tbuckley/cabot-search huggingface dataset:
Calcification of the Aorta and Osteoporosis
Authors: Rafik Boukhris
Journal: JAMA (1972)

X-ray films of 589 persons studied to determine the relationship between osteoporosis and calcification of the abdominal aorta showed the prevalence of osteoporosis to be 24.1%, being highest in white females (39.2%). White females had a greater prevalence than black females, and white males more than black males. In contrast to white males, in whom osteoporosis became common after the age of 55 years, white females demonstrated a high frequency a decade earlier. The prevalence of patients with calcification of the abdominal aorta was 20.2%, the highest being in white females (28%). Statistical analysis demonstrated a positive correlation between the two conditions. The association is present also after the effects of age have been removed statistically. Perhaps the loss of calcium from bone which occurs in osteoporosis predisposes to calcification of the abdominal aorta.
Who are we treating?
Authors: F. Godlee
Journal: BMJ (2014)

When we offer palliative chemotherapy to a terminally ill patient, who are we treating, the patient or the doctor? How clearly do we understand the consequences of this treatment decision, and how well do we explain these to the patient and their family?

A study just published in the BMJ indicates that we underestimate the risks of giving palliative chemotherapy in the few months before death. The aim of treatment may be to prolong life by a few weeks, which is what many patients most want, or to manage symptoms and improve quality of life. But the unwanted outcome may be a worse, more …
Bevacizumab must be specially prepared for intraocular use
Authors: I. Georgalas, D. Papaconstantinou, T. Paraskevopoulos, C. Koutsandrea
Journal: BMJ (2013)

Torjesen clearly sums up the results of a recent trial showing that off-label use of bevacizumab (Avastin) is as effective as the more expensive licensed treatment for wet age related macular degeneration—ranibizumab (Lucentis).1 2 This will provide an …
Diagnosis and Treatment of Cardiac Arrhythmias
Authors: David H. Spodick
Journal: JAMA (1970)

In 234 pages (including a good index), Dr. Stock has produced a remarkable textbook on dysrhythmias which compresses an enormous amount of theoretical and practical data without sacrificing "readability." In the diagnostic half (125 pages) he has succeeded in presenting the essence of what can be found in several of the standard weighty tomes on the subject. All the important theoretical concepts are touched on and the criteria for diagnosis of individual rhythm disorders are completely set forth with a clarity which is unusual for this subject matter. The discussion of controversies is particularly enlivened by the author's personal views, which are always closely reasoned. The therapeutic sections move from generalities to specific recommendations, in each clinical setting providing a plan of action within a context relating dysrhythmia mechanisms to the physiology and pharmacology of the agents used. Tables and diagrams are clear and adequate in numbers, as are illustrative
Suprasternal notch echocardiography: a two-dimensional technique for evaluating congenital heart disease.
Authors: A R Snider, N H Silverman
Journal: Circulation (1981)

Two-dimensional suprasternal notch echocardiography was performed in 1033 patients, ages 1 day to 18 years. For the long-axis suprasternal notch view, the transducer was positioned in the suprasternal notch and angled to obtain a plane passing between the right nipple and left scapular tip. In this view, the entire aortic arch, vessels to the head and neck, right pulmonary artery and right bronchus were imaged. The long-axis view was useful for evaluating coarctation and interruption of the aorta, hypoplastic left heart, aortic and pulmonic stenosis and cervical aortic arch. For the short-axis suprasternal notch view the transducer was positioned in the suprasternal notch and angled to obtain a coronal body plane. In this view the transverse aorta, right pulmonary artery, left atrium, innominate veins and superior vena cava were imaged. The short-axis view was useful in the evaluation of children with increased or decreased pulmonary blood flow, persistent left superior vena cava, total anomalous pulmonary venous return to the right superior vena cava, and superior vena caval obstruction after Mustard's operation. In the evaluation of children with congenital heart disease, the suprasternal notch views added significant information to the two-dimensional echocardiographic examination.
NHS could help boost local communities, says Kings Fund
Authors: L. Eaton
Journal: BMJ (2002)

The NHS—the largest employer and one of the biggest purchasers in the United Kingdom and a huge consumer of energy and creator of waste—could do far more to address the overall health and wellbeing of local communities, says a report from a group of leading academics.

The NHS's potential impact on health, the environment, and the social and economic fabric of our lives is without parallel, says the report from the King's Fund, a leading think tank based in London.

The report, edited by Anna Coote, the King's Fund's director of public health, says that the NHS needs to move away from what it terms “destructive cycles”—where resources are used in ways that are wasteful and potentially damaging to people's health and the environment.

In their place, it says, should be a “virtuous circle,” whereby patterns of behaviour promote economic, social, and environmental sustainability and also improve health, especially among people …
TETANUS PUERPERARUM.Read in the Section on Obstetrics and Diseases of Women at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: ALLISON MAXWELL
Journal: JAMA (1894)

Mrs. Jas. H. D., aged 29, mother of five children, was confined at term Oct. 13, 1893. She had always been a strong healthy woman. She was attended during labor by her husband, who was a laboring man, and by a woman next door. Her husband told me he had been instructed in such matters by his physician where he lived in Illinois when the other children were born. A healthy child was born, and she went through her confinement, her husband stated, easier and felt better afterward than she had in previous confinements. I asked him in regard to the expulsion of the placenta, and he said he had examined it carefully and it seemed to be all there. On the ninth day after confinement there was some aching and drawing about the fauces. On the tenth and eleventh days she seemed to feel better again. On the twelfth
Beta-carotene treatment of erythropoietic protoporphyria
Authors: M.F. Corbett, I.A. Magnus, A. Herxheimer, C.A. Ramsay
Journal: British Journal of Dermatology (1979)

Journal Article Beta‐carotene treatment of erythropoietic protoporphyria Get access M.F. Corbett, M.F. Corbett Department of Photobiology, Institute of Dermatology, London Search for other works by this author on: Oxford Academic Google Scholar I.A. Magnus, I.A. Magnus Department of Photobiology, Institute of Dermatology, London Search for other works by this author on: Oxford Academic Google Scholar A. Herxheimer, A. Herxheimer Departments of Pharmacology and Medicine, Charing Cross Hospital Medical School, London Search for other works by this author on: Oxford Academic Google Scholar C.A. Ramsay C.A. Ramsay Photobiology and Therapy Unit, Toronto Western Hospital, Ontario, Canada Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 101, Issue 6, 1 December 1979, Pages 732–733, https://doi.org/10.1111/j.1365-2133.1979.tb05657.x Published: 01 December 1979
Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity
Authors: Iris Bellinghausen, Sebastian Reuter, Helen Martin, Joachim Maxeiner, Uli Luxemburger, Özlem Türeci, Stephan Grabbe, Christian Taube, Joachim Saloga
Journal: Journal of Allergy and Clinical Immunology (2012)
An MRCGP course for trainees in the West Midlands region.
Authors: D W Wall
Journal: BMJ (1984)

I describe a course for trainees in Birmingham and Lichfield in January 1983 to prepare them for the summer examination for membership of the Royal College of General Practitioners. The trainees rated the course highly in both centres, and in particular liked the small group work for the oral examinations. Of 24 trainees who attended, however, only 15 sat and 11 passed the examination. I describe the course content and discuss the possible reasons for the small number of trainees going on to sit the MRCGP examination.
Continuous Subcutaneous Insulin Infusion (Mill-Hill Infuser) Versus Multiple Injections (Medi-Jector) in the Treatment of Insulin-dependent Diabetes Mellitus and the Effect of Metabolic Control on Microangiopathy
Authors: J -L Chiasson, F Ducros, M Poliquin-Hamet, D Lopez, L Lecavalier, P Hamet
Journal: Diabetes Care (1984)

The present study was designed to compare continuous subcutaneous insulin infusion (CSII) using the Mill-Hill Infuser (Muirhead Medical Products Ltd., London, England) with multiple injections (MI) using the Medi-Jector (Derata Corporation, Minneapolis, Minnesota)in the treatment of insulin-dependent diabetes mellitus (IDDM), and to assess the effect of glucose control on diabetes complications. Twelve diabetic subjects were treated 3 mo with CSII and 3 mo with MI (bedtime ultralente and premeal boluses of regular insulin) ina randomized fashion. Prestudy preprandial/postprandial glucose levels were 147–215 mg/dl and improved to 108–138 mg/dl during CSII, and to 115–139 mg/dl during MI with glycosylated hemoglobin of 12.9%, 9.1%, and 8.7%, respectively. This improved glucose control with either CSII or MI was associated with an increase in sural nerve conductivity from 42.9 to 45 m/s and a decrease in proteinuria from 1.9 to 0.5 g/24 h. The 24-h insulin dose consisted of 45 U before the study, 44 U during CSII, and 56 U during MI. After the study, seven patients opted to continue with the Mill-Hill Infuser, and five with the Medi-Jector. We conclude the following: (1) treatment with both the Mill-Hill Infuser and the Medi-Jectorwas well accepted by the patients and resulted in similar improvement in measured blood glucose and glycosylated hemoglobin; (2) this improved metabolic control was associated with an increased nerve conductivity and a decreased protein excretion; and (3) MI required20% more insulin than CSII to achieve similar glycemic control.
C5aR, TNF-α, and FGL2 contribute to coagulation and complement activation in virus-induced fulminant hepatitis
Authors: Jianjun Liu, Yulong Tan, Jinyu Zhang, Liyun Zou, Guohong Deng, Xueqing Xu, Feng Wang, Zhengwei Ma, Jue Zhang, Tingting Zhao, Yunlai Liu, Yongsheng Li, Bo Zhu, Bo Guo
Journal: Journal of Hepatology (2014)
Letter: Prolactin and uric acid in man.
Authors: R A Branch, D Levine, R Auty, E Cole, L Ramsay
Journal: BMJ (1975)

product of the gonads by reflex muscular effort, or it is that reflex which would expel these products were they present in sufficient quantity and were the appropriate pathways clear.This activity is known as ejaculation and the female has no homologue of this activity, which is unique to the male.-Iam, etc.,
Newborns with Myelodysplasia — The Rest of the Story
Authors: Richard H. Gross
Journal: New England Journal of Medicine (1985)

This year has seen a notable attentiveness toward the problem of the newborn with birth defects, specifically myelomeningocele. In the legal sphere, the new child-abuse act legislates against "withholding of medically indicated treatment" unless (1) the infant is irreversibly comatose, (2) the provision of such treatment would merely prolong dying, or (3) the provision of such treatment would be virtually futile in terms of the infant's survival and the treatment itself would be inhumane.1 Two articles published this year update previously reported experience from centers with a long-standing interest in spina bifida. Charney et al. have validated the concept that . . .
Nairobi summit opens with call for action for landmine survivors
Authors: Peter Moszynski
Journal: BMJ (2004)

The largest ever gathering of survivors of landmines this week called on states to solidify their commitment to the implementation of the Mine Ban Treaty of 1997 and to work towards greater help for people with disabilities.

The 40 survivors, from 33 countries, were attending a landmine survivors meeting, which was part of the Nairobi summit on a mine free world, which opened in Kenya on Sunday.

Ken Rutherford, cofounder of the Landmine Survivors Network, pointed out, “The mine ban treaty aimed at the full social and economic reintegration of landmines survivors but this will only …
Cholecystokinin release and biliopancreatic secretion in response to selective perfusion of the duodenal loop with aminoacids in man.
Authors: J F Colombel, A Sutton, J A Chayvialle, R Modigliani
Journal: Gut (1988)

The aim of this study was to measure the role of the duodenal loop in biliopancreatic secretion in man by infusing various stimuli at the ampulla of Vater and collecting duodenal contents at the ligament of Treitz, above an occluding balloon. Perfusion at 10 ml/min of a first mixture of aminoacids - phenylalanine (47.2 mmol), methionine (38.2 mmol), tryptophan (11 mmol), valine (61.6 mmol) - increased cholecystokinin (CCK) plasma concentrations and duodenal bile salt output (p less than 0.005) as compared with a control electrolyte solution, but did not change pancreatic enzyme secretion significantly; duodenal infusion of another aminoacid mixture - arginine (32.4 mmol), histidine (14.1 mmol), leucine (36 mmol), isoleucine (21.5 mmol), lysine (31 mmol), threonine (23 mmol) - did not change CCK plasma concentrations, bile salt or pancreatic enzyme output. The respective role of duodenal distension and endogenous CCK was investigated by perfusing the first aminoacid solution and the control solution at 2, 5, and 10 ml/min. Changing the perfusion rate of control solution from 2 to 5 ml/min led to a significant increase (p less than 0.01) in pancreatic secretion with no further increase at 10 ml/min. Bile salt output was not influenced by the perfusion rate of control solution. During the perfusion of the aminoacid solution, despite a stepwise increase in CCK release, the only significant change in pancreatic secretion was an increase of lipase output (p less than 0.05) when the infusion rate was raised from 2 to 5 ml/min. Our results suggest that duodenal CCK release (1) depends on the nature of aminoacids (2) has predominant role in the regulation of pancreatic secretion at low perfusion rate but is less effective when superimposed on a mechanical stimulus caused by duodenal distension (3) is a major stimulus for gall bladder contraction which is not influenced by duodenal distension.
Genistein: does it prevent or promote breast cancer?
Authors: K B Bouker, L Hilakivi-Clarke
Journal: Environmental Health Perspectives (2000)

Diet is estimated to contribute to approximately 50% of all newly diagnosed breast cancers. As such, a search for dietary factors differentially consumed among populations with increased breast cancer risk (e.g., Caucasians) compared to those with low risk (e.g., Asians) has become a priority. One such dietary component, which is typical to the Asian but not the Caucasian diet, is soy. We review data relevant to attempts to determine whether soy, and more specifically genistein, is a dietary component that may help to explain the dramatic disparity in breast cancer risk among these populations.
(30) Case for diagnosis
Authors: J. Dawson, D. Burrows
Journal: British Journal of Dermatology (1984)

Journal Article (30) Case for diagnosis Get access J. Dawson, J. Dawson Royal Victoria Hospital, Belfast Search for other works by this author on: Oxford Academic Google Scholar D. Burrows D. Burrows Royal Victoria Hospital, Belfast Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Pages 74–75, https://doi.org/10.1111/j.1365-2133.1984.tb05300.x Published: 01 July 1984
Outlines of Nursing History.
Authors: Minnie Goodnow
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plantar pressure measurements. Rational shoe-wear in patients with rheumatoid arthritis
Authors: J. P. Barrett
Journal: JAMA (1976)

Objective measurements of forefoot plantar pressures were taken on 25 patients with rheumatoid arthritis. The Harris mat footprint test and the Brand slipper sock test were used to assess both compressive shearing forces. The Harris mat footprint test is a static used when the patient is unshod. The Brand slipper sock test is a dynamic test used while the shoe is worn. An experimental sandal was designed and used for the treatment of symptomatic forefoot callosities. The Harris mat footprint test results improved dramatically after the patients had worn an experimental sandal for six months. The Brand slipper sock test results showed marked diminution in the pressure profile while the patients wore the experimental sandal. All of the patients improved in their functional abilities while wearing the experimental sandal.
Bone marrow stroma CD40 expression correlates with inflammatory mast cell infiltration and disease progression in splenic marginal zone lymphoma
Authors: Giovanni Franco, Carla Guarnotta, Barbara Frossi, Pier Paolo Piccaluga, Emanuela Boveri, Alessandro Gulino, Fabio Fuligni, Alice Rigoni, Rossana Porcasi, Salvatore Buffa, Elena Betto, Ada Maria Florena, Vito Franco, Emilio Iannitto, Luca Arcaini, Stefano Aldo Pileri, Carlo Pucillo, Mario Paolo Colombo, Sabina Sangaletti, Claudio Tripodo
Journal: Blood (2014)
Tyrosinase activity in human skin. Influence of race and age in newborns.
Authors: S H Pomerantz, I G Ances
Journal: Journal of Clinical Investigation (1975)

Tyrosinase has been measured in homogenates of foreskins from newborn babies. The tyrosine hydroxylation reaction is dependent upon 3,4-dihydroxyphenylalanine as a cosubstrate, and the Km for tyrosine is 0.15 mM, similar to the value observed for other mammalian tyrosinases. The mean enzyme activity for black babies (n = 169) is about two and one-fourth times that for white babies (n = 82). For white babies there is a significant correlation between age at circumcision and tyrosinase activity. For black babies this correlation becomes significant when four individuals with extremely high tyrosinase activities are omitted from the series.
Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation
Authors: David J. Kittlesen, Kimberly A. Chianese-Bullock, Zhi Qiang Yao, Thomas J. Braciale, Young S. Hahn
Journal: Journal of Clinical Investigation (2000)

Hepatitis C virus (HCV) is an important human pathogen that is remarkably efficient at establishing persistent infection. The HCV core protein is the first protein expressed during the early phase of HCV infection. Our previous work demonstrated that the HCV core protein suppresses host immune responses, including anti-viral cytotoxic T-lymphocyte responses in a murine model. To investigate the mechanism of HCV core-mediated immunosuppression, we searched for host proteins capable of associating with the core protein using a yeast two-hybrid system. Using the core protein as bait, we screened a human T cell–enriched expression library and identified a gene encoding the gC1q receptor (gC1qR). C1q is a ligand of gC1qR and is involved in the early host defense against infection. Like C1q, HCV core can inhibit T-cell proliferative responses in vitro. This core-induced anti–T-cell proliferation is reversed by addition of anti-gC1qR Ab in a T-cell proliferation assay. Furthermore, biochemical analysis of the interaction between core and gC1qR indicates that HCV core binds the region spanning amino acids 188 to 259 of gC1qR, a site distinct from the binding region of C1q. The inhibition of T-cell responsiveness by HCV core may have important implications for HCV persistence in humans.
The in vitro effect of a calf thymus extract on the peripheral blood lymphocytes of patients with warts
Authors: M. G. BERNENGO, A. MATTEIS, M. MEREGALLI, G. CAPELLA, G. ZINA
Journal: British Journal of Dermatology (1980)

T and B lymphocyte populations were evaluated in forty-one patients with multiple recurring warts. Active rosettes (T-Ea) and total T lymphocytes (T-Et) were significantly decreased. The in vitro effect of a calf thymus extract (TP-I) on peripheral blood lymphocytes was evaluated in thirty-three patients. A statistically significant increase in E-rosette forming cells was observed in twenty-three patients (69%). Serum blocking factors were not found in the patients with a positive response to TP-I, which suggests the possibility of a thymic hormone deficiency. In the case of non-responders to TP-I, on the other hand, an anti-lymphocyte antibody capable of directly blocking the hormone receptors on the undifferentiated lymphocytes may be postulated.
Development of Gastric Ulcer as a Complication of Gastric Freezing
Authors: Sheldon A. Lisker, Leroy H. Stahlgren, Henry J. Tumen
Journal: New England Journal of Medicine (1964)

DURING the past two years "gastric freezing" has been widely used in the treatment of duodenal ulcer.1 2 3 Recent discussions have shown that the value of this form of therapy has not yet been clearly established.4 Gastric freezing, nevertheless, has been widely publicized and popularized, and may come to be used uncritically, without sufficient recognition of the risks of the procedure.In the following case gastric freezing for chronic duodenal ulcer led to the formation of a very large gastric ulcer, with confined perforation, for which subtotal gastric resection became necessary.Case ReportA 44-year-old woman was admitted to the Graduate . . .