tbuckley/cabot-search huggingface dataset:
Internalization of the 180 kDa bullous pemphigoid antigen as immune complexes in basal keratinocytes: an important early event in blister formation in bullous pemphigoid
Authors: None Kitajima, None Nojiri, None Yamada, None Hirako, None Owaribe
Journal: British Journal of Dermatology (1998)

We have previously shown that the 180 kDa bullous pemphigoid antigen (BPAG2) is distributed on the lateral-apical (as a pool) and ventral (as hemidesmosomes) cell membranes of monolayer cultured keratinocytes and that addition of IgG purified from bullous pemphigoid (BP) patients (BP-IgG) causes the internalization of immune complexes of BPAG2 and BP-IgG from the lateral-apical cell membrane. This internalization of BPAG2 is believed to inhibit the Ca2+ induced reformation of hemidesmosomes on the ventral cell membrane, possibly by inhibiting the supply of the antigen from the lateral-apical to the ventral membranes to form hemidesmosomes. The purpose of this paper is to examine, by using biopsy specimens from BP patients (12 cases), whether or not this internalization of BPAG2 is generated in situ. The fates of BPAG2, 230 kDa BPA (BPAG1) and bound BP-IgG were traced by immunofluorescence microscopy using monoclonal antibodies to BPAG1, BPAG2 and human IgG. In more than half of the lesional and perilesional biopsy specimens, internalization of BPAG2 into the basal cells was observed, while in normal skin BPAG2 was detected on the whole surface of the basal cells without its internalization. No internalization of BPAG1 was detected in BP and normal epidermis. These results suggest that binding of BP-IgG on the lateral-apical cell surface of basal cells causes internalization of BPAG2 in situ in the epidermis of BP patients similar to that seen in cultured cell systems, and that this internalization of immune complexes of BPAG2 and BP-IgG may play an important part in blister formation in BP.
Endoscopic Argon Plasma Trimming of Biliary and Gastrointestinal Metallic Stents
Authors: G. Vanbiervliet, T. Piche, F. Caroli-Bosc, R. Dumas, E. Peten, P. Huet, A. Tran, J. Demarquay
Journal: Endoscopy (2005)

The aim of this study was to assess the feasibility and efficiency of plasma argon trimming of gastrointestinal and biliary metallic stents.A total of 31 patients underwent plasma argon trimming of their metallic stents (14 women, 17 men; mean +/- SD age 73 +/- 12.2 years, range 46 - 96 years). Of these 31 patients, 24 had had covered or noncovered Unistep Wallstents placed in the biliary tract (13 patients with pancreatic neoplasms, five patients with Vater ampulloma, five patients with biliary tract carcinoma and one patient with chronic calcifiying pancreatitis); three patients had noncovered Enteral Unistep Wallstents (pyloroduodenal); two patients with obstructive colorectal carcinoma had a noncovered Bard Memotherm stent inserted; and two patients had noncovered Ultraflex stents placed for esophageal carcinoma. Endoscopic trimming of the stents was performed under propofol-induced general anesthesia, with the power set at 70 - 80 watts and an argon flow of 0.8 liters/minute.Complete and satisfactory trimming of the stents was possible, without complications (mean follow-up 15.8 months), in all patients except one, a patient with a covered biliary Wallstent. In 13 patients with biliary or Enteral Wallstents the trimming procedure was preventive. In eight patients with ulceration and/or hemorrhage (duodenal or rectal), healing was achieved after stent trimming and epinephrine (adrenaline) injection followed by electrocoagulation. Stent trimming restored patency of the duodenal lumen in six patients and of the esophageal lumen in two patients, and was done to allow insertion of a biliary stent in one patient whose duodenal stent was covering the papilla. In one patient with rectal tenesmus, stent shortening resulted in complete resolution of symptoms.Endsocopic plasma argon trimming of metallic stents is an efficient procedure which allows easy, reproducible and well-tolerated correction of complications that arise due to these prostheses.
Bodyworks: An Adventure in Anatomy
Authors: Stanley W. Jacob
Journal: JAMA (1993)

A guided tour of the human body might not be everyone's idea of a fun trip, but a new computer program called Bodyworks makes the journey through the labyrinth of human anatomy and physiology interesting, full of intriguing sidetrips, and, most of all, indeed fun.   Bodyworks is user friendly and easily learned just by experimenting with it. It lets users meander through the body's different internal systems—skeletal, muscular, nervous, digestive, lymphatic, endocrine, cardiovascular, and reproductive—at their own speed and by whatever erratic path chosen, letting one item lead to another according to particular interest. The user can zoom out to look at the whole body, select a physiological subsystem, and then zoom in for a close look at a special organ area. The program also provides several special, easily accessible subsections-tooth, breast, brain areas, etc. The online dictionary also facilitates self-learning by bringing up the appropriate screen for an immediate
A CASE OF WANDERING ŒDEMA
Authors: BERNHARD SMITH
Journal: British Journal of Dermatology (1901)

Journal Article A CASE OF WANDERING ŒDEMA Get access BERNHARD SMITH BERNHARD SMITH Surgeon P. and O. Steam Navigation Company Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 13, Issue 8, 1 August 1901, Page 309, https://doi.org/10.1111/j.1365-2133.1901.tb16399.x Published: 01 August 1901
Expression of CEACAM6 in Resectable Colorectal Cancer: A Factor of Independent Prognostic Significance
Authors: Peter Jantscheff, Luigi Terracciano, Adam Lowy, Katharina Glatz-Krieger, Fritz Grunert, Burkhard Micheel, Jens Brümmer, Urs Laffer, Urs Metzger, Richard Herrmann, Christoph Rochlitz
Journal: Journal of Clinical Oncology (2003)

CEACAM6, CEACAM1, and human carcinoembryonic antigen (CEA) are coexpressed in normal colorectal epithelia, but show deregulated expression in colorectal cancers (CRC). Upregulation of CEACAM6 expression in hyperplastic polyps and early adenomas represents one of the earliest observable molecular events leading to colorectal tumors. The aim of our study was to evaluate the prognostic relevance of CEACAM6, CEACAM1, and CEA tissue expression in patients with CRC.Immunohistochemical analysis was carried out on tissue microarrays from 243 paraffin-embedded biopsies from a randomized controlled clinical trial (Swiss Group for Clinical Cancer Research [SAKK] 40/81) of adjuvant fluorouracil-based chemotherapy with CEACAM-specific monoclonal antibodies. The median follow-up was 8 years. Overall survival (OS) and disease-free survival (DFS) were calculated using Kaplan-Meier estimates and hazard ratios (HRs) estimated using Cox proportional hazards models.Tissue expression of CEACAM6, CEACAM1, and CEA was enhanced in 55%, 58%, and 94% of patients, respectively. Multivariate Cox analysis including sex, age, tumor site, stage, differentiation grade, treatment, and nodal status as covariates showed that CEACAM6 overexpression independently predicted poor OS (HR, 1.86; P =.0100) and DFS (HR, 2.00; P =.0028), whereas CEACAM1 or CEA were not significantly related to these outcomes. The data did not provide evidence for or against the hypothesis that the CEACAM6 effect on survival differs according to treatment.Expression of the cell adhesion molecule CEACAM6 in CRC is an independent prognostic factor allowing subdivision of patients into low- and high-risk groups. Whether CEACAM6 or CEA and CEACAM1 might be useful as predictive markers of chemotherapy benefit remains unclear.
Diseases of the central nervous system. Relief of pain: headache, facial neuralgia, migraine, and phantom limb.
Authors: J D Parkes
Journal: BMJ (1975)

Nodules commonly occur in rheumatoid arthritis and occasionally give rise to complications.The sacral nodule is easily missed and may ulcerate to produce extensive sacral sores which may lead to serious and even fatal complications in patients with rheumatoid arthritis.Seven cases are reported which illustrate some of these features.
Mutations in the human α-tectorin gene cause autosomal dominant non-syndromic hearing impairment
Authors: Kristien Verhoeven, Lut Van Laer, Karin Kirschhofer, P. Kevin Legan, David C. Hughes, Isabelle Schatteman, Margriet Verstreken, Peter Van Hauwe, Paul Coucke, Achih Chen, Richard J.H. Smith, Thomas Somers, F. Erwin Offeciers, Paul Van de Heyning, Guy P. Richardson, Franz Wachtler, William J. Kimberling, Patrick J. Willems, Paul J. Govaerts, Guy Van Camp
Journal: Nature Genetics (1998)
Growth cone advance is inversely proportional to retrograde F-actin flow
Authors: Chi-Hung Lin, Paul Forscher
Journal: Neuron (1995)

In a previous study, F-actin appeared to play a key role in guiding microtubules during growth cone-target interactions. Here, F-actin flow patterns were assessed to investigate the relationship among F-actin flow, microtubule/organelle protrusion, and rates of outgrowth. We first demonstrated conditions in which surface markers (beads) moved at the same rate as underlying F-actin. These beads were then positioned, using laser tweezers, to assess F-actin movements during target interactions. We found retrograde F-actin flow was attenuated specifically along the target interaction axis in direct proportion to the rate of growth cone advance. Retrograde actin flow adjacent to the interaction axis was unperturbed. Our results suggest that growth cones transduce retrograde F-actin flux into forward movement by modulating F-actin-substrate coupling efficiency.
Dipyridamole echocardiography test. A new tool for detecting jeopardized myocardium after thrombolytic therapy.
Authors: L Bolognese, G Sarasso, A S Bongo, L Rossi, D Aralda, C Piccinino, P Rossi
Journal: Circulation (1991)

We wished to assess whether dipyridamole echocardiography test (DET) can detect jeopardized myocardium after thrombolytic therapy.Seventy-six consecutive patients with a first acute myocardial infarction (AMI) were treated with 2 million IU urokinase i.v. within 4 hours of the onset of AMI and underwent high-dose (as much as 0.84 mg/kg over 10 minutes) DET 8-10 days after AMI. The results were correlated to the anatomy of the infarct-related vessel (IRV). In patients with positive DET, we evaluated the wall motion score index (WMSI; a semiquantitative integrated estimation of extent and severity of the stress-induced dyssynergy). WMSI was derived by summation of individual segment scores divided by the number of interpreted segments. In a 13-segment model, each segment was assigned a score ranging from 1 (normal) to 4 (dyskinetic). Fifty-three patients had positive results on DET. Of these, 42 had dipyridamole-induced new wall motion abnormalities (WMAs) confined to the infarct zone or adjacent segments. In these patients, mean WMSI increased from 1.46 +/- 0.26 (at resting conditions) to 1.73 +/- 0.35 (at peak dipyridamole) (p less than 0.01), whereas no significant change was detected in negative patients (1.6 +/- 0.34 versus 1.57 +/- 0.34, p = NS). Coronary angiography showed a patent IRV (TIMI grade 2 or 3) in 53 patients and no or minimal reperfusion (TIMI grade 0 or 1) in 23 patients. A patent IRV with critical residual stenosis was found in 35 of 42 patients with dipyridamole-induced WMAs in the infarct zone and in 18 of 34 patients without WMAs (p less than 0.05). Among the 23 patients with occluded IRVs, nine had collateral flow to the distal vessel; six of these had a positive DET. Thus, the sensitivity and specificity for identifying a critically stenotic but patent IRV or the presence of a collateral-dependent zone were 66% and 93%, respectively. In a subset of nine patients with a positive DET in the infarct zone or adjacent segments, DET and a control coronary angiography were repeated 1-3 months after an angiographically successful (residual stenosis, 50% or less) coronary angioplasty in the IRV. The repeat DET was negative in eight patients (all with patent IRV at control angiography) and again positive in one patient, who showed restenosis at angiography. The WMSI, at resting conditions was similar before and after angioplasty, whereas it differed significantly at peak dipyridamole (1.7 +/- 0.2 versus 1.4 +/- 0.2, p less than 0.01).DET can identify the anatomy of the IRV, and dipyridamole-induced WMAs within the infarct zone detect regions with jeopardized myocardium that may benefit from intervention.
STUDIES IN EXPERIMENTAL SYPHILIS
Authors: Alan M. Chesney, Charles R. L. Halley, Jarold E. Kemp
Journal: The Journal of Experimental Medicine (1927)

Syphilitic rabbits, whether untreated or treated after the 90th day of infection, were found to be more refractory to subsequent inoculation with the homologous strain of Treponema pallidum than to inoculation with heterologous strains of the same organism, when clinical criteria alone were employed in judging the outcome of reinoculation. The incidence of second infection with homologous strains was 5.4 per cent, as against 50 per cent with heterologous strains.(2) The resistance which develops in rabbits during the course of a syphilitic infection appears therefore to be strain-specific rather than species-specific. The protection afforded against homologous strains was found to persist for at least as long as 6 months after treatment was discontinued. A given strain may afford a higher degree of protection against some strains than against others, but whether this is to be explained upon the basis of biologic relationship or of differences in virulence, or possibly as the result of both of these factors was not disclosed by the experiments. Rabbits infected with a strain (Nichols) which had been adapted to this species for over a decade could be infected with strains which had been recovered recently from the human body. The previous existence of a syphilitic lesion in the testis which was used as the site for reinoculation did not seem to exert any influence upon the incidence of successful second infections obtained with heterologous strains of Treponema pallidum. Sometimes the course of the second infection produced by inoculation with heterologous strains was less pronounced than that observed in the controls, but in most instances no significant alteration was observed. In syphilitic rabbits treated late in the course of the disease and reinoculated with heterologous strains of Treponema pallidum no lesion may develop at the site of reinoculation but nevertheless the Wassermann reaction may become positive and remain so for weeks thereafter. It is suggested that such animals may be examples of asymptomatic reinfection.
Jerrold Ross Burgess Coralie Rendle-Short John Hamilton Ross John Alexander Shearer Ann Woolcock
Authors: K. Monaghan
Journal: BMJ (2001)

Routine audit is an ethical requirement of screeningEditor-Cervical screening saves about 1300 lives each year in England and Wales. 1 We regard audit as an essential part of the screening programme and urge health authorities to continue this activity despite recent concerns about using patient information without informed consent.Poor quality screening is ineffective and may do more harm than good.Women screened in the NHS can expect a high quality service in which smears are properly taken and read to a high standard and the results stored to ensure appropriate management.Audit is part of the quality assurance that is integral to the screening that each woman receives.
Advertisements highlight MSD's inappropriate hospitality
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

Merck Sharp & Dohme (MSD) became the first company in the UK to be publicly admonished after a breach of the drug industry's revised code of practice.

After a finding that the company had entertained doctors and their spouses at a meeting with no clear educational content in an unsuitable venue, the Prescription Medicines Code of Practice Authority placed advertisements in two medical publications, including the BMJ .

An anonymous complainant tipped off the authority about the incident, which took place in a Chinese restaurant in December 2005. Photographic evidence supplied …
1163-115 Traditional risk factors are associated with regional left ventricular dysfunction in asymptomatic individuals: The multi-ethnic study of atherosclerosis (MESA)
Authors: Boaz D Rosen, Mohammed Saad, Steve Shea, Khurram Nasir, Thor Edvardsen, Michael Jerosch-Herold, Shenghan Lai, David A Bluemke, Joao A.C Lima
Journal: Journal of the American College of Cardiology (2004)
Uses of Hyperimmune Human Gamma Globulin
Authors: Elvin A. Kabat
Journal: New England Journal of Medicine (1963)

THE differentiation of immune from hyperimmune gamma globulin is, of course, completely arbitrary since the antibodies present in human gamma globulin are all a result of accidental or deliberate contact with infectious agents and other antigens. In a conference on gamma globulin and its potential uses in medicine, and especially for those problems affecting the Department of Defense, one should not lose sight of the long-range view in the elimination or prevention of various diseases. In this respect gamma globulin, although providing prophylaxis of short duration or therapy, frequently yields important clues to potential methods of active immunization.Thus, the . . .
Master's Test vs Angiogram
Authors: DAVID L. FREEMAN
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 July 1971Master's Test vs AngiogramDAVID L. FREEMAN, M.D.DAVID L. FREEMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-1-137_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: FitzGibbon and associates (Ann Intern Med74:509-517, 1971) amply demonstrate the poor correlation between Master's test and angiogram. They neglect, however, to interpret their data to evaluate the validity of the Master's test in the patient with angina and no other clinical or cardiographic signs of coronary artery disease. They list one such group of patients with "no known infarction" (32 patients in Table 7, 38 in the methods section). How well does the Master's test and angiography correlate in this particular group and its subgroups of symptom severity?...Reference1. ROITMANJONESSHEFFIELD DWL: Comparison of submaximal exercise ECG test with coronary cineangiocardiogram. Ann Intern Med 72:641-647, 1970 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID L. FREEMAN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1971Volume 75, Issue 1Page: 137-138KeywordsAnginaAngiographyInfarctionPatientsStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 July 1971 PDF downloadLoading ...
Prescription Charge Anomalies
Authors: D. W. Smith
Journal: BMJ (1973)

tory difficulty at birth and pulmonary function tests were normal.I would like to point out that my colleagues and II 2 have suggested that the predelivery amniotic fluid lecithin concentration of 3-5 mg/100 ml is associated with practically no risk of neonatal respiratory distre-ss syndrome.As far as I can judge this is confirrmed by the findings of these workers.This critical lecithin level indicates the earliest time when the fetus in jeopardy can be delivered without the risk of de-
Medical services to the aborigines in West Malaysia.
Authors: J. M. Bolton
Journal: BMJ (1968)

Left to themselves in the jungle of West Malaysia, the aborigines lived in a world of their own until they became politically important as pawns in the Malayan emergency.For military reasons a medical service for the aborigines was started by the Colonial Administration in 1955.This service has been expanded as part of the independent Malaysian Government's big rural development programme.
Unusual manifestations of giant cell arteritis: pulmonary nodules, cough, conjunctivitis and otitis with deafness
Authors: T Zenone, PJ Souquet, C Bohas, D Vital Durand, JP Bernard
Journal: European Respiratory Journal (1994)

The major manifestations of giant cell arteritis have been well described. Pulmonary manifestations, however, are rare. We report the case of a 75 year old woman with temporal arteritis, presenting with atypical manifestations, i.e. nodular pulmonary lesions, dry cough, rhinitis, conjunctivitis, and otitis with hearing loss. We conclude that overlapping features of giant cell arteritis and Wegener's granulomatosis occur in some patients.
Breathing pattern variability: a weaning predictor in postoperative patients recovering from systemic inflammatory response syndrome
Authors: Mauo-Ying Bien, Shu-Shya Hseu, Huey-Wen Yien, Benjamin Ing-Tiau Kuo, Yu-Ting Lin, Jia-Horng Wang, Yu Ru Kou
Journal: Intensive Care Medicine (2004)
The Anatomic Precursor of Colorectal Carcinoma
Authors: Cecilia M. Fenoglio
Journal: JAMA (1975)

IN THIS field, ambiguity in the use of terms is a problem. We hope that we can succeed in presenting a few definitions in a very simple and still accurate manner, as well as some crucial histologic points that have important clinical correlations. To achieve the proper approach to prevention, diagnosis, and therapy of colorectal neoplasms, the pathologist, radiologist, and clinician must speak the same language, with a common understanding and mental image of what these terms mean. Regarding the scope of this commentary, one should recall that the vast majority of colorectal carcinomas are moderately or well-differentiated adenocarcinomas. Our remarks apply only to these carcinomas and not to the rare undifferentiated carcinomas or those carcinomas arising in ulcerative colitis. Similarly, juvenile polyps, inflammatory pseudopolyps, lymphoid masses, leiomyomas, and lipomas may all be "polypoid," but will not be considered. They are neither biologically related nor likely to be confused clinically
Depletion of Cytosolic Phospholipase A2 in Bone Marrow–Derived Macrophages Protects against Lung Cancer Progression and Metastasis
Authors: Mary C.M. Weiser-Evans, Xue-Qing Wang, Jay Amin, Vicki Van Putten, Rashmi Choudhary, Robert A. Winn, Robert Scheinman, Peter Simpson, Mark W. Geraci, Raphael A. Nemenoff
Journal: Cancer Research (2009)

Cancer progression and metastasis involves interactions between tumor cells and the tumor microenvironment (TME). We reported that mice deficient for cytosolic phospholipase A(2) (cPLA(2)-KO) are protected against the development of lung tumors. The goal of this study was to examine the role of cPLA(2) in the TME. Mouse lung cancer cells (CMT167 and Lewis lung carcinoma cells) injected directly into lungs of syngeneic mice formed a primary tumor, and then metastasized to other lobes of the lung and to the mediastinal lymph nodes. Identical cells injected into cPLA(2)-KO mice showed a dramatic decrease in the numbers of secondary metastatic tumors. This was associated with decreased macrophage staining surrounding the tumor. Wild-type mice transplanted with cPLA(2)-KO bone marrow had a marked survival advantage after inoculation with tumor cells compared with mice receiving wild-type (WT) bone marrow. In vitro, coculturing CMT167 cells with bone marrow-derived macrophages from WT mice increased production of interleukin 6 (IL-6) by cancer cells. This increase was blocked in cocultures using cPLA(2)-KO macrophages. Correspondingly, IL-6 staining was decreased in tumors grown in cPLA(2)-KO mice. These data suggest that stromal cPLA(2) plays a critical role in tumor progression by altering tumor-macrophage interactions and cytokine production.
1054-146 Feasibility of focal septal myocardial ablation through the right ventricle using high-intensity focused ultrasound
Authors: Kana Fujikura, Ryo Otsuka, Todd Pulerwitz, Takeki Suzuki, Robert Muratore, Frederic L Lizzi Eng, Shunichi Homma
Journal: Journal of the American College of Cardiology (2004)