The Integrated Gonadotrophin Test
Authors: STEVEN J. SANTNER
Journal: Annals of Internal Medicine (1978)

Brief Reports1 October 1978The Integrated Gonadotrophin TestSTEVEN J. SANTNER, B.S., FREDERICK T. MURRAY, M.D., BONNIE DAVIS, B.S., RICHARD J. SANTEN, M.D., F.A.C.P.STEVEN J. SANTNER, B.S.Search for more papers by this author, FREDERICK T. MURRAY, M.D.Search for more papers by this author, BONNIE DAVIS, B.S.Search for more papers by this author, RICHARD J. SANTEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-512 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pulsatile nature of luteinzing hormone (LH) and, to a lesser extent, follicle-stimulating hormone (FSH) secretion requires that integrated gonadotrophin concentrations be ascertained to accurately assess gonadotrophin status in patients (1-4). Measurements of LH and FSH in precisely timed 3-to-24 h urine collections (5-6) or in serial blood samples during 3-to-6 h (2, 7) are effective means of integrating pulsatile gonadotrophin fluctuations. However, these methods are expensive because urine requires extraction and concentration before radioimmunoassay and serial blood sampling generates a large number of specimens to be run individually. When dynamic testing with luteinzing hormone-releasing hormone (LH-RH) or clomiphene is...References1. MIDGLEYJAFFE AR: Regulation of human gonadotropins: X. Episodic fluctuation of LH during the menstrual cycle. J. Clin Endocrinol Metab 33:962-969, 1971 CrossrefMedlineGoogle Scholar2. SANTENBARDIN RC: Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms. J Clin Invest 52:2617-2628, 1973 CrossrefMedlineGoogle Scholar3. YENTSAINAFTOLINVANDENBERGAJABOR SCFGL: Pulsatile patterns of gonadotropin release in subjects with and without ovarian function. J Clin Endocrinol Metab 34:671-675, 1972 CrossrefMedlineGoogle Scholar4. NANKINTROEN HP: Repetitive luteinizing hormone elevations in serum of normal men. J Clin Endocrinol Metab 33:558-560, 1971 CrossrefMedlineGoogle Scholar5. KULINBELLSANTENFERBER HPRA: Integration of pulsatile gonadotropin secretion by timed urinary measurements: an accurate and sensitive 3-hour test. J Clin Endocrinol Metab 40:783-789, 1975 CrossrefMedlineGoogle Scholar6. KULINSANTNER HS: Timed urinary gonadotropin measurements in normal infants, children, and adults, and in patients with disorders of sexual maturation. J Pediatr 90:760-765, 1977 CrossrefMedlineGoogle Scholar7. GOLDZIEHERDOZIERSMITHSTEINBERGER JTKE: Improving the diagnostic reliability of rapidly fluctuating plasma hormone levels by optimized multiple-sampling techniques. J Clin Endocrinol Metab 43:824-830, 1976 CrossrefMedlineGoogle Scholar8. SANTENLEONARDSHERINSGANDYPAULSEN RJRHC: Short- and long-term effects of clomiphene citrate on the pituitary-testicular axis. J Clin Endocrinol Metab 33:970-979, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Milton S. Hershey Medical Center The Pennsylvania State University Hershey, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1978Volume 89, Issue 4Page: 512-513KeywordsAttentionBloodFollicle stimulating hormoneFollicle-stimulating hormoneHormonesLuteinizing hormoneRadioimmunoassaysUrine Issue Published: 1 October 1978 PDF DownloadLoading ...