tbuckley/cabot-search huggingface dataset:
A New Reality
Authors: Scott A. Hardison
Journal: Annals of Internal Medicine (2012)

On Being a Doctor21 February 2012A New RealityScott A. Hardison, BSScott A. Hardison, BSFrom Wake Forest School of Medicine, Winston-Salem, NC 27104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-4-201202210-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Standing at 6 feet, 4 inches tall, I am easily spotted by my friends and colleagues in the daily rush of people moving through the hallways at the hospital. When you add my thin build and comically short white coat to the picture, I never exactly blend into the crowd. One day, near the beginning of my third year of medical school, I was standing in the lobby waiting for an elevator when a boy walked by, holding his mom's hand. He suddenly stopped dead in his tracks, pointed up at me, and said:“Look, Mommy! Tall!”“I've told you ... Author, Article, and Disclosure InformationAffiliations: From Wake Forest School of Medicine, Winston-Salem, NC 27104.Corresponding Author: Scott A. Hardison, BS; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 February 2012Volume 156, Issue 4Page: 319-320KeywordsBiopsyMotivationPainPelvisRunningSarcomaSleepSuicideSurgeryWheelchairs ePublished: 21 February 2012 Issue Published: 21 February 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Left Ventricular Hypertrophy Has a Greater Impact on Survival in Women Than in Men
Authors: Youlian Liao, Richard S. Cooper, George A. Mensah, Daniel L. McGee
Journal: Circulation (1995)

Background Echocardiographically determined left ventricular hypertrophy (LVH) has a well-demonstrated association with cardiovascular morbidity and mortality. However, whether or not there is a sex differential in the impact of LVH on mortality has never been systematically explored. Methods and Results This study enrolled 436 consecutive black patients (163 men and 273 women) free of angiographic coronary artery disease from a hospital registry. LVH (left ventricular [LV] mass/body surface area ≥117 g/m 2 in men and ≥104 g/m 2 in women) was present in 84 men (52%) and 119 women (44%). During a mean of 5 years’ follow-up (range, 0 to 9), 49 patients (26 men and 23 women) died. The mortality rate was 5.40 per 100 patient-years in men with LVH and 2.58 in men without LVH (crude relative risk [RR]=2.09) and 3.21 and 0.66, respectively, in women (RR=4.87). In Cox regression analysis, adjusting for age, hypertension, and ejection fraction, the RR of total death for LVH versus non-LVH was 2.0 (95% confidence interval [CI], 0.8 to 5.0) in men and 4.3 (95% CI, 1.6 to 11.7) in women. For cardiac death, RR was 1.3 (95% CI, 0.4 to 3.7) and 7.5 (95% CI, 1.6 to 33.8) in men and women, respectively. Analyses using LV mass indexed by height or height 2.7 with the use of different LVH cut points, comparing patients in the highest sex-specific tertile of mass index to those in the lower two tertiles, and the use of LV mass indexes as continuous variables similarly demonstrated a greater increase in risk of either fatal end point among women than men. Conclusions These findings indicate a sex difference in the contribution of LV mass and hypertrophy to mortality in the absence of coronary artery disease.
Evaluation of methods for quantitating left ventricular segmental wall motion in man using myocardial markers as a standard.
Authors: N B Ingels, G T Daughters, E B Stinson, E L Alderman
Journal: Circulation (1980)

Radiopaque markers were implanted in the left ventricular myocardial midwall in 58 patients and studied in the 30 degrees right anterior oblique projection by computer-aided fluoroscopy. Marker motion was used as a standard of segmental wall motion against which the accuracy of five methods for measuring left ventricular wall motion was assessed: two methods using hemiaxial measurements in rectangular coordinates, two using radial measurements in polar coordinates (all with frame-by-frame axial reindexing) and one using radial measurements in fixed external polar coordinates. The latter method showed significantly less error (25.9%, p less than 10(-6)) in measuring midwall marker motion than the other four methods (range 42.5--47.5%) in the group as a whole and in subgroups that had abnormalities of posterior, apical and anterior wall motion. This method also had the best correlation of marker motion and motion of adjacent endocardial border (of the overall left ventricle and the posterior, apical, and anterior walls separately) as visualized by ventriculography in 29 patients. The bulk of the reduction in error using this method was due to the use of a fixed external reference system, with a small additional increment of error removed by proper selection of the polar origin at a point 69% of the distance from the anterolateral edge of the aortic valve to the ventricular apex at end-systole.
Arthritis in psoriasis.
Authors: L Green, O L Meyers, W Gordon, B Briggs
Journal: Annals of the Rheumatic Diseases (1981)

A group of 61 unselected patients with psoriasis attending a dermatology clinic were studied to determine the prevalence of psoriatic arthritis. On defined criteria arthritis was present in 41.6%. Peripheral arthritis was present in 15.5%, and sacroiliitis in 43%. A strong association of distal interphalangeal arthritis with psoriasis and nail dystrophy was confirmed. Tissue typing showed a strong association of B23, 17, in Caucasoid psoriatics, while the haplotype A1/B8 was increased in mixed Caucasoid--Negroid psoriatics.
Listening to Leviticus
Authors: Bruce H. Campbell
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Major Depressive Disorder with Anger: A Bipolar Spectrum Disorder?
Authors: Franco Benazzi
Journal: Psychotherapy and Psychosomatics (2003)

Depression with anger may be more common in bipolar disorders. The aim of the study was to assess whether major depressive disorder (MDD) with anger could be included in the bipolar spectrum, by comparing it to MDD without anger and to bipolar II disorder.Consecutive outpatients (281 bipolar II disorder and 202 MDD) presenting for major depressive episode (MDE) treatment were interviewed with the DSM-IV structured clinical interview. Clinical variables used to support the inclusion of MDD with anger in the bipolar spectrum were age of onset, many MDE recurrences, atypical features of depression, depressive mixed state (an MDE plus some concurrent hypomanic symptoms), and bipolar family history.Frequency of MDE with anger was 50.5% [61.2% in bipolar II, and 35.6% in MDD (z = 5.5, p = 0.0000, 95% CI 16.8-43.3%)]. Logistic regression of MDE with anger (dependent variable) versus bipolar variables showed that MDE with anger was significantly associated with all bipolar variables, apart from recurrences. MDD with anger, compared with MDD without anger, had significantly lower age of onset, more marked depressive mixed state, a bipolar family history with more cases, but comparable atypical features and Global Assessment of Functioning scores. MDD with anger, compared with bipolar II disorder, had significantly higher age of onset, less atypical features, and a bipolar family history with less cases.MDE with anger was common in outpatients (more in bipolar II disorder). MDD with anger may be midway between MDD without anger and bipolar II disorder, and might be included into the bipolar spectrum. However, MDD with anger does not appear to be associated with the often reported negative response to monotherapy with antidepressants.
Safety and Efficacy of Subretinal Readministration of a Viral Vector in Large Animals to Treat Congenital Blindness
Authors: Defne Amado, Federico Mingozzi, Daniel Hui, Jeannette L. Bennicelli, Zhangyong Wei, Yifeng Chen, Erin Bote, Rebecca L. Grant, Jeffrey A. Golden, Kristina Narfstrom, Nasreen A. Syed, Stephen E. Orlin, Katherine A. High, Albert M. Maguire, Jean Bennett
Journal: Science Translational Medicine (2010)

After successful gene therapy to correct retinal degeneration in one eye, treatment of the second eye is safe and effective—even when immunity to the vector is present—in nonhuman primates and dogs.
THE CARCINOGENIC EFFECT OF A PAPILLOMA VIRUS ON THE TARRED SKIN OF RABBITS
Authors: Peyton Rous, John G. Kidd
Journal: The Journal of Experimental Medicine (1938)

The Shope papilloma virus elicits carcinomas forthwith, as well as papillomas in great variety, when it is distributed by way of the blood stream to the tarred epidermis of domestic rabbits. The phenomenon will be analyzed in succeeding papers with the aid of additional instances.
Cancer in an African Community, 1897-1956
Authors: J. N. P. Davies, S. Elmes, M. S. R. Hutt, L. A. R. Mtimavalye, R. Owor, L. Shaper
Journal: BMJ (1964)

In recent years it has become evident that the African population of Uganda has a very different pattern of site and type frequencies of cancer from that which obtains in Europe and North America.This has been established in the last decade, and it is of interest to establish if this is a stable pattern, if it has remained similar over a period of time, and if there is evidence of change in the pattern in view of the development of Uganda under Western modernizing influences.This bears directly on the long controversy of whether " cancer is a disease of civilization " or that cancer is a rare disease of " primitive" peoples.rhough the fallacies of the belief that cancer is a rare disease of primitive peoples have long been exposed (Willis, 1960) it still lingers in some quarters (Schweitzer; see Berglas, 1957), having been widely propagated by Hoffman (1915) and to some extent supported by des Ligneris (1927Ligneris ( , 1936)).Both these authors used the low ratio of cancer to total hospital admissions to support this thesis.Table I is modified from des Ligneris (1936) to show examples of such low ratios.It is of interest that more recent information from the Transvaal region (Higginson and Oettl6, 1960) has shown that overall cancer
[336] THE ANTIFIBROTIC EFFECT OF MYCOPHENOLATE MOFETIL IS LOST AT CLINICALLY RELEVANT DOSE, FOLLOWING A BIPHASIC DOSE-DEPENDENT PATTERN IN LIVER FIBROSIS
Authors: Y. Popov, G. Millonig, A. Khokhar, J. Zaks, K.R. Bhaskar, D. Sverdlov, D. Schuppan
Journal: Journal of Hepatology (2007)
The Follicle-Stimulating Hormone Receptor: Biochemistry, Molecular Biology, Physiology, and Pathophysiology*
Authors: Manuela Simoni, Jörg Gromoll, Eberhard Nieschlag
Journal: Endocrine Reviews (1997)

I. Introduction II.Biochemical Properties of the FSH Receptor: A Historical Prelude III.Molecular Structure of the FSH Receptor A. Cloning of the FSH receptor B. Predicted primary structure of the FSH receptor C. Molecular mass of the FSH receptor IV.The FSH Receptor Gene A. Chromosomal localization B. Structure and organization of the FSH receptor gene C.The promoter of the FSH receptor gene V. Expression of the FSH Receptor and Its Regulation A. FSH receptor gene expression B. Expression of the FSH receptor in the testis C. Expression of the FSH receptor in the ovary VI.Expression of the FSH Receptor in Cell Lines A. Cell lines expressing the recombinant FSH receptor B
Acute effects of summer air pollution on respiratory health of asthmatic children.
Authors: M H Gielen, S C van der Zee, J H van Wijnen, C J van Steen, B Brunekreef
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

In the early summer of 1995, the acute respiratory effects of ambient air pollution were studied in a panel of 61 children, ages 7 to 13 yr, of whom 77% were taking asthma medication. Peak flow was measured twice daily with MiniWright meters at home and the occurrence of acute respiratory symptoms and medication use was registered daily by the parents in a diary. Exposure to air pollution was characterized by the ambient concentrations of ozone, PM10, and black smoke. During the study period, maximal 1-h ozone concentrations never exceeded 130 microg/m3, and 24-h black smoke and PM10 concentrations were never higher than 41 and 60 microg/m3 respectively. Associations of air pollution and health outcomes were evaluated using time series analysis. After adjusting for pollen, time trend, and day of the week, black smoke in particular was associated with acute respiratory symptoms and with medication use. Less strong associations were found for PM10 and ozone. These results suggest that in this panel of children, most of whom had asthma, relatively low levels of particulate matter and ozone in ambient air are able to increase symptoms and medication use.
Validity of the 133Xenon Method for Determination of Muscle Blood Flow in Man as Evaluated by Simultaneous Venous Occlusion Plethysmography during Intravenous Infusions of Adrenaline
Authors: H. Barcroft, M. Briggs, T. M. D. Gimlette, A. Nasrallah
Journal: Cardiovascular Research (1967)

Intravenous infusions of adrenaline (10 μg/min) were accompanied by a transient increase in blood flow both in the forearm and calf (plethysmograph) and in the brachioradialis and gastrocnemius muscles (133Xenon clearance). The results confirm the view that the 133Xenon method is useful for determining changes in skeletal muscle blood flow.
Diffuse cutaneous mastocytosis
Authors: A.H. Willigen, A.P. Oranje
Journal: British Journal of Dermatology (1990)

FIGURE I. Cutaneous T-ceil lymphoma after successful treatment of follicular B-ceil lymphoma.1983.IgH gene analysis showed a monoclonal B-cell population in the lymph-node biopsy of 1983 but not in the 1988 skin biopsy.Comment.The disorder was diagnosed as a cutaneous T-cell lymphoma and developed in a patient who was successfully treated for a follicular B-cell lymphoma.The occurrence of two malignancies in one patient can be explained by a high susceptibility for lymphoma, or the development of a second lymphoma may have been due to previous treatment with cytostatic drugs.
Expression of programmed death‐1 in skin biopsies of benign inflammatory vs. lymphomatous erythroderma
Authors: F. Çetinözman, P.M. Jansen, R. Willemze
Journal: British Journal of Dermatology (2014)

Histological differentiation between Sézary syndrome (SS) and erythrodermic inflammatory dermatoses (EID) can be very difficult. Recent studies show that programmed death-1 (PD-1) is strongly expressed by the neoplastic cells in skin biopsies of SS, while similar studies in EID are lacking.To determine whether the number and distribution of PD-1(+) T cells could be used as an adjunct in the differentiation between SS and EID.Expression of PD-1 and a panel of T-cell markers was investigated in skin biopsies from 30 patients with various types of EID (12 idiopathic, 10 atopic, six psoriatic and two paraneoplastic) and 25 patients with SS.Expression of PD-1 by > 50% of the infiltrating T cells was observed in 23 of 25 (92%) SS cases and in only four of 30 (13%) EID cases. PD-1 is expressed by neoplastic CD4(+) T cells in SS, while in contrast, PD-1 was predominantly expressed by dermal and epidermal CD8(+) T cells in EID. Expression of CD7 by ≤ 20% of the infiltrating T cells was observed only in SS (13 of 24; 54%), and not in any of the 30 cases of EID.While PD-1 is expressed by CD4(+) neoplastic T cells in SS, our results suggest that PD-1 is expressed mainly by activated dermal and epidermal CD8(+) T cells in EID. Expression of PD-1 by > 50% of CD4(+) T cells and expression of CD7 by ≤ 20% of the infiltrating T cells strongly support a diagnosis of SS in skin biopsies of patients with erythroderma.
CONCERNING ADENOMATA ORIGINATING FROM THE ISLANDS OF LANGERHANS
Authors: Russell L. Cecil
Journal: The Journal of Experimental Medicine (1911)

Small encapsulated tumors of the size of peas, or even smaller, are occasionally found in the pancreas. These tumors are benign, and have a structure similar in all respects to that of an hypertrophied island of Langerhans. The distinctions between adenomata and forms of regenerative hypertrophy, sometimes so difficult to make in the breast, prostate, liver, and other organs, is not easily drawn in the present case. The fact that one may encounter all gradations in the size of islands, from that of the normal island to that of the tumors, suggests that it is more reasonable to consider such tumors merely as hypertrophied islands rather than as adenomata originating from islands.
Treatment of Chronic Furunculosis
Authors: L. G. Tulloch, V. G. Alder, W. A. Gillespie
Journal: BMJ (1960)

deserves special comment.This disease is a primary degeneration of the neuro-epithelium of the retina on a hereditary basis, the importance of blood relationship among parents for the manifestation of the disease having been established (Nettleship, 1907-8).Cataracts often complicate retinitis pigmentosa and are always present in cases of Werner's syndrome.If we accept the view that retinitis pigmentosa belongs to a group of hereditary diseases which have this in common, that the cells and tissues affected become prematurely senile (Verhoeff, 1931), then retinitis pigmentosa and the cataracts, common to the two diseases, are further evidence that Werner's syndrome is a heredo-degenerative disease of unknown origin.(It will be noted that our patient's parents were first cousins.)From the foregoing it would appear that premature senile changes, rather than endocrinopathies, offer the best explanation for the functional and structural changes described in Werner's syndrome. SummaryThe clinical and post-mortem findings in a case of Werner's syndrome with uraemia and hypertension are described.The renal failure was found to be due to vascular contracted kidneys and arteriosclerotic occlusion of the right renal artery.The presence of retinitis pigmentosa in Werner's syndrome is an interesting finding which, together with other evidence, points to a heredo-degenerative disease in widely distributed body cells and tissues, affected by inherent characteristics which result in their degeneration.
Wilma Elizabeth Gemmell
Authors: Catriona MacRae, Catriona McHugh
Journal: BMJ (2007)

Exchanging each of the conserved aromatic residues of the NPxxY(x)<sub>5,6</sub>F sequence (at the boundary of helices 7 and 8) generated variants of the A<sub>1</sub> adenosine receptor that were retained within the cell. The mutations disconnected a link between α-helix 7 and cytosolic helix 8, likely destabilizing the structure of the proximal carboxyterminus. The mutant receptors were rescued by incubation of cells with a pharmacochaperon, a membrane-permeable ligand that homosterically binds to the receptor; pharmacochaperoning restored the density of functional receptors at the plasma membrane. The following observations support the assumption that retention - and the site of pharmacochaperon action - was within bounds of the endoplasmic reticulum (ER). (i) The retained receptor co-localized with an ER marker; (ii) pharmacochaperoning initiated receptor transfer to Golgi stacks; (iii) the inhibitor of glycoprotein synthesis tunicamycin suppressed receptor chaperoning. Our data are consistent with the hypothesis that pharmacochaperoning stabilizes the structure of late folding intermediates and lifts a block on maturation allowing the receptors to exit from the ER. We suggest that the ER-associated Hsp40 (heat-shock protein) family member DRiP78 (D<sub>1</sub>-receptor interacting protein, <i>M<sub>r</sub></i>~78×10<sup>3</sup>) represents a model executor of quality control. Overexpressed DRiP78 interacted physically with the A<sub>1</sub>-receptor, inhibited export to the plasma membrane and in this action was selective for the mutants relative to the wild-type receptor. Both agonist and antagonist were effective chaperon ligands. Thus, occupancy of the binding pocket corrected the mutation-induced disorder indicating a mutual impingement of the transmembrane domain and the proximal carboxyterminus in establishing the stable receptor fold.
Dark Paradise: Opiate Addiction in America Before 1940
Authors: Peter L. Putnam
Journal: JAMA (1982)

For anyone willing to read through the enormous amount of information, this book can be a fascinating experience. It details the transition from the medical addict of the early 19th century—middle-class, usually female, and usually respectable—to the hustling mainline junkie we know today.  From an era of genteel tolerance to one of prohibition, the author-historian has done a careful, painstaking job of collecting information; nearly half the book consists of notes and bibliography. He shows a limited understanding of epidemiology principles both in the use of data and in inference, rarely distinguishing between incidence and prevalence or among point, period, and lifetime prevalence. He takes an advocate's approach to history, lacking in some ways the sensitivity of the social scientist or clinician. His exposition lacks modern theoretical insights into substance abuse, ignoring most if not all recent clinical and experimental studies of addiction.  The author is most interesting as a
Attitudes and Perceptions of School-Aged Children Toward Alopecia Areata
Authors: Andrew Hankinson, Heidi McMillan, Jeffery Miller
Journal: JAMA Dermatology (2013)

Although not life-threatening, alopecia areata (AA) is associated with increased rates of depressive symptoms and anxiety in children.1 This study investigates how schoolchildren, from kindergarten (K) through grade 8, perceive those with AA and the associated social ramifications.
Not Forgetting Forgetting
Authors: Judy Illes
Journal: The American Journal of Bioethics (2007)

"Not Forgetting Forgetting." , 7(9), pp. 1–2 Acknowledgment: The author wishes to acknowledge the thoughtful comments of Edith Wolf, Esq., members of the Women's Bioethics Project (WBP) in Seattle, WA during the March 2007 WPB meeting, and members of the audience at the Stanford University screening and panel discussion of Eternal Sunshine of the Spotless Mind during Brain Awareness Week, March 2007. Many thanks also to Fabrice Jotterand and Emily Murphy for valuable conversations and input.
A DOG WHO CHANGED MY PRACTICE, FOR A WHILE
Authors: A. Landers
Journal: BMJ (1996)

“Ben's coughing up blood,” I called to my father as I wiped his lips with my napkin and stroked his back. My father's golden retriever is 11 years old and my father's life is regulated by Ben's bowels, his walks, his likes, and his dislikes.

Ben had developed mild heart failure, plus a possible chest infection earlier in the week and had been prescribed bronchodilators and antibiotics. During the week he had been slightly short of breath, lacking in energy, and his exercise tolerance was low. He had also developed a cough, and this had become worse during the course of the day on which he was coughing up blood over dinner. We rang …