tbuckley/cabot-search huggingface dataset:
Amoebiasis--Pulmonary Complications
Authors: B. A. Dormer, J. Friedlander
Journal: BMJ (1941)

MEDICAL JOURNALrenders the infection eventually more difficult to eradicate.The following principles may be enunciated:1.A fresh infection is more easy to eradicate than one of long standing.2. The widely accepted practice of periodic injections of emetine, or even inadequate doses by the mouth of other emetine compounds, is not recommended, for it has been indicated that, so far from effecting a cure, this method tends to render E. histolytica emetine-fast.3. Cases, however resistant, can eventually be cured, provided the course of anti-amoebic treatment is sufficiently thorough and prolonged.4. Quinoxyl is a potent non-toxic drug, causing few disagree- able sequelae.In resistant cases of amoebiasis it produces the most permanent results in combination with emetine bismuth iodide.This treatment is usually well tolerated, provided that minutiae of dosage and timing are observed. Results of TreatmentTABLE I.-Showing Nature of Anti-amoebic Treatmtient on 276 (51.5% of the Series) previously Untreated Cases (110 with Active Amoebae atnd 166 with Cysts) Emetine bismuth iodide courses of 20 to 26 grains .. .. 29 Emetine periodide courses of 28 to 72 grains with tablets of fel bovinum.9 Quinoxyl pills (4 grains), plus quinoxyl retention enemata 21°% 18 Stovarsol 80 grains (cyst-carrier case) I Combined treatments: Emetine bismuth iodide 20 to 26 grains, plus quinoxyl reten- tion enemata 2% (1 case, 5%) .198Emetine periodide 20 to 30 grains, plus quinoxyl retention enemata 2J% 17 Auremetine 30 grains, plus quinoxyl retention enemata 2J% 4Out of 276 cases there were only 4 (1.4%) uncured.Two definite relapses occurred one year later, and these were ultimately cured with further treatment.In 2 cases the result could not-be followed up.TABLE II.-ShowingEffect of Emetine Injection Treatment on 259 (48.5% of the Series) Cases (138 with Active Amoebae anid 121 with Cysts) prior to Parasitic and Clinzical Relapse Emetine injections ranging from 40 to 60 grains, given over a period of 4 to 6 months, in 2 cases reinforced by intravenous emetine 171Emetine injections, plus 2 to 3 courses of emetine bismuth iodide, emetine periodide, or auremetine .67Emetine injections, plus oral quinoxyl, stovarsol, carbarsone, or ipecacuanha.21 was curative a year later.
Epidermal Growth Factor Receptor Mutations: Effect on Volume Doubling Time of Non–Small-Cell Lung Cancer Patients
Authors: Ryota Nakamura, Yoshihisa Inage, Rika Tobita, Kazuko Mori, Takeshi Numata, Hidetoshi Yanai, Takeo Endo, Haruo Ohtani, Hiroaki Satoh, Kenji Yuzawa, Masanori Koizumi, Hamaichi Ueki
Journal: Journal of Thoracic Oncology (2014)
A Longitudinal Study of Some Physiological Parameters and Autogenic Training
Authors: A.K. Tebecis, Y. Ohno, H. Matsubara, H. Sugano, T. Takeya, Y. Ikemi, M. Takasaki
Journal: Psychotherapy and Psychosomatics (1976)

Physiological parameters were studied over 4.5 months in normal high-school girls. One group frequently practised autogenic training (AT) whereas the other (control) did not. After 4.5 months the physiology of the AT, but not the control group had changed to some extent. The mean increase in finger skin temperature in the final session was significantly greater in the AT group than in the control group, especially in subjects who experienced hand warmth during AT. No significant differenced between groups were apparent for finger blood flow, but within the AT group the girls who experienced hand warmth showed a significantly greater blood flow than those who did not experience hand warmth. The electroencephalogram (EEG) of the AT group showed significantly more 'slow' (delta and theta) and less fast (alpha and beta) activity than at the beginning of the project. Microvibration (MV) of the thumb did not differ significantly in any comparisons. Both in the AT and control group means there were no significant differences between the periods before, during and after AT although significant changes did occur in some individuals of the AT group in the final session. In particular, in 3 of 14 AT subjects respiration rate decreases markedly even though weekly training had not included any breathing exercies. The results suggest that the effects of AT are predominantly long-term, resulting in gradual physiological changes that are maintained to some extent between practice periods.
How Health Information Technology Is Failing to Achieve Its Full Potential
Authors: Aaron E. Carroll
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Insect and scorpion bites and stings
Authors: F. E. Russell
Journal: JAMA (1973)

To the Editor.—  The comments of Drs. Logan, Epstein, Settipane, and Boyd in their letters toThe Journal(222:1309, 1972), regarding Mr. Horen's article on Insect and Scorpion Sting (221:894, 1972) are well taken and we agree with their timely concerns. We would like to comment on several other misunderstandings in Mr. Horen's article that cause physicians and toxicologists some anxiety and may lead to inadequate or unwise clinical decisions.  I am sure that Mr. Horen did not mean that the arthropods he notes of the orders Hymenoptera and Scorpionida bite. All envenomations by scorpions are by their stings, as are the other poisonings noted by the author. Although this may seem academic, we believe it is important to separate those venomous animals that bite from those that sting. In the former group, the animal uses its venom chiefly as an offensive weapon, while in the latter, it is designed
Threshold levels of 25-hydroxyvitamin D and parathyroid hormone for impaired bone health in children with congenital ichthyosis and type IV and V skin
Authors: G. Sethuraman, V. Sreenivas, V.K. Yenamandra, N. Gupta, V.K. Sharma, R.K. Marwaha, N. Bhari, M. Irshad, M. Kabra, S. Thulkar
Journal: British Journal of Dermatology (2014)

Patients with congenital ichthyosis, especially those with darker skin types, are at increased risk of developing vitamin D deficiency and rickets. The relationships between 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and bone health have not been studied previously, in ichthyosis.To determine the threshold levels of 25(OH)D and PTH for impaired bone health in children with congenital ichthyosis.In this cross-sectional study, 119 children with ichthyosis and 168 controls were recruited. Serum 25(OH)D, PTH, calcium, phosphate and alkaline phosphatase (ALP) were measured. Radiological screening for rickets was carried out only in children with ichthyosis.Forty-seven children with ichthyosis had either clinical or radiological evidence of rickets. The correlation between serum 25(OH)D and PTH showed that a serum level of 25(OH)D 8 ng mL(-1) was associated with a significant increase in PTH. The correlation between PTH and ALP showed that a serum PTH level of 75 pg mL(-1) was associated with a significant increase in ALP levels. Of the different clinical phenotypes of ichthyosis, both autosomal recessive congenital ichthyosis (ARCI) and epidermolytic ichthyosis (EI) were found to have significantly increased PTH, ALP and radiological rickets scores compared with common ichthyosis.Serum levels of 25(OH)D ≤ 8 ng mL(-1) and PTH ≥ 75 pg mL(-1) significantly increases the risk for development of rickets [odds ratio (OR) 2·8; 95% confidence interval (CI) 1·05-7·40; P = 0·04] in ichthyosis. Among the different types, patients with ARCI (OR 4·83; 95% CI 1·74-13·45; P < 0·01) and EI (OR 5·71; 95% CI 1·74-18·79; P < 0·01) are at an increased risk of developing rickets.
Increased incidence of urinary tract infection in patients with rheumatoid arthritis and secondary Sjogren's syndrome.
Authors: M Tishler, D Caspi, Y Almog, R Segal, M Yaron
Journal: Annals of the Rheumatic Diseases (1992)

The incidence of lower urinary tract infection in 120 women with rheumatoid arthritis and secondary Sjögren's syndrome was evaluated retrospectively. Thirty one patients (26%) had secondary Sjögren's syndrome. Recurrent urinary tract infection was significantly more common in these patients (11/31) than in patients without Sjögren's syndrome (4/89). Habitual leucocyturia was also more common in patients with secondary Sjögren's syndrome (18/31) than in patients with rheumatoid arthritis without Sjögren's syndrome (8/89). Of seven patients with vaginal sicca symptoms, six had recurrent urinary tract infection. Urinary 24 hour mucopolysaccharide excretion in 20 patients with Sjögren's syndrome was similar to the excretion in 10 patients without Sjögren's syndrome. These results show that recurrent urinary tract infection is significantly more common in women with rheumatoid arthritis and secondary Sjögren's syndrome. A local deficit in protective urinary mucosal secretion or other immune mechanisms may be responsible for this susceptibility.
DDB1-CUL4 and MLL1 Mediate Oncogene-Induced p16<i>INK4a</i> Activation
Authors: Yojiro Kotake, Yaxue Zeng, Yue Xiong
Journal: Cancer Research (2009)

The induction of cellular senescence by oncogenic signals acts as a barrier to cellular transformation and is attained, in part, by the elevation of the p16(INK4a) tumor suppressor gene. p16 expression is repressed epigenetically by Polycomb, but how p16 is induced is not known. We report here that the p16 locus is H3K4-methylated in highly expressing cells. H3K4 methyltransferase MLL1 directly binds to and is required, along with its core component RbBP5, for the induction of p16 by oncogenic Ras. We further show that damaged DNA binding protein DDB1 and CUL4, which assemble distinct E3 ubiquitin ligases by recruiting various WD40 proteins, act upstream of MLL1-mediated H3K4 methylation. We showed that CUL4A directly binds to p16 and that silencing DDB1 blocks Ras-induced p16 activation. Ras expression dissociates BMI1 from the p16 locus, whereas both CUL4 and MLL1 bind to the p16 locus similarly in both normal and oncogenic stimulated cells. These results suggest that DDB1-CUL4 and MLL1 complexes constitute a novel pathway that mediates p16 activation during oncogenic checkpoint response and is repressed by the polycomb repression complexes during normal growth of young cells.
Occurrence of Colorectal Adenomas in Younger Adults: An Epidemiologic Necropsy Study
Authors: Cheryl J. Pendergrass, Daniel L. Edelstein, Linda M. Hylind, Blaine T. Phillips, Christine Iacobuzio–Donahue, Katharine Romans, Constance A. Griffin, Marcia Cruz–Correa, Anne C. Tersmette, G. Johan A. Offerhaus, Francis M. Giardiello
Journal: Clinical Gastroenterology and Hepatology (2008)
Errors in clinical reasoning: causes and remedial strategies
Authors: I. A Scott
Journal: BMJ (2009)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Errors in clinical reasoning: causes and remedial strategies Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
THE SIGNIFICANCE OF ANAPHYLAXIS IN PNEUMOCOCCUS IMMUNITY
Authors: George M. Mackenzie
Journal: The Journal of Experimental Medicine (1925)

1. Intraperitoneal injections of killed and living broth cultures of a virulent pneumococcus produce in guinea pigs a high degree of active immunity and a serum with strong protective power. 2. Despite the protective power of such serum no agglutinins for the homologous organism and no precipitins for soluble derivatives were demonstrable. 3. Guinea pig immunity to pneumococcus infection produced by the method described is not attended by cutaneous allergy to derivatives of the pneumococcus used for immunization. 4. During the course of an artificially produced active immunity, anaphylaxis may at times be present and at times absent without any measurable effect upon the resistance of the animal to infection by intraperitoneal injection. 5. In the particular instance studied, the experiments indicate that anaphylaxis to pneumococcus protein has no important effect upon the resistance of the animal to infection. It appears to be a concomitant without any significant rôle in the immunity mechanism.
Getting Evidence into Practice: Tackling inequality by implementing high quality research
Authors: K. Pettersen
Journal: BMJ (2011)

A vast amount of medical research is published every day: an average of 11 systematic reviews and 75 controlled trials ( PLoS Med 2010;7:e1000326). Information overload is often cited as the main reason why much of this research never affects clinical practice and so fails to lead to the promised improvements in healthcare. So what can be done to change this?

The Getting Evidence into Practice award recognises the efforts of clinicians committed to successful implementation of high quality research. Our expectations of entries were high: we looked for initiatives that not only implemented high quality research (from guidelines or protocols based on systematic reviews or from individual systematic reviews) but also used evidence based implementation protocols and demonstrated improvements in outcomes that matter to patients.

Our entries this year included initiatives as diverse as a programme conducted in Manchester to increase rates of diagnosis of chronic kidney failure; a multicentre initiative spanning America, Canada, Europe, and Asia to implement the World Health Organization Safer Surgical Checklist; and a Hong Kong initiative aimed at localising …
Global offensive against AIDS spurs research and raises hopes
Authors: C. Marwick
Journal: JAMA (1987)

"RESTRAINED but real optimism" emerged as the dominant mood of the Third International Conference on AIDS held last month in Washington, DC. Reflecting on a week in which some 7350 participants in scientific sessions and nearly 900 news media representatives gathered to share their findings, increase their understanding, and regird their loins for the continuing battle against human immunodeficiency virus (HIV), June Osborn, MD, contrasted this conference with the two previous ones where, she said, first shock and then gloom prevailed. Osborn, dean of the School of Public Health, University of Michigan, Ann Arbor, credited several factors for the change. Foremost is the sense of global involvement that has replaced the isolation felt as, one by one for six years now, 113 countries recognized the virus among them. The careful projections of disease spread made in response, and the research directions charted for coping with what has been called an
Inflammation in common variable immunodeficiency is associated with a distinct CD8+ response to cytomegalovirus
Authors: Sayed Mahdi Marashi, Mohammad Raeiszadeh, Sarita Workman, Afsar Rahbar, Cecilia Soderberg-Naucler, Paul Klenerman, Ronnie Chee, A. David Webster, Richard S.B. Milne, Vincent C. Emery
Journal: Journal of Allergy and Clinical Immunology (2011)
TCT-823 Results from LateTIME: A Randomized, Placebo Controlled Trial of Intracoronary Stem Cell Delivery Two to Three Weeks Following Acute Myocardial Infarction from the Cardiovascular Cell Therapy Research Network
Authors: Timothy D. Henry, Jay H. Traverse, Carl J. Pepine, James T. Willerson, Stephen Ellis, David X. Zhao, Lara Simpson, Emerson Perin, Marc Penn, Kenneth W. Baran, Jeffrey Chambers, Charles Lambert, Ganesh Raveendran, Daniel Simon, Adrian P. Gee, John R. Forder, Doris A. Taylor, Christopher R. Cogle, Rachel E. Olson, Deirdre Smith, Carrie Geither, Sonia I. Skarlatos, Lemuel A. Moye, Robert D. Simari
Journal: Journal of the American College of Cardiology (2013)
Abstract LB-176: Discovery of CWP232291: A novel and potent small molecule inhibitor of Wnt signaling in hematological malignacies
Authors: Joo Young Cha, Ji-Eun Jung, Kathy Emami, Isabelle Briaud, Fnu Tenzin, Younghee Pyon, Donghee Lee, Jae Uk Chung, Jong Heun Lee, Se-Woong Oh, Kyung Yun Jung, Jin Keon Pai
Journal: Cancer Research (2010)

Abstract Discussion Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-176.
Management of hypertension in pregnancy
Authors: L A Magee, M P Ornstein, P von Dadelszen
Journal: BMJ (1999)

Hypertension in pregnancy is not a single entity 1 but comprises:x Chronic hypertension, which complicates 1%-5% of pregnancies and is defined as a blood pressure greater than 140/90 mm Hg that either predates pregnancy or develops before 20 weeks of gestation x Pregnancy induced hypertension, which develops after 20 weeks of gestation and complicates 5%-10% of pregnancies x Gestational hypertension, which is pregnancy induced hypertension in isolation; it may reflect a familial predisposition to chronic hypertension, or it may be an early manifestation of pre-eclampsia x Pre-eclampsia, which is pregnancy induced hypertension in association with proteinuria or oedema, or both, and virtually any organ system may be affected.The types of hypertension in pregnancy differ primarily in the incidence, and not the nature, of maternal and perinatal complications.The UK confidential inquiries into maternal deaths has consistently shown an excess maternal mortality associated with hypertension in pregnancy due to intracerebral haemorrhage, eclampsia, or end organ dysfunction.Perinatal mortality and morbidity reflect both the fetal syndrome of pre-eclampsia (intrauterine growth restriction) and the consequences of iatrogenic prematurity resulting from deteriorating maternal disease or fetal condition.Treatment aims to improve both maternal and perinatal outcomes.In this article we review randomised controlled trials of drug and non-drug treatments for hypertension in pregnancy. MethodsWe searched Medline (1966-97), Hypertension in Pregnancy (to 1997), bibliographies, and texts for articles in English or French that met several criteria (box).Data were abstracted independently by two reviewers who corroborated their findings.The most recent data were abstracted from duplicate publications.Quantitative analysis was performed with the Cochrane Review Manager software (version 3.0.1)that uses the Peto odds ratio (95% confidence interval) as the summary statistic.Where it occurs, we describe differences in outcomes between trials that were greater than could be expected by chance alone.We qualitatively analysed the study design, participants, interventions, and outcome definitions.
MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS AND NEOINTIMA FORMATION AFTER IMPLANTATION OF EPC-CAPTURE STENTS IN NSTE-ACS (JACK-EPC RANDOMIZED TRIAL)
Authors: Wojciech Wojakowski, Andrzej Pyrlik, Marek Krol, Maciej Kazmierski, Andrzej Ochala, Pawel Buszman, Damian Kawecki, Andrzej Rudnik, Grzegorz Smolka, Krzysztof Milewski, Aleksander Zurakowski, Wieslaw Cybulski, Marek Kondys, Iwona Mroz, Michal Tendera
Journal: Journal of the American College of Cardiology (2010)
Regulatory Role of T Cells Producing both Interferon γ and Interleukin 10 in Persistent Infection
Authors: Giorgio Trinchieri
Journal: The Journal of Experimental Medicine (2001)

IL-10 was originally described as a cytokine produced by Th2 cells and mediating antiinflammatory effects, by acting primarily on phagocytic cells and on antigen-presenting cells ([1][1]). IL-10 inhibits, in these cells, transcription and production of proinflammatory cytokines, such as TNF and IL-
The effectiveness of antiarrhythmic agents on early-cycle premature ventricular complexes.
Authors: R J Krone, J P Miller, R E Kleiger, K W Clark, G C Oliver
Journal: Circulation (1981)

Twelve patients completed a double-blind, crossover antiarrhythmic drug trial in which 300 mg of quinidine, 500 mg of procainamide, 100 mg of phenytoin, or placebo was given four times daily on subsequent weeks. Analysis of 24-hour Holter tapes with a computerized analysis system (Argus/H) permitted accurate counting of premature ventricular complexes (PVCs) subclassified according to coupling interval. No antiarrhythmic agent demonstrated a significant overall reduction in the number of PVCs, but both quinidine and procainamide showed a statistically significant (p less than 0.05) reduction of PVCs with coupling intervals less than 400 msec. This effect was noted both in isolated PVCs (quinidine only) and in PVCs that were part of a couplet or run (both drugs). These findings demonstrate that clinically important effects of procainamide and quinidine can occur in the absence of an overall reduction in the number of PVCs.
Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice
Authors: Tanya N. Mayadas, Donna Lee Mendrick, Hugh R. Brady, Tao Tang, Aikaterina Papayianni, Karel J.M. Assmann, Denisa D. Wagner, Richard O. Hynes, Ramzi S. Cotran
Journal: Kidney International (1996)
Hazards and Benefits of Alcohol
Authors: John D. Potter
Journal: New England Journal of Medicine (1997)

Alcohol occupies a unique place in many human societies; it is a widely used drug, tolerated physiologically and socially, with a place in religious ceremony, in ritual, in spontaneous celebration, and in everyday social transactions, but also a drug that contributes extensively to illness, to violence, to social disorder, and to mortality. Humans have consumed alcohol on a regular basis over the past 10,000 to 15,000 years. Like fat and sugar, alcohol is rare in nature, and as with fat and sugar, we have few biologic curbs on excess consumption. The joys of abstinence, moderation, and drunkenness have produced a . . .