tbuckley/cabot-search huggingface dataset:
Graft dysfunction mimicking autoimmune hepatitis following liver transplantation in adults
Authors: Michael A. Heneghan, Bernard C. Portmann, Suzanne M. Norris, Roger Williams, Paolo Muiesan, Mohamed Rela, Nigel D. Heaton, John G. O'Grady
Journal: Hepatology (2001)

In children, a type of graft dysfunction associated with autoimmune features has been described. We have identified 7 adult liver-transplant (LT) recipients from a series of over 1,000 consecutive transplant recipients who presented between 0.3 years and 7.2 years following transplantation with characteristic symptoms, autoantibody profiles, and histologic findings of autoimmune disease. The indications for transplantation were Ecstasy overdose, alcohol-related cirrhosis, primary sclerosing cholangitis (PSC) (2), primary biliary cirrhosis (PBC), hepatitis C cirrhosis, and cryptogenic cirrhosis. Two patterns of de novo autoantibody development were noted; anti-liver-kidney-microsome (LKM) antibody development at high titer in association with an aspartate transaminase (AST) &gt; 500 and antinuclear (ANA) and antismooth muscle (AMA) antibody development at titers &gt;1/80 with lower AST levels. All cases had elevated IgG. Liver biopsies showed changes of an autoimmune-type hepatitis with portal and periportal hepatitis in association with a marked infiltrate of plasma cells, lymphocytes, and bridging collapse. Two patients lost their grafts because of the disease. Patients were treated with reintroduction of steroids and azathioprine in cases in which it had been withdrawn. Major histocompatibility class I and II mismatching did not incur risk. Eight of 12 liver allografts were acquired from either DRB*0301- or DRB*0401-positive donors, and 4 recipients were DRB*0301-positive. This series illustrates that both symptoms and histologic findings of graft dysfunction compatible with autoimmune hepatitis (AIH) exist in adult LT recipients. Graft loss may be a consequence. This entity may represent a specific type of rejection that should currently be classified as “graft dysfunction mimicking autoimmune hepatitis.” (Hepatology 2001;34:464-470.)
249 CHANGES IN TUMOR STIFFNESS FOR EARLY PREDICTION OF TUMOR RESPONSE TO SORAFENIB: A PROOF-OF-CONCEPT STUDY WITH ELASTOSONOGRAPHY IN AN ANIMAL MODEL OF HEPATOCELLULAR CARCINOMA (HCC)
Authors: V. Salvatore, M. Baron Toaldo, S. Marinelli, C. Palamà, L. Gramantieri, M. Cipone, L. Bolondi, F. Piscaglia
Journal: Journal of Hepatology (2011)
Non-A, non-B chronic hepatitis is chronic hepatitis C: A sensitive assay for detection of hepatitis C virus RNA in the liver
Authors: Kazuhiko Hosoda, Masao Omata, Osamu Yokosuka, Naoya Kato, Masao Ohto
Journal: Hepatology (1992)

To study the role of hepatitis C virus in non-A, non-B chronic hepatitis, 49 liver biopsy samples from 40 patients with non-A, non-B chronic hepatitis and 9 control patients were analyzed by complementary DNA/polymerase chain reaction. Two segments of the HCV genome, one in the nonstructural region and the other in the noncoding region, were amplified by two sets of primer pairs. With use of the nonstructural region primers, hepatitis C virus RNA was detected in 24 (60%) of 40 patients with non-A, non-B chronic hepatitis. Of these 40 patients, RNA was detected in 19 (70%) of 27 patients positive for antibody to hepatitis C virus and in 5 (38%) of 13 patients negative for antibody to hepatitis C virus. However, with the noncoding region primers, hepatitis C virus RNA was detected in 38 (95%) of 40 patients with non-A, non-B chronic hepatitis. Of these patients, the RNA was detected in 26 (96%) of 27 patients positive for antibody to hepatitis C virus and also in 12 (92%) of 13 patients positive for antibody to hepatitis C virus. Hepatitis C virus RNA was not detected in any of the control patients. Sequence analysis showed homology between our samples and the prototype to be only 66% to 77% in the nonstructural region but 99% to 100% in the noncoding region. We conclude that almost all patients with non-A, non-B chronic hepatitis in Japan are currently infected with hepatitis C virus, regardless of the presence or absence of antibody to hepatitis C virus.(ABSTRACT TRUNCATED AT 250 WORDS)
Design and use of respirators: proceedings of a joint meeting of the Ergonomics Research Society and the British Occupational Hygiene Society held at Porton 5 and 6 July, 1961.
Authors: Lemuel C. McGee
Journal: JAMA (1963)

A respirator is defined as "a breathing apparatus which incorporates a filter and/or absorbent which removes poisonous or unpleasant materials from the air breathed in." "Dust masks" are more vulnerable than are the masks which are devised to protect against gases and vapors, the so-called "canister respirators." The latter received exceptional attention after World War I. For dust masks there is the need to balance penetration by particles of less than a micron in diameter against resistance of the filter to the passage of air. The extent of leakage about the face piece and valve is a problem with all masks. There is acceptance of the variation of faces in size and contour, also differences due to sex and to age. A more precise system for sizing the faces of the wearers, based on linear dimensions as for shirts and shoes, is needed, with a range of face fittings to
SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning
Authors: Elissa M. Robbins, Alexander J. Krupp, Karen Perez de Arce, Ananda K. Ghosh, Adam I. Fogel, Antony Boucard, Thomas C. Südhof, Valentin Stein, Thomas Biederer
Journal: Neuron (2010)
lodine-131 Labeled Anti-CEA Antibodies Uptake by Hurthle Cell Carcinoma
Authors: HANI ABDEL-NABI, GEORGE H. HINKLE, JAMES M. FALKO, DAVID KELLY, JOHN O. OLSEN, EDWARD W. MARTIN
Journal: Clinical Nuclear Medicine (1985)

Localization of Hürthle cell cancer deposits in the lung with l-131 labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody is described. This technique may prove useful if conventional scanning with l-131 sodium iodide for distant metastases is negative.
More Rough Notes, and a Few Facts, for Lord Ashley
Authors: H. W. Livett
Journal: BMJ (1844)

GENTLEMEN,-AS I think the cause of the Profes- sion versus the New Poor-law will be best served by every member of it stating his own peculiar grievance, and suggesting the remedy he judges most appropriate, I will recount mine.The district of which I am medical officer comprises six villages, at the respective distances from my residence of five, three and a half, four, three, four, and four miles.The system of payment adopted is by a permanent list, comprising the old and infirm paupers, thirty-nine in number, at 2s. 6d. per head, sick or well, throughout the year, and, by special cases, 7s.6d. per head.I have copied the following cases, as they stand, at random from one leaf of my weekly report-book, and added the length of time I was in attendance on each:-A.B., marasmus . . . . 10 months.
Contraction in cardiac endothelial cells contributes to changes in capillary dimensions following ischaemia and reperfusion
Authors: M Glyn
Journal: Cardiovascular Research (2000)

Objective: Ischaemia followed by reperfusion brings about a reduction in cardiac capillary cross-sectional dimensions which is consistent with constriction. The aim of this study was to test the hypothesis that the reduction in cardiac capillary dimensions that occurs in ischaemia and reperfusion is caused by endothelial cell contraction and that modulating the endothelial cell contractile apparatus reduces microvascular reperfusion injury. Methods: In isolated rat hearts we used phalloidin to stabilise the endothelial actin filaments in order to prevent the dimensional changes during ischaemia. The changes in endothelial cell dimensions were quantified by measuring whole capillary and luminal cross-sectional areas, abluminal and luminal membrane lengths. We have also used resin casts of the coronary vasculature coupled with scanning electron microscopy to examine the structural changes along the length of the capillaries in ischaemia–reperfusion. Results: We found that the reduction in capillary dimensions was prevented by the addition of phalloidin and, in the resin casts, that ischaemia–reperfusion cause focal narrowings along the capillaries which are consistent with constriction. Conclusions: (1) The endothelial contractile apparatus is involved in the reduction in cross-sectional dimensions. (2) This implies that the capillary bed may have a greater role in the local control of flow than was previously thought and that modulation of the actomyosin contractile system in cardiac capillary endothelial cells may be useful in reducing ‘no reflow’ injury which results from reperfusion.
The Heartbreak of Drug Pricing
Authors: Wes Lisker
Journal: Annals of Internal Medicine (2002)

Letters4 June 2002The Heartbreak of Drug PricingWes Lisker, MDWes Lisker, MDHayward, CA 94545 (Lisker)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-11-200206040-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I would like to thank Dr. Davidoff for his editorial on drug pricing (1). The ends to which pharmaceutical companies will go to achieve ever-greater profits are astonishing. I recently received from Amgen (Thousand Oaks, California) an announcement of another price increase in their product Epogen (erythropoietin). Amgen rationalized this increase by saying that it had not raised prices in several years and that it was merely following the consumer price index. In a recent issue, The Medical Letter noted that Amgen has been using direct-to-consumer advertising for Epogen. There is also a black market for Epogen ...Reference1. Davidoff F. The heartbreak of drug pricing [Editorial]. Ann Intern Med. 2001;134:1068-71. [PMID: 11388821] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Hayward, CA 94545 (Lisker) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe 28th Amendment Frank Davidoff and Robert D. Reinecke The Heartbreak of Drug Pricing Frank Davidoff The Heartbreak of Drug Pricing Frank Davidoff The Heartbreak of Drug Pricing Johnathon S. Ross Metrics 4 June 2002Volume 136, Issue 11Page: 853KeywordsAntiretroviralsChemotherapyDrugsErythropoietinFood and Drug AdministrationHIVMedical dialysisPatients ePublished: 4 June 2002 Issue Published: 4 June 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
We Have Strict Statutes and Most Biting Laws—Reply
Authors: David A. Hyman, William M. Sage
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Challenging and Unusual Cases
Authors: W.Y. Au, W.M. Wong, U.S. Khoo, R. Liang
Journal: Journal of Clinical Oncology (2003)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.05.181 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12663737 Challenging and Unusual Cases CASE 2. CONCURRENT GASTROINTESTINAL STROMAL TUMOR AND BURKITT’S LYMPHOMA W.Y. AuxW.Y. AuSearch for articles by this author , W.M. WongxW.M. WongSearch for articles by this author , U.S. KhooxU.S. KhooSearch for articles by this author , R. LiangxR. LiangSearch for articles by this author Show More Departments of Medicine and Pathology, Queen Mary Hospital, Hong Kong https://doi.org/10.1200/JCO.2003.05.181 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Effect of Overload and Hyperbaric Oxygen on Protein Synthesis in Heart Muscle.
Authors: Sidney S. Schreiber
Journal: Annals of Internal Medicine (1967)

s1 May 1967Effect of Overload and Hyperbaric Oxygen on Protein Synthesis in Heart Muscle.Sidney S. Schreiber, M.D., F.A.C.P., Marcus A. Rothschild, M.D., F.A.C.P., Murray Oratz, Ph.D.Sidney S. Schreiber, M.D., F.A.C.P.Search for more papers by this author, Marcus A. Rothschild, M.D., F.A.C.P.Search for more papers by this author, Murray Oratz, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1038_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProlonged increase in left ventricle contractile action resulting from aortic hypertension or increased cardiac output is associated with hypertrophy and increased protein synthesis, but the mechanism stimulating synthesis is unclear. Using14C-labeled lysine, protein synthesis was measured in the perfused guinea pig heart. Increased fluid load or elevation of aortic pressure without increased load resulted in increased ventricular contractile action and increased14C-lysine incorporation into ventricle protein after 3 hr. Protein synthesis was also augmented in the absence of ventricular overload with increase in direct coronary perfusion. Because of the possible effect of oxygen availability due to increased coronary flow... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1038-1038KeywordsGuinea pigsHeartHyperbaric oxygenHypertensionLeft ventricleLysineMyocardiumOxygenProtein synthesisProteins ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
Mother-to-infant HCV transmission in a Nile Delta community: preliminary results
Authors: S.K. Stoszek, A.D. Fix, S. Narooz, S. El Kafrawy, S.M. Saleh, E. Kassern, Y. Hawash, H. Baligh, I. El Henawy, G.Thomas Strickland
Journal: Journal of Hepatology (2001)
Rinsing the dialyzer.
Authors: W. Drukker
Journal: BMJ (1968)

BMDTCA formation of anticoagulant fibrinogen degradation products aggravates the haematologic defect.Moreover, to control the replacement of fibrinogen, as is suggested, is difficult, since the laboratory tests com- monly employed in acute fibrinolytic conditions (thrombin time, Fibrindex, etc.) are at best semi-quantitative.Even if a rapid method of fibrinogen estimation is used' the findings can be misleading, for the blood level of fibrinogen may be higher than that indicated by the test owing to the presence of anticoagulant fibrinogen degradation pro- ducts.'In our experience in obstetrical patients' ' the clinical condition of the patient may be a better guide to therapy than the fibrinogen level determined in the laboratory, and fresh whole blood is a better substitute than fibrinogen alone.Lastly, the risk of E.A.C.A. causing intravascular thrombosis (apart from that presented by the original stimulus for defibrination) when it is given for a rela- tively short period (as in acute obstetrical conditions) is negligible.This is because the drug is excreted through the kidneys very rapidly.-Iam, etc.,
Hemorrhage in the Upper Digestive Tract Caused by an Aorto-Esophageal Fistula
Authors: M. Alcantara, J. M. Carrobles, J. L. M. Potenciano, J. M. Chacon, L. Garcia, M. A. Cuesta
Journal: Endoscopy (1990)

The case of a 75-year-old patient admitted to our Center with hematemesis is presented. At oral endoscopy a pulsating vegetative mass was found in the distal third of the esophagus, which aroused suspicion of an aortic aneurysm fistulized to the esophagus; this was confirmed by arteriography. He underwent two surgical procedures, the aneurysm being resected and replaced by an aortic prosthesis, and esophagectomy performed. The patient died of postoperative complications. The endoscopic appearance is shown.
The view from Ulm minster
Authors: J. O. Drife
Journal: BMJ (1995)

We had not specially planned to be in Germany on VE day. Nor had we expected to climb Ulm cathedral spire, the tallest in the world. By the time I passed the bells I was sure I was going to die. At the top I peered down through my sweat at the town's reconstructed buildings. Eighty per cent of Ulm's houses had been destroyed by wartime bombing but its minster had been spared. I was surprised that in 1944 it had been possible to incinerate civilians with such finesse.

Our group of doctors regularly travels abroad but this was the first …
SUPPURATIONS OF THE PETROUS TIP
Authors: EDMUND P. FOWLER
Journal: JAMA (1934)

The symptoms and signs, the essential pathologic changes and the treatment of simple mastoiditis are known to physicians throughout the world. In the last few years, otologic journals have contained many reports of a similar but somewhat more obscure disease of the temporal bone; namely, petrositis or inflammation of the petrosal portion of the bone. During the four years that routine serial sections of the temporal bones have been done in the Department of Pathology of the Presbyterian Hospital, six cases of meningitis of otic origin have been sectioned out of 1,165 general autopsies. All these patients had petrositis.<sup>1</sup>Four of the six proved cases were from the medical wards and two from the ear service. This suggests that the disease might be of considerable interest to the general medical man. Suppurations of the temporal bone other than those in the middle ear, mastoid and zygoma have been recognized
Ionising radiation in infancy and adult cognitive function
Authors: Sanjay P Prabhu
Journal: BMJ (2004)

Editor—The study by Hall et al on ionising radiation in childhood is flawed for several reasons.1

Firstly, exposure to radiation in 1930-60 was without adequate collimation and shielding, and the machines used were far less accurate than recent models.

Secondly, the x ray treatments entailed mainly contact therapy at low (60 kVp) voltage, which means less penetration and lower energy photons, which are absorbed more in tissue. Some children were treated more than once, either by receiving several treatments for one haemangioma or by receiving individual treatments for several haemangiomas. This would have a stochastic effect. Today's average patient is not exposed to anything resembling what the paper quotes.

Thirdly, no consistent difference was seen between the two lowest dose categories (1-20 mGy and > 20-100 mGy), but the increment of exposure was limited, with median values of only 0 and 30-40 mGy. These are the maximum levels of exposure on computed tomography, and this is further reduced with newer scanners and dose reduction protocols based on infant age and body weight. The dose in computed tomography varies with both equipment and operator dependent factors.2,3

Fourthly, in the United Kingdom computed tomography is opted for in young children only after considering national and international guidelines. Various strategies exist to limit the radiation dose.4,5 However, it would be far preferable to have computed tomography to rule out serious intracranial disease than worry about the loss of a couple of IQ points in later life in a child with serious clinical signs.

This paper is another example of the BMJ publishing an article to gain publicity in the media by sensationalising an issue.
DIAGNOSIS, PREVENTION AND TREATMENT OF PUERPERAL INFECTION.
Authors: FREDERICK HOLME WIGGIN
Journal: JAMA (1902)

tion is not only puzzling and tedious but, should the case be one of emergency, his work will be well-nigh im- possible.The threads become tangled, knotted, twisted and mixed.The gut gets bruised and pulpified by pro- longed manipulation, devitalized and leaky from punc- tures and cuts of needles while the surgeon himself becomes exhausted and more tangled up than his sutures.The "average surgeon," or "occasional operator," as the patronizing expert calls him, will find himself far better satisfied with a simple comprehensive and rapidly applicable device than with one of the above mentioned brilliant and complicated intricacies.To him I would respectfully dedicate my coupler.
Recurrence of angina after coronary artery bypass surgery: Predictors and prognosis (CASS registry)
Authors: Airlie A.C. Cameron, Kathryn B. Davis, William J. Rogers
Journal: Journal of the American College of Cardiology (1995)

This study sought to define the predictors and prognosis of postoperative angina in patients undergoing coronary artery bypass surgery. Angina recurs in the first postoperative year in 20% to 30% of patients after coronary artery bypass surgery. The Coronary Artery Surgery Study Registry provides an opportunity to study the predictors and prognosis of postoperative angina in a large sample. All patients with isolated coronary artery bypass surgery in the registry were identified, and anginal status was determined on a yearly basis. The influence of angina on mortality, recurrent myocardial infarction and need for reoperation was determined. Angina recurred in the first year in 24% of patients and by the sixth year in 40%. The significant predictors in a multivariate analysis were minimal coronary artery disease, preoperative angina, use of vein grafts only, previous myocardial infarction, incomplete revascularization, female gender, smoking and younger age. In subsequent years important predictors were angina in the first postoperative year, female gender, younger age and incomplete revascularization. The presence of angina in the first postoperative year was associated with more frequent myocardial infarction (p = 0.04) and greater need for reoperation (p = 0.003) but did not affect survival during the 6-year follow-up period. These findings show that the predictors of postoperative angina are features that are or could be predicted before bypass surgery. Thus, patients with these features before bypass surgery could be advised that they would be more likely to experience postoperative angina than those without these features. Postoperative angina is associated with an increased risk of late myocardial infarction and reoperation.