tbuckley/cabot-search huggingface dataset:
Bilateral Tibial Adamantinomas Simulating Stress Fractures on Scintigraphy
Authors: Muhammad B. Imran, Saleh A. R. Othman
Journal: Clinical Nuclear Medicine (2011)

A 35-year-old woman presented with continued tenderness in the left leg for more than 2 months. The patient was sent to the nuclear medicine department for evaluation. Three phase blood flow imaging followed by a whole body bone scan were performed. Scintigraphy revealed metabolically active lesions in both tibiae. The lesion was larger in size on left side. Scintigraphy per se raised suspicion of bilateral tibial stress fracture. Slightly increased uptake of tracer in the medial condyle of the right femur was because of old trauma. Evaluation of the whole body bone scan showed another lesion in the left pubic bone. Correlation of the CT scan findings of both tibiae (diaphyseal involvement, areas of lucency, breach of cortex, soft tissue component extending into medullary region) with the whole body bone scan raised the suspicion of adamantinoma, which ultimately proved to be multifocal adamantinomas. Differential diagnosis includes fibrous dysplasia, eosinophilic granuloma, polyostotic osteomyelitis, and skeletal metastatic lesions. (Lädermann et al, Orthopedics. 2008;31:282; Daffner et al, Am J Roentgenol. 1982;139:943–948; Desai et al, J Surg Oncol. 2006;93:429–433; Papagelopoulos et al, Orthopedics. 2007;30:211–215; Siblerstein et al, Diagnostic Patterns in Nuclear Medicine. Reston, VA: Society of Nuclear Medicine; 1998:199–210). This is a rare case of multifocal adamantinomas. This case emphasizes that nuclear medicine physicians should not block their minds to a single entity, and always keep options open. Whenever feasible and possible, the whole body should be scanned. Careful review of the whole set of data and correlation with other imaging modalities helps most of the time to reach a proper diagnosis. Adamantinoma should be included in the gamut/differential diagnosis of tibial stress fractures.
P45 Co-morbidities in Alpha-1-antitrypsin deficiency
Authors: H. Stone, A. Pye, R. A. Stockley
Journal: Thorax (2011)

<h3>Introduction</h3> Chronic obstructive pulmonary disease is well recognised to be a multi system inflammatory condition with systemic manifestations, including co morbidities such as diabetes, ischaemic heart disease and osteoporosis. Patients with alpha-1 antitrypsin deficiency (A1ATD) have a similar spectrum of lung disease and increased levels inflammation and recognised associations with vasculitis and panniculitis. Our aim was to characterise the co morbidities of the UK cohort of patients with A1ATD. <h3>Methods</h3> A retrospective review of the notes of patients with the ZZ phenotype was undertaken for patients who attended the Alpha-1-Antitrypsin Deficiency Assessment and Programme for Treatment (ADAPT) Project in Birmingham, between the years 2001 and 2011. <h3>Results</h3> 764 sets of notes were reviewed. Of the patients included, 75 had died. The most common known co morbidity encountered was hypertension (94 patients, 12.3%), followed by depression (34 patients 4.5%) and osteoporosis (40 patients 5.2%). Interestingly, 10 patients in the cohort had been diagnosed with ulcerative colitis (UC), 4 had proven factor V Leiden deficiency and 25 were hypothyroid. <h3>Conclusion</h3> Depression and osteoporosis are recognised co morbidities in usual COPD, and are among the most common findings in the A1ATD patients, together with hypertension. The figures are lower than reported in usual COPD. There were more patients than expected who had Factor V Leiden deficiency (56 in 12 000 vs 10 in 12 000 of the UK adult population) and 11 potential patients on long-term anticoagulation in whom it was no longer possible to measure factor V Leiden. UC has a prevalence of 3–9 cases per 10 000 in the UK but our figures suggest 130 per 10 000. Finally, thyroid disease is usually more common in women, affecting 15 in 1000 in the UK. In our patient group, the incidence is double (32 in 1000). Overall, the incidence of several inflammatory/autoimmune diseases was higher than predicted for the UK population and a potential link to a coagulopathy was identified.
Police investigate six deaths at Furness General Hospital
Authors: C. Dyer
Journal: BMJ (2012)

A paediatrician has been put on restricted duties pending an internal disciplinary investigation at a crisis hit hospital in the north of England where police are investigating the deaths of at least six patients, including four babies, in an eight month period.

Cumbria Police began their inquiry after a coroner raised concerns about the deaths of four babies and two mothers in 2008 at Furness General Hospital in Barrow-in-Furness, Cumbria.

A spokeswoman for University Hospitals of Morecombe Bay NHS Foundation Trust denied media reports that a paediatrician had been suspended but confirmed that the unnamed doctor was on restricted …
Circulating adrenomedullin is increased in patients with corticotropin-dependent cushing's syndrome due to pituitary adenoma
Authors: Claudio Letizia, Romolo Di Iorio, Giorgio De Toma, Emanuela Marinoni, Sabrina Cerci, Massimiliano Celi, Stefano Subioli, Emilio D'Erasmo
Journal: Metabolism (2000)
Sudden Enlargement of the Neck
Authors: Stephen McDonnell, Matthew Clark
Journal: New England Journal of Medicine (2006)

A 63-year-old man presented with a sudden enlargement of his neck. During the previous 10 years, his neck had grown progressively larger until he was no longer able to button up his shirts or wear a necktie. A previous diagnosis of cystic hygroma had been made, and conservative management advised. The increase in swelling on the left side of his neck occurred suddenly while he was watching television. He felt faint on swallowing and began pooling saliva. On examination, his neck was swollen, soft, and nontender (Panel A). The swelling moved on swallowing. Computed tomography (Panel B) showed a large . . .
Reducing errors in the accident department: a simple method using radiographers.
Authors: L Berman, G de Lacey, E Twomey, B Twomey, T Welch, R Eban
Journal: BMJ (1985)

The assessments by radiographers of 1628 consecutive patients referred for radiography in the casualty department were analysed. The radiographers missed abnormalities in the radiographs in 68 of the cases. Casualty officers missed abnormalities in 63 cases, but only 35 patients were common to both groups. Twenty eight of the radiographs interpreted wrongly by casualty officers were interpreted correctly by radiographers; 16 of these 28 were thought by the accident and emergency consultant to be clinically important. It is suggested that a system whereby radiographers signal abnormalities should be standard practice.
Bone Marrow in the Acquired Immunodeficiency Syndrome
Authors: Robert A. Hromas, J. Lee Murray
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 December 1984Bone Marrow in the Acquired Immunodeficiency SyndromeROBERT A. HROMAS, M.S., M.D., J. LEE MURRAY, M.D.ROBERT A. HROMAS, M.S., M.D.Search for more papers by this author, J. LEE MURRAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-877_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The letter by Franco and associates (1) addresses the poorly understood phenomenon of bone marrow depression in the acquired immunodeficiency syndrome. We recently completed a cytologic and cytokinetic analysis of bone marrow from patients with the syndrome that supports and extends the findings by Franco and associates. Bone marrow biopsy samples from eight homosexual men meeting the Center for Disease Control's criteria for the syndrome were obtained, and differential cell counts and flow cytometry were done. Eleven patients were used as controls, ages 35 to 65, with localized solid tumors without histologic evidence of bone marrow involvement....References1. FRANCOHENDRIXLOKEY CLL: Bone marrow abnormalities in the acquired immunodeficiency syndrome. Ann Intern Med. 1984;101:275-6. LinkGoogle Scholar2. BARLOGIELATREILLEFREIREICH BJE. Characterization of hematologic malignancies in flow cytometry. Blood Cells. 1980;6:719-44. MedlineGoogle Scholar3. GORDONGORDON-SMITH ME. Lymphocytes and haemopoiesis. Br J Haematol. 1981;47:163-9. CrossrefMedlineGoogle Scholar4. AHRONHEIMAUGERJONCASGHIBURIVARDRAABTRAUB GFJFGN. Primary infection by Epstein-Barr virus presenting as aplastic anemia [Letter]. N Engl J Med. 1983;309:313-4. CrossrefMedlineGoogle Scholar5. HASSETTZAROULISGREENBERGSIEGAL JLMF. Bone marrow transplantation in AIDS [Letter]. N Engl J Med. 1983;309:665. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHematological abnormalities in hemophilic patients with human immunodeficiency virus infectionPrevalence of haematological anomalies in asymptomatic HIV infection.Padrão lesional da medula óssea na imunodeficiência adquirida (AIDS)Human Immunodeficiency Virus (HIV) Infection in ChildrenHaematologic manifestations of the human immune deficiency virus (HIV)A comparison of bone marrow findings in patients with acquired immunodeficiency syndrome (aids) and aids related conditions 1 December 1984Volume 101, Issue 6Page: 877-877KeywordsAIDSBiopsyBone marrowBone marrow cellsFlow cytometryHomosexuals Issue Published: 1 December 1984 PDF downloadLoading ...
Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl
Authors: Hisham Abdel-Azim, Yuhua Zhu, Roger Hollis, Xiuli Wang, Shundi Ge, Qian-Lin Hao, Goar Smbatyan, Donald B. Kohn, Michael Rosol, Gay M. Crooks
Journal: Blood (2008)
Abstract 2686: Analysis of cardiac markers on patients receiving 5-fluorouracil, epirubicin, cyclophosphamide with concurrent celecoxib (FEC-C) neoadjuvant therapy for locally advanced breast cancer
Authors: Adrian Y.S Yip, Wings T. Loo, Louis W.C. Chow
Journal: Cancer Research (2010)

Abstract INTRODUCTION/PURPOSE: Anthracycline is widely used and studied in neoadjuvant setting for treatment of locally advanced breast cancer (LABC) for many years. Addition of Cyclooxygenase-2 (COX-2) inhibitors might potentiate the anti-cancer effect of chemotherapy and yet, in consideration of its possible cardiotoxicity, many studies were halted. This sub-study is to evaluate the change in serums level of cardiac troponin I (cTnI), N-Terminal Pro B-Type Natriuretic Peptide (Nt-proBNP) and lactate dehydrogenase (LDH) in LABC patients treated with FEC-C. METHODS: A study group of 34 patients, who received three cycles of neoadjuvant FEC every 3 weeks with concurrent oral celecoxib (F: 500mg/m2; E: 75mg/m2; C: 500mg/m2; Celecoxib: 400mg bid), were included in the cardiac marker analyses. Marker levels of cTnI, Nt-proBNP and LDH in serum samples before treatment and after each cycle of therapy were studied. RESULTS: Patients tolerated well with this regimen. Neither life-threatening toxicity nor clinical symptom of cardiac damage was observed. Across the three time-points of assessments, the mean cTnI did not exceed the upper limit of normal of 0.2 ng/ml, albeit subtle fluctuation in some patients most likely due to anthracycline-based chemotherapy. After 3 cycles of FEC, the mean cTnI was measured 0.06 ng/ml. Nt-proBNP markers did not change significantly during chemotherapy and the means were less than 250 fmol/ml. Serum LDH, a less specific marker, increased from baseline after 3 cycles of FEC-C insignificantly (p = 0.181) while its changes across treatments were within the normal range of 313 – 618 U/L. CONLCUSIONS: Neoadjuvant FEC-C therapy is an active and well tolerated regimen. The short-term use of anthracycline-based chemotherapy with COX-2 inhibitor for LABC before operation incurred some changes on cardiac markers. The change however did not outrange the normal values and indicate any cardiac damage. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2686.
High-speed Ultrahigh Resolution Optical Coherence Tomography before and after Ranibizumab for Age-related Macular Degeneration
Authors: Andre J. Witkin, Laurel N. Vuong, Vivek J. Srinivasan, Iwona Gorczynska, Elias Reichel, Caroline R. Baumal, Adam H. Rogers, Joel S. Schuman, James G. Fujimoto, Jay S. Duker
Journal: Ophthalmology (2009)
The BMJ family
Authors: R. Smith, T. Delamothe
Journal: BMJ (1995)

Some readers will be reading this editorial not in English but in Greek, Hungarian, Polish, Portuguese, Romanian, or Spanish. Indeed, some readers may never have even seen any of the weekly editions of the BMJ published in English from London. This is because the BMJ has 22 editions, several of them published in languages other than English. The aim of all of the editions of the BMJ is to publish rigorous, accessible information that will help doctors improve their practice and influence the international debate on health. But publishing the BMJ in different editions allows us to serve the different needs of different readers.

The BMJ published its first local edition—in India and the Netherlands—in 1985. These local editions are published by local publishers in association with the BMJ Publishing Group, and most of them are monthly. Editors and editorial boards from the country concerned select material from the weekly BMJ that they think will be most …
Military becomes smoke-free work site this week
Authors: P. Gunby
Journal: JAMA (1994)

IF PENTAGON workers consider the building's central courtyard to be one of the Washington, DC, area's more pleasant places to spend a warm-weather lunch hour, military planners of the former Soviet Union apparently viewed it differently—as a prime wartime target for their nuclear weapons. Thus, the courtyard came to be nicknamed (perhaps as the US military's way of thumbing its nose at a potential danger)  Zero.  The Eastern bloc nuclear danger has diminished, but another deadly threat continues to hang over at least some users of the Ground Zero inner courtyard this week. Smoking still will be allowed there (as a designated outdoor tobacco-use area reasonably accessible to workers) when tightened US Department of Defense  rules go into effect Friday.  The department, which is the nation's largest employer with 1.7 million uniformed personnel and some 900 000 civilians on its direct payroll, announced last month that smoking of
MENACE OF THE SLIGHTLY POSITIVE WASSERMANN REACTION
Authors: JAMES HERBERT MITCHELL
Journal: JAMA (1926)

Industrial development in the United States has resulted in a marked degree of standardization of thought and action. Faith in card indexes, "systems" and efficiency methods has been fostered by advertising and by articles on the subject in the popular magazines. The facts and the near-facts of the sciences and particularly of the medical sciences have been set forth in the most sensational manner by writers in the public press. The many new and startling mechanical inventions have given people the impression that the practice of medicine has kept pace with the mechanical development in other fields of endeavor and that diagnoses are now made with mechanical, if not mathematical precision, thanks to the various blood tests. Many laymen believe that not only the presence or absence of disease but the name of the disease as well can be so determined. Such a state of affairs has set the stage
Teaching Occupational Medicine
Authors: NANCY E. GARY
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 March 1983Teaching Occupational MedicineNANCY E. GARY, M.D., G. CRAIG ROSEVEAR, ELIZABETH A. BALINT, M.D.NANCY E. GARY, M.D.Search for more papers by this author, G. CRAIG ROSEVEARSearch for more papers by this author, ELIZABETH A. BALINT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-410_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the editorial by Rosenstock (1) on occupational medicine. The author cites several reasons why residents in primary care specialty program should be trained to treat patients with work-related illness and injury. Various methods were suggested to provide this education, including introduction of a core curriculum, hospital-based clinics, inpatient consultative services, and inclusion of occupational health topics in conferences.We agree that residents in primary care disciplines should be given the opportunity for industrial health experiences. Since 1979 the Department of Medicine of the University of Medicine and Dentistry of New Jersey-Rutgers Medical School...References1. ROSENSTOCK L. Occupational medicine: too long neglected [Editorial]. Ann Intern Med. 1981;95:774-6. LinkGoogle Scholar2. SUSKIND R. Occupational health education: transition and challenge. J Occupat Med. 1978;20:173-8. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Medicine and Dentistry of New Jersey Piscataway, NJ 08854 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1983Volume 98, Issue 3Page: 410-411KeywordsDentistryInpatientsPrevention, policy, and public health Issue Published: 1 March 1983 PDF DownloadLoading ...
Evaluation of low back pain and assessment of lumbar corsets with and without back supports.
Authors: R Million, K H Nilsen, M I Jayson, R D Baker
Journal: Annals of the Rheumatic Diseases (1981)

A method is described for evaluating the progress of patients with back pain. Various symptoms were scored on analogue scales and spinal motion was measured by various techniques. These data were integrated to make subjective and objective indices respectively. Reasonable reproducibility of the measurements was obtained. This technique was used to elucidate the role of the lumbar support in surgical corsets in relief of back pain. Sufferers from back pain were randomly allocated to corsets with and without lumbar supports. There was significant improvement in those with a support compared with those without. On the other hand objective changes measured with the corset removed did not differ between the 2 groups. This study indicates that the spinal support in a lumbosacral corset makes a significant contribution towards the relief of symptoms.
Hospice Effectiveness in Controlling Pain
Authors: Robert L. Kane, Leslie Bernstein, Jeffrey Wales, Rebecca Rothenberg
Journal: JAMA (1985)

Terminal cancer patients were randomly assigned to receive comprehensive hospice care or traditional medical care. Patients were followed up for two years or until death. Pain was measured by the McGill Pain Scale. Frequency and intensity of cancer-related symptoms were also noted. Over the course of the study, 34% of hospice patients and 21% of control patients never reported pain. No significant differences between the two groups could be detected in either the proportion of patients with pain at any time or the intensity of pain. Neither were there differences in the intensity or frequency of cancer-related symptoms. The presence of pain was associated with the presence of other symptoms; a significant correlation was found between the levels of depression and anxiety and pain scores.
Issues Raised in a Group Setting by Patients Recovering from Myocardial Infarction
Authors: CAROLYN BASCOM BILODEAU, THOMAS P. HACKETT
Journal: American Journal of Psychiatry (1971)

The issues that five convalescent male heart patients most frequently raised during 12 weekly group meetings led by a psychiatric nurse concerned group process, current and future states of health, effects of illness on one's life, treatment of illness, the role of patient" and its effect on the family, history of illness, and medical care after discharge. Participants stated that the meetings had significantly influenced their adjustment to and acceptance of myocardial infarction.
Pulmonary edema during IL-2 therapy: combined effect of increased permeability and hydrostatic pressure.
Authors: Y Berthiaume, P Boiteau, G Fick, R Kloiber, G D Sinclair, C Fong, M C Poon, R Lafrenière
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Systemic administration of recombinant interleukin-2 (rIL-2) has been shown to be promising against certain metastatic cancers. However, major side effects, such as pulmonary edema, have limited its widespread use. Although this pulmonary edema has been attributed to a vascular leak syndrome, this hypothesis has not been verified in humans. The purpose of our study was to determine both the severity and mechanism of pulmonary edema in seven patients treated with rIL-2. The severity of edema was assessed by daily evaluation of chest radiographs, using a semiquantitative scale, as well as by repeated measurements of the alveolar-to-arterial oxygen gradient (A-aDO2) in each patient. To determine the mechanism of pulmonary edema, we serially measured in each patient the lung clearance of technetium 99m-diethylenetriamine pentaacetic acid (DTPA) 99mTc-DTPA), the plasma levels of Von Willebrand factor antigen, and the pulmonary capillary wedge pressure (PCWP). Our results show that there was a gradual increase in the chest radiography edema score that was paralleled by a significant increase in A-aDO2 over its baseline value. During rIL-2 treatment, 99mTc-DTPA clearance was augmented, and the plasma concentration of Von Willebrand factor antigen was elevated. PCWP climbed from 7 to 14 mm Hg and serum total protein fell from 66.1 to 42.1 gm/L. The results obtained indicate that although pulmonary edema associated with rIL-2 treatment is partially dependent on increased permeability of the lung, changes in hydrostatic and oncotic forces may be the principal determinants of edema development.
More routine HIV testing is needed to reduce late diagnoses, says public health agency
Authors: M. Limb
Journal: BMJ (2011)

More than half the people who received a diagnosis of HIV in the United Kingdom in 2010 came forward for testing after treatment should have started, latest figures from the Health Protection Agency show.

The figure is a concern, because the later the infection is diagnosed the more likely it is that patients pass on the infection or fall ill, said Valerie Delpech, head of HIV surveillance at the agency. Two thirds of the 680 people who died from HIV in 2010 received a late diagnosis, says the agency in its 2011 report on HIV in the UK. 

Dr Delpech, a consultant epidemiologist, said that HIV was a “manageable” illness for most people in the UK who are …
Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF. Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood. 2009;113(20):5010–5018.
Authors: Thomas D. Nightingale, Krupa Pattni, Alistair N. Hume, Miguel C. Seabra, Daniel F. Cutler
Journal: Blood (2011)