tbuckley/cabot-search huggingface dataset:
Forearm vascular responsiveness to alpha 1- and alpha 2-adrenoceptor stimulation in patients with congestive heart failure.
Authors: C Indolfi, A Maione, M Volpe, A Rapacciuolo, G Esposito, R Ceravolo, V Rendina, M Condorelli, M Chiariello
Journal: Circulation (1994)

BACKGROUND The alpha-adrenergic component of the sympathetic nervous system plays a major role in the pathophysiology, clinical manifestations, and natural history of human congestive heart failure (CHF). However, the functional integrity of vascular alpha 1- and alpha 2-adrenoceptors in CHF remains to be elucidated. The present study was designed to assess the vascular responsiveness of alpha 1- and alpha 2-adrenoceptors in patients with CHF. METHODS AND RESULTS To evaluate alpha 1- and alpha 2-adrenoceptor responsiveness, we studied the effects of the regional infusion into the brachial artery of increasing doses of phenylephrine (a selective alpha 1-adrenoceptor agonist) and BHT 933 (a selective alpha 2-adrenoceptor agonist) on vascular responses in 12 healthy subjects and in 24 patients with CHF secondary to primary dilated cardiomyopathy or ischemic heart disease. Left ventricular ejection fraction was measured by radionuclide angiography, and forearm blood flow was determined by venous occlusion plethysmography. Phenylephrine reduced forearm blood flow in normal subjects from 5.2 +/- 0.9 to 2.5 +/- 0.6 mL per 100 mL of tissue/min (P &lt; .05) at the highest dose (-50.8 +/- 4.8% versus baseline). A similar vasoconstriction was obtained in patients with CHF (from 3.5 +/- 0.5 to 1.5 +/- 0.2 mL per 100 mL of tissue/min (P &lt; .05) (-58.7 +/- 5.0% versus baseline). The dose-response curves produced by phenylephrine in the two groups were comparable. The highest dose of BHT 933 reduced forearm blood flow in normal subjects from 5.3 +/- 0.9 to 2.3 +/- 0.6 mL per 100 mL of tissue/min (P &lt; .05) (-59.0 +/- 4.9% versus baseline). In patients with CHF, a similar vasoconstriction was obtained (from 4.2 +/- 0.8 to 1.5 +/- 0.3 mL per 100 mL of tissue/min, P &lt; .05, -62.1 +/- 6.5% versus baseline). The dose-response curves produced by BHT 933 also were comparable in the two groups. In patients with CHF, plasma concentrations of norepinephrine were significantly higher than in normal subjects. CONCLUSIONS The results of the present study demonstrate that alpha 1- and alpha 2-adrenoceptor stimulations produced an equivalent vasoconstriction in patients with CHF and in normal subjects. This indicates that the vascular responsiveness to alpha-adrenoceptor agonists may be preserved in the limb vessels of patients with CHF.
933-96 LV Mass Determination by 3D Echocardiography: Initial Clinical Experience and Comparison to Magnetic Resonance Imaging in Patients with Abnormal Ventricular Geometry
Authors: Matthew J. Schnellbaecher, Aasha S. Gopal, Lawrence M. Boxt, Jose Katz, Kathleen Reagan, Zhanqing Shen, Peter M. Sapin, Olakunle O. Akinboboye, Andrew M. Keller, Donald L. King
Journal: Journal of the American College of Cardiology (1995)
Repair of UV Light-Induced DNA Damage and Risk of Cutaneous Malignant Melanoma
Authors: Q. Wei, J. E. Lee, J. E. Gershenwald, M. I. Ross, P. F. Mansfield, S. S. Strom, L.-E Wang, Z. Guo, Y. Qiao, C. I. Amos, M. R. Spitz, M. Duvic
Journal: JNCI Journal of the National Cancer Institute (2003)

Background: The mechanism underlying the role of UV light exposure from sunlight in the etiology of cutaneous malignant melanoma (CMM) is unclear. Patients with xeroderma pigmentosum, a disease characterized by severe sensitivity to UV radiation and a defect in nucleotide excision repair, have a high incidence of CMM, which suggests that DNA repair capacity (DRC) plays a role in sunlight-induced CMM in the general population as well. Methods: We conducted a hospital-based case–control study of DRC and CMM among 312 non-Hispanic white CMM patients who had no prior chemotherapy or radiation therapy, and 324 cancer-free control subjects who were frequency-matched to case patients on age, sex, and ethnicity. Information on demographic variables, risk factors, and tumor characteristics was obtained from questionnaires and medical records. We used the host-cell reactivation assay to measure the DRC in study subjects' lymphocytes. All statistical tests were two sided. Results: Case patients had a 19% lower mean (± standard deviation [SD]) DRC (8.5 ± 3.4%) than control subjects (10.5 ± 5.1%), a statistically significant difference (P<.001). DRC that was at or below the median value (i.e., 9.4%) in control subjects was associated with increased risk for CMM after adjustment for age, sex, and other covariates (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.45 to 2.82). We observed a dose–response relationship between decreased DRC and increased risk of CMM (Ptrend<.001). Patients with tumors on sun-exposed skin had statistically significantly lower DRC than patients with tumors on unexposed skin (8.2 ± 3.3% versus 9.5 ± 3.5%; P = .004). Conclusions: Reduced DRC is an independent risk factor for CMM and may contribute to susceptibility to sunlight-induced CMM among the general population.
Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron
Authors: Mohamed Ramez, Marcel Blot-Chabaud, Françoise Cluzeaud, Sumita Chanan, Michael Patterson, Loren D. Walensky, Shirin Marfatia, Anthony J. Baines, Joel A. Chasis, John G. Conboy, Narla Mohandas, Philippe Gascard
Journal: Kidney International (2003)
An innate language faculty needs neither modularity nor localization
Authors: Derek Bickerton
Journal: Behavioral and Brain Sciences (1996)

Abstract Müller misconstrues autonomy to mean strict locality of brain function, something quite different from the functional autonomy that linguists claim. Similarly, he misperceives the interaction of learned and innate components hypothesized in current generative models. Evidence from sign languages, Creole languages, and neurological studies of rare forms of aphasia also argues against his conclusions.
Serum Viscosity and Hyperviscosity Syndrome in IgG Multiple Myeloma
Authors: W. PRUZANSKl
Journal: Annals of Internal Medicine (1972)

Ten patients with IgG multiple myeloma and hyperviscosity were investigated. They represented 4.2% of 238 patients with IgG myeloma and 22% of 46 patients with IgG M components present in the serum in concentration above 5.0 g/100 ml. The severity of the hyperviscosity syndrome was not directly related to the serum viscosity; each patient responded individually to hyperviscosity. No absolute correlation was found between the viscosities measured at the low and the high shear rate and the absolute viscosity taken at 37 °C or the relative viscosity taken at 22 °C. There was no relationship of the light chain type of M component to the hyperviscosity. Remarkable correlation was noted between the positivity of Sia test and the hyperviscosity properties of the serums. Sia precipitates were composed of an IgG M component. Cryoprecipitation and a tendency to form high-molecular-weight aggregates have also been noted among IgG M components causing hyperviscosity.
Association between prolonged dietary vitamin D deficiency and autonomous hyperparathyroidism.
Authors: A. H. Sultan, F. E. Bruckner, J. B. Eastwood
Journal: BMJ (1989)

Biochemical changes in parathyroidectomy / Ate describe two Asian women with dietary osteo- malacia whose parathyroid overactivity persisted despite treatment with vitamin D., RE Case reports CASE 1A 33 year old vegetarian Indian woman, who had r lived in Britain for nine years, presented with a two year history of bone pain.For six weeks she had had difficulty in climbing stairs.There was tenderness over the spine and right lower ribs.The results of tests of renal and intestinal function were normal.Her albumin concentration was 36 g/l; calcium 2-48 mmol/l; phosphate 0 4 mmol/l (normal 0 8-1 45); alkaline phosphatase 840 IU/l (normal <100); and 25-hydroxy vitamin D 8 nmol/l (normal 20-100).Skeletal x ray pictures were normal.An isotopic bone scan showed increased uptake in the hips, thoracic spine, and ribs.Dietary osteomalacia was diagnosed.In November 1983 she started taking oral ergocalciferol.Her symptoms improved rapidly, and her alkaline phosphatase activity fell to normal over 16 months (figure).Her plasma calcium concen- two Asian women presenting with dietary osteomalacia.Arrows indicate
SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
Authors: Hilmar Quentmeier, Björn Schneider, Sonja Röhrs, Julia Romani, Margarete Zaborski, Roderick AF MacLeod, Hans G Drexler
Journal: Journal of Hematology & Oncology (2009)

SET-NUP214 fusion resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) has recently been described in T-cell acute lymphoblastic leukemia (T-ALL) and in one case of acute myeloid leukemia (AML). The fusion protein appears to promote elevated expression of HOXA cluster genes in T-ALL and may contribute to the pathogenesis of the disease. We screened a panel of ALL and AML cell lines for SET-NUP214 expression to find model systems that might help to elucidate the cellular function of this fusion gene.Of 141 human leukemia/lymphoma cell lines tested, only the T-ALL cell line LOUCY and the AML cell line MEGAL expressed the SET(TAF-Ibeta)-NUP214 fusion gene transcript. RT-PCR analysis specifically recognizing the alternative first exons of the two TAF-I isoforms revealed that the cell lines also expressed TAF-Ialpha-NUP214 mRNA. Results of fluorescence in situ hybridization (FISH) and array-based copy number analysis were both consistent with del(9)(q34.11q34.13) as described. Quantitative genomic PCR also confirmed loss of genomic material between SET and NUP214 in both cell lines. Genomic sequencing localized the breakpoints of the SET gene to regions downstream of the stop codon and to NUP214 intron 17/18 in both LOUCY and MEGAL cells. Both cell lines expressed the 140 kDa SET-NUP214 fusion protein.Cell lines LOUCY and MEGAL express the recently described SET-NUP214 fusion gene. Of special note is that the formation of the SET exon 7/NUP214 exon 18 gene transcript requires alternative splicing as the SET breakpoint is located downstream of the stop codon in exon 8. The cell lines are promising model systems for SET-NUP214 studies and should facilitate investigating cellular functions of the the SET-NUP214 protein.
Beta-blockade in subarachnoid haemorrhage.
Authors: H L Elliott, B C Campbell, I Morgan
Journal: BMJ (1978)

associated-as is now becoming apparent.Indeed, the situation with regard to both B27 and B5 associations may vary in different parts of the world.In our patients with Behqet's triad, two out of four are B5 positive and one out of four is B27 positive.Of those with "definite" Behqet's disease (by the criteria of Mason and Barnes5), two out of 11 are B5 positive and only one out of 11 is B27 positive.The connection with the B5 antigen seems less strong than in Turkey but further work is necessary to clarify the position.The criteria of Mason and Barnes are valuable in indicating some measure of diagnostic certainty.Patients with the triad of symptoms undoubtedly have Behqet's syn- drome.But some patients satisfy their criteria at the "definite" level without the concurrence of mouth and genital ulceration which I would now regard as obligatory.Nor would I attach much importance to the presence or absence of a family history.Thus the stated prevalence rate of 0 064 per 10 000 can be only an estimate of the disorder's prevalence: it may be a slight overestimate.In any event it contrasts markedly with the Japanese finding of 1 in 10 000.
The capillarity of left ventricular tissue of rats subjected to coronary artery occlusion
Authors: Z XIE, M GAO, S BATRA, T KOYAMA
Journal: Cardiovascular Research (1997)

Objective: The effects of chronic coronary occlusion on the capillarity of left ventricular tissue in rat heart. Methods: The heart was exposed through a left-sided thoracotomy in ethylether-anesthetized and ventilated rats. The left coronary artery was occluded with a thin suture and the thorax was closed. Thirty days after the surgery the heart was removed and cross-sections were made for morphometric analyses. Results: The cross-sectional area of cardiomyocytes increased markedly in the subepi- and subendocardia with a concomitant increase in the capillary to myocyte ratio. The total capillary density increased in the non-ischemic zone. The balance between the increase in capillary density and myocyte hypertrophy was assessed from the capillary domain area (CDA). CDAs were significantly smaller for the venular capillary portion in the subendocardial non-ischemic zone. However, CDAs in the transition zone around the necrosis were significantly increased in the venular capillary portion in the subendocardium and in all capillary portions in the subepicardium compared with those in the non-ischemic zone. Immunohistological staining for basic fibroblast growth factor (bFGF) revealed punctate bFGF distribution in both the non-ischemic and transition zones of ventricular tissues 30 days after occlusion, suggesting a persistent stimulation for capillary angiogenesis. Conclusion: The remodelling of the capillary bed is not uniform throughout the cardiac tissue in coronary-occluded rat hearts. CDAs decreased in the non-ischemic zone but increased in the transition zone. The rate of capillary angiogenesis failed to parallel the development of hypertrophy in the transition zone over 30 days, as could be seen from the significant reduction in the percentage of venular capillary portions.
Factors Influencing Bone Lead Concentration in a Suburban Community Assessed by Noninvasive K X-ray Fluorescence
Authors: Michael J. Kosnett
Journal: JAMA (1994)

To determine the influence of demographic, exposure and medical factors on the bone lead concentration of subjects with background (nonindustrial) environmental lead exposure.Survey.Suburban residential community.A total of 101 subjects (49 males, 52 females; aged 11 to 78 years) were recruited from 49 of 123 households geographically located in a suburban residential neighborhood unexposed to any major source of industrial lead emissions.Cortical bone lead concentrations in the midshaft of the tibia were noninvasively measured by in vivo K x-ray fluorescence. Blood lead concentrations were measured by anodic stripping voltammetry. An administered questionnaire assessed potential sources of lead exposure and medical conditions affecting bone metabolism.After the exclusion of one outlier, log-transformed bone lead concentration was highly correlated with age (r = .71; P < or = .0001). Bone lead concentration showed no significant change up to age 20 years, increased with the same slope in men and women between ages 20 and 55 years, and then increased at a faster rate in men older than 55 years. In addition to the variables age and sex, the best fitting multiple regression model for bone lead concentration (R2 = .66; P < or = .0001) revealed a positive correlation with total pack-years of cigarette smoking and a negative correlation with a history of having nursed an infant for longer than 2 weeks. Blood lead concentrations of the subjects were low (geometric mean, 0.24 mumol/L [4.9 micrograms/dL]) and after log transformation were weakly correlated with log-transformed bone lead concentration (r = .23; P = .02).The age- and sex-related increases in bone lead concentration found by K x-ray fluorescence concur with published postmortem studies of bone lead concentration and are consistent with the kinetics of bone turnover and secular trends in lead exposure. These data help to establish a reference range for assessing the lead burden of other populations with environmental or occupational lead exposure.
Health and social services "locked in a vicious circle"
Authors: A. Ferriman
Journal: BMJ (2000)

Two thirds of hospital beds in England and Wales are occupied by people aged over 65, but many of these people could move out of hospital sooner, or need not be there at all, if they had access to more effective rehabilitation services, the Audit Commission has found.

The commission's latest report states that health and social services are locked in a vicious circle. Rising hospital admissions and falling lengths of stay are reducing time for recovery and rehabilitation and are leading to increasing and unsustainable demands on …
1 Assessment of Health Literacy and Asthma Outcomes in the Primary Care Setting
Authors: Mark Stevens, M. Bridget Zimmerman, Mary Beth Fasano
Journal: Journal of Allergy and Clinical Immunology (2013)

A large segment of the American population is functionally illiterate; a finding associated with worse overall health outcomes. Physicians however are not adept at recognizing illiteracy and the connection between health literacy and asthma outcomes is not well established. We hypothesized a short questionnaire could be used to identify patients with low health literacy and that functional illiteracy is a risk factor for worse asthma outcomes. A cross-sectional cohort pilot study at an academic medical center assessed literacy in adult asthmatics using the Newest Vital Sign (NVS) questionnaire. Asthma outcomes were measured by the Asthma Control Test (ACT) and mini-Asthma Quality of Life Questionnaire (m-AQLQ). Spearman correlation (ρ) was used to examine the relationship between NVS scores and asthma outcomes. A P value of <0.2 was considered statistically significant. 49 subjects completed the study. A significant correlation was found between NVS score and both asthma outcomes (NVS and ACT: ρ=0.22 [CI -0.06 – 0.48], P=0.12; NVS and m-AQLQ: ρ=0.33 [CI 0.06 - 0.56], P=0.02). This correlation increased in subjects reporting difficulty affording medications (ρ=0.59 [CI 0.09 - 0.85], P=0.02 and ρ=0.60 [CI 0.10 - 0.86], P=0.02) for the ACT and m-AQLQ respectively. Subjects with recent asthma exacerbations had significantly lower NVS scores (P=0.02). Health illiteracy as measured by the NVS was correlated with worse asthma outcomes and associated with recent asthma exacerbation. This correlation was more pronounced among those with difficulty affording medications. The NVS may be a useful tool for clinicians to assess health literacy in the primary care setting.
Comprehensive DNA Copy Number Profiling of Meningioma Using a Chromosome 1 Tiling Path Microarray Identifies Novel Candidate Tumor Suppressor Loci
Authors: Patrick G. Buckley, Caroline Jarbo, Uwe Menzel, Tiit Mathiesen, Carol Scott, Simon G. Gregory, Cordelia F. Langford, Jan P. Dumanski
Journal: Cancer Research (2005)

Abstract Meningiomas are common neoplasms of the meninges lining of the central nervous system. Deletions of 1p have been established as important for the initiation and/or progression of meningioma. The rationale of this array-CGH study was to characterize copy number imbalances of chromosome 1 in meningioma, using a full-coverage genomic microarray containing 2,118 distinct measurement points. In total, 82 meningiomas were analyzed, making this the most detailed analysis of chromosome 1 in a comprehensive series of tumors. We detected a broad range of aberrations, such as deletions and/or gains of various sizes. Deletions were the predominant finding and ranged from monosomy to a 3.5-Mb terminal 1p homozygous deletion. Although multiple aberrations were observed across chromosome 1, every meningioma in which imbalances were detected harbored 1p deletions. Tumor heterogeneity was also observed in three recurrent meningiomas, which most likely reflects a progressive loss of chromosomal segments at different stages of tumor development. The distribution of aberrations supports the existence of at least four candidate loci on chromosome 1, which are important for meningioma tumorigenesis. In one of these regions, our results already allow the analysis of a number of candidate genes. In a large series of cases, we observed an association between the presence of segmental duplications and deletion breakpoints, which suggests their role in the generation of these tumor-specific aberrations. As 1p is the site of the genome most frequently affected by tumor-specific aberrations, our results indicate loci of general importance for cancer development and progression.
Intraoperative Cholangiography During Cholecystectomy—Reply
Authors: Taylor S. Riall, Kristin M. Sheffield, Yong-Fang Kuo
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends in US Emergency Department Visits—Reply
Authors: Ning Tang, Renee Y. Hsia, Ralph Gonzales
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal