tbuckley/cabot-search huggingface dataset:
Cimetidine in Secondary Hyperparathyroidism
Authors: J. KOVARIK
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 March 1982Cimetidine in Secondary HyperparathyroidismJ. KOVARIK, M.D., H. GRAF, M.D., W. WOLOSZCZUK, PH.D., H.K. STUMMVOLL, M.D.J. KOVARIK, M.D.Search for more papers by this author, H. GRAF, M.D.Search for more papers by this author, W. WOLOSZCZUK, PH.D.Search for more papers by this author, H.K. STUMMVOLL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-379_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After anecdotal reports on a decrease of immunoreactive paraphyroid hormone (PTH) levels due to the administration of cimetidine in primary hyperparathyroidism (1,2), therapeutic trials of this agent in patients with secondary hyperparathyroidism have reached conflicting results (3-5). Data on this issue still are too few to draw definite conclusions, and the ratio of beneficial versus no effects of cimetidine on hyperparathyroidism in uremic patients is 12:5, as calculated from the recent literature (3-5). We studied the effect of this H2-receptor blocking agent in a series of patients on chronic intermittent hemodialysis.Twenty-eight patients on chronic intermittent hemodialysis...References1. SHERWOODREINHARDGARCIA JDM. Does cimetidine inhibit parathyroid hormone secretion? N Engl J Med. 1979;300:200. Letter. CrossrefMedlineGoogle Scholar2. SIMONSTIEHLFEURLEKOMERELL BAGB. Erfolgreiche Ulcusbehandlung mit Cimetidin bei einem Patienten mit primarem Hyperparathyreoidismus. Med Klin. 1978;73:1513-6. MedlineGoogle Scholar3. JACOBLANIERCANTERBURYBOURGOIGNIE ADJJ. Reduction of cimetidine of serum parathyroid hormone levels in uremic patients. N Engl J Med. 1980;302:671-4. CrossrefMedlineGoogle Scholar4. VANHERWEGHEMBURGEOISFUSS JNM. Cimetidine and parathyroid hormone levels. N Engl J Med. 1980;303:395-6. Letter. CrossrefMedlineGoogle Scholar5. BEEHLERBECKNERROSENQUISTSHANKEL CJRS. Parathyroid hormone suppression by cimetidine in the uremic patient. Ann Intern Med. 1980;93:840-1. LinkGoogle Scholar6. MARTINHRUSKAFREITAGBELLORIN-FONTKLAHRSLATOPOLSKY KKJESE. Clinical utility of radioimmunoassays for parathyroid hormone. Mineral Electrolyte Metab. 1980;3:283-90. Google Scholar7. MALLETTE L. Sensitivity of the entire antibovine parathyroid hormone serum 211/32 to synthetic fragments of human parathyroid hormone. J Clin Endocrinol Metab. 1980;50:201-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. KOVARIK, M.D.; H. GRAF, M.D.; W. WOLOSZCZUK, PH.D.; H.K. STUMMVOLL, M.D.Affiliations: University of Vienna and Ludwig Boltzmann-Institute for Clinical Endocrinology Vienna Austria PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1982Volume 96, Issue 3Page: 379-379KeywordsHormonesHyperparathyroidism ePublished: 1 December 2008 Issue Published: 1 March 1982 PDF downloadLoading ...
Looking for landmarks
Authors: T Smith
Journal: BMJ (1994)

One of the satisfactions I gained from this year's summer cruise along the southern coast of Norway was getting to know the landmarks - the lighthouses, the stone towers built on isolated rocky islets, the patch of rock painted white at Risor so that it is visible 20 miles away. These are landmarks in sailors' terms, distinctive features which enable them to recognise whereabouts they are when they reach the coast after a long voyage.

Landmark as a metaphor in medicine has come to mean advances that represent a substantial change in knowledge or technique, and this month I am trying to decide the highlights of the past five years. The growth of …
Structures and Function of Immunoglobulins and Some Disorders of Synthesis.
Authors: Edward C. Franklin
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Structures and Function of Immunoglobulins and Some Disorders of Synthesis.Edward C. Franklin, M.D.Edward C. Franklin, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-853_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAll immunoglobulins consist of two types of polypeptide chains (heavy and light chains) that appear to be under separate genetic control. Certain neoplastic disorders of plasma cells and lymphocytes are accompanied by the production of homogeneous immunoglobulins. Among these disorders are myeloma, macroglobulinemia, and the group of heavy chain diseases. Study of the proteins produced has provided clear insights into the biosynthesis and assembly of immunoglobulins, has uncovered evidence of unbalanced synthesis of heavy and light chains, and has demonstrated the existence of deletions in some of the proteins. Not infrequently these proteins can be shown to possess antibody activity,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 853-853KeywordsBiosynthesisGeneticsLymphocytesMyelomaPlasma cellsPolypeptidesProtein synthesisProteins Issue Published: 1 May 1972 PDF downloadLoading ...
Response to Wolever
Authors: Marion J. Franz, John P. Bantle
Journal: Diabetes Care (2002)

We thank M.S. Wolever (1) for his letter asking about the process used to develop the American Diabetes Association (ADA) nutrition principles and recommendations. As with all ADA technical reviews and position statements, the process is determined by the ADA as outlined in the ADA Clinical Practice Recommendations 2002 introduction (2), which is used for all new and revised ADA position statements. Members of the task force reviewed the literature with emphasis on …
Splenic T Zone Development Is B Cell Dependent
Authors: Vu N. Ngo, Richard J. Cornall, Jason G. Cyster
Journal: The Journal of Experimental Medicine (2001)

The factors regulating growth and patterning of the spleen are poorly defined. We demonstrate here that spleens from B cell-deficient mice have 10-fold reduced expression of the T zone chemokine, CCL21, a threefold reduction in T cell and dendritic cell (DC) numbers, and reduced expression of the T zone stromal marker, gp38. Using cell transfer and receptor blocking approaches, we provide evidence that B cells play a critical role in the early postnatal development of the splenic T zone. This process involves B cell expression of lymphotoxin (LT)alpha1beta2, a cytokine that is required for expression of CCL21 and gp38. Introduction of a B cell specific LTalpha transgene on to the LTalpha-deficient background restored splenic CCL21 and gp38 expression, DC numbers, and T zone size. This work also demonstrates that the role of B cells in T zone development is distinct from the effect of B cells on splenic T cell numbers, which does not require LTalpha1beta2. Therefore, B cells influence spleen T zone development by providing: (a) signals that promote T cell accumulation, and: (b) signals, including LTalpha1beta2, that promote stromal cell development and DC accumulation. Defects in these parameters may contribute to the immune defects associated with B cell deficiency in mice and humans.
Aplastic anemia in a petrochemical factory worker.
Authors: Y M Baak, B Y Ahn, H S Chang, J H Kim, K A Kim, Y Lim
Journal: Environmental Health Perspectives (1999)

A petrochemical worker with aplastic anemia was referred to our hospital. He worked in a petroleum resin-producing factory and had been exposed to low-level benzene while packaging the powder resin and pouring lime into a deactivation tank. According to the yearly environmental survey of the working area, the airborne benzene level was approximately 0.28 ppm. Exposure to benzene, a common chemical used widely in industry, may progressively lead to pancytopenia, aplastic anemia, and leukemia. The hematotoxicity of benzene is related to the amount and duration of exposure. Most risk predictions for benzene exposures have been based on rubber workers who were exposed to high concentrations. In the petroleum industry, the concentration of benzene is relatively low, and there are disputes over the toxicity of low-level benzene because of a lack of evidence. In this paper we report the case of aplastic anemia induced by low-level benzene exposure.
Fever of Unknown Origin
Authors: Karl M. Morgenstein
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Katz and Fauci presented a case report of<i>Nocardia asteroides</i>sinusitis (238:2397, 1977), and William R. Barclay, MD, applauded the article on the editorial page (238:2404, 1977). Frankly, I found it distressing that a 39-year-old woman underwent a "million dollar work-up" including an exploratory laparotomy and other invasive diagnostic procedures over a period of a year to establish a diagnosis of sinusitis. I hasten to say that the finding of<i>N asteroides</i>in the sinus is an interesting and reportable finding. My consternation is with the fact that a fever of unknown origin was sought everywhere in the body before the sinuses were examined. Evaluation by an otolaryngologist or even a simple x-ray examination of the sinuses would most likely have established a diagnosis at the outset. What we have here is the predominance of the advanced technological approach. Indeed, Dr Barclay's editorial ended with the following
BMA asks government to support campaign for more consultants
Authors: Lynn Eaton
Journal: BMJ (2008)

The BMA has launched a campaign to call for more consultants in the NHS, after a survey of the royal colleges shows a growing shortfall in the number of specialists needed to meet demand in many clinical areas.

The number of consultants needs to rise in emergency medicine, trauma, intensive care, acute medicine, paediatrics, and obstetrics, says the BMA report.

The BMA says that mounting evidence also shows the need to increase the number of consultants above existing expansion to ensure that patients receive the highest possible level of care.

“It has become clear that many . . . NHS employers in the recent …
Hypokalemia after treatment with duogastrone (carbenoxolone).
Authors: M. Swallow
Journal: BMJ (1969)

BRITIShilarity and movement (presumably includ- ing eye movement) during the compression phase due to the combined effects of warmth and nitrogen narcosis, thus assisting the flow of nitrogen-laden tears between the lens and cornea, while during decompression the chamber was, as is usual, rather cold and foggy, with the subjects relatively immobile, thus minimizing any flow of tears which might have helped to wash out the nitrogen.As the other eye was only slightly affected, it must be presumed that there was a difference in the fit, and hence in the flow of tears under the two lenses, causing either less absorption or better elimination of gas from the other eye.-Iam, etc.,
Atypical Bisphosphonate-Associated Subtrochanteric and Femoral Shaft Stress Fractures
Authors: Stephan Probst, Rajan Rakheja, Jerry Stern
Journal: Clinical Nuclear Medicine (2013)

A 69-year-old woman presented with a spontaneous right subtrochanteric hip fracture. Pan-imaging following orthopedic repair failed to identify a primary malignancy to explain the presumed pathologic basis for this fracture. The patient then underwent bone scintigraphy and SPECT/CT which showed mild uptake in multifocal endosteal thickening of the lateral left femoral diaphysis, diagnostic of bisphosphonate-associated femoral shaft stress fractures, but no evidence of metastatic bone disease. Atypical bisphosphonate-associated subtrochanteric and femoral shaft stress fractures have a fairly specific appearance on bone scintigraphy, and nuclear medicine physicians should be aware of this relatively infrequent emerging pathology.
Chemotherapy only compared to chemotherapy followed by transplantation in high risk myelodysplastic syndrome and secondary acute myeloid leukemia; two parallel studies adjusted for various prognostic factors
Authors: M Oosterveld, P Muus, S Suciu, C Koller, G Verhoef, B Labar, P Wijermans, C Aul, D Fière, D Selleslag, R Willemze, A Gratwohl, A Ferrant, F Mandelli, J Cortes, T de Witte, E Estey
Journal: Leukemia (2002)
Delineation of the functional capacity of human neonatal lymphocytes.
Authors: J B Splawski, D F Jelinek, P E Lipsky
Journal: Journal of Clinical Investigation (1991)

Neonatal T cell-B cell collaboration was investigated utilizing a system of T cell-dependent polyclonal B cell activation and Ig secretion. In this system, T cells activated by immobilized anti-CD3 provide a potent stimulus for Ig production by adult lymphocytes. By contrast, anti-CD3 stimulation of cord blood lymphocytes generated minimal numbers of Ig-secreting cells. Ig production by neonatal lymphocytes was enhanced by the addition of Staphylococcus aureus or secreted factors from mitogen-stimulated adult T cells. Supplementation with IL-2 resulted in the production of large amounts of IgM and small amounts of IgG and IgA, with less Ig produced than by comparable cultures of adult lymphocytes. Neonatal T cells proliferated and produced IL-2 in response to immobilized anti-CD3, and supported B cell proliferation and Ig secretion by adult B cells, although not as effectively as adult T cells. Supernatants from activated neonatal T cells were markedly limited in their capacity to support Ig production by adult B cells. Neonatal B cells could be induced to differentiate in response to anti-CD3-stimulated adult T cells. However, the amounts of IgG and IgA secreted were small compared to adult levels. These studies indicate a relative, but not absolute, functional deficiency of both neonatal B and T cells.
P2-008: Influence of common glutathion-S-transferase and DNA repair variant alleles on p53 function: relation to lung cancer risk and progression
Authors: Polina Gervas, Natalia Smetannikova, Maria Vasilieva, Nadejda Cherdyntseva, Valentina Belyavskaya, Aleksey Dobrodeev, Sergey Tusikov, Natalia Sevostianova, Alla Dmitrieva
Journal: Journal of Thoracic Oncology (2007)
Can Hair Turn White Overnight?
Authors: Fred Rosner
Journal: JAMA (1981)

To the Editor.—  In response to a physician's inquiry about the spontaneous development of localized poliosis (whitening of the hair), the consultant (1981:246;284) cites several common causes, including radiation therapy, alopecia areata, severe dermatitis, and vitiligo. Two additional possibilities are described in ancient Hebrew writings.  The Babylonian Talmud (Tractate Berachoth folios 27b and 28a) relates that when the wise and sagacious Rabbi Eleazar ben Azariah was asked whether or not he would consent to become head of the rabbinical academy, his wife said to him: You have no white hair. He was 18 years  on that day, and a miracle was wrought for him as 18 rows of hair on his beard turned white. That is why he said: Behold, I am like seventy years old and did not simply say seventy years old.  The commentator Rabbi Shlomo ben Yitzchok, popularly known as Rashi, states that Rabbi Eleazar ben
Polymorphism distribution of Int13, Int22, and St14 VNTRs in a Mexican population and their application in carrier diagnosis of hemophilia A
Authors: Rafael Martínez Gallegos, Herminia Benítez Aranda, Carmen Navarrete, Rosenda Peñaloza Espinoza, Fabio Salamanca Gómez, Diego Arenas Aranda
Journal: American Journal of Hematology (2004)

Variable nucleotide tandem repeats (VNTR) Int13, Int22, and St14 were analyzed to determine polymorphic distribution in normal individuals from Mexico's central region and their efficacy in detecting hemophilia A carriers. Polymerase chain reaction (PCR) was carried out on 166 X chromosomes from unrelated Mexicans, and the same method was applied to detect carriers in hemophilia A families. Screening revealed the existence of at least eight different alleles for Int13, 4 alleles for Int22, and 10 alleles for St14. Their heterozygosity rates were 41.3%, 52.6%, and 83%, respectively. Compared to Caucasians, the Mexican population showed a markedly low heterozygosity rate for the Int13 marker. However, Int22 showed a heterozygosity that was similar to Turkish and Chinese populations. The St14 marker was the most informative in carrier diagnosis, and a new 680-bp allele not previously reported was detected. Carrier diagnosis was performed in 39 women from eight different hemophilia A families. Fifteen (38%) females were not carriers, 16 (41%) females were carriers, and 8 (21%) were homozygous. Determination of polymorphisms in VNTR markers revealed that St14 was the most useful for hemophilia A carrier detection in Mexico.
Trastuzumab in the Treatment of Advanced Non–Small-Cell Lung Cancer: Is There a Role?
Authors: Gregory Kalemkerian
Journal: Journal of Clinical Oncology (2005)

I was interested to read the report of Carter et al of a conservative management strategy for early prostate cancer, 1 and I agree with the authors that the term "watchful waiting" does not accurately describe their strategy.Given the overdiagnosis and lead-time bias associated with prostate-specific antigen (PSA) screening, 2 the natural history of prostate cancer following diagnosis is now far more favorable than it was in the pre-PSA era, making a conservative management strategy an attractive option for many patients.However, clinicians and patients need to understand the important distinctions between the different conservative strategies now available.The term watchful waiting was widely used during the pre-PSA era to describe a policy of observation with palliative treatment for symptomatic cancer progression.Such a policy remains appropriate for patients who, by virtue of age and comorbidities, have a relatively short life expectancy and do not have a radical treatment option.A second, and quite distinct, approach to favorable-risk early prostate cancer is to determine the need for radical treatment based on biochemical or histologic evidence of disease progression during close monitoring.The aim of this approach is to target curative treatment to the minority of patients who need it, so that the majority are spared the side effects of unnecessary treatment.This strategy was first described by Richard Choo et al as, "watchful observation with selective delayed intervention." 3At the Royal Marsden Hospital, we use the term "active surveillance" to describe this strategy. 4 These initial studies have demonstrated the feasibility of this approach, which offers patients a realistic hope of avoiding treatment side effects without detriment to their survival.Active surveillance requires a clear definition of the indications for radical treatment (usually based on PSA doubling time and the results of repeat biopsies), together with a commitment to the policy from both patient and clinician.If these are lacking, the result will be "temporarily deferred therapy," as described by Carter et al, in which men with early prostate cancer who are almost inevitably going to have radical treatment, choose to delay such therapy. 1
Genital recurrent infection occurring 6 months after meningitis due to the same herpes simplex virus type 2 (HSV-2) strain evidenced by restriction endonuclease analysis
Authors: C. Venot, A. Beby, A. Bourgoin, G. Giraudeau, B. Becq-Giraudon, G. Agius
Journal: Journal of Infection (1998)
Association of intron phases with conservation at splice site sequences and evolution of spliceosomal introns
Authors: M. Long, M. Deutsch
Journal: Molecular Biology and Evolution (1999)

How exon-intron structures of eukaryotic genes evolved under various evolutionary forces remains unknown. The phases of spliceosomal introns (the placement of introns with respect to reading frame) provide an opportunity to approach this question. When a large number of nuclear introns in protein-coding genes were analyzed, it was found that most introns were of phase 0, which keeps codons intact. We found that the phase distribution of spliceosomal introns is strongly correlated with the sequence conservation of splice signals in exons; the relatively underrepresented phase 2 introns are associated with the lowest conservation, the relatively overrepresented phase 0 introns display the highest conservation, and phase 1 introns are intermediate. Given the detrimental effect of mutations in exon sequences near splice sites as found in molecular experiments, the underrepresentation of phase 2 introns may be the result of deleterious-mutation-driven intron loss, suggesting a possible genetic mechanism for the evolution of intron-exon structures.
CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks
Authors: Karen E. Anderson, Keith B. Boyle, Keith Davidson, Tamara A. M. Chessa, Suhasini Kulkarni, Gavin E. Jarvis, Anca Sindrilaru, Karin Scharffetter-Kochanek, Oliver Rausch, Len R. Stephens, Phillip T. Hawkins
Journal: Blood (2008)
Management of uraemic pericarditis.
Authors: P Kramer, W Wigger, F Scheler
Journal: BMJ (1975)

Of 250 patients undergoing haemodialysis from 1967 to 1974 17 presented with uraemic pericarditis. Seven of these patients who had been transferred early enough to peritoneal dialysis treatment were cured without pericardiectomy (mean survival 18 months (range 6-36); no deaths). Only one patient was cured from his pericarditis by "aggressive haemodialysis." In seven out of 10 patients treated with haemodialysis, pericardiectomy finally had to be performed because of pericardial tamponade (postoperative survival 20 months (range 8-36); one death). Two patients died from pericardial tamponade before surgery. In patients with evidence of uraemic pericarditis frequent peritoneal dialysis with high fluid withdrawal is the treatment of choice, but in cardiac tamponade pericardiectomy should follow a preoperative pericardiocentesis with limited fluid aspiration. Of possible significance in the aetiology of pericarditis were the findings that 10 of the 17 patients had hypertension with cardiac enlargement and that 14 presented with evidence of underdialysis, possibly due to the reuse of dialysis components.