tbuckley/cabot-search huggingface dataset:
Evidence of reproductive endocrine effects in women with occupational fuel and solvent exposures.
Authors: Susan R Reutman, Grace Kawas LeMasters, Edwin A Knecht, Rakesh Shukla, James E Lockey, G Edward Burroughs, James S Kesner
Journal: Environmental Health Perspectives (2002)

Hydrocarbons (HCs) found in fuels and solvents are ubiquitous in the environment, yet we know little about their effects on the endocrine system. The objective of this study was to assess the potential reproductive endocrine effects of low-dose HCs encountered by female U.S. Air Force personnel with fuel (primarily JP-8 jet fuel) and solvent exposures (n = 63). We estimated the internal dose of HCs in fuels and solvents by measuring their levels in exhaled breath, including the sum of aliphatic HCs (C6H14-C16H34) and the sum of aromatic HCs (benzene, ethylbenzene, toluene, and m,p,o-xylenes). Adverse outcome measures included urinary endocrine markers that have been associated with nonconceptive (vs. conceptive) menstrual cycles in ovulatory women: lower preovulatory luteinizing hormone (LH) and mid-luteal phase pregnanediol 3-glucuronide (Pd3G) and estrone 3-glucuronide, and higher follicle phase Pd3G. We also obtained reproductive and exposure information from baseline questionnaires and daily diaries. Toluene was the most frequently found analyte in the breath, with values up to 52.0 ppb, and benzene breath levels were up to 97.5 ppb. Regression analysis revealed that preovulatory LH levels were significantly lower (p = 0.007) among women whose total aliphatic HC levels were above the median. The relationship between elevated aliphatic HC exposure and lowered preovulatory LH levels in the present study suggests that compounds in fuels and some solvents may act as reproductive endocrine disruptors. Confirmation of these findings is needed, not only to determine if fuel and solvent exposure may impact other LH-dependent physiologic functions but also to examine effects of fuels and solvents on conception.
Immune Aspects of Renal Diseases
Authors: Kenneth P. Mathews
Journal: JAMA (1982)

IMMUNOLOGIC renal injury can be mediated by immune complexes or by free antibody that interacts with native or tissue-bound antigen. <h3>RENAL DISEASE MEDIATED BY IMMUNE COMPLEXES</h3> The most common mechanism of renal injury involves deposition of immune reactants in the kidney. Circulating immune complexes must have certain physical and biologic properties to be able to localize in tissues and cause injury. Complexes of large size, for example, those at equivalence, are poorly soluble and disposed of by cells of the mononuclear-phagocyte system. Complexes of very small size, formed in extreme antigen excess, are soluble and have limited nephrotoxicity because they do not fix complement. Complexes that are formed in slight antigen excess are both soluble and able to fix complement; such complexes may be nephrotoxic. Whenever appropriate antibodies interact with antigen, the complement system may be activated. Activation of the complement system can lead to alterations in vascular permeability (and
Peritoneoscopic Evaluation of the Effect of Chemotherapeutic Agents on Liver Métastases of Breast Cancer*: (Report of 2 Cases)
Authors: H. Bleiberg, M. Rozencweig, D. Gangji, J. Heuson
Journal: Endoscopy (1976)

Two cases of breast cancer are presented in which massive liver metastases were proved by biopsies prior to treatment. Use of alternate cyclical hormonal cytotoxic combination chemotherapy (EORTC Clinical Trial, protocol, no 10741/3) was followed by a dramatic disappearance of neoplastic tissue. Peritoneoscopy associated with needle biopsy proved extremely useful to provide objective evaluation of the response to chemotherapy.
Iron Chelation with Desferrioxamine.
Authors: John R. Walsh
Journal: Annals of Internal Medicine (1964)

s1 April 1964Iron Chelation with Desferrioxamine.John R. Walsh, M.D., F.A.C.P., Robert E. Mass, M.D., Frederic W. Smith, M.D., Verna E. Lange, B.S.John R. Walsh, M.D., F.A.C.P.Search for more papers by this author, Robert E. Mass, M.D.Search for more papers by this author, Frederic W. Smith, M.D.Search for more papers by this author, Verna E. Lange, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-728_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDesferrioxamine (DF), an iron chelating substance, was given parenterally to four patients with idiopathic hemochromatosis, eight patients with cirrhosis of the liver associated with various degrees of iron stores, two patients with hemosiderosis related to blood transfusions, and two control patients. Control patients excreted insignificant amounts of iron in their urine (< 2.0 mg/24 hr), compared with patients with hemochromatosis and hemosiderosis (2.5 to 45 mg/24 hr). Clinical and pathological differentiation of idiopathic hemochromatosis from the hemosiderosis seen with Laennec's cirrhosis was difficult; some patients with the latter exhibited urinary iron excretion patterns similar to patients with hemochromatosis. Therefore, urinary... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 728-728KeywordsBlood transfusionCirrhosisExcretionHemochromatosisLiverUrine Issue Published: 1 April 1964 PDF DownloadLoading ...
Interferon Studies with Japanese and U.S. Rubella Virus Strains
Authors: J. E. Potter, J. E. Banatvala, J. M. Best
Journal: BMJ (1973)

Japanese strains of rubella virus have been claimed not to be teratogenic, and tests on three Japanese strains showed that they induced high levels of interferon in human placental cell cultures obtained from conceptuses ranging from 13 to 24 weeks' gestational age, whereas two strains derived from the U.S.A. induced low levels. Both Japanese and U.S. strains induced similar but low levels in fetal lung cell cultures and leucocyte preparations. A representative Japanese strain and a U.S. strain were both interferon-sensitive. If indeed a strain can be shown to be non-teratogenic it could lead to an alternative, safer rubella vaccine.
Front line musculoskeletal care
Authors: N. J. Snelling
Journal: BMJ (2011)

Having trained as an osteopath and then as a doctor, I agree that training in medical school for the management of back pain is poor1 and that physiotherapists, osteopaths, and chiropractors could provide a useful service to the NHS because they spend much longer studying musculoskeletal pain syndromes.

However, these clinicians are trained …
Diabetic Regimens — Procrustean Beds?
Authors: Maurice B. Strauss
Journal: New England Journal of Medicine (1969)

The isolation of insulin almost 50 years ago and its general availability soon thereafter raised high hopes that death and disability from diabetes mellitus would soon be of historic interest only. Certainly today we can correct the grosser aspects of disordered carbohydrate, fat and mineral metabolism.However, many a patient with juvenile diabetes, although saved by insulin and appropriate metabolic management from inanition, acidosis, coma and death, now suffers — after an average reprieve of 10 to 20 years — from the vascular and other accompaniments of his disease: retinitis, neuropathy and nephropathy. Despite our greatly improved understanding of the . . .
Kaplan–Meier method is inappropriate for estimating cumulative incidence of graft‐versus‐host disease in the presence of competing events
Authors: Marcos B. Viana, Benigna M. Oliveira, Camila S.P. Cancela
Journal: American Journal of Hematology (2010)

Additional Supporting Information may be found in the online version of this article. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Approaches to Breast-Cancer Staging
Authors: Barbara L. Smith
Journal: New England Journal of Medicine (2000)

Each year more than 180,000 women in the United States receive a diagnosis of breast cancer, and over 40,000 of them ultimately die of their disease. Larger primary tumors and tumor cells in axillary nodes are strong predictors of metastatic disease and death. In an effort to prevent these outcomes, women with tumor cells in axillary nodes routinely receive chemotherapy, hormonal therapy, or both, and radiation after surgery. Unfortunately, the predictive value of axillary-node status is limited. As many as 40 percent of women with positive axillary nodes survive 10 years, and metastatic disease develops within 10 years after diagnosis . . .
Premarital Syphilis Serologies-Reply
Authors: Yehudi M. Felman
Journal: JAMA (1979)

I am in complete agreement with Dr Lynfield's reasons for advocating visits to a physician by young couples before marriage. However, mandating a wasteful and cost-ineffective blood test is not the means to accomplish this otherwise desirable goal. It would make more sense to mandate hypertension screening before marriage. The yield in terms of disease control would be far greater than that of premarital syphilis serology. Furthermore, I wonder how the homosexual community can benefit from this emphasis on premarital physical examination. In practice, the premarital syphilis blood test experience is far different for most patients than the picture Dr Lynfield describes. Most physicians do the blood test and little else, despite clear language in the New York State law stating that "a physical examination should include an examination of the external genitalia, of the skin of the entire body including the anal and perianal regions, of the
A CASE OF RUPTURED UTERINE SINUS.
Authors: ANNIE LEE HAMILTON
Journal: JAMA (1907)

The following case occurred during the service of Dr. Franklin G. Balch at the Massachusetts General Hospital. A rather careful search of the literature has failed to reveal a similar case, although it seems probable that the condition may occur in any case in which there are strong adhesions. <h3>Patient.</h3> —N. M., aged 29, married, unipara, a strong young Irish woman, had always been well. <h3>History.</h3> —There was no history of previous illness. The patient was seven months pregnant but menstruation had not ceased during pregnancy. Jan. 31, 1906, the patient entered Boston Lying-in Hospital complaining of much pain and was supposed to be in labor. There was a history of abdominal pain for six weeks, not localized, and not sufficient to cause her to go to bed. The evening before entrance, the pain became very sharp and severe. The abdomen soon became tender and hard, the patient was unable
Judge rules that birth defects could have been caused by toxic waste from steel works
Authors: C. Dyer
Journal: BMJ (2009)

Sixteen young people who claim that their birth defects were caused by a “soup of toxic materials” created when the local council reclaimed the site of the former British Steel works in Corby, Northamptonshire, have scored a landmark victory in the High Court in London.

Mr Justice Akenhead ruled that Corby Borough Council was negligent and in breach of its statutory duty in carrying out the reclamation and that a cluster of limb defects could have been caused by the toxic airborne dust that blanketed the town. …
Lymphadenectomy at the Time of Nephroureterectomy for Upper Tract Urothelial Cancer
Authors: Marco Roscigno, Maurizio Brausi, Axel Heidenreich, Yair Lotan, Vitaly Margulis, Shahrokh F. Shariat, Hendrik Van Poppel, Richard Zigeuner
Journal: European Urology (2011)
Understanding Depression and Distress Among Medical Students
Authors: Laura Weiss Roberts
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABSCESS OF FRONTAL LOBE: OPERATION: RECOVERY
Authors: S. W. Swindells, A. H. Rankin
Journal: BMJ (1924)

E 2imL JoUNTAn examination of the dates of attack in the boys' home shows that Case 1 infected the remaining cases, and that the removal of tlle subsequent cases to a separate dormitory without any special precautions was sufficient to check any further spread of the disease.Althouglh the unprotected were with one exception attacked, yet they were not, as one might expect, attacked first.Cases 7, 8, 9, and 10, who were previously vaccinated, became infected before Cases 11, 12, 13, 14, anid 15, who were not.All the cases were of the mild tv)e, andl tlher-e was Jio practical differenice ill severity betweeii the cases arising amonig the pr-otected andl the unprotected.In the girlls' lhomiie secondary cases were looked for witlh some assurance.Their immuinity was perhaps due to the fact that eachl gir] lihad a separate bed- room.The bovs' home is planned on the dormitoly system.
Gemcitabine treatment in cutaneous T-cell lymphoma: a multicentre study of 23 cases
Authors: K. Jidar, S. Ingen-Housz-Oro, M. Beylot-Barry, C. Paul, D. Chaoui, M. Sigal-Grinberg, P. Morel, L. Dubertret, H. Bachelez
Journal: British Journal of Dermatology (2009)

Journal Article Gemcitabine treatment in cutaneous T‐cell lymphoma: a multicentre study of 23 cases Get access K. Jidar, K. Jidar Service de Dermatologie Search for other works by this author on: Oxford Academic Google Scholar S. Ingen‐Housz‐Oro, S. Ingen‐Housz‐Oro Service de Dermatologie Correspondence: Saskia Ingen‐Housz‐Oro. E‐mail: saskia.oro@hmn.aphp.fr Search for other works by this author on: Oxford Academic Google Scholar M. Beylot‐Barry, M. Beylot‐Barry Service de Dermatologie, CHU Bordeaux, Hôpital Haut‐Lévêque, avenue de Magellan, 33600 Pessac, France Search for other works by this author on: Oxford Academic Google Scholar C. Paul, C. Paul Service de Dermatologie, CHU Toulouse, Hôpital Purpan, place du Docteur Baylac, TSA 40031, 31059 Toulouse cedex 9, France Search for other works by this author on: Oxford Academic Google Scholar D. Chaoui, D. Chaoui Service d'Hématologie, Centre Hospitalier Victor Dupuy, 95100 Argenteuil, France Search for other works by this author on: Oxford Academic Google Scholar M. Sigal‐Grinberg, M. Sigal‐Grinberg Service de Dermatologie Search for other works by this author on: Oxford Academic Google Scholar P. Morel, P. Morel Service de Dermatologie, Hôpital Saint Louis, avenue Claude Vellefaux, 75010 Paris, France Search for other works by this author on: Oxford Academic Google Scholar L. Dubertret, L. Dubertret Service de Dermatologie, Hôpital Saint Louis, avenue Claude Vellefaux, 75010 Paris, France Search for other works by this author on: Oxford Academic Google Scholar H. Bachelez H. Bachelez Service de Dermatologie, Hôpital Saint Louis, avenue Claude Vellefaux, 75010 Paris, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 161, Issue 3, 1 September 2009, Pages 660–663, https://doi.org/10.1111/j.1365-2133.2009.09230.x Published: 01 September 2009
Inflammatory Fibroid Polyp of the Small Intestine
Authors: Monica Huszar
Journal: JAMA (1980)

To the Editor.—  Inflammatory fibroid polyp of the gastrointestinal tract is a rare benign lesion, usually located in the stomach. To our knowledge, only 24 cases have been described in the ileum. 1 Because of easy confusion with a malignant neoplasm, a correct diagnosis is important. Recently we treated a patient for acute small-bowel obstruction caused by such a lesion.  Report of a Case.—  A 78-year-old woman was admitted to the hospital because of acute abdominal pain and vomiting of 24 hours' duration. Her past history was noncontributory. She was in good general condition, with a pulse of 72 beats per minute and regular, and blood pressure of 120/80 mm Hg. The abdomen was distended and tender with hypoactive peristaltic sounds. The WBC count was 8,200/cu mm, with a normal differential cell count. Abdominal roentgenograms showed distention of the ileum with air-fluid levels. Results of the barium enema examination were
Prolonged Wound Analgesia after Surgical Operations
Authors: H. L. M. Roualle
Journal: BMJ (1952)

By the morning of May 26 the patient was able to open her mouth a little wider.At 11 p.m. she was found to be perspiring freely, the respiration was gasping in character, and her muscles were extremely relaxed, so the drip was stopped, and by 1 a.m.she was quite comfortable.The next morning she was breathing without difficulty and no sign of muscle spasm remained: she was alert after a very restful night.No further gallamine was required.On May 28 she was able to eat solid food.Although muscle tone remained increased, no further spasms occurred.Respiratory infection resolved rapidly, the low-grade pyrexia ended on May 30, and her general condition steadily improved.The anaemia did not respond to oral iron, and an iron-absorption test showed no absorption.A course of "ferrivenin " totalling 1.47 g. was given, raising the haemoglobin to 82% (12.1 g.).Over the 1 11 days of continuous administration 3,710 mg. of gallamine triethiodide was administered (see Chart).At no time was an oxygen tent or artificial respirator required. SummaryA case of tetanus is described which began about two weeks after a minor injury to a thumb that had become septic.At the time of admission trismus and hypertonus were present.By the eighth day of the disease it was obvious that the increased frequency and severity of the tetanic spasms would not respond to normal sedation with barbiturates and morphine, and it was decided to try the effect of gallamine.At first this was adminis- tered intramuscularly, but three-hourly injections proved insufficient to control spasms.Hourly injections into the rubber tubing of a saline intravenous drip were found to be satisfactory, as was administration hourly into a subcutaneous hyaluronidase infusion.As the days passed it became noticeable that steadily increasing amounts of gallamine were required to prevent spasms; in view of this, the sudden termination of the tetanic spasms was quite unexpected.Morphine sulphate, i gr. (16mg.), and amylobarbitone sodium, 3 gr.(0.2 g.), were administered each evening and at other times as required.We wish to thank Drs. Sheila Watts and Pamela J. Houchin for their continuous and untiring help in the supervision and treatment of this patient.We
Nuclear perfusion scintigraphy as a gatekeeper for implantable cardioverter defibrillation implantation
Authors: Alida E. Borger van der Burg, Jeroen J. Bax, Eric Boersma, E.J. Pauwels, Marianne Bootsma, Lieselot van Erven, Ernst E. van der Wall, Martin J. Schalij
Journal: Journal of the American College of Cardiology (2003)
An appreciation of the injured knee.
Authors: J. P. England
Journal: British Journal of Sports Medicine (1980)

It is perhaps not inappropriate that this Symposium should be held at St. Luke's Hall in the University of Exeter because fourteen years ago St. Luke's College as it then was started an optional course in Sports medicine for their third year physical education students, and was one of the first Colleges in this country to do so.Since then it has been much concerned with all aspects of Sports medicine both on the purely medical side, and on the research side.In 1866 Palmar and Stevens wrote a bawdy play named 'The Crock'.
Cryptococcosis and Cushing's Syndrome
Authors: ROBERT P. FERGUSON
Journal: Annals of Internal Medicine (1977)

Brief Reports1 July 1977Cryptococcosis and Cushing's SyndromeROBERT P. FERGUSON, M.D., J. KELLY SMITH, M.D., F.A.C.P.ROBERT P. FERGUSON, M.D.Search for more papers by this author, J. KELLY SMITH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough cryptococcosis complicating steroid therapy is well described, cryptococcosis has not, to our knowledge, been reported in the English language literature since 1950 in the presence of Cushing's syndrome secondary to endogenous steroid excess. Accordingly, a case is described of fulminant cryptococcal pneumonia with dissemination and development of meningitis complicating Cushing's syndrome, probably secondary to an ectopic ACTH-producing hepatic adenocarcinoma.A 59-year-old white man presented 1 month before his present admission, with Cushing's syndrome. The morning serum cortisol level was 64 µg/dl, and the evening serum cortisol level was 80 µg/dl. The 24-h urine cortisol was 7150 µg (normal range,...References1. LITTMAN M: Cryptococcosis (torulosis). Current concepts and therapy. Am J Med 27:976-998, 1959 CrossrefMedlineGoogle Scholar2. GADEBUSCH H and GIKAS P: The effect of cortisone upon experimental pulmonary cryptococcosis. Am Rev Respir Dis 92:64-74, 1965 Google Scholar3. DIAMOND R and BENNETT J: Prognostic factors in cryptococcal meningitis. Ann Intern Med 80:176-181, 1974 LinkGoogle Scholar4. SAKOWITZ A and SAKOWITZ B: Disseminated cryptococcosis. Diagnosis by fiberoptic bronchoscopy and biopsy. JAMA 236:2429-2430, 1976 CrossrefMedlineGoogle Scholar5. PLOTZ C, KNOWLTON A, and RAGAN C: The natural history of Cushing's Syndrome. Am J Med 13:597-614, 1952 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT P. FERGUSON, M.D.; J. KELLY SMITH, M.D., F.A.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe value of reporting casesAdrenal infectionsCriptococose pulmonar pseudotumoral associada à síndrome de CushingCushing's Disease and Sphenoidal Aspergilloma. A case reportDisseminated Cryptococcosis in a Patient with Pituitary Cushing`s DiseaseFunctioning adrenal black adenoma with pulmonary and cutaneous cryptococcosis: A case report and review of English literatureCushing’s syndrome complicated by multiple opportunistic infectionsGlucocorticoids and InfectionCryptococcosisAspergillosis of the central nervous system: Clinicopathological analysis of 17 patientsOpportunistic Infections in Endogenous Cushing's SyndromeBARNEY S. GRAHAM, M.D., W. STUART TUCKER Jr., M.D.Fungal infections in the compromised host 1 July 1977Volume 87, Issue 1Page: 65-66KeywordsAdenocarcinomaCortisolCryptococcosisMeningitisPneumoniaSteroid therapyUrine ePublished: 1 December 2008 Issue Published: 1 July 1977 PDF downloadLoading ...
Tracheotomy in Acute Obliterative Laryngotracheobronchitis
Authors: J. N. Briggs, J. R. Heseltine
Journal: BMJ (1952)

Shelield 2 1 zI (38.2'C.), pulse 100, and respirations 32; there was cyano- sis, and excess mucus in the mouth with diminished air entry in the chest and slight recession.Crystalline penicillin, of upper respiratory 1 mega unit, was given immediately and pharyngo-laryngeal ;o admission.suction was carried out, using a direct-vision laryngoscope.BRITSH