Marine Omega-3 Fatty Acids and Atherosclerosis
Authors: JOSHUA LYNFIELD
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 March 1988Marine Omega-3 Fatty Acids and AtherosclerosisJOSHUA LYNFIELD, M.D.JOSHUA LYNFIELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-3-483 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by von Schacky (1) is welcome as there is widespread and perhaps uncritical enthusiasm for the prescription of marine omega-3 fatty acids for prophylaxis of atherosclerosis in humans. Human studies on fish consumption (2) and animal studies supporting the use of omega-3 fatty acids for prevention of atherosclerosis have largely focused their attention on the coronary arteries (3). However, the issue is more complex, and although coronary atherosclerosis may be favorably affected by consumption of omega-3 fatty acids, recent animal data (4) suggest that atherosclerotic changes at the carotid bifurcation are significantly greater in animals...References1. VON SCHACKY C. Prophylaxis of atherosclerosis with marine omega-3 fatty acids: a comprehensive strategy. Ann Intern Med. 1987;107:890-9. LinkGoogle Scholar2. KROMHOUTBOSSCHIETERCOULANDER DEC. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med. 1985;312:1205-9. CrossrefMedlineGoogle Scholar3. WEINEROCKENELEVINE BIP. Inhibition of atherosclerosis by cod liver oil in a hyperlipidemic swine model. N Engl J Med. 1986;315:841-6. CrossrefMedlineGoogle Scholar4. KROMANNGREEN NA. Epidemiological studies in the Upernavik district, Greenland. Acta Med Scand. 1980;208:401-6. CrossrefMedlineGoogle Scholar5. HOLLANDERHONGKIRKPATRICKLEECOLOMBOPRUSTY WSBAMS. Differential effects of fish oil supplements on atherosclerosis. Circulation. 1987;76(Supp IV):313. Google Scholar1. VON SCHACKY C. Prophylaxis of atherosclerosis with marine omega-3 fatty acids: a comprehensive strategy. Ann Intern Med. 1987;107:890-9. LinkGoogle Scholar2. LAVIESQUIRESGAU CRG. Preventive cardiology: what is the role of fish and fish oils in primary and secondary prevention? J Cardiopulmonary Rehabil. 1987;7:526-33. CrossrefGoogle Scholar3. SANDERSNAISMITHHAINESVICKERS TDAM. Cod-liver oil, platelet fatty acids, and bleeding time [Letter]. Lancet. 1980;1:1189. CrossrefMedlineGoogle Scholar4. THOMPSON G. Lipids, fish, and coronary heart disease. Current Opinion in Cardiology. 1986;1:827-31. CrossrefGoogle Scholar5. ROGANS J. More on fish oils [Letter]. N Engl J Med. 1987;316:626-7. Google Scholar1. VON SCHACKY C. Prophylaxis of atherosclerosis with marine omega-3 fatty acids: a comprehensive strategy. Ann Intern Med. 1987;107:890-9. LinkGoogle Scholar2. FOXHAY JR. Inhibition of triglyceride secretion by ω-3 polyunsaturated fatty acid in cultured rat hepatoma cells [Abstract]. Circulation. 1987;76(Supp):IV-40. Google Scholar3. HEROLDKINSELLA PJ. Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animals and human feeding trials. Am J Clin Nutr. 1986;43:566-98. CrossrefMedlineGoogle Scholar4. ROACHKAMBOURISTRIMBLETOPPINGNESTEL PARDP. Fish oil down-regulates the low density lipoprotein receptor and up-regulates the high density lipoprotein receptor of rat liver [Abstract]. Circulation. 1987;76(Supp):IV-325. Google Scholar5. HARRISDUJOVNEZUCKERJOHNSON WCMB. Fish oil supplements raise low density lipoprotein cholesterol levels in hypertriglyceridemic patients [Abstract]. Circulation. 1987;76(Supp):IV-168. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDietary prevention of coronary artery disease 1 March 1988Volume 108, Issue 3Page: 483-485KeywordsArmed forcesAtherosclerosisCoronary arteriesFatty acidsProphylaxisStable coronary artery disease Issue Published: 1 March 1988 PDF DownloadLoading ...