Clinical Relevance of Gastrointestinal Hormones: Emerging Interest in Hypergastrinemia
Authors: Tadataka Yamada
Journal: Annals of Internal Medicine (1993)

Editorials15 February 1993Clinical Relevance of Gastrointestinal Hormones: Emerging Interest in HypergastrinemiaTadataka Yamada, MDTadataka Yamada, MDUniversity of Michigan Medical Center, Ann Arbor, MI 48109-0368.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The concept of gastrointestinal hormones arose from experiments conducted by Bayliss and Starling in 1902 when they described the action of secretin, now known to be a peptide hormone produced in the small intestine that controls pancreatic secretion via the circulation [1]. It is ironic that this description of a humoral regulatory system was reported a full 2 years before Pavlov was awarded the Nobel Prize for his theories on the control of organ function principally by nerves. Since the discovery of secretin, much has been learned about hormonal systems. Indeed, it seems that each year brings the identification of ...References1. Bayliss WM, Starling EH. Mechanism of pancreatic secretion. J Physiol. (London). 1902; 28:325-53. Google Scholar2. Warren JR. Unidentified curved bacilli on gastric epithelium in active chronic gastritis (Letter). Lancet. 1983; 1:1273-5. Google Scholar3. Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis (Letter). Lancet. 1983; 1:1273-5. Google Scholar4. Peterson W, Barnett C, Evans DJ Jr, Feldman M, Richardson C, Walsh J, et al. Role of H. pylori in gastric acid secretion and serum gastrin concentrations in healthy subjects and patients with duodenal ulcer (Abstract). Gastroenterology. 1991; 100:A140. Google Scholar5. Kaneko H, Nakada K, Mitsuma T, Uchida K, Furusawa A, Maeda Y, et al. Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach. Dig Dis Sci. 1992; 37:409-16. Google Scholar6. Moss SF, Legon S, Bishop AE, Polak JM, Calam J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet. 1992; 340:930-2. Google Scholar7. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991; 325:1127-31. Google Scholar8. Winsett OE, Townsend CM Jr, Glass EJ, Thompson JC. Gastrin stimulates growth of colon cancer. Surgery. 1986; 99:302-7. Google Scholar9. Smith JP, Solomon TE. Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Gastroenterology. 1988; 95:1541-8. Google Scholar10. Wong K, Beardshall K, Waters CM, Calam J, Poston GJ. Postprandial hypergastrineamia in patients with colorectal cancer. Gut. 1991; 32:1352-4. Google Scholar11. Pounder R, Smith J. Drug-induced changes of plasma gastrin concentration. Gastroenterol Clin North Am. 1990; 19:141-53. Google Scholar12. Borch K, Renvall H, Liedberg G. Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology. 1985; 88:638-48. Google Scholar13. Jensen RT. Gastrinoma as a model for prolonged hypergastrinemia in man. In: Walsh JM; ed. Gastrin. New York: Raven Press (In press). Google Scholar14. Lamberts R, Creutzfeldt W, Struber HG, Brunner G, Solcia E. Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth and gastritis. Gastroenterology. 1993 (In press). Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Michigan Medical Center, Ann Arbor, MI 48109-0368.Corresponding Author: Tadataka Yamada, MD, Department of Internal Medicine, 3101 Taubman Center, University of Michigan Medical Center, Ann Arbor, MI 48109-0368. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHelicobacter pylori and Gastrointestinal DiseaseRole of Growth Factors in Pancreatic Endocrine Cells: Growth and Differentiation 15 February 1993Volume 118, Issue 4Page: 309-311KeywordsCarcinoid tumorGastrinGastritisHormonesHypergastrinemiaPeptide hormonesSomatostatinStomachUlcersZollinger Ellison syndrome Issue Published: 15 February 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...