Ebola Virus and Hemorrhagic Fever: Andromeda Strain or Localized Pathogen?
Authors: KARL M. JOHNSON
Journal: Annals of Internal Medicine (1979)

Editorial1 July 1979Ebola Virus and Hemorrhagic Fever: Andromeda Strain or Localized Pathogen?KARL M. JOHNSON, M.D.KARL M. JOHNSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-117 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe nearly simultaneous occurrence of major epidemics of acute hemorrhagic fever with high mortality in Sudan (1) and Zaire (2) during late 1976 serves as a poignant reminder that infectious "plagues" have not been, nor are they likely soon to be, eliminated from our world. The causative agent of these epidemics was found to be a virus new to science and was named Ebola after a small river near Yambuku, Zaire, a disease epicenter where the initial isolate was made (3-5).Ebola virus is a morphologic relative of Marburg virus, a peculiar rodshaped agent that somehow infected a group of...References1. Ebola haemorrhagic fever in Sudan, 1967: report of a WHO/International Study Team. Bull WHO. 1978;56:247-70. MedlineGoogle Scholar2. Ebola haemorrhagic fever in Zaire, 1976: report of an International Commission. Bull WHO. 1978;56:271-93. MedlineGoogle Scholar3. JOHNSONWEBBLANGEMURPHY KPJF. Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire. Lancet. 1977;1:569-71. CrossrefMedlineGoogle Scholar4. BOWENPLATTLLOYDBASKERVILLEHARRISVELLA EGGAWE. Viral haemorrhagic fever in southern Sudan and northern Zaire: preliminary studies on the aetiological agent. Lancet. 1977;1:571-3. CrossrefMedlineGoogle Scholar5. PATTYNJACOBVAN DER GROENPIOTCOURTEILLE SWGPG. Isolation of Marburg-like virus from a case of haemorrhagic fever in Zaire. Lancet. 1977;1:573-4. CrossrefMedlineGoogle Scholar6. MARTINI G. Marburg virus disease: clinical syndrome. In: MARTINI GA, SIEGERT R, eds. Marburg Virus Disease. New York: Springer-Verlag; 1971:1-9. CrossrefGoogle Scholar7. STILLEBÖHLE WE. Clinical course and prognosis of Marburg virus ("green-monkey") disease. See Reference 6, pp. 10-8. Google Scholar8. EGBRINGSLENCZKABALTZER RWG. Clinical manifestations and mechanism of the haemorrhagic diathesis in Marburg virus disease. See Reference 6, pp. 41-9. Google Scholar9. GEARCASSELGEAR JGA. Outbreak of Marburg virus disease in Johannesburg. Br Med J. 1975;4:489-93. CrossrefMedlineGoogle Scholar10. SLENCZKAWOLFFSIEGERT WGR. A critical study of monkey sera for the presence of antibody against the Marburg virus. Am J Epidemiol. 1971;93:496-505. CrossrefMedlineGoogle Scholar11. EMONDEVANSBOWENLLOYD RBEG. A case of Ebola virus infection. Br Med J. 1977;2:541-4. CrossrefMedlineGoogle Scholar12. BOWENBASKERVILLECANTELLMANNSIMPSONZUCKERMAN EAKGDA. The effect of interferon on experimental Ebola virus infection in rhesus monkeys. In: PATTYN SR, ed. Ebola Virus Haemorrhagic Fever. Amsterdam: Elsevier/North-Holland Inc.; 1978:245-52. Google Scholar13. . Classification of Etiologic Agents on the Basis of Hazard. 4th ed. Atlanta: Office of Biosafety, Center for Disease Control; 1974. Google Scholar14. . Recombinant DNA research: proposed revised guidelines. Fed Regist. 1978;43:33042-178. MedlineGoogle Scholar15. EICKHOFF T. Containing Andromeda. N Engl J Med. 1977;297:835-6. Editorial. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Special Pathogens Branch Virology Division Bureau of Laboratories Center for Disease Control Atlanta, Georgia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFièvre hémorragique à virus Ebola. Etude de 1 517 sérums du Cameroun 1 July 1979Volume 91, Issue 1Page: 117-119KeywordsEbola virusHemorrhagic feversMortalityPathogensRivers Issue Published: 1 July 1979 PDF DownloadLoading ...