tbuckley/cabot-search huggingface dataset:
Ferrous Sulfate Tolerance Test: A Case Report
Authors: Omaya H. Youssef, Almond J. Drake, K.M. Mohamed Shakir
Journal: Annals of Internal Medicine (1999)

Letters15 June 1999Ferrous Sulfate Tolerance Test: A Case ReportOmaya H. Youssef, BSc, MSC, USAR, Almond J. Drake III, MD, MC, USN, and K.M. Mohamed Shakir, MD, MC, USNOmaya H. Youssef, BSc, MSC, USARNational Naval Medical Center; Bethesda, MD 20889 (Youssef)National Naval Medical Center; Bethesda, MD 20889 (Drake)National Naval Medical Center; Bethesda, MD 20889 (Shakir)Search for more papers by this author, Almond J. Drake III, MD, MC, USNNational Naval Medical Center; Bethesda, MD 20889 (Youssef)National Naval Medical Center; Bethesda, MD 20889 (Drake)National Naval Medical Center; Bethesda, MD 20889 (Shakir)Search for more papers by this author, and K.M. Mohamed Shakir, MD, MC, USNNational Naval Medical Center; Bethesda, MD 20889 (Youssef)National Naval Medical Center; Bethesda, MD 20889 (Drake)National Naval Medical Center; Bethesda, MD 20889 (Shakir)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The unfavorable response to enteric-coated iron tablets and the alternate use of oral ferrous sulfate solution for treating iron deficiency anemia in some patients have been previously reported (1). Another study showed that the bioavailability of iron in commercially available enteric-coated preparations is lower than that of oral iron solutions (2).We describe a 33-year-old woman with a 15-year history of iron deficiency anemia. Numerous courses of treatment with oral ferrous sulfate tablets had failed, despite a pill count that suggested compliance. The patient had no history of gastrectomy, celiac disease, or H2-blocker or antacid use, and ...References1. Rudinskas L, Paton T, Walker S, Dotten D, Cowan D. Poor clinical response to enteric-coated iron preparations. Can Med Assoc J. 1989;141:565-6. Google Scholar2. Walker S, Paton T, Cowan D, Manuel M, Dranitsaris G. Bioavailability of iron in oral ferrous sulfate preparations in healthy volunteers. Can Med Assoc J. 1989;141:543-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: National Naval Medical Center; Bethesda, MD 20889 (Youssef)National Naval Medical Center; Bethesda, MD 20889 (Drake)National Naval Medical Center; Bethesda, MD 20889 (Shakir) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1999Volume 130, Issue 12Page: 1030KeywordsBloodGastrectomyGastroenterology and hepatologyHematocritHemoglobinIron deficiency anemiaResearch laboratoriesSerum ferritin levelsSulfatesTea Issue Published: 15 June 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Time Dependence of Defibrillator Benefit After Coronary Revascularization in the Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II
Authors: Ilan Goldenberg, Arthur J. Moss, Scott McNitt, Wojciech Zareba, W. Jackson Hall, Mark L. Andrews, David J. Wilber, Helmut U. Klein
Journal: Journal of the American College of Cardiology (2006)
High-dose interferon, sentinel lymph node biopsy and the U.K. guidelines for cutaneous melanoma: reply from authors
Authors: J.A. Newton Bishop, P.G. Corrie, J. Evans, M.E. Gore, P.N. Hall, N. Kirkham, D.L.L. Roberts, A.V. Anstey, R.J. Barlow, N.H. Cox
Journal: British Journal of Dermatology (2002)
Human β-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis
Authors: M.-L. Clausen, J.M. Jungersted, P.S. Andersen, H.-C. Slotved, K.A. Krogfelt, T. Agner
Journal: British Journal of Dermatology (2013)

Skin infections related to disrupted antimicrobial defence are a common problem in atopic dermatitis (AD). Altered levels of antimicrobial peptides, including human β-defensin (hBD)-2, have been reported in AD skin, and a link to impaired barrier function has been suggested.To study hBD-2 in relation to skin barrier function in patients with AD and controls, and to study hBD-2 in relation to disease severity.Twenty-five patients with AD and 11 controls were enrolled. hBD-2 peptide concentration was determined in stratum corneum samples collected by a minimally invasive tape-stripping method. Disease severity was assessed by SCORing Atopic Dermatitis (SCORAD), and skin barrier function was evaluated by measurement of transepidermal water loss (TEWL) and skin pH. Patients with AD were characterized according to filaggrin mutations.hBD-2 concentrations in the stratum corneum were found to differ between lesional and nonlesional AD skin and controls, with the highest values in lesional skin (P < 0·001). SCORAD and TEWL were significantly increased in participants with measureable hBD-2 (P < 0·018 and P < 0·007, respectively). Significant correlations between hBD-2 in lesional skin, and TEWL and SCORAD were observed (R = 0·55 and R = 0·44, respectively). No correlations with skin pH were found. hBD-2 was not found to relate to filaggrin mutations.A significant correlation was found between hBD-2, disturbed skin barrier function and disease severity. The minimally invasive skin sample technique enables evaluation of the stratum corneum and its proteins over time and provides the possibility of relating these findings to treatment, infections and physiological variations.
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
Authors: Ze Tian, Padraig D’Arcy, Xin Wang, Arghya Ray, Yu-Tzu Tai, Yiguo Hu, Ruben D. Carrasco, Paul Richardson, Stig Linder, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood (2013)
Ultrastructural studies of myeloma cells: Observations concerning the Golgi apparatus and intermediate‐size filaments
Authors: Margit Pavelka, Heinz Ludwig
Journal: American Journal of Hematology (1983)

Abstract Studies on the ultrastructure of tumor cells of 22 multiple myeloma patients revealed hitherto unreported observations concerning the Golgi apparatus and intermediate‐size filaments. Various abnormalities of the Golgi apparatus including displacements of the Golgi stacks, dilatations of cisternae, and massive accumulations of vesicles as well as vacuoles in the Golgi region were found in myeloma cells of 11 patients. Intermediate‐size filaments forming a fine intracytoplasmic network were apparent in myeloma cells of all 22 patients. In five patients, in addition to this architecture, intermediate‐size filaments were gathered into thick bundles which were primarily but not exclusively located in the perinuclear region.
Reproductive Freedom and the Next President
Authors: Eli Y. Adashi, Darrell M. West
Journal: New England Journal of Medicine (2008)

Dr. Eli Adashi and Darrell West discuss how the national debate about “reproductive freedom” has evolved to include the use of human embryos for stem-cell research, the assurance of access to family-planning services and comprehensive sex education, and the Partial-Birth Abortion Ban Act.
Role of caspases in male infertility
Authors: Tamer M Said, Uwe Paasch, Hans-Juergen Glander, Ashok Agarwal
Journal: Human Reproduction Update (2004)

Apoptosis is characterized by a variety of changes resulting in the recognition and phagocytosis of apoptotic cells. Caspases (cysteinyl aspartate-specific proteinases) play a central role in the regulation of apoptosis in the human seminiferous epithelium. They are expressed as inactive proenzymes and participate in a cascade triggered in response to pro-apoptotic signals. To date, 14 caspases have been implicated in the human apoptotic pathway cascade. Among these, caspase-3 is considered to be a major executioner protease. Since apoptosis is a universal suicide system in almost all cells, a close control via molecular, endocrine and physical factors establishes homeostasis of cell growth and death. The proper regulation of the caspase cascade plays an important role in sperm differentiation and testicular maturity. However, caspases have been implicated in the pathogenesis of multiple andrological pathologies such as impaired spermatogenesis, decreased sperm motility and increased levels of sperm DNA fragmentation, testicular torsion, varicocele and immunological infertility. Future research may provide a better understanding of the regulation of caspases, which may help us to manipulate the apoptotic machinery for therapeutic benefits. In this review, we summarize the consequences of caspase activation, aiming to clarify their role in the pathogenesis of male infertility.
Changes in Occupation After Aortocoronary Vein-Bypass Operation
Authors: Alfred A. Rimm
Journal: JAMA (1976)

The effect of aortocoronary vein-bypass operation on changes in occupational status was investigated in a cohort of 893 men. The median period of time between the operation and follow-up evaluation of postoperative occupational status was 14 months. The patients were divided into two age groups, with 55 years as the dividing point. The results showed that 11% of the younger men and 26% of the older group who were employed before the operation retired following the operation. In addition, 30% of the patients changed their occupational status following the operation. When occupational changes also resulted in changes in physical demands, 49% of the patients took new jobs that were less demanding physically, while 40% took jobs that were more demanding. Close to 9% of the patients were retired prior to the operation; about one fifth of them came out of retirement following the operation. (<i>JAMA</i>236:361-364, 1976)
Supraventricular Tachycardia After Orthotopic Cardiac Transplantation
Authors: Marmar Vaseghi, Noel G. Boyle, Rohit Kedia, Jignesh K. Patel, David A. Cesario, Isaac Wiener, Jon A. Kobashigawa, Kalyanam Shivkumar
Journal: Journal of the American College of Cardiology (2008)
Bimodality of 2-h Plasma Glucose Distributions in Whites
Authors: Juanjuan Fan, Susanne J. May, Yue Zhou, Elizabeth Barrett-Connor
Journal: Diabetes Care (2005)

OBJECTIVE—Several studies have shown a bimodal curve in the distribution of glucose in populations with a high prevalence of type 2 diabetes, but bimodality has not been reported among whites of Northern European ancestry. It is not clear whether this difference reflects the lower prevalence of diabetes, obscuring a second mode, or implies a more fundamental difference between whites and nonwhites. We investigate this issue by studying glucose distributions in older white patients. RESEARCH DESIGN AND METHODS—A study of diabetes was conducted among older community-dwelling white residents of a suburban Southern California community between 1984 and 1987. Two-hour plasma glucose data were collected from 2,326 older white men and women aged 23–92. To investigate bimodality of glucose distributions, we fit unimodal and bimodal normal models to 2-h plasma glucose concentrations transformed by the Box-Cox family of transformations. RESULTS—We found that the bimodal normal mixture model fit the data significantly better than the unimodal skewed distribution model for both sexes and all age-groups except those ≥80 years. The cut points separating the two modes were generally within the 11.1- to 13.6-mmol/l range. CONCLUSIONS—The bimodality of glucose distributions among whites, combined with previous findings, indicates that this phenomenon may be universal. A smaller second mode in our study compared with other studies suggests that whites have diabetes susceptibility but may require more obesity to demonstrate it. With increasing obesity in the U.S., the predicted epidemic of diabetes may affect all ethnic groups including whites.
A new French paradox: HBV vaccination
Authors: Alain Braillon
Journal: Journal of Hepatology (2009)

In his recent article, DS Chen indicated that the hepatitis B vaccine was an innovation from France [[1]Chen D.S. Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B.J Hepatol. 2009; 50: 805-816Abstract Full Text Full Text PDF PubMed Scopus (189) Google Scholar]. When listing the challenges that need to be overcome to extend hepatitis B mass vaccination he could have cited France again. The percentage of one-year-olds immunized with three doses of Hepatitis B in France was 29% in 2006 (vs. 86% in Germany, a comparable country), lower than most of the very poor countries in the world [[2]Data available at http://www.who.int/whosis/data/.Google Scholar]. Recently, a paper by a French team published in a major journal concluded that “Engerix B vaccine appears to increase the risk of CNS inflammatory demyelination in childhood” [[3]Mikaeloff Y. Caridade G. Suissa S. Tardieu M. Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood.Neurology. 2009; 72: 873-880Crossref PubMed Scopus (131) Google Scholar]. A pre-publication release campaign worsened the message in the newspapers. This research was conducted with public funding from several major national bodies. Evaluation could have helped avoiding: (a) subgroup analyses without a priori definition on the basis of known mechanisms or in response to previous findings; (b) absence of declaration of the number of analyses performed; (c) lack of adjustment for multiple testing with tests for heterogeneity [[4]Braillon A, Dubois G. Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood. http://www.neurology.org/cgi/eletters/72/10/873#38119.Google Scholar]. These pitfalls are easy to remember: Sleight showed, in a subgroup analysis of patients from the ISIS- 2 trial, that aspirin therapy was significantly beneficial for all patients except those born under the astrological signs of Gemini or Libra [[5]Sleight P. Subgroup analyses in clinical trials: fun to look at – but don’t believe them!.Curr Control Trial Cardiovasc Med. 2000; 1: 125-127Crossref Scopus (116) Google Scholar]! Guidelines were generated to improve quality of epidemiological studies (eg ‘STrengthening the Reporting of OBservational studies in Epidemiology’ (STROBE) [[6]Data available at http://www.strobe-statement.org/.Google Scholar]. Funding agencies, reviewers and journals editors must have actively endorsed these guidelines.
Immune response of Lewis rats to peptide C1 (residues 68-88) of guinea pig and rat myelin basic proteins.
Authors: R F Kibler, R B Fritz, F Chou, Jen Chou C-H, N Y Peacocke, N M Brown, D E McFarlin
Journal: The Journal of Experimental Medicine (1977)

Peptide C1 (residues 68-88) from GP and rat BP differ by a single amino acid interchange at residue 79. This residue is serine in GP C1 and threonine in rat C1. GP C1 was encephalitogenic in Le rats at doses as low as 15 ng. Rat C1 was encephalitogenic at doses of 1,500 ng or greater. LNC from rats challenged with 25 X 10(-4) micronmol of GP C1 and 250 X 10(-4) micronmol of rat C1 showed a proliferative response in vitro to both peptides, but in each instance the magnitude of the response was greater to the GP peptide. GP C1 also induced higher levels of circulating antibodies at 25 X 10(-4) micronmol, but the specificity of antibodies produced by the two peptides was the same. These results have been interpreted as indicating that the presence of serine at position 79 in GP C1 results in the stimulation of greater numbers of T cells involved in (a) the induction of EAE, (b) the in vitro proliferative response and (c) helper function in antibody production.
Health Pros Want New Rules for Girl Athletes
Authors: Andrew A. Skolnick
Journal: JAMA (1996)

THE CENTENNIAL Olympic Games anticipated occurrence in Atlanta, Ga, this summer serves as a focus for new emphasis on several aspects of sports medicine.  While there is increasing recognition of the right of women to participate in sports on all levels, there is also growing awareness that biological differences between the sexes may require different training rules and practices for men and women—especially for young  athletes.  Research findings presented at the Third International Olympic Committee (IOC) World Congress on Sport Sciences, held in Atlanta, suggest that when it comes to competitive sports, what's good for the gander may in some cases be unhealthy for the goose.  Of particular concern is the potentially fatal group of disorders called female athlete triad, which includes disordered eating behavior, amenorrhea, and osteoporosis ( JAMA . 1993;270:921-923). In addition, certain common competitive training practices have been associated with the development of depression, drug addiction, and other
Young Adults With Head and Neck Cancer Express Increased Susceptibility to Mutagen-lnduced Chromosome Damage
Authors: Stimson P. Schantz
Journal: JAMA (1989)

Factors that contribute to an increased prevalence of squamous cell carcinoma of the upper aerodigestive tract among young adults in the United States remain unknown. A potential etiologic factor may relate to a genetically controlled sensitivity to environmental carcinogens. This study, therefore, examined 20 young adult patients who had squamous cell carcinoma for mutagen-induced chromosome sensitivity. Lymphocytes from respective patients were cultured, exposed to the clastogen bleomycin, arrested during metaphase, and examined quantitatively for chromosome breakage. As compared with an age- and sexmatched control population, as well as a population of patients who had non— squamous cell carcinoma head and neck tumors, the young adult population with squamous cell carcinoma expressed a significantly increased number of bleomycin-induced chromosome breaks per cell. Furthermore, among the study patients, chromosome sensitivity was most apparent in the non—tobacco users and in patients less than 30 years of age. The expression of such chromosome fragility following mutagen exposure should be considered in epidemiologic studies that intend to define risk factors for development of head and neck cancer. (<i>JAMA</i>. 1989;262:3313-3315)
The Relation of Transient Hypothyroxinemia in Preterm Infants to Neurologic Development at Two Years of Age
Authors: Mary Lynne Reuss, Nigel Paneth, Jennifer A. Pinto-Martin, John M. Lorenz, Mervyn Susser
Journal: New England Journal of Medicine (1996)

Transient hypothyroxinemia, a common finding in premature infants, is not thought to have long-term sequelae or to require treatment. We investigated whether hypothyroxinemia in premature infants is a cause of subsequent motor and cognitive abnormalities.
Altered thiol and calcium homeostasis in oxidative hepatocellular injury
Authors: Giorgio Bellomo, Sten Orrenius
Journal: Hepatology (1985)

Perturbation of cellular thiol homeostasis occurs during the early phase of oxidative cell injury in isolated hepatocytes.This perturbation, involves depletion of soluble and protein-bound thiols, and is associated with altered intracellular calcium (Ca") homeostasis resulting from inhibition of major Ca2+ transport systems.The result is sustained increase in cytosolic Ca2+ concentration which appears to trigger cytotoxicity.The step-wise reduction of molecular oxygen to water results in formation of several, potentially toxic, intermediates, including superoxide anion-free radical, hydrogen peroxide and the hydroxyl radical:O2 + ee 0; 0; + e-+ 2H' + H202 H202 + e-+ H' e OH. + H20 OH. + e-+ H' + H20
Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma
Authors: B Arnulf, S Lecourt, J Soulier, B Ternaux, M-Noelle Lacassagne, A Crinquette, J Dessoly, A-K Sciaini, M Benbunan, C Chomienne, J-P Fermand, J-P Marolleau, J Larghero
Journal: Leukemia (2006)
THE VITAMIN B1 REQUIREMENT DURING INSULIN SHOCK THERAPY
Authors: WALTER GOLDFARB, KARL M. BOWMAN
Journal: American Journal of Psychiatry (1941)

Evidence has been presented that certain EKG changes which occur during the course of insulin shock therapy are not due to the administration of insulin, per se, but are due to the fact that large amounts of glucose, a vitamin free substance, are used to rouse the patients from coma. It seems probable that the large caloric intake free of vitamin B caused a relative insufficiency, and that the EKG changes are due to the vitamin B deficiency.
A case of adult blaschkitis with features of interface dermatitis
Authors: S-H. Han, H-J. Song, W-K. Hong, H-S. Lee, G-S. Choi, J-H. Shin
Journal: British Journal of Dermatology (2008)

Conflicts of interest: none declared. Sir, Adult blaschkitis is a rare, relapsing linear eruption of pruritic papules and vesicles. The lesions involve multiple sites, particularly the trunk, and follow Blaschko's lines.1 2–3 Blaschkite de l'adulte and acquired relapsing self‐healing Blaschko dermatitis have been suggested as alternative names for this condition.1, 2 Seven cases have been reported in the literature since it was first described in 1990 by Grosshans and Marot, and the histopathological findings were those of spongiotic dermatitis.1 2–3 We present a case of adult blaschkitis with the histopathological features of interface dermatitis. A 31‐year‐old man presented with a 1‐month history of unilateral pruritic skin disease. He had no history of atopic dermatitis, psoriasis, or any other dermatitis. He had no significant past medical or drug use history. Physical examination revealed discrete erythematous grouped papules and vesicles on the left sides of the trunk and upper and lower limbs. The skin lesions formed whorls and streaks along Blaschko's lines (Fig. 1). A punch biopsy from an abdominal lesion revealed hyperkeratosis, focal parakeratosis, acanthosis, and scattered dyskeratotic cells with basal cell vacuolar degeneration in the epidermis. Spongiosis and lymphocyte exocytosis were also found. Superficial perivascular lymphocytic infiltrates were seen in the dermis (Fig. 2). A short course of oral corticosteroids (20 mg daily) and topical corticosteroid lotion were prescribed. The existing skin lesions improved; however, new lesions developed. His skin lesions cleared with the addition of narrowband ultraviolet B phototherapy (total 6250 mJ, twice a week for 2 months).
Toward a bioartificial kidney: will embryonic stem cells be the answer?
Authors: Carol A. Pollock
Journal: Kidney International (2013)

Directing the development of human embryonic stem cells into functional renal tubular cells has been limited by the lack of defined, reproducible differentiation and culture protocols. If these cells are to be used for in vitro testing or therapeutics, viability under bioreactor conditions is required. Narayanan et al. describe in detail such methodology. Such knowledge will hopefully accelerate the development of the Holy Grail of nephrology, the bioartificial kidney.
Women Medical Students
Authors: Ferris N. Pitts
Journal: JAMA (1978)

To the Editor.—  There have been significant increases in both numbers and percentages of medical students who are women in the past decade.1These increases have resulted from numerous minority rights federal court decisions and the minority admissions demands placed on US medical schools by the federal capitation financial support programs. (These programs also mandated increases in numbers of medical students.)2The post hoc self-congratulation for this progressive reform by medical educators and the medical politicians is suspect, since there is not a shred of evidence that these changes would have occurred without the mandate associated with the capitation support. This letter is written to emphasize, by demonstrating the actual numbers and percentages, how little has actually been achieved, even though women physicians and medical educators and politicians are apparently delighted.2  Tables 1 and 2 show that the number of women medical students increased by a factor