tbuckley/cabot-search huggingface dataset:
Infarction Patterns in Endocardial Fibroelastosis
Authors: JOHN P. LINTERMANS, EDWARD L. KAPLAN, BEVERLY C. MORGAN, DAVID BAUM, WARREN G. GUNTHEROTH
Journal: Circulation (1966)

Three cases of endocardial fibroelastosis with vectorcardiographic findings suggestive of an anterior myocardial infarct are presented. It had been previously reported that such vectorcardiographic features were diagnostic of anomalous origin of the left coronary artery. We conclude that the two diseases cannot be differentiated on the basis of electrocardiography or vectorcardiography alone. Two of the cases presented were in identical twins; serial scalar electrocardiograms and vectorcardiograms were obtained during the development and progression of endocardial fibroelastosis.
AN ANALYTIC STUDY OF UREMIA.WITH SOME GENERAL CONCLUSIONS IN REGARD TO ITS CAUSES AND TREATMENT.
Authors: ALFRED C. CROFTAN
Journal: JAMA (1906)

<h3>CRITIQUE OF CURRENT UREMIA THEORIES.</h3> If the current belief that uremia is due to renal inadequacy and the retention in the blood and tissues of excrementitious urinary bodies were correct, then (1) complete anuria should always produce uremia, and (2) the blood of uremic patients should always show an increase and the urine a corresponding decrease of urinary substances. <h3>Anuria Without Uremia.</h3> —Many cases of complete anuria, due to various causes, are, however, recorded, in some instances persisting for several weeks, in which none of the characteristic phenomena of uremia developed. Most of these patients for days complained of nothing more than a feeling of extreme lassitude, death resulting suddenly from heart failure without preceding coma or amaurosis, and without eclamptic spasms or typic changes of the blood pressure. On the other hand, uremia not infrequently occurs when the flow of urine is abundant and the excretion of urinary solids
The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
Authors: Kirsten Neubert, Silke Meister, Katrin Moser, Florian Weisel, Damian Maseda, Kerstin Amann, Carsten Wiethe, Thomas H Winkler, Joachim R Kalden, Rudolf A Manz, Reinhard E Voll
Journal: Nature Medicine (2008)
Hepatitis C Infection and Type 2 Diabetes in American-Indian Women
Authors: Charlton Wilson
Journal: Diabetes Care (2004)

The aim of this study was to describe the association between hepatitis C virus (HCV) infection and type 2 diabetes among a group of American-Indian women who were screened for both conditions.The study population was a convenience sample of women who were receiving prenatal care. All women were systematically screened for both HCV and diabetes.A total of 426 women were included in the sample. HCV infection was detected in 13 (3.1% [95% CI 1.7-5.0]) and type 2 diabetes in 22 (5.2%, [3.3-7.6]) women. Women diagnosed with type 2 diabetes were more obese and had higher serum alanine aminotransferase activity compared with women without diabetes. Four of 13 (30.8% [10.6-58.7]) HCV-infected women and 18 of 413 (4.4% [2.7-6.7]) women without evidence of HCV infection had type 2 diabetes. (odds ratio 9.8 [95% CI 2.4-34.0], Fisher's exact test P = 0.003). In a logistic regression model, increasing age (10-year increments), obesity (by standard deviations from the mean BMI), and positive HCV status were each independently related to the diagnosis of diabetes.Among American-Indian women, type 2 diabetes is more common in those with than in those without HCV infection. This association and its potential mechanisms may have clinical implications. Investigation into the mechanisms linking HCV infection to the expression of type 2 diabetes may also help to define processes that promote the development of type 2 diabetes in susceptible individuals.
Abstract 3943: Affymetrix whole genome microarray analysis of 51 human tumor cell lines representative of 16 different tissues of origin: Unsupervised hierarchical clustering
Authors: Michael J. Roberts, Michael S. Koratich, Richard D. May, William R. Waud, Murray Stackhouse, Andrew D. Penman, Meredith S. Plaxco, Tommie A. Gamble, Kristy L. Berry, Robert J. Rooney, Yulia Y. Maxuitenko
Journal: Cancer Research (2011)

Abstract The total mRNA for each sample of 51 human tumor cell lines representative of 16 different tissues of origin was split into 3 replicates, and analyzed against the entire human genome using standard Affx WT procedures. Approximately 50% of the samples (25 out of the 51 cell lines tested) exhibited low-level clustering related to their tissue of origin. The remaining 50% (26 out of the 51 cell lines tested) did not cluster with other samples of the same tissue of origin. These data reveal the importance of testing potential anticancer agents in multiple models representative of several different tumors of origin, as there is a 50% chance that the model chosen is not actually representative of the intended tissue of origin. This analysis also showed that the pancreatic cancer cell line CFPAC-1 did not cluster with any other cell line tested, revealing the unique genetic profile of this cell line. Interestingly, the reported lung cancer cell lines NCI-H69 and NCI-H82 clustered more closely with leukemic lines than with lung or any other solid tumor. This is particularly interesting as these lines are known to grow/behave more like a suspension culture than a monolayer. The NCI recently published its genetic analysis of their 60-panel, and they revealed that the MDA-MB-435 cell line, traditionally thought to be a breast cancer cell line, more closely resembled a melanoma line; hence, it was re-classified as a melanoma (likely a metastasized melanoma that was taken from the breast site). Our analysis reveals that another traditional breast cancer cell line, UISO-BCA-1, also clusters more closely with the melanomas (including the MDA-MB-435 cell line), suggesting that this cell line also may have been misclassified. Based on these data, we suggest that any potential anticancer agent showing activity in a particular cell line should be tested in other cell lines that cluster with the active line, and not merely in other lines supposedly representative of the same tissue of origin. Furthermore, in early stage testing, it would be more prudent to test several cell lines from different clusters, rather than several cell lines from different tissues of origin. It follows that by testing orphan drugs against several cell lines from each cluster, it would be possible to significantly narrow (and possibly identify), the likely drug target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3943. doi:10.1158/1538-7445.AM2011-3943
What's Going on in Oregon?
Authors: David M. Eddy
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of complete remission of advanced stage mycosis fungoides by allogeneic hematopoietic stem cell transplantation
Authors: Nehal Masood, Kenneth J. Russell, John E. Olerud, Daniel E. Sabath, George E. Sale, Kristine C. Doney, Mary E.D. Flowers, Alexander Fefer, John A. Thompson
Journal: Journal of the American Academy of Dermatology (2002)
Don't use antipsychotics routinely to treat agitation and aggression in people with dementia
Authors: A. Corbett, A. Burns, C. Ballard
Journal: BMJ (2014)

#### The bottom line

Behavioural and psychological symptoms of dementia such as agitation and aggression are commonly treated with atypical antipsychotic drugs, which are associated with severe side effects.1 However, there is increasing evidence of potential harms associated with use of these drugs in people with dementia, and guidelines increasingly recommend restricting their use. In Europe, only risperidone is currently licensed for use in dementia and only for up to six weeks in patients with severe aggression, defined as causing risk or severe distress, which has not responded to other treatments. No antipsychotics are approved for this patient group in the United States. Best practice guidelines, including National Institute for Health and Care Excellence guidelines in the United Kingdom and American Psychiatric Association guidelines in the US, are similar. However, they do not distinguish between individual atypical antipsychotics and recommend a maximum treatment period of 12 weeks, except in exceptional circumstances.2 3

#### Sources and selection criteria

This article is based on an updated review of the literature published in systematic reviews. We searched the electronic databases PubMed, Embase, and the Cochrane Library. We evaluated individual randomised controlled trials from systematic reviews to calculate the specific attributable risk of key adverse events associated with risperidone in people with Alzheimer’s disease. Studies were selected according to the …
Uterine devices and pelvic inflammatory disease
Authors: Elton Kessel, StephenP. Higgins, RichardN. Shen, JamesS. Bingham, CarolineS. Bradbeer, TimothyM.M. Farley, Olav Meirik, PatrickJ. Rowe, MichaelJ. Rosenberg, Jian-Hua Chen
Journal: The Lancet (1992)
ARSPHENAMIN (SALVARSAN) REACTIONS
Authors: H. S. Warren
Journal: JAMA (1918)

<h3>To the Editor:</h3> —Many have gained the impression that arsphenamin is a severely toxic spirocheticide. I believe that none of the American preparations are as toxic as was the German-made salvarsan. Many physicians have used the American products in our laboratories, and have found the reactions fewer and lighter than were formerly noticed with the German-made salvarsan. These deductions are made from several thousand treatments with the German salvarsan and the American-made salvarsan and arsenobenzol. An unfortunate feature is that many physicians have substituted other forms of antisyphilitic treatment, with the result that the patients do not have such an efficient destruction of spirochetes as they did with the use of salvarsan. When a death or severe reaction follows the use of one of these drugs, it is reported both in the public and in the medical press, but very little is said of the thousands of favorable results. Occasionally
202 A CASE CONTROL STUDY OF IMPACT: A BRIEF AND EFFECTIVE WEB-BASED NEUROPSYCHOLOGICAL ASSESSMENT BATTERY TO DIAGNOSE MINIMAL HEPATIC ENCEPHALOPATHY (MHE)
Authors: M. Tsushima, W. Tsushima, V. Tsushima, N. Lim, E. Madrigal, C. Jackson, M. Mendler
Journal: Journal of Hepatology (2010)
Abstract 3119: Phosphorylation of epidermal growth factor receptor at Ser1046/1047 by p38 mitogen-activated protein kinase plays a critical role in its downregulation in cancer cells
Authors: Seiji Adachi, Masanori Nakashima, Takahiro Yamauchi, Yohei Shirakami, Masahito Shimizu, Ichiro Yasuda, Hisataka Moriwaki, Osamu Kozawa
Journal: Cancer Research (2010)

Abstract The mechanism underlying downregulation of EGF receptor (EGFR) is important for the regulation of cancer cells. Although the phosphorylation of EGFR at Tyr1045 and Ser1046/1047 reportedly account for its downregulation, the exact mechanism remains unclear. We recently reported that p38 mitogen-activated protein kinase (MAPK), a stress-inducible kinase believed to negatively regulate tumorigenesis, controls EGFR downregulation via its phosphorylation at Ser1046/1047 (Cancer Lett 2009;277:108-13). To further investigate the role of phosphorylation of p38 MAPK in the action of anti-cancer drug, we examined the effects of (−)-epigallocatechin gallate (EGCG) and several HSP90 inhibitors (17-AAG, geldanamycin and 17-DMAG) on p38 MAPK in colon and pancreatic cancer cells. While EGCG and HSP90 inhibitors caused downregulation of EGFR and subsequent cell death, they induced phosphorylation of p38 MAPK, and inhibition of p38 MAPK suppressed the internalization and subsequent degradation of EGFR. Moreover, we found that they caused phosphorylation of EGFR at Ser1046/1047, not Tyr1045, and that they were also suppressed by the inhibition of p38 MAPK. Taken together, our results strongly suggest that phosphorylation of EGFR at Ser 1046/1047 via activation of p38 MAPK plays a pivotal role in anti-cancer drug-induced downregulation of EGFR. These findings may indicate new therapeutic strategies for inhibiting the proliferation of human cancers that are highly dependent on the activation of EGFR. (Adachi S et al., Carcinogenesis 2009;30:1544-52) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3119.
Prevalence of antibody to human T lymphotropic virus type III by risk group and area, United Kingdom 1978-84.
Authors: P P Mortimer, W J Jesson, E M Vandervelde, M S Pereira
Journal: BMJ (1985)

Antibody to human T lymphotropic virus type III (anti-HTLV-III) was sought in 2150 patients in three groups at risk with a radioimmunoassay and an immunofluorescence test. Results by the two methods were closely concordant. Anti-HTLV-III was already present in some British homosexuals in 1980 and in some British haemophiliacs in 1981, and since then its prevalence has increased. Of homosexual patients needing laboratory tests for hepatitis B virus infection in 1984, 34% of 282 in London and 5% of 955 in five centres outside London were positive for anti-HTLV-III. Of haemophiliacs sampled in 1984, 38% of 81 were anti-HTLV-III positive. Most of the seropositive haemophiliacs were regular recipients of commercial factor VIII concentrates. Few British intravenous drug abusers sampled in 1984 (2.5% of 203) were positive for anti-HTLV-III. These results show that infection with HTLV-III has rapidly become widespread among homosexuals attending sexually transmitted disease clinics and among haemophiliacs receiving pooled blood products. Thus, while many anti-HTLV-III positive individuals may remain asymptomatic, there may soon be a considerable increase in the incidence of the acquired immune deficiency syndrome and related disease in Britain.
Prospective validation of the endurance shuttle walking test in the context of bronchodilation in COPD
Authors: Benoit Borel, Véronique Pepin, Donald A. Mahler, Éric Nadreau, François Maltais
Journal: European Respiratory Journal (2014)

This study focused on repeatability data and minimal important difference (MID) estimates of the endurance shuttle walking test (ESWT). 255 chronic obstructive pulmonary disease patients (forced expiratory volume in 1 s 54.7±13.2% predicted) completed four ESWTs at different times during the 8-week study: two under baseline conditions with tiotropium (1 week apart), one after a single dose and one after 4 weeks of either fluticasone propionate/salmeterol combination or placebo in addition to tiotropium. 97 patients performed all the tests with a portable metabolic system. Reproducibility of test performance and cardiorespiratory response was investigated with the data obtained on the first two ESWTs. The mean differences between the first two ESWT performances (-6.7±72.2 s and -7.3±113.1 m for endurance time and walking distance, respectively) were not statistically significant. The between-test end-exercise and isotime values for each cardiorespiratory parameter were not significantly different from each other. With the exception of arterial oxygen saturation by pulse oximetry, the repeatability of cardiorespiratory adaptations to ESWT was also confirmed with strong Pearson and intraclass correlation coefficients. Finally, changes of 56–61 s and 70–82 m in endurance time and distance walked, respectively, were perceived by patients. This study provides methodological information supporting the reliability of the ESWT and suggests MID estimates for this test.
P414 ASSESSMENT OF THE CHANGE IN ESTIMATED GLOMERULAR FILTRATION RATES IN TELBIVUDINE- OR LAMIVUDINE-BASED TRERAPY IN PATIENTS WITH CHRONIC HEPATITIS B
Authors: J. Sun, J. Cheng, X. Chen, Q. Xie, D. Tan, H. Wang, S. Chen, Y. Yu, H. Tang, J. Niu, J. Sheng, Y. Sun, Q. Ning, M. Wan, X. Bai, G. Shi, H. Ren, M. Xu, X. Dou, J. Shi, J. Jiang, X. Chen, H. Long, M. Wang, H. Zhang, Z. Gao, C. Chen, J. Jiang, H. Ma, J. Jia, J. Hou
Journal: Journal of Hepatology (2014)
Gastroparesis Secondary to a Medulloblastoma of the Posterior Fossa
Authors: A SZILAGYI, J STERN, S ARMANIOUS, S BREM
Journal: Clinical Nuclear Medicine (1987)

A patient with a 4-month history of unexplained nausea and vomiting is reported. The only abnormality found initially was severe gastroparesis found by gastric emptying scan. Subsequently, a posterior fossa tumor was found. The pathogenesis of this unusual presentation and the role of the gastric emptying scan is discussed.
Oncogenic Activation of Pak1-Dependent Pathway of Macropinocytosis Determines BCG Entry into Bladder Cancer Cells
Authors: Gil Redelman-Sidi, Gopa Iyer, David B. Solit, Michael S. Glickman
Journal: Cancer Research (2013)

Abstract Bacille Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis that is used widely as a vaccine for tuberculosis and is used as an effective treatment for superficial bladder carcinoma. Despite being the most successful cancer biotherapy, its mechanism of action and response determinants remain obscure. Here, we establish a model system to analyze BCG interaction with bladder cancer cells, using it to show that these cells vary dramatically in their susceptibility to BCG infection. Unexpectedly, the uptake of BCG by bladder cancer cells occurs by macropinocytosis rather than phagocytosis. BCG entry into bladder cancer cells relied upon Rac1, Cdc42, and their effector kinase Pak1. The difference in susceptibility between BCG-permissive and -resistant bladder cancer cells was due to oncogenic activation of signaling pathways that activate macropinocytosis, with phosphoinositide 3-kinase inhibitor activation stimulating BCG uptake independently of Akt. Similarly, activated Ras strongly activated Pak1-dependent uptake of BCG. These results reveal that oncogenic activation of macropinocytosis determines BCG uptake by bladder cancer cells, implying that tumor responsiveness to BCG may be governed by the specific mutations present in the treated cancer cell. Cancer Res; 73(3); 1156–67. ©2013 AACR.
Five-Year Optical Coherence Tomography Follow-Up of an Everolimus-Eluting Bioresorbable Vascular Scaffold
Authors: Antonios Karanasos, Cihan Simsek, Patrick Serruys, Jurgen Ligthart, Karen Witberg, Robert-Jan van Geuns, George Sianos, Felix Zijlstra, Evelyn Regar
Journal: Circulation (2012)
Screening for Renovascular Hypertension-Reply
Authors: Robert J. Havey
Journal: JAMA (1986)

<h3>In Reply.—</h3> We agree with Drs Bush and Kidd that<i>bilateral</i>renal artery stenoses are found in approximately 25% of all cases of renovascular hypertension. The largest published series of patients, the Cooperative Study of Renovascular Hypertension, found bilateral renovascular disease in 28% (250 patients) of their patients with renal artery stenosis.<sup>1</sup>However, many renal artery lesions are functionally insignificant, since unilateral repair often cures or improves hypertension in patients with bilateral stenoses. For example, Schwarten et al<sup>2</sup>noted that while 14 of their patients had bilateral renal artery stenosis, nine of these patients responded to only unilateral angioplasty. Furthermore, the Cooperative Study of Renovascular Hypertension noted that in patients with bilateral disease who responded to surgery, 83.3% had abnormal rapid-sequence IVPs. Thus, while the sensitivity of the rapid-sequence IVP is lower in detecting bilateral renal artery stenosis, it remains a useful means of uncovering functionally significant renal vascular
P56. A novel cancer vaccine with nanogel-based antigen transporter and sequence-optimised long peptide antigen
Authors: N Harada, D Muraoka, T Hayashi, F Momose, H Shiku, Y Tahara, S Sawada, K Akiyoshi
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts The limited success of cancer vaccines in clinical could be owing to their low efficacy that can be largely affected by their formulation. Vaccine formulation usually consists of three components, antigen, delivery system, and adjuvant. Recently, long peptide antigen (LPA) has
Long-term bodyweight and glucose management effects of the Microclinic Social Network Health Behavioral Program in Amman, Jordan: 2-year results
Authors: Daniel E Zoughbie, Kathleen T Watson, Nancy Bui, Rami S Farraj, Marta R Prescott, Eric L Ding
Journal: The Lancet Global Health (2014)

BackgroundEvidence shows that social network phenomena are major drivers of lifestyle risk factors that contribute to risks of obesity and diabetes. Since 2005, Microclinic International has pioneered the research and development of a novel social network "microclinic" model—a social network programme designed to propagate lifestyle change and leverage pre-existing social networks to improve health. We sought to assess the effectiveness of such a social network programme for sustaining long-term health.MethodsWith the Microclinic Social Network Behavioral Health Program in Jordan, patients with diabetes or prediabetes were enrolled in the 4-month Microclinic International programme, with data collection at baseline, the end of the 4-month programme, 12 months, and 24 months after baseline (between March, 2010, and April, 2012). Social clusters of two to eight individuals participated together in a programme with weekly physical activity, nutrition, health education, and social activity sessions. Multi-level repeated measures regression estimated the long-term change in weight, body-mass index (BMI), and HbA1c during programme and follow-up.FindingsOf 315 participants with a full 2-years of follow-up, 262 (83·2%) completed the 4-month programme, 283 (89·8%) returned for the 12-month follow-up, and 216 (69·6%) for the 24-month follow-up. At completion of the 4-month programme, participants lost an average of 2·89 kg (−3·84 to −1·93; p<0·0001). At 1 year, participants, on average, sustained a weight reduction of −1·84 kg (−2·77 to −0·91; p<0·0001) from baseline, a −0·69 (−1·03 to −0·36) reduction in BMI, and −0·46% (−0·60 to −0·32; p<0·0001) sustained absolute reduction in HbA1c. 2 years from baseline, participants maintained an average weight loss of −1·60 kg (−2·67 to −0·54; p=0·003) from baseline, −0·43 (−0·82 to −0·05) reduction in BMI, and −0·97% (−1·12 to −0·81; p<0·0001) reduction in HbA1c.InterpretationOur results show that the Microclinic Social Network Behavioral Health Program was translated well into this cultural context and participants had long-term sustained benefits in bodyweight, BMI, and glucose control.FundingBRIDGES.