Lymphomatous Leptomeningitis as a Presenting Syndrome of Hodgkin's Disease
Authors: PETER G. STEINHERZ
Journal: Annals of Internal Medicine (1983)

Brief Reports1 September 1983Lymphomatous Leptomeningitis as a Presenting Syndrome of Hodgkin's DiseasePETER G. STEINHERZ, M.D., RUSSELL WALKER, M.D., GEORGE KROLL, M.D., PHILIP EXELBY, M.D., LAUREL J. STEINHERZ, M.D., MARY WEISER, R.N., DENIS MILLER, M.D.PETER G. STEINHERZ, M.D.Search for more papers by this author, RUSSELL WALKER, M.D.Search for more papers by this author, GEORGE KROLL, M.D.Search for more papers by this author, PHILIP EXELBY, M.D.Search for more papers by this author, LAUREL J. STEINHERZ, M.D.Search for more papers by this author, MARY WEISER, R.N.Search for more papers by this author, DENIS MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-3-342 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with Hodgkin's disease may have neurologic symptoms without tumor involvement, or the disease may extend into the nervous system. Intracerebral disease is uncommon (1, 2). Meningeal disease occurs rarely as a terminal complication of long-standing disease. Eleven cases have been reported (3-10). Meningeal disease before diagnosis of systemic disease has been reported once (11). We report the case of a patient who presented with progressive weakness, paresthesias, pain, papilledema, and polyradiculopathy. Myelographic examination showed several root involvements with no epidural disease.A 16-year-old man had a 9-kg weight loss. Findings in the physical examination were normal. Fatigue and progressive...References1. MARSHALLROESSMANVAN DEN NOORT GUS. Invasive Hodgkin's disease of brain: report of two new cases and review of American and European literature with clinical-pathologic correlations. Cancer. 1968;22:621-30. CrossrefMedlineGoogle Scholar2. CUTTERMEYERHUANG JRY. Intracerebral involvement in Hodgkin's disease: a report of 6 cases and review of the literature. Cancer. 1979;43:1497-506. CrossrefMedlineGoogle Scholar3. LASCELLESBURSTON RJ. Hodgkin's disease: disease presenting with symptoms of cranial nerve involvement. Arch Neurol. 1962;7:359-64. CrossrefGoogle Scholar4. GRIFFINTHOMPSONMITCHINSONDE KIEWIETWELLAND JRMJF. Lymphomatous leptomeningitis. Am J Med. 1971;51:200-8. CrossrefMedlineGoogle Scholar5. COURTENAY EVANSMCELWAIN RT. Eosinophilic meningitis in Hodgkin's disease. Br J Clin Pract. 1969;23:382-4. MedlineGoogle Scholar6. STRAYERBENDER DR. Eosinophilic meningitis complicating Hodgkin's disease: a report of a case and review of the literature. Cancer. 1977;40:406-9. CrossrefMedlineGoogle Scholar7. CERVANTESMONTSERRATROZMAN FEC. Eosinophilic meningitis in Hodgkin's disease [Letter]. Ann Intern Med. 1979;91:930. Google Scholar8. PATCHELLPERRY RM. Eosinophilic meningitis in Hodgkin's disease. Neurology. 1981;31:887-8. CrossrefMedlineGoogle Scholar9. DILLMANMUEHGRECOGREEN RJCM. Leptomeningeal Hodgkin's disease [Letter]. Ann Intern Med. 1980;92:714-5. LinkGoogle Scholar10. POSNERCHERNIK JN. Intracranial metastases from systemic cancer. Adv Neurol. 1978;19:579-92. MedlineGoogle Scholar11. KAUFMAN G. Hodgkin's disease involving the central nervous system. Arch Neurol. 1965;13:55-8. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memorial Sloan-Kettering Cancer Center New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHodgkin's disease of the thoracic vertebraeIsolated, Primary Spinal Epidural Hodgkin's Disease in a ChildPrimary intradural extraarachnoid Hodgkin lymphoma of the cervical spineHodgkin's Lymphoma: Diagnosis and TreatmentIsolated, Primary Extranodal Hodgkin's Disease of the Spine: Case ReportIsolated, Primary Extranodal Hodgkin’s Disease of the Spine: Case ReportHodgkin's disease with spinal cord compression. A case report and a review of the literatureLetter: Is Central Nervous System Involvement in Hodgkin's Disease Really Very Rare?Craniocerebral involvement in lymphomaCase 8-1990A case of vogt-koyanagi-harada syndrome in a patient affected by hodgkin's diseaseA 42-Year-Old Male with Recent-Onset DementiaIntramedullary spinal cord metastasis in Hodgkin's disease: Rapid diagnosis and treatment resulting in neurologic recoveryHODGKIN'S DISEASE PRESENTING WITH CENTRAL NERVOUS SYSTEM INVOLVEMENTHodgkin's disease presenting with isolated craniospinal involvementReferencesLes méningites chroniques: un carrefour à baliser analyse de 5 observations et revue de la littérature 1 September 1983Volume 99, Issue 3Page: 342-343KeywordsFatigueHodgkin lymphomaNervous systemSystemic diseasesWeight loss Issue Published: 1 September 1983 PDF DownloadLoading ...