tbuckley/cabot-search huggingface dataset:
A clinical grade cell-based artificial APT, aAPC/mOKT3, for unbiased expansion of CD3+ T lymphocytes
Authors: Valentin Sotov, Toshiki Ochi, Diana Gray, Shlomit Boguslavsky, Vinicius Motta, Naoto Hirano, Marcus Butler
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Recent clinical results confirm that adoptive cell therapy, whereby expanded antitumor lymphocytes are infused into cancer patients, is a promising new therapy. Standardized methods to reproducibly and efficiently expand high quality antitumor lymphocytes in vitro are needed. We
BI-22 * CORRELATION OF MOLECULAR SUBTYPES WITH OVERALL SURVIVAL (OS) IN AVAGLIO, A RANDOMIZED, PLACEBO-CONTROLLED STUDY OF BEVACIZUMAB (BEV) PLUS RADIOTHERAPY (RT) AND TEMOZOLOMIDE (TMZ) FOR NEWLY DIAGNOSED GLIOBLASTOMA (GBM)
Authors: H. Phillips, T. Sandmann, C. Li, T. Cloughesy, O. L. Chinot, W. Wick, R. Nishikawa, W. Mason, R. Henriksson, F. Saran, A. Lai, N. Moore, P. Hegde, L. Abrey, R. Bourgon, J. Garcia, C. Bais
Journal: Neuro-Oncology (2014)

BACKGROUND: Factors that correlate the extent of clinical benefit with anti-VEGF therapy are poorly understood. Two phase 3 trials in newly diagnosed GBM (AVAglio and RTOG-0825) reported that BEV + RT/TMZ prolonged progression-free survival but not OS, versus placebo + RT/TMZ. Specific GBM patient subgroups may derive OS benefit from first-line BEV; tumor profiling has uncovered intrinsic molecular subtypes. BEV efficacy in molecular subtypes was evaluated as an exploratory objective in AVAglio. METHODS: A total of 349 cases from AVAglio (BEV + RT/TMZ, n = 171; placebo + RT/TMZ, n = 178), for which formalin-fixed, paraffin-embedded tissue samples were available for biomarker analysis, were profiled and classified into known GBM molecular subtypes (pre-defined hypothesis, subtypes defined by Verhaak, Cancer Cell 2010 and Phillips, Cancer Cell 2006) using an 800-gene platform. GBM molecular subtypes were correlated with OS. RESULTS: Subtyping by expression of 30 markers described by Phillips (2006) are presented. As observed in recent data from The Cancer Genome Atlas (Brennan, Cell 2013), patients with Proneural isocitrate dehydrogenase 1 (IDH1) wild-type tumors had the worst prognosis among all GBM subtypes. BEV + RT/TMZ conferred a significantly longer OS for patients with Proneural IDH1 wild-type tumors, compared with placebo + RT/TMZ (17.1 vs 12.2 months, HR = 0.42, 95% CI: 0.24-0.72, p = 0.002). Multivariate analysis (accounting for prognostic covariates) revealed an interaction between the Proneural subtype and BEV (p = 0.012). In patients with Mesenchymal or Proliferative tumors, there was no evidence of a difference in OS between the treatment arms. CONCLUSIONS: Candidate molecular predictors were identified in AVAglio; GBM patients with Proneural IDH1 wild-type tumors may derive OS benefit from BEV; these data could impact patient stratification and therapy and give insights into BEV mode of action. The predictive value of the Proneural subtype should be validated in an independent dataset.
ABC of allergies: The epidemiology of allergic disease
Authors: D Jarvis, P Burney
Journal: BMJ (1998)

While presynaptic, protein kinase A (PKA)-dependent, long-term plasticity has been described in numerous brain regions, the target(s) of PKA and the molecular mechanisms leading to sustained changes in neurotransmitter release remain elusive. Here, we acutely reconstitute mossy fiber long-term potentiation (mfLTP) <i>de novo</i> in the mature brains of mutant mice that normally lack this form of plasticity. These results demonstrate that RIM1α, a presynaptic scaffold protein and a potential PKA target, can support mfLTP independent of a role in brain development. Using this approach, we study two mutations of RIM1α (S413A and V415P) and conclude that PKA-phosphorylation-dependent signaling by RIM1α serine 413 is not required for mfLTP, consistent with conclusions reached from the study of RIM1α S413A knockin mice. Together, these results provide insights into the mechanism of mossy fiber LTP and demonstrate a useful acute approach to genetically manipulate mossy fiber synapses in the mature brain.
Obliterative Brachiocephalic Arteritis
Authors: THOMAS B. GIBBONS, ROBERT L. KING
Journal: Circulation (1957)

Although a newcomer to American medical literature, this strange vascular disease of young adult women has been recognized abroad for many years. The etiology is obscure, but the pathologic findings are fairly well documented and the clinical picture is unusually consistent. An obliterative arteritis of the branches of the aortic arch results in severe ocular and cerebral damage. The disease process is relentlessly progressive and the prognosis for sight and life is poor. The present case was treated with corticosteroids and anticoagulants with apparent benefit. This disease should be considered when cataracts are encountered in young people and when arterial pressures and pulses in the upper extremities are absent.
Diagnosis by bronchoalveolar lavage of cause of pulmonary infiltrates in haematological malignancies.
Authors: U Costabel, K J Bross, H Matthys
Journal: BMJ (1985)

Etude de 7 observations. L'etude des cellules provenant du liquide de lavage, et des marqueurs de surface, permet le diagnostic de la cause d'infiltrations pulmonaires chez des malades atteints d'hemopathies malignes, sans presenter les risques des biopsies qui en outre ne sont pas toujours decisives
1043-46 Vulnerable plaque can be the predominant source of serum interleukin-6 but not of serum C-reactive protein in patients with acute myocardial infarction
Authors: Shuichiro Higo, Shinsuke Nanto, Masaaki Uematsu, Tomoki Ohara, Takakazu Morozumi, Jun-ichi Kotani, Masaaki Awata, Toshinari Onishi, Osamu Iida, Noriaki Ito, Seiki Nagata
Journal: Journal of the American College of Cardiology (2004)
Short-term vocational medical work overseas.
Authors: A R Turner, J Turner
Journal: BMJ (1979)

appear to be the failure of parents, health visitors, and some family doctors to appreciate that hyperbilirubinaemia with dark urine is always pathological and requires investigation, and persisting and understandable doubts among some paediatricians about the long- term prognosis in biliary atresia even if satisfactory bile drainage is achieved following portoenterostomy.
857-2 Long-term noninvasive electrophysiologic assessment after repair of total anomalous pulmonary venous connection
Authors: Ronn E Tanel, Stephen M Paridon, Paul M Kirshbom, Diane M Hartman, Nancy B Burnham, Richard F Ittenbach, Thomas L Spray, J William Gaynor
Journal: Journal of the American College of Cardiology (2004)
Extracorporeal Biliary Lithotripsy
Authors: Alan N.G. Barkun
Journal: Annals of Internal Medicine (1990)

Purpose: To identify the technical and physical principles of extracorporeal biliary lithotripsy that are clinically relevant, and to review the patient series published to date. Data Identification: Studies published since 1983 identified through a computerized search of MEDLINE and extensive hand searching of bibliographies in identified articles. Study Selection: Twenty-nine studies done in vitro or in animals and 21 studies in humans assessing biliary lithotripsy. Data Extraction: Based on an understanding of experimental determinants of fragmentation, we assess and explain the differences in the results from the clinical studies. The conclusions concerning overall clinical efficacy and safety are emphasized. Results of Data Analysis: Extracorporeal shock waves will safely fragment the gallstones of 80% to 100% of selected patients. However, the rate of satisfactory fragmentation (defined as the persistence of fragments only 3 to 5 mm in diameter or less) varies widely among the studies (22% to 78%); this discrepancy depends partly on differing characteristics of stone populations. For patients presenting with solitary stones of 20 mm in diameter or less, 90% will be stone-free within 6 to 9 months after lithotripsy; moreover, the success of lithotripsy determines the rapidity and extent of fragment dissolution. Bile-duct-stone lithotripsy is reserved for patients in whom endoscopic stone extraction and intracorporeal lithotripsy, with or without direct contact dissolution, have failed. Lithotripsy achieves ductal clearance in 55% to 85% of patients. Conclusions: Extracorporeal lithotripsy is safe and effective in selected patients, and has a definite role to play in managing patients with biliary stone disease. Its role in the coming years will depend on technical improvements in the generators, a tailored approach to complementary dissolution or extraction, and effective prophylactic therapy for preventing gallstone recurrence.
INCREASED NUMBER OF CIRCULATING ENDOTHELIAL PROGENITORS CELLS ARE ASSOCIATED WITH A HIGHER DEGREE OF COLLATERAL CIRCULATION IN PATIENTS WITH CAD
Authors: Marcos Ibarra, Victor Ocana, Luis Villela, Erasmo De La Pena-Almaguer, Jesus Siller, Enrique Ponce de Leon, Oscar Fajardo, Yolanda Ramos, Jose Borbolla, Guillermo Torre-Amione
Journal: Journal of the American College of Cardiology (2010)
Visceral Pleura Invasion Impact on Non-small Cell Lung Cancer Patient Survival: Its Implications for the Forthcoming TNM Staging Based on a Large-Scale Nation-Wide Database
Authors: Junji Yoshida, Kanji Nagai, Hisao Asamura, Tomoyuki Goya, Yoshihiko Koshiishi, Yasunori Sohara, Kenji Eguchi, Masaki Mori, Yohichi Nakanishi, Ryosuke Tsuchiya, Etsuo Miyaoka
Journal: Journal of Thoracic Oncology (2009)
The Selection and Medical Management of Patients with Mitral Stenosis Treated by Mitral Commissurotomy
Authors: GEORGE C. GRIFFITH, HAROLD MILLER, RICHARD S. COSBY, DAVID C. LEVINSON, SIM P. DIMITROFF, WILLARD J. ZINN, ROBERT W. OBLATH, LAWRENCE M. HERMAN, VARNER J. JOHNS, B. W. MEYER, JOHN C. JONES
Journal: Circulation (1953)

The selection of patients for mitral commissurotomy must be made after considering all manifestations of the rheumatic state. A conservative approach is urged and no patients should be operated upon without evidences of increasing pulmonary hypertension and right heart strain. The preparation of the patient, the management of the arrhythmias during surgery and the postoperative care are the full responsibilities of the physician. A team composed of physiologists, cardiologists and surgeons must work together.
Native type II collagen-induced arthritis in the rat. III. Relationship between the cellular immune response to native type II collagen and arthritis.
Authors: W A Ofosu-Appiah, K Morgan, P J Lennox Holt
Journal: Annals of the Rheumatic Diseases (1983)

The relationship between cell mediated immunity to collagen and arthritis was studied with lymphocytes from arthritic and nonarthritic rats after immunisation with native bovine type II collagen. With the in-vivo radiometric ear assay arthritic rats gave a significantly higher response to native type II collagen than did nonarthritic rats. However, there was an overlap of values, and some arthritic rats gave no response to collagen even on the day of onset of arthritis. There was no difference in the response of lymphocytes from arthritic and nonarthritic rats with in-vitro transformation to native type II collagen, responses being found in both groups. All rats which developed arthritis had serum antibodies to native type II collagen, but not all responded to the tests for cell mediated immunity. These findings suggest that antibodies to collagen are more associated with the development of arthritis than is cell mediated immunity to collagen.
EU health ministers reject proposal for limited direct to consumer advertising
Authors: R. Watson
Journal: BMJ (2003)

Moves to allow drug manufacturers to advertise directly to particular groups of patients have been rejected by European Union health ministers.

The European Commission had proposed relaxing the current ban on direct advertising of prescription drugs almost two years ago as part of a wide ranging reform of existing legislation on drugs. At the time the Commission argued that the initiative would not undermine the overall ban, as it would be subject to stringent conditions and would not constitute direct to consumer …
Bucking the inequality gradient through early child development
Authors: C. Hertzman, A. Siddiqi, E. Hertzman, L. G Irwin, Z. Vaghri, T. A J Houweling, R. Bell, A. Tinajero, M. Marmot
Journal: BMJ (2010)

A good start in life is the key to reducing health and social inequalities in society. <b>Clyde Hertzman and colleagues </b>argue that governments in rich and poor countries should be investing more in programmes to support early child development
Thyrotoxic Periodic Paralysis With Upper Motor Neuron Findings
Authors: Gary Platt, Ronald E. Cranford, David C. Anderson, Jack E. Hubbard
Journal: JAMA (1978)

RECOGNIZED neuromuscular associations of hyperthyroidism include periodic paralysis, thyrotoxic myopathy, myasthenia gravis, and exophthalmic ophthalmoplegia. Periodic paralysis, a common neuromuscular complication of thyrotoxicosis in the Orient, is rare in western countries. The syndrome is characterized by recurring episodes of flaccid weakness of the limbs with depressed or absent deep tendon reflexes. We recently cared for a young white man who had episodic quadriparesis accompanied by definite upper motor neuron findings suggesting a possible spinal cord lesion. Evaluation demonstrated severe hypokalemia as well as hyperthyroidism. Correction of the former resulted in prompt resolution of weakness; upper motor neuron findings persisted until the thyrotoxicosis was controlled. The association of confusional syndromes, coma, seizures, and movement disorders with thyroid hyperactivity implies that the condition affects the CNS. Abnormal upper motor neuron findings also have been described in thyrotoxicosis but are thought to be rare.<sup>1</sup>The simultaneous occurrence of a lower motor neuron complication
Early Post-operative Endoscopy after Biliary Tract Surgery
Authors: N. Soehendra, I. Kempeneers, H.P. Eichfuss, V. Reynders-Frederix
Journal: Endoscopy (1981)

Immediate post-operative complications such as obstructive jaundice, biliary fistulae or gastrointestinal hemorrhage, occurring after biliary tract surgery can be diagnosed endoscopically. The causes of bile flow obstruction and leakage from the common bile duct can be identified using ERC. In many cases the diagnosis can be followed by endoscopic treatment, therefore obviating re-laparotomy. Between 1972 and 1979 we carried out early post-operative ERC or esophago-gastro-duodenoscopy in a total of 94 patients after biliary tract surgery. In 75 patients with residual gallstones and 4 cases with overlooked stenoses of the papilla, successful papillotomies were carried out. The procedure was unsuccessful in one case with an extremely narrow papilla. Complete removal of stones was achieved in 72 cases. In two other patients with gastroduodenal stress ulcers, bleeding was stopped by submucosal infiltration.
Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat.
Authors: X Gu, S P Bishop
Journal: Circulation Research (1994)

Protein kinase C (PKC) activity and isozyme distribution were evaluated during development of pressure-overload-induced cardiac hypertrophy. Three-week-old rats were loosely banded on the ascending aorta (left ventricular hypertrophy [LVH] group). Two weeks later, when left ventricular mass was 50% greater than in the sham-operated control group and cardiac mass was still rapidly increasing beyond that of normal growth, PKC activity and [3H]phorbol 12,13-dibutyrate (PDBu) binding capacity were determined. In LVH, PKC activity was 119 +/- 14%, 158 +/- 17%, and 152 +/- 9% of the control value in cytosol, membrane, and nuclear-cytoskeletal fractions, respectively (n = 9 or 10). [3H]PDBu binding assay revealed increased PKC concentration in LVH cytosolic (control, 0.51 +/- 0.06 pmol/L per milligram; LVH, 0.78 +/- 0.09 pmol/L per milligram; n = 5; P &lt; .05) and membrane fractions (control, 1.33 +/- 0.15; LVH, 2.32 +/- 0.39; n = 5; P &lt; .05). Scatchard analysis indicated no difference in Kd values between control and LVH groups. Immunoblot analysis using PKC isoform-specific antibodies showed that both Ca(2+)-dependent (alpha and beta) and Ca(2+)-independent (delta, epsilon, and zeta) isoforms were present in the left ventricle. Compared with the control value, there was increased concentration in the membrane and nuclear-cytoskeletal fractions for beta 1,2 and epsilon and in the cytosol for beta 1,2. PKC-delta could be detected only in the nuclear-cytoskeletal fraction and was not changed in LVH. PKC-alpha and -zeta were present in all three fractions but were not altered in LVH. These data indicate that PKC activity and concentration increase during development of LVH induced by pressure overload. The increased PKC isozymes were mainly limited to PKC-beta 1,2 and PKC-epsilon, and the increase was present mainly in the membrane and nuclear-cytoskeletal fractions.
Subcutaneous Continuous Glucose Monitoring
Authors: Karsten Jungheim, Klaas-Jan Wientjes, Lutz Heinemann, Volker Lodwig, Theodor Koschinsky, Adelbert J. Schoonen
Journal: Diabetes Care (2001)

Devices for continuous glucose monitoring (1,2) should display the data in real time rather than retrospectively. This is possible by means of the microdialysis technique (3). Therefore, we examined the feasibility of continuous glucose monitoring with functional models of a new microdialysis-based subcutaneous continuous glucose monitoring (SCGM) system (Roche Diagnostics, Mannheim, Germany) for up to 72 h. This system was calibrated by a one-point calibration shortly after the beginning of the recording period.

The SCGM system consists of a microdialysis catheter and a portable extracorporal electrochemical glucose sensor. It displays a new glucose value every minute. The system was tested in 23 ambulatory inpatients with insulin-treated type 1 and type 2 diabetes. For comparison, up to 75 capillary blood glucose samples were taken in each patient. …
Hydroxymethylglutaryl Coenzyme A Reductase Inhibition Reduces <i>Chlamydia pneumoniae</i> -Induced Cell Interaction and Activation
Authors: Ralf Dechend, Jens Gieffers, Rainer Dietz, Achim Joerres, Jan Rupp, Friedrich C. Luft, Matthias Maass
Journal: Circulation (2003)

Chlamydia pneumoniae stimulates chronic inflammation in vascular cells. Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) may have an ameliorating effect. We investigated possible mechanisms.We infected human macrophages that in coculture spread infection to vascular smooth muscle cells (VSMCs). Cerivastatin (250 nmol/L) reduced VSMC infection by 33%. Western blotting made it apparent that VSMC infection resulted in increased cell membrane-associated RhoA and Rac1, implying increased prenylation of these proteins. This effect was blocked by statin but circumvented by mevalonate. Cytochrome C assays showed that infected VSMCs produced increased reactive oxygen species that was blocked by statin. Infection increased nuclear transcription factor-kappaB expression in VSMCs that was dose-dependently suppressed by statin. Infected VSMCs produced and released RANTES and MCP-1. Statin dose-dependently blocked this production both at the mRNA and protein levels. Mevalonate and M geranylgeranylpyrophosphate circumvented these effects.C pneumoniae can be transmitted from macrophages to VSMCs. VSMCs showed an activation profile typical of atherosclerosis, namely Rac1 and RhoA prenylation, nuclear transcription factor-kappaB activation, reactive oxygen species production, and chemokine production. Statin reduces macrophage-mediated C pneumoniae-induced signaling and transmission.
Bladder Neck Obstructions In Children
Authors: David D. Reisman
Journal: JAMA (1964)

Two hundred eighty-five consecutive cases of bladder neck obstruction encountered over a four-year period were reviewed, including difficult cases of bladder neck dysfunction and nonobstructive ureteral reflux. The condition of 90% of the patients was improved and controlled by conservative means, ie, mainly urethral dilations and prolonged medication. Of those with reflux, 50% required surgical intervention. Ureteroplasty should be reserved only for those patients with reflux which is accompanied by uncontrollable infection and dilated ureters, patients in whom obvious ureteral obliquity has been lost. Cineradiography with its visual demonstration of the anatomy and physiology of the urinary tract has solved many perplexing problems and its more widespread use is recommended. In cases of severe renal damage with tortuous, dilated ureters, early uretero-ileal conduit should be performed.
Oesophageal Stenosis after Partial Gastrectomy
Authors: K. C. McKeown
Journal: BMJ (1958)

OESOPHAGEAL STRICTURES AFTER GASTRIC SURGERY BRITJSH 819 can be present and yet be extremely difficult to demonstrate radiologically, the possibility must exist that in many such cases, and perhaps in all, the essential factor is the presence of a hiatus hernia.If anv lesson is to be drawn from these cases it is that when a patient requires gastric aspiration with an indwelling tube he should, if possible, even if there is no reason to suspect the presence of a hiatus hernia, be kept in an up- right position and not lying flat. SummaryFour cases of oesophageal stricture following gastric surgery and naso-gastric intubation are recorded.The oesophagoscopic appearances in these cases were those of reflux oesophagitis, and in each case careful radiological examination demonstrated that a hiatus hernia was present.Reasons are given for believing that, while the recum- bent position and an indwelling gastric tube play a part in producing oesophageal strictures in such cases by initiating or exacerbating reflux oesophagitis, the essen- tial factor is the presence of a hiatus hernia.In all four cases treatment started with regular self- bougienage.This has become unnecessary or virtually unnecessary in two cases.In Case 1 this improvement gradually developed after gastro-enterostomy and vago- tomy performed for persistent duodenal symptoms, and in Case 4 immediately following Collis's operation of gastroplasty.In the other two cases self-bougienage is being continued.It is suggested that when gastric aspiration with an in- dwelling tube is required in any patient the recumbent position should, if possible, be avoided.I thank Mr.
Regimen for Alkalinization of Urine
Authors: Daniel S. J. Choy
Journal: JAMA (1978)

To the Editor.—  In QUESTIONS AND ANSWERS (239:2385, 1978) Donald R. Bennett, MD, PhD, described the recommended daily dosage for a healthy 70-kg adult of sodium bicarbonate taken daily as a urine alkalinizer. He mentioned the usual dosage range of 325 mg to 2 g, one to four times daily, with a maximum total daily dosage of 16 g. He very properly specified great caution with these dosages in patients with edematous sodium-retaining states.  In many years of alkalinizing the urine of patients with lymphoma (in pre-allopurinol days) undergoing lympholytic chemotherapy with attendant hyperuricemia and hyperuricuria, I have successfully followed the dosage plan recommended by Dr Bennett with the exception that acetazolamide, 0.5 to 1.0 g, is prescribed at bedtime. Through inhibition of carbonic anhydrase, this leads to renal secretion of the sodium ion that has been administered during the day, thus achieving sodium balance and alkalinization of the urine