Azathioprine and Hypersensitivity Vasculitis
Authors: Suzanne M. Bergman
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 July 1988Azathioprine and Hypersensitivity VasculitisSuzanne M. Bergman, MD, N. Kevin Krane, MD, George Leonard, MD, Maria C. Soto-Aguilar, MD, J. David Wallin, MDSuzanne M. Bergman, MDSearch for more papers by this author, N. Kevin Krane, MDSearch for more papers by this author, George Leonard, MDSearch for more papers by this author, Maria C. Soto-Aguilar, MDSearch for more papers by this author, J. David Wallin, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-1-83_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We report hypersensitivity vasculitis in two patients with end-stage renal disease receiving azathioprine as part of a pretransplant transfusion protocol. The relationship of this reaction to azathioprine was confirmed by recurrence upon rechallenge with the drug.A 56-year-old white man developed renal failure due to chronic interstitial nephritis of unknown cause. Shortly after beginning hemodialysis, he received donor-specific transfusions with concomitant daily azathioprine administration in preparation for a renal transplant from his son. After 2 weeks he developed fever. He was receiving no medication other than a multivitamin and calcium carbonate. He developed headache, myalgias, vomiting, and...References1. LawsonLovattGurtonHennings DGCR. Adverse effects of azathioprine. Adv Drug React Ac Pois Rev. 1984;3:161-71. MedlineGoogle Scholar2. BallinMatkaluk PR. Cutaneous reactions to rheumatological drugs. Clin Rheum Dis. 1982;2:493-516. CrossrefGoogle Scholar3. RosmanBertino MJ. Azathioprine. Ann Intern Med. 1973;79:694-700. LinkGoogle Scholar4. KingLaverFairleyAmes JMKG. Sensitivity to azathioprine. Med J Aust. 1972;2:939-41. CrossrefMedlineGoogle Scholar5. SalvatierraVincentiAmend OFW. Deliberate donor specific blood transfusions prior to living related renal transplantation: a new approach. Ann Surg. 1980;192:543-52. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tulane University School of Medicine New Orleans, LA 70112 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAzathioprine hypersensitivity syndrome: report of two cases with cutaneous manifestationsDrug Hypersensitivity due to Azathioprine with Elevated ProcalcitoninCutaneous Toxicities From Transplantation-Related MedicationsAzathioprine-induced Sweet's syndrome and published work reviewThe cutaneous and systemic manifestations of azathioprine hypersensitivity syndromePruritus and Leucocytoclastic Vasculitis due to AzathioprineDrug Eruption Caused by Azathioprine: Value of Using the Drug-Induced Lymphocytes Stimulation Test for DiagnosisLeucocytoclastic vasculitis in a patient with azathioprine hypersensitivity.Acute febrile toxic reaction in patients with refractory rheumatoid arthritis who are receiving combined therapy with methotrexate and azathioprineAzathioprine hypersensitivity-like reations-a case report and a review of the literatureOther Connective Tissue Disorders and The Use of GlucocorticoidsAssociation of fever, nasal congestion and rise in serum creatinine with azathioprine therapyGeneralized Urticarial Eruption during Azathioprine Treatment for Rheumatoid Arthritis: A Case Report and Review of the Literature 1 July 1988Volume 109, Issue 1Page: 83-84KeywordsDrugsFeversHeadachesHypersensitivityMyalgiaNephritisRenal failureRenal transplantationVasculitisVomiting Issue Published: 1 July 1988 PDF downloadLoading ...