tbuckley/cabot-search huggingface dataset:
Hyperostosis of the spine in an adult population. Its relation to hyperglycaemia and obesity.
Authors: H Julkunen, O P Heinonen, K Pyorala
Journal: Annals of the Rheumatic Diseases (1971)

<h3>Objective</h3> To examine the SARS-CoV-2 infection rate in a cohort of 6500 professional athletes and staff during the 2020 football (soccer) season in São Paulo, Brazil. <h3>Methods</h3> This retrospective cohort study included 4269 players (87% male, age: 21.7±4.2 years) and 2231 staff (87% male, age: 42.6±11.9 years) from 122 teams (women: n=16) involved in eight leagues (women: n=2), which took place in São Paulo, Brazil. Between 4 July 2020 and 21 December 2020, swab samples were collected weekly (n=29 507) and tested for SARS-Cov-2 via reverse transcription-PCR by an accredited laboratory commissioned by the São Paulo Football Federation. We contacted the medical staff of each team with positive cases to collect information on disease severity. <h3>Results</h3> Among 662 PCR-confirmed cases, 501 were athletes and 161 were staff. The new infection rate was 11.7% and 7.2% for athletes and staff, respectively. Athletes were more susceptible to infection than staff (OR: 1.71, 95% CI: 1.42, 2.06, p&lt;0.001), although with lower chance for moderate to severe disease (OR: 0.06, 95% CI: 0.01, 0.54, p=0.012). Six teams had ≥20 individuals testing positive for SARS-CoV-2, whereas 19 teams had ≥10 confirmed cases. Twenty-five mass outbreaks were identified (≥5 infections within a team in a 2-week period). The prevalence of SARS-CoV-2 infections was similar in athletes and staff as the general population in São Paulo. <h3>Conclusion</h3> Despite weekly testing and other preventive measures, we found a high SARS-CoV-2 infection rate in athletes and staff after resuming football, which coincides with the high prevalence of infection in the community during the same period. These data may assist policy-makers and sports federations for determining if and when it is safe to resume competitions.
Offspring of Patients With Diabetes Exhibit a Clustering of Psychosocial Distress and Inflammatory and Metabolic Risk Factors
Authors: Jessica E. Shill, Mark N. Feinglos, Edward C. Suarez
Journal: Diabetes Care (2008)

Family history of type 2 diabetes is associated with vascular, inflammatory, and metabolic abnormalities (1). Although psychological distress has been similarly associated with these same biological abnormalities (2) and found to significantly predict 20-year incidence of coronary heart disease (3), no study has examined the relationship of family history of diabetes with markers of psychological distress. We examined the relationship between parental history of diabetes and metabolic and inflammatory biomarkers and indicators of psychosocial distress (i.e., depression, hostility, anger, and social support) measured by validated self-report scales. Subjects were 68 nonsmoking and apparently healthy nondiabetic adults (aged 33 ± 10 years; 56% female; 40% minorities, 26% of whom were African American) …
Enhanced antiplasmin activity in acute renal failure.
Authors: A Kanfer, A Vandewalle, M Beaufils, F Delarue, J D Sraer
Journal: BMJ (1975)

Plasmatic slow plasmin-inhibitor activity was assessed in 20 patients with acute renal failure and 12 controls with the fibrin plate method. The area of fibrinolysis was 250-5 +/- 5 mm2 in the patients and 289 +/- 6mm2 in the controls (P less than 0.001) and was negatively correlated with antiplasmin activity. Thirteen patients had areas of lysis equal to or inferior to the minimal lysis observed in the controls. No correlation was found between antiplasmin activity and serum fibrin-fibrinogen related antigen titres, the presence or absence of disseminated intravascular coagulation, or the causative disease.
THE REAL POSTION OF WILLAN AND BATEMAN'S TEACHING IN REGARD TO ECZEMA.
Authors: H. G. ADAMSON
Journal: British Journal of Dermatology (1933)

Journal Article THE REAL POSTION OF WILLAN AND BATEMAN'S TEACHING IN REGARD TO ECZEMA. Get access H. G. ADAMSON H. G. ADAMSON Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 12, 1 December 1933, Pages 493–497, https://doi.org/10.1111/j.1365-2133.1933.tb10130.x Published: 01 December 1933
Lifestyle Changes, Low-Dose Diuretics Should Be First Choice for Treating Hypertension in the Elderly
Authors: Claude Lenfant
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RUPTURE OF HYDATID TUMOR INTO THE PERITONEAL CAVITY, WITH RECOVERY.
Authors: N. C. Markham
Journal: JAMA (1883)

August 25, 1883. This case is reported for its rarity, in fact non-precedence, as far as we are able to ascertain. E. C., age 43, American, county sheriff. Some three years ago this gentleman called upon me for relief from an alleged scrotal hernia of the right side. Examination disclosed the disease as an indurated testicle. He had pain in the right lumbar region, which was attributed to the supposed hernia; this pain had at intervals annoyed him for several years, during which time its true source had escaped detection. Previous to his call upon me he had noticed an enlargement in his right side, which had slowly increased in size, and which, in connection with resulting symptoms, was the occasion of his seeking aid. He was slightly jaundiced, with loss of appetite and tenderness of the hepatic region, the latter much aggravated by turning while in a recumbent position.
Arterial Chemoembolization With Microencapsulated Anticancer Drug
Authors: Tetsuro Kato
Journal: JAMA (1981)

Selective intra-arterial infusion of ethylcellulose microcapsules containing mitomycin exerts its therapeutic effects through infarction and sustained drug action—ie, chemoembolization. Sixty primary or secondary carcinomas in the kidney, liver, urinary bladder, prostate, cervix, vagina, sigmoid colon, Douglas' pouch, and bone were treated with single or repeated chemoembolizations using microcapsules delivered through percutaneous catheterization as a preoperative or palliative measure. Substantial tumor reduction of greater than 30% in measurable maximum diameter was found in 65% of the tumors; pain relief occurred in 80% and hemostasis in 100%. Preoperative chemoembolization remarkably facilitated radical surgery in 18 (82%) of 22 patients. The summed response rate was 77%. Systemic toxic effects were mild, and all patients tolerated the treatment. Though the follow-up periods are less than two years, 37 patients are alive with or without tumor. (<i>JAMA</i>1981;245:1123-1127)
Glycerolipid Metabolism and Signaling in Health and Disease
Authors: Marc Prentki, S. R. Murthy Madiraju
Journal: Endocrine Reviews (2008)

Abstract Maintenance of body temperature is achieved partly by modulating lipolysis by a network of complex regulatory mechanisms. Lipolysis is an integral part of the glycerolipid/free fatty acid (GL/FFA) cycle, which is the focus of this review, and we discuss the significance of this pathway in the regulation of many physiological processes besides thermogenesis. GL/FFA cycle is referred to as a “futile” cycle because it involves continuous formation and hydrolysis of GL with the release of heat, at the expense of ATP. However, we present evidence underscoring the “vital” cellular signaling roles of the GL/FFA cycle for many biological processes. Probably because of its importance in many cellular functions, GL/FFA cycling is under stringent control and is organized as several composite short substrate/product cycles where forward and backward reactions are catalyzed by separate enzymes. We believe that the renaissance of the GL/FFA cycle is timely, considering the emerging view that many of the neutral lipids are in fact key signaling molecules whose production is closely linked to GL/FFA cycling processes. The evidence supporting the view that alterations in GL/FFA cycling are involved in the pathogenesis of “fatal” conditions such as obesity, type 2 diabetes, and cancer is discussed. We also review the different enzymatic and transport steps that encompass the GL/FFA cycle leading to the generation of several metabolic signals possibly implicated in the regulation of biological processes ranging from energy homeostasis, insulin secretion and appetite control to aging and longevity. Finally, we present a perspective of the possible therapeutic implications of targeting this cycling.
US Justice Department appeals against the rulings that banning partial birth abortion is unconstitutional
Authors: Janice Hopkins Tanne
Journal: BMJ (2004)

The US Justice Department filed appeals against all three court rulings that found the federal law banning “partial birth abortion” unconstitutional. The US Conference of Catholic Bishops commended the Justice Department and said, “There is no place in a civilised society for this cruel and inhumane practice.”

The federal law banning partial birth abortion was passed by Congress in 2003 and signed by President George Bush, who called it an “abhorrent” practice ( BMJ 2003;327:1009). The law does not describe the technique in medical terms. Doctors say it may apply to intact dilatation and evacuation and to most techniques used in second trimester abortions.

The law was immediately challenged in Nebraska, California, and New York. Courts in those states held it …
Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells.
Authors: Silvia Ottaviani, Sean Delaney, Hetal Patel, Manikandan Periyasamy, Alexander Bondke, Brian Slafer, Richard Starkey, Sebastian H.B. Kroll, Matthew J. Fuchter, Anthony G.M. Barrett, R. Charles Coombes, Simak Ali
Journal: Cancer Research (2013)

Abstract Cyclin-dependent kinases (CDKs) form complexes with partner cyclins to regulate cell cycle progression and transcription. CDK1, CDK2, CDK4 and CDK6 all regulate cell cycle progression and CDK8 and CDK9 are regulators of transcription. CDK7 is a unique member of this family because it can regulate the cell cycle CDKs as part of the CDK-activating kinase (CAK) and also transcription in conjunction with the TFIIH transcription factor by phosphorylating the COOH-terminal domain of RNA polymerase II (Pol II CTD). A hallmark of cancer is deregulated cell cycle progression and many cancers have abnormal CDK activity which makes CDKs a good target for cancer therapy. Here we show BS-194, a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7 and CDK9 (IC50 = 3, 30, 30, 250 and 90nmol/L, respectively). In vitro cell based assays have shown that BS-194 inhibits the phosphorylation of CDK substrates, Rb and RNA Poll II, down regulation of cyclins A, E and D1 and cell cycle arrest in the S and G2/M phases. BS-194 also has potent anti-proliferative activity in 60 cancer cell lines tested (mean GI50 = 28nmol/L). BS-194 is orally bioavailable and shows potent in vivo tumour growth inhibition of xenograft models of MCF7 and HCT116 cells. We have used BS-194 as a potent inhibitor of CDK activity in HCT116 cells and performed gene microarray analysis to determine novel pathways and identify novel biomarkers associated with CDK inhibition. In summary, the gene microarray has identified genes differentially expressed in response to BS-194 treatment that are primarily involved in cell cycle, apoptosis and transcription pathways. Citation Format: Silvia Ottaviani, Sean Delaney, Hetal Patel, Manikandan Periyasamy, Alexander Bondke, Brian Slafer, Richard Starkey, Sebastian H.B. Kroll, Matthew J. Fuchter, Anthony G.M. Barrett, R. Charles Coombes, Simak Ali. Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 700. doi:10.1158/1538-7445.AM2013-700
Delayed-Onset Heparin-Induced Thrombocytopenia
Authors: Robert Kane
Journal: Annals of Internal Medicine (2003)

Letters4 November 2003Delayed-Onset Heparin-Induced ThrombocytopeniaRobert Kane, MDRobert Kane, MDFrom Florida Cancer Specialists; Venice, FL 34285.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-9-200311040-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Rice and colleagues (1) highlighted an important distinction in patients who experience a thromboembolic event in the days or weeks after a medical intervention: Is this event related to a disease process or to treatment with heparin? How often does this occur as a delayed event in patients after a course of heparin? Is this a possible cause of warfarin resistance? Does a decline in platelet count of a certain amount or at a certain time predict heparin-induced thromboembolism? If heparin-type therapy is to be restarted after a previous medical intervention that included heparin, what additional monitoring ...Reference1. Rice L, Attisha WK, Drexler A, Francis JL. Delayed-onset heparin-induced thrombocytopenia. Ann Intern Med. 2002;136:210-5. [PMID: 11827497] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Robert Kane, MDAffiliations: From Florida Cancer Specialists; Venice, FL 34285. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDelayed-Onset Heparin-Induced Thrombocytopenia Lawrence Rice , Walid K. Attisha , Alane Drexler , and John L. Francis Delayed-Onset Heparin-Induced Thrombocytopenia Lawrence Rice , Walid K. Attisha , and John L. Francis Delayed-Onset Heparin-Induced Thrombocytopenia John R. De Palma Metrics Cited byCurrent awareness: Pharmacoepidemiology and drug safety 4 November 2003Volume 139, Issue 9Page: 790KeywordsDrug therapyHeparinHeparin-induced thrombocytopeniaMilkPlateletsSpecificityThromboembolism ePublished: 4 November 2003 Issue Published: 4 November 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Pathogenesis of the Ovarian Hyperstimulation Syndrome
Authors: Ursula Brigitte Kaiser
Journal: New England Journal of Medicine (2003)

The ovarian hyperstimulation syndrome is an iatrogenic complication of ovulation-induction therapy. In its most severe form, this syndrome involves massive ovarian enlargement and the formation of multiple ovarian cysts, fluid shifts resulting in extravascular fluid accumulation and intravascular volume depletion, renal failure, hypovolemic shock, and in some cases, death. The severe form is rare, with a reported incidence of 0.5 to 5 percent among patients undergoing ovulation-induction therapy.Ovulation-induction therapy is generally initiated with gonadotropins to stimulate follicle development and growth. The intensity of the ovarian hyperstimulation syndrome is related to the degree of ovarian follicular response. Estrogens, produced by . . .
Intestinal perfusion studies in tropical sprue. 2. Movement of water and electrolytes.
Authors: M D Hellier, P Bhat, J Albert, S J Baker
Journal: Gut (1977)

Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorption from the free amino acid or dipeptide solutions showed no significant difference between the groups and was similar to absorption from normal saline. These results differ from data obtained in normal English subjects where at these concentrations significant stimulation of sodium and water absorption was seen. In a proportion of subjects in both groups net secretion was observed. However, no correlation was seen between mucosal histology or luminal bacteriology and sodium or water movement. These findings in patients with chronic tropical sprue are similar to findings in normal Indians and suggest that jejunal handling of sodium and water is abnormal when compared with normal English subjects, but that the mucosa is not in a secretory phase as seen in certain other diarrhoeal states or in the acute early phase of sprue.
Self recognition by T cells. I. Bystander killing of target cells bearing syngeneic MHC antigens.
Authors: R C Duke
Journal: The Journal of Experimental Medicine (1989)

Activated CTL can kill any cell to which they bind or by which they are bound. This observation has been used to determine whether alloreactive CTL can recognize cells bearing self-MHC. When activated by their specific targets, 19 CTL clones of 4 different specificities and origins killed bystander targets bearing syngeneic but not third-party MHC antigens. Using target cells derived from MHC-recombinant animals, syngeneic bystander killing was shown to be restricted to a single self MHC-encoded molecule. These results provide the first clear demonstration that T cells, or more precisely CTL, are capable of self recognition in the absence of their specific antigen. Our findings support the model that T cell repertoire selection occurs as a result of positive selection during maturation in the thymus of precursor cells whose antigen receptors have low but real affinity for self-MHC.
Influence of Complications on Therapeutic Goal in Rheumatoid Arthritis.
Authors: Irving Karten
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Influence of Complications on Therapeutic Goal in Rheumatoid Arthritis.Irving Karten, M.D., F.A.C.P., Currier McEwen, M.D., (Master)Irving Karten, M.D., F.A.C.P.Search for more papers by this author, Currier McEwen, M.D., (Master)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-811_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRehabilitation of the patient with rheumatoid arthritis is exceptionally difficult because of the severe mechanical limitation produced by joint deformities and the uncertain course of the disease activity. Furthermore, the disease or its treatment make the rheumatoid patient susceptible to infections and other complications that may threaten his life or delay his long-term rehabilitation.During a 5-year period, of 101 patients with rheumatoid arthritis admitted for rehabilitation and followed from 1 to 4 years, 26 died and 19 others had major complications. Death was due to Gram-negative sepsis in four; pneumonia, four; bacteroides arthritis, one; gastrointestinal hemorrhage, two; diffuse vasculitis,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 811-812KeywordsArthritisBacteroidesGastrointestinal hemorrhageInfectious diseasesPneumoniaRheumatoid arthritisSepsisVasculitis Issue Published: 1 May 1970 PDF DownloadLoading ...
DIAGNOSTIC PERFORMANCE OF IFR FOR EVALUATION OF INTERMEDIATE LEFT MAIN CORONARY ARTERY STENOSES
Authors: Ciro Indolfi, Annalisa Mongiardo, Carmen Spaccarotella, Daniele Torella, Gianluca Caiazzo, Giovanni De Velli, Micaela Conte, Alberto Polimeni, Sabato Sorrentino, Marco Contarini, Daniel Todaro, Salvatore De Rosa
Journal: Journal of the American College of Cardiology (2015)
Polymorphonuclear cell count response and duration of antibiotic therapy in spontaneous bacterial peritonitis
Authors: Tse-Ling Fong, Evangelos A. Akriviadis, Bruce A. Runyon, Telfer B. Reynolds
Journal: Hepatology (1989)

The purposes of this study were (a) to measure serially ascitic fluid polymorphonuclear cell response in treated spontaneous bacterial peritonitis and (b) to determine whether an ascitic fluid polymorphonuclear cell count of less than 250 per mm 3 on serial paracenteses was a satisfactory endpoint for antibiotic therapy. Thirty of 33 patients showed an exponential fall in ascitic fluid polymorphonuclear cell count after 48 hr of antibiotic therapy; the magnitude of decrease correlated with survival (p&lt;0.01). Among the patients whose antibiotic therapy was discontinued when the ascitic fluid polymorphonuclear cell count reached 250 per mm 3 or less, the duration of therapy was considerably shorter than for the patients who received “conventional” therapy (p&lt;0.01). Recurrence of spontaneous bacterial peritonitis was similar in the two groups. Mortality correlated with the severity of underlying liver disease but not with duration of antibiotic therapy.
The association of postural changes in systolic blood pressure and mortality in persons with hypertension: the Hypertension Detection and Follow-up Program experience.
Authors: B R Davis, H G Langford, M D Blaufox, J D Curb, B F Polk, N B Shulman
Journal: Circulation (1987)

Participants in the Hypertension Detection and Follow-up Program (HDFP) were classified on the basis of baseline standing minus sitting systolic blood pressure into four groups (less than or equal to -20 [group 1], -19 to 0 [group 2], 1 to 20 [group 3], and greater than 20 mm Hg [group 4]) to study 5 year mortality. Group 1, 3.3% of the total, contained those participants who had postural hypotension. The 5 year total and age-adjusted mortality rates for these groups were significantly different (p less than .04), with group 1 having the highest rates. To account for the possible confounding effects of certain baseline risk factors--age, sex, race, prior antihypertensive treatment, randomization group, diabetes, end-organ damage, sitting diastolic and systolic blood pressures, pulse, hematocrit, smoking status, and relative weight (percent of ideal weight)--in assessing group differences in mortality rates, a multiple logistic model was used. Relative weight proved to be a confounding factor for the association of drop in postural systolic blood pressure with mortality. However, there is an interaction between history of diabetes and postural change in systolic blood pressure. Thus, postural hypotension may indicate a poor prognosis in diabetic hypertensive patients.
Severe Skin Lesions Cause Patients With Inflammatory Bowel Disease to Discontinue Anti–Tumor Necrosis Factor Therapy
Authors: Jean–François Rahier, Sébastien Buche, Laurent Peyrin–Biroulet, Yoram Bouhnik, Bernard Duclos, Edouard Louis, Pavol Papay, Matthieu Allez, Jacques Cosnes, Antoine Cortot, David Laharie, Jean–Marie Reimund, Marc Lémann, Emmanuel Delaporte, Jean–Frédéric Colombel
Journal: Clinical Gastroenterology and Hepatology (2010)