tbuckley/cabot-search huggingface dataset:
Phenylazopyridine (Pyridium®) and Acute Renal Failure
Authors: NAUMAN QURESHI
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 March 1979Phenylazopyridine (Pyridium®) and Acute Renal FailureNAUMAN QURESHI, M.D., ROBERT W. HEDGER, M.D.NAUMAN QURESHI, M.D.Search for more papers by this author, ROBERT W. HEDGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-443_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Pyridium® (phenylazopyridine) is a urinary-tract analgesic that can cause acute renal insufficiency in people with pre-existing renal damage. We report here the case history and renal biopsy of a young woman with normal renal status who ingested an overdose of phenylazopyridine and developed acute renal failure. The histologic findings are similar to autopsy findings previously described by Alano and Webster (1) in the January 1970 issue.A 20-year-old woman was admitted with a 3-day history of nausea and vomiting after ingesting a single 4-g dose of phenylazopyridine, with suicidal intentions. There was no history of yellow skin...References1. ALANO F and WEBSTER G: Acute renal failure and pigmentation due to phenylazopyridine (Pyridium®). Ann Intern Med 72:89-91, 1970 LinkGoogle Scholar2. GOULD S: Urinary tract disorders. Clinical comparison of flavoxate and phenylazopyridine. Urology 5:612-615, 1975 CrossrefMedlineGoogle Scholar3. GREENBERG M and WONG H: Methemoglobinemia and Heinz body hemolytic anemia due to phenylazopyridine hydrochloride. N Engl J Med 271:431-435, 1964 CrossrefMedlineGoogle Scholar4. HOOD J and TOTH W: Jaundice caused by phenylazopyridine hydrochloride. JAMA 198:1366-1367, 1966 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: NAUMAN QURESHI, M.D.; ROBERT W. HEDGER, M.D.Affiliations: Columbus Hospital and University of Illinois Abraham Lincoln School of Medicine Chicago, IL 60614 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhenazopyridine associated acute interstitial nephritis and review of literatureAcute renal failure due to phenazopyridine (Pyridium®) overdose: case report and review of the literatureTransient renal failure following phenazopyridine overdoseAcquired Acute Hemolytic Anemia Secondary to Phenazopyridine 1 March 1979Volume 90, Issue 3 Page: 443-443 Keywords Acute renal failure Analgesics Autopsy Biopsy Nausea Vomiting ePublished: 1 December 2008 Issue Published: 1 March 1979 PDF downloadLoading ...
THE PANCREAS AS AN ORGAN OF INTERNAL SECRETION
Authors: E. T. WATERS
Journal: JAMA (1941)

Removal of a dog's pancreas produces in that animal a series of metabolic changes which are strikingly similar to those of severe diabetes mellitus in human subjects. No less definite is the speedy elimination of these abnormalities in both the depancreatized dog and the patient with diabetes following the injection of insulin, which is obtained from normal pancreatic tissue. The observations on the effects of pancreatectomy, made by von Mering and Minkowski,1and those on the effect of insulin on depancreatized dogs, made by the group in the department of physiology of the University of Toronto,2provided very good evidence for the association of the pancreas and its internal secretion with the condition of diabetes. These salient facts have been added to extensively during the last few years. Some of the additions have established older views more definitely, whereas some have led to entirely new conceptions of the
Australia accused of blocking doctors visit to asylum seekers
Authors: C. Zinn
Journal: BMJ (2004)

The Australian government has been accused of pressuring a tiny Pacific Island nation to block the visit of an independent team of specialists to review the health conditions of asylum seekers held there.

The team was offered visas to Nauru after its head doctor, Kieren Keke, said the island's only hospital had struggled to cope with a 30 day hunger strike by up to 45 mainly Afghan asylum seekers who were detained trying to enter Australia.

The hunger strike was suspended recently after the Australian specialists announced plans to visit the island, …
Abuse of Medical Students
Authors: Kathleen Rawlins
Journal: JAMA (1990)

To the Editor. —  As a nurse with over 20 years in practice, I read with interest the article on  of medical students, 1 in particular the finding that personal abuse made medical students consider leaving their profession. Both medical and nursing students enter the clinical setting with a textbook perspective on medical therapy, lacking the wisdom of experience—to treat the whole patient, not just the disease. Unlike medical students, however, nurses begin bedside care within 6 months after starting classroom education. I contend that this early experience in the clinical setting, in addition to the holistic emphasis in nursing education, provides a less abusive, more positive experience for nurses (and therefore their patients) from which medical students would benefit.  Most medical students examine patients like laboratory specimens. They do not consider introducing themselves or explaining the examination, much less whether the patient is uncomfortable, frightened, or in pain.
TCT-718 Large Multicenter Assessment of SAPIEN 3 Transcatheter Aortic Valve Implantation: Optimization of Clinical Outcomes with Precise Device Positioning
Authors: Danny Dvir, Thomas Walther, David A. Wood, Matheus S. Santos, Riccardo Cocchieri, Jan Baan jr., Won-Keun Kim, John Webb
Journal: Journal of the American College of Cardiology (2014)
AIDS and the health professions
Authors: G Ayliffe, A Geddes, M Casewell, J Craske, B Gazzard, D C Shanson, V Hoffbrand, P Kernoff, W Brumfitt, D Jeffries, C T Keane, M Longson, A Percival, D S Reeves, G Ridgway, J Selkon, D C E Speller, R Weiss
Journal: BMJ (1985)
New Dietary Guidelines From the American Diabetes Association
Authors: Toni Irwin
Journal: Diabetes Care (2002)

Patients With Type 1 Diabetes1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] not only regulates calcium metabolism but also modulates the immune system.Some reports have suggested that 1,25(OH) 2 D 3 helps to prevent the development of type 1 diabetes.The association between the vitamin D receptor (VDR) genotype and susceptibility to type 1 diabetes has been examined, but a definitive conclusion has not yet been reached (1,2).We examined the VDR genotype in juvenile Japanese patients with type 1 diabetes.A total of 108 diabetic patients (41 boys and 67 girls, age of onset 0.4 -18 years with a median age of 8.9) and 120 nonrelated nondiabetic subjects were studied.Three polymorphic restriction fragment-length polymorphisms (RFLPs), i.e., Fok I, ApaI, and TaqI, were genotyped by PCR-RFLP method.The genotype or allele frequencies were compared statistically by the 2 test.The significance of differences in each genotype for the age of onset was tested with the Mann-Whitney U test.Among the patients, the FF (n ϭ 50) and tt (n ϭ 5) genotypes were found relatively frequently, and aa (n ϭ 46) was infrequent compared with those in control subjects, but these differences were not statistically significant (P ϭ 0.14, 0.18, and 0.38 for FF, tt, and aa genotypes, respectively).There was also no significant difference in the allele frequency of each polymorphism, although the incidence of the F allele tended to be higher in the diabetic patients (P ϭ 0.051).Concerning the age of onset of diabetes, patients with the ff genotype (n ϭ 12, median 5.2 years, range 1.7-11.0)were significantly younger at onset than those with FF (n ϭ 50, 9.7 years, 0.4 -15.9, P ϭ 0.01) or Ff (n ϭ 46, 8.9 years, 0.9 -18.0,P ϭ 0.03).No significant association was observed between the TaqI or ApaI genotype and the age of onset.The ff genotype has been reported to be associated with a lower expression of VDR mRNA and reduced inhibition of phytohemagglutinin-stimulated growth of peripheral blood mononuclear cells.Thus, the Fok I genotype may influence the rate of the progression of insulitis by modifying the autoimmune process, which may have led to the significant difference in the age of onset.The relatively high frequency of the F allele in diabetic patients, which has also been found in Japanese adult diabetic patients (2), is apparently inconsistent with this observation.A possible explanation is that the impact of Fok I polymorphism may not be strong enough to prevent the progression of autoimmune insulitis into overt diabetes and thus does not influence susceptibility to the disease itself.In conclusion, VDR gene polymorphism does not appear to have a strong enough impact to clearly influence susceptibility to the disease itself, but Fok I polymorphism might influence the age of onset of diabetes in juvenile Japanese diabetic patients.
Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia
Authors: Maaike C.G. Bleeker, Cornelis J.A. Hogewoning, Adriaan J.C. van den Brule, Feja J. Voorhorst, Rick E. van Andela, Elle K.J. Risse, Theo M. Starink, Chris J.L.M. Meijer
Journal: Journal of the American Academy of Dermatology (2002)
Measuring Children's Antisocial Behaviors
Authors: Terrie E. Moffitt
Journal: JAMA (1996)

In this issue ofThe Journal, Needleman and colleagues<sup>1</sup>report that elevated bone lead is associated with young boys' attention problems, aggression, and delinquency. Certainly the tibia does not deceive about its lead burden. But can we really expect boys to confess their transgressions truthfully? Skepticism is partially allayed because the research links lead and antisocial behavior using not only boys' reports, but also their teachers' and parents' reports. Nonetheless, one might challenge the study's measures of behavior problems. What are these measures? How accurate are they? Are they applicable to children beyond the study participants? Perhaps most important, do they predict behavior later in life? See also p 363. What are these measures? Needleman et al selected widely respected measures of children's antisocial behavior: the Child Behavior Checklist (CBCL)<sup>2</sup>for parents and teachers and the self-reported delinquency interview for the boys.<sup>3</sup>Parents and teachers selected items
Over-the-Counter Ibuprofen and Nephrotic Syndrome
Authors: FEDERICO R. JUSTINIANI
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Over-the-Counter Ibuprofen and Nephrotic SyndromeFEDERICO R. JUSTINIANI, M.D.FEDERICO R. JUSTINIANI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-303_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Interstitial nephritis associated with nephrotic syndrome has been identified as a complication of therapy with nonsteroidal anti-inflammatory drugs (1-4). Ibuprofen has only been reported once as the cause of this condition (5). I report the case of a patient who, after self-administration of over-the-counter ibuprofen, developed nephrotic syndrome without renal failure.A 56-year-old, white, morbidly obese, hypertensive businessman presented with a 2-week history of marked swelling of his legs and lower trunk. During the preceding 6 months, he had taken an average of eight tablets (1.6 g) daily of ibuprofen for pain in his knees. One month...References1. CLIVESTOFF DJ. Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N Engl J Med. 1984;310:563-72. CrossrefMedlineGoogle Scholar2. ABRAHAMKEANE PW. Glomerular and interstitial disease induced by nonsteroidal anti-inflammatory drugs. Am J Nephrol. 1984;4:1-6. CrossrefMedlineGoogle Scholar3. BLACKSHEARNAPIERDAVIDMANSTILLMAN JJMT. Renal complications of nonsteroidal anti-inflammatory drugs: identification and monitoring of those at risk. Semin Arthritis Rheum. 1985;14:163-75. CrossrefMedlineGoogle Scholar4. CARMICHAELSHANKEL JS. Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function. Am J Med. 1985;78:992-1000. CrossrefMedlineGoogle Scholar5. REGESTER R. Nephrotic syndrome and renal failure associated with use of nonsteroidal anti-inflammatory drugs. J Tenn Med Assoc. 1980;73:709-11. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mount Sinai Medical Center Miami Beach, FL 33140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIbuprofenKetoprofenAtteintes rénales graves au cours d’un traitement par anti-inflammatoires non stéroïdiens arylcarboxyliques : bilan d’une enquête nationale de pharmacovigilanceCase 36-2003Drugs and the KidneySouthwestern Internal Medicine Conference: Analgesic NephropathyAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 August 1986Volume 105, Issue 2Page: 303-303KeywordsDrug therapyIbuprofenInflammationKneesNephritisOverweightRenal failure Issue Published: 1 August 1986 PDF DownloadLoading ...
MEDEX—Five Years Later
Authors: Richard A. Smith
Journal: JAMA (1975)

<h3>To the Editor—</h3> Initiated in 1969 at the University of Washington School of Medicine, the MEDEX system of<i>training and deploying</i>physician extenders into areas of need has quietly surpassed all expectations. By having practicing physicians, medical associations, and medical faculties work closely in collaboration with the programs, the concept has produced nine medical school regional training centers that are training MEDEX students for 34 states. David Lawrence (MEDEX/Northwest in Seattle) and William Wilson (MEDEX/Utah) have submitted an article for publication that describes in addition: 92% of MEDEX graduates in the country are employed in full-time practice settings, most in the private sector, and 98% are in the field of medicine. Nearly 90% of MEDEX graduates are working with primary care physicians, most of whom (76%) are family physicians. Seventy percent of MEDEX graduates are employed in towns under 20,000 in size; most graduates are in towns of less than
P624Genetic disruption of the Rac inhibitor ArhGAP15 leads to aortic valve disease in mice
Authors: A Ghigo, J Cimino, M Li, F Morello, E Hirsch
Journal: Cardiovascular Research (2014)

Purpose: The Rac-GTPase activating protein ArhGAP15 negatively modulates the small GTPase Rac in leukocytes. We demonstrated previously that neutrophils lacking ArhGAP15 have enhanced chemotactic responses, straighter directional migration, amplified reactive oxygen specie production and increased bacterial phagocytosis. Given the central role of immune cell activation in cardiac diseases, we intend to investigate the impact of such an hyperactive immune system on cardiac pathophysiology. Methods: Echocardiography was performed to assess heart morphometry and function in 2, 4 and 6 month-old ArhGAP15 WT and KO male mice. Aortic valve structure and inflammation were assessed by H&E staining and immunohistochemistry. Results: Cardiac function and morphometry did not differ significantly between young WT and KO animals (2 months). Conversely, KO mice developed eccentric hypertrophy at 4 months of age as evidenced by a mild increase in heart weight to body weight ratio (HW/BW (mg/g) WT: 3.47±0.14; KO: 4.28±0.22; *P<0.05) and by left ventricle dilation (LVEDD (mm) WT: 3.27±0.17; KO: 3.95±0.11; ***P<0.001). The finding that cardiac output was 45% higher in KO than in WT hearts (CO (ml/min) WT: 12.53±0.47; KO: 21.45±2.29; **P<0.01) indicated that the left ventricle enlargement observed in KO mice was secondary to cardiac volume overload. In keeping with these findings, 40% of KO mice suffered from aortic regurgitation, a major cause of volume overload, and showed aortic valve malformations, including irregular size and thickening of valve leaflets, despite a normal three-leaflet structure. Intriguingly, the structural abnormalities of KO aortic valves were accompanied by enhanced recruitment of inflammatory cells as the number of CD18-positive infiltrating leukocytes was significantly higher than in WT tissues. Aortic valve dysfunction eventually led to systolic failure in aged, 6 month-old KO mice (FS (%) WT: 37.28±1.85; KO: 29.9±0.88; **P<0.01). Conclusion: Altogether, these findings demonstrate that genetic disruption of ArhGAP15 predisposes to cardiac valve disease and predict cardiovascular complications in recently described patients with ArhGAP15 genetic deletions.
ARTIFICIAL HYPEREMIA IN THE TREATMENT OF DELAYED UNION.Read before the Mahoning County Medical Society, April 9, 1894.
Authors: W. H. BUECHNER
Journal: JAMA (1894)

In 1875, Nicoladoni published an article upon Dumreicher's method of treating threatened pseudarthrosis. The underlying principle of the method was the production of hyperemia at the seat of fracture by means of compression above and below that point. The method demanded the use of graduated compresses, extra splints, etc., and was quite complicated. It does not seem to have come into general use, as Bruns says he only knows of five cases where it was successfully employed. H. O. Thomas, of Liverpool, recommends a similar method, combining with it, percussion. He endeavors to produce severe irritation at the seat of fracture by vigorous percussion—sometimes in anesthesia. After this he seeks to retain the congestion by elastic constriction above and below the part percussed. In a paper read before the German Surgical Society in 1887, Helferich proposed to employ artificial hyperemia, producedby elastic constriction, in the treatment not only of delayed
1, Adrenergic stimulation, calcium, and arrhythmias
Authors: G. GAMBASSI, P. CARBONIN
Journal: Cardiovascular Research (1993)

Journal Article α1, Adrenergic stimulation, calcium, and arrhythmias Get access GIOVANNI GAMBASSI, GIOVANNI GAMBASSI Istituto di Clinica Medica Generale, Università Cattolica del Sacro Cuore, Rome, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar PIERUGO CARBONIN PIERUGO CARBONIN Istituto di Clinica Medica Generale, Università Cattolica del Sacro Cuore, Rome, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 10, October 1993, Page 1886, https://doi.org/10.1093/cvr/27.10.1886 Published: 01 October 1993
Current issues in cancer. Biological therapy.
Authors: T. Perren, P. Selby
Journal: BMJ (1992)

BMJ 1992;304:1621-3 Biological therapy for cancer may be defined as a treatment that uses biological materials, usually cells or cell products, which either have direct effects on tumour cell proliferation or differentiation or modify the host biological response to the malignant disease.1 The subject has a long history, extending back to the last century when patients were treated with extracts of infectious organisms or tumours, with occasional success claimed. In the 1970s immunotherapy with BCG and allogeneic or autologous tumour cells was widely investigated, but carefully performed clinical studies failed to show consistent success. However, in the past few years there has been increasing interest in biological therapy for cancer and considerable research activity. In this article we will try to explain the reasons for the increasing current interest and try to discern whether there is really promise of progress.
Management of Advanced Prostate Cancer After First-Line Chemotherapy
Authors: Dominik R. Berthold, Cora N. Sternberg, Ian F. Tannock
Journal: Journal of Clinical Oncology (2005)

Hormone refractory prostate cancer (HRPC) causes substantial morbidity and mortality. There are increasing options for both first- and second-line therapy in the palliative treatment of patients with HRPC. Medications to control symptoms should first be optimized in patients with late-stage disease, and radiotherapy applied to dominant painful bone lesions. Docetaxel, mitoxantrone, satraplatin, and ixabepilone are active chemotherapeutic agents in the first- and/or second-line setting for patients with HRPC, and this may be true also of older drugs such as oral cyclophosphamide and vinorelbine. Radioisotopes such as strontium and samarium are useful for treatment of more generalized bone pain. Third-line hormonal maneuvers including glucocorticoids, ketoconazole, and estrogens can lead to further palliation in some patients, and there are provocative data that chemotherapy might restore hormonal sensitivity in a subset of patients.
Coexistence of paroxysmal nocturnal hemoglobinuria and chronic lymphocytic leukemia
Authors: George A. Omura
Journal: American Journal of Hematology (1981)

Abstract A man with paroxysmal nocturnal hemoglobinuria and a lymphoproliferative disorder is described. The latter condition evolved into a typical picture of chronic lymphocytic leukemia. The significance of this association is obscure, but treatment of one or the other disease was clearly not an etiologic factor in this concurrence.
Cholangiocarcinoma: Molecular targeting strategies for chemoprevention and therapy
Authors: Alphonse E. Sirica
Journal: Hepatology (2004)

Cholangiocarcinomas are devastating cancers that are increasing in both their worldwide incidence and mortality rates. The challenges posed by these often lethal biliary tract cancers are daunting, with conventional treatment options being limited and the only hope for long-term survival being that of complete surgical resection of the tumor. Unfortunately, the vast majority of patients with cholangiocarcinoma typically seek treatment with advanced disease, and often these patients are deemed poor candidates for curative surgery. Moreover, conventional chemotherapy and radiation therapy have not been shown to be effective in prolonging long-term survival, and although photodynamic therapy combined with stenting has been reported to be effective as a palliative treatment, it is not curative. Thus, there is a real need to develop novel chemopreventive and adjuvant therapeutic strategies for cholangiocarcinoma based on exploiting select molecular targets that would impact in a significant way on clinical outcome. This review focuses on potential preventive targets in cholangiocarcinogenesis, such as inducible nitric oxide synthase, cyclooxygenase-2, and altered bile acid signaling pathways. In addition, molecular alterations related to dysregulation of cholangiocarcinoma cell growth and survival, aberrant gene expression, invasion and metastasis, and tumor microenvironment are described in the context of various clinical and pathological presentations. Moreover, an emphasis is placed on the importance of critical signaling pathways and postulated interactions, including those of ErbB-2, hepatocyte growth factor/Met, interleukin-6/glycoprotein130, cyclooxygenase-2, vascular endothelial growth factor, transforming growth factor-β, MUC1 and MUC4, β-catenin, telomerase, and Fas pathways as potential molecular therapeutic targets in cholangiocarcinoma. cholangiocarcinoma. (Hepatology 2005;41:5-15.)