tbuckley/cabot-search huggingface dataset:
(45) Cutis verticis gyrata
Authors: S. Walton, E.H. Wyatt
Journal: British Journal of Dermatology (1987)

Journal Article (45) Cutis verticis gyrata Get access S. Walton, S. Walton Hull Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar E.H. Wyatt E.H. Wyatt Hull Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 98–99, https://doi.org/10.1111/j.1365-2133.1987.tb12085.x Published: 01 June 1987
Activation and desensitization of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. I. Characteristics of the secretory response.
Authors: P M Henson
Journal: The Journal of Experimental Medicine (1976)

The secretion of vasoactive amines from rabbit platelets induced by the platelet-activating factor (PAF) derived from IgE-sensitized rabbit basophils, was examined. The secretion required calcium has previously been shown to be noncytotoxic and was optimal in both rate and extent at 37 degrees C and pH 7.2. Different temperature-sensitive steps were rate limiting for secretion above or below 20 degrees C. The rate of secretion was dependent upon the concentration of PAF and also of platelets. Maximal rates were observed with relatively low concentrations of platelets (2.5 X 10(8)/ml), sharply contrasting with other platelet stimuli such as C3 or thrombin. The extent of secretion was dependent upon PAF concentration until a maximum of 50 or 60% of the serotonin was released and then declined with increasing amounts of PAF. This was interpreted to result from the platelets becoming desensitized to the PAF, a process that shuts off the secretion. Such a desensitization was demonstrated and was shown to be stimulus specific, i.e., other stimuli could still induce secretion from PAF-desensitized platelets. PAF extracted with ethanol from the albumin to which it is usually bound during preparation, exhibited similar characteristics, except that secretion of up to 90% of the serotonin was induced. The extracted PAF thus seemed less able to induce the desensitization. Its use did provide important evidence that populations of rabbit platelets are relatively homogenous in their ability to respond to PAF.
Breakdancer??s Pulmonary Embolism
Authors: SERAFIN TIU, INDRANI SRINIVASAN, HOWARD J. BANNER, ELISSA LIPCON KRAMER, NANCY B. GENIESER, JOSEPH J. SANGER
Journal: Clinical Nuclear Medicine (1986)

A case of pulmonary embolism caused by breakdancing is reported. There was no clinical suspicion of pulmonary embolism.
Off-Label Use of Drug-Eluting Stents
Authors: Ravi K. Bobba, Madhavi Bollu, Edward L. Arsura
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increase of intestinal carbon monoxide and hepatic nitric oxide in rats with prehepatic portal hypertension
Authors: M. Duran, M.A. Aller, M.D. Palma, E. Vara, M.P. Nava, C. Garcia, J. Arias-Diaz, J.L. Balibrea, J. Arias
Journal: Journal of Hepatology (2002)
Hepatocellular carcinoma: Recent progress
Authors: Kunio Okuda
Journal: Hepatology (1992)

HCC is not a major killer among malignant diseases in Western countries, and until recently few Western hepatologists were interested in this cancer.After the demonstration of an etiologic role for HBV infection in hepatocarcinogenesis, interest surged even in lowincidence countries, particularly among molecular biologists and oncologists.A large body of literature now exists dealing with molecular mechanism in HBVrelated human HCC and hepadnavirus-induced HCC in animals.The recent identification and cloning of hepatitis C virus (HCV) has focused interest on chronic C hepatitis which, under the name of non-A, non-B (NANB) hepatitis, had for some time been suspected as another etiological factor for HCC in certain areas of the world.It did not take long before well-documented evidence linked HCV to HCC.Imaging diagnosis of small-mass lesions in the liver has progressed remarkably in recent years, as emphasized in a previous review in this JOURNAL (1).In countries where detection and resection of small HCCs in cirrhotic livers are common practice, pathologists are discussing how to differentiate large, benign, hyperplastic nodules; adenomatous hyperplastic nodules with potential to transform; and early HCC lesions histopathologically.Radiologists are attempting to make similar diagnostic distinction by imaging alone with limited success.This review attempts to update the recent progress made in the basic study of HCC. EPIDEMIOLOGY AND ETIOLOGYAccording to Muiioz and Bosch (2), no clear indication of a change has appeared in the incidence rate of HCC in developed Western countries in the past 20 yr or so as far as cancer registry data are concerned.However, in Japan, incidence of HCC began to increase about 20 yr ago; the increase was accounted for by non-HBV-related cases, and an etiologic role of chronic NANB hepatitis was suspected in the early 1980s (3).All cancer registries in Japan have clearly shown significant increases in HCC because of non-HBV-related cases.HBsAgpositive patients accounted for more than 40% of all HCC cases in the early 1970s, when testing was by the h i v e d November 20,
Diphenylhydantoin and the Beta Cell
Authors: Ronald A. Arky
Journal: New England Journal of Medicine (1972)

AT a time when physicians are constantly being cautioned about the complications that arise from the interaction of several pharmacologic agents, it seems appropriate to cite another aspect of the problem relating to the use of therapeutic compounds. Recently, a number of widely used, well established drugs have been shown to distort metabolic processes and even to precipitate new pathologic states. Many of these untoward effects are subtle and proceed unrecognized until florid abnormality develops. The increased recognition of these effects can in part be attributed to refinements in technology that permit detection of small alterations in levels of metabolites . . .
Asthma control or severity: that is the question
Authors: M. Humbert, S. Holgate, L.‐P. Boulet, J. Bousquet
Journal: Allergy (2007)

In the first National Heart Lung and Blood Institute and Global Initiative for Asthma (GINA) guidelines, the level of symptoms and airflow limitation and its variability allowed asthma to be subdivided by severity into four subcategories (intermittent, mild persistent, moderate persistent, and severe persistent). It is important to recognize, however, that asthma severity involves both the severity of the underlying disease and its responsiveness to treatment. Thus, the first update of the GINA guidelines defined asthma severity depending on the clinical features already proposed as well as the current treatment of the patient. In addition, severity is not a fixed feature of asthma, but may change over months or years, whereas the classification by severity suggests a static feature. Moreover, using severity as an outcome measure has limited value in predicting what treatment will be required and what the response to that treatment might be. Because of these considerations, the classification of asthma severity is no longer recommended as the basis for treatment decisions, a periodic assessment of asthma control being more relevant and useful.
Genetic testing for haemochromatosis in patients with chondrocalcinosis
Authors: A E Timms
Journal: Annals of the Rheumatic Diseases (2002)

<h3>ABSTRACT</h3> Myringotomy with ventilation tube placement is a common surgical procedure performed in children and adults to remove fluid build-up behind the tympanic membrane. However, retention of tubes beyond achievement of therapeutic response increases risk for complications and additional intervention. This small feasibility study was conducted to demonstrate proof-of-concept of a novel bioabsorbable ventilation tube that provides the necessary duration of ventilation with absorption shortly thereafter in humans. Tubes were placed in 15 ears of 14 patients meeting indications for short or intermediate-duration of middle ear ventilation. Two independent examiners documented tube patency and tube absorption status at 3, 6 and 12 weeks or until absorption was complete. Results indicate that average ventilation time was 12 weeks (range 3 weeks to 18 months). There was no observation of blockage. These findings support the feasibility of a novel bioabsorbable ventilation tube.
Fibrates in the Treatment of Dyslipidemias — Time for a Reassessment
Authors: Allison B. Goldfine, Sanjay Kaul, William R. Hiatt
Journal: New England Journal of Medicine (2011)

No clinical benefit from modulating high triglyceride levels and low high-density–lipoprotein cholesterol levels with fibrates has been firmly established, though benefit for patients with diabetes and mixed dyslipidemia remains possible.
Perindopril and pulmonary eosinophilic syndrome
Authors: A P Rochford, P R Smith, S J Khan, A J G Pearson
Journal: Journal of the Royal Society of Medicine (2005)

Angiotensin converting enzyme (ACE) inhibitors are responsible for several respiratory effects including cough and angioneurotic oedema but an association with pulmonary eosinophilic syndrome is uncommon.
EXPERIENCES WITH PROTEOSE IN THE TREATMENT OF DISEASES OF THE SKIN
Authors: N. Burgess
Journal: BMJ (1933)

Only four of the cases (8 per cent.) were in women, and of these one was probably primary pleural, one a haemangio-endothelioma, one of the multiple bronchial type, and only one of the common type of bronchial carcinoma.In no one case was the disease found in a patient of the Jewish race.As the City of London Chest Hospital is in the centre of a district in which the Jewish population is large this is somewhat striking.The age incidence is as follows:Years Cases
Pseudoxanthoma Elasticum and Hypertension
Authors: John C. Parker, Alvin E. Friedman-Kien, Sidney Levin, Frederic C. Bartter
Journal: New England Journal of Medicine (1964)

THE low incidence of "essential" hypertension below the age of puberty has become more apparent as diagnostic methods have improved and new etiologic entities have been recognized. Hypertensive children are usually found to have underlying renal, cardiovascular, endocrine, metabolic, toxic or Central-nervous-system disease.1 This report adds pseudoxanthoma elasticum to the list of disorders that may cause high blood pressure in childhood. The case records of 2 sisters are presented below. One died of malignant hypertension at ten years of age and was not seen by us. The other was first discovered to have hypertension at the age of six and . . .
Anaesthetist helps Italian patient who wanted to die
Authors: Fabio Turone
Journal: BMJ (2007)

Piergiorgio Welby, the terminally ill Italian man with muscular dystrophy who in an open letter to the Italian president pleaded for his right to die, has died. 

A few days before Christmas, after a long battle against the illness, he was sedated by an anaesthetist, who unplugged the mechanical ventilator that had kept him alive against his will. 

“My dream, my desire, my request—which I want to put to any authority, from political to judicial ones—is today in my mind more clear and precise than ever: being able to obtain euthanasia,” Mr …
The Effects of Thrombin on Adenyl Cyclase Activity and a Membrane Protein from Human Platelets
Authors: G. N. Brodie, Nancy Lewis Baenziger, Lewis R. Chase, Philip W. Majerus
Journal: Journal of Clinical Investigation (1972)

Washed human platelets were incubated with 0.1-1.0 U/ml human thrombin and the effects on adenyl cyclase activity and on a platelet membrane protein (designated thrombin-sensitive protein) were studied. Adenyl cyclase activity was decreased 70-90% when intact platelets were incubated with thrombin. The T(1/2) for loss of adenyl cyclase activity was less than 15 sec at 1 U/ml thrombin. There was no decrease of adenyl cyclase activity when sonicated platelets or isolated membranes were incubated with these concentrations of thrombin. Loss of adenyl cyclase activity was relatively specific since the activities of other platelet membrane enzymes were unaffected by thrombin. Prior incubation of platelets with dibutyryl cyclic adenosine monophosphate (AMP), prostaglandin E(1), or theophylline protected adenyl cyclase from inhibition by thrombin. Incubation of intact but not disrupted platelets with thrombin resulted in the release of thrombin-sensitive protein from the platelet membrane. The rapid release of this protein (T(1/2) < 15 sec) at low concentrations of thrombin suggested that removal of thrombin-sensitive protein from the platelet membrane is an integral part of the platelet release reaction. This hypothesis is supported by the parallel effects of thrombin on adenyl cyclase activity and thrombin-sensitive protein release in the presence of dibutyryl cyclic AMP, prostaglandin E(1), and theophylline at varying concentrations of thrombin.
Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure
Authors: Takuo Hirose, Kazuhito Totsune, Nobuyoshi Mori, Ryo Morimoto, Masahiro Hashimoto, Yukiko Nakashige, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Junichiro Hashimoto, Hironobu Sasano, Masahiro Kohzuki, Kazuhiro Takahashi, Yutaka Imai
Journal: European Journal of Heart Failure (2008)
Radiofrequency Catheter Ablation of the Atria Reduces Inducibility and Duration of Atrial Fibrillation in Dogs
Authors: Arif Elvan, Harald P. Pride, John N. Eble, Douglas P. Zipes
Journal: Circulation (1995)

Background The purpose of this study was to prevent induction of sustained atrial fibrillation (AF) by radiofrequency catheter ablation (RFCA) of the atria in an open-chest canine model. Methods and Results In dogs randomized to acute studies, RFCA of the atria was performed after reproducible induction of sustained AF (lasting &gt;30 minutes) with burst stimulation or premature atrial pacing and perpetuation by low level cervical vagal stimulation or IV infusion of methacholine. Additionally, in four dogs, the long-term effectiveness of RFCA was assessed 7 to 21 days after ablation. Continuous discrete transmural lesions were produced with radiofrequency energy pulses (20 to 40 W for 60 seconds) delivered to five atrial epicardial sites and endovascularly to the coronary sinus wall. RFCA electrically isolated regions of the atria that became dissociated from the nonisolated parts. Atrial RFCA markedly attenuated vagally induced shortening of effective refractory period (ERP) at both isolated and nonisolated test sites located in the left and right atria ( P &lt;.001, n=5). RFCA rendered noninducible sustained AF maintained by cervical vagal stimulation. The dose-response curve relating the dose of methacholine required to maintain AF was shifted down and to the right. AF was only inducible with high doses of methacholine. Atrial RFCA reduced the maximal sinus rate and prolonged the corrected sinus-node recovery time ( P &lt;.001, n=6). However, RFCA did not affect atrial contractile function, AV-nodal ERP, or AV-nodal or His-Purkinje conduction times. In dogs in the chronic group, normal sinus rhythm and normal AV conduction were preserved and AF was only inducible with a high dose of methacholine. No atrial perforations resulted. Conclusions RFCA in open-chest dogs produces partial vagal denervation and reduces the inducibility of AF.
Use of Google as a diagnostic aid
Authors: Birte Twisselmann
Journal: BMJ (2006)

Use of Google as a diagnostic aid Bias your searchEditor-Although Google can be a valuable aid in reaching diagnoses in rare conditions, 1 the problem faced in a busy, fast-paced clinic can be the abundance of lesser quality material on the web."Biasing" or directing your search by adding the name of an online clinical knowledge base such as Emedicine can lead you to quality information more quickly; you avoid sifting through dozens of unknown journals, personal webpages, blogs, or discussion forums containing your search terms.For example, by typing "pigmented lesion+buccal" into Google you will get 55 000 hits with a vast array of very different material.However, typing "pigmented lesion+buccal+emedicine" provides only 106 hits (accessed 12 November 2006), the first being a comprehensive Emedicine review on Peutz-Jeghers syndrome. 2You get similar results by adding "BMJ" to the end of your search; in this case the top hit is an ABC of oral health article.
Concurrence of Germline Mutations in the <i>APC</i> and <i>PTEN</i> Genes in a Colonic Polyposis Family Member
Authors: L. Valle, R. Rodríguez-López, M. Robledo, J. Benítez, M. Urioste
Journal: Journal of Clinical Oncology (2004)

to inform them about what is happening to cancer care.The MMA Today Web site (which can be accessed via www.asco.org) and other forms of communication have been initiated to keep our US members informed about the rapidly changing developments in this area of public policy.As a physician who cares for patients with cancer, and as an ASCO volunteer, I see every day the benefits that ASCO brings to my patients.As quoted in the Bhagavad Gita, "If I did not work, these worlds would perish."Certainly if each of us does not work to advance the care of our patients, the world of cancer care as we know it will perish.It has been an honor to participate in this important work as an ASCO volunteer and member of the Board of Directors.I call on all of my fellow physicians who are involved in the care of individuals with cancer to join with ASCO to protect the gains we have made for our patients and to continue the battle against cancer.
Women's Health
Authors: Catherine D. DeAngelis, Margaret A. Winker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of weight training on sprinting performance, flexibility and strength
Authors: K Azeem, A Al Ameer
Journal: British Journal of Sports Medicine (2010)

Weight training has motivated and attracted the youth to develop their strength and build their muscles. Apart from developing a wholesome personality it also helps in to keep a person fit and healthy. The purpose of the study was to find out the effect of weight training (WT) on sprinting performance, flexibility and strength of the 20 students. A 45 min WT schedule twice a week for 12 weeks was administered. The test considered were strength (1 RM for all the WT components), 50 m run and sit and reach. Speed is one of the variables which is associated with the fitness of the subjects. The analysis of the data reveals a significant (p&lt;0.05) improvement sprinting performance with the mean±SD reading in the pre-test 0.43±0.07 s and in the post-test of 0.41±0.06 s. Flexibility improved (p&lt;0.05) from pre to post test (26.7±9.3) and (31.8±8.4). Squat exercise increased (p&lt;0.05) from pre to post test (75.5±15.1 kg) and (99.5±14.7 kg). The bench press exercise increased (p&lt;0.05) from pre to post test (48.8±24.1) and (65.5±24.3 kg). Barbell front press exercise increased (p&lt;0.05) from pre to post test (24.5±12.7 kg) and (34.4±12.4 kg). High pull downs improved the strength of the lats and back muscles, and the analysis points towards it with from pre to post test (39.5±11.1 kg) and (59.0±10.3 kg; p&lt;0.05). Barbell curls exercise increased (p&lt;0.05) the strength of the biceps muscles from pre to post test (17.3±7.3 kg) and (27.0±7.9 kg). The study has revealed that WT improved strength and also showed some improvement in speed and flexibility.
The Surgery of the Jejunum
Authors: J. Adams
Journal: BMJ (1926)

To the anatomiist the jejunuim is the upper two-fifths of small initestine; to the surgeoni it is that portion which Legins at tihe dutodeno-jejunal flexure alnd does not desceid into the pelvis.Traunwatc Lesiots.Although the jejunum is nowhere protected by alty covering but musele the incidence of small intestin3e rupture is about equial in both jejunum.and ileum.It be that the relative emptiness of the jejunumi affords some immunity.If it is accepted that the three possible mechanismns-a crush, a tear, or a burst-are the factors responsible for intestinal rupture, I think we may it that the last very rarely affects the jejunum.Undoubtedly fixed portions of the intestine are most suseeptible