Heparin: Adverse Reaction
Authors: RICHARD D. O'TOOLE
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 November 1973Heparin: Adverse ReactionRICHARD D. O'TOOLE, M.D., F.A.C.P.RICHARD D. O'TOOLE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-759_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Within the past year my colleagues and I have administered heparin, 5000 units subcutaneously every 12 hours, to various patients for prophylaxis against phlebothrombosis and pulmonary embolism. During this time I have observed four patients who developed a local allergic reaction at the injection site after 5 to 9 days of treatment. The initial manifestation is local erythema and induration that progresses, if injections are continued, to frank necrosis of the involved skin and subcutaneous tissues—a sequence of events resembling the Arthus phenomenon. Other local physicians and pharmacy nurses have made similar observations.Recently, a middle-aged woman... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine Medford Clinic Medford, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Rare Case of a Large Heparin-Induced Skin Necrosis Requiring Surgical Intervention: a Case ReportBleeding, Heparin-induced thrombocytopenia, and Other adverse reactionsA Rare Case of Mortality Following Heparin-induced Necrotizing Skin Lesions as Thromboprophylaxis After Total Abdominal HysterectomyA mysterious postoperative rashComplications and Adverse Sequelae of SclerotherapyHeparinsHeparin-induced skin necrosisLow Molecular Weight Heparin (LMWH)-Induced Bullous Hemorrhagic DermatosisDusky bullae on the abdomenSkin Necrosis Associated with Thromboprophylaxis after Total Knee ReplacementComplications and Adverse Sequelae of SclerotherapyHeparin-induced thrombocytopenia: a renal perspectiveLOW-MOLECULAR-WEIGHT HEPARIN-INDUCED SKIN NECROSIS: ABOUT 2 CASESANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSComplications and Adverse Sequelae of SclerotherapyWidespread skin necrosis associated with unfractionated heparin therapy in a patient under chronic coumarin anticoagulationHeparinsGeneralised cutaneous necrosis: a complication of low-molecular-weight heparinHypersensitivity to Nadroparin CalciumAdverse Dermatologic Effects of Cardiovascular Drug Therapy: Part IIIIatrogenic Cardiovascular Complications: Part IV: Interventional ProceduresDelayed-type hypersensitivity to subcutaneous enoxaparinLow molecular weight heparin‐induced skin necrosis occurring distant from injection sites and without thrombocytopeniaSkin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndromeSkin Necrosis Associated With Heparin-Induced Thrombocytopenia and ThrombosisSkin necrosis following subcutaneous heparin injectionLocalized reactions to injected therapeutic materials. 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Medical agentsDELAYED CUTANEOUS REACTION TO UNFRACTIONATED HEPARIN, LOW MOLECUALR WEIGHT HEPARIN AND DANAPAROIDCholesterol Crystal Embolization-Associated Renal Failure After Therapy With Recombinant Tissue-Type Plasminogen ActivatorHeparin-induced skin reaction due to two different preparations of low molecular weight heparin (LMWH)Heparin skin necrosis-an important indicator of potentially fatal heparin hypersensitivityDELAYED HYPERSENSITIVITY REACTION TO SUBCUTANEOUS HEPARINEczematous infiltrated plaques to subcutaneous heparin: a type IV allergic reactionHeparin-associated skin necrosis.Heparin-induced thrombocytopenia and arterialthrombosis: Alternative therapiesEczema-like, erythematous, infiltrated plaques: A common side effect of subcutaneous heparin therapyHeparin-dependent in vitro aggregation of normal platelets by plasma of a patient with heparin-induced skin necrosis: specific diagnostic test for a rare side effectPhenomenon of heparin-induced thrombocytopenia associated with skin necrosisPossible Heparin-Inouceo Subcutaneous Necrosis in a CAPO PatientCutaneous Cholesterol Emboli with Infarction Clinically Mimicking Heparin Necrosis —Acral purpura: An unusual sign of coumarin necrosisWarfarin-induced skin necrosisPulmonary thromboembolic diseaseUnusual reaction to subcutaneous heparinCutaneous reactions secondary to heparin injectionsSTUDIES ON THE MEDICAL TREATMENT OF DEEP VEIN THROMBOSISHeparin-Induced Skin NecrosisHeparin‐induced skin reactionHeparin necrosis: An anticoagulant-induced cutaneous infarctLeucocytoclastic Vasculitis and Skin Necrosis Following Subcutaneous Heparin CalciumCurrent status of pulmonary thromboembolic disease: Pathophysiology, diagnosis, prevention, and treatmentSkin necrosis after heparin injection.37 Drugs affecting blood clotting, fibrinolysis and hemostasisDrug AllergySENSITIVITY TO INTRAFAT HEPARIN 1 November 1973Volume 79, Issue 5Page: 759-759KeywordsAdverse reactionsAllergy and immunologyErythemaHeparinNecrosisProphylaxisPulmonary embolism Issue Published: 1 November 1973 PDF DownloadLoading ...