Digitalis Serum Levels: Clinical Use
Authors: JAMES E. DOHERTY
Journal: Annals of Internal Medicine (1971)

Editorials1 May 1971Digitalis Serum Levels: Clinical UseJAMES E. DOHERTY, M.D.JAMES E. DOHERTY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-787 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIndications that digitalis serum levels might be of value in clinical practice came in studies with radioactive digitalis compounds that appeared to relate the serum level of the drug to the myocardial level. The myocardial levels of radiocarbon digitoxin first reported by Okita and associates (1-3) were not specifically related to the serum levels, probably because of the small number of patients investigated. Gonzales and Layne (4) studied tritiated digoxin serum and tissue levels in dogs (1960) and suggested that human studies might be of value. Doherty, Perkins, and Mitchell (5) reported human studies with tritiated digoxin; these indicated that...References1. OKITAKELSEYTALSO GFP: Studies on the renal excretion of radioactive digitoxin in human subjects with cardiac failure. Circulation 7:161, 1953 CrossrefMedlineGoogle Scholar2. OKITAKELSEYWALASZEK GFE: Biosynthesis and isolation of carbon-14 labeled digitoxin. J Pharmacol Exp Ther 110:244, 1954 MedlineGoogle Scholar3. OKITA G: Studies with radioactive digitalis. J Amer Geriat Soc 5:163, 1957 CrossrefMedlineGoogle Scholar4. GONZALESLAYNE LE: Studies on tritium-labeled digoxin: tissue, blood and urine determinations. J Clin Invest 39: 1578-1583, 1960 CrossrefMedlineGoogle Scholar5. DOHERTYPERKINSMITCHELL JWG: Serum half-life of tritiated digoxin in congestive heart failure (abstract). Clin Res 8:43, 1960 Google Scholar6. DOHERTYPERKINSMITCHELL JWG: Tritiated digoxin studies in human subjects. Arch Intern Med (Chicago) 108: 531-539, 1961 CrossrefMedlineGoogle Scholar7. 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In press Google Scholar14. DOHERTYPERKINSFLANIGAN JWW: The distribution and concentration of tritiated digoxin in human tissues. Ann Intern Med 66:116-124, 1967 LinkGoogle Scholar15. BUTLERCHEN VJ: Digoxin-specific antibodies. Proc Nat Acad Sci USA 57:71-78, 1967 CrossrefMedlineGoogle Scholar16. OLIVERPARKERBRASFIELD GBD: The measurement of digitoxin in human serum by radioimmunoassay. J Clin Invest 47:1035-1040, 1968 CrossrefMedlineGoogle Scholar17. SMITHBUTLERHABER TVE: Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. New Eng J Med 281:1212, 1969 CrossrefMedlineGoogle Scholar18. SMITHHABER TE: Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration. J Clin Invest 49:2377, 1970 CrossrefMedlineGoogle Scholar19. BELLERHOODABELMANN GWW: Digitalis intoxication: a prospective clinical study with serum level correlations. Circulation 52 (suppl III): 110, 1970 Google Scholar20. SMITHHABER TE: Radioimmunoassay of serum digoxin and digitoxin in toxicity and malabsorption states. Circulation (suppl III) 39 and 40:188, 1969 Google Scholar21. DOHERTYPERKINS JW: Digoxin metabolism in hypoand hyperthyroidism. Studies with tritiated digoxin. Ann Intern Med 64:489-507, 1966 LinkGoogle Scholar22. LUCHIGRUBER RJ: Unusually large digitalis requirements. A study of altered digoxin metabolism. Amer J Med 45:322-328, 1968 CrossrefMedlineGoogle Scholar23. DOHERTYPERKINSWILSON JWM: Studies with tritiated digoxin in renal failure. Amer J Med 37:536-544, 1964 CrossrefMedlineGoogle Scholar24. MARCUSPETERSONSALEL FAA: The metabolism of tritiated digoxin in renal insufficiency in dogs and man. J Pharmacol Exp Ther 152:372-382, 1966 MedlineGoogle Scholar25. DOHERTYFLANIGANMURPHY JWM: Tritiated Digoxin XIV: Enterohepatic circulation, absorption, and excretion studies in human volunteers. Circulation 42:867, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES E. DOHERTY, M.D.Affiliations: University of Arkansas School of Medicine Little Rock, Ark. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCorrelative studies of serum digitalis levels and the arrhythmias of digitalis intoxicationCurrent Considerations in Digoxin UsageThe binding of drugs to plasma proteins and the interpretation of measurements of plasma concentrations of drugs in patients with poor renal functionApparent Resistance to Digoxin and HyperthyroidismCardiovascular Complications of Urologic SurgerySerum Digitalis Level—Practical ValueClinical Pharmacy CASE StudiesTherapeutic Serum Digoxin Concentration: Relation to Age, Weight, Sex, and Serum Creatinine Levels‡‡New developments and therapeutic applications of cardiac stimulating agentsRole of Pharmacokinetics in Drug Dosage Adjustment. I. Pharmacologic Effect Kinetics and Apparent Volume of Distribution of DigoxinPharmacokinetic Aspects of Controlled Drug Delivery SystemsAntibodies to Small Molecules: Biological and Clinical ApplicationsSerum Digoxin Determination by RadioimmunoassayAssays of digitalis in the bloodTritiated digoxinClinical Pharmacology of DigoxinDigitalis Assay by Salivary ElectrolytesFALLIBILITY OF PLASMA-DIGOXIN IN DIFFERENTIATING TOXIC FROM NON-TOXIC PATIENTS 1 May 1971Volume 74, Issue 5Page: 787-789KeywordsDrugs ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...