Glucocerebrosidase Treatment of Type I Gaucher Disease with Severe Pulmonary Involvement
Authors: Michael Pelini
Journal: Annals of Internal Medicine (1994)

Brief Communications1 August 1994Glucocerebrosidase Treatment of Type I Gaucher Disease with Severe Pulmonary InvolvementMichael Pelini, MD, Douglas Boice*, MD, Kevin O'Neil, MD, and James LaRocque, MDMichael Pelini, MDFrom the Naval Medical Center, Portsmouth, Virginia.Search for more papers by this author, Douglas Boice*, MDFrom the Naval Medical Center, Portsmouth, Virginia.Search for more papers by this author, Kevin O'Neil, MDFrom the Naval Medical Center, Portsmouth, Virginia.Search for more papers by this author, and James LaRocque, MDFrom the Naval Medical Center, Portsmouth, Virginia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-3-199408010-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Abstract*Deceased.References1. Zimran A, Kay A, Gelbart T, Garver P, Thurston D, Saven A, et al. Gaucher disease. Clinical, laboratory, radiologic, and genetic features of 53 patients. Medicine (Baltimore). 1992; 71:337-53. Google Scholar2. Lee R, Yousem S. The frequency and type of lung involvement in patients with Gaucher's disease (Abstract). Lab Invest. 1988; 58:54A. Google Scholar3. Schneider E, Epstein CJ, Kaback MJ, Brandes D. Severe pulmonary involvement in adult Gaucher's disease. Report of three cases and review of the literature. Am J Med. 1977; 63:475-80. Google Scholar4. Theise ND, Ursell PC. Pulmonary hypertension and Gaucher's disease: logical association or mere coincidence? Am J Pediatr Hematol Oncol. 1990; 12:74-6. Google Scholar5. Roberts WC, Fredrickson DS. Gaucher's disease of the lung causing severe pulmonary hypertension with associated acute recurrent pericarditis. Circulation. 1967; 35:783-9. Google Scholar6. Beutler E, Kay A, Saven A, Garver P, Thurston D, Dawson A, et al. Enzyme replacement therapy for Gaucher disease. Blood. 1991; 78:1183-9. Google Scholar7. Figueroa ML, Rosenbloom BE, Kay AC, Garver P, Thurston DW, Koziol JA, et al. A less costly regimen of alglucerase to treat Gaucher's disease. N Engl J Med. 1992; 327:1632-6. Google Scholar8. Barton NW, Brady RO, Dambrosia JM, Doppelt SH, Hill SC, Holder CA, et al. Dose-dependent responses to macrophage-targeted glucocerebrosidase in a child with Gaucher disease. J Pediatr. 1992; 120:277-80. Google Scholar9. Fallet S, Grace ME, Sibille A, Mendelson DS, Shapiro RS, Hermann G, et al. Enzyme augmentation in moderate to life-threatening Gaucher disease. Pediatr Res. 1992; 31:496-502. Google Scholar Author, Article, and Disclosure InformationAuthors: Michael Pelini, MD; Douglas Boice*, MD; Kevin O'Neil, MD; James LaRocque, MDAffiliations: From the Naval Medical Center, Portsmouth, Virginia.Corresponding Author: LCDR Kevin O'Neil, MC, Pulmonary Division, Ward 5A, Naval Medical Center, 620 John Paul Jones Circle, Portsmouth, VA 23708-5100.Disclaimer: The opinions expressed are those of the authors and do not represent those of the Navy or the Department of Defense. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPulmonary Manifestations of Endocrine and Metabolic Diseases in ChildrenRespiratory complications of metabolic disease in the paediatric population: A review of presentation, diagnosis and therapeutic optionsDelayed adverse vascular events after splenectomy in hereditary spherocytosisType I Gaucher disease with exophthalmos and pulmonary arteriovenous malformationThis page intentionally left blankBilateral lung transplant in Gauchers type-1 diseasePulmonary involvement in Type 1 Gaucher disease: functional and exercise findings in patients with and without clinical interstitial lung diseaseRemaining problems in the management of patients with Gaucher diseaseHepatopulmonary Syndrome in Gaucher Disease With Right-to-Left ShuntMetabolic DiseaseAlglucerase treatment of type 1 Gaucher disease with pulmonary involvement3 Gaucher's disease: clinical features and natural history8 Enzyme replacement therapy for Gaucher's disease12 A practical approach to diagnosis and management of Gaucher's diseasePediatric Pulmonary Gaucher Disease: Two Patterns of Lung InvolvementClinical and genetic studies of five fatal cases of Japanese Gaucher disease type 1Gaucher Disease 1 August 1994Volume 121, Issue 3 Page: 196-197 Keywords Capillaries Cells Dyspnea Enzymes Exercise Hypoxia Oxygen Pulmonary diseases Pulmonary hypertension Thorax ePublished: 15 August 2000 Issue Published: 1 August 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...