tbuckley/cabot-search huggingface dataset:
THE EFFECT OF SIX WEEKS TALENT DIAGNOSE SYSTEM (TDS) JUMP TRAINING ON MUSCLE REACTION TIME AFTER SURGICAL RECONSTRUCTION OF THE ACL
Authors: Kim Jin Hong, Oak Jung Sok, Lee Dong Kyu, Kim Byung Roh, Yoo Moon Jib, Seo Joong Bae, Shin Yun-a, Lee Hoseong
Journal: British Journal of Sports Medicine (2013)

Background Neuromuscular training protocols that plyometrics, dynamic balance exercises, agility training, etc, can significantly improve biomechanics and neuromuscular performance and reduce anterior cruciate ligament (ACL) injury risk in athletes. 1 2 Objective The purpose of this study was to investigate the effect of 6weeks TDS Jump training on muscle reaction time after surgical reconstruction of the ACL. Methods Seven patients men 12 to 36 months following reconstructive ACL operation continuously participated TDS Jump training at seven sets of five times (7 sets×5 times=35 jumps), 3 days/week, for 6 weeks. Premotor reaction time (PRT) of vastus medialis (VM), vastus lateralis (VL), hamstring medialis (HM), and hamstring lateralis (HL) were recorded by electromyography through the examination sudden knee eversion stress. Two physical therapists evaluated each subject's performance ability using a talent diagnose system (TDS Jump). Results PRT of all tested muscles were significantly decreased after both three and six weeks of TDS Jump training than at before training (p&lt;.05). Grounding time (TDS Jump) of operated legs was significantly decreased after both three and six weeks of TDS Jump training than at before training (p&lt;.05). Conclusions These results demonstrated in the present that TDS Jump training could improve PRT and grounding time in operated legs. Therefore, suggested that TDS Jump training applying in not only an assessment of the neuromuscular function after reconstructive ACL operation but also training and rehabilitation.
Medicine and Art
Authors: I. M. Braverman
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nuclear Studies in Human Pituitary Glands of Varying Weights
Authors: Sally B. Fand
Journal: JAMA (1967)

The endocrine glands react to demands for increased hormone production by an increase in their functional size and their weight. Thus, the thyroid, the adrenal, and the parathyroid glands are known to enlarge demonstrably in the syndromes associated with their increased hormone production. The pituitary, too, is generally considered to react in this manner, and increased pituitary size has been reported, for example, in primary myxedema and following adrenalectomy for Cushing's syndrome: in both instances there is presumably a compensatory increase in tropic hormone output by the pituitary—thyroid stimulating hormone in the first, adrenocorticotrophic hormone in the second. Evidence of a correlation between decreasing size and reduced hormone output can be seen in steroid-treated patients where a diminution in pituitary size—associated with decreased tropic hormone release—may well be the rule. These examples of reactive changes in pituitary size and weight in the human could be challenged; pituitary size increase in
DO DIABETIC PATIENTS INCUR SAME CARDIOVASCULAR RISK AS NON-DIABETIC PATIENTS WITH CAD? A LARGE POPULATION STUDY FOLLOWING SPECT-MPI
Authors: Saqib A. Gowani, Donna Chelle V. Morales, Alan Ahlberg, Sanjeev Bhavnani, Deborah Katten, Donna Polk, Gary Heller
Journal: Journal of the American College of Cardiology (2012)
Upper Gastrointestinal Hemorrhage
Authors: Lee S. Monroe
Journal: JAMA (1971)

The author has reviewed in 32 chapters the etiology, pathogenesis, diagnosis, and treatment of upper gastrointestinal hemorrhage, documenting his own extensive experience and providing a rich bibliographic coverage. The spectrum of pathologic changes leading to bleeding has been correlated with the clinical manifestations and, where pertinent, the sources of the bleeding have been classified as arterial, venous, capillary, or combinations thereof. Presented in tabular form, the collected statistical information which comprises the meat of the volume originates from a wide variety of sources. In the introduction Dr. Palmer quite properly cautions against a strict comparison of the statistical tables because of the diverse manner in which the information was obtained. The reader will appreciate this variability of clinical reporting after a survey of the material presented. Dr. Palmer has long been preeminent in the early use of endoscopy in what he terms the "vigorous diagnostic approach" to upper gastrointestinal hemorrhage.
p73 and p53 Pathway in Human Breast Cancers
Authors: Cecilia Bozzetti, Rita Nizzoli, Antonino Musolino, Eugenia M. Martella, Pellegrino Crafa, Costanza A. Lagrasta, Roberta Camisa, Antonio Bonati, Paolo Lunghi, Andrea Ardizzoni
Journal: Journal of Clinical Oncology (2007)
Treatment of Phenylketonuria with a Diet Low in Phenylalanine
Authors: L. I. Woolf, R. Griffiths, A. Moncrieff
Journal: BMJ (1955)

Pyridoxine 1Nicotinamide .10Calcium pantothenate.35 Ascorbic acid .50a-Tocopherol.1 Acetomenaphthone .1-5Meso-inositol .0Biotin.0-5 Lactose .q.s. As liquid:Crude liver extract 6 ml.Choline chloride.25 mg.Adexolin ".10 drops TABLE III.-Daily Mineral Intake Potassium chloride (KCI) ..1-5 g.Magnesium sulphate (MgSO4.7H,0)0-324 g.Zinc sulphate (ZnSO .7H 0)0-0017 g.Ferrops sulphate (FO .7H,O)0-069 g.Manganous sulphate (NnSO4.4H,O)0-00111g.Cupric sulphate (CuSOg.5H,0)0-00393 g.Hypophosphorous acid.0-05 ml.Water 11 ml.
Tc-99m HMPAO-Labeled Leukocytes for Hematopoietic Marrow Imaging
Authors: TAMIO ABURANO, KUNIHIKO YOKOYAMA, NORIYUKI SHUKE, SEIGO KINUYA, TERUHIKO TAKAYAMA, TAKATOSHI MICHIGISHI, NORIHISA TONAMI, KINICHI HISADA
Journal: Clinical Nuclear Medicine (1992)

The current study was initiated to define whether Tc-99m leukocyte imaging, compared to In-111 chloride imaging, could provide additional information on the hematopoietic activity of the bone marrow in diffuse hematologic disorders. A total of 11 patients with hematologic disorders were studied both with Tc-99m leukocytes and In-111 chloride. One patient with myelofibrosis showed disparate tracer distribution in the bone marrow between the two; Tc-99m leukocyte uptake in the central marrow was highly decreased, whereas In-111 chloride showed expanded marrow. The disparate results of granuloid hypoplasia and erythroid hyperplasia obtained by bone marrow biopsy and aspiration in this patient were thought to give an explanation for the radionuclide findings. The remaining 10 patients showed similar tracer distribution in the marrow, and the observation of hematopoietic cellularity confirmed by bone marrow biopsy and aspiration correlated well with the radionuclide findings. These results demonstrate that Tc-99m leukocytes may be a potential imaging agent for evaluating hematopoietic activity in the bone marrow, in particular granulopoietic activity.
Protein losing enteropathy due to systemic lupus erythematosus.
Authors: M L Wood, I S Foulds, M A French
Journal: Gut (1984)

We report the case of a 29 year old woman with a protein losing enteropathy caused by systemic lupus erythematosus presenting with periorbital oedema. Only three other cases of protein losing enteropathy due to systemic lupus erythematosus have been described, two of which were thought to be because of a primary enteropathy, although the exact pathogenesis was unknown. We suggest that both the protein losing enteropathy and periorbital oedema in this patient were because of increased capillary permeability to serum albumin, as a result of products of plasma C3 conversion which were present in large amounts. It is also of interest that the antigen/antibody system in this patient was RNP/anti-RNP and that DNA antibodies were not detected. This patient falls into a subset of systemic lupus erythematosus in which anti-DNA antibodies are not present, some of which appear to have a more favourable prognosis.
Continuous erythema multiforme clearing on dapsone
Authors: P. Duhra, C.J. Paul
Journal: British Journal of Dermatology (1988)

Journal Article Continuous erythema multiforme clearing on dapsone Get access P. Duhra, P. Duhra The Skin Hospital George Road, Edgbaston Birmingham 815 iBR, U.K. Search for other works by this author on: Oxford Academic Google Scholar C.J. Paul C.J. Paul The Skin Hospital George Road, Edgbaston Birmingham 815 iBR, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 5, 1 May 1988, Page 731, https://doi.org/10.1111/j.1365-2133.1988.tb02583.x Published: 01 May 1988
Contractile State of the Left Ventricle in Man
Authors: JAMES H. GAULT, JOHN ROSS, EUGENE BRAUNWALD
Journal: Circulation Research (1968)

The contractile state of the left ventricle in man was analyzed by correlating left ventricular (LV) dimensional changes during contraction determined from cineangiograms, with simultaneous measurements of LV pressure. The mechanical characteristics of ventricular contraction were expressed quantitatively by deriving the extent and velocity of circumferential fiber shortening at the midwall and the time course of LV wall tension (stress); the instantaneous relations between tension, velocity, and length were then examined. In 6 patients without LV disease, wall tension became maximal soon after the onset of ejection, then declined rapidly; in 9 patients with LV disease, tension fell only slightly with continued ejection. The extent of shortening of the minor LV circumference was consistently less in patients with LV disease than in those without such disease. Velocity of circumferential fiber shortening throughout contraction ranged from 0.22 to 1.11 circumferences/sec in patients with LV disease and from 1.66 to 2.71 circumferences/sec in patients without LV disease, at comparable levels of wall tension (137 to 467 g/cm 2 , and 175 to 409 g/cm 2 , respectively). The initial rate of change of velocity of the circumferential fibers at the onset of ejection also was less than in the group without LV disease. The velocity of shortening of the contractile elements at maximum wall tension was 0.11 to 0.87 circumferences/sec in patients with LV disease and 1.46 to 2.04 circumferences/sec in patients without LV disease.
Infective endocarditis complicating tricuspid valve disease in the carcinoid syndrome
Authors: D G Menzies, I W Campbell, I R Starkey
Journal: BMJ (1988)

A propos d'une observation. Des lesions des valvules sont une complication tardive de la moitie environ des cas de syndrome carcinoide, mais c'est la premiere fois qu'une endocardite vient s'y ajouter
Systemic Mastocytosis Associated With Presence of Rheumatoid Factor
Authors: Jerome Ritz
Journal: JAMA (1976)

We encountered a case of systemic mast cell disease associated with rheumatoid factor; to our knowledge, this has not been reported in the literature. Rheumatoid arthritis as an unrelated second disease cannot be excluded, but there is support for a relation between joint symptoms, rheumatoid factor, and the mast cell disease.
Lymphangiogenesis and lymph node metastasis in breast cancer
Authors: Giles H Cunnick, Wen G Jiang, Tony Douglas-Jones, Gareth Watkins, Kelvin F Gomez, Mike J Morgan, Ashok Subramanian, Kefah Mokbel, Robert E Mansel
Journal: Molecular Cancer (2008)

There have been few studies on lymphangiogenesis in the past due to the lack of specific lymphatic endothelial markers, and lymphatic-specific growth factors. Recently, these limitations have been relieved by the discovery of a small number of potential lymphatic-specific markers. The relationship between lymphangiogenesis and regional or distant metastasis has not previously been investigated in humans. Using these lymphatic markers, it is possible to explore the relationship between lymphangiogenesis and tumour metastasis. This study indirectly quantified lymphangiogenesis by measuring mRNA expression of all seven lymphatic markers described above in breast cancers and correlated these markers with lymphatic involvement and survival. The cDNA from 153 frozen archived breast samples were analysed with Q-PCR for all seven lymphangiogenic markers. This was correlated with various prognostic factors as well as patient survival.There was significantly greater expression of all 7 markers in malignant compared to benign breast tissue. In addition, there was greater expression in lymph node positive/grade 3 tumours when compared to lymph node negative/grade 1 tumours. In 5 of the markers, there was a greater expression in poor NPI prognostic tumours when compared to favourable prognostic tumours which was not statistically significant. There was no association between recurrence risk and lymphangiogenic marker expression.In summary, the findings from this study show that lymphangiogenesis, measured by specific lymphatic marker expression, is higher in breast cancers than in normal breast tissue. Secondly, breast cancers which have metastasised to the regional lymphatics show higher expression compared to those which have not, although the individual differences for all five markers were not statistically significant.
The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein
Authors: Christopher J. Ward, Marie C. Hogan, Sandro Rossetti, Denise Walker, Tam Sneddon, Xiaofang Wang, Vicky Kubly, Julie M. Cunningham, Robert Bacallao, Masahiko Ishibashi, Dawn S. Milliner, Vicente E. Torres, Peter C. Harris
Journal: Nature Genetics (2002)
Bronchoalveolar lavage fluid composition in alveolar proteinosis. Early changes after therapeutic lavage.
Authors: A Alberti, M Luisetti, A Braschi, G Rodi, G Iotti, D Sella, V Poletti, V Benori, A Baritussio
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

In patients with idiopathic alveolar proteinosis, the alveoli are filled with materials rich in surfactant components, especially surfactant protein A (SP-A). The anomaly could be caused by either increased secretion, decreased clearance, or both. To clarify this point, we studied five patients who underwent therapeutic lavage and then were ventilated mechanically for 24 h. During the first 8 h of mechanical ventilation, a surfactant-depleted lung was lavaged at selected intervals, and the bronchoalveolar lavage fluid was analyzed. We observed that, after lavage, various surfactant components accumulated in the airways with different time courses. We also observed that SP-A increased until the second hour and then dropped rapidly, suggesting the existence of an efficient mechanism of removal. These findings suggest that idiopathic alveolar proteinosis might be caused by a primary defect in a slow mechanism of removal or by the presence of factor(s) that interfere with the clearance of surfactant and that can be removed by lavage. It seems clear, however, that an increased secretion rate is unlikely to be the major cause of idiopathic alveolar proteinosis.
Echocardiographic and hemodynamic correlation in transposition of the great arteries.
Authors: S C Park, W H Neches, J R Zuberbuhler, R A Mathews, C C Lenox, F J Fricker
Journal: Circulation (1978)

Echocardiography was performed in 36 patients with transposition of the great arteries (TGA). Twenty patients were studied before a Mustard operation, 14 patients after operation and two patients both before and after operation. Right ventricular end-diastolic dimension (RVED) was larger than normal in each patient and tended to increase postoperatively. In contrast, the left ventricular end-diastolic dimension (LVED) was significantly reduced postoperatively in all patients. A linear relationship was demonstrated between the ratio of LVED/RVED and the ratio of peak systolic pressures in the left and right ventricles in studies both before and after Mustard operation. Systolic anterior motion of the mitral valve was observed in 18% of peroperative patients and increased to 44% postoperatively. The incidence of fluttering of the mitral valve increased from 50% to 94% after the operation. Abnormal septal motion was found in 39% of cases. Abnormal movement of the mitral valve and of the interventricular septum seems to be related to a reversed pressure relationship in the ventricles. Shifting of the ventricular septum toward the left ventricle and consequent distortion of the left ventricular cavity and mitral valve apparatus may be responsible for the abnormal echocardiographic findings. Serial echocardiographic studies may be useful as a noninvasive tool in the assessment of left ventricular pressure or the status of the pulmonary vascular bed in TGA.
Lung infiltrate in a male with a bronchopleural fistula
Authors: C. Raynaud, B. Crestani, M. Grossin, M. Piperaud, M-C. Dombret, M. Aubier
Journal: European Respiratory Journal (2003)

A 49-yr-old male was admitted to the Pulmonology Unit of Bichat Hospital (Paris, France) in February 2001 due to minor haemoptysis.He had a history of right upper lobe tuberculosis in 1970, complicated with secondary aspergilloma in 1999 and treated with itraconazole between April and October 1999.In November 1999, he presented with right pleural empyema (local samples yielded Pseudomonas aeruginosa and Streptococcus sanguis) due to a bronchopleural fistula (fig.1a).Right open thoracostomy was performed in December 1999 and daily local care provided for 14 months until admission.On questioning, he denied experiencing fever, weight loss and shortness of breath.Physical examination results were normal.The pleural cavity was clean and sterile and the bronchopleural fistula still open.Laboratory results, including white blood cell count and erythrocyte sedimentation rate, were normal.The chest radiograph is shown in figure 1b.Computed tomography was also performed (fig.2).Fibreoptic bronchoscopy revealed post-tuberculous scarring in the right bronchial tree.Results of bacteriological and mycological studies were negative, as was the search for Mycobacterium tuberculosis.Bronchoalveolar lavage was performed in the left upper lobe.The resultant fluid was whitish and contained 200,000 cells?mL -1 : 71% macrophages, 21% lymphocytes, 8% neutrophils, and 1% eosinophils.Oil red O stain results are shown in figure 3.
AIB1/SRC-3 Deficiency Affects Insulin-Like Growth Factor I Signaling Pathway and Suppresses <b> <i>v</i> </b>-Ha-<b> <i>ras</i> </b>-induced Breast Cancer Initiation and Progression in Mice
Authors: Shao-Qing Kuang, Lan Liao, Hao Zhang, Adrian V. Lee, Bert W. O’Malley, Jianming Xu
Journal: Cancer Research (2004)

Abstract Although the amplified in breast cancer 1 (AIB1) coactivator is amplified and overexpressed in breast cancers, its role in mammary carcinogenesis remains unknown. We demonstrate that during mammary development and tumorigenesis, the elevation of AIB1 level and its nuclear localization correlate with normal and transformed mammary epithelial proliferation, whereas its lower expression and cytoplasmic localization correlate with mammary epithelial quiescence and differentiation. In this study, the role of AIB1 in breast tumor initiation, progression, and metastasis was studied by generating AIB1+/+, AIB1+/−, and AIB1−/− mice harboring the mouse mammary tumor virus/v-Ha-ras (ras) transgene that induces breast tumors. Breast tumor incidence was reduced dramatically in the intact AIB1−/−-ras virgin mice and inhibited completely in the ovariectomized AIB1−/−-ras mice. Breast tumor latency was delayed significantly in AIB1−/−-ras virgin mice with natural estrous cycles, multiparous mice with cyclically elevated reproductive hormones, and virgin mice bearing pituitary isografts with persistently elevated hormones. Although AIB1 deficiency significantly suppressed mammary tumorigenesis under all of the concentrations of ovarian hormones, it did not affect the promotional role of ovarian hormones on mammary tumorigenesis, suggesting that AIB1 and ovarian hormones contribute to mammary carcinogenesis through different pathways. AIB1 deficiency did not alter the expression of estrogen and progesterone-responsive genes in the mammary gland, but it caused partial resistance to the insulin-like growth factor I because of a significant reduction in the insulin receptor substrates. The impaired insulin-like growth factor I pathway in AIB1−/−-ras mammary epithelium and tumor cells was responsible in part for the suppression of mammary tumorigenesis and metastasis caused by inhibition of cell proliferation and migration. These results suggest that a more effective strategy to control breast cancer is to target AIB1-mediated and ovarian hormone-initiated pathways.
Candidate Gene Association Study of Esophageal Squamous Cell Carcinoma in a High-Risk Region in Iran
Authors: Mohammad R. Akbari, Reza Malekzadeh, Ramin Shakeri, Dariush Nasrollahzadeh, Maryam Foumani, Yulong Sun, Akram Pourshams, Alireza Sadjadi, Elham Jafari, Masoud Sotoudeh, Farin Kamangar, Paolo Boffetta, Sanford M. Dawsey, Parviz Ghadirian, Steven A. Narod
Journal: Cancer Research (2009)

Abstract There is a region with a high risk for esophageal squamous cell carcinoma (ESCC) in the northeast of Iran. Previous studies suggest that hereditary factors play a role in the high incidence of cancer in the region. We selected 22 functional variants (and 130 related tagSNPs) from 15 genes that have been associated previously with the risk of ESCC. We genotyped a primary set of samples from 451 Turkmens (197 cases and 254 controls). Seven of 152 variants were associated with ESCC at the P = 0.05 level; these single nucleotide polymorphisms were then studied in a validation set of 549 cases and 1,119 controls, which included both Turkmens and non-Turkmens. The association observed for a functional variant in ADH1B was confirmed in the validation set, and that of a tagSNP in MGMT, the association was borderline significant in the validation set, after correcting for multiple testing. The other 5 variants that were associated in the primary set were not significantly associated in the validation set. The histidine allele at codon 48 of ADH1B gene was associated with a significantly decreased risk of ESCC in the joint data set (primary and validation set) under a recessive model (odds ratio, 0.41; 95% confidence interval, 0.29-0.76; P = 4 × 10−4). The A allele of the rs7087131 variant of MGMT gene was associated with a decreased risk of ESCC under a dominant model (odds ratio, 0.79; 95% confidence interval, 0.64-0.96; P = 0.02). These results support the hypothesis that genetic predisposition plays a role in the high incidence of ESSC in Iran. [Cancer Res 2009;69(20):7994–8000]