tbuckley/cabot-search huggingface dataset:
The speckled epidermal nuclear immunofluorescence of mixed connective tissue disease seems to develop as an in vitro phenomenon
Authors: K. IWATSUKI, H. TAGAMI, S. IMAIZUMI, M. GINOZA, M. YAMADA
Journal: British Journal of Dermatology (1982)

The pathogenesis of speckled epidermal nuclear immunofluorescence in patients with mixed connective tissue disease (MCTD) was studied by reproducing this reaction in guinea-pigs, using serum samples containing high titre antibody to ribonucleoprotein (RNP). Immunofluorescence studies on specimens obtained from guinea-pig skin into which serum samples containing high titre RNP antibody had been injected intradermally, revealed positive epidermal nuclear staining for IgG. This speckled immunofluorescence was demonstrable immediately after injection and remained so for 24 or 48 h. The pattern of fluorescence was similar in all cases, and there was no penetration of RNP antibody through the cell membrane. The epidermal nuclear fluorescence was not detected with sera at a dilution of 1:100 or more. These results provide strong evidence that the epidermal nuclear immunofluorescence observed in patients with high titre antibody to RNP develops as an in vitro phenomenon.
A Randomized Clinical Trial of the Treatment Effects of Massage Compared to Relaxation Tape Recordings on Diffuse Long-Term Pain
Authors: Dan Hasson, Bengt Arnetz, Lena Jelveus, Bo Edelstam
Journal: Psychotherapy and Psychosomatics (2003)

&lt;i&gt;Background: &lt;/i&gt;Long-term musculoskeletal pain is a common problem in primary health care settings that is difficult to treat. Two common treatments are mental relaxation and massage. Scientific studies show contradictory results. Furthermore, many studies lack long-term follow-up even though it is a chronic disorder. The purpose of this randomized clinical trial was to assess possible effects of massage as compared to listening to relaxation tapes in conditions of ‘diffuse’ and long-term musculoskeletal pain. &lt;i&gt;Methods:&lt;/i&gt; 129 patients from primary health care suffering from long-term musculoskeletal pain were randomized to either a massage or mental relaxation group, and assessed before, during and after treatment. &lt;i&gt;Results:&lt;/i&gt; During treatment there was a significant improvement in the three main outcome measures: self-rated health, mental energy, and muscle pain only in the massage group as compared to the relaxation group. However, at the 3-month post-treatment follow-up, there was a significant worsening in the outcome measures (time × group effect p &lt; 0.05) back to initial rating levels in the massage group as compared to no changes in the relaxation group. &lt;i&gt;Conclusion:&lt;/i&gt; Massage, but not mental relaxation, is beneficial in attenuating diffuse musculoskeletal symptoms. Beneficial effects were registered only during treatment. This lack of long-term benefits could be due to the short treatment period or treatments such as these do not address the underlying causes of pain. Future studies of long-term pain should include longer treatment periods and post-treatment follow-up. It might also be worthwhile assessing the long-term benefits from booster treatment after the initial intense treatment period.
The Regulation of Growth and Intracellular Signaling by Integrins
Authors: JERE E. MEREDITH, SIM WINITZ, JEAN McARTHUR LEWIS, SIBYLLE HESS, XIANG-DONG REN, MARK W. RENSHAW, MARTIN ALEXANDER SCHWARTZ
Journal: Endocrine Reviews (1996)

INTEGRINS are a family of more than 20 different transmembrane receptors composed of noncovalently associated α- and β-subunit heterodimers (1). Twelve different α-subunits, each approximately 1000 residues in length, and eight different β-subunits, each approximately 750 residues, have been identified. The receptor consists of a very large extracellular domain, a transmembrane region, and a relatively short cytoplasmic region. The extracellular domain binds to various ligands including extracellular matrix (ECM) proteins, such as fibronectin (FN), vitronectin (VN), and collagen (Col), and to other cell surface receptors such as ICAM-1 (intercellular adhesion molecule) and VCAM-1 (vascular cell adhesion molecule). The receptor cytoplasmic domains interact with cytoskeletal proteins. In addition to their role as adhesion receptors, integrins also function as signaling receptors and have been shown to regulate reorganization of the cytoskeleton, intracellular ion transport, lipid metabolism, kinase activation, and gene expression. In this review we will discuss the diverse integrinmediated signals presently known, with emphasis on the integrin-mediated signals that regulate cell growth and survival. For a discussion of integrin-mediated regulation of cell migration, differentiation, and integrin-ligand binding, the reader is referred to other integrin reviews (2–6).
The Loch Ness Monster
Authors: G. G. Liddle
Journal: JAMA (1970)

Traveling southward from Dornoch, and branching off the coastal road toward Drumnadrochit, a turnout just beyond Castle Urquhart (Figure) offered a pleasant rest on the northern bank of Loch Ness. Having settled down to noon-day cheese, bread, and wine, a sibilant voice exclaimed, Ahem! a word rarely heard today even in Scotland. Unable to locate another person on the bank,  returned to my cheese only to see a large head regarding me from the Loch. It had cerulean blue irides estimated at 360 cm in diameter, and small fiery orange pupils. Below these magnificent orbs was a broad set of smiling lips of gentle and friendly mien, rather frog-like. Its nostrils reminded one of a hippopotamus, but the bewhiskered chin was of Chinese style.  Ahem,  rejoined, not so much in awe or apprehension as in respect.  You seem to be a likely bloke, said the lips. I hope
Admissions to hospital under the Mental Health Act rise by 30% over 10 years
Authors: Zosia Kmietowicz
Journal: BMJ (2004)

Mental health services in the United Kingdom are in crisis, with more people than ever being detained in hospital under compulsory orders, says a report.

Admissions to hospital under the Mental Health Act have risen by nearly 30% in the past decade in England, figures from the Department of Health show. According to a report from three national mental health charities, Rethink, Sane, and the Zito Trust, this figure is a sorrowful reflection of the current state of hospital care for people with psychiatric illness.

The report, Behind Closed Doors , says that …
Physicians, Vital Statistics, and Disease Reporting
Authors: Richard A. Goodman
Journal: JAMA (1987)

Why should physicians know how to complete death certificates? What diseases must be reported to health departments? While these questions may not titillate all readers ofThe Journal, the fact is that mortality and morbidity data provided by clinical practitioners serve as the foundation of essential databases used for planning, implementing, and evaluating health programs at all levels in the United States. As such, the role played by the practitioner in reporting health data has far-reaching effects on our nation's health programs. The medical literature has increasingly focused attention on the implications for accuracy in completing death certificates and other forms that are essential to meet the health information needs of the United States. For example, articles inThe Journaland other publications have recently addressed topics such as uses of multiple-cause-of-death data, reporting of congenital malformations, the imperative of documenting tobacco use—related mortality, surveillance for infectious diseases, and the
Primary health care in residential homes for the elderly.
Authors: K Morgan
Journal: BMJ (1982)

Elderly implies that the answers which may be produced by this large multinational, hospital-based trial will be no more clearcut than the ones we reported from our small single-centre trial.If so, we share the hopes of Professor W S Peart and his colleagues (p 1397) that a further "trial of antihypertensive treat- ment in people aged 65-74 may be mounted attempting to determine the balance between the benefits of pressure reduction and any adverse effects."
Leading scientists call for action against malaria
Authors: S. Swafford
Journal: BMJ (1997)

World leaders in science and health have called for urgent collaborative action against malaria, warning that a disaster looms over Africa.

“The international community has a responsibility to recognise malaria, like the AIDS pandemic, as a major challenge and to commit itself to do more to prevent the disaster that looms over Africa,” wrote the 18 scientists in a letter in Nature (1997;386:541). Signatories to the letter included …
Landing patterns in netball: analysis of an international game.
Authors: D Hopper, S K Lo, C Kirkham, B Elliott
Journal: British Journal of Sports Medicine (1992)

The passing and landing patterns among netball players were investigated by examining all the 595 passes in an international match between Australia and New Zealand. Intra-class correlations were used to test inter-observer reliability. The independence of two variables was tested using a Pearson chi 2 test and a contingency coefficient was used to assess the degree of association between variables. An inter-rater reliability in the identification of movement patterns was 0.99. Most of the landings observed in this match were on the forefoot and not the hindfoot as generally reported in controlled experiments. Only 14% of the players leapt to receive a pass compared with 76% reported earlier under controlled environments. The distribution of passing techniques unexpectedly showed that approximately 50% of all the players did not reach for the ball as it was thrown directly to them. However, over 70% of the players threw straight passes which were mainly received in the chest quadrant and other types of passes such as loop, bounce and rebound were used less frequently. Nearly 50% of all players used a right-handed pass to dispose of the ball, while the next most popular pass was to use both hands (40.2%). Landing and passing patterns differed between players in different positions. Footfall patterns on landing after a catch were associated with the trajectory of the ball.
Abnormal F-18 Fluoride Uptake in Intracranial Meningiomas on PET/CT
Authors: Thorsten Derlin, Janos Mester, Susanne Klutmann
Journal: Clinical Nuclear Medicine (2010)

The association between breast carcinoma and meningioma is a well-recognized phenomenon that may have important clinical implications, particularly in intracranial lesions. We report 2 cases of intracranial meningioma in adult women with a history of breast cancer, who were imaged with positron emission tomography/computed tomography (PET/CT) for evaluation of possible bone metastases. Whole-body F-18 fluoride PET demonstrated an intense intracranial focal radiotracer accumulation in both patients. Simultaneous CT showed a corresponding calcified space-occupying lesion, consistent with meningioma. Early and correct diagnosis of synchronous meningioma in F-18 fluoride bone scans might prevent relevant neurologic comorbidity.
Brown Tumor of the Orbit
Authors: Neri J. Holzer
Journal: JAMA (1977)

BROWN tumor arising in the retroorbital region has not, to our knowledge, been previously reported. We report the case of a woman with chronic renal failure and a rapidly progressive proptosis with loss of visual acuity secondary to orbital brown tumor. <h3>Report of a Case</h3> A 24-year-old woman receiving long-term hemodialysis, with a four-year history of renal failure secondary to glomerulonephritis, was admitted to Montefiore Hospital on July 30, 1976, complaining of rapidly progressive proptosis of the right eye (OD), right-sided headaches, decrease in visual acuity, and right facial numbness. She had a 12-mm proptosis of the right eye, with severe reduction in extraocular motion in all directions. Visual acuity was 20/70 OD, and 20/25 in the left eye. A Marcus-Gunn pupil was present in the right eye. Funduscopic examination showed striking choroidal folds in the posterior pole of the right eye. Hypesthesia was present in the right infraorbital nerve
Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model
Authors: W-H. Boehncke, F.R. Ochsendorf, S. Noll, M. Urban, A. Popp, D. Waldherr, J. Haunschild, T. Litzenburger
Journal: British Journal of Dermatology (2005)

Psoriasis is considered as a chronic immune-mediated disease characterized by inflammation and proliferation of the epidermis.Targeting intercellular adhesion molecule 1 (ICAM-1) is an attractive therapeutic option as this molecule is critically involved in leucocyte adhesion and extravasation as well as in lymphocyte activation.We have selected the fully human monoclonal antibody MOR102 (#5) against ICAM-1 from the Human Combinatorial Antibody Library (HuCAL). This antibody, as human IgG4 [corrected] was tested for its ability to interfere with lymphocyte activation and adhesion in vitro as well as for its antipsoriatic efficacy in vivo using the psoriasis-severe combined immunodeficient (SCID) mouse model.The antibody demonstrated efficient inhibition of lymphocyte adhesion to ICAM-1 in vitro, with an IC(50) of approximately 0.4 microg mL(-1) (3 nmol L(-1)). In addition, MOR102 (#5) reduced lymphocyte proliferation in mixed lymphocyte cultures by approximately 50%. The in vivo efficacy of MOR102 (#5) was tested on grafts derived from lesional skin of patients with chronic plaque-stage psoriasis transplanted on to SCID mice. Intraperitoneal injection of 10 mg kg(-1) of MOR102 (#5) antibody every alternate day over a period of 4 weeks resulted in reconstitution of orthokeratotic differentiation and a significant (P < 0.05) reduction in epidermal thickness as well as marked reduction in the inflammatory infiltrate. Therapeutic activity may be related to the targeting of ICAM-1 on keratinocytes and thus preventing efficient activation of local T cells.Based on the efficacy of the fully human monoclonal antibody MOR102 (#5) shown in vitro as well as in vivo in the psoriasis-SCID mouse model, initiation of clinical studies is indicated.
Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients
Authors: Seung-Hwan Lee, Shin-Ae Park, Seung-Hyun Ko, Hyeon-Woo Yim, Yu-Bae Ahn, Kun-Ho Yoon, Bong-Yun Cha, Ho-Young Son, Hyuk-Sang Kwon
Journal: Metabolism (2009)
Physicians With Georgia on Their Minds
Authors: Marsha F. Goldsmith
Journal: JAMA (1989)

INTERNAL UNREST may require the expertise of physicians other than gastroenterologists these days. Numerous countries are experiencing varied forms of political upheaval, some of which lead to injury and/or death among the population and subsequent medical investigation. Three American physicians who visited Soviet Georgia in midMay following nationalist demonstrations in Tbilisi, the capital city, have now recounted their experience. The American physicians who went to Georgia are Barry H. Rumack, MD, director of the Rocky Mountain Poison Center and professor of toxicology and of pediatrics at the University of Colorado Medical Center in Denver; Jennifer Leaning, MD, chief of emergency services at Harvard Community Health Plan and attending physician at Harvard Medical School's Brigham and Women's Hospital, Boston; and Ruth A. Barron, MD, assisting attending psychiatrist at McLean Hospital and a Harvard Medical School faculty member. At the request of Soviet physicist Andrei Sakharov and the invitation of health authorities
As I Was Dying: An Examination of Classic Literature and Dying
Authors: Roger C. Bone
Journal: Annals of Internal Medicine (1996)

On Being a Patient15 June 1996As I Was Dying: An Examination of Classic Literature and DyingRoger C. Bone, MDRoger C. Bone, MDMedical College of Ohio, Toledo, OH 43614Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-12-199606150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Medical training rarely deals with helping the dying patient find peace and comfort. In fact, most physicians are uncomfortable with the entire subject. I believe it is one of the most neglected aspects of medical care. I have spent my career as a pulmonary and critical care physician, and I have cared for thousands of dying patients. In many cases, both the patients and I knew that they were dying. After I provided clinical and supportive care, I would walk away from their bedside and go on with my work and go home to my family.Now the world has ... Author, Article, and Disclosure InformationAffiliations: Medical College of Ohio, Toledo, OH 43614Corresponding Author: Roger C. Bone, MD, Medical College of Ohio, 3000 Arlington Avenue, Toledl, OH 43614. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPedagogy of Mortality: A Concept in ProgressReflections of Physician-Authors on Death: Literary Selections Appropriate for Teaching RoundsHumanistic Qualities in End-of-Life Care: Lessons from The Diving Bell and the Butterfly: A Memoir of Life in Death —Required Reading in an End-of-Life Care Curriculum for Internal Medicine ResidentsBook review: Reflections: a guide to end of life issues for you and your familyFlawed research: Is it the design, methods, or the wrong conclusions? 15 June 1996Volume 124, Issue 12Page: 1091-1093KeywordsBoneEmotionsHappinessLungsMortalityMotivationRacial and ethnic issuesSleepSmellVision ePublished: 15 August 2000 Issue Published: 15 June 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cross-cultural adaptation of the VISA-P questionnaire for Greek-speaking patients with patellar tendinopathy
Authors: Vasileios Korakakis, Asterios Patsiaouras, Nikos Malliaropoulos
Journal: British Journal of Sports Medicine (2012)

Objectives To cross-culturally adapt the VISA-P questionnaire for Greek-speaking patients and evaluate its psychometric properties. Background The VISA-P was developed in the English language to evaluate patients with patellar tendinopathy. The validity and use of self-administered questionnaires in different language and cultural populations require a specific procedure in order to maintain their content validity. Methods The VISA-P questionnaire was translated and cross-culturally adapted according to specific guidelines. The validity and reliability were tested in 61 healthy recreational athletes, 64 athletes at risk from different sports, 32 patellar tendinopathy patients and 30 patients with other knee injuries. Participants completed the questionnaire at baseline and after 15–17 days. Results The questionnaire's face and content validity were judged as good by the expert committee, and the participants. Concurrent validity was almost perfect (ρ=−0.839, p&lt;0.001). Also, factorial validity testing revealed a two-factor solution, which explained 85.6% of the total variance. A one-factor solution explained 80.8% of the variance when the other knee injury group was excluded. Known group validity was demonstrated by significant differences between patients compared with the asymptomatic groups (p&lt;0.001). The VISA-P-GR exhibited very good test–retest reliability (ICC=0.818, p&lt;0.001; 95% CI 0.758 to 0.864) and internal consistency since Cronbach's α analysis ranged from α=0.785 to 0.784 following a 15–17 days interval. Conclusions The translated VISA-P-GR is a valid and reliable questionnaire and its psychometric properties are comparable with the original and adapted versions.
A Case of Charcot's Joint Disease, with Perforating Ulcer of the Foot in a Tabetic Patient
Authors: H. Waldo
Journal: BMJ (1894)

LumIclZ JOVARA. 1235 -&act that a tumour such a-above noted is developed.A full -account of these is given in J. Bland Sutton's recent work on Tumours.So large a tumour of the kind projecting into the #mouwdi is almost unknown.
Faster Radioiodine Washout in the Treatment of Pulmonary Metastases of Papillary Thyroid Cancer Prepared With Recombinant Human Thyroid-Stimulating Hormone
Authors: Guang-Uei Hung, Minglin Ho, Chia-Hung Kao
Journal: Clinical Nuclear Medicine (2009)

Although recombinant human thyroid-stimulating hormone (rhTSH) has been approved officially as an adjunct to the diagnostic approach of thyroid cancer and ablation of thyroid remnants, its application in treatment of persistent or metastatic disease is still under investigation. We present a 24-year-old woman with papillary thyroid cancer and bilateral lung metastases shown on the fist post-therapeutic scan, which was prepared with thyroid hormone withdrawal (THW). The second post-therapeutic scan prepared with rhTSH showed negative findings. The third post-therapeutic scan prepared with THW showed positive uptake in the lung metastases again. The serial findings indicate that the treatment of thyroid cancer prepared with rhTSH might result in a faster radioiodine washout in tumor foci than when prepared with THW.
Detention centres are bad for immigrant children's health, study finds
Authors: H. Mooney
Journal: BMJ (2009)

Prolonged detention in immigration centres seriously damages the physical and mental health and wellbeing of children, a new study has found.

The UK study shows clear evidence that detention is “harmful” to children. Doctors specialising in child health examined 24 children detained at Yarl’s Wood Immigration Removal Centre, near Bedford, and found that the majority were experiencing mental and physical health difficulties related to being in detention. Many of the children had come to the United Kingdom seeking asylum.

The doctors have called on the government to urgently re-examine its policy of keeping children detained in immigration centres after they found that children had developed depression and anxiety as well as physical problems relating to their detention. Their report, published in Child Abuse and Neglect (2009;33:573-85, doi:10.1016/j.chiabu.2008.10.005 …
COMPARATIVE HISTOLOGIC AND IMMUNOLOGIC STUDIES IN RABBITS OF INDUCED HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE
Authors: Frederick G. Germuth, Mary Geraldine Pace, Jack C. Tippett
Journal: The Journal of Experimental Medicine (1955)

Sensitization of rabbits with bovine albumin and the cross-reactive antigen, egg albumin, increased the rate of bovine albumin elimination following its intravenous administration. Elimination of this antigen was complete in 7 and 10 days respectively instead of approximately 2 weeks as in unsensitized normal animals. The peak incidence of allergic tissue alteration was proportionately accelerated. Certain qualitative and quantitative differences between the histologic responses of the sensitized and unsensitized rabbits were noted. These differences were probably due to the shorter period of antigen-antibody interaction in the sensitized animals in which the antigen was quickly eliminated. The temporal relationship between the histologic and immunologic responses in sensitized animals adds further support to the hypothesis that the lesions which occur after the injection of foreign protein are the result of antigen-antibody combination.