Fansidar and Pneumocystis carinii Pneumonia
Authors: P.H.J. FRISSEN
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 April 1988Fansidar and Pneumocystis carinii PneumoniaP.H.J. FRISSEN, M.D., A. STRONKHORST, M.D., J.K.M. EEFTINCK SCHATTENKERK, M.D., S.A. DANNER, M.D.P.H.J. FRISSEN, M.D.Search for more papers by this author, A. STRONKHORST, M.D.Search for more papers by this author, J.K.M. EEFTINCK SCHATTENKERK, M.D.Search for more papers by this author, S.A. DANNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-638_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Pneumocystis carinii pneumonia is the comonest opportunistic infection in the acquired immunodeficiency syndrome (AIDS). Without chemoprophylaxis after initial therapy the relapse rate is up to 80% (1). The use of fansidar (pyrimethamine-sulfadoxine) (Roche Laboratories, Nutley, New Jersey), one tablet a week, is convenient and effective in patients with cotrimoxazole intolerance (2). We report the recurrence of P. carinii pneumonia during chemoprophylaxis with fansidar in two patients.A 38-year-old homosexual man received a 2-week course of daily high-dose cotrimoxazole (960 mg of trimethoprim and 4800 mg of sulfamethoxazole) for parasitologically provenP. cariniipneumonia with good clinical result....References1. HOLLANDERGOLDENSTULBARG HJH. Recurrent AIDS-related Pneumocystis carinii pneumonia: frequency, outcome and prevention [Abstract]. In: II International Conference on AIDS. Paris: 1986:51. Google Scholar2. HARDYWOLFEGOTTLIEB DPM. Fansidar prophylaxis for Pneumocystis carinii pneumonia (PCP). In: Abstracts from the International Conference on Acquired Immunodeficiency Syndrome, 14-17 April 1985, Atlanta, Georgia. Philadelphia: American College of Physicians; 1985:25. Google Scholar3. GOTTLIEBKNIGHTMITSUYASU MSR. Prophylaxis of PCP in AIDS with pyrimethamine-sulfadoxine. Lancet. 1984;2:398-9. CrossrefMedlineGoogle Scholar4. WRIGHTRHOADSMCNEILBURKEREDFIELD DJJDR. Chemoprophylaxis prevents recurrence of Pneumocystis carinii pneumonia (PCP) in retrovirus induced immunodeficiency (AIDS) [Abstracts]. In: Abstracts from the III International Conference on AIDS, 1-5 June 1987, Washington D.C. Washington, D.C: United States Department of Health and Human Services and the World Health Organization; 1987:90. Google Scholar5. FISCHLDICKINSON MG. Fansidar prophylaxis of Pneumocystis pneumonia in the acquired immunodeficiency syndrome. Ann Intern Med. 1986;105:629. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: P.H.J. FRISSEN, M.D.; A. STRONKHORST, M.D.; J.K.M. EEFTINCK SCHATTENKERK, M.D.; S.A. DANNER, M.D.Affiliations: Academic Medical Center 1105 AZ Amsterdam, The Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPneumocystis carinii, an opportunist in immunocompromised patientsTraitement et prophylaxie de la pneumocystose au cours du syndrome d'immunodeficience acquise 1 April 1988Volume 108, Issue 4Page: 638-639KeywordsAIDSChemopreventionHomosexualsOpportunistic infectionsPneumocystis carinii pneumoniaPneumonia ePublished: 1 December 2008 Issue Published: 1 April 1988 PDF downloadLoading ...