tbuckley/cabot-search huggingface dataset:
Cancer/Testis Antigen Expression in Human Mesenchymal Stem Cells: Down-regulation of <i>SSX</i> Impairs Cell Migration and Matrix Metalloproteinase 2 Expression
Authors: Garth Cronwright, Katarina Le Blanc, Cecilia Götherström, Pádraig Darcy, Monika Ehnman, Bertha Brodin
Journal: Cancer Research (2005)

Abstract Several families of genes by and large located on the X chromosome encode proteins of unspecified function. Commonly known as cancer/testis (CT) antigens, they are considered, under normal conditions, only to be expressed in cells of the germ line and placenta. CT genes are also often expressed in cancer cells, hence their classification. Here we report that their expression in normal cells is wider spread and can be observed in cells with the potential for self-renewal and pleuripotency, namely, stem cells. Several CT genes and their products, CT antigens, including SSX, NY-ESO-1, and N-RAGE, were expressed in undifferentiated mesenchymal stem cells (MSCs) and down-regulated after osteocyte and adipocyte differentiation. To elucidate the possible overlapping function played by these genes in cancer and stem cells, a comparative analysis of the localization of their proteins was made. In addition, localization relative to other MSC markers was examined. This revealed that SSX localizes in the cytoplasm and overlap occurs in regions where matrix metalloproteinase 2 (MMP2) and vimentin accumulate. Nevertheless, it was found that no protein interactions between these molecules occur. Further investigation revealed that the migration of a melanoma cell line (DFW), which expresses SSX, MMP2, and vimentin, decreases when SSX is down-regulated. This decrease in cell migration was paralleled by a reduction in MMP2 levels. Analogous to this, SSX expression is down-regulated in MSCs after differentiation; concomitantly a reduction in MMP2 levels occurs. In addition, E-cadherin expression increases, mimicking a mesenchymal epithelial transition. These results afford SSX a functional role in normal stem cell migration and suggest a potentially similar function in cancer cell metastases.
New Endobronchial Ultrasound Imaging for Differentiating Metastatic Site Within a Mediastinal Lymph Node
Authors: Takahiro Nakajima, Masato Shingyouji, Hiroki Nishimura, Toshihiko Iizasa, Sachiko Kaji, Kazuhiro Yasufuku, Hideki Kimura
Journal: Journal of Thoracic Oncology (2009)
Sweet savage love: FA, BO, and SES in the EEA
Authors: Edward H. Hagen, Nicole Hess
Journal: Behavioral and Brain Sciences (2000)

Proxies of mate value must be evolutionarily salient. Gangestad &amp; Simpson (G&amp;S) have made a good case that fluctuating asymmetry is an important proxy of male mate value that correlates well with genetic and developmental quality. The use of financial variables as proxies for male investment ability by Gangestad, Simpson, and virtually every other investigator of human mating in evolutionary perspective, is, however, more problematic.
Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring
Authors: L. Keski‐Nisula, J. Pekkanen, B. Xu, T. Putus, P. Koskela
Journal: Allergy (2006)

Maternal use of oral contraceptive pills (OCPs) might increase the prevalence of allergic diseases among offspring. The aim of the study was to clarify if there are differences between OCP types in this association.Primary outcomes were asthma, allergic rhinitis and atopic eczema among 1182 children (618 asthmatic and 564 controls) aged 5-6 years.Maternal previous use of desogestrel, gestodene or cyproterone acetate before pregnancy, each combined with ethinyloestradiol (EO), increased the risk of allergic rhinitis among offspring compared with those children whose mothers had not used OCPs (OR 1.67, 95% CI 1.07-2.59, P < 0.024), and this risk was increased mainly in those children with parental allergy (OR 1.78, 95% CI 1.11-2.86, P < 0.018), especially in boys (OR 2.12, 95% CI 1.17-3.84, P < 0.014). No associations were observed between maternal use of OCPs before pregnancy and asthma or atopic eczema among offspring. The association between the previous use of OCPs and allergic rhinitis was not mediated through maternal sex steroid levels during early pregnancy, but women who had used more androgenic types of progestin formulas had higher serum levels of progesterone during early pregnancy.Maternal previous use of desogestrel, gestodene or cyproterone acetate before pregnancy, each combined with EO, increased the risk of allergic rhinitis among offspring compared with those children whose mothers had not used OCPs and this risk was detected mainly in boys and in children with parental allergy.
Universal hepatitis A vaccination of young children is leading to disappearance of hepatitis A in adolescents and adults
Authors: D. Shouval, Y. Ashur, J. Victor, A. Monto, B. Bell, H. Margolis, R. Adler, O. Nainan, N. Daudi, R. Almogi, A. Leventhal
Journal: Journal of Hepatology (2003)
Textbook of Parasitology
Authors: J. Walter Beck
Journal: JAMA (1965)

Belding's<i>Textbook of Parasitology</i>has long been noted as a classic among workers in this field. The third edition of this text follows essentially the same format as that of the second. The recent advances in parasitology since the last publication are included and the updating of the text is apparent throughout the various chapters. The use of tables, graphic representations, and keys to facilitate study, so prevalent in the former edition, is continued and improved upon in some sections. Deletions of some are wisely made. The new illustrations of the leishmanian and malarial parasites improve the presentation of these diseases. Credit for the chapters on diagnosis and diagnostic methods is given to Dr. Alice T. Marston, while Dr. Matthew A. Derow wrote the chapters on the treatment of parasitic diseases. Both sections represent extensive revision of old material and the presentation of new data. While the former edition, notable
Platelet Counts in Infants of Women with Autoimmune Thrombocytopenia
Authors: Margaret Karpatkin, Robert F. Porges, Simon Karpatkin
Journal: New England Journal of Medicine (1981)

THE obstetrical management of women with autoimmune thrombocytopenic purpura (ATP) is controversial. Because of transplacental passage of antiplatelet antibody, children of these women are frequently born with low platelet counts, and there is concern that pressure on the head during vaginal delivery may bring about intracranial hemorrhage. For this reason, most authors have advocated that infants of mothers with this disease be delivered by cesarean section.1 2 3 4 5 Others have recommended vaginal delivery unless there is some recognized obstetrical indication for section.6 , 7 We have examined the effect of administering corticosteroids to the mother before delivery in order to raise the infant's platelet . . .
Renal function after long-term treatment with lithium.
Authors: R P Hullin, V P Coley, N J Birch, T H Thomas, D B Morgan
Journal: BMJ (1979)

Daily urine volumes, plasma creatinine concentrations, and creatinine clearance were measured in 106 patients with unipolar and bipolar affective disorders attending a "lithium" clinic. Urine volumes exceeded 3.51 in only six patients, plasma creatinine concentrations exceeded 150 mumol/1 (1.7 mg/100 ml) in only five, and creatinine clearance was below 50 ml/min in 16. Renal function was assessed by measuring creatinine clearance and renal tubular function, including response to 20 hours of water deprivation, in a representative sample of 30 patients from the lithium clinic and 30 psychiatric patients matched for age and sex who were taking other psychotropic drugs. Creatinine clearance and tubular function, including urine osmolality after water deprivation, were not significantly different between the two groups. Urinary excretion of arginine vasopressin (AVP), however, was much greater in the lithium-treated patients, who therefore had a diminished tubular responsiveness to AVP. The findings do not support suggestions that long-term lithium treatment results in seriously impaired renal function, renal damage, and polyuria. Compared with other series, however, the patients were being maintained with low serum lithium concentrations, which apparently area as effective prophylactically as higher concentrations.
Disturbances in Leptin Metabolism Are Related to Energy Imbalance during Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Authors: EVA C. CREUTZBERG, EMIEL F. M. WOUTERS, INGRID M. L. VANDERHOVEN-AUGUSTIN, MIEKE A. DENTENER, ANNEMIE M. W. J. SCHOLS
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Previously we reported an impaired energy balance in patients with chronic obstructive pulmonary disease (COPD) during an acute disease exacerbation, but limited data are available on the underlying mechanisms. Experimental and clinical research supports the hypothesis of involvement of the hormone leptin in body weight and energy balance homeostasis. The aim of this study was to investigate the course of the energy balance in relation to leptin and the soluble tumor necrosis factor (TNF) receptors (sTNF-R) 55 and 75, plasma glucose, and serum insulin in patients with severe COPD during the first 7 d of hospitalization for an acute exacerbation (n = 17, 11 men, age mean [SD] 66 [10] yr, FEV1 36 [12] %pred). For reference values of the laboratory parameters, blood was collected from 23 (16 men) healthy, elderly subjects. On admission, the dietary intake/resting energy expenditure (REE) ratio was severely depressed (1.28 [0.57]), but gradually restored until Day 7 (1.65 [0.45], p = 0.005 versus Day 1). Glucose and insulin concentrations were elevated on admission, but on Day 7 only plasma glucose was decreased. The sTNF-Rs were not different from healthy subjects and did not change. Plasma leptin, adjusted for fat mass expressed as percentage of body weight (%FM), was elevated on Day 1 compared with healthy subjects (1.82 [3.85] versus 0.32 [0.72] ng%/ml, p = 0.008), but decreased significantly until Day 7 (1.46 [3.77] ng%/ml, p = 0.015 versus Day 1). On Day 7, sTNF-R55 was, independently of %FM, correlated with the natural logarithm (LN) of leptin (r = 0.65, p = 0.041) and with plasma glucose (r = 0.81, p = 0.015). In addition, the dietary intake/REE ratio was not only inversely related with LN leptin ( − 0.74, p = 0.037), but also with sTNF-R55 (r = − 0.93, p = 0.001) on day seven. In conclusion, temporary disturbances in the energy balance were seen during an acute exacerbation of COPD, related to increased leptin concentrations as well as to the systemic inflammatory response. Evidence was found that the elevated leptin concentrations were in turn under control of the systemic inflammatory response, and, presumably, the high-dose systemic glucocorticosteroid treatment.
Trauma and the pyoderma gangrenosum of inflammatory bowel disease
Authors: S I Finkel, H D Janowitz
Journal: Gut (1981)

In five patients with inflammatory bowel disease (three with ulcerative colitis, two with Crohn9s disease), pyoderma gangrenosum developed on a lower extremity at the site of trauma. In these subjects, the pyoderma was not clearly correlated with disease activity.
Renal Cell Carcinoma (RCC) in Patients With End-Stage Renal Disease Exhibits Many Favourable Clinical, Pathologic, and Outcome Features Compared With RCC in the General Population
Authors: Yann Neuzillet, Xavier Tillou, Romain Mathieu, Jean-Alexandre Long, Marc Gigante, Philippe Paparel, Laura Poissonnier, Hervé Baumert, Bernard Escudier, Hervé Lang, Nathalie Rioux-Leclercq, Pierre Bigot, Jean-Christophe Bernhard, Laurence Albiges, Laurence Bastien, Jacques Petit, Fabien Saint, Franck Bruyere, Jean-Michel Boutin, Nicolas Brichart, Georges Karam, Julien Branchereau, Jean-Marie Ferriere, Hervé Wallerand, Sébastien Barbet, Hicham Elkentaoui, Jacques Hubert, Benoit Feuillu, Pierre-Etienne Theveniaud, Arnauld Villers, Laurent Zini, Aurélien Descazeaux, Morgan Roupret, Benoit Barrou, Karim Fehri, Thierry Lebret, Jacques Tostain, Jean-Etienne Terrier, Nicolas Terrier, Lucille Martin, Fabrice Dugardin, Ismaël Galliot, Frédéric Staerman, Marie-Dominique Azemar, Jacques Irani, Baptiste Tisserand, Marc-Olivier Timsit, Federico Sallusto, Pascal Rischmann, Laurent Guy, Antoine Valeri, Charles Deruelle, Abdel-Rahmène Azzouzi, Denis Chautard, Arnaud Mejean, Laurent Salomon, Jérôme Rigaud, Christian Pfister, Michel Soulié, François Kleinclauss, Lionel Badet, Jean-Jacques Patard
Journal: European Urology (2011)
Experimental Trichophyton infection of intact human skin
Authors: GURMOHAN SINGH
Journal: British Journal of Dermatology (1973)

A simple new method of producing experimental Trichophyton rubrum infection in man is discussed. A suspension of fresh culture using a granular colony was applied under occlusion on areas of skin. Occlusion was removed after 5 days and a semi‐occlusive dressing applied. It was possible to induce typical ringed or discoid lesions, which could persist for a long time if semi‐occlusive dressings were continuously applied.
Data selection and treatment of chemicals tested for genotoxicity and carcinogenicity.
Authors: N Loprieno, G Boncristiani, G Loprieno, M Tesoro
Journal: Environmental Health Perspectives (1991)

A database containing qualitative and quantitative results of experimental studies in the fields of genotoxicity and carcinogenicity has been developed. By analyzing results of the studies performed by the U.S. National Toxicology Program, or by a similar program developed in Japan, or reported in the scientific literature, as well performed by private organizations, information has been collected relating to 3389 chemicals, identified by their CAS number. The studies considered for the database include three genotoxicity/mutagenicity short-term test (STTs), namely, two in vitro (Salmonella, gene mutation assay, and mammalian cells/human lymphocytes chromosome aberration assay) and one in vivo, the rodent bone marrow micronucleus assay. To investigate the possible predictive value of these STT assays for carcinogenicity, the results of animal long-term bioassays have also been collected. We have re-evaluated all the genotoxicity studies and the majority of those cases studied in different laboratories with contrasting results has been resolved; a small proportion of questionable cases is, however, still present in the database. In total, 2898 (85.5%) of the chemicals have been tested in the Salmonella assay; 1399 (41.3%) have been tested in the in vitro chromosome aberration assay; 319 (9.4%) have been tested in the in vivo rodent bone marrow cell micronucleus assay; 716 (21.2%) of the chemicals have been tested in the in vivo animal long-term bioassay. For 1118 chemicals tested in the Salmonella assay, 30,650 quantitative studies have been included in the database, thus allowing a possible classification of mutagenic chemicals according to their mutagenic potency.(ABSTRACT TRUNCATED AT 250 WORDS)
Strengthening Driver Licensing Systems for Teenaged Drivers
Authors: Anne T. McCartt, Eric R. Teoh
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angiotensin II antagonist improves the hemodynamics and renal functions in the development of congestive heart failure
Authors: Yukiharu Maeda, Atsuyuki Wada, Takayoshi Tsutamoto, Daisuke Fukai, Keiko Maeda, Masato Ohnishi, Tomoko Hisanaga, Masahiko Kinoshita
Journal: Journal of the American College of Cardiology (1996)
The Effect on State Hospitalization of a Community Mental Health/Mental Retardation Center
Authors: JACK A. WOLFORD, JOHN HITCHCOCK, DAVID L. ELLISON, ANNE C. SONIS, FRED SMITH
Journal: American Journal of Psychiatry (1972)

The authors used comparative rates of slate hospitalization to measure the effect of their mental health/mental retardation center. Census tracts from their catchment area were matched with census tracts from an area that does not have such a center but that is served by the same state hospital. Lower rates of admissions to the state hospital and decreased chronic hospitalization were found in the catchment area population, and the center's activities were found to be related to these changes.
Idiopathic Hypertrophic Subaortic Stenosis: II. Operative Treatment and the Results of Pre- and Postoperative Hemodynamic Evaluations
Authors: ANDREW G. MORROW, COSTAS T. LAMBREW, EUGENE BRAUNWALD
Journal: Circulation (1964)

In 10 of 64 patients with IHSS, operations designed to relieve obstruction were performed. The pertinent preoperative clinical and hemodynamic findings in these patients, the operative methods employed, and the results of operation are presented in the present report. Eight of the patients were males, 2 were females, and at the time of operation their ages ranged from 10 to 54 years. All of the patients were symptomatic and all but 2 were in functional classes III and IV. In each patient left heart catheterization proved the presence of left ventricular outflow obstruction and the peak systolic gradients between the left ventricle and a systemic artery ranged from 68 to 175 mm. Hg (average 110 mm. Hg). The effective orifice areas ranged from 0.44 to 0.99 cm. 2 (average 0.61 cm. 2 ). Pulmonary hypertension was present in 2 patients. In 5 patients simple left ventriculomyotomy was performed, and in the other 5 ventriculomyotomy was combined with resection of a portion of the hypertrophied interventricular septum. One patient, in whom operative pressure measurements indicated satisfactory relief of obstruction, died suddenly on the eighth postoperative day, apparently from arrhythmia. Complete heart block was produced in 2 patients, and these patients have implanted pacemakers. Seven of the 9 surviving patients have been followed for periods of 7 to 51 months, and each has had striking symptomatic improvement. Left heart catheterizations have been carried out postoperatively on one or more occasions in all 7 patients. In 6 no intraventricular pressure gradient was present at rest or during exercise, while in the remaining patient a peak gradient of 24 mm. Hg was evident. The pertinent clinical findings in these 10 patients, the operative methods utilized, and the results of their pre- and postoperative hemodynamic assessments are presented in detail. Consideration is also given to present concepts in the selection of patients for operation, and in the choice of operative techniques.
Enteric Intussusception Presenting as a Cystic Abdominal Tumour
Authors: I. W. MacPhee
Journal: BMJ (1950)

Enteric Intussusception Presenting as a Cystic Abdominal TumourThe protean manifestations of acute abdominal emergencies are only too well known to the surgeon, and the following case is recorded not merely to demonstrate unusual clinical findings in such a condition but to show how one can be misled in their interpretation.The rarities in medicine are sometimes self-evident if one is acquainted with the condi- tion, but the mistakes in the diagnosis of the commonplace are often due to a wrong interpretation of the clinical findings, even after a careful examination.
A good read
Authors: Fiona Godlee
Journal: BMJ (2006)

If you're looking for a couple of slim volumes to read on your travels this summer, look no further. Here are two books to divert, improve, and inform. Firstly, Testing Treatments by Imogen Evans, Hazel Thornton, and Iain Chalmers is, according to our reviewer Ike Iheanacho, “a terrific little book” (p 1516). Its premise is that “knowledgeable ignorance” is something to aspire to. We should embrace uncertainty and stop feeling that we need to pretend that we know all the answers. Instead, say the authors, we should be rigorously questioning whether what we and others do is truly effective, since logic and good intentions are not enough. Sure …
Screening and Health Fairs-Reply
Authors: Donald M. Berwick
Journal: JAMA (1986)

In Reply.—  The National Health Screening Council for Volunteer Organizations Inc has a well-deserved reputation for integrity, professionalism, energy, and self-discipline, and I owe its staff a debt of gratitude for the assistance they offered during my research. Although my conclusion is that screening in health fairs is excessive at present, it would be an error to interpret this research as a general indictment of health fairs. On the contrary, I share Dr Perry's view that health fairs may be effective vehicles for health education and promotion, and I urge further research, in cooperation with NHSCVO and other health fair sponsors, to help health fairs reach their full potential.
Effects of Alcohol Ingestion on Estrogens in Postmenopausal Women
Authors: Elizabeth S. Ginsburg
Journal: JAMA (1996)

<h3>Objective.</h3> —To determine if moderate alcohol drinking increases circulating estradiol levels in postmenopausal women who are taking estrogen replacement. <h3>Design.</h3> —Randomized, double-blind, placebo-controlled crossover study of the effects of alcohol ingestion on plasma estradiol and estrone. <h3>Setting.</h3> —Inpatient Clinical Research Center. <h3>Participants.</h3> —Twelve healthy postmenopausal women receiving oral estrogen (estradiol, 1 mg/day) and progestin (medroxyprogesterone acetate) replacement therapy were compared with 12 postmenopausal women who were not using estrogen replacement therapy (ERT). <h3>Intervention.</h3> —Each group drank alcohol (0.7 g/kg) and an isoenergetic (isocaloric) placebo (randomized sequence) on consecutive days. Women who were taking ERT were studied during the estrogen-only portion of their replacement cycle, and estrogen was administered each evening at 2100 hours. <h3>Main Outcome Measure.</h3> —The impact of alcohol ingestion on plasma estradiol and estrone levels. <h3>Results.</h3> —Alcohol ingestion lead to a 3-fold increase in circulating estradiol in women on ERT; however, alcohol did not change estradiol significantly in control women who were not on ERT. In women using ERT, estradiol levels increased from 297 to 973 pmol/L (81 to 265 pg/mL) within 50 minutes (<i>P</i>&lt;.001) during the ascending limb of the blood alcohol curve and remained significantly above baseline for 5 hours (<i>P</i>&lt;.001). No significant increase in circulating estrone was detected in either group. However, estrone levels decreased after alcohol and placebo in women on ERT (<i>P</i>&lt;.05). Blood alcohol levels did not differ significantly in women who used ERT and those who did not. Peak blood alcohol levels of 21 mmol/L were attained in each of the 2 groups within 50 to 60 minutes after drinking began. Changes in estradiol were significantly correlated with changes in blood alcohol levels on both the ascending (<i>P</i>&lt;.001) and descending (<i>P</i>&lt;.001) limb of the blood alcohol curve. <h3>Conclusions.</h3> —Acute alcohol ingestion may lead to significant and sustained elevations in circulating estradiol to levels 300% higher than those targeted in clinical use of ERT. Potential health risks and benefits of the interactions between acute alcohol ingestion and ERT should be further evaluated.