Pancreatitis and Gold Treatment of Rheumatoid Arthritis
Authors: Allan D. Eisemann, Nancy J. Becker, Philip B. Miner, Jon Fleming
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 November 1989Pancreatitis and Gold Treatment of Rheumatoid ArthritisAllan D. Eisemann, MD, Nancy J. Becker, MD, Philip B. Miner Jr., MD, Jon Fleming, MDAllan D. Eisemann, MDSearch for more papers by this author, Nancy J. Becker, MDSearch for more papers by this author, Philip B. Miner Jr., MDSearch for more papers by this author, Jon Fleming, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-10-860_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Gold treatment of rheumatic diseases is frequently curtailed by treatment-limiting skin rash, mucositis, proteinuria, and diarrhea. Less frequent but more toxic side effects include gold-induced hepatitis, "gold lung," neutropenia, and peripheral neuropathy. We describe two cases of pancreatitis associated with gold treatment.A 44-year-old white woman with rheumatoid arthritis developed mild fever and upper abdominal pain associated with nausea, vomiting, fever (102.2°F) and diminished bowel sounds 5 days after her fifth injection of gold (total dose, 160 mg). By day 4, amylase peaked at 520 IU/L (normal, 5 to 90 IU/L) and lipase was greater than 90...References1. Crooke S and Snyder R. The cellular and molecular pharmacology of auranofin and related gold complexes. Scand J Rheum. 1986;63(Suppl):1-18. Google Scholar2. Mallory A and Kern F. Drug-induced pancreatitis: a critical review. Gastroenterology. 1980;78:813-20. CrossrefMedlineGoogle Scholar3. Howrie D and Gartner J. Gold-induced hepatotoxicity: case report and review of the literature. J Rheum. 1982;9:727-9. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Allan D. Eisemann, MD; Nancy J. Becker, MD; Philip B. MinerJr., MD; Jon Fleming, MDAffiliations: McFarland Clinic Ames, IA 50010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsThe Risk of Chronic Pancreatitis in Patients with Psoriasis: A Population-Based Cohort StudyIncreased Risk of Acute Pancreatitis in Patients with Rheumatoid Arthritis: A Population-Based Cohort StudyChapter 10 Gastrointestinal Manifestations of Rheumatoid ArthritisDrug-Induced Acute Pancreatitis: An Evidence-Based ReviewAn autopsy case of acute pancreatitis with a high serum IgG4 complicated by amyloidosis and rheumatoid arthritisThe Adverse Drug Reaction in the Gastrointestinal Tract: An OverviewManagement of PancreatitisReview article: Drug-induced pancreatitisThe radiology of drug-induced disorders in the gastrointestinal tractDrug-Induced PancreatitisMetals 15 November 1989Volume 111, Issue 10Page: 860-861KeywordsFeversLungsNauseaNeutropeniaPancreatitisPeripheral neuropathyProteinuriaRashesRheumatoid arthritisVomiting ePublished: 1 December 2008 Issue Published: 15 November 1989 PDF downloadLoading ...