tbuckley/cabot-search huggingface dataset:
Medical Practices Committee's surveys of vacancies in general practice look at all vacancies
Authors: M. Leigh
Journal: BMJ (1996)

EDITOR,—In their study of factors influencing the response to advertisements for vacancies in general practice Robin Carlisle and Sue Johnstone used a questionnaire based on that used by the Medical Practices Committee in its study of 1994.1 Their references also include one to the committee's recruitment survey report of 1995.2

The committee's aim is to ensure that, when account is taken of the …
Dental Amalgam Restorations and Children’s Neuropsychological Function: The New England Children’s Amalgam Trial
Authors: David C. Bellinger, David Daniel, Felicia Trachtenberg, Mary Tavares, Sonja McKinlay
Journal: Environmental Health Perspectives (2006)

BackgroundA concern persists that children's exposure to mercury vapor from dental amalgams produces neurotoxicity.ObjectiveOur goal was to compare the neuropsychological function of children, without prior exposure to dental amalgam, whose caries were repaired using either dental amalgam or mercury-free composite materials.MethodsWe conducted a randomized controlled trial involving 534 6- to 10-year-old urban and rural children who were assessed yearly for 5 years using a battery of tests of intelligence, achievement, language, memory, learning, visual–spatial skills, verbal fluency, fine motor function, problem solving, attention, and executive function.ResultsAlthough the mean urinary mercury concentration was greater among children in the amalgam group than the composite group (0.9 vs. 0.6 μg/g creatinine), few significant differences were found between the test scores of children in the two groups. The differences found were inconsistent in direction. Analyses using two cumulative exposure indices—surface years of amalgam and urinary mercury concentration—produced similar results.ConclusionsExposure to elemental mercury in amalgam at the levels experienced by the children who participated in the trial did not result in significant effects on neuropsychological function within the 5-year follow-up period.
The Paradox of Technology: Learning to Share Control With the Patient-Reply
Authors: Carlos A. Reyes-Ortiz
Journal: JAMA (1997)

<h3>In Reply.</h3> —Mr Davidson describes the crowding out of human factors by technological concerns. We understand this phenomenon as the predictable result of an underlying clinical philosophy that gives highest priority to achieving and maintaining control. We have proposed an alternative clinical philosophy based instead on relation—a balance between control and receptivity—that keeps the lived experience of the patient in the foreground, and it also ameliorates some problems of overly aggressive treatment and physician satisfaction.<sup>1</sup> Dr Reyes-Ortiz points to the clinician's capacity for perception, moral reasoning, and relationship as the foundations of empathic communication. We enthusiastically agree. The descriptive model we proposed addresses only 1 aspect of perception: recognizing the presentation of emotion. Support groups to enhance self-awareness, video review of office visits to improve communication skills, and personal spiritual practice are but 3 of the many other types of activities that clinicians might pursue to enhance their capacity for empathy.
TETANY IN ACUTE SUPPURATIVE APPENDICITIS IN AN ADULT
Authors: B. Hughes
Journal: BMJ (1913)

TMDTrCALJOUUNqAL 879 which haemoglobin had been dded, a medium I use altogether for the isolation of the gonococcus.No gonococcus-like organisms grew on any of the media except the latter, and on this there developed a number of clharacteristic colonies, which on staining showed the usual characters of this organism.Subcultures of the pure growth mere made on the ascitic media, as well as on various others; only on the ascitic agar did any growth occur, and only a limited number of the colonies showed ability or desire to grow in subculture.Even those which did grow in subculture were very sensitive to their surroundings, and the one pure culture which I kept for stock, now in its sixty-fifth transfer, needs to be transferred every day or it will die.I have not been able to make it grow on any modification, even, of the original medium.
Doctors and nurses: doing it differently
Authors: J. Salvage
Journal: BMJ (2000)

<h3>Background</h3> The pangenotypic direct-acting antivirals glecaprevir (identified by AbbVie and Enanta) coformulated with pibrentasvir (G/P) are approved to treat chronic HCV genotype (GT) 1–6 infection. Eight-week G/P achieved high SVR12 rates in Phase 2 and 3 studies, but was not studied in patients with compensated cirrhosis. Based on the high SVR12 rates demonstrated in treatment-naive patients with HCV GT1–6 infection and compensated cirrhosis treated with 12-week G/P, this study evaluates the efficacy and safety of an 8-week G/P treatment duration in that population. <h3>Methods</h3> EXPEDITION-8 is an ongoing phase 3, non-randomized, single arm, open-label, multicenter study conducted in adults with chronic HCV GT1–6 infection with compensated cirrhosis who are HCV treatment-naive. A recently approved protocol amendment enabled the inclusion of HCV GT3-infected patients, who are not included in this analysis. G/P (300 mg/120 mg) is being dosed orally once-daily with food for 8 weeks. The primary efficacy endpoint is the SVR12 rate. Secondary endpoints are the on-treatment virologic failure and relapse rates. Adverse events and clinical laboratory abnormalities are being monitored in all patients. <h3>Results</h3> In total, 280 treatment-naive patients with compensated cirrhosis have enrolled and are included in the analysis. To date, 116 patients have completed the post-treatment week 12 visit; (figure 1) shows preliminary efficacy results for those with available post-treatment week 4 and/or 12 data. No virologic failures have occurred. Adverse events (AEs) have been mostly mild, with the most common (at least 5%) AEs being pruritus and fatigue (both 9%), headache (7%) and nausea (6%). No AEs have led to discontinuation of G/P; 5 serious AEs have occurred, none of which were deemed related to G/P. <h3>Conclusions</h3> In this ongoing study, G/P for 8 weeks in treatment-naive patients with HCV infection and compensated cirrhosis has been well-tolerated and achieved high rates of SVR, with no virologic failures to date. Updated efficacy and safety data will be presented at the meeting.
Book Review Law in Public Health Practice Second edition. Edited by Richard A. Goodman, Richard E. Hoffman, Wilfredo Lopez, Gene W. Matthews, Mark A. Rothstein, and Karen L. Foster. 570 pp. New York, Oxford University Press, 2007. $59.95. 978-0-19-530148-9
Authors: Ilise L. Feitshans
Journal: New England Journal of Medicine (2007)
Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia.
Authors: M I Block, M Berg, M J McNamara, J A Norton, D L Fraker, H R Alexander
Journal: The Journal of Experimental Medicine (1993)

D factor, also known as leukemia inhibitory factor, is a pleiotropic cytokine whose role during acute injury and inflammation is not known. Intraperitoneal administration of Escherichia coli endotoxin induced D factor gene expression in mice, and passive immunization against D factor protected them from the lethal effects of endotoxin and blocked endotoxin-induced increases in serum levels of interleukin 1 and 6. Peak levels of tumor necrosis factor and interferon gamma were not affected. These results indicate that D factor is an essential early mediator of the inflammatory cytokine response and therefore may be important in the pathogenesis of the many inflammatory conditions, such as sepsis, arthritis, allograft rejection, and cancer immunotherapy.
THE DEBILITY OF ADOLESCENCE.
Authors: LOUIS FAUGÈRES BISHOP
Journal: JAMA (1898)

It has always been a puzzle to me to know just when the specialist on diseases of children gave up his case to the specialist on older people, and just when the specialist on older people gave up his patients to the specialist on old age. This suggests the existence of transition periods. There might well be study devoted to the period during which the child is passing from childhood to maturity. Of course, the child grows steadily from birth to manhood, but there is a period during the latter part of this time to which the name of adolescence is given, a period during which the youth is subject to particular departures from health. During this period, when the active forces of early development have begun to wane and the solidification of maturity has not yet taken place, the organs are especially susceptible to damage from whatever causes may
Propranolol Therapy in Patients With Cardiac Disease
Authors: Stanford Wessler
Journal: JAMA (1968)

Dr. Sidney Jick, Associate Attending Physician, the Jewish Hospital of St. Louis, and Clinical Instructor in Medicine, Washington University School of Medicine: A 67-year-old business executive with a 20-year history of chronic atrial fibrillation was hospitalized in February 1967 because of recurrent palpitation during slight exertion. During the past 20 years, despite large doses of digitalis and other drugs including quinidine sulfate, the patient often experienced episodes of rapid heart action, particularly on very modest effort. In 1965, cardioversion was successfully performed with 400 watt-seconds, but normal sinus rhythm was maintained for only two days. Physical examination revealed an elderly white man in no distress. Pulse rate was 78 beats per minute and irregular; blood pressure was 130/95 mm Hg and respiration rate was 16 per minute. Findings from examination of the head, ears, eyes, nose, throat, abdomen, and extremities were unremarkable. The chest was clear to percussion and auscultation.
The significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
Authors: Li-Juan Zhang, Ji Xu, Peng Liu, Chong-Yang Ding, Jian-Yong Li, Hong-Xia Qiu, Su-Jiang Zhang
Journal: Journal of Hematology & Oncology (2012)

This study was aimed to investigate the significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis (sHLH) patients. A total of 18 patients received 18F-FDG PET/CT scan at initial diagnosis. All patients (18/18) had at least 3 organs involved, with increased FDG metabolism in different degrees. Fifteen cases (15/18) had definite underlying diseases, including infections (IAHLH), rheumatosis (RAHLH), or malignancy (MAHLH). The SUVmax of patients in MAHLH group was significantly higher than patients in IAHLH group or RAHLH group (P = 0.015, P = 0.045). Furthermore, the SUVmax of patients in IAHLH group was significantly higher than patients of RAHLH group (P = 0.043). Therefore, we concluded that 18F-FDG PET/CT may especially play important role in differential diagnosis of sHLH.
Treatment with gefitinib (ZD 1839) in a patient with advanced cutaneous squamous cell carcinoma
Authors: M. Baltaci, P. Fritsch, F. Weber, A. Tzankov, P. Sogner, A.M. Derler, R. Hopfl
Journal: British Journal of Dermatology (2005)

Journal Article Treatment with gefitinib (ZD 1839) in a patient with advanced cutaneous squamous cell carcinoma Get access M. Baltaci, M. Baltaci Clinical Department of Dermatology and Venereology, Institute of Pathology Search for other works by this author on: Oxford Academic Google Scholar P. Fritsch, P. Fritsch Clinical Department of Dermatology and Venereology, Institute of Pathology Search for other works by this author on: Oxford Academic Google Scholar F. Weber, F. Weber Clinical Department of Dermatology and Venereology, Institute of Pathology Search for other works by this author on: Oxford Academic Google Scholar A. Tzankov, A. Tzankov Clinical Department of Dermatology and Venereology, Institute of Pathology Search for other works by this author on: Oxford Academic Google Scholar P. Sögner, P. Sögner Clinical Department of Radiology II, Innsbruck Medical University, Anichstraße 35, A‐6020 Innsbruck, Austria E‐mail: mehmet.baltaci@uibk.ac.at Search for other works by this author on: Oxford Academic Google Scholar A.M. Derler, A.M. Derler Clinical Department of Dermatology and Venereology, Institute of Pathology Search for other works by this author on: Oxford Academic Google Scholar R. Höpfl R. Höpfl Clinical Department of Dermatology and Venereology, Institute of Pathology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 1, 1 July 2005, Pages 234–236, https://doi.org/10.1111/j.1365-2133.2005.06709.x Published: 01 July 2005
ALTERATION OF ALDOSTERONE RESPONSE TO SALT OVERLOAD THROUGH CHRONIC KIDNEY DISEASE IN PATIENTS WITH HYPERTENSION
Authors: Nagaharu Fukuma, Hiroshi Takahashi, Hiroko Hayashi, Kazuyo Kato, Yuko Kato, Kouichi Mabuchi, Yoshiko Miyatake, Yumiko Fukuma, Kyouichi Mizuno
Journal: Journal of the American College of Cardiology (2011)
High Suicide Risk Found for Patients With Head and Neck Cancer
Authors: John L. Zeller
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization
Authors: J Dierlamm, C Rosenberg, M Stul, S Pittaluga, I Wlodarska, L Michaux, M Dehaen, G Verhoef, J Thomas, W de Kelver, T Bakker-Schut, JJ Cassiman, AK Raap, C De Wolf-Peeters, H Van den Berghe, A Hagemeijer
Journal: Leukemia (1997)
Surgery of the Peripheral Nerve
Authors: Elof Eriksson
Journal: JAMA (1990)

The authors of this text are both plastic surgeons. Dr Dellon has studied sensory nerves extensively, sensibility testing and sensory reeducation in particular. Dr Mackinnon has had a long-term interest in nerve physiology as it relates to surgery on peripheral nerves and, particularly, grafting with autografts and allografts. Both authors are international authorities in their fields, and they also have a large experience with various peripheral nerve problems that are treated surgically. In order to be logical, comprehensive, and nonrepetitious, the authors have chosen to write this text themselves, and this appears to be a very good decision. The focus of this text is the surgery of peripheral nerve disorders, with which the authors have extensive, either clinical or research, experience. They have chosen a strict organization of the contents that starts with a macroscopic, microscopic, and ultrastructural description of the anatomy of peripheral nerves. The physiology of peripheral nerves
ENTERICOID FEVER—FEBRIS ENTERICOIDES
Authors: DAVID RIESMAN
Journal: JAMA (1913)

During the last few years I have seen a number of cases of continued fever that resembled typhoid fever but did not give the usual laboratory tests nor did they present all of the characteristic clinical features of that disease. In their symptomatology they did not, however, depart from the text-book description more than many well authenticated cases of typhoid fever. I am sure that every physician in active practice sees cases of fever that impress him in the beginning as typhoid, and if he commits himself to this diagnosis he is often much embarrassed to find that the duration is too short for it to be typhoid fever or that the case does not give the laboratory reactions of that disease. I am, of course, not referring to certain widely different infections that may assume a typhoid type, such as ulcerative endocarditis, miliary and cascous tuberculosis, meningitis, etc.  One of these typhoid-like infections has already been established as a clinical entity, namely
NEMO is a key component of NF-κB– and IRF-3–dependent TLR3-mediated immunity to herpes simplex virus
Authors: Magali Audry, Michael Ciancanelli, Kun Yang, Aurelie Cobat, Huey-Hsuan Chang, Vanessa Sancho-Shimizu, Lazaro Lorenzo, Tim Niehues, Janine Reichenbach, Xiao-Xia Li, Alain Israel, Laurent Abel, Jean-Laurent Casanova, Shen-Ying Zhang, Emmanuelle Jouanguy, Anne Puel
Journal: Journal of Allergy and Clinical Immunology (2011)
Weekly Urticaria Activity Score (UAS7) and Dermatology Life Quality Index (DLQI) in Validation of Chronic Spontaneous/Idiopathic Urticaria (CSU/CIU) Health States
Authors: Sam Khalil, Doreen McBride, Ana Gimenez-Arnau, Clive Grattan, Maria-Magdalena Balp, Donald E. Stull
Journal: Journal of Allergy and Clinical Immunology (2015)
Hypokalaemia and xipamide
Authors: A J M Boulton, C A Hardisty
Journal: BMJ (1982)

Hypokalaemia and xipamide SIR,-I read the paper entitled "Ventricular fibrillation induced by xipamide" (13 February, p 494) with great interest.We published a paper from this department in 1981,1 in which we drew attention to the fact that xipamide, although a very effective antihypertensive agent, caused profound re- ductions in the serum potassium concentra- tions, which were potentially dangerous, and recommended that it should not be used for this purpose unless adequate potassium supplements were given at the same time.'It is not clear to me, however, why the authors have included indapamide in their indictment of xipamide since their case report refers to a patient who was simply taking the latter drug and not the former.There are some chemical similarities between the two drugs, in that both are derivatives of chlorosulphonamide (xipamide is a salicylic acid derivative and indapamide an indoline derivative) but there would appear to be substantial pharma- cological differences between the two.Xipamide is undoubtedly a potent diuretic,2
Integrated Psychotherapy in the Project of the Treatment of Psychoses
Authors: Gabriella Ba, Italo Carta
Journal: Psychotherapy and Psychosomatics (1989)

We present a model of integrated psychotherapy of schizophrenia. When we do an integrated therapy with a patient, attention must always be directed to the calibration of the interventions which constitute the therapeutic compound. This kind of calibration has to be done by a therapist with an integrative function. Experience and competence are necessary conditions, but not sufficient ones for carrying out such a function; the therapist must have also the authority which is due not only to his hierarchic role, but which has to be empathically recognized by the other therapists and the patient. The theoretical reflection has been possible only by starting from a clinical experience (the case of a young woman who in the light of the nosographical categories was considered an 'impossible patient') which allowed us to translate the clinical language into a conceptual form.
OP0199 No Increased Risk of Congenital Malformations after Preconception Paternal Exposure to Dmards: Table 1
Authors: M. Wallenius, E. Lie, H.S. Koksvik, K. Å. Salvesen, A.K. Daltveit, J. Skomsvoll, M. Østensen
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The risk of congenital malformations in offspring of men with inflammatory joint diseases (IJD) treated with disease modifying antirheumatic drugs (DMARDs) before conception is largely unknown. <h3>Objectives</h3> To study the occurrence of severe malformations in offspring of male patients with IJD exposed to DMARDs within 3 months before conception compared with references from the general population. <h3>Methods</h3> The national identification numbers of both the mother and the father of the newborn are registered in the Medical Birth Registry of Norway (MBRN). Linkage of data from a longitudinal observational study of IJD patients (NOR-DMARD) and the MBRN enabled to study potential associations of severe congenital malformation in offspring after paternal exposure to DMARDs within 3 months of conception compared to deliveries from the general population. Births in the period 2000-2011 were analyzed. Potential associations were assessed by logistic regression analysis with adjustments for maternal and paternal age at delivery and for year of birth and presented as adjusted odds ratios with corresponding 95% confidence intervals. The birth defects included severe malformations in any organ system. The definition of severe malformations in MBRN is in accordance with the European Registration of Congenital Anomalies (EUROCAT) (1). All severe congenital anomalies were grouped together as one entity. <h3>Results</h3> Among 3866 male IJD patients there were 110 paternal pre-conception DMARD exposed births. The distribution of pre-conception synthetic and biological DMARDs among the 110 births were as follows: TNF-α inhibitors as monotherapy 33%, TNF-α inhibitors in combination with methotrexate (MTX) 19%, MTX monotherapy or in combinations with other synthetic DMARDs 25%, sulfasalazine 15%, other medications (leflunomide, azathioprine, hydroxychloroquine) 7%. The dose of MTX ranged between 12.5-20 mg weekly. <h3>Conclusions</h3> Preconception paternal exposure to DMARDs was not associated with increase in adverse outcomes of pregnancy. <h3>References</h3> European Surveillance of Congenital Anomalies, EUROCAT Guide 1.3, chapter 3.3: Coding of EUROCAT subgroups of congenital anomalies. Available from: www.eurocat-network.eu/ <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2742
287Human induced pluripotent stem cells for tissue-engineered cardiac repair
Authors: K Breckwoldt, F Weinberger, S Pecha, B Geertz, J Starbatty, A Hansen, T Eschenhagen
Journal: Cardiovascular Research (2014)

Myocardial infarction causes unrecoverable loss of cardiomyocytes. Engineered heart tissue (EHT) is an in vitro model of three-dimensional, force generating cardiomyocyte network with morphological and functional similarity to native heart tissue. In this study we transplanted EHTs from human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CM) on cryo-injured guinea pig hearts and investigated whether hiPSC-CM-EHTs support left ventricular function.
Pregnancy Loss: Medical Therapeutics and Practical Considerations
Authors: Alex S. Tulsky
Journal: JAMA (1987)

This timely book addresses a topic that many of us would prefer to ignore and, indeed, have ignored for too many years, for reasons that are complex and even unpleasant to contemplate. In brief, it is a presentation of the psychosocioeconomic upheaval that may, and often does, accompany the loss of a pregnancy, whether by miscarriage, immaturity, prematurity, eccyesis, or stillbirth. Furthermore, it offers sound advice on recognizing this upheaval and dealing with it in the best long-range interest of the woman and her family, as well as the physician and other health care attendants. I well remember, many years ago, from the stratospheric vantage of an obstetrics house officer in a large Eastern hospital, how odd I thought it was that a certain group of Orthodox Jews, who used that hospital for their medical needs, insisted on giving a ritual burial to what I saw simply as the first-trimester