tbuckley/cabot-search huggingface dataset:
Three simultaneous paraneoplastic manifestations (ichthyosis acquisita, Bazex syndrome, and Leser–Trélat sign) with prostate adenocarcinoma
Authors: Ana Cecília Michel da Rosa, Giselle Martins Pinto, Juliana Steckel Bortoluzzi, Rodrigo Pereira Duquia, Hiram Larangeira de Almeida
Journal: Journal of the American Academy of Dermatology (2009)
Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia
Authors: C Simioni, L M Neri, G Tabellini, F Ricci, D Bressanin, F Chiarini, C Evangelisti, A Cani, P L Tazzari, F Melchionda, P Pagliaro, A Pession, J A McCubrey, S Capitani, A M Martelli
Journal: Leukemia (2012)
THE IMPORTANCE OF A PROPER DIETARY FOLLOWING LAPAROTOMY.
Authors: C. W. WATTS
Journal: JAMA (1898)

We propose to divide the subject into three heads: the dietary preceding, the dietary at the time of, and the dietary following the operation. In order to be correctly understood we define a laparotomy to be any surgical operation performed upon the contents of the abdominal cavity at any point between the ensiform cartilage of the sternum and the symphisis pubis. And we propose to draw also the line of distinction between the operation performed on the organs contained therein and the other viscera, from the fact that the dietetics should be different from those necessary in cases of appendicitis, and operations performed upon the stomach and intestines. From an experience that covers a number of years, both in private and hospital practice, we are disposed to attribute the fatal results following operations on the abdominal cavity, more to the neglect of a proper dietary than to the direct result
Le transfert dans la cure pré-analytique
Authors: Charles Durand, Pedro Folch
Journal: Psychotherapy and Psychosomatics (1955)

Research Articles| January 20 2010 Le transfert dans la cure pré-analytique Subject Area: Psychiatry and Psychology Charles Durand; Charles Durand Prangins Search for other works by this author on: This Site PubMed Google Scholar Pedro Folch Pedro Folch Prangins Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1955) 3 (Suppl. 1): 73–80. https://doi.org/10.1159/000278635 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Charles Durand, Pedro Folch; Le transfert dans la cure pré-analytique. Acta Psychotherapeutica et Psychosomatica 1 January 1955; 3 (Suppl. 1): 73–80. https://doi.org/10.1159/000278635 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1955Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Asthma drug delivery devices for children
Authors: C. O'Callaghan
Journal: BMJ (2000)

Aging incurs aortic stiffening and dilation, but these changes are less pronounced in peripheral arteries, resulting in stiffness and geometry gradients influencing progression of the forward and reflected pressure waves. Because premature arterial aging is observed in ESRD, we determined the respective roles of stiffness and aortic geometry gradients in 73 controls and 156 patients on hemodialysis. We measured aortic pulse wave velocity (PWV) and brachial PWV to evaluate the stiffness gradient [(brachial PWV/aortic PWV)<sup>0.5</sup>] and ascending aortic and aortic bifurcation diameters to assess aortic taper (ascending aortic diameter/aortic bifurcation diameter). The global reflection coefficient was estimated from characteristic impedance and vascular resistance. Cox proportional hazard models were used to determine mortality risk. The age-associated increase in aortic PWV was higher in patients (<i>P</i>&lt;0.001). In controls, aortic ascending and bifurcation diameters increased with age, with an unchanged aortic taper. In patients on hemodialysis, age did not associate with increased ascending aortic diameter but did associate with increased aortic bifurcation diameter and decreased aortic taper, both of which also associated with abdominal aortic calcifications and smaller global reflection coefficient (<i>P</i>&lt;0.001). In patients, multivariate models revealed all-cause and cardiovascular mortality associated with age, aortic PWV, and aortic bifurcation diameter with high specificity and sensitivity. Using stiffness gradient, aortic taper, or global reflection coefficient in the model produced similar results. Thus, whereas aortic stiffness is a known independent predictor of mortality, these results indicate the importance of also evaluating the aortic geometry in patients on hemodialysis.
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Authors: Laura K Mackay, Azad Rahimpour, Joel Z Ma, Nicholas Collins, Angus T Stock, Ming-Li Hafon, Javier Vega-Ramos, Pilar Lauzurica, Scott N Mueller, Tijana Stefanovic, David C Tscharke, William R Heath, Michael Inouye, Francis R Carbone, Thomas Gebhardt
Journal: Nature Immunology (2013)
Dr Wendy Orr and the Health of Detainees in South Africa
Authors: F. P. Retief
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The contribution by Nightingale and Stover in your May 23/30, 1986, issue entitled "A Question of Conscience,"<sup>1</sup>dealing with Dr Wendy Orr, Steve Biko, and a report published by two researchers at the University of Cape Town's Institute of Criminology, demands my comment. The circumstances surrounding Dr Orr's successful application to the Eastern Cape Presiding Judge to restrain the Minister of Police and his officers from assaulting present and future detainees are as follows: Dr Orr was at the time working in the office of the Port Elizabeth District Surgeon examining detainees, among other duties. She concluded from evidence presented to her that detainees were being systematically assaulted. The police denied these allegations and a total of 164 replying affidavits were submitted to the Supreme Court. Before the case was heard, Dr Orr and her coapplicants withdrew their application on the grounds that it had become
Bleeding tendency, platelet function, and pharmacokinetics of ibuprofen and zidovudine in HIV(+) hemophilic men
Authors: Margaret V. Ragni, Barbara J. Miller, Robert Whalen, Richard Ptachcinski
Journal: American Journal of Hematology (1992)

The use of ibuprofen (IBP) in hemophilic men for chronic hemophilic arthropathy is associated with transient coagulation abnormalities, but usually does not cause bleeding symptoms. However, when hemophilic men are treated with ibuprofen while also receiving zidovudine (ZDV), excess bleeding has occurred in some. In order to evaluate platelet function and pharmacokinetics of combination IBP and ZDV, we measured platelet aggregation, platelet adhesive index, bleeding time, and IBP and ZDV drug levels by high performance liquid chromatography on five patients receiving chronic oral IBP, 400 mg every 6 hr, and on ten patients receiving both IBP and ZDV, 100 or 200 mg every 4 hr five times daily. Samples were obtained at baseline (ZDV alone), acutely (IBP+ZDV acutely), and chronically (2 weeks on IBP and ZDV). Abnormal platelet aggregation with arachidonic acid occurred in four of five (80%) of those receiving IBP alone and in 7 of 10 (70%) at baseline, 9 of 10 (90%) at acute, and 8 of 10 (80%) at chronic IBP and ZDV treatment, most commonly at 2 hr following dosing, when peak IBP levels occurred, and persisting 4 hr in those on chronic dosing. Half or more of those on combination IBP+ZDV showed a lowered platelet adhesive index and/or prolonged bleeding time. Excess bleeding symptoms occurred in three on chronic combination IBP+ZDV, two with increased frequency of spontaneous hemorrhages, and one with prolonged traumatic bleeding. Bleeding tendency was unrelated to the degree of platelet function abnormality, to peak drug levels of IBP or ZDV, or degree of liver function abnormality (SGPT). The clearance of IBP alone and ZDV alone were not different from the clearance of combination IBP and ZDV. Caution is urged regarding potential enhanced bleeding tendency in hemophiliacs receiving both IBP and ZDV in combination.
A Comprehensive Framework for Human Resources for Health System Development in Fragile and Post-Conflict States
Authors: Noriko Fujita, Anthony B. Zwi, Mari Nagai, Hidechika Akashi
Journal: PLoS Medicine (2011)

Noriko Fujita and colleagues offer a comprehensive framework for human resource system development, based upon experiences in three fragile and post-conflict health systems: Afghanistan, the Democratic Republic of Congo, and Cambodia.
Surgical treatment of post-cricoid carcinoma
Authors: K. Mullard
Journal: Thorax (1968)

Experience of the treatment of 20 patients with post-cricoid carcinoma is reported, and the conclusion reached was that radical surgery is the best form of treatment, using radiotherapy to deal with subsequent developments. The surgical procedure used has been a single-stage pharyngolaryngectomy and total oesophagectomy with restoration of continuity by a posterior mediastinal colon transplant.
Epidemic Visceral Leishmaniasis in Southern Sudan: Treatment of Severely Debilitated Patients under Wartime Conditions and with Limited Resources
Authors: Jill Seaman
Journal: Annals of Internal Medicine (1996)

Objectives: 1] To determine the proportions of patients with visceral leishmaniasis who had various treatment outcomes when cared for under wartime conditions and with limited resources and 2) to identify patient characteristics associated with the outcomes. Design: Cohort study. Setting: Medicins sans Frontieres-Holland's treatment center in Duar, Western Upper Nile province, an area in southern Sudan that has been severely affected by Sudan's civil war and a massive epidemic of visceral leishmaniasis. Patients: 3076 consecutive patients who had visceral leishmaniasis, were admitted to the treatment center the first year the center was operational (August 1990 to July 1991), and were treated with the pentavalent antimonial compound sodium stibogluconate. Measurements: Patient characteristics on admission and four mutually exclusive treatment outcomes (default during first admission, death during first admission, discharge and readmission for retreatment [relapse], and discharge and no readmission for retreatment [successful treatment]). Results: The patients had a median age of 15 years and were notably anemic (median hemoglobin level, 77 g/L) and malnourished (median body mass index of adults [more than equals 18 years of age], 15.2 kg/m2); most (91.0%) had been sick less than 5 months. Although patients could not be monitored after treatment to document cure, most (2562 [83.3%]) were successfully treated; 336 (10.9%) died during their first admission, and 79 are known to have relapsed (3.0% of those discharged alive [that is, those whose final treatment outcome was successful treatment or relapse]). In univariable analysis, young and older age (< 5 or more than equals 45 years of age), long duration of illness (≥ 5 months), markedly low hemoglobin level or body mass index, large spleen, high parasite density, and vomiting at least once during the treatment course were associated with death. In multiple logistic regression analysis of data for a subgroup of 1207 adults (those who did not default or relapse and for whom data were recorded on age, sex, duration of illness, hemoglobin level, body mass index, and spleen size), the approximate risk ratios for death were 2.2 (95% CI, 1.4 to 3.6) for those with a long duration of illness, 3.6 (CI, 2.1 to 5.9) for those 45 years of age or older, 4.6 (CI, 2.2 to 9.4) for those with a hemoglobin level less than 60 g/L, and 12.2 (CI, 3.2 to 47.2) for those with a body mass index less than 12 kg/m2. Conclusion: Despite the severe debility of the patients and the exceptionally difficult circumstances under which they were treated, most fared remarkably well.
Factors associated with the relapse of infantile haemangiomas in children treated with oral propranolol
Authors: C.K. Ahogo, K. Ezzedine, S. Prey, V. Colona, A. Diallo, F. Boralevi, A. Taïeb, C. Léauté-Labrèze
Journal: British Journal of Dermatology (2013)

Although propranolol has become the first-line therapy for infantile haemangiomas (IHs), no study has yet investigated factors associated with the risk of relapse in children with IH treated with propranolol after cessation of treatment.To compare factors associated with the risk of relapse in children with IH treated with oral propranolol.We conducted a single-centre retrospective observational study. All files and photographs of patients with IH aged 5 months or less at the time of treatment initiation, and who were seen between 1 June 2008 and 31 December 2011 at the National Reference Center for rare skin diseases of Bordeaux, were retrospectively reviewed.In total 158 children were included, of whom 118 had not relapsed and 40 had relapsed. Fifty-two patients were boys and 106 were girls (male : female ratio 1 : 2), and 19 had a segmental IH (12%). When conducting multivariate analysis, only IHs with a deep component and those with segmental distribution were independently associated with relapse.Our study shows that segmental IHs, as well as haemangiomas with a deeper component, are more at risk of relapse and should thus indicate closer follow-up after treatment interruption, and/or longer treatment.
Self-Administration of Allergy Desensitization Extracts-Reply
Authors: Frederic Speer
Journal: JAMA (1977)

Allowing patients to inject maintenance doses of allergens involves some risk. But such risk is by no means limited to allergens. Drs Grossman and Ball do well to cite the example of insulin. Suddenly and without warning an insulin injection may cause anaphylactic Shock 1 or hypoglycemic shock.  But injection is not the only hazard of self-administration. Every prescription for oral penicillin for home use carries with it the possibility of a dangerous reaction. 2 And nobody knows better than the allergist that penicillin is only one of many drugs that may cause serious reactions when given by mouth.  Ideally, of course, injections of any kind are best given in a physician's office or similar facility. In the geographic area we serve, the patient may live far from a physician's office. As an extreme example, one of our patients lives in a county in the High Plains that
Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes
Authors: Nathan D Chamberlain, Seung-jae Kim, Olga M Vila, Michael V Volin, Suncica Volkov, Richard M Pope, Shiva Arami, Arthur M Mandelin, Shiva Shahrara
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Objective</h3> The aim of the study was to characterise the expression, regulation and pathogenic role of toll-like receptor 7 (TLR7) and TLR8 in rheumatoid arthritis (RA). <h3>Methods</h3> Expression of TLR7 and TLR8 was demonstrated in RA, osteoarthritis (OA) and normal (NL) synovial tissues (STs) employing immunohistochemistry. The authors next examined the mechanism by which TLR7 and TLR8 ligation mediates proinflammatory response by Western blot analysis and ELISA. Expression of TLR7 and TLR8 in RA monocytes was correlated to disease activity score (DAS28) and tumour necrosis factor α (TNFα) levels. Further, the effect of TLR7 ligation in RA monocytes was determined on synovial fluid (SF)-mediated TNFα transcription. <h3>Results</h3> TLR7/8 are predominately expressed in RA ST lining and sublining macrophages. The authors show that NF-κB and/or PI3K pathways are essential for TLR7/8 induction of proinflammatory factors in RA peripheral blood (PB)-differentiated macrophages. Expression of TLR7 in RA monocytes shows a strong correlation with DAS28 and TNFα levels. By contrast, expression of TLR8 in these cells does not correlate with DAS28, TLR7 or TNFα levels. The authors further demonstrate that RNA from RA SF, but not RA or NL plasma, could modulate TNFα transcription from RA monocytes that can be downregulated by antagonising TLR7 ligation or degradation of single stand (ss) RNA. Thus, ssRNA present in RA SF may function as a potential endogenous ligand for TLR7. <h3>Conclusions</h3> These results suggest that expression of TLR7, but not TLR8, may be a predictor for RA disease activity and anti-TNFα responsiveness, and targeting TLR7 may suppress chronic progression of RA.
Bronchoalveolar lavage in adult sickle cell patients with acute chest syndrome: value for diagnostic assessment of fat embolism.
Authors: B Godeau, A Schaeffer, D Bachir, J Fleury-Feith, F Galacteros, F Verra, E Escudier, J N Vaillant, C Brun-Buisson, A Rahmouni, A S Allaoui, F Lebargy
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Fat embolism of necrotic bone marrow could be a frequent cause of acute chest syndrome (ACS) in sickle cell syndromes (SC), as suggested by postmortem findings. To check this hypothesis in living patients, we evaluated the presence of fatty macrophages recovered by bronchoalveolar lavage (BAL) in ACS. We investigated 20 consecutive cases of ACS by BAL, and identification of alveolar cells containing fat droplets was performed using oil red O (ORO), a specific neutral fat stain. The specificity of the method was determined on control groups, including eight SC patients without acute chest syndrome and 15 non-SC patients. A cut-off of > 5% of alveolar macrophages containing fat droplets was determined from the control groups to assess the diagnosis of fat embolism. In 12 ACS episodes, BAL exhibited > 5% of fatty macrophages, ranging from 10% to 100% (median value 46.5%). In 11 cases, fat embolism was associated with proven (n = 8) or probable (n = 3) bone marrow infraction, which mostly predated ACS. Eight ACS episodes were associated with a low percentage (< or = 5%) of fatty alveolar macrophages and could be related to a cause other than fat embolism in six episodes, such as sepsis, in-situ thrombosis, or rib infarcts generating hypoventilation. This study supports the diagnostic yield of BAL for fat embolism, which can be incriminated in 60% of cases of ACS in this adult population.
Carcinoma of Breast and Tubercular Abscess.
Authors: Lewis E. Maker
Journal: JAMA (1898)

Sac City, Iowa, Dec. 20, 1898. <h3>To the Editor:</h3> —The apparently increasing tendency of tubercular abscess and carcinoma of the mammary region leads the writer to briefly recite the history of a case on whom he operated for such affections: Mrs. S., white, 30 years of age, called at my office for treatment for rheumatism, complaining of intense pain in the chest. She had constant dread of cancer of the breast. On the right breast, just below the nipple, a growth was noticed, about the size of a walnut. The other breast was normal. There was enlargement of ankle-joint, pain in the fingers, but the glands did not seem to be enlarged. There was discoloration of the right nipple, which was somewhat retracted. There was a history of tuberculosis on the father's side, and one aunt and sister had been operated on for cancer. Her urine was acid in reaction;
Adjuvants to L-dopa for Parkinsonism.
Authors: J Braham
Journal: BMJ (1970)

Adjuvants to L-dopa for Parkinsonism SIR,-Notwithstanding the generally satisfactory response of Parkinsonian patients to L-dopa, undesirable side-effects and the high cost of the drug have led to attempts to reduce dosage with the aid of other agents.Success in this field has been reported using dopa-decarboxylase inhibitors,'
Association of Coronary Heart Disease Risk Factors With Microscopic Qualities of Coronary Atherosclerosis in Youth
Authors: Henry C. McGill, C. Alex McMahan, Arthur W. Zieske, Richard E. Tracy, Gray T. Malcom, Edward E. Herderick, Jack P. Strong
Journal: Circulation (2000)

Background —This study examined whether atherosclerosis in young people is associated with the risk factors for clinical coronary heart disease (CHD). Methods and Results —Histological sections of left anterior descending coronary arteries (LADs) from 760 autopsied 15- to 34-year-old victims of accidents, homicides, and suicides were graded according to the American Heart Association (AHA) system and computerized morphometry. Risk factors (dyslipoproteinemia, smoking, hypertension, obesity, impaired glucose tolerance) were assessed by postmortem measurements. Approximately 2% of 15- to 19-year-old men and 20% of 30- to 34-year-old men had AHA grade 4 or 5 (advanced) lesions. No 15- to 19-year-old women had grade 4 or 5 lesions; 8% of 30- to 34-year-old women had such lesions. Approximately 19% of 30- to 34-year-old men and 8% of 30- to 34-year-old women had atherosclerotic stenosis ≥40% in the LAD. AHA grade 2 or 3 lesions (fatty streaks), grade 4 or 5 lesions, and stenosis ≥40% were associated with non-HDL cholesterol ≥4.14 mmol/L (160 mg/dL). AHA grade 2 or 3 lesions were associated with HDL cholesterol &lt;0.91 mmol/L (35 mg/dL) and smoking. AHA grade 4 or 5 lesions were associated with obesity (body mass index ≥30 kg/m 2 ) and hypertension (mean arterial pressure ≥110 mm Hg). Conclusions —Young Americans have a high prevalence of advanced atherosclerotic coronary artery plaques with qualities indicating vulnerability to rupture. Early atherosclerosis is influenced by the risk factors for clinical CHD. Long-range prevention of CHD must begin in adolescence or young adulthood.