Missed Opportunities in the Trial on Proton-Pump Inhibitor Therapy in Bleeding Peptic Ulcers
Authors: Vivian Yih
Journal: Annals of Internal Medicine (2009)

Letters20 October 2009Missed Opportunities in the Trial on Proton-Pump Inhibitor Therapy in Bleeding Peptic UlcersVivian Yih, BSc(Pharm) and Aaron Tejani, BSc(Pharm), PharmDVivian Yih, BSc(Pharm)From Fraser Health, Surrey, British Columbia V3R 7P8, Canada.Search for more papers by this author and Aaron Tejani, BSc(Pharm), PharmDFrom Fraser Health, Surrey, British Columbia V3R 7P8, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-8-200910200-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their article on prevention of recurrent ulcer bleeding, Sung and colleagues (1) conclude that theirs is the first international trial supporting the efficacy of high-dose intravenous proton-pump inhibitor (PPI) therapy in white patients with acute peptic ulcer bleeding. We have several concerns with this statement. First, Sung and colleagues' initial intent was to study a multiethnic population, which would have been enlightening because trials to date have only focused on Asian and non-Asian populations. However, this trial was primarily composed of white participants. This population has been studied many times before (13 trials in 3219 patients) ...References1. Sung JJ, Barkun A, Kuipers EJ, Mössner J, Jensen DM, Stuart R, et al; Peptic Ulcer Bleed Study Group. Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding: a randomized trial. Ann Intern Med. 2009;150:455-64. [PMID: 19221370] LinkGoogle Scholar2. Leontiadis GI, Sharma VK, Howden CW. Proton pump inhibitor treatment for acute peptic ulcer bleeding. Cochrane Database Syst Rev. 2006;:CD002094. [PMID: 16437441] MedlineGoogle Scholar3. Yilmaz S, Bayan K, Tüzün Y, Dursun M, Canoruç F. A head to head comparison of oral vs intravenous omeprazole for patients with bleeding peptic ulcers with a clean base, flat spots and adherent clots. World J Gastroenterol. 2006;12:7837-43. [PMID: 17203530] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Vivian Yih, BSc(Pharm); Aaron Tejani, BSc(Pharm), PharmDAffiliations: From Fraser Health, Surrey, British Columbia V3R 7P8, Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIntravenous Esomeprazole for Prevention of Recurrent Peptic Ulcer Bleeding Joseph J.Y. Sung , Alan Barkun , Ernst J. Kuipers , Joachim Mössner , Dennis M. Jensen , Robert Stuart , James Y. Lau , Henrik Ahlbom , Jan Kilhamn , Tore Lind , and Missed Opportunities in the Trial on Proton-Pump Inhibitor Therapy in Bleeding Peptic Ulcers Hwai-Jeng Lin and Yao-Chun Hsu Missed Opportunities in the Trial on Proton-Pump Inhibitor Therapy in Bleeding Peptic Ulcers Alejandro Piscoya Missed Opportunities in the Trial on Proton-Pump Inhibitor Therapy in Bleeding Peptic Ulcers Joseph J.Y. Sung , Alan Barkun , and Ernst J. Kuipers Metrics 20 October 2009Volume 151, Issue 8Page: 588-589KeywordsConflicts of interestHemorrhageMortalityPeptic ulcersProton pump inhibitorsSurgery ePublished: 20 October 2009 Issue Published: 20 October 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...