tbuckley/cabot-search huggingface dataset:
Peripheral blood mononuclear leukocyte cyclic adenosine monophosphate specific phosphodiesterase activity in childhood atopic dermatitis
Authors: I.H. COULSON, S.N. DUNCAN, C.A. HOLDEN
Journal: British Journal of Dermatology (1989)

Significantly elevated activity of peripheral blood mononuclear cell cAMP specific phosphodiesterase (PDE) activity has been previously reported in adults with atopic dermatitis and in the cord blood of children born to atopic parents. We have been unable to confirm such a significant elevation in children with atopic dermatitis, and we have not found any correlation with dermatitis severity, age or total serum IgE.
INDIVIDUAL REACTIONS TO COMMUNITY DISASTER
Authors: J. S. TYHURST
Journal: American Journal of Psychiatry (1951)

1. Psychiatric phenomena with respect to individual behavior under stress can be considered to lie along 4 main axes—the natural history of the process, reactions and factors at various stages of the process, and the psychodynamics of the interrelationships between reactions and factors in the continuum. 2. The natural history of individual behavior in acute community disasters that have been studied has been briefly described. This appears to fall into 3 overlapping phases—a period of impact, a period of recoil, and a posttraumatic period—each of which can be characterized according to stress, time, and psychological phenomena. 3. The relevance of the natural history method for this particular investigation and for psychiatric research in general has been briefly discussed.
PHLYCTENULAR OPHTHALMIA.Read in the Section on Ophthalmology at the Forty-Fourth Annual Meeting of the American Medical Association.
Authors: DUDLEY S. REYNOLDS
Journal: JAMA (1893)

Phlyctenular ophthalmia has been so variously described by writers and teachers it would seem but fair to assume that each may have been faithful in describing that form most frequently observed in his practice. Believing no form of phlyctenular ophthalmia should be regarded as a merely local form of disease, calling for local treatment alone, I am led to introduce the subject in its clinical aspects. It is certain the herpetic disease described by Stellwag is just as much a local manifestation of constitutional dyscrasia as are the serpiginous ulcers, or the more common conoidal masses of lymphoid cells described by the old writers as scrofulous and syphilitic ophthalmia. It is very important to distinguish between the phlyctenular diseases of miasmatic and malarious localities, and those observed in strumous, rachitic and syphilitic subjects. According to some writers it would be difficult to determine the syphilitic from the non-syphilitic cases; but
Tumor Growth Control with IDO-Silencing <i>Salmonella</i>—Letter
Authors: Robert M. Hoffman
Journal: Cancer Research (2013)

Blache and colleagues ([1][1]) state “Although previous studies in mice have observed modest tumor control with administration of attenuated Salmonella typhimurium ( S. typhimurium ) alone, it has proven to be less effective in more aggressive tumor models. Moreover, in clinical trials using the S
Peak flow may be useful in screening for COPD in the absence of spirometry
Authors: A Bhowmik
Journal: Thorax (2003)

▴ Jackson H, Hubbard R. Detecting chronic obstructive pulmonary disease using peak flow rate: cross sectional survey. BMJ2003;327:653–4 [OpenUrl][1][FREE Full Text][2] This short paper analysed data from the third National Health and Nutrition Survey (NHANES III). A total of 3874 subjects aged 50–90 years were included and their percentage predicted forced expiratory volume in 1 second (FEV1), FEV1/FVC ratio, peak flow rate (PEF), … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DJackson%26rft.auinit1%253DH.%26rft.volume%253D327%26rft.issue%253D7416%26rft.spage%253D653%26rft.epage%253D654%26rft.atitle%253DDetecting%2Bchronic%2Bobstructive%2Bpulmonary%2Bdisease%2Busing%2Bpeak%2Bflow%2Brate%253A%2Bcross%2Bsectional%2Bsurvey%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmj.327.7416.653%26rft_id%253Dinfo%253Apmid%252F14500437%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=FULL&journalCode=bmj&resid=327/7416/653&atom=%2Fthoraxjnl%2F58%2F12%2F1057.1.atom
Sudden Death and Hepatic Fatty Metamorphosis
Authors: Brad Randall
Journal: JAMA (1980)

There is a generally unrecognized epidemic of sudden, nonviolent deaths among alcohol abusers, largely due to fatty liver--related sudden deaths (FLDs). Using data from the North Carolina Office of the Chief Medical Examiner, 411 cases of FLD were identified from 1972 through 1976. The 411 FLD deaths, in view of a low autopsy rate among nonviolent alcohol abuser deaths and the lack of awareness of FLD, suggest a FLD death rate of epidemic proportions. The FLD population characteristics mirror those of the underlying alcohol-abusing population. The increased incidence of low-level (1 to 50 mg/dL) blood ethanol levels among FLD as compared with "control" groups is consistent with several theories linking FLD to some form of acute or hyperacute ethanol withdrawal phenomenon.
Nomifensine, Acute Hemolytic Anemia, and Renal Failure
Authors: RONALD J. BLOOMFIELD
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 November 1986Nomifensine, Acute Hemolytic Anemia, and Renal FailureRONALD J. BLOOMFIELD, M.D., IAN J. WILSON, M.B., Ch.B.RONALD J. BLOOMFIELD, M.D.Search for more papers by this author, IAN J. WILSON, M.B., Ch.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-5-807_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nomifensine (Merital, Hoechst-Roussel, Somerville, New Jersey), a non-tricyclic antidepressant, was withdrawn from the worldwide market (1) in January 1986 after reports from Europe of serious and occasionally fatal hypersensitivity reactions, notably hemolytic anemia. The following case report appears to document the worst reaction to nomifensine in the United States. It supports previous reports suggesting an association between nomifensine and acute hemolytic anemia with subsequent acute renal failure.A 32-year-old white female nurse took nomifensine for several months in 1985 for depression, with no complications. Later, against advice, she took one 50-mg capsule and within a few hours...References1. Nomifensine withdrawn by manufacturer. FDA Drug Bull. 1986;1:7-8. Google Scholar2. SALAMA A and MUELLER-ECKHARDT C. The role of metabolite-specific antibodies in nomifensine-dependent immune hemolytic anemia. N Engl J Med. 1985;313:469-74. CrossrefMedlineGoogle Scholar3. SALAMA A, MUELLER-ECKHARDT C, KISSEL K, PRALLE H, and SEEGER W. Ex vivo antigen preparation for the serological detection of drug-dependent antibodies in immune haemolytic anaemias. Br J Haematol. 1984;58:525-31. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RONALD J. BLOOMFIELD, M.D.; IAN J. WILSON, M.B., Ch.B.Affiliations: Mount Carmel Health Columbus, OH 43222 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1986Volume 105, Issue 5Page: 807-807KeywordsAcute renal failureHemolytic anemiaHypersensitivityNursesRenal failure ePublished: 1 December 2008 Issue Published: 1 November 1986 PDF downloadLoading ...
ACTION OF THE GOLDEN BELT DISTRICT MEDICAL SOCIETY OF KANSAS.
Authors: F. B. Browne
Journal: JAMA (1891)

At a regular meeting of the Golden Belt District Medical Society of Kansas, held at Topeka, Kansas, on April 9, 1891, Dr. William B. Dewees, of Salina, moved the following resolution which passed unanimously, viz.: Whereas, The Board of Trustees ofThe Journal of the American Medical Association, at a recent special session in Washington, D. C., adopted a resolution favoring the change of the home ofThe Journalfrom Chicago to Washington, and Whereas, This is a question which the Association will be called upon to answer at its next meeting at Washington, D. C., in May, 1891, and Whereas, We believe it to be for the best interests ofThe Journaland the Association, that the office and place of publication ofThe Journalshould not be removed. Therefore, be it <i>Resolved</i>, That the delegates from this Society to the next meeting of the American Medical Association are
Response of patients receiving high dose beclomethasone dipropionate
Authors: J. F. Costello, T. J. H. Clark
Journal: Thorax (1974)

<b>Costello, J. F. and Clark, T. J. H. (1974).</b><i>Thorax</i>, <b>29,</b> 571-573. <b>Response of patients receiving high dose beclomethasone dipropionate.</b> Beclomethasone dipropionate was inhaled by 16 patients with asthma in a dose of 1 mg daily for periods up to 24 weeks. No evidence of adrenal suppression was found in these patients as judged by basal cortisol levels. A further group of five patients with asthma inhaled 2 mg daily of beclomethasone dipropionate for periods up to 10 weeks and no evidence of adrenal suppression was found. A separate group of five patients was found to respond to increasing doses of beclomethasone dipropionate by increasing their forced expiratory volume in the first second. The results suggest that increased doses of beclomethasone dipropionate may provide additional benefit while continuing to avoid unwanted systemic side effects.
Prophylaxis of Atherosclerosis with Marine Omega-3 Fatty Acids
Authors: C von Schacky
Journal: Annals of Internal Medicine (1987)

Traditional approaches to prophylaxis of atherosclerosis have focused on one aspect of the pathogenesis of this multifactorial disease, such as platelet function or blood lipids, and therefore have had limited success. Epidemiologic studies show a striking inverse correlation of consumption of fish rich in the two omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, and mortality from cardiovascular disease. In studies of volunteers and patients, reductions in platelet responsiveness, lowering of blood lipids, and improvements of blood flow, as well as improvements in other values implicated in the pathogenesis of atherosclerosis, were induced with eicosapentaenoic and docosahexaenoic acids. These findings indicate that these omega-3 fatty acids have a larger prophylactic potential than traditional approaches. This potential must be scrutinized in meticulously designed and conducted trials with clinical endpoints.
The Significance of Poor Renal Transplant Concentrating Ability as Assessed by I-131 Hippuran Imaging
Authors: D Y KIM, R J BOUDREAU, R P DU CRET, C C KUNI
Journal: Clinical Nuclear Medicine (1988)

A pattern of very poor renal allograft concentration of I-131 Hippuran and good bladder activity has been observed by the authors. The kidneys are typically barely visualized and the renogram curve is flat. The significance of this particular finding has not been described in the literature. Accordingly, a retrospective review of all patients exhibiting this scan pattern was performed and the authors attempted to correlate it with clinical, laboratory, and pathological findings at the time of study. Of 11 patients exhibiting this scan pattern, three had very high urine outputs at the time of study. Of the remaining eight patients, five had chronic rejection. In the remaining three patients, the diagnosis was: one each, acute rejection, mixed acute and chronic rejection, and cyclosporine toxicity. The authors conclude that although this pattern is non-specific, if the patient is not in a high output state, it is usually related to chronic rejection.
DERMATITIS DUE TO INSECT POWDER
Authors: Marion B. Sulzberger
Journal: JAMA (1930)

This case is reported on account of certain features that seem of practical importance. <h3>REPORT OF CASE</h3> K. Q., an unmarried woman, aged 33, a housekeeper, noted a disorder of the skin which began on or about May 1, 1929, with several scratchlike marks on the dorsum of the right hand, and rapidly extended to the arms, neck, legs and body. The lesions consisted of vesicular, erythematous and papular eruptions. In some areas the papules and vesicles remained discrete; in others they coalesced to form weeping and denuded areas of varying sizes. Associated with these lesions of eczematous type were also urticarial wheals. The eruption was most severe on the hands, arms and upper parts of the body, and was extremely pruritic. The history and general examination elicited nothing pertinent beyond the following facts: The menses had ceased in April, 1929, with only a slight return of the menstrual flow
Idiopathic myositis: a rheumatological view.
Authors: M R Ehrenstein, M L Snaith, D A Isenberg
Journal: Annals of the Rheumatic Diseases (1992)

Twenty five patients with idiopathic myositis attended this department for long term follow up from 1980 to 1989. Twelve patients had primary polymyositis (four men, eight women) and six had primary dermatomyositis (three men, three women); five women had an overlap syndrome. Two patients had a malignant condition associated with the myositis. The mean age at diagnosis was 40 years. All of the patients had proximal muscle weakness, 18/25 had a raised creatine kinase value (mean 2325 IU/l), 19/20 had an abnormal electromyogram, and 19/24 had positive muscle biopsy samples. Of the disease specific antibodies, anti-Jo-1 was detected in only 1/21 patients tested (three patients with fibrosing alveolitis were negative for this antibody), but the 56 kDa antibody was detected in 12/17 patients. The HLA data analysed in the white patients (17/25) showed that 6/8 of those tested were HLA-DR3 positive. All patients were treated with prednisolone and azathioprine was used for 14/25 patients. Only three deaths occurred during the eight year follow up, but there was a substantial morbidity, which may reflect the referral pattern. Muscle strength tests and creatine kinase levels were useful in recording the response to treatment in some patients. These data emphasise that careful long term follow up of patients with myositis is mandatory and that although the present treatment strategy has substantially reduced the death rate, morbidity associated with the disease remains a major problem.
Anaerobes isolated from bone and joint infections and their susceptibility to antibiotics
Authors: Marina Illiaquer, Stéphane Corvec, Sophie Touchais, David Boutoille, Nathalie Asseray, Marie-Emmanuelle Juvin, Ghislaine le Gargasson, Alain Reynaud, Lise Crémet, Pascale Bémer
Journal: Journal of Infection (2012)
Urinary tract disease associated with chronic ketamine use
Authors: Angela M Cottrell, Rachel Athreeres, Pete Weinstock, Kate Warren, David Gillatt
Journal: BMJ (2008)

Regarding the case study by Dhillon et al,1 we have seen an alarming increase in people presenting to urological services in South West England with bladder symptoms associated with chronic ketamine use. Two case series in Hong Kong and Canada have been published, but ketamine associated bladder pathology has not been reported in the UK.2 3

Over the past two years, nine …
Protein Kinase CK2 Protects Multiple Myeloma Cells from ER Stress–Induced Apoptosis and from the Cytotoxic Effect of HSP90 Inhibition through Regulation of the Unfolded Protein Response
Authors: Sabrina Manni, Alessandra Brancalion, Laura Quotti Tubi, Anna Colpo, Laura Pavan, Anna Cabrelle, Elisa Ave, Fortunato Zaffino, Giovanni Di Maira, Maria Ruzzene, Fausto Adami, Renato Zambello, Maria Rita Pitari, Pierfrancesco Tassone, Lorenzo A. Pinna, Carmela Gurrieri, Gianpietro Semenzato, Francesco Piazza
Journal: Clinical Cancer Research (2012)

Abstract Purpose: Protein kinase CK2 promotes multiple myeloma cell growth by regulating critical signaling pathways. CK2 also modulates proper HSP90-dependent client protein folding and maturation by phosphorylating its co-chaperone CDC37. Because the endoplasmic reticulum (ER) stress/unfolded protein response (UPR) is central in myeloma pathogenesis, we tested the hypothesis that the CK2/CDC37/HSP90 axis could be involved in UPR in myeloma cells. Experimental Design: We analyzed CK2 activity upon ER stress, the effects of its inactivation on the UPR pathways and on ER stress–induced apoptosis. The consequences of CK2 plus HSP90 inhibition on myeloma cell growth in vitro and in vivo and CK2 regulation of HSP90-triggered UPR were determined. Results: CK2 partly localized to the ER and ER stress triggered its kinase activity. CK2 inhibition reduced the levels of the ER stress sensors IRE1α and BIP/GRP78, increased phosphorylation of PERK and EIF2α, and enhanced ER stress–induced apoptosis. Simultaneous inactivation of CK2 and HSP90 resulted in a synergic anti-myeloma effect (combination index = 0.291) and in much stronger alterations of the UPR pathways as compared with the single inhibition of the two molecules. Cytotoxicity from HSP90 and CK2 targeting was present in a myeloma microenvironment model, on plasma cells from patients with myeloma and in an in vivo mouse xenograft model. Mechanistically, CK2 inhibition led to a reduction of IRE1α/HSP90/CDC37 complexes in multiple myeloma cells. Conclusions: Our results place CK2 as a novel regulator of the ER stress/UPR cascades and HSP90 function in myeloma cells and offer the groundwork to design novel combination treatments for this disease. Clin Cancer Res; 18(7); 1888–900. ©2012 AACR.
Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma
Authors: Lijuan Chen, Siqing Wang, Yiming Zhou, Xiaosong Wu, Igor Entin, Joshua Epstein, Shmuel Yaccoby, Wei Xiong, Bart Barlogie, John D. Shaughnessy, Fenghuang Zhan
Journal: Blood (2009)
Radioimmunoassay of human fibrinopeptide B and kinetics of fibrinopeptide cleavage by different enzymes.
Authors: S B Bilezikian, H L Nossel, V P Butler, R E Canfield
Journal: Journal of Clinical Investigation (1975)

Thrombin converts fibrinogen to fibrin monomer by cleaving fibrinopeptides A and B (FPA and FPB) from the amino terminal ends of the A (alpha) and B (beta) chains. A radioimmunoassay capable of measuring the A peptide in human blood as an index of thrombin action in vivo has been described previously. This paper describes the development of a radioimmunoassay for FPB and the use of both assays in the demonstration of distinctive patterns of cleavage of the amino terminal ends of the A (alha) and B (beta) chains of fibrinogen by various enzymes. Antisera were raised in rabbits to a synthetic analogue of FPB coupled to bovine serum albumin. FPB analogue was couple to desaminotyrosine and radiolabeled with 125I by the chloramine-T technique. The radiolabeled peptide was bound by the antiserum, and binding was inhibited by synthetic or native FPB. Unbound tracer was separated from bound tracer by charcoal adsorption. The senistivity of the assay was such that 50% inhibition of binding of the tracer was caused by 1.25 ng of the native FPB. Fibrinogen was treated with thrombin, plasmin, trypsin, Reptilase, and an extract of the venom from Ancistrodon contortrix contortrix (ACC). After ethanol precipitation and centrifugation, dialysates of enzymatically altered fibrinogen were assayed for FPA and FPB. The action of thrombin on fibrinogen resulted in a rapid release of FPA and a slower release of FPB. Plasmin cleaved a segment(s) of the B (beta) chain which included FPB but cleaved no detectable FPA-containing material for the first 2 h of incubation. In the case of plasmin-treated fibrinogen, the dialysates had been further treated with thrombin before being assayed for FPA and FPB. Trypsin rapidly cleaved both peptides, the B before the A. Reptilase cleaved only FPA in 24 h. ACC cleaved FPB at a rapid rate, with a slowere cleavage of FPA. The distinctive cleavage patterns produced by the serine proteases may be useful in interpreting the levels of FPA and FPB measured in human blood and in studying the generation of FPA and FPB in clinical blood samples.
Detection of Pseudomembranous Colitis with lndium-111 Labeled Leukocyte Scintigraphy
Authors: DAVID L. BUSHNELL
Journal: Clinical Nuclear Medicine (1984)

Cytopathic effects of the Clostridium difficile toxin are responsible for the clinical and pathological manifestations of pseudomembranous colitis. The case presented here illustrates scintigraphic features associated with this entity when imaging with ln-111 labeled leukocytes. This condition should be considered in the differential diagnosis of patients with significant large bowel activity present on labeled leukocyte scintiscans.
Isolation and functional identification of a novel human hepatic growth factor: Hepatopoietin Cn
Authors: Chun-Ping Cui, Da-Jin Zhang, Bing-Xing Shi, Shao-Jun Du, Dan-Li Wu, Ping Wei, Gen-Shen Zhong, Zi-Kuan Guo, Yang Liu, Li-Sheng Wang, Chu-Tse Wu
Journal: Hepatology (2008)

Hepatic stimulating substance (HSS) was first isolated from weanling rat liver in 1975 and found to stimulate hepatic DNA synthesis both in vitro and in vivo. Since then, mammalian and human HSS have been investigated for their potential to treat hepatic diseases. However, the essential nature in composition and structure of HSS remain puzzling because HSS has not been completely purified. Heating, ethanol precipitation, and ion-exchange chromatographies had been carried out to isolate the protein with specific stimulating activity from newborn calf liver, and [(3)H]thymidine deoxyribose (TdR)/bromodeoxyuridine (BrdU) incorporation and carboxyfluorescein diacetate succinimidyl ester (CFSE)-based proliferation assay to determine the bioactivity in vitro and in vivo. We report the purification of a novel 30-kDa protein from a crude extract of calf liver HSS. This protein is a member of the leucine-rich acidic nuclear protein family (LANP) and has been named hepatopoietin Cn (HPPCn). Studies of partially hepatectomized (PH) mice show that levels of HPPCn messenger RNA (mRNA) increase after liver injury. Furthermore, the recombinant human protein (rhHPPCn) was shown to stimulate hepatic DNA synthesis and activate signaling pathways involved in hepatocyte proliferation in vitro and in vivo.HPPCn is a novel hepatic growth factor that plays a role in liver regeneration.