A Good Night's Sleep: Future Antidote to the Obesity Epidemic?
Authors: Jeffrey S. Flier, Joel K. Elmquist
Journal: Annals of Internal Medicine (2004)

Editorials7 December 2004A Good Night's Sleep: Future Antidote to the Obesity Epidemic?Jeffrey S. Flier, MD and Joel K. Elmquist, DVM, PhDJeffrey S. Flier, MDFrom Beth Israel Deaconess Medical Center, Boston, MA 02215. and Joel K. Elmquist, DVM, PhDFrom Beth Israel Deaconess Medical Center, Boston, MA 02215.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-11-200412070-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It is well established that the prevalence of obesity has been increasing over recent decades, both in the United States and the rest of the developed world. Why is this happening? Body weight is physiologically regulated, and this regulation involves a complex physiologic system encoded by an array of specific genes (1). This system involves both central and peripheral components and interacts with aspects of the environment, such as availability and composition of the diet and the need for physical exercise, to influence body weight. Although genes play a critical role in weight determination, the increased prevalence in obesity of ...References1. Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell. 2004;116:337-50. [PMID: 14744442] CrossrefMedlineGoogle Scholar2. Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004;141:846-50. LinkGoogle Scholar3. Williams DL, Grill HJ, Cummings DE, Kaplan JM. Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology. 2003;144:5184-7. [PMID: 14525914] CrossrefMedlineGoogle Scholar4. 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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98:437-51. [PMID: 10481909] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jeffrey S. Flier, MD; Joel K. Elmquist, DVM, PhDAffiliations: From Beth Israel Deaconess Medical Center, Boston, MA 02215.Disclosures: None disclosed.Corresponding Author: Jeffrey S. Flier, MD, Division of Endocrinology, Beth Israel Deaconess Medical Center, Finard 202, 330 Brookline Avenue, Boston, MA 02215; e-mail, [email protected]harvard.edu.Current Author Addresses: Drs. Flier and Elmquist: Division of Endocrinology, Beth Israel Deaconess Medical Center, Finard 202, 330 Brookline Avenue, Boston, MA 02215. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBrief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite Karine Spiegel , Esra Tasali , Plamen Penev , and Eve Van Cauter Metrics Cited byConcussive head injury exacerbates neuropathology of sleep deprivation: Superior neuroprotection by co-administration of TiO2-nanowired cerebrolysin, alpha-melanocyte-stimulating hormone, and mesenchymal stem cellsLong working hours and overweight and obesity in working adultsDo Working Hours and Type of Work Affect Obesity in South Korean Female Workers? 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