tbuckley/cabot-search huggingface dataset:
The Physio-Medical School?
Authors: B. H. Putnam
Journal: JAMA (1897)

North East, Pa., March 15, 1897. <h3>To the Editor:</h3> —Can you give through the columns of your valuableJournala short history of what is known hereabouts as the physio-medical school of the practice of medicine. I would like to know something as to its origin, wherein it differs from the Regular, how many colleges it has, and as to what States recognize it as a<i>separate school</i>, and especially as to whether any State law names a physio-medical practitioner as one of the legal examiners for that school upon any State Medical Examining Board? This may seem to be a long string of wants, but I am anxious to have it answered, as I see you are in the business of exposing humbugs. The following is my reason for asking you for the above information. We have near here a physio-medical practitioner who has never been before our State
Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes
Authors: Carola M. Rosseland, Lene Wierd, Morten P. Oksvold, Heidi Werner, Anne Carine stvold, Hege G. Thoresen, Ragnhild E. Paulsen, Henrik S. Huitfeldt, Ellen Skarpen
Journal: Hepatology (2005)

Reactive oxygen species (ROS) are implicated in tissue damage causing primary hepatic dysfunction following ischemia/reperfusion injury and during inflammatory liver diseases. A potential role of extracellular signal-regulated kinase (ERK) as a mediator of survival signals during oxidative stress was investigated in primary cultures of hepatocytes exposed to ROS. Hydrogen peroxide (H(2)O(2)) induced a dose-dependent activation of ERK, which was dependent on MEK activation. The ERK activation pattern was transient compared with the ERK activation seen after stimulation with epidermal growth factor (EGF). Nuclear accumulation of ERK was found after EGF stimulation, but not after H(2)O(2) exposure. A slow import/rapid export mechanism was excluded through the use of leptomycin B, an inhibitor of nuclear export sequence-dependent nuclear export. Reduced survival of hepatocytes during ROS exposure was observed when ERK activation was inhibited. Ribosomal S6 kinase (RSK), a cytoplasmic ERK substrate involved in cell survival, was activated and located in the nucleus of H(2)O(2)-exposed hepatocytes. The activation was abolished when ERK was inhibited with U0126. In conclusion, our results indicate that activity of ERK in the cytoplasm is important for survival during oxidative stress in hepatocytes and that RSK is activated downstream of ERK. Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html).
Catheter ablation of the atrioventricular junction: a report of the percutaneous mapping and ablation registry.
Authors: M M Scheinman, T Evans-Bell
Journal: Circulation (1984)

An international registry was formed to collate data for patients undergoing attempted catheter ablation of the atrioventricular (AV) junction and insertion of a permanent pacemaker. Over the past 2 years, data was submitted for 127 patients who were followed for a mean of 9.9 +/- 8.2 months. The most common arrhythmia treated was chronic or paroxysmal atrial fibrillation or flutter (78 patients, 61%); the remainder had supraventricular tachycardia due to AV node reentry, ectopic atrial tachycardia, or incorporated an accessory pathway. A single shock of 150 to 400 J was effective in producing chronic third-degree AV block in 45 patients while two or more shocks were used in an additional 45 patients. There was no significant difference in the total cumulative energy used in successful and unsuccessful procedures. Immediate complications related to the shock included ventricular fibrillation (one patient), pericardial tamponade (one patient), and transient hypotension (one patient). No chronic sequelae occurred as a result of these complications. Late complications (1 day to 1 month) included ventricular tachycardia (three patients), sepsis involving the pacemaker pocket (two patients), staphylococcal sepsis from temporary pacing catheter (one patient), thrombophlebitis (one patient), thrombosis of the left subclavian vein (one patient), and hemothorax (one patient). Follow-up evaluation revealed chronic third degree AV block in 90 (71%) and AV conduction resumed but no drugs were required for arrhythmia control in eight (6.5%) and arrhythmia control was achieved with previously ineffective drugs in 16 (13%). Thirteen patients (10%) had no improvement and five of these patients underwent cardiac electrosurgery for direct His bundle ablation.(ABSTRACT TRUNCATED AT 250 WORDS)
Fully Automated Artificial Pancreas Finally Within Reach
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A case of factor V inhibitor with complete correction of the PT and aPTT upon mixing
Authors: Jay Lipshitz, Thandavababu Chelliah, Louis Aledort
Journal: American Journal of Hematology (2011)

We read with interest Gartrell's recent report of a woman who developed a factor V inhibitor. Gartrell noted in his report that the inhibitor appeared to exhibit time dependence, as the mixing study showed slightly more prolongation of both the PT and the aPTT after 1 hr than immediately following mixing. We believe Gartrell's article may shed light on a recent intriguing case of a patient with factor V inhibitor at our institution.
Skin Cancer Incidence: The Effects of Surveillance and Migration-Reply
Authors: Robert N. Hoover
Journal: JAMA (1990)

<h3>In Reply. —</h3> Dr Stern raises some interesting points. Although the changes in "sun exposure habits" may have been gradual, the rises in incidence have been major. Indeed, sizable rises in melanoma rates in other registries antedate our study by several decades. In Connecticut, the incidence of melanoma (among males and females combined) rose from 1.0 per 100 000 to 3.6 per 100 000 in the 25 years between 1935 through 1939 and 1960 through 1964.<sup>1</sup>Until this cancer became relatively common, such rises in incidence were ignored. Changes in incidence of squamous cell skin cancer went unreported, as data were not collected by registries. Interviews with clinicians who have been present over most of the study period revealed no changes in clinical practice with respect to management of skin lesions. However, we have no objective, quantifiable data to address this issue. Further, we note in the text that
Congenital left ventricular inflow obstruction evaluated by two-dimensional echocardiography.
Authors: A R Snider, C L Roge, N B Schiller, N H Silverman
Journal: Circulation (1980)

Several forms of congenital heart disease that cause left ventricular inflow obstruction have similar M-mode findings, and frequently the exact anatomic diagnosis cannot be made by M-mode echocardiography alone. We examined five children with various forms of left ventricular inflow obstruction using two-dimensional echocardiography. The diagnosis was confirmed by cardiac catheterization and surgery in all five patients. In one patient with congenital mitral valve stenosis, a thick mitral valve with two papillary muscles was imaged. This patient was easily distinguished from a second child with parachute deformity of the mitral valve in whom a single papillary muscle arising from the left ventricular apex was seen. These two patients with mitral valve stenosis were easily differentiated from the three patients in whom the left ventricular inflow obstruction was caused by a membrane within the left atrium. The membrane could be seen in several spatial planes; however, we could not distinguish by two-dimensional echocardiography one child who had cor triatriatum from the other two patients who had a supravalvar mitral ring. Because of its spatial anatomic display, the two-dimensional echocardiogram provides information for a more detailed anatomic diagnosis in children with congenital left ventricular inflow obstruction.
Sudden Cardiac Death in the United States, 1989 to 1998
Authors: Zhi-Jie Zheng, Janet B. Croft, Wayne H. Giles, George A. Mensah
Journal: Circulation (2001)

Background Sudden cardiac death (SCD) is a major clinical and public health problem. Methods and Results United States (US) vital statistics mortality data from 1989 to 1998 were analyzed. SCD is defined as deaths occurring out of the hospital or in the emergency room or as “dead on arrival” with an underlying cause of death reported as a cardiac disease (ICD-9 code 390 to 398, 402, or 404 to 429). Death rates were calculated for residents of the US aged ≥35 years and standardized to the 2000 US population. Of 719 456 cardiac deaths among adults aged ≥35 years in 1998, 456 076 (63%) were defined as SCD. Among decedents aged 35 to 44 years, 74% of cardiac deaths were SCD. Of all SCDs in 1998, coronary heart disease (ICD-9 codes 410 to 414) was the underlying cause on 62% of death certificates. Death rates for SCD increased with age and were higher in men than women, although there was no difference at age ≥85 years. The black population had higher death rates for SCD than white, American Indian/Alaska Native, or Asian/Pacific Islander populations. The Hispanic population had lower death rates for SCD than the non-Hispanic population. From 1989 to 1998, SCD, as the proportion of all cardiac deaths, increased 12.4% (56.3% to 63.9%), and age-adjusted SCD rates declined 11.7% in men and 5.8% in women. During the same time, age-specific death rates for SCD increased 21% among women aged 35 to 44 years. Conclusions SCD remains an important public health problem in the US. The increase in death rates for SCD among younger women warrants additional investigation.
Efficacité de la prise en charge endoscopique initiale des cancers du pancréas céphalique obstructifs combinant échoendoscopie avec ponction guidée et appareillage par endoprothèse au cours d'une mêmeanesthésie
Authors: M Camus, I Trouilloud, L Mangialavori, M Gaudric, G Roseau, JC Duchmann, E Mitry, S Chaussade, F Prat
Journal: Endoscopy (2010)

Objectif: Etudier l'efficacité de la réalisation concomitante lors d'une même anesthésie générale d'une échoendoscopie (EEH) avec biopsie et d'une désobstruction biliaire et/ou duodénale endoscopique lors de la prise en charge initiale du cancer du pancréas symptomatique.
Scintigraphic Demonstration of Ectopic Autonomously Functioning Thyroid Adenoma with Normal Cervical Thyroid
Authors: RUTH HARDOFF, ELIZABETH BARON
Journal: Clinical Nuclear Medicine (1990)

Autonomous thyroid tissue commonly appears within the thyroid gland in the cervical region. Ectopic thyroid tissue has been described in the presence of a normal cervical thyroid. The authors describe a patient with thyrotoxicosis in whom an ectopic, retrosternal, autonomous adenoma and a normally appearing, partially suppressed cervical thyroid gland were both demonstrated.
AKA John Smith
Authors: C. L. Frost
Journal: JAMA (1986)

He seemed one of our nicest and most fascinating patients. His hair, tinged russet, hung hung in casual waves over his brow so that only grizzled sideburns betrayed his true age. Sometimes he donned cologne and covered his scant hospital gown with a single-breasted, herringbone jacket, marking him as a man of style and unflinching self-respect. Still, we noticed how the shadows cut deep ravines in his cheeks and how his eyes glimmered with congenial melancholy in sunken, jaundiced sockets; he would gaze at each of us intently, begging our friendship yet inwardly mourning. While other patients whined and demanded attention, he requested care "only at the nurse's convenience" and apologized for bothering us with his "trivial complaints." When we remembered that he had pancreatic cancer, we cursed at how arbitrarily fate chooses its victimes. He had bone metastases and bowel obstruction. He'd been fed intravenously for eight days. Some
The Process of Medical Advance— In Retrospect and Prospect
Authors: Maurice B. Visscher
Journal: JAMA (1965)

Medical advance may, of course, be looked upon from many points of view, but on this occasion of the dedication and inauguration of the new Institute for Biomedical Research of the Education and Research Foundation of the American Medical Association, it would seem appropriate to examine this subject from the point of view of the role of scientific knowledge itself in the advance of medicine, rather than to consider the role of social and other factors affecting the availability of the fruits of that knowledge to humanity. Moreover, practical medicine will be assumed to be the artful application of medical science and no great attention will be paid to advances in such artfulness in practice, partly because ethical physicians, from the days of Hippocrates, have always applied existing contemporary medical science at any given time with skill and devotion, and second, because what changes in the so-called art of medicine
True 3-Dimensional Reconstruction of Coronary Arteries in Patients by Fusion of Angiography and IVUS (ANGUS) and Its Quantitative Validation
Authors: Cornelis J. Slager, Jolanda J. Wentzel, Johan C. H. Schuurbiers, Jan A. F. Oomen, Jeroen Kloet, Rob Krams, Clemens von Birgelen, Willem J. van der Giessen, Patrick W. Serruys, Pim J. de Feyter
Journal: Circulation (2000)

True 3D reconstruction of coronary arteries in patients based on intravascular ultrasound (IVUS) may be achieved by fusing angiographic and IVUS information (ANGUS). The clinical applicability of ANGUS was tested, and its accuracy was evaluated quantitatively. METHODS AND REUSLTS: In 16 patients who were investigated 6 months after stent implantation, a sheath-based catheter was used to acquire IVUS images during an R-wave-triggered, motorized stepped pullback. First, a single set of end-diastolic biplane angiographic images documented the 3D location of the catheter at the beginning of pullback. From this set, the 3D pullback trajectory was predicted. Second, contours of the lumen or stent obtained from IVUS were fused with the 3D trajectory. Third, the angular rotation of the reconstruction was optimized by quantitative matching of the silhouettes of the 3D reconstruction with the actual biplane images. Reconstructions were obtained in 12 patients. The number of pullback steps, which determines the pullback length, closely agreed with the reconstructed path length (r=0.99). Geometric measurements in silhouette images of the 3D reconstructions showed high correlation (0.84 to 0.97) with corresponding measurements in the actual biplane angiographic images.With ANGUS, 3D reconstructions of coronary arteries can be successfully and accurately obtained in the majority of patients.
“Will I Be Pretty, Will I Be Rich?”: The Missing Self in Antidepressant Commercials
Authors: Serife Tekin
Journal: The American Journal of Bioethics (2013)

This undoubted faith in the integrity of the photograph is often rudely shaken; for while photographs may not lie, liars may photograph. (Hine 1909, 3) In “Ban the Sunset? Nonpropositional Content ...
Uroporphyria caused by ethanol in Hfe(−/−) mice as a model for porphyria cutanea tarda
Authors: Peter R. Sinclair, Nadia Gorman, Heidi W. Trask, William J. Bement, Juliana G. Szakacs, George H. Elder, Dominic Balestra, Jacqueline F. Sinclair, Glenn S. Gerhard
Journal: Hepatology (2003)

Two major risk factors for the development of porphyria cutanea tarda (PCT) are alcohol consumption and homozygosity for the C282Y mutation in the hereditary hemochromatosis gene ( HFE ). To develop an animal model, Hfe knockout mice were treated continuously with 10% ethanol in drinking water. By 4 months, uroporphyrin (URO) was detected in the urine. At 6 to 7 months, hepatic URO was increased and hepatic uroporphyrinogen decarboxylase (UROD) activity was decreased. Untreated Hfe(−/−) mice or wild-type mice treated with or without ethanol did not show any of these biochemical changes. Treatment with ethanol increased hepatic nonheme iron and hepatic 5-aminolevulinate synthase activity in Hfe(−/−) but not wild-type mice. The increases in nonheme iron in Hfe(−/−) mice were associated with diffuse increases in iron staining of parenchymal cells but without evidence of significant liver injury. In conclusion, the results of this study suggest that the uroporphyrinogenic effect of ethanol is mediated by its effects on hepatic iron metabolism. Ethanol-treated Hfe (−/−) mice seem to be an excellent model for studies of alcohol-mediated PCT.
BMA condemns ill treatment of striking doctors in Sudan
Authors: P. Moszynski
Journal: BMJ (2010)

The recent arrests of doctors’ leaders in Sudan and subsequent violent attacks on protestors calling for their release have caused widespread international condemnation.

Last week Amnesty International declared six doctors—arrested for their activities as members of a committee calling for better pay and working conditions—to be “prisoners of conscience” and warned that they are “at risk of torture or other ill treatment.”

A BMA spokesman said that it will be writing to the Sudanese authorities “to express serious concerns about potential violations of the fundamental rights of doctors in the Sudan.”

He said, “Sudanese doctors have been peacefully demonstrating in support of their basic employment rights, and the BMA is extremely worried …
ENDOSYMBIOTIC RELATIONSHIP BETWEEN ANIMAL VIRUSES AND HOST CELLS
Authors: Mario V. Fernandes, Tadeusz J. Wiktor, Hilary Koprowski
Journal: The Journal of Experimental Medicine (1964)

RE cultures infected with a fixed rabies virus were studied. The virus can propagate itself in these cells for an indefinite period of time without interfering with cell growth. The present study characterizes this truly endosymbiotic relationship. Virus-specific antigen was detected in the cytoplasm of each cell by fluorescein-labeled antirabies serum but only 4 to 5 per cent of the cells released infectious virus. All cells undergoing division showed viral antigen throughout the mitotic process. Also, the growth rate, plating efficiency, and morphological characteristics of both the infected and control cultures were identical. No difference was detected between the RE and the RE-CVS cell populations by RNA and DNA labeling experiments, using H(3)-thymidine, and H(3)-uridine. Although antirabies serum effectively inhibited the spread of extracellular virus, it did not interfere with cell-to-cell transmission of the virus during mitosis, in the course of 9 cell transfers during 53 days. RE-CVS cells, when exposed to fresh antirabies serum, lysed completely but inactivated serum had no lytic effect. The addition of fresh hamster complement to the inactivated serum restored its cytolytic properties. The serially passaged RE-CVS virus gradually became less virulent for mice and displayed a weak antigenicity in the mouse protection test. Another feature of the RE-CVS cell system is its resistance to infection with homologous and heterologous viruses despite the apparent absence of an interferon-like substance.
The Effect of Ischemia and Alterations of Heart Rate on Myocardial Potassium Balance in Man
Authors: J. O. PARKER, M. A. CHIONG, R. O. WEST, R. B. CASE
Journal: Circulation (1970)

Myocardial electrolyte balance and lactate metabolism were studied in 30 patients before, during, and after a period of atrial pacing utilizing a continuous automated sampling technic with simultaneous electrocardiographic and hemodynamic observations. Eight patients with coronary artery disease who had no symptoms during pacing and four normal subjects demonstrated myocardial potassium loss but no abnormalities in lactate metabolism, the electrocardiogram, and hemodynamics during pacing. Myocardial potassium loss was correlated with increments in heart rate and was followed by potassium uptake during the post-pacing period. Eighteen subjects developed angina during pacing associated with hemodynamic and electrocardiographic abnormalities. This ischemic group showed significantly greater myocardial potassium loss during pacing than the non-ischemic group, and this was closely associated with myocardial lactate production at a ratio of 1 mEq of potassium being lost for each 2 millimoles of lactate produced. Increased acidity of coronary sinus blood also accompanied potassium loss during ischemia. No significant changes were seen in sodium balance in either group during the study.
e Antigen among male homosexual patients.
Authors: P D Simmons, M N Islam, S Knott, J E Banatvala, M Supran
Journal: BMJ (1977)

e Antigen among male homosexual patients Studies in the USA and UK have shown that hepatitis-B virus (HBV) infection is common among sexually promiscuous people and that male homosexuals have a particularly high frequency of past or current infection with HBV.' 2 We have attempted not only to determine the prevalence of HBsAg and its major subtypes among male homosexual and heterosexual patients but, in order to assess some of the risks to patients' contacts, have also conducted tests to detect such possible markers of virus infectivity as the recently described e antigen, Dane particles, and antibody to the core antigen (anti-HBc).
Contribution of Bone Marrow-Derived Cells to Blood Vessels in Ischemic Tissues and Tumors
Authors: Manish Aghi, E. Antonio Chiocca
Journal: Molecular Therapy (2005)

Vessels are formed during embryonic development through three distinct processes. Angiogenesis and arteriogenesis involve the remodeling of established capillary networks and arterioles, while vasculogenesis involves the differentiation of mesodermal progenitor cells called angioblasts into mature endothelial cells. Until recently, postnatal vessel development was felt to occur exclusively through angiogenesis or arteriogenesis. However, recent studies using experimental tumor and ischemia models have raised controversy regarding whether vasculogenesis occurs in postnatal vessel development, with some studies suggesting the possibility and others refuting it. Here, we summarize the process of embryonic vessel development and review studies investigating the role of postnatal vasculogenesis in vessel formation in adult ischemia and tumors. We then focus on studies in which wild-type and genetically modified vascular progenitor cells have been investigated as possible cellular therapies for tumors or ischemia. We also take note of key issues that will need to be understood about the biology of vasculogenesis before cellular therapies utilizing vascular progenitor cells can be finally taken from the bench to the bedside.