tbuckley/cabot-search huggingface dataset:
The long-term safety and efficacy of cyclosporin in severe refractory atopic dermatitis: a comparison of two dosage regimens
Authors: I.M. ZONNEVELD, M.A. DE RIE, R.C. BELJAARDS, H.J. VAN DER RHEE, J. WUITE, J. ZEEGELAAR, J.D. BOS
Journal: British Journal of Dermatology (1996)

Journal Article The long‐term safety and efficacy of cyclosporin in severe refractory atopic dermatitis: a comparison of two dosage regimens Get access I.M. ZONNEVELD, I.M. ZONNEVELD Departments of Dermatology, Academic Medical Center, University of Amsterdam. Dr I.M.Zonneveld, Academic Medical Center, University of Amsterdam, Department of Dermatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Search for other works by this author on: Oxford Academic Google Scholar M.A. DE RIE, M.A. DE RIE Departments of Dermatology, Academic Medical Center, University of Amsterdam. Search for other works by this author on: Oxford Academic Google Scholar R.C. BELJAARDS, R.C. BELJAARDS Kennemergasthuis, Haarlem, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar H.J. VAN DER RHEE, H.J. VAN DER RHEE Ziekenhuis Leyenburgh, Den Haag, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar J. WUITE, J. WUITE De Weverziekenhuis, Heerlen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar J. ZEEGELAAR, J. ZEEGELAAR de Lichtenberg, Amersfoort, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar J.D. BOS J.D. BOS Departments of Dermatology, Academic Medical Center, University of Amsterdam. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue s48, 1 September 1996, Pages 15–20, https://doi.org/10.1111/j.1365-2133.1996.tb00704.x Published: 01 September 1996
Internal cardiac defibrillation in man: pronounced improvement with sequential pulse delivery to two different lead orientations.
Authors: D L Jones, G J Klein, G M Guiraudon, A D Sharma, M J Kallok, J D Bourland, W A Tacker
Journal: Circulation (1986)

Wider applicability of an implantable automatic defibrillator depends on achieving internal cardiac defibrillation consistently with the lowest possible energy. In animal studies, we have found that the cardiac defibrillation threshold could be reduced when sequential shocks separated in time and spacially arranged were delivered to the heart. We compared internal cardiac defibrillation using a single pulse shock delivered through an intravascular catheter with this new method for internal cardiac defibrillation in patients undergoing cardiac surgery for the correction of arrhythmias. For the single pulse shock and the first pulse of the sequential pulse shock, current was passed through an intravascular catheter with the catheter cathode at the apex of the right ventricle and the anode at the superior vena cava-atrial junction region. The second pulse of the sequential pulse countershock was delivered between the catheter cathode in the right ventricular apex and an oval plaque electrode secured on the laterobasal left ventricular epicardium as anode. With the single pulse alone for shock delivery, 12 patients could be defibrillated with an average of 20.1 +/- 16.8 J, with a corresponding leading-edge peak voltage and current of 836 +/- 319 V and 9.4 +/- 4.5 A, respectively. However, two of the patients could not be defibrillated with energies below 50 J. With the sequential pulse shock delivery, a significant reduction in all values were recorded. Mean total energy for defibrillation averaged 7.7 +/- 6.0 J. Leading-edge peak voltage and current from the catheter averaged 430 +/- 148 V and 5.0 +/- 2.8 A, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
WHAT CAN THE MEDICAL PROFESSION DO FOR THE NAVY?
Authors: CHARLES F. STOKES
Journal: JAMA (1904)

The medical profession can do much for the Army by using its great influence to show that to serve the country and to protect the nation, and the individuals of the nation who go out to its defense, the Medical Department of the Army must be sufficiently and properly officered to give efficiency.More than this, as volunteers must be relied on, there should be in the country a number of reserve medical officers whose serv¬ ices can be available in time of need.A medical reserve has
Sudden cardiac death in athletes
Authors: C. Semsarian, J. Sweeting, M. J. Ackerman
Journal: BMJ (2015)

#### The bottom line

Sudden cardiac death is defined as an unexpected death, occurring usually within one hour from onset of symptoms in cases where the death is witnessed and in unwitnessed cases within 24 hours of the individual last being seen alive and well.1 Sudden cardiac death in athletes is the leading cause of medical death in this subgroup, with an estimated incidence of 1 in 50 000 to 1 in 80 000 athletes per year, although a wide range has been reported, from 1 in 3000 in some subpopulations to 1 in 1 000 000.2 Males, black or African Americans, and basketball players seem to be at a higher risk than other subgroups.2

#### Sources and selection criteria

We searched PubMed and the Cochrane Database of Systematic Reviews using the search terms “sudden cardiac death” and “athletes”. To ensure that we represented a diversity of opinion worldwide, particularly on preparticipation screening, …
Pyodermatitis-pyostomatitis vegetans and antibullous pemphigoid antigen 180 autoantibodies: a casual association?
Authors: L. Stingeni, M. Tramontana, G. Bassotti, L. Bianchi, P. Lisi
Journal: British Journal of Dermatology (2014)

Journal Article Pyodermatitis‐pyostomatitis vegetans and antibullous pemphigoid antigen 180 autoantibodies: a casual association? Get access L. Stingeni, L. Stingeni Section of Clinical, Allergological and Venereological Dermatology Department of Medicine University of Perugia Perugia 06156 Italy Search for other works by this author on: Oxford Academic Google Scholar M. Tramontana, M. Tramontana Section of Clinical, Allergological and Venereological Dermatology Department of Medicine University of Perugia Perugia 06156 Italy Search for other works by this author on: Oxford Academic Google Scholar G. Bassotti, G. Bassotti Section of Clinical, Allergological and Venereological Dermatology Department of Medicine University of Perugia Perugia 06156 Italy Search for other works by this author on: Oxford Academic Google Scholar L. Bianchi, L. Bianchi Section of Clinical, Allergological and Venereological Dermatology Department of Medicine University of Perugia Perugia 06156 Italy Correspondence: Leonardo Bianchi. E‐mail: leonardo.bianchi@unipg.it Search for other works by this author on: Oxford Academic Google Scholar P. Lisi P. Lisi Section of Clinical, Allergological and Venereological Dermatology Department of Medicine University of Perugia Perugia 06156 Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 3, 1 March 2015, Pages 811–813, https://doi.org/10.1111/bjd.13297 Published: 01 March 2015
Apoptosis of Cardiac Myocytes During Cardiac Allograft Rejection
Authors: Matthias Szabolcs, Robert E. Michler, Xiaochun Yang, Walif Aji, Dilip Roy, Eleni Athan, Robert R. Sciacca, Oktavjian P. Minanov, Paul J. Cannon
Journal: Circulation (1996)

Background Apoptosis is a distinct form of programmed cell death characterized by activation of endonucleases that cleave nuclear DNA, condensation and fragmentation of nuclear chromatin, blebbing of intact membranes, and cell shrinkage and fragmentation. The mechanisms responsible are unclear, but nitric oxide (NO) generated by inducible NO synthase (iNOS) has been demonstrated to induce apoptosis in macrophages in vitro. This study investigated whether apoptosis occurs during cardiac allograft rejection and examined the relationship of apoptosis to iNOS expression. Methods and Results Heterotopic abdominal transplantation from Lewis to Wistar-Furth rats was used as a model of cardiac allograft rejection; Lewis-to-Lewis grafts served as controls. Apoptosis was identified by DNA ladders after electrophoresis on agarose gels and by in situ labeling of DNA fragments; cell types were determined by immunohistochemistry. The number of apoptotic cardiac myocytes increased sharply from day 3 (0.31/mm 2 ventricular tissue) to day 5 (1.27/mm 2 ) after transplantation. At day 5, allografts showed a significant increase ( P &lt;.01) in apoptotic cardiac myocytes, macrophages, and endothelial cells compared with syngeneic grafts. The expression of iNOS mRNA, protein, and enzyme activity paralleled in time and extent the apoptosis of cardiac myocytes. iNOS immunostaining of infiltrating macrophages and cardiac muscle fibers increased significantly in the allografts at days 3 to 5 and was accompanied by immunostaining of both cell types for nitrotyrosine, which is indicative of peroxynitrite formation. Conclusions Apoptosis of myocardial cells occurs during cardiac allograft rejection. Apoptosis during rejection parallels the expression of iNOS, which suggests that apoptosis may be triggered by NO and peroxynitrite.
Evidence based health policy report: Screening for genital chlamydial infection
Authors: J. Pimenta
Journal: BMJ (2000)

Sexual and reproductive health in the United Kingdom urgently needs improving,1 and the government is developing the first integrated national strategy on sexual health. 2 3 Theoretical models describing the main determinants of the incidence of sexually transmitted infections suggest that reducing the mean duration of infectiousness is likely to lead to substantially lower levels of disease.4 One way of achieving such reductions is by the earlier ascertainment of cases through screening for infection. The chief medical officer's expert advisory group on Chlamydia trachomatis has recently evaluated the evidence for chlamydia screening in the United Kingdom.5 In this report we summarise the main evidence addressed by the group and outline how its conclusions have been implemented through a screening pilot in two health authorities in England.

#### Summary points

Chlamydia trachomatis is the most common curable, bacterial, sexually transmitted disease in the United Kingdom

Detection outside genitourinary clinics is limited because the infection is largely asymptomatic

If untreated, infection can lead to severe reproductive morbidity in women

Screening programmes have produced a reduction in prevalence of infection and pelvic inflammatory disease

A pilot of opportunistic screening in England is described targeting mainly young women in primary and secondary healthcare settings

C trachomatis infection is the most common curable, bacterial, sexually transmitted infection in England.6 Since 1988, the number of cases seen in genitourinary medicine clinics in England has risen by 46% from 30 349 to 44 196 in 1998. The greatest rise over the past 10 years has been in the younger sexually active population (16-19 year old women and 20–24 year old men), and rates of infection are currently highest in these groups.7 Chlamydial infection is largely asymptomatic and, if untreated, the long term consequences of pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility are especially …
STAT1 Negatively Regulates Basophil IL-4 Expression Induced by Respiratory Syncytial Vrus Infection
Authors: M.L. Moore, V.V. Parekh, L. Van Kaer, R.D. Collins, K. Goleniewska, M.H. Chi, D. Mitchell, J.E. Durbin, R.S. Peebles Jr.
Journal: Journal of Allergy and Clinical Immunology (2009)
Evidence for the Non-quasispecies Evolution of RNA Viruses
Authors: Gareth M. Jenkins, Michael Worobey, Christopher H. Woelk, Edward C. Holmes
Journal: Molecular Biology and Evolution (2001)

The quasispecies model of RNA virus evolution differs from those formulated in conventional population genetics in that neutral mutations do not lead to genetic drift of the population, and natural selection acts on the mutant distribution as a whole rather than on individual variants. By computer simulation, we show that this model could be inappropriate for many RNA viruses because the neutral sequence space may be too large to allow the formation of a quasispecies distribution. This view is supported by our analysis of gene sequences from vesicular stomatitis virus, which is considered a prototype RNA virus quasispecies. Our results are relevant to the evolution of RNA systems in general.
Methedrine in Surgical Operations
Authors: H. Dodd, F. Prescott
Journal: BMJ (1943)

MEDICALTIHURNAL 345 case no coils were overlying the stomach, the amount of intestine was greater, and there was the extreme gastrie dis- tension which would push the strangulated bowel towards the right lobe of the liver.The herniation itself presents interesting features which merit consideration-the opening in the lesser omentum and the accessory band of tissue between the gall-bladder and the duodenum.Prof. Blair has giver us his opinion of these.The aperture in the lesser omentum is not likely to be con- genital; it is more likely lto be " acquired."He has not seen such a -congenital defect, nor does he know of any develop- mental reason why it should occur.In the dissecting-room the lesser omentum is of so delicate a nature that one can imagine it would be readily torn by any hernia spreading within that part of the lesser sac.Indeed, in the anatomy room the lesser omentum is often torn through at the first attempt to pull down the stomach a little in order to explore the region between it and the liver.The band of tissue between the gall-bladder and the duodenum was an unusually well- developed example of the hepato-duodenal fold, which is not infrequently present to a lesser degree and represents a thinned- out part of the lower free border of the ventral mesentery of the fore-gut, which amounts to a prolongation, rather further to the right than usual, of the lesser omentum.The presence of this cystico-duodenal fold of membrane would produce a funnel-shaped approach to the foramen of Winslow and con- siderably assist an unusually mobile loop of bowel towards the foramen and into the lesser sac.This appears to us a considered and well-founded explanation of the appearances found post mortem.The appearance of the foramen at the necropsy led one to suspect that perhaps a loop of bowel had been herniated for some time.Such a condition has been described by Schwalbe (1904) in which strangulation did not occur.In comparison with herniae into the lesser sac, herniation into paraduodenal fossae is relatively common and the literature on such is now quite voluminous.Summary A fifth case of this unusual type of herniation is now described.Three abnormal features were present in the abdominal cavity: (I) a well-developed hepato-duodenal fold which had produced a funnel-shaped approach to the lesser sac; (2) a dilated foramen of Winslow; (3) an undue length of mesentery of the small bowel.We consider that the first and third factors, in association with the normal peristaltic movements, could produce a dilata- tionof the foramen and so give rise more readily to the herniation which had ruptured through the lesser omentum.It is a pleasure to us to express our gratitude to Prof.
Importance of Agonists in &amp;alpha;-Adrenoceptor Classification and Localisation of &amp;alpha;&lt;sub&gt;1&lt;/sub&gt;-Adrenoceptors in Human Prostate
Authors: J.C. McGrath, M.A. Naghadeh, J.D. Pediani, J.F. Mackenzie, C.J. Daly
Journal: European Urology (1999)
The Aims and Claims of the British Medical Temperance Association
Authors: J. J. Ridge
Journal: BMJ (1886)

1886k the middle line.It did not run in straight lines, but spread out ~o ¶ewhat lilke a coruscation of sheet lightning.It was over in a few *acods, Ibut quiivered a little, not being absolutely momentary.A*tei one explosion, another, and often a third or fourth, would fol- 1o4 in quick stuecessioni, and then he would be quite free for half an h'sr or an.lhour.The scalp was not in the least tender.The pain was quite bearTLble; in.fact, at first it rather amiused than hurt him; but, as the day went oIn, it becamie worse, and the explosions were at- te`dedb T a feelimo as if the left half of the head.werebelng suddenly OU,SilC(e1 In the evesiing, the explosions were, both more frequent aiYd'uorC p -olonged.On somnc occasions, thore was the suggestion of a4inpalsingr ilnto tle cheek and lower Jaw, invoRving, in fact, the *h`ole half of the head; bat, in these parts, its course could -not be t+kcea with1 accuracy.Neither in the upper nor in the lower jaw did it nhi alone the course of knownl nerve-truniks.The bicuspid tooth of the lower jaw wa.aching, a little all day; but it was a steady ache, atended with a feeling of general numb swelling about it, and witll teuderness on pressure, which prevented eating, but without any &plosious of severe pain.Mfy friend became very nervous in the e'ening, feeling sure that he was about to he the victim of "tic- doiuloureux."fouIld that, otl the previous day, he drank a bottle, of -claret in- stead of his usual niodicum of a third; that he had eaten much more liberally of meat than was his wont; and that, on the day on Which his neuralgia began, he also felt his anakles and wrists puffy and 9hirig; and, finally, that his urine begail oni that day to deposit uric acid' freely.Knowing that he had for long been threatened with gQut, I assured him that the neuralgia was gouty, and made him take a full dose of bicarbonate of potaslh at bedtime.On the next morn- in, 'both the toothache and the slheet-ligihItning pains inl the head had 6eVsed, and nothing romained but a very slight perception of general aRi. in that side of the head.4,A,lthoughl it is easy, in this instance, to feel confident as to the influ- ehpes which were at work, and to say that the.neuralgic shoots, and rob.ably the tooth-ache also, were caused by a gouty state of the blood lhsmia), yet it is more dificult to explain the local mechanism of tXepain.The scalp-pain always began in one and the same spot, Mjt1 that not onle to whieh any anatomical peculiarities attach.Was
Subclinical Maternal Rubella and Congenital Deafness
Authors: Collin S. Karmody
Journal: New England Journal of Medicine (1968)

At present 40 per cent of congenital deafness is inexplicable. The effect of rubella on the frequency of congenital deafness was studied five years after an epidemic of rubella in an island population. Of 87 congenially deaf children born in 1961, the year after the epidemic, 86 had deafness as the only demonstrable congenital abnormality. Only 20 gave a history of first-trimester rubella. By modern classification the remaining 67 cases should be labeled as idiopathic congenital deafness, all known causes for congenital deafness having been ruled out. Serologic tests for rubella antibodies on 30 of the idiopathic deaf children were positive in 74 per cent, as compared to 30 per cent in a control group born within the same year. This study suggests asymptomatic rubella infection in the first trimester as an etiologic factor in congenital deafness.
JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2
Authors: Yuki Kagoya, Akihide Yoshimi, Takako Tsuruta-Kishino, Shunya Arai, Takashi Satoh, Shizuo Akira, Mineo Kurokawa
Journal: Blood (2014)
Presence of human papillomavirus DNA and abnormal p53 protein accumulation in lung carcinoma.
Authors: Y. Soini, K. Nuorva, D. Kamel, R. Pollanen, K. Vahakangas, V. P. Lehto, P. Paakko
Journal: Thorax (1996)

BACKGROUND: In some carcinomas inactivation of the tumour suppressor gene product p53, either by point mutation or indirectly by the human papillomavirus (HPV), has been suggested as two alternative routes to malignant transformation. To test this hypothesis in lung tumours, 43 lung carcinomas were analysed by in situ hybridisation and polymerase chain reaction (PCR) for the presence of HPV DNA, and the results were compared with p53 protein immunohistochemical analysis. METHODS: The presence of HPV DNA in lung carcinoma was detected by nucleic acid in situ hybridisation for HPV types 6, 11, 16, 18, 31, and 33 using nonradioactively labelled DNA probes. Polymerase chain reaction (PCR) analysis was performed on all cases showing positive HPV DNA labelling by in situ hybridisation and in an additional 13 negative cases. Abnormal nuclear accumulation of the p53 protein was revealed by immunohistochemistry using the avidin-biotin-peroxidase complex method and a CM-1 polyclonal anti-human p53 antibody and a monoclonal mutation-specific Pab 240 p53 antibody. RESULTS: HPV DNA was found by in situ hybridisation in 13 lung carcinomas (30%). In all these cases subtype-specific HPV DNA could also be detected by PCR. Abnormal p53 protein accumulation was seen in 21 of the 43 carcinomas (49%), of which 18 were HPV negative. Twelve (57%) of the CM-1 positive cases were also positive for the mutation-specific antibody Pab 240. There was an obvious inverse relationship between the presence of papilloma viral DNA and abnormal p53 protein accumulation. CONCLUSIONS: p53 plays an important part in the development of lung carcinomas and, in some cases, HPV may contribute to it by binding and inactivating the p53 protein.
657 ANALYSIS OF THE RESPONSE TO PEGYLATED-INTERFERON PLUS RIBAVIRIN THERAPY IN CHRONIC HCV-1B INFECTION USING COMPREHENSIVE INFORMATION OF VIRAL AND HOST FACTORS
Authors: S. Maekawa, A. Kanayama, T. Omori, M. Miura, M. Kadokura, R. Sueki, K. Komase, H. Shindo, F. Amemiya, K. Shindo, T. Kitamura, T. Inoue, M. Sakamoto, S.-I. Okada, N. Enomto
Journal: Journal of Hepatology (2010)
Prophylaxis of Postoperative Pulmonary Atelectasis
Authors: C. M. Conway, J. M. Leigh
Journal: BMJ (1970)

safe and effective prophylactic," and because "50% of acute infarcts develop major ventricular dysrythmias."(4) Consider intravenous atropine for bradycardia.(5) If the pulse is irregular with runs of ectopic beats 50mg. of lignocaine slowly intravenously and the rest of the syringe pack intramuscularly.(6) Finally, beseech the ambulance men to give a smooth, steady, clammer-free ride to Treliske's coronary care unit.-I am, etc.,
Pure White-Cell Aplasia
Authors: Lee J. Levitt, Curt A. Ries, Peter L. Greenberg
Journal: New England Journal of Medicine (1983)

THE development of techniques for the in vitro clonogenic assay of hematopoietic progenitors1 has allowed investigation of clinical syndromes associated with immunologic injury to human stem cells.2 T-lymphocyte suppression of granulopoiesis has been described in patients with Felty's syndrome,3 and humoral inhibition of granulocyte-progenitor cells has been reported in patients with drug-associated agranulocytosis.4 Spontaneously arising (non-drug-associated) antibodies directed against human myeloid progenitors in patients with neutropenia have only recently been recognized.2 , 5 6 7 8 The antigenic and cellular specificity of these inhibitors, however, have not been well characterized, and the failure to demonstrate serum inhibitory activity against autologous granulocyte progenitors raises questions about . . .
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
Authors: Stephan Buch, Clemens Schafmayer, Henry Völzke, Christian Becker, Andre Franke, Huberta von Eller-Eberstein, Christian Kluck, Ingelore Bässmann, Mario Brosch, Frank Lammert, Juan Francisco Miquel, Flavio Nervi, Michael Wittig, Dieter Rosskopf, Birgit Timm, Christine Höll, Marcus Seeger, Abdou ElSharawy, Tim Lu, Jan Egberts, Fred Fändrich, Ulrich R Fölsch, Michael Krawczak, Stefan Schreiber, Peter Nürnberg, Jürgen Tepel, Jochen Hampe
Journal: Nature Genetics (2007)