Lovastatin, Pravastatin, and Serum Lipoprotein(a)
Authors: Bernd G. Jacob
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 May 1990Lovastatin, Pravastatin, and Serum Lipoprotein(a)Bernd G. Jacob, MD, Werner O. Richter, MD, Peter Schwandt, MDBernd G. Jacob, MDSearch for more papers by this author, Werner O. Richter, MDSearch for more papers by this author, Peter Schwandt, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-9-713_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Genetically determined high concentrations of lipoprotein(a) [Lp(a)] have been strongly associated with premature cardiovascular disease (1), myocardial infarction (2), and cerebrovascular disease (3) in men. Until now, none of the classic hypolipidemic drugs has clearly been shown to influence this risk factor (4). There are controversial findings regarding the new class of HMG-CoA (3-hydroxy-3-methylglutarylcoenzymeA) reductase inhibitors. Berg and Leren (5) reported unchanged serum Lp(a) concentrations in 30 patients with familial hypercholesterolemia treated with lovastatin, whereas Jürgens and colleagues (6) found an increased Lp(a) level during treatment with lovastatin in 8 patients. We therefore studied the effect...References1. DahlenGuytonAttarFarmerKautzGotto GJMJJA. Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography. Circulation. 1986;74:758-65. CrossrefMedlineGoogle Scholar2. RhoadsDahlenBergMortonDannenberg GGKNA. Lp(a) lipoprotein as a risk factor for myocardial infarction. JAMA. 1986; 256:2540-4. CrossrefMedlineGoogle Scholar3. MuraiMiyaharaFujimotoMatsudaKameyama ATNMM. Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction. Atherosclerosis. 1986;59:199-204. CrossrefMedlineGoogle Scholar4. KostnerKleinKrempler GGF. Can serum Lp(a) concentrations be lowered by drugs and/or diet? In: Carlson LA, Olsson AG, eds. Treatment of Hyperlipoproteinemia. New York: Raven Press; 1984: 151-6. Google Scholar5. BergLeren KT. Unchanged serum lipoprotein(a) concentrations with lovastatin [Letter]. Lancet. 1989;2:812. CrossrefMedlineGoogle Scholar6. JürgensAshyZenker GAG. Raised serum lipoprotein during treatment with lovastatin [Letter]. Lancet. 1989;1:911-2. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Bernd G. Jacob, MD; Werner O. Richter, MD; Peter Schwandt, MDAffiliations: University of Munich 8000 Munich 70 Federal Republic of Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEfecto del etofibrato de liberación sostenida en pacientes con concentraciones plasmáticas de lipoproteína(a) > 300 mg/lMANAGEMENT OF HYPERCHOLESTEROLEMIAMANAGEMENT OF HYPERCHOLESTEROLEMIAChanges in serum lipoprotein(a) in hyperlipidemic subjects undergoing long-term treatment with lipid-lowering drugsLipoprotein(A): Physiologic Function, Association with Atherosclerosis, and Effects of Lipid-Lowering Drug TherapyIon Exchange ResinsDrug treatment of dyslipoproteinemiaLipoprotein[a] as a risk factor for preclinical atherosclerosis.A multicenter comparative trial of lovastatin and pravastatin in the treatment of hypercholesterolemiaApolipoprotein(a) polymorphism predicts the increase of Lp(a) by pravastatin in patients with familial hypercholesterolaemia treated with bile acid sequestrationDrug therapy of hyperlipidemiaSerum Lp(a) concentrations are unaffected by treatment with the HMG-CoA reductase inhibitor Pravastatin: results of a 2-year investigation 1 May 1990Volume 112, Issue 9Page: 713-714KeywordsAttentionCardiovascular diseasesCerebrovascular diseasesDrugsFamilial hypercholesterolemiaMedical risk factorsMyocardial infarction ePublished: 1 December 2008 Issue Published: 1 May 1990 PDF downloadLoading ...