tbuckley/cabot-search huggingface dataset:
Cutaneous mucinosis and polymyositis as a presenting feature of hypothyroidism
Authors: M.R. Griffiths, R.A. Carr, F. Humphreys
Journal: British Journal of Dermatology (2007)

Journal Article Cutaneous mucinosis and polymyositis as a presenting feature of hypothyroidism Get access M.R. Griffiths, M.R. Griffiths Departments of Dermatology and Histopathology, Warwick Hospital, Lakin Road, Warwick CV34 5BW, U.K. E‐mail: mrgriffiths@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar R.A. Carr, R.A. Carr Departments of Dermatology and Histopathology, Warwick Hospital, Lakin Road, Warwick CV34 5BW, U.K. Search for other works by this author on: Oxford Academic Google Scholar F. Humphreys F. Humphreys Departments of Dermatology and Histopathology, Warwick Hospital, Lakin Road, Warwick CV34 5BW, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 1, 1 January 2008, Pages 186–187, https://doi.org/10.1111/j.1365-2133.2007.08257.x Published: 01 January 2008
I branching formation in erythroid differentiation is regulated by transcription factor C/EBPα
Authors: Yuh-Ching Twu, Chie-Pein Chen, Chuang-Yi Hsieh, Cheng-Hwai Tzeng, Chien-Feng Sun, Shih-Hsin Wang, Mau-Sun Chang, Lung-Chih Yu
Journal: Blood (2007)
Treatment of Barrett's Esophagus by Endoscopic Argon Plasma Coagulation
Authors: F. L. Dumoulin, B. Terjung, M. Neubrand, C. Scheurlen, H. P. Fischer, T. Sauerbruch
Journal: Endoscopy (1997)

Barrett's esophagus is a premalignant condition characterized by the presence of specialized columnar epithelium in the distal esophagus. Conventional medical or surgical treatments do not consistently lead to a regression of Barrett's epithelium. However, restoration of squamous mucosa can occur in an anacid environment after endoscopic ablation of metaplastic epithelium. We report here on two patients with long-standing history of Barrett's esophagus who were treated with endoscopic argon plasma coagulation. By six months of endoscopic treatment, Barrett's epithelium had regressed by more than 50 %, being replaced by apparently normal squamous epithelium in both patients. Extensive histological sampling confirmed the presence of squamous epithelium indistinguishable from normal esophageal mucosa. Both patients were asymptomatic under concomitant therapy with proton pump inhibitors with the exception of slight retrosternal discomfort the day after treatment. This demonstrates that endoscopic argon plasma coagulation may be considered for the treatment of Barrett's esophagus.
RPS Delegate Report, Part 1
Authors: Scott Reid
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A New Form of Splint for the Treatment of Fractures into and in the Vicinity of the Elbow-Joint
Authors: C. R. Illingworth
Journal: BMJ (1889)

ttrve regions marked.There are some convenient outlines for recording diseased conditions of the larynx, nose, ear, eye, and fundus oculi; thirty-three sketches of bones and joints are also to be obtained.Some " case sheets " suggested by Dr. Cosgrave are drawn up on the plan of a hospital bed card, and will Be found convenient; another sheet of "instructions to patient or nurse" resembles a hospital diet card.The temperature charts are rather too small, but have the recommendation of cheapness.The " per- fect " clinical chart is larger and is neatly printed, but hardly deserves the extravagant praise claimed for it by the title "perfect."Physicians who consider it desirable to have the temperature taken oftener than twice in the twenty-four hours in serious fever cases-and this is now probably a very general custom-will perhaps consider the chart somewhat imper- fect.The clinical figures are most excellently done and very useful, but there is little either of a novel or specially commend- able character in the charts.
Postoperative Streptococcal Wound Infection
Authors: Paul F. Gryska
Journal: JAMA (1970)

In a one-month period in 1969,13 postoperative wound infections due to group A β-hemolytic streptococci were discovered. The epidemic was controlled after discovery and treatment of the proven carrier, an anesthesiologist. The source of the carrier organism was the anal verge. His organism, that of eight of the patients, and a group A β-hemolytic streptococcus recovered on a fallout plate in an operating room (with the carrier in attendance) were identical as to bacteriogenic agglutination type.
Ozone, NO, and NO2: oxidant air pollutants and more.
Authors: J A Last, W M Sun, H Witschi
Journal: Environmental Health Perspectives (1994)

This article reviews the acute and chronic toxicity of the three oxidant air pollutants ozone, nitric oxide (NO), and nitrogen dioxide (NO2). The toxicity of binary mixtures of NO2 with other inhaled agents is also discussed. Newer studies are emphasized, especially those published in the last 5 years or still in press. Very recent data from our laboratory that suggest a new cellular mechanism of importance in lung injury in animals exposed to mixtures of ozone and NO2 that may have general relevance with regard to the effects of oxidant air pollutants on the lung are also presented.
Abstract 945: Metabolic syndrome increases the risk of primary liver cancer in the United States
Authors: Tania M. Welzel, Barry I. Graubard, Jessica A. Davila, Hashem B. El-Serag, Katherine A. McGlynn
Journal: Cancer Research (2011)

Abstract Background: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the two most common histologic types of primary liver cancer. Incidence rates of both HCC and ICC are increasing in the United States. Metabolic syndrome, characterized by increased fasting glucose level, central adiposity, dyslipoproteinemia and hypertension, has been linked with HCC and may also modify the risk of ICC. The magnitude of the association, however, has not been investigated at the population level in the US. We therefore examined the association between metabolic syndrome and the development of both primary liver cancers in the general U.S. population. Methods: All persons aged 65 years and older diagnosed with histologically confirmed HCC and ICC between 1993 and 2005 were identified in the SEER-Medicare linked database. The cases were compared to a 5% sample of individuals residing in the same geographic regions of the SEER registries as the cases. The prevalences of metabolic syndrome and other risk factors for HCC (HBV, HCV, unspecified viral hepatitis, alcoholic liver disease, unspecified cirrhosis, biliary cirrhosis, hemochromatosis, Wilson's disease, smoking) and ICC (biliary cirrhosis, cholangitis, cholelithiasis, choledochal cysts, HBV, HCV, unspecified viral hepatitis, alcoholic liver disease, non-specified cirrhosis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, smoking) were compared among the persons who developed cancer and the persons who did not. Adjusted odds ratios and 95% confidence intervals were calculated using logistic regression. Results: A total of 3,649 HCC cases, 743 ICC cases and 195,953 persons without cancer met the study inclusion criteria. Metabolic syndrome was significantly more common among persons who developed HCC (37.1%) and ICC (29.7%) than among persons who did not (17.1%, p&amp;lt;0.0001). In multiple logistic regression analyses that adjusted for demographics features and the other risk factors, metabolic syndrome remained significantly associated with an increased risk for HCC (OR=2.13; 95%CI=1.96-2.31, p&amp;lt;0.0001) and ICC (OR=1.56; 95% CI = 1.32-1.83, p&amp;lt;0.0001). Conclusions: Metabolic syndrome is a risk factor for development of both HCC and ICC in the general U.S. population. Given that approximately one-third of U.S. adults have metabolic syndrome, these findings have implications for the future incidence of both HCC and ICC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 945. doi:10.1158/1538-7445.AM2011-945
A New Picture Process.
Authors: A. G. Field
Journal: JAMA (1896)

Des Moines, Iowa, March 9, 1896.  To the Editor:  —I have taken considerable interest in the published reports of the penetration of Roentgen's X rays and the application of the discovery to surgery; as well as to reports of similar results without the use of Crookes tubes. By virtue of accident I can report similar result independent of Crookes tube, dynamo, or any other agent of electrical light or force, so far as I know. Some months ago I placed a piece of sensitized paper in a book and it was forgotten. When discovered a few days ago, the page of the book was clearly and legibly printed upon the sensitized paper, as a positive. The discovery was so bewildering that I did not think of fixing it at the time, but next morning, when I went to do so, the image had vanished, and I lost the evidence of
Donors agree financial arrangement to stimulate vaccine development
Authors: Andrew Jack
Journal: BMJ (2008)

UK paediatricians will debate a motion of no confidence in the General Medical Council's handling of disciplinary cases involving child protection work, at their professional association's forthcoming meeting.The motion has been put forward by 32 members of the Royal College of Paediatrics and Child Health and will be tabled at the college's annual spring meeting, to be held at York University from 14 April.Many but not all of the motion's signatories are members of Professionals Against Child Abuse, a group formed last year in response to high profile GMC cases against paediatricians.The motion argues that paediatricians are more harshly treated than other specialties, citing cases in which other doctors escaped removal from the register after convictions for assaulting children and viewing child pornography.The motion also accuses the GMC of giving too much weight to serial and vexatious complaints by campaigners and of failing to consider previous investigations that have exonerated paediatricians when starting proceedings against them.This constitutes double jeopardy, the paediatricians argue.Paul Davis, a consultant paediatrician in Cardiff and one of the signatories, said the fear of being struck off was a "powerful deterrent" in discouraging professionals from giving expert testimony and from making child protection referrals."The numbers on the child protection register have declined sharply," he said.A spokesperson for the GMC said, "It is extremely rare for a paediatrician to appear before a panel in connection with child protection work.Since 2004 panels have considered more than 600 cases.Only two could reasonably be said to have been about paediatricians involved in child protection work.Our critics are trying to create the impression that the GMC is intent on unfairly persecuting paediatricians involved in child protection work.Nothing could be further from the truth." Paediatricians debate a motion of no confidence in GMCUK NEWS Review shows growing trend for trials of new cancer drugs to stop early, p 793 WoRld NEWS Germany "has two tier health service" p 796 bmj.comCompany's decision to lengthen lipid lowering trial causes controversy
Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia☆
Authors: C MARTIN, R SCHULZ, H POST, K BOENGLER, M KELM, P KLEINBONGARD, P GRES, A SKYSCHALLY, I KONIETZKA, G HEUSCH
Journal: Cardiovascular Research (2007)

Objectives: Nitric oxide (NO) synthesis by NO synthases (NOS) requires oxygen. However, although counterintuitive, NO synthesis is increased in ischemic myocardium. Accordingly, mechanisms independent of the NOS pathway have been suggested to contribute to NO synthesis during ischemia. NO initiates detrimental as well as protective mechanisms in a concentration-dependent manner, thus aggravating or improving the outcome of ischemia. The aim of this study was to measure in situ interstitial NO concentrations in parallel to infarct size in anaesthetized pigs subjected to myocardial ischemia/reperfusion. The contribution of NOS-independent pathways to NO synthesis was studied using NOS blockade.
Multivariate prediction of in-hospital mortality after percutaneous coronary interventions in 1994–1996
Authors: Gerald T. O’Connor, David J. Malenka, Hebe Quinton, John F. Robb, Mirle A. Kellett, Samuel Shubrooks, William A. Bradley, Michael J. Hearne, Mathew W. Watkins, David E. Wennberg, Bruce Hettleman, Daniel J. O’Rourke, Paul D. McGrath, Thomas Ryan, Peter VerLee
Journal: Journal of the American College of Cardiology (1999)

OBJECTIVES Using recent data, we sought to identify risk factors associated with in-hospital mortality among patients undergoing percutaneous coronary interventions. BACKGROUND The ability to accurately predict the risk of an adverse outcome is important in clinical decision making and for risk adjustment when assessing quality of care. Most clinical prediction rules for percutaneous coronary intervention (PCI) were developed using data collected before the broader use of new interventional devices. METHODS Data were collected on 15,331 consecutive hospital admissions by six clinical centers. Logistic regression analysis was used to predict the risk of in-hospital mortality. RESULTS Variables associated with an increased risk of in-hospital mortality included older age, congestive heart failure, peripheral or cerebrovascular disease, increased creatinine levels, lowered ejection fraction, treatment of cardiogenic shock, treatment of an acute myocardial infarction, urgent priority, emergent priority, preprocedure insertion of an intraaortic balloon pump and PCI of a type C lesion. The receiver operating characteristic area for the predicted probability of death was 0.88, indicating a good ability to discriminate. The rule was well calibrated, predicting accurately at all levels of risk. Bootstrapping demonstrated that the estimate was stable and performed well among different patient subsets. CONCLUSIONS In the current era of interventional cardiology, accurate calculation of the risk of in-hospital mortality after a percutaneous coronary intervention is feasible and may be useful for patient counseling and for quality improvement purposes.
THE MOSQUITO AS A CARRIER OF DISEASE.
Authors: J. STEBBINS KING
Journal: JAMA (1903)

While preparing a paper for the Decatur (III.) Medical Society on the "Mosquito as a Carrier of Disease," I was surprised to learn, through the numerous medical journals consulted, that so many of our profession had adopted the extreme, and to me the erroneous, view that the mosquito was the only intermediate host for the transmission of yellow and malarial fevers. While the various scientific experiments made during the past few years prove conclusively that the mosquito is one great factor in the transmission of these fevers; and that by the extermination of the mosquito, and the proper precautions against allowing this insect to bite those afflicted with these diseases, a great reduction of the number of patients can be made in any community; yet, in my estimation, the evidence does not establish the fact that the mosquito is the only medium through which these fevers can be propagated.
Activated endothelial cells elicit paracrine induction of epithelial chloride secretion. 6-Keto-PGF1alpha is an epithelial secretagogue.
Authors: E D Blume, C T Taylor, P F Lennon, G L Stahl, S P Colgan
Journal: Journal of Clinical Investigation (1998)

Endothelial cells play a central role in the coordination of the inflammatory response. In mucosal tissue, such as the lung and intestine, endothelia are anatomically positioned in close proximity to epithelia, providing the potential for cell-cell crosstalk. Thus, in this study endothelial-epithelial biochemical crosstalk pathways were studied using a human intestinal crypt cell line (T84) grown in noncontact coculture with human umbilical vein endothelia. Exposure of such cocultures to endothelial-specific agonists (LPS) resulted in activation of epithelial electrogenic Cl- secretion and vectorial fluid transport. Subsequent experiments revealed that in response to diverse stimuli (LPS, IL-1alpha, TNF-alpha, hypoxia), endothelia produce and secrete a small, stable epithelial secretagogue into conditioned media supernatants. Further experiments identified this secretagogue as 6-keto-PGF1alpha, a stable hydrolysis product of prostacyclin (PGI2). Results obtained with synthetic prostanoids indicated that 6-keto-PGF1alpha (EC50 = 80 nM) and PGI2 stable analogues (EC50 = 280 nM) activate the same basolaterally polarized, Ca2+-coupled epithelial receptor. In summary, these findings reveal a previously unappreciated 6-keto-PGF1alpha receptor on intestinal epithelia, the ligation of which results in activation of electrogenic Cl- secretion. In addition, these data reveal a novel action for the prostacyclin hydrolysis product 6-keto-PGF1alpha and provide a potential endothelial- epithelial crosstalk pathway in mucosal tissue.
Rational dosage of non-cumulative drugs.
Authors: D B James
Journal: BMJ (1976)

D-V Strip of nail removed (A) and flaps of nail wall (B) and nail fold (C) reflected to expose segment of germinal matrix (D) to be excised.A simple and logical operation for unilateral embedded toenail was described by Heifetz in 1945.8This consists of removal of a small segment of germinal matrix on the affected side of the nail.No sutures are required and healing occurs within a few days.Mr Palmer and Mr Stevenson imply that their operation can be performed in the presence of sepsis, cutting through inflamed nail wall.A deliberate operation through inflamed tissues is bad surgical practice and sooner or later this will lead to severe exacerbations of infection.In infected cases it is safer to excise a small strip of embedded nail under local anaesthesia four weeks before surgery.This will enable an exact dissection of the portion of germinal matrix to be performed under ideal conditions.
Antipodean Equivalents of the Annals of Internal Medicine
Authors: C. B. KERR
Journal: Annals of Internal Medicine (1972)

Abroad1 October 1972Antipodean Equivalents of the Annals of Internal MedicineC. B. KERRC. B. KERRAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-654 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAustralia's medical journals, like its cities, show much evidence of British and American influences. British tradition dominates the Australian medical system, especially in the organisation of health services, professional hierarchies, and medical education. On the other hand, the Australian Medical Association, champion of private medical practice, has become embattled with the federal government over remuneration of physicians—mirroring confrontations of recent memory in the United States.American influences are most prominent in large university hospitals. A high proportion of specialist services are run by Australians who received part of their career training in the United States. Although the distinction is far... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Preventive and Social Medicine University of Sydney Sydney N.S.W. Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1972Volume 77, Issue 4Page: 654-655KeywordsMedical educationMedical servicesMemory Issue Published: 1 October 1972 PDF downloadLoading ...
Lyme Disease in Unwary Physicians: A Curbside Cluster
Authors: Joel D. Klein
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Environmental exposure to<i>Ixodes</i>ticks and subsequent infection with<i>Borrelia burgdorferi</i>has been associated with certain outdoor occupations.<sup>1-3</sup>For physicians, infectious occupational hazards include human immunodeficiency virus and hepatitis B encountered in the clinical setting; certain arthropod-borne diseases (typhus, malaria, yellow fever) have been acquired by physicians in field hospitals. However, an increased risk of Lyme disease has not been previously described. Five cases of Lyme disease occurred over 1 year among physicians at a children's hospital in an endemic area. All had erythema migrans, two had neurologic involvement, and each presented to the infectious diseases service as "curbside" consultations (Table). This series stimulated us to consider the possibility that physicians might be uniquely vulnerable to Lyme disease. Whether five cases among 83 employed physicians and 55 pediatric residents represents a true clustering is unknown (there may also have been additional cases of which we are
Distribution of ATPase-positive Langerhans cells in normal adult human skin
Authors: H. CHEN, J. YUAN, Y. WANG, W.K. SILVERS
Journal: British Journal of Dermatology (1985)

The distribution of ATPase-positive Langerhans cells (LC) was investigated in 117 specimens of normal adult human skin and mucosa taken from different areas of the body. Although there were significant variations in the numbers of LC in each area examined, skin from the face and neck contained the highest density of cells (976 +/- 30.93/mm2). The densities of LC in trunk skin (740 +/- 28.97/mm2), scalp (693 +/- 69.56/mm2) and arm or leg skin (640 +/- 40.95/mm2) were similar. Buccal mucosa had significantly fewer LC (567 +/- 42.94/mm2) than trunk skin, and sacrococcyx skin and palm and sole skin displayed the smallest number of these cells (267 +/- 56.14/mm2 and, 189 +/- 19.15/mm2 respectively). No ATPase-positive LC were detected in the centre of two corneal specimens.