STREPTOMYCIN IN THE TREATMENT OF TUBERCULOSIS IN HUMANS
Authors: CARL MUSCHENHEIM
Journal: Annals of Internal Medicine (1947)

Article1 December 1947STREPTOMYCIN IN THE TREATMENT OF TUBERCULOSIS IN HUMANSII. PULMONARY TUBERCULOSIS*CARL MUSCHENHEIM, F.A.C.P., WALSH MCDERMOTT, SUSAN J. HADLEY, HARRIET HULL-SMITH, ALICE TRACYCARL MUSCHENHEIM, F.A.C.P.Search for more papers by this author, WALSH MCDERMOTTSearch for more papers by this author, SUSAN J. HADLEYSearch for more papers by this author, HARRIET HULL-SMITHSearch for more papers by this author, ALICE TRACYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-6-989 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIn a preceding paper,1 observations on the streptomycin treatment of meningeal and generalized hematogenous tuberculosis were presented. On the basis of these studies and in confirmation of the previous reports of Hinshaw and Feldman,2, 3 it was concluded that streptomycin is capable of exerting a powerful effect upon the course of tuberculous infections in humans. It was further concluded1 that in miliary tuberculosis, at least, the development of streptomycin-resistance as detected in vitro, reflects the presence of a drug-resistant infection in vivo.The present report is concerned with the results observed in 43 patients with pulmonary tuberculosis who received...Bibliography1. MCDERMOTTMUSCHENHEIMHADLEYBUNNGORMAN WCSJPARV: Streptomycin in the treatment of tuberculosis in humans. I. Meningitis and generalized hematogenous tuberculosis, Ann. Int. Med., 1947, xxvii, 769-822. LinkGoogle Scholar2. HINSHAWFELDMAN HCWH: Streptomycin in treatment of clinical tuberculosis: A preliminary report, Proc. Staff Meet., Mayo Clinic, 1945, xx, 313-318. Google Scholar3. HINSHAWFELDMANPFUETZE HCWHKH: Treatment of tuberculosis with streptomycin, Jr. Am. Med. Assoc., 1946, cxxxii, 778-782. CrossrefGoogle Scholar4. PFUETZE KH: Personal communication. Google Scholar5. HINSHAW HC: Personal communication. Google Scholar6. FELDMANHINSHAW WHHC: Effects of streptomycin on experimental tuberculosis in guinea pigs: A preliminary report, Proc. Staff Meet., Mayo Clinic, 1944, xix, 593-599. Google Scholar7. AMBERSON JB: The process of resolution in pulmonary tuberculosis, Am. Rev. Tuberc., 1936, xxxiii, 269-301. Google Scholar8. RICH AR: The pathogenesis of tuberculosis, 1944, Charles C. Thomas, Springfield, Illinois, 726. Google Scholar9. BOXERJELINEKDUBOISTOMPSETTEDISON GEJCRRAD: Chemical determination of streptomycin in the blood following intramuscular injection, Jr. Pharm. and Exper. Therap., in press. Google Scholar10. WAKSMANSCHATZ SA: Streptomycin: origin, nature and properties, Jr. Am. Pharm. Assoc. (Sci. ed.), 1945, xxxiv, 273. CrossrefGoogle Scholar11. KELLEYSCADRONSHINNERS WHENBM: Hydrogen ion concentration in exudates of pneumococcus infection, Jr. Exper. Med., 1938, lxvii, 659-665. CrossrefGoogle Scholar12. A preliminary statement concerning the effects of streptomycin upon tuberculosis in man: Office of Chief Medical Director, Veterans' Administration, the Surgeon General of the Army and the Surgeon General of the Navy, Jr. Am. Med. Assoc., 1947, cxxxv, 634. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CARL MUSCHENHEIM, F.A.C.P.; WALSH MCDERMOTT; SUSAN J. HADLEY; HARRIET HULL-SMITH; ALICE TRACYAffiliations: New York, N. Y.*Portions of this study were presented before the annual meetings of: the American College of Physicians, Chicago, April 29, 1947; the American Society for Clinical Investigation, May 5, 1947; and the Section on Internal Medicine of the American Medical Association, June 12, 1947.From the Department of Medicine of the New York Hospital-Cornell University Medical College.The first part of this investigation was conducted under the direction of the National Research Council Committee on Chemotherapeutics and Other Agents, Dr. Chester S. Keefer, Chairman. The subsequent investigation is a part of the Streptomycin Manufacturers American Trudeau Society program which is being conducted in collaboration with the Tuberculosis Study Section of the National Institute of Health. The streptomycin was furnished by the Chemotherapeutic Committee; by a generous donation from Charles Pfizer and Company, Inc., Brooklyn; and from supplies donated to the American Trudeau Society by the Streptomycin Manufacturers.The study was aided in part by grants from the National Institute of Health, and from the Lederle Laboratories, Inc., Pearl River, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe treatment of tuberculosis under current conditionsWalsh McDermott and Changing Conceptions of Tuberculosis Antibiotic TherapyResistenzbestimmung von Tuberkelbakterien gegen Streptomycin, p-Aminosalicylsäure, Conteben, Isonicotinsäurehydrazid und ParatebinAdvances in the Treatment of Bacterial MeningitisSTUDIES ON STREPTOMYCIN-RESISTANT STRAINS OF THE TUBERCLE BACILLUS. I*Tuberculous peritonitis treated with streptomycinTuberculosis in Infants and Children Treated with StreptomycinBed Rest, Collapse, and Streptomycin in the Treatment of Pulmonary TuberculosisCRITERIA FOR THE CLINICAL EVALUATION OF ANTITUBERCULOUS AGENTSReport on Current TherapyThe Value of Streptomycin in the Treatment of TuberculosisINTERMITTENT DOSAGE SCHEDULES OF STREPTOMYCIN WITH RESULTANT PROLONGED SENSITIVITY OF M. TUBERCULOSIS*VERN F. DEYKE, MYRON W. FISHER, LYNN A. JAMES, LEROY J. SIDESPresent Status of Streptomycin In Tuberculosis 1 December 1947Volume 27, Issue 6Page: 989-1027KeywordsChemotherapeutic agentsDrugsMiliary tuberculosisMultidrug resistant tuberculosisRiversStreptococcal infectionsStreptomycinTuberculosis ePublished: 1 December 2008 Issue Published: 1 December 1947 PDF downloadLoading ...