tbuckley/cabot-search huggingface dataset:
Can general practitioners compete with big business?: NHS privatisation was piloted in prisons
Authors: Andrew J Ashworth
Journal: BMJ (2006)

EDITOR—It is no surprise to see NHS general practice being eroded by big business.1 Doctors advocate for all their patients; politicians (the “owners” of the NHS) have pressures that are often at odds with those of patients and therefore their doctors.

By seeking a system that reduces doctors' responsibility for patients to an employment contract (with minimum and maximum standards set by managers), …
Recruitment Maneuvers during Lung Protective Ventilation in Acute Respiratory Distress Syndrome
Authors: ANA VILLAGRÁ, ANA OCHAGAVÍA, SARA VATUA, GASTÓN MURIAS, MARIA DEL MAR FERNÁNDEZ, JOSEFINA LOPEZ AGUILAR, RAFAEL FERNÁNDEZ, LLUIS BLANCH
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

The objective was to analyze the physiologic effects of recruitment maneuvers (RM) in 17 patients with acute respiratory distress syndrome (ARDS) ventilated with a lung protective strategy. RM consisted of 2 min of pressure-controlled ventilation at a peak pressure of 50 cm H2O and a positive end-expiratory pressure (PEEP) above the upper inflection point of the respiratory pressure–volume curve obtained at zero PEEP. In eight patients, RM were repeated in the late phase of ARDS. Oxygenation did not change 15 min after RM in the early and late phase of ARDS. When PaO2 /fraction of inspired oxygen (Fi O2 ) increased during RM, venous admixture (Q˙ va/Q˙ t) decreased. The opposite occurred in patients in whom PaO2 /Fi O2 decreased during RM. RM-induced changes in cardiac output were not observed. A significant correlation was found between RM-induced changes in PaO2 /Fi O2 during the RM and changes in respiratory system compliance at 15 min (r = 0.66, p < 0.01) and RM-induced changes in Q˙ va/Q˙ t (r = − 0.85; p < 0.01). The correlation between RM-induced changes in PaO2 /Fi O2 in responders (improvement in PaO2 /Fi O2 of greater than 20% during the RM) and the inspired oxygen fraction was also significant. In ARDS patients ventilated with a lung protective strategy we conclude that RM have no short-term benefit on oxygenation, and regional alveolar overdistension capable of redistributing blood flow can occur during RM.
Serologic Detection of Gonorrhea
Authors: John D. Schmale
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 August 1970Serologic Detection of GonorrheaEVELYN V. HESS, M.D., F.A.C.P., MARY JANE HEIMBROCK, B.S.EVELYN V. HESS, M.D., F.A.C.P.Search for more papers by this author, MARY JANE HEIMBROCK, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-2-340 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We were very pleased to see in the April 1970 issue of the ANNALSrecognition of the fact that gonorrhea and its complications still constitute a medical problem in this country. The review on gonorrhea by Drs. Schroeter and Pazin (Ann Intern Med72:553-559, 1970) is an excellent one. We would like to reinforce the statement that the antibiotic treatment of gonococcal arthritis should be continued for 10 to 14 days and that penicillin in the range of 5 to 10 million units be given. Our experience with the treatment of gonococcal arthritis during the past year... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EVELYN V. HESS, M.D., F.A.C.P.; MARY JANE HEIMBROCK, B.S.Affiliations: Division of Immunology University of Cincinnati Medical Center Cincinnati, Ohio 45229 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1970Volume 73, Issue 2Page: 340-341KeywordsArthritisGonorrheaPenicillin ePublished: 1 December 2008 Issue Published: 1 August 1970 PDF downloadLoading ...
Seasonality in Sudden Infant Death Syndrome
Authors: Millard Bass
Journal: JAMA (1991)

To the Editor.  ——A major objective of the Centers for Disease Control (CDC) Mortality and Morbidity Weekly Report is to document disease trends accurately. The effort to achieve this goal in the CDC study on sudden infant death and seasonality 1 was weakened by a failure to exclude cases certified as sudden infant death syndrome (SIDS) in which a death-scene investigation was not performed. Contrary to common belief, a high autopsy rate in a SIDS study confirmed by death certificate data does not strengthen the validity of this study when information is lacking concerning death-scene investigation of the presumed SIDS cases. 2,3   The observation by the author of the CDC report that the risk of SIDS was greatest for those white male infants whose mothers resided in the western United States must be cautiously interpreted since nonwhite Hispanic infants may be classified as white on death certificates. Because the incidence
GW25-e4279 Effect of Intracoronary Anisodamine and Diltiazem Administration during Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction
Authors: Peng Yuhong, Wei L, Wei Geng, Kun Xing, Leisheng Ru, Jiaan Sun, Yuying Zhao, Xianghua Fu
Journal: Journal of the American College of Cardiology (2014)
Factors influencing tuberculosis screening in healthcare workers in Portugal
Authors: José Moura Meireles, Rita Gaio, Raquel Duarte
Journal: European Respiratory Journal (2014)

Although the incidence of tuberculosis (TB) has increased in healthcare workers (HCWs) [1–3], several studies have shown that HCWs are not compliant with screening and/or preventive measures [4–7]. For example, a Portuguese study found that the estimated TB incidence was three- to seven-fold higher in HCWs than in the general population [8]. Latent TB infection (LTBI) diagnosis and treatment constitute the core of TB elimination, integrating the post-2015 strategies of the World Health Organization [9, 10]. Institutions should have more effective TB screening and HCWs should receive training to make informed decisions <http://ow.ly/BSitS> The authors would like to thank all healthcare workers who voluntarily responded to the survey.
Hypervitaminosis A
Authors: John F. Naz, Walton M. Edwards
Journal: New England Journal of Medicine (1952)

THE clinical entity hypervitaminosis A has become more clearly understood since Josephs1 first noted the toxic effects of excessive ingestion of the vitamin. The investigations of Toomey and Morissette,2 Dickey and Bradley,3 Rothman and Leon,4 Caffey,5 Fried and Grand,6 Gribetz, Silverman and Sobel7 and Wyatt, Carabello and Fletcher8 have helped greatly in the evaluation of vitamin A toxicity in children.These investigators are in close agreement on clinical findings. Three factors are necessary for the diagnosis of hypervitaminosis A. They are: a history of excessive ingestion of the vitamin; increased vitamin A levels in the blood; and cortical hyperostoses. Other . . .
640 A RANDOMIZED, DOUBLE-BLIND, CONTROLLED TRIAL COMPARING COAXIAL TECHNIQUE AND CONVENTIONAL REPEATED PUNCTURES FOR LIVER BIOPSY
Authors: S.Y. Park, W.Y. Tak, Y.O. Kweon, K.Y. Shin, S.Y. Ahn, J. Heo, W.K. Yoon
Journal: Journal of Hepatology (2012)
Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ
Authors: Elzbieta Janda, Camillo Palmieri, Antonio Pisano, Marilena Pontoriero, Enrico Iaccino, Cristina Falcone, Giuseppe Fiume, Marco Gaspari, Maria Nevolo, Emanuela Di Salle, Annalisa Rossi, Annamaria De Laurentiis, Adelaide Greco, Daniele Di Napoli, Elwin Verheij, Domenico Britti, Luca Lavecchia, Ileana Quinto, Giuseppe Scala
Journal: Blood (2011)
Physiological and toxicological aspects of smoke produced during the combustion of polymeric materials.
Authors: I N Einhorn
Journal: Environmental Health Perspectives (1975)

Normally one expects that flame contact is the major cause of injury and death during fires. Analysis of the factors involved in numerous fires has revealed that most deaths were not due to flame contact, but were a consequence of the production of carbon monoxide, nitrogen oxides, and other combustion products, such as aldehydes, low molecular weight alcohols, hydrogen cyanide, and other noxious species. The major emphasis within the scope of this paper relates to the physiological and toxicological aspects of smoke produced during the combustion of materials. Special emphasis is directed toward laboratory procedures which have been developed to determine the qualitative and quantitative analysis of smoke, factors pertaining to smoke development, and to measure the response of laboratory animals exposed to smoke. The effects that fire retardants, incorporated into polymeric materials as a means of improving flammability characteristics, may have on smoke development, the mechanism of polymer degradation, and on the survival response of laboratory animals are also considered.
Streptococcal Sore Throat
Authors: P. W. Ross
Journal: BMJ (1972)

motor end plates of the lower portion of the face where the injury was situated the concentration of the toxin could have been high enough to produce palsy.The other possibility would be for the toxin to ascend up the nerve fibres in high enough concen- tration to paralyse the motor end plates while some toxin could be absorbed via the blood stream to reach the C.N.S., and give rise to genealized excitatory features.Whatever the explanation, facial palsy as a complication of tetanus is a rare occurrence.An intriguing aspect of the case was that the forehead had escaped while the lower portion of the face (including the orbicularis oculi) was affected.-Weare, etc.,
Modulation of Basal and Receptor-Induced GIRK Potassium Channel Activity and Neuronal Excitability by the Mammalian PINS Homolog LGN
Authors: Ofer Wiser, Xiang Qian, Melissa Ehlers, William W. Ja, Richard W. Roberts, Eitan Reuveny, Yuh Nung Jan, Lily Yeh Jan
Journal: Neuron (2006)
Molecular Predictors of Cognitive Involvement in Female Carriers of Fragile X Syndrome
Authors: Annette K. Taylor, John F. Safanda, Majilinde Z. Fall, Cindy Quince, Kirsten A. Lang, Claire E. Hull, Isabelle Carpenter, Louise W. Staley, Randi J. Hagerman
Journal: JAMA (1994)

<h3>Objective.</h3> —Fragile X syndrome is caused by a mutation involving expansion of a CGG trinucleotide repeat segment in the fragile X mental retardation—1 (<i>FMR1</i>) gene on the long arm of the X chromosome. This study was undertaken to determine the relative impact of three molecular characteristics of the<i>FMR1</i>mutation— number of CGG repeats, methylation status, and X inactivation ratio—on the cognitive involvement of female carriers of fragile X syndrome. <h3>Design.</h3> —Retrospective study with new DNA analysis of known female carriers of fragile X syndrome. <h3>Setting.</h3> —Molecular studies were conducted in a university-based DNA diagnostic laboratory. Patients were originally ascertained through a regional fragile X clinic in a university-affiliated pediatric hospital. <h3>Patients.</h3> —Forty-eight female carriers of fragile X syndrome were studied, including 22 with a premutation (a small expansion to approximately 50 to 200 CGG repeats), 23 with a full mutation (a full expansion to &gt;200 CGG repeats), and three with both types of mutations (mosaics). <h3>Results.</h3> —Median IQ score was significantly lower for females with a full mutation than for females with a premutation. No significant relationship was found between IQ score and number of CGG repeats or percentage methylation of the mutant allele within each mutation category. In addition, no significant relationship was found between IQ score and the proportion of normal<i>FMR1</i>alleles on the active X chromosome in the carrier female group as a whole or in either mutation subgroup. Comparisons of leukocytes and saliva-borne epithelial cells in certain full-mutation carriers revealed striking differences in<i>FMR1</i>mutation sizes. <h3>Conclusions.</h3> —Mutation category remains the most important predictor of affectedness in female carriers of fragile X syndrome. Our data do not support use of the proportion of normal<i>FMR1</i>alleles on the active X chromosome as a predictor of cognitive involvement in female carriers with full mutations. Individual tissue-specific differences exist in the heterogeneous sizes of full mutations and in the presence of premutation/full-mutation mosaicism. (<i>JAMA</i>. 1994;271:507-514)
Paraneoplastic pemphigus in association with Castleman's disease
Authors: O.V. Nikolskaia, C.H. Nousari, G.J. Anhalt
Journal: British Journal of Dermatology (2003)

Journal Article Paraneoplastic pemphigus in association with Castleman's disease Get access O.V. Nikolskaia, O.V. Nikolskaia Department of Dermatology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building, Suite 771, Baltimore, MD 21205, U.S.A. *Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar C.H. Nousari, C.H. Nousari Department of Dermatology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building, Suite 771, Baltimore, MD 21205, U.S.A. *Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar G.J. Anhalt G.J. Anhalt Department of Dermatology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building, Suite 771, Baltimore, MD 21205, U.S.A. *Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A Grant J.Anhalt. E‐mail: Ganhalt@JHMI.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 6, 1 December 2003, Pages 1143–1151, https://doi.org/10.1111/j.1365-2133.2003.05659.x Published: 01 December 2003 Article history Accepted: 22 May 2003 Published: 01 December 2003
Discrepancy between plasma and aortic wall cyclic guanosine monophosphate in an experimental model of congestive heart failure
Authors: J.-F. Arnal, F. Hofmann, J.-B. Michel
Journal: Cardiovascular Research (1993)

Journal Article Discrepancy between plasma and aortic wall cyclic guanosine monophosphate in an experimental model of congestive heart failure Get access Jean-François Arnal, Jean-François Arnal Unit 367 INSERM, 17 rue du Fer-à-Moulin, 75005 Paris, France: J-F Arnal, J-B Michel; Institut für Pharmacologie und Toxikologie, TU München, Biedersteiner Strasse 29, 8000 München 40, Germany: F Hofmann. Correspondence to Dr Arnal. Search for other works by this author on: Oxford Academic PubMed Google Scholar Franz Hofmann, Franz Hofmann Unit 367 INSERM, 17 rue du Fer-à-Moulin, 75005 Paris, France: J-F Arnal, J-B Michel; Institut für Pharmacologie und Toxikologie, TU München, Biedersteiner Strasse 29, 8000 München 40, Germany: F Hofmann. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Baptiste Michel Jean-Baptiste Michel Unit 367 INSERM, 17 rue du Fer-à-Moulin, 75005 Paris, France: J-F Arnal, J-B Michel; Institut für Pharmacologie und Toxikologie, TU München, Biedersteiner Strasse 29, 8000 München 40, Germany: F Hofmann. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 6, June 1993, Pages 1094–1100, https://doi.org/10.1093/cvr/27.6.1094 Published: 01 June 1993 Article history Received: 08 October 1992 Accepted: 04 January 1993 Published: 01 June 1993
From “Pull” to “Push”: A Transformation in Medicine
Authors: Aaron Barak Neinstein
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Pericardial and Myocardial Disease Associated with Serological Evidence of Infection by Agents of the Psittacosis-Lymphogranuloma Venereum Group (Chlamydiaceae)
Authors: GEORGE C. SUTTON, RICHARD A. MORRISSEY, JOHN R. TOBIN, TRUMAN O. ANDERSON
Journal: Circulation (1967)

Nine patients with acute pericarditis or myocarditis, or both, were found to have serological evidence of concurrent infection by a psittacosis agent. Three patients had conclusive epidemiological and clinical evidence of complicating pulmonary psittacosis and demonstrated that psittacosis agent does produce inflammatory heart disease in this geographic area. Six patients had imperfect corroborative evidence of psittacosis and their clinical manifestations were atypical. Indeed, half of these patients were initially believed to have some form of idiopathic myocardial disease. Studies of these patients suggest that psittacotic infection m ay be causal in certain forms of heart disease commonly designated primary myocardial disease.
Synthesis of C1 inhibitor in fibroblasts from patients with type I and type II hereditary angioneurotic edema.
Authors: J Kramer, Y Katz, F S Rosen, A E Davis, R C Strunk
Journal: Journal of Clinical Investigation (1991)

Patients with hereditary angioneurotic edema (HANE) have serum levels of functionally active inhibitor of the first component of complement (C1 INH) between 5 and 30% of normal, instead of the 50% expected from the single normal allele. Increases in rates of catabolism have been documented in patients with HANE and certainly account for some of decrease in C1 INH level. A possible role for a decrease in synthesis of C1 INH in producing serum levels of C1 INH below the expected 50% of normal has not been well studied. We studied the synthesis of C1 INH in skin fibroblast lines, which produce easily detectable amounts of C1 INH. In type I HANE cells, C1 INH synthesis was 19.6 +/- 4.0% (mean +/- SD) of normal, much less than the 50% predicted. In type II HANE cells, the total amount of C1 INH synthesis (functional and dysfunctional) was 98.9 +/- 17% of normal; the functional protein comprised 43% of the total. Thus, type II HANE cells synthesized functional C1 INH at a much greater rate than for the type I cells. In both type I and II HANE cells, amounts of steady-state C1 INH mRNA levels paralleled rates of C1 INH synthesis, indicating that control of C1 INH synthesis occurred at pretranslational levels. Both type I and type II fibroblasts synthesized normal amounts of C1r and C1s. These data suggest that the lower than expected amounts of functionally active C1 INH in type I HANE may be due, in part, to a decrease in rate of synthesis of the protein, and that the expressions of the normal C1 INH allele in HANE is influenced by the type of abnormal allele present.
Elevated Diaphragm From Hematoma
Authors: Bernard Jay
Journal: JAMA (1971)

To the Editor.—  We wish to add another entity to the differential diagnosis of an elevated hemidiaphragm.  Report of a Case.—  A 37-year-old white man was admitted to Georgetown University Hospital for evaluation of hepatomegaly. There was a 15-year history of heavy alcohol intake. On admission, the hematocrit value was 46.5%, and the x-ray film of the chest was normal (Fig 1). A liver biopsy performed on the second hospital day was consistent with Laennec's cirrhosis. Later that day, the patient complained of right-sided pleuritic pain in the chest. The hematocrit value had fallen to 37.5% while the x-ray film of the chest showed elevation of the right hemidiaphragm with basilar discoid atalectasis (Fig 2). The fall in hematocrit value was attributed to hemorrhage from the liver biopsy. Although no further diagnostic studies were done, it was assumed that the elevation of the right diaphragm was secondary to hematoma formation
Effect of heliotherapy on the cost of psoriasis
Authors: None Snellman, None Maljanen, None Aromaa, None Reunanen, None Jyrkinen‐Pakkasvirta, None Luoma
Journal: British Journal of Dermatology (1998)

A 2-year trial was conducted to evaluate the cost-effectiveness of heliotherapy for psoriasis. The course and cost of psoriasis of 46 Finnish patients were first closely monitored for 1 year, then the patients received a 4-week supervised heliotherapy treatment in the Canary Islands, Spain, after which they continued to be followed for another year. Heliotherapy dramatically reduced the severity of psoriasis and also seemed to have favourable long-term effects on psoriasis. The mean direct cost of the 4-week heliotherapy for one patient was FIM12,289 (£1 = FIM7.0 in 1989). The cost of flights and half-board in Spain formed nearly 60% (FIM7033) of the total cost. In the year preceding heliotherapy, the mean direct annual cost of antipsoriasis therapy was FIM7335 and in the year after FIM5700, a reduction of 22% in annual costs; this change was not statistically significant because there were large variations in costs among patients. The costs of heliotherapy exceeded manyfold the mean monthly cost of conventional psoriasis therapy. There were no overall savings using heliotherapy in those patients suffering mainly from moderately severe psoriasis. Heliotherapy saved costs only in those patients with severe psoriasis that required expensive medication or ward treatment. Although heliotherapy cannot be regarded as an economical treatment for the average patients with psoriasis, it clears psoriasis effectively and is preferred by patients. Thus, heliotherapy constitutes an alternative for patients suffering severe psoriasis.