Treatment of Severe Pulmonary Hypertension with Inhaled Iloprost
Authors: H.H Leuchte, R.A Baumgartner, J Behr
Journal: Annals of Internal Medicine (2003)

Letters19 August 2003Treatment of Severe Pulmonary Hypertension with Inhaled IloprostH.H Leuchte, MD, R.A Baumgartner, and J Behr, MDH.H Leuchte, MDUniversity of Munich, Grosshadern; 81377 Munich, Germany (Leuchte, Baumgartner, Behr)Search for more papers by this author, R.A BaumgartnerUniversity of Munich, Grosshadern; 81377 Munich, Germany (Leuchte, Baumgartner, Behr)Search for more papers by this author, and J Behr, MDUniversity of Munich, Grosshadern; 81377 Munich, Germany (Leuchte, Baumgartner, Behr)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-4-200308190-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We report successful treatment of severe pulmonary hypertension with inhaled aerosolized iloprost in a patient with Gaucher disease, a lysosomal storage disorder (1-4). A 39-year-old woman with underlying adult Gaucher disease was admitted to our hospital with exertional dyspnea that markedly limited her physical activity (New York Heart Association class III). She had received a diagnosis of type I Gaucher disease at the age of 12 years and had been treated with enzyme replacement therapy (imiglucerase).On presentation, she was able to walk 500 m in 6 minutes. During cycle spiroergometry with a working rate of 60 ...References1. Elstein D, Klutstein MW, Lahad A, Abrahamov A, Hadas-Halpern I, Zimran A. Echocardiographic assessment of pulmonary hypertension in Gaucher's disease. Lancet. 1998;351:1544-6. [PMID: 10326537] CrossrefMedlineGoogle Scholar2. Hoeper MM, Schwarze M, Ehlerding S, Adler-Schuermeyer A, Spiekerkoetter E, Niedermeyer J, . Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med. 2000;342:1866-70. [PMID: 10861321] CrossrefMedlineGoogle Scholar3. Olschewski H, Walmrath D, Schermuly R, Ghofrani A, Grimminger F, Seeger W. Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann Intern Med. 1996;124:820-4. [PMID: 8610951] LinkGoogle Scholar4. Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, . A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N Engl J Med. 1996;334:296-302. [PMID: 8532025] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Munich, Grosshadern; 81377 Munich, Germany (Leuchte, Baumgartner, Behr) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByProstacyclin for pulmonary arterial hypertensionCefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in RatsImatinib as Rescue Therapy in a Patient With Pulmonary Hypertension Associated With Gaucher DiseasePulmonary Arterial Hypertension Related to Gaucher’s Disease, Sarcoidosis, and Other DisordersEndothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell diseaseInhalative iloprost – pharmacology and clinical applicationIloprost in pulmonary hypertensionLes traitements de l’hypertension artérielle pulmonaire à l’heure de la T2A. Recommandations du groupe de travail “Maladies vasculaires pulmonaires” de la Société de pneumologie de langue françaiseIloprost inhalation solution for the treatment of pulmonary arterial hypertensionInhaled Iloprost in Pulmonary Arterial HypertensionSafety and efficacy of Sildenafil therapy in children with pulmonary hypertension 19 August 2003Volume 139, Issue 4Page: 306KeywordsBrainCardiac outputCatheterizationInhalationNatriuretic peptidesOxygenPulmonary arteriesPulmonary diseasesPulmonary hypertensionPulmonary vascular resistance ePublished: 19 August 2003 Issue Published: 19 August 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...