Normocalcemia in a Hypoparathyroid Patient with Sarcoidosis: Evidence for Parathyroid-Hormone-Independent Synthesis of 1,25 Dihydroxyvitamin D
Authors: JOSEPH ZIMMERMAN
Journal: Annals of Internal Medicine (1983)

Brief Reports1 March 1983Normocalcemia in a Hypoparathyroid Patient with Sarcoidosis: Evidence for Parathyroid-Hormone-Independent Synthesis of 1,25 Dihydroxyvitamin DJOSEPH ZIMMERMAN, M.D., MICHAEL F. HOLICK, Ph.D., M.D., JUSTIN SILVER, M.D., Ph.D.JOSEPH ZIMMERMAN, M.D.Search for more papers by this author, MICHAEL F. HOLICK, Ph.D., M.D.Search for more papers by this author, JUSTIN SILVER, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-338 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSarcoidosis may lead to hypercalcemia due to the increased levels of serum 1,25 dihydroxyvitamin D (1,25(OH)2D) (1). This biologically active metabolite of vitamin D is produced by 1 α hydroxylation of 25 hydroxy vitamin D in the kidneys (2), a reaction normally stimulated by parathyroid hormone (PTH). A patient with postoperative hypoparathyroidism developed sarcoidosis and an elevated serum 1,25(OH)2D level, resulting in a prolonged remission of hypocalcemia.A 49-year old woman was hospitalized in May 1978 because of fever and precordial pain. The patient had had a subtotal thyroidectomy in 1953 for a diffuse, nontoxic goiter. She later developed tetany,...References1. BELLSTERNPANTZERSINHADELUCA NPETH. Evidence that increased circulating 1α,25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J Clin Invest. 1979;64:218-25. CrossrefMedlineGoogle Scholar2. FRASERKODICEK DE. Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature. 1970;228:764-6. CrossrefMedlineGoogle Scholar3. WEISMANREITERROOT YEA. Measurement of 24,25 dihydroxyvitamin D in sera of neonates and children. J Pediatr. 1977;91:904-8. CrossrefMedlineGoogle Scholar4. EISMANHAMSTRAKREAMDELUCA JABH. A sensitive, precise and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma. Arch Biochem Biophys. 1976;176:235-43. CrossrefMedlineGoogle Scholar5. BRANDT K. Een patient met idiopathische hypoparathyreoidie tevens lijdende aan sarcoidosis. Ned Tijdschr Geneeskd. 1964;108:11-51, 2456-61. Google Scholar6. JOACHIM G. Temporary amelioration of primary idiopathic hypoparathyroidism by a noncaseating granulomatous disease. N Engl J Med. 1964;271:75-9. CrossrefMedlineGoogle Scholar7. STERNDE OLAZABALBELL PJN. Evidence for abnormal regulation of circulatory 1α,25-dihydroxyvitamin D in patients with sarcoidosis and normal calcium metabolism. J Clin In vest. 1980;66:852-5. CrossrefMedlineGoogle Scholar8. HAUSSLERMCCAIN MT. Basic and clinical concepts related to vitamin D metabolism and action. N Engl J Med. 1977;297:974-83. CrossrefMedlineGoogle Scholar9. CUSHARDSIMONCANTERBURYREISS WAJE. Parathyroid function in sarcoidosis. N Engl J Med. 1972;286:395-8. CrossrefMedlineGoogle Scholar10. BARBOURCOBURNSLATOPOLSYNORMANHORST GJEAR. Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25 dihydroxyvitamin D. N Engl J Med. 1981;305:440-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hadassah University Hospital Jerusalem, Israel Massachusetts General Hospital Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIncreased brain vitamin D receptor expression and decreased expression of cathelicidin antimicrobial peptide in individuals who died by suicideA Rare Case of Hypercalcemic Sarcoidosis in a Patient With 50 Years of Stable HypoparathyroidismHypercalcemia in granulomatous disorders: a clinical reviewHypoparathyroidism and sarcoidosisPrimary HyperparathyroidismHypercalcemia in a Patient With Hypoparathyroidism and Nocardia asteroides Infection: A Novel ObservationVitamin D, Calcium, and SarcoidosisCalcium and vitamin D metabolism in granulomatous diseasesHypercalcemia and vitamin d metabolism in Hodgkin's disease. Is there an underlying immunoregulatory relationship?The Role of the Vitamin D Endocrine System in Health and DiseaseVitamin D and the kidneyHydroxychloroquine treatment of hypercalcemia in a patient with sarcoidosis undergoing hemodialysisDifferent Mechanisms of Hypercalciuria in Sarcoidosis.Hypercalcemia in disseminated histoplasmosis. Aggravation by Vitamin DSarcoid granulomas metabolize 25-hydroxyvitamin D3invitroHypercalcemia Associated with Increased Serum Calcitriol Levels in Three Patients with LymphomaNEIL A. BRESLAU, M.D., JAMES L. McGUIRE, M.D., JOSEPH E. ZERWEKH, Ph.D., EUGENE P. FRENKEL, M.D., CHARLES Y. C. PAK, M.D.Vitamin D Conversion by Sarcoid Lymph Node HomogenateREBECCA S. MASON, M.B., Ph.D., THERESA FRANKEL, B.V.Sc., Ph.D., YUK-LUEN CHAN, M.B., DIANNE LISSNER, SOLOMON POSEN, M.D. 1 March 1983Volume 98, Issue 3Page: 338-338KeywordsHypercalcemiaHypocalcemiaHypoparathyroidismKidneysMetabolitesNephrologyParathyroid hormoneSarcoidosisThyroidectomyVitamin D Issue Published: 1 March 1983 PDF DownloadLoading ...