tbuckley/cabot-search huggingface dataset:
Risk of Operative Site Bleeding With Parenteral Ketorolac-Reply
Authors: B. L. Strom, J. A. Berlin, J. L. Kinman, S. Hennessy, H. Feldman, S. Kimmel, J. L. Carson
Journal: JAMA (1996)

<h3>In Reply.</h3> —We are glad Dr Gumprecht appreciates the need for postmarketing surveillance studies, and we appreciate the opportunity to respond to his concerns. Unfortunately, we may not have communicated as clearly as we could have, leading to some misinterpretations. First, our study did not show a low risk of operative site bleeding associated with this drug, but in fact a high risk (39.6%; Table 1). However, this risk was not significantly higher than that in a roughly comparable control group (38.6%); even after adjusting for possible confounding, the relative risk was not elevated. A higher risk was observed as the dose of ketorolac increased (<i>P</i>&lt;.001) and in the elderly (<i>P</i>&lt;.02). In contrast, the risk of clinically serious operative site bleeding was much lower (1.55% vs 1.8%, respectively). Second, the study<sup>1</sup>to which Gumprecht refers was not a double-blind trial—it was a retrospective cohort study like ours and less
Effect of gamma aminobutyric acid on the carbon dioxide rebreathing response of normal subjects: a study using vigabatrin.
Authors: A G Fennerty, E M Rimmer, J Boulton, A Richens
Journal: Thorax (1990)

Animal studies suggest that y amino- butyric acid (GABA) may be an impor- tant neurotransmitter in the control of respiration.Vigabatrin, a new drug for the treatment of epilepsy, is thought to exert its effect by increasing GABA con- centrations in the brain.To assess the effect of increased GABA concentrations in the brain on human respiration we measured the ventilatory response to carbon dioxide in seven normal subjects after they had taken vigabatrin or placebo for three days in a double blind crossover study.There was no change in either the slope or the intercept of the curve of the ventilatory response to carbon dioxide after vigabatrin by comparison with placebo.This study suggests that GABA does not have an important role in the control of respira- tion in normal individuals.
Methods of assessing medical treatments
Authors: A Fontaine, P Durieux
Journal: BMJ (1994)

skills will be applied in an increasingly sophisticated way to solve everyday clinical problems.The skills learnt will include critical appraisal, self directed leaming, and group working besides the theory and applications of epidemiology and biostatistics.As our medical school revises the later years of the undergraduate curriculum we look to our clinical colleagues to put the principles of evidence based medicine into practice so that we train a new generation of doctors who will be practising more of the science, as well as the art, of medicine and who will contribute to the knowledge based health service that Smith envisages.
Child psychiatric disorder and relative age in school year: Holding back may cause more harm
Authors: R. M Greenwell
Journal: BMJ (2003)

Synaptotagmins (Syts) are a group of type I membrane proteins that regulate vesicle docking and fusion in processes such as exocytosis and phagocytosis. All Syts possess a single transmembrane domain, and two conserved tandem Ca<sup>2+</sup>-binding C2 domains. However, Syts IV and XI possess a conserved serine in their C2A domain that precludes these Syts from binding Ca<sup>2+</sup> and phospholipids, and from mediating vesicle fusion. Given the importance of vesicular trafficking in macrophages, we investigated the role of Syt XI in cytokine secretion and phagocytosis. We demonstrated that Syt XI is expressed in murine macrophages, localized in recycling endosomes, lysosomes, and recruited to phagosomes. Syt XI had a direct effect on phagocytosis and on the secretion of TNF and IL-6. Whereas small interfering RNA–mediated knockdown of Syt XI potentiated secretion of these cytokines and particle uptake, overexpression of an Syt XI construct suppressed these processes. In addition, Syt XI knockdown led to decreased recruitment of gp91<i><sup>phox</sup></i> and lysosomal-associated membrane protein–1 to phagosomes, suggesting attenuated microbicidal activity. Remarkably, knockdown of Syt XI ensued in enhanced bacterial survival. Our data reveal a novel role for Syt XI as a regulator of cytokine secretion, particle uptake, and macrophage microbicidal activity.
Bullets, Lead Poisoning, and Thyrotoxicosis
Authors: CHARLES R. CAGIN
Journal: Annals of Internal Medicine (1978)

A patient with a retained bullet developed lead poisoning in association with thyrotoxicosis. The clinical and laboratory data suggest that lead was mobilized from an increased mobile bone pool during the hypermetabolic period with resultant poisoning. The findings give factual support to earlier concepts that lead poisoning may occur during periods of metabolic change in an individual with an increased body lead burden.
Prostate Biopsies Guided by Three-Dimensional Real-Time (4-D) Transrectal Ultrasonography on a Phantom: Comparative Study versus Two-Dimensional Transrectal Ultrasound-Guided Biopsies
Authors: Jean-Alexandre Long, Vincent Daanen, Alexandre Moreau-Gaudry, Jocelyne Troccaz, Jean-Jacques Rambeaud, Jean-Luc Descotes
Journal: European Urology (2006)
Clinical Characterization of Node-Negative Lung Adenocarcinoma: Results of a Prospective Investigation
Authors: Ichiro Yoshino, Yukito Ichinose, Akira Nagashima, Sadanori Takeo, Akira Motohiro, Tokujiro Yano, Hideki Yokoyama, Hitoshi Ueda, Kenji Sugio, Teruyoshi Ishida, Kosei Yasumoto, Yoshihiko Maehara
Journal: Journal of Thoracic Oncology (2006)
Glycoprotein IIb/IIIa inhibitors after full dose thrombolysis in rescue angioplasty for acute myocardial infarction: To give or not give?
Authors: Luis Gruberq, Mahmoud A. Suleiman, Michael Kapellovich, Haimm Hammerman, Ehud Grenadier, Monther Boulus, Walter Markiewicz, Rafael Beyar
Journal: Journal of the American College of Cardiology (2003)
Ex Vivo Assessment of Vascular Response to Coronary Stents by Optical Frequency Domain Imaging
Authors: Masataka Nakano, Marc Vorpahl, Fumiyuki Otsuka, Masanori Taniwaki, Saami K. Yazdani, Aloke V. Finn, Elena R. Ladich, Frank D. Kolodgie, Renu Virmani
Journal: JACC. Cardiovascular imaging (2012)
Two young girls with pyogenic sacroiliitis
Authors: S W Kadir
Journal: Annals of the Rheumatic Diseases (2004)

Pyogenic sacroiliitis is a rare condition with often vague symptoms mimicking common conditions such as protruded disk, muscular strain, or visceral pain. Therefore the diagnosis is often missed or delayed. In 1986, Cohn and Schoetz reviewed patients with pyogenic sacroiliitis.1 In 12.6% of these cases sacroiliitis mimicked the acute abdomen. In 40–60% fever and a raised erythrocyte sedimentation rate were present. Blood cultures were positive in 60%. Magnetic resonance imaging and computer tomography can be helpful, but especially when blood cultures are negative, joint aspiration can be crucial for establishing the diagnosis. We present two cases of infectious sacroiliitis.

### Patient 1

A 19 year old woman was admitted to hospital with a 4 day history of pain in the right hip and buttock, and fever. Walking was difficult and transfers were impossible to …
Ventricular Pacing Lead Location Alters Systemic Hemodynamics and Left Ventricular Function in Patients With and Without Reduced Ejection Fraction
Authors: Randy Lieberman, Luigi Padeletti, Jan Schreuder, Kenneth Jackson, Antonio Michelucci, Andrea Colella, William Eastman, Sergio Valsecchi, Douglas A. Hettrick
Journal: Journal of the American College of Cardiology (2006)
Heart Weight of Jamaicans
Authors: J. A. HAYES, H. G. LOVELL
Journal: Circulation (1966)

The heart weight and the weights of the component parts have been measured in a group of 126 Jamaicans of African origin on whom autopsy was performed at the Pathology Department of the University of the West Indies. This series comprised 58 normal [see table in the PDF file] cases, 46 cases of hypertension, and 22 cases of chronic lung disease. The mean heart weight for normal males was 294.5 g and for females 258.5 g. These figures are similar to those reported from Uganda but less than those from Britain and North America. The differences in heart weight are probably correlated with difference in body size. Total heart weight in the hypertensives was greater than in normals because of left ventricular hypertrophy. In chronic lung disease total heart weight was greater than that of normals due to enlargement of the right ventricle and of the combined atria. Right ventricular weight was also increased in cases of hypertension.
G20 pathologist acted irresponsibly in earlier cases
Authors: H. Mooney
Journal: BMJ (2010)

The Home Office pathologist who suggested that the newspaper seller Ian Tomlinson had died of a heart attack during the G20 protest in London in April 2009 behaved irresponsibly in a series of other autopsies, a General Medical Council disciplinary panel has ruled.

The GMC found Freddy Patel had been “irresponsible” in earlier unrelated examinations; he could now be suspended or struck off the medical register at a later hearing.

Dr Patel’s findings on the death of Mr Tomlinson differed from those of two colleagues, and led to no charges being brought over the death …
Apparent Failure in Endocarditis Prophylaxis
Authors: Martin S. Greenberg
Journal: JAMA (1984)

<h3>To the Editor.—</h3> I read the article by Durack et al,<sup>1</sup>"Apparent Failure of Endocarditis Prophylaxis," with interest, since objective data regarding the value of the antibiotic regimen recommended by the American Heart Association and the American Dental Association are not currently available. The national registry on rheumatic fever and bacterial endocarditis described in the article is a worthwhile effort to obtain vital information. However, it appears that important data are being lost since a report is only obtained from the physician treating the patient for bacterial endocarditis. For example, the authors describe the antibiotic used and duration of prophylaxis but not the preoperative loading dose that is considered the most important aspect of the prophylactic regimen. This information would be best obtained from the dentist or surgeon who prescribed the antibiotic prior to the procedure. I suggest that follow-up questionnaires be sent these clinicians for every reported case
indel-Seq-Gen: A New Protein Family Simulator Incorporating Domains, Motifs, and Indels
Authors: C. L. Strope, S. D. Scott, E. N. Moriyama
Journal: Molecular Biology and Evolution (2006)

Reconstructing the evolutionary history of protein sequences will provide a better understanding of divergence mechanisms of protein superfamilies and their functions. Long-term protein evolution often includes dynamic changes such as insertion, deletion, and domain shuffling. Such dynamic changes make reconstructing protein sequence evolution difficult and affect the accuracy of molecular evolutionary methods, such as multiple alignments and phylogenetic methods. Unfortunately, currently available simulation methods are not sufficiently flexible and do not allow biologically realistic dynamic protein sequence evolution. We introduce a new method, indel-Seq-Gen (iSG), that can simulate realistic evolutionary processes of protein sequences with insertions and deletions (indels). Unlike other simulation methods, iSG allows the user to simulate multiple subsequences according to different evolutionary parameters, which is necessary for generating realistic protein families with multiple domains. iSG tracks all evolutionary events including indels and outputs the "true" multiple alignment of the simulated sequences. iSG can also generate a larger sequence space by allowing the use of multiple related root sequences. With all these functions, iSG can be used to test the accuracy of, for example, multiple alignment methods, phylogenetic methods, evolutionary hypotheses, ancestral protein reconstruction methods, and protein family classification methods. We empirically evaluated the performance of iSG against currently available methods by simulating the evolution of the G protein–coupled receptor and lipocalin protein families. We examined their true multiple alignments, reconstruction of the transmembrane regions and beta-strands, and the results of similarity search against a protein database using the simulated sequences. We also presented an example of using iSG for examining how phylogenetic reconstruction is affected by high indel rates.
Unchanged Insulin Absorption After 4 Days' Use of Subcutaneous Indwelling Catheters for Insulin Injections
Authors: S Ragnar Hanas, Sten Carlsson, Anders Frid, Johnny Ludvigsson
Journal: Diabetes Care (1997)

Since 1985, we have used indwelling catheters (Insuflon, Maersk Medical, Lynge, Denmark; Chronimed, Minnetonka, MN) to lessen pain when injecting insulin. However, some patients experience a rise in blood glucose after using indwelling catheters for a few days. We therefore studied the absorption of 125I-labeled insulin when using indwelling catheters.Five men and five women participated (age 18-25 years, C-peptide negative, HbA1c 9.0 +/- 1.0% [mean +/- SD, DCA-2000 method], diabetes duration 5-21 [median 9.5] years). After thyroid blockage with potassium iodide, we injected 5IU of 125I-labeled short-acting insulin subcutaneously in the abdomen ("ordinary injection") and 5 IU on the contralateral side through an indwelling catheter ("catheter injection"). The injection/insertion area was free of lipohyper- and lipohypotrophies. Disappearance rate was measured for 180 min with a gamma camera. The patients injected all premeal injections of short-acting insulin through the same indwelling catheter in the following 4 days. The investigation procedure was repeated day 3 and 5.We found no statistically or clinically (95% CI) significant difference in residual activity of 125I-insulin after 60 min or in time for 50% of the injected depot to disappear (T-50%) among catheter injections on day 1, 3, and 5; ordinary injections on days 1, 3, and 5; or catheter and ordinary injections on days 1, 3, and 5, respectively. HbA1c correlated both to T-50% (r = 0.73, P = 0.016) and residual activity of 125I-insulin after 60 min (r = 0.69, P = 0.028), indicating that patients with a slower absorption will have a less ideal metabolic control when using premeal bolus injections.We conclude that using indwelling subcutaneous catheters for insulin injections for up to 4 days does not affect the absorption of short-acting insulin.
THE THERAPEUTIC VALUE OF EGG YOLK IN RICKETS
Authors: ALFRED F. HESS
Journal: JAMA (1923)

Yolk of egg has frequently been employed in the diets of infants, and is brought forward here not as a new food, but rather as a therapeutic agent. Generally it has been resorted to with the purpose of increasing the percentage of fat or the caloric value of the food. Recently, De Sanctis1has suggested this addition in order to augment the content of water soluble vitamin, which, according to the investigations of Osborne and Mendel,2is present in yolk in moderate degree. Some years ago,egg yolk was employed on an extensive scale in the Home for Hebrew Infants, and was found a most valuable supplement to milk formulas. Not only did the infants gain steadily in weight, but their general appearance was healthy, the tonicity of their muscles was exceptionally good, and their stools seemed normal. Indeed, the gains in weight were better than those obtained with
A VOICE FROM THE PAST.
Authors: William Bainbridge
Journal: JAMA (1896)

In connection with the attempt being made by the medical officers of the Navy to obtain the same rank, pay and emoluments as the medical officers of the Army, in which they have received the unanimous support of theAmerican Medical Association, theAmerican Academy of Medicine, and theAssociation of Military Surgeons of the United States, the subjoined letter to a former Secretary of the Navy, written eighty years ago and signed by the senior line officers of the Navy, the heroes of the war of 1812, will be of interest to the members of the medical profession. The hearty indorsement of the claims of the medical officers of the Navy to consideration, the generous appreciation of the value of their services, the unqualified recognition of their military status, and the declaration "that justice requires they should, at all events, receive a compensation and rank equal to what has
The effect of changing interpulse intervals on the negative chronotropic response to repetitive bursts of vagal stimuli in the dog.
Authors: M N Levy, S Wexberg, C Eckel, H Zieske
Journal: Circulation Research (1978)

The chronotropic responses to repetitive bursts of vagal stimulation were determined in open-chest, anesthetized dogs. Either 5 or 10 electrical pulses were included in each stimulus burst, and the interpulse interval (deltat) was varied over the range of 5 to 150 msec. As the frequency of the stimulus bursts was progressively changed, the sinoatrial (SA) nodal pacemaker cells became synchronized with the repetitive bursts of stimuli over a certain range of burst frequencies. The magnitude of this frequency range varied with deltat. For 5 and 10 pulses/burst, the values of deltat that produced the greatest magnitude of this frequency range were 30.2 and 24.3 msec, respectively. Also, over the range of values of deltat from 5 to 50 msec, the magnitude of the negative chronotropic effect of the vagal stimulus burst varied directly with deltat. It is likely that, as the interpulse interval is increased within the range of values, either more acetylcholine is released from the vagal nerve endings per pulse or there is less saturation of the receptors on the pacemaker cell membranes during each burst.
When financial incentives do more good than harm: a checklist
Authors: P. P. Glasziou, H. Buchan, C. Del Mar, J. Doust, M. Harris, R. Knight, A. Scott, I. A. Scott, A. Stockwell
Journal: BMJ (2012)

Financial incentives can sometimes improve the quality of clinical practice, but they may also be an expensive distraction. <b>Paul Glasziou and colleagues </b>have devised a checklist to help prevent their premature or inappropriate implementation
Diagnosis of Pneumocystis carinii Pneumonia by Cytologic Examination of Bronchial Washings
Authors: Edwarda Rorat
Journal: JAMA (1985)

During the last three years, bronchial washings from patients in whom<i>Pneumocystis carinii</i>pneumonia was clinically suspected were cytologically examined. These were predominantly cases of suspected or confirmed acquired immunodeficiency syndrome. To determine the effectiveness of cytologic diagnosis by means of a bronchial wash, retrospective analysis of bronchial washings with available simultaneous transbronchial biopsy specimens was carried out in 181 cases. Comparison of the results of both methods revealed an excellent correlation.<i>Pneumocystis carinii</i>was identified in 108 specimens of washes and in 103 specimens of biopsies. Our data indicate that<i>P carinii</i>can be consistently and reliably identified in the smears from bronchial washes, without lung tissue biopsy, thus sparing the patient the latter procedure if contraindications exist. (<i>JAMA</i>1985;254:1950-1951)
PD07-04: Lapatinib vs Trastuzumab in Combination with Standard EC-D Chemotherapy in the Neaodjuvant Treatment of HER2+ Patients. Results from the GEICAM 2006–14 Phase II Randomized Trial.
Authors: E Alba, J Albanell, J de la Haba, A Barnadas, L Calvo, P Sánchez, M Ramos, F Rojo, O Burgués, I Porras, A Tibau, E Carrasco, MC Cámara, A Lluch
Journal: Cancer Research (2011)

Abstract Background: The addition of trastuzumab (T) to neoadjuvant chemotherapy increases pCR rate in patients with HER2 + breast cancer. Lapatinib (L) in combination with chemotherapy is also an active drug in breast cancer patients. This study investigates the efficacy of trastuzumab or lapatinib added to chemotherapy in the neoadjuvant setting. Methods: Patients (Pt) with tumors greater than 2 cm (or less with positive axilla) and HER2+ (Herceptest 3+ or 2+ with FISH+) that have not received any prior treatment for breast cancer were recruited. Pts were randomized to receive epirubicin 90 mg/m2 plus cyclophosphamide 600 mg/m2 × 4 cycles (cy) followed by docetaxel 100 mg/m2 (with growth colony stimulating factor support) plus either T 8 mg/kg loading dose and then 6 mg/Kg intravenous (EC-DT) or L 1250 mg orally (EC-DL). Patients were stratified according to tumor size (T1-2 vs T3-4), and estrogen receptor status (positive vs negative). The primary end-point was pathological complete response (pCR) in the breast measured by Miller and Payne criteria. Secondary end-points were clinical response (by imaging test), toxicity and correlation between pCR and tumor biomarkers. Results: From February-09 to October-10, 102 pts were randomized (50 EC-DT, 52 EC-DL). Pts characteristics were well balanced between arms. Median age was 48 years (30-79), 56% of pts were premenopausal, 7% grade I, 45% grade III. 14/59/12/15% were T1/T2/T3/T4 and 69% N+. 58% were estrogen receptor positive and 44% progesterone receptor positive. Three patients were FISH negative after central assessment and were not considered evaluable for efficacy. pCR rate in the breast was 52% (95% CI: 38–66) for EC-DT and 25% (95% CI: 13.5−37.5) for EC-DL (p-value=0.0065). pCR—pN0 was 48% (95% CI: 34–62) for EC-DT and 24% (95% CI: 12 - 35) for EC-DL (p-value=0.01). Clinical response was 77% with EC-DT and 65% with EC-DL (p-value=0.176). Grade III-IV toxicity was similar between arms except for diarrhea that was more frequent in EC-DL 14% than in EC-DT 2% (p-value=0.03); more patients discontinue treatment due to toxicity with EC-DL (1 vs 6; p-value=0.055). Conclusions: Our study shows that EC-DT was more efficacious and less toxic than EC-DL in the neoadjuvant treatment of HER2+ pts. Biomarker profiling in the tumors, including activation levels of tyrosine-kinase receptors, signaling pathways and surrogate markers (proliferation and apoptosis) is ongoing; their correlation with pCR will be presented at the meeting. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr PD07-04.
Intralesional injection of enoxaparin in benign symmetrical lipomatosis: an alternative to surgery?
Authors: M. Fischer, J. Wohlrab, K-M. Taube, W.C. Marsch
Journal: British Journal of Dermatology (2001)

Journal Article Intralesional injection of enoxaparin in benign symmetrical lipomatosis: an alternative to surgery? Get access M. Fischer, M. Fischer Department of Dermatology and Venereology, Martin‐Luther‐University Halle‐Wittenberg, Ernst‐Kromayer‐Straße 5–8, D‐06097 Halle (Saale), Germany Correspondence: E‐mail: matthias.fischer@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar J. Wohlrab, J. Wohlrab Department of Dermatology and Venereology, Martin‐Luther‐University Halle‐Wittenberg, Ernst‐Kromayer‐Straße 5–8, D‐06097 Halle (Saale), Germany Correspondence: E‐mail: matthias.fischer@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar K‐M. Taube, K‐M. Taube Department of Dermatology and Venereology, Martin‐Luther‐University Halle‐Wittenberg, Ernst‐Kromayer‐Straße 5–8, D‐06097 Halle (Saale), Germany Correspondence: E‐mail: matthias.fischer@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar W.C. Marsch W.C. Marsch Department of Dermatology and Venereology, Martin‐Luther‐University Halle‐Wittenberg, Ernst‐Kromayer‐Straße 5–8, D‐06097 Halle (Saale), Germany Correspondence: E‐mail: matthias.fischer@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 3, 1 March 2001, Pages 629–630, https://doi.org/10.1046/j.1365-2133.2001.04102.x Published: 01 March 2001
Toxicity of tretinoin in acute promyelocytic leukaemia
Authors: J.Forjaz de Lacerda, Klaus Schmitt, Rudolf Schwarz, Gerald Tulzer, Otto Krieger, Andreas Zoubek, Helmut Gadner, Masaaki Yokokura, Kiyohiko Hatake, Norio Komatsu, Hitoshi Kajitani, Yasusada Miura
Journal: The Lancet (1994)