Nephrogenic Fibrosing Dermopathy and High-Dose Erythropoietin Therapy
Authors: Sundararaman Swaminathan, Iftikhar Ahmed, James T. McCarthy, Robert C. Albright, Mark R. Pittelkow, Noel M. Caplice, Matthew D. Griffin, Nelson Leung
Journal: Annals of Internal Medicine (2006)

Letters1 August 2006Nephrogenic Fibrosing Dermopathy and High-Dose Erythropoietin TherapySundararaman Swaminathan, MBBS, Iftikhar Ahmed, MD, James T. McCarthy, MD, Robert C. Albright, DO, Mark R. Pittelkow, MD, Noel M. Caplice, MD, PhD, Matthew D. Griffin, MB BCh, and Nelson Leung, MDSundararaman Swaminathan, MBBSFrom Mayo Clinic College of Medicine, Rochester, MN 55905., Iftikhar Ahmed, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905., James T. McCarthy, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905., Robert C. Albright, DOFrom Mayo Clinic College of Medicine, Rochester, MN 55905., Mark R. Pittelkow, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905., Noel M. Caplice, MD, PhDFrom Mayo Clinic College of Medicine, Rochester, MN 55905., Matthew D. Griffin, MB BChFrom Mayo Clinic College of Medicine, Rochester, MN 55905., and Nelson Leung, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-3-200608010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Nephrogenic fibrosing dermopathy is a newly described cutaneous disorder characterized by mucin deposition and dermal infiltration of CD34+ spindle cells in patients with renal insufficiency (1). No etiologic factor besides kidney disease has been linked to this disorder, although CD34 is a marker of hematopoietic progenitor cells. Erythropoietin is the principal therapy for anemia in both dialysis and predialysis patients. Its use dramatically increased after the publication of the Dialysis Outcomes Quality Initiative guidelines for anemia management in 1997 (2). Of interest, this is the same year that the first case of nephrogenic fibrosing dermopathy was reported (3).Objective: ...References1. Cowper SE. Nephrogenic fibrosing dermopathy: the first 6 years. Curr Opin Rheumatol. 2003;15:785-90. [PMID: 14569211] CrossrefMedlineGoogle Scholar2. NKF-DOQI clinical practice guidelines for the treatment of anemia of chronic renal failure. National Kidney Foundation-Dialysis Outcomes Quality Initiative. Am J Kidney Dis. 1997;30:S192-240. [PMID: 9339151] MedlineGoogle Scholar3. Cowper SE, Robin HS, Steinberg SM, Su LD, Gupta S, LeBoit PE. Scleromyxoedema-like cutaneous diseases in renal-dialysis patients [Letter]. Lancet. 2000;356:1000-1. [PMID: 11041404] CrossrefMedlineGoogle Scholar4. LeBoit PE. What nephrogenic fibrosing dermopathy might be [Editorial]. Arch Dermatol. 2003;139:928-30. [PMID: 12873893] CrossrefMedlineGoogle Scholar5. Macdougall IC. Antibody-mediated pure red cell aplasia (PRCA): epidemiology, immunogenicity and risks. Nephrol Dial Transplant. 2005; 20 Suppl 4 iv9-15. [PMID: 15827058] CrossrefMedlineGoogle Scholar6. Drueke T. Hyporesponsiveness to recombinant human erythropoietin. Nephrol Dial Transplant. 2001; 16 Suppl 7 25-8. [PMID: 11590253] CrossrefMedlineGoogle Scholar7. Haroon ZA, Amin K, Jiang X, Arcasoy MO. A novel role for erythropoietin during fibrin-induced wound-healing response. Am J Pathol. 2003;163:993-1000. [PMID: 12937140] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Mayo Clinic College of Medicine, Rochester, MN 55905.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoErythropoietin, Gadolinium, and Nephrogenic Fibrosing Dermopathy Richard N. Hellman Erythropoietin, Gadolinium, and Nephrogenic Fibrosing Dermopathy Nelson Leung , Sundararaman Swaminathan , Iftikhar Ahmed , James T. McCarthy , Robert C. Albright , Mark R. Pittelkow , Noel M. Caplice , and Matthew D. Griffin Metrics Cited byNephrogenic Systemic Fibrosis as a Complication after Gadolinium-Containing Contrast Agents: A Rapid ReviewFibrotic Signaling Pathways of Skin Fibroblasts in Nephrogenic Systemic FibrosisToxicité rénale des produits de contraste non iodésNephrogenic Systemic FibrosisMagnetic Resonance Imaging for Interventions and SurgeryThe role of gadolinium chelates in the mechanism of nephrogenic systemic fibrosis: A critical updateMRI for Interventions and SurgeryGadolinium Contrast Agent-Induced CD163+ Ferroportin+ Osteogenic Cells in Nephrogenic Systemic FibrosisEvaluation of imatinib mesylate as a possible treatment for nephrogenic systemic fibrosis in a rat modelSafety of Older Generations of Gadolinium in Mild-to-Moderate Renal FailureCutaneous Manifestations of Renal DiseaseInsuffisance rénale chronique et dialyseToxic MetalsUnderstanding Nephrogenic Systemic FibrosisNephrogenic systemic fibrosis is found only among gadolinium‐exposed patients with renal 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Hellman, MDCurrent awareness: Pharmacoepidemiology and drug safetyGadolinium is detectable within the tissue of patients with nephrogenic systemic fibrosis 1 August 2006Volume 145, Issue 3Page: 234-235KeywordsAttentionBody weightCellsErythropoietinHematopoietic stem cellsHemoglobinMedical dialysisParathyroid hormoneResearch laboratoriesSerum ferritin levels ePublished: 1 August 2006 Issue Published: 1 August 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...