Absence of Lymphocyte Immunoglobulin Production in Chronic Lymphocytic Leukemia and Multiple Myeloma
Authors: JAMES P. CROWLEY
Journal: Annals of Internal Medicine (1977)

Letters1 June 1977Absence of Lymphocyte Immunoglobulin Production in Chronic Lymphocytic Leukemia and Multiple MyelomaJAMES P. CROWLEY, M.D., W. HALOWELL CHURCHILL, M.D., JAMES SIMON, PH. D., MAURICE M. ALBALA, M.D., F.A.C.P.JAMES P. CROWLEY, M.D.Search for more papers by this author, W. HALOWELL CHURCHILL, M.D.Search for more papers by this author, JAMES SIMON, PH. D.Search for more papers by this author, MAURICE M. ALBALA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-6-750 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe combination of chronic lymphocytic leukemia and multiple myeloma is a rare and noteworthy combination of diseases (1). We recently treated a patient with both these diseases. Since recent studies (2, 3) have emphasized the depressive effect of multiple myeloma on normal lymphocyte immunoglobulin production, we thought it sufficiently of interest to report the results of our study of the immunoglobulin production of her abnormal peripheral blood lymphocytes.The patient was an 80-year-old widow hospitalized initially because of back pain secondary to a compression fracture of T10. Her past history included a resection of a localized carcinoma of the cervix...References1. CRYERKISSANE PJ: Multiple malignancies: chronic lymphocytic leukemia, malignant melanoma, multiple myeloma and acute myelomonocytic leukemia. Am J Med 58:408-416, 1975 CrossrefMedlineGoogle Scholar2. BRODERHUMPHREYDURM SRM: Impaired synthesis of polyclonal (non-paraprotein) immunoglobulins by circulating lymphocytes from patients with multiple myeloma. Role of suppressor cells. N Engl J Med 293:887-892, 1975 CrossrefMedlineGoogle Scholar3. CHENBHOOPALAMYAKULIS YNV: Changes in lymphocyte surface immunoglobulins in myeloma and the effect of an RNA-containing plasma factor. Ann Intern Med 83:625-631, 1975 LinkGoogle Scholar4. ROWLANDSDANIELE DR: Surface receptors in the immune response. N Engl J Med 293:26-32, 1975 CrossrefMedlineGoogle Scholar5. HORWITZLOBO DP: Characterization of two populations of human lymphocytes bearing easily detectable surface immunoglobulin. J Clin Invest 56:1464-1472, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Clinical Hematology Rhode Island Hospital and Brown University Providence, Rl 02902 Department of Medicine Harvard Medical School Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnostic and Clinical Considerations in Concomitant Bone Marrow Involvement by Plasma Cell Myeloma and Chronic Lymphocytic Leukemia/Monoclonal B-Cell Lymphocytosis: A Series of 15 Cases and Review of LiteratureThe association of chronic lymphocytic leukaemia and multiple myeloma: a study of eleven patientsTransformation of chronic lymphocytic leukemia to plasmacytomaPlasma Cell Neoplasms and Acute LeukaemiaChronic Lymphocytic Leukaemia with Subsequent Development of Multiple Myeloma 1 June 1977Volume 86, Issue 6Page: 750-751KeywordsBloodCervixChronic lymphocytic leukemiaLower back painLymphocytesMultiple myeloma ePublished: 1 December 2008 Issue Published: 1 June 1977 PDF downloadLoading ...