Carcinoembryonic Antigen Elevation in Renal Failure
Authors: Robert D. Brandstetter, Vincent A. Graziano, Marcia J. Wade, Stuart D. Saal
Journal: Annals of Internal Medicine (1979)

Brief Reports1 December 1979Carcinoembryonic Antigen Elevation in Renal FailureROBERT D. BRANDSTETTER, M.D., VINCENT A. GRAZIANO, M.D., MARCIA J. WADE, M.D., STUART D. SAAL, M.D.ROBERT D. BRANDSTETTER, M.D.Search for more papers by this author, VINCENT A. GRAZIANO, M.D.Search for more papers by this author, MARCIA J. WADE, M.D.Search for more papers by this author, STUART D. SAAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-6-867 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCarcinoembryonic antigen was first described in 1965 by Gold and Freedman (1). They defined an antigen detected by heterologous antisera in extracts from colonic adenocarcinoma and the digestive-tract organs of human embryos and fetuses. The initial finding of elevated carcinoembryonic antigen levels in 97% of patients with colonic cancer suggested that it was an early sensitive tumor marker (2). Later studies showed a better correlation between elevation and metastatic disease than with early stages of colonic cancer (3), and elevated levels were subsequently reported in carcinoma of the breast, lung, prostate, and lymphoid tissue (4-6).The nonspecificity of carcinoembryonic antigen...References1. GOLD P and FREEDMAN S. Demonstration of tumor-specific antigens in human colonic carcinomata by immunologic tolerance and absorption techniques. J Exp Med. 1965;121:439-62. CrossrefMedlineGoogle Scholar2. THOMSON D, KRUPEY J, FREEDMAN S, and GOLD P. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci USA. 1969;64:161-7. CrossrefMedlineGoogle Scholar3. MOORE T, KUPCHIK H, MARCON N, and ZAMCHECK N. Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders. Am J Dig Dis. 1971;16:1-7. CrossrefMedlineGoogle Scholar4. HANSEN H, SNYDER J, and MILLER E. Carcinoembryonic antigen (CEA) assay: a laboratory adjunct in the diagnosis and management of cancer. Hum Pathol. 1974;5:139-47. CrossrefMedlineGoogle Scholar5. VINCENT R and CHU T. Carcinoembryonic antigen in patients with carcinoma of the lung. J Thorac Cardiovasc Surg. 1973;66:320-8. CrossrefMedlineGoogle Scholar6. LAURENCE D and NEVILLE A. Faetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review. Br J Cancer. 1972;26:335-55. CrossrefMedlineGoogle Scholar7. MOORE T, DHAR P, ZAMCHECK N, KEELEY A, GOTTLIEB L, and KUPCHIK H. Carcinoembryonic antigen(s) in liver disease: I. Clinical and morphological studies. Gastroenterology. 1972;63:88-94. CrossrefMedlineGoogle Scholar8. HANSEN H, LANCE K, and KRUPEY J. Demonstration of an ion sensitive antigenic site on carcinoembryonic antigen using zirconyl phosphate gel. Clin Res. 1971;19:143-8. Abstract. Google Scholar9. BRENNER B, HOSTETTER T, and HUMES H. Molecular basis for proteinuria of glomerular origin. N Engl J Med. 1978;298:826-33. CrossrefMedlineGoogle Scholar10. SLIFKIN R, GOLDBERG J, NEFF M, BAEZ A, MATTOO N, and GUPTA S. Malignancy in end-stage renal disease. Trans Am Soc Artif Intern Organs. 1977;23:34-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT D. BRANDSTETTER, M.D.; VINCENT A. GRAZIANO, M.D.; MARCIA J. WADE, M.D.; STUART D. SAAL, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySerum Tumor Markers in Hemodialysis PatientsEffect of haemodialysis on serum levels of tumour markers in patients with end-stage renal failureCancer Screening and Detection in Patients with End-Stage Renal DiseaseTumour Markers in Uraemia: Carbohydrate Antigen CA 72–4, Carcinoembryonic Antigen and Carbohydrate Antigen CA 19–9Tumor Markers in Patients with Chronic Renal FailureReoperation directed by carcinoembryonic antigen level: The importance of a thorough preoperative evaluationTumor markers: Value and limitations in the management of cancer patientsClinical Usefulness of Markers in Monitoring Patients with CancerHost Defenses and Immunologic Alterations Associated with Chronic HemodialysisSIMEON E. GOLDBLUM, M.D., WILLIAM P. REED, M.D. 1 December 1979Volume 91, Issue 6Page: 867-868KeywordsAdenocarcinomaAntigensCarcinoembryonic antigenEmbryosFetusesLung and intrathoracic tumorsLymphoid tissueProstate diseasesRenal failure ePublished: 1 December 2008 Issue Published: 1 December 1979 PDF downloadLoading ...