Isotretinoin in Metastatic Thyroid Cancer
Authors: Anne R. Borner
Journal: Annals of Internal Medicine (1997)

Letters1 August 1997Isotretinoin in Metastatic Thyroid CancerAnne R. Borner, MD, Dietmar Simon, MD, and Hans W. Muller-Gartner, MDAnne R. Borner, MDUniversity Hospital Dusseldorf; Dusseldorf, GermanyInstitute of Medicine Julich, GermanySearch for more papers by this author, Dietmar Simon, MDUniversity Hospital Dusseldorf; Dusseldorf, GermanyInstitute of Medicine Julich, GermanySearch for more papers by this author, and Hans W. Muller-Gartner, MDUniversity Hospital Dusseldorf; Dusseldorf, GermanyInstitute of Medicine Julich, GermanySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-3-199708010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although excellent results with 13-cis-retinoic acid (isotretinoin) have been reported in acute promyelocytic leukemia [1], the role of isotretinoin has not been fully established in the treatment of other malignancies. Oxyphilic follicular thyroid cancer is associated with a poor prognosis compared with other differentiated thyroid tumors [2]. No cure is known for metastatic disease. Spontaneous tumor regression in differentiated thyroid cancer is extremely rare. Influences on iodine metabolism, induction of 5′ deiodinase, and decreased proliferation in follicular thyroid cancer cells have been observed [3-5].In May 1993, a 72-year-old man presented with an oxyphilic follicular thyroid cancer ...References1. Degos L. Retinoic acid in promyelocytic leukemia. A model for differentiation therapy. Curr Opin Oncol. 1992; 4:42-52. Google Scholar2. Muller-Gartner HW, Brzac HT, Rehpenning W. Prognostic indices for tumor relapse and tumor mortality in follicular thyroid carcinoma. Cancer. 1991; 67:1903-11. Google Scholar3. Arai M, Tsushima T, Isozaki O, Shizume K, Emoto N, Demura H, et al. Effects of retinoids on iodine metabolism, thyroid peroxidase gene expression, and deoxyribonucleic acid synthesis in porcine thyroid cells in culture. Endocrinology. 1991; 129:2827-33. Google Scholar4. Schreck R, Schnieders F, Schmutzler C, Koehrle J. Retinoids stimulate type I iodothyronine 5′deiodinase activity in human follicular thyroid carcinoma cell lines. J Clin Endocrinol Metab. 1994; 79:791-8. Google Scholar5. Van Herle AJ, Agatep ML, Padua III DN, Totanes TL, Canlapan DV, Van Herle HM, et al. Effects of 13 cis-retinoic acid on growth and differentiation of human follicular carcinoma cells (UCLA RO 82 W-1) in vitro. J Clin Endocrinol Metab. 1990; 71:755-63. Google Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital Dusseldorf; Dusseldorf, GermanyInstitute of Medicine Julich, Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited By13-cis-retinoic acid re-differentiation therapy and recombinant human thyrotropin-aided radioiodine treatment of non-Functional metastatic thyroid cancer: a single-center, 53-patient phase 2 studyManagement of the patient with progressive radioiodine non-responsive diseaseAdvanced Stage Thyroid Cancer — Treatment with IsotretinoinChemotherapy and Biological Therapy of Thyroid Cancer 1 August 1997Volume 127, Issue 3Page: 246KeywordsCancer treatmentDyspneaLung and intrathoracic tumorsLungsLymph nodesThyroidThyroid carcinomaThyroidectomyThyroxineTomography Issue Published: 1 August 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...