tbuckley/cabot-search huggingface dataset:
Anxiety Sensitivity Profile: Dimensional Structure and Relationship with Temperament and Character
Authors: Willem van der Does, Inge Duijsens, Elisabeth Eurelings-Bontekoe, Margot Verschuur, Philip Spinhoven
Journal: Psychotherapy and Psychosomatics (2003)

Anxiety sensitivity (AS), the belief that bodily sensations have harmful consequences, is a reliable predictor of panic attacks in both clinical and nonclinical populations. Recently, a new measure of AS has been proposed. The AS profile (ASP) was designed to be a more comprehensive measure of AS, and to be more suitable for the measurement of different AS dimensions. Preliminary evidence (college student sample) suggests that the ASP has 4 dimensions. In the present study, the dimensional structure of the ASP was further investigated, as well as its relationship with temperament and character traits.Exploratory and confirmatory factor analysis of ASP scores in two large samples of psychiatric outpatients and nonclinical controls (combined n = 742). Correlations and partial correlations of ASP with temperament and character.Exploratory factor analysis yielded a single AS factor. However, confirmatory factor analysis showed that the 6-dimensional structure, as Taylor and Cox had originally intended it, might be a defendable solution. However, the number of items is much too high, with many subscales consisting of semantic clusters. ASP scores were found to be weakly related to the temperament dimension harm avoidance, corroborating earlier findings that were not statistically significant because of small sample sizes.The ASP may be shortened from 60 to 24 items without loss of reliability or content. Future studies using challenge paradigms and studies with general hospital patients may further investigate the usefulness of a shortened version of the ASP.
Cigarette Smoking and Levels of Adrenal Androgens in Postmenopausal Women
Authors: Kay-Tee Khaw, Sallie Tazuke, Elizabeth Barrett-Connor
Journal: New England Journal of Medicine (1988)

An antiestrogenic effect of cigarette smoking has been suggested, principally on the basis of data on premenopausal women. We examined the relation between cigarette smoking and endogenous sex-hormone levels in a population of 233 white, postmenopausal women 60 to 79 years of age. Current cigarette smokers had significantly higher mean plasma levels of the adrenal androgens dehydroepiandrosterone sulfate and androstenedione than nonsmokers. Mean levels for smokers and nonsmokers were 3.1 μmol per liter (116 μg per deciliter) and 2.3 μmol per liter (86 μg per deciliter), respectively (P<0.001), for dehydroepiandrosterone sulfate, and 27.8 nmol per liter (797 pg per milliliter) and 22.5 nmol per liter (643 pg per milliliter), respectively (P = 0.002), for androstenedione. A dose–response relation was apparent for these hormones; mean plasma levels increased concomitantly with cigarette consumption. The differences in hormone levels remained after adjustment for age and body-mass index. Mean levels of estrone, estradiol, testosterone, and sex-hormone–binding globulin did not differ between smokers and nonsmokers. These results suggest that the possible decreased risk of breast and endometrial cancer associated with cigarette smoking may not be mediated through lower levels of endogenous estrogen, at least in postmenopausal women, and they raise questions about the role of androgens in disease mechanisms in older populations. (N Engl J Med 1988; 318:1705–9.)
Nebulized Hypertonic Saline for Bronchiolitis—Reply
Authors: Chris Baker, Sheree M. Schrager, Susan Wu
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Abstract 1513: Short And Long-term Mortalitty In Chest-Pain Patients Ruling-in For Myocardial InfarctionI: STEMI Versus Non-STEMI In The Era Of A Troponin-based Definition For MI
Authors: Michael C Kontos, Thomas T Noel, Charlotte S Roberts, F Philip Anderson, James L Tatum, Joseph P Ornato, Robert L Jesse
Journal: Circulation (2007)

Background: Several randomized clinical trials have demonstrated that patients (pts) with ST Elevation myocardial infarction (STEMI) have a higher short-term mortality than those with non-STEMI, but that long-term mortality is similar. More recent studies suggest that pts who are troponin positive (TnI+), but not meeting the older CKMB criteria for MI may also be at increased risk. However, there is little data examining outcomes differentiating these 3 MI populations using the current ACC/ESC definition for MI selected from a heterogeneous cohort of pts admitted from the emergency department. Methods: Consecutive pts admitted for exclusion of myocardial ischemia underwent serial sampling of CK, CKMB, and TnI. MI was defined using ACC/ESC criteria. Pts were separated into 3 groups: STEMI (n=363; 22%), non-STEMI pts who met the prior CKMB criteria for MI (n=743; 46%), and non-STEMI pts who had MI based on TnI (+) alone (n=512; 32%) without meeting CKMB MI criteria. Demographic and clinical variables were compared among the three cohorts of patients, and 30 day and 1 year mortality were assessed. Results : Over a 6 year period, 1,618 pts were diagnosed with MI. Co-morbidities and outcomes are shown below in the table . Variables associated with worse outcomes were significantly more common in both groups of non-STEMI pts, particularly in the TnI (+) only pts. Thirty day mortality was similar and not significantly different among the 3 cohorts. However, at 1 year, mortality was a significant 68% higher in the 2 non-STEMI groups, despite having significantly lower peak CK (median 123 U/L for TnI (+) pts and 414 U/L for CKMB MI pts vs 1400 U/L for STEMI pts) and CKMB values (median 4 ng/ml for TnI (+) pts and 29 ng/ml for CKMB MI pts vs 140 ng/ml for STEMI pts) compared to STEMI pts. Conclusions : All MI pts had similar 30 day mortality; however, at 1 yr pts with non-STEMI had a substantially increased mortality compared to STEMI pts.
Delay, shame, and blame
Authors: Des Spence
Journal: BMJ (2008)

These days GPs don’t like reading the newspapers—they tell us that we are overpaid and lazy. Our punishment is a contract in constant flux; a change to “advanced appointment access,” whereby patients spend all day on the phone, never to see their preferred doctor and certainly never at a time that suits them; and, now, “additional hours” that nobody seems to want or need. All this doesn’t bother me much, for it is the turn of fashion. But when an eminent super-specialist …
<i>In Vivo</i> Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Mirentxu Santos, Mónica Martínez-Fernández, Marta Dueñas, Ramón García-Escudero, Begoña Alfaya, Felipe Villacampa, Cristina Saiz-Ladera, Clotilde Costa, Marta Oteo, José Duarte, Victor Martínez, Ma José Gómez-Rodriguez, Ma Luisa Martín, Manoli Fernández, Patrick Viatour, Miguel A. Morcillo, Julien Sage, Daniel Castellano, Jose L. Rodriguez-Peralto, Federico de la Rosa, Jesús M Paramio
Journal: Cancer Research (2014)

Bladder cancer is a highly prevalent human disease in which retinoblastoma (Rb) pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here, we show that the in vivo inactivation of all Rb family genes in the mouse urothelium is sufficient to initiate bladder cancer development. The characterization of the mouse tumors revealed multiple molecular features of human bladder cancer, including the activation of E2F transcription factor and subsequent Ezh2 expression and the activation of several signaling pathways previously identified as highly relevant in urothelial tumors. These mice represent a genetically defined model for human high-grade superficial bladder cancer. Whole transcriptional characterizations of mouse and human bladder tumors revealed a significant overlap and confirmed the predominant role for Ezh2 in the downregulation of gene expression programs. Importantly, the increased tumor recurrence and progression in human patients with superficial bladder cancer is associated with increased E2F and Ezh2 expression and Ezh2-mediated gene expression repression. Collectively, our studies provide a genetically defined model for human high-grade superficial bladder cancer and demonstrate the existence of an Rb-E2F-Ezh2 axis in bladder whose disruption can promote tumor development.
Proinsulin, Intact Insulin, and Fibrinolytic Variables and Fibrinogen in Healthy Subjects: A population study
Authors: Mats Eliasson, Michael E Røder, Bo Dinesen, Per-Eric Evrin, Bernt Lindahl
Journal: Diabetes Care (1997)

OBJECTIVE As high serum insulin predicts impaired fibrinolysis and proinsulin reacts in most conventional insulin assays, we hypothesized that proinsulin could link low fibrinolytic activity and hyperinsulinemic conditions. RESEARCH DESIGN AND METHODS We explored the relationship between fibrinolysis and plasma fibrinogen on the one hand and specific insulin and proinsulin on the other, in a healthy population sample of 165 men and women, 25–74 years of age, from the Northern Sweden MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) Study. Specific insulin and proinsulin were measured by enzyme-linked immunosorbent assay. Partial correlation coefficients, adjusted for age and sex, were calculated. RESULTS Plasma fibrinogen levels were related to insulin (r = 0.25, P &amp;lt; 0.01) and proinsulin (r = 0.29, P &amp;lt; 0.001), as was plasminogen activator inhibitor (PAI)-1 activity (r = 0.36 and r = 0.29, respectively; P &amp;lt; 0.001). Tissue Plasminogen activator (tPA) activity correlated inversely to insulin (r = −0.35, P &amp;lt; 0.001) and proinsulin (r = −0.36, P &amp;lt; 0.001). In a multivariate analysis taking also smoking and anthropometric and metabolic measurements into account, fasting proinsulin was a significant predictor of high plasma fibrinogen level. Insulin and proinsulin levels were not related to tPA activity. High levels of postload insulin, triglycerides, and diastolic blood pressure, but not proinsulin, predicted high PAI-l activity. CONCLUSIONS In a healthy population, the relationship previously described between high insulin levels and impaired fibrinolysis is not attributable to confounding from proinsulin. Elevated proinsulin levels are associated with high fibrinogen levels.
Hyperglycaemic conditions hamper keratinocyte locomotion via sequential inhibition of distinct pathways: new insights on poor wound closure in patients with diabetes
Authors: C-C.E. Lan, C-S. Wu, H-Y. Kuo, S-M. Huang, G-S. Chen
Journal: British Journal of Dermatology (2009)

Background Diabetes mellitus (DM) is characterized by impaired insulin signalling, elevated plasma glucose, and predisposition towards complications involving several organs. A major complication of DM is impairment of wound healing. In the re‐epithelialization process during wound healing, migration of keratinocytes is a crucial step. Our previous report demonstrated that keratinocytes cultured in hyperglycaemic media showed decreased cell mobility. Objectives The current study aimed to explore the effects of high glucose on keratinocyte migration after different treatment durations. Methods Keratinocytes were cultivated for indicated time periods under various concentrations of glucose. Relevant assays including Transwell migration and in vitro wound scratch assays, flow cytometric analysis, matrix metalloproteinase‐1 (MMP‐1) activity assay, determination of mRNA expression and Western blotting were performed. Results We demonstrated that (i) keratinocyte motility progressively and significantly decreased; (ii) the keratinocyte activation marker K16 was significantly suppressed; (iii) expression of α2β1 integrin and MMP‐1, both crucial for keratinocyte locomotion on collagen type I, was significantly downregulated; and (iv) expression of the phosphorylated signal transducer and activator of transcription‐1 significantly decreased after hyperglycaemic treatment. More specifically, different pathways become involved after prolonged duration of high glucose cultivation to reduce keratinocyte locomotion further. Conclusions We have demonstrated that high glucose treatment results in progressive suppression of keratinocyte locomotion and elucidated the molecular mechanisms involved. These results provide a reasonable explanation for the poor wound healing seen in patients with DM.
A MEMORABLE PATIENT
Authors: R. A Millar
Journal: BMJ (1996)

Seeking escape, with the usual relief, my toothache quelled, I was halted abruptly by his request—would I please anaesthetise the next patient? I nodded reflexly as a silent, inward voice said: “I don't do this. I'm sorry … a matter of principle … in the dental chair.” For I had not quite adapted to “consultant anaesthetist, UK.”

The apparatus was a Walton number something, with simple controls for gas pressure and concentration—an immediate …
Reduction in Clostridium difficile Infection Rates after Mandatory Hospital Public Reporting: Findings from a Longitudinal Cohort Study in Canada
Authors: Nick Daneman, Therese A. Stukel, Xiaomu Ma, Marian Vermeulen, Astrid Guttmann
Journal: PLoS Medicine (2012)

A population-based study conducted by Nick Daneman and colleagues in Ontario, Canada reports on the association between population reporting of hospital infection rates and a reduction in population burden of Clostridium difficile colitis.
TCT-221 Diagnostic Performance of Intracoronary Gradient-Based Methods by Coronary Computed Tomography Angiography for the Evaluation of Physiologically Significant Coronary Artery Stenoses: A Validation Study with FFR
Authors: Jin-Ho Choi, Bon-Kwon Koo, Young-Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Yeonhyon Choe, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2012)
Life expectancy in Great Britain rises—but later years are still spent in poor health
Authors: Karen Hébert
Journal: BMJ (2004)

People are living longer but the extra years are not lived in good health, show new data published by the Office for National Statistics.

Life expectancy in Great Britain increased between 1981 and 2001. Females born in 2001 can now expect to live an average of 80.4 years (versus 76.8 years in 1981) and males an average of 75.7 years (versus 70.9 years). Although women have also in the past had a longer …
Milburn visits Spain for doctors and ideas
Authors: X. Bosch
Journal: BMJ (2001)

The UK health secretary, Alan Milburn, visited Spain last week as part of an NHS campaign to recruit doctors from abroad and to garner new ideas that might be useful to the NHS.

Mr Milburn visited a new type of Spanish hospital, known as a public health foundation, which, though owned by the state health service, is run through a private management scheme. It also has a great deal of autonomy from the state health service and can raise money from the private sector.

In November last year, Spanish health minister Celia Villalobos and Mr Milburn signed an agreement that was initially aimed at recruiting Spanish nurses to meet the NHS target for nurses in 2004. Since the agreement, 400 nurses have been recruited.

The agreement also opened the door to recruit Spanish doctors. While 100 foreign doctors have already applied to …
A Comparison of Coronary Flow Determined by the Nitrous Oxide Method and by a Direct Method Using the Rotameter
Authors: DONALD E. GREGG, FRANK H. LONGINO, PAUL A. GREEN, LAWRENCE J. CZERWONKA
Journal: Circulation (1951)

Coronary flow per minute per 100 Gm. of heart with venous drainage into the coronary sinus as measured by the nitrous oxide procedure was compared in the dog with left coronary artery inflow per 100 Gm. of heart perfused by this artery as measured by the rotameter. The error arising from epicardial leak of nitrous oxide was prevented or quantitated by appropriate coverage of the heart. Extremes of the comparisons were +21 and -22 per cent, with an average variation of ±12.4 per cent. The nitrous oxide method is regarded as giving semiquantitative coronary flow values per 100 Gm. of left heart in the dog.
Diltiazem and Thrombocytopenia
Authors: Meir Lahav, Ravit Arav
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 February 1989Diltiazem and ThrombocytopeniaMeir Lahav, MD, Ravit Arav, MDMeir Lahav, MDSearch for more papers by this author, Ravit Arav, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-4-327_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Calcium-channel blockers are widely used as antianginal and antihypertensive treatments. Diltiazem is associated with a relatively low incidence of side effects. We report a case of hypersensitivity reaction to diltiazem manifested by thrombocytopenia, spiking fever, hepatotoxicity, and rash. To our knowledge, this is the first report of thrombocytopenia due to diltiazem.A 61-year-old man was hospitalized with a fever of 5 days' duration. He had been treated for several years with nifedipine, isosorbide dinitrate, and dipyridamole. Diltiazem therapy, 60 mg three times a day, was started 7 days before his hospitalization.On admission, the patient's temperature was...References1. SchroederBeier-ScottGinsburgBristowMcAuley JLRMB. Efficacy of diltiazem for medically refractory stable angina: longterm follow up. Clin Cardiol. 1985;8:480-5. CrossrefMedlineGoogle Scholar2. SarachekLondonMatulewicz NRT. Diltiazem and granulomatous hepatitis. Gastroenterology. 1985;88:1260-2. CrossrefMedlineGoogle Scholar3. QuigleyWhiteMcGraw MKB. Interpretation and application of worldwide safety data on diltiazem. Acta Pharmacol Toxicol. 1985;57(suppl II):61-73. MedlineGoogle Scholar4. SaundersShedden FP. Diltiazem: possible hematologic complications. Surg Neurol. 1986;25:82-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLevofloxacin-Induced Acute Immune-Mediated Thrombocytopenia of Rapid-OnsetMaculopapular rash induced by diltiazem: allergological investigations in four patients and cross reactions between calcium channel blockersAn Unusual Case of Thrombocytopenia and Leukopenia Associated with Diltiazem and AcyclovirAb initio and molecular dynamics study of dibenzotricyclic calcium antagonists: A rigid model approachHematologic complications of diltiazem overdoseβ-Adrenoceptor antagonists and antianginal drugs 15 February 1989Volume 110, Issue 4Page: 327-327KeywordsFeversHospitalizationsHypersensitivityRashesTemperature Issue Published: 15 February 1989 PDF DownloadLoading ...
Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases
Authors: Randi J. Bertelsen, Anne Lise Brantsæter, Maria C. Magnus, Margaretha Haugen, Ronny Myhre, Bo Jacobsson, Matthew P. Longnecker, Helle M. Meltzer, Stephanie J. London
Journal: Journal of Allergy and Clinical Immunology (2013)
ADHD is a risk factor for premature death, Danish study shows
Authors: J. Young
Journal: BMJ (2015)

Attention deficit hyperactivity disorder (ADHD) is associated with significantly higher mortality rates, although the absolute risk is low, a large Danish study has found.

The prospective cohort study, published in the Lancet ,1 found that accidents were the most common cause of death in people with ADHD and that the relative risk of dying was much higher among women than men, as well as among those who had the condition diagnosed in adulthood rather than in childhood.

The study included all children born in Denmark from 1981 to 2011 with almost complete follow-up data for as long …
Role of K+ ATP channels and adenosine in the regulation of coronary blood flow during exercise with normal and restricted coronary blood flow.
Authors: D J Duncker, N S van Zon, Y Ishibashi, R J Bache
Journal: Journal of Clinical Investigation (1996)

Regulation of coronary vasomotor tone during exercise is incompletely understood. We investigated the contributions of K+ ATP channels and adenosine to the coronary vasodilation that occurs during exercise in the normal heart and in the presence of a coronary artery stenosis. Dogs that were chronically instrumented with a Doppler flow probe, hydraulic occluder, and indwelling catheter on the left anterior descending coronary artery were exercised on a treadmill to produce heart rates of approximately 200 beats/min. By graded inflation of the occluder to produce a wide range of coronary stenosis severities, we determined the coronary pressure-flow relation. K+ atp channel blockade with intracoronary glibenclamide (10-50 microgram/kg per min) decreased coronary blood flow during exercise at coronary pressures within and below the autoregulatory range, indicating that coronary K+ ATP channel activation is critical for producing coronary vasodilation with either normal arterial inflow or when flow is restricted by a coronary artery stenosis. Adenosine receptor blockade with intravenous 8-phenyltheophylline (5 mg/kg) had no effect on coronary flow at pressures within the autoregulatory range but decreased flow at pressures < 55 mmHg. In contrast, in the presence of K+ ATP channel blockade, the addition of adenosine receptor blockade further decreased coronary flow even at coronary pressures in the autoregulatory range, indicating increased importance of the vasodilator influence of endogenous adenosine during exercise when K+ atp channels are blocked. Intracoronary adenosine (50 microgram/kg per min) increased coronary flow at perfusion pressures both within and below the autoregulatory range. In contrast, selective K+ ATP channel activation with intracoronary pinacidil (0.2-5.0 microgram/kg per min) increased flow at normal but not at lower coronary pressures (< 55 mmHg). This finding demonstrates that not all K+ ATP channels are activated during exercise at pressures in the autoregulatory range, but that most K+ ATP channels are recruited as pressures approach the lower end of the autoregulatory plateau. Thus, K+ ATP channels and endogenous adenosine play a synergistic role in maintaining vasodilation during exercise in normal hearts and distal to a coronary artery stenosis that results in myocardial hypoperfusion during exercise.