tbuckley/cabot-search huggingface dataset:
Ultracentrifugal Demonstration of Floating Beta Lipoproteins in Type III Hyperlipoproteinemia
Authors: FRANCINE AUBRY
Journal: Annals of Internal Medicine (1971)

A 60-year-old woman with angina pectoris, discrete planar and tuberous xanthomas, and diffuse yellow orange pigmentation of the palms had both hypercholesterolemia and hypertriglyceridemia. On paper electrophoresis her plasma lipoprotein pattern was indistinguishable from that of hyperbetalipoproteinemia (type II). Carbohydrate feeding elicited a type IV pattern. Ultracentrifugal analysis of the plasma showed an abnormal beta lipoprotein floating at density 1.006. This anomaly persisted after normalization of plasma lipids by the administration of ethyl 2-(p-chlorophenoxy)-2-methylpropionate. Investigation of the kindred and the absence of secondary causes to account for the hyperlipidemia were also consistent with the diagnosis of primary type III hyperlipoproteinemia. The criteria for diagnosis of type III hyperlipoproteinemia are reviewed and the danger of relying on the paper electrophoretic pattern alone is emphasized. The diagnosis of type III disease should not be made until the presence of "floating" beta lipoprotein is demonstrated by ultracentrifugation.
Phenformin, Tetracycline and Lactic Acidosis
Authors: P. J. Phillips, R. W. Pain, G. Easterbrook
Journal: Annals of Internal Medicine (1977)

Comments1 January 1977Phenformin, Tetracycline and Lactic AcidosisP. J. PHILLIPS, M.B., B.S., M.A.(OXON), M.R.A.C.P., R. W. PAIN, M.B., B.S., F.R.C.P.A., G. EASTERBROOK, B.PHARM.P. J. PHILLIPS, M.B., B.S., M.A.(OXON), M.R.A.C.P.Search for more papers by this author, R. W. PAIN, M.B., B.S., F.R.C.P.A.Search for more papers by this author, G. EASTERBROOK, B.PHARM.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-111_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Blumenthal and Streeten (Ann Intern Med84:55-56, 1976) of the association between the biguanide phenformin, the antibiotic tetracycline, and serious lactic acidosis is similar to one by Tashima (1). In both cases the patient was young and had no evidence of cardiovascular or hepatic dysfunction, and the dose of phenformin was not excessive (250 and 100 mg/day, respectively). The latter case was fatal, and there was postmortem evidence of bilateral chronic pyelonephritis. In neither case were serum or tissue phenformin concentrations measured. One patient of Tranquada and associates' (2) three cases with irreversible lactic...References1. TASHIMA C: Phenformin, tetracycline and lactic acidosis. Br Med J 4:557-558, 1971 CrossrefMedlineGoogle Scholar2. TRANQUADABERNSTEINMARTIN RSH: Irreversible lactic acidosis associated with phenformin therapy. JAMA 184:37-42, 1963 CrossrefMedlineGoogle Scholar3. SHILS M: Some metabolic aspects of tetracyclines. Clin Pharmacol Ther 3:321-339, 1962 CrossrefMedlineGoogle Scholar4. PHILLIPSWILLIAMSKWITKO PRA: Beguanide effects on lactate metabolism. Aust NZ J Med 6:174, 1976 Google Scholar5. BLACOWWADE NA (eds.): Martindale: The Extra Pharmacopoeia, 26th ed. London, The Pharmaceutical Press, 1972, p. 1432 Google Scholar6. ROOTHBANDMAN RU: Renal response to acid load after phenformin. Br Med J 4:256-257, 1973 CrossrefMedlineGoogle Scholar7. WAHRENHAGENFELDTFELIG JLP: Splanchnic and leg exchange of glucose, amino acids and free fatty acids during exercise in diabetes mellitus. J Clin Invest 55:1303-1314, 1975 CrossrefMedlineGoogle Scholar8. DOARCRAMP JD: The effects of obesity and maturity onset diabetes mellitus on L (+) lactic acid metabolism. Clin Sci 39:271-279, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDiabetes MellitusInsulin, glucagon and oral hypoglycaemic drugs 1 January 1977Volume 86, Issue 1Page: 111-111KeywordsAntibioticsAttentionLactic acidosisPyelonephritisTetracyclines Issue Published: 1 January 1977 PDF DownloadLoading ...
Physicians should contribute to preventing nuclear war
Authors: T. C. Chalmers
Journal: JAMA (1984)

To the Editor.—  Physicians can appreciate as few others the untreatable suffering that would follow a nuclear war. They also understand the longterm effects on health and welfare of an escalating arms race that may end when only one side commits a grave error.  This reasoning resulted in the founding of the  Physicians for the Prevention of Nuclear War; membership now includes more than 100,000 physicians in 53 countries. The fourth annual congress at Helsinki in June 1984 reported that more than 25% of the world's physicians had signed the following International Physicians' Call for an End to the Nuclear Arms Race:  As physicians, we wish to express our professional concern over the unprecedented threat to life and health posed by nuclear weapons, a threat that hangs over hundreds of millions of people. The increasing accumulation of destructive power and the development of ever more sophisticated weapons greatly increase
Arterial Blood Gas Tensions and pH During Attacks of Bronchial Asthma.
Authors: Felix M. Cortes
Journal: Annals of Internal Medicine (1966)

s1 May 1966Arterial Blood Gas Tensions and pH During Attacks of Bronchial Asthma.Felix M. Cortes, M.D. (Associate), Richard Mitchell, M.D., William Fewell, M.D., Howard Baier, M.D.Felix M. Cortes, M.D. (Associate)Search for more papers by this author, Richard Mitchell, M.D.Search for more papers by this author, William Fewell, M.D.Search for more papers by this author, Howard Baier, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1180_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptForty-eight patients presenting themselves to the emergency department with attacks of bronchial asthma were selected for studies. On examination all the patients were experiencing moderate to severe respiratory distress with prolonged expiratory phase and diffuse expiratory wheezes. Arterial blood for determination of pH, PCO2 and PO2 was obtained before any treatment was instituted.The results revealed that based on the arterial gas tension and pH, these patients fell into various groups: (1) normal findings (7 cases), (2) arterial unsaturation with normal PCO2(21 cases), (3) respiratory acidosis (10 cases), (4) respiratory alkalosis (10 cases). These studies show some of the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1180-1180KeywordsArterial blood gasAsthmaBloodEmergency departmentPartial pressure of carbon dioxidePartial pressure of oxygen Issue Published: 1 May 1966 PDF DownloadLoading ...
CLINICAL AND ANGIOGRAPHIC OUTCOMES OF BIODEGRADABLE POLYMER BIOLIMUS-ELUTING STENTS VERSUS DURABLE POLYMER ZOTALOLIMUS-ELUTING STENTS WITH 6 MONTHS DUAL ANTIPLATELET THERAPY; ASSOCIATED WITH OPTICAL COHERENCE TOMOGRAPHY SUBSTUDY
Authors: Byoung Kwon Lee, Hyuck Moon Kwon, Young Won Yoon, Pil-Ki Min, Bum-Kee Hong, Myeong-Ki Hong, Yang Soo Jang, Byeong Keuk Kim, Sungwoo Kwon
Journal: Journal of the American College of Cardiology (2014)
A 5-year (1989–1993) Prospective Study of the Incidence of IDDM in Rome and the Lazio Region in the Age-Group 0–14 years
Authors: L Sebastiani, N Visalli, E Adorisio, M A Suppa, R Buzzetti, A L De Cicco, C Giovannini, M D Comerci, M Negri, P Pozzilli
Journal: Diabetes Care (1996)

OBJECTIVE To provide data on the incidence of IDDM in Rome and the Lazio region evaluated prospectively from 1989 to 1993 for a total of &amp;gt; 5 million subjects younger than 15 years. RESEARCH DESIGN AND METHODS All patients with newly discovered IDDM diagnosed between 1 January 1989 and 31 December 1993 among residents in Rome and its region were recorded. Primary ascertainment was based in diabetes clinics and specialized hospitals in the region, whereas the secondary independent source was taken from the archives of the region where patients are registered to obtain exemption from paying for medications. RESULTS We identified 330 new patients with a degree of ascertainment of 85%. Overall the incidence rate of the disease was 7.9 per 100,000 per year (95% CI 7.1–8.8). The incidence was higher in the 5- to 9-year-old age-group (10.4 per 100,000) and in winter (36.2%). The cumulative risk for the disease is on the order of 1.18 per 1,000 subjects &amp;lt; 15 years of age. No significant differences in incidence were observed between boys and girls. There were 14 instances of coma at diagnosis (4.3%), but hyperglycemia without ketonuria was diagnosed in 35% of patients, suggesting an early diagnosis. DISCUSSION Compared with the other continental Italian regions for which data are available for a single year, the IDDM incidence rate in Rome is similar. We conclude that the IDDM incidence rate in Rome and its region is comparable to that in other Southern European countries and remained stable over the 5-year observation period.
Normal Gram Stains
Authors: Richard H. Parker
Journal: JAMA (1965)

<h3>To the Editor:—</h3> I am confused by the statement, "physicians must generally be relieved—and occasionally elated—to find a normal spinalfluid sugar content and normal gram stain in a patient who has symptoms of meningitis" in the editorial entitled "Viral Meningitis," in the April 26, 1965, issue ofThe Journal(<b>192</b>:322). My confusion results from the fact that I do not know what a "normal gram stain" consists of. It is my understanding that the correct reporting of the examination of cerebrospinal fluid, by gram-staining, should consist of either "no microorganisms seen, gram-positive, or gram-negative bacteria seen." I would appreciate your comments on this subject.
An Epidemic of Urinary Tract Infections?
Authors: Walter E. Stamm
Journal: New England Journal of Medicine (2001)

Community-acquired urinary tract infections occur mostly in women, are generally caused by Escherichia coli, and are among the most common bacterial infections. For the past two decades, trimethoprim–sulfamethoxazole or trimethoprim alone has been used widely as empirical therapy for E. coli urinary tract infection. However, in the United States, resistance to trimethoprim–sulfamethoxazole among E. coli isolates from persons with community-acquired urinary tract infections has increased substantially over the past decade, with a prevalence that now exceeds 20 percent in many parts of the country.1 The prevalence of such resistance is substantially higher in the West (22 percent) than in the . . .
Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching
Authors: Sandro Banfi, Giuseppe Borsani, Elena Rossi, Loris Bernard, Alessandro Guffanti, Francesca Rubboli, Anna Marchitiello, Sabrina Giglio, Elisabetta Coluccia, Massimo Zollo, Orsetta Zuffardi, Andrea Ballabio
Journal: Nature Genetics (1996)
Regulating nursing homes: Caring for older people in the private sector in England
Authors: S. H Kerrison, A. M Pollock
Journal: BMJ (2001)

This is the last in a series of three articles 

Over half of all beds allocated for health care in the United Kingdom are in independent nursing homes for older people; this is a result of policies initially introduced to change the basis of social security payments1 and now directed towards privatising long term care. Official statistics from the Department of Health indicate that between 1979 and 2000 the total number of beds in the NHS in England decreased from 480 000 to 189 000, while the number of beds in the independent sector, which is run mainly for profit, increased from 23 000 in 19832 to 193 000 in 2000.

Experiences in the United States and Australia have shown the lack of political will to promote the interests of residents against the interests of the industry and its shareholders. 3 4 In Australia the industry successfully lobbied to replace legally enforceable regulations with less effective accreditation schemes; this has had disastrous consequences. In the United States the industry successfully opposed the introduction of robust standards for minimum numbers of staff, and the result is continuously declining health outcomes for residents. The risks to residents of nursing homes in the United Kingdom are considerable as subsidiaries of large US multinationals enter the United Kingdom5; some of these companies have come under scrutiny in the United States for fraud and embezzlement of government funds and for abusing patients.3 This paper considers whether the new regulatory framework for nursing homes in the United Kingdom offers adequate protection for patients.

#### Summary points

Over half of the healthcare beds in the United Kingdom are in independent nursing homes for older people

Little information is collected centrally about the needs for care or outcomes of services used by residents of nursing homes …
Larynx Preservation for Patients With Locally Advanced Laryngeal Cancer
Authors: June Corry, Lester Peters, Stephen Kleid, Danny Rischin
Journal: Journal of Clinical Oncology (2013)

A 53-year-old man presented with a 6-month history of mild hoarseness, with no associated pain, dysphagia, or stridor. At nasoendoscopy, a lesion was detected involving the whole length of the left vocal cord, with abnormal mucosa also seen in the right ventricle (Fig 1). The left vocal cord movement was impaired. There were no palpable neck nodes. Biopsy under anesthesia revealed moderately differentiated squamous cell carcinoma. He was a current smoker of 30 cigarettes per day (45 pack-year smoking history), and he consumed four standard drinks of alcohol per day. His Eastern Cooperative Oncology Group performance status was 1, and he had no significant comorbidities. Radiologic review of his outside computed tomography scan noted that it was of poor quality, and a magnetic resonance imaging scan was recommended, which showed low-volume T4a disease based on focal thyroid cartilage penetration (Fig 2). A positron emission tomography (PET) scan revealed no evidence of nodal or distant metastasis.
Bullous Erythema Multiforme With Benign Neoplasm
Authors: Rodney S.W. Basler
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Interest has only recently been raised by the association of generalized bullous eruptions with benign tumors.<sup>1</sup>A radiographically-diagnosed benign leiomyoma of the stomach was discovered during an extensive clinical work-up in a patient with chronic debilitating erythema multiforme bullosum and was removed. The patient immediately improved and currently is free of lesions. <h3>Report of a Case.—</h3> The patient first noted an eruption of blisters on an erythematous base beginning over the arms, legs, dorsal fingers, toes, and mouth in April 1971. Triamcinolone acetonide injections controlled the process to a few scattered lesions. However, in March 1972, the vesiculation again extended to the thighs, upper arms, abdomen, back, and palms to involve about 60% of the body surface. There were no mucous membrane or conjunctival lesions. Corticosteroid treatment failed to control the process. The uterus and cervix had been surgically removed. The skin showed well-marginated, circinate, erythematous
Recurrent BRAF mutations in Langerhans cell histiocytosis
Authors: Gayane Badalian-Very, Jo-Anne Vergilio, Barbara A. Degar, Laura E. MacConaill, Barbara Brandner, Monica L. Calicchio, Frank C. Kuo, Azra H. Ligon, Kristen E. Stevenson, Sarah M. Kehoe, Levi A. Garraway, William C. Hahn, Matthew Meyerson, Mark D. Fleming, Barrett J. Rollins
Journal: Blood (2010)
SARS may have peaked in Canada, Hong Kong, and Vietnam
Authors: J. Parry
Journal: BMJ (2003)

The outbreak of severe acute respiratory syndrome (SARS) seems to have peaked in Canada, Hong Kong, Singapore, and Vietnam, according to the World Health Organization. Worldwide 5242 cases and 321 deaths were reported by 28 April in 28 countries, and concern is growing that the disease will become endemic in some countries if it is not brought under control soon.

However, in 23 countries the disease has been well contained, said Dr Mike Ryan, WHO's coordinator of the global outbreak alert and response network. “In a country like China, with a very large population, there is a possibility that disease can become established and remain in human populations, but we do have an opportunity to break the cycle of transmission in this disease and put it back in the box,” he said.

The numbers in China are expected to continue to climb in the coming weeks. “We think Beijing is a major, major black spot,” said Mr Peter Cordingley, spokesman for WHO's Manila office. By 27 April 1114 cases and 56 deaths had been reported there, and Beijing looks …
The New Vital Sign
Authors: Michael C. Fiore
Journal: JAMA (1991)

AT THE turn of the last century, the American medical community developed a standardized assessment to help clinicians confront the leading cause of death at that time, infectious disease. This assessment, known as vital signs, included temperature, pulse rate, respiratory rate, and, later, blood pressure.<sup>1-3</sup>Over time, the measurement of vital signs became an expected part of every clinic visit and an essential component of the database physicians use to evaluate, diagnose, and treat patients. As we approach the next century, American medicine is challenged by a different cause of illness and death—tobacco use. Cigarettes are now responsible for more than 430000 deaths each year in the United States.<sup>4</sup>As with past epidemics of this magnitude, institutional changes in the practice of medicine must be adopted to overcome the enormous disease burden resulting from tobacco use. Making smoking status the "new vital
Arginine-engrafted biodegradable polymer for the systemic delivery of therapeutic siRNA
Authors: Jagadish Beloor, Chang Seon Choi, Hye Yeong Nam, Minsun Park, Sung Hwa Kim, Andrew Jackson, Kuen Yong Lee, Sung Wan Kim, Priti Kumar, Sang-Kyung Lee
Journal: Biomaterials (2011)
Treatment of Carcinoma of the Tongue
Authors: Roland G. Ware
Journal: JAMA (1965)

Dr. Joseph T. Ferrucci, Jr.: A 70-year-old white man was first seen three years ago complaining of progressive soreness and swelling of his tongue, of at least two years' duration. He gave a long history of pipe smoking. A Hinton test gave positive results. There was a lesion diffusely infiltrating the dorsum of the tongue without fixation to the floor of the mouth. Only the very tip of the tongue anteriorly, the left lateral margin, and the volume behind the circumvallate papillae were spared. The tonsilingual folds throughout were clear. There was no evidence of metastatic disease. Biopsy showed squamous-cell carcinoma.  Discussion  Dr. Milford D. Schulz: What does syphilitic glossitis mean as far as your treatment plan is concerned, Dr. Wang?  Dr. C. C. Wang: A small carcinoma associated with syphilitic glossitis should be treated by excision rather than radiotherapy. A second lesion tends to develop in these patients. In
What is a good GP?
Authors: A Leck, I Leck
Journal: BMJ (1987)

The good GP will treat patients both as people and as a population. Treating patients as peopleIt has been said that "though sometimes 'what is the illness' is the question dominating the doctor's task, 'who is ill' is what is usually crucial to patient care."'What this implies for good practice falls under the following four headings.Assessing patients' problems realistically-Making a precise diag- nosis is not always necessary or always sufficient.It is all too easy to focus on a disease process in one part of the body and to neglect the "owner"2 of the body and his or her physical, psychological, and social circumstances in their entirety.Unless these aspects are considered, not only may many factors that affect the aetiology and natural history of the disease and the choice and effectiveness of treatment go unnoticed, but so may the patient's real reasons for consulting the GP.Responding realistically to patients' problems-Just as the assess- ment of patients' problems should often include more than clinical diagnosis, so should the response entail far more than prescribing drugs and referring to consultants.It may, for example, mean helping the patient to get financial, psychological, or social support.Of course, the GP cannot be self sufficient in these areas: he or she must recognise, respect, and use intelligently the skills not only of hospital consultants but also of non-doctors in the primary care team, in departments of social services, and in voluntary agencies
Factors associated with the donation and non-donation of embryos for research: a systematic review
Authors: Catarina Samorinha, Margarida Pereira, Helena Machado, Bárbara Figueiredo, Susana Silva
Journal: Human Reproduction Update (2014)

Systematic knowledge on the factors that influence the decisions of IVF users regarding embryo donation for research is a core need for patient-centred policies and ethics in clinical practice. However, no systematic review has been provided on the motivations of patients who must decide embryo disposition. This paper fills this gap, presenting a systematic review of quantitative and qualitative studies, which synthesizes the current body of knowledge on the factors and reasons associated with IVF patients' decisions to donate or not to donate embryos for research. A systematic search of studies indexed in PubMed, ISI WoK and PsycINFO, published before November 2013, was conducted. Only empirical, peer-reviewed, full-length, original studies reporting data on factors and reasons associated with the decision concerning donation or non-donation of embryos for research were included. Eligibility and data extraction were performed by two independent researchers and disagreements were resolved by discussion or a third reviewer, if required. The main quantitative findings were extracted and synthesized and qualitative data were assessed by thematic content analysis. A total of 39 studies met the inclusion criteria and were included in the review. More than half of the studies (n = 21) used a quantitative methodology, and the remaining were qualitative (n = 15) or mixed-methods (n = 3) studies. The studies were derived mainly from European countries (n = 18) and the USA (n = 11). The proportion of IVF users who donated embryos for research varied from 7% in a study in France to 73% in a Swiss study. Those who donate embryos for research reported feelings of reciprocity towards science and medicine, positive views of research and high levels of trust in the medical system. They described their decision as better than the destruction of embryos and as an opportunity to help others or to improve health and IVF treatments. The perception of risks, the lack of information concerning research projects and the medical system and the conceptualization of embryos in terms of personhood were the most relevant motives for not donating embryos for research. Results relating to the influence of sociodemographic characteristics and reproductive and gynaecological history were mostly inconclusive. Three iterative and dynamic dimensions of the IVF patients' decision to donate or not to donate embryos for research emerged from this review: the hierarquization of the possible options regarding embryo disposition, according to the moral, social and instrumental status attributed to embryos; patients' understanding of expectations and risks of the research on human embryos; and patients' experiences of information exchange and levels of trust in the medical-scientific institutions.