tbuckley/cabot-search huggingface dataset:
Renal Fat Emboli, Maltese Crosses, and Heart Surgery
Authors: Stanley M. Lee
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We observed numerous large fat particles in the urine of a patient several hours after placement of an artificial heart. The significance of this phenomenon and its relationship to post-cardiopulmonary bypass renal insufficiency remains undetermined. We therefore prospectively studied ten patients undergoing heart surgery requiring cardiopulmonary bypass. The patients ranged in age from 18 months to 75 years. The most common operations were coronary bypass or valve replacement. Preoperative urinalysis was performed to exclude the presence of proteinuria or oval fat bodies. None of the patients had hyperlipidemia. The urine specimens were examined by phase and polarized microscopy. Postoperative urine specimens were obtained at periods ranging from one to seven hours following completion of cardiopulmonary bypass. In seven of ten patients, large fat bodies were observed. These particles were highly refractile and in polarized light had a typical "maltese cross" appearance and ranged in size from approximately
Plasma levels of activated protein C-protein C inhibitor complex in patients with hypercoagulable states
Authors: Rika Watanabe, Hideo Wada, Miho Sakakura, Yoshitaka Mori, Takahiro Nakasaki, Yoshinaga Okugawa, Esteban C. Gabazza, Tatsuya Hayashi, Junji Nishioka, Koji Suzuki, Hiroshi Shiku, Tsutomu Nobori
Journal: American Journal of Hematology (2000)

Plasma levels of activated protein C (APC)–protein C inhibitor (PCI) were significantly increased in patients with disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), acute myocardial infarction (AMI), pulmonary embolism (PE), or deep vein thrombosis (DVT) and in patients undergoing hemodialysis (HD). Plasma levels of APC–α1-antitrypsin (AT) complex were significantly increased in patients with DIC and in those with TTP. Plasma levels of PCI were significantly decreased in patients with DIC, non-DIC, or TTP and in those undergoing HD. In the pre-DIC stage, the plasma levels of APC–PCI complex were significantly increased but not those of APC–α1-AT complex. These data suggest that measurements of APC–PCI complex and APC–α1-AT complex may be useful for the diagnosis of DIC. After treatment of DIC, the plasma levels of APC–PCI complex and APC–α1-AT complex were significantly decreased, but not those of PCI. Plasma levels of thrombin–antithrombin complex (TAT), plasmin–α2-plasmin complex (PPIC), D-dimer, and soluble fibrin monomer (SFM) were markedly increased in patients with DIC or pre-DIC and were moderately increased in patients with non-DIC, TTP, AMI, PE, or DVT and in those undergoing HD. The receiving operating characteristic (ROC) analysis showed that SFM and the APC–PCT complex are useful markers for diagnosis of DIC. The specificity of plasma TAT and PPIC levels was low. The positive rate of APC–PCI complex was higher than 90% with DIC, TTP, AMI, PE, and it was higher than 60% with DVT and HD. Since the APC–PCI complex was elevated not only in patients with venous thrombosis but also in those with arterial thrombosis, components of the protein C pathway might be useful markers for the diagnosis of arterial thrombosis. Am. J. Hematol. 65:35–40, 2000. © 2000 Wiley-Liss, Inc.
Cardiogenic shock. Treatment by augmentation with a pulsatile assist device
Authors: S. J. Phillips
Journal: JAMA (1978)

INTRA-AORTIC balloon pumping has become an accepted mode of threapy for treatment of complicated myocardial infarction.<sup>1,2</sup>A percentage of patients who would benefit from intra-aortic balloon pumping cannot have the procedure applied by way of the femoral artery because of severe arteriosclerotic occlusive disease. This can prevent passage of the balloon or result in complications of insertion.<sup>3-5</sup>A small group of patients in whom intra-aortic balloon pump can be applied experiences varying degrees of ischemic neuropathy in the leg in which the balloon was inserted. This occurs because subluminal occlusion of the balloon catheter in the femoral artery reduces the flow through that leg. A pulsatile assist device (PAD) was used for diastolic augmentation in a patient in whom an intra-aortic balloon pump could not be inserted.<sup>6,7</sup> <h3>Report of a Case</h3> A 69-year-old man was transferred from another hospital to Mercy Hospital, Des Moines, Iowa, for intra-aortic
Effect of Estrogen/Progestin Potency on Lipid/Lipoprotein Cholesterol
Authors: Patricia Wahl, Carolyn Walden, Robert Knopp, Joanne Hoover, Robert Wallace, Gerardo Heiss, Basil Rifkind
Journal: New England Journal of Medicine (1983)

We studied 374 women taking oral contraceptives, 284 women taking estrogen preparations after menopause, and 1086 women taking no hormones, to determine the relation of plasma lipids and lipoprotein cholesterol concentrations to various types of estrogen/progestin formulations. Premenopausal women, using oral contraceptives containing a relatively low dose of estrogen combined with a medium or high dose of progestin (Norlestrin, Ovral, or Demulen) had a 24 per cent higher median concentration of low-density-lipoprotein cholesterol than did those not using hormones (P less than 0.05). Women using oral contraceptives that are high in estrogen and low in progestin (Enovid or Oracon) had significantly higher concentrations of high-density-lipoprotein cholesterol than did nonusers; those using Ovral, a low-estrogen and high-progestin formulation, had significantly lower levels of high-density-lipoprotein cholesterol. In postmenopausal women the use of estrogen was associated with concentrations of low-density-lipoprotein cholesterol that were 11 to 19 per cent below the levels in postmenopausal women who did not use hormones. The effects of estrogen-progestin balance on low-density and high-density lipoproteins may underlie the increased incidence of stroke and myocardial infarction in women of childbearing age who take oral contraceptives.
Regression of CD8+ pseudolymphoma after HIV antiviral triple therapy
Authors: Nol Emile Clestin Schartz, Arnaud De La Blanchardire, Siham Alaoui, Patrice Morel, Franois Sigaux, Marie-Dominique Vignon-Pennamen, Batrice Flageul, Cleste Lebb
Journal: Journal of the American Academy of Dermatology (2003)
STUDIES IN FAT METABOLISM. III. THE EFFECT OF ACTH, OF CORTISONE, AND OF OTHER STEROID COMPOUNDS UPON FASTING-INDUCED HYPERKETONEMIA AND KETONURIA 123
Authors: Laurance W. Kinsell, Sheldon Margen, George D. Michaels, Robert Reiss, Robert Frantz, John Carbone, Judith Lange, Gerald Liebert
Journal: Journal of Clinical Investigation (1951)
Adult Hemolytic-Uremic Syndrome.
Authors: J. Drewry
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Adult Hemolytic-Uremic Syndrome.J. Drewry, M.D., A. C. Alfrey, M.D., A. R. Hull, M.D.J. Drewry, M.D.Search for more papers by this author, A. C. Alfrey, M.D.Search for more papers by this author, A. R. Hull, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-830_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThree patients with adult hemolytic-uremic syndrome manifested by anuria, thrombocytopenia, red cell fragmentation, and increased fibrin split products were studied with serial renal biopsies and coagulation studies. Onset of disease occurred in the early postpartum period in two patients and during anovulatory therapy in the third. Renal biopsy showed endothelial proliferation and fibrin deposition in the lumen and walls of small and medium-sized arteries. Immunofluorescence staining showed fibrin, betal1C, and gamma globulin in vessel walls. Renal vein catheterization failed to demonstrate a gradient across the kidney for platelets, fibrinogen, or fibrin split products. Two patients were maintained on continuous intravenous... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. Drewry, M.D.; A. C. Alfrey, M.D.; A. R. Hull, M.D.Affiliations: Dallas, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 830-831KeywordsBiopsyCatheterizationFibrinFibrinogenGlobulinsHemolytic-uremic syndromeImmunofluorescence stainingKidneysPlateletsVeins ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
Bacteria Versus Antibiotics: Who Is Winning?
Authors: Julian Davies
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Bacteria Versus Antibiotics: Who Is Winning?Julian Davies, M.D.Julian Davies, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-813_6 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe continued use of antibiotics in clinical practice has provided strong pressure for the selection of bacteria resistant to these antibiotics. The bacterial strains generally owe their resistance characteristics to genetically transmissible agents called R-factors. Studies have shown that R-factors determine the synthesis of several enzymes that specifically inactivate antibiotics. The enzymatic inactivations often give rise to cross-resistance to several antibiotics because the enzymes can use structural elements common to several antibiotics as their substrates. The introduction of new antibiotics that lack these structural elements has provided agents active against some resistant bacterial strains. Once again, however, the selection of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Julian Davies, M.D.Affiliations: Madison, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 813-813KeywordsAntibioticsBacteriaEnzymes ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
Is there a link between cot death and child abuse?
Authors: J Roberts, J Golding, J Keeling, B Sutton, M A Lynch
Journal: BMJ (1984)

Forty five babies delivered in Oxford obstetric units who subsequently died unexpectedly in infancy were compared with 134 controls matched for maternal age, social class, parity, and year of birth to see whether five factors identified in an earlier study as predictive of subsequent child abuse would also predict the sudden infant death syndrome. Epidemiological findings had suggested certain similarities between the two events. In contrast with babies who were abused, four of the five factors did not distinguish between babies who died suddenly and unexpectedly and their controls, but there was a slight increase in the proportion of mothers of babies who died suddenly and unexpectedly for whom nursing staff thought that support and advice on feeding the baby were needed. Factors predictive of child abuse did not predict sudden infant death in this study.
Efficacy of Sr-90 beta radiation for the treatment of in-stent restenosis: 24-month clinical outcomes from the STents and Radiation Therapy Trial (START)
Authors: Warren K. Laskey, Mohan Suntharalingam, Jeffrey Popma, Richard Heuser, Barry Rutherford, Paul Teirstein, Alexandra Lansky, Richard Kuntz, Raoul Bonan
Journal: Journal of the American College of Cardiology (2002)
Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes
Authors: Meng Meng, Yu Liu, Yi-Bo Wang, Jian-Cheng Wang, Hua Zhang, Xue-Qing Wang, Xuan Zhang, Wan-Liang Lu, Qiang Zhang
Journal: Journal of Controlled Release (2008)
Measles eradication policies.
Authors: N D Noah
Journal: BMJ (1982)

coxiella prosthetic endocarditis seems to be curable medically; this indolent infection by cell-dependent organisms was previously thought to incurable except by surgical excision combined with tetracycline treatment.Despite this awesome list of causes of disaster most patients with artificial valves are tolerably pleased.The long-term results of aortic valve replacement with a mechanical valve are usually first class, and the more mixed results of mitral and multiple valve replacement are now at least better understood.
Effects of Dietary Energy Restriction on Gene Regulation in Mammary Epithelial Cells
Authors: Zongjian Zhu, Weiqin Jiang, John N. McGinley, Jennifer M. Price, Bifeng Gao, Henry J. Thompson
Journal: Cancer Research (2007)

The objective of this study was to determine whether dietary energy restriction (DER) affects the pattern of gene expression in three interrelated energy metabolism pathways: glycolysis, gluconeogenesis, and the citric acid cycle. Mammary carcinogenesis was initiated by the i.p. injection of female Sprague-Dawley rats with 50 mg of 1-methyl-1-nitrosourea per kilogram of body weight. Five days following 1-methyl-1-nitrosourea administration, animals were fed ad libitum or 80% or 60% of the ad libitum intake. Epithelial cells were harvested from histologically confirmed adenocarcinomas (adenocarcinoma epithelial cell; ACEC) and uninvolved mammary gland (mammary gland epithelial cells; MGEC) via laser capture microdissection, whereas isolated RNA was arrayed on Affymetrix R230 2.0 genome chips. Principal components analysis revealed complete separation of the patterns of gene expression between ACEC versus MGEC. Further examination of the data set revealed an up-regulated pattern of expression in the ACEC of genes involved in glycolysis, whereas gluconeogenesis was suppressed. In general, genes involved in the citric acid cycle were not differentially expressed; however, pyruvate dehydrogenase expression was down-regulated and lactate dehydrogenase expression was increased in ACEC versus MGEC. Collectively, the observed patterns of expression were consistent with the Warburg effect. DER exerted no effect on the Warburg pattern of gene expression or on other aspects of these energy metabolism pathways. These findings imply that efforts to target the Warburg effect for cancer prevention are mechanistically distinct from those modulated by DER and provide a rationale for the combination of approaches that target basic defects in energy metabolism and energy-sensing pathways for the prevention of breast cancer.
Death from Pistol-Shot Wounds: Suicide or Homicide?
Authors: A. A. Bowlby
Journal: BMJ (1885)

enlarged; there may be dropsy of the legs, and some albumen in the urine.In the first case, in spite of the lividity of the skin, the congestion, as seen by its effects on the organs, is not nearly so great as in the second, or cardiac case.I take the case of mitral disease, for in aortic, when the blood is thrown back on the heart, the body is pale and impoverished, and it is not until the mitral valve gives way
An Address Delivered at the Opening of the Section of Diseases of the Teeth
Authors: E. Saunders
Journal: BMJ (1881)

GENTLEMEN,-Before assuming the duties and responsibilities of President of the Odontological Section of this great Congress, permit me to thank you for the honour you have conferred upon me in electing me to that high office; and let me assure you that it will be my earnest endeavour to justify your choice, however I may fail to satisfy my own, and your, well-warranted expectations.And, indeed, were it not that I am sustained by the kind co-operation of two vice-presidents and a secretary, in whom our profession feels a just and legitimate pride, I might well feel oppressed by the onus of doing full justice to the posi- tion on so august an occasion.Nor was it, I am free to admit, until I had the permission of the Executive Committee to call around me, as a Council, some old and tried associates in professional work, that I began to experience the requisite energy and confidence.And having made this personal avowal and confession, I turn to the distinguished com- pany before me, who have done us the high honour to visit our too great, but not too gay, capital, and to become for a too short time, and for our signal profit, our guests at this great intellectual banquet.Permit me, gentlemen, on behalf of the English members of the Con- gress, on behalf of our largest society, the Odontological Society of Great Britain, now in the twenty-fifth year of its somewhat chequered, bu, on the whole, prosperous existence, and on behalf of the whole body of the dental profession in England, to offer you a hearty welcome, and to assure you of our earnest desire to render your too brief visit both profitable and pleasant.We hail the happy occasion of our friendly intercourse, and we trust that friendships begun under such benign auspices may continue and progress in interest through many pros- perous years.Such gatherings as these, with the pleasurable amenities they involve, do much to soften and refine the manners, to quicken the
Antigen-dependent and -independent Ca2+ Responses Triggered in T Cells by Dendritic Cells Compared with B Cells
Authors: Jérôme Delon, Nadège Bercovici, Graça Raposo, Roland Liblau, Alain Trautmann
Journal: The Journal of Experimental Medicine (1998)

Dendritic cells (DCs) are much more potent antigen (Ag)-presenting cells than resting B cells for the activation of naive T cells. The mechanisms underlying this difference have been analyzed under conditions where ex vivo DCs or B cells presented known numbers of specific Ag–major histocompatibility complex (MHC) complexes to naive CD4+ T cells from T cell antigen receptor (TCR) transgenic mice. Several hundred Ag–MHC complexes presented by B cells were necessary to elicit the formation of a few T–B conjugates with small contact zones, and the resulting individual T cell Ca2+ responses were all-or-none. In contrast, Ag-specific T cell Ca2+ responses can be triggered by DCs bearing an average of 30 Ag–MHC complexes per cell. Formation of T–DC conjugates is Ag-independent, but in the presence of the Ag, the surface of the contact zone increases and so does the amplitude of the T cell Ca2+ responses. These results suggest that Ag is better recognized by T cells on DCs essentially because T–DC adhesion precedes Ag recognition, whereas T–B adhesion requires Ag recognition. Surprisingly, we also recorded small Ca2+ responses in T cells interacting with unpulsed DCs. Using DCs purified from MHC class II knockout mice, we provide evidence that this signal is mostly due to MHC–TCR interactions. Such an Ag-independent, MHC-triggered calcium response could be a survival signal that DCs but not B cells are able to deliver to naive T cells.
South London trust losing 1m a week should be broken up, says administrator
Authors: N. Hawkes
Journal: BMJ (2012)

The debt ridden trust that provides hospital services in southeast London should be broken up and its parts taken over by other trusts, the special administrator appointed to the trust, Matthew Kershaw, has recommended in a draft report.1

He said that South London Healthcare NHS Trust, which comprises Queen Mary’s Hospital in Sidcup, Princess Royal University Hospital near Orpington, and Queen Elizabeth Hospital in Woolwich, could not resolve its financial problems and that the best hope of creating a stable platform for the future was to break it up. 

The trust, formed in 2009, inherited debts that have since risen to a total of £153m (€190m; $245m). It is running a deficit of more than £1m a week, …
The Autopsy as Research
Authors: Joseph F. A. McManus
Journal: JAMA (1965)

Each autopsy is potentially a research procedure. Customarily we think of Research—with a capital R—as something performed by a group of scientists (frequently described as "dedicated") who engage in experimental interventions and usually alter some aspect of a group of animals, and who utilize the fantastic and photogenic gadgetry of modern biomedical science. In such surroundings new facts and new relationships have emerged. In the definition of research<i>new</i>is the operational element: research develops<i>new</i>knowledge,<i>new</i>relationships,<i>new</i>considerations. Library study is research if new knowledge is gained; so is the usual animal experimentation under appropriate circumstances; so is the autopsy because the prosector, examining the organs and tissues of the deceased, is developing new knowledge about the case under study. Considering the autopsy as essentially a research procedure, we must ask whether the present day autopsy utilizes appropriate and contemporary techniques. Admittedly there is a very great
Ankylosing spondylitis and epidemic Reiter's syndrome: genetics and environment [Proceedings].
Authors: A Calin, J F Fries
Journal: Annals of the Rheumatic Diseases (1976)

From the study of our cases we think that the process does not seem to be a coincidence of both diseases but rather of the action of the X factor or factors of RA upon the domain of AS which would result in a variant of associate AS.This would be the true 'rheumatoid spondyloarthritis'.Its rate of frequency, since the predominance of AS marked by HL-A 27 is 6% in our country, would be somewhat higher than that reported by Fallet, if our hypothesis proves to be correct.Evi- dently it would not reach the ratio of 1/1600 which is the ratio to be expected if every factor of RA, by incidence of the HL-A 27, would cause this mixed picture.
Ventricular function before and after direct revascularization surgery. A proposal for an index of vascularization to correlate angiographic and ventriculographic findings.
Authors: J A Levine, D J Bechtel, P F Cohn, M V Herman, R Gorlin, L H Cohn, J J Collins
Journal: Circulation (1975)

In order to determine the effect of direct bypass surgery on the total coronary arterial supply to the heart, a numerical construct was devised to incorporate the development of new obstructive lesions and the presence of patent or nonpatent grafts. This construct, termed a vascularization index (VI), was used to evaluate left ventricular function and anginal symptoms after coronary artery bypass surgery in 56 patients. Patients with an increase in local or total arterial blood supply (positive delts VI) often had similar directional changes in segmental wall motion and ventricular ejection fraction. Patients with a decrease in local or total arterial blood supply (negative delta VI), due to either nonpatent grafts or progression of atherosclerotic disease, also usually had similar directional changes in segmental wall motion and ventricular ejection fraction. (Although nearly all patients reported a decrease in anginal symptoms after surgery, delta VI could not identify degree of improvement.) Use of an integrated approach in describing pre and postoperative myocardial blood supply appears to be the most reliable method of explaining changes in left ventricular function.
San Francisco's HIV infection rate doubles
Authors: G. Yamey
Journal: BMJ (2001)

The annual rate of new HIV infections in men who have sex with men in San Francisco has doubled over the past four years, from 1.04% in 1997 to 2.2% in 2001.

This rise has alarmed epidemiologists because the incidence of HIV infection in the city's gay community had been stable from 1992 to 1996. Willi McFarland, chief of the San Francisco seroepidemiology unit, told the BMJ : “The weight of evidence now …