Pathology of Fatal Bacterial Endocarditis before and since the Introduction of Antibiotics
Authors: LARKIN M. WILSON
Journal: Annals of Internal Medicine (1963)

Article1 January 1963Pathology of Fatal Bacterial Endocarditis before and since the Introduction of AntibioticsLARKIN M. WILSON, M.D.LARKIN M. WILSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-84 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence, prognosis, and clinical course of many severe bacterial infections have been greatly improved with the development of effective antimicrobial agents. There is well-documented evidence that with these drugs has come a change in bacterial flora within the population, as well as an alteration in the etiologic organisms of several specific infectious entities (1-3).In view of this shift in etiology, it would seem reasonable to ask if there has been a corresponding change in the pathology of the specific infectious diseases since the introduction of antibiotics. Kneeland and Price have shown that the organisms formerly considered to be...References1. FINLANDJONESBARNES MWFMW: Occurrence of serious bacterial infections since introduction of antibacterial agents. JAMA 170: 2188, 1959. CrossrefMedlineGoogle Scholar2. KNEELANDPRICE YKM: Antibiotics and terminal pneumonia. Amer. J. Med. 29: 976, 1960. CrossrefGoogle Scholar3. WILSON L: Unpublished data. Google Scholar4. ALEXANDERLEACHMANORYYOW JKRDEMEM: Comparison of the physiological alterations in pneumonia caused by pneumococci and gram negative bacilli. (Abstract) Amer. J. Med. 25: 110, 1958. CrossrefGoogle Scholar5. ANGRISTMARQUISS AJ: The changing morphologic picture of endocarditis since advent chemotherapy and antibiotic agents. Amer. J. Path. 30: 39, 1954. MedlineGoogle Scholar6. CATESCHRISTIE JERV: Subacute bacterial endocarditis. Review of 442 patients treated in 14 centres appointed by the Penicillin Trials Committee of the Medical Research Council. Quart. J. Med. 20: 93, 1951. MedlineGoogle Scholar7. BRUNSON JG: Coronary embolism in bacterial endocarditis. Amer. J. Path. 29: 689, 1953. MedlineGoogle Scholar8. CORRELLLUBITZLINDERT HLJMMC: Bacterial endocarditis: clinico-pathologic studies of untreated, treated and cured patients. Ann. Intern. Med. 35: 45, 1951. LinkGoogle Scholar9. GOLDBURGHBAERLIEBER HLSMM: Acute bacterial endocarditis of the tricuspid valve. Amer. J. Med. Sci. 204: 319, 1942. CrossrefGoogle Scholar10. PEARCEGUZE MLLB: Some factors affecting prognosis in bacterial endocarditis. Ann. Intern. Med. 55: 270, 1961. LinkGoogle Scholar11. JONES M: Subacute bacterial endocarditis of non-streptococcal etiology. Amer. Heart J. 40: 106, 1950. CrossrefMedlineGoogle Scholar12. DOWLINGLEPPERCALDWELLSPIES HFMERHW: Staphylococcic endocarditis. An analysis of 25 cases treated with antibiotics, together with a review of the recent literature. Medicine 31: 155, 1952. CrossrefMedlineGoogle Scholar13. LEPESCHKIN E: On the relation between the site of valvular involvement in endocarditis and the blood pressure resting on the valve. Amer. J. Med. Sci. 224: 218, 1952. CrossrefGoogle Scholar14. LILLEHEIBOBBVlSSCHER CWJRMB: Endocarditis in dogs. Proc. Soc. Exp. Biol. Med. 75: 9, 1950. CrossrefMedlineGoogle Scholar15. HIGHMANALTLAND BPD: A new method for the production of experimental bacterial endocarditis. Proc. Soc. Exp. Biol. Med. 75: 573, 1950. CrossrefMedlineGoogle Scholar16. BARKER PS: A clinical study of subacute bacterial infection confined to the right side of the heart or the pulmonary artery. Amer. Heart J. 37: 1054, 1949. CrossrefMedlineGoogle Scholar17. MORGANBLAND WLEF: Bacterial endocarditis in the antibiotic era. Circulation 19: 753, 1959. CrossrefMedlineGoogle Scholar18. SHUBINLEVINSONGRIFFITH HDCGC: Endocarditis due to coagulase positive staphylococcus pyogenes var. aureus. JAMA 167: 1218, 1958. CrossrefMedlineGoogle Scholar19. LISANURICCHIOMARINOLIKOFF PJFDJW: Staphylococcal endocarditis. Amer. Heart J. 59: 184, 1960. CrossrefMedlineGoogle Scholar20. WAISBRENABBOUD BAF: Bacteremia due to coagulase positive staphylococcus aureus. Ann. Intern. Med. 52: 643, 1960. LinkGoogle Scholar21. WISESPINK RWW: Clinical studies on staphylococcal septicemia. JAMA 116: 179, 1941. Google Scholar22. SCHIRGERMARTINNICHOLS AWJDR: Micrococcal bacteremia without endocarditis: clinical data and therapeutic considerations in 109 cases. Ann. Intern. Med. 47: 39, 1957. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LARKIN M. WILSON, M.D.Affiliations: El Dorado, ArkansasFrom the Department of Medicine, University Hospitals, Cleveland, Ohio.Requests for reprints should be addressed to Larkin M. Wilson, M.D., 430 South West Avenue, El Dorado, Arkansas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAortic incompetence: A comparative aetiological study of two patient groupsErkrankungen des EndokardsActive infective endocarditis: A clinicopathologic analysis of 137 necrosy patientsInfective endocarditis—1973Left-sided valvular active infective endocarditisInfective endocarditis at the Presbyterian Hospital in New York City from 1938–1967Postmyocardial infarction ventricular septal perforation complicated by bacterial endocarditisPerforation of the normal mitral valve due to staphylococcic endocarditisInfective Endocarditis in the Antibiotic EraEtiology of Bacterial Endocarditis Before and Since the Introduction of AntibioticsLARKIN M. WILSON, M.D. 1 January 1963Volume 58, Issue 1Page: 84-92KeywordsAntibioticsAntimicrobialsBiostatisticsDrugsEndocarditisEtiologyHospital medicineInfectious diseases ePublished: 1 December 2008 Issue Published: 1 January 1963 PDF downloadLoading ...