Metoclopramide-Induced Agranulocytosis
Authors: ROGER L. HARVEY
Journal: Annals of Internal Medicine (1988)

Brief Reports1 February 1988Metoclopramide-Induced AgranulocytosisROGER L. HARVEY, D.O., MICHAEL J. LUZAR, M.D.ROGER L. HARVEY, D.O.Search for more papers by this author, MICHAEL J. LUZAR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-2-214 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAdverse side effects occur in up to 20% of patients receiving metoclopramide treatment (Reglan, A.H. Robbins Co., Richmond, Virginia) (1). Agranulocytosis has not been described previously. Two unpublished reports suggest metoclopramide may have caused agranulocytosis (Board A, A.H. Robbins Co., Personal communication). The first case involved the use of metoclopramide and triamterene; the second case involved the use of metoclopramide and acetaminophen. These patients were not rechallenged with metoclopramide or other agents. In several other unpublished reports, patients received multiple drug regimens and no clear causal relationship could be determined. A few patients were rechallenged with metoclopramide without adverse side...References1. ALBIBI R and MCCALLUM R. Metoclopramide: pharmacology and clinical application. Ann Intern Med. 1983;98:86-95. LinkGoogle Scholar2. WINTROBE M, LEE G, and BOGGS D Variations of leukocytes in disease. In: , eds. Clinical Hematology. 8th ed. Philadelphia: Lea & Febiger; 1981:1284-1323. Google Scholar3. PISCIOTTA A and KALDAHL J. Studies on agranulocytosis. IV. Effects of chlorpromazine on nucleic acid synthesis of bone marrow cells in vitro. Blood. 1962;20:364-76. CrossrefMedlineGoogle Scholar4. STARKEBAUM G, DANCEY J, and AREND W. Chronic neutropenia: possible association with Sjögren's Syndrome. J Rheumatol. 1981;8:679-84. MedlineGoogle Scholar5. WIIK A and FABER V. Neutropenia with rheumatoid arthritis [Letter]. N Engl J Med. 1973;289:981-2. CrossrefMedlineGoogle Scholar6. WAUGH D and IBELS L. Malignant scleroderma associated with autoimmune neutropenia. Br Med J. 1980;280:1577-8. CrossrefMedlineGoogle Scholar7. BUDMAN D and STEINBERG A. Hematologic aspects of systemic lupus erythematosus: current concepts. Ann Intern Med. 1977;86:220-9. LinkGoogle Scholar8. BOGGS D. The leukopenic state. In: CECIL RL, WYNGAARDEN JB, SMITH LH JR, eds. Cecil Textbook of Medicine. 17th ed. Philadelphia: W.B. Saunders, 1985:953-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER L. HARVEY, D.O.; MICHAEL J. LUZAR, M.D.Affiliations: Western Reserve Care System Youngstown, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMetoclopramideReversible Severe Neutropenia after CeftriaxoneThe Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug ReactionsThe role of N-oxidation by leukocytes in drug-induced agranulocytosis and other drug hypersensitivity reactionsDrug Metabolism by Leukocytes and Its Role in Drug-Induced Lupus and Other Idiosyncratic Drug ReactionsGastrointestinal drugsMetoclopramide‐induced agranulocytosis 1 February 1988Volume 108, Issue 2Page: 214-215KeywordsDrugsInfectious diseasesPatients ePublished: 1 December 2008 Issue Published: 1 February 1988 PDF downloadLoading ...