tbuckley/cabot-search huggingface dataset:
Harlequin ichthyosis unmasked: a defect of lipid transport
Authors: A. Hovnanian
Journal: Journal of Clinical Investigation (2005)

Harlequin ichthyosis (HI)--the most severe form of keratinizing disorders, often lethal in the neonatal period--is characterized by a profound thickening of the keratin skin layer, a dense "armor"-like scale that covers the body, and contraction abnormalities of the eyes, ears, and mouth. In this issue of the JCI, Akiyama et al. report that mutations in ABCA12 caused defective lipid transport that significantly impacted normal development of the skin barrier. Lipid secretion was recovered after corrective ABCA12 gene transfer into patient keratinocytes. These results should allow for early prenatal diagnosis of HI and lend hope to the possibility of a specific treatment for this devastating disorder.
Measurement of terminal deoxynucleotidyl transferase mrna in clinical samples: A new parameter in analysis of leukemia cells
Authors: Susan C. Wolf, Peter G. Steinherz, Nathaniel R. Landau, Allen E. Silverstone
Journal: American Journal of Hematology (1987)

Abstract A 1750 base pair cDNA to human terminal deoxynucleotidyl transferase (TdT) has been cloned. This cDNA detects a dominant 2200 base pair messenger RNA species in normal and leukemic cells synthesizing the enzyme. A quantitative dot blot assay was utilized to survey a number of clinical samples from patients with TdT positive and negative leukemias as well as cells from normal volunteers. A linear relationship was detected between the amount of TdT mRNA and the amount of enzyme activity in bone marrow cells. The assay is sensitive enough to detect normal TdT levels in bone marrow, and distinguish these levels from the lack of such mRNA in peripheral blood and bone marrow of patients with myeloid leukemia. Elevated levels of mRNA were found in two cases of patients in clinical remission. The prognostic significance of these observations must await further study.
Cruzan v Director of Missouri Department of Health: An Ethical and Legal Perspective
Authors: David Orentlicher
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Variability of coronary blood flow measurements with microspheres in the rat: role of injection site and sphere number
Authors: P. A WICKER, B. P HEALY
Journal: Cardiovascular Research (1989)

Journal Article Variability of coronary blood flow measurements with microspheres in the rat: role of injection site and sphere number Get access PIERRE A WICKER, PIERRE A WICKER From the Department of Heart and Hypertension Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA Address for correspondence and reprints: Dr Pierre Wicker, MD, Department of Heart and Hypertension, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar BERNADINE P HEALY BERNADINE P HEALY From the Department of Heart and Hypertension Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 5, May 1989, Pages 443–452, https://doi.org/10.1093/cvr/23.5.443 Published: 01 May 1989 Article history Accepted: 07 December 1988 Published: 01 May 1989
C6-01: Correlations of biomarker expression and clinical outcome in a large phase III trial of pemetrexed plus cisplatin or gemcitabine plus cisplatin in chemonaive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
Authors: Giorgio Scagliotti, Christopher Kaiser, Bonne Biesma, Christian Manegold, Ulrich Gatzemeier, Piotr Serwatowski, Kostas Syrigos, Beatrix Balint, Hans J. Smit, Johan Vansteenkiste
Journal: Journal of Thoracic Oncology (2007)
Shining a Light on Shadowing
Authors: Elizabeth A. Kitsis
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Economic Sanctions and Embargoes
Authors: Anthony F. Kirkpatrick
Journal: Annals of Internal Medicine (2000)

Letters15 August 2000Economic Sanctions and EmbargoesAnthony F. Kirkpatrick, MD, PhDAnthony F. Kirkpatrick, MD, PhDUniversity of South Florida; Tampa, FL 33612-4799 (Kirkpatrick)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-4-200008150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Madeleine Albright asserts that in Cuba, “food and medicine have always been exempt from sanctions” (1). Yet Cuba's health system (operated by the Cuban government) is absolutely banned by the U.S. embargo from purchasing basic foodstuffs and is severely restricted from purchasing medicines and medical equipment from U.S. companies worldwide. The State Department has knowingly made false and misleading statements to Congress and the public about the Cuban embargo to obfuscate the agency's role in violating the most basic of universally recognized human rights.By repeatedly carrying out such deception, the State Department has made a significant ...References1. Albright MK. Economic sanctions and public health: a view from the Department of State [Editorial]. Ann Intern Med. 2000;132:155-7. LinkGoogle Scholar2. Kirkpatrick AF. The US attack on Cuba's health [Editorial]. CMAJ. 1997;157:281-4. MedlineGoogle Scholar3. U.S. House Committee on Ways and Means, Subcommittee on Trade. The State Department changes the record on Cuba: U.S. Agencies and World Health Organization misrepresented. Testimony by Anthony Kirkpatrick and Harry Vanden. Washington, DC: 7 May 1998. Google Scholar4. Kirkpatrick AF. Role of the USA in shortage of food and medicine in Cuba. Lancet. 1996;348:1489-91. CrossrefMedlineGoogle Scholar5. Impact of US Embargo on Health and Nutrition in Cuba. Washington, DC: American Association for World Health; 1997. Google Scholar Author, Article, and Disclosure InformationAuthors: Anthony F. Kirkpatrick, MD, PhDAffiliations: University of South Florida; Tampa, FL 33612-4799 (Kirkpatrick) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Health Effects of Economic Sanctions and Embargoes: The Role of Health Professionals Karine Morin , Steven H. Miles , and Economic Sanctions and Embargoes Richard Garfield Economic Sanctions and Embargoes Natalia Ganson-Myshkin Economic Sanctions and Embargoes Michèle Barry Economic Sanctions and Embargoes Michael Brumage Economic Sanctions and Embargoes Ken Freeland Economic Sanctions and Embargoes David P. Hickey Economic Sanctions and Embargoes Leila Richards Economic Sanctions and Embargoes Soheir A. Morsy Metrics 15 August 2000Volume 133, Issue 4Page: 310KeywordsDeceptionFoodInternetLegislation ePublished: 15 August 2000 Issue Published: 15 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Utilization of long-chain free fatty acids by human platelets
Authors: Arthur A. Spector, John C. Hoak, Emory D. Warner, Glenna L. Fry
Journal: Journal of Clinical Investigation (1970)

There was a rapid net uptake of free fatty acid (FFA) by human platelets when long-chain FFA, bound to human serum albumin, were incubated with platelet suspensions. Results from experiments in which both palmitate and albumin were labeled indicated that the fatty acid dissociated from the protein during uptake. Much of the FFA taken up by the platelet in short-term incubations remained in unesterified form, i.e., it was recovered as platelet FFA. As the incubation continued, increasing amounts of FFA were oxidized to CO(2) and incorporated into platelet lipid esters, particularly lecithin. Essentially all of the fatty acid that was incorporated into the platelet FFA fraction was released rapidly from the cells when they were exposed to a medium containing FFA-free albumin. The magnitude of uptake into the platelet FFA fraction was similiar at 0 degrees and 37 degrees C. Likewise, the rate and magnitude of FFA release from the platelet were similar at 0 degrees and 37 degrees C. Therefore, it is likely that both FFA uptake and FFA release occur by energy-independent mechanisms. The major effect of increasing the FFA concentration of the incubation medium was increased fatty acid uptake into the platelet FFA fraction. Similar results occurred when platelets were incubated in human plasma containing increasing amounts of added palmitate. At a given extracellular FFA concentration, considerably more of the saturated fatty acids, palmitate and stearate, were taken up as platelet FFA than either oleate or linoleate.
Skin thickness measurement by pulsed ultrasound: its reproducibility, validation and variability
Authors: C.Y. TAN, B. STATHAM, R. MARKS, P.A. PAYNE
Journal: British Journal of Dermatology (1982)

The reproducibility of the pulsed ultrasound technique for the determination of skin thickness was investigated, using two independent observers. No systematic difference was found and a high correlation was obtained. Studies were also undertaken to validate the pulsed ultrasound technique as a measure of true skin thickness. Skin thickness determined in vitro was found to be greater than when in vivo determinations were made by either the pulsed ultrasound or a xeroradiographic technique, probably due to the release of in vivo tension within the dermis after excision. Skin thickness was found to increase linearly with age up to the age of 20 years and to decrease linearly with age subsequently. Differences in skin thickness between the sexes and in different sites of the body were demonstrated.
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene
Authors: Silva Saarinen, Eevi Kaasinen, Marja-Liisa Karjalainen-Lindsberg, Kari Vesanen, Mervi Aavikko, Riku Katainen, Minna Taskinen, Soili Kytölä, Sirpa Leppä, Marja Hietala, Pia Vahteristo, Lauri A. Aaltonen
Journal: Blood (2013)
Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation.
Authors: S Devereux, T G Selassie, G Vaughan Hudson, B Vaughan Hudson, D C Linch
Journal: BMJ (1990)

OBJECTIVE--To determine the incidence of and risk factors for the development of secondary acute leukaemia and myelodysplasia in patients treated in British National Lymphoma Investigation9s studies of Hodgkin9s disease since 1970. PATIENTS--2676 Patients entered into Hodgkin9s disease studies between February 1970 and November 1986. Data accrued up to November 1988 were analysed, ensuring a minimum follow up period of two years. DESIGN--Retrospective analysis of multicentre trial data by case-control and life table methods. RESULTS--17 Cases of secondary leukaemia were recorded in this group of 2676 patients, giving an overall risk at 15 years of 1.7%. The risks of leukaemia after chemotherapy alone and chemotherapy with radiotherapy were not significantly different. The risk of leukaemia increased sharply with the amount of treatment given as measured by the number of attempts at treatment. The 15 year risks of leukaemia were 0.2%, 2.3%, and 8.1% for patients receiving one, two, or three or more attempts at treatment. The highest risk, 22.8% at 15 years, was observed in patients treated with lomustine (CCNU), and a case-control study suggested that this was an independent risk factor. The risk of secondary leukaemia was largely related to the overall quantity of treatment, although exposure to lomustine seemed to be an important risk factor. Treatment with both drugs and radiation was not more leukaemogenic than treatment with drugs alone. The greatest risk of secondary leukaemia was seen in multiply treated patients who were unlikely to be cured of Hodgkin9s disease. CONCLUSIONS--Avoidance of secondary leukaemia should be a minor factor in the choice of treatment for Hodgkin9s disease.
Abstract 5558: The expression and characterization of up-regulated inosine monophosphate dehydrogenase type 2 (IMPDH2) in colorectal adenocarcinoma tissues by proteomic analysis
Authors: Doobo Shim, Jung H. Kang, Eun S. Park, Kee R. Kang
Journal: Cancer Research (2010)

Abstract Colorectal cancer is one of the most prevalent tumors in developed countries, and the best characterized cancers with regard to genetic progression of disease. Recent improvement in methods for proteome analysis has offered the possibility of identifying disease-associated protein markers to assist in diagnosis or prognosis, and for selecting potential targets for specific drug therapy. For identification and targeting of tumor-associated marker proteins, the proteome of colorectal adenocarcinoma (CRC) and normal colorectal tissues was analyzed by 2-DE. Inosine monophosphate dehydrogenase type 2 (IMPDH2), a key enzyme of de novo purine nucleotide biosynthesis, was identified by MALDI-TOF/MS and found to be expressed at high rates in the colorectal tumor tissues. We found an increased amount of IMPDH2 mRNA in CRC compared to that observed in the normal colorectal tissues by Northern blot. Real time PCR analysis in both tissues also revealed the higher expression of IMPDH2 mRNA in CRC. Western blot analysis was carried out to confirm the elevated expression of protein level for IMPDH2 in CRC compared with normal tissues. Immunohistochemical studies denoted that tumor tissues showed higher N/C ratio, abnormal shape of gland, and darker staining in glandular area. In addition, using in situ hybridization, it was demonstrated the expression of IMPDH2 in CRC tissues was extremely high in the vicinity of mucosal gland, while IMPDH2 in the normal colorectal tissues was evenly distributed in all tissue area with lower level. These findings suggest that IMPDH2 could be a possible tumor biomarker candidate in CRC tissues. This study was supported by KOSEF grant (R13-2005-012-01003-0) and KRF grants (2006-005-J04203). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5558.
South Vietnamese Civilians Need Physicians
Authors: Phillip H. Dirmeyer
Journal: JAMA (1965)

To the Editor:—  I have read with interest the special communication in the August 9th issue ( 193 :432, 1965), concerning the need for civilian physicians in South Vietnam. The article does not give any address for prospective volunteers to use with the idea of making a 60-day tour of duty. Will you please provide this address?
Looking at Cancer Through an Evolutionary Lens
Authors: Karyn Hede
Journal: JNCI Journal of the National Cancer Institute (2009)

Over the centuries, physicians have conceptualized cancer in many ways. Hippocrates viewed it as a malfunction of black bile. In India it was treated as an imbalance of Ayurvedic principles of dosha. Modern medicine has viewed cancer in terms of genetic mutations. Now some researchers are saying we should step back and view cancer through the lens of evolution and ecology to better understand how tumors form and spread. Doing so, they say, is consistent with the current genomic view but adds dimension. Conceptualizing cancer cells as a dynamic, interacting population provides new avenues for understanding and controlling the disease. “[Evolutionary theory] is consistent with the way we understand cancer; it just describes the dynamics of that process, which people haven’t been paying that much attention to,” said Carlos Maley, Ph.D. , assistant
Drug interactions in arthritic patients.
Authors: I E Buchan, H A Bird
Journal: Annals of the Rheumatic Diseases (1991)

The drug treatment of 100 consecutive new patients admitted to a regional rheumatology centre was reviewed. Potential drug interactions actions were sought according to appendix one of the British National Formulary (September 1989) and identified in 55 of 100 patients. The clinical and laboratory features of these patients were then reviewed, showing that only 11 displayed clinical manifestations of a drug interaction. Five patients had drug induced drowsiness, which was easily corrected, five a raised serum creatinine, which was less easily corrected, and one both. Although there is considerable potential for drug interaction in patients with severe arthritis, the proportion of patients who display clinical manifestations of this is small.
Obama takes action on drugs shortages
Authors: B. Roehr
Journal: BMJ (2011)

US president Barack Obama has taken steps to help manage and perhaps ease the mounting shortage of key drugs in the United States. Much of the concern has focused on limited availability of drugs used in cancer chemotherapy. 

Among the steps is “a letter to drug manufacturers reminding them of their legal responsibilities to report the discontinuation of certain drugs to the Food and Drug Administration,” according to documents released by the White House. It also asked the manufacturers to voluntarily report potential shortages where notification is not required by law.

The president threw his support behind bipartisan legislation that would require manufacturers to report all prescription drug shortages to the FDA, and would give …
A Histologic Pattern of Nonspecific Interstitial Pneumonia Is Associated with a Better Prognosis Than Usual Interstitial Pneumonia in Patients with Cryptogenic Fibrosing Alveolitis
Authors: ZOE D. DANIIL, FRANCES C. GILCHRIST, ANDREW G. NICHOLSON, DAVID M. HANSELL, JESSICA HARRIS, THOMAS V. COLBY, ROLAND M. du BOIS
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

This study aimed to investigate whether there was a difference in outcome related to histologic pattern in cryptogenic fibrosing alveolitis (CFA) and to see whether there were correlations between clinical and radiologic findings and histology. One hundred thirteen lung biopsies from consecutive patients taken for the diagnosis of diffuse lung disease were reviewed and reclassified using the Katzenstein and Myers criteria for interstitial pneumonias. Patients lacking full investigational data at presentation and those with conditions predisposing to lung fibrosis were excluded, leaving 15 patients diagnosed with nonspecific interstitial pneumonia (NSIP) and 15 with usual interstitial pneumonia (UIP). Clinical and radiologic findings at presentation and serial lung function information and survival status in November 1998 were compared for the two groups. Survival was found to be significantly greater in the NSIP group compared with the UIP group (p < 0.001). This could not be explained by differences in treatment. Patients with UIP showed a progressive deterioration in lung function whereas those with NSIP remained stable. CT scans of patients with UIP showed more fibrosis than those of patients with NSIP (p < 0.011). A histologic diagnosis of NSIP is associated with a better prognosis than UIP. This subclassification of CFA is clinically useful.
TREATMENT OF INOPERABLE CANCER BY HYPOCHLORITES
Authors: J. E. A. G. Becker
Journal: BMJ (1909)

ThEATMENT OF' CANCERB WITIH COCAINE.[JAN. 30, I909.leak, and in some cases the, leakage is such that we have not been able to carry out the method.A slender vein can generally 'be found which answers the purpose.The pressure in the -second armlet must be lowered quickly directly the vein has been stroked empty, so that the filling of' the vein from below may be observed 'before it can leak full from above.In cases of high pressure it is difficult to get patients to endure long enough the somewhat painful feeling of pressure which results from the maintenance of the first armlet at a pressure close to the obliteration 'pressure.It is necessary to work quickly in these cases, and give a rest between each test.REFERENCES.