tbuckley/cabot-search huggingface dataset:
Pharmaceutical Desktop References
Authors: Richard P. Day
Journal: Annals of Internal Medicine (1994)

Letters1 May 1994Pharmaceutical Desktop ReferencesRichard P. Day, MDRichard P. Day, MDMadison Internal Medicine Associates; Madison, WI 53715Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-9-199405010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate Dr. LaPorta's additions. The Physician's Compendium of Drug Therapy has a brand-name orientation, incomplete package insert information, and advertisements. Another work of this type is Physician GenRX, which gives the verbatim Food and Drug Administration (FDA) package inserts listed in alphabetical order by generic name.Petrucco and colleagues are correct that AHFS Drug Information lacks a bibliography and includes in its appendix several types of investigational drugs. However, they are incorrect in stating that the USP Drug Information has no references or that Facts and Comparisons has no illustration section. Regarding the latter discrepancy, I suspect ... Author, Article, and Disclosure InformationAuthors: Richard P. Day, MDAffiliations: Madison Internal Medicine Associates; Madison, WI 53715 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1994Volume 120, Issue 9Page: 813-814KeywordsDrug informationDrug therapyDrugsFood and Drug AdministrationPharmacistsUnited States pharmacopeia ePublished: 15 August 2000 Issue Published: 1 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abortion Legislation-Reply
Authors: Aubrey Milunsky
Journal: JAMA (1983)

In Reply.—  Dr Lauinger attempted several arguments to refute our opposition to proposed federal enactments designed to outlaw abortion. First, she argued that a  of physicians would not be affected by this legislation. If Dr Lauinger opposes only legislation that would affect a majority of physicians,anyprocedure performed primarily by specialists would be in danger. Later, she maintained that 1.5 million abortions are performed yearly. Of course, all these procedures were performed by many physicians.  Dr Lauinger argued that most abortions are performed for social reasons. It is not clear what she means by this. If she means that most women's decisions to abort are frivolous, we simply disagree. What few data exist indicate that women who choose to abort find the decision difficult to make and that a substantial number change their minds at least once before reaching a clinic.1What can be said with certainty
Very Low Calorie Diets: Their Efficacy, Safety, and Future
Authors: THOMAS A. WADDEN
Journal: Annals of Internal Medicine (1983)

Very low calorie diets used to treat moderate and severe obesity produce average weight losses of 20 kg in 12 weeks. This paper reviews the development of very low calorie diets from research on fasting in the late 1950s and examines data on the amount of dietary protein needed to achieve positive nitrogen balance. The desirability of including carbohydrate in the diet, the choice of protein sources (formula versus animal protein), and the anorectic value of ketosis are discussed, as are patient selection and the clinical course of the diet. As contrasted to the earlier "liquid protein" diets that were associated with at least 60 deaths, very low calorie diets of high-quality protein appear safe when limited to 3 months or less under careful medical supervision. Evidence of this safety is provided by the results of 24-hour Holter monitoring and the fact that no diet-related fatalities have been reported in over 10 000 cases. The major problem to be resolved is the maintenance of the large weight losses achieved with these diets.
Prenatal Air Pollution Exposure and Newborn Blood Pressure
Authors: Lenie van Rossem, Sheryl L. Rifas-Shiman, Steven J. Melly, Itai Kloog, Heike Luttmann-Gibson, Antonella Zanobetti, Brent A. Coull, Joel D. Schwartz, Murray A. Mittleman, Emily Oken, Matthew W. Gillman, Petros Koutrakis, Diane R. Gold
Journal: Environmental Health Perspectives (2015)

Air pollution exposure has been associated with increased blood pressure in adults.We examined associations of antenatal exposure to ambient air pollution with newborn systolic blood pressure (SBP).We studied 1,131 mother-infant pairs in a Boston, Massachusetts, area pre-birth cohort. We calculated average exposures by trimester and during the 2 to 90 days before birth for temporally resolved fine particulate matter (≤ 2.5 μm; PM2.5), black carbon (BC), nitrogen oxides, nitrogen dioxide, ozone (O3), and carbon monoxide measured at stationary monitoring sites, and for spatiotemporally resolved estimates of PM2.5 and BC at the residence level. We measured SBP at a mean age of 30 ± 18 hr with an automated device. We used mixed-effects models to examine associations between air pollutant exposures and SBP, taking into account measurement circumstances; child's birth weight; mother's age, race/ethnicity, socioeconomic position, and third-trimester BP; and time trend. Estimates represent differences in SBP associated with an interquartile range (IQR) increase in each pollutant.Higher mean PM2.5 and BC exposures during the third trimester were associated with higher SBP (e.g., 1.0 mmHg; 95% CI: 0.1, 1.8 for a 0.32-μg/m3 increase in mean 90-day residential BC). In contrast, O3 was negatively associated with SBP (e.g., -2.3 mmHg; 95% CI: -4.4, -0.2 for a 13.5-ppb increase during the 90 days before birth).Exposures to PM2.5 and BC in late pregnancy were positively associated with newborn SBP, whereas O3 was negatively associated with SBP. Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.
Comment: Predictability of Survival in the Individual Patient With Lung Cancer
Authors: Philip Rubin
Journal: JAMA (1966)

The main hope for survival rests in the patient who has a resectable tumor without overt evidence of regional or distant metastases. Cliffton classifies this type of malignancy as stage I and notes that the lesion is probably resectable with a good chance for cure. In analyzing the figures, only one of five in this category manage to survive five years. This is still a poor result. Are there any specific prognostic factors that determine longterm survival even in this highly selected group?  The majority of reports indicate that there is no relationship between survival and age, sex, race, or duration of symptoms. Of pertinence is a recent report by Reinhoff et al (1965) 14 who studied the pathological specimens of resected lungs. Factors which appeared significant to long-term survival were cell type and blood-vessel invasion . Bronchiolar carcinoma carries a much better prognosis (87% survival) than adenocarcinoma and well differentiated
Hilar Adenopathy in Aspergillosis
Authors: Howard Mann
Journal: Annals of Internal Medicine (1992)

Letters15 February 1992Hilar Adenopathy in AspergillosisHoward Mann, MDHoward Mann, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-4-346 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In their case report, Hantsch and Tanus (1) describe hilar adenopathy in association with allergic bronchopulmonary aspergillosis. As a radiologist, I am concerned about their analysis of the radiographs presented.I believe the perihilar opacities shown in Figure 1 (1) are typical of dilated, mucus-filled central bronchi. The investigators state that "subtle findings consistent with central bronchiectasis were detected on retrospective evaluation of a computed tomographic scan of the chest." The opacities shown would be evident on a computed tomographic examination, which would also permit the distinction between dilated bronchi and lymph node enlargement. Unfortunately, appropriate images...Reference1. HantschTanus CT. Allergic bronchopulmonary aspergillosis with adenopathy. Ann Intern Med. 1991;115:546-7. LinkGoogle Scholar1. HantschTanus CT. Allergic bronchopulmonary aspergillosis with adenopathy. Ann Intern Med. 1991;115:546-7. LinkGoogle Scholar1. HantschTanus CT. Allergic bronchopulmonary aspergillosis with adenopathy. Ann Intern Med. 1991;115:546-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Howard Mann, MDAffiliations: LDS Hospital Salt Lake City, UT 84143 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1992Volume 116, Issue 4Page: 346-347KeywordsAspergillosisBronchiBronchiectasisComputed axial tomographyLymph nodesRadiologistsThorax ePublished: 1 December 2008 Issue Published: 15 February 1992 PDF downloadLoading ...
Gold Therapy in Rheumatoid Arthritis
Authors: P. Ellman, J. S. Lawrence, G. P. Thorold
Journal: BMJ (1940)

ally occurring epidemic disease of rodents, and sometimes arises spontaneously in laboratory animals. It can be transmitted from one animal to another artificially by injecting fluid from the joints or internal organs of infected animals into the joints of the healthy animals. Collier (1939) found that injection of such gold com pounds as aurodetoxin and solganal B into rats protects them against experimental infection. Findlay, Mackenzie, and MacCallum (1940) have shown that infectious arthritis of rodents is due to a pleuropneumonia type of organism. Xike Collier, they were able to show that gold compounds would protect against the inoculated disease, solganal B being the most efficacious. Arsenical compounds also had a prophylactic action, but not so great as that of gold. No effect was produced by any of the sulphon amide derivatives. These results are the most suggestive, as Swift and Brown (1939) claim to have isolated a pleuro pneumonia-like organism from human cases of acute rheumatism.
TCT-77 Initial and Mid-Term Angiographic Outcomes of Septal Channel Perforation Related to Retrograde Recanalization for Chronic Total Occlusions
Authors: Hiroyuki Tanaka, Kazushige Kadota, Seiji Habara, Yasushi Fuku, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2012)
No association between MDM2 SNP309 promoter polymorphism and basal cell carcinoma of the skin
Authors: S. Wilkening, K. Hemminki, P. Rudnai, E. Gurzau, K. Koppova, A. Försti, R. Kumar
Journal: British Journal of Dermatology (2007)

The MDM2 oncoprotein promotes cell survival and cell cycle progression by inhibiting the p53 tumour suppressor protein. Further, overexpression of the MDM2 gene can inhibit DNA double-strand break repair in a p53-independent manner. Recent studies have shown that a single nucleotide polymorphism (SNP) in the intronic promoter region of MDM2 (called SNP309) can significantly change the expression of MDM2 and thereby suppress the p53 pathway. This SNP was also found to be associated with the onset and risk of different cancer types. Basal cell carcinoma of the skin (BCC) is one of the most common neoplasms in the world. BCC development is associated with environmental factors (especially sun exposure) as well as heritable factors.The present case-control study investigated the association of the MDM2 SNP309 with the risk and the age at onset of BCC. Methods Data from 509 individuals affected by BCC and 513 healthy controls were genotyped with TaqMan polymerase chain reaction.Cases and controls showed a similar genotype distribution and the SNP did not modify the age at onset of BCC.These results suggest that the MDM2 SNP309 alone affects neither the risk nor the age at onset of BCC.
Minimally invasive surgery 2006 - 2007
Authors: J. Jin, M. Rosen, J. Ponsky
Journal: Endoscopy (2008)

Minimally invasive surgery is fast becoming the preferred treatment option for many surgical diseases. Furthermore, innovative surgeons around the world are continually pushing the boundaries of minimally invasive surgery. Five articles published in 2006 - 2007 that were considered to have a high impact for minimally invasive surgery are reviewed here.
The American Health Care System and the 1992 Election
Authors: George D. Lundberg
Journal: JAMA (1992)

As every American reader knows, the United States is about to exercise its quadrennial opportunity to elect a President and Vice President for the next 4 years, the entire House of Representatives (435 positions) for the next 2 years, and 34 of 100 Senators for the next 6 years. No US election in my memory has seemed to be more important to the medical and health care community (and to all of us as patients) than this one on November 3,1992. It is distressing that health care has become so politicized, but it is immensely gratifying to note that the importance of health as an issue at this time has become recognized by nearly all.  Health care in the US can be wonderful, but our health care system is in dire need of change. There is abundant scientific evidence to support both of these statements.  During the past 3 years,
Pigmented wart showing fibrillar intracytoplasmic inclusion bodies
Authors: Y. Hagari, N. Yamada, M. Mihara
Journal: British Journal of Dermatology (2003)

Sir, Pigmented wart is a recently described type of wart associated with human papillomavirus (HPV) types 4, 60 or 65.1 It is characterized clinically by brown to black nodules and histopathologically by melanin blockade melanocytes and intracytoplasmic inclusion bodies. The inclusion bodies were found as eosinophilic homogeneous intracytoplasmic bodies in keratinocytes.1 On the other hand, a new type of nonpigmented viral wart with peculiar fibrillar intracytoplasmic inclusion bodies was recently described.2 The causal HPV type was thought to be a new HPV type that had not yet been characterized. We describe a patient with a pigmented wart showing fibrillar intracytoplasmic inclusion bodies. A 61‐year‐old woman presented with an asymptomatic brown nodule on her right hand. She had noticed a tiny, dark‐brown nodule 2 years previously. The nodule then gradually enlarged with the colour fading into brown. On examination, a brown hyperkeratotic nodule, measuring 4 mm in diameter, was observed on the ulnar lateral aspect of her right hand. The nodule had a rough surface on which dark brown dots were observed (Fig. 1a). The appearance of the nodule was that of a common wart except for its colour.
Retained common bile duct stones after endoscopic sphincterotomy: temporary and longterm treatment with biliary stenting.
Authors: D G Maxton, D E Tweedle, D F Martin
Journal: Gut (1995)

Basket extraction after endoscopic sphincterotomy failed to clear the bile ducts immediately in 85 (30%) of 283 consecutive patients with common bile duct stones. Temporary biliary drainage was established by the insertion of a single 7 Fr double pigtail stent before further planned endoscopic attempts at stone removal. In 84 patients (21 male: 63 female, mean age 77 years) this measure relieved biliary obstruction, mean serum bilirubin falling from 101 to 18 umol/l by the time of the second endoscopic retrograde cholangiopancreatography. Six patients died from non-biliary causes with temporary stents in situ. Common bile duct stone extraction was achieved endoscopically in 50 of the remaining 79 patients after a mean of 4.3 months (range 1-12), 34 (68%) requiring only one further procedure. Three patients were referred for biliary surgery. Single stents were also effective for longterm biliary drainage in the remaining 26 elderly patients with unextractable stones. The main biliary complication of stenting was 13 episodes of cholangitis but all except one responded to medical treatment and early stent exchange. If common bile duct stones remain after endoscopic sphincterotomy, a single 7 Fr double pigtail stent is effective and safe for temporary biliary drainage before further endoscopic attempts at duct clearance and for longterm biliary drainage especially in the old and frail.
H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury.
Authors: D K Kim, L Zhang, V J Dzau, R E Pratt
Journal: Journal of Clinical Investigation (1994)

Vascular smooth muscle cell migration, proliferation, and differentiation are central to blood vessel development. Since neointimal formation after vascular injury may require the reexpression of a smooth muscle developmental sequence, we examined the expression of H19, a developmentally regulated gene, in rat blood vessels. Expression of the H19 gene is associated with the differentiation process that takes place during development of many tissues. Consistent with this, H19 was highly expressed in the 1-d-old rat aorta but was undetectable in the adult. H19 transcripts were only minimally detected in uninjured carotid artery but were abundant at 7 and 14 d after injury and were localized by in situ hybridization, primarily to the neointima. H19 transcript were undetectable in proliferating neointimal cells in culture but became highly abundant in postconfluent, differentiated neointimal cells. H19 transcripts were only minimally expressed in adult medial smooth muscle cells grown under the identical conditions. Thus, H19 may play an important role in the normal development and differentiation of the blood vessel and in the phenotypic changes of the smooth muscle cells, which are associated with neointimal lesion formation. The vascular injury model may be a useful system to use in examining the function of H19.
Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor–Dependent and –Independent Mechanisms
Authors: Shirya Rashid, Hagai Tavori, Patrick E. Brown, MacRae F. Linton, Jane He, Ilaria Giunzioni, Sergio Fazio
Journal: Circulation (2014)

Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabolism of triglyceride-rich apolipoprotein B (apoB) lipoproteins, another important coronary heart disease risk factor. Here, we studied the effects of physiological levels of PCSK9 on intestinal triglyceride-rich apoB lipoprotein production and elucidated for the first time the cellular and molecular mechanisms involved.Treatment of human enterocytes (CaCo-2 cells) with recombinant human PCSK9 (10 μg/mL for 24 hours) increased cellular and secreted apoB48 and apoB100 by 40% to 55% each (P<0.01 versus untreated cells), whereas short-term deletion of PCSK9 expression reversed this effect. PCSK9 stimulation of apoB was due to a 1.5-fold increase in apoB mRNA (P<0.01) and to enhanced apoB protein stability through both LDLR-dependent and LDLR-independent mechanisms. PCSK9 decreased LDLR protein (P<0.01) and increased cellular apoB stability via activation of microsomal triglyceride transfer protein. PCSK9 also increased levels of the lipid-generating enzymes FAS, SCD, and DGAT2 (P<0.05). In mice, human PCSK9 at physiological levels increased intestinal microsomal triglyceride transfer protein levels and activity regardless of LDLR expression.PCSK9 markedly increases intestinal triglyceride-rich apoB production through mechanisms mediated in part by transcriptional effects on apoB, microsomal triglyceride transfer protein, and lipogenic genes and in part by posttranscriptional effects on the LDLR and microsomal triglyceride transfer protein. These findings indicate that targeted PCSK9-based therapies may also be effective in the management of postprandial hypertriglyceridemia.
Cocoa Intake and Blood Pressure—Reply
Authors: Dirk Taubert, Norma Jung, Renate Roesen
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification and Treatment of Cystic Fibrosis-Related Diabetes: A survey of current medical practice in the U.S
Authors: Holley F Allen, Elizabeth C Gay, Georgeanna J Klingensmith, Richard F Hamman
Journal: Diabetes Care (1998)

To describe physicians' attitudes and practices in screening for and treating abnormalities in glucose homeostasis in cystic fibrosis (CF) patients and to test the hypotheses that guidelines for screening for CF-related diabetes (CFRD) are not followed at most centers and that screening and treatment vary by the care provider's background.This cross-sectional survey included three groups of physicians: 1) 593 members of the Lawson Wilkins Pediatric Endocrine Society (LWPES), 2) 462 members of the pediatric assembly of the American Thoracic Society (ATS), and 3) 194 directors of cystic fibrosis centers (CFD). A mailed questionnaire was used for the survey.The overall response rate was 67%. Of these, 224 LWPES, 143 ATS, and 135 CFD physicians reported actively seeing CF patients. About two-thirds of CF physicians (ATS and CFD) reported routine screening for impaired glucose tolerance (IGT) in asymptomatic CF patients; a random glucose is most often used (60%), followed by HbA1c (50%), urine glucose (44%), fasting glucose (21%), and oral glucose tolerance test (2%). Only 40% of LWPES physicians reported intervening for stress-induced hyperglycemia, but 61% reported use of insulin for persistent IGT. Management of CFRD was similar for all groups; most physicians used insulin (91%). LWPES recommended more intensive glucose testing and nutritional guidelines than did ATS/CFD (P < 0.0001). LWPES reported less concern about risks of diabetes complications (P < 0.0001) and the importance of minimizing burdensome interventions (P < 0.01). All groups considered weight management a top priority.Screening for IGT is not routinely done in CF patients and screening tests vary. Greater agreement exists on methods of treating patients with persistent IGT or CFRD, although goals and aggressiveness of treatment vary with the provider's background. A consensus conference is recommended.