tbuckley/cabot-search huggingface dataset:
Regulation of intestinal and hepatic apoprotein synthesis after chronic fat and cholesterol feeding.
Authors: M F Go, G Schonfeld, B Pfleger, T G Cole, N L Sussman, D H Alpers
Journal: Journal of Clinical Investigation (1988)

Although diet influences levels of lipoproteins and their corresponding apoproteins, its effects on the molecular regulation of apoprotein synthesis are relatively unknown. Male Sprague-Dawley rats were fed an atherogenic diet containing cholesterol and propylthiouracil (PTU). Intestinal apo AI and AIV mRNA concentrations were decreased by the atherogenic diet, but apo AI and AIV synthesis was increased in vitro (organ explants) and in vivo (polysome runoff), consistent with regulation at the translational level. In contrast, hepatic apo E mRNA concentration and synthesis were increased after the atherogenic diet, consistent with pretranslational regulation. The response to cholesterol feeding for hepatic apo AI and E showed a third pattern of regulation, in which synthesis increased and mRNA content remained stable or fell, again suggesting translational control, but polysome runoff synthesis was unchanged. The apparent importance of translational regulation in the intestine is consistent with the necessity for the tissue to respond rapidly to changes in intraluminal content.
CHRONIC MUCOCUTANEOUS CAND1DIASIS, ENDOCRINE DEFICIENCY AND ALOPECIA AREATA
Authors: L. STANKLER, P. D. BEWSHER
Journal: British Journal of Dermatology (1972)

Summary.— A family with the endocrine candidiasis syntdrome is described, in which 3 members with idiopathic hypoparathyroidism also suffered from oral and cutaneous candidiasis. Alopecia areata developcd in l of the affected members, A review of 42 cases described in the literature revealed 13 patients with alopecia areata. The eyelashes or eyebrows were iiivolved in 12 patients. Addison's disease appears to be commoner in those patients with the syndrome who also have alopecia areata. The evidence from this retrospective analysis is not conclusive and merits further observation, but these findings are in keeping with a possible autoimmune aetiology for alopecia areata.
The effect of pressure or flow stress on right ventricular protein synthesis in the face of constant and restricted coronary perfusion.
Authors: S S Schreiber, M A Rothschild, C Evans, F Reff, M Oratz
Journal: Journal of Clinical Investigation (1975)

Cardiac stress produced by hypertension or excess volume loading results in different types of hypertrophy. Elevated left ventricular pressure rapidly results in increased myocardial protein synthesis in vivo and in vitro, but such rapid alterations are not consistently seen in volume loading. The difference in response is difficult to clarify since it is not possible to effect alterations in left ventricular pressure or perfusion without profoundly affecting coronary perfusion. The present study describes cardiac protein synthesis in the right ventricle of the young guinea pig heart in vitro by utilizing a perfusion model in which the right ventricle could be stressed by elevations of pressure or volume loading in the presence of constant and restricted coronary perfusion. With coronary flow maintained at 4 ml/min per heart equivalent to 25 ml/min/g dry wt, an increase in right ventricular pressure from normal levels of 3 mm Hg to 11 mm Hg resulted in a 60 percent increase of myocardial incorporation of (14C)lysine into protein. However, with further increases of right ventricular pressure to 22 mm Hg, protein synthesis dropped back to normal levels. The falloff in protein synthesis was not due to decreased contractility, alterations in intracellular lysine pool specific activity, or alterations in distribution of coronary flow. a 60 percent increase in coronary perfusion was again associated with a similar response of protein synthesis to progressive elevations of pressure despite a rise in the ATP levels and a fall in lactate production. Thus, a deficiency of O2 did not entirely explain the decline of protein synthesis with maximal pressures. At all levels of coronary perfusion, volume loading for 3 h did not result in increased protein incorporation of (14C)lysine. The studies support a relationship between ventricular pressure and protein synthesis unrelated to coronary flow per se. A pressure receptor triggering protein synthesis within the ventricular wall is postulated. Such a relationship is not apparent in short-term volume loading in vitro.
LYMPHOGRANULOMA VENEREUM OF THE HYPOPHARYNX AND LARYNX
Authors: Mervin C. Myerson
Journal: JAMA (1941)

Lymphogranuloma venereum is a systemic venereal disease caused by a filtrable virus and having an incubation period of from three to thirty days. It is characterized by a chronic granulomatous lesion which is generally confined to the anorectogenital region. Occasionally it is found in other parts of the body but rarely in the pharynx or larynx. Lymphogranuloma venereum must be differentiated from granuloma inguinale. The latter begins as an infection of the skin and subcutaneous tissues in which Donovan bodies can be demonstrated and is found almost exclusively in Negroes. On the other hand, lymphogranuloma venereum does not originate in the same structures and is not confined to Negroes. Buboes of venereal nature were known centuries ago, but it was not until 1913 that Durand, Nicolas and Favre<sup>1</sup>demonstrated that the disease causing them was transmitted through sexual intercourse. Hellerström<sup>2</sup>stated that the description given by Greek, Roman
Does stenting benefit patients with left anterior descending infarction? Results from the CADILLAC trial
Authors: Eulopio Garcia, David Cox, Cindy L. Grines, Raul Moreno, James Tcheng, Thomas Stuckey, Barry Rutherford, J. Mc Lean, John Carrol, Alexandra Lansky, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2002)
Distinguishing Central Nervous System Lymphoma from Toxoplasma Encephalitis
Authors: Christina Marra
Journal: Annals of Internal Medicine (1994)

Letters1 May 1994Distinguishing Central Nervous System Lymphoma from Toxoplasma EncephalitisChristina Marra, MDChristina Marra, MDUniversity of Washington School of Medicine; Seattle, WA 98104-2499Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-9-199405010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review of primary central nervous system lymphoma, Fine and Mayer [1] recommend an empiric treatment trial for toxoplasmosis in all patients with the acquired immunodeficiency syndrome (AIDS) and a computed tomographic (CT) scan of the cranium suggestive of toxoplasmosis or lymphoma. An alternative approach would be to reserve a toxoplasmosis treatment trial for patients with the highest likelihood of toxoplasmosis, such as those with detectable serum anti-Toxoplasma IgG, those with multiple mass lesions on cranial magnetic resonance imaging (MRI), or those receiving Pneumocystis prophylaxis with agents other than trimethoprim-sulfamethoxazole.The likelihood of Toxoplasma encephalitis is ...References1. Fine HA, Mayer RJ. Primary central nervous system lymphoma. Ann Intern Med. 1993; 119:1093-104. Google Scholar2. Luft BJ, Brooks RG, Conley FK, McCabe RE, Remington JS. Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome. JAMA. 1984; 252:913-7. Google Scholar3. Ciricillo SF, Rosenblum ML. Imaging of solitary lesions in AIDS (Letter). J Neurosurg. 1991; 74:1029. Google Scholar4. Cinque P, Brytting M, Vago L, Castagna A, Parravicini C, Zanchetta N, et al. Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system. Lancet. 1993; 342:398-401. Google Scholar5. Ruiz A, Ganz WI, Donnovan Post MJ. Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from Toxoplasma encephalitis in AIDS patients. 31st Annual Meeting of the American Society of Neuroradiology, 16 to 20 May 1993, Vancouver, British Columbia, Canada. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Washington School of Medicine; Seattle, WA 98104-2499 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLyme Disease Mimicking Central Nervous System Lymphoma 1 May 1994Volume 120, Issue 9Page: 812-813KeywordsCentral nervous systemComputed axial tomographyEncephalitisEpstein-Barr virusLesionsLymphomaPatientsThalliumToxoplasmaToxoplasmosis Issue Published: 1 May 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
American Medical Association provides guidance on medical tourism
Authors: J. Wapner
Journal: BMJ (2008)

The American Medical Association (AMA) has drawn up guidelines on medical tourism for patients, employers, insurers, and medical travel coordinators. The guidelines call for better public awareness about the need to coordinate care before and after operations. They also advocate that financial incentives to obtain care outside the US do not inappropriately limit the alternatives available to patients or restrict referral options and that patients are referred only to internationally …
Pinpointing clusters of apparently sporadic cases of Legionnaires' disease.
Authors: R. S. Bhopal, P. Diggle, B. Rowlingson
Journal: BMJ (1992)

OBJECTIVES--To test the hypothesis that many non-outbreak cases of legionnaires9 disease are not sporadic and to attempt to pinpoint cases clustering in space and time. DESIGN--Descriptive study of a case series, 1978-86. SETTING--15 health boards in Scotland. PATIENTS--203 probable cases of non-outbreak, non-travel, community acquired legionnaires9 disease in patients resident in Scotland. MAIN MEASURES--Date of onset of disease and postcode and health board of residence of cases. RESULTS--Space-time clustering was present and numerous groups of cases were identified, all but two being newly recognised. Nine cases occurred during three months within two postcodes in Edinburgh, and an outbreak was probably missed. In several places cases occurred in one area over a prolonged period--for example, nine cases in postcode districts G11.5 and G12.8 in Glasgow during five years (estimated mean annual incidence of community acquired, non-outbreak, non-travel legionnaires9 disease of 146 per million residents v 4.8 per million for Scotland). Statistical analysis showed that the space time clustering of cases in the Glasgow and Edinburgh areas was unusual (p = 0.036, p = 0.068 respectively). CONCLUSION--Future surveillance requires greater awareness that clusters can be overlooked; case searching whenever a case is identified; collection of complete information particularly of date of onset of the disease and address or postcode; ongoing analysis for space-time clustering; and an accurate yet workable definition of sporadic cases. Other researchers should re-examine their data on apparently sporadic infection.
Incomes: vive la difference
Authors: J. Dixon
Journal: BMJ (1976)

Incomes: vive la difference SIR,-Mr Rudolf Klein (10 July, p 126) is right.There can never be a fixed rule that previous differentials between the medical professions and other workers should always be rightly maintained-of course times change.However, to round it off he should also have said that there is no rule that the medical profession's training and expertise, sense of responsibility, and willingness to do unpaid overtime should continue without a change.These two aspects, differentials and pro- fessional standards,
AIDS and the Nervous System
Authors: Maurice Victor
Journal: JAMA (1989)

This monograph represents the most current and comprehensive account to date of the neurological disorders associated with the acquired immunodeficiency syndrome (AIDS). The core of this account is the personal clinical and pathological experience of the editors, based on their observations of a remarkable number (1286) of AIDS patients. In addition, the editors have enlisted contributions from 35 eminent investigators, each of whom has written authoritatively on some aspect or aspects of the neurology of AIDS. The volume comprises five main subjects, each of which is considered in intimate detail: The first subject is the neuroepidemiology of AIDS. The data presented by the authors are impressive and frightening. It is estimated (conservatively) that in 1991, there will be 74 000 new cases of AIDS and 54 000 deaths from the disease—making it the fourth commonest cause of death in the United States, after heart disease, cancer, and stroke. Clinically, neurological
Causes, investigation and treatment of leg ulceration
Authors: J.R. Mekkes, M.A.M. Loots, A.C. Van Der Wal, J.D. Bos
Journal: British Journal of Dermatology (2003)

Summary Chronic ulceration of the lower leg is a frequent condition, with a prevalence of 3–5% in the population over 65 years of age. The incidence of ulceration is rising as a result of the ageing population and increased risk factors for atherosclerotic occlusion such as smoking, obesity and diabetes. Ulcers can be defined as wounds with a 'full thickness depth' and a 'slow healing tendency'. In general, the slow healing tendency is not simply explained by depth and size, but caused by an underlying pathogenetic factor that needs to be removed to induce healing. The main causes are venous valve insufficiency, lower extremity arterial disease and diabetes. Less frequent conditions are infection, vasculitis, skin malignancies and ulcerating skin diseases such as pyoderma gangrenosum. But even rarer conditions exist, such as the recently discovered combination of vasculitis and hypercoagulability. For a proper treatment of patients with leg ulcers, it is important to be aware of the large differential diagnosis of leg ulceration.
NPM-ALK Oncogenic Tyrosine Kinase Controls T-Cell Identity by Transcriptional Regulation and Epigenetic Silencing in Lymphoma Cells
Authors: Chiara Ambrogio, Cinzia Martinengo, Claudia Voena, Fabrizio Tondat, Ludovica Riera, Paola Francia di Celle, Giorgio Inghirami, Roberto Chiarle
Journal: Cancer Research (2009)

Transformed cells in lymphomas usually maintain the phenotype of the postulated normal lymphocyte from which they arise. By contrast, anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma with aberrant phenotype because of the defective expression of the T-cell receptor and other T-cell-specific molecules for still undetermined mechanisms. The majority of ALCL carries the translocation t(2;5) that encodes for the oncogenic tyrosine kinase NPM-ALK, fundamental for survival, proliferation, and migration of transformed T cells. Here, we show that loss of T-cell-specific molecules in ALCL cases is broader than reported previously and involves most T-cell receptor-related signaling molecules, including CD3epsilon, ZAP70, LAT, and SLP76. We further show that NPM-ALK, but not the kinase-dead NPM-ALK(K210R), downregulated the expression of these molecules by a STAT3-mediated gene transcription regulation and/or epigenetic silencing because this downregulation was reverted by treating ALCL cells with 5-aza-2-deoxycytidine or by knocking down STAT3 through short hairpin RNA. Finally, NPM-ALK increased the methylation of ZAP70 intron 1-exon 2 boundary region, and both NPM-ALK and STAT3 regulated the expression levels of DNA methyltransferase 1 in transformed T cells. Thus, our data reveal that oncogene-deregulated tyrosine kinase activity controls the expression of molecules that determine T-cell identity and signaling.
Developing clues to environmental cancer: a stepwise approach with the use of cancer mortality data.
Authors: W J Blot, J F Fraumeni, T J Mason, R N Hoover
Journal: Environmental Health Perspectives (1979)

Clues to environmental determinants can often be derived from the patterns of mortality from cancer. This review focuses on the stepwise approach of using cancer mortality maps, supplemented by correlation studies linking mortality rates with demographic and industrial data at the county level, to generate hypotheses to cancer etiology which can then be pursued by analytical epidemiological studies. Advantages and limitations of this approach and its application in the study of lung cancer in the United States are described.
A COMBINED GASTROSCOPE AND GYROMELE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES.
Authors: FENTON B. TURCK
Journal: JAMA (1903)

Gastroscopy is used to determine the condition of the mucous membrane of the stomach by inspection. For this purpose a stiff tube is used with an electric light at the end and a reflector to carry the image to the eye through a system of lenses within the tube. The method of such examination demands the use of a long, straight, rigid tube reaching far into the stomach. The possibility of introducing a long, stiff, straight instrument has been shown to be possible in the exhibitions made by sword swallowers. Leube<sup>1</sup>recommended a stiff sound introduced into the stomach to be palpated through the abdominal wall for the purpose of determining dilatation of the stomach. When it was found practical to introduce a stiff, straight instrument into the stomach the idea of inspection of the gastric cavity through a hollow, straight tube naturally presented itself. Mikulicz<sup>2</sup>was the first to
Type VII collagen gene expression by cultured human cells and in fetal skin. Abundant mRNA and protein levels in epidermal keratinocytes.
Authors: J Ryynänen, S Sollberg, M G Parente, L C Chung, A M Christiano, J Uitto
Journal: Journal of Clinical Investigation (1992)

Type VII collagen, a genetically distinct member of the collagen family, is present in the cutaneous basement membrane zone as an integral component of the anchoring fibrils. We have recently isolated several cDNAs that correspond to human type VII collagen sequences. One of these cDNAs (clone K-131) was utilized to examine type VII collagen gene expression in cultures of human cells by Northern analyses, in situ hybridizations and indirect immunofluorescence. Northern hybridizations revealed the presence of an approximately 9-kb mRNA transcript, and indicated a high level of expression in epidermal keratinocytes as well as in an oral epidermoid carcinoma cell line (KB), while the expression was considerably lower in skin fibroblasts and in several virally or spontaneously transformed epithelial cell lines. In situ hybridizations of cultured keratinocytes supported the notion of a high level of gene expression. Indirect immunofluorescence of skin from a 19-wk fetus revealed type VII collagen gene expression at the dermal-epidermal basement membrane zone. These results indicate that several different cell types including epidermal keratinocytes and dermal fibroblasts express the type VII collagen gene, but epidermal keratinocytes may be the primary cell source of type VII collagen in developing human skin.
INFLAMMATION AND CORONARY MICROVASCULAR DYSFUNCTION ASSESSED BY CARDIOPULMONARY EXERCISE TESTING IN PATIENTS WITH CARDIAC SYNDROME X
Authors: Alberto Dominguez-Rodriguez, Pedro Abreu-Gonzalez, Pablo Avanzas, Maria del Carmen Garcia-Baute, Maria Angeles Gomez, Antonio Lara-Padron, Juan Carlos Kaski
Journal: Journal of the American College of Cardiology (2011)
Mortality and morbidity after hip fractures
Authors: T R O Beringer
Journal: BMJ (1994)

1985 House of Lords ruling in Gillick v DHSS, which still holds good today, may serve to remind doctors of the duty they owe to parents and to their profession.Lord Justice Fraser: "Nobody doubts that in the overwhelming majority of cases the best judges of a child's welfare are his or her parents.Nor do I doubt that any important medical treatment of a child under 16 would normally only be carried out with the parent's approval.That is why it would and should be 'most unusual' for a doctor to advise a child without the knowledge and consent of the parents on contraceptive matters."Lord Justice Scarman: "I accept that great responsibilities will lie on the medical profession.It is however a learned and highly trained profes- sion, regulated by statute and governed by a strict ethical code which is vigorously enforced.Abuse of the power to prescribe contraceptive treatment for girls under the age of 16 would render a doctor liable to severe professional penalty."
Toward Automating Clinical Assessments: A Survey of the Timed Up and Go
Authors: Gina Sprint, Diane J. Cook, Douglas L. Weeks
Journal: IEEE Reviews in Biomedical Engineering (2015)

Older adults often suffer from functional impairments that affect their ability to perform everyday tasks. To detect the onset and changes in abilities, healthcare professionals administer standardized assessments. Recently, technology has been utilized to complement these clinical assessments to gain a more objective and detailed view of functionality. In the clinic and at home, technology is able to provide more information about patient performance and reduce subjectivity in outcome measures. The timed up and go (TUG) test is one such assessment recently instrumented with technology in several studies, yielding promising results toward the future of automating clinical assessments. Potential benefits of technological TUG implementations include additional performance parameters, generated reports, and the ability to be self-administered in the home. In this paper, we provide an overview of the TUG test and technologies utilized for TUG instrumentation. We then critically review the technological advancements and follow up with an evaluation of the benefits and limitations of each approach. Finally, we analyze the gaps in the implementations and discuss challenges for future research toward automated self-administered assessment in the home.
ATYPICAL SCALP RINGWORM CAUSED BY MICROSPORUM CANIS
Authors: G. H. Findlay
Journal: British Journal of Dermatology (1974)

Journal Article ATYPICAL SCALP RINGWORM CAUSED BY MICROSPORUM CANIS Get access G. H. Findlay G. H. Findlay Section of Dermatology, University of Pretoria, Pretoria, South Africa Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 90, Issue 5, 1 May 1974, Pages 584–585, https://doi.org/10.1111/j.1365-2133.1974.tb06461.x Published: 01 May 1974
Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome
Authors: Colleen E. Clancy, Michihiro Tateyama, Robert S. Kass
Journal: Journal of Clinical Investigation (2002)

Congenital long QT syndrome is a rare disease in which the electrocardiogram QT interval is prolonged due to dysfunctional ventricular repolarization. Variant 3 (LQT-3) is associated with mutations in SCN5A, the gene coding for the heart Na+ channel α subunit. Arrhythmias in LQT-3 mutation carriers are more likely to occur at rest, when heart rate is slow. Several LQT-3 Na+ channel mutations exert their deleterious effects by promoting a mode of Na+ channel gating wherein a fraction of channels fails to inactivate. This gating mode, termed "bursting, " results in sustained macroscopic inward Na+ channel current (Isus), which can delay repolarization and prolong the QT interval. However, the mechanism of heart-rate dependence of Isus has been unresolved at the single-channel level. We investigate an LQT-3 mutant (Y1795C) using experimental and theoretical frameworks to elucidate the molecular mechanism of Isus rate dependence. Our results indicate that mutation-induced changes in the length of time mutant channels spend bursting, rather than how readily they burst, determines Isus inverse heart-rate dependence.