The Initial Electrophysiologic Disturbance in Experimental Myocardial Infarction.
Authors: Miguel Gambetta
Journal: Annals of Internal Medicine (1969)

s1 May 1969The Initial Electrophysiologic Disturbance in Experimental Myocardial Infarction.Miguel Gambetta, M.D., Roderick W. Childers, M.D.Miguel Gambetta, M.D., Roderick W. Childers, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1076_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe fundamental electrical properties of the heart—conduction, excitability, and refractoriness—were studied in 30 open-chest, anesthetized dogs during the first 15 min after anterior descending or circumflex coronary artery occlusion. The latter was accomplished by direct ligation or by clamping a femoral-distal coronary arterial shunt. During the first minute, conduction time of impulses into the ischemic zone of the ventricle was shortened, and excitability was enhanced. These changes were prevented by distal perfusion of the occluded artery with nonoxygenated Tyrode® but not by pretreatment with propranolol, 1 mg/kg intravenously. After 1 min, conduction time was progressively delayed, and the amplitude of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byR-wave amplitude changes measured by electrocardiography during early transmural ischemiaR wave amplitude change with ischemiaThe infarct Q wave: foretaste and aftertaste; presentiment and recallR wave amplitude in ischemia, injury, and infarctionR wave of the surface and intracoronary electrogram during acute coronary artery occlusionNonhomogeneous electrophysiological changes and the bimodal distribution of early ventricular arrhythmias during acute coronary artery occlusionIntramyocardial conduction: a major determinant of R-wave amplitude during acute myocardial ischemia.Electrophysiological changes and ventricular arrhythmias in the early phase of regional myocardial ischemia.Electrophysiology of Reentrant Ventricular Arrhythmias in the Late Myocardial Infarction PeriodRelationship between changes in left ventricular bipolar electrograms and regional myocardial blood flow during acute coronary artery occlusion in the dog.Demonstration of re-entry within the canine specialized conduction systemElectrophysiologic effects of partial coronary flow reduction in the exposed canine heart. Effects of ischemia and ischemic-induced regional hypothermia on refractoriness and conduction delay.Time-related changes in the Q-T interval in acute myocardial infarction: Possible relation to local hypocalcemiaRe-entrant ventricular arrhythmias in the late myocardial infarction period. 1. Conduction characteristics in the infarction zone.Re-entrant ventricular arrhythmias in the late myocardial infarction period. 2. Patterns of initiation and termination of re-entry.Alterations in canine myocardial excitability during ischemia.Electroide cather recording during malignant ventricular arrythmia following experimental acute myocardial ischemia. Evidence for re-entry due to conduction delay and block in ischemic myocardium.The Efficacy of Antiarrhythmic Agents During Acute Myocardial Ischemia and the Role of Heart RateCharacterization and Localization of Ventricular Arrhythmias Resulting from Myocardial Ischemia and InfarctionEarly and Late Effects of Coronary Artery Occlusion on Canine Purkinje FibersElectrophysiological Properties of Canine Purkinje Cells in One-Day-Old Myocardial InfarctionCoronary Care: The Understanding and Treatment of Atrial and Ventricular Dysrhythmias 1 May 1969Volume 70, Issue 5Page: 1076-1076KeywordsArteriesCoronary arteriesLigation assayMyocardial infarction Issue Published: 1 May 1969 PDF downloadLoading ...