Antiplatelet Treatment of Thrombotic Thrombocytopenic Purpura
Authors: EDWARD L. AMOROSI
Journal: Annals of Internal Medicine (1977)

Editorials1 January 1977Antiplatelet Treatment of Thrombotic Thrombocytopenic PurpuraEDWARD L. AMOROSI, M.D., SIMON KARPATKIN, M.D.EDWARD L. AMOROSI, M.D.Search for more papers by this author, SIMON KARPATKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-102 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the 50 years since its first description (1), some aspects of the pathogenesis of thrombotic thrombocytopenic purpura have been clarified, but its etiologic definition and the development of effective therapy have remained elusive tasks. Instances of its occurrence in siblings (2) or marital partners (3) and its response in one case to hemodialysis (4) have suggested an environmental causative agent(s) (viral, bacterial, antigenic, or toxic) interacting with a genetically predisposed host. Various therapeutic regimens have been applied including adrenocorticosteriods and splenectomy (5, 6), heparin (7), exchange transfusion (8), and antiplatelet agents (9-23) (aspirin, dipyridamole, sulfinpyrazone, and dextran), but definitive...References1. MOSCHCOWITZ E: An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries. An undescribed disease. Arch Intern Med 36:89-93, 1925 CrossrefGoogle Scholar2. WALLACELOVRICCLUBB DAJ: Thrombotic thrombocytopenic purpura in four siblings. Am J Med 58:724-734, 1975 CrossrefMedlineGoogle Scholar3. WATSONCOOPER CW: Thrombotic thrombocytopenic purpura. Concomitant occurrence in husband and wife. JAMA 215:1821-1822, 1971 CrossrefMedlineGoogle Scholar4. TARTAGLIABURKART AP: Thrombotic thrombocytopenic purpura. Remission following hemodialysis. JAMA 218:999-1001, 1971 CrossrefMedlineGoogle Scholar5. 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