tbuckley/cabot-search huggingface dataset:
Argatroban Anticoagulant Therapy in Patients With Heparin-Induced Thrombocytopenia
Authors: B. E. Lewis, D. E. Wallis, S. D. Berkowitz, W. H. Matthai, J. Fareed, J. M. Walenga, J. Bartholomew, R. Sham, R. G. Lerner, Z. R. Zeigler, P. K. Rustagi, I. K. Jang, S. D. Rifkin, J. Moran, M. J. Hursting, J. G. Kelton
Journal: Circulation (2001)

Heparin-induced thrombocytopenia (HIT) is an immune-mediated syndrome caused by heparin. Complications range from thrombocytopenia to thrombocytopenia with thrombosis. We report a prospective, historical- controlled study evaluating the efficacy and safety of argatroban, a direct thrombin inhibitor, as anticoagulant therapy in patients with HIT or HIT with thrombosis syndrome (HITTS).Patients with HIT (isolated thrombocytopenia, n=160) or HITTS (n=144) received 2 microgram. kg(-1). min(-1) IV argatroban, adjusted to maintain the activated partial thromboplastin time 1.5 to 3.0 times baseline value. Treatment was maintained for 6 days, on average. Clinical outcomes over 37 days were compared with those of 193 historical control subjects with HIT (n=147) or HITTS (n=46). The incidence of the primary efficacy end point, a composite of all-cause death, all-cause amputation, or new thrombosis, was reduced significantly in argatroban-treated patients versus control subjects with HIT (25.6% versus 38.8%, P=0.014). In HITTS, the composite incidence in argatroban-treated patients was 43.8% versus 56.5% in control subjects (P=0.13). Significant between-group differences by time-to-event analysis of the composite end point favored argatroban treatment in HIT (P=0.010) and HITTS (P=0.014). Argatroban therapy, relative to control subjects, also significantly reduced new thrombosis and death caused by thrombosis (P<0.05). Argatroban-treated patients achieved therapeutic activated partial thromboplastin times generally within 4 to 5 hours of starting therapy and, compared with control subjects, had a significantly more rapid rise in platelet counts (P=0.0001). Bleeding events were similar between groups.Argatroban anticoagulation, compared with historical control subjects, improves clinical outcomes in patients who have heparin-induced thrombocytopenia, without increasing bleeding risk.
Mentality and Neurosis: Evolutionary Thinking in Cognitive Therapy
Authors: Reinhold Becker
Journal: Psychotherapy and Psychosomatics (1990)

Cognitive therapy includes a variety of methods. There are two main schools, a currently predominant American one, and an earlier European one. They give different emphasis to the concept of the evolution of human cognition. There is agreement on the particular significance of surmounting absolutist thinking.
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys
Authors: Tamio Yamaguchi, Shizuko Nagao, Darren P. Wallace, Franck A. Belibi, Benjamin D. Cowley, Jill C. Pelling, Jared J. Grantham
Journal: Kidney International (2003)
Can computer aided teaching packages improve clinical care in patients with acute abdominal pain?
Authors: F T de Dombal, V Dallos, W A McAdam
Journal: BMJ (1991)

OBJECTIVE--To compare three methods of support for inexperienced staff in their diagnosis and management of patients with acute abdominal pain--namely, with (a) structured data collection forms, (b) real time computer aided decision support, and (c) computer based teaching packages. DESIGN--Prospective assessment of effects of methods of support on groups of doctors in one urban hospital and one rural hospital. SETTING--Accident and emergency department at Whipps Cross Hospital, London, and surgical wards of Airedale General Hospital, West Yorkshire. PATIENTS--Consecutive prospective series of all patients presenting to each hospital in specified time periods with acute abdominal pain; total patients in the various periods were 12,506. MAIN OUTCOME MEASURES--Diagnostic accuracy of participating doctors, admission rates of patients with non-specific abdominal pain, perforation rates in patients with appendicitis, negative laparotomy rates. RESULTS--Use of any one modality resulted in improved diagnostic accuracy and decision making performance. Use of structured forms plus computer feedback resulted in better performance than use of forms alone. Use of structured forms plus a computer teaching package gave results at least as good as those with direct feedback by computer. CONCLUSIONS--The results confirm earlier studies in suggesting that the use of computer aided decision support improves diagnostic and decision making performance when dealing with patients suffering from acute abdominal pain. That use of the computer for teaching gave results at least as good as with its use for direct feedback may be highly relevant for those who are apprehensive about the real time use of diagnostic computers in a clinical setting.
Acquired Brown's syndrome in a patient with systemic lupus erythematosus.
Authors: J L Alonso-Valdivielso, B Alvarez Lario, J Alegre Lopez, M J Sedano Tous, A Buitrago Gomez
Journal: Annals of the Rheumatic Diseases (1993)

A 27 year old woman with systemic lupus erythematosus (SLE) developed vertical diplopia with an apparent bilateral inferior oblique muscle palsy, resulting in a limitation of elevation of the globe in adduction. It resolved with systemic steroid treatment. A transient tenosynovitis affecting the superior oblique tendons was the probable underlying pathological mechanism. This is the first described case of Brown9s syndrome associated with SLE.
Return of Susannah Sash Shandy
Authors: Robert J. Morgan
Journal: JAMA (1974)

<h3>To the Editor.—</h3> More on "Small Slam" (224:1414, 1973), or "Toilet Seat Syndrome" or "Shandy Syndrome" or "Window Sash Syndrome" or "Susannah Sash Syndrome" or "The Seat of the Commode Fell Down on His Bleep Syndrome" stimulates a variant as follows: My secretary, while driving home on the freeway in heavy traffic, was further disquieted when her 3-yearold son in the back of the station wagon suddenly bellowed and bounced. As she watched through her rearview mirror, he oscillated from behind the seat to partial view. She saw a snake-like object following his every move and obviously attached intimately to him. Working her way to the emergency stop lane, she crawled to the stationwagon storage area, bull-dogged the "dogie" and removed the batteryjumper clamp<i>cable</i>from her son's penis. The puncture wounds and hematoma healed uneventfully. Please add Jumper Cable Syndrome to the above.
Abstract 13988: Cardioprotective Effect of Beta-Blockers and ACE-Inhibitors in Breast Cancer Patients Treated with Trastuzumab: A Follow-Up Study of Heart Failure and Cardiac Function Over 12 Months
Authors: Thomas B Cook, Sinziana Seicean, Juan-Carlos Plana, Guilherme Oliveira, G. T Budd, Thomas Marwick
Journal: Circulation (2011)

Background: Cardiotoxicity is a potential complication of trastuzumab (TSZB) and anthracyclines in breast cancer therapy. We sought whether cardioprotection with Beta-Blockers (BB) and ACE-Inhibito...
INFORMATION INPUT OVERLOAD AND PSYCHOPATHOLOGY
Authors: JAMES G. MILLER
Journal: American Journal of Psychiatry (1960)

Although more than a thousand related articles were reviewed in our literature survey, no references were ever found in them or in their bibliographies crossing from one level, say the neurophysiology of the cell, to another, such as group psychology. In one article an offhand suggestion was found that such generalization might be possible, but it was apparent that in present-day behavioral science cross-level similarities are rarely considered and general systems properties seldom taken into account. This, despite the fact that at all levels comparable performance curves have been discovered. Since such general systems characteristics are not sought, the same phenomenon, with different names, different dimensions and units, is being discovered over and over again at different levels. Known for many years in neurophysiology, it is only recently being recognized at the individual level. Yet it is probable that, if information input overload causes similar performance curves and mobilization of comparable defenses at all levels of behaving systems, it can explain some of the psychopathology of everyday life and clinical practice.
Survival Trends for Patients With AIDS
Authors: George F. Lemp
Journal: JAMA (1990)

To evaluate trends in the length of survival for patients with acquired immunodeficiency syndrome, we calculated survival following diagnosis of acquired immunodeficiency syndrome for 4323 cases reported in San Francisco, Calif, between July 1981 and December 31, 1987. Patients were followed up prospectively through December 31, 1988. The median survival for all patients was 12.5 months, with a 5-year survival rate of 3.4%. Significantly improved survival was observed for patients diagnosed with<i>Pneumocystis carinii</i>pneumonia in 1986 and 1987. Survival for patients diagnosed with Kaposi's sarcoma declined significantly between 1981 and 1987. Survival was unchanged among patients diagnosed with other opportunistic infections or malignancies. Proportional hazards analyses indicated that initial diagnosis, age, and year of diagnosis were significant predictors of survival. For a subset of patients (n = 644), therapy with zidovudine was an additional significant predictor of survival. This study suggests that survival following diagnosis of acquired immunodeficiency syndrome has improved in recent years, primarily among patients with<i>carinii</i>pneumonia. Therapy with zidovudine may be partially responsible for these recent improvements. (<i>JAMA</i>. 1990;263:402-406)
Randomized controlled trial of sclerotherapy versus somatostatin infusion in the prevention of early rebleeding following acute variceal hemorrhage in patients with cirrhosis
Authors: Ángels Escorsell, Josep M Bordas, Luiz Ruiz del Arbol, José L Jaramillo, Ramon Planas, Rafael Bañares, Agustín Albillos, Jaume Bosch
Journal: Journal of Hepatology (1998)
comparison between DNA synthesis and mitosis in uninvolved and involved psoriatic epidermis and normal epidermis
Authors: PETER GOODWIN, SUSAN HAMILTON, LIONEL FRY
Journal: British Journal of Dermatology (1973)

Biopsies have been taken from the involved and uninvolved skin of eleven patients with psoriasis and the normal skin of six patients without psoriasis, 1 h after in vivo injection of 10 μCi of 3H-thymidine. Mitotic counts and counts of labelled cells (synesizing DNA) after autoradiography have been carried out. The ratio of mitoses to labelled cells was 1: 25 in clinical psoriasis, 1: 190 in uninvolved psoriatic epidermis and 1: 450 in normal epidermis. The number of labelled cells in clinical psoriasis was approximately 12 times greater than normal epidermis. However, the number of labelled cells in uninvolved psoriatic epidermis was approximately twice that of normal. These results imply an alteration in the components of the cell cycle in both involved and uninvolved psoriatic epidermis.
Cardiac troponin T mutations promote life-threatening arrhythmias
Authors: Céline Fiset, Wayne R. Giles
Journal: Journal of Clinical Investigation (2008)

Mutations in contractile proteins in heart muscle can cause anatomical changes that result in cardiac arrhythmias and sudden cardiac death. However, a conundrum has existed because mutations in one such contractile protein, a so-called Ca2+ sensor troponin T (TnT), can promote ventricular rhythm disturbances even in the absence of hypertrophy or fibrosis. Thus, these mutations must enhance abnormal electrophysiological events via alternative means. In this issue of the JCI, Baudenbacher et al. report a novel mechanism to explain this puzzle (see the related article beginning on page 3893). They show that a selected TnT mutation in the adult mouse heart can markedly increase the sensitivity of cardiac muscle myofilaments to Ca2+ and enhance the susceptibility to arrhythmia, even in the absence of anatomical deformities. As these same mutations can cause some forms of arrhythmias in humans, these findings are of both basic and translational significance.
Cut to the chase
Authors: D. Spence
Journal: BMJ (2009)

Television researchers are well spoken and “supportive,” but they are often exploitative too. From talent shows to daytime talk shows, vulnerable people are sucked into a Victorian freakshow, without even benefiting from the peep show penny. While channel flicking recently, I was struck by how many programmes there were on super-obese teens and their operations. The tone of the presenters remained passive and the comment minimal, for the voyeuristic spectacle said everything. But my inner voice was screaming, “So, who’s responsible for the fact that kids are becoming obese?” …
Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis.
Authors: R Kalluri, C F Shield, P Todd, B G Hudson, E G Neilson
Journal: Journal of Clinical Investigation (1997)

Normal glomerular capillaries filter plasma through a basement membrane (GBM) rich in alpha3(IV), alpha4(IV), and alpha5(IV) chains of type IV collagen. We now show that these latter isoforms are absent biochemically from the glomeruli in patients with X-linked Alport syndrome (XAS). Their GBM instead retain a fetal distribution of alpha1(IV) and alpha2(IV) isoforms because they fail to developmentally switch their alpha-chain use. The anomalous persistence of these fetal isoforms of type IV collagen in the GBM in XAS also confers an unexpected increase in susceptibility to proteolytic attack by collagenases and cathepsins. The incorporation of cysteine-rich alpha3(IV), alpha4(IV), and alpha5(IV) chains into specialized basement membranes like the GBM may have normally evolved to protectively enhance their resistance to proteolytic degradation at the site of glomerular filtration. The relative absence of these potentially protective collagen IV isoforms in GBM from XAS may explain the progressive basement membrane splitting and increased damage as these kidneys deteriorate.
RESPONSE TO D-TRP-6-LH-RH IN ADVANCED ADENOCARCINOMA OF PANCREAS
Authors: David Gonzalez-Barcena, NormaE. Rangel-Garcia, PatriciaL. Perez-Sanchez, Cesar Gutierrez-Damperio, Fausto Garcia-Carrasco, AnaMaria Comaru-Schally, AndrewV. Schally
Journal: The Lancet (1986)
LONG–TERM MORTALITY IN MINIMAL INVASIVE COMPARED TO STERNOTOMY CORONARY ARTERY BYPASS SURGERY IN GERIATRIC POPULATION (&gt; 75 YEAR–OLD PATIENTS).
Authors: Emad A. Barsoum, Basem Azab, Masood Shariff, Neeraj Shah, Joseph McGinn
Journal: Journal of the American College of Cardiology (2013)
Risk for Obstructive Sleep Apnea
Authors: David A. Nardone
Journal: Annals of Internal Medicine (2000)

Letters2 May 2000Risk for Obstructive Sleep ApneaDavid A. Nardone, MDDavid A. Nardone, MDVeterans Health Administration Medical Center; Portland, OR 97207 (Nardone)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-9-200005020-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I have been a primary care internist for more than 30 years, and I read with interest Netzer and colleagues' article (1) and Millman's editorial (2) on obstructive sleep apnea. Despite the recommendation that generalists take a sleep history using the Berlin Questionnaire, I remain skeptical. I reviewed the original data and recalculated the test measures. By using the gold standard—the respiratory disturbance index (RDI)—with a cutoff value greater than 5 indicating a positive result, 108 patients were at high risk and 9 were at low risk according to the Berlin Questionnaire (total, 117). Conversely, with an ...References1. Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131:485-91. LinkGoogle Scholar2. Millman RP. Do you ever take a sleep history? [Editorial]. Ann Intern Med. 1999;131:535-6. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Veterans Health Administration Medical Center; Portland, OR 97207 (Nardone) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUsing the Berlin Questionnaire To Identify Patients at Risk for the Sleep Apnea Syndrome Nikolaus C. Netzer , Riccardo A. Stoohs , Cordula M. Netzer , Kathryn Clark , and Kingman P. Strohl Do You Ever Take a Sleep History? Richard P. Millman Risk for Obstructive Sleep Apnea Ronald S. Strauss and Warren S. Browner Risk for Obstructive Sleep Apnea Nikolaus C. Netzer and Kingman P. Strohl Risk for Obstructive Sleep Apnea Frank Tamarin and Robert D. Brandstetter Metrics Cited byCardiovascular Complications in Obstructive Sleep Apnea SyndromeSleep Disordered Breathing in Renal Transplant PatientsSíndrome da apneia obstrutiva do sono em motoristas de caminhão 2 May 2000Volume 132, Issue 9Page: 758KeywordsHypertensionLikelihood ratioObesityOverweightQuestionnairesSleepSleep apnea Issue Published: 2 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Comparative in vitro bioactivity of cyclosporine on the proliferation of cultured peripheral blood mononuclear cells (PBMC) in sarcoidosis patients (SP) and healthy controls (HC)*1
Authors: P. Buddiga, R. Witkowska, A. Garcia, E. Capitle, J. Du, A. Mongia, L. Bielory
Journal: Journal of Allergy and Clinical Immunology (2004)
Endoscopic Therapy of Benign Tumors of the Papilla of Vater
Authors: Z. Zádorová, M. Dvoŕak, J. Hajer
Journal: Endoscopy (2001)

Background and Study Aims: The aim of this study was to evaluate the technical feasibility and safety of endoscopic treatment in 16 patients with benign adenomas of the papilla of Vater.
Fifth Disease: Still Hazy After All These Years
Authors: David M. Morens
Journal: JAMA (1982)

Ninety-three years ago, in 1889, Tschamer<sup>1</sup>described and defined "örtliche Rötheln," a curious childhood exanthem characterized by "slapped cheek" appearance with a lacy reticular rash of the extremities. Although it has been alleged that British dermatologist Robert Willan<sup>2</sup>observed the illness in the late 1700s as "rubeola sine catarrho," his description of the latter is unarguably of a different condition, as most probably is that of "roseola annulata."<sup>3</sup> In 1899 Sticker<sup>4</sup>named the illness—by then recognized in Western Europe—erythema infectiosum, and six years thereafter, Cheinisse<sup>5</sup>coined the term "fifth rash disease" (abbreviated "fifth disease") in deference to the four exanthematous diseases of childhood then acknowledged to be distinct on clinical and epidemiologic grounds: scarlet fever, rubeola, rubella, and epidemic pseudoscarlatina (Dukes' disease).<sup>6</sup>The intervening years have seen further clinical and epidemiologic clarification of fifth disease as a benign condition occurring sporadically in focal school
Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes
Authors: Mark A. Kay, Frank Graham, Frances Leland, Savio L. C. Woo
Journal: Hepatology (1995)

Alpha-1-antitrypsin is a relatively common genetic deficiency that results in early emphysema. The liver as the natural source of most alpha-1-antitrypsin synthesis was the target organ selected for gene replacement therapy studies. Previous work used recombinant retroviral vectors that encode the human alpha-1-antitrypsin cDNA for ex vivo and direct in vivo transduction of hepatocytes in dogs and rodents. This approach led to low levels of human protein in the serum of recipients. In this study, recombinant adenoviral vectors that express the human alpha-1-antitrypsin cDNA under the transcriptional control of the phosphoglycerate kinase (PGK) or RSV-LTR promoters have been constructed and used for the direct transduction of mouse hepatocytes in vivo. The animals transduced with the recombinant adenoviral vectors had therapeutic serum levels of human alpha-1-antitrypsin of up to 700 micrograms/mL. Thus, adenovirus-mediated gene transfer of the hAAT cDNA into the liver was able to produce therapeutic serum concentrations of protein.
712-5 Dynamic Left Ventricular Outflow Tract Obstruction Immediately Following Aortic Valve Replacement: Detection by Intra-operative Trans-esophageal Echocardiography
Authors: Dakshina R. Murthy, Chunguang Chen, Marc A. Paradis, Henry B. Low, Hiro Takata, Lee H. Ellison, Paul Preissler, Nancy Krupowies, Linda D. Gillam
Journal: Journal of the American College of Cardiology (1995)
Whatever Happened to Immunotoxins? Research, and Hope, Are Still Alive
Authors: D. C. Holzman
Journal: JNCI Journal of the National Cancer Institute (2009)

At the start of the 1980s, researchers began developing a new idea for cancer therapy. The logic was simple: Attach a toxin to an antibody that targets proteins present only on cancer cells. The early examples, chemically conjugated, are called immunotoxins, whereas the more advanced versions, genetically combined, are called fusion protein toxins. The first successful class member began development in the mid-1980s and gained U.S. Food and Drug Administration approval in 1999 for cutaneous T-cell lymphoma. Yet the fi eld is 30 years old and this drug, denileukin diftitox (Ontak), is still the only FDA-approved biologic in its class with just one more about to enter a phase III trial. Some researchers blame technological hurdles for the dearth of approved products. Others trace interruptions in research and development to the complex world of drug company mergers and intellectual property issues. Despite these obstacles, the fi eld has survived lean times and even seen a bit of a renaissance of late, according to experts who hope that recent advances will lead to fusion protein toxins aimed at a variety of solid tumors as well as leukemias. Many of the technical hurdles in devel
Oakum as a Surgical Dressing
Authors: R. Esler
Journal: BMJ (1884)

TI1EB BITI"I 7dDICtA JOUR1AL -651About six months ago the difficulty appeared to increase suddenly, so that it was only after great exertion that she could manage to get anything into her st.omach.; after she had taken food, it was vomited up in the course of texi minutes or so.All attempts to take solid food were given up some time ago, and, during the last three weekls, she could not even take the liquids, and had been fed entirely by means of nutrient enemata.On admission into the Westminster Hospital, the patient was greatly emaciated, with a sallow jaundiced skin.She complained of deep-seated pain in her chest and throat.There was increase of pain on deep pressure over the supra-sternal notch.No tumour could be felt in the neck, or any other part of the body.The heart-sounds are clear but weak ;-there was no dyspncea or alteration in the voice.The patient's lung-sounds are healthy; but, on deep inspiration, the breath-sounds were heard less clearly over the back of the right than over the left side.The abdomen appeared normal, the large intestine containing numerous hard lumps of faces, which disappeared after a large enema.An attempt was made to pass cesophageal bougies, but they were stopped at a point about twelve inches beyond the lips, and some bloody mucus was found attached to the end of the bougie when it was withdrawn.As the patient was rapidly failing, it was determined by Dr. H. Donkin and myself that gastrotomy should be performed as soon as possible.