Hazard from Antibiotics in Myasthenia Gravis
Authors: MICHAEL P. MCQUILLEN
Journal: Annals of Internal Medicine (1970)

Editorial Notes1 September 1970Hazard from Antibiotics in Myasthenia GravisMICHAEL P. MCQUILLEN, M.D.MICHAEL P. MCQUILLEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-3-487 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThat blessings of antibiotics are mixed with hazards is shown again in a recent article (1) in the Annals of Clinical Research, the latest in a series of papers by Hokkanen and his colleagues on the enhancement of fatigue by certain antibiotics in patients with myasthenia gravis. Their electromyographic studies support the clinical observation that weakness produced by antibiotics in patients with myasthenia gravis is more profound when the myasthenia gravis is more serious and generalized.This antibiotic-induced weakness can occur in patients with no prior history of myasthenia gravis (2, 3) but usually in the presence of other factors,...References1. HOKKANENTOIVAKKA ED: Streptomycin-induced neuromuscular fatigue in myasthenia gravis. Ann Clin Res 1:220-226, 1969 MedlineGoogle Scholar2. MCQUILLENCANTORO'ROURKE MHJ: Myasthenic syndrome associated with antibiotics. Arch Neurol (Chicago) 18:402-415, 1968 CrossrefMedlineGoogle Scholar3. PITTINGERERYASAADAMSON CYR: Antibiotic-induced paralysis. Anesth Analg (Cleveland) 49:487-501, 1970 MedlineGoogle Scholar4. FREEMONPARKERGREER FRM: Unusual neurotoxicity of kanamycin. JAMA 200:410-411, 1967 CrossrefMedlineGoogle Scholar5. RYANSCHAINUCKHICKMAN KLR: Colistimethate toxicity. Report of a fatal case in a previously healthy child. JAMA 207:2099-2101, 1969 CrossrefMedlineGoogle Scholar6. ELMQVISTJOSEFFSON DJ: The nature of the neuromuscular block produced by neomycine. Acta Physiol Scand 54:105-110, 1962 CrossrefMedlineGoogle Scholar7. ELMQVISTLAMBERT DE: Detailed analysis of neuromuscular transmission in a patient with the myasthenic syndrome sometimes associated with bronchogenic carcinoma. Mayo Clin Proc 43:689-719, 1968 MedlineGoogle Scholar8. THESLEFF S: The physiology of neuromuscular transmission. Bull Schwer Acad Med Wiss 22:443-449, 1967 MedlineGoogle Scholar9. DAVIASIEMSENANDERSON JAR: Uremia, deafness, and paralysis due to irrigating antibiotic solutions. Arch Intern Med (Chicago) 125:135-139, 1970 CrossrefMedlineGoogle Scholar10. SWICKMAXWELLCHARACHE HEP: Peritoneal dialysis in Colistin intoxication: report of a case. J Pediat 74:976-980, 1970 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Kentucky Medical Center Lexington, Ky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacologically Active Compounds from Microbial OriginInfectious diseases: annual review of significant publications. 1 September 1970Volume 73, Issue 3Page: 487-488KeywordsAntibioticsElectromyographyFatigueMyasthenia gravis Issue Published: 1 September 1970 PDF downloadLoading ...