tbuckley/cabot-search huggingface dataset:
The Fifteen Years of Discoveries That Shaped Molecular Electrophysiology
Authors: Silvia G. Priori
Journal: Circulation Research (2010)

Abstract: This article serves as an introductory overview to a thematic review series that will present the latest advancements in the field of inherited arrhythmias. This area of cardiac electrophysiology started approximately 15 years ago thanks to the contribution of Mark Keating and coworkers, who discovered the molecular basis of long QT syndrome. The field rapidly expanded when clinicians, molecular biologists, geneticists, and cellular electrophysiologists, who undertook an impressive collaborative effort to clarify the genetic basis of “cardiac channelopathies.” As a result of this hard work, the paradigms for diagnosis and management of patients with inherited arrhythmogenic diseases were substantially modified, demonstrating once more the value of “translational research.” As more and more genes have been implicated in the genesis of inherited arrhythmias, we keep broadening our understanding of the complexity of ion channels and their multifaceted regulatory processes. Despite the fact that several discoveries have already been made, the field is facing new challenges that are attracting young investigators who share with the pioneers the ambitious goal of finding new therapies and even a cure for these conditions.
FDG PET/CT Detection of Intussusception Caused by Lymphoma in a Pediatric Patient
Authors: Hye Jin Kang, Volkan Beylergil, Anita P. Price, Sara J. Abramson, Jorge A. Carrasquillo
Journal: Clinical Nuclear Medicine (2013)

A previously healthy 9-year-old boy presented to an outside hospital with a history of abdominal pain and vomiting. An abdominal x-ray was unremarkable. A CT of the abdomen and pelvis performed to evaluate possible obstruction after weight loss and vomiting over a 3-week period demonstrated a large retroperitoneal mass. Laparoscopic biopsy showed diffuse large B-cell lymphoma. FDG PET/CT was performed for staging. An ileocolic intussusception was identified on the PET/CT. The intussusception was successfully managed with medical treatment. We present FDG PET/CT findings in intussusception with non-Hodgkin lymphoma as the lead point in a pediatric patient.
Reducing versus Discontinuing Erythropoietin at High Hemoglobin Levels
Authors: Daniel E. Weiner, Dana C. Miskulin, Kimberly Seefeld, Vladimir Ladik, Philip G. Zager, Ajay K. Singh, H. Keith Johnson, Klemens B. Meyer
Journal: Journal of the American Society of Nephrology (2007)

A 2006 change in Medicare policy allowed reimbursement for erythropoietin (EPO) in dialysis patients whose most recent hemoglobin exceeded 13 g/dl. We investigated the effects of a change in dosing algorithm implemented in response to this policy, in which EPO dosages were reduced instead of temporarily discontinued for hemoglobin levels ≥13 g/dl. Among 1688 individuals in 18 hemodialysis units, the reduction protocol resulted in more hemoglobin levels ≥13 g/dl (P < 0.0001), fewer levels between 11 and 12.9 g/dl (P ≤ 0.004), no difference in the proportion of levels <11 g/dl, and more EPO administered per session (P < 0.0001) than the discontinuation protocol. In view of the expense of erythropoiesis stimulating agents and the uncertainty of the safety of using EPO to achieve high hemoglobin targets, this study suggests that discontinuation, rather than reduction, of EPO treatment is appropriate when hemoglobin reaches 13 g/dl in hemodialysis patients.
Elemental analysis of renal slices by proton-induced X-ray emission.
Authors: T Lowe, Q Chen, Q Fernando, R Keith, A J Gandolfi
Journal: Environmental Health Perspectives (1993)

We optimized proton-induced X-ray emission (PIXE) for tissue analysis in a toxicity-disposition study. We used cultured rabbit renal slices as the biological system to demonstrate the use of PIXE analysis. The renal slices were exposed to HgCl2, CdCl2, K2Cr2O7, or NaAsO2 alone or in a mixture. The PIXE analysis provides information on concentrations of elements above atomic number 11, and it is the only analytical technique that can determine 20-30 elements nondestructively in a single, small sample (approximately 5 mg) with detection limits of 1-5 ppm (dry weight). The renal slices are thin targets that yield X-ray emission spectra with low backgrounds and high elemental sensitivities. The nondestructive nature of PIXE and the ability to simultaneously measure uptake of multiple metals and endogenous elements are unique to this methodology.
First team of overseas surgeons arrives in England
Authors: W. Moore
Journal: BMJ (2002)

Health secretary Alan Milburn has brushed aside concerns raised by the Royal College of Surgeons that overseas doctors being flown to England to reduce NHS waiting lists could threaten patient safety.

As Mr Milburn met some of the first consultant surgeons arriving to take part in the governmentinitiative last week he said, “These are top class European doctors who will do a first class job for NHS patients, and in the process they should help relieve the pressure on existing NHS doctors.”

A spokesman for the Department of Health later made clear that the college would have no veto over the selection of overseas surgeons in local schemes. He said, “No …
1098-102 C-reactive protein on admission is an independent predictor of one-year mortality in patients with acute myocardial infarction: A prospective study
Authors: Mahmoud Suleiman, Riad Mahamid, Rania Khatib, Walter Markiewicz, Oren Zinder, Michael Kapeliovich, Yishai Levy, Haim Hammerman, Doron Aronson
Journal: Journal of the American College of Cardiology (2004)
Molecular phylogeny and evolution of unique mud-using territorial behavior in ocypodid crabs (Crustacea: Brachyura: Ocypodidae)
Authors: J. Kitaura, K. Wada, M. Nishida
Journal: Molecular Biology and Evolution (1998)

Among crabs of the family Ocypodidae, Ilyoplax has been known to exhibit unique mud-using territorial behavior against neighbors, including neighbor burrow plugging, barricade building, and fence building. To assess the evolution of current behavioral forms observed in Ilyoplax, 1,416-bp nucleotide sequences from the mitochondrial 12S rRNA to 16S rRNA genes of 20 species, representing four recognized subfamilies of Ocypodidae, were analyzed. The resultant phylogenetic tree revealed the subfamily Dotillinae, including Ilyoplax, to be monophyletic, with a sister group relationship with subfamily Camptandriinae. These two subfamilies were branched after Ocypodinae, with Macrophthalminae being most basal. Species of Ilyoplax fell into three different Dotillinae lineages, indicating the genus to be polyphyletic. Crabs in two of the three lineages showed differential geographic distribution and body size. Phylogenetic analyses of behavioral characters demonstrated that mud-using techniques had evolved multiple times and sequentially. From their behavioral similarity and evolutionary occurrence, fence building is hypothesized to have evolved from barricade building, and the latter, from burrow plugging. This scenario also appeared reasonable with respect to behavioral trends observed in the field. The evolution of such territorial behavior is considered to be associated with ecological conditions such as burrow fidelity and substrate condition.
New Generation Left Ventricular Assist Device for End Stage Heart Failure Therapy: Ege University Experience
Authors: Yaprak Engin, Tahir Yağdı, Özlem Balcıoğlu, Çağatay Engin, Serkan Ertugay, Sanem Nalbantgil, İlyas Kultayev, Nurjhan Narymbetov, Mehdi Zoghi, Mustafa Özbaran
Journal: Journal of the American College of Cardiology (2013)
Prevention of type 2 diabetes
Authors: K M V. Narayan, B. A Bowman, M. E Engelgau
Journal: BMJ (2001)

Almost three decades ago the Finnish led the way for prevention of coronary heart disease by successfully implementing the community based North Karelia project.1 With the recent publication of their randomised controlled clinical trial of prevention of type 2 diabetes, Tuomilehto et al have now shown that effective lifestyle changes can prevent another major chronic disease of our time. 2 3

Type 2 diabetes has long been linked with behavioural and environmental factors such as overweight, physical inactivity, and dietary habits.4 The findings from the Finnish trial confirm this link. Major lifestyle changes resulting from industrialisation are contributing to a rapid rise in diabetes worldwide, but especially in industrialising countries. An estimated 135 million people worldwide had diagnosed diabetes in 1995, and this number is expected to rise to at least 300 million by 2025.4 Between 1995 and 2025 the number of people with diabetes will increase by 42% (from 51 to 72 million) in industrialised countries and by 170% (from 84 to 228 million) in industrialising countries.

Diabetes exerts a huge …
Food additives and hyperactivity
Authors: Andrew Kemp
Journal: BMJ (2008)

Evidence supports a trial period of eliminating colourings and preservatives from the diet

Whether preservatives and colourings cause or exacerbate hyperactive behaviours is an important question for many paediatricians and parents. A recent randomised placebo controlled trial in 297 children aged 3-9 years provides evidence of increased hyperactive behaviour after they ate a mixture of food colourings and a preservative (sodium benzoate).1 In contrast to many previous studies, the children were from the general population and did not have attention-deficit/hyperactivity disorder. The trial found an adverse effect of the mixture on behaviour as measured by a global hyperactivity aggregate score. The daily dose approximated that found in two 56 g bags of sweets.

In view of the potential importance of these findings, the European Food Safety Authority (EFSA) recently provided an opinion that takes other evidence into account. …
Internet-Based Education for Health Professionals
Authors: Rita Banzi, Ivan Moschetti, Lorenzo Moja
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acetate of Potash in Rheumatic Fever
Authors: J. R. Nicholson
Journal: BMJ (1857)

lowing are extracts from communications of successive later dates." July 16th, 1856.I am pleased to inform you that I am progressing very well.The liquor pepsiniw, quite agrees with ilae; especially in the form of mixture which you recommended, as I have a little acidity and flatulence.I do not make much, if any, im-ore water than the usual quantity; certainly not so much as I lhave taken of fluids.Specific gravity about 1030.
Computers in Patient Care
Authors: G. Octo Barnett
Journal: New England Journal of Medicine (1968)

IN most areas of medical care, adaptations in practice have kept pace with advances in knowledge about diseases and therapeutic procedures. However, one vital area of medical practice, information processing, has been badly neglected, and little progress has been made. The technology of data processing in dozens of other fields has been revolutionized by the computer in the last two or three decades. Yet few of these changes have made their way into the medical world — in particular into the hospital. Most information used by hospitals in patient care is written, often in illegible script on multi-part forms. The . . .
High-dose melphalan and peripheral blood stem cell transplantation for light-chain amyloidosis with cardiac involvement
Authors: Sumit Madan, Shaji K. Kumar, Angela Dispenzieri, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, David Dingli, S. Vincent Rajkumar, William J. Hogan, Nelson Leung, Martha Grogan, Morie A. Gertz
Journal: Blood (2011)
A CASE OF CARCINOMA OF THE PANCREAS.WITH NEGATIVE SO-CALLED PANCREATIC REACTION; CHOLECYSTENTEROSTOMY.
Authors: JOHN C. HANCOCK
Journal: JAMA (1906)

In a series of 53,000 cases of carcinoma collected from European institutions, in which careful postmortem records are kept, there were 226 cases of carcinoma of the pancreas, or 4.2 cases in every 1,000 cases of carcinoma of all organs. In the following case, in spite of repeated trials and a positive diagnosis, the so-called pancreatic reaction of Cammidge was negative. In the course of an exploratory laparotomy cholecystenterostomy was performed to relieve distress from absorption of bile and pain due to pressure of distention of the bile tract and accomplished the purpose. <h3>Patient.</h3> —D. A., farmer, 58 years old, married, born in England, residence Bloomington, Wis., was referred to me June 26, 1905, by Dr. J. M. Lewis of the same place. <h3>Family History,</h3> —Negative, except that his father died of "stomach trouble." <h3>Previous History.</h3> —In this the only conspicuous features are sciatic rheumatism, so-called, from time to time
Ranitidine and Cimetidine
Authors: David Jack, Robert N. Smith, Peter J. Wise
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 May 1984Ranitidine and CimetidineDAVID JACK, PH.D., ROBERT N. SMITH, M.D., PETER J. WISE, M.D.DAVID JACK, PH.D.Search for more papers by this author, ROBERT N. SMITH, M.D.Search for more papers by this author, PETER J. WISE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-5-768_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. McCarthy's conclusion in a recent editorial (1) that there appears to be no substantial difference between ranitidine and cimetidine conflicts with the opinions of others (2, 3) who also have recently reviewed the same evidence. The latter workers concluded that ranitidine is the preferred H2-antagonist for certain patients, because of its lack of antiandrogenic activity and lesser affinity for the hepatic P450-linked mixed-function oxygenase enzyme system (P450 enzyme). In our view, the difference of opinions arises from undue weight given by McCarthy to short papers and letters of doubtful scientific value or even of relevance to...References1. MCCARTHY D. Ranitidine or cimetidine [Editorial]. Ann Intern Med. 1983;99:551-3 LinkGoogle Scholar2. ZELDISFRIEDMANISSELBACHER JLK. Ranitidine: a new H2-receptor antagonist. N Engl J Med. 1983;309:1368-73 CrossrefMedlineGoogle Scholar3. STRUM W. Ranitidine. JAMA. 1983;250:1894-6 CrossrefMedlineGoogle Scholar4. JACKMITCHARDSMITH DMR. Influence of ranitidine on plasma metoprolol concentrations. Br Med J. 1983;287:1218. Google Scholar5. SORKINDARVEY ED. Review of cimetidine drug interactions. Drug Intell Clin Pharm. 1983;17:110-20. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID JACK, PH.D.; ROBERT N. SMITH, M.D.; PETER J. WISE, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1984Volume 100, Issue 5Page: 768-769KeywordsEnzymes ePublished: 1 December 2008 Issue Published: 1 May 1984 PDF downloadLoading ...
Abstract P1-03-01: Evidence for the Warburg effect in mammary atypia from high-risk African American women.
Authors: V Seewaldt, A Hoffman, C Ibarra-Drendall
Journal: Cancer Research (2012)

Abstract Background: Aggressive cancers are known to consume glucose avidly and produce lactic acid (rather than fully metabolize glucose via the Tricarboxylic Acid (TCA) cycle). This shift toward lactate production, even in the presence of adequate oxygen, is termed the Warburg effect. The Warburg effect is thought to be a late event in breast cancer, however, our studies in high-risk women provide evidence that the Warburg effect occurs during cancer initiation. This is an important observation as glucose-signaling can be readily targeted for breast cancer prevention with minimal toxicity. Here we investigated the role of the Warburg effect in breast cancer initiation in young high-risk women. Methods and Results: Similar to fluorodeoxyglucose, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) is a fluorescent glucose analog that can be used to track glucose uptake and glycolysis. 2-NBDG spectroscopy provides a means to track glucose metabolism in live mammary epithelial cells from high-risk women. We used 2-NBDG spectroscopy to measure glucose uptake in ER− breast cancer and live atypical mammary epithelial cells from high-risk premenopausal women. We observe that both triple-negative breast cancer and a subset of atypia exhibits accumulation of 2-NBDG. There is growing recognition that phosphoprotein signaling networks (rather than single genes) play a key role in breast cancer initiation and progression. Our team used Reverse Phase Proteomic Microarray (RPPM) profiling to test for activation of phosphoprotein signaling networks in atypical RPFNA cytology from high-risk premenopausal women in our cohort. RPFNA were obtained from two independent sets of 39 and 38 high-risk premenopausal women; 45% of these women were African American. The signaling network most highly expressed in precancerous cells contained activated signaling proteins associated with the Warburg effect (AKT/mTOR/PI3K), insulin signaling (pACC, IRS1) and epithelial to mesenchymal transition (EMT) IL6/Stat3/vimentin. Conclusions: This is the first evidence that abnormal glucose uptake and the Warburg effect occurs during breast cancer initiation in high-risk premenopausal women. These studies demonstrate our ability to identify abnormal glucose and activated signaling networks associated with the Warbug effect in atypical mammary cells from high-risk women. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-03-01.
Cervical Cytology and Reimbursement Issues
Authors: T. S. Neely
Journal: JAMA (1990)

To the Editor.—  Dr Ohrt, 1 editorializing on the Bethesda classification of cervical/vaginal cytology, writes as follows: Using a conservative, established protocol for the first follow-up of a mildly abnormal Papanicolaou test result, we can estimate that the conservative physician's treatment of a low-grade squamous epithelial lesion will result in an added cost in the range of $50 to $70. He references this statement with a technical bulletin from the American College of Obstetrics and Gynecology. In review of this technical bulletin, there is no treat and repeat approach for mildly abnormal Papanicolaou smears. The bulletin, in fact, states that although a repeat Pap smear may be of benefit in confirming the diagnosis of pre-invasive cervical neoplasia... [a] single negative report on a repeat smear does not eliminate the need for a thorough diagnostic evaluation. 2   Dr Ohrt also characterizes low-grade squamous intraepithelial lesions as relatively innocuous. It is true
Spontaneous megakaryocytic colony formation does not discriminate between essential thrombocythemia and polycythemia vera
Authors: Martine Escoffre-Barbe, Laurence Amiot, Pascale Beaucournu, Patrick Jego, Isabelle Grulois, Bernard Grosbois, Marc Bernard, Thierry Fest, Thierry Lamy, Olivier Fardel
Journal: American Journal of Hematology (2006)

Laboratory detection of spontaneous growth of colony-forming unit-megacaryocytes (CFU-MK), allowing us to distinguish essential thrombocythemia (ET) from reactive thrombocytosis, is therefore useful for the diagnostic of this myeloproliferative disorder. Whether CFU-MK assays allow us to discriminate at least partly between ET and other myeloproliferative disorders such as polycythemia vera (PV) remains, however, to be established. To gain insights about this point, we have performed CFU-MK cultures from bone marrow cells of patients diagnosed with ET (n = 42) or PV (n = 50) using a standardized collagen-based serum-free method. Spontaneous growth of CFU-MK was similarly detected in both 40/42 patients with ET and 47/50 patients with PV. These data suggest clearly that the CFU-MK assay is useful to detect not only ET, but also PV, but fails to discriminate, even partly, between these two myeloproliferative disorders. Am. J. Hematol. 81:554–556, 2006. © 2006 Wiley-Liss, Inc.
Improvement of Atrial Function and Atrial Reverse Remodeling After Cardiac Resynchronization Therapy for Heart Failure
Authors: Cheuk-Man Yu, Fang Fang, Qing Zhang, Gabriel W.K. Yip, Chun Mei Li, Joseph Yat-Sun Chan, LiWen Wu, Jeffrey Wing-Hong Fung
Journal: Journal of the American College of Cardiology (2007)
Transgastric endoscopic ultrasound (EUS)-guided gallbladder drainage for acute cholecystitis
Authors: K. Kamata, M. Kitano, T. Komaki, H. Sakamoto, M. Kudo
Journal: Endoscopy (2009)

Acute cholecystitis occurs in 4 % – 7 % of patients with a covered metallic stent (CMS) placed in the bile duct [1] [2]. Percutaneous transhepatic gallbladder drainage, which involves an external drainage tube, decreases the ability of the patient to carry out their normal daily activities. Recently, endoscopic ultrasound (EUS)-guided drainage has been employed successfully for hepatogastrostomy, bilioduodenostomy, and pancreatogastrostomy [3] [4] [5]. We report here a patient who underwent EUS-guided gallbladder drainage for acute cholecystitis caused by CMS placement.
Association of Phosphorylated Serine/Arginine (SR) Splicing Factors With The U1–Small Ribonucleoprotein (snRNP) Autoantigen Complex Accompanies Apoptotic Cell Death
Authors: Paul J. Utz, Maria Hottelet, Walther J. van Venrooij, Paul Anderson
Journal: The Journal of Experimental Medicine (1998)

Proteins subject to proteolysis or phosphorylation during apoptosis are commonly precipitated by autoantibodies found in the serum of patients with systemic lupus erythematosus (SLE). We screened a panel of murine monoclonal and human monospecific sera reactive with known autoantigens for their ability to selectively precipitate phosphoproteins from apoptotic Jurkat T cell lysates. Sera known to recognize the U1–small nuclear ribonucleoprotein (snRNP) complex (confirmed by their ability to precipitate U1–snRNA) selectively precipitated a phosphoprotein complex (pp54, pp42, pp34, and pp23) from apoptotic lysates. Monoclonal antibodies reactive with U1–snRNP proteins precipitated the same phosphoprotein complex from apoptotic lysates. The phosphorylation and/or recruitment of these proteins to the U1–snRNP complex is induced by multiple apoptotic stimuli (e.g., Fas ligation, gamma irradiation, or UV irradiation), and is blocked by overexpression of bcl-2. The U1–snRNP-associated phosphoprotein complex is immunoprecipitated by monoclonal antibodies reactive with serine/arginine (SR) proteins that comprise a structurally related family of splicing factors. The association of phosphorylated SR proteins with the U1–snRNP complex in cells undergoing apoptosis suggests a mechanism for regulation of alternative splicing of apoptotic effector molecules.