tbuckley/cabot-search huggingface dataset:
Irritable Bowel Syndrome
Authors: Stanley M. Charnoff
Journal: Annals of Internal Medicine (1995)

Letters15 September 1995Irritable Bowel SyndromeStanley M. Charnoff, MDStanley M. Charnoff, MDSunset Park Family Health Center; Brooklyn, NY 11220Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-6-199509150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The long-term study of the irritable bowel syndrome by Owens and colleagues [1] appears to confirm the generally benign course found by others. The authors recorded hospital admissions and surgeries but make no comment in this area. They note that 100 of 112 patients were subjected to one of four types of surgery (appendectomy, hysterectomy, cholecystectomy, or laparotomy).This finding raises several pertinent questions about the relation between the diagnosis of the irritable bowel syndrome and the need for abdominal or pelvic surgery. Was the primary diagnosis correct? Were the surgeries done because of misdiagnosis of symptoms ...References1. Owens DM, Nelson DK, Talley NJ. The irritable bowel syndrome: long-term prognosis and the physician–patient interaction. Ann Intern Med. 1995; 122:107-12. Google Scholar Author, Article, and Disclosure InformationAffiliations: Sunset Park Family Health Center; Brooklyn, NY 11220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1995Volume 123, Issue 6Page: 471KeywordsAbdominal surgeryAppendectomyCholecystectomyHysterectomyIrritable bowel syndromeLaparotomySurgery Issue Published: 15 September 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Persistence of cytomegalovirus in peripheral blood from blood donors.
Authors: D. J. Morris, C. P. Kimptoh, G. Corbitt
Journal: BMJ (1989)

depend on valproate for optimal control of their seizures throughout the childbearing years.5It is clearly of enormous importance that women with primary generalised epilepsies are differentiated from those with partial epilepsy, who will be best managed with carbamazepine.They are a group requiring specific counselling of the small risks of valproate to any pregnancy and needing screening of any pregnancy for neural tube defects within the first trimester.Patients themselves can probably best decide whether they wish to take the most effective drug and accept a small risk of neural tube defect or to take a less optimal drug that might be somewhat safer in pregnancy.
Relationships among salivary cortisol, RPE and training intensity in duet synchronised swimmers during pool session training
Authors: A Y W Tan, Y Long
Journal: British Journal of Sports Medicine (2010)

The aim of this study was to evaluate the correlations of stress hormone responses, rating of perceived exertion (RPE) and training intensity of duet synchronised swimmers during pool training sessions over a 1-week training cycle. Five synchronised swimmers (21±3 years, body mass 52±4 kg, height 163±3 cm) undertook their weekly pool training session. A 2-min saliva sample was collected before and after training for the analysis of salivary cortisol. Total training time, heart rate and rating of RPE were recorded at the end of the session. Exercise intensity was defined as “light” (≤54%), “moderate” (55%-69%), “high” (70%-89%) and “very high” (≥90%) in relation to maximum heart rate. Swimmers spent 39%, 34%, 25% and 2% of their total training time for light, moderate, high and very high intensity, respectively. Post-training salivary cortisol was correlated with RPE (r=0.64, p&lt;0.005). Post-training salivary cortisol and RPE was correlated with all four intensities, (p&lt;0.000; p&lt;0.001; p&lt;0.000; p&lt;0.005); the increase in post-training cortisol and RPE was highly correlated with high intensity training (r=0.68, p&lt;0.000). The results show that post-training salivary cortisol and RPE are closely correlated and are highly correlated to high intensity in synchronised swimmers' pool training. Both salivary cortisol and RPE can be used to indicate the pool session training intensity accurately.
INDUCTION OF IMMUNOLOGIC TOLERANCE IN OLDER NEW ZEALAND MICE REPOPULATED WITH YOUNG SPLEEN, BONE MARROW, OR THYMUS
Authors: Parker J. Staples, Alfred D. Steinberg, Norman Talal
Journal: The Journal of Experimental Medicine (1970)

Newborn, 7-9 day, and 16-18 day old NZB and B/W mice were, unlike older New Zealand mice, rendered tolerant to single doses of 8-10 mg of soluble BGG. After challenge, this tolerance was of short duration and escape occurred rapidly. Age-matched and similarly treated C3H, Balb/c and C57Bl mice did not escape from tolerance. Partial tolerance could be maintained by repeated injections of BGG. Biofiltration ruled out hyperphagocytosis as an explanation for this resistance to tolerance. Tolerance could be induced in older B/W mice if they were thymectomized, irradiated, and repopulated with young (12-15 day), but not old (2-3 month), spleen or bone marrow cells. Old bone marrow cells gave a non-tolerant response even when combined with young thymic grafts. Young bone marrow gave a tolerant response which was followed by the expected rapid escape only if a young thymus graft was also present. Escape was retarded if old thymus, or old irradiated thymus, was combined with young bone marrow. These results are best explained by abnormalities of both lymphoid precursors and thymic regulation.
113 KERATIN19: A KEY ROLE PLAYER IN THE INVASION OF HUMAN HEPATOCELLULAR CARCINOMAS WITH PROGENITOR CELL FEATURES
Authors: O. Govaere, M. Komuta, B. Spee, A. Durnez, S. Vander Borght, C. Verslype, R. Aerts, B. Topal, J. Pirenne, F. Nevens, V.J. Desmet, L.R. Roberts, S.S. Thorgeirsson, T. Roskams
Journal: Journal of Hepatology (2012)
Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
Authors: Werner Hacke, Geoffrey Donnan, Cesare Fieschi, Markku Kaste, Rüdiger von Kummer, Joseph P Broderick, Thomas Brott, Michael Frankel, James C Grotta, E Clarke Haley, Thomas Kwiatkowski, Steven R Levine, Chris Lewandowski, Mei Lu, Patrick Lyden, John R Marler, Suresh Patel, Barbara C Tilley, Gregory Albers, Erich Bluhmki, Manfred Wilhelm, Scott Hamilton
Journal: The Lancet (2004)
The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation
Authors: Jacob Nattermann, Jörg Timm, Hans Dieter Nischalke, Anne Olbrich, Monika Michalk, Hans L. Tillmann, Thomas Berg, Heiner Wedemeyer, Hannelore Tenckhoff, Manfred Wiese, Ulrike Kullig, Uwe Göbel, Emanuela Capka, Ingolf Schiefke, Wolfgang Güthof, Kurt Grüngreiff, Ingrid König, Michael Roggendorf, Tilman Sauerbruch, Ulrich Spengler
Journal: Journal of Hepatology (2011)
Silicone for Facial Furrows
Authors: JOHN M. GOIN
Journal: JAMA (1974)

<h3>To the Editor.—</h3> In QUESTIONS AND ANSWERS (229:204, 1974), two consultants discussed dermabrasion for cosmetic purposes in a patient with scleroderma. Both advised against it on the grounds that reepithelialization following dermabrasion depends on the presence of dermal appendages (sebaceous glands, sweat glands, and hair follicles) that may be absent in the late stage of scleroderma. I agree entirely. Nowhere in medicine is it more important to guard against harming a patient than when one is contemplating a procedure intended solely to improve appearance. I was surprised and concerned, therefore, to read Dr. Stephen B. Kurtin's suggestion that liquid silicone injections be tried to correct the "furrowing" of the 58-year-old patient's face. Silicone injections are, at present, an experimental procedure. Untold damage and suffering has been inflicted by unscrupulous or immature practitioners who have injected virtually every surface area of patients seeking aesthetic improvement. I have seen eyelids, breasts, cheeks,
Migration of Polytetrafluoroethylene—Polytef
Authors: Victor A. Politano
Journal: JAMA (1985)

To the Editor.—  I read the article by Malizia et al1with more than a passing interest, since I initiated the concept and described the technique of polytef injection for urinary incontinence.2  It is common knowledge that any injected particle, whether polytef or charcoal, will migrate to regional nodes and distant places. We observed this in our initial studies in dogs and again in later studies in guinea pigs in which migration of polytef paste, floc, and microstrands were compared. All materials migrated in varying amounts. The issue, then, is not the migration of particles, for they indeed do migrate. The issue is whether the particles that remain at the injection site, or that migrate, produce any harm. Prosthetic devices, such as penile implants, artificial sphincters, valves, and vessel replacements are being used in increasing numbers. There is a constant reaction between the prosthetic device and adjacent tissue
The long-term follow-up results of alcohol septal ablation for symptomatic hypertrophic obstructive cardiomyopathy: the Baylor experience (1996–2001)
Authors: Valerian L. Fernandes, Sherif F. Nagueh, Nasser M. Lakkis, Jennifer Franklin, Robert Roberts, William H. Spencer
Journal: Journal of the American College of Cardiology (2002)
Influenza Immunization Procedures
Authors: Samuel L. Katz
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Dr. Tuft is correct in nearly all that he has stated in his reply to my recent answer published in your QUESTIONS AND ANSWERS column. However, I do not think he really takes issue with me, because we seem to be in agreement except for the matter of emphasis. In his discussion of the efficacy of intradermal vaccination he underlines what I had already stated. The only major disagreement would be his comments upon the incidence and severity of reactions after subcutaneous administration of influenza vaccines. The paper which he cites is from a 1962 report and the data would not be tenable with present vaccines. The improvements in technology of vaccine development and production have resulted in influenza antigens which are far less reactigenic, and the presently available vaccines prepared by zonal ultracentrifugation are practically free of reactions in many populations. Nevertheless, I must continue to
A Rude Awakening — The Perioperative Sleep Apnea Epidemic
Authors: Stavros G. Memtsoudis, Melanie C. Besculides, Madhu Mazumdar
Journal: New England Journal of Medicine (2013)

Obstructive sleep apnea may increase the risk of perioperative complications and is more prevalent among candidates for surgery than in the general population. With more than 40 million surgical procedures performed annually, the costs are high.
Task force pinpoints sources of excess deaths in blacks
Authors: William A. Check
Journal: JAMA (1986)

The story of the Task Force on Black and Minority Health, and its report, begins at least three years ago. In 1983, as in every recent year, the Cabinet-level secretary who heads the Department of Health and Human Services in Washington, DC, was presented with a report on the health status of the nation. And, as in most recent years, the report noted that the health status of Americans generally had improved, but that the gap in mortality between black and white persons (with more black persons dying at earlier ages) had remained relatively constant. But that year something different happened. Margaret Heckler, who was head of the Department of Health and Human Services in 1983, commissioned the Task Force on Black and Minority Health to try to find reasons for this gap. The department's 18 senior officials who were named to the task force also were to try to
Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-β-Catenin Pathway
Authors: Bang H. Hoang, Tadahiko Kubo, John H. Healey, Rui Yang, Saminathan S. Nathan, E. Anders Kolb, BethAnne Mazza, Paul A. Meyers, Richard Gorlick
Journal: Cancer Research (2004)

Osteosarcoma (OS) is a primary malignancy of bone with a tendency to metastasize early. Despite intensive chemotherapy and surgical resection, approximately 30% of patients still develop distant metastasis. Our previous work using clinical OS samples suggested that expression of the Wnt receptor LRP5 might be associated with tumor metastasis. In the present study, we used a Dickkopf (Dkk) family member and a dominant-negative LRP5 receptor construct to modulate Wnt signaling in OS cells. Saos-2 cells, which ectopically express Dkk-3, do not undergo apoptosis and exhibit enhanced resistance to serum starvation and chemotherapy-induced cytotoxicity. Transfection of Dkk-3 and dominant-negative LRP5 into Saos-2 cells significantly reduces invasion capacity and cell motility. This blockade is associated with changes in cell morphology consistent with a less invasive phenotype. In addition, Dkk-3 and dominant-negative LRP5 also induce changes in beta-catenin localization consistent with an increase in cell-cell adhesion. Taken together, these results support a possible role for Wnt signaling in the pathobiology and progression of human OS.
Nobel Peace Prize Lecture
Authors: Bernard Lown
Journal: New England Journal of Medicine (1986)

When Alfred Nobel drafted his final will in late 1895, thus providing this enduring and monumental legacy, the world was charged with anticipation and optimism for the 20th century. Mind and hand, the distinctive attributes of our species, were at last finding their intertwined fulfillment in science and technology. Science at the fin de siecle promised mastery of a hostile environment and an end to chaotic societal relations punctuated by war and brutality. Advancing technology augured unlimited potential for human power, inspiring a dream for an end to drudgery and for an age of abundance.The hope of a benevolent . . .
Interaction between anticoagulants and contraceptives: an unsuspected finding.
Authors: E de Teresa, A Vera, J Ortigosa, L A Pulpon, A P Arus, M de Artaza
Journal: BMJ (1979)

To assess the effects of oral contraceptives on anticoagulant treatment the prothrombin times of 12 patients were measured while they were taking both drugs simultaneously and while they were taking only anticoagulants. The mean prothrombin time ratio was significantly higher when patients were taking both drugs than when they were taking only anticoagulants and their doses of anticoagulant were significantly lower. During both periods most of the prothrombin values remained in the therapeutic range. These findings suggest that, contrary to the common belief that oral contraceptives diminish the effects of anticoagulants, contraceptives in fact potentiate the action of the anticoagulants.Of 197 patients with heart disease on oral anticoagulant treatment (nicoumalone) 12 were simultaneously taking an estroprogestogenic oral contraceptive. The patients were aged 27-44 years old and anticoagulation control was maintained by measuring prothrombin activity. For 230 months the women took anticoagulant only. The mean prothrombin time ratio was significantly higher when the women were taking both the anticoagulant and the pill than taking only the anticoagulant, but the prothrombin values were in the therapeutic range during both periods. The oral contraceptive seems to potentiate anticoagulation activity not diminish their effect. It is suggested that the estrogen in the pill may produce enzymatic inhibition in microsomes of hepatic cells which potentiate anticoagulant activity through retarded metabolic degradation.
Heterotopic tracheal transplants: techniques and applications.
Authors: A J Klein-Szanto, B C Pal, M Terzaghi, A C Marchok
Journal: Environmental Health Perspectives (1984)

Heterotopic tracheal transplants, placed subcutaneously in syngeneic rats have been extensively used in our laboratory. The objective of these experiments was to study the toxic and/or carcinogenic effect of several compounds on the respiratory tract mucosa. This was attained by exposing the transplants to an intraluminal pettet containing the toxicant or carcinogen mixed with an adequate matrix (gelatin, beeswax, stearyl alcohol, silastic, etc.). By varying the concentration of the test chemicals, it is possible to study dose-response relationships, and by changing the pellet matrix, the effects of release rate (dose rate) can be analyzed. Several end points can be studied, such as histological changes in the mucociliary epithelium, changes in mucus secretion, tumor induction and changes in the in vitro behavior of the epithelial cells after in vivo exposure. In addition, by de-epithelializing the tracheal transplants and reseeding them with another cell population, e.g., from previously treated cell cultures or from human specimens and transplanting them subcutaneously in nude mice, completely new vistas on the effect of chemicals can be opened.
Parent support groups
Authors: L. Marks
Journal: BMJ (1992)

time to take effect.Our patients described their recovery in terms of a "cracked mirror" 10-15 minutes after the injection.Angiography was performed 60 minutes after injection and showed complete reopening.With regard to the adverse side effects mentioned by Pandit and Tiamiyu, cardiac arrhythmias were reported after longer administra- tion of higher doses of steroids (4x 30 mg/kg daily),' not after a single 1000 mg bolus, which is not a massive dose.Steroids are an effective measure against anaphylactic shock.4Are anaphy- lactoid reactions to steroids really common?We tried to show the effect of steroids on vessel walls and offered angiographic evidence that occluded vessels became completely perfused 60 minutes later.A steroid bolus seems to us to be a suitable emergency treatment that does not inter- fere with other drugs for this condition.Any other treatment may be given simultaneously or after- wards.
Legal abortion in England and Wales 1968-78.
Authors: T L Lewis
Journal: BMJ (1980)

In the 11 years since the Abortion Act 1967 came into effect 1 325 146 legal abortions have been performed in England and Wales.This report gives various statistics on abortions performed in England and Wales since the 1967 Act. Figures on abortionsFor each of the first six years the number of abortions increased up to 167 149 in 1973, since when the annual total has fallen slightly.Abortions performed on women resident in England and Wales climbed to a peak of 110 568 in 1973, since when the yearly figure has remained at about the same level, except for slight falls in 1976 and 1977.Abortions performed on women from abroad rose to 56 581 in 1973, since when they have fallen to almost half (table I).TABLE i-Ntumbers of legal abortions performed in England and Wales 1968-78 in residents and non-residents No performed on No performed on
Relationship of Fibrillatory Waves and P Waves in the Electrocardiogram
Authors: ROBERT H. PETER, JAMES J. MORRIS, HENRY D. MCINTOSH
Journal: Circulation (1966)

The amplitude of the fibrillatory waves and the P terminal force were compared in 100 consecutive patients. These electrocardiographic measures of atrial activity were made first in atrial fibrillation and then after electrical conversion to sinus rhythm. When the same patient was studied, the occurrence of a coarse fibrillatory wave and an abnormal P terminal force, or a fine fibrillatory wave and a normal P terminal force, was found to be a highly significant relationship. This relationship suggests that the factors responsible for the characteristic of the terminal portion of the P wave recorded in sinus rhythm probably determine the magnitude of the fibrillatory wave that occurs when atrial fibrillation is present. The finding of a coarse fibrillatory wave or an abnormal P terminal force should suggest the electrocardiographic diagnosis of left atrial hypertrophy or "strain."
Exclusion of the Elderly and Women From Coronary Trials
Authors: Nanette K. Wenger
Journal: JAMA (1992)

Increasing numbers of elderly individuals have changed not only the profile of the US population, but also the demography of cardiovascular disease. Currently, 13% of the population is older than age 65 years; this percentage is expected to increase to 21%, or 35 million people, by the year 2030. The "oldest old," or those 85 years old or older, number 2.7 million individuals; they constitute the most rapidly growing subgroup among the elderly, with a projected sixfold increase by the year 2030.<sup>1</sup>Although studies to guide the therapeutic management of this rapidly growing portion of our population should warrant high priority, the age-based exclusions of contemporary clinical trials limit this process.<sup>2</sup>Coronary heart disease increasingly is a disease of and cause of death among the aging population. The majority of US patients with clinical manifestations of coronary heart disease are older than 65 years; more than half of
What do internal medicine residents need to enhance their diabetes care?
Authors: A M Bernard, L Anderson, C B Cook, L S Phillips
Journal: Diabetes Care (1999)

OBJECTIVE: To identify areas that should be targeted for improvement in care, we examined internal medicine resident practice patterns and beliefs regarding diabetes in a large urban hospital outpatient clinic. RESEARCH DESIGN AND METHODS: Internal medicine residents were surveyed to assess the frequency at which they performed key diabetes quality of care indicators. Responses were compared with recorded performance derived from chart and laboratory database reviews. Resident attitudes about diabetes were determined using the Diabetes Attitude Survey for Practitioners. Finally, an eight-item scale was used to assess barriers to diabetes care. RESULTS: Both self-described and recorded performance of recommended diabetes services short of national recommendations. For yearly eye examinations and lipid screening, recorded performance levels were similar to trainees' reports. However, documented inquiries about patient self-monitoring of blood glucose, performance of foot examinations, and urine protein screening were lower than trainees' reports. Some 49% of the residents selected a target HbA1c of 6.6-7.5% as an attainable goal, yet half of the patients using oral agents or insulin had HbA1c values &amp;gt; 8.0%. No differences in self-described or recorded performance were found by year of training. Most residents did not perceive themselves to need additional training related to diabetes care, and residents were generally neutral about patient autonomy. Patient nonadherence and time constraints within the clinic were most often cited as barriers to care. CONCLUSIONS: The study identifies several areas that require improvement in resident care of diabetes in the ambulatory setting. Because experience during training contributes to future practice patterns, developing a program that teaches trainees how to implement diabetes practice guidelines and methods to achieve optimal glycemic control may be key to future improvements in the quality of diabetes care.
CEACAM1: A Novel Urinary Marker for Bladder Cancer Detection
Authors: Derya Tilki, Bernhard B. Singer, Shahrokh F. Shariat, Andreas Behrend, Malkanthi Fernando, Ster Irmak, Alexander Buchner, Andrea T. Hooper, Christian G. Stief, Oliver Reich, Süleyman Ergün
Journal: European Urology (2009)