tbuckley/cabot-search huggingface dataset:
The Acquired Immunodeficiency Syndrome and Female Sexual Partners of Bisexual Men
Authors: COLIN L. SOSKOLNE
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 February 1984The Acquired Immunodeficiency Syndrome and Female Sexual Partners of Bisexual MenCOLIN L. SOSKOLNE, PH.D.COLIN L. SOSKOLNE, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-2-312_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Metroka and associates (1) have reported a syndrome resembling the acquired immunodeficiency syndrome among wives of bisexual men who do not use intravenous drugs, do not have hemophilia, and are not Haitian (1) and suggest these cases are evidence for expanding the groups at increased risk for the syndrome. Although their results may support the hypothesis of transmission by a specific agent resulting in a spectrum of outcomes, caution is suggested before expanding the groups at risk to the wives or the female sexual partners of bisexual men.In identifying groups at increased risk for the syndrome,...References1. METROKAMOURADIANCUNNINGHAM-RUNDLES CJS. The acquired immunodeficiency syndrome [Letter]. Ann Intern Med. 1983;99:734. LinkGoogle Scholar2. . Update: Acquired immunodeficiency syndrome (AIDS)—United States. MMWR. 1983;32:465-7. MedlineGoogle Scholar3. DETELSSCHWARTZVISSCHER RKB. Relation between sexual practices and T-cell subsets in homosexually active men. Lancet. 1983;1:609-11. CrossrefMedlineGoogle Scholar4. JAFFECHOITHOMAS HKP. National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: part 1, epidemiologic results. Ann Intern Med. 1983;99:145-51. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: COLIN L. SOSKOLNE, PH.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1984Volume 100, Issue 2Page: 312-312KeywordsAIDSBisexualsDrugsHemophiliaRisk management ePublished: 1 December 2008 Issue Published: 1 February 1984 PDF downloadLoading ...
Topical intranasal corticosteroids for otitis media with effusion in primary care
Authors: R. A M J Damoiseaux, M. M Rovers
Journal: BMJ (2010)

Are ineffective, and active observation is the best policy

Otitis media with effusion refers to an accumulation of fluid in the middle ear cavity behind an intact tympanic membrane with no signs or symptoms of an acute infection. It is one of the most common diseases of childhood. The condition can cause conductive hearing loss, which can result in impairments of speech, language, and cognitive development.1 The effusion often resolves spontaneously within three months, and this needs to be taken into account when managing the condition.

In the linked randomised controlled trial (doi:10.1136/bmj.b4984), Williamson and colleagues assessed the effectiveness of topical intranasal corticosteroids compared with placebo in 217 children with bilateral otitis media with effusion. They found no significant difference between the two groups at one or three months.2 

Recent guidance from the National Institute for Health and Clinical Excellence (NICE) recommends active observation for three months before intervention is considered.3 …
P06.05 * A CASE OF RADIATION-INDUCED MENINGIOMAS
Authors: A. Innocenti, G. Simonetti, P. Gaviani, A. Botturi, E. Lamperti, L. Fariselli, A. Silvani
Journal: Neuro-Oncology (2014)

Meningiomas are known to be induced by low and high-dose radiotherapy and several studies suggest an inverse relationship between dose administered and time of tumor development. Radiation-induced meningiomas have been usually reported to be histologically atypical, multiple, associated with a poor clinical outcome. We report a case of a young woman operated upon in 1990 at the age of 18 years old for ependymoma in the 4th ventricle. Three years later a local recurrence was detected, and a chemotherapy was began. During follow-up, MRI revealed a meningeal dissemination and the patient was treated with whole brain radiotherapy and intrathecal chemotherapy. She was radiologically stable for 10 years, then she presented another new mass, an acoustic neurinoma, treated with radiosurgery. In August 2010 the patient complained headache which gradually increases over the preceding weeks. A new MRI revealed the presence of multiple meningeal nodules, rapidly growing in a couple of months. The largest one (30 mm diameter) grew from the falx, in right parieto-occipital lobe; this mass was isointense in T1-weighted images, with a definite uptake of contrast enhancement. Histopathological examination showed a transitional meningioma with dural infiltration consistent with radiation-induced meningiomas. Lesions remained unchanged for several months, and, despite of number of nodules, the patient was almost asymptomatic. In our case report, many evidences, such as the younger age, the radiotherapy treatment and the latency interval between radiotherapy and lesions finding, suggest that the multiple meningeal nodules were radiation-induced meningiomas. The lack of information about the clinical and biological features of radiation-induced meningiomas does not actually allow to understand the clinical behavior of these lesions. Considering the increasing number of patients treated with radiotherapy, we believe it is essential to understand which patient features are linked to the development of radiation-induced meningiomas, in order to identify a subset of patients with higher risk.
Noninvasive determination of the mitral valve area in stenosis: a computational model and correlation with autopsy and open heart measurements
Authors: W S SEITZ, E J OPERSCHALL
Journal: Cardiovascular Research (1980)

An analytical formulation has been developed which allows the computation of mitral valve area (A) from the potentially noninvasive paramaeters of hear rate (R), cardiac output (CO) and diastolic filling period (DFP) by the equation A = 21 CO/R x DFP2. The computed areas correlate with autopsy and open heart measurements (r = 0.91) for resting state conditions of moderate to severe mitral stenosis. These results suggest that noninvaasive methods can have an application in mitral valve determinations.
Synovial amyloid deposits and chronic haemodialysis
Authors: I. F. Rowe
Journal: Annals of the Rheumatic Diseases (1986)

Synovial amyloid deposits and chronic haemodialysis SIR, In their recent paper Mufioz-Gomez et al' suggested that localised synovial amyloidosis might be peculiar to chronic renal failure treated with periodical haemodialysis, and they made the assumption that it was the cause of an arthropathy.In fact localised amyloid deposition in synovium and also in articular cartilage is a common aging phenomenon2 apparently associated with osteoarthrosis, and it is relevant that four of the seven patients studied were aged 50 years or more.This type of aging deposit was actually referred to in the preceding editorial as 'joint capsule and articular cartilage' deposition.]The nature and extent of synovial amyloid deposits described in the article did not appear to differ from those associated with aging, and I would suggest that the finding of such deposits may represent no more than an accelerated age change.It is of interest in this context that synovial and articular cartilage amyloid deposits in patients with the so called amyloid arthropathy syndrome of multiple myeloma and primary amyloidosis do not appear to differ qualitatively from aging deposits either.4Such patients may, however, show gross soft tissue amyloid deposition around joints.The finding of synovial amyloid deposits in chronic haemodialysis patients may be unrelated to any arthropathy present and should not prevent other causes for an arthropathy from being sought.
Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats.
Authors: H A Kontos, E P Wei, J T Povlishock, C W Christman
Journal: Circulation Research (1984)

Topical application of sodium arachidonate (50-200 micrograms/ml) or bradykinin (0.1-10 micrograms/ml) on the brain surface of anesthetized cats caused dose-dependent cerebral arteriolar dilation. This dilation was blocked by 67-100% in the presence of superoxide dismutase and catalase. These enzymes did not affect the changes in arteriolar diameter caused by alterations in arterial blood PCO2, or the arteriolar dilation from topical acetylcholine. Enzymes inactivated by heat had no effect on the vasodilation from arachidonate or bradykinin. Superoxide dismutase alone or catalase alone reduced the dilation during application of 200 micrograms/ml of arachidonate for 15 minutes; they also completely prevented the residual dilation seen 1 hour after washout, as well as the reduction in the vasoconstrictive effects of arterial hypocapnia observed at this time. The results show that superoxide anion radical and hydrogen peroxide, or radicals derived from them, such as the hydroxyl radical, are mediators of the cerebral arteriolar dilation from sodium arachidonate or bradykinin. These radicals are not the endothelium-derived relaxant factor released by acetylcholine. The presence of both superoxide anion radical and hydrogen peroxide is required for the production of the vascular damage seen during prolonged application of high concentrations of sodium arachidonate.
Immunofluorescence findings in pityriasis lichenoides
Authors: C. Nieboer, G.L. Kalsbeek
Journal: British Journal of Dermatology (1980)

Journal Article Immunofluorescence findings in pityriasis lichenoides Get access C. Nieboer, C. Nieboer Department of Dermatology, Academic Hospital, Free University, de Boelaan 1117, Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar G.L. Kalsbeek G.L. Kalsbeek Department of Dermatology, Academic Hospital, Free University, de Boelaan 1117, Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 103, Issue 1, 1 July 1980, Pages 120–121, https://doi.org/10.1111/j.1365-2133.1980.tb15854.x Published: 01 July 1980
The interaction of Concanavalin A and the surface coat of stratified squamous epithelium
Authors: J.M.J. LIS, G.L. KALSBEEK
Journal: British Journal of Dermatology (2006)

The interaction of Concanavalin A (Con A) and the surface membranes of the epithelial cells of human oral mucosa, epidermis and guinea-pig lip was studied. Two methods were used: fluorescent Con A and Con A in combination with horse radish peroxidase. With both methods the surface coat of epithelial cells was stained. The specificity of the staining methods could be demonstrated. The interaction between pemphigus antibodies and the surface membranes of epithelial cells could be blocked by Con A.
Effects of combination of sibutramine and l-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients
Authors: Giuseppe Derosa, Pamela Maffioli, Sibilla A.T. Salvadeo, Ilaria Ferrari, Alessia Gravina, Roberto Mereu, Angela D'Angelo, Ilaria Palumbo, Sabrina Randazzo, Arrigo F.G. Cicero
Journal: Metabolism (2010)
Release and Capture of Bioactive Oxidized Phospholipids and Oxidized Cholesteryl Esters During Percutaneous Coronary and Peripheral Arterial Interventions in Humans
Authors: Amir Ravandi, Gregor Leibundgut, Ming-Yow Hung, Mitul Patel, Patrick M. Hutchins, Robert C. Murphy, Anand Prasad, Ehtisham Mahmud, Yury I. Miller, Edward A. Dennis, Joseph L. Witztum, Sotirios Tsimikas
Journal: Journal of the American College of Cardiology (2014)
The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells
Authors: Sebastian Drube, Sylvia Heink, Sabine Walter, Tobias Löhn, Mandy Grusser, Alexander Gerbaulet, Luciana Berod, Julia Schons, Anne Dudeck, Jenny Freitag, Stefan Grotha, Daniela Reich, Olga Rudeschko, Johannes Norgauer, Karin Hartmann, Axel Roers, Thomas Kamradt
Journal: Blood (2010)
Misleading chest x-ray film in psoriasis.
Authors: G A Price
Journal: BMJ (1976)

only in this position and even slept in this manner.This was not an individual habit and had not been present before the onset of this illness.The only other physical signs were in the abdomen, where there was slight general distension and a characteristic tumour palpable in the left iliac fossa.Rectal examination was normal.Laparotomy was performed that evening, and an easily reducible caecocolic intussusception was found, which, owing to partial spontaneous reduction, was in the left hypochondrium.Numerous enlarged lymph nodes were found in the mesentery, and histological examination of one of these showed reactive hyperplasia.The child made an uneventful recovery.The position adopted by this child clearly relieved his pain, and in view of the anatomy in this particular case it would seem likely that the child was unconsciously using gravity in an attempt to reduce the intussusception.This sign does not feature in textbooks and is obviously unusual.It was not encountered in any of 67 cases described in clinical detail by Kark and Rundle.'However, although unusual, the sign is a dramatic one and should alert one -to the diagnosis at a glance if its significance is appreciated.
Kinetics and Epigenetics of Retroviral Silencing in Mouse Embryonic Stem Cells Defined by Deletion of the D4Z4 Element
Authors: Sylvie Rival-Gervier, Mandy YM Lo, Shahryar Khattak, Peter Pasceri, Matthew C Lorincz, James Ellis
Journal: Molecular Therapy (2013)

Retroviral vectors are silenced in embryonic stem (ES) cells by epigenetic mechanisms whose kinetics are poorly understood. We show here that a 3'D4Z4 insulator directs retroviral expression with persistent but variable expression for up to 5 months. Combining an internal 3'D4Z4 with HS4 insulators in the long terminal repeats (LTRs) shows that these elements cooperate, and defines the first retroviral vector that fully escapes long-term silencing. Using FLP recombinase to induce deletion of 3'D4Z4 from the provirus in ES cell clones, we established retroviral silencing at many but not all integration sites. This finding shows that 3'D4Z4 does not target retrovirus integration into favorable epigenomic domains but rather protects the transgene from silencing. Chromatin analyses demonstrate that 3'D4Z4 blocks the spread of heterochromatin marks including DNA methylation and repressive histone modifications such as H3K9 methylation. In addition, our deletion system reveals three distinct kinetic classes of silencing (rapid, gradual or not silenced), in which multiple epigenetic pathways participate in silencing at different integration sites. We conclude that vectors with both 3'D4Z4 and HS4 insulator elements fully block silencing, and may have unprecedented utility for gene transfer applications that require long-term gene expression in pluripotent stem (PS) cells.
The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes: experiments with living leukocytes.
Authors: J Blondin, A Janoff
Journal: Journal of Clinical Investigation (1976)

Human polymorphonuclear leukocyte (PMN) elastase has been implicated in various pathological conditions. However, its physiological role remains undefined. One possible function of this enzyme may be digestion of bacterial proteins after phagocytosis. To test this hypothesis, we prepared Escherichia coli labeled with [3H]arginine and treated these bacteria with a lipid-soluble, active-site-directed chloromethyl ketone inactivator of pancreatic and granulocyte elastases (carbobenzoxy-L-glycyl-L-leucyl-L-alanine chloromethyl ketone, dissolved in methanol). Control bacteria were treated with methanol alone. When E. coli pretreated with the inactivator were incubated with solutions of porcine pancreatic elastase or with PMN granule extract, release of trichloroacetic acid-soluble radioactivity was significantly lower than in the control E. coli. Similar results were obtained when treated and control E. coli were fed to viable human PMN. In contrast, release of trichloroacetic acid-soluble radioactivity from E. coli containing [3H]thymidine was not affected by pretreatment of bacteria with elastase inactivator before feeding them to PMN, suggesting that phagocytosis of E. coli had not been inhibited by the chloromethyl ketone. When treated and control bacteria were fed to PMN, no significant difference was observed in the activity of lysosomal beta-glucuronidase recovered from post-granule supernatant fractions of homogenized leukocytes, suggesting that lysosomal degranulation had not been suppressed by the inactivator. However, elastase activity of the same fractions was depressed if the leukocytes had phagocytized chloromethyl ketone-treated E. coli, suggesting that inhibition of PMN elastase had occurred. We conclude that PMN elastase participates in digestion of E. coli proteins by human PMN.
Prognostic Role of the Reduced Folate Carrier, the Major Membrane Transporter for Methotrexate, in Childhood Acute Lymphoblastic Leukemia: A Report from the Children's Oncology Group
Authors: Yubin Ge, Christina L. Haska, Katherine LaFiura, Meenakshi Devidas, Stephen B. Linda, Mingjun Liu, Ronald Thomas, Jeffrey W. Taub, Larry H. Matherly
Journal: Clinical Cancer Research (2007)

Abstract Purpose: The value of measuring expression of individual genes relevant to particular chemotherapy drugs and encoding metabolizing enzymes, transporters, or drug targets, as predictors of treatment response and outcome in pediatric acute lymphoblastic leukemia (ALL), remains controversial. Experimental Design: In a case-control population of 91 pediatric B-precursor ALL patients [42 relapsed within 4 years (cases) and 49 did not relapse (controls)], we used real-time reverse transcription-PCR to measure transcript levels for 20 genes relevant to chemotherapy with the five major drugs used to treat this disease, including asparaginase, 6-mercaptopurine, methotrexate, prednisone, and vincristine. Results were confirmed in a separate case-control population of 26 patients. Results: Only the human reduced folate carrier (hRFC) gene, encoding the major membrane transporter for methotrexate, showed a significant difference in median transcript levels between the 42 cases and the 49 controls (P = 0.0278, Wilcoxon test). Using cutoffs for hRFC expression levels (based on Akaike information criterion), there were statistically significant associations between hRFC transcripts and treatment relapse (P = 0.0052). hRFC-B, corresponding to the major hRFC transcript form in ALL, was also measured by real-time reverse transcription-PCR and was prognostic. The association between treatment relapse and hRFC levels was validated in a separate study population of 14 cases and 12 controls from an earlier case-control study (P = 0.0221). Conclusions: Our results strongly suggest the prognostic importance of hRFC gene expression to treatment outcomes in pediatric ALL. They validate our previous studies of hRFC transcriptional regulation in pediatric ALL and provide further compelling evidence for the critical role for methotrexate in the successful treatment of this disease.
An Outbreak of Nitrogen Dioxide—Induced Respiratory Illness Among Ice Hockey Players
Authors: Katrina Hedberg
Journal: JAMA (1989)

During February 1987 an outbreak of nitrogen dioxide—induced respiratory illness occurred among players and spectators of two high school hockey games played at an indoor ice arena in Minnesota. The source of the nitrogen dioxide was the malfunctioning engine of the ice resurfacer. Case patients experienced acute onset of cough, hemoptysis, and/or dyspnea during, or within 48 hours of attending, a hockey game. One hundred sixteen cases were identified among hockey players, cheerleaders, and band members who attended the two games. Members of two hockey teams had spirometry performed at 10 days and 2 months after exposure; no significant compromise in lung function was documented. Nitrogen dioxide exposure in indoor ice arenas may be more common than currently is recognized; only three states require routine monitoring of air quality in ice arenas, and the respiratory symptoms caused by exposure to nitrogen dioxide are nonspecific and easily misdiagnosed. (<i>JAMA</i>. 1989;262:3014-3017)
Nucleoprotein changes in the hearts of cardiomyopathic turkeys
Authors: C. J LIMAS, S. EINZIG, G. R NOREN
Journal: Cardiovascular Research (1982)

The possible involvement of nuclear proteins in the pathogenesis of a spontaneously occurring model of congestive cardiomyopathy in turkeys was examined. This model is characterised by cardiac hypertrophy and dilatation, reduced cardiac output and depressed contractility. The protein composition of myocardial nuclei was compared in normal (n=9) and cardiomyopathic (n=18) turkeys, 70 to 140 days old. Myopathic hearts as a group have a higher histone content (1.75±0.09 (SD) mg·mg DNA−1vs 1.65±0.07 in controls, P<0.01) and histone/nonhistone protein (NHP) ratio (1.07±0.07 vs 0.95±0.02 in controls, P<0.01). The latter was independent of age and correlated well with the degree of cardiac dilatation. The electrophoretic patterns of chromatin proteins did not differ in the two experimental groups. In vitro phosphorylation of nuclear proteins was decreased in myopathic hearts. This decrease was primarily accounted for by lower NHP phosphorylation (5.78 ± 1.38 pmol 32P·mg prot−1·15 min−1vs 8.33±0.81 in controls, P<0.0l). DEAE-Sephacel chromatography separated cyclic AMP-dependent and -independent nuclear protein kinases with similar substrate specificities but lower specific activities in myopathic hearts. SDS-polyacrylamide gel electrophoresis of phosphorylated nucleoproteins revealed differences in the lower molecular species of NHPs between control and myopathic hearts. There was a significant correlation between NHP phosphorylation and degree of cardiac dilatation (r = −0.78) or contractility as reflected by left ventricular systolic time intervals (r = −0.57). These results suggest that development of this model of spontaneous cardiomyopathy is associated with, and may, in part, be secondary to changes in the composition and function of myocardial nucleoproteins.
GW25-e1585 Association of nicotinamide phosphoribosyltransferase (NAMPT) gene polymorphisms and of NAMPT expression with Dilated cardiomyopathy in a Chinese population
Authors: Dou Qingyu, Ying Peng, Bin Zhou, Kui Zhang, Jing Lin, Yajiao Li, Hao Yang, Qiu Xie, Chunmei Li, Li Rao
Journal: Journal of the American College of Cardiology (2014)
Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations
Authors: Ellen Leich, Itziar Salaverria, Silvia Bea, Andreas Zettl, George Wright, Victor Moreno, Randy D. Gascoyne, Wing-Chung Chan, Rita M. Braziel, Lisa M. Rimsza, Dennis D. Weisenburger, Jan Delabie, Elaine S. Jaffe, Andrew Lister, Jude Fitzgibbon, Louis M. Staudt, Elena M. Hartmann, Hans-Konrad Mueller-Hermelink, Elias Campo, German Ott, Andreas Rosenwald
Journal: Blood (2009)
Job cuts look likely as NHS faces final year of real growth before spending freeze
Authors: R. Coombes
Journal: BMJ (2010)

The NHS is set to face a round of job losses as organisations confront the difficult economic situation.

Although ringfenced from the brutal public spending cuts expected in other public services, the NHS has been warned to expect zero growth in funding over the next six years.

Cambridge University Hospitals NHS Foundation Trust, which runs Addenbrooke’s Hospital, recently invited staff to apply for a voluntary severance scheme. The BMJ also understands that several London trusts will launch voluntary redundancy or severance programmes over the next few months.

Speaking at a financial seminar in London last week, Chris Ham, chief executive of the healthcare think tank the King’s Fund, said that although the NHS would be relatively protected it would still need to make up to £20bn (€24bn; $30bn) in efficiency cuts. “In large hospitals 70% of spending is on pay, …