Bilateral Enlargement of the Lacrimal Glands From IgG4-Related Systemic Disease
Authors: Nathalie Morel
Journal: Annals of Internal Medicine (2012)

Letters1 May 2012Bilateral Enlargement of the Lacrimal Glands From IgG4-Related Systemic DiseaseNathalie Morel, MD, Aude Rigolet, MD, Nicolas Schleinitz, MD, PhD, Alice Garnier, MD, and Nathalie Costedoat-Chalumeau, MD, PhDNathalie Morel, MDFrom Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Université de la Méditerranée Aix-Marseille II, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13385 Marseille, France;and Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France.Search for more papers by this author, Aude Rigolet, MDFrom Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Université de la Méditerranée Aix-Marseille II, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13385 Marseille, France;and Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France.Search for more papers by this author, Nicolas Schleinitz, MD, PhDFrom Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Université de la Méditerranée Aix-Marseille II, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13385 Marseille, France;and Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France.Search for more papers by this author, Alice Garnier, MDFrom Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Université de la Méditerranée Aix-Marseille II, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13385 Marseille, France;and Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France.Search for more papers by this author, and Nathalie Costedoat-Chalumeau, MD, PhDFrom Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Université de la Méditerranée Aix-Marseille II, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13385 Marseille, France;and Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-9-201205010-00020 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This article has been corrected. The original version (PDF) is appended to this article as a supplement.Background: Immunoglobulin G4–related systemic disease was first described in 2003. It is a chronic inflammatory disorder defined by the presence of tissue-infiltrating plasma cells bearing IgG4. The association with IgG4 is a relatively recent finding, and the condition has previously been described under numerous other names.Objective: To increase awareness of this recently described disease to avoid unnecessary investigations and reduce the time to diagnosis.Case Report: In January 2011, physicians referred a 22-year-old man to our center for lymphadenopathy and lacrimal gland ...References1. Ebbo M, Daniel L, Pavic M, Sève P, Hamidou M, Andres E, et al. IgG4-related systemic disease: features and treatment response in a French cohort: results of a multicenter registry. Medicine (Baltimore). 2012;91:49-56. [PMID: 22198501] CrossrefMedlineGoogle Scholar2. Khosroshahi A, Stone JH. A clinical overview of IgG4-related systemic disease [Editorial]. Curr Opin Rheumatol. 2011;23:57-66. [PMID: 21124086] CrossrefMedlineGoogle Scholar3. Okazaki K, Uchida K, Koyabu M, Miyoshi H, Takaoka M. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease. J Gastroenterol. 2011;46:277-88. [PMID: 21452084] CrossrefMedlineGoogle Scholar4. Zhang L, Smyrk TC. Autoimmune pancreatitis and IgG4-related systemic diseases. Int J Clin Exp Pathol. 2010;3:491-504. [PMID: 20606730] MedlineGoogle Scholar5. Zen Y, Nakanuma Y. IgG4-related disease: a cross-sectional study of 114 cases. Am J Surg Pathol. 2010;34:1812-9. [PMID: 21107087] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France; Université de la Méditerranée Aix-Marseille II, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13385 Marseille, France;and Université Pierre et Marie Curie-Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, 75651 Paris Cedex 13, France.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCorrection: Bilateral Enlargement of the Lacrimal Glands From IgG4-Related Systemic Disease Metrics Cited ByClinical observation of orbital IgG4‑related diseasesA Case of High IgG4 Serum Level with DacryoadenitisOphthalmic manifestations of IgG4-related disease: Single-center experience and literature reviewUsefulness of 2-[ 18 F]-fluoro-2-deoxy- d -glucose-Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4-Related Disease: A Retrospective Multicenter Study 1 May 2012Volume 156, Issue 9Page: 669-670KeywordsBiopsyComputed axial tomographyKidneysLymph nodesPancreasPancreatitisPlasma cellsSalivary glandsSystemic diseasesThyroid ePublished: 1 May 2012 Issue Published: 1 May 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...