tbuckley/cabot-search huggingface dataset:
Abstract 4588: Frequency and clinical characteristics of <i>c-MET</i> mutation in malignant melanoma
Authors: Sharon Kim, Nydia Gonzalez, Raja Luthra, Kenneth Aldape, Zhuang Zuo, Ping Liu, David Barron, Kevin B. Kim
Journal: Cancer Research (2012)

Abstract Purpose: C-MET is over-expressed in metastatic melanoma and have copy number gains at chromosome 7 in late stages of melanoma progression. However, the presence of C-MET mutation is not well known in melanoma. We analyzed tumor samples of patients with malignant melanoma to identify the frequency and the clinicopathology of C-MET mutations. Methods: We identified 103 patients with metastatic mutation who underwent testing for c-MET mutation and reviewed the clinical data of these patients. The sequencing analyses were performed by Sequenom Assay, and the mutations were confirmed with Sanger Sequencing analysis. Clinical characteristics were correlated with C-MET mutation status, and a survival analysis was performed to identify significant associations. Results Among the 103 patients, eleven (11%) patients had melanoma harboring a C-MET mutation. Five (4.5%) patients had N375S mutation; two (1.8%) patients had R988C mutation; two (1.8%) had T1010I; one (1%) patient had H1112R and another patient had N375/T1010 mutation. A median age at diagnosis, sex, race and the status of ulceration at the primary site and the stages at diagnosis were similar between patients with a C-MET mutation and those with wild type. There were no significant differences in the overall survival from the time of stage IV diagnosis between the two groups, but there was a trend of a shorter median duration from the time of the initial diagnosis to distant metastases among patients with a C-MET mutation. (23.6 months vs. 15.9 months, p=0.09). Conclusions We found C-MET mutations in 11% of patients with malignant melanoma. There was a tendency to have distant metastasis at an earlier time in patients with a C-MET mutation. This is the first report describing the frequency and clinical characteristics of C-MET mutations in patients with malignant melanoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4588. doi:1538-7445.AM2012-4588
Dicumarol Fatality in Severe Hypertensive and Arteriosclerotic Cardiovascular Disease Despite Controlled Therapeutic Level
Authors: ROSE E. LONDON
Journal: Circulation (1950)

The following case demonstrates fatal widespread hemorrhage resulting from the use of dicumarol at what is ordinarily considered a safe and desirable therapeutic level. It is suggested that the accompanying severe hypertensive and arteriosclerotic cardiovascular disease may have injured the contiguity of the vascular tree to such an extent that active diapedesis occurred in the presence of dicumarol.
SPECIAL EXERCISE FOR INCREASING EXTENSIBILITY OF THE BACK
Authors: Philip Lewin
Journal: JAMA (1927)

The exercise is presented as a valuable one to increase the extensibility of the back and the power of the abdominal muscles. It is especially recommended in that large group of patients with contracted muscles and ligaments in the lumbar, lumbosacral and sacro-iliac regions. It is not an easy or a beginning exercise. The apparatus consists of a 1½ inch belt strap 15 inches long, fastened to the floor, and a small stool, 14 inches high, 11 inches wide and 18 inches long. The subject sits on the stool and the forefeet are slipped through the strap. The hands are placed behind the head. On the count of one, the trunk is allowed to hyperextend until the head touches the floor. It remains in this position during the counts of two and three, and on the count of four the return to the starting position is made. This
The diagnostic accuracy of Fibroscan® for cirrhosis is influenced by liver morphometry in HCV patients with a sustained virological response
Authors: Roberta D’Ambrosio, Alessio Aghemo, Mirella Fraquelli, Maria Grazia Rumi, Maria Francesca Donato, Valerie Paradis, Pierre Bedossa, Massimo Colombo
Journal: Journal of Hepatology (2013)
THE ADMINISTRATION OF BAS, 5-HTP, AND MARSILID TO SCHIZOPHRENIC PATIENTS
Authors: AARON FELDSTEIN, HARRY FREEMAN, JUSTIN M. HOPE, IRIS M. DIBNER, HUDSON HOAGLAND
Journal: American Journal of Psychiatry (1959)

The administration to 5 chronic schizophrenic patients of BAS alone, of BAS and 5-HTP combined, and of BAS and 5-HTP in conjunction with Marsilid was not therapeutically useful. The fact that the patients did not react to the presumed increase in brain serotonin casts doubt upon the hypothesis that too little or too much serotonin is causally related to schizophrenia. BAS appears to be a monoamine oxidase inhibitor. The conversion of 5-HTP to 5-HIAA was thus prevented resulting in an accumulation of serotonin in urine.
Dialogue: a link to psychosomatic illness
Authors: J. Kangilaski
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fasting and postprandial gastrointestinal motility in ulcer and non-ulcer dyspepsia.
Authors: V Stanghellini, C Ghidini, M R Maccarini, G F Paparo, R Corinaldesi, L Barbara
Journal: Gut (1992)

This study aimed to compare fasting and postprandial gastrointestinal motor patterns in patients with ulcer and non-ulcer dyspepsia. Forty five subjects were studied: 10 with uncomplicated gastric ulcer, eight with uncomplicated duodenal ulcer, 18 with chronic idiopathic dyspepsia, and nine healthy asymptomatic controls. Gastrointestinal fasting and postprandial motor patterns were recorded using a low compliance perfusion technique. The interdigestive antral cumulative motility index, computed for 30 minutes before the appearance of duodenal activity fronts, and the number of activity fronts with an antral component were significantly less in patients with ulcers and those with non-ulcer dyspepsia compared with asymptomatic controls. The patient groups also had a reduced antral motor response to a solid-liquid test meal compared with healthy controls. Intestinal motor abnormalities (bursts of non-propagated phasic pressure activity and discrete clustered contractions) were recorded in a minority of patients, all with associated irritable bowel symptoms. In conclusion, antral hypomotility is a frequent but nonspecific motor abnormality in dyspepsia; abnormal motor patterns of the small bowel are less frequent and seem to be confined to patients with concomitant irritable bowel syndrome.
Abstract 4132: Down Regulation of the CCK-B/C Receptor Inhibits Growth of Pancreatic Cancer
Authors: Kristin K. Fino, Gail L. Matters, Christopher O. McGovern, Mark Kester, Jill P. Smith
Journal: Cancer Research (2010)

Abstract Background: Pancreatic cancer has a dismal prognosis with only 1% surviving 5 years. Reasons for this poor prognosis include the inability to diagnosis pancreatic cancer in early stages and its resistance to standard chemotherapy. The gastrointestinal peptide, gastrin, has been identified as a growth factor in pancreatic cancer. Gastrin stimulates growth of pancreatic cancer through the cholecystokinin (CCK)-B receptor and a splice variant of this receptor (CCK-C), which is expressed only in cancer cells. Hypothesis: It is hypothesized that down regulation of the gastrin binding receptors, CCK-B/C, by small interfering RNAs (siRNAs) will inhibit growth of pancreatic cancer. Methods: A series of human pancreatic cancer cells were screened by Real-Time RT-PCR for the presence and quantity of CCK-B/C receptor mRNA. Receptor binding was identified in pancreatic cancer cells with a CCK-B polyclonal antibody (1:10,000) by immunocytochemistry. PANC-1 cells were transfected with siRNAs that target a region of mRNA common to both the CCK-B and CCK-C receptor with either Lipofectamine 2000 or pegylated cationic nanoliposomes previously shown to be nontoxic after systemic intravenous administration. RNA was extracted and analyzed by TaqMan Real-Time RT-PCR for the receptor expression 3 days after treatment. Control cells were untreated, vehicle only treated (Lipofectamine 2000 or pegylated cationic nanoliposomes), or treated with a scrambled siRNA control. The effects of CCK-B/C knock-down on growth were evaluated by counting cells at various time points by trypan blue dye exclusion. Results: The CCK-B/C receptor was detected in several human pancreatic cancer cell lines (PANC-1, MIA PaCa-2, AsPC-1, BxPC-3, and Capan-1) by Real-Time RT-PCR. The receptor was identified by immunofluorescence in the plasma membrane. CCK-B/C receptor expression was down regulated by CCK-B/C siRNA with both Lipofectamine 2000 and pegylated cationic nanoliposomes. PANC-1 cell growth was significantly decreased in CCK-B/C receptor targeted siRNA treated cells compared to untreated cells, vehicle only, and scrambled control on day 3 (p&amp;lt;0.0001, n=9). Control cells more than doubled in number while CCK-B/C siRNA treated cells increased by only 10%. Conclusion: The CCK-B/C receptor is present in human pancreatic cancer cells and knock-down significantly decreases cell growth. Systemic administration of CCK-B/C siRNAs by pegylated cationic nanoliposomes may be a potential therapeutic modality for pancreatic cancer. Supported by NIH CA117926. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4132.
Nitrogen Dioxide Toxicity Report of Four Cases in Firemen
Authors: Rose L. Tse
Journal: JAMA (1970)

Four firemen with acute toxic reactions to nitrogen dioxide were observed over a period of 18 months. A wide spectrum of responses was noted. All had initial symptoms of acute toxic conditions. One subsequently developed chronic pulmonary insufficiency; the other three eventually became asymptomatic. Since initial symptoms of acute toxic conditions are often minimal and delayed onset of respiratory distress and superimposed bacterial infection are distinct possibilities, patients with significant exposure should be hospitalized and observed for at least 48 hours. After discharge from the hospital, these patients should be closely observed for at least an additional six weeks, since the second acute phase of the illness, which may be fatal, usually occurs during this period. Certain studies on chronic exposure of animals to low concentrations of nitrogen dioxide, an important air pollutant, are reviewed.
Corsage Pin in Stomach
Authors: Robert Ray McGee
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The article, "Corsage Pin in Stomach" (<i>JAMA</i><b>175</b>:48 [Jan. 7] 1961), illustrates a useful lesson in the management of a common problem. Something else is noteworthy about it. Here, at last, is a medical paper with more authors (5) than paragraphs (3). I believe this probably represents a new high in authorship by committee. May we eventually look forward to an article in which the list of authors' names will require more type than the article itself?
Topical tacrolimus for cutaneous lupus erythematosus: reply from authors
Authors: S.L. Walker, B. Kirby, R.J.G. Chalmers
Journal: British Journal of Dermatology (2003)

Sir, Mrs Chambers is correct to highlight the fact that topical tacrolimus (Protopic® 0·03% and 0·1% ointment) is now available in the U.K. This was not, however, the case either when we were treating our patients or when our manuscript was accepted for publication.1 Since then, another report of the use of topical tacrolimus for cutaneous lupus erythematosus (LE) has been published.2 Eleven patients were treated with tacrolimus 0·1% ointment once daily for 4 weeks. None of three patients with discoid LE responded although four patients with less infiltrated, erythematous skin lesions of systemic or subacute cutaneous LE and two with dermatomyositis did show marked improvement. We have highlighted the dramatic superiority of the combination of 0·3% tacrolimus in 0·05% clobetasol propionate used twice daily over the corticosteroid alone in two patients with recalcitrant chronic discoid LE;1, 3 we are currently undertaking a formal study to compare these treatments in a larger number of patients. The contrasting findings reported by Yoshimasu et al.2 might be explained by chance but are more likely to be due either to inadequate penetration of the 0·1% tacrolimus preparation, which was applied only once daily, into the thick, infiltrated plaques of discoid LE or, alternatively or additionally, to a synergistic effect between tacrolimus and potent topical corticosteroids in our patients. It is important for the place of topical tacrolimus in cutaneous LE to be clarified in controlled clinical trials.
Acute Leukemia with "Burkitt's Lymphoma Cells" and Burkitt's Lymphoma
Authors: DAVID A. STEVENS
Journal: Annals of Internal Medicine (1972)

Hematologic neoplasms developed simultaneously in two American siblings. One patient succumbed to a malignant lymphoma, undifferentiated, Burkitt's type, a rare tumor in the United States. His sister developed acute leukemia with cells identical to those seen in Burkitt's lymphoma, a presentation that has not been previously described. We suggest that this latter entity be called acute leukemia, undifferentiated, Burkitt's type. The cytological features of these diseases are described and illustrated. Epidemiological patterns of Burkitt's lymphoma in Africa suggest an infectious cause. The simultaneous occurrence of histologically identical tumors in these siblings is consistent with an infectious cause, with a fixed or short incubation period, possibly superimposed on a genetic susceptibility. The family history is unremarkable, as were the results of several serological tests of the patients' serums against Epstein-Barr virus, a potential causative agent in Burkitt's lymphoma.
Facial vein in the rabbit. Neurogenic vasodilation mediated by beta-adrenergic receptors.
Authors: B L Pegram, R D Bevan, J A Bevan
Journal: Circulation Research (1976)

A segment of the facial vein of the rabbit, that opposite the buccal cavity, responds to norepinephrine (NE) and opposite the buccal cavity, responds to norepinephrine (NE) and transmural nerve stimulation (TNS) by a brisk biphasic dilation. The dilation in response to both procedures is reveresed by prior exposure to propranolol (10(-6)M). Pretreatment with phenoxybenzamine (10(-5)M) increases the size of the neurogenic response and displaces the NE dose-relaxation curve to the left. Histamine causes a constrictor response exclusively. Sympathetic stimulation of a segment of the facial vein proximal to this buccal segment, and also of the external jugular vein, results in constriction. Light microscopy showed no fequtres which can account for the dilation, and fluorescence histochemistry using a modified Flack technique showed a dense adrenergic nerve plexus extending throughout the thickness of the media. We found that frequency-response characteristics and neuronal uptake of 3H-NE were consistent with findings for a blood vessel with a heavy medial innervation. Also, monoamine oxidase and catechol O-methyltransferase activities were similar to those found in other rabbit veins. Furthermore, these results are consistent with an adrenergic neuroeffector organization in which there is a predominance of beta- over alpha-adrenergic receptors. In conclusion, the presence of a dilator response in this buccal segment of the facial vein may be related to its location in the wall of the cheek, where it may be subjected to considerable stretch.
Assurance Office Fees
Authors: R. Cartwright
Journal: BMJ (1843)

POISONING.M. Ducros forwarded an account of various experi- ments which showed that the symptoms of poisoning with strychnine and brucine were completely arrested by means of a machine affording negative electricity.On the other hand, the poisoning was rapidly hastened bypositive electricity.The movements ofextension and flexion of the limbs also hasten the period of death, even more so than positive electricity.Lastly, both kinds of electricity hasten poisoning with arsenious acid.The animals submitted to experiment were rabbits, dogs, and guinea-pigs.CIRCULATION THROUGH THE CAPILLARIES.
Prognostic Significance of Ultrasound Myocardial Tissue Characterization in Patients With Cardiac Amyloidosis
Authors: Jun Koyama, Patricia A. Ray-Sequin, Rodney H. Falk
Journal: Circulation (2002)

Background — Cycle-dependent variation of myocardial integrated backscatter (CV-IB) is an objective measurement that may detect myocardial abnormalities. However, no data exist about the prognostic value of CV-IB in primary cardiac amyloidosis. Methods and Results — We prospectively examined 208 consecutive biopsy-proven patients with primary amyloidosis. The magnitude of CV-IB was analyzed at the interventricular septum and left ventricular (LV) posterior wall and its prognostic value was compared with standard Doppler measurements with to the Tei index (isovolumic contraction time plus isovolumic relaxation time divided by ejection time). One hundred thirty-three patients had cardiac involvement (mean LV thickness &gt; 12 mm). Forty-one patients (20%) (32 cardiac deaths) died during a mean follow-up of period of 307±156 days. Univariate analysis showed that the CV-IB at the LV posterior wall was the best predictor of cardiac death ( P &lt;0.0001) and all-cause death ( P &lt; 0.0001). The Tei index did not identify patients at risk of death. Multivariate analysis showed that CV-IB at the LV posterior wall was the only independent predictor of both cardiac and overall deaths. Conclusions — Among patients with cardiac amyloidosis, CV-IB at the LV posterior wall is a powerful predictor of clinical outcome and is superior to standard echocardiographic/Doppler flow indexes.
CATALYTIC IRON IN ACUTE MYOCARDIAL INFARCTION COMPLICATED BY CARDIOGENIC SHOCK: A BIOMARKER SUBSTUDY OF THE IABP-SHOCK II-TRIAL
Authors: Georg Fuernau, Florian Traeder, Suhas Lele, Mohan M. Rajapurkar, Banibrata Mukhopadhyay, Steffen Desch, Ingo Eitel, Gerhard Schuler, Volker Adams, Holger Thiele
Journal: Journal of the American College of Cardiology (2015)
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
Authors: Shigehisa Yanagi, Hiroyuki Kishimoto, Kohichi Kawahara, Takehiko Sasaki, Masato Sasaki, Miki Nishio, Nobuyuki Yajima, Koichi Hamada, Yasuo Horie, Hiroshi Kubo, Jeffrey A. Whitsett, Tak Wah Mak, Toru Nakano, Masamitsu Nakazato, Akira Suzuki
Journal: Journal of Clinical Investigation (2007)

PTEN is a tumor suppressor gene mutated in many human cancers. We generated a bronchioalveolar epithelium–specific null mutation of Pten in mice [SP-C-rtTA/(tetO)7-Cre/Ptenflox/flox (SOPtenflox/flox) mice] that was under the control of doxycycline. Ninety percent of SOPtenflox/flox mice that received doxycycline in utero [SOPtenflox/flox(E10–16) mice] died of hypoxia soon after birth. Surviving SOPtenflox/flox(E10–16) mice and mice that received doxycycline postnatally [SOPtenflox/flox(P21–27) mice] developed spontaneous lung adenocarcinomas. Urethane treatment accelerated number and size of lung tumors developing in SOPtenflox/flox mice of both ages. Histological and biochemical examinations of the lungs of SOPtenflox/flox(E10–16) mice revealed hyperplasia of bronchioalveolar epithelial cells and myofibroblast precursors, enlarged alveolar epithelial cells, and impaired production of surfactant proteins. Numbers of bronchioalveolar stem cells (BASCs), putative initiators of lung adenocarcinomas, were increased. Lungs of SOPtenflox/flox(E10–16) mice showed increased expression of Spry2, which inhibits the maturation of alveolar epithelial cells. Levels of Akt, c-Myc, Bcl-2, and Shh were also elevated in SOPtenflox/flox(E10–16) and SOPtenflox/flox(P21–27) lungs. Furthermore, K-ras was frequently mutated in adenocarcinomas observed in SOPtenflox/flox(P21–27) lungs. These results indicate that Pten is essential for both normal lung morphogenesis and the prevention of lung carcinogenesis, possibly because this tumor suppressor is required for BASC homeostasis.
Energetic Crosstalk Between Organelles
Authors: Allen Kaasik, Vladimir Veksler, Ernest Boehm, Marta Novotova, Ave Minajeva, Renée Ventura-Clapier
Journal: Circulation Research (2001)

Cells with high and fluctuating energy demands such as cardiomyocytes need efficient systems to link energy production to energy utilization. This is achieved in part by compartmentalized energy transfer enzymes such as creatine kinase (CK). However, hearts from CK-deficient mice develop normal cardiac function under conditions of moderate workload. We have therefore investigated whether a direct functional interplay exists between mitochondria and sarcoplasmic reticulum or between mitochondria and myofilaments in cardiac cells that catalyzes direct energy and signal channeling between organelles. We used the selective permeabilization of sarcolemmal membranes with saponin to study the functional interactions between organelles within the cellular architecture. We measured contractile kinetics, oxygen consumption, and caffeine-induced tension transients. The results show that in hearts of normal mice, ATP produced by mitochondria (supplied with substrates, oxygen, and adenine nucleotides) was able to sustain calcium uptake and contractile speed. Moreover, direct mitochondrially supplied ATP was nearly as effective as CK-supplied ATP and much more effective than externally supplied ATP, suggesting that a direct ATP/ADP channeling exists between the sites of energy production (mitochondria) and energy utilization (sarcoplasmic reticulum and myofilaments). On the other hand, in cardiac cells of mice deficient in mitochondrial and cytosolic CK, marked cytoarchitectural modifications were observed, and direct adenine nucleotide channeling between mitochondria and organelles was still effective for sarcoplasmic reticulum and myofilaments. Such direct crosstalk between organelles may explain the preserved cardiac function of CK-deficient mice under moderate workloads.