tbuckley/cabot-search huggingface dataset:
ELDERLY PATIENTS ARE LESS LIKELY TO RECEIVE EVIDENCE-BASED MEDICATIONS INDICATED FOR SYSTOLIC HEART FAILURE: RESULTS FROM THE STUDY OF ANEMIA IN A HEART FAILURE POPULATION (STAMINA-HFP) REGISTRY
Authors: Ileana L. Pina, Rebecca S. Boxer, Douglas D. Schocken, G. Michael Felker, Carla A. Dupree, Alan B. Miller, Mandeep R. Mehra, Javed Butler, J. Herbert Patterson, Lynne E. Wagoner, Jalal K. Ghali, Stephanie H. Dunlap, Kirkwood F. Adams
Journal: Journal of the American College of Cardiology (2010)
Abstract P6-06-16: Young age as a good prognostic factor in de novo metastatic breast cancer
Authors: GE Lee, S Dawood, BA Haaland, PS Tan, N Bhoo-Pathy, RA Dent
Journal: Cancer Research (2013)

Abstract Background While breast cancer is relatively rare in young women under the age of 40, its incidence is increasing and accounts for up to 40% of all female cancers. Young age at diagnosis is associated with a poorer prognosis in early breast cancers; however little is known about the natural history of young women with metastatic breast cancer. We aim to evaluate the effect of age on breast-cancer specific survival (BCS) and overall survival (OS) for patients with de novo metastatic breast cancer using data from the SEER registry. Methods We retrospectively analyzed 14155 patients with de novo metastatic breast cancer from the SEER registry between 2000 and 2009. Young women were defined as 50 years and below and further subdivided into three groups: 20-34, 35-39, and 40-49 years. Age 50-69 years served as a comparison group. Unadjusted overall survival (OS) and breast cancer specific survival (BCS) were accessed using Kaplan-Meier plots and compared across groups using log-rank tests. Cox proportional hazards models were then fitted to determine the association between survival end point and age after adjusting for patient and tumor characteristics. Results 546 (3.9%) patients were age 20-34 years, 750 (5.3%) were 35-39 years, 3049 (21.5%) were 40-49 years and 9810 (69.3%) patients were 50-69 years. Median BCS among patients age 20-34, 35-39, 40-49 and 50-69 years was 30, 33, 35, 28 months respectively (P&amp;lt;0.0001). Median BCS among patients with estrogen receptor positive disease who were age 20-34, 35-39, 40-49 and 50-69 years was 43, 42, 51, 37 months respectively (P&amp;lt;0.0001). Similarly median BCS among patients with estrogen receptor negative disease who were age 20-34, 35-39, 40-49 and 50-69 years was 21, 18, 18, 17 months respectively (P&amp;lt;0.0001). In the multivariable model compared to patients who were age 50 -69 years those aged 20-34 years (HR 0.88, 95% CI 0.78-0.99), 35-39 years (HR 0.82, 95% CI 0.74-0.91) and 40-49 years (HR 0.84, 95% CI 0.79-0.89) had a significantly decreased risk of death from breast cancer. Similar results were obtained for OS. Conclusion Younger patients defined by age less than 50 years had a better BCS and OS when compared against older age group in the setting of de novo metastatic breast cancer. This may be explained by lack of important comorbidities, relatively good performance status as well as ability to tolerate more lines of chemotherapies. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P6-06-16.
Influence of Methotrexate and Azathioprine on Radiologic Progression in Rheumatoid Arthritis
Authors: Maurice E. C. Jeurissen, Agnes M. Th. Boerbooms, Levinus B. A. van de Putte, Wim H. Doesburg, Albert M. Lemmens
Journal: Annals of Internal Medicine (1991)

Objective: To compare the effects of azathioprine and methotrexate on progression of radiologic damage in patients with rheumatoid arthritis. Design: Double-blind, randomized 48-week trial. Patients: Sixty-four patients with active rheumatoid arthritis who either have not responded to or who have reacted with side effects to at least parenteral gold and D-penicillamine. Interventions: Either azathioprine, 100 mg daily, or methotrexate, 7.5 mg weekly, was administered orally. Depending on the clinical effect after 8 weeks, the dosage was increased to either azathioprine, 150 mg, or methotrexate, 15 mg. The dosages for nonsteroidal anti-inflammatory drugs and prednisone were held stable. Measurements: Clinical and laboratory assessments were done by the same physician every 4 weeks for the first 24 weeks and every 8 weeks thereafter. Radiographs of hands, wrists, and feet obtained at baseline and after 24 and 48 weeks were scored by one rheumatologist blinded to medication and clinical findings. Main Results: Initial radiologic scores were comparable in both groups and correlated with disease duration (r = 0.38). An intention-to-treat analysis after 24 and 48 weeks showed significantly fewer new erosions in the methotrexate group compared with the azathioprine group (difference, 2.0 [95% CI, 0.2 to 3.9] and 3.5 [CI, 1.3 to 5.8], respectively). The change in total joint score was also significantly less pronounced in the methotrexate group compared with the azathioprine group after 24 weeks (difference, 2.8 [CI, 0.2 to 5.2]) and after 48 weeks (difference, 3.9 [CI, 0.3 to 7.4]). Radiologic stabilization after 48 weeks was present in 10% of the azathioprine group compared with 29% of the methotrexate group. Conclusions: Patients with rheumatoid arthritis treated with low-dose methotrexate showed significantly less radiologic progression than patients treated with azathioprine. This result suggests that methotrexate therapy is clinically superior in these patients.
Role of Schools of Public Health
Authors: James L. Whittenberger
Journal: New England Journal of Medicine (1964)

THE role of the graduate school of public health in the training of physicians has been a controversial one. The need for schools of public health has been questioned by some medical educators in recent years, mainly because of developments in departments of preventive medicine in medical schools.Schools of public health originated in this country about fifty years ago, in response to demands that were not being met by medical schools and by engineering schools. One of the earliest was established in Boston in 1913, when the Harvard Medical School and the Massachusetts Institute of Technology combined to offer . . .
Simplified dithranol treatment for psoriasis*
Authors: R.H. SEVILLE
Journal: British Journal of Dermatology (2006)

Progressive simplification of dithranol therapy has made treatment at home more acceptable. This has included omitting ultra‐violet light, talc and dressings, and substituting an ordinary bath instead of one containing tar. A stiffened dithranol 0.5% ointment was found to be slightly more effective than the best paste hitherto employed. It was also very much easier to use.
P497Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in experimental rats:
Authors: H H M A Atteia, MHMA Arafa, NSMS Said, HRA Abd-Elaziz
Journal: Cardiovascular Research (2014)

Objectives: The possible effectiveness of resveratrol, a polyphenol found predominantly in grapes, administration on doxorubicin-induced cardiac toxicity and fibrosis was investigated.
Partial hepatectomy or orthotopic liver transplantation for the treatment of resectable hepatocellular carcinoma? A cost-effectiveness perspective
Authors: Fran�ois P. Sarasin, Emiliano Giostra, Gilles Mentha, Antoine Hadengue
Journal: Hepatology (1998)

The treatment of patients with compensated liver cirrhosis and small hepatocarcinomas remains controversial. Whereas partial hepatectomy (PH) is currently recommended, the role of orthotopic liver transplantation (OLT) has become progressively accepted. We used the techniques of decision analysis to measure the clinical benefits and the economic consequences of immediate resection versus transplantation in patients with compensated cirrhosis and who were diagnosed with small hepatocellular carcinoma (HCC). We restricted our analysis to patients with resectable carcinomas, which is either solitary tumor (< or = 5 cm in diameter), or multiple tumors (up to 3), none being > 3 cm in diameter and, in both cases, no tumor invasion of blood vessels. We took into account the risks of tumor spreading and dissemination and/or development of decompensated cirrhosis while waiting for donor organs because organ shortage is presented as the main obstacle to transplantation in these patients. Our analysis suggests that orthotopic liver transplantation (OLT) offers a substantial survival benefit compared with resection, ranging from a minimum of 1 year to a maximum of 4.7 years depending on treatment-related survival rates. However, the magnitude of this benefit relies on the availability of an organ donor; therefore, if the waiting period exceeds 6 to 10 months, depending on tumor growth pattern, the increase in life expectancy provided by transplantation is overwhelmed by the risks that patients face while waiting for transplantation. Consequently, partial resection becomes the preferred strategy. The predicted marginal cost-effectiveness ratios of transplantation compared with resection would range between $44,454 and $183,840 per additional year gained mainly influenced by the time delay before getting a transplant. We conclude that compared with partial hepatectomy (PH), OLT for resectable hepatocarcinoma(s) offers substantial survival benefit among well-targeted subgroups of patients as long as an organ donor is available within a maximal 6 to 10 months time delay, which is a plausible scenario in most centers with a liver transplant program. However, the marginal cost-effectiveness ratios incurred by this strategy are higher than that of many other current medical interventions.
Taking Issue: Pluralism and Casuistry in Bioethics
Authors: B. B. Kilburn
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doctors and homosexuality Homosexuals deserve better from doctors
Authors: V Calland, T Worden, B Williams, M C Hayes-Allen, L Rose
Journal: BMJ (1994)

EDITOR, - The correspondence1 concerning Lynn Rose's paper on homophobia2 was a major topic of the discussion at a recent monthly meeting of the Lesbian and Gay Health Workers Association. Members of the association represent a wide range of health workers, and we believe that we can offer a consolidated opinion for all homosexuals working in health care.

We believe that it is essential to identify the key facts in the debate. Homophobia may be the wrong word for the attitude of malice towards homosexual people, but nothing can disguise the fact such an attitude can be found throughout the health service in a scattering of staff. Fortunately, an equal number of heterosexuals will support and defend the right …
Hazards of Hyperosmolar Solutions
Authors: DONALD G. VIDT
Journal: Annals of Internal Medicine (1973)

Editorial Notes1 October 1973Hazards of Hyperosmolar SolutionsDONALD G. VIDT, M.D.DONALD G. VIDT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-4-599 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this issue (pp. 511-517), Raja and associates raise the question, again, of the use of hyperosmolar dialysis solutions for peritoneal dialysis, by presenting an alternative to dextrose or sorbitol dialysate in selected clinical situations. The potentially hazardous complications of hyperglycemia, hypovolemia, hypernatremia, and hyperosmolar coma have been widely recognized and were emphasized in an earlier editorial in this journal (1). These complications and most of the solution-related deaths have been associated with 7% dextrose dialysate, used to facilitate volume reduction. The results of a workshop on the optimal choice of peritoneal dialysis solutions have been reported in a recent...References1. TENCKHOFF H: Choice of peritoneal dialysis solutions (editorial). Ann Intern Med 75:313-314, 1971 LinkGoogle Scholar2. VIDT D: Recommendations on choice of peritoneal dialysis solutions (editorial note). Ann Intern Med 78:144-146, 1973 LinkGoogle Scholar3. WOODSALBERTI HK: Dangers of intravenous fructose. Lancet 2:1354-1357, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD G. VIDT, M.D.Affiliations: Department of Hypertension and Nephrology Cleveland Clinic Foundation Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1973Volume 79, Issue 4Page: 599-600KeywordsFructoses ePublished: 13 March 2020 Issue Published: 1 October 1973 PDF downloadLoading ...
PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages
Authors: Katka Szilagyi, Alexander B. Meijer, Annette E. Neele, Paul Verkuijlen, Michael Leitges, Sandrine Dabernat, Elisabeth Förster-Waldl, Kaan Boztug, Alexandre Belot, Taco W. Kuijpers, Georg Kraal, Menno P. J. de Winther, Timo K. van den Berg
Journal: Cardiovascular Research (2014)

AimsUptake of oxidized lipoprotein particles (oxLDL) and foam cell formation by macrophages is one of the first steps in the development of atherosclerosis. Recently, protein kinase C δ (PKCδ) has been implicated as a regulator of oxLDL uptake and foam cell formation via down-regulation of PKCβ and scavenger receptors CD36 and SR-A expression. Here, we describe studies in which we have re-evaluated the role of PKCδ in oxLDL uptake and foam cell formation.
Destructive Periodontal Disease and Tobacco and Cannabis Smoking
Authors: Philippe P. Hujoel
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Degranulation of eosinophils mediated by intercellular adhesion molecule-1 and its ligands is involved in adhesion molecule expression on endothelial cells–selective induction of VCAM-1
Authors: J CHIHARA, T YAMAMOTO, H KAYABA, T KAKAZU, D KURACHI, J YAMAMOTO, S IWASA, K IIDA, O URAYAMA, Y KOBAYASHI
Journal: Journal of Allergy and Clinical Immunology (1999)
Congenital Aneurysm of the Membranous Portion of the Ventricular Septum
Authors: RICHARD W. CAMPBELL, E. F. STEINMETZ, CHARLES H. HELMEN
Journal: Circulation (1964)

A case of an isolated aneurysm of the ventricular septum with a loud holosystolic murmur at the fourth left interspace is presented. The origin of the murmur is ascribed to the aneurysm of the ventricular septum.
The co-receptor BTLA negatively regulates human Vγ9Vδ2 T-cell proliferation: a potential way of immune escape for lymphoma cells
Authors: Julie Gertner-Dardenne, Cyril Fauriat, Florence Orlanducci, Marie-Laure Thibult, Sonia Pastor, Jude Fitzgibbon, Reda Bouabdallah, Luc Xerri, Daniel Olive
Journal: Blood (2013)
Alternatives to Psychiatric Hospitalization
Authors: Loren R. Mosher
Journal: New England Journal of Medicine (1983)

Two major recent reviews and a doctoral dissertation, written by scientists with no obvious axes to grind, have pointed out that every study (7 in one review, 10 in the other, and 20 in the dissertation) comparing nonhospital with in-hospital psychiatric treatment has found the former to be as good as or better1 2 3 than the latter, and usually cheaper.2 , 3 The question can, of course, be raised whether the studies were biased by the presence of large numbers of patients in the outpatient groups who were not ill enough to require hospitalization. Kiesler's review2 addresses this issue directly, since it includes . . .
THE QUANTITATIVE RELATIONSHIP BETWEEN IMMUNE SERUM AND INFECTIVE DOSE OF PARASITES AS DEMONSTRATED BY THE PROTECTION TEST IN MONKEY MALARIA
Authors: Lowell T. Coggeshall, Monroe D. Eaton
Journal: The Journal of Experimental Medicine (1938)

The minimal infective dose of Plasmodium knowlesi for rhesus monkeys was found in this study to be between 1 and 10 parasites when injected intraperitoneally. As the dose of parasites is increased, the length of time prior to the appearance of circulating parasites is decreased. However, the severity of the infection once it is established is independent of the initial dose of parasites. In passive protection experiments a quantitative relationship was demonstrated between the number of parasites in the inoculum and the effective amount of immune serum given at the time of infection and in equal doses daily for 9 days thereafter. The smaller the inoculum, the less the quantity of immune serum required to prevent the death of the animal. When relatively large amounts of immune sera and small numbers of parasites were used in the protection experiment, infection was prevented.
Chronic Respiratory Disease in Hemp Workers
Authors: AREND BOUHUYS
Journal: Annals of Internal Medicine (1976)

Many soft-hemp workers with more than 20 years' exposure to dust have chronic respiratory symptoms and obstructive lung function loss. During 7 years of follow-up, these workers had significantly higher occurrences of chronic cough and phlegm and of dyspnea than control subjects and a significantly larger annual decline of forced expiratory volume in 1 second (FEV1.0) than control subjects, with a particularly marked difference between 20- to 44-year-old nonsmoking controls and hemp workers. We believe that deterioration of lung function among hemp workers begins before the age of 45 and that it continues even if further exposure to dust ceases. Textile workers should be advised to avoid further exposure to dust at a time when their ventilatory lung function (in the absence of effects of acute exposure) is sufficient to prevent future development of disabling function loss.
F-18 Fluorodeoxyglucose PET/CT Findings in Active Hiccups
Authors: C Fitzhugh Yeatman, Satoshi Minoshima
Journal: Clinical Nuclear Medicine (2009)

A 62-year-old man with nonsmall cell lung cancer presented for a staging F-18 fluorodeoxyglucose (FDG) positron emission tomography and computed tomography. Preimaging assessment determined that the patient had a 2-week history of persistent hiccups. The hiccups were unmanageable and persisted throughout the examination from FDG injection to imaging. Persistent hiccups can be seen in patients with advanced cancer. Characteristic findings on FDG positron emission tomography and computed tomographyare presented here.
Plans for genetic testing of German civil servants stirs controversy
Authors: Annette Tuffs
Journal: BMJ (2005)

The National Ethics Council, an advisory committee of the German government, has recommended that there should be a new law to safeguard against genetic discrimination of employees in Germany. But the move has stirred up controversy because, it is claimed, the guidance is unclear on what time span prognostic tests should cover.

Kristiane Weber-Hassemer, chairwoman of the committee, said that genetic tests should not be routinely used, but they should be considered, for civil servants who are in safe, lifelong jobs. …
Problem Formulation: The Problem-Oriented Record
Authors: RALPH S. RYBACK, JOHANNA S. GARDNER
Journal: American Journal of Psychiatry (1973)

The authors discuss the benefits of using a problem-oriented record (chiefly the clearer documentation of treatment, the simplification of communication among mental health personnel, and the stimulation of further research) and the problems inherent in applying this approach to psychiatric practice. Both the benefits and the problems are illustrated by means of two case reports.
THE PRODUCTION OF PURPURA BY DERIVATIVES OF PNEUMOCOCCUS
Authors: Louis A. Julianelle, Hobart A. Reimann
Journal: The Journal of Experimental Medicine (1927)

1. The purpura-producing principle of Pneumococcus is non-antigenic in the sense that it does not stimulate the formation of antibodies. 2. White mice acquire an increased resistance to purpura as a result of repeated injections of toxic doses of the purpura substance. 3. The serum of rabbits immunized with the purified purpura principle, with "S" and "R" strains of Pneumococcus or with cell extracts, autolysates or the nucleoprotein fraction of the organism does not confer upon white mice protection against purpura. 4. The purpura principle does not exist preformed in the cell, but is rather an autolytic derivative; since it is formed only when pneumococci undergo autolysis, and it is not found when the autolytic ferments are inactivated. 5. The purpura substance is associated with the proteose fraction of active pneumococcus extracts.
Meandering Pathway Leading From Genotyping to Personalized Management of Long-QT Syndrome
Authors: Silvia G. Priori, Carlo Napolitano
Journal: Circulation (2012)

L ong-QT syndrome (LQTS) has been the first inherited arrhythmogenic syndrome to be extensively characterized in clinical cardiology.2][3] The publication of Keating's works generated a great deal of excitement among those involved in the care of LQTS patients because it became clear that the possibility of identifying in the clinic the DNA variants that cause LQTS would affect the clinical management of families affected by the disease.