tbuckley/cabot-search huggingface dataset:
Effect of Sedative Premedication on Patient Experience After General Anesthesia
Authors: Axel Maurice-Szamburski, Pascal Auquier, Véronique Viarre-Oreal, Philippe Cuvillon, Michel Carles, Jacques Ripart, Stéphane Honore, Thibaut Triglia, Anderson Loundou, Marc Leone, Nicolas Bruder
Journal: JAMA (2015)

<h3>Importance</h3> Sedative premedication is widely administered before surgery, but little clinical evidence supports its use. <h3>Objective</h3> To assess the efficacy of sedative premedication on perioperative patient experience. <h3>Design, Setting, and Participants</h3> A randomized clinical trial, the PremedX study, enrolled 1062 adult patients who were younger than 70 years and had been scheduled for various elective surgeries under general anesthesia at 5 French teaching hospitals (in Marseille, Montpellier, Nimes, and Nice) between January 2013 and June 2014. Neurosurgery, obstetrical, cardiac, and outpatient surgery were excluded. <h3>Interventions</h3> Patients were randomized to 3 groups of 354 participants each to receive 2.5 mg of lorazepam, no premedication, or placebo. <h3>Main Outcomes and Measures</h3> The primary outcome was perioperative patient experience assessed 24 hours after surgery with a validated questionnaire (Evaluation du Vécu de l'Anesthésie Generale; EVAN-G) describing 6 domains of satisfaction and a global index (score range, 0-100; high scores represent high satisfaction); secondary outcomes included time to extubation and early cognitive recovery. A subgroup analysis was planned a priori in patients with a high level of preoperative anxiety. <h3>Results</h3> Premedication with lorazepam did not improve the EVAN-G mean global index for overall level of patient satisfaction (72 [95% CI, 70-73]; n = 330) compared with no premedication (73 [95% CI, 71-74]; n = 319) or placebo (71 [95% CI, 70-73]; n = 322) (<i>P</i> = .38). Among patients with heightened preoperative anxiety, there were no significant differences found in the EVAN-G mean global index between the lorazepam group (68 [95% CI, 65-72]; n = 87) and the no premedication group (73 [95% CI, 69-77]; n = 57) or the placebo group (70 [95% CI, 67-72]; n = 87) (<i>P</i> = .18). Time to extubation was 17 minutes (95% CI, 14-20 minutes) in the lorazepam group, 12 minutes (95% CI, 11-13 minutes) for the no premedication group, and 13 minutes (95% CI, 12-14 minutes) for the placebo group (<i>P</i> &lt; .001) and the rate of early cognitive recovery was 51% (95% CI, 45%-56%), 71% (95% CI, 66%-76%), and 64% (95% CI, 59%-69%), respectively (<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> Among patients undergoing elective surgery under general anesthesia, sedative premedication with lorazepam compared with placebo or no premedication did not improve the self-reported patient experience the day after surgery, but was associated with modestly prolonged time to extubation and a lower rate of early cognitive recovery. The findings suggest a lack of benefit with routine use of lorazepam as sedative premedication in patients undergoing general anesthesia. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT01901003
Eosinophilic cellulitis as a presenting feature of chronic eosinophilic leukaemia, secondary to a deletion on chromosome 4q12 creating the <i>FIP1L1-PDGFRA</i> fusion gene
Authors: R.F. Davis, P. Dusanjh, A. Majid, A. Fletcher, A. Wardlaw, R. Siebert, M.J.S. Dyer, K.E. Harman
Journal: British Journal of Dermatology (2006)
METHOXY ISOBUTYL ISONITRILE (MIBI) IN THE EVALUATION OF PRIMARY CARCINOMA OF THE LUNG: COMPARISON OF PLANAR AND SPECT TECHNIQUES
Authors: A D Waxman, S Khan, P Julien, E Braum, G Ashok, L Ramanna, R D Katz, A Epstein, A Weber, R Wolfe
Journal: Clinical Nuclear Medicine (1993)

Waxman, A D; Khan, S; Julien, P; Braum, E; Ashok, G; Ramanna, L; Katz, R D; Epstein, A; Weber, A; Wolfe, R Author Information
Re: Enzo Palminteri, Elisa Berdondini, Fulvio Colombo and Edoardo Austoni. Small Intestinal Submucosa (SIS) Graft Urethroplasty: Short-term Results. Eur Urol 2007;51:1695–701
Authors: Fabio Campodonico, Alberto Michelazzi
Journal: European Urology (2007)
Cleavage of BCR–ABL transcripts at the T315I point mutation by DNAzyme promotes apoptotic cell death in imatinib-resistant BCR–ABL leukemic cells
Authors: J E Kim, S Yoon, B-R Choi, K P Kim, Y-H Cho, W Jung, D-W Kim, S Oh, D-E Kim
Journal: Leukemia (2013)
Treatment of cancer and allied diseases. Vol. VII: Tumors of the male genitalia and the urinary system.
Authors: J. U. Schlegel
Journal: JAMA (1963)

Thirty authors have contributed to this 20-chapter book of approximately 400 pages. The book is divided into two general sections, the first dealing with tumors of the male genitalia, and the second with tumors of the urinary system. Each section has an introduction regarding the over-all problems involved in etiology, diagnosis, and therapy. Almost every chapter gives an impressive review of the particular problem being dealt with, as well as excellent descriptions of surgical and radiological approaches to therapy. The large number of cases of prostatic carcinoma in men over 50, contrasted with the few cases seen early enough for radical surgical cure (the only known cure for this disease), are reemphasized by several of the authors. It is hoped that the general practitioner and the internist, who often are the first to see these patients, will restudy the statistics, so that early recognition and, consequently, cures, become possible. A
Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model
Authors: Christopher D. Hermann, David S. Wilson, Kelsey A. Lawrence, Xinghai Ning, Rene Olivares-Navarrete, Joseph K. Williams, Robert E. Guldberg, Niren Murthy, Zvi Schwartz, Barbara D. Boyan
Journal: Biomaterials (2014)
Agranulocytosis from Methaqualone?
Authors: FEREIDOUN AZIZI
Journal: Annals of Internal Medicine (1974)

Letters1 August 1974Agranulocytosis from Methaqualone?FEREIDOUN AZIZI, M.D.FEREIDOUN AZIZI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-2-268 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Methaqualone, a nonbarbiturate hypnotic, has been frequently used as an effective hypnotic (1, 2). The side effects of methaqualone are few, minor, and reversible (2, 3). The case described here is noteworthy because in many years of clinical use of methaqualone only one questionable case of bone marrow depression has been reported (4).A 68-year-old white man was admitted to Faulkner Hospital on 23 April after an exacerbation of his chronic bronchitis. He had had recurrent episodes of bronchitis for more than 10 years, which had been managed by intermittent use of tetracycline and promethazine (Phenergan®, Wyeth...References1. PARSONTHOMSON TT: Methaqualone as a hypnotic. Br Med J 1:171-173, 1961 CrossrefMedlineGoogle Scholar2. Methaqualone (Quaalude-300) and REM Sleep. Med Lett Drugs Ther 11:65-67, 1969 MedlineGoogle Scholar3. KESSELLMARRIOTTGRAVES APD: Methaqualone: efficicacy as a hypnotic and side effects. Med J Australia 1:531-534, 1971 CrossrefMedlineGoogle Scholar4. Tabulation of Reports Compiled by the Registry of Adverse Reactions of the Panel on Hematology, Council of Drugs, AMA. Chicago, American Medical Association, July 1964 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1974Volume 81, Issue 2Page: 268-269KeywordsBone marrowBronchitisChronic bronchitisTetracyclines Issue Published: 1 August 1974 PDF downloadLoading ...
MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy
Authors: Kerry J. Savage, Nathalie A. Johnson, Susana Ben-Neriah, Joseph M. Connors, Laurie H. Sehn, Pedro Farinha, Douglas E. Horsman, Randy D. Gascoyne
Journal: Blood (2009)
Quality of Life Assessment in the Randomized PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients With Atrial Fibrillation) Trial of Patients at Risk for Stroke With Nonvalvular Atrial Fibrillation
Authors: Oluseun Alli, Shepal Doshi, Saibal Kar, Vivek Reddy, Horst Sievert, Chris Mullin, Vijay Swarup, Brian Whisenant, David Holmes
Journal: Journal of the American College of Cardiology (2013)
87. Determinants of Toxicity Induced by In Vivo Expression of Short Hairpin RNA from AAV Vectors
Authors: Dirk Grimm, Konrad L. Streetz, Kusum Pandey, Theresa A. Storm, Mark A. Kay
Journal: Molecular Therapy (2005)

Double-stranded (ds) vectors based on Adeno-associated virus (AAV) are promising candidates for the in vivo delivery of short hairpin RNA (shRNA), as they give robust and stable gene expression, and lack any inherent toxicity. In efforts to engineer this vector towards clinical use, we evaluated a battery of dsAAVs, expressing shRNAs directed against transcripts from two different targets, Hepatitis B virus (HBV) or the human alpha-1-antitrypsin (hAAT) gene. We generated four individual vectors against each target, expressing shRNAs with stems ranging from 19 to 25 nucleotides in length. Each vector was pseudotyped with AAV-8 capsids for efficient liver transduction, and then injected into mice transgenic for the HBV or hAAT gene(s), respectively.
TREATMENT OF SUPERFICIAL NEW GROWTHS BY PURE RADIUM BROMID
Authors: FRANCIS H. WILLIAMS
Journal: JAMA (1913)

In comparing herpes zoster of the lower extremity with that of the trigeminus we find that the latter is much more frequent, its trophic manifestations are much more severe and, as we have seen, it is much more liable to be accompanied by paralysis of the muscles of the affected region.These différences are hcsl explained by considering herpes zoster a centripetal disease.In the two cases here reported as direct con¬ trasts, there was in the one involving the lower extremity a long-continued pre-eruptive neuralgia which we also regard as further evidence of the truth of our hypothesis.Besides these contrasts in the comportment of zoster of these two regions one of the most striking peculiarities of the disease, wherever it occurs, is its unilaterality, and comprehension of the mechanism of this character- islic is also facilitated by the same theory.Admitting, for example, that the virus may infect both conjunetivae simultaneously, yet in one it is almost sure to find a readier entrance into the nerve terminals than in the other, and the more fortunate infection will succeed in attaining the ganglion first, and therefore will cause the characteristic eruption before the other has time to develop.That the virus travels from the periphery toward the center seems to us to furnish the only reasonable explanation of the clinical facts enumerated above.The question of the primary lesion, the door of entrance of the virus, then arises.There are on the skin, and mucous membranes of the eye, nose, and mouth many opportunities for a virus to enter.The primary lesion may be insignificant and, from the very nature of the disease, may be long healed over by the time the trophic symptoms occur that we are used to considering as the entire phenomena of the disease.This disappear¬ ance of the primary lesion before the main phenomena of the disease appear is not limited to zoster.323 Geary Street.
Walter Reed: A Biography
Authors: Lester King
Journal: JAMA (1982)

The brilliant researches of Walter Reed proved that the mosquito<i>Aedes aegypti</i>transmitted yellow fever. This work, carried out with several collaborators, was a landmark in epidemiology and public health and certainly the greatest American medical contribution to that time. Yet, while the work is well known, the man remained a rather shadowy figure. Over many years, Dr Bean has collected material on Reed for this biography. He interviewed surviving members of the family and anyone who knew him or was in any way involved with his work. He collected letters, pored over archival material, ransacked newspaper files, and extended his researches to include friends and collaborators of Reed. In his epilogue, Bean says that he "tried to bring Walter Reed to life not simply as a 'medical hero' but as a man as well." In this he has succeeded. Reed emerges as a definitely three-dimensional figure, from youth to
Abstract 3858: Chronic myeloid leukemia in the aryl hydrocarbon receptor knockout mouse.
Authors: Ryan Butler, Margaret Warner, Jan-Åke Gustafsson
Journal: Cancer Research (2013)

Abstract The aryl hydrocarbon receptor (AhR) is a sensor of environmental toxins such as TCDD and its activation by these ligands can lead to immune system impairment, endocrine disruption and cancer. However, the normal physiological functions of AhR are still under investigation. We have previously reported the presence of large uric acid stones in the urinary bladder of AhR-/- mice and have traced this uric acid to rapid degradation of cells. In order to identify the cells that are dying, we examined the immune system of these mice. AhR -/- mice develop splenomegaly, increased number of megakaryocytes, increased circulating white blood cell count, enlarged lymph nodes, abnormalities in the bone marrow with many immature blast cells and severe myeloid cell infiltration into the liver and other tissues. The immune phenotype in these mice worsens as they age. The AhR -/- mouse phenotype, diagnosed as chronic myeloid leukemia, is similar to that of ERβ -/- mice but there is no loss of ERβ in AhR-/- mice. These studies suggest a novel mechanism for the development of chronic myeloid leukemia. Citation Format: Ryan Butler, Margaret Warner, Jan-Åke Gustafsson. Chronic myeloid leukemia in the aryl hydrocarbon receptor knockout mouse. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3858. doi:10.1158/1538-7445.AM2013-3858
TRITON HYPERLIPEMIA IN DOGS
Authors: Angelo Scanu, Pasquale Oriente
Journal: The Journal of Experimental Medicine (1961)

Triton WR-1339, a non-ionic detergent, added to canine serum or to ultracentrifugally separated lipoproteins, induced changes in the lipoproteins which were dependent upon concentration of detergent and class of lipoproteins. D 1.063 to 1.21 lipoprotein (alpha-LP) was especially sensitive to the action of triton. Addition of 2 mg. of triton to 1 mg. of alpha-LP (based on protein content), induced only slight changes in the electrophoretic and flotation characteristics of the lipoprotein. With a tenfold increase of the detergent (triton:alpha-LP, 20:1), the mixture, analyzed by starch gel and paper electrophoresis, yielded a tritonlipid complex which remained close to the origin, and a nearly lipid-free protein with electrophoretic mobility higher (starch gel) or lower (paper) than native alpha-LP. The splitting of the lipid and protein moieties of alpha-LP could not be clearly shown when the same mixture was analyzed by free boundary electrophoresis. Triton alone moved only slightly in an electrical field (paper, starch gel, Tiselius); it sedimented during ultracentrifugation at D 1.006 and D 1.063 and floated at D 1.21. D 1.006 to 1.063 lipoproteins (beta-LP), required larger amounts of triton to show changes. These were evident in 40 to 80:1 mixtures of triton and beta-LP. In starch gel and paper electrophoresis triton retained, in a position close to the origin, part of the lipids of beta-LP; the remaining beta-LP fraction, impoverished of lipids, had electrophoretic mobility similar to native beta-LP. The triton-lipid complex sedimented at D 1.063. After addition of triton to complexes [chylomicron-alpha-P-I(131)] or [lipomul-alpha-LP-1(131)], the electrophoretic and ultracentrifugal analyses of these mixtures revealed that the labeled protein was removed from the triglyceride component. Triton also prevented the occurrence of the interaction between lipomul and alpha-LP and the hydrolysis of both chylomicrons and lipomul-alpha-LP by lipoprotein lipase. It is postulated that, if the changes in lipoproteins and chylomicrons observed in vitro occur in vivo, they could account, at least in part, for the hyperlipemia which develops in animals following administration of triton.
Subtotal Esophagectomy with Cervical Esophagogastrostomy
Authors: David T. Monahan
Journal: New England Journal of Medicine (1950)

SINCE the publication of three separate reports1 2 3 of successful resection of the esophagus with anastomosis in the neck, it seems reasonable to conclude that this procedure has been established as a feasible maneuver. These patients were sixty-eight, fifty-nine and sixty-one years of age, and all stood the operation without untoward complications. One wonders if now is not the time to reevaluate the surgical approach to carcinoma of the esophagus and to perform this radical resection more frequently.Case ReportA 72-year-old widow entered the hospital on January 20, 1949, with a complaint of not being able to swallow anything but . . .
The Unethical in Medical Ethics
Authors: FRANZ J. INGELFINGER
Journal: Annals of Internal Medicine (1975)

An increasing societal recognition that the rights and dignity of the individual must be protected has led to an appropriate imposition of stricter ethical guidelines in medical research and practice. Occasionally, however, medical ethics is exploited. Examples are irresponsible accusations of unethical conduct, sensationalism, undue concern for prisoners as opposed to other experimental subjects, a bureaucratic proliferation of ethical regulations and review mechanisms, and a trivialization of ethical objectives. Such misuse of medical ethics compromises medical research, enhances public distrust of the physician, and devaluates medical ethics itself. The unethical in both medical practice and medical ethics can be contained by determined and greater effort to achieve understanding between physicians and ethicists.
Vascular endothelial growth factor stimulates skeletal muscle regeneration in Vivo
Authors: Nikola Arsic, Serena Zacchigna, Lorena Zentilin, Genaro Ramirez-Correa, Lucia Pattarini, Alessandro Salvi, Gianfranco Sinagra, Mauro Giacca
Journal: Molecular Therapy (2004)

Vascular endothelial growth factor (VEGF) is a major regulator of blood vessel formation during development and in the adult organism. Recent evidence indicates that this factor also plays an important role in sustaining the proliferation and differentiation of different cell types, including progenitor cells of different tissues, including bone marrow, bone, and the central nervous system. Here we show that the delivery of the 165-aa isoform of VEGF-A cDNA using an adeno-associated virus (AAV) vector exerts a powerful effect on skeletal muscle regeneration in vivo. Following ischemia-, glycerol-, or cardiotoxin-induced damage in mouse skeletal muscle, the delivery of AAV-VEGF markedly improved muscle fiber reconstitution with a dose-dependent effect. The expression of both VEGF receptor-1 (VEGFR-1) and VEGFR-2 was upregulated both in the satellite cells of the damaged muscles and during myotube formation in vitro; the VEGF effect was mediated by the VEGFR-2, since the transfer of PlGF, a VEGF family member interacting with the VEGFR-1, was ineffective. These results are consistent with the observation that VEGF promotes the growth of myogenic fibers and protects the myogenic cells from apoptosis in vitro and prompt a therapeutic use for VEGF gene transfer in a variety of muscular disorders.
Identification of an idiotypic peptide recognized by autoantibodies in human immunodeficiency virus-1-infected individuals.
Authors: Q L Wang, H T Wang, E Blalock, S Müller, H Köhler
Journal: Journal of Clinical Investigation (1995)

Antibodies against HIV-1 proteins in HIV-1-infected individuals share a cross-reactive idiotype defined by the monoclonal antiidiotypic antibody 1F7 (5). Using a computer algorithm based on the molecular recognition theory, regions of inverse hydropathy between the variable sequence of 1F7 and human monoclonal anti-HIV-1 antibodies were identified, which are assumed to be involved in idiotype-antiidiotype contacts. A peptide was designed from the proposed contact in the variable heavy chain framework 3-complementarity determining region 3 (FR3-CDR3) of human antibodies and was synthesized. This peptide is recognized by the antiidiotype 1F7 and inhibits the binding of 1F7 to human anti-HIV-1 antibodies which express the 1F7 idiotype. A survey of normal and HIV-1-infected sera revealed the presence of antibodies in infected sera which bind to the FR3-CDR3 peptide. The biological relevance of autoantibodies against a self idiotope associated with HIV-1 infection is discussed in the context of the regulation of the antibody response to HIV-1.
HIGHLY ABSORPTIVE CURCUMIN IMPROVES LEFT VENTRICULAR DIASTOLIC FUNCTION REGARDLESS OF BLOOD PRESSURE IN HYPERTENSIVE PATIENTS
Authors: Tatsuya Morimoto, Hiromichi Wada, Yoichi Sunagawa, Masatoshi Fujita, Hideaki Kakeya, Atsushi Imaizumi, Tadashi Hashimoto, Masaharu Akao, Yasufumi Katanasaka, Genta Osakada, Hirofumi Kambara, Hiroki Shiomi, Takeshi Kimura, Akira Shimatsu, Koji Hasegawa
Journal: Journal of the American College of Cardiology (2012)
980. In Vivo, High Throughput Analysis Expands the Known Anti-Ad Innate Immune Response Profile, and Implicates TLR Pathways in Ad Cellular Immune Response
Authors: Zachary Hartman, Anne Kiang, Andrea Amalfitano
Journal: Molecular Therapy (2006)

We exploited high titer adenoviral (Ad) vectors to more fully investigate the innate humoral and cellular responses to Ad gene transfer in vivo. As a result of this high throughput analysis, we have delineated a broader, and more potent innate humoral and cellular transcriptome response to Ad than has been previously reported. For example, gene array analysis revealed significant dysregulation in 20% of 12,000 RNA transcripts derived from the livers of Ad infected mice within hours of Ad injection. Bio-informatics based analysis of the data revealed a complex interplay between the innate and adaptive responses, akin to those observed when mice are challenged with LPS (i.e.: suppression of metabolism and mitochondrial genes) but with important differences. The Ad specific innate responses included upregulation of RNA regulatory mechanisms, purine nucleotide genes, and apoptosis-related pathways, and suppression of lysosome, endocytic, Wnt, and Calcium signaling pathways. Identification of novel, very rapid plasma cyto/chemokine elevations (IL-5, MCP-1, KC) were revealed by multiplexed, ELISA based methods. The combined approaches also implicated several TLR based gene networks as being Adresponsive. Subsequently, systemic Ad infections into MyD88-KO mice confirmed greatly diminished plasma cytokine and chemokine responses, as well as decreased liver expression of TLR, MAPK, cytokine receptor, mitochondrial, RNA regulation, cell cycle and growth, extracellular and adhesion, and immune response genes. In contrast, Ad treatments of TRIF-KO mice did not result in similar changes. Finally, continued Ad induction of several other innate functions, (innate immune genes, as well as elevations in several plasma cytokines/chemokines) even in Ad infected MyD88-KO mice confirms that this TLR pathway is not the only component of the Ad innate 'sensing mechanism' in vivo.