tbuckley/cabot-search huggingface dataset:
Gray platelet syndrome with splenomegaly and signs of extramedullary hematopoiesis: A case report with review of the literature
Authors: Esa Jantunen, Auli Hänninen, Anita Naukkarinen, Martine Vornanen, Reino Lahtinen
Journal: American Journal of Hematology (1994)

Abstract Gray platelet syndrome (GPS) is a rare bleeding disorder characterized by thrombocytopenia, agranular gray platelets in blood films, and almost total absence of platelet alpha‐granules and their constituents. We describe here a rare case of GPS with myelofibrosis and splenomegaly indicating extramedullary hematopoiesis. Splenectomy was followed by normalization of platelet count but the bleeding diathesis continued. Based on a follow‐up of more than 15 years, the slight myelofibrosis in our patient seems to be non‐progressive. We also summarize the major clinical and laboratory features of previously published cases of GPS in order to obtain more comprehensive understanding of this rare disorder. From the clinical point of view, the bleeding tendency in this syndrome generally varies from mild to moderate, and no specific treatment is usually needed. Careful examination of peripheral blood films is necessary for the diagnosis of this rare syndrome. © 1994 Wiley‐Liss, Inc.
L’accompagnement et l’écoute, bases de la psychothérapie de l’alcoolique
Authors: J. Rainaut
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 L'accompagnement et l'écoute, bases de la psychothérapie de l'alcoolique Subject Area: Psychiatry and Psychology J. Rainaut J. Rainaut Section de Cure et de Rééducation pour Alcooliques, Aix-en-Provence Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 350–351. https://doi.org/10.1159/000287169 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. Rainaut; L'accompagnement et l'écoute, bases de la psychothérapie de l'alcoolique. Psychother Psychosom 31 December 1978; 29 (1-4): 350–351. https://doi.org/10.1159/000287169 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Cryptic cold agglutinin activity of monoclonal macroglobulins
Authors: W. Pruzanski, H. Jacobs, S. Saito, E. M. Donnelly, L. C. Lui
Journal: American Journal of Hematology (1987)

One hundred and twenty sera with monoclonal immunoglobulin M's (IgM's) were tested for cryptic cold agglutinin activity against papain- and neuraminidase-treated adult and cord red blood cells (RBC). Fifteen sera (12.5%) agglutinated papain-treated RBC. Fourteen of these 15 sera also agglutinated neuraminidase-treated RBC. Ten additional sera agglutinated neuraminidase-treated but not papain-treated cells. Three patterns were observed among agglutinators of papain-treated RBC: either predominant agglutination of adult RBC, or of cord RBC or equal reaction, thus resembling I, i and non-Ii patterns of conventional cold agglutinins. We propose to call these patterns, tentatively, Icr (cr for cryptic), icr, and non-Iicr, respectively. Purified monoclonal IgM's retained the above patterns. Eluates from enzyme-treated cells contained monoclonal IgM's. Investigation of neuraminidase-treated RBC has shown that in distinction to T-anti-T system (Thomsen-Friedenreich receptor system), the majority of sera with monoclonal IgM's agglutinated more strongly adult RBC, and some agglutinated more strongly cord RBC. There was no loss of agglutinating activity after repeat freezing and thawing of the sera. Thus, it seems that monoclonal IgM's which react with neuraminidase-treated RBC detect antigenic determinants different from the T antigen. Cryptic CA activity of IgM's should be added to the list of antibody activities of these monoclonal immunoglobulins.
Thyrotropin decreses leptin production in rat adipocytes
Authors: Mitsuyo Shintani, Haruo Nishimura, Takashi Akamizu, Shin Yonemitsu, Hiroaki Masuzaki, Yoshihiro Ogawa, Kiminori Hosoda, Gen Inoue, Yasunao Yoshimasa, Kazuwa Nakao
Journal: Metabolism (1999)
miR-183 in Prostate Cancer Cells Positively Regulates Synthesis and Serum Levels of Prostate-specific Antigen
Authors: Olivia Larne, Päivi Östling, Benedikta S. Haflidadóttir, Zandra Hagman, Anna Aakula, Pekka Kohonen, Olli Kallioniemi, Anders Edsjö, Anders Bjartell, Hans Lilja, Åke Lundwall, Yvonne Ceder
Journal: European Urology (2014)
Membrane Excitation in Cardiac Muscle
Authors: Chandler McC. Brooks, SILVIO WEIDMANN
Journal: Circulation (1961)

The contributions made during the past 10 years are reviewed. Intracellular recording has made it possible to state absolute values for the cardiac resting potential (90 mv., inside negative to outside) and the "overshoot" during activity (30 mv., inside positive to outside). The surface membrane of a resting fiber is considered to be predominately permeable to K ions. During activity, Na conductance increases and K conductance decreases. The latter process is thought to be essential for explaining the high membrane resistance that is measured during the long-lasting "plateau" found with cardiac muscle. A hypothesis is presented that would account for the termination of the plateau and the beginning of repolarization.
Deep-Brain Stimulation — Entering the Era of Human Neural-Network Modulation
Authors: Michael S. Okun
Journal: New England Journal of Medicine (2014)

The research of Alim Benabid and Mahlon DeLong — just recognized with the Lasker–Debakey Clinical Medical Research Award — has led to improved lives for more than 100,000 people with Parkinson's disease or other neurologic or neuropsychiatric disorders.
Understanding the Decline in Coronary Heart Disease Mortality
Authors: Richard J. Havlik
Journal: JAMA (1982)

Over a ten-year period, the United States has experienced a dramatic decline in coronary heart disease mortality, which has resulted in an overall reduction in total mortality and increased life expectancy. In this period between 1968 and 1978, the reduction has been about 25% and has occurred in both sexes, all races, and at all ages. The United States is virtually unique in the world in terms of the magnitude of the decline. Unfortunately, when 1980 age-adjusted rates are compared with 1979 rates, there has been a leveling off of the decline, perhaps as a result of unusually high influenza rates and record-breaking temperatures in many cities.<sup>1</sup>The cause of the decline has been a topic of much speculation. A conference sponsored by the National Heart, Lung, and Blood Institute (NHLBI) in 1978 concluded that both risk-factor reduction and improved medical care contributed to the decline.<sup>2</sup>It has
REACTIVATION OF NON-INFECTIVE VIRUS IN A CORTISONE-INJECTED HOST
Authors: Edwin D. Kilbourne
Journal: The Journal of Experimental Medicine (1955)

The administration of cortisone to chick embryos inoculated with large quantities of inactive influenza B virus results in a rate of viral increase greater than is concommittantly observed with inocula of comparable infectivity which are devoid of inactive particles. Thus, more than a mere negation of autointerference is effected. It is concluded that in the presence of cortisone reactivation has occurred of non-infective virus to a state in which it can participate in viral synthesis. Cortisone-induced viral reactivation is dependent upon a high partide/cell ratio and is thus analogous to the previously described phenomenon of "multiplicity reactivation." Cortisone does not influence either homologous or heterologous viral interference unless reactivation of the inactive interfering virus occurs. Virus reactivable with cortisone possesses both interfering and enzymatic properties. Reactivation of virus with cortisone cannot be effected in vitro but is mediated by the host cell. Two hypotheses concerning the action of cortisone are presented.
Can electrocardiographic screening prevent sudden death in athletes? No
Authors: R. Bahr
Journal: BMJ (2010)

Mandatory electrocardiographic screening of athletes would detect heart problems and save lives, argue <b>Antonio Pelliccia</b> and <b>Domenico Corrado</b> (doi:10.1136/bmj.c4923), but <b>Roald Bahr</b> claims that the diagnostic accuracy is questionable
Environmental Signaling: A Biological Context for Endocrine Disruption
Authors: Ann Oliver Cheek, Peter M. Vonier, Eva Oberdorster, Bridgette Collins Burow, John A. McLachlan
Journal: Environmental Health Perspectives (1998)

Endogenous and exogenous chemical signals have evolved as a means for organisms to respond to physical or biological stimuli in the environment.Sensitivity to these signals can make organisms vulnerable to inadvertent signals from xenobiotics.In this review we discuss how various chemicals can interact with steroidlike signaling pathways, especially estrogen.Numerous compounds have estrogenic activity, including steroids, phytoestrogens, and synthetic chemicals.We compare bioavailability, metabolism, interaction with receptors, and interaction with cell-signaling pathways among these three structurally diverse groups in order to understand how these chemicals influence physiological responses.Based on their mechanisms of action, chemical steroid mimics could plausibly be associated with recent adverse health
Noninvasive coronary angiography by retrospectively electrocardiographically-gated, thin-slice multidetector-array computed tomography
Authors: Dieter Ropers, Ulrich Baum, Karsten Pohle, Katharina Anders, Stefan Ulzheimer, Bernd Ohnesorge, Christian Schlundt, Werner Bautz, Werner G. Daniel, Stephan Achenbach
Journal: Journal of the American College of Cardiology (2003)
Evidence for direct-acting oxidative genotoxicity by reduction products of azo dyes.
Authors: E A Sweeney, J K Chipman, S J Forsythe
Journal: Environmental Health Perspectives (1994)

The intestinal flora forms a complex ecosystem that metabolizes dietary and endogenous nutrients under primarily anaerobic conditions. The ingestion of azo dyes has been proposed as one source of potential genotoxic agents. Many intestinal bacteria are able to reduce the azo bond (termed azofission), which liberates the substituted naphthol compounds. The standard Ames test has not demonstrated mutagenicity either by various common food colorings or by their reduced end products in Salmonella typhimurium strains TA98 and TA100. In contrast, genetic toxicity was demonstrated in the Escherichia coli differential kill assay and in S. typhimurium TA102 for the reduced dyes. The superoxide free radical was produced by the azo dyes only after reduction by the intestinal bacteria Enterococcus faecalis and Bacteroides thetaiotaomicron.
The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development
Authors: C Ragu, S Boukour, G Elain, O Wagner-Ballon, H Raslova, N Debili, E N Olson, D Daegelen, W Vainchenker, O A Bernard, V Penard-Lacronique
Journal: Leukemia (2010)
Treating fissure in ano in outpatients: what dose of local anaesthetic?
Authors: A. C Skinner
Journal: BMJ (1984)

may represent an absence of vascular response to ketanserin at the latter site but could be due to technical problems of using this method to assess circulation in sclerodermatous skin.The results of ketanserin treatment for ulceration in scleroderma appear to be less favourable than the results in treating Raynaud's pheno-
Case 38-1988
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Katherine S. Upchurch, L. Jeffrey Medeiros
Journal: New England Journal of Medicine (1988)

Case Records of the Massachusetts General Hospital from The New England Journal of Medicine — Case 38-1988 — A 58-Year-Old Woman with Fever, Sweats, Congestive Heart Failure, and Lymphadenopathy after Treatment for a Diagnosis of Systemic Lupus Erythematosus
Cyclophosphamide reduces neutrophilic alveolitis in patients with scleroderma lung disease: a retrospective analysis of serial bronchoalveolar lavage investigations
Authors: O Kowal-Bielecka
Journal: Annals of the Rheumatic Diseases (2005)

To determine whether cyclophosphamide is beneficial for patients with scleroderma lung disease (SLD).The effect of 6 months' treatment with intravenous cyclophosphamide on the functional capacity of patients, lung function tests, high resolution computed tomography of the lungs, and cytology of bronchoalveolar lavage was evaluated in 21 patients with SLD.The treatment was well tolerated and all patients completed 6 months' treatment. Intravenous cyclophosphamide stabilised or improved the patients' functional status and lung function tests. The extent of the lungs affected remained unchanged, as assessed with HRCT of the lungs. Patients with SLD and neutrophilic alveolitis (NA) showed greater improvement than patients with normal levels of granulocytes in the bronchoalveolar lavage fluid (BALF). Significant reduction of neutrophils was also seen in the patients with SLD and NA, whereas no significant change was seen in the level of granulocytes in patients with SLD and an initially normal percentage of granulocytes.Previous reports that patients with SLD with increased levels of granulocytes in BALF are more likely to benefit from treatment with intravenous cyclophosphamide are confirmed. Additionally, clinical improvement in this group of patients is accompanied by a significant decrease in the percentage of granulocytes in BALF.
Comparison of 15-year survival for men and women after initial medical or surgical treatment for coronary artery disease: A CASS registry study
Authors: Kathryn B. Davis, Bernard Chaitman, Thomas Ryan, Vera Bittner, J. Ward Kennedy
Journal: Journal of the American College of Cardiology (1995)

This study compared the rates of coronary artery bypass graft surgery and 15-year survival for men and women after initial medical or surgical management.There has been concern that women with coronary artery disease are managed differently than men and that men and women have a different prognosis. The Coronary Artery Surgery Study (CASS) registry is a large data base of well characterized patients with long-term follow-up.Patients underwent cardiac catheterization at 1 of 15 hospitals during 1974 to 1979. Bypass surgery rates were based on 12,452 men and 2,366 women. Survival results were based on 6,018 men and 1,095 women with operable coronary artery disease and initial medical management and 6,922 men and 1,291 women initially managed surgically.At 15 years, bypass surgery rates were 75% for men and 72% for women (p = 0.91). The rates remained similar after adjustment for clinical and angiographic variables. The 15-year survival rate was 50% for men and 49% for women with initial medical treatment (p = 0.53) and 52% for men and 48% for women (p = 0.004) with initial surgical treatment, a difference similar to that for operative mortality (men 2.5%, women 5.3%, p < 0.0001). Survival was improved by bypass surgery in most subgroups, with largest relative risks for high risk patients. Relative risks were similar for men and women.The rate of bypass surgery did not differ between men and women. There were few differences in the survival of men and women. In general, both men and women with initial surgical treatment survived longer, although benefits were clinically and statistically significant only in those at high risk. The benefit was similar in both men and women.
Monitoring treatment response of childhood precursor B-cell acute lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with multiparameter flow cytometry: predictive impact of early blast reduction on the remission status after induction
Authors: R Ratei, G Basso, M Dworzak, G Gaipa, M Veltroni, P Rhein, A Biondi, M Schrappe, W-D Ludwig, L Karawajew
Journal: Leukemia (2008)
Making a Complete Orthopod
Authors: Robert P. Stanton
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Your recent publication "Principles for Graduate Medical Education"<sup>1</sup>was of great interest. Although many of the principles seem to reflect common sense, some are not in current practice. Principle 10, "Education in the broad field of medicine," is specifically a problem within orthopedic surgery. Since the general demise of the "rotating internship," it is clear that the clinical education of physicians entering the field of orthopedic surgery is not consistent with the goal of providing a broad clinical experience prior to specialty education. Obtaining an orthopedic surgery residency is extremely competitive. It is unusual for an individual to be considered highly for a residency spot without some extraordinary qualification. This usually consists of time spent in orthopedic electives in the junior or senior year of medical school. This experience allows the individual to acquire a recommendation from a qualified orthopedic educator. This type of experience is
PREDICTORS OF CARDIAC OUTCOMES BY CMRI IN PATIENTS WITH NONISCHEMIC CARDIOMYOPATHY
Authors: Elliott Elias, Eduardo Pozo, Vijayapraveena Paruchuri, Juan Gaztanaga, Jill Kalman, Jagat Narula, Valentin Fuster, Javier Sanz
Journal: Journal of the American College of Cardiology (2013)
Rational distinctions and adaptations
Authors: D. E. Over, J. St. B. T. Evans
Journal: Behavioral and Brain Sciences (2000)

Stanovich &amp; West (S&amp;W) distinguish between evolutionary rationality and normative rationality, and System 1 and System 2 mental processes. They hold that the main function of System 2 has to do with normative and not evolutionary rationality. We ask how System 2 could then be an adaptation, especially given S&amp;W's own work on individual differences.
Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells
Authors: Kyoungsub Song, Chang Han, Jinqiang Zhang, Dongdong Lu, Srikanta Dash, Mark Feitelson, Kyu Lim, Tong Wu
Journal: Hepatology (2013)

MicroRNA-122 (miR-122), a pivotal liver-specific miRNA, has been implicated in several liver diseases including hepatocellular carcinoma (HCC) and hepatitis C and B viral infection. This study aimed to explore epigenetic regulation of miR-122 in human HCC cells and to examine the effect of hepatitis C virus (HCV) and hepatitis B virus (HBV). We performed microRNA microarray analysis and identified miR-122 as the most up-regulated miRNA (6-fold) in human HCC cells treated with 5′aza-2′deoxycytidine (5-Aza-CdR, DNA methylation inhibitor) and 4-phenylbutyric acid (PBA, histone deacetylation inhibitor). Real-time polymerase chain reaction (PCR) analysis verified significant up-regulation of miR-122 by 5′aza and PBA in HCC cells, and to a lesser extent in primary hepatocytes. Peroxisome proliferator activated receptor-gamma (PPARγ) and retinoid X receptor alpha (RXRα) complex was found to be associated with the DR1 and DR2 consensus site in the miR-122 gene promoter which enhanced miR-122 gene transcription. 5-Aza-CdR and PBA treatment increased the association of PPARγ/RXRα, but decreased the association of its corepressors (N-CoR and SMRT), with the miR-122 DR1 and DR2 motifs. The aforementioned DNA-protein complex also contains SUV39H1, an H3K9 histone methyl transferase, which down-regulates miR-122 expression. Conclusions: These findings establish a novel role of the PPARγ binding complex for epigenetic regulation of miR-122 in human HCC cells. Moreover, we show that hepatitis B virus X protein binds PPARγ and inhibits the transcription of miR-122, whereas hepatitis C viral particles exhibited no significant effect; these findings provide mechanistic insight into reduction of miR-122 in patients with HBV but not with HCV infection. (Hepatology 2013;58:1681–1692)
Relapse of postpolycythemia myelofibrosis after allogeneic stem cell transplantation in a polycythemic phase: successful treatment with donor lymphocyte infusion directed by quantitative PCR test for V617F-JAK2 mutation
Authors: O Benjamini, M Koren-Michowitz, N Amariglio, N Kroger, A Nagler, A Shimoni
Journal: Leukemia (2008)
The Manner of Onset in Acute Rheumatic Fever As Seen in New York City
Authors: HARLOW BROOKS
Journal: Annals of Internal Medicine (1932)

Article1 December 1932The Manner of Onset in Acute Rheumatic Fever As Seen in New York CityHARLOW BROOKS, M.S., M.D., F.A.C.P., CHARLES O'REGAN, B.A., M.D.HARLOW BROOKS, M.S., M.D., F.A.C.P.Search for more papers by this author, CHARLES O'REGAN, B.A., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-6-717 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is universally recognized that rheumatic fever differs materially in its rate of occurrence, in its clinical picture and even in its complications in various parts of the world. Even with very slight variance in geographical distribution, the disease is strikingly modified in many of its most essential respects. Longcope has several times called attention to the fact that the disease as it appears at even so short a distance from New York as Baltimore is very different both in occurrence and in symptomatology. Rare in the tropics, and even in the subtropics, the disease is hardly recognizable to the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York CityFrom the Fourth Medical Service of Bellevue Hospital, and The Nursery and Child's Hospital, New York City. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRheumatic Fever, its Symptoms, Prevention and TreatmentErkrankungen des EndokardRheumatic Fever, its Symptoms, Prevention and TreatmentDie Klinik des rheumatischen FiebersTHE PRESENT STATUS OF THE PROBLEM OF "RHEUMATISM"; A REVIEW OF RECENT AMERICAN AND ENGLISH LITERATURE ON "RHEUMATISM" AND ARTHRITIS*PHILIP S. HENCH, M.D., F.A.C.P., WALTER BAUER, M.D., F.A.C.P., ALMON A. FLETCHER, M.D., DAVID GHRIST, M.D., F.A.C.P., FRANCIS HALL, M.D., F.A.C.P., PRESTON WHITE, M.D. 1 December 1932Volume 6, Issue 6Page: 717-723KeywordsMedical servicesRheumatic fever Issue Published: 1 December 1932 PDF DownloadLoading ...