tbuckley/cabot-search huggingface dataset:
Abstract 1298: Effects of carfilzomib (CFZ) on pharmacokinetics of midazolam (MDZ) in subjects with solid tumors
Authors: Suzanne F. Jones, Johanna C. Bendell, Howard A. Burris, Marcy K. Vallone, Alvin F. Wong, Jeffrey R. Infante
Journal: Cancer Research (2011)

Abstract Introduction: CFZ is a novel, highly selective epoxyketone proteasome inhibitor that has demonstrated durable single-agent antitumor activity in patients (pts) with relapsed or refractory myeloma and solid tumors. PX-171-008 was an open-label, Phase 1b, non-randomized, fixed sequence study to determine the effect of CFZ on the PK of MDZ, a sensitive substrate of human cytochrome P450 3A4. Methods: During Period 1, pts received a single, 2 mg oral dose of MDZ. In Period 2 the same pts received 27 mg/m2 CFZ IV push on Days 1, 2, 8, 9, 15, and 16 of a single 28-day cycle. Oral MDZ was given immediately following CFZ on Days 1 and 16. The primary endpoint was to evaluate the PK of MDZ in the presence or absence of CFZ. The extent of CYP 3A4/5 interaction was evaluated based on fold-change in AUC for MDZ. ICH Guideline for extent of interaction: Strong = &amp;gt; 5-fold change, Moderate 2-5-fold, Weak = 1.25-2. Safety was evaluated by assessment of adverse events (AEs), clinical laboratory tests, physical exams, vital signs, and an ECG. Results: 18 pts (12 female, 6 male) were enrolled. Of these, 12 completed and were eligible for full PK analysis, 5 terminated prior to receiving all 6 doses of CFZ and were included only in the day 1 PK analysis, and 1 discontinued prior to receiving any doses of CFZ and was excluded from all PK and safety analysis. All 17 pts included in the PK analysis had significant exposure to CFZ on Day 1. The results suggest that CFZ does not clinically interact with oral MDZ (not even qualifying as a weak inhibitor of CYP3A4). PK parameters are summarized below. All pts experienced at least 1 AE. The most common were fatigue (52.9%), nausea (52.9%), dyspnea (35.3%), anxiety (23.5%), headache (23.5%), and vomiting (23.5%). AEs were primarily Grade 1/2 in severity and were similar to the safety profile in other CFZ studies. Conclusions: Administration of CFZ did not result in a clinically significant impact on the PK of MDZ. The observed safety profiles were similar to those previously reported for each drug. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1298. doi:10.1158/1538-7445.AM2011-1298
Cause and age at death in a prospective study of 100 patients with rheumatoid arthritis.
Authors: J J Rasker, J A Cosh
Journal: Annals of the Rheumatic Diseases (1981)

A series of 100 patients with rheumatoid arthritis (RA), first seen in the early months of their disease, have now been followed up for 18 years, and 43 have died. Rheumatoid disease directly caused death in 9, and the disease or its treatment contributed to death in 7. These 16 patients were younger at onset and younger at death than the 27 in whom death was unrelated to RA. Of clinical features noted 1 year after the onset of RA a worse ARA grading and a worse functional capacity were already evident in those 16 patients. Conversely, the 57 still surviving had a better ARA grading and a better functional capacity after 1 year than those who died. The survivors were also significantly younger than the rest at the onset of RA. The death rate throughout the follow-up period was higher in the patients graded as 9classical9 than those graded as 9definite9 RA after 1 year of disease.
Ultrastructural Aspects of Disease
Authors: Earl P. Benditt
Journal: JAMA (1967)

The main purpose of this book is to depict the changes in fine structure found in disease. This difficult aim Dr. King has attempted within the remarkably short confines of 279 pages, including 97 plates. The 308 illustrations making up the plates comprise contributions from 173 investigators. In addition to an introduction relating some of the concepts of modern biology and pathology, there are 15 chapters. The first three considers cell structure, cell injury, and cell response; the remaining 12 cover a corresponding number of systems. Each chapter has an introductory series of statements about general pathologic processes or specific diseases, followed by several plates illustrating some of these changes.  It is plainly impossible to cover comprehensively, in so little space, such a complex and heterogeneous mass of material. The result is a staccato presentation of some highlights and of some important concepts of disease. Of necessity, many of the
Cross-National Study of Diagnosis of the Mental Disorders: Some Comparisons of Diagnostic Criteria from the First Investigation
Authors: BARRY J. GURLAND, JOSEPH L. FLEISS, JOHN E. COOPER, ROBERT E. KENDELL, ROBERT SIMON
Journal: American Journal of Psychiatry (1969)

A sample of patients from a New York and a London mental hospital were compared so as to point out any differences between the two hospitals in the criteria associated with a hospital diagnosis of either schizophrenia or affective illness. Groups of patients with similar psychopathology tended to receive similar diagnoses, but a subgroup with marked mood disturbance and little disorganization tended to be called schizophrenic by the New York hospital staff and affectively ill by the London hospital staff.
Guideline: Dementia Drugs’ Benefits Uncertain
Authors: Rebecca Voelker
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UN condemns female circumcision
Authors: J. Hamilton
Journal: BMJ (1997)

The United Nations has called for an end to ritual female genital mutilation, a practice to which an estimated 130 million girls and women worldwide have been subjected.

The heads of the WHO, Unicef, and the United Nations Population Fund published a statement last week calling for an international effort to bring about a “major decline” within 10 years in what they …
PREMARITAL EXAMINATION LAWS IN THE UNITED STATES
Authors: GEORGE F. FORSTER
Journal: JAMA (1942)

With the passage of six new premarital examination laws by 1941 legislatures, thirty states now require that a certificate of examination be presented before marriage licenses may be issued. All of these measures have one objective in common; namely, prevention of the spread of syphilitic infections through the vehicle of marriage. A number of them are aimed also at curbing other venereal diseases, and a few undertake to reduce the incidence of tuberculosis or mental disorders as well. Most of them, however, resemble Connecticut's successful law, adopted by that state in 1935, to the extent of requiring a blood test for syphilis. The diversity of legal and administrative details which characterizes the premarital laws of the various states is not surprising when one considers their separate origin in as many legislatures. In some instances original bills had to be modified to satisfy local opposition. Several states had early but ineffective
Biological Rhythms in Clinical Practice
Authors: Panayotis G. Iatridis
Journal: JAMA (1990)

<i>Biological Rhythms in Clinical Practice</i>is an interesting book that deals with time-related variations in human biology and the effects of these regular repetitions on a number of processes in human behavior, physiology, and pathology. It is indicated that the study and awareness of the rhythmic biological processes can allow the practicing physician to enhance the patient's response to treatment and the community to improve the well-being and productivity of a large group of its citizens. Although the authors describe and emphasize circadian rhythms (24-hour periods), they also present circannual (seasonal period) and ultradian (short period) rhythms. An effort has been made to explain the endogenous components and<i>Zeitgebers</i>(time-givers) and the exogenous components that can alter or influence biological rhythms. Chronopharmacology, "time-dependent variations in pharmacology," is well presented, and its implications in pharmacokinetics and pharmacodynamics in health and disease are given in some detail. The importance of biological rhythms
Abstract 2729: Suppression of hematogenous metastasis by mouse and murine/human chimeric anti-Aggrus/podoplanin antibodies
Authors: Satoshi Takagi, Naoya Fujita
Journal: Cancer Research (2012)

Abstract Tumor cell-induced platelet aggregation has been known to facilitate hematogenous metastasis by increasing the arrest of tumor cell emboli in the microvasculature. We have previously established metastatic variants of cancer cells and identified Aggrus (also known as podoplanin, T1alpha, gp36) as a platelet aggregation-inducing factor expressed on the surface of highly metastatic variants. Aggrus, a type-I transmembrane sialomucin-like glycoprotein, induced platelet activation via interaction with one of its counter receptor CLEC-2 (C-type lectin-like receptor 2) expressed on platelet surface. Thus, Aggrus-induced platelet aggregation did not require any plasma components. Moreover, Aggrus has been shown to be up-regulated in many different types of cancers and to be associated with poor outcome. Thus, Aggrus must be a useful cancer specific antigen in addition to a useful therapeutic target for developing hematogenous metastasis inhibitors. In this study, we established an anti-human Aggrus monoclonal antibody, designated as P2-0, and investigated its potential as a hematogenous metastasis inhibitor. We observed that P2-0 antibody could inhibit Aggrus-CLEC-2 interaction detected by in vitro competition assay and could suppress Aggrus-induced platelet aggregation in a concentration-dependent manner. Moreover, P2-0 antibody decreased the number of Aggrus-mediated pulmonary metastatic foci in in vivo experimental mouse model. We then cloned complementarity-determining region of P2-0 antibody and generated murine/human chimeric P2-0 antibody. We revealed that chimeric P2-0 antibody retained Aggrus-neutralizing activity and inhibited the experimental pulmonary metastasis of cancer cells that endogenously expressed Aggrus on their surface. These data indicate that P2-0 antibody and its chimeric antibody are useful as inhibitors of Aggrus-mediated hematogenous metastasis and expected to be applied for the clinical examination of Aggrus-targeted cancer therapy. This study was supported in part by a grant from the Program for the Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation, Japan. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2729. doi:1538-7445.AM2012-2729
ACUTE PUERPERAL INVERSION OF THE UTERUS
Authors: C. S. L. Roberts
Journal: BMJ (1923)

MARCH~3_,123 5 beginning (so long as haemoptysis has ceased)-will get their best chance at Davos, or at some other Alpine station with the climatic conditions of Davos-namely, pure, still, dry, cold, diaphanous, and diathermic air.Unsuitable early cases for the high Alps are: acute cases, nervous, irritable people, elderly people, chilly people, most laryngeal cases, and thlose with much emphysema, with heart diease, or with albuminuria.In choosing other foreign climates than Switzerland we must not forget that Australia, New Zealand, the Cape, Canada, and the United States no longer admit cases of active tuberculosis.This leaves us a rather narrow choice.Sea voyages are by no means a safe prescription, particularly if they cross the tropics The Riviera does not appear to give better results than can be obtained in England.Egypt at the present moment does not suggest itself as desirable.Las Palmas in Grand Canary has given good results; its climate should not be confused with the quite different climates of Orotava in Teneriffe and of Madeira.South-eastern Spain and the desert behind Algiers are still advised.In sending phthisical patients long distances their travelling powers must be considered, as well as the luxuries of travel and accommodation which they are prepared to allow themselves; also, and very important, the medical skill available in the health resort decided on.In the light of home sanatorium results all these localities will require consideration. CONCLUSION.To conclude, I would like to leave it clear that, from the foregoing comparison of open-air results, I claim to draw no final inference.They are too few, the definitions of " early " are too various, and the absence of uniform finding of tubercle bacilli renders the diagnoses too uncertain.What I do claimn, and claim 8trongly, iw that they con8tstite a case for iimmediate inve8ti.gation.
FIRST VALIDATION OF ADJUNCTIVE CILOSTAZOL LOADING EFFECT AND DOSAGE ON PLATELET INHIBITION: RESULTS OF THE ACCEL-LOADING STUDY
Authors: Young-Hoon Jeong, In-Suk Kim, Yongwhi Park, Jeong Rang Park, Seok-Jae Hwang, Choong Hwan Kwak, Jin-Yong Hwang
Journal: Journal of the American College of Cardiology (2011)
Eye Pathology: An Atlas and Text
Authors: Jay Ira Perlman
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination
Authors: Xuan-Hung Nguyen, Philipp A. Lang, Karl S. Lang, Dieter Adam, Gulnar Fattakhova, Niko Föger, Mohammad Azhar Kamal, Patricia Prilla, Sabine Mathieu, Christina Wagner, Tak Mak, Andrew C. Chan, Kyeong-Hee Lee
Journal: Blood (2011)
Sarcoma of Intestines.
Authors: C. Van Zwalenburg
Journal: JAMA (1905)

Riverside, Cal., Dec. 30, 1904. <h3>To the Editor:</h3> —Five years ago I removed from Harold S. a small round-celled sarcoma with several inches of intestine, from which it originated. The case was reported inTheJournal, March 9, 1901, under the title "Sarcoma of the Intestines with Table of Fifteen Cases of Resection." A few weeks ago I visited this patient, now as well developed and as robust a boy of 10 as one often sees. I found no evidence of trouble about his abdomen or lymphatics, nor anywhere, in fact. The only effect traceable to the operation was a little more frequency of bowel movements than normal, but this never amounted to a diarrhea; usually there were one or two movements a day. In view of the fact that although a number of enlarged mesenteric glands were of necessity left in the abdomen and that there was no return
Characterization of plasma cytokines in an infant population cohort of challenge‐proven food allergy
Authors: T. D. Dang, M. L. K. Tang, J. J. Koplin, P. V. Licciardi, J. K. Eckert, T. Tan, L. C. Gurrin, A.‐L. Ponsonby, S. C. Dharmage, K. J. Allen
Journal: Allergy (2013)

Abstract Background Sensitization to food allergens indicates the production of food‐specific I g E ; however, sensitization is not a definite indicator of allergic reaction upon ingestion (N Engl J Med, 344, 2001, 30: J Allergy Clin Immunol, 120, 2007, 491). Currently, food challenge is the best approach to identify the presence or absence of allergy. While 95% positive predictive values ( PPV s) thresholds for s I g E can assist with identifying increased likelihood of allergy among those who are sensitized, there are no specific biological markers that differentiate between allergic and sensitized individuals. Objectives To determine whether plasma serum cytokine profiles predict (i) sensitization to peanut and egg and (ii) food allergy among sensitized infants. Methods Peanut‐sensitized (PT) and egg‐sensitized 14‐month‐old infants and nonsensitized controls enrolled in HealthNuts, a population‐based study of food allergy, underwent an oral food challenge ( OFC ). Blood was collected within 1 h after OFC. Serum levels of Th1, Th2 and regulatory cytokines were determined in allergic ( n = 79), sensitized ( n = 40) and nonsensitized, nonallergic ( n = 37) infants by multiplex assay. Results Food‐sensitized infants had significantly higher plasma IL ‐4, IL ‐13, IL ‐12p70 and lower IL ‐10 levels compared to nonsensitized infants. IL ‐10 and IL ‐6 levels were significantly higher in sensitized compared with allergic infants. Egg‐allergic infants had significantly higher IL ‐13 and IL ‐12p70 levels compared to peanut‐allergic (PA) infants. Conclusion Levels of T h2‐related cytokines in plasma are higher in food‐sensitized infants, irrespective of clinical food allergy status. In contrast, IL ‐10 levels appear to predict food allergy among sensitized infants. Differences in IL ‐13 and IL ‐12p70 between egg‐ and peanut‐allergic infants could help explain the different resolution rates of the allergies.
Intermediate care: policy before evidence
Authors: Norman J Vetter
Journal: BMJ (2005)

Intermediate care had the characteristics of much new national policy when it was launched; it lacked definition, had no evidence for its effectiveness, and was aimed at solving a problem that it was unlikely to impact on—in this case overcrowding in hospitals. It is therefore good to see new evidence on the effectiveness of a service that fits under the umbrella term “intermediate care” compared with care in a district general hospital department for the care of elderly people, as reported by Green et al.1

The relation between older people and hospitals is a complex one. A suspicion among several …
Chronic Hepatitis As a First Manifestation of Wilson's Disease
Authors: IRMIN STERNLIEB
Journal: Annals of Internal Medicine (1972)

In four males and three females, from 12 to 28 years of age, chronic hepatitis was diagnosed because of manifestations indistinguishable from those generally associated with this disease. From 3 months to 4½ years after the onset of hepatic illness, persistence of the hepatic disorder for 4 years in one boy, a diagnosis of Wilson's disease in one girl's sibling, the development of neurologic symptoms in four of these patients, and the accidental discovery of Kayser-Fleischer rings in a man led to the suspicion of Wilson's disease in each of the seven patients. Although copper toxicity is etiologic in probably no more than 5% of patients with chronic hepatitis, it is susceptible to specific and effective pharmacologic therapy, unlike most other forms of hepatitis. Consequently, the disease should be borne in mind and the concentration of ceruloplasmin in serum measured in every child or young adult under 30 years of age with idiopathic chronic hepatitis.
Alcohol-Induced Genital Pain in Recurrent Hodgkin's Disease
Authors: William B. Ershler
Journal: JAMA (1979)

THE ASSOCIATION between alcohol-induced pain and Hodgkin's disease was first noted by Hoster<sup>1</sup>in 1950. Several series<sup>2-7</sup>have confirmed this association; however, pruritus, paresthesia, cough, and general malaise have also been reported.<sup>3</sup>Patients with other malignant<sup>5</sup>and nonmalignant conditions<sup>5,6</sup>have been described to have alcohol-induced pain. We examined a patient whose complaint of alcohol-induced pain in the labia majora led to the diagnosis of recurrent Hodgkin's disease. <h3>Report of a Case</h3> A 34-year-old woman was admitted to the hospital because of genital pain. Eight years before admission, an intermittent pain in the right hip developed, which characteristically was induced by the ingestion of alcohol, even in small quantities. She had anterior cervical lymphadenopathy, and a biopsy specimen demonstrated nodular sclerosing Hodgkin's disease. Lymphangiogram demonstrated intra-abdominal lymph node enlargement, and bone roentgenogram findings were consistent with findings of Hodgkin's disease in the right side of the
Dermoscopy of facial nonpigmented actinic keratosis
Authors: I. Zalaudek, J. Giacomel, G. Argenziano, R. Hofmann-Wellenhof, T. Micantonio, A. Di Stefani, M. Oliviero, H. Rabinovitz, H.P. Soyer, K. Peris
Journal: British Journal of Dermatology (2006)

Background The accuracy of clinical diagnosis of nonpigmented, facial actinic keratosis (AK) is often suboptimal, even for experienced clinicians. Objectives To investigate the dermoscopic features of nonpigmented AK located on the head/neck that may assist the clinical diagnosis. Methods Forty‐one nonpigmented AKs on facial sites were examined by dermoscopy for any consistent underlying features. Lesions were gathered from skin cancer centres in Australia, Austria, Italy and the U.S.A. All cases were diagnosed histopathologically. Results Four essential dermoscopic features were observed in facial AK: (i) erythema, revealing a marked pink‐to‐red 'pseudonetwork' surrounding the hair follicles (95%); (ii) white‐to‐yellow surface scale (85%); (iii) fine, linear‐wavy vessels surrounding the hair follicles (81%); and (vi) hair follicle openings filled with yellowish keratotic plugs (66%) and/or surrounded by a white halo (100%). These features combined, in 95% of cases, to produce a peculiar 'strawberry' appearance. Conclusions A dermoscopic model of 'strawberry' pattern is presented, which may prove helpful in the in vivo diagnosis of nonpigmented, facial AK. A limitation of this study is the lack of testing of the specificity of the described dermoscopic criteria in differentiating nonpigmented AKs from other nonpigmented skin lesions at this site.