tbuckley/cabot-search huggingface dataset:
Tc-99m DTPA Acetylsalicylic Acid (Aspirin) Renography in the Detection of Renovascular Hypertension
Authors: ESER LAY ERGÜN, MELTEM ÇAĞLAR, YUNUS ERDEM, CELALETTIN USALAN, ÖMER UĞUR, MURAT DURANAY
Journal: Clinical Nuclear Medicine (2000)

Purpose Prostaglandins play important roles in renal physiology and in the development of renovascular hypertension. In a recent study, inhibition of renal prostaglandin synthesis was found to be useful for detecting renovascular hypertension using renal scintigraphy. In the current study, the authors evaluated the role of aspirin (an inhibitor of prostaglandin synthesis) and compared it with Tc-99m DTPA captopril renal scintigraphy (CS). Materials and Methods Twenty-five patients were examined with Tc-99m DTPA in a three-step manner: a baseline study, CS, and aspirin scintigraphy (AS). Each scintigraphic study was interpreted visually and according to the renogram curve patterns. Semiquantitative parameters (Tmax, renal indices [%], 20-minute/max count ratio, glomerular filtration rate) were also calculated. Plasma renin activity was determined for each study. The blood pressures of all patients were measured during AS. All patients had a contrast-enhanced angiogram that was used as the reference test. Results Three groups of patients were observed based on the scintigraphic and angiographic results. In each group, no difference was observed in blood pressure after aspirin administration. In group 1, seven patients had normal angiographic and scintigraphic results. In group 2, eight patients had angiographically confirmed renal artery stenosis (RAS). In 6 patients (mean, 47% RAS), both AS and CS were negative for RVH. In the remaining two patients with RAS (mean, 83% stenosis), the kidneys were atrophic on the stenotic side, and thus the kidneys did not respond to the interventions. No difference was observed in plasma renin activity in groups 1 and 2. Group 3 included 10 patients who had angiographically confirmed RAS (mean, 86%). In 9 patients, both CS and AS were positive for RVH. In the remaining one patient, scintigraphic results were falsely negative. Statistical analyses performed for semiquantitative parameters did not reveal any significant difference in this group, although there was a tendency toward prolonged Tmax values after captopril and aspirin administration. In four cases, unexpected elevation of plasma renin activity was observed in group 3. Conclusions These data indicate that AS with Tc-99m DTPA is an alternative for CS. It has the advantage of having no effect on blood pressure and does not require that angiotensin-converting enzyme inhibitors be discontinued. Although in this study 9 of 10 patients had correct diagnoses of RAS, further studies, especially using tubular agents with the calculation of parenchymal transit time, might provide valuable information in this patient group. An ongoing study is being performed in the authors’ institute.
Abstract LB-341: Cysteine dioxygenase 1 is a tumor suppressor gene silenced by promoter methylation in multiple human cancers
Authors: Mariana Brait, Shizhang Ling, Jatin Nagpal, Xiaofei Chang, Hannah Park, Juna Lee, Jun Okamura, Keishi Yamashita, David Sidransky, Myoung Sook Kim
Journal: Cancer Research (2012)

Abstract The human cysteine dioxygenase 1 (CDO1) gene is a non-heme structured, iron-containing metalloenzyme involved in the conversion of cysteine to cysteine sulfinate, and plays a key role in taurine biosynthesis. In our search for novel methylated gene promoters, we have analyzed differential RNA expression profiles of colorectal cancer (CRC) cell lines with or without treatment of 5-aza-2′-deoxycytidine. Among the genes identified, the CDO1 promoter was found to be differentially methylated in primary CRC tissues with high frequency compared to normal colon tissues. In addition, a statistically significant difference in the frequency of CDO1 promoter methylation was observed between primary normal and tumor tissues derived from breast, esophagus, lung, bladder and stomach. Downregulation of CDO1 mRNA and protein levels were observed in cancer cell lines and tumors derived from these tissue types. Expression of CDO1 was tightly controlled by promoter methylation, suggesting that promoter methylation and silencing of CDO1 may be a common event in human carcinogenesis. Moreover, forced expression of full-length CDO1 in human cancer cells markedly decreased the tumor cell growth in an in vitro cell culture and/or an in vivo mouse model, whereas knockdown of CDO1 increased cell growth in culture. Our data implicate CDO1 as a novel tumor suppressor gene and a potentially valuable molecular marker for human cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-341. doi:1538-7445.AM2012-LB-341
Gadolinium as an alternative contrast agent for therapeutic ERCP in the iodine-allergic patient
Authors: C. Lawrence, P. Cotton
Journal: Endoscopy (2009)

Performance of endoscopic retrograde cholangiopancreatography (ERCP) requires an intraductal contrast agent. The contrast of choice is an iodine-based agent. The alternatives in patients with a severe allergy to iodinated contrast are limited. We undertook a retrospective review of the success and safety of gadolinium as an alternative radiocontrast agent in patients with allergy to iodine-based contrast in a series of five patients in a tertiary care pancreaticobiliary referral center. The five patients underwent a total of six ERCP procedures using a gadolinium chelate as the radiocontrast agent. ERCP was technically successful in all cases, including pancreatic endotherapy. There were no contrast-related adverse reactions. Gadolinium is concluded to be a reasonable alternative to iodine-based ERCP contrast in selected patients. It provides inferior image quality compared to standard iodine-based contrast but was not technically limiting in our small experience.
NHS recommends doctors apologise when treatment goes wrong
Authors: C. Dyer
Journal: BMJ (2009)

Doctors should apologise and provide explanations to patients and their relatives when treatment goes wrong, according to guidance from the NHS Litigation Authority, the body which defends the NHS against legal claims for clinical negligence.

The letter from Stephen Walker, the authority’s chief executive, replaces an earlier circular that warned NHS bodies to take care when providing explanations “so as to avoid future litigation risks.”

His new guidance says, “It is most important to patients that they or their relatives receive a meaningful apology. We encourage this, and stress that apologies …
Les migraines psychosomatiques
Authors: P. Jonckheere
Journal: Psychotherapy and Psychosomatics (1972)

The author has based his research on 3 principles: (1) It is necessary to form a control group; (2) it is useful to limit the case material to patients who have been in psychotherapy for at least several months; (3) specificity must be expressed in terms of levels. Conclusions: (1) Often chronic headache and migraines are due to repressed aggression; (2) the heart infarction may occur under a circumstance which suddenly strikes the patient in his basic ambitions; (3) the hypertension patients present a type of personality characterized by constant hurry, psychic tension, hyperactivity and hyperemotivity; (4) the analogies between the patients suffering from migraines, hypertension, cardial infarction, obsessional neurosis, etc. do not conflict with the theories of specificity, yet they illustrate the necessity of a multifactorial approach.
Replication of smooth muscle cells in vascular disease.
Authors: S M Schwartz, G R Campbell, J H Campbell
Journal: Circulation Research (1986)

Smooth muscle proliferation has been recognized as central to the pathology of both major forms of vascular disease: atherosclerosis and hypertension. Recent advances in our knowledge of mechanisms of control of proliferation suggest that events occurring in adult animals may recapitulate portions of the developmental biology of the smooth muscle cell. This review attempts to consider the current state of knowledge of the mechanisms controlling smooth muscle proliferation in these two diseases, to put that knowledge into the context of what is known about smooth muscle biology, and to offer two hypotheses on the possible roles of smooth muscle developmental biology in manifestations of atherosclerosis and hypertension in adult humans.
MENINGITIC SYMPTOMS RAPIDLY FOLLOWING LUMBAR PUNCTURE AND RAPIDLY DISAPPEARING
Authors: WILLIAM G. SPILLER
Journal: JAMA (1924)

Infection of the spinal meninges following lumbar puncture has been reported in rare instances, but we have never previously observed, nor found recorded in the literature, that severe symptoms of meningitis, with many polymorphonuclear cells in the spinal fluid, may follow lumbar puncture within a few hours and disappear in little more than twenty-four hours after their first appearance. This, however, was our experience recently, and the case caused us great anxiety for a short time. It seemed to us that possibly the meningeal blood vessels were congested from the epileptic attacks, as such congestion is not infrequent in convulsions, and that, as a result of relief of pressure, even though slight, by lumbar puncture, escape of blood cells, possibly by diapedesis, occurred and caused meningeal irritation. We have asked for information from three well known serologists, Drs. Herbert Fox, F. B. Lynch and John A. Kolmer, and not one
THE MEDICO-LEGAL ASPECT OF EYE AND EAR CASES.
Authors: J. WALTER PARK
Journal: JAMA (1896)

The subject chosen for my paper is one of special interest to me, and I feel assured it will be to the general practitioner, if I succeed in impressing upon your minds the necessity of a certain professional relationship which should exist between the general practicing physician and the specialist, in the examining and treatment of accidental eye and ear injuries, preparatory to what may become medico-legal cases. My subject is such an extensive one, that I will confine my remarks more particularly to accidental injuries. I wish to call your attention to the following points of interest: 1, the kind of an examination, and record of the case, that should be made by the physician in attendance at the time of the injury; 2, the kind of cases which should be examined by a specialist, or one skilled in the treatment of diseases and injuries of the eye and
Chest Pain and an Angiographic Abnormality
Authors: Vijaya L. Rao, Vibhav Rangarajan
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High Levels of Dietary Advanced Glycation End Products Transform Low-Dersity Lipoprotein Into a Potent Redox-Sensitive Mitogen-Activated Protein Kinase Stimulant in Diabetic Patients
Authors: Weijing Cai, John Cijiang He, Li Zhu, Melpomeni Peppa, Changyong Lu, Jaime Uribarri, Helen Vlassara
Journal: Circulation (2004)

Background— LDL modification by endogenous advanced glycation end products (AGEs) is thought to contribute to cardiovascular disease of diabetes. It remains unclear, however, whether exogenous (diet-derived) AGEs influence glycoxidation and endothelial cell toxicity of diabetic LDL. Methods and Results— Twenty-four diabetic subjects were randomized to either a standard diet (here called high-AGE, HAGE) or a diet 5-fold lower in AGE (LAGE diet) for 6 weeks. LDL pooled from patients on HAGE diet (Db-HAGE-LDL) was more glycated than LDL from the LAGE diet group (Db-LAGE-LDL) (192 versus 92 AGE U/mg apolipoprotein B) and more oxidized (5.7 versus 1.5 nmol malondialdehyde/mg lipoprotein). When added to human endothelial cells (ECV 304 or human umbilical vein endothelial cells), Db-HAGE-LDL promoted marked ERK1/2 phosphorylation (pERK1/2) (5.5- to 10-fold of control) in a time- and dose-dependent manner compared with Db-LAGE-LDL or native LDL. In addition, Db-HAGE-LDL stimulated NF-κB activity significantly in ECV 304 and human umbilical vein endothelial cells (2.3-fold above baseline) in a manner inhibitable by a MEK inhibitor PD98059 (10 μmol/L), the antioxidant N -acetyl- l -cysteine, NAC (30 mmol/L), and the NADPH oxidase inhibitor DPI (20 μmol/L). In contrast to Db-LAGE-LD and native LDL, Db-HAGE-LDL induced significant soluble vascular cell adhesion molecule-1 production (2.3-fold), which was blocked by PD98059, NAC, and DPI. Conclusions— Exposure to daily dietary glycoxidants enhances LDL-induced vascular toxicity via redox-sensitive mitogen-activated protein kinase activation. This can be prevented by dietary AGE restriction.
Neutralizing antibody directed against the HIV–1 envelope glycoprotein can completely block HIV–1/SIV chimeric virus infections of macaque monkeys
Authors: Riri Shibata, Tatsuhiko Igarashi, Nancy Haigwood, Alicia Buckler–White, Robert Ogert, William Ross, Ronald Willey, Michael W. Cho, Malcolm A. Martin
Journal: Nature Medicine (1999)
Mercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin-4.
Authors: P Prigent, A Saoudi, C Pannetier, P Graber, J Y Bonnefoy, P Druet, F Hirsch
Journal: Journal of Clinical Investigation (1995)

Mercurials may induce immune manifestations in susceptible individuals. Mercuric chloride (HgCl2) induced autoimmunity in the Brown Norway (BN) strain but an immuno-suppression in the Lewis strain with, however, autoreactive anti-class II T cells present in both strains. In the present study we looked at modifications of cytokine production by PCR and cytofluorometric analyses in normal BN and Lewis rat splenocytes, cultured with or without HgCl2. Unfractionated BN rat splenocytes and purified T cells exposed to HgCl2 expressed high levels of IL-4 mRNA. Increase in class II and CD23 molecule expression on B cells was partly inhibited by anti-IL-4 mAb showing that IL-4 was produced. By contrast, no overexpression of IL-4 mRNA could be seen in Lewis rats. Although an increase in class II molecule expression was observed suggesting that other T helper cell 2 cytokines were produced, there was also a concomitant decrease in CD23 molecule expression that was abrogated after addition of an anti-IFN-gamma mAb to the culture. IFN-gamma mRNA production was induced in unfractionated spleen cells and T cells from both strains after HgCl2 exposure. Altogether these findings demonstrate that HgCl2 has very early direct effects on cytokine production and that these effects differ depending on the strain. The early effect on IL-4 production observed on BN rat spleen cells and T cells may explain that the autoreactive anti-class II T cells that are found in HgCl2-injected BN rats have a Th2 phenotype.
Abstract 2324: Phospho-MED1 mediates the transcriptional regulation of AR splice variants in castration-resistant prostate cancer
Authors: Gang Liu, Cynthia Sprenger, Pin-Jou Wu, Shihua Sun, Takuma Uo, Kathleen Haugk, Kathryn Soriano Epilepsia, Stephen Plymate
Journal: Cancer Research (2014)

Abstract The appearance of constitutively active androgen receptor splice variants (AR-Vs) has been proposed as one of the causes of castration-resistant prostate cancer (CRPC). Prior to treatment with enzalutamide or abiraterone, around 20-30% of CRPC patients already have high levels of AR-Vs in their metastases, especially ARv567es, and this portends a rapid progression and shorter survival. However, the underlying mechanism of AR-Vs in CRPC transcriptional regulation still remains unclear. A distinct transcriptome enriched with cell cycle genes (like UBE2C) has been associated with AR-Vs, which indicates the possibility of a different transcriptional mechanism than that of wild type AR. In our study, we performed co-immunoprecipitation, ChIP and luciferase reporter assays to explore the components involved in ARv567es activated UBE2C transcription. We found that (i) MED1 is necessary for ARv567es induced UBE2C up-regulation and subsequent prostate cancer cell growth; (ii) p-MED1 is recruited to ARv567es independent of full-length AR; (iii) p-MED1 has higher recruitment to UBE2C promoter and enhancer regions in the presence of ARv567es, (iv) ARv567es enhanced UBE2C transcription could be blocked by silencing MED1; (v) ARv567es/p-MED1 signaling cross talks with the PI3K-AKT pathway but not the MAPK pathway, and (vi) FoxA1 and histone methylation are involved in ARv567es/p-MED1 induced UBE2C long range chromatin interactions. In summary, these data indicate that p-MED1 serves as a key mediator in ARv567es transcriptional regulation and suggests a mechanism by which AR-Vs promote the development and progression of CRPC. Citation Format: Gang Liu, Cynthia Sprenger, Pin-Jou Wu, Shihua Sun, Takuma Uo, Kathleen Haugk, Kathryn Soriano Epilepsia, Stephen Plymate. Phospho-MED1 mediates the transcriptional regulation of AR splice variants in castration-resistant prostate cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2324. doi:10.1158/1538-7445.AM2014-2324
Medical Significance of the Census
Authors: W. P. D. Logan
Journal: BMJ (1951)

BDICA JOURNALstatistical information available about them, but preci- sion will be given to the material on which social scientists are already working.It is perhaps not possible to look to the results of the 1951 census with that same degree of uncertainty which must have whetted the appetite of the curious in 1801 and 1811, but to all who are interested in the material problems of our society the coming census will clearly have much to offer; and, if a conclusion may be made on a note of paradox, it is interesting to observe that, whereas the Britain of 1801 with its population of 11 millions sought statistical information on what it deemed to be its problems of over-population and an excessive birth rate, to-day, with a population more than four times as numerous, it is a low birth rate and a consequent reduction in population growth that causes most general concern.
Child and Adolescent Psychiatry: Modern Approaches
Authors: Thomas F. Anders
Journal: JAMA (1985)

Nine years after the publication of the first edition of<i>Child Psychiatry: Modern Approaches</i>, Rutter and Hersov have published a greatly expanded and totally revised second edition. Even the title reflects its broadened scope. As was true for the first edition, the second edition will be the resource text for the field. Each chapter has been updated and revised. Sections have been expanded and reflect major changes in the field. The breadth of authors now reflects a broader representation of international contributors. And, finally, the subject matter covers the major principles and theories of child development, the contributions of developmental psychopathology research, the clinical syndromes extending from infancy through adolescence, and multimodal treatment approaches. Clearly, this is an international and interdisciplinary labor of love. Although at first glance the number of pages in the first and second editions seems comparable, the second edition is characterized by larger pages, smaller print,
Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis
Authors: Domenico Sansonno, Felicia Anna Tucci, Laura Troiani, Gianfranco Lauletta, Michele Montrone, Vincenza Conteduca, Loredana Sansonno, Franco Dammacco
Journal: Blood (2008)
AN IRRIGATING PROCTOSIGMOIDOSCOPE
Authors: Joseph M. Marcus
Journal: JAMA (1924)

This appartus consists of an obdurator, tube, combination of light-carrier and lamp, telescope and irrigating apparatus. The obdurator has an olivary tip, which facilitates the introduction of the tube. The tube is 10 inches long, with a working length of 8 inches. Its distal end is oblique, and the proximal end is fitted with a large flange with a milled edge. A small segment is cut from one side to prevent rolling. A metallic plug closes the proximal opening by a conical fitting, and contains two openings. The upper opening is for the irrigating tube, which contains the light carrier and telescope. The lower opening is for the outflow tube. The latter aperture can be closed by a metallic plug containing a lens as a glass window, which magnifies the illuminated field at the distal end of the tube. The light-carrier is unique in that it has a telescopic arrangement
Treating malignant otitis with oral ciprofloxacin.
Authors: J. Fairley, G. W. Glover
Journal: BMJ (1989)

ments made on a different occasion in awake children' and one study of adults in which no intra-arterial measurements were made.4We suggested using a maximum width cuff for convenience: it is easier to put the widest cuff possible on a child's arm than to refer to a chart based on measurements of the child's arm circumference.We accept that blood pressure is likely to vary with cuff size even with our criteria, but we believe that our technique is simple and that overestimation of blood pressure from too small a cuff is much more common than underestimation with a large cuff.We agree that cuff size should be varied as little as possible.
LEFT VAGUS NERVE STIMULATION SIGNIFICANTLY ATTENUATES VENTRICULAR DYSFUNCTION AND INFARCT SIZE THROUGH PREVENTION OF MITOCHONDRIAL DYSFUNCTION DURING ACUTE ISCHEMIA-REPERFUSION INJURY IN SWINE
Authors: Krekwit Shinlapawittayatorn, Kreokkiat Chinda, Siripong Palee, Sirirat Surinkaew, Kittiya Thunsiri, Punate Weerateerangkul, Siriporn Chattipakorn, Bruce H. KenKnight, Nipon Chattipakorn
Journal: Journal of the American College of Cardiology (2013)
Proctocolectomy without ileostomy for ulcerative colitis.
Authors: A G Parks, R J Nicholls
Journal: BMJ (1978)

An operation has been developed that permits total removal of all disease-prone mucosa in ulcerative colitis but avoids the need for a permanent ileostomy. The colon and upper half of the rectum are excised and the remaining inflamed mucosa is stripped from the rectal stump down to the dentate line of the anal canal. A pouch is fashioned from a triplicated loop of terminal ileum. This is drawn down through the denuded rectum and an anastomosis created, via the per-anal approach, between the ileum just distal to the pouch and the mid-anal canal. A temporary ileostomy is made. Out of eight patients so treated, five were available for assessment, and four of them were highly satisfied with the result in improved health and function. The remaining three were awaiting closure of their ileostomies.