A Proposed Trial of Amiodarone for Atrial Fibrillation
Authors: Larry E. Alves, Edward P. Rose
Journal: Annals of Internal Medicine (1992)

Letters1 December 1992A Proposed Trial of Amiodarone for Atrial FibrillationLarry E. Alves, MD, Edward P. Rose, MDLarry E. Alves, MDSearch for more papers by this author, Edward P. Rose, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-11-972 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: For several years, we have used low-dose amiodarone (≤ 200 mg/d) in the treatment of patients with supraventricular arrhythmias and have seen only minimal side effects (1). Use of low-dose amiodarone has also been advocated for the treatment of congestive heart failure in patients with severely impaired left ventricular function. We use the drug to prevent sudden death in patients with complex ventricular dysrhythmias with severely impaired left ventricular function (2).We agree with Middlekauff and colleagues that the time has come for a large-scale, long-term study in these patient groups.They indicated that hyperthyroidism necessitated cessation...References1. MiddlekauffWienerSaxonStevenson HILW. Low-dose amiodarone for atrial fibrillation. Time for a prospective study? Ann Intern Med. 1992;116:1017-20. LinkGoogle Scholar2. AlvesRose LE. Low dose amiodarone in congestive heart failure. J Am Coll Cardiol. 1992;17:1672-3. CrossrefGoogle Scholar3. AlbertAlvesRose SLE. Effects of amiodarone on serum lipoprotein levels. Am J Cardiol. 1991;68:259-61. CrossrefMedlineGoogle Scholar1. . The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. N Engl J Med. 1990; 323:1505-11. CrossrefMedlineGoogle Scholar2. . Preliminary report of the stroke prevention in atrial fibrillation study. N Engl J Med. 1990;322:863-8. CrossrefMedlineGoogle Scholar3. CoplonAntmanBerlinHewittChalmers SEJPT. Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. Circulation. 1990;82:1106-16. CrossrefMedlineGoogle Scholar4. HerreSauveMaloneGriffinHelmyLangberg JMPJIJ. Long-term results of amiodarone therapy in patients with recurrent sustained ventricular tachycardia or ventricular fibrillation. J Am Coll Cardiol. 1989;13:442-9. CrossrefMedlineGoogle Scholar5. . Preliminary report: effect of encainiade and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med. 1989;321:406-12. CrossrefMedlineGoogle Scholar1. MiddlekauffWienerSaxonStevenson HILW. Low-dose amiodarone for atrial fibrillation: Time for a prospective study? Ann Intern Med. 1992;116:1017-20. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Southern Illinois University Belleville, IL PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAmiodarone and the Development of ARDS After Lung Surgery 1 December 1992Volume 117, Issue 11Page: 972-973KeywordsArrhythmiaAtrial fibrillationDrugsHeart failureHyperthyroidismPatient advocacy Issue Published: 1 December 1992 PDF DownloadLoading ...