tbuckley/cabot-search huggingface dataset:
Intra-Aortic Balloon Pumping
Authors: KARL T. WEBER
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 September 1972Intra-Aortic Balloon PumpingKARL T. WEBER, M.D., JOSEPH S. JANICKI, M.S.KARL T. WEBER, M.D.Search for more papers by this author, JOSEPH S. JANICKI, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-3-477_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have read the editorial on intraaortic balloon pumping by Drs. Braunwald and Maroko (Ann Intern Med 76:659-661, 1972) . . . and believe that several additional issues deserve consideration.The principles of counterpulsation (an increase in coronary perfusion pressure and concomitant decrease in myocardial work requirements, reducing the metabolic demand-to-supply ratio) have a great many theoretical advantages for the effective treatment of ischemic heart disease, but the extent to which these effects are realized varies with each specific counterpulsation method. For instance, arterio-arterial counterpulsation, using an adjustable volume pump, has a greater ability to remove blood...References1. JACOBEY J, TAYLOR W, and SMITH G: A new therapeutic approach to acute coronary occlusion. II. Opening dormant coronary collateral channels by counterpulsation. Am J Cardiol 9:218-227, 1963 CrossrefGoogle Scholar2. WEBER K, JANICKI J, and WALKER A: Intraaortic balloon pumping: an analysis of several variables affecting balloon performance. Trans Am Soc Artif Intern Organs 18:in press, 1972 CrossrefMedlineGoogle Scholar3. SCHEIDT S: Physiologic effects of intraaortic balloon pumping in cardiogenic shock. Am J Cardiol 29:290, 1972 CrossrefGoogle Scholar4. GOLDFARB D, BROWN B, and CONTI C: Cardiovascular responses to diastolic augmentation in the intact canine circulation and after ligation of the anterior descending coronary artery. J Thorac Cardiovasc Surg 55:243-254, 1968 CrossrefMedlineGoogle Scholar5. WEIKEL A, JONES R, and DINSMORE R: Size limits and pumping effectiveness of intraaortic balloons. Ann Thorac Surg 12:45-53, 1971 CrossrefMedlineGoogle Scholar6. WEBER K, RATSHIN R, and RACKLEY C: Ventricular dysfunction following acute myocardial infarction (AMI) (abstract). Clin Res 20:403, 1972 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KARL T. WEBER, M.D.; JOSEPH S. JANICKI, M.S.Affiliations: Department of Medicine University of Alabama Medical Center Birmingham, Ala. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUtilization of Percutaneous Mechanical Circulatory Support Devices in Cardiogenic Shock Complicating Acute Myocardial Infarction and High-Risk Percutaneous Coronary Interventions 1 September 1972Volume 77, Issue 3 Page: 477-478 Keywords Blood volume Cardiovascular therapy Coronary heart disease ePublished: 1 December 2008 Issue Published: 1 September 1972 PDF downloadLoading ...
Influenza Vaccine: Split-Product versus Whole-Virus Types — How Do They Differ?
Authors: Peter A. Gross, Francis A. Ennis
Journal: New England Journal of Medicine (1977)

Although the swine-influenza-immunization campaign has been suspended for all but high-risk groups, it was attended by other problems besides the well publicized but very rare apparent association with Guillain-Barré syndrome. One of these other problems relates to the difference between split-product and whole-virus types of vaccines, a difference not generally appreciated by physicians. The problem is worth discussing because the basic principles apply to the manufacture of influenza vaccines other than the current swine-virus vaccine. Different manufacturing processes have been developed in the hope of minimizing reactivity (systemic type, fever, malaise, headache and myalgia; local type, arm pain, redness and . . .
Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome
Authors: N A Heerema, J Harbott, S Galimberti, B M Camitta, P S Gaynon, G Janka-Schaub, W Kamps, G Basso, C-H Pui, M Schrappe, M-F Auclerc, A J Carroll, V Conter, C J Harrison, J Pullen, S C Raimondi, S Richards, H Riehm, H N Sather, J J Shuster, L B Silverman, M G Valsecchi, M Aricò
Journal: Leukemia (2004)
Frequent, Phylogenetically Local Horizontal Transfer of the cox1 Group I Intron in Flowering Plant Mitochondria
Authors: M. V. Sanchez-Puerta, Y. Cho, J. P. Mower, A. J. Alverson, J. D. Palmer
Journal: Molecular Biology and Evolution (2008)

Horizontal gene transfer is surprisingly common among plant mitochondrial genomes. The first well-established case involves a homing group I intron in the mitochondrial cox1 gene shown to have been frequently acquired via horizontal transfer in angiosperms. Here, we report extensive additional sampling of angiosperms, including 85 newly sequenced introns from 30 families. Analysis of all available data leads us to conclude that, among the 640 angiosperms (from 212 families) whose cox1 intron status has been characterized thus far, the intron has been acquired via roughly 70 separate horizontal transfer events. We propose that the intron was originally seeded into angiosperms by a single transfer from fungi, with all subsequent inferred transfers occurring from one angiosperm to another. The pattern of angiosperm-to-angiosperm transfer is biased toward exchanges between plants belonging to the same family. Illegitimate pollination is proposed as one potential factor responsible for this pattern, given that aberrant, cross-species pollination is more likely between close relatives. Other potential factors include shared vectoring agents or common geographic locations. We report the first apparent cases of loss of the cox1 intron; losses are accompanied by retention of the exonic coconversion tract, which is located immediately downstream of the intron and which is a product of the intron's self-insertion mechanism. We discuss the many reasons why the cox1 intron is so frequently and detectably transferred, and rarely lost, and conclude that it should be regarded as the "canary in the coal mine" with respect to horizontal transfer in angiosperm mitochondria.
Corrigendum to “Prevention of Recurrent Urinary Tract Infections by Intravesical Administration of Hyaluronic Acid and Chondroitin Sulphate: A Placebo-Controlled Randomised Trial [Eur Urol 2011;59:645–51]
Authors: Rocco Damiano, Giuseppe Quarto, Ilaria Bava, Giuseppe Ucciero, Renato De Domenico, Michele I. Palumbo, Riccardo Autorino
Journal: European Urology (2011)
The Pharmacologic Principles of Medical Practice: A Textbook on Pharmacology and Therapeutics for Medical Students, Physicians, and the Members of the Professions Allied to Medicine
Authors: Joseph R. DiPalma
Journal: JAMA (1965)

<b>An Introduction to Pharmacology.</b>By J. J. Lewis. 3rd ed. 1,048 pp, with illus. $11.50. Williams &amp; Wilkins, 428 E Preston St, Baltimore 2, 1964 These books are reviewed together as both are on the same subject, and represent revised editions. And both of them, with single or dual authorship, contrast with the multi-authored texts edited by one or two people. The Krantz and Carr volume follows the format established in the first edition in 1949. Drugs are classified by their major therapeutic use under eight major headings such as autonomic nervous system and metabolism. This simplification makes the book a little difficult to use by those accustomed to the more-usual detailed classifications. The authors have retained the practice of including historical references and illustrations of famous contributors to pharmacology. On the whole, the present revision is fairly complete, although some sections have not been as extensively revised as others.
Oncolytic Vesicular Stomatitis Viruses Are Potent Agents for Intravesical Treatment of High-Risk Bladder Cancer
Authors: Boris A. Hadaschik, Kaixin Zhang, Alan I. So, Ladan Fazli, William Jia, John C. Bell, Martin E. Gleave, Paul S. Rennie
Journal: Cancer Research (2008)

Abstract Bladder cancer is the second most common genitourinary malignancy. At initial diagnosis, ∼70% of cases are non–muscle-invasive; however, current treatment options for superficial disease are of limited efficacy because many patients will develop recurrent tumors. The purpose of this study was to examine two replication-competent oncolytic vesicular stomatitis virus (VSV) strains as intravesical agents in an orthotopic murine model of high-grade bladder cancer. Four human bladder cancer cell lines (RT4, MGH-U3, UM-UC3, and KU-7) were treated with either wild-type VSV or a mutant Δ51M variant (AV3) in vitro. Both wild-type VSV and AV3, which has an impaired ability to shutdown innate immunity, preferentially killed the more aggressive, IFN-nonresponsive cell lines UM-UC3 and KU-7, whereas IFN-responsive RT4 and MGH-U3 cells were less susceptible. In vivo, KU-7-luc bladder tumor cells, which stably express firefly luciferase, were inoculated into nude mice by intravesical instillation and tumor growth was quantified using bioluminescence imaging. Mice with established xenografts were administered VSV intravesically on days 4, 9, and 14, and necropsy was performed after 3 weeks. AV3 as well as wild-type VSV significantly inhibited KU-7-luc tumor growth by 90% (AV3) and 98% (wild-type), respectively, as compared with controls treated with UV-inactivated VSV. Despite using immunocompromised hosts, there was no evidence of toxicity in either group. In conclusion, VSV instillation therapy showed promising antitumor activity and safety in an orthotopic model of bladder cancer. These findings provide preclinical proof-of-principle for the intravesical use of VSV against non–muscle-invasive bladder cancer, especially in IFN-refractory patients. [Cancer Res 2008;68(12):4506–10]
INTERRELATIONSHIPS OF SOME METABOLIC EFFECTS OF TESTOSTERONE PROPIONATE IN NORMAL MALES DURING RESTRICTED SODIUM INTAKE 12
Authors: E. Raymond Borun, Ernest Geiger, Lotta Dalberg
Journal: Journal of Clinical Investigation (1956)

Testosterone propionate (T.P.) has been used to stimulate protein anabolism in a variety of clinical conditions (1-5).Metabolic studies have repeatedly demonstrated that the hormone pro- duces nitrogen retention and an increase in body weight in normal subjects as well as in hypogonad individuals (1-6).However, there are discrepancies between the amount of weight gained and the amount of tissue synthesis calculated from the ni- trogen retention (1-4, 6).Usually the weight gain is greater than the calculated tissue synthesis but occasionally considerable nitrogen retention occurs without a parallel increase in body weight (7).The weight gain in excess of calculated tis- sue synthesis has been attributed to an accumula- tion of extracellular fluid secondary to sodium and chloride retention (1-3); in some instances reten- tion of these electrolytes is indeed sufficient to ac- count for the major portion of the weight gain as an isosmotic increment of extracellular fluid (1-3).Such observations suggest that the relationship between the change in body weight and nitrogen retention might be clarified if sodium and chloride retention were rigidly controlled.We therefore studied the metabolic effects of the hormone in normal adult males maintained on restricted so- dium and chloride intake.PROCEDURE Subjects and experimental plan: Six well-nourished normal young adult males (five medical students and one 1 Supported by a grant from the Los Angeles County Heart Association.2 Some of the data were previously published in Clin.
Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas
Authors: Yanwen Jiang, David Redmond, Kui Nie, Ken W Eng, Thomas Clozel, Peter Martin, Leonard HC Tan, Ari M Melnick, Wayne Tam, Olivier Elemento
Journal: Genome biology (2014)

Molecular mechanisms associated with frequent relapse of diffuse large B-cell lymphoma (DLBCL) are poorly defined. It is especially unclear how primary tumor clonal heterogeneity contributes to relapse. Here, we explore unique features of B-cell lymphomas - VDJ recombination and somatic hypermutation - to address this question.We performed high-throughput sequencing of rearranged VDJ junctions in 14 pairs of matched diagnosis-relapse tumors, among which 7 pairs were further characterized by exome sequencing. We identify two distinctive modes of clonal evolution of DLBCL relapse: an early-divergent mode in which clonally related diagnosis and relapse tumors diverged early and developed in parallel; and a late-divergent mode in which relapse tumors developed directly from diagnosis tumors with minor divergence. By examining mutation patterns in the context of phylogenetic information provided by VDJ junctions, we identified mutations in epigenetic modifiers such as KMT2D as potential early driving events in lymphomagenesis and immune escape alterations as relapse-associated events.Altogether, our study for the first time provides important evidence that DLBCL relapse may result from multiple, distinct tumor evolutionary mechanisms, providing rationale for therapies for each mechanism. Moreover, this study highlights the urgent need to understand the driving roles of epigenetic modifier mutations in lymphomagenesis, and immune surveillance factor genetic lesions in relapse.
Ischaemic brain damage of cerebral perfusion failure type after treatment of severe hypertension.
Authors: D I Graham
Journal: BMJ (1975)

obtained during the menstrual cycle,3 pregnancy,' and in cases of amenorrhoea with normal LH and FSH responses to synthetic gonadotrophin releasing hormone and with no pituitary tumour,3 indicating that prolactin secretion is stimulated by endogenous oestrogens.Exogenous oestrogens also stimulate prolactin secretion in women.5Thus oestrogens are an important factor in the control of prolactin secretion in humans.The decrease of serum prolactin levels with age in women and their rising trend with age in men is of practical value in interpreting the results of prolactin assays.
Primary HIV-1 Resistance
Authors: Roger J. Pomerantz
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Incidence and Clinical Features of Penetration in Peptic Ulceration
Authors: John R. Norris
Journal: JAMA (1961)

Penetration beyond the alimentary wall, characterized by dense fibrous adhesion or confined perforation, was found at operation in 139 of 350 peptic ulcers. The pancreas was the commonest site of penetration. This complication of peptic ulcer disease, often associated with medical intractability, is best recognized not in the laboratory but rather in the changing pattern of symptoms described by the patient.
Fractures, Dislocations and Sprains
Authors: Lawrence C. Parish
Journal: JAMA (1961)

A discussion of fractures well lends itself to the format of this carefully written and well-illustrated volume. The author has placed the illustrations on the left-hand page, and the accompanying text begins on the right. Although the author notes "the style is necessarily dogmatic and only the methods of treatment that I use myself are mentioned," he is being unduly harsh on himself. The roentgenograms and photographs of the more common fractures, dislocations, and sprains and their treatment are excellent and worthy of review by practicing physicians. The first sections of the book include histology of bones, classification of fractures, nomenclature used by the author, general treatment, some complications, and pathology. The main body of the book is divided into discussions on the upper limb, trunk, and lower limb.
Pseudo‐Gaucher cells in disseminated mycobacterial infection
Authors: Satya Vara Prasad Busarla, Feroz Allibhoy Sadruddin, Aliyah R. Sohani
Journal: American Journal of Hematology (2011)

The patient was a 27-year-old HIV-positive Kenyan woman (current CD4+ T-cell count of 80/mm3) admitted to the hospital with fever, hypotension, and acute abdominal pain. She was diagnosed with gastroenteritis and, upon further evaluation, was found to be pancytopenic. Her CBC results were as follows: RBC: 2.6 × 1012/L; hemoglobin: 6.9 g/dL; hematocrit: 20%; mean corpuscular volume: 78 fL; platelets: 35 × 109/L; WBC: 2.6 × 109/mm3 with the following differential: neutrophils: 77%, lymphocytes: 14%, monocytes: 7%, eosinophils: 0%, basophils: 2% 1. She was diagnosed with HIV infection 1 year prior, at which time her CD4+ T-cell count was 167/mm3 (reference range: 380–1080/mm3). At that time, she was started on antiretroviral therapy with lamivudine, tenofovir and nevirapine, and was also empirically started on anti-mycobacterial therapy with rifampin, isoniazid, ethambutol, and pyrazinamide. The patient self-discontinued the anti-mycobacterial therapy several months before admission. During the current admission, bone marrow trephine biopsy and aspiration were performed to evaluate her pancytopenia. Leishman stain showed decreased hematopoietic elements and scattered admixed macrophages with abundant striated cytoplasm (Pseudo-Gaucher cells) containing numerous negatively-stained bacilli (A). Bacilli were also present extracellularly (B) and were positive with Ziehl-Neelsen stain (B, inset), confirming the presence of mycobacteria. The bone marrow trephine biopsy demonstrated similar findings with aggregates of foamy macrophages replacing much of the hemopoietic marrow (C). Staining of paraffin sections showed intracellular bacilli positive for both Ziehl-Neelsen (not shown) and Periodic acid-Schiff (PAS) stains (D), consistent with atypical mycobacteria. No material was submitted for culture. The patient was restarted on anti-mycobacterial quadruple therapy, but expired on the 15th hospital day. Pancytopenia in this case was likely due to disseminated mycobacterial infection leading to extensive marrow replacement by histiocytes filled with acid-fast bacilli. The finding of pseudo-Gaucher histiocytes containing negatively-stained bacilli on air-dried Romanowsky-stained smears should lead to the suspicion of possible mycobacterial infection and further diagnostic work-up with special stains 1, 2. The large number of intracellular bacilli and their simultaneous positivity with both Ziehl-Neelsen and PAS stains on paraffin sections is characteristic of atypical mycobacteria 3.
Untoward effects associated with practolol: demonstration of antibody binding to epithelial tissue.
Authors: H E Amos, W D Brigden, R A McKerron
Journal: BMJ (1975)

An antibody which sticks to the intercellular region of xenogenic epidermal tissue has been shown by indirect immunofluorescence to be present in the serum of patients with practolol-induced eye damage. These antibodies and those found in patients with pemphigus were compared for their ability to bind to isolated epidermal cells. Binding was achieved only with the pemphigus antibody, which suggests that it may have a different specificity from the antibody associated with practolol-induced eye damage.
Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD
Authors: G.R. Van Pottelberge, K.R. Bracke, S. Van den Broeck, S.M. Reinartz, C.M. van Drunen, E.F. Wouters, G.M. Verleden, F.E. Vermassen, G.F. Joos, G.G. Brusselle
Journal: European Respiratory Journal (2010)

Plasmacytoid dendritic cells (pDCs) are professional antigen-presenting cells with antiviral and tolerogenic capabilities. Viral infections and autoimmunity are proposed to be important mechanisms in the pathogenesis of chronic obstructive pulmonary disease (COPD). The study aimed to quantify blood dendritic cell antigen 2-positive pDCs in lungs of subjects with or without COPD by immunohistochemistry and flow cytometry, combined with the investigation of the influence of cigarette smoke extract (CSE) on the function of pDCs in vitro . pDCs were mainly located in lymphoid follicles, a finding compatible with their expression of lymphoid homing chemokine receptors CXCR3 and CXCR4. pDC accumulated in the lymphoid follicles and in lung digests of patients with mild to moderate COPD, compared with smokers without airflow limitation and patients with COPD Global Initiative for Chronic Obstructive Lung disease (GOLD) stage III–IV. Exposing maturing pDC of healthy subjects to CSE in vitro revealed an attenuation of the expression of co-stimulatory molecules and impaired interferon-α production. Maturing pDC from patients with COPD produced higher levels of tumour necrosis factor (TNF)-α and interleukin (IL)-8 compared to pDC from healthy subjects. CSE significantly impairs the antiviral function of pDCs. In COPD, a GOLD stage dependent accumulation of pDC in lymphoid follicles is present, combined with an enhanced production of TNF-α and IL-8 by maturing pDCs.
Poor Accumulation of Technetium-99m Glucoheptonate in Sarcoidosis and Other Diffuse Infiltrative Lung Diseases as Compared with Gallium-67 Citrate
Authors: M VORNE, K SAHLSTR??M, K ALANKO
Journal: Clinical Nuclear Medicine (1988)

Forty-two patients with diffuse infiltrative lung diseases were imaged with Ga-67 citrate and Tc-99m glucoheptonate (GH). Twenty patients had sarcoidosis, six had fibrosis, six had tuberculosis, nine had lung infiltration, and one had pleural empyema. The main difference between Ga-67 and Tc-99m GH was the much greater uptake of Ga-67 in sarcoidosis than that of Tc-99m GH. Fifteen patients with sarcoidosis had positive Ga-67 scans but only six had positive Tc-99m GH scans. The results in other diffuse infiltrative lung diseases were almost equal with Ga-67 and Tc-99m GH. Although Tc-99m GH is less expensive and simpler to use, it is not an adequate substitute for Ga-67 in diffuse infiltrative lung diseases.
A grandad writes
Authors: James Owen Drife
Journal: BMJ (2013)

Most of my friends are grandparents, and they all say how enjoyable it is. For a retired obstetrician, however, the final run-up to grandparenthood is a bit fraught. After decades of being called to difficult labours, one becomes too aware of the risks. Statistically, I kept telling myself, things should be OK.

Indeed they were, and once the reassuring text and photo arrived from a distant delivery room overlooking Big Ben, I settled down to write about the …
Hit for six: Miandad's six is metaphor for chaos and complexity
Authors: Vivian S Rambihar
Journal: BMJ (2004)

EDITOR—Miandad's six, as analysed by Abbasi and Khan in their short report,1 is a metaphor that takes us beyond the boundary to new thinking. It is similar to the butterfly metaphor of chaos and complexity science: “A butterfly flapping its wings in Texas causes a tornado in Texas.” This six caused ripples across time and space.