Disseminated Intravascular Coagulation Syndrome with Metastatic Melanoma: Remission After Treatment with 5-(3,3-Dimethyl-1-Triazeno) Imidazole-4-Carboxamide (DTIC)
Authors: GEORGE P. SUSENS
Journal: Annals of Internal Medicine (1976)

Letters1 February 1976Disseminated Intravascular Coagulation Syndrome with Metastatic Melanoma: Remission After Treatment with 5-(3,3-Dimethyl-1-Triazeno) Imidazole-4-Carboxamide (DTIC)GEORGE P. SUSENS, M.D., CHARLES HENDRICKSON, M.D., DEBORAH A. BARTO, M.D., BRUCE J. SAMS, M.D.GEORGE P. SUSENS, M.D.Search for more papers by this author, CHARLES HENDRICKSON, M.D.Search for more papers by this author, DEBORAH A. BARTO, M.D.Search for more papers by this author, BRUCE J. SAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-2-175 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe have observed a dramatic response of melanoma with disseminated intravascular coagulation to a chemotherapeutic agent, 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC) (1).A 67-year-old white man presented with cough of 2 months' duration, 8.2-kg weight loss, anorexia, and fatigue. He was alert and pale, with multiple ecchymoses on the arms. Chest X ray showed a small coin lesion in the lower lobe of the left lung. His hematocrit value was 34%; leukocyte count, 3600/mm3; and erythrocyte sedimentation rate, 64 mm/h. He was admitted to the hospital. The next morning his hematocrit value was 30%; platelet count, 7000/mm3; reticulocytes, 2.7%. Helmet cells were...References1. GOLDSMITHFRIEDMANCARTER MMS: 5-(3,3-Dimethy-1-triazeno) imidazole-4-carbozamide (DTIC, DIC) NSC-45388. Bethesda, Division of Cancer Treatment, National Cancer Institute, August 1972 Google Scholar2. BOWIEOWEN EC: Symposium on the diagnosis and treatment of intravascular coagulation-fibrinolysis (ICF) syndrome, with special emphasis on this syndrome in patients with cancer. Mayo Clin Proc 49:635-679, 1974 MedlineGoogle Scholar3. MCKAY D: Progress in disseminated intravascular coagulation. II. Calif Med 111:279-290, 1969 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE P. SUSENS, M.D.; CHARLES HENDRICKSON, M.D.; DEBORAH A. BARTO, M.D.; BRUCE J. SAMS, M.D.Affiliations: Department of Internal Medicine Kaiser-Permanente Medical Center San Francisco, California 94115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisseminated intravascular coagulation and melanoma: a novel case occurring in metastatic melanoma with BRAF and NRAS mutations and systematic reviewVemurafenib-Induced Disseminated Intravascular Coagulation in Metastatic MelanomaHaemorrhage due to proteolysis of FXIII and hyperfibrinolysis under vemurafenib treatment of metastatic melanomaMelanoma-associated disseminated intravascular coagulationSuccessful Treatment of Acute Disseminated Intravascular Coagulation in a Patient with Metastatic MelanomaHematologic manifestations of malignancyCase 26-1984 1 February 1976Volume 84, Issue 2Page: 175-176KeywordsDisseminated intravascular coagulationFatigueHematocritLesionsLungsMelanomaPlateletsReticulocytesThoraxWeight loss ePublished: 1 December 2008 Issue Published: 1 February 1976 PDF downloadLoading ...