tbuckley/cabot-search huggingface dataset:
FURTHER NOTES ON PROTOZOAN INFECTIONS OCCURRING AT THE KING GEORGE HOSPITAL
Authors: H. M. Woodcock, W. J. Penfold
Journal: BMJ (1916)

travel.To be once again in their home-country and within reach of friends does much to help recovery in bad cases.Similarly, the bright surroundings of our hospitals are valuable therapeutic agents, and they ought to be aided by a cheery optimism wlhich I think it will not be difficult for any of you to cultivate.Always remember that one of the most valuable and cheapest remedies we possess is hope.
Primary Ventricular Fibrillation Is Associated With Increased Paced Right Ventricular Electrogram Fractionation
Authors: R.C. Saumarez, S. Heald, J. Gill, A.K.B. Slade, M. de Belder, F. Walczak, E. Rowland, D.E. Ward, A.J. Camm
Journal: Circulation (1995)

Background The mechanisms of spontaneous ventricular fibrillation (primary VF) in patients without structural heart disease are obscure. A new technique has shown that in patients with hypertrophic cardiomyopathy conduction of fractionated ventricular paced beats, recorded at several right ventricular sites, is prolonged in individuals who have suffered a VF arrest, and this may reveal one component of a reentrant substrate. Patients with primary VF were studied with the same methods to determine whether similar abnormalities are present in this group. Methods and Results Nine patients with primary VF were studied by pacing one right ventricular (RV) site by use of a constant drive train with an extrastimulus inserted every third beat and reducing the extrastimulus coupling interval (S1S2 interval) by 1 ms on each occasion while recording at three other sites. The delay of each fractionated potential in the high-pass–filtered electrograms in response to the extrastimulus was determined and used to form conduction curves of delay versus the S1S2 interval. These curves were repeated by pacing each RV site in turn and recording from the other three sites. The curves were characterized by determining the S1S2 interval at which electrogram components increased in delay by 0.75 ms/20 ms reduction in S1S2 interval and the increase in electrogram duration between a coupling interval of 350 ms and 1 ms above refractoriness. Seven control patients were studied using the same method. The mean increase in electrogram duration in VF patients was 13 ms (range, 3 to 23 ms) compared with 4 ms (range, −2 to 14 ms) in unaffected control patients. The extrastimulus coupling interval at which delay increased was 318 ms (range, 293 to 334 ms) in VF patients and 274 ms (range, 265 to 284 ms) in control patients ( P &lt;.01). There was no difference between the number of fractionated potentials in VF patients and control patients. Conclusions In primary VF patients, the individual potentials within fractionated electrograms have increased delays when compared with control patients. This may identify one component of a reentrant arrhythmic substrate.
Usefulness of the QuantiFERON<sup>®</sup>test in the confirmation of latent tuberculosis in association with erythema induratum
Authors: J. Angus, C. Roberts, K. Kulkarni, I. Leach, R. Murphy
Journal: British Journal of Dermatology (2007)

Journal Article Usefulness of the QuantiFERON® test in the confirmation of latent tuberculosis in association with erythema induratum Get access J. Angus, J. Angus Departments of Dermatology and Histopathology, Queen's Medical Centre, Nottingham NG7 2UH, U.K. E‐mail: janeteangus@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar C. Roberts, C. Roberts Departments of Dermatology and Histopathology, Queen's Medical Centre, Nottingham NG7 2UH, U.K. E‐mail: janeteangus@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar K. Kulkarni, K. Kulkarni Departments of Dermatology and Histopathology, Queen's Medical Centre, Nottingham NG7 2UH, U.K. E‐mail: janeteangus@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar I. Leach, I. Leach Departments of Dermatology and Histopathology, Queen's Medical Centre, Nottingham NG7 2UH, U.K. E‐mail: janeteangus@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar R. Murphy R. Murphy Departments of Dermatology and Histopathology, Queen's Medical Centre, Nottingham NG7 2UH, U.K. E‐mail: janeteangus@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 6, 1 December 2007, Pages 1293–1294, https://doi.org/10.1111/j.1365-2133.2007.08227.x Published: 01 December 2007
FRI0561 The role of patient global disease activity score in the definition of acr/eular remission in very early ra - results from the nor-veac study
Authors: M. D. Mjaavatten, A. J. Haugen, H. N. Nygaard, O. Bjørneboe, H. C. Gulseth, T. K. Kvien
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Failure to fulfill the patient global disease activity (PGA) score &lt; 1 cm criterion in the 2010 ACR/EULAR remission criteria has been shown to be the major determinant of "near misses" of remission in established RA<sup>1</sup>. It is not known if this factor is of the same importance when RA patients are identified and treated at a very early stage. <h3>Objectives</h3> To investigate the fulfillment of the Boolean version of the 2010 ACR/EULAR remission criteria after 2 years in patients with RA in a very early arthritis clinic, and to determine the major reasons for failing to fulfill these criteria. <h3>Methods</h3> Patients with arthritis of &lt;16 weeks' duration were included in an early arthritis cohort from 2004-2010 and followed for 2 years with a comprehensive data collection. Patients were treated according to current clinical practice and not with a structured treat-to-target approach. Patients with RA according to the 2010 classification criteria with 2 years follow-up time were included in the present analysis. Frequency of 2-year remission was calculated, as well as which criterion was not fulfilled in patients fulfilling 3 Boolean criteria. <h3>Results</h3> Of 1086 very early arthritis patients included, 185 (17.0 %) had RA according to the 2010 criteria at inclusion and had 2-year data on ACR/EULAR Boolean remission (mean (SD) age 52.5 (13.8) years, n (%) females 112 (60.5), median (25-75 percentile) duration of symptoms at inclusion 63 (40-83) days). After 2 years, 41/185 (22.2 %) were in Boolean remission, while 70/176 (39.8 %) were in SDAI remission (SDAI ≤3.3). 63 patients (34.5 %) fulfilled 3 of the Boolean criteria (criterion not fulfilled: PGA n=52, CRP n=5, TJC n=3, SJC n=1, missing data n=2) Omitting the PGA criterion, the remission rate was 93/185 (50.3 %). 44/52 (84.6 %) of patients with PGA &gt; 1 had evaluator's global disease activity (EGA) ≤ 1; 25 of these 44 (56.8 %) were in SDAI remission. 13 patients who were not in ACR/EULAR Boolean remission fulfilled the PGA criterion. <h3>Conclusions</h3> Elevated PGA was the major reason for not being in remission after 2 years in patients with very early RA fulfilling 3 out of 4 of the Boolean remission criteria, and in the majority of these patients EGA was ≤ 1. Application of an index-based remission definition (SDAI) resulted in higher remission frequencies in patients with elevated PGA. <h3>References</h3> Studenic P, et al. Near misses for ACR/EULAR criteria for remission: effects of patient global assessment in Boolean and index-based definitions. Ann Rheum Dis 2012;71:1702-5. <h3>Disclosure of Interest</h3> None Declared
A Case Study of United Healthcare: Lessons for Health Care Plans
Authors: David J. Jones
Journal: JAMA (1986)

This is, as the title states, a study. It warrants that description because it is well researched and well documented and its results are competently analyzed. Its subtitle, Lessons for Health Care Plans, is overly modest in targeting its readers, as the lessons can be of value to a broader audience. Any organization—insurance company, hospital corporation, or medical group, for example—considering entry into the alternative health care business or doing business with a health maintenance or preferred provider organization could benefit from this work. And, students of administration, whether in business generally or health care specifically, will find this a useful adjunct to their management texts.  In seven chapters, the three authors convey the life of this innovative enterprise from its inception as an idea in July 1972 through its eight operational years, until it ceased doing business in August 1982. The detailed chronology of that experience in the appendixes
PD3-3-7: Safety and Pharmacokinetics (PK) of AMG 706 With Carboplatin/Paclitaxel (C/P) and/or Panitumumab for the treatment of patients with advanced non-small cell lung cancer (NSCLC)
Authors: George R. Blumenschein, Alan Sandler, Timothy O’Rourke, Jesse McGreivy, Yu-Nien Sun, Yining Ye, Mandy Parson, Joe J. Stephenson
Journal: Journal of Thoracic Oncology (2007)
Abstract A2: Circulating epithelial tumor cells (CETC) for molecular analysis, chemo sensitivity testing <i>in vitro</i> and therapy monitoring <i>in vivo</i>
Authors: Katharina Pachmann, Torsten Kroll, Stephanie Carl, Ulrich Pachmann
Journal: Clinical Cancer Research (2010)

Abstract Most breast cancer patients do not die of their primary tumor but from metastases developing sometimes years after the primary tumor has been removed. The first spread of tumor cells detectable with conventional methods is in the lymph nodes and patients with lymph node positive disease have a poorer disease free survival than patients without affected lymph nodes. Cells from the tumor seem also to be disseminated continuously into blood during tumor growth and an increase in circulating epithelial tumor cell (CETC) numbers during adjuvant therapy is correlated with an 11- 16 fold increase in hazard of relapse. A reincrease in numbers indicates increasing resistance to the applied drugs. Therefore, it would be desirable to better characterize these cells, test them for alternative drugs and monitor the actual response to the therapy decided on. For this purpose we have developed a method to isolate individual CETC from blood from breast cancer patients and to successfully perform molecular characterization. Cells from the same sample were subject to chemo sensitivity testing and the drugs with the highest effectivity defined. Patients were subsequently treated according to guide lines. The molecular characteristics, sensitivity to the applied drugs and response of the CETC to these drugs were subsequently compared to clinical outcome. The response of CETC to therapy correlated highly with the previously tested chemo sensitivity and with the reduction of an index metastasis in metastatic breast cancer patients and progression free survival. The molecular characteristics of these cells are under investigation. Citation Information: Clin Cancer Res 2010;16(7 Suppl):A2
MODERN METHODS AND RESULTS OF TREATING MALIGNANCY OF THE BLADDER
Authors: HERMON C. BUMPUS
Journal: JAMA (1924)

A perusal of the literature or of statistics relative to malignancy of the bladder inevitably leaves the reviewer with three major impressions: (1) the lack of a uniformity in the classification of tumors of the bladder; (2) the variety of methods employed in their treatment, and (3) the depressingly poor results obtained. Improvement in classification is essential before the value of any method of treatment can be determined. It is obvious that no deductions of value are possible so long as various investigators report their cases under entirely different classifications. Not until a uniform nomenclature has been adopted can the best type of treatment be selected and the final results from such treatment improve. The present confusion with regard to classification is best appreciated after a review of some of the recent reports on malignancy of the bladder. Kidd<sup>1</sup>refers to simple papillomas, inflammatory papillomas, true papillomas, simple primary
Two Occult Primaries Discovered on PET/CT in a Patient With Paraparesis
Authors: Shrikant Solav, Dhanpathi Halnaik
Journal: Clinical Nuclear Medicine (2010)

Metastasis with an occult primary is a challenging issue. Subjecting these patients to a host of tests ranging from sonography, regional computed tomography (CT), whole-body CT scan, magnetic resonance imaging, tumor markers, etc could be agonizing to the patient and the family. FDG PET is a potential tool that could provide objective evidence in some of these cases to settle the issue. An unknown (occult) primary is conventionally defined as a neck mass that is histologically proven to be malignant in the absence of previous malignancy with no demonstrable primary tumor by conventional investigative means. However, metastasis of an occult primary may also present with lesions outside the neck such as the brain, skeleton, liver, etc. PET/CT has been reported to have a sensitivity between 26% and 43% to localize an occult primary. This case demonstrates an unusual occurrence of 2 occult primary sites in a patient presenting with skeletal manifestations. One occult primary was found to be in the nasopharynx and other was found to be in the prostate gland. Please note that the value of FDG in tumors of the head and neck is undisputed, and although FDG PET has variable uptake in a prostatic neoplasm, here is an exceptional case in which a focal eccentric uptake in the prostate gland was subsequently proven to be neoplastic.
Medical image segmentation on GPUs – A comprehensive review
Authors: Erik Smistad, Thomas L. Falch, Mohammadmehdi Bozorgi, Anne C. Elster, Frank Lindseth
Journal: Medical Image Analysis (2014)

Segmentation of anatomical structures, from modalities like computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound, is a key enabling technology for medical applications such as diagnostics, planning and guidance. More efficient implementations are necessary, as most segmentation methods are computationally expensive, and the amount of medical imaging data is growing. The increased programmability of graphic processing units (GPUs) in recent years have enabled their use in several areas. GPUs can solve large data parallel problems at a higher speed than the traditional CPU, while being more affordable and energy efficient than distributed systems. Furthermore, using a GPU enables concurrent visualization and interactive segmentation, where the user can help the algorithm to achieve a satisfactory result. This review investigates the use of GPUs to accelerate medical image segmentation methods. A set of criteria for efficient use of GPUs are defined and each segmentation method is rated accordingly. In addition, references to relevant GPU implementations and insight into GPU optimization are provided and discussed. The review concludes that most segmentation methods may benefit from GPU processing due to the methods' data parallel structure and high thread count. However, factors such as synchronization, branch divergence and memory usage can limit the speedup.
ADAMANTINOMA OF THE TIBIA
Authors: Hamilton B. G. Robinson
Journal: JAMA (1942)

<h3>To the Editor:—</h3> Drs. Malcolm B. Dockerty and Henry W. Meyerding have presented a valuable study of adamantinoma of the tibia inThe Journal(July 18, p. 932). I have been greatly interested in these apparent enamel organ tumors of the tibia and have had the opportunity of studying sections from the tumor reported by Bishop (<i>South. M. J.</i><b>30</b>:571 [June] 1937). They appear to ape the enamel organ tumor but never seem as well differentiated as those occurring in the jaws. It is possible that those in the tibia are merely squamous cell carcinomas resembling the enamel organ tissues by some odd coincidence. It is even possible that the publication of Fischer's case in 1913 attracted attention to this oddity and led to the reports on the 16 subsequent cases between 1930 and 1941. Why should an enamel organ neoplasm select the tibia as its only site remote
New Method Detects Genetic Defects in Egg Cells
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
simple Solution to Problem of Biostator-Induced Insulin Aggregation
Authors: M D Harris, M B Davidson, C S Rosenberg
Journal: Diabetes Care (1986)

It has recently been reported that there is a significant loss of insulin immunoreactivity and bioavailability secondary to heat-induced insulin aggregation during prolonged insulin delivery by the Biostator. This artifact of Biostator insulin delivery system makes data generated by studies that use prolonged, continuous insulin infusions performed with the Biostator uninterpretable. We report the prevention of this problem by the addition of 20 ml heparinized whole blood to a 500-ml reservoir containing the insulin to be infused. The proposed solution is simple, economical, and without risk to the subject since his or her own blood can be used.
Fingerprinting Acute Leukemia: DNA Methylation Profiling of B-Acute Lymphoblastic Leukemia
Authors: Luisa Cimmino, Iannis Aifantis
Journal: Cancer Discovery (2012)

Abstract Summary: In this issue of Cancer Discovery, Geng and colleagues report on their use of a combination of promoter cytosine methylation profiling with gene expression and ChIP sequencing to elucidate molecular signatures of adult B-acute lymphoblastic leukemia patient samples with BCR–ABL1, E2A–PBX1, and MLL rearrangements. The unique epigenetic and gene expression signatures of these clinically unfavorable B-ALL subtypes identify novel biomarkers and provide a strong rationale for repurposing existing therapies to treat these molecularly distinct diseases. Cancer Discov; 2(11); 976–8. ©2012 AACR. Commentary on Geng et al., p. 1004.
Points from Letters: Scotland's Anaesthetists
Authors: C. S. Jones
Journal: BMJ (1971)

dialysate,l is recommended routinely for all chronically dialysed patients.It is suggested that the patient under this treatment can not only substitute iron, folate, and amino-acid losses from the remaining blood into the dialyser, blood sampling for analysis, and to the dialysate, but also effectively utilize these elements incorporated in the diet, according to his real needs.-Weare, etc.,
13-cis-Retinoic acid therapy induces insulin resistance, regulates inflammatory parameters, and paradoxically increases serum adiponectin concentration
Authors: Maikki K. Heliövaara, Anita Remitz, Sakari Reitamo, Anna-Maija Teppo, Sirkka-Liisa Karonen, Pertti Ebeling
Journal: Metabolism (2007)
Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway
Authors: Bertrand Gondouin, Claire Cerini, Laetitia Dou, Marion Sallée, Ariane Duval-Sabatier, Anneleen Pletinck, Raymond Calaf, Romaric Lacroix, Noémie Jourde-Chiche, Stéphane Poitevin, Laurent Arnaud, Raymond Vanholder, Philippe Brunet, Françoise Dignat-George, Stéphane Burtey
Journal: Kidney International (2013)
Use of alpha-tocopherylquinone in the treatment of ulcerative colitis.
Authors: J D Bennet
Journal: Gut (1986)

The effect of alpha-tocopherylquinone (alpha-TQ) and a low fat diet on a patient with chronic continuous ulcerative colitis was described. The patient9s condition improved dramatically with both colonic and extraintestinal manifestations of the disease greatly reduced with doses of alpha-TQ of 3.0 g/day (50 mg/kg/d) or greater. Withdrawal of alpha-TQ for periods of one to two days produced recurrence of inflammation which was again reduced upon re-introduction of alpha-TQ.
The effect of ultra-nanocrystalline diamond films on the proliferation and differentiation of neural stem cells
Authors: Ying-Chieh Chen, Don-Ching Lee, Chao-Yang Hsiao, Yu-Fen Chung, Huang-Chin Chen, Joseph P. Thomas, Way-Faung Pong, Nyan-Hwa Tai, I.-Nan Lin, Ing-Ming Chiu
Journal: Biomaterials (2009)
Notes on techniques referred to in Proceedings
Authors: M. S. Moss
Journal: British Journal of Sports Medicine (1976)

A generic name for a series of separation techniques used in analytical chemistry.Discovered by the Russian botanist, Michael Twsett in 1903, it was used initially in the separation of plant pigments, hence the name, but has since been extended to applications in most areas of organic and inorganic chemistry.The extension of this elegant and ingenious technique forms one of the most fascinating studies in the history of science.
Nutrition and Wound Healing
Authors: Judy A. Driskell
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radioimmune analysis of an unexpected mouse allotype.
Authors: C L DeWitt, M J Bosma
Journal: The Journal of Experimental Medicine (1979)

We have used a radioimmune assay to confirm our earlier findings of an unexpected immunoglobulin allotype in Igb-congenic BALB/c mice. Although these mice were bred to exclude the IgG2a allotype of BALB/c (Ig-la), an Ig-la-like antigen was detected in the 7S Ig fraction of two (of five) pooled serum samples, it represented 0.1--0.3% of the total 7S protein and was indistinguishable from a reference Ig-la. The detection of putative Ig-la in Igb-congenic mice is inconsistent with the notion that allotypes are products of allelic structural genes. It appears rather that expression of Ig-la is controlled by allelic regulator genes and that its low and transient production in Igb-congenic mice results from incomplete negative regulation.