The Sweet Syndrome during Therapy with Granulocyte Colony-stimulating Factor
Authors: John W. Park, Bhoomi Mehrotra, Bryan O. Barnett, Ari D. Baron, Alan P. Venook
Journal: Annals of Internal Medicine (1992)

Brief Reports15 June 1992The Sweet Syndrome during Therapy with Granulocyte Colony-stimulating FactorJohn W. Park, MD, Bhoomi Mehrotra, MD, Bryan O. Barnett, MD, Ari D. Baron, MD, Alan P. Venook, MDJohn W. Park, MD, Bhoomi Mehrotra, MD, Bryan O. Barnett, MD, Ari D. Baron, MD, Alan P. Venook, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-12-996 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGranulocyte colony-stimulating factor (G-CSF; filgrastim), a hematopoietic growth factor that promotes the proliferation and differentiation of neutrophils, is an important new adjunct to cancer chemotherapy. It is effective in lessening the degree and duration of neutropenia and is usually well tolerated. We report a case of the Sweet syndrome that developed during G-CSF therapy in a woman with breast cancer who was undergoing chemotherapy.Case ReportA 41-year-old woman receiving chemotherapy and G-CSF therapy for breast cancer presented with acute fever and skin rash. Except for recently diagnosed breast cancer, her medical history was unremarkable. The diagnosis of breast cancer...References1. Sweet R. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1864;76:349-56. CrossrefGoogle Scholar2. KemmettHunter DJ. Sweet's syndrome: a clinicopathologic review of twenty-nine cases. J Am Acad Dermatol. 1990;23:503-7. CrossrefMedlineGoogle Scholar3. CohenTalpazKurzrock PMR. Malignancy-associated Sweet's syndrome: review of the world literature. J Clin Oncol. 1988;6:1887-97. CrossrefMedlineGoogle Scholar4. CohenKurzrock PR. Sweet's syndrome and malignancy. Am J Med. 1987;82:1220-6. CrossrefMedlineGoogle Scholar5. MeuldersAllalEggersFerrant QASA. Sweet's syndrome and myelodysplastia syndrome in a patient with metastatic breast carcinoma. Am J Med. 1989;86:138-9. CrossrefMedlineGoogle Scholar6. WakefieldJamesSamlaskaMeltzer PWCM. Colony-stimulating factors. J Am Acad Dermatol. 1990;23:903-12. CrossrefMedlineGoogle Scholar7. GlaspyBaldwinRobertsonSouzaVincentAmbersley JGPLMJ. Therapy for neutropenia in hairy cell leukemia with recombinant human granulocyte colony-stimulating factor. Ann Intern Med. 1988;109:789-95. LinkGoogle Scholar8. CohenKurzrock PR. Diagnosing the Sweet syndrome [Letter]. Ann Intern Med. 1989;110:573-4. LinkGoogle Scholar9. NegrinHaenberNaglerOldsDonlonSouza RDALTL. Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor. Ann Intern Med. 1989;110:976-84. LinkGoogle Scholar10. RossMoyKaplanFiglin HLRR. Bullous pyoderma gangrenosum after granulocyte colony-stimulating factor treatment. Cancer. 1991;68:441-3. CrossrefMedlineGoogle Scholar11. DreicerSchillerCarbone RJP. Granulocyte-macrophage colony-stimulating factor and vasculitis [Letter]. Ann Intern Med. 1989;111:91-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John W. Park, MD; Bhoomi Mehrotra, MD; Bryan O. Barnett, MD; Ari D. Baron, MD; Alan P. Venook, MDAffiliations: From the University of California, San Francisco, San Francisco, California. For current author addresses, see end of text. 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