tbuckley/cabot-search huggingface dataset:
Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.
Authors: L Millet, H Vidal, F Andreelli, D Larrouy, J P Riou, D Ricquier, M Laville, D Langin
Journal: Journal of Clinical Investigation (1997)

Uncoupling protein-2 and -3 (UCP2 and UCP3) are mitochondrial proteins that show high sequence homology with the brown adipocyte-specific UCP1. UCP1 induces heat production by uncoupling respiration from ATP synthesis. UCP2 is widely expressed in human tissues, whereas UCP3 expression seems restricted to skeletal muscle, an important site of thermogenesis in humans. We have investigated the regulation of UCP2 and UCP3 gene expression in skeletal muscle and adipose tissue from lean and obese humans. UCP2 and -3 mRNA levels were not correlated with body mass index (BMI) in skeletal muscle, but a positive correlation (r = 0.55, P < 0.01, n = 22) was found between UCP2 mRNA level in adipose tissue and BMI. The effect of fasting was investigated in eight lean and six obese subjects maintained on a hypocaloric diet (1,045 kJ/d) for 5 d. Calorie restriction induced a similar 2-2.5-fold increase in UCP2 and -3 mRNA levels in lean and obese subjects. To study the effect of insulin on UCP gene expression, six lean and five obese subjects underwent a 3-h euglycemic hyperinsulinemic clamp. Insulin infusion did not modify UCP2 and -3 mRNA levels. In conclusion, the similar induction of gene expression observed during fasting in lean and obese subjects shows that there is no major alteration of UCP2 and -3 gene regulation in adipose tissue and skeletal muscle of obese subjects. The increase in UCP2 and -3 mRNA levels suggests a role for these proteins in the metabolic adaptation to fasting.
Rapidly Performed Pyloroplasty.
Authors: W. J. Mayo
Journal: JAMA (1897)

Rochester, Minn., Oct. 18, 1897. <h3>To the Editor:</h3> —My article on "Cicatricial Stenosis and Valve Formation as a Cause of Pyloric Obstruction, with a Report of Five Cases Relieved by Operation," published in theJournalOct. 16, 1897, contains three cuts of a method of rapidly performing pyloroplasty which add largely to the interest of the publication. These cuts were furnished me by Dr. A. J. Ochsner of Chicago and represent a method original with him, and not with myself, as would appear. The proofs which I examined did not contain the diagrams and by some oversight their source was not properly acknowledged. Very truly yours,
Literature review and recommendations for clinical application of small-bowel capsule endoscopy, based on a panel discussion by international experts
Authors: K. Mergener, T. Ponchon, I. Gralnek, M. Pennazio, G. Gay, W. Selby, E. Seidman, C. Cellier, J. Murray, R. de Franchis, T. Rösch, B. Lewis
Journal: Endoscopy (2007)

Correction to: Literature review and recommendations for clinical application of small-bowel capsule endoscopy, based on a panel discussion by international expertsEndoscopy 2007; 39(10): 895-909DOI: 10.1055/s-2007-966930
Expansive Arterial Remodeling Is Associated With Increased Neointimal Macrophage Foam Cell Content
Authors: Eugen Ivan, Jaikirshan J. Khatri, Chad Johnson, Richard Magid, Denis Godin, Sudeshna Nandi, Susan Lessner, Zorina S. Galis
Journal: Circulation (2002)

Background — Recent observations associate plaque instability with expansive arterial remodeling, suggesting a common driving mechanism. Methods and Results — To demonstrate that macrophages, a characteristic of vulnerable plaques, also assist in expansive remodeling, we compared carotid artery remodeling due to formation of experimental macrophage-rich and macrophage-poor lesions in the flow cessation model in hypercholesterolemic apolipoprotein E knockout (ApoE KO) and wild type (WT) mice. After ligation, macrophages started to rapidly accumulate in ApoE KO but not in WT carotid artery lesions. Macrophage-rich ApoE KO intimal lesions grew fast, typically occluding within 14 days, despite a tripling of the vessel area. Outward remodeling of macrophage-rich ApoE KO arteries positively correlated with macrophage area ( r 2 =0.600, P &lt;0.001). To investigate potential mechanisms of macrophage-enabled expansive remodeling, we compared levels of matrix metalloproteinases in homogenates of macrophage-rich and macrophage-poor carotid arteries. Gelatinolytic activity of macrophage-rich lesions increased faster and reached maximal levels several fold higher than in the macrophage-poor WT lesions. Conclusions — Our results suggest that macrophages facilitate expansive arterial remodeling through increased matrix degradation by matrix metalloproteinases. This initially favorable remodeling action may eventually increase the vulnerability of macrophage-rich atherosclerotic plaques.
The effects of adding torasemide to standard therapy on peak oxygen consumption, natriuretic peptides, and quality of life in patients with compensated left ventricular systolic dysfunction
Authors: Sanjay Gupta, Carolyn Waywell, Nandkumar Gandhi, Nigel Clayton, Brian Keevil, Andrew L. Clark, Leong L. Ng, Nicholas Brooks, Ludwig Neyses
Journal: European Journal of Heart Failure (2010)
Differential Effects of Angiotensin II on Cardiac Cell Proliferation and Intramyocardial Perivascular Fibrosis In Vivo
Authors: Pauline E. McEwan, Gillian A. Gray, Lorcan Sherry, David J. Webb, Christopher J. Kenyon
Journal: Circulation (1998)

Growth effects of angiotensin II (Ang II) contribute to cardiac remodeling. Remodeling, in turn, may be influenced by proliferation of nonmyocytes. The aims of this study were to determine in vivo which cardiac cell types proliferate in response to Ang II, to evaluate whether proliferation is mediated by the Ang II AT1 receptor, and to establish whether blood pressure affects cell proliferation by comparing proliferation in the normotensive right atrium and ventricle and pressure-overloaded left ventricle.Groups of 8 Wistar rats were implanted with miniosmotic pumps releasing 5-bromo-2'-deoxyuridine (BrdU) as a cell proliferation marker for 2 weeks. Two groups received Ang II infusions via a second minipump and drinking water+/-losartan. Two groups received vehicle+/-losartan. Cell proliferation was assessed as the percentage of nuclei that incorporated BrdU. Ang II increased proliferation within medial vascular smooth muscle cells (VSMCs) and in associated adventitial/interstitial fibroblasts of intramyocardial coronary arterioles but decreased proliferation of myoendothelial cells. Despite increased blood pressure, proliferation in atria and ventricles was similar. Aldosterone levels were not significantly elevated, suggesting direct proliferative effects of Ang II. Losartan reduced Ang II-induced VSMC and adventitial fibroblast proliferation but had no effect on myoendothelial cell proliferation.These results indicate direct, differential effects of Ang II on proliferation of atrial and ventricular nonmyocytes. VSMC and fibroblast proliferation is AT1 receptor-dependent, whereas myoendothelial cells are controlled by an AT1-independent mechanism. The effects are independent of aldosterone and blood pressure and have important implications in renin-dependent hypertension and chronic cardiac failure when circulating Ang II is elevated.
Further Electrocardiographic Observations on Direct Epicardial Potentials in Congenital Heart Lesions
Authors: R. H. WASSERBURGER, W. P. YOUNG, K. SIEBECKER, L. K. HAWKINS, B. BAMFORTH, J. T. KING
Journal: Circulation (1962)

Epicardial electromotive potentials have been recorded at the time of open thoracotomy on 130 patients, 124 having congenital heart disease. These data confirm characteristic epicardial potentials with right ventricular preponderance, incomplete right bundle-branch block, and complete right bundle-branch block, as well as with normal rS and rSr' complexes, as identified in the right precordial leads of unipolar electrocardiograms. The major differential feature between right ventricular preponderance and incomplete right bundle-branch block is a critical difference in onset of depolarization of the free wall of the right ventricle. This measurement, AB of figure 1, is 0.02 second with right ventricular preponderance and 0.03 second or greater with incomplete right bundle-branch block. Although rR' or rsR' right precordial QRS complexes are identified with both right ventricular preponderance and incomplete right bundle-branch block, the broad left ventricular S wave of the incomplete right bundle-branch block aids in differentiating them on the conventional electrocardiogram. A tall predominant late R wave in aV R , arising from the R' component of the rR' potential of the hypertrophied right ventricular outflow tract, serves to denote an advanced degree of right ventricular hypertrophy, whether the classic pattern of right ventricular preponderance or an incomplete right bundle-branch block associated with right ventricular preponderance presents on the routine electrocardiogram. The apparent slurred or pure R waves, the Rs and qR right precordial QRS complexes, seen with instances of right ventricular preponderance or incomplete right bundle-branch block, are actually rR' or rsR' complexes. Additional exploratory right anterior chest leads will invariably bring out the initial septal r wave component. The rR' or rsR' potentials of right ventricular preponderance or right bundle-branch block arise from a relatively selective site of the high medial outflow tract of the right ventricle.
Avastin Scintigraphy in Surveillance of Bevacizumab Treatment in a Patient With Neurofibromatosis Type 2
Authors: Michelle W.J. Versleijen, Berit M. Verbist, Jef J.S. Mulder, Lioe-Fee de Geus-Oei, Carla M.L. van Herpen
Journal: Clinical Nuclear Medicine (2014)

A patient with neurofibromatosis type 2 (bilateral vestibular schwannomas) was treated with bevacizumab (anti-vascular endothelial growth factor [VEFG] monoclonal antibody). The left-sided tumor showed intense uptake on pretreatment 111In-bevacizumab scintigraphy, indicating VEGF production in the tumor, and no uptake 4 weeks later, demonstrating effective binding of nonradiolabeled bevacizumab to the VEGF produced in the tumor. The right-sided tumor showed no tracer uptake at any time point. Significant tumor volume reduction (assessed with MRI) and hearing improvement were observed on the left side. 111In-bevacizumab scintigraphy may be a promising upfront patient selection tool to identify patients who may benefit from expensive bevacizumab treatment.
Safety Profile of Extended-Release Niacin in the AIM-HIGH Trial
Authors: Todd J. Anderson, William E. Boden, Patrice Desvigne-Nickens, Jerome L. Fleg, Moti L. Kashyap, Ruth McBride, Jeffrey L. Probstfield
Journal: New England Journal of Medicine (2014)

To the Editor: The results of the Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial were published in the Journal in 2011.1 This study showed no incremental clinical benefit from the addition of high-dose extended-release niacin (Niaspan, AbbVie) to statin therapy during a 36-month mean follow-up period in 3414 patients who had stable atherosclerotic disease, low baseline levels of high-density lipoprotein (HDL) cholesterol, and elevated triglyceride levels. In that article, we provided data on adverse events resulting in a reduction in the dose or discontinuation of the study drug. These results were . . .
Drs Lewis and Kelly
Authors: Larry R. Kirkland
Journal: JAMA (1984)

<h3>To the Editor.—</h3> First, we are all in debt to Dr Marc H. Hollender for unearthing the remarkable 1899 article, "The Gynecologic Consideration of the Sexual Act," by Denslow Lewis, MD.<sup>1</sup>One cannot help being impressed in considering how Dr Lewis compiled such information in the late 19th century. However, my main purpose in writing is to assuage those gynecologists who may have been upset on reading what one of their heroes—Dr Howard A. Kelly—said in response to Dr Lewis' original presentation. Kelly was a product of his era, and he was a prude to the core. Even the title of his main biography<sup>2</sup>(written by an acquaintance of many years) is telling. There is no denying his immense contributions to gynecology and surgery, but during his lifetime, he was constantly embroiled in social issues. H. L. Mencken was a contemporary in Baltimore and once wrote of Kelly,
The evolution of peripartal heart failure in Zaria, Nigeria. Some etiologic factors.
Authors: S J Fillmore, E H Parry
Journal: Circulation (1977)

The subsequent course of 173 women with severe congestive heart failure hospitalized within 6 months of delivery has been analyzed after 4 to 7 year follow-up periods. Forty-seven normotensive women and 50 women hypertensive only during the initial 48 hours have little long term morbidity. Thirty-six women with hypertension initially improved, but many are now showing enlarging cardiac silhouettes. Morbidity is increasing in this group. A similar, less severe pattern is developing in 36 women with intermittent hypertension. The uniquely high incidence of this condition in Zaria is associated with several locale factors. These Hausa-Fulani women eat large quantities of a local lake salt, kanwa, for 40 days postpartum. The syndrome is markedly more common in the hot rainy season, when evaporative water loss is less, than in the dry season. The first postpartum days are spent confined to bed in a small heated room. Once or twice daily the new mother is given hot baths with branches which have been dipped in boiling water. The combination of excessive sodium intake and diminished evaporative water excretion seems to precipitate failure in both normotensive and hypertensive patients.
Intraportal transplantation of human bone marrow mesenchymal stem cells in pigs with fulminant hepatic failure
Authors: Suttiruk Jitraruch, Ragai R. Mitry, Anil Dhawan
Journal: Hepatology (2012)

We read with interest the article by Li et al.1 The authors demonstrated that intraportal transplantation of human bone marrow mesenchymal stem cells (hBMSCs) in pigs with fulminant hepatic failure (D-galactosamine model), significantly improved their long-term survival (87%) compared to both peripheral vein transplantation and sham groups (0%). One of the most interesting findings is that 30% of the recipient liver was repopulated by transplanted hBMSC-derived hepatocytes in surviving animals 2 to 10 weeks post-transplantation. We also learn from this study that hBMSC-derived hepatocytes were well differentiated and expressed hepatocyte-specific markers for albumin, CK8, G6PD, and HNF-1α. In addition, high levels of human-derived albumin were identified in the pig sera; 2.02 ± 0.35 g/L and 3.92 ± 0.5 g/L at week 2 and week 10, respectively. We wonder, and as reported by others, that mature hepatocyte should also express human leukocyte antigen-1 triggering host immune response leading to xenograft rejection.2-4 Do the authors have experimental data to show that hBMSC-derived hepatocytes did not trigger an immune response in these animals? The authors mention that both treated and control groups did not receive any medications or infusions. Usually, in fulminant hepatic failure patients, complications like hypoglycemia, dyselectrolytemia, and renal dysfunction are very common. Data on blood glucose, serum sodium, and renal function would be of interest in all 3 groups to understand the severity of liver failure, particularly if we are contemplating translation of this work to humans. Suttiruk Jitraruch M.D.*, Ragai R. Mitry Ph.D.*, Anil Dhawan M.D.*, * Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, London, United Kingdom.
THROMBO-PHLEBITIS MIGRANS
Authors: T. G. Moorhead, L. Abrahamson
Journal: BMJ (1928)

TITROMBO-PHLEBITIS MIGRANS.r V Tt hBRT are only separated from uiticarial (anaphylactoid) purpura and urticaria by the degree of the capillaiy defect.4. Splenectoemy slhould have a permanenit beneficial effect, tlhouglh protection fromii capillary haemoi'hlages mlay not be complete.
Which features of the metabolic syndrome predict the presence of angiographic coronary artery disease?
Authors: Sandra P. Reyna, Joseph B. Muhlestein, John F. Carlquist, Dale G. Renlund, Donald L. Lappé, Tami L. Bair, Robert R. Pearson, Benjamin D. Horne, Chloe A. Allen Maycock, Stephanie V. Moore, Jeffrey L. Anderson
Journal: Journal of the American College of Cardiology (2003)
Is Embolic Risk Conditioned By Location of Deep Venous Thrombosis?
Authors: KENNETH M. MOSER
Journal: Annals of Internal Medicine (1981)

Sixty-eight patients clinically suspected of having (33), or at high risk for (35), deep venous thrombosis were studied with contrast venography, radiofibrinogen leg scanning, and impedance plethysmography as well as ventilation and perfusion lung scans. Thrombosis limited to the veins in the calf of the leg (unilateral or bilateral) was shown by venography in 12 patients. None of these patients had clinical symptoms or scan results indicating embolism. Fifteen patients had thrombosis involving proximal (thigh) as well as distal (calf) veins by venography. Eight had scan evidence of embolism, although only one was symptomatic. The combination of radiofibrinogen and impedance tests allows accurate detection of both the presence and location of deep venous thrombosis. The availability of sensitive and specific, noninvasive methods for detecting and localizing venous thrombosis, as well as the apparently low embolic risk of calf-only thrombosis may condition future approaches to prophylaxis and treatment of patients with or at high risk for deep venous thrombosis.
Sudden Death Due to Neck Blows Among Amateur Hockey Players
Authors: B. J. Maron
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An infiltrating rheumatoid nodule?
Authors: A H Isdale, P S Helliwell
Journal: Annals of the Rheumatic Diseases (1992)

The case is presented of a patient with mild rheumatoid arthritis who developed an enlarged painful tissue mass in the left lower leg. Although the history, clinical, and imaging appearances suggested that it was a soft tissue sarcoma, a biopsy specimen showed histological features consistent with either a rheumatoid nodule or subcutaneous granuloma annulare.
Risk factors which predispose first-time traumatic anterior shoulder dislocations to recurrent instability in adults: a systematic review and meta-analysis
Authors: M Olds, R Ellis, K Donaldson, P Parmar, P Kersten
Journal: British Journal of Sports Medicine (2015)

Recurrent instability following a first-time anterior traumatic shoulder dislocation may exceed 26%. We systematically reviewed risk factors which predispose this population to events of recurrence.A systematic review of studies published before 1 July 2014. Risk factors which predispose recurrence following a first-time traumatic anterior shoulder dislocation were documented and rates of recurrence were compared. Pooled ORs were analysed using random-effects meta-analysis.Ten studies comprising 1324 participants met the criteria for inclusion. Recurrent instability following a first-time traumatic anterior shoulder dislocation was 39%. Increased risk of recurrent instability was reported in people aged 40 years and under (OR=13.46), in men (OR=3.18) and in people with hyperlaxity (OR=2.68). Decreased risk of recurrent instability was reported in people with a greater tuberosity fracture (OR=0.13). The rate of recurrent instability decreased as time from the initial dislocation increased. Other factors such as a bony Bankart lesion, nerve palsy and occupation influenced rates of recurrent instability.Sex, age at initial dislocation, time from initial dislocation, hyperlaxity and greater tuberosity fractures were key risk factors in at least two good quality cohort studies resulting in strong evidence as concluded in the GRADE criteria. Although bony Bankart lesions, Hill Sachs lesions, occupation, physiotherapy treatment and nerve palsy were risk factors for recurrent instability, the evidence was weak using the GRADE criteria-these findings relied on poorer quality studies or were inconsistent among studies.
Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease.
Authors: M Decramer, V de Bock, R Dom
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

The functional and histologic picture of steroid-induced myopathy was systematically examined in eight patients with chronic obstructive pulmonary disease (COPD) and compared with control patients with COPD matched for age, sex, and degree of airflow obstruction. Steroid-induced myopathy was associated with severe peripheral muscle weakness, quadriceps force being 23 +/- 14 versus 71 +/- 23% in control patients with COPD (p < 0.001). In addition, clear ventilatory muscle weakness was present. PImax was 37 +/- 15 versus 67 +/- 24% in control patients (p < 0.001 ), and PEmax averaged 34 +/- 10 versus 74 +/- 23% (p < 0.001). Vital capacity tended to be slightly reduced compared with that in control patients (69 +/- 21 versus 80 +/- 16%, p = 0.11). The only biochemical abnormalities associated to steroid-induced myopathy were a moderately increased lactic dehydrogenase level (697 +/- 301 versus 421 +/- 128 IU/L, p < 0.001) and an increased creatine excretion in 24-h urine (990 +/- 609 versus 159 +/- 219 mg/24 h, p< 0.001). On quadriceps biopsy steroid-induced myopathy was characterized by increased variation in diameter of fibers, with several angular atrophic fibers and diffuse necrotic and basophilic fibers. In addition, increased amount of connective tissue in between fibers and increased number of subsarcolemmal and central nuclei were present. On ATPase stain diffuse fiber atrophy predominantly affecting fast fibers was present, but there was no indication that atrophy was confined to type IIb fibers in contrast to conventional thinking. On follow-up, survival of patients with steroid-induced myopathy was reduced in comparison with control patients with COPD with similar degree of airflow obstruction (p < 0.025).
Pemphigus foliaceus with neutrophilic spongiosis evolving to an atypical pemphigus phenotype
Authors: Tatiana Villas Boas Gabbi, Isabela M. Bernardelli, Cláudia G. Santi, Celina W. Maruta, Vanessa Kodani, Mirian N. Sotto, Ning Li, Julio Hilario-Vargas, Luis A. Diaz, Evandro A. Rivitti, Valéria Aoki
Journal: Journal of the American Academy of Dermatology (2004)