Insulin-Induced Lipodystrophy in Diabetic Patients Resolved by Treatment with Human Insulin
Authors: LUBOMIR J. VALENTA
Journal: Annals of Internal Medicine (1985)

Brief Reports1 June 1985Insulin-Induced Lipodystrophy in Diabetic Patients Resolved by Treatment with Human InsulinLUBOMIR J. VALENTA, M.D., Ph.D., ALAN N. ELIAS, M.D.LUBOMIR J. VALENTA, M.D., Ph.D., ALAN N. ELIAS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-6-790 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLipoatrophy occurs with high frequency in diabetic patients treated with conventional bovine-porcine insulin preparations (1-3), but is rare in patients receiving the highly purified porcine insulins (1), although single cases have been reported (4, 5). In view of the smaller incidence of this complication with the purified insulins, insulin-induced lipoatrophy is believed to have an immune pathogenesis (6).We report the cases of five patients with diabetes mellitus who developed lipoatrophy at the sites of insulin injection. Three of the patients were later treated with highly purified porcine insulin (Nordisk, Bethesda, Maryland), which failed to produce any regression of the...References1. WRIGHTWALSHFITZGERALDMALINS ACMJ. Very pure porcine insulin in clinical practice. Br Med J. 1979;1:25-7. CrossrefMedlineGoogle Scholar2. RENOLDWINEGRADMARKINS AAD. Diabete sucre' et tissue adipeux. Helv Med Acta. 1957;24:322-7. MedlineGoogle Scholar3. PALEY R. Lipodystrophy following insulin injections. Metabolism. 1953;2:201-10. MedlineGoogle Scholar4. JONESSTATHAMOWENSJONESHAYES GBDMT. Lipoatrophy and monocomponent porcine insulin. Br Med J. 1981;282:190. CrossrefMedlineGoogle Scholar5. HANAIKATOKAWASAKI NNM. Lipoatrophy due to monocomponent insulin. J Jap Diabetic Soc. 1976;19:427-8. Google Scholar6. REEVESALLENTATTERSALL WBR. Insulin-induced lipoatrophy: evidence for an immune pathogenesis. Br Med J. 1980;2:1500-3. CrossrefGoogle Scholar7. ARTHUS M. Injections repetees de serum de cheral chez le lapin. Comptes Rendus Soc Biologie. 1903;55:817-20. Google Scholar8. ARTHUSBRETON MM. Lesions cutanees produites par les injection de serum de cheral chez le lapin anaphylactise' par et pou et serum. Comptes Rendus Soc Biologie. 1903;55:1478-80. Google Scholar9. KAHNROSENTHAL CA. Immunologic reaction to insulin: insulin allergy, insulin resistance, and the autoimmune insulin syndrome. Diabetes Care. 1979;2:283-95. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Diabetes and Endocrine Clinic of North County Oceanside, California University of California Orange, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByWas die Haut eines Diabetikers verrätWas die Haut des Diabetikers verrätWas die Haut des Diabetikers verrätInsulinSulfonylureasAbdominal Incision and Injection SitesInsulin Injection Lipoatrophy RecidivusDisorders of Fat TissueTherapy of Type 1 Diabetes MellitusHautveränderungen bei Diabetes mellitusINSULINS AND OTHER HYPOGLYCEMIC DRUGSSkin problems due to insulin useLispro insulin-induced lipoatrophy: a new caseInsulinSulfonylureasInsulin therapy is associated with skin-related complications that influence glycaemic controlComplications of Insulin TherapySkin-Related Complications of Insulin TherapyOverview of Biotechnology in Health CareAnnular atrophic connective tissue panniculitis of the anklesA practical guide to using insulinInsulin, glucagon and oral hypoglycemic drugs 1 June 1985Volume 102, Issue 6Page: 790-791KeywordsDiabetes mellitusEndocrinologyInsulinLipodystrophyPathogenesisPatients Issue Published: 1 June 1985 PDF DownloadLoading ...