Posterior Pituitary Sigma Receptors and Drug-Induced Syndrome of Inappropriate Antidiuretic Hormone Release
Authors: Russell A. Wilke
Journal: Annals of Internal Medicine (1999)

Letters16 November 1999Posterior Pituitary Sigma Receptors and Drug-Induced Syndrome of Inappropriate Antidiuretic Hormone ReleaseRussell A. Wilke, MD, PhDRussell A. Wilke, MD, PhDUniversity of Wisconsin Hospital and Clinics; Madison, WI 53706 (Wilke)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Long-term administration of neuroleptic agents has occasionally been associated with the development of a drug-induced syndrome of inappropriate antidiuretic hormone release (SIADH). As early as two decades ago, investigators recognized that haloperidol could impair a patient's ability to excrete a free water load (1). In the absence of other abnormalities in endocrine function, long-term administration of haloperidol was observed to induce a state of hyponatremia and serum hypoosmolality. This phenomenon was reversed after discontinuation of therapy with the drug.Although haloperidol is known to function clinically as a pharmacologic antagonist at mesolimbic D2 dopamine receptors, it has ...References1. Peck V, Shenkman L. Haloperidol-induced syndrome of inappropriate secretion of antidiuretic hormone. Clin Pharmacol Ther. 1979;26:442-4. CrossrefMedlineGoogle Scholar2. Su TP. Delineating biochemical and functional properties of sigma receptors: emerging concepts. Crit Rev Neurobiol. 1993;7:187-203. MedlineGoogle Scholar3. Kebabian JW, Tarazi FI, Kula NS, Baldessarini RJ. Compounds selective for dopamine receptor subtypes. Drug Discovery Today. 1997;2:333-40. CrossrefGoogle Scholar4. Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V. Cloning and functional expression of the human type 1 sigma receptor. Biochem Biophys Res Commun. 1996;229:553-8. CrossrefMedlineGoogle Scholar5. Wilke RA, Lupardus PJ, Grandy DK, Rubinstein M, Low MJ, Jackson MB. Potassium channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors. J Physiol (Lond). [In press]. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Wisconsin Hospital and Clinics; Madison, WI 53706 (Wilke) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChlorpromazineDesmopressinSigma 1 Receptor Chaperone: Pharmacology and Therapeutic PerspectivesAntipsychotic-Induced HyponatraemiaTwo Patients With Recurring Syndrome of Inappropriate Secretion of Antidiuretic Hormone on Multiple Atypical AntipsychoticsNEUROLEPTIC DRUGSOTHER HORMONES AND RELATED DRUGSDesmopressin 16 November 1999Volume 131, Issue 10Page: 799KeywordsAntidiuretic hormoneAntipsychoticsChlorpromazineDrug administrationDrug therapyDrugsPotassiumProteinsResearch laboratoriesSyndrome of inappropriate antidiuretic hormone secretion Issue Published: 16 November 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...