tbuckley/cabot-search huggingface dataset:
NAEVUS ACNEIFORMIS UNILATERALIS
Authors: S. B. SELHORST
Journal: British Journal of Dermatology (1896)

THE case, of which the photograph is appended, is one of those shown during the sittings of the recent Congress of Dermatology in London.On account of the interest excited among the members when I had the opportunity of demonstrating the patient, and on account of its great rarity, I venture to bring it before the readers of this Journal.The patient is !?A years of age, has always been in good health, does not show any signs of a nervous constitution, and is married.Her mother died of consumption, but her father and brothers are in good health, and there is no evidence of any syphilitic taint in the family history.The affection has existed from birth, and is strictly limited to the left side of the body, occupying a considerable area of the thorax, neck, abdomen, and the arm to the second phalanges, the point at which the sebaceous glands cease.It follows closely in its distribution the courses of tho cutaneous nerves.This can be readily noted on the neck, where it occupies the distribution of the small occipital nerve, and can also be observed on the arm, on the chest, and on the abdomen.The lesions consist of oval spots, which have coalesced, on the chest, beck, and upper part of the arm, so as to form one large patch, on which there are numerous flat scars bounded by raised patches of skin.This large area is dotted over with large, simple, and double comedones, and these are also to be observed on the smell oval spots.Occasional small ulcers are also to be seen resulting from the destruction of tissue following folliculitis and perifolliculitis round the comedones.Microscopic examination has clearly proved that we have to deal with true comedones in the case, as, in addition to the histological structure, the microorganisms described 6 s characteristic of comedones have been seen.These acneiform lesions are caused, in my opinion, by a disturbance of the nutrition of the epidermis, by which undue keratinisation
The effectiveness of primary care based risk stratification for targeted latent tuberculosis infection screening in recent immigrants to the UK: a retrospective cohort study
Authors: Rakesh K Panchal, Ivan Browne, Philip Monk, Gerrit Woltmann, Pranabashis Haldar
Journal: Thorax (2013)

<h3>Background</h3> Most UK tuberculosis (TB) cases occur in immigrants from high TB incidence areas, implicating reactivation of imported latent TB infection (LTBI). Strategies to identify and treat immigrant LTBI in primary care at the time of first registration (coded Flag-4) may be effective. <h3>Methods</h3> This was an 11-year retrospective cohort study to evaluate effectiveness of LTBI screening in recent immigrants to Leicestershire at their time of primary care registration. We examined the temporal relationship between dates of Flag-4 primary care registration (n=59 007) and foreign-born TB (FB-TB) cases (n=857), for immigrants arriving to the UK after 1999. TB diagnosed &gt;6 months after registration was considered potentially preventable with screening. Primary outcomes&nbsp;were the potentially preventable proportion of FB-TB&nbsp;and the number needed to screen (NNS) of immigrants to identify one potentially preventable case, stratified by age and region of origin. <h3>Results</h3> 250 cases (29%) were potentially preventable in Flag-4-registered immigrants. Overall, 511 cases (60%) were potentially preventable among primary-care registered immigrants, implying a significant proportion without Flag-4 status. Prospective TB incidence (95% CI) after Flag-4 registration was 183 (163 to 205) cases/100 000 person-years, with a NNS (95% CI) of 145 (130 to 162). Targeted screening was most effective for 16–35 year olds from TB incidence regions 150–499/100 000 (NNS (95% CI)=65 (57 to 74), preventing 159 (18.7%) cases). Unpreventable TB risk increased with delayed primary care registration after UK entry (p&lt;0.001) and was associated with HIV seropositivity (relative risk (95% CI)=1.89 (1.25 to 2.84), p=0.003). <h3>Conclusions</h3> LTBI screening at primary care registration offers an effective strategy for potentially identifying immigrants at high risk of developing TB.
Lymphocyte Surface Markers
Authors: R. A. Good
Journal: New England Journal of Medicine (1972)

Great progress has been made in recent years toward a definition of the separate origin and separate function of different cell populations in lymphoid tissues.1,2 From these studies it has become clear that among the large, medium, and small lymphocytes of the peripheral blood, not one but several separable lymphocyte populations exist. For example, T-lymphocytes, B-lymphocytes, lymphocyte-like precursors of monocytes (M-cells), multipotential stem cells (S-cells) and committed stem cells of different cell lines (S1, S2, S3, S4) can be identified among the population of cells that are morphologically grouped as lymphocytes of . . .
Quantitative Analysis of Transgene Protein, mRNA, and Vector DNA Following Injection of an Adenoviral Vector Harboring Glial Cell Line-Derived Neurotrophic Factor into the Primate Caudate Nucleus
Authors: Dorothy A. Kozlowski, Eric Bremer, D.Eugene Redmond, David George, Beth Larson, Martha C. Bohn
Journal: Molecular Therapy (2001)

Gene therapy for neurodegenerative diseases relies on stable expression of a vector-mediated transgene in the human central nervous system (CNS). In nonhuman primate CNS, transgene expression has been primarily assessed using descriptive histological methods. Here, we quantified the expression of a human glial cell line-derived neurotrophic factor (hGDNF) transgene using an ELISA specific for hGDNF protein and real-time quantitative RT-PCR and PCR for hGDNF mRNA and vector DNA, respectively. Transgene expression was assessed 1 week after injection of an E1-, E3-deleted adenovirus harboring hGDNF into the caudate nucleus of St. Kitts green monkey. We found that 57–147 million and 116–771 million copies of hGDNF mRNA and vector DNA, respectively, were present per 10,000 copies of the β-actin gene. In the same sites, 40–152 pg of hGDNF protein per milligram of tissue was measured. Comparisons of these measures among monkeys demonstrated variable vector DNA and protein levels, but consistent mRNA levels at one-third of the level of vector DNA. This suggests that local responses to the vector play a role in the level of transgene expression and that high levels of vector DNA do not necessarily predict a high level of transgene protein. However, the results of this study do show that neuroprotective levels of GDNF transgene expression can be achieved following injection of an adenoviral vector into nonhuman primate caudate. Moreover, these assays provide quantitative methods for evaluating and comparing viral vectors in primate CNS.
Memory, imagination, and the asymmetry between past and future
Authors: Bjorn Merker
Journal: Behavioral and Brain Sciences (2007)

Abstract A number of difficulties encumber the Suddendorf &amp; Corballis (S&amp;C) proposal regarding mental time travel into the future. Among these are conceptual issues turning on the inherent asymmetry of time and causality with regard to past and future, and the bearing of such asymmetry on the uses and utility of retrospective versus prospective mental time travel, on which I comment.
Acute Poisoning Caused by Tinned Ox Tongue
Authors: E. Gwynn
Journal: BMJ (1892)

advanced period of life is of necessity more or less inefficient, and any inducement for a medical practitioner to continue in office under such circumstances by the fear of a pension not being granted on resignation is without doubt seriously disadvantageous not only to the ratepayers but specially so to the sick poor.COMPULSORY MEDICAL CERTIFICATION OF CAUSE OF DEATH.No greater mistake in legislation was, in the opinion of many Poor-law medical officers, ever made than when, following the Scotch example, this became compulsory in England.Cases are constantly met withi in practice where the medical officer is called in just previous to death, not really to give medical attendance, but to give the neces- sary certificate after death.It is now very difficult for him to refuse, and so, rather than face a coroner's jury, with the liability to censure, if sufficient cause of death is established by post-mortem examination, the certificate is often given.Formerly, when this was optional, much good resulted from the refusal to give it.The idea is now very prevalent that the required certificate must be given, and this idea is not far from being correct.
Effects of manufacturing oral contraceptives on blood clotting.
Authors: L Poller, J M Thomson, K F Yee
Journal: BMJ (1979)

In monitoring the effects of industrial exposure resulting from the pharmaceutical manufacture of oestrogen-progestogen combinations by coagulation studies acceleration of some clotting tests was found. The most pronounced changes were in workers most closely associated with the industrial process. Less pronounced changes were found in women employees not closely concerned with the processing and may have been secondary to the postmenopausal bleeding to which they were prone. A safer work procedure elaborated by the Employment Medical Advisory Service was monitored by clotting studies for over a year but the three most highly exposed subjects showed no substantial improvement.
1157-46 Hemodynamic impairment of intermediate stenoses in saphenous vein coronary artery bypass grafts and recipient vessels: Evaluation by doppler flow velocity
Authors: Liesbeth P Salm, Wouter Jukema, Susan E Langerak, Hubert W Vliegen, Paul Steendijk, Aeilko H Zwinderman, Jeroen J Bax, Hildo J Lamb, Albert De Roos, Ernst E Van der Wall
Journal: Journal of the American College of Cardiology (2004)
Breast-feeding in the Oxford Child Health Survey
Authors: A. Stewart, C. Westropp
Journal: BMJ (1953)

In a recent paper some of the social and biological factors which influenced the breast-feeding habits of mothers in the Oxford Child Health Survey were dis- cussed (Westropp, 1953).It remains to discover what special advantages, if any, were enjoyed by-the breastfed babies.In the following account the change-over from breastfeeding to artificial feeding is referred to as the weaning period.In a few cases complete breast-feeding was never established, but for most of the babies three distinct modes of feeding were represented in the first year: (1) Complete breast-feeding or pre-weaning period: during this phase the only additions to a diet of breast milk were vitamin concentrates.(2) Mixed feed- ing or weaning period: during this phase the babies were receiving breast milk and other liquid or solid foods:(3) " Other " feeding or post-weaning period: this phase began when the baby ceased to have any breast milk.Growth and Development For 142 of the 580 babies who remained in the Survey for a year, weaning began during the first month (group 1), and for 235 it was postponed for at least five months (group 4).In addition, there were 84 babies who began to be weaned in the second or third month (group 2) and 119 in the fourth or fifth month (group 3).The composition of these four feeding groups in respect of sex, parity, birth- weight, and parents' weights is shown in Table I.These TABLE .-Sex,Parity, Birth Weight, and Parental Weights of Four Groups of Babies Defined by Duration of Complete Breast-feeding Age in Avere Aver .gWeight Feed-Months at N.f y ?Brt (lb.)oGoup Pnse Babies Boys born
Reporting provocative results. Can we publish 'hot' papers without getting burned?
Authors: J. L. Mills
Journal: JAMA (1987)

IN APRIL 1981,<i>JAMA</i>published an article reporting an association between spermicide use around conception and congenital disorders.<sup>1</sup>The authors were careful to note that "the results should be considered tentative until confirmed by other data." Nevertheless, their findings were taken up by the media and lawyers and treated as if they were established facts. Pregnant women who had used spermicides around conception became alarmed, and spermicide manufacturers were sued by former users who had had malformed infants. Some journals publish exciting positive findings but are loathe to publish subsequent negative investigations that contradict them.<i>JAMA</i>, to its credit, published an editorial the following year explaining why the association should be considered tentative or preliminary,<sup>2</sup>along with several studies<sup>3,4</sup>that did not find any association between spermicides and birth defects. Subsequently, a number of negative studies appeared in other journals,<sup>5</sup>and Food and Drug Administration hearings
Cardiff dean is exonerated after claims that his team manipulated images in research papers
Authors: C. Dyer
Journal: BMJ (2013)

The Breathing Space Clinic: a multi-disciplinary, inter-organisational hospice-based pilot clinic to support the holistic needs of patients with advanced chronic obstructive pulmonary disease (COPD). Introduction: In contrast to many other conditions, mortality trends indicate that the prevalence of COPD is increasing. Studies show that COPD patients9 symptoms are at least as severe as those of patients with lung cancer and that this group is underserved by specialist palliative care. There are currently no reliable means of identifying when COPD patients enter their last year of life. Breathing Space combines the specialist expertise of both COPD-specific and palliative care teams to provide information, non-pharmacological and pharmacological interventions, advance care planning etc. The clinic thus aims to maximise quality of life for patients with very severe disease in response to need rather than prognosis. <h3>Aims</h3> This presentation will outline the development and function of the Breathing Space Clinic, focusing on the rationale for our referral criteria and pathway. <h3>Methods</h3> Clinic development involved collaboration between the hospice, COPD patients, primary care teams and specialist respiratory teams across three London boroughs. It targets those patients with very severe COPD who have complex needs, including those arising from co-morbidities. Referral criteria are designed to reflect this approach and are grounded in an alternative model to that of palliative care provision for cancer patients. The referral pathway is designed to ensure NICE compliance. Relevant metrics are collected. <h3>Results</h3> Our presentation will include reflection upon early data from the pilot. <h3>Discussion</h3> Significant time and multi-disciplinary effort was required to develop the clinic concept to an operational level. Challenges were encountered in developing explicit referral criteria and these will be reviewed in light of the clinic metrics. <h3>Conclusion</h3> Collaborative interventions have potential to greatly improve patient care but require commitment and learning from all involved.
Markers of Coronary Disease
Authors: Joon Sup Lee
Journal: Annals of Internal Medicine (1991)

Letters15 August 1991Markers of Coronary DiseaseJoon Sup Lee, MDJoon Sup Lee, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-4-327 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In their recent paper, Miranda and colleagues (1) assert that ST-segment changes are more reliable markers of coronary artery disease than is exercise-induced angina. The validity of this conclusion relies, however, on the assumption that their study sample is representative of all patients undergoing exercise tests. Given the method in which the study sample was chosen, it is unlikely that this assumption is a valid one.Of 3047 patients having exercise testing in their institution, only 30% had coronary angiography. Because this 30% was not selected at random for the purposes of this study, these patients might...Reference1. MirandaLehmannLachtermanCoodleyFroelicher CKBEV. Comparison of silent and symptomatic ischemia during exercise testing in men. Ann Intern Med. 1991;114:649-56. LinkGoogle Scholar1. MirandaLehmannLachtermanCoodleyFroelicher CKBEV. Comparison of silent and symptomatic ischemia during exercise testing in men. Ann Intern Med. 1991;114:649-56. LinkGoogle Scholar2. Diamond G. Reverend Bayes' silent majority. An alternative factor affecting sensitivity and specificity of exercise electrocardiography. Am J Cardiol. 1986;57:1175-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital Boston, MA 02114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1991Volume 115, Issue 4Page: 327-328KeywordsAnginaAngiographyCoronary arteriesExercisePatient advocacyStable coronary artery disease Issue Published: 15 August 1991 PDF DownloadLoading ...
Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors
Authors: X Zhang, T Inukai, K Hirose, K Akahane, I Kuroda, H Honna-Oshiro, K Kagami, K Goi, K Nakamura, M Kobayashi, M Endo, H Yagita, H Kurosawa, A Thomas Look, H Honda, T Inaba, S Nakazawa, K Sugita
Journal: Leukemia (2012)
Prevalence of nonviable myocardium in the inferolateral wall in potential candidates for biventricular pacing and underlying coronary artery disease
Authors: Olivier De Winter, Johan De Sutter, Geert Van Pottelbergh, Frederic Van Heuverswyn, Rudi A. Dierckx, Thierry Gillebert
Journal: Journal of the American College of Cardiology (2003)
Determinants of Exercise Capacity in Patients With Type 2 Diabetes
Authors: Zhi You Fang, James Sharman, Johannes B. Prins, Thomas H. Marwick
Journal: Diabetes Care (2005)

OBJECTIVE—Type 2 diabetes is associated with reduced exercise capacity, but the cause of this association is unclear. We sought the associations of impaired exercise capacity in type 2 diabetes. RESEARCH DESIGN AND METHODS—Subclinical left ventricular (LV) dysfunction was sought from myocardial strain rate and the basal segmental diastolic velocity (Em) of each wall in 170 patients with type 2 diabetes (aged 56 ± 10 years, 91 men), good quality echocardiographic images, and negative exercise echocardiograms. The same measurements were made in 56 control subjects (aged 53 ± 10 years, 29 men). Exercise capacity was calculated in metabolic equivalents, and heart rate recovery (HRR) was measured as the heart rate difference between peak and 1 min after exercise. In subjects with type 2 diabetes, exercise capacity was correlated with clinical, therapeutic, biochemical, and echocardiographic variables, and significant independent associations were sought using a multiple linear regression model. RESULTS—Exercise capacity, strain rate, Em, and HRR were significantly reduced in type 2 diabetes. Exercise capacity was associated with age (r = −0.37, P &amp;lt; 0.001), male sex (r = 0.26, P = 0.001), BMI (r = −0.19, P = 0.012), HbA1c (A1C; r = −0.22, P = 0.009), Em (r = 0.43, P &amp;lt; 0.001), HRR (r = 0.42, P &amp;lt; 0.001), diabetes duration (r = −0.18, P = 0.021), and hypertension history (r = −0.28, P &amp;lt; 0.001). Age (P &amp;lt; 0.001), male sex (P = 0.007), BMI (P = 0.001), Em (P = 0.032), HRR (P = 0.013), and A1C (P = 0.0007) were independent predictors of exercise capacity. CONCLUSIONS—Reduced exercise capacity in patients with type 2 diabetes is associated with diabetes control, subclinical LV dysfunction, and impaired HRR.
Pregnancy Following Double Ovariotomy.
Authors: R. L. Larsen
Journal: JAMA (1904)

Chicago, June 26, 1904. <h3>To the Editor:</h3> —Having read the report of I. W. Hunter's article on "Pregnancy Following Double Ovariotomy," in the<i>Medical Age</i>, Detroit, of recent date, I can not resist the temptation to offer my opinion as explaining the phenomenon of fecundation of an ovum, after extirpation of ovaries and tubes in a given case. We know from experience that pregnancy can and does take place in a woman who has had performed ovariectomy and salpingectomy, unilateral or bilateral. We know that cases such as this have occurred where a woman has conceived and become pregnant after having but one single congress with her husband, as the sailor who had to leave home immediately after his marriage. This statement, at first sight, may seem to have no bearing on the subject at issue, but before concluding the reader will see its connection. We know that after the
His Bundle Electrograms in Two Cases of Wolff-Parkinson-White (Pre-excitation) Syndrome
Authors: AGUSTIN CASTELLANOS, EDUARDO CHAPUNOFF, CESAR CASTILLO, ORLANDO MAYTIN, LOUIS LEMBERG
Journal: Circulation (1970)

The catheter technic for recording the electrical activity of the specialized conducting system in the human heart showed in two patients studied that ventricular pre-excitation was apparently due to a bypass of the His bundle. Intermediate forms of WPW complexes appeared to be combination beats resulting from the activation of the ventricles through impulses traversing both the His bundle and accessory communications. Preferential iatrogenic activation of an intra-atrial (and perhaps even of an atrioventricular) tract appeared to occur in one of the patients. The patients with the WPW (pre-excitation) syndrome and long histories of paroxysmal arrhythmias were successfully treated with a combination of oral propranolol and implanted (transvenous) demand pacemaker.
Labour fudge on fundholding
Authors: J. Warden
Journal: BMJ (1997)

The future of GP fundholding remains in the balance if a Labour government is elected in Britain on 1 May.

In contrast to previous commitments to “abolish” or “replace” fundholding, the Labour party manifesto is non-committal, promising only to “remove the disadvantages that have come from the present system” and proceed with locality commissioning.

But, having diluted that commitment, Labour strengthens another on funding. It now matches the Conservatives …
Arteriosclerotic Abdominal Aortic Aneurysm
Authors: Tung K. Lin
Journal: JAMA (1963)

RUPTURE of an arteriosclerotic abdominal aneurysm into the inferior vena cava is unusual. The first antemortem diagnosis was made in Chile by Dussaillant and his associates, in 1949, on a 62-year-old hypertensive woman who died 70 days after the onset of acute symptoms.1There have been 14 patients diagnosed antemortem1-13and 10 patients on whom successful surgical treatment has been carried out.3,4-6, 8, 9,11-13This paper presents an unusual manifestation of the central nervous system during this cardiovascular catastrophe.  Report of a Case  A 60-year-old white male was admitted to St. Luke's Hospital on May 19, 1951, with sudden generalized weakness, semistupor, mild mental confusion, and vomiting of 3 hours' duration. His recent health had been good and there was no history of abdominal pain or cardiovascular disease.  Initial examination at home revealed a pallid, asthenic, cooperative, but confused, man able to walk with help. His skin