tbuckley/cabot-search huggingface dataset:
Recovery of a Broken Bougie from the Bladder
Authors: G. E. Walker
Journal: BMJ (1880)

discharge of some kind was to be provided for.But it is now long since I first brought this matter before the profession, and from the first I have stated that a serous oozing always occurs, profuse and tinged with blood in the first instance, and afterwards diminishing, but almost invariably continuing in small amount for a protracted period.Mr. Spence's charge would have had exactly the same basis as it has, if every case of psoas abscess were cured within a week under antiseptic treatment, pro- vided that during that week, or even during two hours, a serous dis- charge occurred.My statement had reference to the great new patho- logical truth of the cessation of suppuration from the pyogenic mem- brane and carious bone when a vertebral abscess is opened and treated antiseptically in combination with free drainage, while rest is given to the weak part of the spine by the recumbent posture.Under these circumstances, the chronically inflamed osseous tissue has opportunity afforded it to recruit.How long this process of repair may require for its completion varies greatly in different instances, and here and there we meet with a case in which, in consequence of the presence of pieces of dead bone too large to make their way to the surface, complete cure appears impossible.Happily, however, as experience has now amply proved, the great majority of these formerly hopeless cases, highly interesting to the poor creatures affected and to their relatives, though " not" yet "very interesting" to Mr. Spence, admit of complete cure, if patiently treated to the end with strict antiseptic care and rest.And here again I have to thank Mr. Spence for having, by his refer- ence to my cases left in the Infirmary, brought out incidentally the fact -I had almost said the glorious fact-recorded by Dr. Bishop in the number of the JOURNAL for the 3Ist ult., that under his good care almost all these types of hopelessness, as they might naturally be sup- posed to have been from the way in which they are alluded to by Mr. Spence, have been restored to health and usefulness.
Comments on "Effects of pericardial effusates of various conductivities on body-surface potential in dogs: documentation of the eccentric spheres model".
Authors: D H Spodick
Journal: Circulation Research (1985)

Kramer and colleagues have contributed important material on the effect of the composition of abnormal pericardial contents on electrocardiographic voltage (Kramer et al., 1984).They noted in passing that compression probably was not a part of the voltage reduction observed in fluids with conductivities either greater or less than that of blood.I wonder if the authors would care to comment on the work of Toney and Kolmen (1966), who used intrapericardial saline (among other substances) in animals with electrodes both on the endocardium and on the chest wall.Voltage reduction occurred in both electrodes during saline infusion at the point at which hemodynamic effects were first observed.The endocardial electrodes could not have been affected by any insulating effect of the physical presence of the fluid.However, their point was that both electrodes responded in tandem, and only after significant hemodynamic effects were observed.These remarks are not meant to criticize a nice study, but, rather, to request amplification.
Deaths of Two Patients Treated by Phenylbutazone
Authors: J. G. Benstead
Journal: BMJ (1953)

The parathyroid hormone (PTH)-1 receptor mediates the pathophysiological effects of PTH in hyperparathyroidism and PTH-related protein (PTHrP) in humoral hypercalcemia of malignancy. A PTH1 receptor antagonist may be of therapeutic utility in these disorders. We recently identified a novel antagonist, tuberoinfundibular peptide (7-39) [TIP(7-39)], derived from the likely endogenous ligand for the PTH2 receptor TIP39. In this study its in vitro profile is evaluated and compared with that of [d-Trp<sup>12</sup>,Tyr<sup>34</sup>]bPTH(7-34) and PTHrP(7-34), representing the two previously known structural classes of PTH1 receptor antagonists. TIP(7-39) binds with higher affinity (6.2 nM) to the PTH1 receptor than [d-Trp<sup>12</sup>,Tyr<sup>34</sup>]bPTH(7-34) (45 nM) and PTHrP(7-34) (65 nM) and displays a 5.5-fold greater PTH1/PTH2 receptor selectivity. TIP(7-39) does not stimulate cAMP accumulation via the PTH1 receptor [in a sensitive assay that detects the activity of the weak partial agonist [Nle<sup>8,18</sup>,Tyr<sup>34</sup>]bPTH(3-34)] and does not increase intracellular calcium. Schild analysis for TIP(7-39) was consistent with purely competitive antagonism of PTH(1-34)9s stimulation of cAMP accumulation (slope = 0.99 ± 0.24). The p<i>K</i><sub>B</sub> for TIP(7-39) (7.1 ± 0.3) was higher than that for [d-Trp<sup>12</sup>,Tyr<sup>34</sup>]bPTH(7-34) (6.5 ± 0.0) and PTHrP(7-34) (6.0 ± 0.1). Binding of<sup>125</sup>I-TIP(7-39) to the PTH1 receptor could be measured (<i>K</i><sub>D</sub> = 1.3 ± 0.1 nM,<i>B</i><sub>max</sub> = 1.3 ± 0.1 pmol/mg), whereas binding of<sup>125</sup>I-[Nle<sup>8,18</sup>,d-Trp<sup>12</sup>,Tyr<sup>34</sup>]bPTH(7-34) could not be detected. Kinetic analysis indicated that<sup>125</sup>I-TIP(7-39) dissociates much more slowly (<i>t</i><sub>1/2</sub> = 14 min) than [d-Trp<sup>12</sup>,Tyr<sup>34</sup>]bPTH(7-34) (13 s) and PTHrP(7-34) (9 s). The novel antagonist TIP(7-39) therefore displays a more favorable in vitro pharmacological profile than antagonists derived from PTH and PTHrP and may be useful for demonstrating the utility of PTH1 receptor antagonism in the treatment of hypercalcemia.
Survival in Angiosarcoma of the Breast-Reply
Authors: Richard L. Myerowitz
Journal: JAMA (1978)

In Reply.—  We agree with Dr Smoron that there was noobjectiveevidence of tumor response to chemotherapy in the case reported. We simply meant to indicate that the duration of survival of this patient for more than twice the mean survival reported in this diseaseprobablyindicated a response to chemotherapy.
Erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia and subsequent transformation to acute myeloid leukemia
Authors: Joan Etzell, Chuanyi M. Lu, L. Walden Browne, Endi Wang
Journal: American Journal of Hematology (2005)

Erythrophagocytosis by neutrophils is a rare phenomenon in myeloid malignancies, and its clinicopathologic significance is not fully understood. We report a unique case of erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia (CMML) and subsequent transformation to acute myeloid leukemia (AML). Review of multiple marrow samples, both pretreatment and post-treatment, demonstrated a correlation between percentage of dysplastic neutrophils and degree of erythrophagocytosis. Erythrophagocytosis was observed only in dysplastic forms of neutrophils. Post-transplant marrows with engraftment of donor cells showed no neutrophilic dysplasia or erythrophagocytosis. Possible mechanisms of neutrophilic erythrophagocytosis in myeloid malignancies are discussed. Am. J. Hematol. 79:340–342, 2005. © 2005 Wiley-Liss, Inc.
Minimally invasive treatment of a duodenal perforation associated with the EndoBarrier duodenal–jejunal bypass liner
Authors: Claudia Läßle, Katharina Laubner, Henning Schwacha, Jochen Seufert, Jodok Grueneberger, Andreas Fischer, W. Karcz, Ulrich Hopt, Goran Marjanovic, Simon Kuesters
Journal: Endoscopy (2014)

In order to establish less invasive therapies for treatment of excess bodyweight and obesity, a device that is placed endoscopically has been developed that mimics some of the anatomical and enteroendocrine effects of bariatric surgery. The EndoBarrier system (GI Dynamics, Lexington, Massachusetts, USA) is a duodenal–jejunal bypass liner (DJBL) that consists of a 60-cm long, impermeable fluoropolymer sleeve, which is fixed in the duodenal bulb by a nitinol anchor with barbs [1]. Initial clinical studies have revealed consistent efficacy and safety, with adverse effects described as moderate or mild [1] [2] [3] [4] [5]. In this case report a duodenal perforation associated with DJBL and its minimally invasive treatment were described.
A Hospital Program for the Detection and Registration of Abused and Neglected Children
Authors: Daniel S. Rowe, Martha F. Leonard, Margretta R. Seashore, Norman J. Lewiston, Frederic P. Anderson
Journal: New England Journal of Medicine (1970)

To facilitate early identification of abused and neglected children, a program has been developed in our medical center that includes a registry of such patients and a committee of staff members who are particularly qualified to deal with such problems. During the 18 months since the inception of the registry, 183 patients have been referred for evaluation. One hundred and eighteen patients have been listed in the registry: 37 have evidence of abuse, 69 of neglect, and 12 are thought to be at high risk of maltreatment. The program appears to have increased the level of staff awareness of these problems, promoted early identification and led to thorough investigation, active intervention and follow-up observation. A report to the Committee does not replace the mandatory formal report to the State Health or Welfare Department, and the Committee's tasks include assistance to the house officer in fulfillment of this responsibility.
Neurogenic Hypertension
Authors: A. C. Corcoran
Journal: JAMA (1960)

A 25-year-old man developed staphylococcal enteritis with severe shock during treatment of peritonitis with wide-spectrum antibiotics. The infection subsided during treatment with kanamycin (8.0 Gm. in four days). He subsequently developed nerve deafness, which has persisted. Associated with the onset of this were hypertension and tachycardia, highly responsive to guanethedine, and temporary impairment of 9th cranial nerve sensory functions and of carotid depressor reflexes bilaterally; these disturbances were ascribed to 9th nerve injury involving the moderator (buffer) nerves. Hypertension was transitory.
Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins.
Authors: J R Strahler, R Kuick, C Eckerskorn, F Lottspeich, B C Richardson, D A Fox, L M Stoolman, C A Hanson, D Nichols, H J Tueche
Journal: Journal of Clinical Investigation (1990)

By direct analysis of the polypeptide constituents of leukemic cells, we have previously detected several polypeptides that are restricted in their expression to acute lymphoblastic leukemia (ALL). In this study, we provide evidence that two polypeptides designated L2 and L4 are structurally related and represent novel markers for common ALL. Partial amino acid sequence analysis did not uncover differences between L2 and L4. The sequences obtained correspond to a previously cloned human gene designated hsp 27 that is expressed, following heat shock treatment, in a variety of cells. 32Pi incorporation studies indicate that L4 is an unphosphorylated form and L2 is a phosphorylated form of hsp27. The two forms were inducible by heat shock in leukemic and nonleukemic lymphoid cells. Thus, in acute leukemia, the common ALL subtype is uniquely characterized by the constitutive expression of a polypeptide that represents a major cellular phosphoprotein.
Metabolic effects of bicarbonate in the treatment of diabetic ketoacidosis.
Authors: P J Hale, J Crase, M Nattrass
Journal: BMJ (1984)

The effect of intravenous bicarbonate on the changes in intermediary metabolites during the initial treatment of diabetic ketoacidosis was examined in 16 patients. The results were compared with the changes seen in 16 patients receiving intravenous saline. Infusion of 150 mmol (mEq) bicarbonate significantly delayed the fall in blood lactate, lactate:pyruvate ratio, and total ketone bodies observed in the saline treated group. No difference in the rate of fall of blood glucose concentration was found. There is no metabolic indication for the use of intravenous bicarbonate in the treatment of diabetic ketoacidosis.
P105 Identifying missed opportunities for referral to pulmonary rehabilitation
Authors: SA Green, S Jones, AJ Poots, A Clark, C Howe
Journal: Thorax (2012)

<h3>Introduction and Objectives</h3> UK COPD standards require that patients are referred to pulmonary rehabilitation (PR) following hospitalisation for acute exacerbations of COPD (AECOPD). The Hillingdon pulmonary rehabilitation service established a "fast-track" route for patients admitted to Hillingdon Hospital with AECOPD in November 2011. Knowledge of current referral patterns and identification of missed opportunities can provide a strategy for improving access to PR services. <h3>Methods</h3> Data including residential postcode and registered GP were extracted for patients that were admitted to an acute hospital with AECOPD during a 6 month period (November 2011 to April 2012). Data were cross-referenced to referrals to the PR service. Admissions were mapped by residential postcode to provide a geographical distribution of patients that were referred to PR and those that were not. Admissions and subsequent referral status were analysed by GP practises; identifying practises with relatively high AECOPD admissions and low PR referrals <h3>Results</h3> There were 240 admissions during the 6 month period of analysis and 36 (15%) of the patients were referred to the pulmonary rehabilitation service via the "fast-track" route. Admissions mapped by residential postcode demonstrated a clustering of admissions in parts of the south of the borough, compared to the north. Although absolute numbers of PR referrals were similar in the north and south of the borough, there were far fewer in the south as a proportion of admissions. Analysis of admissions and PR referrals by GP practise identified a number of "high-value" practises that could be targeted to improve PR referrals. <h3>Conclusions</h3> Improving access and the uptake of PR remains challenging within the post-hospitalised AECOPD patient group. Analysing local data can generate an understanding of the bottlenecks in the system and develop strategies improving access and uptake. Transport is an often cited reason for patients declining referral. Analysis of geographical data can inform decisions on the location of community PR services. Identifying GP surgeries for targeted intervention to improve PR referral provides an opportunity to engage with GPs and support them in delivering high-quality, evidence based care.
An evolutionary interpretation of intelligence, creativity, and wisdom: A link between the evolution of organisms and the evolution of ideas
Authors: Robert J. Sternberg
Journal: Behavioral and Brain Sciences (2000)

I show that there is a link between the evolution of organisms and the evolution of ideas. In particular, if conformity is selected for, then mechanisms are needed so that “mutations” of ideas can occur. Creativity acts as a counter-force to conventional intelligence, so that ideas can develop that do not just elaborate existing paradigms, but oppose these paradigms. Sometimes oppositional ideas go too far, however, and wisdom acts as a force to bring the old and the new together. The dialectic thus integrates intelligence, creativity, and wisdom, with intelligence serving as thesis, creativity as antithesis, and wisdom as synthesis.
Lymphangiosarcoma in Postmastectomy Lymphedema: A Report of Six Cases in Elephantiasis Chirurgica
Authors: F. W. Stewart, N. Treves
Journal: CA A Cancer Journal for Clinicians (1981)

CA: A Cancer Journal for Clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care.
Speech Science: Acoustics in Speech
Authors: Lyle M. Sellers
Journal: JAMA (1962)

This is a delight to have at hand for the style and mode of presentation are completely original. The most noticeable innovations are an economy of words and a simplification of form and format. The entire book is presented in outline form. Each section of the outline is covered in from 1 to 3 or 4 brief sentences —each devoid of all ornamentation. As a means of refreshing one's knowledge, this is unsurpassed. It may, however, be questioned if the subject is so easily grasped by one who is covering the ground for the first time, and who is unacquainted with the word-economy presented. Not a word may be missed without danger of losing the sense of the portion covered. Thus, for one who is used to reading rapidly and intuitively selecting the salient words, the arrangement may present difficulties. But once the system used is grasped and proper reading
Relations between myocardial blood flow and postextrasystolic potentiation in epicardial and endocardial left ventricular regions early after coronary occlusion in dogs.
Authors: B Crozatier
Journal: Circulation (1982)

Postextrasystolic potentiation was studied during control and 5 minutes after coronary occlusion in epicardial regions of 12 open-chest dogs. Segmental behavior evaluated with ultrasonic crystals was correlated with regional myocardial blood flow (MBF) measured with radioactive microspheres. A similar correlation was found between the percentage of systolic shortening in postextrasystolic beats and MBF in epicardial (r = 0.64) and endocardial (r = 0.97) regions, although the scatter was much larger in the epicardium. The correlation was similar when segmental function was expressed as the area of the pressure-segment length loop. Three types of segments were described; completely ischemic segments (transmural MBF less than 5% of control), in which end-systolic length was larger than end-diastolic length after postextrasystolic potentiation; severely ischemic segments (5% less than or equal to transmural MBF less than 25% of control), in which the ischemic bulge during control beats was replaced by active shortening after premature ventricular complexes; and marginal segments (25% less than or equal to transmural MBF less than 100% of control), in which depressed shortening was enhanced close to control after a premature ventricular complex. These data reconcile conflicting studies, which did not consider similar degrees of ischemia and show a rapid loss of postextrasystolic potentiation in completely ischemic segments.
Recent Trends in Survival From Out-of-Hospital Cardiac Arrest in the United States
Authors: Paul S. Chan, Bryan McNally, Fengming Tang, Arthur Kellermann
Journal: Circulation (2014)

Despite intensive efforts over many years, the United States has made limited progress in improving rates of survival from out-of-hospital cardiac arrest. Recently, national organizations, such as the American Heart Association, have focused on promoting bystander cardiopulmonary resuscitation, use of automated external defibrillators, and other performance improvement efforts.Using the Cardiac Arrest Registry to Enhance Survival (CARES), a prospective clinical registry, we identified 70 027 U.S. patients who experienced an out-of-hospital cardiac arrest between October 2005 and December 2012. Using multilevel Poisson regression, we examined temporal trends in risk-adjusted survival. After adjusting for patient and cardiac arrest characteristics, risk-adjusted rates of out-of-hospital cardiac arrest survival increased from 5.7% in the reference period of 2005 to 2006 to 7.2% in 2008 (adjusted risk ratio, 1.27; 95% confidence interval, 1.12-1.43; P<0.001). Survival improved more modestly to 8.3% in 2012 (adjusted risk ratio, 1.47; 95% confidence interval, 1.26-1.70; P<0.001). This improvement in survival occurred in both shockable and nonshockable arrest rhythms (P for interaction=0.22) and was also accompanied by better neurological outcomes among survivors (P for trend=0.01). Improved survival was attributable to both higher rates of prehospital survival, where risk-adjusted rates increased from 14.3% in 2005 to 2006 to 20.8% in 2012 (P for trend<0.001), and in-hospital survival (P for trend=0.015). Rates of bystander cardiopulmonary resuscitation and automated external defibrillator use modestly increased during the study period and partly accounted for prehospital survival trends.Data drawn from a large subset of U.S communities suggest that rates of survival from out-of-hospital cardiac arrest have improved among sites participating in a performance improvement registry.
Patient Safety Efforts Should Focus on Medical Injuries
Authors: Peter M. Layde
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breast Cancer Studies Finally Published in New England Journal of Medicine
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Breast Cancer Studies Finally Published in New England Journal of Medicine Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 6, 15 March 1989, Pages 390–391, https://doi.org/10.1093/jnci/81.6.390 Published: 15 March 1989
What language is “mentalese”?
Authors: Dan I. Slobin
Journal: Behavioral and Brain Sciences (2002)

Carruthers’ “mentalese expressions” take the form of English sentences, thus suggesting an isomorphism between thought and language that ignores linguistic diversity. Furthermore, complex syntax is not the only linguistic means of combining information from various domain-specific modules into domain-general expressions, nor is such syntax the preferred means of encoding basic experiences in all languages. The analysis seems to rest on an unacknowledged version of linguistic determinism.