tbuckley/cabot-search huggingface dataset:
The Attributable Mortality and Costs of Primary Nosocomial Bloodstream Infections in the Intensive Care Unit
Authors: BRUNO DiGIOVINE, CAROL CHENOWETH, CHARLES WATTS, MILLICENT HIGGINS
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Primary nosocomial bloodstream infection (BSI) is a common occurrence in the intensive care unit (ICU) and is associated with a crude mortality of 31.5 to 82.4%. However, an accurate estimate of the attributable mortality has been limited because of confounding by severity of illness. We undertook this study to assess the attributable mortality and costs associated with an episode of BSI. Infected patients were defined as those who had an episode of BSI during the study period. Uninfected control subjects were matched to the infected patients based upon a number of factors, including predicted mortality on the day prior to infection. The main outcome measures were crude ICU mortality, length of stay, and costs. We found no difference in the crude mortality for the infected and the uninfected patients (35.3 and 30.9%, respectively, p = 0.51). However, among survivors, the patients with nosocomial bloodstream infections did have excess length of stay (mean, 10 d; median, 5 d; p = 0.007) and increased direct costs (mean difference, $34,508; p = 0.008). After matching for severity of illness, we could not detect an association between primary nosocomial bloodstream infections and increased ICU mortality. We did find that primary nosocomial bloodstream infections increased ICU length of stay and costs.
Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN
Authors: Yoshiharu Nishitani, Masayuki Iwano, Yukinari Yamaguchi, Koji Harada, Kimihiko Nakatani, Yasuhiro Akai, Toshihiko Nishino, Hideo Shiiki, Masao Kanauchi, Yoshihiko Saito, Eric G. Neilson
Journal: Kidney International (2005)
The Aging Kidney in Health and Disease
Authors: Edgar V. Lerma
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outpatient Radioiodine Therapy for Thyroid Cancer
Authors: José Willegaignon, Marcelo Sapienza, Carla Ono, Tomoco Watanabe, Maria Inês Guimarães, Ricardo Gutterres, Maria Helena Marechal, Carlos Buchpiguel
Journal: Clinical Nuclear Medicine (2011)

Purposes: To evaluate the dosimetric effect of outpatient radioiodine therapy for thyroid cancer in members of a patient's family and their living environment, when using iodine-131 doses reaching 7.4 GBq. The following parameters were thus defined: (a) whole-body radiation doses to caregivers, (b) the production of contaminated solid waste, and (c) radiation potential and surface contamination within patients' living quarters. Methods: In total, 100 patients were treated on an outpatient basis, taking into consideration their acceptable living conditions, interests, and willingness to comply with medical and radiation safety guidelines. Both the caregivers and the radiation dose potentiality inside patients' residences were monitored by using thermoluminescent dosimeters. Surface contamination and contaminated solid wastes were identified and measured with a Geiger-Müller detector. Results: A total of 90 monitored individuals received a mean dose of 0.27 (±0.28) mSv, and the maximum dose registered was 1.6 mSv. The mean value for the potential dose within all living quarters was 0.31 (±0.34) mSv, and the mean value per monitored surface was 5.58 Bq/cm2 for all the 1659 points measured. The overall production of contaminated solid wastes was at a low level, being about 3 times less than the exemption level indicated by the International Atomic Energy Agency. Conclusions: This study indicates that the treatment of thyroid cancer by applying radioiodine activities up to 7.4 GBq, on an outpatient basis, is a safe procedure, especially when supervised by qualified professionals. This alternative therapy should be a topic for careful discussion considering the high potential for reducing costs in healthcare and improving patient acceptance.
COMPARISON OF DRUG ELUTING STENT AND BARE METAL STENT IN ST ELEVATION MYOCARDIAL INFARCTION AT FOLLOW-UP OF 2 YEARS OR LONGER: A META-ANALYSIS OF RANDOMIZED TRIALS
Authors: Ankur Sethi, Amol Bahekar, Rohit Bhuriya, Aziz Ahmed, Sandeep Khosla
Journal: Journal of the American College of Cardiology (2011)
Lipoprotein binding to cultured human hepatoma cells.
Authors: F Krempler, G M Kostner, W Friedl, B Paulweber, H Bauer, F Sandhofer
Journal: Journal of Clinical Investigation (1987)

Binding of various 125I-lipoproteins to hepatic receptors was studied on cultured human hepatoma cells (Hep G2). Chylomicrons, isolated from a chylothorax, chylomicron remnants, hypertriglyceridemic very low-density lipoproteins, normotriglyceridemic very low-density lipoproteins (NTG-VLDL), their remnants, low-density lipoproteins (LDL), and HDL-E (an Apo E-rich high-density lipoprotein isolated from the plasma of a patient with primary biliary cirrhosis) were bound by high-affinity receptors. Chylomicron remnants and HDL-E were bound with the highest affinity. The results, obtained from competitive binding experiments, are consistent with the existence of two distinct receptors on Hep G2 cells: (a) a remnant receptor capable of high-affinity binding of triglyceride-rich lipoproteins and HDL-E, but not of Apo E free LDL, and (b) a LDL receptor capable of high-affinity binding of LDL, NTG-VLDL, and HDL-E. Specific binding of Apo E-free LDL was completely abolished in the presence of 3 mM EDTA, indicating that binding to the LDL receptor is calcium dependent. Specific binding of chylomicron remnants was not inhibited by the presence of even 10 mM EDTA. Preincubation of the Hep G2 cells in lipoprotein-containing medium resulted in complete suppression of LDL receptors but did not affect the remnant receptors. Hep G2 cells seem to be a suitable model for the study of hepatic receptors for lipoprotein in man.
Radionuclide assessment of nitroglycerin influence on abnormal left ventricular segmental contraction in patients with coronary heart disease.
Authors: A F Salel, D S Berman, G L DeNardo, D T Mason
Journal: Circulation (1976)

Noninvasive gated cardiac blood pool imaging with technetium-99m autologous erythrocytes was employed to differentiate reversible verus irreversible abnormal ventricular segmental contraction by regional wall and pump responses to sublingual nitroglycerin in 25 patients with chronic coronary heart disease. In 12 patients without ECG infarctions compared to 13 with infarctions, radioisotopic images demonstrated significantly greater percent decreases in end-systolic volumes (33.8 +/- 6.7 SEM vs 187 +/- 4.4; P less than 0.05) without differences in percent reductions in end-diastolicvolumes (13.7 +/- 3.9 vs 11.6 +/- 6.1; NS) and thereby significantly greater percent increases in ejection fractions (9.3 +/- 1.6 vs 4.1 +/- 2.0; P less than 0.05). In the 22 patients with regional dyssynergy, improvement in disordered pattern and extent of localized dyssynergy following antianginal action of nitroglycerin was related to ECG absence of prior infarction. These obsevations demonstrate the clinical accuracy of atraumatic scintigraphy in the detection of reversible localized dyssynergy due to myocardial ischemia in coronary heart disease.
Gut Microbes and Malnutrition
Authors: M. J. Friedrich
Journal: JAMA (2013)

Dysfunctional gut bacteria combined with a poor diet contribute to the development of kwashiorkor, suggesting that nutrition alone will not wipe out this acute form of malnutrition, according to a study from the United States and Malawi (Smith MI et al. Science. 2012;339[6119]:548-554).
Case 1-1983
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, C. Ronald Kahn, David L. Gang
Journal: New England Journal of Medicine (1983)

Presentation of CaseA 37-year-old woman was admitted to the hospital because of hypoglycemic episodes.There was a long history of psychiatric problems, with multiple admissions to mental hospitals because of suicidal behavior, assaultiveness, and paranoid ideas. Thirteen years before admission she came to this hospital, where she was followed in the psychiatric clinic with a diagnosis of chronic schizophrenia. Various medications were prescribed, including thioridazine, chlorpromazine, fluphenazine hydrochloride, trifluoperazine hydrochloride, and imipramine hydrochloride. Three and a half years before entry she reported consuming up to 180 ml of vodka daily for relaxation. The urea nitrogen was 12 mg per . . .
Risk Factors for Ectopic Pregnancy-Reply
Authors: John F. Annegers
Journal: JAMA (1988)

<h3>In Reply.—</h3> The comments by Drs Weiss and Daling give us an opportunity to elaborate on the interpretation of our study findings. There are two distinct research issues concerning the association between ectopic pregnancy and current IUD use: (1) the relative risk of ectopic implantation given that conception has occurred and (2) the relative risk of conception followed by ectopic implantation. The second relative risk is intrinsically tied to the relative risk of conception itself, while the first relative risk is not. Different control groups are required to assess these separate but related associations. We agree with Drs Weiss and Daling that a nonpregnant control group is required to evaluate the relative risk of conception followed by ectopic implantation. However, our study was not designed to assess this issue. Rather, our study was designed to assess the relative risk of ectopic implantation given that conception has occurred. To evaluate the
An automated system for blood pressure determination during exercise.
Authors: S P Glasser, M R Ramsey
Journal: Circulation (1981)

Automation of blood pressure (BP) measurements during exercise has proved difficult because motion artifact is a major limitation in ultrasound techniques and noise artifact limits the application of sound transduction via microphone pickups. We assessed the value of a new automated system of indirect BP determination by comparing it with manually determined BP in 50 consecutive patients referred for treadmill testing. Automated BP determinations were blinded to the physician or technician who was simultaneously manually auscultating BP. The automated system uses acoustic transduction, but with ECG assist and microprocessing of nonsynchronous noise to overcome the limitations of other systems. The data were statistically analyzed and the correlation coefficient, mean difference and standard deviation of the difference for systolic and diastolic BP for differing levels of heart rate and treadmill stage were determined. The correlation between automated and manually determined BP was 0.964 for systolic BP and 0.848 for diastolic BP. Despite some limitations, this automated system offers significant advantages for exercise BP determination.
Evaluation of Intraductal Ultrasonography in the Diagnosis of Pancreatic Cancer
Authors: T. Furukawa, Y. Tsukamoto, Y. Naitoh, Y. Hirooka, T. Katoh
Journal: Endoscopy (1993)

An intraductal ultrasound (IDUS) probe which is inserted via the papilla into the main pancreatic duct (MPD) was evaluated in the diagnosis of 20 patients with pancreatic cancer. The examination was successfully performed with the probe in 17 of the patients (85%). Due to its high frequency (30 MHz) the probe only allowed visualization of the ductal wall and the immediate periductal vicinity (up to about 10 mm). In 15 of the 20 patients the tumors were surgically resected and IDUS scanning was also performed in vitro on the resection specimens, the results being compared to those of histopathological examination. Of these 15 patients, 13 were found to have ductal adenocarcinomas and all but one had been unequivocally diagnosed as having such by ultrasonography (US), computed tomography (CT), endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography (EUS). IDUS showed an echorich area (corresponding to cancerous canaliculi on histopathological examination), surrounded by an echopoor area (abundant stroma). This pattern was classified as type I. In two patients with intraductal papillary carcinomas in whom a conclusive diagnosis was not established on US, CT, EUS or ERCP, IDUS showed tumorous tissue with an inhomogeneous echopattern outside (type II) or within (type III) the duct. These results show that IDUS offers valuable diagnostic information complementary to ERCP especially in cases of intraductal papillary tumors. Whether the high resolution imaging of the duct and the paraductal tissue can be used to differentiate between the different forms of pancreatic lesions (inflammation, neoplasms) has to be investigated further.
Lupus Erythematosus and Brain Scanning
Authors: GRAEME STEWART
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 November 1975Lupus Erythematosus and Brain ScanningGRAEME STEWART, M.B., M.R.A.C.P., ANTONY BASTEN, M.B., M.R.C.P.GRAEME STEWART, M.B., M.R.A.C.P.Search for more papers by this author, ANTONY BASTEN, M.B., M.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-733 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We were concerned to read the paper in the December 1974 issue on the interpretation of a positive brain scan in patients with systemic lupus erythematosus and localising neurologic signs (1). While not disputing that the patients described may have had cerebral vasculitis, we believe that opportunistic infection of the central nervous system is an equally likely cause of this clinical feature when such patients are receiving immunosuppressive therapy. This is exemplified by three cases, (two with cerebral toxoplasmosis, one with brain abscesses due to nocardial infection) described below and shown in Figure 1. We believe that...References1. BENNAHUM D, MESSNER R, and SHOOP J: Brain scan findings in central nervous system involvement by lupus erythematosus. Ann Intern Med 81:763-765, 1974 LinkGoogle Scholar2. KRAAG G, RICHARDS A, and GORDON D: Brain scanning in lupus erythematosus. Ann Intern Med 82:594, 1975 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GRAEME STEWART, M.B., M.R.A.C.P.; ANTONY BASTEN, M.B., M.R.C.P.Affiliations: Department of Clinical Immunology Royal Prince Alfred Hospital Camperdonn, N.S.W. 2050 Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTreatment of Nocardial Brain Abscess in a Patient With Systemic Lupus Erythematosus and Idiopathic Thrombocytopenic Purpura: Case Report and a Review of the LiteratureNocardiosis in systemic lupus erythematosusCerebral ArteritisPsychiatric Manifestations of Systemic Lupus Erythematosus in Children and AdolescentsNeurological complications of connective tissue and other “collagen-vascular” diseases 1 November 1975Volume 83, Issue 5 Page: 733-734 Keywords Abscesses Brain Central nervous system Immunosuppressives Lupus erythematosus Opportunistic infections Toxoplasmosis Vasculitis ePublished: 1 December 2008 Issue Published: 1 November 1975 PDF downloadLoading ...
The study of anthropometric sizes and physical fitness factors of boy students aged 12-14 in Shahrood city
Authors: Ali Fahiminezhad
Journal: British Journal of Sports Medicine (2010)

The aim of this study was to study of anthropometric sizes and physical fitness factors of boy students aged 12–14 in Shahrood City. This cross-sectional study was performed on 368 boy students aged 12–14 years in Shahrood (2010). Subjects were selected via random sampling. Anthropometric measurements included: height, weight, sitting height, arms span, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), and percentage body fat (BF%) and physical fitness components included: cardiorespiratory fitness (20-m shuttle run test), general strength (dynamometer back and leg), leg power (vertical jump test), flexibility (sit and reach test) and agility (Illinois test). The mean of height (cm), weight (kg), sitting height (cm), arms span (cm), BMI (h/w 2 ), WC (cm), WHR and BF% subjects were 154.1, 43.4, 77.1, 155, 18, 67.6, 84 and 22, respectively. The mean of VO 2 max (ml/kg/min), general strength (kg), leg power (kg/m), flexibility (cm) and agility (s) were 49.6, 92.1, 56.9, 30.5 and 18.97, respectively. There was significant negative correlation between VO 2 max and anthropometric measurements, agility with height, flexibility and leg power, while a significant positive correlation was found between general strength and leg power with anthropometric measurements subjects. Survey results showed that 12–14-year-old boy students in shahrood were of thought height, weight, BMI, general strength and leg power lower from adolescents of other countries and height, weight, BMI almost equal and general strength and leg power higher from adolescents of our country. Also 12–14-year-old adolescent boys in shahrood on base BMI 30.5%, BF% 26.9%, WHR 16.8% and VO 2 max 10% may provide insight into the prediction of future risk chronic disease.
OPTIMAL PERI-INFARCT AND CORE INFARCT THRESHOLDS FOR THE ASSESSMENT OF MORTALITY RISK IN PATIENTS WITH SEVERE ISCHEMIC CARDIOMYOPATHY
Authors: Monique Robinson, Sharif Sabe, Justine Ly, Zoran Popovic, Scott Flamm, Deborah Kwon
Journal: Journal of the American College of Cardiology (2014)
Predisposing Factors in Sudden Cardiac Death in Tecumseh, Michigan
Authors: BENJAMIN N. CHIANG, LAWRENCE V. PERLMAN, MARY FULTON, LEON D. OSTRANDER, FREDERICK H. EPSTEIN
Journal: Circulation (1970)

In an epidemiologic study of the total population of Tecumseh, Michigan, 98 deaths from coronary heart disease were observed between 1959 and 1965. Forty-five of the fatalities occurred within 1 hour of the onset of symptoms and were classified as sudden. The proportion of sudden deaths among men was nearly twice that among women, and the incidence increased progressively with age in both sexes. Hypertensive heart disease, coronary heart disease, or diabetes mellitus had been detected on prior examination in 62% of those who died suddenly. Physiologic abnormalities associated with a high risk of coronary heart disease were also found more frequently than in the total Tecumseh population. All but seven of the persons who died suddenly had abnormalities including arrhythmias and conduction defects which were detected in the standard 12-lead electrocardiogram. Although sudden deaths often seem to occur without warning, the victims are predisposed by conditions which are detectable long before the catastrophic event. The identification of conditions which are precursors of sudden death from coronary heart disease permits a rational consideration of possible preventive measures.
Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data
Authors: E. A. Joura, S. M. Garland, J. Paavonen, D. G. Ferris, G. Perez, K. A. Ault, W. K. Huh, H. L. Sings, M. K. James, R. M. Haupt
Journal: BMJ (2012)

To determine the effect of human papillomavirus (HPV) quadrivalent vaccine on the risk of developing subsequent disease after an excisional procedure for cervical intraepithelial neoplasia or diagnosis of genital warts, vulvar intraepithelial neoplasia, or vaginal intraepithelial neoplasia.
Corrigendum to “Stress Proteins and Cytokines are Urinary Biomarkers for Diagnosis and Staging of Bladder Cancer” [Eur Urol 2011;59:113–9]
Authors: David Margel, Meirav Pevsner-Fischer, Jack Baniel, Ofer Yossepowitch, Irun R. Cohen
Journal: European Urology (2010)
Interpreting inflammatory changes in cervical smears.
Authors: B N Mali, J V Joshi
Journal: BMJ (1993)

issues which may emerge when a statutory service and a voluntary organisation work together.These issues were debated and a set of guidelines were established for all staff involved in the project.The service provision for adolescents with substance misuse problems could progress by the establishment of formal links between the adult substance misuse and child adolescent psychiatry services, the development of training programmes for staff interested in working in this area, a willingness to work alongside voluntary agencies, and clarification of the issues relating to assessment and treatment ofyoung people under 16.
Communicating With Seriously Ill Patients
Authors: Steven Z. Pantilat
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The augmented histamine test in the differential diagnosis between ulcer and cancer of the stomach
Authors: K. Fischermann, K. H. Koster
Journal: Gut (1962)

The maximum gastric acidity has been studied using the augmented histamine test in patients with gastric ulcer, with ulcers in the body of the stomach, with pre-pyloric ulcers, and in patients with gastric carcinoma. The results have not enabled a clear distinction to be made between simple and malignant ulcers.