tbuckley/cabot-search huggingface dataset:
Maurice Ravel and Alzheimer's Disease
Authors: Stanley F. Wainapel
Journal: JAMA (1985)

To the Editor.—  Dalessio's 1 recent editorial about Maurice Ravel effectively portrays the tragic final years of that influential 20th-century composer. However, I must take exception to his description of Ravel's amusia. I base these comments on the published testimony of Ravel's neurologist, Theophile Alajouanine, whose article, Aphasia and Artistic Realization, 2 should be read by any physician with an interest in the creative arts.  Assisted by one of Ravel's favored pupils and by a neurology colleague who was also an accomplished musician, Alajouanine made a detailed study of his celebrated patient's musical abilities. What he found was that Ravel's capacity to appreciate music and evaluate it critically was unimpaired. For example, when some of his own piano music was played for him with even minor errors in rhythm or melody, he could immediately identify the errors, and, in his halting speech, he could specify what was incorrect. Also, his
Unusual case of anaemia.
Authors: I. G. McGill
Journal: BMJ (1968)

Cbase 1.-A girl aged 20 developed facial twitching and sustained oculogyric crises after perphenazine 5 mg.In view of the known value of chlorpromazine in post-encephalitic oculogyric crises this drug wNas given empirically.Within minutes of receivina an intramuscular injection of chlorpromazine 25 mg. the oculogyric crisis and the muscle twitching ceased.Case 2.-A woman aged 38 developed her second dystonic reaction to trifluoperazine, approximately 5 mg. in dosage.The first reaction five years previously was diagnosed as hysteria.She showed facial twitching, trismus, and torti- collis.The reaction steadily worsened over eight hours, but within 10 minutes of intramuscular injection of chlorpromazine 25 mg.ceased entirely and did not recur.Case 3.-A girl aged 21 developed jerking of the limbs, twitching of the facial muscles, and retrocollic movements of the head.This followed 90 mg. of metoclopramide (Maxolon).Bcnztropine methanesulphonate 10 mg. was given intramuscularly with no effect over a two- hour period of observation.Chlorpromazine 25 mg.was given by intramuscular injection, and within minutes the reaction virtually ceased.In this case the movements recurred every three hours and over the next 48 hours this quick and predictable response to chlorpromazine was repeatedly confirmed, until the reaction finally ceased.
Validated, Electronic Health Record Deployable Prediction Models for Assessing Patient Risk of 30-Day Rehospitalization and Mortality in Older Heart Failure Patients
Authors: Zubin J. Eapen, Li Liang, Gregg C. Fonarow, Paul A. Heidenreich, Lesley H. Curtis, Eric D. Peterson, Adrian F. Hernandez
Journal: JACC Heart Failure (2013)
Modified Serum Profiles of Inflammatory and Vasoconstrictive Factors in Patients With Emotional Stress-Induced Acute Coronary Syndrome During World Cup Soccer 2006
Authors: Ute Wilbert-Lampen, Thomas Nickel, David Leistner, Denise Güthlin, Tomas Matis, Christoph Völker, Sebastian Sper, Helmut Küchenhoff, Stefan Kääb, Gerhard Steinbeck
Journal: Journal of the American College of Cardiology (2010)
Side effects of tamoxifen are distressing and common
Authors: A. Ray, R. C F Leonard
Journal: BMJ (1996)

different, probably because of the way the schemes were applied.It is difficult to know how many of the practices participated actively in the Northern region's scheme because entry to the scheme was automatic; the uptake in Lothian was 75%.Table 1 shows the proportion of prac- tices in both regions that achieved their financial target and the proportions in Lothian that achieved the target for generic prescribing and the quality target.The quality target produced 33 audits of prescribing and 12 quality standards for prescribing at practice level.The disadvantage of applying Lothian's scheme is that it is time consuming for both practices and prescribing advisers, but the results suggest that tailoring a scheme to individual practices is an effective strategy.
Effect of hydrocortisone butyrate on collagen synthesis
Authors: HEIKKI SAARNI, VAINO K. HOPSU-HAVU
Journal: British Journal of Dermatology (1976)

Journal Article Effect of hydrocortisone butyrate on collagen synthesis Get access HEIKKI SAARNI, HEIKKI SAARNI Departments of Medical Chemistry and Dermatology, University of Turku, 20520 Turku 52, Finland Search for other works by this author on: Oxford Academic Google Scholar VÄINÖ K. HOPSU‐HAVU VÄINÖ K. HOPSU‐HAVU Departments of Medical Chemistry and Dermatology, University of Turku, 20520 Turku 52, Finland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 95, Issue 5, 1 November 1976, Pages 566–567, https://doi.org/10.1111/j.1365-2133.1976.tb00872.x Published: 01 November 1976
Lyso-PAF acetyltransferase activity in neutrophils of patients during acute asthma and after recovery
Authors: NL Misso, RL Gillon, GA Stewart, PJ Thompson
Journal: European Respiratory Journal (1996)

The production of platelet-activating factor (PAF) by inflammatory cells is regulated by lyso-PAF acetyltransferase, and the activity of this enzyme is increased in neutrophils of stable asthmatic patients. The aim of this investigation was to determine whether acetyltransferase activity is further upregulated in asthmatic patients experiencing acute symptoms. A radioenzymatic assay was used to measure the enzymatic affinity constant (Km) and maximal enzymatic activity (Vmax) for acetyltransferase from unstimulated and Ca2+ ionophore (A23187)-stimulated neutrophils from 16 patients with acute asthma, and the measurement was repeated at the time of discharge (n=9) and after recovery from the acute episode (n=13). During acute asthma, Km (median 93.8 (interquartile range 64.1-109.7) microM) was lower than that measured in nonasthmatic subjects in a previous study using identical methods (155.1 (122.2-179.9) microM; p=0.0001), and in 10 out of 13 acute patients Km for unstimulated neutrophils increased following recovery. In A23187-stimulated neutrophils, Km during acute asthma (84.3 (73.6-100.2) microM) and at discharge (83.9 (83.1-94.8) microM) were similar, but Km after recovery was increased (115.0 (95.6-119.5) microM; p=0.02). The change in Km following stimulation with A23187 was also significantly less during acute asthma than previously measured in nonasthmatic subjects (p=0.003). Although Vmax during acute asthma (12.9 (interquartile range 10.5-22.5) nmol x min(-1) x mg(-1) protein) did not differ significantly from that at discharge (14.4 (12.3-20.4) nmol x min(-1) x mg(-1)) or after recovery (17.3 (12.3-18.4) nmol x min(-1) x mg(-1)), both median Km and Vmax tended to be lowest during acute asthma and increase at discharge and after recovery. An increase in lyso-PAF acetyltransferase activity alone may not account for increased systemic PAF concentrations during acute asthma. However, the reduction in the enzymatic affinity constant and its smaller change following in vitro stimulation suggest that alterations in the affinity of acetyltransferase for acetylcoenzyme A (CoA) and in the regulation of enzyme activity may be occurring during acute asthma.
Relationship of low-density lipoprotein particle size to insulin resistance and intima-media thickness in nondiabetic Koreans
Authors: Jong Suk Park, Jina Park, Chul Sik Kim, Min Ho Cho, Hai Jin Kim, Jeong-Ho Kim, Chul Woo Ahn, Kyung Rae Kim, Bong Soo Cha, Sung Kil Lim, Hyun Chul Lee
Journal: Metabolism (2006)
Early serial Q-switched ruby laser therapy for medium-sized to giant congenital melanocytic naevi
Authors: K. Kishi, K. Okabe, R. Ninomiya, E. Konno, N. Hattori, K. Katsube, N. Imanish, H. Nakajima, T. Nakajima
Journal: British Journal of Dermatology (2009)

Medium-sized to giant congenital melanocytic naevi (CMN) are difficult to treat, especially if the lesions appear on the face or extremities where treated areas are visible and cosmesis is important.In infants, nests of pigmented naevus reside more superficially and the skin is more transparent than in adults, so we treated medium-sized to giant CMN with early serial Q-switched ruby laser therapy from infancy.We treated nine patients with medium-sized to giant CMN on the face or upper limbs from 1 month of age with early serial Q-switched ruby laser therapy. The laser power was initially 5 J cm(-2) and increased in 0.5 J cm(-2) steps to a maximum of 10 J cm(-2). There were three treatment sites on the forehead, one on the temple, one on the cheek and four on the upper arm.It took 8-15 treatments for the CMN to become a colour similar to the surrounding skin. The mean number of treatments was 9.6. The colour was reduced to 0-20% of the colour of the baseline lesion in all nine patients. Partial slight repigmentation occurred in eight of these patients. These naevi were treated with an additional one or two Q-switched ruby laser irradiations and successfully lightened for at least 1 year. In the remaining patient, pigmentation returned to a level similar to the original lesion within 1 month of the last treatment. Therefore, the lesion was excised for cosmetic reasons. After the treatment series, the skin texture was fine and no patients had hypertrophic scarring.Although treatment of one patient with the Q-switched ruby laser therapy failed, the remaining patients responded well and had good to excellent skin texture without hypertrophic scarring. Early serial Q-switched ruby laser treatment, starting from infancy, is a promising treatment method for this condition.
INAPPROPRIATE UTILIZATION OF ANTICOAGULATION IN PATIENTS WITH ATRIAL FIBRILLATION: THE GLOBAL ANTICOAGULANT REGISTRY IN THE FIELD (GARFIELD) REGISTRY
Authors: Gregory Lip, Jean-Pierre Bassand, David Fitzmaurice, Samuel Goldhaber, Shinya Goto, Freek Verheugt, Alexander Turpie, Iris Mueller, Sophie Rushton-Smith, Ajay Kakkar
Journal: Journal of the American College of Cardiology (2012)
Long-term outcome of Japanese patients with type 1 autoimmune hepatitis
Authors: Kaname Yoshizawa, Akihiro Matsumoto, Tetsuya Ichijo, Takeji Umemura, Satoru Joshita, Michiharu Komatsu, Naoki Tanaka, Eiji Tanaka, Masao Ota, Yoshihiko Katsuyama, Kendo Kiyosawa, Masanori Abe, Morikazu Onji
Journal: Hepatology (2012)

The long-term outcome of patients with autoimmune hepatitis (AIH) in Japan has not been well-defined. The aim of this study was to clarify the outcome of this disease over a long follow-up period compared with that of the general Japanese population as well as that among patients. A total of 203 AIH patients were enrolled for a mean follow-up period of 131 months. All patients were treated with corticosteroids with or without azathioprine. The overall survival of AIH patients was similar to that of the general population in Japan. The prognosis of AIH subgroups divided according to disease severity, sex, incidence of relapse, liver histology, presence of cirrhosis, probable or definite AIH score, antibody to hepatitis B core antigen antibody positivity, or human leukocyte antigen DR4–positivity did not differ greatly among patients. However, the prognosis of patients experiencing two or more relapses was significantly poorer than that of patients with remission or a single relapse both in univariate ( P &lt; 0.001) and multivariate ( P = 0.020) analyses. The development of liver malignancy was also a possibility among AIH patients with multiple relapses. Severe adverse effects of corticosteroids were rare, even in patients who underwent long-term treatment. Conclusion: Repeated relapses of AIH are significantly associated with a poorer long-term prognosis in Japan. AIH patients can expect a similar prognosis to that of the general population, provided they are adequately managed with continuous low doses of immunosuppressive therapy, especially after the first relapse. (HEPATOLOGY 2012)
778. Rapid Adenoviral Neutralization Assay
Authors: Shuji Kubo, Harris Soifer, John V. Moran, Haig H. Kazazian, Nori Kasahara
Journal: Molecular Therapy (2004)

To improve the efficiency of stable gene transfer in vivo, we have recently developed a novel hybrid vector system, consisting of human L1 retrotransposons with associated transgene cassettes delivered by a high-capacity helper-dependent adenovirus vector (A/RT vector). This hybrid system transduces cells through a two-stage mechanism: in the first (adenovirus) stage, the helper-dependent adenovirus serves as a carrier for efficient delivery and transient expression of its encoded L1/transgene cassette, and in the second (retrotransposon) stage, the L1 retroelement and associated transgene then permanently integrate into the genome of the adenovirus-transduced cells. Proof-of-principle for this novel vector system was demonstrated previously (Hum Gene Ther 12: 1417–28, 2001). We have now developed second-generation A/RT hybrid vectors containing a newly isolated L1 element, L1RP, which exhibits the highest retrotransposition frequency observed to date.
Diagnosis of Hepatobiliary Disease in Infants and Children with Tc-99m-Diethyl-IDA Imaging
Authors: RYOJI OHI, WILLIAM C. KLINGENSMITH, JOHN R. LILLY
Journal: Clinical Nuclear Medicine (1981)

Thirteen infants and children from 42 days to 14 years old with hepatobiliary disease underwent Tc-99m-diethyl-IDA hepatobiliary imaging. Five patients had biliary atresia, four had biliary hypoplasia, two had neonatal hepatitis, and there were single examples of alpha-1-antitrypsin deficiency and congenital hepatic fibrosis. Tc-99m-diethyl-IDA imaging accurately differentiated biliary atresia (complete bile duct obstruction) from other forms of childhood hepatobiliary disease by demonstrating no intestinal radioactivity in the former and the presence of intestinal radioactivity in the latter. In addition, two of four patients with biliary hypoplasia had nonhomogeneous parenchymal transit, and the one patient with congenital hepatic fibrosis showed possible intrahepatic cysts. In conclusion, these preliminary data indicate that Tc-99m-diethyl-IDA provides information not previously available with l-131-rose bengal; this information is likely to be useful in the noninvasive evaluation of childhood hepatobiliary disease.
Off the dial
Authors: D. Spence
Journal: BMJ (2008)

BBC Radio 4 was always crackling away in the background during my childhood. As a teenager I switched to Radio 1, not because I liked the sycophantic disc jockeys but because this was the only music station in remote Orkney. In my late 20s, however, I could stand Radio 1’s vacuous drivel no longer. As I have now been sucked down the inevitable vortex of becoming my father, my own children complain about the constant chatter and discussion on …
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Authors: Chen Zhu, Ana C Anderson, Anna Schubart, Huabao Xiong, Jaime Imitola, Samia J Khoury, Xin Xiao Zheng, Terry B Strom, Vijay K Kuchroo
Journal: Nature Immunology (2005)
Detection of interleukin‐6 (IL‐6) in human bone marrow myeloma cells by light and electron microscopy
Authors: Ken‐Ichi Ohtake, Takahiro Yano, Kazuo Kameda, Tetsuhei Ogawa
Journal: American Journal of Hematology (1990)

We used an Avidin-Biotin peroxidase complex (ABC) immunoperoxidase technique to evaluate the localization of IL-6 of human bone marrow cells in multiple myeloma (MM). The cellular distribution of IL-6 was determined at light and electron microscopic levels. The author's study indicated that cytoplasmic IL-6 was detected only in the myeloma cells of bone marrow cells. Immunoelectron microscopic (immuno-EM) study showed positive reactivity mainly in the perinuclear space (PNS), well-developed rough endoplasmic reticulum (RER), and Golgi area.
So-Called Ichthyosis Linguae, and its Relation to Ichthyosis
Authors: T. Fox
Journal: BMJ (1874)

of cuttinlg *'-f tie hedsl of tleiir subjects, and(I they are nio lornger respected.Th-3 .'tilIaclknowvledge a kinid of niominal sovereignty, feudal in char-acter, hut entitrelv different from that yielded by their neighbours, the Aslianltees, to their kin,g.It is im-ore tllan -probable that the latter peol)le will, now-that the king-ly poxver is broken, become niot very dis- simiilar.Smalt comminunes, jealous of each othel, and constantly at war upon thie ino,;t trivial pretexts, the tribes of the Gold Coast only repeat our-own) carlier history, when the half-niaked Anglo-Saxon fought against thle m)ore disciplined and trained Roman, or, later still, the Celt ineffectuallyaaiiist his Anglo-Norman coniquerors.WNre read of the samne barbar-ous reprisals and mutilation of the deati and wounded, the latter belig only preservel in the prospect of a rainsom.ln other wN-ords, recenit Aifrican wvars are only those of our own more savage periods repealted.Those who lhave studied the histories of the MIiddle A(ges nmuist be struck witlh the similarity of the savage cutomnis.The long knife of the Welsh was in no way dissimilar from that of the Ashaiitee, or the headless trLunks which in those early days wexe no uIncommlBon3 accompamnimet of war.h'liree hundred years sinice, tlle fear of th)e block in Enigland c -as as potenit to cliarm to obedience as is to-day a similar threat from the envoy of an African monarch.It may 1 c said that the miientioni of these peculiar ethnolog-ical anid otler characteristics of the Fantee tribes is of no practical in- terest.1t is a mistake to tllnk so; for, until we learn antd study the left.IIxmori-hage contiutiing, I introdluce the uiterinie pipe to the funcdus, and inject cold water.This failinig, I adld liqlcor ferri perchloricdi and hitherto I have niever lost a case.
REMOVING SPLINTS AND BRACES FROM THE PATIENT
Authors: EMIL S. GEIST
Journal: JAMA (1926)

Our literature is full of directions as to how and when to put the appliance on the patient. It is practically silent about removing it, and yet it requires good judgment to know when to divorce the patient from his splint, be it made of plaster, wood, leather or steel. I often inform my patient that it is easier to tell when to put on a brace than when to take it off. It is the modern and laudable tendency of orthopedic surgery to get away from the brace. As a result of this tendency, we are in possession today of the various arthrodesing and fusing operations, of the different tendon plasties and joint reconstruction operations— of operations to restore balance. But these operations, which are designed to free the patient from brace thraldom, generally require splints and braces in their after-treatment. I have seen what might have been good
Importance of injecting vaccines into muscle
Authors: J R C Seale
Journal: BMJ (2001)

Editor—I am surprised that in her editorial on the importance of injecting vaccines into muscle Zuckerman omitted to mention that intramuscular injection is absolutely contraindicated in patients with congenital bleeding disorders.1 Her own institution contains one of the largest haemophilia centres in the United Kingdom, and its advice—as well as that of all other haemophilia centres as far as I am aware—is that in these patients all parenteral vaccines should be given subcutaneously. If this results in a lower rate of successful immunisation then it must be more than offset by the avoidance of the well documented risk of muscle haematoma.
Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer
Authors: Sandra A. O'Toole, Dorothy A. Machalek, Robert F. Shearer, Ewan K.A. Millar, Radhika Nair, Peter Schofield, Duncan McLeod, Caroline L. Cooper, Catriona M. McNeil, Andrea McFarland, Akira Nguyen, Christopher J. Ormandy, Min Ru Qiu, Brian Rabinovich, Luciano G. Martelotto, Duc Vu, Gregory E. Hannigan, Elizabeth A. Musgrove, Daniel Christ, Robert L. Sutherland, D. Neil Watkins, Alexander Swarbrick
Journal: Cancer Research (2011)

Abstract Hedgehog (Hh) signaling plays an important role in several malignancies but its clinical significance in breast cancer is unclear. In a cohort of 279 patients with invasive ductal carcinoma of the breast, expression of Hh ligand was significantly associated with increased risk of metastasis, breast cancer-specific death, and a basal-like phenotype. A paracrine signature, encompassing high epithelial Hh ligand and high stromal Gli1, was an independent predictor for overall survival in multivariate analysis. In 2 independent histological progression series (n = 301), Hh expression increased with atypia. Hh ligand overexpression in a mouse model of basal breast cancer increased growth, induced a poorly differentiated phenotype, accelerated metastasis, and reduced survival. A stromal requirement for these effects was supported by the lack of similar Hh-mediated changes in vitro, and by stromal-specific expression of Hh target genes in vivo. Furthermore, inhibition of Hh ligand with a monoclonal antibody (5E1) inhibited tumor growth and metastasis. These data suggest that epithelial–stromal Hh signaling, driven by ligand expression in carcinoma cells, promotes breast cancer growth and metastasis. Blockade of Hh signaling to peritumoral stromal cells may represent a novel therapeutic approach in some basal-like breast cancers. Cancer Res; 71(11); 4002–14. ©2011 AACR.
Treatment of Benign Prostatic Hypertrophy With Hydroxyprogesterone Caproate
Authors: Jack Geller
Journal: JAMA (1965)

Benign prostatic hypertrophy is a common disorder which produces clinical symptoms in 30% to 40% of males over 60 years old. Adequate surgical techniques are available for treatment of this disease. However, because the patients are usually elderly, there is frequently coincidental cardiac, renal, or pulmonary pathology adding to the risks of a surgical procedure. A medical therapy which could even delay the need for surgery would be useful. Medical prophylaxis capable of preventing this condition or of arresting its progress would be more useful. Numerous unsuccessful attempts at endocrine therapy for benign prostatic hypertrophy with estrogen or androgen, or both, have been made over the past 30 years. The rationale for such therapy has been based largely upon the hypothesis that altered secretion of testicular steroids occurs and is a factor in the production of benign prostatic hypertrophy. Despite the failure of such therapy in the past, there are
Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle
Authors: Karen A. Lapidos, Yiyin E. Chen, Judy U. Earley, Ahlke Heydemann, Jill M. Huber, Marcia Chien, Averil Ma, Elizabeth M. McNally
Journal: Journal of Clinical Investigation (2004)

Pluripotent bone marrow–derived side population (BM-SP) stem cells have been shown to repopulate the hematopoietic system and to contribute to skeletal and cardiac muscle regeneration after transplantation. We tested BM-SP cells for their ability to regenerate heart and skeletal muscle using a model of cardiomyopathy and muscular dystrophy that lacks δ-sarcoglycan. The absence of δ-sarcoglycan produces microinfarcts in heart and skeletal muscle that should recruit regenerative stem cells. Additionally, sarcoglycan expression after transplantation should mark successful stem cell maturation into cardiac and skeletal muscle lineages. BM-SP cells from normal male mice were transplanted into female δ-sarcoglycan–null mice. We detected engraftment of donor-derived stem cells into skeletal muscle, with the majority of donor-derived cells incorporated within myofibers. In the heart, donor-derived nuclei were detected inside cardiomyocytes. Skeletal muscle myofibers containing donor-derived nuclei generally failed to express sarcoglycan, with only 2 sarcoglycan-positive fibers detected in the quadriceps muscle from all 14 mice analyzed. Moreover, all cardiomyocytes with donor-derived nuclei were sarcoglycan-negative. The absence of sarcoglycan expression in cardiomyocytes and skeletal myofibers after transplantation indicates impaired differentiation and/or maturation of bone marrow–derived stem cells. The inability of BM-SP cells to express this protein severely limits their utility for cardiac and skeletal muscle regeneration.