Cyclosporine Nephrotoxicity Without Major Organ Transplantation
Authors: N. STANLEY NAHMAN
Journal: Annals of Internal Medicine (1987)

Brief Reports1 March 1987Cyclosporine Nephrotoxicity Without Major Organ TransplantationN. STANLEY NAHMAN Jr, M.D., FERNANDO G. COSIO, M.D., SETH KOLKIN, M.D., JERRY R. MENDELL, M.D., HARI M. SHARMA, M.D.N. STANLEY NAHMAN Jr, M.D., FERNANDO G. COSIO, M.D., SETH KOLKIN, M.D., JERRY R. MENDELL, M.D., HARI M. SHARMA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-400 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCyclosporine is an immunosuppressant used primarily in transplantation (1) and more recently in the therapy of autoimmune disease (2, 3). Nephrotoxicity is a well-recognized complication of cyclosporine and includes functional and anatomical damage (1-6). We report the cases of two patients given cyclosporine for immunologic diseases other than major organ transplantation. Both patients developed irreversible renal functional impairment and had renal biopsy findings consistent with chronic cyclosporine nephrotoxicity.Patient 1:A 25-year-old white woman with a history of congenital glaucoma and recurrent cataracts required several corneal transplants. In July 1984, after bilateral corneal graft placement, the patient was given cyclosporine,...References1. COHENLOERTSCHERRUBINTILNEYCARPENTERSTROM DRMNCT. Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med. 1984;101:667-82. LinkGoogle Scholar2. PALESTINEAUSTINBALOW AHJ. Renal histopathologic alterations in patients treated with cyclosporine for uveitis. N Engl J Med. 1986;314:1293-8. CrossrefMedlineGoogle Scholar3. SVENSONBOHMANHALLGREN KSR. Clinical effects and renal side effects in patients with autoimmune diseases treated with Ciclosporine (CyA). In: SCHINDLER R, ed. Ciclosporine in Autoimmune Diseases. New York: Springer-Verlag; 1985:74-9. CrossrefGoogle Scholar4. MIHATSCHTHIELBASLER MGV. Morphological patterns in cyclosporine-treated renal transplant recipients. Transplant Proc. 1985;17:101-16. MedlineGoogle Scholar5. MYERSROSSNEWTONLUETSCHERPERLROTH BJLJM. Cyclosporine-associated chronic nephropathy. N Engl J Med. 1984;311:699-705. CrossrefMedlineGoogle Scholar6. SOMMERINNESWHITEHURSTSHARMAFERGUSON BJRHR. Cyclosporine-associated renal arteriopathy resulting in loss of allograft function. Am J Surg. 1985;149:756-64. CrossrefMedlineGoogle Scholar7. CURTISLUKEJONESDUBOVSKYWHELCHELDIETHELM JRPEJA. Renal vasoconstriction in cyclosporine-treated (CY) transplant recipients (TXR) without other evidence of nephrotoxicity [Abstract]. Kidney Int. 1986;29:428. Google Scholar8. SIEGLRYFFELPETRIC HBR. Cyclosporine, the renin-angiotensin-aldosterone system, and renal adverse reactions. Transplant Proc. 1983;15(suppl 1):2719-25. Google Scholar9. MossPOWELLFALK NSR. Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats. Proc Nat Acad Sci USA. 1985;82:8222-6. CrossrefMedlineGoogle Scholar10. NEILDROCCHIIMBERTI GLF. Effect of cyclosporine on prostacyclin synthesis by vascular tissue in rabbits. Transplant Proc. 1983;15(suppl 1):2398-400. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: N. STANLEY NAHMANJr, M.D.; FERNANDO G. COSIO, M.D.; SETH KOLKIN, M.D.; JERRY R. MENDELL, M.D.; HARI M. SHARMA, M.D.Affiliations: The Ohio State University Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of cyclosporine on adriamycin induced nephropathyCyclosporine A induced arteriolopathy in a rat model of chronic cyclosporine nephropathyNephrotoxicity of xenobioticsDrug-radiopharmaceutical interactionsEssential hypertension: a renal disease? A review and update of the evidence.Alterations in renal function in psoriasis patients treated with cyclosporin, 5 mg/kg/dayCyclosporine induces elevated procollagen α1 (I) mRNA levels in the rat renal cortexKidney biopsies in control or cyclosporin Atreated psoriatic patients.Cyclosporine therapy for psoriasis: Serum creatinine measurements are an unreliable predictor of decreased renal functionCyclosporine a NephrotoxicityCyclosporin A (Sandimmun®) in autoimmune disordersPilot study of cyclosporin A in patients with symptomatic primary biliary cirrhosisHypertension in cyclosporine-treated renal transplant recipients is sodium dependentCytostatics and immunosuppressive drugs 1 March 1987Volume 106, Issue 3Page: 400-402KeywordsAutoimmune diseasesBiopsyCataractsGlaucomaImmunosuppressivesOrgan transplantationTransplantation ePublished: 1 December 2008 Issue Published: 1 March 1987 PDF downloadLoading ...