tbuckley/cabot-search huggingface dataset:
Chlorpropamide Hyponatremia
Authors: Peter N. Weissman, Louis Shenkman, Robert I. Gregerman
Journal: New England Journal of Medicine (1971)

In five patients symptomatic hyponatremia developed during chlorpropamide therapy for diabetes mellitus. Chlorpropamide administration was associated with hyponatremia and serum hypoosmolality, continued sodium excretion despite hyponatremia and an impaired ability to dilute urine maximally and to excrete a water load. Clinical and chemical abnormalities were corrected by withdrawal of chlorpropamide and reappeared when the drug was readministered. This phenomenon represents a drug-induced reversible form of the syndrome of inappropriate activity of antidiuretic hormone due to enhancement of action by chlorpropamide. The reason for the development of hyponatremia in only a small percentage of persons receiving the drug is not clear. The syndrome was seen in 4 per cent of patients receiving chlorpropamide in a clinic population. This may be related to individual variation in ability to suppress endogenous antidiuretic hormone in response to hypo-osmolality.
OPTIMAL INTRAVASCULAR ULTRASOUND CRITERIA AND THEIR ACCURACY FOR DEFINING THE FUNCTIONAL SIGNIFICANCE OF INTERMEDIATE CORONARY STENOSES OF DIFFERENT LOCATIONS
Authors: Bon Kwon Koo, Hyoung-Mo Yang, Joon Hyung Doh, Chang-Hwan Yoon, Chang-Wook Nam, Seung-Ho Hur, Hong-Seok Lim, Myeong-Ho Yoon, Kyung-Woo Park, Sue-Kyung Park, Hyo-Soo Kim, Seung-Jea Tahk
Journal: Journal of the American College of Cardiology (2011)
Notch Signaling Regulates Endothelial Progenitor Cell Activity During Recovery From Arterial Injury in Hypercholesterolemic Mice
Authors: Masaaki Ii, Kyosuke Takeshita, Kayoko Ibusuki, Corinne Luedemann, Andrea Wecker, Elizabeth Eaton, Tina Thorne, Takayuki Asahara, James K. Liao, Douglas W. Losordo
Journal: Circulation (2010)

Background— Little is known about the role of endothelial progenitor cells (EPCs) in atherosclerosis. Accordingly, we performed a series of assessments with hypercholesterolemic (apolipoprotein E–null [ApoE −/− ]) and wild-type (WT) mice to evaluate how cholesterol influences reendothelialization, atherosclerosis, and EPC function after arterial injury. Methods and Results— Unexpectedly, reendothelialization (assessed by resistance to Evans blue staining) and circulating EPC counts (EPC culture assay) were greater in ApoE −/− mice than in WT mice, and transplantation of ApoE −/− bone marrow in WT mice accelerated endothelial recovery and increased recruitment of bone marrow–derived EPCs to the neoendothelium. Cholesterol concentration-dependently promoted the proliferation (MTS assay) of both ApoE −/− and WT EPCs, and the concentration dependence of EPC adhesion (to vitronectin-, collagen type I–, fibronectin-, and laminin-coated plates), migration (modified Boyden chamber assay), and antiapoptotic (terminal deoxynucleotidyl transferase–mediated dUTP nick-end labeling stain) activity was biphasic. Cholesterol enhanced the messenger RNA expression (quantitative, real-time reverse-transcription polymerase chain reaction) of vascular endothelial growth factor and inhibited Notch1 messenger RNA expression in both ApoE −/− and WT EPCs, whereas endothelial nitric oxide synthase messenger RNA expression increased in ApoE −/− EPCs and declined in WT EPCs after cholesterol exposure. EPC activity was greater in Notch1 +/− EPCs than in WT EPCs, and transplantation of Notch1 +/− bone marrow accelerated endothelial recovery after arterial injury in WT mice. Conclusion— The results presented here provide novel insights into the role of EPCs during atherosclerosis and suggest that cholesterol and Notch1 may be involved in the regulation of EPC activity.
The Grasmus Wilson Lectures ON THE PATHOLOGY AND SYMPTOMS OF ADENOCARCINOMA OF THE RECTUM: Delivered before the Royal College of Surgeons of England
Authors: C. B. Ball
Journal: BMJ (1903)

forward case in a rather desperate condition.An incision was at once made over the caecum, and a quantity of greenish gangrenous fluid at once escaped with flakes of lymph.I then drew gently on a mass presenting in the wound, and at
The Presynaptic Active Zone Protein Bassoon Is Essential for Photoreceptor Ribbon Synapse Formation in the Retina
Authors: Oliver Dick, Susanne tom Dieck, Wilko Detlef Altrock, Josef Ammermüller, Reto Weiler, Craig Curtis Garner, Eckart Dieter Gundelfinger, Johann Helmut Brandstätter
Journal: Neuron (2003)
Is still inequitable
Authors: V. S. Raleigh, F. Frosini, J. Appleby, H. Gao
Journal: BMJ (2010)

Judge and colleagues report that access to joint surgery in England in 2002 was inequitable, with poorer access relative to need for selected sociodemographic groups.1 We analysed age and sex standardised primary hip and knee replacement rates in England by primary care trust using hospital episode statistics for 2009-10. We examined the relation …
Treatment of autoimmune hepatitis with budesonide
Authors: A SCHULER
Journal: Hepatology (1995)

Until recently the only clinically recognized hormone-producing endocrine tumors of the pancreas were insulinomas and gastrinomas. We have now learned to recognize, in addition, the glucagonoma syndrome1 and vasoactive intestinal polypeptidoma (VIPoma) syndrome.2 In 1976, the production of pancreatic polypeptide by pancreatic endocrine tumors was also described.3 The presence of the somatostatin-producing D cell in the islets of Langerhans4 made it likely that somatostatinomas would also exist. Two such tumors have now been described,5.6 but their incidence and the inclusion of D cells in other pancreatic endocrine tumor types has not been investigated. Following the discovery of VIPomas in the pancreas VIP was found to also be produced by neural tumors (e.g., ganglioneuromas and ganglioneuroblastomas7.8). This dual tumor localization reflected the role of VIP as both a neurotransmitter and product of endocrine cells. Somatostatin has a similar dual role and could therefore also be expected to be the product of certain neural tumor types.
Quantitative Determination of Antibody to Gonococcal Pili. CHANGES IN ANTIBODY LEVELS WITH GONOCOCCAL INFECTION
Authors: Thomas M. Buchanan, John Swanson, King K. Holmes, Stephen J. Kraus, Emil C. Gotschlich
Journal: Journal of Clinical Investigation (1973)

Gonococcal pili, pure by the criteria of electron microscopic examination and polyacrylamide gel electrophoresis in sodium dodecyl sulfate, have been prepared by repeated cycles of precipitation with 0.1 M MgCl(2), followed by dissolution in 0.01 M Tris pH 8, 0.01 M NaN(3). Using a fluorescein-conjugated antibody prepared to pili from a single strain, pilar antigen(s) was found to be present in each of 18 strains of gonococci tested, and absent from strains of pilated meningococci, nonpathogenic Neisseria sp., and Escherichia coli. Purified pili, labeled with (125)I were used in an antigen binding assay to quantitatively measure antibody to pili in rabbit sera and in 561 human sera. The range of antibody activity for 133 persons unlikely to have experienced gonorrhea was 0.1-1.6 mug/ml with a geometric mean of 0.5 mug/ml. This geometric mean antibody activity was significantly lower than the geometric mean for asymptomatically infected males (1.0 mug/ml, P < 0.002), males with symptomatic gonococcal anterior urethritis (1.6 mug/ml, P < 0.001), or asymptomatically infected females (4.2 mug/ml, P < 0.001). Antibody appeared in elevated levels (> 1.6 mug/ml) 2-3 wk after infection and returned toward control levels 1 or more months after treatment. Antibody levels higher than 1.6 mug/ml were found in 26 (50%) of 52 males with gonococcal anterior urethritis, in 10 (33%) of 30 males with asymptomatic urethral infection and in 50 (89%) of 56 asymptomatically infected females. In a high-risk group of 103 females for whom culture results and antibody to pili were compared, 58 (57%) had elevated antibody levels to pili and 86% of the infected females were within this seropositive group. The antigen binding assay may provide a means to detect asymptomatic gonococcal infection in women.
Rebooting Cancer Tissue Handling in the Sequencing Era
Authors: Laura Goetz, Kelly Bethel, Eric J. Topol
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obama calls on Congress to fund $6.2bn emergency Ebola initiative
Authors: M. McCarthy
Journal: BMJ (2014)

At a speech given on 2 December at the US National Institutes of Health, President Barack Obama called on Congress to pass his $6.2bn (£4bn; €5bn) funding request for emergency Ebola programs before its recess for the holiday period.

“For the most part, people have recognized this is not a Democratic issue or a Republican issue—it’s about the safety and security of the American people. So let’s get it done,” said the president.

Obama noted that, although the Ebola outbreak was …
Correlation between CD34 expression and chromosomal abnormalities but not clinical outcome in acute myeloid leukemia
Authors: Christophe Fruchart, Bernard Lenormand, Christian Bastard, Dominique Boulet, Jean-François Lesesve, Marie-Paule Callat, Aspasla Stamatoullas, Mathleu Monconduit, Herve Tilly
Journal: American Journal of Hematology (1996)

The hemopoietic stem cell marker CD34 has been reported to be a useful predictor of treatment outcome in acute myeloid leukemia (AML). Previous data suggested that CD34 expression may be associated with other poor prognosis factors in AML such as undifferentiated leukemia, secondary AML (SAML), and clonal abnormalities involving chromosome 5 and 7. In order to analyze the correlations between the clinicopathologic features, cytogenetic and CD34 expression in AML, we retrospectively investigated 99 patients with newly diagnosed AML: 85 with de novo disease and 14 with secondary AML (SAML). Eighty-six patients who received the same induction chemotherapy were available for clinical outcome. Defining a case as positive when > or = 20% of bone marrow cells collected at diagnosis expressed the CD34 antigen, forty-five patients were included in the CD34 positive group. Ninety patients had adequate cytogenetic analysis. Thirty-two patients (72%) with CD34 positive AML exhibited an abnormal karyotype whereas 15 patients (28%) with CD34 negative AML had abnormal metaphases (P < 0.01). Monosomy 7/7q- or monosomy 5/5q- occurred in 10 patients and 8 of them expressed the CD34 antigen (P < 0.05). All patients with t(8;21) which is considered as a favorable factor in AML had levels of CD34 >/= 20% (P < 0.05). We did not find any association between CD34 expression and attainment of complete remission, overall survival, or disease-free survival. In conclusion, the variations of CD34 expression in AML are correlated with cytogenetic abnormalities associated both with poor and favorable outcome. The evaluation of the correlations between CD34 antigen and clinical outcome in AML should take into account the results of pretreatment karyotype.
Cyclosporine A and NAC on the inducible nitric oxide synthase expression and nitric oxide synthesis in rat renal artery cultured cells
Authors: Camila Lessio, Fábio De Assunção Silva, Maria Aparecida Glória, Ana Beatriz Galhardi Di Tommaso, Margaret Gori Mouro, Giovana Seno Di Marco, Nestor Schor, Elisa Mieko Suemitsu Higa
Journal: Kidney International (2005)
ANTITHROMBOTIC MANAGEMENT OF ACUTE CORONARY SYNDROME IN PATIENTS WITH ATRIAL FIBRILLATION IN THE INTERMOUNTAIN HEART COLLABORATIVE STUDY
Authors: Viet T. Le, Stacey Knight, Winslow Klaskala, Scott C. Woller, Benjamin Horne, Thomas Bunch, Roger Mills, J. Muhlestein
Journal: Journal of the American College of Cardiology (2013)
Staging anorexia nervosa could improve outcomes, say experts
Authors: J. Parry
Journal: BMJ (2012)

The current criteria for diagnosing anorexia nervosa fail to reflect clinical reality and should be changed to a staging model similar to that used to diagnose cancer or burns, says an Australian expert.

Stephen Touyz, professor of clinical psychology and co-director of the Peter Beumont Centre for Eating Disorders at the University of Sydney, says that a staging instrument developed by Sarah Maguire of the university’s School of Psychology and colleagues can be used by clinicians to evaluate the severity of anorexia nervosa, enabling patients to be identified and treated earlier.

He said, “Under the existing criteria anorexia nervosa is only diagnosed when it is full blown. People who have symptoms of anorexia nervosa but …
Margaret Carroll Watkinson (nee Smith)
Authors: D. H Watkinson
Journal: BMJ (2003)

Former family planning doctor Blackburn, Cheltenham, and Cirencester (b Fulwood, Preston, Lancashire, 1921; q Durham 1949), died in Charlbury, Oxfordshire, on 13 September 2003.​2003.




Figure 1




In 1953 she opened a clinic in the Friends Meeting House, Blackburn, where it continued for seven years until the local authority provided more suitable premises. She conducted one or more sessions every week, in Blackburn until 1978 and from 1978 to 1986 in Cheltenham and Cirencester. From 1953 to 1970 she worked as an anaesthetist in Burnley and Blackburn hospital groups, while her family planning work demanded an extension of her skills into psychosexual counselling. This led her to explore the use of hypnosis in the relief of postoperative pain. She leaves a husband, Deryck; two daughters; and five grandchildren.
Adult onset of cow's milk protein allergy with small‐intestinal mucosal IgE mast cells
Authors: F. S. Levy, A. J. Bircher, J.‐O. Gebbers
Journal: Allergy (1996)

We report a female patient with adult onset of cow's milk protein allergy. For 1 year, she experienced repeated gastrointestinal symptoms and had a single exercise‐induced anaphylactic reaction. In addition to positive skin tests and specific IgE to milk proteins and a positive challenge test, immunohistochemistry of the small intestine showed a marked increase of IgE‐positive mast cells. This finding is highly specific and could provide an additional tool for diagnosing cow's milk protein allergy and possibly also other food allergies.
Botulism or Polio-encephalomyelitis?
Authors: A. H. Gale
Journal: BMJ (1949)

<h3>Abstract</h3> Nearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS)<sup>1–4</sup>. However, the impact of rare coding variants on depression remains poorly understood. Here, we present the largest to date exome analysis of depression based on 320,356 UK Biobank participants. We show that the burden of rare disruptive coding variants in loss-of-function intolerant genes is significantly associated with depression risk. Among 30 genes with false discovery rate (FDR) &lt;0.1, <i>SLC2A1</i>, a blood-brain barrier glucose transporter underlying GLUT1 deficiency syndrome<sup>5–7</sup>, reached exome-wide significance (<i>P</i>=2.96e-7). Gene-set enrichment supports neuron projection development and muscle activities<sup>2, 3</sup> as implicated in depression. Integrating exomes with polygenic risk revealed additive contributions from common and rare variants to depression risk. The burden of rare disruptive coding variants for depression overlapped with that of developmental disorder, autism and schizophrenia. Our study provides novel insight into the contribution of rare coding variants on depression and genetic relationships across developmental and psychiatric disorders.
WHO steps up efforts against trachoma
Authors: Z. Kmietowicz
Journal: BMJ (1996)

The World Health Organization (WHO) has developed a strategy, SAFE, to eradicate trachoma globally: it includes surgery for trichiasis, antibiotics, facial cleanliness, and environmental improvement. Goals of the alliance of governments, international organizations, and nongovernmental organizations assembled by WHO include: 1) to identify countries where trachoma is epidemic; 2) to map the disease; 3) to initiate community-based hygiene programs; and 4) to make surgery widely available. 15% of the world's blindness is due to trachoma; about 6 million people have been irreversibly blinded, and an estimated 146 million require treatment to avoid blindness. David Mabey, professor of communicable diseases at the London School of Hygiene and Tropical Medicine, describes trachoma, which is spreading in Africa, as "the forgotten disease of the poorest people in the world." The disease, which is caused by Chlamydia trachomatis, is associated with overcrowding, poor hygiene, and limited access to water and sanitation. Contact with the eye discharge of an infected person, or with flies that seek eyes, transmits the disease. Treatment with tetracycline requires daily doses of eye ointment for 6 weeks. Azithromycin, which is expensive, can be given in 1 dose, and is currently being tested. Since people are reinfected quickly, whole communities are being treated in studies in Gambia and Tanzania. A vaccine is being developed.
Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol-based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group
Authors: N. Stutz, D. Becker, U. Jappe, S.M. John, A. Ladwig, P. Spornraft-Ragaller, W. Uter, H. Löffler
Journal: British Journal of Dermatology (2008)

Journal Article Nurses' perceptions of the benefits and adverse effects of hand disinfection: alcohol‐based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group Get access N. Stutz, N. Stutz Department of Dermatology, Philipp University, Marburg, Germany Correspondence: Nathalie Stutz. E‐mail: stutz@med.uni‐marburg.de Search for other works by this author on: Oxford Academic Google Scholar D. Becker, D. Becker Department of Dermatology, Johannes Gutenberg University, Mainz, Germany Search for other works by this author on: Oxford Academic Google Scholar U. Jappe, U. Jappe Department of Dermatology, Ruprecht Karls University, Heidelberg, Germany Search for other works by this author on: Oxford Academic Google Scholar S.M. John, S.M. John Department of Dermatology, University of Osnabrück, Osnabrück, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Ladwig, A. Ladwig Department of Dermatology, Ernst Moritz Arndt University, Greifswald, Germany Search for other works by this author on: Oxford Academic Google Scholar P. Spornraft‐Ragaller, P. Spornraft‐Ragaller Department of Dermatology, Technical University, Dresden, Germany Search for other works by this author on: Oxford Academic Google Scholar W. Uter, W. Uter Department of Biometry and Epidemiology, Friedrich Alexander University, Erlangen‐Nürnberg, Germany Search for other works by this author on: Oxford Academic Google Scholar H. Löffler H. Löffler Department of Dermatology, Philipp University, Marburg, GermanyDepartment of Biometry and Epidemiology, Friedrich Alexander University, Erlangen‐Nürnberg, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 3, 1 March 2009, Pages 565–572, https://doi.org/10.1111/j.1365-2133.2008.08951.x Published: 01 March 2009
Enhancement of Gene Transfer to Human Myeloid Cells by Adenovirus–Fiber Complexes
Authors: Ronald R Nepomuceno, Lars Pache, Glen R Nemerow
Journal: Molecular Therapy (2006)

Adenoviral (Ad) vectors are currently being developed for immunotherapy and vaccine delivery, particularly for cancer and antiviral treatment (e.g., human immunodeficiency virus vaccine). However, the inefficient transduction of antigen-presenting cells of myeloid lineage such as dendritic cells (DCs) by conventional Ad5-based vectors limits these applications. DCs lack the coxsackie and adenovirus receptor but express CD46, a member of the family of complement regulatory proteins, as well as sialic acid glycoconjugates, a situation that allows infection by Ad type 37 as well as most subgroup B Ads. In this study, we generated recombinant Ad fiber knobs (FKs) to probe Ad37 receptor usage on immune cells. Remarkably, treatment of human myeloid cells with Ad37 FK (37FK) enhanced, rather than inhibited transduction by Ad5 or Ad37 pseudotyped virions. The enhanced gene transfer was dose dependent, involved association with alpha(2,6)-linked sialic acid residues, and was limited to blood cells of myeloid lineage, including immature and mature DCs. We also provide evidence that 37FK binds directly to Ad5 virus particles, likely acting as a bridge to facilitate greater virus-cell interaction.
Visualization of Early Engraftment in Clinical Islet Transplantation by Positron-Emission Tomography
Authors: Torsten Eich, Olof Eriksson, Torbjörn Lundgren
Journal: New England Journal of Medicine (2007)

To the Editor: Although islet transplantation is an option for patients with type 1 diabetes, even those who become insulin-independent after engraftment have islet-graft function that is estimated...
Retrieval and analysis of particulate debris after saphenous vein graft intervention
Authors: John G. Webb, Ronald G. Carere, Renu Virmani, Donald Baim, Paul S. Teirstein, Patrick Whitlow, Colleen McQueen, Frank D. Kolodgie, Elizabeth Buller, Arthur Dodek, G.B.John Mancini, Stephen Oesterle
Journal: Journal of the American College of Cardiology (1999)
Obesity: Associations with Acute Mountain Sickness
Authors: Ge Ri-Li, Paul J. Chase, Sarah Witkowski, Brenda L. Wyrick, Jeff A. Stone, Benjamin D. Levine, Tony G. Babb
Journal: Annals of Internal Medicine (2003)

Background: Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively. Objective: To determine whether obesity is associated with the development of AMS. Design: Obese and nonobese men were compared at a simulated altitude of 3658 m (12 000 ft). Setting: 24 hours in a hypobaric environmental chamber. Participants: 9 obese and 10 nonobese men. Measurements: Percentage body fat (by hydrostatic weighing), Lake Louise AMS score, and Sao 2 level (by pulse oximetry) were measured. Results: Average AMS scores increased more rapidly with time spent at simulated high altitudes for obese men than for nonobese men (P < 0.001). The response of Sao 2 with exposure differed between nonobese and obese men. After 24 hours in the altitude chamber, seven obese men (78%) and four nonobese men (40%) had AMS scores of 4 or more. Conclusion: Obesity seems to be associated with the development of AMS, which may be partly related to greater nocturnal desaturation with altitude exposure.