Colchicine Suppression of Local and Systemic Inflammation Due to Calcinosis Universalis in Chronic Dermatomyositis
Authors: JAMES TABORN
Journal: Annals of Internal Medicine (1978)

Brief Reports1 November 1978Colchicine Suppression of Local and Systemic Inflammation Due to Calcinosis Universalis in Chronic DermatomyositisJAMES TABORN, M.D., GILES G. BOLE, M.D., F.A.C.P., GEORGE R. THOMPSON, M.D., F.A.C.P.JAMES TABORN, M.D., GILES G. BOLE, M.D., F.A.C.P., GEORGE R. THOMPSON, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-648 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChildhood dermatomyositis is an inflammatory myopathy associated with dermal and constitutional symptoms (1). We have recently seen at the University of Michigan Medical Center two patients with childhood dermatomyositis and inactive muscle disease but persistently active calcinosis universalis. Both were febrile. After studies to exclude infection or other causes of fever, these patients were treated with low doses of colchicine. Although colchicine had no effect on the size of the calcium deposits, the local and systemic inflammatory signs quickly subsided.In 1958 a 14-year old girl presented with dermatomyositis. Large doses of hydrocortisone gradually suppressed her disease. In 1961 soft...References1. SULLIVANCASSIDYPETTY DJR: Dermatomyositis in the pediatric patient. Arthritis Rheum 20(suppl):327-331, 1977 MedlineGoogle Scholar2. RODNAN G: Progressive systemic sclerosis, in Arthritis and Allied Conditions: A Textbook of Rheumatology, 8th ed., edited by HOLLANDER JL, MCCARTY DJ JR. Philadelphia, Lea and Febiger, 1972, p. 994 Google Scholar3. SCHUMACHERSOMLYOTSEMAURER HARK: Arthritis associated with apatite crystals. Ann Intern Med 87:411-416, 1977 LinkGoogle Scholar4. MOSKOWITZVERTESSCHWARTZMARSHALLFRIEDMAN RVAGB: Crystal-induced inflammation associated with chronic renal failure treated with periodic hemodialysis. Am J Med 47:450-460, 1969 CrossrefMedlineGoogle Scholar5. THOMPSONTINGRIGGSFENNDENNING GYGMR: Calcification resembling gout. JAMA 203:122-130, 1968 CrossrefGoogle Scholar6. MCCARTYGATTER DR: Recurrent acute inflammation associated with focal apatite crystal deposition. Arthritis Rheum 9:804-819, 1966 CrossrefMedlineGoogle Scholar7. DENKOWHITEHOUSE CM: Experimental inflammation induced by naturally occurring microcrystalline calcium salts. J Rheumatol 3:54-62, 1976 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES TABORN, M.D.; GILES G. BOLE, M.D., F.A.C.P.; GEORGE R. 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