tbuckley/cabot-search huggingface dataset:
ETHYL BROMID ANESTHESIA IN POSTNASAL ADENOID GROWTHS.
Authors: GEORGE MORGENTHAU
Journal: JAMA (1895)

The subjects of "adenoids" is such a well-worn one that I would not venture to bring it before the society, had I not been encouraged in my doubts as to the proper way of operating on these growths, by a recent discussion of this very question at a meeting of the London Laryngological Society. It appeared there, too, how wide is the diversity which exists as to the choice of the anesthetic, the posture of the patient, etc. Since conditions are different with us, especially resulting from the preference given ether over chloroform by the profession at large, and the popular distrust in which the latter drug is held; since, furthermore, this mode of operation with ethyl bromid has not been described in American literature, I am in hopes that the discussion called forth by this short paper will prove to be out of proportion to its length. While it
Effect of acute increases in filtered <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:mrow><mml:msub><mml:mtext>HCO</mml:mtext><mml:mn>3</mml:mn></mml:msub><mml:msup><mml:mrow /><mml:mo>-</mml:mo></mml:msup></mml:mrow></mml:math> on renal hydrogen transporters: II. H+-ATPase
Authors: David A. Maddox, William D. Barnes, F. John Gennari
Journal: Kidney International (1997)
Gender Differences in Survival in Advanced Heart Failure
Authors: Kirkwood F. Adams, Carla A. Sueta, Mihai Gheorghiade, Christopher M. O’Connor, Todd A. Schwartz, Gary G. Koch, Barry Uretsky, Karl Swedberg, William McKenna, Jordi Soler-Soler, Robert M. Califf
Journal: Circulation (1999)

Background —Previous natural history studies in broad populations of heart failure patients have associated female gender with improved survival, particularly in patients with a nonischemic etiology of ventricular dysfunction. This study investigates whether a similar survival advantage for women would be evident among patients with advanced heart failure. Methods and Results —The study analysis is based on the Flolan International Randomized Survival Trial (FIRST) study which enrolled 471 patients (359 men and 112 women) who had evidence of end-stage heart failure with marked symptoms (60% NYHA class IV) and severe left ventricular dysfunction (left ventricular ejection fraction 18±4.9%). A Cox proportional-hazards model, adjusted for age, gender, 6-minute walk, dobutamine use at randomization, mean pulmonary artery blood pressure, and treatment assignment, showed a significant association between female gender and better survival (relative risk of death for men versus women was 2.18, 95% CI 1.39 to 3.41; P &lt;0.001). Although formal interaction testing was negative ( P =0.275), among patients with a nonischemic etiology of heart failure, the relative risk of death for men versus women was 3.08 (95% CI 1.56 to 6.09, P =0.001), whereas among those with ischemic heart disease, the relative risk of death for men versus women was 1.64 (95% CI 0.87 to 3.09, P =0.127). Conclusions —Women with advanced heart failure appear to have better survival than men. Subgroup analysis suggests this finding is strongest among patients with a nonischemic etiology of heart failure.
PLANTAR WART..
Authors: REGINALD HALL
Journal: British Journal of Dermatology (1957)

Journal Article PLANTAR WART.: Recurrence After Curettage Under Local Anaesthesia. Get access REGINALD HALL, M.D., E.R.C.P.I. REGINALD HALL, M.D., E.R.C.P.I. Consultant Dermatologist, Royal Victoria Hospital, Belfast Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 3, 1 March 1957, Pages 95–96, https://doi.org/10.1111/j.1365-2133.1957.tb13237.x Published: 01 March 1957
Evidence for attenuation of myo-inositol uptake, phosphoinositide turnover and inositol phosphate production in aortic vasculature of rats during pregnancy.
Authors: K P Conrad, S A Barrera, P A Friedman, V M Schmidt
Journal: Journal of Clinical Investigation (1991)

We postulated that vascular phosphoinositide metabolism is attenuated during pregnancy, and thereby could contribute to maternal vasodilation and reduced vascular reactivity. The basal rate of incorporation of [3H]myo-inositol and [3H]glycerol into phosphoinositides of aortae from pregnant rats in vitro was significantly reduced, when compared with vessels from virgin animals. After injection of [3H]myo-inositol intravenously into chronically instrumented conscious pregnant and virgin rats, the incorporation of the label by phosphatidylinositol was 66 +/- 4% less in aortae of gravid versus virgin animals (P less than 0.001), despite comparable plasma concentrations of radioactivity. Fold stimulation of total [3H]inositol phosphates by arginine vasopressin, norepinephrine, and angiotensin II over a 15-min period was not different between aortic segments from virgin and gravid rats, although both absolute basal and stimulated levels were significantly less in vessels from pregnant animals. After 45 s of incubation with 10(-7) M arginine vasopressin, however, the fold-stimulation of [3H]inositol trisplus tetrakisphosphate was reduced in aortae from gravid rats, when compared with vessels from virgin animals (P less than 0.005). By HPLC, greater than 90% of the radioactivity in the [3H]inositol trisplus tetrakisphosphate column fraction after 30 and 60 s of agonist stimulation was [3H]inositol-1,4,5-trisphosphate. We further observed that the rate of uptake of [3H]myo-inositol by aortic vasculature obtained from gravid rats was significantly (24%) less than uptake by vessels from virgin animals. Plasma myo-inositol concentrations were not significantly different, but presumably as a consequence of reduced uptake, aortic segments freshly isolated from pregnant rats contained 22 +/- 6% less myo-inositol than vessels from virgin controls as measured by gas chromatography-mass spectrometry (P less than 0.03). We conclude that myo-inositol uptake and content, phosphoinositide turnover, and inositol phosphate production are reduced in aortic vasculature of gravid rats.
169 FORMULATION AND EVALUATION OF ATP-CONTAINING LIPOSOMES INCLUDING LACTOSYLATED ASGPR LIGAND TO ENHANCE CELLULAR ENERGY STATUS FOR HEPATIC APPLICATIONS
Authors: V. Vincourt, K. Tep, V. Korb, C. Richard, V. Escriou, C. Largeau, D. Scherman, L. Cynober, J.C. Chaumeil, G. Dumortier
Journal: Journal of Hepatology (2009)
Cost and Benefit
Authors: M. A. Baltzan
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 August 1973Cost and BenefitM. A. Baltzan, M.D.M. A. Baltzan, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-2-281 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the April 1973 issue (p. 580), in the excerpt "'Cost/Benefit' in Medicine" from The Medical Journal of Australia, I was particularly interested in the last sentence, "Is the benefit worth this cost to the community?" This question directly points up a dilemma that must constantly be faced by those of us who practice under comprehensive government-financed medical care and hospital care insurance schemes. In our decision-making we must constantly ask ourselves the question, "To whom are we responsible, the insurance agency or the patient?"Refusal to carry out a kidney transplantation because of cost to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1973Volume 79, Issue 2Page: 281-282KeywordsRenal transplantation Issue Published: 1 August 1973 PDF DownloadLoading ...
HIGHER INTRAMYOCARDIAL HOMING IS ASSOCIATED WITH BETTER CLINICAL RESPONSE TO CD34+ CELL THERAPY IN NONISCHEMIC DILATED CARDIOMYOPATHY PATIENTS
Authors: Bojan Vrtovec, Gregor Poglajen, Luka Lezaic, Matjaz Sever, Francois Haddad, Joseph C. Wu
Journal: Journal of the American College of Cardiology (2013)
Abstract 4294: Using the zebrafish model to determine the role of the HACE1 tumor suppressor in apoptosis, cell proliferation and development
Authors: Lindsay A. McDonald, Sahar Da'as, Paul D'Alessandro, Poul H. Sorensen, Jason N. Berman
Journal: Cancer Research (2011)

Abstract HACE1 is a novel tumor suppressor gene located at human chromosome 6q21. HACE1 possesses both ankyrin repeats and a catalytically active HECT domain. HACE1 is downregulated in a variety of human cancers including Wilms’ tumor, melanoma, breast cancer, lung cancer, lymphoma, and colon cancer, thus representing a potentially broadly applicable genetic target. While HACE1 is widely expressed in human tissues, its role in normal development remains unknown. The zebrafish has established itself as a robust model for studying vertebrate development and modeling human cancers by virtue of conserved genetics and direct evaluation of gene expression through imaging afforded by transparent embryos. A zebrafish hace1 homologue has been identified. Whole mount in situ hybridization (WISH) assays with probes to the ankyrin repeats and HECT domains demonstrate expression of zebrafish hace1 in heart, brain and kidney at early developmental time points (24 hours post-fertilization (hpf) – 7 days post-fertilization (dpf)), consistent with human expression. WISH studies in wild type embryos, employing probes to the zebrafish hace1 HECT domain and cmcl2 (heart) or cdh17 (kidney), show co-localization at early developmental time points. Moreover, morpholino knockdown of hace1 in cmcl2-GFP transgenic embryos reveals severely perturbed cardiac development and function beginning at 48 hpf, further implicating this gene in normal vertebrate cardiac development. We have also generated two transgenic zebrafish lines harboring either wild type or dominant negative mutated C876S (C876S DN) human HACE1 genes with a green fluorescent protein (GFP) tag under the control of the ubiquitous β-actin promoter. Compared to wild type embryos, we observed increased apoptosis in 28 hpf C876S DN by acridine orange and caspase 3 assays, both untreated and following irradiation-induced cellular damage. There was no statistically significant difference in cellular proliferation between wild type embryos and C876S DN by 5-bromo-2-deoxyuridine (BrdU) incorporation (p=0.18). These results suggest that loss of HACE1 function alone is not sufficient to lead to a dysregulated cellular proliferation and implicate additional genetic lesions, such as p53 in tumor formation. C876S DN transgenic zebrafish are being crossed with p53 mutated zebrafish in order to determine the combined effect of both mutations on apoptosis, cell proliferation, and tumor formation. Further characterization of the HACE1 transgenic zebrafish model will serve to better our understanding of the role of human HACE1 in normal development and tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4294. doi:10.1158/1538-7445.AM2011-4294
ADVANCES IN POLIOMYELITIS IMMUNIZATION
Authors: Leroy E. Burney
Journal: JAMA (1961)

All of us can agree that in the United States we have come a long way toward controlling paralytic poliomyelitis. Within the past 5 years, some 93 million persons have used the Salk vaccine, and 78 million of them are now fully immunized. This is a monumental achievement in preventive medicine. I know of no parallel in medical history. For this the medical and public health professions, the National Foundation, dozens of other organizations and thousands of individuals deserve great and enduring credit. During these 5 years, there have not only been many improvements in the inactivated vaccine, but a marked increase in potency has been achieved. Steady progress has also been made in the development of oral vaccines. Dr. Hilary Koprowski of the Wistar Institute in Philadelphia, Dr. Herald Cox of the Lederle Laboratories, and Dr. Albert Sabin of the University of Cincinnati have been world leaders in this
Vasculopathy, inflammation, and blood flow in leg ulcers of patients with sickle cell anemia
Authors: Caterina P. Minniti, Kara‐Marie H. Delaney, Alexander M. Gorbach, Dihua Xu, Chyi‐Chia Richard Lee, Nitin Malik, Antony Koroulakis, Matthew Antalek, Jordan Maivelett, Marlene Peters‐Lawrence, Enrico M. Novelli, Sophie M. Lanzkron, Karen C. Axelrod, Gregory J. Kato
Journal: American Journal of Hematology (2013)

Chronic leg ulcers are frequent and debilitating complications of sickle cell anemia. Inadequate blood supply has been postulated to be an important factor in their occurrence and delayed healing. Little is known about their microcirculatory and histopathological changes. We evaluated the microcirculation of lower extremity ulcers with laser speckle contrast imaging and infrared thermography and obtained clinical and laboratory characteristics in 18 adults with sickle cell anemia and chronic leg ulcers. Skin biopsies were obtained in four subjects. Subjects had markers of severe disease, anemia, high degree of hemolysis, inflammation, and thrombophilia. The highest blood flow was present in the ulcer bed, progressively less in the immediate periwound area, and an unaffected control skin area in the same extremity. Microscopic examination showed evidence of venostasis, inflammation, and vasculopathy. Blood vessels were increased in number, had activated endothelium and evidence of thrombosis/recanalization. High blood flow may be due to chronic inflammation, cutaneous vasodilatation, venostasis, and in situ thrombosis. These changes in skin microcirculation are similar to chronic venous ulcers in the non-sickle cell disease (SCD) population, thus suggesting that leg ulcers may be another end-organ complication with endothelial dysfunction that appears in patients with SCD at a younger age and with higher frequency than in the general population.
Acetone Poisoning after Applying Light-weight Cast
Authors: P. K. Renshaw, R. M. Mitchell
Journal: BMJ (1956)

Multiple crystallization of insulin leads to a striking reduc- tion in reactions, but the dermal reacting factor in insulin has not been identified by fractionization methods.I am at a loss to explain the severe reaction shown by this patient, but the case appears to be worth reporting because of the response.A point of particular interest is that, by accident, she received a further injection of I.Z.S. four weeks after her recovery, and showed no reaction on this occasion.
Collagen Diseases, Hepatitis-Associated Antigen, and The Epstein-Barr Virus
Authors: John K. Miller
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The search for a causal relation between collagen diseases and auto-immune systems has extended to two new antigen-antibody complexes. Epstein-Barr virus (EBV) antibodies in sera of patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)<sup>1</sup>have been reported. Hepatitis-associated antigen (HAA) has been found in sera of patients with polyarteritis nodosa (PAN),<sup>2</sup>RA,<sup>3</sup>and SLE.<sup>4</sup>Gocke and co-workers<sup>2</sup>demonstrated by immunofluorescence an immune complex of HAA, IgM globulin, and β complement in a biopsy from the arterial wall of a patient with PAN. It is well known that arthralgia and clinical arthritis occur in the prodromal period of viral hepatitis. Sera from 54 patients with collagen disease were tested for EBV antibodies by the method of Henle and Henle,<sup>5</sup>for HAA by immunoelectrophoresis (cellulose acetate membrane), and by the hemagglutination assay of Vyas and Shulman.<sup>6</sup> The Table summarizes the
Polymorphism 4G/5G in the plasminogen activator inhibitor‐1 (PAI‐1) gene is associated with IgE‐mediated allergic diseases and asthma in the Czech population
Authors: D. Buč, L. Izakovičová Hollá, J. Vácha
Journal: Allergy (2002)

Background: Plasminogen activator inhibitor type 1 (PAI‐1) is a glycoprotein that belongs to the serine protease inhibitor superfamily and has an essential role in tissue remodeling after inflammation. Recently, a single base pair deletion/insertion (4G/5G) polymorphism of the PAI‐1 gene has been associated with an increased risk of asthma in nuclear families from the UK. Methods: The present study was thus conducted to determine the association of this polymorphism with the development of IgE‐mediated asthma and other allergic diseases in the Czech population. A case‐control approach was used in our study. DNA taken from subjects with clinically manifested asthma and other allergic diseases ( n = 207) and from reference ethnically age‐gender‐matched unrelated subjects ( n = 186) was examined for base deletions/insertions in the PAI‐1 gene. Results: A significant association ( P = 0.0035) was observed between the PAI‐1 promoter polymorphism and IgE‐mediated allergic diseases altogether. Furthermore, the 4G allele frequency was also significantly higher in the asthmatic patients than in the control group ( P = 0.0148). Conclusions: Our findings support the idea that the 4G allele of the 4G/5G polymorphism in the PAI‐1 gene may be a risk factor for IgE‐mediated asthma and allergic diseases.
Cutaneous elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin
Authors: A. Geusau, E. Tschachler, M. Meixner, O. Papke, G. Stingl, M. Mclachlan
Journal: British Journal of Dermatology (2001)

Journal Article Cutaneous elimination of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin Get access A. Geusau, A. Geusau Alexandra Geusau. E‐mail: alexandra.geusau@akh‐wien.ac.at Search for other works by this author on: Oxford Academic Google Scholar E. Tschachler, E. Tschachler Search for other works by this author on: Oxford Academic Google Scholar M. Meixner, M. Meixner Search for other works by this author on: Oxford Academic Google Scholar O. Päpke, O. Päpke ERGO Forschungsgesellschaft, Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar G. Stingl, G. Stingl Search for other works by this author on: Oxford Academic Google Scholar M. Mclachlan M. Mclachlan Baltic Sea Research Institute, Rostock, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 6, 1 December 2001, Pages 938–943, https://doi.org/10.1046/j.1365-2133.2001.04540.x Published: 01 December 2001
Re: Anders Lidgren, Ylva Hedberg, Kjell Grankvist, Torgny Rasmuson, Anders Bergh and Börje Ljungberg. Hypoxia-Inducible Factor 1α Expression in Renal Cell Carcinoma Analyzed by Tissue Microarray. Eur Urol 2006;50:1272–7
Authors: Andrea Minervini, Claudio Di Cristofano, Sergio Serni, Marco Carini
Journal: European Urology (2007)
RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS
Authors: GeorgeH Mccracken, MaryP Glode, LarrieD Sarff, SusanG Mize, MarkS Schiffer, JohnB Robbins, EmilC Gotschlich, Ida Orskov, Frits Orskov
Journal: The Lancet (1974)
No 1,25-dihydroxyvitamin D3 receptors on osteoclasts of calcium-deficient chicken despite demonstrable receptors on circulating monocytes.
Authors: J Merke, G Klaus, U Hügel, R Waldherr, E Ritz
Journal: Journal of Clinical Investigation (1986)

1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is known to stimulate osteoclastic bone resorption in vivo and whole organ bone culture systems in vitro. It has not been established whether 1,25(OH)2D3 acts directly on osteoclasts or whether its action on osteoclasts is mediated via other bone cells (e.g., osteoblasts) or recruitment of osteoclast precursor cells. Circulating monocytes have been characterized as osteoclast precursors. In the present study, vitamin D3-replete chicken on a calcium-deficient diet were studied. Circulating monocytes, whole bone cell preparations, and isolated osteoclasts (differential sedimentation) were examined for presence of 1,25(OH)2D3 receptors. Reversible, specific, and saturable binding of [3H]-1,25(OH)2D3 to a 3.5 S macromolecule was demonstrated in nuclear fractions of monocytes (maximal binding capacity, 48 fmol/mg protein; dissociation constant, 1.3 X 10(-10) M) and of whole bone cell preparations. 1,25(OH)2D3 receptors were not demonstrable in osteoclast preparations (70% pure; detection threshold, 2 fmol/mg protein). Data are consistent with indirect action of 1,25(OH)2D3 on osteoclastic bone resorption.
Long-lasting, specific immunologic unresponsiveness associated with cryptococcal meningitis.
Authors: D K Henderson, J E Bennett, M A Huber
Journal: Journal of Clinical Investigation (1982)

A sensitive radioimmunoassay and an antibody class-specific enzyme-linked immunosorbent assay were used to determine whether patients cured of cryptococcosis responded normally to immunization with cryptococcal capsular polysaccharide (CPS) and type III pneumococcal polysaccharide. 10 normal volunteers and 8 patients who had been cured of cryptococcal meningitis and who had been cured of cryptococcal meningitis and who had no serious underlying diseases were immunized with both antigens. Geometric mean titers to CPS measured by radioimmunoassay were 1:1 in both groups before vaccination, but were 1:3 in patients and 1:119 in controls following immunization (P less than 0.01, Student's t test). Analysis of the class-specific response to immunization with CPS found little anti-CPS IgG or IgA. Geometric mean postvaccination IgM titers were 1:31 in patients and 1:238 in controls (P less than 0.01). Responses to immunization with type III pneumococcal polysaccharide were similar in patients and controls, with IgA, IgM, and IgG mean titers of 1:1129, 1:369, and 1:158 in patients and 1:1504, 1:1039, and 1:163 in controls (P greater than 0.2 for each antibody class). Cured cryptococcal meningitis is often associated with prolonged specific immunologic unresponsiveness.
Respiratory Disability in Coal Miners
Authors: Leon Cander
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Perhaps because of the difficulties inherent in disability evaluation, the subject of respiratory disability among coal miners has rarely been marked by calm, dispassionate presentation. Morgan et al (1980;243:2401) argue that arterial blood gas analyses are unnecessary in the evaluation of the condition of claimants under the federal black lung program. In addition to possibly representing a survivor group, it is questionable whether the authors' sample of bituminous coal miners was representative of coal miners from the anthracite fields of northeastern Pennsylvania and the coal fields of the western states. Of greater import is the authors' failure to distinguish clearly between different definitions of illness—between the administrative-clinical black lung and the clinical-pathological coal workers' pneumoconiosis (CWP). The effects of lung injury are frequently additive, and because it is virtually impossible to distinguish among the various causes of lung injury (including cigarette smoking) and resultant pulmonary insufficiency