tbuckley/cabot-search huggingface dataset:
Subvalvar Pulmonary Obstruction Complicating the Postoperative Course of Balloon Atrial Septostomy in Transposition of the Great Arteries
Authors: MICHAEL TYNAN, IAN CARR, GERALD GRAHAM, R. E. BONHAM CARTER
Journal: Circulation (1969)

The immediate results of balloon atrial septostomy performed on 41 infants with transposition of the great arteries have been presented. There were ten hospital deaths, nine of these occurring in infants with additional cardiac malformations; five of these ten infants had operations for the additional malformations. The results show that an adequate interatrial defect can be created by balloon atrial septostomy, and it is suggested that this technique is of particular value in infants under three months of age. Increasing cyanosis following an initial improvement after septostomy was more frequently associated with subvalvar pulmonary obstruction than with inadequacy of the atrial septal defect. Catheterization of the pulmonary artery and angiocardiography are important in the diagnosis of subvalvar pulmonary obstruction.
High high-density-lipoprotein cholesterol in African children and adults in a population free of coronary heart diseae.
Authors: A R Walker, B F Walker
Journal: BMJ (1978)

The serum concentration of high-density lipoprotein cholesterol and the proportion it constitutes of total serum cholesterol are high in children and low in sufferers from coronary heart disease (CHD). Studies in elderly black Africans in Western Transvaal showed them to be free of CHD. HDL concentrations measured at birth and in groups of 10- to 12-year-olds, 16- to 18-year olds, and 60- to 69-year-olds showed mean values of 0.96, 1.71, 1.58, and 1.94 mmol/l (36, 66, 61, and 65 mg/100 ml) respectively; these concentrations constitued about 56%, 54%, and 45%, and 47%, of total cholesterol. Values thus did not fall from youth to age as they did in whites. Rural South African blacks live on a diet high in fibre and low in animal protein and fat; children are active; and adults remain active even when old. These high values of HDL may well be representative for a population that is active, used to a frugal traditional diet, and free from CHD.
THE EFFECT OF EXTERNAL TEMPERATURE ON THE COURSE OF INFECTIOUS MYXOMATOSIS OF RABBITS
Authors: R. F. Parker, R. L. Thompson
Journal: The Journal of Experimental Medicine (1942)

Rabbits, convalescent from vaccinia and in good general health, were subjected to infection with myxoma during a period of exposure to a high external temperature. It was observed that in proportion as the temperature was elevated, a profound change in the course of the myxoma infection occurred. At the highest temperatures, the disease was held completely in abeyance, and no lesions appeared within 17 days of observation. At lower temperatures, lesions appeared which tended to be circumscribed, and which reached their maximum development within 6 or 8 days after inoculation. Regression then set in and complete healing occurred. There was wide variation in the degree of protection which a given temperature conferred on an individual rabbit as measured by the amount of virus required to cause infection, although for single animals the difference in concentration of virus required to produce consistently positive and consistently negative results was not apparently different from that obtaining in the controls. With the data at hand, it does not appear justifiable to draw final conclusions as to the state of immunity of the animals which survived the modified infection.
Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice.
Authors: M A Duchosal, P J McConahey, C A Robinson, F J Dixon
Journal: The Journal of Experimental Medicine (1990)

To study the role of peripheral blood leukocytes (PBL) in the pathogenesis of human systemic lupus erythematosus (SLE), we transferred PBL from 5 SLE patients into 15 severe combined immunodeficiency (SCID) mice. Such reconstituted mice showed long-term presence of auto-antibodies characteristic of the donor in their sera, as well as human immunoglobulin deposition, and in some cases mouse C3, in the renal glomeruli. SCID mice repopulated with PBLs from normal donors do not develop serologic abnormalities or immunodeposits. It is concluded that human SLE serology and some associated renal changes can be reproduced solely by PBL transferred from afflicted patients, and that SCID-human-SLE mice may serve as an in vivo laboratory model for the study of human SLE.
Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance
Authors: Boxun Lu, Ismael Al-Ramahi, Antonio Valencia, Qiong Wang, Frada Berenshteyn, Haidi Yang, Tatiana Gallego-Flores, Salah Ichcho, Arnaud Lacoste, Marc Hild, Marian DiFiglia, Juan Botas, James Palacino
Journal: Nature Neuroscience (2013)
MEDICAL SHOCK FOLLOWING THE USE OF NEOARSPHENAMINE.
Authors: HAROLD ORR
Journal: British Journal of Dermatology (1933)

Journal Article MEDICAL SHOCK FOLLOWING THE USE OF NEOARSPHENAMINE. Get access HAROLD ORR, O.B.E., M.D., D.P.H., F.R.C.P.(C.). HAROLD ORR, O.B.E., M.D., D.P.H., F.R.C.P.(C.). Clinical Professor of Dermatology, University of Alberta, Edmonton, Canada Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 2, 1 February 1933, Pages 58–62, https://doi.org/10.1111/j.1365-2133.1933.tb10141.x Published: 01 February 1933
A high molecular weight form of somatostatin-28 (1-12)-like immunoreactive substance without somatostatin-14 immunoreactivity in the rat pancreas. Evidence that somatostatin-14 synthesis can occur independently of somatostatin-28.
Authors: Y C Patel
Journal: Journal of Clinical Investigation (1983)

Synthesis of somatostatin-14 (S-14) could occur through direct enzymatic processing of precursor somatostatin (prosomatostatin) or via sequential breakdown of prosomatostatin leads to somatostatin-28 (S-28) leads to S-14. If direct processing is important, it should theoretically generate S-14 and a molecule equivalent to prosomatostatin without the S-14 sequence. In an attempt to identify such a molecule, I characterized the molecular forms of S-28(1-12)-like immunoreactivity (S-28(1-12) LI) in the rat pancreas and compared the relative amounts of these forms with those of S-14-like immunoreactivity (S-14 LI). Pancreatic extracts were chromatographed on Sephadex G-50 and Sephadex G-75 columns (Pharmacia Fine Chemicals Inc., Piscataway, NJ) under denaturing conditions and immunoreactivity in the eluting fractions was analyzed by region-specific radioimmunoassays (RIAs). For RIA of S-28(1-12) LI we used a newly developed rabbit antibody R 21 B, 125I-Tyr12 S-28(1-14), and S-28(1-12) standards. This system detects S-28, S-28(1-12), high molecular weight forms of S-28(1-12), but not S-14. S-14 LI was measured using antibody R149, which detects S-14, S-28, and higher molecular weight S-14-like substances, but not S-28(1-12). Three forms of S-28(1-12) LI were identified: Mr 9,000-11,000, Mr 1,200 (corresponding to S-28(1-12), and Mr less than 1,000, comprising, respectively, 35, 53, and 12% of total immunoreactivity. The relative abundance of the 9,000-11,000 mol wt S-28(1-12) LI material was unchanged following removal of S-14 LI from pancreatic extracts by affinity chromatography before gel filtration. Serial dilutions of fractions containing 9-11,000 and 1,200 mol wt materials exhibited parallelism with synthetic S-28(1-12). The total pancreatic concentration of S-28(1-12) LI was 1.56 pmol/mg protein, of which S-28(1-12) accounted for 0.83 pmol/mg protein and 9-11,000 S-28(1-12) LI comprised 0.55 pmol/mg protein. Pancreatic S-14 LI concentration was 2.07 pmol/mg protein, of which 98% corresponded to S-14. S-28-related peaks accounted for <1% of immunoreactivity in both RIAs. I concluded that (a) S-14 is the main form of pancreatic S-14 LI; (b) S-28 is present in very small quantities, in the pancreas; (c) S-28(1-12) LI consist mainly of S-28(1-12) and 9-11,000 mol wt S-28(1-12) LI; (d) 9-11,000 l wt S-28(1-12) LI could represent prosomatostatin without the S-14 sequence; (e) the finding of high concentrations of 9-11,000 mol wt S-28(1-12) LI suggests that S-14 synthesis can occur independently of S-28 and that direct processing of prosomatostatin is an important pathway for S-14 synthesis in the pancreas.
Interventricular Septal Defect
Authors: WELDON J. WALKER, EFRAIN GARCIA-GONZALEZ, ROBERT J. HALL, STEPHEN W. CZARNECKI, ROBERT B. FRANKLIN, SUNIL K. DAS, MELVIN D. CHEITLIN
Journal: Circulation (1965)

Four hundred fifteen patients with interventricular septal defect, proved at cardiac catheterization, have been followed for 1,407 patient years. As a group, they demonstrated marked growth failure in early childhood, which was more striking for weight than height. Ninety patients had serial hemodynamic studies without intervening cardiovascular surgery. Eight demonstrated spontaneous functional closure of their defect; only one progressed to the Eisenmenger syndrome. No patient with initially normal pressure developed pulmonary hypertension. Patients with initial pulmonary hypertension more commonly demonstrated regression than progression of the hypertension. Six patients developed bacterial endocarditis; all recovered. There was a frequent association (11 per cent) between interventricular septal defect and right ventricular outflow obstruction. Some patients developed increasing right ventricular outflow obstruction during the study. Eighteen patients with predominant right-to-left shunt were studied. Seventeen were cyanotic at the time of the initial study. The incidence of cyanosis was equal in the two sexes but females developed it later in life than males. Twenty-nine patients have died. Twenty-two deaths resulted from operative procedures; seven from the natural course of the disease. The principal factors associated with operative mortality was the presence of pulmonary hypertension and surgical repair before age 5. There were no operative deaths in patients with pulmonary artery systolic pressure below 65 mm. Hg. One patient died of progressive pulmonary hypertension 6 years after successful surgical closure of his defect. There is a great need for more information concerning the natural course of this disease in all age groups, both in the unoperated patient and in patients whose defects have been surgically closed.
Safety, Tolerability And Beneficial Immunological Responses Of Complementary Ashmi Therapy To Inhaled Corticosteroids Therapy In Children With Persistent Allergic Asthma With Or Without Allergic Rhinitis
Authors: P.J. Busse, M. Wen, K. Srivastava, C. Wei, G. Li, N. Yu, Y. Liu, S. Wallenstein, J. Wisniversky, C. Qu, H. Sampson, X. Li
Journal: Journal of Allergy and Clinical Immunology (2010)
B-Mode Ultrasonography in Assessment of Thyroid Gland Lesions
Authors: MURRAY MISKIN
Journal: Annals of Internal Medicine (1973)

We have used B-mode ultrasonography in a study of 150 cases to differentiate between cystic and solid characteristics of thyroid nodules, properties that could not be reliably determined by palpation, X ray, or radioisotope scintiscanning. Preoperative ultrasonic diagnosis corresponded to pathological findings at follow-up in 49 of 50 solitary hypofunctioning nodules greater than 1 cm in diameter: 22% were cystic, and 78% were solid. Nine cases of proved thyroid carcinoma were indistinguishable from solid benign lesions. We suggest that solitary cystic thyroid nodules should be treated conservatively by primary needle aspiration, cytologic examination of cyst fluid, and careful follow-up observation while on exogenous thyroid hormone suppression therapy. Patients with solitary solid hypofunctioning nodules are considered to be at greater risk for underlying thyroid malignancy and may be selected for surgical extirpation, depending on other clinical features. Echography, as the initial diagnostic test before scintiscanning, provides useful information and minimizes radiation exposure.
Are Infertile Men Less Healthy than Fertile Men? Results of a Prospective Case-Control Survey
Authors: Andrea Salonia, Rayan Matloob, Andrea Gallina, Firas Abdollah, Antonino Saccà, Alberto Briganti, Nazareno Suardi, Renzo Colombo, Lorenzo Rocchini, Giorgio Guazzoni, Patrizio Rigatti, Francesco Montorsi
Journal: European Urology (2009)
Direet and objective measurement of the area of leg ulcers
Authors: U. Bohler, A. Lentner, W. Jansen, I. Genzel, V. Wienert
Journal: British Journal of Dermatology (1993)

Journal Article Direet and objective measurement of the area of leg ulcers Get access U. Böhler, U. Böhler Department of Dermatology, University of Aachen, W‐5100 Aachen, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Lentner, A. Lentner Department of Dermatology, University of Aachen, W‐5100 Aachen, Germany Search for other works by this author on: Oxford Academic Google Scholar W. Jansen, W. Jansen Department of Dermatology, University of Aachen, W‐5100 Aachen, Germany Search for other works by this author on: Oxford Academic Google Scholar I. Genzel, I. Genzel Department of Dermatology, University of Aachen, W‐5100 Aachen, Germany Search for other works by this author on: Oxford Academic Google Scholar V. Wienert V. Wienert Department of Dermatology, University of Aachen, W‐5100 Aachen, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 128, Issue 2, 1 February 1993, Pages 226–227, https://doi.org/10.1111/j.1365-2133.1993.tb15159.x Published: 01 February 1993
Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.
Authors: G Tiao, S Hobler, J J Wang, T A Meyer, F A Luchette, J E Fischer, P O Hasselgren
Journal: Journal of Clinical Investigation (1997)

Previous studies provided evidence that sepsis-induced muscle proteolysis in experimental animals is caused by increased ubiquitin-proteasome-dependent protein breakdown. It is not known if a similar mechanism accounts for muscle proteolysis in patients with sepsis. We determined mRNA levels for ubiquitin and the 20 S proteasome subunit HC3 by Northern blot analysis in muscle tissue from septic (n = 7) and non-septic (n = 11) patients. Plasma and muscle amino acid concentrations and concentrations in urine of 3-methylhistidine (3-MH), creatinine, and cortisol were measured at the time of surgery to assess the catabolic state of the patients. A three- to fourfold increase in mRNA levels for ubiquitin and HC3 was noted in muscle tissue from the septic patients concomitant with increased muscle levels of phenylalanine and 3-MH and reduced levels of glutamine. Total plasma amino acids were decreased by approximately 30% in the septic patients. The 3-MH/creatinine ratio in urine was almost doubled in septic patients. The cortisol levels in urine were higher in septic than in control patients but this difference did not reach statistical significance. The results suggest that sepsis is associated with increased mRNAs of the ubiquitin-proteasome pathway in human skeletal muscle.
Trends in prescriptions of paracetamol for children
Authors: E. Bentley, I. C Mackie
Journal: BMJ (1995)

probably normal, increased vascular reactivity was shown by high resting peripheral vascular resistance and a reduced response in a cold pressor test.Vasoconstriction, induced by cold that led to an increase in cardiac preload and afterload, combined with augmentation of cardiac preload associated with immersion was thought to explain the development of pulmonary oedema.We suggest that the simultaneous occurrence of contributing factors is required for the development of pulmonary haemoptysis and oedema associated with immersion: cold induced vasoconstriction, as previously reported,3 or the combination of exercise and fluid overload as in our cases.
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
Authors: Tanyel Kiziltepe, Teru Hideshima, Kenji Ishitsuka, Enrique M. Ocio, Noopur Raje, Laurence Catley, Chun-Qi Li, Laura J. Trudel, Hiroshi Yasui, Sonia Vallet, Jeffery L. Kutok, Dharminder Chauhan, Constantine S. Mitsiades, Joseph E. Saavedra, Gerald N. Wogan, Larry K. Keefer, Paul J. Shami, Kenneth C. Anderson
Journal: Blood (2007)
Intestinal Coccidiosis in a Patient with Alpha-chain Disease
Authors: K. Henry, R. G. Bird, W. F. Doe
Journal: BMJ (1974)

During an ultrastructural study of small-intestinal mucosa from a patient suffering from alpha-chain disease organisms were identified within the epithelial cytoplasm which showed the fine structural features of the coccidian group. Though coccidiosis is well recognized as causing a diarrhoeal and often lethal illness in animals it has been neglected as a cause of disease in man. Thus this finding may be significant and warrants further investigation into its possible role in the pathogenesis of alpha-chain disease.
Maspin Expression Is Transactivated by p63 and Is Critical for the Modulation of Lung Cancer Progression
Authors: Sejin Kim, Joungho Han, Jhingook Kim, Chaehwa Park
Journal: Cancer Research (2004)

Abstract Maspin inhibits metastasis of some cancer cells, and clinical studies have identified correlations between maspin loss and poor prognosis in several cancer types. Maspin was found to be significantly overexpressed in lung cancer samples as compared with matched normal lung tissues. However, the regulatory mechanism of maspin expression remains unclear. We show here that differential expression of maspin in carcinoma-derived lung cancer cells is regulated at the transcriptional level. We found that p63 is a critical factor for the transcription of maspin, which is lost in highly invasive cancer cells such as NCI-H157, NCI-322, and NCI-358. No correlation was found between maspin expression and the previously associated transcription factors, p53, Ets1, and Pdef. Instead, maspin expression was strictly dependent on the presence of p63 in lung cancer tissues (P &amp;lt; 0.001) and in the tested cell lines. Transient expression of p63 transactivated the maspin promoter with remarkable fold changes in cells expressing the TAp63, suggesting that TAp63 might be a novel stimulator of the maspin promoter in lung cancer. We have also demonstrated the binding of p63 protein to a previously identified p53-binding site on the maspin promoter by gel shift and chromatin immunoprecipitation assays. In tumor tissues, maspin expression was associated with lymph node involvement (P = 0.035) and tumor stage (P = 0.063) in all tested cases, except squamous carcinoma. In terms of function, ectopic expression of maspin inhibited cell invasion in squamous carcinoma as well as adenocarcinoma. Taken together, these results define maspin as a new molecular target of p63 that eventually inhibits the invasion of lung cancer.
Abstract P1-11-09: Predictive Response Factors (PRF) in an Open, Non-Randomized, Phase II Study of a Combination of Bevacizumab (BZ) and Sequential Chemotherapy as Preoperative Treatment in Patients with Operable HER-2 Negative Breast Cancer (BC)
Authors: P Sanchez Rovira, J de la Haba, M Fernandez, MA Segui, A Llombart, A Anton, A Sanchez, E. Aranda
Journal: Cancer Research (2010)

Abstract Introduction: Association of BZ to chemotherapy in BC improves time to progression of advanced disease. However limited studies are still available for primary treatment, and PRF are not still clearly determined, above all in HER-2 negative patient subgroup receiving antiangiogenic therapy. Objetives: To determine percentage of pathological Complete Responses (pCR) in patients diagnosed of locally advanced BC who receive neoadjuvant sequential therapy in association with BZ, as well as to determine the PRF and perform differential analysis of treatment resistant genes. Material/Methods: 72 patients were included in ML20382 clinical trial. Treatment was 4 cycles of doxorubicin/cyclophosphamide 60/600 mg/m2 x 21 days, followed by 4 cycles of BZ 15 mg/kg + docetaxel 75 mg/m2 x 21 days. Median age was 46 years. Stage classification was 20.8% IIA, 43.1% IIB, 23.6% IIIA, 8.3% IIIB, 4.2% IIIC. Median tumor size was 4.75 cm. 68.1% showed axillary affectation and 80.6% were hormone-receptor positive. Clinical evaluation was done by mammography and mammary ultrasound and/or NMR. Tumor samples were collected before treatment and after surgery for analysis of VEGF, VEGFR, EGFR, pAKT, pMAPK, pTEN, HIF, IGF and differential analysis of gene expresion. Results: 66 patinets evaluated for histopathological response, resulting in 24. 2% of pCR (CI 95%, 14.5-36.4). Multivariate analysis shows a significant increase of responses in ER-negative patients. Treatment was well tolerated, with haematological toxicity G3-4 for 22% of patients (12.5% of neutropenic fever as most noteworthy toxicities). Most relevant non-haematologycal toxicity was mucositis G3 for 19.4% and hypertension for 1.4%. Preliminary analysis shows VEGFr and KISS1 amplification entail a tendency of a lower pCR rate (8.7% and 6.25% respectively). Conclusions: Addition of BZ in preoperative treatment (AC+D) permits a high pCR rate with an adequate safety profile in a subgroup with a median of T&amp;gt;4cm and predominantly ER+. Definitive results about amplification analysis of KISS1, VEGFR and Angiotensin 1 Rc, RNA and proteonomic expression will be presented. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P1-11-09.
Urine Mutagenicity as a Measure of Exposure to Tar-Reply
Authors: Neal L. Benowitz
Journal: JAMA (1987)

<h3>In Reply.—</h3> At present, no direct assays of human biologic fluids for "tar" exposure from cigarettes are available. Urine mutagenicity was selected as an indirect measure for several reasons: (1) The urine of most cigarette smokers is strongly mutagenic whereas the urine of nonsmokers (or of smokers after 24 to 48 hours of abstinence) is in most cases only weakly mutagenic. (2) The mutagenic components of tobacco smoke are found primarily in the tar rather than the gaseous phase of tobacco smoke.<sup>1</sup>(3) Tobacco smoke condensate (tar) from different brands of cigarettes has approximately the same mutagenic activity per milligram.<sup>2</sup>(4) The urine of a person smoking the same brand of cigarette has approximately the same mutagenicity from day to day.<sup>3</sup>Thus, there is a theoretical basis for assuming proportionality between tar exposure and urine mutagenicity. As we and others have pointed out, there is considerable variability
American Medical Publishers' Association.
Authors: Charles Wood Fassett
Journal: JAMA (1895)

St. Joseph, Mo., Feb. 6, 1895. <h3>To the Editor:</h3> —Please be kind enough to announce in your next issue, the meeting of the American Medical Publishers' Association, which will occur on May 6, 1895, at the Eutaw House, Baltimore, Md. A program of interesting papers is being prepared, and a full attendance of the medical publishers of the United States is desired. Yours very truly, Landon B. Edwards, M.D., President.
NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family
Authors: Erhu Cao, Udupi A. Ramagopal, Alexander Fedorov, Elena Fedorov, Qingrong Yan, Jeffrey W. Lary, James L. Cole, Stanley G. Nathenson, Steven C. Almo
Journal: Immunity (2006)