tbuckley/cabot-search huggingface dataset:
Granulomatous hypersensitivity to protamine as a complication of insulin therapy
Authors: M.M. HULSHOF, W.R. FABER, W.F. KNIESTEDT, M.J. BOEREE, P. KREEK
Journal: British Journal of Dermatology (1992)

Journal Article Granulomatous hypersensitivity to protamine as a complication of insulin therapy Get access M.M. HULSHOF, M.M. HULSHOF Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar W.R. FABER, W.R. FABER Departments of Dermatology Dr W.R. Faber, Eemland Hospital, Location De Lichtenberg, Department of Dermatology, Utrechtseweg 160, 3818 ES Amersfoort, The Netherlands. Search for other works by this author on: Oxford Academic Google Scholar W.F. KNIESTEDT, W.F. KNIESTEDT Departments of Pathology Search for other works by this author on: Oxford Academic Google Scholar M.J. BOEREE, M.J. BOEREE Internal Medicine, Eemland Hospital, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar P. KREEK P. KREEK Internal Medicine, Eemland Hospital, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 3, 1 September 1992, Pages 286–288, https://doi.org/10.1111/j.1365-2133.1992.tb00130.x Published: 01 September 1992
Was It Beri-beri?
Authors: Albert S. Ashmead
Journal: JAMA (1903)

New York, Jan. 10, 1903. <h3>To the Editor:</h3> —For the information of Dr. Frank Fenwick Young, whose interesting experiences with "Beri-beri in Louisiana" you have published inThe Journal, kindly print the fact that beri-beri has been found on ships reaching this port, all with carbon-producing cargoes (sugar, graphite, burnt Java coffee, etc.), whose crews had as their dietary<i>no rice at all</i>for the entire voyage. Dr. Judson Daland also found such an outbreak of beri-beri, on a sugar ship, too, which reached Philadelphia, whose crew were Lascars; that is, pork eaters. In an interesting investigation which I made many years ago with Col. John Screven of Savannah, Ga., the largest rice grower in the world, we found no beri-beri in those connected with the culture of rice, but plenty of malarial rheumatism (multiple neuritis, perhaps,) in those who did not take proper precautions while cultivating the flooded grounds.
Annual health checks for people with intellectual disabilities
Authors: M. Hoghton, G. Martin, U. Chauhan
Journal: BMJ (2012)

Potentially an important step towards reducing health inequalities

The recent convictions in the United Kingdom of 11 staff members from Winterbourne View Hospital of the criminal charges of abuse of adults with intellectual disabilities highlights the continued institutional weaknesses in caring for this vulnerable group.1 However, most people with intellectual disabilities reside in the community, supported by primary care services. Substantial effort has been made in recent years to improve the care of these people through a change in legislation and financial incentives to general practitioners.

In 2006 the Disability Rights Commission recommended the introduction of annual health checks for people with intellectual disabilities in England as a way to reduce the health inequalities experienced by this group.2 Since 2008 general practitioners in England have been incentivised to perform a structured annual health check for adults with intellectual disability through an optional payment process (enhanced service). 

The Learning Disabilities Public Health Observatory was set up in 2010 in response to a recommendation of the report of the Independent Inquiry into Access to Healthcare for People with Intellectual Disabilities.3 …
Myocardial Infarction in Women Younger Than 50 Years-Reply
Authors: Lynn Rosenberg
Journal: JAMA (1985)

In Reply.—  In our data, 1 the risk of nonfatal myocardial infarction for women who quit smoking is similar to that of women who never smoked, in agreement with the results of many other studies. 2,3 This finding is incompatible with Dr Burch's predisposition argument, unless one assumes that smokers who quit are not constitutionally predisposed to myocardial infarction while smokers who continue are so predisposed.
Association between bacterial vaginosis or chlamydial infection and miscarriage before 16 weeks' gestation: prospective community based cohort study
Authors: Pippa Oakeshott, Phillip Hay, Sima Hay, Frances Steinke, Elizabeth Rink, Sally Kerry
Journal: BMJ (2002)

<h3>Abstract</h3> <b>Objectives:</b> To assess whether bacterial vaginosis or chlamydial infection before 10 weeks9 gestation is associated with miscarriage before 16 weeks. <b>Design:</b> Prospective cohort study. <b>Setting:</b> 32 general practices and five family planning clinics in south London. <b>Participants:</b> 1216 pregnant women, mean age 31, presenting before 10 weeks9 gestation. <b>Main outcome measure:</b> Prevalence of miscarriage before 16 weeks9 gestation. <b>Results:</b> 121 of 1214 women (10.0%, 95% confidence interval 8.3% to 11.7%) miscarried before 16 weeks. 174 of 1201 women (14.5%, 12.5% to 16.5%) had bacterial vaginosis. Compared with women who were negative for bacterial vaginosis those who were positive had a relative risk of miscarriage before 16 weeks9 gestation of 1.2 (0.7 to 1.9). Bacterial vaginosis was, however, associated with miscarriage in the second trimester at 13-15 weeks (3.5, 1.2 to 10.3). Only 29 women (2.4%, 1.5% to 3.3%) had chlamydial infection, of whom one miscarried (0.32, 0.04 to 2.30). <b>Conclusion:</b> Bacterial vaginosis is not strongly predictive of early miscarriage but may be a predictor after 13 weeks9 gestation. The prevalence of <i>Chlamydia</i> was too low to assess the risk, but it is unlikely to be a major risk factor in pregnant women.
Abstract 1193: Guanylate binding protein-1, a novel oncogenic gene in glioblastoma
Authors: Ming Li, Webster Cavenee, Frank Furnari
Journal: Cancer Research (2011)

Abstract Glioblastoma multiforme (GBM) is the most common and deadly primary malignant brain tumor in adults. The most frequent genetic lesion associated with GBM, found at 40-60% frequency, is amplification and mutation of the EGFR gene. Here we report that guanylate binding protein-1 (GBP1), an immune response large GTPase, is involved in EGFR-mediated glioblatoma invasion through the modulation of matrix metallopeptidase-1 (MMP1) expression and show that GBP1 is upregulated in human GBM tumors relative to normal brain tissues, especially in EGFRvIII-positive samples. We further show that EGFRvIII promotes GBP1 expression at the transcriptional level through stimulation of the p38 MAPK signaling pathway and targeting GBP1 by lentivirus shRNA transduction significantly reduces EGFRvIII-mediated tumorigenicity of orthotopic xenografts in the mouse. Reciprocally, overexpression of GBP1 alone in glioma cells was sufficient to enhance glioma tumorigenesis by increasing cell proliferation, angiogenesis and decreasing cell apoptosis. Taken together, these results reveal that GBP1 is a novel oncogenic gene downstream of EGFRvIII signaling and suggest that GBP1 may serve as a promising therapeutic target for the treatment of GBM patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1193. doi:10.1158/1538-7445.AM2011-1193
DYSPEPSIA IN ELDERLY INDIVIDUALS.
Authors: JAMES S. McLESTER
Journal: JAMA (1906)

A large number—I had almost said the largest number—of our errors are those of omission. It is of a very common error of omission that I wish to speak. Optimism is ordinarily a virtue, but when carried too far it becomes failing. It is characteristic of most of us in the consideration of the various possibilities surrounding the complaining individual who consults us that we give first thought to the minor ailments which he may have and in a falsely optimistic manner leave from our consideration all thought of the graver diseases. Reflection will, I am sure, convince any one of the fallacy of this mental attitude; for where there are conditions making possible any of several disorders certainly we should endeavor, first of all, to exclude by all the means of our power the most serious of these, and then take into consideration the least serious. In passing, I
The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation
Authors: Antje M. Wengner, Simon C. Pitchford, Rebecca C. Furze, Sara M. Rankin
Journal: Blood (2007)

In this study, we have identified a unique combinatorial effect of the chemokines KC/MIP-2 and the cytokine granulocyte colony-stimulating factor (G-CSF) with respect to the rapid mobilization of neutrophils from the bone marrow in a model of acute peritonitis. At 2 hours following an intraperitoneal injection of thioglycollate, there was a 4.5-fold increase in blood neutrophil numbers, which was inhibited 84% and 72% by prior administration of blocking mAbs against either the chemokines KC/MIP-2 or G-CSF, respectively. An intraperitoneal injection of G-CSF acted remotely to stimulate neutrophil mobilization, but did not elicit recruitment into the peritoneum. Further, in vitro G-CSF was neither chemotactic nor chemokinetic for murine neutrophils, and had no priming effect on chemotaxis stimulated by chemokines. Here, we show that, in vitro and in vivo, G-CSF induces neutrophil mobilization by disrupting their SDF-1alpha-mediated retention in the bone marrow. Using an in situ perfusion system of the mouse femoral bone marrow to directly assess mobilization, KC and G-CSF mobilized 6.8 x 10(6) and 5.4 x 10(6) neutrophils, respectively, while the infusion of KC and G-CSF together mobilized 19.5 x 10(6) neutrophils, indicating that these factors act cooperatively with respect to neutrophil mobilization.
OT3-01-05: PARP Inhibition after Preoperative Chemotherapy in Patients with Triple-Negative Breast Cancer (TNBC) or Known BRCA 1/2 Mutations: Hoosier Oncology Group BRE09-146.
Authors: KD Miller, SM Perkins, SS Badve, GW Sledge, BP Schneider
Journal: Cancer Research (2011)

Abstract Background Based on recently reported I-SPY trial, TNBC patients who had residual disease category II or III had 2-year disease free survival (DFS) of only ∼40% (J Clin Oncol 2009;27:18s). Currently, no standard systemic therapy exists for this high-risk group. It represents a real opportunity to explore the potential impact of novel therapies. Recent laboratory and early clinical studies (Nature 2005;434:913) identified a unique sensitivity to DNA-damaging chemotherapy and PARP inhibition. We initiated a randomized phase II trial of DNA-damaging chemotherapy (cisplatin) or PARP-inhibition + cisplatin in TNBC patients with substantial residual invasive disease after standard anthracycline and/or taxane containing neoadjuvant chemotherapy. Methods: To ensure a high-risk population, patients must have residual disease category 0–2 based on the Miller-Payne classification system, residual cancer burden classification II or III, residual lymph node involvement, or at least 2 cm of residual invasive disease in the breast. After completion of standard radiation therapy (when indicated), patients are randomized 1:1 to cisplatin (75 mg/M2 IV Day 1 every 3 weeks x 4 cycles) alone or in combination with PARP inhibition (PF-01367338 — 24 mg IV D1, 2, 3 of each 3 week cycle with a single dose escalation to 30 mg in the absence of significant toxicity in cycle 1 followed by maintenance PARP inhibition weekly x 24 weeks). The primary objective is 2-year DFS. To detect an improvement in 2-year DFS from 40% with cisplatin alone to 63.2% in the cisplatin + PF-01367338 arm (corresponding to HR=0.5), with 80% power using a one-side log-rank test with 0.10 level of significance, 102 patients are required in the primary analysis. Secondary objectives include safety, 1-year DFS, overall survival, and biomarkers of tumor recurrence, resistance to chemotherapy and/or PARP inhibition. Two dose escalation safety cohorts (N=13) were completed without dose limiting toxicity; the randomized portion began enrolment in 11/2010 has enrolled 20 patients as of 05/2011. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr OT3-01-05.
Myocardial function and transmural blood flow during coronary venous retroperfusion in pigs.
Authors: B H Oh, M Volpini, M Kambayashi, K Murata, H A Rockman, G S Kassab, J Ross
Journal: Circulation (1992)

BACKGROUND The degree of recovery of regional myocardial contraction during coronary venous retroperfusion has not been well established, particularly in the absence of coronary collateral channels. Therefore, the maximal functional benefit attainable with coronary venous retroperfusion was assessed in pigs by means of using selective pump retroperfusion of the left anterior descending vein, with venting of the left anterior descending artery to zero pressure. METHODS AND RESULTS In eight anesthetized open-chest pigs during selective left anterior descending venous retroperfusion over a range of retroperfusion flows, regional myocardial function (percent systolic wall thickening by sonomicrometry) increased progressively to an average of 62% of control values at a retroperfusion flow rate 200% of control arterial flow. Progressive thickening of the end-diastolic dimension of the anterior wall was observed with increasing retroperfusion flow (from 8.7 +/- 0.9 to 10.7 +/- 2.3 mm, p less than 0.001). Perfusion pressures within the left anterior descending vein increased linearly with increased retroperfusion flow rates (up to 132 +/- 57 mm Hg with retroperfusion flow 200% of control). A gradual increase of retrograde left anterior descending arterial outflow was observed with increasing retroperfusion flows; however, the absolute amount (maximum, 8.3 +/- 4.1 ml/min) was much too low to explain the extent of functional recovery. Transmural myocardial capillary blood flows in the anterior wall with retroperfusion flows of 100% and 200% of control arterial flow were 0.22 and 0.42 ml/min/g with corresponding subendocardial blood flows of 0.14 and 0.29 ml/min/g; ratios of endocardium to epicardium were 0.51 and 0.61, respectively. Thus, capillary blood flows during selective retroperfusion were relatively low despite considerable restoration of regional systolic wall thickening, and a significant difference was noted in the slopes of the relations between regional systolic wall thickening and myocardial blood flow during retroperfusion and anterograde arterial perfusion (p less than 0.05). With retrograde injection of silicone elastomer at different retroperfusion pressures (50, 75, and 100 mm Hg) in three pigs, capillaries were well visualized, and profuse intramyocardial venous anastomotic connections were seen at the highest retroperfusion pressure (100 mm Hg), whereas there was filling of small venules but little capillary filling at the lowest retroperfusion pressure (50 mm Hg). CONCLUSIONS Considerable recovery of regional myocardial function with low regional capillary blood flows were observed during acute venous retroperfusion with high retroperfusion flows with arterial blood. These findings together with low levels of retrograde arterial outflow and visualization of retrograde capillary filling with a rich venous network provide evidence for possible oxygen delivery via the intramyocardial venous plexus.
SEMI-QUANTITATIVE EVALUATION OF CSF FLOW BY WHOLE-BODY IMAGING IN CANCER PATIENTS WITH LEPTOMENINGEAL CARCINOMATOSIS
Authors: F. C. Wong, K. Jaeckle, E. E. Kim, D. Macey, S. McCullough, D. A. Podoloff
Journal: Clinical Nuclear Medicine (1998)

Wong, F. C.; Jaeckle, K.; Kim, E. E.; Macey, D.; McCullough, S.; Podoloff, D. A. Author Information
Trends in blood pressure over 10 years in adolescents: analyses of cross sectional surveys in the Northern Ireland Young Hearts project
Authors: David Watkins, Peter McCarron, Liam Murray, Gordon Cran, Colin Boreham, Paula Robson, Claire McGartland, George Davey Smith, Maurice Savage
Journal: BMJ (2004)

<h3>Abstract</h3> <b>Objective</b> To examine secular trends in blood pressure over a 10 year period between two representative cohorts of adolescents from Northern Ireland. <b>Design</b> Repeat cross sectional study. <b>Setting</b> Randomly selected post-primary schools from Northern Ireland. <b>Participants</b> 1015 adolescents studied between 1989 and 1990, and 2017 adolescents studied between 1999 and 2001. Participants were aged 12 or 15 years. <b>Main outcome measures</b> Systolic and diastolic blood pressure measured by one observer in each study. <b>Results</b> The four groups for sex and age showed decreases in both systolic blood pressure (mean decrease 7.7 mm Hg to 10.0 mm Hg) and diastolic blood pressure (8.8 mm Hg to 11.0 mm Hg). These decreases were not accounted for by adjustment for potential confounders including age, height, body mass index, smoking, physical activity, aerobic fitness, and stratification of school by education board area and type. The findings were not altered by additional adjustment for social class, pubertal status, birth weight, and infant feeding. No evidence was found of systematic variation between observers. <b>Conclusions</b> Substantial decreases in systolic and diastolic blood pressure over the past decade in adolescents from Northern Ireland are likely to have important benefits to public health and may help offset the increasing risk of cardiovascular disease due to increases in obesity.
Skin fragility and blistering due to use of sunbeds
Authors: P M Farr, J. M Marks, B L Diffey, P Ince
Journal: BMJ (1988)

Polyp counts during operation and at follow up. CommentBussey et al have studied the reliability of polyp counting with particular reference to the variation between two observers.4They reported counts by different observers to vary by not more than 27%.In the present study a standardised technique and, in most cases, the same observer were used to minimise even this variation.Allowing for a 30% error in the number of polyps recorded for any pair of observations, the counts obtained in our patients still show a significant decrease.Many factors have been suggested to account for the regression of polyps.They include a decrease in the pH of the faecal stream, a reduced rectal blood supply, and the removal of a colonic "stimulating factor."The relation between regression and the development of carcinoma is interesting.It cannot be said that an absence of rectal polyps provides complete protection against carcinogenesis.Several cases of carcinoma in patients who do not have polyps have been recorded.'The question of whether repeated trauma from fulguration or biopsy may be a precipitating factor has been raised.Cancer of the rectum has not been seen in patients who undergo spontaneous regression.'Some patients who undergo regression subsequently develop further adenomas, mainly at the site of anastomosis.Regression of polyps does not reduce the necessity for a policy of intensive surveillance.I Hubbard TIB.Familial polvposis of the colon: the fate oft the retained rectum after colectomy in
858. Adeno-Associated Virus Vector Serotype 8 (AAV8) Achieves a Higher Level of Gene Transfer to the Central Nervous System (CNS) upon Intraventricular Injection in Neonatal Mice Compared to AAV1 and AAV2
Authors: Marike Broekman, Fabricio Costa, Comer Laryssa, LeRoy Stan, Sena Esteves Miquel
Journal: Molecular Therapy (2005)

Top of pageAbstract
Adeno-associated virus (AAV) vectors are very promising in gene therapy of genetic diseases of the central nervous system (CNS). Thusfar, different AAV serotypes accomplished widespread gene delivery to the CNS. Moreover, they transduced different structures and cell types within the CNS. Recently, DNA spanning entire rep-cap ORF from a novel AAV serotype, AAV8, was isolated. This raises the interesting question whether AAV-8 can be used for gene therapy of genetic diseases of the CNS.

In this study, we compared the tropisms and transduction efficiencies of AAV-8, AAV-1, and AAV-2 within the mouse central nervous system (CNS).

We injected 2 |[mu]|l of AAV serotypes 1,2, and 8 (encoding GFP under control of the CBA promoter) with titers of 1.7 1013 into each cerebral lateral ventricle of neonatal C57BL6 mice at the day of birth. The mice were sacrificed at 1 month post-injection. We analyzed the mouse brains for GFP-expression by epifluorescence of frozen sections. Phenotyping of transduced cells was performed by NeuN immunofluorescence of frozen sections.

We found that all serotypes are capable of widespread distribution of large numbers of vector transduced cells in the CNS.

We did, however, observe major differences in the tropisms and transduction efficiencies of the different serotypes. AAV-8 transduced the cortex more efficiently than AAV-1 and AAV-2. Moreover, AAV-8 appears to transduce different layers of the cortex, contrary to AAV-1, which transduction appears to be more restricted.

Although AAV-2, contrary to AAV-1, transduced the striatum, our data suggests that AAV-8 is able to transduce the striatum even more efficiently.

Even though the exact amounts of transduced cells still have to be quantified by stereology, our data strongly suggests that the number of GFP expressing cells in the CA1 en CA3 regions of the hippocampus is much higher in the brains injected with AAV-8 than in the brains injected with AAV-1 and AAV-2.

Besides that, our data strongly suggests that AAV-8 has not only the capacity to efficiently transduce different structures of the CNS but also the capacity to transduce different cell types.

In conclusion, intraventricular injection of neonatal mice with AAV-8 results in widespread delivery of GFP to the CNS. Moreover, AAV-8 transduces a higher number of (different) cells and different structures of the CNS compared to AAV-1 and AAV-2.