tbuckley/cabot-search huggingface dataset:
Moving forward: to surgery by taxi, or a home visit?
Authors: S. J Parkes
Journal: BMJ (1996)

Three years ago I started to offer patients the option of a free trip to and from the surgery by taxi as an alternative to a home visit. If necessary they can be seen on arrival without waiting. This service has not been abused and the total number of home visits and patients' taxi trips is less than half my previous home visits. The balance is made up by family and friends bringing patients to the surgery.

In my inner city practice of 2107 patients I make an average of four visits a week and provide a similar number of taxi trips. I never refuse a visit, but always make it plain if I think that the patient is making an unnecessary fuss. With most acute illnesses, advice about taking the maximum dose of paracetamol and leading a relatively quiet life but not being bedbound or housebound is appropriate. It is what I do for myself and my family. The taxi is also …
Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia
Authors: Eszter S. Hars, Yi Lisa Lyu, Chao-Po Lin, Leroy F. Liu
Journal: Cancer Research (2006)

Abstract Etoposide-induced treatment-related acute myelogenous leukemia (t-AML) is characterized by rearrangements of the mixed lineage leukemia (MLL) gene with one of its &amp;gt;50 partner genes, most probably as a consequence of etoposide-induced DNA double-strand breaks (DSBs). Recent studies have shown that etoposide-induced DSBs occur predominantly within the breakpoint cluster region (bcr) of the MLL gene. However, bcr-specific DSBs induced by etoposide are not topoisomerase II–linked but the result of apoptotic nuclease–mediated DNA cleavage. Here, we test the involvement of caspase-activated DNase (CAD) and other apoptotic components in etoposide-induced gene rearrangements using two methods. First, we measured the effect of etoposide on the integration frequency of a transfected plasmid. Etoposide strongly stimulated plasmid integration in CAD cDNA–complemented mouse embryonic fibroblasts (MEFs) but not in CAD knockout (KO) MEFs. Consistently, down-regulation of ICAD (inhibitor of CAD, also required for proper folding of CAD) in an HT29-derived cell line, which leads to decreased CAD activity, significantly reduced etoposide-induced plasmid integration. Second, we used long-template inverse PCR to focus on gene rearrangements at the MLL locus. Etoposide stimulated MLL fusion product formation in CAD cDNA–complemented MEFs but not in CAD KO MEFs. Together, these results suggest that CAD and other apoptotic components may play an important role in etoposide-induced t-AML. (Cancer Res 2006; 66(18): 8975-9)
Treatment of advanced malignant eccrine poroma with locoregional chemotherapy
Authors: E. de Bree, E. Volalakis, D. Tsetis, Y. Varthalitis, J. Panagiotidis, J. Romanos, D.D. Tsiftsis
Journal: British Journal of Dermatology (2005)

Malignant eccrine poroma is a rare disease with approximately 200 cases reported in the literature. Regional cutaneous and systemic metastases are rarely observed and their management has been generally unsuccessful. We report on a case in which topical 5-fluorouracil application and intra-arterial chemotherapy with docetaxel resulted in a histologically confirmed complete response of multiple regional skin metastases for more than 2 years. Despite intravenous administration of docetaxel, slow progression of systemic disease was observed.
Effect of Hyperventilation on Precordial T Waves of Children and Adolescents
Authors: J. H. THOMSEN, R. H. WASSERBURGER
Journal: Circulation (1967)

Following the taking of 12-lead routine electrocardiograms, three precordial leads were recorded before, during, and after 10 to 15 seconds of voluntary hyperventilation in 296 students, ranging in age from 8 to 17 years. Fifteen per cent of the total group, comprising 212 Caucasians and 84 Negroes, inverted one or more previously upright precordial T waves following hyperventilation. The incidence of T-wave inversion in children 12 years of age and under was nearly four times greater in Caucasians than in Negroes. There was no significant difference when the older Negro and Caucasian students were similarly compared. Sinus tachycardia, T-wave flattening, and "tucking," short of frank inversion, as well as junctional depression of the ST segment, were commonly seen following hyperventilation. The similarity of the hyperventilation-induced T-wave inversion in children to those previously documented in adults is noted, and the clinical implication of this study requires continued cognizance of the occurrence of "nonpathological" T-wave inversion in adults, so as to avoid iatrogenic heart disease.
The unique acyl chain specificity of biliary phosphatidylcholines in mice is independent of their biosynthetic origin in the liver
Authors: Luis B. Agellon, Christopher J. Walkey, Dennis E. Vance, Folkert Kuipers, Henkjan J. Verkade
Journal: Hepatology (1999)

The liver synthesizes phosphatidylcholine (PC) de novo from choline via the CDP-choline pathway, and from phosphatidylethanolamine (PE) via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway. Significant amounts of PC, which are highly specific in their acyl chain composition, are secreted into bile by the liver. To determine whether either of the 2 PC biosynthetic routes is sufficient to provide physiological PC concentrations in bile, or is responsible for the unique acyl chain composition of bile PC, we analyzed gallbladder bile composition in mice that synthesized PC either via the PEMT pathway (induced by feeding a choline-deficient diet) or the CDP-choline pathway (based on genetic PEMT-deficiency). The PC concentration in gallbladder bile of mice that synthesize PC mainly via the CDP-choline pathway was comparable with control mice that synthesize PC via both pathways, whereas it was reduced by approximately 40% in mice that synthesize PC via the PEMT pathway. The acyl chain composition of bile PC was similar irrespective of the active PC biosynthetic pathway in the liver. These data demonstrate that the CDP-choline pathway alone, but not the PEMT pathway alone, can account for physiological concentrations of PC in gallbladder bile. Moreover, the specificity of biliary PC fatty acyl composition is determined independently from the synthetic origin of PC.
Total leucoderma: a rare manifestation of cutaneous chronic graft-versus-host disease
Authors: A. NAGLER, M.A. GOLDENHERSH, F. LEVI-SCHAFFER, J.-C. BYSTRYN, S.N. KLAUS
Journal: British Journal of Dermatology (1996)

We describe a 14-year-old boy who developed total leucoderma during the course of chronic graft-versus-host disease, which developed after allogeneic bone marrow transplantation. Skin biopsy and dihydroxy-phenylalanine staining revealed a total absence of melanocytes from the epidermis. Cytotoxic anti-melanocyte antibodies were found in the patient's serum, and this probably explains the development of the leucoderma.
THE SUCCESS OF REPEATED OPERATIONS UPON THE SAME NERVE, IN FACIAL NEURALGIA.
Authors: EDMUND ANDREWS
Journal: JAMA (1889)

Neurectomy performed for<i>tic douloureux</i>permanently cures some patients, and effectually stops the pain of nearly all the rest for a period of from six months to two years, yet the majority sooner or later relapse. Clinical experience has demonstrated to me the somewhat surprising fact that these relapsed cases may be freed from their pain over and over again by repeated operations at exactly the same spot, even though the surgeon fail utterly to get away any more tissue from the stump of the nerve. This result was unexpected to nie, for Ross and others who speak of repeating the neurectomy in relapsed cases seem, like myself, to have supposed it necessary to find the stump of the nerve and operate directly upon it. Clinical experience also shows the important fact that operations performed in the old cicatrix cause little or no shock or hemorrhage, and, while arresting the
280 RETREATMENT WITH PEG-IFN ALPHA-2A PLUS RIBAVIRIN FOR 48 WEEKS IN CHRONIC HEPATITIS C GENOTYPE 2 AND 3 RELAPSERS TO A PREVIOUS ANTIVIRAL TREATMENT
Authors: E. Minola, V. Baldo, T. Baldovin, A. Floreani
Journal: Journal of Hepatology (2010)
The New Chinese Medical Journal
Authors: TSUNG O. CHENG
Journal: Annals of Internal Medicine (1973)

Editorial Notes1 May 1973The New Chinese Medical JournalTSUNG O. CHENG, M.D., F.A.C.P.TSUNG O. CHENG, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-771 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe new Chinese Medical Journal, the official publication of the Chinese Medical Association of the People's Republic of China, finally made its debut in January of 1973. In view of the numerous exciting and new medical developments in China through recent years ( 1 ), including the revolutionary and innovative concept of "barefoot doctors" (2) and the successful integration of traditional Chinese medicine and modern Western medicine (3), this journal's rebirth was long overdue.I visited the People's Republic of China in May of 1972. Among the many striking findings that I came across in talking to medical colleagues and...References1. CHENG T: Changes in China (letter). N Engl J Med 287: 259, 1972 CrossrefMedlineGoogle Scholar2. CHENG T: China's barefoot doctors. Prism (AMA). In press Google Scholar3. CHENG T: Other China medical advances transcend use of acupuncture. Int Med News 5 (no. 20) : 1-32, 1972 Google Scholar4. CHENG T: A view of modern Chinese medicine. Observations by a Shanghai-born physician during his recent visit after 22 years of absence. Ann Intern Med 78:285-290, 1973 LinkGoogle Scholar5. CHENG T: Acupuncture anesthesia (letter). Science 179:521, 1973 CrossrefMedlineGoogle Scholar6. CHENG T: Chinese actively seek out early malignant tumors. Int Med News 5 (no. 21):3-22, 1972 Google Scholar7. CHENG T: Medical advances in People's Republic of China. Hosp Med. In press Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Cardiology Department of Medicine The George Washington University Medical Center Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChinese journals: a guide for epidemiologistsMedical Education and Practice in People's Republic of ChinaTSUNG O. CHENG, M.D., F.A.C.P., LLOYD AXELROD, M.D., ALEXANDER LEAF, M.D., F.A.C.P.Future Development of Chinese Medical JournalsTSUNG O. CHENG, M.D., F.A.c.P. 1 May 1973Volume 78, Issue 5Page: 771-772KeywordsChinese peopleTraditional Chinese medicine Issue Published: 1 May 1973 PDF DownloadLoading ...
Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice
Authors: M Huang
Journal: Cardiovascular Research (2003)

Objective: Interleukin-6 (IL-6) is elevated in the serum of patients with coronary artery disease (CAD) and acute coronary syndromes (ACS). Intracoronary release of IL-6 was reported in ACS that can also be triggered by acute stress. In rats, acute restraint stress increases serum IL-6 and histamine, both of which may derive from mast cells. The current study was carried out in order to determine any possible difference in stress-induced IL-6 release in atherosclerotic mice and the contribution of mast cells, corticotropin-releasing hormone (CRH) and urocortin (Ucn). Methods: C57BL/6J, W/Wv mast cell-deficient, Apolipoprotein E (ApoE) and CRH knockout (k/o) mice were stressed in plexiglass restraint chambers for 15 to 120 min. Serum corticosterone and IL-6 levels were measured. Some C57BL and ApoE k/o mice were pretreated with either the mast cell stabilizer disodium cromoglycate (cromolyn) or the peptide CRH receptor (CRH-R) antagonist Astressin. Cardiac mast cell activation was studied in both C57BL and ApoE k/o mice using light microscopy. Results: Acute stress increased serum IL-6 in mice, an effect much greater in ApoE k/o atherosclerotic mice. Stress-induced IL-6 release was absent in W/Wv mast cell-deficient mice and it was partially inhibited by cromolyn in C57BL and ApoE mice. Mast cells were found adjacent to atherosclerotic vessels in ApoE k/o mice and were activated after stress. CRH k/o mice released more IL-6 in response to stress than their wild types, but Astressin significantly inhibited IL-6 release. Stress-induced IL-6 release may, therefore, be at least partly due to peripheral Ucn and/or CRH, with Ucn possibly overcompensation for CRH deficiency. Conclusion: The present findings indicate that acute stress leads to mast cell-dependent serum IL-6 increase that may help explain stress-related coronary inflammation.
Thyroid function tests.
Authors: P Sheridan, R B Payne
Journal: BMJ (1978)

an objective remission in one patient who underwent hormonal ablation and was shown to be ER-negative, PgR-positive.I hope that the above-cited references will correct the impression that only ER-positive tumours contain PgR.Although the number of cases of PgR-positive, ER-negative tumours is small, they do exist.The importance of recognising this group of mammary carcinomas is that it may provide new insights into the interrelationship that exists between various hormones, their receptors, and tumour regression.
Caring for the Uninsured and Underinsured-Reply
Authors: Ronald S. Bronow
Journal: JAMA (1991)

In Reply.  —Dr Frankford suggests that relations between the Ontario government and its physicians have improved since the election of a socialist government in September 1990. It should be instructive to American physicians to examine the terms of the April 1991 agreement between the OMA and the Province of Ontario:   In 1988, the Ministry of Health, despite a prior agreement, unilaterally refused to grant cost-of-living fee increases to provincial physicians. The new agreement gives physicians a 2% lump sum payment for 1989-1990 and 1991-1992 gross billings (approximately one third of the increase in cost of living).    For the fiscal year 1991-1992, there is a 3.95% increase in fees for physicians' services—about 2% less than the rise in last year's consumer price index.  The OMA was forced to accept a  utilization  (a euphemism for global income capping). This creates a pool of funds available to fee-for-service physicians. If total
Continuous-flow plasmapheresis in management of severe rhesus disease.
Authors: J Graham-Pole, W Barr, M L Willoughby
Journal: BMJ (1977)

Eight patients with severe rhesus disease and expected fetal loss were treated by intensive plasmapheresis using a continuous-flow cell separator. Plasmapheresis was started at 16-27 weeks9 gestation, and continued until planned intrauterine transfusion or until the infant was delivered or the rhesus disease became uncontrolled again. Altogether 24 to 2371 of plasma was exchanged over periods ranging from seven to 16 weeks. In seven of the eight patients the anti-D concentration fell during the period of plasmapheresis. Amniotic fluid spectrophotometry values remained below those recorded in the preceding pregnancy in six out of seven women. In five patients an attempt was made to control the rhesus disease by plasmapheresis alone, and two of these women delivered infants who survived. In the other three cases the infants died, one from the idiopathic respiratory distress syndrome and the other two in utero. These preliminary findings suggest that intensive plasmapheresis with a cell separator may reduce fetal haemolysis is delivered. Nevertheless, plasmapheresis may best be used to reduce haemolysis until intrauterine transfusions may be given more safely after 30 weeks9 gestation.
1026-59 Elevated high-sensitivity C-reactive protein was associated with coronary artery remodeling in patients with unstable angina
Authors: Takahiro Tsuji, Masato Nakamura, Itaru Yokouchi, Atsushi Funatsu, Tsuyoshi Ono, Masanori Shiba, Masamichi Wada, Raisuke Iijima, Rintarou Nakajima, Masato Yamamoto, Hidehiko Hara, Hisao Hara, Takashi Yoshitama, Tarou Tsunoda, Kaoru Sugi
Journal: Journal of the American College of Cardiology (2004)
Risk of coronary heart disease in Hindus and Muslims from Indian subcontinent is similar
Authors: J D Maxwell, D P Strachan
Journal: BMJ (1996)

The anterior forebrain pathway (AFP) of the oscine song system is essential for song learning but not song production. Most cells recorded in this serially connected pathway show increased firing in response to song playback, suggesting largely excitatory connections among AFP nuclei. However, the neurons forming a key projection in this pathway, from area X to the medial nucleus of the dorsolateral thalamus (DLM), express glutamic acid decarboxylase in their somata and terminals, suggesting an inhibitory connection. To investigate the firing properties of DLM neurons and the functional influence of area X afferents in DLM, we made whole-cell recordings from DLM neurons in brain slices from adult male zebra finches. Most cells had intrinsic properties closely resembling those of mammalian thalamocortical cells, including a low-threshold Ca<sup>2+</sup> spike and time-dependent, hyperpolarization-activated inward rectification. Activation of afferents from area X evoked a strong, all-or-none IPSP whose amplitude and latency were unchanged by application of glutamate antagonists, consistent with a monosynaptic contact. The IPSP had a reversal potential near −70 mV and was blocked by the GABA<sub>A</sub> receptor antagonist bicuculline methiodide. Post-inhibitory rebound firing occurred in DLM neurons with a delay near 50 msec. Strong inhibition can combine with the intrinsic properties of DLM neurons to allow signaling on disinhibition. Our data are consistent with the hypothesis that the AFP corresponds to the mammalian corticobasal ganglia–thalamocortical loop. The similar functional properties of avian and mammalian thalamic neurons suggest conserved forebrain mechanisms of sensorimotor information processing across vertebrate taxa.
TURKISH BATH IN AMERICA.An Anniversary Address on Baths, Delivered at the Sanitarium Oct. 6, 1894.
Authors: CHARLES H. SHEPARD
Journal: JAMA (1894)

It is with no small measure of gratification that I greet you upon this, the thirtieth anniversary of the opening of the Turkish bath in this country. The old song had it that, "We are living in a grand and awful time!" These words were never more true than they are now. Between 1861, the beginning of our civil war, and 1893, the epoch of the Columbian Exposition, what a revelation the years have brought! The wonderful development of every department of knowledge, of all the resources of the country, have given a continual impetus to every element of progress, and all the refinements of civilization. Preeminent among these stands the Turkish bath. It is ennobled by a history which reaches back of records into tradition. During all that time the perfection of the bath was in exact proportion to the civilization of the country in which it was used.
Abstract 2188: The ubiquitin-specific protease USP2a targets cyclin A1: A potential role in bladder cancer
Authors: Jayoung Kim, Massimo F. Loda, Michael R. Freeman
Journal: Cancer Research (2012)

Abstract A deubiquitinating enzyme USP2a has shown oncogenic properties in many cancer types by impairing ubiquitination of FASN, MDM2, MDMX, or Aurora-A. Aberrant expression of USP2a has been linked to progression of human tumors, particularly prostate cancer. However, little is known about USP2a's role or mechanism in bladder cancer. Here we provide evidence that USP2a functions as an oncoprotein in bladder cancer cells. Overexpression of USP2a caused enhanced proliferation, invasion, migration, and resistance to several chemotherapeutic reagents, while USP2a loss resulted in slower proliferation, greater chemosensitivity, and reduced migratory/invasive capability, compared to control cells. USP2a, but not a catalytically inactive mutant, enhanced proliferation in immortalized TRT-HU1 normal human bladder epithelial cells. USP2a bound to cyclin A1 and prevented cyclin A1 ubiquitination, leading to accumulation of cyclin A1 by blocking its degradation. Enforced expression of wild type USP2a, but not an inactive USP2a mutant, resulted in cyclin A1 accumulation and increased cell proliferation. Our finding that USP2a impairs ubiquitination and stabilizes the important cell cycle regulator, cyclin A1, raises the possibility of USP2a silencing as a therapeutic strategy against bladder tumors in combination with chemotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2188. doi:1538-7445.AM2012-2188
Incidence of Herpes Zoster Ophthalmicus: Results from the Pacific Ocular Inflammation Study
Authors: Durga S. Borkar, Vivien M. Tham, Elizabeth Esterberg, Kathryn J. Ray, Aleli C. Vinoya, John V. Parker, Aileen Uchida, Nisha R. Acharya
Journal: Ophthalmology (2012)