tbuckley/cabot-search huggingface dataset:
Anti-idiotypic antibodies prevent the serologic detection of antiribosomal P autoantibodies in healthy adults.
Authors: Z J Pan, C J Anderson, H A Stafford
Journal: Journal of Clinical Investigation (1998)

A subset of SLE patients has serologically detectable autoantibodies to the ribosomal P proteins (anti-P). We reported the discovery of covert anti-P antibodies and their masking IgG-inhibitory antibodies in the sera of healthy adults. The aim of this study was to determine if these IgG-inhibitory antibodies are anti-idiotypic antibodies (anti-Ids). IgG and IgG-depleted fractions of plasma from two healthy adults were assayed for inhibition of anti-P F(ab')2 binding to the ribosomal P proteins in immunoblot. Anti-P antibody activity was completely inhibited by plasma IgG, whereas there was no inhibition by IgG-depleted plasma. IgG-inhibitory antibodies recognized a cross-reactive epitope among anti-P from different SLE patients. Plasma IgG from one healthy adult was depleted of pepsin agglutinators and generic anti-F(ab')2 antibodies by adsorption with an affinity column prepared with normal IgG F(ab')2. Unretained IgG bound exclusively to anti-P F(ab')2 in ELISA. Using four affinity columns, we isolated IgG anti-Ids to anti-P antibodies from four healthy adults. These purified anti-Ids bound to anti-P F(ab')2 from a healthy adult and SLE patients. They did not bind to F(ab')2 fragments prepared from normal IgG or anti-dsDNA. Ribosomal antigens blocked this anti-Id-Id interaction. Purified anti-Ids inhibited the binding of anti-P F(ab')2 from patients to ribosomal P proteins. SLE patients without overt anti-P antibodies also possessed IgG anti-Ids to anti-P antibodies. We conclude that IgG-inhibitory antibodies are anti-Ids to anti-P antibodies, and are directed to public idiotopes on anti-P antibodies. These anti-Ids may be part of an Id network that regulates anti-P antibody expression, and perhaps pathogenicity.
Safety and efficacy of repetitive adenovirus–mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats
Authors: Joseph Zabner, Deanna M. Petersen, Aurita P. Puga, Scott M. Graham, Larry A. Couture, Lynn D. Keyes, Mike J. Lukason, Judith A. St. George, Richard J. Gregory, Alan E. Smith, Michael J. Welsh
Journal: Nature Genetics (1994)
Oral contraceptive use and fasting triglyceride, plasma cholesterol and HDL cholesterol.
Authors: C H Hennekens, D A Evans, W P Castelli, J O Taylor, B Rosner, E H Kass
Journal: Circulation (1979)

Fasting plasma triglyceride, plasma cholesterol and high-density lipoprotein (HDL) cholesterol levels were studied for 190 white women, ages 21--39 years, who were classified according to their oral contraceptive (OC) usage patterns at two community surveys, 3 years apart. The mean level of fasting triglyceride was higher among current OC users (95 mg/100 ml) than among nonusers (73 mg/100 ml) (p = 0.002). After adjustment for the possible confounding effects of age, weight, current cigarette smoking and fasting glucose level, current OC users still had a mean plasma triglyceride level 19 mg/100 ml higher than that of nonusers (p = 0.007). Current OC users also appeared to have somewhat higher levels of total cholesterol which were of borderline significance in crude and adjusted analyses. There was a nonsignificant inverse relationship of OC use with HDL cholesterol levels. Past use did not affect these results, indicating that the OC-induced lipid changes were reversible.
CEPHALIC TETANUS ACCOMPANIED WITH PARALYSIS OF THE FACIAL NERVE AND GENERALIZED TETANUS
Authors: William W. Tribby
Journal: JAMA (1941)

Only 12 cases of cephalic tetanus accompanied with paralysis of the facial nerve have appeared in the American literature, although well over 100 instances have been reported in foreign publications. In 1895, Willard<sup>1</sup>reviewed 74 cases of cephalic tetanus and reported the first case in America associated with paralysis of the facial nerve. In 1907 Eastman<sup>2</sup>wrote a short review of the cases reported by Willard,<sup>1</sup>Lange<sup>3</sup>and Lloyd<sup>4</sup>and added 3 previously unrecorded cases. He included reports on only those cases in which there was paralysis of one or more cranial nerves. The only other review of the American literature has been that of Brown,<sup>5</sup>who in 1912 found 93 cases reported in the world literature and added 1 of his own. Since that time 1 case has been reported by each of the following authors: Carson,<sup>6</sup>Carr,<sup>7</sup>Lewis,<sup>8</sup>Gray
Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies
Authors: Daniel W. Bowles, Jennifer R. Diamond, Elaine T. Lam, Colin D. Weekes, David P. Astling, Ryan T. Anderson, Stephen Leong, Lia Gore, Marileila Varella-Garcia, Brian W. Vogler, Stephen B. Keysar, Elizabeth Freas, Dara L. Aisner, Chen Ren, Aik-Chook Tan, Francois Wilhelm, Manoj Maniar, S. Gail Eckhardt, Wells A. Messersmith, Antonio Jimeno
Journal: Clinical Cancer Research (2014)

Abstract Purpose: To determine the pharmacokinetics (PK), maximum tolerated dose (MTD), safety, and antitumor activity of an oral formulation of rigosertib, a dual phosphoinositide 3-kinase (PI3K) and polo-like kinase 1 (Plk1) pathway inhibitor, in patients with advanced solid malignancies. Experimental Design: Patients with advanced solid malignancies received rigosertib twice daily continuously in 21-day cycles. Doses were escalated until intolerable grade ≥2 toxicities, at which point the previous dose level was expanded to define the MTD. All patients were assessed for safety, PK, and response. Urinary PK were performed at the MTD. Archival tumors were assessed for potential molecular biomarkers with multiplex mutation testing. A subset of squamous cell carcinomas (SCC) underwent exome sequencing. Results: Forty-eight patients received a median of 2 cycles of therapy at 5 dose levels. Rigosertib exposure increased with escalating doses. Dose-limiting toxicities were hematuria and dysuria. The most common grade ≥2 drug-related toxicities involved urothelial irritation. The MTD is 560 mg twice daily. Activity was seen in head and neck SCCs (1 complete response, 1 partial response) and stable disease for ≥12 weeks was observed in 8 additional patients. Tumors experiencing ≥partial response had PI3K pathway activation, inactivated p53, and unique variants in ROBO3 and FAT1, two genes interacting with the Wnt/β-catenin pathway. Conclusions: The recommended phase II dose of oral rigosertib is 560 mg twice daily given continuously. Urinary toxicity is the dose-limiting and most common toxicity. Alterations in PI3K, p53, and Wnt/β-catenin pathway signaling should be investigated as potential biomarkers of response in future trials. Clin Cancer Res; 20(6); 1656–65. ©2014 AACR.
Abnormalities in intestinal electrolyte transport in congenital chloridorrhoea
Authors: L. A. Turnberg
Journal: Gut (1971)

An investigation of small intestinal electrolyte transport was performed in a subject with congenital chloridorrhoea using a constant perfusion technique. The results indicate that the diarrhoea was not due to an abnormally high rate of secretion of fluid into the duodenum, and transport of electrolytes and glucose was normal in the jejunum. In contrast there was a marked abnormality of electrolyte transport in the ileum, chloride, sodium, and water entering the lumen and bicarbonate being absorbed in the absence of any concentration gradients for these ions. This is clearly different from the finding in normal subjects of sodium chloride and water absorption and bicarbonate secretion. It is suggested that the likely prime mechanism for these abnormalities is a chloride/bicarbonate exchange acting in the direction of chloride secretion, that is, in the opposite direction to the normal anion exchange. The hydrogen ion gradient set up by this exchange could have induced a secondary reversal of the normal sodium/hydrogen exchange so that hydrogen was absorbed and sodium secreted. From an analysis of the stool electrolyte concentrations and the rectal electrical potential difference it is suggested that in the colon chloride was secreted and bicarbonate absorbed against electrochemical gradients. Here too a reversed chloride/bicarbonate exchange is possibly responsible for the composition of the faecal electrolytes. As evidenced by the low faecal sodium concentration and the normal rectal potential difference, sodium transport is probably normal in the colon.
On the Treatment of Contracted Joints
Authors: H. Coote
Journal: BMJ (1858)

posing rather than an exciting cause.I have generally found that the cases of variola which were induced by inoculation have been milder than otlhers; and this may account for the facility with which this patient was cured.I conclude that this may be attributed to the absence of any marked constitutional debility.CASE iIi.Goolab, aged 25, became an out-patient May 17th, 1856, with variolous corneitis.The disease commenced twelve days after the separation of the crusts.The same remarks are here applicable with regard to the interval of time between the variolous outbreak and the invasion of the corneitis.CASE IV. 1amjaun Ali, aged 22, becane an out-patient June 6th, 1846, on account of corneitis and its results-dense opacities of the cornea.The inflammation had commenced fourteen days after the invasion of the fever.The opacities were in part removed.REMA1RKS.In this case, the interval of time was not as great, but the local affection seems to have been of a mild character; for I was only called upon to treat the consequences of the corneitis, and the case was in progress when the patient left off attending.These results were niot indelible.CASE V. Onrajee, aged 9, became an out-patient on June 9th, 1856, having chronic abscess of the cornea.Thiree months previously, an attack of variola came on, not from inoculation.The friends said that, at this time there was a small-pox pustule on the surface of the eye, and that the crust from this became separated at the same time as from the pustules on other parts of the body.Inflammation of the eye came on ten days after this separation.The treatment consisted of local depletion, purgatives, hydrargyrum cum creta, etc.June 23rd.The mouth had become slightly affected; but the patient was improving, and the matter of the abscess was becoming absorbed.July 2:3rd.The abscess was healed.The opacities of tlle cornea in its vicinity were thinning.The patient was in pro- cess of beinig cured.REMARKS.The corneitis does not seem here to have been part of the external manifestation of the variola, but to have occurred subsequently.The pustules, said to have been in coexistence with the small-pox in the body, most probably only affected the eyelids.CASE vi.Banepur, aged 10, was admitted as an out-patient on July 14th, 185(6.Variolous ophthalmia was present in both
Acute Dyspnea in a Young Woman Taking Birth Control Pills
Authors: Thomas E. Goffman
Journal: JAMA (1984)

History  A 26-year-old black woman was initially seen with an acute onset of shortness of breath, right-sided pleuritic pain in the chest, and a history of one week of pain without swelling of the right leg.  She denied any unusual medical history. A routine employment roentgenogram of the chest obtained two years earlier was normal. Her only medication was a mestranol-norethindrone combination product.  Physical examination revealed a well-developed, well-nourished woman in moderate respiratory distress. Her BP was 110/70 mm Hg; heart rate, 108 beats per minute; respirations, 28/min; and temperature, 37.8 °C. Pertinent physical findings included a left conjunctival nodule, right supraclavicular adenopathy, and bronchial breath sounds heard over the right upper-lung region. Her extremities were normal.  Findings from routine laboratory studies were unremarkable except for an ESR of 56 mm/hr. Arterial blood gas levels on room air were Po2, 77 mm Hg; Pco2, 30 mm Hg; and
EFFICACY OF SPOT STENTING WITH SIROLIMUS-ELUTING STENTS IN DIFFUSE LESIONS OF DIALYSIS PATIENTS
Authors: Tatsuya Ito, Masashi Kimura, Hiroshi Fujita, Mitsuyasu Terashima, Yoshihisa Kinoshita, Mariko Ehara, Nobuyoshi Tanaka, Kenya Nasu, Yasushi Asakura, Osamu Katoh, Takahiko Suzuki
Journal: Journal of the American College of Cardiology (2010)
Characterization of a dodecapeptide containing a dominant epitope of Par j 1 and Par o 1, the major allergens of <i>P. judaica</i> and <i>P. officinalis</i> pollen
Authors: T. Menna, G. Cassese, F. Di Modugno, A. Chersi, C. Buono, A. Ruffilli
Journal: Allergy (1999)

The pollen of Parietaria , a weed of the Urticaceae family, is a major cause of respiratory allergy in Europe, where the most common species are P. judaica and P. officinalis . Previously, we reported that a β‐galactosidase fusion protein (6a‐BG) expressing a 26‐bp cDNA fragment (6a cDNA) contained a dominant IgE‐binding epitope (6a epitope) of the major allergens Par o 1 and Par j 1. The present study aimed to define the amino‐acid sequence containing the 6a epitope. We analyzed the reactivity of anti‐Par o 1 antibodies affinity purified from allergic patient sera with: ) a panel of synthetic peptides deduced from the 6a nucleotide sequence using different reading frames ) glutathione S‐transferase (GST) fusion proteins containing selected peptides. The peptide NSARARADSCRI (p102) specifically bound anti‐Par o 1 antibodies affinity purified from allergic patient sera or from rabbit anti‐Par o 1 antiserum (ELISA). The related peptide NSARAGTSSCRI (p101) reacted to human but not to rabbit, anti‐Par o 1 antibodies. GST fusion proteins containing p101 (GST 3.5) or p102 (GST 3.2) extensively inhibited the binding between Par o 1 and IgE or IgG antibodies from an allergic patient serum pool according to a dose‐response curve. Percent inhibition of IgE antibodies binding obtained by absorbing a solution (50 μl) of affinity‐purified antibodies with 5 μg of GST 3.2 or with 1.2 mg of GST 3.5 was 69% and 66%, respectively. In conclusion, the results of the present study indicate that the amino‐acid sequences NSARARADSCRI (p102) and NSARAGTSSCRI (p101) contain the dominant epitope of Par o 1 and Par j 1 for human IgE and IgG antibodies indicated as 6a epitope. Moreover, the study shows that the epitope is conserved in recombinant molecules containing these peptides, irrespective of the fused polypeptide (β‐galactosidase or GST). The knowledge of the amino‐acid sequence of this dominant epitope is important in therapeutic approaches to the development of allergen‐derived haptens.
Vitamins in early pregnancy
Authors: D. Smithells
Journal: BMJ (1996)

Two vitamins have been making headlines in recent years because of their relation to congenital malformations: folic acid because it can prevent some, and vitamin A because it can cause them. In both cases the crucial issues are how much should be consumed in early pregnancy, and whether the vitamins should come from food, pills, or both.

There is now unimpeachable evidence that an adequate consumption of folic acid before conception and during the first two to three months of pregnancy significantly reduces the risk of neural tube defects.1 2 There is increasing evidence that folic acid may also reduce the risk of some other birth defects.3 The health departments of many countries have advised women who may become pregnant to increase their folic acid intake by 0.4 mg (400 μg) daily. This amount seems to be both safe and effective.

Unfortunately, although surveys show that the implementation of these policies is gradually increasing, only a minority of …
The expression of MHC class II (Ia) antigens on mouse keratinocytes following epicutaneous application of contact sensitizers and irritants
Authors: C.P. STRINGER, R. HICKS, P.A. BOTHAM
Journal: British Journal of Dermatology (1991)

The expression of MHC class II (Ia) antigens on mouse keratinocytes was studied following both the induction and elicitation of contact sensitivity and after primary irritant reactions IA+ and IE+ Keratinocytes were detected. using an indirect immunofluorescence assay on epidermal sheets, only after the induction and elicitation of contact sensitivity with the sensitizers oxazalone. picryl chloride and 2.4‐dinnitrochlorobenzene but not with formaldehyde. Ia+ keratinocytes were not detected after application of the non‐sensitizing irritants enoton oil, SDS and anthralin, or following attempted sensitization of nude mice. suggesting that the expression of la antigen on keratinocytes during contact sensitivity reactions is T‐cell mediated. Because Ia antigen expression on keratinocytes could be detected only several days after induction or elicitation of contact sensitivity. and contact sensitization could also be demonstrated to occur independently of aberrant Ia expression. Ia+ keratinocytes cannot be involved in the initiation of these reactions. However, they might be important in exerting an immunomodulatory influence during the later stages of the responses to certain sensitizers.
Post-Traumatic Stress Disorder in Child Survivors of Shipping Disasters: The Sinking of the &amp;lsquo;Jupiter&amp;rsquo;
Authors: William Yule
Journal: Psychotherapy and Psychosomatics (1992)

334 of over 400 children who survived the sinking of the cruise ship, Jupiter, in Athens harbour in October 1988 completed a battery of questionnaires 5-9 months later. Compared with age- and sex-matched controls, they show significantly higher scores on depression and anxiety. They also report more fears, particularly of stimuli related to the trauma. Overall, their scores on the Impact of Events Scale are as high as those reported by adults in other disasters. Follow-up studies a year after the accident reveal that nearly half the children meet the DSM-III-R criteria for PTSD. The usefulness of this screening battery is discussed. Some evidence for the effects of early intervention in schools is presented.
Aseptic Meningitis in Hong Kong
Authors: D. T. D. Hughes, J. F. Webb, W. K. Chang, R. J. C. Hart
Journal: BMJ (1963)

Small epidemics of aseptic meningitis are not uncommon among British Service personnel and their families in the Far East during the summer months.In 1960 and 1961 two such outbreaks occurred in the colony of Hong Kong, and this paper reports the clinical, epidemiological, and virological findings.A brief account of the first outbreak has already been published (Hart, 1961). Outbreak Clinical PictifeThe commonest presentation in this outbreak was with headache, fever, vomiting, and a stiff neck, while in many cases the illness also resembled influenza with coryza and generalized aches.Most patients presented signs of " meningism," though five never developed a stiff neck, while three more did so only after 24 hours or more in hospital.These features are shown in Table I,TABLE I.-Clinical Features of 31 Cases of Aseptic Meningitis In 1960 Abnormality Fever Headache Neck stiffness Vomiting Photophobia Coryza Injected fauces Aching limbs Drowsiness Palpable spleen Blurring of vision Congested fundal veins Pleuritic pain No. of No. of Cases Abnormality Cases 30 Abdominal pain ..3 27 Diarrhoea .323* Cough.3 18 Tremor.3 13 Febrile convulsion 2 11 Disorientation 2 9 Paraesthesiae in limbs 2 8 Pleural friction rub 7 Diplopla 1 4 Difficulty in micturition .. 4 Urinary incontinenoee 1 4 Bilateral flaccid pares of legs 1 4
Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations.
Authors: W Grossman, E Braunwald, T Mann, L P McLaurin, L H Green
Journal: Circulation (1977)

End-systolic pressure (PES), volume (VES), wall tension (TES) and circumference (CES) of the human left ventricle were studied at cardiac catheterization in 24 subjects with varying degrees of left ventricular dysfunction. Acute alterations in systolic load consistently resulted in changes in VES and CES, with a smaller volume and circumference characterizing the lower systolic load in each subject. End systolic pressure-volume lines were constructed by plotting PES against VES at the higher and lower systolic load in each subject. The slope of the resultant lines was considerably steeper for normal than for poorly contractile left ventricles. Vo, the volume axis intercept of the line (i.e., the theoretical VES at PES = O) was significantly smaller for normal than for poorly contractile ventricles. Similar findings were noted for Co, the theoretic end-systolic circumference at zero end-systolic ventricular wall tension. Post-extrasystolic potentiation resulted in decreased VES and CES with no change in PES and only a slight fall in TES. In conclusion, end-systolic pressure-volume and tension-circumference relations reflect the contractile state of left ventricular myocardium. Quantitation of these relationships may provide a useful new approach to the assessment of myocardial function in man.
UPSTREAM VERSUS DEFERRED ADMINISTRATION OF SMALL-MOLECULE GLYCOPROTEIN IIB/IIIA INHIBITORS IN PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: INSIGHTS FROM RANDOMIZED CLINICAL TRIALS
Authors: Lili Dong, Feng Zhang, Xianhong Shu
Journal: Journal of the American College of Cardiology (2010)
Device based left ventricular shape change immediately improves ventricular function in a canine heart failure model
Authors: R. Starling, P.M. McCarthy, K. Fukamachi, M. Takagaki, Y. Ochiai, T. Tabata, L. Cordon, T. Shiota, J.B. Young, C.J. Schweich
Journal: European Journal of Heart Failure (2000)
Progressive nodular histiocytosis accompanied by systemic disorders
Authors: A. Gonzalez Ruíz, A.I. Bernal Ruíz, H. Aragoneses Fraile, I. Peral Martinez, M. García Muñoz
Journal: British Journal of Dermatology (2000)

Progressive nodular histiocytosis is a proliferative process of histiocytes, the main element of which is the dermal dendrocyte. It is considered to form part of a group of histiocytic disorders related to juvenile xanthogranuloma, which also includes xanthoma disseminatum, benign cephalic histiocytosis, spindle cell xanthogranuloma and generalized eruptive histiocytosis; disorders which perhaps represent the spectrum of one single entity. We present the case of a 57-year-old man who, for 26 years, had had a progressively deforming process of cutaneous lesions, with systemic involvement, including chronic myeloid leukaemia, hepatosplenomegaly, hypothyroidism, hyperuricaemia and hypocholesterolaemia. We have not been able to establish precisely the relationship between these features.
Cancer of the Prostate
Authors: Michael E. Stuart
Journal: JAMA (1992)

<h3>To the Editor.</h3> —We would like to comment on the Editorial by Oesterling<sup>1</sup>regarding PSA testing. Oesterling, in recommending PSA testing and surgery, appears to assume that all prostate cancers discovered by PSA testing will act in a malignant fashion and require surgery. This assumption needs to be addressed. First, autopsy studies have demonstrated that many or most cases of prostatic carcinoma are latent or indolent. The incidence of prostate cancer increases from 30% in the fifth decade to close to 100% in men over the age of 90 years. In contrast to this increasing incidence, the cumulative lifetime risk for death is only 2.5%,<sup>2</sup>and the average 5-year age-specific prostate cancer mortality in men aged 50 through 74 years never exceeds 0.14%.<sup>3</sup>There are currently no data to show that PSA testing differentiates between indolent and aggressive cancers. Screening for cancer of the prostate will likely