tbuckley/cabot-search huggingface dataset:
Abnormal Lipoprotein Composition in Normolipidemic Diabetic Patients
Authors: Masahide Iwai, Gen Yoshino, Masayuki Matsushita, Munetaka Morita, Kohji Matsuba, Tsutomu Kazumi, Shigeaki Baba
Journal: Diabetes Care (1990)

To see whether there are any lipoprotein abnormalities in diabetic patients without hyperlipidemia, lipoprotein composition was examined in 75 strictly normolipidemic diabetic patients. Their plasma cholesterol (chol) and triglyceride (TG) were limited to less than 6.0 and less than 1.7 mM, respectively. Body-weight- and age-adjusted normolipidemic healthy subjects served as the control group. Plasma total chol and TG and low-density lipoprotein (LDL-) and high-density lipoprotein (HDL-) chol were identical in the diabetic and control subjects. Total apolipoprotein B (apoB) in the plasma of the diabetic subjects was significantly elevated. The chol-apoB ratio in the TG-rich (very-low-density + intermediate-density) lipoprotein fraction (Sf12-400) of the diabetic subjects was significantly higher than the control value, whereas LDL-apoB levels were increased and chol-apoB ratio in the LDL fraction was significantly suppressed in the diabetic subjects. Because each LDL particle contains only one apoB molecule, apoB and chol-apoB ratio in this fraction can represent particle number and chol loading of the LDL particles, respectively. Thus, these data suggest that LDL particle number is increased, and the particles are chol depleted in diabetic subjects even if they are normolipidemic.
Bence Jones proteins and light chains of immunoglobulins. Preferential association of the V lambda VI subgroup of human light chains with amyloidosis AL (lambda).
Authors: A Solomon, B Frangione, E C Franklin
Journal: Journal of Clinical Investigation (1982)

An antiserum prepared against a lambda-Bence Jones protein from a patient (SUT) who had multiple myeloma and amyloidosis had specificity for lambda-light chains of the chemically defined variable (V) region lambda-chain subgroup lambda VI. Sequence analyses of protein SUT and of five other lambda-light chains recognized immunologically as of the V lambda VI subgroup revealed that all six proteins had the N-terminal sequence characteristic for prototype lambda VI proteins. The isotypic nature of the V lambda VI subgroup was demonstrated immunochemically: lambda VI molecules were detected among light chains isolated from the IgG proteins of each of 12 normal individuals and lambda VI antigenic determinants were also detectable on the intact IgG proteins. The frequency of lambda VI molecules among lambda-type light chains is estimated to be approximately 5% based on the finding that 5 of 91 lambda Bence Jones proteins were of the V lambda VI subgroup. Proteins of the V lambda VI subgroup, in contrast to those of the other five chemically-classified lambda chain subgroup, appear to be preferentially associated with the amyloid process as evidenced by the fact that all six lambda VI proteins were obtained from patients with amyloidosis AL and, in addition, 5 of 42 lambda-type monoclonal immunoglobulins from patients with primary or myeloma-associated amyloidosis were classified by immunodiffusion analyses as having lambda VI-type light chains.
Comment on: Bopp et al. Routine Data Sources Challenge International Diabetes Federation Extrapolations of National Diabetes Prevalence in Switzerland. Diabetes Care 2011;34:2387–2389
Authors: Nigel Unwin, Leonor Guariguata, David Whiting, Clara Weil
Journal: Diabetes Care (2012)

We note with interest the approach of Bopp et al. (1) in providing conservative estimates for the prevalence of diabetes in Switzerland and welcome their critical comparison with the 2010 figures from the International Diabetes Federation (IDF) Diabetes Atlas. They show that IDF figures were over twice as high as their estimates.

The authors rightly point out that prevalence data on diabetes from many countries are scarce. In providing national, regional, and global estimates, decisions need to be made on which study or studies are used for a particular country. If a high-quality, up-to-date, nationally representative study in which glucose was measured (either fasting, or better still as part …
Sterility after Vasectomy
Authors: I. Edwards
Journal: BMJ (1973)

We consider that a self-administered questionnaire can be used to detect depression, although a single direct question such as we asked would not be very sensi- tive.However, it is noteworthy that 29 °/, of the replies to the question were positive.There was no excess of positive replies in patients taking methyldopa compared with patients taking other drugs.Patients who became severely depressed on any treatment regimen would have their treatment altered.These patients, however, represent only a stnall proportion of the patients studied.Drs. R. P. Snaith and M. McCoubrie (personal communication) have given the Wakefield Self-Assessment Depression In- ventory to 134 patients receiving me-thyldopa, and have also failed to demonstrate an increase in depression while taking this drug.-Weare, etc.,
Nonclinical Factors and Repeat C-Section
Authors: Gretchen Glesner
Journal: JAMA (1991)

<h3>To the Editor. —</h3> Dr Stafford<sup>1</sup>raises a disturbing question echoed by the media and the public: are private physicians performing an unnecessary number of repeat C-sections simply to line their pockets? While I do not deny the need for some individual and collective soulsearching on this issue, I think there are two important nonclinical factors not addressed by this study that come into play more often than financial incentives. These are fear of litigation and patient preference. In a teaching setting, there is a shared responsibility for patient care and, therefore, far less personal fear of litigation than in the one-to-one relationship of patient and private physician. In the private setting, this leads to overcautious interpretation of fetal monitor tracings, as well as a tendency to "take the easy way out" for patients exhausted from a long and difficult labor. There is a consensus that one can always
Detection of Breast Cancer-Reply
Authors: Jerome A. Urban
Journal: JAMA (1978)

We believe that mammograms should be done routinely on all patients in whom there is some question regarding the presence of carcinoma of the breast. This is done for two reasons: (1) the opposite breast needs to be evaluated because not infrequently second primary breast cancers occur simultaneously or asynchronously and not infrequently these second, less dominant, areas are detected by mammography prior to their clinical detection; (2) at times, the questionable lesion detected by clinical examination does not represent the dominant lesion in that breast, and mammograms may be helpful in directing one to a more accurate biopsy. We do not believe this approach represents overuse of laboratory technology. Minimal early cancers are most difficult to detect, yet when they are detected and treated adequately, they yield a fantastic long-term survival.
P205 Obstructive sleep apnoea screening--cost and clinically effective in a TIA clinic?
Authors: M. Waller, A. Hussey, A. Morris, D. Hargroves, B. Prathibha
Journal: Thorax (2010)

Several large epidemiological studies have shown a strong association between OSA and the development of cerebrovascular disease and there is growing evidence to support this finding. These include Transient Ischaemic attacks and stroke. There is increased morbidity and mortality rates in these patients. Conversely patients with Strokes are at increased risk of developing obstructive and central sleep apnoea. Early recognition and treatment of Obstructive sleep apnoea has been shown to prevent cerebrovascular events. <h3>Aim</h3> To assess the prevalence of cerebrovascular events in a cohort of patients diagnosed with obstructive sleep apnoea in Ashford. <h3>Methods</h3> 100 patients with a confirmed diagnosis of OSA were randomly selected to enter the study. Detailed data, about their demographics, co morbidities as well as sleep, were collected. Obstructive Sleep apnoea was classified as mild, moderate and severe based on AHI (mild &lt;15/h, moderate 15–30/h and severe &gt;30/h). TIA was defined as a neurological deficit which resolved completely within 24 h and was not associated with any changes on CT/MRI. Stroke was classified according to the territory involved and accompanied by CT/MRI changes. Cholesterol was checked in all the patients and associated Diabetes mellitus was noted as well. <h3>Results</h3> In this cohort, more patients had severe sleep apnoea (62%). There was an increased incidence of cerebrovascular morbidities in the severe group as compared with the mild and moderate groups. 20% of all patients had hypercholesterolaemia (45% in the severe group), 10% of all patients had Transient Ischaemic Attack (80% in the severe group), 2% had Stroke (100% in the severe group) and 16% had Diabetes mellitus. <h3>Conclusions</h3> Our study showed significant cerebrovascular comorbidities in patients with obstructive sleep apnoea. There is evidence to suggest that effective treatment of the sleep apnoea improves cerebrovascular outcomes. The fact that most of our patients with cerebrovascular comorbidity had TIA rather than strokes suggest that there is a window of opportunity to prevent further events by effective treatment. This certainly reduces the physical, social and financial burden incurred by strokes. We suggest that all patients with TIA should be screened for Obstructive Sleep apnoea and treated appropriately.
Establishment and Use of a General Practitioner Medical Unit in a District General Hospital
Authors: A. H. Duncan
Journal: BMJ (1972)

An analysis of the establishment and running of a general-practitioner medical unit in a district general hospital has shown that it fulfills a useful and positive role in the area health services and is well used. It shows that selectivity of admission can and does work and that the theoretical drawbacks to such a unit did not materialize in practice during the study.
Malignant Testicular Neoplasms in Infancy
Authors: Adolph Meltzer, Bernard Bloom
Journal: New England Journal of Medicine (1947)

MALIGNANT tumors of the testicle in children are rare. Dargeon,1 reviewing malignant tumors in 1557 children collected from five major sources, found 211 cases involving the genitourinary tract. Matassarin2 quotes Gilbert, who collected 5500 cases of all tumors of the testicle reported in detail from 1803 to 1942 and observed only 131 cases in children under fifteen years of age.There are several reports of testicular neoplasm in children in the early literature.3 , 4 These have been responsible for the frequently quoted opinion that "there have been numerous reports of malignant tumors, usually teratomas in the newborn."5 Wells,6 however, in a . . .
THE PSYCHIATRIC EXAMINATION OF RECRUITS
Authors: ALBERT WARREN STEARNS
Journal: JAMA (1918)

When psychiatric work was begun at a naval training station, a new work was being undertaken. No precedents had been established, and no approved method was in vogue. For this reason the first effort was to seek out and understand the special problem presented. Enough work had been done to show that nervous and mental diseases occur in the Naval Service, and that most of these probably antedate enlistment. An analysis of the reports of the Surgeon-General has been made, and the following facts gleaned from the 1916 report, showing the relation of neurology and psychiatry to the Medical Department for the year 1915:   Total men invalided from the service, 1,272, or 18.68 per thousand.  For nervous and mental diseases, 244, or 3.57 per thousand (by corrected classification, 270, or 21 per cent.).  That is, 19 per cent. of those invalided from the service were for nervous or mental diseases.
Health problems of anaesthetists and their families.
Authors: J Nunn, M Halsey, J Sturrock
Journal: BMJ (1979)

validity because of differences of definition.Internal comparison between the "exposed" and control infants in Dr Tomlin's survey shows no overall significant difference in malformation rates (26 of 277 v 4 of 92, X(2)= 1-72, P-0-2).In summary, Dr Tomlin's survey, while provocative, adds little that is concrete to the existing literature on the possible relationship between exposure to anaesthetic agents and outcome of pregnancy.
Basic tastes as cognitive concepts and taste coding as more than spatial
Authors: Patricia M. Di Lorenzo, Jen-Yung Chen
Journal: Behavioral and Brain Sciences (2008)

Abstract Erickson's treatise intertwines and confuses two major, but separable, issues: whether there are basic tastes and how taste stimuli are encoded. The idea of basic tastes may reflect a natural process of concept formation. By only discussing two spatial coding schemes for taste, Erickson ignores the temporal dimension of taste responses and the contribution of neuronal cooperativity.
Combined effects of elastic band exercise and line dance on health-related fitness
Authors: C K Lim, T U Kim, G H Park
Journal: British Journal of Sports Medicine (2010)

The purpose of this study was to examine the effects of elastic band exercise and line dance on health-related fitness, oestrogen, bone metabolism indicators and immune functions in menopause women. For this purpose, 20 women with the age of 53 years in B City were recruited and they were divided into an exercise group (n=10) and a control group (n=10). Elastic band exercise and line dance were executed with intensity equivalent to 40%-50% heart rate recovery (HRR) during the first period (week 1-4) and exercise equivalent to 50%-60% HRR during the second periods (week 5-12), three times a week, 60 min for 12 weeks. All data were analysed by repeated with analysis of variance for comparison between groups and interaction, and the comparison for within group change was using paired t test, of SPSS V.12.0 program and the α level of p&lt;0.05 was set for all tests of significance. The results of comparative analysis are as follows: the exercise group showed a significant decrease in %fat, but lean body mass was not changed. The interaction effect between group and period according to factors was observed in %fat, muscular endurance, muscular strength, flexibility and cardiovascular endurance, respectively. There was an interaction effect between group and period according to the factor, showing the effect of exercise in oestrogen level, BALP, CD8 and CD19.
A novel neuroprotective therapy for Parkinson’s disease using a viral noncoding RNA that protects mitochondrial Complex I activity
Authors: Wei-Li Kuan, Emma Poole, Michael Fletcher, Sharon Karniely, Pam Tyers, Mark Wills, Roger A. Barker, John H. Sinclair
Journal: The Journal of Experimental Medicine (2011)

Parkinson’s disease (PD) is a neurodegenerative disorder that results in the loss of nigrostriatal dopamine neurons. The etiology of this cell loss is unknown, but it involves abnormalities in mitochondrial function. In this study, we have demonstrated that the administration of a novel noncoding p137 RNA, derived from the human cytomegaloviral β2.7 transcript, can prevent and rescue dopaminergic cell death in vitro and in animal models of PD by protecting mitochondrial Complex I activity. Furthermore, as this p137 RNA is fused to a rabies virus glycoprotein peptide that facilitates delivery of RNA across the blood–brain barrier, such protection can be achieved through a peripheral intravenous administration of this agent after the initiation of a dopaminergic lesion. This approach has major implications for the potential treatment of PD, especially given that this novel agent could have the same protective effect on all diseased neurons affected as part of this disease process, not just the dopaminergic nigrostriatal pathway.
Ventricular Function
Authors: STANLEY J. SARNOFF, ERIK BERGLUND
Journal: Circulation (1954)

Starling's law of the heart has been studied in the dog with a complete circulation with the continuous registration of cardiac output, and atrial and arterial pressures. From this data ventricular function curves were constructed. In any given physiologic state there was a consistent and reproducible correlation between atrial pressure and ventricular stroke work on the same side. The classically conceived descending limb did not occur in the normal heart. The concept of a family of Starling or ventricular function curves adds a third dimension to the adaptive capacity of the heart as put forth by Frank and Starling.
TCT-375 Incidence and History of Coronary Dissections and Plaque Ruptures in ST Elevation Myocardial Infarction assessed by Optical Coherence Tomography
Authors: Mikkel Hougaard, Henrik S. Hansen, Per Thayssen, Anders Junker, Lisbeth Antonsen, Lisette Okkels Jensen
Journal: Journal of the American College of Cardiology (2014)
Skeletal Scintigraphy of Multiple Bone Infarctions
Authors: KIM A. ADCOCK, JOHN C. ROTH
Journal: Clinical Nuclear Medicine (1989)

A series of Tc-99m MDP bone images was obtained of a 57-year-old woman who had chronic myelogenous leukemia with recurrent episodes of bone infarction over a 25-month interval. The Tc-99m MDP Images demonstrate findings consistent with multiple acute and healing phase bone infarctions.
210 EFFECTS OF ALBUMIN ADMINISTRATION IN PATIENTS WITH CIRRHOSIS AND BACTERIAL INFECTIONS OTHER THAN SPONTANEOUS BACTERIAL PERITONITIS. A RANDOMIZED, CONTROLLED STUDY
Authors: A. Nazar, M. Guevara, C. Terra, M. Martín-Llahí, M.E. Baccaro, M. Pavesi, M. Marinelli, E. Urtasun, V. Arroyo, P. Ginès
Journal: Journal of Hepatology (2009)
Abstract 5163: Does melanoma metastasis recapitulate an embryonic neural crest invasion program
Authors: Caleb M. Bailey, Sylvain Ythier, Paul M. Kulesa
Journal: Cancer Research (2010)

Abstract Melanocytes derive from a highly invasive and pluripotent embryonic cell population called the neural crest. It has been proposed that melanocytes might be inherently predisposed to having invasive and metastatic attributes following neoplastic transformation as a result of their embryonic differentiation program. Metastatic melanoma cells are highly invasive and typically exhibit a high degree of plasticity, similar to their neural crest progenitors, but whether these cells recapitulate an embryonic invasion program related to their ancestral neural crest is unclear. We have shown that metastatic melanoma cells transplanted into the chick embryonic neural crest microenvironment invade into the host tissue, migrate along host neural crest cell migratory pathways, do not reform tumors, and can potentially be reprogrammed to a neural-crest-cell-like phenotype (Kulesa et al., 2006; Hendrix et al., 2007; Kasemeier-Kulesa et al., 2008). Here, we use the chick embryo neural crest microenvironment, combined with 2-photon photoactivation cell labeling and time-lapse microscopy, as a model to address the predisposition hypothesis in more detail. We find that melanoma cell orientation to the host cranial neural crest migratory routes and ellipticity of cell shape increase as cells stream out in distinct strand-like structures. Strand-like structures extend into the neural crest microenvironment, but give rise to individually invasive cells away from the neural tube. 2-photon photoactivation of PSCFP2, to discretely label small numbers of melanoma cells in ovo, reveals that the most invasive cells do not start at the tissue transplant periphery but may come from deep within the transplant. In vivo 2-photon time-lapse imaging confirms the unpredictable nature of melanoma dissemination and that some cells are more aggressively predisposed. These results indicate that melanoma metastasis resembles the neural crest migratory pattern but is unpredictable in the spatio-temporal order of invasion. We propose that the chick embryo transplant model is a valid, in vivo model of melanoma metastastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5163.
Cultured human cells with high levels of gold-binding cytosolic metallothionein are not resistant to the growth inhibitory effect of sodium aurothiomalate.
Authors: A Glennas, H E Rugstad
Journal: Annals of the Rheumatic Diseases (1986)

We have previously shown that cells with a high content of the gold-binding protein metallothionein (MT) are resistant to the growth inhibitory effects of gold(III) chloride and auranofin. To investigate whether MT confers resistance to sodium aurothiomalate two cell lines of cultured human epithelial (HE) cells were used; the parental cell line (HE) and a substrain (HE100) containing high levels of cytosolic MT. Sodium aurothiomalate and thiomalic acid without gold both caused a dose-dependent growth inhibition of both cell lines when used in the concentration range 25-300 mumol/l culture medium and for four days9 exposure. MT, despite binding about one third of the cytosolic gold, did not protect against the antiproliferative effect of sodium aurothiomalate. The gold and the thiomalate moieties were distributed differently within the cells; 30% of the cellular gold and 80% of the thiomalate were recovered in the cytosol. Gold was mainly protein bound in both cell lines, as shown by G75 Sephadex gel filtration of the cytosols. In the HE100 cells about 30% of the gold eluted with MT. The thiomalate eluted mainly with substances with molecular weights less than 1000. Cellular synthesis of MT was not observed during sodium aurothiomalate treatment. The results indicate that the sodium aurothiomalate molecule dissociates and support the suggestion that the thiomalate moiety is, in part, responsible for the antiproliferative effect of the drug.
A New Combination Chemotherapy for Resistant Hodgkin Disease
Authors: Vincent Vinciguerra
Journal: JAMA (1977)

A new four-drug combination chemotherapeutic regimen (BVDS) was used in the treatment of advanced Hodgkin disease resistant to MOPP (mechlorethamine hydrochloride, vincristine sulfate, procarbazine hydrochloride, and prednisone). The BVDS regimen, consisting of 12 cycles of bleomycin sulfate, vinblastine sulfate, doxorubicin hydrochloride (Adriamycin), and streptozocin (streptozotocin), was administered to ten patients. Responses were seen in five (50%) of these patients. Complete remissions occurred in three (30%). These results suggest that BVDS is an effective alternative regimen to MOPP, and may be of benefit not only to patients resistant to MOPP, but also to newly-diagnosed patients with advanced Hodgkin disease when combined sequentially with MOPP. (<i>JAMA</i>237:33-35, 1977)
Causes of Transient Cerebral Ischemia
Authors: Richard B. Hunter
Journal: JAMA (1977)

To the Editor.—  In editorially discussing mitral valve prolapse as another cause of cerebral ischemia (236:2783, 1976), transient or otherwise, Hussey mentioned other causes, such as bacterial endocarditis, marantic endocarditis, and mitral valve stenosis complicated by atrial fibrillation. An additional major differential diagnostic consideration was omitted, namely, cerebral embolism originating at variable intervals from a previous left ventricular transmural myocardial infarction (196:133, 1966).