tbuckley/cabot-search huggingface dataset:
Authors Generate Authors
Authors: Peter Manu, Stephen A. Landaw, William J. Williams, Sheldon E. Schwartz
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 January 1983Authors Generate AuthorsPETER MANU, M.D., STEPHEN A. LANDAW, M.D., WILLIAM J. WILLIAMS, M.D., SHELDON E. SCHWARTZ, M.D.PETER MANU, M.D.Search for more papers by this author, STEPHEN A. LANDAW, M.D.Search for more papers by this author, WILLIAM J. WILLIAMS, M.D.Search for more papers by this author, SHELDON E. SCHWARTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-108_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The editorial by Burns (1) on manpower needs for academic medicine emphasizes intellectual stimulation as an incentive for research activities. We evaluated intramural research incentives by correlating the publication output of our Department of Medicine faculty with sectional organization, age of the faculty, and changing career goals.From 1 July 1975 through 30 June 1980, 56 fulltime faculty members had been employed in our department for least 2 years. The department has nine subspecialty sections and a general internal medicine section. Articles published in refereed periodicals and invited contributions by our faculty during the survey period were...References1. BURNS T. Manpower needs for academic medicine [Editorial]. Ann Intern Med. 1982;97:611-2. LinkGoogle Scholar2. FRAMENARIN JF. NIH funding and biomedical publication output. Fed Proc. 1979;35:2529-32. Google Scholar3. KRUMLANDWILLSORRY REG. Scientific publications of a medical school faculty. J Med Educ. 1979;54:876-84. MedlineGoogle Scholar4. BLACKBURNFOX RT. The socialization of a medical school faculty. J Med Educ. 1976;51:806-17. MedlineGoogle Scholar5. PEARSEPEOPLESFLORAFREEMAN WERR. Medical school faculty productivity. J Med Educ. 1976;51:201-2. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuantitative studies of science. A current bibliography 1 January 1983Volume 98, Issue 1Page: 108-108KeywordsAcademic medicineBurnsMotivationSub-specialty care Issue Published: 1 January 1983 PDF downloadLoading ...
Board Eligible? Unreal!
Authors: Michael F. Cleary
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Is there a status of "board eligible"? The American Board of Medical Specialties does not endorse any such category. While the term "board certified" carries an implied guarantee or avowal that certification can be verified at any time by the certifying board in question, there is no equivalent way to verify or establish the meaning of "board eligible." What does the term "board eligible" mean? If it means whatever the person using it intends it to mean, it lends a subjective element to the assessment of credentials. Board certification, on the other hand, represents the attainment, at least once, of an objective standard, assessed and measured in open examination. What is troublesome about advertising in<i>JAMA</i>and other journals is that no distinction is made between BE ("board eligible") and BC (board certified). The two are often joined in a misleading acronym BC/BE, with the implication that
Mice with artificial human liver
Authors: Akihide Kamiya, Atsushi Miyajima, Roberto Groszmann, Yasuko Iwakiri, Tamar H. Taddei
Journal: Hepatology (2012)

Kamiya, Akihide Ph.D.; Miyajima, Atsushi Ph.D.; Groszmann, Roberto; Iwakiri, Yasuko; Taddei, Tamar H. Author Information
Richard Asher's resignation: not entirely honourable
Authors: M. W McNicol
Journal: BMJ (2008)

<h3>Background</h3> VISTA (V-domain Ig suppressor of T-cell activation) inhibits anti-tumour immune responses. The Investigational product CI-8993 is a fully human IgG1k monoclonal antibody that binds specifically to this immune checkpoint molecule. Phase I safety has been established in prior trials in patients with advanced cancer (NCT02671955). To assist determining the pharmacokinetics and biodistribution of CI-8993 in patients we aimed to develop a Zirconium-89 (89Zr)-labelled CI-8993 for PET imaging and quantitation, and validate in preclinical models prior to a planned human trial. <h3>Methods</h3> Conjugation conditions of CI-8993 to the metal ion chelator desferrioxamine B (Df-) were established by optimisation of Df:mAb ratio, reaction temperature, time and purification method. Conjugates were assessed by SE-HPLC, SDS-PAGE, and ELISA. Radiolabelling was performed with 89Zr and the radioconjugate was tested for specific activity, radiochemical purity and binding affinity for huVISTA. The in-vivo biodistribution and properties of 89Zr-Df-CI-8993 and IgG1 isotype control radioconjugates were assessed in huVISTA knock-in female (C57BL/6N-Vsir&lt; sup &gt;tm1.1(VSIR)Geno&lt;/sup &gt;) or control C57BL/6 mice bearing syngeneic MB49 bladder cancer tumours. Whole body animal PET/CT imaging was performed on day of radioconjugate synthesis and injection and day 1 and day 3 p.i. Biodistribution was assessed by image analyses, and tissue counting, with IHC analyses performed to verify VISTA antigen expression. <h3>Results</h3> Conjugation of Df- to CI-8993 for 60 minutes at room temperature followed by purification via gel filtration resulted in stable constructs with an average chelator-to-antibody ratio of 1.81. SDS-PAGE showed integrity of CI-8993 was maintained after conjugation, and ELISA indicated no impact of conjugation on binding to human VISTA. Radiochemical purity (iTLC) and protein integrity (SE-HPLC) at EOS were &gt; 99% and 93%. PET imaging and biodistribution in MB49 tumour-bearing huVISTA knock-in female mice showed specific localisation of 89Zr-Df-CI-8993 to VISTA expressing organs (liver: 14.98 ± 0.50 %ID/g; spleen: 292.00 ± 14.51 %ID/g; n = 3) compared to 89Zr-Df-IgG1 control (liver: 4.615 ± 0.15 %ID/g; spleen: 6.37 ± 0.22 %ID/g; n = 4) or in the presence of competing unlabelled CI-8993 (liver: 8.14 ± 0.50 %ID/g; spleen: 41.14 ± 3.00 %ID/g; n = 5). Tumour-to-blood ratios indicated specific tumour targeting of 89Zr-Df-CI-8993 in the presence of unlabelled CI-8993 (20.47 ± 3.09) compared to trace dose 89Zr-Df-CI-8993 (0.97 ± 0.12; P = 0.0001) or 89Zr-Df-IgG1 control (1.75 ± 0.11; P &lt; 0.0001). <h3>Conclusions</h3> We have validated 89Zr-Df-CI-8993 for specific binding to huVISTA in-vivo. A clinical trial of 89Zr-Df-CI-8993 is planned in solid tumour patients. <h3>Ethics Approval</h3> All animal studies were approved by the Austin Health Animal Ethics Committee and were conducted in compliance with the Australian Code for the care anduse of animals for scientific purposes.
BMA meeting: BMA refuses to reject health bill "in its entirety"
Authors: N. Hawkes
Journal: BMJ (2011)

Doctors at the BMA’s annual meeting have narrowly refused to call for the Health and Social Care Bill to be rejected “in its entirety.”

Hamish Meldrum, the BMA’s chairman of council, had appealed to representatives to vote against the motion, and he got his way. But it was a close run thing, with 45% of those voting calling for outright rejection and 54% opposing the motion.

So the annual meeting followed the earlier special representative meeting in sustaining the BMA’s engagement with the bill while demonstrating that doctors are split almost down the middle over whether anything worthwhile can be rescued from it.

The refuseniks, led by Jacqueline Davis of the BMA council, had struggled even to get their “entirety” motion tabled. The agenda included a series of motions suggesting further changes to the bill, including one that called (among other things) on the …
Points from letters: Natural curing of tobacco and lung cancer
Authors: G Y Caldwell
Journal: BMJ (1977)

should be deprived of benefit from their husbands' war service.Interest at 3-50o compound, without tax relief, payable to secure war service pension compares very unfavourably with the miserable 210O simple-taxable-paid since 1948 on our compensation for loss of goodwill.A colleague of mine with six years of war service recently wrote to the appropriate department of the Ministry of Defence seeking confirmation of the dates of his war service.I understand th'at the reply
A National Health Program
Authors: Ronald Bronow
Journal: JAMA (1990)

DOCTORS Woolhandler and Himmelstein,<sup>1</sup>in their Commentary in the October 20, 1989, issue ofThe Journal, argue that a national health program based on the Canadian system is the best solution to the crisis in American health care financing. The authors, however, fail to recognize the negative repercussions of such a system, the consequences of which are now being fully realized in Canada. The province of Saskatchewan started compulsory universal health insurance in 1961. The same province was among the first to announce it had run out of money for medical care services for 1987 and would be unable to pay for them for the rest of the year. Following a funding freeze imposed by Premier Grant Devine's Conservative government, Saskatchewan's hospitals faced a critical shortage of beds, with 1870 patients waiting for surgery at Saskatoon's University Hospital alone (<i>Macleans</i>. February 13, 1989:32).
Hyperglycemic Crises in Adult Patients With Diabetes
Authors: Keigo Yasuda, Hiromichi Tanahashi, Makoto Hayashi, Noriyoshi Yamakita
Journal: Diabetes Care (2009)

In their consensus statement on hyperglycemic crises in adult patients with diabetes, Kitabchi et al. (1) indicated the diagnostic and severity criteria for diabetic ketoacidosis (DKA) due to arterial pH (7.25 to 0.30, 7.00 to <7.24, and <7.00) and serum bicarbonate (15 to 18, 10 to <15, and <10 mEq/l) levels. DKA is one of the most common acid-base …
Deodorisation in Carcinoma Uteri
Authors: T. Skinner
Journal: BMJ (1859)

CASE VI. A. H., a labourer, aged 27, was admitted under my care on May 1st, 1859, suffering from long standing scrofulous disease of the right knee.He was pale and thin, being wasted from much pain; but otherwise he was in good health.History.Eight years back, the disease originated in a blow.He was under surgical treatment for various periods during this time; and, about two years since, was under my care in the hos- pital.At that time, the use of issues, and absolute rest to the limb, sufficed to control the disease; and he was enabled to leave at the end of two months, free from pain; and to get about by the aid of crutches and a support for the knee.He remained well, with the good prospect of a stiff knee, for eighteen months.It then again became painful, and increased in size, so that, his health beginning to suffer, he determined to submit to amputation, and accordingly sought the hospital once again with this view.On examination, the joint was observed to be evenly en- larged, all the bony prominences having disappeared, and an uniformll whitish pulpy appearance being presented.The limb was straight; but the least movement of the joint, or pressure of the patella, occasioned acute pain.Alay 18th.I excised the joint, in preference to amputation.Tlle operation was accomplished in the customary manner, half an inch of the femur, and the same amount of the tibia, being sawn off, and the patella being likewise removed.There was rather abundant hmemorrhage, a large superior external arti- cular artery requiring a ligature.
Benefits of viewing the body
Authors: S. Tarassenko
Journal: BMJ (2010)

<h3>Background</h3> Overweight, obesity is rapidly increasing among children in United Arab Emirates (UAE). This study aimed to determine the prevalence of depression and its relation with obesity in adolescents. <h3>Methods</h3> The study sample included 1018 adolescents (12–18 years) from a random sample of 8 schools out of 114 schools in Al Ain district of Abu Dhabi Emirate in UAE. We estimated self-reported symptoms of depression using the Arabic Beck’s Depression Inventory (BDI). BMI &gt;=85<sup>th</sup> and ≥95<sup>th</sup> percentiles were used to define overweight and obesity according to the 2000 CDC growth charts. <h3>Results</h3> The prevalence of depression according to the BDI (cut-offpoint:19) was 10.7%. Girls were more likely (OR=3.97, 95%CI: 1.11–14.23) to have depression (12.2%) compared to boys (7.0%). A high proportion of adolescents (33.8%) were overweight and obese. There was a significant (p=0.047) correlation between overweight and obesity and depression after adjustment for gender, age, ethnicity and income level. <h3>Conclusion</h3> There is disparity in prevalence of depression by gender. There is significant correlation between overweight, obesity and depression irrespective of age, gender, ethnicity and income.
Obesity Clues From Marmots?
Authors: Tracy Hampton
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of outdoor airborne particulate matter on daily death counts.
Authors: P Styer, N McMillan, F Gao, J Davis, J Sacks
Journal: Environmental Health Perspectives (1995)

To investigate the possible relationship between airborne particulate matter and mortality, we developed regression models of daily mortality counts using meteorological covariates and measures of outdoor PM10. Our analyses included data from Cook County, Illinois, and Salt Lake County, Utah. We found no evidence that particulate matter < or = 10 microns (PM10) contributes to excess mortality in Salt Lake County, Utah. In Cook County, Illinois, we found evidence of a positive PM10 effect in spring and autumn, but not in winter and summer. We conclude that the reported effects of particulates on mortality are unconfirmed.
Latest figures for England show rise in general practice consultations
Authors: H. Mooney
Journal: BMJ (2009)

<h3>Background</h3> Non-small cell lung cancer (NSCLC) comprises approximately 85% of all lung cancer cases, and surgery is the preferred treatment for patients. The National Health Service established Primary Care Trusts (PCTs) in 2002 to manage local health needs. We investigate whether PCTs with a lower uptake of surgical treatment are those with above-average mortality 1 year after diagnosis. The applied methods can be used to monitor the performance of any administrative bodies responsible for the management of patients with cancer. <h3>Methods</h3> All adults diagnosed with NSCLC lung cancer during 1998–2006 in England were identified. We fitted mixed effect logistic models to predict surgical treatment within 6 months after diagnosis, and mortality within 1 year of diagnosis. <h3>Results</h3> Around 10% of the NCSLC patients received curative surgery. Older deprived patients and those who did not receive surgery had much higher odds of death 1 year after being diagnosed with cancer. In total, 69% of the PCTs were below the lower control limit of surgery and have predicted random intercepts above the mean value of zero of the random effect for mortality, whereas 40% were above the upper control limit of mortality within 1 year. <h3>Conclusions</h3> Our main results suggest the presence of clear geographical variation in the use of surgical treatment of NSCLC and mortality. Mixed-effects models combined with the funnel plot approach were useful for assessing the performance of PCTs that were above average in mortality and below average in surgery.
Liver cirrhosis. Edited by J. L. Boyer and L. Bianchi, 465 pp. Lancaster, England: MTP Press, 1987
Authors: Charles L. Mendenhall
Journal: Hepatology (1988)

Hc patology invites all readers who wish to review books for this journal to indicate their interest by informing the I%ook Editor.If there is a specific subject or subsubject that the potential reviewer prefers, he or she should so ir.dicate.If there is a specific book in press that a readc?r would like to review, a note to this effect should be sent to the Book Editor.Bcok reviews may be of
An Association between Neutrophils and Immunoglobulin Free Light Chains in the Pathogenesis of Chronic Obstructive Pulmonary Disease
Authors: Saskia Braber, Marco Thio, Bart R. Blokhuis, Paul A. J. Henricks, Pim J. Koelink, Tom Groot Kormelink, Gillina F. G. Bezemer, Huib A. M. Kerstjens, Dirkje S. Postma, Johan Garssen, Aletta D. Kraneveld, Frank A. Redegeld, Gert Folkerts
Journal: American Journal of Respiratory and Critical Care Medicine (2012)

Rationale: Neutrophils are key players in chronic obstructive pulmonary disease (COPD), and increased numbers of neutrophils are present in sputum and lung tissue of patients with COPD. Interestingly, immunoglobulin free light chains (IgLC) are able to prolong the life of neutrophils; therefore, IgLC may contribute to the chronic state of inflammation.Objectives: In this study, the relation between IgLC and COPD has been investigated.Methods: We investigated the presence of IgLC in different murine lung emphysema models. IgLC levels in serum from mice and patients with COPD were examined by Western blot analysis and ELISA, respectively. IgLC levels in lung tissue were determined by immunohistochemistry. Fluorescence-activated cell sorter and immunofluorescent analysis were used to detect binding between IgLC and human neutrophils. Interleukin-8 (CXCL8) release by neutrophils after IgLC incubation was measured by ELISA. The effect of F991, an IgLC antagonist, was examined on the neutrophil influx in murine lungs after 5 days of smoke exposure.Measurements and Main Results: Increased levels of IgLC in serum of cigarette smoke–exposed and cigarette smoke extract–treated mice compared with control mice were observed. Patients with COPD showed increased serum IgLC and expression of IgLC in lung tissue compared with healthy volunteers. Interestingly, IgLC bound to neutrophils and activated neutrophils to release CXCL8. F991 inhibited the IgLC binding to neutrophils and reduced the smoke-induced neutrophil influx in murine lungs after smoke exposure.Conclusions: This study describes for the first time an association between neutrophils and IgLC in the pathophysiology of COPD, which could open new avenues to targeted treatment of this chronic disease.
Double-balloon enteroscopy-ERCP rendezvous technique
Authors: K. Mönkemüller, D. Popa, B. McGuire, J. Ramesh, C. Wilcox
Journal: Endoscopy (2013)

Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered upper gastrointestinal anatomy such as Roux-en-Y anastomosis is challenging [1]. The use of double-balloon endoscopy (DBE) for ERCP in patients with surgically altered anatomy has been shown to be safe and feasible [2­ – 4]. Here we present the concept of DBE – ERCP rendezvous technique with combined endoscopic-percutaneous placement of biliary stents in two patients.
Infective Endocarditis in Children With Congenital Heart Disease
Authors: Dinela Rushani, Jay S. Kaufman, Raluca Ionescu-Ittu, Andrew S. Mackie, Louise Pilote, Judith Therrien, Ariane J. Marelli
Journal: Circulation (2013)

The American Heart Association guidelines for prevention of infective endocarditis (IE) in 2007 reduced the groups of congenital heart disease (CHD) patients for whom antibiotic prophylaxis was indicated. The evidence base in CHD patients is limited. We sought to determine the risk of IE in children with CHD.We performed a population-based analysis to determine the cumulative incidence and predictors of IE in children (0-18 years) with CHD by the use of the Quebec CHD Database from 1988 to 2010. In 47 518 children with CHD followed for 458 109 patient-years, 185 cases of IE were observed. Cumulative incidence of IE was estimated in the subset of 34 279 children with CHD followed since birth, in whom the risk of IE up to 18 years of age was 6.1/1000 children (95% confidence interval, 5.0-7.5). In a nested case-control analysis, the following CHD lesions were at highest risk of IE in comparison with atrial septal defects (adjusted rate ratio, 95% confidence interval): cyanotic CHD (6.44, 3.95-10.50), endocardial cushion defects (5.47, 2.89-10.36), and left-sided lesions (1.88, 1.01-3.49). Cardiac surgery within 6 months (5.34, 2.49-11.43) and an age of <3 years (3.53, 2.51-4.96; reference, ages 6-18) also conferred an elevated risk of IE.In a large population-based cohort of children with CHD, we documented the cumulative incidence of IE and associated factors. These findings help identify groups of patients who are at the highest risk of developing IE.
A Reappraisal of Hepatitis B Virus Vaccination Strategies Using Cost-Effectiveness Analysis
Authors: Bernard S. Bloom
Journal: Annals of Internal Medicine (1993)

To determine clinical and economic consequences of alternative vaccination strategies for preventing hepatitis B virus infection (HBV).Decision analysis was used to evaluate costs, outcomes, and cost-effectiveness of three HBV management strategies ("no vaccination," "universal vaccination," and "screen and vaccinate") in four populations (newborns, 10-year-old adolescents, a high-risk adult population, and the general adult U.S. population). Information on HBV incidence and prevalence, clinical course, and management of acute illness and chronic sequelae was obtained from the literature and a panel of experts. Actual payments (costs) were obtained from Blue Cross/Blue Shield and local pharmacies. Incremental cost-effectiveness was calculated from the perspective of the payer of medical care and subjected to sensitivity analysis.Vaccination (with or without screening) prevents more disease at somewhat increased cost than no vaccination for the neonatal, adolescent, and adult populations. Vaccination (with or without screening) is a dominant strategy in adult high-risk populations (lower cost and greater benefit than no vaccination). Optimal cost-effectiveness, with nonmonetary benefits not discounted, results if all pregnant women are screened for active HBV infection, and HBV vaccine and hepatitis B immune globulin are administered to babies born to mothers with positive screening tests. Then HBV vaccine is administered to all children at age 10 and again 10 years later (incremental cost-per-year-of-life-saved relative to the "no vaccination" strategy is $375). A strategy of universal newborn vaccination alone leads to an incremental cost-per-year-of-life saved of $3332. If adolescents are vaccinated at age 10, incremental cost-per-year-of-life saved is $13,938; for the general adult population, the incremental cost-per-year-of-life saved of universal vaccination is $54,524. Discounting benefits will increase cost-per-year-of-life saved 7 to 12 times for all strategies.HBV vaccine is most cost-effective when a strategy of screening newborns is combined with routine administration to 10-year-old children. The means to achieve substantial improvements in the health of the public in a cost-effective fashion are now available and should be pursued aggressively.