tbuckley/cabot-search huggingface dataset:
Enuresis as a Disorder of Development
Authors: R. F. Barbour, E. M. Borland, M. M. Boyd, A. Miller, T. E. Oppe
Journal: BMJ (1963)

From the Bristol Royal Hospital for Sick ChildrenThe concept of enuresis as a primary delay in development of bladder control is not new (Denny-Brown and Robertson, 1933), but much effort has been expended in order to find other physical or emotional causes for this symptom.Bakwin (1961) has pointed out the unsatisfactory nature of the evidence for such causes and has re-emphasized the fact that enuresis tends to disappear with increasing age and has a striking familial incidence.We have not found in the literature an investigation attempting to make a comprehensive assessment of a series of enuretic children which also includes a follow-up study.The study reported here provides evidence regarding the effects of maturation in a series of comprehensively investigated children. Material and MethodsIn a 12-months period during 1951-2 children with enuresis attending the Bristol Royal Hospital for Sick Children were, by arrangement with the consultants concerned, referred to one of us (M.M. B.) for investigation.Preliminary selection of the cases had been made by the family doctor or local authority medical officer; but once referred to the medical, psychological, or urological clinics they were put consecutively into the study.Cases were accepted only if bed-wetting was the major complaint and if the patients had attained the age of 5 years.A total of 111 cases entered the study, and the initial assessment was designed to be comprehensive.A full medical, psychological, and social history was obtained by M. M. B., who also performed the physical examination and cystometry.Psychological assessment included not only the history from the parents but also observations on the child's behaviour and personality in the ward, and a school report was obtained.Intelligence-testing and electro- encephalography were done by the specialist departments.
Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts
Authors: W Yasmin
Journal: Cardiovascular Research (1997)

Objective: The acute release of radicals upon reperfusion following myocardial ischemia may include both nitric oxide (NO) and superoxide anion (O2−⋅). The generation of peroxynitrite (ONOO−) from these radicals may contribute to ischemia-reperfusion injury. Our objective was to measure the generation of ONOO− during reperfusion of isolated hearts subjected to ischemia and to determine the effects of inhibition of NO synthase with NG-monomethyl-l-arginine (l-NMMA), or supplementation of NO with S-nitroso-N-acetyl-d,l-penicillamine (SNAP), on ONOO− generation and on the recovery of mechanical function. Methods and Results: Isolated rat hearts were perfused at constant pressure with Krebs' buffer containing l-tyrosine, which reacts with ONOO− to form dityrosine, a fluorescent product. Dityrosine was detected in the coronary effluent of hearts infused with synthetic ONOO−. In hearts subjected to 20 min of global, no-flow ischemia there was a marked rise in endogenous ONOO− formation which peaked at 30 s of reperfusion. Formation of ONOO− was dependent upon synthesis of both NO and O2−⋅, as dityrosine release was abolished by l-NMMA or superoxide dismutase, respectively. l-NMMA caused a concentration-dependent improvement in the recovery of mechanical function during reperfusion. Infusion of SNAP also abolished dityrosine release at reperfusion and improved the recovery of post-ischemic function. Conclusions: Our results show for the first time that reperfusion of the ischemic heart causes the acute production of ONOO−. Inhibiting the biosynthesis of ONOO− with l-NMMA or antagonizing its oxidant actions with SNAP are possible strategies to protect the heart from ischemia-reperfusion injury.
Disruptive insights in psychiatry: transforming a clinical discipline
Authors: Thomas R. Insel
Journal: Journal of Clinical Investigation (2009)

Mental disorders such as schizophrenia, bipolar illness, and depression have become the predominant chronic diseases of young people, accounting for approximately 40% of the medical burden for people aged 15-44 in the United States and Canada. Research is transforming our understanding of these disorders, as exemplified in the articles in this Review Series. Important, "disruptive" insights into pathophysiology are emerging from studies addressing these illnesses as brain disorders, developmental disorders, and complex genetic disorders--rather than only as psychological conflicts or chemical imbalances, as they were considered in the past. Current medications are not sufficient for most patients. A new and deep understanding of the pathophysiology of these disabling disorders is our best hope for a new generation of treatments that will help patients to recover.
THALLIUM REDISTRIBUTION IN SERIAL STUDIES OF THE MYOCARDIUM
Authors: Thomas D. Kay, Paul V. Celio, Gwynne K. Neufeld, David L. Johnson, David Romo, Mary E. Thompson, Sandy J. Riahi, George M. McGranahan
Journal: Clinical Nuclear Medicine (1982)

Kay, Thomas D.; Johnson, David L.; Romo, David; Thompson, Mary E.; Riahi, Sandy J.; Neufeld, Gwynne K.; McGranahan, George M. Jr. Author Information
FIBROELASTIC DEFICIENCY VERSUS BARLOW'S DISEASE: DIFFERENCES IN MITRAL ANNULAR DYNAMICS BY 3-DIMENSIONAL ECHOCARDIOGRAPHY
Authors: Marie-Annick Clavel, Francesca Mantovani, Ori Vatury, Rakesh Suri, Sunil Mankad, Maurice Sarano
Journal: Journal of the American College of Cardiology (2014)
The Clinical Examination An Agenda to Make It More Rational
Authors: David L. Simel
Journal: JAMA (1997)

<i>JAMA</i>introduced The Rational Clinical Examination series in 1992. The founder of the series, David Sackett, writing with one of us<sup>1</sup>(D.R.), observed that the history and physical examination (together, the clinical examination) frequently supplied all that was needed for a diagnosis, permitted physicians to rule out diagnostic hypotheses, could identify patients at early stages of their diseases, and played an important role in developing rapport with the patient. See also p 564. Sackett and Rennie noted that though facts gleaned from the clinical examination were like laboratory tests in that they had measurable sensitivities, specificities, and predictive powers, investigation of the precision and accuracy of the clinical examination had lagged behind that of more expensive (and perhaps less therapeutic) laboratory tests. They suggested this was because such investigation was arduous and not easily undertaken by those taught to rely on the laboratory; because the clinical diagnosis rarely resides
Simulation in surgical training.
Authors: I M MacIntyre, A Munro
Journal: BMJ (1990)

antidepressants, there are some pointers in that direction.The report of some differences between individuals who respond to cognitive therapy and those who respond to drug treatment and the report of an additive effect between drugs and interpersonal therapy make it reasonable to try psychological treatment in such cases when there are relevant problems for the therapists to work on.Neither form of psychological treatment has been shown convincingly to reduce the relapse rate below that in patients receiving maintenance antidepressants, but there are individual patients in whom relapse seems to be closely related to cognitive factors or interpersonal problems, and in these cases psychological treatment can be tried when other measures have failed.Although the findings of this large American trial do not support a stronger endorsement of these specific techniques of psychotherapy for depressive disorders, its results are of great interest.Our understanding of depressive disorders would be greatly increased if we knew how specific psychological therapy in some moderately depressed patients may bring about changes comparable with those of drug treatment.The results of further investigations, inclu.ding the remaining results of the American study, should help to answer this important question.
Postmenopausal Estrogen Replacement and Breast Cancer
Authors: Elizabeth Barrett-Connor
Journal: New England Journal of Medicine (1989)

AN epidemiologic study in this issue of the Journal 1 could change the way we think about postmenopausal hormone replacement. In the report, 23,244 Swedish women identified from prescription records for the noncontraceptive use of estrogen were followed for an average of six years, and their risk of breast cancer was compared with that of other women from the same geographic area. Cases of breast cancer in the population were identified from a cancer registry. In the combined analysis of all women following all hormone-replacement regimens, estrogen use was not associated with an increased risk of breast cancer. Nevertheless, at least . . .
Modern Application of Tracheostomy
Authors: V. Lambert
Journal: BMJ (1965)

Alpine skiing accidents admitted to the Trondheim Regional and University Hospital during one year were recorded. Of the 339 injured, 67 per cent were male and 33 per cent were female. Eighty-seven per cent were outpatients, and 13 per cent were hospitalized. Falling accidents (67 per cent), followed by collision accidents (17 per cent), were the most common cause of injury. The injuries in the lower extremities were caused by falling and the head injuries were mostly caused by collisions. Knee ligament strains were the most common injuries, and 17 per cent of these were hospitalized and required operative treatment. Of the minor knee strains, all 44 per cent were not fully recovered after two and a half years. Seventeen patients sustained tibial fractures, eleven of them spiral fractures and six transverse fractures. The patients with spiral fractures were younger than the patients with transverse fractures. Head injuries were the most severe injuries, with eleven concussions and two epidural haematomas.
The Neurobiology of Addiction: Implications for Voluntary Control of Behavior
Authors: Steven E. Hyman
Journal: The American Journal of Bioethics (2007)

Abstract There continues to be a debate on whether addiction is best understood as a brain disease or a moral condition. This debate, which may influence both the stigma attached to addiction and access to treatment, is often motivated by the question of whether and to what extent we can justly hold addicted individuals responsible for their actions. In fact, there is substantial evidence for a disease model, but the disease model per se does not resolve the question of voluntary control. Recent research at the intersection of neuroscience and psychology suggests that addicted individuals have substantial impairments in cognitive control of behavior, but this “loss of control” is not complete or simple. Possible mechanisms and implications are briefly reviewed.
Bone Agent and Radiogallium Deposition Around Infiltrated Calcium Gluconate
Authors: MOZAFAREDDIN K. KARIMEDDINI, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1993)

Intravenous administration of calcium gluconate partially infiltrated the hand of a neonate. Because of subsequent redness and swelling, bone and radiogallium studies were performed. Both sets of images showed uptake in the hand crossing the wrist; there was no radiogallium excess on subtracted views. A radiograph showed calcium deposition in the hand, likely accounting for uptake of the imaging agents. The redness in the hand gradually decreased.
Breast Carcinoma Fortuitously Discovered on Myocardial Perfusion Imaging
Authors: LEONIE GORDON, BRIAN GORDON
Journal: Clinical Nuclear Medicine (1996)

A 70-year-old woman had acute chest pain suggestive of angina. Myocardial perfusion scan with Tc-99m sestamibi revealed a large area of increased activity in the left breast. No perfusion defects were noted in the heart. Mammogram obtained 1 week later confirmed a large irregular left breast mass. Operative findings confirmed an infiltrating ductal carcinoma of the left breast.
Ballston Springs, N. Y. as a Resort for Invalids.
Authors: T. D. Crothers
Journal: JAMA (1897)

Hartford, Conn., Oct. 23, 1897. <h3>To the Editor:</h3> —In answer to some inquiries, I would say that the famous old watering place of Ballston Springs, New York, is practically an ideal place for nervous and dyspeptic persons who need a change of surroundings, with quiet, and nature's great remedies, mineral waters. Half a century ago this was the most prominent mineral springs resort in America. Saratoga, four miles north, was a mere hamlet. Now Saratoga has become a great center of hotels, sanitariums and springs, and Ballston is a quiet, dreamy suburban village. Down in a valley protected from the high winds, in the dry bracing air of the Adirondack snow belt, free from fogs and sleet storms, it has many attractions as a residence for invalids. To many persons the invalid atmosphere of sanitariums and the unrest and excitement of hotels are depressing and injurious. Whereas the geniality and
What Is Psychoanalytic Therapy?
Authors: Günter Ammon
Journal: Psychotherapy and Psychosomatics (1974)

Research Articles| February 12 2010 What Is Psychoanalytic Therapy? Subject Area: Psychiatry and Psychology Günter Ammon Günter Ammon Lehr- und Forschungsinstitut für Dynamische Psychiatrie und Gruppendynamik der Deutschen Akademie für Psychoanalyse, Berlin Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1974) 24 (4-6): 355–358. https://doi.org/10.1159/000286760 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Günter Ammon; What Is Psychoanalytic Therapy?. Psychother Psychosom 31 December 1974; 24 (4-6): 355–358. https://doi.org/10.1159/000286760 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1974Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Comparison of hepatic elimination of different forms of cholecystokinin in dogs. Bioassay and radioimmunoassay comparisons of cholecystokinin-8-sulfate and -33-sulfate.
Authors: T Sakamoto, M Fujimura, J Newman, X G Zhu, G H Greeley, J C Thompson
Journal: Journal of Clinical Investigation (1985)

The influence of hepatic transit on the ability of exogenous cholecystokinin-8-sulfate and -33-sulfate (CCK-8 and CCK-33, respectively) to stimulate gallbladder contraction and exocrine pancreatic secretion, as well as on the peripheral plasma concentration of each agent, was evaluated in five conscious dogs with pancreatic and gallbladder fistulas and complete portacaval transposition. The gallbladder pressure increments after portal administration of CCK-8 (0.125, 0.25, 0.50, and 1.0 microgram/kg per h for 5 min) were diminished by 36, 45, 39 and 25%, respectively, in comparison with those obtained with systemic administration of identical doses of CCK-8 (P less than 0.05). In a subsequent experiment, the integrated pancreatic juice volume, bicarbonate, and protein secretion were diminished by 22, 32, and 48%, respectively, during a 30-min infusion of CCK-8 (0.10 micrograms/kg per h) into the portal venous system, in comparison with the results obtained with systemic administration of CCK-8 (P less than 0.05). In contrast, the gallbladder pressure and pancreatic exocrine secretory responses to portal administration of CCK-33 did not differ significantly (P greater than 0.05) from the results obtained with systemic administration of CCK-33. Radioimmunoassay for CCK-8 in plasma showed that the integrated CCK-8 value during portal administration was significantly lower (P less than 0.05) than it was during systemic administration. The results for CCK-33, however, did not vary, whether it was given by a systemic or portal route (P greater than 0.05). Thus, the present study demonstrates that CCK-8 is partially inactivated by the liver whereas CCK-33 is not, which suggests that CCK-3 in the circulation may play a significant role in the physiologic regulation of the gallbladder and exocrine pancreas.
Hepatitis C Virus Antibodies in Parasitic Infections
Authors: Antonio Aceti
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 October 1990Hepatitis C Virus Antibodies in Parasitic InfectionsAntonio Aceti, MD, Gloria Taliani, MDAntonio Aceti, MDSearch for more papers by this author, Gloria Taliani, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-7-560_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The detection of antibodies to hepatitis C virus (HCV) using a recombinant-based immunoassay in patients who did not have risk factors for infection or evidence of liver disease has raised doubts about the test's specificity (1).We recently looked for antibodies to HCV (anti-HCV) in sera specimens from 76 patients with a parasitic infection (49 with surgically proved hydatidosis and 27 with parasitologically diagnosed urinary schistosomiasis), none of whom had a history of blood contacts. Antibody to HCV was tested for using an enzyme-linked immunosorbent assay (ELISA) (Ortho Diagnostic Systems, Raritan, New Jersey). The test was carried...References1. Hepatitis C virus upstanding [Editorial]. Lancet. 1990;1:1431-2. Google Scholar2. PiniPastoreValesini CRG. Circulating immune complexes in sera of patients infected with Echinococcus granulosus. Clin Exp Immunol. 1983;51:572-8. MedlineGoogle Scholar3. FeldmeierRedekerDaffallaKnobloch HKAJ. Specific IgE antibodies and IgE containing circulating immune complexes in human schistosomiasis. Bull Soc Pathol Exot Filiales. 1983;76:571-8. MedlineGoogle Scholar4. McFarlaneTolleyMajor IPG. Development of an enzyme- linked limmunosorbent assay (ELISA) for antibodies against the liver-specific membrane lipoprotein (LSP). J Immunol Methods. 1983;64: 215-25. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Antonio Aceti, MD; Gloria Taliani, MDAffiliations: Institute for Tropical and Infectious Diseases "La Sapienza" University 00161 Rome Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySeroreactivity and Genomic Amplification Profile of Hepatitis C Virus From Patients With Chronic Liver Disease in IndiaHepatitis C virus antibody in SwazilandImproved detection of hepatitis c virus antibodies in high-risk populationsNon-A, Non-B Hepatitis in Dialysis Patients: Diagnosis, Prevention and Treatment 1 October 1990Volume 113, Issue 7Page: 560-560KeywordsAntibodiesEnzyme linked immunosorbent assayHepatitis C virusImmunoassaysInfectious disease immunologyLiver diseasesMedical risk factorsParasitic diseasesSchistosomiasisSpecificity ePublished: 1 December 2008 Issue Published: 1 October 1990 PDF downloadLoading ...
Pseudotumor Acute Gastric Ulcer in a Child
Authors: Jafar Daryabeigi
Journal: JAMA (1977)

ACUTE gastric ulcer in children is often associated with burns, cerebral disease, stress of different origins, and steroid therapy. Chronic gastric ulcer occurs rarely in childhood.1-3The ratio of gastric to duodenal ulcer is about 1:7 in children and adolescents, as compared with 1:3 in adults.4Most gastric ulcers in children are located in the pyloric region.  The roentgenographic features of the ulcer niche—the Hampton line, the ulcer collar, and the ulcer mound— are well known. The inflammatory exudate and edema surrounding a benign gastric ulcer may prevent the niche from projecting beyond the contour of the stomach, thereby simulating an ulcerated gastric neoplasm. The following represents such a case.  Report of a Case  A 2 1/2-year-old girl was admitted to Children's Hospital Medical Center with hematemesis. The child had fallen off a coffee table two days prior to admission, and following this episode she complained of abdominal
THE ESSENTIALS OP SANATORIUM TREATMENT OF TUBERCULOUS GRAVIDAE AND PUERPERAE AND THEIR CHILDREN
Authors: CHARLES S. BACON
Journal: JAMA (1913)

There are about 32,000 tuberculous women pregnant every year in the United States. Between 44,000 and 48,000 women of child-bearing age die of tuberculosis every year. Probably one-fourth of them are puerperae or have passed through pregnancy during the year, or, in other words, the gravidae and puerperae furnish onefourth of all deaths from tuberculosis of women of childbearing age. From this it also follows that about onethird of the pregnant tuberculous women die within a year of their labor. Of 10,000 children under 5 years of age who die of tuberculosis every year, three-fourths are born of tuberculous mothers. These data show a part but not all of the bearing of pregnancy on the tuberculosis problem. Besides the increased loss of life among the tuberculous due to pregnancy, there is increase of infection both among the attendants, relatives and associates of the mothers and among the children. The gravidae