Angiotensin-Converting Enzyme Inhibitors in Black Patients
Authors: Jay S. Kaufman, John M. Flack
Journal: Annals of Internal Medicine (2005)

Letters5 April 2005Angiotensin-Converting Enzyme Inhibitors in Black PatientsJay S. Kaufman, PhD and John M. Flack, MD, MPHJay S. Kaufman, PhDFrom University of North Carolina School of Public Health, Chapel Hill, NC 27516, and Wayne State University School of Medicine, Detroit, MI 48201.Search for more papers by this author and John M. Flack, MD, MPHFrom University of North Carolina School of Public Health, Chapel Hill, NC 27516, and Wayne State University School of Medicine, Detroit, MI 48201.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-7-200504050-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the review by Brewster and colleagues (1) summarizing the effects of single antihypertensive agents on blood pressure and blood pressure control, as reported in clinical studies that enrolled black patients in both the Americas and Africa. The authors highlighted the observation that for angiotensin-converting enzyme (ACE) inhibitors, the summary effect on diastolic control (as a binary outcome) did not differ significantly from placebo. However, they also found that for these agents, changes in both systolic (−7.43 mm Hg) and diastolic (−3.35 mm Hg) blood pressure were each significantly greater than for placebo. The ...References1. Brewster LM, van Montfrans GA, Kleijnen J. Systematic review: antihypertensive drug therapy in black patients. Ann Intern Med. 2004;141:614-27. [PMID: 15492341] LinkGoogle Scholar2. Mokwe E, Ohmit SE, Nasser SA, Shafi T, Saunders E, Crook E, et al. Determinants of blood pressure response to quinapril in black and white hypertensive patients: the Quinapril Titration Interval Management Evaluation trial. Hypertension. 2004;43:1202-7. [PMID: 15117912] CrossrefMedlineGoogle Scholar3. Sehgal AR. Overlap between whites and blacks in response to antihypertensive drugs. Hypertension. 2004;43:566-72. [PMID: 14757779] CrossrefMedlineGoogle Scholar4. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, et al. The structure of haplotype blocks in the human genome. Science. 2002;296:2225-9. [PMID: 12029063] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of North Carolina School of Public Health, Chapel Hill, NC 27516, and Wayne State University School of Medicine, Detroit, MI 48201. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystematic Review: Antihypertensive Drug Therapy in Black Patients Lizzy M. Brewster , Gert A. van Montfrans , and Jos Kleijnen Angiotensin-Converting Enzyme Inhibitors in Black Patients Lizzy M. Brewster , Gert A. van Montfrans , and Jos Kleijnen Metrics 5 April 2005Volume 142, Issue 7Page: 589KeywordsACE inhibitorsAntihypertensive drug therapyBlood pressureDrugsPopulation geneticsPopulation statistics ePublished: 5 April 2005 Issue Published: 5 April 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...