tbuckley/cabot-search huggingface dataset:
Abstract 320: Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer
Authors: Hiroki Kamino, Yasuyuki Nakamura, Hitoya Sano, Ryuya Murai, Yuri Saito, Manabu Futamura, Kazuhiro Yoshida, Nobuyoshi Hiraoka, Yae Kanai, Ryoji Kushima, Toyomasa Katagiri, Hirofumi Arakawa
Journal: Cancer Research (2014)

Abstract Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria via MALM (Mieap-induced Accumulation of Lysosome-like organelles within Mitochondria) or MIV (Mieap-Induced Vacuole), respectively (1, 2). Two mitochondrial outer membrane proteins, BNIP3 and NIX are essential mediators of MALM (3). Previously, we reported that the Mieap-regulated mitochondrial quality control (MQC) pathway was inactivated in almost 80% of colorectal cancer patients. To evaluate the role of the Mieap-regulated MQC in pancreatic and breast cancer, we analyzed the status of p53, Mieap, BNIP3 and NIX in 50 cases of primary pancreatic cancer and 63 cases of primary breast cancer by examining p53 mutation and Mieap/BNIP3/NIX promoter methylation. As the result, the Mieap-regulated MQC pathway was inactivated in 71% of pancreatic and 27% of breast cancer patients. Interestingly, the BNIP3 promoter methylation was frequently detected in colorectal and pancreatic cancer patients (49% and 58%, respectively) whereas it was not detected in breast cancer patients at all (0%). Instead, the Mieap promoter methylation was highly detected in breast cancer patients (12.7%) compared to colorectal and pancreatic cancer patients (8.8% and 2.0%, respectively). These results suggest that the Mieap-regulated MQC pathway plays a critical role in tumorigenesis of pancreatic and breast cancer, and that there may be some different mechanisms between colorectal/pancreatic and breast cancers for inactivation of the Mieap-regulated MQC pathway. Inactivation of Mieap-regulated MQC pathway leads to the accumulation of unhealthy mitochondria generating high level of mitochondrial reactive oxygen species. We are now investigating whether the p53/Mieap/BNIP3 MQC pathway affects cell growth, cell motility or tumorigenicity using several pancreatic and breast cancer cell lines that are subcutaneously implanted into nude mice. In this paper, we discuss the potential role of the Mieap-regulated MQC in pancreatic and breast tumor suppression. 1. Miyamoto Y et al. PLoS ONE 6: e16054, 2011 2. Kitamura N et al. PLoS ONE 6: e16060, 2011 3. Nakamura Y et al. PLoS ONE 7: e30767, 2012 Citation Format: Hiroki Kamino, Yasuyuki Nakamura, Hitoya Sano, Ryuya Murai, Yuri Saito, Manabu Futamura, Kazuhiro Yoshida, Nobuyoshi Hiraoka, Yae Kanai, Ryoji Kushima, Toyomasa Katagiri, Hirofumi Arakawa. Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 320. doi:10.1158/1538-7445.AM2014-320
A Personal Impression of Dr. Friedmann
Authors: Edwin Walker
Journal: JAMA (1913)

Weakness is (bus very clearly shown when it is compared with 1-s, p. iluiilcxtruels, and yet, according to Lloyd Brothers' advertising literature, 'Specific .Medicines' have ¡ibniil double .the effeet on the system that is possessed by ordinary (non- proprietary?)Iluidextracts.The dose recoi.elided is front V:; to 1 minim every hour, which the writers piiint out is cer¬ tainly not less than that of a pharmacopeia!nuidextract."IOSALINE Report of the Council on Pharmacy and Chemistry Itisaline is a rheumatism remedy for external application.In view of the misleading' ami unwarranted claims which are made for it, the Council voted that Itisaline he refused recog¬ nition and recommended publication of the Committee's report which appears below.W. A. Pdckner, Secretary, committee's reportThe following sweeping but rather indefinite claims are made for losa line."lusaline is a iieiiciriiiiir anil overcomes (he objectionable eschar- otic properties of Iodine; it is readily absorbed ¡nid may bo used wiiiiiiiii discomfort or discoloration.""The strong analgesic properties uf iosaline make n especially useful in controlling pain m cuses uf Neuralgia, Rheumatism, Gout, »inl A i-l litil is Dct'iiriiiuns."As there are few.if any, known iodin compounds which are ''readily absorbed" through the skin and which vvill mil at tlie same time produce discoloration or discomfort, it was thought worth while to take up the examination of Iosaline.Tlie results of this examination are reported by the Chemical Laboratory of the Association as follows:Laboratory Report:-Iosaline is advertised by the Iosaline Company of New York, as a remedy for the treatment by external application, of rheumatism, gout, neuralgia, pneu¬ monia and numerous other diseases.Concerning its compo¬ sition the following statements are made: ",v transparent, Don-staining gelatinold uf combined Iodine with menthol ami methyl Balicylate, "Alcohol UTO. per cent."Chemical icsis de.astrate the preparation in contain 5 per cent, ui' Iodine."
Hours, volume, and type of work of preregistration house officers.
Authors: P J Leslie, J A Williams, C McKenna, G Smith, R C Heading
Journal: BMJ (1990)

To determine the hours, volume, and type of work undertaken by preregistration house officers.Continuous observation of 472 hours of work performed by 12 preregistration house officers based in medical wards, using standard procedures for studying work patterns.A teaching hospital with 340 beds assigned to general medicine and coronary care.12 Of the 16 preregistration house officers in medicine at the hospital.The hours, volume, and type of work undertaken by preregistration house officers in February 1989, as recorded by trained observers on a one to one basis.The hours of duty ranged from 83 to 101 hours each week, the longest period of continuous duty being 58 hours. Each shift, house officers spent up to 25 minutes travelling between wards and an average of 85 minutes treating patients in wards that were cross covered. Between 50% and 71% of house officers' time was spent on patient oriented duties during the day; this fell to between 21% and 53% at night. Each doctor spent an average of 40 minutes filing when off duty after 6 pm.Established procedures for studying workload were effective in monitoring doctors' hours, providing accurate information on the volume and type of work, which is essential to resolve the problems of medical staffing. The study showed that more house officers were needed and that the cross cover system should be stopped. As a result three extra preregistration house officers were appointed.
Pertussis immunisation of children with histories of neurological problems
Authors: D N Baxter
Journal: BMJ (1994)

The reduction in the incidence of whooping cough in Britain since the 1970s is due largely to a more effective national immunisation programme. One factor leading to this improved uptake of vaccine has been the formulation of clearer guidelines for using vaccine.1 Currently, there are three groups of children for whom pertussis immunisation might be deferred until further advice has been obtained: those whose parents or siblings have a history of idiopathic epilepsy; those with a personal history of convulsions; and those who suffered cerebral damage neonatally.

This paper reports on immunisation of children from the above groups, focusing on the occurrence of serious adverse reactions within 28 days of whole cell pertussis vaccine being given (either as single antigen or combined in adsorbed triple vaccine).

The subjects were referred …
Abstract 5304: Serum vascular endothelial growth factor in advanced breast cancer patients might be a key role of inhibitory effect on lymphokine activated killer cells
Authors: Eiji Suzuki, Makiko Hirose, Noriko Suzuki, Mariko Muta, Susumu Sekine, Dai Kitagawa, Kazumi Horiguchi, Tomoyuki Aruga, Toshinari Ymashita, Katsumasa Kuroi
Journal: Cancer Research (2010)

Abstract Previously, we reported that serum from stage IV breast cancer patients diminished the cytotoxic activity of lymphokine activated killer cells (LAKs) (Abstract #4639 AACR in 2008). Thus, we next tested what the critical role for the inhibitory effect on LAKs was. Based on the study of protein detection in the serum using Cytokine Antibody Array (Ray Biotech), serum from stage IV patients seemed to have higher level of vascular endothelial growth factor (VEGF) as compared to early stage patients. To confirm this by more accurate way, we analyzed the serum level of VEGF by using ELISA in 24 breast cancer patients. When the serum level of VEGF was cut off by median (420 pg/ml), 11 patients with higher level of VEGF out of 12 are included in the patients whose serum inhibited the cyototoxic activity of LAKs. Therefore, we hypothesized that VEGF might be one of the key role for inhibitory effect on LAKs and neutralization of serum VEGF from the patients whose serum inhibited the cyototoxic activity of LAKs could have no inhibitory effect on LAKs. Briefly, PBMCs from a healthy volunteer were used as an effector cell for all patients’ serum incubation. After activation of the PBMCs using IL-2, LAKs were prepared and incubated with the individual patient's serum and washed. The LAKs were incubated with human breast cancer cell line MCF-7 as a target cell and LDH assay was performed to detect cytotoxicity of the LAKs. Fourteen out of 24 patients serum (serum 1) showed inhibitory effect on LAKs and we picked up these patients to test blocking study of serum VEGF. Briefly, serum from these 14 patients was incubated with neutralization antibody of VEGF (R16Y, Santa Cruz Biotechnology) (serum 2) before mix with LAKs. After incubation of serum 1 and serum 2 with LAKs, target cell cytotoxicity of LAKs from incubation with serum 1 showed 30-50% reduced level as compared to control LAKs activity. Interestingly, target cell cytotoxicity of all LAKs from incubation with serum 2 did not show such inhibitory effect (mean cell cytotoxicity of LAKs was 33.48% and 57.27%, serum 1 and serum 2, respectively, control; 55.73%). These data suggest that high level of serum VEGF in breast cancer patients might be a key role of inhibitory effect on LAKs and neutralization of the VEGF could help adoptively transferred LAKs as cancer immunotherapy in the patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5304.
The autoimmune regulator (Aire) controls iNKT cell development and maturation
Authors: Qing-Sheng Mi, Zhong-Bin Deng, Sunil K Joshi, Zai-Zhao Wang, Li Zhou, Sarah Eckenrode, Ratanmani Joshi, Dalam Ly, Bing Yi, Terry L Delovitch, Jin-Xiong She
Journal: Nature Medicine (2006)
Points from Letters: Hospital Staff Appointments
Authors: J. W. Ogilvie
Journal: BMJ (1971)

glucose was measured sequentially, blood glucose remained below 20 mg/100 ml for longer than 24 hours.Furthermore, a hypo- glycaemic baby may develop symptoms after many hours of being asymptomatic.This occurred in an infant, seen some years ago, who had a blood glucose level of 15 mg/100 ml at 10 hours of age.He was asymptomatic and was not treated.The glucose level re- mained low until, at 75 hours of age, he had a convulsion which responded to intravenous
Left Atrial Appendage Activity Masquerading as Pulmonary Vein Potentials
Authors: Dipen Shah, Michel Haissaguerre, Pierre Jais, Meleze Hocini, Teiichi Yamane, Laurent Macle, Kee Joon Choi, Jacques Clementy
Journal: Circulation (2002)

Background — Despite extensive proximal ablation, all potentials frequently cannot be eliminated from the left pulmonary veins (PV). Methods and Results — PV electrograms were analyzed during sinus rhythm, coronary sinus, and left atrial appendage (LAA) pacing, and PV and LAA angiography performed. During pacing, an initial low-amplitude slow potential was recorded on the anterior aspect of the left superior PV and anticipated with shortest activation time by LAA pacing. Its timing coincided with posterior LAA activation, shown to be immediately adjacent to the left superior PV by angiography. In the left inferior PV, the first potential was smaller and less sharp, coinciding with adjacent low LA activation. Angiographically, the LAA was at least 15 mm from the left inferior PV. The second sharper potential in both left PVs was eliminated by proximal ablation. Conclusion — Far field LAA activity consistently adds to PV myocardial electrograms in the left superior PV whereas lower, less sharp extravenous potentials in the left inferior PV originate from the inferior LA. They can be identified by LAA and coronary sinus pacing.
Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.
Authors: K Falk, O Rötzschke, K Deres, J Metzger, G Jung, H G Rammensee
Journal: The Journal of Experimental Medicine (1991)

Virus-specific cytotoxic T lymphocytes (CTL) recognize virus-derived peptides presented by major histocompatibility complex (MHC) class I molecules on virus-infected cells. Such peptides have been isolated from infected cells and were compared to synthetic peptides. We found previously the Kd- or Db-restricted natural influenza nucleoprotein peptides to coelute on reversed phase high performance liquid chromatography columns with certain peptidic by-products present in synthetic peptide preparations. Here we show by extensive biochemical and immunological comparison that the natural peptides in all respects behave as the surmised synthetic nonapeptides, and thus, must be identical to them. The absolute amounts of these natural peptides contained in infected cells could be determined to be between 220 and 540 copies by comparing with defined amounts of pure synthetic nonapeptides. The comparison of the natural Kd-restricted peptide with published synthetic peptides known to contain other Kd-restricted CTL epitopes suggested a new MHC allele-specific T cell epitope forecast method, based on the defined length of nine amino acid residues and on critical amino acid residues at the second and the last position.
One-Year Clinical Outcome After Minimally Invasive Direct Coronary Artery Bypass
Authors: Roxana Mehran, George Dangas, Sotiris C. Stamou, Albert J. Pfister, Mercedes K. C. Dullum, Martin B. Leon, Paul J. Corso
Journal: Circulation (2000)

Minimally invasive coronary artery bypass (MIDCAB) is a new surgical technique by which the left internal mammary artery is anastomosed under direct visualization to the left anterior descending artery without cardiopulmonary bypass.We followed all 274 patients who underwent MIDCAB from the time it was introduced at a single center. In-hospital and 1-year clinical events were source-documented and adjudicated. The in-hospital major acute cardiac event rate was 2.2%; this included a 1.1% mortality rate. At 1 year, the respective rates were 7.8% and 2. 5%. When compared with the initial 100 procedures, the subsequent 174 procedures had shorter vessel occlusion times (10+/-5 versus 14+/-6 minutes; P:=0.009), times to extubation (6+/-3 versus 14+/-10 hours; P:<0.001), and lengths of hospital stay (2.1+/-1.9 versus 3. 2+/-3.1 days; P:=0.04). Cumulative 1-year adverse cardiac events were 11% in the initial 100 cases and 6% in the subsequent 174 cases (P:=0.17).Excellent clinical results can be achieved with the MIDCAB technique. The clinical adverse event rate may decrease with accumulated experience.
MULTISITE LEFT VENTRICULAR PACING IMPROVES ACUTE MECHANICAL DYSSYNCHRONY IN HEART FAILURE PATIENTS
Authors: C. Aldo Rinaldi, Wolfgang Kranig, Christophe Leclercq, Salem Kacet, Tim Betts, Pierre Bordachar, Klaus Gutleben, Allen Keel, Kyungmoo Ryu, Taraneh G. Farazi, Marcus Simon, Tasneem Naqvi
Journal: Journal of the American College of Cardiology (2012)
CONTROLLED CLINICAL TRIAL OF COMPLETE OPEN SURGICAL DRAINAGE AND OF PREDNISOLONE IN TREATMENT OF TUBERCULOUS PERICARDIAL EFFUSION IN TRANSKEI
Authors: J.I.G. Strang, D.G. Gibson, D.A. Mitchison, D.J. Girling, H.H.S. Kakaza, B.W. Allen, D.J. Evans, A.J. Nunn, W. Fox
Journal: The Lancet (1988)
Action of FPL 52694 on gastric acid secretion in the healthy human stomach.
Authors: H J Reimann, U Schmidt, B Ultsch, T J Sullivan, P Wendt
Journal: Gut (1984)

In a double blind crossover experiment in 16 healthy male volunteers, the effects of oral FPL 52694 and a matching placebo upon pentagastrin stimulated gastric acid secretion, gastric mucosal histamine content, and gastric mucosal mast cell count were compared. There was a significant increase in acid secretion, and a fall in tissue histamine and the mast cell count after treatment with the placebo. All these changes were inhibited by FPL 52694, and there was a significant difference between the effects of this compound and the placebo in all three parameters. It is concluded that FPL 52694 caused significant inhibition of acid secretion, and that the likely mechanism of action is by stabilisation of mast cells and inhibition of histamine release.
Pravastatin improves renal ischemia–reperfusion injury by inhibiting the mevalonate pathway
Authors: Satoru Sharyo, Naoko Yokota-Ikeda, Miyuki Mori, Kazuyoshi Kumagai, Kazuyuki Uchida, Katsuaki Ito, Melissa J. Burne-Taney, Hamid Rabb, Masahiro Ikeda
Journal: Kidney International (2008)
AMINOGLUTETHIMIDE IN TREATMENT OF METASTATIC BREAST CARCINOMA
Authors: I.E. Smith, B.M. Fitzharris, J.A. Mckinna, D.R. Fahmy, A.G. Nash, A.M. Neville, J.-C. Gazet, H.T. Ford, T.J. Powles
Journal: The Lancet (1978)
New Human Embryonic Stem-Cell Lines — More Is Better
Authors: John Gearhart
Journal: New England Journal of Medicine (2004)

It is rare that a field of scientific research can simultaneously represent a domain of fundamental discovery in human biology and potentially have major effects on human health and the quality of life. Human embryonic stem cells serve not only as a resource for basic research, but also as the starting material for the development of cell-based therapies. Formidable scientific challenges face those who aim to develop cell-based therapies. It will take the efforts of many scientists and clinicians in a variety of disciplines to bring this endeavor to fruition. Of immediate importance and concern is whether or not we . . .
DIETARY HEALING OF DENTAL CARIES
Authors: S. S. Arnim
Journal: JAMA (1941)

<h3>To the Editor:—</h3> In the September 27 issue, page 1099, appears an editorial entitled "Dietary Healing of Dental Caries." The opinions clearly reveal that some one has disseminated misleading interpretations of a physiologic process previously described. A careful reading of Sognnaes' paper in<i>Science</i>reveals a tendency on the part of the author to wishful thinking when he applies the term reparative process to what is obviously the deposition of secondary dentin. The person who wrote the editorial certainly went Sognnaes one better with his statement that secondary dentin more or less filled the earlier cavity. Secondary dentin forms in all rats' teeth subject to wear and frequently in rats' teeth that are not subject to wear, regardless of the presence or absence of dental caries. Hoffman and Schour (<i>Am. J. Orthodontics</i><b>26</b>:854 [Sept.] 1940) have described this process in mathematically exact terms. Their work, coupled with mine, explain
Home oxygen therapy during natural disasters: lessons from the great East Japan earthquake: Figure 1–
Authors: S. Kobayashi, M. Hanagama, S. Yamanda, M. Yanai
Journal: European Respiratory Journal (2012)

To the Editors:

Oxygen therapy is given to patients with hypoxaemia caused by diseases such as chronic obstructive pulmonary disease, interstitial lung disease and cystic fibrosis [1]. In cases of natural disasters, patients receiving oxygen therapy in their homes can lose their stable oxygen supply for long periods of time due to power failure or equipment damage. Little has been established for the management of these patients during disasters. On March 11, 2011, a 9.0-magnitude earthquake and subsequent tsunami struck large parts of the east coast of Japan. Over 20,000 people died or were listed as missing following this disaster [2]. Here, we discuss the problems, based on our experience, in the management of patients receiving home oxygen therapy during disasters.

Avoiding treatment interruption during a disaster is essential in maintaining disease stabilisation for patients receiving oxygen therapy. In Japan, home oxygen therapy is widely used for patients with chronic respiratory failure and covered by the national healthcare insurance system …
Pulmonary alveolar microlithiasis: review of Turkish reports.
Authors: E S Ucan, A I Keyf, R Aydilek, Z Yalcin, S Sebit, M Kudu, U Ok
Journal: Thorax (1993)

Pulmonary alveolar microlithiasis is a rare disorder, only 173 cases having been reported worldwide. Fifty two cases from Turkey are reported, 49 of which have previously been described only in Turkish publications. The mean age of the patients was 27 (SD 12) years, 34 were male, and 10 were symptomless. In 40 of the 52 cases diagnosis was confirmed histopathologically. Nineteen cases were diagnosed in siblings. This high rate suggests that pulmonary alveolar microlithiasis is a familial disease, which, though rare, is for unknown reasons most common in Turkey.
Tuberculin responses in children with allergic diseases
Authors: S. Ozmen, N. Tomac, A. Uysal, Z. Arslan, N. Kuyucu, A. Yoney
Journal: Allergy (2002)

Background: The prevalence of allergic disorders has been increasing over the last 30 years, especially in developed countries. One factor associated with this rise may be the decline of many childhood infections. We investigated tuberculin responses in allergic children in order to see the development of delayed‐type hypersensitivity reactions to tubercule bacillus infection. Methods: The study sample was composed of 106 allergic and 100 nonallergic children vaccinated with bacille Calmette‐Guerin (BCG). The standard Mantoux test was applied to all children. The reactions were read after 72 h by measuring the diameter of the wheal. Results: The wheal size was 6.29 ± 5.09 mm (mean ± SD) in allergic children, and 2.79 ± 2.96 mm in nonallergic children. The difference between the two groups was significant ( P &lt; 0.001). In children with a single BCG scar, the mean purified protein derivative (PPD) wheal size for allergic children was 4.77 ± 4.79 mm, and for nonallergic children it was 2.48 ± 3.19 mm. The mean PPD wheal sizes in allergic and nonallergic children who had been vaccinated twice were 8.35 ± 4.80 mm and 3.33 ± 2.44 mm, respectively. This difference was statistically significant ( P &lt; 0.05). In 27.35% of the allergic children and 6% of the nonallergic children, the positive tuberculin responses (PPD ≥ 10 mm) were recorded. The difference was significant ( P &lt; 0.05). Conclusions: Our results showed that response to tuberculin in BCG‐immunized allergic children is higher than in BCG‐immunized nonallergic children.
Emerging concepts in immunity to hepatitis C virus infection
Authors: Hugo R. Rosen
Journal: Journal of Clinical Investigation (2013)

Since the discovery of hepatitis C virus (HCV) by molecular cloning almost a quarter of a century ago, unprecedented at the time because the virus had never been grown in cell culture or detected serologically, there have been impressive strides in many facets of our understanding of the natural history of the disease, the viral life cycle, the pathogenesis, and antiviral therapy. It is apparent that the virus has developed multiple strategies to evade immune surveillance and eradication. This Review covers what we currently understand of the temporal and spatial immunological changes within the human innate and adaptive host immune responses that ultimately determine the outcomes of HCV infection.