tbuckley/cabot-search huggingface dataset:
Intradermal influenza vaccination in complete remission cancer patients: molecular insights
Authors: Davide Bedognetti, Maria Libera Ascierto, Marimo Sato-Matsushita, Elena Gugiatti, Carlotta Massucco, Simonetta Zupo, Antonio Di Meglio, Chiara Dellepiane, Mario Roberto Sertoli, Omar Racchi, Enrico Balleari, Valeria De Giorgi, Michele Sommariva, Paolo Durando, Manlio Ferrarini, Roberto Cacciani, Nicoletta Provinciali, Rocco Iudici, Cristiano Alicino, Ena Wang, Filippo Ansaldi, Francesco M Marincola, Andrea De Maria
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts We previously showed that long-lasting complete remission (CR) non-Hodgkin lymphoma (NHL) patients treated with rituximab-containing chemotherapy have an attenuated antibody response to virosomal (Bedognetti et al, J. Immunology, 2011) or MF-59 adjuvanted (Bedognetti et al, Blood
Nurse shortage threatens UK care
Authors: L. McKee
Journal: BMJ (1998)

<h3>Abstract</h3> Cargo proteins of the type IX secretion system (T9SS) in human pathogens from phylum Bacteroidetes invariably possess a conserved C-terminal domain (CTD) that functions as a signal for outer membrane (OM) translocation. In <i>Porphyromonas gingivalis</i>, the CTD of selected cargos is cleaved off after translocation, and anionic lipopolysaccharide (A-LPS) is attached. This transpeptidase reaction anchors secreted proteins to the OM. PorZ, a cell surface-associated protein, is an essential component of the T9SS whose function was previously unknown. We recently solved the crystal structure of PorZ, and found that it consists of two β-propeller moieties followed by a CTD. In this study, we performed structure-based modelling suggesting that PorZ is a carbohydrate-binding protein. We found that recombinant PorZ specifically binds A-LPS. Binding was blocked by monoclonal antibodies that specifically react with a phosphorylated branched mannan in the anionic polysaccharide (A-PS) component of the A-LPS, but not with the core oligosaccharide or the lipid A endotoxin. Examination of A-LPS derived from a cohort of mutants producing various truncations of A-PS confirmed that the phosphorylated branched mannan is indeed the PorZ ligand. Moreover, purified recombinant PorZ interacted with the PorU sortase in an A-LPS–dependent manner. This interaction on the cell surface is crucial for the function of the attachment complex composed of PorU, PorZ, and the integral OM β-barrel proteins PorV and PorQ, which is involved in post-translational modification and retention of T9SS cargos on the bacterial surface. <h3>Author summary</h3> Bacteria have evolved multiple systems to transport effector proteins to their surface or into the surrounding milieu. These proteins have a wide range of functions, including attachment, motility, nutrient acquisition, and toxicity in the host. <i>Porphyromonas gingivalis</i>, the human pathogen responsible for severe gum diseases (periodontitis), uses a recently characterized type IX secretion system (T9SS) to translocate and anchor secreted virulence effectors to the cell surface. Anchorage is facilitated by sortase, an enzyme that covalently attaches T9SS cargo proteins to a unique anionic lipopolysaccharide (A-LPS) moiety of <i>P. gingivalis</i>. Here, we show that the T9SS component PorZ interacts with sortase and specifically binds A-LPS. Binding is mediated by a phosphorylated branched mannan repeat in A-LPS polysaccharide. A-LPS– bound PorZ interacts with sortase with significantly greater affinity, facilitating modification of cargo proteins by the cell-surface attachment complex of the T9SS.
Haemagglutinating anti-actin antibodies in acute and chronic liver disease
Authors: A N Hamlyn, P A Berg
Journal: Gut (1980)

Anti-actin antibody was measured by the passive haemagglutination test in the serum of 118 patients with various forms of chronic cholestatic and non-cholestatic liver disease, and of 23 patients with acute hepatitis B or non-A, non-B. Tanned sheep erythrocytes and electrophoretically pure actin prepared from rabbit skeletal muscle were employed; absorption tests confirmed the specificity of positive reactions, defined from healthy controls as a titre of greater than 1/80. The presence of anti-actin activity in chronic liver disease corresponded generally to the immunofluorescent demonstration of smooth muscle antibody (P&lt;0·01). However, in acute hepatitis, with one exception (later progressing to subacute disease) raised anti-actin titres were not found. Thus, the weak smooth muscle antibody occasionally demonstrable in this condition may be neither IgM in class, nor directed against actin. Anti-actin antibody was present in significantly high titre in 54% of 37 active chronic hepatitis patients and 79% of 24 `mixed-form9 cholestatic active chronic hepatitis, as compared with only 21% of 29 primary biliary cirrhosis patients, and 11% of alcoholic liver disease. Anti-actin antibody is therefore associated with chronic autoimmune parenchymal liver damage and its appearance may mark the transition from acute hepatitis. No raised anti-actin titres were seen in 10 primary biliary cirrhosis patients positive for mitochondrial antibody by indirect immunofluorescence, but negative by the complement fixation test. This result suggests that the cytoplasmic fluorescence observed is due to low titre mitochondrial antibody rather than cytoplasmic actin and that these patients do not represent a different disease entity. The generation of anti-actin antibody in chronic parenchymal liver disease, perhaps due to unmasking or schlepping of intracellular or SIg/HLA-associated actin, may characterise autoimmune events at hepatocyte level, point to prognosis, and aid in the differential diagnosis of individual patients.
Myocardial Infarction Without Atherosclerosis
Authors: Melvin D. Cheitlin
Journal: JAMA (1975)

By far the most frequent pathologic condition preceding myocardial infarction is coronary atherosclerosis. Because the great majority of patients who are first seen with acute myocardial infarction have atherosclerotic coronary artery disease, there is usually little thought given to other causes, except in children where congenital coronary anomalies are considered. However, there are multiple other conditions, albeit far rarer than atherosclerosis, that can result in clinical acute myocardial infarction, and a classification of these other conditions, an anatomic-pathophysiologic one, was developed from illustrative material from the files of the Armed Forces Institute of Pathology. This classification is an inclusive listing of all conditions, however unusual, that can result in acute myocardial infarction.
Follow-Up after Endoscopic Snare Resection of Duodenal Adenomas
Authors: D. Apel, R. Jakobs, A. Spiethoff, J. Riemann
Journal: Endoscopy (2005)

Premalignant duodenal polyps are considered to be rare. Recurrence after local excision is reported to be frequent, so many authors propose radical surgical treatment of these tumors. The aim of this study was to determine the long-term outcome after endoscopic resection of duodenal adenomas.Between January 1990 and April 2003 we retrospectively evaluated a group of patients who presented with nonampullary duodenal villous tumors but who did not have a polyposis syndrome.Duodenal polyps were diagnosed in 21 patients during routine endoscopy during the study period. Of these, 18 patients (6 men, 12 women; median age 67, range 50 - 81), with a total of 20 duodenal adenomas, were enrolled into the study. The median size +/- SD of the tumors was 27.5 +/- 12 mm (range 8 - 50 mm). Of these 20 tumors, 18 adenomas were tubulovillous, one was tubulous and one was villous. Nineteen polyps were treated by snare excision and one adenoma was treated with argon plasma coagulation alone. Argon plasma coagulation was applied to polyps in six patients after snare excision during this initial treatment phase. The success rate for endoscopic adenoma removal after a 3-month interval was 55 %. After a median follow-up period of 71 months (range 22 - 151 months), 12 patients remained in remission. Local recurrences of the lesion occurred in five patients (25 %) and these were re-treated. None of the patients developed carcinoma during the follow-up period.Endoscopic snare excision of duodenal adenomas is an effective mode of treatment but an endoscopic surveillance program is mandatory in order to detect and treat recurrence.
Letter: Serotonin metabolism in hepatic encephalopathy.
Authors: P Pentikainen, M Kekki
Journal: BMJ (1974)

1: 16).After the epidemic 89 (77%) had a four-fold titre rise.Of those under 20 years of age 46 out of 50 had posi,tive titres after the infection.Clinical illness occurred in over 50% of infected subjects.Five years later a follow-up study was done using 75-g oral carbohydrate load glucose tolerance test.Serum neutralizing antibody titres and two-hour plasma glucose levels were measured.Of the 136 persons under 25 years of age (M.= 65, F.= 71) the highest two-hour plasma glucose was 133 mg/100 ml.Persistence of positive titre levels was also documented since 77% of these subjects had a positive neutralizing antibody titre level.Even though it was in the young diabetic that Dr. Gamble and his colleagues were able to show the strongest association with positive Coxsackie B4 titres we could not show that Coxsackie B4 infection caused a single case of diabetes, though the attack rate in the 136 under 20 years of age at the time of the epidemic was extremely high.-We are, etc.,
Electrosurgical Hazards In Laparoscopy
Authors: Stephen L. Corson
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The letter of Neufeld et al (226:1465, 1973) points out some of the electrosurgical risks associated with operative laparoscopy but omits a most important piece of information. The authors identify neither the electrosurgical source nor the settings used. As we discussed in a recent publication,<sup>1</sup>the use of spark-gap units at high settings can generate enormous voltages and currents, promoting undesired spread of electrical, or more correctly, high-frequency wave, energy along various undesired pathways. The safest type of unit to use is a solid-state, low-energy machine with isolated circuitry. This factor is of far more importance than laparoscopic design per se and can reduce three-fold the power delivered to the patient. Since we switched to these units, no burn to patient or doctor has been observed. A dielectric eyepiece should be added to the telescope (advocated by most equipment companies) as a simple preventive of facial
Epstein-Barr virus-positive blastoid nasal T/natural killer-cell lymphoma in a caucasian
Authors: T.C. Ling, M. Harris, N.M. Craven
Journal: British Journal of Dermatology (2002)

Journal Article Epstein–Barr virus‐positive blastoid nasal T/natural killer‐cell lymphoma in a caucasian Get access T.C. Ling, T.C. Ling Department of Dermatology, Burnley General Hospital, Burnley BB10 2PQ, U.K Search for other works by this author on: Oxford Academic Google Scholar M. Harris, M. Harris Department of Histopathology, Christie's Hospital, Wilmslow Road, Withington, Manchester M20 4BX, U.K Search for other works by this author on: Oxford Academic Google Scholar N.M. Craven N.M. Craven Department of Dermatology, Burnley General Hospital, Burnley BB10 2PQ, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 4, 1 April 2002, Pages 700–703, https://doi.org/10.1046/j.1365-2133.2002.04542.x Published: 01 April 2002 Article history Accepted: 19 August 2001 Published: 01 April 2002
A Survey of Attitudes of Chairmen of Departments of Psychiatry Toward Community Mental Health
Authors: ANTHONY F. PANZETTA, R. BRUCE SLOANE, HARRIET ARONSON
Journal: American Journal of Psychiatry (1973)

The authors conducted a survey of chairmen of departments of psychiatry to determine their attitudes toward community mental health and the extent of their departments' involvement in community psychiatry. Among their findings were: a majority of departments had some association with a community mental health center (CMHC); the larger the department, the more likely such an association; a majority of departments offered training in community psychiatry to their residents; significant research in community mental health was carried on by a minority of respondents; most chairmen had a favorable attitude toward community mental health; and a majority of chairmen were congenial to having a CMHC within their departments.
ABC of clinical haematology: The future of haematology, molecular biology, and gene therapy
Authors: A. K Fielding, S. Ager, S. J Russell
Journal: BMJ (1997)

This article will assess the impact of advances in science and technology on the practice of haematology and attempt to predict how haematology will change further over the next 10 to 15 years.The major advances in scientific thought and technological development that have already changed the practice of modern haematology are likely to affect both laboratory diagnosis and treatment in the future.This article will address three specific area of haematology-anaemia, haemophilia, and leukaemia-and explain how important innovations could be expected to change clinical practice in these areas.The article begins, however, with an overview of gene therapy, which, although currently some way from curing haematological diseases, is likely to have a role in most areas of haematological practice in the future.Both diagnostically and therapeutically, the identification of the molecular pathology of the underlying disorder will continue to steer the future, but the ability to make more accurate diagnoses has not yet resulted in improved treatment.
(34) Sezary syndrome treated with α-interferon
Authors: N.R. Rowell
Journal: British Journal of Dermatology (1987)

Journal Article (34) Sézary syndrome treated with α‐interferon Get access N.R. Rowell N.R. Rowell The General Infirmary of Leeds. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 84–85, https://doi.org/10.1111/j.1365-2133.1987.tb12074.x Published: 01 June 1987
Elevated Cerebrospinal Fluid Glutamate in Patients With HIV-related Dementia-Reply
Authors: Carlo Ferrarese
Journal: JAMA (1997)

<h3>In Reply.</h3> —Drs Gurwitz and Kloog raise some points regarding possible alternative interpretations of our data. Human immunodeficiency virus—related encephalitis is present in all patients with AIDS-related dementia, and its severity is correlated with the extent of viral infection and degree of dementia.<sup>1</sup>For this reason, we believe that an increased glutamate level in CSF can be directly explained by interaction of viral proteins or factors from virus-infected cells (cytokines, free radicals, and nitric oxide) with glutamate transporters within the central nervous system. The alternative explanation of increased CSF glutamate levels as a reflection of elevated plasma levels appears less likely, for several reasons. Plasma glutamate levels were similarly elevated in AIDS patients with and without dementia,<sup>2</sup>and BBB disruption also may be present in nondemented HIV-positive patients who have normal CSF glutamate levels.<sup>3</sup>Moreover, although glutamate levels are normally 10 times higher in blood than in CSF, in
Prognostic Value of Dobutamine Echocardiography Early After Uncomplicated Acute Myocardial Infarction: A Comparison With Exercise Electrocardiography
Authors: Cosimo A Greco, Alessandro Salustri, Fulvia Seccareccia, Massimo Ciavatti, Fabio Biferali, Carlo Valtorta, Giuseppe Guzzardi, Mario Falcone, Antonio Palamara
Journal: Journal of the American College of Cardiology (1997)
Reform of the clinical excellence awards scheme: why are we waiting?
Authors: Karen Bloor, Alan Maynard
Journal: Journal of the Royal Society of Medicine (2012)

In July 2011 the Review Body on Doctors' and Dentists' Remuneration submitted to the department of health its review of compensation levels, incentives and the clinical excellence and distinction award schemes for NHS consultants. Ministers are still considering its recommendations, and the report remains unpublished. In anticipation of its eventual publication, we would like to rekindle debate on appropriate compensation and incentives for NHS consultants.
Make countries' health spending easier to compare, says OECD
Authors: S. Arie
Journal: BMJ (2011)

The Organisation for Economic Co-operation and Development is urging all countries to meet a global standard in the way they account for their health service spending.

In October the OECD, in collaboration with Eurostat (the European Commission’s statistics directorate general) and the World Health Organization, published what it describes as a “monster of a manual” called A System of Health Accounts . It provides detailed guidelines to help countries develop better accounts that policy makers can use to quickly extract useful data.

“One of the weird things in health is that there are a lot of data …
The Evolution of Hospitals in Britain
Authors: Lester S. King
Journal: JAMA (1965)

The changing patterns in medical practice and in medical education confer increased importance on today's hospitals. It is especially appropriate, therefore, and especially welcome, to have a book which broadly discusses the evolution of hospitals. Many separate institutions have published individual well-documented histories, but there has been a great need for an overall survey of the role of hospitals in medicine.  The present volume originated in a symposium, held in September, 1962, as the Third British Congress on the History of Medicine and Pharmacy. It gives us, so to speak, both a longitudinal and a crosssectional approach. The initial chapters each discuss a specific time span. Other papers analyze the various specialty hospitals—those institutions restricted to specific groups of patients, whether pregnant women, children, the mentally ill, or naval or military personnel. The final group of chapters discusses broader aspects, concerned with particular topics such as specialization; the hospital as
Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis.
Authors: J M McLenachan, J K Williams, R D Fish, P Ganz, A P Selwyn
Journal: Circulation (1991)

BACKGROUND Healthy arteries exhibit endothelium-dependent dilation in response to both local acetylcholine and increased blood flow. In humans, clinically overt coronary artery disease is characterized by loss of dilation to both acetylcholine and blood flow. The temporal relation, however, between functional abnormalities of the endothelium and the development of atherosclerosis has not been established. METHODS AND RESULTS We examined endothelial vasodilator function in vivo at an early stage of the development of atherosclerosis. Two groups of seven Macaca fascicularis monkeys were studied; one group was fed a high cholesterol diet (0.73-1.0 mg cholesterol per calorie) for 11 months. Cholesterol feeding was associated with increased plasma cholesterol levels and with intimal thickening of the iliac arteries but with no reduction in luminal diameter. Endothelium-dependent vasomotor responses of the iliac arteries were then examined in vivo by quantitative contrast angiography. Acetylcholine produced significant dilation in the controls but paradoxical constriction in the group with early atherosclerosis (+9.0 +/- 3.2% versus -5.3 +/- 5.4%, p less than 0.05). In response to a twofold increase in blood flow achieved by administering adenosine distal to the arterial segment under examination, the controls again dilated, whereas the atherosclerotic group failed to dilate (+ 11.6 +/- 2.1% versus + 0.5 +/- 2.4%, p less than 0.05). Both groups, however, were able to dilate, and dilated equally, to the nonendothelium-dependent agent nitroglycerin (+ 13.7 +/- 4.8% versus + 19.1 +/- 4.3%, NS). CONCLUSIONS Endothelium-dependent vasodilation in response to both acetylcholine and increased blood flow may be lost early in the course of developing atherosclerosis before the appearance of stenosing and occlusive disease.
CORRELATION OF FRACTIONAL SHORTENING MEASURED FROM ECHO AND Tc-99m SESTAMIBI CARDIAC IMAGES
Authors: P. R. Tirupattur, G. D. Arora, M. S. Bakshi, J. A. Gerardo, P. E. Barnhill, P. M. Mehta, A. Movahed
Journal: Clinical Nuclear Medicine (1994)

Tirupattur, P. R.; Arora, G. D.; Bakshi, M. S.; Gerardo, J. A.; Barnhill, P. E.; Mehta, P. M.; Movahed, A. Author Information
Abstract 2476: Regular Physical Activity Prevents the Development of Left Ventricular Hypertrophy in Young Stage 1 Hypertensive Subjects: Results of the Harvest Study
Authors: Lucio Mos, Pier Alberto Visentin, Paolo Mormino, Francesca Dorigatti, Olga Vriz, Veronica Dusi, Paolo Palatini
Journal: Circulation (2008)

A beneficial effect of physical activity on left ventricular mass( LVM) in the short term has been described in hypertension. Aim of this study was to investigate the long-term effect of regular physical activity on development of left ventricular hypertrophy (LVH) in a cohort of young hypertensive subjects. We studied 454 participants (317 men, mean age 33±8 years) without LVH at baseline whose physical activity status was consistent throughout the follow-up. BP was 146±11/94±5 mm Hg at baseline and 141±/90±8 mmHg after 3 months of non-pharmacological measures. Subjects were divided into 3 categories of physical activity (sedentary, n=281;leisure-time activities, n=140; competitive sports, n=33). Patients were seen every six months until they developed hypertension. Echocardiographic LVM was measured at entry, every 5 years, and/or at the time of hypertension development. Active subjects were younger (31±8 versus 34±8 years, p=.000) and leaner (24.4±3.0 vs 25.2±3.7 Kg/m2, p=.006) than sedentary ones, and were more frequently male (45% versus 22%, p=.000). During a median follow-up of 8.2 years, 32 subjects(7.3%) developed LVH (sedentary=10.3%, leisure-time activities=2.1%, competitive sports= 0%, p=.002). In a logistic regression, physically active groups combined (n=173) were less likely to develop LVH than the sedentary group with a crude OR=0.16 (CI, 0.05– 0.55). After controlling for sex, age, family history for hypertension, body weight, smoking, alcohol and coffee use, blood pressure, LVM, and follow-up time, the OR was 0.22 (CI, 0.06 – 0.77). BP declined over time in physically active subjects (−5.1±17.0/−0.5±10.2 mmHg) and slightly increased in sedentary ones (0.0±15.3/0.9±9.7 mmHg, adjusted p versus active=0.04/0.06). Inclusion of changes in BP over time into the logistic model slightly decreased the strength of the association between physical activity status and LVH development (OR=0.24,CI, 0.07– 0.85). Regular physical activity prevents the development of LVH in young stage 1 hypertensive subjects. Leisure-time and competitive sports activities seem to have both a beneficial effect on LVM. This effect is only partially dependent on the reduction in BP caused by exercise.
Experts Hope Team Approach Improve the Quality of Rape Exams
Authors: Rebecca Voelker
Journal: JAMA (1996)

ALL IT TOOK was one case. After an older woman from a prominent family was raped in 1989 in northern San Diego County, California, her family was outraged at spending hours in a hospital emergency department, only to be told she could not be examined there. The woman had to find another hospital; her case found its way into the media spotlight. The ensuing controversy prompted the county's Department of Health Services and Board of Supervisors to investigate. Among their findings: rape survivors generally spent 4 to 6 hours waiting for an examination that took another 2 to 3 hours; responses of police, medical professionals, and advocates for victims of reported rapes weren't coordinated; and the collection of evidence during the sexual assault examination often was inadequate. "There was no standardized protocol," says Diana Faugno, RN, a forensic nurse at Palomar Pomerado Health System in Escondido, Calif. "If you were