tbuckley/cabot-search huggingface dataset:
Letter: Volunteers and the aftermath of stroke.
Authors: M Edwards
Journal: BMJ (1975)

disease.Whatever the extent of the risk (and it is not clear what the committee considers to be a "low" risk), in my view there is a very strong case for compensating the parents of those children who are handicapped by such a reaction.Although evidence has been presented on behalf of the Association of Parents of Vaccine Damaged Children to the Royal Commission on Civil Liability and Compensation for Personal Injury, it is unlikely that legislation will ensue for some time, and at best it is unlikely to be retroactive.The Joint Committee on Vaccination would do well to back its benign reassurance about pertussis vaccine with strong support for the speedy introduction of a State compensation scheme.
Surgeons develop composite bone transplants
Authors: D. Josefson
Journal: BMJ (1999)

Composite bone transplants using cadaveric and host bone may become a standard method of repairing bony defects. A 6 year old boy, Adam Johnson, underwent this pioneering procedure nine months ago and has shown good results.

Adam lost most of his humerus to cancer and faced the choice of further amputation and a prosthesis or the experimental procedure. Orthopaedists …
Calyceal-Perirenal Fistula
Authors: FREDERICK W. SPONG
Journal: Annals of Internal Medicine (1970)

The first reported case of calyceal-perirenal fistula as a complication of percutaneous renal biopsy occurred in a 20-year-old woman with systemic lupus erythematosus. This complication produced hematuria and flank discomfort, and pooling of contrast material outside of the kidney was demonstrated by intravenous pyelography. The tract was partially closed when pyelography was repeated 2 days later.
Opening doors to medicine
Authors: Sean Hilton, Kenton Lewis
Journal: BMJ (2004)

Widening participation must sit alongside top up fees 

Today's universities must compete and thrive in an evolving and fast moving international market. The current funding gap in higher education in the United Kingdom must be bridged if institutions are to do so, and the government sees increased fees for students as part of the solution. Despite much controversy the proposed implementation of a system of top up fees for students in England and Wales is now established at the top of the higher education agenda.1

In considering the impact on universities of top up fees the government's own commitment to increasing and widening participation is of major importance—namely, that 50% of those aged 18-30 are to have higher education experience by 2010. The relation between top up fees and widening participation is problematic. The people who are working to tackle commitments to widening participation are faced with apparently mutually exclusive policy positions—to raise participation by “debt averse” people in a system perceived to increase personal financial burden. …
ESWL and Gallstone Dissolution with MTBE via a Naso-Vesicular Catheter
Authors: N. Soehendra, H. Schulz, V. Ch. Nam, A. Maydeo, J. P. Schenkengel, H. Grimm, M. Brueckner, B. Eckmann, H. W. Schreiber
Journal: Endoscopy (1990)

Endoscopic placement of a naso-vesicular catheter was successful in 90% (45/50) of patients with cholecystolithiasis. The first 7 patients were treated by MTBE dissolution alone. Dissolution was discontinued after a maximum of 14 days, as only two patients were rendered stone free. In one patient, 3 tiny pigment stones were sucked out through the catheter, and in another inoperable patient a pigtail endoprosthesis was finally inserted into the gallbladder. In the remaining 36 patients, combined ESWL and MTBE dissolution therapy was carried out. Treatment was broken off by one patient after one week, and interrupted in another due to catheter dislodgement. After an average of 10 days with 1-9 ESWL sessions (average: 3) complete stone clearance was achieved in 60% (20/34) of patients. Fourteen of the patients who completed treatment, and the one with catheter dislodgement still have sludge in the gallbladder, which is being treated with oral bile acids. The procedure-related complication rate was 10% (3 pancreatitis, 1 cystic duct perforation and 1 guidewire impaction). The mortality rate was zero. There was no evident complication due to either ESWL or MTBE dissolution.
Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GH-deficient adults. II. Effects on serum lipoproteins and lipoprotein and hepatic lipase activity
Authors: Jan Oscarsson, Malin Ottosson, Jan-Ove Johansson, Olov Wiklund, Per Mårin, Per Björntorp, Bengt-Åke Bengtsson
Journal: Metabolism (1996)
Medicare Coverage of Preventive Care Services
Authors: Charles Preston, Miriam Alexander
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MODERN VIEWS ON THE PHYSIOLOGY AND PATHOLOGY OF ACCOMMODATION.
Authors: None CARL
Journal: JAMA (1907)

In bringing before you some modern views on accommodation I hope to be able to satisfy both those who are interested in theoretical investigations and those who prefer the discussion of more practical questions. Few problems stand in such an intimate connection both with theoretical and with practical ophthalmology, and in the last twenty years there has been much discussion on points of great importance. It is on these points that I wish to speak. Since Thomas Young, more than a hundred years ago, first proved that accommodation must be caused by changes in the shape of the lens, and since Cramer and Helmholtz have shown us that these changes may be seen and measured by studying the Purkinje reflex images, two theories have been put forward to explain how these changes in the size of the lens might be brought about. Helmholtz believed that contraction of the ciliary muscle
Impact of autologous blood injections in treatment of mid-portion Achilles tendinopathy: double blind randomised controlled trial
Authors: K. J. Bell, M. L. Fulcher, D. S. Rowlands, N. Kerse
Journal: BMJ (2013)

<b>Objective</b> To assess the effectiveness of two peritendinous autologous blood injections in addition to a standardised eccentric calf strengthening programme in improving pain and function in patients with mid-portion Achilles tendinopathy. <b>Design</b> Single centre, participant and single assessor blinded, parallel group, randomised, controlled trial. <b>Setting</b> Single sports medicine clinic in New Zealand. <b>Participants</b> 53 adults (mean age 49, 53% men) with symptoms of unilateral mid-portion Achilles tendinopathy for at least three months. Participants were excluded if they had a history of previous Achilles tendon rupture or surgery or had undergone previous adjuvant treatments such as injectable therapies, glyceryl trinitrate patches, or extracorporeal shockwave therapy. <b>Interventions</b> All participants underwent two unguided peritendinous injections one month apart with a standardised protocol. The treatment group had 3 mL of their own whole blood injected while the control group had no substance injected (needling only). Participants in both groups carried out a standardised and monitored 12 week eccentric calf training programme. Follow-up was at one, two, three and six months. <b>Main outcome measures</b> The primary outcome measure was the change in symptoms and function from baseline to six months with the Victorian Institute of Sport Assessment-Achilles (VISA-A) score. Secondary outcomes were the participant’s perceived rehabilitation and their ability to return to sport. <b>Results</b> 26 participants were randomly assigned to the treatment group and 27 to the control group. In total, 50 (94%) completed the six month study, with 25 in each group. Clear and clinically worthwhile improvements in the VISA-A score were evident at six months in both the treatment (change in score 18.7, 95% confidence interval 12.3 to 25.1) and control (19.9, 13.6 to 26.2) groups. The overall effect of treatment was not significant (P=0.689) and the 95% confidence intervals at all points precluded clinically meaningful benefit or harm. There was no significant difference between groups in secondary outcomes or in the levels of compliance with the eccentric calf strengthening programme. No adverse events were reported. <b>Conclusion</b> The administration of two unguided peritendinous autologous blood injections one month apart, in addition to a standardised eccentric training programme, provides no additional benefit in the treatment of mid-portion Achilles tendinopathy. <b>Trial registration</b> Australian New Zealand Clinical Trials Registry ACTRN12610000824066, WHO U1111-1117-2641.
572 THE EFFECT OF D-MELD ON GRAFT SURVIVAL AND COURSE OF HCV RECURRENCE IN HCV-RNA POSITIVE RECIPIENTS AFTER LIVER TRANSPLANTATION
Authors: F. Tandoi, R. Romagnoli, G. Catalano, G. Rizza, I. Giono, N. Gilbo, P. Strignano, F. Lupo, M. Salizzoni
Journal: Journal of Hepatology (2011)
Doxorubicin and Ventricular Arrhythmia
Authors: THOMAS M. COSGRIFF
Journal: Annals of Internal Medicine (1980)

Letters1 March 1980Doxorubicin and Ventricular ArrhythmiaTHOMAS M. COSGRIFF, M.D.THOMAS M. COSGRIFF, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-434_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently the cases of three patients were reported in which during or shortly after doxorubicin infusion (1), two of the patients died suddenly and one developed ventricular tachycardia and fibrillation. Sudden death has been reported in another patient who was receiving doxorubicin (2). Apart from sinus tachycardia, arrhythmia is an uncommon complication of doxorubicin therapy (3). Reactions during infusion are usually allergic in type and minor in degree.I have seen the onset of ventricular arrhythmia during doxorubicin infusion in a 21-year-old man with acute myelogenous leukemia. After infusion of about 60 mg over 1 minute, he developed...References1. WORTMAN J, LUCAS V, and SCHUSTER E. Sudden death during doxorubicin administration. Cancer. 1979;44:1588-91. CrossrefMedlineGoogle Scholar2. O'BRYAN R, LUCE J, and TALLEY R. Phase II evaluation of adriamycin in human neoplasia. Cancer. 1973;32:1-8. CrossrefMedlineGoogle Scholar3. VON HOFF D, ROZENCWEIG M, LAYARD M, SLAVIK M, and MUGGIA F. Daunomycin-induced cardiotoxicity in children and adults. Am J Med. 1977;62:200-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS M. COSGRIFF, M.D.Affiliations: Fort Detrick; Frederick, MD 21701 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStem Cell-Derived Exosomes Ameliorate Doxorubicin-Induced Muscle Toxicity through Counteracting PyroptosisSudden Death Late After Doxorubicin Administration: Use of Electrophysiological Study and Treatment by Automatic Implantable Cardioverter DefibrillatorEffects of first-dose doxorubicin on cardiac rhythm as evaluated by continuous 24-hour monitoringArrhythmias in Patients with Drug Toxicity, Electrolyte, and Endocrine DisturbancesClinical Presentations of Doxorubicin-Induced CardiotoxicityMyocardial injury immediately following adriamycin administrationCytostatic and immunosuppressive drugsDoxorubicin and the HeartROLAND A. LEVANDOWSKI, M.D. 1 March 1980Volume 92, Issue 3Page: 434-435KeywordsAcute myeloid leukemiaAllergy and immunologyArrhythmiaAtrial fibrillationTachycardiaVentricular tachycardia ePublished: 1 December 2008 Issue Published: 1 March 1980 PDF downloadLoading ...
Nanooncology: The future of cancer diagnosis and therapy
Authors: Avnesh S. Thakor, Sanjiv S. Gambhir
Journal: CA A Cancer Journal for Clinicians (2013)

Abstract In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. Nanoparticles have unique biological properties given their small size and large surface area‐to‐volume ratio, which allows them to bind, absorb, and carry compounds such as small molecule drugs, DNA, RNA, proteins, and probes with high efficiency. Their tunable size, shape, and surface characteristics also enable them to have high stability, high carrier capacity, the ability to incorporate both hydrophilic and hydrophobic substances and compatibility with different administration routes, thereby making them highly attractive in many aspects of oncology. This review article will discuss how nanoparticles are able to function as carriers for chemotherapeutic drugs to increase their therapeutic index; how they can function as therapeutic agents in photodynamic, gene, and thermal therapy; and how nanoparticles can be used as molecular imaging agents to detect and monitor cancer progression. CA Cancer J Clin 2013;63:395‐418 . © 2013 American Cancer Society, Inc.
Hidden operators of mental attention applying on LTM give the illusion of a separate working memory
Authors: Juan Pascual-Leone
Journal: Behavioral and Brain Sciences (2004)

The authors' results support a functionalist conception of working memory: a manifold repertoire of schemes/schemas (long-term memory) and a small set of general-purpose “hidden operators.” Using some of these operators I define mental (i.e., endogenous) attention. Then, analyzing two of the authors' unexplained important findings, I illustrate the mental-attention model's explanatory power. Multivariate methodology that varies developmental, task differences, and individual differences is recommended.
Effect of acetaminophen on glutathione levels in rat testis and lung.
Authors: L Micheli, D Cerretani, A I Fiaschi, G Giorgi, M R Romeo, F M Runci
Journal: Environmental Health Perspectives (1994)

Glutathione (GSH) levels in rat testis and lung after oral administration (3 g/kg) of acetaminophen (APAP) were studied. At the administered dose APAP is present in each organ and influences the GSH levels. APAP value of 114 micrograms/g was obtained in testis at 6 hr (peak time); in the lung the Cmax was 92 mu/g at 8 hr and this value lasted several hours longer than that in testis. GSH levels are also affected differently in the organs studied after APAP administration; the lungs seem to be the primary organ undergoing the depleting action of APAP. This process could not only cause toxicity, but also predispose those organs to the action of toxic compounds responsible for specific pathologies.
Who Killed the Indiana Provider? Elementary, Vendor Wilson
Authors: Glenda A. Wilson
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I agree with Dr Biondo.<sup>1</sup>I work in my husband's medical office. On our county department of public welfare claim form for the State of Indiana, it declares that my husband is not a doctor or provider. No, he is a vendor.
Fas expression at diagnosis as a biomarker of azacitidine activity in high-risk MDS and secondary AML
Authors: S. S. Ettou, E. E. Audureau, C. C. Humbrecht, B. B. Benet, Hélène Jammes, T. T. Clozel, V. V. Bardet, C. C. Lacombe, F. F. Dreyfus, P. P. Mayeux, E. E. Solary, M. M. Fontenay
Journal: Leukemia (2012)
Electrophysiologic Mechanisms of the Long QT Interval Syndromes and Torsade de Pointes
Authors: Hanno L. Tan, Charles J. Y. Hou, Michael R. Lauer, Ruey J. Sung
Journal: Annals of Internal Medicine (1995)

Purpose: To review the current understanding of the mechanisms and treatment of the long QT interval syndromes and torsade de pointes. Data Sources: Personal databases of the authors and a search of the MEDLINE database from 1966 to 1994. Study Selection: Experimental and clinical studies and topical reviews on the electrophysiologic mechanisms and treatment of torsade de pointes were analyzed. Results: The long QT interval syndromes have been classified into acquired and hereditary forms, both of which are associated with a characteristic type of life-threatening polymorphic ventricular tachycardia called torsade de pointes. The acquired form is caused by various agents and conditions that reduce the magnitude of outward repolarizing K+ currents, enhance inward depolarizing Na+ or Ca2+ currents, or both, thereby triggering the development of early afterdepolarizations that initiate the tachyarrhythmia. The hereditary form appears to result from an abnormal response to adrenergic or sympathetic nervous system stimulation. At least some cases of the hereditary long QT interval syndromes may result from a single gene defect that alters the intracellular regulatory proteins responsible for the modulation of K+ channel function. Treatment of the acquired form is primarily directed at identifying and withdrawing the offending agent, although emergent therapy using maneuvers and agents that favorably modulate transmembrane ion currents can be lifesaving. In torsade de pointes associated with the hereditary long QT interval syndromes, early diagnosis leading to treatments designed to both shorten the QT interval and block the β-adrenergic-induced instability of the QT interval is essential. Conclusions: The long QT interval syndromes and torsade de pointes are potentially life-threatening conditions caused by various agents, conditions, and genetic defects. The mechanisms responsible for these conditions and available treatment options for them are reviewed.
Angiographic predictors of reocclusion after thrombolysis: Results from the thrombolysis in myocardial infarction (TIMI) 4 trial
Authors: C. Michael Gibson, Christopher P. Cannon, Robert N. Piana, Jeffrey A. Breall, Barry Sharaf, Margaret Flatley, Barbara Alexander, Daniel J. Diver, Carolyn H. McCabe, Greg C. Flaker, Donald S. Baim, Eugene Braunwald
Journal: Journal of the American College of Cardiology (1995)

This study attempted to determine which lesion characteristics are associated with reocclusion by 18 to 36 h.Reocclusion of the infarct-related artery after successful reperfusion is associated with significant morbidity and up to a threefold increase in mortality.Two hundred seventy-eight patients with acute myocardial infarction were randomized to receive either anisoylated plasminogen streptokinase activator complex (APSAC) or recombinant tissue-type plasminogen activator (rt-PA) or their combination. Culprit arteries were assessed for Thrombolysis in Myocardial Infarction (TIMI) flow grade, lesion ulceration, thrombus, collateral circulation and eccentricity. Minimal lumen diameter, percent diameter stenosis and lesion irregularity (power) were calculated using quantitative angiography.Reocclusion was observed more frequently in arteries with TIMI 2 versus TIMI 3 flow (10.4% vs. 2.2%, p = 0.003), in ulcerated lesions (10.7% vs. 3.0%, p = 0.009) and in the presence of collateral vessels (18.2% vs. 5.6%, p = 0.03). Similar trends were observed for eccentric (7.3% vs. 2.3%, p = 0.06) and thrombotic (8.4% vs. 3.3%, p = 0.06) lesions. Reocclusion was associated with more severe mean percent stenosis (77.9% vs. 73.9%, p = 0.04). Lesion length, reference segment diameter and Fourier measures of lesion irregularity were not associated with reocclusion.Several simply assessed angiographic variables, such as the presence of TIMI grade 2 flow, ulceration, collateral vessels and greater percent diameter stenosis at 90 min after thrombolytic therapy, are associated with significantly higher rates of infarct-related artery reocclusion by 18 to 36 h and may aid in identifying the subset of patients who are at significantly higher risk of early reocclusion and who potentially warrant further early pharmacologic or mechanical intervention.
Africa has a right to support from international community in its fight against HIV/AIDS, malaria, and tuberculosis
Authors: H. McConnell
Journal: BMJ (2003)

Africa has a right to demand support from the international community in its fight against AIDS, tuberculosis, malaria and other diseases, Professor Jeffrey Sachs, executive director of the Earth Institute at Columbia University, told a meeting of African heads of state in Maputo, Mozambique last week.

Professor Sachs said that only a very small fraction of the more than $10bn (£6.2bn; €8.8bn) needed each year to effectively combat these illnesses had yet been allocated to African countries.

By the middle of May, the Global Fund to fight AIDS, …
Tympanometry in the Diagnosis of Middle-Ear Effusion
Authors: Paul A. Shurin, Stephen I. Pelton, Joan Finkelstein
Journal: New England Journal of Medicine (1977)

Tympanometry measures the flow of sound energy in the external ear canal under conditions of changing ear-canal pressure. To evaluate this technic as a means of detecting middle-ear effusion, we studied acoustic susceptance and conductance in 91 children. We made the measurements using tones of 220 and 660 Hz over a pressure range of -300 to +300 mm of water. The mean value for susceptance at 660 Hz gave best results: 83 of 84 tympanograms of ears with middle-ear effusion had values less than 0.16 millimhos (mmho). Among 128 studies of normal ears, 113 had values greater than or equal to 0.16 mmho (P less than 0.001). We conclude that a mean acoustic susceptance at 660 Hz less than 0.16 mmho in a child four months of age or older indicates the presence of middle-ear effusion.
Cardiac Pathology: An Integrated Text and Colour Atlas
Authors: Pamela Ouyang
Journal: JAMA (1985)

In the past two decades, rapid advances have occurred in our understanding of the mechanism of normal cardiac contraction and of the effects of aging and disease on cardiac function. Much of this increase in knowledge has been the result of dramatic improvements in diagnostic imaging techniques, such as two-dimensional echocardiography and a variety of nuclear imaging techniques. More aggressive approaches to patients with common diseases—such as thrombolytic interventions in coronary thrombosis and intra-aortic balloon counterpulsation in patients with unstable angina or with complications from infarction—in conjunction with advances in surgical treatment for such patients have resulted in a need for greater appreciation of cardiac pathology. Thus, although a detailed understanding of cardiac morphology has always been essential to pediatric cardiologists and cardiothoracic surgeons, internists, cardiologists, and radiologists now require an appreciation of the morphological manifestations of cardiovascular disorders. This handsome atlas of cardiac pathology is an exciting edition. The