tbuckley/cabot-search huggingface dataset:
Controlled release of avermectin from porous hollow silica nanoparticles: Influence of shell thickness on loading efficiency, UV-shielding property and release
Authors: Zhu-Zhu Li, Shi-Ai Xu, Li-Xiong Wen, Fan Liu, An-Qi Liu, Qing Wang, Hai-Yan Sun, Wen Yu, Jian-Feng Chen
Journal: Journal of Controlled Release (2006)
PRECIPITINS IN THE DIAGNOSIS OF FUNGOUS INFECTIONS*
Authors: R. W. RIDDELL
Journal: British Journal of Dermatology (1961)

Journal Article PRECIPITINS IN THE DIAGNOSIS OF FUNGOUS INFECTIONS Get access R. W. RIDDELL R. W. RIDDELL St. John's Hospital for Diseases of the Skin, Lisle Street, London, W.C.I. and Brompton Hospital, Fulham Road, London, S. W Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 73, Issue 8-9, 1 August 1961, Pages 323–327, https://doi.org/10.1111/j.1365-2133.1961.tb14456.x Published: 01 August 1961
Anion secretion by the inner medullary collecting duct. Evidence for involvement of the cystic fibrosis transmembrane conductance regulator.
Authors: R F Husted, K A Volk, R D Sigmund, J B Stokes
Journal: Journal of Clinical Investigation (1995)

It is well established that the terminal renal collecting duct is capable of electrogenic Na+ absorption. The present experiments examined other active ion transport processes in primary cultures of the rat inner medullary collecting duct. When the amiloride analogue benzamil inhibited electrogenic Na+ absorption, cAMP agonists stimulated a transmonolayer short circuit current that was not dependent on the presence of Na+ in the apical solution, but was dependent on the presence of Cl- and HCO3-. This current was not inhibited by the loop diuretic bumetanide, but was inhibited by ouabain, an inhibitor of the Na+/K+ pump. The current was reduced by anion transport inhibitors, with a profile similar to that seen for inhibitors of the cystic fibrosis transmembrane conductance regulator (CFATR) Cl- channel. Using several PCR strategies, we demonstrated fragments of the predicted lengths and sequence identity with the rat CFTR. Using whole-cell patch-clamp analysis, we demonstrated a cAMP-stimulated Cl- current with characteristics of the CFTR. We conclude that the rat inner medullary collecting duct has the capacity to secrete anions. It is highly likely that the CFTR Cl- channel is involved in this process.
Genetic Variations in TGFβ1, tPA, and ACE and Radiation-Induced Thoracic Toxicities in Patients with Non–Small-Cell Lung Cancer
Authors: Shuanghu (Tiger) Yuan, Vicki L. Ellingrod, Matthew Schipper, Kathleen A. Stringer, Xuwei Cai, James A. Hayman, Jinming Yu, Theodore S. Lawrence, Feng-Ming (Spring) Kong
Journal: Journal of Thoracic Oncology (2012)
Challenge-proven nonsteroidal anti-inflammatory drug hypersensitivity in children
Authors: O. Yilmaz, I. H. Ertoy Karagol, A. Bakirtas, E. Topal, G. E. Celik, M. S. Demirsoy, I. Turktas
Journal: Allergy (2013)

Background Few studies investigated hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) in children. The objective was to determine the frequency of true NSAID hypersensitivity (NSAID-H) and whether there were any parameters in the history of children that would predict NSAID-H. Secondly, an investigation was conducted into whether NSAID-hypersensitive children could tolerate safe alternatives. Differing from previous studies, the researchers followed the recent diagnostic algorithm proposed for acute reactions in NSAID-H. Methods Children with a history suggesting NSAID-H were evaluated by an allergist. The patients with a single NSAID in history were tested first with a skin prick test and if negative challenged with the culprit NSAID. The patients who had reactions with multiple NSAIDs were directly challenged with their culprit drugs. Safe alternatives in children with a confirmed NSAID-H were found by oral provocation tests (OPTs). Results Fifty-eight of 61 patients participated in the study. Thirty-eight patients (65.5%) described a reaction to a single NSAID and 20 mentioned reactions with ≥2 different NSAIDs. Single-drug-induced and cross-reactive NSAID-Hs were proven in 5 of 36 (14%) and 8 of 18 (44%) of patients, respectively. Acetaminophen and nimesulide were tolerated in 60% and 88.8% of the study patients as safe alternatives, respectively. Family history of NSAID-H was found as the only significant predictor of OPT (OR: 5.4; 95% CI: 1.02–28.6). Conclusion Histories of both single and multiple NSAID-Hs are poor predictors of actual drug hypersensitivity. Therefore, diagnostic tests should be performed in all children if no contraindication exits. Family history of NSAID-H is the only significant parameter predicting OPT results.
Assisted suicide organisation opens branch in Germany
Authors: Annette Tuffs
Journal: BMJ (2005)

The decision by Dignitas, the Swiss assisted suicide organisation, to open their first office abroad in Hanover, Lower Saxony, in September this year has provoked fierce controversy in Germany. The branch will provide information and advice to people wanting to commit suicide but will not actually provide any drugs for the purpose, unlike the organisation's head office in Switzerland.

Dignitas was launched in 1998 by former journalist and lawyer Ludwig Minelli, aged 73, and is based in Zurich. It claims to have helped more than 450 terminally ill people to commit suicide, most of them travelling from Germany and other countries to Switzerland where assisted suicide is legal. Active …
Quantitative assessment of ventricular performance in unstable ischemic heart disease by dextran function curves.
Authors: L D Raphael, J A Mantle, R E Moraski, W J Rogers, R O Russell, C E Rackley
Journal: Circulation (1977)

The ability to quantitate the amount of permanent left ventricular dysfunction in patients with unstable ischemic heart disease would have important clinical value. Left ventricular function curves were constructed in sixteen patients with acute myocardial infarctions and five patients with unstable angina pectoris syndrome at an average of 56 hours (+/- 8) after the onset of symptoms. Fifty ml increments of low molecular weight dextran were rapidly infused into the right antrium during constant monitoring of the pulmonary artery end-diastolic pressure (PAEDP) via a Swan-Ganz thermodilution catheter. An average of 400 ml (range 200-800) was infused to produce a significant change in the PAEDP (range 3-13 mm Hg). The cardiac index was measured before and after the dextran infusion. The slope of the left ventricular function curve was calculated by dividing the change in the cardiac index by the change in the PAEDP. The sixteen patients with acute myocardial infarction underwent left heart catheterization and left ventricular biplane angiography an average of six months later. The five patients with unstable angina pectoris were studied within one month. The slope value of the left ventricular function curve was compared angiographic ejection fraction by linear regression analysis and the correlation coefficient was 0.80. These data demonstrate 1) the slope of the left ventricular function curve in patients with acute myocardial infarction or unstable angina correlates well with the angiographically calculated ejection fraction; 2) as early as two days post myocardial infarction, the residual impairment of left ventricular function can be estimated.
Abnormal Scintigraphic Evolution in AA Hepatic Amyloidosis
Authors: F LOMENA, R ROSELL??, F PONS, M GRAU, A GRAC??A, A CATAFAU, J SETOAIN
Journal: Clinical Nuclear Medicine (1988)

A patient with AA amyloidosis secondary to ankylosing spondylitis showed intense liver uptake of Tc-99m MDP on bone imaging. The biopsy showed hepatic amyloid deposition. A repeat bone scan with Tc-99m MDP 1 year later was negative, although the clinical signs and liver function tests of the patient had not changed. A mechanism might exist, other than the affinity of amyloid to calcium, which would explain the extraosseous uptake of pyrophosphates and diphosphonates in organs and soft tissues affected by systemic amyloidosis.
Diagnosis of Bone and Joint Disorders
Authors: Leonard F. Peltier
Journal: JAMA (1988)

The first edition of<i>Diagnosis of Bone and Joint Disorders</i>appeared in 1981 and proved to be a most important work in its field. Eight years later, a new, revised second edition is certainly called for. It is unfortunate that one of the senior authors, Gen Niwayama, died on Jan 4, 1984, of acute lymphoblastic leukemia and could not see the end product of his work and the work of his collaborators. The 37 collaborators have been carefully chosen for their special knowledge, and each makes an important contribution to the work. The six volumes that constitute the work contain 21 sections. Each volume is of a convenient size, which makes the text easy to work with. The text is organized in a consistent manner with initial discussion of technique and methodology, followed by the anatomy, function, and physiology of normal joints. From this point on, individual joint diseases are
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells
Authors: Dan Ran, Wei-Jong Shia, Miao-Chia Lo, Jun-Bao Fan, David A. Knorr, Patrick I. Ferrell, Zhaohui Ye, Ming Yan, Linzhao Cheng, Dan S. Kaufman, Dong-Er Zhang
Journal: Blood (2013)
Vegetarian diet in mild hypertension: a randomised controlled trial.
Authors: B M Margetts, L J Beilin, R Vandongen, B K Armstrong
Journal: BMJ (1986)

In a randomised crossover trial 58 subjects aged 30-64 with mild untreated hypertension were allocated either to a control group eating a typical omnivorous diet or to one of two groups eating an ovolactovegetarian diet for one of two six week periods. A fall in systolic blood pressure of the order of 5 mm Hg occurred during the vegetarian diet periods, with a corresponding rise on resuming a meat diet. The main nutrient changes with the vegetarian diet included an increase in the ratio of polyunsaturated to saturated fats and intake of fibre, calcium, and magnesium and a decrease in the intake of protein and vitamin B12. There were no consistent changes in urinary sodium or potassium excretion or body weight. In untreated subjects with mild hypertension, changing to a vegetarian diet may bring about a worthwhile fall in systolic blood pressure.
Vertebrate genome evolution and the zebrafish gene map
Authors: John H. Postlethwait, Yi-Lin Yan, Michael A. Gates, Sally Horne, Angel Amores, Alison Brownlie, Adriana Donovan, Elizabeth S. Egan, Allan Force, Zhiyuan Gong, Carole Goutel, Andreas Fritz, Robert Kelsh, Ela Knapik, Eric Liao, Barry Paw, David Ransom, Amy Singer, Margaret Thomson, Tariq S. Abduljabbar, Pam Yelick, Dave Beier, J.-S. Joly, Dan Larhammar, Frederic Rosa, Monte Westerfield, Leonard I. Zon, Steve L. Johnson, William S. Talbot
Journal: Nature Genetics (1998)
TCT-245 Impact of Statin Therapy on Plaque Microstructures on Optical Coherence Tomography
Authors: Yu Kataoka, Julie Thornton, Kathy Wolski, Rishi Puri, James Harvey, Kiyoko Uno, Samir Kapadia, E. Murat Tuzcu, Steven Nissen, Stephen Nicholls
Journal: Journal of the American College of Cardiology (2012)
Chemotactic factor inactivators of human granulocytes.
Authors: J P Brozna, R M Senior, D L Kreutzer, P A Ward
Journal: Journal of Clinical Investigation (1977)

During phagocytosis, neutrophils release a variety of substances that include activators and inactivators of chemotactic factors. It is generally considered that these represent hydrolytic enzymes. Elastase and cathepsin G, major proteases released from lysosomal granules during phagocytosis, contain broad hydrolytic activity. This study examined granule elastase and cathepsin G for their role as inactivators of chemotactic factors. Elastase and cathepsin G were purified from human neutrophils by Trasylol-Sepharose and CM-cellulose chromatography. Small amounts (approximately equal to 3 microgram, 1 muM) of elastase and cathepsin G, comparable to quantities released by 10(6) neutrophils during phagocytosis, completely inactivated the C5 chemotactic factor generated in human serum. Larger concentrations were needed to inactivate the C3 chemotactic factor, and when the bacterial chemotactic factor from Escherichia coli was employed, five times more elastase or cathepsin G was ineffective against this chemotactic factor. Supernatant fluid from human neutrophils that had ingested complement-coated zymosan particles contained elastase and cathepsin G and had inactivator activity for both the C5 chemotactic fragment and the bacterial factor. A specific inhibitor of elastase largely abolished the inactivator activity in the phagocytic supernates that was directed against C5 factor but did not affect the inactivator activity for the bacterial factor. Similar results occurred in studies of granule lysates. These data indicate heterogeneity in the chemotactic factor inactivator activity released by phagocytosing neutrophils. The predominant inactivator activity of the C5 chemotactic fragment is attributable to elastase and cathepsin G.
Safety of adjunctive glycoprotein IIb/IIIa blockade during rescue/early percutaneous coronary intervention following full-dose fibrinolytic therapy for acute myocardial infarction
Authors: Matthew T. Roe, Robert P. Giugliano, Robert Tuttle, Vic Hasselblad, Sabina Murphy, Elliott M. Antman, E. Magnus Ohman, Robert A. Harrington, Christopher B. Granger, Kenneth W. Mahaffey, Christopher P. Cannon, A. Michael Lincoff, C. Michael Gibson, Paul W. Armstrong, Frans J. ban de Werf, Robert M. Califf, Eric J. Topol, Eugene Braunwald
Journal: Journal of the American College of Cardiology (2003)
CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype
Authors: Tomohisa Baba, Akihiro Ishizu, Sari Iwasaki, Akira Suzuki, Utano Tomaru, Hitoshi Ikeda, Takashi Yoshiki, Masanori Kasahara
Journal: Blood (2005)
Effects of pico-to-nanometer-thin TiO2 coating on the biological properties of microroughened titanium
Authors: Yoshihiko Sugita, Ken Ishizaki, Fuminori Iwasa, Takeshi Ueno, Hajime Minamikawa, Masahiro Yamada, Takeo Suzuki, Takahiro Ogawa
Journal: Biomaterials (2011)
Meningeal hematopoiesis following radiation myelitis in a hematopoietic stem-cell transplant recipient
Authors: Miwa Sakai, Kazuteru Ohashi, Takeshi Kobayashi, Takuya Yamashita, Hideki Akiyama, Tetuo Nemoto, Shuji Kishida, Noriko Kamata, Hisashi Sakamaki
Journal: American Journal of Hematology (2005)

Extramedullary meningeal hematopoiesis (EMH) represents an uncommon finding after stem-cell transplantation. We describe the case of an allogeneic bone marrow transplantation (BMT) recipient who developed EMH 1 month after radiation myelitis had been diagnosed. A 39-year-old man with multiple myeloma underwent matched unrelated BMT following a myeloablative conditioning regimen of cyclophosphamide and total-body irradiation (200 cGy × 6). This was followed by delivery of 40 Gy of involved-field radiation to an extramedullary plasmacytoma compressing the spinal cord. Although transplantation went extremely well, the patient developed radiation myelitis 7 months after transplantation, and EMH ensued 1 month later. Because the patient was not in a disease state known to cause EMH, it is tempting to speculate that radiation-related neural injuries might cause donor cells to migrate to the central nervous system. Am. J. Hematol. 79:291–293, 2005. © 2005 Wiley-Liss, Inc.
Aspirin Augments IgE-Mediated Histamine Release From Human Peripheral Basophils Via Syk Kinase Activation
Authors: Hiroaki Matsuo, Tomoharu Yokooji, Hironobu Morita, Mina Ooi, Kana Urata, Shunsuke Takahagi, Kaori Ishii, Yuhki Yanase, Takaaki Hiragun, Shoji Mihara, Michihiro Hide
Journal: Journal of Allergy and Clinical Immunology (2013)
Intracellular accumulation of pIgA-R and regulators of transcytotic trafficking in cholestatic rat hepatocytes
Authors: Janet M. Larkin, Hope Coleman, Angelica Espinosa, Amy Levenson, Mee Soon Park, Bonnie Woo, Alice Zervoudakis, Vu Tinh
Journal: Hepatology (2003)

Bile duct ligation (BDL) impairs basolateral-to-apical transcytosis in hepatocytes, causing accumulation of transcytotic carriers for the polymeric IgA receptor (pIgA-R) and redistribution of secretory component (SC) from bile to blood. To gain insight into the mechanisms regulating transcytosis and the pathophysiology of cholestasis, we investigated nascent protein trafficking in control and BDL livers using cell fractionation in the context of in vivo pulse-chase experiments and immunoblot analysis. Control and cholestatic hepatocytes trafficked [35S]-labeled serum proteins and the pIgA-R along the secretory pathway with identical kinetics. However, BDL impaired transcytosis, causing (1) accumulation of the pIgA-R, rab3D, rab11a, and other candidate regulators of apical-directed secretion in a crude vesicle carrier fraction (CVCF) enriched in transcytotic carriers; (2) slow delivery of [35S]-labeled SC to bile; and (3) paracellular reflux of SC from bile to blood. In conclusion, these data indicate that the secretory and transcytotic pathways remain polarized in cholestatic hepatocytes and suggest that the pIgA-R traffics through postendosomal rab3D-, rab11a-, and syntaxin 2-associated compartments, implicating these proteins in the regulation of transcytosis.
Botched circumcisions kill 14 boys in a month
Authors: Pat Sidley
Journal: BMJ (2006)

Doctors' productivity data sent to trusts 116, 219newsroundup0807Trusts throughout England have this week been sent statistics from the Department of Health, which show the most and least productive doctors in five surgical and five medical specialties in their hospital.The data have been compiled by academics at the University of York's department of health sciences.In an article published in this week's Health Service Journal (2006;116(6013): 18-19) researchers point out that, between 2001 and 2005, the basic starting salary for NHS consultants increased by almost 50%."In most industries, employers would expect pay increases to be accompanied by improvements in 'productivity,'" they state."Although this is less usual in public services, the Department of Health must demonstrate to the Treasury and to voters that the new contract has delivered value for money."Charts showing the individual performance of consultants in 10 specialties are being sent to the NHS trust in which they work.They are based on finished consultant episodes, with the output adjusted for case mix.
99mTc MAA Pulmonary Perfusion Scintigraphy in 2 Cases of Anomalous Systemic Arterial Supply to Normal Basal Segments of the Left Lower Lobe of the Lung
Authors: Jie-Hua Xu, Jie Qin, Wei-Zhen Chen, Ju Jiao, Ping Wang, Jian-Fang Li, Yong Zhang, Mu-Hua Cheng
Journal: Clinical Nuclear Medicine (2012)

Reports of 99mTc macroaggregated albumin pulmonary perfusion scintigraphy for anomalous systemic arterial supply to normal basal segments of the left lower lobe of the lung are extremely rare. We performed scintigraphy in 2 patients with the disease to verify their diagnoses and guide the operation as both were initially misdiagnosed. Segmental radiotracer defects in the basal segments of the left lower lobe, which are also characteristic features of pulmonary embolism, were evident in both cases, as expected. Our report provides a complementary noninvasive diagnostic modality of the disease and helps prevent potential misinterpretation of 99mTc macroaggregated albumin scintigraphy.
Diuretics in Hypertension-Reply
Authors: Ray W. Gifford
Journal: JAMA (1961)

<h3>To the Editor:—</h3> As Doctor Goldberger implied in the last paragraph of his communication, the use of thiazide diuretics in the treatment of uncomplicated hypertension in nonedematous patients with good cardiac compensation does not lead to chloride depletion. I have had the opportunity to determine serum levels of sodium, potassium, chloride, and carbon dioxide in at least 100 such patients at intervals during chronic therapy with one of the thiazide diuretics and except for potassium levels, deviations from normal were so infrequent, and when present so insignificant, that I no longer make these determinations routinely. These observations are confirmed by the fact that I have found solution of potassium triplex to be satisfactory replacement therapy when hypopotassemia is present. Furthermore, the enteric-coated tablets of potassium chloride often pass through the gastrointestinal tract intact while the plain tablets are very irritating to the upper gastrointestinal tracts of some patients. I concur
Ethical Issues in Medical Education
Authors: L. Rosenbaum
Journal: JAMA (2004)

STUDENTJAMA provides a forum for critical exchange on current issues in medical education, research, and practice. It is produced by a group of medical student editors in collaboration with the JAMA editorial staff and is published monthly. The content of STUDENTJAMA includes writing by medical students, physicians, and other researchers, as well as original medical student artwork and creative writing. The articles and viewpoints in STUDENTJAMA do not necessarily reflect the opinions of the American Medical Association or of JAMA. All submissions must be the original unpublished work of the author(s). All submitted work is subject to review and editing.
Clinical Predictors of Prolonged Delay in Return of the International Normalized Ratio to within the Therapeutic Range after Excessive Anticoagulation with Warfarin
Authors: Elaine M. Hylek, Susan Regan, Alan S. Go, Robert A. Hughes, Daniel E. Singer, Steven J. Skates
Journal: Annals of Internal Medicine (2001)

Background: An elevated international normalized ratio (INR) increases the risk for major hemorrhage during warfarin therapy. Optimal management of patients with asymptomatic elevations in INR is hampered by the lack of understanding of the time course of INR decay after cessation of warfarin therapy. Objective: To identify predictors of the rate of INR normalization after excessive anticoagulation. Design: Retrospective cohort study. Setting: Outpatient anticoagulant therapy unit. Patients: Outpatients with an INR greater than 6.0 were identified from August 1993 to September 1998. Patients in whom two doses of warfarin were withheld and a follow-up INR was obtained on the second calendar day were enrolled. No patient received vitamin K1. Measurements: The INR was measured 2 days after an INR greater than 6.0 was recorded. Results: Of 633 study patients with an initial INR greater than 6.0, 232 (37%) still had an INR of 4.0 or greater after two doses of warfarin were withheld. Patients who required larger weekly maintenance doses of warfarin were less likely to have an INR of 4.0 or greater on day 2 (adjusted odds ratio per 10 mg of warfarin, 0.87 [95% CI, 0.79 to 0.97]). Other risk factors for having an INR of 4.0 or greater on day 2 included age (odds ratio per decade of life, 1.18 [CI, 1.01 to 1.38]), index INR (odds ratio per unit, 1.25 [CI, 1.14 to 1.37]), decompensated congestive heart failure (odds ratio, 2.79 [CI, 1.30 to 5.98]), and active cancer (odds ratio, 2.48 [CI, 1.11 to 5.57]). Conclusions: Steady-state warfarin dose, advanced age, and extreme elevation in INR are risk factors for prolonged delay in return of the INR to within the therapeutic range. Decompensated congestive heart failure and active cancer greatly increase this risk.