tbuckley/cabot-search huggingface dataset:
Abstract 5460: Dual efficacy of Lazaroid U-74389G liposomes in glioblastoma mouse model
Authors: Fady Makram Ibrahim, Kemi Cui, Pamela New, Lulu Wang, Hong Zhao, Stephen Wong, Diana S-L Chow
Journal: Cancer Research (2011)

Abstract Purpose: Lazaroid U-74389G (LAZ) is a 21-aminosteroid that has radioprotective effect against radiation-induced lipid peroxidation. In-vitro antiproliferative effect was reported against Glioblastoma primary cell lines. The aim of this study was to use a liposomal formulation in a proof-of-concept efficacy study to evaluate LAZ radioprotective and antiproliferative effects in Glioblastoma mouse model. Methods: LAZ PEGylated liposomes (Lipo G) were developed in our laboratory. Lipo G size was 80-90 nm with Zeta potential of -22mv. Glioblastoma cell line U87-Lexpressing firefly luciferase reporter gene (100,000 cells in 2 μL) was injected intracranially in each male SCID hairless outbred mouse. The mice were randomized among 4 treatment groups (n=8-9, each): brain model (M) without treatment (control), radiation of 2Gy once a week (M+R), Lipo G at 5 mg/kg dose IP twice a week (M+L) and radiation with Lipo G (M+R+L). The treatment lasted three weeks. The tumor size was monitored using non-invasive bioluminescence imaging (BLI), in each mouse, expressed as the relative BLI photon intensity on the second and third week to that of the first measurement. The mice were sacrificed at the end of the third week and the whole brain was harvested for immunohistochemistry examinations. Lipid peroxidation of brain tissues was quantified by measuring malondialdehyde (MDA) as a surrogate biomarker. The survival was evaluated using Kaplan Meier analysis at P = 0.05. Results: The relative BLI intensity was 4002.03±1737.67, 2034±737.72, 1387.36±684.53 and 2498.89±2521.32 % for M, M+R, M+L and M+R+L, respectively. The tumor size of the M+L group was reduced by 65% compared to the control group. For the radiation treated groups (M+R and M+R+L), there was no significant difference in the tumor size suppression compared to the control group. MDA brain concentration in M+L and M+R+L groups was significantly less than that in M+R group (8.27±0.78 and 10.37±3.30 µM/gm vs. 23.09± 3.79 µM/gm). The survival mean was 22.67, 25.33, 25.22 and 27.13 days for M, M+R, M+R+L and M+L groups, respectively. The mean survival duration of LAZ treated groups (M+L and M+R+L) was significantly longer than that of the control group (27.13 and 25.22 day vs. 22.67 day, respectively). Conclusion: LAZ liposomal formulations administered at 5 mg/kg dose delivered a therapeutic concentration of LAZ to the brain for the efficacy of suppressing Glioblastoma tumor growth (65% reduction). The liposomal LAZ also protected the brain tissue from radiation-induced lipid peroxidation by reducing MDA concentration (lipid peroxidation surrogate) to 50%. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5460. doi:10.1158/1538-7445.AM2011-5460
The Toxemias of Pregnancy
Authors: Benjamin Tenney
Journal: New England Journal of Medicine (1948)

THIS review of the toxemias of pregnancy considers the four syndromes involving primarily hypertension with or without albumin in the urine. The first two are essential hypertension and renal disease; they may or may not be influenced by pregnancy. Secondly, pre-eclamptic toxemia and eclampsia are discussed. These conditions are the result of the pregnancy itself. It should be stated in the beginning that clinical diagnosis and classification are frequently difficult and often impossible. If a patient is first seen after she has become pregnant, the presence of hypertension or albuminuria or both offers a very confused picture. There are many . . .
Mammography Screening in Women Under Age 50 Years-Reply
Authors: David M. Eddy
Journal: JAMA (1988)

<h3>In Reply.—</h3> Dr Tabar and colleagues describe a common problem; the rate of technological change often outstrips the pace of research. We would have preferred more current data. Unfortunately, the latest published results from Sweden and Nijmegen, the Netherlands, showed an increase in mortality in this age group. If we had based our analysis on controlled trials using current technology, we would have reported no benefit. When the trials in Canada and Sweden publish results for women younger than age 50 years, the problem should be reassessed. The list by Dr Maher of possible consequences of biopsy is important. Tables 3 and 4 in our original article estimate the frequency of biopsies to enable readers to appreciate their occurrence. The magnitude of the effect of biopsies on life expectancy was too small to deserve emphasis (less than 30 minutes). Dr Lynch and colleagues refer to a group of high-risk women.
TCT-600 Angiographic and clinical outcomes of paclitaxel coated balloon angioplasty versus uncoated balloon angioplasty in Drug Eluting Stent Restenosis: Insights from the PEPCAD-DES study
Authors: Harald Rittger, Johannes Brachmann, Matthias Waliszewski, Ralf Birkemeyer, Christoph Garlichs, Jochen Wöhrle
Journal: Journal of the American College of Cardiology (2012)
Insulin, Membranes, and Metabolism
Authors: Henry T. Ricketts
Journal: JAMA (1968)

Perhaps a more descriptive title, even if less dignified, would be "Insulin: Its Comings, Goings And Doings," for this little book discusses a good deal more than membranes and metabolism. At any rate, its message comes through clearly with remarkable economy in about 150 pages tucked between attractive covers whose orange hue, by design or accident, manages somehow to approximate that of the four-plus "clinitest" reaction for glucose. There are three major sections: Part 1, "Insulin Metabolism," discusses synthesis and secretion of the hormone, its inhibition and degradation, its state in the blood, and its measurement by various methods of immuno- and bioassay. Part 2 deals with insulin effects on carbohydrate, lipid, and protein metabolism. Part 3 is devoted to fundamental but controversial matters such as the relation of insulin structure to its biological activity, the attachment of the molecule to the cell wall, and theories of insulin action. Although
Points: The princess and the patients
Authors: G. L M Sharp
Journal: BMJ (1987)

in addition to Doppler studies.If they judged, again exclusively by their interpretation of the femoral pulse, that there was some aortoiliac disease then blind aortoiliac surgery was advocated in addition to the distal surgery.If angiography showed a localised iliac stenosis we would proceed to angioplasty.This procedure alone might improve the patient's clinical condition or it might subsequently be necessary to proceed to bypass surgery or further angioplasty.Whereas we advocate and use extensively Doppler ultrasound in the management of peripheral vascular disease, we see it as a critical adjunct to angiography in the combined treatment of patients with peripheral vascular disease by both the surgeon and the radio- logist.1
Abstract 3122: The DNA-PK inhibitor NU7441 inhibits non-homologous end joining, enhances radio- and chemosensitivity and increases dependence on homologous recombination in hepatocellular carcinoma cell lines
Authors: Liam Cornell, Joanne M. Munck, Helen L. Reeves, Nicola J. Curtin
Journal: Cancer Research (2012)

Abstract Background DNA double-strand breaks (DSBs), the most cytotoxic lesions induced by ionizing radiation (IR) and anticancer drugs such as topoisomerase II poisons (e.g., doxorubicin), are repaired by non-homologous end joining (NHEJ) and homologous recombination (HR). DNA-dependent protein kinase (DNA-PK), which initiates NHEJ, is up-regulated in hepatocellular carcinoma (HCC) (GEO profiles), possibly contributing to anticancer therapy resistance. To assess DNA-PK as a potential therapeutic target for chemo- and radio-sensitisation in HCC we determined the effect of the DNA-PK inhibitor, NU7441, on DSB repair and cytotoxicity in HCC cells. Methods DNA-PK protein levels and activation by IR (Western blot), DSB levels (y-H2AX foci), HR (RAD51 foci), cell growth (DAPI fluorescence) and cytotoxicity (colony formation) following exposure to IR or doxorubicin was determined in a panel of 6 hepatoma cell lines (HepG2, Hep3B, Huh7, SNU-182, SNU475 and PLC/PRF/5). Results DNA-PK protein concentration and activity did not vary significantly across the panel (±24% and ±37%, respectively) but there were cell-specific sensitivities to IR and doxorubicin (e.g. HepG2 2-fold more resistant than Hep3B). NU7441 significantly sensitised all cells to both doxorubicin (average PF50 4.3±3.0) and IR (average PF50 3.9±1.1) in growth inhibition assays and significantly reduced survival (4.8 to 3.3-fold) in colony forming assays. Following exposure to IR, NU7441 significantly delayed yH2AX focus clearance in all cell lines (e.g. only 13% cleared at 4 hr compared to 50% in control), but increased RAD51 focus formation (3-fold). Conclusion While chemo- and radio-sensitivity in HCC cells was not dependent on DNA-PK expression or activity, NU7441 causes greater than 2-fold chemo- and radiosensitisation in all cells. This was accompanied by a substantial reduction in the rapid phase of DNA repair (NHEJ-dependent) and a shift to a greater reliance on the slower HR repair. DNA-PK inhibitors may have potential as chemo- and radio-sensitisors in hepatoma patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3122. doi:1538-7445.AM2012-3122
Underestimation of Extent and Severity of Coronary Artery Disease by Dipyridamole Stress Thallium-201 Single-Photon Emission Computed Tomographic Myocardial Perfusion Imaging in Patients Taking Antianginal Drugs
Authors: Tali Sharir, Babeth Rabinowitz, Shy Livschitz, Israel Moalem, Jack Baron, Elieser Kaplinsky, Pierre Chouraqui
Journal: Journal of the American College of Cardiology (1998)
Eosinophil cationic protein in tears of normal subjects and patients affected by vernal keratoconjunctivitis
Authors: A. Leonardi, F. Borghesan, D. Faggian, A. Secchi, M. Plebani
Journal: Allergy (1995)

The objectives of this study were to determine: 1) levels of tear eosinophil cationic protein (ECP) in patients with vernal keratoconjunctivitis (VKC); 2) the effect of pharmacologic therapy on ECP release; and 3) the correlation of this mediator with the severity of the disease. Tears were collected from 10 controls and 20 VKC patients before and after therapy for cytologic analysis and ECP measurement by radioimmunoassay. Ocular signs and symptoms were evaluated before tear collection. Mean ECP levels in controls were 7.5 ± 0.4 μg/l, and in VKC patients, 988.3 ± 128 μg/l before therapy ( P &lt;0.001) and 566.3 ± 121 μg/l after therapy ( P &lt;0.005). In dexamethasone (Dex) 0.1%, or cyclosporin A (CsA) 2%, patients (five per group), tear ECP decreased significantly after 7–14 days of treatment. Disodium cromoglycate (DSCG) 4% (five patients) for 14 days did not significantly affect ECP levels. ECP levels were significantly correlated with allergic signs ( P &lt;0.001), symptoms ( P &lt;0.001), and the number of eosinophils in tears (P&lt;0.005). The results of this study suggest that tear ECP levels accurately reflect the clinical status of VKC patients. The measurement of ECP may prove useful not only in the diagnosis and monitoring of allergic disease, but also as an objective parameter for the evaluation of new antiallergic therapies.
Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms.
Authors: G Olaison, K Smedh, R Sjodahl
Journal: Gut (1992)

Forty two Crohn9s disease patients were followed up after ileocolic resection with regard to symptoms and endoscopic appearance of the ileocolic anastomosis. Twenty eight patients resected because of colonic neoplasm served as controls. In all the Crohn9s disease patients the ileal resection margin was disease free macroscopically at operation. In addition, intraoperative ileoscopy was performed in 13 and no sign of residual inflammation in the neoterminal ileum was seen. Endoscopy soon after surgery often showed preanastomotic ileal ulceration before symptoms appeared, whereas no anastomotic lesions were observed in the controls. Thus, 22 of 30 Crohn9s disease patients examined had ulceration of the anastomotic area after three months, but only 10 had developed symptoms indicating relapse (73 v 33%). Corresponding figures in the 30 patients examined after one year were 93 v 37%, and in 14 patients after three years they were 100 and 86% respectively. The inflammatory lesions in all cases were preanastomotic, in the neoterminal ileum, and showed time related progression from aphthae to larger ulcers and stricture. The study suggests that endoscopically observed inflammatory lesions that appear soon after ileocolic resection for Crohn9s disease signify new inflammation and not residual, persistent disease or incomplete anastomotic healing. The data further suggest that despite clinical remission after apparently radical intestinal resection, the bowel is permanently inflamed in Crohn9s disease.
Repair and Reconstruction in the Orbital Region: A Practical Guide
Authors: Bradford Cannon
Journal: JAMA (1967)

Unfortunately, the ophthalmic surgeon is often unfamiliar with the plastic surgical literature, and the plastic surgeon with the ophthalmic literature. Mustarde, the author of Repair and<i>Reconstruction in the Orbital Region</i>, combines in his background a discerning familiarity with both disciplines. True to the traditions of his colleagues in Glasgow, he has compiled a practical guide, the basis of which is an obviously extensive personal clinical experience. From this experience he has assembled a well-balanced monograph depicting reparative procedures for trauma to the lids, the canthi, the orbit and its contents, the eyebrows, and the lacrimal apparatus. Also considered briefly are certain congenital and acquired deformities, and a variety of benign and malignant lesions which require reconstructive procedures. One need only thumb through the pages to be impressed with its teaching value. Each step in a repair has been admirably illustrated with clear photographs, almost always enhanced by instructive line
Tobacco-and-Health Courtroom Drama Continues
Authors: Timothy F. Kirn
Journal: JAMA (1988)

THE LATEST LAWSUIT seeking to hold some tobacco companies liable for smokers' ill health—in this case, for a death that followed more than four decades of smoking—is expected to go to the jury in a matter of days. When she was 16 years old, Rose Cipollone started smoking cigarettes. Cipollone ended up smoking about 1½ packs a day for almost 42 years, despite her husband's nagging and two attempts to quit. In 1981, she was diagnosed as having cancer. Later that year, the upper lobe of her right lung was removed. The rest of the lung was removed the following year and in 1983 surgeons excised her adrenal gland. She died in 1984, at age 59 years. Now, her widower, Antonio Cipollone of Lakehurst, NJ, is seeking unspecified damages from three cigarette companies—Liggett &amp; Meyers, Phillip Morris Companies, and Lorillard Inc— for his wife's death. He hired Mark Z. Edell,
Mechanical restitution of isolated human myocardium is described by two exponential recovery processes
Authors: I C COOPER, C H FRY
Journal: Cardiovascular Research (1988)

Journal Article Mechanical restitution of isolated human myocardium is described by two exponential recovery processes Get access I C COOPER, I C COOPER From the Department of Physiology, United Medical and Dental School (St Thomas' Campus), London SE1 7EH Search for other works by this author on: Oxford Academic PubMed Google Scholar C H FRY C H FRY From the Department of Physiology, United Medical and Dental School (St Thomas' Campus), London SE1 7EH Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 22, Issue 8, August 1988, Page 596, https://doi.org/10.1093/cvr/22.8.596 Published: 01 August 1988
Detection of thrombopoietic activity in plasma by stimulation of suppressed thrombopoiesis
Authors: David P. Shreiner, Jack Levin
Journal: Journal of Clinical Investigation (1970)

Rabbits in which thrombocytosis had been produced by five daily transfusions of platelet concentrates had suppressed endogenous thrombopoiesis, as reflected by decreased incorporation of selenomethionine-(75)Se ((75)SeM) into the circulating platelet mass. Rabbits in which endogenous thrombopoiesis had been suppressed by transfusion-induced thrombocytosis were used to detect thrombopoietic activity in rabbit plasma. Thrombopoietic activity was demonstrated in the plasma of both normal and thrombocytopenic donor rabbits. A dose response relationship was observed between the incorporation of (75)SeM into platelets and the dose of plasma administered. Infusion of 20-150 ml of plasma from thrombocytopenic donors increased the incorporation of (75)SeM into platelets from 52 to 107% above control values. A dose response effect also was seen after infusion of normal plasma, but normal plasma produced less effect than comparable doses of plasma from thrombocytopenic donors. Rabbits with transfusion-induced thrombocytosis appear to be more sensitive assay animals for the detection of thrombopoietic activity than animals with normal platelet counts. Changes in the rate of appearance and levels of (75)SeM may primarily indicate changes in platelet protein or platelet size and are apparently more sensitive indicators of the state of thrombopoiesis than are alterations in the numbers of circulating platelets. The results strongly support the concept of a humoral agent, i.e. thrombopoietin, that acts on megakaryocytes to regulate platelet production.
Long term follow up of chronic hepatitis B virus infection in intravenous drug abusers and homosexual men.
Authors: T Moestrup, B G Hansson, A Widell, E Nordenfelt, I Hagerstrand
Journal: BMJ (1986)

Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug addicts within one year. This shows a difference in the immunological response between homosexual HBsAg carriers and addicts that is not related to infection with human T cell lymphotropic virus type III. Severe histological damage such as chronic aggressive hepatitis, cirrhosis, or primary liver cancer was found in more than half of the homosexual men who underwent biopsy examinations. In drug addicts chronic persistent hepatitis was a regular finding in the absence of markers of delta infection, but in those addicts infected with the delta agent the degree of liver damage was comparable with that found in homosexual men.
Urban Violence in Los Angeles
Authors: Eric Silfen
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Recent theoretical developments merging industrial management techniques with ideas for improving patient care and the associated systems or processes have gained significant momentum.<sup>1</sup>Of the several available methods facilitating process or system improvement, closer alignment of the inputs with the capabilities of the particular process or system and modification of the output structure to represent the need for which the process or system is designed are the most powerful methods for creating the highest leverage for change. After reading the article by Dr Shoemaker and colleagues,<sup>2</sup>it cannot be more intuitively obvious that the needed reform of the American health care system can only occur if we, as a nation, openly discuss and fairly redress the issues that create the inputs that overburden the existing processes, drive the cost, and overtax our financing abilities. Simultaneously, the output of the process must be redesigned, creating a
Merck brings maternity program designed for poor nations to the US
Authors: M. McCarthy
Journal: BMJ (2013)

The drug company Merck on November 19 announced that it will bring its program developed to reduce maternal deaths in impoverished nations to the United States to help address the country’s soaring maternal mortality rate.

The program, Merck for Mothers, is a 10 year $500m (£310m; €371m) global initiative that is currently operating in more than 20 countries, including such nations as Senegal, Uganda, and Zambia.

WHO data show that the US has a maternal mortality rate of …
Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways: Assessment with functional helical thin-section computed tomography☆☆☆★
Authors: Jonathan G. Goldin, Donald P. Tashkin, Eric C. Kleerup, Lloyd E. Greaser, Ulrika M. Haywood, James W. Sayre, Michael D. Simmons, Marika Suttorp, Gene L Colice, Jennifer A. Vanden Burgt
Journal: Journal of Allergy and Clinical Immunology (1999)
Foundation of the British Museum — Main Drainage of London — Putting the Patient at Ease
Authors: John Lister
Journal: New England Journal of Medicine (1953)

THE British Museum and the Natural History Museum this year commemorate the bicentenary of their foundation, but I doubt whether it is generally known that these museums came into being as the direct result of the will of an eminent physician and naturalist, Sir Hans Sloane. G. R. de Beer, F.R.S., director of the Natural History branch, recently described in a leading article in the Times, how this came about.Born in Ireland in 1660, Sloane came to London at the age of nineteen to study medicine. There he met the chemist and physicist Robert Boyle, and in 1683 . . .