Slow-Release Verapamil and Hyperglycemic Metabolic Acidosis
Authors: Arie Roth
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 January 1989Slow-Release Verapamil and Hyperglycemic Metabolic AcidosisArie Roth, MD, Hylton I. Miller, MB, Bernard Beihassen, MD, Shlomo Laniado, MDArie Roth, MDSearch for more papers by this author, Hylton I. Miller, MBSearch for more papers by this author, Bernard Beihassen, MDSearch for more papers by this author, Shlomo Laniado, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-2-171_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Verapamil hydrochloride, a calcium antagonist, has been widely used for more than 25 years as an antianginal (1) and antiarrhythmic drug (2). Reports of verapamil's side effects (3) and acute intoxication (4, 5) are few and include various neurologic, cardiovascular, and metabolic derangements.Slow-release verapamil hydrochloride (Calan, Searle and Company, San Juan, Puerto Rico) has been recently marketed to replace divided doses of verapamil for patients' convenience. We report an acute adverse reaction to a single dose of slow-release verapamil in a patient after well-tolerated, long-term treatment with regular verapamil.A 66-year-old thin, nondiabetic white woman with...References1. Sandler G, Clayton G, and Thornicroft S. Clinical evaluation of verapamil in angina pectoris. Br Med J. 1968;3:224-7. CrossrefMedlineGoogle Scholar2. Shamroth L. Immediate effects of intravenous verapamil on atrial fibrillation. Cardiovasc Res. 1971;5:419-24. CrossrefMedlineGoogle Scholar3. Witchitz S, Haiat R, Tarrade T, and Chiche P. Accidents cardiovasculaires au cours des traitements par le verapamil. A propos de 6 observations. Nouv Presse Med. 1975;4:337-8. MedlineGoogle Scholar4. Moroni F, Mannaioni P, Dolara A, and Ciaccheri N. Calcium gluconate and hypertonic sodium chloride in a case of massive verapamil poisoning. Clin Toxicol. 1980;17:395-400. CrossrefMedlineGoogle Scholar5. Enyeart J, Price W, Hoffman D, and Woods L. Profound hyperglycemia and metabolic acidosis after verapamil overdose. J Am Coll Cardiol. 1983;2:1228-31. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Arie Roth, MD; Hylton I. Miller, MB; Bernard Beihassen, MD; Shlomo Laniado, MDAffiliations: Tel-Aviv Medical Center Sackler School of Medicine Tel-Aviv University Tel-Aviv 64239 Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced Hyperglycemia and Diabetes MellitusManagement of β-Adrenergic Blocker and Calcium Channel Antagonist ToxicityCalcium channel blocker overdoseBeneficial myocardial metabolic effects of insulin during verapamil toxicity in the anesthetized caninePyrazinoylguanidine Downregulates the Glucose Fatty-Acid Cycle in Hypertensive, Hyperinsulinemic Diabetic Patientsβ-Blocker and Calcium Channel Blocker ToxicityCase Report: Sustained-Release Verapamil Overdose Causing Stroke: An Unusual Complication8 Drug-induced diabetes 15 January 1989Volume 110, Issue 2Page: 171-172KeywordsAcidosisAdverse reactionsCalciumDrugsIntoxication ePublished: 1 December 2008 Issue Published: 15 January 1989 PDF downloadLoading ...