Protein-losing Enteropathy Complicating Prolonged Bleeding in Hemophilia
Authors: DAVID GREEN
Journal: Annals of Internal Medicine (1964)

Case Studies1 November 1964Protein-losing Enteropathy Complicating Prolonged Bleeding in HemophiliaDAVID GREEN, M.D., PHILIP H. GEISLER, M.D., ALLAN J. ERSLEV, M.D., F.A.C.P.DAVID GREEN, M.D.Search for more papers by this author, PHILIP H. GEISLER, M.D.Search for more papers by this author, ALLAN J. ERSLEV, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-928 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGastrointestinal bleeding is a dangerous and frequently fatal complication of hemophilia. In the series of Wilkinson, Nour-Eldin, Israels, and Barrett (1) there were 67 incidences of gastrointestinal (G.I.) bleeding in 229 patients requiring an average of 8.6 units of blood per incident. Hemorrhage from the alimentary tract ranked equally with intracranial bleeding as the major cause of death in these patients. Recently, emphasis has been placed on the use of Factor VIII concentrates in the control of this disease (2-6). In the present case, this approach was not satisfactory, and therapeutic efforts directed against a superimposed enteropathy coincided with the...References1. WILKINSONNOUR-ELDINISRAELSBARRETT JFFMCKE: Hemophilic syndromes. A survey of 267 patients. Lancet 2: 947, 1961. CrossrefMedlineGoogle Scholar2. MCMILLANDIAMONDSURGENOR CWLKDM: Treatment of classic hemophilia. Use of fibrinogen rich in Factor VIII for hemorrhage and for surgery. New Eng. J. Med. 265: 224, 277, 1961. CrossrefGoogle Scholar3. CREVELDVAN MOCHTAR SIA: Modern aspects of the treatment of hemophilia. Canad. Med. Ass. J. 87: 993, 1962. MedlineGoogle Scholar4. SALZMANGOULIAN EWM: Cholecystectomy and choledochostomy in a severe hemophilia. Ann. Surg. 156: 965, 1962. CrossrefMedlineGoogle Scholar5. IRWINLUTIESBLANCHARD ARWBRI: Bladder neck obstruction in a 6-months-old hemophilic infant. 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A controlled study during oral surgery. New Eng. J. Med. 266: 432, 1962. CrossrefMedlineGoogle Scholar18. BROWN J: Effect of steroids on metabolism of carbohydrate, protein and fat, in Clinical Uses of Adrenal Steroids, edited by BROWN, J., PEARSON, L. M., McGraw-Hill Co., New York, 1962, p. 403. Google Scholar19. GORDON RS: Exudative enteropathy. Lancet 1: 325, 1959. CrossrefMedlineGoogle Scholar20. SCHWARTZJARNUM HS: G.I. protein loss in idiopathic (hypercatabolic) hypoproteinemia. Lancet 1: 327, 1959. CrossrefMedlineGoogle Scholar21. MARSHAKWOLFCOHENJANOWITZ RHBSNHD: Protein-losing disorders of the gastrointestinal tract: roentgen features. Radiology 77: 893, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID GREEN, M.D.; PHILIP H. GEISLER, M.D.; ALLAN J. ERSLEV, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Charlotte Drake Cardeza Foundation, Jefferson Medical College, Philadelphia, Pa.Dr. Geisler died on July 9, 1964.Requests for reprints should be addressed to Allan J. Erslev, M.D., Jefferson Medical College, The Cardeza Foundation for Hematologic Research, 1015 Sansom St., Philadelphia, Pa. 19107. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySpontaneous intramural haematoma of the sigmoid colon causing acute intestinal obstruction in a haemophiliac: report of a caseFACTOR VIII ANTIBODIES: IMMUNOSUPPRESSIVE THERAPYSpontaneous Inhibitors of Factor VIIIProtein-losing Enteropathy and Intestinal Bleeding The Role of Lymphatic-Venous ConnectionsJOHN D. DAVIDSON, M.D., EDWARD P. FLYNN, M.D., JOEL B. KIRKPATRICK, M.D. 1 November 1964Volume 61, Issue 5_Part_1Page: 928-932KeywordsBloodEnteropathiesHemophiliaHemorrhageHypoproteinemiaProteins ePublished: 1 December 2008 Issue Published: 1 November 1964 PDF downloadLoading ...