Zomepirac, Interstitial Nephritis, and Renal Failure
Authors: PHILIP J. MEASE
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 September 1982Zomepirac, Interstitial Nephritis, and Renal FailurePHILIP J. MEASE, M.D., ALLAN J. ELLSWORTH, PHARM.D., PAUL D. KILLEN, M.D., ROBERT F. WILLKENS, M.D.PHILIP J. MEASE, M.D.Search for more papers by this author, ALLAN J. ELLSWORTH, PHARM.D.Search for more papers by this author, PAUL D. KILLEN, M.D.Search for more papers by this author, ROBERT F. WILLKENS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-3-454_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report severe renal failure and nephrotic syndrome in three patients taking zomepirac sodium, a nonsteroidal anti-inflammatory drug.A 46-year-old woman who had been taking zomepirac sodium for 2 months for headache developed renal failure and nephrotic syndrome. Laboratory studies showed creatinine, 3.9 mg/dL; blood urea nitrogen, 90 mg/dL; albumin, 1.4 mg/dL; and 24-hour urine protein, 14.5 g. Renal biopsy showed tubular cell vacuolization with sloughing of tubular cells and interstitial edema with a pleomorphic infiltrate. Results of immunofluorescent studies were normal. Zomepirac was withdrawn and prednisone, 60 mg/d, was instituted. Renal failure and nephrotic syndrome resolved...References1. DUNN M and ZAMBRASKI E. Renal effects of drugs that inhibit prostaglandin synthesis. Kidney Int. 1980;18:609-22. CrossrefMedlineGoogle Scholar2. HENRICH W and BLACHLEY W. Acute renal failure with prostaglandin inhibitors. Semin Nephrol. 1981;1:57-60. Google Scholar3. FELLNER S, AFFARAH H, and WOLFE C. Acute renal failure and zomepirac [Letter]. Arch Intern Med. 1981;141:1846. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PHILIP J. MEASE, M.D.; ALLAN J. ELLSWORTH, PHARM.D.; PAUL D. KILLEN, M.D.; ROBERT F. WILLKENS, M.D.Affiliations: University of Washington Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGlomerular, tubular and interstitial nephritis associated with non‐steroidal antiinflammatory drugs. Evidence of a common mechanismPrediction of organ system toxicity with antirheumatic drug therapyAcute Interstitial Nephritis with Glomerulopathy Due to Nonsteroidal Anti-Inflammatory Agents: A Review of Its Clinical Spectrum and Effects of Steroid TherapyIncidence of serious side-effects from non-steroidal anti-inflammatory drugs (NSAIDs) in the USANon-steroidal and Analgesic Therapy in the ElderlyEffects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal functionChemically Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma. Part 2Chemically Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma. Part 1A Zomepirac Reaction Mimicking Ectopic PregnancyAdverse Effects of Nonsteroidal Anti-Inflammatory Drugs on the KidneyAntiinflammatory analgesics and durgs used in rheumatoid arthritis and goutReversible Renal Failure Associated with Ibuprofen: Case Report and Review of the LiteraturePharmacology of nonsteroidal anti-inflammatory drugsAccidents néphrologiques des anti-inflammatoires non stéroïdiensZomepirac Sodium for Primary Dysmenorrhea Syndrome 1 September 1982Volume 97, Issue 3Page: 454-454KeywordsDrugsEdemaHeadachesNephritisProteinsRenal failureResearch laboratoriesSodiumTubular cellsUrine ePublished: 1 December 2008 Issue Published: 1 September 1982 PDF downloadLoading ...