tbuckley/cabot-search huggingface dataset:
Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial
Authors: Paolo Prandoni, Franco Noventa, Roberto Quintavalla, Carlo Bova, Benilde Cosmi, Sergio Siragusa, Eugenio Bucherini, Francesco Astorri, Stefano Cuppini, Fabio Dalla Valle, Anthonie W. A. Lensing, Martin H. Prins, Sabina Villalta
Journal: Blood (2011)
NICE needs to move faster to keep up with NHS changes
Authors: M. Limb
Journal: BMJ (2012)

Health and social care experts are asking the UK National Institute for Health and Clinical Excellence (NICE) to produce guidance more quickly as it expands its role. They also want more to be done to measure the effect of new quality standards on the care of patients.

At a London seminar hosted by the Westminster Health Forum on 26 January, expert panellists and an audience from a range of sectors debated issues raised by NICE’s proposed new role, including how to ensure implementation of standards.

NICE is due to become a non-departmental public body in April 2013, and its role in social care is …
Rehabilitation on a General Medical Ward
Authors: Harold N. Willard, Homer Wick, John Pemberton, Hortense Darling
Journal: New England Journal of Medicine (1958)

THERE is a growing body of literature calling for a broader approach to patient care. This approach is referred to as preventive medicine, social medicine, rehabilitation or comprehensive medical care. As defined by the National Foundation for Infantile Paralysis, "rehabilitation is the process of assisting the individual with a handicap to realize his potentials and goals, physically, mentally, socially, and economically."The purpose of this study is to determine if there is actually a need on a general medical ward for treatment that focuses on rehabilitation rather than limiting itself to diagnoses.The medical literature on this subject is limited. . . .
La relation psychothérapique avec le délinquant
Authors: P. Moutin, E. Dervaux
Journal: Psychotherapy and Psychosomatics (1972)

The authors examine the specific problems of delinquents' psychotherapy, from the psychoanalytic and phenomenological point of view. The most difficult problem which the psychiatrist comes up against is to induce the delinquent to undertake himself to a relation which is generally felt as a threat against his narcissism. The purpose of the treatment is to increase his possibilities of choice. Moreover, the ambiguity of the psychotherapist's position, more connected to the penal process, must be plainly grasped by himself, to avoid directing the relation on the criminal acts rather than on the delinquent's personality, in a too limited prospect of social readaptation.
Multiple Localized Neurofibromas
Authors: Raymond L. Garcia
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Neurofibromas are nonencapsulated benign tumors derived from peripheral nerves and their supporting structures. They are usually multiple and extensive, and occur as part of the von Recklinghausen's neurofibromatosis syndrome. Solitary neurofibromas are probably developmental malformations or hamartomas which are presently classified as neural nevi. Occasionally multiple neurofibromas are limited to a small area and are then referred to as localized neurofibromas. Neither of the later lesions has been associated with von Recklinghausen's disease. The following case report is illustrative of localized neurofibromas. <h3>Report of a Case.—</h3> A 72-year-old man presented with a localized cluster of firm, slightly pedunculated, brownish papules of his right anticubital fossa. These lesions were first noted by<i>the patient approximately 30 years</i>earlier, increasing in number and size during the following ten years and remaining indolent and asymptomatic thereafter. There were no café au lait spots or axillary freckling. There were no symptoms
Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION)
Authors: Elias Jabbour, Hagop M. Kantarjian, Giuseppe Saglio, Juan Luis Steegmann, Neil P. Shah, Concepción Boqué, Charles Chuah, Carolina Pavlovsky, Jiří Mayer, Jorge Cortes, Michele Baccarani, Dong-Wook Kim, M. Brigid Bradley-Garelik, Hesham Mohamed, Mark Wildgust, Andreas Hochhaus
Journal: Blood (2013)
ARTERIAL AND VENOUS ENDOTHELIAL DYSFUNCTION IN RESISTANT HYPERTENSIVE PATIENTS
Authors: Juan Carlos Yugar-Toledo, Leoni A. Souza, Samira U. Girioli, Luiz C. Martins, Leandro B. Martins, José F. Vilela-Martin, Cláudia M. Irigoyen, Heitor Moreno
Journal: Journal of the American College of Cardiology (2010)
Lactation Intensity and Postpartum Maternal Glucose Tolerance and Insulin Resistance in Women With Recent GDM
Authors: Erica P. Gunderson, Monique M. Hedderson, Vicky Chiang, Yvonne Crites, David Walton, Robert A. Azevedo, Gary Fox, Cathie Elmasian, Stephen Young, Nora Salvador, Michael Lum, Charles P. Quesenberry, Joan C. Lo, Barbara Sternfeld, Assiamira Ferrara, Joseph V. Selby
Journal: Diabetes Care (2011)

OBJECTIVE To examine the association between breastfeeding intensity in relation to maternal blood glucose and insulin and glucose intolerance based on the postpartum 2-h 75-g oral glucose tolerance test (OGTT) results at 6–9 weeks after a pregnancy with gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS We selected 522 participants enrolled into the Study of Women, Infant Feeding, and Type 2 Diabetes (SWIFT), a prospective observational cohort study of Kaiser Permanente Northern California members diagnosed with GDM using the 3-h 100-g OGTT by the Carpenter and Coustan criteria. Women were classified as normal, prediabetes, or diabetes according to American Diabetes Association criteria based on the postpartum 2-h 75-g OGTT results. RESULTS Compared with exclusive or mostly formula feeding (&amp;gt;17 oz formula per 24 h), exclusive breastfeeding and mostly breastfeeding (≤6 oz formula per 24 h) groups, respectively, had lower adjusted mean (95% CI) group differences in fasting plasma glucose (mg/dL) of −4.3 (−7.4 to −1.3) and −5.0 (−8.5 to −1.4), in fasting insulin (μU/mL) of −6.3 (−10.1 to −2.4) and −7.5 (−11.9 to −3.0), and in 2-h insulin of −21.4 (−41.0 to −1.7) and −36.5 (−59.3 to −13.7) (all P &amp;lt; 0.05). Exclusive or mostly breastfeeding groups had lower prevalence of diabetes or prediabetes (P = 0.02). CONCLUSIONS Higher intensity of lactation was associated with improved fasting glucose and lower insulin levels at 6–9 weeks’ postpartum. Lactation may have favorable effects on glucose metabolism and insulin sensitivity that may reduce diabetes risk after GDM pregnancy.
Moderate-Intensity Physical Activity Ameliorates the Breast Cancer Risk in Diabetic Women
Authors: Gabriela Torres-Mejía, Angélica Angeles-Llerenas, Carolina Ortega-Olvera, Eduardo Lazcano-Ponce, Elad Ziv, José Pulido-Rodríguez, Manuel de Jesús García-Solis, Efrén Murillo-Zamora, Julia Vázquez-Lara, Isabelle Romieu
Journal: Diabetes Care (2012)

OBJECTIVE To evaluate the association between self-reported diabetes and the risk of breast cancer (BC) and its interaction with moderate-intensity physical activity in pre- and postmenopausal Mexican women. RESEARCH DESIGN AND METHODS A population-based case-control study was conducted using 1,000 incident case subjects and 1,074 control subjects. Blood samples and information on health, diet, physical activity, and anthropometric measurements were obtained. RESULTS The association between diabetes and BC risk decreased with increasing tertiles of moderate-intensity physical activity (odds ratio [OR] = 4.9 [95% CI 2.3–10.8]; 3.0 [1.3–6.9]; and 1.0 [0.1–9.2], respectively, for each tertile) (test for interaction = 0.04). Compared with the women in the lowest tertiles, increased risk was observed in those premenopausal women with the highest serum C-peptide, IGF-1, and IGF-1 binding protein 3 levels. CONCLUSIONS Moderate-intensity physical activity can substantially ameliorate the increased BC risk in diabetic women.
Organization of Myocardial Activation During Ventricular Fibrillation After Myocardial Infarction
Authors: Stuart P. Thomas, Aravinda Thiagalingam, Elisabeth Wallace, Pramesh Kovoor, David L. Ross
Journal: Circulation (2005)

Studies of ventricular fibrillation (VF) in small mammals have revealed localized sustained stationary reentry. However, studies in large mammals with surface mapping techniques have demonstrated only relatively short-lived rotors. The purpose of this study was to identify whether sustained high-frequency activation with low beat-to-beat variability was present at intramural sites in a postinfarct ovine model of VF.VF was induced in 12 sheep 77+/-40 days after anterior myocardial infarction. Electrical activation was recorded with 20 multielectrode transmural plunge needles. Unipolar electrogram frequency content and local cycle duration variability were studied in 30-second recordings beginning 5 seconds after the onset of VF. Higher mean beat frequency was associated with lower SD of the cycle duration intervals (r=-0.91, P<0.001). The mean beat frequency and the SD of cycle duration intervals of the highest-frequency electrode were 8.8+/-2.0 Hz and 17+/-11 ms. In 3 cases, a region with regular activation throughout the recording was identified (SD of the cycle duration interval, 6.0+/-0.7 ms). Two of these sites and 67% of all sites with low local cycle duration variability were intramural. They occurred within regions with a high dominant frequency as determined by fast Fourier transform of the unipolar electrogram.Regions with the highest frequency of activation during VF were always associated with a low local cycle duration variability and usually intramural in this chronic infarct model. In a minority of cases, a region of stable, rapid, and very regular activation could be identified. These findings support the hypothesis that relatively stable periodic sources form a component of the mechanism of VF in this model.
Platelet Activation and Atherothrombosis
Authors: Giovanni Davì, Carlo Patrono
Journal: New England Journal of Medicine (2007)

This review of the role of platelets in atherothrombosis illuminates the surprisingly numerous activities of these tiny, anucleate cells and stresses their participation in the inflammatory component of atherothrombosis. The information is presented in the context of the prevention of atherothrombosis by antiplatelet agents now in clinical use.
Pediatric Cancer Survivorship Research: Experience of the Childhood Cancer Survivor Study
Authors: Wendy M. Leisenring, Ann C. Mertens, Gregory T. Armstrong, Marilyn A. Stovall, Joseph P. Neglia, Jennifer Q. Lanctot, John D. Boice, John A. Whitton, Yutaka Yasui
Journal: Journal of Clinical Oncology (2009)

The Childhood Cancer Survivor Study (CCSS) is a comprehensive multicenter study designed to quantify and better understand the effects of pediatric cancer and its treatment on later health, including behavioral and sociodemographic outcomes. The CCSS investigators have published more than 100 articles in the scientific literature related to the study. As with any large cohort study, high standards for methodologic approaches are imperative for valid and generalizable results. In this article we describe methodological issues of study design, exposure assessment, outcome validation, and statistical analysis. METHODS for handling missing data, intrafamily correlation, and competing risks analysis are addressed; each with particular relevance to pediatric cancer survivorship research. Our goal in this article is to provide a resource and reference for other researchers working in the area of long-term cancer survivorship.
AMERICAN MEDICAL SOCIETY IN VIENNA
Authors: M. Arthur Kline
Journal: JAMA (1953)

<h3>To the Editor:</h3> —On or about May 1, we are scheduled to open our new American Medical Society club rooms, situated on Universitätsstrasse 11, adjacent to the university and clinics. These new quarters are larger and more representative than the old premises, which were closed by Nazi decree in 1941. In the years between 1904 and 1941, over 20,000 English speaking postgraduates enjoyed the facilities and amenities provided within the former A. M. A. of Vienna club quarters. During that time members enjoyed a comfortable and adequate library, which contained most of the then recent medical volumes and periodicals. The new club rooms have been designed with very special attention to the library. Space for over 4,000 books has been provided. Unfortunately, but very few rather outdated books are presently available. Many thousands of former A. M. A. "life-members" will surely remember the hours they spent in the old library
932 A FREQUENT PNPLA3 VARIANT IS A SEX SPECIFIC DISEASE MODIFIER IN PSC PATIENTS WITH BILE DUCT STENOSIS
Authors: K. Friedrich, C. Rupp, J.R. Hov, K.-H. Weiss, P. Schirmacher, T.H. Karlssen, W. Stremmel, D.N. Gotthardt
Journal: Journal of Hepatology (2013)
Right Ventricular Systolic Function in Organic Mitral Regurgitation
Authors: Thierry Le Tourneau, Guillaume Deswarte, Nicolas Lamblin, Claude Foucher-Hossein, Georges Fayad, Marjorie Richardson, Anne-Sophie Polge, Claire Vannesson, Yan Topilsky, Francis Juthier, Jean-Noel Trochu, Maurice Enriquez-Sarano, Christophe Bauters
Journal: Circulation (2013)

To assess the prevalence, determinants, and prognosis value of right ventricular (RV) ejection fraction (EF) impairment in organic mitral regurgitation.Two hundred eight patients (62±12 years, 138 males) with chronic organic mitral regurgitation referred to surgery underwent an echocardiography and biventricular radionuclide angiography with regional function assessment. Mean RV EF was 40.4±10.2%, ranging from 10% to 65%. RV EF was severely impaired (≤35%) in 63 patients (30%), and biventricular impairment (left ventricular EF<60% and RV EF≤35%) was found in 34 patients (16%). Pathophysiologic correlates of RV EF were left ventricular septal function (β=0.42, P<0.0001), left ventricular end-diastolic diameter index (β=-0.22, P=0.002), and pulmonary artery systolic pressure (β=-0.14, P=0.047). Mitral effective regurgitant orifice size (n=84) influenced RV EF (β=-0.28, P=0.012). In 68 patients examined after surgery, RV EF increased strongly (27.5±4.3-37.9±7.3, P<0.0001) in patients with depressed RV EF, whereas it did not change in others (P=0.91). RV EF ≤35% impaired 10-year cardiovascular survival (71.6±8.4% versus 89.8±3.7%, P=0.037). Biventricular impairment dramatically reduced 10-year cardiovascular survival (51.9±15.3% versus 90.3±3.2%, P<0.0001; hazard ratio, 5.2; P<0.0001) even after adjustment for known predictors (hazard ratio, 4.6; P=0.004). Biventricular impairment reduced also 10-year overall survival (34.8±13.0% versus 72.6±4.5%, P=0.003; hazard ratio, 2.5; P=0.005) even after adjustment for known predictors (P=0.048).In patients with organic mitral regurgitation referred to surgery, RV function impairment is frequent (30%) and depends weakly on pulmonary artery systolic pressure but mainly on left ventricular remodeling and septal function. RV function is a predictor of postoperative cardiovascular survival, whereas biventricular impairment is a powerful predictor of both cardiovascular and overall survival.
James Malcolm Latham Shearer
Authors: Margaret Shearer, Michael Hamilton, Jonathan Burton
Journal: BMJ (2006)

Former general practitioner Boreham, Essex (b 1923; q King's College Hospital, London, 1947; FRCGP), died from prostate cancer on 2 June 2005.

Malcolm did hospital jobs in Chelmsford and started the first practice in Boreham in 1954, the early practice premises being in the family rented house. The practice expanded over the next 29 years of his career to become one of Essex's leading training and group practices, Malcolm being one of the trainers. He was a keen advocate of home births, at a time when the practice was not widely accepted. His wife, Margaret, worked alongside him as practice nurse and dispenser. He leaves Margaret, three children, and eight grandchildren.
Doctors Resource Service
Authors: Donald L. Madison
Journal: JAMA (1994)

The American Medical Association has produced "Medicine in Transition," the first multimedia "issue" of a projected subscription series on managed care,<i>Doctors Resource Service (DRS)</i>. Packed into a shelf-sized box, the issue contains four handbooks, a videocassette, and an audiocassette. In an introductory letter, AMA executive vice president James Todd, MD, promises his fellow physicians that it "will make you feel better about change and... help you control it," adding the admonition, "Don't panic." Indeed, nothing in the package should induce panic. "Medicine in Transition" is, if anything, pitched to soothe. Its message for the practicing physician is that managed care is not so bad and that acquainting oneself with the concept is the first step in mastering it. The featured item in the package is<i>The Physician and Managed Care</i>, by David Vogel (who also moderates a panel discussion in the videotape). This well-organized 105-page book is informed by
Control of Bleeding After Dental Extraction During Anticoagulant Therapy
Authors: H. J. Roberts
Journal: JAMA (1961)

In patients maintained on long-term anticoagulant therapy the prevention and management of bleeding after dental surgery frequently poses a vexing problem. Results of experience with the intravenous and oral administration of estrogens in 9 such patients are here set forth, and 3 case histories are given in some detail. In most cases the preparation for dental surgery included stopping the oral administration of the anticoagulant for several days and increasing the dose of orally administered estrogen, if the patient had been taking it. Conjugated equine estrogens were administered half an hour before the extraction and given again several hours after.
Genetically Targeted T Cells Eradicate Established Breast Cancer in Syngeneic Mice
Authors: Hao Wang, Huafeng Wei, Ruiping Zhang, Sheng Hou, Bohua Li, Weizhu Qian, Dapeng Zhang, Gen Kou, Jianxin Dai, Yajun Guo
Journal: Clinical Cancer Research (2009)

Abstract Purpose: The purpose of the present study was to evaluate the capacity and mechanisms of genetically modified erbB2-specific T cells to eradicate erbB2+ tumors in syngeneic mice. Experimental Design: Primary mouse T cells were modified to target the breast tumor–associated antigen erbB2 through retroviral-mediated transfer of a chimeric antigen receptor, termed single-chain antibody (scFv)–CD28–ζ. Antitumor efficacy of scFv-CD28-ζ–modified T cells was analyzed in mice bearing D2F2/E2 breast tumors. Results: The scFv-CD28-ζ–modified T cells were shown to specifically secrete T cytotoxic-1 cytokines and lyse erbB2+ breast tumor cells following receptor stimulation in vitro. Treatment with scFv-CD28-ζ–modified T cells was able to lead to long-term, tumor-free survival in mice bearing erbB2+ D2F2/E2 breast tumors. Importantly, the surviving mice developed a host memory response to D2F2/E2 tumor cells, and this host response was able to protect against a rechallenge with erbB2+ D2F2/E2 tumor cells and parental erbB2- D2F2 tumor cells. In addition, scFv-CD28-ζ T-cell expression of perforin and interferon-γ were essential for complete antitumor efficacy. Conclusions: Treatment with scFv-CD28-ζ–modified T cells was able to induce a host antitumor immunity in syngeneic mice. Complete tumor elimination by scFv-CD28-ζ–modified T cells required T cell–derived interferon-γ and perforin, indicating that cytotoxicity and cytokine secretion play a role in the in vivo response.
Inhibition of the TRPC5 ion channel protects the kidney filter
Authors: Thomas Schaldecker, Sookyung Kim, Constantine Tarabanis, Dequan Tian, Samy Hakroush, Philip Castonguay, Wooin Ahn, Hanna Wallentin, Hans Heid, Corey R. Hopkins, Craig W. Lindsley, Antonio Riccio, Lisa Buvall, Astrid Weins, Anna Greka
Journal: Journal of Clinical Investigation (2013)

An intact kidney filter is vital to retention of essential proteins in the blood and removal of waste from the body. Damage to the filtration barrier results in albumin loss in the urine, a hallmark of cardiovascular disease and kidney failure. Here we found that the ion channel TRPC5 mediates filtration barrier injury. Using Trpc5-KO mice, a small-molecule inhibitor of TRPC5, Ca2+ imaging in isolated kidney glomeruli, and live imagining of podocyte actin dynamics, we determined that loss of TRPC5 or its inhibition abrogates podocyte cytoskeletal remodeling. Inhibition or loss of TRPC5 prevented activation of the small GTP-binding protein Rac1 and stabilized synaptopodin. Importantly, genetic deletion or pharmacologic inhibition of TRPC5 protected mice from albuminuria. These data reveal that the Ca2+-permeable channel TRPC5 is an important determinant of albuminuria and identify TRPC5 inhibition as a therapeutic strategy for the prevention or treatment of proteinuric kidney disease.
Abstract 2364: Pancreatic cancer stem-like cells display aggressive behavior mediated through the activation of FoxQ1
Authors: Bin Bao, Asfar Azmi, Aamir Ahmad, Shadan Ali, Yiwei Li, Fazlul H. Sarkar
Journal: Cancer Research (2014)

Abstract Pancreatic cancer (PC) remains as one of the most aggressive and deadly malignant diseases with poorest clinical outcome, and it is the 4th leading cause of cancer-related death in the USA. Higher mortality of patients diagnosed with PC is in part attributed to treatment resistance and early metastatic disease. Sub-populations of cancer cells commonly known as cancer stem cells (CSCs) or cancer stem-like cells (CSLCs) have been identified from most tumors including PC, and the existence of these cells are being recognized to be clinically relevant. Emerging evidence suggests that CSLCs are responsible for many cellular functions including their propensity of increased cell growth/proliferation, migration/invasion, metastasis, and chemo-radio-therapy resistance, all of these attributes lead to poor clinical outcome. However, the pathogenesis and biological significance of CSLCs in PC has not been well characterized. In the present study, we found that triple-marker positive cells (CD44+/CD133+/EpCAM+ cells) cells isolated from human PC cell lines behave like CSCs. These CSLCs exhibit aggressive behavior such as increased cell growth, migration, clonogenicity, and self-renewal capacity. The mRNA expression profiling analysis showed that CSLCs (triple-marker positive cells) exhibit differential expression of more than 1600 mRNAs including Bmi1, BMP4, BST2, BTG1, FOLR1, FoxQ1, PRKAR1A, Sox2, TACSTD2 and Wnt3a, compared to the cells that are triple-marker negative (CD44-/CD133-/EpCAM- cells). The knock-down of FoxQ1 by its siRNA in CSLCs resulted in the inhibition of aggressive behavior, consistent with reduced expression of EpCAM and Snail. These data clearly suggest the role of differentially expressed genes in the regulation of CSLC characteristics, which further suggest that targeting some of these genes in order to eliminate CSLCs could be important for the development of novel therapies for achieving better treatment outcome of patients diagnosed with PC. Citation Format: Bin Bao, Asfar Azmi, Aamir Ahmad, Shadan Ali, Yiwei Li, Fazlul H. Sarkar. Pancreatic cancer stem-like cells display aggressive behavior mediated through the activation of FoxQ1. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2364. doi:10.1158/1538-7445.AM2014-2364