tbuckley/cabot-search huggingface dataset:
THE DIAGNOSIS AND TREATMENT OF "FLOATING KIDNEY."A paper read by special invitation before the Sixth Annual Meeting of the Shelby County Medical Society, Shelbyville, Ind., April 9, 1894.
Authors: HARVEY REED
Journal: JAMA (1894)

The frequency of "floating kidney" associated with its varied complications, together with the errors in diagnosis, certainly warrant our taking up this subject, and considering it for a few moments before this Association. The experience of the writer both as a general practitioner and consultant, has led him to believe that the existence of a floating kidney is more likely to be misunderstood and taken for something else than any other one disease of the abdominal cavity. I have seen floating kidney treated for "lumbago,"also for so-called "sciatic rheumatism." In another case I saw an able practitioner tap it for "ascites," and still another case where it was mistaken for an enlarged ovary. On the other hand, I have seen an enlarged and pendant "gall bladder" filled with gall stones, mistaken for a movable kidney, and the mistake was not discovered until revealed by an operation. With these few examples,
Prison tobacco control policies and deaths from smoking in United States prisons: population based retrospective analysis
Authors: I. A. Binswanger, E. A. Carson, P. M. Krueger, S. R. Mueller, J. F. Steiner, W. J. Sabol
Journal: BMJ (2014)

<b>Objective</b> To determine the mortality attributable to smoking and years of potential life lost from smoking among people in prison and whether bans on smoking in prison are associated with reductions in smoking related deaths. <b>Design</b> Analysis of cross sectional survey data with the smoking attributable mortality, morbidity, and economic costs system; population based time series analysis. <b>Setting</b> All state prisons in the United States. <b>Main outcome measures</b> Prevalence of smoking from cross sectional survey of inmates in state correctional facilities. Data on state prison tobacco policies from web based searches of state policies and legislation. Deaths and causes of death in US state prisons from the deaths in custody reporting program of the Bureau of Justice Statistics for 2001-11. Smoking attributable mortality and years of potential life lost was assessed from the smoking attributable mortality, morbidity, and economic costs system of the Centers for Disease Control and Prevention. Multivariate Poisson models quantified the association between bans and smoking related cancer, cardiovascular and pulmonary deaths. <b>Results</b> The most common causes of deaths related to smoking among people in prison were lung cancer, ischemic heart disease, other heart disease, cerebrovascular disease, and chronic airways obstruction. The age adjusted smoking attributable mortality and years of potential life lost rates were 360 and 5149 per 100 000, respectively; these figures are higher than rates in the general US population (248 and 3501, respectively). The number of states with any smoking ban increased from 25 in 2001 to 48 by 2011. In prisons the mortality rate from smoking related causes was lower during years with a ban than during years without a ban (110.4/100 000 <i>v</i> 128.9/100 000). Prisons that implemented smoking bans had a 9% reduction (adjusted incidence rate ratio 0.91, 95% confidence interval 0.88 to 0.95) in smoking related deaths. Bans in place for longer than nine years were associated with reductions in cancer mortality (adjusted incidence rate ratio 0.81, 95% confidence interval 0.74 to 0.90). <b>Conclusions</b> Smoking contributes to substantial mortality in prison, and prison tobacco control policies are associated with reduced mortality. These findings suggest that smoking bans have health benefits for people in prison, despite the limits they impose on individual autonomy and the risks of relapse after release.
Review: In neuropathy, fibromyalgia, or chronic pain, duloxetine reduces pain but increases adverse events
Authors: Charles C. Engel
Journal: Annals of Internal Medicine (2014)

ACP Journal Club15 April 2014Review: In neuropathy, fibromyalgia, or chronic pain, duloxetine reduces pain but increases adverse eventsCharles C. Engel, MD, MPHCharles C. Engel, MD, MPHRAND Corporation and Uniformed Services University, Arlington, Virginia, USA (C.C.E.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-160-8-201404150-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLunn MP, Hughes RA, Wiffen PJ. Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia. Cochrane Database Syst Rev. 2014;(1):CD007115. https://pubmed.ncbi.nlm.nih.gov/24385423Clinical Impact RatingsGIM/FP/GP: Endocrinology: Neurology: Rheumatology: Author, Article, and Disclosure InformationAuthors: Charles C. Engel, MD, MPHAffiliations: RAND Corporation and Uniformed Services University, Arlington, Virginia, USA (C.C.E.)This article was published at Annals.org on 1 April 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMetformin reduces c-Fos and ATF3 expression in the dorsal root ganglia and protects against oxaliplatin-induced peripheral sensory neuropathy in mice 15 April 2014Volume 160, Issue 8Page: JC12KeywordsAdverse eventsDrugsFibromyalgiaNeuropathic painNeuropathyPainPeripheral neuropathyRelative riskSafety ePublished: 15 April 2014 Issue Published: 15 April 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Clinical Blueprint to Accelerate the Elimination of Tobacco Use
Authors: Michael C. Fiore, Carlos Roberto Jaén
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EPIDURAL INJECTIONS OF NEOARSPHENAMINE
Authors: George B. Hassin
Journal: JAMA (1928)

To the Editor:  —In his note (The Journal, April 7) on my article on Treatment of Tabes by Epidural Injections of Neoarsphenamine, published inThe Journal, February 25, Dr. Norman Viner suggests that the improvement from this treatment should be ascribed to the mechanical action of the fluid injected. He used in his cases of intractable sciatica and other painful conditions in the lower extremities, among which also were two cases of tabes, large amounts of fluids (from 80 to 100 cc.); 20 cc. of 1 per cent procaine hydrochloride was followed by from 50 to 80 cc. of sterile saline or Ringer's solution or petrolatum. Such amounts, decidedly too large for an epidural space even of a big person, may of course produce a mechanical action, but not 8 or 10 cc., the amount used by me. In this treatment I was guided, as pointed out in my article,
Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis
Authors: Annamaria Mazzone, Maria Carmela Epistolato, Raffaele De Caterina, Simona Storti, Simona Vittorini, Silverio Sbrana, Jacopo Gianetti, Stefano Bevilacqua, Mattia Glauber, Andrea Biagini, Piero Tanganelli
Journal: Journal of the American College of Cardiology (2004)
Cerebral mass lesions in patients with AIDS.
Authors: H Montgomery, A Adam, C T Dollery, J Weber, P Volberding, B Griffin, F Scaravilli
Journal: BMJ (1990)

dorsum ofhis left foot, for which his leg was stabilised.Spontaneous swelling of his left thigh developed in the next 24 hours, and radiography showed fractures of the distal metaphysis and the midshaft ofthe left femur (fig 2).The density ofthe bony cortex along the shaft ofthe femur, the normal dense white line at the metaphysis, and the normal band of lucency in the submetaphyseal region were preserved.These features suggested that the fractures were secondary to trauma and were not due to metabolic bone disease of prematurity.Both of the fractures healed satisfactorily after immobilisation.Routine biochemical screening showed a raised serum alkaline phosphatase activity (975 IUll three weeks after delivery and 3685 IU/l at 7 weeks (normal range <220 IU/1)).Serum phosphate concentration was low (0 7 mmol/l). DiscussionThese two cases show how fragile the bones of very premature infants are.The fractures were evident after mniumally invasive procedures in both cases, and the lack of other fractures or other radiological signs of severe metabolic bone disease imply that they were traumatic in origin.Even without definite evidence of bone disease, which is almost universal in infants born at less than 28 weeks' gestation,' premature infants are at risk offractures and extreme care in handling them is essential.
Forty per cent of carers have illness or disability
Authors: A. Iles
Journal: BMJ (2003)

Two thirds of unpaid carers who provide more than 50 hours of care a week say that their health has been affected by caring, says a report published by the Princess Royal Trust for Carers. The report also showed that 40% of carers have an illness or disability themselves.

Of more than five million unpaid carers in England and Wales, over a million provide care for over 50 hours a week.

The report shows that although there is …
Fatal Thyroidectomy following a Leucopenia caused by Thiouracil
Authors: C. E. P. Markby
Journal: BMJ (1946)

Differential DiagnosisFigures taken from the literature and from our own cases show that the two most common conditions with which acute pancreatitis is confused in the clinical diagnosis are perforated peptic ulcer and acute cholecystitis.The treatment of per- forated peptic ulcer is early operation, whereas in acute cholecystitis (although fashion changes from time to time) most surgeons adopt a conservative attitude, operation being per- formed as an emergency only when certain pathological changes occur which make it dangerous to continue with conservative treatment.
Regulation of iron metabolism in HepG2 cells: A possible role for cytokines in the hepatic deposition of iron
Authors: Michiaki Hirayama, Yutaka Kohgo, Hitoshi Kondo, Naoaki Shintani, Koshi Fujikawa, Katsunori Sasaki, Junji Kato, Yoshiro Nhtsu
Journal: Hepatology (1993)

In chronic inflammation it is reported that serum iron is depleted and hepatic iron is increased because of reticuloendothelial system iron blockade. However, recent studies indicate that hepatic parenchymal cells increase the uptake of transferrin-bound iron after in vivo stimulation with bacterial lipopolysaccharide, suggesting that endotoxemia itself or lipopolysaccharide-induced production of inflammation-related cytokines may also be responsible for this phenomenon. In this study the actions of inflammation-related cytokines on the synthesis of iron-binding proteins (transferrin and ferritin) and transferrin receptor and the uptake of transferrin-bound iron were investigated in a human hepatoblastoma cell line, HepG2, which is the most commonly used cell line for examining the regulation of hepatic protein synthesis by cytokines. The cells were exposed to interleukin-1 beta, interleukin-6 or tumor necrosis factor-alpha separately for 24 hr. In each cytokine treatment group, the level of transferrin, which is secreted into the conditioned medium, was found to be decreased compared with that of untreated cells. On the other hand, the biosynthesis of ferritin was markedly elevated after the same treatment. This increase in ferritin by cytokine treatment was diminished when deferoxamine was used concomitantly to deplete intracellular chelatable iron. After stimulation with interleukin-1 beta, interleukin-6 or tumor necrosis factor-alpha, 59Fe-labeled transferrin uptake into the cells was increased by 36%, 48%, or 18%, respectively, and this uptake was inhibited by the addition of excess unlabeled transferrin. A binding study with 125I-labeled diferric transferrin revealed that the three cytokines increased the number of transferrin receptors on the cell surface by 1.15-fold to 1.35-fold.(ABSTRACT TRUNCATED AT 250 WORDS)
The Doctor's PDA and Smartphone Handbook Personal digital assistant
Authors: M. Al-Ubaydli
Journal: Journal of the Royal Society of Medicine (2005)

What do drug dealers and doctors have in common? From the 1980s onwards neither could do their job without a pager. Only by carrying a pager can junior doctors leave their wards, safe in the knowledge that they would be paged about their patients’ needs. The same junior doctors also feel safer knowing that they can page their senior at any time to get advice and support. And of course the code blue message on pagers is essential to the ability of the cardiac arrest team to respond quickly wherever its individual members are dispersed in the hospital.

Handheld computers promise an even bigger qualitative contribution to clinical workflow. Not only can you use a handheld computer to do your clinical work faster and better than before, you can do some things that colleagues without these devices are simply incapable of doing.
Elevated Cardiac Troponin T Is Associated With Higher Mortality and Amputation Rates in Patients With Peripheral Arterial Disease
Authors: Birgit Linnemann, Thilo Sutter, Eva Herrmann, Sebastian Sixt, Aljoscha Rastan, Uwe Schwarzwaelder, Elias Noory, Karlheinz Buergelin, Ulrich Beschorner, Thomas Zeller
Journal: Journal of the American College of Cardiology (2013)
A memorable night
Authors: F. Gillies
Journal: BMJ (2009)

Some years ago, I was the doctor on call for primary and prehospital emergency care. An evening call came in: “Boat carrying refugees has run aground in local waters. Many stranded at cliff bottom.” 

I declined to be winched down to the boat, knowing that the rescued passengers would need to come up sooner or later. They were ferried to a makeshift reception centre, and I made my way there, wondering what to expect. I was not …
Abstract 4683: Correlation of transcript levels of members of the urokinase-type plasminogen activator system with clinico-pathological parameters in prostate cancer .
Authors: Omar Al-Janabi, Helge Taubert, Sven Wach, Robert Stöhr, Maximilian Burger, Wolf Ferdinand Wieland, Andrea Lohse-Fischer, Michael Fröhner, Manfred P. Wirth, Bernd Wullich, Viktor Magdolen, Matthias Kotzsch, Susanne Fuessel
Journal: Cancer Research (2013)

Abstract Background: Members of the urokinase-type plasminogen activator (uPA) system play an important role in tumor progression and angiogenesis in different human malignancies including breast, kidney, colon, stomach and prostate cancer (PCa). Aim of the study was to characterize mRNA expression levels of members of the uPA system in tissue specimens from primary PCa and their potential association with clinico-pathological parameters. Methods: Transcript levels of members of the uPA system, i.e., uPA, uPA receptor (uPAR) and plasminogen activator inhibitor type 1 (PAI-1) were analyzed in a cohort of 132 corresponding pairs of malignant and adjacent non-malignant prostate tissue samples. Relative gene expression levels were determined by quantitative PCR (qPCR) and normalized to the reference gene TATA-box-binding protein (TBP). Potential correlations between the three markers themselves and the clinico-pathological parameters were assessed by Spearman's Rho test and by Fisher's exact test. Results: There were no significant differences in expression levels of uPA system genes between the corresponding malignant and non-malignant tissue specimens. Transcript levels of all members of the uPA system displayed a significant correlation with each other in the tumor tissues. At stratifying uPA, uPAR and PAI-1 expression levels by the median a significant correlation between an elevated expression of uPA and PAI-1 was correlated with higher Gleason score (P = 0.001 and P = 0.007). In addition, a significant positive correlation between uPAR transcript levels and tumor stage was detected (P = 0.025). Conclusion: Our results demonstrate that mRNA expression levels of members of the uPA system correlated with each other and with clinico-pathological parameters. We suggest that transcript levels of uPA system members can be helpful markers for the study of tumor behavior of prostate cancer. Citation Format: Omar Al-Janabi, Helge Taubert, Sven Wach, Robert Stöhr, Maximilian Burger, Wolf Ferdinand Wieland, Andrea Lohse-Fischer, Michael Fröhner, Manfred P. Wirth, Bernd Wullich, Viktor Magdolen, Matthias Kotzsch, Susanne Fuessel. Correlation of transcript levels of members of the urokinase-type plasminogen activator system with clinico-pathological parameters in prostate cancer . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4683. doi:10.1158/1538-7445.AM2013-4683
Ein neues Verfahren mit Vorrichtung zur Hysteroskopie
Authors: F. Menken
Journal: Endoscopy (1971)

A special hysteroscope, total diameter: Fr. 10 (3,3 mm or approx. ⅛ inch) is introduced under visual control. Uterus and cervical channel are tightened by a riding one way-vacuum-cap. This combination enables elevations in all directions during laparohysteroscopy; instillation, biopsy and coagulation possibilities. In 1926 cases we succeeded in inserting the new hysteroscope without anaesthesia and pain.
Normalization of Enhanced Fear Recognition by Acute SSRI Treatment in Subjects With a Previous History of Depression
Authors: Zubin Bhagwagar, Philip J. Cowen, Guy M. Goodwin, Catherine J. Harmer
Journal: American Journal of Psychiatry (2004)

The present study aimed to 1) assess facial expression recognition in subjects with a previous history of major depressive disorder relative to subjects with no history of depression and 2) characterize the effects of acute citalopram infusion on recognition performance for both groups.Unmedicated euthymic women with a history of major depression and matched comparison subjects with no history of depression were given a facial expression recognition task following intravenous infusion of saline or citalopram (10 mg) in a double-blind, between-group design.Following saline infusion, subjects with a previous history of depression showed a selectively greater recognition of fear relative to the subjects with no history of depression. The abnormal fear processing observed in the subjects with a previous history of depression was normalized following citalopram infusion, an effect that was opposite to that seen with the subjects with no history of depression.These results suggest that increased recognition of fear is a trait vulnerability marker for depression and that this is normalized following a single dose of citalopram.
Correlation between muscle glycogen synthase activity and in vivo insulin action in man.
Authors: C Bogardus, S Lillioja, K Stone, D Mott
Journal: Journal of Clinical Investigation (1984)

We have studied the relationship between in vivo insulin-mediated glucose disposal rates, muscle glycogen content, and muscle glycogen synthase activity in 25 southwest American Indians with normal glucose tolerance and with varying degrees of glucose intolerance. Insulin-mediated glucose disposal (M) was measured by using the hyperinsulinemic euglycemic clamp technique at plasma insulin concentrations of 134 +/- 7 and 1709 +/- 72 microU/ml, with simultaneous indirect calorimetry to assess glucose oxidation and storage rates. Muscle glycogen content and glycogen synthase activity were measured in percutaneous muscle biopsy samples obtained from the vastus lateralis muscle before and after the euglycemic clamp procedure. The results showed that muscle glycogen synthase activity at the end of the euglycemic clamp was well correlated with insulin-mediated glucose storage rates at both low (r = 0.50, P less than 0.02) and high (r = 0.78, P less than 0.0001) insulin concentrations; and also correlated with M (r = 0.66, P less than 0.001 and r = 0.76, P less than 0.0001). Similar correlations were observed between the change in muscle glycogen synthase activity and glucose storage rates and M. The change in muscle glycogen synthase activity correlated with the change in muscle glycogen content (r = 0.46, P less than 0.03) measured before and after the insulin infusions. The change in muscle glycogen content did not correlate with glucose storage rates or M. The data suggest the possible importance of glycogen synthesis in muscle in determining in vivo insulin-mediated glucose disposal rates in man.
Mental Retardation: Proceedings of the First International Medical Conference at Portland, Maine
Authors: W. G. Brandstadt
Journal: JAMA (1961)

This is a compilation of 38 papers presented in 5 sessions. Although the sessions have not been given general titles, the first dealt chiefly with anatomic and experimental considerations; the second with birth injuries and natal and prenatal influences; the third with metabolic factors; the fourth with congenital conditions; and the fifth with psychoses in children. The discussions following each session are reported. About half of the papers are provided with summaries, and some are so short that no summary is needed. Most of the papers include a list of references. One paper is in French and one is in German. The rest are in English. Many of the papers are appropriately illustrated, one in color. There is a brief index. This book is not likely to interest the general practitioner, but it should be of great value to anyone who deals with mentally retarded children.
An Alternative Staffing Proposal for Emergency Rooms
Authors: Harvey M. Golomb
Journal: JAMA (1974)

Evaluation of emergency room visits of 2,505 patients seen by one physician in a rural community hospital during a three-year period demonstrated that approximately one third of the visits were truly urgent, and that approximately one half of the patients could have received medical care by a physician's assistant alone. As the demand for emergency room services continues to increase out of proportion to the local population increase, new concepts for coverage need to be devised. Once need is established for more than one physician, a physician's assistant should be utilized as the second member of the team. (<i>JAMA</i>228:329-331, 1974)