tbuckley/cabot-search huggingface dataset:
Counting Deaths Due to Medical Errors
Authors: Rodney A. Hayward
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patient and Parent Perspectives on Quality of Life during Participation in a Study of Rapid Oral Desensitization with Omalizumab Therapy in Patients with Milk Allergy
Authors: J.S. LeBovidge, S. Haskell, I. Borras, E. Hoyte, D.T. Umetsu, K.C. Nadeau, L.C. Schneider
Journal: Journal of Allergy and Clinical Immunology (2012)
Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study
Authors: Richard A. Larson, Brian J. Druker, Francois Guilhot, Stephen G. O'Brien, Gilles J. Riviere, Tillmann Krahnke, Insa Gathmann, Yanfeng Wang
Journal: Blood (2008)
1099-91 Treatment and outcome of diabetic patients with stable angina and first angiographic diagnosis of coronary artery disease in Germany: Results of the STAR registry
Authors: Anselm K Gitt, Harm Wienbergen, Christina Vogel, Tobias Heer, Karl Siegler, Martin G Gottwik, Jochen Senges
Journal: Journal of the American College of Cardiology (2004)
Abstract A15: Snail upregulation of SPARC leads to increased invasion in models of both early-and late-stage NSCLC
Authors: Jeanette L. Grant, Tonya C. Walser, John D. Minna, Jerry W. Shay, Steven M. Dubinett
Journal: Clinical Cancer Research (2012)

Abstract The zinc-finger protein Snail is upregulated in human non-small cell lung cancer (NSCLC) tissues and is associated with poor patient prognosis. We have shown that Snail upregulation in lung cancer cell lines leads to morphologic changes indicative of epithelial-mesenchymal transition (EMT) in vitro and tumor progression in vivo. Snail overexpression is associated with differential gene expression related to diverse aspects of lung cancer progression. One gene upregulated by Snail in both NSCLC and histologically normal human bronchial epithelial cell lines is secreted protein, acidic and rich in cysteine (SPARC). Expression of SPARC modulates reversible interactions between cells and their extracellular matrix and is known to play an important role in the wound healing process of normal epithelial cells. Its upregulation in several cancer types is associated with increased migration, invasion, and poor patient prognosis. Here, we show that overexpression of Snail leads to increased invasion in a modified Boyden chamber assay in models of both early and late stage NSCLC. Knockdown of SPARC by shRNA leads to a reversal of invasion, indicating that SPARC is at least partially responsible for the effect of Snail on invasion. Computational analysis indicates that Snail does not directly enhance the transcription of SPARC; therefore, we have investigated the indirect mechanism for this relationship. Both ERK1/2 and the chaperone protein HSP27 have emerged as potential components of the pathway. Snail overexpression also leads to activation of ERK1/2, and chemical inhibition of this pathway leads to a decrease in SPARC protein. Snail-overexpressing cell lines show increased transcription of HSP27 mRNA. As Snail has been shown to be overexpressed in the inflammatory microenvironment of premalignancy and in established tumors, SPARC-driven invasion supports both the parallel and linear models of tumor progression. Delineating pathways involved in Snail-dependent and SPARC-mediated tumor progression may yield new targets for lung cancer prevention and treatment.
Maternal Alcohol Consumption and Birth Weight
Authors: Henry L. Rosett
Journal: JAMA (1985)

To the Editor.—  The association between light drinking and low birth weight reported by Mills et al 1 in Maternal Alcohol Consumption and Birth Weight must be cautiously considered. In a cohort of 31,604 pregnancies, the 3% who drank the most included women reporting consumption of one to two drinks per day (2.4%), those reporting three to four drinks per day (0.4%), and those reporting six or more drinks per day (0.1%). Decreased birth weights were observed in offspring of these 3% of the mothers. In light of many other surveys of drinking practices among pregnant women, which have identified 2% to 14% of pregnant women as heavy drinkers, 2 we suggest that the top 3% in this study may have been underreporting their alcohol use. Thus, while there is clearly a higher incidence of low birth weight among offspring of the women in this top 3%, an association between light drinking and reduced birth weight is not demonstrated.
MRI 6/3/93: Terrors where Poe never thought to look
Authors: William R. Davidson
Journal: Annals of Internal Medicine (1995)

Ad Libitum15 September 1995MRI 6/3/93: Terrors where Poe never thought to lookWilliam R. Davidson, Jr., MDWilliam R. Davidson, Jr., MDMilton S. Hershey Medical Center Hershey, PA 17033Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-6-199509150-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Montresor, hot with vengeance, did (for some imagined slight)What doctors unperturbed perform to plumb their patients' plight.You've back pain unremitting, paresthesias, tremor, lame?An MRI is what we need to help us fix the blame.The unsuspecting Fortunato wore a jester's cap.A flask of wine his senses dulled, a shield against the damp.In shroudlike gown, but yet no flask, the patient, too aware,Is laid upon the narrow bier t'endure the magnet's stare.Just 20 minutes now, or ... Author, Article, and Disclosure InformationAffiliations: Milton S. Hershey Medical Center Hershey, PA 17033Corresponding Author: Milton S. Hershey Medical Center, 500 University Drive, Room C5833, PO Box 850, Hershey, PA 17033. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1995Volume 123, Issue 6Page: 427KeywordsDeoxyadenosine monophosphateEngineersFearHeartLower back painSweatWine ePublished: 15 August 2000 Issue Published: 15 September 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Strangulated Inguinal Hernia Simulated by Blood in the Scrotum
Authors: J. C. Uhthoff
Journal: BMJ (1880)

by him.Dr. Schliep (loco cit.) "uses the stomach pumph daily in dilatation, and, if the liquids be very acid, adds bicarbonate of soda to the water; or permanganate of potash, if these liquids show signs of fer- mentation; carbolic acid, when they contain vegetable parasites; boracic acid, as a disinfectant; and tincture of myrrh, in atonic dyspepsia with abundant secretion of mucus".Drs.Clifford Allbutt and E. H1.Jacob of Leeds have obtained good results, which are amongst the earliest reported in this country.A few cases have bcen successfully treated in King's College Ilospital, by D)r.Duffin; in the Birmingham General Hospital, by l)r.Russell; in the Western and Ro)yal Infirm- aries, Glasgow, by Drs.Gairdner and WVood Smith respectively.The stomnach syphon-tube is that which was brought before the Edinburgh meeting of the Association by Dr. hIarvcy of Abcrdeen.
Addition of interleukin 1 (IL1) and IL17 soluble receptors to a tumour necrosis factor alpha soluble receptor more effectively reduces the production of IL6 and macrophage inhibitory protein-3alpha and increases that of collagen in an in vitro model of rheumatoid synoviocyte activation
Authors: G Chevrel
Journal: Annals of the Rheumatic Diseases (2002)

<b>Objectives:</b> To evaluate the usefulness of combination treatment with cytokine inhibitors. <b>Methods:</b> A simplified model was set up to evaluate the effect of tumour necrosis factor α (TNFα) soluble receptors (sTNFR) used alone and in combination with soluble interleukin 1 receptor (sIL1R) and sIL17R on the production of markers of inflammation (IL6), of migration of dendritic cells (macrophage inhibitory protein-3α (MIP-3α)), and of matrix synthesis (C-propeptide of type 1 collagen (P1CP)). Synoviocytes were stimulated with supernatants of activated peripheral blood mononuclear cells (PBMC) from patients with rheumatoid arthritis (RA). Soluble receptors (sR) were preincubated at 1 γg/ml alone or in combination with the supernatants before addition to RA synoviocytes. IL6, MIP-3α, and P1CP production was measured by enzyme linked immunosorbent assay (ELISA) in 48 hour synoviocyte supernatants. <b>Results:</b> IL6 production decreased by 16% with sTNFR alone compared with no sTNFR (p&lt;0.001) and by 41% with the combination of the three sR (p&lt;0.001). MIP-3α production decreased by 77% with sTNFR alone compared with no sTNFR (p&lt;0.001) and by 98% with the combination of the three sR (p&lt;0.001). In the presence of sTNFR alone, P1CP production increased by 25% compared with no sR (p&lt;0.01). The combination of the three sR increased P1CP production by 48% (p&lt;0.01). <b>Conclusion:</b> The effect of sTNFR on IL6, MIP-3α, and P1CP production by RA synoviocytes stimulated by activated PBMC supernatants was further enhanced when combined with sIL1R and sIL17R.
PATHOGENIC STAPHYLOCOCCI —TO TYPE OR NOT TO TYPE
Authors: Valerie Hurst
Journal: JAMA (1962)

Phage typing has now proved to be a useful means for distinguishing different strains of Staphylococcus aureus . With the present prevalence of staphylococcal infections in hospitals, the advisability of phage typing is often debated. In making this decision, one may find it useful to bear certain facts in mind.  Phage typing has no prognostic value for the individual patient because it does not measure virulence. While strains of type 80/81 recently have caused many hospital infections, strains of other types have predominated at other times and in other countries. Any strain of staphylococcus which has produced infection must be regarded as potentially virulent.  Phage typing is solely an epidemiological tool. When applied together with documented clinical observations, it has value in (1) defining possible routes of spread in a circumscribed outbreak of disease, (2) maintaining surveillance of strains responsible for disease in a hospital or community, and (3) assessing distribution
Avoiding injuries caused by pigs
Authors: G Robertson, M Nicholson
Journal: BMJ (1989)

specialised team provides a special seating service for patients referred from a wider area.Our experience has resulted in an acute awareness of many shortfalls of standard issue wheelchairs and, together with the experience of other centres in Scotland, has enabled the Wheelchair Advisory Service, through the auspices of the Central Services Agency who are now responsible for purchasing chairs in Scotland, to address the problems thus identified with a view to improving the overall quality of care.
Diaphragmatic paralysis after herpes zoster.
Authors: J. Brostoff
Journal: BMJ (1966)

BRITISH 1571receiving iron, and neither receiving folic acid.This finding is superficially at variance with that of Chanarin et al. (1965), who found a greater fall of serum folate in late pregnancy among unsupplemented compared with iron-supplemented patients.However, this difference 'was not continued into the postpartum period in their cases, and this was the time at which the serum folate level was measured in the present series.Like Chanarin et al. ( 1965), we have found a higher incidence of megaloblastic anaemia, though different criteria were employed, in the unsupplemented group 1, compared with the iron- supplemented group 2 patients (Table III).The numbers of cases, however, are small. SummaryAntenatal patients have been randomly allocated to five prophylactic treatment groups at their first clinic visit.There- after their haemoglobin level was estimated at each visit, and they were removed from the trial if anaemia developed.In 350 consecutive patients the 2-4 day postpartum fasting serum folate level was measured.It was found that these levels were similar in the non-supplemented group 1 and the iron- supplemented group 2, but significantly raised in the iron plus 100 tig. of folic-acid-supplemented group 3.In the groups
The Secretion of 5-Hydroxytryptamine by a Poorly-differentiated Bronchial Carcinoma
Authors: D. J. Parish, N. Crawford, A. T. Spencer
Journal: Thorax (1964)

The production of serotonin (5-hydroxtryptamine) and certain related metabolites by tumours asso- ciated with the clinical carcinoid syndrome has now been well established.Many of the reported cases have concerned carcinoid tumours of the intestinal tract (Thorson, 1958 ; Macfarlane, Dalgliesh, Dutton, Lennox, Nyhus, and Smith, 1956) but tumours histologically resembling car- cinoids, and also apparently responsible for the carcinoid synidrome or the secretion of serotonin, have been reported from other sites.Of these, the so-called bronchial 'adenomas' are perhaps the commonest (Anlyan, Hargrove, Ruffin, Wallace,
Physical activity limits pulmonary endothelial activation in sickle cell SAD mice
Authors: Emeline Aufradet, Aymeric Douillard, Emmanuelle Charrin, Aymen Romdhani, Genevieve De Souza, Amine Bessaad, Camille Faes, Vanessa Bourgeaux, Erica N. Chirico, Emmanuelle Canet-Soulas, Vincent Pialoux, Cyril Martin
Journal: Blood (2014)
Urinary Albumin Excretion and Glomerular Filtration Rate across the Spectrum of Glucose Abnormalities in Essential Hypertension
Authors: Josep Redon, Francisco Morales-Olivas, Alberto Galgo, Miguel ángel Brito, Javier Mediavilla, Rafael Marín, Pilar Rodríguez, Salvador Tranche, José Vicente Lozano, Claudia Filozof
Journal: Journal of the American Society of Nephrology (2006)

The objective of this study was to assess the relationship between urinary albumin excretion (UAE) and GF across the spectrum of the glucose metabolism abnormalities in a large population of patients with hypertension. The Microaluminuria en Pacientes con Glucemia Basal Alterada (MAGAL) is a multicenter, cross-sectional study that was carried out by 1723 primary care physicians. A total of 6227 patients with essential hypertension (in three groups: [1] normal fasting glucose <100 mg/dl, [2] impaired fasting glucose > or =100 to 126 mg/dl, and [3] type 2 diabetes) were analyzed in this substudy. GFR was estimated by using the Modification of Diet in Renal Disease (MDRD) abbreviated equation. A single first-morning urine albumin/creatinine ratio was measured using Bayer reagent strip Microalbustix, a semiquantitative method. Abnormal UAE was defined as an albumin/creatinine ratio > or =3.4 mg/mmol (equivalent to > or =30 mg/g). The prevalence of abnormal UAE, > or =3.4 mg/mmol, increased across the spectrum of glucose abnormalities: 39.7, 46.2, 48.6, and 65.6% for normoglycemic, low-range, and high-range impaired fasting glucose and diabetes, respectively. UAE was positively related to SBP (P = 0.003) and inversely to GFR (P < 0.001). Renal insufficiency (GFR <60 ml/min per 1.73 m2) was present in 21.8% of the patients, more frequently older patients, women, and those with diabetes. The factors that were related to renal insufficiency were UAE > or =3.4 mg/mmol (odds ratio 1.86; 95% confidence interval 1.60 to 2.17) and diabetes (odds ratio 1.62; 95% confidence interval 1.29 to 2.04). There is a close relationship between abnormal UAE and renal insufficiency in essential hypertension. This is more marked in patients with diabetes and moderate in patients with high-range impaired fasting glucose.
PubMed Central: Government as Publisher?
Authors: Deborah Gesensway
Journal: Annals of Internal Medicine (2000)

Current Clinical Issues21 November 2000PubMed Central: Government as Publisher?Deborah GesenswayDeborah GesenswaySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-10-200011210-00102 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail If some of the country's leading biomedical thinkers have their way, the process of scientific publishing, which has served clinicians and the public extraordinarily well for the past several centuries, will undergo a revolutionary change. In this new system, print journals would no longer control distribution of the results of scientific investigation. Instead, access to all of the world's biomedical literature would be available free of charge to anyone with access to a computer and the Internet.This concept is particularly important because it is not simply some theorists' futurist, millennial predictions. It is already taking shape as PubMed Central, ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySTM publishing meets NIH digital archive: librarian service on the PubMed Central National Advisory CommitteeBiomedical Literature MiningEvaluation of Peer Review in Biomedical PublicationPublishing at the speed of life 21 November 2000Volume 133, Issue 10Page: 841-844KeywordsArchivesCell biologyCell physiologyComputersDatabasesForecastingInternetLibrariesPeer reviewScientists ePublished: 21 November 2000 Issue Published: 21 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
A CASE OF PRECOCIOUS MENSTRUATION.
Authors: M. J. FORD
Journal: JAMA (1904)

<h3>Patient.</h3> —I was recently called to see a child who had swallowed a baby pin and was at once struck with the unusual development of the child. It was two years and four months of age, but had the body and limbs of a much older child. <h3>History.</h3> —The child was born May 13, 1902, and the mother noticed soon after its birth that the external genitals were enlarged. She asked her attendant about it and was told that it was a little swelling, which would soon disappear. The child was fretful and cried practically all the time when awake till it was six months old. Its sleep had never been good, and it was always restless. When six months old the mother noticed that the child was bleeding as if menstruating. The flow became very free and the child sank into its first peaceful sleep. The flow continued for 3 or
Incidence of cancer among Finnish airline cabin attendants, 1967-92
Authors: E. Pukkala, A. Auvinen, G. Wahlberg
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective</b>: To assess whether occupational exposure among commercial airline cabin attendants are associated with risk of cancer. <b>Design</b>: Record linkage study. <b>Setting</b>: Finland. <b>Subjects</b>: 1577 female and 187 male cabin attendants who had worked for the Finnish airline companies. <b>Main outcome measure</b>: Standardised incidence ratio; expected number of cases based on national cancer incidences. <b>Results</b>: A significant excess of breast cancer (standardised incidence ratio 1.87 (95% confidence interval 1.15 to 2.23)) and bone cancer (15.10 (1.82 to 54.40)) was found among female workers. The risk of breast cancer was most prominent 15 years after recruitment. Risks of leukaemia (3.57 (0.43 to 12.9)) and skin melanoma (2.11 (0.43 to 6.15) were not significantly raised. Among men, one lymphoma and one Kaposi9s sarcoma were found (expected number of cases 1.6). <b>Conclusions</b>: Although the lifestyle of cabin attendants is different from that of the reference population—for example, in terms of social status and parity—concentration of the excess risks to primary sites sensitive to radiation suggests that ionising radiation during flights may add to the cancer risk of all flight personnel. Otherwise the lifestyle of cabin attendants did not seem to affect their risks of cancer. Estimates of the effect of reproductive risk factors only partly explained the
A Clinical Lecture ON SOME OF THE COMMONER SYMPTOMS OF CEREBELLAR ABSCESS: Delivered at University College Hospital
Authors: W. Trotter
Journal: BMJ (1908)

MARCH. 14, 1P5 affeotion of the nervous system, and in which there are no special signs, suoh as .mayobtain in some functional cases,,to establiah the diagnosis.The following is a good ilustration of what is meant: *A woman was seen In the out-patient room at the Queen Square Hospltal, with a history from her doctor that there had been two attacks of, pneumonia, one of which had been complicated by pericarditis, and that subse- quently to this she had developed certain choreiform movemnents, with inability to speak.The patient was unable to stand or walk, and was apparently so weak.that she could not even sit up.Severe spasmodic movemenlts affected all of her limbs, together with her neck and trunk.This was clearly not the kind of case in which I could look for assitance from one or other of the signs of organic disease to which I have called your attention, and physical examination did not reveal any particular signs that may exist in hysterla.My suspicion as to the real nature of the case was, however, aroused when I tried to lnduee the woman to speak, for, instead of the articulatory difficulty so characteristic of chorea, with -the rolling about of the tongue and other unsuccessful efforts at articulation, the patient made a grimace that did not recall to my mind anything that I expected in chorea, and spoke in a whisper without any of the articulatory defects for which I was prepared.With this clue to the real nature ol her condition, I was next able to persuade her to control the movements of one or other limb, so as to enable me to test her tendon jerks and plantar reflexes, and with isolation and strong faradism, com-