tbuckley/cabot-search huggingface dataset:
Morphologic, Secretory, and Cell Proliferation Characteristics of Atrophic Gastric Mucosa.
Authors: Sidney J. Winawer
Journal: Annals of Internal Medicine (1967)

s1 May 1967Morphologic, Secretory, and Cell Proliferation Characteristics of Atrophic Gastric Mucosa.Sidney J. Winawer, M.D., F.A.C.P.Sidney J. Winawer, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1033_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCertain diseases of the stomach such as ulcer and carcinoma occur with greater frequency in mucosa containing chronic inflammatory changes. These abnormalities, observed by others and by us in a large number of patients, have been classified as atrophic gastritis when there is cellular infiltrate into the lamina propria accompanied by decreased or absent parietal and chief cells. The atrophic mucosa may also contain degenerating epithelial and glandular cells, increased numbers of lymphoid follicles, and, also, intestinal cells. The degree of intestinalization parallels the severity of the atrophic process and is characterized by the presence of intestinal columnar, goblet, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1033-1033KeywordsCell proliferationEpithelial cellsGastric mucosaGastric ulcersGastritisLymphocytesMucous membranesStomach Issue Published: 1 May 1967 PDF DownloadLoading ...
Doctors issue warning over misuse of slang
Authors: R. Dobson
Journal: BMJ (2003)

Doctors have been advised to cut back on the use of slang, especially in medical notes.

The authors of what is described as the first list of slang terms currently in use in British medical establishments say that use of derogatory slang and acronyms may lead to patients being devalued.

“Although acknowledging that slang is likely to continue to be used, it should be kept to a minimum. With so much of the language being derogatory, it should be avoided in medical notes and only those terms used that are properly defined and unambiguous in nature,” …
P80 ANGIOGENESIS POLYMORPHISMS PROFILE IN THE PREDICTION OF CLINICAL OUTCOME OF ADVANCED HCC PATIENTS RECEIVING SORAFENIB: COMBINED ANALYSIS OF VEGF AND HIF-1α. THE ALICE-2 STUDY
Authors: L. Faloppi, M. Scartozzi, M. D'Anzeo, M. Bianconi, G. Svegliati Baroni, N. Silvestris, A. Casadei Gardini, G. Masi, R. Giampieri, M. Del Prete, S. De Minicis, A. Mandolesi, A. Benedetti, S. Cascinu
Journal: Journal of Hepatology (2014)
The Addition of an Air/Water Button to a Flexible Bronchoscope (Provided with a Suction Button) for Use as a Slim Operative Panendoscope
Authors: D. Oselladore, R. Rossoni
Journal: Endoscopy (1988)

Thin-caliber (4.9 and 6.3 mm) flexible bronchoscopes already provided with a suction button have been modified by adding an air/water button for the control of air insufflation and water irrigation; the channel used is the biopsy-suction one. With the aid of this instrument, several pathologies can be studied and treated, under adverse conditions such as esophageal or recto-sigmoidal stenosis, hematuria in polytraumatic patients, residual stones in patients carrying a T-tube, acute respiratory obstructions, etc.
Changes in Myocardial Electrical Impedance Induced by Coronary Artery Occlusion in Pigs With and Without Preconditioning
Authors: Juan Cinca, Mark Warren, Ana Carreño, Màrius Tresànchez, Lluís Armadans, Pilar Gómez, J. Soler-Soler
Journal: Circulation (1997)

Myocardial ischemia increases tissue electrical resistivity leading to cell-to-cell uncoupling, and this effect is delayed by ischemic preconditioning in isolated myocardium. Alterations in myocardial resistivity elicited by ischemia in vivo may influence arrhythmogenesis and local ST-segment changes, but this is not well known.Myocardial impedance (resistivity [omega x cm] and phase angle [degrees]), epicardial ST segment, and ventricular arrhythmias were analyzed during 4 hours of coronary artery occlusion in 11 anesthetized open-chest pigs; these were compared with 13 other pigs submitted to a similar coronary occlusion preceded by ischemic preconditioning. Myocardial resistivity rose slowly during the first 34+/-7 minutes of occlusion (237+/-41 to 359+/-59 omega x cm), increased rapidly to 488+/-100 omega x cm at 60 minutes, and reached a plateau value (718+/-266 omega x cm, ANOVA; P<.01) at 150+/-69 minutes. By contrast, phase-angle changes began after 17 minutes of ischemia (-3.0+/-1.6 degrees to -4.2+/-1.2 degrees at 29+/-8 minutes) and evolved faster thereafter (-12.5+/-5.3 degrees at 144+/-56 minutes). Marked changes in myocardial impedance were observed during the reversion of ST-segment elevation that occurred 1 to 4 hours after occlusion, but impedance changes were less apparent during the early ST-segment recovery seen at 15 to 35 minutes of ischemia. The second arrhythmia peak (30+/-5 minutes) coincided with the fast change in tissue impedance, and both were delayed (P<.05) by ischemic preconditioning.A rapid impairment of myocardial impedance occurs after 30 minutes of coronary occlusion, and its onset is better defined by shift in phase angle than by rise in tissue resistivity. Phase 1b arrhythmias are associated with marked impedance changes, and both are delayed by preconditioning. Reversion of ST-segment elevation is partially associated with impairment of myocardial impedance, but other factors play a role as well.
Introduction
Authors: Kevin B. Weiss
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Mechanical ventilation using a modified endotracheal tube, allowing bypass and washout of the endotracheal dead space (McETV), was compared with conventional controlled mechanical ventilation (CMV) in healthy and in surfactant-depleted rabbits. In healthy animals, shifting from CMV to McETV led to an increase in PaO2 (89 +/- 16 versus 104 +/- 13 mm Hg; p < 0.05) and a decrease in PaCO2 (41.5 +/- 3 versus 30 +/- 3 mm Hg; p < 0.05). As a result of reducing the peak inspiratory pressure (PIP) from 21 +/- 2 to 12 +/- 2 cm H2O (p < 0.05), it was possible in McETV mode to maintain comparable ventilation to that achieved by CMV. In surfactant-depleted animals, compared with CMV, McETV produced a rise in PaO2 without change in thoracic volume (from 100 +/- 40 to 150 +/- 60 mm Hg, p < 0.05) and a fall in PaCO2 (from 46 +/- 5 to 37 +/- 4 mm Hg, p < 0.05). After 4 h of ventilation, the surfactant-depleted animals from the CMV group developed thoracic overdistension quicker (at hour 1, p < 0.05) and, consequently, more animals died from pneumothorax compared with the McETV group (five versus two). We concluded that McETV ensured adequate gas exchanges with lower insufflation pressures and could diminish positive pressure ventilation-induced injury.
Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates.
Authors: K Welte, M A Bonilla, A P Gillio, T C Boone, G K Potter, J L Gabrilove, M A Moore, R J O'Reilly, L M Souza
Journal: The Journal of Experimental Medicine (1987)

We examined the in vivo effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in primates (cynomolgus monkeys) treated with subcutaneous doses of rhG-CSF for 14-28 d. A dose-dependent increase in the peripheral white blood cells (WBC) was seen, reaching a plateau after 1 wk of rhG-CSF treatment. The elevation of WBC was due to an increase in the absolute neutrophil count. These results demonstrate that rhG-CSF is a potent granulopoietic growth and differentiation factor in vivo. In cyclophosphamide (CY)-induced myelosuppression, rhG-CSF was able to shorten the time period of WBC recovery in two treated monkeys to 1 wk, as compared to more than 4 wk for the control monkey. Its ability to significantly shorten the period of chemotherapy-induced bone marrow hypoplasia may allow clinicians to increase the frequency or dosage of chemotherapeutic agents. In addition, the increase in absolute numbers of functionally active neutrophils may have a profound effect in the rate and severity of neutropenia-related sepsis. Furthermore, the activities reported here indicate a potential role for rhG-CSF in the treatment of patients with myelodysplastic syndrome, congenital agranulocytosis, radiation-induced myelosuppression, and bone marrow transplantation.
A Comparison of the Cerebral Hemodynamic Response to Aramine and Norepinephrine in the Normotensive and the Hypotensive Subject
Authors: JOHN H. MOYER, GEORGE MORRIS, HARVEY SNYDER, C. POLK SMITH
Journal: Circulation (1954)

Previous observations have demonstrated a depression in cerebral blood flow during controlled hypotension with ganglionic blocking agents. Cerebral blood flow is also decreased when normotensive individuals are made hypertensive by the administration of vasopressor agents. The opposite response is observed when hypotensive individuals are made normotensive by the administration of these same agents, in which circumstance cerebral blood flow is increased.
The Lurking Sperm: Vasectomy Failures
Authors: Philip M. Alderman
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I would like to reply to the editorial in which Dr Schmidt<sup>1</sup>asserts that his method of performing vasectomies has been failure free in 5000 cases. My article<sup>2</sup>in the same issue— entitled "The Lurking Sperm"—acknowledged this remarkable record, but also noted the lack of confirmation in the medical literature that his results can be achieved by others. I believe that colleagues who perform vasectomies may be more interested in a reproducible technique that offers 98% to 99% successful results (depending on definitions) than in a different method that provides 100% success—but only in the hands of one individual. As for patients, it is apparent that not all of the 400 000 or so men who have vasectomies annually in the United States<sup>3</sup>can take advantage of such unique skills. Dr Schmidt mentions that I "cautiously and bravely" inform my technical failures (men with
COMPARISON OF CLINICAL OUTCOMES BETWEEN OCTOGENARIAN AND NON-OCTOGENARIAN ACUTE MYOCARDIAL INFARCTION PATIENTS
Authors: Futoshi Yamanaka, Myung Ho Jeong, Youngkeun Ahn, Shung Chull Chae, Seung Ho Hur, Taek Jong Hong, Young Jo Kim, In Whan Seong, Jei Keon Chae, Jay Young Rhew, In Ho Chae, Myeong Chan Cho, Jang Ho Bae, Seung Woon Rha, Chong Jin Kim, Donghoon Choi, Yang Soo Jang, Junghan Yoon, Wook Sung Chung, Jeong Gwan Cho, Ki Bae Seung
Journal: Journal of the American College of Cardiology (2012)
Impact of heart valve decellularization on 3-D ultrastructure, immunogenicity and thrombogenicity
Authors: Jianye Zhou, Olaf Fritze, Martina Schleicher, Hans-Peter Wendel, Katja Schenke-Layland, Csaba Harasztosi, Shengshou Hu, Ulrich A. Stock
Journal: Biomaterials (2010)
Dilated Cardiomyopathies of the Adult
Authors: Robert Arnold Johnson, Igor Palacios
Journal: New England Journal of Medicine (1982)

Cardiomyopathies are diseases of the myocardium. We use the term "cardiomyopathy" here to refer to a disorder that directly affects one or both cardiac ventricles in a diffuse or multifocal fashion, and that produces heart failure at least in some patients. This definition embraces both the linguistic roots of the word and the clinical context in which the concept of cardiomyopathy is most useful — namely, in specifying those instances in which heart failure results from a myocardial disease rather than from an extrinsic disorder, such as valvular disease, a circulatory shunt, pericardial disease, uncontrolled hypertension, . . .
Allergy to Mould Spores in Britain
Authors: H. A. Hyde, M. Richards, D. A. Williams
Journal: BMJ (1956)

Mortality rates for respiratory tuberculosis for both sexes over 65 show a rise from 58 in 1938 to a peak of 81 in 1951 for men, but a steady decline from 22 to 13 for women.All figures show a worsening for men over 65 com- pared with women in the last 17 years, so that by 1954 male notification and death rates were about five times the female rates.Even if rising notification rates in old men are due to increased case-finding there is evidence that a large number of these cases exist to be found, and it is sug- gested that the problem of reactivation in old men merits further epidemiological study.A series of 35 cases is presented of men fit up to age 65 who subsequently developed active disease, probably usually due to reactivation of old lesions.Cases are classified according to mode of onset, 46% showing no prominent chest symptoms, often in spite of extensive active disease.Well-known social and medical predisposing factors were found in only about half the cases.Some suggestions are made to promote earlier recognition of these cases in view of their obvious danger to the community.I acknowledge with thanks the help received from Dr. S. A. C.
Brief Communication: Physician Interest in Volunteer Service during Retirement
Authors: Philip D. Sloane, Lauren W. Cohen, Thomas R. Konrad, Christianna S. Williams, John G. Schumacher, Sheryl Zimmerman
Journal: Annals of Internal Medicine (2008)

Background: Baby boomers approaching retirement will include unprecedented numbers of physicians, many of whom want to remain productive. Objective: To determine interest in health care–related volunteering during retirement among physicians trained to provide general medical care to adults. Design: Cross-sectional mailed survey conducted May through July 2006. Setting: North Carolina. Participants: 910 physicians, 55 years of age or older, whose primary specialty involved direct, nonsurgical care of adults. Measurements: Current volunteerism and future interest in selected activities. Results: Of the respondents, 89.8% were male and 87.4% were white; 57.4% worked full-time, 21.7% worked part-time, and 21.0% were retired. Of current retirees, 37.1% expressed interest in volunteering. Areas of greatest interest were medical teaching, working in free medical clinics, and international care. Strong incentives included staying mentally active (67.3%) or involved in medicine (61.2%) and contributing to society (60.5%). Substantial barriers included concerns about malpractice (61.5%) and paperwork or bureaucracy (46.0%). The majority of respondents (66.7%) felt that lack of payment would not influence volunteering. Limitations: The 59% overall response rate and exclusion of unlicensed retired physicians limit study generalizability. The data were provided by self-response and could not be independently validated. Conclusion: Retired physicians are a potential source of manpower that could contribute to provision of health care, particularly in medical teaching and clinical care of underserved persons.
Nordihydroguaiaretic Acid Inhibits an Activated Fibroblast Growth Factor Receptor 3 Mutant and Blocks Downstream Signaling in Multiple Myeloma Cells
Authors: April N. Meyer, Christopher W. McAndrew, Daniel J. Donoghue
Journal: Cancer Research (2008)

Abstract Activating mutations within fibroblast growth factor receptor 3 (FGFR3), a receptor tyrosine kinase, are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes, Thanatophoric Dysplasia (TD) type I and II. Several of these same FGFR3 mutations have also been identified somatically in human cancers, including multiple myeloma, bladder carcinoma, and cervical cancer. Based on reports that strongly activated mutants of FGFR3 such as the TDII (K650E) mutant signal preferentially from within the secretory pathway, the inhibitory properties of nordihydroguaiartic acid (NDGA), which blocks protein transport through the Golgi, were investigated. NDGA was able to inhibit FGFR3 autophosphorylation both in vitro and in vivo. In addition, signaling molecules downstream of FGFR3 activation such as signal transducers and activators of transcription (STAT)1, STAT3, and mitogen-activated protein kinase (MAPK) were inhibited by NDGA treatment. Using HEK293 cells expressing activated FGFR3-TDII, together with several multiple myeloma cell lines expressing activated forms of FGFR3, NDGA generally resulted in a decrease in MAPK activation by 1 hour, and resulted in increased apoptosis over 24 hours. The effects of NDGA on activated FGFR3 derivatives targeted either to the plasma membrane or the cytoplasm were also examined. These results suggest that inhibitory small molecules such as NDGA that target a specific subcellular compartment may be beneficial in the inhibition of activated receptors such as FGFR3 that signal from the same compartment. [Cancer Res 2008;68(18):7362–70]
Uncomplicated first myocardial infarction: Strategy for comprehensive prognostic studies
Authors: Jaume Candell-Riera, Gaietà Permanyer-Miralda, Joan Castell, Andreu Rius-Daví, Enric Domingo, Empar Álvarez-Auñón, Montserrat Olona, Josep Rosselló, Domènec Ortega, Francesc M. Domènech-Torné, Jordi Soler-Soler
Journal: Journal of the American College of Cardiology (1991)
An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart
Authors: Qi-Zhi Chen, Hikaru Ishii, George A. Thouas, Alexander R. Lyon, Jamie S. Wright, Jonny J. Blaker, Wojciech Chrzanowski, Aldo R. Boccaccini, Nadire N. Ali, Jonathan C. Knowles, Siân E. Harding
Journal: Biomaterials (2010)
Queue for drug registrations grows longer in China
Authors: J. Parry
Journal: BMJ (2015)

China’s Center for Drug Evaluation has reported a large rise in the backlog of drug registration applications, up by a third in 2014 compared with the previous year. Industry observers attribute this to severe understaffing at the agency, an increasing number of applications, and the requirement for clinical trials to be conducted in Chinese populations as a prerequisite for registration.

In its annual report the centre said that it had 18 597 applications awaiting approval at the end of 2014, which included new drug applications, renewals for drugs that must be completed every five years, and change applications (for different dosage, alternative route …
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
Authors: Karin R. Engelhardt, Sean McGhee, Sabine Winkler, Atfa Sassi, Cristina Woellner, Gabriela Lopez-Herrera, Andrew Chen, Hong Sook Kim, Maria Garcia Lloret, Ilka Schulze, Stephan Ehl, Jens Thiel, Dietmar Pfeifer, Hendrik Veelken, Tim Niehues, Kathrin Siepermann, Sebastian Weinspach, Ismail Reisli, Sevgi Keles, Ferah Genel, Necil Kutuculer, Yıldız Camcıoğlu, Ayper Somer, Elif Karakoc-Aydiner, Isil Barlan, Andrew Gennery, Ayse Metin, Aydan Degerliyurt, Maria C. Pietrogrande, Mehdi Yeganeh, Zeina Baz, Salem Al-Tamemi, Christoph Klein, Jennifer M. Puck, Steven M. Holland, Edward R.B. McCabe, Bodo Grimbacher, Talal A. Chatila
Journal: Journal of Allergy and Clinical Immunology (2009)
Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL)
Authors: Renato Bassan, Orietta Spinelli, Elena Oldani, Tamara Intermesoli, Manuela Tosi, Barbara Peruta, Giuseppe Rossi, Erika Borlenghi, Enrico M. Pogliani, Elisabetta Terruzzi, Pietro Fabris, Vincenzo Cassibba, Giorgio Lambertenghi-Deliliers, Agostino Cortelezzi, Alberto Bosi, Giacomo Gianfaldoni, Fabio Ciceri, Massimo Bernardi, Andrea Gallamini, Daniele Mattei, Eros Di Bona, Claudio Romani, Anna Maria Scattolin, Tiziano Barbui, Alessandro Rambaldi
Journal: Blood (2009)
Cardiac Calcification Causing Arrhythmia Detected by Technetium-99m MDP and SPECT
Authors: HAZEL B. BREITZ, PAUL S. SIROTTA, MICHAEL M. GRAHAM
Journal: Clinical Nuclear Medicine (1988)

SPECT was used to identify a focal accumulation of cardiac calcification using Tc-99m MDP in a patient with an arrhythmia and known metastatic calcification elsewhere.
Determinants of Adherence to Diabetes Medications: Findings From a Large Pharmacy Claims Database
Authors: M. Sue Kirkman, Megan T. Rowan-Martin, Rebecca Levin, Vivian A. Fonseca, Julie A. Schmittdiel, William H. Herman, Ronald E. Aubert
Journal: Diabetes Care (2015)

OBJECTIVE Adults with diabetes typically take multiple medications for hyperglycemia, diabetes-associated conditions, and other comorbidities. Medication adherence is associated with improved outcomes, including reduced health care costs, hospitalization, and mortality. We conducted a retrospective analysis of a large pharmacy claims database to examine patient, medication, and prescriber factors associated with adherence to antidiabetic medications. RESEARCH DESIGN AND METHODS We extracted data on a cohort of &amp;gt;200,000 patients who were treated for diabetes with noninsulin medications in the second half of 2010 and had continuous prescription benefits eligibility through 2011. Adherence was defined as a medication possession ratio ≥0.8. We used a modified adherence measure that accounted for switching therapies. Logistic regression analysis was performed to determine factors independently associated with adherence. RESULTS Sixty-nine percent of patients were adherent. Adherence was independently associated with older age, male sex, higher education, higher income, use of mail order versus retail pharmacies, primary care versus nonendocrinology specialist prescribers, higher daily total pill burden, and lower out-of-pocket costs. Patients who were new to diabetes therapy were significantly less likely to be adherent. CONCLUSIONS Several demographic, clinical, and potentially modifiable system-level factors were associated with adherence to antidiabetic medications. Patients typically perceived to be healthy (those who are younger, new to diabetes, and on few other medications) may be at risk for nonadherence. For all patients, efforts to reduce out-of-pocket costs and encourage use of mail order pharmacies may result in higher adherence.
A novel recurrent translocation t(11;14)(p11;q32) in splenic marginal zone B cell lymphoma
Authors: A Cuneo, A Bardi, I Wlodarska, D Selleslag, MG Roberti, R Bigoni, F Cavazzini, C De Angeli, E Tammiso, L del Senno, P Cavazzini, A Hagemeijer, G Castoldi
Journal: Leukemia (2001)