Hereditary Iron-Loading Anemia with Secondary Hemochromatosis
Authors: RICHARD B. BYRD
Journal: Annals of Internal Medicine (1961)

Article1 July 1961Hereditary Iron-Loading Anemia with Secondary HemochromatosisRICHARD B. BYRD, M.D., TALBERT COOPER, M.D., F.A.C.P.RICHARD B. BYRD, M.D.Search for more papers by this author, TALBERT COOPER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-103 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFive cases manifesting a distinctive form of refractory hypochromic anemia complicated consistently by the later development of hemochromatosis have been studied in an attempt to define further what appears to be a unique clinical entity, one that has been infrequently recognized previously.Uncomplicated primary, or idiopathic, hemochromatosis only rarely is associated with significant anemia (1). It appears instead to result from an increased intestinal absorptive capacity for dietary iron, this malfunction possibly being inherited and occurring in the absence of anemia or other hematologic abnormalities.Exogenous hemochromatosis has been described in a variety of patients with longstanding refractory anemias, most...References1. STAUFFERBUTTDOCKERTY MHHRMB: Hemochromatosis: clinical features and methods of diagnosis in 27 cases. Gastroenterology 27: 31, 1954. CrossrefMedlineGoogle Scholar2. BLOCKBETHARDJACOBSON MWL: Secondary hemochromatosis. Proc. Cent. Soc. Clin. Res. 25: 12, 1952. Google Scholar3. AUFDERHEIDEHORNSGOLDISH ACHLRJ: Secondary hemochromatosis. I. Transfusion (exogenous) hemochromatosis. Blood 8: 824, 1953. CrossrefMedlineGoogle Scholar4. DUBACHCALLENDERMOORE RSTCV: Studies in iron transportation and metabolism: absorption of radioactive iron in patients with fever and with anemias of varied etiology. Blood 3: 526, 1948. CrossrefMedlineGoogle Scholar5. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD B. BYRD, M.D.; TALBERT COOPER, M.D., F.A.C.P.Affiliations: Rochester, MinnesotaReceived for publication March 6, 1961.From the Section of Medicine, Mayo Clinic, Rochester, Minn.This is an abridgment of the thesis submitted by Dr. Byrd to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Medicine.Requests for reprints should be addressed to Talbert Cooper, M.D., F.A.C.P., Mayo Clinic, Rochester, Minn. 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