tbuckley/cabot-search huggingface dataset:
Microcomputer Simulation for Interviewing
Authors: JON D. HODGIN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 May 1984Microcomputer Simulation for InterviewingJON D. HODGIN, M.D.JON D. HODGIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-5-764_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Lipkin and colleagues (1) on designing a core curriculum for the medical interview in residency training correctly addresses the interview as encompassing the complete physician/patient interaction as a progressive interpersonal relationship. Putting residents in touch with the emotional nuances of the physician's approach to the patient has long been a most difficult task for psychiatric training (2). This lesson is usually taught through individual supervision by faculty members, a method that, although effective, is not time efficient.The authors also briefly address the passive/active continuum that exists in all teaching modes, the main...References1. LIPKINQUILLNAPODANO MTR. The medical interview: a core curriculum for residencies in internal medicine. Ann Intern Med. 1984;100:277-48. LinkGoogle Scholar2. FORD E. Being and becoming a psychiatrist: the search for identity. Am J Psychother. 1963;17:472-82. CrossrefMedlineGoogle Scholar3. ROESKE N. The medium and the message: development of videotapes for teaching psychiatry. Am J Psychiatry. 1979;136:1391-7. CrossrefMedlineGoogle Scholar4. CORRADIWASMANGOLD RMF. Teaching about transference: a videotape introduction. Am J Psychother. 1980;34:564-71. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JON D. HODGIN, M.D.Affiliations: J. Hillis Miller Health Center University of Florida Gainesville, FL 32610 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1984Volume 100, Issue 5Page: 764-765KeywordsEmotionsResidencyTouch ePublished: 1 December 2008 Issue Published: 1 May 1984 PDF downloadLoading ...
Basic calcium phosphate crystals activate human osteoarthritic synovial fibroblasts and induce matrix metalloproteinase-13 (collagenase-3) in adult porcine articular chondrocytes
Authors: G M McCarthy, P R Westfall, I Masuda, P A Christopherson, H S Cheung, P G Mitchell
Journal: Annals of the Rheumatic Diseases (2001)

<h3>OBJECTIVE</h3> To determine the ability of basic calcium phosphate (BCP) crystals to induce (<i>a</i>) mitogenesis, matrix metalloproteinase (MMP)-1, and MMP-13 in human osteoarthritic synovial fibroblasts (HOAS) and (<i>b</i>) MMP-13 in cultured porcine articular chondrocytes. <h3>METHODS</h3> Mitogenesis of HOAS was measured by [<sup>3</sup>H]thymidine incorporation assay and counts of cells in monolayer culture. MMP messenger RNA (mRNA) accumulation was determined either by northern blot analysis or reverse transcriptase-polymerase chain reaction (RT-PCR) of RNA from chondrocytes or HOAS treated with BCP crystals. MMP-13 secretion was identified by immunoprecipitation and MMP-1 secretion by western blot of conditioned media. <h3>RESULTS</h3> BCP crystals caused a 4.5-fold increase in [<sup>3</sup>H]thymidine incorporation by HOAS within 20 hours compared with untreated control cultures (p⩽0.05). BCP crystals induced MMP-13 mRNA accumulation and MMP-13 protein secretion by articular chondrocytes. In contrast, in HOAS, MMP-13 mRNA induced by BCP crystals was detectable only by RT-PCR, and MMP-13 protein was undetectable. BCP crystals induced MMP-1 mRNA accumulation and MMP-1 protein secretion by HOAS. MMP-1 expression was further augmented when HOAS were co-incubated with either BCP and tumour necrosis factor α (TNFα; threefold) or BCP and interleukin 1α (IL1α; twofold). <h3>CONCLUSION</h3> These data confirm the ability of BCP crystals to activate HOAS, leading to the induction of mitogenesis and MMP-1 production. MMP-13 production in response to BCP crystals is substantially more detectable in porcine articular chondrocytes than in HOAS. These data support the active role of BCP crystals in osteoarthritis and suggest that BCP crystals act synergistically with IL1α and TNFα to promote MMP production and subsequent joint degeneration.
The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands
Authors: R. L. ATTANOOS, M. A. C. APPLETON, A. G. DOUGLAS-JONES
Journal: British Journal of Dermatology (1995)

We undertook a retrospective pathological study of 118 skin resection specimens from 101 patients with hidradenitis suppurativa. Follicular occlusion was identified in all the specimens, regardless of disease duration (1 month to 18 years), but was not noted in the axillary and inguinal skin of controls. We therefore regard follicular occlusion as an early and important feature in the pathogenesis of the disease. The presence of apoeccrine glands in axillary skin provided an in vivo model to directly observe the effects of follicular occlusion on follicle inflammation and apocrine gland destruction. In the majority of cases, active folliculitis was associated with apocrinitis and apocrine destruction, whereas apoeccrine glands, which drain directly on to the epidermal surface, appeared intact and non‐intlamed. These observations provide direct evidence in an in vivo model that follicular occlusion by keratinous material, with subsequent active folliculitis and secondary destruction of the skin adnexae and subcutis, occur as an integral step in the pathogenesis of hidradenitis suppurativa.
Morning Cortisol Levels and Cognitive Abilities in People With Type 2 Diabetes
Authors: Rebecca M. Reynolds, Mark W.J. Strachan, Javier Labad, Amanda J. Lee, Brian M. Frier, F. Gerald Fowkes, Rory Mitchell, Jonathan R. Seckl, Ian J. Deary, Brian R. Walker, Jackie F. Price
Journal: Diabetes Care (2010)

OBJECTIVE People with type 2 diabetes are at increased risk of cognitive impairment but the mechanism is uncertain. Elevated glucocorticoid levels in rodents and humans are associated with cognitive impairment. We aimed to determine whether fasting cortisol levels are associated with cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes. RESEARCH DESIGN AND METHODS This was a cross-sectional study of 1,066 men and women aged 60–75 years with type 2 diabetes, living in Lothian, Scotland (the Edinburgh Type 2 Diabetes Study). Cognitive abilities in memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility were tested, and a general cognitive ability factor, g, was derived. Prior intelligence was estimated from vocabulary testing, and adjustment for scores on this test was used to estimate lifetime cognitive change. Relationships between fasting morning plasma cortisol levels and cognitive ability and estimated cognitive change were tested. Models were adjusted for potential confounding and/or mediating variables including metabolic and cardiovascular variables. RESULTS In age-adjusted analyses, higher fasting cortisol levels were not associated with current g or with performance in individual cognitive domains. However, higher fasting cortisol levels were associated with greater estimated cognitive decline in g and in tests of working memory and processing speed, independent of mood, education, metabolic variables, and cardiovascular disease (P &amp;lt; 0.05). CONCLUSIONS High morning cortisol levels in elderly people with type 2 diabetes are associated with estimated age-related cognitive change. Strategies targeted at lowering cortisol action may be useful in ameliorating cognitive decline in individuals with type 2 diabetes.
Woven Into the Plot
Authors: Jed Myers
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasmacytoma of the Ovary
Authors: Sampath Santhosh, Bhagwant Rai Mittal, Ainharan Raveendran, Vanita Jain, Raje Nijhawan, Ritesh Kumar, Anish Bhattacharya, Suresh C. Sharma
Journal: Clinical Nuclear Medicine (2013)

We report a case of ovarian plasmacytomas where 18F-FDG PET/CT helped in staging by demonstrating increased FDG uptake limited to the ovary, and hence, surgical treatment was carried out as the disease was localized to the ovary.
Bile Acid Content of Human Serum. II. The Binding of Cholanic Acids by Human Plasma Proteins1
Authors: Daniel Rudman, Forrest E. Kendall
Journal: Journal of Clinical Investigation (1957)

Although many observations indicate that bile acids and their derivatives may be bound by serum proteins, little information upon the quantitative aspects of this reaction is available.Lecomte du Nofiy (1) observed that the activity of bile salts
Management in primary care
Authors: W. S. Lim, M. L. Levy, J. T. Macfarlane
Journal: BMJ (2010)

Mandell raises some concerns about the primary care summary of the 2009 British Thoracic Society (BTS) guidelines on managing community acquired pneumonia in adults.1 2

The main focus of the BTS guidelines is the management of radiographically confirmed pneumonia in hospital.3 Nevertheless, a summary of information relevant to primary care was considered to be of interest to …
Augmentation of Radiation Response by Motesanib, a Multikinase Inhibitor that Targets Vascular Endothelial Growth Factor Receptors
Authors: Tim J. Kruser, Deric L. Wheeler, Eric A. Armstrong, Mari Iida, Kevin R. Kozak, Albert J. van der Kogel, Johan Bussink, Angela Coxon, Anthony Polverino, Paul M. Harari
Journal: Clinical Cancer Research (2010)

Motesanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, platelet-derived growth factor receptor, and Kit receptors. In this report we examine the interaction between motesanib and radiation in vitro and in head and neck squamous cell carcinoma (HNSCC) xenograft models.In vitro assays were done to assess the impact of motesanib on VEGFR2 signaling pathways in human umbilical vein endothelial cells (HUVEC). HNSCC lines grown as tumor xenografts in athymic nude mice were utilized to assess the in vivo activity of motesanib alone and in combination with radiation.Motesanib inhibited VEGF-stimulated HUVEC proliferation in vitro, as well as VEGFR2 kinase activity. Additionally, motesanib and fractionated radiation showed additive inhibitory effects on HUVEC proliferation. In vivo combination therapy with motesanib and radiation showed increased response compared with drug or radiation alone in UM-SCC1 (P < 0.002) and SCC-1483 xenografts (P = 0.001); however, the combination was not significantly more efficacious than radiation alone in UM-SCC6 xenografts. Xenografts treated with motesanib showed a reduction of vessel penetration into tumor parenchyma, compared with control tumors. Furthermore, triple immunohistochemical staining for vasculature, proliferation, and hypoxia showed well-defined spatial relationships among these parameters in HNSCC xenografts. Motesanib significantly enhanced intratumoral hypoxia in the presence and absence of fractionated radiation.These studies identify a favorable interaction when combining radiation and motesanib in HNSCC models. The data presented suggest that motesanib reduces blood vessel penetration into tumors and thereby increases intratumoral hypoxia. These findings suggest that clinical investigations examining combinations of radiation and motesanib are warranted in HNSCC.
Multiple tendon rupture in systemic lupus erythematosus: case report and review of the literature.
Authors: I Potasman, H M Bassan
Journal: Annals of the Rheumatic Diseases (1984)

Tendon rupture in systemic lupus erythematosus (SLE) is a rare complication that appears to occur in patients receiving corticosteroid therapy. A case is presented with sequential bilateral rupture of Achilles tendon and unilateral rupture of a patellar tendon. Six more published cases are reviewed. Tendon rupture in SLE has affected both males and females between the ages of 24 and 63 years. It occurred exclusively in the weight-bearing tendons: in 6 instances the patellar tendon was severed, in 2 the Achilles, and in one the quadriceps. All 7 patients were on corticosteroid therapy at or just before the time of injury. The deleterious effect of this treatment in loosening connective tissue is discussed.
Outcome Predictors in Anorectic Patients after 6 Months of Multimodal Treatment
Authors: S. Fassino, G. Abbate Daga, F. Amianto, P. Leombruni, B. Fornas, L. Garzaro, G. D’Ambrosio, G.G. Rovera
Journal: Psychotherapy and Psychosomatics (2001)

Anorexia nervosa is a severe disorder that often responds poorly to treatment. At this time, little is known about pretreatment predictors of response.A sample of 42 restrictor type anorectics was tested at the assessment phase and after 180 days retested using the Temperament and Character Inventory and Eating Disorder Inventory 2 along with other clinical evaluation instruments. After 180 days of treatment with multimodal 'network' therapy, the patients were divided into two groups. The first group included patients who showed relevant clinical improvement; the second group included patients considered 'not yet responding'. Data collected from the not-yet-responding group were compared by the t test with the other group's data to evaluate prognostic indexes.Diagnosis of personality disorder, which afflicted about 50% of patients, seemed not to be a relevant prognostic factor. However, a lower novelty seeking was characteristic of the nonresponder group. Higher levels of asceticism and maturity fears also characterized the nonresponder group.Present data suggest some elements that could be useful to focus pharmacotherapy, psychotherapy and family counseling on the current psychopathology of each patient.
The clinical features of HIV infection in Africa.
Authors: R J Biggar
Journal: BMJ (1986)

In general available information indicates that the course of AIDS is similar in Africa to the  seen in the developing world.  Clinical features of the active  may differ however given the local environments and pathogens to which Africans are exposed.  It takes several years for a person with HIV antibodies to gradually lose their cell-mediated immunity and manifest acute seroconversion syndrome of encephalitis asymptomatic immunodepression (low numbers of T helper cells) generalized lymphadenopathy Kaposis sarcoma cytomegalovirus and the less serious AIDS opportune infections such as oral candidiasis and herpes zoster.  One distinction between African and western AIDS  is less frequent Pneumocystis carinii pneumonia.  Conditions seen more often in African AIDS victims include toxoplasmosis and tuberculosis.  In contrast malaria helminths and African Burkitts lymphoma do not seem more prevalent among AIDS patients.  The pathogenesis of the wasting phenomenon known as slim disease in Uganda is unknown.  Kaposis sarcoma may be subject to regional variation:  it is more common in an area where the condition is endemic that overlaps with the belt of epidemic of AIDS through Zambia and Uganda.  Given the high incidence of seropositive young adults in Zaire Zambia Kenya and Rwanda who presumably contracted the virus from heterosexual contact only an effective vaccine will prevent a serious AIDS tragedy in the area.
PROSTATITIS OF NONVENEREAL ORIGIN
Authors: THEODORE BAKER
Journal: JAMA (1925)

By prostatitis—including seminal vesiculitis—of nonvenereal origin, I mean prostatitis in which the gonococcus can be eliminated as a causative agent.  Although this form of prostatitis has long been recognized by urologists, there seems to be a general lack of understanding regarding its nature and frequency.  The importance of its recognition lies in the fact that it may be, and indeed frequently is, mistaken for a gonorrheal infection, even though the gonococcus cannot be demonstrated. This is shown by the hesitation or frequent unwillingness of insurance companies, workmen's compensation boards and the Veterans' Bureau to grant indemnities for inflammatory diseases of these structures. The disaster that such a mistake in diagnosis may cause to a man's domestic happiness need only be mentioned. Furthermore, the mental anxiety, often leading to marked depression, which many patients, absolutely innocent, are made to suffer by the impression that they have a disgraceful ailment, is not
Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload
Authors: Norimichi Koitabashi, Thomas Danner, Ari L. Zaiman, Yigal M. Pinto, Janelle Rowell, Joseph Mankowski, Dou Zhang, Taishi Nakamura, Eiki Takimoto, David A. Kass
Journal: Journal of Clinical Investigation (2011)

The cardiac pathological response to sustained pressure overload involves myocyte hypertrophy and dysfunction along with interstitial changes such as fibrosis and reduced capillary density. These changes are orchestrated by mechanical forces and factors secreted between cells. One such secreted factor is TGF-β, which is generated by and interacts with multiple cell types. Here we have shown that TGF-β suppression in cardiomyocytes was required to protect against maladaptive remodeling and involved noncanonical (non-Smad-related) signaling. Mouse hearts subjected to pressure overload and treated with a TGF-β-neutralizing Ab had suppressed Smad activation in the interstitium but not in myocytes, and noncanonical (TGF-β-activated kinase 1 [TAK1]) activation remained. Although fibrosis was greatly reduced, chamber dysfunction and dilation persisted. Induced myocyte knockdown of TGF-β type 2 receptor (TβR2) blocked all maladaptive responses, inhibiting myocyte and interstitial Smad and TAK1. Myocyte knockdown of TβR1 suppressed myocyte but not interstitial Smad, nor TAK1, modestly reducing fibrosis without improving chamber function or hypertrophy. Only TβR2 knockdown preserved capillary density after pressure overload, enhancing BMP7, a regulator of the endothelial-mesenchymal transition. BMP7 enhancement also was coupled to TAK1 suppression. Thus, myocyte targeting is required to modulate TGF-β in hearts subjected to pressure overload, with noncanonical pathways predominantly affecting the maladaptive hypertrophy/dysfunction.
Attempted Suicide by Drug Anaphylaxis
Authors: John Ruskin
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The letter by Dr. Bryce Templeton of Pittsburgh in the April 19, 1965, issue ofThe Journal(<b>192</b>:164) was quite interesting to me. Recently I had a patient, a young white woman in her twenties, who knowing that she was extremely sensitive to the sulfonamides, in a suicide attempt took 12 tablets of a triple sulfa preparation which had been prescribed for her child by another physician. When she was seen by me her condition was best described as moribund, and she responded promptly to epinephrine administered intravenously. This is the only patient I personally have seen who attempted suicide by drug anaphylaxis. I hold it for indisputable, that the first duty of a State is to see that every child born therein shall be well housed, clothed, fed, and educated, till it attain years of discretion. But in order to the effecting this the Government
Modification of Biomaterials with a Self‐Protein Inhibits the Macrophage Response
Authors: Yoon Kyung Kim, Richard Que, Szu‐Wen Wang, Wendy F. Liu
Journal: Advanced Healthcare Materials (2014)

A biomaterial inhibits the host immune response by displaying an endo­genously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Exposure and Participant Modelling in a Case of Injection Phobia
Authors: Rutger W. Trijsburg, Marko Jelicic, Walter W. van den Broek, Annelies E.M. Plekker, Rene Verheij, Jan Passchier
Journal: Psychotherapy and Psychosomatics (1996)

Background: From the literature it appears that there may be two types of injection phobia, (1) the 'vasovagal' type, and (2) the 'resistant' type. The first type is characterized by a diphasic cardiovascular response during or after injection and by a tendency to react in a passive, nonresisting way when injected. The second type is characterized by strong, sometimes violent resistance and no vasovagal reaction to an injection. Characteristics of blood injury phobia apply to the first type, but not to the second. The possibility is considered that exposure may be an effective treatment in the first type, and participant modelling in the second type. Method: A single case study was carried out with a case of injection phobia of the second type in which exposure with modelling, followed by participant modelling of the injection, was applied. Measures of state anxiety (STAI) and heart rate were obtained. Results: According to expectation, participant modelling of injections was effective in eliminating the fear of injections in a patient of the second type of injection phobia. Conclusions: The results of this study warrant further investigation of the model in a group design in which the differential treatment effects of exposure and participant modelling are tested.
SOME RESULTS OBTAINED FROM THE LOCAL APPLICATION OF SOLID CARBON DIOXIDE
Authors: E. R. Morton
Journal: BMJ (1910)

CASE V.W. T., aged 10 years; hairy mole like a mouse, 11 in.long and i in.broad on left cheek (Fig. 4).Exposed piecemeal to the snow for five seconds on March 16th.A reaction occurred next day, followed by a marked improve-
Book Review Clinical Examination on CD-ROM With user's manual, 11 pp. By Owen Epstein, G. David Perkin, David P. de Bono, and John Cookson. System requirements: Multimedia IBM PC or compatible computer with 8 MB RAM. (Also available for Macintosh System 7.0 with 4 MB RAM.) St. Louis, Mosby, 1998. $69.95. 0-7234-2184-6
Authors: Daniel Mimouni, Eytan Z. Blumenthal
Journal: New England Journal of Medicine (1999)