tbuckley/cabot-search huggingface dataset:
Cardiovascular Aspects of the Ehlers-Danlos Syndrome
Authors: PIERRE BOPP, KASSEM HATAM, PHILIPPE BUSSAT, GEORGES GREDER, PIERRE W. DUCHOSAL
Journal: Circulation (1965)

The case of a 10--year-old boy is reported because of the association of the Ehlers-Danlos syndrome with bifidity of the pulmonary artery and anomaly of the aortic arch. The cardiovascular aspects of this connective-tissue disorder are reviewed, and the possibility of another common feature with the Marfan syndrome is briefly discussed.
On Paralytic Chorea
Authors: W. R. Gowers
Journal: BMJ (1881)

S1Lincreases the appetite and the power of assimilation, it has no influence in increasing the richness of the blood in h~emoglobia (Moriez).Lastly, quinine and strychnine, although not homatinics in the strict sense of the word, are very valuable as adjuvants; and the same may be said of the mineral acids and bitters.The Subject of transfusion of blood is one which demands the most thoroti-lh examination in reference to the treatment of anaemia.In sonic forms of symptomatic anaemia, especially when the cause is a sudden loss of blood, there can be no question either as to the propriety of transfusion or its efficacy in saving life.It is another matter, how cver, when we have to deal with the insidious and progressive anxiiiia, which has been denoted by the term "pernicious'.Trans.fuiiri has not yet been employed to a very large extent in such cases,and it has often failed of success.I find that it was performed in 20 out of I 10 cases, to which I referred in my last lecture, and that the six recoveries (one of which was not permanent) all occurred in Quiticke's practice.I think his success in these cases may be attributed to his having re- sorted to transfusion at a less advanced stage of the disease than is usually the case.His first cases were invariably fatal, and in his comnientary upon them he pointed out the inutility of deferring transfusion until the heart is already advanced in degeneration, and restoration is well nigh hopeless.In one of his papers, where he summarises the res.dts of five such transfusions, he says that defibrinated human blood was used, and from So to ioo cubic centimrntres injected into the radial artery.(Professor Schafer, in his valuable report to the Obstetrical Society of last year, advocates immediate injection from artery to artery as far preferable to intravenous injection, whether mediate or imiiiediate.It will be seen that Quincke performs an operation the
Comparison of height, weight and BMI of Indian school children (6-14 years of age) with WHO New Growth Standards
Authors: Meenu Dhingra, Rita Jain, Yujwal Raj
Journal: British Journal of Sports Medicine (2010)

Background WHO New Growth Standards 2006 are considered appropriate for Indian population and clinicians and anthropologists can assess nutritional status of children much early in life. Comparing with these standards provide useful insights into early recognition and prevention of childhood nutritional problems. Objective and methodology With the objective of assessing the nutritional status of school children, an anthropometric survey of Delhi school children (N=711) aged 6–14 years (boys=398; girls= 313) was conducted in 2008. Height, weight and body mass index were compared with WHO New Growth Standards 2006. Statistical analysis was based on WHO Anthroplus software for calculation of mean, median, SD, range and z scores, for each variable over 9 age groups in boys and girls. Results Results of z scores for weight-for-age (zwfa), height-for-age (zhfa) and BMI-for-age (zbfa) indicate that boys fall in the overweight category with shorter height (SD &gt;1&lt;2) in all age groups except at age group 8 where the boys are significantly taller than reference values. In case of girls, zwfa and zbfa indicate that girls are overweight in all age groups (SD &gt;1&lt;2) except at age 6 and zhfa scores reflect that they are shorter than the reference values across all age groups. Conclusions The present study shows overweight condition of both boys and girls in the study of Indian school. Nutritional intervention and physical activity programme may be suggested to them to prevent any further complications. It is recommended that similar study be carried out every year on school children to monitor the progress of growth and development.
Differentiation of rat bone marrow cells cultured on artificial basement membrane containing extracellular matrix into a liver cell lineage
Authors: Kazuo Okumoto, Takafumi Saito, Etsuko Hattori, Jun-itsu Ito, Akihiko Suzuki, Keiko Misawa, Rika Ishii, Tetsuru Karasawa, Hiroaki Haga, Mai Sanjo, Tadashi Takeda, Kazuhiko Sugahara, Koji Saito, Hitoshi Togashi, Sumio Kawata
Journal: Journal of Hepatology (2005)
Platelet-Activating Factor Acetylhydrolase Prevents Myocardial Ischemia-Reperfusion Injury
Authors: E. N. Morgan, E. M. Boyle, W. Yun, J. C. Kovacich, T. G. Canty, E. Chi, T. H. Pohlman, E. D. Verrier
Journal: Circulation (1999)

Platelet-activating factor (PAF) is one of the most potent biological mediators of tissue injury. PAF acetylhydrolase (PAF-AH) is a recently isolated naturally occurring enzyme that hydrolyzes PAF and renders it inactive. We hypothesize that inhibition of PAF with PAF-AH will reduce myocardial ischemia-reperfusion (I/R) injury in vivo.The coronary ligation model was used in New Zealand white rabbits. The large branch of the marginal coronary artery was occluded for 45 minutes, followed by 2 hours of reperfusion. Fifteen minutes before reperfusion, animals were given either 2 mg/kg of vehicle or of PAF-AH. At the completion of 120 minutes of reperfusion, percentage of necrosis, degree of neutrophil infiltration, and measurements of regional contractility were assessed. Data are expressed as the mean+/-SEM and compared by Student's t test or Mann-Whitney ANOVA. Both groups of animals showed an equivalent area at risk; however, 46.7+/-11% was necrotic in the animal treated with vehicle. In contrast, 20.9+/-7.0% was necrotic in the animals treated with PAF-AH (P<0.05). Systolic shortening and wall thickness were significantly greater in those animals treated with PAF-AH at 15, 30, 60, and 120 minutes of reperfusion (P<0.05). Quantification of neutrophil infiltration showed a 62% reduction in the PAF-AH treated animals compared with those treated with vehicle alone.PAF-AH is a potent cardioprotective agent in an in vivo model of I/R injury.
Responder Analysis of AQLQ in the Asthma Intervention Research (AIR) Trial
Authors: R.M. Niven, G. Cox, J.D. Miller, M. Laviolette, A.S. Rubin, P.A. Corris, H.C. Siersted, R. Olivenstein, D. McCormack, I.D. Pavord
Journal: Journal of Allergy and Clinical Immunology (2009)
The obsessive pursuit of health and happiness
Authors: D. Greaves
Journal: BMJ (2000)

Manic depression is part of my life, and as I have suffered both the agony of manic episodes and the despair of depressive ones, the thought of obtaining lasting happiness has a recurring appeal. Yet deep down I know this appeal to be false.

Richard Bentall once proposed that happiness be classified as a mental disorder,1 but only as a device to parody psychiatric orthodoxy, and so did not intend it to be taken literally. He may have stumbled unwittingly, …
KDR/Flk-1 is a major regulator of vascular endothelial growth factor-induced tumor development and angiogenesis in murine hepatocellular carcinoma cells
Authors: Hitoshi Yoshiji, Shigeki Kuriyama, Daniel J. Hicklin, James Huber, Junichi Yoshii, Yoji Miyamoto, Mitsuhiro Kawata, Yasuhide Ikenaka, Toshiya Nakatani, Hirohisa Tsujinoue, Hiroshi Fukui
Journal: Hepatology (1999)

Vascular endothelial growth factor (VEGF), which is one of the most potent angiogenic factors, has been shown to play a pivotal role in tumor angiogenesis, including hepatocellular carcinoma (HCC). The effects of VEGF are mediated mainly through two distinct receptors, flt-1 and KDR/Flk-1. It has been suggested that KDR/Flk-1 plays an important role in tumor development. However, the role of KDR/Flk-1 in HCC has not been examined. We previously reported that VEGF tightly regulated murine HCC development, based on the results of a study using a retroviral tetracycline-regulated (Retro-Tet) gene expression system. This system allows VEGF gene expression to be manipulated in vivo by providing tetracycline in the drinking water. In the present study, we combined the KDR/Flk-1-specific neutralizing monoclonal antibody (KDR/Flk-1mAb) and the Retro-Tet system to elucidate the role of KDR/Flk-1 in VEGF-induced tumor development and angiogenesis in a murine HCC experimental model. In a xenograft study, tumor augmentation induced by VEGF overexpression was almost abolished by means of KDR/Flk-1mAb treatment, with accompanying inhibition of angiogenesis, KDR/Flk-1 autophosphorylation, but not interference of flt-1 activation. This inhibitory effect was achieved even on established tumors and regardless of whether the tumor size was small or large. On the contrary, KDR/Flk-1mAb treatment significantly increased the apoptosis in the tumor. With orthotopic transplantation, KDR/Flk-1mAb also inhibited HCC development in the liver. These results suggest that KDR/Flk-1 is a major regulator of VEGF-mediated HCC development and angiogenesis not only at the initial stage, but also after the tumor has fully developed.
Chronic Hepatic Artery Infusion Therapy of Primary and Metastatic Hepatic Malignancies.
Authors: Melvin L. Reed
Journal: Annals of Internal Medicine (1969)

s1 May 1969Chronic Hepatic Artery Infusion Therapy of Primary and Metastatic Hepatic Malignancies.Melvin L. Reed, M.D., V. K. Vaitkevicius, M.D., F.A.C.P., Clarence B. Vaughn, M.D.Melvin L. Reed, M.D.Search for more papers by this author, V. K. Vaitkevicius, M.D., F.A.C.P.Search for more papers by this author, Clarence B. Vaughn, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1106_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSystemic 5-fluorouracil (5-FU) therapy of gastroitestinal tumors produces objective tumor remissions in 12 to 20% of patients. Drug toxicity prevents administration of sufficient amounts of 5-FU to induce higher regression rates. With tuomrs limited to the liver, systemic therapy can be avoided. The liver receives a double blood supply, approximately 90 to 95% from the portal vein and 5 to 10% from the hepatic artery. Primary or metastatic tumor in the liver receives approximately 5 to 10% from the portal vein and 90 to 95% from the hepatic artery. Infusion of cytotoxic drugs directly into the hepatic artery delivers all... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Melvin L. Reed, M.D.; V. K. Vaitkevicius, M.D., F.A.C.P.; Clarence B. Vaughn, M.D.Affiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1106-1106KeywordsAdverse reactionsArteriesBloodDrug administrationDrugsGastroenterology and hepatologyLiverMetastatic tumorsPortal veins ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
The Use of Periareolar Intradermal Tc-99m Tin Colloid and Peritumoral Intraparenchymal Isosulfan Blue Dye Injections for Determination of the Sentinel Lymph Node
Authors: Aziz Murat Argon, Ulkem Duygun, Ebru Acar, Gozde Daglioz, Levent Yenjay, Ozman Zekioglu, Murat Kapkac
Journal: Clinical Nuclear Medicine (2006)

The purpose of the present study was to evaluate the use of lymphoscintigraphy, blue dye, and gamma probe detection methods for determination of the sentinel lymph node (SLN) using both periareolar intradermal injection of Tc-99m tin colloid and peritumoral intraparenchymal injection of isosulfan blue dye.One hundred patients with T1-2 breast cancer and clinically negative nodes were enrolled in the present study. The study was composed of 2 groups. Backup axillary lymph node dissection (ALND) was mandatory in group 1 (20 patients) regardless of their lymph node status. In group 2 (80 patients), complete ALND was performed when intraoperative frozen section analysis of SLN revealed metastases. Otherwise, only SLN biopsy was performed without ALND. One day before surgery, Tc-99m tin colloid was injected at 4 periareolar sites intradermally. Lymphoscintigraphy was performed 1 to 2 hours after injection of the radiocolloid. Twenty minutes before surgery, isosulfan blue dye was injected into parenchyma surrounding the tumor or the biopsy cavity.The detection rates of SLN and false-negative rate of lymphoscintigraphy, blue dye, and gamma probe detection were 85%, 95% 100%, and 0% in group 1, 91%, 87%, and 95% in group 2, respectively. Detection rate by the combination of blue dye and radio tracer was 98%.According to the results of our study, we conclude that perioareolar intradermal injection of Tc-99m tin colloid combined with peritumoral intraparenchymal injection of blue dye is an accurate and easy method of locating the sentinel node with very high detection rates. It is recommended that the combination of all methods such as lymphoscintigraphy, blue dye, and gamma probe application will increase the success rate of SLN detection in patients with breast cancer.
Normal-Pressure Hydrocephalus
Authors: L. P. Hinterbuchner
Journal: JAMA (1990)

<h3>To the Editor.—</h3> I enjoyed the article about normal-pressure hydrocephalus by Dr Friedland<sup>1</sup>and the editorial comments by Dr Clarfield.<sup>2</sup>While the term "treatable dementia" is fine, all of us who have been in the practice of neurology long enough will remember many failures of shunt procedures to balance each success. Given the pitfalls of diagnosis and especially the difficulty of selecting the most suitable patients for shunt procedures, it is curious that Drs Friedland and Clarfield omitted any mention of a scinticisternogram. Either a positive or a negative comment would have been useful. If negative, the potential candidates for shunt could be spared a spinal tap and the operator could avoid exposure to radioisotopes. If positive, surely the information could be confirmatory to the diagnosis or at least linked to eventual beneficial outcome?
The IL-8, VEGF, and CFH Polymorphisms and Bevacizumab in Age-related Macular Degeneration
Authors: Asta Hautamäki, Jarno Kivioja, Sanna Seitsonen, Eeva-Riitta Savolainen, M. Johanna Liinamaa, Arto Luoma, Irma Järvelä, Ilkka Immonen
Journal: Ophthalmology (2014)
Nutritional Assessment
Authors: Jeffrey P. Baker, Allan S. Detsky, David E. Wesson, Stephen L. Wolman, Sandra Stewart, Jocelyn Whitewell, Bernard Langer, Khursheed N. Jeejeebhoy
Journal: New England Journal of Medicine (1982)

THE diagnosis of protein-calorie malnutrition is often based on objective measurements of nutritional status,1 including assessments of hepatic secretory proteins (serum albumin and serum transferrin), anthropometric evaluation, creatinine-height index, and determination of cell-mediated immunity. Although these indicators are epidemiologically useful and correlate with morbidity and mortality,2 3 4 5 6 no single measurement is of consistent value in individual patients.nutritional status may also be assessed by clinical examination. Although this method is used routinely, its validity and reproducibility do not appear to have been tested.To determine the reproducibility and validity of clinical assessment of nutritional status, we studied the nutritional status of . . .
PRELIMINARY INVESTIGATIONS OF ARTERITIC LESIONS USING FLUORESCENT ANTIBODY TECHNIQUES.*
Authors: D. G. SCOTT, N. R. ROWELL
Journal: British Journal of Dermatology (1965)

Journal Article PRELIMINARY INVESTIGATIONS OF ARTERITIC LESIONS USING FLUORESCENT ANTIBODY TECHNIQUES. Get access D. G. SCOTT, D. G. SCOTT Department of Dermatology University of Leeds Search for other works by this author on: Oxford Academic Google Scholar N. R. ROWELL N. R. ROWELL Department of Dermatology University of Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 4, 1 April 1965, Pages 211–220, https://doi.org/10.1111/j.1365-2133.1965.tb14633.x Published: 01 April 1965
Tridimensional Personality Questionnaire Factors in Major Depressive Disorder: Relationship to Anxiety Disorder Comorbidity and Age of Onset
Authors: Dost Öngür, Amy Farabaugh, Dan V. Iosifescu, Roy Perlis, Maurizio Fava
Journal: Psychotherapy and Psychosomatics (2005)

&lt;i&gt;Objective:&lt;/i&gt; We used the Tridimensional Personality Questionnaire (TPQ) to study the relationship between temperamental traits and comorbid anxiety disorders as well as age of onset of major depressive disorder (MDD) in 263 patients with MDD. &lt;i&gt;Methods:&lt;/i&gt; Patients recruited for a large clinical study on MDD underwent a Structured Clinical Interview for DSM-III-R assessment and were administered the self-rated TPQ [mean age = 39.5 ± 10.5 years, women = 138 (53%), initial 17-item Hamilton Rating Scale for Depression (HAM-D-17) score = 19.6 ± 3.4]. The TPQ was scored for three previously identified factors – harm avoidance (HA), novelty seeking (NS), and reward dependence (RD). Multiple linear regression methods were used to evaluate the relationship between TPQ factors and each comorbid anxiety disorder as well as between early- vs. late-onset MDD, after controlling for age, gender and initial HAM-D-17 score (when these were related to the dependent variable in simple regressions). &lt;i&gt;Results:&lt;/i&gt; Social anxiety disorder in MDD was strongly associated with higher scores on HA and lower scores on NS and RD (t = 5.4, p &lt; 0.0001; t = 2.6, p = 0.009; t = 2.2, p = 0.028, respectively). A diagnosis of generalized anxiety disorder in MDD was significantly related to higher HA scores (t = 2.8, p = 0.006). The presence of comorbid obsessive-compulsive disorder was associated with lower NS scores (t = 2.3, p = 0.023) as was that of comorbid panic disorder (t = 2.0, p = 0.051). Finally, the presence of simple phobias was associated with lower scores on RD (t = 2.4, p = 0.016). HA scores were higher in patients with early onset of MDD (adjusted p = 0.05). Early versus late onset of MDD was not significantly related to NS or RD scores. &lt;i&gt;Limitations:&lt;/i&gt; Since our sample consisted of moderately depressed outpatients, our ability to generalize our findings to other populations is limited. &lt;i&gt;Conclusions:&lt;/i&gt; Features of temperament are related to patterns of anxiety disorder comorbidity and age of onset among patients with MDD. Higher levels of HA and lower levels of RD and NS were associated with an increased risk of anxiety disorder comorbidity in our sample. HA may also be related to early onset of depression.
Molecular characterization of the recurrent unbalanced translocation der(1;7)(q10;p10)
Authors: Lili Wang, Seishi Ogawa, Akira Hangaishi, Ying Qiao, Noriko Hosoya, Yasuhito Nanya, Kazuma Ohyashiki, Hideaki Mizoguchi, Hisamaru Hirai
Journal: Blood (2003)
Hydraulic Mechanisms in Endocarditis.
Authors: S. Rodbard
Journal: Annals of Internal Medicine (1961)

s1 May 1961Hydraulic Mechanisms in Endocarditis.S. Rodbard, M.D., F.A.C.P.S. Rodbard, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1039_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnalyses of pathologic findings in infective endocarditis, as well as of hydraulic and bacteriologic studies, suggest that this process occurs only at sites where high pressure gradients extrude blood at high velocities through narrow orifices. Thus, involvement occurs only on the ventricular surfaces of insufficient aortic valves, on the atrial surfaces in mitral insufficiency, and beyond the narrowings of coarctations and of arteriovenous fistulae. Initial vascular injury is not a prerequisite. Endocarditis never occurs at large openings, such as atrial septal defects or a widely patent ductus, since the pressure gradient is not present and high velocities do not occur.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntroduction to medical electronicsDeposition of Flowborne Materials on Vessel WallsPatent Ductus Arteriosus with Reversal of Flow in AdultsFRANK H. DAILEY, M.D., PASQUALE D. GENOVESE, M.D., F.A.C.P., ROY H. BEHNKE, M.D. 1 May 1961Volume 54, Issue 5Page: 1039-1039KeywordsAortic valveAtrial septal defectEndocarditisMitral insufficiencyPrimary hypertension ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Use of the Prostate Imaging Reporting and Data System (PI-RADS) for Prostate Cancer Detection with Multiparametric Magnetic Resonance Imaging: A Diagnostic Meta-analysis
Authors: Esther H.J. Hamoen, Maarten de Rooij, J. Alfred Witjes, Jelle O. Barentsz, Maroeska M. Rovers
Journal: European Urology (2014)
The Seco-Taxane IDN5390 Is Able to Target Class III β-Tubulin and to Overcome Paclitaxel Resistance
Authors: Cristiano Ferlini, Giuseppina Raspaglio, Simona Mozzetti, Lucia Cicchillitti, Flavia Filippetti, Daniela Gallo, Caterina Fattorusso, Giuseppe Campiani, Giovanni Scambia
Journal: Cancer Research (2005)

Abstract A prominent mechanism of drug resistance to taxanes is the overexpression of class III β-tubulin. The seco-taxane IDN5390 was chosen for its selective activity in paclitaxel-resistant cells with an overexpression of class III β-tubulin. Moreover, the combined treatment paclitaxel/IDN5390 yielded a strong synergism, which was also evident in cell-free tubulin polymerization assays. In the presence of an anti-class III β-tubulin as a blocking antibody, tubulin polymerization induced by paclitaxel and IDN5390 was enhanced and not affected, respectively, whereas synergism was abolished, thereby indicating that IDN5390 activity is not modulated by class III β-tubulin levels. Such properties can be explained by taking into consideration the composition of class III β-tubulin paclitaxel binding site; in fact, Ser277 interacting with paclitaxel C group in class I is replaced by an Arginine in class III. IDN5390 that has an open and flexible C ring and an acidic α-unsaturated enol-keton moiety better fits with class III β-tubulin than paclitaxel at the binding site. Taking altogether, these findings indicate that the concomitant treatment IDN5390/paclitaxel is able to successfully target class I and III β-tubulin and the combined use of two taxanes with diverse spectrum activity against tubulin isotypes could represent a novel approach to overcome paclitaxel resistance.
Unusual fatal brain injury due to knitting-needle.
Authors: E. E. Payne
Journal: BMJ (1966)

Idoxuridine-MacCallum and 7uel-fensen aEDICJOHURNAL 807 solution described above.The amount of herpes virus recovered in successive cultures decreased more rapidly and the virus dis- appeared more quickly than in previous patients who had had no idoxuridine. SummaryPatients with 21 attacks of herpes of the face participated in a double-blind controlled trial to test the effect of idoxuridine in the form of a 5% solution in dimethyl sulphoxide.The solution was applied with a paintbrush three times a day for three days; a total volume of 1 ml.was used.In 10 patients receiving the idoxuridine solution there was an average shorten- ing of the expected duration of the lesion of 6.3 days (or 63 %) and an average shortening of two days compared with those treated with dimethyl sulphoxide alone.This was the greatest reduction achieved so far.The results indicate that it should be possible to obtain a suitable preparation of idoxuridine which will be of therapeutic value in those in whom recurrent attacks of herpes simplex virus skin infection usually persist for seven days or longer.Our thanks are due to Dr. T. A. Turnbull, of Smith Kline and French Laboratories Ltd., for the supply of idoxuridine; to Mr. Ivor Chin, F.I.M.L