tbuckley/cabot-search huggingface dataset:
Fatal Superior Vena Cava Syndrome after Endoscopic Variceal Sclerotherapy
Authors: G. Kalambokis, P. Nikolopoulos, N. Tzambouras, M. Economou, E. Tsianos
Journal: Endoscopy (2006)

A 50-year-old woman with primary biliary cirrhosis (Child-Pugh class C) was admitted with esophageal variceal bleeding, and emergency endoscopic variceal sclerotherapy (EVS) with 16 ml of 5 % ethanolamine oleate was carried out. She had experienced two episodes of variceal bleeding during the previous 6 months and had been treated with emergency EVS, followed by weekly elective sessions, receiving a total of 90 ml of ethanolamine oleate. Four days after the last EVS session, the patient developed marked edema in the right arm. Chest computed tomography and cardiac ultrasonography were normal. Contrast venography revealed partial obstructions of the right brachiocephalic and right subclavian veins (Figure [1]). She progressively developed neck and face edema, jugular congestion, and dilated veins in the head and anterior chest wall, indicating the development of superior vena cava syndrome. There was no evidence of infection, and a central venous catheter had not been placed. The portal venous system was patent on Doppler ultrasonography. Acquired and inherited thrombophilic factors were excluded. Steroids failed to bring about clinical improvement, and the patient died a few days later.
Metatranscriptomics of the human gut microbiome
Authors: Thomas Sichertz Pontén
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
UK health department criticised for secret deal
Authors: Roger Dobson
Journal: BMJ (2007)

A £12m (€18m; $24m) joint venture involving the Department of Health and Dr Foster, a private company specialising in health information, was not subject to formal competitive tendering and could be open to legal challenge, a report from the National Audit Office said this week. 

Edward Leigh, chairman of the House of Commons committee of public accounts, who described it as a “hole and corner deal,” said the department may have paid some £4m more than its share was worth. 

The report says that the department is unable to show that setting up Dr Foster Intelligence represents good value for money. Dr Foster Intelligence is a joint venture with Dr Foster LLP, a holding company set up by the shareholders of Dr Foster Ltd. 

“This is primarily because they did not go out to tender to encourage fair competition,” …
Balancing Access and Evaluation in the Approval of New Cancer Drugs
Authors: Franklin G. Miller
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Mite Antigen, Der P1, Activates Dendritic Cells (DCs) and Stimulates Th2 Polarization through a Toll-like Receptor (TLR)-4 Pathway
Authors: S DAVE, J YOON, K WADA, T KOBAYASHI, M NASERI, H KITA
Journal: Journal of Allergy and Clinical Immunology (2008)
Future therapeutic options in food allergy
Authors: P. A. Eigenmann
Journal: Allergy (2003)

Up to 5% of young children and 2% of adults suffer from food allergy. Among them many have immunoglobulin E (IgE)‐mediated food allergy, a condition with potentially fatal allergic reactions. Several studies have addressed possible definite treatment options for food allergy. Immunotherapy, by the oral route or by systemic injections shows promising preliminary results, but current interpretation of these therapeutic options are mostly handicapped by studies with insufficient scientific support, or by severe side‐effects. Currently, no studies can support pharmacotherapy. Finally, most promising results were recently published with anti‐IgE antibodies in a human trial, or various approaches in a mouse model of food allergy (chinese herbal medicine, specific modulation of the T cell response). Rapidly evolving findings might provide hope for a cure of food allergy in the near future.
Adrenergic control of a constitutively active acetylcholine-regulated potassium current in canine atrial cardiomyocytes
Authors: Y YEH, J EHRLICH, X QI, T HEBERT, D CHARTIER, S NATTEL
Journal: Cardiovascular Research (2007)

Canine atrial cardiomyocytes display a constitutively active, acetylcholine-regulated, time-dependent K+ current (IKH) that contributes to atrial repolarization and atrial tachycardia-induced atrial-fibrillation promotion. Adrenergic stimulation favors atrial arrhythmogenesis but its effects on IKH are poorly understood.Adrenergic modulation of IKH was studied in isolated canine atrial cardiomyocytes with whole-cell patch-clamping, and action-potential consequences were assessed in multicellular preparations with fine-tipped microelectrodes. Isoproterenol increased IKH in a concentration-dependent manner (maximum 103+/-22% increase), an effect mimicked by forskolin and 8-bromo-cyclic AMP. Isoproterenol effects were prevented by propranolol and the selective beta1-adrenoceptor blocker CGP-20712A, but not the beta2-blocker ICI-118551. Isoproterenol enhancement was prevented by pipette-administered protein kinase A (PKA) inhibitor peptide or by superfusion of H89 (PKA blocker). Phenylephrine decreased IKH in a reversible, concentration-dependent way. This effect was blocked by the alpha-antagonist prazosin and the selective alpha1A-blocker niguldipine, but not the alpha1B-blocker chloroethylclonidine or the alpha1D inhibitor BMY-7378. Phenylephrine effects were prevented by the phospholipase C (PLC) inhibitor U73122 and the protein kinase C (PKC) inhibitor bisindolylmaleimide. The PKC-activating phorbol ester PDD (but not its inactive analogue alpha-PDD) mimicked phenylephrine effects. Action potential recordings in the presence and absence of the selective IKH blocker tertiapin indicated a functional role of alpha- and beta-adrenergic actions on IKH. Adrenergic regulation of cholinergic agonist-induced K+ current paralleled that of IKH.IKH is under dual regulation by the adrenergic system: beta1-adrenergic stimulation enhances IKH via cAMP-dependent PKA pathways, whereas alpha1A-adrenergic stimulation inhibits IKH via PLC-mediated PKC activation. Modulation of constitutive acetylcholine-regulated K+ current is a novel potential mechanism for adrenergic control of atrial repolarization.
Changes in climate and biota on geologic time scales
Authors: W.F. Ruddiman
Journal: Trends in Ecology & Evolution (1990)

The 1980s saw the emergence of a new approach that is both enhancing our understanding of climatic change on geologic time scales and providing insight into the impact of these climatic changes on the continental and marine biota. This approach (loosely termed 'data-model comparisons') has been applied both to glacial-interglacial changes occurring during the last three million years and driven by variations in the earth's orbit around the sun, and to the slower climatic changes occurring over much longer time scales and driven by tectonic processes. The strength of this approach lies in comparing the results of two independent ways of studying the climate system, and thus providing insight into the strengths and weaknesses of each. Comparisons are made between climatic changes simulated by experiments with General Circulation Models and those reconstructed from fossils. Close agreement between the results of these two independent techniques implies that the key physical processes acting within the climate system have been identified; fundamental mismatches motivate re-examination of both the models and the fossil biotic data.
A safe and simple method for removal and replacement of a percutaneous endoscopic gastrostomy tube after “buried bumper syndrome”
Authors: M. Binnebösel, C. Klink, J. Otto, V. Schumpelick, S. Truong
Journal: Endoscopy (2010)

Percutaneous endoscopic gastrostomy (PEG) tubes are preferred for long-term enteral nutrition. A rare complication of using PEG is the “buried bumper syndrome” (BBS) ([Fig. 1]). Various techniques have been described to remove the PEG tube in such situations, but they mostly require advanced endoscopic skills and are unsuccessful in most cases [1] [2] [3] [4] [5]. We have designed a novel endoscopic technique that does not require using a needle and a knife or complex endoscopic manipulation.
Effect of Inhaled Steroids on the Course of Asthma
Authors: Constance P. van Schayck
Journal: Annals of Internal Medicine (1993)

Letters15 November 1993Effect of Inhaled Steroids on the Course of AsthmaConstance P. van Schayck, MD, Edward Dompeling, MD, and Hans Folgering, MDConstance P. van Schayck, MDSearch for more papers by this author, Edward Dompeling, MDSearch for more papers by this author, and Hans Folgering, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-10-199311150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:To determine whether inhaled corticosteroid treatment prevents the accelerated decline in FEV1 observed during bronchodilator therapy alone, patients must be observed during a prolonged bronchodilator treatment period with and without inhaled steroids. This was not done in the study by Kerstjens and colleagues [1], a randomized, controlled trial of bronchodilator therapy with or without inhaled corticosteroids. Kerstjens and associates reported that patients who used only the 2-agonist had an FEV1 decline of 64 mL per year and that the patients who used the combination of the 2-agonist and the inhaled steroid had an FEV1 decline of 33 mL ...References1. Kerstjens HA, Brand PLP, Hughes MD, Robinson NJ, Postma DS, Sluiter HL, et al. A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease. N Engl J Med. 1992; 327:1413-9. Google Scholar2. Burrows B, Bloom JW, Traver GA, Cline MG. The course and prognosis of different forms of chronic airways obstruction in a sample from the general population. N Engl J Med. 1987; 317:1309-14. Google Scholar3. Dompeling E, van Schayck CP, van Grunsven P, van Herwaarden CL, Akkersmans R, Molema J, et al. Slowing the deterioration of asthma and chronic obstructive pulmonary disease observed during bronchodilator therapy by adding inhaled corticosteroids. Ann Intern Med. 1993; 118:770-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1993Volume 119, Issue 10Page: 1051-1052KeywordsAsthmaBronchodilatorsCorticosteroid therapyExtrapolationForced expiratory volume in the first second of expirationLungsMortalityRespiratory system proceduresSteroids ePublished: 15 August 2000 Issue Published: 15 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
937 AUTOIMMUNE-LIKE HEPATITIS FOLLOWING ALLOGENIC BONE MARROW TRANSPLANTATION: A NEW ENTITY CHARACTERISED BY USING A PROTEOMIC APPROACH
Authors: E. Beleoken, R. Sobesky, J.-P. Le Caer, B. Roche, M.Z. Mustapha, C. Guettier, M. Sebagh, C. Johanet, D. Samuel, J.-H. Bourhis, J.-C. Duclos-Vallee, E. Ballot
Journal: Journal of Hepatology (2012)
Do Canadian sport and exercise medicine physicans and emergency physicians give consistent sport-related concussion management advice?
Authors: James Carson, Laura Purcell, Bruce Davidson, Alisha Garel, Margaret Bell, Rahim Moineddin
Journal: British Journal of Sports Medicine (2013)

Objective To identify differences and gaps in the recommendations to patients for the management of sport-related concussion among sport and exercise medicine physicians and emergency physicians. Design A self-administered multiple-choice survey, which had been validated for content validity. Setting Canada. Subjects Physicians who have passed the diploma examination of the Canadian Academy of Sport and Exercise Medicine (CASEM-MDs) and physicians on the Canadian Association of Emergency Physicians (CAEP-MDs) database. Intervention The survey link was emailed to 470 CASEM-MDs and to 789 CAEP-MDs across Canada. Outcome Measures Key survey questions identified sources of concussion management information, usefulness of concussion diagnosis strategies, and whether physicians use common terminology when explaining cognitive rest strategies to patients after a sport-related concussion. Results Only 71% of CASEM-MDs usually use the SCAT2, whereas 86% of CAEP-MDs never use the SCAT2. 75% of CASEM-MDs usually advise time off of work or school after a sport-related concussion and 64% of CAEP-MDs do likewise. Only 75% of CASEM-MDs usually utilise balance testing. When queried how cognitive rest can best be achieved after a sport-related concussion, many choices were appealing with no consistent consensus. Conclusions We identified a lack of consistency in the implementation of recommendations for sport-related concussion patients. It appears that the SCAT2 is utilised more in the office setting than in the emergency department. More recent strategies such as balance testing have not gained consistent usage, even among physicians with recognised expertise in concussion management. Better knowledge translation efforts should target both of these groups of physicians. Acknowledgements Special thanks go to Paul Krueger, Leigh Hayden and the other 18 participants in the validation of our survey. Competing interests None.
Detachment of titanium and fluorohydroxyapatite particles in unloaded endosseous implants
Authors: D. Martini, M. Fini, M. Franchi, V.De Pasquale, B. Bacchelli, M. Gamberini, A. Tinti, P. Taddei, G. Giavaresi, V. Ottani, M. Raspanti, S. Guizzardi, A. Ruggeri
Journal: Biomaterials (2003)
Left Ventricular Fibromuscular Band Is Not a Specific Substrate for Idiopathic Left Ventricular Tachycardia
Authors: Fun-Chung Lin, Ming-Shien Wen, Chun-Chieh Wang, San-Jou Yeh, Delon Wu
Journal: Circulation (1996)

A fibromuscular band has been detected in patients with idiopathic left ventricular tachycardia, and this band has been suggested to be the anatomic substrate for the arrhythmia. Whether the fibromuscular band is a specific substrate for the tachycardia was systematically evaluated in a large group of consecutive patients with and without idiopathic left ventricular tachycardia.Conventional transthoracic two-dimensional echocardiography and multiplane transesophageal echocardiography were performed in 18 patients with idiopathic left ventricular tachycardia that was responsive to calcium blockers (group 1, tachycardia patients) and 40 patients with paroxysmal supraventricular tachycardia (group 2, control patients). There were 17 men and 1 woman, with a mean age of 29 +/- 11 years, in group 1 patients, and 21 men and 19 women, with a mean age of 42 +/- 12 years, in group 2 patients. The QRS morphology during tachycardia in group 1 patients displayed a pattern of right bundle-branch block with superior axis in 15 patients, indeterminate axis in 2 patients, and inferior axis in 1 patient. Radiofrequency ablation successfully eliminated the tachycardia in all 18 patients; the successful ablation site was located at the inferior apical septum in 11 patients, at the midseptum in 6 patients, and at the anterior lateral wall in 1 patient. Transthoracic echocardiography detected the fibromuscular band in 11 of the 18 patients, whereas multiplane transesophageal echocardiography detected the band in 17 of 18 patients. The fibromuscular band extended from the interventricular septum to the apex of the left ventricle. In group 2 patients, transthoracic echocardiography detected the fibromuscular band in 22 and multiplane transesophageal echocardiography detected the band in 35 of the 40 patients. The presence of a fibromuscular band in these two groups of patients was not statistically different.The presence of a left ventricular fibromuscular band is not a specific anatomic substrate for idiopathic left ventricular tachycardia.
Malignant myositis ossificans: occult gastric carcinoma presenting as an acute rheumatic disorder.
Authors: L H Rosenbaum, J J Nicholas, B S Slasky, D L Obley, L D Ellis
Journal: Annals of the Rheumatic Diseases (1984)

A patient developed ossifying skeletal muscle metastases from a primary gastric mucin-producing adenocarcinoma. The unusual nature of skeletal muscle metastases and the inflammatory-like syndrome associated with heterotopic ossification is reviewed. It is suggested that this case of 'neoplasm-induced post-traumatic myositis ossificans' may be caused by the interaction of local haemorrhage and thrombosis, mucin-producing tumour implants, and the presence of large quantities of gamma-carboxyglutamic acid, an amino acid associated with the calcification of bone matrix formation.
Investigations of methylmercury-induced alterations in neurogenesis.
Authors: Elaine M Faustman, Rafael A Ponce, Ying C Ou, Ma Aileen C Mendoza, Thomas Lewandowski, Terrance Kavanagh
Journal: Environmental Health Perspectives (2002)

Methylmercury (MeHg) has been an environmental concern to public health and regulatory agencies for over 50 years because of its toxicity to the human nervous system. Its association with nervous system toxicity in adults and infants near Minamata Bay, Japan, in the 1950s initiated environmental health research inquiries that continue to this day. Observations of greater neurotoxicity with gestational compared with adult exposure suggest a unique susceptibility of the developing nervous system to MeHg. Despite extensive research conducted over the last half century, determination of definitive molecular mechanisms underlying the observed neurotoxic effects of MeHg have not been identified. This paper summarizes results of a series of experiments conducted to examine the effects of MeHg on neuroepithelial cell proliferation, a hypothesized mode of action for its selective effects on neurogenesis. Observed effects of MeHg on cell cycle entry and progression were associated with alterations in a variety of cell cycle regulatory molecules, including p21 signaling pathways. We place these studies in the context of other cellular responses involved in signal transduction, including oxidative stress, altered protein phosphorylation, and altered intracellular calcium homeostasis. Although existing information suggests that no single mechanism underlies the diverse array of effects associated with MeHg-induced developmental neurotoxicity, we demonstrate characteristic effects of MeHg on cell signaling that contribute to observed effects on cell proliferation. Experimentally derived cell cycle kinetic and cytotoxicity data allowed development of a biologically based dose-response model of MeHg-induced alterations in neurodevelopment, which can form the basis for information synthesis and hypothesis testing and for use in assessing risks from environmental exposures.
Defibrillation by ambulance staff
Authors: M C Colquhoun, R S Job
Journal: BMJ (1989)

to 1) blockers as the sole agent to treat hypertension associated with diabetes mellitus in black patients.It has been emphasised that the use of angio- tensin converting enzyme inhibitors should be tempered with caution."This is especially so with captopril as the sole agent for treating hypertension associated with diabetic nephropathv in different ethnic groups.
New Editor Named at New England Journal
Authors: Marsha F. Goldsmith
Journal: JAMA (1991)

THE NEW editor-in-chief of<i>The New England Journal of Medicine (NEJM)</i>is Jerome P. Kassirer, MD, an internist and nephrologist. Kassirer, who is the Sara Murray Jordan Professor of Medicine and Vice Chair of the Department of Medicine at Tufts University School of Medicine, and Associate Physician-in-Chief at the New England Medical Center, both in Boston, Mass, will assume his new position in July. He is the 38th person to head the journal since its start in 1812, succeeding Arnold S. Relman, MD, who announced his retirement last July after 14 years as editor. In addition to being an honored educator—he received the 1989 Alpha Omega Alpha Distinguished Clinical Science Teacher Award at Tufts—the 58-year-old Kassirer has published extensively. He is editor-in-chief of<i>Cur-</i><i>rent Therapy in Internal Medicine</i>(3rd edition), coeditor of<i>Clinical Problem Solving</i>, coeditor of the<i>Nephrology Fo-. rum</i>, and a former<i>NEJM</i>editorial board member. He