tbuckley/cabot-search huggingface dataset:
A Randomized Controlled Trial of the Effect of Aerobic Exercise Training on Feelings of Energy and Fatigue in Sedentary Young Adults with Persistent Fatigue
Authors: Timothy W. Puetz, Sara S. Flowers, Patrick J. O’Connor
Journal: Psychotherapy and Psychosomatics (2008)

&lt;i&gt;Background:&lt;/i&gt; There is growing evidence that chronic exercise is a promising intervention for combating feelings of low energy and fatigue. Although groups with well-defined medical conditions (for example cancer and heart disease) or unexplained fatigue syndromes consistently have reported improved feelings of energy and fatigue after chronic exercise, relatively few exercise training studies have been conducted with people who report persistent fatigue yet neither have a medical condition nor reach diagnostic criteria for an unexplained fatigue syndrome. The purpose of this investigation was to use a randomized controlled design to examine the effects of 6 weeks of chronic exercise training on feelings of energy and fatigue in sedentary, healthy young adults reporting persistent fatigue. &lt;i&gt;Methods:&lt;/i&gt; Thirty-six healthy, young adults who reported persistent feelings of fatigue were randomly assigned to a moderate-intensity exercise, low-intensity exercise or no treatment control group. Participants in each condition then visited the exercise laboratory on 18 occasions over a 6-week period. Exercise laboratory visits occurred 3 days per week. Vigor and fatigue mood state scores were obtained at the beginning of the third exercise session each week for 6 weeks. Aerobic fitness was measured before and after intervention. &lt;i&gt;Results:&lt;/i&gt; The effect of 6 weeks of exercise training on feelings of fatigue was dependent on exercise intensity; however, the effect on feelings of energy was similar for both the low- and moderate-intensity conditions. The changes in feelings of energy and fatigue were independent of changes in aerobic fitness. &lt;i&gt;Conclusions:&lt;/i&gt; Six weeks of low and moderate exercise training performed by sedentary adults without a well-defined medical condition or an unexplained fatigue syndrome but reporting persistent feelings of fatigue resulted in similarly beneficial effects on feelings of energy. The effects for symptoms of fatigue were moderated by exercise intensity, and the more favorable outcome was realized with low-intensity exercise. Changes in feelings of energy and fatigue following exercise training were unrelated to changes in aerobic fitness.
Changes in the Characteristics of Metabolic Syndrome in Korea Over the Period 1998–2001 as Determined by Korean National Health and Nutrition Examination Surveys
Authors: Soo Lim, Kyong Soo Park, Hong Kyu Lee, Sung-Il Cho
Journal: Diabetes Care (2005)

Metabolic syndrome has been shown to be associated with cardiovascular morbidity and mortality (1,2). In the U.S., 23.7% of the population was classified as having metabolic syndrome by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III definition when the Third National Health and Nutrition Examination Survey (NHANES III) data were used (3). According to the recent study by Ford et al. (4), the age-adjusted prevalence of metabolic syndrome was 27.0% based on data from the U.S. NHANES 1999–2000 study. Thus, the number of individuals with metabolic syndrome is increasing, and an increasing trend has been observed in Asian countries (5,6).

During the period 1970–1980, Korea experienced an epidemiologic switchover from infectious diseases to chronic degenerative diseases (7). A westernization of diet and a reduction in physical activity seem to have evoked metabolic imbalance, obesity, and an explosive increase in cardiovascular disease and diabetes. In particular, Korea experienced an economic crisis during the period 1997–1998 due to a collapse in the value of the currency, which was followed by an increase in the death rate (8).

Thus, we considered that changes in the prevalence of metabolic syndrome around this time would be of interest. In 1998, when the Korean economy was …
CASE OF NECROSIS OF BONES OF THE SKULL.
Authors: W. U. COLE
Journal: JAMA (1902)

The patient is a housewife, aged 34, is a native of Ohio, and is married, hut has no children. Seven years ago she came to my office for the first time, suffering from headache and pain in the left hip. She presented a sallow, anemic appearance, and was somewhat emaciated. I also noticed that the anterior and upper frontal regions were unduly prominent, but the skin showed no discoloration. Six months later she called again. Apparently an abscess had formed at the apex of the prominence to the left of the median line, where she complained of severe throbbing pain. The skin over the site of the abscess was a dark-red color, and at one point some signs of ulceration were already visible. I evacuated the abscess under anesthesia. A cheesy tuberculous deposit filled the cavity. At its base I noticed a roughened condition of the bone, and found that
"The end of an age of optimism".
Authors: J S Bradshaw
Journal: BMJ (1979)

in the short term can reduce the protein loss from the stomach.3-Varioustreatments that can lower hydrogen ion secretion by the gastric mucosa-long-term propantheline,7 vagotomy,'; and cimetidine5-have also decreased protein loss, relieved symptoms, and, in the case of cimetidine and vagotomy, lead to mucosal improvement, though hypo- secretion of acid is a prerequisite for making the diagnosis.The fibrinolysis inhibitor tranexamic acid has been reported to relieve symptoms, reduce protein loss, and lead to mucosal recovery, 9 although here also spontaneous recovery cannot be excluded.What is clear from reports is that treatment should be expectant, with therapeutic trials of the various agents that have been shown to be of value in some cases.Surgery should be reserved for certain definite indications- namely, prolonged intractable symptoms with severe hypoproteinaemic oedema, gastric bleeding, and neoplastic change.10A patient under our care at Hammersmith Hospital indicated the value of expectant treatment.A 29-year-old woman presented with nausea, vomiting, cpigastric pain, weight loss, and hypoproteinaemic oedema.She failed to show any definite improvement with anticholinergics and tranexamic acid.With encouragement and symptomatic treatment she improved over three months so that she was without symptoms and could return to work although her gastric mucosa was unchanged.We cannot be sure that surgery may not be necessary at some time, but at least she was spared a total gastrectomy at her initial presentation, when many would have been tempted to perform it.
THE DISTRIBUTION AND STORAGE OF BLUE ANTIGENIC AZOPROTEINS IN THE TISSUES OF MICE
Authors: Heinz Kruse, Philip D. McMaster
Journal: The Journal of Experimental Medicine (1949)

Intensely blue dye-azoproteins have been prepared by diazotization and coupling of the highly indiffusible blue dye T-1824, Evans blue, with various serum proteins and egg albumin. The products, whether purified by precipitation with alcohol or by chromatography, have a constant dye-to-protein ratio and tests have shown them to be essentially free from unlinked dye. An extremely diffusible dye, echt-säure-blau, has also been coupled to bovine γ-globulin. These materials are adapted to physiological experimentation. They seem to behave in the bodies of mice like other proteins; they fail to appear in either the bile or urine of normal animals, and they are strongly antigenic. When these soluble antigenic azoproteins are injected into the blood stream of mice for the first time they enter reticulo-endothelial cells in almost every organ of the body; the final distribution is like that of intravenously injected, finely divided particulate matter. The azoproteins appear in the cells which classical immunological studies have shown to be active in removing particulate antigenic materials or bacteria from the blood or body fluids. The Kupffer cells of the liver and sinus and reticular cells in lymph nodes, especially the great mesenteric node, are particularly active in the removal of the blue antigens from the blood, but many other R-E cells are active to a lesser degree. The storage of the antigenic material is in the cytoplasm only; it has not been seen within nuclei, nor has it been seen within cells of the brain. Serological methods disclose that the blue material seen within Kupffer cells of the liver after as long a period as 2 days is still antigenic in its reactions. The blue azoproteins, therefore, serve excellently as tracer antigens, especially since they can be seen directly in fresh and fixed tissue preparations and in the body fluids.
MEDICAL REVERIES
Authors: Ervin Epstein
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pregnancy and immunity
Authors: G M Stirrat
Journal: BMJ (1994)

<h3>AIM</h3> To describe the authors9 experience with discontinuation of anti-cytomegalovirus (CMV) maintenance therapy in patients showing immune recovery following highly active antiretroviral therapy (HAART). <h3>METHODS</h3> Retrospective analysis of the records of 41 patients who presented with CMV retinitis and whose maintenance therapy was discontinued from March 1997 to December 1999. <h3>RESULTS</h3> 41 patients had their anti-CMV therapy discontinued. The mean follow up after discontinuation of maintenance therapy in April 2000 was 20.4 months. At the time of discontinuation of maintenance therapy the lowest CD4+ count was 143 cells ×10<sup>6</sup>/l and only three patients had detectable HIV viral load. No reactivation or progression was seen in any of these patients after suspension of maintenance therapy. <h3>CONCLUSION</h3> The anti-CMV maintenance therapy could be discontinued safely in patients with CD4+ above 150 cells ×10<sup>6</sup>/l although close follow up remains necessary especially in patients whose CD4+ count drops below this level.
Comparative response to splenectomy in coombs-positive autoimmune hemolytic anemia with or without associated disease
Authors: Gorgun Akpek, David McAneny, Lewis Weintraub
Journal: American Journal of Hematology (1999)

We reviewed our experience in 30 patients with direct Coombs-positive (DAT+) autoimmune hemolytic anemia (AHA) who underwent splenectomy. Twelve patients had idiopathic "warm" AHA (group I) and 18 had AHA associated with systemic diseases (group II). Complete response to splenectomy was defined as having normal hemoglobin and reticulocyte count lasting for at least 6 months without subsequent medical therapy. Subnormal but greater than 50% improvement in these parameters with or without medical therapy was considered to be a partial response. Median age was 64 (23–81) in group I and 68 (23–76) in group II. Median follow-up duration was 18 and 10.9 months, respectively. Nine of 11 (82%) evaluable patients with idiopathic AHA and 3 of 16 (19%) patients with associated disease achieved a complete response. Partial response was obtained in 2 (18%) and 6 (37%) patients in groups I and II, respectively. Both complete-response and overall-response rates were statistically different between two groups (P = 0.001 and 0.02). Postoperative courses of group I patients were uneventful except for one who developed a subphrenic abscess. Five patients in group II developed bacterial infections, which were mostly pneumonias. Our findings indicate that splenectomy is an effective treatment approach with low morbidity and mortality in patients with refractory idiopathic AHA. It should, however, be considered cautiously in AHA patients with underlying systemic diseases because of its decreased efficacy and increased surgical morbidity in this subgroup. Am. J. Hematol. 61:98–102, 1999. © 1999 Wiley-Liss, Inc.
Sustained moderate reductions in arterial CO2 after brain trauma Time-course of cerebral blood flow velocity and intracranial pressure
Authors: Luzius A. Steiner, Marcella Balestreri, Andrew J. Johnston, Marek Czosnyka, Jonathan P. Coles, Doris A. Chatfield, Peter Smielewski, John D. Pickard, David K. Menon
Journal: Intensive Care Medicine (2004)
Adult Supraglottitis
Authors: Jo Shapiro
Journal: JAMA (1988)

Epiglottitis in pediatric patients is an infection caused by<i>Haemophilus influenzae</i>type b, which can lead rapidly to sepsis and an asphyxial death. In an effort to study the cause and clinical course of adult epiglottitis, eight serially hospitalized adult patients with supraglottitis over a ten-month period were prospectively evaluated, including a daily laryngeal examination. Although multiple anatomic sites in the larynx and oropharynx were inflamed, the epiglottis was often not the most involved area and was actually normal in one patient. Bacterial cultures were harvested from blood, the nasopharynx, the oropharynx, and the vallecula in all patients and the preepiglottic space in two patients. In no case was<i>H influenzae</i>demonstrated. No patient developed respiratory compromise. It was concluded that epiglottitis is an inaccurate description of this disorder and that this non—<i>H influenzae</i>adult variety of supraglottitis seemingly can follow a less pernicious course than the classically described infection. (<i>JAMA</i>1988;259:563-567)
JAK2-V617F activating mutation in acute myeloid leukemia: prognostic impact and association with other molecular markers
Authors: C Vicente, I Vázquez, N Marcotegui, A Conchillo, C Carranza, G Rivell, E Bandrés, I Cristobal, I Lahortiga, M J Calasanz, M D Odero
Journal: Leukemia (2007)
Thermal Changes in the Normal Menstrual Cycle
Authors: J. Marshall
Journal: BMJ (1963)

AMyCA JOYRN erect position does not possess any of its theoretical advantages and (2) it is impracticable as long as a bed- rest is being used to maintain the position.It is, however, suggested that a further study of a larger series of cases with the use of cardiac or surgical beds may yield more precise information.
The Doctor's Changing Role
Authors: John Lister
Journal: New England Journal of Medicine (1971)

The British Medical Association held its annual conference in Leicester this year, and the many topics discussed at the business meetings reflected the continuing difficulty that the profession is having in defining its role not only within the National Health Service but in relation to the rapidly changing conditions of modern society. It was also made apparent that there are still many problems arising from the conflicting interests of different sections of the profession. General practitioners at present seem relatively content, because there is no doubt that conditions in general practice have greatly improved and that the general practitioner remains . . .
How the Defunct Osteopathy Bill was Passed by the Illinois Legislature.
Authors: T. W. Davidson
Journal: JAMA (1897)

Oneida, Ill., Aug. 20, 1897. <h3>To the Editor:</h3> —I send you a<i>Journal of Osteopathy</i>. I know something of how they managed the late House at Springfield, which may be of interest, as I am well acquainted with our representative, Murdock. While the bill was being agitated I went to him and asked for his influence against it. He informed me that he was in favor of it, that one of the operators in the cult was at the capital demonstrating the treatment and one of the members who had sometime previously been laid up with an attack of rheumatism for six weeks, was taken suddenly one evening with a similar attack, and the osteopathic gentleman asked to be allowed to treat him just once and was granted the request. He at once proceeded to carry out the treatment in view of several of the other members. To use Mr.
Synergistic augmentation of CD40-mediated activation of antigen-presenting cells by amphiphilic poly(γ-glutamic acid) nanoparticles
Authors: Sissela Broos, Linda C. Sandin, Jenny Apel, Thomas H. Tötterman, Takami Akagi, Mitsuru Akashi, Carl A.K. Borrebaeck, Peter Ellmark, Malin Lindstedt
Journal: Biomaterials (2012)
TRANSVERSE BAND PIGMENTATION OF FINGERNAILS AFTER X-RAY THERAPY
Authors: Richard L. Sutton
Journal: JAMA (1952)

A transverse band in a nail is caused by a temporary alteration in the normal production of nail substance as it is produced by the nail matrix that underlies the proximal nail fold.<sup>1</sup>A fingernail band that is concave distally is usually caused by the trauma of manicuring, the nail being temporarily damaged by the instrument as it pushes back and follows the curve of the proximal nail fold. A distally convex band is generally caused by a temporary abnormality of the skin of the dorsum of the terminal phalanx. Contact or parasitic dermatitis of a digit will produce this in one nail; systemic disease, such as lobar pneumonia, is capable of producing transverse bands in the nails of both the hands and the feet. When a patient has distally convex, transverse bands only of all nails of the hands, the conditions leading to the abnormality are uncommon. Pigmentation
The move to preserve therapeutic cloning
Authors: Karen Birmingham
Journal: Journal of Clinical Investigation (2003)

In mid-October 2003, on the eve of the annual meeting of the American Society for Reproductive Medicine (ASRM) in Texas, the Cypriot-born physician Panayiotis Zavos held a press conference to announce that he had frozen a cloned human embryo at the 10-cell stage and was preparing to implant it in a woman. As with his previous claims, Zavos offered no scientific data to support his work. Nonetheless, there is fresh concern within the research community that such outlandish remarks are fueling political efforts to ban all forms of cloning, both reproductive and therapeutic Scientists are now rallying to stop mavericks like Zavos.

Kellie Tamashiro, part of the University of Cincinnati team that showed adult cloned mice become obese as a side effect of the cloning procedure (1), articulates the issue: “We need to be aware that people such as Zavos may be attempting to clone humans and need to ensure that cloning done by other researchers using various animal models is not prematurely halted as a result of his claims and activities.”

Lawrence Goldstein, a Howard Hughes Investigator from UCSD, agrees. “It’s not that there’s an increased activity of those trying to clone humans — or that they’re any closer — it’s just that there’s an increased number of claims. People legitimately feel this is an inappropriate activity and there ought to be a ban on human cloning that will also stop the claims.”

Joe Massey, of the Atlanta-based Southeastern Fertility Institute, believes that a year ago, researchers wouldn’t have bothered to enlist support for a human cloning ban. Yet during that time, embryonic stem cell research and nuclear transfer in animals has progressed apace. “This possible pathway of scientific inquiry is being guarded by scientists who would like to pursue it,” he told the JCI.
Erythrocyte metabolism in purine nucleoside phosphorylase deficiency after enzyme replacement therapy by infusion of erythrocytes.
Authors: G E Staal, J W Stoop, B J Zegers, L H Siegenbeek van Heukelom, M J van der Vlist, S K Wadman, D W Martin
Journal: Journal of Clinical Investigation (1980)

Purine nucleoside phosphorylase deficiency is associated with a severely defective T-cell immunity. A patient with purine nucleoside phosphorylase deficiency was treated with transfusions of irradiated erythrocytes and plasma. This resulted in a remarkable correction of the metabolic disturbances in the patient. The urinary excretion of inosine, deoxyinosine, guanosine, and deoxyguanosine decreased, whereas uric acid excretion as well as serum uric acid concentration increased. It could be shown that the enzyme activity of the circulating erythrocytes correlated inversely with the urinary excretion of nucleosides and directly with the excretion of uric acid. As a consequence of the therapy, several glycolytic intermediates of the erythrocytes were increased, especially 2,3-diphosphoglycerate. The high 2,3-diphosphoglycerate level caused a shift to the right of the oxygen dissociation curve (P50 = 32.9 mm Hg). The immunological status of the patient showed definite improvement after the enzyme replacement therapy.
Copulsation Balloon for Right Ventricular Assistance
Authors: Dennis R. Trumble, Chong S. Park, James A. Magovern
Journal: Circulation (1999)

Background —Options for management of acute right ventricular (RV) failure are limited. This report describes preliminary testing of a temporary RV assist device that acts by direct compression of the RV. The system comprises a pancake-shaped silicone balloon (5 cm diameter) connected to a drive console that delivers a 65-mL pneumatic pulse during cardiac systole. Methods and Results —Initial in vivo tests were performed on 6 pigs (weight, 41±4 kg). RV wall motion and stroke volume were monitored via transesophageal echocardiography. Acute RV failure was created by graded right coronary ligation, which yielded a 63% reduction in RV stroke volume (39.9±8.2 to 14.7±1.9 mL; P &lt;0.002). We secured the balloon over the RV free wall by attaching it to the edges of the opened pericardium. The sternum was then reapproximated, and data were collected with the device off and on (every beat). Device placement had no deleterious effect on RV function. Balloon activation returned RV stroke volumes to normal (37.8±9.2 mL) and increased mean pulmonary artery pressures from 13±2 to 16±3 mm Hg ( P &lt;0.01). RV compression did not induce or exacerbate tricuspid regurgitation. Mean aortic pressure improved from postinfarction levels but did not return to normal. Conclusions —We conclude that the pulmonary circulation can be supported in the short term via cardiac compression and that balloon copulsation techniques for short-term RV failure should be tested in long-term models.