Immunologic Reactions and Hepatitis B Vaccine
Authors: Mark R. Geier, David A. Geier
Journal: Annals of Internal Medicine (2001)

Letters19 June 2001Immunologic Reactions and Hepatitis B VaccineMark R. Geier, MD, PhD and David A. GeierMark R. Geier, MD, PhDThe Genetic Centers of America; Silver Spring, MD 20905 (Mark Geier)Medcon, Inc.; Silver Spring, MD 20905 and David A. GeierThe Genetic Centers of America; Silver Spring, MD 20905 (Mark Geier)Medcon, Inc.; Silver Spring, MD 20905Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-12-200106190-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The medical community has accepted the vaccine for the hepatitis B virus (HBV), a purified, genetically engineered single antigen, as safe. However, reports of immunologic reactions after HBV vaccination exist (1-4). To investigate immunologic reactions associated with the HBV vaccine, we obtained a certified copy of the data from the Vaccine Adverse Events Reporting System (VAERS) database. The data were collected from 1990 through 1997 by the U.S. Centers for Disease Control and Prevention (CDC).We used Microsoft Access (Microsoft Corp., Redmond, Washington) to search for immunologic reactions reported after HBV vaccination. The Table shows the four ...References1. Grotto I, Mandel Y, Ephros M, Ashkenazi I, Shemer J. Major adverse reactions to yeast-derived hepatitis B vaccines—a review. Vaccine. 1998;16:329-34. [PMID: 9607051] CrossrefMedlineGoogle Scholar2. Herroelen L, de Keyser J, Ebinger G. Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine. Lancet. 1991;338:1174-5. [PMID: 1682594] CrossrefMedlineGoogle Scholar3. Nadler JP. Multiple sclerosis and hepatitis B vaccination [Letter]. Clin Infect Dis. 1993;17:928-9. [PMID: 8286645] CrossrefMedlineGoogle Scholar4. Geier MR, Geier DA. Arthritic reactions following hepatitis B vaccination: an analysis of the vaccine adverse events reporting system (VAERS) data from 1990 through 1997. Clin Exp Rheumatol. 2000;18:789-90. [PMID: 11138356] MedlineGoogle Scholar5. Singleton JA, Lloyd JC, Mootrey GT, Salive ME, Chen RT. An overview of the vaccine adverse event reporting system (VAERS) as a surveillance system. VAERS Working Group. Vaccine. 1999;17:2908-17. [PMID: 0010438063] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Mark R. Geier, MD, PhD; David A. GeierAffiliations: The Genetic Centers of America; Silver Spring, MD 20905 (Mark Geier)Medcon, Inc.; Silver Spring, MD 20905 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCutaneous Immunologic Reactions to Hepatitis B Virus Vaccine Francesco Drago and Alfredo Rebora Cutaneous Immunologic Reactions to Hepatitis B Virus Vaccine David A. Geier and Mark R. Geier Metrics Cited byConsequence or coincidence?Autoimmune hazards of hepatitis B vaccineA Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin MimicsTwo case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulareUnderstanding vaccine safety information from the Vaccine Adverse Event Reporting SystemA review of hepatitis B vaccinationCutaneous Immunologic Reactions to Hepatitis B Virus VaccineFrancesco Drago, MD and Alfredo Rebora, MDClinical Implications of Endotoxin Concentrations in VaccinesHepatitis B Vaccination SafetyAn Analysis of the Occurrence of Convulsions and Death After Childhood Vaccination 19 June 2001Volume 134, Issue 12Page: 1155KeywordsAdverse eventsAntigensDatabasesHepatitis BHepatitis B surface antigenHepatitis B virusInfantsVaccines ePublished: 19 June 2001 Issue Published: 19 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...