Cytomegalovirus Infection, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, and Crohn's Disease
Authors: MARTIN S. TOPIEL
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Cytomegalovirus Infection, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, and Crohn's DiseaseMARTIN S. TOPIEL, M.D., JEFFREY J. KUTSCHER, M.D., STEPHEN J. PILIPSHEN, M.D., KEITH J. QUINTON, M.D.MARTIN S. TOPIEL, M.D., JEFFREY J. KUTSCHER, M.D., STEPHEN J. PILIPSHEN, M.D., KEITH J. QUINTON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-302_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Cytomegalovirus infection can present as a life-threatening disease involving multiple organ systems in immunocompromised patients (1, 2). We report the case of a patient with Crohn's disease who developed cytomegalovirus hepatitis and colitis and was successfully treated with 9-(1,3-dihydroxy-2-propoxymethyl)guanine (BW B759U; Burroughs Wellcome Co., Research Triangle Park, North Carolina).A 34-year-old woman had fevers, chills, diarrhea, and progressive abdominal pain for 2 weeks. She had a 12-year history of Crohn's disease complicated by two ileocolonic resections. She required chronic prednisone therapy in alternating daily doses of 15 and 20 mg and azathioprine therapy at 50 mg/d.On...References1. ELIONFURMANFYFEDEMIRANDABEAUCHAMPSCHAEFFER GPJPLH. Selectivity of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc Natl Acad Sci USA. 1977;74:5716-20. CrossrefMedlineGoogle Scholar2. TOLLILIVELLIPERRYCRUMPACKERFIELD MTHCA. Effects of the nucleoside analog 2′-nor-2′-deoxyguanosine on human cytomegalovirus replication. Antimicrob Agents Chemother. 1984;25:247-52. CrossrefMedlineGoogle Scholar3. FELSENSTEIND'AMICOHIRSCH DDM. Treatment of cytomegalovirus retinitis with 9-(2-hydroxy-1-(hydroxymethyl)ethoxymethyl)guanine. Ann Intern Med. 1985;103:377-80. LinkGoogle Scholar4. MASURLANEPALESTINE HHA. Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men. Ann Intern Med. 1986;104:41-4. LinkGoogle Scholar5. SHEPPDANDLIKERDEMIRANDA DPP. Activity of 9-(2-hydroxy-1-(hydroxymethyl)ethoxymethyl)guanine in the treatment of cytomegalovirus pneumonia. Ann Intern Med. 1985;103:368-73. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memorial Hospital of Burlington County Mount Holly, NJ 08060 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKaposi's sarcoma and cytomegaloviral ileocolitis complicating long-standing Crohn's disease in an HIV-negative patientHepatitis related to cytomegalovirus infection in two patients with Crohn's disease treated with azathioprineGastrointestinal Cytomegalovirus Infection Complicating Crohn's Disease in an Adolescent Without AIDS 1 August 1986Volume 105, Issue 2Page: 302-303KeywordsAbdominal painColitisCrohn's diseaseCytomegalovirus infectionDiarrheaFeversHepatitis A Issue Published: 1 August 1986 PDF downloadLoading ...