tbuckley/cabot-search huggingface dataset:
A Relationship Between Rated Ability and Personality Traits in Psychotherapists
Authors: DOUGLAS H. FRAYN
Journal: American Journal of Psychiatry (1968)

Twenty-five psychiatric residents were rated on their ability as psychotherapists by ten supervisors with various theoretical orientations. The high rate of agreement among the supervisors' assessments of competency suggests that there may be "good therapist" characteristics independent of theoretical orientation. The residents were also given three personality questionnaires; the high-ability group was distinguished from the low-ability group by higher scores for scales indicating assertiveness and flexibility and lower scores for rigidity. These findings may have some predictive value in the training of psychotherapists.
STUDIES WITH RADIOACTIVE ENDOTOXIN. III. THE EFFECT OF TOLERANCE ON THE DISTRIBUTION OF RADIOACTIVITY AFTER INTRAVENOUS INJECTION OF ESCHERICHIA COLI ENDOTOXIN LABELED WITH CR511
Authors: F. J. Carey, A. I. Braude, M. Zalesky
Journal: Journal of Clinical Investigation (1958)

ing effects of endotoxin, the following study was undertaken to determine whether tolerant animals owed their resistance to an increased removal of lethal doses of endotoxin from the circulation by the liver and other organs rich in reticuloendothelial cells. EXPERIMENTAL Massive lethal doses of endotoxinAlbino rabbits weighing 2 to 3.5 kilograms and white Swiss mice weighing approximately 20 grams were ob- tained from dealers in Dallas and Austin, Texas.They were housed in air-conditioned quarters.1. Preparation of endotoxin.The endotoxin was pre- pared from Escherichia coli grown in synthetic media and 441
Long-term subthreshold electrical stimulation of the left stellate ganglion and a canine model of sudden cardiac death
Authors: Moshe Swissa, Shengmei Zhou, Ignacio Gonzalez-Gomez, Che-Ming Chang, Angela C. Lai, Adam W. Cates, Michael C. Fishbein, Hrayr S. Karagueuzian, Peng-Sheng Chen, Lan S. Chen
Journal: Journal of the American College of Cardiology (2004)
Too Lazy for Primary Care
Authors: Lynn Bentson
Journal: Annals of Internal Medicine (2014)

Letters4 March 2014Too Lazy for Primary CareLynn Bentson, MDLynn Bentson, MDFrom Albany Internal Medicine Group, Albany, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5005-5 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read Kussmaul's essay (1) with great interest. I have been a primary care provider for 23 years and have worked in a hospital 1 week out of 4 for all of them. The job is impossible; the pay is ridiculous; and, by looking at the cars in the gym parking lot, I can see that the specialists aren't working more hours.Like almost everyone else in primary care, I had family responsibilities that made another 3 to 4 years of fellowship were untenable. Internal medicine, like most of medicine, believes in the brain–uterine shunt. I graduated ...Reference1. Kussmaul WG. Too lazy for primary care? Ann Intern Med. 2013;159:711-2. [PMID: 24247676] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Albany Internal Medicine Group, Albany, Oregon.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0013. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoToo Lazy for Primary Care? William G. Kussmaul III Metrics 4 March 2014Volume 160, Issue 5Page: 368KeywordsConflicts of interestFellowshipsInfantsPregnancy ePublished: 4 March 2014 Issue Published: 4 March 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Decolonization of nostrils and skin of nasal carriers of S. aureus at admission prevented hospital-associated infection
Authors: Yoav Golan
Journal: Annals of Internal Medicine (2010)

ACP Journal Club18 May 2010Decolonization of nostrils and skin of nasal carriers of S. aureus at admission prevented hospital-associated infectionYoav Golan, MDYoav Golan, MDTufts Medical Center, Boston, Massachusetts, USA (Y.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-10-201005180-02009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationBode LG, Kluytmans JA, Wertheim HF, et al. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med. 2010;362:9-17. https://pubmed.ncbi.nlm.nih.gov/20054045Clinical Impact RatingsHospitalists: Infectious Disease: Reference1 Darouiche RO, Wall MJ Jr, Itani KM, et al. Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med. 2010;362:18-26. [PMID: 20054046] Google Scholar Author, Article, and Disclosure InformationAffiliations: Tufts Medical Center, Boston, Massachusetts, USA (Y.G.)This article was published at Annals.org on 4 May 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNasal decontamination for the prevention of surgical site infection in Staphylococcus aureus carriers 18 May 2010Volume 152, Issue 10Page: JC5-9KeywordsHospital medicineHospitalizationsInfectious diseasesMethicillin-resistant staphylococcus aureusOintmentsSkin infectionsSoapsStaphylococcal infectionStaphylococcus aureus ePublished: 18 May 2010 Issue Published: 18 May 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
LIM and SH3 Protein 1 Induces TGFβ-Mediated Epithelial–Mesenchymal Transition in Human Colorectal Cancer by Regulating S100A4 Expression
Authors: Hui Wang, Jiaolong Shi, Yuhao Luo, Qing Liao, Ya Niu, Feifei Zhang, Ziyun Shao, Yanqing Ding, Liang Zhao
Journal: Clinical Cancer Research (2014)

The expression of LIM and SH3 protein 1 (LASP1) was upregulated in colorectal cancer cases, thereby contributing to the aggressive phenotypes of colorectal cancer cells. However, we still cannot decipher the underlying molecular mechanism associated with colorectal cancer metastasis.In this study, IHC was performed to investigate the expression of proteins in human colorectal cancer tissues. Western blot analysis was used to assess the LASP1-induced signal pathway. Two-dimensional difference gel electrophoresis was performed to screen LASP1-modulated proteins and uncover the molecular mechanism of LASP1. TGFβ was used to induce an epithelial-mesenchymal transition (EMT).LASP1 expression was correlated with the mesenchymal marker vimentin and was inversely correlated with epithelial markers, namely, E-cadherin and β-catenin, in clinical colorectal cancer samples. The gain- and loss-of-function assay showed that LASP1 induces EMT-like phenotypes in vitro and in vivo. S100A4, identified as a LASP1-modulated protein, was upregulated by LASP1. Moreover, it is frequently coexpressed with LASP1 in colorectal cancer. S100A4 was required for EMT, and an increased cell invasiveness of colorectal cancer cell is induced by LASP1. Furthermore, the stimulation of TGFβ resulted in an activated Smad pathway that increased the expression of LASP1 and S100A4. The depletion of LASP1 or S100A4 expression inhibited the TGFβ signaling pathway. Moreover, it significantly weakened the proinvasive effects of TGFβ on colorectal cancer cells.These findings elucidate the central role of LASP1 in the TGFβ-mediated EMT process and suggest a potential target for the clinical intervention in patients with advanced colorectal cancer.
OC-037 Vitamin D deficiency is common in intestinal failure patients
Authors: A Culkin, B Rye, C Hanson
Journal: Gut (2012)

<h3>Introduction</h3> Vitamin D is essential due to its role in bone health and its immunomodulatory propeties.<sup>1</sup> Patients with intestinal failure (IF) are at risk of Vitamin D deficiency due to inadequate absorption and lack of exposure to UVB light. Deficiency has been demonstrated in IF patients dependent on home parenteral nutrition.<sup>2</sup> We aimed to determine the prevalence of vitamin D deficiency in hospital patients with IF and the efficacy of subsequent prescribed treatment. <h3>Methods</h3> All patients admitted to St Mark9s Hospital with IF over a 12-month period were included and data on demographics, serum total vitamin D concentration, IF aetiology and vitamin D supplementation prescribed were obtained. If deficiency was identified (≤50 nmol/l) the efficacy of treatment provided was assessed. Descriptive analysis and t-tests were performed. <h3>Results</h3> Eighty-four patients were included in the study (42 female, mean age 53±15 years, 92% Caucasian). The aetiology of IF included short bowel (n=30), fistula (n=34), small bowel obstruction (n=13), malabsorption (n=5) and others (n=2). Vitamin D was measured in 76% (n=64) of patients and 75% (n=48) were deficient (mean 41±25 nmol/l, range 9–126). Vitamin D concentrations were lower in men (33.4±15.3 nmol/l) compared to women (49.5±29.5 nmol/l) (p=0.009). No association was demonstrated with age, aetiology of IF, or ethnicity. There was a trend towards reduced Vitamin D and increasing BMI (p=0.187, r<sup>2</sup>=0.028). No seasonal variation was demonstrated between summer (June–November, 42.8±26.5 nmol/l) and winter (December–May, 39.3±21.6 nmol/l) (p=0.57). Only 26% (n=22) of patients had repeat vitamin D concentrations before discharge. There was a significant increase in vitamin D concentrations from 35±22 nmol/l to 44.8±14.3 nmol/l, (p=0.03). Twenty-nine patients received intramuscular Vitamin D at a dose of 300 000 IU. In these patients there was an increase in concentration before (28.4±13.6 nmol/l) and after (42.8±12.7 nmol/l). Due to the small numbers of patients it was not possible to determine the efficacy of the different vitamin D preparations or the effect of the multivitamin preparation used in parenteral nutrition (Cernevit<sup>®</sup>) on serum concentrations. <h3>Conclusion</h3> Vitamin D deficiency is common and occurs in three-quarters of IF patients. Male gender was associated with lower concentrations. Robust policies need to be in place for the identification of vitamin D deficiency including the supplementation and monitoring of vitamin D deficiency in patients with IF to ensure adequate serum concentrations are achieved. <h3>Competing interests</h3> None declared. <h3>References</h3> 1. <b>Michal L</b>, Melamed. 25-Hydroxyvitamin D levels and the risk of mortality in the general population <i>Arch Intern Med</i> 2008;<b>168</b>:1629. 2. <b>Tee CT</b>, <i>et al.</i> Hypovitaminosis D in patients on long-term parenteral nutrition. <i>Proc Nut Soc</i> 2010;<b>69</b>:E554.
STUDIES ON UROBILIN PHYSIOLOGY AND PATHOLOGY
Authors: Philip D. McMaster, Robert Elman
Journal: The Journal of Experimental Medicine (1925)

Methods have been developed whereby animals can be totally, partially, and intermittently deprived of their bile, without infection of this secretion or of the duct system. In all the instances considered the bile remained sterile throughout the period of the experiment. With this aid we have studied urobilin physiology. We have been able to show that the normal presence of urobilin in the bile and feces of dogs depends on the passage of bile pigment to the intestine, either through the normal channels, or by abnormal ones, as when it is fed by mouth. Complete loss of the bile from the body resulted in the total disappearance of urobilin and urobilinogen from the bile, feces, and urine. Rarely very faint traces remained in the feces, the origin of which has been discussed. Partial loss of the bile resulted in a corresponding reduction in the urobilin of the dejecta. Feedings of sterile urobilin-free dog bile to intubated dogs losing all of their bile and having no urobilin in it, or in feces or urine, were followed by the appearance of the pigment in the hepatic bile secreted shortly thereafter. When the feedings were stopped the urobilin soon disappeared. Total obstruction of the bile flow caused disappearance of the urobilin of the bile and stool. Later as the animals became heavily jaundiced the pigment appeared again in very small quantity in the feces. Autopsy at this time showed that the intestinal mucosa was deeply tinted with bilirubin some of which undoubtedly had passed into the lumen of the bowel and had there been changed to urobilin. Employment of the "altercursive intubation," by which an intermittent diversion of the bile stream of animals from the intestine to a collecting apparatus could be effected, showed that while bile pigment still reached the intestine urobilin was present in the bile secreted by the liver but that almost at once after the bile had been diverted from the gut urobilin disappeared from it. In relation to this finding it was noticed that in animals from which merely a small fraction of the bile was collected, that from a single liver lobe, while the greater portion reached the intestine there was most urobilin in the bile at times when most bilirubin was entering the intestine.
Arg2074Cys missense mutation in the C2 domain of factor V causing moderately severe factor V deficiency: molecular characterization by expression of the recombinant protein
Authors: Stefano Duga, Maria Claudia Montefusco, Rosanna Asselta, Massimo Malcovati, Flora Peyvandi, Elena Santagostino, Pier Mannuccio Mannucci, Maria Luisa Tenchini
Journal: Blood (2002)
Fatal Cases of Poisoning by the Absorption of Carbolic Acid
Authors: E. S. Machin
Journal: BMJ (1868)

THE BITISH MEDICAL 7OUANAL.Emah7, 79Is& many of the nuclear fibres and spindle-shaped cells supposed to be illustrations of the cellular development of fibrous tissue.S. When the disease is not of constitutional origin, there will be found evidence either of the pursuit of some occupation exposing the patient to the inhalation of irritating particles (Peacock; Greenhow), of the existence of tubercular phthisis, long-continued bronchitis, or of some former attack of acute disease, such as fibrinous pleurisy, peri- carditis, or what the author has called the corpuscular form of pneumonia.6.The disease commonly affects one lung, and more commonly the left than the right.7. If the disease affect both lungs, it is as a rule, either the effect of mechanical irritation, or it is accompanied and has probably been caused by the presence of tubercles.In rare cases, the double affection may be caused by rheumatism or syphilis (Wilks).8. In Fibroid Plhthisis there is always contraction of the chest-wall.The percussion dulncss is harder, higher-pitched, and more uniformly continuous than in any other lung-disease.Resistance of the thoracic parietes is greatlyincreased.The intercostal spaces are depressed.Some-
Incidentally Discovered Adrenal Masses*
Authors: RICHARD T. KLOOS, MILTON D. GROSS, ISAAC R. FRANCIS, MELVYN KOROBKIN, BRAHM SHAPIRO
Journal: Endocrine Reviews (1995)

BEFORE 1974, the literature contained 178 clinical cases of nonhypersecretory adrenal cortical tumors (see Table 1 for nomenclature) (4). Since the early 1980s, incidentally discovered adrenal masses have become a common clinical problem as a result of the more widespread use of high resolution anatomical imaging procedures [computed tomography (CT), magnetic resonance imaging (MRI), ultrasound]. In patients without a known extraadrenal primary malignancy, the vast majority of these lesions are benign and nonhypersecretory (Fig. 1) (5, 6). These same lesions are present in a significant fraction (in some series the majority) of incidentally discovered adrenal masses in patients with known extraadrenal primary malignancies. However, it is important to distinguish these benign nonhypersecretory lesions from those in which intervention, or the lack thereof, may alter patient morbidity and mortality. These latter adrenal lesions would include biochemically hypersecretory masses and both primary and metastatic malignancies. The current clinical approach to incidentally discovered adrenal masses must balance diagnostic costs, discomfort, risks, consequences of false-positive results, and low disease prevalence against the value of making an expeditious diagnosis that may result in curative therapy in the minority of patients in whom intervention would be indicated. Widely practiced management algorithms are based heavily upon statistical models attempting to optimize these variables. Anatomical imaging (CT, MRI, and ultrasound) characteristics (7–9) and mass size (10–12) are frequently unable to reliably distinguish between these various etiologies. Fine needle aspiration (FNA) cytology is an invasive procedure with well documented risks of complications. FNA is most helpful in distinguishing adrenal from nonadrenal tissue (e.g. metastases), and is least helpful in distinguishing benign adrenal adenomas from primary adrenocortical carcinomas (4, 13–19). Adrenocortical scintigraphy noninvasively provides functional and anatomical information and is most useful in combination with a preceding biochemical evaluation. The high sensitivity of adrenocortical scintigraphy begins to diminish when mass size is less than 2 cm in diameter (20,21). This article reviews the prevalence of incidentally discovered adrenal masses, their differential diagnosis along with their prevalences, and currently used strategies for evaluation of adrenal masses.
PHOTO-CARCINOGENICITY: THE PHYSICAL BASIS OF ITS EXOGENOUS CAUSES
Authors: W. SUMMER
Journal: British Journal of Dermatology (1980)

Journal Article PHOTO‐CARCINOGENICITY: THE PHYSICAL BASIS OF ITS EXOGENOUS CAUSES Get access W. SUMMER W. SUMMER Rohrmoos, A‐8970 Schladming, Austria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 102, Issue 5, 1 May 1980, Pages 611–619, https://doi.org/10.1111/j.1365-2133.1980.tb07665.x Published: 01 May 1980
HAVE DRUG ADDICTIONS A PATHOLOGIC BASIS?
Authors: ALBERT E. STERNE
Journal: JAMA (1905)

In studying the pathology of drug addiction, it seems to me we have a threefold problem to solve. First, there is the hereditary abnormal aspect—the psycho-cellular pathology; second, the acquired abnormal conditions of the individual, which lead to the use of drug stimulants—the pseudo-pathology; and, third, the effect on the system of the particular drug used—the true pathology of the addiction. <h3>PSYCHO-CELLULAR PATHOLOGY.</h3> I am perfectly well aware that good authorities deny the influence of heredity among drug habitués, but I do not believe that this ground can well be maintained. First of all, it is a matter of record in the study of the histories of a large percentage of habitués of all kinds, that we find taints of varying degree among the ancestors of these individuals. It is a matter of very common occurrence to learn that either one or both parents
Vitamin D Intoxication, with Hypernatraemia, Potassium and Water Depletion, and Mental Depression
Authors: D. C. Anderson, A. F. Cooper, G. J. Naylor
Journal: BMJ (1968)

Two elderly patients suffering from manic-depressive psychosis/depressive reaction had concurrently hypercalcaemia from vitamin D intoxication. They developed hypernatraemia with severe potassium and water depletion. Hypercalcaemia was pronounced, but both patients recovered quickly and their depressive symptoms resolved following water and potassium repletion and corticosteroid therapy.
Hypoglycaemia following Partial Gastrectomy
Authors: J. A. L. Gilbert, D. M. Dunlop
Journal: BMJ (1947)

During a routine follow-up of 45 consecutive patients on whom a partial gastrectomy had been performed for peptic ulcer we noted symptoms of dizziness, palpitation, sweat ing, epigastric discomfort, and a feeling of weakness progressing in several instances to complete loss of con sciousness-in 17. These symptoms, coming on in from one-half to one and a half hours after food, were rapidly relieved by taking sugar or other easily assimilated carbo hydrate. In this series they were far the commonest com plication of partial gastrectomy, being greatly in excess of stomal ulcer and anaemia, which receive such a prominent place in the literature on the subject. Five of the patients were in consequence so severely disabled that they had become totally unfit for employment. Many of them, however, did not associate their symptoms with their oper ation, as their sensations seemed to be quite unconnected with the previous dyspepsia. In a follow-up of patients who have had a partial gastrectomy this syndrome may therefore be overlooked unless leading questions are asked. Such symptoms have been noted previously, chiefly in the German literature by Lapp and Dibold (1933), Beckermann (1933), Koranyi (1936), and Wohrle (1936). Evensen (1942) found that in 34 out of 95 cases of partial gastrectomy the blood sugar fell on occasion to less than 65 mg. per 100 ml. Adlersberg and Hammerschlag (1947), investigating the  post-gastrectomy syndrome, demon strated a hypoglycaemic type of blood-sugar curve in all their 14 cases. There is a curious absence of reference in British literature to post-gastrectomy hypoglycaemia; the dumping syndrome, however, is often mentioned, but is usually attributed to vagotonia, the result of jejunal dis tension from precipitate gastric evacuation.
variations in color naming within and across populations
Authors: michael a. webster, paul kay
Journal: Behavioral and Brain Sciences (2005)

the simulations of steels &amp; belpaeme (s&amp;b) suggest that communication could lead to color categories that are closely shared within a language and potentially diverge across languages. we argue that this is opposite of the patterns that are actually observed in empirical studies of color naming. focal color choices more often exhibit strong concordance across languages while also showing pronounced variability within any language.
Guideline seeks to clarify difference between palliative sedation and euthanasia
Authors: T. Sheldon
Journal: BMJ (2009)

The Dutch Medical Association has issued new guidance on palliative sedation, acknowledging that the practice, increasing in the Netherlands, is more “unmanageable” than it could have foreseen.

The association accepts that its original 2005 guideline failed to properly address concerns about its possible inappropriate use. Some lay people were especially worried about the deep and continuous sedation of terminally ill patients until death.

Fears were raised among people outside the medical profession that doctors could opt for this to avoid the legal requirements to report euthanasia ( BMJ 2007;334:1075, doi:10.1136/bmj.39220.590428.DB).

Marian Verkerk, who chairs the guidelines committee and is professor of medical ethics at Groningen University Medical Centre, accepts …