tbuckley/cabot-search huggingface dataset:
Folate-responsive neuropathy: report of 10 cases.
Authors: M Manzoor, J Runcie
Journal: BMJ (1976)

Ten patients with severe neurological disease that was clinically indistinguishable from subacute combined degeneration of the spinal cord were found to have normal serum vitamin B12 levels. All were folate deficient. Specific folate treatment led to significant reversal of the neuropathy. These findings indicate the need to review orthodox concepts of the role of folic acid in maintaining the integrity of the nervous system.
Acquired pseudoxanthoma elasticum of the elbow flexures
Authors: S. Lalla, G.M. Kavanagh
Journal: British Journal of Dermatology (2004)

Journal Article Acquired pseudoxanthoma elasticum of the elbow flexures Get access S. Lalla, S. Lalla Department of Dermatology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, U.K. *Department of Dermatology, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, U.K Search for other works by this author on: Oxford Academic Google Scholar G.M. Kavanagh G.M. Kavanagh Department of Dermatology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, U.K. *Department of Dermatology, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, U.K G. M. Kavanagh. E‐mail: gina.kavanagh@luht.scot.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 1, 1 July 2004, Pages 242–244, https://doi.org/10.1111/j.1365-2133.2004.06055.x Published: 01 July 2004
348. Integration Site Analysis of a Helper-Dependent Adenovirus Vector Containing AAV ITRs and 22 kb of the Human Globin LCR
Authors: Hongjie Wang, Tobias Leege, Dmitry Shayakhmetov, Qiliang Li, Thalia Papayannopoulou, George Stamatoyannopolous, Andre Lieber
Journal: Molecular Therapy (2005)

We have previously shown that adenovirus (Ad) vectors containing the Ad serotype 35 fiber (Ad5/35) efficiently transduce human hematopoietic stem cells and that helper-dependent (HD) Ad5/35 vectors containing a 22kb -globin LCR as stuffer DNA and a GFP expression cassette flanked by AAV ITRs (HD-Ad.AAV-LCR) integrate into chromosomal DNA with high frequency. The high integration efficiency makes these vectors potential alternatives to rAAV or retrovirus vectors, which have been shown to preferentially integrate into genes. We performed a detailed integration site analysis of HD-Ad.AAV-LCR vectors in MO7e cells, a cell line that is used as a model for human hematopoietic cells. All integration sites contained the globin LCR and the GFP cassette, often as concatemers. We analyzed a total of 33 independent integration junctions between vector and chromosomal DNA. Ten junctions contained AAV ITR sequences and 23 junctions were formed by the Ad ITR and lacked varying numbers of terminal nucleotides. Based on these results we speculate that HD-Ad.AAV-LCR integration requires ss or ds DNA breaks in the vector genome and that the AAV and /or ITR are prone to such breaks. (Notably the termini of incoming Ad genomes are protected by the Terminal Protein, which hypothetically might prevent efficient Ad integration). Ten out of 33 integrations were within genes, all of them in introns. None of the integrations occured in oncogenes. For three integration sites we sequenced both the 5' and 3' junctions and did not find rearrangements in genomic sequences. A total of 11 out of 33 junctions were localized to chromosome 11 and 4 out of these 11 sites were within the globin LCR (a sequence that was also present in the HD-Ad.AAV-LCR vector). We speculate that tethering of integration to the globin locus/chromosome 11 involves homologous DNA sequences or proteins that are specific to DNA sequences or higher DNA structures. In an attempt to test this, we performed integration analyses after infection of MO7e cells with an HD-Ad5/35.AAV vector that contained short (shuffled) DNA sequences from human chromosome X as stuffer DNA (HD-Ad.AAV-X). None of the 12 analyzed integration sites of this vector were in chromosome 11 and only one was in chromosome X. Interestingly, 10 out 12 HD-Ad.AAV-X integration sites were in exons.
Fatal pulmonary aspiration of oral activated charcoal
Authors: D. Vickers
Journal: BMJ (1988)

threat, although a link with the excess or extent of coronary disease is not yet proved.Preliminary age specific results in our current study of the population of north west London show this too clearly.According to tests of glucose tolerance (75 g glucose) and World Health Organisation criteria for the 269 people aged 50-69 years randomly sampled (about 75% of those eligible), over half of the Gujerati community have "ab- normal" glucose tolerance and heart disease is common.This compares with 37% in evenly sampled Afro-Caribbeans and 25% in whites.With other ethnic matters also in the BMJ may I make a further plea for the careful use of descrip- tive terms without subconscious bias?In their letter on psychiatric illness (30 July, p 359) Drs Gabrielle Milner and Gwilym Hayes describe their patients as Afro-Caribbean, Asian, and British.If the term "Asian" is unsatisfactory "British" is unacceptable; all three groups are British - "white" and "of European origin" are appropriate and without other scientifically creditable terms seem the least objectionable.
PROSTAGLANDIN E1: EFFECT ON HUMAN CUTANEOUS VASCULATURE AND SKIN HISTAMINE
Authors: JORGEN SONDERGAARD, MALCOLM W. GREAVES
Journal: British Journal of Dermatology (1971)

Journal Article PROSTAGLANDIN E1: EFFECT ON HUMAN CUTANEOUS VASCULATURE AND SKIN HISTAMINE Get access JØRGEN SØNDERGAARD, JØRGEN SØNDERGAARD University Department of Dermatology, Newcastle upon Tyne 1. England Search for other works by this author on: Oxford Academic Google Scholar MALCOLM W. GREAVES MALCOLM W. GREAVES University Department of Dermatology, Newcastle upon Tyne 1. England Requests for reprints should be addressed to Dr. Greaves, University Department of Dermatology, Newcastle upon Tyne 1. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 5, 1 May 1971, Pages 424–428, https://doi.org/10.1111/j.1365-2133.1971.tb02527.x Published: 01 May 1971 Article history Accepted: 19 August 1970 Published: 01 May 1971
Clinical diagnosis of ankylosing spondylitis in women and relation to presence of HLA-B27.
Authors: H F Hill, A G Hill, J G Bodmer
Journal: Annals of the Rheumatic Diseases (1976)

Thirty-nine Caucasian women with definite or probable ankylosing spondylitis were tissue typed and the radiographic and clinical features were correlated with the presence of B27 (formerly W27). This investigation showed that the same strong positive correlation observed in men obtains in women between B27 and unequivocal radiographic changes. As such changes develop slowly in women, clinical and laboratory features were identified which were sufficiently characteristic to enable the diagnosis to be reached in advance of decreased spinal mobility. Immobility pain and stiffness and bilateral sacroiliac pain are the most characteristic features, but additional support is provided by the presence of any of the following: onset by age 30, a raised sedimentation rate, peripheral joint involvement, circumthoracic pain, family history, and iritis.
THE ANEMIA OF INFECTION. XIII. STUDIES ON EXPERI-MENTALLY PRODUCED ACUTE HYPOFERREMIA IN DOGS AND THE RELATIONSHIP OF THE ADRENAL CORTEX TO HYPOFERREMIA 1
Authors: G. E. Cartwright, L. D. Hamilton, C. J. Gubler, N. M. Fellows, Helen Ashenbrucker, M. M. Wintrobe
Journal: Journal of Clinical Investigation (1951)

HYPOFERREMIA' cate counts were made in 16 squares of a Fuchs' Rosenthal counting chamber of 0.2 mm.depth.TABLE I Variations in the plasma iron in four consecutive sampls from five dogs Values are in ,Ag.per cent Dog number Sample
Transcatheter Closure of Atrial Septal Defects Without Fluoroscopy
Authors: Peter Ewert, Felix Berger, Ingo Daehnert, John van Wees, Matthias Gittermann, Hashim Abdul-Khaliq, Peter E. Lange
Journal: Circulation (2000)

Background —In an effort to reduce x-ray exposure, we developed a technique for transcatheter closure of atrial septal defects under echocardiographic guidance without fluoroscopy. To assess the efficiency of this procedure for routine use, we compared our initial results with those for the conventional procedure. Methods and Results —Twenty-two randomly selected patients (median age 18 years; range 2 to 66 years) with atrial septal defects (n=13) or patent foramen ovale (n=9) underwent cardiac catheterization for possible interventional defect closure with echocardiography as the only imaging tool. Median stretched diameter was 9 mm (range 6 to 26 mm); median left-to-right shunt over the atrial septal defects was Qp/Qs=1.8 (range 1.5 to 2.6). An Amplatzer septal occluder was successfully implanted in 19 defects without fluoroscopy and in 3 with the help of radiography. After 1 month, complete defect closure was documented in all patients. Compared with the conventional procedure of a control group of 131 patients, procedure times were not significantly different (88 versus 100 minutes; P =0.09). However, the study group received significantly higher doses of propofol for sedation (9.9 versus 5.6 mg/kg body weight; P =0.002) owing to extended transesophageal echocardiography. Conclusions —In the majority of patients in whom transcatheter closure of interatrial communications with the Amplatzer septal occluder is possible, the procedure can be safely performed under echocardiographic guidance without fluoroscopy.
Patent Ductus Arteriosus, Prematurity, and Respiratory Distress Syndrome
Authors: Norman J. Sissman
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The finding by the Birth Defects Monitoring Program of the Centers for Disease Control<sup>1</sup>that patent ductus arteriosus was the most common major malformation in minority groups and the second most common in whites deviates greatly from data published previously. Fyler<sup>2</sup>found patent ductus arteriosus to be only the sixth most common congenital heart defect; Mitchell et al<sup>3</sup>listed patent ductus arteriosus as the third most common heart defect. Both studies reported ventricular septal defects to be two to four times more frequent than patent ductus arteriosus. Explanation of the discrepancy undoubtedly lies in the probability that in the Birth Defects Monitoring Program study the discharge diagnosis of patent ductus arteriosus was made mostly in premature infants whose ductus remained open in the neonatal period secondary to their immaturity and to metabolic abnormalities accompanying the respiratory distress syndrome. In these circumstances, patent ductus arteriosus
Q-WAVE REGRESSION AFTER MYOCARDIAL INFARCTION IS ASSOCIATED WITH INCREASED IMPROVEMENT OF LEFT VENTRICULAR EJECTION FRACTION
Authors: Ronak Delewi, Georges Ijff, Tim van de Hoef, Alexander Hirsch, Lourens Robbers, Robin Nijveldt, Anja Van Der Laan, Pieter van der Vleuten, Albert van Rossum, Felix Zijlstra, Jan Piek
Journal: Journal of the American College of Cardiology (2012)
Decreased heart rate variability in irritable bowel syndrome has no effect on carotid intima-media thickness and pulse wave velocity
Authors: Murtaza Emre Durakoğlugil, Aytun Çanga, Sinan Altan Kocaman, Remzi Adnan Akdoğan, Tuğba Durakoğlugil, Elif Ergül, Halil Rakıcı, Gökhan İlhan, Mehmet Bostan
Journal: Journal of the American College of Cardiology (2013)
Inhibition of LFA‐1/ICAM‐1 and VLA‐4/VCAM‐1 as a therapeutic approach to inflammation and autoimmune diseases
Authors: Helena Yusuf‐Makagiansar, Meagan E. Anderson, Tatyana V. Yakovleva, Joseph S. Murray, Teruna J. Siahaan
Journal: Medicinal Research Reviews (2002)

Abstract This review focuses on providing insights into the structural basis and clinical relevance of LFA‐1 and VLA‐4 inhibition by peptides and small molecules as adhesion‐based therapeutic strategies for inflammation and autoimmune diseases. Interactions of cell adhesion molecules (CAM) play central roles in mediating immune and inflammatory responses. Leukocyte function‐associated antigen (LFA‐1, α L β 2 , and CD11a/CD18) and very late antigen (VLA‐4, α 4 β 1 , and CD49d/CD29) are members of integrin‐type CAM that are predominantly involved in leukocyte trafficking and extravasation. LFA‐1 is exclusively expressed on leukocytes and interacts with its ligands ICAM‐1, ‐2, and ‐3 to promote a variety of homotypic and heterotypic cell adhesion events required for normal and pathologic functions of the immune systems. VLA‐4 is expressed mainly on lymphocyte, monocytes, and eosinophils, but is not found on neutrophils. VLA‐4 interacts with its ligands VCAM‐1 and fibronectin (FN) CS1 during chronic inflammatory diseases, such as rheumatoid arthritis, asthma, psoriasis, transplant‐rejection, and allergy. Block‐ade of LFA‐1 and VLA‐4 interactions with their ligands is a potential target for immunosuppression. LFA‐1 and VLA‐4 antagonists (antibodies, peptides, and small molecules) are being developed for controlling inflammation and autoimmune diseases. The therapeutic intervention of mostly mAb‐based has been extensively studied. However, due to the challenging relative efficacy/safety ratio of mAb‐based therapy application, especially in terms of systemic administration and immunogenic potential, strategic alternatives in the forms of peptide, peptide mimetic inhibitors, and small molecule non‐peptide antagonists are being sought. Linear and cyclic peptides derived from the sequences of LFA‐1, ICAM‐1, ICAM‐2, VCAM‐1, and FN C1 have been shown to have inhibitory effects in vitro and in vivo . Finally, understanding the mechanism of LFA‐1 and VLA‐4 binding to their ligands has become a fundamental basis in developing therapeutic agents for inflammation and autoimmune diseases. © 2002 John Wiley&amp; Sons, Inc. Med Res Rev, 22, No. 2, 146–167, 2002; DOI 10.1002/med.10001
Abstract 5312: Near-infrared multichannel Raman spectroscopy with a 1064-nm excitation wavelength for <i>ex vivo</i> diagnosis of gastric cancer
Authors: Hirotoshi Kikuchi, Toshiki Kawabata, Shigetoshi Okazaki, Yoshihiro Hiramatsu, Megumi Baba, Manabu Ohta, Kinji Kamiya, Tatsuo Tanaka, Hiroyuki Konno
Journal: Cancer Research (2011)

Abstract Background: Gastric cancer is one of the major causes of death in Japan. Endoscopic submucosal dissection (ESD) has been developed for the treatment of early cancers. ESD needs accurate diagnosis of the demarcation line, pathological type and depth of cancer lesions. We have previously reported, using biopsy specimens, the usefulness of the 1064-nm near-infrared multichannel Raman spectroscopy (RAS) system as a novel diagnostic modality for gastric cancer (J Gastroenterol.43(4), 2008). However, our study might not have reflected in vivo use of RAS due to a lack of tissue other than the mucosal layer in the biopsy specimens. Here, we used the 1064-nm near-infrared multichannel RAS ex vivo for optical diagnosis of gastric cancer in surgically resected stomach. Methods: A total of 213 Raman spectra were obtained from 12 cancer lesions and their corresponding non-neoplastic areas in 10 stomachs following resection for gastric cancer. Without any pretreatment, the fresh specimens were measured with a near-infared multichannel Raman spectroscopic system with an excitation wavelength of 1064nm, and Raman spectra specific for the specimens were obtained. To develop optical diagnostic systems for gastric cancer, principal component analysis (PCA) of all the Raman spectra was performed. Results: The averaged Raman spectra of the cancer lesions could be distinguished from those of the non-neoplastic regions. Discrimination analysis of cancer from non-neoplastic regions with 10 principal components revealed that sensitivity, specificity and accuracy of cancer diagnosis was 73%, 73% and 72%, respectively. RAS discriminated between differentiated and undifferentiated cancers, early and advanced cancers, as well as T1a (M) and T1b (SM) cancers with high accuracy (98%, 93% and 98%, respectively). Conclusions: The 1064-nm near-infrared multichannel RAS system is useful not only for gastric cancer detection, but also for discrimination between differentiated and undifferentiated, as well as early and advanced cancers. RAS could help establish indications for endoscopic treatment by eliminating cancer lesions with an undifferentiated component or submucosal invasion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5312. doi:10.1158/1538-7445.AM2011-5312
On Certain Compounds of Albumen with the Acids
Authors: G. S. Johnson
Journal: BMJ (1874)

THE BRITISH MEDICAL _OURNAL.673 ligature, which perhaps it would be best to apply before division, loosening it as sooni as division is complete, to see if bleeding threaten.We may, in the smaller and more easily lifted growths, only pass the wire beneath, wlhile the diseased portion is held up by a forceps.WVe should, however, make sure that the disease is well lifted, and none left.
Erythroblast transferrin receptors and transferrin kinetics in iron deficiency and various anemias
Authors: Koichiro Muta, Junji Nishimura, Hiroshi Ideguchi, Tsukuru Umemura, Hiroshi Ibayashi
Journal: American Journal of Hematology (1987)

Abstract To clarify the role of transferrin receptors in cases of altered iron metabolism in clinical pathological conditions, we studied: 1 number of binding sites; 2 affinity; and 3 recycling kinetics of transferrin receptors on human erythroblasts. Since transferrin receptors are mainly present on erythroblasts, the number of surface transferrin receptors was determined by assay of binding of 125 I ‐transferrin and the percentage of erythroblasts in bone marrow mononuclear cells. 1 The number of binding sites on erythroblasts from patients with an iron deficiency anemia was significantly greater than in normal subjects (p &lt; 0.01). Among those with an aplastic anemia, hemolytic anemia, myelodysplastic syndrome, and polycythemia vera compared to normal subjects, there were no considerable differences in the numbers of binding sites. 2 The dissociation constants (Kd) were measured using Scatchard analysis. The apparent Kd was unchanged (about 10 nmol/L in patients and normal subjects. 3 The kinetics of endocytosis and exocytosis of 125 I‐transferrin, examined by acid treatment, revealed no variations in recycling kinetics among the patients and normal subjects. These data suggest that iron uptake is regulated by modulation of the number of surface transferrin receptors, thereby reflecting the iron demand of the erythroblast.
Simultaneous Combined Pancreatic Test
Authors: S. Nundy, D. Shirley, J. S. M. Beales, N. O'Higgins, R. Heaf, E. E. Pearse, J. P. Lavender, J. H. Baron
Journal: BMJ (1974)

A simultaneous combined pancreatic test can be performed in one morning with only one intubation of the duodenum. The test includes the measurement of exocrine pancreatic secretion of bicarbonate, enzymes, and radioactive selenium, pancreatic scanning, hypotonic duodenography, and cytology of the duodenal aspirate. In the first 70 patients it was found that a single secretion test was of only limited value in detecting pancreatic disease; cytology was the most reliable and scanning the least reliable single test; and that the combined test provided near-complete discrimination between patients with no pancreatic disease, with chronic pancreatitis, and with carcinoma of the pancreas.
THE RIGHTWARD EDGE OF CARDIAC DULLNESS
Authors: W. Gordon
Journal: BMJ (1910)

133 EDICAL J01YDNAl, I -[JURD4IA9f0 Nevertheless, I do not think a study of this malady will leave us as dejected as the subject matter would indicate.In only two of the forms dealt with is the prognosis really bad, and in these Nature mercifully dulls the faculties, and the suffering is quickly lessened.In the other forms, we may in the great majority of instances confidently look forward to recovery.'T'anzi l has graphically described the joys of recovery from this disorder, and with two sentences of his I conclude Ihis paper: "1 Wvhen the melancholic patient has passed through convalescence, and has been able to assure himself that his terrible infirmity is really ended, there are no bounds *D his joy. . . .If melancholia is the most painful of all diseases, its disappearance is the most delightful of all recoveries."
Branch intraductal papillary mucinous neoplasms: just the tip of the iceberg?
Authors: J. Weitz, M. W Buchler
Journal: Gut (2008)

Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have drawn considerable interest in recent years as we begin to learn more about the natural history of this disease. It is now commonly accepted that these tumours can be classified into two main categories according to their origin in the gland—that is main duct IPMN (MD-IPMN) and branch duct IPMN (BD-IPMN). It is also well documented that IPMNs may progress through different stages of dysplasia into invasive carcinoma. It is, however, not well known whether all IPMNs ultimately progress into invasive cancer and if so what the timeline of this process is. In contrast to classical ductal adenocarcinomas of the pancreas, however, where patients always present with fully developed carcinoma with a dismal prognosis, many patients with IPMNs present early enough so that an intervention might prevent the development of pancreatic cancer. In fact, about 8–43% of patients with MD-IPMNs and 54–94% of patients with BD-IPMNs present with non-malignant lesions.1 Whereas it is well accepted that patients with MD-IPMN should undergo resection of the lesion at the time of diagnosis, current guidelines recommend non-surgical management of a certain subgroup of BD-IPMNs.1 Asymptomatic patients with tumours  6 mm) fall into this category. Of note, these recommendations were not based on long-term follow-up of such patients but on the extremely low incidence of invasive cancer of patients initially presenting with these features. Recently, …
Relationship between IL-4 and IL-5 mRNA Expression and Disease Severity in Atopic Asthma
Authors: MARC HUMBERT, CHRISTOPHER J. CORRIGAN, PATRICK KIMMITT, STEPHEN J. TILL, A. BARRY KAY, STEPHEN R. DURHAM
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Atopic asthma is characterized by chronic inflammation of the bronchial mucosa in which eosinophil- and immunoglobulin E (IgE)–dependent mechanisms are believed to be prominent. Therefore, specific proeosinophilic mediators such as interleukin (IL)-5 and essential cofactors for IgE switching in B-lymphocytes such as IL-4 could play a pivotal role in asthma. However, the exact role that individual inflammatory mediators play in the development of the disease in humans is still unknown. Using semiquantitative reverse transcriptase-polymerase chain reaction amplification in bronchial biopsies from 10 atopic asthmatics, we have tested the hypothesis that IL-4 and IL-5 mRNA expression relative to β -actin mRNA correlates with validated indicators of disease severity. IL-4 and IL-5 mRNA copies relative to β -actin mRNA were detected in bronchial biopsies from atopic asthmatics. The numbers of IL-5 mRNA copies relative to β -actin mRNA correlated with disease severity assessed by the Aas asthma score (r = 0.70, p = 0.01), baseline FEV1 (r = − 0.94, p = 0.001), baseline peak expiratory flow rate (r = − 0.77, p = 0.01), peak expiratory flow rate variability over 2 wk (r = 0.69, p = 0.028), and the histamine PC20 (r = − 0.72, p = 0.018). Conversely, the numbers of IL-4 mRNA copies relative to β -actin mRNA did not correlate with asthma severity, but they positively correlated with total serum IgE concentrations (r = − 0.90, p = 0.001). Our present results support the concept that IL-5 may determine asthma clinical expression and severity, and by inference they support the development of IL-5 targeted therapies.