tbuckley/cabot-search huggingface dataset:
A New Psychology of Men
Authors: David D. Gilmore
Journal: JAMA (1996)

This volume provides a multiauthored synopsis of the current state of profeminist academic men's studies, primarily from a psychological perspective. The chapters are divided among four sections: theory, research, applications, and varieties of masculinity. The last includes ethnic subcultures, cross-cultural comparisons, and forms of homosexuality and bisexuality. An important theory underlying much of the work is Joseph Pleck's gender role strain paradigm, which emphasizes the conflicts and stresses inherent in gender stereotyping and traditional cultural expectations of men, although pointedly ignoring any benefits therein. The theory posits multiple implications for normal and abnormal male psychology, including effects on development of self-esteem, levels of anxiety, traumatic experience of nonconformity to male stereotypes, and development of dysfunction and psychopathology. The chapter by William Pollack is an effort to update psychoanalytic theories of human development taking feminist and new male psychology into account. It is among the more in-depth and balanced in the
ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia
Authors: Julie Rousseau, Vincent Gagné, Malgorzata Labuda, Cyrielle Beaubois, Daniel Sinnett, Caroline Laverdière, Albert Moghrabi, Stephen E. Sallan, Lewis B. Silverman, Donna Neuberg, Jeffery L. Kutok, Maja Krajinovic
Journal: Blood (2011)
Anabolic Steroids and Sports
Authors: Paul S. Salva
Journal: JAMA (1987)

To the Editor.—  It was with great interest that I read the recent MEDICAL NEWS & PERSPECTIVES article reporting on anabolic steroids in which William Taylor, MD, suggests making them controlled substances. 1 One state at least—Texas—has done so. The 70th session of the Texas legislature recently passed a bill (Senate bill 1035) amending Vernon's Texas Civil Statutes article 4476-14 and making 16 anabolic steroids and human growth hormone controlled substances for which triplicate forms will have to be used to prescribe them. The drugs named specifically in the bill are clostebol, dehydrochloromethyltestosterone, ethylestrenol, fluoxymesterone, mesterolone, methandienone, methandrostenolone, methenolone, methyltestosterone, nandrolone, norethandrolone, oxandrolone, oxymesterone, oxymetholone, stanozolol, testosterone, and human growth hormone. Several of these drugs are not approved for use in the United States, but are available in Europe and Mexico.  The bill originated out of concern about evidence that high school and junior high school boys were taking anabolic
Liver xenotransplantation: changes in lipid and lipoprotein concentration after long-term graft survival
Authors: David G Molleví, Eduardo Jaurrieta, Yolanda Ribas, Isabel Hurtado, Teresa Serrano, Neus Gómez, Javier de Oca, Concepció Fiol, Joan Figueras
Journal: Journal of Hepatology (2000)
Abstract 4260: Activation of cancer stem cells in hepatic <i>Pten</i> deficient mice requires liver injury
Authors: Vivian A. Galicia, Gary Kanel, Lina He, Christopher Vendryes, Bangyan L. Stiles
Journal: Cancer Research (2010)

Abstract Cancer stem cells have been identified in solid and aqueous tumors and are defined as “altered” stem cells with the capacity to form tumors. We used the liver specific Pten (phosphatase and tensin homologue deleted on chromosome ten) deletion murine model to investigate the role of hepatic cancer stem cells in vivo. Proliferation of hepatic progenitor cells in other rodent models has been observed as a consequence of chronic liver injury. Pten-null mice demonstrate escalating levels of hepatic injury markers from 6-12M of age. In addition, TUNEL analysis revealed that hepatocytes from mutant mice are undergoing extensive apoptosis relative to control mice. We hypothesize that hepatocyte cell death induced by lipotoxicity promotes progenitor cell proliferation to replace liver parenchyma. We show here that activation of hepatic progenitor cells (oval cells) in this model occurs progressively. In mutant mice hepatic injury is followed by elevated expression of hepatic progenitor cell markers Cytokeratin 19 (CK 19), Epithelial cell adhesion molecule (EpCAM), α-fetoprotein (AFP) as well as activation of the Wnt/β-Catenin signaling pathway. Furthermore, we report that liver specific Pten-null mice develop both cholangiocellular carcinoma (CC) and hepatocellular carcinoma (HCC) by 12-15 months of age. Collectively these results suggest that liver tumors in this model arise from hepatic progenitor cells. Our studies also demonstrate that when hepatic injury is attenuated tumor onset is significantly delayed, highlighting the relevance of hepatic injury to progenitor cell induced carcinogenesis. In addition, we show that reactive oxygen species (ROS) is the likely molecular mediator for hepatocyte cell death. This study presents in vivo evidence for the contribution of hepatic injury to progenitor cell mediated liver tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4260.
HLA-DR antigen expression on keratinocytes in highly inflamed parts of psoriatic lesions
Authors: T. TERUI, S. AIBA, T. KATO, T. TANAKA, H. TAGAMI
Journal: British Journal of Dermatology (1987)

We have investigated the immunoperoxidase staining pattern in the epidermis and dermal infiltrates of highly inflamed portions of psoriatic lesions, selecting for biopsy early pinpoint lesions or margins of active plaque lesions. We found positive intercellular staining for HLA‐DR antigens in localized areas of the epidermis in about half of the patients tested. In contrast, OKT6 antigen was found only on the dendritic cells in the epidermis and dermis in all cases. These findings support the hypothesis that an active cellular immune reaction involving the epidermis, possibly associated with the expression of HLA‐DR antigens on keratinocytes, occurs in the highly inflamed areas of psoriatic lesions, particularly in early pinpoint lesions or at the edges of spreading plaque lesions.
Regulation of sensitivity in vertebrate rod photoreceptors by calcium
Authors: Yiannis Koutalos, King-Wai Yau
Journal: Trends in Neurosciences (1996)

Over the past decade and a half, there have been great advances in our understanding of how light is transduced into electrical signals by the retina; rod and cone photoreceptors in vertebrates. One essential feature of these sensory neurons is their ability to adapt to background illumination, which allows them to function over a broad range of light intensities. This adaptatio appears to arise mostly from negative feedback on phototransduction that is mediated by calcium ions. Recent work has suggested that this feedback is fairly complex, and involves several pathways directed at different components of phototransduction. From direct measurements of these feedback pathways in rods, it is possible to evaluate their relative contributions to the overall sensitivity of the cell. At the same time, these feedback mechanisms, as currently known, appear to be sufficient for explaining the change in sensitivity of rods during adaptation to light.
Ultrasonography of Digestive Diseases
Authors: Donald L. King
Journal: JAMA (1982)

The accumulation of years of experience and many interesting cases are presented in this survey of ultrasonography of the liver, biliary system, and pancreas. An introductory section of 70 pages deals with basic principles of ultrasonography and reviews the sonographic appearance of the pertinent anatomy. Thereafter follow sections on the liver, biliary tract, and pancreas. The author also includes a 35-page section on the spleen and concludes with four pages of practical advice dealing with diagnostic policy, selection of an ultrasonic instrument, and practical training. In a text of this type, illustrations are of paramount importance, and the author presents a total of 1,821. Most of these have been made with grayscale static contact scanners (B-scanners) and are thus of reasonably good quality. A few bistable scans and some real-time scans are also included. That the latest and best-quality images are not presented is inevitable, given the rapid advance of
Platelets, Petechiae, and Preservation of the Vascular Wall
Authors: Ralph L. Nachman, Shahin Rafii
Journal: New England Journal of Medicine (2008)

This review concerns functional contacts between platelets and endothelial cells, with emphasis on the maintenance of vascular integrity by proangiogenic cytokines and growth factors released by platelets. These molecules bind to receptors on the surface of endothelial cells, thereby stabilizing the vascular-endothelium cadherin complex.
Doppler-echocardiographic parameters of left ventricular diastolic function in patients with mild arterial hypertension
Authors: C.M. Schannwell, F.C. Schoebel, M. Badlian, R. Marx, T.W. Jax, G. Plehn, M. Leschke, B.E. Strauer
Journal: Journal of the American College of Cardiology (1998)
Evaluation of endoscopic-ultrasound-guided celiac ganglion irradiation with iodine-125 seeds: a pilot study in a porcine model
Authors: K. Wang, Z. Jin, Y. Du, J. Chen, X. Zhan, L. Wang, Z. Li, D. Zou, Y. Liu
Journal: Endoscopy (2009)

Background and study aims: Implantation of iodine-125 (125I) seeds under the guidance of endoscopic ultrasonography (EUS) has been proved to be a safe alternative treatment option for advanced pancreatic cancer. The main purpose of this study was to evaluate the feasibility and safety of EUS-guided radiation of the celiac ganglia with125I seeds in a porcine model.
Peripheral Ramification of the Cardiac Conducting System
Authors: WILLIAM G. ESMOND, G. ALLEN MOULTON, R. ADAMS COWLEY, SAFUH ATTAR, EMIL BLAIR
Journal: Circulation (1963)

The study of the peripheral distribution of the right bundle branch in bovine, dog's, goat's, lamb's, and human hearts demonstrates an anatomical basis for the production of varying degrees of right bundle-branch block on operative incision of the anterior wall of the right ventricle. The left branch of the cardiac conducting system, with its transventricular cavity conducting bundles to the papillary muscles and the ventricular wall in bovine, dog's, goat's, lamb's, and human hearts, offers an anatomical basis for varying degrees of disturbance in left ventricular conduction due to operative incision or instrumentation in the left ventricle. Comparative anatomical studies in man and animals show conducting fibers which traverse the ventricular cavities in structures previously termed pseudotendons or false chords. In man, the existence of these transventricular cavity conducting bundles has not been emphasized, probably because of the traditional methods of opening the heart at autopsy. The combined electrocardiographic and anatomical concepts provide a useful background for caution in open-heart operation, lest stretching during manipulative procedures or cutting these peripheral conducting bundles produces irrevocable conduction-damage.
Phase 0 Clinical Trials: An Answer to Drug Development Stagnation?
Authors: Patricia M. LoRusso
Journal: Journal of Clinical Oncology (2009)

action, pharmacology, bioavailability, pharmacodynamics, and metabolic microdose assessments. These studies of novel agents expose a small number of patients (perhaps 10 or fewer) to a limited duration (eg, 7 days or less) and dose (in the range of one 100th of the dose required to yield a pharmacologic effect of the test substance with a maximum dose of 100 g). 3 They are conducted before the traditional phase I dose-escalation safety and tolerance studies. By not having the traditional phase I objectives of toxicity and dose finding, phase 0 studies can be conducted early in the development process and are actually considered more of a discovery, rather than development, tool. In early 2006, the FDA published “A Guidance for Industry, Investigators, and Reviewers for Exploratory IND Studies” as part of the agency’s critical path initiative to streamline drug development and improve the understanding of drugs early in the clinical process. 3 There must be several considerations before initiating a phase 0
156 Proposal of a novel meld score adjustment for HCC patients waiting for liver transplantation
Authors: E. Piscaglia, V. Camaggi, M. Ravaioli, G.L. Grazie, M. Zanello, S. Leonie, M.G. Mirarchi, G. Ballardini, A.D. Pinna, L. Bolondi
Journal: Journal of Hepatology (2006)
Technetium-99m MDP Activity in Unsuspected Necrotizing Fasciitis
Authors: NEAL M. LISANN, DAVID F. YANKELEVITZ, JOSEPH CASTRONUOVO, BELUR CHANDRAMOULY
Journal: Clinical Nuclear Medicine (1986)

A bone image on a 25-year-old woman presenting with fever, elevated white count, and right hip pain, demonstrated radionuclide uptake in the fascia lata of the thigh and its tensor muscle.
PHENYLBUTAZONE (BUTAZOLIDIN®) IN RHEUMATOID ARTHRITIS AND GOUT
Authors: William C. Kuzell
Journal: JAMA (1952)

Phenylbutazone (butazolidin®) is one of a group of pyrazole derivatives developed by the chemists of the J. R. Geigy Co., of Basel, Switzerland, in an attempt to find compounds with pharmacologie properties similar to aminopyrine but without its toxicity (see accompanying figure). Many clinical trials have been conducted in Switzerland and Germany, with a combination of aminopyrine and phenylbutazone in equal parts (the mixture is known as irgapyrin® in Europe and butapyrin® in this country.<sup>1</sup>) These studies were initiated since phenylbutazone was found to promote the solubility of the relatively insoluble aminopyrine, thus permitting its parenteral use. There have been no reports of extensive clinical trials of phenylbutazone alone, whereas the clinical effects and toxicity of aminopyrine are well known. Since the antirheumatic properties of the mixture have been so favorable, it was desirable to evaluate phenylbutazone separately. Considerable pharmacologic investigation has been reported. Wilhelmi<sup>1a</sup>demonstrated that phenylbutazone
Prognostic implications of the European consensus for grading of bone marrow fibrosis in chronic idiopathic myelofibrosis
Authors: Claudia Vener, Nicola Stefano Fracchiolla, Umberto Gianelli, Rossella Calori, Franca Radaelli, Alessandra Iurlo, Sabrina Caberlon, Giancarla Gerli, Leonardo Boiocchi, Giorgio Lambertenghi Deliliers
Journal: Blood (2007)
PHARMACY IN MEDICAL SCHOOLS.
Authors: HENRY PARR HYNSON
Journal: JAMA (1896)

I am led to present a paper upon the teaching of pharmacy in medical colleges for somewhat selfish reasons. This selfishess is not, however, that of the individual but is the kind which seems laudable in a loyal member of the pharmaceutic brotherhood. From the standpoint of the pharmacist, I believe a better knowledge of pharmacy, its truths, laws and practices would be greatly advantageous to medical men. This seems but a logical conclusion, arrived at through and by the acknowledged principle which makes the best and most thorough knowledge of a person, a thing or a theory, the only proper quality for justly and fully estimating the value of any of these. Does this not bring to a number of my honest hearers on "the other side of the house" the question, Am I in a position to do justice to this profession? Or, as I would rather have
Alaskan Voyage 1881-1883
Authors: William R. Barclay
Journal: JAMA (1979)

Between 1881 and 1883, Johan Adrian Jacobsen journeyed along the coast of British Columbia and Alaska to collect Indian artifacts for the Berlin Museum. This account of his adventures is based on his notes, diary, and sketches and was first published in German in 1884 by Adrian Voldt. This is an exciting portrayal of life on the frontier at the end of the 19th century by an astute observer who describes not only the natives but also the Europeans with whom he came in contact. Travel at that time was extremely hazardous, and on several occasions Jacobsen almost lost his life while making his way by small boats along the coast of Vancouver Island. Of particular interest to physicians are his descriptions of illnesses and injuries that he observed and the manner in which they were handled both by Indian medicine men and by Europeans. The book is illustrated with
Night visiting in general practice.
Authors: P J Hobday
Journal: BMJ (1993)

pictures of identifiable patients unless we have their permission or the permission of their next of kin.In the case of Tony Bland his parents had given permission for the press to reproduce his picture.They will have had their own reasons for taking that decision, but we believe that publishing a picture ofhim adds importantly to the information available in words.Some doctors have never seen a patient in a persistent vegetative state.Another reason for publishing pictures is to distinguish one section of the journal from another.We rarely publish pictures, tables, or graphs in the editorial section, and we do not add pictures to the original papers.We deliberately include them in the news section to give this section a different identity.These pages are designed to look "newsy," which means including pictures.Newspapers carry pictures, and so do journals like Nature, Science, and the Economist.Sometimes these pictures will not be as relevant as we would like.But this problem is experienced by all publications putting together news pages fast.What J K Anand and J W Myles may not understand is that the BMJ is the most general of the world's general medical journals.Few general practitioners read either the Lancet or the New England J7ournal of Medicine, and few doctors
Poland violated human rights of woman who was refused timely access to prenatal tests
Authors: C. Dyer
Journal: BMJ (2011)

OBJECTIVE: To determine the effect of pulse methyprednisolone (PMP; 1000 mg) on the expression of monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha in rheumatoid synovial membrane. METHODS: Seven patients with rheumatoid arthritis (RA) were studied. Arthroscopically-directed synovial biopsies were taken before and 24 hours after treatment with intravenous PMP. Synovial membranes were stained by immunohistochemical techniques with monoclonal antibodies against MCP-1, MIP-1alpha and CD68 (a macrophage marker). Quantitation of staining was performed by computer-assisted color video image analysis. RESULTS: PMP therapy was associated with a rapid (within 24 hours) and substantial decrease in the expression of MCP-1 and MIP-1alpha expression by a mean of 55% (p = 0.05) and 45% (p = 0.03), respectively, with no effect on CD68 expression in the synovial lining layer. There was no significant change in MCP-1, MIP-1alpha or CD68 expression in the synovial sublining. CONCLUSION: PMP therapy rapidly reduces MCP-1 and MIP-1alpha levels in the synovial lining layer without a fall in macrophage numbers. It thus appears that the initial effect of PMP is that of reducing macrophage activation.
Familial multiple nevi flammei
Authors: Pedro Redondo, F.Javier Vázquez-Doval
Journal: Journal of the American Academy of Dermatology (1996)

dominant inheritance; and (4) histologic evidence of dilatation of the horizontal subpapillary vessels.Other familial cases of HBT have been reported.9-11 In addition to scattered telangiectases, some patients had round, macular telangiectatic patches that might be confused with NF.Two other families have recently been described 12,13 with a diagnosis of congenital HBT.In our opinion, based on clinical findings, age at onset, and lack of facial telangiectases, they probably have familial NF.
I. From a Prescriber's Point of View
Authors: T. L. Brunton
Journal: BMJ (1895)

The Scope and Objects of the " British Pharmacopceia."-Redundancies and De,ficiencies .-Solubilityand Compatibility.Prescribing Difficulties and the Increase of Proprietary Pre&pa- rations.-Pills and Granules.-AComplicated Poultice.Dosage.THE announcement that a new edition of the British Pharmacopceia is in preparation naturally leads every one who is interested either in the administration or preparation of medicines to ask what changes are likely to be made in it so as to make it more useful or more convenient.The object of the Pharmacopcia is thus stated in the preface to the edition of 1867."It is intended to afford to the members of the medical profession and those engaged in the preparation of medicines throughout the British Empire, one uniform standard and guide whereby the nature and composition of substances to be used in medicine may be ascertained and determined," From the definition thus given by the Gene- ral Medical Council, it is evident that the scope of the British Pharmacopoeia is very wide indeed, whether we regard the number of practitioners and chemists whom it is in- tended to help, and who must be numbered by tens of thousands, or the extent over which its influence will spread -and this is no less than an empire on which the sun never sets, or the number of people whose health and lives it is intended to safeguard-and these are to be numbered by hundreds of millions.
Transgenic myocardial overexpression of prokineticin receptor-2 (GPR73b) induces hypertrophy and capillary vessel leakage
Authors: K. Urayama, D. B. Dedeoglu, C. Guilini, S. Frantz, G. Ertl, N. Messaddeq, C. G. Nebigil
Journal: Cardiovascular Research (2008)

AimsProkineticins are small secreted bioactive molecules. They exert their biological activity by binding to two G protein-coupled receptors. Previously, we have shown that the overexpression of prokineticin receptor-1 (PKR1) in transgenic (TG) mouse hearts induced neovascularization. Since PKR1 and PKR2 are 85% identical and expressed in cardiovascular tissues, we hypothesized that PKR2 may also contribute to cardiomyocyte growth and vascularization.
Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression
Authors: Kathryn E. Hulse, James E. Norton, Lydia Suh, Qiu Zhong, Mahboobeh Mahdavinia, Patrick Simon, Robert C. Kern, David B. Conley, Rakesh K. Chandra, Bruce K. Tan, Anju T. Peters, Leslie C. Grammer, Kathleen E. Harris, Roderick G. Carter, Atsushi Kato, Robert P. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2013)
Combined One-Stage Coronary Artery and Valvular Surgery
Authors: GIDEON MERIN, GORDON K. DANIELSON, ROBERT B. WALLACE, BARRY D. RUTHERFORD, JAMES R. PLUTH
Journal: Circulation (1973)

Fifty patients underwent correction of one or two valvular lesions with concomitant insertion of one to three aortocoronary vein bypass grafts. Hospital mortality was 14% and late mortality was 10%. Factors influencing operative mortality were: (1) mitral valve replacement after myocardial infarction; (2) complete obstruction of a coronary artery preoperatively; (3) high left ventricular end-diastolic pressure at rest preoperatively in patients with mitral valve disease; and (4) use of a single aortocoronary graft in the presence of multiple-vessel disease. For patients with significant associated valvular and coronary artery disease, combined correction yields results that appear sufficiently encouraging, judged by mortality and follow-up, to warrant its continued use in selected cases.
Gonadal function in men treated for acute leukaemia.
Authors: J Waxman, Y Terry, L H Rees, T A Lister
Journal: BMJ (1983)

Gonadal function was assessed in eight men in remission of leukaemia who had completed treatment eight months to eight years previously. All four men treated for acute myeloid leukaemia had normal sperm counts and motility, compared with only one of the four with acute lymphatic or undifferentiated leukaemia. Hormonal studies indicated that the sterility resulted from gonadal failure rather than pituitary dysfunction after cranial irradiation. These findings are important in the counselling of patients with leukaemia.