Canine Models for Ventricular Tachyarrhythmia
Authors: ERIC L. MICHELSON
Journal: Annals of Internal Medicine (1981)

Editorials1 November 1981Canine Models for Ventricular TachyarrhythmiaERIC L. MICHELSON, M.D.ERIC L. MICHELSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-5-648 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent advances in clinical electrophysiology have been considerable. With sophisticated intracardiac recording and programmed pacing, cardiologists can initiate, terminate, and elucidate the apparent mechanisms of complex cardiac arrhythmias, which had been items of great academic interest but also sources of frustration for concerned practitioners. Given the potential of clinical electrophysiology, the question now arises: Where do we go next?The major challenge to electrophysiologists is how to channel recent advances in pharmacology, cardiovascular surgery, and pacemaker technology (including implantable automatic defibrillators) into preventing sudden cardiac death. Clinical electrophysiologists already have accumulated considerable experience in patients susceptible to sustained ventricular tachycardia...References1. HOROWITZJOSEPHSONFARSHIDISPIELMANMICHELSONGREENSPAN LMASEA. Recurrent sustained ventricular tachycardia: 3. Role of the electrophysiologic study in selection of antiarrhythmic regimens. Circulation. 1978;58:986-97. CrossrefMedlineGoogle Scholar2. RUSKINDIMARCOGARAN JJH. Out-of-hospital cardiac arrest: electrophysiologic observations and selection of long-term antiarrhythmic therapy. N Engl J Med. 1980;303:607-13. CrossrefMedlineGoogle Scholar3. MASONWINKLE JR. 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Electrophysiologic actions of UM-272 (pranolium) on reentrant ventricular arrhythmias in post-infarction canine myocardium. J Pharmacol Exp Therap. 1980;214:347-53. MedlineGoogle Scholar17. GARANFALLONRUSKIN HJJ. Sustained ventricular tachycardia in recent canine myocardial infarction. Circulation. 1980;62:980-7. CrossrefMedlineGoogle Scholar18. MICHELSONSPEARMOORE EJE. Strength-interval relations in a chronic canine model of myocardial infarction. Circulation. 1981;63:1158-64. CrossrefMedlineGoogle Scholar19. MICHELSONSPEARMOORE EJE. Description of chronic canine myocardial infarction models suitable for the electropharmacologic evaluation of new antiarrhythmic drugs. In: MORGANROTH J, MOORE EN, DREIFUS LS, MICHELSON EL, eds. The Evaluation of New Antiarrhythmic Drugs. The Hague, the Netherlands: Martinus Nijhoff Publishers; 1981:33-46. CrossrefGoogle Scholar20. LUCCHESIHOLLANDPATTERSON BKE. Ventricular fibrillation resulting from ischemia at a distant site in a conscious canine model of sudden coronary death. Fed Proc. 1981;40:646. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERIC L. MICHELSON, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Efficacy of Cibenzoline in Preventing PES Induction of Ventricular Tachycardia in the DogIdentification of reproducible ventricular tachycardia in a canine modelNature of inducible ventricular tachyarrhythmias in a canine chronic myocardial infarction modelRecent Advances in Antiarrhythmic Drug Research: Studies in Chronic Canine Myocardial Infarction-Ventricular Tachyarrhythmia Models 1 November 1981Volume 95, Issue 5Page: 648-649KeywordsCardiac electrophysiologyCardiac surgeryElectrophysiologistsHeartLungsPacemakersPharmacologySudden cardiac deathTachycardiaVentricular tachycardia ePublished: 1 December 2008 Issue Published: 1 November 1981 PDF downloadLoading ...