tbuckley/cabot-search huggingface dataset:
Discrepancies Between Iodine and Technetium Thyroid Scintigraphy
Authors: Jack D. Barth
Journal: JAMA (1978)

FOR ROUTINE thyroid scanning, the sodium pertechnetate Tc 99m scan is preferred over sodium iodide I 131 scanning in many laboratories. Radiation safety for the patient and reduction of costs are the primary reasons for this.  Discrepancies can occur between iodine scans (iodine I 123 and131I) as compared with99mTc scans: eg, a nodule appearing cold on an iodine scan may be warm with a99mTc scan.1-3To give other examples of discrepancies that can occur when99mTc is compared with iodine, we present two cases.  Report of Cases  Case 1.—  A 69-year-old woman was admitted to the hospital for regulation of her diabetes mellitus. She had been insulin-dependent for the past 20 years. At the physical examination, a nodule that was 3 cm in diameter was palpable in the lower part of the right lobe of the thyroid. The nodule was not connected
Abstract 713: Active hedgehog pathway in human primary gastric tumor models
Authors: Shijun Yu, Chao Wu, Xiaoming Song, Taiping Chen, Jean-Pierre Wery, Yiyou Chen
Journal: Cancer Research (2010)

Abstract The hedgehog (Hh) signaling pathway is known to be essential for multiple aspects of embryonic development, and activation of the Hh pathway leads to the development of several human malignancies such as basal cell carcinoma and medulloblastoma. Recent data have implicated a much broader role of the Hh pathway in other human cancer as well as the maintenance of cancer stem cells. Loss-function mutation of Ptc and gain of gunction mutation of Smo in human malignancies make the components in Hh pathway attractive therapeutic targets. However, this pathway is readily deactivated once human tumor cells are propagated in cell culture, a prerequisite of most preclinical human cancer models. In order to identify useful models for the evaluation of novel therapeutics targeting the Hh pathway, we profiled the expression of Ptc, Smo, Gli in a cohort of twenty established human primary gastric tumor models by TaqMan real-time quantitative PCR reaction and immunohistochemistry (IHC). Seven of the twenty models displayed high expression of either Gli-1 or Gli-2. Eight models were found to have high expression level of Shh. And three models were found to have high level of Ptc. The Gli protein expression level is also examined with IHC. High levels of Gli and Shh in the selected models will be very useful to evaluate anticancer drugs against Hh signaling pathway for their drug activity and pharmacodynamic responses. These models, together with the associated clinical and pathological information, provide a unique platform to evaluate the in vivo activities of pharmaceutical agents targeting the Hh pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 713.
Prognostic Significance of FDG PET/CT on the Follow-up of Patients of Differentiated Thyroid Carcinoma With Negative I131 Whole-Body Scan and Elevated Thyroglobulin Levels
Authors: Federico Caobelli, Claudio Pizzocaro, Ugo Paolo Guerra
Journal: Clinical Nuclear Medicine (2013)

Department of Nuclear Medicine Department Fondazione Poliambulanza Brescia, Italy [email protected] Conflicts of interest and sources of funding: none declared.
Second symposium on the definition and management of anaphylaxis: Summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
Authors: Hugh A. Sampson, Anne Muñoz-Furlong, Ronna L. Campbell, N. Franklin Adkinson, S. Allan Bock, Amy Branum, Simon G.A. Brown, Carlos A. Camargo, Rita Cydulka, Stephen J. Galli, Jane Gidudu, Rebecca S. Gruchalla, Allen D. Harlor, David L. Hepner, Lawrence M. Lewis, Phillip L. Lieberman, Dean D. Metcalfe, Robert O'Connor, Antonella Muraro, Amanda Rudman, Cara Schmitt, Debra Scherrer, F. Estelle R. Simons, Stephen Thomas, Joseph P. Wood, Wyatt W. Decker
Journal: Journal of Allergy and Clinical Immunology (2006)
The nursing profession's coming of age: A difference in cultures
Authors: Ayan S Panja
Journal: BMJ (2006)

The nursing profession's coming of age The end of medicine as a professionEditor-Young describes the coming of age of the nursing profession. 1 All professions and occupations are human creations and therefore are subject to change.With the widening of roles of many professions, it becomes harder to define what a doctor can do that can't be done by an appropriately trained member of another profession.Perhaps major surgery and certifying cause of death are all that remains.With the increasing difficulty of getting junior doctors to do anything that may be regarded as work (rather than education) we doctors may be engineering the abolition of our profession, and we may move from distinct professions to practitioners from varied backgrounds being trained for a particular function.
Blood pressure in sleep.
Authors: A. W. Raffan
Journal: BMJ (1968)

Tricyclic Antidepressants SIR,-I am worried by one sentence in the article on tricyclic antidepressants (13 April, p. 102): "Jaundice, which is very un- common, is of the cholestatic type similar to that found in chlorpromazine."This is mis- leading.Jaundice is one of the more frequent side- effects reported from imipramine and imitrip- tyline, the most widely used members of the group.Its incidence is probably related to the amount of drug prescribed, and is only likely to be "very uncommon" with the newer compounds.I doubt, too, if the jaundice is always of the chlorpromazine type; this implies a cholestatic reaction which is usually benign.Some patients almost cer- tainly have a far more serious hepatic reac- tion, and death can result from liver-cell failure.-I am, etc.,
Self-poisoning with barbiturates in England and Wales during 1959-74.
Authors: M W Johns
Journal: BMJ (1977)

Hospital admissions due to acute barbiturate poisoning per million population in England and Wales have decreased since 1965 at about the same rate as NHS prescriptions for barbiturates. Admissions due to poisoning with other drugs have increased, but, largely because the benzodiazepine hypnotics and tranquillisers are much less toxic than the barbiturates that they are replacing, deaths from poisoning with all solids and liquids have decreased. The risk of death from self-poisoning associated with each barbiturate prescription has increased two and a half times since 1961, perhaps partly because greater quantities of barbiturate are being dispensed with each prescription and partly because patients for whom these drugs are still being prescribed would, in the event of an overdose, be unlikely to be found and admitted to hospital in time owing to their age and social circumstances. There is now little to justify prescribing barbiturate hypnotics or sedatives for anyone.
Relation between duodenal ulcer and blood group in people of the Udaipur region of India.
Authors: D C Sharma, R C Jain, S S Dave
Journal: Gut (1969)

only two normal.All my cases were normal.It goes without saying that the response of stomachs of duodenal ulcer patients to stimuli of acid and pepsin secretion cannot be considered normal.Similar hyperparathyroid patients cannot be considered normal in two respects: the continuous increased parathyroid hormone which was proved, in my department and elsewhere, to be a stimulus to gastric acidity, and the prolonged hyper- calcaemia present.3 The accordance of my results with animal experi- ments, carried on canine animals, is, I believe, ascribed to the attainment of nearly equal blood levels of calcium in my cases to those reported in animal experiments.Thus to my mind, in the two normal cases of Dr Smallwood, excluding all the duodenal ulcer and hyper- parathyroid not being comparable to my cases, the results he obtained differ from my results and animal results due to the small dose of calcium given to these patients, 630 and 945 mg in cases 3 and 1 respectively.
Family Tension in the Search for a Kidney Donor
Authors: Roberta G. Simmons
Journal: JAMA (1971)

The search for a kidney transplant donor is a significant decision-making stress for many extended families. The family is asked to donate the kidney of one member to save the life of another. Seventy-nine cases were reviewed and family tension is noted in 21 of these. It is concluded that earlier studies have minimized the nature of this crisis, because they have not focused on the family as an interacting unit or on the nondonor—the family member who "could" donate but does not.
476 LIVER STIFFNESS MEASUREMENT ASSESSED BY FIBROSCAN PREDICTS RESPONSE TO ANTI-VIRAL TREATMENT IN PATIENTS WITH GENOTYPE 2 AND 3 CHRONIC HEPATITIS C
Authors: L. Christian, A. Nkhoma, A. Price, M. Schmid, C. Miller, K. Baxter, M. Bassendine, S. McPherson
Journal: Journal of Hepatology (2013)
Harold Bernard Watson
Authors: R D S Watson
Journal: BMJ (2005)

Former consultant obstetrician and gynaecologist Solihull and East Birmingham hospitals and honorary senior clinical lecturer University of Birmingham (b Birmingham 1917; q Birmingham 1940; FRCS, FRCOG), died from Parkinson's disease on 28 December 2004.

Harold Watson was posted to Solihull in 1941, where he worked in both general surgery and then obstetrics and gynaecology for more than 50 years. He worked to develop the facilities at Solihull Hospital and was delighted when a new obstetric unit opened in 1972, where he delivered his first grandson, the unit's first Christmas baby. After retirement he continued in practice and established a successful fertility programme based at Solihull Parkway Hospital. Predeceased by his first wife, Barbara, he leaves his second wife, Joan, and three children.
Functional Effect of the C242T Polymorphism in the NAD(P)H Oxidase p22phox Gene on Vascular Superoxide Production in Atherosclerosis
Authors: Tomasz J. Guzik, Nick E. J. West, Edward Black, Denise McDonald, Chandi Ratnatunga, Ravi Pillai, Keith M. Channon
Journal: Circulation (2000)

Background —Increased superoxide anion production increases oxidative stress and reduces nitric oxide bioactivity in vascular disease states. NAD(P)H oxidase is an important source of superoxide in human blood vessels, and some studies suggest a possible association between polymorphisms in the NAD(P)H oxidase CYBA gene and atherosclerosis; however, no functional data address this hypothesis. We examined the relationships between the CYBA C242T polymorphism and direct measurements of superoxide production in human blood vessels. Methods and Results —Vascular NAD(P)H oxidase activity was determined in human saphenous veins obtained from 110 patients with coronary artery disease and identified risk factors. Immunoblotting, reverse-transcription polymerase chain reaction, and DNA sequencing showed that p22phox protein, mRNA, and 242C/T allelic variants are expressed in human blood vessels. Vascular superoxide production, both basal and NADH-stimulated, was highly variable between patients, but the presence of the CYBA 242T allele was associated with significantly reduced vascular NAD(P)H oxidase activity, independent of other clinical risk factors for atherosclerosis. Conclusions —Association of the CYBA 242T allele with reduced NAD(P)H oxidase activity in human blood vessels suggests that genetic variation in NAD(P)H oxidase components may play a significant role in modulating superoxide production in human atherosclerosis.
FURTHER EXPERIENCE WITH THE VERTICAL OVERLAPPING OPERATION FOR THE RADICAL CURE OF UMBILICAL HERNIA.
Authors: WILLIAM J. MAYO
Journal: JAMA (1903)

The results of operations for the radical cure of umbilical herniæin adults have; heretofore, not been encouraging. These patients are usually obese, with attenuated abdominal muscles, and the thin, rigid character of the ring does not offer mechanical conditions advantageous to lasting union. The principles of closure have been the same as after an ordinary abdominal section, the object being to split the fascia at the ring margins laterally, until the recti muscles are reached, and then, by a series of buried sutures, to reconstruct the abdominal wall in layers. The defect in this method is the natural separation of the recti muscles at the level of the umbilicus. Below this point the muscular structures are practically in contact, but above there is from one-fourth to three-fourths of an inch separation. To bring the recti together in this locality amounts to a muscle transplantation. In a small hernia this muscular
Changes in Physicians' Attitudes Toward Telling the Cancer Patient
Authors: Dennis H. Novack
Journal: JAMA (1979)

In answer to a questionnaire administered in 1961, 90% of responding physicians indicated a preference for not telling a cancer patient his diagnosis. To assess attitudinal changes, the same questionnaire was submitted to 699 university-hospital medical staff. Of 264 respondents, 97% indicated a preference for telling a cancer patient his diagnosis—a complete reversal of attitude. As in 1961, clinical experience was the major policy determinant, but the 1977 population emphasized the influence of medical school and hospital training. Our respondents indicated less likelihood that they would change their present policy or be swayed by research. Clinical experience was the determining factor in shaping two opposite policies. Physicians are still basing their policies on emotion-laden personal conviction rather than the outcome of properly designed scientific studies. (<i>JAMA</i>241:897-900, 1979)
Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine
Authors: Mihai Gheorghiade, Ferenc Follath, Piotr Ponikowski, Jeffrey H. Barsuk, John E.A. Blair, John G. Cleland, Kenneth Dickstein, Mark H. Drazner, Gregg C. Fonarow, Tiny Jaarsma, Guillaume Jondeau, Jose Lopez Sendon, Alexander Mebazaa, Marco Metra, Markku Nieminen, Peter S. Pang, Petar Seferovic, Lynne W. Stevenson, Dirk J. van Veldhuisen, Faiez Zannad, Stefan D. Anker, Andrew Rhodes, John J.V. McMurray, Gerasimos Filippatos
Journal: European Journal of Heart Failure (2010)
Disease and Social Diversity: The European Impact on the Health of Non-Europeans
Authors: Anthony J. Martel
Journal: JAMA (1995)

The title, along with the clear statement in the preface of the writer's personal experience, will of necessity limit reading of this book for the practicing physician. The study of native peoples in Polynesia, Australia, and North America reflects the interesting and unique experience of Dr Kunitz. A message is most certainly to be found in this attempt at an integrated work on how diversity contributes significantly to disease patterns in human beings. Through observations and reflections following upon direct experiences in diverse areas of the world, the author formulates innovative concepts to explain mortality and morbidity among various indigenous peoples. The author's views, as he states, differ greatly from standard theories on the impact of contact between Europeans and non-Europeans in the Americas and Oceania.  The book is logically and clearly written, backed with an extensive bibliography and supportive appendix and charts. I believe the subject matter and the
Is Good Nursing-Home Care Feasible?
Authors: Robert L. Kane, Ann Jorgensen, Barbara Teteberg, Jean Kuwahara
Journal: JAMA (1976)

A program using a team consisting of a nurse practitioner and a social worker to provide care for nursing-home patients was established. An important feature is the use of a specially designed problem-oriented record. The project disclosed a number of current deficiencies in nursing-home care and demonstrated ways to remedy many of these. The overall cost of the project was offset by the savings realized from reduced hospitalization and related medical costs. (<i>JAMA</i>235:516-519, 1976)
Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence
Authors: Hanna Bloomfield Rubins
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes4 July 2000Cholesterol-Lowering Therapy: Evaluation of Clinical Trial EvidenceHanna Bloomfield Rubins, MD, MPHHanna Bloomfield Rubins, MD, MPHCenter for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota. (Bloomfield)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Grundy SM, ed. 352 pages. New York: Marcel Dekker; 2000. $150.00. ISBN 082478216X. Order phone 800-228-1160.Field of medicine: Endocrinology, cardiology, and prevention.Format: Hardcover book.Audience: Internists, endocrinologists, cardiologists, and providers interested in the clinical trial evidence underlying management of hypercholesterolemia.Purpose: To “bring together in one place” the rationale for and results of trials of the second-generation lipid-lowering therapies.Content: The bulk of the book comprises in-depth discussions of the design, rationale, and results of the major clinical end points trials of statin therapy for primary and secondary prevention of coronary disease. Overviews of smaller trials using coronary ... Author, Article, and Disclosure InformationAffiliations: Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota. (Bloomfield) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 July 2000Volume 133, Issue 1Page: 80KeywordsAtheromasAtherosclerosisClinical trialsEndocrinologyLipid disordersSoftware toolsStatins ePublished: 15 August 2000 Issue Published: 4 July 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Anti-HCV seroprevalence in pregnant women in France.
Authors: F Roudot-Thoraval, J M Pawlotsky, L Deforges, P P Girollet, D Dhumeaux
Journal: Gut (1993)

In a study designed to assess the prevalence of antibodies to hepatitis C virus (HCV) in pregnant women, anti-HCV positivity in French pregnant women was twice as high as that found in French blood donors. Positive ELISA 2 results were confirmed by positive RIBA 2 in most subjects, and seven of nine RIBA 2 positive patients also tested positive for HCV-RNA by PCR. High rates of anti-HCV positivity were seen among immigrant pregnant women, partly because of false positive results with ELISA 2. RIBA 2 results suggested that the prevalence of HCV infection was not any higher in immigrant compared with French pregnant women.
Beyond the Good Death: The Anthropology of Modern Dying
Authors: Michael B. Bevins
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Self-Expanding Metal Stents for Palliation of Malignant Gastric Outlet Obstruction
Authors: S. Truong, V. Bohndorf, H. Geller, V. Schumpèlick, R. W. Günther
Journal: Endoscopy (1992)

Treatment of inoperable gastric outlet obstruction caused by tumor compression is difficult and often unsatisfactory. The case of a 56-year-old female patient in whom self-expanding stents were implanted, successfully enabling oral nutrition, is reported.
Should the Pharmaceutical Industry be Nationalized?
Authors: M. E. Lampard
Journal: BMJ (1965)

MEDIBCAISHRNA,The spleen may remain palpable in glandular fever for ten weeks4 and it has also been recorded as persisting in a child aged 6 weeks for two months.5The spleen in glandular fever is very soft and very friable, and it is apparent that spontaneous rupture can occur and even more so that minimal injury may produce rupture.In the case report by Spink' spontaneous rupture was considered to be due mainly to pressure from within the abdomen and not from pressure without.The patient in that case had denied any injury.
The Pressor Effect of Phenylpropanolamine-Reply
Authors: George L. Blackburn
Journal: JAMA (1989)

In Reply. —  The argument by Drs Pentel and O'Connell states that variability in the response to PPA—especially at higher doses than used in our study— may be associated with a sharp increase in blood pressure in certain individuals. Unfortunately, this conclusion is based on an inadequate sample size. The study by Pentel et al 1 used a crossover design involving 10 healthy subjects and reported 3 (30%) of 10 cases with an increase of at least 20 mm Hg in systolic blood pressure for PPA vs placebo. Similarly, O'Connell et al 2 found such increases in 4 (40%) of 10 cases. The two-sided 95% confidence intervals for these proportions are 7% to 67% for the study by Pentel et al and 11% to 75% for the study by O'Connell et al. Thus, we are uncertain whether this large variation is a true biologic difference in the response to PPA
Allergen Avoidance to Reduce Asthma-Related Morbidity
Authors: Albert L. Sheffer
Journal: New England Journal of Medicine (2004)

Central to the reduction of the severity of allergic disease is a decrease in — and preferably the removal of — the offending environmental allergen. Such allergen avoidance is particularly relevant to the successful treatment of allergic asthma. However, statistically significant reductions in such asthma-inducing allergen concentrations have been difficult to accomplish. Until recently, strategies to reduce exposure to environmental allergens have not decreased asthma-related morbidity. In fact, a meta-analysis failed to demonstrate the efficacy of any environmental-control measures in reducing the severity of asthma.1 Such interventions, however, have usually focused on a single maneuver2 — for example, the use . . .