tbuckley/cabot-search huggingface dataset:
Effects of long-term treatment with low-dose pravastatin on biliary lipid and bile acid composition in patients with nonfamilial hyperlipoproteinemia
Authors: Susumu Tazuma, Itsuo Takizawa, Tetsuro Kunita, Toshiyuki Mizuno, Tetsuhiko Watanabe, Kazushi Teramen, Kazuhiko Horikawa, Hidenori Ochi, Yoshifumi Yamashita, Naoki Aihara, Masatoshi Sasaki, Naomichi Hirano, Hiroyuki Miura, Sumie Hatsushika, Toshihide Ohya, Goro Kajiyama, Katsuhide Itoh
Journal: Metabolism (1995)
Examination of acetabular labral tear: a continued diagnostic challenge
Authors: Michael P Reiman, Richard C Mather, Thomas W Hash, Chad E Cook
Journal: British Journal of Sports Medicine (2013)

Acetabular labrum tears (ALT) are present in 22-55% of individuals with hip or groin pain. Tears can occur as a result of trauma or degeneration and are markedly associated with femoral acetabular morphological variations. An ALT can lead to biomechanical deficiencies and a loss of stability to the coxafemoral joint due to the labrum serving as a stabilising structure of this joint. The diagnosis of ALT is complex and multidimensional. Although tremendous improvements in diagnostic utility for ALT have occurred in the past 25 years, there are few patient history, clinical examination and special test findings that are unique to the condition. Imaging methods such as MRI, CT and ultrasonography have demonstrated reasonable accuracy, but not at a level that allows use as a stand-alone measure. Outcomes measures that focus on functional limitation or that are used to measure recovery should envelop the complexities of the condition and be captured using both self-report and physical performance measures. Only when patient history, objective testing, clinical examination special testing and imaging are combined can a clinician fully elucidate the multidimensional diagnosis of ALT.
Steroid‐responsive pure red cell aplasia associated with natural killer cell lymphocytosis
Authors: Ayalew Tefferi, Kevin P. Windebank, Michael H. Veeder, Joseph M. Kiely
Journal: American Journal of Hematology (1989)

Abstract A patient with pure red cell aplasia and expansion of the peripheral blood natural killer (NK) cell population is described. Despite normal absolute and differential leukocyte counts, NK cells were increased at diagnosis and at relapse. Furthermore, these cells were not morphologically recognizable on the peripheral blood smear examination. A favorable clinical response to glucocorticoid therapy was accompanied by a decrease in NK cells.
Management of the neck after chemoradiotherapy for head and neck cancers in Asia: consensus statement from the Asian Oncology Summit 2009
Authors: Joseph T Wee, Benjamin O Anderson, June Corry, Anil D'Cruz, Khee C Soo, Chao-Nan Qian, Daniel T Chua, Rodney J Hicks, Christopher HK Goh, James B Khoo, Seng C Ong, Arlene A Forastiere, Anthony T Chan
Journal: The Lancet Oncology (2009)
Sustained release of nanosized complexes of polyethylenimine and anti-TGF-β2 oligonucleotide improves the outcome of glaucoma surgery
Authors: Ana L. Gomes dos Santos, Amélie Bochot, Aoife Doyle, Nicolas Tsapis, Juergen Siepmann, Florence Siepmann, Jeannette Schmaler, Madeleine Besnard, Francine Behar-Cohen, Elias Fattal
Journal: Journal of Controlled Release (2006)
Lung Water in Patients with Acute Myocardial Infarction
Authors: THEODORE L. BIDDLE, PURSHOTTAM K. KHANNA, PAUL N. YU, MORRISON HODGES, PRAVIN M. SHAH
Journal: Circulation (1974)

Pulmonary extravascular water volume (PEV) or lung water was measured in 45 patients with acute myocardial infarction, utilizing the double radioisotope indicator dilution technique. A PEV greater than the upper limit or normal (120 ml/m 2 ) was found in 27 patients, 23 of whom had an elevated pulmonary wedge or pulmonary artery diastolic pressure. A significant correlation was found between PEV and pulmonary wedge or pulmonary diastolic pressure in the whole series. A progressive increase in average PEV was observed from Class I (uncomplicated) to Class IV (shock) patients. There was also a progressive increase in PEV from patients with normal chest X-ray findings to those with radiologic evidence of acute pulmonary edema. In seven of 11 patients with initial elevation of both PEV and pulmonary wedge pressure, repeat determinations demonstrated a substantial reduction in both parameters over a period of 2-4 days. We postulate that an increased PEV in patients with acute myocardial infarction is largely due to an elevated pulmonary capillary pressure. The latter is probably a consequence of an elevated left ventricular diastolic pressure, which may be a manifestation of either left ventricular failure or a decrease in left ventricular compliance.
Physical Examination Skills of US and International Medical Graduates
Authors: Philip O. Ozuah, Jane Curtis, Eugene Dinkevich
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictors of Pain Control in Patients Undergoing Flexible Bronchoscopy
Authors: NOAH LECHTZIN, HAYA R. RUBIN, MOLLIE JENCKES, PETER WHITE, LI-MING ZHOU, DAVID A. THOMPSON, GREGORY B. DIETTE
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The purpose of this study was to assess the extent to which patients undergoing flexible bronchoscopy (FOB) experience pain and to identify patient factors and process of care factors that are associated with pain. We conducted a prospective cohort study on 481 patients undergoing FOB. Overall control of pain during FOB was the primary outcome. The mean age of the patients was 48 yr, 50% were male, and 32% required supplemental oxygen prior to FOB. Pain control was excellent in 36% of patients, but 10% considered it to be fair or poor. Patient factors associated with excellent pain control were excellent health (versus poor health, OR = 6.25 [95% CI, 2.28–16.67]), more education (college education versus high school education, OR = 1.72 [95% CI, 1.05–2.86]), and not having asthma (OR = 2.86 [95% CI, 1.09–7.14]). Process of care factors associated with excellent pain control were not being bothered by scope insertion (versus bothered, OR = 3.65 [95% CI, 1.99–6.98]), no memory of FOB (versus some memory, OR = 2.33 [95% CI, 1.24–4.44]), and higher ratings of information about the procedure (per 1-point increase on a 12-point scale, OR = 1.57 [95% CI, 1.41–1.78]). This is the first large-scale, prospective study to evaluate patient and process of care factors that influence pain control during FOB. It demonstrated that there are patient characteristics and process of care factors that need to be considered when evaluating pain during bronchoscopy. Improved preparation of patients with lower education, inferior health status, and asthma may lead to decreased pain during FOB. Bronchoscopists may be able to reduce pain during FOB by identifying methods to decrease pain on scope insertion, by improving the information provided to patients, and by achieving greater levels of amnesia during FOB.
Primary Care Medicine Recommendations for PDA [CD-ROM]
Authors: Robert Badgett
Journal: Annals of Internal Medicine (2002)

Medical Writings: Book Notes15 October 2002Primary Care Medicine Recommendations for PDA [CD-ROM]Robert Badgett, MDRobert Badgett, MDAssociate Editor for Electronic Publication, Annals of Internal Medicine; University of Texas Health Science Center at San Antonio, San Antonio, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-8-200210150-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Goroll AH and Mulley AG. Philadelphia: Lippincott Williams & Wilkins; 2002. $49.95. ISBN 0781734908. Order at www.lww.com.Field of medicine: Primary care.Format: CD-ROM.System requirements: Handheld devices with Palm, Windows CE, or Windows Pocket PC operating system. Uses 899 K of memory.Audience: Primary care providers.Purpose: To provide a practical reference for primary care.Content:Primary Care Medicine Recommendations (PCMR) is a PDA port of Goroll and Mulley's book, Primary Care Medicine Recommendations (Lippincott Williams & Wilkins, 2001); both are companions to the well-known book, Primary Care Medicine: Office Evaluation and Management of the Adult Patient (Lippincott Williams & ... Author, Article, and Disclosure InformationAffiliations: Associate Editor for Electronic Publication, Annals of Internal Medicine; University of Texas Health Science Center at San Antonio, San Antonio, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 2002Volume 137, Issue 8Page: 706KeywordsACE inhibitorsElderlyHipHip fracturesHypertensionLongitudinal studiesMemoryPatent ductus arteriosusPopulation statisticsSoftware tools ePublished: 15 October 2002 Issue Published: 15 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Photopenic Area Visualized on Bone Scintigraphy in a Patient With Eosinophilic Granuloma
Authors: KOICHIRO AYABE, KOTARO HIGASHI, MANABU OGUCHI, MITSURU TANIGUCHI, YUKIKO MOTOMURA, HISAO TONAMI, TETSURO OKIMURA, ITARU YAMAMOTO, JUNKO NIIMURA, EIKAN KOH
Journal: Clinical Nuclear Medicine (1999)

A 2-year-old boy was evaluated at the authors' institution for an episode of right shoulder pain. Radiographs showed osteolytic changes in the right humerus, and his bone scintigram showed abnormal accumulation with a photon-deficient area in the right humerus. Histologic findings of a bone biopsy revealed no malignant cells. The patient was diagnosed with osteomyelitis and followed accordingly. One month later, he could neither walk nor sit down. At that time his thoracic CT revealed an osteolytic mass in the tenth thoracic vertebra, and his bone scintigram showed a cold defect at the same location. Exploratory surgery was performed, and histologic findings revealed eosinophilic granuloma of the thoracic spine.
669 Characterization of the A549 β-adrenoceptor (βAR) regulating protein components of lymphocyte conditioned medium (LCM) of IM9 cells
Authors: S ROBICSEK, O HEIM, S REINER, J HACKNEY, J ZORITY, R LOCKEY, A SZENTIVANYI
Journal: Journal of Allergy and Clinical Immunology (1991)
CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59
Authors: Josée Golay, Manuela Lazzari, Valeria Facchinetti, Sergio Bernasconi, Gianmaria Borleri, Tiziano Barbui, Alessandro Rambaldi, Martino Introna
Journal: Blood (2001)
Hydroxyisohexyl 3-cyclohexene carboxaldehyde allergy: relationship between patch test and repeated open application test thresholds
Authors: L.A. Fischer, T. Menné, C. Avnstorp, G.B. Kasting, J.D. Johansen
Journal: British Journal of Dermatology (2009)

Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) is a synthetic fragrance ingredient. Case reports of allergy to HICC appeared in the 1980s, and HICC has recently been included in the European baseline series. Human elicitation dose-response studies performed with different allergens have shown a significant relationship between the patch-test threshold and the repeated open application test (ROAT) threshold, which mimics some real-life exposure situations. Fragrance ingredients are special as significant amounts of allergen may evaporate from the skin.The study aimed to investigate the relationship between elicitation threshold doses at the patch test and the ROAT, using HICC as the allergen. The expected evaporation rate was calculated.Seventeen HICC-allergic persons were tested with a dilution series of HICC in a patch test and a ROAT (duration up to 21 days). Seventeen persons with no HICC allergy were included as control group for the ROAT. Results The response frequency to the ROAT (in microg HICC cm(-2) per application) was significantly higher than the response frequency to the patch test at one of the tested doses. Furthermore the response rate to the accumulated ROAT dose was significantly lower at half of the doses compared with the patch test. The evaporation rate of HICC was calculated to be 72% over a 24-h period.The ROAT threshold in dose per area per application is lower than the patch test threshold; furthermore the accumulated ROAT threshold is higher than the patch test threshold, which can probably be explained by the evaporation of HICC from the skin in the open test.
Adverse Effects of Sodium Colistimethate
Authors: ARTHUR D. FLANAGAN
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 January 1971Adverse Effects of Sodium ColistimethateARTHUR D. FLANAGAN, M.D.ARTHUR D. FLANAGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-1-143 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have read the paper on sodium colistimethate by Dr. Koch-Weser in the June issue of the ANNALS (72:857-868, 1970). The report raises certain questions.A prospective study of this nature tends to promise a more comprehensive evaluation of relevant patient data than a retrospective review. Thus, is it consistent with this expectation to present asresultsthe statement from a prospective study: "Autopsies were performed after 22 of the 32 deaths that followed an adverse reaction to colistin. In 13 (4.5%) of the 288 colistin-treated patients clinical and pathological evidence suggested that adverse effects of this... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Warner-Chilcott Laboratories Morris Plains, N. J. 07950 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPolymyxins for the treatment of lower respiratory tract infections: lessons learned from the integration of clinical pharmacokinetic studies and clinical outcomesQuantification of airborne dust, endotoxins, human pathogens and antibiotic and metal resistance genes in Eastern Canadian swine confinement buildingsClinical and microbiological efficacy and toxicity of colistin in patients infected with multidrug-resistant gram-negative pathogensAcinetobacter baumannii : Emergence of a Successful PathogenAerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: A prospective studyToxicity after prolonged (more than four weeks) administration of intravenous colistin 1 January 1971Volume 74, Issue 1Page: 143-144KeywordsAdverse reactionsAutopsyMotivationProspective studiesSodium Issue Published: 1 January 1971 PDF DownloadLoading ...
Familial breast cancer: summary of updated NICE guidance
Authors: D. G. Evans, J. Graham, S. O'Connell, S. Arnold, D. Fitzsimmons
Journal: BMJ (2013)

Familial breast cancer occurs in people with one or more family members affected by breast, ovarian, or a related cancer such as primary peritoneal cancer. About 5% of all breast cancers can be attributed to inherited mutations in specific high risk genes such as BRCA1, BRCA2, and TP53. This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE) on the classification and care of people at risk of familial breast cancer.1 The guideline updates previous NICE guidance on familial breast cancer, published in 2004 and 2006.2 3 It also provides new guidance on men and women with a newly or previously diagnosed breast cancer who have a family history of breast and ovarian cancer, as they were excluded from previous guidance.4 NICE recommendations are based on systematic reviews of the best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the Guideline Development Group's experience and opinion of what constitutes good practice. Evidence levels for the recommendations are given in italic in square brackets. ### Information and support for patients ### Initial assessment in primary care for people without a personal history of breast cancer
THE RÓLE OF STREPTOCOCCI IN EXPERIMENTAL POLIOMYELITIS OF THE MONKEY
Authors: Perrin H. Long, Peter K. Olitsky, Fred W. Stewart
Journal: The Journal of Experimental Medicine (1928)

It is the opinion of Bull, that the streptococci recovered from poliomyelitic tissues, while having no etiological or pathological relationship to the virus of poliomyelitis, occur as secondary invaders in the disease. Smillie and Amoss indicated that the bacteria may be agonal invaders. The results of the experiments reported in this paper point to another source of the streptococci. They occur as contaminants which are introduced into the cultures during the process of grinding tissues. The source of the streptococcus may therefore be the air of the place in which the cultures are made. We have come to this conclusion because first, the tissues of which cultures yielded streptococci were derived from a number of monkeys with experimental poliomyelitis still in a vigorous state. Secondly, when the tissues were ground bacteria were noted much more frequently in their cultures than in those in which fragments of the same brains were used. Thirdly, microorganisms occurred more often in cultures made in the routine laboratory than in a special room where asepsis was carried to the extreme of a major surgical operation on man. Fourthly, streptococci were obtained from the air of the places where cultures were made. Finally, there is no correlation between the cultures of two portions of the same brain. The streptococci occurred in some cultures in pure growth and in others admixed with other ordinary species of bacteria. The latter were often found, in turn, in pure culture and what applies to streptococci, as mentioned in the preceding paragraph, applies equally to the staphylococci, diphtheroids, spore-bearing rods, and other miscellaneous, familiar microorganisms. We could not determine that there exists any etiological relation of the streptococci to poliomyelitis. The fermentation reactions of the microorganisms obtained from the air, from non-poliomyelitic and poliomyelitic monkey brains indicate that bacteria from any of these sources are markedly different. So also with the serological reactions of agglutination and precipitation. Furthermore no agglutination was observed when the serum of monkeys convalescent from experimental poliomyelitis was mixed with any of the streptococci recovered or those received directly or indirectly from Rosenow. Moreover, the intracerebral injection with cultures, irrespective of their source, induced in rabbits a purulent type of meningoencephalitis, often associated with streptococcic septicemia. This result is at marked variance with any known effects of the true filtrable virus of poliomyelitis in man and in the monkey.
Abstract P4-15-07: MicroRNA signature of breast cancer brain metastasis for novel targeted therapies
Authors: S Sethi, A Ahmad, R Ali-Fehmi, S Mittal, G Dyson, F Sarkar
Journal: Cancer Research (2013)

Abstract Rationale: MicroRNAs (miRNAs) are recently described novel small non-coding endogenous RNAs which critically regulate cancer progression, invasion and metastasis. Altered expression of miRNAs has been proposed to control the invasive capability of cancer cells. Modulating altered miRNAs is a novel approach for targeted therapy for cancer. Breast cancer is the most common cancer among women in the US. Breast cancer-related mortality and morbidity are primarily due to metastatic disease especially brain metastasis which also impacts patients’ quality of life. Molecular mechanisms of brain metastasis of breast cancer are largely unknown. Study Objectives: Identifying molecular miRNA signatures in breast cancers which metastasize to the brain can assist in designing novel targeted therapies to prevent and eliminate brain metastasis. Design: RNA was extracted from formalin fixed paraffin embedded tumor tissues from a cohort of breast cancer patients with brain metastasis, and age, stage and follow-up matched breast cancer cases without brain metastasis. miRNA expression profiling was done using EQIXON microarray. Quantitative real-time PCR (qRT-PCR) was used to validate abnormal expression of miRNAs. Data was statistically analyzed using Kruskal-Wallis test to determine the clinical significance of the findings. Results: Over 2000 unique miRNA sequences were profiled in each case. The upregulated miRNAs included miR-3927-5p, miR-216b and miR-10b and the down regulated miRNAs were miR-4280, miR-3174 and miR-1244 and miR20b. Validation of the deregulated miRNAs by q RT-PCR showed statistically significant difference in the expression levels in the breast cancers with brain metastasis compared to breast cancers without brain metastasis (Kruskal-Wallis test; p &amp;lt; 0.001). Conclusions: A unique set of miRNAs were deregulated in breast cancers with brain metastasis. This panel of altered miRNAs have clinical relevance since they can be silenced by antagomirs (chemically modified anti-miRNA oligonucleotides) to treat and prevent brain metastasis. These molecular microRNA signature-based novel targeted prophylactic and therapeutic strategies could improve patients’ quality of life and overall survival in the era of personalized and precision medicine. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-15-07.
High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias
Authors: S Morisot, A S Wayne, O Bohana-Kashtan, I M Kaplan, C D Gocke, R Hildreth, M Stetler-Stevenson, R L Walker, S Davis, P S Meltzer, S J Wheelan, P Brown, R J Jones, L D Shultz, C I Civin
Journal: Leukemia (2010)

In order to develop a xenograft model to determine the efficacy of new therapies against primary human precursor-B acute lymphoblastic leukemia (ALL) stem cells (LSCs), we used the highly immunodeficient non-obese diabetic (NOD).Cg-PrkdcscidIL2rgtmlWjl/SzJ (NOD-severe combined immune deficient (scid) IL2rg−/−) mouse strain. Intravenous transplantation of 2 of 2 ALL cell lines and 9 of 14 primary ALL cases generated leukemia-like proliferations in recipient mice by 1–7 months after transplant. Leukemias were retransplantable, and the immunophenotypes, gene rearrangements and expression profiles were identical or similar to those of the original primary samples. NOD-scid mice transplanted with the same primary samples developed similar leukemias with only a slightly longer latency than did NOD-scid-IL2Rg−/− mice. In this highly sensitive NOD-scid-IL2Rg−/−-based assay, 1–100 unsorted primary human ALL cells from five of five tested patients, four of whom eventually experienced leukemia relapse, generated leukemias in recipient mice. This very high frequency of LSCs suggests that a hierarchical LSC model is not valuable for poor-outcome ALL.