tbuckley/cabot-search huggingface dataset:
TOPICAL TREATMENT OF PSORIASIS WITH TRIETHYLENETHIOPHOSPHORAMIDE (THIO-TEPA)
Authors: G. HEYDENREICH
Journal: British Journal of Dermatology (1971)

SUMMARY.— Fourteen patients with previously therapy‐resistant, severe chronic, infiltrated psoriasis were treated with the alkylating compound, thio‐tepa 0.4% in soft ointment P.N.* with occlusive dressing for 8 h each day. Complete clearing of the psoriatic lesion occurred in 11 of the patients after an average of 19 days treatment. In 2 patients it was necessary to discontinue the treatment owing to leukopenia after 14 and 20 days respectively. Two patients developed moderate local irritation, which did not, however, necessitate the cessation of treatment. It is concluded that thio‐tepa 0.4% in soft ointment P.N. is an effective agent for the treatment of otherwise resistant psoriatic plaques.
Promotion of electronic cigarettes: tobacco marketing reinvented?
Authors: M. d. Andrade, G. Hastings, K. Angus
Journal: BMJ (2013)

Electronic cigarettes are not subject to the same marketing controls as tobacco products. <b>Marisa de Andrade</b>, <b>Gerard Hastings</b>, and <b>Kathryn Angus</b> argue that their advertising is likely to appeal to young people and undermine tobacco control policy
Applying the implicit-explicit distinction to development in children
Authors: Ted Ruffman
Journal: Behavioral and Brain Sciences (1999)

This commentary focuses on how Dienes &amp; Perner's (D&amp;P's) claims relate to aspects of development. First, I discuss recent research that supports D&amp;P's claim that anticipatory looking in a false belief task is guided by implicit knowledge. Second, I argue that implicit knowledge may be based on exposure to regularities in the world as D&amp;P argue, but equally, it may sometimes be based on theories that conflict with real world regularities. Third, I discuss Munakata et al.'s notion of graded representations as an alternative to the implicit-explicit distinction in explaining dissociations in infancy.
Recollections of Charlie: Dr. Charles Alderson Janeway, Jr. (1943-2003)
Authors: Derek B. Sant'Angelo
Journal: The Journal of Experimental Medicine (2003)

“…one should always attempt to construct an internal image of the universe of knowledge, and then ask if a given publication can, in any significant way, modify that image” - Charles A. Janeway, Jr. (Presidential Address, AAI, 1998)



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Dr. Charles Alderson Janeway, Jr. (
Combined Endoscopic Transgastric and Transpapillary Drainage of an Infected Biloma
Authors: T. Baron
Journal: Endoscopy (2006)

A 61-year-old man underwent partial hepatectomy for metastases in the left lateral lobe. One month later, he developed intermittent fever. Abdominal computed tomography (CT) revealed a fluid collection 4.5 × 6.0 cm in size compressing the gastric wall (Figure [1]).
Multivessel Coronary Revascularization in Patients With and Without Diabetes Mellitus
Authors: Joost Daemen, Karl Heinz Kuck, Carlos Macaya, Victor LeGrand, Maarten Vrolix, Didier Carrie, Imad Sheiban, Maarten Jan Suttorp, Pascal Vranckx, Tessa Rademaker, Dick Goedhart, Monique Schuijer, Kristel Wittebols, Nathalie Macours, Hans Peter Stoll, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2008)
Inadequate post-publication review of medical research
Authors: D. L. Schriger, D. G. Altman
Journal: BMJ (2010)

A sign of an unhealthy research environment in clinical medicine

Imagine a vibrant field of scientific inquiry. Researchers focus on solving the most urgent uncertainties of the discipline and publish papers that, guided by reporting guidelines1 and further improved by pre-publication peer review, provide comprehensive accounts of their methods, findings, and limitations. The research community, keen to advance the field, engages in an active dialogue regarding the validity and implications of each new paper. Post-publication critique, as the final arbiter of the meaning of each new communication, is no less important than the earlier phases and is a sign of a healthy scientific community, a community actively working to move the field forward.2 3 4

In the linked study (doi:10.1136/bmj.c3926),5 Gotzsche and colleagues’ finding that authors of BMJ articles are reluctant to respond to criticisms submitted as rapid responses reinforces the finding of the few previous studies,4 6 7 which found consistent evidence that all aspects of post-publication review are wanting in medical research. Most research articles in medical journals receive no …
Patient Complaints Against Physicians in the Richmond Area During 1973
Authors: Charles L. Cooke
Journal: JAMA (1976)

THIRTY-FIVE formal complaints were lodged in writing against members of the Richmond Academy of Medicine during 1973. Each such complaint must be reviewed as a potential malpractice suit, and anything that can be done to prevent the soaring cost of malpractice appears to be warranted.<sup>1-3</sup>This communication identifies some problems in the practice of medicine and makes some suggestions to eliminate them. <h3>Reviewing Complaints</h3> The Mediations Committee of the Richmond Academy of Medicine is a standing committee to deal with complaints of patients against their physicians. The existence of this committee has not been publicized on a regular basis, and complaints have not been solicited but are dealt with as they arise. The only requirement for a complaint to be investigated is that it must be submitted in writing. There is no requirement that the patient himself must submit the complaint. On receipt of the written complaint, a member
Tropical deciduous forest: Death of a biome
Authors: Manuel Lerdau, Julie Whitbeck, N.Michele Holbrook
Journal: Trends in Ecology & Evolution (1991)

Erythrina gall wasp, Quadrastichus erythrinae (Hymenoptera: Eulophidae) began a global range expansion around 2005, and is considered a significant adventive pest in Asia, Pacific islands, South- and Central America, and North America, including Hawaii. The Hawaii endemic wiliwili tree, Erythrina sandwicensis (Fabaceae) was severely impacted and threatened with extinction, leading to the release of a classical biological control agent, Eurytoma erythrinae (Hymenoptera: Eurytomidae) from southern and East Africa, in 2008. Establishment was confirmed by retrievals of wasps within 1–4 months at all release locations. throughout Hawaii, and reduced impacts to trees within two years. By 2018, the majority of trees sampled incurred less than 33% gall damage to their foliage. E. erythrinae reduced Q. erythrinae damage by >85% in some locations throughout Hawaii and may have contributed substantially to preventing the extinction of this endemic tree.
A New Exanthem?
Authors: A. Letchner
Journal: BMJ (1960)

<h3>Abstract</h3> Here, we describe an information-theory-based method and associated software for computationally identifying sister spores derived from the same meiotic tetrad. The method exploits specific DNA sequence features of tetrads that result from meiotic centromere and allele segregation patterns. Because the method uses only the genomic sequence, it alleviates the need for tetrad-specific barcodes or other genetic modifications to the strains. Using this method, strains derived from randomly arrayed spores can be efficiently grouped back into tetrads.
A Severe Complication of the New Self-Expanding Spiral Nitinol Biliary Stent
Authors: P. Pescatore, H.-J. Meier-Willersen, B. C. Manegold
Journal: Endoscopy (1997)

The new spiral nitinol biliary stent offers some very promising features, including its long patency and retrievability. We report here the case of a patient in whom this type of stent was inserted for palliative treatment of a periampullary tumour. The stent migrated distally, and could not be withdrawn. The further course was complicated by duodenal obstruction, repeated bouts of cholangitis, and fatal hemorrhage after surgical removal of the endoprosthesis. The design of this new stent should be improved.
Description of a new technique using biopsy forceps to stabilize pedunculated polyps for confocal laser endomicroscopy (with video)
Authors: H. Neumann, M. Raithel, M. Neurath
Journal: Endoscopy (2010)

The recently introduced technique of confocal laser endomicroscopy (CLE) enables in-vivo microscopic imaging of the mucosal layer of the gut at a subcellular resolution [1] [2]. Several studies have shown that CLE has the potential to accurately discriminate between adenomatous and nonadenomatous colorectal polyps, and to enable the evaluation of the degree of dysplasia during ongoing endoscopy [3] [4]. Nevertheless, in practice it is often difficult to receive confocal images of pedunculated polyps that are in focus because the polyps often “flap” away from the endoscope, which prevents stable contact between the confocal lens and the polyp tissue. We were confronted with this problem in a patient undergoing surveillance colonoscopy. A large, 15-mm, pedunculated polyp with Kudo pit pattern 3S was visualized in the proximal sigmoid. Despite the size of the polyp, it was not possible to receive confocal images in focus because the polyp was repeatedly pushed away by the endoscope (Pentax EC-3870 CIFK, Tokyo, Japan). By grasping the head of the polyp with a standard biopsy forceps we could pull the polyp toward the confocal lens ([Video 1]; [Fig. 1 a – c]) and receive high-quality confocal images on CLE of the polyp ([Video 1]; [Fig. 1 d]).
Varices of the Entire Colon - an Unusual Cause of Recurrent Intestinal Bleeding
Authors: J. Weingart, W. Höchter, R. Ottenjann
Journal: Endoscopy (1982)

A case of recurrent intestinal bleeding caused by colonic varices is presented. Markedly dilated tortuous varices of the entire colon were found at colonoscopy. Esophagogastroduodenoscopy and the radiographic examination of the small bowel were normal. Pathological portal vein changes were excluded by mesenteric arteriography.
Reviews, Notes, and Listings: The Dictionary of Modern Medicine
Authors: Edward J. Huth
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 February 1993Reviews, Notes, and Listings: The Dictionary of Modern MedicineEdward J. Huth, MD, Editor EmeritusEdward J. Huth, MD, Editor EmeritusUniversity of Pennsylvania School of Medicine, Philadelphia, PA 19104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00044 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Dictionary of Modern MedicineJ. C. Segen. 800 pages. Park Ridge, New Jersey: Parthenon Publishing; 1992. $75.00.What is this “dictionary” and what is it not?First, it is a monument to Dr. Segen's industry and capacity for wide reading. Simply writing the text for 800 pages is an enormous task; mastering all of the detail and getting it down accurately merits praise. Many entries include citations of the journal literature and other sources that were the basis for this book's short articles, a feature seen in the Oxford English Dictionary but not in conventional medical dictionaries. Segen's entries include many terms ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania School of Medicine, Philadelphia, PA 19104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 237-238KeywordsChild psychiatryCreativityPathologistsPerceptionSurgeons Issue Published: 1 February 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Gene doping: Olympic genes for Olympic dreams
Authors: Lucy Battery, Andrew Solomon, David Gould
Journal: Journal of the Royal Society of Medicine (2011)

As we approach the London 2012 Olympics, sport finds itself facing a highly specific threat to its ethos of fair play. Defined by the World Anti-Doping Agency (WADA) as ‘the non-therapeutic use of genes, genetic elements and/or cells that have the capacity to enhance athletic performance’,1 gene doping presents a range of challenges to those involved in sport and exercise medicine and an urgent need for an understanding of its potential impact to healthcare.2,3
Prolonged Stability of Progressive Multifocal Leukoencephalopathy in a Patient With Chronic Lymphocytic Leukemia
Authors: Meng Zhang, Fumin Li, Michael Rasper, Ali G. Saad, Santosh Kesari
Journal: Journal of Clinical Oncology (2010)

A 72-year-old right-handed man with a medical history of chronic lymphocytic leukemia (CLL) noted progressive difficulties with handwriting.He was diagnosed 3 years prior and received chlorambucil, fludarabine, vincristine, cyclophosphamide, and rituximab.His treatments were held due to low white cell counts.He noted progressive clumsiness and weakness in the right hand over 3 months.A magnetic resonance imaging (MRI) of the brain showed increased T2-signal and enhancement in the left postcentral gyrus, right frontal white matter, and medial frontal lobe (Fig 1).The differential diagnosis included lymphoma, primary brain tumor, or progressive multifocal leukoencephalopathy (PML).He had normal WBC counts (4,130 cells/L) with normal CD4 and CD4/CD8 ratio at this time.Lumbar puncture for CSF evaluation was negative for malignant cells, inflammation, or infection.A brain biopsy was done and intraoperative smear preparation showed occasional oligodendroglial cells with viral cytopathic change (ie, nuclear enlargement A B C D Fig 1.
Shutting Down Hepatitis C . . .
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhanced HIV Testing, Treatment, and Support for HIV-Infected Substance Users
Authors: Nora D. Volkow
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Neurological Manifestations of Endogenous Hypoglycaemia
Authors: D. Moorhouse
Journal: BMJ (1956)

Hypoglycaemia has been recognized as a clinical entity for only about fifty years, although some of the mechanisms by which it may be produced must have been operating throughout the ages. After the introduc tion of insulin for the treatment of diabetes in 1922 insulin  reactions  were observed for the first time, and Seale Harris then realized that he had seen patients with similar symptoms who were not being given insulin ; thus in 1924 he introduced the concept of  spon taneous  hypoglycaemia (Harris, 1924), and since then papers too numerous to quote have been devoted to the subject. I have used the term  endogenous  rather than spontaneous because it is more accurate, since there must always be a reason for the development of hypo glycaemia even if it cannot be fully understood, and endogenous hypoglycaemia may be defined as the produc tion of an abnormally low blood-sugar level by any means other than the exogenous administration of insulin, usually giving rise to symptoms or, less often, to physical signs. My observations have been limited to those patients in whom hypoglycaemia appeared to be the primary factor in the production of symptoms, thereby excluding hypoglycaemia which is part of a complex biochemical syndrome, as in gross liver disease or endocrine disorders and in other uncommon conditions. There remain for consideration three main types of endogenous hypo glycaemia?namely, organic hyperinsulinism resulting from the presence of functioning pancreatic islet-cell tumours, hypoglycaemia arising as a sequel to various gastric operations, and psychosomatic hypoglycaemia.
Psychological therapy for anxiety in bipolar spectrum disorders: A systematic review
Authors: Hannah J. Stratford, Myra J. Cooper, Martina Di Simplicio, Simon E. Blackwell, Emily A. Holmes
Journal: Clinical Psychology Review (2014)

Comorbid anxiety is common in bipolar spectrum disorders [BPSD], and is associated with poor outcomes. Its clinical relevance is highlighted by the "anxious distress specifier" in the revised criteria for Bipolar Disorders in the Diagnostic and Statistical Manual 5th Edition [DSM-5]. This article reviews evidence for the effectiveness of psychological therapy for anxiety in adults with BPSD (bipolar I, II, not otherwise specified, cyclothymia, and rapid cycling disorders). A systematic search yielded 22 treatment studies that included an anxiety-related outcome measure. Cognitive behavioural therapy [CBT] for BPSD incorporating an anxiety component reduces anxiety symptoms in cyclothymia, "refractory" and rapid cycling BPSD, whereas standard bipolar treatments have only a modest effect on anxiety. Preliminary evidence is promising for CBT for post-traumatic stress disorder and generalised anxiety disorder in BPSD. Psychoeducation alone does not appear to reduce anxiety, and data for mindfulness-based cognitive therapy [MBCT] appear equivocal. CBT during euthymic phases has the greatest weight of evidence. Where reported, psychological therapy appears acceptable and safe, but more systematic collection and reporting of safety and acceptability information is needed. Development of psychological models and treatment protocols for anxiety in BPSD may help improve outcomes.
INTRAVENOUS CORTICOSTEROID USE IS ASSOCIATED WITH REDUCED EARLY RECURRENCE OF ATRIAL FIBRILLATION FOLLOWING RADIOFREQUENCY CATHETER ABLATION
Authors: Guru M. Krishnan, Nitesh A. Sood, Craig I. Coleman, Jeffrey Kluger, Moise Anglade, Christopher A. Clyne
Journal: Journal of the American College of Cardiology (2010)
Validation of a Doppler echocardiographic method for calculating severity of discrete stenotic obstructions in a canine preparation with a pulmonary arterial band.
Authors: L M Valdes-Cruz, S Horowitz, D J Sahn, D Larson, C Oliveira Lima, E Mesel
Journal: Circulation (1984)

The purpose of this study was to develop an open-chest animal preparation to validate the accuracy of a two-dimensional Doppler echocardiographic method for estimating pressure drops across discrete stenotic obstructions. Six mongrel dogs underwent median sternotomy and catheters were placed in the right ventricle, distal main pulmonary artery, and aorta of each. A 1/8 inch umbilical tape was sewn to the posterior rim of the pulmonary artery just above the anulus and was progressively tightened to vary the degree of stenosis. Ultrasound and Doppler studies were performed with a 2.5 MHz phased-array unit with capabilities for pulsed or continuous-mode Doppler and real-time imaging. Peak systolic main pulmonary arterial flow velocities were recorded by Doppler echocardiography within the jet distal to the band from an oblique parasternal short-axis echocardiographic view and corrected for angle of incidence between the direction of Doppler sampling and the presumed direction of flow. Doppler velocities were converted to gradients with a simplification of the Bernoulli equation (gradient = 4 X maximal Doppler flow velocity2 ). Maximal Doppler-determined systolic pulmonary arterial velocities showed a good linear correlation with the 63 measured pressure drops (r = .95, SEE +/- 36.3 cm/sec). An excellent correlation was also found between Doppler-calculated and actual pressure gradients (r = .96, SEE +/- 7.26 mm Hg). Our results suggest that this Doppler method for measuring gradients across discrete stenotic obstructions may be quite accurate in clinical applications.