Thrombocytopenia, Eosinophilia, and Ranitidine
Authors: U. GAFTER
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 March 1987Thrombocytopenia, Eosinophilia, and RanitidineU. GAFTER, M.D., L. KOMLOS, Ph.D., T. WEINSTEIN, M.D., D. ZEVIN, M.D., J. LEVI, M.D.U. GAFTER, M.D.Search for more papers by this author, L. KOMLOS, Ph.D.Search for more papers by this author, T. WEINSTEIN, M.D.Search for more papers by this author, D. ZEVIN, M.D.Search for more papers by this author, J. LEVI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-477_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Thrombocytopenia induced by ranitidine is rare (1-3). We describe the case of a patient who developed thrombocytopenic purpura and eosinophilia after initiation of ranitidine treatment. The thrombocytopenia could be attributed to cell-mediated hypersensitivity.A 57-year-old man with polycystic kidney disease, hypertension, and mild renal failure was followed in the outpatient nephrology clinic. His past history included diabetes mellitus for 15 years treated with an appropriate diet. For the last 10 years he had had angina pectoris, for which he underwent a three-vessel coronary bypass operation. He had also had bilateral carotid endarterectomy. His recent medications included atenolol,...References1. ZELDESFRIEDMANISSELBACHER JLK. Ranitidine: a new H2-receptor antagonist. N Engl J Med. 1983;309:1368-73. CrossrefMedlineGoogle Scholar2. MCCARTHY D. Ranitidine or Cimetidine [Editorial]. Ann Intern Med. 1983;99:551-3. LinkGoogle Scholar3. SPYCHALWICKHAM RN. Thrombocytopenia associated with ranitidine. Br Med J 1985;291:1687. CrossrefMedlineGoogle Scholar4. DACIELEWIS JS. Practical Haematology. London: Churchill Livingstone; 1970:330-1. Google Scholar5. SOBORGBENDIXEN MG. Human lymphocyte migration as a parameter of hypersensitivity. Acta Med Scand. 1967;181:247-56. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Golda Medical Center, Hasharon Hospital, Petah-Tiqva Tel-Aviv University Medical Center Tel-Aviv Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced EosinophiliaAntihistaminesAntihistaminesAn Unusual Case of Thrombocytopenia and Leukopenia Associated with Diltiazem and AcyclovirTransient, Profound Thrombocytopenia in a Premature Infant: Is this a Ranitidine-Induced Immune Reaction?Histamine-2 (H2) Receptor Antagonists May not necessarily Cross-React to Induce ThrombocytopeniaAcute Eosinophilic Pneumonia Associated with RanitidineCutaneous delayed reaction to ranitidineRanitidine and ThrombocytopeniaRanitidine-associated autoimmune hemolytic anemia in a health maintenance organization populationRPossible Severe Thrombocytopenia Associated with a Single Dose of PlicamycinCimetidine and ranitidine may not cross-react to cause thrombocytopeniaReversible Hematologic Suppression during Ranitidine TreatmentHaematological Adverse Effects of Histamine H2-Receptor AntagonistsGastrointestinal drugsClinically Important Adverse Effects and Drug Interactions with H 2 -Receptor Antagonists: An Update 1 March 1987Volume 106, Issue 3Page: 477-477KeywordsCarotid endarterectomyDiabetes mellitusDietEosinophiliaHypersensitivityHypertensionNephrologyOutpatient clinicsPolycystic kidney diseaseRenal failure Issue Published: 1 March 1987 PDF downloadLoading ...