tbuckley/cabot-search huggingface dataset:
Gastrointestinal haemorrhage and benoxaprofen.
Authors: J P Halsey, N Cardoe
Journal: BMJ (1982)

identified.This pathogenic organism was initially identified in the cyst form in the faeces of an 18-year-old woman; she had had on occasions diarrhoea, vomiting, and nausea, rarely lasting more than two to three days, during a five-month period of travel through numerous parts of India.On her travels she ate local food and drank a great deal of local water.She presented in the UK, 22 days after returning from India, with frequent bouts of diarrhoea and some rectal bleeding on defecation.Shigella flexneri was isolated from her faeces.If the bacterium had been accepted as the sole cause of her condition and microscopic examination of her faeces omitted, she may well have advanced to a serious pathological consequence, and spread the pathogen to others.This case demonstrates that, while the incidence of pathogenic Entamoeba histolytica in Britain is extremely low, importation of this dangerous pathogen does occur.For this reason it is important that patients presenting with dysenteric symptoms are carefully screened for parasitic as well as bacterial pathogens.
SIMVASTATIN-REDUCED MYOCARDIAL EDEMA RELATES TO PROTEIN KINASE A-MEDIATED REGULATION OF AQUAPORINS IN SWINE HEARTS AFTER ISCHEMIA-REPERFUSION INJURY
Authors: Xiang-Dong Li, Yue-Jin Yang, Jing-Lin Zhao, Hai-Tao Zhang, Chen Jin, Yu-Tong Cheng, Ke-Fei Dou, Jin-Qin Yuan, Yong-Jian Wu, Run-Lin Gao, Yi-Ling Wu
Journal: Journal of the American College of Cardiology (2011)
THE ABSORPTION OF OINTMENTS
Authors: R. L. Sutton
Journal: BMJ (1908)

THE SURGICAL TET91MT OF STPHILIg.museeptibls of irritation, but that very probably it is the centre from which the expulsive aetton of the uterus takes iht origin, the further inferenee being that If a placenta be unduly adherent when it happens to be located t the fundus, or that a sesille tumour grew from the undu, the uterus is stimulated to get rid of what has
Personal Burdens in Hemophilia
Authors: Richard J. Hirschman, Libby E. Ely
Journal: Annals of Internal Medicine (1972)

Editorial Notes1 October 1972Personal Burdens in HemophiliaRICHARD J. HIRSCHMAN, M.D., LIBBY E. ELY, M.S.W.RICHARD J. HIRSCHMAN, M.D.Search for more papers by this author, LIBBY E. ELY, M.S.W.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-651 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent technical advances in the production of plasma concentrates for the treatment of hemophilia have markedly improved the outlook of the hemophiliac patient. With the appropriate provisions, a wider range of activities, including travel and schooling away from home, can now be encouraged. Prophylactic treatment in selected cases (1) and home transfusion programs (2) have already minimized the painful disruption that bleeding has upon the hemophiliac's life. But, these treatment breakthroughs can significantly improve the lives of only a minority of hemophiliac patients as long as the critical economic and psychosocial problems associated with hemophilia remain unresolved.To date, there...References1. HIRSCHMANITSCOITZSHULMAN RSN: Prophylactic treatment of factor VIII deficiency. Blood 35:189-194, 1970 CrossrefMedlineGoogle Scholar2. RABINERTELFER SM: Home transfusion for hemophilia. N Engl J Med 283:1011-1015, 1970 CrossrefMedlineGoogle Scholar3. MEYERSADAMSDARDICK RWK: The social and economic impact of hemophilia. A Survey of 70 cases in Vermont and New Hampshire. Am J Public Health 62:530-535, 1972 CrossrefMedlineGoogle Scholar4. KATZHUSEK AJ: Social and vocational adaptation of the hemophiliac adult. Unpublished Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD J. HIRSCHMAN, M.D.; LIBBY E. ELY, M.S.W. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCognitive functioning, personality variables and academic achievement of hemophilic and normal children: A comparative studySPsychosocial aspects of hemophilia in families: 2. Intervention strategies and proceduresBLOOD?ITS DERIVATIVES AND ITS PROBLEMS?FACTOR VIII 1 October 1972Volume 77, Issue 4Page: 651-652KeywordsBlood plasmaHemophiliaHemorrhage ePublished: 1 December 2008 Issue Published: 1 October 1972 PDF downloadLoading ...
Complex chromosomal abnormalities in a patient with lymphoid blast crisis of chronic myelogenous leukemia
Authors: A. Haubenstock, H. J. Kim, R. Zalusky, S. C. Malamud, M. H. Mernick
Journal: American Journal of Hematology (1986)

Abstract A 46‐year‐old Chinese man underwent lymphoid blast crisis (Ia+, CALLA+, TdT+) after 5 years of chronic phase, Philadelphia‐chromosome positive chronic myelogenous leukemia. Chromosome analysis revealed a hyperdiploid karyotype, including two Philadelphia chromosomes–‐55,XY,t(9;22) (q34;q11),+2,+5,+5,+6,+10,+18,+19,+21,+del(22)(qll→qter)–‐in the majority of the leukemic blasts. The constellation of a lymphoid blast crisis and complex chromosomal abnormalities usually associated with myeloid blast crisis as well as the clinical data are discussed.
Acute Renal Insufficiency Due to Bichloride of Mercury
Authors: Paul D. Doolan, Walter C. Hess, Laurence H. Kyle
Journal: New England Journal of Medicine (1953)

THE clinical management of the oliguric patient still represents a difficult and challenging problem despite the advances in knowledge of the underlying pathologic physiology of acute renal insufficiency. The difficulties stem largely from the fundamental nature of the syndrome and the course it pursues, both of which render the patient particularly susceptible to many grave complications. The case described below illustrates a number of the complications, including massive gastrointestinal hemorrhage, and the important problem of British anti-lewisite (BAL) therapy in the oliguric patient is discussed in some detail.Case ReportM. H. (G. U. H. 28,266), a 28-year-old married woman, . . .
Cancer Stem Cells Contribute to Cisplatin Resistance in <i>Brca1/p53</i>–Mediated Mouse Mammary Tumors
Authors: Norazizah Shafee, Christopher R. Smith, Shuanzeng Wei, Yoon Kim, Gordon B. Mills, Gabriel N. Hortobagyi, Eric J. Stanbridge, Eva Y-H. P. Lee
Journal: Cancer Research (2008)

The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53-mutated tumors. At 0.5 mg/kg of daily cisplatin treatment, 80% primary tumors (n = 8) show complete pathologic response. At greater dosages, 100% show complete response (n = 19). However, after 2 to 3 months of complete remission following platinum treatment, tumors relapse and become refractory to successive rounds of treatment. Approximately 3.8% to 8.0% (mean, 5.9%) of tumor cells express the normal mammary stem cell markers, CD29(hi)24(med), and these cells are tumorigenic, whereas CD29(med)24(-/lo) and CD29(med)24(hi) cells have diminished tumorigenicity or are nontumorigenic, respectively. In partially platinum-responsive primary transplants, 6.6% to 11.0% (mean, 8.8%) tumor cells are CD29(hi)24(med); these populations significantly increase to 16.5% to 29.2% (mean, 22.8%; P < 0.05) in platinum-refractory secondary tumor transplants. Further, refractory tumor cells have greater colony-forming ability than the primary transplant-derived cells in the presence of cisplatin. Expression of a normal stem cell marker, Nanog, is decreased in the CD29(hi)24(med) populations in the secondary transplants. Top2A expression is also down-regulated in secondary drug-resistant tumor populations and, in one case, was accompanied by genomic deletion of Top2A. These studies identify distinct cancer cell populations for therapeutic targeting in breast cancer and implicate clonal evolution and expansion of cancer stem-like cells as a potential cause of chemoresistance.
Cyclic Fever in Hodgkin's Disease (Pel–Ebstein Fever)
Authors: G R Good, M J DiNubile
Journal: New England Journal of Medicine (1995)

Figure 1. A 50-year-old man had fever, night sweats, and nonproductive cough for 10 weeks. He took antipyretic medications during the febrile periods. His wife recorded his temperatures, shown above, on 56 of the 71 days. Biopsy of a rapidly enlarging cervical lymph node revealed nodular sclerosing Hodgkin's lymphoma. The patient's fevers and other symptoms promptly disappeared after the first cycle of doxorubicin, bleomycin, vinblastine, and dacarbazine.
Diet and ulcerative colitis.
Authors: G A Martini, A Stenner, W J Brandes
Journal: BMJ (1980)

The paper by Giacchino and his colleagues,7 on which your recommendations for manage- ment are so clearly based, was criticised in the subsequent discussion for its conclusions that colonoscopy should not be performed and it is surprising that you should perpetuate this erroneous conclusion.There is clearly much evidence to support a co-ordinated approach to the problem of massive bleeding from the large bowel, involving the gastroenterologist, endoscopist, radiologist, and surgeon in a joint and flexible approach to investigation and management rather than adherence to the more rigid flow chart suggested.
Acyclovir in the treatment of aplastic anemia
Authors: David Gómez‐Almaguer, Javier Marfil‐Rivera, Alex Kudish‐Wersh
Journal: American Journal of Hematology (1988)

Eight patients with idiopathic severe aplastic anemia received acyclovir as the initial treatment to ascertain if this antiviral therapy could be effective. Three patients showed improvement, but only one had a sustained recovery. The responses could be coincidental, but it seems that some patients can benefit from acyclovir. More studies are needed on the role of viruses and antiviral therapy in relation to severe aplastic anemia.
Renal vein renin measurements in children with hypertension.
Authors: M J Dillon, V Shah, T M Barratt
Journal: BMJ (1978)

Renal venous renin activity was measured in 50 children with hypertension. Main renal vein and segmental renal vein sampling was feasible in children as young as 15 months. In all cases in which there was a clear difference in renin secretion between the kidneys--that is, a main vein renin ratio above 1.5--surgery, when undertaken, successfully restored normal blood pressure. Most of the children with main renal vein renin ratios below 1.5 had bilateral disease or apparently normal kidneys. Segmental renal vein sampling contributed useful information additional to that provided by main renal vein measurements and permitted identification of local sources of renin production. In children with renal transplants who developed hypertension renal vein renin measurements helped in determining the cause and facilitating the management of the raised blood pressure.
Salaried Physicians and Economic Incentives
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1988)

Salaried physicians have recently become an important part of our health care system, and with this change have come new problems for the medical profession and the patients it serves.Not long ago the great majority of practicing physicians worked independently in their private offices on a fee-for-service basis. Now, with the growth of health care businesses and the expansion of group practices and health maintenance organizations (HMOs), more and more physicians — particularly those just starting practice — are working for a salary. According to data in the files of the American Medical Association, between one fifth and one . . .
EXPERIMENTAL PNEUMONIA IN GUINEA PIGS
Authors: Julia T. Parker
Journal: The Journal of Experimental Medicine (1929)

1. Anti-pneumotoxic sera prepared in rabbits or horses by immunization with sterile filtrates of the pneumotoxin, under certain conditions protect against the pneumonia caused by the intratracheal injections of mixtures of living pneumococci and toxic autolysates. 2. The protection against the development of pneumonia is heterologous, at least as regards Type I, Type II, viz.: an anti-autolysate serum prepared by the immunization with a pneumotoxin from one type of pneumococcus will prevent the development of pneumonia caused by the injection of pneumococci and autolysate from another type. 3. Certain anti-pneumococcus horse sera used in the treatment of pneumonia in man, either contain no heterologous pneumonia-preventing antibodies or slight amounts only. These sera, however, protect against the pneumonia produced by injections of pneumococci and pneumotoxin of the homologous strain, the degree of protection depending on the amount of specific protective substances such sera contain. 4. Anti-pneumotoxic sera produced in rabbits or horses by the injection of sterile Berkefeld filtrates of the toxic autolysates contain no pneumococcus specific protective substances.
Effects of pseudoephedrine and triprolidine, alone and in combination, on symptoms of the common cold.
Authors: C E Bye, J Cooper, D W Empey, A S Fowle, D T Hughes, E Letley, J O'Grady
Journal: BMJ (1980)

A total of 466 healthy adults from four different regions of England entered a double-blind, randomised trial to test the effectiveness of an antihistamine (triprolidine) and a decongestant (pseudoephedrine), alone or in combination, in relieving symptoms of the common cold. During the study 199 subjects reported a total of 243 colds. Subjects recorded the severity of 12 symptoms during treatment and noted separately the severity of a further seven symptoms that represented unwanted effects of treatment or served as an index of suggestibility. They were then asked about their overall improvement in symptoms during treatment and whether they thought they had taken placebo. Sneezing, nasal obstruction, and overall response to treatment were significantly improved (p &lt;0.01) with psuedoephedrine or pseudoephedrine and triprolidine compared with placebo.
Is there a role for insulin resistance in nonobese patients with idiopathic hirsutism?
Authors: Nermeen S.A. Abdel Fattah, Y.W. Darwish
Journal: British Journal of Dermatology (2009)

Hirsutism is the presence of terminal hairs in women in a male-like pattern. It may result from various causes of androgen excess or may be idiopathic. Controversies exist concerning the presence of insulin resistance in idiopathic hirsutism (IH) or if it is a manifestation of a high body mass index (BMI).To assess insulin resistance in nonobese patients with IH.The study included three groups of age- and BMI-matched nonobese women: 30 patients with IH (group 1), 20 patients with hirsutism associated with polycystic ovary syndrome (PCOS) (group 2) and 20 healthy controls (group 3). The pattern of obesity based on waist to hip ratio (WHR), and insulin resistance based on fasting insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) were assessed in all the groups.Sixteen patients with IH and 17 with PCOS had insulin resistance with statistically significant differences in fasting insulin levels and HOMA-IR between the three groups, between patients with IH and healthy controls and between patients with PCOS and healthy controls; there were no significant differences between patients with IH and patients with PCOS. When classified according to the pattern of obesity, 23 patients in group 1, 17 in group 2 and two in group 3 had a WHR >or= 0.85 (android obesity) with highly significant higher values of fasting insulin levels and HOMA-IR in patients with a WHR >or= 0.85 when compared with those with a WHR < 0.85.Insulin resistance occurs in nonobese patients with IH and appears to be related to android obesity.
Abstract P2-04-06: Successful results of a population-based organized mammography screening program in a developing country: The Turkish experience
Authors: V Ozmen, S Ozkan-Gurdal, A Kayhan, N Ozaydin, N Cabioglu, B Ozcinar, E Aribal
Journal: Cancer Research (2013)

Abstract Objective: This study aims to determine the feasibility of a population-based organized mammography screening in a developing country (Bahcesehir, Istanbul, Turkey) and to find out the starting age for screening. Material and methods: Women aged 40–69 were invited for screening at 2-year intervals starting in January 2009. Digital 2-view mammograms were obtained, and mammograms were double read by two independent radiologists who were experienced in breast imaging. The women were recalled in consensus for additional work-up including spot compression/magnification mammograms or breast ultrasound. Outcomes were measured from final assessment or histopathologic confirmation. The participation rate for second round, recall rate, number of biopsies, the women diagnosed with cancer and patient and tumor characteristics were evaluated. Results: Between January 2009 and January 2013, 5938 (89.4%) of 6640 women aged between 40-69 years old accepted mammographic invitation. Most of them (58%) were at 40-49 age group, and the average 2-year attendance for second rounds were 82.6% and 81.2%, respectively. Spot recall rates were 16.8% and 25.6% for the first and second rounds, respectively. Core biopsy was required in 108 patients (1.8%), whereas BC was diagnosed in 50 patients (0.84%). Twenty-four patients (48%) detected with BC were at 40-49 age group. There were 39 patients (78%) with invasive BC and 11 patients (22%) with ductal carcinoma in situ (DCIS). Stages of 39 patients with invasive BC were Stage I (n = 26; 52%), II (n = 10; 20%) and III (n = 3; 6%), respectively. The majority of patients (88%) had breast conserving surgery, and sentinel lymph node biopsy only (72%) as axillary procedure. Of invasive cancers, 92% were found to be hormone receptor positive, and 59% had low Ki67 levels (≤15). However, HER2-neu positivity (8%) along with triple negative cancers (3%) were less frequently detected. Conclusion: These findings suggest the prevailing view that mammographic screening increases early breast cancer detection rate which has a less aggressive biology. Screening mammography program can be successfully implemented in a developing country, Turkey effectively. However, more experienced dedicated breast cancer screening team and continuous increasing efforts are required to decrease our relatively high recall rates. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-04-06.
P1-177: The cytopathologic diagnoses of fine needle aspirations from endoscopic ultrasound of the mediastinum:Reproducibility of the diagnoses and representativeness of aspirates from lymph nodes.
Authors: Birgit G. Skov, Ulrik Baandrup, Grete K. Jakobsen, Katalin Kiss, Mark Krasnik, Kristian Rossen, Peter Vilmann
Journal: Journal of Thoracic Oncology (2007)
Abstract 3869: Proteomics highlights which G-protein coupled receptors are candidates for ADC development
Authors: Juergen Kast, Robert Boyd, James Ackroyd, Jason Allen, Amanda Anderson, Martin Barnes, Ludmila Bozhenok, Palminder Dusanjh, Lindsey Hudson, Xiaohong Yu, Dee Aud, Rahel Awdew, Arnima Bisht, Deepal Pandya, Michael Trang, Jonathan Terrett, Christian Rohlff
Journal: Cancer Research (2012)

Abstract Antibody-drug conjugates (ADCs) are a recent and exciting development for targeted therapy of cancer. Their efficacy is governed by ADC-intrinsic characteristics such as avidity, drug load and linker chemistry, and mechanisms of activation and action, which can be controlled or clarified in the early stages of ADC development. In contrast, the properties that define a promising ADC target are still somewhat unclear. OGAP is a unique proteomic database that integrates information at the tissue, disease and protein isoform level across diseases, indications, and normal tissues to clarify protein expression levels and profiles. Specifically, it currently holds information on ∼2,000,000 human protein peptide sequences, ∼16,000 human proteins sequenced, ∼7,000 cancer membrane proteins, ∼50 tissues/organs, and ∼60 diseases. Building on OGAP and a proprietary sample preparation and processing workflow that relies on state-of-the-art high-throughput mass spectrometry and data processing to provide quantitative information on over 4,000 membrane-enriched proteins from ∼ 15,000 unique peptide sequences per analysis, we have established a novel predictive tool to establish each protein's potential to serve as a target for ADC development. The tool considers proteomic and target-specific information on antigenicity, structure, function, expression level, regulation, and tissue distribution in order to highlight the most suitable candidates for ADC development. We will demonstrate the utility of this process for the protein family of G-protein coupled receptors (GPCRs), which according to a recent bioinformatics prediction encompasses 899 distinct members in the human genome. These cell surface receptors are the target of more than one third of conventional drugs, yet their potential for ADCs is largely unexplored. Here we show that proteomics in the context of the OGAP database can highlight which of this large family of receptors have the potential to become true ADC targets. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3869. doi:1538-7445.AM2012-3869
The Journal and Ethical Preparations.
Authors: J. W. Wainwright
Journal: JAMA (1900)

New York City, April 3, 1900. <h3>To the Editor:</h3> Having noticed, in an editorial inThe Journalof March 31, your determination to somewhat curtail the number and character of advertisements inThe Journalit occurred to me that you were entitled to a word of encouragement, congratulations and best wishes from the advertisers of legitimate remedies, as well as from the members of theAssociationand the profession generally. ThatThe Journalshould refuse further to encourage or give countenance to the nostrum is as it should be. Representing the most august body of medical men in the United States, voicing the sentiments and scientific thought of these men, who should head the list of individuals and organized societies in all that appertains to ethics or good morals; alive to the protection of its members and the profession generally, as well as to humanity, it should be first to
Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae.
Authors: L S McDaniel, G Scott, J F Kearney, D E Briles
Journal: The Journal of Experimental Medicine (1984)

Monoclonal antibodies were raised against surface determinants of Streptococcus pneumoniae by hyperimmunizing X-linked immunodeficient (xid) CBA/N mice with the heat-killed rough strain R36A. 17 hybridomas produced antibody that bound intact R36A and did not cross-react with phosphocholine, an antigen common in the cell wall of all S. pneumoniae. The antibody produced by at least two of these hybridomas, Xi64 (IgM) and Xi126 (IgG2b), could protect mice from a lethal intravenous challenge of type 3 S. pneumoniae strains WU2 and A66 and of the type 2 strain D39. The minimum amount of antibody required to protect xid mice from 100 WU2 was 4.5 micrograms/mouse for Xi64 and 2.6 micrograms/mouse for Xi126,. Free phosphocholine, C-polysaccharide, and type 3 capsular polysaccharide all failed to inhibit the binding of Xi64 or Xi126 to R36A. These antibodies appeared to bind surface polypeptides, since treatment of R36A with either pepsin or trypsin, or of R36A lysate with trypsin, effectively eliminated the ability of Xi64 and Xi126 to bind antigens in these preparations. Binding studies indicated that these two antibodies recognized different epitopes that were expressed on several but not all serotypes of pneumococci.