tbuckley/cabot-search huggingface dataset:
872 Tumor necrosis factor (TNF)-alfa mediated apoptosis in anti-tubercular drug induced hepatotoxicity
Authors: A CHOWDHURY
Journal: Hepatology (2003)

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane cytokine molecule of TNF family and a potent inducer of apoptosis. The anticancer activities of TNF family members are often modulated by interferon (IFN)-γ. Thus, we investigated whether IFN-γ enhances TRAIL-induced apoptosis. We exposed HeLa cells to IFN-γ for 12 h and then treated with recombinant TRAIL protein. No apoptosis was induced in cells pretreated with IFN-γ, and TRAIL induced 25% cell death after 3 h treatment. In HeLa cells pretreated with IFN-γ, TRAIL induced cell death to more than 70% at 3 h, indicating that IFN-γ pretreatment sensitized HeLa cells to TRAIL-induced apoptosis. We investigated molecules that might be regulated by IFN-γ pretreatment that would affect TRAIL-induced apoptosis. Western blotting analyses demonstrated that TRAIL treatment increased the level of IAP-2 protein and IFN-γ pretreatment inhibited the upregulation of IAP-2 protein by TRAIL protein. Our data indicate that TRAIL can signal to activate both apoptosis induction and antiapoptotic mechanism, at least, through IAP-2 simultaneously. IFN-γ or TRAIL treatment alone did not change expression of other pro- or antiapoptotic proteins such as DR4, DR5, FADD, Bax, IAP-1, XIAP, Bcl-2, and Bcl-XL. Our findings suggest that IFN-γ may sensitize HeLa cells to TRAIL-induced apoptosis by preventing TRAIL-induced IAP-2 upregulation, and IFN-γ may play a role in anticancer therapy of TRAIL protein through such mechanism.
Propranolol and Epinephrine
Authors: Mary Linda Stotter
Journal: JAMA (1981)

<h3>To the Editor.—</h3> I found interesting the comprehensive discussions by Martin D. Valentine, MD, and David M. Kornhauser, MD, concerning the modification of the anaphylactic response by propranolol (1981;245:1767). I would like to add to the discussion the possibility of a drug interaction between epinephrine and propranolol.<sup>1,2</sup>This combination has led to bradycardia and arteriovenous block. By blocking the β receptors, propranolol allows unopposed a stimulation by epinephrine. Bradycardia probably results from a vagal reflex to the resulting hypertension. This possibility must be considered if epinephrine is administered to a patient receiving a β-blocker.
A Case Showing Complete Insulin Independence After Severe Diabetic Ketoacidosis Associated With Tacrolimus Treatment
Authors: Young Min Cho, Kyong Soo Park, Hye Seung Jung, Yon Su Kim, Seong Yeon Kim, Hong Kyu Lee
Journal: Diabetes Care (2002)

Post-transplant diabetes mellitus (PTDM) is a major metabolic complication after kidney transplantation (1). Diabetogenic potential of tacrolimus is known to be much higher than that of cyclosporine in the early post-transplantation period (2). Tacrolimus may cause PTDM by transcriptional inhibition of the insulin gene in the β-cell, which is known to be potentially reversible (3). We report a renal allograft recipient showing complete insulin independence after severe diabetic ketoacidosis associated with tacrolimus treatment.

A 35-year-old woman was admitted to the hospital via emergency room because of altered mentality. Six months before admission, she had undergone kidney transplantation for end-stage renal failure, the underlying cause of which was unknown. Immunosuppressive …
The World Bank and world health: Interview with Richard Feachem
Authors: K. Abbasi
Journal: BMJ (1999)

This is the last in a series of six articles examining the World Bank's role in international health

Dr Richard Feachem was director of health, nutrition, and population at the World Bank from 1995 until earlier this year. On 1 April 1999, he moved to become director of the new institute for global health at the University of California in San Francisco and in Berkeley. He retains the position of special adviser in health, nutrition, and population to the World Bank.



Richard Feacham



When I visited the bank's headquarters in Washington it was readily apparent that employees in the health sector strongly identified Dr Feachem with the bank's current policy direction. I spoke with him in May 1998; what follows is an edited transcript of that interview. I've excluded the times we were interrupted by ministers of health from Africa and by Bill Gates—senior.

Kamran Abbasi: When did your involvement with the World Bank begin?

Richard Feachem: My association with the World Bank goes back to 1975. I had a close interaction with the bank on a variety of health issues, starting with the health impact of water and sanitation. In 1988-9 I spent a year in Washington as a principal public health specialist, then returned to London to be dean of the London School of Hygiene and Tropical Medicine from 1989-95. In 1995 I moved back to the bank to become director of health, nutrition, and population. In 1992-3 I chaired the advisory committee for the 1993 World Development Report, which was a significant milestone in the bank's work on health policy.

“The bank has tremendous influence, which is a danger, but also rewarding.”

KA: For much of that time, the bank has been heavily criticised. Why did you get involved with it?

RF: The bank is a very …
Review: Intensive blood pressure control reduces stroke, but not mortality or MI, in type 2 diabetes
Authors: Louise Moist
Journal: Annals of Internal Medicine (2013)

Source Citation McBrien K, Rabi DM, Campbell N, et al. Intensive and standard blood pressure targets in patients with type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med. 2012;172:1296-303. 22868819
Fatal Myocardial Infarction in Marathon Racing
Authors: LAURENCE H. GREEN
Journal: Annals of Internal Medicine (1976)

A 44-year-old trained marathon runner collapsed after completing 24 miles of the 1973 Boston Marathon. He was resuscitated from ventricular fibrillation. Death occurred after 50 days of coma. Extensive transmural anterior myocardial infarction was documented on electrocardiogram and proved at autopsy, yet the coronary arteries were free of significant atherosclerosis. We believe this report to be the first documentation of a myocardial infarction in a trained athlete while participating in a marathon. We emphasize that the relation between exertion and infarction is unknown. Advocates of long distance running for prevention of, or rehabilitation from, ischemic heart disease should be aware of this possible complication.
Rosette‐formation with mouse erythrocytes: VI. T, B, and third population lymphoid cells in mycosis fungoides and effect of leukopheresis
Authors: Sudhir Gupta, Bijan Safai, Robert A. Good
Journal: American Journal of Hematology (1978)

Abstract Peripheral blood from 16 patients with mycosis fungoides and two patients with Sézary syndrome was examined for T, B, and third‐population (K) cells, using a battery of surface markers. T lymphocytes as determined by spontaneous rosette formation with sheep erythrocytes and third‐population cells as determined by the Ripley rosette test were present in normal proportions. Surprisingly, B lymphocytes, as determined by surface immunoglobulin and receptors for mouse erythrocytes, were either lacking or were present in low proportions in some patients. Normal proportions were present in others. Repeat studies of two of three patients lacking B lymphocytes, following treatment, revealed normal or low proportions of B cells. Two patients with mycosis fungoides had increased proportions of “null” cells. Study of lymphoid cell subpopulations before and after leukopheresis in a single patient demonstrated a decrease in T cell proportions associated with a concomitant increase in the proportions of “null” cells following this therapy.
Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Emi Tokuda, Toshiki Itoh, Junya Hasegawa, Takeshi Ijuin, Yukiko Takeuchi, Yasuhiro Irino, Miki Fukumoto, Tadaomi Takenawa
Journal: Cancer Research (2014)

Downregulation of cell-cell adhesion and upregulation of cell migration play critical roles in the conversion of benign tumors to aggressive invasive cancers. In this study, we show that changes in cell-cell adhesion and cancer cell migration/invasion capacity depend on the level of phosphatidylinositol 4-phosphate [PI(4)P] in the Golgi apparatus in breast cancer cells. Attenuating SAC1, a PI(4)P phosphatase localized in the Golgi apparatus, resulted in decreased cell-cell adhesion and increased cell migration in weakly invasive cells. In contrast, silencing phosphatidylinositol 4-kinase IIIβ, which generates PI(4)P in the Golgi apparatus, increased cell-cell adhesion and decreased invasion in highly invasive cells. Furthermore, a PI(4)P effector, Golgi phosphoprotein 3, was found to be involved in the generation of these phenotypes in a manner that depends on its PI(4)P-binding ability. Our results provide a new model for breast cancer cell progression in which progression is controlled by PI(4)P levels in the Golgi apparatus.
The β3-adrenergic receptor Trp64Arg mutation is not associated with coronary artery disease
Authors: Karl Stangl, Ingolf Cascorbi, Michael Laule, Verena Stangl, Christian Meisel, Klaus-Dieter Wernecke, Sabine Ziemer, Gert Baumann, Ivar Roots, Hans Hauner
Journal: Metabolism (2001)
Activation of nuclear factor-kappaB and not activator protein-1 in cellular response to nickel compounds.
Authors: Yi Huang, Gerard Davidson, Jingxia Li, Yan Yan, Fei Chen, Max Costa, Lung Chi Chen, Chuanshu Huang
Journal: Environmental Health Perspectives (2002)

The predominant exposure route for nickel compounds is by inhalation, and several studies have indicated the correlation between nickel exposure and respiratory cancers. The tumor-promoting effects of nickel compounds are thought to be associated with their transactivation of transcription factors. We have investigated the possible activation of activator protein-1 (AP-1) and nuclear factor KB (NF-kappaB) in mouse C141 epidermal cells and fibroblasts 3T3 and B82, and human bronchoepithelial BEAS-2B cells in response to nickel compound exposure. Our results show that NF-kappaB activity is induced by nickel exposure in 3T3 and BEAS-2B cells. Conversely, similar nickel treatment of these cells did not induce AP-1 activity, suggesting that nickel tumorigenesis occurs through NF-kappaB and not AP-1. We also investigated the role of NF-kappaB in the induction of Cap43 by nickel compounds using dominant negative mutant Ikappabeta kinase b-KM BEAS-2B transfectants.
THE EFFECTS OF AGING, SEX AND AEROBIC FITNESS ON MYOCARDIAL LIPID CONTENT
Authors: Satyam Sarma, Graeme Carrick-Ranson, Naoki Fujimoto, Paul Bhella, Jeffrey Hastings, Keri Shafer, Kara Boyd, Dean Palmer, Edward W. Szczepaniak, Lidia S. Szczepaniak, Benjamin Levine
Journal: Journal of the American College of Cardiology (2013)
Nonuniform course of left ventricular pressure fall and its regulation by load and contractile state.
Authors: A F Leite-Moreira, T C Gillebert
Journal: Circulation (1994)

BACKGROUND Effects of systolic left ventricular pressure (LVP) on rates of pressure fall remain incompletely understood. This study analyzed phase-plane dP/dt versus LVP plots to differentiate between accelerating and decelerating effects and to investigate the variability in reported load effects on rates of LVP fall. METHODS AND RESULTS Abrupt aortic occlusions were performed by inflating a balloon positioned in the ascending aorta of anesthetized open-chest dogs (n = 17). The occlusions resulted in clamp elevations of systolic LVP. In protocol A, the elevations of systolic LVP induced by total aortic occlusions were timed at early, mid, and late ejection. The magnitude of the elevations was 36.0 +/- 3.6 mm Hg for early, 11.6 +/- 0.6 mm Hg for mid, and negligible for late occlusions. The course of LVP fall appeared to be more complex than previously appreciated. Pressure fall might be subdivided in an initial accelerative phase, an intermediate decelerative phase, and a terminal decelerative phase. The initial phase accelerated with mid and late occlusions. The intermediate phase slowed down with early and to a lesser extent with mid occlusions. The terminal phase was never affected by aortic clamp occlusions. In protocol B, early elevations of systolic LVP were obtained with multiple graded aortic occlusions. The effects of matched LVP elevations of 12 mm Hg on rate of LVP fall were evaluated with the time constant of LVP fall (tau) and showed an interanimal variability ranging from acceleration and a 20% decrease in tau to deceleration and a 35% increase in tau. Changes in tau were moderately correlated with commonly used indexes of contractility (peak +dP/dt, r = -.78; regional fractional shortening, r = -.63). These changes in tau showed a close correlation with the systolic LVP of the test beat, expressed as a percentage of the peak isovolumetric LVP, obtained with total aortic occlusion (r = .984). This suggested that the contraction-relaxation coupling should be analyzed in terms of peak force development rather than contraction velocity or ejection fraction. CONCLUSIONS LVP fall could be subdivided into an initial accelerative phase, an intermediate decelerative phase, and a terminal decelerative phase. Effects of elevations in systolic LVP on rate of LVP fall could be predicted by knowing peak isovolumetric LVP. Nonuniformity of LVP fall and adequate interpretation of load effects should be taken into account when clinical situations or pharmacological interventions are considered. In congestive heart failure, slow LVP fall could mainly reflect working conditions close to isovolumetric rather than relaxation disturbances.
SOME POINTS IN THE PHYSIOLOGY OF SMOOTH MUSCLE AND ITS NERVE REGULATION
Authors: CHARLES W. GREENE
Journal: JAMA (1924)

For test preparations we use the uterus of the rat; also segments of the rat's small intestine, chiefly the duodenum. The use of the rat's uterus for physiologic and pharmacologic purposes has been quite limited, although it is admirably adapted to the purposes. The rabbit and the guinea-pig have heretofore been the standard animals for this type of experimentation, but preparations from the rat are better. Isolated segments of the rat's uterus, prepared by taking the horn and half the body of the organ, and mounting the right and left preparations in duplicate, constitute unique test preparations. The segment should be mounted in a balanced mammalian salt solution, kept at body temperature, and constantly and evenly oxygenated. We have set up the preparations in Harvard warm chamber tubes, so arranged that a change of solution can be promptly and deftly made without disturbing the tension conditions. These tubes are mounted
The evaluation of toll-like receptor 9 (TLR9) as a susceptibility gene for atopy and asthma*1
Authors: M. Singla, T.D. Howard, N. Reijmerink, M.J. Basehore, D.A. Meyers, D.S. Postma, E.R. Bleecker
Journal: Journal of Allergy and Clinical Immunology (2004)
Field Dependence in Young Anorectic and Obese Women
Authors: Harriet I. Basseches, Stephen A. Karp
Journal: Psychotherapy and Psychosomatics (1984)

Bruch and other clinicians working with patients suffering from eating disorders have noted substantial similarity between obese individuals and those with anorexia nervosa with regard to difficulties in achieving autonomous functioning. Although research has substantially supported this view for obese persons, some studies of anorectics have portrayed them as no different from or even more autonomous than normally weighted controls. In an attempt to clarify this discrepancy, the present study evaluated field dependence, a psychological measure reflecting autonomy, among 16 subjects with anorexia nervosa, 16 obese subjects and 16 normally weighted controls. The three groups consisted of females between 12 and 24 years, matched for age, IQ and socioeconomic status. The anorectic and obese groups, while no different from each other, were both significantly more field dependent than the normal controls. The results are viewed as supportive of the Bruch position, stressing similarity of the two eating disorder groups in their limited progress toward autonomous functioning.
Clinical and Non-Clinical Applications of Autogenic Training in Soviet Psychotherapy
Authors: A.M. Sviadosh
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Clinical and Non-Clinical Applications of Autogenic Training in Soviet Psychotherapy Subject Area: Psychiatry and Psychology A.M. Sviadosh A.M. Sviadosh Polytechnical Institute, Department of Biomedical Cybernetics, Leningrad Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 114–115. https://doi.org/10.1159/000286840 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation A.M. Sviadosh; Clinical and Non-Clinical Applications of Autogenic Training in Soviet Psychotherapy. Psychother Psychosom 31 December 1975; 25 (1-6): 114–115. https://doi.org/10.1159/000286840 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Definitions of Chronic Health Conditions in Childhood—Reply
Authors: Johanna H. van der Lee, Lidwine B. Mokkink, Hugo S. Heymans, Martin Offringa
Journal: JAMA (2007)

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Abstract 3541: HOTAIR modulates β-catenin signaling pathway through NLK and NFAT5 in human glioblastoma
Authors: Xuan Zhou, Yu Ren, Lei Han, Chunsheng Kang
Journal: Cancer Research (2014)

Abstract Background Glioblastoma (GBM) is the most common malignant tumor of human central nervures system with poor prognosis. A new class of transcripts, long noncoding RNAs (lncRNAs), has been recently found to be pervasively transcribed in the genome. Recent progress suggests that the involvement of lncRNAs in human cancers could be far more prevalent than previously appreciated. HOTAIR, lncRNA Hox transcript antisense intergenic RNA, has been characterized as a novel hall marker to predict poor prognosis in glioma. HOTAIR serves as a modular scaffold by interacting with the polycomb repressive complex 2 (PRC2) and the lysine-specific demethylase 1 (LSD1) corepressor for element-1-silencing transcription factor (CoREST) complex to silence the HOXD loci in trans. Constitutive activation of the Wnt/β-catenin pathway is a common feature of human cancers and contributes to its development, progression and metastasis. Methods RNA sequencing and qPCR were used to determine HOTAIR expression status in GBM samples. TOP/FOP flash luciferase assays and western blot were employed to identify the effect of HOTAIR's function on the Wnt/β-catenin pathway activity. In addition, FCM, transwell assay, clone formation assay were used to examine HOTAIR's biological function in regulating GBM cell phenotype. Results We show β-catenin pathway is associated to HOTAIR expression by RNA sequencing in GBM cell lines and large scale glioma samples. Besides, increasing NLK and NFAT5 expression, PKM2 and β-catenin pathway inhibition is induced by HOTAIR knockdown in vivo and in vitro. Moreover, HOTAIR knockdown can partially overcome hypoxia stimulation to U87 and U87VIII cells, block cell cycle at G1 phase, and attenuate GBM cell invasion or EMT like transformation. And EZH2 domain may contribute to HOTAIR's biological function. Conclusion Our data indicate that HOTAIR expression is correlated with the overexpression ofβ-catenin pathway activation in both GBM cell lines and tissues. And HOTAIR can serve as a therapeutic target in gliobalstoma, relating its oncogenic effects to activation of β-catenin pathway. Citation Format: Xuan Zhou, Yu Ren, Lei Han, Chunsheng Kang. HOTAIR modulates β-catenin signaling pathway through NLK and NFAT5 in human glioblastoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3541. doi:10.1158/1538-7445.AM2014-3541
Organ donations rose by 10% in UK last year but may be stalling
Authors: J. Wise
Journal: BMJ (2014)

The overall number of people who received an organ transplant rose by 10% in the United Kingdom in the past year, with 4655 carried out by the end of March 2014.

However, the Organ Donation and Transplantation Activity Report 2013-14 shows that four in 10 families refused deceased donation when approached.1 The report said that 456 patients died while waiting for an organ on the active transplant list and that a further 828 were removed …