tbuckley/cabot-search huggingface dataset:
Ventricular arrhythmias in the acute and chronic phases after acute myocardial infarction. Effect of intervention with captopril.
Authors: P Søgaard, C O Gøtzsche, J Ravkilde, A Nørgaard, K Thygesen
Journal: Circulation (1994)

BACKGROUND Ventricular arrhythmias (VAs) are independent predictors of mortality in survivors of myocardial infarction (MI), and they are more likely to be induced in dilated hearts with increased wall stress. Angiotensin-converting enzyme (ACE) inhibitors have been shown to prevent progressive dilation of the left ventricle after MI. METHODS AND RESULTS The effects of captopril were evaluated in 58 patients with left ventricular (LV) dysfunction after MI. Patients were randomized on day 7 to either placebo or captopril (50 mg daily) in a double-blind parallel study over a period of 6 months. Patients were followed up by means of ambulatory ECG monitoring and echocardiography. There was a significant increase in VA in the placebo group (P &lt; .05) in contrast to a significant decrease in the captopril group (P &lt; .05). As a consequence, there was a significant between-group difference after 6 months (P &lt; .05). Furthermore, the number of patients without VA at baseline who presented with this at the completion of the study was 6% in the captopril group versus 38% in the placebo group (P &lt; .05). At baseline as well as at the termination of the study, LV end-diastolic volume index (LVEDVI) and LV end-systolic volume index (LVESVI) were significantly increased among patients with VA (P &lt; .01). On day 180, both myocardial ischemia and an increase in the LVEDVI were independent predictors of VA; however, progressive dilation of the left ventricle was confined to the placebo patients with significant increases in the LVEDVI compared with the captopril group: 17% versus 0%, respectively (P &lt; .01). Furthermore, the duration of ambulatory ST-segment depression was significantly longer in this group compared with the captopril group (P &lt; .01). CONCLUSIONS Dilation of the left ventricle and myocardial ischemia predict VA during both the acute and chronic phases after MI. In post-MI patients with LV dysfunction, captopril has a beneficial effect on both the number of complex VAs as well as the number of patients who develop VA during the chronic phase. This is in all probability mediated through effects on both LV remodeling, LV function, and myocardial ischemia in patients who are exposed to an increased risk of undergoing progressive dilation of the left ventricle.
Aspirin Hepatotoxicity and Disseminated Intravascular Coagulation
Authors: J. A. SBARBARO
Journal: Annals of Internal Medicine (1977)

A 17-year-old girl with a clinical diagnosis of adult-type juvenile rheumatoid arthritis developed a severe hepatotoxic reaction to 3.6 g of aspirin per day. This was associated with a microangiopathic anemia and transient congestive cardiac failure. She responded well to steroids, and when all laboratory test findings were back to normal, she was "challenged" with five divided doses of aspirin (total, 3.0 g). This produced a salicylate level of 9.1 g/dl and was associated with an immediate deterioration in liver function test findings and a return of microangiopathic blood features with elevation of fibrin split products and a prolonged prothrombin time. These changes were again reversed by promptly starting steroid therapy. This case suggests that disseminated intravascular coagulation, and its rare association with hepatotoxicity, is a potentially fatal side effect of aspirin therapy.
Three quarters of German intensive care doctors and cardiologists admit to rationing treatment
Authors: A. Tuffs
Journal: BMJ (2009)

A survey that found that 77% of German doctors who work in intensive care or cardiology have withheld treatment from a non-private patient at least once in the previous six months has reignited the debate about healthcare rationing in Germany. 

The study, by ethicists from the Universities of Tubingen, Hannover, and Berlin, was published in a recent issue of the Deutsche Medizinische Wochenschrift (2009;134:1261-6, doi:10.1055/s-0029-1225273).

In May the call by Jorg-Dietrich Hoppe, president of the …
Release of Histamine from Human Leukocytes by One Preparation of IgG Oligomers*
Authors: T. Zhou, M. C. Conroy, H. Spengler, A. L. de Weck
Journal: Allergy (1985)

In preliminary experiments aimed at investigating the effect of covalently cross‐linked human myeloma subclass proteins on histamine release from human leukocytes, we observed one preparation (designated here IgG‐HR) made from pooled, purified immunoglobulin G which consistently released histamine from these cells. Dimers and trimers, but not monomers isolated from columns of Sephadex G‐200 and Ultrogel AcA22 following incubation of immunoglobulin G (Nordic Laboratories) with dimethyl suberimidate, released histamine from cells of all donors tested. In contrast, cells from the same donors showed variable responsiveness to dimers of IgE (prepared by similar techniques) or to anti‐IgE, IgG‐HR failed to release histamine from a “basophil‐rich” mononuclear cell preparation depleted of most of the erythrocytes, platelets, neutrophils and eosinophils by centrifugation through a Ficoll‐Hypaque cushion. The data suggest that IgG‐HR was releasing histamine indirectly from basophils by first interacting with another cell. IgG oligomers prepared from different sources of pooled, purified IgG failed to release histamine. Although we did not have sufficient IgG‐HR to adequately define this releasing activity, we feel that the data represent a potentially novel, if rare, mechanism of mediator release involving basophils and another cell.
Relationship between Platelet Adhesiveness and Plasma Surface Activity in Coronary Heart Disease
Authors: D. F. Davies, V. Lloyd
Journal: Cardiovascular Research (1967)

Journal Article Relationship between Platelet Adhesiveness and Plasma Surface Activity in Coronary Heart Disease Get access D. F. Davies, D. F. Davies From the Department of Pathology, West Wales General Hospital, Carmarthen Search for other works by this author on: Oxford Academic PubMed Google Scholar V. Lloyd V. Lloyd From the Department of Pathology, West Wales General Hospital, Carmarthen Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 1, Issue 2, April 1967, Pages 108–110, https://doi.org/10.1093/cvr/1.2.108 Published: 01 April 1967 Article history Received: 29 March 1966 Published: 01 April 1967
Allergen‐induced matrix metalloproteinase‐9 in nasal lavage fluid
Authors: AW Van Toorenenbergen, R Gerth van Wijk, AM Vermeulen
Journal: Allergy (1999)

extract.There were parallel decreases in the reactions to food allergens derived from banana, kiwi, and chestnut.Absolute values of IgE to latex showed no signi®cant alterations except at the end of the study, when an increase of approximately 4±6 URAST/ml was seen.However, IgE speci®c for chestnut clearly decreased during treatment from 0.72 to 0.30 kU/l).The behavior of IgG class speci®c for latex was similar to that of speci®c IgE.We did not detect latex-speci®c IgG4 during the study; however, this immunoglobulin apparently began to appear at the end of the study.Clinical symptoms improved steadily, with an evident reduction in nasal obstruction and eye manifestations.This was corroborated by the patient, who reported improvement even in areas of the hospital that produced signi®cant exposure to latex gloves, which she had previously been unable to tolerate.Acquisition of tolerance to the environment in her workplace was gradual during SIT, but was more pronounced once the maintenance period was started upon her discharge from the hospital and return to work.Because of the occupational nature of the allergy, the best provocation test for the allergen was constant exposure to latex in the workplace.However, we also used speci®c, controlled provocation tests.The patient entered a 1-m 3 airtight cabin and handled four pairs of latex gloves for 15 min; her clinical symptoms were then evaluated during the 6 h following this exposure to the allergen.Clinical examination after the provocation test showed that she had no cutaneous, eye, nasal, or bronchial symptoms during the following 6 h.In terms of local reactions, tolerance of SIT was excellent, with no delayed local reactions and only one episode of immediate local reaction during the maintenance phase (erythema with papules measuring 60 mm in mean diameter).This reaction did not require treatment or a change in the desensitization schedule.We believe that the allergenic extract is safe, at least at concentrations up to 0.4 mg latex protein.Tolerance was excellent, and, like other authors who used accelerated schedules (6), we established the MD on the basis of the appearance of a systemic reaction.We felt this to be the most prudent approach, in contrast to other studies in which the appearance of a systemic reaction led only to a change in the dose schedule (7, 8).Use of a conventional schedule would probably have allowed us to reach a higher MD, a possibility that deserves further study.We consider SIT with latex to be highly effective, and found the allergenic extract used to be safe and well tolerated.
Treatment-Refractory Depression
Authors: John Blossom
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of antigenic and allergenic components of <i>Holoptelea integrifolia</i> pollen collected from different source materials
Authors: P. Malik, A. B. Singh, S. V. Gangal, C. R. Babu
Journal: Allergy (1991)

Antigenic extracts prepared from pollen samples collected at weekly intervals during the same season did not exhibit significant variation in protein concentration. Stored pollen samples from different years, however, showed highly significant variations in protein concentration. The protein content of samples from different ecozones of India also varied (CV =± 32%). The IEF and SDS‐PAGE patterns were almost identical in samples from the same season, but were variable in the samples stored from different years and different parts of India. IgE binding proteins from different samples also varied depending on the overall protein profiles. Almost all the patients, however, showed IgE binding to four proteins at 50, 60, 66 and 70 kD, indicating the important allergenic components of Holoptelea integrifolia.
Hepatitis C virus-infected patients report communication problems with physicians
Authors: Susan Zickmund, Stephen L. Hillis, Mitchell J. Barnett, Laura Ippolito, Douglas R. LaBrecque
Journal: Hepatology (2004)

We examined the prevalence and nature of perceived problems in the interaction between physicians and patients diagnosed with hepatitis C virus (HCV) infection. This cross-sectional study included 322 outpatients diagnosed with chronic HCV infection and treated at a tertiary referral hospital's hepatology clinic. Patients were asked to provide demographic information and to complete a semistructured interview, the Sickness Impact Profile (SIP) and Hospital Anxiety Depression (HAD) scale. A team of two blinded coders analyzed the interviews. A total of 131 (41%) study patients reported communication difficulties with physicians involved in their care. The main difficulties were the poor communication skills of physicians (91 [28%]), physician incompetence regarding the diagnosis and treatment of HCV infection (74 [23%]), feelings of being misdiagnosed, misled, or abandoned (51 [16%]), or being stigmatized by their physician (29 [9%]). Patients were twice as likely to report difficulties with subspecialists as compared with generalists. Nonresponse with antiviral therapy correlated with perceived physician conflict even after adjusting for treatment in relation to the time of interview, whereas previous or ongoing substance abuse and mode of acquisition did not. In a multivariate model, patients' psychosocial problems were the best predictors of communication difficulties. In conclusion, a substantial number of patients with HCV infection report difficulties when interacting with physicians, which may be due to coexisting emotional or social problems. However, perceived stigmatization by physicians and a sense of abandonment reflect the need for further educational efforts. These should target both specialists and primary care providers to inform them about the psychosocial challenges facing these patients. (Hepatology 2004;39:999-1007.)
1068-126 Cultured adipose tissue-derived stromal cells express the stem cell marker CD34 and show evidence of differentiation into a cardiomyocyte phenotype
Authors: Jalees Rehman, Rafat Siddiqui, Jingling Li, Dmitry Traktuev, Stephanie Merfeld-Clauss, Keith L March
Journal: Journal of the American College of Cardiology (2004)
A113: TCR-independent Activation of T-cells Through CD31 Triggering as an Etiology of Cytokine Production in Juvenile Idiopathic Arthritis
Authors: Ian D. Ferguson, Patricia Griffin, Joshua Michel, Daniel Kietz, Margalit Rosenkranz, Abbe N. Vallejo
Journal: Arthritis & Rheumatology (2014)

Background/Purpose:

JIA is the banner diagnosis for a heterogenous group of rheumatic conditions characterized by local inflammation and destruction of the joint space and systemic manifestations. Pro-inflammatory cytokines derived from T cells are considered effectors of disease. Recent data has shown that some of these cytokines come directly from a distinct subset of T cells expressing CD31, an adhesion molecule expressed by granulocytes and endothelial cells. In the present work, we examined whether the array of cytokines in blood and synovial fluid of patients are the same array produced by T cells activation through CD31 ligation independent of the TCR. We propose that CD31-driven cytokine production by T cells is a self-perpetuating mechanism of local and systemic inflammation in JIA.



Methods:

Following informed consent/assent, blood and/or synovial fluid were collected from patients with oligoarticular and polyarticular JIA. Similar blood samples were also collected from healthy subjects. Cytokine composition of the plasma and/or fluid were subjected to multiplex analysis using the Luminex platform. Phenotypes of mononuclear cells in blood and synovial fluid were examined by multicolor flow cytometry. Drawing from the results of the Luminex assay, receptor crosslinking bioassays using primary CD31+ T cells (in blood and/or synovial fluid) and CD31+ T cell lines were conducted. Cytokine production by these cells were assessed by flow cytometry and/or by Luminex.



Results:

The overall cytokine signature of JIA characterized by the dominance of IL-6, IL-10 and TNFα. Unexpectedly, patients with oligoarticular disease showed higher levels of IFNγ and IL-17 family cytokines than those with polyarticular disease. Both types of patients however showed a similar cellular signature characterized by the preponderance of T cells deficient in CD4, CD8, and CD28, but expressing CD31. Results of CD31 cross-linking bioassays, using either specific antibody or its recombinant ligand CD38, showed high levels of induction of IL-2, IL-17 and IFNγ. Specificity of CD31-driven, TCR-dependent cytokine production was verified by similar bioassays using somatic somatic T cell line mutants Loucy and JRT3 that lack TCR and TCR/CD3, respectively, but are both CD31+. The observed cytokine production was associated with the phosphorylation of the signaling substrates ZAP70, cAbl, and p65-NFKB.



Conclusion:

Our data show that the cytokine signature of oligoarticular JIA appears distinct with the dominance of IFNγ and IL17. TCR independent, CD31-driven induction of these cytokines suggests maladaptive T cell function in JIA. Further investigation on the relevance of IFNγ and IL-17 to disease activity/clinical outcomes, and the CD31 signaling pathway will pave way to innovations in immunotherapy in JIA.
Superficial Wound Swabbing
Authors: Michael Schmohl, Stefan Beckert, Thomas O. Joos, Alfred Königsrainer, Nicole Schneiderhan-Marra, Markus W. Löffler
Journal: Diabetes Care (2012)

OBJECTIVE In diabetic foot ulcers, wound fluid inflammatory mediators have previously been proposed as surrogate markers for nonhealing. However, currently available wound fluid sampling techniques are not suitable for clinical practice due to low levels of exudate and a high logistical effort. The aim of this investigation was to assess 1) the technique of superficial wound swabbing for harvesting wound fluid; and 2) the quality of the collected fluid for immunoassay analysis of inflammatory mediators. RESEARCH DESIGN AND METHODS Both nylon-flocked swabs and film dressings were used to collect wound fluid from foot ulcers of diabetic patients. In randomly selected patients, levels of wound fluid inflammatory mediators and matrix metalloproteases were determined using multiplexed bead-based sandwich immunoassays with respect to both sampling methods. Wound fluid spike-in experiments were performed to evaluate the impact of different sample processing protocols on subsequent immunoassay analysis. RESULTS Using the swabbing technique, a median amount of 40 µL (2–120 µL) wound exudate was collected, which allowed the measurement of several multiplex panels. Comparing both sampling methods, a similar qualitative protein recovery was observed with a trend to analyte enrichment by swabbing. Sample processing using swabs did not affect analyte recovery, with the exception of interleukin (IL)-8, thymus and activation-regulated chemokine, IL-17A, interferon-γ–induced protein 10, and IL-4. CONCLUSIONS The quality of wound fluid collected by superficial swabbing is not inferior to the current standard technique. Combined with subsequent bead-based sandwich immunoassay analysis, this new method offers a noninvasive technique, suitable for daily clinical routines, for assessment of inflammatory activity in diabetic foot ulcers.
Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.
Authors: T Espevik, I S Figari, M R Shalaby, G A Lackides, G D Lewis, H M Shepard, M A Palladino
Journal: The Journal of Experimental Medicine (1987)

We investigated the ability of cyclosporin A (CsA) and transforming growth factor beta (TGF-beta) to modulate the production of TNF-alpha and TNF-beta and IFN-gamma by unseparated, nonadherent, and adherent PBMC. Treatment of unseparated PBMC with CsA resulted in a significant dose-dependent inhibition of all three cytokines ranging from greater than 90% inhibition for IFN-gamma and TNF-beta, to approximately 70% for TNF-alpha. Pretreatment of unseparated or nonadherent PBMC with TGF-beta inhibited the production of IFN-gamma by 60-70%. However, the inhibition of TNF-alpha and TNF-beta production by these cells was only minimally affected, and at 0.1-1 ng/ml TGF-beta could enhance TNF-alpha production by unseparated PBMC. In contrast, pretreatment of adherent PBMC with TGF-beta inhibited the production of TNF-alpha by approximately 60%. TGF-beta also inhibited both TNF-alpha production and tumor cell cytotoxicity mediated by murine peritoneal-derived macrophages. These observations indicate that the biological effects of CsA and TGF-beta on immune functions are of a wider range than previously reported.
2:1 Atrioventricular Block During Atrioventricular Node Reentrant Tachycardia
Authors: K. Ching Man, Karin Brinkman, Frank Bogun, Bradley Knight, Marwan Bahu, Raul Weiss, Rajiva Goyal, Mark Harvey, Emile G. Daoud, S. Adam Strickberger, Fred Morady
Journal: Journal of the American College of Cardiology (1996)
Radiographic patterns and associations of osteoarthritis of the knee in patients referred to hospital.
Authors: J Ledingham, M Regan, A Jones, M Doherty
Journal: Annals of the Rheumatic Diseases (1993)

OBJECTIVES--To investigate differing patterns and associations of osteoarthritis of the knee in patients referred to hospital. METHODS--Two hundred and fifty two consecutive patients (161 women, 91 men; mean age 70 years, range 34-91 years) referred to hospital with osteoarthritis of the knee underwent clinical, radiographic, and synovial fluid screening. RESULTS--Radiographic changes of osteoarthritis of the knee (definite narrowing with or without osteoarthritic features) were bilateral in 85% of patients. Of 470 knees affected, 277 (59%) were affected in two compartments and 28 (6%) in three compartments. Unilateral and isolated medial tibiofemoral osteoarthritis were more common in men. Calcium pyrophosphate crystal deposition was common (synovial fluid identification in 132 (28%) knees; knee chondrocalcinosis in 76 (30%) patients) and associated with disability, bilateral, multicompartmental and severe radiographic osteoarthritis, marked osteophytosis, attrition, and cysts. Multiple clinical nodes (58 (23%) patients) and radiographic polyarticular interphalangeal osteoarthritis (66 (26%) patients) were associated with a higher frequency of inactivity pain, disability, multicompartmental and severe radiographic change. Forestier9s disease predominated in men but showed no other associations. CONCLUSIONS--In a group of patients referred to hospital osteoarthritis of the knee is usually bilateral and affects more than one compartment. Severe and multicompartmental radiographic changes are associated with calcium pyrophosphate crystal deposition, nodal change, and polyarticular interphalangeal osteoarthritis.
Modification of polyethylene glycol estimation suitable for use with small mammals
Authors: J. M. Boulter, H. B. McMichael
Journal: Gut (1970)

Concentration of polyethylene glycol (PEG) has been measured satisfactorily using only 0·25 ml of intestinal aspirate (containing approximately 2·5 mg/l PEG). Hyden9s turbidimetric assay was modified by reading turbidity at 420 mμ. The addition of extra protein was found to facilitate filtration after protein precipitation.
THE 2.25 MILLIMETER XIENCE V® EVEROLIMUS ELUTING CORONARY STENT SYSTEM FOR THE TREATMENT OF SMALL CORONARY ARTERIES: THE SPIRIT SMALL VESSEL TRIAL
Authors: Marco A. Costa, Jennifer Jones, F. James Fleischhauer, Wai-Fung Cheong, Hajime Kusano, Naim Farhat, Jin Wang, William Lombardi, Zhen Zhang, James Maddux, David Mego, Xiaolin Li, Louis Cannon, Kyoko Hattori, Malcolm T. Foster, Poornima Sood, Daniel Simon
Journal: Journal of the American College of Cardiology (2011)
Cyclophosphamide mechanism of action in preclinical tecemotide studies
Authors: Ken Hance, Robert Tighe, Jin Qi, William Hastings, Guozhong Qin, Bo Marelli, Hong Wang, Huakui Yu, Yanping Zhang, Xiaomei Xu, Wilson Guzman, Masie Wong, Giorgio Kradjian, Beatrice Brunkhorst, Helen Sabzevari, Yan Lan, Robert Hofmeister, Michael Wolf
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Tecemotide is a MUC1 antigen-specific therapeutic cancer vaccine. In phase III clinical studies, delivery of tecemotide is preceded by a single low dose of cyclophosphamide (CPA) to inhibit regulatory T cells (Tregs) and enhance the response to the tumor-associated antigen. Here,