Errors in Meta-analysis Regarding 3CPO Trial
Authors: Yun-Tao Zhao
Journal: Annals of Internal Medicine (2010)

Letters17 August 2010Errors in Meta-analysis Regarding 3CPO TrialYun-Tao Zhao, PhD, MDYun-Tao Zhao, PhD, MDFrom Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-4-201008170-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Goodacre and colleagues for their careful review and comments. We unfortunately judged allocation concealment incorrectly for 3CPO and 2 other studies (1–3). Subgroup meta-analysis of trials with allocation concealment properly classified for these trials still shows an advantage of continuous positive airway pressure over standard therapy for mortality (relative risk, 0.58 [95% CI, 0.37 to 0.90]) and need for mechanical intubation (relative risk, 0.43 [CI, 0.28 to 0.66]).We also thank Dr. Goodacre and colleagues for pointing out that the primary outcome in 3CPO was assessed in almost all participants. We did indeed mistakenly count ...References1. Gray A, Goodacre S, Newby DE, Masson M, Sampson F, Nicholl J; 3CPO Trialists. Noninvasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med. 2008;359:142-51. [PMID: 18614781] CrossrefMedlineGoogle Scholar2. Nava S, Carbone G, DiBattista N, Bellone A, Baiardi P, Cosentini R, et al. Noninvasive ventilation in cardiogenic pulmonary edema: a multicenter randomized trial. Am J Respir Crit Care Med. 2003;168:1432-7. [PMID: 12958051] CrossrefMedlineGoogle Scholar3. Bersten AD, Holt AW, Vedig AE, Skowronski GA, Baggoley CJ. Treatment of severe cardiogenic pulmonary edema with continuous positive airway pressure delivered by face mask. N Engl J Med. 1991;325:1825-30. [PMID: 1961221] CrossrefMedlineGoogle Scholar4. Thygesen K, Alpert JS, White HD, Jaffe AS, Apple FS, Galvani M, et al; Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Circulation. 2007;116:2634-53. [PMID: 17951284] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Yun-Tao Zhao, PhD, MDAffiliations: From Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-analysis: Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema Cui-Lian Weng , Yun-Tao Zhao , Qing-Hua Liu , Chang-Jun Fu , Feng Sun , Yan-Liang Ma , Yan-Wen Chen , and Quan-Ying He Errors in Meta-analysis Regarding the 3CPO Trial Steve W. Goodacre , Alasdair Gray , and David Newby Metrics 17 August 2010Volume 153, Issue 4Page: 278KeywordsContinuous positive airway pressureGlobal healthIntubationIschemiaMortalityMyocardial infarctionNoninvasive ventilationPopulation statisticsRelative riskRisk ratio ePublished: 17 August 2010 Issue Published: 17 August 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...