tbuckley/cabot-search huggingface dataset:
High Incidence of Gastrointestinal Tract Disorders and Autoimmunity in Primary Cutaneous Marginal Zone B-Cell Lymphomas
Authors: Joan Guitart, Janyana Deonizio, Tara Bloom, Maria Estela Martinez-Escala, Timothy M. Kuzel, Pedram Gerami, Mary Kwasny, Steve T. Rosen
Journal: JAMA Dermatology (2014)

<h3>Importance</h3> To our knowledge, this is the first comprehensive study addressing comorbidities associated with primary cutaneous marginal zone B-cell lymphomas (PCMZLs). <h3>Objective</h3> To determine if patients with PCMZL were at risk for other medical conditions. <h3>Design, Setting, and Participants</h3> Case-control study at a cutaneous lymphoma clinic and a dermatopathologic consultation service at a single academic institution using an extensive questionnaire of illnesses, symptoms, and environmental exposures for 80 sequential patients with PCMZL and 80 matched controls. <h3>Main Outcomes and Measures</h3> The frequency of several morbidities was obtained in both groups from data gathered from the questionnaire and corroborated by reviewing medical records when available. <h3>Results</h3> We found a high incidence of past or present gastrointestinal tract problems in 49 patients (61.2%) with PCMZL compared with 30 participants (37.5%) in the control group (CG) (<i>P</i> = .003). Gastroesophageal reflux was reported in 50.0% (40 vs 27 in the CG,<i>P</i> = .04) and gastric ulcers in 10.0% (8 vs 3 in the CG,<i>P</i> = .13); 20.0% of the cohort had positive<i>Helicobacter pylori</i>serology (16 vs 2 in the CG,<i>P</i> = .003). Colon disorders, including irritable bowel syndrome and inflammatory bowel disease, were more common in the PCMZL cohort (20 vs 7 in the CG,<i>P</i> = .01). Autoimmunity was reported in 20.0% of participants (16 vs 6 in the CG,<i>P</i> = .03). Eight patients had a history of Hashimoto thyroiditis. Three patients had a positive antinuclear antibody. Two had a diagnosis of lupus erythematosus and 1 had Sjögren syndrome. Sicca syndrome was noted in 12.5% (10 vs 3 in the CG,<i>P</i> = .052). A history of noncutaneous malignant neoplasms was observed in 21.3% of the patients (17 vs 8 in the CG,<i>P</i> = .050). Other notable morbidities did not reach statistical significance. <h3>Conclusions and Relevance</h3> Our results indicate a high incidence of systemic conditions in patients with PCMZL, especially involving the gastrointestinal tract, but also autoimmunity and cancer.
Collagen Scaffold Arrays for Combinatorial Screening of Biophysical and Biochemical Regulators of Cell Behavior
Authors: Steven R. Caliari, Emily A. Gonnerman, William K. Grier, Daniel W. Weisgerber, Jessica M. Banks, Aurora J. Alsop, Jae‐Sung Lee, Ryan C. Bailey, Brendan A. C. Harley
Journal: Advanced Healthcare Materials (2014)

Arrays of 3D macroporous collagen scaffolds with orthogonal gradations of structural and biomolecular cues are described. Gradient maker technology is applied to create linear biomolecular gradients within microstructurally distinct sections of a single CG scaffold array. The array set up is used to explore cell behaviors including proliferation and regulation of stem cell fate.
TCT-499 Prediction of lesion type related MACE by sFLT-1 and GDF-15. Results from The PROSPECT study
Authors: Martin Mockel, Bernard De Bruyne, Patrick Serruys, Giora Weisz, Fabian Holert, Christian Müller, Reinhold Muller, Anna Slagman, Ke Xu, Julia Searle, Gregg Stone
Journal: Journal of the American College of Cardiology (2012)
Treadmill performance and selected physiological characteristics of wheelchair athletes.
Authors: H K Lakomy, I Campbell, C Williams
Journal: British Journal of Sports Medicine (1987)

The purpose of this study was to examine selected physiological characteristics and pushing performance over a distance of five kilometres (5 km) in twelve wheelchair athletes (10 paraplegics and 2 tetraplegics). The physiological tests and 5 km wheelchair time trials were performed on a motorised treadmill adapted for use by wheelchairs. The maximum oxygen uptake (VO2 max) and %VO2 max utilised at a fixed speed equivalent to a blood lactate concentration of 4 mmol.l-1, identified as being of importance in successful able-bodied endurance performance, were also found to correlate highly with 5 km performance in wheelchair athletes. Low correlations were found between performance and mean %VO2 max utilised over the whole distance and between performance and oxygen uptake at a standard speed. The results also showed that the tetraplegics had lower physiological reserves than the paraplegics, with a much reduced maximum heart rate and ventilation. The findings indicate that a combination of physiological characteristics influence pushing performance in wheelchair athletes.
An expert witness falls from grace
Authors: N. Marks
Journal: BMJ (2003)

Sir Roy Meadow in the media firing line 

Since the Court of Appeal cleared Sally Clark in January of murdering her two babies and, more recently, a jury took just 90 minutes to acquit Trupti Patel of triple murder, Sir Roy Meadow, professor of paediatrics and expert witness, has faced a growing critical onslaught from press and broadcast journalists.

But it was not so long ago that the media was ringing enthusiastically to Sir Roy's soundbites. These included the one in 73 million statistic he cited in the Clark trial as the chance of a cot death occurring twice in the same family, or the so called Meadow's law–that one cot death is a tragedy, two suspicious, three murder–put forward in the Patel case.

So what is going on? Have the media reappraised the eminent professor's work, considered new evidence in the field of genetics, studied the defects …
Isoniazid and Levodopa
Authors: JOHN P. MORGAN
Journal: Annals of Internal Medicine (1980)

Letters1 March 1980Isoniazid and LevodopaJOHN P. MORGAN, M.D.JOHN P. MORGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-434_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The letter of Lejonc and colleagues (1) in the November 1979 issue on a patient who developed flushing and palpitations and, later, elevated pulse rate and blood pressure as an apparent interaction between cheese and isoniazid awakened a memory.In 1970, a patient whom I had treated with levodopa for Parkinson's disease complained of agitation, flushing, palpitations, and severe tremor. His blood pressure was indeed elevated, although not to dangerous levels. His tremor, not previously present, was not Parkinsonian. The apparently important change in his medication had come from a recent decision to begin isoniazid therapy (I...Reference1. LEJONCGUSMINIBROCHARD JPP. Isoniazid and reaction to cheese. Ann Intern Med. 1979;91:793. Letter. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug Interactions with Agents Used in the Treatment of CNS DisordersParkinsonism—Drug Treatment: Part IIsoniazid, Meperidine, and HypotensionRICHARD GANNON, PHARM. D., WENDY PEARSALL, R.N., RICHARD ROWLEY, M.D.Monoamine oxidase inhibitors and their pharmacological significanceMonoamine oxidase inhibitor efficacy in depression and the ‘cheese effect’Drugs used in tuberculosis and leprosy 1 March 1980Volume 92, Issue 3Page: 434-434KeywordsBlood pressureCheesesHeart rateIsoniazidLevodopaMemoryParkinson disease Issue Published: 1 March 1980 PDF DownloadLoading ...
Signs and symptoms in chronic heart failure: Relevance of clinical trial results to point of care-data from Val-HeFT
Authors: Maylene Wong, Lidia Staszewsky, Elisa Carretta, Simona Barlera, Roberto Latini, Yann-Tong Chiang, Robert D. Glazer, Jay N. Cohn
Journal: European Journal of Heart Failure (2005)
A6.6 Functional pathways in endothelial cells are differentially regulated by fibroblasts from patients with RA and resolving disease
Authors: HM McGettrick, N Naame, S He, K Raza, GB Nash, CD Buckley, A Filer
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> Fibroblasts have been shown to actively regulate the inflammatory infiltrate that accumulates within synovial joints. On way they achieve their effects in part by conversing with neighbouring vascular endothelial cells imparting a stromal "address code" that regulates leukocyte recruitment. Here we compared the ability of synovial fibroblasts from resolving arthritis and very early RA to communicate with vascular endothelial cells (EC). <h3>Methods</h3> Fibroblasts were isolated from synovial biopsies taken from treatment naive patients with a new onset of clinically apparent arthritis and symptom duration of ≤12weeks, who at follow-up had either a resolving arthritis or RA (VeRA). Endothelial cell-fibroblast co-cultures were formed using porous filters for 24 h prior to a further 24 h stimulation with tumour necrosis factor alpha and interferon gamma. Microarray analysis was performed on mRNA extracted from endothelial cells and evaluated using Ingenuity Pathway Analysis. <h3>Results</h3> Resolving and VeRA fibroblasts differentially modified the transcriptional profile of EC. There were 52 differentially expressed genes (76 probe sets) between the two conditions, with 21 genes expressed higher in EC from VeRA co-cultures compared to resolving co-cultures. These related to 18 ingenuity canonical pathways associated with cell signalling (e.g. Wnt and NKFB pathways), cellular differentiation, and metabolism (e.g. lipid and amino acid). <h3>Conclusions</h3> Fibroblasts from acutely resolving and early persistent arthritis are distinct. Differences in the way in which fibroblasts communicate with endothelial cells could be involved in the pathogenesis and perpetuation of the inflammatory response in the earliest clinically apparent phases of RA.
Anaphylaxis: opportunities of stratified medicine for diagnosis and risk assessment
Authors: F. Wölbing, T. Biedermann
Journal: Allergy (2013)

The risk to develop anaphylaxis depends on the sensitization pattern, the proportion of the involved immunoglobulin classes, the avidity and affinity of immunoglobulins to bind an allergen, characteristics of the allergen, the route of allergen application, and, last but not least, the presence of cofactors of anaphylaxis. To be able to calculate the risk to develop anaphylaxis and to anticipate the severity of the reactions under certain conditions, it is necessary to understand how all these factors interact with each other. Important progress for risk assessment in anaphylaxis is based on component-resolved stratified diagnostics, which allow to (i) determine a patient's sensitization pattern on a molecular basis, (ii) correlate clinical responses to defined sensitization patterns, and (iii) better identify cross-reactive allergens. Together with the increasing knowledge regarding the role and mode of action of cofactors of anaphylaxis, these data pave the way to unscramble the complex interactions determining the clinical relevance of sensitizations, the risk of anaphylaxis, and the severity of reactions. As a consequence, this understanding allows to better determine the individual risk in response to an identified allergen and results in more specific advices and education for our patients to prevent further life-threatening anaphylactic reactions.
Complete Regression of Human Neuroblastoma Xenografts in Athymic Mice After Local Newcastle Disease Virus Therapy
Authors: R. M. Lorence, K. W. Reichard, B. B. Katubig, H. M. Reyes, A. Phuangsab, B. R. Mitchell, C. J. Cascino, R. J. Walter, M. E. Peeples
Journal: JNCI Journal of the National Cancer Institute (1994)

Background : Neuroblastoma is the most common pediatric extra-cranial solid cancer. Using conventional ther apies, Children older than 1 year of age with advanced neuroblastoma have a poor progrnosis. The development of new approaches for treating such children with neuroblastoma continues to be one of the most important goals today in pediatric oncology. Despite numerous anecdotal reports of human tumor regression during viral infections, the use of viruses to directly lyse neuroblastoma cells has never been reported as a potential therapy.New-castle disease virus(NDV) has been shown to replicate in and kill cultured human and rat neuroblastoma cells but not normal human fibroblasts. Purpose : Our purpose was to determine if this selective killing of human neuroblastoma (IMR-32) cells is maintained during the in vivo treatment of established tumors. Mothods : Two experiments were performed using NDV strain 73-T Athymic mice with subcutaneous IMR-32 human neuriblastoma xenografts (6–12 mm) were treated intralesionally with live NDV, UV-inacivated NDV, or phosphate-buffered saline (PBS). To study vrius replication in situ, mice were given intraumoral or intramuscular injections of NDV. These mice were then killed at various times, and the amount of infectious viurs present in tumor or muscle was determined. Results : after one injection of live NDV, 17 of 18 tumorsregressed completely, Whereas rapid tumor growth occured in all 18 mice treated with PBS and in all nine mice treated with UV-inactivated NDV (P<.0001). The one tumor that showed only a partial response to asingle injection regressed completely after a second NDV treatment, six months following virus-induced regression, only one tumor had recurred.Nosignificant acute or chronic side effects of live NDV were noted in athymic mice given doses up to 500 times that used in this study. Virus levels increased more than 80-fold between 5 and 24 hours in virus-injected tumors(P<.04), while no infectious virus was produced in NDV-injected muscle tissue. Conclusions: NDv 73-T appears to replcate selectively in human IMR-32 neuroblastoma xenografts, leading directly to a potent antitumor effect as demonstrated by long-lasting, complete tumor regression occuring after a single local injection of virus. Implication: These experiments may proveide an important step in the development af new therapeutic approaches to challenging cancers such as neuroblastoma. [J Natl Cancer Inst 86: 1228–1233, 1994]
Gentamicin Sulfate, New Antibiotic Against Gram-Negative Bacilli
Authors: Rodolfo L. Jao, George Gee Jackson
Journal: JAMA (1964)

A laboratory and clinical evaluation was made of gentamicin sulfate which is a new antibiotic produced by a species of the genus<i>Micromonospora</i>. It has a broad spectrum that includes both<i>Pseudomonas</i>and<i>Proteus</i>organisms; staphylococci also are susceptible in vitro. Intramuscular injection produced antibacterial concentrations in the serum and urine. The drug is excreted almost entirely in active form by the kidney by glomerular filtration with little or no reabsorption. Uncomplicated urinary tract infections were successfully treated; cases with complicating conditions often relapsed. Gram-negative bacteremia responded infrequently to the doses used, but treatment was sometimes life saving. Labyrinthine intoxication was the only serious side effect observed and was always associated with pre-existing renal failure or a large dose.
Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
Authors: Ryuji Uchida, Seiko Ishikawa, Hiroshi Tomoda
Journal: Acta Pharmaceutica Sinica B (2014)

2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells.
Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients.
Authors: F Ikehata, J Satoh, K Nata, A Tohgo, T Nakazawa, I Kato, S Kobayashi, T Akiyama, S Takasawa, T Toyota, H Okamoto
Journal: Journal of Clinical Investigation (1998)

Cyclic ADP-ribose (cADPR) has been shown to be a mediator for intracellular Ca2+ mobilization for insulin secretion by glucose in pancreatic beta cells, and CD38 shows both ADP-ribosyl cyclase to synthesize cADPR from NAD+ and cADPR hydrolase to hydrolyze cADPR to ADP-ribose. We show here that 13.8% of Japanese non-insulin-dependent diabetes (NIDDM) patients examined have autoantibodies against CD38 and that the sera containing anti-CD38 autoantibodies inhibit the ADP-ribosyl cyclase activity of CD38 (P </= 0.05). Insulin secretion from pancreatic islets by glucose is significantly inhibited by the addition of the NIDDM sera with anti-CD38 antibodies (P </= 0.04-0.0001), and the inhibition of insulin secretion is abolished by the addition of recombinant CD38 (P </= 0.02). The increase of cADPR levels in pancreatic islets by glucose was also inhibited by the addition of the sera (P </= 0.05). These results strongly suggest that the presence of anti-CD38 autoantibodies in NIDDM patients can be one of the major causes of impaired glucose-induced insulin secretion in NIDDM.
Statistical hypothesis testing
Authors: P. Sedgwick
Journal: BMJ (2010)

A randomised controlled trial evaluated the cost and efficacy of community leg ulcer clinics that used four layer compression bandaging. The control treatment was provision of usual care by district nurses.1 Over the 12 months of follow-up, ulcers healed more quickly in the clinic group than in the control group (P=0.03). Statistical tests were two sided. Which of the following, if any, are true?
Ileus related to wireless capsule retention in suspected Crohn’s disease: emergency surgery obviated by early pharmacological treatment
Authors: L. Vanfleteren, P. van der Schaar, J. Goedhard
Journal: Endoscopy (2009)

A previously healthy 21-year-old woman without a history suggesting stenosis and normal ileocolonoscopic findings underwent wireless capsule endoscopy (PillCam SB 11 × 26 mm; Given Imaging, Yoqneam, Israel) for suspected Crohn's disease of the small bowel. Approximately 16 hours after capsule intake, she developed small-bowel ileus ([Fig. 1]). The capsule recording showed skip lesions of inflamed small bowel with ulcerations, swelling, pseudopolyps, and stenosis ([Fig. 2]). After 6.5 hours, capsule progression was halted by a strictured small-bowel segment with severely active disease ([Fig. 3]). A diagnosis of severe stenosing Crohn's disease of the small bowel with subsequent capsule retention leading to obstruction of the small bowel was made.
Change of Heart: The Bypass Experience
Authors: Judith A. Sutin
Journal: JAMA (1986)

In these times of technological advance, the unimaginable seems to have become the routine. Yet any recipient of a medical opinion or procedure (regardless of its simplicity or complexity) recognizes some common and traditional expectations for their physician. Beyond the professional skills, judgment, and competence, does the physician discuss the situation, include the patient in the decisionmaking process, remain available, and express sympathetic concern? Is he or she gracious, sensitive, and reassuring or arrogant and distant? Does the physician impart a sense of personal interest and investment in the patient's recovery, suggesting a commitment to the improvement of the predicament?<i>Change of Heart: The Bypass Experience</i>serves to remind us of the emotional toll of these experiences, particularly when one is facing a critical and unanticipated juncture, one that necessitates a total surrender of control. This extremely readable book is drawn from the experiences of 800 questionnaire respondents and 200
Thrombocytopenia in Congenital Rubella
Authors: Joseph S. Reiss, Charles V. Pryles
Journal: New England Journal of Medicine (1966)

THE syndrome of congenital rubella has been expanded to include such manifestations as neonatal thrombocytopenia, hepatosplenomegaly and regurgitative jaundice, interstitial pneumonitis and bone lesions. The case presented below appears to be unique in comparison with others reported because of the late onset and recurrence of thrombocytopenia as well as the persistence of osseous changes and the coexistence of Hirschsprung's disease.Case ReportT.G., a Negro boy, was delivered at term without complications with a birth weight of 3175 gm. (7 pounds). His mother had had fever and a generalized rash during the 9th week of pregnancy. On the 3d day . . .
Cholera in Portugal
Authors: Eugene J. Gangarosa
Journal: JAMA (1975)

To the Editor.—  The INTERNATIONAL COMMENT on cholera in Portugal (234:329, 1975) incorrectly stated that a Center for Disease Control publication ( Morbidity and Mortality Weekly Report , Aug 15, 1975) warned visitors to Portugal to drink only bottled  In fact, the article recommended that travelers to Portugal and other cholera-infected areas drink only bottled carbonated beverages and boiled or chemically disinfected  The qualification about carbonation is important because many brands of noncarbonated bottled water receive no treatment. At least one outbreak of diarrheal illness has been traced to commercially bottled noncarbonated water. Carbonated water, however, has a low pH and is less likely to permit survival of pathogens.
David B. Simpson, MD
Authors: Ling-Ju Yen
Journal: JAMA (1994)

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