tbuckley/cabot-search huggingface dataset:
A transforming growth factor beta 2 (TGF-beta 2)-like immunosuppressive factor in amniotic fluid and localization of TGF-beta 2 mRNA in the pregnant uterus.
Authors: D J Altman, S L Schneider, D A Thompson, H L Cheng, T B Tomasi
Journal: The Journal of Experimental Medicine (1990)

This report describes a murine amniotic fluid (MAF) immunosuppressive factor that has properties similar to transforming growth factor beta (TGF-beta). The MAF factor exhibits TGF-beta-like activity in stimulating soft agar colony formation by AKR-2B cells and inhibiting thymidine uptake by Mv1Lu cells. We demonstrate that both the immunosuppressive and TGF-beta-like activities of the MAF factor are completely neutralized by anti-TGF-beta 2-specific antibodies and not by anti-TGF-beta 1-specific antisera. The immunosuppressive factor in MAF is novel in that it appears to be identical or very closely related to TGF-beta 2 and is active in its native state. This active and anti-TGF-beta 2-neutralizable factor chromatographs at approximately 70 kD on Sephadex at neutral pH and appears to be able to complex with alpha-fetoprotein in native amniotic fluid. Chromatography of native MAF under acidic conditions demonstrates a lower molecular mass protein that chromatographs on BioGel in the same position as the mature 25-kD TGF-beta. This protein has the biological properties of TGF-beta and is immunosuppressive. Both of these activities are neutralizable with anti-TGF-beta 2 but not with anti-TGF-beta 1 or other antisera. By Northern analysis, we find high levels of TGF-beta 2 mRNA (with little or no TGF-beta 1) in the pregnant uterus that peak around day 15 of gestation and then fall rapidly by day 19 as birth approaches. The TGF-beta 2-like factor could possibly play a role in maternal immunity, in the retention of the fetal allograft, as well as in regulating fetal and neonatal immunological competence.
Evolution of vectorcardiographic QRS changes during myocardial infarction in dogs and their relation to infarct size
Authors: P. GROTTUM, B. MOHR, J. K KJEKSHUS
Journal: Cardiovascular Research (1986)

The ability of vectorcardiographic QRS changes to quantify myocardial ischaemia and necrosis in dogs was studied. Myocardial infarction was produced in 21 anaesthetised dogs by inflating a balloon inserted into the right, left anterior descending, or left circumflex coronary artery. A Frank vectorcardiogram was recorded before and every 15–30 minutes for 10 hours after the occlusion. ST vector magnitude (ST-VM), QRS summation vectors, and QRS integral differences (QRS-VD) between the preocclusion recording and subsequent recordings were computed. Twenty four hours after occlusion two vectorcardiograms were obtained, the hearts removed, and the infarcts cut out and weighed. Four dogs were excluded from the study because of persistent arrhythmias, major conduction defects, or sudden death. In the remaining 17 dogs the QRS summation vectors rotated maximally towards the site of infarction 7 minutes after occlusion corresponding to a median minimum QRS-VD of −19 (range −2 to −29) μVs. This coincided with the maximum ST-VM, median 0.43 (range 0.12 – 0.68) mV. The QRS summation vectors subsequently rotated away from the infarct producing a median maximum QRS-VD of 20 (range 6–28) μVs. The maximum QRS-VD correlated significantly with the percentage of infarcted myocardium (r=0.82). The correlation between the early minimum QRS-VD and the maximum ST-VM was r=0.83. The QRS-VD was recomputed with a reference taken 2 or 4 hours after occlusion. The relation between maximum QRS-VD and infarct percentage was not significantly changed with the reference at 2 hours, but with the reference at 4 hours the ability to predict infarct size was lost. With a common reference representing the median of the preocclusion recordings the correlation between maximum QRS-VD and infarct percentage was r=0.60. Examination of various QRS time integrals showed that the integral from QRS beginning to QRS end produced the highest correlations with infarct percentage. These results indicate that with a proper preinfarction reference serial assessment of QRS integral differences in the Frank vectorcardiogram can be used to quantify both the ischaemic area and the final size of a myocardial infarct and to follow the progression of the evolving infarction. This technique can therefore represent a valuable adjunct in monitoring the infarction process and in studying infarct limiting treatment in the coronary care unit.
The Catheter Pacemaker in Complete Heart Block
Authors: Edward W. Bixby
Journal: JAMA (1965)

ABSTRACT To the Editor:— In connection with A. J. Gordon's Catheter Pacing in Complete Heart Block (193:1091, 1965), we have had recent experience from approximately 15 patients with Stokes-Adams syndrome. We have found catheter pacing through the right ventricle a very successful intermediate step between external pacing and an implant pacemaker for patients requiring at least 24-hour prophylactic adjunct pacing.We have had no really serious complications, although minor adjustment frequently seems required. We have found a unipolar pacemaker much the more desirable because it avoids the necessity for a ground wire suture to the skin and associated irritating crosscurrents. We have been successful in placing the catheter blind by using a small monitor-pacemaker that can record the natural heart voltage from a catheter implant. When the monitor can receive a signal, we have been able to pace artificially.This method permits us to place the catheter into an internal
Treatment of Lipodystrophy with Troglitazone
Authors: Jose S. Cheng
Journal: Annals of Internal Medicine (2001)

Letters19 June 2001Treatment of Lipodystrophy with TroglitazoneJose S. Cheng, MDJose S. Cheng, MDBaylor College of Medicine; Houston, TX 77005 (Cheng)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-12-200106190-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with fascination the article by Arioglu and colleagues regarding the treatment of lipodystrophy syndromes (1). However, I am puzzled: Body fat, after 6 months of troglitazone therapy, increased by 2.4 percentage points, most significantly at the subcutaneous region. The respiratory quotient decreased by 0.12, which was also highly significant. These data indicate that lipogenesis and oxidation of lipids were both favored, and yet the authors assured us that the patients' diets were unaltered. Where did the additional lipids come from? Troglitazone treatment resulted in significant increases in subcutaneous fat but insignificant decreases in visceral abdominal ...References1. Arioglu E, Duncan-Morin J, Sebring N, Rother K, Gottlieb N, Lieberman J, et al . Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Ann Intern Med. 2000;133:263-74. [PMID: 10929166] LinkGoogle Scholar2. Hadigan C, Corcoran C, Stanley T, Piecuch S, Klibanski A, Grinspoon S. Fasting hyperinsulinemia in human immunodeficiency virus-infected men: relationship to body composition, gonadal function, and protease inhibitor use. J Clin Endocrinol Metab. 2000;85:35-41. [PMID: 10634360] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine; Houston, TX 77005 (Cheng) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEfficacy and Safety of Troglitazone in the Treatment of Lipodystrophy Syndromes Elif Arioglu , Jennifer Duncan-Morin , Nancy Sebring , Kristina I. Rother , Nicole Gottlieb , Jay Lieberman , David Herion , David E. Kleiner , James Reynolds , Ahalya Premkumar , Anne E. Sumner , Jay Hoofnagle , Marc L. Reitman , and Simeon I. Taylor Treatment of Lipodystrophy with Troglitazone Elif Arioglu and Simeon I. Taylor Metrics 19 June 2001Volume 134, Issue 12Page: 1153KeywordsDietFatsInsulinInsulin resistanceLipidsLipodystrophyLipogenesisNucleosidesProtease inhibitorsReverse transcriptase inhibitors ePublished: 19 June 2001 Issue Published: 19 June 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Isolation of cells that retain differentiated functions in vitro: properties of clonally isolated type II alveolar pneymonocytes.
Authors: W H Douglas, P M Farrell
Journal: Environmental Health Perspectives (1976)

We have isolated byclonal culture techniques a diploid cell strain (L-2) from adult rat lung. These cells appear to retain differentiated functions that are present in type II alveolar epithelial cells of intact lung. The L-2 cells are diploid, epithelial cells, they contain osmiophilic lamellar bodies in their cytoplasm and they synthesize lecithin by the same de novo pathways as whole lung.
Inflammatory bowel disease in Asians.
Authors: P S Phull, M R Jacyna
Journal: Gut (1993)

Letters the appreciable differences seen in the results.The studies of Lauritsen et al, with faecal dialysates reflect only the intraluminal concen- trations but provide no information about the intramucosal concentrations.The information that results from both types of studies, how- ever, can be complementary.Finally, we totally agree that the very low mucosal concentrations of 5-ASA after Salazopyrin supports the hypothesis that Salazopyrin has pharmocological properties that are different from those of 5-ASA and contribute to its therapeutic efficacy.
Platelets of the Wistar Furth rat have reduced levels of alpha-granule proteins. An animal model resembling gray platelet syndrome.
Authors: C W Jackson, N K Hutson, S A Steward, N Saito, E M Cramer
Journal: Journal of Clinical Investigation (1991)

Rats of the Wistar Furth (WF) strain have hereditary macrothrombocytopenia (large mean platelet volume [MPV] with increased platelet size heterogeneity and reduced platelet count). Ultrastructural studies suggest that this anomaly results from erratic subdivision of megakaryocyte cytoplasm into platelets. In this study, we have examined protein profiles of platelets of WF rats for biochemical abnormalities associated with this anomaly. Marked decreases in protein bands with an Mr of 185, 57, 53, 16, 13, and 8 kd were observed in one-dimensional reduced SDS-PAGE gels in WF platelets compared with platelets of Wistar, Long Evans, and Sprague-Dawley rats. These proteins were released into the supernatant when washed platelets were treated with thrombin suggesting that they were alpha-granule proteins. These abnormalities were not present in offspring of crosses between Wistar Furth and Wistar rats; however, they were present in platelets of offspring with large MPV derived from backcrosses of (WF X Wistar) F1 males to WF females, but not in backcross offspring with normal platelet size. Immunoblotting confirmed decreased levels of thrombospondin, fibrinogen, and platelet factor 4 in WF platelets. Electron microscopic examination revealed that platelet alpha granules were usually smaller in Wistar Furth than in Wistar rats. In addition, immunogold electron microscopy demonstrated that the surface connected canalicular system of the large Wistar Furth platelets, contained dense material composed of alpha-granule proteins, not present in Wistar platelets. From these results, we conclude that the Wistar Furth rat platelet phenotype of large mean platelet volume and decreased levels of alpha-granule proteins represents an animal model resembling gray platelet syndrome. The autosomal recessive pattern of inheritance of the large MPV phenotype and platelet alpha-granule protein deficiencies suggests that a component common to both formation of platelet alpha granules, and subdivision of megakaryocyte cytoplasm into platelets, is quantitatively or qualitatively abnormal in Wistar Furth rat megakaryocytes and platelets.
Factitious Subcutaneous Emphysema
Authors: M. ERIC GERSHWIN
Journal: Annals of Internal Medicine (1971)

A 28-year-old housewife was hospitalized on three occasions for subcutaneous emphysema of unknown origin. Its cause was finally determined as self-induced; during one hospitalization the patient also produced a factitious fever. This cause of subcutaneous emphysema has apparently not been recognized hitherto.
Effects on Coagulation and Fibrinolysis With Reduced Versus Full Systemic Heparinization and Heparin-Coated Cardiopulmonary Bypass
Authors: Eivind Øvrum, Frank Brosstad, Einfrid Åm Holen, Geir Tangen, Michel Abdelnoor
Journal: Circulation (1995)

Background Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in part unknown. Methods and Results Indications of thrombin generation, platelet activation, and fibrinolytic activity were investigated in patients undergoing coronary artery bypass surgery. Two groups were perfused with cardiopulmonary bypass (CPB) circuits completely coated with surface-bound heparin: one group with low systemic heparin dose (activated clotting time [ACT] &gt;250 seconds; n=17) and a second group having a full heparin dose (ACT &gt;480 seconds; n=18). A third control group was perfused with ordinary uncoated circuits and full heparin dose (n=17). The plasma level of thrombin-antithrombin complex and prothrombin fragment 1.2 increased in all groups during bypass, and somewhat more in both the heparin-coated groups toward the end of CPB, compared with the control group ( P &lt;.01). However, the increase during CPB was minimal compared with the major elevation observed 2 hours after surgery in all groups. Platelet release of β-thromboglobulin increased in all groups ( P &lt;.01) during CPB and significantly more in the high-dose group compared with the other two groups ( P =.03). Fibrinolytic activities were similar in all groups, and there were no indications of major consumption of coagulation factors. Conclusions Reduced systemic heparinization (ACT &gt;250 seconds) in patients having extracorporeal circulation with completely heparin-coated circuits did not lead to increased thrombogenicity. Thrombin formation remained within low ranges during CPB compared with patients receiving a full heparin dose and with the major elevations observed after surgery.
Liver iron overload in patients with chronic active hepatitis C. Prevalence, role of the hemochromatosis gene and relation with hepatic histological lesions
Authors: C. Hézode, C. Cazeneuve, O. Coué, I. Lonjon, F. Roudot-Thoraval, A. Bastie, C. Duvoux, JM. Pawlotsky, E.S. Zafrani, E. Girodon, D. Dhumeaux
Journal: Journal of Hepatology (1998)
REPORT OF THE STANDING COMMITTEE ON METEOROLOGICAL CONDITIONS AND THEIR RELATIONS TO THE PREVALENCE OF ACUTE DISEASES.
Authors: N. S. DAVIS
Journal: JAMA (1884)

[Presented to the American Medical Association in session at Cleveland, Ohio, June 7, 1883.] [Continued from No. 4, Vol. II.] The following tables present in a condensed form the amount of free and albuminoid ammonia in the atmosphere in the city of Chicago, at a station where the population is moderately dense, of good quality, with fairly good sewerage and water supply, as determind by Prof. Long for each day of the twelve months ending August 31, 1883: These tabulated details giving the results of most careful daily examination of the atmosphere during an entire year in the same locality, and by uniform processes, develope several facts of value. First, they show that both free and albuminoid ammonia are constant elements of the atmosphere, at least in cities or densely populated localities, their presence in quantity capable of measurement having been found every day in the year. Second, that the
Cardiac Imaging Impaired by a Silicone Breast Implant
Authors: Trip J. Meine, Manesh R. Patel, John Heitner, Terry A. Fortin, Robert A. Pagnanelli, Thomas R. Gehrig, Raymond Kim, Salvador Borges-Neto
Journal: Clinical Nuclear Medicine (2005)

The authors report a case of a left-sided silicone breast implant interfering with nuclear imaging of the myocardium. Cardiac SPECT imaging of a woman documented widespread infarct in the anterolateral, inferior, and posterolateral walls, as well as mixed ischemia/infarct in the anterior wall. Subsequent cardiac MRI revealed just anterolateral and inferolateral infarct. The anterior wall was completely viable. Also apparent on the MR images was a left breast implant overlying the anterior myocardial wall. This case of a left-sided silicone breast implant interfering with nuclear imaging of the myocardium highlights the importance of understanding the potential interference from silicone breast implants.
Treatment of Chloroquine-Resistant Malaria During Pregnancy
Authors: Elliott K. Main
Journal: JAMA (1983)

A pregnant 36-year-old Vietnamese refugee with chloroquine-resistant<i>Plasmodium falciparum</i>infection was treated with pyrimethamine and a sulfonamide. This treatment produced rapid clearance of the patient's parasitemia and was associated with a resumption of normal fetal and uterine growth. Because the other drugs effective against chloroquine-resistant<i>P falciparum</i>may produce uterine stimulation (quinine sulfate) or damage the fetal skeleton (tetracyclines), the pyrimethamine-sulfonamide combination (with folinic acid supplementation) may be the best available choice for the treatment and prophylaxis of chloroquine-resistant<i>P falciparum</i>infection in pregnancy, despite its theoretical risk of teratogenicity. (<i>JAMA</i>1983;249:3207-3209)
Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma
Authors: Ai-Wu Ke, Guo-Ming Shi, Jian Zhou, Fei-Zhen Wu, Zhen-Bin Ding, Mei-Yu Hu, Yang Xu, Zheng-Ji Song, Zhi-Jun Wang, Jin-Cai Wu, Dou-Sheng Bai, Jia-chu Li, Kang-Da Liu, Jia Fan
Journal: Hepatology (2008)

It has been reported that tetraspanin CD151 acts as a promoter of metastasis in several tumors and plays an important role in c-Met/hepatocyte growth factor signaling. However, the role of CD151 alone and coexpression of CD151/c-Met in hepatocellular carcinoma (HCC) remains unclear. We found that expression of CD151 was positively related to metastatic potential of HCC cell lines, and modified cells with CD151(high) showed higher secretion of matrix metalloproteinase 9 and aggressiveness in vitro and higher metastatic ability in vivo. Furthermore, HCC patients with vascular invasion, large tumors, multiple tumors, high tumor-node-metastasis stage, and undifferentiated tumor were prone to have higher CD151 expression. The postoperative 3-, 5-, and 7-year overall survival (OS) of patients in HCCs with CD151(high) were significantly lower than those in the CD151(low) group, and correspondingly cumulative recurrence rates in HCCs with CD151(high) were significantly higher than those in the CD151(low) group. Both CD151 and c-Met were remarkably overexpressed in HCCs, compared with adjacent nontumorous and normal liver tissues. Pearson correlation analysis showed a slight correlation between CD151 and c-Met in HCCs. Importantly, the 5- and 7-year OS rates in CD151(high)/c-Met(high) patients were 50.5% and 37.8%, respectively, significantly lower than those of CD151(low)/c-Met(low) patients (63.9% and 54.6%, respectively). Five- and 7-year cumulative recurrence rates in CD151(high)/c-Met(high) patients were 53.3% and 71.9%, respectively, markedly higher than those of CD151(low)/c-Met(low) patients (39.0% and 52.5%, respectively). Multivariate analysis revealed that CD151 and combination of CD151/c-Met were independent prognostic indicators for OS and cumulative recurrence.CD151 is positively associated with invasiveness of HCC, and CD151 or combination of CD151/c-Met is a novel marker in predicting the prognosis of HCC and a potential therapeutic target.
Feigned Amnesia as a Defense Reaction*
Authors: George E. Price, William B. Terhune
Journal: JAMA (2019)

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Blair tackled on heart deaths
Authors: Roger Dobson
Journal: BMJ (2000)

Twenty patients waiting for heart surgery in Bristol have died within the past six months, the British prime minister, Tony Blair, was told in a face to face debate with doctors, nurses, and NHS managers.

In a wide ranging debate on the NHS held at St Thomas's Hospital, London, Mr Blair was grilled about waiting lists, clinical priorities, staff shortages, and the use of resources. Peter Wilde, director of cardiothoracic services for the United Bristol Healthcare NHS Trust, told the prime minister about big regional differences …
Cerebrospinal Fluid Glycoproteins in Schizophrenia
Authors: ROBERT J. CAMPBELL, SAMUEL BOGOCH, MICHAEL J. SCOLARO, PETER C. BELVAL
Journal: American Journal of Psychiatry (1967)

A double-blind clinical and chemical study of 131 hospitalized psychotic patients, totally removed geographically from the center at which chemical analyses were performed, demonstrated an inverse relationship between the quantity of cerebrospinal fluid glycoprotein neuraminic acid and the severity of schizophrenia, with a high concordance between chemical levels, changes in clinical condition, and family history. In addition, changes in cerebrospinal fluid glycoprotein hexose were related inversely to clinical estimates of depression.