Fluconazole Treatment of Persistent <i>Cryptococcus neoformans</i> Prostatic Infection in AIDS
Authors: Samuel A. Bozzette, Robert A. Larsen, Joseph Chiu, Mary Ann E. Leal, Jeremiah G. Tilles, Douglas D. Richman, John M. Leedom, J. Allen McCutchan
Journal: Annals of Internal Medicine (1991)

Brief Reports15 August 1991Fluconazole Treatment of Persistent Cryptococcus neoformans Prostatic Infection in AIDSSamuel A. Bozzette, MD, Robert A. Larsen, MD, Joseph Chiu, MD, Mary Ann E. Leal, MD, Jeremiah G. Tilles, MD, Douglas D. Richman, MD, John M. Leedom, MD, J. Allen McCutchan, MDSamuel A. Bozzette, MDSearch for more papers by this author, Robert A. Larsen, MDSearch for more papers by this author, Joseph Chiu, MDSearch for more papers by this author, Mary Ann E. Leal, MDSearch for more papers by this author, Jeremiah G. Tilles, MDSearch for more papers by this author, Douglas D. Richman, MDSearch for more papers by this author, John M. Leedom, MDSearch for more papers by this author, J. Allen McCutchan, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-4-285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe prostate gland is a common site for persistent and recurrent Cryptococcus neoformans infection after amphotericin B therapy for cryptococcal meningitis in patients with the acquired immunodeficiency syndrome (AIDS) (1, 2). Additional prolonged amphotericin B therapy up to total doses of six grams has not led to suppression of cryptococcuria, and discontinuation of therapy has led to recurrence of disseminated infection (1 and unpublished data). In seeking more effective therapies, we prospectively studied patients treated with fluconazole, an orally absorbed triazole that has excellent tissue penetration and antifungal activity in cryptococcal infection (2-5).Patients and MethodsWe studied 14 patients...References1. LarsenBozzetteMcCutchanChiuLealRichman RSJJMD. Persistent Cryptococcus neoformans infection of the prostate after successful treatment of meningitis. California Collaborative Treatment Group. Ann Intern Med. 1989;111:125-8. LinkGoogle Scholar2. BozzetteLarsenChiuLealJacobsenRothman SRJMJP. A placebo-controlled trial of maintenance therapy with fluconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome. California Collaborative Treatment Group. N Engl J Med. 1991;324:580-4. CrossrefMedlineGoogle Scholar3. SaagDismukes MW. Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother. 1988;32:1-8. CrossrefMedlineGoogle Scholar4. SternHartmanSharkeyRowlandSquiresMurray JBPVKH. Oral fluconazole therapy for patients with acquired immunodeficiency syndrome and cryptococcosis: experience with 22 patients. Am J Med. 1988;85:477-80. CrossrefMedlineGoogle Scholar5. LarsenLealChan RML. Fluconazole compared with amphotericin B plus flucytosine for cryptococcal meningitis in AIDS. A randomized trial. Ann Intern Med. 1990;1:183-7. LinkGoogle Scholar6. ChuckSande SM. Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N Engl J Med. 1989;321:794-9. CrossrefMedlineGoogle Scholar7. ZugerLouieHolzmanSimberkoffRahal AERMJ. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986;104:234-40. LinkGoogle Scholar8. KovacsKovacsPolisWrightGillTuazon JAMWVC. Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:533-8. LinkGoogle Scholar9. DiamondBennett RJ. Prognostic factors in cryptococcal meningitis. A study in 111 cases. Ann Intern Med. 1974;80:176-81. LinkGoogle Scholar10. ZugerSchusterSimberkoffRahalHolzman AMMJR. Maintenance amphotericin B for cryptococcal meningitis in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1988;109:592-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of California San Diego, the University of Southern California Los Angeles, and the University of California Irvine, California. For a listing of additional members of the California Collaborative Treatment Group and current author addresses, see end of text.The following additional members of the California Collaborative Treatment Group participated in this study: University of California San Diego: Kris Large, RN; Mary McCarthy, RN; Chris Fegan, RN; T. C. Meng, MD; University of California Irvine: Sheila Fitzgibbons, RN. 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II. cryptococcosisFluconazole (Diflucan®): a reviewFuture Therapies in the Management of Critically Ill, AIDS PatientsAids: Part IISuppressive Therapy for Cryptococcal MeningitisCryptococcal Infection in AIDS 15 August 1991Volume 115, Issue 4Page: 285-286KeywordsAIDSAmphotericinAntifungalsCryptococcal meningitisCryptococcosisCryptococcus neoformansInfectious diseasesProstate gland Issue Published: 15 August 1991 PDF DownloadLoading ...