tbuckley/cabot-search huggingface dataset:
708. Combination of Allogeneic Hematopoietic Stem Cell Transplantation and Allogeneic MHC Gene Transfer Against Solid Cancers
Authors: Kazunori Aoki, Masaki Ohashi, Miwa Kushida, Kimiko Yoshida, Masaki Mandai, Gary J. Nabel, Teruhiko Yoshida
Journal: Molecular Therapy (2005)

Top of pageAbstract
Introduction: Allogeneic hematopoietic stem cell transplantation (HSCT) often leads to a significant graft-versus-tumor (GVT) immune response mediated by donor T cells. Allogeneic HSCT is recently applied not only for hematological malignancies but also for solid cancers such as renal cancer. It is commonly believed that the target antigens of GVT in MHC-matched allogeneic HSCT are minor histocompatibility antigens and tumor-specific antigens, and the benefit of GVT activity is often offset by the occurrence of graft-versus-host disease (GVHD). In order to enhance the immune recognition of tumor antigens by donor T cells while preventing exacerbation of GVHD, we combined an allogeneic MHC gene transfer with allogeneic HSCT against solid cancers in this study.

Methods and Results: We established a mouse allogeneic HSCT model: bone marrow cells of DBA-2 mice (H-2d) were transplanted into lethally irradiated BALB/c mice (H-2d). Since CT26 murine colon cancer cells have an aggressive tumorigenecity in syngeneic BALB/c mice, the intratumoral injection of H-2Kb plasmid complexed with DMRIE/DOPE into subcutaneous xenografts of CT26 provided a limited antitumor effect in naive mice. By contrast, the H-2Kb gene transfer showed a significant synergistic antitumor effect without exacerbation of GVHD in recipient mice of HSCT. In the in vitro cytotoxic assay, CT26-specific cytotoxic T cells were effectively induced in the transplanted mice with the H-2Kb gene transfer, suggesting that the H-2Kb gene transfer enhanced the recognition of tumor antigens by donor T cells or T cells derived from donor stem cells, although the immune response to host histocompatibility antigens did not get worse. Remarkably, the H-2Kb gene transfer was effective in stimulating potent and long-lasting antitumor activity in recipient mice of HSCT. Conclusion: These results demonstrate that allogeneic MHC gene transfer after allogeneic HSCT can stimulate potent antitumor effects without exacerbation of GVHD, and this combined strategy has important implications in the therapeutic development for the solid malignancies.
Relationship between plasma testosterone and dihydrotestosterone concentrations and male facial hair growth
Authors: M.J.G. FARTHING, A.M. MATTEI, C.R.W. EDWARDS, A.M. DAWSON
Journal: British Journal of Dermatology (1982)

Journal Article Relationship between plasma testosterone and dihydrotestosterone concentrations and male facial hair growth Get access M.J.G. FARTHING, M.J.G. FARTHING Department of Gastroenterology, St Bartholomew's Hospital, West Smithfield, London, EC1 Dr M.J.G.Farthing, Tufts University School of Medicine, Department of Medicine, Division of Geographic Medicine, 136 Harrison Avenue Box 22, Boston, Massachusetts 02111, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar A.M. MATTEI, A.M. MATTEI Department of Gastroenterology, St Bartholomew's Hospital, West Smithfield, London, EC1 Search for other works by this author on: Oxford Academic Google Scholar C.R.W. EDWARDS, C.R.W. EDWARDS Department of Endocrinology, St Bartholomew's Hospital, West Smithfield, London, EC1 Search for other works by this author on: Oxford Academic Google Scholar A.M. DAWSON A.M. DAWSON Department of Gastroenterology, St Bartholomew's Hospital, West Smithfield, London, EC1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 5, 1 November 1982, Pages 559–564, https://doi.org/10.1111/j.1365-2133.1982.tb00406.x Published: 01 November 1982 Article history Accepted: 09 February 1982 Published: 01 November 1982
Production of Heart Sounds by the Cardiac Catheter
Authors: FREDERIC L. ELDRIDGE, HERBERT N. HULTGREN
Journal: Circulation (1959)

Extra heart sounds are frequently produced by the cardiac catheter in the human subject during routine cardiac catheterization. They are associated with a characteristic pressure artefact, which suggests that the sound is produced by back-and-forth movement of the catheter tip across the pulmonic valve. Similar sounds, and also murmurs, can be produced by catheter passage across pulmonary or aortic valves in excised canine hearts. The fact that such artificial sounds can be produced by the intracardiac catheter suggests gests that some caution must be used in interpreting phonocardiograms obtained during cardiac catheterization.
Temporal Arteritis and Sulfonamide Therapy
Authors: Stanford I. Lamberg
Journal: JAMA (1967)

<h3>To the Editor:—</h3> With the deluge of new drugs and rapid increase in drug reactions, it is common to assume that an unusual disease is related to a predating medication. This frequency of newly noted drug reactions makes careful documentation essential or medicine soon will be without a pharmacopeia. Lee and Andrews report in "Temporal Arteritis Developing in the Course of Sulfonamide Therapy" that we now have another hazardous drug reaction to blame on sulfonamides (<b>200</b>:720, 1967). Their conclusions seems to me unwarranted. The patient was not rechallenged with the drug, and although a rechallenge would not have been warranted because of potential dangers, it would have constituted the only real proof of cause. The patient did not have a skin rash from the sulfonamide, as he was said to have had with a previous exposure. The sulfonamide was not the only drug he was taking. The patient is
The American Alcoholic
Authors: G. W. Richmond
Journal: JAMA (1975)

<h3>To the Editor.—</h3> I would like to comment on Dr. Donald W. Goodwin's review of<i>The American Alcoholic</i>by William Madsen (229:1112, 1974). I believe Dr. Goodwin missed the whole point of the book, which is really an excellent description of Alcoholics Anonymous (AA) and an excellent account of the success of AA in helping to overcome this addiction, particularly in view of the notable failure of psychiatry. I agree that Mr. Madsen does spend considerable time on reference, but I believe he is trying to gather as many ideas and details as possible about the disease in one place. The bibliography is certainly exhaustive, and those of us who are actively engaged in handling alcoholics will find much of the material in this book of great value.
Medical Thinking: The Psychology of Medical Judgment and Decision Making
Authors: William R. Best
Journal: JAMA (1987)

There is a wealth of information in this volume on current knowledge about how we actually do, or theoretically might, acquire, evaluate, and make decisions to act on patient-related information in the practice of medicine. The bibliography contains more than 500 citations, beginning in the 1950s and reaching a crescendo in the 1980s. The case of "Mrs K.," adapted from<i>Harper's</i>magazine, makes a dramatic introduction to these topics. A seriously ill patient, with initially puzzling, multisystem disease, died after 25 days in the hospital after having received 31 roentgenographic examinations, 136 drug doses in addition to IVs, and laboratory studies costing $11000—for a total hospital bill of $47 311. Should her- case- havebeen handled differently to favor a better outcome, cause less discomfort, or reduce cost? Implicit in this question are considerations of gathering and evaluating patient information, deciding what the totality of information at a particular time means
Gaseous monoxides: a new class of micro vascular regulator in the liver
Authors: Makoto Suematsu, Yoshiyuki Wakabayashi, Yuzuru Ishimura
Journal: Cardiovascular Research (1996)

Gaseous monoxides such as nitric oxide (NO) and carbon monoxide (CO) have recently attracted great interest as a regulator of cell and organ functions. When exposed to endotoxin, cytokines or ischemia-reperfusion, the liver produces larger amounts of NO than those in the control via the activity of inducible NO synthase which can alter a variety of organ functions such as sensitivity of vascular tone to catecholamine, mitochondrial membrane potential, biliary transport and tissue regeneration. On the other hand, the liver constitutively produces CO through the reaction of heme oxygenase. CO generated in the liver tissue can reach sinusoidal vessels and relax fat-storing Ito cells--the liver-specific microvascular pericytes covering the sinusoidal wall--and thereby serves as an endogenous modulator of vascular tone. Two isoforms of the CO-generating enzyme have been characterized: heme oxygenase-1 which is inducible by a variety of stressors, and heme oxygenase-2 which constitutes the major enzyme activity under physiological conditions in the liver. Although it is still unknown whether excessive CO generation by the inducible heme oxygenase activity may preserve or jeopardize the integrity of microvascular function in the liver, the potential importance of this double-edged molecule has just emerged much like nitric oxide, another gaseous molecule that was established as a neurovascular mediator inducing vascular cell relaxation. This article provides an overview of the pathophysiological roles of these gaseous monoxides in regulation of microvascular function in the liver.
A comparison of the culture and growth of dermal papilla cells from hair follicles from non-balding and balding (androgenetic alopecia) scalp
Authors: V. A. RANDALL, N. A. HIBBERTS, K. HAMADA
Journal: British Journal of Dermatology (1996)

Male pattern baldness is a common, androgen-dependent skin problem in adult men which is not well understood, although androgens are believed to act on the hair follicle via the mesenchyme-derived dermal papilla situated in the middle of the hair follicle bulb. Since dermal papilla cells retain specific characteristics in culture, such as hair-growth promoting ability and appropriate features of the mechanism of androgen action, dermal papilla cells from follicles undergoing androgen-stimulated miniaturization may provide a useful in vitro model system. Therefore, dermal papilla cells have been derived from intermediate follicles from balding and nearly clinically normal sites of men with androgenetic alopecia. Balding dermal papillae were much smaller than non-balding ones and grew much less well under normal growth conditions. Supplementing the medium with human serum, rather than fetal calf serum, increased both the yield of established cultures and the number and health of the dermal papilla cells produced. Non-balding cells also grew faster in human serum. Balding cells retained the normal fibroblastic shape and aggregative behaviour of dermal papilla cells, but always grew less well than non-balding cells. Nearly clinically normal dermal papillae were similar, or slightly smaller, in size to non-balding ones, but their growth resembled balding cells. Since balding dermal papilla cells can be cultured, though with much greater difficulty than nonbalding ones, and exhibit differing growth characteristics to non-balding cells, they merit further investigation which may increase our understanding of, and ability to control, androgenetic alopecia.
THE NEED OF TEACHING MEDICAL ETHICS
Authors: ARTHUR DEAN BEVAN
Journal: JAMA (1927)

In the efforts which have been made by the American Medical Association to elevate the standards of medical education since the creation of the Council on Medical Education in 1904 and the establishment of its annual conferences, great advances have been made in our medical schools, in our teaching hospitals and dispensaries, in our preliminary requirements in the medical curriculum, in the hospital year and in our postgraduate work. One important field has not, however, been given sufficient attention: medical ethics. With the great advances of modern medicine and the greater range of application of medical and surgical therapy, there has developed a greater opportunity of misusing the sacred privileges of the physician and surgeon. The time has arrived when the organized profession, i. e., the American Medical Association, should take steps to do everything in its power to correct such evils as exist and to educate medical students and
The delta T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage.
Authors: W Holtmeier, Y Chowers, A Lumeng, E Morzycka-Wroblewska, M F Kagnoff
Journal: Journal of Clinical Investigation (1995)

The majority of gamma/delta T cell receptors (TCR) in the human intestinal mucosa are thought to use the TCRDV1 (V delta 1) variable region gene segment, whereas gamma/delta T cells in the circulation predominantly express the TCRDV2 (V delta 2) gene segment. delta T cell receptors that use the TCRDV2 variable region gene segment generally have been regarded as highly diverse, whereas those that use the TCRDV1 gene segment are oligoclonal, whether present in the intestinal tract or in peripheral blood. We report herein that oligoclonality is a general feature of the peripheral delta T cell receptor repertoire in healthy human adults, irrespective of the variable region used and regardless of whether gamma/delta T cells reside in the intestinal mucosa or in peripheral blood. In addition, the delta T cell receptor repertoire is shown to be highly compartmentalized between such sites as the colon and peripheral blood, relatively stable over at least a 10-16-mo period, and unique in each individual. Further, the spectrum of variable region genes used by delta T cell receptor transcripts in the human colon is greater than previously recognized. Thus, in addition to the TCRDV1 and TCRDV2 variable region gene segments, delta T cell receptors in normal intestinal mucosa can use TCRDV3 (V delta 3) and TCRAV (V alpha) gene segments which, in some individuals, comprise a significant component of the mucosal delta T cell receptor repertoire. Our studies indicate that the potential of delta T cell receptors for extensive diversity is not reflected in the mature human repertoire. Moreover, these findings suggest a model wherein the delta T cell receptor repertoire in the colon and peripheral blood is shaped by selection and clonal expansion of gamma/delta T cells that ultimately seed throughout the length of the colon mucosa and populate the circulation.
Nine in 10 GPs believe they are being criticised for political gain, poll shows
Authors: J. Wise
Journal: BMJ (2014)

A poll has found that four in five family doctors believed that England’s health secretary, Jeremy Hunt, was seeking to undermine public trust in general practitioners.1 However, the Department of Health has criticised the poll for asking leading questions.

The poll by the Guardian newspaper questioned 1008 GPs who belonged to a panel run by the networking website doctors.net.uk. The survey found that 83% of respondents agreed with the statement that “Jeremy Hunt is seeking …
Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis
Authors: Julia Skokowa, Doris Steinemann, Jenny E. Katsman-Kuipers, Cornelia Zeidler, Olga Klimenkova, Maksim Klimiankou, Murat Ünalan, Siarhei Kandabarau, Vahagn Makaryan, Renee Beekman, Kira Behrens, Carol Stocking, Julia Obenauer, Susanne Schnittger, Alexander Kohlmann, Marijke G. Valkhof, Remco Hoogenboezem, Gudrun Göhring, Dirk Reinhardt, Brigitte Schlegelberger, Martin Stanulla, Peter Vandenberghe, Jean Donadieu, C. Michel Zwaan, Ivo P. Touw, Marry M. van den Heuvel-Eibrink, David C. Dale, Karl Welte
Journal: Blood (2014)
THE PULSE PRESSURE AS AN INDEX OF THE SYSTOLIC OUTPUT
Authors: Percy M. Dawson, Lemuel W. Gorham
Journal: The Journal of Experimental Medicine (1908)

ON THE BASIS OF THESE FACTS WE FEEL JUSTIFIED IN MAKING THE FOLLOWING ASSERTION: Under normal conditions and during various procedures (namely, stimulation of the vagus centrally and peripherally, of the saphenus nerve centrally, and of the annulus Vieussentis, intravenous transfusion of 0.7 per cent. sodium chloride solution, intra-arterial transfusion of strong carbonate, bleeding and asphyxia) the pulse pressure is a reliable index of the systolic output.
Heat Waves and Heat-Related Illness
Authors: Patrick G. O’Malley
Journal: JAMA (2007)

Laurent Argaud, MD, PhD; Tristan Ferry, MD; Quoc-Hung Le, MD; Aurélia Marfisi, MD; Diana Ciorba, MD; Pierre Achache, MD; Roland Ducluzeau, MD; Dominique Robert, MDBackgroundDuring August 2003, Europe sustained a severe heat wave that resulted in 14 800 heat-related deaths in France. Most of these excess deaths occurred in urban areas, where maximal temperatures broke all records. Heatstroke is the most severe form of heat-related illness. The clinical course of heatstroke in urban areas of temperate countries is poorly documented.MethodsDuring the French heat wave (August 1-20, 2003), we conducted a prospective study in a university hospital located in Lyon, one of the largest metropolitan areas in France. We evaluated survival and functional outcome for 2 years and looked for factors influencing the prognosis.ResultsA total of 83 patients presented with heatstroke. The 28-day and 2-year mortality rates were 58% and 71%, respectively. Mortality was influenced as early as admission by the level of fever and the number of organ dysfunctions. Multivariate analysis revealed an independent contribution to mortality if patients came from an institution (hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.05-3.71), used long-term antihypertensive medication (HR, 2.17; 95% CI, 1.17-4.05), or presented at admission with anuria (HR, 5.24; 95% CI, 2.29-12.03), coma (HR, 2.95; 95% CI, 1.26-6.91), or cardiovascular failure (HR, 2.43; 95% CI, 1.14-5.17). Most surviving patients exhibited a dramatic alteration of their functional status at 1 and 2 years.ConclusionsHeatstroke is associated with poor outcomes in temperate urban areas. This could be explained at least in part by our lack of experience. Western temperate countries need to be more prepared for future heat waves.
HYDATID CYST OF THE APPENDIX
Authors: R. H. Slocumb
Journal: JAMA (1927)

Reports on cases of hydatid cysts involving the intestine are exceedingly rare. In Lyon's<sup>1</sup>report of 241 cases in a series in North America the intestine was involved in only one case. There have been several cases reported as abdominal hydatids, but there is no mention of the intestine. Garrahan<sup>2</sup>reports a multivesicular abdominal hydatid in a girl, aged 10 years. Cameron<sup>3</sup>reports a large suppurating abdominal cyst in a girl, aged 10 years. The foregoing cases, with the exception of Lyon's series have been reported from countries outside of North America, where the disease occurs rarely. The disease is infrequent enough to warrant the report of the following case: <h3>REPORT OF CASE</h3> F. R., a German, aged 45, seen, June 23, 1927, had a temperature of 102 F. and complained of pain and tenderness in the right iliac region. Examination of the abdomen revealed a marked right
Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering
Authors: Alireza Moshaverinia, Sahar Ansari, Chider Chen, Xingtian Xu, Kentaro Akiyama, Malcolm L. Snead, Homayoun H. Zadeh, Songtao Shi
Journal: Biomaterials (2013)
Multiple-checkpoint inhibition of thymic stromal lymphopoietin–induced TH2 response by TH17-related cytokines
Authors: Sofia I. Bogiatzi, Maude Guillot-Delost, Antonio Cappuccio, Jean-Christophe Bichet, Olfa Chouchane-Mlik, Marie-Hélène Donnadieu, Emmanuel Barillot, Philippe Hupé, Katerina Chlichlia, Eleni I. Efremidou, Selim Aractingi, Olivier Bayrou, Vassili Soumelis
Journal: Journal of Allergy and Clinical Immunology (2012)
FGF23 neutralization improves chronic kidney disease–associated hyperparathyroidism yet increases mortality
Authors: Victoria Shalhoub, Edward M. Shatzen, Sabrina C. Ward, James Davis, Jennitte Stevens, Vivian Bi, Lisa Renshaw, Nessa Hawkins, Wei Wang, Ching Chen, Mei-Mei Tsai, Russell C. Cattley, Thomas J. Wronski, Xuechen Xia, Xiaodong Li, Charles Henley, Michael Eschenberg, William G. Richards
Journal: Journal of Clinical Investigation (2012)

Chronic kidney disease-mineral and bone disorder (CKD-MBD) is associated with secondary hyperparathyroidism (HPT) and serum elevations in the phosphaturic hormone FGF23, which may be maladaptive and lead to increased morbidity and mortality. To determine the role of FGF23 in the pathogenesis of CKD-MBD and development of secondary HPT, we developed a monoclonal FGF23 antibody to evaluate the impact of chronic FGF23 neutralization on CKD-MBD, secondary HPT, and associated comorbidities in a rat model of CKD-MBD. CKD-MBD rats fed a high-phosphate diet were treated with low or high doses of FGF23-Ab or an isotype control antibody. Neutralization of FGF23 led to sustained reductions in secondary HPT, including decreased parathyroid hormone, increased vitamin D, increased serum calcium, and normalization of bone markers such as cancellous bone volume, trabecular number, osteoblast surface, osteoid surface, and bone-formation rate. In addition, we observed dose-dependent increases in serum phosphate and aortic calcification associated with increased risk of mortality in CKD-MBD rats treated with FGF23-Ab. Thus, mineral disturbances caused by neutralization of FGF23 limited the efficacy of FGF23-Ab and likely contributed to the increased mortality observed in this CKD-MBD rat model.
Healthy Workplace: Employers, Employees Benefit
Authors: Charles Marwick
Journal: JAMA (1992)

PREVENTION pays off. Improving workplace conditions, educating employees about their health, and encouraging healthy life-styles "reduce costs, so that both employers and employees benefit," says Carson Beadle, president of Health Project, of which C. Everett Koop, MD, former surgeon general of the US Public Health Service, is honorary chair. Beadle spoke at a Washington, DC, meeting during which eight companies were honored with the first Koop National Health Awards for developing programs to improve health standards and reduce costs. <h3>Cost Versus Benefit</h3> "Every one of these programs decreases worksite health care costs well in excess of the program's expense," Beadle says. He cites as an example a 15% reduction in physician visits by employees of Blue Shield of California, one of the companies honored. Other speakers included Mary Jane England, MD, president, Washington Business Group on Health. She says that those involved in the worksite program of the pharmaceutical company
Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils
Authors: Kiyoshi Takeda, Björn E Clausen, Tsuneyasu Kaisho, Tohru Tsujimura, Nobuyuki Terada, Irmgard Förster, Shizuo Akira
Journal: Immunity (1999)
Choosing Wisely in Anesthesiology
Authors: Onyi C. Onuoha, Valerie A. Arkoosh, Lee A. Fleisher
Journal: JAMA Internal Medicine (2014)

To develop a "top-five" list of unnecessary medical services in anesthesiology, we undertook a multistep survey of anesthesiologists, most of whom were in academic practice, and a consequent iterative process with the committees of the American Society of Anesthesiologists. We generated a list of 18 low-value perioperative activities from American Society of Anesthesiologists practice parameters and the literature. Starting with this list and proceeding with a 2-step survey using a 5-point Likert scale questionnaire, we eventually identified 5 common activities that are of low quality or benefit and high cost and have poor evidence supporting their use. The 2 preoperative practices in the top-five list addressed the avoidance of unindicated baseline laboratory studies or diagnostic cardiac stress testing. The 3 intraoperative practices involved the avoidance of the routine use of the pulmonary artery for cardiac surgery and the use of packed red blood cells or colloid when not indicated.