tbuckley/cabot-search huggingface dataset:
Microtubule Associated Protein Tau Expression as a Predictive and Prognostic Marker in a Trial Assessing Sequential Docetaxel as Adjuvant Chemotherapy for Early Breast Cancer (TACT).
Authors: A. Tutt, C. Gillett, S. Pinder, R. A'Hern, M. Dowsett, I. Ellis, J. Bartlett, J. Bliss, S. Johnston, P. Ellis, . TACT Trial Trialists
Journal: Cancer Research (2009)

Abstract Objective: TACT, which compared sequential anthracycline-taxane (FEC-D) adjuvant chemotherapy with an anthracycline regimen of similar duration (Lancet 2009:373, 1681-1692) provides an opportunity to correlate tau expression levels with disease-free survival (DFS) and to explore the interaction between tau expression and docetaxel benefit. Patients and Methods: 4162 patients were randomized to FE60C (fluorouracil, epirubicin and cyclophosphamide,- 4 cycles) followed by docetaxel (4 cycles) or control. Control, determined by local centres, was FE60C (8 cycles) or epirubicin (4 cycles) followed by classical CMF (cyclophosphamide, methotrexate and fluorouracil - 4 cycles). Patients with hormone receptor positive tumours also received adjuvant endocrine treatment. Tissue blocks were obtained for 3610 TACT patients (87 % of total) to create tissue microarrays (TMA). Tau protein expression was assessed by immunohistochemistry (IHC). Tau was successfully scored by 2 observers (blinded to treatment allocation and clinical outcome), scoring 2 cores from separate TMAs for each of 2977 patients. Intensity (negative, weak, moderate or strong) and the proportion of tumour cells stained (in 5% increments) were recorded. Results: A very strong association was observed between level of intensity and proportion of staining (p&amp;lt;0.001), subsequent analysis used tau intensity only. Fifty one percent of tumors were tau-positive defined as demonstrating weak or greater intensity of staining. Tau expression was positively correlated with ER status (p&amp;lt;0.001), negatively correlated with grade (p&amp;lt;0.001) and negatively correlated with HER2 status (p&amp;lt;0.001). In absence of overall treatment benefit for docetaxel, significant factors predicting DFS on univariate analysis were tau, ER and HER-2 expression in addition to nodal status, grade, tumour size and age. With the exception of age these variables were also significant on multivariate analysis. No significant interaction between tau expression and efficacy of docetaxel was observed in all patients or in patients within the ER+HER2-ve, HER2 +ve and ER -ve HER2 –ve subsets. Exploratory analyses to assess interactions using tau intensity and proportion IHC staining as continuous variables are underway and will be reported. Conclusion: Tau expression was associated with improved DFS but there was no evidence of an interaction between tau and docetaxel benefit. These results are similar to NSABP-B28, which evaluated addition of paclitaxel to doxorubicin/cyclophosphamide. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 607.
SOME UNUSUAL EFFECTS OF QUININ ON THE SKIN.
Authors: J. SCHNECK
Journal: JAMA (1894)

Perhaps the most common dermal effect of quinin, when administered internally, is a form of hives or urticaria in which the surface is fairly covered with irregular shaped reddish colored blotches, varying in size from that of a dime to the palm of the hand. The skin is slightly elevated, has a hard, tense feel to the touch; there is usually intolerable itching and burning; sometimes the skin is so sensitive that even the slightest touch causes severe pain and feels as if a raw surface had been touched. In other cases the eruption is in the form of a rash, similar to that seen in scarlet fever. Often there is a uniform flush of the surface of the skin as in an erythema. Quite frequently a herpetic eruption follows the administration of quinin, which may be located on the lips, ear, cheek or prepuce. I have a lady patient
NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis
Authors: Massimo Vitale, Cristina Bottino, Simona Sivori, Lorenza Sanseverino, Roberta Castriconi, Emanuela Marcenaro, Raffaella Augugliaro, Lorenzo Moretta, Alessandro Moretta
Journal: The Journal of Experimental Medicine (1998)

After culture in interleukin (IL)-2, natural killer (NK) cells acquire an increased capability of mediating non–major histocompatibility complex (MHC)–restricted tumor cell lysis. This may reflect, at least in part, the de novo expression by NK cells of triggering receptors involved in cytolysis. In this study we identified a novel 44-kD surface molecule (NKp44) that is absent in freshly isolated peripheral blood lymphocytes but is progressively expressed by all NK cells in vitro after culture in IL-2. Different from other markers of cell activation such as CD69 or VLA.2, NKp44 is absent in activated T lymphocytes or T cell clones. Since NKp44 was not detected in any of the other cell lineages analyzed, it appears as the first marker specific for activated human NK cells. Monoclonal antibody (mAb)–mediated cross-linking of NKp44 in cloned NK cells resulted in strong activation of target cell lysis in a redirected killing assay. This data indicated that NKp44 can mediate triggering of NK cell cytotoxicity. mAb-mediated masking of NKp44 resulted in partial inhibition of cytolytic activity against certain (FcγR-negative) NK-susceptible target cells. This inhibition was greatly increased by the simultaneous masking of p46, another recently identified NK-specific triggering surface molecule. These data strongly suggest that NKp44 functions as a triggering receptor selectively expressed by activated NK cells that, together with p46, may be involved in the process of non-MHC-restricted lysis. Finally, we show that p46 and NKp44 are coupled to the intracytoplasmic transduction machinery via the association with CD3ζ or KARAP/DAP12, respectively; these associated molecules are tyrosine phosphorylated upon NK cell stimulation.
Analysis of T cell hybridomas. II. Comparisons among three distinct types of monoclonal suppressor factors.
Authors: K Okuda, M Minami, M Furusawa, M E Dorf
Journal: The Journal of Experimental Medicine (1981)

Five hybridoma T cell lines were prepared by fusion of Ts3 cells with the BW 5147 thymoma. The culture supernatants from these T cell hybrids contained a factor, TsF3, which specifically suppressed 4-hydroxy-3-nitrophenyl acetyl hapten (NP(-hapten cutaneous sensitivity responses. The properties of this new series of hybridoma factors was compared with those of two previously characterized types of NP-specific suppressor factors (TsF1 and TsF2). TsF3 activity was only observed if the factor was administered during the effector phases of the immune response. TsF3 bears I-J and C57BL anti-NP antibody idiotypic determinants and has binding specificity for the NP hapten. Furthermore, TsF3 does not suppress H-2 (I-J)-incompatible mice. In addition to this H-2 restriction, the monoclonal TsF3 factors also demonstrated an Igh genetic restriction. Finally, the TsF3 factors could be distinguished by their ability to suppress cyclophosphamide-treated recipients.
Management training for clinicians
Authors: T J Wood
Journal: BMJ (1986)

~mu 81986 that is the electrocardiogriphicdreading.-ITfact that a patient has hypertension does not change that-reading.Howiver,-the ined cincin wih confldencein thehistoryandbloodpssures alues may then conclude that left ventricularhyper- trophyis more likely ;
King's College Hospital puts pathology services into public-private partnership
Authors: C. White
Journal: BMJ (2010)

An NHS foundation trust in London has formed an alliance with an existing public-private partnership to become the United Kingdom’s largest single provider of pathology services.

King’s College Hospital NHS Foundation Trust announced on 21 September that its pathology services, called KingsPath, would be consolidating with GSTS Pathology, the existing joint venture between Guy’s and St Thomas’s NHS Foundation Trust and the commercial company Serco Group.

Serco already has several public sector contracts in the health, education, transport, science, and defence sectors, and its healthcare provision includes out of hours services, occupational health, and facilities management. KingsPath has one of the UK’s largest portfolios of specialist pathology tests.

The new tripartite arrangement, which starts on 1 October, is expected to carry out more than 10 million tests a year. It will provide pathology services for both London trusts, Bedford Hospital NHS Trust, and several other NHS and independent sector organisations. …
Kidney kinase network regulates renal ion cotransport
Authors: Nati Hernando, Carsten Wagner, Jürg Biber, Heini Murer
Journal: Journal of Clinical Investigation (2007)

Protein kinases catalyze the phosphorylation of serine/threonine or tyrosine residues, which may directly alter a protein’s functional properties. Kinases can also regulate protein functions indirectly, for example, by controlling the composition and/or subcellular localization of members of multiprotein complexes that associate with the regulated protein. In this issue of the JCI, two separate studies by Weinman et al. and Yang et al. examine the second of these two modes of kinase-mediated regulation and demonstrate the effects of kinases on two Na+-driven renal cotransporters (see the related articles beginning on pages 3403 and 3412). Their results reveal important implications for phosphate and salt homeostasis, respectively.
Medicine—Why I Left You
Authors: Beatriz M. Rodriguez
Journal: Annals of Internal Medicine (2003)

Ad Libitum20 May 2003Medicine—Why I Left YouBeatriz M. Rodriguez, MDBeatriz M. Rodriguez, MDRockford, IL 61103Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-10-200305200-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I left you because you left me firstI left you because I found you in bed with anotherI left you because I could no longer find the goodpeople with whom I shared cadaversI left you because you lied to meYou said you would never let business come in the way ofOur loveI left you because you made love to corporate AmericaI left you because you mistook ethics for the appearance of ethicsI left you because you lost control of yourselfDining with CEOs and CFOs and market shareI left you ... Author, Article, and Disclosure InformationAffiliations: Rockford, IL 61103Current Author Address: Beatriz M. Rodriguez, MD, 5125 Solitude, Rockford, IL 61114. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 May 2003Volume 138, Issue 10Page: 850KeywordsFatsHeartInterleukins ePublished: 20 May 2003 Issue Published: 20 May 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Haemoptysis, weight loss, and pulmonary shadowing in a smoker
Authors: T. Jordan, M. J. Ledson, K. Mohan
Journal: BMJ (2010)

A 53 year old white man was referred with a four week history of productive cough and right sided chest pain. He had chronic obstructive pulmonary disease and was a retired upholsterer who smoked 30 cigarettes a day and consumed 140 units of alcohol a week. Clinical examination was normal. Sputum culture yielded Haemophilus influenzae , but despite several courses of antibiotics he failed to improve, developing weight loss, exertional dyspnoea, and haemoptysis.

Blood investigations showed normocytic anaemia, with mild neutrophilia and an erythrocyte sedimentation rate of 86 mm in the first hour. Serum electrolytes, calcium, and liver profile were normal. Computed tomography showed opacities in the right middle and lower lobes involving the chest wall but with no bony destruction, with right hilar and axillary lymphadenopathy (fig 1⇓). A fibreoptic bronchoscopy was unremarkable, but bronchial washings confirmed the presence of H influenzae . 

The patient then developed smooth firm non-fluctuant but warm tender swellings on both sides of his chest. Core biopsies and aspirations of the lung lesion, chest wall masses, and axillary lymph node showed inflammatory changes with no evidence of malignancy or infection. Culture for tuberculosis was negative. Excision biopsy of the chest wall lesion was sent for haematoxylin and eosin staining (fig 2⇓) and later Grocott’s silver methenamine staining (fig 3⇓).



Fig 1 Computed tomogram of the chest





Fig 2 Haematoxylin and …
The Incidence of Leukemia in Radiologists
Authors: Helmuth Ulrich
Journal: New England Journal of Medicine (1946)

EXPOSURE to x-rays has for some time been regarded as a possible cause of leukemia. This belief is based in part on results obtained by experimental exposure of animals to x-rays1 2 3 4 and in part on several reports of cases of leukemia occurring in workers exposed to radiation.5 6 7 8 9 10 11 12 13 14 15 Definite proof of such an etiologic relation has not been established, however, and some authors have expressed doubt concerning it. Thus, Evans and Roberts8 stated in 1928, after a review of the literature to that date, "Although the possibility of causal association cannot positively be denied, the evidence is not conclusive." Haagensen9 wrote, . . .
Effect of Reserpine on Salivary Gland Radiolodine Uptake in Thyroid Cancer
Authors: HOWARD A. LEVY, CHAN H. PARK
Journal: Clinical Nuclear Medicine (1987)

Nine patients with thyroid cancer were treated with reserpine in an attempt to reduce radiation exposure to the salivary glands from 100-150 mCi doses of I-131 therapy to thyroid remnants or metastases. Three control patients were not treated with reserpine but did receive 100-150 mCi of I-131. Parotid/background ratios of activity after radioablative doses of I-131 in patients not treated with reserpine were significantly higher than the patients treated with reserpine, and this was also true seven days after the radioablative dose. Combined therapy with reserpine, chewing gum, lemon candies, and hydration is suggested for the prevention of sialadenitis and xerostomia due to large doses of radioiodine.
Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners
Authors: Jens Peter E Bonde, Erik Ernst, Tina Kold Jensen, Niels Henrik I Hjollund, Henrik Kolstad, Thomas Scheike, Aleksander Giwercman, Niels Erik Skakkebæk, Tine Brink Henriksen, Jørn Olsen
Journal: The Lancet (1998)
Clinical trials update from the European Society of Cardiology Heart Failure Meeting 2010: TRIDENT 1, BENEFICIAL, CUPID, RFA‐HF, MUSIC, DUEL, handheld BNP, phrenic nerve stimulation, CHAMPION and CABG with CRT study
Authors: John G.F. Cleland, Alison P. Coletta, Andrew L. Clark
Journal: European Journal of Heart Failure (2010)
Spinal Fluid Prolactin
Authors: IVAN S. LOGIN
Journal: Annals of Internal Medicine (1977)

Comments1 January 1977Spinal Fluid ProlactinIVAN S. LOGINIVAN S. LOGINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-119 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In reference to the excellent work reported by Jordan and associates (1) I would like to make several points. The elevation of cerebrospinal fluid (CSF) prolactin should more properly be looked on as a nonspecific response to alterations in the serum hormone concentration rather than a manifestation of extrasellar growth of a pituitary tumor.This is substantiated by the increased CSF prolactin reported in association with conditions of non-neoplastic hyperprolactinemia either naturally occuring—during pregnancy or neonatal life (2), proestrous in rats (3), or iatrogenic—after intravenous prolactin injection into rabbits (3), or in treatment of patients with psychoactive...References1. JORDANKENDALLSEAICH RJJ: Cerebrospinal fluid hormone concentration in the evaluation of pituitary tumors. Ann Intern Med 85:49-55, 1976 LinkGoogle Scholar2. ASSIESTOUBER JJ: Prolactin in plasma and cerebrospinal fluid (abstract). The Endocrine Society, abstract #116, p. 114, 1976 Google Scholar3. CLEMENSSAWYER JB: Identification of prolactin in CSF. Exp Brain Res 21:399-402, 1974 CrossrefMedlineGoogle Scholar4. SEDVALL G: Prolactin levels in plasma and cerebrospinal fluid of psychiatric patients in relation to treatment with psychoactive drugs. Eur J Clin Pharmacol, in press Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHormonal changes in headache patientsCerebrospinal fluid prolactin: a daily rhythm and response to an acute perturbationCerebrospinal Fluid Pituitary Hormone Concentrations in Patients with Pituitary TumorsPituitary Hormone Concentrations in Cerebrospinal Fluid in Patients with Pituitary Tumors 1 January 1977Volume 86, Issue 1Page: 119-120KeywordsAttentionCerebrospinal fluidColony stimulating factorGrowth hormonePatientsPituitary tumorsPregnancyProlactinRabbits Issue Published: 1 January 1977 PDF DownloadLoading ...
Hydroxyurea therapy for sickle cell disease in community‐based practices: A survey of Florida and North Carolina hematologists/oncologists
Authors: Marc S. Zumberg, Suresh Reddy, Robert L. Boyette, Robert J. Schwartz, Thomas R. Konrad, Richard Lottenberg
Journal: American Journal of Hematology (2005)

Abstract Little is known about patterns of hydroxyurea (HU) use by community‐based hematologist/oncologists (H/Os) for the treatment of sickle cell disease (SCD). Determination of these practice patterns pertaining to adult SCD patients was the focus of this study. A self‐administered survey was mailed to H/Os in two southeastern states. Replies were received from 70% of eligible physicians. This study focuses on responses from 184 community H/Os and a comparison group of 30 university‐based/affiliated H/Os providing ongoing care for at least 3 SCD patients/month. The majority of community H/O respondents saw less than 3 SCD patients/month. HU was prescribed by more than half (55%) of community H/Os in at least 10% of their patients. The most common reasons cited for prescribing HU include frequent painful crises (76%), chronic pain with frequent narcotic use (58%), and acute chest syndrome (43%). Although the majority of community H/Os care for few patients with SCD, the reported indications for HU were consistent with currently accepted recommendations. However, community H/Os reported acute chest syndrome, stroke, and pulmonary hypertension as indications for HU less often than the academic H/O group. Barriers to wider use of HU include physician concerns about carcinogenic potential, doubts about HU effectiveness, perceived patient apprehension about adverse effects, concern about lack of contraceptive use, and patient compliance. Further resources should focus on updating physicians on recently published material supporting the effectiveness of HU in symptomatic SCD as well as providing management guidelines to optimize the use of HU. Am. J. Hematol. 79:107–113, 2005. © 2005 Wiley‐Liss, Inc.
ASSESSMENT OF ATRIAL LATE POTENTIALS IN PATIENTS WITH HYPERCHOLESTEREMIA, TO INVESTIGATE THE PREVENTIVE EFFECT OF PITAVASTATIN ON ATRIAL FIBRILLATION (ALPINA STUDY)
Authors: Yuji Okuyama, Yuki Kuramoto, Masato Kawasaki, Yusuke Iwasaki, Koji Tanaka, Yoshio Furukawa, Takashi Morita, Takahisa Yamada, Hiromichi Ueda, Issei Komuro, Masatake Fukunami
Journal: Journal of the American College of Cardiology (2012)
Primary health care and adolescence
Authors: A. Macfarlane, A. McPherson
Journal: BMJ (1995)

authorities on an equitable basis to help with the startup and recurrent running costs of local out of hours general practice rotas above the level of individual practices.Available for this financial year and subject to review in subsequent years, this money amounts to an additional 55% of the current costs of night visiting in general practice and shows the government's own calculations of the extent of its underfunding of the out ofhours service as a whole.Funds may be awarded only for projects initiated and operated by general practitioners.Responsibility for the development of cooperative rotas and new methods of delivering out of hours care is therefore to fall solely on general practitioners' shoulders.Success will depend on whether a professional group that perceives itself to be in a crisis oflow morale and recruitment7 can muster the necessary reserves of energy and enthusiasm to develop a better service at night.The task is a substantial challenge, given the current high level of call outs, the rising number of 999 ambulance calls, and the progressively increasing rates of attendance at hospital accident and emergency departments.The need for a responsive primary care service at night, separately organised and separately funded from the contract for general medical services, has never been more urgent.This deal hardly seems to bring us any nearer to its achievement.
Arterial influx, efflux and tissue content of albumin in rabbits in vivo
Authors: S P BRASCH, J N FINKELSTEIN, G MAKHANI, S GHOSH
Journal: Cardiovascular Research (1984)

Journal Article Arterial influx, efflux and tissue content of albumin in rabbits in vivo Get access S P BRASCH, S P BRASCH From the Biochemistry Program, Northwestern University Medical and Dental Schools, Chicago, IL 60611, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar J N FINKELSTEIN, J N FINKELSTEIN * From the Biochemistry Program, Northwestern University Medical and Dental Schools, Chicago, IL 60611, USA *Present address: University of Rochester School of Medicine, Rochester, New York, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar G MAKHANI, G MAKHANI From the Biochemistry Program, Northwestern University Medical and Dental Schools, Chicago, IL 60611, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar S GHOSH S GHOSH From the Biochemistry Program, Northwestern University Medical and Dental Schools, Chicago, IL 60611, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 4, April 1984, Pages 244–248, https://doi.org/10.1093/cvr/18.4.244 Published: 01 April 1984
Clotting Problems in Young Adults
Authors: Hugh H. Hussey
Journal: JAMA (1975)

An earlier editorial inThe Journal(230:1018, 1974) told of a report by Pirkle and Carstens<sup>1</sup>about sudden death in six persons consequent to widespread plugging of small pulmonary arteries and arterioles by platelet aggregates. All six patients were young; their ages ranged from 17 to 40 years. The suddenness of their death had precluded studies of the clotting properties of their blood—notably platelet hyperaggregability. In the January issue of<i>Archives of Neurology</i>(32:13-20, 1975), Kalendovsky et al report the finding of repeated cerebrovascular occlusions in four young patients (ages, 20 to 38 years). Three were women, two of whom were receiving birth control pills at the time they were first seen. All four patients had evidence of plasma hypercoagulability. Many months later, while not taking oral contraceptive agents and while receiving warfarin sodium therapy, two of the women and the man developed new cerebrovascular symptoms. At this time,