Laboratory Monitoring of High-Dose Factor VIIa Therapy
Authors: Maureane Hoffman
Journal: Annals of Internal Medicine (2003)

Letters4 November 2003Laboratory Monitoring of High-Dose Factor VIIa TherapyMaureane Hoffman, MD, PhDMaureane Hoffman, MD, PhDFrom Duke University Medical Center; Durham, NC 27705.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-9-200311040-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Recombinant factor VIIa (FVIIa) is approved as a bypassing agent to promote hemostasis in congenital or acquired hemophilia with inhibitors. Factor VIIa has also been used off-label in thrombocytopenia, platelet function defects, and liver transplantation and after trauma or surgery. Deveras and colleagues (1) examined the use of FVIIa to reverse excessive anticoagulation. The authors reported that the prothrombin time and international normalized ratio decreased after FVIIa therapy. In addition, bleeding patients stopped bleeding and nonbleeding patients did not bleed following invasive procedures. The juxtaposition of clinical efficacy with an improvement in the prothrombin time and international ...References1. Deveras RA, Kessler CM. Reversal of warfarin-induced excessive anticoagulation with recombinant human factor VIIa concentrate. Ann Intern Med. 2002;137:884-8. [PMID: 12458988] LinkGoogle Scholar2. Hoffman M, Monroe DM. The action of high-dose factor VIIa (FVIIa) in a cell-based model of hemostasis. Semin Hematol. 2001;38:6-9. [PMID: 11735103] CrossrefMedlineGoogle Scholar3. Monroe DM, Hoffman M, Oliver JA, Roberts HR. Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J Haematol. 1997;99:542-7. [PMID: 9401063] CrossrefMedlineGoogle Scholar4. Gerotziafas GT, Zervas K, Arzoglou P, Karavaggeli E, Parashou S, Van Dreden P, . On the mechanism of action of recombinant activated factor VII administered to patients with severe thrombocytopenia and life-threatening haemorrhage: focus on prothrombin activation. Br J Haematol. 2002;117:705-8. [PMID: 12028045] CrossrefMedlineGoogle Scholar5. Telgt DS, Macik BG, McCord DM, Monroe DM, Roberts HR. Mechanism by which recombinant factor VIIa shortens the aPTT: activation of factor X in the absence of tissue factor. Thromb Res. 1989;56:603-9. [PMID: 2626745] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Duke University Medical Center; Durham, NC 27705. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReversal of Warfarin-Induced Excessive Anticoagulation with Recombinant Human Factor VIIa Concentrate Ruby Anne E. Deveras and Craig M. Kessler Metrics Cited byRapid Reversal of Warfarin-Associated Hemorrhage in the Emergency Department by Prothrombin Complex ConcentratesProphylactic correction of the international normalized ratio in neurosurgery: a brief review of a brief literatureEffect of Recombinant Activated Factor VII in Critical Bleeding: Clinical Experience of a Single CenterFailure of recombinant factor VIIa to correct the coagulopathy in a case of severe postpartum hemorrhageWarfarin Reversal in Anticoagulant-Associated Intracerebral HemorrhageSuccessful management of intra-abdominal hemorrhage in the presence of severe alcoholic liver disease with activated recombinant factor VII (rFVIIa; NovoSeven): a case report and review of the literature on approved and off-label use of rFVIIaUse of recombinant factor VIIa prior to lumbar puncture in pediatric patients with acute leukemiaInfluence of warfarin therapy on activated factor VII clotting activityRecombinant activated factor VII and the anaesthetist.Recombinant Factor VIIa in the Treatment of Non-Hemophiliac BleedingUses of recombinant factor VIIa in traumaRecombinant Factor VIIa for Rapid Reversal of Warfarin Anticoagulation in Acute Intracranial Hemorrhage 4 November 2003Volume 139, Issue 9Page: 791KeywordsDrugsHemophiliaHemorrhageHemostasisInternational normalized ratioPlateletsProthrombin timeTherapeutic drug monitoringThrombinTrauma surgery ePublished: 4 November 2003 Issue Published: 4 November 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...