The Nature of Joint Involvement in Progressive Systemic Sclerosis (Diffuse Scleroderma)
Authors: GERALD P. RODNAN
Journal: Annals of Internal Medicine (1962)

Article1 March 1962The Nature of Joint Involvement in Progressive Systemic Sclerosis (Diffuse Scleroderma)Clinical Study and Pathologic Examination of Synovium in Twenty-nine PatientsGERALD P. RODNAN, M.D.GERALD P. RODNAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-3-422 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInvolvement of the joints in progressive systemic sclerosis was first noted in 1847 by Forget who described a 33-year-old woman whose initial symptoms were pain and swelling of many joints and whose "wrists still bore the traces of leeches and of cupping glasses" (1). The great frequency of these and other joint complaints at the onset or during the course of scleroderma was soon recognized and interpreted variously as indicative of rheumatism or simply related to change in the overlying skin. In 1896 Dercum secured roentgenograms of the hands of a patient with scleroderma and noted narrowing of the proximal...References1. FORGET C: Mémoire sur le chorionitis ou la sclérosténose cutanée (maladie non décrite par les auteurs). Gaz. Méd. Strasbourg 7: 200, 1847. Google Scholar2. DERCUM FX: (a) Scleroderma. J. Nerv. Ment. Dis. 21: 431, 1896; (b) On scleroderma and chronic rheumatoid arthritis. Ibid. 25: 703, 1898. CrossrefGoogle Scholar3. OSLER W: On diffuse scleroderma; with special reference to diagnosis and the use of thyroid gland extract. J. Cutan. Genito-urin. Dis. 16: 49 and 127, 1898. Google Scholar4. ADRIANROEDERER CJ: Les arthropathies au cours de la sclerodermie. Ann. Derm. Syph. (Par.) 1: 299, 341, and 395, 1920. Google Scholar5. O'LEARYNOMLAND PAK: A clinical study of one hundred and three cases of scleroderma. Amer. J. Med. Sci. 180: 95, 1930. CrossrefGoogle Scholar6. BlEGELMANGOLDNERBAYLES PMFTB: Progressive systemic sclerosis (scleroderma). New Engl. J. 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HARPER RA: The radiological manifestations of diffuse systemic sclerosis (scleroderma). Proc. Roy. Soc. Med. 46: 512, 1953. MedlineGoogle Scholar20. BOYDPATRICKREEVES JASIRJ: Roentgen changes observed in generalized scleroderma. Report of sixty-three cases. Arch. Intern. Med. 94: 248, 1954. CrossrefGoogle Scholar21. INGRAM JT: Acrosclerosis and systemic sclerosis. Arch. Derm. 77: 79, 1958. CrossrefGoogle Scholar22. BENNETTDALLENBACH GAFD: Synovial membrane changes in disseminated lupus erythematosus; observations of two autopsied cases. Milit. Surg. 109: 531, 1951. CrossrefMedlineGoogle Scholar23. SHULMANKURBANHARVEY LEAKAM: Tendon friction rubs in progressive systemic sclerosis (scleroderma). (Abstract) Arthritis Rheum. 4: 438, 1961. Google Scholar24. ZIFF M: The agglutination reaction in rheumatoid arthritis. J. Chron. Dis. 5: 644, 1957. CrossrefMedlineGoogle Scholar25. KELLGRENBALL JHJ: Clinical significance of the rheumatoid serum factor. Brit. Med. J. 1: 523, 1959. CrossrefMedlineGoogle Scholar26. RODNAN GP: The pathogenesis of progressive systemic sclerosis (diffuse scleroderma) and dermatomyositis. A review of recent evidence indicative of an immunologic abnormality in these disorders, in Inflammation and Diseases of Connective Tissue. A Hahnemann Symposium, ed. by Mills, L. C., Moyer, J. H., W. B. Saunders Company, Philadelphia, 1961, p. 225. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, PennsylvaniaFrom the Department of Medicine, University of Pittsburgh School of Medicine.Supported in part by a special research fellowship, National Heart Institute (HF-5493) and a grant (A-97) from the Health and Research Services Foundation of Allegheny County.Requests for reprints should be addressed to Gerald P. Rodnan, M.D., Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh 13, Pennsylvania. 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WEINBERGER, M.D., F.A.C.P.A review of recent observations and current theories on the etiology and pathogenesis of progressive systemic sclerosis (diffuse scleroderma) 1 March 1962Volume 56, Issue 3Page: 422-439KeywordsHealth services researchHeartInflammationLatexLesionsMetabolic disordersOsteoporosisPatientsRheumatic feverScleroderma Issue Published: 1 March 1962 PDF DownloadLoading ...