tbuckley/cabot-search huggingface dataset:
Data on flu deaths are potentially misleading, say researchers
Authors: Z. Kmietowicz
Journal: BMJ (2009)

The only thing that can definitely be said about the A/H1N1 flu outbreak is that the virus is not becoming more virulent, said epidemiologists this week. 

To get an accurate idea of the death rate from the current pandemic studies need to be carried out that combine a community sample, to monitor the extent of mild disease, together with a hospital survey to determine numbers of more severe cases and deaths, they say in a paper in the BMJ (2009;339:b2840, doi:10.1136/bmj.b2840).

Azra Ghani, professor …
The European Respiratory Society fellowship programme: supporting young careers and building networks
Authors: Robert Bals, Josephine Ricou Yanmaz, Céline Schaffter, Carine Pannetier, Nadia Kamel, Roelinde Middelveld, Sven-Erik Dahlén, Bart N. Lambrecht, Benoit Nemery, Laurent Nicod, Stephen Holgate
Journal: European Respiratory Journal (2013)

The ERS fellowship scheme is one of the world's largest and most successful support programmes http://ow.ly/myOy0
VLA protein expression on epidermal cells (keratinocytes, Langerhans cells, melanocytes): a light and electron microscopic immunohistochemical study
Authors: G. ZAMBRUNO, V. MANCA, M. L. SANTANTONIO, D. SOLIGO, A. GIANNETTI
Journal: British Journal of Dermatology (1991)

The very late antigens, or VLA proteins, are a family of cell surface heterodimers (α1–6β1) that mediate cell adhesion to specific components of the extracellular matrix (collagens, fibronectin, laminin). In normal human epidermis, the common VLA β1 subunit is expressed on basal keratinocytes (BK). Langerhans cells (LC) and melanocytes. By means of light and electron microscopic immunostaining procedures, we have investigated the distribution of VLA α1,2,3,4,6 subunits on normal human adult and foetal epidermal cells, α1 antigen expression was not observed on any epidermal cell type. Both during foetal development and in adult epidermis, α2 and α3 were strongly expressed on the cell membrane of BK, while α6 was mainly expressed at their dermal pole. These different patterns of distribution suggest that the α6 subunit may mediate BK anchorage to the basement membrane zone, while the α2 and α3 subunits may also be involved in intercellular adhesion. Moreover, with immunoelectron microscopy, LC were seen to be weakly α4 and α6 positive and melanocytes were α3 and α6 positive. Thus, VLA proteins are expressed by epidermal cells in a cell-type-specific pattern that could be related to particular functional roles of these proteins.
Trauma to the Ureter: Pathogenesis and Management
Authors: Bernard R. Sears
Journal: JAMA (1965)

This, the first American book on traumatic lesions of the ureter, is of encyclopedic range. At once practical and scholarly, it will doubtless serve general surgeons, gynecologists, and urologists as the definitive text for a long time. Dr. Orkin surveys the world literature from its 19th century beginnings and delineates, point by point, the variables and ramifications of this complex subject. His detailed and precise exposition is fleshed out with many fine drawings by Stanley Waine and with reproductions of x-rays. The book comprises four major sections, the first of which deals with the anatomy and physiology of the normal and abnormal ureter, including a chapter on the processes of ureteral repair. The second and third sections discuss prevention, diagnosis, and management of the various injuries, classified according to pathogenesis. Each chapter develops fully a single topic; while this arrangement imposes a certain amount of repetitiveness, it is a great
THE OCCURRENCE OF TYPHOID BACILLI IN THE STOOLS OF TYPHOID PATIENTS,WITH A DISCUSSION OF THE PATHOGENESIS OF TYPHOID FEVER.
Authors: J. H. PRATT
Journal: JAMA (1907)

The view is generally held that the intestinal contents in typhoid fever are swarming with typhoid bacilli. The fact that many investigators have often had difficulty in isolating<i>Bacillus typhosus</i>from the stools of undoubted cases of typhoid fever has been attributed to imperfect technical methods. Some observations made by one of us seemed to indicate that the reason typhoid bacilli were not obtained from the stools during the height of the disease might be due, not to faulty bacteriologic methods, but to the fact that the typhoid micro-organisms were either absent from the feces or present in extremely small numbers. The studies here presented extend over two years. About 75 per cent. of the patients had fever at the time of the examination. All were clinically typhoid fever. In only one instance was the agglutination test persistently negative. It is probable that this was a case of infection with
CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells
Authors: Jennifer D. Bassett, Teng Chih Yang, Dannie Bernard, James B. Millar, Stephanie L. Swift, A. J. Robert McGray, Heather VanSeggelen, Jeanette E. Boudreau, Jonathan D. Finn, Robin Parsons, Carole Evelegh, Daniela Damjanovic, Natalie Grinshtein, Maziar Divangahi, Liang Zhang, Zhou Xing, Yonghong Wan, Jonathan L. Bramson
Journal: Blood (2010)
Dialogue: Can two be cheaper than one?
Authors: Sam Glucksberg
Journal: Behavioral and Brain Sciences (2004)

Pickering &amp; Garrod (P&amp;G) argue that language processing in dialogue is in principle easier than in monologue. Although dialogue situations may provide more opportunities for facilitative priming, those priming mechanisms are also available in monologue situations. In both cases, the interactive alignment model calls strict modular accounts of language processing into serious question.
Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
Authors: Janis M. Taube, Robert A. Anders, Geoffrey D. Young, Haiying Xu, Rajni Sharma, Tracee L. McMiller, Shuming Chen, Alison P. Klein, Drew M. Pardoll, Suzanne L. Topalian, Lieping Chen
Journal: Science Translational Medicine (2012)

Although many human cancers such as melanoma express tumor antigens recognized by T cells, host immune responses often fail to control tumor growth for as yet unexplained reasons. Here, we found a strong association between melanocyte expression of B7-H1 (PD-L1), an immune-inhibitory molecule, and the presence of tumor-infiltrating lymphocytes (TILs) in human melanocytic lesions: 98% of B7-H1(+) tumors were associated with TILs compared with only 28% of B7-H1(-) tumors. Indeed, B7-H1(+) melanocytes were almost always localized immediately adjacent to TILs. B7-H1/TIL colocalization was identified not only in melanomas but also in inflamed benign nevi, indicating that B7-H1 expression may represent a host response to tissue inflammation. Interferon-γ, a primary inducer of B7-H1 expression, was detected at the interface of B7-H1(+) tumors and TILs, whereas none was found in B7-H1(-) tumors. Therefore, TILs may actually trigger their own inhibition by secreting cytokines that drive tumor B7-H1 expression. Consistent with this hypothesis, overall survival of patients with B7-H1(+) metastatic melanoma was significantly prolonged compared with that of patients with B7-H1(-) metastatic melanoma. Therefore, induction of the B7-H1/PD-1 pathway may represent an adaptive immune resistance mechanism exerted by tumor cells in response to endogenous antitumor activity and may explain how melanomas escape immune destruction despite endogenous antitumor immune responses. These observations suggest that therapies that block this pathway may benefit patients with B7-H1(+) tumors.
My years with Lyme disease
Authors: C. J F Wilson
Journal: BMJ (1999)

Ifirst became unwell in the wake of some students sadly succumbing to the meningococcus. I had non-specific symptoms—malaise, fatigue—but with the photophobia, headache, and difficulty on my feet they were serious enough to warrant admission to the neurology ward for investigation. The investigations were thorough, but no cause was found.

> A label of “depression” was hung around my neck 

I was discharged back into the hands of a less than sympathetic university health service, and it was here that the mysterious spectrum of symptoms that graced my life earned me the title “malingerer,” chiselled deeply into my notes and even deeper into the clinical opinions of all those who saw me thereafter.

My aching joints were scrutinised by the rheumatologists. The neurologists put me under the inquisition again, trying to find some explanation for the interminable headache. Ultimately, as is often the case, I was directed to the psychiatrists. A label of “depression” was hung around my neck, and …
Analysis Provides Map of Protein Expression in Human Tissues
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT
Authors: Raghuveer Singh Mali, Peilin Ma, Li-Fan Zeng, Holly Martin, Baskar Ramdas, Yantao He, Emily Sims, Sarah Nabinger, Joydeep Ghosh, Namit Sharma, Veerendra Munugalavadla, Anindya Chatterjee, Shuo Li, George Sandusky, Andrew W. Craig, Kevin D. Bunting, Gen-Sheng Feng, Rebecca J. Chan, Zhong-Yin Zhang, Reuben Kapur
Journal: Blood (2012)
Comparison Between Epidermal Growth Factor Receptor (EGFR) Gene Expression in Primary Non-small Cell Lung Cancer (NSCLC) and in Fine-Needle Aspirates from Distant Metastatic Sites
Authors: Cecilia Bozzetti, Marcello Tiseo, Costanza Lagrasta, Rita Nizzoli, Annamaria Guazzi, Francesco Leonardi, Donatello Gasparro, Elena Spiritelli, Michele Rusca, Paolo Carbognani, Maria Majori, Vittorio Franciosi, Guido Rindi, Andrea Ardizzoni
Journal: Journal of Thoracic Oncology (2008)
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug
Authors: Jinsong Hu, Damian R. Handisides, Els Van Valckenborgh, Hendrik De Raeve, Eline Menu, Isabelle Vande Broek, Qian Liu, Jessica D. Sun, Ben Van Camp, Charles P. Hart, Karin Vanderkerken
Journal: Blood (2010)
Practical Considerations of the Use of Cortisone and ACTH in Rheumatoid Arthritis
Authors: R. H. Freyberg, M. Patterson, C. H. Adams, J. Durivage, C. H. Traeger
Journal: Annals of the Rheumatic Diseases (1951)

All sciences are connected; they lend each other material aid as parts of one great whole, each doing its own work not for itself alone but for the other parts, as the eye guides the whole body and the foot sustains it and leads it from place to place. As with an eye torn out or a foot cut off, so it is with the different departments of knowledge; none can attain its proper result separately, since all are parts of one and the same complete wisdom. <i>ROGER BACON (1214-1294).</i>
CLINICAL IMPACT OF BELOW–THE–ANKLE ARTERY RUN–OFF FOR THE CRITICAL LIMB ISCHEMIA
Authors: Yoshiaki Shintani, Osamu Iida, Yoshimitsu Soga, Keisuke Hirano, Daizo Kawasaki, Junichi Tazaki, Kenji Suzuki, Yusuke Miyashita, Tomohiro Kawasaki
Journal: Journal of the American College of Cardiology (2013)
Abstract 3154: Genomic landscape of metastatic colorectal cancer.
Authors: Oscar Krijgsman, Josien Haan, Beatriz Carvalho, Gerrit A. Meijer, Bauke Ylstra
Journal: Cancer Research (2013)

Abstract Background: Colorectal cancer (CRC) results from the accumulation of multiple genetic and epigenetic alterations in the genome of colorectal epithelial cells. Next to large genomic DNA copy number changes, small focal alterations can be identified, often enriched for known cancer genes. However, not all tumors present the same pattern of alterations, as CRC is a heterogeneous disease. The varying underlying biology results in different clinical outcomes, such as response to treatment. The present study aimed to document the landscape of DNA copy number changes, with special focus on focal alterations, in primary tumors of a defined subset of colorectal cancer patients who develop metastatic disease and are eligible for systemic treatment. Material and methods: Tumors were selected from mCRC patients, who participated in two Dutch multicenter phase III clinical trials, i.e. CAIRO and CAIRO2 and were treated according to three different regimens . For all patients well-defined clinical data is available. Alterations were analyzed by high-resolution array comparative genomic hybridization (aCGH), with DNA isolated from formalin-fixed paraffin-embedded (FFPE) archival blocks of 349 patients. As a reference matched normal germ-line material was used. In this way only tumor specific alterations were identified. Also, frequent copy number variations present in the general population can be distinguished from actual somatic alterations. Results: Most frequently observed large chromosomal alterations were losses of chromosomes 8p and 18 and gains of chromosomes 7, 8q 13, and 20. Seven genomic regions were significantly associated with progression free survival (PFS). The focal alterations detected are significantly enriched for cancer genes and genes frequently mutated in colorectal cancer. The gene list includes PTEN, TP53, PARK2, A2BP2 and ATBP2 located in focal losses. On focal amplifications known drugtargets such as ERBB2, EGFR and VEGF were found. Conclusion: Based on initial results we hypothesize that DNA copy number profiling may be used for therapy selection and to guide individualized anticancer therapy. Chromosomal copy number alterations in CRC have been related to response to treatment. Moreover focal alterations were enriched for cancer genes. This study was performed within the framework of CTMM, the Center for Translational Molecular Medicine Citation Format: Oscar Krijgsman, Josien Haan, Beatriz Carvalho, Gerrit A. Meijer, Bauke Ylstra. Genomic landscape of metastatic colorectal cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3154. doi:10.1158/1538-7445.AM2013-3154
A multifunctional heptamethine near-infrared dye for cancer theranosis
Authors: Shenglin Luo, Xu Tan, Qingrong Qi, Qinyuan Guo, Xinze Ran, Lilong Zhang, Erlong Zhang, Yufeng Liang, Lingling Weng, Hu Zheng, Tianmin Cheng, Yongping Su, Chunmeng Shi
Journal: Biomaterials (2012)
Mediterranean Diet and Cognitive Decline—Reply
Authors: Catherine Féart
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Pivotal Role for CXCL12 Signaling in HPV-Mediated Transformation of Keratinocytes: Clues to Understanding HPV-Pathogenesis in WHIM Syndrome
Authors: Ken Y.C. Chow, Émilie Brotin, Youcef Ben Khalifa, Laetitia Carthagena, Sébastien Teissier, Anne Danckaert, Jean-Luc Galzi, Fernando Arenzana-Seisdedos, Françoise Thierry, Françoise Bachelerie
Journal: Cell Host & Microbe (2010)
Pneumococcemia as the presenting feature of multiple myeloma
Authors: Daniel B. Costa, Byol Shin, Dennis L. Cooper
Journal: American Journal of Hematology (2004)

Abstract Multiple myeloma is associated with a susceptibility to bacterial infections, specifically for encapsulated organisms such as Streptococcus pneumoniae . However, severe bacterial infection as the initial presentation of this disease has been rarely reported. The most common presenting features are anemia, lytic lesions, hypercalcemia, and renal failure. We report two cases of pneumococcal bacteremia as the initial manifestation of an underlying multiple myeloma. The first case is of a 68‐year‐old woman with pneumococcal pneumonia and bacteremia, presenting with a white blood cell count of 900/μL and mild anemia. Further work‐up disclosed monoclonal IgG kappa and 50% plasma cells in bone marrow. Her course was complicated by acute renal failure requiring hemodialysis. The second patient is a 57‐year‐old man presenting with acute pneumococcal meningitis and bacteremia. Due to prior bacterial epiglottitis, further work‐up disclosed IgG lambda monoclonal spike and 40% plasma cells in bone marrow. Both cases responded to antibiotic therapy without complications. These two cases add to the few patients described in the literature with pneumococcemia as the first sign of multiple myeloma. Features that were common in most of these cases, and that should lead to a suspicion of myeloma in an otherwise asymptomatic patient, are S. pneumoniae bacteremia, leukopenia, mild anemia, history of prior bacterial infections, and indirect evidence of a paraproteinemia, such as increased total protein levels with low albumin. Am. J. Hematol. 77:277–281, 2004. © 2004 Wiley‐Liss, Inc.
PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts
Authors: Tomohiro Hikata, Hironari Takaishi, Jiro Takito, Akihiro Hakozaki, Mitsuru Furukawa, Shinichi Uchikawa, Tokuhiro Kimura, Yasunori Okada, Masahito Matsumoto, Akihiko Yoshimura, Riko Nishimura, Sakamuri V. Reddy, Hiroshi Asahara, Yoshiaki Toyama
Journal: Blood (2008)
A METAL SAFETY AND GLARE GOGGLE
Authors: Edward Stieren
Journal: JAMA (1942)

A safety goggle for industrial use has been designed which has the advantage over glass protective goggles in that it cannot be broken by flying particles, and vision is not interfered with by steam, perspiration or grease. It consists of two aluminum shields fitted into soft rubber with an adjustable band of the same material to hold them in place. In the center of the shield is a horizontal opening 1 mm. in width and 40 mm. long. A vertical opening of the same width and 10 mm. long bisects the horizontal opening 10 mm. from the nasal end. In addition a 20 mm. long opening is added at an axis 15 degrees off horizontal for vision in the lower field. As its crude prototype was originated by Eskimos to prevent snow blindness, the arrangement of the slots in this goggle by admitting a minimum of light reduces glare, and
Book Review The Changing Face of Medicine: Women Doctors and the Evolution of Health Care in America (The Culture and Politics of Health Care Work.) By Ann K. Boulis and Jerry A. Jacobs. 266 pp., illustrated. Ithaca, NY, ILR Press, 2008. $35. 978-0-8014-4446-3
Authors: Bonnie J. Dattel
Journal: New England Journal of Medicine (2009)
Medication requirements and house dust mite exposure in mite‐sensitive asthmatics
Authors: D. Vervloet, D. Charpin, E. Haddi, A. N'Guyen, J. Birnbaum, M. Soler, X. Van Der Brempt
Journal: Allergy (1991)

To better understand the clinical consequences of exposure to house dust mites (HDM), we investigated the relationship between treatment requirements to control symptoms in mite‐allergic asthmatic patients and HDM‐allergenic levels in their mattresses. This study included 49 asthmatic subjects recruited from an outpatient clinic. The protocol consisted of a questionnaire about the number of asthma attacks and treatment requirements in the last 3 months. Patients provided a sample of house dust collected from their mattresses by a standardized vacuum cleaning procedure. Mean antigen P1 equivalent defined as the sum of major allergens Der pI and Der fI (Ag P1 Eq) level was 1.34 μg/g dust in patients who had no treatment, 5.4 μg/g dust in patients who took puffs of beta 2 ‐agonists only when required and 17.8 μg/g dust in patients who required daily long‐term treatment. Similar relation ships were demonstrated between mean Ag P1 Eq levels and the number of asthma attacks. These data support the clinical role of allergenic exposure in HDM‐allergic asthmatics.
Review of Henri Colt, Silvia Quadrelli, and Lester Friedman, eds.,<i>The Picture of Health: Medical Ethics and the Movies</i>: Getting Familiar with the Cinema Education Methodology
Authors: Pablo González Blasco
Journal: The American Journal of Bioethics (2011)

Click to increase image sizeClick to decrease image size Notes 1. University of Oxford Press, Oxford, UK. 560 pp. Paperback. US$ 39.95.