tbuckley/cabot-search huggingface dataset:
Surgery of the Chest
Authors: Paul C. Adkins
Journal: JAMA (1969)

Drs. Gibbon, Sabiston, and Spencer, with the collaboration of 48 outstanding authorities, have succeeded admirably in producing the most complete and definitive work to date in the field of thoracic and cardiac surgery. Compared to the first edition of this text published 6 1/2 years ago, the changes and additions reflect the trend in the entire field with more emphasis on cardiorespiratory physiology and on cardiac surgery. Of the 42 chapters in the current edition, 15 have been retained and updated by their original authors. These are primarily in the area of pulmonary and esophageal surgery, the chest wall, and general patient care. The chapter on special diagnostic procedures in cardiac surgery has been expanded to include the latest techniques.  Twenty-seven chapters of this book are either entirely new or have been written by new authors. Chapters on cardiorespiratory dynamics, extracorporeal circulation, and hypothermia are all outstanding for their comprehensive
Reply from Authors re: Jihad H. Kaouk and Riccardo Autorino. Laparoendoscopic Single-site Surgery (LESS) and Nephrectomy: Current Evidence and Future Perspectives. Eur Urol 2012;62:613–5
Authors: Xinxiang Fan, Tianxin Lin, Kewei Xu, Jian Huang
Journal: European Urology (2012)
Recoverin Improves Rod-Mediated Vision by Enhancing Signal Transmission in the Mouse Retina
Authors: Alapakkam P. Sampath, Katherine J. Strissel, Rajesh Elias, Vadim Y. Arshavsky, James F. McGinnis, Jeannie Chen, Satoru Kawamura, Fred Rieke, James B. Hurley
Journal: Neuron (2005)
Public, Private Insurers Refusing to Pay Hospitals for Costs of Avoidable Errors
Authors: Mike Mitka
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peer review: Peerless review
Authors: R H S Carpenter
Journal: Journal of the Royal Society of Medicine (2006)

The editorial 'Too little quality; too many doctors' (June 2006 JRSM 1 ) is incorrect to suggest that the General Medical Council (GMC) had a 'sudden demand for overseas graduates to have a work permit'.The GMC does not have any visa requirements for international medical graduates (IMGs).The Home Office is responsible for setting visa requirements.International medical graduates are responsible for ensuring that they have the appropriate visa when they enter the UK.
TRUE AND FALSE PRESYSTOLIC THRILLS
Authors: Morris H. Kahn
Journal: JAMA (1924)

In 1919, I<sup>1</sup>had the opportunity to observe a differential diagnostic point between the thrill in organic mitral stenosis and that which occurs in nonorganic heart conditions of the neurocirculatory type. I have since been able to confirm my statements at that time. The thrill in neurocirculatory asthenia, as also in some cases of thyrotoxic heart, is due to the diffusion of the apex beat as it strikes over several rib spaces with a forcible or jerky movement. This systolic shock gives to the palpating hand the impression of a presystolic thrill. The thrill is recognized as a rumble characteristically when the chest-piece of the stethoscope covers a whole interspace, being applied over two ribs. If now the stethoscope is placed obliquely on the chest wall so that its edge lies within an interspace and its mouth inclines toward either the upper or the lower rib, the rumble disappears,
Welsh agency for specialist healthcare services should be wound up, report says
Authors: Roger Dobson
Journal: BMJ (2008)

Health Commission Wales, the body set up five years ago to commission specialist services, should be wound up and replaced, a new report says.

Fundamental flaws in the way the commission was established, poor governance arrangements, and an unsound budget allocation are among the criticisms in the independent report commissioned by the Welsh Assembly’s health minister, Edwina Hart.

The report, by Mansel Aylward, chairman of the Wales Centre for Health, says that the structure, governance, and functioning of Health Commission Wales were not fit for what the organisation required.

The report also urges the setting up of an all Wales independent panel, including lay members, which will hear appeals in relation to individual commissioning decisions. This recommendation has already been accepted.

Health Commission Wales was established as an executive agency …
Bacterial culture of perfusion blood after open-heart surgery.
Authors: R Freeman, N Hjersing
Journal: Thorax (1980)

The results of routine culture of 595 consecutive specimens of perfusion blood are presented. Ten per cent of the specimens yielded bacteria overall, but it was found that the isolation rate was increased to 17.7% when the prophylactic antibodies being given during the bypass were specifically neutralised. Coagulase-negative staphylococci and diphtheroids formed the majority of organisms isolated, but Gram negative bacilli or "coliform" type were also occasionally found. A comparison of the relative findings in patients receiving prophylactic flucloxacillin or cephradine showed that the isolation rates of coagulase-negative staphylococci and diphtheroids were lower in the group receiving flucloxacillin. The origin of the bacteria isolated from perfusion blood remains uncertain but speciation of coagulase-negative staphylococci from perfusion blood and similar organisms isolated subsequently from catheter tips in the same patients revealed no evidence that the two sources of organisms were linked. Although organisms are easily and commonly found in perfusion blood, the relevance of this phenomenon to post-operative endocarditis is not clear.
Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
Authors: Mazen A. Kheirbek, Liam J. Drew, Nesha S. Burghardt, Daniel O. Costantini, Lindsay Tannenholz, Susanne E. Ahmari, Hongkui Zeng, André A. Fenton, René Hen
Journal: Neuron (2013)
Behavioral Therapy for Urinary Incontinence-Reply
Authors: Teh-wei Hu
Journal: JAMA (1989)

<h3>In Reply. —</h3> The nursing research assistants employed in follow-up did not know the patients' assignments (treatment or control) to avoid potential datacollection bias. There are several possible explanations for the durability of the training effect. First, the study may have had a carryover effect on the homes' regular nursing aides, who may have been more responsive even during follow-up because a research study was being conducted. Second, encouraging patients to hold their urine (a study objective) may have helped physiologically to reduce incontinence, especially among the 34% more cognitively alert treatment participants (Mini-Mental State Examination score, &gt;17). Last, the reinstatement of hourly checking during follow-up may have created a "checking effect" that reminded patients they needed to toilet. However, any checking effect should have affected both the experimental and the control groups. Since the experimental group consistently improved more than the control group, we are inclined to give more
Chemical Agents Affecting Experimental Caries
Authors: Isadore Zipkin
Journal: JAMA (1961)

A NUMBER of discrete chemical agents influence incidence and severity of experimental caries in the rat and hamster. Some of these agents have been clinically tested in the human being. Various fluorides, sodium lauroyl sarcosinate (SLS), lysine, various phosphates, penicillin, and tetracycline reduce caries-activity in experimental animals. Ethylene-diamine tetra-acetic acid (EDTA) and dehydroacetic acid (DHA) potentiate caries activity. In general, trace elements and vitamins do not play any significant role. <h3>Caries Inhibiting Agents</h3><h3>Fluoride.—</h3> Sodium fluoride,<sup>1</sup>sodium silico fluoride, sodium phosphorofluoridate,<sup>1</sup>ammonium silicofluoride,<sup>2</sup>and stannous fluoride<sup>3</sup>reduced animal caries-activity when administered posteruptively. Potassium hexafluorophosphate and sodium trifluoroacetate were ineffective when given in the drinking water,<sup>1</sup>and sodium fluoride, sodium silicofluoride, sodium phosphorofluoridate, and potassium hexafluorophosphate were ineffective when injected intraperitoneally. Sodium fluoride, sodium silicofluoride, sodium phosphorofluoridate—all equally cariostatic in the rat—were absorbed from the gastrointestinal tract at the same rate.<sup>4</sup>Stannous fluoride similarly
Noninvasive LV Pressure Estimation Using Subharmonic Emissions From Microbubbles
Authors: Jaydev K. Dave, Valgerdur G. Halldorsdottir, John R. Eisenbrey, Joel S. Raichlen, Ji-Bin Liu, Maureen E. McDonald, Kris Dickie, Shumin Wang, Corina Leung, Flemming Forsberg
Journal: JACC. Cardiovascular imaging (2012)
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
Authors: Danielle T. Avery, Susan L. Kalled, Julia I. Ellyard, Christine Ambrose, Sarah A. Bixler, Marilyn Thien, Robert Brink, Fabienne Mackay, Philip D. Hodgkin, Stuart G. Tangye
Journal: Journal of Clinical Investigation (2003)

The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells. This process must be strictly regulated to ensure sufficient humoral immunity while avoiding production of pathogenic autoantibodies. BAFF, a member of the TNF family, is a key regulator of B cell homeostasis. BAFF exerts its effect by binding to three receptors - transmembrane activator of and CAML interactor (TACI), B cell maturation antigen (BCMA), and BAFF receptor (BAFF-R). To elucidate the contribution of BAFF to the differentiation of B cells into ISCs, we tracked the fate of human memory B cells stimulated with BAFF or CD40L. BAFF and CD40L significantly increased the overall number of surviving B cells. This was achieved via distinct mechanisms. CD40L induced proliferation of nondifferentiated blasts, while BAFF prevented apoptosis of ISCs without enhancing proliferation. The altered responsiveness of activated memory B cells to CD40L and BAFF correlated with changes in surface phenotype such that expression of CD40 and BAFF-R were reduced on ISCs while BCMA was induced. These results suggest BAFF may enhance humoral immunity in vivo by promoting survival of ISCs via a BCMA-dependent mechanism. These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases.
Lack of Refinement in the American Medical Association.
Authors: J. F. Jenkins
Journal: JAMA (1884)

A resident of Washington writes to the New York<i>Medical Journal</i>as follows: "The usual disgraceful performances took place at the receptions. Mrs. L—generously opened her beautiful house, and provided as fine a table as Demenet could serve. She was rewarded by having men stalk in (hats on their heads) from the front room to the dining-room, where they fought like wolves for places at the tables, overturning piles of plates, breaking her expensive ornaments, and soiling her rugs with pools of tobacco-juice." The author of this slander will, in all probability, never be known, excepting to the editor of the New York<i>Medical Journal</i>, who appears to have given it circulation without attaching the name of its puerile Washington correspondent. I have the facts in my possession from the highest authority on this question that: "<i>The guests were most courteous and civil</i>." Tecumseh, Mich., July 28, 1884.
Cost–Utility Analysis
Authors: Peter J. Neumann, Richard H. Chapman, Patricia W. Stone
Journal: Annals of Internal Medicine (2001)

Letters3 April 2001Cost–Utility AnalysisPeter J. Neumann, ScD, Richard H. Chapman, SM, and Patricia W. Stone, PhD, MPH, RNPeter J. Neumann, ScDHarvard School of Public Health; Boston, MA 02115 (Neumann, Chapman)University of Rochester; Rochester, NY 14642 (Stone)Search for more papers by this author, Richard H. Chapman, SMHarvard School of Public Health; Boston, MA 02115 (Neumann, Chapman)University of Rochester; Rochester, NY 14642 (Stone)Search for more papers by this author, and Patricia W. Stone, PhD, MPH, RNHarvard School of Public Health; Boston, MA 02115 (Neumann, Chapman)University of Rochester; Rochester, NY 14642 (Stone)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-7-200104030-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Brown and colleagues' remarks about the importance of recognizing the diversity of practices used in published cost–utility analyses. We agree that research has supported the reliability and usefulness of the time-tradeoff method. It was not our intention to criticize the time-tradeoff approach or to equate it with the rating scale, which has not demonstrated such reliability (1). The sentence to which the authors refer, and which appears in the glossary accompanying our paper, simply points out that the time-tradeoff approach does not incorporate uncertainty and thus does not technically produce a “utility.”The purpose of our ...Reference1. Torrance GW. Measurement of health state utilities for economic appraisal. J Health Econ. 1986;5:1-30. [PMID: 0010311607] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Harvard School of Public Health; Boston, MA 02115 (Neumann, Chapman)University of Rochester; Rochester, NY 14642 (Stone) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Quality of Reporting in Published Cost-Utility Analyses, 1976–1997 Peter J. Neumann , Patricia W. Stone , Richard H. Chapman , Eileen A. Sandberg , and Chaim M. Bell Cost–Utility Analysis Gary C. Brown , Melissa M. Brown , and Sanjay Sharma Metrics 3 April 2001Volume 134, Issue 7Page: 626 ePublished: 3 April 2001 Issue Published: 3 April 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Alternative testing systems for evaluating noncarcinogenic, hematologic toxicity.
Authors: R E Parchment
Journal: Environmental Health Perspectives (1998)

Hematopoietic tissues are the targets of numerous xenobiotics. Clinical hematotoxicity is either a decrease or an increase in peripheral blood cell counts in one or more cell lineages--a cytopenia or a cytosis, respectively--that carries a risk of an adverse clinical event. The purpose of in vitro hematotoxicology is the prediction of these adverse hematologic effects from the effects of the toxicants on human hematopoietic targets under controlled experimental conditions in the laboratory. Building on its important foundations in experimental hematology and the wealth of hematotoxicology data found in experimental oncology, this field of alternative toxicology has developed rapidly during the past decade. Although the colony-forming unit-granulocyte/monocyte neutrophil progenitor is most frequently evaluated, other defined progenitors and stem cells as well as cell types found in the marrow stroma can be evaluated in vitro. End points have been proposed for predicting toxicant exposure levels at the maximum tolerated dose and the no observable adverse effect level for the neutrophil lineage, and several clinical prediction models for neutropenia have developed to the point that they are ready for prospective evaluation and validation in both preclinical species and humans. Known predictive end points are the key to successful comparisons across species or across chemical structures when in vitro dose-response curves are nonparallel. Analytical chemistry support is critical for accurate interpretation of in vitro data and for relating the in vitro pharmacodynamics to the in vivo pharmacokinetics. In contrast to acute neutropenia, anemia and acute thrombocytopenia, as well as adverse effects from chronic toxicant exposure, are much more difficult to predict from in vitro data. Pharmacologic principles critical for clinical predictions from in vitro data very likely will apply to toxicities to other proliferative tissues, such as mucositis.
Abstract IA27: Combinatorial immunotherapy using whole tumor antigen: Evidence from phase I trials
Authors: Lana E. Kandalaft, Janos Tanyi, Cheryl Chiang, George Coukos
Journal: Clinical Cancer Research (2013)

Abstract Novel therapeutic strategies are warranted in recurrent ovarian cancer. We report two independent consecutive studies of combinatorial immunotherapy comprising dendritic cell (DC)-based autologous whole tumor antigen vaccination in combination with antiangiogenesis therapy. Thirty one patients with recurrent progressive stage III and IV ovarian cancer with available tumor lysate from debulking surgery enrolled in two different vaccination studies. First six underwent priming with intravenous bevacizumab and oral metronomic cyclophosphamide followed by vaccination with an autologous DC preparation pulsed with freeze-thaw autologous tumor lysate while the other 25 underwent vaccination with an enhanced vaccine of autologous DCs loaded with HOCl-oxidized autologous tumor lysate administered intranodally in combination with antiangiogenesis therapy. Both studies were followed by lymphodepletion and transfer of autologous vaccine-primed, ex vivo CD3/CD28-costimulated peripheral blood T-cells, in combination with antiangiogenesis therapy and vaccination. Feasibility, safety, biological and clinical efficacy were evaluated. Eleven patients have completed vaccination and T cell transfer to date, while twenty-three additional patients completed vaccination only. Vaccination was well tolerated and elicited tumor-specific T cell responses against various ovarian tumor antigens. Preliminary results demonstrate that patients' DCs loaded with HOCl-oxidized lysate elicited strong tumor-specific IFN-gamma; secretions and produced high levels of Th1-priming cytokines and chemokines, including IL-12. A clinical benefit of 65% correlated with the immune response with some patients experiencing prolonged progression free survival. Following lymphodepletion, adoptive transfer of vaccine-primed T-cells was well tolerated and resulted in durable reduction of T-regulatory cells and restoration of vaccine-induced antitumor immunity in patients who experienced clinical benefit. One patient exhibited a complete response at end of study and stable disease was observed in 7 out of the 11 patients who completed vaccination and T cell transfer. Data on additional patients will be presented at the meeting. Our results suggest the use of combinatorial cellular immunotherapy comprising DC vaccination with whole tumor antigen and adoptive lymphocyte transfer using tumor antigen-specific T cells for the treatment of patients with recurrent ovarian cancer is promising yet warrants further investigation. Citation Format: Lana E. Kandalaft, Janos Tanyi, Cheryl Chiang, George Coukos. Combinatorial immunotherapy using whole tumor antigen: Evidence from phase I trials. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr IA27.
Osteopontin Expression Is Increased in the Heritable Cardiomyopathy of Syrian Hamsters
Authors: Errol B. Williams, Igor Halpert, Samuel Wickline, Glenn Davison, William C. Parks, Jeffrey N. Rottman
Journal: Circulation (1995)

Background Osteopontin, a noncollagenous matrix protein, is transiently expressed in the heart after experimental cardiac injury, but its expression in states of continuing cardiac remodeling is unknown. We evaluated osteopontin expression in the heritable cardiomyopathy of the Syrian hamster. Methods and Results Hamster hearts were obtained for RNA isolation and analysis and in situ hybridization from two groups: normal control animals (n=4) and untreated cardiomyopathic hamsters (n=5). Osteopontin mRNA was 12-fold greater in cardiomyopathic hearts compared with normal controls (1.76±0.31 versus 0.14±0.04 arbitrary units normalized to GAPDH, mean±SEM, P &lt;.05). In situ hybridization was used to define the origin of osteopontin in the heart. Osteopontin mRNA above background levels was not detected in sections from noncardiomyopathic hamster hearts but was readily detected in sections from cardiomyopathic hamsters, in which it originated in cells morphologically consistent with tissue macrophages. Conclusions In the hamster, osteopontin is expressed in heritably cardiomyopathic hearts under conditions of chronic injury and repair, and the source of osteopontin message appears to be tissue macrophage-like cells in foci of inflammation. This model could be used to evaluate the biological role of osteopontin in myocardial inflammation and remodeling.
Lung Cancer: Scalpels, Beams, Drugs, and Probes
Authors: John D. Minna, Daniel C. Ihde, Eli J. Glatstein
Journal: New England Journal of Medicine (1986)

Ninety percent of the 149,000 people who will have lung cancer in the United States this year will die of their disease,1 and the physicians caring for them must decide the best way to confront a bleak situation. The article by the Lung Cancer Study Group in this issue of the Journal 2 shows the limitations of two components (surgery and radiotherapy) of our triad of weapons in the treatment of lung cancer. In this prospective randomized clinical trial, postoperative adjuvant chest irradiation was given to patients with resected epidermoid (squamous-cell) carcinoma and positive hilar (N1) or mediastinal (N2) nodes in . . .
Blood glucose level and outcome after cardiac arrest: insights from a large registry in the hypothermia era
Authors: Fabrice Daviaud, Florence Dumas, Nadège Demars, Guillaume Geri, Adrien Bouglé, Tristan Morichau-Beauchant, Yên-Lan Nguyen, Wulfran Bougouin, Frédéric Pène, Julien Charpentier, Alain Cariou
Journal: Intensive Care Medicine (2014)