tbuckley/cabot-search huggingface dataset:
Interventional Treatment for Children With Severe Coronary Artery Stenosis With Calcification After Long-term Kawasaki Disease
Authors: Tetsu Sugimura, Hiroyoshi Yokoi, Noboru Sato, Teiji Akagi, Takeshi Kimura, Motohumi Iemura, Masakiyo Nobuyoshi, Hirohisa Kato
Journal: Circulation (1997)

About 4% of children with Kawasaki disease (KD) eventually develop ischemic heart disease, which is often associated with calcified stenosis. We assessed the utility of the percutaneous transluminal coronary rotational ablation (PTCRA) in children with coronary artery stenosis after KD.Four children (three boys and one girl; age, 12 to 13 years) with coronary artery stenosis underwent percutaneous transluminal coronary angioplasty (PTCA) and PTCRA 11.8+/-0.9 years after the onset of KD. Morphology of the coronary artery wall was evaluated by intravascular ultrasound imaging. In one patient, the targeted lesion for intervention was in the left anterior descending artery (90% stenosis); in the other three patients, it was in the middle of the right coronary artery (75% to 90% stenosis). PTCA failed in three patients because of severe stenosis with calcification. However, PTCRA proved effective, with stenosis rates reduced from 90% to 25%. Follow-up coronary angiography performed 4 months after the procedure demonstrated no restenosis, but mild aneurysms occurred in two patients.This study suggests that PTCRA is useful for revascularizing coronary arteries with severe stenosis and calcification as long-term sequelae of KD. Intravascular ultrasound imaging is useful in assessing the coronary artery wall pathology and in selecting the best treatment intervention.
Handbook of Psychosomatic Medicine
Authors: Karen B. Kreiner
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes5 January 1999Handbook of Psychosomatic MedicineKaren B. Kreiner, MDKaren B. Kreiner, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00041 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Fava GA, Freyberger H; eds. 780 pages. Madison, CT: International Universities Pr; 1998. $76.50. ISBN 0823623025. Order phone 800-835-3487.Field of medicine: Psychosomatic medicine.Format: Hardcover book.Audience: Practitioners in every specialty, particularly primary care practitioners and psychiatrists in the field of consultation-liaison psychiatry.Purpose: To provide a comprehensive, up-to-date review of psychosomatic medicine.Content: This handbook was compiled from 32 review papers written for the journal Psychotherapy and Psychosomatics. In more than 700 pages, the authors attempt to cover a broad, complex subject. The book is divided into three sections: fundamental trends in the field, clinical issues, and treatment ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 January 1999Volume 130, Issue 1Page: 88KeywordsComputed axial tomographyComputer software ePublished: 15 August 2000 Issue Published: 5 January 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Nifuratel for trichomonal vaginitis.
Authors: A Grimble, D J Wright
Journal: BMJ (1970)

SIR,-Your leading article on Crohn's Disease and its Consequences (11 April p. 65) says "Psychological factors are gener- ally held not to be aetiologically important" and cites to support such a "generally held" view but one reference, and that to an article which has been much criticised on account of its methodology.Dare I suggest that such selectivity if practised by psychiatrists would quite prop- erly call down the wrath of medical science?To redress the balance I draw your atten- tion to a few recent articles giving the opposite view.'-'-I am, etc.,
Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis
Authors: Shimpei Kawamoto, Mikako Maruya, Lucia M. Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, Sidonia Fagarasan
Journal: Immunity (2014)
Waiting in Hospitals — Holidays in Britain Philosophy of the First Rate
Authors: John Lister
Journal: New England Journal of Medicine (1953)

ABRISK correspondence developed recently in the Daily Telegraph after a layman's letter commenting on the time a patient wastes in hospital outpatient departments and suggesting certain reforms. The writer stated that patients have to wait for periods varying from half an hour to half a day. A recent investigation had shown that the average waiting time for a patient from the time of his appointment to the time of his seeing a doctor was fifty-five minutes. Other periods of waiting followed for x-ray examinations, blood tests, form filling and social-service interviews. The correspondent stated that the same investigation had shown . . .
Infection and Fibrositis
Authors: D. H. Collins
Journal: Annals of the Rheumatic Diseases (1940)

DEFINITION OF FIBROSITISIT is traditional and etymologically correct to define fibrositis as an inflammation of fibrous tissue; but this is an inadequate definition of the clinical state to which the name applies.It is not yet established that inflammation is the only process, or fibrous tissue the only tissue, concerned in the pathogenesis of the disease.Fibrositis must therefore be defined afresh in clinical terms.It may then be clear that the subsequent dis- cussion concerns a familiar clinical condition without assuming any uniform and established pathology for it.Fibrositis, then, is an acute or chronic painful state of the subcutaneous tissues, muscles, fasciae, ligaments or tendons, arising independently of gross anatomical disease from which pain might be referred.The pain of fibrositis has the more or less uniform quality which Lewis' attributes to all pains arising from deep somatic structures, irrespective of the nature of their stimulus.It is felt both locally at certain tender points and referred according to segmental distribution (Kellgren2).The painful state of fibrositis is sometimes, but not invariably, associated with localised indurations or nodules palpable through the skin, and these frequently coincide with points of maximum tenderness.These so-called fibrositic nodules can sometimes be dispersed by massage and, if they are the focal points from which the pain originates, relief and even permanent cure of the symptoms can often be obtained by infiltrating them with local aneTsthetic.GENERAL AETIOLOGY OF FIBROSITIS Fibrositis is usually classed as a rheumatic disease, and the numerous and varied setiological factors attributed to other rheumatic diseases have also been assigned to it-e.g., climate, occupation, trauma, endocrine disturbances, the " rheumatic diathesis ", psychoneurotic states, and infection.The last only will be considered in detail here.There are good grounds for
REPORT OF A CASE OF HYDROPHOBIA
Authors: ALFRED HAND
Journal: JAMA (1913)

Physicians are called so frequently to treat patients who have been bitten by dogs, and so rarely to treat patients with hydrophobia or rabies, that it is not surprising to find some of the profession asserting that the disease does not exist in human beings. It becomes a duty therefore to report well-authenticated cases like the following:  K. N., a girl aged 5, was bitten in the cheek by a dog. The wound healed promptly.  Seventeen days later the child complained of feeling ill, and developed moderate fever, anorexia, constipation and mild delirium. On the next day the delirium increased so that she was restrained with difficulty. The father also stated that the sight of water made her crazy and that there was some frothing at the mouth; but these symptoms were not present on her admission to the Children's Hospital on the third day of the disease.  Examination on
Sunlight-induced cancer: some new aspects and implications of the xeroderma pigmentosum model
Authors: A. R. LEHMANN, B. A. BRIDGES
Journal: British Journal of Dermatology (1990)

Journal Article Sunlight‐induced cancer: some new aspects and implications of the xeroderma pigmentosum model Get access A. R. LEHMANN, A. R. LEHMANN MRC Cell Mutation Unit, Sussex University, Brighton, U.K. ; Dr A. R. Lehmann, MRC Cell Mutation Unit, Sussex University, Falmer, Brighton BNI 9RR, U.K. Search for other works by this author on: Oxford Academic Google Scholar B. A. BRIDGES B. A. BRIDGES MRC Cell Mutation Unit, Sussex University, Brighton, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue s35, 1 April 1990, Pages 115–119, https://doi.org/10.1111/j.1365-2133.1990.tb16136.x Published: 01 April 1990
Effects of Acidosis on the Performance and Metabolism of the Anoxic Heart
Authors: THEODORE R. GELET, RUTH A. ALTSCHULD, ARNOLD M. WEISSLER
Journal: Circulation (1969)

The present studies on the isolated rat heart perfused at constant rate (10 ml per minute) with 5% albumin in KRB were designed to investigate the influence of increased extracellular H+ ion on the pacemaker and contractile performance and the anaerobic metabolism of the anoxic heart. During anoxia, (96% N 2 , 4% CO 2 ) at pH 7.4 in the presence of anaerobic substrate (glucose 200 mg/100 ml) the isolated heart performed spontaneously for 30 minutes. During this period there was active anaerobic lactate production (0.84 mM/30 min/gm of protein), whereas the myocardial content of ATP and total adenine nucleotides was significantly reduced when compared to aerobic control levels. Diminution in anoxic perfusate to pH 7.0, accomplished by addition of HCl, resulted in a significant depression of cardiac pacemaker activity and left ventricular contractile performance unassociated with a diminution in myocardial anaerobic lactate production, ATP, or total nucleotide content when compared to pH 7.4. During anoxia at pH 6.6 there was a marked decrement in cardiac pacemaker activity and ventricular performance, associated with slight diminution in anaerobic lactate production, ATP, and total nucleotide content of the myocardium when compared to pH 7.4. The data demonstrate that the decrement in function of the anoxic heart imposed by increasing extracellular hydrogen ion concentration to pH 7.0 does not primarily involve suppression of glycolytic activity. Only at pH 6.6, when cardiac performance is markedly suppressed, could evidence for diminished anaerobic glycolysis be elicited. These observations are consistent with the thesis that increased hydrogen ion concentration dominantly affects the energy utilization phase of cardiac metabolism.
Abstract B34: IKKalpha regulation of mTORC1 and modulation of prostate tumorigenesis through phosphorylation of mTOR
Authors: Hancai Dan, Albert S. Baldwin
Journal: Cancer Research (2012)

Abstract The mammalian target of rapamycin (mTOR) is a critical mediator of cell growth, cell proliferation, survival, and energy metabolism. mTOR is activated downstream of growth factors, insulin, and Akt-dependent signaling associated with oncoprotein expression or loss of the tumor-suppressor PTEN. In this regard, mTOR activity is associated with cancer cell growth and survival. Here, we have explored an involvement of the I kappa B kinase (IKK) pathway, associated with nuclear factor-kappaB activation, in controlling mTOR activity. The experiments show that IKK alpha controls mTOR activity in Akt-active, PTEN-null prostate cancer cells by directly phosphorylation of mTOR at Serine 1415. In these cells, IKK alpha associates with mTORC1 and weaken the association between mTOR and Raptor, an important component of mTORC1, to increase mTORC1 kinase activity by phosphorylation in an Akt-dependent manner. Additionally, IKKalpha phosphorylation of mTOR is required for efficient induction of cell proliferation downstream of constitutively active Akt in these cells. The results indicate a novel role for IKKalpha in controlling mTOR function in protate cancer cells with loss of PTEN and constitutive Akt activity. Citation Format: Hancai Dan, Albert S. Baldwin. IKKalpha regulation of mTORC1 and modulation of prostate tumorigenesis through phosphorylation of mTOR [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr B34.
No place like home?
Authors: J. Davis
Journal: BMJ (1981)

<h3>Summary</h3> Over the last 25 years, lung transplantation has developed into a well-established treatment option for selected patients with very advanced lung disease. In 2010, over a 12-month period, more than 3500 new lung transplant procedures were reported to the International Society of Heart and Lung Transplantation (ISHLT) Registry [1]. In 2011, 1830 lung transplants were performed in the USA [2]. In 2012, 690 were performed in the “Eurotransplant” region [3] and a further 170 within the UK [4]. New transplant programmes are now being established around Europe, increasing access to this life saving intervention and benefitting from sharing experience with more established centres. Although worldwide activity has increased year on year over the last decade (fig. 1), demand has also increased meaning the significant shortage of suitable donor lungs accounts for an unacceptably high waiting list mortality rate in many countries. Clinical experience shared between transplant centres worldwide has helped refine the assessment process so that those added to a waiting list are those who are most likely to benefit. Furthermore, a meticulous approach to post-transplant management in the immediate post-operative period, in the early and long-term has contributed to continually improving long-term survival after lung transplantation.
Abstract 635: PARP inhibition in HPV positive head and neck cancers.
Authors: Tiffiny Cooper, Marcela Rodriguez, Hoa Q. Trummell, Alice Weaver, James A. Bonner, Eddy S. Yang
Journal: Cancer Research (2013)

Abstract Purpose: The human papilloma virus (HPV) has recently become a prevalent cause of human head and neck cancer (HNC), which often exhibits dysregulated epidermal growth factor receptor (EGFR) signaling. We previously reported that in non-HPV-associated HNC, inhibition of EGFR (EGFRi) attenuates DNA double stranded break (DSB) repair and subsequently sensitizes tumors to inhibitors of poly (ADP-ribose) polymerase (PARP), which target DNA repair deficient tumors. Because patients with HPV-associated HNC have been shown to exhibit increased sensitivity to DNA damage, we evaluated the response of HPV (+) HNC cells to combination EGFRi and PARPi compared to HPV (-) HNC cells. Methods: HPV (-) UM-SCC1 and UM-SCC6, as well as HPV (+) SCC-47 and SCC-90 were utilized for in vitro studies. Cell growth and survival fraction were evaluated via cell proliferation and colony formation assays, respectively. DNA damage studies were performed using standard γ-H2AX and Rad51 foci. Lastly, in vivo studies were conducted in mice bearing HNC tumor xenografts as well as a human tumor explant from a lymph node metastasis of a HPV(+) HNC patient. Results: Interestingly, HPV (+) HNCs exhibited the greatest sensitivity both in vitro and in vivo to PARP inhibition alone. This correlated with a blunted DNA damage response. In contrast, HPV (-) HNCs were most sensitive to combination EGFRi/PARPi, which correlated with persistent DNA damage. Conclusions: HPV(+) head and neck cancers may be sensitive to PARP inhibition alone. Our in vitro and in vivo results warrant further testing of PARP inhibitors as part of therapy for HNCs. Citation Format: Tiffiny Cooper, Marcela Rodriguez, Hoa Q. Trummell, Alice Weaver, James A. Bonner, Eddy S. Yang. PARP inhibition in HPV positive head and neck cancers. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 635. doi:10.1158/1538-7445.AM2013-635
Phylogenetic analysis of Lymnaeid snails based on 18S rDNA sequences
Authors: M. D. Bargues, S. Mas-Coma
Journal: Molecular Biology and Evolution (1997)

The 18S rDNA sequences of the six most common European Lymnaeidae species (Mollusca:Gastropoda:Basommatophora) have been obtained by direct PCR cycle sequencing and silver staining methods. The sequence alignment and secondary structures of the 18S rRNA gene of Lymnaea stagnalis, L. auricularia, L. peregra, L. palustris, L. glabra, and L. truncatula are analyzed. This gene proves to be a good marker for both specific determination and supraspecific lymnaeid phylogeny. The malacological importance is evident, considering the specific determination problems of individual snails and the present systematic chaos in Lymnaeidae due to their pronounced morphoanatomic uniformity, which makes a classification by traditional methods impossible. The majority (17) of the total of 43 nucleotide-substituted positions appears to be confined to a small region included in helix E10-1 of the variable region V2, enabling species group distinction: (1) the first sequence is common to L. auricularia and L. peregra; (2) the second sequence is unique to L. truncatula; and (3) the third sequence is identical for L. glabra, L. palustris, and L. stagnalis. The other 26 nucleotide-substituted positions are dispersed over the entire gene, although four grouped nucleotide positions in helix 6 of V1 are of interest in distinguishing L. glabra from both L. palustris and L. stagnalis. The phylogenetic trees obtained by comparison with four other molluscan species (a polyplacophoran, two bivalves, and a stylommatophoran gastropod) show the presence of four well-defined subgenera among the genus Lymnaea sensu lato: (1) Lymnaea (Radix), (2) Lymnaea (Galba), (3) Lymnaea (Leptolimnaea), and (4) Lymnaea (Lymnaea). Two branches, L. auricularia-L. peregra-L. truncatula and L. glabra-L. palustris-L. stagnalis, are worth mentioning from the parasitological point of view, since the two digenean species of large medical and veterinary impact transmitted by lymnaeids, Fasciola hepatica and F. gigantica, appear to be linked to the first branch.
Increased Myogenic Tone and Diminished Responsiveness to ATP-Sensitive K <sup>+</sup> Channel Openers in Cerebral Arteries From Diabetic Rats
Authors: Paul A. Zimmermann, Harm J. Knot, Andrá S. Stevenson, Mark T. Nelson
Journal: Circulation Research (1997)

Abstract Diabetes mellitus has profound adverse effects on vascular and, in particular, endothelial function. Although pressure-induced constriction (“myogenic tone”) is a major contributor to the regulation of blood flow, little is known about the effects of diabetes on this response. Diabetes has been shown to diminish the dilation of cerebral arteries to synthetic ATP-sensitive K + (K ATP ) channel openers. In this study, we explored the effects of diabetes induced in rats by streptozotocin on cerebral artery (250 to 300 μm) myogenic tone and on vasodilations to the synthetic K ATP channel openers pinacidil and levcromakalim. Elevation of intravascular pressure caused a graded membrane potential depolarization and constriction, which was greater in arteries from diabetic rats compared with normal rats (at 60 mm Hg, 5 mV more depolarized and 22 μm more constricted). Pressurized arteries (at 60 mm Hg) from diabetic rats were 5- to 15-fold less sensitive to pinacidil and levcromakalim than were control arteries (EC 50 values for pinacidil and levcromakalim were 1.4 and 0.6 μmol/L, respectively, in diabetic animals and 0.3 and 0.04, respectively, in control animals; P &lt;.05). Removal of the endothelium or addition of a NO synthase inhibitor, N G -nitro- l -arginine (LNNA), in control arteries decreased the sensitivity to K ATP channel openers and depolarized and constricted control arteries to levels similar to those observed in arteries from diabetic animals. Sodium nitroprusside caused a membrane potential hyperpolarization and enhanced the response to pinacidil in arteries from diabetic animals. Removal of the endothelium or LNNA had little effect on the apparent K ATP channel opener sensitivity, the membrane potential, and pressure-induced constrictions of arteries from diabetic animals. The results are consistent with the hypothesis that this type of diabetes leads to a decrease in tonic NO release from the endothelium, which in turn causes membrane potential depolarization and vasoconstriction, resulting in a diminished response to K ATP channel openers.
Medical Council of India recommends removal of 25 doctors from medical register for falsely claiming to be faculty members
Authors: P. Chatterjee
Journal: BMJ (2012)

The Medical Council of India (MCI), which regulates medical education, has recommended the removal of 25 doctors from the Indian Medical Register and state medical registers for periods ranging from three to five years “for providing misleading information regarding their working as full time faculty.”

Twenty five doctors, registered with medical councils in several states across the country, are under fire from the council’s ethics committee for falsely claiming to be full time faculty members of the Melmaruvathur Adiparasakthi Institute of Medical Sciences and Research, a private institution in Tamil Nadu.

The council was following up a report by India’s Central Bureau of Investigation (CBI). Public health advocates have welcomed the council’s latest move. But they say that cracking the problem of fake faculty members is not going to be …
Problems in Diagnosing Osteoarticular Tuberculosis
Authors: David D. Hunt
Journal: JAMA (1964)

Five patients with osteoarticular tuberculosis were presented as diagnostic problems because each was initially thought to have some other disease. Several factors were cited as reasons for the delay, including unusual sites of involvement, the lack of detectable pulmonary involvement, secondary pyogenic infections, and the absence of classical roentgenographic signs. A more general factor is attributable to a decrease in the incidence of tuberculosis in this country and alterations in the method of handling patients with this disease. In addition, there has been some evidence, supported by these cases, that the pattern of osteoarticular tuberculosis may be changing.
VEGETABLE MARROW AS A CAUSE OF POSITIVE BENZIDINE TESTS IN THE STOOLS OF DIABETIC PATIENTS
Authors: Joseph C. Massee
Journal: JAMA (1926)

In the routine laboratory examinations at the Peter Bent Brigham Hospital, it was observed that a large number of diabetic patients in whom there was no reason to suspect a pathologic condition of the gastro-intestinal tract showed a positive benzidine test for occult blood in the feces. It was believed that some other factor than the meat in the diabetic diet might be the cause of this positive reaction, since a larger proportion of diabetic patients than other patients on diets containing meat seemed to give a positive test. Accordingly, various articles in the diets commonly given to diabetic patients were tested both by the benzidine and by the guaiac test. In this way it was found that in addition to the meats a certain vegetable, English marrow, gave apositive benzidine and guaiac test. This marrow has been largely used in diabetic diets because of its bulk