tbuckley/cabot-search huggingface dataset:
DITTO-HCV early viral kinetics report - novel decline patterns in gen 1 but not gen 2–3 patients treated with PEG-interferon-alfa-2a and ribavirin
Authors: Avidan U. Neumann, Stefan Zeuzem, Carlo Ferrari, Yoav Lurie, Francesco Negro, George Germanidis, Juan Esteban, Kristoffer Hellstrand, Bertrand Pellegrin, Alexandre Soulier, Bart Haagmans, Sergio Abrignani, Giuseppe Colucci, Solko W. Schalm, Jean-Michel Pawlotsky
Journal: Journal of Hepatology (2002)
Prevalence of Age-Related Maculopathy and Age-Related Macular Degeneration among the Inuit in Greenland
Authors: Mads Varis Nis Andersen, Thomas Rosenberg, Morten la Cour, Jens F. Kiilgaard, Jan U. Prause, Poul Helge Alsbirk, Knut Borch-Johnsen, Tunde Peto, Bendix Carstensen, Alan C. Bird
Journal: Ophthalmology (2008)
POSTMORTEM OBSERVATIONS TWENTY YEARS AFTER BILATERAL MASTECTOMY
Authors: Bernard J. Ficarra
Journal: JAMA (1952)

A recent excellent article on the treatment of breast cancer has encouraged the presentation of this report. The case in question is one in which autopsy was performed by me in 1941. Prior to the presentation of the details of this case, mention will be made of several facts noted in the article previously mentioned.<sup>1</sup> There is some confusion about the best methods of treatment for cancer of the breast. Authors present statistics showing the survival rate of patients five years after operation. The cases usually are grouped into those in which radiation therapy was given either before or after mastectomy (or both) and those in which surgery alone (either simple or radical mastectomy) was performed. In the article mentioned above, the authors discuss a patient with advanced cancer who was subjected to surgery and was well 14 years after mastectomy (no mention is made of radiation therapy). These
Keeping NF-κB in check
Authors: Ruth Williams
Journal: The Journal of Experimental Medicine (2006)

![Graphic][1] 

Cells lacking TRAF3 constitutively release active p52 NF-κB. NF-κB, a central proinflammatory regulator, gets activated by TNF receptor–associated factors (TRAFs). But He et al. (page 

[2413][2]) now report that one TRAF family member (TRAF3) instead negatively
Oral Contraceptives and Proof of Drug Safety
Authors: MONROE COLE
Journal: Annals of Internal Medicine (1969)

Editorial Notes1 April 1969Oral Contraceptives and Proof of Drug SafetyMONROE COLE, M.D., F.A.C.P.MONROE COLE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-4-868 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAre oral contraceptive hormones potentially harmful? The question, important enough itself, is related to the greater problem of proving the safety of any widely used drug or treatment. The problem of oral contraceptives is unique in that a large portion of the healthy population is "treated" despite availability of adequate, albeit inconvenient, methods to achieve the same end. The argument that pregnancy itself bears risks to health is a sophism because the use of contraceptive hormones is not the only way to prevent pregnancy.Numerous medical problems have been reported in patients using oral contraceptive hormones, the most serious of...References1. REEDCOAN DLWW: Thrombo-embolism in patients receiving progestational drugs. New Eng. J. Med. 269: 622, 1963. CrossrefMedlineGoogle Scholar2. ASK-UPMARK E: Thrombo-embolism and oral contraceptives: post or propter. Acta Med. Scand. 179: 463, 1966. CrossrefMedlineGoogle Scholar3. COLE M: Strokes in young women using oral contraceptives. Arch. Intern. Med. (Chicago) 120: 551, 1967. CrossrefMedlineGoogle Scholar4. WALSHCLARKTHOMPSONNICHOLSON FBDBRSDH: Oral contraceptives and neuro-ophthalmologic interest. Arch. Ophthal. (Chicago) 74: 628, 1965. CrossrefMedlineGoogle Scholar5. URBANFRANKKERN EBWF: Liver dysfunction with mestranol but not with norethynodrel in a patient with Enovid®-induced jaundice. Ann. Intern. Med. 68: 598, 968. LinkGoogle Scholar6. PORTERA A: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Neurology Bowman Gray School of Medicine of Wake Forest University Winston-Salem, N. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBibliography 1 April 1969Volume 70, Issue 4Page: 868-868KeywordsContraceptivesDrug safetyDrugsHormonesOral contraceptive therapyOral healthPregnancySafety Issue Published: 1 April 1969 PDF DownloadLoading ...
A STATISTICAL STUDY OF THE ADMISSION OF ALCOHOLIC PATIENTS TO A LARGE MENTAL HOSPITAL
Authors: PAUL E. FELDMAN, ELIAS COHEN
Journal: American Journal of Psychiatry (1955)

1. Male alcoholic admissions outnumber females 4 to 1. 2. One of each 4 male alcoholic admissions comes in voluntarily. One of each 8 female alcoholic admissions does so. 3. Sixty-one per cent of all male alcoholics were classified "with psychosis"; 76% of all female alcoholics were so classified. 4. The percentage of voluntary admissions for both sexes increases significantly with the frequency of admission. 5. The percentage of patients classified "with psychosis" increases in voluntary male admissions with the frequency of admission: 20-26-69-50-86%. The percentage of patients dagnosed "with psychosis" remains fairly stable in committed male admissions: 69-71-50-66-66%. The percentage of pa- tients classified "with psychosis" remains uniformly high in all female admissions: 65 to 90%. 6. Of 32 admissions classified "acute hallucinoisis" (male and female), only 2 were voluntary. 7. Of 21 patients classified "delirium tremens" (male and female), only 1 was voluntary. 8. Of 43 patients classified "with other forms of alcoholic psychosis" (chiefly pathological intoxication), only 3 were voluntary. 9. Of 245 patients classified "psychosis, alcoholic deterioration" (male and female), 42 were voluntary admissions. 10. Of 184 patients classified "without psychosis" (male and female), 63 were voluntary.
TCR-Vβ repertoire analysis with RT-PCR was useful for the early detection of pulmonary relapsed T-cell lymphoma after autologous peripheral blood stem cell transplantation
Authors: Hidenori Hase, Kenzaburo Tani, Hitomi Nagayama, Kiyoshi Watari, Satoshi Takahashi, Jun Ooi, Naoki Shirafuji, Tohru Iseki, Yukoh Nakazaki, Takayuki Yamashita, Tetsuya Nakamura, Atsuko Masunaga, Taira Maekawa, Arinobu Tojo, Shigetaka Asano
Journal: American Journal of Hematology (2000)

Pulmonary recurrence of malignant lymphoma is a rare event after stem cell transplantation. We report here a 45-year-old male who was successfully diagnosed with relapsed pulmonary T-cell lymphoma using an RT-PCR method. Clonal expansion of T cells expressing identical TCR V-D-J junction size (Vβ5-Jβ1.5) was demonstrated in lymphocyte groups obtained from both bronchoalveolar lavage fluid at relapse, and paraffin embedded lymph node samples resected when he was first diagnosed with angioimmunoblastic T-cell lymphoma. This method provided evidence to diagnose relapsed pulmonary angioimmunoblastic T-cell lymphoma in its early phase. Am. J. Hematol. 64:124–127, 2000. © 2000 Wiley-Liss, Inc.
Too many advisers, not enough aid.
Authors: K. Chopin
Journal: BMJ (1992)

ConclusionThe most remarkable advance in therapeutic oncology during the past 10-15 years has been in the treatment of germ cell tumours.A high proportion of patients with these cancers are now entered into large cooperative clinical trials, which hold the key to improvements in management in the future.These tumours are diverse and their, management complex; referral to specialist oncology centres with the wide range of expertise necessary to treat these fascinating neoplasms should be considered in all cases.
Should inpatient hyperglycaemia be treated?
Authors: K. Dhatariya
Journal: BMJ (2013)

Two large scale randomised controlled trials in the 1990s were the first such trials to show that the control of blood glucose helped to prevent long term complications in people with types 1 and 2 diabetes.1 2 Glucose concentrations can rise not only in people with pre-existing diabetes, but also, for short periods, in people without the condition—in particular, during times of acute illness, when it is called stress hyperglycaemia.3 As discussed below, data show that raised blood glucose concentrations in people with and without a previous diagnosis of diabetes are associated with short term harm. However, whereas the benefits of good glycaemic control over a long period in people with diabetes are well established, uncertainty remains about whether treating transient hyperglycaemia, in particular in hospital inpatients, makes any difference to short term outcomes.

Sometimes the question is moot and treating hyperglycaemia is crucial—for example, in diabetic ketoacidosis or hyperosmolar hyperglycaemic states4 or in patients who are symptomatic from their hyperglycaemia. This article does not discuss these states.

I searched PubMed, the Cochrane Library, and Clinical Evidence to identify publications that concerned the outcomes of hyperglycaemia in hospital inpatients and those that dealt with treating the hyperglycaemia. Since the two trials in the 1990s,1 2 other studies have also shown that hyperglycaemia in inpatients with and without pre-existing diabetes is associated with poor outcomes. However, most trials were observational, with only a few randomised controlled trials. A meta-analysis of 34 randomised control trials assessing perioperative insulin infusion in 2192 surgical patients concluded that “perioperative insulin infusion may reduce mortality but increases hypoglycaemia in patients who are undergoing surgery.”5 However, only 14 of these studies included patients with diabetes, with 13 studies excluding them and …
Early Primary Care Provider Follow-up and Readmission After High-Risk Surgery
Authors: Benjamin S. Brooke, David H. Stone, Jack L. Cronenwett, Brian Nolan, Randall R. DeMartino, Todd A. MacKenzie, David C. Goodman, Philip P. Goodney
Journal: JAMA Surgery (2014)

Follow-up with a primary care provider (PCP) in addition to the surgical team is routinely recommended to patients discharged after major surgery despite no clear evidence that it improves outcomes.To test whether PCP follow-up is associated with lower 30-day readmission rates after open thoracic aortic aneurysm (TAA) repair and ventral hernia repair (VHR), surgical procedures known to have a high and low risk of readmission, respectively.In a cohort of Medicare beneficiaries discharged to home after open TAA repair (n = 12 679) and VHR (n = 52 807) between 2003 to 2010, we compared 30-day readmission rates between patients seen and not seen by a PCP within 30 days of discharge and across tertiles of regional primary care use. We stratified our analysis by the presence of complications during the surgical (index) admission.Thirty-day readmission rate.Overall, 2619 patients (20.6%) undergoing open TAA repair and 4927 patients (9.3%) undergoing VHR were readmitted within 30 days after surgery. Complications occurred in 4649 patients (36.6%) undergoing open TAA repair and 4528 patients (8.6%) undergoing VHR during their surgical admission. Early follow-up with a PCP significantly reduced the risk of readmission among open TAA patients who experienced perioperative complications, from 35.0% (without follow-up) to 20.4% (with follow-up) (P < .001). However, PCP follow-up made no significant difference in patients whose hospital course was uncomplicated (19.4% with follow-up vs 21.9% without follow-up; P = .31). In comparison, early follow-up with a PCP after VHR did not reduce the risk of readmission, regardless of complications. In adjusted regional analyses, undergoing open TAA repair in regions with high compared with low primary care use was associated with an 18% lower likelihood of 30-day readmission (odds ratio, 0.82; 95% CI, 0.71-0.96; P = .02), whereas no significant difference was found among patients after VHR.Follow-up with a PCP after high-risk surgery (eg, open TAA repair), especially among patients with complications, is associated with a lower risk of hospital readmission. Patients undergoing lower-risk surgery (eg, VHR) do not receive the same benefit from early PCP follow-up. Identifying high-risk surgical patients who will benefit from PCP integration during care transitions may offer a low-cost solution toward limiting readmissions.
Inherited arrhythmias in the dog potential experimental models of cardiac disease
Authors: N Moïse
Journal: Cardiovascular Research (1999)

Centuries of inbreeding the domestic dog has resulted in numerous spontaneous breed-specific and familial diseases of all body systems [1]. Although few animal models of spontaneous arrhythmic death exists [2] veterinary cardiologists have recognized potentially inherited arrhythmias in the dog for years. The purpose of this paper is to describe the proven inherited, and the likely inherited, arrhythmias diagnosed commonly in the dog with the intent to provide information of potential models for investigation of primary arrhythmias. Additionally, examples of common arrhythmias that are secondary to inherited cardiac disease in the dog will be provided.
Restrictions on Doctor in South Africa
Authors: None Adrian, D. Baird, B. N. Brooke, G. M. Carstairs, R. Doll, D. Doniach, A. I. Friedmann, P. D. Hart, D. Krikler, J. E. Lennard-Jones, B. Lewis, E. Miller, J. S. Mitchell, L. H. Opie, T. R. E. Pilkington, None Platt, A. Sorsby, J. Waterlow
Journal: BMJ (1967)

a research worker of international standing
The Chemistry of Lipids in Health and Disease: A Review of Our Present Knowledge of Lipids; Their Chemical Structure; Their Breakdown and Synthesis in Living Organisms; Their Place in Human Nutrition; and Their Abnormalities of Metabolism in Disease
Authors: Lawrence C. Parish
Journal: JAMA (1960)

Lipids were one of the more neglected aspects of biochemical knowledge until recent times. There were many gaps in the understanding of lipid metabolism and its relationship to disease. Most textbooks and many biochemists, even today, present a sketchy and often erroneous picture of lipids. This monograph does an outstanding job of reporting up-to-date information on lipid chemistry and metabolism and their connection with medicine. As the author has pointed out about his well-written and excellently diagramed book, the "aim is not to influence the reader's judgment, but to give him a background against which he can read and judge current literature, and himself pass judgment on present and future concepts." I found no errors or any contradictory sections according to currently accepted biochemical beliefs. Although steroid hormones are treated in a separate volume of the "American Lecture Series," both the practicing physician and the student should find their time
IgE, IgA, and IgG responses to common yeasts in atopic patients
Authors: J. Savolainen, O. Kortekangas‐Savolainen, M. Nermes, M. Viander, A. Koivikko, K. Kalimo, E. O. Terho
Journal: Allergy (1998)

This study was undertaken to analyze the differences in exposure and sensitization to five common environmental yeasts. The responses of IgG, IgA. and IgE to Candida albicans. C. utilis, Cryptococcus albidus, Rhodotorula rubra , and Saccharomyces cerevisiae and purified S. cerevisiae enolase were analyzed by immunoblotting (IgE‐1B), and the cross‐reactivity of their IgE‐binding components by IgE‐1B inhibition. Twenty atopic subjects, with asthma, allergic rhinitis, or atopic dermatitis were included. In skin prick tests (SPT), 12 of the patients showed simultaneous reactivity to at least two of the five yeasts, four reacted to one of the yeasts, and four had no responses. Antigens run in SDS‐PAGE and transferred to nitrocellulose were probed with enzyme‐labeled IgA‐, IgG‐, and IgE‐specific antibodies. The IgE immunoblotting revealed most IgE‐binding bands in C. albicans (11 bands) followed by C. utilis (eight bands), S. cerevisiae (five bands), R. rubra (five bands), and Cr. albidus (four bands). Six of the IgE‐binding bands of C. albicans and C. utilis shared molecular weight, and only two bands shared molecular weight with other yeasts. These were the 46‐kDa band, shared by all five yeasts, and a 13‐kDa band shared by four yeasts. Prominent IgE binding was seen to a 46‐kDa band of C. albicans (seven patients), C. utilis (five patients), and S. cerevisiae (one patient) and to corresponding weak bands of Cr. albidus and R. rubra (one patient). The possible cross‐reactivity of the 46‐kDa band was analyzed by IgE‐IB inhibition and densitometry, revealing clear C albicans inhibition of C. utilis (80%) and enolase (98%) (autoinhibition 100%). The strongest IgG responses were seen against S. cerevisiae and C albicans. The responses were mainly against mannans of C. albicans and S. cerevisiae , suggesting that most of the exposure is to these yeasts. Yeasts with different types of exposure, from saprophytic growth on human mucous membranes to exposure by air and food, were shown to cross‐react at the allergenic level. Atopic patients primarily sensitized by C albicans and S. cerevisiae may develop allergic symptoms by exposure to other environmental yeasts due to cross‐reacting IgE antibodies.
313 CARDIOTROPHIN-1 (CT-1) PLAYS A KEY ROLE IN ENHANCING ANTIAPOPTOTIC DEFENSES AND MAINTAINING MITOCHONDRIAL FUNCTION DURING LIVER REGENERATION
Authors: E. Santa María, S. Garate, E. Ibáñez, M. Íniguez, E. Martínez, A. Morales, J.C. Fernández-Checa, M. Bustos, J. Prieto Valtueña
Journal: Journal of Hepatology (2013)
Von willebrand disease with an increased ristocetin‐induced platelet aggregation and a qualitative abnormality of the factor VIII protein
Authors: Hoyu Takahashi, Nobuo Sakuragawa, Akira Shibata
Journal: American Journal of Hematology (1980)

Abstract Two cases of von Willebrand disease (VWD) that revealed an increased ristocetin‐induced platelet aggregation (RIPA) and a qualitative abnormality of the factor VIII protein are reported. The threshold concentration of ristocetin giving a 30% increase in light transmission was 0.5 mg/ml in the proband and 0.4 mg/ml in her father (normal: 1.16 ± SD 0.18 mg/ml) although both patients showed reduced plasma von Willebrand factor activity (VIIIR:WF). In both patients, the amount of factor VIII related antigen (VIIIR:AG) in their platelets were normal, but an increased binding affinity of platelets to plasma factor VIII was demonstrated. The qualitative abnormality of the factor VIII protein was characterized by an increased anodal migration of VIIIR:AG in crossed immunoelectrophoresis (CIE), a delayed elution pattern as demonstrated by gel filtration on Sepharose 2B, and a decreased precipitation with concanavalin A (Con A). The response to DDAVP was also investigated.
Empiric Use of Aminoglycosides in Hospitals
Authors: PETER MANU
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 June 1984Empiric Use of Aminoglycosides in HospitalsPETER MANU, M.D.PETER MANU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-6-919_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Amikacin, a semisynthetic derivative of kanamycin A, was approved for unrestricted clinical use in 1976 and is considered the antibiotic of choice for use against infections with gentamicin-resistant, gram-negative bacilli (1, 2). In a recent issue, Betts and colleagues (3) have reported data on the use of amikacin as the primary empiric aminoglycoside in a large university hospital. The authors have concluded that "because it is not possible to identify patients infected with gentamicin-resistant organisms until 48 hours after therapy is initiated, it is rational to use an antibiotic agent that is likely to be effective against...References1. MEYER R. Amikacin. Ann Intern Med. 1981;95:328-32. LinkGoogle Scholar2. EDSONKEYS RT. The aminoglycosides. Mayo Clin Proc. 1983;58:99-102. MedlineGoogle Scholar3. BETTSVALENTICHAPMAN RWS. Five-year surveillance of aminoglycoside usage in a university hospital. Ann Intern Med. 1984;100:219-22. LinkGoogle Scholar4. INGELFINGERMOSTELLERTHIBODEAUWARE JFLJ. Biostatistics in Clinical Medicine. New York: MacMillan Publishing Co., Inc.; 1983:177-99. Google Scholar5. GARIBALDIBRODINEMATSUMIYA RSS. Infections among patients in nursing homes: policies, prevalence and problems. N Engl J Med. 1981;305:731-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMinimizing Antimicrobial Resistance in Hospital Bacteria: Can Switching or Cycling Drugs Help? 1 June 1984Volume 100, Issue 6Page: 919-920KeywordsAntibioticsResearch design Issue Published: 1 June 1984 PDF DownloadLoading ...
Intensive BP control and/or glucose control did not reduce microvascular events in hypertensive type 2 diabetes
Authors: Juan P. Brito, Victor M. Montori
Journal: Annals of Internal Medicine (2012)

Source Citation Ismail-Beigi F, Craven TE, O’Connor PJ, et al; ACCORD Study Group. Combined intensive blood pressure and glycemic control does not produce an additive benefit on microvascular outcomes in type 2 diabetic patients. Kidney Int. 2012;81:586-94. 22166848
AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice
Authors: Julie M. Crudele, Jonathan D. Finn, Joshua I. Siner, Nicholas B. Martin, Glenn P. Niemeyer, Shangzhen Zhou, Federico Mingozzi, Clinton D. Lothrop, Valder R. Arruda
Journal: Blood (2015)
Association between Transcriptional Activity, Local Chromatin Structure, and the Efficiencies of Both Subpathways of Nucleotide Excision Repair of Melphalan Adducts
Authors: Hara Episkopou, Soterios A. Kyrtopoulos, Petros P. Sfikakis, Maria Fousteri, Meletios A. Dimopoulos, Leon H.F. Mullenders, Vassilis L. Souliotis
Journal: Cancer Research (2009)

The repair of melphalan-induced N-alkylpurine monoadducts and interstrand cross-links was examined in different repair backgrounds, focusing on four genes (beta-actin, p53, N-ras, and delta-globin) with dissimilar transcription activities. Adducts were found to be substrates for both global genome repair (GGR) and transcription-coupled repair (TCR), with TCR being less efficient than GGR. In nucleotide excision repair-deficient cells, adducts accumulated to similar levels in all four genes. The repair efficiency in different gene loci varied in a qualitatively and quantitatively similar way in both GGR-deficient and TCR-deficient backgrounds and correlated with transcriptional activity and local chromatin condensation. No strand-specific repair was found in GGR(+)/TCR(+) cells, implying that GGR dominated. Adducts were lost over two sharply demarcated phases: a rapid phase resulting in the removal within 1 hour of up to approximately 80% of the adducts, and a subsequent phase with t(1/2) approximately 36 to 48 hours. Following pretreatment of cells with alpha-amanitin, the rate of transcription, the state of chromatin condensation, and the repair efficiencies (both TCR and GGR) of the transcribed beta-actin, p53, and N-ras genes became similar to those of the nontranscribed delta-globin gene. In conclusion, a continuous, parallel variation of the state of transcription and local chromatin condensation, on one hand, and the rates of both GGR and TCR, on the other hand, have been shown.