tbuckley/cabot-search huggingface dataset:
Heparin-like activity in uterine fluid.
Authors: M E Foley, B D Griffin, M Zuzel, S R Aparicio, K Bradbury, C C Bird, J K Clayton, D M Jenkins, J S Scott, S M Rajah, G P McNichol
Journal: BMJ (1978)

Uterine fluid was collected from a group of normal patients and a group of patients with menorrhagia. Heparin-like activity was detected in 34 out of 38 samples using an anti-Xa heparin assay. The heparin-like activity in uterine fluid was inhibited by adding the heparin antagonist hexadimethrine bromide to the assay. Concentrations of fibrinogen-fibrin degradation products (FDPs) were measured in five samples of uterine fluid. FDPs in the concentration detected had no effect on the anti-Xa assay. Heparin-like activity was higher in the group with menorrhagia, although the differences were not significant. Heparin-like activity increased throughout the menstrual cycle and decreased during menstruation, suggesting a possible cyclical variation in activity. There was no correlation between mast cell numbers in the endometrium and myometrium and heparin-like activity in uterine fluid and no correlation between the numbers and the stage in the menstrual cycle. In a few patients with intrauterine contraceptive devices (IUCDs) heparin-like activity was increased.
Are Pay-for-Performance Programs a Threat to Medical Professionalism?
Authors: Christopher M. Lowther
Journal: Annals of Internal Medicine (2008)

Letters15 April 2008Are Pay-for-Performance Programs a Threat to Medical Professionalism?Christopher M. Lowther, MD, MED, DPDChristopher M. Lowther, MD, MED, DPDFrom Big Horn Basin Skin Centre, Cody, WY 82414.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-8-200804150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The paper by Snyder and Neubauer (1) about pay-for-performance and medical ethics falls short. Recently, I had 2 patients—a husband and wife who were both overweight and had diabetes—become angry with me when I discussed the need to diet. I held my tongue and did not turn them away.When Germany developed the first antibiotic sulfa drugs in the 1930s, only the United States allowed their use without adequate research. Multiple patients died from dangerous unregulated formulations, and this led to the formation of the U.S. Food and Drug Administration. Don't we have a responsibility to our ...Reference1. Snyder L, Neubauer RL. American College of Physicians Ethics, Professionalism and Human Rights Committee. Pay-for-performance principles that promote patient-centered care: an ethics manifesto. Ann Intern Med. 2007;147:792-4. [PMID: 18056664] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Christopher M. Lowther, MD, MED, DPDAffiliations: From Big Horn Basin Skin Centre, Cody, WY 82414.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPay-for-Performance Principles That Promote Patient-Centered Care: An Ethics Manifesto Lois Snyder and Richard L. Neubauer , for the American College of Physicians Ethics, Professionalism and Human Rights Committee* Are Pay-for-Performance Programs a Threat to Medical Professionalism? Howard Brody Are Pay-for-Performance Programs a Threat to Medical Professionalism? Richard L. Neubauer and Lois Snyder Are Pay-for-Performance Programs a Threat to Medical Professionalism? Paulette Metoyer Metrics 15 April 2008Volume 148, Issue 8Page: 630KeywordsConflicts of interestDietDrugsFallsLegislationMedical ethicsOverweightPatientsTongue ePublished: 15 April 2008 Issue Published: 15 April 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Nutrition and hydration for the terminally ill
Authors: R. L. Fainsinger
Journal: JAMA (1995)

To the Editor.  —The report by Dr McCann and colleagues 1 on the clinical significance of artificial nutrition and fluids in terminally ill patients perpetuates the mistakes of previous reports that have placed the two issues on an equal footing.  The authors correctly refer to articles that have failed to demonstrate a benefit of nutritional support in patients with advanced cancer, but in the same sentence include hydration, which was not studied in those reports.  The controversy over the value of hydration in terminally ill patients is rooted in the traditional hospital approach of treating everyone with intravenous fluids until they die. The hospice philosophy is that, as the former approach is seen to cause many problems for the terminally ill, giving no fluids at all would be the correct solution. 2 Both viewpoints are based on tradition and anecdotal reports, with conflicting case reports in the literature demonstrating the
Chronic Invalidism with Marked Personality Changes Due to Myxedema
Authors: HENRY F. STOLL
Journal: Annals of Internal Medicine (1932)

Article1 December 1932Chronic Invalidism with Marked Personality Changes Due to MyxedemaHENRY F. STOLL, M.D., F.A.C.P.HENRY F. STOLL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-6-806 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical aspect of myxedema was presented with such thoroughness by the special committee of the Clinical Society of London appointed in 1883 to study this disease that little if anything has been added to the clinical picture since that time. Among the 109 cases reviewed, it was found that slowness of thought and mental disorders of an irritable and suspicious character, with hebetude alternating with somnolence, were very common. Delusions and hallucinations occurred in one-half the cases and insanity was noted in about the same per cent. Acute or chronic mania and dementia were common with a marked predominance...References1 REPORT OF COMMITTEE ON MYXEDEMA: Trans. Clin. Soc. of London, 1888, Supplement to xxi. Google Scholar2 LUNDBENEDICT CCEB: Influence of thyroid gland on the action of morphine, New England Jr. Med., 1929, cci, 345-353. CrossrefGoogle Scholar3 BENEDICT EB: Morphine in myxedema, Jr. Am. Med. Assoc., 1930, civ, 1916. CrossrefGoogle Scholar4 DUDEN C: Myxedema with cardiac decompensation and hypertension which disappeared under thyroid medication, Jr. Mo. Med. Assoc., 1929, xxvi, 25-27. Discussion by David Barr. Google Scholar5 MASONHUNTHURXTHAL RLHMLM: Blood cholesterol values in hyperthyroidism and hypothyroidism: their significance, New England Jr. Med., 1930, cciii, 1273-1278. CrossrefGoogle Scholar6 WHITE PD: Heart disease, 1931, The Macmillan Company, New York, 388. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hartford, ConnecticutReceived for publication, December 18, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHypothyroidism: Does Treatment Cure Dementia?Thyroid disease and mental illness: A study of thyroid disease in psychiatric admissionsPsychiatric effects of thyroid hormone disturbanceMasked "myxedema madness"REVERSIBLE PSYCHOSIS AND DEMENTIA IN MYXEDEMANeurologic Manifestations of Myxedema 1 December 1932Volume 6, Issue 6Page: 806-814KeywordsBipolar disorderDementiaHallucinations Issue Published: 1 December 1932 PDF DownloadLoading ...
Your Heart and Common Sense
Authors: Vincent J. Gagliardi
Journal: JAMA (1964)

<h3>Your Heart Has Nine Lives: Nine Steps to Heart Health.</h3> By Alton Blakeslee and Jeremiah Stamler. 269 pp. $4.95. Prentice-Hall, Englewood Cliffs, NJ, 1963 <i>Your Heart and Common Sense</i>distills our knowledge about the heart and imparts it to the layman. In an effective introduction the reader learns first about structure and function, then about rheumatic and coronary heart disease, hypertension, heart failure, and other conditions. Chapters on drugs, diet, the digestive system, tools of cardiology, and general advice complete the book. In certain passages explanation blends effectively with description, philosophical reflections mingle well with rules of thumb, and the author achieves the style of a doctor talking to his patient. But the book lacks overall unity and balance. In recounting his lifetime of experience the author becomes expansive, inserting extraneous material which interferes with orderly transition and discourages the general reader. Heart patients can be urged to read some
Renal Excretion of Technetium-99m Diphosphonate in Osteomalacia
Authors: IGNAC FOGELMAN
Journal: Annals of Internal Medicine (1979)

Letters1 August 1979Renal Excretion of Technetium-99m Diphosphonate in OsteomalaciaIGNAC FOGELMAN, RODNEY G. BESSENTIGNAC FOGELMANSearch for more papers by this author, RODNEY G. BESSENTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-2-320_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article in the March 1979 issue by McFarlane and associates (1) in which 24-h renal excretion of technetium-99m diphosphonate was used as a measure of the whole-body retention in a patient with osteomalacia. Whole-body retention of diphosphonate at 24 h after injection reflects the total skeletal uptake of tracer and provides a simple method for assessing current skeletal metabolic activity (2). It is therefore of considerable clinical value, but we believe measuring the whole-body retention directly is important, because the accuracy of any urinary collection must always be suspect unless the patient...References1. MACFARLANE J, KHAIRI M, RICCIARDONE M, WELLMAN H, and JOHNSTON C. Renal excretion of 99mTc-diphosphonate in osteomalacia. Ann Int Med. 1979;90:350-1. LinkGoogle Scholar2. FOGELMAN I, BESSENT R, TURNER J, CITRIN D, BOYLE I, and GREIG W. The use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease. J Nucl Med. 1978;19:270-5. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: IGNAC FOGELMAN; RODNEY G. BESSENTAffiliations: University Departments of Medicine and Nuclear Medicine Royal Infirmary, Glasgow, G4 OSF Scotland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1979Volume 91, Issue 2Page: 320-321KeywordsExcretion ePublished: 1 December 2008 Issue Published: 1 August 1979 PDF downloadLoading ...
P51. Identification of prostate cancer-associated antigens by oxygen manipulation
Authors: T Ma, A Elkhattouti, F Kosari, RJ Karnes, JC Cheville, G Vasmatzis, S Vuk-Pavlovic, RC Gomez
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Therapeutic vaccination against prostate cancer (CaP) remains marginally effective. A reason for failure may stem from the fact that vaccine cells are usually cultured in ordinary air. Solid tumours including CaP contain regions with oxygen deficiency (hypoxia) secondary to the
ON CERTAIN BODIES FOUND IN SYPHILITIC LESIONS DEMONSTRATED BY THE JELLY METHOD
Authors: S. R. Moolgavkar
Journal: BMJ (1912)

Tlr. TT l 655 the corpuscles.The free granules, which are frequently to ba met with in pairs, each individual being apparently connected to its fellow by an invisible thread, are muich more highly refractile,vandoappear to exlhibit more umarked Browniaf movemient than do the fiee leucocyte granules and the, oher gianules.tobe fouiid in fre §h blood prepara- tions.-4inone -occasiorranpir of granules ihich were seen to escape from a free haimogregarine were found overnight to have taken up a position actually inside a neighlouring red blood corpuscle.Moreover, these two intracorpuscular granules were found to have divided into four between 10.30 a.m. and 4 p.m. of.the same day.*Theektrusion of these granules from the nucleuLs of the parasite, their.passage to -the postei5or extremity, and their liberation into the surrounding blood Dlasma, may be readily observed in films of fresh blood kept between slide and cover-slip, or in films made from blood lkept in tubes of Nicollos blood-agar medium: In the case of soles examined during May, 1911, granule formation occurred, as a rule, after the individual parasites 'had escaped from-the host cell, whereas witlh soles examined in September, 1912, granule formation was in most cases marked while the parasites were still intracorpusculr.In living blood the granules readily take on a red stain- ing with polychrome methylene blue, and the&y also take
The Six-City Study: examples of problems in analysis of the data.
Authors: B G Ferris, D W Dockery, J H Ware, F E Speizer, R Spiro
Journal: Environmental Health Perspectives (1983)

This paper presents some of the results from cross-sectional analyses and studies during air pollution alerts obtained as a part of the Six-City Study, a longitudinal study of the respiratory effects of air pollution. These analyses illustrate some of the limitations and uncertainties of epidemiologic studies. For example, an earlier report noted increased respiratory illness rates for children living in homes where gas was used for cooking. A later analysis did not confirm this. Reasons for this are explored by using different criteria and variables to be controlled for. The results illustrate that the strength of the association between cooking fuel and illness was sensitive to the definitions of the variables and the number of subjects and city cohorts. Similar examples are presented for illness rates for four respiratory diseases: asthma, bronchitis, illness before age 2 and illness last winter. These examples of cross-sectional analyses emphasize the ambiguities of studies of possible health effects of air pollution exposures close to the present ambient air quality standards.
Iron-Chelation Therapy with Oral Deferiprone — Toxicity or Lack of Efficacy?
Authors: Kris V. Kowdley, Marshall M. Kaplan
Journal: New England Journal of Medicine (1998)

Red-cell transfusion therapy in patients with homozygous β-thalassemia (thalassemia major) decreases the complications of severe anemia and prolongs survival.1 However, the effectiveness of transfusions is limited by the tissue damage resulting from iron overload, a consequence of the body's limited capacity to excrete iron. Each 250 ml of transfused red cells adds about 250 mg of elemental iron to the body. The end-organ manifestations of iron overload in patients with β-thalassemia — cirrhosis, hepatocellular carcinoma, cardiac failure, diabetes mellitus, and hypopituitarism — are similar to those in patients with hereditary hemochromatosis, and they shorten life expectancy.1 There is a direct . . .
Resuscitation From Ventricular Fibrillation
Authors: Joseph S. Redding
Journal: JAMA (1968)

In resuscitating dogs subjected to ten minutes of circulatory arrest due to ventricular fibrillation, a number of drugs were used with artificial ventilation of the lungs, external cardiac massage, and external electrical counter-shock. Resuscitation was more successful when epinephrine was used than when no drug therapy or sodium bicarbonate were used. Combination of lidocaine with epinephrine increased the frequency of defibrillation, but circulation was not restored more often than with epinephrine alone. The use of methoxamine hydrochloride was followed by successful resuscitation more often than was the use of epinephrine. Combination of epinephrine and sodium bicarbonate was as effective as methoxamine in restoring circulation, and inspection of the survivors after 24 hours suggested that the combination might be preferable.
Biphasic expression of stromal cell-derived factor-1 during human wound healing
Authors: A. Toksoy, V. Müller, R. Gillitzer, M. Goebeler
Journal: British Journal of Dermatology (2007)

Chemokines tightly regulate the spatial and temporal infiltration of invading leucocyte subsets during wound healing. Stromal cell-derived factor-1 (SDF-1/CXCL12) is a homeostatic chemokine with multiple functions; its role during cutaneous wound healing, however, needs to be explored.To elucidate expression of the multifunctional CXC chemokine SDF-1/CXCL12 during human wound healing.Skin biopsies were obtained from 14 volunteers between 1 and 21 days after incisional wounding and processed for in situ hybridization and immunohistochemistry.We analysed the spatial and temporal distribution of SDF-1/CXCL12 after artificial wounding and detected a complete downregulation at both the mRNA and the protein level within the fibrous stroma that replaces the initial wound defect. However, increased levels of SDF-1/CXCL12 were observed at the wound margins. Focusing on mediators regulating SDF-1/CXCL12 expression in vitro we realized that both tumour necrosis factor-alpha and interferon-gamma downregulated its expression in human dermal microvascular endothelial cells and fibroblasts.Our data suggest that SDF-1/CXCL12 is tightly regulated during wound repair. Increased expression at the wound margin may contribute to the accumulation of endothelial progenitor cells, thus accelerating neovascularization.
Are all born equal? Incidence of febrile convulsions by seasons of birth.
Authors: R Sunderland, R G Carpenter, A Gardner
Journal: BMJ (1982)

To test whether the seasons of birth had an effect on subsequent experience of illness, details were obtained of all Sheffield children born between 1973 and 1977 who were admitted to hospital before their second birthday with a first febrile convulsion. Analysis by date of birth in consecutive 28-day cohorts showed that the incidence of febrile convulsions ranged from 2.5 per thousand live births to 30.2 per thousand in different "month" cohorts. Statistically significant variations were noted in the incidence rates in relation to season and year of birth. The implication is that even large scale epidemiological studies which have been confined to children born in a particular week or month may not be representative of the whole child population.
Prevention and Early Detection Clinical Trials: Opportunities for Primary Care Providers and Their Patients
Authors: L. G. Ford, L. M. Minasian, W. McCaskill-Stevens, E. D. Pisano, D. Sullivan, R. A. Smith
Journal: CA A Cancer Journal for Clinicians (2003)

Enrollment into cancer prevention and early detection clinical trials represents a unique challenge compared with a diagnostic or treatment trial because it involves subjects without a diagnosis of cancer. This paper examines some of the barriers to participation in prevention and early detection trials and provides detailed information about two ongoing prevention and two ongoing early detection clinical trials open to enrollment as well as brief summaries of seven additional trials now open to enrollment.
Convinctions in sexual assault cases
Authors: Ronald C Denney
Journal: Journal of the Royal Society of Medicine (2007)

Beata Cybulska (JRSM 2007;100;321-324) has given a valuable insight into aspects of sexual assault, especially with respect to the low conviction rate for rape.

I am frequently called on to assess the validity of DNA data and analytical evidence for alcohol and drugs in such cases. Regrettably, it is clear that the low conviction rate occurs for a variety of reasons, not least the delay in the victim making a complaint to the police. But even with fairly rapid responses, cases fail for the following reasons:



The victim has washed or destroyed items of clothing or bed linen;


The victim has bathed or showered following the assault;


The victim was too intoxicated to remember many significant details of the events that occurred.






A very important point that must be considered is that after being sexually assaulted and/or raped the victim often feels traumatized, debased, contaminated and unclean and may develop a pathological desire to remove and wash away the effects and feelings from the sexual encounter. In many respects any significant increase in convictions for sexual assaults and rapes will only come about if it is possible to get the message across and widely accepted that women and men who are subjected to such offences should: complain quickly to the police, not wash or bathe before being medically examined, retain all items of clothing and bed linen, and try to provide as much fine detail about the assailant, the venue and the circumstances as possible.

That is asking a great deal from a person who has undergone such an indignity, but the greater the information available the better the chance of a conviction being possible.
Existence of Early-Onset NIDDM Japanese Demonstrating Severe Diabetic Complications
Authors: Hiroki Yokoyama, Maki Okudaira, Toshika Otani, Hiroko Takaike, Junnoske Miura, Akiko Saeki, Yasuko Uchigata, Yasue Omori
Journal: Diabetes Care (1997)

OBJECTIVE To identify the clinical characteristics of early-onset NIDDM patients with severe diabetic complications. RESEARCH DESIGN AND METHODS The clinical cases of a large number of diabetic patients who visited a diabetes center within the period 1970–1990 were reviewed. Of a total of 16,842 diabetic patients, 1,065 (6.3%) had early-onset NIDDM (diabetes diagnosed before 30 years of age). These 1,065 patients were divided into two groups, those who developed proliferative retinopathy before the age of 35 (n = 135) and those who did not (n = 930). Development of proliferative retinopathy, nephropathy, renal failure, blindness, and atherosclerotic vascular disease were compared between the two groups. RESULTS The subgroup of 135 patients was characterized by poor glycemic control, often requiring insulin therapy and a higher familial prevalence of diabetes, and contained a greater proportion of women than the subgroup of 930 patients. Of the 135 patients, 99 (67%) developed proliferative retinopathy before the first visit. The 135 patients developed severe progressive complications in contrast to the 930 patients. A total of 81 patients (60%) developed diabetic nephropathy at a mean age of 31 years, 31 (23%) developed renal failure requiring dialysis at a mean age of 35 years, 32 (24%) became blind at a mean age of 32 years, and 14 (10%) developed atherosclerotic vascular disease at a mean age of 36 years. CONCLUSIONS Some Japanese early-onset NIDDM patients develop severe diabetic complications in their youth. Most of them had no symptoms nor regular treatment regarding diabetes until they were noticed to have developed severe diabetic complications. Although the relevant prevalence and the pathogenetic mechanism underlying the rapid onset of the complications remain to be determined, prolonged inadequate treatment of and familial predisposition to diabetes may be contributing factors. Careful diabetes care in the twenties, not only for IDDM but also for NIDDM patients, is warranted.