tbuckley/cabot-search huggingface dataset:
An Evaluation of the Effects of Propranolol on the Symptoms and Electrocardiographic Changes in Patients with Anxiety and the Hyperventilation Syndrome.
Authors: M. M. Suzman
Journal: Annals of Internal Medicine (1968)

s1 May 1968An Evaluation of the Effects of Propranolol on the Symptoms and Electrocardiographic Changes in Patients with Anxiety and the Hyperventilation Syndrome.M. M. Suzman, M.D., F.R.C.P.M. M. Suzman, M.D., F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1194_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptForty patients, presenting with symptoms of anxiety of 1 month to 35 years' duration, were studied before and during the administration of propranolol in the total daily dose of 40 to 160 mg, as well as during placebo substitution, for periods varying from 1 to 40 months.Before treatment, while in the upright position and to a greater extent during voluntary hyperventilation, they invariably exhibited an increase in severity of the symptoms with acceleration of the heart rate, and in 14 patients there was also induction or accentuation of ST segment depression, or T wave inversion, or both, abolished promptly... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. M. Suzman, M.D., F.R.C.P.Affiliations: Johannesburg, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAutonomic characteristics of nonclinical panic and blood phobiaBeta-blockers in anxietyHyperventilation SyndromesMYOCARDIAL ISCHAEMIA: A TIME FOR RETHINKING?Some Psychophysiological Aspects of AnxietyTranquillizing effects of propranolol demonstrated in ratsBeta adrenergic blockade in the circulatory regulation of hyperkinetic statesBiochemical factors in anxiety neurosis 1 May 1968Volume 68, Issue 5Page: 1194-1194KeywordsAnxietyElectrocardiographyHeart rate ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
PARTIAL PROLAPSE OF THE CECUM, ILEUM AND APPENDIX THROUGH A PREFORMED OPENING IN THE GREATER OMENTUM
Authors: Antonio Gentile
Journal: JAMA (1933)

Prolapse of the small intestine through a preformed opening in the greater omentum is an infrequent occurrence. According to the literature, herniation of the large intestine through such an abnormal opening is an extremely rare finding at operation. Including his own, Martzloff<sup>1</sup>found in the literature only sixteen cases of preformed greater omental apertures through which an intestinal loop had prolapsed. In only one of the sixteen was the large intestine the portion of bowel involved. This case, originally reported by Gorski,<sup>2</sup>was included by Martzloff only after some hesitation because of the belief that the opening in the omentum was of inflammatory origin rather than a simple tear. The rareness of the occurrence seems to justify recording this case, which is believed to be the seventeenth of its kind. <h3>REPORT OF CASE</h3><h3>History.</h3> —M. L. F., a Negro girl, aged 14 years, was brought to the University
Assessing changes expression and presentation of NKG2D under the influence of serum factors in breast cancer patients
Authors: Ali Khodadadi, Rayhaneh Roshani, Mehri G Boroujerdnia, Abdolhassan Talaiezadeh, Sara Iranprast
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Breast cancer is the most common cancer in women worldwide. NK cells play an important role in the elimination of tumor cells by NKG2D through lysis of target cells by binding to the MICA proteins. It has been demonstrated that MICA shedding from tumor cell surface. In this study
PLASTIC RECONSTRUCTION OF THE LOWER JAW.
Authors: CARL BECK
Journal: JAMA (1906)

the precipitation had gone far enough, the precipitate sepa- rated very quickly from the rest of the fluid, leaving a liquid which was almost colorless except for a substance which, apparently derived from eosin, resembled superficially fluoro- scene.This titration method lias been tried again and again and invariably has given a stain that is very constant in its results.Aside from this, the stain used was made exactly according to the Hastings formula, and always gave excellent pictures.In order to save time in staining a long glass dish was provided with two glass rods, placed two inches apart.On these rods one could place ten slides and stain them at one time.The appearance of the malarial parasites when stained by this stain is so well known there is no need of discussing this point at this time.
STAPHYLOCOCCIC INFECTION SIMULATING SCARLET FEVER
Authors: HENRY ARANOW
Journal: JAMA (1942)

Scarlet fever was identified by both Sennert and Sydenham as a separate clinical entity during the seventeenth century, but discussions of its etiology remained purely speculative until two centuries later. In 1869 Hallier<sup>1</sup>isolated streptococci from the blood of several patients with scarlet fever, and in the eighties W. H. Power<sup>2</sup>and Klein<sup>3</sup>traced epidemics of the disease to milk obtained from cows with streptococcic mastitis. It is of considerable historical interest that the modern concept of the pathogenesis of scarlet fever was formulated as early as 1893. Thirty years before the classic experiments of the Dicks<sup>4</sup>and Dochez,<sup>5</sup>Bergé<sup>6</sup>had written: Scarlet fever is a local infection; the infectious agent which produces it is the streptococcus, in one of its virulent forms; in the common type of scarlet fever, which one might call pharyngeal, the streptococcus multiplies in the pharyngeal and tonsillar crypts
Stroke Risk After Coronary Artery Bypass Graft Surgery and Extent of Cerebral Artery Atherosclerosis
Authors: Eun-Jae Lee, Kyoung-Hyo Choi, Ju-Seok Ryu, Sang-Beom Jeon, Seung-Whan Lee, Seong-Wook Park, Seung-Jung Park, Jae-Won Lee, Suk-Jung Choo, Cheol-Hyun Chung, Sung-Ho Jung, Dong-Wha Kang, Jong S. Kim, Sun U. Kwon
Journal: Journal of the American College of Cardiology (2011)
Response of simian virus 40 (SV40)-transformed, cultured human marrow stromal cells to hematopoietic growth factors.
Authors: J Nemunaitis, D F Andrews, C Crittenden, K Kaushansky, J W Singer
Journal: Journal of Clinical Investigation (1989)

The response of marrow stromal cells transformed with wild-type simian virus 40 to recombinant growth factors was examined. When transformed stromal cells were plated in semisolid medium without the addition of growth factors, only 0.4% of cells formed colonies while with the addition of recombinant factors such as interleukin 1 (IL-1) or tumor necrosis factor (TNF), up to 10% of the cells formed colonies. Colonies were individually plucked and cell lines were developed that could be analyzed for expression of growth factors. The data show that unstimulated marrow stromal cells lines produced no detectable colony-stimulating activity. However, cell lines derived from "autonomously growing colonies" and from colonies grown with T cell-conditioned medium, with IL-1 alpha or beta, or with TNF alpha produced colony-stimulating activity and transcripts for granulocyte/macrophage-colony-stimulating factor (CSF), granulocyte-CSF, and IL-1 beta. A novel feature of the cell lines derived from colonies was that the production of growth factors was constitutive and persisted in excess of 4 m.
An 80-Year-Old Woman With Vaginal Prolapse
Authors: Geoffrey W. Cundiff
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ROLE OF ADMISSION CARDIAC BIOMARKERS IN RISK STRATIFICATION OF PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION: INSIGHTS FROM THE PLATELET INHIBITION AND PATIENT OUTCOMES TRIAL
Authors: Matthijs Velders, Lars Wallentin, Richard Becker, Adrianus J. van Boven, Anders Himmelmann, Steen Husted, Daniel Lindholm, Joao Morais, Agneta Siegbahn, Robert Storey, Lisa Wernroth, Stefan James
Journal: Journal of the American College of Cardiology (2014)
Relationships between DNA adduct formation and carcinogenesis.
Authors: J A Swenberg, F C Richardson, J A Boucheron, M C Dyroff
Journal: Environmental Health Perspectives (1985)

An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific differences in carcinogenesis to establish the correlations. More recently, we have investigated similar relationships between target and nontarget cell populations within the liver. Chronic exposure to methylating hepatocarcinogens predominantly induces hemangiosarcomas, whereas exposure to ethylating agents causes hepatocellular carcinomas. This cell specificity in carcinogenesis correlates well with the presence of promutagenic DNA adducts. In the case of methylating agents, the nonparenchymal cells accumulate O6-methylguanine whereas the hepatocytes do not. Exposure to ethylating agents leads to accumulation of O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine in hepatocytes. These differences reflect the ability of the two cell populations to repair O6-alkylguanine and the extent of purine and pyrimidine alkylation with methylating and ethylating agents. Hepatocytes of rats exposed to diethylnitrosamine for 28 days have four to five times more promutagenic DNA adducts (O6-alkyldeoxyguanosine and O4-alkyldeoxythymidine) than hepatocytes of rats exposed to nearly equimolar doses of dimethylhydrazine. Both O6-methylguanine and O4-methyldeoxythymidine are rapidly repaired by rat hepatocytes, while only O6-ethyldeoxyguanosine is rapidly repaired. Studies comparing the relationship between the induction of gamma-glutamyl transpeptidase-positive foci, hepatocellular carcinoma and promutagenic lesions such as O4-ethyldeoxythymidine will be useful in understanding associations between the molecular dosimetry of DNA adducts, initiation, and progression of hepatocarcinogenesis.
Serious Hemorrhagic Complications of Anticoagulant Therapy
Authors: Bernard H. Pastor
Journal: JAMA (1962)

THE WIDEPREAD USE of anticoagulants, particularly in the long-term management of nonhospitalized patients, has exposed an increasing number of patients to the risk of hemorrhage. This risk cannot be eliminated entirely, since bleeding is simply an extension of the therapeutic effect of anticoagulants. It can, however, be minimized by adherence to sound principles of anticoagulant therapy which include careful selection of patients, informed and adequate supervision by a physician, and reliable laboratory control. During the past few years we have encountered an increasing number of cases of anticoagulant-induced hemorrhage, and have selected a group which illustrate the disastrous consequences of failure to observe these principles. Report of Cases Case 1.—A 70-year-old man was treated for an acute myocardial infarction at another hospital in 1956, and started on long-term anticoagulant therapy. He took bishydroxycoumarin (Dicumarol) for 5 years without returning for prothrombin time determinations and without the knowledge of his family
The Perilous State of Academic Medicine
Authors: Herbert Pardes
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is general practice losing its way?
Authors: O. Samuel
Journal: BMJ (2000)

Iwas feeling unwell and decided to go and see my doctor. I telephoned the practice to make an appointment but was told that his next available slot was in two weeks' time. The receptionist was very sympathetic and told me that I could see one of the other doctors, but the first time one of them was available was seven days ahead. I said that I wanted to see a doctor straightaway so the receptionist asked me what the matter was. I told her that I hoped that the doctor would be able to tell me that, but only after I had been seen. “No, really,” she said, “I need to know to decide if you are an emergency.” She then added that emergency appointments were only for problems that could not wait and that only one doctor was available that evening to see the “extras.” My friends tell me that many general practices are run with similar waiting times.

> Continuous care by …
FETAL ELECTROCARDIOGRAM, SHOWING CARDIAC MALFORMATION, INCLUDING HEART BLOCK
Authors: Saul D. Larks
Journal: JAMA (1960)

Antenatal electrocardiograms were made from 517 subjects. This has made possible a study of the ECG'S in those cases in which a presumptive diagnosis of congenital heart disease was made antenatally and confirmed postnatally. In three infants heart block was recognized before birth, and two of these died soon after birth; the third survived. In a fourth infant, who died five days after birth, autopsy revealed a coarctation of the aorta and so explained the abnormal ventricular complexes that had been recorded before birth. Antenatal ECG'S not only promise to give information that may help the pediatrician in preparing for postnatal difficulties but also may yield fresh clues to the origin of congenital heart disease.
Abstract 3834: Establishment and characterization of 3D multicellular tumor spheroids as preclinical <i>in vitro</i> models of human colorectal cancer.
Authors: Silvio Daester, Nunzia Amatruda, Diego Calabrese, Paul Zajac, Giulio Cesare Spagnoli, Giandomenica Iezzi, Valentina Mele, Manuele Giuseppe Muraro
Journal: Cancer Research (2013)

Abstract Objective: Multicellular tumor spheroid is a well-known method for three-dimensional in-vitro culture that better represent in-vivo condition. We exploited this system to culture human established colorectal cell lines to investigate how the presence or absence of hypoxic and/or necrotic area, due to oxygen and nutrient gradients, can influence the gene expression profile and the responsiveness to drugs compared to 2D culture and in vivo xenografted cells. Methods: HT29 cell line was cultured as MCTS by hanging drop method. At size-defined time point spheroids were collected and analyzed for the presence of hypoxic and necrotic areas. The expression of a panel of genes related to tumor progression, metastatic behavior, and drug resistance was evaluated by real time PCR on MCTS at different growth stages in comparison to conventional 2D cultures and xenografts generated upon injection of HT29 cells in immunodeficient mice. Results: Based on the absence or presence of hypoxic and/or necrotic core, we identified three different MCTS growth stages: stage 1 (MCTS diameter size &amp;lt;200μm) defined by the absence of hypoxia/necrosis, stage 2 (300-350μm) characterized by the presence of hypoxic, but not apoptotic or necrotic areas, and stage 3 (&amp;gt;500μm) identified by the presence of both hypoxic and necrotic areas. The expression of a panel of genes, including KRAS, p53, and putative cancer stem cell markers CD133, CD44, CD24 was found to be upregulated in stage 1 MCTS, as compared to 2D cultures. Most interestingly a further upregulation of these genes was detected in stage 2 and especially in stage 3. Importantly expression levels in stage 3 were the most similar to those detected in xenografts. Conclusion: Our results showed that culture of established CRC cell lines offer the opportunity to investigate in standardized condition different MCTS stages possibly proving an improved model of in-vivo tumor growth. The drug-responsiveness of tumor cells cultured in 2D and 3D at different spheroid maturation stages is currently being assessed. Citation Format: Silvio Daester, Nunzia Amatruda, Diego Calabrese, Paul Zajac, Giulio Cesare Spagnoli, Giandomenica Iezzi, Valentina Mele, Manuele Giuseppe Muraro. Establishment and characterization of 3D multicellular tumor spheroids as preclinical in vitro models of human colorectal cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3834. doi:10.1158/1538-7445.AM2013-3834
Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor
Authors: Silvia Fischer, Tibo Gerriets, Carina Wessels, Maureen Walberer, Sawa Kostin, Erwin Stolz, Kirila Zheleva, Andreas Hocke, Stefan Hippenstiel, Klaus T. Preissner
Journal: Blood (2007)
Adverse Effects of Amiodarone
Authors: Larry E. Alves
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The recent article by Nademanee and Singh (1982;247:217) did not emphasize the significant potential adverse reactions that we have noted in 100 patients receiving a mean dosage of 461 mg/day of amiodarone hydrochloride. Transient ischemic attacks have occurred in four of our patients and cerebral vascular accidents have occurred in three patients after initiation of amiodarone therapy (followup, one to 20 months; mean, 6.6 months). While our patients have a high incidence of vascular disease, only five patients had cerebral vascular accidents before the initiation of amiodarone therapy. We hope that this will not prove to be a long-term sequelae of amiodarone therapy. Weakness, fatigue, a nonproductive cough, and dyspnea have been symptoms that have responded to diuresis. None of our patients required cessation of therapy because of the adult respiratory distress syndrome. We have reported previously<sup>1</sup>a grading system for amiodarone keratopathy. However, we neglected to
Acupuncture as an antiemetic
Authors: J W Dundee, K R Milligan
Journal: BMJ (1988)

more commonly research becomes incorporated within higher training, so that such experience can be gained with little or no prolongation of senior registrar or equivalent tenure, the more control has to be held over the number of available posts.Geographical spread of senior registrar training and research is another related issue, and I should hate to think that I had made any suggestion which might lead to a perpetuation of the present dis- parity.
Patients' memory for medical information
Authors: R. P C Kessels
Journal: Journal of the Royal Society of Medicine (2003)

When important decisions are to be made, the patient must receive detailed information on the illness, treatment options and prognosis. The shortening of hospital stays and the trend towards outpatient care enhance the need of patients and their families for specific information.1 Practitioners are responding to these demands, yet the amount of information correctly recalled by patients is strikingly small.2 In this review I examine empirical evidence concerning the obstacles to memory for medical information and offer some suggestions for overcoming them.

Clearly, memory for medical information is a prerequisite for good adherence to recommended treatment. Ley's3 model on effective communication in medical practice (see Figure 1) stresses the importance of memory next to factors such as the understanding of information and satisfaction with the treatment. 40-80% of medical information provided by healthcare practitioners is forgotten immediately. The greater the amount of information presented, the lower the proportion correctly recalled;4 furthermore, almost half of the information that is remembered is incorrect.5 For the forgetting of information there are three basic types of explanation—first, factors related to the clinician, such as use of difficult medical terminology; second, the mode of information (e.g. spoken versus written); and, third, factors related to the patient, such as low education or specific expectations.6 Here, I discuss only the second and third, since the communication skills of clinicians have been thoroughly reviewed elsewhere.7,8



Figure 1

Overview of Ley's model on the interactions between patient-related factors and therapy adherence (see Ref. 3)