tbuckley/cabot-search huggingface dataset:
Multiple Tracheobronchial Melanomas With Ten-Year Survival
Authors: Louis M. Rosenberg
Journal: JAMA (1965)

TRACHEOBRONCHIAL melanoma is extremely rare. Reviewing the literature in 1963, Salm<sup>1</sup>encountered four cases and added one of his own, but he pointed out that three of the previous cases lacked sufficient documentation. The only case that he accepted as being adequately documented was that of Allen and Spitz,<sup>2</sup>which presented with a bronchial lesion six years after the removal of a melanoma from the palate. <h3>Report of a Case</h3> In May 1951 this 46-year-old woman had a melanoma excised from her left cheek. She was then asymptomatic until April 1954, when she was admitted to the Jewish Hospital because of hemoptysis. Physical examination, routine laboratory work, and chest x-rays showed no abnormalities. At bronchoscopy, a fungating mass partially obstructing both main bronchi was seen. It was partially removed and the base was fulgurated. Microscopic diagnosis of the material was malignant melanoma. Bronchoscopy was repeated a few days
Tissue Plasminogen Activator
Authors: John A. Oates, Alastair J.J. Wood, Joseph Loscalzo, Eugene Braunwald
Journal: New England Journal of Medicine (1988)

TISSUE plasminogen activator (t-PA) is a naturally occurring protein that catalyzes the conversion of the inactive proenzyme plasminogen into the active serine protease plasmin. It is one of two major endogenous mammalian enzymes with this property and is found in blood and tissue from various organs. Although it exerts a similar enzymatic action, it is structurally different from the other major endogenous enzyme, urokinase. t-PA was first identified as a product of melanoma cells in 1980,1 and Rijken and Collen2 first purified the enzyme from melanoma cells in culture one year later. The isolation of the complementary DNA coding for . . .
A state run healthcare system is still relevant today, debate decides
Authors: Tessa Richards
Journal: BMJ (2008)

A debate to consider whether the NHS still meets the needs of the population 60 years after it was established decided that it still does. In fact the proportion of the audience who thought it was still a suitable system today rose by seven percentage points during the course of the debate.

The debate was organised by Capse Health Knowledge Systems, a private company that measures the performance of UK hospitals, and was held at the Tate Britain art gallery, in front of an invited audience of around 160 hospital managers, academics, healthcare economists, clinicians, and journalists.

The wording of the motion was “This house believes that a state run healthcare system can no longer meet the needs of the population and that greater competition will improve the quality of care and secure its future.”

The case for the motion was put by Nick Bosanquet, professor …
Occult Pulmonary Hemorrhage
Authors: ABRAHAM ARONOW
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 April 1976Occult Pulmonary HemorrhageABRAHAM ARONOW, M.D., GARY G. KARDOS, M.D.ABRAHAM ARONOW, M.D.Search for more papers by this author, GARY G. KARDOS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-4-491 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Occult pulmonary hemorrhage in anticoagulated patients has been reported recently (1). Case one of that report was that of a lady with bilateral extensive pulmonary infiltrates without hemoptysis while on hydralazine and coumadin. This lady had a positive test for antinuclear antibody. She recovered uneventfully after withdrawal of medication, and she has had no sequelae.Another recent case had similar features.An 18-year-old achondroplastic white boy known to have chronic glomerulonephritis for 2 years presented with florid renal failure, fluid overload, cardiomegaly, and severe hypertension. After having been started on α-methyldopa, hydralazine, and propranolol, he began a...References1. FINLEYARONOWCOSENTINO TAA: Occult pulmonary hemorrhage in anticoagulated patients. Am Rev Resp Dis 112:23-29, 1975 MedlineGoogle Scholar2. CONDEMIMOORE-JONESVAUGHAN JDJ: Antinuclear antibodies following hydralazine toxicity. N Engl J Med 279:486-491, 1967 CrossrefGoogle Scholar3. GOULDSORIANO DR: Acute alveolar hemorrhage in lupus erythematosus. Ann Intern Med 83:836-837, 1975 LinkGoogle Scholar4. DONALDEDWARDSMCEVOY KRJ: Alveolar capillary basement membrance lesions in Goodpasture's syndrome and idiopathic pulmonary hemosiderosis. Am J Med 59:642-649, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine R. K. Davies Medical Center Franklin Hospital San Francisco, California 94114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMoxalactam Disodium-Induced Pulmonary Hemorrhage 1 April 1976Volume 84, Issue 4Page: 491-492KeywordsAntinuclear antibodiesGlomerulonephritisHemorrhageHypertensionRenal failure Issue Published: 1 April 1976 PDF DownloadLoading ...
Editorial: Pulmonary embolism
Authors: H. H. Hussey
Journal: JAMA (1973)

Dalen and Dexter<sup>1</sup>rightly emphasized the importance and the difficulty of diagnosing pulmonary embolism. The importance rests with the facts that the condition is frequent in hospitalized patients and that it is potentially lethal, constituting one of the three most common causes of death at the authors' hospital. The diagnosis is difficult because pulmonary embolism is a great masquerader. Thus, Dalen and Dexter named four different clinical syndromes: (1) pulmonary infarction, (2) acute cor pulmonale, (3) acute, unexplained dyspnea, and (4) aggravation of preexisting left ventricular failure. The diagnosis is assisted, of course, when a source for emboli is identified, such as evidence of phlebothrombosis in the deep veins of the calf (calf tenderness, positive Homans sign, slight cyanosis of the leg and prominence of superficial veins when the legs are dependent, an abnormal phlebogram). In the table accompanying their essay, the authors listed the important emergency diagnostic tests
Management of Type IV Hyperlipoproteinemia
Authors: L K Smith, R V Luepker, S S Rothchild, A Gillis, L Kochman, J R Warbasse
Journal: Annals of Internal Medicine (1976)

A lipid intervention clinic screened 4000 employees (89% participation) and identified 150 type IV subjects (top 5 percentile triglyceride values, 100% initial participation, 6% drop out). The 150 healthy type IV subjects, ages 20 to 49, were randomly divided into treatment subgroups: A, treatment by clinic nutritionist and physician with the National Heart and Lung Institute's type IV diet for 6 weeks, then diet plus Clofibrate for 18 weeks; B, same treatment by private physician; C, no intervention for 24 weeks, subjects advised of abnormality. The group A mean fasting serum triglyceride of 407 mg/dl declined 50% at 6 weeks, 61% at 12 weeks, and was unchanged at 24 weeks (P < 0.0005 at 6, 12, 24 weeks). Group B triglyceride decreased 42%, 50%, 41% (P < 0.0005 at 6, 12, 24 weeks). Group C triglyceride declined 20%, 1st to 24th week. Body weight decreased 8% (A) and 4% (B) at 6 weeks (P < 0.0005) and was unchanged at 24 weeks. The maximum cholesterol decrease (A) was 11% (P < 0.0005). Type IV hyperlipoproteinemia can readily be identified in a working population; treatment by clinic or private physician will markedly lower fasting serum triglyceride values in apparently healthy type IV subjects for at least 24 weeks.
A double-blind crossover trial of methandienone (Dianabol, CIBA) in moderate dosage on highly trained experienced athletes.
Authors: D. L. Freed, A. J. Banks
Journal: British Journal of Sports Medicine (1975)

Depolarization-induced suppression of inhibition (DSI) is a retrograde form of synaptic inhibition involving the Ca<sup>2+</sup>-dependent release of cannabinoids from the postsynaptic cell. DSI exerts multiple effects on presynaptic neurons: here, we establish the breakdown of DSI in its individual components at the synapses between basket and stellate cells and Purkinje cells. In the presence of tetrodotoxin, the change in IPSC frequency entirely accounted for the decrease of transmission during DSI; in contrast, without tetrodotoxin, the reductions of frequency and average amplitude gave equal contributions. In paired recordings, transmission displayed an irreversible rundown unless interneurons were recorded from with the perforated patch method. Under these conditions, a DSI of 68.8% was measured; the failure rate and the paired pulse ratio (at 20 msec intervals) increased from 1.2 to 20.2 and 95.6 to 132.6%, respectively, and the variance to mean ratio augmented 2.17-fold. Presynaptic dialysis with Cs<sup>+</sup> led to a major potentiation of synaptic strength and to a marked reduction of DSI with respect to control potassium conditions; DSI recovered only partially when decreasing the extracellular Ca<sup>2+</sup> concentration to match the control IPSC amplitudes. These results, combined with those of Kreitzer et al. (2002), indicate that three distinct presynaptic processes contribute to DSI: reductions of miniature frequency (13.4% of total DSI), of presynaptic action potential frequency (23.2%), and of the probability that presynaptic depolarizations elicit transmitter release (63.4%). The latter component involves a modulation of K<sup>+</sup> channels and trial-to-trial modifications of the presynaptic signal.
Fantasy in Münchausen's Syndrome
Authors: ROBERT A. FAGUET
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 December 1980Fantasy in Münchausen's SyndromeROBERT A. FAGUET, M.D.ROBERT A. FAGUET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-6-935_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their paper "Probing the Dynamics of Münchausen's Syndrome: Detailed Analysis of a Case," Justus and associates (1) review a number of motivations for the remarkable behavior of patients with Münchausen's syndrome. One of their explanations, that patients are searching for maternal care, is supported by the connection between Münchausen's syndrome (factitious illness, peregrination, Pseudologia fantastica) and the fantasy connected with the rare sexual disorder of necrophilia. This fantasy reflects a specific form of the wish to enter the mother's body and explore its interior and its contents, a wish rooted in the primitive desire to effect...References1. JUSTUSKREUTZIGERKITCHENS PSC. Probing the dynamics of Münchausen's syndrome: detailed analysis of a case. Ann Intern Med. 1980;93(Part 1):120-7. LinkGoogle Scholar2. CALEFWEINSHEL VE. On certain neurotic equivalents of necrophilia. Int J Psychoanal. 1972;53:67-75. MedlineGoogle Scholar3. FAGUET R. Munchausen syndrome and necrophilia. Suicide Life Threat Behav. 1980; In press. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 1800 Fairburn Avenue, Suite 200; Los Angeles, CA 90025 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPsychiatric Munchausen's syndromeLes maladies factices et le syndrome de Münchausen 1 December 1980Volume 93, Issue 6Page: 935-935KeywordsBehaviorMotivation Issue Published: 1 December 1980 PDF DownloadLoading ...
Eosinophilia in routine blood samples and the subsequent risk of hematological malignancies and death
Authors: Christen Lykkegaard Andersen, Volkert Dirk Siersma, Hans Carl Hasselbalch, Hanne Lindegaard, Hanne Vestergaard, Peter Felding, Niels de Fine Olivarius, Ole Weis Bjerrum
Journal: American Journal of Hematology (2013)

Eosinophilia may represent an early paraclinical sign of hematological malignant disease, but no reports exist on its predictive value for hematological malignancies. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count (DIFF) encompassing the eosinophil count during 2000-2007. From these, one DIFF was randomly chosen and categorized according to no (<0.5 × 10(9) /L), mild (≥ 0.5-1.0 × 10(9) /L) or severe (≥ 1.0 × 10(9) /L) eosinophilia. From the Danish Cancer Registry and the Danish Civil Registration System, we ascertained hematological malignancies and death within 3 years following the DIFF. Using multivariable logistic regression odds ratios (ORs) were calculated and adjusted for previous eosinophilia in a DIFF, sex, age, year, month, C-reactive protein, previous cancer, and comorbidity. ORs for developing Hodgkin's lymphoma (HL) was significantly increased in individuals exhibiting severe eosinophilia, OR = 9.09 (C.I. 2.77-29.84), P = 0.0003. The association with classical myeloproliferative neoplasms (cMPNs) showed an increasing risk with OR = 1.65 (1.04-2.61) P = 0.0322 and OR = 3.87 (1.67-8.96) P = 0.0016 for mild and severe eosinophilia. Eosinophilia was in a similar fashion associated with chronic lymphatic leukemia (CLL), OR = 2.57 (1.50-4.43), P = 0.0006 and OR = 5.00 (1.57-15.94), P = 0.0065, and all-cause death, OR of 1.16 (1.09-1.24), P < 0.0001 and 1.60 (1.35-1.91), P < 0.0001. We confirm associations between eosinophilia and HL and cMPNs, and in addition for the first time demonstrate a dose-dependent association between eosinophilia and CLL as well as death. Unexplained eosinophilia should prompt clinicians to consider conditions where early diagnosis may improve prognosis.
Evaluation of a Muscle Relaxant: Dantrolene Sodium (Dantrium)
Authors: Michael H. M. Dykes
Journal: JAMA (1975)

Dantrolene sodium (Dantrium) is a skeletal muscle relaxant, unique in that it acts on the muscle itself. It should be considered for use in patients with skeletal muscle spasticity who are in a stable neurological state. After careful adjustment of the dose, a substantial number of such patients will experience one or more of the following benefits: (1) a reduction in pain, (2) an increased ability to make use of residual motor function, (3) a reduction in the level of nursing care required, (4) an increased ability to utilize devices, and (5) an increased ability to participate in rehabilitation. The drug should not be used when reduced spasticity will decrease functional ability. The adverse effects generally are transient; some are the result of central nervous system depression. (<i>JAMA</i>231:862-864, 1975)
Tc-99m DTPA Cisternography Shows Disappearance of Cerebrospinal Fluid Leakage After Standing a Short Time
Authors: Del Mastro Carolina, Cicone Francesco, D'Andrea Giancarlo, Scopinaro Francesco
Journal: Clinical Nuclear Medicine (2008)

Radionuclide cisternography can demonstrate cerebrospinal fluid (CSF) leakage in some cases of the spontaneous intracranial hypotension syndrome. If symptoms do not disappear spontaneously after rest, epidural blood patching usually follows with good results. Cisternography often provides the only indirect signs of leakage with early bladder and/or slight cranial activity. We present a case of a 56-year-old man with a posterior thoracic CSF leak demonstrated by Tc-99m diethylenetriaminepentaacetic acid (DTPA) cisternography. The extraspinal radioactivity was visible after the patient was supine for several hours and disappeared after a short time of standing, providing direct evidence of a CSF leak.
Role of quinine in the high mortality of intramuscular injection tetanus
Authors: L.M Yen, L.M Dao, L.H Son, T.T Hien, N.P.J Day, D.J Waller, D.B Bethell, N.J White, N.P.J Day, D.J Waller, D.B Bethell, Nj White
Journal: The Lancet (1994)
Abstract 3513: The anti-tumor effect of activated natural killer cells in xenograft mouse models with epithelial ovarian cancer
Authors: Mo Jin Young, Lee Kyoung-jin, Whang Yoo-Kyeong, Lee Shin-Wha, Kim Yong-Man, Kim Dae-Yeon, Kim Jong-Hyeok, Nam Joo-Hyun, Kim Young-Tak
Journal: Cancer Research (2012)

Abstract Objectives: Ovarian cancer is the most common cause of death from gynecologic cancer in women. Because of the lack of effective screening and warning sign, 60-70% of patients were diagnosed at advanced stage. At present the treatment of advanced ovarian cancer is cytoreductive surgery followed by chemotherapy, and the overall response rate is 70-80%. But 50-75% of responders will relapse within about 18 -24 months. Therefore, new strategies of treatment, for examples, immunotherapy or targeted therapy, are necessary. This study is to evaluate the anti-tumor effect of activated natural killer (NK) cells in xenograft mouse model with epithelial ovarian cancer(EOC). Methods: We have made the OVCAR3-Luc stable cell line by transient transfection of pGL3-Luciferase (G418) gene. The xenograft mouse model of EOC was constructed by the intra-peritoneal injection of OVCAR3-Luc ovarian cancer cell line to the NOD/scid mice. After we confirm the tumor formation with IVIS spectrum, activated NK cells were injected with intra-peritoneal route. There was no treatment to the negative control and paclitaxel (10mg/kg) was used to the positive control. The tumor growth was evaluated by serial IVIS spectrum and biopsy at 8 weeks after any treatment. Results: Activated NK cells were injected at concentration 1 × 107 cells per mouse with intra-peritoneal route. This procedure was repeated 5 times. The NK cells significantly inhibited the tumor growth of OVCAR3-Luc-induced NOD/scid mice, up to the 57.1% comparing the negative control. Although paclitaxel decrease 69.3% of the tumor growth, it is not different to that of NK cell treating mice. Furthermore, side effects involving hair loss, abnormal behavior and weight low were not shown in NK cell-injected mouse models. Conclusion: We confirmed that activated NK cells are able to inhibit ovarian tumor growth without side effect in xenograft models. Therefore, this research demonstrates that NK cell-based immunotherapy might be desirable to the patients with ovarian cancer as an adoptive immunotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3513. doi:1538-7445.AM2012-3513
Long-term (1 year) functional and histological results of autologous skeletal muscle cells transplantation in rat
Authors: N ALATTAR, C CARRION, S GHOSTINE, I GARCIN, J VILQUIN, A HAGEGE, P MENASCHE
Journal: Cardiovascular Research (2003)

Several studies have demonstrated the short-term benefits of autologous skeletal muscle cell transplantation on postinfarction left ventricular function. The present experiments were designed to assess the long-term effects of the procedure.Thirteen Wistar rats that had undergone skeletal muscle cell transplantation (n=6) or injection of control culture medium (n=7) in isoforms areas after myocardial infarction created by coronary artery ligation and survived for 1 year were functionally assessed by combining echocardiography and pressure-volume loops. At 1 year after transplantation, both contractile and relaxation indices were significantly improved in the skeletal muscle cell-grafted group compared with controls. One-year echocardiographic measurements of ejection fraction were similar to those recorded 2 months after the procedure. The stability of the functional outcome contrasted with a decrease in the number of histologically detectable skeletal myotubes over time. However, the proportion of the slow and composite (fast and slow) myosin isoforms expressed by skeletal muscle fibers still present after 1 year was greater than that found in animals sacrificed after 2 months.The functional benefits of autologous skeletal muscle cell transplantation are sustained over time and are associated with either selection, preservation or an increased expression of slow myosin heavy chain isoforms. The discrepancy between maintenance of this improvement and the decay in the engrafted myotubes suggests protective mechanisms operative from the early post-transplantation stage and possibly involving modulation of extracellular matrix remodelling or paracrinally induced maturation of putative cardiac resident stem cells.
Prolonged benefit following ultraviolet A phototherapy for solar urticaria
Authors: R.S. DAWE, J. FERGUSON
Journal: British Journal of Dermatology (1997)

Two patients with severe idiopathic solar urticaria, previously resistant to a variety of therapies including plasma exchange, benefited from springtime courses of ultraviolet A (UVA) monotherapy. Sites which are normally exposed to sunlight were treated, in a cabinet fitted with Philips R-UVA lamps (emitting UVA and visible wavelengths, with peak at 350 nm), twice daily for 2-3 weeks. One patient has been treated in this way for 3, and the other for 2, consecutive years. Repeat monochromator phototesting 3 months after their latest courses of UVA showed a persistent reduction in severity of abnormal photosensitivity. Both patients describe a sustained improvement in their condition lasting over 6 months after treatment.
P729 HCV GENOTYPE 1A AND 1B: SIMILARITIES AND DIFFERENCES IN CLINICAL FEATURES, THERAPEUTIC OUTCOME AND PREDICTORS OF RESPONSE
Authors: F. Morisco, V. Di Marco, R. Granata, S. Camera, A. Ippolito, M. Margaglione, G. Fattovich, A. Smedile, E. Clery, C. Ferraiuoli, M. Guarino, L. Donnarumma, M.R. Valvano, M. Milella, M.M. Felder, G.B. Gaeta, P. Gatti, P. Tundo, M. Barone, R. Cozzolongo, M. Angelico, G. Mazzella, T. Santantonio, N. Caporaso, A. Andriulli
Journal: Journal of Hepatology (2014)
The Insanitary Labor Camp
Authors: Eugene R. Kelley
Journal: JAMA (1913)

To the Editor:  —InThe Journal, May 10, 1913, p. 1464, is an editorial on this subject. While I concur for the most part in the deductions drawn, one statement is so obviously based on incomplete information that, in justice to our own and several other Western states, I call attention to it. The sentence is the following: Because these camps are controlled by no laws, and because they are not supervised by any state department, they are a grave menace to the health of the laborers occupying them and the inhabitants of distant as well as adjacent towns.  Reports on industrial camps have been made to the Conference of State and Provincial Boards of Health for each of the past four years. The last report, made by myself and Dr. T. D. Tuttle of Montana, has not yet been published, but is practically ready for distribution. This report contains
Bovine spongiform encephalopathy threatens drugs in European Union
Authors: A. Earl-Slater
Journal: BMJ (1997)

Editor—While the debates about bovine spongiform encephalopathy periodically have a high profile in public health, food safety, and agricultural and political environments, the pharmaceutical environment is now becoming seriously entangled in the web of controversy. On 20 February this year the pharmaceutical council of the European parliament accepted the European Commission's proposed revisions to directive 75/18/EEC.

If the revisions are accepted by the European Union's Council of Ministers it will mean that drugs …