tbuckley/cabot-search huggingface dataset:
Gonadotropins Activate Proteolysis and Increase Invasion through Protein Kinase A and Phosphatidylinositol 3-Kinase Pathways in Human Epithelial Ovarian Cancer Cells
Authors: Jung-Hye Choi, Kyung-Chul Choi, Nelly Auersperg, Peter C.K. Leung
Journal: Cancer Research (2006)

Abstract Despite evidence that gonadotropins may facilitate peritoneal metastasis of ovarian cancer by increasing cell adhesion, the action and molecular mechanism of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in ovarian cancer invasion is not well characterized. In the present study, we investigated the effects of FSH and LH on the invasive activity and the expression of metastasis-related proteinases in human epithelial ovarian cancer by Western blot, zymography, reverse transcription-PCR (RT-PCR), ELISA, and Boyden chamber assay. Treatment with FSH or LH (10, 100, or 1,000 ng/mL) significantly increased the invasion of ovarian cancer cell lines, including BG-1, CaOV-3, and SKOV-3 cells but not OVCAR-3 cells. In addition, treatment of SKOV-3 cells with FSH or LH (100 or 1,000 ng/mL) enhanced the expression and activation of matrix metalloproteinases (MMP-2 and MMP-9) as shown by RT-PCR, gelatin zymography, and ELISA. Pretreatment with [(2R)-2-(hydroxamido-carbonylmethyl)-4-methylpentanoyl]-l-tryptophan methylamide (10 μmol/L), a total MMP inhibitor, and 3-(4-phenoxyphenylsulfonyl)-propylthiirane (20 μmol/L), a specific gelatinase inhibitor, neutralized the proinvasive effect of gonadotropins in SKOV-3 cells. In addition, the secretion of tissue inhibitor of metalloproteinases (TIMP-1 and TIMP-2) and plasminogen activator inhibitor-1 was significantly decreased by FSH and LH (100 or 1,000 ng/mL). We further showed that gonadotropins induced an increase in SKOV-3 invasiveness via the activation of protein kinase A (PKA) and phosphatidylinositol 3-kinase (PI3K) signaling pathways. Taken together, these results suggest that gonadotropins may contribute to ovarian cancer metastasis via activation of proteolysis and increase in invasion through the PKA and PI3K pathways. (Cancer Res 2006; 66(7): 3912-20)
Sulphinpyrazone and warfarin after myocardial infarction.
Authors: J A Tulloch, T C Marr
Journal: BMJ (1979)

days after the onset of symptoms showed a large, superficial ulcer in the mid-oesophagus.She responded well to withdrawal of emepronium bromide and to oral analgesics and nine days later repeat oesophagoscopy showed that the ulcer had healed.There have been a number of reports of oesophageal ulceration with emepronium bromide,'-4 as well as a report of mouth ulcers,; thought to be caused by prolonged contact of the tablet with the mucosa.The data sheet on this drug now suggests that the tablets should be swallowed with a glass of water, but it is apparent that this instruction is not always stressed by the doctor or followed by the patient.The tablet is formulated to distintegrate rapidly on contact with water but its hygroscopic nature can cause it to stick to the oesophageal mucosa if it is swallowed with too little water.Perhaps the time has come for the manufacturers to redevelop the presen- tation of this drug.Surely it will not be long before oesophageal perforation due to emepronium bromide is recorded.
Alcohol and Fatal Injuries Among US Adults
Authors: Robert F. Anda
Journal: JAMA (1988)

Use of alcohol is an important risk factor for fatal injuries. However, little information on the relationship between self-reported alcohol use and subsequent risk of fatal injury is available. Therefore, we examined the relationship between the usual number of drinks consumed per occasion and the incidence of fatal injuries in a cohort of US adults. Using data on self-reported alcohol use obtained from 13,251 adults who were included in the National Health and Nutrition Examination Survey Epidemiologic Follow-up Study (mean length of follow-up, 9.3 years), we calculated the incidence of fatal injury according to the usual number of drinks consumed per occasion. After we adjusted for the effects of age, sex, race, and education, persons who consumed five or more drinks per occasion were nearly twice as likely to die from injuries (relative risk, 1.9; 95% confidence interval, 1.0 to 3.5) than persons who drank fewer than five drinks per occasion. A dose-response relationship was observed between the usual number of drinks consumed per occasion and risk of fatal injury, with persons who reported drinking nine or more drinks per occasion being 3.3 times more likely to die from injuries (95% confidence interval, 1.3 to 8.3). These data demonstrate the impact of alcohol use on mortality from injuries in the United States and suggest that self-reported alcohol consumption is an important indicator of risk for fatal injury.
Detection of Heart Disease in Children 1919-1967
Authors: LEO M. HENIKOFF, WILLIAM A. STEVENS, LOWELL W. PERRY
Journal: Circulation (1968)

Since 1959, auscultation by physicians in screening 49,496 school children has yielded 4.5 cases of heart disease/1,000 students screened. Sensitivity by analysis of "inserted" cases averages 64%, but varies with capabilities of examining physicians. X-ray and ECG evaluations on smaller populations have yielded, respectively, 2.7 and 2.8 cases/1,000 children screened, and sensitivity results average 30 to 40%. The tape-recorded heart sounds technique has yielded 2.9 cases/1,000 in screening 188,925 children. Sensitivity by analysis of "inserted" cases averages 75% and, in the population of "naturally occurring" heart disease, 56%. In 23,148 school children, an analog-digital device (PhonoCardioScan) has yielded 4.8 cases/1,000 children screened. Of "inserted" cases, 69% have been detected. Sixtyfour to 80% of "naturally occurring" cases have been detected. With each technique, approximately 40% of the heart disease detected had been previously unknown. The specificity of these methods ranges from 95 to 99%. For primary screening the analog-digital device is the most effective currently available alternative to examination by cardiologists.
684 EFFECTS OF CHEMICAL MOIETIES AND POLYMORPHISMS IN THE HUMAN ABC TRANSPORTER ABCB1 (P-GLYCOPROTEIN/MDR1) IN DRUG-INDUCED LIVER INJURY
Authors: E. Ulzurrun, E. Crespo, F. Ruiz-Cabello, C. Stephens, Y. Borraz, M. Robles, M.R. Cabello, M.C. Fernández, G. Pelaez, M. Romero-Gómez, J.M. Navarro, R. Planas, J.F. Salmerón, C. Guarner, A. Castiella, M.I. Lucena, R.J. Andrade
Journal: Journal of Hepatology (2011)
Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles
Authors: Xiuying Li, Shiyan Guo, Chunliu Zhu, Quanlei Zhu, Yong Gan, Jukka Rantanen, Ulrik Lytt Rahbek, Lars Hovgaard, Mingshi Yang
Journal: Biomaterials (2013)
NON-INVASIVE INVESTIGATION OF CEREBRAL METABOLISM IN NEWBORN INFANTS BY PHOSPHORUS NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Authors: E.B. Cady, M. Joan Dawson, P.L. Hope, P.S. Tofts, A.M. De L. Costello, D.T. Delpy, E.O.R. Reynolds, D.R. Wilkie
Journal: The Lancet (1983)
Thymus cell antigen-1-expressing cells in the oval cell compartment
Authors: Mladen I. Yovchev, Jialin Zhang, David S. Neufeld, Petar N. Grozdanov, Mariana D. Dabeva
Journal: Hepatology (2009)

Thymus cell antigen-1 (Thy-1)-expressing cells proliferate in the liver during oval cell (OC)-mediated liver regeneration. We characterized these cells in normal liver, in carbon tetrachloride-injured liver, and in several models of OC activation. The gene expression analyses were performed using reverse-transcriptase polymerase chain reaction (RT-PCR), quantitative RT-PCR (Q-RT-PCR) of cells isolated by fluorescence-activated cell sorting (FACS), and by immunofluorescent microscopy of tissue sections and isolated cells. In normal liver, Thy-1(+) cells are a heterogeneous population: those located in the periportal region do not coexpress desmin or alpha smooth muscle actin (alpha-SMA). The majority of Thy-1(+) cells located at the lobular interface and in the parenchyma coexpress desmin but not alpha-SMA, i.e., they are not resident myofibroblasts. Although Thy-1(+) cells proliferate moderately after carbon tetrachloride injury, in all models of OC-mediated liver regeneration they proliferate quickly and expand significantly and disappear from the liver when the OC response subsides. Activated Thy-1(+) cells do not express OC genes but they express genes known to be expressed in mesenchymal stem cells (CD105, CD73, CD29), genes considered specific for activated stellate cells (desmin, collagen I-a2, Mmp2, Mmp14) and myofibroblasts (alpha-SMA, fibulin-2), as well as growth factors and cytokines (Hgf, Tweak, IL-1b, IL-6, IL-15) that can affect OC growth. Activated in vitro stellate cells do not express Thy-1. Subcloning of Thy-1(+) cells from OC-activated livers yield Thy-1(+) fibroblastic cells and a population of E-cadherin(+) mesenchymal cells that gradually discontinue expression of Thy-1 and begin to express cytokeratins. However, upon transplantation these cells do not differentiate into hepatocytes or cholangiocytes. Activated Thy-1(+) cells produce predominantly latent transforming growth factor beta.Thy-1(+) cells in the OC niche are activated mesenchymal-epithelial cells that are distinct from resident stellate cells, myofibroblasts, and oval cells.
Improving Results of Esophageal Stenting: A Study on 160 Consecutive Unselected Patients
Authors: A. Segalin, L. Bonavina, A. Carazzone, C. Ceriani, A. Peracchia
Journal: Endoscopy (1997)

Esophageal stenting is a valuable treatment in the management of malignant dysphagia. Recently, self-expanding stents have proved effective in reducing morbidity and mortality. The aim of this study was to evaluate the early and late results of esophageal stenting in a series of 160 consecutive unselected patients with unresectable esophageal and cardial carcinoma treated between November 1992 and December 1996.The procedure was successful in 159 patients (99.4%). A traditional tube was employed in 84 patients (52.5%). Metallic self-expanding stents have been available since June 1993 and were used in 75 selected patients (46.9%). The tumor was located in the cervical, upper, middle and lower thoracic esophagus, and at the gastric cardia in 16, 16, 56, 22 and 34 patients, respectively. In the remaining 15 patients an esophagovisceral anastomosis was involved. Preoperative chemo- and/or radiotherapy were performed in 82 patients (51.3%).Overall hospital morbidity was 11.3% (18/159) and included four dislodgments, four incomplete expansions of a self-expanding stent, two perforations, two incomplete sealings of a malignant respiratory tract fistula, two hemorrhages, two persistent foreign body sensations, one arrhythmia and one aspiration pneumonia. Hospital mortality was 1.3% (2/159) and was recorded in patients who underwent traditional intubation. At discharge, dysphagia was improved at least 2 degrees in 152 patients (96.8%). The overall long-term morbidity was 23.5% (37/157). Mean survival after the procedure was 4.7 months.Intubation is a safe palliative procedure which can be performed with low morbidity and mortality rates. Self-expanding metallic stents have enhanced the indications and the outcomes of the procedure, resulting in the treatment of strictures where the placement of a traditional tube is difficult or technically impossible.
927 HEMOADSORPTION OF HIGH-MOBILITY GROUP BOX 1 IN SWINE ACUTE LIVER FAILURE MODEL
Authors: R. Nishiyama, M. Shinoda, M. Tanabe, G. Oshima, K. Takano, Y. Fuchimoto, T. Miyasho, S. Yamada, K. Suda, K. Fukunaga, H. Takeuchi, S. Kawachi, Y. Morikawa, I. Maruyama, Y. Kitagawa
Journal: Journal of Hepatology (2011)
Abstract 5573: Nuclear IGF-1R expression as a prognostic factor in cervical cancer patients
Authors: Maki Tanioka, Tamotsu Sudo, Chiho Obayashi, Koji Matsumoto, Kiyoshi Fujiwara, Shunichi Negoro, Hironobu Minami
Journal: Cancer Research (2012)

Abstract Background: Insulin-like growth factor-1 receptor (IGF-1R) is an unusual transmembrane receptor in that both α and β subunits, regulated by IGF-1, translocate from the membrane to the nucleus and then bind to DNA, increasing gene transcription. Insulin receptor substrate-1 (IRS-1), a docking protein for IGF-1R, also traffics to the nucleus and then activates promoters of cell cycle progression genes. We studied the prognostic significance of nuclear and membranous IGF-1R and nuclear IRS-1 in cervical cancer, previously unreported. Methods: We retrospectively reviewed all patients (pts) with stage Ib2-IIb disease who received platinum-based neoadjuvant chemotherapy (NAC) at Hyogo Cancer Center between 2002 and 2009. Age, performance status, FIGO stage, histology, tumor size, pelvic lymph nodes on MRI, squamous cell carcinoma (SCC) antigen level, hemoglobin levels before NAC, chemotherapeutic agents and chemotherapy cycles were evaluated. Paraffin-embedded pretreatment tissue was stained immunohistochemically with an anti-IGF-1Rβ (Cell signaling, MA) or anti-IRS-1 (Millipore, MA) rabbit polyclonal antibody. IGF-1R and IRS-1 expressions were scored from 0 to 3 according to frequency and intensity. All slides were reviewed by a single pathologist. We analyzed prognostic factors associated with overall survival by a Cox proportional-hazards model. Results: A total of 128 pts (median age 57 years) were identified. The majority had stage II (61%) and SCC (69%). Median tumor size was 40 mm. Overall response rate to NAC was 59%, and median follow-up was 34 months. Nuclear and membranous IGF-1R and nuclear IRS-1 expressions were scored as 0/1-2/3 in 49/60/19 pts, 97/12/19 pts, and 65/41/22 pts, respectively. Multivariate analysis revealed that nuclear IGF-1R expression (HR, 2.6; P= .035 for score 1-3 vs. 0) and age &amp;lt;40 (HR, 2.6; P= .026) were independently associated with worse overall survival. Neither membranous IGF-1R nor IRS-1 expression had a prognostic impact on survival. Conclusions: Nuclear IGF-1R is commonly expressed in cervical cancer and is an independent prognostic factor, unlike membranous IGF-1R or nuclear IRS-1. Approaches that block the translocation of IGF-1R from the cell membrane to nucleus might hold promise for the treatment of cervical cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5573. doi:1538-7445.AM2012-5573
Low–Glycemic Index vs High–Cereal Fiber Diet in Type 2 Diabetes
Authors: Martin O. Weickert
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Superior antibacterial action and reduced incidence of bacterial resistance in minocycline compared to tetracycline-treated acne patients
Authors: E. ANNE EADY, J.H. COVE, K.T. HOLLAND, W.J. CUNLIFFE
Journal: British Journal of Dermatology (1990)

Journal Article Superior antibacterial action and reduced incidence of bacterial resistance in minocycline compared to tetracycline‐treated acne patients Get access E. ANNE EADY, E. ANNE EADY Department of Microbiology, University of Leeds LeedsGeneral Infirmary, Leeds, U.K. Dr E.Anne Eady, Department of Microbiology, University of Leeds, Leeds LS2 9JT, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.H. COVE, J.H. COVE Department of Microbiology, University of Leeds LeedsGeneral Infirmary, Leeds, U.K. Search for other works by this author on: Oxford Academic Google Scholar K.T. HOLLAND, K.T. HOLLAND Department of Microbiology, University of Leeds LeedsGeneral Infirmary, Leeds, U.K. Search for other works by this author on: Oxford Academic Google Scholar W.J. CUNLIFFE W.J. CUNLIFFE Department of Dermatology, Leeds General Infirmary, Leeds, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue 2, 1 February 1990, Pages 233–244, https://doi.org/10.1111/j.1365-2133.1990.tb08270.x Published: 01 February 1990
TLR-Independent Type I Interferon Induction in Response to an Extracellular Bacterial Pathogen via Intracellular Recognition of Its DNA
Authors: Marie Charrel-Dennis, Eicke Latz, Kristen A. Halmen, Patrick Trieu-Cuot, Katherine A. Fitzgerald, Dennis L. Kasper, Douglas T. Golenbock
Journal: Cell Host & Microbe (2008)
PREDICTORS OF DEATH IN TYPE B ACUTE AORTIC DISSECTION PATIENTS: AN ANALYSIS FROM THE INTERNATIONAL REGISTRY OF ACUTE AORTIC DISSECTION (IRAD)
Authors: William T. Froehlich, Jip L. Tolenaar, Toru Suzuki, Artur Evangelista Masip, Alan Braverman, Linda Pape, Matthias Voehringer, Patrick O'Gara, Alberto Forteza, Kevin Greason, Philippe Steg, Eric Isselbacher, Christoph Nienaber, Kim Eagle, Santi Trimarchi
Journal: Journal of the American College of Cardiology (2013)
Representativeness of samples from general practice lists in epidemiological studies: case-control study
Authors: A G Smith, N T Fear, G R Law, E Roman
Journal: BMJ (2004)

Ethical constraints often prevent epidemiological studies from evaluating the impact of non-participation.Particular problems may arise when subjects fail to respond to an approach by researchers or when they cannot be contacted because of inaccurate contact details or a doctor's refusal to give permission for their patient to be approached.If these subjects differ from those subjects who agree or decline to participate then the validity and generalisability of the study may be compromised.We investigated these issues in a case-control study of acute leukaemia in England.
Management of sleep apnoea syndrome
Authors: G Liistro, G Aubert, DO Rodenstein
Journal: European Respiratory Journal (1995)

Obstructive sleep apnoea is a chronic condition characterized by repetitive episodes of upper airway collapse during sleep, leading to sleep fragmentation. The management of sleep apnoea consists of general and specific measures. General measures should include weight loss in overweight patients; avoidance of alcohol during the evening hours; avoidance of any hypnotic drug. Specific measures may range from simple position training in patients with positional sleep apnoea (sleep apnoea appearing only when lying on the back) of slight severity; to oral appliances with the aim of creating a prognathism during sleep, to the introduction of a nasopharyngeal tube during sleep every night. When position training, oral appliances or a nasopharyngeal tube are used, their effect should be monitored by full night polysomnography. The best specific treatment for sleep apnoea is nasal continuous positive airway pressure. The main problem with nasal continuous positive airway pressure is the long-term compliance which should be assessed regularly over the years. In cases where nasal continuous positive airway pressure is not tolerated or compliance is bad, a surgical treatment can be proposed. Uvulopalatopharyngoplasty seems to give disappointing results. By contrast, maxillomandibular surgery is credited with the best results available as far as surgery is concerned, comparable to nasal continuous positive airway pressure.
Successful treatment of a young infant who developed high‐titer inhibitors against VWF‐cleaving protease (ADAMTS‐13): Important discrimination from Upshaw‐Schulman syndrome
Authors: Akira Ashida, Hyogo Nakamura, Atsushi Yoden, Hiroshi Tamai, Hiromichi Ishizashi, Hideo Yagi, Masanori Matsumoto, Yoshihiro Fujimura
Journal: American Journal of Hematology (2002)

Abstract We report herein the case of a 9‐month‐old female infant with acquired thrombotic thrombocytopenic purpura (TTP), which was initially suspected to be either Upshaw‐Schulman syndrome (USS or a congenital TTP) or hemolytic uremic syndrome (HUS) because of onset of clinical signs in infancy and accompanying diarrhea. She received combination therapy of plasma exchange, steroid pulse, and high‐dose intravenous immunoglobulin infusion that was initiated before the definitive diagnosis, which resulted in excellent clinical improvement. The retrograde analysis of plasma ADAMTS‐13 activity and its inhibitor showed a lack of this enzyme activity and the presence of a high‐titer IgG inhibitor (200–320 Bethesda units/mL) to this enzyme activity. From our experience, it was suggested that we should recognize the possibility of the patient with acquired TTP in infancy and the importance of plasma exchange therapy for management of its clinical symptoms. Am. J. Hematol. 71:318–322, 2002. © 2002 Wiley‐Liss, Inc.
Coeliac disease and schizophrenia: population based case control study with linkage of Danish national registers
Authors: William Eaton, Preben Bo Mortensen, Esben Agerbo, Majella Byrne, Ole Mors, Henrik Ewald
Journal: BMJ (2004)

invited chose not to undertake self management and may therefore not consider this a desirable option.To our knowledge this is the first UK trial that invited unselected patients to self manage warfarin and as such may give a real indication of expected uptake.For patients keen to undertake self management three quarters were able to complete training.These patients considered it a convenient and valuable method of controlling their own health and most were enthusiastic to continue after the trial.If self management by patients is to become established standardisation and dissemination of training are needed, accompanied by practical guidelines to encourage back up from clinicians.Contributors: EM managed the study, drafted the paper, and is a lead investigator.DF is principal investigator and critically revised the paper.DMcC and CF were research associates involved in field work, training, and assessing patients' data collection and management, and both reviewed the paper.HS pro-
CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes
Authors: W A Dik, W Brahim, C Braun, V Asnafi, N Dastugue, O A Bernard, J J M van Dongen, A W Langerak, E A Macintyre, E Delabesse
Journal: Leukemia (2005)
Antiphospholipid antibodies and adrenal hemorrhage
Authors: Robert D. McCroskey, Anthony Phillips, Frank Mott, Eliot C. Williams
Journal: American Journal of Hematology (1991)

We recently encountered two cases of massive bilateral adrenal hemorrhage in patients with antiphospholipid antibodies. A search of the records of this institution covering the past 15 years revealed two additional patients with massive adrenal hemorrhage associated with evidence of antiphospholipid antibodies. Three of these four patients were receiving anticoagulant drug therapy. The presence of the antiphospholipid antibodies may increase the risk of massive adrenal hemorrhage, particularly in patients who receive anticoagulant drugs.