tbuckley/cabot-search huggingface dataset:
Abstract 5507: Immunological findings in a phase II immunotherapy study using allogeneic lung cancer cells modified to express alpha(1,3)galactosyltransferase in advanced non-small cell lung cancer (NSCLC)
Authors: Gabriela R. Rossi, Nicholas N. Vahanian, John C. Morris, Jay W. Ramsey, Lucinda Tennant, Charles J. Link
Journal: Cancer Research (2011)

Abstract Background: Alpha(1,3)galactose carbohydrate (αGal) epitopes are highly immunogenic in man. In animal models, vaccination with αGal expressing tumor cells induced rejection of tumor and improved survival. In a phase II anti-tumor immunotherapy study, we evaluated the safety, anticancer activity and immunogenicity of allogeneic human lung cancer cells expressing αGal epitopes HyperAcute-Lung (HAL) vaccines. Methods: Patients with advanced NSCLC received intradermal injections of 300 million HAL vaccine cells every 2 weeks for up to eight doses. Anti-αGal (IgG) and anti-CEA antibodies (Ab) were monitored by ELISA. Cellular immune responses were evaluated by ELISPOT assay (IFN-γ and IL-5). Serum was collected before and at several time points post-immunization. PBMC were collected prior to immunization, after the 4th vaccination and after 8 vaccinations. PBMC were cultured with autologous dendritic cells (DC) pulsed with one of 4 irradiated NSCLC cell lines, three of which were the parental (wild type) cell lines used to generate the vaccine. The fourth was a NSCLC line that was not a component of the vaccine. We compared the reactivity of PBMC stimulated with DC pulsed with these tumor cells pre- and post-immunization in 18 patients with available samples. Results: All patients demonstrated anti-αGal Ab prior to immunization and all responded to vaccination by increasing anti-αGal Ab 2 to 100-fold. Thirty-two patients were tested for anti-CEA Ab. Twenty patients showed significant increases in anti-CEA Ab after immunization. IFN-γ release was detected in 10 of 18 patients evaluated. Patients demonstrating IFN-γ release by ELISPOT after immunization had a median overall survival of 92 weeks (range 40 to 157) comparing favorably with 33.5 weeks (range, 12 to 200) in patients that showed little IFN-γ response. The majority of patients tested showed IL-5 induction after vaccination. In both assays, the HAL1 and HAL2 vaccine cell lines induced greater reactivity on ELISPOT. Patients responding with higher levels of IFN-γ and IL-5 also showed reactivity to the NSCLC cell line that was not a component of the vaccine suggesting that reactivity and possibly cross-priming to shared tumor antigens is induced after vaccination with HyperAcute immunotherapy. Conclusion: Hyperacute anti-tumor immunotherapy induced humoral and cellular responses. Cytokine expression, especially IFN-γ, might be predictive for increased survival. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5507. doi:10.1158/1538-7445.AM2011-5507
A mathematical model of A-V conduction in the rat heart. II. Quantification of concealed conduction
Authors: R. M. HEETHAAR, R. M. DE VOS BURCHART, J. J. DENIER VAN DER GON, F. L. MEIJLER
Journal: Cardiovascular Research (1973)

Journal Article A mathematical model of A-V conduction in the rat heart. II. Quantification of concealed conduction Get access ROBERT M. HEETHAAR, ROBERT M. HEETHAAR From the Department of Medical Physics, University of Utrecht, and from the Department of Cardiology, University Hospital, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar RUUD M. DE VOS BURCHART, RUUD M. DE VOS BURCHART From the Department of Medical Physics, University of Utrecht, and from the Department of Cardiology, University Hospital, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar JAN J. DENIER VAN DER GON, JAN J. DENIER VAN DER GON From the Department of Medical Physics, University of Utrecht, and from the Department of Cardiology, University Hospital, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar FRITS L. MEIJLER FRITS L. MEIJLER From the Department of Medical Physics, University of Utrecht, and from the Department of Cardiology, University Hospital, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 7, Issue 4, July 1973, Pages 542–556, https://doi.org/10.1093/cvr/7.4.542 Published: 01 July 1973
Selenium deficiency and cardiomyopathy
Authors: T. O Cheng
Journal: Journal of the Royal Society of Medicine (2002)

Dr Barbaro (January 2002 JRSM1) questions whether dilated cardiomyopathy due to selenium deficiency (Keshan disease, named after Keshan County, Heilongjiang Province, China where the disease was first discovered in 19352) can be reversed by selenium replacement and further states that ‘controlled prospective clinical trials are lacking’.

As early as 1964, Gu from China noted the existence of a coincidence between the endemic distribution of Keshan disease and that of the white muscle disease of domestic animals2. In 1965 a farm hospital physician from Shanxi Province administered Na2SeO3 to patients with Keshan disease with promising results2. Subsequently investigators from Xian Medical College, Chinese Academy of Medical Sciences and Institute of Geography of Chinese Academy of Sciences collaborated to confirm the aetiological relation between selenium deficiency and Keshan disease3,4.

To evaluate the efficacy of Na2SeO3 in Keshan disease, a prospective study was carried out under strict control among children in the endemic districts of Sichuan Province from 1974 to 1977. The results clearly showed that Na2SeO3 could not only reduce the morbidity and mortality of Keshan disease but also alleviate its clinical course5. Oral selenium supplementation had been shown to reverse the biochemical evidence of the selenium deficiency state in patients with6 or without7 cardiomyopathy in the United States.
The Patient-Centered Medical Home
Authors: Thomas L. Schwenk
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Year in review in intensive care medicine. 2005. I. Acute respiratory failure and acute lung injury, ventilation, hemodynamics, education, renal failure
Authors: Peter Andrews, Elie Azoulay, Massimo Antonelli, Laurent Brochard, Christian Brun-Buisson, Daniel de Backer, Geoffrey Dobb, Jean-Yves Fagon, Herwig Gerlach, Johan Groeneveld, Jordi Mancebo, Philipp Metnitz, Stefano Nava, Jerome Pugin, Michael Pinsky, Peter Radermacher, Christian Richard, Robert Tasker
Journal: Intensive Care Medicine (2006)
417 Subgenomic hepatitis C replicon deriving from a clinical isolate with virologic non-response to IFN-based therapy and IFN resistance in vitro
Authors: B. Schönberger, N. Appel, V. Lohmann, R. Goebel, R. Bartenschlager, S. Zeuzem, C. Sarrazin
Journal: Journal of Hepatology (2006)
Periodontal Disease and Coronary Heart Disease
Authors: James D. Beck, Paul Eke, Gerardo Heiss, Phoebus Madianos, David Couper, Dongming Lin, Kevin Moss, John Elter, Steven Offenbacher
Journal: Circulation (2005)

Background— Results from studies relating periodontal disease to cardiovascular disease have been mixed. Residual confounding by smoking and use of clinical measures of periodontal disease rather than measures of infection have been 2 major criticisms. The aims of this study were to investigate relationships between prevalent coronary heart disease (CHD) and 2 exposures, (1) clinical periodontal disease and (2) IgG antibodies to 17 oral organisms, and to evaluate the role of smoking in these relationships. Methods and Results— Our study is based on a subset of participants in the Atherosclerosis Risk in Communities (ARIC) Study, who received a complete periodontal examination during visit 4 (1996–1998). The exposures were periodontal status and serum IgG antibody levels against 17 periodontal organisms, and the outcome was prevalent CHD at visit 4. Multivariable analyses indicate that periodontal status is not significantly associated with CHD in either ever smokers or never smokers. Similar analyses evaluating antibodies indicate that high antibodies (above the median) to Treponema denticola (odds ratio [OR]=1.7; 95% CI, 1.2 to 2.3), Prevotella intermedia (OR=1.5; 95% CI, 1.1 to 2.0), Capnocytophaga ochracea (OR=1.5; 95% CI, 1.1 to 2.1), and Veillonella parvula (OR=1.7; 95% CI, 1.2 to 2.3) are significantly associated with CHD among ever smokers, whereas Prevotella nigrescens (OR=1.7; 95% CI, 1.1 to 2.6), Actinobacillus actinomycetemcomitans (OR=1.7; 95% CI, 1.2 to 2.7), and Capnocytophaga ochracea (OR=2.0; 95% CI, 1.3 to 3.0) were associated with CHD among never smokers. Conclusions— Clinical signs of periodontal disease were not associated with CHD, whereas systemic antibody response was associated with CHD in ever smokers and never smokers. These findings indicate that the quality and quantity of the host response to oral bacteria may be an exposure more relevant to systemic atherothrombotic coronary events than clinical measures.
Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families
Authors: Catherine M. Phelan, Johnathan M. Lancaster, Patricia Tonin, Curtis Gumbs, Charles Cochran, Ron Carter, Parviz Ghadirian, Chantal Perret, Roxana Moslehi, France Dion, Marie-Claude Faucher, Kiran Dole, Sepideh Karimi, Willliam Foulkes, Hafida Lounis, Ellen Warner, Paul Goss, David Anderson, Catharina Larsson, Steven A. Narod, P. Andrew Futreal
Journal: Nature Genetics (1996)
Poisoning by Accidental Drinking of Trichlorethylene
Authors: J. A. Stephens
Journal: BMJ (1945)

A Case of Blast InjuryAn account of this case is placed on record because of its complex clinical character and its significance in relation to other similar cases which may arise.Blast injuries have been extensively recognized since the Spanish War, and are due to exposure of the effects of big explosions at close range.The clinical findings are well known and require no recapitulation.A more recently recognized type is that met with in sailors who, while in the water, receive the effect of depth charges.Here the lesions are multiple
Seven member societies benefit from BJSM's 16 annual issues: add your society for 2013?
Authors: Karim M Khan
Journal: British Journal of Sports Medicine (2011)

Given all the sales promotions at this time of the year, I am going to succumb and pimp BJSM . Seven member societies, close to two million page views annually, over 10 000 podcasts listened to. The BJSM video site (free on the home page) links 3000–4000 users daily with physical examination teaching. BJSM is the leading sport and exercise medicine social media site – well over 2100 twitter followers (@BJSM_BMJ) track our blog. Controverial editorials, cutting-edge original papers, all focused on sports and exercise clinicians (GPs, specialists and physiotherapists). Did I mention the seven member societies who get greatly discounted BJSM , will receive 16 BJSM issues in 2012 (because the IOC supports …
Randomized Clinical Trials for Cancer Screening: Rationale and Design Considerations for Imaging Tests
Authors: William C. Black
Journal: Journal of Clinical Oncology (2006)

Since the 1960s, there have been revolutionary developments in imaging technology. Undoubtedly, these advances in imaging technology have made it possible to detect most cancers much earlier than they would have presented with clinical signs or symptoms. However, there are harms from screening, including false-positive results and overdiagnosis, and the costs of screening can be substantial. Therefore, screening for cancer must be rigorously evaluated to ensure that it provides more benefit than harm at an acceptable cost. Unfortunately, the evaluation of cancer screening is difficult and susceptible to several forms of bias. Randomized clinical trials are the most valid study design for cancer screening, but they cannot be expected to answer all the questions that arise with the implementation of screening. Decision modeling can be used to extrapolate the results of randomized clinical trials to help inform public policy and individual decision making.
Regional electrophysiological effects of hypokalaemia, hypomagnesaemia and hyponatraemia in isolated rabbit hearts in normal and ischaemic conditions
Authors: R Wolk
Journal: Cardiovascular Research (1998)

Objective: The aims of this study were to establish an isolated working heart model for electrophysiological recordings from the epicardium and endocardium and to examine regional effects of changes in ion concentrations in normal and ischaemic conditions. Methods: Monophasic action potential duration (MAPD90), effective refractory period (ERP) and conduction delay were measured simultaneously in the epicardium and endocardium of rabbit hearts paced at 3.3 Hz, subjected to 30 min of regional ischaemia and 15 min of reperfusion. The hearts were exposed before and throughout ischaemia and reperfusion to hypokalaemia (K+=2 mM), hypomagnesaemia (Mg2+=0.5 mM) or hyponatraemia (Na+=110 mM). Results: In the control hearts, no regional electrophysiological differences were seen before ischaemia, but ischaemia-induced MAPD90 shortening and postrepolarisation refractoriness were greater in the epicardium than in the endocardium and conduction delay increased only in the epicardium. Hypokalaemia shortened ERP in the epicardium (but not endocardium) and increased conduction delay in all areas before ischaemia, but it had no effects during ischaemia. During reperfusion hypokalaemia increased the incidence of recurrent tachyarrhythmias. Hypomagnesaemia had no effect before ischaemia, increased epicardial (but not endocardial) MAPD90 shortening during ischaemia, although it had no pro-arrhythmic action. Hyponatraemia increased conduction delay in all areas before ischaemia and produced asystole or severe bradycardia in all hearts. During ischaemia, hyponatraemia decreased ERP shortening and inducibility of arrhythmias in the epicardium (but not endocardium). Conclusions: We conclude that the more pronounced effect of ischaemia upon the epicardium than the endocardium can be explained by the contact of the endocardium with intracavitary perfusate. We also conclude that changes in ion concentrations may have differential regional electrical effects in normal or ischaemic conditions.
Inverse Relation Between Expression of Gastric Tumor Suppressor Runx3 and Helicobacter Pylori Caga State in Gastric Epithelial Dysplasia
Authors: Woo Chul Chung, Hea Jung Sung, Kang-Moon Lee, Yeon Ji Kim, Hyewon Lee, Ji Han Jung
Journal: Annals of Oncology (2013)
Oral Pemphigus and Bullous Pemphigoid
Authors: Samuel F. Bean
Journal: JAMA (1971)

A patient with oral pemphigus vulgaris and a patient with oral bullous pemphigoid were studied with immunofluorescence. The serum from both patients contained no demonstrable circulating antibodies, but direct staining of specimens obtained from the oral mucosa revealed characteristic fluorescence and established the diagnosis. The lack of circulating epidermal antibodies, therefore, does not rule out pemphigus and bullous pemphigoid. Direct immunofluorescence must be performed in order to exclude these diseases as a cause of chronic blistering of the oral cavity.
Unilateral epidermal naevus resembling acanthosis nigricans*
Authors: HELEN OLLENDORFF CURTH
Journal: British Journal of Dermatology (1976)

A man born with a unilateral epidermal naevus on the right side of the abdomen developed at puberty symmetrical benign acanthosis nigricans in the body folds. Tbe symmetrical eruption later disappeared completely. Tbe unilateral epidermal naevus and tbe symmetrical eruption showed identical bistological features, i.e. tbose of acantbosis nigricans. At tbe age of 32 be developed a muco-epidermoid cancer of the left parotid gland. A decision wbetber tbe association of unilateral epidermal naevi witb malignant tumours occurs witb unusual frequency requires (a) a long follow-up of the patient with the unilateral naevus, (b) a differentiation of the unilateral eruption from unilateral malignant acan-thosis nigricans and (c) statistical evidence.
Targeting the MLL complex in castration-resistant prostate cancer
Authors: Rohit Malik, Amjad P Khan, Irfan A Asangani, Marcin Cieślik, John R Prensner, Xiaoju Wang, Matthew K Iyer, Xia Jiang, Dmitry Borkin, June Escara-Wilke, Rachell Stender, Yi-Mi Wu, Yashar S Niknafs, Xiaojun Jing, Yuanyuan Qiao, Nallasivam Palanisamy, Lakshmi P Kunju, Pranathi M Krishnamurthy, Anastasia K Yocum, Dattatreya Mellacheruvu, Alexey I Nesvizhskii, Xuhong Cao, Saravana M Dhanasekaran, Felix Y Feng, Jolanta Grembecka, Tomasz Cierpicki, Arul M Chinnaiyan
Journal: Nature Medicine (2015)
Abstract 2560: IKKα inactivation predisposes to spontaneous lung squamous cell carcinomas
Authors: Zuoxiang Xiao, Qun Jiang, Jami Willette-Brown, Feng Zhu, Howard A. Young, Fanching Lin, Sandra Burkett, Mahesh Datla, Sichuan Xi, David S. Schrump, Robert H. Wiltrout, Yinling Hu
Journal: Cancer Research (2012)

Abstract Lung cancer is the leading cause of cancer deaths worldwide. To advance the understanding of this disease, various genetically engineered and chemical induced mouse models have been established. However, most animal models resemble human lung adenocarcinoma, and spontaneous lung squamous cell carcinomas (SCCs) mouse models are very rare. Here, we generated Ikkα-KA/KA knock-in mice (KA/KA) in which an ATP binding site of IKKα, Lys 44 was replaced by alanine. The knock-in mice develop severe skin lesions and begin to die after 6 months. We found lung SCCs in some of the mice. To study lung SCC development, we decided to stabilize the skin condition by reintroducing transgenic IKKα by crossing KA/KA with Lori.IKKα transgenic mice to generate KA/KA/Lori.IKKα (KA/KAL) mice. Almost all the KA/KAL (100%) mice at 4 to 6 months of age developed spontaneous lethal lung SCCs. The endogenous IKKα protein level generally markedly declined in an age dependent manner in these IKKα mutant mice. Progenitor cell related markers Sox2, OCT3/4 and Nanog were only increased in the lung SCC tissue but not in the tumor adjacent tissues, implying the involvement of cancer stem cells in lung SCC. Furthermore, we detected substantial increases in Ras and CyclinD1 levels and EGFR, ERK and p38 activities in lung SCCs. On the other hand, we detected reduction in tumor suppressor gene Rb and IαBβ accompanying with reduced IKKα levels in KA/KAL lungs as well as in lung SCCs. Importantly, we observed a similar alteration pattern in mouse and human lung SCCs. Finally, reintroducing IKKα into lung epithelial cells prevented lung SCC development in mice. Collectively, our study supports the tumor suppressing role of IKKα in lung tumorigenesis. This novel lung SCC mouse model may facilitate investigations in pathogenesis, diagnosis, and treatment of human lung SCC disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2560. doi:1538-7445.AM2012-2560
Antithrombin III supplementation reduces heparin requirement and platelet loss during hemodialysis of patients with fulminant hepatic failure
Authors: Peter G. Langley, Rick Keays, Robin D. Hughes, Alastair Forbes, Ullrich Delvos, Roger Williams
Journal: Hepatology (1991)

Previous studies have shown that antithrombin III levels are low in fulminant hepatic failure, and heparin kinetics are abnormal, making control of heparinization difficult during hemodialysis of these patients who are at risk of bleeding. In this study, we have performed a controlled, randomized trial of antithrombin III supplementation on heparin activity, occurrence of bleeding and the platelet count and activation during hemodialysis in 24 patients with fulminant hepatic failure. The treated group of 12 patients was given 3,000 units of antithrombin III before hemodialysis. Antithrombin III supplementation was shown to normalize antithrombin III levels during hemodialysis (prelevels: 0.22 +/- 0.03 U/ml S.E.; at 1 hr 0.99 +/- 0.06 U/ml; p less than 0.001; control prelevels: 0.24 +/- 0.03 U/ml; at 1 hr 0.23 +/- 0.04 U/ml). Total heparin usage was significantly decreased by antithrombin III supplementation (median 5,200 U; range = 2,000 to 13,000) as compared with the control group (median 10,200 U; range = 5,000 to 16,500; p less than 0.005). Blood heparin level (antifactor Xa activity) after the initial bolus was significantly greater in the antithrombin III-supplemented subjects (0.40 +/- 0.07 U/ml compared with 0.22 +/- 0.05 U/ml in the control group; p less than 0.05). The significant reduction in platelet count observed in the control patients (18% +/- 6% at 1 hr; p less than 0.05) did not occur in antithrombin III patients (6% +/- 4% at 1 hr), which was reflected by a lower release of the platelet-specific protein beta-thromboglobulin. Two of 12 patients in both groups showed minor bleeding around vascular access sites during the first hemodialysis.(ABSTRACT TRUNCATED AT 250 WORDS)
Martin Kwame Kari Kari Frimpong Alfred Jonathan Levi Edward Claude Lewis Ernest Donald Page Martin Roberts William Frederick Russell Raoul Peter Gauvain Sandon Thomas Smith Scott William Inglis Dunn Scott John Laing Stevenson Stanley Howard Taylor
Authors: P Farooque, E Barthes-Wilson, A. Price, J. Levi, K. Kelly, S. Sanders, G. Phillips, W F Paveley, T C B Dehn, W R Lee, W. I. D. Scott, M. Vincent, B Silke
Journal: BMJ (1999)

died from pancreatic cancer