tbuckley/cabot-search huggingface dataset:
Incidence of allergic contact sensitization in Danish adults between 1990 and 1998; the Copenhagen Allergy Study, Denmark
Authors: N.H. Nielsen, A. Linneberg, T. MennE, F. Madsen, L. FrOlund, A. Dirksen, T. JOrgensen
Journal: British Journal of Dermatology (2002)

Studies of incidence of contact allergy in a general population have not been reported. Data from incidence studies may support and direct strategies for prevention of contact allergy and allergic contact dermatitis.To study the incidence of contact allergy and evaluate risk factors for developing contact allergy in an adult general population sample.In 1990 a random sample of 567 persons of the 15-69-year-old population living in the western part of Copenhagen County (Denmark) was patch tested in a cross-sectional study. In 1998 a follow-up study was performed. Of 540 invited, 365 (68%) were patch tested again.In the follow-up study, 37 persons (12%) of the 313 patch-test-negative persons in 1990 had developed one or more positive patch tests (incident contact allergy). Twenty cases (6%) of incident nickel allergy and 25 cases (8%) of incident contact allergy to one or more haptens other than nickel were found. The data indicate that female sex, young age and ear piercing (before 1990) were risk factors for developing nickel allergy. Between 1990 and 1998 metal contact dermatitis was reported in seven women with incident nickel allergy. Six of these women had bought the eliciting item in Denmark before 1995, when vigorous control of the Danish nickel legislation was introduced.We found a considerable number of incident cases of contact allergy in the adult population. The results of the study support the actions taken to restrict the use of the allergens most frequently encountered, and to increase the labelling demands to products intended for prolonged contact with the skin or a combined action.
Increased expression of promatrix metalloproteinase-9 and neutrophil elastase in canine dilated cardiomyopathy
Authors: S Gilbert
Journal: Cardiovascular Research (1997)

Canine dilated cardiomyopathy, commonly affecting Doberman pinschers, results in extracellular matrix remodelling within the myocardium. The aim of this study was to examine the proteolytic activity in myocardium from Doberman pinschers with dilated cardiomyopathy.Samples of myocardium, obtained rapidly post mortem from the left ventricular free wall of Dobermans with dilated cardiomyopathy, clinically normal Dobermans and control dogs (non-Dobermans), were examined for proteolytic activity using substrate gel zymography. Gels were analysed by scanning densitometry.Promatrix metalloproteinase-9 activity was significantly increased in all Doberman myocardium when compared to controls. A significant increase in an enzyme, identified to be neutrophil elastase by inhibition of its activity by Elastatinal and Western blotting, was also detected in all Dobermans when compared to controls.The results indicate that promatrix metalloproteinase-9 and neutrophil elastase, both of which are implicated in inflammatory responses, are present in significantly elevated levels in Doberman dilated cardiomyopathy and are raised in clinically normal Dobermans. Both proteolytic enzymes degrade a wide variety of connective tissue components and thus the increased levels found may play an important role in the structural remodelling seen in the myocardium and subsequent heart failure. Increased proteolytic enzyme levels in clinically normal Dobermans may be indicative of the predisposition of the breed to dilated cardiomyopathy.
Biological Weapons Proliferation Arouses United States and International Concern
Authors: Phil Gunby
Journal: JAMA (1989)

BIOLOGICAL WEAPONS are being much discussed in Congress these days, as well as around the world, and the US House of Representatives in particular has been considering two related resolutions. Representative Wayne Owens (D-Utah) is the sponsor of both the recently reintroduced resolutions. (More detailed discussions are found elsewhere in this issue.) <h3>Recent Days' Debate</h3> One, which has been under study by the House Committee on Energy and Commerce, would require that "all federal research, development, testing, and evaluation of the medical aspects of the use of biological agents in the development of defenses against biological warfare" be conducted through the National Institutes of Health, whose main campus is in Bethesda, Md. The other, in its original form, would have required the Secretary of Defense to publish annually in the<i>Federal Register</i>the biological agents being used in defense research. Members of the Committee on Armed Services changed that requirement
Role of Brain Disease in Riots and Urban Violence
Authors: Seymour L. Pollack
Journal: JAMA (1967)

ABSTRACT To the Editor:— The discussion of V. H. Mark, MD et al (201:895, 1967) of the Role of Brain Disease in Riots and Urban Violence is very disturbing. The implication is that brain dysfunction in selected instances may be the cause of the destructive behavior in riots. It is implied that there is a greater incidence of brain dysfunction related to focal lesion in a group of rioters as contrasted with a group of nonrioters in a slum area.Over the years I have seen an enormous number of patients with brain disorders of all types who exhibited no violent or assaultive behavior. More specifically I have seen large numbers of patients with the type of focal lesion described by the writers of this letter. These patients have not exhibited this type of assaultive behavior. I will grant that I have occasionally seen a patient with this type of
A comparative serological and molecular study of linear IgA disease and dermatitis herpetiformis
Authors: J.A. SACHS, J. LEONARD, J. AWAD, D. MCLOSKEY, H. FESTENSTEIN, G.A. HITMAN, L. FRY
Journal: British Journal of Dermatology (1988)

The class I and class II HLA serologically defined antigens and DQα and DXα restriction fragment length polymorphism (RFLP) in 23 patients with linear IgA disease (LAD) were determined and their frequencies compared with those in a group of patients with dermatitis herpetiformis (DH) and healthy controls. In LAD there was a significant increase in HLA‐B8 and DR3 and a larger increase in the DQw1‐DR2/DRw6 related DQα 6.2 kb and 6.8 kb RFLP. In DH there was a significantly increased frequency of HLA‐A1, B8, DR3, and DQw2 with a concomitant increase in the DR3‐DQw2 related DQα 4.6 kb RFLP. The difference in DR3 frequencies and the increased frequency of DQw1 rather than DQw2 in LAD indicates that different susceptibility genes operate in the two diseases.
Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation
Authors: Gerald S. Horan, Susan Wood, Victor Ona, Dan Jun Li, Matvey E. Lukashev, Paul H. Weinreb, Kenneth J. Simon, Kyungmin Hahm, Normand E. Allaire, Nicola J. Rinaldi, Jaya Goyal, Carol A. Feghali-Bostwick, Eric L. Matteson, Carl O'Hara, Robert Lafyatis, Gerald S. Davis, Xiaozhu Huang, Dean Sheppard, Shelia M. Violette
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Transforming growth factor (TGF)-beta has a central role in driving many of the pathological processes that characterize pulmonary fibrosis. Inhibition of the integrin alpha(v)beta6, a key activator of TGF-beta in lung, is an attractive therapeutic strategy, as it may be possible to inhibit TGF-beta at sites of alpha(v)beta6 up-regulation without affecting other homeostatic roles of TGF-beta.To analyze the expression of alpha(v)beta6 in human pulmonary fibrosis, and to functionally test the efficacy of therapeutic inhibition of alpha(v)beta6-mediated TGF-beta activation in murine bleomycin-induced pulmonary fibrosis.Lung biopsies from patients with a diagnosis of systemic sclerosis or idiopathic pulmonary fibrosis were stained for alpha(v)beta6 expression. A range of concentrations of a monoclonal antibody that blocks alpha(v)beta6-mediated TGF-beta activation was evaluated in murine bleomycin-induced lung fibrosis.Alpha(v)beta6 is overexpressed in human lung fibrosis within pneumocytes lining the alveolar ducts and alveoli. In the bleomycin model, alpha(v)beta6 antibody was effective in blocking pulmonary fibrosis. At high doses, there was increased expression of markers of inflammation and macrophage activation, consistent with the effects of TGF-beta inhibition in the lung. Low doses of antibody attenuated collagen expression without increasing alveolar inflammatory cell populations or macrophage activation markers.Partial inhibition of TGF-beta using alpha(v)beta6 integrin antibodies is effective in blocking murine pulmonary fibrosis without exacerbating inflammation. In addition, the elevated expression of alpha(v)beta6, an activator of the fibrogenic cytokine, TGF-beta, in human pulmonary fibrosis suggests that alpha(v)beta6 monoclonal antibodies could represent a promising new therapeutic strategy for treating pulmonary fibrosis.
FOXD3 Is a Mutant B-RAF–Regulated Inhibitor of G1-S Progression in Melanoma Cells
Authors: Ethan V. Abel, Andrew E. Aplin
Journal: Cancer Research (2010)

Abstract The forkhead box transcription factor FOXD3 is a stemness factor that prevents the production of melanocyte progenitors from the developing neural crest; however, its role in human cancers is not known. Transformation of melanocytes gives rise to melanoma. In two thirds of melanomas, the serine/threonine kinase B-RAF is mutated to a constitutively active form. Here, we show that FOXD3 levels are upregulated following attenuation of B-RAF and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK) signaling in mutant B-RAF harboring human melanoma cells. This effect was selective because FOXD3 was not upregulated following MEK inhibition in wild-type B-RAF melanoma cells and mutant B-RAF thyroid carcinoma cells. Ectopic FOXD3 expression potently inhibited melanoma cell growth without altering mutant B-RAF activation of ERK1/2. Inhibition of cell growth was due to a potent G1 cell cycle arrest and was associated with p53-dependent upregulation of p21Cip1. FOXD3-induced cell cycle arrest was prevented by p53 depletion and, to a lesser extent, p21Cip1 depletion. These studies show that FOXD3 is suppressed by B-RAF, uncover a novel role and mechanism for FOXD3 as a negative cell cycle regulator, and have implications for the repression of melanocytic lineage cells. Cancer Res; 70(7); 2891–900
Interesting Cancer Case
Authors: J. H. S. Geggie
Journal: BMJ (1950)

<i>BACKGROUND AND PURPOSE:</i> Presurgical sensorimotor mapping with functional MR imaging is gaining acceptance in clinical practice; however, to our knowledge, its therapeutic efficacy has not been assessed in a sizable group of patients. Our goal was to identify how preoperative sensorimotor functional studies were used to guide the treatment of neuro-oncologic and epilepsy surgery patients. <i>METHODS:</i> We retrospectively reviewed the medical records of 46 patients who had undergone preoperative sensorimotor functional MR imaging to document how often and in what ways the imaging studies had influenced their management. Clinical management decisions were grouped into three categories: for assessing the feasibility of surgical resection, for surgical planning, and for selecting patients for invasive functional mapping procedures. <i>RESULTS:</i> Functional MR imaging studies successfully identified the functional central sulcus ipsilateral to the abnormality in 32 of the 46 patients, and these 32 patients are the focus of this report. In epilepsy surgery candidates, the functional MR imaging results were used to determine in part the feasibility of a proposed surgical resection in 70% of patients, to aid in surgical planning in 43%, and to select patients for invasive surgical functional mapping in 52%. In tumor patients, the functional MR imaging results were used to determine in part the feasibility of surgical resection in 55%, to aid in surgical planning in 22%, and to select patients for invasive surgical functional mapping in 78%. Overall, functional MR imaging studies were used in one or more of the three clinical decision-making categories in 89% of tumor patients and 91% of epilepsy surgery patients. <i>CONCLUSION:</i> Preoperative functional MR imaging is useful to clinicians at three key stages in the preoperative clinical management paradigm of a substantial percentage of patients who are being considered for resective tumor or epilepsy surgery.
Simultaneous Demonstration of Photopenic ("Cold") and Osteoblastic ("Hot") Skull Metastases in a Patient with Neuroblastoma
Authors: I GARTY, A KOREN
Journal: Clinical Nuclear Medicine (1985)

A 5-year-old boy with advanced metastatic neuroblastoma is presented. The unexpected appearance of "cold" (photopenic) and "hot" (osteoblastic) skull metastases, demonstrated in two different views of the same Tc-99m MDP bone scintigram, is illustrated.
The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function
Authors: Zhang-Qi Feng, Xuehui Chu, Ning-Ping Huang, Tao Wang, Yichun Wang, Xiaolei Shi, Yitao Ding, Zhong-Ze Gu
Journal: Biomaterials (2009)
Cimetidine and Gastric Carcinoma
Authors: MARTIN H. POLESKI
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 May 1983Cimetidine and Gastric CarcinomaMARTIN H. POLESKI, M.D.MARTIN H. POLESKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-673_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The second part of Freston's review on Cimetidine (1) does not mention an important point relevant to the gastric carcinoma issue. There is some clinical evidence that a decade or two after surgery for duodenal ulcer disease, there may be an increased incidence of carcinoma in the gastric stump (2, 3). The studies by Reed and associates, as pointed out by Freston, show a positive correlation between gastric pH and increasedN-nitrosamine and nitrate levels in gastric juice (4). These studies also show that Cimetidine therapy and vagotomy equally raiseN-nitrosamine levels to a small extent, but...References1. FRESTON J. Cimetidine: II. Adverse reactions and patterns of use. Ann Intern Med. 1982;97:728-34. LinkGoogle Scholar2. WEISSMANWINAWER GS. Gastric carcinoma after gastric surgery. Gastroenterology. 1982;83:493-4. Google Scholar3. KLARFELDRESNICK JG. Gastric remnant carcinoma. Cancer. 1979;44:1129-33. CrossrefMedlineGoogle Scholar4. REEDSMITHHAINESHOUSEWALTERS PPKFC. Effect of Cimetidine on gastric juice N-nitroasmine concentrations. Lancet. 1981;2:553-6. CrossrefMedlineGoogle Scholar5. DEVENEYFREEMANWAY CHW. Experimental gastric carcinogenesis in the rat. Am J Surg. 1980;139:49-54. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARTIN H. POLESKI, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1983Volume 98, Issue 5_Part_1Page: 673-673KeywordsDuodenal ulcersNitratesSurgeryVagotomy ePublished: 1 December 2008 Issue Published: 1 May 1983 PDF downloadLoading ...
Points from letters: NHS economies
Authors: A. Muir
Journal: BMJ (1975)

October, p 25) is not alone.At the inception of the NHS in 1948 I was an assistant in general practice and lived above the surgery in a traffic-congested area.At that time I managed my rounds quite easily on a bicycle.Unfortunately both your clientele and your colleagues come to regard you as an outsider, which adds to your emotional burden.The car becomes your
Hunterian Oration on HERO WORSHIP IN SURGERY
Authors: E. W. H. Groves
Journal: BMJ (1930)

B"Olle comfort is, that Great Men, taken' up in profitable company.We cannot look, however impe a great, man, wiuhout gaininig somethinig by hlim Hc70 olforship.Wai,lhaveimet to-dayonl the birthdlay festiv Hulliter, one of the greatesthleroes of Engl Conisiderablynmore than a century' v has elaps( 1814, this Oratioin w1as fouinded by Hunter'sex
Extended Indications for Skin Conserving of the Nipple Areola Complex during Subcutaneous Mastektomie.
Authors: M. Niemeyer, B. Rainer, M. Kiechle, D. Paepke, B. Plattner, S. Paepke
Journal: Cancer Research (2009)

Abstract Background: Conventional breast cancer surgery in case of a non breast conserving procedure still includes the routine excision of the nipple areolar complex (NAC) optional followed by nipple reconstruction. Numerous authors consider multiple predictive factors to decide whether the Nipple Areola Complex (NAC) can be conserved or not during mastectomy. These are: tumour-nipple distance, tumour size, axillary lymph-node status and lymph vascular invasion. Thus only a very limited percentage of patients can keep their NAC.If the breast gland tissue and all galactophoric ducts can be separated completely from the NAC during subcutaneous mastectomy (SCM), conservation of the NAC is feasible even in large, central and retroareola tumours.Patients and methods: (www.clinicaltrials.com ID: NCT00641628) From July 2003 to Mai 2006 we performed 109 SCMs on 96 patients. 94 of these breasts showed indications for modified radical mastectomy (MRM) or ablatio simplex. 78 due to invasive carcinoma (MRM indication) and 16 of them had extensive ductal carcinoma in situ (DCIS), (indication for simple ablation). At least 33 of the breasts had malignancy underneath the skin within the areola margin (central located tumours). After dissection of the complete mammary gland tissue, the skin envelope with the areola is folded inside out an all galactophoric ducts and any subjacent tissue on the areola base are precisely dissected under the surgeons' visual control. Of this skin-closest retroareola tissue, frozen sections and HE-histopathologic examinations are requested to decide whether the NAC can be preserved or not.Results: We found the Need to dissect the NAC in 13 of 109 breasts (12%), altering the procedure to a skin sparing mastectomy (SSM). Necrosis of the NAC which had to be subjected to surgical intervention occurred in only one of the conserved 96. After a follow-up of 20-54, median 34 months no recurrence within the NAC was observed. One local recurrence on the thoracic wall and one axillary recurrence were detected. 2 of 96 patients developed distant metastases. One death was recorded. Occasionally, partial necrosis of the nipple occurred, leaving a depigmentation of the skin but maintaining a good or excellent cosmetic result in most cases. Necrosis of the NAC which had to be subjected to surgical intervention occurred in only one patient.Conclusion: SCM, including NAC conservation, may be performed according to MRM indications if an intraoperatively frozen section (and the corresponding HE-histopathology) of the NAC closest tissue is free of tumour. The remaining contraindications for SCM are: extensive tumour involvement of the skin, inflammatory breast cancer and clinical suspicious nipple. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3107.
Primary Myocardial Disease: Clinical Features and Hemodynamic Alterations.
Authors: Cloyd L. Dye
Journal: Annals of Internal Medicine (1964)

s1 February 1964Primary Myocardial Disease: Clinical Features and Hemodynamic Alterations.Cloyd L. Dye, M.D., W. J. Daly, M.D., J. C. Lowe, M.D., Roy H. Behnke, M.D., F.A.C.P., P. D. Genovese, M.D., F.A.C.P., D. Rosenbaum, M.D.Cloyd L. Dye, M.D.Search for more papers by this author, W. J. Daly, M.D.Search for more papers by this author, J. C. Lowe, M.D.Search for more papers by this author, Roy H. Behnke, M.D., F.A.C.P.Search for more papers by this author, P. D. Genovese, M.D., F.A.C.P.Search for more papers by this author, D. Rosenbaum, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-316_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThirty-two males, average age 43 years, with idiopathic cardiomegaly and signs and symptoms of heart failure were studied. Fourteen were Negroes (hospital population, 18% Negro). Twenty-one drank ethanol in excess.The electrocardiogram was invariably abnormal, showing left ventricular hypertrophy, intraventricular or bundle branch block, low voltage, or T wave changes. Atrial fibrillation and premature ventricular systoles were the commonest arrhythmias. The chest roentgenogram frequently suggested pericardial effusion.Patients usually survived the first bout of heart failure, but often died during recurrent episodes as did 12 in this series. Sudden death was common. Peripheral embolization was recognized in 37%. Right and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, Indiana PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 316-316KeywordsArrhythmiaAtrial fibrillationElectrocardiographyEthanolHeart failureHemodynamicsLeft ventricular hypertrophySigns and symptomsSystoleThorax ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
Effect of emepronium bromide on lower oesophageal sphincter.
Authors: O J Siemssen, J T Andersen, H H Meyhoff, J Nordling, S Walter
Journal: BMJ (1981)

Comparative risks of rhesus autoimmunisation in two different methods of mid-trimester abortionThe introduction of anti-D immunoglobulin has greatly reduced the incidence of rhesus haemolytic disease, though cases still occur.'Autoimmunisation after spontaneous or induced abortion is an important factor and can probably be prevented: anti-D immuno- globulin is not always given to Rh-negative women.2Autoimmunisa-
Fetal intracardiac transfusions in patients with severe rhesus isoimmunisation
Authors: M. Westgren, A. Selbing, M. Stangenberg
Journal: BMJ (1988)

Six patients with pregnancies of 19-31 weeks' duration showing evidence of erythroblastosis fetalis were treated with 25 fetal intracardiac blood transfusions. Complications related to the procedure occurred on five occasions in three patients. In two of the six patients the fetus died, but it was unlikely that death was related to the intracardiac transfusions. Fetal intracardiac blood transfusion may result in potentially severe complications but offers an alternative when transfusion cannot be performed into the umbilical cord.