tbuckley/cabot-search huggingface dataset:
Expression Profiling Identifies Altered Expression of Genes That Contribute to the Inhibition of Transforming Growth Factor-β Signaling in Ovarian Cancer
Authors: Jan S. Sunde, Howard Donninger, Kongming Wu, Michael E. Johnson, Richard G. Pestell, G. Scott Rose, Samuel C. Mok, John Brady, Tomas Bonome, Michael J. Birrer
Journal: Cancer Research (2006)

Abstract Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-β (TGF-β); however, the mechanism of this resistance remains unclear. We used oligonucleotide arrays to profile 37 undissected, 68 microdissected advanced-stage, and 14 microdissected early-stage papillary serous cancers to identify signaling pathways involved in ovarian cancer. A total of seven genes involved in TGF-β signaling were identified that had altered expression &amp;gt;1.5-fold (P &amp;lt; 0.001) in the ovarian cancer specimens compared with normal ovarian surface epithelium. The expression of these genes was coordinately altered: genes that inhibit TGF-β signaling (DACH1, BMP7, and EVI1) were up-regulated in advanced-stage ovarian cancers and, conversely, genes that enhance TGF-β signaling (PCAF, TFE3, TGFBRII, and SMAD4) were down-regulated compared with the normal samples. The microarray data for DACH1 and EVI1 were validated using quantitative real-time PCR on 22 microdissected ovarian cancer specimens. The EVI1 gene locus was amplified in 43% of the tumors, and there was a significant correlation (P = 0.029) between gene copy number and EVI1 gene expression. No amplification at the DACH1 locus was found in any of the samples. DACH1 and EVI1 inhibited TGF-β signaling in immortalized normal ovarian epithelial cells, and a dominant-negative DACH1, DACH1-ΔDS, partially restored signaling in an ovarian cancer cell line resistant to TGF-β. These results suggest that altered expression of these genes is responsible for disrupted TGF-β signaling in ovarian cancer and they may be useful as new and novel therapeutic targets for ovarian cancer. (Cancer Res 2006; 66(17): 8404-12)
Differences In The Immunologic Response To Peanut Allergen Depending Upon The Route, Lipid Content And Peanut Roasting In An Animal Model
Authors: M.M. Ferrer, C. Gamazo, J. Irache, S. Gomez, M. Sanz, G. Gastaminza, V. del Pozo, M. Goikoechea, J. de Souza
Journal: Journal of Allergy and Clinical Immunology (2010)
S5 Variability in clinician’s perception regarding fitness to drive in patients with Obstructive sleep apnoea syndrome (OSAS)- on behalf of the british thoracic society sleep apnoea SAG.
Authors: A Dwarakanath, D Ghosh, SL Jamson, PD Baxter, M Twiddy, MW Elliott
Journal: Thorax (2013)

<h3>Introduction</h3> Advice about driving is a key component of the management of OSAS patients. No objective tests have been shown to predict reliably whether an individual is safe to drive or not and therefore the advice given will depend upon the opinion of clinicians. We evaluated the current practice of advice given regarding fitness to drive in OSAS patients. <h3>Methods</h3> Clinicians were invited to participate in a web-based survey. The questionnaire included six clinical vignettes describing a variety of OSAS patients. For each the respondent chose from options ranging from driving without restriction to advising not to drive at all. For ease of presentation the data are summarised as whether would allow driving or not. <h3>Results</h3> 467 respondents completed the survey. The advice given by the respondents to various clinical vignettes was variable (figure-1). In the least contentious scenario (vignette-1) there was 1 in 14.6 chance and in the most (vignette-4) there was a 1 in 2 chance of an individual being told whether they could drive or not. Respondents were more likely to advise patients to refrain from driving if the AHI was worse (P- &lt; 0.0001, OR-3.9), if the Epworth sleepiness score was high (P-&lt; 0.0001, OR-23.5) and if the patient admitted to any problems at all while driving (P- 0.0098, OR-1.6). Males were more likely to allow OSAS patients to drive. Consultants without an interest in sleep medicine and respondents seeing less than 5 patients per month were more likely to advise against driving. The advice given was not related to the age of the clinician. <h3>Conclusions</h3> This survey has shown that there is considerable variability in the advice given by clinicians, with in some situations a patient having an even chance of receiving opposite advice, depending on who they see. Restriction of driving has major implications for an individual, both social and financial. Allowing someone to drive who is not safe to do so has potentially disastrous consequences for them and others. The issue of how to improve consistency of advice needs to be addressed.
Hepatitis and Leukemia
Authors: ANTONIO JULIÁ
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 November 1980Hepatitis and LeukemiaANTONIO JULIÁ, M.D., LORENZO FONT, M.D.ANTONIO JULIÁ, M.D.Search for more papers by this author, LORENZO FONT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-5-780 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In Barton and Conrad's article (1) in the February 1979 issue there is an implication that hepatitis may have a beneficial effect in acute myelogenous leukemia. Several letters expressed concern for the conclusions in this article but did not provide evidence against the reasoning.We decided to review our own experience to ascertain the effect of the increase in serum glutamic-oxalacetic transaminase (SGOT) on survival in patients with acute myelogenous leukemia and compared the results with those obtained by Barton and Conrad.We reviewed the records of 52 adult patients, seen at our institution during the last...Reference1. BARTONCONRAD JM. Beneficial effects of hepatitis in patients with acute myelogenous leukemia. Ann Intern Med. 1979;90:188-90. LinkGoogle Scholar1. BARTONCONRAD JM. Beneficial effects of hepatitis in patients with acute myelogenous leukemia. Ann Intern Med. 1979;90:188-90. LinkGoogle Scholar2. BARTONCONRAD JM. Prognostic significance of hepatitis in acute myelogenous leukemia. Clin Res. 1979;27:490A. Abstract. Google Scholar3. ARMITAGEBURNSKENT JCT. Liver disease complicating the management of acute leukemia during remission. Cancer. 1978;41:737-42. CrossrefMedlineGoogle Scholar4. WERNERLONDON BW. Host responses to hepatitis B infection: hepatitis B surface antigen and host proteins. Ann Intern Med. 1975;83:113-4. LinkGoogle Scholar5. HERSHGUTTERMANMAVLIGIT EJG. Serial studies of immunocompetence of patients undergoing chemotherapy for acute leukemia. J Clin Invest. 1974;54:401-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ciudad Sanitaria del Valle de Hebron Barcelona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byViral Hepatitis in the Compromised HostBleomycin-reactive iron in patients with acute non-lymphocytic leukemiaViral Hepatitis in the Compromised HostAdverse prognostic influence of hepatitis b virus infection in acute lymphoblastic leukemiaIntestinal and Hepatic Complications of Human Bone Marrow Transplantation. Part IIIntestinal and hepatic complications of human bone marrow transplantation. Part IPrognosis of Acute Myelogenous LeukemiaJUAN JOSÉ LAHUERTA-PALACIOS, SANTIAGO LARREGLA-GARRAUS, FRANCISCO FERNÁNDEZ-DEBORA, RICARDO RUIZ DE ADANA 1 November 1980Volume 93, Issue 5Page: 780-780KeywordsAcute myeloid leukemiaAminotransferasesHepatitis AReasoningSerum glutamic oxaloacetic transaminase Issue Published: 1 November 1980 PDF downloadLoading ...
SPECKLE TRACKING IS A ROBUST METHOD TO EVALUATE DYNAMIC FUNCTION OF THE HEART: AN IN-VITRO MODEL STUDY
Authors: David Sahn, Galyna Kovch, Shahryar Ashraf, Sarah Keunju Yang, Sheetal Krishnakumar, Anugraha Rajendran, Nicole Chang, Grace Wang
Journal: Journal of the American College of Cardiology (2015)
New Observations on Body Organ Language
Authors: Christian Müller
Journal: Psychotherapy and Psychosomatics (1984)

Application of the electromesenterography (<i>Busset</i>, Paris) combined with the alamograph of <i>Spindel</i>. Comparison of a randomized normal group (students) with a matched group of pheneropoly syndrome. The results seem to confirm the early Freudian hypothesis of organ language.
THE CHEMISTRY OF CEREBROSPINAL FLUIDS.
Authors: TORALD SOLLMANN
Journal: JAMA (1903)

During the last few years I have examined a number of cerebrospinal fluids from lumbar punctures. The analyses are of some interest, as they throw light on such disputed questions as the molecular concentration and the nature of the proteids. In other respects they may serve to enlarge somewhat the already existing knowledge of this fluid. The specimens were usually not analyzed until a day or two after they were drawn, but they were received and preserved in sterile flasks, kept very cold. The first four cases were furnished by Dr. C. J. Aldrich, from patients with febrile temperatures. The last fluid was given me by Dr. C. E. Briggs. I wish to take this opportunity of thanking these gentlemen for the material. <h3>SUMMARY OF ANALYSES.</h3> The results of the analyses are briefly as follows: <h3>Appearance.</h3> —Fluids I to IV, are perfectly clear and colorless, III containing a very small
Hot-Film Anemometer Velocity Measurements of Arterial Blood Flow in Horses
Authors: ROBERT M. NEREM, JOHN A. RUMBERGER, DAVID R. GROSS, ROBERT L. HAMLIN, GARY L. GEIGER
Journal: Circulation Research (1974)

Blood velocity measurements were carried out using a constant-temperature hot-film anemometer system in both anesthetized and conscious horses. Catheter probes were used to measure velocity wave forms in conscious horses and L-shaped needle probes inserted by direct vessel puncture were used to measure the profiles in regions of the thoracic and abdominal aorta of anesthetized, open-chest horses. Both catheter and L-shaped probes were used for coronary velocity wave-form measurements. The flow conditions were characterized by peak Reynolds numbers of 200-10,000 and unsteadiness parameter of 2-30. These measurements indicate that in the thoracic aorta the flow at peak systole is largely inviscid with a thin-wall boundary layer; in the abdominal aorta the flow is more fully developed but skewed due to branching effects. Highly disturbed flows were observed in the thoracic aorta of both anesthetized and conscious horses, but not in the abdominal aortic region or in the coronary arteries. The results of this study indicate that the flow in the arterial system, although in many cases laminar and disturbance free, is extremely varied in character. It may be asymmetric and certainly is not representative of fully developed, Poiseuille flow.
P2-145: Reduction of non small cell lung cancer (NSCLC) cell line migration in vitro by inhibition of the CXCR4/SDF-1 axis; a novel approach to preventing dissemination of early stage NSCLC.
Authors: Shannon Otsuka, Yu Ding, Huong Muzik, Don Morris, Gwyn Bebb
Journal: Journal of Thoracic Oncology (2007)
IL-17–producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression
Authors: Pierre Milpied, Bérangère Massot, Amédée Renand, Séverine Diem, André Herbelin, Maria Leite-de-Moraes, Marie-Thérèse Rubio, Olivier Hermine
Journal: Blood (2011)
P1-03-05: Fibrocystic Changes Have Different Age-Dependent Patterns in Benign, In Situ, and Invasive Breast Cancer Patients.
Authors: A Bekhash, AJ Kovatich, Y Chen, JA Hooke, L Kvecher, RJ Mural, CD Shriver, H Hu
Journal: Cancer Research (2011)

Abstract Background: Fibrocystic changes (FCCs) have been known to develop in the aging process. Breast cancers in younger and elderly women are known to have different characteristics. Less is known about alterations in the microenvironment for disease development in middle-aged women who undergo menopausal changes. The Walter Reed Army Medical Center, through the Clinical Breast Care Project, has enrolled over 2000 subjects undergoing a biopsy; all the pathology was reviewed by a single pathologist. These subjects provide an opportunity to study the age-dependent pattern of FCC across benign, in situ (IS) and invasive breast carcinoma (IBC) patient populations. Methods: Subjects were enrolled following IRB-approved protocols. A total of 2060 subjects were identified for this study, including 1226 benign/atypical, 193 IS, and 641 IBC patients. Patients were divided into three age groups: &amp;lt;=45 years, 46–65 years, and &amp;gt;=66 years. Chi-Square test in the SAS was used for statistical analysis across the age groups for the occurrence of FCCs. For IS and IBC patients, additional analysis was performed on high grade (grade 3) and non-high grade (grades 1 and 2 combined) cancers. For IS, grade analysis was performed on ductal carcinoma (DCIS). Results: As shown in the Table, FCC occurrence rate is significantly lower in younger patients in the benign population. In the IBC population, this rate is significantly higher in middle-aged patients. This higher rate is significant in the non-high grade patients but disappears in the high grade patients. In the IS population, the same trend exists that the FCC rate is higher in middle-aged patients. This trend is retained in non-high grade DCIS but again lost in high grade DCIS. Discussion: The observation that FCC increases with age in the benign population, but is bell-shaped in IBC and IS populations, supports a hypothesis that physiological changes in the middle-aged women may alter the microenvironment for disease development. The observation that the bell-shaped pattern is due to non-high grade DCIS but not due to high-grade DCIS suggests that changes in the microenvironment contribute to breast disease development. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-03-05.
Charges for Hospital Care
Authors: BRUCE HECKMAN
Journal: Annals of Internal Medicine (1974)

Comments1 November 1974Charges for Hospital CareBRUCE HECKMAN, M.D.BRUCE HECKMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-5-712_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the July 1974 issue, Lyle and co-workers attempted to estimate costs in a private internal medicine group practice. Simple calculations from Table 4 show that the average physician daily charges for hospital care are $12.70 per day (see below), not $10.00 as stated in the article. This amounts to an understatement by 21%.There is an obvious lack of internal reproducibility of calculations. I cannot see how such inaccuracy can be condoned. The importance of this potentially valuable paper is tremendously lessened. I hope it is not used as an example of costs or in cost-benefit... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 14 Church Street Ossining, New York 10562 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1974Volume 81, Issue 5Page: 712-713KeywordsHospital medicineReproducibility Issue Published: 1 November 1974 PDF DownloadLoading ...
SPECT With In-111 Autologous Platelets to Detect Residual Splenic Tissue in Two Patients With Relapsed Thrombocytopenia
Authors: KAZUYOSHI SUGA, KAZUYA NISHIGAUCHI, KENSAKU SHIMIZU, NORIHIKO KUME, NAOFUMI MATSUNAGA, YASUYUKI SATO, AKIRA TANGOKU, NAWATA KOUICHI, KENSUKE ESATO
Journal: Clinical Nuclear Medicine (1997)

In two patients with relapsed thrombocytopenia, the authors used SPECT with In-111 labeled autologous platelets to identify residual splenic tissue after splenectomy. One case involved a previously splenectomized patient with idiopathic portal hypertension, while the other had relapsed chronic idiopathic thrombocytopenic purpura(ITP). In both patients, SPECT showed a higher In-111 uptake in the splenic tissues compared with planar images. In the patient with ITP, a small accessory spleen had been overlooked on abdominal CT because of postoperative changes, but it was identified by superimposition of SPECT/CT images. These cases indicate that In-111 platelet SPECT is useful in detecting and localizing residual accessory splenic tissue associated with relapsed thrombocytopenia.
India targets 243 million adolescents in new health strategy
Authors: T. Biswas
Journal: BMJ (2014)

India has launched a national health programme aimed at improving the status of adolescent health in the country. Known as Rashtriya Kishor Swasthya Karyakram (RKSK), the programme is expected to benefit 243 million adolescents aged 10-19 years across the country.

RKSK aims to reach all adolescents in the age group irrespective of their sex, place of residence, whether in or out of school, or whether married or unmarried. 

The …
Patient-satisfaction survey in general practice.
Authors: P R Kaim-Caudle, G N Marsh
Journal: BMJ (1975)

A paper published in the British Medical J7ournal in February 19741 reported on the work load of a Teesside general practice in 1972. The doctor held an average of 2-3 consultations per patient per year and his attendance :visit ratio was 5:1. The overall average consultation rate for the team of doctor, nurse and health visitor was 3-1 with an attendance:visit ratio of 2*9 :1. The number of home visits in the practice of 3100 patients was 2500 and these were shared about equally by the doctor and the nurse. The work load (items of service rendered) in that practice was substantially less than the national average. The Royal College of General Practitioners estimated that the average general practitioner consultation rate in the 1960s was about 4.02 and that the attendance:visit ratio was about 4:1.3 The findings of the General Household Survey4 for 1971 suggest that the average consultation rate in the northern region, which includes Teesside, is much the same as that for Great Britain. The age composition of the Teesside practice differed somewhat from the national average but these differences (on the basis of the regional age-specific consultation rates of the General Household Survey) should not have affected significantly the overall consultation rate. The paper' concluded, Given a desire to reduce and rationa lize work load, given an attitude that patients should monitor the care of their own short-term illnesses, given a delegation orientated doctor and a team of readily available paramedical workers whose facilities are excellent, given a clinically confident and experienced general practitioner who does not devalue or minimize the training, experience, and ability of the members of the team, given a known group of patients, and even given an attitude which avoids hospital referral rather than seeks it, it would appear that even in a high morbidity and high mortality area, the work load of a general practitioner can become small. . . . The average list size of 2400 patients will rapidly become too small to occupy the time of established general practitioners. We report here the findings of a patient-satisfaction survey which aimed to discover the reaction of patients to a style of primary medical care which results in a low work load for the doctor. Method
Late presentation of HIV disease and its associated factors among newly diagnosed patients before and after abolition of a government policy of mass mandatory screening
Authors: Pyoeng Gyun Choe, Wan Beom Park, Jin Su Song, Nak-Hyun Kim, Jin Yong Park, Kyoung-Ho Song, Sang Won Park, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh
Journal: Journal of Infection (2011)
PLASMA GALECTIN-3 LEVELS PREDICT LEFT VENTRICULAR REMODELLING DETERMINED BY SEQUENTIAL ECHOCARDIOGRAPHY: RESULTS FROM THE DEVENTER-ALKMAAR HEART FAILURE STUDY
Authors: Dirk Lok, Peter van der Meer, Pieta Bruggink Andre de la Porte, Eric Lipsic, Jan van Wijngaarden, Yigal Pinto, Dirk Jan van Veldhuisen
Journal: Journal of the American College of Cardiology (2010)
Effect of alveolar lining material-coated silica on rat alveolar macrophages.
Authors: R J Emerson, G S Davis
Journal: Environmental Health Perspectives (1983)

The disparity between in vitro silica cytotoxicity toward macrophages and their in vivo resistance to injury following inhalation of silica at physiologic concentrations is unresolved. It is probable that inhaled silica particles absorb a variety of biological substances including proteins and alveolar lining material (ALM) thus altering the in vivo response of the macrophage to these particles. Silica (SI) particles coated with rat ALM and uncoated SI particles were studied for their ability to injure rat alveolar macrophages (AM) in vitro. Suspensions of particles were tested at concentrations from 0 to 400 micrograms per 2 X 10(6) cells. Cytotoxicity was assessed by the percent of total cellular lactate dehydrogenase (LDH) released by AM into the culture medium during incubation. Comparable physical association by ALM-coated and uncoated SI particles with AM was shown by scanning electron microscopy combined with X-ray energy spectrometry. These data show that SI coated with ALM is effectively phagocytosed by AM in vitro but is much less cytotoxic than uncoated SI. The surfactant lipids which presumably coat inhaled SI particles in the lung may reduce or delay their toxicity for AM.
Barry Miller replies to Des Spence
Authors: B. Miller
Journal: BMJ (2010)

I suspect that I am not alone in being concerned about the opinions of Dr Des Spence in his recent article revisiting pain and its treatment.1 2

I take issue with six of his most recent assertions.1

This figure is well recognised—for example, a recent report claimed 19% on the basis of interviews with 46 000 people across Europe.3

The standard definition is a pain occurring more than twice a week for more than 6 months and of a severity of more than 5/10. It is a point prevalence, and will include people whose duration of pain is limited, but it clearly describes an …
Diagnosis of a Sadness at the Heart With Therapeutic Intent
Authors: JEREMY NOBEL
Journal: Annals of Internal Medicine (1983)

Ad Libitum1 January 1983Diagnosis of a Sadness at the Heart With Therapeutic IntentJEREMY NOBEL, M.D.JEREMY NOBEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-116 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerptfor MatthewCover one eye.How many fingers am I holding up?Cover one ear.Can you hear my watch ticking?Can you hear me whisper?Cover the other eye.Cover the other ear.Cover both eyes.Can you see where you were born?Can you see the love living things have for each other and for themselves.Can you see whom you have to forgive?Can you see that the colors in your world are your decisions to be too afraid?Yes, they seem to be working.Cover both ears.Can you hear your loneliness?Can you hear the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1983Volume 98, Issue 1Page: 116-116KeywordsHeart Issue Published: 1 January 1983 PDF downloadLoading ...