Primary Hepatocellular Carcinoma after Orthotopic Liver Transplantation for Chronic Hepatitis B Infection
Authors: Velimir A. Luketic, Mitchell L. Shiffman, Janice B. McCall, Marc P. Posner, A. Scott Mills, Robert L. Carithers
Journal: Annals of Internal Medicine (1991)

Brief Reports1 February 1991Primary Hepatocellular Carcinoma after Orthotopic Liver Transplantation for Chronic Hepatitis B InfectionVelimir A. Luketic, MD, Mitchell L. Shiffman, MD, Janice B. McCall, MD, Marc P. Posner, MD, A. Scott Mills, Robert L. Carithers Jr., MDVelimir A. Luketic, MDSearch for more papers by this author, Mitchell L. Shiffman, MDSearch for more papers by this author, Janice B. McCall, MDSearch for more papers by this author, Marc P. Posner, MDSearch for more papers by this author, A. Scott MillsSearch for more papers by this author, Robert L. Carithers Jr., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-3-212 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrthotopic liver transplantation is an effective treatment for end-stage liver disease caused by chronic hepatitis B infection. Unfortunately, the new liver becomes reinfected with the virus in nearly all recipients (1). Many patients go on to develop chronic hepatitis B and cirrhosis (2). Because long-standing chronic hepatitis B infection is a risk factor for hepatocellular carcinoma (3, 4),these patients may also be at an increased risk for developing this tumor. We report the first documented case of primary hepatocellular carcinoma developing in the hepatic allograft of a patient with recurrent chronic hepatitis B. In this immunosuppressed patient, tumor developed after...References1. StarzlDemetrisVan Thiel TAD. Liver transplantation (second of two parts). N Engl J Med. 1989;321:1092-9. CrossrefMedlineGoogle Scholar2. CarithersYeeMills RYA. Liver transplantation. In: Gitnick G, ed. Current Hepatology. Chicago: Year Book Medical Publishers; 1990:221-49. Google Scholar3. Rustigi V. Epidemiology of hepatocellular carcinoma. In: DiBisceglie AM, moderator. Hepatocellular carcinoma. Ann Intern Med. 1988;108:390-401. LinkGoogle Scholar4. PopperShafritzHoofnagle HDJ. Relation of the hepatitis B virus carrier state to hepatocellular carcinoma. Hepatology. 1987;7:764-72. CrossrefMedlineGoogle Scholar5. BeasleyHwang RL. Hepatocellular carcinoma and hepatitis B virus. Semin Liver Dis. 1984;4:113-21. CrossrefMedlineGoogle Scholar6. AndersonMurray-Lyon MI. Natural history of the HBsAg carrier. Gut. 1985;26:848-60. CrossrefMedlineGoogle Scholar7. WuLaiLamHo PCKJ. Prednisolone in HBsAg chronic active hepatitis: histologic evaluation in a controlled prospective study. Hepatology. 1982;2:777-83. CrossrefMedlineGoogle Scholar8. PafreyForbesHutchinson PRT. The impact of renal transplantation on the course of hepatitis B liver disease. Transplantation. 1985;39:610-5. CrossrefMedlineGoogle Scholar9. DindzansSchadeVan Thiel JRD. Medical problems before and after transplantation. Gastroenterol Clin North Am. 1988;17:19-31. CrossrefMedlineGoogle Scholar10. HeywardLanierMcMahon WAB. Early detection of primary hepatocellular carcinoma. Screening for primary hepatocellular carcinoma among persons infected with hepatitis B virus. JAMA. 1985;254:3052-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Medical College of Virginia, Richmond, Virginia; University of Washington Medical Center, Seattle, Washington; and The Johns Hopkins Hospital, Baltimore, Maryland. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Liver in Organ TransplantationThe Liver in Organ TransplantationLiverThe Liver in Organ TransplantationProphylaxsis against recurrance of hepatitis B virus after liver transplantation: a retrospective analysis spanning 20 yearsInfection in the Organ Transplant RecipientMalignant liver tumoursCancer Surveillance Following Orthotopic Liver TransplantationInfection in the bone marrow transplant recipient and role of the microbiology laboratory in clinical transplantationFailure of ganciclovir prophylaxis to prevent allograft reinfection following orthotopic liver transplantation for chronic hepatitis B infectionHEPATITIS B AND TRANSPLANTATIONInfection in the Organ Transplant RecipientPrimary care management of the liver transplant patientTreatment of small hepatocellular carcinoma in cirrhotic patients: A cohort study comparing surgical resection and percutaneous ethanol injectionCHANGING INDICATIONS FOR LIVER TRANSPLANTATIONLIVER TRANSPLANTATION FOR MALIGNANT DISEASELiver transplantation for primary hepatocellular carcinoma: tumor size and number determine outcomeLiver transplantation in chronic viral B and C hepatitisRecurrence of hepatitis B and delta hepatitis after orthotopic liver transplantation.Liver disease in the organ transplant recipient: Etiology, clinical impact, and clinical management 1 February 1991Volume 114, Issue 3Page: 212-213KeywordsChronic hepatitis BHepatitis AHepatocellular carcinomaInfectious diseasesInfectious hepatitisLiverLiver diseasesMean corpuscular volumeMedical risk factorsOrthotopic liver transplantation Issue Published: 1 February 1991 PDF DownloadLoading ...