tbuckley/cabot-search huggingface dataset:
Comparative Action of E.C.T. and of Pituitary Anterior Lobe Hormones on Thyroid Function
Authors: M. Reiss, R. E. Hemphill, R. Maggs, C. P. Haigh, J. M. Reiss
Journal: BMJ (1951)

Pickford, M., and Vogt, M. (1951). J. Physiol, 112, 133. Popa, G. T., and Fielding U. (1930). /. Anat., Lond., 65, 88. -(1933). Ibid., 67, 227. Richter, C. P. (1933). Amer. J. Physiol, 106, 80. Sawyer, C. H., Everett, J. W., and Markee, J. E. (1949). Endo crinology, 44, 218. Markee, J. E., and Townsend, B. F. (1949). Ibid., 44, 18. Sayers, G. (1950). Physiol. Rev., 30, 241. and Sayers, M. A. (1947). Endocrinology, 40, 265. -(1948). Rec. Progr. Horm. Res., 2, 81. Vogt, M. (1944). J. Physiol, 103, 317. (1951). Ibid. In press. Westman, A., and Jacobsohn, D. (1938a). Acta path, microbio!, scand., 15, 301. -(1938b). Acta obstet, gynec. scand., 18, 109. Wislocki, G. B. (1937). Anat. Rec, 69, 361. (1938). Res. Publ. Ass. nerv. ment. Dis., 17, 48. and King, L. S. (1936). Amer. J. Anat., 58, 421.
Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus.
Authors: D R McCance, D G Dyer, J A Dunn, K E Bailie, S R Thorpe, J W Baynes, T J Lyons
Journal: Journal of Clinical Investigation (1993)

Glycation, oxidation, and browning of proteins have all been implicated in the development of diabetic complications. We measured the initial Amadori adduct, fructoselysine (FL); two Maillard products, N epsilon-(carboxymethyl) lysine (CML) and pentosidine; and fluorescence (excitation = 328 nm, emission = 378 nm) in skin collagen from 39 type 1 diabetic patients (aged 41.5 +/- 15.3 [17-73] yr; duration of diabetes 17.9 +/- 11.5 [0-46] yr, [mean +/- SD, range]). The measurements were related to the presence of background (n = 9) or proliferative (n = 16) retinopathy; early nephropathy (24-h albumin excretion rate [AER24] > or = 20 micrograms/min; n = 9); and limited joint mobility (LJM; n = 20). FL, CML, pentosidine, and fluorescence increased progressively across diabetic retinopathy (P < 0.05, P < 0.001, P < 0.05, P < 0.01, respectively). FL, CML, pentosidine, and fluorescence were also elevated in patients with early nephropathy (P < 0.05, P < 0.001, P < 0.01, P < 0.01, respectively). There was no association with LJM. Controlling for age, sex, and duration of diabetes using logistic regression, FL and CML were independently associated with retinopathy (FL odds ratio (OR) = 1.06, 95% confidence interval (CI) = 1.01-1.12, P < 0.05; CML OR = 6.77, 95% CI = 1.33-34.56, P < 0.05) and with early nephropathy (FL OR = 1.05, 95% CI = 1.01-1.10, P < 0.05; CML OR = 13.44, 95% CI = 2.00-93.30, P < 0.01). The associations between fluorescence and retinopathy and between pentosidine and nephropathy approached significance (P = 0.05). These data show that FL and Maillard products in skin correlate with functional abnormalities in other tissues and suggest that protein glycation and oxidation (glycoxidation) may be implicated in the development of diabetic retinopathy and early nephropathy.
Exercise in pregnancy Uncomplicated diabetes is not a contraindication
Authors: M Brudenell, R Carbon
Journal: BMJ (1994)

place in the algorithm.The problem is that the proportion of urological and nephrological abnor- malities found has varied greatly in different reports.In a large series Mariani et al found that, of 883 patients with haematuria in whom a diagnosis was made, 319 had important or life threatening conditions.'Only 12 of these patients had renal disease that retrospectively had required renal biopsy.The ratio of risk to benefit and cost effectiveness were clearly less favourable for men and women below the age of 40.The only group that was singled out because of an extremely low risk of finding any life threatening condition, however, was women below the age of 40.In this group a different concept of evaluation may have to be applied.Obviously, urologists, who are used to carrying out flexible cystoscopy, find renal biopsy much more threatening and difficult.Nephrologists may take the opposite view.The algorithm that I proposed in my editorial is by no means definitive; an algorithm can never cover all aspects of the management of a disease.
Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment
Authors: Chi-Kuan Chen, Ching-Yao Yang, Kuo-Tai Hua, Ming-Chih Ho, Gunnar Johansson, Yung-Ming Jeng, Chiung-Nien Chen, Min-Wei Chen, Wei-Jiunn Lee, Jen-Liang Su, Tsung-Ching Lai, Chi-Chi Chou, Bing-Ching Ho, Chuan-Fa Chang, Po-Huang Lee, King-Jen Chang, Michael Hsiao, Ming-Tsan Lin, Min-Liang Kuo
Journal: Hepatology (2013)

Leukocyte cell-derived chemotoxin 2 (LECT2) has been shown to act as a tumor suppressor in hepatocellular carcinoma (HCC). However, the underlying mechanism has not yet been completely defined. Here, we employ a LECT2-affinity column plus liquid chromatography coupled with tandem mass spectrometry to identify LECT2-binding proteins and found that MET receptor strongly interacted with LECT2 protein. Despite the presence of hepatocyte growth factor, the LECT2 binding causes an antagonistic effect to MET receptor activation through recruitment of protein tyrosine phosphatase 1B. The antagonistic effect of LECT2 on MET activation also mainly contributes to the blockage of vascular invasion and metastasis of HCC. Furthermore, serial deletions and mutations of LECT2 showed that the HxGxD motif is primarily responsible for MET receptor binding and its antagonistic effects. Conclusion : These findings reveal a novel, specific inhibitory function of LECT2 in HCC by the direct binding and inactivation of MET, opening a potential avenue for treating MET-related liver cancer. (HEPATOLOGY 2014;59:974-985)
Mother at Fifty-two
Authors: M. Kirk Gooding
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New research in tuberous sclerosis.
Authors: D. W. Webb, J. P. Osborne
Journal: BMJ (1992)

report envisages-with completely new ways of delivering care-may actually prove harder than reshaping acute ser- vices and redirecting medical students.The biggest barrier, however, may be London itself.The report touches on the fact that health services cannot be seen in isolation: poverty, unreliable transport, violence, collapsed social services, rot- ten housing, and poor education all work against the sort of health service that the commission wants to see.Ministers have said that the political will exists to change London's health care, but they will need a lot of it to overcome the barriers and promote these radical -and untested - solutions.Unless he adopts completely the London Commission's ideas and analysis Tomlinson is unlikely to be as radical, and ministers might well be tempted by a smaller investment of political will.The daiiger is that anything less might not be enough.
THE TRUE ROLE OF DRUGS IN THE MANAGEMENT OF CONSUMPTIVES.
Authors: SOLOMON SOLIS-COHEN
Journal: JAMA (1901)

highly resistant to heat and to dflute acids and alkalis.4. The cell wall of the colon bacillus is digested by the prolonged action of artificial gastric juice, which does not alter the toxin. 5.The toxin as thus obtained is insoluble, or but slightly soluble, in dilute acid, but is slightly soluble in water and more readily in dilute alkalis.6.This toxin responds to the ordinary proteid reactions.7. The toxin, after being freed from the cell membrane, is not destroyed by being boiled.We will endeavor by further research to determine more defi- nitely the nature of this toxin and will extend our investigations to other bacteria.
The Cytological Diagnosis of Pulmonary Blastomycosis
Authors: Merlin L. Trumbull
Journal: JAMA (1981)

We reviewed 30 episodes of pulmonary blastomycosis among 29 patients to compare the methods of diagnosis and to assess the usefulness of cytological sputum examination. Complement fixation and skin tests were not helpful in diagnosis. Confirmation by culture of sputum or tissue required, on average, five weeks. We compared the cytological examination of bronchial secretions with that of microbiologic wet smears. The cytological technique yielded a positive diagnosis in 93% of patients and in 70% on the first specimen. Sixty-one percent of microbiologic wet smears proved positive, with 32% positive on the first specimen. The cytological findings were reported significantly sooner. In addition, cytological diagnosis of Blastomyces dermatitidis in sputum and bronchial washings of patients suspected of having a pulmonary cancer or infection reduced the time of diagnostic workup and the incidence of major surgery.
Systemic Lupus Erythematosus With Cutaneous Ulceration
Authors: Allan B. Kirsner
Journal: JAMA (1971)

A patient with systemic lupus erythematosus who had cutaneous ulceration as the initial complaint was followed up through three exacerbations and two remissions in ulcer size. A close correlation was found between serum complement titer, serum antinuclear antibody titer, corticosteroid dose, and ulcer size.
Long-term β-Carotene Supplementation and Risk of Type 2 Diabetes Mellitus
Authors: Simin Liu, Umed Ajani, Claudia Chae, Charles Hennekens, Julie E. Buring, JoAnn E. Manson
Journal: JAMA (1999)

Context Recent data suggest a protective role of carotenoids in the development of type 2 diabetes mellitus (DM), possibly via an antioxidant effect, but no randomized trial has directly assessed the efficacy of ␤-carotene to prevent DM.Objective To determine whether long-term ␤-carotene supplementation reduces the risk of developing type 2 DM.Design, Setting, and Participants A total of 22 071 healthy US male physicians aged 40 to 84 years in a randomized, double-blind, placebo-controlled trial, from 1982 to 1995.More than 99% of the participants had complete follow-up (median duration, 12 years).Intervention Subjects were randomly assigned to receive ␤-carotene (50 mg on alternate days) or placebo. Main Outcome Measure Incidence of type 2 DM.Results A total of 10 756 subjects were assigned to ␤-carotene and 10 712 to placebo.Incidence of type 2 DM did not differ between groups: 396 men in the ␤-carotene group and 402 men in the placebo group developed type 2 DM (relative risk, 0.98; 95% confidence interval, 0.85-1.12).The lack of association between ␤-carotene supplementation and incidence of type 2 DM persisted despite multivariate adjustment.There was no evidence of benefit when the period of risk was subdivided into years of follow-up or increasing duration of treatment. ConclusionIn this trial of apparently healthy men, supplementation with ␤-carotene for an average of 12 years had no effect on the risk of subsequent type 2 DM.
Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies.
Authors: S D Khare, H S Luthra, C S David
Journal: The Journal of Experimental Medicine (1995)

Human class I major histocompatibility complex allele HLA-B27 is associated with a group of human diseases called "spondyloarthropathies." Studies on transgenic rats expressing HLA-B27 and human beta 2-microglobulin have confirmed the role of HLA-B27 in disease pathogenesis. Here we report spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin (B27+ beta 2m-/-). In the absence of beta 2-microglobulin, B27+ beta 2m-/- animals do not express the HLA-B27 transgene on the cell surface and have a very low level of CD8+ T cells. Most of the B27+ beta 2m-/- male mice showed nail changes, hair loss, and swelling in paws, which leads to ankylosis. The symptoms occur only after the B27+ beta 2m-/- mice are transferred from the specific pathogen-free mouse colony. These results suggest that aberrant assembly, transport, and expression of the HLA-B27 molecule may predispose an individual for development of the disease when exposed to an appropriate environmental trigger.
Color Atlas and Textbook of Hematology
Authors: William R. Best
Journal: JAMA (1969)

The author, a pathologist, aims at the neophyte hematologist, be he physician or technician. Major emphasis is on the laboratory rather than the clinic. The color plates, one an excellent double fold-out on cell maturation, most of full-page size, appear mainly in three groupings through the book, and constitute a useful atlas on blood and marrow cells. A few plates are artist's drawings, and well done. More than 400 individual color photomicrographs are represented in other plates. Tincture, clarity, balance, and pertinence are generally good, occasionally poor. Characteristic cells are identified, but a few errors are seen. For example, a spherocyte in plate 24 is called an anisocyte, and ovalocytes in plate 21 are called spherocytes. Advantages, disadvantages, and problems associated with new, automated methods in hematology are considered in detail. There is a helpful chapter on quality control in the hematology laboratory. The technician will find good cookbook directions
Results of Diagnostic Pelviscopy in Cases of Chronic Recurrent Pelvic Disease
Authors: F. Buchholz, E. Philipp, K. Semm
Journal: Endoscopy (1976)

During the last two years we have performed diagnostic pelviscopy in 90 patients suffering from a syndrome of chronic repeated pelvic disease. In 44 patients extragenital endometriosis was diagnosed as the causing factor. In 15 cases we found wide-spread adhesions in the region of the lower pelvis after preceeding laparotomies. Only in 12 patients pelvic-alterations caused by chronic inflammatory processes of the adnexa with peritubal adhesions were discovered. As these results show extragenital endometriosis represents in far more cases as generally believed the cause of gynecological pains. We want to give special emphasis to the diagnosis and treatment of this disease.
A novel antitumour strategy using bidirectional autophagic vesicles accumulation via initiative induction and the terminal restraint of autophagic flux
Authors: Yang Wang, Xiaowei Tai, Li Zhang, Yayuan Liu, Huile Gao, Jiantao Chen, Kairong Shi, Qianyu Zhang, Zhirong Zhang, Qin He
Journal: Journal of Controlled Release (2014)
Metabolism of Atherosclerotic Tissue of Rabbit and Dog, with Special Reference to Esterase and Lipase
Authors: NELICIA MAIER, HENRY HAIMOVICI
Journal: Circulation Research (1965)

Esterase and lipase were studied in the aorta, liver, and serum of dogs and rabbits on an atherogenic diet. With the exception of dog serum, lipase was not present in any of the tissues studied. At a relatively early stage the atherosclerotic intima-media layer, separated at the cleavage plane, showed increased esterase activity in both animals. At later stages, a reverse trend was noted in the rabbit, whereas in the dog, the esterase activity remained markedly increased. No pre-atherosclerotic enzymatic changes were noted. The liver of both species showed increased esterase activity first and reversal to normal values later. In contrast, rabbit serum displayed no change for several months and decreased activity subsequently whereas in the dog, decreased esterase activity was noted throughout the administration of the atherogenic diet. Lipase activity in dog serum, which was unaffected for several months, decreased later. Our results expand previous findings with other arterial enzymes and indicate further that metabolic alterations of the arterial wall are associated with the development of atherosclerosis.
Monoclonal antibodies against the major allergen of <i>Plantago lanceolata</i> pollen, Pla l 1: affinity chromatography purification of the allergen and development of an ELISA method for Pla l 1 measurement
Authors: B. Calabozo, O. Duffort, J. A. Carpizo, D. Barber, F. Polo
Journal: Allergy (2001)

Background: Plantago lanceolata (English plantain) pollen is a relevant cause of pollinosis in temperate regions. The major allergen of this pollen, Pla l 1, is recognized by the specific IgE from more than 80% of plantain‐sensitive patients. It displays significant sequence homology with the major olive‐pollen allergen Ole e 1. The objective was to develop a monoclonal antibody‐based ELISA to quantify Pla l 1, and to assess the correlation of Pla l 1 content with the biologic activity of plantain pollen extracts. We also aimed to establish the specificity of the monoclonal antibodies against the potentially cross‐reactive allergen Ole e 1, and to investigate the presence of Pla l 1‐like proteins in psyllium and melon that have been reported to cross‐react with P. lanceolata pollen. Methods: After fusion of myeloma cells with spleen cells from a BALB/c mouse, two Pla l 1‐specific monoclonal antibodies secreting hybridomas were selected, and the antibodies characterized. One of them (2A10) was used as the capture antibody in an ELISA for Pla l 1 quantitation. An anti‐ P. lanceolata rabbit serum was used as the second antibody. Pla l 1 was purified by immunoaffinity chromatography and used as the standard in the assay. Results: The ELISA developed was highly reproducible and sensitive, with a detection limit of 0.1 ng/ml, and a practical working range of 0.4–12 ng/ml. The specificity was demonstrated against a large battery of allergens, including Ole e 1. The concentration of Pla l 1 was measured in 19 extracts of P. lanceolata pollen, and a good correlation was observed between the Pla l 1 content and the allergenic activity of the extracts. Pla l 1 was not detected in psyllium or melon extracts. Conclusions: The results prove the usefulness of the Pla l 1‐ELISA for the standardization of extracts of P. lanceolata pollen intended for clinical use.
Prisoners of Technology
Authors: Marcia Angell
Journal: New England Journal of Medicine (1990)

Life can now be sustained by medical technology under circumstances that just 15 to 20 years ago would have signified imminent death. This new power permits dramatic recoveries from some previously hopeless calamities. But, as with power in general, there is a dark side to it. Increasingly we find that life is being sustained indefinitely when there is no hope of recovery, simply because no one knows what else to do. Such a life may be filled with suffering, but sometimes it is devoid of anything — of pleasure, sensation, or comprehension.This is the state of Nancy Cruzan, a . . .
Funding for Research-Reply
Authors: Larry Culpepper
Journal: JAMA (1983)

In Reply.—  Regional sources of research funding included nonpharmaceutical sources that devote their resources to one geographic region of the country. These included funds specifically allocated for research by state government agencies, state health groups such as American Academy of Family Physicians state chapters, local heart, diabetes, and eye associations, local foundations, and industry. National nonfederal funding sources included similar nongovernmental groups with a national breadth of funding focus, including the Rockefeller Foundation, Kellogg Foundation, National Society for Prevention of Blindness, and the Reynolds Corporation.  Dr Bowman found only one research award from the top 60 private foundations, whereas I found several. This discrepancy may have several explanations. I surveyed all family medicine academic units regarding all research funding received during 1979. Responses included multiyear funding initiated in previous years and funding of collaborative projects in which the principal investigators belonged to other departments or had joint appointments. An additional
Psychotherapy and the Life History
Authors: Charles A. Dailey
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Psychotherapy and the Life History Subject Area: Psychiatry and Psychology Charles A. Dailey Charles A. Dailey Sudbury Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 239–242. https://doi.org/10.1159/000286873 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Charles A. Dailey; Psychotherapy and the Life History. Psychother Psychosom 31 December 1975; 25 (1-6): 239–242. https://doi.org/10.1159/000286873 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.