tbuckley/cabot-search huggingface dataset:
Hospital waiting lists in England reach five year high
Authors: M. Limb
Journal: BMJ (2013)

The number of patients waiting for hospital treatment in England has risen to almost 2.9 million—a five year high—latest figures show.

NHS England published statistics on 15 August showing the latest data on waiting times from referral to treatment in the NHS for June 2013.1 They showed that there were around 2.88 million …
Immunotherapy of Myeloid Leukemia.
Authors: Joseph E. Sokal
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Immunotherapy of Myeloid Leukemia.Joseph E. Sokal, M.D., F.A.C.P., C. W. Aungst, M.D., F.A.C.P., James T. Grace Jr., M.D.Joseph E. Sokal, M.D., F.A.C.P.Search for more papers by this author, C. W. Aungst, M.D., F.A.C.P.Search for more papers by this author, James T. Grace Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-878_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDeath from chronic myelocytic leukemia usually results from myeloblastic transformation. In 1965, efforts were initiated to prevent or delay such death by immunizing patients with cultured cells established from blood of [1] a patient with acute myeloblastic leukemia (earlier vaccinations) and [2] a patient in blastic crisis of Ph′-positive chronic myelocytic leukemia (from 1970). Cells are mixed with BCG organisms as adjuvant, and injected intradermally. All patients continue on antileukemic chemotherapy. Of 21 patients who have received three or more vaccinations, 16 developed delayed hypersensitivity to the target cells, and 15 exhibited a general increase in cellular immune reactivity. The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDetection of cell-associated antigen in a blast crisis of chronic myeloid leukemia by the cytotoxic test with xenogeneic antibodiesA 5-YEAR CONTROLLED STUDY OF B.C.G. AND RADIOTHERAPY FOR INOPERABLE LUNG CANCERChronic Myeloid LeukemiaAerosol BCG treatment of carcinoma metastatic to the lung: A phase I studyBCG and CancerEffect of BCG on delayed hypersensitivity responses of patients with neoplastic disease 1 May 1972Volume 76, Issue 5Page: 878-878KeywordsAcute myeloid leukemiaBacille calmette guerinBlood cellsCellsChemotherapyChronic myelocytic leukemiaHypersensitivity Issue Published: 1 May 1972 PDF DownloadLoading ...
Idiopathic pulmonary fibrosis: can cell mediated immunity markers predict clinical outcome?
Authors: R Meliconi, E Lalli, R M Borzi, C Sturani, V Galavotti, G Gunella, R Miniero, A Facchini, G Gasbarrini
Journal: Thorax (1990)

Most of the cells found in lung parenchyma in patients with idiopathic pulmonary fibrosis are activated T lymphocytes and macrophages. The serum levels of three markers of cell mediated immunity were measured in 20 patients with idiopathic pulmonary fibrosis, in 20 normal subjects and in 12 patients with sarcoidosis to evaluate their clinical and prognostic significance in idiopathic pulmonary fibrosis. The three markers were: soluble CD8 (from activated suppressor-cytotoxic lymphocytes), soluble interleukin (IL)-2 receptors (from activated T cells and macrophages), and neopterin (from activated macrophages). Patients with idiopathic pulmonary fibrosis had higher levels of all three markers than the control subjects. Soluble IL-2 receptor and neopterin tended to be lower (though not significantly) in patients with idiopathic pulmonary fibrosis than in those with sarcoidosis, whereas soluble CD8 was similar in the two groups of patients. No correlation was found between soluble IL-2 receptors or soluble CD8 and the clinical, radiological, and physiological measures of disease activity or with clinical outcome (after a mean follow up of 23 months). Tumour necrosis factor levels were also determined. Only 30% of patients with idiopathic pulmonary fibrosis or sarcoidosis had detectable circulating tumour necrosis factor; these patients had a lower percentage of bronchoalveolar lavage fluid neutrophils in their lavage fluid. Tumour necrosis factor levels did not correlate with clinical measures of severity or outcome. Thus our data support the hypothesis that cell mediated alveolitis occurs in idiopathic pulmonary fibrosis. They do not, however, provide evidence to support the use of these markers of cell mediated immunity to monitor the clinical course in these patients.
Application of NT‐proBNP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure
Authors: Yoshihiko Seino, Akio Ogawa, Teruyo Yamashita, Masato Fukushima, Ken‐ichi Ogata, Hiroko Fukumoto, Teruo Takano
Journal: European Journal of Heart Failure (2004)
Effect of 20 mph traffic speed zones on road injuries in London, 1986-2006: controlled interrupted time series analysis
Authors: C. Grundy, R. Steinbach, P. Edwards, J. Green, B. Armstrong, P. Wilkinson
Journal: BMJ (2009)

<b>Objective</b> To quantify the effect of the introduction of 20 mph (32 km an hour) traffic speed zones on road collisions, injuries, and fatalities in London. <b>Design</b> Observational study based on analysis of geographically coded police data on road casualties, 1986-2006. Analyses were made of longitudinal changes in counts of road injuries within each of 119 029 road segments with at least one casualty with conditional fixed effects Poisson models. Estimates of the effect of introducing 20 mph zones on casualties within those zones and in adjacent areas were adjusted for the underlying downward trend in traffic casualties. <b>Setting</b> London. <b>Main outcome measures</b> All casualties from road collisions; those killed and seriously injured (KSI). <b>Results</b> The introduction of 20 mph zones was associated with a 41.9% (95% confidence interval 36.0% to 47.8%) reduction in road casualties, after adjustment for underlying time trends. The percentage reduction was greatest in younger children and greater for the category of killed or seriously injured casualties than for minor injuries. There was no evidence of casualty migration to areas adjacent to 20 mph zones, where casualties also fell slightly by an average of 8.0% (4.4% to 11.5%). <b>Conclusions </b>20 mph zones are effective measures for reducing road injuries and deaths.
Increasing the number of organ transplants
Authors: T. Sackville
Journal: BMJ (1995)

EDITOR,—Colin Francome and colleagues advocate the system of organ donation known as presumed consent or opting out.1 I recognise that some people do not believe that the NHS's organ donor register will be effective, but most of those working in organ transplantation and the public generally have welcomed it. This is borne out by the encouraging response so far: in just eight months over one million people have applied to join the register.

I note the results …
Role of Biopersistence in the Pathogenicity of Man-made Fibers and Methods for Evaluating Biopersistence: A Summary of Two Round-table Discussions
Authors: Roger O. McClellan, Thomas W. Hesterberg
Journal: Environmental Health Perspectives (1994)

This paper summarizes two roundtable discussions held at the conclusion of the International Conference on Biopersistence of Respirable Synthetic Fibres and Minerals. The first round table addressed the role of biopersistence in the pathogenicity of fiber-induced disease. The panel included T. W. Hesterberg (Chairman), J.M.G. Davis, K. Donaldson, B. Fubini, N.F. Johnson, G. Oberdoerster, P. Sébastien, and D. Warheit. The second panel addressed the issue of methods for assessing biopersistence. It included R.O. McClellan (Chairman), J. Brain, A. Langer, A. Morgan, C. Morscheidt, H. Muhle, and R. Musselman. The two chairmen acknowledge the excellent contributions of all the members of the panels, whose comments formed the basis of this summary. Nonetheless, the authors assume full responsibility for the written text, recognizing that it was not reviewed by the discussants of the two panels.-Environ Health Perspect 102(Suppl 5):277-283 (1994)
The Little Laundress
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)
Authors: Oliver C. Goodyear, Mike Dennis, Nadira Y. Jilani, Justin Loke, Shamyla Siddique, Gordon Ryan, Jane Nunnick, Rahela Khanum, Manoj Raghavan, Mark Cook, John A. Snowden, Mike Griffiths, Nigel Russell, John Yin, Charles Crawley, Gordon Cook, Paresh Vyas, Paul Moss, Ram Malladi, Charles F. Craddock
Journal: Blood (2012)
Lords reject legalisation of euthanasia
Authors: S Kingman
Journal: BMJ (1994)

It should remain a crime for a doctor to kill a patient intentionally even when the patient requests it, said an all party committee of the House of Lords last week. There would be no way of ensuring that all such acts were truly voluntary, and people who were elderly, lonely, sick, or otherwise vulnerable might feel under pressure, real or imagined, to request early death. Lord Walton, who chaired the select committee on medical ethics, said that if either voluntary euthanasia or assisted suicide were to be legalised “there would be certain people who for personal and possibly unscrupulous reasons …
Textbook of Travel Medicine and Health
Authors: Joan Bowes Ritter
Journal: Annals of Internal Medicine (1997)

Medical Writings15 August 1997Textbook of Travel Medicine and HealthJoan Bowes Ritter, MDJoan Bowes Ritter, MDWalter Reed Army Medical Center, Washington, D.C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-4-199708150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Textbook of Travel Medicine and HealthDuPont HL, Steffen R; eds. 370 pages. BC Decker; 1997. $125.00. ISBN 1550090372.Field of medicine: Infectious diseases, internal medicine, and primary care.Format: Hardcover book.Audience: A complete reading of this book will be useful for the specialist in infectious diseases. Primary care physicians will find it a good resource in counseling and evaluating patients who travel.Purpose: To prevent disease and provide optimal medical care for the traveling public and to define the boundaries of the new and expanding field of travel medicine.Content: The textbook reviews every aspect of health as ... Author, Article, and Disclosure InformationAffiliations: Walter Reed Army Medical Center, Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1997Volume 127, Issue 4Page: 336KeywordsGeographic areasGlobal healthHealth information technologyInfectious diseasesMalariaOxygenPopulation statisticsPregnancyPrimary care physiciansProphylaxis ePublished: 15 August 2000 Issue Published: 15 August 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27Kip1 and control of cyclin D1 expression
Authors: A Cappellini, G Tabellini, M Zweyer, R Bortul, P L Tazzari, A M Billi, F Falà, L Cocco, A M Martelli
Journal: Leukemia (2003)
Visiting Patients in Their Homes
Authors: Michael F. Loudon
Journal: JAMA (1988)

British general practitioners (GPs) make many more visits to patients in their homes than do their American counter-parts—during the day, at the weekend, and at night.<sup>1</sup>We soon learn that the act of placing a plate of food on our dining tables triggers, telekinetically, a telephone call from a patient. Other reliable psychic stimuli include going to the lavatory, placing one foot into a warm bath (it doesn't matter which foot), and getting into bed with one's beloved before midnight. For me, the most reliable stimulus of all is sitting down in front of my television to watch "Hill Street Blues." For this reason alone I have often come close to wasting money on a video recorder. It is a condition of National Health Service general practice that the GP agrees to visit the patient at home if so requested. provided that in his or her opinion the request
Characteristic Appearance of Facet Osteoarthritis of the Lower Lumbar Spine on Planar Bone Scintigraphy With a High Negative Predictive Value for Metastasis
Authors: Chun K. Kim, Kyong-Won Park
Journal: Clinical Nuclear Medicine (2008)

Purpose: The spine is a common site of various pathologic changes. On bone scans, differential diagnosis between metastasis and benign changes is not always easy. We describe a characteristic bone scan appearance of facet osteoarthritis most often seen at the fifth lumbar level. The lesion typically appears oval/elongated in shape, located along the lateral margin of the spine; its superior end is usually outside (lateral to) or just at the margin of the spine, and the inferior end is just at or inside (medial to) the margin, yielding a pattern of slightly oblique activity. Materials and Methods: Bone scans performed in 448 patients with known malignancy and interpreted as having some sort of spinal abnormalities were reviewed. Of these, the scans in 36 patients were judged to show the facet osteoarthritis sign (FOS). Follow-up was available in 28 of the 36 patients. The presence or absence of metastasis at the site of the FOS was determined by a minimum of 6-month follow-up by chart review and correlation with plain radiographs, computed tomography (CT), magnetic resonance imaging, and/or serial bone scans. Results: None of the 28 patients had metastasis at the site of the FOS. CT and/or plain radiographs performed in 13 patients invariably showed facet disease. Conclusion: When planar bone scan images show the FOS, further evaluation of this region with SPECT imaging or other imaging, ie, plain radiography, CT, or magnetic resonance imaging, would be unnecessary because this sign has an extremely high negative predictive value for metastasis (100% in this series).
Focusing in on P53 in hepatocellular carcinoma
Authors: David Carbone
Journal: Hepatology (1991)

Human hepatocellular carcinomas (HCC) from patients in Qidong, an area of high incidence in China, in which both hepatitis B virus and aflatoxin B 1 are risk factors, were analysed for mutations in p53, a putative tumour-suppressor gene. Eight of the 16 HCC had a point mutation at the third base position of codon 249. The G→T transversion in seven HCC DNA samples and the G→C transversion in the other HCC are consistent with mutations caused by aflatoxin B 1 in mutagenesis experiments. No mutations were found in exons 5, 6, 8 or the remainder of exon 7. These results contrast with p53 mutations previously reported in carcinomas and sarcomas of human lung, colon, oesophagus and breast; these are primarily scattered over four of the five evolutionarily conserved domains, which include codon 249. We suggest that the mutant p53 protein may be responsible for a selective clonal expansion of hepatocytes during carcinogenesis. Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991;350:429-431. Hepatocellular carcinoma (HCC) is a prevalent cancer in sub-Saharan Africa and eastern Asia. Hepatitis B virus and aflatoxins are risk factors for HCC, but the molecular mechanism of human hepatocellular carcinogenesis is largely unknown. Abnormalities in the structure and expression of the tumour-suppressor gene p53 are frequent in HCC cell lines, and allelic losses from chromosome 17p have been found in HCCs from China and Japan. Here we report on allelic deletions from chromosome 17p and mutations of the p53 gene found in 50% of primary HCCs from southern Africa. Four of five mutations detected were G→T substitutions, with clustering at codon 249. This mutation specificity could reflect exposure to a specific carcinogen, one candidate being aflatoxin B 1 , a food contaminant in Africa, which is both a mutagen that induces G to T substitution and a liver-specific carcinogen.
Do von Willebrand victims have less plaque?
Authors: Phil Gunby
Journal: JAMA (1980)

There now is a registry of patients with the congenital coagulation disorder called von Willebrand's disease, particularly the more severe forms. National Heart, Lung, and Blood Institute (NHLBI) officials in Bethesda, Md, say that when the needed technology becomes available—probably in the form of refinements in ultrasound equipment and techniques—some of these patients probably will be asked to take part in prospective studies on the development of atherosclerosis. One hypothesis is that at least the severe forms of von Willebrand's disease (named for the Finnish physician who first reported it in 1926) may protect against atherosclerosis. If ultrasound monitoring lives up to expectations, it may be possible to study the blood vessels of such patients noninvasively to see if atherosclerotic plaque forms. According to the NHLBI, 344 patients on the list are classified as having severe von Willebrand's disease, while 115 have less serious forms. Harvey J. Weiss, MD, professor
Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy.
Authors: S J Hwang, M Haas, H W Harris, P Silva, S Yalla, M R Sullivan, G Otuechere, M Kashgarian, M L Zeidel
Journal: Journal of Clinical Investigation (1993)

To characterize the sodium transport defect responsible for salt wasting in obstructive nephropathy, the major sodium transporters in the medullary thick ascending limb (mTAL), the apical Na-K-2Cl cotransporter and the basolateral Na-K-ATPase, were studied in fresh suspensions of mTAL cells and outer medulla plasma membranes prepared from obstructed and untreated kidneys. Oxygen consumption (QO2) studies in intact cells revealed marked reductions in the inhibitory effects of both furosemide and ouabain on QO2 in cells from obstructed, as compared with control animals, indicating a reduction in activities of both the Na-K-2Cl cotransporter and the Na-K-ATPase. Saturable [3H]bumetanide binding was reduced in membranes isolated from obstructed kidneys, but the Kd for [3H]bumetanide was unchanged, indicating a decrease in the number of functional luminal Na-K-2Cl cotransporters in obstructed mTAL. Ouabain sensitive Na-K-ATPase activity in plasma membranes was also reduced, and immunoblots using specific monoclonal antibodies directed against the alpha and beta subunits of rabbit Na-K-ATPase showed decreased amounts of both subunits in outer medullas of obstructed kidney. A significant decrease in [3H]bumetanide binding was detected after 4 h of ureteral obstruction, whereas Na-K-ATPase activity at this time was still not different from control. We conclude that ureteral obstruction reduces the amounts of both luminal Na-K-2Cl cotransporter and basolateral Na-K-ATPase in mTAL of obstructed kidney and that these reductions contribute to the salt wasting observed after release of obstruction.
Systematic review did not consider problem of treatment effects
Authors: S. M. Liew, J. Doust, P. Glasziou
Journal: BMJ (2012)

Siontis and colleagues’ systematic review comparing established risk prediction models for cardiovascular disease is a useful validation of previous studies,1 but they seem to have ignored the problem of treatment effects.

We found in our review that none of the available risk scores adjusted for the treatment of risk factors in their populations.2 Ignoring the effect …
Cetirizine treatment of allergic cough in children with pollen allergy
Authors: G. Ciprandi, M. Tosca, V. Ricca, G. Passalacqua, L. Fregonese, L. Fasce, G. W. Canonica
Journal: Allergy (1997)

Cetirizine, an antihistamine widely used in the treatment of allergic rhinoconjunctivitis, also has antiallergic activity. The present study aimed to evaluate cetirizine as a treatment for children with allergic cough due to pollen allergy. This was a parallel-group, double-blind, placebo-controlled, randomized study. Twenty children with pollinosis were enrolled: they were subdivided into two groups receiving a 1-month treatment during the pollen season. The following variables were monitored: 1) clinical symptoms and respiratory data (spirometry and PEF) evaluated at baseline and at the end of the study by allergists and by a daily diary card, and 2) pollen count. This study shows that cetirizine treatment reduces cough intensity (P < 0.05) and frequency (P < 0.01). In conclusion, cetirizine does clinically improve cough due to pollen allergy.
Reply from Authors re: Quoc-Dien Trinh, Khurshid R. Ghani, Mani Menon. Robot-assisted Radical Prostatectomy: Ready To Be Counted? Eur Urol 2012;62:16–8
Authors: Ashutosh Tewari, Anthony Pham, Abhishek Srivastava, Robert Leung, Prasanna Sooriakumaran, Dan Bloch, Usha Seshadri-Kreaden, April E. Hebert, Peter Wiklund
Journal: European Urology (2012)
The occurrence of falls among patients with a new episode of hip pain
Authors: E. S Nahit, A. J Silman, G. J Macfarlane
Journal: Annals of the Rheumatic Diseases (1998)

<h3>OBJECTIVES</h3> To establish the risk of falling among those who consult their general practitioner with a new episode of hip pain and to discover if risk is altered by age and according to whether, at presentation, signs of osteoarthritis are present on radiography. <h3>METHODS</h3> A case-control study was conducted. Cases were all patients who presented with a new episode of hip pain to participating general practices throughout the United Kingdom. All cases had a pelvic radiograph taken on recruitment to the study. Three controls were matched for sex, age, and general practice to each case. A questionnaire was sent by post to all cases and controls. The risk of having fallen in the past 12 months among cases and controls was compared. <h3>RESULTS</h3> The study included 111 cases presenting with hip pain and 229 controls who had not consulted with hip pain in the previous 12 months. Women (odds ratio = 3.6, 95% CI 1.9, 6.7) but not men (odds ratio = 0.8, 95% CI 0.3, 2.3) reported an increased risk of falling in the previous 12 months. Similar results were obtained when the previous four months were considered. For all cases, hip pain predated any reported falls. The increased risk in women was found particularly for those aged less than 70. Risk of falling was not altered by the presence of radiological changes of osteoarthritis. <h3>CONCLUSIONS</h3> Hip pain, which may be a symptom of osteoarthritis of the hip, increases the risk of falling. This finding has implications for the advice offered by general practitioners to patients who consult with early hip pain.