Mesantoin Lymphadenopathy Morphologically Simulating Hodgkin's Disease
Authors: A. P. DOYLE
Journal: Annals of Internal Medicine (1963)

Case Studies1 September 1963Mesantoin Lymphadenopathy Morphologically Simulating Hodgkin's DiseaseA. P. DOYLE, M.D., H. R. HELLSTROM, M.D.A. P. DOYLE, M.D.Search for more papers by this author, H. R. HELLSTROM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-363 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMore than 80 examples of lymphadenopathy occurring after anticonvulsant therapy have been recorded. Most of the hydantoin derivatives have been implicated as being responsible for this effect, mephenytoin, 3-methyl-5, 5-phenylethyl hydantoin (Mesantoin®) being the chief offender. In addition, fatal polyarteritis nodosa (1), aplastic anemia (2), and systemic lupus erythematosus (3) have been observed after anticonvulsant therapy.The lymphadenopathy has a fairly characteristic clinical course that begins one week to several months after the offending drug therapy has been started. The involved nodes are often tender; they may be several centimeters in diameter and generally regress within a few weeks after...References1. FRANKELROTHERMICH ALNO: Polyarteritis nodosa: review together with report of case due to hydantoin sensitization treated with Cortisone. Ohio Med. J. 47: 1013, 1951. MedlineGoogle Scholar2. HARRISONJOHNSONAYER FFRDD: Fatal aplastic anemia following use of Tridione and a hydantoin. JAMA 132: 11, 1946. CrossrefMedlineGoogle Scholar3. BENTONTYNESREGISTERALFORDHOLLEY JWBHBCHL: Systemic lupus erythematosus occurring during anticonvulsive drug therapy. JAMA 180: 115, 1962. CrossrefGoogle Scholar4. SNAPPERMARKSSCHWARTZHOLLANDER IDLL: Hemolytic anemia secondary to Mesantoin. Ann. Intern. Med. 39: 619, 1953. LinkGoogle Scholar5. WUANICHIRINOSGOMEZ HEOL: Hemolytic anemia in a patient treated by Mesantoin. Acta Med. Venez. 7: 93 1959, Abstract cited in Blood 15: 567, 1960. Google Scholar6. ROSENFELDSWILLERSHENOYMORRISON SAIYMAN: Syndrome simulating lymphosarcoma induced by diphenylhydantoin sodium. JAMA 176: 491, 1961. CrossrefMedlineGoogle Scholar7. SALTZSTEINACKERMAN SLLV: Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically and pathologically malignant lymphomas. Cancer 12: 164, 1959. CrossrefMedlineGoogle Scholar8. MELLERRESCH RLJA: Convulsive dis-orders in adults. Postgrad. Med. 6: 452, 1949. CrossrefMedlineGoogle Scholar9. JACKSONPARKER HF: Hodgkin's Disease and Allied Disorders. Oxford University Press, New York, 1947. Google Scholar10. Lymphoma or drug reaction occurring during hydantoin therapy for epilepsy. Clinicopathologic Conference. Amer. J. Med. 32: 286, 1962. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. P. DOYLE, M.D.; H. R. HELLSTROM, M.D.Affiliations: Pittsburgh, PennsylvaniaFrom the Medical and Laboratory Services, Veterans Administration Hospital, Pittsburgh, Pa.Requests for reprints should be addressed to A. P. Doyle, M.D., Veterans Administration Hospital, University Drive, Pittsburgh, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byApplication of a Prediction Rule to Select which Patients Presenting with Lymphadenopathy Should Undergo a Lymph Node BiopsyPathology of Infectious MononucleosisAspiration biopsy cytology of lymph nodes in malignant lymphomaAppraisal of aspiration cytology in management of Hodgkin's diseaseAn “Abnormal” lymphoid proliferation simulating Hodgkin's disease in a burn patientA pseudolymphomatous reaction in soft tissue associated with phenytoin sodium.Classification of LymphomasAdverse Hematologic Effects of DrugsDRUG‐ASSOCIATED LYMPHADENOPATHIES WITH SPECIAL REFERENCE TO THE REED–STERNBERG CELLMALIGNANT LYMPHOGRANULOMATOSIS AND ANTICONVULSANT THERAPYObservation of cells resembling sternberg-reed cells in conditions other than Hodgkin's diseaseHydantoin-Induced Pseudo-PseudolymphomaRICHARD A. GAMS, JOSEPH A. NEAL, FRED G. CONRADHydantoin lymphadenopathyGENERALIZED LYMPHADENOPATHY AS A DRUG REACTION TO HYDANTOIN 1 September 1963Volume 59, Issue 3Page: 363-368KeywordsAnticonvulsantsAplastic anemiaDrug therapyGranulomasHemolytic anemiaHodgkin lymphomaLupus erythematosusResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1963 PDF downloadLoading ...