tbuckley/cabot-search huggingface dataset:
Spontaneous splenic rupture following the administration of intravenous heparin: Case report and retrospective case review
Authors: Michel W. Ghobrial, Mohammad Karim, Sunitha Mannam
Journal: American Journal of Hematology (2002)

Abstract We report the case of a 40‐year‐old African‐American female who presented to the Emergency Department with unstable angina. The patient, who had multiple risk factors for coronary artery disease, was admitted to the coronary care unit for cardiac work‐up and management. Shortly after the intravenous administration of unfractionated heparin, she suffered the acute onset of upper abdominal pain and shock. A CT scan of the abdomen revealed splenic rupture with hemoperitoneum. The patient, who was managed surgically, had complete recovery before discharge. A review of systems and medical records revealed no obvious risk factors or other potential etiology for this rupture. We herein provide the characteristics of this rarely documented causal relationship between heparin and spontaneous splenic rupture and retrospectively review similar cases in the literature. Am. J. Hematol. 71:314–317, 2002. © 2002 Wiley‐Liss, Inc.
THE EFFECT OF ARTERIO-SCLEROSIS UPON THE CENTRAL NERVOUS SYSTEM.Read before the Clinical Society of Maryland, January 16, 1891.
Authors: GEORGE J. PRESTON
Journal: JAMA (1891)

seems to me that careful scientific study along the lines which we have been following to-night holds out sufficient encouragement to lead us to further study.Could we treat morphine poisoning before we knew anything of the chemical properties or the physiological and toxicological effects of this alkaloid?Can we counteract or antidote the ty¬ phoid poison, before we know anything of its na¬ ture or its manner of action?I do not mean to
Abnormalities of Antroduodenal Motility in Type I Diabetes
Authors: Melvin Samsom, Rik J A Jebbink, Louis M A Akkermans, Gerard P Van Berge-Henegouwen, Andre J P M Smout
Journal: Diabetes Care (1996)

OBJECTIVE In the present study, a recently developed manometric technique was used to study antroduodenal motility in ambulant type I diabetic subjects. RESEARCH DESIGN AND METHODS In 12 patients with type I diabetes, antroduodenal manometry was performed for 20 h during the fasting period and the postprandial period after a standardized dinner and breakfast. All patients had evidence of cardiac autonomic neuropathy and complained of dyspeptic symptoms. During the manometric study, the blood glucose levels were frequently monitored and kept close to euglycemia in the diabetic patients. The results were compared with 12 healthy control subjects. RESULTS The migrating motor complex cycles observed in the diabetic subjects were longer than in the control subjects, 118.9 ± 46.0 vs. 87.0 ± 21.6 min (P &amp;lt; 0.05). This increase was attributable to a prolonged phase II, 78.0 ± 35.5 vs. 37.7 ± 18.5 min (P &amp;lt; 0.05). In the diabetic subjects, antral phase III was seen significantly &amp;lt; in the control subjects, 16.7 vs. 43.3% (P &amp;lt; 0.005). In 50% of the diabetic patients, total absence of antral phase III was observed-this phenomenon was not seen in the healthy control subjects. After dinner, the antral motility index was less in diabetic subjects compared with the healthy volunteers, indicating antral hypomotility (P &amp;lt; 0.01). Six diabetic patients showed abnormal duodenal activity such as early recurrence of phase III and bursts after dinner. No significant differences in antral motility index or in duodenal motility patterns were observed after breakfast. Six diabetic patients complained of dyspeptic symptoms after dinner, whereas none had dyspeptic symptoms after breakfast. In 67% of the patients, nausea was reported after an early phase III or a burst. CONCLUSIONS This study shows that prolonged ambulatory antroduodenal manometry is a feasible technique in patients. Recording multiple migrating motor complexes showed that interdigestive motor abnormalities of the stomach and duodenum are common in diabetic patients. Furthermore, it shows the occurrence of antral hypomotility and abnormal duodenal motility patterns after a high-calorie meal, with dyspeptic symptoms in diabetic patients being related to the composition of the meal.
The Early Complications of Cardiac Infarction
Authors: H. E. S. Pearson
Journal: BMJ (1953)

If a person survives the sudden loss by ischaemic necrosis of part of the ventricular muscle there follows a period in which special dangers threaten each of the physical systems and the personality itself.These dangers arise from two principal sources; on the one hand, from the local effects of the lesion and the circulatory depression that follows; and, on the other, from the immobility that must be imposed by the physician, together with the hazards that may attend more active treatment.
Sinus Standstill From Lidocaine
Authors: Larry Cacace
Journal: JAMA (1973)

To the Editor.—  Since Cheng and Wadhwa wrote their report of sinus standstill following intravenous administration of lidocaine (223:790, 1973), three similar cases have been published. 1-3 In these, sinus arrest occurred under one or more of the following conditions: (1)) advanced age (55, 78, and 77 years); sick sinus syndrome usually encountered in the elderly was proved in one case 2 ; (2) probable additive depression with other drugs (quinidine in one 1 and diphenylhydantoin in another 3 ) on sinoatrial node impulse formation; (3) presence of inferior wall myocardial infarction; (4) excessive dose (> 59μg/ kg/min) and other signs of toxicity, ie, dizziness and weakness.  Cheng and Wadhwa's case met most of these criteria. Their patient was elderly (88 years old) with an old inferior wall infarction, and the dose given was admittedly excessive (200 mg over five minutes) particularly in the face of severe congestive heart failure. The patient
Common Cutaneous Parasites
Authors: Alina Markova, Sarah A. Kam, Daniel D. Miller, Michael K. Lichtman
Journal: Annals of Internal Medicine (2014)

This issue provides a clinical overview of Common Cutaneous Parasites focusing on prevention, diagnosis, treatment, practice improvement, and patient information. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including ACP Smart Medicine and MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic from these primary sources in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of science writers and physician writers. Editorial consultants from ACP Smart Medicine and MKSAP provide expert review of the content. Readers who are interested in these primary resources for more detail can consult http://smartmedicine.acponline.org, http://mksap.acponline.org, and other resources referenced in each issue of In the Clinic.
Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations
Authors: M Li, L Jones, C Gaillard, M Binnewies, R Ochoa, E Garcia, V Lam, G Wei, W Yang, C Lobe, M Hermiston, E Passegué, S C Kogan
Journal: Leukemia (2013)

Although TEL-AML1 is present in one-fourth of childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL), the expression of the ETV6-RUNX1 gene encoding this fusion protein has been a poor initiator of leukemia in multiple mouse models.1, 2, 3, 4, 5, 6, 7, 8 To gain insight into why this common lesion does not readily initiate disease, we took advantage of a novel mouse model, in which TEL-AML1 expression was linked to a fluorescence marker and could be induced in a subset of hematopoietic cells during embryonic development. The laboratory of Corrinne Lobe had generated a reporter mouse in which enhanced green fluorescent protein (EGFP) was expressed following Cre-mediated excision (designated herein as ZEG mice), and subsequently generated an analogous mouse, in which a human TEL-AML1 encoding complementary DNA and an internal ribosomal entry site were placed upstream of EGFP (designated herein as TA1 mice). We crossed the inducible ZEG and TA1 mice with mice expressing Cre under the control of the Tie2(Tek) promoter, which is expressed in endothelial cells as well as during early hematopoietic development. These crosses resulted in mice carrying either the Tie2-Cre and inducible ZEG transgenes (Cre/ZEG mice) or the Tie2-Cre and inducible TA1 transgenes (Cre/TA1 mice). Mice carrying the inducible TA1 transgene but lacking Cre were also generated (Cre-/TA1+ control mice).
Quinolone ear drops for chronic otitis media
Authors: S Ghosh
Journal: BMJ (2000)

An estimated 1.5% of the adult population in the United Kingdom has active chronic otitis media with perforated tympanic membranes; this is comparable to the prevalence in western Europe and the United States. Although surgery is often necessary, antibiotic ear drops are frequently prescribed to control the discharge that patients may have with this condition. Until recently aminoglycoside ear drops were widely used, but concerns about ototoxicity, which occurs rarely, have restricted their use. Quinolone ear drops are an effective alternative, and there is good evidence from randomised controlled trials that they are the best choice for treating chronic middle ear infections.1 They are already in use in the United States, Canada, New Zealand, Japan, and other countries, although they are still not available in the United Kingdom because they have not been licensed by the Medicines Control Agency.

The principal organisms isolated from patients with chronic otitis media are …
Diseases of the Cornea
Authors: Robert A. Levine
Journal: JAMA (1980)

Dr Merrill Grayson's major interest in ophthalmology has been the cornea, and<i>Diseases of the Cornea</i>reflects his many years of experience in this field. His broad knowledge of corneal disease has enabled him to write a textbook that presents vast amounts of useful information in an organized and efficient fashion. The first half of the book is extremely well written and covers corneal anatomy, fundamentals of history taking, congenital anomalies, and the inflammatory conditions of the cornea, conjunctiva, and eyelid. The section on keratitis is particularly well written, with appropriate emphasis on the clinical, laboratory, and therapeutic aspects of corneal infections. In addition, the chapters on superior limbic keratitis and chlamydial and viral diseases are also highly informative. The tight organization and smooth flow of information are not maintained in the second half of the book. For example, in the chapter on corneal degenerations, little attention is given to
Clinical Use of an Implantable Standby Pacemaker
Authors: Victor Parsonnet
Journal: JAMA (1966)

A completely implantable pacemaker that will not compete with naturally occurring conducted beats has been used in five patients. An external model of the same design was successfully used in an additional 12 patients. The implantable model, inserted transvenously, has a single cathode in the right ventricle and an anodal plate on the surface of the power pack. The cathode serves as the sensing probe as well as the driving electrode. Although, to our knowledge, this is the first description of such an implantable device, Lemberg previously described an external "demand" pacemaker.<sup>1</sup> The merits of transvenous pacing will not be discussed here. Reference can be made to the original work of Furman et al<sup>2</sup>for unipolar pacing and Parsonnet et al<sup>3</sup>for bipolar pacing. The use of an implantable pacemaker attached to a permanent transvenous electrode has been reported by the authors and by other investigators.<sup>4</sup>
Soluble CD4: The First Step
Authors: Edmund C. Tramont, Robert R. Redfield
Journal: Annals of Internal Medicine (1990)

Editorials15 February 1990Soluble CD4: The First StepEdmund C. Tramont, MD, Robert R. Redfield, MDEdmund C. Tramont, MDSearch for more papers by this author, Robert R. Redfield, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-241 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the enormous amount of information that has so quickly emerged about the pathobiology of human immunodeficiency virus (HIV) infection, our ability to attack the virus remains quite limited. We need to replace old paradigms with new ideas.The virus's replication cycle can be divided conceptually into two parts. The first begins with binding or attachment of the virus to the host cell and entry into the cell and continues until the retroviral genome is integrated into the host cell DNA. The second part begins with transcription of HIV-specific messenger RNAs and continues through production and release of infectious virons....References1. SchooleyMeriganGaut RTP. Recombinant soluble CD4 therapy in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase I-II escalating dosage trial. Ann Intern Med. 1990;112:247-253. LinkGoogle Scholar2. KahnAllanHodges JJT. A phase I study of the safety and pharmacokinetics of recombinant CD4 (rCD4) in patients with AIDS and AIDS-related complex. Ann Intern Med. 1990:112:254-261. LinkGoogle Scholar3. WatanabeReimannDeLongLiuFisherLetvin MKPTRN. Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus in macaques. Nature. 1989;337:267-70. CrossrefMedlineGoogle Scholar4. HusseyRichardsonKowolski RNM. A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature. 1988;331:78-81. CrossrefMedlineGoogle Scholar5. GomatosStamatosGendleman PNH. Effect of soluble recombinant human CD4 (sCD4) in infectivity of six monotropic strains of HIV [Abstract]. AIDS 89: A Practical Synopsis of the V International Conference. Philadelphia: Philadelphia Sciences Group; 1989. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Walter Reed Army Institute of Research Walter Reed Army Medical Center Washington, DC 20307-5100 Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1990Volume 112, Issue 4Page: 241-242KeywordsCell bindingDNAHIVMessenger RNA Issue Published: 15 February 1990 PDF downloadLoading ...
IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity and tolerability of alternative cephalosporins
Authors: Antonino Romano, Francesco Gaeta, Rocco Luigi Valluzzi, Michela Maggioletti, Alessandra Zaffiro, Cristiano Caruso, Donato Quaratino
Journal: Journal of Allergy and Clinical Immunology (2015)
[Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction
Authors: Vahid Serpooshan, Senthilkumar Sivanesan, Xiaoran Huang, Morteza Mahmoudi, Andrey V Malkovskiy, Mingming Zhao, Mohammed Inayathullah, Dhananjay Wagh, Xuexiang J Zhang, Scott Metzler, Daniel Bernstein, Joseph C Wu, Pilar Ruiz-Lozano, Jayakumar Rajadas
Journal: Biomaterials (2014)
Health and Health Services in the United States
Authors: EDWARD J. BURGER
Journal: Annals of Internal Medicine (1974)

National investments for health in the United States have risen very rapidly and are considered very large. Costs and prices of health care have forced a public examination and discussion of many other health-related issues, one of the most important of which is the productivity of health investments (where output is measured in units of health or its equivalent). Despite public expectations of a fairly direct relation between investments in health (expenditures) and health (output), such a relation has been increasingly difficult to show. This may be a result of the crude nature of the indicators, simple inflationary characteristics of the inputs, and severe but nonmonetary limitations of the output. The validity of any one of these reasons has profound implications for public policy.
Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
Authors: Fenghua Hu, Thihan Padukkavidana, Christian B. Vægter, Owen A. Brady, Yanqiu Zheng, Ian R. Mackenzie, Howard H. Feldman, Anders Nykjaer, Stephen M. Strittmatter
Journal: Neuron (2010)
Principles of control of cancer pain
Authors: Marie Fallon, Geoffrey Hanks, Nathan Cherny
Journal: BMJ (2006)

<h3>BACKGROUND AND PURPOSE:</h3> Cavernous malformations occur most often in the brain but can occur in the spinal cord. Small studies of patients with familial cerebral cavernous malformations suggested a prevalence of spinal cord cavernous malformations of 20%–42%. We aimed to review our familial cohort and prospectively estimate the prevalence of spinal cord cavernous malformations. <h3>MATERIALS AND METHODS:</h3> We initially reviewed our familial cerebral cavernous malformations cohort for spinal cord cavernous malformations and reviewed clinical spine MR imaging examinations for sequence sensitivity. We then prospectively performed research MR imaging of the spinal cord in 29 patients from the familial cohort to estimate the prevalence. <h3>RESULTS:</h3> Gradient-based sequences identified the most spinal cord cavernous malformations on clinical MR images, forming the basis for developing our screening MR imaging. Screening spinal cord MR imaging demonstrated a prevalence of 72.4%, and a positive correlation with patient age and number of cerebral cavernous malformations. <h3>CONCLUSIONS:</h3> Spinal cord cavernous malformations occur commonly in the familial cerebral cavernous malformation population. Gradient-based sequences are the most sensitive and should be used when spinal cord cavernous malformations are suspected. This study establishes the prevalence in the familial population at around 70% and supports the idea that this condition is a progressive systemic disease that affects the entire central nervous system.
Primary pulmonary histiocytosis X in two patients with Hodgkin's disease
Authors: S. M Sajjad, M. A Luna
Journal: Thorax (1982)

The lungs may be involved in patients with histiocytosis X as part of the generalised disease, but histiocytosis X confined to the lungs without extrapulmonary involvement is rare. This report describes two cases of primary pulmonary histiocytosis arising in patients with Hodgkin9s disease. It is impossible to state with certainty whether the pulmonary histiocytosis arose as a response to the defects of cell-mediated immunity, or as a consequence of immunosuppression by radiation and chemotherapy.
Pernicious anaemia and granulomatous skin lesions in a case of common variable hypogammaglobulinaemia
Authors: KALMAN KECZKES, SHERNAZ BILIMORIA, DAVID M. PIERCY
Journal: British Journal of Dermatology (1979)

A 45-year-old woman is reported with a history of recurrent bacterial infections since childhood; at the age of 37 years she developed recurrent ulcerated lesions around her mouth, in the groins and buttocks, which histologically contained small, non-caseating granulomas. A year later when being treated for empyema, she was found to have common variable hypogammaglobulinaemia. Three years after this she developed a megaloblastic anaemia of vitamin B12-deficiency type.
Animal-Assisted Therapy Ameliorates Anhedonia in Schizophrenia Patients
Authors: Inbar Nathans-Barel, Pablo Feldman, Barry Berger, Ilan Modai, Henry Silver
Journal: Psychotherapy and Psychosomatics (2004)

Anhedonia, a component of the negative symptom dimension and a core phenomenon in schizophrenia, is associated with poor social functioning and is resistant to treatment. We tested the hypothesis that animal-assisted therapy (AAT) may improve anhedonia.To compare the effect of psychosocial treatment sessions in which a dog was an active participant (AAT) with comparable sessions without a dog, using a controlled protocol.The hedonic tone of 10 chronic schizophrenia patients who participated in 10 weekly interactive sessions of AAT was compared to a control group treated without animal assistance. The hedonic tone was measured with the Snaith-Hamilton Pleasure Scale. Subjective quality of life variables and clinical symptoms were also assessed.The AAT group showed a significant improvement in the hedonic tone compared to controls. They also showed an improvement in the use of leisure time and a trend towards improvement in motivation.AAT may contribute to the psychosocial rehabilitation and quality of life of chronic schizophrenia patients.
Evaluation of Derivation of Cardiac Output from Blood Pressure Measurements
Authors: LEON BROTMACHER
Journal: Circulation Research (1957)

This communication deals with a comparison of cardiac output in human subjects determined by the Fick method and estimates of cardiac output from arterial pressures according to formulas recently proposed by Hamilton, Remington, Starr and their respective associates. The results indicate that the cardiac output cannot be calculated from the blood pressure with any degree of accuracy.
The Utility of Adrenal Scintigraphy in Cushing??s Syndrome and Hyperaldosteronism
Authors: NAT E. WATSON, ROBERT J. COWAN, HENRY M. CHILTON
Journal: Clinical Nuclear Medicine (1985)

Thirty-three adrenal scintigrams in 30 patients were reviewed to determine the utility of this noninvasive imaging technique. It was found to be very accurate in distinguishing bilateral from unilateral hyperfunction in patients who have clinical and biochemical evidence of adrenal cortical hyperfunction. The technique proved correct in 12 of 12 cases of Cushing's syndrome and 14 of 19 cases of hyperaldosteronism. Specific clinical questions were also answered in three miscellaneous cases.
Methicillin Treatment of Severe Staphylococcal Disease
Authors: Leon D. Sabath, Bosko Postic, Maxwell Finland
Journal: New England Journal of Medicine (1962)

UNTIL recently the antibiotic treatment of serious staphylococcal disease was hampered by the emergence of resistance of the organisms to most of the available antimicrobial agents and by the toxicity of those that remained effective. The nature of staphylococcal infections, their necrotizing character and their propensity to produce walled-off abscesses also tends to render the organisms difficult to reach by circulating antibacterial substances. The isolation of 6-aminopenicillanic acid by Batchelor et al.1 has made possible the production of semisynthetic penicillins that are resistant to staphylococcal penicillinase (or penicillinases) and are as nontoxic as penicillin G, thus offering hope of an . . .
STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES
Authors: James M. Neill
Journal: The Journal of Experimental Medicine (1926)

Pneumococcus hemotoxin, an antigenic substance of bacterial origin, is converted by oxidation to a product devoid of hemolytic action. The oxidation product of the hemotoxin may be converted to the original hemolytic substance by reduction, by the anaerobic action of certain bacteria, or by sodium hydrosulfite. The active lysin, or hemotoxin, produced by the reduction of the inactive oxidized extracts is identical with the original, active, reduced hemotoxin; it possesses the same degree of thermolability and is neutralized by the same specific antibody. The inactive products formed by heating the hemotoxin anaerobically cannot be "reactivated" by reducing agents. The immunological significance of these relations will be discussed in a subsequent paper.