tbuckley/cabot-search huggingface dataset:
Nigel Henry Harris
Authors: Andrew Harris
Journal: BMJ (2007)

Long before the contemporary drive for patient choice, Nigel Harris was a doctor who championed patient's interests. He was an orthopaedic surgeon to St Charles and St Mary's Hospital in London for 26 years. Soon after arriving there at St Charles' in 1964, where he became head of the orthopaedic department, he set about addressing waiting lists. He informed general practitioners all over the country when his department had empty beds, so that those who had been waiting for hip or knee replacement in other places could be admitted and his department work to full capacity. He insisted on giving the date of their operation to all his patients at the time they attended outpatients, much to the displeasure of administrators of the time. Government policy today is trying to achieve similar benefits for NHS patients everywhere: Nigel Harris did it 35 years ago without managerial dictat. In many ways, he was a man before his time. He gave publicity to the patient safety implications of allowing doctors who had trained abroad to practise when their English was not adequate. He was accused of being racially motivated by an MP, and, without support from the medical profession or any financial capital, he successfully privately sued the MP for slander. Nowadays it is routinely accepted that to practise medicine all doctors must demonstrate an adequate standard of English.

Nigel Henry Harris was born in 1924, and as a child showed considerable sporting prowess. At school he became victor …
Meta-Analysis: Risk for Hypertension in Living Kidney Donors
Authors: Neil Boudville, G. V. Ramesh Prasad, Greg Knoll, Norman Muirhead, Heather Thiessen-Philbrook, Robert C. Yang, M. Patricia Rosas-Arellano, Abdulrahman Housawi, Amit X. Garg
Journal: Annals of Internal Medicine (2006)

Background: The risk for hypertension after kidney donation remains uncertain. Purpose: To see whether normotensive adults who donate a kidney develop higher blood pressure and risk for hypertension compared with nondonor adults acting as control participants. Data Sources: MEDLINE, EMBASE, and Science Citation Index were searched from 1966 until November 2005 for articles published in any language. Reference lists of pertinent articles were also reviewed. Study Selection: The authors selected studies involving 10 or more healthy normotensive adults who donated a kidney and in whom blood pressure was assessed at least 1 year later. Data Extraction: Two reviewers independently abstracted data on study and donor characteristics, blood pressure measurements, outcomes, and prognostic features. Comparison data were abstracted from donor studies with control participants. Thirty primary authors provided additional data. Data Synthesis: Forty-eight studies from 28 countries followed a total of 5145 donors. Before surgery, the average age of donors was 41 years, the average systolic blood pressure was 121 mm Hg, and the average diastolic blood pressure was 77 mm Hg for all studies. In controlled studies in which the average follow-up was at least 5 years after donation (range, 6 to 13 years), blood pressure was 5 mm Hg higher in donors than in control participants (the weighted mean for systolic blood pressure using 4 studies involving 157 donors and 128 control participants was 6 mm Hg [95% CI, 2 to 11 mm Hg], and the weighted mean for diastolic blood pressure using 5 studies involving 196 donors and 161 control participants was 4 mm Hg [CI, 1 to 7 mm Hg]). There was statistical heterogeneity among the 6 controlled studies that assessed hypertension; an increase in risk was noted in 1 study (relative risk, 1.9 [CI, 1.1 to 3.5]). Limitations: Most studies were retrospective and did not include control groups that were assembled and followed along with donors. Approximately one third of the donors had incomplete follow-up information. Conclusions: On the basis of the limited studies conducted to date, kidney donors may have a 5–mm Hg increase in blood pressure within 5 to 10 years after donation over that anticipated with normal aging. Future controlled, prospective studies with long periods of follow-up will better delineate safety and identify donors at lowest risk for long-term morbidity. *For a list of DONOR Network Investigators, see the Appendix.
Hyperphosphorylation of Glucosyl C6 Carbons and Altered Structure of Glycogen in the Neurodegenerative Epilepsy Lafora Disease
Authors: Felix Nitschke, Peixiang Wang, Peter Schmieder, Jean-Marie Girard, Donald E. Awrey, Tony Wang, Johan Israelian, XiaoChu Zhao, Julie Turnbull, Matthias Heydenreich, Erich Kleinpeter, Martin Steup, Berge A. Minassian
Journal: Cell Metabolism (2013)
THE EPIDEMIOLOGY OF ANIMAL RINGWORM IN MAN
Authors: MARY P. ENGLISH
Journal: British Journal of Dermatology (1972)

Journal Article THE EPIDEMIOLOGY OF ANIMAL RINGWORM IN MAN Get access MARY P. ENGLISH MARY P. ENGLISH Pathology Laboratory, General Hospital, Guinea Street, Bristol 1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue s8, 1 June 1972, Pages 78–87, https://doi.org/10.1111/j.1365-2133.1972.tb15419.x Published: 01 June 1972
Evaluation of a Laboratory System Intended for Use in Physicians' Offices
Authors: Richard Belsey
Journal: JAMA (1987)

The Kodak DT-60 tabletop chemistry analyzer was evaluated with standardized protocols to determine the system's precision and accuracy when operated by four volunteers (a secretary, a licensed practical nurse, and two family medicine residents) in a simulated office laboratory. The variability of the results was found to be significantly greater than the variability of results produced by medical technologists who analyzed the same samples during the same study period with another DT-60 placed in the hospital laboratory. The source(s) of increased variance needs to be identified so the system can be modified or new control procedures can be developed to ensure the reliability of results used in patient care. Prospective purchasers, manufacturers, and patients need this kind of objective information about the reliability of results produced by systems intended for use in physicians' office laboratories. (<i>JAMA</i>1987;258:357-361)
Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen
Authors: Christoph Steininger, George F. Widhopf, Emanuela M. Ghia, Christopher S. Morello, Katrina Vanura, Rebecca Sanders, Deborah Spector, Don Guiney, Ulrich Jäger, Thomas J. Kipps
Journal: Blood (2012)
Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental
Authors: Peter Andrews, Elie Azoulay, Massimo Antonelli, Laurent Brochard, Christian Brun-Buisson, Geoffrey Dobb, Jean-Yves Fagon, Herwig Gerlach, Johan Groeneveld, Jordi Mancebo, Philipp Metnitz, Stefano Nava, Jerome Pugin, Michael Pinsky, Peter Radermacher, Christian Richard, Robert Tasker
Journal: Intensive Care Medicine (2006)
The dipsomania of great distance: water intoxication in an Ironman triathlete
Authors: T D Noakes, K Sharwood, M Collins, D R Perkins
Journal: British Journal of Sports Medicine (2004)

Of 371 athletes (62% of all finishers) whose weights were measured before and after the 226 km South African Ironman Triathlon, the athlete who gained the most weight (3.6 kg) during the race was the only competitor to develop symptomatic hyponatraemia. During recovery, he excreted an excess of 4.6 litres of urine. This case report again confirms that symptomatic hyponatraemia is caused by considerable fluid overload independent of appreciable NaCl losses. Hence prevention of the condition requires that athletes be warned not to drink excessively large volumes of fluid (dipsomania) during very prolonged exercise. This case report also shows that there is a delayed diuresis in this condition and that it is not caused by renal failure.
The Editor, 'The British Journal of Dermatology'. The identity of lichen planus and lichen nitidus.
Authors: L. Stankler
Journal: British Journal of Dermatology (1967)

Journal Article The Editor, ‘The British Journal of Dermatology’. The identity of lichen planus and lichen nitidus. Get access L. Stankler L. Stankler Royal Infirmary, Glasgow, C4 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 2, 1 February 1967, Pages 125–126, https://doi.org/10.1111/j.1365-2133.1967.tb11472.x Published: 01 February 1967
Home treatment for acute psychiatric disorder.
Authors: P Dedman
Journal: BMJ (1993)

The discussion around the use of the term ‘medical futility’ began in the late 1980s. The Polish Working Group on End-of-Life Ethics (PWG) joined this discussion in 2008. They offered their own approach to the issues regarding medical futility based on the category of persistent therapy. According to the PWG, ‘persistent therapy is the use of medical procedures to maintain the life function of the terminally ill in a way that prolongs their dying, introducing excessive suffering or violating their dignity’. In this paper I attempt to show that the term ‘persistent therapy’ is neither worse nor better than the term ‘medical futility’, but it captures different aspects and nuances. Additionally, the Polish social and religious background plays a significant role in shaping the category of persistent therapy.
Clinical Consideration of an Anemia of Pregnancy and the Puerperium*
Authors: C. T. SMITH
Journal: Annals of Internal Medicine (1931)

Article1 February 1931Clinical Consideration of an Anemia of Pregnancy and the Puerperium*C. T. SMITH, M.D., F.A.C.P., W. B. KINLAW, M.D., F.A.C.P.C. T. SMITH, M.D., F.A.C.P.Search for more papers by this author, W. B. KINLAW, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-8-939 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPuerperal anemia, which is probably a continuation if not a progression of the anemia of pregnancy, was first described by Channing in 1842,1 and for many decades doubted as being a specific anemia, has received more study in the past two decades and has been established as a definite anemia related to pregnancy and the puerperium; and furthermore according to Murdock's2 observations, "if the patient survives the acute attack, the blood picture usually returns to normal."For an anemia to merit such a classification, we contend that all anemias should be excluded which might be explained by hemorrhage, sepsis (including...Bibliography1 CHANNING W: New England Quart. Jour. Med. & Surg., 1842, 1, 157. Google Scholar2 MURDOCK TP: Ann. Int. Med., 1927, 1, 133. LinkGoogle Scholar3 ROWLAND VC: Ann. Int. Med. 1927, 1, 129. LinkGoogle Scholar4 ESCH : Zentralbl, f. Gynäk, 50, 857. Google Scholar5 PEPPER OH: Med. Clin. N. A., 12, 932. Google Scholar6 CABOTOSLER : Med. Clin. N. A., 12, 927. Google Scholar7 SMITH CT: Surg. Gyn. & Obst., 1925, 40, 223. Google Scholar8 ALDER : Zeitschr, f. Geburtsch, u, Gyn., 1924, 87, 505. Google Scholar9 MCSWINEY : Indian Med. Gaz., 1927, 62, 487. MedlineGoogle Scholar10 AUBERTIN : Le Bull. Med. 1925, 39, 261. Google Scholar11 BRADY : These Paris, 1923-24. Google Scholar12 ALLAN W: South. Med. Jour. 1929, 22, 624. CrossrefGoogle Scholar13 BRAULT P: Bull. de la Soc. d'Obs. & Gyn. Paris, March 1928. Google Scholar14 LARRIBERE : Bull. de la Soc. d'Obs. & Gyn. Paris, April 1928. Google Scholar15 PETERSON : J.A.M.A., 1930, 94, 839. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C. T. SMITH, M.D., F.A.C.P.; W. B. KINLAW, M.D., F.A.C.P.Affiliations: Medical Service Park View Hospital Rocky Mount, N. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE PATHOLOGY AND TREATMENT OF ANEMIA. 1 February 1931Volume 4, Issue 8Page: 939-944KeywordsAnemiaBloodHemorrhagePregnancySepsis ePublished: 1 December 2008 Issue Published: 1 February 1931 PDF downloadLoading ...
ARTIFICIAL RESPIRATION IN ASPHYXIA NEONATORUM
Authors: Clarence L. Heald
Journal: JAMA (1918)

Of the classic methods of artificial respiration in asphyxia neonatorum, mouth-to-mouth insufflation has proved more efficient than the methods dependent on manipulation of the child. The manipulative methods of Prochownick (rhythmic compression of the child's chest in inverted suspension), rhythmic flexion and extension of the child's body, and Schultz' swingings are all useful in asphyxia livida, but in the more critical condition of asphyxia pallida, mouth-to-mouth insufflation or insufflation through a tracheal catheter will frequently succeed after these methods have failed. There are, however, serious objections to mouth-to-mouth insufflation: 1. The delicate air vesicle may be ruptured. Bichat has proved the possibility of blowing air into the vessels near the heart if too much force is used. 2. There is danger of infection of the child by the operator. 3. The insufflated air has already been deprived of much of its oxygen, and is laden with carbon dioxid. 4. The
Leukocyte function in granuloma annulare
Authors: KENNETH J. CHERNEY, WILLIAM E. LINDROOS, ROBERT W. GOLTZ, MARK V. DAHL
Journal: British Journal of Dermatology (1979)

Journal Article Leukocyte function in granuloma annulare Get access KENNETH J. CHERNEY, KENNETH J. CHERNEY Department of Dermatology, University of Minnesota Medical Center, Minneapolis, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar WILLIAM E. LINDROOS, WILLIAM E. LINDROOS Department of Dermatology, University of Minnesota Medical Center, Minneapolis, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar ROBERT W. GOLTZ, ROBERT W. GOLTZ Department of Dermatology, University of Minnesota Medical Center, Minneapolis, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar MARK V. DAHL MARK V. DAHL Department of Dermatology, University of Minnesota Medical Center, Minneapolis, U.S.A. Dr M.V.Dahl, Box 98, Mayo, University of Minnesota Hospitals, Minneapolis, MN 55455, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 101, Issue 1, 1 July 1979, Page 23, https://doi.org/10.1111/j.1365-2133.1979.tb15288.x Published: 01 July 1979
SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE
Authors: Robert E. Tigelaar, Richard Asofsky
Journal: The Journal of Experimental Medicine (1973)

Spleen cells from normal adult mice were injected into lethally irradiated adult syngeneic recipients. 24 h later, cell suspensions were prepared from the recipients' spleens or peripheral lymph nodes and tested either alone or combined for their capacity to elicit graft-versus-host (GVH) reactions in neonatal F(1) recipients, using the Simonsen spleen weight assay. Either the lymph node-seeking subpopulation or the spleen-seeking subpopulation alone was markedly deficient in its ability to provide a GVH reaction when compared with the normal population from which it was derived. However, an appropriate mixture of the two had a reactivity characteristic of the parent population. Both subpopulations were sensitive to treatment with anti-theta antibody and complement in vitro. These results provide a convincing demonstration of the functional heterogeneity within the pool of thymus-derived cells present in a single normal lymphoid tissue. They strongly suggest that the normal expression of GVH reactivity of such a tissue involves an interaction among distinct subpopulations of thymus-derived cells.
Atopy predisposing to acute bronchiolitis during an epidemic of respiratory syncytial virus.
Authors: I Laing, F Reidel, P L Yap, H Simpson
Journal: BMJ (1982)

Thirty-one infants admitted to hospital with acute bronchiolitis during an epidemic of respiratory syncytial virus were compared with a control group of 32 infants to establish whether the two groups differed in atopic background. Past history of respiratory illness, eczema, and present reactions to skin testing differed significantly between the two groups. Thus, infants with acute bronchiolitis had a significantly higher atopic predisposition than the controls.
Late prurigo of pregnancy
Authors: W.R. FABER, T.H. VAN JOOST, R. HAUSMAN, G.H. WEENINK
Journal: British Journal of Dermatology (1982)

Seven patients who developed a characteristic pruritic rash in late pregnancy are described. Clinically, the lesions consisted of erythematous urticarial papules and plaques, with vesicles in some cases. The eruption started in the striae on the abdomen and spread over the thighs and in most cases also over the arms and buttocks. Biopsy showed lymphocytic vasculitis with a varying admixture of eosinophils and only minor epidermal changes. Immunofluorescence examination of six cases showed C3 deposition among the dermoepidermal junction in only one case. The lymphocytes, identified by a specific anti-T-cell serum, appeared to be mostly T-cells. The nomenclature of pruritic skin disease in late pregnancy is confusing, but the term 'late prurigo of pregnancy' seems appropriate for this condition.
Beyond the Bench: Healthy Home, Healthy Community
Authors: Tanya Tillett
Journal: Environmental Health Perspectives (2007)

A physician who conducted some of the first studies documenting the effect of lead poisoning on children.An epidemiologist studying the effects of exposure to diethylstilbestrol (DES).A toxicologist pointing out the many different chemical exposures associated with impulsivity.Though each of their disciplines uses a different language, all of these scientists study the links between the environment and childhood disease.They are just a few of the researchers who converged at the "Children's Environmental Health Research: Past, Present, and Future" conference held 22-23 January 2007 at the NIEHS.Sponsored in full by the NIEHS and planned jointly with the EPA, the conference aimed to get scientists talking about what types of research have been most effective.The result was recommendations to help chart the course for NIEHS children's environmental health research over the next five to ten years, including the future of the Centers for Children's Environmental Health and Disease Prevention Research.
A CASE OF ULCERATIVE ENDOCARDITIS OF PUERPERAL ORIGIN
Authors: E. K. MacDonald, G. R. MacNab
Journal: BMJ (1929)

ULCERATIVE ENDOCARDITIS OF PUERPERAI ORIGEW.[DLO He was readmitted in October, 1926, as three sinuses refused to heal; they all communieated, and were probably-due.to a deep infected ligature.They eventually closed after being injected with various substances, such as brilliaant green and crystal violet.CASE IL.This patient, also.a man aged 42, was admitted to the Bristol Royal infirmary on September 17th, 1927.Three weeks previously he had had a right lower molar tooth extracted on account of pain and swelling in the jaw.Between this time and his admission he had had numerous anaesthetics for the extraction of other teeth, the exploration'of his lower jaw, and the opening of sundry abscesses of the face and neck.On adtnission the whole of the right side of the face was greatly swollen; large fluctuating abscesses extended from -below the right angle of the jaw to the riaht temporal region, and he was unable to open his.mouth.The atscesseswere opened freely, actinomvces was 'identified microscopically, and he was put on the' usual treatment.On October -12th he was discharged healed.Some thickening persisted in the tonsillar region, and it was 'three' months -before this had disappeared completely.He has remained well ever since.CASE III.
Sezary's Reticulosis with Exfoliative Dermatitis
Authors: H. T. H. Wilson, J. Fielding
Journal: BMJ (1953)

the more superficial muscle groups.It is known from the experiments of Kellgren, McGowan, and Hughes (1948) that pain in such structures is related to the local tempera- ture.Such an effect must presumably depend on absorption of adrenaline into the general circulation, as penetration to such tissues by direct spread would be unlikely.This would explain the identical relief felt on both sides when adrenaline is applied to only one half of the back (Bywaters, 1951).The delay in recovery which, as our figures indicate, follows the use of adrenaline cream may be due to inter- ference with the pain-defence mechanism.A similar effect on recovery times has been noted when procaine is injected repeatedly into a site of pain in muscle or connective tissue.Whether dry massage produces a similar delay is at present uncertain, but is under investigation. SummaryAdrenaline cream applied locally in a number of rheumatic diseases gives greater relief than a simple cream.Dry massage also gives greater relief than massage with simple cream or no massage at all.No significant difference was noted between the effects of dry massage and massage with adrenaline cream.Repeated application of adrenaline cream appears to delay recovery in rheumatic diseases.We wish to
The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells.
Authors: A Kupfer, S L Swain, S J Singer
Journal: The Journal of Experimental Medicine (1987)

We have produced and investigated cell couples formed between cloned Th cells or T hybridoma cells, and either Ag-presenting B hybridoma or B lymphoma cells. The specific direct interaction between a Th and B-APC is here demonstrated by two rearrangements occurring inside the bound Th cell; the MTOC (and presumably the GA) is oriented to face the cell contact region with the B cell, and a membrane-associated cytoskeletal protein, talin, becomes concentrated under the contacting Th membrane. In the absence of the specific Ag or the correct Ia determinant, nonspecific T-B cell couples form that are morphologically indistinguishable from specific cell couples in the light microscope, but neither the MTOC nor the talin rearrangement occurs inside the bound T cell of such nonspecific couples. Furthermore, Ag processing by the B cell is required to produce the MTOC and talin rearrangements within the T cell in specific T-B couples. In the case of allogeneic Th-B cell couples, similar specific MTOC and talin rearrangements are observed inside the Th. Extracellular Ca2+ is required for the MTOC orientation to occur inside the specifically bound Th cell, but not for the talin rearrangement. It is proposed that the MTOC (and GA) reorientation and the talin rearrangement are involved in the directed secretion of GA-derived lymphokines from the Th cell to the bound B cell.