Musculoskeletal Disorders After Renal Homotransplantation
Authors: JAIME F. BRAVO
Journal: Annals of Internal Medicine (1967)

Article1 January 1967Musculoskeletal Disorders After Renal HomotransplantationA Clinical and Laboratory Analysis of 60 CasesJAIME F. BRAVO, M.D., JEROME H. HERMAN, M.D., CHARLEY J. SMYTH, M.D. F.A.C.P.JAIME F. BRAVO, M.D.Search for more papers by this author, JEROME H. HERMAN, M.D.Search for more papers by this author, CHARLEY J. SMYTH, M.D. F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-1-87 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years evidence has accumulated that immunological phenomena may be involved, at least secondarily, in the pathogenesis of some of the rheumatic diseases. Similar phenomena occur in the recipients of renal homografts as a result of indigenous incompatibility factors existing between the host and recipient tissues. Waller, Irby, Mullinax, and Toone (1) recently reported connective-tissue disorders characterized by periarticular pain, transient synovitis, dermatologic lesions, and peripheral neuritis in 12 of 21 recipients of renal homotransplants. Rheumatoid-factor activity was detected in the sera of 66% of their patients. These findings led to investigations reported here of the mechanisms operative in...References1. WALLERIRBYMULLINAXTOONE MRFEC: Connective-tissue diseases and rheumatoid factors in patients with renal transplants. New Eng. J. Med. 273: 12, 1965. CrossrefMedlineGoogle Scholar2. PEARSON CM: Personal communication. Google Scholar3. STERNHEIMERMALBIN RB: Clinical recognition of pyelonephritis, with a new stain for urinary sediments. Amer. J. Med. 11: 312, 1951. CrossrefMedlineGoogle Scholar4. DJANIANBEUTNERWITEBSKY AYEHE: Tanned-cell hemagglutination test for detection of antibodies in sera of patients with myasthenia gravis. J. Lab. Clin. Med. 63: 60, 1964. MedlineGoogle Scholar5. OUCHTERLONY #: Antigen-antibody reactions in gels. Acta Path. Microbiol. Scand. 32: 231, 1953. CrossrefGoogle Scholar6. CLAMANMERRILL HNDA: Quantitative measurement of human gamma-2, beta-2A, and beta-2M serum immunoglobulins. J. Lab. Clin. Med. 64: 685, 1964. MedlineGoogle Scholar7. SCHEIDEGGER JJ: Une micro-méthode de l'immuno-électrophorèse. Int. Arch. Allerg. 7: 103, 1955. CrossrefGoogle Scholar8. SEARCYBERGQUIST RLLM: A new color reaction for the quantitation of serum cholesterol. Clin. Chim. Acta 5: 192, 1960. CrossrefMedlineGoogle Scholar9. VAN HANDELZILVERSMIT EDB: Micro-method for the direct determination of serum triglycerides. J. Lab. Clin. Med. 50: 152, 1957. MedlineGoogle Scholar10. LEVEILLESHOCKLEYSAUBERLICH GAJWHE: The influence of cholesterol on the determination of serum glycerides. U. S. Army Med. Res. Nutr. Lab. Rep. 255: 1, 1961. Google Scholar11. FISKESUBBAROW CHY: The colorimetric determination of phosphorus. J. Biol. Chem. 66: 375, 1925. CrossrefGoogle Scholar12. HUERGAYESINICKPOPPER JDCH: Estimation of total serum lipids by a turbidimetric method. Amer. J. Clin. Path. 23: 1163, 1953. CrossrefMedlineGoogle Scholar13. DOLEMEINERTZ VPH: Microdetermination of long-chain fatty acids in plasma and tissues. J. Biol. Chem. 235, 2595, 1960. CrossrefMedlineGoogle Scholar14. LIDDLESEEGMILLERLASTER LJEL: The enzymatic spectrophotometric method for determination of uric acid. J. Lab. Clin. Med. 54: 903, 1959. MedlineGoogle Scholar15. DORNERGANTNERUDDINZUCKNER RWGEJJ: The use of ultrasound in synovial fluid analysis. Arthritis Rheum. 8: 368, 1965. CrossrefMedlineGoogle Scholar16. ABRUZZOCHRISTIAN JLCL: Induction of a rheumatoid factor-like substance in rabbits. J. Exp. Med. 114: 791, 1961. CrossrefMedlineGoogle Scholar17. MILGROMWITEBSKY FE: Rabbit antibodies against gamma globulins resembling the rheumatoid factor. Fed. Proc. 19: 197, 1960. Google Scholar18. BONOMOLOSPALLUTOZIFF LJM: Antigamma globulin factors in liver disease. Arthritis Rheum. 6: 104, 1963. CrossrefMedlineGoogle Scholar19. KUNKELSIMONFUDENBERG HGHJH: Observations concerning positive serologic reactions for rheumatoid factor in certain patients with sarcoidosis and other hyperglobulinemic states. Arthritis Rheum. 1: 289, 1958. CrossrefMedlineGoogle Scholar20. PELTIERCHRISTIAN ACL: The presence of the rheumatoid factor in sera from patients with syphilis. Arthritis Rheum. 2: 1, 1959. CrossrefMedlineGoogle Scholar21. WILLIAMSKUNKEL RCHG: Rheumatoid factor, complement, and conglutinin aberrations in patients with subacute bacterial endocarditis. J. Clin. Invest. 41: 666, 1962. CrossrefMedlineGoogle Scholar22. CATHCARTWILLIAMSROSSCALKINS ESRCHE: The relationship of the latex fixation test to the clinical and serologic manifestations of leprosy. Amer. J. Med. 31: 758, 1961. CrossrefMedlineGoogle Scholar23. SINGERPLOTZPERALTALYONS JMCMFMHC: The presence of anti-gamma globulin factors in sera of patients with active pulmonary tuberculosis. Ann. Intern. Med. 56: 545, 1962. LinkGoogle Scholar24. PORTERCALNE KARY: Origin of the infiltrating cells in skin and kidney homografts. Transplant. Bull. 26: 458, 1960. CrossrefMedlineGoogle Scholar25. WHEELERCORSON HBJM: Graft-host interactions after kidney slice transplantation in inbred mice. Surg. Forum 11: 472, 1960. MedlineGoogle Scholar26. JONESENGLEMANNAJARIAN JPEPJS: Systemic fat embolism after renal homotransplantation and treatment with corticosteroids. New Eng. J. Med. 273: 1453, 1965. CrossrefMedlineGoogle Scholar27. WOOLGOLDSTEIN IGMS: Role of neurohumors in action of adrenal cortical steroids: mobilization of fat. Amer. J. Physiol. 175: 303, 1953. CrossrefMedlineGoogle Scholar28. TIMIRASKOCH PSP: Morphological and chemical changes elicited in liver of rabbits by cortisone and desoxycorticosterone acetate. Anat. Rec. 113: 349, 1952. CrossrefMedlineGoogle Scholar29. SHAFRIRSTEINBERG ED: The essential role of the adrenal cortex in the response of plasma free fatty acids, cholesterol, and phospholipids to epinephrine injection. J. Clin. Invest. 39: 310, 1960. CrossrefMedlineGoogle Scholar30. HILL RB: Fatal fat embolism from steroid-induced fatty liver. New Eng. J. Med. 265: 318, 1961. CrossrefGoogle Scholar31. STEINBERGWEBBRAFSKY HWMHA: Hepatomegaly with fatty infiltration secondary to cortisone therapy—case report. Gastroenterology 21: 304, 1952. CrossrefMedlineGoogle Scholar32. MORAN TJ: Cortisone-induced alterations in lipid metabolism. Morphologic and serologic observations in rabbits. Arch. Path. (Chicago) 73: 300, 1962. MedlineGoogle Scholar33. KENT SP: Fat embolism in diabetic patients without physical trauma. Amer. J. Path. 31: 399, 1955. MedlineGoogle Scholar34. STARZL TE: Personal communication. Google Scholar35. JONESENGLEMANSTEINBACHMURRAYRAMBO JPEHLWRON: Fat embolization as a possible mechanism producing avascular necrosis(abstract). Arthritis Rheum. 8: 449, 1965. Google Scholar36. SWEETNAMMASONMURRAY DRRMRO: Steroid arthropathy of the hip. Brit. Med. J. 1: 1392, 1960. CrossrefMedlineGoogle Scholar37. HEIMANNFREIBERGER WGRH: Avascular necrosis of the femoral and humeral heads after high-dosage corticosteroid therapy. New Eng. J. Med. 263: 672, 1960. CrossrefMedlineGoogle Scholar38. BOKSENBAUMMENDELSON MCG: Aseptic necrosis of the femoral head associated with steroid therapy. JAMA 184: 262, 1963. CrossrefMedlineGoogle Scholar39. PORTERTHOMSONOWENKENYONMOWBRAYPEART KAWBKJRJFWS: Obliterative vascular changes in four human kidney homotransplants. Brit. Med. J. 2: 639, 1963. CrossrefMedlineGoogle Scholar40. DUNEAHAZARDKOLFF GJBWJ: Vascular changes in renal homografts. JAMA 190: 199, 1964. CrossrefMedlineGoogle Scholar41. HOLLANDERMCCARTYRAWSON JLDJAJ: The "R.A. cell," "ragocyte," or "inclusion body cell." Bull. Rheum. Dis. 16: 382, 1965. MedlineGoogle Scholar42. SLOCUMB CH: Symposium on certain problems arising from clinical use of cortisone; rheumatic complaints during chronic hypercortisonism and syndromes during withdrawal of cortisone in rheumatic patients. Mayo Clin. Proc. 28: 655, 1953. MedlineGoogle Scholar43. ROTSTEINGOOD JRA: Steroid pseudorheumatism. Arch. Intern. Med. (Chicago) 99: 545, 1957. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAIME F. BRAVO, M.D.; JEROME H. HERMAN, M.D.; CHARLEY J. SMYTH, M.D. F.A.C.P.Affiliations: Denver, ColoradoFrom the Department of Medicine, Division of Rheumatic Diseases, University of Colorado School of Medicine, Denver, Colo.This study was supported by grants from the Geigy Pharmaceuticals Division of Geigy Co., Inc., Yonkers, N. Y., and by arthritis training grant 3T1 AM 5073, the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Charley J. Smyth, M.D., 4200 E. Ninth Ave., Denver, Colo. 80220. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosis of Joint DisordersDiseases of Joints and Soft-Tissue InfectionsDiseases of Joints and Soft-Tissue InfectionsCalcineurin-inhibitors and bone pain after organ transplantationResponse to ‘Calcineurin-inhibitors and bone pain after organ transplantation’Septic arthritis caused by nocardia asteroides in a renal transplant recipientDiagnosis of Joint DisordersSirolimus (rapamycin) in clinical transplantationInfective ArthritisDISTAL LOWER LIMB BONE PAIN AFTER RENAL TRANSPLANTATIONOsteonecrosis of the femoral condyle after arthroscopic reconstruction of a cruciate ligament. 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Part-IIIVascular calcification and peripheral necrosis in a renal transplant recipientFrequency and specificity of Antiglobulins of Intermediate TypeRenal TransplantationDiseases of Joints and Soft-Tissue InfectionsAvascular Necrosis in Cadaveric Renal AllograftsAutoimmunitySpontaneous Osteonecrosis of the KneeIMMUNOLOGICAL ASPECTS OF ORGAN AND TISSUE TRANSPLANTATIONLaboratory Studies in the Diagnosis of Rheumatoid ArthritisHuman Tissue Transplantation 1 January 1967Volume 66, Issue 1Page: 87-104KeywordsMetabolic disordersNecrosisOsteoporosisPathogenesisPathogensRenal diseasesRenal transplantationRheumatic feverSurgeryTransplantation ePublished: 1 December 2008 Issue Published: 1 January 1967 PDF downloadLoading ...