Cushing's Syndrome and Corticotropin-secreting Carcinoma of the Lung
Authors: LEON J. MARKS
Journal: Annals of Internal Medicine (1963)

Case Studies1 January 1963Cushing's Syndrome and Corticotropin-secreting Carcinoma of the LungLEON J. MARKS, M.D., DAVID L. ROSENBAUM, M.D., AGNES B. RUSSFIELD, M.D.LEON J. MARKS, M.D.Search for more papers by this author, DAVID L. ROSENBAUM, M.D.Search for more papers by this author, AGNES B. RUSSFIELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-143 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of Cushing's syndrome and carcinoma of the lung has occurred with sufficient frequency to suggest more than a coincidental relationship (1-4). However, the nature of this relationship has not been clear. In some cases, hyperfunction of the adrenal cortex is noted before the carcinoma is discovered, while sometimes the neoplasm appears first (1-4). The idea that the tumor might in some manner stimulate the pituitary to secrete adrenocorticotropin has been suggested by the finding of elevated plasma ACTH levels in several patients (3, 5). However, this finding is also consistent with the concept that the neoplasm itself secretes...References1. ALLOTTSKELTON ENMO: Increased adrenocortical activity associated with malignant disease. Lancet 2: 278, 1960. CrossrefMedlineGoogle Scholar2. BAGSHAWE KD: Hypokalemia, carcinoma, and Cushing's syndrome. Lancet 2: 284, 1960. CrossrefMedlineGoogle Scholar3. BORNSTEINNOLANBERNANKE PJPD: Adrenocortical hyperfunction in association with anaplastic carcinoma of the respiratory tract. New Engl. J. Med. 264: 363, 1961. CrossrefGoogle Scholar4. RIGGSSPRAGUE BLRG: Association of Cushing's syndrome and neoplastic disease. Arch. Intern. Med. 108: 85, 1961. CrossrefGoogle Scholar5. CHRISTY NP: Adrenocorticotrophic activity in the plasma of patients with Cushing's syndrome associated with pulmonary neoplasms. Lancet 1: 85, 1961. CrossrefMedlineGoogle Scholar6. RUSSFIELD AB: Combined bioassay and histologic study of 73 human hypophyses. Cancer 13: 790, 1960. CrossrefMedlineGoogle Scholar7. PLOTZKNOWLTONRAGAN CMAIC: The natural history of Cushing's syndrome. Amer. J. Med. 13: 597, 1952. CrossrefMedlineGoogle Scholar8. CHRISTYLARAGH NPMD: Pathogenesis of hypokalemic alkalosis in Cushing's syndrome. New Engl. J. Med. 265: 1083, 1961. CrossrefMedlineGoogle Scholar9. ROSENBERG AA: Fulminating adrenocortical hyperfunction associated with islet-cell carcinoma of the pancreas. J. Clin. Endocr. 16: 1364, 1956. CrossrefGoogle Scholar10. PARSONSRIGBY VB: Cushing's syndrome associated with adenocarcinoma of the ovary. Lancet 2: 992, 1958. CrossrefMedlineGoogle Scholar11. SCHOLZBAHN DARC: Thymic tumors associated with Cushing's syndrome. Proc. Mayo Clin. 34: 433, 1959. MedlineGoogle Scholar12. DYSON BC: Cushing's disease: report of a case associated with carcinoma of the thyroid gland and cryptococcus. New Engl. J. Med. 261: 169, 1959. CrossrefMedlineGoogle Scholar13. PETERSONWYNGAARDEN REJB: Miscible pool and turnover rate of hydrocortisone in man. J. Clin. Invest. 35: 552, 1956. CrossrefMedlineGoogle Scholar14. SPAULDINGOILLEGORNALL WBWAAG: Mineralocorticoid-like disturbance associated with adrenal metastases from a bronchogenic carcinoma. Ann. Intern. Med. 42: 444, 1955. LinkGoogle Scholar15. ROSS EJ: Modification of the effects of aldosterone on electrolyte excretion in man by simultaneous administration of corticosterone and hydrocortisone. J. Clin. Endocr. 20: 229, 1960. CrossrefGoogle Scholar16. METZLERFLINK CEB: Adrenal cortical hyperfunction associated with bronchogenic carcinoma. J. Lancet 76: 242, 1956. MedlineGoogle Scholar17. BELSKYMARKS JLLJ: Plasma 17-hydroxycorticosteroid responsiveness to ACTH in patients with bronchogenic carcinoma. Metabolism 11: 435, 1962. MedlineGoogle Scholar18. MEADORISLANDNICHOLSONNUCKTONLUCASLUETSCHERLIDDLE CDWJCJG: Severe Cushing's syndrome apparently due to corticotrophin secreting oat cell carcinoma (Abstract). Program presented at the forty-third meeting of the Endocrine Society, New York, June 22-24, 1961, p. 86. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Medical Service and Steroid Research Laboratory, Boston Veterans Administration Hospital, the Tufts University School of Medicine, and the Children's Cancer Research Foundation and the Department of Pathology, Harvard Medical School at the Children's Hospital, Boston, Massachusetts.Bioassays were supported by grant P-232 from the American Cancer Society.Requests for reprints should be addressed to Leon J. Marks, M.D., Steroid Research Laboratory, Veterans Administration Hospital, 150 South Huntington Avenue, Boston 30, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEctopic ACTH syndrome due to islet cell carcinoma in a 12 year old chlidFunctioning Tumors of the GutGastrinoma associated with common bile duct obstruction and the ectopic production of ACTHSecrecion ectopica de acth. Sindrome de cushing paraneoplasico por carcinoma de pulmonParaneoplastic syndromes Resulting from elaboration of ectopic hormones, antigens and bizarre toxinsMedullary cancer of the thyroid gland associated with hypercorticismClinical and Laboratory Studies of Ectopic Humoral SyndromesSteroid hormone abnormalities in patients with carcinoma of the lungOn the Pharmacologic Actions of 21-Carbon Hormonal Steroids (“Glucocorticoids”) of the Adrenal Cortex in MammalsCushing's syndrome caused by bronchial adenomasHormonal Syndromes Associated with NeoplasiaM-proteins, plasmacytosis and cancerThe pathology of the adrenal gland in Cushing's syndromeHyponatremia from inappropriate antidiuretic hormone elaboration in carcinoma of the lungEctopic Production of Multiple Hormones (ACTH, MSH and Gastrin) by a Single Malignant TumorLungentumoren bei jüngeren MenschenCushing's Syndrome in Association with Carcinoma of the Respiratory TractThe production of hypokalemic alkalosis with hydrocortisone in subjects with adrenal insufficiencyExtrathoracic Manifestations of Bronchogenic CarcinomaPsychiatry and General MedicineEndocrine Dysfunction in Malignant DiseasePlasma 17-Hydroxycorticosteroid Responsiveness to ACTH in Patients with Bronchogenic Carcinoma Without Cushing's SyndromeAdrenal-pituitary Studies in a Patient with Bronchogenic Carcinoma and Cushing's SyndromeRICHARD A. PFOHL, M.D., RICHARD P. DOE, M.D. 1 January 1963Volume 58, Issue 1Page: 143-149KeywordsAdrenocorticotropic hormoneBlood plasmaChildrenCortisolExcretionHospital medicineLung and intrathoracic tumorsMedical servicesPathology and laboratory medicineResearch laboratories Issue Published: 1 January 1963 PDF DownloadLoading ...