tbuckley/cabot-search huggingface dataset:
Immunofluorescent Test for Lupus Erythematosus: Relation to Renal Disease
Authors: Thomas K. Burnham
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In the recent report by Caperton et al (222:935, 1972), no correlation was found between the incidence of renal disease and a positive immunofluorescent "band" test in clinically normal skin from patients with systemic lupus erythematosus (SLE). The authors obtained clinically normal results for skin tests from the back of the upper arm or from over the scapula. Both these sites usually represent light-exposed skin. Baart de la Faille-Kuyper and Cormane already reported in 1968 that the band was found much more frequently in light-exposed clinically normal skin with lupus erythematosus than in skin obtained from usually light-protected areas.<sup>1</sup>Fifteen of 15 patients with lupus erythematosus (100%), demonstrated a band in light-exposed uninvolved skin taken from the extensor surface of the forearm, whereas only four of these patients (26.6%) showed a band in skin obtained from clinically normal skin from the back at light-protected sites.<sup>1</sup>We
Multivitamins, Nutrition, and Antiretroviral Therapy for HIV Disease in Africa
Authors: Barbara Marston, Kevin M. De Cock
Journal: New England Journal of Medicine (2004)

Readers could be forgiven for being confused by the literature on micronutrients and the pathogenesis of human immunodeficiency virus (HIV) disease. Micronutrients play important roles in maintaining immune function and neutralizing the reactive oxygen intermediates produced by activated macrophages and neutrophils in their response to microorganisms. Serum and plasma measurements of vitamins and trace elements, which are imperfect indicators of body stores, have shown that deficiencies are common among HIV-infected persons, especially those who are underprivileged, such as women in developing countries, and injection-drug users. A vicious cycle has been envisaged in which undernourished HIV-infected persons have micronutrient deficiencies, leading . . .
Textbook of Radiotherapy
Authors: Luther W. Brady
Journal: JAMA (1967)

Patterson wrote in his first edition of<i>Treatment of Malignant Diseases by Radiotherapy</i>, "The presentation of a definite outlook is of more value than the discussion of different principles and practices." However, he does not mean to imply that it is the only, the best, or the most correct method, in order to leave the reader with something concrete. The author of the present text has succeeded admirably in writing a book useful for trainees in radiotherapy, giving them a sequential exposition by anatomical sites of the place that radiotherapy holds in the management of cancer. It is also an excellent reference for other specialists dealing with the problems of cancer, since it shows how radiation therapy techniques may be employed successfully and properly in its management. The author provides clinical background for the justification and understanding of techniques, but the reader is expected to be familiar with the classical
Efficacy and Safety of Tadalafil Once Daily in the Treatment of Men With Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: Results of an International Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Hartmut Porst, Edward D. Kim, Adolfo R. Casabé, Vincenzo Mirone, Roberta J. Secrest, Lei Xu, David P. Sundin, Lars Viktrup
Journal: European Urology (2011)
Incidence and Prognosis of Sustained Arrhythmias in Critically Ill Patients
Authors: Djillali Annane, Véronique Sébille, Denis Duboc, Jean-Yves Le Heuzey, Nicolas Sadoul, Erik Bouvier, Eric Bellissant
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Sustained arrhythmias are common in postoperative and cardiac intensive care units (ICUs), but their incidence and prognosis in general ICUs have never been reported.To estimate the incidence and prognosis of sustained arrhythmias in a general ICU population.Prospective, multicenter, 1-month inception cohort study.A total of 1,341 patients were included: 12% (163/1,341) had sustained arrhythmias, including 8% (113/1,341) and 2% (30/1,341) with supraventricular and ventricular arrhythmias, respectively, and 2% (30/1,341) with conduction abnormalities. In-hospital death rates were 17% (205/1,178) in patients without arrhythmia and 29% (33/113) in patients with supraventricular arrhythmias (odds ratio [OR], 1.95; 95% confidence interval [CI], 1.27-3.01), 73% (22/30) in patients with ventricular arrhythmias (OR, 13.20; 95% CI, 5.79-30.10), and 60% (18/30) in patients with conduction abnormalities (OR, 7.46; 95% CI, 3.52-15.82). Neurological sequel rates were 6% (55/973) in arrhythmia-free survivors and 15% (12/80) in survivors with supraventricular arrhythmias (OR, 2.92; 95% CI, 1.45-5.89), 38% (3/8) in survivors with ventricular arrhythmias (OR, 7.53; 95% CI, 1.60-35.50), and 17% (2/12) in survivors with conduction abnormalities (OR, 8.77; 95% CI, 1.65-46.57). After adjusting for prognosis factors and propensity scores, ventricular arrhythmias still increased mortality (OR, 3.53; 95% CI, 1.19-10.42) but supraventricular arrhythmias and conduction abnormalities did not.Sustained arrhythmias are observed in 12% of patients admitted to general ICUs. Ventricular arrhythmias increase the risk of death.
Crossing Boundaries—Violation or Obligation?
Authors: Gordon D. Schiff
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitamin C modulates TET1 function during somatic cell reprogramming
Authors: Jiekai Chen, Lin Guo, Lei Zhang, Haoyu Wu, Jiaqi Yang, He Liu, Xiaoshan Wang, Xiao Hu, Tianpeng Gu, Zhiwei Zhou, Jing Liu, Jiadong Liu, Hongling Wu, Shi-Qing Mao, Kunlun Mo, Yingying Li, Keyu Lai, Jing Qi, Hongjie Yao, Guangjin Pan, Guo-Liang Xu, Duanqing Pei
Journal: Nature Genetics (2013)
Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses
Authors: Diane R. Gold, Gordon R. Bloomberg, William W. Cruikshank, Cynthia M. Visness, John Schwarz, Meyer Kattan, George T. O'Connor, Robert A. Wood, Melissa S. Burger, Rosalind J. Wright, Frank Witter, Aviva Lee-Parritz, Rhoda Sperling, Yoel Sadovsky, Alkis Togias, James E. Gern
Journal: Journal of Allergy and Clinical Immunology (2009)
Serum Cortisol Levels in Cushing's Syndrome After Low- and High-Dose Dexamethasone Suppression
Authors: MICHAEL W. ASHCRAFT
Journal: Annals of Internal Medicine (1982)

To standardize the cutoff points of serum Cortisol values in the evaluation of Cushing's syndrome during a low- and high-dose dexamethasone suppression test, daily serum Cortisol measurements (0800 hours and 1600 hours) and urinary 17-hydroxycorticosteroids were compared (Study A). Forty-seven subjects were studied (11 normal subjects, 15 patients with Cushing's disease, five patients with adrenal adenoma, and 16 subjects with suspected Cushing's syndrome). A serum cortisol measurement at 1600 hours of more than 5μg/dL on low-dose dexamethasone suppression and more than 10 μg/dL on high-dose dexamethasone were ascertained to be nonsuppressed values. A baseline dehydroepiandrosterone-sulfate value less than 0.4 μg/ mL indicated patients with an adrenocorticol adenoma. Study B was a prospective study of 17 patients in which no urine samples were collected. Serum Cortisol levels, obtained at 1600 hours on the second day of low- and high-dose dexamethasone, accurately allowed a differential diagnosis of suspected Cushing's syndrome. Serum Cortisol measurements can replace the urinary 17hydroxycorticoid measurements in a cost-effective manner without a decrease in the degree of accuracy.
Exogenous particles in lymph nodes in patients with shrinking pleuritis with atelectasis.
Authors: L Dernevik
Journal: Thorax (1985)

Shrinking pleuritis with atelectasis is a disease in which a compression atelectasis of the lung is caused by shrinking of the inflamed visceral pleura. This reaction has been attributed to asbestos. By means of scanning electron microscopy, with computerised x ray spectrophotometry and x ray diffraction analysis, tissue samples from the lymph nodes of patients with the disease and control subjects were examined for other particles of possible aetiological importance. The results would suggest, however, that asbestos is the most important factor in the aetiology of shrinking pleuritis with atelectasis.
Infections Complicating Mycosis Fungoides and Sézary Syndrome
Authors: Peter I. Axelrod, Bennett Lorber, Eric C. Vonderheid
Journal: JAMA (1992)

To determine, in patients with mycosis fungoides and Sézary syndrome, the incidence of infections, the importance of nosocomial infections, and the epidemiologic factors associated with cutaneous and visceral infections.Retrospective inception cohort study at a university medical center referral clinic.Three hundred fifty-six patients with mycosis fungoides or Sézary syndrome.Incidence rates for specific infections, and multivariate risk ratios for demographic and clinical factors associated with infection.Cutaneous bacterial infection was most common (17.0 infections per 100 patient-years), followed by cutaneous herpes simplex virus and herpes zoster virus infection (3.8 infections per 100 patient-years), bacteremia (2.1 infections per 100 patient-years), bacterial pneumonia (1.7 infections per 100 patient-years), and urinary tract infection (1.4 infections per 100 patient-years). Twenty-seven percent of herpesvirus infections disseminated on the skin but none disseminated to internal organs. Pneumonia or bacteremia was present in 88% of patients who died of infection. Only three patients had invasive fungal or protozoal infection. Nosocomial infections accounted for 19% of cutaneous bacterial infections, 59% of bacteremias, 62% of pneumonias, and 88% of infections leading to death. By logistic and Cox regression, the presence of extracutaneous involvement with lymphoma was the most important independent risk factor for recurrent bacterial skin infection (risk ratio [RR], 12; 95% confidence interval [CI], 1.2 to 120), disseminated herpesvirus infection (RR, 28; 95% CI, 2.7 to 290), bloodstream infection (RR, 5.5; 95% CI, 1.7 to 18), and death from infection (RR, 15; 95% CI, 3.6 to 64).Community-acquired bacterial skin infections are a common cause of morbidity in patients with mycosis fungoides and Sézary syndrome but are usually treated without hospital admission. Bacteremia and pneumonia, which are usually nosocomial, are the major infectious causes of death. Advanced disease stage, independent of corticosteroids and other therapies, is the most important risk factor for both cutaneous and systemic infections.
P06.13 * OUTCOME AND PROGNOSTIC FACTORS IN ATYPICAL AND MALIGNANT MENINGIOMA: UNIVERSITY OF FLORENCE EXPERIENCE
Authors: B. Detti, S. Scoccianti, D. Greto, S. Cassani, S. Cappelli, I. Giacomelli, L. Bordi, V. Di cataldo, E. Monteleone, L. Livi
Journal: Neuro-Oncology (2014)

AIM: This study aim to retrospectively assess prognostic factors and outcome in 68 patients with atypical and malignant meningiomas. MATERIAL AND METHODS: Data of 68 patients affected by meningioma between january 1993 and december 2011 were retrospective analyzed. In 80 % of the patients surgical resection was macroscopical; in 51 patients histology resulted atypical and in 17 malignant. All patients performed radiation treatment, of them 56% after surgical resection, 26% at the first relapse and 18% at the secon relapse, mean dose delivered was 54.6 Gy. RESULTS: Median follow-up was 6.7 years, (range 1.5-19.9 years). The actuarial overall survival rates at 5- and 10-year were 74.1 and 45.6 %, respectively. At univariate analysis age >60 years and radiotherapy dose >52 Gy showed statistical significance, (p = 0.04 and p = 0.03, respectively). At the multivariate analysis only radiotherapy dose >52 Gy maintained the statistical significance, (p = 0.037). The 5- and 10-year disease-free survival rates were 76.5 and 69.5 % respectively, on univariate analysis they were significantly influenced by size >5 cm (p = 0.04) and grading (p = 0.003), both still remained significant prognostic factors at multivariate analysis (p = 0.044 and p = 0.0006, respectively). Treatment related toxicities were limited: 16 % of the patients experienced grade ≤ 2 acute side effects, no ≥ grade 3 acute toxicity was exeperienced. CONCLUSIONS: In study, age and radiotherapy dose were associated with a longer overall survival, while disease free survival was influenced by preoperative size and grading of the tumor . Although there were some advantages in terms of overall survival for patients treated with postoperative radiotherapy, the benefit did not reach the significance. Multicenter prospective studies are necessary to clarify the management and the correct timing of radiotherapy in such a rare disease.
Fever: Blessing or Curse?
Authors: Richard B. Johnson
Journal: Annals of Internal Medicine (1994)

Letters15 December 1994Fever: Blessing or Curse?Richard B. Johnson, MDRichard B. Johnson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-12-199412150-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Mackowiak [1] proposes that the “preservation of the species rather than survival of the individual [is] the essence of evolution.” This concept is logically untenable. Evolution results in the formation of new species and in the extinction of others. If species are preserved, no evolution occurs.Richard Dawkins' book The Selfish Gene[2] is a cogent polemic against “the erroneous assumption that the important thing in evolution is the good of the species (or the group) rather than the good of the individual (or the gene).”Dr. Mackowiak advances the hypothesis that “the febrile response and its ...References1. Mackowiak PA. Fever: blessing or curse? A unifying hypothesis. Ann Intern Med. 1994; 120:1037-40. Google Scholar2. Dawkins R. The Selfish Gene. New York: Oxford University Press; 1976:2. Google Scholar3. Johnson RB. The group selection of variola minor in the Americas: an anthroponootic analogue of the myxomatosis epizootic in Australia. Med Hypoth. 1986; 19:341-4. Google Scholar4. Johnson RB. Human disease and the evolution of pathogen virulence. J Theor Biol. 1986; 122:19-24. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedicine and evolution: time for a new paradigm? 15 December 1994Volume 121, Issue 12Page: 983KeywordsCholeraDiarrheaDysenteryFeversInfectious diseasesPathogensPulmonary diseasesRabiesSystemic diseasesUpper respiratory tract infections Issue Published: 15 December 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique Hématologique
Authors: Hervé Avet-Loiseau, Axelle Daviet, Christophe Brigaudeau, Evelyne Callet-Bauchu, Christine Terré, Marina Lafage-Pochitaloff, François Désangles, Sylvie Ramond, Pascaline Talmant, Régis Bataille
Journal: Blood (2001)
Objective Measurements of the Effects of Drugs on Driver Behavior
Authors: James G. Miller
Journal: JAMA (1962)

A battery of tests has been used to measure the effects of several drugs upon skills used in driving an automobile and in some other related activities. The tests included a driver trainer test, a steadiness test, and visual tests, and they were applied to both normal subjects and patients. The effects of various dosages of drugs were determined; the list included meprobamate, dextro amphetamine sulfate, prochlorperazine, benactyzine HCl, chlordiazepoxide, isothipendyl HCl, syrosingopine, and others. It is suggested that objective tests of the kind used here be used regularly in evaluating new compounds that can affect the central nervous system.
Highly efficient liposome-mediated gene transfer of inducible nitric oxide synthase in vivo and in vitro in vascular smooth muscle cells
Authors: K Veit
Journal: Cardiovascular Research (1999)

The efficient introduction of regulatory genes into vascular smooth muscle cells (SMCs) is one of the most promising options for gene therapy of cardiovascular diseases. Cationic liposome-mediated gene transfer may become a favorable transfection technique with regard to patient's safety for in vivo administration. However, this method until now has its limitation in a low transfection efficiency. Therefore, the present study was designed to improve cationic liposome-mediated transfection of rabbit vascular SMCs in vitro and in vivo, in order to enhance transfection efficiency and present an optimized system which may offer a potential therapeutic benefit for in vivo application.Optimized lipofection of rabbit SMCs with the mammalian expression vector pE-N1 and the reporter gene green fluorescent protein resulted in a mean transfection efficiency of about 50%. The unique transfection of rabbit SMCs in vitro and in vivo with the inducible isoform of human nitric oxide synthase (NOSII), using the same vector, resulted in a successful transient transcription and translation of a functionally active human NOSII in rabbit SMC, persisting 5-6 days. We could further demonstrate that the transfection procedure and the transgene product did neither induce necrosis nor apoptosis under the conditions chosen and did not result in the induction of endogenous NOSII of transfected SMCs.These findings indicate potential therapeutic relevance for this nonviral gene transfer system for in vivo gene therapy for cardiovascular diseases.
742 ACCURATE IDENTIFICATION OF LIVER FIBROSIS IN CHRONIC HCV PATIENTS USING A CONTINUOUS 13C METHACETIN BREATH TEST: A VALIDATION STUDY OF A NOVEL DECISION MAKING TOOL
Authors: G. Lalazar, O. Pappo, R. Safadi, Y. Ashur, B. Mullhaupt, O. Goetze, Y. Ilan
Journal: Journal of Hepatology (2008)
Valvular Myofibroblast Activation by Transforming Growth Factor-β
Authors: Gennyne A. Walker, Kristyn S. Masters, Darshita N. Shah, Kristi S. Anseth, Leslie A. Leinwand
Journal: Circulation Research (2004)

The pathogenesis of cardiac valve disease correlates with the emergence of muscle-like fibroblasts (myofibroblasts). These cells display prominent stress fibers containing α-smooth muscle actin (α-SMA) and are believed to differentiate from valvular interstitial cells (VICs). However, the biological factors that initiate myofibroblast differentiation and activation in valves remain unidentified. We show that transforming growth factor-β1 (TGF-β1) mediates differentiation of VICs into active myofibroblasts in vitro in a dose-dependent manner, as determined by a significant increase in α-SMA and the dramatic augmentation of stress fiber formation and alignment. Additionally, TGF-β1 and increased mechanical stress function synergistically to enhance contractility. In turn, contractile valve myofibroblasts exert tension on the extracellular matrix, resulting in a dramatic realignment of extracellular fibronectin fibrils. TGF-β1 also inhibits valve myofibroblast proliferation without enhancing apoptosis. Our results are consistent with activation of a highly contractile myofibroblast phenotype by TGF-β1 and are the first to connect valve myofibroblast contractility with pathological valve matrix remodeling. We suggest that the activation of contractile myofibroblasts by TGF-β1 may be a significant first step in promoting alterations to the valve matrix architecture that are evident in valvular heart disease.
Sensory nerve activation in airway microvascular permeability in guinea-pig late allergic response
Authors: Y. Mashito, M. Ichinose, H. Sugiura, M. Miura, N. Endoh, K. Shirato
Journal: European Respiratory Journal (1999)

Because both bradykinin and tachykinins have a potent inflammatory action, these molecules may be involved in the late allergic response. The role of these molecules in airway microvascular permeability during the late allergic response in sensitized guinea-pigs was investigated. Three weeks after ovalbumin sensitization, the animals were pretreated with bradykinin B2 receptor antagonist HOE 140, neurokinin 1 receptor antagonist CP 96,345 or vehicle, 30 min before the ovalbumin inhalation challenge. The occurrence of the late allergic response was determined by a two-fold increase in the transpulmonary pressure from the baseline values. The microvascular permeability in the trachea was assessed by an index defined as the ratio of the area of vasculature labelled by Monastral blue dye (area density %). Significant microvascular permeability and eosinophil accumulation were observed during the late allergic response. Both the bradykinin and substance P concentrations in the bronchoalveolar lavage fluid were increased during the late allergic response. Pretreatment with HOE 140 suppressed the substance P elevation. Both HOE 140 and CP 96,345 also inhibited the airway microvascular permeability during the late allergic response without affecting the eosinophil accumulation in the airways. These findings suggest that bradykinin-mediated sensory nerve activation may play a role in microvascular permeability during the late allergic response in guinea-pigs.
A CASE OF POISONING FROM VERONAL.
Authors: JOHN GERMANN
Journal: JAMA (1906)

<h3>Patient.</h3> —E. G., aged 22, male, a school teacher, unmarried, was found in a state of profound coma from which he could not be roused and died 79 hours afterward. <h3>History.</h3> —The attending physician makes the following statement: "E. G., a young man of intelligence and a patient of over two years' standing, came to my office on the afternoon of January 13 and stated that he was suffering from insomnia. I advised against the use of any drug, telling him that the drug habit was worse than the rum habit. I advised him to give up a night class he was teaching and to try a hot bath at bedtime. He said that he could not give up the class and that he got home too late to take a bath. After some further talk I was about to write for a simple sedative when he asked me if