Minimal-Change Disease and the Nephrotic Syndrome Associated with Lithium Therapy
Authors: ALAN V. RICHMAN, HOWARD L. MASCO, STEPHEN I. RIFKIN, M. K. ACHARYA
Journal: Annals of Internal Medicine (1980)

Brief Reports1 January 1980Minimal-Change Disease and the Nephrotic Syndrome Associated with Lithium TherapyALAN V. RICHMAN, M.D., HOWARD L. MASCO, M.D., STEPHEN I. RIFKIN, M.D., M. K. ACHARYA, M.D.ALAN V. RICHMAN, M.D., HOWARD L. MASCO, M.D., STEPHEN I. RIFKIN, M.D., M. K. ACHARYA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-70 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLithium is widely used in psychiatric practice to treat manic-depressive disorders. A variety of adverse renal manifestations secondary to lithium have been reported, including renal failure associated with acute intoxication (1) and nephrogenic diabetes insipidus (2). Recently an association has been found between long-term lithium therapy and chronic tubulointerstitial nephropathy (3).The nephrotic syndrome is a virtually unmentioned adverse effect of lithium. In the French literature, Duflot and colleagues (4) discuss the case of a patient who developed marked albuminuria while taking lithium. The albuminuria subsided after the drug was withdrawn. In the English literature, only Masco, in a personal...References1. LAVENDERBROWNBERRILL SJW. Acute renal failure and lithium intoxication. Postgrad Med J. 1973;49:277-9. CrossrefMedlineGoogle Scholar2. FORRESTCOHENTORRETTIHIMMELHOCHEPSTEIN JAJJF. On the mechanism of lithium-induced diabetes insipidus in man and the rat. J Clin Invest. 1974;53:1115-23. CrossrefMedlineGoogle Scholar3. HESTBECHHANSENAMDISENOLSEN JHAS. Chronic renal lesions following long-term treatment with lithium. Kidney Int. 1977;12:205-13. CrossrefMedlineGoogle Scholar4. DUFLOTDOREFELLION JCG. L'utilisation du carbonate de lithium dans une institution psychiatrique. Ann Med Psychol (Paris). 1973;131:311-21. Google Scholar5. DENBER H. Textbook of Clinical Psychopharmacology. New York: Stratton Intercontinental Medical Book Corp.; 1979:186. Google Scholar6. LINDOPPADFIELD GP. The renal pathology in a case of lithium-induced diabetes insipidus. J Clin Pathol. 1975;28:472-5. CrossrefMedlineGoogle Scholar7. BURROWSDAVIESKINCAID-SMITH GBP. Unique tubular lesion after lithium. Lancet. 1978,1:1310. Letter. CrossrefMedlineGoogle Scholar8. MARTINEZ-MALDONADOTERRELL MJ. Lithium carbonate-induced nephrogenic diabetes insipidus and glucose intolerance. Arch Intern Med. 1973;132:881-4. CrossrefMedlineGoogle Scholar9. HOGERSHONPINCKNEY ASL. The effects of acute and prolonged lithium treatment on the distribution of electrolytes, potassium and sodium. Arch Int Pharmacodyn Ther. 1970;186:54-65. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLithium toxicity and the kidney with special focus on nephrotic syndrome associated with the acute kidney injury: A case‐based systematic analysisRecurring Nephrotic Syndrome After Lithium MedicationNephrotoxicity of Lithium and Drugs of AbuseDrug-induced nephropathiesDrug-Induced Glomerular Disease: Direct Cellular InjuryLithiumSpecific EtiologiesImmune and Inflammatory Glomerular DiseasesQuiz Page August 2011Secondary Glomerular DiseaseNephrotoxicity of Lithium and Drugs of AbuseImmune-Mediated and Other Glomerular DiseasesDrug-induced glomerulopathiesSíndrome nefrótico y tratamiento con litioNephrotic syndrome and renal insufficiency associated with lithium therapyNephrotoxicity of xenobioticsLithium Side Effects in the Medically IllUrinary excretion of albumin and retinol-binding protein in lithium-treated patients: a longitudinal studyThe Effects of Lithium on the Human Visual SystemHypoproteinemia Related with Chronic Lithium Therapy in Two PatientsLithiumRenal aspects of lithium toxicityFocal segmental glomerulosclerosis in patients receiving lithium carbonateEffects of long-term lithium treatment on kidney function: An overviewPrevalence, Pathogenesis, and Treatment of Renal Dysfunction Associated With Chronic Lithium TherapyAdverse Drug Reactions in the HorseEffect of Lithium on the KidneyNephrotic syndrome and immune complex glomerulonephritis associated with chlorpropamide therapyImmunological Aspects of Renal DiseaseCHRONIC USE OF OPIOIDS AND ANTIPSYCHOTIC DRUGS: SIDE EFFECTS, EFFECTS ON ENDOGENOUS OPIOIDS, AND TOXICITYLithium's effects on the kidneyLithiumThe Effect of Lithium Chloride on Renal Structure and Sodium-potassium-adenosine Triphosphatase Activity in DogsCase 17-1981Lithium and the kidneyLithiumToxic nephropathy from diagnostic and therapeutic agents 1 January 1980Volume 92, Issue 1Page: 70-72KeywordsDrugsIntoxicationRenal failure Issue Published: 1 January 1980 Copyright©1980 American College of PhysiciansPDF DownloadLoading ...