tbuckley/cabot-search huggingface dataset:
Patient Autonomy and Clinician Integrity in Treatment Decisions—Reply
Authors: John Lantos
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of acid α-naphthyl acetate esterase activity as a marker of T lymphocytes in benign and neoplastic cutaneous infiltrates
Authors: A.C. CHU, E.W. MORGAN, D.M. MACDONALD
Journal: British Journal of Dermatology (1981)

Activity of the enzyme acid α-naphthyl acetate esterase (ANAE) in T lymphocytes and histiocytes in cutaneous tissue sections of patients with histologically confirmed lichen planus, chronic discoid eczema and mycosis fungoides was compared with results obtained using an in situ immunohistochemical technique employing an antiserum against the human T lymphocyte surface antigen (HTLA). In lichen planus and chronic discoid eczema, most of the cells in the cutaneous infiltrate exhibited both positive ANAE activity and the presence of HTLA. In mycosis fungoides, cells identified as T lymphocytes by the presence of HTLA often showed no ANAE activity. ANAE activity appears to be a useful marker of T lymphocytes in benign cutaneous infiltrates but is less reliable in labelling abnormal T cells.
The Mecholyl Test in Schizophrenia
Authors: JERRY HIGGINS, JUDITH C. PETERSON
Journal: American Journal of Psychiatry (1967)

Reports in the literature on the Mecholyl test suggest that schizophrenics with a marked reaction to Mecholyl tend to be acute cases with good prognoses, demonstrating relatively good adjustment both preceding and during the psychosis. Schizophrenics with a mild Mecholyl reaction tend to be chronic and/or poor prognostic risks and manifest grossly inadequate premorbid as well as current functioning. The authors note conflicting evidence and identify the problem of test reliability as a primary source of ambiguous data.
Epithelial protein lost in neoplasm modulates platelet-derived growth factor–mediated adhesion and motility of mesangial cells
Authors: Haruko Tsurumi, Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Kenji Hayashi, Atsuko Matsunaga, Yuko Kajiho, Shoichiro Kanda, Kenichiro Miura, Takashi Sekine, Akira Oka, Kiyonobu Ishizuka, Shigeru Horita, Motoshi Hattori, Seisuke Hattori, Takashi Igarashi
Journal: Kidney International (2014)
Variations in ultrastructural appearance of Langerhans cells of normal human epidermis
Authors: A.S. Breathnach
Journal: British Journal of Dermatology (1977)

Journal Article Variations in ultrastructural appearance of Langerhans cells of normal human epidermis Get access A.S. Breathnach A.S. Breathnach St Mary's Hospital Medical School, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Page 14, https://doi.org/10.1111/j.1365-2133.1977.tb14295.x Published: 01 December 1977
A True Hermaphrodite Chimera Resulting from Embryo Amalgamation after in Vitro Fertilization
Authors: Lisa Strain, John C.S. Dean, Mark P.R. Hamilton, David T. Bonthron
Journal: New England Journal of Medicine (1998)

High rates of successful pregnancy after in vitro fertilization depend on placing more than one embryo into the mother, a practice resulting in a 30-to-35-fold increase in dizygotic-twin deliveries.1 Increased frequencies of twin-associated anomalies might also therefore be expected. Chimerism, the presence in a single person of cells derived from two or more zygotes, is one such rare anomaly. It is usually ascertained through anomalous blood-grouping results or (for XX/XY chimeras) sex reversal or intersex. We used DNA polymorphisms to investigate a 46,XX/46,XY hermaphrodite conceived by in vitro fertilization. We found not only that the child is a chimera, but . . .
American children to be weaned from hot dogs to bananas
Authors: J Roberts
Journal: BMJ (1994)

Since the second world war American children have grown up eating hamburgers, hot dogs, and chips, most of these eating habits being established by school lunches. But last week the United States Department of Agriculture announced that American schoolchildren were eating too much fat and sodium and too little fibre. It is proposing new rules for school lunches. If they are implemented schoolchildren will dine on low …
Lipopolysaccharide Potentiates the Effect of Hepatocyte Growth Factor upon Replication in Lung, Thyroid, Spleen, and Colon in Rats in Vivo
Authors: Cuihua Gao, Susan Kennedy, Katherine Parker Ponder
Journal: Molecular Therapy (2001)

Induction of replication may potentiate in vivo gene therapy, as some viral vectors only transduce dividing cells. Hepatocyte growth factor (HGF) increases the percentage of replicating hepatocytes to 18-fold that in normal rats, and lipopolysaccharide (LPS) modestly potentiates this effect. In this study, the effect of iv HGF upon replication in other organs was determined. HGF at 10 mg/kg resulted in replication that was ≤3-fold that of normal rats in alveolar and proximal renal tubular cells. HGF alone had no effect upon replication of epithelial cells from the bronchi, thyroid, pancreas, or colon or upon cells from the muscle, pancreatic islets, spleen, blood vessels, or thymus. HGF and LPS at 5 mg/kg resulted in replication that was 9-fold that of normal rats in alveolar cells, 25-fold in bronchial epithelial cells, 4-fold in thyroid epithelial cells, 1.5-fold in the red pulp of the spleen, and 2-fold in colonic epithelial cells. The synergistic effect may be due to the fact that LPS upregulated the HGF receptor c-met in thyroid, spleen, and colon. We conclude that iv administration of HGF alone is relatively specific for inducing hepatocyte replication and would allow selective gene transfer into the liver.
A ROLE FOR MICROPHTHALMIA TRANSCRIPTION FACTOR (MITF) IN CARDIAC PROGENITOR CELL PROLIFERATION AND DIFFERENTIATION
Authors: Jussi Leinonen, Inbal Rachmin, Avishag K. Emanuelov, Hovav Nehushtan, Chaim Lotan, Dan Gilon, Ehud Razin, Sagi Tshori, Ronen Beeri
Journal: Journal of the American College of Cardiology (2012)
Evaluation of peak expiratory flow variability in an adolescent population sample. The Odense Schoolchild Study.
Authors: H C Siersted, H S Hansen, N C Hansen, N Hyldebrandt, G Mostgaard, H Oxhøj
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

The validity of peak expiratory flow (PEF) recordings and the sensitivity of PEF variability indices in asthma and asthma-like conditions were examined in an adolescent population. Recordings from 245 randomly selected subjects and from an additional 181 subjects reporting or considered at risk for developing asthma were analyzed. Subjects recorded PEF twice daily for 2 wk using Mini-Wright meters, completed a symptoms questionnaire, and were tested for airway responsiveness to methacholine. The first three recording days showed significant accumulation of lowest PEF values recorded (41%) and were excluded from further analysis. Among nine PEF variability indices, the Two-lowest%mean (the mean of the two lowest PEF values as a percentage of the period mean) had the best sensitivity for physician-diagnosed asthma (28%). The sensitivity of the methacholine dose-response slope (DRS) was 69%. Combining these indices, a sensitivity of 77% for diagnosed asthma was obtained. Among subjects with asthma-like symptoms but no diagnosis of asthma, 14% had increased Two-lowest%mean and the DRS was increased in 17%, but only 3% were identified by both tests. In conclusion, inhomogeneity of PEF data could be corrected by disregarding the first three recording days. PEF variability indices identified some diagnosed asthmatics, and particularly some symptomatic "nonasthmatics," not identified by the DRS, suggesting that the combined use of these indices might be helpful.
Biomedical Research and Insider Trading
Authors: J R Ferguson
Journal: New England Journal of Medicine (1997)

On April 10, 1997, the Securities and Exchange Commission filed the first case ever brought against a biomedical researcher on the basis of allegations of insider trading.1 The case involved a gastroenterologist at Wayne State University who was the lead investigator in a clinical trial of an experimental antihepatitis drug manufactured by Alpha I Biomedicals.2 The commission charged that the investigator and his wife illegally alerted at least six friends and relatives that the clinical trial had failed to demonstrate the effectiveness of the drug. On the basis of this disclosure, the six people allegedly sold their Alpha I shares . . .
UK regulator to shame companies for misleading advertisements
Authors: Liza Gibson
Journal: BMJ (2005)

The UK drug agency, the Medicines Healthcare Products Regulatory Agency, says it will be “naming and shaming” pharmaceutical companies that produce misleading promotional material. The drug industry will now have to comply with new “tougher” guidance aimed at poor practice.

Companies that regularly breach the guidelines will be subject to a review of their whole advertising portfolio to ensure they meet …
Primary Care Internal Medicine
Authors: Brian J. Bohlmann
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 June 1990Primary Care Internal MedicineBrian J. Bohlmann, MDBrian J. Bohlmann, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-11-884 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I am currently in the third and final year of internal medicine residency and read Lipkin and colleagues' article (1) about the practice of primary care internal medicine with great interest. Fortunately, my training has provided substantial experience with both traditional inpatient medicine and longitudinal outpatient practice; thus, I feel comfortable in both roles.Having spent the last year looking at practice opportunities in internal medicine, I agree with Lipkin and colleagues that much of the medical community seems to be ignorant about primary care internal medicine. Most of the physician recruiters and medical directors with whom...References1. LipkinLevinsonBarker MWR. Primary care internal medicine: a challenging career choice for the 1990s. Ann Intern Med. 1990;112:371-8. LinkGoogle Scholar1. LipkinLevinsonBarker MWR. Primary care internal medicine: a challenging career choice for the 1990s. Ann Intern Med. 1990;112:371-8. LinkGoogle Scholar2. Platt F. What do internists think? [Editorial]. Arch Intern Med. 1989;149:1723-4. CrossrefMedlineGoogle Scholar3. HersheyMcAloonBertram CMD. The new medical practice environment: internists' view of the future. Arch Intern Med. 1989;149:1745-9. CrossrefMedlineGoogle Scholar1. LipkinLevinsonBarker MWR. Primary care internal medicine: a challenging career choice for the 1990s. Ann Intern Med. 1990;112:371-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Marshfield Clinic Marshfield, WI 54449 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1990Volume 112, Issue 11Page: 884-885KeywordsInpatientsOutpatientsResidencyTraditional medicine Issue Published: 1 June 1990 PDF DownloadLoading ...
Der iatrogene Kranke (Die Induzierung und Chronifizierung einer Neurose durch den Arzt)
Authors: A. Jores
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 Der iatrogene Kranke (Die Induzierung und Chronifizierung einer Neurose durch den Arzt) Subject Area: Psychiatry and Psychology A. Jores A. Jores II. Medizinische Universitäts-Klinik und Poliklinik Hamburg-Eppendorf (Direktor: Prof. Dr. A. Jores) Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (2-4): 142–152. https://doi.org/10.1159/000285886 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation A. Jores; Der iatrogene Kranke (Die Induzierung und Chronifizierung einer Neurose durch den Arzt). Psychother Psychosom 31 December 1967; 15 (2-4): 142–152. https://doi.org/10.1159/000285886 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
The Radiology of Complications in Medical Practice
Authors: Richard M. Gore
Journal: JAMA (1984)

Concomitant with the recent proliferation of diagnostic and therapeutic modalities has come a dramatic increase in the number and severity of iatrogenic complications. Indeed, approximately 20% to 25% of hospitalized patients experience adverse reactions to diagnostic and therapeutic procedures, severely testing the venerable dictum<i>primum non nocere</i>—first do no harm. This excellent textbook presents a comprehensive review of the spectrum of commonly encountered iatrogenic complications and discusses not only their radio-graphical and clinical diagnosis, but presents a perspective of the underlying pathophysiology and, in some cases, treatment options. This practical work is divided into eight chapters, six of which discuss complications of a certain organ system: the nervous system, respiratory tract and mediastinum, cardiovascular system, gastrointestinal tract, genitourinary system, and the musculoskeletal system; two others deal with special pediatric complications and medical-legal issues. The chapter on complications of the respiratory tract and mediastimum, written by the editor, is a
Open Healing of Tuberculous Cavities
Authors: T. M. Wilson, L. Doyle, M. P. Gardiner
Journal: BMJ (1958)

BEDIC'wURNrL 87 whose lung function is already impaired is more likely to cause respiratory insufficiency in the immediate postoperative period.It is suggested that any such patient should have the pulmonary function assessed before opera- tion so that measures may be taken to combat any post- operative anoxia which may arise. SummaryMeasurements of the total lung capacity and its subdivisions were made on 26 male patients.Significant reductions occurred in the total lung capacity, inspiratory capacity, expiratory reserve volume, vital capacity, and functional residual capacity after abdominal operations, and these changes were more marked after those on the upper abdomen.Possible causes of these changes are briefly considered.We thank Professor J. L. D'Silva for much helpful advice and criticism, and the surgical staff of the London Hospital for per- mission to study their patients.Figs.
Cancer Prevention: A Global Perspective
Authors: Bernard W. Stewart, Alan S. Coates
Journal: Journal of Clinical Oncology (2005)

This review will be restricted to measures aimed at primary prevention of cancer; reduction of the death rate through screening will not be covered. In many instances, cancer prevention is just one outcome of the benefits of good health practices, which may also benefit cardiovascular, lung, infectious, and metabolic diseases. Thus, reducing tobacco smoking will bring benefits in heart disease, neonatal and maternal health, stroke, and peripheral vascular disease as well as a variety of cancers, while dietary advice appropriate to cancer risk reduction will bring benefits in diabetes, stroke, kidney, and heart disease.
Once daily Asacol
Authors: A. B. Hawthorne, R. Stenson, D. Gillespie, E. T. Swarbrick, A. Dhar, K. C. Kapur, K. Hood, C. S. Probert
Journal: Gut (2011)

<h3>Introduction</h3> Mesalazine has traditionally been administered in divided doses, but there is emerging evidence that once daily dosing is no less effective and may improve treatment adherence. <h3>Methods</h3> The Colitis Once Daily Asacol® (CODA) study was designed to assess the efficacy and safety of once daily dosing with Asacol® 2.4 g given as 3 × 800 mg tablets (OD) in comparison with three times daily dosing (one 800 mg tablet three times daily) (TDS). Adult UC patients taking mesalazine or sulphasalazine in remission for &gt;4 weeks and &lt;2 years were randomised (investigator-blind) to OD or TDS dosing. The primary end-point was the difference between groups in relapse rates over one year. Relapse was defined as typical symptoms of relapse with a Baron sigmoidoscopy score of 2 or 3. With estimated relapse rate of 20–30%, and a meaningful difference of 10% between groups, 250 patients were required to demonstrate non-inferiority with one-sided α of 5% and 1-β of 80%. Non-inferiority would be concluded if the upper limit of the 95% confidence interval (CI) for the difference between treatments was &lt;10% for both per protocol (PP) and intention to treat (ITT) population. (For ITT analysis, missing data was imputed as relapse.) <h3>Results</h3> 213 patients were recruited in 32 UK centres. Groups were well matched. There was no difference in adverse events between OD and TDS groups. Primary analysis confirmed non-inferiority of once-daily dosing. In a secondary analysis, (table 1) both ITT and per protocol (PP) populations demonstrated superiority of OD versus TDS dosing which was statistically significant. A multivariable analysis of baseline factors predicting relapse will be presented. Self-reported adherence at 12 months or relapse was &gt;90% in 97% of patients (OD group) and 85% (TDS group). When asked how easy it was to remember to take tablets, it was reported to be very or fairly easy in 98% (OD group) versus 73% (TDS group). <h3>Conclusion</h3> Once daily dosing with Asacol<sup>™</sup> 2.4 g is as safe and effective as three times daily dosing, and secondary analysis confirmed significantly reduced relapse rates. The benefit was, however, clinically borderline and may relate to ease of adherence.
A man with dilated veins on his upper chest
Authors: S. P. Wallis, D. Mistry, A. P. Coatesworth, M. Porte
Journal: BMJ (2011)

A 77 year old man was referred by his general practitioner because of skin changes over his anterior chest wall (fig 1⇓). These skin changes had been present for several years and were not worsening. He had no history of dysphagia, voice change, shortness of breath, neck pain, neck swelling, or weight loss. His medical history included a goitre treated by radioiodine eight years earlier. He had no other medical history of note, he was not taking any drugs, and he did not smoke. 



On examination he appeared well with no stridor. He was haemodynamically normal. Fullness was seen in the lower neck but no discrete lump was palpated. Numerous dilated veins were seen over the upper anterior chest wall on both sides, although they were more pronounced on the right side. He had no cervical lymphadenopathy or cachexia.

Blood tests showed normal thyroid function and thyroid antibodies were not raised. Computed tomography was performed (fig 2⇓). Fine needle aspiration was not performed.





### 1 What changes are seen in the photograph? 

#### Short answer

Chronic venous obstruction by a large goitre has led to numerous chest wall collaterals. The right external jugular vein is also dilated. 

#### Long answer

A large …
Development of Acromegaly After Pituitary Apoplexy
Authors: Renato Candrina
Journal: JAMA (1986)

THE OCCURRENCE of partial necrosis of a pituitary adenoma is a wellknown phenomenon, originally observed by Bleibtreu<sup>1</sup>in a patient with acromegaly. It has been aptly termed<i>pituitary apoplexy</i><sup>2</sup>and has been reported to take place in approximately 10% of affected patients.<sup>3,4</sup>Its occurrence in acromegalic patients has been recorded more than 40 times, and clinical signs of acromegaly were always present beforehand.<sup>4-8</sup>An apparent spontaneous cure of acromegaly, with remission of acromegalic features after the apoplectic episode, occurs frequently,<sup>6,8</sup>but a recurrence of acromegaly, after a long period of clinical inactivity of disease following an episode of pituitary apoplexy, has also been described.<sup>7</sup> We describe a young woman who presented after the spontaneous occurrence of pituitary apoplexy and had had a previously unsuspected, endocrinologically silent pituitary tumor excised by transsphenoidal approach. Pituitary functions partially recovered, but three years later she experienced the recurrence