tbuckley/cabot-search huggingface dataset:
Consent Form With Signature
Authors: Richard Jones
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recurrence of Diabetes After Diarrhea-Associated Hemolytic Uremic Syndrome
Authors: Kristina Casteels, Rita Van Damme-Lombaerts
Journal: Diabetes Care (2006)

We read with interest the article by Suri et al. (1). In this article, we find a systematic review and meta-analysis of articles assessing diabetes during diarrhea-associated hemolytic uremic syndrome (D+HUS). The 21 included studies describe 49 children who developed diabetes during acute D+HUS. Long-term outcome was reported for 44 of 49 children: 13 of 34 survivors were left with persistent diabetes requiring insulin; 11 had persistent diabetes from the outset, while 2 …
Teenager seeks to overturn GMC judgment
Authors: Clare Dyer
Journal: BMJ (2004)

A teenager with chronic fatigue syndrome this week challenged the decision of the General Medical Council to clear a paediatrician who interfered in her case without her parents' consent.

At the High Court in London, lawyers for Miss A, aged 18, whose identity is protected by court order, accused the GMC of reaching a legally flawed decision in acquitting Christopher Cheetham of serious professional misconduct.

Her counsel, David Wolfe, told Mr Justice Charles that Dr Cheetham, then a consultant paediatrician at Wycombe General Hospital, High Wycombe, Buckinghamshire, had continued to intervene after her parents opted for treatment by a different paediatrician.

If the …
Glomerular permselectivity in proteinuric patients after kidney transplantation.
Authors: R Oberbauer, M Haas, H Regele, U Barnas, A Schmidt, G Mayer
Journal: Journal of Clinical Investigation (1995)

To characterize the defect in glomerular permselectivity responsible for proteinuria after renal transplantation, we studied 10 patients with moderate proteinuria (median 0.37 g/d, range 0.20-0.79), 16 patients with the nephrotic syndrome (6.73 g/d, 3.9-14.6), 8 living related donor transplant recipients without any history of rejection (median proteinuria 0.26 g/d, 0.06-0.58), and 12 healthy volunteers. The fractional clearance of neutral dextrans > 54 A was significantly higher in nephrotic patients, demonstrating a defect in glomerular size selectivity. Using a log-normal model of glomerular pore size distribution, r*(5%) and r*(1%), indices for the presence of large pores, were increased in the nephrotic patients. The fractional clearance of negatively charged dextran sulfate was significantly higher in all patient groups, indicating a loss of glomerular charge selectivity. Biopsy findings showed more prominent glomerular lesions in the nephrotic group compared with the moderately proteinuric group. We conclude that mild proteinuria late after renal transplantation is associated with a defect in glomerular charge selectivity. The development of nephrotic range proteinuria is associated also with a defect of glomerular size selectivity, which correlates with prominent glomerular pathology.
Infectious complications of lung transplantation. Impact of cystic fibrosis.
Authors: P A Flume, T M Egan, L J Paradowski, F C Detterbeck, J T Thompson, J R Yankaskas
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

It has been suggested that the presence of airway pathogens prior to lung transplantation (LT) in patients with cystic fibrosis (CF) may place these patients at a higher risk for infectious complications after LT. There is particular concern regarding patients colonized with multiresistant Pseudomonas, including P. cepacia, and fungi, including Aspergillus. We report our experience with LT for patients with CF and compare the results with those of patients with LT for other indications. Between January 1990 and March 1993, we performed LT for 27 patients with CF and 32 without CF. Nearly all (89%) of the patients with CF were colonized with P. aeruginosa; many were cultured with P. cepacia (19%) and Aspergillus (63%). The non-CF group rarely had organisms identified pre-LT. No patients with CF underwent pre-LT sinus drainage or received pre-LT treatment for Aspergillus. All of the patients received perioperative antibiotics and a standard regimen of immunosuppression and prophylactic antibiotics. The incidence of infectious complications was the same in the two groups; however, there was an association between obliterative bronchiolitis and pulmonary infections. One of the patients with CF with P. cepacia died as a result of this organism. None of the patients with CF required treatment for Aspergillus post-transplant. We conclude that patients with CF, despite the presence of airway pathogens, are at no greater risk of infectious complications after LT than are other patients.
Presence of lipid hydroperoxide in human plasma.
Authors: M A Warso, W E Lands
Journal: Journal of Clinical Investigation (1985)

Using purified prostaglandin (PG) H synthase, which synthesizes PGG2 and PGH2 from arachidonic acid, we were able to assay for the presence of peroxide activators in biological tissues. This assay system, capable of detecting both hydrogen peroxide (H2O2) and lipid hydroperoxides, detected a significant amount of synthase activator in plasma. Treatment of the active preparations with catalase and glutathione peroxidase showed that the principal activator in normal human plasma was a lipid hydroperoxide rather than H2O2.
Measles and Immune Globulin Prophylaxis for Travelers and Hepatitis A
Authors: Martin S. Wolfe
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 February 1990Measles and Immune Globulin Prophylaxis for Travelers and Hepatitis AMartin S. Wolfe, MDMartin S. Wolfe, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-3-235_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I fully agree with Drs. Hill and Pearson (1) that revaccination with measles vaccine is advisable for all travelers born in or after 1957 and is particularly important for travelers to areas of high endemicity for measles. These areas occur particularly in the developing world where hepatitis A transmitted via fecal contamination is also a high risk to nonimmune travelers. Hepatitis A can be protected against very well with an injection of immune globulin, which is usually given just before departure because of its relatively short half-life.According to the Centers for Disease Control recommendations for foreign...References1. HillPearson DR. Measles prophylaxis for international travel. Ann Intern Med. 1989;111:699-701. LinkGoogle Scholar2. Health Information for International Travel. Atlanta: Centers for Disease Control; 1989:71, 105. Google Scholar3. SzumnessDienstagPurcell WJR. Distribution of antibody to hepatitis A antigen in urban adult populations. N Engl J Med. 1976;295:755-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTraveling AbroadTravel Medicine and Travel Clinics 1 February 1990Volume 112, Issue 3Page: 235-235KeywordsGlobulinsHalf lifeHepatitis AMeaslesProphylaxisVaccines Issue Published: 1 February 1990 PDF downloadLoading ...
For a Medical Jury.
Authors: None Texas
Journal: JAMA (1894)

Brackettville, Texas, April 15, 1894. <h3>To the Editor:</h3> —I hasten to the support of the suggestion of your New York contributor (in No. 13 current volume) for a revision of the statutes in a manner to provide for "a jury of medical men in all cases where medical evidence is required." I would establish at least one such jury in every county. I would arraign for trial all professors of clinical morphology, wherever they may be found at large, and all speculators on the psycho-physical relations of man, whether in the East or West. I would not try them by rule of law, but simply attempt to find out what is the matter with them. "If it is the physician's business intelligently to treat disease, then here is a fine field for future development." The jury would be required to clear and determine such questions as this: What is the
George W Bush's second term
Authors: Martin McKee, Susan Foster
Journal: BMJ (2005)

Many domestic and international health policies are likely to be controversial 

W hen George W Bush returns to the White House after his inauguration ceremony, health is unlikely to be at the top of his agenda. In the months ahead he must devise strategies that will tackle record budget and trade deficits and pave the way for an exit from an increasingly unpopular war in Iraq. Yet many of the other decisions that he and his administration must make will have profound consequences for the health of America's people and for those in many other countries.

That the American healthcare system is in a mess has long been apparent. Despite spending vast and ever increasing amounts of money (now over a third more per person than Switzerland, the next highest spender), uniquely among industrialised countries the United States does not attempt to provide cover for all its citizens, and the number of uninsured people has increased from 42 million to 45 million in the past four years. Although …
Laparoendoscopic Excision of a Duodenal Mass
Authors: K. S. Gersin, B. T. Heniford, H. Baradi, J. L. Ponsky
Journal: Endoscopy (1999)

Large sessile lipomas, adenomas, and other tumors are often not amenable to endoscopic excision, due to the risk of bleeding or perforation. Resection of these lesions has traditionally required laparotomy with enterotomy for complete removal. A novel technique, described here, is the combination of laparoscopy and simultaneous endoscopy, allowing for complete removal of these lesions while preserving the benefits of minimally invasive surgery.
Computational Toxicology of Chloroform: Reverse Dosimetry Using Bayesian Inference, Markov Chain Monte Carlo Simulation, and Human Biomonitoring Data
Authors: Michael A. Lyons, Raymond S.H. Yang, Arthur N. Mayeno, Brad Reisfeld
Journal: Environmental Health Perspectives (2008)

One problem of interpreting population-based biomonitoring data is the reconstruction of corresponding external exposure in cases where no such data are available.
Omeprazole, Serum Gastrin, and Gastric Acid Suppression
Authors: R. Matthew Gideon
Journal: Annals of Internal Medicine (1995)

Letters1 February 1995Omeprazole, Serum Gastrin, and Gastric Acid SuppressionR. Matthew Gideon, MD, Vera Paoletti, MD, and Donald O. Castell, MDR. Matthew Gideon, MDThe Graduate Hospital, Philadelphia, PA 19146., Vera Paoletti, MDThe Graduate Hospital, Philadelphia, PA 19146., and Donald O. Castell, MDThe Graduate Hospital, Philadelphia, PA 19146.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-3-199502010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:It is well known that the decrease in gastric activity caused by omeprazole results in increased serum gastrin levels. We asked whether a precise relation exists between fasting serum gastrin levels and gastric acid suppression in patients receiving omeprazole. If such a relation exists, physicians could obtain fasting serum gastrin levels from their patients receiving omeprazole as a simple measure of the degree of gastric acid suppression. We used ambulatory intragastric pH monitoring to assess gastric acid suppression in 45 patients with gastroesophageal reflux who were receiving different doses of omeprazole. The pH probe was placed with ... Author, Article, and Disclosure InformationAffiliations: The Graduate Hospital, Philadelphia, PA 19146. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCOST-EFFECTIVE MANAGEMENT OF DYSPEPSIA AND GASTROESOPHAGEAL REFLUX DISEASE 1 February 1995Volume 122, Issue 3Page: 237-238KeywordsAntimonyGastrinGastroesophageal reflux diseaseRegression analysis Issue Published: 1 February 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 1313: Anti-tumorigenic effects of phenformin in human endometrial cancer cells
Authors: Amanda L. Jackson, Joshua E. Kilgore, Haifeng Qiu, Chunxiao Zhou, Paola A. Gehrig, Victoria L. Bae-Jump
Journal: Cancer Research (2014)

Abstract Introduction: The anti-diabetic drugs, metformin and phenformin, are thought to have anti-tumorigenic benefits. Preclinical studies suggest that phenformin may be more potent for inhibiting tumor growth than metformin. Our objective was to assess the anti-tumorigenic effects of phenformin in endometrial cancer (EC) cell lines and primary cultures. Methods: The EC cell lines, ECC-1 and Ishikawa, were treated with phenformin under low glucose (2 mM), normal glucose (5.5 mM) and high glucose (25 mM) conditions. EC tumors were collected from consenting patients, at the time of surgical staging for primary culture. Cell proliferation was assessed by MTT assay. Apoptosis was analyzed by Annexin V-FITC assay. Cellometer evaluated cell cycle progression. Invasion was demonstrated by transwell invasion assay. Adhesion was assessed by ELISA. Western blotting was performed to determine expression of the downstream targets of phenformin. Results: Phenformin inhibited proliferation in a dose-dependent manner in both EC cell lines, within 48-72 hrs of exposure (IC50=1 mM, p=0.0004-0.009). Inhibition of proliferation was seen for all glucose concentrations, but greater potency was observed under low glucose conditions. Treatment with phenformin resulted in G1 arrest, induction of apoptosis (p=0.022-0.017) and inhibition of adhesion (p=0.0053-0.0144) and invasion (p=0.0063-0.05). Phenformin increased p21 and p27 and decreased cyclin D, cyclin E2, CDK4 and CDK 6, corresponding with G1 arrest. Phenformin significantly inhibited proliferation in 62% (8/13) of the EC primary cultures, within 48-72 hrs of exposure (IC50 0.1-5mM, p=0.00001-0.016). 3 additional EC samples (23%) were significantly inhibited by phenformin but did not reach an IC50 (p=0.0003-0.018), and 2/13 (15%) had no response to phenformin. Western blot analysis demonstrated that phenformin increased phosphorylation of AMPK and decreased phosphorylation of S6 coincident with inhibition of proliferation in the EC cell lines and primary cultures. Conclusion: Phenformin potently inhibited cell growth via G1 arrest and induced apoptosis in EC cell lines and the majority of primary cultures. Inhibition of adhesion/invasion was also seen with phenformin. Continued work is needed to explore whether phenformin has superior benefits over metformin. Citation Format: Amanda L. Jackson, Joshua E. Kilgore, Haifeng Qiu, Chunxiao Zhou, Paola A. Gehrig, Victoria L. Bae-Jump. Anti-tumorigenic effects of phenformin in human endometrial cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1313. doi:10.1158/1538-7445.AM2014-1313
Human cytomegalovirus-induced immunosuppression. Relationship to tumor necrosis factor-dependent release of arachidonic acid and prostaglandin E2 in human monocytes.
Authors: M A Nokta, M I Hassan, K Loesch, R B Pollard
Journal: Journal of Clinical Investigation (1996)

Cytomegalovirus (CMV) has been associated with immunosuppression. Previously CMV was reported to interfere with signal transduction pathways in T cells. In this report the mechanisms underlying CMV-mediated immunosuppression were examined. Supernatants of CMV (Strains C-87, AD-169)-infected primary human monocyte (MO) cultures inhibited mitogenic T cell proliferative responses by > 95%. The inhibitory activity was observed 24 h through day 7 postinfection. The infection of MO was associated with a sustained elevation of intracellular levels of cAMP and the release of arachidonic acid (AA) and its metabolite PGE2 (activator of adenylate cyclase) in culture supernatants. The AA release was incidentally associated with TNF-alpha production. Monoclonal antibodies to TNF-alpha and pentoxyphylline (inhibitor of TNF synthesis) inhibited both AA and PGE2 release. The release of AA required protein synthesis and occurred under conditions consistent with the expression of CMV immediate early genes. Treatment of MO cultures at time of infection with 100 microM indomethacin or 1 microg of TNF-alpha mAb abolished the CMV-induced T cell inhibitory activity of the supernatants by 100%. These data suggest that TNF dependent release of AA and PGE2 contributes to CMV-induced immunosuppression.
Lymphocytic Choriomeningitis Virus — An Old Enemy up to New Tricks
Authors: C.J. Peters
Journal: New England Journal of Medicine (2006)

Lymphocytic choriomeningitis virus (LCMV) was among the first human pathogenic viruses to be isolated. In the mid-1930s, Armstrong and Lillie obtained a filterable agent thought to be from the brain of a man who died during an epidemic of St. Louis encephalitis, Traub discovered a chronic infection in a mouse colony, and Rivers and Scott isolated a virus from the cerebrospinal fluid of patients with aseptic meningitis (see image).1 All three of these viruses were shown to have the same properties and serologic features, and LCMV became the type species characterizing the virus family Arenaviridae, established in 1970. In nature, . . .
Doxycycline-Induced Phototoxicity
Authors: Thomas P Habif
Journal: New England Journal of Medicine (2006)

A 32-year-old man consulted his medical care provider in June because of persistent acne. Two months earlier he had been prescribed a benzoyl peroxide wash and doxycycline (100 mg twice daily). Four days after starting a new outdoor job, he noted burning and erythema on his cheeks, nose, and lips. The erythema intensified, blisters appeared on the lower lips, and the pain ranged from moderate to intense. Examination showed erythema on the face that was most intense on the cheeks, nose, and upper lip. The vermilion border of the lower lip appeared to have undergone impetiginization, with erosions and crusting. . . .
Heparin‐induced thrombocytopenia in myeloproliferative disorders: A rare or under‐diagnosed complication?
Authors: Galia Spectre, Yossi Kalish, Liliana Schliamser, David Varon
Journal: American Journal of Hematology (2008)

Abstract Patients with myeloproliferative disorders (MPD) are prone to develop thrombotic complications and thus frequently receive heparin. Surprisingly heparin‐induced thrombocytopenia (HIT) has been rarely reported in MPD and is potentially under‐diagnosed due to the relatively high platelet count. We report three patients with MPD who developed HIT; all presented with a relative fall of platelet counts (although without an absolute thrombocytopenia), thrombosis or skin necrosis and a positive test for HIT antibodies (particle gel immunoassay). Risk factors for developing HIT in our patients were exposure to unfractionated heparin, a recent surgical procedure and female gender. We review the literature on HIT in MPD and discuss the diagnosis of HIT in the absence of an absolute thrombocytopenia. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Mannose-Binding Lectin in Chronic Hepatitis B Virus Infection *
Authors: Wai Po Chong, Yuk Fai To, Wai Kee Ip, Man Fung Yuen, Tung Ping Poon, Wilfred H.S. Wong, Ching Lung Lai, Yu Lung Lau
Journal: Hepatology (2005)

Abstract Mannose binding lectin (MBL) is a pattern-recognition molecule of the innate immune system. The roles of MBL and its gene ( mbl2 ) polymorphisms, −221 X/Y and codon 54 A/B , in hepatitis B virus (HBV) infection were investigated in this study. We recruited 320 nonprogressed hepatitis B surface antigen (HBsAg) carriers; 199 progressed HBsAg carriers with hepatocellular carcinoma or cirrhosis; 87 spontaneously recovered individuals who were HBsAg negative and anti-HBs and anti HBc positive; and 484 controls who were naïve to HBV. There was no significant difference between nonprogressed carriers, spontaneously recovered individuals, and controls in terms of serum MBL levels and mbl2 polymorphisms distributions. However, the low MBL genotypes had a dose-dependent correlation with the cirrhosis and hepatocellular carcinoma in progressed carriers with odds ratios of 1.36 and 3.21 for the low and extremely low MBL genotypes, respectively ( P = .01). The low-expression promoter haplotype XA (OR = 1.97) and the mutant haplotype YB (OR = 1.90) were also associated with the cirrhosis and hepatocellular carcinoma ( P = .002). As expected, the lower serum MBL levels in progressed carriers as compared with nonprogressed carriers were due to an overrepresentation of low and extremely low MBL genotypes. Moreover, MBL could bind HBsAg in a dose- and calcium-dependent and mannan-inhibitable manner in vitro , suggesting that binding occurs via the carbohydrate recognition domains. This binding also enhanced C4 deposition. In conclusion , these results suggest that low MBL genotypes associate with the occurrence of cirrhosis and hepatocellular carcinoma in progressed HBsAg carriers, and MBL can bind HBsAg. (Hepatology 2005.)
Coverage With Evidence Development
Authors: Norman L. Foster, Karen Mottola, John M. Hoffman
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal