tbuckley/cabot-search huggingface dataset:
Endothelin-1 depresses tracheal mucus velocity in ovine airways via ET-A receptors.
Authors: J R Sabater, R Otero, W M Abraham, A Wanner, T G O'Riordan
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Endothelin-1 (ET-1) is a potent constrictor of bronchial smooth muscle, but there is limited information on its actions on the airway mucociliary clearance in vivo. The purpose of this study was to determine (1) the effect of aerosolized ET-1 on tracheal mucus velocity (TMV), a marker of mucociliary clearance, in sheep and (2) if the ET-1-induced effects were mediated by ET-A or ET-B receptors. To measure TMV, radiopaque teflon particles were insufflated into six intubated, spontaneously breathing, adult sheep, and the velocity at which these particles traveled up the trachea was measured using a previously reported roentgenographic technique. After baseline TMV measurements, 50 breaths of either ET-1 (10(-7) M) or vehicle (phosphate-buffered saline) were aerosolized into the airways. TMV measurements were then obtained over a 2-h period. After exposure to ET-1, mean TMV decreased significantly as compared with vehicle, the effects being most marked within 30 min after administration (54%, p < 0.05). On subsequent days, animals were pretreated with an aerosolized ET-A receptor antagonist (BQ-123) or an ET-B receptor antagonist (BQ-788) before exposure to ET-1. When ET-1 was given after BQ-123, no significant drop in TMV was noted. In contrast, pretreatment with BQ-788 exhibited no protective effect on the decrease in TMV. The ET-1 effects were not influenced by pretreatment with either the cyclo-oxygenase inhibitor indomethacin or the leukotriene receptor antagonist MK-571, indicating that ET-1-induced depression in TMV does not involve the activation of prostanoids or peptide leukotrienes. Thus, exogenous ET-1 reduces TMV, an in vivo effect that is mediated through stimulation of ET-A receptors.
TIE2-expressing monocytes regulate revascularisation of the ischaemic limb
Authors: Ashish S Patel, Alberto Smith, Silvia Nucera, Daniela Biziato, Prakash Saha, Rizwan Q Attia, Julia Humphries, Steven P Grover, Katherine Mattock, Oliver T Lyons, Luca G Guidotti, Richard Siow, Aleksandar Ivetic, Stuart Egginton, Matthew Waltham, Luigi Naldini, Michele De Palma, Bijan Modarai
Journal: The Lancet (2013)
Training of a standardized natural orifice transluminal endoscopic surgery cholecystectomy using an ex vivo training unit
Authors: S. Gillen, A. Fiolka, M. Kranzfelder, P. Wolf, M. Feith, A. Schneider, A. Meining, H. Friess, H. Feussner
Journal: Endoscopy (2011)

Background and study aims: The endoscopic–laparoscopic interdisciplinary training entity (ELITE) is one of the first training models for the training of natural orifice transluminal endoscopic surgery (NOTES) and conventional laparoscopic and endoscopic skills. The current study was designed to assess whether the effect of surgical simulation with an ex vivo training unit is relevant to surgical practice in the operating room and who, in particular, might benefit from this training.
Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration
Authors: Jiansheng Huang, Emily Barr, David A. Rudnick
Journal: Hepatology (2012)

The studies reported here were undertaken to define the regulation and functional importance of zinc-dependent histone deacetylase (Zn-HDAC) activity during liver regeneration using the mouse partial hepatectomy (PH) model. The results showed that hepatic HDAC activity was significantly increased in nuclear and cytoplasmic fractions following PH. Further analyses showed isoform-specific effects of PH on HDAC messenger RNA (mRNA) and protein expression, with increased expression of the class I HDACs, 1 and 8, and class II HDAC4 in regenerating liver. Hepatic expression of (class II) HDAC5 was unchanged after PH; however, HDAC5 exhibited transient nuclear accumulation in regenerating liver. These changes in hepatic HDAC expression, subcellular localization, and activity coincided with diminished histone acetylation in regenerating liver. The significance of these events was investigated by determining the effects of suberoylanilide hydroxyamic acid (SAHA, a specific inhibitor of Zn-HDAC activity) on hepatic regeneration. The results showed that SAHA treatment suppressed the effects of PH on histone deacetylation and hepatocellular bromodeoxyuridine (BrdU) incorporation. Further examination showed that SAHA blunted hepatic expression and activation of cell cycle signals downstream of induction of cyclin D1 expression in mice subjected to PH.The data reported here demonstrate isoform-specific regulation of Zn-HDAC expression, subcellular localization, and activity in regenerating liver. These studies also indicate that HDAC activity promotes liver regeneration by regulating hepatocellular cell cycle progression at a step downstream of cyclin D1 induction.
Breast Cancer Prevention Trial in Limbo
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ketosis resistance in fibrocalculous pancreatic diabetes: II. Hepatic ketogenesis after oral medium-chain triglycerides
Authors: C.S. Yajnik, B.S. Sardesai, D.S. Bhat, S.S. Naik, K.N. Raut, K.M. Shelgikar, H. Orskov, K.G.M.M. Alberti, T.D.R. Hockaday
Journal: Metabolism (1997)
Delirium Following the Treatment of Acute Rheumatism by Salicylic Acid
Authors: T. D. Acland
Journal: BMJ (1881)

THE BRITISh MEDICAL 7OURNAL.337 days to a week after the commencement of the medicine; in none did cardiac complications arise during the course of the treatment and, I think, the convalescence was more rapid than in cases I have seen treated by the salicylate of soda.In Case v, there was a slight relapse, probably owing to the medi-
CORONARY PLAQUE BURDEN BY QUANTITATIVE CORONARY ANGIOGRAPHY CORRELATES WITH PLAQUE BURDEN BY CT CORONARY ANGIOGRAPHY AND INTRAVASCULAR ULTRASOUND
Authors: Anna M. Kalynych, Gustavo Vazquez, Dimitri Karmpaliotis, Zhen Qian, Eric Krivitsky, Idean B. Marvasty, Sarah Rinehart, Szilard Voros
Journal: Journal of the American College of Cardiology (2010)
External Validation of a Prognostic Model Predicting Overall Survival in Metastatic Castrate-resistant Prostate Cancer Patients Treated with Abiraterone
Authors: Praful Ravi, Joaquin Mateo, David Lorente, Zafeiris Zafeiriou, Amelia Altavilla, Roberta Ferraldeschi, Spyridon Sideris, Emily Grist, Alan Smith, Sophia Wong, Diletta Bianchini, Gerhardt Attard, Johann S. de Bono
Journal: European Urology (2014)
Chronic Pyelonephritis: Relative Incidence in Transplant Recipients
Authors: M. H. Gault, J. B. Dossetor
Journal: New England Journal of Medicine (1966)

IN 1963 Murray and Harrison1 reported that glomerulonephritis was the commonest disease among 50 patients undergoing kidney transplantation. Similar findings have been reported from other transplant centers,2 3 4 5 6 7 8 9 10 11 12 13 as well as in a report of 71 patients with terminal chronic uremia in which those with a doubtful diagnosis had been excluded.14 Including patients from the latter group, 232 of the total of 386 had glomerulonephritis as compared with 87 with pyelonephritis (Table 1) The 232 includes some with both glomerulonephritis and pyelonephritis, and the 87 includes patients with pyelonephritis secondary to anatomic abnormalities of the urinary tract. The age of patients . . .
Food Labeling Claims
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II.
Authors: J Holoshitz, A Matitiau, I R Cohen
Journal: Journal of Clinical Investigation (1984)

We have been studying the pathogenesis of adjuvant arthritis in rats using a long-term cell line of T lymphocytes, the A2 line, which can induce polyarthritis and can also be used to vaccinate rats against adjuvant arthritis. Although line A2 was selected for its proliferative response to mycobacteria, it also responded to collagen type II. To elucidate its role of responsiveness to collagen type II and the relationship between arthritogenicity and vaccination, we cloned A2 and selected a subline A2b. We now report that subline A2b, which bore a marker of helper/delayed hypersensitivity T lymphocytes, was strongly arthritogenic, but could not vaccinate against arthritis. Moreover, A2b showed no response to collagen type II. Therefore, reactivity to collagen type II is not a requisite for arthritogenicity, and mediation of arthritis and vaccination can be distinct properties of different populations of T lymphocytes.
Antibody response of rabbit blood lymphocytes in vitro. Kinetics, clone size, and clonotype analysis in response to streptococcal group polysaccharide antigens.
Authors: D G Braun, J Quintáns, A L Luzzati, I Lefkovits, S E Read
Journal: The Journal of Experimental Medicine (1976)

Peripheral blood lymphocytes (PBL) of rabbits previously hyperimmunized against streptococcal groups A and A-variant antigens were stimulated in vitro by the corresponding vaccines to produce group-specific antibody. This response was dependent on an optimal cell density (2 X 10(6) cells/ml), on the presence of antigen, it was specific and cross-reactive due to a shared rhamnose backbone of the two polysaccharide antigens, and it was highly selective, such that in a 42-55-day culture 1 out of 20 viable cells was a specific PFC. During the exponential increase of the antibody concentration at a constant number of PFC, antibodies were secreted at a rate of 2.4 X 10(4) molecules/s per cell until a plateau level of antibody (40 mug/culture) was reached. The microculture system was used to determine the minimal frequency of group polysaccharide-specific precursor cells in the blood. Independent of the time elapsed since the last immunization this frequency was 1-3 X 10(-5), i.e., in the range of 1-2.8 X 10(2) precursor cells per ml blood. This number was further used together with the clonotype analysis of the culture supernates to calculate the frequencies of precursors of major and minor clonotypes. A hierachy of persisting clonal memory precursor cells was found indicating that clonal dominance is determined by locked-in frequency patterns and therefore it is a phenomenon based on numbers of cells that respond to the antigen.
Elevated Hepatic Venous Renin Activity in Cirrhosis: Evidence for Impaired Hepatic Inactivation and Portal Venous Origin.
Authors: David E. Barnardo
Journal: Annals of Internal Medicine (1969)

s1 May 1969Elevated Hepatic Venous Renin Activity in Cirrhosis: Evidence for Impaired Hepatic Inactivation and Portal Venous Origin.David E. Barnardo, M.R.C.P., Cameron G. Strong, M.D., William P. Baldus, M.D., F.A.C.P.David E. Barnardo, M.R.C.P.Search for more papers by this author, Cameron G. Strong, M.D.Search for more papers by this author, William P. Baldus, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1065_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIncreased activity of the renin-angiotensin system in cirrhosis may aggravate salt and water retention by promoting the release of aldosterone. It has been postulated that elevation of plasma renin activity (PRA) due to increased production by the kidney may be augmented by impaired hepatic inactivation in the diseased liver, but this is unconfirmed.Therefore, PRA was measured by the method of Boucher and associates in blood taken simultaneously from the hepatic vein and a peripheral vein or artery (there being no significant arterioventricular difference) in 18 patients with cirrhosis and 13 control subjects without liver disease.As expected, peripheral PRA... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLa Sindrome Epato-RenaleThe Renin-Angiotensin SystemRenal failure in the patient with cirrhosisPlasma renin level in hepatic cirrhosis 1 May 1969Volume 70, Issue 5Page: 1065-1065KeywordsAldosteroneArteriesBloodCirrhosisLiver diseasesPlasma renin activityRenal diseasesSaltsVeins Issue Published: 1 May 1969 PDF DownloadLoading ...
Safety and immunogenicity of 2009 pandemic influenza A H1N1 vaccines in China: a multicentre, double-blind, randomised, placebo-controlled trial
Authors: Xiao-Feng Liang, Hua-Qing Wang, Jun-Zhi Wang, Han-Hua Fang, Jiang Wu, Feng-Cai Zhu, Rong-Cheng Li, Sheng-Li Xia, Yu-Liang Zhao, Fang-Jun Li, Shao-Hong Yan, Wei-Dong Yin, Kang An, Duo-Jia Feng, Xuan-Lin Cui, Feng-Chun Qi, Chang-Jun Ju, Yu-Hui Zhang, Zhi-Jun Guo, Ping-Yu Chen, Ze Chen, Kun-Ming Yan, Yu Wang
Journal: The Lancet (2009)
A double-blind placebo-controlled study of thymostimulin (TP-1) for the treatment of atopic eczema
Authors: J. I. HARPER, U. A. MASON, T. R. WHITE, R.C.D. STAUGHTON, J. R. HOBBS
Journal: British Journal of Dermatology (1991)

Summary Twenty-nine patients with severe atopic eczema were entered into a randomized double-blind, placebo-controlled trial of the polypeptide thymus extract, thymostimulin (TP-1). The treatment period was 10 weeks with a subsequent follow-up period of up to 1 year. of the 18 patients receiving TP-1 and the 11 patients on the placebo. 15 and 11 patients, respectively, were fully evaluable. There was no significant difference in either clinical or immunological status between the two treatment groups at baseline. At the 3-month follow-up clinic visit there was a statistically significant difference in the total clinical score, calculated as a percentage of baseline, in favour of the TP-1-treated patients. This difference was not maintained in the subsequent follow-up period and was not accompanied by an improvement in the patient's subjective well-being. There was no signitticant difference between the treatment groups with respect to the immunological parameters as measured at the 3-month clinic visit.
Abstract 1831: Using narrative to transform cancer communication: Impact of a cervical cancer storyline on primetime television
Authors: Sheila T. Murphy, Sandra de Castro Buffington, Heather Hether, Lourdes A. Baezconde-Garbanati
Journal: Cancer Research (2011)

Abstract Epidemiological evidence reveals that Hispanic women lag behind all other ethnic groups in their rate of cervical cancer screening (National Health Interview Survey, 2006). Can stories succeed where more traditional cancer campaigns have faltered? Funding by the National Cancer Institute enabled researchers at Hollywood, Health &amp; Society, the Annenberg School for Communication and Journalism, and the Institute for Prevention Research at the University of Southern California to encourage writers of primetime programming to include accurate information regarding cervical cancer. Purpose of study: This study examined whether a popular Spanish language telenovela could impact Hispanic viewers’ knowledge, attitudes and behavior with respect to cervical cancer screening. Experimental procedures: This was assessed by a quantitative survey of viewers before and after the fictional character of Dora in a Telemundo telenovela, El Clon, had an abnormal pap test. Results: Statistical comparisons between the pretest and posttest surveys revealed that after seeing cervical cancer storyline viewers were 6 times more likely to know that a pap test detects cervical cancer; 4 times more likely to know that pap tests are available for free or at low cost; 80 percent more likely to know pap women should have a pap test at least every 2 years; and 80 percent more likely to intend to have pap in next 2 years. This shift was strongest among viewers who identified with Dora and reported being absorbed or “transported” while viewing. Conclusions: A cervical cancer storyline on a popular telenovela was significantly associated with greater level of knowledge and intention to have pap test in the next 2 years. Implications of these results and the use of entertainment education in cancer communication more generally will be discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1831. doi:10.1158/1538-7445.AM2011-1831
Endoscopic intracavitary vacuum therapy of Boerhaave's syndrome: a case report
Authors: G. Loske, T. Schorsch, C. Müller
Journal: Endoscopy (2010)

Boerhaave's syndrome is a difficult therapeutic challenge. The transmural laceration of the distal esophagus leads to mediastinal inflammation due to translocation of digestive juices into the open mediastinum. The vacuum-assisted closure therapy is well established in the treatment of chronic surface wounds [1]. The successful adaptation of this technique for intracorporeal wounds has been recently demonstrated for anastomotic leakage after anterior resection of the rectum [2]. We modified this technique in order to successfully treat a case of esophageal anastomotic leakage [3]. We describe here the effectiveness of the procedure in the treatment of Boerhaave’s syndrome.
Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
Authors: Laurence Catley, Ellen Weisberg, Tanyel Kiziltepe, Yu-Tzu Tai, Teru Hideshima, Paola Neri, Pierfrancesco Tassone, Peter Atadja, Dharminder Chauhan, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood (2006)

Histone deacetylase (HDAC) inhibitors have shown cytotoxicity as single agents in preclinical studies for multiple myeloma (MM) cells. LBH589 is a novel hydroxamic acid derivative that at low nanomolar concentrations induces apoptosis in MM cells resistant to conventional therapies via caspase activation and poly-(ADP-ribose) polymerase (PARP) cleavage. Significant synergistic cytotoxicity was observed with LBH589 in combination with bortezomib against MM cells that were sensitive and resistant to dexamethasone (Dex), as well as primary patient MM cells. LBH589 at low nanomolar concentrations also induced alpha-tubulin hyperacetylation. Aggresome formation was observed in the presence of bortezomib, and the combination of LBH589 plus bortezomib induced the formation of abnormal bundles of hyeracetylated alpha-tubulin but with diminished aggresome size and apoptotic nuclei. These data confirm the potential clinical benefit of combining HDAC inhibitors with proteasome inhibitors, and provide insight into the mechanisms of synergistic anti-MM activity of bortezomib in combination with LBH589.
Assessment and management of psychosis with coexisting substance misuse: summary of NICE guidance
Authors: T. Kendall, P. Tyrer, C. Whittington, C. Taylor
Journal: BMJ (2011)

Many people with mental health problems use substances (including illicit drugs and alcohol), and for people with psychosis (predominantly schizophrenia and bipolar disorder), substance misuse occurs more frequently than in the general population.1 2 For example, a 1990 study in the United States reported a 47% lifetime prevalence rate of substance misuse among people with schizophrenia and 60% among people with bipolar disorder; in the general population, the substance misuse rate was 16%.2 3 People with psychosis commonly take various non-prescribed substances to cope with their symptoms, and in about a third of people with psychosis, this amounts to hazardous, harmful, or dependent use.4 Among people with psychosis, those with coexisting substance misuse have a higher risk of relapse and admission to hospital,5 higher mortality,6 and higher levels of unmet needs. This is partly because the substances used may exacerbate the psychosis or interfere with pharmacological or psychological treatment. This article summarises the most recent recommendations from the National Institute for Health and Clinical Excellence (NICE) on the assessment and management of psychosis and coexisting substance misuse in adults and young people.7 NICE recommendations are based on systematic reviews of best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the Guideline Development Group’s experience and opinion of what constitutes good practice; this was often necessary for this guidance because there was evidence for the treatment of either psychosis or substance misuse but little evidence for treatment when both conditions were present. Evidence levels for the recommendations are given in italic in square brackets. ### Working with people with psychosis and coexisting substance misuse