tbuckley/cabot-search huggingface dataset:
Correspondence Course: Tips for Getting a Letter Published in &lt;emph type="ital"&gt;JAMA&lt;/emph&gt;
Authors: Robert M. Golub
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical implications of the stress response.
Authors: G Minowada, W J Welch
Journal: Journal of Clinical Investigation (1995)

A field of research that began with a curious observation in Drosophila has resulted in a new understanding of how cells respond to sudden and adverse changes in their environment. In addition through the study of the structure/function of the stress proteins, especially those which function as molecular chaperones, new insights into the details by which proteins are synthesized and acquire their final biologically active conformation have been realized. Equally exciting is the progress being made as it relates the potential diagnostic and therapeutic applications of the stress-response proteins. The use of stress proteins as the next generation of vaccines and/or their use as potentially powerful adjuvants, capable of stimulating both T and B cell responses to a particular antigen of interest appear close to becoming a reality. One wonders how many more surprises are in store for us as we continue to explore this evolutionally conserved cellular stress response.
SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR IS AN INDEPENDENT PREDICTOR OF CARDIOVASCULAR OUTCOMES IN PATIENTS WITH LEFT VENTRICULAR SYSTOLIC DYSFUNCTION
Authors: Nima Ghasemzadeh, Danny Eapen, Ayman Samman Tahhan, Hatem Al Kassem, Mohamed Khayata, Pankaj Manocha, Zahi Merjaneh, Ravi P. Avati Nanjundappa, Maan M. Malahfji, Kiran Valiani, Ibhar Al Mheid, Vijay A. Reddy, Tomasz Pielak, Christian W. Thorball, Riyaz Patel, Laurence Sperling, Stamatios Lerakis, Arshed Quyyumi
Journal: Journal of the American College of Cardiology (2013)
Review: NSAIDs increase GI and CV events; coxibs increase mortality
Authors: Ellis Lader
Journal: Annals of Internal Medicine (2013)

Source Citation Coxib and traditional NSAID Trialists' (CNT) Collaboration. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013;382:769-79. 23726390
Is the Bituminous Coal Miner Immune from Tubercular Infection While Actively Engaged in His Occupation?
Authors: M. C. Carr
Journal: JAMA (1905)

DuQuoin, Ill., Nov. 21, 1905. <h3>To the Editor:</h3> —After an experience of 25 years in one of the largest coal mining towns in southern Illinois, and during this time having under my observation from 700 to 1,200 coal miners; and after careful enquiry among the oldest miners in this locality as to the number of coal miners that have been infected with this dreadful disease, I have been forced to the conclusion that bituminous coal miners, while actively engaged in their occupation, are practically immune from tubercular infection. About seven years ago I commenced the treatment of whooping cough by sending the patient down in the mines immediately after the miners had fired a shot; having the patient inhale the gas and powder smoke for one and a half to two hours at a time. I found that one or two sittings was sufficient to effect a cure in from
Quality of Care for Patients With Rheumatoid Arthritis
Authors: Catherine H. MacLean
Journal: JAMA (2000)

Patients with rheumatoid arthritis are at risk for substantial morbidity because of their arthritis and premature mortality due to comorbid diseases. However, little is known about the quality of the health care that these patients receive.To assess the quality of the health care that rheumatoid arthritis patients receive for their arthritis, comorbid diseases, and health care maintenance and to determine the effect of patterns of specialty care on quality.Historical cohort study of 1355 adult rheumatoid arthritis patients enrolled in the fee-for-service or discounted fee-for-service plans of a nationwide US insurance company. Patients were identified and followed up through administrative data between 1991 and 1995.Quality scores for arthritis, comorbid disease, and health care maintenance were developed from performance on explicit process measures that related to each of these domains and described the percentage of indicated health care processes performed within each domain during each person-year of the study.During 4598 person-years of follow-up, quality scores were 62% (95% confidence interval [CI], 61%-64%) for arthritis care, 52% (95% CI, 49%-55%) for comorbid disease care, and 42% (95% CI, 40%-43%) for health care maintenance. Across domains, care patterns including relevant specialists yielded performance scores 30% to 187% higher than those that did not (P<.001) and 45% to 67% of person-years were associated with patterns of care that did not include a relevant specialist. Presence of primary care without specialty care yielded health care maintenance scores that were 43% higher than those for patterns that included neither primary nor relevant specialty care (P<.001).In this population, health care quality appears to be suboptimal for arthritis, comorbid disease, and health care maintenance. Patterns of care that included relevant specialists were associated with substantially higher quality across all domains. Patterns that included generalists were associated with substantially higher quality health care maintenance than patterns that included neither a generalist nor a relevant specialist. The optimal roles of primary care physicians and specialists in the care of patients with complex conditions should be reassessed. JAMA. 2000;284:984-992
Disruption to NHS could force doctors and managers to operate more sustainably, conference is told
Authors: M. Limb
Journal: BMJ (2012)

The NHS in England can take advantage of the health reforms to finally live within its means for the good of society and the environment, a conference on sustainable healthcare has heard.

David Pencheon, director of the NHS’s Sustainable Development Unit, said that the transition to new structures under the Health and Social Care Act was an opportunity “too good to waste.” He said that it would allow new organisations, such as clinical commissioning groups and health and wellbeing boards, to plan to operate sustainably and to use resources more effectively from the outset.

“Transitions, though destabilising, can be a very fertile time and provide a chance for more innovative thinking,” he said.

But he acknowledged that much still needed to …
NARRATION
Authors: Henry F. Howe
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Examining urban brownfields through the public health "macroscope".
Authors: Jill S Litt, Nga L Tran, Thomas A Burke
Journal: Environmental Health Perspectives (2002)

Efforts to cope with the legacy of our industrial cities--blight, poverty, environmental degradation, ailing communities--have galvanized action across the public and private sectors to move vacant industrial land, also referred to as brownfields, to productive use; to curb sprawling development outside urban areas; and to reinvigorate urban communities. Such efforts, however, may be proceeding without thorough investigations into the environmental health and safety risks associated with industrial brownfields properties and the needs of affected neighborhoods. We describe an approach to characterize vacant and underused industrial and commercial properties in Southeast Baltimore and the health and well being of communities living near these properties. The screening algorithm developed to score and rank properties in Southeast Baltimore (n= 182) showed that these sites are not benign. The historical data revealed a range of hazardous operations, including metal smelting, oil refining, warehousing, and transportation, as well as paints, plastics, and metals manufacturing. The data also identified hazardous substances linked to these properties, including heavy metals, solvents, polycyclic aromatic hydrocarbons, plasticizers, and insecticides, all of which are suspected or recognized toxicants and many of which are persistent in the environment. The health analysis revealed disparities across Southeast Baltimore communities, including excess deaths from respiratory illness (lung cancer, chronic obstructive pulmonary disease, influenza, and pneumonia), total cancers, and a
Banning Genetic Discrimination
Authors: Henry T. Greely
Journal: New England Journal of Medicine (2005)

Interview with Professor Henry Greely on genetic discrimination and the Genetic Information Nondiscrimination Act of 2005. (07:09)Download On February 17, 2005, the U.S. Senate passed bill S. 306, the Genetic Information Nondiscrimination Act of 2005, by a vote of 98 to 0. The previous day, the White House had announced that "the Administration favors enactment of legislation to prohibit the improper use of genetic information in health insurance and employment [and] supports Senate passage of S. 306." But similar legislation has been introduced in every Congress since 1995, and President George W. Bush announced his backing for a law against genetic discrimination as early as June 2001. The House of Representatives is the sticking point: knowledgeable observers . . .
Gerster's Disapproval of the Haslam Traction Bar-Reply
Authors: John J. Douglass
Journal: JAMA (1913)

A copy of the letter given above was sent to the manufacturer referred to, who replies: We designed our instrument but one of our competitors copied it and called it Gerster's traction bar. We will continue to sell our traction bar, but we will not call it by any other name than Haslam's. We thought it a compliment to Dr. Gerster to call it Haslam's modification of Gerster's traction bar, but since he objects we will drop his name and take it all ourselves, being the rightful owners.
Arterial Calcification and Not Lumen Stenosis Is Highly Correlated With Atherosclerotic Plaque Burden in Humans: A Histologic Study of 723 Coronary Artery Segments Using Nondecalcifying Methodology
Authors: Giuseppe Sangiorgi, John A Rumberger, Arlen Severson, William D Edwards, Jean Gregoire, Lorraine A Fitzpatrick, Robert S Schwartz
Journal: Journal of the American College of Cardiology (1998)
Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in the human endometrium.
Authors: M L Iruela-Arispe, P Porter, P Bornstein, E H Sage
Journal: Journal of Clinical Investigation (1996)

Thrombospondin-1 (TSP1), a multifunctional extracellular matrix glycoprotein, has been shown to suppress the angiogenic response in vivo and in vitro. We hypothesized that TSP1 might play a role in the inhibition of capillary morphogenesis during the endometrial cycle and examined its expression in 46 human endometrial specimens. Our results show that the expression of TSP1 in the endometrium is (a) cycle-dependent, (b) associated with periods of low capillary growth, and (c) regulated by progesterone. TSP1 protein was identified in the basement membrane of capillaries of the functional endometrium during the secretory phase. Abundant expression of TSP1 mRNA in the secretory phase was also detected by in situ hybridization, in contrast to the low levels seen in the proliferative phase. These findings were confirmed by Northern analysis of proliferative and secretory endometrium. Transcripts for TSP1 were observed predominantly in stromal cells, but signal was also detected in some endothelial and smooth muscle cells. Since the proliferation of endometrial tissue is regulated by steroid hormones, we tested the effects of estrogen and progesterone on TSP1 expression by stromal cells isolated from human endometrium. We found that levels of TSP1 mRNA and protein were increased after incubation with progesterone. Maximal stimulation of mRNA was observed after 8 h of treatment with 10-50 microM progesterone, and the effect was suppressed by the progesterone antagonist RU-486. Induction by progesterone was cell-specific and equivalent to the stimulation mediated by PDGF. Finally, the levels of TSP1 present in progesterone-stimulated cultures were sufficient to inhibit the migration of endothelial cells in vitro; this effect was nullified by anti-TSP antibodies. We therefore propose that the production of TSP1 at later stages of the endometrial cycle is linked to the inhibition of vessel formation and that TSP1 expression is progesterone-dependent in this tissue.
LACTIC ACID IN METABOLISM.WITH A NOTE ON THE CAUSE OF FATTY CHANGES IN THE ORGANISM.
Authors: ARTHUR R. MANDEL
Journal: JAMA (1906)

The first researches on the subject of metabolism sought to determine the quantity of proteid, fat and carbohydrate destroyed by an organism in a given time and under definite conditions. Much has recently been accomplished toward an explanation of the intermediary steps involved in the destruction of the foodstuffs by the organism. Thus glycocoll, a product of proteid metabolism, may be united with benzoic acid in the organism and be eliminated in large quantity in the urine, but no similar method will cause the elimination of leucin, or of alanin, products of proteid destruction. The present research concerns the subject of the position of lactic acid in general metabolism, and represents work accomplished at various times during two and a half years, involving feeding experiments on 24 dogs. Hoppe-Seyler believed that when dextrose was destroyed in the body it first broke up into two molecules of lactic acid. Neucki and
Myofibrillar ATPase activity in the transplanted canine heart
Authors: D. A. BARNHORST, J. R. MUIR, V. L. WILLMAN, R. E. OLSON
Journal: Cardiovascular Research (1973)

Journal Article Myofibrillar ATPase activity in the transplanted canine heart Get access DONALD A. BARNHORST, DONALD A. BARNHORST 2 From the Departments of Biochemistry and Surgery, St. Louis University School of Medicine, St. Louis, Missouri 63104, U.S.A. 2Dr. Barnhorst was a trainee of the National Heart Institute. Part of this investigation was taken from a thesis submitted by Dr. Barnhorst to the Graduate School of St. Louis University in partial fulfilment of the requirements for the Ph.D. examination. Search for other works by this author on: Oxford Academic PubMed Google Scholar JOHN R. MUIR, JOHN R. MUIR From the Departments of Biochemistry and Surgery, St. Louis University School of Medicine, St. Louis, Missouri 63104, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar VALLEE L. WILLMAN, VALLEE L. WILLMAN From the Departments of Biochemistry and Surgery, St. Louis University School of Medicine, St. Louis, Missouri 63104, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT E. OLSON ROBERT E. OLSON From the Departments of Biochemistry and Surgery, St. Louis University School of Medicine, St. Louis, Missouri 63104, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 7, Issue 3, May 1973, Pages 370–374, https://doi.org/10.1093/cvr/7.3.370 Published: 01 May 1973
Inhibition of the Raf–MEK1/2–ERK1/2 Signaling Pathway, Bcl-xL Down-Regulation, and Chemosensitization of Non-Hodgkin’s Lymphoma B Cells by Rituximab
Authors: Ali R. Jazirehi, Mario I. Vega, Devasis Chatterjee, Lee Goodglick, Benjamin Bonavida
Journal: Cancer Research (2004)

Abstract Rituximab (Rituxan, IDEC-C2B8) has been shown to sensitize non-Hodgkin’s lymphoma (NHL) cell lines to chemotherapeutic drug-induced apoptosis. Rituximab treatment of Bcl-2–deficient Ramos cells and Bcl-2–expressing Daudi cells selectively decreases Bcl-xL expression and sensitizes the cells to paclitaxel-induced apoptosis. This study delineates the signaling pathway involved in rituximab-mediated Bcl-xL down-regulation in Ramos and Daudi NHL B cells. We hypothesized that rituximab may interfere with the extracellular signal-regulated kinase (ERK) 1/2 pathway, leading to decreased Bcl-xL expression. Rituximab (20 μg/mL) inhibited the kinase activity of mitogen-activated protein kinase kinase (MEK) 1/2 and reduced the phosphorylation of the components of the ERK1/2 pathway (Raf-1, MEK1/2, and ERK1/2) and decreased activator protein-1 DNA binding activity and Bcl-xL gene expression. These events occurred with similar kinetics and were observed 3 to 6 hours after rituximab treatment. Rituximab-mediated effects were corroborated by using specific inhibitors of the ERK1/2 pathway, which also reduced Bcl-xL levels and sensitized the NHL B cells to paclitaxel-induced apoptosis. Previous findings implicated a negative regulatory role of the Raf-1 kinase inhibitor protein (RKIP) on the ERK1/2 pathway. Rituximab treatment of NHL B cells significantly up-regulated RKIP expression, thus interrupting the ERK1/2 signaling pathway through the physical association between Raf-1 and RKIP, which was concomitant with Bcl-xL down-regulation. These novel findings reveal a signaling pathway triggered by rituximab, whereby rituximab-mediated up-regulation of RKIP adversely regulates the activity of the ERK1/2 pathway, Bcl-xL expression, and subsequent chemosensitization of drug-refractory NHL B cells. The significance of these findings is discussed.
Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation
Authors: Régis Peffault de Latour, Rodrigo T. Calado, Marc Busson, Jeffrey Abrams, Nadir Adoui, Marie Robin, Jérôme Larghero, Nathalie Dhedin, Alienor Xhaard, Emmanuel Clave, Dominique Charron, Antoine Toubert, Pascale Loiseau, Gérard Socié, Neal S. Young
Journal: Blood (2012)
Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions
Authors: J Yu
Journal: Gut (2002)

Helicobacter pylori blood group antigen binding adhesin (BabA) mediates bacterial adherence to human blood group antigens on gastric epithelium. Although strains harbouring babA2 were recently found to be associated with peptic ulcer and gastric cancer, the role of babA2 in cellular turnover, severity of gastritis, and premalignant changes is poorly understood.We correlated H pylori babA2, vacuolating toxin (vacA), and cytotoxin associated gene A (cagA) genotypes with the severity of gastric inflammation and epithelial cell turnover in a group of Chinese patients from an area with a high incidence of gastric cancer.H pylori isolates were obtained from 104 Chinese patients who participated in a gastric cancer prevention programme. Genotype variants of babA2, vacA, and cagA were determined by polymerase chain reaction. Antrum and corpus histopathology was examined according to the updated Sydney classification. Apoptosis was scored by terminal uridine deoxynucleotidyl nick end labeling (TUNEL) and proliferation by Ki-67 immunostaining.Of the 104 patients, 102 (98.1%) harboured cagA(+) strains and all had vacA s1 genotype. The babA2(+) strains were found in 83 (79.8%) patients and were associated with higher lymphocytic infiltration (p=0.028), presence of glandular atrophy (odds ratio (OR) 7.5, 95% confidence interval (CI) 2.3-24.3), and intestinal metaplasia (OR 7.4, 95% CI 2.2-25.3) in the antrum. Increased epithelial proliferation was also noted in individuals infected with babA2(+) strains (p=0.025). Strains harbouring cagA(+)/vacA s1 genotypes lacked this association in the absence of babA2.The presence of babA2(+) H pylori strains alone or in combination with cagA(+) and vacA s1 was associated with the presence of preneoplastic gastric lesions.
Capacity building in collaborative research is essential
Authors: Prem K Mony, Anura Kurpad, Mario Vaz
Journal: BMJ (2005)

EDITOR—Scientists from developing countries are seriously under-represented in various areas of health research.1 2 Capacity building in developing countries is essential to improve health research and reduce health inequity.3 4 We report a retrospective analysis of original articles that appeared in the BMJ , the New England Journal of Medicine , and the Journal of Epidemiology and Community Health …