tbuckley/cabot-search huggingface dataset:
Atlas of Infections of the Skin
Authors: Mark P. Seraly
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes5 October 1999Atlas of Infections of the SkinMark P. Seraly, MDMark P. Seraly, MDUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. (Seraly)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-7-199910050-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Aly R, Maibach HI, eds. 258 pages. New York: Churchill Livingstone; 1999. $170.00. ISBN 0443055874. Order phone 800-543-1918.Field of medicine: Infectious disease and general medicine.Format: Hardcover book.Audience: Family physicians, general internists, public health physicians, dermatologists, infectious disease specialists, medical students, and postgraduate trainees.Purpose: To review common cutaneous fungal, bacterial, and viral skin infections with emphasis on skin structure, pathology, diagnostic techniques, treatment, and differential diagnosis.Content: Common skin infections are reviewed in a concise atlas format. More than 400 clinical photographs and photomicrographs of histologic specimens, smears, and culture plates are included. The uniform outline format ... Author, Article, and Disclosure InformationAffiliations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. (Seraly) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 October 1999Volume 131, Issue 7Page: 555KeywordsClinical pathologyDiagnostic techniquesHuman papillomavirus infectionInfectious diseasesMycosesPrevention, policy, and public healthSkin diseasesSkin infectionsSoftware toolsTreatment guidelines ePublished: 15 August 2000 Issue Published: 5 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Potassium titanyl phosphate laser treatment of resistant port-wine stains
Authors: M.M.U. Chowdhury, S. Harris, S.W. Lanigan
Journal: British Journal of Dermatology (2001)

The pulsed dye laser (PDL; 585 nm, 450 micros pulse) has been established as the treatment of choice for port-wine stains (PWS), but only few patients have total clearance. A modulated potassium titanyl phosphate (KTP) laser (532 nm) has been developed that allows the adjustment of energy fluences within the 5-50 J cm-2 range with laser pulse widths between 1 and 50 ms at pulse rates from 1 to 20 pulses s(-1).To determine the efficacy and side-effect rate of the KTP laser in treating PDL-resistant PWS.Thirty patients were recruited. The site and colour of the PWS were recorded and assessed with erythemameter readings, videomicroscopy and photography both before and after treatment. All patients had test areas treated on their first visit and were then reviewed at 2-monthly intervals. Repeat treatments were given if no adverse effects had occurred and if the treated areas had shown between 25 and 100% lightening.Thirty patients were assessed, age range 11-63 years (mean 35.4) with 19 females. The PWS affected the face in 21 (70%) patients, leg in five (17%) and other sites in four (13%). Patients had one to four tests or treatments (mean 2.2) with the KTP laser. Overall, 16 (53%) patients showed > 25% response and five (17%) showed > 50% response to treatments with the KTP laser. Best responses were found with fluences ranging from 18 to 24 J cm(-2) with pulse width 9-14 ms. No correlation was found with the colour of the PWS or the number of previous treatments with PDL. Patients preferred the KTP laser treatments compared with the PDL (visual analogue score mean 9.8; n = 5) with less discomfort during treatments and minimal purpura post-treatment. Six patients (20%) developed side-effects: scarring (n = 2, 7%), hyperpigmentation (n = 3, 10%) and prolonged healing phase of over 4 weeks (n = 1, 3%).We have shown that the KTP laser can further lighten PDL-resistant PWS and that it is a useful addition to the laser treatment of PWS. Further studies need to assess the efficacy and side-effects of the KTP laser in previously untreated PWS.
Peritoneal Loose Body
Authors: Rachael Sussman, Jonah Murdock
Journal: New England Journal of Medicine (2015)

A 62-year-old man presented with a 20-year history of frequent urination. CT of the abdomen and pelvis revealed a midline mass with central calcification superior to and compressing the bladder. Laparoscopy revealed a free-floating, smooth, firm, rubbery mass.
The Atrophy of Limited Groups of Muscles
Authors: F. Brittan
Journal: BMJ (1857)

cerebral artery-the chief branch of the internal carotid-is directed was much softened, readily breaking down into a pulp, and particularly so was thle left corpus striatum.The other parts of the brain.and likewise the vessels at its base, were found quite healthy in appearance.There was nothing worthy of note to be mentioned concerning the other organs of the body.REMARKS.This case presents some points of interest both in a physiological and in a pathological sense.It appears clear that the arteria innominata was blocked up at the time of the admission of the patient into the Hospital, and for the reasons that the pulse was then imperceptible at the wrist, and that the clot itself was evidently not of recent formation.Consequently the functions of the brain were duly carried on, notwithstand- ing that its supply of blood through this artery was cut off, and .thatnot more than one-fourth of the due amount of blood could have passed through the opening of the left common carotid.Also it is evident, that for the last sixty hours of life the only supply of blood which the brain received was that which passed through the left vertebral artery.The cause of the formation of the clots in the arteria innominata, and in the left cerebral artery, must be, to a certain extent, matter of conjecture.There were no local alterations perceptible in the vessels themselves which could give any account of clots.
UK trial of extracorporeal membrane oxygenation gave biased estimate of efficacy
Authors: F. Shann
Journal: BMJ (1999)

EDITOR—Roberts et al say that extracorporeal membrane oxygenation lowers neonatal mortality at an acceptable cost.1 Their analysis, however, is based on the United Kingdom trial of extracorporeal membrane oxygenation, in which babies were randomised to receive either conventional mechanical ventilation in one of 55 neonatal units or …
THE CULTIVATION OF TRICHOMONAS OF THE HUMAN MOUTH (TETRATRICHOMONAS HOMINIS)
Authors: Tokuzo Ohira, Hideyo Noguchi
Journal: The Journal of Experimental Medicine (1917)

Trichomonades from the mouth were studied by Steinberg who proposed to group them into three distinct types; namely, Trichomonas elongata, Trichomonas caudata, and Trichomonas flagellata. Doflein (3) regards them as probably identical with Trichomonas hominis. Opinions differ as to whether or not Trichomonas vaginalis Donné and Trichomonas hominis Grassi are the same species. Lynch, for instance, believes that they are the same species, while von Prowazek (4), Bensen (5), and others (6, 7) insist that they are different types. Bensen's view seems to be well supported by the difference alleged to be found between the mode of encystment in the two trichomonades, were it not for the fact that our knowledge about the so called cyst of trichomonades is still obscure. According to Alexeieff (8) many of the so called cysts were evidently blastomyces contained in the cell body of the trichomonas. An autogamy alleged to take place in cysts as described by Bohne and von Prowazek (9) has not been confirmed by Dobell (10). And Wenyon (11) contends that it has never been found possible to produce any development of these cysts outside the body on the warm stage as can be done with the cysts of Entamœba coli. Therefore, it is still premature to take the process of encystment into consideration as far as the classification of trichomonas is concerned. On the other hand, Rodenwaldt (12) seems to think that there are many species of trichomonas in the human intestines, and Wenyon has described a new trichomonas from the human intestines (Macrostoma mesnili Wenyon). Further cultural studies in the morphology and biology of these organisms must be carried out in order to solve these problems. In the light of modern investigations there are five subgenera to be included under the genus Trichomonas Donné. They are as follows: (1) Protrichomonas Alexeieff, with three anterior flagella, without an undulating membrane. (2) Trichomastix Biitschli) with three anterior flagella and a trailing flagellum (Schleppgeissel) without an undulating membrane. (3) Trichomonas Donné, with three anterior flagella and an undulating membrane. (4) Macrostoma Alexeieff, Amend, Wenyon (11), with three anterior flagella and an undulating membrane wedged in a deep groove (peristome). (5) Tetratrichomonas Parisi (13), with four anterior flagella and an undulating membrane. As far as our culture trichomonas from the human mouth is concerned, it has been shown that it is not strictly a trichomonas and that it should be classed under the subgenus Tetratrichomonas.
Defining childhood atopic phenotypes to investigate the association of atopic sensitization with allergic disease
Authors: R. J. Kurukulaaratchy, S. Matthews, S. H. Arshad
Journal: Allergy (2005)

Although atopic sensitization is common in childhood, its relationship to clinical allergic disease remains incompletely understood. We therefore sought to explore this relationship by defining sensitization based atopic phenotypes.Children were recruited at birth (n = 1456) and reviewed at 1, 2, 4 and 10 years. Skin prick testing (SPT) to common allergens was done at 4 (n = 980) and 10 years (n = 1036) with lung function (n = 981), bronchial challenge (n = 784) and serum IgE (n = 953) testing at 10. Atopic phenotypes were defined, by sensitization pattern, for children with SPT at both 4 and 10 years (n = 823).Of phenotyped children, 68.0% were never atopic, 4.3% early childhood atopic (only atopic at age 4), 16.5% chronic childhood atopics (at 4 and 10 years) and 11.2% delayed childhood atopics (only at 10). Never atopics showed small but identifiable prevalence of allergic diseases such as asthma, eczema and rhinitis. Amongst allergen-sensitized subjects, aeroallergen predominated over food sensitization throughout childhood. Chronic childhood atopics showed highest prevalence of lifetime plus persistent wheeze, eczema and rhinitis, increased prevalence of aeroallergen sensitization, some evidence of persistent food sensitization, significantly greater cord IgE than never atopics (P = 0.006), plus higher total IgE (P < 0.001) and bronchial hyper-responsiveness (P < 0.001) at 10 years than other phenotypes.A proportion of childhood eczema, rhinitis and asthma is nonatopic. The commonest childhood pattern of atopy is chronic sensitization, associated with early, persisting and clinically significant allergic disease. The currently accepted childhood 'Allergic March' may oversimplify the natural history of childhood atopy and allergic disease.
The Association Between Health Care Quality and Cost
Authors: Peter S. Hussey, Samuel Wertheimer, Ateev Mehrotra
Journal: Annals of Internal Medicine (2013)

Background: Although there is broad policy consensus that both cost containment and quality improvement are critical, the association between costs and quality is poorly understood. Purpose: To systematically review evidence of the association between health care quality and cost. Data Sources: Electronic literature search of PubMed, EconLit, and EMBASE databases for U.S.-based studies published between 1990 and 2012. Study Selection: Title, abstract, and full-text review to identify relevant studies. Data Extraction: Two reviewers independently abstracted data with differences reconciled by consensus. Studies were categorized by level of analysis, type of quality measure, type of cost measure, and method of addressing confounders. Data Synthesis: Of 61 included studies, 21 (34%) reported a positive or mixed-positive association (higher cost associated with higher quality); 18 (30%) reported a negative or mixed-negative association; and 22 (36%) reported no difference, an imprecise or indeterminate association, or a mixed association. The associations were of low to moderate clinical significance in many studies. Of 9 studies using instrumental variables analysis to address confounding by unobserved patient health status, 7 (78%) reported a positive association, but other characteristics of these studies may have affected their findings. Limitations: Studies used widely heterogeneous methods and measures. The review is limited by the quality of underlying studies. Conclusion: Evidence of the direction of association between health care cost and quality is inconsistent. Most studies have found that the association between cost and quality is small to moderate, regardless of whether the direction is positive or negative. Future studies should focus on what types of spending are most effective in improving quality and what types of spending represent waste. Primary Funding Source: Robert Wood Johnson Foundation.
An Essay on Scientific Surgery, the Antiseptic Method of Lister in the Present and in the Future
Authors: None Lucas-Championniere
Journal: BMJ (1902)

TM 2*ryA% 1819 disturbed for six or eight days.I have even attempted to operate on cases at an advanced stage of the disease, without the preliminary establishment of an artificial anus.I confess that I have repeatedly gone too far, and have had ill results in consequence.Of late years my radical operations have been confined to small and movable cancers, and since then my immediate results have been much more favourable.From i888 to I899-that is to say in the course of eleven, years-I carried out 125 radical operations for cancer of the rectum.In 6o of these 125 cases excision of the rectum, in 65 cases resection, was performed.Among the 6o excisions of the rectum the coccyx and part of the sacrum were re- moved eight times, the coccyx alone was extirpated twenty- one times, whilst seventeen excisions were performed without any bone operation.In about half these cases the peritoneum was laid open.Nine of the 6o patients died shortly after, the operation.In no case was death caused by either infec- tion, peritonitis, or cellulitis of the pelvis.Seven patients died in collapse, in one case decubitus with an early recur- rence and a severe cystitis, and in another an iembolus of the
Obscured Bone Metastases After Administration of Hematopoietic Factor on FDG-PET
Authors: Avneesh Chhabra, Kiran Batra, P Todd Makler
Journal: Clinical Nuclear Medicine (2006)

We describe interesting imaging features on a FDG-PET scan in a patient with bony metastases from a rare tumor. The lesions were obscured by intense bone marrow activity after the administration of hematopoietic factor at the time of diagnosis. Correlative MRI, CT scan, and pathology findings have also been illustrated. Follow-up FDG-PET scan demonstrated the hypermetabolic lesions.
Ethnic Distribution of Factor V Leiden in 4047 Men and Women
Authors: Paul M. Ridker
Journal: JAMA (1997)

<h3>Objective.</h3> —To estimate ethnic-specific prevalence rates of factor V Leiden, an inherited defect of hemostasis associated with risk of venous thrombosis. <h3>Design.</h3> —Survey of 4047 American men and women participating in the Physicians' Health Study (PHS) or in the Women's Health Study (WHS). All study participants were free of myocardial infarction, stroke, or venous thrombosis. <h3>Main Outcome Measure.</h3> —Prevalence of<i>G1691A</i>Leiden mutation in the gene coding for coagulation factor V was determined in the PHS group using polymerase chain reaction techniques and, in the WHS group, a second-generation activated protein C (APC)—resistance screening test with genetic confirmation of all borderline and low-value results. <h3>Results.</h3> —In 2468 Caucasian Americans, carrier frequency of factor V Leiden was 5.27% (95% confidence interval [CI], 4.42%-6.22%). Carrier frequency was 2.21% in 407 Hispanic Americans, 1.23% in 650 African Americans, 0.45% in 442 Asian Americans, and 1.25% in 80 Native Americans. Thus, prevalence of factor V Leiden was less among minority subjects (<i>P</i>=.001). Carrier frequencies were similar in Caucasian men and women (5.53% vs 4.85% respectively,<i>P</i>=.5). <h3>Conclusion.</h3> —These data indicate that prevalence of factor V Leiden is greater among Caucasians than minority Americans. These data have implications for clinicians considering whether to screen for factor V Leiden in high-risk groups such as those with prior venous thromboses or coexistent defects of anticoagulation and women at risk for postpartum thrombosis or seeking oral contraceptives.
Cystic Nephroma and Mixed Epithelial and Stromal Tumour of the Kidney: Opposite Ends of the Spectrum of the Same Entity?
Authors: Rodolfo Montironi, Roberta Mazzucchelli, Antonio Lopez-Beltran, Guido Martignoni, Liang Cheng, Francesco Montorsi, Marina Scarpelli
Journal: European Urology (2007)
Publicity about certain aspects of meningococcal disease is still needed
Authors: A Corke, M Davda, V Franklin, J Taylor, R Anderson, J Bhachu, S Chen, N Choudbury, T Christmas
Journal: BMJ (1996)

FceRI-P polymorphisms unlikely to contribute substantially to genetic risk of allergic disease EDITOR,-M R Hill and colleagues report the association between a variant of the gene for the 1B chain of the high affinity receptor for IgE (FCeRI-O) with the Leu 181/Leu 183 polymorphism and atopy in an Australian population.'They suggest that polymorphism in FcsRI-is one factor that can be used to assign genetic risk of atopy.This group has previously suggested that Leu 181 may be associated with atopy in the British population.2As part ofa study examining the relation between 12 adrenoceptor polymorphisms and airway reactivity3 we recently screened a population of asthmatic patients for FcERI-3 polymorphisms.Polymerase chain reaction based on the amplification refractory mutation system failed to identify any subjects with either the Leu 181 or the Leu 181/ Leu 183 polymorphism.We therefore proceeded to direct sequencing of this region of FcsRI-to ensure that our ability to detect the Leu 181 polymorphism was not due to problems with the method.None of our 65 asthmatic subjects, however, had either the Leu 181 or the Leu 183 substitution on direct sequencing.Of these 65 subjects, 41 fulfilled Hill and colleagues' criteria for atopy, although all had a 20% fall in forced expiratory volume in one second after challenge with methacholine.These results suggest that, while FcsRI-P polymorphisms may contribute to the atopic phenotype in defined populations, they are unlikely to contribute substantially to the genetic risk of allergic disease in the population at large.
Chemotherapy in Stage I Breast Cancer
Authors: George E. Moore
Journal: JAMA (1967)

The question of the role of adjuvant chemotherapy for so-called stage I breast cancers is easy to answer: there is none. A large cooperative study on breast cancer produced data supporting the thesis that recurrence was delayed by adjuvant chemotherapy with thiotepa given in conjunction with radical mastectomy.<sup>46</sup>In some ways the study was defective, partially as a result of factors external to the design and conduct of the investigation. A second more comprehensive and better designed study has been under way since October 1961. This study has features which do not permit publication of critical information until completion of the study unless an adverse effect was noted. From a theoretical standpoint, patients with stage I lesions (determined by pathologic examination) are the ones most apt to benefit from receiving effective systemic therapy in conjunction with excision of the primary lesion. Proof of this thesis will be difficult. First,
Clinical Alerts: Broder Discusses Pros and Cons On the Record
Authors: C. K. Wittenberg
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Clinical Alerts: Broder Discusses Pros and Cons On the Record Get access Clarissa K. Wittenberg Clarissa K. Wittenberg Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 24, 19 December 1990, Pages 1876–1877, https://doi.org/10.1093/jnci/82.24.1876 Published: 19 December 1990
In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis
Authors: Orlando Musso, Nathalie Théret, Jean Pierre Campion, Bruno Turlin, Stefano Milani, Cecilia Grappone, Bruno Clément
Journal: Journal of Hepatology (1997)
918 CLEVUDINE DEMONSTRATES POTENT ANTIVIRAL ACTIVITY IN THE NAIVE CHRONIC HEPATITIS B PATIENTS
Authors: June Sung Lee, E.T. Park, S.S. Kang, E.S. Gu, J.S. Kim, D.S. Jang, K.S. Lee, Jae-Su Lee, N.H. Park, C.H. Bae, S.K. Baik, B.J. Yu, S.H. Lee, E.J. Lee, S.I. Park, M. Bae, J.W. Shin, J.H. Choi, C. Gu, S.K. Moon, G.J. Chun, J.H. Kim, H.S. Kim, S.K. Choi
Journal: Journal of Hepatology (2009)
Hemodynamic effects of a combination of vasopressin and ketanserin in patients with hepatitis B-related cirrhosis
Authors: Fa-Yauh Lee, Yang-Te Tsai, Han-Chieh Lin, Shou-Dong Lee, Hsiao-Chung Hsia, Wen-Jeh Lin, Sun-Sang Wang, Kwok-Hung Lai, Kwang-Juei Lo
Journal: Journal of Hepatology (1992)
868-3 Comparison of left ventricular sphericity and papillary muscle tethering in the mechanism of ischemic mitral regurgitation in patients with inferior myocardial infarction
Authors: Takeshi Uemura, Yutaka Otsuji, Toshiro Kumanohoso, Kunitsugu Takasaki, Toshinori Yuasa, Kenichi Nakashiki, Bo Yu, Akira Kisanuki, Shinichi Minagoe, Robert A Levine, Chuwa Tei
Journal: Journal of the American College of Cardiology (2004)
Changes in Sickness at Admission Following the Introduction of the Prospective Payment System
Authors: Emmett B. Keeler
Journal: JAMA (1990)

We developed disease-specific measures of sickness at admission based on medical record data to study mortality of Medicare patients with one of five conditions (congestive heart failure, acute myocardial infarction, cerebrovascular accident, pneumonia, and hip fracture). We collected an average of 73 sickness variables per disease, but our final sickness-at-admission scales use, on average, 19 variables. These scales are publicly available, and explain 25% of the variance in 30-day postadmission mortality for patients with acute myocardial infarction, pneumonia, or cerebrovascular accident. Sickness at admission increased following the introduction of the prospective payment system (PPS). For our five diseases combined, the 30-day mortality to be expected because of sickness at admission was 1.0% higher in the 1985-1986 period than in the 1981-1982 period (16.4% vs 15.4%), and the expected 180-day mortality was 1.6% higher (30.1% vs 28.5%). Studies of the effects of PPS on mortality must take this increase in sickness at admission into account. (<i>JAMA</i>. 1990;264:1962-1968)
Cognitive modelling of human temporal reasoning
Authors: Alice G. B. ter Meulen
Journal: Behavioral and Brain Sciences (2003)

Modelling human reasoning characterizes the fundamental human cognitive capacity to describe our past experience and use it to form expectations as well as plan and direct our future actions. Natural language semantics analyzes dynamic forms of reasoning in which the real-time order determines the temporal relations between the described events, when reported with telic simple past-tense clauses. It provides models of human reasoning that could supplement ACT-R models.
A Case of Secondary Syphilitic Iridocyclitis
Authors: R. J. Buxton
Journal: BMJ (1946)

catch in her axilla, and that almost immediateiy her whole arm began to swell and felt useless, tight, and tense.There was no previous history of a similar condition.On examination her general condition was seen to be good.Her temperature was 98°F.(36;7°C.), and her pulse rate 70.