tbuckley/cabot-search huggingface dataset:
Choreoathetosis with Dopamine
Authors: Victoria A. Walker, Maryam Massoumi
Journal: Annals of Internal Medicine (2005)

Letters15 March 2005Choreoathetosis with DopamineVictoria A. Walker, MD and Maryam Massoumi, MDVictoria A. Walker, MDFrom St. Vincent Hospitals and Health Services, Indianapolis, IN 46260.Search for more papers by this author and Maryam Massoumi, MDFrom St. Vincent Hospitals and Health Services, Indianapolis, IN 46260.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-6-200503150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Editor's Note:The lead author of the following Clinical Observation was one of a dozen Associates of the American College of Physicians selected to present a clinical vignette at the 2004 Annual Session in New Orleans. We are proud to present this case report through a special arrangement with the Council of Associates of the College.TO THE EDITOR:Background: Choreoathetosis is an involuntary, short-lasting, continuous, slow, writhing movement of the limbs, trunk, head, face, or tongue. The word derives from the Greek roots chorea, meaning “to dance,” and athetosis, meaning “unfixed.” The differential diagnosis of acute choreoathetosis in adults includes ... Author, Article, and Disclosure InformationAuthors: Victoria A. Walker, MD; Maryam Massoumi, MDAffiliations: From St. Vincent Hospitals and Health Services, Indianapolis, IN 46260. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCurrent awareness: Pharmacoepidemiology and drug safety 15 March 2005Volume 142, Issue 6Page: 478-479KeywordsBlood pressureDopamineHeart rateLevodopaLipidsMovement disordersNeurotransmittersOxygenSyncopeTongue ePublished: 15 March 2005 Issue Published: 15 March 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P12 Alarming ignorance about the dangers of asbestos among UK homeowners
Authors: N. Eiser, I. Jarrold, H. Richardson, K. Huntly
Journal: Thorax (2010)

<h3>Introduction</h3> Nearly 14 million homes were built possibly using asbestos-containing construction materials between 1950 and the mid-1980s. Certain types of asbestos were not banned until 1999. Although exposure to asbestos is the most common cause of death from occupational lung disease, a recent survey clearly demonstrated poor awareness of the dangers of asbestos exposure amongst those trades-people most likely to be exposed to it. Since Do-It-Yourself (DIY) commonly results in asbestos exposure, we wondered whether homeowners are aware of the hazards of asbestos exposure in residential properties. <h3>Methods</h3> A UK-wide, on-line questionnaire survey of homeowners was conducted among the 60 000 users of ‘Opinion Matters’ to elicit their knowledge and views on asbestos between 18.05.2010 and 01.06.2010. <h3>Results</h3> 2002 homeowners completing the questionnaire. 55% live in homes built during the era when asbestos was commonly used as a building material. Respondents were predominantly from older age groups; knowledge about asbestos increased with the homeowner′s age. When buying houses, 40% did not check whether the fabric of the home contained asbestos. 52% respondents had performed DIY in their homes and 23% were planning to do so within the year. While 60% respondents thought that asbestos had been used in residential building and refurbishments, 3% believed that it had never been used and 12% believed that it was present only in factories and warehouse. 41% thought that all asbestos has now been removed from residential buildings. Most respondents (88%) sought professional advice regarding asbestos disposal but 3% just took it to the Council tip, 2% put it into their normal dustbins and 3% didn′t know what to do with it. Some precautions were taken when undertaking DIY; 71% respondents covered the furniture, 50% wore a dust mask and 43% wore protective overalls and goggles. However, only 29% checked for the presence of asbestos-containing materials (Abstract P12 Table 1). <h3>Conclusions</h3> Despite recent Health and Safety Executive awareness campaigns among trades-people, homeowners, including those who practice DIY, have dangerous misconceptions about the presence of asbestos in residential properties and have a poor grasp of essential safety precautions necessary for dealing with it. More effective public awareness campaigns are urgently required.
Selective portal vein embolization with absolute ethanol induces hepatic hypertrophy and makes more extensive hepatectomy possible
Authors: K Ogasawara
Journal: Hepatology (1996)

Portal vein embolization has been used recently to decrease the amount of the liver to be resected and to enhance the function of the remaining hypertrophied lobes. We have observed a strong contact destructivity of absolute ethanol and used it for portal vein embolization. The present study was performed to produce hepatic hypertrophy and to show histopathologic changes that follow ethanol embolization of rat liver. Hepatic proliferation and histopathology were studied in rats receiving low and high doses of absolute ethanol via portal vein and rats undergoing 70% hepatectomy alone. The liver weight of the unresected and unembolized lobes increased rapidly after embolization and hepatectomy. Although the increase was more rapid in the high-dose group than the low-dose group in early days, the final results were not different from each other and were almost equal to those after hepatectomy. Complete obstruction of portal venous branches and massive necrosis were the main histopathologic observations after portal vein embolization with all doses of ethanol. Because the mortality rate in the low-dose group was lower than in the high-dose group and extensive necrosis of the liver parenchyma and subsequent regeneration was sufficient, using minimum dose of ethanol was much safer. Based on the biochemical and hematologic parameters, portal vein embolization with low-dose ethanol did not impair liver function more than hepatectomy alone during the initial 14 days. Portal vein embolization with absolute ethanol makes more extensive hepatectomy possible by reducing the volume necessary to resect and preserves the function of the remaining liver.
Similar IgE Binding to Soybean Proteins from a Genetically Modified Soybean Line, a Near-Isogenic Line and Three Other Non-GM Soybean Lines Using 10 Sera from Soybean Allergic Subjects
Authors: R. Panda, A. Capt, C. Herouet-Guicheney, R.E. Goodman
Journal: Journal of Allergy and Clinical Immunology (2012)
Determinants of survival and the effect of portosystemic shunting in patients with Budd-Chiari syndrome
Authors: Sarwa Darwish Murad, Dominique-Charles Valla, Piet C. de Groen, Guy Zeitoun, Judith A.M. Hopmans, Elizabeth B. Haagsma, Bart van Hoek, Bettina E. Hansen, Frits R. Rosendaal, Harry L.A. Janssen
Journal: Hepatology (2004)

Budd-Chiari syndrome (BCS) is a rare disorder that is characterized by hepatic venous outflow obstruction. The aim of this study was to assess determinants of survival and to evaluate the effect of portosystemic shunting. In this international multicenter study, 237 patients with BCS, diagnosed between 1984 and 2001, were investigated. Univariate, multivariate, and time-dependent Cox regression analyses were performed. Overall survival at 1, 5, and 10 years was 82% (95% CI, 77%-87%), 69% (95% CI, 62%-76%), and 62% (95% CI, 54%-70%), respectively. Encephalopathy, ascites, prothrombin time, and bilirubin were independent determinants of survival. A prognostic classification combining these factors could identify three classes of patients (classes I-III). The 5-year survival rate was 89% (95% CI, 79%-99%) for class I, 74% (95% CI, 65%-83%) for class II, and 42% (95% CI, 28%-56%) for class III. Anticoagulants were administered to 72%; only for patients in class I was this associated with a trend toward improved survival (relative risk [RR], 0.14; 95% CI, 0.02-1.21). Portosystemic shunting was performed in 49% of the patients (n = 117); only for patients in class II, time-dependent analyses suggested an improved survival (RR, 0.63; 95% CI, 0.26-1.49). In conclusion, at the time of diagnosis, patients with BCS can be classified into good (I), intermediate (II), and poor (III) prognostic classes, according to simple baseline clinical and laboratory parameters. Our results suggest an improved survival after surgical portosystemic shunting for patients with an intermediate prognosis (class II). (Hepatology 2004;39:500-508.)
Ancillary Care, Genomics, and the Need and Opportunity for Community-Based Participatory Research
Authors: Kaija Zusevics
Journal: The American Journal of Bioethics (2013)

Click to increase image sizeClick to decrease image size Acknowledgments This work was funded wholly by the Advancing a Healthier Wisconsin Research and Education Program Fund, a component of the Advancing a Healthier Wisconsin endowment at the Medical College of Wisconsin.
COMPARISON OF THE HEMACYTOLOGICAL CONSTITUTION OF MALE AND FEMALE RABBITS
Authors: Paul D. Rosahn, Louise Pearce, Ch'uan-K'uei Hu
Journal: The Journal of Experimental Medicine (1934)

1. The blood cytology of 41 pairs of virgin rabbits was studied, each pair consisting of a buck and a litter mate sister. A comparison of the values for each blood factor of the two groups was made by obtaining the mean difference and the standard error of the mean difference. In addition, correlation coefficients, both zero order and first order eliminating age, and regression equations were calculated for each of the blood cell elements of the bucks and does. 2. It was found that the male values for both the red cell count and the hemoglobin content were higher than the corresponding female values, and these differences were of statistical significance. No differences were observed between the two groups with respect to other cells. Significant positive correlations were obtained between the two sexes for the following blood constituents: Red blood cell count, white blood cell count, hemoglobin content, lymphocytes in both absolute and relative numbers, and neutrophils, basophils, and monocytes in relative numbers. 3. Since all known variables had been held constant, it was concluded that the higher red cell count and hemoglobin value for the male group were the results of constitutional differences between the sexes. Moreover, the significant correlations between the blood cells of male and female litter mates were ascribed to hereditary influences, and thus the female as well as the male rabbit is available for studies on the mechanism involved in the inheritance of the blood formula. In addition, since high correlations were obtained for cells which have been found to be the most reliable indices of the natural immunity of the male host to subsequent inoculation with tumor or syphilis, it was concluded that these cells should give dependable information concerning the natural resistance of the female host to these two diseases.
Abstract 4660: The National Cancer Human Biobank: CaHUB
Authors: Sherilyn J. Sawyer, Kimberly Myers, Dickherber Anthony, Rachel Benkesser, Benjamin Fombonne, David Litwack, Mary Thomas, Nicole Lockhart, Joyce Rogers, Jim Vaught, Carolyn Compton
Journal: Cancer Research (2011)

Abstract The Cancer Human Biobank (caHUB) is the first centralized and public biorepository for human biospecimens in the United States. Established by the National Cancer Institute (NCI) Office of Biorepositories and Biospecimen Research (OBBR), caHUB builds upon the foundation of evidence-based biospecimen resource management practices established by the OBBR Biospecimen Research Network (BRN) and the NCI Best Practices for Biospecimen Resources. The mission of the caHUB is to ensure an adequate and continuous supply of high-quality, highly annotated human biospecimens and provide unique biobanking services for the cancer research community. With a goal of fostering collaboration, communication, education, and the public trust, caHUB will be established as a public-private partnership, working with the broader cancer community, including basic and clinical researchers, advocacy organizations, and pharmaceutical and biotechnology companies. caHUB is a unique centralized biospecimen resource. In response to input from the scientific community, caHUB is focused on providing biospecimens and data collected according to the highest technical and ethical standards, developing biospecimen reference samples that serve as benchmarks for specimen integrity and molecular type, conducting research that supports evidence-based biospecimen best practices, and creating opportunities for collaboration and information exchange across the research enterprise. Through caHUB, the NCI seeks to address the shortage of highly-annotated research biospecimens collected under rigorous standards too costly for private organizations to pursue but required to address difficulties in validation of human biospecimen research results for scientific and regulatory purposes. caHUB is actively seeking the involvement of the cancer research community and supports engagement through three models of collaboration: 1) as customers seeking access to caHUB‘s Biospecimen Collections and Services; 2) as collaborative research partners who require caHUB to assist with specimen collections and analysis; and 3) as partners interested in information exchange with or financial support of this public initiative. For all interested parties, more information is available at http://cahub.cancer.gov. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4660. doi:10.1158/1538-7445.AM2011-4660
Oral Contraceptive Pills and Endometrial Cancer
Authors: LOUISE S. ACHESON
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 November 1979Oral Contraceptive Pills and Endometrial CancerLOUISE S. ACHESON, M.D.LOUISE S. ACHESON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-793_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Horwitz and Feinstein (1) conclude from their epidemiologic study of endometrial cancer that "no association exists between the use of oral contraceptive pills and the subsequent development of endometrial cancer." They correctly point out that a limitation of their data is that only a small number of patients and control subjects had previously used contraceptive pills. Their data may also be limited by the relatively short time from the introduction of contraceptive pills to the present. A typical latent period from exposure to known chemical carcinogens until detection of cancer is 20 to 40 years (2-4). Oral...References1. HORWITZFEINSTEIN RA. Case-control study of oral contraceptive pills and endometrial cancer. Ann Intern Med. 1979;91:226-7. LinkGoogle Scholar2. SELIKOFFHAMMOND IE. Environmental cancer in the year 2000. In: American Cancer Society 7th National Cancer Conference Proceedings. Philadelphia: J.B. Lippincott Co.; 1973:687-96. Google Scholar3. SELIKOFF I. The latent period of occupational cancers. In: LEVINSON C, ed. The New Multinational Health Hazards. Geneva: ICF; 1975:33-40. Google Scholar4. MORRISONCOLE AP. Epidemiology of bladder cancer. Urol Clin North Am. 1976;3:13-29. CrossrefMedlineGoogle Scholar5. HATCHERSTEWARTGUESTFINKLESTEINGODWIN RGFRC. Contraceptive Technology 1976-1977. 8th ed. New York: Halsted Press; 1976:42. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LOUISE S. ACHESON, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1979Volume 91, Issue 5Page: 793-793KeywordsCancer epidemiologyCarcinogensContraceptivesOral contraceptive therapy ePublished: 1 December 2008 Issue Published: 1 November 1979 PDF downloadLoading ...
Mevalonate availability affects human and rat resistance vessel function.
Authors: J B Roullet, H Xue, C M Roullet, W S Fletcher, M J Cipolla, C T Harker, D A McCarron
Journal: Journal of Clinical Investigation (1995)

Previous data in rat conductance vessels indicated that cellular mevalonate contributes to vascular tone and systemic blood pressure control. Using exogenous mevalonate (M) or lovastatin, a 3-hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitor (L), we characterized the role of mevalonate availability in resistance artery function, both in experimental animals and humans. Rat mesenteric artery resistance vessels (MARV, n = 9) were incubated for 48 h with either L, M, L + M, or vehicle (V) and tested for reactivity to NE, serotonin, acetylcholine, atrial natriuretic peptide, and sodium nitroprusside (SNP). Lovastatin increased sensitivity to NE (P < 0.03) and serotonin (P < 0.003), and significantly impaired the response to all three vasodilators. These effects were reversed by co-incubation with mevalonate. Mevalonate alone had no effect. In separate experiments, intravascular free Ca2+ concentration (ivfCa2+) was determined in fura-2AM loaded MARV. Basal ivfCa2+ was increased after a 48-h exposure to L (52.7 +/- 4.6 nM, L, vs. 29.7 +/- 2.4 nM, V, n = 12, P < 0.003), as were ivfCa2+ levels following stimulation with low (100 nM) NE concentrations. Similar ivfCa2+ concentrations were achieved during maximum contraction with NE (10 mM) in both groups. Human resistance arteries of human adipose tissue were also studied. Lovastatin increased the sensitivity to NE (ED50 = 372 +/- 56 nM, V, and 99 +/- 33 nM, L, P < 0.001) and significantly decreased the relaxation to acetylcholine and SNP of human vessels. We conclude that mevalonate availability directly contribute to resistance vessel function and vascular signal transduction systems in both experimental animals and humans. The study calls for the identification of non-sterol, mevalonate-derived vasoactive metabolites, and suggests that disorders of the mevalonate pathway can alter vascular tone and cause hypertension.
SEROLOGICAL STUDIES ON THE BLOOD OF THE PRIMATES
Authors: K. Landsteiner, C. Philip Miller
Journal: The Journal of Experimental Medicine (1925)

The bloods of twenty-one anthropoid apes have been examined serologically. It was found possible to assign each to one of the four human blood groups. The isoagglutinogens of the anthropoids were found to be identical with those of human blood. These very same factors could not be demonstrated in the blood of the lower monkeys. In the blood of the fourteen chimpanzees examined only the isoagglutinogen A has been found, whereas both A and B were present in the blood of the six orangs. The significance of these findings for the knowledge of the human blood groups is discussed.
Constrasts and similarities of acute hemodynamic responses to specific antagonism of angiotensin II ([Sar1, Thr8] A II) and to inhibition of converting enzyme (captopril).
Authors: F M Fouad, J M Ceimo, R C Tarazi, E L Bravo
Journal: Circulation (1980)

The early blood pressure and hemodynamic effects of the converting enzyme inhibitor (CEI), captopril, were compared in 23 hypertensive patients with those of a specific angiotensin II antagonist (AA), [Sar1, Thr8] A II. AA reduced mean arterial pressure (MAP) greater than 10 mm Hg only in seven of 23 patients vs 15 of 23 who responded to CEI (p less than 0.02). With both drugs, changes in MAP were not associated with significant changes in cardiac output (p greater than 0.10 for both drugs), but correlated with changes in systemic resistance (TPR); r = 0.84, p less than 0.001 for AA and r = 0.71, p less than 0.001 for CEI. Changes in TPR and MAP correlated significantly and inversely with log plasma renin activity in both instances; for AA, r = 0.829 and for CEI, r = -0.737; p less than 0.001 for both. The slopes of the two regression lines were not significantly different but the intercepts were +8.47 mm Hg for AA vs -10.17 mm Hg for CEI (p less than 0.001). This quantitative difference in response could be attributed either to an agonistic effect of [Sar1, Thr8] A II or to an additional vasodilator effect of captopril.
Points: Counselling problem drinkers in medical wards
Authors: B. D Hore
Journal: BMJ (1985)

authors in proposing trials of adjunctive chemo- therapy after radical hysterectomy in patients at risk of recurrence but must emphasise that the reported efficacy of drug combinations applies only at present to squamous disease.Alberts et al, using cisplatin, vincristine, mito- mycin, and bleomycin showed significant long term responsiveness of recurrent and metastatic squamous cell carcinoma of the cervix.'Personal experience in their department (AC) and in Ireland using this combination, particularly in unirradiated tissues, confirms these and other reported response rates.A prospective randomised clinical trial is under way under the auspices of the Irish Gynaecological Oncology Group using this combination after radical hysterectomy for stage lb squamous carcinoma of the cervix with associated risk factors for recurrence.This brings us to suggest the hitherto-unthink- able.Given those at high risk of residual disease after radical hysterectomy and the increasingly effective chemotherapy regimens, how do we assess the status of the patient after adjunctive chemotherapy?Are we approaching the concept of secondary exploratory laparotomy subsequent to postoperative chemotherapy for squamous cell carcinoma of the cervix?