tbuckley/cabot-search huggingface dataset:
Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes
Authors: Yasuteru Urano, Daisuke Asanuma, Yukihiro Hama, Yoshinori Koyama, Tristan Barrett, Mako Kamiya, Tetsuo Nagano, Toshiaki Watanabe, Akira Hasegawa, Peter L Choyke, Hisataka Kobayashi
Journal: Nature Medicine (2008)
Muscle Histology in Rheumatic and Control Cases: A Study of One Hundred and Nineteen Biopsy Specimens
Authors: M. H. L. Desmarais, H. J. Gibson, G. D. Kersley
Journal: Annals of the Rheumatic Diseases (1948)

were Masson's trichrome, Foot's reticulin stain, and Unna-Pappenheim stain for plasma cells.In order to obtain an unbiased assessment of the experimental findings the cases were carefully examined clinically and grouped according to a tentative classi- fication.The biopsy material was reported on by the pathologist without knowledge of the clinical findings.The pathological and clinical data were later correlated.132
Remarkably similar response to gold therapy in HLA identical sibs with rheumatoid arthritis.
Authors: L.B van de Putte, F Speerstra, P.L van Riel, A.M Boerbooms, P.J van't Pad Bosch, P Reekers
Journal: Annals of the Rheumatic Diseases (1986)

Two pairs of sibs with definite rheumatoid arthritis responded in a remarkably similar way to parenteral gold therapy, in terms of both toxicity and efficacy. Both pairs proved to be HLA identical. One of the pairs possessed the HLA antigens B8 and DR3, which have been associated with both drug toxicity and excellent clinical response. The other pair did not possess either of these antigens, suggesting that the reaction to gold therapy in patients with rheumatoid arthritis may be determined by other HLA or genetic factors coded for by chromosome 6, or both.
Case of Empyema: In Which Nineteen Pints and a Half of Pus Were Removed by an Opening Made into the Cavity of the Chest, with Remarks
Authors: J. Tucker
Journal: BMJ (1849)

IL-23 activates the synthesis and production of leukotriene B<sub>4</sub> (LTB<sub>4</sub>) in myeloid cells, which modulate inflammatory arthritis. In this study we investigated the role of LTB<sub>4</sub> and its receptor LTB<sub>4</sub>R1 (BLT1) in synovial inflammation and osteoclast differentiation. Specifically, we used IL-23 in vivo gene transfer to induce arthritis in mice and showed that elevated serum LTB<sub>4</sub> and synovial expression of 5-lipoxygenase correlated with increased disease severity by histological evaluation and paw swelling compared with GFP gene transfer controls. To further investigate the effect of the LTB<sub>4</sub> pathway in bone loss, we performed osteoclast differentiation assays by stimulating with M-CSF and receptor activator of NF-κB ligand bone marrow cells derived from BLT1<sup>+/+</sup> and/or BLT1<sup>−/−</sup> mice and used quantitative PCR for gene expression analysis in terminally differentiated osteoclasts. Deficiency in BLT1 resulted in the upregulation of osteoclast-related genes and an increase in the formation of giant, multinucleated TRAP<sup>+</sup> cells capable of F-actin ring formation. Additionally, BLT1 deficiency showed an increase of phosphorylated NF-κB and phosphorylated IκB levels in osteoclasts. We also performed real-time calcium imaging to study the effect of BLT1 deficiency in receptor activator of NF-κ-B ligand–induced activation of intracellular calcium flux in vitro. Our data show that LTB<sub>4</sub> and its receptor BLT1 exacerbate synovial inflammation in vivo and bone resorption in vitro, suggesting that LTB<sub>4</sub> and BLT1 could be effectively targeted for the treatment of musculoskeletal diseases.
Beyond Diagnosis
Authors: Ian Renwick McWhinney
Journal: New England Journal of Medicine (1972)

Abstract Failure to integrate behavioral science with clinical medicine is due to a lack of a schema for classifying patient behavior. A useful system for classifying patient behavior at the point of contact with the physician has five categories: attendance with symptoms or problems that have reached the limit of tolerance; attendance with symptoms that provoke action not because they cause distress but because of their implications; problems of living presenting as symptoms; attendance for administrative reasons; and attendance for reasons other than illness. To fill a similar need for a taxonomy of social factors in illness, another schema for classifying interactions between patients and their environment has seven categories: loss, conflict, change, maladjustment, stress, isolation and failure. These systems, used in parallel with traditional clinical diagnosis, should provide a useful tool for the integration of behavioral science with clinical medicine.
Are general practitioners equipped to manage acute severe asthma?
Authors: S. A Evans, J. Stoner, C. Hardy
Journal: BMJ (1994)

The British Thoracic Society issued guidelines on the management of asthma in response to "unacceptably high" morbidity and mortality associated with asthma.' 2 Information on treatment of acute asthma in the community is sparse.A recent study provided information from selected general practitioners, 47% of whom were members of the General Practitioners in Asthma Group; only 6% of non-members responded.3Nebulised bronchodilators and systemic steroids were found to be underused.To gain a more representative picture we have used equipment and drugs carried by general practitioners as a surrogate measure of assess- ment and treatment of asthma in the community.through pear spacer in acute severe asthma.
Acquired Chromosomal Anomalies Induced in Mice by a Known Teratogen
Authors: Theodore H. Ingalls, Estelle F. Ingenito, Francis J. Curley
Journal: JAMA (1964)

REPORTS of the association of chromosomal anomalies with congenital malformations encountered in clinical practice and in stillborn babies at autopsy have become increasingly frequent in recent years. At the same time, natural and experimental epidemiologic evidence more and more firmly establishes the environmental causation of many malformations, notably after rubella and thalidomide in the first trimester of human pregnancy, Veratrum consumption and vitamin deficiencies in sheep, and antimetabolites and oxygen deficiency in rodents. Since these facts need to be either reconciled or explained, investigations to test whether chromosomal anomalies could be introduced by the same agent known to be capable of causing a gross congenital defect were undertaken at the Henry Phipps Institute.<sup>1</sup>Cleft palate in our own colony of mice was selected for study because the pathogenesis of this defect in this colony had long been the subject of experimentation by Ingalls, Prindle, Curley, and Watanabe using other
Minister counters royal college claims about NHS allergy services
Authors: Bruno Rushforth
Journal: BMJ (2004)

The NHS is “coping” with allergy control, the health minister Dr Stephen Ladyman told a recent meeting of the health select committee, despite evidence to the same committee from the Royal College of Physicians suggesting that services were “totally inadequate.”

Dr Ladyman, under-secretary of state at the Department of Health, defended the current approach to the provision of allergy services, saying: “On the evidence we have the service is coping.”

But he acknowledged the constant drive to improve services: “The NHS needs to keep pace with both the change in medical knowledge and change in prevalence [of …
Auriculoventricular Nodal Rhythm*†
Authors: CARL V. VISCHER
Journal: Annals of Internal Medicine (1932)

Article1 February 1932Auriculoventricular Nodal RhythmWith Report of CasesCARL V. VISCHER, M.D., F.A.C.P., LOWELL L. LANE, A.B., M.D.CARL V. VISCHER, M.D., F.A.C.P.Search for more papers by this author, LOWELL L. LANE, A.B., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-8-1010 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExperiment has demonstrated that not only the sinus node but the A-V node, the auriculoventricular bundle of His and the bundle branches, with their arborizations have the capacity for impulse production. This fact was established by the Stannius' ligatures. If a ligature is tied around the sinus of a frog's heart, or placed below the level at which the cardiac rhythm is generated, the heart ceases to beat temporarily below the level of this ligature, but after a brief standstill takes up a regular rhythm of its own. This new rhythm is generated in a lower center and is slower...References LEWIS T: The mechanism and graphic registration of the heart beat, 1921, Paul B. Hoeber, New York. Google Scholar LEWIS T: Clinical electrocardiography, 1928, Shaw and Sons, Ltd., London. Google Scholar EASTBAIN CFCW: Recent advances in cardiology, 1931, P. Blakiston's and Sons, Philadelphia. Google Scholar PARSONNETHYMAN AEAS: Applied electrocardiography, 1929, Macmillan Company, New York. Google Scholar WHITE PD: Heart disease, 1931, Macmillan Company, New York. Google Scholar GÉRAUDEL #: The mechanism of the heart and its anomalies, 1930, Williams and Wilkins Company, Baltimore. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa.*From the Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia, Pa.†Received for publication, June 1, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1932Volume 5, Issue 8Page: 1010-1016KeywordsHeartHospital medicineLigation assay Issue Published: 1 February 1932 PDF DownloadLoading ...
Multifocal Paragangliomas Depicted by I-123 Metaiodobenzylguanidine
Authors: HANS JACOBSSON, JOHAN SVARTBERG, GÖRAN WALLIN, LARS GRIMELIUS, STIG A. LARSSON
Journal: Clinical Nuclear Medicine (1998)

A 23-year-old man was hospitalized because of hypertension, heart palpitations, headache, and sweating. Clinical investigation revealed a highly increased urinary excretion of norepinephrine. Radionuclide imaging with 1-123 metaiodobenzylguanidine showed a series of hot spots at the lower portion of the left sympathetic chain. The radiotracer bears a structural resemblance to norepinephrine, It accumulates in neurosecretory storage granules of chromaffin cells and is used to localize ofneural crest tumors. At surgery, four separate tumor masses were removed. The diagnosis was multifocal paragangliomas. One year after surgery, the patient is clinically well and the urinary catecholamines are normal.
[88] VIRAL KINETICS DURING 14-DAY TREATMENT WITH DEBIO-025 DEMONSTRATE EFFICIENT BLOCKING OF VIRAL REPLICATION IN DIFFERENT HCV GENOTYPES WITHOUT SIGNS OF EMERGING VIRAL RESISTANCE
Authors: E. Herrmann, R. Flisiak, A. Horban, R. Crabbe, H. Porchet, V. Nicolas, P. Scalfaro, S. Zeuzem
Journal: Journal of Hepatology (2007)
Plasma Levels of Immunoreactive Corticotrophin in Patients with Cushing's Syndrome
Authors: G. M. Besser, J. Landon
Journal: BMJ (1968)

Plasma levels of immunoreactive corticotrophin (A.C.T.H.) have been determined in 56 patients with Cushing9s syndrome by means of a homologous radioimmunoassay. In untreated Cushing9s disease (bilateral adrenal hyperplasia due to excessive A.C.T.H. secretion from the pituitary) plasma values ranged from 40 to 200 μμg./ml., between 8 and 10 a.m., compared with a range in normal subjects of 12 to 60 μμg./ml. Considerably raised levels, often above 2,000 μμg./ml., were found in patients with Cushing9s disease after bilateral adrenalectomy. A.C.T.H. concentrations were usually higher in patients with bilateral adrenal hyperplasia associated with ectopic A.C.T.H. production than in patients with untreated Cushing9s disease; whereas plasma A.C.T.H. was undetectable in the presence of an adrenocortical tumour. All patients with Cushing9s syndrome failed to show the normal circadian rhythm of circulating A.C.T.H. levels.
Abstract SY16-03: Dose matters and angiogenesis
Authors: Kairbaan M. Hodivala-Dilke
Journal: Cancer Research (2011)

Abstract Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays a fundamental role in integrin and growth factor mediated signaling and is an important player in cell migration and proliferation, processes vital for angiogenesis. However, the role of FAK in adult pathological angiogenesis is unknown. We have generated endothelial-specific tamoxifen-inducible FAK knockout mice by crossing FAK-floxed (FAKfl/fl) mice with the Pdgfb-iCreER mice. Tamoxifen-treatment of Pdgfb-iCreER;FAKfl/fl mice results in FAK deletion in adult endothelial cells (EC) without any adverse effects. Importantly however, endothelial FAK-deletion in adult mice inhibited tumor growth and reduced tumor angiogenesis. Furthermore, in in vivo angiogenic assays FAK-deletion impairs vascular endothelial growth factor (VEGF)-induced neovascularization. In addition, in vitro deletion of FAK in ECs resulted in reduced VEGF-stimulated AKT phosphorylation, and correlating reduced cellular proliferation and increased cell death. Our data suggest that FAK is required for adult pathological angiogenesis and validates FAK as a possible target for antiangiogenic therapies. In a follow up study we are testing the effects of reduced, as apposed to null, levels of FAK on tumor angiogenesis and will be reporting on that at the meeting. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr SY16-03. doi:10.1158/1538-7445.AM2011-SY16-03
MRSA May Move From Livestock to Humans
Authors: Bridget Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effect of ketanserin on healing of fresh surgical wounds
Authors: C.M. LAWRENCE, J.N.S. MATTHEWS, N.H. COX
Journal: British Journal of Dermatology (2006)

This study was designed to investigate the effect of topical ketanserin, a selective S2‐serotonin antagonist, on wound healing and contraction in surgical wounds allowed to heal by second intention. Thirty‐five patients applied placebo or 2% ketanserin gel, double‐blind, to head and neck wounds resulting from skin tumour excision, and allowed to heal by second intention. Healing rate was assessed from the change in the square root of wound area, and in 11 patients wound contraction was assessed by the change in the area delineated by wound margin tattoo marks. There were no significant differences in any of the measurements made between the ketanserin‐ and placebo gel‐treated patients. Wound healing was significantly faster in large wounds. Wound contraction was greatest in the early stages of healing, and accounted for 53% of healing. We conclude that, on normally vascularized skin, ketanserin gel has no significant effect on wound healing rate.
Anticipating the Effects of Accountable Care Organizations for Inpatient Surgery
Authors: David C. Miller, Zaojun Ye, Cathryn Gust, John D. Birkmeyer
Journal: JAMA Surgery (2013)

<h3>Importance</h3>Much of the enthusiasm for accountable care organizations is fueled by evidence that integrated delivery systems (IDSs) perform better on measures of quality and cost in the ambulatory care setting; however, the benefits of this model are less clear for complex hospital-based care.<h3>Objective</h3>To assess whether existing IDSs are associated with improved quality and lower costs for episodes of inpatient surgery.<h3>Design, Setting, and Patients</h3>We used national Medicare data (January 1, 2005, through November 30, 2007) to compare the quality and cost of inpatient surgery among patients undergoing coronary artery bypass grafting, hip replacement, back surgery, or colectomy in IDS-affiliated hospitals compared with those treated in a matched group of non–IDS-affiliated centers.<h3>Main Outcome Measures</h3>Operative mortality, postoperative complications, readmissions, and total and component surgical episode costs.<h3>Results</h3>Patients treated in IDS hospitals differed according to several characteristics, including race, admission acuity, and comorbidity. For each of the 4 procedures, adjusted rates for operative mortality, complications, and readmissions were similar for patients treated in IDS-affiliated compared with non–IDS-affiliated hospitals, with the exception that those treated in IDS-affiliated hospitals had fewer readmissions after colectomy (12.6% vs 13.5%, P = .03). Adjusted total episode payments for hip replacement were 4% lower in IDS-affiliated hospitals (P &lt; .001), with this difference explained mainly by lower expenditures for postdischarge care. Episode payments differed by 1% or less for the remaining procedures.<h3>Conclusions</h3>The benefits of the IDSs observed for ambulatory care may not extend to inpatient surgery. Thus, improvements in the quality and cost-efficiency of hospital-based care may require adjuncts to current ACO programs.
Chinese would resist having larger families if one child policy was relaxed
Authors: I. Torjesen
Journal: BMJ (2010)

<h3>Abstract</h3> Chromosomes have an intrinsic tendency to segregate into compartments, forming long-distance contacts between loci of similar chromatin states. However, how genome compartmentalization is regulated remains elusive. We analyzed two closely and developmentally related pluripotent cell types: ground-state ESCs that have an open and active chromatin and developmentally advanced ESCs that display a more closed and repressed state. We show that these two ESC types differ in their regulation of genome organization due to their differential dependency on TIP5, a component of the chromatin remodeling complex NoRC. We show that TIP5 interacts on ESC chromatin with SNF2H, DNA topoisomerase 2A (TOP2A) and cohesin. TIP5 associates with sub-domains within the active A compartment that strongly intersect through long-range contacts in ESCs. We found that only ground-state chromatin requires TIP5 to limit the invasion of active domains into repressive compartments. Depletion of TIP5 increased chromatin accessibility particularly at B compartments and decreased their repressive features. Furthermore, TIP5 acts as a barrier for the repressive H3K27me3 spreading, a process that also requires TOP2A activity. Finally, ground-state ESCs require TIP5 for growth, differentiation capacity, and correct expression of developmental genes. Our results revealed the propensity of open and active chromatin domains to invade repressive domains, an action counteracted by chromatin remodeling and the relief of chromatin torsional stress. This effort in controlling open/active chromatin domains is required to establish active and repressed genome partitioning and preserves cell function and identity.
Meta-Analysis of the Effect of Insulin Lispro on Severe Hypoglycemia in Patients With Type 1 Diabetes
Authors: Rocco L Brunelle, Julie Llewelyn, James H Anderson, Edwin A M Gale, Veikko A Koivisto
Journal: Diabetes Care (1998)

OBJECTIVE A precise time-action profile of insulin lispro (Humalog) at mealtime may reduce the incidence of severe hypoglycemia. Because it is a rare complication, we performed a cumulative meta-analysis to compare the frequency of severe hypoglycemia during insulin lispro and human regular insulin therapy in type 1 diabetic patients. RESEARCH DESIGN AND METHODS The analysis included eight large multicenter clinical trials, three with parallel and five with crossover designs. The studies included 2,576 type 1 diabetic patients in total, with 2,327 receiving insulin lispro and 2,339 receiving regular human insulin, representing &amp;gt;1,400 patient-years of insulin therapy. Severe hypoglycemia was defined as coma or requiring glucagon or intravenous glucose. The patients received either NPH or ultralente as their basal insulin and insulin lispro or regular human insulin before each meal. RESULTS Seventy-two patients (3.1%) had a total of 102 severe hypoglycemic episodes during insulin lispro therapy, compared with 102 patients (4.4%) with a total of 131 episodes during regular human insulin therapy (P = 0.024). CONCLUSIONS The results of this meta-analysis demonstrate that in type 1 diabetic patients, the frequency of severe hypoglycemia can be reduced by taking insulin lispro as compared with regular human insulin therapy.
Two unusual organisms, Aspergillus terreus and Metschnikowia pulcherrima, associated with the lung disease of ankylosing spondylitis
Authors: W. P. U. Kennedy, L. J. R. Milne, W. Blyth, G. K. Crompton
Journal: Thorax (1972)

Two male patients with ankylosing spondylitis and upper lobe fibrosis and cavitation are described. A pneumonic disease in one was associated with mycological and serological evidence of infection with <i>Aspergillus terreus</i> but no other aspergillus species. A large pulmonary mycetoma developed in the second patient and among a number of other fungal isolates was found the yeast <i>Metschnikowia pulcherrima.</i> The association of ankylosing spondylitis with bronchopulmonary aspergillosis is considered; <i>A. terreus</i> is described for the first time as a human pulmonary pathogen, and the possible pathogenicity of <i>M. pulcherrima</i> in the debilitated human subject is discussed.