tbuckley/cabot-search huggingface dataset:
Relationship of Airway Wall Thickness to Airway Sensitivity and Airway Reactivity in Asthma
Authors: Akio Niimi, Hisako Matsumoto, Masaya Takemura, Tetsuya Ueda, Kazuo Chin, Michiaki Mishima
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Airway wall thickening has been assumed to cause airway hyperresponsiveness, but a protective effect against airway narrowing has also been suggested. We investigated the relationship between airway wall thickness as assessed by helical computed tomography and two components of airway responsiveness, airway sensitivity and reactivity, in patients with stable asthma with (n = 23) and without (n = 22) inhaled steroid treatment. A cross-section of the apical bronchus of the right upper lobe was obtained. Airway wall area corrected by body surface area was measured as an index of wall thickness. Airway sensitivity and reactivity were measured by continuous inhalation of methacholine, on the basis of the methacholine respiratory resistance dose-response curve. The eosinophil count in sputum was determined in 16 patients [steroid (+) group] and 14 patients [steroid (-) group]. In both groups of patients, airway sensitivity was not related to airway reactivity. Airway sensitivity was related to eosinophil count [r = 0.57 in the steroid (+) group and r = 0.49 in the steroid (-) group], but not to airway wall thickness. In contrast, airway reactivity negatively correlated with airway wall thickness [r = -0.56 in the steroid (+) group and r = -0.55 in the steroid (-) group] but not with eosinophil count. Our results suggest that airway wall thickening attenuates airway reactivity in patients with asthma. These findings may have important implications in pathophysiology and in the treatment of airway remodeling.
THE ORIGIN OF CARCINOMA OF THE STOMACH FROM CHRONIC ROUND ULCER OF THE STOMACH.
Authors: G. FUETTERER
Journal: JAMA (1902)

surface of the thigh, buttocks, peri-anal region, axilla, and under surfaces of the breasts in women.When associated with the sharply defined border diagnosis is simple and is rendered more so by the fact that the edge stains mahogany with Lugol's.In other cases, especially on the thigh, there is no distinct border, but more of an irregular, broken line, with outlying patches of various shapes and sizes.It is in these doubtful in- stances that a response to Lugol's shows the similarity of this process to the ordinary eczema marginatum.Though Kaposi, Kobner and Pick have demonstrated the presence of fungi in the epidermic scales, it, is no easy matter to find the trichophyton, and for me the main guide in doubtful instances has been the appear- ance of a deep mahogany stain upon the application of Lugol's solution.Apart from being an aid to diagnosis the solution is an excellent method of treatment.As the condition improves the areas take up the color more faintly and finally not at all.In mycotic eczema, which by its very name signifies a parasitic origin, this test appears to advantage.Des- pite the fact that absolute proof of its parasitic nature is wanting, in its configuration, obstinacy and response to Lugol, it follows the truly parasitic diseases so closely that it is safe to assume that subsequent obser-
Carruthers' marvelous magical mindreading machine
Authors: Charlie Lewis, Jeremy I. M. Carpendale
Journal: Behavioral and Brain Sciences (2009)

Abstract Carruthers presents an interesting analysis of confabulation and a clear attack on introspection. Yet his theory-based alternative is a mechanistic view of “mindreading” which neglects the fact that social understanding occurs within a network of social relationships. In particular, the role of language in his model is too simple.
UK prime minister "guarantees" welfare of residents of struggling nursing home chain
Authors: D. Brindle
Journal: BMJ (2011)

The prime minister’s official spokesman has issued a “guarantee” to safeguard the welfare of 31 000 residents of care homes run by Southern Cross, the biggest private residential and nursing home chain, which is struggling to avoid collapse.

Number 10’s intervention came as controversy over social care fuelled the already heated debate over the government’s planned NHS reforms. In a separate development, there was widespread revulsion at revelations by BBC television’s Panorama programme about the abuse of young adults with learning disabilities at an assessment and treatment unit near Bristol, operated by private company …
Minimally Invasive Aortic Valve Surgery in the Elderly: A Case-Control Study
Authors: Ram Sharony, Eugene A. Grossi, Paul C. Saunders, Charles F. Schwartz, Greg H. Ribakove, Alfred T. Culliford, Patricia Ursomanno, F. Gregory Baumann, Aubrey C. Galloway, Stephen B. Colvin
Journal: Circulation (2003)

Introduction— Although minimally invasive aortic valve surgery (MIAVR) is performed in many centers, few studies have compared its results to a standard sternotomy (SS) approach. We assessed the hypothesis that, when compared with SS in the elderly population, MIAVR has similar morbidity and mortality and allows faster hospital recovery. Methods and Results— From January 1995 through February 2002, 515 patients over age 65 underwent isolated aortic valve replacement. Using data gathered prospectively, 189 MIAVR patients were matched with 189 SS patients by age, ventricular function, valvular pathology, urgency of operation, diabetes, previous cardiac surgery, renal disease, and history of stroke. In each group, 56.1% of patients underwent non-elective procedures, and 28% were ≥80 years old. Hospital mortality (6.9%) and freedom from postoperative morbidity (82.5% versus 81.5%, P =0.79) were similar. Multivariate analysis revealed that urgent procedures [Odds Ratio (OR)=3.97; P =0.03], congestive heart failure (OR=3.94; P =0.03), and ejection fraction &lt;30% (OR=4.16; P =0.03) were significant predictors of hospital mortality. Prolonged length of stay was associated with age ( P =0.05), preoperative stroke (OR=3.5, P =0.001), CHF (OR=2.2, P =0.004), and sternotomy approach (OR=2.3, P =0.002) by multivariate analysis. More MIAVR patients were discharged home (52.6% versus 38.6%, P =0.03) rather than to rehabilitation facilities. Three year actuarial survival revealed no difference between groups. Conclusions— Minimally invasive aortic valve surgery is safe in elderly patients, with morbidity and mortality comparable to sternotomy approach. The shorter hospital stay and greater percentage of patients discharged home after MIAVR reflect enhanced recovery with this technique.
Reduced L-type calcium current in the embryonic chick heart with persistent truncus arteriosus.
Authors: T L Creazzo
Journal: Circulation Research (1990)

Calcium currents were examined in an experimental model in the embryonic chick heart with a congenital malformation known as persistent truncus arteriosus. This is a severe defect characterized by failure of conotruncal and aorticopulmonary septation of the embryonic heart tube. As a result, no separation into the aortic and pulmonary arteries occurs, and there is a common outflow tract. The hearts with persistent truncus arteriosus had a 26% greater ventricular to whole embryo weight, which indicated that the ventricles were enlarged. Both the low-threshold T-type (ICa.T) and the 1,4-dihydropyridine-sensitive L-type (ICa.L) Ca2+ currents were present in the ventricular myocytes from hearts at day 11 of incubation. However, day 11 hearts with persistent truncus arteriosus showed a twofold reduction in the peak magnitude of ICa.L at a test potential of + 10 mV without a concomitant reduction in the number of L channels detected by 1,4-dihydropyridine antagonist [(+)[3H]PN200-110] and agonist (Bay K 8644) receptor binding. The results indicated that an L channel regulatory mechanism other than protein synthesis was affected. These changes are consistent with responses to conditions of excessive hemodynamic burden that have been characterized in adult hearts.
Novel Three-Channel and Three-Slit Stiffening Tube for Total Colonoscopy
Authors: M. Mukai, S. Mukohyama, H. Nakazaki, T. Asahina, H. Makuuchi
Journal: Endoscopy (2002)

Background and Study Aims: Because of the recent marked reduction in the diameter of colonoscopes, existing stiffening tubes require modification of their tips and hardness. The aim of this study was to develop a new stiffening device with a flexible soft tip which closely fitted the colonoscope. It was also designed with three slits, to improve the fit of the stiffening tube itself to the colonoscope and to extend the effective colonoscope length, and equipped with three channels for endoscopic treatment. Materials and Methods: The standard stiffening tube which has been used routinely and a novel three-channel, three-slit (TCTS) stiffening tube were employed alternately (in 160 and 161 patients, respectively). The two tubes were compared for severity of pain experienced by patients, ease of intubation, and complications. Results: Among the 160 patients examined with the standard stiffening tube, one (0.63 %) complained of mild anal pain on intubation and intubation was incomplete in two (1.25 %), because of resistance in the rectum and sigmoid colon. Among the 161 patients examined with the TCTS stiffening tube, three patients who presented early in the series (1.86 %) developed mild proctal redness and erosions, but incomplete intubation or serious complications were not recorded. Conclusion: The TCTS stiffening tube was as easy to use as the standard stiffening tube, and is considered to be both safe and useful.
Cardiologist is sued for comments on potential migraine device
Authors: C. Dyer
Journal: BMJ (2008)

A leading British interventional cardiologist who was a joint principal investigator in a clinical trial of a device made in the United States is being sued for libel and slander in the English courts by the manufacturer. The case concerns comments attributed to him about the trial that were posted on a US based news website for heart specialists.

NMT Medical, which is based in Boston, Massachusetts, makes the STARFlex septal repair implant. The company has launched the legal action against Peter Wilmshurst, a consultant cardiologist at the Royal Shrewsbury Hospital. Dr Wilmshurst and a headache specialist from King’s College London, Andrew Dowson, led the Migraine Intervention with STARFlex Technology (MIST) trial in the United Kingdom to study the effect of the device on migraine ( Circulation 2008;117:1397-404).

The company is suing over an article published in October 2007 by Heartwire, an online cardiology news service (www.theheart.org). Dr Wilmshurst gave an interview to a Heartwire journalist, …
Cervical screening uptake in a dermatology cohort on immunosuppressive agents
Authors: J. Clowry, I. Callanan, K. Eustace, P. Collins, B. Kirby, A. Lally
Journal: British Journal of Dermatology (2014)

Journal Article Cervical screening uptake in a dermatology cohort on immunosuppressive agents Get access J. Clowry, J. Clowry Department of Dermatology St Vincent's University Hospital Elm Park Dublin 4 Ireland Search for other works by this author on: Oxford Academic Google Scholar I. Callanan, I. Callanan Clinical Audit Department St Vincent's University Hospital Elm Park Dublin 4 Ireland Search for other works by this author on: Oxford Academic Google Scholar K. Eustace, K. Eustace Department of Dermatology St Vincent's University Hospital Elm Park Dublin 4 Ireland Search for other works by this author on: Oxford Academic Google Scholar P. Collins, P. Collins Department of Dermatology St Vincent's University Hospital Elm Park Dublin 4 Ireland Search for other works by this author on: Oxford Academic Google Scholar B. Kirby, B. Kirby Department of Dermatology St Vincent's University Hospital Elm Park Dublin 4 Ireland Search for other works by this author on: Oxford Academic Google Scholar A. Lally A. Lally Department of Dermatology St Vincent's University Hospital Elm Park Dublin 4 Ireland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 6, 1 June 2015, Pages 1682–1683, https://doi.org/10.1111/bjd.13609 Published: 01 June 2015
Pellagra: a still existing disease
Authors: J.D. STRATIGOS, A. KATSAMBAS
Journal: British Journal of Dermatology (1977)

Journal Article Pellagra: a still existing disease Get access J.D. STRATIGOS, J.D. STRATIGOS Department of Dermatology, University of Athens School of Medicine, Andreas Syngros Hospital, Athens, Greece Search for other works by this author on: Oxford Academic Google Scholar A. KATSAMBAS A. KATSAMBAS Department of Dermatology, University of Athens School of Medicine, Andreas Syngros Hospital, Athens, Greece Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 96, Issue 1, 1 January 1977, Pages 99–106, https://doi.org/10.1111/j.1365-2133.1977.tb05197.x Published: 01 January 1977
Osteoporosis, Scurvy, and Siderosis in Johannesburg Bantu
Authors: H. C. Seftel, C. Malkin, A. Schmaman, C. Abrahams, S. R. Lynch, R. W. Charlton, T. H. Bothwell
Journal: BMJ (1966)

the treatment of acute leukaemia.Nests of leukaemic cells may remain in the tissues of patients who had been thought to be in a satisfactory state of remission, and treatment must therefore be persisted with until these nests have been eradicated.This should be the ultimate aim (Mathe, 1965).To achieve this it is necessary that on two successive occasions an extensive search must be made for such nests.This search should be followed up by what Dameshek et al. (1965) have called "a new use of old remedies."Clinical trials are now in progress in many American centres on the simultaneous use of several antimitotic agents-as yet, it is too early to judge the results (Freireich and Frei, 1964;Freireich et al., 1964).The clinical procedures that we have adopted in view of our recent results are as follows.The main aim is to induce in our positive cases a state of " true " remission by stepping up the therapeutic dosage which had induced the apparent remission.This concept is based on the hope that the resistance of the nests of leukaemic cells might be due to various extra- cellular factors, such as anatomical site or vascular distribution, rather than intracellular factors.In all cases we use a treat- ment that comprises a two-months course for each type of chemotherapy at maximal doses, alternating with a month's treatment with corticosteroids.This intensive therapy is preceded by a systematic irradiation of the meninges at 1,000 rads.The first course of chemotherapy to be given was methotrexate, which is administered both intrathecally and systemically.The first results that we obtained in the attempt to eradicate the leukaemic cells completely have been encouraging (Mathe, 1965).Full details will be published later. SummaryIn 31 patients with acute leukaemia who were stated to be in " complete remission," as indicated by a normal peripheral blood and bone-marrow, an extensive histological and cytological investigation was carried out.This investigation comprised the counting of blast cells in the circulating blood, examination of bone-marrow from six sites, examination of the cytology of the C.S.F., an electroencephalogram, renal, hepatic, and testicular biopsies, bone-marrow histology, and x-ray examination of the skeleton.Nests of leukaemic cells were found in 12 patients.None of the tests used gave consistently negative results.The lessons to be learnt from this study, as regards both prognosis and the treatment designed to eradicate these leukaemic foci, are discussed.We would like to thank Professors M. Derot, R.
Midsummer madness: x rays and breast cancer
Authors: E. White
Journal: BMJ (1995)

Many women watching ITV's The Big Story last week will doubtless have been alarmed by the claim that three quarters of breast cancers occurring in American women are due to radiation from medical radiography done between 1920 and 1960. The programme was based on a recently published book, Preventing Breast Cancer: The Story of a Major, Proven, Preventable Cause of this Disease by Professor John Gofman of the University of California at Berkeley.

Professor Gofman's claim is founded on the increase in cancers observed in survivors of the Hiroshima atomic bomb. The incidence of breast cancer also …
Death in Myxoedema Coma
Authors: H. S. Le Marquand, W. Hausmann, E. H. Hemsted
Journal: BMJ (1955)

The prevailing opinion appears to be that pericardial effusion is only rarely a contributory factor in causing en- largement of the "myxoedema heart."Kern et al. (1949).describe four consecutive, cases of their own in which an effusion was proved by a pericardial tap and air replace- ment, and they maintain that pericardial effusion is the commonest cause of cardiac enlargement in myxoedema.Cases of myxoedema with dropsy have been recorded by Mussio-Fournier (1925).Mussio-Fournier et al. (1946) have reported one case which also had a pericardial effusion, but they hold that an effusion is a minor factor in the enlarged " myxoedema heart."Bullrich (quoted by Mussio-Fournier et al., 1946) is of the same opinion.The heart diminishes rapidly with adequate doses of thyroid extract unless another form of heart disease is also present.It is evident that there is usually no true hypertrophy, the enlargement being due to a pericardial effusion or perhaps myxoedema of the heart muscle.Coronary atheroma may be present, due to the high blood cholesterol.Digitalis is not indicated.Congestive failure is relatively rare in " myxoedema heart."In my case the heart decreased in size considerably, but it did not return to normal, probably owing to the associated hypertension.There was no evidence that the patient's anasarca was due to hypertensive cardiac failure, in that her symptoms and the oedema were completely relieved by thyroid therapy only, and she was well and without signs of heart failure up to the time of writing.The effusions were due to heart failure caused by the myxoedema.
Sponsored Symposia on Environmental Tobacco Smoke
Authors: Lisa A. Bero
Journal: JAMA (1994)

<h3>Objective.</h3> —To test the hypothesis that symposia on environmental tobacco smoke (ETS) are more likely to present unbalanced data and be authored by tobacco industry—affiliated individuals than journal articles on ETS. To compare the publication records and affiliations of authors of symposia with the authors of scientific consensus documents on ETS. <h3>Design.</h3> —Content analysis of articles; computerized literature searches of English-language publications (except for one symposium) supplemented with additional sources. <h3>Participants (Articles).</h3> —All 297 symposium articles on ETS and a random sample of 100 journal articles on ETS published between January 1, 1965, and March 31,1993; the 1986 Surgeon General's report on ETS; and the 1986 National Research Council's report on ETS. <h3>Main Outcome Measures.</h3> —For each article, regardless of whether it had a methods section, agreement with the tobacco industry position that ETS is not harmful; topic; funding source(s); affiliation(s) of author; and publication records of authors. <h3>Results.</h3> —Of the symposium articles 41% were reviews, compared with 10% of journal articles. A total of 83% of original symposium articles and 100% of journal articles contained methods sections (<i>P</i>=.0001). Symposium articles were more likely to agree with the tobacco industry position (46% vs 20%), less likely to assess the health effects of ETS (22% vs 49%), less likely to disclose their source of funding (22% vs 60%), and more likely to be written by tobacco industry—affiliated authors (35% vs 6%) than journal articles (<i>P</i>=.0001). Symposium authors published a lower proportion of peer-reviewed articles (71% vs 81%) (<i>P</i>=.0001) and were more likely to be affiliated with the tobacco industry (50% vs 0%) than consensus document authors (<i>P</i>=.0004). <h3>Conclusions.</h3> —Symposium articles on ETS differ from journal articles and consensus documents in ways that suggest that symposia are not balanced. (<i>JAMA</i>. 1994;271:612-617)
Fulminating Sonne Dysentery. Report of Two Cases
Authors: R. T. Cooke
Journal: BMJ (1940)

When the radiological evidence of union is considered sufficient to make the possibility of redisplacement unlikely the plaster is removed and the pins extracted.A further skin-tight plaster case is retained until union is complete. SummaryA method of reduction of fractures of the shaft of the tibia is described.It is claimed that the vertical position of the limb above the table allows of good operative access, with ease of radiographic control; that posterior angulation of the fragments due to gravity is eliminated; and that the plaster technique is simplified.
42 A NOVEL VECTORIZED HCV THERAPEUTIC VACCINE (TG4040): RESULTS OF A PHASE I STUDY IN NAIVE PATIENTS CHRONICALLY INFECTED BY HCV
Authors: F. Habersetzer, J.-P. Zarski, V. Leroy, M. Maynard-Muet, J.-P. Bronowicki, C. Feray, C. Hézode, A. Fournillier, C. Bain, G. Inchauspé, G. Honnet, C. Trépo
Journal: Journal of Hepatology (2009)
GW25-e2403 Valsartan attenuates pulmonary arterial hypertension via mitogen-activated protein kinases (MAPKs) signal pathway and Matrix metalloproteinases (MMPs) in rodents
Authors: Lu Yuyan, Guo Haipeng, Li Shuang, Wei Yidong, Chen Wei, Dai Neng, Chen Yingjie, E. Kenneth Weir, Xu Yawei, Xu Dachun
Journal: Journal of the American College of Cardiology (2014)
Evidence that endothelin-1 (ET-1) inhibits insulin-stimulated glucose uptake in rat adipocytes mainly through ETa receptors
Authors: Ying-Chung Lee, Chi-Chang Juan, Victor S. Fang, Yung-Pei Hsu, Shu-Hsia Lin, Ching-Fai Kwok, Low-Tone Ho
Journal: Metabolism (1998)
A PEG-Fmoc conjugate as a nanocarrier for paclitaxel
Authors: Peng Zhang, Yixian Huang, Hao Liu, Rebecca T. Marquez, Jianqin Lu, Wenchen Zhao, Xiaolan Zhang, Xiang Gao, Jiang Li, Raman Venkataramanan, Liang Xu, Song Li
Journal: Biomaterials (2014)