tbuckley/cabot-search huggingface dataset:
Pityriasis lichenoides chronica resolving after tonsillectomy
Authors: K. Takahashi, M. Atsumi
Journal: British Journal of Dermatology (1993)

British Journal of DermatologyVolume 129, Issue 3 p. 353-354 Pityriasis lichenoides chronica resolving after tonsillectomy K. Takahashi, K. Takahashi Department of Dermatology, Tohoku Rosai Hospital. 4-3-21 Dainohara, Aoba-Ku Sendai 981. JapanSearch for more papers by this authorM. Atsumi, M. Atsumi Department of Dermatology, Tohoku Rosai Hospital. 4-3-21 Dainohara, Aoba-Ku Sendai 981. JapanSearch for more papers by this author K. Takahashi, K. Takahashi Department of Dermatology, Tohoku Rosai Hospital. 4-3-21 Dainohara, Aoba-Ku Sendai 981. JapanSearch for more papers by this authorM. Atsumi, M. Atsumi Department of Dermatology, Tohoku Rosai Hospital. 4-3-21 Dainohara, Aoba-Ku Sendai 981. JapanSearch for more papers by this author First published: September 1993 https://doi.org/10.1111/j.1365-2133.1993.tb11872.xCitations: 17AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume129, Issue3September 1993Pages 353-354 RelatedInformation
Medicine and Culture: Varieties of Treatment in the United States, England, West Germany, and France
Authors: Odin W. Anderson
Journal: JAMA (1989)

This book by a medical journalist with medical science—related training in biochemistry helps to put medical practice in a cross-national framework by comparing practice in four countries: the United States, Great Britain, France, and West Germany. The author is an American and has also lived in the other countries for quite a few years; she is fluent in French and German. She is modest in her claims of competence in writing this lively book in that she is a journalist and not a social scientist. Good journalists, however, and she is obviously one, have a nose for descriptive vignettes that give some glimmers of their context, and that provide more systematically oriented and trained researchers some handles by which to formulate hypotheses to test. Payer gathered information and impressions by interviewing many physicians in these four countries and gathering published data on surgical rates, drug consumption, and so on. Given
Comparative Effects of Tissue Plasminogen Activator, Streptokinase, and Staphylokinase on Cerebral Ischemic Infarction and Pulmonary Clot Lysis in Hamster Models
Authors: N. Nagai, I. Vanlinthout, D. Collen
Journal: Circulation (1999)

Background —The effects of alteplase (rtPA), streptokinase, and staphylokinase (rSak) on focal cerebral ischemia (FCI) and on pulmonary clot lysis (PCL) were studied in hamsters. Methods and Results —FCI was produced by ligation of the left middle cerebral artery (MCA) and common carotid artery (CCA) and a 10-minute occlusion of the right CCA. FCI was measured after 24 hours by 2,3,5-triphenyltetrazolium chloride staining. 125 I-fibrin–labeled plasma clots were injected via the jugular vein, and clot lysis was determined from residual radioactivity at 90 minutes. Study drugs were given intravenously over 60 minutes. FCI increased from 1.2 (0.27 to 2.3) mm 3 (median and 17th to 83rd percentile range, n=24) in controls to 19 to 27 mm 3 with thrombolytic agent, with maximal rates at 0.13±0.05 mg/kg rtPA, 0.23±0.09 mg/kg streptokinase, and 0.037±0.025 mg/kg rSak. PCL increased from 18±2% (mean±SEM, n=27) in controls to ≈85% with thrombolytics, with maximal rates at 0.12±0.03 mg/kg rtPA, 0.17±0.05 mg/kg streptokinase, and 0.018±0.002 mg/kg rSak. All agents caused maximal FCI and PCL rates at similar doses without α 2 -antiplasmin and fibrinogen depletion. Injection of 6 mg/kg human plasminogen combined with streptokinase caused a “systemic fibrinolytic state” with fibrinogen depletion. Maximal rates of FCI were obtained with 0.097±0.077 mg/kg streptokinase ( P =0.26 versus streptokinase alone) and of PCL with 0.010±0.002 mg/kg ( P =0.006 versus streptokinase alone). Conclusions —Thrombolytic agents cause similar dose-related extension of FCI after MCA ligation and PCL, irrespective of the agent or systemic plasmin generation.
Radioimmunoassay of human plasma retinol-binding protein
Authors: Frank Rees Smith, Amiram Raz, DeWitt S. Goodman
Journal: Journal of Clinical Investigation (1970)

A radioimmunoassay for human plasma retinol-binding protein (RBP) has been developed utilizing a double antibody precipitation technique. RBP was purified 1500- to 2000-fold by procedures described previously. A specific anti-human RBP antiserum was prepared in rabbits by three once-weekly injections of purified RBP emulsified with Freund's adjuvant. RBP was iodinated with 131I and the RBP-131I was purified by gel filtration on Sephadex G-100 after complex formation with human plasma prealbumin. The RBP-131I was completely (> 95%) immunoprecipitable in the presence of an excess of specific antiserum, it was not (< 5%) immunoprecipitable in the absence of specific antiserum, and it could be completely displaced from antibody by excess unlabeled RBP. The standard curve obtained in the immunoassay with normal plasma was identical to that with pure RBP. Duplicate samples differed from their mean by 5 ±5% (±SD). There was a quantitative recovery of pure RBP added in varying amounts to normal plasma. The immunoassay accurately measured RBP in amounts of 10-100 ng per assay tube. There was no significant difference in the immunoreactivity of apo-RBP as compared to holo-RBP. The mean plasma values (±SEM) for a group of 76 normal subjects were 47.2 ±1.6 μg/ml for males and 41.6 ±1.6 μg/ml for females. Plasma RBP levels were markedly depressed (15 ±2.3 μg/ml) in 14 patients with acute viral hepatitis. There was a highly significant correlation between the plasma levels of RBP and of vitamin A in both normal subjects and patients with hepatitis. In all subjects plasma RBP was generally saturated with retinol. The data suggest that under normal circumstances RBP circulates almost exclusively as the holoprotein.
Baseline Q-Wave Surpasses Time From Symptom Onset as a Prognostic Marker in ST-Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention
Authors: Paul W. Armstrong, Yuling Fu, Cynthia M. Westerhout, Michael P. Hudson, Kenneth W. Mahaffey, Harvey D. White, Thomas G. Todaro, Peter X. Adams, Philip E.G. Aylward, Christopher B. Granger
Journal: Journal of the American College of Cardiology (2009)
Extracellular idiotypic immunoglobulin arising from human leukemic B lymphocytes.
Authors: F K Stevenson, T J Hamblin, G T Stevenson, A L Tutt
Journal: The Journal of Experimental Medicine (1980)

The peripheral blood lymphocytes of nine out of nine patients with typical surface Ig-positive chronic lymphocytic leukemia but no paraprotein visible on serum electrophoresis have been shown by radioimmunoassay to export small amounts of pentameric IgM during culture (in the range of 2.4-7.2 ng/10(7) cells per h); three out of nine also exported monomeric IgD (0.7-1.4 ng/10(7) cells per h). Immunoglobulin turned over on the cell surface did not appear to contribute to material in the culture fluid, except possibly as vesicle-bound Ig. In three cases, which included two of the IgD producers, anti-idiotypic antibody raised against the cell surface Fab mu was used to demonstrate the idiotypic nature of the exported Ig. Anti-idiotypic antibody was also used to measure levels of idiotypic Ig in the sera of these three patients as a proportion of the total Ig. Total serum IgM was depressed in all three patients, and the idiotypic IgM represented 43%, 65%, and 96% of the IgM. The findings suggest that in typical chronic lymphocytic leukemia involving B lymphocytes, the export of a small amount of idiotypic Ig by the neoplastic cells in a common or even usual occurrence.
Immunotargeting of tumor vasculature: preclinical development of novel antibody-based imaging and therapy against TEM1/CD248
Authors: Chunsheng Li, Junying Wang, Jia Hu, Ann Marie Chacko, Aizhi Zhao, Chaitanya Divgi, Vladimir Muzykantov, George Coukos
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts The success of antibody-based theranostics depends on the identification of tumor specific biomarkers and the development of corresponding antibodies with high-affinity and specificity. Tumor endothelial marker-1 (TEM1) is highly expressed in tumor vasculature of multiple cancers
FURTHER OBSERVATIONS ON CERTAIN FEATURES OF EXPERIMENTAL SYPHILIS AND YAWS IN THE RABBIT
Authors: Henry J. Nichols
Journal: The Journal of Experimental Medicine (1911)

1. Lesions of the testicle and scrotum of the rabbit produced by the treponema of syphilis and of yaws afford material for the study of chemotherapy, of serum reactions, and of immunity. 2. On experimental and clinical grounds, it appears that yaws can be cured with a smaller dose of salvarsan than is necessary to cure syphilis. 3. The spirochaetae of syphilis do not become resistant after repeated treatments with salvarsan. 4. Sodium cacodylate has little effect on the treponema of either disease. 5. Mercury, in a single intravenous dose, has a spirillicidal effect, but the necessary dose usually causes the death of the animal later from nephritis. 6. Potassium iodid, in a single intravenous dose, has no spirillicidal effect. 7. The complement fixation reaction is closely correlated with the course of an infection, as is shown by its onset and its disappearance after castration or treatment. 8. Reinfection during the course of a testicular lesion does not occur, but it occurs after regression, treatment, or extirpation. 9. Specific differences between Treponema pallidum and Trepanema pertenue can be demonstrated in infected animals treated with salvarsan and reinoculated.
A COMPARISON OF THE PHARMACOLOGIC ACTIVITY OF THE FLUID EXTRACT OF SQUILL PREPARED ACCORDING TO THE UNITED STATES PHARMACOPEIA 1890 AND 1900.
Authors: E. M. HOUGHTON
Journal: JAMA (1906)

work, it was 151; in 1902, 77; in 1903, about 50, and it has remained since that date at about 40.I consider that for a city the size of Havana this means the practical extermination of the disease, as that num- ber of cases in the .ordinarycourse of events would be brought in from the outside, or be due to mistakes in diagnosis.Panama, I suppose, is as favorable a place for the development of malaria as could be found.The towns of Colon and Panama, at the termini of the canal, are not large enough to do away with the breeding of ano- pheles; that is, anopheles breeding in the suburbs can very well travel to the centers of these towns, and the population living along the canal in little villages a mile or two apart, between Colon and Panama, are
A Retrospective Study of Blind Diabetic Patients
Authors: Joseph W. Berkow
Journal: JAMA (1965)

Review of a series of 180 blind diabetic patients who had received guide dogs from the Seeing Eye, Inc., over a 17-year period included 85 deceased and 95 living diabetic patients. The average age at onset of diabetes in the entire group was 14.6 years, and the mean age at onset of severe blindness was 31.4 years. Each group of diabetic patients, the living and the deceased, had used its guide dogs an average of 3.5 years. Of the 85 deceased diabetics in this series, the average lifespan after the onset of severe blindness due to diabetic retinopathy was 5.8 years. This suggests that the life expectancy of a diabetic is very poor after the onset of blindness due to severe retinopathy.
Decreased concentration of myofibrils and myofiber hypertrophy are structural determinants of impaired left ventricular function in patients with chronic heart diseases: A multiple logistic regression analysis
Authors: Gisela Zimmer, Rainer Zimmermann, Otto M. Hess, Jakob Schneider, Wolfgang Kübler, Hans Peter Krayenbuehl, Siegfried Hagl, Gerhard Mall
Journal: Journal of the American College of Cardiology (1992)
Left ventricular compliance in acute myocardial infarction in man
Authors: J. BARDET, P. ROCHA, M. RIGAUD, J. P. BOURDARIAS, A. MATHIVAT
Journal: Cardiovascular Research (1977)

Journal Article Left ventricular compliance in acute myocardial infarction in man Get access J. BARDET, J. BARDET From the Department of Cardiology, Hopital Amhroise Paré, Universite René Descartes, Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar P. ROCHA, P. ROCHA From the Department of Cardiology, Hopital Amhroise Paré, Universite René Descartes, Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar M. RIGAUD, M. RIGAUD From the Department of Cardiology, Hopital Amhroise Paré, Universite René Descartes, Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar J. P. BOURDARIAS, J. P. BOURDARIAS From the Department of Cardiology, Hopital Amhroise Paré, Universite René Descartes, Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar A. MATHIVAT A. MATHIVAT From the Department of Cardiology, Hopital Amhroise Paré, Universite René Descartes, Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 11, Issue 2, March 1977, Pages 122–131, https://doi.org/10.1093/cvr/11.2.122 Published: 01 March 1977
Spring Books: A tapestry of time warps
Authors: W R Lee
Journal: BMJ (1986)

An important early lesson in science is that a thermometer, whether inserted into a liquid or a human being, registers only its own temperature.Similarly, the reader ofa book on social history such as Medicine and Industrial Society, with its explanatory subtitle "A History of Hospital Development in Manchester and its Region, 1752Region, -1946," ," should remember that the story is being unfolded and interpreted by one man.
Comparison of Anterior, Posterior, Left Anterior Oblique and Geometric Mean Gastric Emptying Using Glucose Solutions
Authors: M. R. Blumhardt, W. T. Phillips, J. S. Schwartz, C. A. McMahan, R. Blumhardt
Journal: Clinical Nuclear Medicine (1993)

Blumhardt, M. R.; Phillips, W. T.; Schwartz, J. S.; McMahan, C. A.; Blumhardt, R. Author Information
Can Bruits Distinguish High-Grade from Moderate Symptomatic Carotid Stenosis?
Authors: J. Stephane Sauve
Journal: Annals of Internal Medicine (1994)

Objective: To determine whether cervical bruits, alone or combined with other clinical characteristics, can distinguish high-grade (70% to 99%) carotid artery stenoses from less severe stenoses in patients with symptoms of cerebrovascular disease. Design: Cross-sectional comparison of clinical observations with contemporaneous angiography. Setting: The North American Symptomatic Carotid Endarterectomy Trial (NASCET), a multicenter randomized, controlled trial of carotid endarterectomy. Patients: All patients enrolled in the NASCET from its inception in 1988 to November 1991. Results: A focal ipsilateral carotid bruit had a sensitivity of 63% and a specificity of 61% for high-grade stenosis and, when absent, only lowered the probability for high-grade stenosis from a pretest value of 52% to a post-test probability of 40%. When combined with four other clinical characteristics (an infarction on computed tomography of the head, a carotid ultrasound scan suggesting more than 90% stenosis, a transient ischemic attack rather than a minor stroke as a qualifying event, and a retinal rather than a hemispheric qualifying event), the predicted probabilities of high-grade stenosis ranged from a low of 18% (when none of the features was present) to a high of 94% (when all the features were present). Conclusions: Cervical bruits alone were not sufficiently predictive of high-grade symptomatic carotid stenosis to be useful in selecting patients for angiography; they were absent in over one third of patients with high-grade stenosis. When combined with other clinical variables, patients with high or low probabilities of 70% to 99% stenoses could be identified, but this prediction model still missed many individuals with high-grade stenosis, even in this training set of selected patients.
Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury
Authors: Noémi K. M. Van Hul, Jorge Abarca-Quinones, Christine Sempoux, Yves Horsmans, Isabelle A. Leclercq
Journal: Hepatology (2009)

In chronic liver injury, liver progenitor cells (LPCs) proliferate in the periportal area, migrate inside the lobule, and undergo further differentiation. This process is associated with extracellular matrix (ECM) remodeling. We analyzed LPC expansion and matrix accumulation in a choline-deficient, ethionine-supplemented (CDE) model of LPC proliferation. After day 3, CDE induced collagen deposits in the periportal area. Expansion of LPCs as assessed by increased number of cytokeratin 19 (CK19)-positive cells was first observed at day 7, while ECM accumulated 10 times more than in controls. Thereafter, LPCs and ECM increased in parallel. Furthermore, ECM not only accumulates prior to the increase in number of LPCs, but is also found in front of LPCs along the porto-venous gradient of lobular invasion. Double immunostaining revealed that LPCs are embedded in ECM at all times. Moreover, LPCs infiltrating the liver parenchyma are chaperoned by alpha-smooth muscle actin (alpha-SMA)-positive cells. Gene expression analyses confirmed these observations. The expression of CK19, alpha-fetoprotein, E-cadherin, and CD49f messenger RNA (mRNA), largely overexpressed by LPCs, significantly increased between day 7 and day 10. By contrast, at day 3 there was a rapid burst in the expression of components of the ECM, collagen I and laminin, as well as in alpha-SMA and connective tissue growth factor expression.Our data demonstrate that, in a CDE model, ECM deposition and activation of matrix-producing cells occurred as an initial phase, prior to LPC expansion, and in front of LPCs along the porto-venous gradient of lobular invasion. Those observations may reveal a fundamental role for the established hepatic microenvironment or niche during the process of activation and differentiation of liver progenitor cells.
New test simplifies genetic testing for breast cancer
Authors: X. Bosch
Journal: BMJ (2002)

Mortality associated with breast cancer has decreased by 25% over the past decade, Josep Baselga, head of the oncology unit of the Hospital Vall d'Hebron in Barcelona, told the third European breast cancer conference last week.

In addition to the introduction of new drugs, a leading cause for such reduction was the progressive expansion of screening programmes, he told delegates at the conference in Barcelona, attended by more than 4000 specialists.

The conference also heard from the United Kingdom's Nottingham Research Unit about a new test to detect …
The effect of a peptide-modified thermo-reversible methylcellulose on wound healing and LV function in a chronic myocardial infarction rodent model
Authors: Shirley S. Mihardja, Jose A. Gonzales, Dongwei Gao, Richard E. Sievers, Qizhi Fang, Carol A. Stillson, Jiashing Yu, Michelle Peng, Randall J. Lee
Journal: Biomaterials (2013)
Adrenergic receptor control mechanism for growth hormone secretion
Authors: William G. Blackard, Sylvia A. Heidingsfelder
Journal: Journal of Clinical Investigation (1968)

The influence of catecholamines on growth hormone secretion has been difficult to establish previously, possibly because of the suppressive effect of the induced hyperglycemia on growth hormone concentrations. In this study, an adrenergic receptor control mechanism for human growth hormone (HGH) secretion was uncovered by studying the effects of alpha and beta receptor blockade on insulin-induced growth hormone elevations in volunteer subjects. Alpha adrenergic blockade with phentolamine during insulin hypoglycemia, 0.1 U/kg, inhibited growth hormon elevations to 30-50% of values in the same subjects during insulin hypoglycemia without adrenergic blockade. More complete inhibition by phentolamine could not be demonstrated at a lower dose of insulin (0.05 U/kg). Beta adrenergic blockade with propranolol during insulin hypoglycemia significantly enhanced HGH concentrations in paired experiments. The inhibiting effect of alpha adrenergic receptor blockade on HGH concentrations could not be attributed to differences in blood glucose or free fatty acid values; however, more prolonged hypoglycemia and lower plasma free fatty acid values may have been a factor in the greater HGH concentrations observed during beta blockade. In the absence of insulin induced hypoglycemia, neither alpha nor beta adrenergic receptor blockade had a detectable effect on HGH concentrations. Theophylline, an inhibitor of cyclic 3'5'-AMP phosphodiesterase activity, also failed to alter plasma HGH concentrations. These studies demonstrate a stimulatory effect of alpha receptors and a possible inhibitory effect of beta receptors on growth hormone secretion.
Resistance of erythrocytes to lipid peroxidation in alcoholic patients.
Authors: N A Punchard, H Senturk, J P Teare, R P Thompson
Journal: Gut (1994)

The ability of erythrocytes to resist lipid peroxidation may be a useful marker of antioxidant status in alcoholic patients, in whom depletion of dietary antioxidants may combine with increased production of free radicals to produce liver damage. There are conflicting reports, however, on the resistance of erythrocytes from alcoholic patients to lipid peroxidation. This study examined the relation between the degree of alcohol induced liver disease and the resistance of erythrocytes to chemically induced lipid peroxidation, measuring lipid peroxidation as malondialdehyde production. Erythrocytes from alcoholic patients with Child9s C cirrhosis had significantly increased resistance to lipid peroxidation compared with both controls (p &lt; 0.001) and alcoholic patients with moderate liver disease (p &lt; 0.001). There was no difference between alcoholic patients with moderate liver disease and controls. Increased resistance to free radical initiated lipid peroxidation in alcoholic patients is related to liver damage rather than to alcohol abuse alone. This could arise from changes in the lipid composition of the erythrocyte membranes resulting from abnormal liver function. Tests of antioxidant status based upon the resistance of erythrocytes to free radical stress in vitro may therefore be flawed when such changes in membrane lipid composition can occur.
Anencephalic Infants as Organ Donors
Authors: Jamil H. Khan
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The AMA Council on Ethical and Judicial Affairs<sup>1</sup>has changed its previous position and now supports the use of live anencephalic infants as organ donors. However, in their report, fundamental issues relating to the definition of personhood and even the definition of life and death are not adequately addressed. In undermining the "dead donor"<sup>2</sup>rule, the report seems to be arguing for "cortical death"—the absence of higher brain function as a new definition of death—without overtly stating this point. A circumstance in which higher brain function is not present and will never be possible is the defining feature of the reasoning used by the Council. This fundamental change in defining life and death needs open discussion and a broad-based consensus before being adopted. Other clinical situations occur in which an argument can be made for organ procurement from a living donor. A severely asphyxiated neonate