The Effect of Treatment in Patients with Chronic Myelogenous Leukemia
Authors: PAUL P. CARBONE
Journal: Annals of Internal Medicine (1963)

Article1 November 1963The Effect of Treatment in Patients with Chronic Myelogenous LeukemiaHematologic and Cytogenetic StudiesPAUL P. CARBONE, M.D., J. H. TJIO, M.D., JACQUELINE WHANG, M.D., JEROME B. BLOCK, M.D., WILLIAM B. KREMER, M.D., EMIL FREI III, M.D.PAUL P. CARBONE, M.D.Search for more papers by this author, J. H. TJIO, M.D.Search for more papers by this author, JACQUELINE WHANG, M.D.Search for more papers by this author, JEROME B. BLOCK, M.D.Search for more papers by this author, WILLIAM B. KREMER, M.D.Search for more papers by this author, EMIL FREI III, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-5-622 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChemotherapy or X irradiation produces improvement in the clinical and hematologic abnormalities in the majority of patients with chronic myelogenous leukemia (CML) (1-5). Return of the leukocyte alkaline phosphatase (LAP) and bone marrow morphology toward normal has been described but is less frequent (6-11). Recently, Tough and co-workers (12) have reported that the chromosome abnormality (Ph1) which is present in the majority of patients with CML disappears from the peripheral blood but not from the marrow after splenic X irradiation. The present study was designed to determine the relative frequency and magnitude of response of clinical, hematologic, and cytogenetic abnormalities...References1. RUNDLESGRIZZLEBELLCORLEYFROMMEYERGREENBERGHUGULEYJAMESJONESLARSENLOEBLEONEPALMERRISERWILSON RWJWNCCWBBGCMGWRWEVLAJGWHSJ: Comparison of chlorambucil and myleran in chronic lymphocytic and granulocytic leukemia. Amer. J. Med. 27: 424, 1959. CrossrefGoogle Scholar2. HAUTABBOTTWINTROBECARTWRIGHT AWSMMGE: Busulfan in the treatment of chronic myelocytic leukemia. The effect of long term intermittent therapy. Blood 17: 1, 1961. CrossrefMedlineGoogle Scholar3. REINHARDNEELYSAMPLES EHCLDM: Radioactive phosphorus in the treatment of chronic leukemias: Long term results over a period of 15 years. Ann. Intern. Med. 50: 942, 1959. LinkGoogle Scholar4. ELLISONBURCHENAL RRJH: Treatment of chronic granulocytic leukemia with the 6-substituted purines, 6-mercaptopurine, thioguanine and 6-chlorpurine. Clin. Pharmacol. Ther. 1: 631, 1960. MedlineGoogle Scholar5. OSGOODSEAMAN EEAJ: Treatment of chronic leukemias. Results of therapy by titrated, regularly spaced total body radioactive phosphorus or roentgen irradiation. JAMA 150: 1372, 1952. CrossrefMedlineGoogle Scholar6. HELBIGWEISSEL WM: Treatment of chronic myeloid leukemia with myleran (Myeleukon) with particular reference to the alkaline phosphatase activity of leukocytes. Munchen. Med. Wschr. 103, (48): 2390, 1961. MedlineGoogle Scholar7. KEMPHERNDONWRIGHT JAJWC: Vaccillations in leukocyte alkaline phosphatase. Southern Med. J. 55: 281, 1962. CrossrefMedlineGoogle Scholar8. BERLINLAWRENCE NIJH: The changes in the bone marrow differential in chronic leukemia treated with P32 and Y90. Acta Med. Scand. 140: 99, 1951. CrossrefMedlineGoogle Scholar9. HOTCHKISSBLOCK DJMH: Effect of splenic irradiation in systemic hematopoiesis. Arch Intern. Med. (Chicago) 109: 695, 1962. CrossrefMedlineGoogle Scholar10. MELLERGOTTLIEBBRAUNER OFR: The importance of indications from sternal puncture in roentgen therapy. Radiology 31: 149, 1938. CrossrefGoogle Scholar11. GUNZ FW: Bone marrow changes in patients with chronic leukemia treated by splenic x-irradiation. Blood 8: 687, 1953. CrossrefMedlineGoogle Scholar12. TOUGHCOURT-BROWNBAIKIEBUCKTONHARNDENJACOBSWILLIAMS IMWMAGKEDGPAJA: Chronic myeloid leukemia. Cytogenetic studies before and after splenic irradiation. Lancet 2: 115, 1962. CrossrefMedlineGoogle Scholar13. BLOCKCARBONEOPPENHEIMFREI JBPPJJE: The effects of treatment in patients with chronic myelogenous leukemia: biochemical studies. Ann. Intern. Med. 59: 5, 0000. Google Scholar14. WINTROBE MM: Clinical Hematology, 5th Edition, Lea & Febiger, Philadelphia, 1961. Google Scholar15. TJIOWHANG JHJ: Chromosome preparations of bone marrow cells without prior in vitro culture or in vivo colchicine administration. Stain Techn. 37: 17, 1962. CrossrefMedlineGoogle Scholar16. MOORHEADNOWELLMELLMANBATTIPSHUNGERFORD PSPCWJDMDA: Chromosome preparations of leukocytes cultured from human peripheral blood. Exp. Cell Res. 20: 613, 1960. CrossrefMedlineGoogle Scholar17. LEONARDWILKINSON BJJF: Deacetylmethylcolchicine in treatment of myeloid leukemia. Brit. Med. J. 1: 874, 1955. CrossrefMedlineGoogle Scholar18. MINOTBUCKMANISAACS GRTER: Chronic myelogenous leukemia: incidence, duration and benefit derived from irradiation. JAMA 82: 1489, 1924. CrossrefGoogle Scholar19. BURCHENALMURPHYTAN JHMLCT: Treatment of acute leukemia. Pediatrics 18: 643, 1956. MedlineGoogle Scholar20. KARONFREIREICHFREI MREJE: A preliminary report on vincristine sulfate: a new active agent for the treatment of acute leukemia. Pediatrics 30: 791, 1962. Google Scholar21. FREIFRANZINOSHNIDERCOSTACOLSKYBRINDLEYHOSLEYHOLLANDGOLDJONSSON EABIGJCOHJFGLV: Clinical studies of vinblastine. Cancer Chemother. Rep. 12: 125, 1961. MedlineGoogle Scholar22. FALLONFREIFREIREICH HJEEJ: Correlation of the biochemical and clinical effects of 6-azauridine in patients with leukemia. Amer. J. Med. 33: 526, 1962. CrossrefGoogle Scholar23. HUNGERFORD DA: Chromosome studies in human leukemia. I. Acute leukemia in children. J. Nat. Cancer Inst. 27: 983, 1961. MedlineGoogle Scholar24. HUNGERFORDNOWELL DAPC: Chromosome studies in human leukemia. III. Acute granulocytic leukemia. J. Nat. Cancer Inst. 29: 545, 1962. MedlineGoogle Scholar25. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. J. Nat. Cancer Inst. 27: 1013, 1961. MedlineGoogle Scholar26. SANDBERGTAKAAKICROSSWHITEHAUSCHKA AALLHTS: Comparison of chromosome constitution in chronic myelocytic leukemia and other myeloproliferative disorders. Blood 20: 393, 1962. CrossrefMedlineGoogle Scholar27. TOUGHCOURT-BROWNBAIKIEBUCKTONHARNDENJACOBSKINGMCBRIDE IMWMAGKEDGPAMJJA: Cytogenetic studies in chronic myeloid leukemia and acute leukemia associated with mongolism. Lancet 1: 411, 1961. CrossrefMedlineGoogle Scholar28. FITZGERALDADAMSGUNZ PHAFW: Chronic granulocytic leukemia and the Philadelphia chromosome. Blood 21: 183, 1963. CrossrefMedlineGoogle Scholar29. WHANGFREITJIOCARBONEBRECHER JEJHPPG: The distribution of Philadelphia chromosome (Ph1) in patients with chronic myelogenous leukemia. Blood. In Press. Google Scholar30. BUCKTONJACOBSCOURT-BROWNDOLL KEPAWMR: A study of the chromosome damage persisting after x-ray therapy for ankylosing spondylitis. Lancet 2: 676, 1962. CrossrefMedlineGoogle Scholar31. BIESELE JJ: Mitotic Poisons and the Cancer Problem. Elsevier Publishing Company, Amsterdam, 1958, p. 84. Google Scholar32. ELVESBUTTOOISRAELSWILKINSON MWASMCJF: Chromosome changes caused by 6-azauridine during treatment of acute myeloblastic leukaemia. Brit. Med. J. 1: 156, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland.Requests for reprints should be addressed to Paul P. Carbone, M.D., Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDie chronische myeloische LeukämieChromosomal Changes in Human Tumors and LeukemiasThe Spectrum of Myeloproliferative DisordersAnomalies of the Small Acrocentric (chromosomes in Human Tumour Cells*Granulopoiesis in Chronic Granulocytic LeukaemiaUnfavorable Signs in Patients with Chronic Myelocytic LeukemiaATHANASIOS THEOLOGIDES, M.D., Ph.D., F.A.C.P.Das Philadelphia ChromosomThe myeloproliferative disordersBusulfanSPECIFICITY OF THE Ph1 CHROMOSOMEPh1 PREVALENCE, PERIPHERAL BLOOD PICTURE AND CYTOSTATIC THERAPYCYTOGENETIC STUDIES IN CHRONIC GRANULOCYTIC LEUKAEMIAChromosomenuntersuchungen bei chronisch-myeloischer LeukämieProgress in treatment for the leukemias and lymphomasComparison of Philadelphia Chromosome-Positive and -Negative Patients with Chronic Myelocytic LeukemiaSTEPHEN KRAUSS, M.D., JOSEPH E. SOKAL, M.D., AVERY A. SANDBERG, M.D.TWO CASES OF CHRONIC MYELOID LEUKAEMIA WITH PRESUMABLY IDENTICAL 47-CHROMOSOME CELL-LINES IN THE BLOODSeveral Cell-Lines with Abnormal Karyotypes in a Patient with Chronic Myelogenous Leukaemia 1 November 1963Volume 59, Issue 5_Part_1Page: 622-628KeywordsBone marrowCancer treatmentChemotherapyChromosomesChronic myelocytic leukemiaChronic myelogenous leukemiaCytogeneticsPatientsPhosphatasesX chromosomes Issue Published: 1 November 1963 PDF DownloadLoading ...