tbuckley/cabot-search huggingface dataset:
Decreased aortic compliance aggravates subendocardial ischaemia in dogs with stenosed coronary artery
Authors: H. Watanabe, S. Ohtsuka, M. Kakihana, Y. Sugishita
Journal: Cardiovascular Research (1992)

Journal Article Decreased aortic compliance aggravates subendocardial ischaemia in dogs with stenosed coronary artery Get access Hideki Watanabe, Hideki Watanabe Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305, Japan: H Watanabe, S Ohtsuka, M Kakihana, Y Sugishita. Correspondence to Dr Watanabe. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sadanori Ohtsuka, Sadanori Ohtsuka Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305, Japan: H Watanabe, S Ohtsuka, M Kakihana, Y Sugishita. Search for other works by this author on: Oxford Academic PubMed Google Scholar Masaaki Kakihana, Masaaki Kakihana Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305, Japan: H Watanabe, S Ohtsuka, M Kakihana, Y Sugishita. Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasuro Sugishita Yasuro Sugishita Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305, Japan: H Watanabe, S Ohtsuka, M Kakihana, Y Sugishita. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 12, December 1992, Pages 1212–1218, https://doi.org/10.1093/cvr/26.12.1212 Published: 01 December 1992 Article history Received: 03 March 1992 Accepted: 12 May 1992 Published: 01 December 1992
Epidemiology of sepsis in Germany: results from a national prospective multicenter study
Authors: Christoph Engel, Frank M. Brunkhorst, Hans-Georg Bone, Reinhard Brunkhorst, Herwig Gerlach, Stefan Grond, Matthias Gruendling, Guenter Huhle, Ulrich Jaschinski, Stefan John, Konstantin Mayer, Michael Oppert, Derk Olthoff, Michael Quintel, Max Ragaller, Rolf Rossaint, Frank Stuber, Norbert Weiler, Tobias Welte, Holger Bogatsch, Christiane Hartog, Markus Loeffler, Konrad Reinhart
Journal: Intensive Care Medicine (2007)
Tc-99m Pertechnetate/Sestamibi Imaging in a Case of Recurrent Parathyroid Carcinoma With Metabolic Bone Disorder
Authors: Zhaowei Meng, Jian Tan, Mingfang Zhang, Feng Dong, Qiang Jia, Fuhai Zhang
Journal: Clinical Nuclear Medicine (2009)

A 68-year-old man diagnosed with primary hyperparathyroidism underwent Tc-99m pertechnetate/sestamibi parathyroid imaging. A right-inferior parathyroid hyperfunctioning lesion was revealed. After parathyroidectomy, serum parathormone and calcium dropped to normal levels and parathyroid carcinoma was diagnosed histopathology. The patient did not appear for a regular checkup until 17 months later, when levels of parathormone and calcium rose again. With the same imaging modality, a right-inferior parathyroid hyperfunctioning lesion was detected. Bone scan showed a metabolic bone disorder. After surgery, pathologic diagnosis was confirmed as parathyroid carcinoma again. This case demonstrates parathyroid imaging can be useful for localization of recurrent parathyroid carcinoma, and metabolic bone disorder in a bone scan is also contributive to the diagnosis.
Why Does the Affordable Care Act Remain So Unpopular?
Authors: Gail Wilensky
Journal: JAMA (2015)

In mid-November, just as the second enrollment period for health insurance under the Affordable Care Act (ACA) was starting, a Gallup poll indicated that only 37% of the US public approved of the ACA—a record low percentage (http://bit.ly/1xOiNj8).
Equity-Oriented Monitoring in the Context of Universal Health Coverage
Authors: Ahmad Reza Hosseinpoor, Nicole Bergen, Theadora Koller, Amit Prasad, Anne Schlotheuber, Nicole Valentine, John Lynch, Jeanette Vega
Journal: PLoS Medicine (2014)

As part of the Universal Health Coverage Collection, Ahmad Reza Hosseinpoor and colleagues discuss methodological considerations for equity-oriented monitoring of universal health coverage, and propose recommendations for monitoring and target setting.
Interleukin 2 Therapy for Disseminated Cancer-Reply
Authors: Charles G. Moertel
Journal: JAMA (1987)

<h3>In Reply.—</h3> I find myself largely in agreement with each of the letters above. My editorial was clearly motivated by the overzealous "breakthrough type" media reporting of the high-dose IL-2 experience. This had the major impact on cancer patients, their families, and their physicians described by Rosenfelt et al. I felt it was essential that the severe toxicity and the marginal therapeutic accomplishments of high-dose IL-2 be placed in proper perspective. I seriously doubt that such a realistic appraisal will be damaging to the types of sound clinical research programs described above, particularly since they are directed toward achieving tolerable dosage regimens. My editorial could perhaps be damaging to the commercial offering of high-dose IL-2-LAK cell therapy, but I would have no regrets on that score. Certainly, the lymphokines and cytokines provide a fascinating research area that many cancer centers, including my own, are actively pursuing. Interferon alpha, interferon gamma,
A man with anxiety, confusion, and red eyes
Authors: S. N. Ali, T. Tan, K. Meeran, K. Wynne
Journal: BMJ (2012)

A 31 year old man presented with a four day history of anxiety, insomnia, and confusion. Over the past few months he had intermittently noticed red eyes and a “tummy ache.” A concomitant history from his parents revealed a previous episode of confusion and concern about excessive alcohol intake—he had been drinking 10 units of vodka a day for the past six years. He denied any medical history or current drugs. On examination, he was agitated, tachycardic (heart rate 110 beats/min), and he had bilateral conjunctivitis. Initial investigations showed a calcium concentration of 3.54 mmol/L (reference range 2.15-2.6) and metabolic alkalosis (table⇓). He was treated for acute hypercalcaemia with fluids and discharged when levels normalised. 

View this table:

The patient’s biochemistry results at different time points 



Before further outpatient investigations were performed, he was readmitted two weeks later with confusion and a witnessed seizure. Investigations again showed a raised calcium (3.80 mmol/L), metabolic alkalosis, and new onset acute renal failure (table). Plasma glucose was normal. He was once again treated for acute hypercalcaemia and stabilised. On day three of admission, calcium carbonate tablets were discovered on his bedside table. He reported regularly ingesting up to three packets a day to treat symptoms of indigestion.



### 1 How do you explain this patient’s ocular symptoms?

#### Short answer

Bilateral conjunctivitis is a rare complication of severe hypercalcaemia.

#### Long answer

Although rare, hypercalcaemia can cause ocular complications, …
Natural Killer Cell Inhibitory Receptors Block Actin Cytoskeleton-dependent Recruitment of 2B4 (CD244) to Lipid Rafts
Authors: Carsten Watzl, Eric O. Long
Journal: The Journal of Experimental Medicine (2002)

A dynamic balance of positive and negative signals regulates target cell lysis by natural killer (NK) cells upon engagement of a variety of different activation receptors and of inhibitory receptors that recruit the tyrosine phosphatase SHP-1. However, the step at which activation signals are blocked by SHP-1 is not known. We have been using activation receptor 2B4 (CD244) to study the influence of inhibitory receptors on NK cell activation. Engagement of inhibitory receptors by HLA class I on target cells blocks phosphorylation of 2B4, placing the inhibitory step at the level, or upstream of 2B4 phosphorylation. Here we show that phosphorylated 2B4, after engagement with either antibodies or target cells that express the 2B4 ligand, is found exclusively in a detergent-resistant membrane fraction that contains lipid rafts. Integrity of lipid rafts was essential for phosphorylation and activating function of 2B4. Coengagement of inhibitory receptors blocked 2B4 phosphorylation and 2B4 association with detergent-resistant membranes, indicating that inhibitory receptors function upstream of raft-dependent signals. Recruitment of 2B4 into detergent-resistant membrane fractions and 2B4 phosphorylation were dependent on actin polymerization. Blocking actin cytoskeleton-dependent raft recruitment of different receptors may be a general mechanism by which inhibitory receptors control NK cell activation.
BENIGN CYSTIC EPITHELIOMA.
Authors: JOHN V. SHOEMAKER
Journal: JAMA (1906)

Benign cystic epithelioma has been reported under a variety of titles, all of which were designed to describe, more or less closely, the pathologic changes of the individual case under consideration, or to describe the views held by the individual making the report. Cases of cutaneous epithelium have been described under a variety of captions, and among these titles are to be found hydradenoma, hemangio-endothelioma, syringocystoma, epithelioma adenoid cystium (Brooke<sup>1</sup>), tricho-epithelioma (Jarisch<sup>2</sup>), akanthoma adenoides cystium (Unna) and benign cystic epithelioma (Hartzell<sup>3</sup>). Following the suggestions of these writers, White,<sup>4</sup>Balzer and Ménétrier,<sup>5</sup>Balzer and Grandhomme,<sup>6</sup>Phillippson,<sup>7</sup>Wolters<sup>8</sup>and Hartzell<sup>3</sup>have added examples of this clinically benign form of epithelioma. From the literature<sup>9</sup>we have been able to collect references to but twenty-four reported cases and special articles discussing benign cystic epithelioma. <h3>Patient.</h3> —Miss J. E., aged 22, American, complained of no
The IOC relative energy deficiency in sport clinical assessment tool (RED-S CAT)
Authors: Margo Mountjoy, Jorunn Sundgot-Borgen, Louise Burke, Susan Carter, Naama Constantini, Constance Lebrun, Nanna Meyer, Roberta Sherman, Kathrin Steffen, Richard Budgett, Arne Ljungqvist, Kathryn Ackerman
Journal: British Journal of Sports Medicine (2015)

In April 2014, the International Olympic Committee (IOC) published a Consensus Statement in the British Journal of Sports Medicine (BJSM) entitled “Beyond the Female Athlete Triad – Relative Energy Deficiency in Sport (RED-S)”. To assist sports medicine professionals working in clinical sports medicine with the practical screening and management of the RED-S athlete, the IOC authors have developed a Clinical Assessment Tool – the RED-S CAT .

It is well known that the utility of scientific knowledge is limited at a practical level and that implementing effective interventions in the real life sport setting are challenging. As in all areas of medicine, there is now attention in sports medicine to the growing field of knowledge …
Abstract IA12: Long-term, efficient inhibition of miRNA function in mice using Tough Decoys delivered by Adeno-associated virus vectors
Authors: Phillip D. Zamore
Journal: Cancer Research (2012)

Abstract Understanding the function of individual miRNA species in mice would require the production of hundreds of loss-of-function strains. To accelerate analysis of miRNA biology in mammals, we combined recombinant adeno-associated virus (rAAV) vectors with miRNA ‘Tough Decoys’ (TuDs) to inhibit specific miRNAs. Intravenous injection of rAAV9 expressing anti-miR-122 or anti-let-7 TuD depleted the corresponding miRNA and increased its mRNA targets. rAAV producing anti-miR-122—but not anti-let-7—TuD reduced serum cholesterol by 40% for 18 weeks in wild-type mice. High throughput sequencing of liver miRNAs from the treated mice confirmed that the targeted miRNAs were depleted and revealed that TuD RNAs induce miRNA tailing and trimming in vivo. rAAV-mediated miRNA inhibition thus provides a simple way to study miRNA function in adult mammals and a potential therapy for dyslipidemia and other diseases caused by miRNA deregulation. Citation Format: Phillip D. Zamore. Long-term, efficient inhibition of miRNA function in mice using Tough Decoys delivered by Adeno-associated virus vectors [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer; 2012 Jan 8-11; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(2 Suppl):Abstract nr IA12.
THE RELATIONSHIP BETWEEN GLOMERULAR FILTRATION RATE, PLASMA ASYMMETRIC DIMETHYLARGININE (ADMA) LEVEL AND DEVELOPMENT OF CORONARY COLLATERAL CIRCULATION
Authors: Murat çelik, Atila Iyisoy, Turgay Celik, Mahmut Ilker Yilmaz, Halil Yaman, Ersoy Isik
Journal: Journal of the American College of Cardiology (2010)
Experience with the Björk-Shiley Prosthetic Valve
Authors: DERWARD LEPLEY, CHARLES F. REUBEN, ROBERT J. FLEMMA, JOHN H. HUSTON, JOHN C. MANLEY, JAMES F. HOFFMAN, ALFRED J. TECTOR
Journal: Circulation (1973)

One hundred and eighty-nine patients who had valvular replacement with 213 Björk-Shiley prosthetic heart valves are presented who are 6 months to 2½ years postoperative. Surgical mortality was 2.6% in mitral valve replacement and 8.8% in aortic valve replacement. The late mortality for the entire series was 2.9%. Four patients had episodes of embolization, all from mitral prostheses. Only two incidences of paraprosthetic leaks were noted in patients with mitral valves, and none in patients with valves in the aortic position. The authors believe this prosthesis to be superior in its hemodynamic characteristics and wear durability, with few late complications.
PREVENTING DEATH FROM SHOCK BY ANTIBODY TO ENDOTOXIN CORE GLYCOLIPID
Authors: WilliamA Knaus, R Freeman, F.K Gould, A.C Burden, JeanDaniel Baumgartner, MichelP Glauser, ElisabethJ Ziegler, J.Allen Mccutchan, MelvilleR Klauber
Journal: The Lancet (1985)
Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγnull mice is enhanced by transgenic expression of membrane-bound human SCF
Authors: Michael A. Brehm, Waldemar J. Racki, Jean Leif, Lisa Burzenski, Vishnu Hosur, Amber Wetmore, Bruce Gott, Mary Herlihy, Ronald Ignotz, Raymond Dunn, Leonard D. Shultz, Dale L. Greiner
Journal: Blood (2012)
Effectiveness of programme for reducing cardiovascular risk for men in one general practice.
Authors: R L Gibbins, M Riley, P Brimble
Journal: BMJ (1993)

OBJECTIVES--To assess the effectiveness of a programme for reducing cardiovascular risk in men in terms of clinical measurements and perceptions of patients. DESIGN--Collection of paired data on men attending well person clinics over three to five years. Questionnaire to determine changes in risk related habits. SETTING--Well person clinics in rural general practice with five partners in mid-Wales. SUBJECTS--The first 687 men seen in the clinic: analysable data obtained on 520. Initial age range 28-60 years. MAIN OUTCOME MEASURES--Analysis of serum cholesterol concentration (mmol/l) and blood pressure (mm Hg). Changes in diet, exercise, smoking, and drinking. RESULTS--Mean (SD) cholesterol concentration for all subjects increased from 5.8 (1.0) to 6.0 (1.0), p &lt; 0.001. Overall percentage of ideal weight and mean systolic blood pressure also increased. Mean diastolic blood pressure was unchanged at 84 mm Hg. Professed dietary change, age, and number of visits all had significant effects on final cholesterol concentration. Those seen more often showed a significant decrease in cholesterol concentrations (in those seen more than twice mean (SD) initial value 6.7 (0.9) mmol/l v final value 6.5 (1.0) mmol/l, p &lt; 0.001). Those over 45 years at start of study showed a significant decrease in diastolic blood pressure (mean (SD) initial value 89 (9) mm Hg v final value 86 (7) mm Hg, p &lt; 0.001). CONCLUSIONS--These clinics are not effective in achieving a reduction in mean cholesterol concentration or blood pressure, despite evidence that the message of reduction in risk had been successfully transmitted. Success was achieved in older patients and those in whom a definite problem was identified. Identification of high risk groups and clinical case finding with appropriate long term follow up may be more cost effective in reducing cardiovascular risk than non-specific screening of the whole population.
AN INEXPENSIVE 60-LENS OPHTHALMOSCOPE WITHOUT REKOSS-DISC.
Authors: GEORGE M. GOULD
Journal: JAMA (1898)

It is said that if within five years after graduation an oculist does not devise "A New Ophthalmoscope" his wife and intimate friends begin to make mysterious visits to the best alienists concerning the man's mental condition. I have concluded that it will not do for me to hold out any longer. The little device I show you today is designed to give the working oculist an instrument with double or treble the number of useful lenses in the ordinary ophthalmoscope, without the complicated and bothersome Rekoss-disc, without a handle, that does not need a case, and that is comparatively inexpensive. The lenses are arranged in two sets independent of each other, each set in parallel continuous grooves or channels similar to the Morton instrument in this one respect. Each set of lenses is propelled by a drive-wheel operating a toothed wheel for each of the two sets of lenses,
Colonoscopy. Inefficacy for early carcinoma detection in patients with ulcerative colitis
Authors: T. D. Crowson
Journal: JAMA (1976)

CANCER of the large intestine frequently develops in patients who have had ulcerative colitis for more than ten years. When ulcerative colitis begins in childhood and involves the entire colon, the incidence of colonic cancer after the first ten years is reported to be 20% per decade. With the advent of colonoscopy, it is now suggested that multiple, periodic, colonoscopic biopsies with tissue taken from throughout the colon can detect the early development of cancer<sup>1,2</sup>in patients with chronic ulcerative colitis. The following case report shows that colonoscopy, even in the hands of an excellent endoscopist, cannot always be relied on in the diagnosis of carcinoma. <h3>Report of a Case</h3> A 34-year-old man was first seen at the Ochsner Clinic in 1972. In 1963 a chronic diarrhea that he had had since 1962 had been diagnosed elsewhere as ulcerative colitis. The colitis had been well controlled with salicylazosulfapyridine (Azulfidine);
The Wounded Storyteller: Body, Illness, and Ethics
Authors: Howard Spiro
Journal: JAMA (1996)

In At the Will of the Body: Reflections on Illness , Arthur Frank gave a moving account of his own troubles. Now, in The Wounded Storyteller he writes of the need (obligation, really) for sick persons to tell their stories in order to clarify their own illnesses. For Frank, the wounded healer and the wounded storyteller often turn out to be the same person; the tales of sickness give it meaning and create empathic bonds between the teller and listener (or reader).  A sociologist at the University of Calgary, Frank has survived several diseases, from heart trouble to cancer and more. In that way he has joined what he terms the remission society, people who have been sick and are now well but who can never be completely cured. In this group he includes people in cardiac rehab programs, those recovered from any cancer, people with chronic diseases, and even victims
Decreased High-Density Lipoprotein Cholesterol and Increased Low-Density Cholesterol Levels in Patients with Colorectal Adenomas
Authors: Ekkehard Bayerdorffer
Journal: Annals of Internal Medicine (1993)

Objective: To study the relation between serum lipoprotein levels and the frequency of colorectal adenomas, the benign precursors of colorectal cancer. Design: Cross-sectional. Setting: University hospital in Germany. Patients: The study included 822 of 1124 consecutive patients who underwent colonoscopy at our institution (302 patients were excluded because of malignant disease, chronic inflammatory bowel disease, familial polyposis, partial colectomy, or other chronic diseases). Of the 822 study patients, 194 had colorectal adenoma. Measurements: Serum cholesterol fractions (high-density lipoprotein [HDL], low-density lipoprotein (LDL), and very low-density lipoprotein [VLDL]) and presence or absence of adenomas; univariate and logistic regression analyses were carried out to evaluate the association between serum HDL, LDL, and VLDL cholesterol levels and the frequency of colorectal adenoma. Results: Univariate analysis of the total patient group showed that the HDL cholesterol level was inversely related to the frequency of colorectal adenoma (odds ratio, 0.36; 95% CI, 0.21 to 0.62) and that LDL and VLDL cholesterol levels were positively associated with adenoma frequency (odds ratio, 2.31 [CI, 1.36 to 3.92] and 1.72 [CI, 1.03 to 2.86], respectively). Univariate analysis of the subgroup of 89 patients with high-risk adenomas showed an inverse association between such adenomas and HDL cholesterol (odds ratio, 0.37; CI, 0.18 to 0.76). A logistic regression analysis that included age and body mass index showed an association between lipoprotein levels and the presence of adenomas. The relative strength (in descending order) of these associations was as follows: HDL, LDL, VLDL, and total serum cholesterol. A logistic regression analysis of patients with high-risk adenoma showed a significant association between such adenomas and the HDL cholesterol level. Conclusions: Patients with colorectal adenomas have lower HDL cholesterol levels and higher LDL and VLDL cholesterol levels; these lipoproteins may have prognostic significance for the development of colorectal adenomas.
Discoid Lupus Erythematosus in a Newborn Infant
Authors: Harold C. Epstein, Jerome Z. Litt
Journal: New England Journal of Medicine (1961)

IN 1954 McCuistion and Schoch1 reported the case of a white newborn infant with possible discoid lupus erythematosus. So far as can be determined this is the only previous report of a child born with the clinical and histopathologic signs of lupus erythematosus. Of great interest in this case was the fact that the infant's mother evidenced acute disseminated lupus erythematosus eleven months later. At no time was the infant's L.E.-cell test positive.There have been several references2 3 4 to placental transmission of the L.E. factor in the past few years; the characteristic cells were demonstrated at birth and then disappeared . . .
Drug Interaction: Inhibitory Effect of Neuroleptics on Metabolism of Tricyclic Antidepressants in Man
Authors: L. F. Gram, K. F. Overo
Journal: BMJ (1972)

Total urinary excretion of radioactivity after oral or intravenous administration of a test dose of (14)C-imipramine was measured in eight patients. They were tested before, during, and after treatment with neuroleptics. Excretion diminished while the patients were being treated with perphenazine, haloperidol, or chlorpromazine, though not during flupenthixol treatment.Total urinary excretion of radioactivity and plasma levels of metabolites and unchanged drug were measured in five patients after a test dose of (14)C-nortriptyline. Each patient was tested before and again during perphenazine treatment. In all patients perphenazine treatment caused: (1) decrease of total urinary excretion, (2) decreased plasma level of metabolites, and (3) increased plasma level of unchanged nortriptyline.These results indicate that neuroleptics inhibit the metabolism of tricyclic antidepressants in man.
Intramuscular Oxytocics and Cord Traction in Third Stage of Labour
Authors: D. G. Bonham
Journal: BMJ (1963)

The current management of the third stage of labour is at last, making increasing use of oxytocics in the late second stage and of techniques of cord traction for the delivery of the placenta. The importance of determining the most effective method for the conduct of the third stage by each unit of the maternity services will remain so long as maternal deaths from haemorrhage continue to figure prominently in the Reports on Confidential Enquiries into Maternal Deaths. The slow puerperal recovery of many more patients who, while not in danger of their lives, have blood losses that are larger than necessary, is an important aspect of this subject that does not appear in statistical tables or hospital reports.