tbuckley/cabot-search huggingface dataset:
Levothyroxine Prescription
Authors: Anne R. Cappola
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rationalizing Our Hospital System
Authors: Sidney S. Lee
Journal: New England Journal of Medicine (1969)

With costs of both hospital care and hospital construction rising at unprecedented rates, we cannot much longer delay efforts to introduce more rational organization of hospitals within a region. Physicians, trustees and administrators should all be concerned with this problem today. Certain hospital facilities and their use are more easily co-ordinated than others. For example, it is well known that small obstetric and pediatric services are inefficient and much more costly than large services. In addition, there is good reason to believe that it is difficult to maintain all the proper safeguards and supporting services required when the unit is . . .
The exosome complex establishes a barricade to erythroid maturation
Authors: Skye C. McIver, Yoon-A Kang, Andrew W. DeVilbiss, Chelsea A. O’Driscoll, Jonathan N. Ouellette, Nathaniel J. Pope, Genis Camprecios, Chan-Jung Chang, David Yang, Eric E. Bouhassira, Saghi Ghaffari, Emery H. Bresnick
Journal: Blood (2014)
Abstract 4452: Induction of cell and autophagy by the anticancer redox agent mitoquinone is regulated by Nrf2
Authors: V. Ashutosh Rao, Sarah Klein, Naoko Mizuno, Jacek Zielonka, Balarama Kalyanaraman, Emily Shacter
Journal: Cancer Research (2010)

Abstract Mitoquinone (MitoQ) is a synthetically-modified, redox-active ubiquinone compound that accumulates predominantly in mitochondria. We evaluated the potential use of MitoQ as an anti-cancer agent and found that it is 30-fold more cytotoxic to breast cancer cells than to healthy mammary cells. MitoQ caused irreversible inhibition of the clonogenic growth of breast cancer cells by a combination of autophagic and apoptotic cell death mechanisms, with autophagy playing the major role. None of the cytotoxic effects of MitoQ were seen with the parent ubiquinone coenzyme Q10. Growth inhibition from MitoQ was associated with G1/S cell cycle arrest and phosphorylation of the checkpoint kinases Chk1 and Chk2. A possible role for oxidative stress in MitoQ activity is supported by observed increases in products of hydroethidine oxidation (2-hydroxyethidium, ethidium and diethidium) at cytotoxic concentrations of MitoQ. We will present data showing that Nrf2 and Keap1 regulate the response to the oxidative perturbations caused by MitoQ. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4452.
Modulated Dispersion Explains Changes in Arrhythmia Vulnerability During Premature Stimulation of the Heart
Authors: Kenneth R. Laurita, Steven D. Girouard, Fadi G. Akar, David S. Rosenbaum
Journal: Circulation (1998)

Previously, we have shown that a premature stimulus can significantly modulate spatial gradients of ventricular repolarization (ie, modulated dispersion), which result from heterogeneous electrophysiological properties between cells. The role modulated dispersion may play in determining electrical instability in the heart is unknown.To determine if premature stimulus-induced changes in repolarization are a mechanism that governs susceptibility to cardiac arrhythmias, optical action potentials were recorded simultaneously from 128 ventricular sites (1 cm2) in 8 Langendorff-perfused guinea pig hearts. After baseline pacing (S1), a single premature stimulus (S2) was introduced over a range of S1S2 coupling intervals. Arrhythmia vulnerability after each premature stimulus was determined by measurement of a modified ventricular fibrillation threshold (VFT) during the T wave of each S2 beat (ie, S2-VFT). As the S1S2 interval was shortened to an intermediate value, spatial gradients of repolarization and vulnerability to fibrillation decreased by 51+/-9% (mean+/-SEM) and 73+/-45%, respectively, compared with baseline levels. As the S1S2 interval was further shortened, repolarization gradients increased above baseline levels by 54+/-30%, which was paralleled by a corresponding increase (37+/-8%) in vulnerability.These data demonstrate that modulation of repolarization gradients by a single premature stimulus significantly influences vulnerability to ventricular fibrillation. This may represent a novel mechanism for the formation of arrhythmogenic substrates during premature stimulation of the heart.
Screening for Organic Mental Syndromes in the Medically III
Authors: JOHN W. JACOBS
Journal: Annals of Internal Medicine (1977)

A brief mental status questionnaire adapted specifically to diagnose diffuse organic mental syndromes on busy medical wards is developed and tested for reliability and validity. When the 30-item questionnaire was given to 17 medical patients diagnosed by consultation psychiatrists as having a diffuse organic mental syndrome, all scored 20 or less. With hospitalized psychiatric patients the questionnaire was able to differentiate between the "functional psychoses" and diffuse organic brain syndromes. When administered to 69 consecutive medical admissions, fully one third showed marked cognitive limitations. A sample of normals suggested that results may be contaminated by severe cultural or educational variances. We discuss the role of cognitive deficiencies in medical patients, and suggestions are made regarding the broad usefulness of this questionnaire to a medical service.
Phase II Trial of High-Dose Carboplatin and Etoposide With Autologous Bone Marrow Transplantation in First-Line Therapy for Patients With Poor-Risk Germ Cell Tumors
Authors: R. J. Motzer, M. Mazumdar, S. C. Gulati, D. F. Bajorin, P. Lyn, V. Vlamis, G. J. Bosl
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Phase II Trial of High-Dose Carboplatin and Etoposide With Autologous Bone Marrow Transplantation in First-Line Therapy for Patients With Poor-Risk Germ Cell Tumors Get access Robert J. Motzer, Robert J. Motzer Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer CenterNew York, N.Y. and Department of Medicine, Cornell University Medical CollegeNew York Correspondence to : Robert J. Motzer, M.D., Memorial Hospital, 1275 York Ave., New York, NY 10021. Search for other works by this author on: Oxford Academic PubMed Google Scholar Madhu Mazumdar, Madhu Mazumdar Division of Biostatisties, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer CenterNew York, N.Y. and Department of Medicine, Cornell University Medical CollegeNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Subhash C. Gulati, Subhash C. Gulati Division of Hematologic Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer CenterNew York, N.Y. and Department of Medicine, Cornell University Medical CollegeNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Dean F. Bajorin, Dean F. Bajorin Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer CenterNew York, N.Y. and Department of Medicine, Cornell University Medical CollegeNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter Lyn, Peter Lyn Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer CenterNew York, N.Y. and Department of Medicine, Cornell University Medical CollegeNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Vaia Vlamis, Vaia Vlamis Division of Biostatisties, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer CenterNew York, N.Y. and Department of Medicine, Cornell University Medical CollegeNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar George J. Bosl George J. Bosl Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer CenterNew York, N.Y. and Department of Medicine, Cornell University Medical CollegeNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 22, 17 November 1993, Pages 1828–1835, https://doi.org/10.1093/jnci/85.22.1828 Published: 17 November 1993
Clinical, biochemical, and histological studies of osteomalacia, osteoporosis, and parathyroid function in chronic liver disease.
Authors: R G Long, E Meinhard, R K Skinner, Z Varghese, M R Wills, S Sherlock
Journal: Gut (1978)

Twenty of 32 patients with either chronic cholestatic or hepatocellular liver disease had bone pain or recent fractures. On bone biopsy five patients had normal bone, 15 had osteomalacia, five had osteoporosis, and seven had a combination of osteomalacia and osteoporosis. In the presence of osteoporosis, osteomalacia was minimal or absent. There was no biochemical, radiological, or histological evidence of excess parathyroid activity. No significant correlations were demonstrated between the plasma and urinary biochemical findings and the presence of either osteoporosis or osteomalacia and bone biopsy was essential for correct diagnosis. There was no statistical relationship between low serum 25-hydroxy vitamin D values and the presence of osteomalacia. Bone disease was not prevented by regular intramuscular vitamin D2, although biochemical changes were improved. Drugs such as corticosteroids and cholestyramine may be important aetiological factors in hepatic osteodystrophy.
Prevention of Gallstones during Weight Reduction
Authors: Mitchell Shiffman
Journal: Annals of Internal Medicine (1996)

Letters1 March 1996Prevention of Gallstones during Weight ReductionMitchell Shiffman, MDMitchell Shiffman, MDMedical College of Virginia, Richmond, VA 23298-0711Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-5-199603010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Gallstones are one of the most common disorders in the western world and are found in 12% of the adult population. Rapid weight reduction is one of the most significant risk factors associated with gallstone formation. Approximately 25% of persons who lose weight through very-low-calorie diet programs [1] or gastric bypass surgery [2] will develop gallstones. Although I agree with Dr. Kaye that most stones that form during rapid weight reduction are initially asymptomatic, several large epidemiologic studies have shown that each year, 1% to 4% of persons with gallstones will develop biliary colic (15% to 25%, within ...References1. Shiffman ML, Kaplan GD, Brinkman-Kaplan V, Vickers FF. Prophylaxis against gallstone formation with ursodeoxycholic acid in patients participating in a very-low-calorie diet program. Ann Intern Med. 1995; 122:899-905. Google Scholar2. Sugerman HJ, Brewer HJ, Shiffman ML, Brolin RE, Fobi MAL, Linner JH, et al. Prophylactic ursodiol acid prevents gallstone formation following gastric bypass induced rapid weight loss: a multicenter, placebo controlled, randomized, double-blind prospective trial. Am J Surg. 1994; 169:91-7. Google Scholar3. Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am. 1991; 20:1-19. Google Scholar4. Crain K. A computer model for evaluating the costs of cholecystectomy or ursodiol treatment in the management of cholelithiasis. Clin Ther. 1990; 12:250-62. Google Scholar Author, Article, and Disclosure InformationAffiliations: Medical College of Virginia, Richmond, VA 23298-0711 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1996Volume 124, Issue 5Page: 533KeywordsCholecystectomyDietEpidemiologyFatsForecastingGallbladderMedical risk factorsProphylaxisSurgeryWeight loss Issue Published: 1 March 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Comparison of dexamethasone and ondansetron in the prophylaxis of emesis induced by moderately emetogenic chemotherapy
Authors: A.L. Jones, A.S. Hill, D. Cunningham, M. Soukop, A.W. Hutcheon, J. Cassidy, S.B. Kaye, K. Sikora, D.N. Carney
Journal: The Lancet (1991)
Inhibition of Mitochondrial Permeability Transition Prevents Sepsis-Induced Myocardial Dysfunction and Mortality
Authors: Jérome Larche, Steve Lancel, Sidi Mohamed Hassoun, Raphael Favory, Brigitte Decoster, Philippe Marchetti, Claude Chopin, Remi Neviere
Journal: Journal of the American College of Cardiology (2006)
Stumbling blocks pave path to clinical trials for gene therapy
Authors: Beverly Merz
Journal: JAMA (1986)

A he goal is to alleviate human disease—and to do it with a power that has heretofore been reserved for the gods.  This statement describing gene therapy is from the introduction to an award-winning series of articles published in March in the Chicago Tribune . The introductory installment also depicts researchers gearing up to undertake something that would have seemed like science fiction less than five years ago. They hope to break into a patient's cells and replace a malfunctioning gene.  The article reflects two popular—if not prevelent— conceptions about gene therapy: that its effect on the population will be tantamount to that of splitting the atom; and that its realization is just around the corner.  These notions need to be revised, according to panelists at the recent Symposium on Gene Therapy sponsored by the Scientists' Institute for Public Information and Stanford University. The panelists, pioneers of gene therapy, explained
Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung.
Authors: G M Tremblay, J M Sallenave, E Israél-Assayag, Y Cormier, J Gauldie
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Secretory leukocyte proteinase inhibitor (SLPI) and alpha1-proteinase inhibitor (alpha1(PI)) cannot fully explain the total neutrophil elastase (NE) inhibitory capacity detected in bronchoalveolar lavage (BAL) fluid, suggesting the existence of other NE inhibitor(s). In the present study, we measured the concentrations of elafin, a newly described, low-molecular-weight serine proteinase inhibitor, SLPI, and alpha1(PI) in BAL fluids from eight healthy subjects, 13 asymptomatic farmers, seven farmers with active farmer's lung (FL), and seven farmers with previous (Ex) FL. In addition to SLPI and alpha1(PI), elafin was present in BAL fluids from control subjects and asymptomatic farmers, 13 (7-31) and 12 (7-67) mmol/mol of albumin (median and range) respectively. Elafin concentration increased significantly to 105 (38-207) mmol/mol of albumin in farmers with active FL and was also elevated in farmers with Ex FL. Elafin levels were highly correlated with lung inflammatory cell numbers, especially lymphocytes, and the decrease in single-breath diffusion capacity (DLCO). Elafin and SLPI were linked to yet uncharacterized proteins in BAL fluids. In conclusion, elafin is a constituent of BAL fluid from normal subjects and is found in enhanced concentrations in FL and in farmers with lymphocytic alveolitis. This suggests that elafin may play a role in lung homeostasis and inflammation.
Body building on drugs
Authors: I. J. MacQueen
Journal: BMJ (1967)

We present a case of a man who experienced night sweats, abdominal pain and fever for over 3 months, with incomplete response to broad-spectrum intravenous antibiotics. Although CT imaging was insufficient to identify the cause for his chronic abdominal pain, the abnormality of a ‘misty mesentery’ was crucial in guiding further investigation. The final diagnosis of chronic appendicitis was made through laparoscopic and pathological examination. This case highlights the utility of a collaborative diagnostic effort between disciplines. Chronic appendicitis can cause lingering abdominal pain. Early recognition and appropriate referral can save patients months and even years of unnecessary suffering.
Ibuprofen increases soft tissue infections in children
Authors: C. A C. Ospina, A. Salcedo
Journal: BMJ (2008)

Because ibuprofen is more effective as monotherapy than paracetamol in controlling fever in children Hay and colleagues conclude that ibuprofen should be administered first to feverish children in discomfort.1 Paracetamol should be added after 24 hours if recovery is not …
Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy.
Authors: P de Lonlay, J C Fournet, J Rahier, M S Gross-Morand, F Poggi-Travert, V Foussier, J P Bonnefont, M C Brusset, F Brunelle, J J Robert, C Nihoul-Fékété, J M Saudubray, C Junien
Journal: Journal of Clinical Investigation (1997)

Sporadic persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or nesidioblastosis is a heterogeneous disorder characterized by profound hypoglycemia due to inappropriate hypersecretion of insulin. An important diagnostic goal is to distinguish patients with a focal hyperplasia of islet cells of the pancreas (FoPHHI) from those with a diffuse abnormality of islets (DiPHHI) because management strategies differ significantly. 16 infants with sporadic PHHI resistant to diazoxide and who underwent pancreatectomy were investigated. Selective pancreatic venous sampling coupled with peroperative surgical examination and analysis of extemporaneous frozen sections allowed us to identify 10 cases with FoPHHI and 6 cases with DiPHHI. We show here that in cases of FoPHHI, but not those of DiPHHI, there was specific loss of maternal alleles of the imprinted chromosome region 11p15 in cells of the hyperplastic area of the pancreas but not in normal pancreatic cells. This somatic event is consistent with a proliferative monoclonal lesion. It involves disruption of the balance between monoallelic expression of several maternally and paternally expressed genes. Thus, we provide the first molecular explanation of the heterogeneity of sporadic forms of PHHI such that it is possible to perform only partial pancreatectomy, limited to the focal somatic lesion, so as to avoid iatrogenic diabetes in patients with focal adenomatous hyperplasia.
The Perinatal Group B Streptococcal Problem: More Questions Than Answers
Authors: Ralph D. Feigin
Journal: New England Journal of Medicine (1976)

IT was not until 1938, five years after Lancefield introduced streptococcal precipitin typing, that streptococci belonging to Group B were related causally to severe human disease.1 That Streptococcus agalactiae could be an important cause of perinatal morbidity and mortality was documented by Hood and his associates2 in 1961 and by Eickhoff and his co-workers3 in 1964. Since 1971, Group B beta-hemolytic streptococcal infection in neonates has become a subject of increasing attention and concern largely because in many centers they are now the organism associated most frequently with neonatal septicemia.The epidemiology and pathogenesis of Group B streptococcal infection in . . .
In vivo efficacy of platelet-delivered, high specific activity factor VIII variants
Authors: Teshell K. Greene, Cheng Wang, Jessica D. Hirsch, Li Zhai, Jamie Gewirtz, Michael A. Thornton, Hongzhi Z. Miao, Steven W. Pipe, Randal J. Kaufman, Rodney M. Camire, Valder R. Arruda, M. Anna Kowalska, Mortimer Poncz
Journal: Blood (2010)
The Professional Ethics of Billing and Collections
Authors: Mark A. Hall, Carl E. Schneider
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-13 Final 2-year Results of the APPOSITION III Study Evaluating the Use of the STENTYS Self-apposing Stent for the Treatment of ST-segment Elevation Myocardial Infarction in the Setting of Primary PCI
Authors: Karel T. Koch, Maik J. Grundeken, Nicola S. Vos, Alexander J. IJsselmuiden, Robert J. Van Geuns, Rainer Wessely, Thomas Dengler, Alessio La Manna, JOHANNE SILVAIN, Gilles Montalescot, René Spaargaren, Jan G. Tijssen, Giovanni Amoroso
Journal: Journal of the American College of Cardiology (2014)