<i>Helicobacter pylori</i> Eradication Therapy for Nonulcer Dyspepsia
Authors: Loren Laine, M. Brian Fennerty, Philip Schoenfeld
Journal: Annals of Internal Medicine (2002)

Letters2 April 2002Helicobacter pylori Eradication Therapy for Nonulcer DyspepsiaLoren Laine, MD, M. Brian Fennerty, MD, and Philip Schoenfeld, MD, MSEdLoren Laine, MDUniversity of Southern California School of Medicine, Los Angeles, CA 90033Oregon Health Sciences University, Portland, OR 97201University of Michigan School of Medicine, Ann Arbor, MI 48105Search for more papers by this author, M. Brian Fennerty, MDUniversity of Southern California School of Medicine, Los Angeles, CA 90033Oregon Health Sciences University, Portland, OR 97201University of Michigan School of Medicine, Ann Arbor, MI 48105Search for more papers by this author, and Philip Schoenfeld, MD, MSEdUniversity of Southern California School of Medicine, Los Angeles, CA 90033Oregon Health Sciences University, Portland, OR 97201University of Michigan School of Medicine, Ann Arbor, MI 48105Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-7-200204020-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Meta-analysis involves more than calculating a summary estimate from an amalgamation of studies. The letter and meta-analysis of Drs. Moayyedi, Deeks, and Forman illustrate the need to assess other factors before drawing conclusions. The widely accepted definition of dyspepsia is upper abdominal pain or discomfort, excluding predominant reflux symptoms. Although Moayyedi and colleagues state that they excluded trials including participants with only reflux symptoms, the two positive trials in their meta-analysis included patients with reflux (1, 2). They report that a third trial was positive, but treatment success, the primary end point, did not improve with therapy (3). ...References1. Malfertheiner P, Fischbach W, Layer P, Moessner J, Stolte M, Leodolter A, et al . ELAN study proves symptomatic benefit of Helicobacter pylori eradication in functional dyspepsia (FD) [Abstract]. Gastroenterology. 2000;118:A440. CrossrefGoogle Scholar2. McColl K, Murray L, El-Omar E, Dickson A, El-Nujumi A, Wirz A, et al . Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med. 1998;339:1869-74. [PMID: 9862941] CrossrefMedlineGoogle Scholar3. des Varannes SB, Flojou JF, Colin R, Zaim M, Meunier A. Helicobacter pylori (HP) eradication in non-ulcer dyspepsia (NUD): a randomized, double-blind, placebo-controlled study with a 12-month follow-up [Abstract]. Gastroenterology. 2000;118:A468. CrossrefGoogle Scholar4. Hsu PI, Lai KH, Tseng HH, Lo GH, Lo CC, Lin CK, et al . Eradication of Helicobacter pylori prevents ulcer development in patients with ulcer-like functional dyspepsia. Aliment Pharmacol Ther. 2001;15:195-201. [PMID: 11148437] CrossrefMedlineGoogle Scholar5. Parsonnet J, Harris RA, Hack HM, Owens DK. Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials. Lancet. 1996;348:150-4. [PMID: 8684154] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Loren Laine, MD; M. Brian Fennerty, MD; Philip Schoenfeld, MD, MSEdAffiliations: University of Southern California School of Medicine, Los Angeles, CA 90033Oregon Health Sciences University, Portland, OR 97201University of Michigan School of Medicine, Ann Arbor, MI 48105 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTherapy for Helicobacter pylori in Patients with Nonulcer Dyspepsia Loren Laine , Philip Schoenfeld , and M. Brian Fennerty Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia Paul Moayyedi , Jonathan Deeks , and David Forman Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia Ward B. Buckingham Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia John M. Bozdech Metrics 2 April 2002Volume 136, Issue 7 Page: 556 Keywords Abdominal pain Gastric cancer Giardiasis Helicobacter pylori Randomized trials Statistical data ePublished: 2 April 2002 Issue Published: 2 April 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...