tbuckley/cabot-search huggingface dataset:
Hypertrophic lupus vulgaris of 67 years' duration
Authors: C. Goicoechea, P. Ruiz-Avila, E. Soler, M.Bustos de Abajo, J. Linares, J. Abad, R. Naranio
Journal: British Journal of Dermatology (1994)

Journal Article Hypertrophic lupus vulgaris of 67 years' duration Get access C. Goicoechea, C. Goicoechea Dermatology Service, University of Granada Hospital, E‐18071 Granada, Spain Search for other works by this author on: Oxford Academic Google Scholar P. Ruiz‐Avila, P. Ruiz‐Avila Dermatology Service, University of Granada Hospital, E‐18071 Granada, Spain Search for other works by this author on: Oxford Academic Google Scholar E. Soler, E. Soler Dermatology Service, University of Granada Hospital, E‐18071 Granada, Spain Search for other works by this author on: Oxford Academic Google Scholar M.Bustos de Abajo, M.Bustos de Abajo Pathology Service, University of Granada Hospital, E‐18071 Granada, Spain Search for other works by this author on: Oxford Academic Google Scholar J. Linares, J. Linares Pathology Service, University of Granada Hospital, E‐18071 Granada, Spain Search for other works by this author on: Oxford Academic Google Scholar J. Abad, J. Abad Dermatology Service, University of Granada Hospital, E‐18071 Granada, Spain Search for other works by this author on: Oxford Academic Google Scholar R. Naranio R. Naranio Dermatology Service, University of Granada Hospital, E‐18071 Granada, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 1, 1 July 1994, Pages 142–143, https://doi.org/10.1111/j.1365-2133.1994.tb08478.x Published: 01 July 1994
Chemotherapy and Conservatism in Acute Suppurative Otitis Media
Authors: J. B. Jessiman
Journal: BMJ (1941)

THlE 13RoTISH 399injected with androsterone and testosterone propionate, in most cases for a prolonged period of two months.A detailed account of these experiments and of the technique employed will be published elsewhere.A preliminary statement is given here of the results obtained in 85 experi- ments on 46 male rats when the potential strength of the heart was measured in these three groups of rats.The measurements were made by attaching 10 and 15 gramme weights to the level pulled by the heart's contractions and tracing these contractions on a kymograph.The ampli- tLude of the contractions was measured on the tracings and their number counted before and during the suspension of the weights, in both cases for a period of one minute.Woodworth's (1903, p. 228) quotient of the potential energy of the heart was used for expressing the results obtained, which have been statistically analysed by one of us (J.Cohen), using the same method as above.These quotients of potential energy of the heart in the three groups of rats were as follows: Before Test During Test Control normal rats .81.3 73.5 Control castrated rats .71.9 60.0 Castrated rats injected with male hormones .78.2 81.7
905-54 Intercenter Agreement in Interpretation of Dobutamine Stress Echocardiograms. A Multicenter Trial
Authors: Rainer Hoffmann, Harald Lethen, Thomas Marwick, Mariarosaria Amese, Paolo Fioretti, Alessandro Pingitore, Eugenio Picano, Thomas Buck, Raimund Erbel, Frank A. Flachskampf
Journal: Journal of the American College of Cardiology (1995)
Activation of MET by Gene Amplification or by Splice Mutations Deleting the Juxtamembrane Domain in Primary Resected Lung Cancers
Authors: Ryoichi Onozato, Takayuki Kosaka, Hiroyuki Kuwano, Yoshitaka Sekido, Yasushi Yatabe, Tetsuya Mitsudomi
Journal: Journal of Thoracic Oncology (2009)
A new face in the line of defense against dementia
Authors: Laurie Goodman
Journal: Journal of Clinical Investigation (2004)

A new face in the line of defense against dementiaIn 1984 an act of Congress directed the NIH, specifically the National Institute on Aging, to establish a number of Alzheimer's Disease Research Centers (ADRCs) that would provide the infrastructure to support and advance research on the disease throughout the United States.Each center would be funded, currently at a total of $6.5 million, for a period of 5 years, after which it would come up for competitive renewal.This year the University of California, San Francisco (UCSF) Memory and Aging Center became the newest ADRC and was the only new institution to be awarded this highly competitive grant in the 2004 funding period.(For the complete list of centers, see http:// www.alzheimers.org/adcdir.htm#tex.)Being named an ADRC brings special advantages to a research institute, because it becomes part of a larger interactive network and takes on a leadership role for the dementia research community.Bruce Miller, the director of the UCSF Memory and Aging Center and principal investigator of the new ADRC, explained what the designation would mean for their community of researchers."I think that the idea of doing things collectively is what's so exciting about these centers," he told the JCI."You become part of an Alzheimer's center network . . .a national group that thinks collectively about these disorders.You participate in the national trials with new and exciting medication.You share certain aspects of the database."The database resources include material from a national genetic bank, which allows centers access to information on rare families that do not have the usual phenotypic or genotypic characteristics of families with dementia.Tissues, DNA samples, and pathology samples are also available to members of the network.Miller felt there were several reasons why the UCSF center was chosen to be an ADRC.He noted that the exceptional basic research that goes on at the university certainly contributed but also thought that another important element was the diversity of its patient populations, especially since this center will be one of the few that will focus not just on Alzheimer disease, but also on other forms of dementia."We see a variety of degenerative dementias," said Miller, "and see many patients with disorders that are considered somewhat unusual, such as the frontotemporal dementias and the prion-related diseases.We do pretty
Instincts of the Herd in Peace and War: 1916-1919
Authors: Harry A. Wilmer
Journal: JAMA (1986)

This seminal book, first published in 1916, has been republished in a handsome limited edition by the British Medical Association because of its present significance. It is a pioneering effort in applied social psychology. It offers insight into the world of today, threatened by the competing herd instincts of different nations, and within it societies gone awry, with actual and potential horrendous consequences. Trotter's idealistic conclusion that reason and disciplined intelligence will bring about peace or resolution of the herd instinct problems of nations is doubtful. Bearing in mind what is now known about the power of the unconscious and the limitations of reason, disciplined rational thought appears as only one step. Since Trotter wrote this book and its addendum in 1919, there have been World War II, with the loss of 55 million lives, and 140 other wars, with more being spawned all the time. Instincts of the Herd
Abstract 5261: Aberrant expression of HDAC6 sustains malignant progression by preventing epidermal growth factor receptor degradation in gastric cancer
Authors: Se Jin Park, Hyun Jin Bae, Jung Woo Eun, Qinngyu Shen, Hyung Seok Kim, Woo Chan Shin, Won Sang Park, Jung Young Lee, Suk Woo Nam
Journal: Cancer Research (2014)

Abstract Cytoplasmic deacetylase, histone deacetylase 6 (HDAC6) is a critical component of the lysomal protein degradation pathways. HDAC6 has been shown to be involved in carcinogenic transformation and to modulate the epithelial-mesenchymal transition in several cancers by way of the regulations of several critical cellular functions, but the biological roles in gastric carcinogenesis remains to be elucidated. In this study, we observed that HDAC6 is aberrantly over-expressed in a subset of gastric cancer, and that targeted-inactivation of HDC6 caused cell cycle and cell death pathways-independent growth inhibition. Additional experiments evidenced that ectopic overexpression of HDAC6 sustains epidermal growth factor receptor (EGFR) degradation in EGF-stimulated gastric cancer cells. In addition, we found that HDAC6 inactivation recovered rabaptin 5, a Rab5 interacting protein potentiating Rab5, a small GTPase that regulates early endocytic events. These findings suggest that aberrant overexpression of HDAC6 confers gastric cancer cells to sustain EGF-signaling by retardation of EGFR degradation by way of repression of rababtin-5, and HDAC6 is a bona fide target for therapeutic intervention in gastric cancers. Note: This abstract was not presented at the meeting. Citation Format: Se Jin Park, Hyun Jin Bae, Jung Woo Eun, Qinngyu Shen, Hyung Seok Kim, Woo Chan Shin, Won Sang Park, Jung Young Lee, Suk Woo Nam. Aberrant expression of HDAC6 sustains malignant progression by preventing epidermal growth factor receptor degradation in gastric cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5261. doi:10.1158/1538-7445.AM2014-5261
Myocardial Infarction Risks Remain for Patients Undergoing Noncardiac Elective Surgery
Authors: Mike Mitka
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conditional Survival of Patients With the Four Major Histologic Subgroups of Lung Cancer in Denmark
Authors: Halla Skuladottir, Jørgen H. Olsen
Journal: Journal of Clinical Oncology (2003)

The survival probability of patients with lung cancer is usually based on the extent of disease as assessed at the time of diagnosis. The discouraging 5-year survival is often reported (< 10%) without taking into account changes in the survival probability as time advances from diagnosis.Conditional survival estimates by sex, age, extent of disease, and histology were estimated for patients diagnosed with lung cancer in Denmark from 1943 to 1997. Survival probabilities were calculated by the Kaplan-Meier method, and cumulative survival estimates were used to derive conditional survival estimates.For every additional year survived, the probability of surviving the next 5 years increases from 33% (men) and 36% (women) after the first year, to 60% (men) and 67% (women) who have survived 5 years. The 5-year survival probability of patients younger than 49 years who had survived the first year was 33%, and increased to 81% after the fifth year. Corresponding estimates for 60- to 69-year-old patients were 23% and 52%. The conditional survival differed greatly among patients with localized and regional disease (29% and 10%, respectively) in the first year, but converged with time (52% and 47%, respectively) after 5 years. The conditional survival is similar in patients with squamous cell carcinoma, adenocarcinoma, and large-cell carcinoma, but is markedly lower in patients with small-cell carcinoma.For patients who have survived more than 1 year, the conditional survival probability provides a more accurate estimate of survival as compared with the conventional observed survival rates.
Ribavirin or CpG DNA Sequence–Modulated Dendritic Cells Decrease the IgE Level and Airway Inflammation
Authors: Dian-Jung Chiang, Yi-Ling Ye, Wei-Li Chen, Yueh-Lun Lee, Ni-Yun Hsu, Bor-Luen Chiang
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Asthma is an allergic disease that is characterized by the imbalance between Th1 and Th2 cells and by the predominant Th2-type immune response. In this study, we investigated the application of dendritic cell (DCs)-based immunotherapy in modulating the immune response of allergic diseases. DCs incubated with ovalbumin (OVA), OVA plus ribavirin, OVA plus CpG-oligodeoxynucleotides (ODN 1826), or OVA plus non-CpG-ODN (ODN 1745) for 48 hours were injected intravenously into four corresponding groups of BALB/c mice. All of the mice were then immunized with OVA intraperitoneally 7 days later to establish an animal model of asthma. Serum levels of OVA antibody, airway hyperresponsivness, cell composition and cytokine levels in the bronchoalveolar lavage fluid, and cytokine profiles of spleen cells were analyzed. The data showed that ribavirin and ODN 1826 increased interleukin-12 synthesis and inhibited interleukin-10 production. ODN 1826 could also enhance the expression of B7.1, B7.2, major histocompatibility complex I, and major histocompatibility complex II molecules. Furthermore, the DCs modulated by ribavirin and ODN 1826 could downregulate the Th2-type immune response in vivo and could alleviate airway inflammation. This study elucidated the effect of ribavirin and CpG-ODN on DCs and demonstrated that in vitro modulated DCs might be a potential therapeutic approach for asthma.
Provision of Rehabilitation Services to the Physically Impaired in Ghetto Health Programs
Authors: A. D. Anderson, H. L. Thornhill
Journal: New England Journal of Medicine (1970)

IN his speech to the 1968 convention of the National Medical Association, former President Johnson proclaimed the "right of every American to as healthy a life as modern medicine can provide." To exist in the ghetto with a physical impairment, without care, is not to lead a "healthy life." We must go beyond prevention and treatment of disease to seek optimal levels of function. Consider a 17-year-old numbers runner who survives gunshot wounds of the chest, abdomen and spine, a modern surgical and nursing triumph. At the time he is declared to be dischargeable by the acute-care physician, he is . . .
A COMPARISON OF SIMPLE VERUS COMPLEX STRATEGY FOR CATHETER BASED TREATMENT OF CORONARY BIFURCATION LESIONS: META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Venkata Sai Srikanth Moningi, Mukesh Singh, Sasikanth Adigopula, Param Singh, Vamsi Kodumuri, Sandeep Khosla, Rohit Arora
Journal: Journal of the American College of Cardiology (2012)
Hyperlipidemia After Renal Transplantation: Natural History and Pathophysiology
Authors: D. C. CATTRAN
Journal: Annals of Internal Medicine (1979)

Twenty-five patients had their lipid profile monitored sequentially for up to 3 years post-transplant. All patients had a good graft function throughout the study. Forty-four percent remained hypertriglyceridemic. The lipid level was not due to diet or excessive weight gain. Triglyceride turnover studies showed that overproduction was the predominant defect in patients receiving massive steroids to reverse rejection and in stable long-term recipients. Repeat metabolic investigations in the latter group, after changing to alternate-day, equal-dose steroid therapy showed improvement in both the absolute triglyceride concentration and the triglyceride production rate. The correlation observed between basal insulin level and triglyceride concentration suggests the drug may act through this hormone, stimulating hepatic triglyceride production. A change to alternate-day steroid therapy should be considered in post-transplant patients who are hyperlipemic while receiving minimal daily prednisone therapy.
Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients
Authors: Jonathan C. Booth, Umesh Kumar, David Webster, John Monjardino, Howard C. Thomas
Journal: Hepatology (1998)

The hypervariable region (HVR) of the E2/NS1 region of hepatitis C virus (HCV) varies greatly between viral isolates with high rates of genomic change reported during the course of chronic infection. The HVR is thought to encode a structurally unconstrained envelope protein containing several linear B cell epitopes recognized by neutralizing antibody. It has been postulated that amino acid changes in the HVR could result from humoral immune pressure leading to the selection of escape mutants. The aim of this study was to compare the rates of nucleotide and amino acid variation in the HVR of control patients to patients with common variable immunodeficiency (CVID) where the effect of the humoral immune system is reduced. Five controls and four patients with CVID were studied. Serum samples were taken over periods of between 1 and 6 years. HCV was detected by polymerase chain reaction (PCR) with primers derived from conserved flanking regions of the HVR. PCR products were cloned into a plasmid vector and recombinant clones identified by restriction enzyme digestion. Purified DNA from at least three individual clones from each time point was sequenced by the dideoxynucleotide chain-termination method. Consensus sequences were extracted from the three clones, and the DNA and deduced protein sequences were compared. Control patients had a mean rate of nucleotide change of 6.954 nucleotide substitutions per year, compared with patients with CVID with a rate of 0.415 nucleotide substitutions per year ( P &lt; .02). The corresponding rates for amino acid variation were 3.868 amino acid substitutions per year for the control patients compared with 0.185 amino acid substitutions per year for the patients with CVID. These findings suggest that in the absence of humoral immune selective pressure, the frequency of occurrence of genetic variation in the major viral species is reduced. The mutations occur, but in the absence of immune selection remain as minor species. The evolution of viral mutants capable of evading the host’s immune system may contribute to the ability of HCV to establish chronic infection.
Mite and cat allergen levels in homes and severity of asthma.
Authors: M Chan-Yeung, J Manfreda, H Dimich-Ward, J Lam, A Ferguson, P Warren, E Simons, I Broder, M Chapman, T Platts-Mills
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The relationships between mite and cat allergen levels in the home, skin test reactivity, and severity of asthma were explored in 120 asthmatic subjects, 57 in Vancouver and 63 in Winnipeg. Patients in the two cities were similar in age, gender distribution, and severity of asthma. Skin tests were performed using 13 common allergens, including D. pteronyssinus, D. farinae, and cat dander, as well as control subjects. Patients recorded their asthma symptoms, medication requirement, and twice daily peak expiratory flow rate for 1 yr. Dust samples were collected every 3 mo during each season of 1992 through 1993 in both cities. Mite and cat allergen levels were determined with an ELISA using monoclonal antibodies against Der p I, Der f I, and Fel d I. There was no relationship between skin test reactivity and levels of mite and cat allergens. In children with positive skin tests to either mite allergen, total mite (sum of Der p I and Der f I) allergen level was positively related to the mean daily symptom score and negatively related to the daily mean PEF (% of predicted). There was no such relationship among adult asthmatic patients with positive skin tests to either mite allergen. No relationship was found between cat allergen level and the severity of asthma.
Endoscopic variceal ligation is superior to combined ligation and sclerotherapy for esophageal varices: A multicenter prospective randomized trial
Authors: Z. A. Saeed, G. V. Stiegmann, F. C. Ramirez, R. M. Reveille, J. S. Goff, K. S. Hepps, R. A. Cole
Journal: Hepatology (1997)

Patients who have bled from varices remain at risk for rebleeding. There is interest in methods that would enable rapid eradication of varices. The present trial was designed to study whether combining ligation with sclerotherapy will allow quicker eradication of varices than either modality alone. Patients with bleeding esophageal varices were randomized into ligation or combination therapy groups. Patients in the ligation group were treated with endoscopic rubber band ligation alone. In combination group patients, each variceal column was ligated distally and 1 mL of ethanolamine was injected proximal to each ligated site. Subsequent treatment sessions were at 7– to 14–day intervals until varices were eradicated. The clinical and endoscopic characteristics of 25 patients in the ligation group were similar to those of 22 patients in the combination group. Follow–up was up to 30 months. Active bleeding was controlled in 100% of patients in the ligation group and 75% of those in combination group ( P = NS). It took 3.3 ± .4 (range, 1–7) sessions to eradicate varices with ligation and 4.1 ± .6 (1–7) with combination therapy ( P = NS). Survival (four deaths in ligation group, 8 in combination group), rebleeding rate (25% vs. 36%), and varix recurrence (16% vs. 23%) also were similar. There were more complications with combination therapy, including deep ulcers (65% vs. 20%; P &lt; .05); dysphagia (30% vs. 0%; P &lt; .05), with three strictures requiring dilation; and pain (30% vs. 10%; P = NS). Our results show that sclerotherapy combined with ligation offers no benefit over ligation alone. The higher complication rate with combination therapy does not warrant this approach.
Portal-Vein Hypoplasia with Inferior Mesenteric Hypertension
Authors: John W. Bell
Journal: New England Journal of Medicine (1970)

DEVELOPMENTAL obstruction of the extra-hepatic portal vein is usually associated with hypertension of the gastrosplenic circuit. Hypertension in the inferior mesenteric venous bed presumably depends on the degree and duration of portal-vein anomaly.The patient described below had been having rectal bleeding throughout childhood. Because of its rarity and the normal barium studies, congestive venopathy in the inferior mesenteric veins was not suspected before operation.Case ReportA 20-year-old man was admitted to the hospital with bloody diarrhea of 2 days' duration. At a prior admission 6 months earlier, studies had established idiopathic hemorrhagic proctitis. The past history revealed intermittent . . .
So what's a modeler to do?
Authors: Esther Thelen, Gregor Schöner, Christian Scheier, Linda B. Smith
Journal: Behavioral and Brain Sciences (2001)

We argue that mentalistic constructs like the “object concept” are not substitutes for process explanations of cognition, and that it is impossible to prove the existence of such constructs with behavioral tasks. We defend the field theory as an appropriate level for modeling embodiment. Finally, we discuss the model's biological plausibility and its extensions to other tasks and other species.