AN ANALYSIS OF THE PHENOMENON OF "ANTICIPATION" IN DIABETES MELLITUS
Authors: A G STEINBERG, R M WILDER
Journal: Annals of Internal Medicine (1952)

Article1 May 1952AN ANALYSIS OF THE PHENOMENON OF "ANTICIPATION" IN DIABETES MELLITUSARTHUR G. STEINBERG, Ph.D., RUSSELL M. WILDER, M.D., Ph.D., F.A.C.P.ARTHUR G. STEINBERG, Ph.D.Search for more papers by this author, RUSSELL M. WILDER, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the second edition of Darwin'sThe Variation of Animals and Plants Under Domestication,1published in 1894, it is stated that the rule with respect to the age of onset of a hereditary disease in parent and child is inheritance at a corresponding period of life. It was noted, however, that "when the rule fails the disease is apt to come on earlier in the child than in the parent; the exceptions in the other direction being very much rarer." Nevertheless, investigators were finding frequent exceptions to the rule for many different diseases with a variable age of onset; and...Bibliography1. Darwin CR: The variation of animals and plants under domestication, 2nd Ed., 1894, D. Appleton and Company, New York. Google Scholar2. Pieraccini A: Quoted by Pieraccini, A.,3 p. 555. Google Scholar3. Pieraccini A: On the priority of the biological hereditary law of "anticipation," Human Biol. 4: 554, 1932. Google Scholar4. Mott FW: Hereditary aspects of nervous and mental diseases, Brit. M. J. 2: 1013-1020 (Oct. 8) 1910. CrossrefMedlineGoogle Scholar5. WoodyattSpetz RTM: Anticipation in the inheritance of diabetes, J. A. M. A. 120: 602-605 (Oct. 24) 1942. CrossrefGoogle Scholar6. Penrose LS: The problem of anticipation in pedigrees of dystrophia myotonica, Ann. Eugenics 14: 125-132, 1948. CrossrefMedlineGoogle Scholar7. Goldschmidt R: "Progressive heredity" and "anticipation"; the possibility of a genetic explanation of certain odd hereditary phenomena observed in man, J. Hered. 29: 140-142 (Apr.) 1938. CrossrefGoogle Scholar8. Pearson K: On an apparent fallacy in the statistical treatment of "antedating" in the inheritance of pathological conditions, Nature, London 90: 334-335 (Nov. 21) 1912. CrossrefGoogle Scholar9. Heron D: An examination of some recent studies of the inheritance factor in insanity, Biometrika 10: 356-383 (Nov.) 1914. CrossrefGoogle Scholar10. Paterson AS: The socalled law of anticipation in mental disease, J. Neurol. and Psychopath. 13: 193-210 (Jan.) 1933. CrossrefMedlineGoogle Scholar11. SteinbergWilder AGRM: A reconsideration of the phenomenon of anticipation of diabetes mellitus, Proc. Staff Meet., Mayo Clin. 25: 625-630 (Nov. 8) 1950. MedlineGoogle Scholar12. JoslinRootWhiteMarbleBailey EPHFPACC: The treatment of diabetes mellitus, 8th Ed., 1946, Lea & Febiger, Philadelphia. Google Scholar13. Harris H: The familial distribution of diabetes mellitus: A study of the relatives of 1241 diabetic propositi, Ann. Eugenics 15: 95-119 (Mar.) 1950. CrossrefMedlineGoogle Scholar14. MillerHurwitzKuder HCDK: Fetal and neonatal mortality in pregnancies complicated by diabetes mellitus, J. A. M. A. 124: 271-275 (Jan. 29) 1944. CrossrefGoogle Scholar15. BarnsMorgans HHME: Prediabetic pregnancy, J. Obst. and Gynaec. Brit. Emp. 55: 449-454 (Aug.) 1948. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication October 1, 1951.From the Division of Biometry and Medical Statistics and the Division of Medicine, Mayo Clinic, Rochester, Minnesota.†Emeritus member, Division of Medicine, Mayo Clinic; now director, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U. S. Public Health Service, Federal Security Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLMNA -associated partial lipodystrophy: anticipation of metabolic complicationsSulla Genetica del Diabete Analisi di nove casi famigliariHeredity in Diabetes MellitusMedicina preventiva del diabete mellito: Compiti, possibilita' e limitiChronon and the Problem of Anticipation (On two family cases of diabetes)Il problema dell'eredita' del diabeteFamilial Occurrence of Regional Enteritis and Ulcerative ColitisTHE GENETICS OF DIABETES: A REVIEW*Zur Genetik des Diabetes mellitusHeredity and diabetes 1 May 1952Volume 36, Issue 5Page: 1285-1296KeywordsArthritisDiabetes mellitusGenetic diseasesGratitudeMedical servicesMetabolic disordersPrevention, policy, and public health Issue Published: 1 May 1952 PDF DownloadLoading ...