tbuckley/cabot-search huggingface dataset:
Nonconvulsive Generalized Status Epilepticus and AIDS
Authors: Meng C. Wong, Nicholas D.A. Suite, Douglas R. Labar
Journal: Annals of Internal Medicine (1992)

Letters15 January 1992Nonconvulsive Generalized Status Epilepticus and AIDSMeng C. Wong, MRCP, Nicholas D.A. Suite, MD, Douglas R. Labar, MD, PhDMeng C. Wong, MRCP, Nicholas D.A. Suite, MD, Douglas R. Labar, MD, PhDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-2-171 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Nonconvulsive generalized status epilepticus (NCGSE) is characterized by slowness in behavior and mentation, confusion, and sometimes stupor, lasting for more than an hour and accompanied by generalized repetitive continuous or nearly continuous epileptiform activity on the electroencephalogram (EEG). NCGSE has been predominantly reported as an epileptic syndrome beginning in older adults and in children with petit mal epilepsy. We report a patient with the acquired immunodeficiency syndrome who had NCGSE.Our patient had a history ofPneumocystis cariniipneumonia and was hospitalized with pancreatitis. He improved markedly with treatment over 5 days. A baseline mildly abnormal mental...References1. NaviaPrice BR. The acquired immunodeficiency syndromedementia complex as the presenting or sole manifestation of human immunodeficiency virus infection. Arch Neurol. 1987;44:65-9. CrossrefMedlineGoogle Scholar2. HoltzmanKakuSo DDT. New-onset seizures associated with human immunodeficiency virus infection: causation and clinical features in 100 cases. Am J Med. 1989;87:173-7. CrossrefMedlineGoogle Scholar3. Labar D. Seizures in the acquired immunodeficiency syndrome. Recent Adv Neurol. 1991;5:[In press]. Google Scholar4. WongSuiteLabar MND. Seizures in human immunodeficiency virus disease. Arch Neurol. 1990;47:640-2. CrossrefMedlineGoogle Scholar5. PriceSidtisRosenblum RJM. The AIDS dementia complex: some current questions. Ann Neurol. 1988;23(Suppl):S27-33. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The New York Hospital/Cornell Medical Center New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNon-Convulsive Status Epilepticus in the Presence of Catatonia: A Clinically Focused ReviewThe uncommon causes of status epilepticus: A Systematic ReviewAIDS Aware 15 January 1992Volume 116, Issue 2Page: 171-172KeywordsAIDSBehaviorChildrenElderlyElectroencephalographyEpilepsyPancreatitisPneumocystis carinii pneumoniaStatus epilepticus Issue Published: 15 January 1992 PDF DownloadLoading ...
Abusive Debt Collection
Authors: Mike Mitka
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epithelial Changes in Anaemic East Africans
Authors: A. Jacobs
Journal: BMJ (1963)

Many patients suffering from severe iron-deficiency anaemia have symptoms and clinical signs related to the mouth, the pharynx, and the finger-nails.Soreness of the tongue with signs of atrophy are commonly found, and difficulty in swallowing localized to the post-cricoid region is felt by 10-20% of patients with iron deficiency.Koilonychia, when it occurs, appears to be associated with atrophy of the buccal mucosa (Jacobs, 1961).It is often assumed that the changes giving rise to these symptoms are due to the effect of
Sphingosine-1-phosphate receptor signalling in the heart
Authors: C. K. Means, J. H. Brown
Journal: Cardiovascular Research (2008)

The five known members of the sphingosine-1-phosphate (S1P) receptor family exhibit diverse tissue expression profiles and couple to distinct G-protein-mediated signalling pathways. S1P1, S1P2, and S1P3 receptors are all present in the heart, but the ratio of these subtypes differs for various cardiac cells. The goal of this review is to summarize data concerning which S1P receptor subtypes regulate cardiac physiology and pathophysiology, which G-proteins and signalling pathways they couple to, and in which cell types they are expressed. The available information is based on studies using a lamentably limited set of pharmacological agonists/antagonists, but is complemented by work with S1P receptor subtype-specific knockout mice and sphingosine kinase knockout mice. In cardiac myocytes, the S1P1 receptor subtype is the predominant subtype expressed, and the activation of this receptor inhibits cAMP formation and antagonizes adrenergic receptor-mediated contractility. The S1P3 receptor, while expressed at lower levels, mediates the bradycardic effect of S1P agonists. Studies using knockout mice indicate that S1P2 and S1P3 receptors play a major role in mediating cardioprotection from ischaemia/reperfusion injury in vivo. S1P receptors are also involved in remodelling, proliferation, and differentiation of cardiac fibroblasts, a cell type in which the S1P3 receptor predominates. Receptors for S1P are also present in endothelial and smooth muscle cells where they mediate peripheral vascular tone and endothelial responses, but the role of this regulatory system in the cardiac vasculature is unknown. Further understanding of the contributions of each cell and receptor subtype to cardiac function and pathophysiology should expedite consideration of the endogenous S1P signalling pathway as a therapeutic target for cardiovascular disease.
Fibrous Matrix of Ventricular Myocardium in Tricuspid Atresia Compared With Normal Heart
Authors: Siew Yen Ho, Mark Jackson, Lucienne Kilpatrick, Audrey Smith, Leon M. Gerlis
Journal: Circulation (1996)

Background The collagen matrix is a small component of the myocardium, but it provides a supportive framework. An increase in collagen in the pressure-overloaded ventricle is known to cause myocardial stiffness. However, little is known about the collagen matrix in the volume-overloaded ventricle, particularly in relation to congenital heart disease. Methods and Results We examined a total of 53 hearts with tricuspid atresia and 58 normal hearts matched for age. Using a microscopic-morphometric method, we analyzed the percentage per field area occupied by interstitial fibrous tissue in four sites in the ventricular mass for each specimen. A comparison of sampling sites showed no significant variations between normal and malformed hearts. Results from a homogeneity of regression coefficients analysis suggested that the two groups shared the same basic relation of proportion of fibrosis with age. The use of ANCOVA, however, revealed a clear separation between the extents of fibrous tissue in the two groups of hearts. Conclusions The myocardium of hearts with tricuspid atresia is consistently more fibrotic than normal heart and is probably an inherent part of the malformation. This difference could explain, at least in part, the clinical observation that the left ventricle is frequently abnormal, even at an early age.
Trends and outcomes of modern staging of solitary plasmacytoma of bone
Authors: Rahma Warsame, Morie A. Gertz, Martha Q. Lacy, Robert A. Kyle, Francis Buadi, David Dingli, Philip R. Greipp, Suzanne R. Hayman, Shaji K. Kumar, John A. Lust, Stephen J. Russell, Thomas E. Witzig, Joseph Mikhael, Nelson Leung, Steven R. Zeldenrust, S. Vincent Rajkumar, Angela Dispenzieri
Journal: American Journal of Hematology (2012)

Over the years, the definition of solitary plasmacytoma of bone (SPB) has shifted in part due to more modern testing capabilities. We hypothesized that outcomes data based on antiquated testing would not reflect outcomes using modern staging. To address both how widely applied adequate diagnostic staging is and what the progression rates of SPB as defined with state-of-the-art staging are, we performed a retrospective chart review of those patients with a diagnosis of SPB seen at our institution over the past decade. Two groups were studied: all patients with SPB (n = 127); and those patients referred to our institution for an indication other than progression (n = 91). The median PFS for those two groups were 26 months and 42 months, respectively. At baseline, only a minority of patients had state-of-the-art staging. The 5 patients with both modern imaging and a negative bone marrow had a 21 month PFS of 100%. Patients with plasmacytoma plus, one plasmacytoma but bone marrow consistent with monoclonal gammopathy of undetermined significance, fare worse than true SPB. The use of modern testing is imperative to characterize a patient's risk for progression. PET/CT plays an important role in the diagnostic work-up.
AUTORADIOGRAPHIC STUDIES ON THE IMMUNE RESPONSE
Authors: O. Mäkelä, G. J. V. Nossal
Journal: The Journal of Experimental Medicine (1962)

The DNA-synthesizing capacity of single antibody-forming cells was tested by a combination of micromanipulatory and autoradiographic techniques. Rats were immunized with S. adelaide flagellin, a protein antigen known to contain significant contamination with somatic (O) antigen. Single cells from secondarily immunized rats were tested for production of anti-H and anti-O antibodies by previously described and newer techniques. Positive antibody producers were transferred onto clean dry slides by micromanipulation, and autoradiographs were performed. When rats had received tritiated thymidine 1 hour before killing, labeling of antibody-forming cells was taken to imply that the cell was preparing for further mitotic division. It was found that on the 2nd and 3rd day of a secondary response, many of the antibody-producing cells in the nodes (chiefly plasmablasts) were incorporating tritiated thymidine. At the height of the cellular response, however, at 4 and 5 days, the majority of active antibody producers (chiefly mature plasma cells) were incapable of DNA synthesis. There appeared to be an inverse relationship between the antibody-forming and DNA-synthesizing capacities of the cell population under study; as more of the cells studied formed detectable antibody, fewer of them incorporated the DNA precursor. The age of plasma cells was also studied. Animals were killed at the height of the cellular immune response, having previously received an injection of tritiated thymidine 1 to 48 hours before killing; i.e., at 63 to 110 hours after their secondary stimulus. As the interval between isotope injection and killing increased, the proportion of antibody-forming cells showing labeling increased. With an interval of 30 hours, about half the antibody-forming cells were labeled and of 48 hours, over 95 per cent were labeled. This was taken as evidence that, few, if any, antibody-forming cells found at the height of a secondary response were more than 48 hours old. On the basis of these experiments and those reported in the accompanying paper, a simplified scheme showing the development of an antibody-forming clone in the secondary response was proposed.
Prediction of the site and severity of obstruction in hypertrophic cardiomyopathy by color flow mapping and continuous wave Doppler echocardiography
Authors: Ehud Schwammenthal, Michael Block, Bodo Schwartzkopff, Benno Lösse, Martin Borggrefe, Hagen Dietrich Schulte, Wolfgang Bircks, Günter Breithardt
Journal: Journal of the American College of Cardiology (1992)
Abstract 3049: Regulation of cancer cell stemness by delta-like 1 homolog (Drosophila) and prohibitins
Authors: Qun Lin, Asma Begum, Chenye Yu, Ming-Yeah Hu, Yuri Kim, Zhong Yun
Journal: Cancer Research (2014)

Abstract Cancer stem cell characteristics, especially their self-renewal and clonogenic potential, play an essential role in malignant progression and response to anti-cancer therapies. Currently, it remains largely unknown which pathways are involved in the regulation of cancer cell stemness and differentiation. Previously, we found that delta-like 1 homolog (Drosophila) or DLK1, a developmentally regulated gene, plays a critical role in regulation of differentiation, self-renewal, and tumorigenic growth of neuroblastoma cells. In order to gain mechanistic understanding of the involvement of DLK1 in intracellular signal transduction, we identified DLK1-interacting proteins using an affinity purification approach. As reported herein, we have found that DLK1 specifically interacts with the prohibitin (PHB) complex via the DLK1 cytoplasmic domain. PHB1 and the closely related PHB2 are encoded by evolutionarily conserved genes and possess diverse functions from mitochondrial structural integrity and oxidative phosphorylation to gene transcription in the nucleus. We have found that DLK1 regulates mitochondrial membrane potential and production of reactive oxygen species (ROS). Our data further reveal a role of PHBs and especially PHB2 in the regulation of cancer cell self-renewal as well as their clonogenic potential. Hence, the DLK1-PHB interaction constitutes a new signaling mechanism that promotes the maintenance of cancer cell stemness. This work was supported by a grant from the National Institutes of Health to ZY (R01CA125021). YK was supported in part by an institutional postdoctoral training grant (T32) from the National Institutes of Health and an Anna Fuller Fund Fellowship from Yale School of Medicine. Citation Format: Qun Lin, Asma Begum, Chenye Yu, Ming-Yeah Hu, Yuri Kim, Zhong Yun. Regulation of cancer cell stemness by delta-like 1 homolog (Drosophila) and prohibitins. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3049. doi:10.1158/1538-7445.AM2014-3049
Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease
Authors: Kathryn J. Martires, Kristin Baird, Seth M. Steinberg, Lana Grkovic, Galen O. Joe, Kirsten M. Williams, Sandra A. Mitchell, Manuel Datiles, Fran T. Hakim, Steven Z. Pavletic, Edward W. Cowen
Journal: Blood (2011)
Simplified Putti-Platt Procedure
Authors: George Truchly
Journal: JAMA (1962)

Twenty-six consecutive cases of recurrent dislocation of the shoulder joint were treated by a simplified operative technique. Detachment of the labrum and a defect in the posterolateral portion of the humeral head were the most frequent findings at the operation. The joint was closed by suturing the lateral stump and subscapularis muscle as one layer. of the capsule and subscapularis tendon as one layer to the periosteal tissues along the scapular neck and overlapping it with the medial portion of the capsule The average follow-up period was 3.7 years. There were no postoperative recurrences. Loss of external rotation averaged 20 degrees; abduction, 5 degrees. Preoperative activity was resumed, on the average, in 2 months. This procedure is advocated because of its relative simplicity, apparent reliability, and good functional results.
New atlas aims to show range of activity and quality in the NHS
Authors: J. Wise
Journal: BMJ (2010)

An atlas of variation in the NHS is to be published before the end of the year.

Muir Gray, chief knowledge officer of the NHS and director of the Oxford Centre for Healthcare Transformation, made the announcement at the Evidence 2010 conference in London this week.

“For the past 20 years cost effectiveness, quality, and safety have been the key words, but for the next 20 years value is going to be the key word,” Sir Muir told the conference, which was organised jointly by the BMJ Evidence Centre and the Centre for Evidence Based Medicine at the University of Oxford.

The atlas will be based on the …
Low-dose rivaroxaban reduced mortality in patients with a recent acute coronary syndrome
Authors: Richard G. Bach
Journal: Annals of Internal Medicine (2012)

ACP Journal Club15 May 2012Low-dose rivaroxaban reduced mortality in patients with a recent acute coronary syndromeRichard G. Bach, MDRichard G. Bach, MDWashington University School of Medicine, St. Louis, Missouri, USA (R.G.B.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-10-201205150-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationMega JL, Braunwald E, Wiviott SD, et al; ATLAS ACS 2–TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012;366:9-19. https://pubmed.ncbi.nlm.nih.gov/22077192Clinical Impact RatingsHospitalists: Cardiology: Reference1 Alexander JH, Lopes RD, James S, et al; APPRAISE-2 Investigators. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med. 2011;365:699-708. [PMID: 21780946] Google Scholar Author, Article, and Disclosure InformationAffiliations: Washington University School of Medicine, St. Louis, Missouri, USA (R.G.B.)This article was published at Annals.org on 1 May 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 2012Volume 156, Issue 10Page: JC5-3KeywordsAntiplatelet therapyCardiovascular therapyHemorrhageMyocardial infarctionReceptor antagonist therapyStroke ePublished: 15 May 2012 Issue Published: 15 May 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
OVULATION AND MENSTRUATION NOT INTERDEPENDENT FUNCTIONS.
Authors: C. C. THAYER
Journal: JAMA (1901)

From one of the most popular text-books<sup>1</sup>on midwifery in our medical colleges, I quote the following: "The intimate connection between ovulation and menstruation is now admitted by most physiologists, and it is held that the determining cause of the discharge is the periodic maturation of the Graafian follicles. and when the ovaries are removed by operation, menstruation does not take place." One of our latest physiologies, also popular as a text-book<sup>2</sup>in our medical colleges, states the following: "Women do not menstruate when both ovaries have been removed by operation. Some instances have been recently recorded, indeed, of a sanguineous discharge, occurring periodically from the vagina after both ovaries have been removed for disease; and it has been inferred from this that menstruation is a function independent from the ovaries, but this evidence is not conclusive." Most of us have been educated along the line of the
Cardiac Conduction Abnormalities in Myotonic Dystrophy.
Authors: Robert C. Griggs
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Cardiac Conduction Abnormalities in Myotonic Dystrophy.Robert C. Griggs, M.D., F.A.C.P., Robert J. Davis, M.D., David Anderson, M.D.Robert C. Griggs, M.D., F.A.C.P.Search for more papers by this author, Robert J. Davis, M.D.Search for more papers by this author, David Anderson, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-819_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHaving observed the sudden appearance of complete heart block in three patients with myotonic dystrophy, we prospectively studied cardiac conduction in other patients with the disorder. Routine electrocardiography in 23 adults with myotonic dystrophy showed first-degree A-V block (second-degree heart block) in 14 and right bundle-branch block in 1. In seven patients the ECG abnormality was noted during family screening before the clinical diagnosis was made. Eight patients with first-degree heart block underwent His-bundle electrocardiography to define more accurately the site of conduction abnormalities. Conduction time through the A-V node was prolonged in one patient, whereas all eight patients had... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert C. Griggs, M.D., F.A.C.P.; Robert J. Davis, M.D.; David Anderson, M.D.Affiliations: Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMyotonic Muscular Dystrophy 1 May 1973Volume 78, Issue 5Page: 819-820KeywordsElectrocardiographyHeartHeart diseasesMyotonic dystrophyRight bundle branch block ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
Safety and Side Effects of Sustained-Release Niacin
Authors: Murray Weiner
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The article by Dr McKenney and colleagues<sup>1</sup>and the editorial comments of Dr Lasagna<sup>2</sup>are important and useful, but do not support the authors' conclusion that SR formulations of nicotinic acid are more toxic than IR preparations. Clinical evaluation of relative toxicity requires a comparison of toxic manifestations at therapeutically equieffective doses rather than equal doses in milligrams. The data indicate that the hypocholesterolemic potency of the SR preparation is at least twice that of the IR formulation. Thus, the side effects of SR in doses of 1000 to 1500 mg daily should be compared with that of 2000 to 3000 mg of IR. The protocol called for sequential dose increases of both formulations regardless of cholesterol response. The clinical tolerance of SR is remarkably better. The liver function data should be compared at equieffective doses. Such analysis would probably show no significant toxicologic difference