tbuckley/cabot-search huggingface dataset:
Fundus Photography of the Diabetic Retina.
Authors: R. D. Hohl
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Fundus Photography of the Diabetic Retina.R. D. Hohl, M.D.R. D. Hohl, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-787_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRetinal fundus photography has become an accepted means of charting the evolving hemorrhagic, exudative, or neoproliferative lesions, or all of these, which characterize diabetic retinopathy. Since 1967 the eye grounds of approximately 150 diabetic patients have been photographed at Henry Ford Hospital, Detroit, Mich., using this relatively simple technique. Illustrative colored photographs, which provide a permanent record of a patient's retina at a given moment, will be shown to detail the invaluable information in these studies. The prolonged survival of the diabetic and the alarming incidence of blindness being reported among diabetics underscores the usefulness of serial fundus photography as... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. D. Hohl, M.D.Affiliations: Detroit, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 787-787KeywordsBlindnessDiabetic retinopathyLesionsPhotographyRetina ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
DELAYED HYPERSENSITIVITY-TYPE GRANULOMA FORMATION AND DERMAL REACTION INDUCED AND ELICITED BY A SOLUBLE FACTOR ISOLATED FROM SCHISTOSOMA MANSONI EGGS
Authors: Dov L. Boros, Kenneth S. Warren
Journal: The Journal of Experimental Medicine (1970)

A soluble material has been isolated from schistosome eggs which in minute quantities without the addition of adjuvant induces sensitization to a delayed hypersensitivity type of granuloma forming around intact schistosome eggs. This material is secreted by intact eggs and is found in high concentration in the fluid released during the hatching process. When adsorbed to bentonite particles this substance elicits hypersensitivity type granuloma formation in specifically sensitized animals. The granuloma sensitizing factor also both induces and elicits delayed footpad swelling in mice. Quantities which sensitize with respect to these delayed type reactions do not induce antibody formation detectable by a sensitive hemagglutination. technique within the duration of the above experiments.
CARCINOMA OF THE STOMACH: GASTRECTOMY
Authors: R. Jamison
Journal: BMJ (1914)

ifID_A JO_L 5 91 found a detacheA foot.Th.e septum ran we~ge-sliaped to the fundus, 'Which was single.CASE Ir.Mrs. K., aged 27, who had had two pregnancies, five and(I three yvears previously, which terminated normally at term, came at the fourth month complaining of bleeding.The os was closed, and the fundus reached half-way to the umbilicus.She was advised to rest.A mouith later she returned, saying that she felt no life, and that she was niot increasing in size.She 'was asked to come -into hospital, but declined.At Dr. Rogers's instance she returned in February, eight months after the beginning of pregnancy.The fundus was lower than formerly, and she was admitted for the treatment of the missed abortion.'The os was closed, and was dilated with Hegar dilators to 2 cm.A slight tear was noted at the external os, -and on inserting the finger to separate the ovum as far as possible a depression was inoted at the left posterior part of the internal os.Again the idea of rupture suggested itself.Labour did not set in, bluit there was inflammatory infiltration of the right broad ligament, and five days later I decided on the removal of tlle ovum.This was found lying in the cervix, and was fetid.On palpation of the cavity the opening on the left side was foun-id to lead to a second uterinC cavity.The ftnlidus was single, as in the other two cases.
Endocrine factors in pre- and postmenopausal women with hidradenitis suppurativa
Authors: J.H. BARTH, A.M. LAYTON, W.J. CUNLIFFE
Journal: British Journal of Dermatology (1996)

The relationship between hidradenitis suppurativa (HS) and hyperandrogenism is largely based on the finding of an increased free androgen index due to a low sex hormone binding globulin (SHBG). As SHBG is now believed to be regulated by factors that influence body weight, and previous studies were not controlled for body weight, we have re-evaluated the androgen status of female patients with HS. We have studied the endocrine status of 66 women with HS. Twenty-three had acne, and 23 were significantly obese (body mass index: BMI > 30). There was no relationship between obesity and disease duration. Nineteen of 56 women were hirsute. A premenstrual flare in disease activity was reported by 32 women, but this was not related to menstrual disturbances. No consistent relationship was reported with pregnancy. Eight women with HS were menopausal at presentation, and one developed her disease 6 years after the menopause. Plasma androgens in women with HS were compared with controls matched for BMI and hirsuties. There was no difference between HS and controls. Testosterone and dehydroepiandrosterone sulphate were normal in all subjects with HS. In obese subjects, SHBG was reduced, consistent with BMI-matched controls. We have found no supporting evidence for biochemical hyperandrogenism in women with HS when compared with age-, weight- and hirsuties-matched controls. We report the continuation and primary development of HS in postmenopausal women.
Comprehensive Geriatric Oncology
Authors: Kenneth R. Hande
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes6 April 1999Comprehensive Geriatric OncologyKenneth R. Hande, MDKenneth R. Hande, MDVanderbilt University School of Medicine, Nashville, Tennessee.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-7-199904060-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Balducci L, Lyman GH, Ershler WB; eds. 832 pages. Amsterdam: Harwood Academic; 1998. $185.00. ISBN 9057022257. Order phone 201-643-7500.Field of medicine: Oncology and geriatrics.Format: Clothbound book.Audience: Oncologists and geriatricians.Purpose: To assist the practitioner in delivering the best possible care to older patients with cancer, to promote cancer prevention in older persons, and to present a research agenda for geriatric cancer.Content: This multiauthor book contains 60 chapters divided into eight sections. Topics include epidemiology; the biology of aging and cancer; the influence of aging on the prevention, diagnosis, and treatment of cancer; cancer prevention and management ... Author, Article, and Disclosure InformationAffiliations: Vanderbilt University School of Medicine, Nashville, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 April 1999Volume 130, Issue 7Page: 623KeywordsAgingCancer epidemiologyCancer preventionCancer treatmentElderlyGeriatric careGeriatricsLung and intrathoracic tumorsLymphocytic leukemiaPatients ePublished: 15 August 2000 Issue Published: 6 April 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
West Nile Virus — Not a Passing Phenomenon
Authors: Dale L Morse
Journal: New England Journal of Medicine (2003)

As private citizens and as public health professionals, we are enthralled by the new, the unknown, and the catastrophic. This is especially true for epidemics that appear suddenly, spread rapidly, and cause severe illness. History and literature provide many examples of how the effects of microbes have helped to win and lose wars and to make and break governments, mesmerizing the media and the public. Unfortunately, despite successful battles against microbial diseases early in the 20th century, the oft-repeated declaration that the war had been won was premature. The resulting decline in preparedness was followed by a resurgence of infectious . . .
ASSOCIATION OF TENDON XANTHOMAS WITH CAROTID ATHEROSCLEROSIS IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA
Authors: Constantina Masoura, Christos Pitsavos, Konstantinos Aznaouridis, Skoumas Ioannis, Charalambos Vlachopoulos, Vassiliki Metaxa, Themistoclis Psarros
Journal: Journal of the American College of Cardiology (2010)
Evidence-Based Nutritional Recommendations for the Treatment and Prevention of Diabetes and Related Complications
Authors: Jim Mann, Kjeld Hermansen, Bengt Vessby, Monika Toeller
Journal: Diabetes Care (2002)

We read with interest the revised 2002 Clinical Practice Recommendations as they relate to nutrition therapy for diabetes (1) as well as the associated Technical Review (2). We would strongly endorse the need to individualize this component of treatment because advice is indeed necessary regarding other aspects of lifestyle, oral hypoglycemic agents, and insulin. However, we question some of the recommendations regarding dietary carbohydrates.

The need for evidence-based guidelines in all aspects of medical management is universally recognized. Unfortunately, with regard to nutritional recommendations, there are no randomized-controlled clinical trials with morbidity and mortality as end points. These are regarded as the ultimate type of evidence on which to make recommendations. We therefore have to use less conclusive approaches to study, including several different epidemiological methods and studies of dietary manipulations on surrogate end points known to be related to morbidity and mortality. This inevitably leads to subjective interpretation regarding the quality of studies because it is clearly inappropriate to simply count the numbers of investigations pointing in one direction or another. Furthermore, there is need to determine the emphasis that should be given to one type of evidence compared with another. …
AAV8 Induces Tolerance in Murine Muscle as a Result of Poor APC Transduction, T Cell Exhaustion, and Minimal MHCI Upregulation on Target Cells
Authors: Lauren E Mays, Lili Wang, Jianping Lin, Peter Bell, Alison Crawford, E John Wherry, James M Wilson
Journal: Molecular Therapy (2013)

Following gene transfer of adeno-associated virus 2/8 (AAV2/8) to the muscle, C57BL/6 mice show long-term expression of a nuclear-targeted LacZ (nLacZ) transgene with minimal immune activation. Here, we show that pre-exposure to AAV2/8 can also induce tolerance to the more immunogenic AAV2/rh32.33 vector, preventing otherwise robust T-cell activation and allowing stable transgene expression. Depletion and adoptive transfer studies showed that a suppressive factor was not sufficient to account for AAV2/8-induced tolerance, whereas further characterization of the T-cell population showed upregulation of the exhaustion markers PD1, 2B4, and LAG3. Furthermore, systemic administration of Toll-like receptor (TLR) ligands at the time of AAV2/rh32.33-administration broke AAV2/8-induced tolerance, restoring T-cell activation and β-gal clearance. As such, AAV2/8 transduction appears to lack the inflammatory signals necessary to prime a functional cytotoxic T-cell response. Inadequate T-cell priming could be explained upstream by AAV2/8's poor transduction and activation of antigen-presenting cells (APCs). Immunohistochemical analysis indicates that AAV2/8 transduction also fails to upregulate major histocompatibility complex class I (MHCI) expression on the surface of myocytes, rendering transduced cells poor targets for T-cell-mediated destruction. Overall, AAV2/8-induced tolerance in the muscle is multifactorial, spanning from poor APC transduction and activation to the subsequent priming of functionally exhausted T-cells, while simultaneously avoiding upregulation of MHCI on potential targets.
A History of Psychiatry: From the Era of the Asylum to the Age of Prozac
Authors: Michael T. McGuire
Journal: JAMA (1997)

The bookstalls are full of books about psychiatry. Some are interesting. Some are dull. And some make the mistake of imagining that political advocacy, pseudoscience, metaphysics, or fanaticism offer a better approach to understanding mental illness than studying the brain. Thus, when an eminent social historian writes a book entitled<i>A History of Psychiatry</i>, one opens the pages expecting a rational, evidence-based, and well-argued look into psychiatry past and present. Edward Shorter, the Hannah Professor in the History of Medicine at the University of Toronto, has not disappointed us. He has used his considerable intellectual and writing talents to develop a nonapologetic revision of psychiatry from the 18th century to the era of Prozac. His story begins by chronicling changes in the asylums of the 18th century which, during the early years of the century, were little more than jails for the insane. With the unchaining of
Audi Alteram Partem.
Authors: H. H. Vinke
Journal: JAMA (1889)

<h3>To the Editor:</h3> —In an editorial in the last issue ofThe Journalwhich I have read with a great deal of interest, you attempt to draw a comparison between the results of the medical and the surgical treatment of acute intestinal obstruction, and you claim that whereas 30 per cent, recover after medical treatment, 68.9 per cent, succumb to surgical treatment. If you will permit me to venture an opinion upon this subject, I would suggest that you are not stating the proposition fairly. You no doubt are aware that only those patients are subjected to surgical treatment who, in spite of the old and classical opium treatment, continue to grow worse; and that operative interference is, as a rule, unfortunately delayed till the patient is greatly exhausted and his physician and friends realize that death is inevitable without the same. As in cases of intestinal obstruction, therefore, medical
Neonatal screening for cystic fibrosis
Authors: N. J Wald, J. K Morris
Journal: BMJ (1998)

cohort study of women included in the Swedish national inpatient register.They compared first hospitalisation rates for connective tissue diseases between 7442 women with implants and 3353 women who had undergone breast reduction surgery over 92 880 person years of observation.No significant increase in risk of connective tissue disease was apparent when rates in the implant group were compared with expected rates in the general population (standardised hospitalisation ratio 1.1; 0.8 to 1.6) or with those in the breast reduction group (1.3; 0.7 to 2.2).Careful attention was paid to validating diagnoses, and the use of admission rather than self reports of disease improves specificity.The results add weight to the conclusion that silicone breast implants are not associated with a meaningful excess risk of connective tissue disease.It is difficult to see how epidemiological studies will shed more light on this vexed issue.Some of those concerned in prolonged legal disputes are clearly unshakeable in their belief that the association exists, and the public reputation of silicone breast implants may have been irrevocably tarnished.
Value of a Grocery Cart and Walker in Identification and Management of Symptomatic Spinal Stenosis in Diabetic Patients Presenting With Peripheral Neuropathy or Claudication
Authors: Stuart M. Goldman
Journal: Diabetes Care (2003)

Lumbar spinal stenosis (SS) may produce symptoms similar to and frequently mistaken for diabetic peripheral neuropathy (DPN). Both axial loading (1), as seen with walking, and spinal extension (2), seen in an erect position, decrease the diameter of both the central spinal canal and lateral recesses. Common extremity symptoms include neurogenic-induced claudication (of the legs) and neurogenic positional pedal neuritis (of the feet) (3), and are frequently reduced by flexion of the spine, facilitated by leaning forward …
Memory B Cells without Somatic Hypermutation Are Generated from Bcl6-Deficient B Cells
Authors: Hirochika Toyama, Seiji Okada, Masahiko Hatano, Yoshimasa Takahashi, Nobue Takeda, Hirohito Ichii, Toshitada Takemori, Yoshikazu Kuroda, Takeshi Tokuhisa
Journal: Immunity (2002)
Mental Symptoms Associated with Head Injury
Authors: E. Mapother
Journal: BMJ (1937)

The prevalence of penicillinase producing Neisseria gonorrhoeae at this hospital increased exponentially from less than 0.5% in 1978 to 6.5% of all isolates in 1982. In January 1983 first line treatment for uncomplicated heterosexual anogenital gonorrhoea was therefore changed from ampicillin and probenecid to spectinomycin. This subsequently cured 95% of cases seen at the Praed Street Clinic. Although there was an initial fall in the monthly isolation rate of penicillinase producing N gonorrhoeae after the introduction of spectinomycin, this was not maintained. The exponential increase in the prevalence of the strain did slow in 1983, rising to only 8.7%. This, however, may have reflected a general decline in the rate of increase of penicillinase producing N gonorrhoeae throughout Britain. The failure to influence the prevalence of penicillinase producing N gonorrhoeae to any great degree may have been due in part to spectinomycin resistance in both penicillinase producing and non-penicillinase-producing N gonorrhoeae. All of the isolates appeared identical, apart from the presence of the 4.4 megadalton plasmid in penicillinase producing N gonorrhoeae, but they could not be linked epidemiologically. Changing treatment in only one of the many venereal diseases clinics in London, where patients have open access to all such clinics, is unlikely to affect the prevalence of penicillinase producing N gonorrhoeae. This has probably been more important than spectinomycin resistance in limiting the effectiveness of spectinomycin in reducing the prevalence of the strain.
Liver Involvement in Early Autosomal-Dominant Polycystic Kidney Disease
Authors: Marie C. Hogan, Kaleab Abebe, Vicente E. Torres, Arlene B. Chapman, Kyongtae T. Bae, Cheng Tao, Hongliang Sun, Ronald D. Perrone, Theodore I. Steinman, William Braun, Franz T. Winklhofer, Dana C. Miskulin, Frederic Rahbari-Oskoui, Godela Brosnahan, Amirali Masoumi, Irina O. Karpov, Susan Spillane, Michael Flessner, Charity G. Moore, Robert W. Schrier
Journal: Clinical Gastroenterology and Hepatology (2014)
ESTIMATION OF LEFT VENTRICULAR CONTRACTILE FUNCTION IN HYPERTENSION BY MYOCARDIAL GLOBAL STRAIN RATE USING NOVEL REAL-TIME THREE-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHY WITH HIGH VOLUME RATE
Authors: Ryota Watanabe, Masanori Kawasaki, Michael Zile, Ryuhei Tanaka, Maki Nagaya, Helene Houle, Hirotaka Miwa, Takashi Yoshizane, Takashi Kato, Takatomo Watanabe, Koji Ono, Masazumi Arai, Toshiyuki Noda, Sachiro Watanabe, Shinya Minatoguchi
Journal: Journal of the American College of Cardiology (2014)
Inhibition of p38 Mitogen-Activated Protein Kinase Decreases Cardiomyocyte Apoptosis and Improves Cardiac Function After Myocardial Ischemia and Reperfusion
Authors: Xin L. Ma, Sanjay Kumar, Feng Gao, Calvert S. Louden, Bernard L. Lopez, Theodore A. Christopher, Chuanlin Wang, John C. Lee, Giora Z. Feuerstein, Tian-Li Yue
Journal: Circulation (1999)

Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in apoptotic cell death. The role of p38 MAPK in myocardial injury caused by ischemia/reperfusion, an extreme stress to the heart, is unknown.Studies were performed with isolated, Langendorff-perfused rabbit hearts. Ischemia alone caused a moderate but transient increase in p38 MAPK activity (3.5-fold increase, P<0.05 versus basal). Ischemia followed by reperfusion further activated p38 MAPK, and the maximal level of activation (6.3-fold, P<0.01) was reached 10 minutes after reperfusion. Administration of SB 203580, a p38 MAPK inhibitor, decreased myocardial apoptosis (14.7+/-3.2% versus 30.6+/-3.5% in vehicle, P<0.01) and improved postischemic cardiac function. The cardioprotective effects of SB 203580 were closely related to its inhibition of p38 MAPK. Administering SB 203580 before ischemia and during reperfusion completely inhibited p38 MAPK activation and exerted the most cardioprotective effects. In contrast, administering SB 203580 10 minutes after reperfusion (a time point when maximal MAPK activation had already been achieved) failed to convey significant cardioprotection. Moreover, inhibition of p38 MAPK attenuated myocardial necrosis after a prolonged reperfusion.These results demonstrate that p38 MAPK plays a pivotal role in the signal transduction pathway mediating postischemic myocardial apoptosis and that inhibiting p38 MAPK may attenuate reperfusion injury.
Edward J. Huth to Retire: The Search Begins for His Successor
Authors: Nicholas E. Davies
Journal: Annals of Internal Medicine (1988)

Editorials15 October 1988Edward J. Huth to Retire: The Search Begins for His SuccessorNicholas E. Davies, MDNicholas E. Davies, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-8-611 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Annals of Internal Medicine has made remarkable progress in its 68-year existence. As judged by such standards as circulation, advertising revenues, and especially the SCI Journal Citation Reports "Impact Factor," it is now the leading specialty medical journal in the English-speaking world. Its leading sister journals—one might say leading competitors in the sense that they do compete for the best internal medicine papers and for advertising—are all general medical journals that are published weekly.Much of the preeminence ofAnnalsmust be attributed to its editor, Edward J. Huth, MD. Continuing the Pincoffs-Elkinton tradition of excellence, Dr. Huth has...Reference1. Clegg H. Some principals and problems of medical editing. Internat Record Med. 1960;173:419-25. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNew Editors for Annals of Internal MedicineNicholas E. Davies, MDA Tribute to Edward Huth, EditorJohn R. Ball, MD, JD 15 October 1988Volume 109, Issue 8Page: 611-611 Issue Published: 15 October 1988 PDF downloadLoading ...
What sort of evidence do we need in primary care?
Authors: Sharon Mickan, Deborah Askew
Journal: BMJ (2006)

General practitioners need evidence from and about the patients they see 

I n this week's BMJ (p 635), Mant and colleagues raise again the question of whether large scale randomised controlled trials provide evidence relevant to primary care.1 In a cross sectional study they question whether the UK national clinical guidelines for stroke are applicable to primary care patients. These guidelines, largely based on the PROGRESS trial,1 recommend a target blood pressure of 140/85 mm Hg, with further lowering beyond this target desirable through use of a thiazide diuretic and an angiotensin converting enzyme inhibitor.2

Mant and colleagues critiqued the applicability of these guidelines to primary care patients by comparing the characteristics of patients in English general practice who had confirmed stroke with participants in the PROGRESS trial. They concluded that these populations were not sufficiently similar to warrant widespread use …
Abstract of original contributions to be presented at the American College of Cardiology 52nd Annual Scientific Session, March 30–April 2, 2003, Chicago, Illinois Angiography and interventional cardiology
Authors: Shinjo Sonoda, Yoshihiro Morino, Junya Ako, Ali Hassan, Mark Reisman, Shing C. Wong, Theodore A. Bass, Alan C. Yeung, Martin B. Leon, Jeffrey W. Moses, Paul G. Yock, Yasuhiro Honda, Peter J. Fitzgerald
Journal: Journal of the American College of Cardiology (2003)