tbuckley/cabot-search huggingface dataset:
Hyperadrenergic State After Trauma to the Neuroaxis
Authors: Jacobo Wortsman
Journal: JAMA (1980)

INCREASED catecholamine excretion rates have been reported in pheochromocytoma, congestive heart failure, myocardial infarction, cerebrovascular accident,<sup>1</sup>and CNS trauma.<sup>2</sup>This article describes a patient who had persistent hypertension associated with elevated catecholamine excretion rates subsequent to trauma to the CNS. This pheochromocytomalike syndrome may be a common complication of trauma to the CNS. <h3>Report of a Case</h3> A 40-year-old man was hospitalized after being involved in a high-speed boating accident. At the time of the accident, the patient lost consciousness for one to two minutes; however, there were no external signs of injury to the head. On initial examination, the patient was in no acute distress. Blood pressure was 140/90 mm Hg while he was supine, and the pulse rate was 90 beats per minute and regular. There was complete paralysis of the right arm, with swelling of the right cervical region extending down to the arm. Roentgenograms
Patient Preferences for Deactivation of Implantable Cardioverter-Defibrillators
Authors: John A. Dodson, Terri R. Fried, Peter H. Van Ness, Nathan E. Goldstein, Rachel Lampert
Journal: JAMA Internal Medicine (2013)

While implantable cardioverter defibrillators (ICDs) prolong life, painful shocks can occur at the end of life, and physicians rarely discuss the option of device deactivation 1,2. To prevent shocks at the end of life that do not meaningfully prolong survival, a recent Heart Rhythm Society consensus statement recommended proactive communication with patients regarding deactivation 3. However, most surveys have found that the majority of ICD patients would not consider deactivation in even in deleterious future health states including terminal cancer 4, constant dyspnea 5, or receipt of frequent shocks 5,6.

We examined preferences for ICD deactivation in the context of health outcomes such as functional and cognitive disability shown to matter most to patients 7. Our survey provided an informational description of the potential benefits and burdens of the shocking function of ICDs, and subsequently presented scenarios describing broad health outcomes common in patients approaching the end of life.
Declining Severity of Rheumatic Fever
Authors: Edward F. Bland
Journal: New England Journal of Medicine (1960)

THE present report concerns the nature and extent of the decline in severity of rheumatic fever in recent years and certain factors that may have been in part responsible. It is based upon the long-term studies of rheumatic fever at the House of the Good Samaritan in Boston dating back to 1921.1 These studies, organized by the late Dr. T. Duckett Jones, have been carried on by him and his associates in the intervening years. They not only include an early era when this disease outnumbered all others as a cause of death in childhood but also extend over the . . .
Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance
Authors: Ilaria Iacobucci, Annalisa Lonetti, Francesca Messa, Daniela Cilloni, Francesca Arruga, Emanuela Ottaviani, Stefania Paolini, Cristina Papayannidis, Pier Paolo Piccaluga, Panagiota Giannoulia, Simona Soverini, Marilina Amabile, Angela Poerio, Giuseppe Saglio, Fabrizio Pane, Giorgio Berton, Anna Baruzzi, Antonella Vitale, Sabina Chiaretti, Giovanni Perini, Robin Foà, Michele Baccarani, Giovanni Martinelli
Journal: Blood (2008)
Abstract 785: The progesterone induced blocking factor, an immunomodulatory protein that may suppress natural killer cell activity in the tumor microenvironment, found to be a soluble protein possibly allowing the development of an enzyme-linked immunoabsorbent assay
Authors: Rachael Cohen, Maya Srivastava, Jerome H. Check, Ebony Dix
Journal: Cancer Research (2011)

Abstract A unique 34 kDa protein expressed by gamma delta thymic (T) cells during pregnancy suppresses natural killer (NK) cell activity and helps to shift the balance of thymic helper (TH) 1 to TH2 cytokine dominance. The mechanism involved in making this immunomodulaotry protein involves de novo induction of progesterone (P) receptors on gamma delta T cells by the allogeneic stimulus of the fetal semi-allograft and the interaction of the P receptors with a high concentration of P generated at the maternal fetal interface. There is evidence that certain cancer cells may use a similar mechanism to escape NK cell surveillance as evidenced by all 27 different human leukemia cells tested showing a very high level of messenger RNA for this immunomodulatory protein known as the progesterone induced blocking factor (PIBF). Furthermore adding the P receptor antagonist mifepristone down-regulated PIBF expression. PIBF may be synthesized by gamma delta T cells in the tumor microenvironment of solid tumors thus inhibiting NK cell immunosurveillance. Previous studies were performed using an immunocytochemistry technique using a polyclonal antibody because the PIBF protein was not purified. Recombinant DNA technology has allowed the production of a pure protein and thus the development of a monoclonal antibody. The present study was aimed at determining if PIBF is a soluble protein, which if it is could lead to the development of a much more practical and sensitive enzyme linked immunoabsorbent assay (ELISA). Serum samples were blindly assessed for the presence of PIBF using a novel sandwich ELISA we developed with full length (amino acid 1 to 757) recombinant human PIBF, rabbit polyclonal antibody to amino acid 1-300, and affinity purified goat polyclonal antibody to the internal region of PIBF conjugated to horseradish peroxidase. Color was developed using tetramethylbenzidine substrate stopped by 2N H2SO4 and read at 450 lambda. Bovine serum albumin served as negative control. Soluble PIBF was detected in several samples, with highest levels in pregnant patients at over 10 microgram/ml concentration. There were significant inter-individual differences. PIBF, does indeed also exist in a soluble form and can be detected in serum. With further refinement of our ELISA we aim to improve sensitivity and specificity, allowing for the simple measurement of PIBF on a rapid, high throughput basis, making it a more practical test to predict cancers that would benefit from progesterone receptor antagonist therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 785. doi:10.1158/1538-7445.AM2011-785
Attendances at Charing Cross and Hammersmith Hospitals' urgent care centres, 2009-12
Authors: T. E. Cowling, F. Ramzan, A. Majeed, S. Gnani
Journal: BMJ (2013)

Charing Cross and Hammersmith Hospitals’ accident and emergency services will be reconfigured under current plans.1 Both hospitals currently possess a GP led urgent care centre co-located with an emergency department; self referred patients are unable to access emergency departments without being seen by a GP or emergency nurse practitioner in an …
Simple Principles of Clinical Trials Remain Powerful
Authors: Robert M. Califf
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pyogenic granuloma of the colon
Authors: A. Thibault, A. Lavergne-Slove, P. Soyer, V. Ozenne, P. Marteau, X. Dray
Journal: Endoscopy (2012)

A 54-year-old man who had been suffering from abdominal pain for several months was admitted for minor rectal bleeding. Physical examination found mild abdominal tenderness in the left upper quadrant, and was otherwise unremarkable. The following laboratory indices were found: hemoglobin rate, 13.9 g/dL; white blood cell count, 14 000/mm3; C-reactive protein, 12 mg/dL. Colonoscopy revealed a pedunculated polyp of the descending colon with a short, wide stalk and a 20-mm large white-coated head with superficial ulceration ([Fig. 1]). The surrounding mucosa displayed a pseudopolypoid pattern, for which biopsies demonstrated non-specific inflammation. A clip was placed as a landmark before a 64-section computed tomography (CT) scan was undertaken. CT scan showed segmental colitis and hyperenhancement of the polyp ([Fig. 2]). Snare polypectomy was performed. Pathological examination showed a proliferation of capillaries in a lobular arrangement that extended to the depth of the stalk ([Fig. 3] and [Fig. 4]). A diagnosis of pyogenic granuloma was upheld.
Use of the Urologic Resectoscope in Rectal Pathology
Authors: J. Gaya, A. Obrador, M. Ozonas, E. de Sala
Journal: Endoscopy (1983)

We have resected five sessile polyps and treated rectal hemorrhage using the urologic resectoscope that operates in an aqueous solution. It is our belief that working in an aqueous environment can avoid some of the drawbacks of the standard technique in an air environment. We think that this is a useful technique in digestive endoscopy with precise indications and promising future development.
Radiation Therapy and the Geriatric Oncology Patient
Authors: Jean-Claude Horiot
Journal: Journal of Clinical Oncology (2007)

Delivering radiotherapy to the geriatric cancer patient raises several questions: Are there objective reasons to consider the elderly population as potentially more vulnerable to radiation therapy than younger people? In practice, how are geriatric patients treated when radiotherapy is indicated? Recent data from French tumor registries on rectal cancers are reviewed to illustrate the evolution of the practices during a 20-year period up to 2000. Is there a changing landscape in radiotherapy research protocols in the elderly? Thirty-one European Organisation for Research and Treatment of Cancer (Brussels, Belgium) radiotherapy protocols are analyzed regarding compliance to the 1996 recommendation of having no upper age limit when other eligibility factors are fulfilled. To conclude, specific recommendations for optimal radiotherapeutic management of geriatric patients are made for some common cancers in the elderly.
Pure ocular mucous membrane pemphigoid reactive with both β4 integrin and the BP180 C-terminal domain
Authors: G. Solano-López, M.J. Concha-Garzón, J. Sánchez-Pérez, Y. Hirako, X. Li, N. Ishii, T. Hashimoto, E. Daudén
Journal: British Journal of Dermatology (2014)

Journal Article Pure ocular mucous membrane pemphigoid reactive with both β4 integrin and the BP180 C‐terminal domain Get access G. Solano‐López, G. Solano‐López Department of Dermatology Hospital Universitario de la Princesa Madrid 28006 Spain Search for other works by this author on: Oxford Academic Google Scholar M.J. Concha‐Garzón, M.J. Concha‐Garzón Department of Dermatology Hospital Universitario de la Princesa Madrid 28006 Spain Search for other works by this author on: Oxford Academic Google Scholar J. Sánchez‐Pérez, J. Sánchez‐Pérez Department of Dermatology Hospital Universitario de la Princesa Madrid 28006 Spain Search for other works by this author on: Oxford Academic Google Scholar Y. Hirako, Y. Hirako Department of Natural Science Informatics School of Informatics and Science Nagoya University Nagoya Aichi Japan Search for other works by this author on: Oxford Academic Google Scholar X. Li, X. Li Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka Japan Search for other works by this author on: Oxford Academic Google Scholar N. Ishii, N. Ishii Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hashimoto, T. Hashimoto Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka Japan Search for other works by this author on: Oxford Academic Google Scholar E. Daudén E. Daudén Department of Dermatology Hospital Universitario de la Princesa Madrid 28006 Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 2, 1 February 2015, Pages 542–544, https://doi.org/10.1111/bjd.13290 Published: 01 February 2015
Hepatitis B Virus Transmission Between Heterosexuals
Authors: Gerard E. Mullin, Arthur L. Sheppell
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The article by Alter et al<sup>1</sup>links increased risk of transmission of hepatitis B virus (HBV) with increased heterosexual activity. Dr Alter has stated elsewhere (<i>New York Times</i>, Sept 16, 1986) that this study may provide a model for predicting the transmission of the acquired immunodeficiency syndrome (AIDS) in the heterosexual population. The acquired immunodeficiency syndrome has frequently been compared with HBV-induced hepatitis with respect to viral etiology, mode of transmission, and populations at risk. In fact, prior to the isolation of the human immunodeficiency virus (HIV), HBV had been proposed as an etiologic agent or a contributory agent in the development of AIDS.<sup>2</sup>Certainly, the interrelationship of these two distinct viral illnesses is complex, but there seems to be evidence that their respective effects on the immune system may alter the natural histories of each disease. Host factors may play a role in this
UK government fails its first test on public health
Authors: T. Delamothe
Journal: BMJ (1997)

As we went to press Tessa Jowell, Britain's minister for public health, was preparing to appear before the Commons European legislation select committee. Her difficult brief was to explain why the government had reneged on its promise to ban tobacco advertising by exempting Formula One motor racing.1 Given that such an exemption jeopardises the best chance yet of getting European health ministers to agree to ban tobacco advertising throughout the European Union, she may find the going tough.

The government's only honourable exit from this debacle is to admit that it goofed (as the prime minister has begun to do—though so far only over presentational matters) and attend next month's meeting of European health ministers determined to support a total ban on tobacco advertising. If Ms Jowell continues to support the unsupportable line that …
Experts defend NICE against attack by US politician
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

Commentators have defended the work of the National Institute for Health and Clinical Excellence (NICE) after a newspaper claimed that the White House was backing large drug companies in their efforts to have unrestricted access to the NHS as part of a free market. 

The US deputy secretary for health, Alex Azar, who met officials in London last week, said that mechanisms such those of NICE for rationing drugs to keep costs down stifle innovation, the article in the Guardian reported (14 Nov, p 1). Allowing all new drugs to be used in the NHS would result in drug companies “fighting it out” on price, he said, which would cut drug costs. 

The drug companies have themselves repeatedly lobbied ministers for NICE to be reformed and to allow their drugs to be made available on the NHS more quickly. 

In his interview with the Guardian Mr Azar said he recognised that healthcare costs in all rich nations were rising while budgets were shrinking as the population aged. “On the other side we have to focus on long-term …
The Sense of Smell in Man — Its Physiologic Basis
Authors: Robert A. Schneider
Journal: New England Journal of Medicine (1967)

THE sense of smell has received scant attention in contrast to other special senses. Although it may be crucial to survival in animals, it seems less critical for man. Lack of knowledge stems, in part, from difficulties encountered in the study of olfaction; the end-organ is relatively inaccessible, and the stimulus is difficult to quantify.Pathways for SmellThe olfactory membrane occupies a position high in the nasal cavity out of the mainstream of air flow (Fig. 1). Because olfactory receptors are located in a small cavity surrounded by erectile nasal mucous membrane, the quantity, temperature and moisture of inspired . . .
Monocyte chemotactic protein-1 in the migration of differentiated leukaemic cells toward alveolar epithelial cells
Authors: W-H. Tsai, C-H. Shih, C-C. Lin, C-K. Ho, F-C. Hsu, H-C. Hsu
Journal: European Respiratory Journal (2008)

All-trans retinoic acid (ATRA) can induce acute respiratory distress syndrome in patients with acute promyelocytic leukaemia (APL). The current study investigated the role of monocyte chemotactic protein (MCP)-1 in the chemotactic transmigration of ATRA-treated NB4 (ATRA-NB4) APL cells toward A549 alveolar epithelial cells. NB4 and A549 cells were separately cultured with ATRA and/or dexamethasone (DEX). ATRA-NB4 cells were then placed in an upper insert and co-incubated with A549 cells or their conditioned medium (CM) located in a lower plate to test their transmigration activity. ATRA stimulated NB4 cells to transmigrate toward the A549 cells. The secretion of MCP-1 was enhanced by ATRA treatment in both A549 and NB4 cells. The binding assay demonstrated that ATRA-NB4 cells bound MCP-1. Pre-treatment of both CM-A549 cells with antibodies against MCP-1 and of ATRA-NB4 cells with antibodies against MCP-1 receptors reduced ATRA-NB4 cell transmigration. DEX did not suppress MCP-1 secretion and transmigration in ATRA-NB4 cells, although when applied to A549 cells, MCP-1 secretion was suppressed and ATRA-NB4 cell transmigration was attenuated. Monocyte chemotactic protein-1 secreted from alveolar epithelial cells plays an important role in the cell–cell interaction involved in the chemotactic transmigration of all-trans retinoic acid-treated acute promyelocytic leukaemia cells toward alveolar epithelial cells.
Establishing a Murine Pancreatic Cancer CaSm Model: Up-regulation of CaSm Is Required for the Transformed Phenotype of Murine Pancreatic Adenocarcinoma
Authors: Yan Yan, Semyon Rubinchik, Patricia M. Watson, Joseph R. Kelley, Melissa M. Fraser, April L. Wood, Jian-yun Dong, William E. Gillanders, Alice M. Boylan, Dennis K. Watson, David J. Cole
Journal: Molecular Therapy (2004)

We have recently shown that the cancer-associated Sm-like protein (CaSm) is overexpressed in human pancreatic adenocarcinoma (PC). However, the role of CaSm in the process of neoplastic transformation remains unclear. To define further the role of CaSm in PC transformation, we have established a murine model based on the murine pancreatic cancer cell lines Panc02 and Panc03. CaSm is overexpressed in the aggressive Panc02 cells and expressed at much lower levels in the more indolent Panc03 cells. Up-regulation of CaSm in Panc03 cells increased in vitro proliferation and anchorage-independent growth and promoted subcutaneous tumor establishment and growth in syngeneic mice. Conversely, adenoviral down-regulation of CaSm in Panc02 led to significant inhibition of cellular proliferation and anchorage-independent growth in vitro and complete abolition of tumor growth and metastasis in vivo. Up-regulation of CaSm in NIH3T3 resulted in loss of contact inhibition and increased soft agar colony formation in vitro. The requirement for CaSm overexpression for neoplastic transformation confirms the concept that CaSm is a critical oncogene and potential target for molecular intervention. Furthermore, establishment of the murine clinically relevant model of pancreatic metastases provides a framework for the generation of preclinical data to support the development of novel molecular therapies targeting CaSm.
LONGITUDINAL STRAIN ASSESSED BY 2D SPECKLE TRACKING ECHOCARDIOGRAPHY PREDICTS MICROVASCULAR OBSTRUCTION IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION
Authors: Zhiqing Qiao, Jing Ping Sun, Heng Ge, Alex Lee, Jun Pu, hang zhao, Jun Wang, Ben He, Xuedong Shen
Journal: Journal of the American College of Cardiology (2014)
Inflammatory syndrome with liver adenomatosis: the beneficial effects of surgical management
Authors: A S. Cunha, J F Blanc, E Lazaro, L Mellottee, B L. Bail, J Zucman-Rossi, C Balabaud, P Bioulac-Sage
Journal: Gut (2007)

We report a case of a patient with an inflammatory syndrome cured after resection of an adenoma. A 33-year-old woman was admitted to the department of internal medicine in May 2004 for invalidating pain in the spinal cord in the context of an inflammatory syndrome. The patient had been on oral contraceptives (Adepal) for the past 16 years. The inflammatory syndrome involved fever (37.4–38°C), anaemia, C reactive protein 90 mg/l, fibrinogen 7 g/l, sedimentation rate 106 mm and haptoblobin 2.9 g/l. Investigations for infectious, viral, systemic, hormonal and haematological disorders were all negative.

Liver function tests showed abnormally high levels of alkaline phosphatase (×3N), γ-glutamyltransferase (×2N), and alanine aminotransferase (×1.5N). Liver ultrasound scan showed two nodules in the right lobe (12 and 4 cm across), which was confirmed by magnetic resonance imaging (MRI), and three additional 1-cm-nodules in the same lobe. A right …
Disturbances of Urination after Administration of Certain Newer Drugs
Authors: Philip Krainin, Charles Ney
Journal: New England Journal of Medicine (1955)

RECENT experience with a number of the newer drugs has demonstrated the need for an awareness of their potentially deleterious effects on micturition. In some cases the complications, not truly toxic in nature, were entirely due to side effects—that is, pharmacologic evidence that the drug was operating in organs and systems where these manifestations were unlooked for or undesirable. In other cases the urinary complications were mechanical in origin. The disturbances have varied in degree from mild difficulty in urination to complete urinary retention.It is the purpose of this paper to discuss ganglionic-blocking agents, hydralazine, anticholinergic drugs, antihistamines, isonicotinic . . .