tbuckley/cabot-search huggingface dataset:
THE EFFECT OF IODINE BY MOUTH ON THE REACTION TO INTRAVENOUS INJECTIONS OF THYROXIN
Authors: Cyrus C. Sturgis, Salvador Zubiran, Guy W. Wells, Theodore Badger
Journal: Journal of Clinical Investigation (1926)

Repeated observations within recent years have shown that the oral administration of iodine will usually be followed by a striking reduction in the basal metabolism in patients with exophthalmic goiter.A histologic study of the thyroid glands which have been removed from these patients gives evidence that definite involutional changes follow the use of iodine which indicate an anatomic regression toward a normal or colloid resting state (1).It has, therefore, been assumed on very good evidence that the anatomic alteration of the gland, in part, at least, explains the reduction in the basal metabolism and the associated improvement in the patient's condition.Another
Decreased peripheral blood CD19+ B-cell apoptosis, activation of nuclear factor-kappaB and immunoglobulin gene heavy chain (IgH) rearrangement in hepatitis C virus (HCV) infection: mechanisms for lymphomagenesis?
Authors: Alajos Par, Laszlo Szereday, Beata Gasztonyi, Katalin Kiss, Laszlo Kereskai, Arpad Szomor, Gabriella Par, Jozsef Szeberenyi, Laszlo Pajor, Julia Szekeres-Bartho, Geza Hegedus, Gyula Mozsik
Journal: Journal of Hepatology (2002)
TREATMENT OF FRACTURES OF THE HEAD AND NECK OF THE RADIUS
Authors: J. ALBERT KEY
Journal: JAMA (1931)

In spite of the many papers that have been published on fractures of the upper end of the radius during the past few years, there is at present considerable disagreement even among well qualified bone and joint surgeons as to the proper procedure to be adopted in any given type of lesion. In this paper I shall classify the various fractures encountered in the head and neck of the radius and outline the treatment which I believe should be instituted in each type. One reason that there is so much disagreement in regard to the treatment is that many surgeons are inclined to judge their results by the amount of flexion and extension at the elbow and to ignore the facts that rotation of the forearm may be limited or painful or both, that the arm may be weaker than normal, or that the elbow may be subject to periods
Notes on the Permanent Subcutaneous Method of Wiring the Patella for Fresh Transverse Fracture
Authors: A. E. Barker
Journal: BMJ (1896)

state of calcareous degeneration in the opened up parametrium.I stuffed a large sponige inlto the capsule, sewed its edges together, and as on witlh- drawin!g the sponlge I found that the oozing had ceased I tied the sutures anld di( not introduce a drainage tube.Tle capsule fell to the bottom of tle pelvis.Conivaleseence was rapid.The tumour was a small cyst of the ovary bearinlg soine secon-idary cysts.The left appendages were lhealtlhy.Tlh pain was due in this case to the pressure of the tense cyst against its capsule, wlichl is muchl less yielding tllan the layers of the mesosalpinx.Its tenseiness allowed of diagnosis.In the preceding case, No. iv, the tliin-walled parovariani cyst lhad burrowed downward, Just as the ovarian cyst lhad in this case, No. v, but in iv there was no paini and the fornix seemiied free.The cyst wats ratlher flaccid, lhence not so easy to detect by touclh as in v, nor so likely to be painful.I suspect that it is easier for a parovarian cyst developed between the layers of the mesosalpinx to burrow lower in the broad ligament than for a true ovarian cyst to push itself downwards.CASE VI presented a great peculiarity.The patient was a domestic servant, aged 25, and slingle.A small cyst filled tlhe lower part of the abdomen and intestine lay in front; the fundus of the uterus could be felt in the right groin, its cavity measured 32 iinches, the cervix lying high.No part of the cyst came down into the pelvis.I operated on May ist, I895, assisted by Dr. Hubert Roberts.On tapping a pint and 6 ounces of ovarian fluid escaped.The surface of the tumour was white.On inspecting the tapping hole two distinct layers could be seen, as though there were a true capsule.I placed my hand down behind the supposed capsule and pushed out the eintire cyst, witlh a niormal pedicle.the mesosalpinx anid the ovarian ligament running on to the " capsule."There were no adlhesions, and the opposite (riglht) ovary was healtly.Convalescence was uninterrupted.The " capsule " was simply the ovary itself (Fig. 7) distended by the cyst within its substance.The true cyst wall was connected with the ovarian capsule by very loose connective tissue.Had the union been close and firm, that would have been the usual condition in ovarian cystoma, and no two separate layers would have been seen on inspecting the trocar wouind.On the otlher hand, had the capsule of ovarian tissue been adherent to pelvic structures, the cyst might have been deliberately enucleated from the ovary itself; tele appearance after enucleation would tlleni have been puzzling.
A piece of my mind. Mothers
Authors: M. D. Karr
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gas exchange response to intravenous aminophylline in patients with a severe exacerbation of asthma
Authors: JM Montserrat, JA Barbera, C Viegas, J Roca, R Rodriguez-Roisin
Journal: European Respiratory Journal (1995)

In patients with acute exacerbations of asthma, the intravenous administration of bronchodilators, such as salbutamol, entails the potential risk of worsening pulmonary gas exchange, despite an amelioration of airflow obstruction. The present study was designed to investigate the effect of intravenous aminophylline on pulmonary gas exchange in patients hospitalized with a severe exacerbation of asthma. We studied 12 patients (aged 41 +/- 13 yrs) admitted to the hospital because of an exacerbation of asthma. The study was of a randomized, double-blind, placebo-controlled design. Six patients were treated with intravenous aminophylline and six received placebo, in addition to standard treatment with inhaled salbutamol and intravenous corticosteroids. Forced spirometry, respiratory gas exchange, ventilation-perfusion relationships assessed with the multiple inert gas elimination technique, and systemic haemodynamics were measured at baseline and 60 min after treatment started. In the aminophylline-treated group, mean theophylline plasma levels increased to 15.2 +/- 3.6 micrograms.ml-1, forced expiratory volume (FEV1) increased by 17 +/- 12%, and forced vital capacity (FVC) by 16 +/- 10%. The mean changes in FEV1 and FVC in the aminophylline-treated group were significantly higher than in the placebo-treated group. Likewise, minute ventilation increased by 23 +/- 14% and arterial carbon dioxide tension (PaCO2) decreased by 0.4 +/- 0.3 kPa (3 +/- 2 mmHg) during aminophylline infusion. No significant changes in arterial oxygen tension (PaO2) or in ventilation-perfusion distributions were shown in aminophylline-treated patients.(ABSTRACT TRUNCATED AT 250 WORDS)
The Human Immunodeficiency Virus Type 1 Accessory Protein Vpu Induces Apoptosis by Suppressing the Nuclear Factor κB–dependent Expression of Antiapoptotic Factors
Authors: Hirofumi Akari, Stephan Bour, Sandra Kao, Akio Adachi, Klaus Strebel
Journal: The Journal of Experimental Medicine (2001)

Human immunodeficiency virus (HIV) type 1 Vpu is an integral membrane protein with a unique affinity for βTrCP (TrCP), a key member of the SkpI-Cullin-F-box E3 ubiquitin ligase complex that is involved in the regulated degradation of cellular proteins, including IκB. Remarkably, Vpu is resistant to TrCP-mediated degradation and competitively inhibits TrCP-dependent degradation of IκB, resulting in the suppression of nuclear factor (NF)-κB activity in Vpu-expressing cells. We now report that Vpu, through its interaction with TrCP, potently contributes to the induction of apoptosis in HIV-infected T cells. Vpu-induced apoptosis is specific and independent of other viral proteins. Mutation of a TrCP-binding motif in Vpu abolishes its apoptogenic property, demonstrating a close correlation between this property of Vpu and its ability to inhibit NF-κB activity. The involvement of NF-κB in Vpu-induced apoptosis is further supported by the finding that the levels of antiapoptotic factors Bcl-xL, A1/Bfl-1, and TNF receptor-associated factor (TRAF)1, all of which are expressed in an NF-κB–dependent manner, are reduced and, at the same time, levels of active caspase-3 are elevated. Thus, Vpu induces apoptosis through activation of the caspase pathway by way of inhibiting the NF-κB–dependent expression of antiapoptotic genes.
Getting Beyond the Ganglion Cell
Authors: Ari J. Green
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Sex workers to pay the price: Prostitution strategy is a missed opportunity
Authors: Sam Ramaiah
Journal: BMJ (2006)

EDITOR—The safety of sex workers in prostitution as well as the neighbourhoods where it takes place is paramount, and therefore tolerance zones seem to be a better way to achieve this objective. Like Boynton and Cusik,1 I am disappointed that the Home Office has missed the opportunity to consider tolerance zones in its strategy.

Walsall has its own prostitution and associated problems. During the …
Improved diabetic control in advanced heart failure patients treated with left ventricular assist devices
Authors: Nir Uriel, Yoshifumi Naka, Paolo C. Colombo, MaryJane Farr, Sang‐Woo Pak, Vlad Cotarlan, Jeanine B. Albu, Dympna Gallagher, Donna Mancini, Henry N. Ginsberg, Ulrich P. Jorde
Journal: European Journal of Heart Failure (2010)
Left ventricular wall motion response to intravenous propranolol.
Authors: S J Shubrooks, L M Zir, R E Dinsmore, J W Harthorne
Journal: Circulation (1975)

The effects of intravenous propranolol on left ventricular wall motion and hemodynamics were studied in 16 patients, 12 with significant coronary artery disease and four with chest pain but no coronary disease. Eight patients received 0.10 mg/kg and eight received 0.15 mg/kg of propranolol intravenously. All underwent atrial pacing at a constant rate. Left ventricular angiograms were performed before and 20 minutes after propranolol. At both doses, propranolol caused no significant change in left ventricular systolic or diastolic pressures, either before or immediately following ventriculography. Cardiac index fell significantly (3.4 plus or minus 0.2 [SEM] to 2.6 plus or minus 0.1 L/min/m-2) with the higher dose only. Of the ten patients with coronary artery disease and adequate ventriculograms, one patient had a normal left ventricle, two had regional hypokinesis, only three had areas of hypokinesis and akinesis, two had dyskinetic and akinetic areas, and two had areas of hypokinesis, akinesis and dyskinesis. No changes in regional contractility occurred with propranolol except for a minimal increase in hypokinesis in one patient at each dosage and equivocal development of a new area of slight hypokinesis in one patient and minimal apex of dyskinesis in another at the higher dosage. Of the four patients without coronary artery disease, two were affected by propranolol, one with initial regional akinesis and dyskinesis had slight worsening with propranolol and one with regional hypokinesis developed a definite new area of hypokinesis. Therefore, propranolol, even in large intravenous doses, resulted in no significant change in left ventricular wall motion in patients with coronary artery disease.
STUDIES IN DIABETES INSIPIDUS
Authors: LEONARD G. ROWNTREE
Journal: JAMA (1924)

The recent important developments in our knowledge of the pathogenesis and treatment of diabetes insipidus are intensely interesting to the medical profession. The Mayo Clinic has afforded exceptional opportunities for the clinical study of this affection, thirty-seven cases having been observed during the last four years. This report comprises the results of statistical and clinical analyses of all the cases of diabetes insipidus observed in the division of medicine of this clinic since 1910 (fifty-six in number), and a survey of the laboratory findings and results of treatment in thirty-seven cases observed during the last four years. As my own connection with the Mayo Clinic dates from 1920, the cases will be considered in two groups: Series 1, composed of nineteen cases observed between Jan. 1, 1910, and April 1, 1920, and Series 2, composed of thirtyseven cases observed between April 1, 1920, and April 1, 1924.<sup>1</sup> <h3>INCIDENCE</h3> The
Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial
Authors: María-Victoria Mateos, Albert Oriol, Joaquín Martínez-López, Norma Gutiérrez, Ana-Isabel Teruel, Ana López de la Guía, Javier López, Enrique Bengoechea, Montserrat Pérez, Marta Polo, Luis Palomera, Felipe de Arriba, Yolanda González, Jose-Mariano Hernández, Miquel Granell, José-Luis Bello, Joan Bargay, Francisco-Javier Peñalver, José-María Ribera, María-Luisa Martín-Mateos, Ramón García-Sanz, Juan-José Lahuerta, Joan Bladé, Jesús F. San-Miguel
Journal: Blood (2012)
Apolipoprotein E gene polymorphism is related to metabolic abnormalities, but does not influence erythrocyte membrane lipid composition or sodium-lithium countertransport activity in essential hypertension
Authors: P. Stiefel, C. Montilla, O. Muñiz-Grijalvo, R. Garcı́a-Lozano, A. Alonso, M.L. Miranda, E. Pamies, J. Villar
Journal: Metabolism (2001)
UK Labour party plans health changes by evolution
Authors: L. Beecham
Journal: BMJ (1997)

If the Labour party wins the general election it will end the internal market in the NHS, which it believes has led to fragmented decision making, inequity in the access to care, and increased bureaucracy.

But the shadow health secretary, Chris Smith, assured the BMA's consultants committee last week that his party planned to introduce changes by evolution rather than changing everything at once. Single practice …
SELECTIVE SUPPRESSION OF DELAYED HYPERSENSITIVITY BY THE INDUCTION OF IMMUNOLOGIC TOLERANCE
Authors: Yves Borel, Marthe Fauconnet, Peter A. Miescher
Journal: The Journal of Experimental Medicine (1966)

Administration of DNP-BGG to newborn guinea pigs resulted, in more than half of the animals, in the specific suppression of delayed hypersensitivity to DNP-BGG and BGG, as shown after immunization with DNP-BGG in complete Freund's adjuvant. In contrast, all animals formed antibodies to DNP-BGG, whether or not delayed hypersensitivity to this antigen was present. No difference in antibody titers was found between pretreated and control animals. All animals had antibodies reacting specifically to the hapten DNP, and most of them to the carrier protein BGG, whether or not delayed hypersensitivity to the carrier protein was present. Furthermore, some animals with and without positive 24 hr skin test to DNP-BGG had antibodies with a combined hapten-carrier protein specificity to this antigen, i.e., a specificity which is similar to that of delayed hypersensitivity. Thus, delayed hypersensitivity and antibody formation to similar antigenic determinant were differently affected by injection of antigen in the neonatal period. The finding that delayed hypersensitivity and antibody formation could be dissociated by the induction of immunologic tolerance supports the assumption that delayed hypersensitivity and antibody formation are different immune processes which are not necessarily linked together.
Interleukin-22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma
Authors: Oliver Waidmann, Bernd Kronenberger, Patrick Scheiermann, Verena Köberle, Heiko Mühl, Albrecht Piiper
Journal: Hepatology (2013)

Interleukin (IL)-22 is a member of the IL-10 cytokine family and is secreted by activated T cells, dendritic cells, and several different kinds of natural killer (NK)-like cells.1 IL-22 activates the transcription factor signal transducer and activator of transcription (STAT)-3 and induces an acute phase reaction. Interestingly, IL-22 acts predominantly on epithelial cells and protects hepatocytes from death.2 However, overexpression of IL-22 in the liver favors murine carcinogenesis by activation of STAT-3.3 We have recently found an association between disease severity as well as overall survival with IL-22 serum levels in patients with advanced liver cirrhosis.4 In light of the emerging key role of IL-22 in hepatocellular carcinoma (HCC),3 we assessed serum IL-22 levels in a cohort of 156 HCC patients (79.5% males) with mainly alcoholic and hepatitis C virus (HCV)-related liver disease. Concurring with other studies originating from Europe,5, 6 we recently defined a serum IL-22 concentration of 18 pg/mL as the threshold, discriminating normal from elevated systemic levels of this cytokine.4 In agreement with our previous data, we found herein also in HCC patients that elevated IL-22 levels (>18 pg/mL, R&D Systems, Quantikine) were significantly associated with shorter overall survival (OS) (P = 0.035, hazard ratio [HR] 0.491, 95% confidence interval [CI] 0.254-0.950) (Fig. 1). In multivariate Cox regression analysis with forward stepwise likelihood ratio including the dichotome variables age (≤65 years versus >65 years), gender, BCLC stage (A versus B-D), and IL-22 (≤18 pg/mL versus >18 pg/mL), high serum IL-22 was independently associated from the other factors with a shorter OS. We conclude that high serum IL-22 concentrations indicate a poor prognosis in patients with HCC and may reflect increased aggressiveness of liver cancer disease. Oliver Waidmann, M.D.1 Bernd Kronenberger, M.D.1 Patrick Scheiermann, M.D.2,3 Verena Köberle, Ph.D.1 Heiko Mühl, Ph.D.2 Albrecht Piiper, M.D., Ph.D.1 1Medizinische Klinik 1 Schwerpunkt Gastroenterologie und Hepatologie Klinikum der Goethe-Universität Frankfurt Frankfurt/Main, Germany 2Pharmazentrum Frankfurt Klinikum der Goethe-Universität Frankfurt Frankfurt/Main, Germany 3Klinik für Anästhesiologie Klinikum der Ludwig-Maximilians-Universität München, Germany
Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers.
Authors: S M Aguayo, M A Kane, T E King, M I Schwarz, L Grauer, Y E Miller
Journal: Journal of Clinical Investigation (1989)

Bombesin-related peptides are growth factors for a variety of cells, including normal human bronchial epithelial cells. An ELISA for bombesin-like peptides (BLP) has been devised using the MAb BBC353, which is specific for the biologically active carboxy-terminal fragment shared by all known BLP. Using this ELISA, we measured bronchoalveolar lavage (BAL) fluid levels of BLP in normal cigarette smokers (n = 15) and normal nonsmokers (n = 18). Smokers' BAL fluid contained increased levels of BLP, whether expressed in terms of BAL fluid volume (P = 0.0001) or protein content (P less than 0.05). BLP levels did not correlate with any cellular constituent in the BAL fluid but immunostaining of lung tissue with BBC353 revealed an intense specific staining of neuroendocrine cells, implying these as a potential source. Two peaks of bombesin-like immunoreactivity were purified using sequential reverse phase and gel filtration HPLC. Both BLP have apparent molecular weights similar to gastrin-releasing peptide on gel filtration HPLC analysis. However, the amino acid composition of these BLP is different from that of gastrin-releasing peptide or neuromedin B, the only known mammalian forms of BLP, suggesting either incomplete purification or novel peptides. Sequence analysis could not be performed due to blocking groups at the amino terminus of these peptides. Our data demonstrate that cigarette smoking is associated with increased levels of pulmonary BLP and imply a potential role for these neuropeptides in the lung's response to tobacco smoke.
The Relationship of the Degree of Coronary Atherosclerosis with Age, in Men
Authors: NEIL K. WHITE, JESSE E. EDWARDS, THOMAS J. DRY
Journal: Circulation (1950)

The amount of coronary atherosclerosis in each decade from 30 to 89 years of age, in the male, is evaluated. A large number of hearts were examined in great detail to increase accuracy. The results reveal that the degree of coronary atherosclerosis is not primarily related to age as is commonly assumed. The effect of cardiac hypertrophy on coronary atherosclerosis is also discussed.