tbuckley/cabot-search huggingface dataset:
413 LONG-TERM DEFERASIROX THERAPY IS ASSOCIATED WITH STABILIZATION OR IMPROVEMENT OF LIVER FIBROSIS AND NECROINFLAMMATION IN PATIENTS WITH ß-THALASSEMIA REGARDLESS OF HEPATITIS C STATUS
Authors: Y. Deugnier, B. Turlin, M. Ropert, V. Dong, V. Giannone, Y. Zhang, L. Griffel, P. Brissot
Journal: Journal of Hepatology (2011)
GVHD and prognostic factors
Authors: Francesca Bonifazi, Giuseppe Bandini, Maddalena Giovannini, Sadia Falcioni, Michele Baccarani
Journal: American Journal of Hematology (2006)

Combination Therapy With rFVIIa and Platelets for Hemorrhage in Patients With Severe Thrombocytopenia and AlloimmunizationTo the Editor: Recombinant factor VIIa (rFVIIa) is approved in the U.S. for treatment of bleeding in hemophiliacs with inhibitors.It has also been used in a small number of patients with severe thrombocytopenia who were refractory to platelets [1], but its efficacy has not been well established in this setting.We cared for 2 patients with life-threatening bleeding, thrombocytopenia, and platelet refractoriness who had dramatic clinical responses to the combination of platelet transfusions and a single dose of rFVIIa.Patient 1 is 61-year-old male with severe aplastic anemia (SAA) who was refractory to platelet transfusions due to severe alloimmunization.He developed sudden, acute, severe gastrointestinal bleeding and hypotension, losing more than 500 mL of bright red blood per rectum (BRBPR).His platelet count was 2000/mL.He received 7 units of PRBC, 36 units of
Occurrence of mites in Norway and the rest of Scandinavia
Authors: R. Mehl
Journal: Allergy (1998)

This paper gives a faunistic review of mites that have been recorded in the indoor environment, particularly homes, barns, and stored products, in Norway and the other Scandinavian countries. Some preliminary results are given from unpublished investigations in Norway. Seven species of pyroglyphid mites have been recorded: Dermatophagoides pteronyssinus, D. microceras, D. farinae, D. evansi, Euroglyphus maynei, Gymnoglyphus longior, and Hirstia chelidonis. D. pteronyssinus was the predominant species, followed by D. microceras in Scandinavia and D. farinae in Denmark. D. evansi was detected in poultry houses in Norway. Lepidoglyphus destructor was the predominant species in barn dust, but large populations of Acarus, Tyrophagus, Tydeus, and Tarsonemidae also occurred. In humid homes, Glycyphagus domesticus was found in high numbers. The result of quantification of mites depends on the method for examination of dust. When one proposes limits for the concentration of mites in relation to risk of allergic sensitization and provocation of symptoms, reference should be made to a well-described method for sampling and analyzing dust. The number of mites should be given per area, not only per weight unit of dust. The number of mites per area indicates the number of mites in the home. The number of mites per weight unit of dust describes the concentration of mites in the vacuum cleaner.
The Diagnosis of Anastomotic Leak After Gastroesophagostomy With Biliary Scintigraphy
Authors: KRISTIAN HERRLIN
Journal: Clinical Nuclear Medicine (1995)

Tc-99m HIDA scintigraphy in a patient with septic complications after partial resection of the esophagus and gastroesophagostomy demonstrated a free bile leak through the anastomosis to the thoracic drains. Concomitant attempts to verify this with dye ingestion (methylene blue) and x-ray examinations were negative.
Death rates and causes of death in 284 consecutive patients with giant cell arteritis confirmed by biopsy.
Authors: E. Nordborg, B. A. Bengtsson
Journal: BMJ (1989)

available for the conditions being sought, resulting in overall benefit for the patient.While we accept that changes in the practices for preschool vision screening are obviously needed, the "knock on", effect of such changes on diagnostic services in terms of workload and cost will need to be taken into account.More importantly, the effects of early treatment of low vision, squint, refractive error, and amblyopia in very young children need to be clarified.
IN A SWINE MODEL OF VF CARDIAC ARREST THE VF WAVEFORM PREDICTS A RETURN OF SPONTANEOUS CIRCULATION AND CAN DISTINGUISH AN ACUTE FROM POST MYOCARDIAL INFARCTION STATE
Authors: Julia H. Indik, Daniel Allen, Michael Gura, Christian Dameff, Ronald W. Hilwig, Karl B. Kern
Journal: Journal of the American College of Cardiology (2011)
A practical outline for preparing medical talks and papers.
Authors: M. Therese Southgate
Journal: JAMA (1963)

ABSTRACT Most editors of medical journals have been known occasionally to harbor some dark thoughts against writers, especially against those who submit manuscripts with poorly prepared illustrations. We strongly suspect that similar dire phantasies occupy  minds of many of those who must strain to see  slides presented by speakers at medical meetings. While our courtesy constrains us and prevents our wishes from becoming actions, we nevertheless envy our printers, who can dispose of broken type in a box they call the hell. Unhappily, editors have no hellbox.In an effort to redeem some of these erring writers and speakers, Dr. Robert M. Zollinger, who is himself a journal editor, Dr. William G. Pace of  Department of Surgery, and Mr. George J. Kienzle of  School of Journalism, all at Ohio State University, have written A Practical Outline for Preparing Medical Talks and Papers. In 57 pages, half of
Rising incidence of childhood diabetes.
Authors: J O Craig, J A Ford, A C McCuish
Journal: BMJ (1977)

Together with colleagues in the University of Dundee I am completing an analysis of views of a one-in-eight sample of Scottish general practitioners concerning the consultation.From this it is clear that GPs (and a sizable proportion in the survey were not college members) do not share Dr Raine Roberts's view (p 508) on the consultation.There is very strong support for helping new entrants to general practice to readjust their approach to clinical medicine to suit the different circum- stances of general practice.
HYPERTENSION DUE TO RENAL EMBOLISM
Authors: ARTHUR M. FISHBERG
Journal: JAMA (1942)

Since 1938 I<sup>1</sup>have observed 4 cases in which embolization of one or both renal arteries was followed by a pronounced rise in arterial pressure. Prinzmetal<sup>2</sup>has studied a similar case in detail. Since the 4 cases observed in the span of four years were detected without special search in the course of routine ward work, it would appear that hypertension is more than a rare manifestation of renal embolism. For this reason, and because of the theoretical and practical connotations of the elevation of blood pressure occasioned by embolic plugging of a renal artery, the cases seem worthy of publication. <h3>Case 1.—</h3> T. H., a man aged 42, was admitted on Oct. 22, 1938. He had felt entirely well until three weeks before admission, when he suddenly had severe constricting substernal pain which radiated down the right arm. Accompanying the pain were extreme apprehension and moderate shortness
TRAVEL NOTES. V.ITALY AND THE GREAT ANTIMALARIAL CAMPAIGN.
Authors: LEWELLYS F. BARKER
Journal: JAMA (1904)

In Italy and Sicily as in Spain, the medical traveler is prone to pay more attention to, and profit more from, the history and art of the land than its medicine. And this with right; the key to the history of Europe is to be sought in Rome, and who would know Rome must study Sicily. And yet the physician traveling in Italy, who gave himself over entirely to the satisfaction of his historical and esthetic inclinations, would miss much, for Italy has recently been making great strides forward commercially, socially and scientifically. Especially is this true of northern Italy, which presents a marked contrast to the southern regions where poverty depresses, begging still annoys and dishonesty yet exasperates the American traveler. That the country is everywhere and in almost all particulars making a swing upward is obvious. The national credit is much improved, as the traveler finds, almost to
Functions of the Median-Eminence Gland
Authors: Seymour Reichlin
Journal: New England Journal of Medicine (1966)

DR. Hiatt asked me to change the title, "Functions of the Median-Eminence Gland," because he was afraid that no one would know what I was talking about — whether it was the prostate gland or some other subject that is both medial and eminential. I have chosen this title to emphasize the fact that the median eminence forms a glandular part of the brain, which has as its function the regulation of the anterior pituitary gland, just as the neurohypophysis is a neural gland whose secretions affect kidney, uterus and breast. This theme will be illustrated by recent observations about . . .
Regulation of the expression of the hematopoietic stem cell antigen CD34: role of c-myb.
Authors: P Melotti, D H Ku, B Calabretta
Journal: The Journal of Experimental Medicine (1994)

The CD34 antigen defines a subset of hematopoietic progenitor cells with self-renewal capacity and the ability to reconstitute hematopoiesis in irradiated primates and marrow-ablated humans, but its function remains unknown. The c-myb protooncogene plays a fundamental role in hematopoiesis, most likely via its transcriptional regulator function. We report that c-myb protein transactivates the CD34 promoter via specific interaction with multiple Myb binding sites in the 5' flanking region of the gene and induces expression of the endogenous CD34 mRNA in rodent fibroblasts. Also, constitutive expression of c-myb in CD34-negative human glioblastoma cells induces expression of CD34 mRNA and synthesis of the surface membrane antigen. These data directly demonstrate that c-myb regulates the expression of the hematopoietic stem cell antigen CD34 and raise the possibility that c-myb regulates hematopoiesis inducing a cascade of differentiation-related events.
Effect of methacholine induced bronchoconstriction on the pulmonary distribution and plasma pharmacokinetics of inhaled sodium cromoglycate in subjects with normal and hyperreactive airways.
Authors: R Richards, A Haas, S Simpson, A Britten, A Renwick, S Holgate
Journal: Thorax (1988)

Inhalation treatment may be less effective in the presence of bronchoconstriction because of the reduced penetration of drugs into the airways. The effect of bronchoconstriction on the lung deposition and plasma pharmacokinetics of inhaled sodium cromoglycate was examined. Ten subjects attended the laboratory on three occasions. On the first occasion a bronchial provocation test was performed to determine the concentration of methacholine required to reduce the forced expiratory volume in one second (FEV1) by 20% (PC20). On the two subsequent occasions subjects inhaled either saline or their PC20 methacholine, followed five minutes later by an aerosol containing sodium cromoglycate and stannous phytate labelled with technetium-99m. Twenty minutes later a gamma emission lung scan was performed to determine the intrathoracic deposition of the nebulised aerosol. The central:peripheral (C:P) ratio of lung deposition was then calculated. Measurements of FEV1 were made and blood samples taken for analysis of plasma sodium cromoglycate concentration at intervals for four hours. Methacholine led to a 23.4% (SEM 0.6%) lower FEV1 and a 2.8 times higher C:P ratio than those observed after saline. There was a direct correlation between log PC20 methacholine and the increase in the C:P ratio (r = 0.81). Despite these changes with methacholine, the plasma pharmacokinetics of inhaled sodium cromoglycate were not significantly different after methacholine and after saline, except that the maximum concentration achieved (Cmax) was increased. These observations suggest that the area of cromoglycate deposition and the anatomical site are less important in determining the plasma pharmacokinetics of cromoglycate than is the total dose delivered to the lung.
Postvaccinial Perivenous Encephalitis
Authors: Bernard J. Alpers
Journal: JAMA (1960)

This little monograph constitutes a good survey of the problem of postvaccinal encephalitis, based on autopsied cases of the disease occurring in the Netherlands since 1925 and on a survey of the pertinent literature. It is the author's contention that the encephalitis following vaccination is a special microglial encephalitis but that this is not seen exclusively following vaccination. It is also seen after measles and, rarely, following rubella and varicella. Associated with microbial encephalitis is a special clinical picture. The condition was rarely seen before 1923 and is never found in children under 2 years of age. The disease sometimes follows revaccination. The specific type of microglial encephalitis with its characteristic clinical features must be separated from other forms of postvaccinial encephalitis. These may simulate true postvaccinial encephalitis but are associated with other pathological features. The monograph reflects the study of rich material. It is a good survey of the
STIMULATION OF ANTIBODY PRODUCTION TO THE HAPTEN 2,4-DINITROBENZENE BY AFFINITY LABELED MURINE LYMPHOID CELLS
Authors: David A. Lawrence, William O. Weigle
Journal: The Journal of Experimental Medicine (1974)

The ability of meta-nitrobenzenediazonium fluoborate (m-NBDF)-labeled thymus and spleen (S) cells to transfer immunity to 2,4-dinitrophenyl (DNP) into irradiated syngeneic recipients was investigated. There was a significant increase in the number of anti-DNP plaque-forming cells (PFC) when m-NBDF-labeled thymus cells and normal spleen cells, or normal thymus cells and m-NBDF-labeled spleen cells were transferred, but not when both thymus- and S-cell populations were labeled and injected together into irradiated recipients. The ability of these cell populations to cooperate and enhance the in vivo immune response to DNP is discussed. The T cells seem to be actively involved in the development of this response; they participate beyond the mere role of carrying and presenting antigen to the B cells. It is suggested that cell to cell contact between T and B cells may be an important factor in the elicitation of an immune response. In addition, the cellular interaction is affected by irradiating the thymus cell preparation and the initiating interaction required for antibody synthesis probably occurs within 48 h after injecting the cell populations into the syngeneic irradiated recipients.
Characterization of a germline Vk gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus.
Authors: N Suzuki, T Harada, S Mihara, T Sakane
Journal: Journal of Clinical Investigation (1996)

We found previously that cationic anti-DNA autoantibodies (autoAbs) have nephritogenic potential and usage of a specific germline Vk gene, A30, has major influences on cationic charge of the autoAb in human lupus nephritis. In the present study, we have characterized A30 germline Vk gene using cosmid cloning technique in patients with SLE. A30 gene locus locates in less than 250 kb from the Ck region, and the cationic anti-DNA mRNA used the upstream Jk2 gene, indicating that cationic anti-DNA mRNA is a product of primary gene rearrangement. By using PCR technique, we found that A30 gene locus in the genome was defective in eight out of nine SLE patients without nephritis. In contrast, all nine patients with lupus nephritis had intact A30 gene. The presence and absence of A30 gene was associated with the development of lupus nephritis or not (P < 0.01, by Fisher's exact test, two-sided). It was thus suggested that absence of functional A30 gene may rescue from developing lupus nephritis in the patients. A30 is reported to be a potentially functional but rarely expressed Vk gene in humans. It is possible that normal B cells edit primarily rearranged A30 gene with autoreactive potentials by receptor editing mechanism for changing the affinity of the B cell Ag receptor to avoid self-reactivity, whereas SLE B cells may have a defect in this mechanism. Indeed, we found that normal B cells edit A30-Jk2 gene in their genome possibly by inversion mechanism, whereas SLE B cells contain rearranged A30-Jk2-Ck gene in the genome and express A30-associated mRNA, suggesting that receptor editing mechanism is also defective in patients with SLE. Our study suggests that polymorphism of Ig Vk locus, and failure of receptor editing may contribute to the development of pathogenic anti-DNA responses in humans.
Diagnosing Streptococcal Pharyngitis-Reply
Authors: Robert D. Schrantz
Journal: JAMA (1992)

In Reply.  —Drs Kaplan and Amren find it surprising that our data make  point that the single culture is not good enough, despite more than three decades of experience showing just  opposite.  We have, for 8 years, used two plates, blood agar incubated aerobically (5% to 10% carbon dioxide to enhance recovery of group C streptococci) and blood agar with trimethoprim-sulfamethoxazole (TMP-SMX) incubated anaerobically. Based on  work of others, we expected this to be more sensitive and found it to be so. Viridans streptococci suppress group A β-hemolytic streptococci (GABHS), reportedly mediated by bacteriocins.1With appropriate thymidine concentration,2TMP-SMX agar inhibits viridans streptococci. In anaerobic incubation, added TMP-SMX inhibits commensal β-hemolytic anaerobes. We were influenced by Gunn et al,3who reported that in 6200 cultures aerobic TMP-SMX recovered nearly twice as many GABHS as did plain blood agar (593 vs 338). We were also
Reforming the Financing and Governance of GME
Authors: Gail R. Wilensky, Donald M. Berwick
Journal: New England Journal of Medicine (2014)

Interview with Dr. Gail Wilensky on recommendations for changing the financing of U.S. graduate medical education. (19:23)Download The Institute of Medicine Committee on the Governance and Financing of Graduate Medical Education recommends that Medicare GME funding (updated for inflation) should continue for at least the next 10 years — assuming that five key reforms are undertaken.
Distance to Water Sources Affects Child Health
Authors: M. J. Friedrich
Journal: JAMA (2012)

Reducing the time needed to haul water from source to home can improve the health of children younger than than 5 years of age in sub-Saharan Africa, report researchers from Stanford University, in Stanford, Calif (Pickering AJ and Davis J. Environ Sci Tech. 2012;46[4]:2391-2397).
Influence of the Secretor and Lewis Genes on Susceptibility to Duodenal Ulcer
Authors: P. A. J. Ball
Journal: BMJ (1962)

Human duodenal mucosal cells have been examined by mixed-cell agglutination for the presence of blood- group antigens.The secretor status of the patients has been determined, and in a proportion of cases gastric juice as well as saliva has been studied.Mixed-cell agglutination has also been performed on the buccal cells from a percentage of subjects as a control of technique.The results indicate that antigen is present in secretor subjects, but is absent or very scanty in at least a proportion of non-secretor individuals.The possible relevance of this finding to the problem of duodenal ulcerogenesis is examined.This work formed part of a project the results of which were submitted as a thesis for the degree of M.D.
P158 Endothelial progenitor cells form biological exclusion barriers similar to that of mature endothelial cells- A therapeutic potential in systemic sclerosis?
Authors: RWG Good, SLT Trinder, BAA Abdi, RY Yu, CPD Denton, DJA Abraham, AMH Holmes
Journal: Thorax (2013)

<h3>Abstract</h3> Vascular complications associated with systemic sclerosis (SSc) including pulmonary arterial hypertension (PAH-SSc), result from endothelial damage and loss of barrier function. Endothelial progenitor cells (EPCs) express endothelial (VEGFR2<sup>+</sup>, CD31<sup>+</sup> ) and haematopoietic (CD133<sup>+</sup> ) markers. They home to sites of vascular injury and differentiate into endothelial cells restoring the endothelium. In SSc patients circulating levels of EPCs are reduced. This study aimed to develop a robust method to grow EPCs from peripheral blood mononuclear cells (PBMCs) and to compare cellular functions to mature endothelial cells. <h3>Methods</h3> EPCs and human pulmonary artery endothelial cells (hPAECs) were seeded into transwell inserts and grown to confluence. Cells were incubated with TNFa (50ng/ml), and their capacity to form biological barriers assessed using FITC-albumin (5mg/ml). FITC-albumin ‘leak’ was quantified by fluorescent absorbance over time. We further assessed the responses of EPCs to TNFa stimulation by ELISA to quantify pro-inflammatory cytokine release. <h3>Results</h3> EPCs form a biological exclusion barrier with similar capabilities as mature hPAECs. TNFa significantly enhanced the permeability of EPCs (P &lt; 0.05) and hPAECs (P &lt; 0.05) monolayers. There is no difference in EPC colony formation between HC and SSc EPCs. <h3>Discussion</h3> We developed a robust method for isolating EPCs from PBMCs. We have demonstrated that EPCs can maintain an endothelial barrier consistent with that observed by mature hPAECs <i>in vitro</i>. We have established that EPCs respond to TNFa in a similar manner to mature PAECs. We have shown no significant difference in the capacity of PBMCs from SSc patients to form EPC colonies compared to HCs.