tbuckley/cabot-search huggingface dataset:
Forty-Three Dialyses in a Community Hospital
Authors: William D. Loeser
Journal: JAMA (1965)

Adherence to the team concept enabled physicians to accomplish 43 dialyses in a community hospital, sharing a work load which would have been difficult for an individual physician to shoulder. During a four-year span, six categories of patients were dialyzed, namely those with (1) anuria or severe oliguria, (2) drug poisoning, (3) anasarca or pulmonary edema, or both, (4) retroperitoneal extravasation of urine, (5) azotemia, and (6) those to be operated on. Results were especially gratifying in categories 1 and 2. When patients with the admitting diagnosis of azotemia were dialyzed, final results and diagnoses were sometimes at variance with initial expectations. Temporary improvement in a patient having retroperitoneal extravasation of urine and delay in institution of surgical repair suggests that application of dialysis in this medical emergency merits consideration and further study.
MEASURES CALCULATED TO MODIFY ACUTE INFLAMMATIONS OF THE RESPIRATORY TRACT.
Authors: H. B. SEARS
Journal: JAMA (1895)

No single remedy or measure can always be relied upon to afford relief in any acute disorder, as the disease itself is often but a climax in a pathologic process, the divergent lines from which, radiate to a series of inherited or acquired causes; the most important of which must receive consideration of him who would stay the process of disease or assist nature in restoring to health. Undoubtedly there are many measures utilized in therapeutics, identical in effect; also more than one way by which a pathologic process may be turned to a healthful issue. We find ourselves to-day confronted with quite a number of methods for treating acute respiratory troubles; each of which, undoubtedly, possesses merits peculiar to itself and well adapted to meet certain indications which arise in these affections; but that any one remedy or means can fulfill all the indications or be applicable in every
Arthur Hail Keeney, MD, DSc, DSc(Hon), 76
Authors: Frank W. Newell
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship of education to major risk factors and death from coronary heart disease, cardiovascular diseases and all causes, Findings of three Chicago epidemiologic studies.
Authors: K Liu, L B Cedres, J Stamler, A Dyer, R Stamler, S Nanas, D M Berkson, O Paul, M Lepper, H A Lindberg, J Marquardt, E Stevens, J A Schoenberger, R B Shekelle, P Collette, S Shekelle, D Garside
Journal: Circulation (1982)
European Antibiotic Awareness Day and access to antibiotics
Authors: N. M. Brown, L. J. V. Piddock, M. S. Dryden
Journal: BMJ (2012)

The fifth annual European Antibiotic Awareness Day (EAAD) was on 18 November 2012.1 It aimed to promote knowledge about appropriate use of antibiotics and reduce the emergence of drug resistance and other “collateral damage” as a result of antibiotic exposure.2 Prudent antibiotic use is emphasised within the recent Department of Health antibiotic stewardship strategy.3

Antibiotics differ …
Book: Promoting Community Health: From Pholela to Jerusalem
Authors: J. Horder
Journal: BMJ (2000)

Sydney Kark, Emily Kark Witwatersrand University Press (available from Africa Book Centre) info@africabookcentre.com), £14.95, pp 254 ISBN 1 86814 316 3 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Primary care groups and trusts have recently been set up in Britain to make health services more responsive to the needs of defined local communities. The Commission for Health Improvement challenges them and each primary care team to improve health as well as to deliver responsive care. Are there readily available models from which we might learn? In South Africa in 1940 Sydney … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
What Do Regional Variations in the Rates of Hospitalization of Children Really Mean?
Authors: Paul H. Wise, Leon Eisenberg
Journal: New England Journal of Medicine (1989)

Regional variations in the use of hospitalization are a fruitful research area pioneered by Wennberg.1 In this issue of the Journal, Perrin and his coworkers2 report important differences in the rates of hospitalization of children in three metropolitan areas — Boston, New Haven, and Rochester (New York) — with the rates in Boston highest and in Rochester lowest. Their study documents large disparities for a range of medical conditions, particularly those that allow the clinician considerable discretion. For surgical conditions, in contrast, variations were smaller and less consistent. The disparities were not explained by differences in the availability of . . .
Cephalosporin and Aminoglycoside Nephrotoxic Interaction
Authors: WILLIAM H. GREEN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 March 1979Cephalosporin and Aminoglycoside Nephrotoxic InteractionWILLIAM H. GREEN, M.D.WILLIAM H. GREEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-435_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the recent succinct review of cefazolin by Quintiliani and Nightingale (1), they briefly mention the possible interaction of cephalosporins and aminoglycosides, notably cephalothin and gentamicin, in causing nephrotoxicity. Although reliable data for cefazolin plus aminoglycosides are too limited for definitive evaluation, this interaction deserves greater emphasis than they have given it. The reference cited by Quintilliani and Nightingale, that of Bobrow and associates (2) was indeed one of the early reports of catastrophic renal failure associated with cephalothin and gentamicin administration. The anecdotal nature of such reports, the frequent coexistence of serious underlying disorders and other...References1. QUINTILLIANINIGHTINGALE RC: Cefazolin. Ann Intern Med 89(Part 1):650-656, 1978 LinkGoogle Scholar2. BOBROWJAFFEYOUNG SER: Anuria and acute tubular necrosis associated with gentamicin and cephalothin. JAMA 222:1546-1547, 1972 CrossrefMedlineGoogle Scholar3. KLASTERSKYHENSGENSDEBUSSCHER JCL: Empiric therapy for cancer patients: comparative study of ticarcillin-tobramycin, ticarcillin-cephalothin, and cephalothin-tobramycin. Antimicrob Agents Chemother 7:640-645, 1975 CrossrefMedlineGoogle Scholar4. : Three antibiotic regimens in the treatment of infection in febrile granulocytopenic patients with cancer. J Infect Dis 137:14-29, 1978 CrossrefMedlineGoogle Scholar5. WADESMITHPETTYLIPSKYCONRADELLNERLIETMAN JCBJGJP: Cephalothin plus an aminoglycoside is more nephrotoxic than methicillin plus an aminoglycoside. Lancet 2:604-606, 1978 CrossrefMedlineGoogle Scholar6. KLASTERSKYDEBUSSCHERWEERTS-RUHLPREVOST JLDJ: Carbenicillin, cefazolin, and amikacin as an empiric therapy for febrile granulocytopenic cancer patients. Cancer Treat Rep 61:1433-1439, 1977 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIncreased nephrotoxicity of gentamicin in pyelonephritic ratsDifferent Forms of Ischemic/ Toxic Acute Renal Failure in HumansPenicillins, cephalosporins and tetracyclines 1 March 1979Volume 90, Issue 3Page: 435-436KeywordsRenal failure Issue Published: 1 March 1979 PDF downloadLoading ...
COMPARISON OF CARDIOVASCULAR EVENTS BETWEEN PATIENTS ACHIEVING LOW-DENSITY LIPOPROTEIN PARTICLE TARGETS AND PATIENTS ACHIEVING LOW-DENSITY LIPOPROTEIN CHOLESTEROL TARGETS
Authors: Terry A. Jacobson, Michael Grabner, Rajeshwari Punekar, Ralph A. Quimbo, Mark Cziraky, Deborah Winegar, Peter Toth
Journal: Journal of the American College of Cardiology (2014)
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival
Authors: Michail S. Lionakis, Muthulekha Swamydas, Brett G. Fischer, Theo S. Plantinga, Melissa D. Johnson, Martin Jaeger, Nathaniel M. Green, Andrius Masedunskas, Roberto Weigert, Constantinos Mikelis, Wuzhou Wan, Chyi-Chia Richard Lee, Jean K. Lim, Aymeric Rivollier, John C. Yang, Greg M. Laird, Robert T. Wheeler, Barbara D. Alexander, John R. Perfect, Ji-Liang Gao, Bart-Jan Kullberg, Mihai G. Netea, Philip M. Murphy
Journal: Journal of Clinical Investigation (2013)

Systemic Candida albicans infection causes high morbidity and mortality and is associated with neutropenia; however, the roles of other innate immune cells in pathogenesis are poorly defined. Here, using a mouse model of systemic candidiasis, we found that resident macrophages accumulated in the kidney, the main target organ of infection, and formed direct contacts with the fungus in vivo mainly within the first few hours after infection. Macrophage accumulation and contact with Candida were both markedly reduced in mice lacking chemokine receptor CX3CR1, which was found almost exclusively on resident macrophages in uninfected kidneys. Infected Cx3cr1–/– mice uniformly succumbed to Candida-induced renal failure, but exhibited clearance of the fungus in all other organs tested. Renal macrophage deficiency in infected Cx3cr1–/– mice was due to reduced macrophage survival, not impaired proliferation, trafficking, or differentiation. In humans, the dysfunctional CX3CR1 allele CX3CR1-M280 was associated with increased risk of systemic candidiasis. Together, these data indicate that CX3CR1-mediated renal resident macrophage survival is a critical innate mechanism of early fungal control that influences host survival in systemic candidiasis.
Development and validation of a predictive mortality risk score from a European hemodialysis cohort
Authors: Jürgen Floege, Iain A. Gillespie, Florian Kronenberg, Stefan D. Anker, Ioanna Gioni, Sharon Richards, Ronald L. Pisoni, Bruce M. Robinson, Daniele Marcelli, Marc Froissart, Kai-Uwe Eckardt
Journal: Kidney International (2015)

Although mortality risk scores for chronic hemodialysis (HD) patients should have an important role in clinical decision-making, those currently available have limited applicability, robustness, and generalizability. Here we applied a modified Framingham Heart Study approach to derive 1- and 2-year all-cause mortality risk scores using a 11,508 European incident HD patient database (AROii) recruited between 2007 and 2009. This scoring model was validated externally using similar-sized Dialysis Outcomes and Practice Patterns Survey (DOPPS) data. For AROii, the observed 1- and 2-year mortality rates were 13.0 (95% confidence interval (CI; 12.3-13.8)) and 11.2 (10.4-12.1)/100 patient years, respectively. Increasing age, low body mass index, history of cardiovascular disease or cancer, and use of a vascular access catheter during baseline were consistent predictors of mortality. Among baseline laboratory markers, hemoglobin, ferritin, C-reactive protein, serum albumin, and creatinine predicted death within 1 and 2 years. When applied to the DOPPS population, the predictive risk score models were highly discriminatory, and generalizability remained high when restricted by incidence/prevalence and geographic location (C-statistics 0.68-0.79). This new model offers improved predictive power over age/comorbidity-based models and also predicted early mortality (C-statistic 0.71). Our new model delivers a robust and reproducible mortality risk score, based on readily available clinical and laboratory data.
RANDOMIZED, PARTIAL BLIND STUDY OF THE PHARMACODYNAMICS, PHARMACOKINETICS AND SAFETY OF MULTIPLE SUBCUTANEOUS DOSES OF ALIROCUMAB, A FULLY HUMAN MONOCLONAL ANTIBODY TO PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, ADMINISTERED EVERY 4 WEEKS ALONE OR IN COMBINATION WITH EZETIMIBE OR FENOFIBRATE IN HEALTHY SUBJECTS
Authors: Jacques Rey, Franck Poitiers, Tobias Paehler, Aurelie Brunet, Jean-Louis Pinquier, Corinne Hanotin, Bill Sasiela
Journal: Journal of the American College of Cardiology (2014)
Evaluation of Psychotherapies and Osgood&amp;rsquo;s Semantic Differential
Authors: E. Gilli&eacute;ron, J. Bovet
Journal: Psychotherapy and Psychosomatics (1980)

Setting up a semantic differential according to Osgood for evaluating analytical psychotherapies: a selection of scales and inducive words plus a factor analysis based on answers obtained from two test groups--the one composed of ambulatory psychiatric patients, the other composed of normal individuals. Preliminary validity tests of the results for applicability in clinical situations: examples of individual semantic configurations reflecting in a plausible manner certain clinical characteristics; comparison of the configurations of a group of neurotics with those of a group of schizophrenics; example of the evolution of one configuration during the period of psychoanalytical treatment. These first tests led us to believe that the semantic differential could contribute effectively to the evaluation of psychotherapies.
Alkaline phosphatase activity and localization during the murine hair cycle
Authors: B.K. HANDJISKI, S. EICHMULLER, U. HOFMANN, B.M. CZARNETZKI, R. PAUS
Journal: British Journal of Dermatology (1994)

Journal Article Alkaline phosphatase activity and localization during the murine hair cycle Get access B.K. HANDJISKI, B.K. HANDJISKI Department of Dermatology. University Hospital Rudolf Virchow, Freie Universität Berlin D‐13344 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar S. EICHMÜLLER, S. EICHMÜLLER Department of Dermatology. University Hospital Rudolf Virchow, Freie Universität Berlin D‐13344 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar U. HOFMANN, U. HOFMANN Department of Dermatology. University Hospital Rudolf Virchow, Freie Universität Berlin D‐13344 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar B.M. CZARNETZKI, B.M. CZARNETZKI Department of Dermatology. University Hospital Rudolf Virchow, Freie Universität Berlin D‐13344 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar R. PAUS R. PAUS Department of Dermatology. University Hospital Rudolf Virchow, Freie Universität Berlin D‐13344 Berlin, Germany *Correspondence: Dr R.Paus. Hautklinik, UKRV. FU Berlin. Augustenburger Pl.l, D‐13344 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 3, 1 September 1994, Pages 303–310, https://doi.org/10.1111/j.1365-2133.1994.tb08515.x Published: 01 September 1994 Article history Accepted: 31 January 1994 Published: 01 September 1994
Hitoshi Oshitani: watching out for an influenza pandemic
Authors: Ned Stafford
Journal: The Lancet (2005)

Hitoshi Oshitani, the person in Asia responsible for sounding global alarm bells at the first sign of a pandemic strain of influenza, admits feeling the strain of his job. "It is a very stressful situation. I'm under tremendous pressure." The stakes are high. Most experts agree that the emergence of a pandemic virus is not a question of if, but of when. Estimates range from 2 million to 150 million deaths worldwide. Early detection and containment measures could possibly save millions of lives. Oshitani, regional adviser in Communicable Disease Surveillance and Response at the WHO's Western Pacific regional office in Manila, says: "Our main goal is the early detection of the outbreak.
The Geriatrician's Lab (Yellow)
Authors: David B. Reuben
Journal: Annals of Internal Medicine (2008)

On Being a Doctor18 March 2008The Geriatrician's Lab (Yellow)David B. Reuben, MDDavid B. Reuben, MDFrom David Geffen School of Medicine, University of California, Los Angeles, CA 90095.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-6-200803180-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Every man has 5 dogs—so said Saul Bellow. Jenna was my fourth. I left my first 2 dogs, Sugar and Molly, when they were still in their prime. In Sugar's case, I moved out of state as a teenager and she was relocated to a farm in Missouri … or so I was told. Molly stayed with a former lover when I was asked to leave. Martha, my third dog, was the perfect canine. Indeed, she sparked a generation of my trainees and colleagues to adopt dogs. Mostly Labrador retriever, Martha had the right size, the right temperament, and the ... Author, Article, and Disclosure InformationAuthors: David B. Reuben, MDAffiliations: From David Geffen School of Medicine, University of California, Los Angeles, CA 90095.Corresponding Author: David B. Reuben, MD, Department of Medicine, Division of Geriatrics, University of California, Los Angeles, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095; e-mail, [email protected]ucla.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReturning from the Total Institution to a Home Environment: A Journey for Birthing and Dying 18 March 2008Volume 148, Issue 6Page: 480-481KeywordsFoodForecastingHospitalizationsNutrientsRenal failureShouldersSmellSurgeryUrinary incontinenceUrination ePublished: 18 March 2008 Issue Published: 18 March 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
John Eric Somerville Scott
Authors: A. Craft, S. Court
Journal: BMJ (2012)

John Eric Somerville Scott was brought up in Africa as his father was in the colonial medical service, although he later settled in Penzance as a general practitioner. He was proud of his forbears, his grandfather and uncle were diplomats in Shanghai, and he traced his roots back to the Scottish borders

His early childhood was not particularly happy, and he lost a sister after what he later thought to be an unnecessary operation to straighten her legs

He was educated at Upcot House and Sherborne, followed by Queens College Cambridge. At Cambridge during the war, he was on an accelerated training programme that filled him with a real sense of purpose and energy to …
Benefits of blockers in chronic obstructive pulmonary disease and heart failure
Authors: B. Creagh-Brown
Journal: BMJ (2014)

Williams and Oakeshott caution against the use of the β blocker bisoprolol for chronic heart failure in patients with severe asthma or chronic obstructive pulmonary disease (COPD).1 This recommendation is somewhat contentious. Patients with COPD often have cardiac comorbidities, including chronic heart failure (~20% of patients2), and in one large study of patients with COPD, 27% of deaths were attributable to cardiac causes.3 Selective β blockers such as bisoprolol have been shown to be safe in COPD.4 5 Moreover, in addition to the beneficial effects on outcomes relating to heart failure, there is mounting evidence that β blockade may also improve outcomes from COPD.6
Pneumococcal cross infection in hospital.
Authors: A J Davies, P M Hawkey, R A Simpson, K M O'Connor
Journal: BMJ (1984)

Pneumococcal cross infection in hospitalThe mortality associated with pneumococcal infection has been reduced with chemotherapy and modern supportive care, though pneumococcal bacteraemia in elderly patients still carries a poor prognosis.The ready availability of penicillin and other antibiotics that are effective against pneumococci may have distracted attention from cross infection among patients.'Sinigar H.The variability in virulence of the pneumococcus.
Effect of chloramphenicol on colony formation from erythrocytic precursors
Authors: Hiroshi Hara, Masatoshi Kohsaki, Kohji Noguchi, Kyoyasu Nagai
Journal: American Journal of Hematology (1978)

Abstract In the present experiments, we compare the behavior of erythropoietic precursors and granulocytic precurosors exposed to chloramphenicol. Subcutaneous injection of 20 mg of chloramphenicol sodium succinate on five successive days induced a reduction in the number of erythrocytic colony‐forming units (CFU‐E) and erythropoietic burst‐forming units (BFU‐E) in murine marrow and spleen, while no change in number of granulocytic precursors (CFU‐C) in murine hemopoietic organs was observed. In vitro studies demonstrated concentration‐dependent inhibition of chloramphenicol or chloramphenicol sodium succinate in the colony formation of all these precursors from murine and human bone marrow. However, erythropoietic burst formation of murine and human BFU‐E was completely suppressed by the addition of chloramphenicol or chloramphenicol sodium succinate to the culture medium at therapeutic concentrations (20‐40 μ/ml). From the present results, it can be concluded that the reduced number of BFU‐E in mice after injection of chloramphenicol sodium succinate resulted from the selective toxicity of chloramphenicol to BFU‐E at therapeutic con centrations.
Left Ventricular Diastolic Pressure Elevation Consequent to Pulmonary Stenosis
Authors: WALTER H. HERBERT, EDWARD YELLIN
Journal: Circulation (1969)

Patients with mild pulmonary stenosis, predominant mitral stenosis, or aortic valvular disease were studied by standard catheterization technics to determine the effect of their lesions upon both the ipsilateral and contralateral ventricles. The study suggested (1) that left heart lesions which produce an elevation of left ventricular end-diastolic pressure (LVEDP) do not necessarily cause an abnormal rise in diastolic pressure in the contralateral ventricle, (2) that eccentric right ventricular hypertrophy by definition without septal involvement may produce elevated right ventricular end-diastolic pressure without affecting LVEDP, and (3) that concentric right ventricular hypertrophy appears to effect an elevation in end-diastolic pressure in both the ipsilateral and contralateral ventricles. Possible mechanisms related to the biventricular architecture are discussed.