Parathyroid Hormone Suppression by Cimetidine in the Uremic Patient
Authors: CONNIE J. BEEHLER
Journal: Annals of Internal Medicine (1980)

Brief Reports1 December 1980Parathyroid Hormone Suppression by Cimetidine in the Uremic PatientCONNIE J. BEEHLER, M.D., JUDY R. BECKNER, M.D., ROBERT C. ROSENQUIST, M.D., STEWART W. SHANKEL, M.D.CONNIE J. BEEHLER, M.D.Search for more papers by this author, JUDY R. BECKNER, M.D.Search for more papers by this author, ROBERT C. ROSENQUIST, M.D.Search for more papers by this author, STEWART W. SHANKEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-6-840 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany of the toxic manifestations of chronic renal failure have been directly attributed to hyperparathyroidism, an almost constant feature of chronic renal failure (1). Hyperparathyroidism in chronic renal failure is believed to be secondary to retention of phosphate (2) and decreased production of calcitriol by the impaired kidney (3).Phosphate binders, a low phosphate diet, calcium, calcitriol, and intensive hemodialysis have all been used to prevent the development of hyperparathyroidism in renal failure. Despite these measures, most patients undergoing chronic hemodialysis still have marked elevations of parathyroid hormone (PTH), and some need a subtotal parathyroidectomy. Clearly, more effective ways to...References1. MASSRY S. Is parathyroid hormone a uremic toxin? Nephron. 1977;19:125-30. CrossrefMedlineGoogle Scholar2. BRICKERFINEKAPLANEPSTEINBOURGOIGNIELIGHT NLMMJA. "Magnification phenomenon" in chronic renal disease. N Engl J Med. 1978;299:1287-93. CrossrefMedlineGoogle Scholar3. AVIOLI L. Vitamin D, the kidney and calcium homeostasis. Kidney Int. 1972;2:241-6. CrossrefMedlineGoogle Scholar4. VAN THIELGAVALERSMITHPAUL DJWG. Hypothalamicpituitary-gonadal dysfunction in men using Cimetidine. N Engl J Med. 1979;300:1012-5. CrossrefMedlineGoogle Scholar5. WOLFE M. Impotence on Cimetidine treatment. N Engl J Med. 1979;300:94. Letter. CrossrefMedlineGoogle Scholar6. WINTERSBANKSLORIAUX SJD. Cimetidine is an antiandrogen in the rat. Gastroenterology. 1979;76:504-8. CrossrefMedlineGoogle Scholar7. SIMONKATHER BH. Histamine-sensitive adenylate cyclase of human gastric mucosa. Gastroenterology. 1977;73:429-31. CrossrefMedlineGoogle Scholar8. BUSSESOSMAN WJ. Decreased H2 histamine response of granulocytes of asthmatic patients. J Clin Invest. 1977;59s; 1080-7. CrossrefGoogle Scholar9. WILLIAMSHARGISBOWSERHENDERSONMARTINEZ GGEWN. Evidence for a role of adenosine 3′, 5′-monophosphate in parathyroid hormone release. Endocrinology. 1973;92:687-91. CrossrefMedlineGoogle Scholar10. MORGAN H. Endocrine control systems. In: BROBECK JR, ed. Best and Taylor's Physiological Basis of Medical Practice. 10th ed. Baltimore: The Williams and Wilkens Co. ; 1979:99. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CONNIE J. BEEHLER, M.D.; JUDY R. BECKNER, M.D.; ROBERT C. ROSENQUIST, M.D.; STEWART W. SHANKEL, M.D.Affiliations: Jerry L. Pettis Memorial Veterans' Hospital Loma Linda University School of Medicine Loma Linda, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug and Hormone Effects on Vitamin D MetabolismDrug and Hormone Effects on Vitamin D MetabolismDrug and Hormone Effects on Vitamin D MetabolismAdverse Reactions and Interactions with H2-Receptor AntagonistsCimetidine in Secondary HyperparathyroidismJ. KOVARIK, M.D., H. GRAF, M.D., W. WOLOSZCZUK, PH.D., H.K. STUMMVOLL, M.D.Nutritional Management of Chronic Renal FailureEffects of Oral Cimetidine on Parathyroid Hormone and Calcitonin Plasma Levels in Uremic PatientsRenale Osteopathie: Pathogenese und Möglichkeiten der TherapieParathyroid Hormone and CimetidineCHIKASHI KITOH, M.D. 1 December 1980Volume 93, Issue 6Page: 840-841KeywordsCalcitriolCalciumDietHyperparathyroidismKidneysParathyroid hormoneParathyroidectomyPhosphatesRenal failureResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1980 PDF downloadLoading ...