tbuckley/cabot-search huggingface dataset:
Randomized Phase I Chemoprevention Dose-Seeking Study of -Difluoromethylornithine
Authors: R. R. Love, P. P. Carbone, A. K. Verma, D. Gilmore, P. Carey, K. D. Tutsch, M. Pomplun, G. Wilding
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Randomized Phase I Chemoprevention Dose-Seeking Study of α-Difluoromethylornithine Get access Richard R. Love, Richard R. Love 1University of Wisconsin Comprehensive Cancer CenterMadison, Wis * Correspondence to: Richard R. Love, M.D., University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792. Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul P. Carbone, Paul P. Carbone 1University of Wisconsin Comprehensive Cancer CenterMadison, Wis Search for other works by this author on: Oxford Academic PubMed Google Scholar Ajit K. Verma, Ajit K. Verma 1University of Wisconsin Comprehensive Cancer CenterMadison, Wis Search for other works by this author on: Oxford Academic PubMed Google Scholar Debra Gilmore, Debra Gilmore 1University of Wisconsin Comprehensive Cancer CenterMadison, Wis Search for other works by this author on: Oxford Academic PubMed Google Scholar Patrick Carey, Patrick Carey 1University of Wisconsin Comprehensive Cancer CenterMadison, Wis Search for other works by this author on: Oxford Academic PubMed Google Scholar Kendra D. Tutsch, Kendra D. Tutsch 1University of Wisconsin Comprehensive Cancer CenterMadison, Wis Search for other works by this author on: Oxford Academic PubMed Google Scholar Marcia Pomplun, Marcia Pomplun 1University of Wisconsin Comprehensive Cancer CenterMadison, Wis Search for other works by this author on: Oxford Academic PubMed Google Scholar George Wilding George Wilding 2William S. Middleton Memorial Veterans HospitalMadison, Wis Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 9, 5 May 1993, Pages 732–737, https://doi.org/10.1093/jnci/85.9.732 Published: 05 May 1993 Article history Received: 21 September 1992 Revision received: 27 January 1993 Accepted: 01 February 1993 Published: 05 May 1993
Infant Feeding: Anatomy of a Controversy 1973-1984
Authors: Laurence Finberg
Journal: JAMA (1989)

This book gives a history of the boycott of the product of a major infant formula company, Nestle, with extension of the boycott to include the company's other products during the period from 1973 through 1984. At the time the book was written and published in early 1988, it seemed that the episode had been completed. Subsequent to the book's publication, however, the boycott has been resumed by some of the previous instigators and now extends to another company, American Home Products, as well. The author/editor of the book purports to give an evenhanded discussion of the opposing sides in the issue. He is joined by two professional writers who covered events as reporters and now add chapters with their interpretations. There is also a foreword by Frank Falkner, who echoes the spirit and conclusions of the book. Both Drs Dobbing and Falkner have served in the recent past as
Addisonian Pernicious Anaemia in Young Bantu Females
Authors: J. Metz, T. W. Randall, C. H. Kniep
Journal: BMJ (1961)

Addisonian pernicious anaemia occurs predominantly in middle-aged subjects.The disease is rarely seen in young adults; thus 46 (2.8%) of Wilkinson's (1949) 1,600 patients and 4 (1.2%) of Wintrobe's (1946) 329 patients were less than 30 years of age.The disease, although uncommon in negro populations, has been reported in the Bantu (Woods and Rymer, 1955;Adams, 1957; Metz et al., 1958).In the largest Bantu series reported (Metz et al., 1958), a tendency to affect a younger age-group was noted, but the numbers were too small to compare with the large series reported in whites.Megaloblastic anaemia in Bantu adults occurs pre- dominantly in young females, and is usually associated with pregnancy.In this form the serum vitamin B,,
Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin
Authors: C. Johansen, P.A. Usher, R.B. Kjellerup, D. Lundsgaard, L. Iversen, K. Kragballe
Journal: British Journal of Dermatology (2009)

Th17 cells are a lineage of proinflammatory T helper cells producing interleukin (IL)-17. The importance of Th17 cells in inflammation and autoimmunity has now been recognized. The IL-17 cytokine family consists of six isoforms (IL-17A-IL-17F) whereas five members of the IL-17 receptor (IL-17R) family have been identified (IL-17RA-IL-17RE).To characterize the expression of the IL-17 isoforms and receptors in lesional and nonlesional psoriatic skin. Methods Keratome and punch biopsies taken from patients with psoriasis were examined by enzyme-linked immunosorbent assay and quantitative reverse transcription-polymerase chain reaction in order to measure the IL-17 isoforms and receptors.We demonstrated significantly increased mRNA expression of IL-17A, IL-17C and IL-17F in psoriatic skin. In contrast, the mRNA expression of IL-17B and IL-17D was significantly decreased in lesional compared with nonlesional skin, while IL-17E mRNA was undetectable. The increased mRNA expression of IL-17A, IL-17C and IL-17F was paralleled by an increased protein accumulation of these cytokines in psoriatic skin. Analysis of the IL-17R mRNA expression revealed significantly impaired mRNA expression of IL-17RB, IL-17RC, IL-17RD and IL-17RE in lesional psoriatic skin, whereas the mRNA expression of IL-17RA was similar in lesional and nonlesional psoriatic skin.This study characterizes the mRNA profile of the IL-17 isoforms and receptors in psoriatic skin lesions. Furthermore, we demonstrate for the first time augmented protein levels of IL-17A, IL-17C and IL-17F in psoriatic skin lesions, indicating a possible role for IL-17C in addition to IL-17A and IL-17F in the pathogenesis of psoriasis.
Conservation of Cervix in Operations for Prolapse
Authors: J. W. A. Hunter
Journal: BMJ (1939)

In reviewing current methods in gynaecology one observes a persisting hesitation to practise the first principle of surgery-preservation of function.A distinction should ever be drawn between women of child-bearing age and those no longer capable of reproduction.In the former, preservation or restoration of function should be our aim; in the latter, certain cure of symptoms by radical means is justifiable.There is a persistent hesitation to adopt planned conservative measures lest symptomatic relief shoulld be incomplete, and there is failure to count the cost at which a radical cure may be purchased.Avoid- able hysterectomies are still being performed for " tarry cysts," pus tubes, and even fibroids in comparatively young women, although many successful pregnancies after con- servative treatments have been recorded.The earl'y masters in gynaecology were careful to pre- serve this distinction between case groups.In prolapse they tended to operate only in the more severe cases usually associated with older women, while pessary treat- ment was employed for the minor degrees of prolapse found in younger patients.They were conservative, too, in thieir attitude to lacerations and diseases of the cervix.The apparent suLccess of amputation of the cervix, with or without colporrhaphy, may have caused the pendulum to swing too far in the direction of radical surgical treat- ment, and it is worth while to analyse some of the harmful after-effects of this change.Modern technique has brought with it wider'accomplishment and greater safety, but it has also brought new dangers and new problems.Cervical Amputation Cervical amputation was first widely practised by the French surgeons.Huguiier, stimulated by the work of Lisfranc, adopted amputation as a routine measure in all -cases of procidentia.Marion Sims in 1866 advocated the operation not only for prolapse but also for hypertrophy and disease of the cervix.Sims believed that the opera- tion did not interfere with child-bearing, and quoted two cases of normal pregnancy and labour after his operation.T. A. Emmet in 1869 reported his operation of trachelor- rhaphy which he had devised in 1862.Twenty years later, however, he advocated amputation after the manner of Sims for many cases in preference to repair, partly because it was an easier operation and partly because of its more curative effect on symptoms.He then stated that ampu- tation had no effect on fertility, pregnancy, or labour.J. D. Emmet in 1895 advocated a return to trachelor- rhaphy in view of the ill effects sometimes found after amputation, a view contradicted by T. A. Emmet in 1897.Meanwhile Schroeder in 1878 and 1880 had devised and reported on 220 cases operated on by his method of circular amputation with every appearance of success.About this time amputation of the cervix came to be associated with colporrhaphy as an operation for pro- lapse.In 1888 Cohn reported 105 cases of prolapse so treated by Olshausen and Schroeder, and about the same time Donald independently devised a similar treatment.
IMPACT OF HOSPITAL AND SOCIO-DEMOGRAPHIC FACTORS ON DRUG-ELUTING STENT USE IN THE 2011-2012 MEDICARE COHORT: CHOICES, CHANCES, CHANGES
Authors: Tushar A. Tuliani, Maithili Shenoy, Milind Parikh, Mauricio Cohen, Cindy Grines, Anthony Hilliard
Journal: Journal of the American College of Cardiology (2015)
Intensity of Statin Therapy in Relation to Myocardial Ischemia, Troponin T Release, and Clinical Cardiac Outcome in Patients Undergoing Major Vascular Surgery
Authors: Harm H.H. Feringa, Olaf Schouten, Stefanos E. Karagiannis, Jasper Brugts, Abdou Elhendy, Eric Boersma, Radosav Vidakovic, Marc R.H.M. van Sambeek, Peter G. Noordzij, Jeroen J. Bax, Don Poldermans
Journal: Journal of the American College of Cardiology (2007)
COLORING MATTERS AND FERMENTS.
Authors: J. F. PEAVY
Journal: JAMA (1898)

No other generalization which the human mind has reached has done so much to bind in organic unity the phenomena of the physical universe as the law of conservation and correlation of forces. It has helped very largely, too, to clear our thinking of many vague and unscientific notions. Among these is the notion of a vital principle or force. Science now substitutes the more definite and logical conception of organization, itself, accomplished through natural means, appropriating, co-ordinating and directing natural forces. In the light of this law, the phenomena of organic nature in their physical aspects become interpretable as incidents in the ceaseless redistributions of matter and motion, of which all organic changes consist. Vital changes are natural phenomena, and are linked in by physical bonds with the successions of nature. The forces through which life manifests itself are drawn from and returned to the common stock in nature.
Diet and overall survival in elderly people
Authors: A. Trichopoulou, A. Kouris-Blazos, M. L Wahlqvist, C. Gnardellis, P. Lagiou, E. Polychronopoulos, T. Vassilakou, L. Lipworth, D. Trichopoulos
Journal: BMJ (1995)

To assess the influence of a specific dietary pattern on overall survival.Cohort study.Three rural Greek villages, the data from which were collected as part of an international cross cultural study of food habits in later life.182 elderly residents of the three villages.Overall mortality.Diet was assessed with a validated extensive semiquantitative questionnaire on food intake. A one unit increase in diet score, devised a priori on the basis of eight component characteristics of the traditional common diet in the Mediterranean region, was associated with a significant 17% reduction in overall mortality (95% confidence interval 1% to 31%).A diet meeting currently understood health criteria does predict survival among people.
Monocyte transferrin‐iron uptake in hereditary hemochromatosis
Authors: Delton J. Sizemore, Mark L. Bassett
Journal: American Journal of Hematology (1984)

Abstract Transferrin‐iron uptake by peripheral blood monocytes was studied in vitro to test the hypothesis that the relative paucity of mononuclear phagocyte iron loading in hereditary hemochromatosis results from a defect in uptake of iron from transferrin. Monocytes from nine control subjects and 17 patients with hemochromatosis were cultured in the presence of 59 Fe‐labelled human transferrin. There was no difference in 59 Fe uptake between monocytes from control subjects and monocytes from patients with hemochromatosis who had been treated by phlebotomy and who had normal body iron stores. However, 59 Fe uptake by monocytes from iron‐loaded patients with hemochromatosis was significantly reduced compared with either control subjects or treated hemochromatosis patients. It is likely that this was a secondary effect of iron loading since iron uptake by monocytes from treated hemochromatosis patients was normal. Assuming that monocytes in culture reflect mononuclear phagocyte iron metabolism in vivo, this study suggests that the relative paucity of mononuclear phagocyte iron loading in hemochromatosis is not related to an abnormality in transferrin‐iron uptake by these cells.
Drug Prescribing in Renal Failure: Dosing Guidelines for Adults.
Authors: W M Bennett, G R Aronoff, G Morrison, T A Golper, J Pulliam, M Wolfson, I Singer
Journal: Annals of Internal Medicine (1988)

The data base for rational guidelines to safe, efficacious drug prescribing in adults with renal insufficiency are presented in tabular form. Current medical literature was extensively surveyed to provide as much specific information as possible. When information is lacking, however, recommendations are based on pharmacokinetic variables in normal subjects. Nephrotoxicity, important adverse effects, and special considerations in renal patients are noted. Adjustments are suggested for hemodialysis and peritoneal dialysis when appropriate.
Relation between right ventricular mass and cavity size: an analysis of 1500 human hearts.
Authors: L G Horan, N C Flowers, C J Havelda
Journal: Circulation (1981)

We examined data on the mass, area and myocardial abnormality (scar or infarction) of the right ventricular free wall (RVFW) from 1500 consecutive dissections of hearts that came to autopsy. There were 447 hearts with associated coronary and ischemic heart disease (CAD) and 826 without CAD. RVFW mass was used as an index of hypertrophy (RVH) and RVFW area was used as an index of dilatation (RVD). In both groups of hearts, RVH and RVD were strongly correlated and can be properly referred to as one entity: right ventricular enlargement (RVE). Right ventricular infarction occurred both with and without RVE but rarely without CAD. Right ventricular infarction usually assumed an apical or basal pattern of distribution parallel to that of the adjacent left ventricular lesion.
Prevalence and risk factors for hepatitis C virus infection at an Urban veterans administration medical center
Authors: Megan E. Briggs, Christiane Baker, Robert Hall, Michael J. Gaziano, David Gagnon, Natalie Bzowej, Teresa L. Wright
Journal: Hepatology (2001)

This study was designed to determine the seroprevalence and risk factors for hepatitis C virus (HCV) infection in veterans. Anti-HCV testing was performed in 1,032 patients and a questionnaire regarding sociodemographic characteristics and potential risk factors was administered. Adjusted prevalence of unique HCV-positive patients using outpatient services was 17.7% (95% confidence interval [CI] 17.2%, 18.2%). The following risk factors were associated with HCV infection: a history of injection drug use (IDU), receipt of blood transfusion prior to 1992, history of tattoo (odds ratio [OR], 2.93; 95% CI, 1.70-5.08), combat job as a medical worker (OR, 2.68; 95% CI, 1.25-5.60), history of incarceration over 48 hours (OR, 2.56; 95% CI, 1.52-4.32), greater than 15 lifetime sexual partners (OR, 1.61; 95% CI, 0.94-2.76) and sexual relations with a prostitute (OR, 0.46; 95% CI, 0.25-0.82). We concluded that HCV is common in veterans. Risk factors independently associated with infection are IDU, prior transfusion, prior tattoo, combat medical work, incarceration, and multiple opposite sex partners. Infection with HCV among veterans is strongly associated with traditional risk factors for infection and less strongly associated with combat-related risk.
P82 Haemoglobin level prior to liver transplantation: does it predict the outcome?
Authors: N. Kamperidis, M. A. B. Al-Freah, M. A. Heneghan, N. Heaton, J. R. Goodhand, J. O'Grady
Journal: Gut (2011)

<h3>Introduction</h3> Approximately 75% of patients with chronic liver disease have anaemia secondary to iron deficiency, haemorrhage, haemolysis, reduced erythropoiesis, hypersplenism, drugs or haemodilution. In other specialties (cardiac and renal) it has been proven that pre-transplant anaemia impacts negatively on both patient and graft survival. This has not been studied in liver graft recipients. <h3>Aim</h3> To define whether pre-transplant Hb levels impact on the 5-year survival and the need for re-transplantation. <h3>Method</h3> Retrospective study of all patients who had liver transplantation (LT) at our centre between 1 August 1988 and 1 August 1999. Patients were included if they had a pre-LT haemoglobin (Hb) level recorded and 5-year follow-up available. Hb is expressed in g/dl. In order to define a survival threshold, patients were classified according to their Hb levels (Hb&lt;8, Hb=8–10, Hb=10–12, Hb&gt;12). Statistical analysis was performed using χ<sup>2</sup> test, Kaplan–Meier and Student t test. <h3>Results</h3> 720 patients were included. Mean age [SEM] was 37 [0.6]. Males were 349/720 (49%). 198 patients had Hb&gt;12 g/dl, 318 had Hb between 10 and 12 g/dl, 182 had Hb 8–10 g/dl and 22 had Hb &lt;8 g/dl. Mean age of each group was 41 [1.1], 37 [1.0], 34 [1.3], 24 [3.2] (p&lt;0.01) respectively. The 5-year survival was 60%, 63%, 50% and 59% respectively (p&lt;0.05). There was no difference between these Hb groups in relation to the need for retransplant. Using a Hb level of 10 g/dl as a cut-off value, a Kaplan–Meier survival analysis (see Abstract P82 figure 1) showed that survival was significantly improved in patients with a pre-LT level of ≥10 g/dl (p&lt;0.01). Simultaneous multi-variate binary logistic regression [OR, (CI), p value] showed that age [0.98, (0.97 to 0.99), &lt;0.01], Hb≥10 [1.6, (1.2 to 2.3), &lt;0.01] and a diagnosis of PBC [2.5, (1.3 to 4.6), &lt;0.01] could predict the 5-year survival post-LT. <h3>Conclusion</h3> This study demonstrates a significantly worse 5-year survival in patients with pre-LT Hb&lt;10 g/dl. Prospective randomised trials to study the impact of correction of pre-LT Hb&lt;10 g/dl on the long-term survival is required to define a treatment strategy.
Gene Expression of Angiogenic Factors Correlates with Metastatic Potential of Prostate Cancer Cells
Authors: Ravikumar Aalinkeel, Madhavan P. N. Nair, Gerald Sufrin, Supriya D. Mahajan, Kailash C. Chadha, Ram P. Chawda, Stanley A. Schwartz
Journal: Cancer Research (2004)

Abstract We hypothesize that expression of proangiogenic genes correlates with the metastatic potential of prostate cancer cells. LNCaP, DU-145, and PC-3 are prostate cancer cell lines with low, moderate, and high metastatic potential, respectively, as we demonstrated by their capacity to invade an extracellular matrix, an established tumor invasion assay. The constitutive gene expression of the proangiogenic factors, vascular endothelial growth factor, intercellular adhesion molecule-1, interleukin-8, and transforming growth factor-β2, was significantly greater in the more metastatic DU-145 and PC-3 cells as compared with LNCaP cells. Matrix metalloproteinase (MMP)-9 is thought to contribute to the invasive phenotype of tumor cells. PC-3 cells showed increased expression of MMP-9 and membrane type 4-MMP as compared with LNCaP and DU-145. Tissue inhibitors of metalloproteinase 1 and 4 gene expression were elevated in DU-145 and PC-3 cells, but paradoxically, LNCaP cells had undetectable levels of these genes. We transfected and overexpressed MMP-9 in poorly metastatic LNCaP cells and measured their invasive activity. Transient expression of human MMP-9 in LNCaP cells produced a 3–5-fold increase in MMP-9 activity with a comparable increase in invasiveness. Antisense ablation of the expression of MMP-9 in DU-145 and PC-3 cells produced concomitant inhibition of the gene expression of the proangiogenic factors, vascular endothelial growth factor, and intercellular adhesion molecule-1 (ICAM-1). Treatment of DU-145 and PC-3 cells with a selective chemical inhibitor of MMP-9 proteinase activity also inhibited their invasive activity. These results support our hypothesis that metastatic potential of prostate cancer cells correlates with expression of proangiogenic factors.
Hannah's Heirs: The Quest for the Genetic Origins of Alzheimer's Disease
Authors: A. Mark Clarfield
Journal: JAMA (1994)

Most readers ofThe Journalwill not need to be reminded of the devastation wrought by Alzheimer's disease. This killer has as yet no effective therapy, and all of its victims eventually succumb, falling into "second childishness, and mere oblivion." Despite its apparent ubiquity both in time and place, the most common form of dementia was only described and reported in the early years of this century by the German neurologist Alois Alzheimer. Only in the last 20 years has there been evidence of widespread scientific interest in the problem. A small number of those afflicted with Alzheimer's disease manifest the early-onset (fifth and sixth decade), genetically transmitted form of the disease. This book describes the story of one affected Jewish family whose ancestors left Eastern Europe for the New World in the great wave of immigration around the turn of the century. The author, a neurologist, recounts how he
Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles
Authors: Vibeke Andresen, Cynthia A. Pise-Masison, Uma Sinha-Datta, Marcia Bellon, Valerio Valeri, Robyn Washington Parks, Valentina Cecchinato, Risaku Fukumoto, Christophe Nicot, Genoveffa Franchini
Journal: Blood (2011)
VENTILATION/PERFUSION LUNG IMAGING IN PULMONARY EMBOLISM
Authors: Lalitha Ramann, Alan D. Waxman, Michael B. Brachman, Dhana Kaushik, Peter Julien, Daniel S. Berman, Doina Tanasescu
Journal: Clinical Nuclear Medicine (1983)

Ramann, Lalitha; Waxman, Alan D.; Brachman, Michael B.; Kaushik, Dhana; Julien, Peter; Berman, Daniel S.; Tanasescu, Doina Author Information
EFFECT OF STIMULATION OF SENSORY NERVES UPON THE RATE OF LIBERATION OF EPINEPHRIN FROM THE ADRENALS
Authors: G. N. Stewart, J. M. Rogoff
Journal: The Journal of Experimental Medicine (1917)

An attempt was made to determine whether stimulation of afferent nerves (sciatic and brachial) produced a detectable increase in the rate of liberation of epinephrin from the adrenals, as determined by testing adrenal vein blood on rabbit intestine and uterus segments. The result was negative.
Lowinson and Ruiz’s Substance Abuse: A Comprehensive Textbook
Authors: Philip E. Veenhuis
Journal: JAMA (2012)

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