AJH Hematology Crossword Puzzle, August 2010
Authors: David P. Steensma
Journal: American Journal of Hematology (2010)

Across 1 A common intrathoracic adverse effect of dasatinib therapy 5 Cell type that arises when preparing a blood smear from a patient with chronic lymphocytic leukemia, probably because of low expression of vimentin, a component of the cytoskeleton 10 Nautrally occuring thrombin inhibitor in the salivary glands of leeches that is the basis of several anticoagulant medications 11 Action a patient must undertake to ensure a complete physical exam 12 Prominent Boston physician who founded the field of social work, and in 1903 described threadlike red cell inclusions that take the shape of a loop or figure 8 and can be seen in megaloblastic anemia 14 Insulin secretagogue that is a synthetic version of exendin 4, a hormone found in the saliva of the Gila monster; approved by the FDA for use in diabetes mellitus in 2005 16 An obsolete test of platelet and vascular function that involved cutting the patient's forearm (2 words) 19 Antiplatelet drug derived from the venom of the southeastern pygmy rattlesnake 25 Antiplatelet drug based on an anticoagulant found in the venom of the saw-scaled viper 27 Eponym for the extremely high oxygen-affinity hemoglobin that is comprised of four gamma globin chains, and is found in the most severe form of alpha thalassemia 28 A 1955 article by Henry Beecher suggested 35% of people will report improved symptoms after taking this type of sham medication; name comes from the Latin for “I shall please” 30 The subsalicylate form of this metal is pink, and useful therapy for minor indigestion 32 New York surgeon who injected bacterial extracts into lymphoid tumors in the 1890s, inducing remissions - an early form of cancer immunotherapy 33 Carbonated beverage originally brewed using sassafras Down 1 Branch of philosophy that deals with morality; applied forms are frequently discussed when considering difficult or controversial medical decisions 2 Merseyside town that was the site of the first lifeboat station in the world, dating back to the late 1700s 3 Acronym for the disorder that results from a substitution of valine for glutamate as the sixth amino acid of the beta globin chain 4 To possess or belong to 6 Substances- liquids, solids, or gels - used for cultivating cells or microorganisms in the laboratory 7 Aniline purple (mauveine) was the first synthetic example of this class of substance, discovered by William Henry Perkin in 1856; many other such textile staining substances, such as Congo red, eventually became histological stains 8 The most common stelar arrangement in stems of plants, in which the vascular tissue is arranged in vascular bundles around a central pith; an obscure term shamelessly chosen because it was the only one that fit in this corner of the puzzle 9 Breaking these upper arm bones is not a laughing matter… 13 Gene on chromosome 12p13 that is rearranged in the most common balanced translocation found in pediatric acute lymphoid leukemia 14 When evolution's skeptics want to attack Darwinism, they often point to the improbability of this complex special sensory organ, but zoologist Dan-Erik Nilsson has demonstrated how it could have evolved through natural selection acting on small variations 15 Randomized clinical trial that demonstrated superiority of imatinib to interferon and cytarabine therapy for patients with chronic myeloid leukemia (acronym) 17 Watson and Crick's 1953 Nature paper describing the helical structure of this molecule was only 900 words; many authors have used much more space to say much less 18 The plots that describe the color-magnitude relationship for most of these luminous balls of plasma are known as Hertzsprung–Russell diagrams 19 Descriptor for something that is not in its proper place, e.g. an organ or a pregnancy 20 In CD34+ cells from this Old World primate, 96% of genes are expressed at similar levels to humans 21 Skin color change prompted by exposure to ionizing radiation with wavelengths of 280 to 400 nm; businesses that provide customers with this attractive but dangerous skin change are subject to new taxes as part of the 2010 U.S. Health Care Reform 22 Hospitalized patients are asked for this piece of personal information many times each day, in order to confirm their identity and maximize safety (acronym) 23 As a test for splenomegaly, percussion over this eponymous semilunar subcostal space yields a sensitivity of 62% and specificity 72% 24 Scab seen in echthyma gangrenosum, anthrax, and brown recluse spider bites 26 _____ Jacques, one of the most widely recognized songs on earth, was incorporated by Gustav Mahler into his Symphony No. 1 29 Acronym for a highly active drug in acute promyelocytic leukemia 30 Greek prefix denoting “life” 31 Standardized test of verbal and mathematical skills that American secondary school students must take to gain admission to a competitive university (acronym)