tbuckley/cabot-search huggingface dataset:
Meeting Report on the 13th International Conference on Human Retrovirology: Human T-Cell Leukemia Virus Research 30 Years after Adult T-Cell Leukemia
Authors: Masao Matsuoka, Toshiki Watanabe, Mari Kannagi, Charles Bangham, Ralph Grassmann, Susan J. Marriott, Patrick Green, Kuan-Teh Jeang
Journal: Cancer Research (2007)

Thirty years ago, in 1977, a new clinical entity called adult T-cell leukemia (ATL) was described in Japan by Takatsuki and colleagues. Subsequently, Poiesz, Ruscetti, Gallo, and coworkers; and Yoshida, Miyoshi, Hinuma, and colleagues isolated a human retrovirus named human T-cell leukemia virus
Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23
Authors: Edwin Liu, Hiroaki Moriyama, Norio Abiru, Dongmei Miao, Liping Yu, Robert M. Taylor, Fred D. Finkelman, George S. Eisenbarth
Journal: Journal of Clinical Investigation (2002)

There is evidence that amino acids 9–23 of the insulin B chain are a major target of anti-islet autoimmunity in type 1 diabetes. Administration of this peptide to NOD mice prevents diabetes, and phase I trials of an altered peptide ligand of B:9-23 are underway in humans. We were interested in long-term subcutaneous therapeutic administration of B:9-23 without adjuvant. To our initial surprise, the peptide consistently induced fatal anaphylaxis in NOD mice after 6 weeks of administration. Anaphylaxis could be blocked by a combination of antihistamine and platelet-activating factor antagonist (but neither alone) or by a combination of anti–IgG receptor and anti-IgE antibodies. High titers of anti–B:9-23 antibodies were induced within 3–4 weeks of immunization with the peptide. Peptide B:13-23 also induced anaphylaxis and was more potent than peptide B:9-23. Antibodies induced by peptide B:9-23 and peptide B:13-23 did not cross-react with each other. Thus, the insulin peptides B:9-23 and B:13-23, even when administered subcutaneously in the absence of adjuvant, can induce a dramatic humoral response leading to fatal anaphylaxis in NOD mice.
The Metabolic Functions of Vitamin B<sub>12</sub>
Authors: William S. Beck
Journal: New England Journal of Medicine (1962)

Metabolic Functions of Vitamin B12 Current knowledge of the metabolic functions of vitamin B12 will be outlined here in a manner calculated to stress the limitations of the evidence. A cursory examination of the relevant literature reveals that vitamin B12 has been implicated in every known metabolic system and a good number of unknown ones. To emphasize the importance of skepticism in such inquiries, the acceptable evidence is presented in three progressively less convincing categories:Enzyme reactions whose requirement for vitamin B12 or its coenzyme form (or forms) has been established in purified cell-free preparations.Cell-free . . .
OVARIAN SARCOMA IN A CHILD ASSOCIATED WITH SEXUAL PRECOCITY
Authors: A. H. Southam
Journal: BMJ (1928)

VRA AROA-NACID _NIA ORA II to 2 feet.-As a nasal, -pharyngeal, ;Qr vaginial douche a blanid mineral water may act as a valuable solvent of lilucus, a cleansing agent, or as a vehicle for other medicanients.
Disaster plans and prevention
Authors: S. Chapman
Journal: BMJ (1996)

The Sunday afternoon murder in April of 35 people and the wounding of another 18 by a lone gunman at Tasmania's Port Arthur tourist site unleashed a programme of unprecedented gun law reform in Australia. If prime minister John Howard and the eight state and territory police ministers have their way, within a few months all parliaments will have legislated for uniform national gun laws. These represent the local gun lobby's worst nightmare: linked licensing of the person who wants to shoot and the registration of his or her guns; a ban on all semiautomatic rifles and pump action shotguns; the end of private owner-to-owner gun sales; and tougher definitions and documentation procedures for both “reason” …
Mechanism of Function of the Mitral Valve Leaflets, Chordae Tendineae and Left Ventricular Papillary Muscles in Dogs
Authors: STEPHEN KARAS, RONALD C. ELKINS
Journal: Circulation Research (1970)

In five dogs (18 to 28 kg) under pentobarbital anesthesia metal clips were placed on the free margin of the anterior and posterior mitral valve leaflets, and on the epicardial surface of the left ventricle at the apex and at the base. After full recovery cineangiograms were taken in the right anterior oblique and right lateral position and the length from the apex of the left ventricle to the free margins of the mitral valve leaflet was measured. The average distance between the apex and the free margin of the anterior leaflet in two dogs and on a clip placed on the chordae tendineae above the anterior leaflet in two dogs was the same during slow ventricular filling, atrial systole, and during ventricular ejection. The average distance between the apex and the free margin of the posterior leaflet in three dogs was also the same during the same time periods in the cardiac cycle. The maintenance of the same distance between the free margin of the mitral valve leaflet and the apex during diastole when the papillary muscle is relaxed and during systole when it is contracted suggests that the papillary muscle contracts isometrically.
Randomised Controlled Trials: A User's Guide
Authors: J.-P. Vader
Journal: BMJ (1998)

The book's subtitle sets the tone. Born of the author's struggle to find, understand, interpret, and use randomised controlled trials, this book is the fruit of years of jotting down questions and searching (often in vain) for answers. It is a concise but complete guide to randomised controlled trials, intended for the long list of their potential users.

Jadad leads us through the basics of randomised controlled trials, the sources of bias at all stages, the tools for assessing the quality of trials, the essentials of reporting and …
Effect of intermittent exposure to sunlight on melanoma risk among indoor workers and sun-sensitive individuals.
Authors: P J Nelemans, H Groenendal, L A Kiemeney, F H Rampen, D J Ruiter, A L Verbeek
Journal: Environmental Health Perspectives (1993)

Intermittent exposure to sunlight is considered to be an important risk factor for melanoma, but the associations reported in most case-control studies are surprisingly weak. The aim of this study was to evaluate whether the incorporation of a subject's background exposure to the sun and pigmentation characteristics (which are assumed to influence a person's susceptibility to sunlight exposure) could produce stronger associations between sunlight exposure and the risk for melanoma. A population-based case-control study was performed in the mid-eastern part of the Netherlands. The study group comprised 141 patients with a histologically verified melanoma and 183 controls with other malignancies who were registered by the same cancer registry. Patients with a lentigo maligna melanoma or an acrolentiginous melanoma were excluded. Information was collected by interviews and physical examination. We categorized subjects as indoor or outdoor workers on the basis of occupational exposure to the sun. Pigmentation characteristics, which are known to be risk indicators for cutaneous melanoma, were summarized as one sun sensitivity score. We used this score to distinguish between sun-sensitive and sun-resistant persons. The odds ratios associated with sunbathing, vacations spent in sunny countries, and sunburns were higher among the indoor workers than among the outdoor workers. After stratification by the sun sensitivity score, the effect of sunbathing, participating in water sports (swimming excluded), vacations to sunny countries, and a history of sunburn was largest for the sun-sensitive persons. The data show a general trend toward higher relative risks among indoor workers and sun-sensitive individuals. The results of this study support the intermittent sunlight hypothesis.
The Longevity Revolution: The Benefits and Challenges of Living a Long Life
Authors: A. Mark Clarfield
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Altered balance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in human atherosclerotic plaque: Evidence from quantitative analysis of gene expression using real-time RT-PCR method
Authors: Takeo Higashikata, Masakazu Yamagishi, Toshio Higashi, Izumi Nagata, Aiji Sakamoto
Journal: Journal of the American College of Cardiology (2003)
Diaphragmatic and Crural FDG Uptake in Hyperventilating Patients: A Rare Pattern Important to Recognize
Authors: Subhash Chander, Eser Lay Ergun, Imad T. Zak, Alkis P. Zingas, David A. Bloom, Richard N. Joyrich, Todd M. Getzen, Mark Shaman
Journal: Clinical Nuclear Medicine (2004)

The authors describe various patterns of F-18 fluorodeoxyglucose (FDG) accumulation in the diaphragm and crura. They present 6 patients in whom incidental diaphragmatic and crural uptake of FDG was observed during positron emission tomography (PET). Hyperventilation is thought to be the potential underlying mechanism of this condition.
Early Post-myocardial Infarction Treadmill Stress Testing
Authors: COLIN M. FULLER
Journal: Annals of Internal Medicine (1981)

Limited (heart rate to less than or equal to 120 beats/min) standardized treadmill stress testing was done before hospital discharge in 40 survivors of uncomplicated acute myocardial infarction. Each patient had subsequent coronary arteriography. Twenty-one had inferior, 10, anterior, and nine, nontransmural infarctions; in 30 patients this was their first infarction. A positive electrocardiographic response or angina, or both, occurred in 15 patients and correctly detected most patients with multivessel disease (sensitivity 67%, predictive value 87%) and patients at risk for coronary events: 35% of positive responders admitted for angina in the first month after discharge versus 4% of patients with a negative test (p less than 0.05). During a 7-month follow-up period, 73% of patients with a positive test result developed angina versus 16% of those with negative test results (p less than 0.001). Thus, predischarge post-myocardial infarction limited stress testing correctly identifies the high-risk subset of patients with multivessel coronary disease and thereby allows intelligent selection of patients for early coronary arteriography.
Neuropathy, Retinopathy, and Glucose-Lowering Treatments
Authors: Zachary T. Bloomgarden
Journal: Diabetes Care (2010)

This is the seventh of a series of articles based on presentations at the American Diabetes Association (ADA) Scientific Sessions held 5–9 June 2009 in New Orleans, Louisiana. This installment pertains to neuropathy, retinopathy, and a number of innovative potential glucose-lowering therapies.

### Neuropathy

Many studies presented at the American Diabetes Association (ADA) Scientific Sessions addressed aspects of neurologic disorders in diabetes. Braza et al. (abstract 569) found that 19% of 76 type 2 diabetic persons receiving metformin for >1 year had vitamin B12 levels <250 ng/ml, and 23% had levels 250–400 ng/ml. (Abstract numbers refer to the Abstracts of the 69th Scientific Sessions of the American Diabetes Association, Diabetes , Vol. 58, Supplement 1, 2009.) Peripheral neuropathy was present in 77 and 23% of these groups, respectively, and was found in 7% of those with normal B12 levels. Deficiency correlated neither with duration of metformin use nor with erythrocyte macrocytosis.

Abrao et al. (abstract 121) found that diabetic persons with periodontal disease or edentulism were 8.1-fold more likely to have loss of sensation to the Semmes-Weinstein 10-g monofilament. Ismail and Venkatesan (abstract 28-LB) found that diabetic versus nondiabetic persons had 94% versus 18% prevalence of sensorineural hearing loss, with mild-to-moderate hearing loss in 40% of diabetic persons with A1C <7% but in 56% of those with higher A1C levels, although noting that their findings might be explained by age differences. Bainbridge and Cowie (abstract 957) found that, among 472 diabetic participants in the National Health and Nutrition Examination Survey (NHANES), hearing impairment occurred 5.6, 5.8, and 2.7 times more often in persons with peripheral neuropathy, with coronary disease, and with A1C ≥7% than in those not having these characteristics.

Ryan et al. (abstract 101-LB) reported neuropsychological test results in 393 nondiabetic and 142 diabetic persons from 11 general medical practices, finding …
Polio encephalitis Due to Poliomyelitis Virus
Authors: G. H. Jennings, J. L. Hamilton-Paterson, F. O. MacCallum
Journal: BMJ (1949)

The case of fatal polio-encephalitis described in detail below is reported because of its interesting clinical picture and because of the striking proof of the diagnosis by intra- cerebral inoculation in a monkey.The similarity of the lesions in the cord of the human victim to those in the monkey inoculated with a filtered saline extract from the child's brain and cord can easily be seen by reference to the illustrations. Case ReportA well-developed child of 3j years was admitted to Edgware General Hospital on Aug. 3, 1948.He had had pertussis at 1 years, but had otherwise been well until he began to attend a nursery school one month before his admission.He was not happy at the school, slept irregularly at night, and was sleepy in the mornings.Three weeks before admission he had an ill- ness of influenzal type lasting one-day, during which he vomited and was febrile and drowsy.On July 31 he was said to have fallen from a swing, though apparently with no untoward effect.However, the next day he became drowsy and slept through much of it, would not eat, complained of abdominal pains, and vomited twice.During the night he awoke three times and complained of headache and pains in the back of the neck and in the legs.On Aug. 2 he still complained of the pains, and some weakness of the left side of the face developed, the face being drawn to the right.Although he was febrile and eager
Combination Chemotherapy of Adult Acute Nonlymphoblastic Leukemia
Authors: J. A. LEVI
Journal: Annals of Internal Medicine (1972)

Twenty-two adult patients with acute nonlymphoblastic leukemia were treated with a regimen consisting of an initial priming dose of hydroxyurea for the first induction course, followed by intermittent courses of cytosine arabinoside, given subcutaneously, and thioguanine. Fifteen of these patients achieved a remission; 9 were complete and 6 partial. The median survival time from diagnosis for all patients was 21.5 weeks, the median remission time was 15 weeks, and the median survival time for those patients who responded to therapy was 34 weeks. Toxic effects were generally not severe, the most disturbing being nausea and vomiting. The subcutaneous use of cytosine arabinoside was well tolerated by the patients and gave results comparable to those reported in series where it was given intravenously. This study confirms the experience of others that cytosine arabinoside in combination with another drug gives better results than when used alone.
Tyropanoate Cholecystography and Reversible Renal Failure
Authors: Mary S. Fisher
Journal: JAMA (1975)

RENAL FAILURE has occurred following cholecystography with iopanoic acid (Telepaque), bunamiodyl sodium (Orabilex), and ipodate (Oragrafin) sodium.<sup>1-3</sup>A more recently introduced contrast medium, tyropanoate sodium (Bilopaque), has not yet been associated with this complication, to my knowledge. <h3>Report of a Case</h3> A 51-year-old man was admitted, profoundly jaundiced, with the diagnosis of alcoholic cirrhosis. In spite of a bilirubin level of 11 mg/100 ml, a gallbladder study was ordered. The dose of cholecystographic contrast agent, tyropanoate sodium, ordinarily used in this department is 3 gm (four capsules), but 5.25 gm (seven capsules) was given. (There was no explanation of this dosage on the patient's record.) The gallbladder did not opacify and an additional 5.25 gm (seven capsules) was given the following evening, 10.5 gm in total. On admission, the patient's blood urea nitrogen (BUN) level was 4 mg/100 ml. After the second dose of tyropanoate, it was 24 mg/100
Stimulating blood supply before ovary transplantation improves success
Authors: Z. Kmietowicz
Journal: BMJ (2009)

Doctors have found that priming the peritoneal area with small pieces of ovarian tissue to stimulate the growth of blood vessels before transplanting a frozen ovary can help to restore ovarian function and improve the chances of pregnancy. 

One woman, who had been menopausal for two years, has had a baby after having the two step procedure. Another woman, who had lost ovarian function for eight and a half years, is pregnant.

Pascal Piver, manager of the in vitro fertilisation centre at Limoges University Hospital in France, described the procedure at a meeting of the European Society of …
Developmental changes in glucose transport of guinea pig erythrocytes.
Authors: T Kondo, E Beutler
Journal: Journal of Clinical Investigation (1980)

The developmental changes in the capacity for D-glucose transport of guinea pig erythrocyte membranes were compared to alterations in the electrophoretic pattern of erythrocyte membrane components. Guinea pig erythrocytes lose their D-glucose carrier functions during development. Good correlation was observed between the loss of glucose uptake and apparent decrease of the zone 4.5 of Coomassie Blue-stained membrane proteins on electrophoresis. Reconstitution of membrane preparations in liposomes resulted in a parallel change in the D-glucose uptake and D-glucose penetration of intact erythrocytes. This suggests that the decrease of D-glucose transport capacity during development is caused by the loss of one or more protein components from the erythrocyte membranes.
Causalgia as a complication of meningococcal meningitis.
Authors: J McLelland, S J Ellis
Journal: BMJ (1986)

Une observation de meningite a meningocoques chez un malade de 19 ans. Le traitement par penicilline intraveineuse est rapidement efficace mais des complications de douleurs causalgiques serieuses sont observees. Efficacite des infiltrations de guanethidine
Cognitive function during hypoglycaemia in type I diabetes mellitus.
Authors: S Pramming, B Thorsteinsson, A Theilgaard, E M Pinner, C Binder
Journal: BMJ (1986)

Neuropsychological testing was carried out in 16 insulin dependent (type I) diabetic men during four periods when mean blood glucose concentrations were (A) 6.3 (SEM 0.13) mmol/l (113.5 (SEM 2.3) mg/100 ml), (B) 2.9 (0.05) mmol/l (52.3 (0.9) mg/100 ml), and (C) 1.8 (0.03) mmol/l (32.4 (0.05) mg/100 ml), all measured during intravenous insulin infusion, and (D) 6.1 (0.13) mmol/l (109.9 (2.3) mg/100 ml), measured after intravenous glucose. The total neuropsychological test score decreased between periods A and B, A and C, and B and C, whereas improvement occurred between periods C and D (all p less than 0.02). These results were not due to changes in individual subjects alone but were consistent for the whole group. During hypoglycaemia there were changes in the patients' estimates of elapsed time, which were underestimated at period C as compared with the estimates at periods A, B, and D (all p less than 0.05). None of the 16 patients noticed symptoms of hypoglycaemia at period A or B, 12 reported symptoms at C, and one at D. Patients with type I diabetes may show a deterioration in neuropsychological skills during periods of asymptomatic subnormal or hypoglycaemic blood glucose concentrations.
STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS
Authors: K. Landsteiner, M. W. Chase
Journal: The Journal of Experimental Medicine (1941)

Experiments with guinea pigs are described which show that under special experimental conditions the intraperitoneal injection of conjugates made with homologous erythrocyte stromata leads to typical skin sensitization of the contact type towards the respective simple chemicals, namely picryl chloride or 2,4-dinitrofluorobenzene. Therefore such sensitivity can be brought about not only by low molecular chemical compounds but by a material which must be regarded as a typical antigen.
John Gilbert Perry
Authors: M. Perry
Journal: BMJ (2003)

Former general practitioner Brandon, Suffolk (b Erdington 1935; q St Mary's Hospital, London, 1958; DTPH), died from metastatic squamous cell carcinoma on 6 August 2003.​2003.




Figure 1




John Perry served as a government medical officer in Kenya from 1959 to 1962 and was a general practitioner in Kent before emigrating to Swaziland in 1968. He entered private practice before moving to Rhodesia as a district medical officer (and later medical superintendent) in the government health department. During this period he saw active service with the Rhodesian Army Medical Corps. He returned to the UK in 1978 and practised in Brandon until his retirement as senior partner in 1996. He leaves a wife, Elaine; four children; and 10 grandchildren.