tbuckley/cabot-search huggingface dataset:
An Experimental Investigation of the Action of Chloral, Opium, and Bromide of Potassium
Authors: S. Ringer, H. Sainsbury
Journal: BMJ (1883)

TER'I.MDI CdbOZ.01 Ilaullue is alw a nohw aiWlige colour, and may b used a above tA &fdark powdet, and gves asngreeabh ale bhili-jmu4le sitain.and,if used after carmine or piorocaine, the cell body and inter- cellular substance will be preerred by the induline, and the nuclei and connective fibres by the otlers.t disaolvea In' warm water or dilute alcohol.Maroon, phosphine, and cenrse are new to histology.lble8taiiing.--Methylanilin violet, andiodine,malachiteormethyl treen, combined, give beautiful results.I first worked with aqueous solutions, which yielded good preparations, but now use an alcoholic mixture in the following way.Make a saturated solution of violet In strong slcohol, and filter.Do the same .withthe green, leaving Bome granules in excess at the bottomn of tho vessel; this solution is a greenish-blue.Filter anid add the violet solution to it, drop by drop, till the mixture is the colour of Prusian blue, wbich soon oc- curs.If a large quantitv be made for futue use, add a little strong carbolic acid solution, about three drops per ounce of the solution, to prevent decomposition, and to retard the acetic change in the alcohol, which wouldl soon spoil the dye.k'ilter about twenty drops into a watch glass, an(d diluto with spirit, and immerse sections for five to ten minutes; waqh off excess in ordinary, water, or better, drain off on filter paper, and set in saturated solution of acetate of potash, and monnt in a mixtutire of equal parts of pure glycerine and acetate of potash.This gives good preparations for several weeks; batt the dyes nmayob fixzed by placing the sections, for three to five minutes, in a mixture of equal parts of a saturated aqueous solution of tannin, to wlich alittle carbolic acid has been added, and distilled water.Then wash in water, and transfer, for the same time, to a mixture of rather more than one part of tartar emetic,
PROTOPORPHYRIN, CIRRHOSIS AND HEPATOMATA IN THE LIVERS OF MICE GIVEN GRISEOFULVIN.
Authors: E. WESTON HURST, G. E. PAGET
Journal: British Journal of Dermatology (1963)

Journal Article PROTOPORPHYRIN, CIRRHOSIS AND HEPATOMATA IN THE LIVERS OF MICE GIVEN GRISEOFULVIN. Get access E. WESTON HURST, M.D., D.Sc., E. WESTON HURST, M.D., D.Sc. Research Department, Imperial Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire Search for other works by this author on: Oxford Academic Google Scholar G. E. PAGET, M.D. G. E. PAGET, M.D. Research Department, Imperial Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 3, 1 March 1963, Pages 105–112, https://doi.org/10.1111/j.1365-2133.1963.tb13946.x Published: 01 March 1963
Analysis of <i>Helicobacter pylori vacA </i>and<i>cagA</i> genotypes and serum antibody profile in benign and malignant gastroduodenal diseases
Authors: D Basso, F Navaglia, L Brigato, M G Piva, A Toma, E Greco, F Di Mario, F Galeotti, G Roveroni, A Corsini, M Plebani
Journal: Gut (1998)

Background — Helicobacter pylori species comprise different strains, cytotoxic and non-cytotoxic, which can be identified on the basis of their genomic pattern. Aims —(1) To evaluate the polymorphism of the vacA gene and to ascertain whether the cagA gene is present in patients with gastric adenocarcinoma. (2) To study the anti- H pylori antibody profile using western blotting. Patients —Twenty one patients with gastric adenocarcinoma and 71 with H pylori associated benign disease (nine gastric ulcer, 29 duodenal ulcer, 25 antral gastritis, and eight duodenitis). Methods —The polymerase chain reaction was used to verify the presence or absence of cagA and to study the polymorphism of vacA in gastric mucosal samples obtained during endoscopy for patients with benign diseases and at surgery for patients with gastric adenocarcinoma. Fasting sera were used to assess anti- H pylori antibodies against different H pylori antigens by western blotting. Results — cagA gene and the allele s1 of vacA were significantly less frequent in patients with antral gastritis (60% and 60%) compared with patients with gastric adenocarcinoma (94% and 100%) and with other non-malignant gastroduodenal diseases (93% and 87%) (χ 2 =16.01, p&lt;0.001; and χ 2 =13.97, p&lt;0.01). In patients with gastric adenocarcinoma, antibodies against a 74 kDa H pylori antigen were less frequently found than in patients with benign diseases. Conclusions — H pylori infection caused by cagA positive/ vacA s1 strains is a frequent finding in patients with gastric adenocarcinoma. Prospective studies are needed to confirm whether the low incidence of positive serological response to the 74 kDa H pylori antigen in patients with gastric adenocarcinoma is important.
Gallstones and the risk of cancer.
Authors: A B Lowenfels
Journal: Gut (1980)

For both males and females the age-standardised prevalence of asymptomatic gallstones found at necropsy in 15 countries correlated strongly with age-standardised mortality from cancers of the uterus, large bowel, and stomach. When deaths from cholecystitis were used as another measure of the frequency of gallstones similar positive correlations were observed across 28 countries. The results suggest that cholelithiasis and several common cancers share similar epidemiological and perhaps metabolic factors.
TCT-193 Use Of Drug-Eluting Balloon For The Treatment Of In-stent Restenosis After Carotid Artery Stenting
Authors: Piero Montorsi, Antonio Bartorelli, Franco Fabbiocchi, Stefano Galli, Alessandro Lualdi, Paolo Ravagnani, Giovanni Teruzzi, Daniela Trabattoni, Sarah Troiano
Journal: Journal of the American College of Cardiology (2012)
What Is the Relationship Between the Response of Angina to Coronary Surgery and Anatomical Success?
Authors: HARVEY J. MATLOF, EDWIN L. ALDERMAN, LEWIS WEXLER, NORMAN E. SHUMWAY, DONALD C. HARRISON
Journal: Circulation (1973)

Analysis of clinical response, graft patency, and treadmill performance was carried out in 72 patients one year after aortocoronary saphenous vein bypass surgery. Thirty-four of 46 patients with complete relief of angina had all grafts patent at one year, as opposed to 4 of 14 unimproved patients ( P &lt; 0.01); 84.4% of 77 grafts in the former group were patent, as compared with 48% of 25 grafts in the latter group ( P &lt; 0.01). Similarly, treadmill tolerance and end-exercise heart rate were significantly increased in patients experiencing significant or complete clinical relief. Unimproved patients showed no improvement in these parameters. Individual observations indicated that graft patency did not always ensure clinical relief or abolition of ischemic treadmill responses.
Picasso's Roots
Authors: William Faucon
Journal: JAMA (1987)

To the Editor.—  Andalusia is in the southern part of Spain; Malaga is the capital of an Andalusian province. It was in Malaga that Pablo Picasso was born and where he spent his early years before moving with his family to Galicia and then later to Barcelona.  Although he lived in Catalonia for several years, I doubt that Picasso ever mastered the Catalan language. He certainly never considered himself a Catalan national, as was stated inTHE JOURNAL. 1   Joan Mirḿ and Salvador Dalḿ bring honor to the Catalan people. Allow Picasso to do the same for the Andalusian.
Influence of Epicardial Patches on Defibrillation Threshold With Nonthoracotomy Lead Configurations
Authors: Parwis C. Fotuhi, Raymond E. Ideker, Salim F. Idriss, Richard L. Callihan, Robert G. Walker, Eckhard U. Alt
Journal: Circulation (1995)

Background In previous studies, epicardial patch electrodes decreased transthoracic defibrillation efficacy. We studied the effects of two inactive epicardial 14-cm 2 titanium mesh patches on defibrillation energy requirements with nonthoracotomy internal lead configurations. Methods and Results A 6/6-millisecond biphasic shock waveform was delivered via several electrode configurations 10 seconds after ventricular fibrillation was initiated with a 60-Hz generator. In two series, a total of 16 dogs (weight, 23.3±2.4 kg) underwent an up-down defibrillation protocol. In the first series, the defibrillation threshold (DFT) was determined for each electrode configuration in the presence of two inactive epicardial patches. In the second series, DFTs were determined in the presence of an inactive right ventricular (RV) or left ventricular (LV) patch alone. For several nonthoracotomy lead configurations tested in the first 8 dogs, the mean±SD DFT energy increased 49% to 97% with two inactive patches on the heart compared with no patches on the heart as follows: RV to superior vena caval (SVC) electrode, from 8.9±2.6 to 18.0±14.3 J; RV to SVC plus subcutaneous array electrode, from 7.0±2.4 to 10.7±5.3 J; RV to subcutaneous pectoral plate electrode, from 6.2±1.3 to 11.4±4.0 J ( P ≤.05). The lowest DFT was achieved by defibrillating between the epicardial patches (3.8±3.3 J). The second series showed that DFT voltage requirements increased significantly for all three nonthoracotomy lead configurations with the inactive LV patch alone ( P ≤.05) but not with the inactive RV patch alone. Conclusions Inactive epicardial patches can significantly increase the defibrillation energy requirements for nonthoracotomy lead configurations. This negative impact may be due to an insulating effect of the patches and to a disturbance of the potential gradient field under the patches. If the same holds true in patients, these results have clinical implications. Functioning epicardial patch leads should be incorporated in the defibrillation lead system if already present. If the LV patch is nonfunctioning, such as because of a lead fracture, the marked increase in DFT due to an inactive LV patch calls for thorough DFT testing during surgery and, in selected patients, may necessitate patch removal to produce an effective transvenous-based system.
1177 RAPID AND SUSTAINED ACHIEVEMENT OF UNDETECTABLE HCV RNA DURING TREATMENT WITH RITONAVIR-BOOSTED DANOPREVIR/PEG-IFNa-2A/RBV IN HCV GENOTYPE 1 OR 4 PATIENTS: DAUPHINE WEEK 12 INTERIM ANALYSIS
Authors: G. Everson, C. Cooper, C. Hezode, M.L. Shiffman, E. Yoshida, T. Beltran-Jaramillo, P. Ferenci, S. Zeuzem, M. Brunda, N. Shulman, M. Navarro, A. Voulgari, I. Najera, S. Le Pogam, E.S. Yetzer
Journal: Journal of Hepatology (2012)
Successful Repair of a Damaged Duodenal Stent by Cutting Stent Wires and Placement of a Second Stent
Authors: I. Maetani, J. Shimura, T. Ukita, H. Inoue, Y. Igarashi, Y. Sakai
Journal: Endoscopy (2002)

Duodenal stenting has been gradually established in recent years because it is less invasive than standard surgical procedures and produces a rapid therapeutic response. For palliation of both duodenal and biliary stenoses, double stenting may be performed. Duodenal stents offer a great advantage in allowing endoscopic retrograde cholangiopancreatography (ERCP) without the need for balloon dilation. When biliary stent dysfunction occurs, the patient undergoes diagnostic and/or therapeutic ERCP across the duodenal stent. We encountered a duodenal stent fracture in a patient who required repeated ERCPs for stent dysfunction. Duodenal stent fractures have not previously been reported. The damaged stent was successfully repaired by using a cutting wire filament and placing another duodenal stent coaxially with the first. Clinicians should be aware of the possibility of stent fracture following endoscopic procedures, such as an ERCP, that require passage through the stent. The procedure described in this report would be of significant benefit if a gastrointestinal stent is fractured and occluded by a broken part.
Short-term control of brittle diabetes using a Biostator.
Authors: H Connor, G Atkin, E Attwood
Journal: BMJ (1982)

doses intradermally and then 2 mg antigen-binding fragments in saline intravenously an infusion of 200 mg in 5% dextrose was set up and given over one hour with close monitoring of vital signs.The infusion started 24 hours after ingestion.The free serum digoxin concentration fell dramatically to undetectable concentrations (< 1 ngfml) while the total blood concen- tration, comprised almost solely of digoxin bound inactively to antigenbinding fragments, correspondingly rose (figure).The reduction in free Antigen-binding digoxin 100 01 C -*20 - 20 V ~~~~~~~~~~~~~~~c 4, ~~~~~~~~~~~~~~~3 10 10 V~~~~~~~~~~~~~~~c Cps 5 - tb,v ---_ Pasim -5 3 o %Ob ' c-o.. btQSSium 5 Free 0 8 16 24 32 40 48 56 64 Time (hours)Time course of total serum digoxin concentration, free serum digoxin concentration, and serum potassium concentration immediately before and after injection of antigen-binding fragments of digoxin.Values are expressed as units on a logarithmic scale.Arrows indicate timing of infused potassium supplements.digoxin was accompanied by a fall in serum potassium, which was corrected by infused supplements, using a total of 120 mmol.The electrocardiogram showed resolution of ectopic activity and sinus bradycardia.The coagulation disturbance was corrected using fresh frozen plasma and vitamin K.
'Do Not Resuscitate' Orders-Reply
Authors: Stuart J. Youngner
Journal: JAMA (1985)

<h3>In Reply.—</h3> We could not agree more with Dr Raskin's concern that DNR decisions are too often made by those with the "least experience and training in such matters." We would encourage more formal education about nontreatment decisions in residensy programs. Furthermore, senior faculty and attending physicians should not leave these critical and delicate matters to the youngest and most inexperienced physicians. To do so is not only a disservice to patients and families but may be quite harmful to the professional and personal development of young physicians.
SOME PHASES OF DENTAL EDUCATION.
Authors: A E Baldwin
Journal: JAMA (1904)

In order to realize that we are living at a A'ery rapid rate, we have but to look backward to see the progress that has been made in almost all lines within the memory of even the younger men of the profession. By observation we are shown that the education required to enable one to call oneself an educated artisan, scientist or professional person was very meager as compared with the demands and the requirements of to-day. The question often arises in my mind whether or not stomatology, as a specialty, has kept pace with the march of progress in other lines, and especially in coincident professional lines. Much has been written, much is being written, and much more is being thought, as to the proper lines of progressional development in education in our specialty. Within the past few years we have seen that the National Association of Dental Faculties
Wnt/Snail Signaling Regulates Cytochrome<i>c</i>Oxidase and Glucose Metabolism
Authors: Su Yeon Lee, Hyun Min Jeon, Min Kyung Ju, Cho Hee Kim, Gyesoon Yoon, Song Iy Han, Hye Gyeong Park, Ho Sung Kang
Journal: Cancer Research (2012)

Wnt signaling plays a critical role in embryonic development, and its deregulation is closely linked to the occurrence of a number of malignant tumors, including breast and colon cancer. The pathway also induces Snail-dependent epithelial-to-mesenchymal transition (EMT), which is responsible for tumor invasion and metastasis. In this study, we show that Wnt suppresses mitochondrial respiration and cytochrome C oxidase (COX) activity by inhibiting the expression of 3 COX subunits, namely, COXVIc, COXVIIa, and COXVIIc. We found that Wnt induced a glycolytic switch via increased glucose consumption and lactate production, with induction of pyruvate carboxylase (PC), a key enzyme of anaplerosis. In addition, Wnt-induced mitochondrial repression and glycolytic switching occurred through the canonical β-catenin/T-cell factor 4/Snail pathway. Short hairpin RNA-mediated knockdown of E-cadherin, a regulator of EMT, repressed mitochondrial respiration and induced a glycolytic switch via Snail activation, indicating that EMT may contribute to Wnt/Snail regulation of mitochondrial respiration and glucose metabolism. Together, our findings provide a new function for Wnt/Snail signaling in the regulation of mitochondrial respiration (via COX gene expression) and glucose metabolism (via PC gene expression) in tumor growth and progression.
Metabolic-Morphologic Discordant Solitary Skeletal Muscle Metastasis on [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Scan in Synchronous Lung and Esophageal Cancer: A Lesson
Authors: Suat-Jin Lu, Manuel Rodriguez-Justo, Samantha Read, Jamshed B. Bomanji
Journal: Journal of Clinical Oncology (2012)
Formation of UV-induced apoptosis relates to the cell cycle
Authors: K. DANNO, T. HORIO
Journal: British Journal of Dermatology (1982)

The relationship of the rate of epidermal proliferation to ultraviolet (UV)-induced cell death, namely sunburn cell (SC) formation, was investigated in vivo using the guinea-pig model. The number of SCs was correlated with (1) cellophane tape stripping which stimulates the proliferation rate and (2) treatment with antimitotic and antimetabolic agents which suppress the proliferation rate. The tape stripping performed 14 h before UV irradiation significantly increased the number of SCs counted 24 h after UV irradiation from a mean of 17.4 to 62.6 per section, and the tritiated thymidine (TdR-3H)-labelling index (LI) increased from a mean of 8.1 to 27.4%. SC counts and LI were markedly decreased by the intradermal injection of colchicine, methotrexate, hydroxyurea or 5-fluorouracil given once immediately after the tape stripping. The autoradiographic study showed that 23.2% of SCs were labelled when TdR-3H was given intradermally 1 h before UV exposure, while no SCs were labelled when TdR-3H was given immediately after UV exposure. The labelled SC count (23.2%) which presumably represents S phase cells at the time of UV exposure, was higher than the LI (mean 8.1%). These results suggest that proliferating cells, possibly S phase cells, may be responsible for SC formation.
Postgraduate Year One: Lessons in Caring
Authors: Dale Yoo
Journal: Annals of Internal Medicine (2009)

Medical Writings: Book Notes4 August 2009Postgraduate Year One: Lessons in CaringDale Yoo, MDDale Yoo, MDFrom Emory University School of Medicine, Atlanta, Georgia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-3-200907070-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Heilman KM. 192 pages. New York: Oxford Univ Pr; 2008. $24.95. ISBN 9780195321265. Order at www.oup.com/us/.Format: Softcover book.Field of medicine: Medical education.Audience: All those in the medical field will enjoy this recount of anecdotes from Dr. Heilman's internship at Bellevue Hospital in New York.Purpose: To share the lessons learned during internship, which Heilman states “have had the greatest influence on [him] and helped guide [his] career.”Content: This book is an anthology of 24 anecdotes from Heilman's internship at Bellevue Hospital. With each brief vignette, he highlights an important lesson that he and others learned from ... Author, Article, and Disclosure InformationAffiliations: From Emory University School of Medicine, Atlanta, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 August 2009Volume 151, Issue 3Page: 220KeywordsForecastingMedical education ePublished: 4 August 2009 Issue Published: 4 August 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Low dose of propranolol prevents the development of heart failure by restoring the defective interaction of FKBP12.6 with cardiac ryanodine receptor
Authors: Masahiro Doi, Masafumi Yano, Shigeki Kobayashi, Masateru Kohno, Masae Suetsugu, Takahiro Tokuhisa, Shin-ichi Okuda, Tomoko Ohkusa, Michihiro Kohno, Masunori Matsuzaki
Journal: Journal of the American College of Cardiology (2002)
499 GENOTYPE 2 AND 3 RECCURENT HEPATITIS C AFTER LIVER TRANSPLANTATION: EXCELLENT RESULTS WITH SUBOPTIMAL DOSES OF ANTIVIRAL THERAPY
Authors: R. Vigano, F.R. Ponziani, L.S. Belli, M. Vangeli, G. Pinzello, A. Gasbarrini, L. Pasulo, E. De Martin, P. Burra, M. Pompili, M. Colledan, U. Cillo, S. Fagiuoli
Journal: Journal of Hepatology (2009)
Off-label abuse of antibiotics by bacteria
Authors: VK Viswanathan
Journal: Gut Microbes (2014)

Antibiotics and antibiotic resistance made news on several fronts in the past year. Many public health organizations, including the CDC, used terms such as "crisis", "catastrophic consequences", and "nightmare scenario" to highlight the rapid emergence and spread of antibiotic resistance. A report from the Pew Commission on Industrial Farm Animal Production, on the fifth anniversary of the publication of its landmark 2008 report, noted that state and federal legislative efforts to limit non-therapeutic use of antibiotics in animal production were thwarted by drug and food animal industries. In its lobbying disclosures, the Farm Bureau stated that such efforts to limit use of animal antibiotics were "based on emotion and no credible peer reviewed science." Meanwhile, there have been inexorable advances in our understanding of the molecular mechanisms by which antibiotics induce diversity and resistance in bacteria. This article reviews one study that probed the role of the bacterial general stress response in sub-inhibitory antibiotic-induced mutagenesis and antibiotic resistance.
Endoscopic radiofrequency ablation for early esophageal squamous cell neoplasia: report of safety and effectiveness from a large prospective trial
Authors: Shun He, Jacques Bergman, Yueming Zhang, Bas Weusten, Liyan Xue, Xiumin Qin, Lizhou Dou, Yong Liu, David Fleischer, Ning Lu, Sanford Dawsey, Gui-Qi Wang
Journal: Endoscopy (2015)

<b>Background and study aims: </b>Endoscopic radiofrequency ablation (RFA) is an established therapy for Barrett's esophagus. Preliminary reports, limited by low patient numbers, also suggest a possible role for RFA in early esophageal squamous cell neoplasia (ESCN). The aim of this study was to evaluate the safety and effectiveness of RFA for early ESCN (moderate/high grade intraepithelial neoplasia [MGIN/HGIN] and early flat-type esophageal squamous cell carcinoma [ESCC]). <b>Patients and methods:</b> This prospective cohort study included patients with at least one flat (type 0-IIb) unstained lesion (USL) on Lugol's chromoendoscopy and a consensus diagnosis of MGIN, HGIN, or early ESCC. RFA was used at baseline to treat all USLs, and then biopsy (and focal RFA if USL persisted) was performed every 3 months until all biopsies were negative for MGIN, HGIN, and ESCC. The main outcome measurements were complete response at 3 and 12 months (absence of MGIN, HGIN, and ESCC), neoplastic progression, and adverse events. <b>Results:</b> A total of 96 patients participated (MGIN 45, HGIN 42, early ESCC 9). At 3 and 12 months, 73 % (70/96) and 84 % (81/96), respectively, showed a complete response. Two patients (2 %) progressed (MGIN to HGIN; HGIN to T1m2 ESCC); both were treated endoscopically and achieved complete response. Stricture occurred in 20 patients (21 %), all after circumferential RFA. Lugol's + RFA 12 J/cm<sup>2</sup> (single application, no cleaning) was the favored baseline circumferential RFA technique (82 % 12-month complete response [14/17], 6 % stricture [6/17]). <b>Conclusion:</b> In patients with early ESCN, RFA was associated with a high complete response rate and an acceptable safety profile.