tbuckley/cabot-search huggingface dataset:
THE RESPONSE TO THE ADMINISTRATION OF AN ISOTONIC SODIUM CHLORIDE-LACTATE SOLUTION IN PATIENTS WITH ESSENTIAL HYPERTENSION
Authors: Solomon Papper, Joseph L. Belsky, Kenneth H. Bleifer
Journal: Journal of Clinical Investigation (1960)

Many studies indicate that patients with es- sential hypertension have a greater natriuretic re- sponse to rapidly administered sodium chloride solutions than have normotensive individuals (1-7).However, in most instances other fac- tors known to influence the rate of sodium ex- cretion in the normal subject such as diet, pos- ture, and time of day have not been rigidly con- trolled (8, 9).Dietary control is of particular importance in view of observations suggesting that patients with hypertension may habitually ingest more salt than do normotensive individuals (10-11).If this is indeed the case it might well be responsible for the enhanced response of the hypertensive patient to administered salt.The present report is concerned with a com- parison of the response of hypertensive and nor- motensive individuals to the intravenous administration of an "isotonic-balanced" salt solution under rigidly controlled conditions and at three dif- ferent levels of dietary salt ingestion.The re- sults indicate that patients with essential hypertension excrete the infused sodium load more rapidly than do normotensive individuals at each level of salt consumption. METHODSFour niormal Caucasian males aged 29 to 36 and 6 Caucasian patients aged 24 to 63 with essential hypertension were studied.The patients were selected on the basis of their maintaining a resting diastolic blood pres- sure of at least 100 mm Hg while hospitalized and con- suming a diet containing approximately 10 mEq of so- dium daily.Five of the 6 subjects were observed in this manner for 13 to 47 days prior to study, while Patient 8 received the low salt diet for 8 days prior to study.No patient had congestive heart failure, although no. 5 had
Immune complexes in Behcet's syndrome and recurrent oral ulceration.
Authors: B D Williams, T Lehner
Journal: BMJ (1977)

Seventeen patients with Behçet9s syndrome, 11 with recurrent oral ulceration, and eight controls were studied in an investigation of the part possibly played by immune complexes in the transition from focal oral ulceration to the multifocal syndrome. Changes in the distribution of C3 within the first peak of Sephadex G200 fractionated plasma were found in nine of the 17 patients with Behçet9s syndrome (55%), three of the 11 patients with recurrent oral ulcers, and none of eight controls. These findings provide indirect evidence that immune complexes are found in the plasma of these patients. Immune complexes were more common in patients with the neuro-ocular type of Behçet9s syndrome than in those with the mucocutaneous type, and in those with herpetiform ulcers than in those with major or minor aphthous ulcers. Immune complexes were also associated with active disease. These findings support the hypothesis that the formation of immune complexes is an important step in the pathogenesis of Behçet9s syndrome.
Pulmonary Carcinoma Metastasis to Great Toe
Authors: G. Richard Paul
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Malignant tumors rarely metastasize to the foot. Coley<sup>1</sup>collected only seven cases from the literature, two of which occurred in the phalanges but in none was the primary disease in the lung. Lichtenstein<sup>2</sup>cited one patient who had metastasis to bones of the foot, but in this patient the primary tumor was in the colon. However, Francis<sup>3</sup>reported five cases, one each with primary tumor in the breast, colon, kidney, prostate, and lung. A recent case report<sup>4</sup>discussed a renal cell carcinoma that metastasized to the great toe. Because of these few references in the literature, we are reporting this case of a patient who had carcinoma of the lung that metastasized to the great toe. <h3>Report of a Case:—</h3> A 55-year-old woman came to the Lahey Clinic Foundation in September 1967 with the chief complaint of pain that had been present for
Progression of Coronary Atherosclerosis
Authors: Floyd D. Loop
Journal: New England Journal of Medicine (1984)

Time, the severity of preexisting arterial stenosis, and coronary-artery surgery affect the progression of coronary atherosclerosis. As plaque formation worsens, the probability of acute obstruction increases significantly in medical and surgical patients.1 No clinical or laboratory risk factors consistently predict coronary arterial progression. The course of disease in arteries narrowed less than 50 per cent is less predictable but accounts for a substantial amount of progression documented by sequential coronary arteriography.2 Progression develops at nearly identical rates in unbypassed arteries in surgical patients and in medical patients with comparable lesions.3 The lowest rate of progression occurs in undiseased segments. The . . .
Isolation of<i>Chlamydia trachomatis</i>from Infant Lung Tissue
Authors: George T. Frommell, Frederic W. Bruhn, Joseph D. Schwartzman
Journal: New England Journal of Medicine (1977)

Chlamydia trachomatis causes inclusion conjunctivitis in newborns1 and is etiologically associated with urethritis in men2 and cervicitis in women.3 Recently, C. trachomatis has been identified as a respiratory colonist and possible pathogen in infants with pneumonia. In one report, the organism was recovered from a 7 1/2-week-old infant with conjunctivitis and pneumonia.4 Also, Beem and Saxon conducted a prospective study of 12 infants with a "distinctive pneumonia syndrome" in which C. trachomatis was isolated from conjunctiva, nasopharynx or trachea alone or in combination.5 However, their attempts to demonstrate chlamydia in tissue obtained from two open-lung biopsies were unsuccessful. In the . . .
Mutation-Linked Defective Interdomain Interactions Within Ryanodine Receptor Cause Aberrant Ca <sup>2+</sup> Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia
Authors: Takeshi Suetomi, Masafumi Yano, Hitoshi Uchinoumi, Masakazu Fukuda, Akihiro Hino, Makoto Ono, Xiaojuan Xu, Hiroki Tateishi, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Noriaki Ikemoto, Masunori Matsuzaki
Journal: Circulation (2011)

The molecular mechanism by which catecholaminergic polymorphic ventricular tachycardia is induced by single amino acid mutations within the cardiac ryanodine receptor (RyR2) remains elusive. In the present study, we investigated mutation-induced conformational defects of RyR2 using a knockin mouse model expressing the human catecholaminergic polymorphic ventricular tachycardia-associated RyR2 mutant (S2246L; serine to leucine mutation at the residue 2246).All knockin mice we examined produced ventricular tachycardia after exercise on a treadmill. cAMP-dependent increase in the frequency of Ca²⁺ sparks was more pronounced in saponin-permeabilized knockin cardiomyocytes than in wild-type cardiomyocytes. Site-directed fluorescent labeling and quartz microbalance assays of the specific binding of DP2246 (a peptide corresponding to the 2232 to 2266 region: the 2246 domain) showed that DP2246 binds with the K201-binding sequence of RyR2 (1741 to 2270). Introduction of S2246L mutation into the DP2246 increased the affinity of peptide binding. Fluorescence quench assays of interdomain interactions within RyR2 showed that tight interaction of the 2246 domain/K201-binding domain is coupled with domain unzipping of the N-terminal (1 to 600)/central (2000 to 2500) domain pair in an allosteric manner. Dantrolene corrected the mutation-caused domain unzipping of the domain switch and stopped the exercise-induced ventricular tachycardia.The catecholaminergic polymorphic ventricular tachycardia-linked mutation of RyR2, S2246L, causes an abnormally tight local subdomain-subdomain interaction within the central domain involving the mutation site, which induces defective interaction between the N-terminal and central domains. This results in an erroneous activation of Ca²⁺ channel in a diastolic state reflecting on the increased Ca²⁺ spark frequency, which then leads to lethal arrhythmia.
Left ventricular remodeling early after aortic valve replacement: differential effects on diastolic function in aortic valve stenosis and aortic regurgitation
Authors: Hildo J Lamb, Hugo P Beyerbacht, Albert de Roos, Arnoud van der Laarse, Hubert W Vliegen, Ferre Leujes, Jeroen J Bax, Ernst E van der Wall
Journal: Journal of the American College of Cardiology (2002)
Prednisolone inhibits hyperosmolarity-induced expression of MCP-1 via NF-κB in peritoneal mesothelial cells
Authors: H. Matsuo, M. Tamura, N. Kabashima, R. Serino, M. Tokunaga, T. Shibata, M. Matsumoto, M. Aijima, S. Oikawa, H. Anai, Y. Nakashima
Journal: Kidney International (2006)
Physical exercise and blood flow properties.
Authors: G Ciuffetti, M Mercuri, R Lombardini, U Milia, E Mannarino
Journal: British Journal of Sports Medicine (1990)

In 46 executive level managers at risk for cardiovascular disease, whole blood filterability through five micron pore Nuclepore filters was monitored using a constant flow positive pressure system before and after treadmill exercise and compared to our laboratory standard. Our results show regular exercise compensates not only for the potential damage risk factors represent but also for the physical stress provoked by vigorous exercise.
FUNCTIONAL TESTS OF HEARING: SOME OF THE PRINCIPLES ON WHICH THEY ARE BASED.
Authors: WILLIAM LINCOLN BALLENGER
Journal: JAMA (1903)

The object of this paper is to call attention to the value of some of the functional tests of hearing and to the principles on which they are based. Wm. H. Thompson has recently made the significant statement that a knowledge of diseases of the ear is of more value to the general practitioner than that of all the other special senses put together. This being true, a knowledge of the more accurate methods of diagnosis and prognosis becomes a question of prime importance. The functional tests of hearing are of greatest value in that large and oftentimes perplexing group of diseases of the non-suppurative type which affect the middle ear and labyrinth. No one doing ear work can claim to be abreast of the times if he does not have an intimate and comprehensive knowledge of the principles underlying these tests. They are to the otologist what the ophthalmoscope
Preliminary Sibpair Linkage Analysis of Percent Mammographic Density
Authors: C. M. Vachon, R. A. King, L. D. Atwood, C. C. Kuni, T. A. Sellers
Journal: JNCI Journal of the National Cancer Institute (1999)

Interindividual variability in mam-mographic breast density has beenshown to be a major independent riskfactor for breast cancer (1). There is evi-dence for a genetic influence on breastdensity (2,3). In the Journal (4), we re-cently reported a segregation analysisof breast density performed on 1370women from 258 families in the Minne-sota Breast Cancer Family Cohort (5).After adjustment for eight epidemio-logic risk factors, percent breast densitywas consistent with mendelian modelsof inheritance (4). To provide additionalevidence for a major gene influence onbreast density, we report results from apreliminary sibpair linkage analysis on asample of women from the same largebreast cancer family cohort.The sibpairs used in the linkageanalysis were selected from a conve-nience sample of women from the fam-ily study who participated in the veni-puncture, mammogram, and telephoneinterview components of the BreastCancer Family Cohort (5). Women withprior breast cancer were not eligible forthis analysis to reduce potential geneticheterogeneity. Written informed consentwas obtained from the subjects in thisstudy.The fraction of the mammogram oc-cupied by fibroglandular elements wasestimated visually by a radiologist expe-rienced in mammography (C. C. Kuni).Density estimation was made in 5% in-crements from a video display of the leftmediolateral oblique view; the right me-diolateral oblique view was used if theleft was unavailable.Because there are no obvious candi-date genes for breast density, we per-formed a genome screen using a set ofhighly polymorphic short-tandem repeatpolymorphism markers spaced approxi-mately 30 cM apart. Evidence for link-age was determined with both two-point[SIBPAL in SAGE (6)] and multipoint[MAPMAKER/SIBS (7)] linkage analy-ses on both the unadjusted breast densitytrait and the trait adjusted for the in-fluence of nongenetic covariates. TheSIBPAL test for linkage is a test ofnegative slope (i.e., H
Impact of Early Post-exercise Myocardial Redistribution of TI-201 on SPECT Imaging
Authors: ARNOLD F. JACOBSON, DONALD E. TOW, J ANTHONY PARKER, WALTER H. WILLIAMS, BESHIR JAZMATI, EDWARD FOLLAND
Journal: Clinical Nuclear Medicine (1991)

In a series of 62 male patients undergoing exercise TI-201 SPECT myocardial scintigraphy, planar 45° LAO images were acquired before (2–5 minutes postinjection, P1) and after (35 minutes postinjection, P2) the initial SPECT study in order to identify those patients with redistribution during the first 30 minutes after exercise. Consensus interpretation by four readers identified early redistribution (between P1 and P2) in 11 patients (18%), rated major (change of > 1.5 scoring unit) in five and minor (change of 1–1.5 scoring unit) in six. Only one patient (2%) showed major early redistribution that could not be appreciated on corresponding SPECT images. In this preliminary investigation, early thallium redistribution sufficient to affect identification of significant exercise-induced ischemia on SPECT imaging was infrequent and of limited clinical importance.
A market for gastric NOTES closure: which path should we take?
Authors: A. Fritscher-Ravens
Journal: Endoscopy (2009)

The new approach of natural-orifice transluminal endoscopic surgery (NOTES) has excited surgeons and gastroenterologists alike. Not only is the method of passing through the gut into the peritoneal cavity with a flexible endoscope exciting, but the development of the devices necessary to work in the newly conquered space is stimulating likewise. A NOTES incision closure device is one of the most important new developments to look forward to. It needs to be a very reliable tool since as soon as a potential iatrogenic complication has been created, a robust solution to fix it should be the first requirement. Some variations of many novel devices and techniques are described in this issue of Endoscopy [1].
Going After the Money
Authors: Ashish K. Jha
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor
Authors: Hung-Yun Lin, I-Chen Yu, Ruey-Shen Wang, Yei-Tsung Chen, Ning-Chun Liu, Saleh Altuwaijri, Cheng-Lung Hsu, Wen-Lung Ma, Jenny Jokinen, Janet D. Sparks, Shuyuan Yeh, Chawnshang Chang
Journal: Hepatology (2008)

Early studies demonstrated that whole-body androgen receptor (AR)–knockout mice with hypogonadism exhibit insulin resistance. However, details about the mechanisms underlying how androgen/AR signaling regulates insulin sensitivity in individual organs remain unclear. We therefore generated hepatic AR-knockout (H-AR−/y) mice and found that male H-AR−/y mice, but not female H-AR−/− mice, fed a high-fat diet developed hepatic steatosis and insulin resistance, and aging male H-AR−/y mice fed chow exhibited moderate hepatic steatosis. We hypothesized that increased hepatic steatosis in obese male H-AR−/y mice resulted from decreased fatty acid β-oxidation, increased de novo lipid synthesis arising from decreased PPARα, increased sterol regulatory element binding protein 1c, and associated changes in target gene expression. Reduced insulin sensitivity in fat-fed H-AR−/y mice was associated with decreased phosphoinositide-3 kinase activity and increased phosphenolpyruvate carboxykinase expression and correlated with increased protein-tyrosine phosphatase 1B expression. Conclusion: Together, our results suggest that hepatic AR may play a vital role in preventing the development of insulin resistance and hepatic steatosis. AR agonists that specifically target hepatic AR might be developed to provide a better strategy for treatment of metabolic syndrome in men.
Noninvasive Evaluation of Human Circulation: Clinical, Clinicopharmacological and Data Processing Aspects
Authors: David H. Spodick
Journal: JAMA (1977)

American physicians have been the poorer for their lack of acquaintance with much of the newer foreign work. This new book by an internationally distinguished cardiologist summarizes in flawless English his valuable contributions, which have been known, in the United States at least, only to connoisseurs. Although Dr Simonyi has used fairly sophisticated instruments and statistics to prove his methods, the information is derived from essentially simple carotid pulse curve derivatives, which could be recorded even on an office ECG. The text briefly explains his methods and demonstrates the practical versatility of the carotid derivative in diagnosing cardiac lesions like aortic valve disease, congestive heart failure, and hypertension and in measuring systolic time intervals and responses to physiologic challenges like exercise and pharmacologic challenges like catecholamine stimulation and propranolol blockade of β-adrenergic responses. This is a solid contribution to the theory and practice of noninvasive cardiology.
Doctors Awarded the Congressional Medal of Honor
Authors: Frank B. Berry
Journal: JAMA (1963)

To the Editor:  —I was extremely interested in the fine article by Dr. R. J. Popkin, Doctors Awarded the Congressional Medal of  in the Dec 29 issue ofThe Journal( 182: 1319). A recently issued book, Above and Beyond by Joseph L. Schott (New York. Putnam & Sons, 1962) is a history of the Congressional Medal of Honor and lists all who have received it. The medal was first authorized in 1863 on a recommendation to Congress by the Secretary of the Navy and followed 6 mo later by authorization to the Army. At first, Secretary Stanton was hesitant because of General Scott's objections to medals. In the early days the medal was awarded for all sorts of acts, courageous and some not so courageous. In fact, the last award of a Civil War medal occurred in 1917.  An interesting fact that Dr. Popkin fails to mention was that
A Pit-1 binding site in the human renin gene promoter stimulates activity in pituitary, placental and juxtaglomerular cells
Authors: Daniel F. Catanzaro, Jidong Sun, Matthew T. Gilbert, Yan Yan, Tom Black, Curt Sigmund, Kenneth W. Gross
Journal: Kidney International (1994)

One of the principal aims of our research is to determine the mechanisms which direct renin gene expression to different sites. We recently demonstrated that human renin (hRen) 5'-flanking DNA sequences -148 +/- 11 can drive the transient expression of a linked luciferase reporter gene transfected into pituitary GC cells. This activity was found to be dependent on the binding of Pit-1 to a site approximately 70 bp upstream from the transcription start site. Pit-1 is a pituitary-specific transcription factor which is involved in directing the cell-specific expression of growth hormone (GH) and prolactin (PRL) gene expression to somatotrope and lactotrope cells of the anterior pituitary. Thus, Pit-1 may be play a role in directing the expression of renin to primate lactotrope cells. Renin promoter-driven luciferase or CAT hybrid genes were found to be expressed following transfection into primary, or early passage cell cultures of placental chorionic membranes, and the renin-secreting renal tumor cell line As4.1. As with GC cells, deletion or mutagenesis of the Pit-1 site reduced activity several-fold in both placental and renal cells. These results suggest that members of the POU family of transcription factors, or some other closely related group such as the Hox proteins, participate in directing renin gene expression to placental and juxtaglomerular cells.
Depressive Symptoms and Stressful Life Events Predict Metabolic Syndrome Among Middle-Aged Women
Authors: Katri Räikkönen, Karen A. Matthews, Lewis H. Kuller
Journal: Diabetes Care (2007)

We evaluated whether psychosocial factors that are related to cardiovascular disease and type 2 diabetes predict prospectively the risk for the metabolic syndrome using the different clinical criteria available for defining the syndrome.Women were enrolled in a population-based prospective cohort study called the Healthy Women Study and were followed for an average of 15 years after baseline. Metabolic syndrome was defined via the World Health Organization, the National Cholesterol Education Program Adult Treatment Panel III, and the International Diabetes Foundation clinical criteria.Among women who did not have the metabolic syndrome at the baseline, the risk for the metabolic syndrome defined in multiple ways varied from 1.21- to 2.12-fold ([95% CI 1.00-4.25], P < 0.05) for more severe depressive symptoms or very stressful life event(s). These associations were largely the same, regardless of the clinical criteria used to define the metabolic syndrome. Those who at the baseline reported feeling frequently and intensely angry, tense, or stressed also had an increased risk for developing the metabolic syndrome at least by one definition (relative risk 1.19-1.66 [1.00-2.39]).These are the first data to demonstrate that psychosocial factors predict the risk for developing the metabolic syndrome by multiple definitions. Psychosocial factors may play a causal role in the chain of events leading to the metabolic syndrome.