Prophylaxis for Toxoplasmosis in AIDS
Authors: Miles H. Beaman, Benjamin J. Luft, Jack S. Remington
Journal: Annals of Internal Medicine (1992)

Editorials15 July 1992Prophylaxis for Toxoplasmosis in AIDSMiles H. Beaman, MBBS, Benjamin J. Luft, MD, Jack S. Remington, MDMiles H. Beaman, MBBSSearch for more papers by this author, Benjamin J. Luft, MDSearch for more papers by this author, Jack S. Remington, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-2-163 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptToxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome (AIDS) may result in death even when treated (1). In patients with AIDS, toxoplasmic encephalitis is almost always a reactivation of a pre-existing latent infection (1), most often occurring when the total CD4 count falls below 100 cells/mm-3(2). Persons at risk can be identified by screening human immunodeficiency virus (HlV)-positive patients for antibody toToxoplasma gondii. Seroprevalence varies considerably in the general population, ranging from 96% in Western Europe to 10% to 40% in the United States (3). Of those patients with AIDS who are...References1. LuftRemington BJ. Toxoplasmic encephalitis. Clin Infect Dis. 1992;[In press]. CrossrefMedlineGoogle Scholar2. DannemannMcCutchanIsraelskiAntoniskisLeportLuft BJDDCB. Treatment of toxoplasmic encephalitis in patients with AIDS: A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfonamides. Ann Intern Med. 1992;116:33-43. LinkGoogle Scholar3. IsraelskiRemington DJ. AIDS-associated toxoplasmosis. In: Sande MA, Volberding PA; eds. The Medical Management of AIDS, 3rd edition. Philadelphia: W.B. Saunders; [In press]. Google Scholar4. ZangerleAllerbergerPohlFritschDierich RFPPM. High risk of developing toxoplasmic encephalitis in AIDS patients seropositive to Toxoplasma gondii. Med Microbiol Immunol. 1991;180:59-66. CrossrefMedlineGoogle Scholar5. 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