tbuckley/cabot-search huggingface dataset:
Hodgkin's Disease: Premature Report?
Authors: MICHAEL P. CORDER
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 November 1972Hodgkin's Disease: Premature Report?MICHAEL P. CORDERMICHAEL P. CORDERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-5-815 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Moore and associates presented in the July issue (77:1-9, 1972) a progress report on their experience with total-lymphoid irradiation (TNR) alone compared to TNR plus combination chemotherapy with nitrogen mustard, vincristine sulfate, procarbazine hydrochloride, and prednisone (MOPP). In the last paragraph they stated that it is premature to recommend TNR plus MOPP. The thrust of the summary, tables, and discussion, however, relate to the high level of significance of fewer relapses and increased duration of disease-free survival in the TNR plus MOPP group.If one applies the chi-square analysis with Yates' correction to their study groups as...References1. MUSSHOFF K: Prognostic and therapeutic implications of staging in extranodal Hodgkin's disease. Cancer Res 31:1814-1827, 1971 MedlineGoogle Scholar2. JOHNSONGLOVERMARSHALL RMS: Results of radiation therapy and implications for the clinical staging of Hodgkin's disease. Cancer Res 31:1834-1837, 1971 MedlineGoogle Scholar3. CHALMERSBLOCKLEE TJS: Controlled studies in clinical cancer research. N Engl J Med 287:75-78, 1972 CrossrefMedlineGoogle Scholar4. INGELFINGER F : The randomized clinical trial. N Engl J Med Ibid., pp. 100-101 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC USA Hematology-Oncology Service Letterman General Hospital Presidio of San Francisco, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1972Volume 77, Issue 5Page: 815-816KeywordsCombination chemotherapyDisease free survivalHodgkin lymphomaProcarbazineSulfates Issue Published: 1 November 1972 PDF downloadLoading ...
Sodium Morrhuate Delivery to the Lung During Endoscopic Variceal Sclerotherapy
Authors: Alfred F. Connors, Bruce R. Bacon, Stefan D. Miron
Journal: Annals of Internal Medicine (1986)

We determined quantitatively the amount of sodium morrhuate that reaches the pulmonary vascular bed during endoscopic variceal sclerotherapy to ascertain whether this affects the diffusing capacity of the lung to carbon monoxide (DLco). Eleven patients had measurements of DLco and specific diffusing capacity (DLco/VA) before and after sclerotherapy. In ten of these patients sclerotherapy was done using sodium morrhuate mixed with 99mTc-labeled albumin microspheres followed by quantitative radionuclide scanning. Most of the sodium morrhuate, 80 ± 18% (SD) of the total dose, remained in the region of the esophagus. Only 20% of the injected dose reached the pulmonary circulation. There were no changes in DLco or DLco/VA. We conclude that most of the sclerosing solution injected during endoscopic variceal sclerotherapy remains at the site of injection. As a result, the pulmonary endothelium is exposed to small amounts of sodium morrhuate and no change in diffusing capacity occurs.
The relationship between ACL injuries and physical fitness in junior austrian alpine ski racers - a 10 year longitudinal study
Authors: C Raschner, H P Platzer, C Patterson, I Werner, C Hildebrandt
Journal: British Journal of Sports Medicine (2011)

Background Epidemiological studies have shown a high incidence of anterior cruciate ligament (ACL) injuries among competitive alpine skiers. Little is known about modifiable risk factors and there is still equivocal discussion about the gender-related risk factors. Objective To determine the relationship between ACL injuries and internal risk factors among competitive junior alpine skiers. Design Retrospective data analyses of a cohort. Participants 175 female and 195 male competitive alpine ski racers between the ages of 14 and 19. Assessment of risk factors Athletes of the Skigymnasium Stams underwent a test battery three times annually from 1996 to 2006. Norm profiles were established and Z score transformations normalised the different age groups. In the case of an ACL injury the last test result before the injury was compared with the norm values. Main outcome measurements Physical parameters between injured and non-injured athletes. Results Between 1996 and 2006, 57 ACL injuries occurred. The injury rate in females was 2.1 times greater than in males. The binary logistic regression revealed Nagelkerkes R 2 of 0.368 and 0.236 for men and women, respectively. Z scores for relative leg force, ratio of absolute flexion/extension force, relative core strength and reactive strength index were predictive variables for men. Z scores of all these predictive variables except relative leg force were higher (p&lt;0.05) in the non-injured group than in the injured group. Ratio of absolute flexion/extension force and absolute core strength were predictive covariates for women. Z scores for absolute core strength were higher in the non-injured group (p&lt;0.01). Conclusion The risk of injury was higher in females compared with males. Findings suggest that core and leg strength are critical factors for ACL injuries in young ski racers. Targeted evidence-based preventative training programs must include these aspects.
Doctors say no to more independent treatment centres
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

GPs have called on the UK government to stop its programme of establishing independent sector treatment centres. They say the centres have a destabilising effect on NHS hospitals, offer poor value for money, and are unaccountable to local doctors.

Speaking at the annual conference of local medical committees in London last week, Marcus Bicknell, from Nottinghamshire local medical committee, said that as well as the well publicised complaints levelled at treatment centres for working …
Comment on McIntyre. Diagnosing Gestational Diabetes Mellitus: Rationed or Rationally Related to Risk? Diabetes Care 2013;36:2879–2880
Authors: Edmond A. Ryan
Journal: Diabetes Care (2014)

Dr. McIntyre eloquently challenges the National Institutes of Health (NIH) consensus panel conclusions that contradict the American Diabetes Association (ADA) position on the diagnosis of gestational diabetes mellitus (GDM) (1). His claims merit comment.

He feels it is “most disturbing” that the panel did not address the issue of “undiagnosed type 2 diabetes.” While we agree that detecting overt type 2 diabetes early in pregnancy is important, this was not the specific question the NIH panel was charged to answer. McIntyre feels we should embrace change, but “change” and “change for the better” are not synonymous. After a rigorous review, the panel concluded that there was not enough evidence to …
Sunil Kumar Mukherjee
Authors: A. Mukherjee
Journal: BMJ (2015)

Sunil Kumar Mukherjee was a consultant in healthcare of the elderly at Nottingham City Hospital from 1971 to 2004. His colleagues at the hospital praised his dedication, caring nature, and holistic approach to medicine.

Born in Bankura, West Bengal, India, he was the senior class assistant in pathology and qualifiyed with a first class honours degree in pathology. …
George T. Baker III, PhD
Authors: Phil Gunby
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brucellar spondylitis presenting as right hypochondrial pain.
Authors: R W Marshall, A J Hall
Journal: BMJ (1983)

Une observation rare: douleurs du quadrant superieur droit et fievre chez une femme yougoslave de 24 ans. Une scintigraphie au gallium revele une lesion des dernieres vertebres thoraciques, la biopsie montre qu'il s'agit d'une brucellose
Niacin and HDL Cholesterol — Time to Face Facts
Authors: Donald M. Lloyd-Jones
Journal: New England Journal of Medicine (2014)

For the past four decades, the concentration of cholesterol contained in high-density lipoprotein (HDL) particles has been a major focus of research and a target for potential prevention opportunities. Data from observational epidemiologic studies have consistently shown a strong inverse association between HDL cholesterol concentration and the risk of coronary heart disease that is linear and graded, at least through the majority of the HDL cholesterol distribution encountered in the general population.1 But clinical trials have yet to show a causal role for HDL cholesterol or to deliver the longed-for outcome of reducing the risk of coronary heart disease and . . .
Jet Injection of Insulin vs the Syringe-and-Needle Method
Authors: Charles Weller
Journal: JAMA (1966)

Many devices have been developed that would eliminate the need to inject material by needle and syringe. The development of jet injectors was one of the first fundamental improvements made in parenteral administration. Scientists had long ago observed that jets of oil under great pressure could penetrate the skin with little or no pain. Subsequently, it was reasoned that medication could be injected in a similar manner,<sup>1</sup>and this led to the development of jet injectors. Instruments of this type are used throughout the world, and a multiple-dose injector for mass immunization has been extensively used at military installations. Further improvements led to the development of jet injectors which are mechanically simple, compact, easy to operate, and portable. The jet injectors (Hypospray) used in this study were of two types. The first (model A) featured a metal-covered ampule containing 1 cc of the material to be injected. The second
Book Review The Breast: Comprehensive management of benign and malignant diseases Second edition. Edited by Kirby I. Bland and Edward M. Copeland III. 1631 pp. in two volumes, illustrated. Philadelphia, W.B. Saunders, 1998. $225. 0-7216-6656-6
Authors: Joop A. van Dongen
Journal: New England Journal of Medicine (1999)
Anthropology and Medical Education
Authors: Bruce A. Harris
Journal: JAMA (1963)

<h3>To the Editor:—</h3> I cannot resist commenting upon the article by Montagu in the Feb 16 issue ofThe Journal(<b>183</b>:577). Montagu states that medical schools tend to flatten out the student and destroy any tendency that he may have for original thought. On the contrary, my medical school, even 20 years ago, earnestly encouraged all manner of original investigations. Numerous of these original investigations were in fact accomplished by my classmates and contemporaries. I am sure that other schools have a similar program. Next, Montagu said that medicine is dehumanized, and that doctors are unemotional. I suggest that a man goes into medicine because he is an emotional and humane person from the beginning. He is an adult when he reaches medical school, and no amount of medical school training is going to grind humanity out of him. It has been my observation that doctors as a group
Liposomes as vehicle for allergen presentation in the immunotherapy of allergic diseases
Authors: N. Arora, S. V. Gangal
Journal: Allergy (1991)

Liposomes are non-toxic, biodegradable and weakly immunogenic lipid vesicles which can be used as immunomodulating agents. In the present study, multilamellar vesicles (MLV) and small unilamellar vesicles (SUV) were used to incorporate an allergenic protein from Artemisia scoparia pollen. MLV incorporated more allergenic protein than SUV. To assess the immunomodulating effect of allergen entrapped in liposomes, Swiss strain mice (made IgE responders) were injected with either free allergen or liposome-entrapped allergen (LEA) and their immune response was measured in terms of specific IgG and specific IgE levels. Results indicated that specific IgE response was significantly lower in mice injected LEA (P less than 0.02) than in mice injected free allergenic protein. Although specific IgG response was higher in mice injected LEA, there was no statistically significant difference between the two groups. Potential use of liposomes as non-immunogenic biocompatible vehicle for antigen presentation in immunotherapy will be discussed.
Esophageal Obstruction by Water-Insoluble Medication
Authors: Alvin J. Cummins
Journal: JAMA (1966)

<h3>To the Editor:—</h3> All physicians are painfully aware of the potentially hazardous effects of the flood of new drugs being released by the pharmaceutical industry. Most of these dangers lie in toxic pharmacologic action of the drugs or allergic reactions to them. The present report is of a mechanical hazard involved in esophageal obstruction from a relatively new "sustainedaction" form of pentaerythritol tetranitrate ( Peritrate—SA). <h3>Case Report:—</h3> A 62-year-old man, a police guard, was admitted to the hospital because of sudden severe dysphagia of 24 hours' duration. He was unable to swallow solid food, liquids, or saliva and regurgitated them freely and promptly. The severe dysphagia had begun in the morning and he remembered eating a normal meal the night before and also (but only recalled later) taking a "new heart pill" which a physician had recently prescribed for him. Three years previously he had had a subtotal gastrectomy and gastrojejunostomy
Clupea Harengus var. Schmalzica
Authors: Harris C. Faigel
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Drs. Nuessle, Norman, and Miller (<i>JAMA</i><b>192</b>:726-727 [May 24] 1965) observed an untoward reaction in a patient receiving a monamine oxidase inhibitor, who indulged a craving for pickled herring. Pickled Schmaltz herring is sold in four basic preparations: in brine, in cocktail sauce, in wine sauce, and in sour cream sauce. The preparation of the wine and sour cream sauces requires products of fermentation and the question then arises, "Did the tyramine come from the herring or the sauce?" For if the latter were the source of this unwanted reaction, might we not point to the catechism regarding goose and gander?
Branching of cerebellar parallel fibres can assist the convergence of mossy fibre input sequences that are temporally and spatially dispersed
Authors: M. Lidierth
Journal: Behavioral and Brain Sciences (1997)

It is suggested that bifurcation of parallel fibres in the cerebellar cortex assists the spatiotemporal convergence of temporally dispersed and asomatotopic inputs to granule cells. This increases the number of combinations of inputs which can be compared for the purpose of sequence recognition.
Spain decentralises its healthcare system
Authors: X. Bosch
Journal: BMJ (2002)

Spain's state health service became a totally decentralised system at the beginning of this year after the Cabinet approved in December two royal decrees to allow the transfer of health services from central government to the country's regions.

Ten of the 17 regional communities (also called autonomous communities) making up the geographic and political map of Spain will now manage their own public health services. The other seven—Catalonia, the Basque country, Valencia, Galicia, Andalucia, Navarra, …
Laboratory Diagnostic Procedures in the Rheumatic Diseases
Authors: J. W. Hollingsworth
Journal: JAMA (1975)

The second edition of this book on laboratory procedures in rheumatology is indeed welcome. There are 12 chapters, all by eminent and wellqualified experts, and the entire spectrum of the subject is well covered. Dr. Cohen is to be congratulated for his editorial skills and his astute selection of collaborators, because all of the sections are well done and carefully balanced, with little or no overlap. Each section contains a succinct discussion of clinical uses and interpretations of the tests, and then a section on detailed methodology for those who want to establish the test in their laboratory. At the end of each section, a selective but comprehensive bibliography is available for the reader who needs more detailed information. Among the chapters, it is difficult to avoid commenting favorably on each. Dr. Cohen and two of his colleagues from Boston have done a masterful job of reviewing synovial fluid analyses.
Metabolic activation and lung toxicity: a basis for cell-selective pulmonary damage by foreign chemicals.
Authors: M R Boyd
Journal: Environmental Health Perspectives (1984)

The lungs may be exposed to potentially toxic metabolites that are either formed in situ or which are present in the circulation. Therefore, pulmonary injury may be a prominent effect of certain classes of chemicals that undergo bioactivation in the body. The specific types of lung cells damaged may depend upon factors such as preferential exposure or accumulation of parent compounds and/or metabolites, differences in cellular defense mechanisms, or the specific mechanism of activation of the toxicant. Prior knowledge about the metabolism, disposition and mechanism of bioactivation of a particular compound may allow prediction of the type of lung cell damage it is likely to produce. Conversely, morphological observations of characteristic types of cell-specific injury in the lung may suggest a likely biochemical mechanism of toxicity for the particular chemical involved.
Timing of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Patients With Lung Cancer With <i>EGFR</i> Mutations
Authors: Teresa Moran, Lecia V. Sequist
Journal: Journal of Clinical Oncology (2012)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2012.43.1858 Journal of Clinical Oncology - published online before print July 2, 2012 PMID: 22753908 Timing of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Patients With Lung Cancer With EGFR Mutations Teresa MoranxTeresa MoranSearch for articles by this author Lecia V. SequistxLecia V. SequistSearch for articles by this author Show More Catalan Institute of Oncology, Hospital Germans Trias i Pujol and Universitat Autonoma de Barcelona, Barcelona, Spain; Massachusetts General Hospital, Boston, MAMassachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA https://doi.org/10.1200/JCO.2012.43.1858 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
Improving Accessibility to Inpatient Dermatology Through Teledermatology
Authors: Lindy P. Fox
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Familial Azotemia
Authors: Chen H. Hsu, Theodore W. Kurtz, Pablo U. Massari, Sergio A. Ponze, Bruce S. Chang
Journal: New England Journal of Medicine (1978)

We performed detailed studies of renal function in two of five related patients with normal serum creatinine levels to determine the mechanism of their chronic azotemia. Inulin and para-aminohippurate clearances, maximum tubular transport of para-aminohippurate, and renal acidification were within normal limits. In addition, renal concentrating and diluting abilities of these patients were similar to those of four normal controls. Urea clearances of both patients during maximum water diuresis (27.6 and 40.8 ml per minute per 1.73 m2) and antidiuresis (5.3 and 4.0), however, were much lower than mean (± S.E.M.) values in the normal controls (70.4±3.7 and 30.0±3.42 ml per minute per 1.73 m2, respectively). Thus decreased urea excretion despite otherwise normal renal function was responsible for the chronic azotemia of these patients. The genetic defect in renal urea clearance appeared to be inherited as an autosomal dominant trait. (N Engl J Med 298:117–121, 1978)