tbuckley/cabot-search huggingface dataset:
Glucocorticoid Receptor [gr] Translocation Regulation by Inflammatory Cytokines
Authors: N. Bulayeva, B.T. Ameredes, W.J. Calhoun
Journal: Journal of Allergy and Clinical Immunology (2007)

RATIONALE: Non-caseating granulomatous disease is well-described in common variable immunodeficiency (CVID).It classically presents as a sarcoid-like illness with multi-organ or cutaneous involvement.METHODS: We present a fifty two year old female with a seventeen year history of CVID presenting with lip swelling of six weeks duration and bilateral submandibular adenopathy.She was on a self-imposed hiatus from gammaglobulin therapy for six months.Environmental history is significant for cats in the home.She was treated with prolonged antibiotic therapy for presumed infectious etiology.Antibiotics did not resolve her symptoms.RESULTS: Clinical evaluation revealed lip swelling consistent with angioedema and submandibular adenopathy without airway compromise.A CT of the neck showed adenopathy without signs of abscess.Laboratory evaluation revealed low IgG (465 mg/dL) and IgA (31 mg/dL) and lymphopenia with an absolute lymphocyte count of 539/uL.Normal levels of C4, CH50 and C1 esterase inhibitor.Angiotensin converting enzyme within normal range.Bartonella IgG and IgM titers were negative.A tissue biopsy of the lip and submandibular node revealed non-necrotizing granulomas and a negative AFB stain.A CT of the chest, abdomen and pelvis revealed hepatosplenomegaly.Bone marrow biopsy was negative for granulomas and neoplastic disease.CONCLUSIONS: Multi systemic granulomatous disease is a recognized complication of CVID.It is associated with significant morbidity and early mortality.We describe a patient with known CVID and newly diagnosed granulomatous disease presenting as angioedema.This case illustrates the importance of considering persistent soft tissue swelling as an initial presentation of granulomatous disease in a patient with CVID.
Chrysotile Asbestos and Mesothelioma
Authors: Richard A. Lemen
Journal: Environmental Health Perspectives (2010)

Assuming an average latency of 42 years, the authors predict that incidence rates will peak in 2009 and that diagnoses will peak in 2014.However, they caution that ongoing use of chrysotile asbestos (which has been implicated but not conclusively established as a cause of mesothelioma) and the release of asbestos fibers from older buildings during demolition or reno vation may slow the projected decline.
Polymorphic Ventricular Tachycardia and Repolarization Abnormalities Accompanying Intracerebral Hemorrhage
Authors: Haim D. Danenberg, Yonathan Hasin
Journal: Circulation (2000)

A 70-year-old patient with no apparent heart disease was admitted after a motor-vehicle accident and had right hemispheric intracerebral hemorrhage with compression over the lateral ventricle (Figure 1).The patient was admitted to an intensive care unit, where an ECG was taken.ECG repolarization abnormalities were followed by repeated runs of nonsustained polymorphic ventricular tachycardia (torsade de pointes) (Figure 2), which caused hemodynamic instability.Intravenous magnesium sulfate was administered, and the ECG changes subsided promptly (Figure 3).An exercise test performed a few weeks later was negative for ischemia.Life-threatening arrhythmias, including atrioventricular blocks, ventricular tachycardia, and fibrillation, may accompany acute cerebral accidents in patients without cardiac disease.Therefore, after acute cerebrovascular events, patients should be constantly monitored, and the treating team should be familiar with and well-trained in the diagnosis and treatment of cardiac arrhythmias.
Dose-dependent effectiveness of ciclesonide nasal spray in the treatment of seasonal allergic rhinitis (SAR)*1
Authors: P.H. Ratner, J.H. van Bavel, F. Hampel, M.A. Wingertzahn, P.F. Darken, T. Shah, S. Hellbardt, S. Brookman
Journal: Journal of Allergy and Clinical Immunology (2004)
Updating the management of patients with rectal neuroendocrine tumors
Authors: Louis de Mestier, Hedia Brixi, Rodica Gincul, Thierry Ponchon, Guillaume Cadiot
Journal: Endoscopy (2013)

Rectal neuroendocrine tumors (NETs) account for approximately one-third of all digestive NETs, with an increasing incidence and good overall prognosis. Although recent guidelines have been published, endoscopic techniques have expanded substantially and the most recent reports should be taken into account for clinical practice. The objectives of this report were to review the latest advances on prognosis, pre-interventional explorations, treatment – with particular focus on endoscopy – and surveillance of well-differentiated rectal NETs, excluding poorly differentiated and metastatic tumors.
A Chair of Ethics in Medical Colleges.
Authors: J. F. Tracy
Journal: JAMA (1898)

Toledo, Ohio, Aug. 15, 1898. <h3>To the Editor:</h3> —It goes with the saying that medical colleges are very largely responsible for conditions existing in the medical profession. Conditions, as used above, include many things, and the word "responsible," in this same sentence, points prideward as well as in the opposite direction. One condition, as the word is used, is the general intelligence of the medical profession; another, the standard of medical knowledge which maintains, while professional honor, honesty, morality, etc., are others. Medical colleges are alike responsible for the highest grade in learning, uprightness and respectability, for example, as they are for the lowest grades in the same spheres. Naturally one looks for a college-bent principle to lean in the same direction throughout life, and the expectation is usually realized. There is among some members of the profession a positive antagonism to the "Code of Ethics." That antagonism had
642 Chlamydia pneumoniae liver gene expression and anti-chlamydial antibody response in patients with primary biliary cirrhosis
Authors: D.P Bogdanos, C. Liaskos, S. Leoni, K. Steinhagen, S. Arora, H.M. Smith, M.A. Heneghan, H. Baum, W. Meyer, D. Vergani
Journal: Journal of Hepatology (2006)
Bone Mineral Density Among Premenopausal Women With Early Breast Cancer in a Randomized Trial of Adjuvant Endocrine Therapy
Authors: Á. Sverrisdóttir, T. Fornander, H. Jacobsson, E. von Schoultz, L.E. Rutqvist
Journal: Journal of Clinical Oncology (2004)

Purpose To examine the effects on bone mineral density of 2 years of treatment with a luteinizing hormone-releasing hormone (LHRH) agonist alone or in combination with tamoxifen or tamoxifen alone in premenopausal breast cancer. Patients and Methods We recruited 89 women from two centers in Stockholm participating in a randomized multicenter trial of three different endocrine approaches in the adjuvant setting (Zoladex in Premenopausal Patients Trial). The women were assigned to receive the LHRH agonist goserelin with or without tamoxifen, tamoxifen alone, or no endocrine therapy. The treatment was given for 2 years. We measured total-body bone density before start of treatment and at 12, 24, and 36 months. Results After 2 years of treatment, there was a significant loss of bone mineral density (mean change, −5%; P &lt; .001) in the women receiving goserelin alone. The combined goserelin and tamoxifen treatment, as well as tamoxifen alone, resulted in a lesser but statistically significant decline in bone mineral density (mean change, −1.4%; P = .02; and −1.5%; P &lt; .001). One year after cessation of treatment, the goserelin group alone showed a partial recovery from bone loss (mean change, 1.5%; P = .02). Conclusion Two years of ovarian ablation from goserelin treatment caused a significant reduction in bone mineral density but there was a partial recovery from the bone loss 1 year after cessation of treatment. The addition of tamoxifen seems to partially counteract the demineralizing effects of goserelin.
Health secretary tells NHS in England to sell land and use fewer agency staff and management consultants
Authors: M. Limb
Journal: BMJ (2014)

England’s health secretary, Jeremy Hunt, has called for the NHS to find a further £10bn (€13bn; $16bn) in savings by 2020 and radically rethink the way it spends money. He said this could be achieved under a new “compact” with health bodies, translated into local agreements between organisations and their staff.

Hunt said that the money saved would contribute to the £22bn efficiency savings earmarked in the NHS Five Year Forward View launched recently by the NHS’s chief executive, Simon Stevens.1 2

Hunt announced the savings plan in a speech to the annual conference of the health think tank the King’s Fund in London on 13 November. He proposed cutting the NHS’s spiralling bill for temporary agency staff and spending less on administration, management consultants, healthcare of migrants, and unused drugs. He said that more had to be done to limit prescribing errors and avert preventable …
Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: An open-label, multicenter study
Authors: Carlos Alberto Aguilar-Salinas, Guillermo Fangh[auml ]nel-Salm[oacute]n, Edilberto Meza, Juan Montes, Alfonso Gul[iacute]as-Herrero, Leticia S[aacute]nchez, Eric A. Monterrubio-Flores, H[eacute]ctor Gonz[aacute]lez-Valdez, Francisco J.G[oacute]mez P[eacute]rez
Journal: Metabolism (2001)
NUCLEOSIDE TRIPHOSPHATASE IN LANGERHANS CELLS OF AITTOLYTIC SKI N
Authors: P. O. FRITSCH, F. G. SCHELLANDER
Journal: British Journal of Dermatology (1971)

SUMMARY.— The nucleoside triphosphatase activity of epidermal Langerhans cells was studied in autolytic skin. Enzyme activity could be seen up to 2 days in specimens incubated at 37° C. and up to 26 days in specimens incubated at 4° C. It is pointed out that this histochemical staining method seems to be very stable and not confined to a special and transitory functional state of this cell system. It is concluded that this method could possibly be used as a marker for the identification of Langerhans cells under in vitro conditions.
Liver transplantation in the human immunodeficiency virus-hepatitis C virus coinfected patient: Time to sum up
Authors: Didier Samuel, Jean-Charles Duclos-Vallee, Roberto J. Groszmann, Yasuko Iwakiri, Tamar H. Taddei
Journal: Hepatology (2013)

Hepatitis C virus (HCV) is a controversial indication for liver transplantation (LT) in human immunodeficiency virus (HIV)–infected patients because of reportedly poor outcomes. This prospective, multicenter US cohort study compared patient and graft survival for 89 HCV/HIV-coinfected patients and 2 control groups: 235 HCV-monoinfected LT controls and all US transplant recipients who were 65 years old or older. The 3-year patient and graft survival rates were 60% [95% confidence interval (CI) = 47%-71%] and 53% (95% CI = 40%-64%) for the HCV/HIV patients and 79% (95% CI = 72%-84%) and 74% (95% CI = 66%-79%) for the HCV-infected recipients (P < 0.001 for both), and HIV infection was the only factor significantly associated with reduced patient and graft survival. Among the HCV/HIV patients, older donor age [hazard ratio (HR) = 1.3 per decade], combined kidney-liver transplantation (HR = 3.8), an anti-HCV–positive donor (HR = 2.5), and a body mass index <21 kg/m2 (HR = 3.2) were independent predictors of graft loss. For the patients without the last 3 factors, the patient and graft survival rates were similar to those for US LT recipients. The 3-year incidence of treated acute rejection was 1.6-fold higher for the HCV/HIV patients versus the HCV patients (39% versus 24%, log rank P = 0.02), but the cumulative rates of severe HCV disease at 3 years were not significantly different (29% versus 23%, P = 0.21). In conclusion, patient and graft survival rates are lower for HCV/HIV-coinfected LT patients versus HCV-monoinfected LT patients. Importantly, the rates of treated acute rejection (but not the rates of HCV disease severity) are significantly higher for HCV/HIV-coinfected recipients versus HCV-infected recipients. Our results indicate that HCV per se is not a contraindication to LT in HIV patients, but recipient and donor selection and the management of acute rejection strongly influence outcomes.
Performance status of health care facilities changes with risk adjustment of HbA1c.
Authors: Q Zhang, M Safford, J Ottenweller, G Hawley, D Repke, J F Burgess, S Dhar, H Cheng, H Naito, L M Pogach
Journal: Diabetes Care (2000)

OBJECTIVE: To develop a risk adjustment method for HbA1c, based solely on administrative data and to determine the extent to which risk-adjusted HbA1c changes the identification of high- or low-performing medical facilities. RESEARCH DESIGN AND METHODS: Through use of pharmacy records, 204,472 diabetic patients were identified for federal fiscal year 1996 (FY96). Complete information (HbA1c levels, demographic data, inpatient records, outpatient pharmacy utilization records) was available on 38,173 predominantly male patients from 48 Veterans Health Administration (VHA) medical facilities. Hierarchical mixed-effects models were used to estimate risk-adjusted unique facility-level HbA1c. RESULTS: Predicted HbA1c demonstrated expected patterns for major factors known to influence glycemic control. Poorer glycemic control was seen in minorities and patients with greater disease severity, longer duration of disease (using treatment type or presence of amputation as surrogates), and more extensive comorbidity (measured by an adapted Charlson index). Better glycemic control was seen in Caucasians, older diabetic patients, and patients with higher outpatient utilization. The number of performance outliers was reduced as a result of risk adjustment. For mean HbA1c levels, 7 facilities that were initially identified as statistically significant outliers were no longer outliers after risk adjustment. For high-risk HbA1c (&amp;gt;9.5%) rates, 12 facilities that were initially identified as statistically significant outliers were no longer outliers after risk adjustment. CONCLUSIONS: Risk adjustment using only administrative data resulted in substantial changes in identification of high or low performers compared with non-risk-adjusted HbA1c. Although our findings are exploratory, risk adjustment using administrative data may be a necessary and achievable step in quality assessment of diabetes care measured by rates of high-risk HbA1c (&amp;gt;9.5%).
Bad medicine: thyroid disease
Authors: D. Spence
Journal: BMJ (2012)

Our sense of wellness is one of nature’s greatest gifts to humanity. A recent review has confirmed huge overdiagnosis of breast cancer through screening. So, over the past 20 years 80 000 women in the UK (equivalent to every person eligible for screening in Edinburgh) have been falsely diagnosed with cancer, enduring surgery and chemotherapy.1 This is the theft of wellness on the grandest of scales. Overdiagnosis is everywhere,2 and a problem still hugely underappreciated.⇑

Are we overdiagnosing thyroid disease? Subclinical hypothyroidism is where thyroid hormone …
Renal Colic and Anuria from Acetazolamide
Authors: J. G. Yates-Bell
Journal: BMJ (1958)

Recommendations to reduce the risk of side-effects from atropinization of the eye have included the use' of a 0.5% solution, precautions to avoid concentration of the solution by evaporation, and compression of the internal angle of the eye to obstruct the lacrimal duct during instillation (Belz, 1949; Fleury and Marx, 1949).It would be interesting to know if any positive correlation could be found between the more minor emotional disturbances and restlessness which often accompany eye surgery, and any particular dosage or method of atropine administra- tion.
Clinician's Manual on Management Issues in Gastro-esophageal Reflux Disease
Authors: A IRELAND
Journal: Gut (2001)

Clinician's Manual on Management Issues in Gastro-esophageal Reflux Disease . Edited by JJ Misiewicz (Pp 66; illustrated; £11.95) UK: Science Press. ISBN 1-85873-353-7.

I started reading this book not entirely sure whose bookshelf it was designed to be placed on. It is written largely by mainland European gastroenterologists, with one American contribution, and most contributors will be unfamiliar to British readers. The first chapter gets off to an inauspicious start, being in a very stilted language style and giving a rather simplistic …
Herpes Zoster Ophthalmicus: Comparison of Disease in Patients 60 Years and Older Versus Younger than 60 Years
Authors: Neelofar Ghaznawi, Ajoy Virdi, Amir Dayan, Kristin M. Hammersmith, Christopher J. Rapuano, Peter R. Laibson, Elisabeth J. Cohen
Journal: Ophthalmology (2011)
Low-dose recombinant interferon-α in the treatment of cutaneous T-cell lympbomas
Authors: B. Dreno, W.Y. Godefroy, M. Fleischmann, B. Bureau, P. Lioutx
Journal: British Journal of Dermatology (1989)

Journal Article Low‐dose recombinant interferon‐α in the treatment of cutaneous T‐cell lympbomas Get access B. Dreno, B. Dreno Department of Dermatology, Hotel Dieu, 44035 Nantes Cedex OI, France Search for other works by this author on: Oxford Academic Google Scholar W.Y. Godefroy, W.Y. Godefroy Laboratoire Eli Lilly, 203 Bureaux de la Colline, 92213 Saint Cloud, France Search for other works by this author on: Oxford Academic Google Scholar M. Fleischmann, M. Fleischmann Department of Dermatology, Hotel Dieu, 44035 Nantes Cedex OI, France Search for other works by this author on: Oxford Academic Google Scholar B. Bureau, B. Bureau Department of Dermatology, Hotel Dieu, 44035 Nantes Cedex OI, France Search for other works by this author on: Oxford Academic Google Scholar P. Lioutx P. Lioutx Department of Dermatology, Hotel Dieu, 44035 Nantes Cedex OI, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 4, 1 October 1989, Pages 543–544, https://doi.org/10.1111/j.1365-2133.1989.tb15526.x Published: 01 October 1989
Consultant who accused himself of sexual misconduct is struck off
Authors: C. Dyer
Journal: BMJ (2014)

A consultant in genitourinary medicine who forged a series of anonymous letters accusing himself of sexual misconduct has been struck off by a fitness to practise panel.

Kendon MacDonald, 39, called himself a “disgusting pervert” and “sex pest” in letters sent to staff at two NHS trusts, local general practices, the National Patient Safety Agency, and the General Medical Council. The letters were written “to create an impression that individuals sought to pursue a vendetta against him,” a panel of the Medical Practitioners Tribunal Service found.

MacDonald began writing the letters in 2010, shortly after being suspended from his consultant post at Salisbury District Hospital when a patient complained that …
Filling patterns in left ventricular hypertrophy: A combined acoustic quantification and Doppler study
Authors: Adrian Chenzbraun, Fausto J. Pinto, Shawn Popylisen, Ingela Schnittger, Richard L. Popp
Journal: Journal of the American College of Cardiology (1994)

Objectives. The purpose of this study was to evaluate the potential of acoustic quantification compared with Doppler echocardiography for assessment of left ventricular diastolic dysfunction. Background. Diastolic dysfunction usually accompanies left ventricular hypertrophy. Although Doppler echocardiography is widely used, it has known limitations in the diagnosis of diastolic abnormalities. The ventricular area-change waveform obtained with acoustic quantification technology may provide an alternative to assess diastolic dysfunction. Methods. Potential acoustic quantification variables (peak rate of area change and mean slope of area change rate during rapid filling, amount of relative area change during rapid filling and atrial contraction) were obtained and compared with widely used Doppler indexes of ventricular filling (isovolumetric relaxation time, pressure half-time, peak early diastolic velocity/peak late diastolic velocity ratio, rapid filling, atrial contribution to filling) ia 16 healthy volunteers and 30 patients with left ventricular hypertrophy. Results. Criteria for abnormal relaxation were present in 68% of patients by acoustic quantification and in 64% of patients by Doppler echocardiography. However, abnormal relaxation was identified in 89% of patients by one or both methods. Acoustic quantification indicated abnormal relaxation in the presence of completely normalized Doppler patterns and in patients with mitral regurgitation or abnormal rhythm with unreliable Doppler patterns. Conclusions. Acoustic quantification potentially presents a new way to assess diastolic dysfunction. This technique may be regarded as complementary to Doppler echocardiography. The combined use of the methods may improve the diagnosis of left ventricular relaxation abnormalities.
Comprehensive genomic access to vector integration in clinical gene therapy
Authors: Richard Gabriel, Ralph Eckenberg, Anna Paruzynski, Cynthia C Bartholomae, Ali Nowrouzi, Anne Arens, Steven J Howe, Alessandra Recchia, Claudia Cattoglio, Wei Wang, Katrin Faber, Kerstin Schwarzwaelder, Romy Kirsten, Annette Deichmann, Claudia R Ball, Kamaljit S Balaggan, Rafael J Yáñez-Muñoz, Robin R Ali, H Bobby Gaspar, Luca Biasco, Alessandro Aiuti, Daniela Cesana, Eugenio Montini, Luigi Naldini, Odile Cohen-Haguenauer, Fulvio Mavilio, Adrian J Thrasher, Hanno Glimm, Christof von Kalle, William Saurin, Manfred Schmidt
Journal: Nature Medicine (2009)
Pulmonary Lesions of Kaposi's Sarcoma, Intra-alveolar Hemorrhage, and Pleural Effusion
Authors: JEAN L. TOUBOUL
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 November 1985Pulmonary Lesions of Kaposi's Sarcoma, Intra-alveolar Hemorrhage, and Pleural EffusionJEAN L. TOUBOUL, M.D., CHARLES M. MAYAUD, M.D., PIERRE FOURET, M.D., GEORGES M. AKOUN, M.D.JEAN L. TOUBOUL, M.D.Search for more papers by this author, CHARLES M. MAYAUD, M.D.Search for more papers by this author, PIERRE FOURET, M.D.Search for more papers by this author, GEORGES M. AKOUN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-5-808_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to comment on the interesting article by Dr. Ognibene and associates (1) on pulmonary impairment induced by Kaposi's sarcoma in patients with the acquired immunodeficiency syndrome (AIDS).First, in our experience with 78 bronchoalveolar lavage fluid samples from 60 patients with AIDS with pneumonia or pleuropneumonia, we found intra-alveolar hemorrhages with positive macrophage Perls' staining in 6 patients; diagnosis of bronchopulmonary Kaposi's sarcoma was documented pathologically by bronchial biopsy in 3, open lung biopsy in 2, and autopsy in 1. There were no false-positive results. Conversely, 1 patient with a suggestive endoscopic appearance had a...References1. OGNIBENESTEISMACHER FRA. Kaposi's sarcoma causing pulmonary infiltrate and respiratory failure in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;102:471-5. LinkGoogle Scholar2. ROZENBAUMCOULAUDSAIMOTKLATZMANNMAYAUDCARETTE WJADCM. Multiple opportunistic infection in a male homosexual in France. Lancet. 1982;1:572-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JEAN L. TOUBOUL, M.D.; CHARLES M. MAYAUD, M.D.; PIERRE FOURET, M.D.; GEORGES M. AKOUN, M.D.Affiliations: Hôpital Tenon 75020 Paris France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAIDS and the lung: update 1992. 2. Recent developments in the management of the pulmonary complications of HIV disease.Patología y citopatología pulmonar en el síndrome de inmunodeficiencia adquiridaA review of pulmonary cytopathology in the acquired immunodeficiency syndromeBilateral Chylothorax with Pulmonary Kaposi's SarcomaPulmonary Kaposi's sarcoma in patients with acquired immune deficiency syndrome: a clinicopathological study. 1 November 1985Volume 103, Issue 5Page: 808-808KeywordsAIDSBiopsyHemorrhageKaposi sarcomaLesionsLungsMacrophagesPleural effusionPneumoniaStaining ePublished: 1 December 2008 Issue Published: 1 November 1985 PDF downloadLoading ...