Renal Function in Donors and Recipients of Renal Allotransplantation
Authors: JAMES V. DONADIO
Journal: Annals of Internal Medicine (1967)

Article1 January 1967Renal Function in Donors and Recipients of Renal AllotransplantationRadioisotopic MeasurementsJAMES V. DONADIO JR., M.D., CHARLES D. FARMER, M.D., JAMES C. HUNT, M.D., F.A.C.P., W. NEWLON TAUXE, M.D., GEORGE A. HALLENBECK, M.D., ROY G. SHORTER, M.D.JAMES V. DONADIO JR., M.D.Search for more papers by this author, CHARLES D. FARMER, M.D.Search for more papers by this author, JAMES C. HUNT, M.D., F.A.C.P.Search for more papers by this author, W. NEWLON TAUXE, M.D.Search for more papers by this author, GEORGE A. HALLENBECK, M.D.Search for more papers by this author, ROY G. SHORTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-1-105 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn patients with renal allografts, serial determinations of renal function are of prognostic significance. Trends in renal function may be considered as reflecting a balance between effective immunosuppressive therapy on one hand, and the immunologic response—that is, the rejection process—on the other (1). A stable or upward trend in renal function indicates that rejection is being successfully controlled. A downward trend indicates the need for increased immunosuppressive therapy, if mechanical obstructive and infectious causes have been eliminated.An important aspect in the long-term care of these patients is to establish an optimal antirejection drug program; and, as a proper guideline...References1. STARZL TE: Experience in Renal Transplantation. W. B. Saunders Co., Philadelphia, 1964. Google Scholar2. MOBLEYSCHLEGEL JEJU: Radiohippuran accumulation in the transplanted kidney as a signal of rejection. Surgery 58: 815, 1965. MedlineGoogle Scholar3. STARZLMARCHIOROTERASAKIPORTERFARISHERRMANNVREDEVOEHUTTOGDENWADDEL TETLPIKATDTJDLMPDAWR: Chronic survival after human renal homotransplantation. Lymphocyte-antigen matching, pathology and influence of thymectomy. Ann. Surg. 162: 749, 1965. CrossrefMedlineGoogle Scholar4. DUNEANAKAMOTOSTRAFFONKOLFF GSRAWJ: Kidney transplantation—1964. Arch. Intern. Med. (Chicago) 116: 234, 1965. CrossrefMedlineGoogle Scholar5. WAGONERTAUXEMAHERHUNT RDWNFTJC: Measurement of effective renal plasma flow with sodium iodohippurate I-131. JAMA 187: 811, 1964. CrossrefMedlineGoogle Scholar6. TAUXEBURBANKMAHERHUNT WNMKFTJC: Renal clearances of radioactive ortho-iodo-hippurate and diatrizoate. Mayo Clin. Proc. 39: 761, 1964. MedlineGoogle Scholar7. FARMERTAUXEMAHERHUNT CDWNFTJC: Measurement of renal function with radioiodinated diatrizoate and orthoiodohippurate. Amer. J. Clin. Path. January 1967. CrossrefMedlineGoogle Scholar8. SAPIRSTEINVIDTMANDELHANUSEK LADGMJG: Volumes of distribution and clearances of intravenously injected creatinine in the dog. Amer. J. Physiol. 181: 330, 1955. CrossrefMedlineGoogle Scholar9. BONSNESTAUSSKY RWHH: On the colorimetric determination of creatinine by the Joffe reaction. J. Biol. Chem. 158: 581, 1945. CrossrefGoogle Scholar10. SMITH HW: The Kidney: Structure and Function in Health and Disease. Oxford University Press, New York, 1951. Google Scholar11. FRIEDMANSELZERKREUTZMANNSAMPSON MAHJJ: The changes in the blood pressure and in the renal blood flow and glomerular filtration rate of hypertensive patients following unilateral nephrectomy. J. Clin. Invest. 21: 19, 1942. CrossrefMedlineGoogle Scholar12. HOGEMAN O: Clearance tests in renal disorders and hypertension. Acta Med. Scand. 132 (suppl. 216a): 1948. Google Scholar13. KOUNTZLAUBCOHN SLDRR: Detecting and treating early renal homotransplant rejection. JAMA 191: 997, 1965. CrossrefMedlineGoogle Scholar14. SHORTERTITUSMARCEAUHALLENBECK RGJLJPGA: Renal homotransplantation in dogs. J. Surg. Res. 4: 537, 1964. CrossrefMedlineGoogle Scholar15. KOUNTZWILLIAMSWILLIAMSKAPROSDEMPSTER SLMAPLCWJ: Mechanism of rejection of homotransplanted kidneys. Nature (London) 199: 257, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES V. DONADIOJR., M.D.; CHARLES D. FARMER, M.D.; JAMES C. HUNT, M.D., F.A.C.P.; W. NEWLON TAUXE, M.D.; GEORGE A. HALLENBECK, M.D.; ROY G. SHORTER, M.D.Affiliations: Rochester, MinnesotaFrom the Mayo Clinic and Mayo Foundation and the Mayo Graduate School of Medicine (University of Minnesota), Rochester, Minn.This investigation was supported in part by research grant HE-0895, the National Institutes of Health, Bethesda, Md.Drs. Donadio and Farmer were recipients of postdoctoral training grants F2-HE-24 and F2-HE-20, respectively, from the National Institutes of Health, Bethesda, Md.This paper was read at the regional meeting of the American College of Physicians, Madison, Wis., October 16, 1965.Requests for reprints should be addressed to James C. Hunt, M.D., Mayo Clinic, Rochester, Minn. 55901. 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OGDEN, M.D.Technetium-99m(V)–Citrate Complex for Estimation of Glomerular Filtration RateGeneral Health and Renal Function in Kidney Transplantation Donors 8–30 Months after NephrectomyRadionuclides in Urology 1 January 1967Volume 66, Issue 1Page: 105-115KeywordsBlood plasmaDrugsGraduate medical educationImmunosuppressivesLong-term carePatientsResearch grants ePublished: 1 December 2008 Issue Published: 1 January 1967 PDF downloadLoading ...