tbuckley/cabot-search huggingface dataset:
Calcification in Soft Tissues
Authors: Vera L. Stewart
Journal: JAMA (1983)

THE PRESENCE of calcification in soft tissues and its radiological appearance may aid in the diagnosis and treatment of certain systemic disorders. When the soft-tissue calcification occurs with an elevated serum calcium-phosphorus ion product, it is termed<i>metastatic calcification</i>. In these patients, amorphous calcium phosphate and calcium hydroxyapatite crystals are deposited in multiple locations. The appearance of metastatic calcification is typical but not disease specific. Microscopically, the deposition of calcium salts may be observed in the lung, stomach, and kidney. Vascular calcification is also present, as are large, periarticular soft-tissue masses. When soft-tissue calcification occurs in altered, necrotic, or dead tissue in patients whose serum calcium and phosphorus levels are normal, it is called<i>dystrophic calcification</i>, which is influenced by multiple physiological factors. These include serum calcium, phosphorus and alkaline phosphatase,<sub>p</sub>H of the tissue, vitamin D, hormonal balance, blood supply, and injury of soft tissues.<sup>1</sup> <h3>Metastatic Calcification</h3>
Graft-versus-host disease-like eruption in a patient with non-Hodgkin's lymphoma
Authors: I.R. PARKES, I. ZAKI, A. STEVENS, J.M. DAVIES, B.R. ALLEN
Journal: British Journal of Dermatology (1997)

Graft-versus-host disease (GVHD) is most commonly seen as a complication of bone marrow transplantation, although it can occur whenever tissue or blood products are given whereby immunologically competent donor lymphocytes react against host tissues. A 65-year-old man with non-Hodgkin's lymphoma developed a severe widespread erosive eruption of the skin and mucosal surfaces. Clinically and histologically it was identical to cutaneous GVHD even though the patient had never received tissue or blood products. He failed to respond to conventional therapy for GVHD, but his skin improved significantly on treating his underlying lymphoma, which eventually proved fatal. There are two previous reports of GVHD associated with malignancy but we believe this to be the first case secondary to a lymphoma.
Risk of suicide in twins: Intelligence of twins and singletons may explain risk
Authors: M. Voracek
Journal: BMJ (2003)

EDITOR—Tomassini et al presented evidence for a lower suicide rate of twins compared with singletons.1 However, they did not present any data supporting their preferred explanative factor (“strong family ties”) for this finding, and their explanation is therefore speculative. Other causal factors need to be considered. I give one …
THERAPEUTIC VALUE OF TRANSUTERINE GAS INFLATION
Authors: REUBEN PETERSON
Journal: JAMA (1923)

The injection of carbon dioxid gas under pressure through the uterus to determine the patency of the fallopian tubes has been employed rather extensively in the gynecologic clinic of the University of Michigan for the last three years. During this period the Rubin test, with some modifications, has been used, since it was thought to be the best method of controlling the flow of gas, regulating its pressure and estimating the amount of gas passed through the uterus and fallopian tubes into the peritoneal cavity.  Not only was the Rubin technic employed to determine the patency of the tubes, but it was the method of choice for the introduction of sufficient gas into the peritoneal cavity to allow the taking of satisfactory roentgenograms whereby pathologic changes in the pelvis could be carefully studied. If, under suitable pressure and after repeated attempts, the gas failed to pass by the transuterine route,
Dextran-coated fluorapatite crystals doped with Yb3+/Ho3+ for labeling and tracking chondrogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo
Authors: Xiaoqing Hu, Jingxian Zhu, Xiyu Li, Xin Zhang, Qingyang Meng, Lan Yuan, Jiying Zhang, Xin Fu, Xiaoning Duan, Haifeng Chen, Yingfang Ao
Journal: Biomaterials (2015)
The Effect of Blood Glucose Concentration on Labile A1c in Diabetic Patients
Authors: R Kawahara, T Amemiya, T Komori, Y Hirata
Journal: Diabetes Care (1985)

We investigated the magnitude of labile A1c in total A1c measured rapidly by a chromatographic method, and whether or not there was an effect of blood glucose before and after a meal on labile A1c in 94 type I and 178 type II diabetic subjects. There were strong correlations between serum glucose and labile A1c both in type I (r = 0.76, P &amp;lt; 0.001) and in type II diabetic subjects (r = 0.72, P &amp;lt; 0.001). These relationships did not change before and after the meal. As labile A1c increased in proportion to blood glucose, it could be calculated from the blood glucose level in simultaneous blood samples. In type I diabetic subjects, below the 100-mg/dl glucose level labile A1c was negligible, and above 100 mg/dl about 0.35% labile A1c was increased every 50-mg/dl increment of glucose. In type II diabetic subjects, below a 150-mg/dl glucose level labile A1c was in the normal range (0.58 ± 0.15%), and above the 150-mg/dl glucose level every 50-mg/dl increment of glucose increased about 0.3% of labile A1c. If this process is used, stable A1c can be calculated easily from total A1c and coincident serum glucose, even though labile A1c is not removed by incubation.
Reviews, Notes, and Listings: Rheumatology: Clinical Examination in Rheumatology
Authors: Bruce Rothschild
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 July 1993Reviews, Notes, and Listings: Rheumatology: Clinical Examination in RheumatologyBruce Rothschild, MDBruce Rothschild, MDNortheastern Ohio Universities College of Medicine, Rootstown, OH 44272.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-1-199307010-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical Examination in RheumatologyMichael and John Doherty. 144 pages. London: Wolfe Publishing; 1992.The predominantly hospital-based nature of medical school and resident training programs has long denied students of medicine exposure to the real problems faced by practitioners. These students have not been sensitized to the need to become facile with the recognition of rheumatologic-musculoskeletal disease. Education in the techniques of rheumatologic examination has generally been inadequate, which perhaps reflects the limited coverage of the topic in most general physical diagnosis texts. An addendum is definitely needed, and the Doherty's manual provides a readable, excellently illustrated approach to physical diagnosis of ... Author, Article, and Disclosure InformationAuthors: Bruce Rothschild, MDAffiliations: Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1993Volume 119, Issue 1 Page: 96 Keywords Fibromyalgia Knees Neurology Orthopedics Rheumatoid arthritis Rheumatology Shoulders ePublished: 15 August 2000 Issue Published: 1 July 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Treatment of Condyloma Acuminatum
Authors: Gordon C. Sauer
Journal: JAMA (1968)

ABSTRACT To the Editor:— In The Journal (204:555, 1968) Dr. John Spratt replied to a question from Dr. Walter Schloss regarding the therapy of giant penile condyloma acuminatum.From the correspondence one must assume that the most accepted therapy for the treatment of venereal warts or condyloma acuminatum was not used. This consists of podophyllum in various forms. The mixture I use most frequently is a 25% solution in compound tincture of benzoin. This is applied in the office and repeated in a week or two weeks, depending on the severity of the reaction.If and when this podophyllum therapy fails then electrosurgical procedures should be instituted.
Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum
Authors: Juliane Najm, Denise Horn, Isabella Wimplinger, Jeffrey A Golden, Victor V Chizhikov, Jyotsna Sudi, Susan L Christian, Reinhard Ullmann, Alma Kuechler, Carola A Haas, Armin Flubacher, Lawrence R Charnas, Gökhan Uyanik, Ulrich Frank, Eva Klopocki, William B Dobyns, Kerstin Kutsche
Journal: Nature Genetics (2008)
Comparison of in vivo and in vitro haemodynamic function in experimental heart failure: use of echocardiography
Authors: M. P. Pye, M. Black, S. M. Cobbe
Journal: Cardiovascular Research (1996)

Objective: To compare in vivo and in vitro haemodynamic performance in two models of experimental cardiac failure. To validate echocardiography as a means of non-invasive assessment of left ventricular dysfunction in rabbits. Methods: Cardiac failure was induced by doxorubicin injection (1-1.25 mg · kg−1 twice weekly for 8 weeks (n = 16) or coronary ligation (n = 12), with 12 controls. Left ventricular diastolic dimension and ejection fraction were assessed in vivo by echocardiography. The doxorubicin-treated and ligation hearts were subdivided by ejection fraction >0.40 or <-0.40 into non-failing and failing groups. Thermodilution cardiac output was measured in vivo at baseline and after a fluid load. Basal cardiac output and peak cardiac output achieved by increased preload were measured in vitro in the working heart mode. Results: The mean ejection fractions in the doxorubicin-treated and ligation groups were significantly (P < 0.001) lower than in controls, but there was wide inter-individual variability ranging from normal to severely impaired function [mean ± s.d. (range) controls 0.65 ± 0.03 (0.59-0.72), doxorubicin 0.45 ± 0.11 (0.30-0.67), ligation 0.42 ± 0.12 (0.25-0.65)]. Basal and peak cardiac outputs in vivo and in vitro were significantly lower in the doxorubicin and coronary ligation groups than in controls, although there was a wider scatter of values in the pathological groups. Among the doxorubicin and coronary ligation groups, hearts with ejection fractions <-0.40 demonstrated significantly impaired haemodynamic function compared with those with ejection fractions > 0.40. There were significant correlations between ejection fraction and all indices of haemodynamic function in vivo and in vitro. Conclusions: Simple non-invasive measurement of ejection fraction allowed improved characterization of haemodynamic responses in vivo and in vitro. Individual assessment of animals by echocardiography will improve interpretation of cellular or molecular studies in experimental heart failure by relating observed abnormalities to the degree of global cardiac dysfunction.
8-Hydroxydeoxyguanosine in urine as an index of oxidative damage to DNA in the evaluation of atopic dermatitis
Authors: None Tsuboi, None Kouda, None Takeuchi, None Takigawa, None Masamoto, None Takeuchi, None Ochi
Journal: British Journal of Dermatology (1998)

8-hydroxydeoxyguanosine (8-OHdG) is one of the products which are excreted in urine as a result of oxidative damage to DNA. We investigated the feasibility of using 8-OHdG in urine as an index for oxidative damage to DNA in atopic dermatitis (AD). Seventeen patients with long-standing AD and 17 healthy volunteers were enrolled in this study. The severity of AD was evaluated by SCORAD index. Eosinophils, total IgE and lactate dehydrogenase-5 in peripheral blood were measured as clinical parameters for AD. A newly developed enzyme-linked immunosorbent assay method was used to measure urine 8-OHdG. The AD patients showed significantly higher levels (P < 0.0001) of 8-OHdG in their urine than corresponding controls. Urine 8-OHdG levels showed as strong a positive correlation as other haematological parameters did using the SCORAD index. Thus, we conclude that the urine 8-OHdG levels can also serve as a biochemical index of tissue damage and can act as a useful tool in the clinical evaluation of AD.
Coronary vascular reserve in the greyhound with left ventricular hypertrophy
Authors: M. V COHEN
Journal: Cardiovascular Research (1986)

Journal Article Coronary vascular reserve in the greyhound with left ventricular hypertrophy Get access MICHAEL V COHEN MICHAEL V COHEN From the Division of Cardiology, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, New York, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 3, March 1986, Pages 182–194, https://doi.org/10.1093/cvr/20.3.182 Published: 01 March 1986
“Drink plenty of fluids”:No harm in fluids for colds and flu
Authors: Ronald Eccles, Martez Jawad
Journal: BMJ (2004)

EDITOR—The article by Guppy et al as a systematic review of evidence for the effects of fluid intake1 on the course of acute respiratory infections has been interpreted in the press as a warning against fluid intake while suffering from infections of the acute upper respiratory tract, such as …
1022-84 Survival benefits of primary angioplasty over thrombolysis after adjustment for percutaneous transluminal coronary angioplasty related time delay
Authors: Giuseppe Tarantini, Angelo Ramondo, Massimo Napodano, Paolo Buja, Giambattista Isabella, Claudio Bilato, Renato Razzolini, Sabino Iliceto
Journal: Journal of the American College of Cardiology (2004)
Typhoid fever and other salmonella infections.
Authors: J. H. Means
Journal: JAMA (1963)

Many people, including a great many doctors, labor under the delusion that typhoid fever is extinct. Far from it. Throughout the world, in the less developed countries, typhoid is endemic. Hundreds of thousands of cases occur each year. In Europe and North America it also appears in the form of occasional and scattered epidemics started chiefly by carriers.  Mr. Huckstep had the opportunity to care for and study some 1,300 patients with typhoid fever while serving in Kenya, East Africa, from 1954 to 1961. He has analyzed their cases for our benefit. The result is a comprehensive textbook, the excellence of which this reviewer can fully appreciate because of experience with typhoid which he had himself at the beginning of the century.  The classical features of typhoid and the other salmonella diseases are described accurately and succinctly, both in their clinical and laboratory aspects. The sanitary and epidemiological aspects are
FOREIGN BODY IN THE BREAST
Authors: FRANKLIN G. BALCH
Journal: JAMA (1949)

The observation of foreign bodies in the breast is extremely rare. The following case is of particular interest in as much as it offers an unusual problem in the differential diagnosis of tumors of the breast. <h3>REPORT OF CASE</h3> The patient was a housewife aged 38 who had always been in good health with a normal appetite and normal bowel habits. Her menses had been a little irregular for the past eight months. Her husband and three children were living and well. The youngest child was 6 years of age. The patient had nursed the first two children. Her mother died of carcinoma of the breast at 64 years of age, her father of carcinoma of the prostate at 73. About four weeks before the patient sought medical aid, she felt some discomfort in the right breast and found a lump beneath the nipple. This had not grown in size
Trauma Anesthesia and Intensive Care
Authors: Edward K. McGough
Journal: JAMA (1991)

In the preface, the editors state that this textbook is designed as a comprehensive summary for the anesthetic and general management of the injured patient. Overall, the book does provide a complete text for the practicing anesthesiologist who deals with trauma patients. However, some areas of the text cover many surgical aspects of trauma in excessive detail. The first section of the book, "Basic Considerations," deals with principles that apply to all types of trauma patients. The first two chapters provide the epidemiology of trauma and considerations in the establishment of care priorities in the emergency department. These areas of trauma care are usually not included in most anesthesia textbooks. The third chapter, "Airway Management," deals with the difficult problem of managing the traumatized airway. It presents both simple and complex airway management problems and includes most of the techniques and special tricks known in anesthesia. There are excellent diagrams
NAHAT calls for more GP training
Authors: C Court
Journal: BMJ (1994)

General practitioners need updated training and continuing education if they are to meet the challenges of expanded primary health care and the advances in medical technology, says the National Association of Health Authorities and Trusts (NAHAT). The association wants the training period for principals in general practice to be increased to five years: a three year period of general professional (vocational) training for all doctors in general practice followed by a …
Children of Immigrants May Face Stresses, Challenges That Affect Mental Health
Authors: Lynne Lamberg
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rat lung contains a developmentally regulated manganese superoxide dismutase mRNA-binding protein.
Authors: H Fazzone, A Wangner, L B Clerch
Journal: Journal of Clinical Investigation (1993)

It has become increasingly clear that RNA-binding proteins play an important role in the regulation of gene expression. The presence in rat lung of a specific, redox-sensitive catalase RNA-binding protein was recently reported (Clerch, L. B., and D. Massaro, 1992. J. Biol. Chem. 267:2853). In order to determine if specific manganese superoxide dismutase (MnSOD) RNA-binding proteins exist, we tested whether protein in rat lung extract would bind to 32P-labeled MnSOD RNA. Using a gel mobility shift assay we show rat lung protein forms specific complexes with a 216 b fragment of the 3' untranslated region of MnSOD RNA and the binding requires the presence of free sulfhydryl groups. Competition studies indicate MnSOD RNA-binding protein is different from catalase RNA-binding protein. Furthermore, unlike catalase RNA-binding protein, rat lung MnSOD RNA-binding protein activity is developmentally regulated; there is less MnSOD RNA-protein binding activity in adult rat lung extract compared to prenatal or neonatal rat lung extracts. We conclude the lung contains developmentally regulated MnSOD mRNA-binding protein that is redox sensitive.
306 Apoptosis and HCV: an un-solved phenomena
Authors: A.N. Zekri, A.A. Bahnassy, A.M. El-Shahaby, N. El-Guendy, M. Mohamed Hafez, S. Radwn, H. El-Leathey, S.A. Abdel-Wahab, H.M. Khaled
Journal: Journal of Hepatology (2006)
Spliced Spleen Necrosis Virus Vector RNA Is Not Encapsidated: Implications for Retroviral Replication and Vector Design
Authors: Adrienne Goodrich, Zahida Parveen, Ralph Dornburg, Matthias J Schnell, Roger J Pomerantz
Journal: Molecular Therapy (2004)

RNA splicing is a complex event in the retroviral life cycle and can involve multiple steps, as well as cis-acting sequences, to maintain a proper balance of spliced and unspliced viral RNA for translation and encapsidation. The retroviral RNA can be processed by cellular machinery and enables the removal of intronic sequences. We aimed to utilize the removal of a synthetic intron for targeted gene expression. To analyze intron removal and gene expression, we have constructed a novel self-inactivating gene-activating (SIGA) vector for potential universal gene therapy. New vectors for gene therapy are necessary for safe and effective gene delivery in humans. The SIGA vector is derived from spleen necrosis virus (SNV), which is an avian reticuloendotheliosis virus. The vector was designed so that expression of a therapeutic gene is blocked in helper cell lines due to an intervening sequence containing various blocks in transcription and translation. However, after one round of retroviral replication, the intervening sequence should be removed by the cellular machinery and the therapeutic gene will be selectively expressed in target cells. Our studies show that the intervening sequence in SIGA vector RNA is partially spliced. However, spliced vector RNA was not transduced to target cells. Previous studies showed that an infectious SNV vector enabled transduction of spliced RNA. However, yet-undefined differences in infectious and replication-deficient retroviral replication may have an effect on the transduction of spliced RNA. The results of this study present key information on spliced RNA and its encapsidation, as well as data for the construction of a new generation of SNV-derived retroviral vectors.
987-102 Proximal Flow Convergence Calculation of Forward Flow and Valve Area of Normal Mitral Prostheses: An Intraoperative Validation
Authors: Dominic Y. Leung, Pieter M. Vandervoort, Neil L. Greenberg, Leonardo Rodriguez, Min Pu, William J. Stewart, James D. Thomas
Journal: Journal of the American College of Cardiology (1995)
Altered kinetic properties of the branched-chain alpha-keto acid dehydrogenase complex due to mutation of the beta-subunit of the branched-chain alpha-keto acid decarboxylase (E1) component in lymphoblastoid cells derived from patients with maple syrup urine disease.
Authors: Y Indo, A Kitano, F Endo, I Akaboshi, I Matsuda
Journal: Journal of Clinical Investigation (1987)

Branched-chain alpha-keto acid dehydrogenase (BCKDH) complexes of lymphoblastoid cell lines derived from patients with classical maple syrup urine disease (MSUD) phenotypes were studied in terms of their catalytic functions and analyzed by immunoblotting, using affinity purified anti-bovine BCKDH antibody. Kinetic studies on three cell lines derived from patients with the classical phenotype showed sigmoidal or near sigmoidal kinetics for overall BCKDH activity and a deficiency of the E1 component activity. An immunoblot study revealed a markedly decreased amount of the E1 beta subunit accompanied by weak staining of the E1 alpha subunit. The E2 and E3 component exhibited a cross-reactive peptide. Thus, in at least some patients with MSUD, mutations of the E1 beta subunit might provide an explanation for the altered kinetic properties of the BCKDH complex.
Health Care of House Officers
Authors: Ronald J. Heller, Leon S. Robertson, Joel J. Alpert
Journal: New England Journal of Medicine (1967)

THE delivery of quality medical care is a worthy goal of current social and political planners. Certainly, physicians and their families ought to be receiving the ultimate in medical care. Yet some reports have suggested that physicians do not receive what can be called basic medical care. Perhaps the custom of professional courtesy interferes with rather than assists in the delivery of care to the physician and his family,1 2 3 as suggested by the fact that more abnormalities are detected than visually anticipated when annvial physical examinations and screening procedures are performed at medical meetings.4 Since the patterns of care of . . .