tbuckley/cabot-search huggingface dataset:
Endoscopic placement of a covered self-expandable metal stent in the minor papilla in patients with chronic pancreatitis and pancreas divisum
Authors: Z. Liao, Z. Li, W. Wang, Z. Ye, X. Lai, X. Wang, D. Zou
Journal: Endoscopy (2009)

Pancreas divisum is the most common anatomic variant of pancreatic development and may lead to chronic pancreatitis [1] [2]. Endoscopic stenting of the dorsal pancreatic duct is a safe and effective treatment for patients with chronic pancreatitis and pancreas divisum [3] [4]. Here we report three cases of chronic pancreatitis and pancreas divisum successfully treated with endoscopic placement of a self-expanding metal stent (SEMS) in the minor papilla.
Thoracic Duct Injury
Authors: Kamal G. Khalil
Journal: JAMA (1972)

Iatrogenic injury to the thoracic duct followed percutaneous cannulation of the left internal jugular vein. The case was managed successfully by supraclavicular ligation of the thoracic duct. We feel cannulation of the right internal jugular vein is preferable to cannulation of the left internal jugular vein.
Encourage Information Therapy
Authors: Katherine Lindner
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cost-effectiveness of Warfarin and Aspirin for Prophylaxis of Stroke in Patients With Nonvalvular Atrial Fibrillation
Authors: Brian F. Gage
Journal: JAMA (1995)

To examine the cost-effectiveness of prescribing warfarin sodium in patients who have nonvalvular atrial fibrillation (NVAF) with or without additional stroke risk factors (a prior stroke or transient ischemic attack, diabetes, hypertension, or heart disease).Decision and cost-effectiveness analyses. The probabilities for stroke, hemorrhage, and death were obtained from published randomized controlled trials. The quality-of-life estimates were obtained by interviewing 74 patients with atrial fibrillation. Costs were estimated from literature review, phone survey, and Medicare reimbursement.In the base case, the patients were 65 years of age and good candidates for warfarin therapy.Treatment with warfarin, aspirin, or no therapy in the decision analytic model.Quality-adjusted survival and marginal cost-effectiveness of warfarin as compared with aspirin or no therapy.For patients with NVAF and additional risk factors for stroke, warfarin therapy led to a greater quality-adjusted survival and to cost savings. For patients with NVAF and one additional risk factor, warfarin therapy cost $8000 per quality-adjusted life-year saved. For 65-year-old patients with NVAF alone, warfarin cost about $370,000 per quality-adjusted life-year saved, as compared with aspirin therapy. However, for 75-year-old patients with NVAF alone, prescribing warfarin cost $110,000 per quality-adjusted life-year saved. For patients who were not prescribed warfarin, aspirin was preferred to no therapy on the basis of both quality-adjusted survival and cost in all patients, regardless of the number of risk factors present.Treatment with warfarin is cost-effective in patients with NVAF and one or more additional risk factors for stroke. In 65-year-old patients with NVAF but no other risk factors for stroke, prescribing warfarin instead of aspirin would affect quality-adjusted survival minimally but increase costs significantly.
Genetic susceptibility to therapy-related leukemia after Hodgkin lymphoma or non-Hodgkin lymphoma: role of drug metabolism, apoptosis and DNA repair
Authors: Y Ding, C-L Sun, L Li, M Li, L Francisco, M Sabado, B Hahn, J Gyorffy, J Noe, G P Larson, S J Forman, R Bhatia, S Bhatia
Journal: Blood Cancer Journal (2012)

Genetic susceptibility to therapy-related leukemia after Hodgkin lymphoma or non-Hodgkin lymphoma: role of drug metabolism, apoptosis and DNA repair
Aspergillosis: A Disease Associated with Impaired Host Resistance.
Authors: S. Sabesin
Journal: Annals of Internal Medicine (1962)

s1 April 1962Aspergillosis: A Disease Associated with Impaired Host Resistance.S. Sabesin, M.D., P. Carbone, M.D., H. Sidransky, M.D.S. Sabesin, M.D.Search for more papers by this author, P. Carbone, M.D.Search for more papers by this author, H. Sidransky, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-689_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past six years, 19 patients at the National Institutes of Health have had histological evidence of disseminated, invasive, or localized aspergillosis. The seriousness of such infections has prompted a search for factors which predispose to the development of aspergillosis.This group consisted of 14 patients with leukemia, two with malignant lymphoma, one with adenocarcinoma of the colon, one with myeloid metaplasia, and one with hypersensitivity angiitis. All patients had associated bacterial infections and had received prolonged or repeated courses of antibiotics. Although most of the patients had leukopenia or had received corticosteroids, myelosuppressive agents, or both, no relationship... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCelebrating the ACP Centennial: From the Annals Archive Deborah Cotton Metrics Cited byCelebrating the ACP Centennial: From the Annals ArchiveDeborah Cotton, MD, MPH, Deputy EditorAspergillosis in a cancer hospitalVISCERAL MYCOTIC INFECTIONS 1 April 1962Volume 56, Issue 4Page: 689-690KeywordsAdenocarcinomaAntibioticsAspergillosisColonHypersensitivityLymphocytic leukemiaLymphomaVasculitis Issue Published: 1 April 1962 PDF downloadLoading ...
Angiosarcoma of the liver: a signal lesion of vinyl chloride exposure.
Authors: N J Vianna, J Brady, P Harper
Journal: Environmental Health Perspectives (1981)

Vinyl chloride (VCM) induced angiosarcoma of the liver (ASL) is a rare vascular tumor which might be associated with a wide range of disease states. The possibility that this tumor might be a signal lesion is supported by mortality studies suggesting that cancers of the digestive, respiratory, neurological and lymphatic systems have occurred more often than expected in VCM workers. There is also evidence that certain non-neoplastic disorders, such as pneumoconiosis and excess fetal deaths, may be associated with this chemical. It has been suggested that a gradual increase in the incidence of ASL might have occurred in recent years. This could be a reflection of the long latency period and/or the increased recognition of this entity. Several cases of ASL have occurred in people living in the vicinity of VCM plants. This raises the possibility that low-level exposure to this chemical over a long period might induce ASL.
Adequacy of general practitioners' premises for minor surgery
Authors: P N Hoffman, L J Taylor, B D Cookson, D Morgan
Journal: BMJ (1991)

there is such a level of apathy and indifference among BMA members?As one who wishes to see a more vigorous, responsive, and successful BMA I suggest that greater use be made of the secret ballot at divisional meetings, and that rules be changed so that secret ballots can be held at the request of any member present.Any form of secret ballot, correctly used, could encourage a greater sense of participation and thus help to ensure the future success of our BMA.
Contractility and Extractability of Heart Actomyosin After Death
Authors: L. DETTLI, R. J. BING
Journal: Circulation Research (1956)

The contractility and extractability of actomyosin and proteins prepared from dogs' heart immediately, and one hour after death were compared. The yield of total and soluble proteins and of actomyosin was found to be identical. In addition, there was no difference between the after-loaded contractions of actomyosin bands of fresh preparation and those obtained one hour after death.
Meningioma Detected Incidentally on Early Tc-99m MDP Whole-Body Imaging During a Workup for Breast Cancer
Authors: Tsui-Fen Cheng, Yen-Kung Chen, Chia-Hung Kao
Journal: Clinical Nuclear Medicine (2004)

A 47-year-old woman was diagnosed with infiltrating ductal carcinoma of the right breast postoperatively. Results of an early whole-body Tc-99m MDP scan revealed a hypervascular lesion in the right frontal region. Delayed whole-body images were normal. An axial cranial computed tomography scan showed a relatively hyperdense tumor in the right frontal region. These findings were consistent with a benign meningioma. The patient subsequently underwent a craniotomy. Histopathologic interpretation showed meningioma with proliferation of meningothelial cells arranged in a whorl-like or fascicular pattern.
Development of the rat heart conduction system in malformed hearts induced by hyperthermia: Origin of the atrial conduction system differs from that of ventricular one
Authors: N. Aoyama, S. Yamashina, O. Katsumata, K. Kohno, J. Nakahata, T. Izumi, K. Soma, T. Ohwada
Journal: European Journal of Heart Failure (2000)
Presidential Address*
Authors: FRANK SMITHIES
Journal: Annals of Internal Medicine (1928)

Article1 May 1928Presidential Address(American College of Physicians)FRANK SMITHIES, M.D., Sc.D.FRANK SMITHIES, M.D., Sc.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-11-861 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past, the parting words of your retiring president have dealt largely with the national and international necessity for such an organization as The American College of Physicians. This vindication of our society does not require reiteration; very little if anything, can be said supplementary to the masterly addresses delivered by former Presidents James M. Anders, Harlow Brooks and Alfred Stengel. In no uncertain way, have these gentlemen defined the fields of endeavor open to The College and most potently have they emphasized for us and the curious, if not critical, the pressing urge for just such grouping of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Delivered before the American College of Physicians, March, 1928, New Orleans, La. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1928Volume 1, Issue 11Page: 861-874 ePublished: 1 December 2008 Issue Published: 1 May 1928 PDF downloadLoading ...
Case-control study of prostatic cancer in employees of the United Kingdom Atomic Energy Authority.
Authors: C Rooney, V Beral, N Maconochie, P Fraser, G Davies
Journal: BMJ (1993)

OBJECTIVE--To investigate the relation between risk of prostatic cancer and occupational exposures, especially to radionuclides, in employees of the United Kingdom Atomic Energy Authority. DESIGN--Case-control study of men with prostatic cancer and matched controls. Information about sociodemographic factors and exposures to radionuclides and other substances was abstracted and classified for each subject from United Kingdom Atomic Energy Authority records without knowledge of who had cancer. SUBJECTS--136 men with prostatic cancer diagnosed between 1946 and 1986 and 404 matched controls, all employees of United Kingdom Atomic Energy Authority. MAIN OUTCOME MEASURES--Documented or possible contamination with specific radionuclides. RESULTS--Risk of prostatic cancer was significantly increased in men who were internally contaminated with or who worked in environments potentially contaminated by tritium, chromium-51, iron-59, cobalt-60, or zinc-65. Internal contamination with at least one of the five radionuclides was detected in 14 men with prostatic cancer (10%) and 12 controls (3%) (relative risk 5.32 (95% confidence interval 1.87 to 17.24). Altogether 28 men with prostatic cancer (21%) and 46 controls (11%) worked in environments potentially contaminated by at least one of the five radionuclides (relative risk 2.36 (1.26 to 4.43)); about two thirds worked at heavy water reactors (19 men with prostatic cancer and 32 controls (relative risk 2.13 (1.00 to 4.52)). Relative risk of prostatic cancer increased with increasing duration of work in places potentially contaminated by these radionuclides and with increasing level of probable contamination. Prostatic cancer was not associated with exposure to plutonium, uranium, cadmium, boron, beryllium, or organic or inorganic chemicals. CONCLUSIONS--Risk of prostatic cancer risk was increased in United Kingdom Atomic Energy Authority workers who were occupationally exposed to tritium, 51Cr, 59Fe, 60Co, or 65Zn. Exposure to these radionuclides was infrequent, and their separate effects could not be evaluated.
The Balanced Curriculum
Authors: Henry Cohen
Journal: New England Journal of Medicine (1953)

NO ONE will dispute the importance of the topic assigned to me in this symposium, nor can it be doubted that the core of the problem of medical education lies in the balanced curriculum. This is a balance between the pursuit of knowledge for its own sake, for its intrinsic interest and its educational value, on the one hand, and on the other, its pursuit for vocational and technical needs, though the boundaries between are blurred, and most vocational needs can be presented in a liberal context. It is also a balance between the humanities and science since both are . . .
P17.06 * GLIOSARCOMA PRESENTING WITH PARIETAL SIGNS IN A 67 YEAR-OLD FILIPINO MALE: A CASE REPORT
Authors: J. P. Bautista, M. Martinez, R. Torcuator
Journal: Neuro-Oncology (2014)

BACKGROUND: Gliosarcoma is a well-circumscribed tumor of the central nervous system with clearly identifiable biphasic glial and metaplastic mesenchymal components (1). The incidence of gliosarcoma is between 1.8% and 2.8% of all malignant gliomas and thus represents an exceptionally rare neoplasm (3). The typical presentation of patients with gliosarcoma would be consistent with a rapidly growing intracranial tumor showing signs of increased intracranial pressure such as headache and vomiting, other signs include cognitive decline, hemiparesis and seizures. Literature about this disease entity has been limited to a few case reports and series due to its rarity. Pathogenesis remains unclear, and optimal treatment of gliosarcoma remains to be defined (3). We report a case of a 67 year-old male with a CNS tumor uniquely presenting only with parietal lobe signs, underwent craniotomy and tumor resection, with histopathology revealing a gliosarcoma. CASE: A 67 year-old male, a mechanical engineer, initially presented at a different institution due to a month's history of difficulty in reading, writing, and calculating. A cranial MRI was done with findings of a subacute infarct over the left occipital and part of the lateral temporal lobe. Patient was initially treated as a case of stroke, but noted progression of earlier described symptoms. Patient now sought consult at our institution where an MR spectroscopy and perfusion was done showing a lobulated lesion in the left occipito-temporal lobe with moderate perilesional edema extending into the left temporal and parietal lobes. Results of spectroscopy and perfusion studies were suggestive of a neoplastic process. Histopathology and staining tests confirmed the diagnosis of a gliosarcoma. CONCLUSION: Primary gliosarcoma is a rare CNS tumor currently classified as a Grade IV neoplasm and a variant of glioblastoma multiforme (GBM). Epidemiology and natural history have been described as similar to that of GBM, however gliosarcoma has been found to have greater temporal lobe involvement and propensity to metastasize extracranially (3). The objective of this case report is to describe the onset, course and management of a rare case of gliosarcoma initially manifesting only with parietal signs.
Hydatid Disease of the Liver
Authors: Kim Eagle, Sanjiv Chopra
Journal: New England Journal of Medicine (1993)

Figure 1. Hydatid Disease of the Liver. A computed tomographic scan of the liver of a 57-year-old woman reveals large cystic, lobulated structures with daughter cysts, consistent with hydatid disease. The patient had severe abdominal pain and a markedly enlarged, firm, and nodular liver. Her white-cell count was 12,000 per cubic millimeter, with 45 percent eosinophils. A serologic test for echinococcal disease was positive.
Low incidence of osteoarthrosis of the hips in contrast with osteoarthrosis of the knees among rural Saudis: why?
Authors: W C Agunwa
Journal: Annals of the Rheumatic Diseases (1989)

Laterality and incidence of adhesive capsulitis of the shoulder and plantar fasciitis among rural Saudis in the Jeddah zone SIR, In western medical publications adhesive capsulitis ('frozen shoulder', 'shoulder-hand syndrome') is suppos- edly commoner on the left side,' perhaps related to the finding that in an appreciable number of cases of adhesive capsulitis there is a preceding episode of a silent or overt cardiac infarct.The laterality and incidence of this condition and of plantar fasciitis were investigated among rural Saudis in a newly opened government general hospital in the Jeddah zone to see if the findings correlated with those in the West.A significant right sided preponderance in clinical symptoms of adhesive capsulitis2 3 and a significant left sided preponderance of plantar fasciitis was found among 6000 rural Saudis in the Jeddah zone, seen in the orthopaedic outpatients clinic in the first 18 months of the newly opened hospital.There were 375 presentations of clinical adhesive capsulitis from 369 patients (201 male, 168 female) with the complaint, an incidence of 6-15% (369/6000).The age range was 17-75 years, with an average age for the men of 43 and for the women of 42.The disorder was bilateral in six patients (three men, three women), right sided in 216, and left sided in 147-a significant right sided preponderance.Over the same period there were 84 presentations of clinical plantar fasciitis from 78 patients (63 male, 15 female), an incidence of 1-3%.4Symptoms were left sided in 48 instances, right sided in 18, and bilateral in 12-a significant left sided preponderance.The age range was 28-60 years, with an average age for the men of 35 and for the women of 43.For those with bilateral involvement the average age was also 43 years.No ready explanation was found for the laterality observed in these conditions.Perhaps social customs are implicated.Further studies seem to be warranted.
Plasma thyrotropin-releasing hormone concentrations in the rat. Effect of thyroid excess and deficiency and cold exposure.
Authors: C H Emerson, R D Utiger
Journal: Journal of Clinical Investigation (1975)

To investigate the physiology of thyrotropin-releasing hormone (TRH) secretion from hypothalamus and brain, a method for measurement of peripheral plasma TRH concentrations in rats was developed. Blood was collected in heparin and dimercaptopropanol containing [3H]TRH to determine recovery. The plasma was extracted with methanol and the redissolved dried methanol extracts applied to anti-TRH Sepharose columns. These columns bound greater than 80% of 125I-TRH applied and had a capacity in excess of 20 ng TRH. TRH was eluted from the anti-TRH Sepharose with acetic acid and quantitated by radioimmunoassay of the lyophilized acetic acid eluate. Mean recovery of unlabeled TRH was 44.7+/-6.1% (SD) and mean recovery of [3H]TRH was 44.0+/-4.0%. Mean plasma TRH concentrations, corrected for recovery, in plasma pools from eight groups of normal male rats (four to seven pools/experiment, five to seven rats/pool) ranged from 7 to 30 pg/ml (mean, 16). In experiments in which rats were given 5, 10, 15, 0r 50 mug thyroxine daily for 1 wk or in thyroidectomized rats, mean plasma TRH concentrations did not differ significantly from those of control animals sacrificed at the same time. In each experiment, four to seven plasma pools, each from five to seven rats, were processed from both control and experimental groups. No changes in plasma TRH concentrations were found in rats exposed to cold (4degreeC) for 30, 60, and 90-180 min. Signigicant increases in plasma thyrotropin (TSH) concentrations were found in all cold-exposed animals. These results provide no evidence that thyroid hormone excess of deficiency affects TRH secretion. If TRH secretion is responsible for cold-induced increases in plasma TSH concentrations, the increase in TRH secretion is of insufficient magnitude to alter periperal plasma TRH concentrations.
Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression
Authors: Jun Yang, Oliver Staples, Luke W. Thomas, Thomas Briston, Mathew Robson, Evon Poon, Maria L. Simões, Ethaar El-Emir, Francesca M. Buffa, Afshan Ahmed, Nicholas P. Annear, Deepa Shukla, Barbara R. Pedley, Patrick H. Maxwell, Adrian L. Harris, Margaret Ashcroft
Journal: Journal of Clinical Investigation (2012)

Increased expression of the regulatory subunit of HIFs (HIF-1α or HIF-2α) is associated with metabolic adaptation, angiogenesis, and tumor progression. Understanding how HIFs are regulated is of intense interest. Intriguingly, the molecular mechanisms that link mitochondrial function with the HIF-regulated response to hypoxia remain to be unraveled. Here we describe what we believe to be novel functions of the human gene CHCHD4 in this context. We found that CHCHD4 encodes 2 alternatively spliced, differentially expressed isoforms (CHCHD4.1 and CHCHD4.2). CHCHD4.1 is identical to MIA40, the homolog of yeast Mia40, a key component of the mitochondrial disulfide relay system that regulates electron transfer to cytochrome c. Further analysis revealed that CHCHD4 proteins contain an evolutionarily conserved coiled-coil-helix-coiled-coil-helix (CHCH) domain important for mitochondrial localization. Modulation of CHCHD4 protein expression in tumor cells regulated cellular oxygen consumption rate and metabolism. Targeting CHCHD4 expression blocked HIF-1α induction and function in hypoxia and resulted in inhibition of tumor growth and angiogenesis in vivo. Overexpression of CHCHD4 proteins in tumor cells enhanced HIF-1α protein stabilization in hypoxic conditions, an effect insensitive to antioxidant treatment. In human cancers, increased CHCHD4 expression was found to correlate with the hypoxia gene expression signature, increasing tumor grade, and reduced patient survival. Thus, our study identifies a mitochondrial mechanism that is critical for regulating the hypoxic response in tumors.
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
Authors: Josette-Renée Landry, Sarah Kinston, Kathy Knezevic, Marella F.T.R. de Bruijn, Nicola Wilson, Wade T. Nottingham, Michael Peitz, Frank Edenhofer, John E. Pimanda, Katrin Ottersbach, Berthold Göttgens
Journal: Blood (2008)