tbuckley/cabot-search huggingface dataset:
Transformation of bilineal hybrid acute leukemia to acute lymphoid leukemia: A case report with serial analyses of cytogenetics and gene rearrangement
Authors: I. Jinnai, S. Kusumoto, Z. Shiomi, M. Bessho, M. Saitoh, K. Hirashima, M. Minamihisamatsu, T. Kamiyama, K. Takase
Journal: American Journal of Hematology (1990)

Abstract A 17‐year‐old male with bilineal hybrid acute leukemia is described. Two‐color flow cytometric analysis of blast surface phenotype revealed that there were two groups of blasts which showed either CD 10 + CD 19 + CD 13 − CD 33 − or CD 10 − CD 19 − CD 13 + CD 33 + , but not both. He developed a complete remission by treatment with vincristine, prednisolone, adriamycin, and L‐asparaginase. After 8 months, however, leukemia relapsed and lymphoid blasts were dominant. Cytogenetic analysis at presentation showed 46, XY, t(3;9)(p21;p22), and at relapse it showed 46, XY, t(1;3;9)(1 pter→1 q32::3p25→3pter; 3qter→3p21::9p22→9pter;9qter→9p22::3p21→3p25::1q32→1qter), t(2;19)(p21;q13). Analysis of the heavy chain joining region at diagnosis showed three hybridizing bands, all rearranged, but at relapse only one rearranged band. Analysis of the constant region for the β T‐cell receptor gene (TCRβ) both at diagnosis and at relapse showed one rearranged and one germline band, suggesting that rearrangement of one allele of TCRβ of not only lymphoid but also myeloid blasts occurred. It is considered that the target cell of lymphoid leukemia cells and that of myeloid leukemia cells at diagnosis were the same, which differentiated to two lineages, and the clone which evolved from lymphoid lineage proliferated at relapse.
Simultaneous Acute Cerebral and Pulmonary Edema Complicating Diabetic Ketoacidosis
Authors: Martin C Young
Journal: Diabetes Care (1995)

OBJECTIVE To report on a child with diabetic ketoacidosis (DKA) who developed simultaneous acute cerebral edema (CE) and pulmonary edema (PE), required extracorporeal membrane oxygenation (ECMO), and yet survived without significant neurological or pulmonary handicap. CASE SUMMARY A 3-year-old girl with DKA as the first manifestation of insulin-dependent diabetes mellitus (IDDM) sustained coincident acute CE and PE 9 h into therapy. The former responded to mannitol, but the latter matured into adult respiratory distress syndrome (ARDS) resistant to conventional management and requiring ECMO. CONCLUSIONS CE, PE, and ARDS can complicate DKA. Survival without sequelae is possible with aggressive treatment.
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation
Authors: G. Saldanha, V. Ghura, L. Potter, A. Fletcher
Journal: British Journal of Dermatology (2004)

Journal Article Nuclear β‐catenin in basal cell carcinoma correlates with increased proliferation Get access G. Saldanha, G. Saldanha University of Leicester, Department of Cancer Studies and Molecular Medicine, Level 3, Robert Kilpatrick Clinical Sciences Building, Leicester, LE2 7LX, U.K. *Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, U.K. †University Hospitals of Leicester NHS Trust, Department of Pathology, Sandringham Building, Leicester Royal Infirmary, Infirmary Close, Leicester, LE1 5WW, U.K Dr G.Saldanha. E‐mail: gss4@le.ac.uk Search for other works by this author on: Oxford Academic Google Scholar V. Ghura, V. Ghura University of Leicester, Department of Cancer Studies and Molecular Medicine, Level 3, Robert Kilpatrick Clinical Sciences Building, Leicester, LE2 7LX, U.K. *Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, U.K. †University Hospitals of Leicester NHS Trust, Department of Pathology, Sandringham Building, Leicester Royal Infirmary, Infirmary Close, Leicester, LE1 5WW, U.K Search for other works by this author on: Oxford Academic Google Scholar L. Potter, L. Potter University of Leicester, Department of Cancer Studies and Molecular Medicine, Level 3, Robert Kilpatrick Clinical Sciences Building, Leicester, LE2 7LX, U.K. *Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, U.K. †University Hospitals of Leicester NHS Trust, Department of Pathology, Sandringham Building, Leicester Royal Infirmary, Infirmary Close, Leicester, LE1 5WW, U.K Search for other works by this author on: Oxford Academic Google Scholar A. Fletcher A. Fletcher University of Leicester, Department of Cancer Studies and Molecular Medicine, Level 3, Robert Kilpatrick Clinical Sciences Building, Leicester, LE2 7LX, U.K. *Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, U.K. †University Hospitals of Leicester NHS Trust, Department of Pathology, Sandringham Building, Leicester Royal Infirmary, Infirmary Close, Leicester, LE1 5WW, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 1, 1 July 2004, Pages 157–164, https://doi.org/10.1111/j.1365-2133.2004.06048.x Published: 01 July 2004 Article history Accepted: 22 December 2003 Published: 01 July 2004
Mechanical ventilation at home.
Authors: M. A. Branthwaite
Journal: BMJ (1989)

infants suspected of having reflux are given trimethoprim from birth and then investigated by cystourethrography.We still have much to learn about prenatal ultrasonography, and the need for interdisciplinary collaboration is great.'Patients' interests are probably best served by prompt antenatal referral of suspected fetal uropathy to a regional specialist centre, even though in many instances delivery will be undertaken in the local hospital.
Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake
Authors: Giulia Coppiello, Maria Collantes, María Salomé Sirerol-Piquer, Sara Vandenwijngaert, Sandra Schoors, Melissa Swinnen, Ine Vandersmissen, Paul Herijgers, Baki Topal, Johannes van Loon, Jan Goffin, Felipe Prósper, Peter Carmeliet, Jose Manuel García-Verdugo, Stefan Janssens, Iván Peñuelas, Xabier L. Aranguren, Aernout Luttun
Journal: Circulation (2015)

Microvascular endothelium in different organs is specialized to fulfill the particular needs of parenchymal cells. However, specific information about heart capillary endothelial cells (ECs) is lacking.Using microarray profiling on freshly isolated ECs from heart, brain, and liver, we revealed a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was largely shared with skeletal muscle and adipose tissue endothelium and was enriched in genes encoding fatty acid (FA) transport-related proteins. Using gain- and loss-of-function approaches, we showed that Meox2/Tcf15 mediate FA uptake in heart ECs, in part, by driving endothelial CD36 and lipoprotein lipase expression and facilitate FA transport across heart ECs. Combined Meox2 and Tcf15 haplodeficiency impaired FA uptake in heart ECs and reduced FA transfer to cardiomyocytes. In the long term, this combined haplodeficiency resulted in impaired cardiac contractility.Our findings highlight a regulatory role for ECs in FA transfer to the heart parenchyma and unveil 2 of its intrinsic regulators. Our insights could be used to develop new strategies based on endothelial Meox2/Tcf15 targeting to modulate FA transfer to the heart and remedy cardiac dysfunction resulting from altered energy substrate usage.
New In-vitro Test for IgE-mediated Hypersensitivity in Man
Authors: M. W. Greaves, S. Yamamoto, V. M. Fairley
Journal: BMJ (1972)

A new simple and sensitive in-vitro method for the diagnosis of type 1 (IgE-mediated) hypersensitivity in man is described. Sliced human skin is passively sensitized by reaginic serum from allergic patients and the presence of antigen-specific IgE on the sensitized slices is detected by assay of antigen-evoked histamine release. Serum from 12 out of 14 patients with clinical respiratory allergy and positive skin tests gave significant antigen-specific histamine release. This method, which is essentially an in-vitro model of the Prausnitz-Küstner reaction, should prove of value in the diagnosis of human reaginic hypersensitivity in man.
Hypersensitivity to regular and intermediate, but not to crystallized, insulin as an aggravation factor for underlying bulimia nervosa in a patient with type 1 diabetes.
Authors: M Itoh, K Uchimura, M Makino, T Kobayashi, H Kakizawa, M Nagata, K Fujiwara, S Kato, Y Itoh, A Nagasaka
Journal: Diabetes Care (1999)
A case of xanthoma disseminatum: evaluation and monitoring by<sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography
Authors: S. Jin, S.Y. Chae, S.E. Chang, C. Suh, S.W. Lee, J.S. Ryu
Journal: British Journal of Dermatology (2013)

Xanthoma disseminatum (XD) is a rare benign histiocytic disorder with extensive mucocutaneous xanthomas that often involves other sites such as the central nervous system (CNS), respiratory tract and abdominal organs. Evaluation of the extent of disease is important because lesions in critical locations may increase morbidity and mortality. However, there are no well-established tools for the evaluation and monitoring of XD. Here, we report a case of XD in a 21-year-old male patient showing skin, mucous membrane, CNS and internal organ involvement. In this case, (18) F-fluorodeoxyglucose positron emission tomography/computed tomography was useful in detecting the extent of the disease and in estimating the therapeutic response.
L'INTUITION DÉLIRANTE. By <i>R. Targowla</i> and <i>J. Dublineau</i>, under the direction of <i>Drs. Henri Claude</i> and <i>J. Levy-Valensi.</i> (Paris : Editions Médicals Norbert Malvoine, 1931.)
Authors: Wilfred Scott
Journal: American Journal of Psychiatry (1934)
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition
Authors: Hiroyuki Mori, Tyler C. Prestwich, Michael A. Reid, Kenneth A. Longo, Isabelle Gerin, William P. Cawthorn, Vedrana S. Susulic, Venkatesh Krishnan, Andy Greenfield, Ormond A. MacDougald
Journal: Journal of Clinical Investigation (2012)

Preadipocytes secrete several WNT family proteins that act through autocrine/paracrine mechanisms to inhibit adipogenesis. The activity of WNT ligands is often decreased by secreted frizzled-related proteins (SFRPs). Sfrp5 is strongly induced during adipocyte differentiation and increases in adipocytes during obesity, presumably to counteract WNT signaling. We tested the hypothesis that obesity-induced Sfrp5 expression promotes the development of new adipocytes by inhibiting endogenous suppressors of adipogenesis. As predicted, mice that lack functional SFRP5 were resistant to diet-induced obesity. However, counter to our hypothesis, we found that adipose tissue of SFRP5-deficient mice had similar numbers of adipocytes, but a reduction in large adipocytes. Transplantation of adipose tissue from SFRP5-deficient mice into leptin receptor–deficient mice indicated that the effects of SFRP5 deficiency are tissue-autonomous. Mitochondrial gene expression was increased in adipose tissue and cultured adipocytes from SFRP5-deficient mice. In adipocytes, lack of SFRP5 stimulated oxidative capacity through increased mitochondrial activity, which was mediated in part by PGC1α and mitochondrial transcription factor A. WNT3a also increased oxygen consumption and the expression of mitochondrial genes. Thus, our findings support a model of adipogenesis in which SFRP5 inhibits WNT signaling to suppress oxidative metabolism and stimulate adipocyte growth during obesity.
Urinary inflammatory mediators and inhalation of hypertonic saline in children
Authors: X.‐M. Mai, M. F. Böttcher, M. Bruhammar, L. Nilsson, O. Zetterström
Journal: Allergy (2004)

Background: The inflammatory mechanisms of hypertonic saline‐induced bronchoconstriction are not well understood. Methods: Seventeen asthmatics with ( n = 11) and without bronchial hyperresponsiveness (BHR) ( n = 6) and 18 randomly selected nonatopic nonasthmatic controls without BHR were evaluated by urine samples collected before and 1 h after hypertonic saline provocation test. Histamine, 11 β ‐PGF 2 α , and LTE 4 were analysed by enzyme immunoassay (EIA) and eosinophil protein X (EPX) by radioimmunoassay (RIA). Results: The levels of leukotriene E 4 (LTE 4 ) increased significantly after the challenge tests, both in the asthmatics (median: 354 pg/mg pre‐challenge vs. 628 pg/mg post‐challenge; P = 0.05) and in the controls (median: 294 pg/mg pre‐challenge vs. 460 pg/mg post‐challenge; P &lt; 0.01). The levels of histamine also increased significantly in the latter (median: 299 μ mol/mg pre‐challenge vs. 569 μ mol/mg post‐challenge; P = 0.03). However, the levels of 11 β ‐PGF 2 α and EPX did not change significantly after the challenge tests either in the asthmatics or in the controls. Conclusions: The inhalation of hypertonic saline increased urinary excretion of LTE 4 both in the asthmatics and in the controls. The slight increase of leukotrienes was enough to induce airway obstruction in some of the asthmatics, because of the hyperresponsiveness in their airways.
Late outcome of bleeding gastric ulcers.
Authors: H L Smart, M J Langman
Journal: Gut (1986)

The subsequent progress of 152 patients treated medically in the Nottingham hospitals for bleeding gastric ulceration was analysed four to eight years later by the use of life tables. The overall cumulative rate of ulcer haemorrhage, perforation or related death was found to be 19%. Women had a greater rate than men (women 21%, men 14%) but this difference was not statistically significant. The risk of developing a recurrent complication fell with time in both groups. Women were older than men at the time of their index admission and women who suffered a late complication were significantly older than those remaining well at the end of the follow up period. No similar differences existed for men. The risk of having a late complication from a bleeding gastric ulcer compares favourably with that reported under similar circumstances for duodenal ulceration. Attempts to reduce the late complication rate should concentrate on those patients shown to be at a greater risk - that is, elderly women.
Regulation of granulomatous inflammation in murine schistosomiasis. II. T suppressor cell-derived, I-C subregion-encoded soluble suppressor factor mediates regulation of lymphokine production.
Authors: S W Chensue, D L Boros, C S David
Journal: The Journal of Experimental Medicine (1983)

In the present study, we extended the analysis of the regulation of inflammatory lymphokine production in mice with schistosomiasis mansoni. Splenic lymphocytes of chronically infected mice were briefly pulsed in vitro by soluble egg antigens, washed, and then cultured overnight. The supernatant culture fluid added to cultures of splenic cells of acutely infected or peritoneal lymphocytes of antigen-sensitized mice inhibited the production of migration inhibition factor (MIF). Elaboration of MIF suppressor factor (MIF-SF) required the Lyt-1-,2+,3+ subset of T lymphocytes. MIF-SF acted only on egg antigen-primed cells and required H-2 compatibility with the target cell for its suppressive effect. Further analysis with recombinant strains revealed that the factor interacted with I-AB or I-C subregion-compatible target cells. Experiments using immunoadsorbent columns with bound anti-I subregion alloantisera indicated that MIF-SF contained I-C subregion-encoded determinants. Extrapolation of this in vitro model to in vivo conditions would indicate that the granulomatous response is modulated by I region-derived suppressor factor(s) that regulate lymphokine production by TDH effector cells.
Immunochemical and Biological Methods for Estimation of Allergen Content Used for Soy Allergy Risk Assessments of Biotechnologically Derived Products
Authors: M.H. Pedersen, P.S. Skov, T. Holzhauser, C. Bindslev-Jensen, D.S. Brinch, L.K. Poulsen
Journal: Journal of Allergy and Clinical Immunology (2007)
Multiparametric Flow Cytometric Analysis of Inter-Patient Variation in STAT1 Phosphorylation Following Interferon Alfa Immunotherapy
Authors: G. B. Lesinski, S. V. Kondadasula, T. Crespin, L. Shen, K. Kendra, M. Walker, W. E. Carson
Journal: JNCI Journal of the National Cancer Institute (2004)

Background: Regulation of gene expression by signal transducer and activator of transcription 1 (STAT1) within host tissues mediates the antitumor effects of interferon alfa (IFN α). We used a novel flow cytometric assay to examine phosphorylation-mediated activation of STAT1 within immune effector cell subsets following in vitro or in vivo IFN α treatments. Methods: Peripheral blood mononuclear cells (PBMCs) isolated from healthy donors (n = 17) or melanoma patients (n = 19) were treated in vitro with interferon alfa-2b (IFN α-2b) or phosphate-buffered saline (PBS) and subjected to multiparametric flow cytometry to measure the levels of phosphorylated STAT1 (P-STAT1) within immune cell subsets. We similarly analyzed PBMCs isolated from melanoma patients before and 1 hour after immunotherapy with IFN α-2b. All statistical tests were two-sided. Results: P-STAT1 levels in all major immune cell subsets increased within 15 minutes of in vitro IFN α-2b treatment of PBMCs; the increase was most pronounced in T lymphocytes and monocytes. Relatively low doses of IFN α-2b (i.e., 10 2 –10 3 IU/mL) induced maximal STAT1 activation in vitro . Compared with melanoma patients, healthy donors had higher basal levels of P-STAT1 (specific fluorescence [Fsp]; i.e., Fsp PBS , the level of P-STAT1 in PBS-treated cells) in total PBMCs, natural killer (NK) cells, and T cells (mean Fsp PBS in total PBMCs: 5.5 in healthy donors versus 1.6 in patients, difference = 3.9, 95% confidence interval [CI] = 1.4 to 6.5, P = .004; mean Fsp PBS in NK cells: 4.6 in healthy donors versus 0.9 in patients, difference = 3.7, 95% CI = 1.7 to 5.7, P = .001; mean Fsp PBS in T cells: 6.8 in healthy donors versus 0.9 in patients, difference = 5.9, 95% CI = 2.5 to 9.3, P = .002). P-STAT1 was detected in the NK and T cells of two patients who received IFN α-2b immunotherapy (20 MU/m 2 [MU = million units], administered by intravenous injection). P-STAT1 levels in the PBMCs of a patient treated sequentially with 5 MU/m 2 and 10 MU/m 2 IFN α-2b (administered by subcutaneous injection) also increased in response to treatments with IFN α-2b but did not increase further with the increased dosage of IFN α-2b. Conclusion: This flow cytometry method can be used to monitor STAT1 activation within subsets of immune cells from patients undergoing IFN α immunotherapy.
Genetic Testing in Hereditary Colorectal Cancer
Authors: Francis M. Giardiello
Journal: JAMA (1997)

<h3>CASE PRESENTATION</h3> A 29-year-old woman presented to her family physician with a 2-month history of 30 to 44 mL (2-3 tbsp) of bright red blood per rectum with every bowel movement. She was referred to a surgeon, who performed anoscopy and gave her a diagnosis of hemorrhoidal bleeding. She underwent hemorrhoidal surgery of unknown type. The patient again sought medical attention 3 months later, complaining of persistent and unchanged rectal bleeding. She had no change in bowel habits, weight loss, or family history of colorectal cancer or polyps. Examination of her skin did not show osteomas, lipomas, or epidermoid cysts. Direct ophthalmoscopic examination revealed no pigmentation of the retinal epithelium. Abdominal examination was normal. A stool sample taken during rectal examination tested guaiac positive. The results of an upper gastrointestinal tract barium series were normal, but air contrast barium enema showed multiple filling defects throughout the colorectum. Subsequent colonoscopy revealed
909-24 Intravascular Ultrasound Validation of a Semiquantitative Angiographic Classification of Coronary Artery Target Lesion Calcium
Authors: Gary S. Mintz, Jeffrey J. Popma, Augusto D. Pichard, Kenneth M. Kent, Lowell F. Satler, Ya Chien Chuang, Jennifer Griffin, Martin B. Leon
Journal: Journal of the American College of Cardiology (1995)
507 CCR1, SYNDECANS 1 AND 4, ARE INVOLVED IN RANTES/CCL5-MEDIATED MIGRATION OR INVASION OF HUMAN HEPATOMA CELLS
Authors: F. Charni, V. Friand, N. Suffee, O. Haddad, O. Oudar, L. Martin, R. Vassy, L. Gattegno, A. Sutton, N. Charnaux
Journal: Journal of Hepatology (2009)
Formation of strong airway irritants in mixtures of isoprene/ozone and isoprene/ozone/nitrogen dioxide.
Authors: C K Wilkins, P A Clausen, P Wolkoff, S T Larsen, M Hammer, K Larsen, V Hansen, G D Nielsen
Journal: Environmental Health Perspectives (2001)

We evaluated the airway irritation of isoprene, isoprene/ozone, and isoprene/ozone/nitrogen dioxide mixtures using a mouse bioassay, from which we calculated sensory irritation, bronchial constriction, and pulmonary irritation. We observed significant sensory irritation (approximately 50% reduction of mean respiratory rate) by dynamically exposing the mice, over 30 min, to mixtures of isoprene and O3 or isoprene, O3, and NO2. The starting concentrations were approximately 4 ppm O3 and 500 ppm isoprene (+ approximately 4 ppm NO2. The reaction mixtures after approximately 30 sec contained < 0.2 ppm O3. Addition of the effects of the residual reactants and the identified stable irritant products (formaldehyde, formic acid, acetic acid, methacrolein, and methylvinyl ketone) could explain only partially the observed sensory irritation. This suggests that one or more strong airway irritants were formed. It is thus possible that oxidation reactions of common unsaturated compounds may be relevant for indoor air quality.
Phylogenetic history of LINE-1 among arvicolid rodents
Authors: W. S. Modi
Journal: Molecular Biology and Evolution (1996)

The extent of restriction fragment sharing among arvicolid rodents was examined following Southern blotting with a reverse transcriptase region probe from long interspersed nuclear element 1 (LINE-1 or L1). DNAs from 30 species belonging to nine genera were digested with 11 restriction endonucleases. Following hybridization discrete bands were scored with respect to their presence or absence and intensity, and both within- and between-species comparisons were conducted. Intraspecific analyses revealed low but detectable levels of variation. Interspecific comparisons revealed three groups of bands: those present in all 30 species (6 out of a total of 248 bands), those phylogenetically informative in two or more species (130 out of 248), and those unique to a single species (114 out of 248). A multistate data matrix consisting of species by codes representing the intensities of informative bands was analyzed by maximum parsimony. Further, distance values between species were converted to rates using estimated fossil divergence times. Both the parsimony and rate analyses revealed differences between species in the extent of band sharing and in the intensities of common bands, indicating that the amplification and movement of LINE elements has occurred in episodic bursts during the history of this group. Systematic interpretations of the evolutionary trees were concordant with those previously obtained using other data sets, suggesting that although the amplification of repetitive sequences may occur episodically in this taxonomic group, there do appear to be some constraints.
OPTIMIZED TOUCH TECHNIQUES IN ATRIAL FIBRILLATION ABLATION: LONG-TERM FOLLOW-UP COMPARING THE CONTACT FORCE GUIDED APPROACH TO MAGNETICALLY DIRECTED ABLATION TECHNOLOGY
Authors: Klaus J. Gutleben, Bogdan Muntean, Dieter Horstkotte, Juergen Vogt, Georg Noelker
Journal: Journal of the American College of Cardiology (2013)
1106-184 An antiulcer drug, geranylgeranylacetone, suppresses nitric oxide synthesis in cytokine-stimulated cultured vascular smooth muscle cells
Authors: Keiji Yamamoto, Mutsuko Sarukawa, Takayuki Ito, Masahisa Shimpo, Masaru Ichida, Kazuyuki Shimada
Journal: Journal of the American College of Cardiology (2004)
CLINICAL AND PROGNOSTIC VALUE OF GALECTIN-3, A NOVEL FIBROSIS-ASSOCIATED BIOMARKER. RELATION WITH CLINICAL AND BIOCHEMICAL CORRELATES OF HEART FAILURE.
Authors: Rudolf A. De Boer, Dirk Lok, Johannes L. Hillege, Adriaan A. Voors, Wiek H. van Gilst, Tiny Jaarsma, Dirk J. van Veldhuisen
Journal: Journal of the American College of Cardiology (2010)