tbuckley/cabot-search huggingface dataset:
Depression and Primary Care
Authors: Harold Alan Pincus
Journal: Annals of Internal Medicine (1997)

Letters15 October 1997Depression and Primary CareHarold Alan Pincus, MD and Herbert Sacks, MDHarold Alan Pincus, MDAmerican Psychiatric Association; Washington, DC 20005American Psychiatric Association; Washington, DC 20005Search for more papers by this author and Herbert Sacks, MDAmerican Psychiatric Association; Washington, DC 20005American Psychiatric Association; Washington, DC 20005Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-8_Part_1-199710150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Kroenke, in his recent editorial [1], clearly and sensitively lays out the crux of the issue of the role of primary care physicians in diagnosing and treating depression. On the one hand, depression is common, costly, and disabling; it is also poorly detected and treated in primary care settings. On the other hand, the diagnosis of depression, particularly in persons with comorbid general medical conditions, is complex, takes time, and often requires more frequent observation and follow-up. Recognizing and treating depression in primary care is also complicated by the fact that primary care physicians have many ...References1. Kroenke K. Discovering depression in medical patients: reasonable expectations [Editorial]. Ann Intern Med. 1997; 126:463-5. Google Scholar2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Primary Care Version. Washington, DC: American Psychiatric Assoc; 1995. Google Scholar3. Pincus HA, McQueen LE. US primary care training in mental health and the role of the DSM-IV Primary Care Version (DSM-IV-PC). Primary Care Psychiatry. 1996; 2:139-54. Google Scholar4. Pincus HA, Strain JJ, Houpt JL, Gise LH. Models of mental health training in primary care. JAMA. 1983; 249:3065-8. Google Scholar5. Cole SA, Sullivan M, Kathol R, et al. A model curriculum for mental disorders and behavioral problems in primary care. Gen Hosp Psychiatry. 1995; 17:13-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Harold Alan Pincus, MD; Herbert Sacks, MDAffiliations: American Psychiatric Association; Washington, DC 20005American Psychiatric Association; Washington, DC 20005 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1997Volume 127, Issue 8_Part_1Page: 654 ePublished: 15 August 2000 Issue Published: 15 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cardiac impairment or heart failure?: Time for total political correctness?
Authors: Simon Carley, Bernard A Foëx
Journal: BMJ (2005)

The release of the government's latest report on health inequalities on 11 August was curious. 1 2 Reminiscent of the covert release of the Black report on August bank holiday in 1980, the report appeared when the minister for public health was on holiday and her deputy unavailable. Personal trainersIn July 2003 the government stated that there would be an annual report from the Department of Health on health inequality indicators related to the health inequality targets.Nothing appeared for more than two years, although the data that were eventually released had been available for some time, 3 and when they did appear it was, conveniently, after the election.Even stranger, the press release for the latest report deflected attention from the key finding of widening inequalities in life expectancy and infant mortality by headlining the 12 "early adopter sites" with their "health trainers." 4 The minister said, "Many people have difficulty in changing to a healthier way of life . . .Health trainers are one of the many initiatives in the white paper which will help narrow this gap by supporting people to make healthier choices in their daily lives." 4 To Labour traditionalists, opposed to victim blaming approaches to health promotion, this may have triggered memories of Conservative minister Edwina Currie admonishing the poor to buy cheap but healthy food.To New Labour, however, it may be grist to the mill.
Biochemistry of Human Cancer
Authors: Henry M. Lemon, Burnham S. Walker, M. Moira Davison Reynolds, Herbert H. Wotiz
Journal: New England Journal of Medicine (1954)

THE medieval alchemist tried to transmute base metals to gold without essential knowledge of the laws of physics and chemistry, and hence failure was his lot, although popular fancy long sustained such efforts. With the prerequisite basic knowledge, transmutation of the elements today is commonplace, and of ever-increasing importance. The search for a cure for cancer, before an understanding of mechanisms controlling cell growth and the integration of cell populations has been achieved, bears an obvious analogy. The 5031 recorded trials of antitumor agents in lower species show the limitations of the random chemotherapeutic approach to cancer control.1 , 2 In this . . .
GMC rules against doctor who used unconventional tests and treatments for chronic fatigue syndrome
Authors: C. Dyer
Journal: BMJ (2011)

A GP who diagnosed an infection similar to Lyme disease in patients with chronic fatigue syndrome adopted an “unwavering mindset” that ignored mainstream medicine, a General Medical Council fitness to practise panel has said.

The panel decided that Andrew Wright’s fitness to practise was impaired, despite his recantation and his resolution to practise only evidence based medicine in future. The sanction to be imposed will be decided at a later date.

Dr Wright ran a private practice in Bolton, Lancashire, specialising in the management of fatigue disorders from 2003 to 2006. He faced …
Experience with transjugular liver biopsy.
Authors: H J Bull, I T Gilmore, R D Bradley, J H Marigold, R P Thompson
Journal: Gut (1983)

The results of 193 transjugular liver biopsies performed with a modified needle are described. An adequate specimen was obtained in 97%, and complications were rare, although puncture of the liver capsule does occur and caused bleeding in two patients. Fever after the procedure was reduced by ultrasonic cleaning of the needle. Although not easy, this technique is safe and preferable in the management of selected patients, but in most patients percutaneous biopsy is to be preferred.
Basic and Clinical Studies of Endorphins
Authors: WILLIAM E. BUNNEY
Journal: Annals of Internal Medicine (1979)

Humans have used opium extracts since antiquity, studied its purified active ingredient, morphine, for over a century, and directly demonstrated its receptors in brain only 6 years ago, and even more recently discovered the brain's own morphine. These endogenously produced opiate peptides have sparked an increase in information, creating a new area of neuroscience. Much excitement has greeted the opening of basic and clinical investigative corridors, influencing the course of research into addiction, pain, stress, and psychiatric illness. We review basic work concerning opiate receptors and the endogenously produced opioid peptides, possible cellular mechanisms for addiction, involvement of endorphins in the action of antipsychotic drugs, the role of endorphins in pain modulation, and studies of endorphins in normal subjects and psychiatric patients.
Abstract 2105: Regulation of estrogen receptor turnover by lysine 302 methylation
Authors: Elizabeth L. Zoeller, Dalia Barsyte-Lovejoy, Peter J. Brown, Dafydd R. Owen, Cheryl H. Arrowsmith, Paula M. Vertino
Journal: Cancer Research (2014)

Abstract The estrogen pathway promotes growth of breast cancer, the leading cancer diagnosis among US women. The antiestrogen therapy Tamoxifen has been the mainline therapy for the 70% of women whose tumors are estrogen receptor alpha (ERα) positive for over thirty years. Understanding how ERα is regulated, particularly in the context of Tamoxifen, is essential for the treatment of breast cancer. In previous work, we showed that SetD7 mediated methylation of ERα at lysine 302 (K302) is a key mediator of estrogen receptor alpha stability. Downregulation of SetD7 or mutation of K302 increased the rate of ERα turnover resulting in a compromised estrogen driven transcriptional response. However, the precise mechanism by which lysine 302 methylation regulates ERα stability and transcriptional activity is not yet known. In this study, we used a novel small molecule inhibitor of SetD7, (R)-PFI-2, as a chemical probe to further investigate the role of K302 methylation in the regulation of ERα. Treatment of ERα expressing MCF7 breast cancer cells with (R)-PFI-2 resulted in a dose-dependent shift in the 66kDa ERα species to a slower migrating form as detected by protein electrophoresis and immunoblotting. Molecular mass estimates of this slower migrating form are consistent with a sumoylation event. Interestingly, (R)-PFI-2-induced accumulation of the slower migrating form was only observed upon inhibition of the proteasome with MG132, suggesting that this alternately modified form of ERα represents an intermediate in the pathway to degradation. A similar time-dependent shift to the same slower migrating form was observed upon estrogen depletion of MCF7 cells stably knocked down for SetD7, but not in control cells. Furthermore, an inverse relationship was observed between endogenous levels of SetD7 and the levels of modified ER in two strains of MCF7 cell line that differ in their sensitivity to Tamoxifen. These data suggest that methylation of ERα at K302 by SetD7 may stabilize ERα by blocking another post-translational modification, possibly sumoylation, necessary for its turnover. The relationship between ER methylation, sumoylation and Tamoxifen sensitivity will be discussed. Citation Format: Elizabeth L. Zoeller, Dalia Barsyte-Lovejoy, Peter J. Brown, Dafydd R. Owen, Cheryl H. Arrowsmith, Paula M. Vertino. Regulation of estrogen receptor turnover by lysine 302 methylation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2105. doi:10.1158/1538-7445.AM2014-2105
STUDIES ON THE EXTRACELLULAR CULTIVATION OF AN INTRACELLULAR PARASITE (AVIAN MALARIA)
Authors: William Trager
Journal: The Journal of Experimental Medicine (1950)

The erythrocytic stages of Plasmodium lophurae were freed from their host red cells by specific hemolysis directly into a favorable medium containing an extract of duck erythrocytes. Extracellular survival and development of the parasite in vitro occurred in culture media consisting essentially of a very concentrated extract of duck red cells prepared in a special nutrient solution. Omission or dilution of the red cell extract resulted in rapid degeneration of the parasites. Their survival and development were favored by the presence in the erythrocyte extract of gelatin, yeast adenylic acid, and cozymase, and especially by the further addition of adenosinetriphosphate and sodium pyruvate. Under the best conditions yet tested, all the free parasites continued their development extracellularly during the first two days of cultivation. Merozoites formed by the extracellular segmentation of the free parasites originally present developed further into trophozoites. On the third day a majority of the free parasites were still of normal appearance, but by the fourth day more were degenerate, and very few normal parasites remained on the fifth day.
Hazard of Video Games in Patients With Light-Sensitive Epilepsy
Authors: Neil R. Dahlquist
Journal: JAMA (1983)

VIDEO games have become an epidemic form of amusement. Recently, two reports appeared from England of patients with epilepsy in whom playing video games precipitated seizures<sup>1,2</sup>(<i>Time</i>, July 19, 1982, p 67). To emphasize the particular hazard of video games for susceptible persons with light-sensitive epilepsy, we herein document the first record, to our knowledge, of a similar case in the United States. <h3>Report of a Case</h3> A 15-year-old boy played video games for one year before his first seizure. He had no medical problems until March 7, 1982. While the boy played an electronic game called "Combat," a friend noted that he acted as if he were in a daze and that his hand was twitching. When he returned home shortly thereafter, his mother noticed that he had lost his glasses, that he was "belligerent for the first time in his life," and that his mentation was slow.
Colorectal Cancer at a Public Health Center
Authors: Robert S. Bobrow
Journal: JAMA (1987)

<h3>To the Editor.—</h3> At a public, outpatient health center, we introduced rigid sigmoidoscopy as part of routine medical care for a population that previously had had little access to such screening. Our center is freestanding and tax supported, with a sliding fee scale, and no one is denied care because of inability to pay. Patients come for checkups or because of illnesses, and rigid sigmoidoscopy was offered to anyone over the age of 50 years who was a potential surgical candidate. Patients had to make a separate appointment for the sigmoidoscopy; a digital rectal examination and a stool guaiac test were done as part of routine examinations. <h3>Study.—</h3> Preparation for the examination included a Fleet enema done by the patient at home just before leaving. At the examination, a guaiac test was done via digital rectal examination (if stool was present) and again after the sigmoidoscope had been inserted as
ENOXAPARIN COMPARED WITH UNFRACTIONATED HEPARIN IN THE PHARMACOINVASIVE MANAGEMENT OF ST ELEVATION MYOCARDIAL INFARCTION: INSIGHTS FROM THE TRANSFER-AMI TRIAL
Authors: Shaun G. Goodman, Warren J. Cantor, Bjug Borgundvaag, David Fitchett, Vladimir Dzavik, John Ducas, Michael Heffernan, Eric A. Cohen, Andrew T. Yan, Shahar Lavi
Journal: Journal of the American College of Cardiology (2011)
NLRP3-Deficient Mice Have an Enhanced Neutrophil Apoptosis and a Suppressed Inflammatory Response to Hyperoxia-Induced Acute Lung Injury
Authors: Jutaro Fukumoto, Itsuko Fukumoto, Bao Huynh, Ruan R. Cox, Prasanna Tamarapu Parthasarathy, Gurukumar Kollongod Ramanathan, Rajan Babu Venugopal, Richard F. Lockey, Narasaiah Kolliputi
Journal: Journal of Allergy and Clinical Immunology (2013)
Comedication related to comorbidities: a study in 1203 hospitalized patients with severe psoriasis
Authors: S. Gerdes, V.A. Zahl, H. Knopf, M. Weichenthal, U. Mrowietz
Journal: British Journal of Dermatology (2008)

Background Psoriasis is a common dermatological disorder characterized by an immune-mediated chronic inflammation which is associated with a variety of other diseases commonly referred to as comorbidities. The treatments for these diseases may interfere with the course and the treatment of psoriasis. Little is known on the general drug intake of patients with psoriasis. Objectives To gain more insight into the general drug intake of patients with severe psoriasis. A correlation of comedication to respective diseases could lead to a better knowledge of comorbidities. Methods Data on demographics, comedication and comorbidities from 1203 patients with severe psoriasis in Germany were analysed. As a control group data from 7099 subjects from the German National Health Survey 1998 were used. Results Patients with severe psoriasis are receiving significantly more different systemic drugs on average than the general population, with the most prominent difference in multidrug treatment. Drugs used in the treatment of arterial hypertension, diabetes mellitus and other diseases of the metabolic syndrome as well as oral anticoagulants and anticonvulsant agents showed the greatest differences. Special characteristics of antihypertensive drug treatments could be determined. Conclusions The data obtained in this study provide the basis for an improved management of patients with psoriasis. Knowledge of existing comedication and comorbidities may lead to the ability to treat psoriasis and comorbidities at the same time more safely and to use possible synergistic effects.
Infarction After Anesthesia
Authors: Robert M. Jeresaty
Journal: JAMA (1972)

To the Editor.—  Relative to the three points raised by Dr. Jeresaty, we comment as follows. In one instance an incorrect statement was made  we thank him for pointing it out. In the other two instances, whether they are misleading or not depends upon the interpretation; in each we make one point; he makes a different one from the same data. Both are correct.  First, the mistake: About one third of patients having a myocardial infarction... died in the first 48 hours. This statement from Shapiro et al is correct, as Dr. Jeresaty points out,  was in the original manuscript. Somewhere in the processing, the words and reaching the hospital were added, which makes the whole sentence incorrect. This addition was not detected by us before publication, for which we apologize.  Point two: Fifty-four percent of our patients who had previous myocardial infarctions died as a result of
Molecular changes in the offspring of liquidators who emigrated to Israel from the Chernobyl disaster area.
Authors: H S Weinberg, E Nevo, A Korol, T Fahima, G Rennert, S Shapiro
Journal: Environmental Health Perspectives (1997)

The primary goal of this research was to reveal de novo mutations in the liquidators (cleanup personnel) who emigrated to Israel from the Chernobyl disaster area. We used genome fingerprinting simple sequence repeat-anchored polymerase chain reaction (PCR) amplification and random amplified polymorphic DNA PCR (RAPD PCR). The methodology involved a combination of RAPD PCR, polyacrylamide gel electrophoresis, and silver staining, with arbitrarily primed PCR. Use of microsatellite markers appears to be the most promising technique for high sensitivity analysis. The analysis involved DNA isolated from the blood of experimental and control subjects (involving both offspring who were born before or after the disaster and their parents). Our studies have reproducibly detected new bands that appeared in the children born after the disaster. No such bands appeared in the children born in the same family before the accident or in the children of control families who had not been exposed to radiation.
901-99 “The 60-Minutes Myocardial Infarction Project”: Lower Rate of Diagnostic ECG on Admission, Shorter Prehospital Delay and Increased Door-to-Needle-Time in Patients with Acute Reinfarction
Authors: Jörg Rustige, Caroline Bergmeier, Matthias Arens, Rudolf Schiele, Udo Burczyk, Martin Gottwik, Jochen Senges, Armin Koch
Journal: Journal of the American College of Cardiology (1995)
Allografting in patients with severe, refractory aplastic anemia using peripheral blood stem cells and a fludarabine-based conditioning regimen: The Mexican experience
Authors: David Gómez-Almaguer, Jorge Vela-Ojeda, José C. Jaime-Pérez, César H. Gutiérrez-Aguirre, Olga G. Cantú-Rodríguez, Pedro Sobrevilla-Calvo, Silvia Rivas-Vera, J. David Gómez-Rangel, Guillermo J. Ruiz-Argüelles
Journal: American Journal of Hematology (2006)

We studied the effectiveness of a fludarabine/cyclophosphamide-based conditioning regimen without anti-thymocyte globulin in 23 aplastic anemia patients who had no response to previous conventional pharmacologic treatment. Patients received oral busulphan 4 mg/kg/day/2 days, IV cyclophosphamide 350 mg/m(2)/day/3 days, and fludarabine 30 mg/m(2)/day/3 days. For GVHD prophylaxis, patients received MTX 5 mg/m(2) days +1, +3, +6, and +11 and oral cyclosporin A (CyA) 5 mg/kg/day, starting on day -1. Peripheral blood stem cell products were used with a median dose of 5.5 x 10(6) CD34(+)/kg. The patients were followed for an average of 25 months. By a median of day +11, an ANC > 0.5 x 10(9)/L was reached; and by day +12, the platelet count had reached >20,000 x 10(9)/L. Acute grade I-II GVHD occurred in 4 patients, whereas limited chronic GVHD presented in 6 cases. Twenty-one patients (91.3%) achieved engraftment. Two patients failed to engraft, and 4 developed late rejection; 2 of these individuals died, 2 have survived with high transfusion requirements, whereas 2 received a second peripheral blood stem cell infusion and achieved sustained engraftment. Currently 21 (91%) of the 23 patients are alive, whereas 19 of 21 (90%) remain in complete remission. The average cost was about USD 15,000 for this kind of reduced-intensity allotransplant. Reduced-intensity stem cell transplantation represents an affordable alternative to traditional more cytotoxic conditioning for severe aplastic anemia (SAA) patients. Long-term effects however, remain to be evaluated.
The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domain.
Authors: K A Cooney, W C Nichols, M E Bruck, W F Bahou, A D Shapiro, E J Bowie, H R Gralnick, D Ginsburg
Journal: Journal of Clinical Investigation (1991)

Type IIB von Willebrand Disease (vWD) is characterized by the selective loss of large von Willebrand Factor (vWF) multimers from plasma, presumably due to their increased reactivity with platelets and subsequent clearance from the circulation. Using the PCR, one of a panel of four potential missense mutations was identified in each of the 14 patients studied from 11 unrelated families. None of these substitutions was encountered in a large panel of normal DNAs. These changes all represent C----T transitions at CpG dinucleotides, proposed "hot spots" for mutation in the human genome. The four resulting amino acid substitutions, Arg543----Trp, Arg545----Cys, Val553----Met, and Arg578----Gln, are all clustered within the GpIb binding domain of vWF. Disruption of this latter functional domain may explain the pathogenesis of Type IIB vWD. By sequence polymorphism analysis, the Arg543----Trp substitution was shown to have occurred as at least two independent mutational events. This latter observation, along with the identification of mutations in all 14 patients studied and their localization to the GpIb binding domain, all strongly suggest that these substitutions represent the authentic defects responsible for Type IIB vWD. This panel of mutations may provide a useful diagnostic tool for the majority of patients with Type IIB vWD.
IMMUNOGLOBULIN SYNTHESIS IN MICE
Authors: Leonore A. Herzenberg, Leonard A. Herzenberg, Robert C. Goodlin, Edna C. Rivera
Journal: The Journal of Experimental Medicine (1967)

In the mouse, antibody directed against an immunoglobulin allotype, Ig-1b, passed from mother to offspring or injected into neonates, suppresses synthesis of immunoglobulin carrying Ig-1b. In allotype homozygotes as well as heterozygotes the allotype suppression is manifested both by a delay of several weeks in attaining initial detectable allotype levels and a reduction in allotype level continuing into adulthood. A possible mechanism for the differentiation of the immune system consistent with both the kinetics of suppression reported here for the mouse and the comparatively longer lived and more complete allotype suppression described for the rabbit is discussed. Evidence for a strong intralitter (as opposed to interlitter) correlation of age of onset of immunoglobulin allotype synthesis is presented.