Bronchopulmonary Lavage in Man
Authors: JOSE RAMIREZ-R.
Journal: Annals of Internal Medicine (1965)

Article1 November 1965Bronchopulmonary Lavage in ManJOSE RAMIREZ-R., M.D., RICHARD F. KIEFFER JR., M.D., WILMOT C. BALL JR., M.D.JOSE RAMIREZ-R., M.D., RICHARD F. KIEFFER JR., M.D., WILMOT C. BALL JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-819 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1963, it was postulated that some of the manifestations of pulmonary alveolar proteinosis resulted from an abnormality of the pulmonary clearing process (1, 2). Based on this concept, repeated pulmonary segmental flooding was introduced and successfully applied as a method of bronchiolo-alveolar debridement in the treatment of six cases of alveolar proteinosis (2-4). Subsequently, segmental infusion of therapeutic agents has been used in the treatment of other pulmonary diseases (5).Experience with these cases showed that segments of human lung could be irrigated four times a day with 50 to 100 ml of saline solution containing heparin, acetylcysteine, or...References1. RAMIREZ-R.NYKAMCLAUGHLIN JWJ: Pulmonary alveolar proteinosis. Diagnostic technics and observations. New Eng. J. Med. 268: 165, 1963. CrossrefMedlineGoogle Scholar2. RAMIREZ-R.SCHULTZDUTTON JRBRE: Pulmonary alveolar proteinosis: a new technique and rationale for treatment. Arch. Intern. Med. (Chicago) 112: 419, 1963. CrossrefMedlineGoogle Scholar3. MCLAUGHLINRAMIREZ-R. JSJ: Pulmonary alveolar proteinosis. Treatment by pulmonary segmental flooding. Amer. Rev. Resp. Dis. 89: 745, 1964. MedlineGoogle Scholar4. RAMIREZ-R.CAMPBELL JGD: Pulmonary alveolar proteinosis: endobronchial treatment. Ann. Intern. Med. 63: 429, 1965. LinkGoogle Scholar5. RAMIREZ-R. J: Pulmonary aspergilloma. Endobronchial treatment. New Eng. J. Med. 271: 1281, 1964. CrossrefMedlineGoogle Scholar6. CLEMENTS JA: Surface phenomena in relation to pulmonary function. 6th Bowditch Lecture. Physiologist 5: 11, 1962. MedlineGoogle Scholar7. SEVERINGHAUSBRADLEY JWAF: Electrodes for blood pO2 and pCO2 determinations. J. Appl. Physiol. 13: 515, 1958. CrossrefMedlineGoogle Scholar8. BATESBAUCOTDORMER DVNGAE: The pulmonary diffusing capacity in normal subjects. J. Physiol. (London) 129: 237, 1955. CrossrefGoogle Scholar9. WAGNERSABISTONMCAFEETOWSTERN HNDCJGDHS: Diagnosis of massive pulmonary embolism in man by radioisotope scanning. New Eng. J. Med. 271: 377, 1964. CrossrefMedlineGoogle Scholar10. CARLENS E: A new flexible double-lumen catheter for bronchospirometry. J. Thorac. Surg. 18: 742, 1949. CrossrefMedlineGoogle Scholar11. CORYLLOSBIRNBAUM PNGL: Studies in pulmonary gas absorption in bronchial obstruction. II. The behavior and absorption times of oxygen, carbon dioxide, nitrogen, hydrogen, helium, ethylene, nitrous oxid, ethyl chlorid, and ether in the lung. Amer. J. Med. Sci. 183: 326, 1932. CrossrefGoogle Scholar12. GROSSHATCH PT: Pulmonary clearance: its mechanism and its relation to pulmonary disease. J. Occup. Med. 5: 191, 1963. MedlineGoogle Scholar13. BUCKLEYTUCKERTHORNESIEKER CEDHNAHO: Bronchiolectasis: the clinical syndrome and its relationship to chronic lung disease. Amer. J. Med. 38: 190, 1965. CrossrefMedlineGoogle Scholar14. VAN GEMERTKYLSTRAVAN NOUHUYSDEN OTTER AGJFG: Technique of lavage of the lung in dogs. Acta Physiol. Pharmacol. Neerl. 5: 445, 1957. MedlineGoogle Scholar15. KYLSTRA JA: Lavage of the lung. Acta Physiol. Pharmacol. Neerl. 7: 163, 1958. MedlineGoogle Scholar16. KYLSTRA JA: Lavage of the lung. II. Acta Physiol. Pharmacol. Neerl. 8: 326, 1959. MedlineGoogle Scholar17. KYLSTRA JA: Lavage of the lung. Trans. Amer. Soc. Artif. Intern. Organs 5: 23, 1959. Google Scholar18. KYLSTRA JA: Simplified technique of lavage of the lung. Results in dogs. Acta Physiol. Pharmacol. Neerl. 9: 225, 1960. MedlineGoogle Scholar19. DE BOER J: Evaluation of lung lavage as a therapeutic measure in uremia. Acta Physiol. Pharmacol. Neerl. 12: 345, 1963. MedlineGoogle Scholar20. SALISBURYBRIGGSHAMELCROSSRIEBEN PFJNNDCEPA: Pulmonary lavage: the use of lung, in situ, as an artificial kidney. Trans. Amer. Soc. Artif. Intern. Organs 5: 32, 1959. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, MarylandFrom the Medical and Surgical Services of the Veterans Administration Hospital and the Departments of Medicine and Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md.Requests for reprints should be addressed to Jose Ramirez-R., M.D., Veterans Administration Hospital, 3900 Loch Raven Blvd., Baltimore, Md. 21218. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGranulocyte–Macrophage Colony-Stimulating Factor Inhalation Therapy for Severe Pulmonary Alveolar ProteinosisTherapeutic effect of subcutaneous injection of low dose recombinant human granulocyte-macrophage colony-stimulating factor on pulmonary alveolar proteinosisWhole-lung Lavage and Pulmonary Alveolar Proteinosis: Review of Clinical and Patient-centered OutcomesInsights into Anesthetic Challenges of Whole Lung LavageWhole Lung LavagePulmonary alveolar proteinosis in adults: pathophysiology and clinical approachAutoimmune pulmonary alveolar proteinosis in an adolescent successfully treated with inhaled rhGM-CSF (molgramostim)Treatment of Pulmonary Alveolar ProteinosisStart-up first stage of ICU and post-ICU brain rehabilitation: from the experiences of an old clinicianWhole Lung Lavage Treatment of Chinese Patients with Autoimmune Pulmonary Alveolar ProteinosisTherapeutic Whole-Lung Lavage for Pulmonary Alveolar ProteinosisPulmonary alveolar proteinosis in a 10-year-old girl masquerading as tuberculosisPulmonary alveolar proteinosis: time to shift?A 3-Step Therapeutic Strategy for Severe Alveolar ProteinosisLa protéinose alvéolaire pulmonaireWhole lung lavage combined with Granulocyte-macrophage colony stimulating factor inhalation for an adult case of refractory pulmonary alveolar proteinosisAutoimmune pulmonary alveolar proteinosis: Clinical course and diagnostic criteriaWhole-Lung LavageAutoimmune pulmonary alveolar proteinosis: Treatment options in year 2013The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosisPulmonary alveolar proteinosis: diagnostic and therapeutic challengesIntraoperative use of a chest physiotherapy system during whole lung lavage for pulmonary alveolar proteinosisAnesthesia for Lung Lavage in Pediatric Patient with Pulmonary Alveolar ProteinosisTherapeutic role of terbutaline in a rat whole-lung lavage modelHOPE-BALWhole Lung LavageNeumonía lipoidea por aspiración accidental de queroseno en un «comedor de fuego»Therapy options in pulmonary alveolar proteinosisAlveolar proteinosis syndrome: pathogenesis, diagnosis, and managementSuccessful unilateral partial lung lavage in a child with pulmonary alveolar proteinosisLavagem pulmonar total – A propósito de quatro casos de proteinose alveolarLavagem pulmonar total – A propósito de quatro casos de proteinose alveolarPulmonary alveolar proteinosisProteinose alveolar pulmonar: série de quatro casosLavagem broncoalveolar**Desenvolvimento de texto que serviu de base à intervenção "Lavagem Broncoalveolar: o estado da arte", proferida no XXXII Congresso Brasileiro de Pneumologia e Tisiologia e III Congresso Luso-Brasileiro de Pneumologia, Baía, Novembro 2004Whole lung lavage in the treatment of pulmonary alveolar proteinosisPulmonary Alveolar ProteinosisPlasmapheresis, GM-CSF, and alveolar proteinosisTherapeutic Whole Lung LavageLung image changes during bronchopulmonary lavage estimated using transoesophageal echocardiographyPulmonary alveolar proteinosis: Step-by-step perioperative care of whole lung lavage procedureWHOLE LUNG LAVAGELavagem broncoalveolar. O estado da arte**Desenvolvimento de texto que serviu de base a Conferência proferida durante o XV Congresso de Pneumologia. Ofir. Novembro 1999Primary Pulmonary Alveolar Proteinosis: A Case Report and a Review of the LiteratureOne-lung flooding for video-assisted thoracoscopic surgery in animal experiments on pigs — oxygenation and intrapulmonary shuntGuidelines of the Papanicolaou Society of Cytopathology for the Examination of Cytologic Specimens Obtained from the Respiratory TractBronchoalveolar and Serum Markers of Lung DiseaseLung flooding — a new method for complete lung sonographyValidity of pulmonary artery catheter-derived hemodynamic information during bronchopulmonary lavageLipoproteinosis alveolar tratada con lavado broncopulmonarThe role of bronchoalveolar lavage in the diagnosis of bacterial pneumoniaBronchoalveolar lavage studies in children without parenchymal lung disease: Cellular constituents and protein levelsSuccessful treatment of diffuse lipoid pneumonitis with whole lung lavage.Effect of bronchopulmonary lavage on lung retention and clearance of particulate material in hamsters.Whole Lung Lavage for Pulmonary Alveolar Proteinosis Perioperative Nursing ImplicationsBronchoalveolar Lavage: Its Application in AsthmaHemodynamic changes during whole bronchoalveolar lavage in two cases of pulmonary alveolar proteinosisBronchoalveolar LavageFuture directions for bronchoalveolar lavageBronchopulmonary lavage: Effects on oxygenation and hemodynamicsUnsuccessful unilateral bronchopulmonary lavage for a patient with severe cystic fibrosisDiagnostic Value of Combined Bronchoalveolar Lavage and Transbronchial Lung BiopsyPulmonary alveolar proteinosis: Primary and secondary, a report of three casesExperimentelle unilaterale lungenlavage: Elektrolytkinetik an der alveolokapillären MembranAnatomical distribution of bronchoalveolar lavage fluid as assessed by digital subtraction radiography.Pulmonary Alveolar Phospholipoproteinosis: Experience With 34 Cases and a ReviewProteinosis alveolar. Nula respuesta terapéutica a activadores del surfactante (ambroxol)Effet d'une pression expiratoire positive sur l'oxygénation artérielle en cours de lavage bronchoalvéolaire pour protéinoseTotal lung lavage for pulmonary alveolar proteinosis in an infant without the use of cardiopulmonary bypassTension ball valve mucus plug in asthmaBronchoalveolar Lavage and Transbronchial Biopsy for the Diagnosis of Pulmonary Infections in the Acquired Immunodeficiency SyndromeCOURTNEY BROADDUS, M.D., MICHAEL D. DAKE, M.D., MICHAEL S. STULBARG, M.D., WALTER BLUMENFELD, M.D., W. KEITH HADLEY, M.D., JEFFREY A. GOLDEN, M.D., PHILIP C. HOPEWELL, M.D.Proteinosis alveolar: a proposito de tres observacionesPulmonary alveolar proteinosis: prospective clinical experience in 23 patients for 15 yearsRespiratory tract fluids: Analysis of content and contemporary use in understanding lung diseasesGlycosaminoglycans and glycoproteins in bronchoalveolar lavage fluid from patients with pulmonary alveolar proteinosisRapid Diagnosis of Legionnaires' Disease by Bronchoalveolar LavageBilateral Simultaneous Lung Lavage Utilizing Membrane Oxygenator for Pulmonary Alveolar Proteinosis in an 8-Month-Old InfantTechnical Aspects of Bronchopulmonary Lavage for Alveolar Proteinosis: Two Case ReportsBronchopulmonary Lavage in Alveolar MicrolithiasisExperimental Unilateral Lung Flooding: A Morphological and Ultrastractural StudyBronchoalveolar lavage in pulmonary fibrosis: comparison of cells obtained with lung biopsy and clinical featuresThe Role of Mesna in the Treatment of Status Asthmaticus in ChildrenThe kinetics of macrophage and surfactant replacement in hamster lung following bronchopulmonary lavageChanges in Ventilation and Perfusion in Anesthetized Dogs following Lobar Lavage with Saline SolutionDiagnosis of Pneumonia due to Pneumocystis by Subsegmental Pulmonary Lavage via the Fiberoptic BronchoscopeRole of the Fiberoptic Bronchoscope in Lung Lavage of Patients with Cystic FibrosisPulmonary alveolar proteinosis: Analysis of pulmonary washingsThe Clinical and Physiological Effect of Whole-Lung Lavage in Pulmonary Alveolar Proteinosis: A Ten-Year ExperiencePulmonary Lavage in Patients Treated with Mechanical VentilationComparison of Three Techniques of Lung Lavage in Patients with Cystic FibrosisValidation of Therapeutic Bronchoscopic Bronchial Washing in Cystic FibrosisBronchopulmonary Lavage to Remove Pulmonary Casts and PlugsAlveolar lavage cytology in transplanted lungs I. Staining methods and findings in dogs with autografts and allografts without immunosuppressionAlveolar lavage cytology as a method for diagnosis of early rejection of transplanted lungsBronchoalveoläre Spülung zur Therapie der AlveolarproteinoseFailure of Bronchopulmonary Lavage in Cystic FibrosisLobar Lavage: Therapeutic Benefit in Pulmonary Alveolar Filling DisordersFunctional Morphology of the Distal LungBronchoscopy and bronchial lavage (BBL) in children with cystic fibrosisPulmonary alveolar microlithiasis in two siblings from IraqHemodynamic Response of the Pulmonary Circulation to Bronchopulmonary Lavage in ManSevere AsthmaPulmonary Alveolar ProteinosisBronchial lavage in asthma.Bronchopulmonary Lavage: A "New" Approach to Old ProblemsRespiratory FailureIl laboratorio di immunopatologia polmonarePulmonary alveolar proteinosisBronchial LavagePulmonary alveolar proteinosisMorphological and lipid analysis of the alveolar lining material in dog lungLung lavage (alveolar washing) in alveolar proteinosisOXYGENATION, INTUBATION AND VENTILATION IN ACUTE RESPIRATORY FAILUREBronchopulmonary Lavage in Normal Subjects and Patients with Obstructive Lung DiseaseT. N. FINLEY, M.D., E. W. SWENSON, M.D., W. S. CURRAN, M.D., G. L. HUBER, M.D., A. J. LADMAN, PH.D.Chronic disseminated alveolar diseases of the lungBronchopulmonary LavageTracheobronchial Lavage 1 November 1965Volume 63, Issue 5Page: 819-828KeywordsChronic bronchitisFloodingHeparinHospital medicineIsotonicityLungsProteinsPulmonary diseasesSaline solutionsSurgery Issue Published: 1 November 1965 PDF DownloadLoading ...