Ketoconazole in Systemic Mycoses
Authors: PAUL D. HOEPRICH
Journal: Annals of Internal Medicine (1983)

Editorials1 January 1983Ketoconazole in Systemic MycosesPAUL D. HOEPRICH, M.D.PAUL D. HOEPRICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-105_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeeded information on the use of ketoconazole in treating several kinds of systemic mycoses that do not involve the central nervous system is provided by Dismukes and associates in this issue (1). The authors' assessments of the toxicity of ketoconazole are valuable because they were derived from the careful observation of 52 patients.There are problems, however, with the authors' evaluation of the clinical responses to ketoconazole therapy. These extend beyond the two limitations on judgment of efficacy that they noted—namely, permitting escalation of the dose and setting no requirement for either a maximum or a minimum total duration of...References1. DISMUKESSTAMMGRAYBILL WAJ. Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in fifty-two patients. Ann Intern Med. 1983;98:13-20. LinkGoogle Scholar2. ABERNATHYJANSEN RG. Therapy with amphotericin B in North America blastomycosis. Ann Intern Med. 1960;53:1195-203. Google Scholar3. HAY R. The treatment of systemic mycoses caused by specific pathogenic fungi. In: SPELLER DCE, ed. Antifungal Chemotherapy. New York: John Wiley & Sons; 1980:185-331. Google Scholar4. FIESE M. Coccidioidomycosis. Springfield, Illinois: Charles C Thomas; 1958:180-1. Google Scholar5. HILDICK-SMITHBLANKSARKANY GHI. Fungus Diseases and Their Treatment. Boston: Little Brown & Co.; 1964:241. Google Scholar6. EMMONSBINFORDUTZKWON-CHUNG CCJK. Medical Mycology. 3rd ed. Philadelphia: Lea & Febiger; 1977:210, 236, 308. Google Scholar7. TOSHDOTOSAROSIPARKER FIGJ. Evaluation of amphotericin B therapy of histoplasmosis. In: AJELLO L, CHICK EW, FURCOLOW ML, eds. Histoplasmosis: Proceedings of the Second National Conference. Springfield, Illinois: Charles C Thomas; 1971:418-23. Google Scholar8. WATANAKUNAKORN C. Acute disseminated histoplasmosis with spontaneous recovery. South Med J. 1973;66:1065-6. CrossrefMedlineGoogle Scholar9. KERKERINGDUMASHADOMY TRS. The evolution of pulmonary cryptococcosis. Ann Intern Med. 1981;94:611-6. LinkGoogle Scholar10. PARKERSAROSITOSH JGF. Treatment of extracutaneous sporotrichosis. Arch Intern Med. 1970;125:858-63. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLate Dissemination of PulmonaryTreatment of Blastomycosis and Histoplasmosis with Ketoconazole Results of a Prospective Randomized Clinical TrialNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES MYCOSES STUDY GROUP 1 January 1983Volume 98, Issue 1Page: 105-105KeywordsCentral nervous systemInformation technologySystemic mycosesToxicity Issue Published: 1 January 1983 PDF DownloadLoading ...