Lung Transplantation—Past, Present, and Future
Authors: EUGENE D. ROBIN
Journal: Annals of Internal Medicine (1966)

Editorials1 November 1966Lung Transplantation—Past, Present, and FutureEUGENE D. ROBIN, M.D., CARROLL E. CROSS, M.D.EUGENE D. ROBIN, M.D.Search for more papers by this author, CARROLL E. CROSS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1138 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany forms of lung disease are associated with irreversible anatomical changes. Medical therapy may palliate or decrease the rate of progression; it is seldom curative. It is not surprising that the possibility of pulmonary transplant as a therapeutic measure has been considered by many physicians. This editorial will consider, like the three ghosts in Dickens' "Christmas Carol" (1), Transplant Past, Transplant Present, and Transplant Future, reviewing the history of lung transplantation, outlining the present state of knowledge, and attempting to outline future prospects. Since this is an editorial rather than a review, the treatment will not be exhaustive and the...References1. DICKENS C: A Christmas Carol. Chapman and Hall, London, 1843. Google Scholar2. GUTHRIE CC: Bull. Hopkins Hosp. 18: 25, 1907, quoted in Blood Vessel Surgery and Its Applications (a reprint). University of Pittsburgh Press, Pittsburgh, 1959. Google Scholar3. DEMIKHOV VP: Experimental Transplantation of Vital Organs. Consultants Bureau Enterprises, Inc., New York, 1962. Google Scholar4. STAUDACHERBELLINAZZOPULIN VEPA: Primi rilievi su tentativi di reimpianti autoplastici e di trapianti omoplastici di lobi polmonari. Chirurgia (Milano) 5: 223, 1950. Google Scholar5. LANARIMOLINSCROXATTO AMO: Homoinjertos de pulmon en perros: tecnica y resultados funcionales y anatomicos. Mediana (B. Air.) 11: 12, 1951. MedlineGoogle Scholar6. LANARICROXATTOMOLINS AOM: Homogreffe et autogreffe du poumon chez le chien. Poumon Coeur 12: 67, 1956. MedlineGoogle Scholar7. JUVENELLEClTRETWlLESSTEWART AACCEJD: Pneumonectomy with replantation of the lung in the dog for physiologic study. J. Thorac. Surg. 21: 111, 1951. CrossrefMedlineGoogle Scholar8. PORTINRASMUSSENSTEWARTANDERSEN BAGLJDMN: Physiologic and anatomic studies thirty-five months after successful replantation of the lung. J. Thorac. Cardiov. Surg. 39: 380, 1960. CrossrefMedlineGoogle Scholar9. NEPTUNEWELLERBAILEY WBRCP: Experimental lung transplantation. J. Thorac. Surg. 26: 275, 1953. CrossrefMedlineGoogle Scholar10. BLUMENSTOCKKAHN DADR: Replantation and transplantation of the canine lung. J. Surg. Res. 1: 40, 1961. CrossrefGoogle Scholar11. BLUMENSTOCKCOLLINSHECHTMANHOSBEINLEMPERTTHOMASFERREBEE DAJAHBDJNEDJW: Lung transplantation in the dog. Ann. N. Y. Acad. Sci. 120: 677, 1964. CrossrefMedlineGoogle Scholar12. HARDYERASLANDALTON JDSML: Autotransplantation and homotransplantation of the lung: further studies. J. Thorac. Cardiov. Surg. 46: 606, 1963. CrossrefMedlineGoogle Scholar13. HARDYERASLANWEBB JDSWR: Transplantation of the lung. Ann. Surg. 160: 440, 1964. CrossrefMedlineGoogle Scholar14. REEMTSMAROGERSLUCASSCHMIDTDAVIS KREJFFEFH: Studies of pulmonary function in transplantation of the canine lung. J. Thorac. Cardiov. Surg. 46: 589, 1963. CrossrefMedlineGoogle Scholar15. YEHELLISONELLISON TJLTRG: Functional evaluation of the autotransplanted lung in the dog. Amer. Rev. Resp. Dis. 86: 791, 1962. MedlineGoogle Scholar16. DAVIESROSSERWEST LGTHLR: Autotransplantation of the lung in sheep. Thorax 20: 481, 1965. CrossrefMedlineGoogle Scholar17. BORRIELICHTER JI: Lung transplantation: technical problems. Thorax 19: 383, 1964. CrossrefMedlineGoogle Scholar18. HAGLINARNAR JJO: Physiologic studies of the baboon living on only the reimplanted lung. Surg. Forum 15: 175, 1964. MedlineGoogle Scholar19. KAHNWILSONTOLBERTSLOAN DRWSJHH: Response of the reimplanted lung to hypoxia. Ann. Thorac. Surg. 1: 97, 1965. CrossrefMedlineGoogle Scholar20. HARDYWEBBDALTONWALKER JDWRMLGR: Lung homotransplantation in man. JAMA 186: 1065, 1963. CrossrefMedlineGoogle Scholar21. MAGOVERNYATES GJAJ: Human homotransplantation of left lung: report of a case. Ann. N. Y. Acad. Sci. 120: 710, 1964. CrossrefMedlineGoogle Scholar22. WHITETANSERANTHONISENWYNANDSPAREBECKLAKEMUNROMACLEAN JJPHNRJEJAMRDDLD: Human lung homotransplantation. Canad. Med. Ass. J. 94: 1199, 1966. MedlineGoogle Scholar23. TRUMMER MJ: Experimental transplantation of the lung. Ann. Thorac. Surg. 1: 203, 1965. CrossrefMedlineGoogle Scholar24. METRAS H: Note preliminaire sur la greffe totale du poumon chez le chien. C. R. Acad. Sci. (Paris) 231: 1176, 1950. Google Scholar25. SLIMYACOUBIANSIMONIANSAHYOUN MSHDSJP: Bilateral reimplantation of canine lungs, anatomical and physiological observations in a long-term survivor. Ann. Thorac. Surg. 1: 755, 1965. CrossrefMedlineGoogle Scholar26. BARNESFLAXBURKEBARR BAMHJFG: Experimental pulmonary homografts in the dog. I. morphological studies. Transplantation 1: 351, 1963. CrossrefMedlineGoogle Scholar27. HILLROWLANDSRIFKIND RBDTD: Infectious pulmonary disease in patients receiving immunosuppressive therapy for organ transplantation. New Eng. J. Med. 271: 1021, 1964. CrossrefMedlineGoogle Scholar28. NIGROEVANSGAGOADAMS SLRHOWE: Altered physiology of the pulmonary vascular bed: a factor in decreased function of the reimplanted lung. Dis. Chest 46: 317, 1964. CrossrefMedlineGoogle Scholar29. SLIMYACOUBIANWILSONRUBEIZGHANDUR-MANYMNEH MSHDJLGAL: Successful bilateral reimplantation of canine lungs. Surgery 55: 676, 1964. MedlineGoogle Scholar30. HAGLINTELANDERMUZZALLKISERSTROBEL JRLREJCCJ: Comparison of lung autotransplantation in the primate and the dog. Surg. Forum 14: 196, 1963. MedlineGoogle Scholar31. WALDHAUSENGIAMMONAKILMANDALY JASTJWWJ: Effect of transplantation of canine lung on pulmonary compliance and surfactant. JAMA 191: 1002 1965. CrossrefMedlineGoogle Scholar32. BLUMENSTOCKCOLLINSTHOMASFERREBEE DAJAEDJW: Homotransplantation of the lung in dogs treated with methotrexate. Surg. Forum 12: 121, 1961. MedlineGoogle Scholar33. BLUMENSTOCKCOLLINSTHOMASFERREBEE DAJAEDJW: Homotransplants of the lung in dogs. Surgery 51: 541, 1962. Google Scholar34. DOSTOEVSKI FM: Crime and Punishment. W. W. Norton Co., New York, 1964. Google Scholar35. MOORE FD: Give and Take, The Development of Tissue Transplantation. W. B. Saunders Co., Philadelphia and London, 1964. Google Scholar36. ELKINTON JR: Moral problems of artificial and transplanted organs. Ann. Intern. Med. 61: 355, 1964. LinkGoogle Scholar37. ROBIN ED: Rapid scientific advances bring new ethical questions. JAMA 189: 624, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Pittsburgh Medical School Pittsburgh, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLung transplantationDiseases Due to Immunologic Reactions in the LungsLung transplantationThe Other Lung 1 November 1966Volume 65, Issue 5Page: 1138-1147KeywordsForecastingLung transplantation Issue Published: 1 November 1966 PDF downloadLoading ...