tbuckley/cabot-search huggingface dataset:
A new way to evaluate the germinative compartment in human epidermis, using [3H]thymidine incorporation and immunoperoxidase staining of 67 K polypeptide
Authors: D. NESTE, M.J. STAQUET, J. VIAC, J.M. LACHAPELLE, J. THIVOLET
Journal: British Journal of Dermatology (1983)

We have used tritiated thymidine (3HT) labelling and immunoperoxidase staining of 67 K polypeptide in human epidermis to study normal skin before and after irritation induced by application of croton oil (20% and 50% in olive oil). By this double labelling method, it was possible to identify, on the same skin section, DNA-synthesizing nuclei and epidermal cells which contained 67 K polypeptide. Our results clearly indicate that the germinative compartment of normal epidermis is a mixed population comprising basal and adjacent suprabasal cells; as a rule, absence of expression of 67 K polypeptide, which characterizes all basal cells, could not be regarded as a good marker to distinguish the germinative from the differentiating compartments. In mild primary irritation, the ratio of 3HT-labelled undifferentiated cells to keratinizing ones was similar to that observed in normal epidermis. In severe irritation, this homeostatic process was altered, as 3HT-labelled cells were mainly 67 K negative.
Mystery of Insulin Binding Revealed
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial
Authors: Paul Ellis, Peter Barrett-Lee, Lindsay Johnson, David Cameron, Andrew Wardley, Susan O'Reilly, Mark Verrill, Ian Smith, John Yarnold, Robert Coleman, Helena Earl, Peter Canney, Chris Twelves, Christopher Poole, David Bloomfield, Penelope Hopwood, Stephen Johnston, Mitchell Dowsett, John MS Bartlett, Ian Ellis, Clare Peckitt, Emma Hall, Judith M Bliss
Journal: The Lancet (2009)
Clamoring for Quiet: New Ways to Mitigate Noise
Authors: John Manuel
Journal: Environmental Health Perspectives (2005)

New technologies are providing innovative ways to reduce sound levels in many areas. Aircraft engineers are finding ways to reduce the noise produced by jet engines, while road builders are using rubber-enhanced pavement to quiet highway noise. Indoor acoustics are benefiting from materials that transform sound waves to heat, and so-called active noise control reduces harmful sounds through production of a mirror-image sound field. And new lawn equipment makes weekends at home quieter for yard lovers and their neighbors.
Acute liver injury associated with the use of ebrotidine, a new H 2 -receptor antagonist
Authors: Raúl J Andrade, M.Isabel Lucena, Rafael Martin-Vivaldi, M.Carmen Fernandez, Flor Nogueras, Gloria Pelaez, Antonio Gomez-Outes, M Dolores Garcia-Escaño, Vicente Bellot, Antonio Hervás, Francisco Cárdenas, Francisco Bermudez, Manuel Romero, Javier Salmerón
Journal: Journal of Hepatology (1999)
The Role of Platelet-Derived Growth Factor Signaling in Healing Myocardial Infarcts
Authors: Pawel Zymek, Marcin Bujak, Khaled Chatila, Anna Cieslak, Geeta Thakker, Mark L. Entman, Nikolaos G. Frangogiannis
Journal: Journal of the American College of Cardiology (2006)
Abstract 2172: Anti-oncogenic role of peroxisome proliferator-activated receptor-α/β (PPARδ/α) involves inhibition of mitosis and regulation of Hras1-induced senescence
Authors: Bokai Zhu, Combiz Khozoie, Christina H. Ferry, Lauren M. Markell, Moses T. Bility, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez
Journal: Cancer Research (2012)

Abstract Ligand activation of PPARδ/α inhibits chemically-induced skin tumorigenesis and Pparα/α-null mice exhibit enhanced chemically-induced skin tumorigenesis compared to wild-type mice. The mechanism that mediates inhibition of skin carcinogenesis by PPARδ/α is still being unraveled and was examined in this study. Ligand activation of PPARδ/α caused a negative selection against cells expressing higher levels of HRAS by inducing a mitotic block. Mitosis-related genes that are predominantly regulated by E2F were induced to a higher level in HRAS-expressing Pparα/α-null keratinocytes as compared to HRAS-expressing wild-type keratinocytes. Ligand activated PPARδ/α repressed expression of these genes by direct binding with p130/p107, facilitating nuclear translocation, and increasing promoter recruitment of p130/p107. In addition, co-treatment with a PPARδ/α ligand and various mitosis inhibitors increases the efficacy of increasing G2/M arrest. PPARδ/α is also required for HRAS-induced senescence and suppression of malignant conversion of benign papillomas. HRAS-expressing Pparα/α-null keratinocytes evade senescence by utilizing the PI3K-AKT rather than the MEK-ERK pathway. PPARδ/α positively regulates MEK-ERK pathway by maintaining RASGRP1 levels and negatively regulating the PI3K-AKT pathway by repressing ILK and PDPK1 expression. Heightened AKT activity increases endoplasmic reticulum (ER) stress in Pparα/α-null keratinocytes, which in turn helps maintain higher AKT activity, leading to evasion of senescence. In addition, enhanced HRAS activity increases the synthesis of endogenous PPARδ/α ligands, thus providing a PPARδ/α-dependent cell-autonomous mechanism to suppress HRAS-induced carcinogenesis. (Supported by CA124533). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2172. doi:1538-7445.AM2012-2172
Abortion and Huntington's chorea.
Authors: J. M. Bolt
Journal: BMJ (1968)

While it is certainly more difficult to acquire the skill and technique of pelvic examination in the left lateral position, once acquired, it is not only as effective a means of pelvic examination but the pouch of Douglas is more easily assessed, and, as Marion Sims discovered, the anterior wall of the vagina is much better visualized.Howkins rightly draws attention to this in Operative Gynae- cology.'There can be no doubt whatsoever that this method of gynaecological examina- tion is much less embarrassing for the patient.With its special advantages, it would be a pity if it were discarded simply to mimic our transatlantic colleagues.-Iam, etc., Windsor.
Determination of Red Blood Cell Potassium
Authors: Hans G. Keitel
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The communication, "Red Blood Cell Potassium: Therapeutic Implications," by Singer et al, which appeared in the Jan 4, 1964, issue ofThe Journal(<b>187</b>:24), raised questions which surely should be answered, since they have distinct clinical pertinence. The question of a relationship between potassium content of red blood cells (RBC) and that of other body cells is a matter of great interest because of the easy availability of RBC and the knowledge that serious disturbances in cell potassium content may impair intracellular metabolism and lead eventually to necrosis. Unfortunately, the authors used methodology which does not facilitate the procurement of precise data. Specifically, the indirect method they used for determining the RBC potassium content suffers the major disadvantage of cumulative errors, namely, that of combined errors regarding the plasma potassium, whole blood potassium, and the hematocrit determinations. This method has been commented on by Peters and
Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking
Authors: Michel C Van den Oever, Natalia A Goriounova, Ka Wan Li, Roel C Van der Schors, Rob Binnekade, Anton N M Schoffelmeer, Huibert D Mansvelder, August B Smit, Sabine Spijker, Taco J De Vries
Journal: Nature Neuroscience (2008)
314 INTRATUMORAL TREATMENT WITH DENDRITIC CELLS ENGINEREED TO EXPRESS CD40L OR CD40L AND IL-2 INDUCES INHIBITION OF SUBCUTANEOUS HEPATOCELLULAR TUMOR GROWTH IN MICE
Authors: A. Vogt, W. Demmer, W.H. Caselmann, T. Sauerbruch, M.A. Gonzalez-Carmona
Journal: Journal of Hepatology (2009)
Atropine, sodium cromoglycate, and thymoxamine in PGF2 alpha-induced bronchoconstriction in extrinsic asthma.
Authors: K R Patel
Journal: BMJ (1975)

In six patients with extrinsic bronchial asthma the inhalation of prostaglandin (PG) F2 alpha in a small dosage produced significant bronchoconstriction, whereas PGE2 produced bronchodilatation. In these patients cholinergic blockade with atropine partially inhibited the PGF2 alpha-induced bronchoconstriction, but the alpha-receptor-blocking drug thymoxamine and sodium cromoglycate did not. These results suggest that the effect of PGF2 alpha is mediated through cholinergic receptors in the airways, and this effect is grossly exaggerated in asthma. The failure to inhibit PGF2 alpha-induced bronchoconstriction with sodium cromoglycate and the observation of an inhibitory effect of sodium cromoglycate in both allergic and exercise asthma suggest that locally formed PGF2 alpha may not be the main factor in the pathogenesis of bronchial asthma.
Management of Dyspnea
Authors: Francis W. Palfrey
Journal: New England Journal of Medicine (1952)

MEASURES seemingly too simple to be described in textbooks sometimes give the patient more comfort than those theoretically more important. Thus, when a retired professor of surgery with increasing dyspnea on effort recently took pains to express to the author his gratitude for the following thoughts, described casually at a medical luncheon some weeks before, it may be well to give these thoughts wider expression.Dyspnea, whether of cardiac origin or due to exertion by a normal person, was formerly described as resulting from the accumulation in the blood of carbon dioxide, formed by the combination of carbon and oxygen . . .
Nasogastric Tubes Permit Reflux and Aspiration: Is There Any Evidence?
Authors: Donald O. Castell
Journal: Annals of Internal Medicine (2000)

Letters4 April 2000Nasogastric Tubes Permit Reflux and Aspiration: Is There Any Evidence?Donald O. Castell, MDDonald O. Castell, MDGraduate Hospital; Philadelphia, PA 19146 (Castell)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was intrigued by Ferrer and colleagues' report (1) on the effect of nasogastric tube size on gastroesophageal reflux and microaspiration. In this excellent study comparing a small-bore (2.85-mm) with a large-bore (6.0-mm) nasogastric tube, the authors showed absolutely no difference in detection of a radiolabeled refluxate in either the pharynx or trachea. They correctly indicate that there is no rationale for the current belief that reducing the bore size of a nasogastric tube may improve prophylaxis against both reflux and pneumonia. They also support the guidelines of the Centers for Disease Control and Prevention, which do ...References1. Ferrer M, Bauer TT, Torres A, Hernández C, Piera C. Effect of nasogastric tube size on gastroesophageal reflux and microaspiration in intubated patients. Ann Intern Med. 1999;130:991-4. LinkGoogle Scholar2. Kuo B, Castell DO. The effect of nasogastric intubation on gastroesophageal reflux: a comparison of different tube sizes. Am J Gastroenterol. 1995;90:1804-7. MedlineGoogle Scholar3. Fisher RS, Malmud LS, Roberts GS, et al . Gastroesophageal (GE) scintiscanning to detect and quantitate GE reflux. Gastroenterology. 1976;70:301-8. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Graduate Hospital; Philadelphia, PA 19146 (Castell) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Nasogastric Tube Size on Gastroesophageal Reflux and Microaspiration in Intubated Patients Miquel Ferrer , Torsten Thomas Bauer , Antoni Torres , Carmen Hernández , and Carlos Piera Metrics Cited ByInfluence of nasogastric tubes on gastroesophageal reflux in preterm infants: A multiple intraluminal impedance study 4 April 2000Volume 132, Issue 7Page: 594-595KeywordsEatingEsophagusGastroesophageal reflux diseasePharynxPneumoniaProphylaxisResearch laboratoriesTrachea Issue Published: 4 April 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
OSTEOTOMY FOR FLEXION DEFORMITY AT THE HIP DUE TO ANTERIOR POLIOMYELITIS
Authors: EDWIN W. RYERSON
Journal: JAMA (1933)

Contracture of the hip in flexion and abduction is a common deformity in cases of infantile paralysis. The resulting disability is so severe and so difficult to relieve that open operation is always necessary in cases of long duration. It is with regard to the operative technic that this paper has been written. The contracture is caused primarily by a shortening of the tensor fasciae femoris, but in the course of time the gluteus medius, the iliopsoas and the rectus femoris become shortened, as do even the iliofemoral ligament and the capsule. As in most poliomyelitic deformities, prevention is less difficult than cure. While the child lies in bed during the early stages of the attack of infantile paralysis, the easy and comfortable position is with the thighs widely abducted and the knees flexed. This is the worst possible position, because it allows the tensor fasciae latae and the thigh
Mohan Lal Poddar
Authors: Prem Misra
Journal: BMJ (2005)

​GeneralGeneral practitioner Barrhead, Glasgow, 1968-96 (b 1929; q Darbhanga, Bihar, India, 1953; DTM&H, DCH, MRCGP), died from a heart attack on 29 May 2005.




Figure 1




After senior house officer posts in Patna, and general practice in Bihar, he came to the United Kingdom in 1965 and worked as an SHO and a registrar in Boston, Edinburgh, Leicester, and Glasgow. He started his singlehanded practice in 1968. He celebrated his diamond wedding anniversary in April 2005. He leaves a wife, Kailash Devi; three sons; and seven grandchildren.
Are Urban Mental Health Centers Worth It? Part II
Authors: J. M. STUBBLEBINE, J. BARRY DECKER
Journal: American Journal of Psychiatry (1971)

The authors examine the value of community mental health centers, using the San Francisco system as a model. This system shows a reduction in distant state and local hospital use and therefore a reduction in expenditures. The changing pattern of care requires coordinated but multiple treatment options and crisis intervention. When an urban program is organized in this way, more efficient use can be made of state and county tax dollars, and expenditures can often be reduced.
Cytisine versus Nicotine for Smoking Cessation
Authors: Witold Zatoński, Mateusz Zatoński
Journal: New England Journal of Medicine (2015)

To the Editor: Walker et al. (Dec. 18 issue)1 describe the use of cytisine, as compared with nicotine, for smoking cessation. Although cytisine is perceived as a novelty in the West, it has been used in daily medical practice in Poland for more than 50 years.2 In 1976, the first English-language study on the use of cytisine in Poland was published, based on the observations of 1968 patients.3 Cytisine is currently undergoing a renaissance in Poland. Two Polish studies — a cohort study conducted in 2003 through 20054 and a randomized, controlled trial conducted in 2006 through 20105 — showed . . .
Hyperglucagonemia and hyperammonemia: Which is the chicken and which the egg?
Authors: Harold O. Conn, L. Siw Eriksson
Journal: Hepatology (1986)

Elevated plasma ammonia level in hepatic cirrhosis has been attributed to a lack ofconversion of enteric ammonia into urea or to its entry into systemic circulation via portasystemic shunting, or to both. It is exaggerated by excessive protein intake. Because hyperglucagonemia is well documented in cirrhosis and a protein meal is an effective glucagon secretogogue, plasma glucose, insulin, glucagon, and ammonia levels were determined in 50 cirrhotic patients after an overnight fast. Effects of a protein meal were also assessed in 20 of these patients. Plasma glucose was normal and remained unaltered after a protein meal. Insulin, glucagon and ammonia levels were elevated, but only in patients with advanced liver dysfunction. Ammonia levels correlated significantly with glucagon (r = 0.61, p < 0.001), but not with insulin or glucose levels. Insulin and glucagon levels rose after a protein meal in all patients and controls, whereas a significant rise in the ammonia level occurred only in decompensated cirrhotics. Elevation of the ammonia level was significantly correlated with fasting glucagon (r = 0.54, p < 0.05), as well as with glucagon response (r = 0.65, p < 0.01), but not with basal insulin or insulin response. Furthermore, the rise in ammonia level occurred too early to be accounted for by enteric generation. Finally, direct effects of glucagon administration on plasma glucose and serum ammonia were examined in 15 cirrhotic patients. Glucose response was significantly blunted in cirrhotic patients as compared with normal subjects, whereas serum ammonia rose promptly but only in cirrhotics with maximum rise being noted in cirrhotic patients with advanced liver dysfunction. This study, therefore, suggests that hyperglucagonemia may contribute significantly to hyperammonemia in hepatic cirrhosis.
Does Seasonal Influenza Vaccination Increase the Risk of Illness with the 2009 A/H1N1 Pandemic Virus?
Authors: Cécile Viboud, Lone Simonsen
Journal: PLoS Medicine (2010)

This Perspective discusses the following study published in PLoS Medicine: Skowronski DM, De Serres G, Crocroft N, Janjua NZ, Boulianne N, et al. (2010) Association between the 2008-09 Seasonal Influenza Vaccine and Pandemic H1N1 Illness during Spring-Summer 2009 : Four Observational Studies from Canada. PLoS Med 7(4): e1000258. doi:10.1371/journal.pmed.1000258. In three case-control studies and a household transmission cohort, Danuta Skowronski and colleagues find an association between prior seasonal flu vaccination and increased risk of 2009 pandemic H1N1 flu.
Episodic evolution and rapid divergence of members of the rat multigene family encoding the salivary prohormone-like protein SMR1
Authors: Y. Courty, M. Singer, I. Rosinski-Chupin, F. Rougeon
Journal: Molecular Biology and Evolution (1996)

In rodents, the variable coding sequence (VCS) multigene family displays extensive evolutionary divergence in the protein-coding region. While certain VCS genes coding for proline-rich proteins (hPR-PB, mMSG1, rPR-VB1) are conserved in primates and rodents, others seem to be specific to certain genera. This appears to be the case for the Rattus genes forming the A-subclass. This subclass is composed of three genes in R. norvegicus and probably five genes in R. rattus. The first described VCSA gene (Rn. VCSA1) was found to encode a prohormone-like protein named SMR1 (-VA1), expressed mainly in the submandibular glands (SMG) of male rats. To further understand the evolution of this variable multigene family, we have cloned the two additional genes (Rn. VCSA2 and Rn. VCSA3) forming the R. norvegicus A-subclass and three VCSA genes (Rr. VCSA1a, b and Rr. VCSA2) of R. rattus. The putative SMR1 proteins encoded by all these genes display the same prohormone-like structure as Rn. SMR1-VA1. However, we observe a polymorphism in some internal cleavage sites which suggests that multiple processing of the SMR1 proteins could result in the liberation of peptides differing in structure and length. The phylogenetic analysis of the sequences reveals that the duplication events giving rise to the VCSA1, -A2, and -A3 progenitors were anterior to the R. norvegicus and R. rattus split, and that a VCSA1 duplication event likely occurred specifically in R. rattus. A striking observation is that the coding sequences of the VCSA genes have rapidly diverged from their ancestors. Along all branches of the phylogeny, the nonsynonymous divergence rate is identical or superior to the synonymous divergence rate. We suggest that frequent changes in functional requirements are mainly responsible for the episodic evolution and the rapid divergence of the VCSA genes.
457 TYPE II GROUND GLASS HEPATOCYTES CO-EXPRESS HBSAG AND HBX PROTEINS AND REPRESENT PRENEOPLASTIC LESIONS
Authors: H.C. Wu, W.C. Hsieh, C.F. Teng, L.H.C. Wang, H.W. Tsai, Q. Yuan, J. Zhang, I.J. Su
Journal: Journal of Hepatology (2012)
Veterinary and Comparative Dermatology
Authors: P. C. Anderson
Journal: JAMA (1964)

"Between animal and human medicine there is no dividing line—nor should there be," said Rudolph Virchow, stating the common interests of the veterinarian and the student of human disease. For the physician this revision of an older text,<i>Veterinary Dermatology</i>, by Král and Novak, originally published in 1953, is disappointing. Despite many improvements it leaves much to be desired. Many sections of the book are modern, but it is disappointing to find other sections, such as that on pemphigus, showing all the confusion of the dermatology of 80 years ago. Unsupported assumptions about etiology and inconstant attention to new concepts from human dermatology are disturbing. In too few places are skin diseases of animals and man compared, as promised in the title of the book. To the physician well trained in dermatology, much of the book is stimulating. The anatomic and physiological approach to disease is well developed in the
Functional and genetic aberrations of in vitro-cultured marrow-derived mesenchymal stromal cells of patients with classical Philadelphia-negative myeloproliferative neoplasms
Authors: M A Avanzini, M E Bernardo, F Novara, M Mantelli, V Poletto, L Villani, E Lenta, D M Ingo, V Achille, E Bonetti, M Massa, R Campanelli, G Fois, P Catarsi, R P Gale, A Moretta, A Aronica, R Maccario, G Acquafredda, D Lisini, M Zecca, O Zuffardi, F Locatelli, G Barosi, V Rosti
Journal: Leukemia (2014)