tbuckley/cabot-search huggingface dataset:
hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6
Authors: T. Egelrud, M. Brattsand, P. Kreutzmann, M. Walden, K. Vitzithum, U.C. Marx, W.G. Forssmann, H.J. Magert
Journal: British Journal of Dermatology (2005)

Several skin diseases and atopic disorders including Netherton syndrome and atopic dermatitis have been associated with mutations and deviations of expression of SPINK5, the gene encoding the human 15-domain serine proteinase inhibitor LEKTI. The biochemical mechanisms underlying this phenomenon have not yet been fully clarified.To identify target proteinases of LEKTI important for processes of desquamation and inflammation of the skin which will enable the development of specific drugs.The inhibitory activities of LEKTI domains 6 and 15 were tested on a number of commercially available serine proteinases and also on the purified kallikreins hK5 and hK7. In addition, recombinant hK5 was used.LEKTI domain 6 is a potent inhibitor of hK5 and hK7, whereas LEKTI domain 15 exhibits inhibitory activity on plasmin. hK5 and hK7 in particular are relevant to skin disorders.The inhibition of hK5 and hK7 by LEKTI domain 6 indicates an important regulatory role of LEKTI in processes of skin desquamation and inflammation, which may explain the severe pathological symptoms associated with abnormalities of SPINK5 and/or its expression. Thus, LEKTI represents a potential drug for the treatment of these disorders.
Hematopoietic Growth Factors
Authors: Arthur W. Nienhuis
Journal: New England Journal of Medicine (1988)

Experimentalists who study blood and bone marrow have long enjoyed a unique advantage: they can readily obtain those tissues and manipulate them in the laboratory to gain detailed knowledge of hematopoiesis and blood-cell function. In contrast, clinicians who treat pancytopenia in patients whose bone marrow is regenerating after transplantation, suppressed by chemotherapy, or ravaged by primary disease have usually been limited to providing optimal supportive care. Now, from the study of blood and bone marrow, greatly aided by recombinant DNA techniques in academic laboratories and biotechnology firms, has come a new class of potential therapeutic agents—the hematopoietic growth factors. Observations . . .
Factors relevant to the prognosis of chronic gastric ulcer.
Authors: D W Piper, M Greig, G A Coupland, E Hobbin, J Shinners
Journal: Gut (1975)

The factors that determine the recurrence rate of chronic gastric ulcer were studied in 105 patients. It was found that complete healing of the ulcer significantly reduced the recurrence rate and subsequent need for hospital admission because of ulcer symptoms when this group was compared with those who left hospital with their ulcers unhealed. Those admitted with large ulcers also had a higher recurrence rate. The age and sex of the patient, ingestion of analgesics and cigarette smoking did not influence recurrence. The initial healing rate of the ulcer also had no effect on the subsequent course of the patient.
Studies on a new variant of the Hermansky‐Pudlak syndrome: Qualitative, ultrastructural, and functional abnormalities of the platelet‐dense bodies associated with a phospholipase a defect
Authors: Francine Rendu, Jeanine Breton‐Gorius, Germain Trugnan, Hugo Castro‐Malaspina, Jean‐Marie Andrieu, Gilbert Bereziat, Marilyne Lebret, Jacques P. Caen
Journal: American Journal of Hematology (1978)

Abstract The structure and functions of platelets from a patient in whom albinism and hemorrhagic diathesis were associated have been investigated. Electron microscope studies showed a large reduction in the number of dense bodies and this was confirmed by an examination of fluorescent platelets loaded with mepacrine. The rare dense bodies were much bigger than normally observed; their density was diminished and was localized in a peripheral ring. Other platelet constituents were found to be normal. Platelet peroxidase activity was normal in the canaliculi of the dense tubular system; catalase‐positive granules were also present. Serotonin uptake by the patient's platelets was much decreased and reserpine, a potent inhibitor of serotonin accumulation by normal human platelets, did not further decrease this incorporation. The uptake of free 14 C‐arachidonic acid by the platelets was greatly diminished, as was its thrombin‐induced liberation from phosphatidylcholine and phosphatidyl inositol. Moreover, platelet phospholipase A 1 activity was much reduced and phospholipase A 2 activity was undetectable.
Richard John Pugh
Authors: K. Pugh
Journal: BMJ (2011)

Richard John Pugh, known as Dick, was born in Cricklewood, London, but soon moved with his family to Welshpool, to grow up above his father’s chemist shop.

On qualifying as a doctor, Richard served as a squadron leader in the Royal Air Force and was stationed in Germany for two years. He then trained as a paediatrician at Great Ormond Street, London, and, after six years as a senior lecturer in Leeds at Leeds General Infirmary and at St James’s Hospital, he took up a consultant post at Hull Royal Infirmary.

To quote my father:

“In 1939 I began at Birmingham Medical School, which was then in a new …
Multiple Stenting in Hilar Bile Duct Carcinoma: Three-Branched Partial Stent-in-Stent Deployment with the JOSTENT SelfX
Authors: H. Kawamoto, E. Ishida, T. Ogawa, Y. Okamoto, H. Okazaki, J. Kato, H. Okada, Y. Shiratori
Journal: Endoscopy (2004)

We read with great interest the paper by May et al., who reported the first preliminary results on treatment with the JOSTENT SelfX (Abbott Vascular Devices, Redwood City, California, USA), a new metallic stent for malignant biliary obstruction [1]. The article does not discuss the use of this metallic stent in the treatment of hilar biliary obstruction; we therefore decided to test a technique of triple partial stent-in-stent deployment using this device. The JOSTENT SelfX is very suitable for hilar malignant biliary obstruction.
Vascular Malformations of the Stomach and Duodenum: An Endoscopic Classification
Authors: M. Moretó, M. Figa, E. Ojembarrena, M. Zaballa
Journal: Endoscopy (1986)

Having reviewed 47 cases of vascular malformations of the stomach and duodenum, we propose an endoscopic classification for these lesions: Pattern I (flat or slightly protruded, bright red lesions with frond-like margin) is the most usual form of presentation. The "telangiectatic form" (pattern II) is an endoscopic variation, with the same clinical and, possibly, pathogenic significance. Submucosal nodular forms (pattern III) are the most difficult to diagnose and treat. Electrocoagulation is the most pertinent treatment.
PROGNOSTIC SIGNIFICANCE OF EARLY REPOLARIZATION PATTERN IN THE DIAGNOSIS OF NEUROCARDIOGENIC SYNCOPE
Authors: Victor A. Jimenez, Roberto Sierra, Eloisa Colin, David Aguilar, Carlos E. Soto, Efrain Andrade, Carlos Brambila, Edgar Lopez, Alfonso Farias, Mario R. Chapela, Enrique Lozano, Leon G. Aello, Eduardo Viveros, Jose E. Hernandez, Jose M. Portos, Jose B. Alvarez
Journal: Journal of the American College of Cardiology (2011)
Neuroleptics
Authors: Walter A. Keckich
Journal: JAMA (1978)

NEUROLEPTIC medications (eg, phenothiazines, butyrophenones) are used in medicine to control psychotic symptoms and concomitant agitated and violent behavior. They also are used to control anxiety and agitation whenever minor tranquilizers (eg, benzodiazepines) would be inappropriate. Development of akathisia as a parkinsonian side effect is confirmed in the use of these drugs. Akathisia is a condition that gives rise to the subjective desire to be in constant motion, with a feeling of inner agitation and muscle tension. The patient cannot sit still and paces constantly.<sup>1</sup> To my knowledge, however, the literature does not contain reports that the development of akathisia can precipitate violence, resulting in the behavior the drug was meant to alleviate. <h3>Report of a Case</h3> A 29-year-old man had a diagnosis of sociopathic personality and transvestism and a long history of drug abuse, including amphetamines, marijuana, alcohol, LSD, mescaline, benzodiazepines, and narcotics. The patient had a prior
Investigation is needed into why some patients are not offered cardiac rehabilitation
Authors: D. Greenwood, C. Packham, K. Muir, R. Madeley
Journal: BMJ (1996)

supplementary oxygen who are monitored by routine oximetry and given conventional seda- tion.Until this information is available, routine use of a ,B blocker for patients undergoing endo- scopic cholangiopancreatography seems prema- ture because the risk of hypotension induced by I blockade may be an additional hazard.
Regulation has not reduced food poisoning in Britain
Authors: S. Mayor
Journal: BMJ (1997)

Cases of bacterial food poisoning in the United Kingdom have increased fivefold over the past 15 years despite attempts to improve regulation, according to a report published this week by the Parliamentary Office of Science and Technology.

The report states that notifications for bacterial food poisoning in England and Wales increased from 14000 cases in 1982 to 83000 in 1996; figures for Scotland rose from 2700 to over 10000. Dr Peter Border, parliamentary adviser with the Parliamentary Office of Science and Technology, the body that provides parliament with independent analyses of scientific issues, said: “The overall picture is of a large risk in food poisoning notifications; [food poisoning]now affects almost 100000 people each year.”

Escherichia coli O157 was virtually unknown before the 1980s, but overall …
RAF plus EGFR Inhibition for BRAF-Mutant Metastatic Colorectal Cancer—Response
Authors: Rona Yaeger, Leonard B. Saltz
Journal: Clinical Cancer Research (2015)

We reported that 2 patients achieved partial responses, 8 patients achieved stable disease, and 2 patients had progression of disease by formal RECIST criteria. The RECIST measurements are graphically illustrated in the waterfall plot in Fig. 3 of our article (1). As shown in this figure, none of the patients who experienced “stable disease,” as defined by RECIST, actually had growth of their tumor on imaging studies, but rather had varied degrees of tumor shrinkage; in fact, 6 patients in the study had RECIST minor responses (10%–30% tumor shrinkage). Because the formal definition of “stable disease” is neither sufficient shrinkage to qualify for partial response nor sufficient increase to qualify for progressive disease (2), the term can describe situations in which tumors actually never regressed, and in fact grew, but simply by less than 20% at the time of first imaging. Such was not the case in our study, however. We used the word “regression” in the abstract to describe this shrinkage, and its definition is the plain English one. Clinically, tumor regression is a meaningful sign of drug activity. As noted in a study by Le Cesne and colleagues (3), the absence of progression as assessed by RECIST can predict for survival to targeted therapies, as they find that regression on RECIST measurements enables early discrimination between patients who benefited from long-term imatinib and those who did not.See the original Letter to the Editor, p. 2187R. Yaeger reports receiving commercial research support from Genentech and Novartis and is consultant/advisory board member for Amgen. L.B. Saltz is a consultant/advisory board member for Lilly, Roche, Sanofi, and Taiho.
Resistance to Drugs Associated With the Multidrug Resistance Phenotype Following Selection With High-Concentration Methotrexate
Authors: M. Haber, C. Reed, M. Kavallaris, M. D. Norris, B. W. Stewart
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Resistance to Drugs Associated With the Multidrug Resistance Phenotype Following Selection With High-Concentration Methotrexate Get access Michelle Haber, Michelle Haber Children's Leukaemia and Cancer Research Unit, Prince of Wales Children's HospitalSydney, New South Wales, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Cathie Reed, Cathie Reed Children's Leukaemia and Cancer Research Unit, Prince of Wales Children's HospitalSydney, New South Wales, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Maria Kavallaris, Maria Kavallaris Children's Leukaemia and Cancer Research Unit, Prince of Wales Children's HospitalSydney, New South Wales, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Murray D. Norris, Murray D. Norris Children's Leukaemia and Cancer Research Unit, Prince of Wales Children's HospitalSydney, New South Wales, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Bernard W. Stewart Bernard W. Stewart * Children's Leukaemia and Cancer Research Unit, Prince of Wales Children's HospitalSydney, New South Wales, Australia *Professor B. W. Stewart, Children's Leukaemia and Cancer Research Unit, Prince of Wales Children's Hospital, High St., Randwick, Sydney, NSW 2031, Australia. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 16, 16 August 1989, Pages 1250–1254, https://doi.org/10.1093/jnci/81.16.1250 Published: 16 August 1989 Article history Received: 09 May 1989 Accepted: 18 May 1989 Published: 16 August 1989
Glycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis
Authors: Nicolas Coant, Marika Simon-Rudler, Thierry Gustot, Magali Fasseu, Sonia Gandoura, Kévin Ragot, Waël Abdel-Razek, Dominique Thabut, Philippe Lettéron, Eric Ogier-Denis, Romy Ouziel, Jacques Devière, Gérard Lizard, Zéra Tellier, Didier Lebrec, Richard Moreau
Journal: Journal of Hepatology (2011)
Stimuli to Supraventricular Tachycardia
Authors: SUE COPPINGER WARREN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 March 1978Stimuli to Supraventricular TachycardiaSUE COPPINGER WARREN, M.D.SUE COPPINGER WARREN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-431_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The review "Supraventricular Tachycardia: Mechanisms and Management" by Josephson and Kastor (Ann Intern Med 87:346-358, 1977) emphasizes that sustained re-entry is the mechanism that accounts for most cases of paroxysmal supraventricular tachycardia and these arrhythmias are initiated by premature beats.In the discussion of prophylactic treatment, however, no mention is made of identification of possible precipitating stimuli such as alcohol, tobacco, and coffee. These substances may precipitate ectopic beats in normal persons (1,2). Restricted use of them, therefore, seems logical for patients with paroxysmal supraventricular tachycardia....References1. HURST J: The Heart. New York, McGraw Hill, 1974, p. 514 Google Scholar2. ZIPESMCINTOSH DH: Cardiac arrhythmias, in Cardiac and Vascular Diseases, vol. 1, edited by CONN HL JR, HORWITZ O. Philadelphia, Lea and Febiger, 1971, p. 319 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kanawha Valley Family Practice Center South Charleston, WV 25309 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1978Volume 88, Issue 3Page: 431-431KeywordsAlcoholsArrhythmiaCoffeeParoxysmal supraventricular tachycardiaTachycardia Issue Published: 1 March 1978 PDF DownloadLoading ...
Evidence-Based Medicine: A Framework for Clinical Practice
Authors: Eleanor Z. Wallace
Journal: Annals of Internal Medicine (1998)

Medical Writings15 November 1998Evidence-Based Medicine: A Framework for Clinical PracticeEleanor Z. Wallace, MDEleanor Z. Wallace, MDSUNY Health Sciences Center, Brooklyn, New YorkSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-10-199811150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Evidence-Based Medicine: A Framework for Clinical Practice; Friedland DJ, Go AS, Davoren JB, Shlipak MG, Bent SW, Subak LL, et al. 263 pages. Stamford, CT: Appleton & Lange; 1998. $26.95. ISBN 0838524761. Order phone 800-423-1359.Field of medicine: Evidence-based medicine and clinical epidemiology.Format: Softcover book.Audience: Health care professionals, medical educators, and medical trainees interested in developing proficiency in evidence-based medicine.Purpose: To serve as a resource and teaching text for persons who wish to acquire the searching, analytical, and statistical skills needed for evidence-based decision making.Content: The book is divided into three sections. The first addresses medical ... Author, Article, and Disclosure InformationAffiliations: SUNY Health Sciences Center, Brooklyn, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1998Volume 129, Issue 10Page: 839-840KeywordsClinical epidemiologyComputed axial tomographyDecision analysisDecision makingEvidence based medicineExerciseHealth careInternetLibraries ePublished: 15 August 2000 Issue Published: 15 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Topological Properties of Protein-Protein and Metabolic Interaction Networks of Drosophila melanogaster
Authors: Thanigaimani Rajarathinam, Yen-Han Lin
Journal: Genomics Proteomics & Bioinformatics (2006)

Abstract The underlying principle governing the natural phenomena of life is one of the critical issues receiving due importance in recent years. A key feature of the scale-free architecture is the vitality of the most connected nodes (hubs). The major objective of this article was to analyze the protein-protein and metabolic interaction networks of Drosophila melanogaster by considering the architectural patterns and the consequence of removal of hubs on the topological parameter of the two interaction systems. Analysis showed that both interaction networks follow a scale-free model, establishing the fact that most real world networks, from varied situations, conform to the small world pattern. The average path length showed a two-fold and a three-fold increase (changing from 9.42 to 20.93 and from 5.29 to 17.75, respectively) for the protein-protein and metabolic interaction networks, respectively, due to the deletion of hubs. On the contrary, the arbitrary elimination of nodes did not show any remarkable disparity in the topological parameter of the protein-protein and metabolic interaction networks (average path length: 9.42±0.02 and 5.27±0.01, respectively). This aberrant behavior for the two cases underscores the significance of the most linked nodes to the natural topology of the networks.
Comparison of coronary angiographic findings in acute and chronic first presentation of ischemic heart disease.
Authors: P Bogaty, S J Brecker, S E White, R N Stevenson, H el-Tamimi, R Balcon, A Maseri
Journal: Circulation (1993)

BACKGROUND It is generally assumed that the clinical manifestations of ischemic heart disease occur randomly on the same underlying pathological process. Therefore, coronary angiographic findings should be similar whether the first presentation of ischemic heart disease is acute myocardial infarction or uncomplicated chronic stable angina. METHODS AND RESULTS We studied 102 patients (men &lt; or = 60 years old, women &lt; or = 65 years old) presenting with either acute myocardial infarction as first manifestation of coronary artery disease with a concomitant coronary angiogram (55 patients; mean age, 50.2 years) or stable angina for at least 2 years with no history, ECG, or left ventriculographic evidence of any acute event and with an angiogram performed at least 2 years after initial symptoms (47 patients; mean age at symptom onset, 51.7 years). These angiograms were evaluated blindly for severity (number of vessels diseased, stenoses &gt; or = 50%, occlusions), extent of disease (with an index derived by assigning a score of 0-3 per segment, depending on the proportion of lumen length irregularity and dividing the sum by the number of visualized segments), and pattern (discrete: three or fewer loci of disease never involving more than 50% of the length of any segment or diffuse: anything exceeding this). Patients with unheralded myocardial infarction had fewer vessels diseased, fewer stenoses and occlusion, and a lower extent index than those with uncomplicated stable angina (mean +/- SD of 1.3 +/- 0.8 versus 2.1 +/- 0.8, p &lt; 0.001; 2.1 +/- 1.8 versus 3.9 +/- 1.8, p &lt; 0.001; 0.6 +/- 0.6 versus 1.0 +/- 0.9, p &lt; 0.02; and 0.6 +/- 0.5 versus 1.2 +/- 0.5, p &lt; 0.001, respectively). A discrete pattern was present in 54.5% of patients with unheralded infarction and in only 8.5% of those with uncomplicated angina (p &lt; 0.001). CONCLUSIONS These very different angiographic findings suggest that unheralded acute myocardial infarction and uncomplicated chronic stable angina do not occur randomly on a common atherosclerotic background but rather that additional factors, such as a varying propensity to thrombosis, may predispose to one or the other of these two clinical syndromes.
The hemodynamic derangement associated with right ventricular diastolic collapse in cardiac tamponade: an experimental echocardiographic study.
Authors: P P Leimgruber, H S Klopfenstein, L S Wann, H L Brooks
Journal: Circulation (1983)

Clinical reports indicate that right ventricular diastolic collapse (RVDC) is associated with cardiac tamponade. To assess the hemodynamic abnormalities associated with RVDC, we studied six chronically instrumented conscious dogs (group A) with two-dimensional echocardiography during cardiac tamponade induced by continuous saline infusion into the pericardial space. We recorded cardiac output (electromagnetic flowmeter), heart rate, respiration, and aortic, intrapericardial, and right atrial pressures. In four additional animals (group B), we recorded right ventricular pressure and placed a hydraulic occluder around the pulmonary artery so that short-term reversible obstruction to right ventricular outflow could be produced. None of the dogs had RVDC when the pericardial space was empty, but all dogs showed RVDC during cardiac tamponade. The appearance of RVDC in group A was associated with a 21% reduction in cardiac output (p less than .01) and no change in mean aortic pressure. Short-term partial pulmonary artery obstruction led to increased right ventricular pressures and a striking reduction in RVDC in early tamponade, suggesting that RVDC is caused by pericardial pressure exceeding right ventricular pressure in early diastole. An additional animal had right ventricular hypertrophy caused by a severe "heart worm" infestation and did not show RVDC during cardiac tamponade. These observations suggest that in the absence of increased resistance to right ventricular outflow or right ventricular hypertrophy, RVDC occurs early in the course of cardiac tamponade and is associated with a hemodynamically important decrease in cardiac output.
Generalized Cytomegalic Inclusion Disease after Renal Homotransplantation
Authors: E. T. Hedley-Whyte, J. E. Craighead
Journal: New England Journal of Medicine (1965)

CYTOMEGALIC inclusion disease occurs infrequently in adults and is usually an incidental post-mortem finding.1 This report records the isolation of cytomegalovirus§ from an adult who died with generalized cytomegalic inclusion disease after receiving a renal homograft. The studies of Smith3 and Weller et al.4 established the association of this disease in young children with cytomegalovirus infection. The relation of the virus to disease in the adult has not been established.Case ReportJ.T., an 18-year-old student, was admitted to the Peter Bent Brigham Hospital with uremia secondary to chronic pyelonephritis. Peritoneal dialysis was instituted. Renal Homotransplantation was carried out on . . .