tbuckley/cabot-search huggingface dataset:
Breast Tissue Ablation Device
Authors: Bernard A. Schwetz
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epithelioma of the Male Urethra Following Injury
Authors: R. T. Cooke
Journal: BMJ (1952)

been arrested by terramycin became reinfected after a week's interval, and was not seen again until he had begun to whoop.These cases show that pertussis arrested by treat- ment may not be followed by immunity.Group 11 consisted of 14 children treated early in the paroxysmal stage.Paroxysms continued for periods ranging from 6 to 33 days.Their total duration of cough ranged from 12 to 46 days.In one case segmental pulmonary collapse was noted after treatment.Group III consisted of 11 cases of pertuissis given no anti- biotic.Four failed to develop a paroxysmal stage and their total duration of cough ranged from 21 to 40 days.In the seven paroxysmal cases paroxysms occurred for periods ranging from 4 to 31 days, and the total duration of cough ranged from 30 to 49 days. COMMENTThese results suggest that terramycin given early in the pre-paroxysmal stage can, like chloramphenicol, modify and arrest the course of pertussis.The onset of paroxysms may be averted and the duration of the illness and infectivity is shortened.Immunity may not follow arrest of the illness in the pre-paroxysmal stage, and for ultimate protection immunization may still be advisable.These results are comparable to those previously obtained with chloram- phenicol in pertussis contacts, and suggests that terramycin may be used as an alternative if its value is confirmed by more extensive trials.
E-selectin ligand–1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-β
Authors: Tao Yang, Roberto Mendoza-Londono, Huifang Lu, Jianning Tao, Kaiyi Li, Bettina Keller, Ming Ming Jiang, Rina Shah, Yuqing Chen, Terry K. Bertin, Feyza Engin, Branka Dabovic, Daniel B. Rifkin, John Hicks, Milan Jamrich, Arthur L. Beaudet, Brendan Lee
Journal: Journal of Clinical Investigation (2010)

The majority of human skeletal dysplasias are caused by dysregulation of growth plate homeostasis. As TGF-beta signaling is a critical determinant of growth plate homeostasis, skeletal dysplasias are often associated with dysregulation of this pathway. The context-dependent action of TFG-beta signaling is tightly controlled by numerous mechanisms at the extracellular level and downstream of ligand-receptor interactions. However, TGF-beta is synthesized as an inactive precursor that is cleaved to become mature in the Golgi apparatus, and the regulation of this posttranslational intracellular processing and trafficking is much less defined. Here, we report that a cysteine-rich protein, E-selectin ligand-1 (ESL-1), acts as a negative regulator of TGF-beta production by binding TGF-beta precursors in the Golgi apparatus in a cell-autonomous fashion, inhibiting their maturation. Furthermore, ESL-1 inhibited the processing of proTGF-beta by a furin-like protease, leading to reduced secretion of mature TGF-beta by primary mouse chondrocytes and HEK293 cells. In vivo loss of Esl1 in mice led to increased TGF-beta/SMAD signaling in the growth plate that was associated with reduced chondrocyte proliferation and delayed terminal differentiation. Gain-of-function and rescue studies of the Xenopus ESL-1 ortholog in the context of early embryogenesis showed that this regulation of TGF-beta/Nodal signaling was evolutionarily conserved. This study identifies what we believe to be a novel intracellular mechanism for regulating TGF-beta during skeletal development and homeostasis.
ULCERATIVE VULVITIS AND STOMATITIS OF ENDOCRINE ORIGIN
Authors: A. J. Ziserman
Journal: JAMA (1935)

The coexistence of nonvenereal ulcerative lesions of the mouth and genitalia was originally reported by Neumann.<sup>1</sup>A comprehensive review of this rare condition was recently presented by Wien and Perlstein,<sup>2</sup>who collected a total of twenty-nine cases from the literature and reported in addition a personal case, which was the first to be recorded in this country. There has been considerable variation of opinion regarding the etiology of this condition. One of the theories attributes the ulcerative lesions to an angioneurosis caused by ovarian dysfunction.<sup>3</sup>Although the usual coexisting menstrual disorder gives plausibility to this belief, there has been no attempt at a therapeutic test to verify this theory. This case is reported because the therapeutic result obtained points to a possible endocrine etiology of the disorder and also because of the rarity of the rarity of the condition. M. M., a woman, aged 23, seen in July 1932, complained
FUNCTIONAL ASSESSMENT BY STRESS EXERCISE IN PATIENTS WITH ANOMALOUS AORTIC ORIGIN OF A CORONARY ARTERY: EXPERIENCE OVER 17 YEARS
Authors: Silvana M. Lawrence, Carlos M. Mery, Muhammad S. Khan, Amanda L. Tate, Diane W. Chen, Rajesh Krishnamurthy, Charles D. Fraser
Journal: Journal of the American College of Cardiology (2013)
Interspecific hybridization increases transposition rates of Osvaldo
Authors: M. Labrador, M. Farre, F. Utzet, A. Fontdevila
Journal: Molecular Biology and Evolution (1999)

Several authors have postulated that genetic divergence between populations could result in genomic incompatibilities that would cause an increase in transposition in their hybrids, producing secondary effects such as sterility and therefore starting a speciation process. It has been demonstrated that transposition largely depends on intraspecific hybridization for P, hobo, and I elements in Drosophila melanogaster and for several elements, including long terminal repeat (LTR) and non-LTR retrotransposons, in D. virilis. However, in order to demonstrate the putative effect of transposable elements on speciation, high levels of transposition should also be induced in hybrids between species that could have been originated by this process and that are still able to interbreed. To test this hypothesis, we studied the transposition of the LTR retrotransposon Osvaldo in Drosophila buzzatii-Drosophila koepferae hybrids. We used a simple and robust experimental design, analyzing large samples of single-pair mate offspring, which allowed us to detect new insertions by in situ hybridization to polytene chromosomes. In order to compare transposition rates, we also used a stock recently obtained from the field and a highly inbred D. buzzatii strain. Our results show that the transposition rate of Osvaldo is 10(-3) transpositions per element per generation in all nonhybrid samples, very high when compared with those of other transposable elements. In hybrids, the transposition rate was always 10(-2), significantly higher than in nonhybrids. We show that inbreeding has no effect on transposition in the strains used, concluding that hybridization significantly increases the Osvaldo transposition rate.
Comment
Authors: Philip Rubin
Journal: JAMA (1968)

The interrelationship between cure and the growth rate of human tumors is generally appreciated. However, the selection of five-year survival figures as a reference point in time for cure of cancer is arbitrary since many exceptions exist. For the slow growing tumor, such as thyroid cancer, only 10-or even 15-year survival rates are helpful. For rapidly growing lesions, such as the childhood tumors under discussion, two-year survival rates are meaningful. But many exceptions exist to general rules about a specific histopathologic type of cancer, and the clinician is always searching for a more objective measure to predict the prognosis of each individual patient. The concept of "doubling times" as a measure of growth rate of human tumors and its utilization as a prognosticator in childhood cancers is an intriguing and important insight. Collins et al<sup>51</sup>hypothesized that the origin of a cancer is from a single cell which divides
Melanoma surveillance in the United States: Overview of methods
Authors: Meg Watson, Christopher J. Johnson, Vivien W. Chen, Cheryll C. Thomas, Hannah K. Weir, Recinda Sherman, Myles Cockburn, Jeannette Jackson-Thompson, Mona Saraiya
Journal: Journal of the American Academy of Dermatology (2011)

Skin cancer is the most common form of cancer in the United States. Melanoma skin cancer is particularly deadly; more than 8000 US residents die from it each year. Although recent reports suggest that melanoma incidence rates have been increasing, these apparent increases could be caused by an increase in reporting and/or screening, and by an actual increase in the occurrence of melanoma.In this report, we describe methods used in this supplement to assess the current burden of melanoma in the United States using data from two federal cancer surveillance programs: the Centers for Disease Control and Prevention (CDC) National Program of Cancer Registries and the National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results program. We also provide basic descriptive epidemiologic data about melanoma in the United States.Cancer incidence data from population-based cancer registries that participate in the CDC National Program of Cancer Registries and/or the NCI Surveillance, Epidemiology, and End Results Program covering 78% of the US population for 2004 to 2006 were used.Over 45 thousand melanomas were diagnosed annually, with a rate of 19 cases per 100,000 persons.Melanoma rates may vary because of differences in reporting, diagnosis, and screening.To our knowledge, the articles in this supplement constitute the first comprehensive examination of the overall burden of melanoma in the United States based on data from a majority of the US population.
Reversal of chronic regional myocardial dysfunction (hibernating myocardium) by synchronized diastolic coronary venous retroperfusion during coronary angioplasty
Authors: Istvan Hajduczki, Sheila Kar, Joseph Areeda, Lars Ryden, Stephen Corday, Roberto Haendchen, Eliot Corday
Journal: Journal of the American College of Cardiology (1990)
Experience From Sweden
Authors: Sigmund J. Lofstead
Journal: JAMA (1975)

<h3>To the Editor.—</h3> As a newly immigrated Swedish general practitioner in this country, I am both amused and saddened to observe the intense and sometimes inflamed debate over issues like National Health Insurance and socialization of medicine in the United States. There are virtually no pros and cons in the arguments that I did not hear over and over again as a part of the struggle that preceded the Swedish reform. Now, after a few years of testing the Swedish experiment, it is striking to see the negative effects that neither the advocates nor the opponents of government take-over were able to foresee. Summing up, the experience is saddening: the quality of health care, generally, has not been affected positively. A governmental and bureaucratic superstructure has created incredible waiting lines for specialty care (heavily centralized). It is not unusual to wait a year or more for a cataract operation. Primary
Getting the NHS back on course.
Authors: H Stevens
Journal: BMJ (1978)

This situation occurs because points for medical problems contribute little to the points total.Data from six housing authorities in Wales (see table) that use the points system show that the total number of points which can be granted on medical grounds, and therefore the effectiveness of normal medical intervention, varies markedly.'Within these authorities the maximum number of medical points attainable as a percentage of the lowest Vaclue of miiedical points in relati'oni to qucallfing thrXeslhold for rehousislg in six housing authorities in lt"ales* Qualifying Maximum Maximum threshold medical Housinig illedical for points aulthorit!
Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand–receptor complexes
Authors: Stephen J. Briddon, Stephen J. Hill
Journal: Trends in Pharmacological Sciences (2007)

Recent years have revealed a high degree of structural organisation in the way in which cell-surface receptors and their associated signalling complexes interact at a molecular level. Fluorescence-based techniques have been at the forefront of methodologies used to investigate this organisation and dissect the pharmacology of drug-receptor interactions at the single-cell level. One such technique, fluorescence correlation spectroscopy (FCS), in conjunction with a fluorescent ligand or receptor, is capable of providing quantitative information about the number of receptors and their mobilities within small areas of the cell membrane that approach the size of some signalling domains. This article describes the use of FCS to perform subcellular quantitative pharmacology, with particular reference to G-protein-coupled receptors (GPCRs). In conjunction with other forms of fluctuation analysis, such as two-colour cross-correlation FCS and molecular brightness analysis, FCS provides the first opportunity to investigate the domain-specific nature of GPCR pharmacology.
AB0834-HPR Health-related physical fitness testing in physiotherapy practice – reference values
Authors: A. T. Tveter, T. Moseng, H. Dagfinrud, I. Holm
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> People with musculoskeletal conditions (MSCs) tend to be less physically active<sup>1</sup> and more deconditioned than healthy controls<sup>2</sup>. Recommendations for management of MSCs emphasize exercise as an important part of the treatment<sup>3.</sup> According to current recommendations, patients should be offered an individually tailored exercise program focusing on health-related physical fitness<sup>4</sup>. To improve the clinical usefulness of fitness-measures capturing the patients physical fitness, relevant reference values for these instruments are needed. <h3>Objectives</h3> The objective was to establish reference values and distribution of scores for frequently used measures of health-related physical fitness derived from age- and gender-groups of the general population. <h3>Methods</h3> In a cross-sectional study, 370 males and females 18-90 years of age were recruited. Five tests (6 min walk test, stair test, handgrip test, 30 sec sit-to-stand test and modified fingertip-to-floor test) and two questionnaires (Physical fitness questionnaire and COOP/WONCA) were included. <h3>Results</h3> Performance on all tests, except the modified fingertip-to-floor test, were stable until about 50 years of age, later performance was reduced with increasing age. Responses on patient-reported instrument were stable with gender and age. Distribution of scores are presented i Kernel plots. <h3>Image/graph</h3> <h3>Conclusions</h3> The reference values can improve the interpretability and clinical usefulness of fitness measures. <h3>References</h3> Farr et al. Physical activity levels in patients with early knee osteoarthritis measured by accelerometry. <i>Arthr Rheum</i> 2008; 59(9):1229-1236. Hodselmans et al. Nonspecific chronic low back pain patients are deconditioned and have an increased body fat percentage. <i>Int J Rehabil Res</i> 2010; 33(3):268-270. Hochberg et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. <i>Arthr Care Res</i> 2012; 64(4):465-474. Nelson et al. Physical activity and public health in older adults: recommendation from the ACSM and the AHA. <i>Med Sci Sports Exerc</i> 2007; 39(8):1435-1445 <h3>Disclosure of Interest</h3> None Declared
ADRENALINE AS A POTENTIAL FACTOR IN HYPERTHYROIDISM
Authors: D. J. Harries
Journal: BMJ (1923)

ADBNALINE IN' YPERTHYHOIDISE [ro-rrco Joct I 5The course of events is on retirospect fairly clear: the jugular bulb was probahly infected through the floor of the middle ear, the disease sparing the mastoid antrum and process.The result was a case very obscure right down to tle discovery of the perisinous abscess, which did not exceed a pea in volunle.I was niot free from anxiety for some days artfer the second operation.The cse well illustrates the uccessity for operating sometimes on very slight local ititications in the absence of other explanation of a severe inlfection.
Respiratory Arrest in near-Fatal Asthma
Authors: Nestor A. Molfino, Luis J. Nannini, Alberto N. Martelli, Arthur S. Slutsky
Journal: New England Journal of Medicine (1991)

The majority of asthma-related deaths occur outside the hospital, and therefore the exact factors leading to the terminal event are difficult to ascertain. To examine the mechanisms by which patients might die during acute exacerbations of asthma, we studied 10 such patients who arrived at the hospital in respiratory arrest or in whom it developed soon (within 20 minutes) after admission.
Addressing Physician Specialty Maldistribution
Authors: Howard K. Rabinowitz
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterisation of 17q12-21 – Identification of Novel Therapeutic Targets.
Authors: R. Glynn, N. Miller, E. Alvarez Iglesias, O. Doolin, J. Newell, M. Kerin
Journal: Cancer Research (2009)

Abstract Introduction: Over-expression of the HER2/neu oncogene is associated with poorer clinical outcome in breast cancer. Notwithstanding the success achieved with Trastuzumab in treating HER2/neu positive patients, numerous questions remain. In particular, there are concerns regarding accurate identification of HER2/neu positivity and the correct management of these patients in terms of the dosage, timing and optimal combination of Trastzumab with chemotherapeutic regimens. One approach to answering these questions has been to focus on the area of chromosome 17 in which HER2/neu is located in order to identify other genes in the vicinity. As potential therapeutic targets, we examined the amplification and expression patterns of co-localised cancer-associated genes at the HER2/neu amplicon on chromosome 17.Aims: The primary objective of this study was to examine amplification and expression patterns of co-localised genes at 17q12-21. In doing so, we aimed to establish their relationship with HER2/neu positivity, and then to quantify their relative importance in developing a gene panel predictive of HER2/neu status.Methods: Breast tissue from a cohort of patients with HER2/neu positive (n=48) and negative (n=48) tumours was retrieved at time of surgery. Protein and gene expression levels were determined using immunohistochemistry and RQ-PCR, respectively. Results were analysed to detect patterns of amplification among the genes, namely HER2/neu, STARD3, GRB7, TOP2A, TUBG1, RPL19, LASP1, RARA, and ER Alpha, and to identify associations between expression levels and clinical data. A binary logistic approach and classification tree analysis was employed to determine whether the expression levels of our target genes were useful predictors of HER2/neu status.Results: Strong correlation was noted between expression levels of HER2/neu and multiple cancer-associated genes at 17q12-21, including the novel genes LASP1 (p=0.000) and RPL19 (p=0.000). A significant relationship was also noted between TOP2A and the previously unexplored TUBG1 (p=0.000). Analysis of gene expression patterns according to clinicopathological variables revealed significant associations across intrinsic breast cancer subtypes.Conclusion: This study reaffirms the correlation between HER2/neu and its co-localised genes at 17q12-21, including novel candidate genes LASP1 and RPL19. We have also identified a novel relationship between TOP2A and TUBG1. Furthermore, our work represents a tentative step in the development of more accurate means of characterising HER2/neu status. As such, this work has again indicated the central role which this amplicon may play in selection of patients for treatment, not alone for Herceptin and anthracyclines, but also for taxane-based therapies, and as such, has revealed novel pathways for us to follow as we move towards our goal of individually tailored therapy. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3137.
PREVALENCE OF PULMONARY HYPERTENSION IN PATIENTS WITH END STAGE RENAL DISEASE AND ACUTE EFFECT OF HEMODIALYSIS ON RIGHT VENTRICULAR HEMODYNAMICS AND FUNCTION - PRELIMINARY ECHOCARDIOGRAPHIC FINDINGS FROM THE PROSPECTIVE PEPPER- STUDY
Authors: Christoph Hammerstingl, Stefan Pabst, Diana Momcilovic, Felix Hundt, Rainer Woitas, Dirk Skowasch
Journal: Journal of the American College of Cardiology (2011)