Sex Differences in Long-Term Mortality after Myocardial Infarction
Authors: J. Carlos Ayus, Allen I. Arieff
Journal: Annals of Internal Medicine (2001)

Letters18 December 2001Sex Differences in Long-Term Mortality after Myocardial InfarctionJ. Carlos Ayus, MD and Allen I. Arieff, MDJ. Carlos Ayus, MDBaylor College of Medicine; Houston, TX 77019University of California, San Francisco; Sausalito, CA 94965-2530Search for more papers by this author and Allen I. Arieff, MDBaylor College of Medicine; Houston, TX 77019University of California, San Francisco; Sausalito, CA 94965-2530Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-12-200112180-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with great interest the article by Vaccarino and colleagues concerning the increased mortality rate associated with myocardial infarction in younger women (1). The mortality rate in women was significantly higher than that in men (20.9% vs. 13.6%), and among patients younger than 50 years of age, the risk for death was three times higher in women than in men. After analysis for numerous demographic and clinical characteristics, as well as cardiac therapy during hospitalization, the authors found no obvious answer to explain the increased mortality rate in young women. They suggested several possible mechanisms, including ...References1. Vaccarino V, Krumholz HM, Yarzebski J, Gore JM, Goldberg RJ. Sex differences in 2-year mortality after hospital discharge for myocardial infarction. Ann Intern Med. 2001;134:173-81. [PMID: 11177329] LinkGoogle Scholar2. Cushman M, Legault C, Barrett-Connor E, Stefanick ML, Kessler C, Judd HL, et al . Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study. Circulation. 1999;100:717-22. [PMID: 10449693] CrossrefMedlineGoogle Scholar3. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836-43. [PMID: 10733371] CrossrefMedlineGoogle Scholar4. Kozniewska E, Roberts TP, Vexler ZS, Oseka M, Kucharczyk J, Arieff AI. Hormonal dependence of the effects of metabolic encephalopathy on cerebral perfusion and oxygen utilization in the rat. Circ Res. 1995;76:551-8. [PMID: 7895330] CrossrefMedlineGoogle Scholar5. Ayus JC, Wheeler JM, Arieff AI. Postoperative hyponatremic encephalopathy in menstruant women. Ann Intern Med. 1992;117:891-7. [PMID: 1443949] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine; Houston, TX 77019University of California, San Francisco; Sausalito, CA 94965-2530 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSex Differences in 2-Year Mortality after Hospital Discharge for Myocardial Infarction Viola Vaccarino , Harlan M. Krumholz , Jorge Yarzebski , Joel M. Gore , and Robert J. Goldberg Sex Differences in Long-Term Mortality after Myocardial Infarction Kathleen Franco-Bronson , Marijo Tamburrino , and Nicolle McGowan Sex Differences in Long-Term Mortality after Myocardial Infarction Ernest H. Friedman Sex Differences in Long-Term Mortality after Myocardial Infarction Viola Vaccarino and Robert J. Goldberg Metrics Cited ByNeurobiology of atypical presentations among medicare beneficiaries with unstable angina pectorisWomen's Health LiteratureWatch 18 December 2001Volume 135, Issue 12Page: 1089KeywordsAntidiuretic hormoneBlood flowBlood plasmaBrainC-reactive proteinsDeath ratesEstrogensMyocardial infarctionOxygenVasoconstriction ePublished: 18 December 2001 Issue Published: 18 December 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...