Very Late Restenosis after Paclitaxel-Eluting Stent Implantation
Authors: John Cosgrave, Asif Qasim, Azeem Latib, Tiziana Claudia Aranzulla, Antonio Colombo
Journal: Annals of Internal Medicine (2007)

Letters18 December 2007Very Late Restenosis after Paclitaxel-Eluting Stent ImplantationJohn Cosgrave, MD, Asif Qasim, PhD, Azeem Latib, MD, Tiziana Claudia Aranzulla, MD, and Antonio Colombo, MDJohn Cosgrave, MDFrom Centro Cuore Columbus and San Raffaele Scientific Institute, Milan, Italy.Search for more papers by this author, Asif Qasim, PhDFrom Centro Cuore Columbus and San Raffaele Scientific Institute, Milan, Italy.Search for more papers by this author, Azeem Latib, MDFrom Centro Cuore Columbus and San Raffaele Scientific Institute, Milan, Italy.Search for more papers by this author, Tiziana Claudia Aranzulla, MDFrom Centro Cuore Columbus and San Raffaele Scientific Institute, Milan, Italy.Search for more papers by this author, and Antonio Colombo, MDFrom Centro Cuore Columbus and San Raffaele Scientific Institute, Milan, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-12-200712180-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Late restenosis after drug-eluting stent implantation has been described for sirolimus-eluting stents (Cypher, Johnson & Johnson, Warren, New Jersey) (1–3) but not for paclitaxel-eluting stents (Taxus, Boston Scientific, Natick, Massachusetts) (4).Objective: To describe a patient with a paclitaxel-eluting stent who presented with late in-stent restenosis 33 months after stent placement.Case Report: A 76-year-old man with a history of an inferior myocardial infarction and coronary artery bypass grafting in 1989 presented to our center in April 2004 with stable angina pectoris. In 2001, he underwent bare-metal stent implantation in the saphenous vein graft to the right coronary artery, ...References1. Wessely R, Kastrati A, Schömig A. Late restenosis in patients receiving a polymer-coated sirolimus-eluting stent [Letter]. Ann Intern Med. 2005;143:392-4. [PMID: 16106033] LinkGoogle Scholar2. O'Hanlon R, Foley D. Late DES restenosis 36 months post PCI of LAD. A case report. EuroIntervention. November 2006. Accessed at www.europcronline.com/eurointervention/7th_issue on 18 October 2007. Google Scholar3. Cosgrave J, Corbett SJ, Melzi G, Babic R, Biondi-Zoccai GG, Airoldi F, et al. Late restenosis following sirolimus-eluting stent implantation. Am J Cardiol. 2007;100:41-4. [PMID: 17599438] CrossrefMedlineGoogle Scholar4. Hermiller JB, Ellis SG, Cox DA, O'Shaughnessy CD, Mann T, Turco M, et al. Four year clinical outcomes of the polymer-based paclitaxel-eluting TAXUS stent: the TAXUS IV trial [Abstract]. Presented at the Scientific Sessions of the Transcatheter Cardiovascular Therapeutics, Washington, DC, 22-27 October 2006. Am J Cardiol. 2006;98:27M. Google Scholar5. Farb A, Heller PF, Shroff S, Cheng L, Kolodgie FD, Carter AJ, et al. Pathological analysis of local delivery of paclitaxel via a polymer-coated stent. Circulation. 2001;104:473-9. [PMID: 11468212] CrossrefMedlineGoogle Scholar6. Virmani R, Liistro F, Stankovic G, Di Mario C, Montorfano M, Farb A, et al. Mechanism of late in-stent restenosis after implantation of a paclitaxel derivate-eluting polymer stent system in humans. Circulation. 2002;106:2649-51. [PMID: 12438288] CrossrefMedlineGoogle Scholar7. Virmani R, Guagliumi G, Farb A, Musumeci G, Grieco N, Motta T, et al. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation. 2004;109:701-5. [PMID: 14744976] CrossrefMedlineGoogle Scholar8. Hasegawa K, Tamai H, Kyo E, Kosuga K, Ikeguchi S, Hata T, et al. Histopathological findings of new in-stent lesions developed beyond five years. Catheter Cardiovasc Interv. 2006;68:554-8. [PMID: 16969849] CrossrefMedlineGoogle Scholar9. Brenner DJ, Miller RC. Long-term efficacy of intracoronary irradiation in inhibiting in-stent restenosis. Circulation. 2001;103:1330-2. [PMID: 11238281] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: John Cosgrave, MD; Asif Qasim, PhD; Azeem Latib, MD; Tiziana Claudia Aranzulla, MD; Antonio Colombo, MDAffiliations: From Centro Cuore Columbus and San Raffaele Scientific Institute, Milan, Italy.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLate Restenosis in Patients Receiving a Polymer-Coated Sirolimus-Eluting Stent Rainer Wessely , Adnan Kastrati , and Albert Schömig Metrics Cited byBiodegradable paclitaxel-loaded microparticles prepared from novel block copolymers: influence of polymer composition on drug encapsulation and releaseSerial angiographic and intravascular ultrasound evaluation to interrogate the presence of late “catch-up” phenomenon after cypher® sirolimus-eluting stent implantationNovolimus™-eluting coronary stent systemReestenosis muy tardía de un stent farmacoactivo recubierto de paclitaxel empleado como tratamiento de una previa reestenosis intra-stent de un stent convencionalVery Late Restenosis of a Paclitaxel-Eluting Stent Implanted to Treat Previous in-Stent Restenosis of a Bare Metal StentIncidence and Predictors of Very Late (≥4 Years) Major Cardiac Adverse Events in the DESIRE (Drug-Eluting Stents in the Real World)-Late Registry 18 December 2007Volume 147, Issue 12Page: 885-887KeywordsAnginaAngiographyDrugsMyocardial infarctionPericardiumRight coronary arteryStable coronary artery diseaseStent implantationUltrasound imagingVeins ePublished: 18 December 2007 Issue Published: 18 December 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. 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