tbuckley/cabot-search huggingface dataset:
LEFT VENTRICULAR SYSTOLIC DYSSYNCHRONY IS MORE COMMON IN ACUTE DECOMPENSATED THAN CHRONIC STABLE HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Qing Zhang, Yong-Tai Liu, Alex PW Lee, Yu-Jia Liang, Gabriel WK Yip, Rui-Jie Li, Jun-Min Xie, Cheuk-Man Yu
Journal: Journal of the American College of Cardiology (2010)
GMC gives evidence to inquiry
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

Obesity in children in England continues to rise 334 More than one in four children in England are overweight or obese, said a government report published last week which showed that obesity in young people is continuing to rise.The report said that the prevalence of obesity in children aged 2 to 10 increased from 9.9% in 1995 to 13.7% in 2003.The total number of overweight and obese children rose from 22.7% to 27.7% in this period.Obesity increased most in older children aged 8 to 10, rising from 11.2% in 1995 to 16.5% in 2003.Levels of obesity were similar for both sexes, increasing from 9.6% in 1995 to 14.9% in 2003 for boys and from 10.3% to 12.5% for girls.Children living in households with the lowest incomes had higher rates of obesity than those from households with the highest incomes (15.8% v 13.3%).
Medical Behavioral Science
Authors: William D. Weitzel
Journal: JAMA (1975)

This timely volume will serve as an introductory resource book for medical students who must acquaint themselves with the psychosocial influences that mold the lives of their patients and contribute to the changing climate of American medical practice. The editor has three explicit purposes: (1) to define the scope and structure of medical behavior science, (2) to present readers with carefully selected original articles, and (3) to provide a single reference work of sufficient quality to assure adequate student preparation for National Board (part I) questions. This anthology, similar in format to the editor's<i>Theories of Psychopathology</i>, consists of 54 articles organized into 18 different sections. Dr. Millon leads the reader through four major divisions: the organism (Biobehavioral), the person (Psychobehavioral), relationships (Interbehavioral), and cultural aspects (Sociobehavioral). Each major topic and the various subsections are introduced with a brief summary overview and the articles and authors are appropriately placed in
Role of thymic- and graft-dependent mechanisms in tolerance induction to rat kidney transplant by donor PBMC infusion
Authors: R.A. Cavinato, F. Casiraghi, N. Azzollini, M. Mister, A. Pezzotta, P. Cassis, D. Cugini, N. Perico, G. Remuzzi, M. Noris
Journal: Kidney International (2007)
Improved Appraisal of the Quality of Life in Patients with Automatic Implantable Cardioverter Defibrillator
Authors: Philippe Chevalier, Pascal Verrier, Gilbert Kirkorian, Paul Touboul, Jean Cottraux
Journal: Psychotherapy and Psychosomatics (1996)

Patients with an implanted cardioverter defibrillator (ICD) may experience a certain degree of suffering. A sample of 32 patients was surveyed to determine the psychological benefit resulting from this treatment.Hamilton Anxiety Scale, Beck Depression Inventory and a shortened version of the Minnesota Multiphasic Personality Inventory were used. A 10-item scale and a global index of quality of life were especially designed to assess cardioverter defibrillator tolerance and the effect of its implantation on patients' current well-being.Both quality of life index scores were negatively correlated with anxiety and depression. Occurrence of shocks had no influence on psychological well-being.The questionnaires provided a simple and reliable measure of quality of life in ICD patients. Prior to implantation, technical explanations should be accompanied by stress management techniques adapted to the patients' psychological background.
Duty Hour Requirements
Authors: James A. Arrighi, James C. Hebert
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radon and Smoking Status
Authors: Lewis H. Kuller
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The article entitled "Lung Cancer Mortality Among Non-smoking Uranium Miners Exposed to Radon Daughters"<sup>1</sup>is an important contribution. The conclusions, however, are not consistent with the results presented in the article. The authors list nine standard categories of exposure. Ten of 14 lung cancer deaths would be in category 7, which is 840 or more working level months (WLM), and all are above category 5, which is 360 or more WLM. The authors then collapse the categories to two and conclude a 12-fold risk at a median of 296 WLM and a mean of 720 WLM. There were no lung cancers below the median of 296 WLM and only 3 below the mean of 720 WLM. The lack of power at lower doses is clearly a problem, but does not justify an arbitrary division of their population so that the reported level of risk is much
Monitoring for Mendacity
Authors: Samuel Vaisrub
Journal: JAMA (1979)

It may be more than a coincidence that Sir Arthur Conan Doyle, the creator of Sherlock Holmes, was a physician. The observant eye and deductive logic of the detective prototype are also hallmarks of the astute physician who seeks clues to diagnosis or who traces the source of an epidemic. Kinship between the two callings becomes even closer when a pathologist aids in solving a crime or a clinician uses his skill to detect deception on the part of a patient. Deception by patients takes many forms. It may be deliberate in malingering, subconsciously motivated in hysteria, shamefully concealed in child abuse, and self-destructive in the Munchausen syndrome. More commonly, deception manifests itself as noncompliance with physicians' orders. Physicians are well aware of noncompliance. They suspect it whenever a patient does not respond as expected to prescribed therapy, be it exercise, medication, or a restricted diet. Justly or unjustly, they
A mutation in SART3 gene in a Chinese pedigree with disseminated superficial actinic porokeratosis
Authors: Z.H. Zhang, Z.M. Niu, W.T. Yuan, J.J. Zhao, F.X. Jiang, J. Zhang, B. Chai, F. Cui, W. Chen, C.H. Lian, L.H. Xiang, S.J. Xu, W.D. Liu, Z.Z. Zheng, W. Huang
Journal: British Journal of Dermatology (2005)

Background Disseminated superficial actinic porokeratosis (DSAP) is an uncommon autosomal dominant chronic disorder of keratinization, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border. Thus far, although two loci for DSAP have been identified, and the genetic basis and pathogenesis of this disorder have not been elucidated. Objectives To determine the locus of DSAP and identify the candidate gene(s) of the disease. Methods Genome-wide scan and linkage analysis were performed in a six-generation Chinese family with DSAP. The coding exons of the candidate genes were sequenced to analyse and detect the nucleotide variations. Results Linkage analysis showed that the maximum two-point lod score of 5·56 was obtained with the marker D12S79 at a recombination fraction θ of 0·00. Haplotype analysis defined the critical region for DSAP between D12S330 and D12S1612 on 12q24.1–24.2. By sequence analysis, we found a Val591Met mutation in SART3 in all affected individuals of the family. Conclusion SART3 is a candidate gene for DSAP, and is possibly involved in the pathogenesis of DSAP.
Response to neoadjuvant chemotherapy in patients with triple negative breast cancer.
Authors: E Abe, N Hayashi, A Yoshida, T Hamaoka, H Yagata, K Tsugawa, H Tsunoda-Shimizu, K Suzuki, S Nakamura
Journal: Cancer Research (2009)

Abstract Abstract #6069 Background:&amp;#x2028; Triple negative breast cancer (TNBC) is defined by the lack of estrogen receptor(ER), progesterone receptor (PR), and human epidermal growth factor receptor2 (HER-2) expression. TNBC has poor outcome due to no specific therapeutic agents. But TNBC includes two major phenotypes, basal-like and non basal-like phenotypes. Basal-like phenotype has poor prognosis and is associated with positive expression of basal markers. We compared response to neoadjuvant chemotherapy between patients with TNBC and non-TNBC, in addition, basal-like and non basal-like phenotype.&amp;#x2028; Material and Methods:&amp;#x2028; We retrospectively reviewed a total of 1948 operated patients with a diagnosis of primary breast cancer from November 2002 to December 2006 at St. Luke's International Hospital. 369 (18.9%) patients received neoadjuvant chemotherapy. Clinical and pathological response rates, survival measurements and relapse rates were compared between patients with TNBC and non-TNBC. Clinical response was determined by MRI or CT which was performed before and after neoadjuvant chemotherapy. Histopathological parameter(ER, PGR, HER-2, nuclear grade, mitosis) were confirmed from the specimens of needle biopsy performed before treatment. The specimens were also stained with basal markers (cytokeratin 5/6 and EGFR) to identify basal-like phenotype in TNBC. Basal-like phenotype was defined by the expression of CK5/6 and/or EGFR in &amp;gt;10% of tumor cells.&amp;#x2028; Results:&amp;#x2028; Fifty-four of 369 patients (14.6%) had TNBC. Progressive disease (PD) rate was significantly higher in patients with TNBC than those patients with non-TNBC (20.7% v 2.3%).And pathologic complete response rate (pCR) was also higher in patients with TNBC than those patients with non-TNBC (17% v 9.6%).14of 48 patients (29.1%) was diagnosed as Basal-like phenotype in TNBC. Clinical response rate for basal-like phenotype was worse than non basal-like phenotype (42.9% v 67.6%). Furthermore, both disease free survival and overall survival for basal-like subtype were significantly worse than non basal-like phenotype (p&amp;lt;0.05).Other parameters including age, histological grade, and tumor size were not significant for response to neoadjuvant chemotherapy.&amp;#x2028; Conclusions:&amp;#x2028; Patients with TNBC have higher PD rate but also pCR rate to treatment compared with non TNBC. Furthermore, basal-like phenotype could predict poor prognosis. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6069.
Medical Life in Warsaw
Authors: James H. Currens
Journal: New England Journal of Medicine (1959)

THE following account is that of a motor tour through Czechoslovakia and Poland in October, 1958. It is not intended as a study of medical life or practice in either Czechoslovakia or Poland but merely as a report of a few interesting observations made during the trip.The Poles in Warsaw talked freely and were eager to discuss politics. Freedom of speech has been present since 1956 although the press is still well controlled by the government. It is a peculiar experience, however, to live in a city even for a few days where everything is state owned and state . . .
Pimecrolimus cream 1% in the long-term management of adult atopic dermatitis: prevention of flare progression. A randomized controlled trial
Authors: H. Gollnick, R. Kaufmann, D. Stough, H. Heikkila, K. Andriano, A. Grinienko, P. Jimenez
Journal: British Journal of Dermatology (2008)

Journal Article Pimecrolimus cream 1% in the long‐term management of adult atopic dermatitis: prevention of flare progression. A randomized controlled trial Get access H. Gollnick, H. Gollnick Universitätsklinikum für Dermatologie und Venerologie, Otto‐von‐Guericke‐Universität Magdeburg, 39120 Magdeburg, Germany Correspondence: Harald Gollnick. E‐mail: harald.gollnick@medizin.uni‐magdeburg.de Search for other works by this author on: Oxford Academic Google Scholar R. Kaufmann, R. Kaufmann Universitätsklinikum Frankfurt, Frankfurt, Germany Search for other works by this author on: Oxford Academic Google Scholar D. Stough, D. Stough Burke Pharmaceutical Research, Hot Springs, AR, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar H. Heikkila, H. Heikkila HUS, Iho‐ja Allergiasairaala, Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar K. Andriano, K. Andriano Novartis Pharmaceuticals Corporation, East Hanover, NJ, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar A. Grinienko, A. Grinienko Novartis Pharmaceuticals Corporation, East Hanover, NJ, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar P. Jimenez, P. Jimenez Novartis Pharmaceuticals Corporation, East Hanover, NJ, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar Pimecrolimus Cream 1% in (adult) Eczema: Prevention of Progression Multicentre Investigator Study Group Pimecrolimus Cream 1% in (adult) Eczema: Prevention of Progression Multicentre Investigator Study Group Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 5, 1 May 2008, Pages 1083–1093, https://doi.org/10.1111/j.1365-2133.2008.08484.x Published: 01 May 2008
Severe upper gastrointestinal hemorrhage from linear gastric ulcers in large hiatal hernias: a large prospective case series of Cameron ulcers
Authors: M. Camus, D. Jensen, G. Ohning, T. Kovacs, K. Ghassemi, R. Jutabha, G. Machicado, G. Dulai, O. Hines
Journal: Endoscopy (2013)

We report a case series of all consecutive patients hospitalized in our two tertiary referral medical centers over the past 17 years for Cameron ulcers causing severe upper gastrointestinal hemorrhage (GIH) or severe obscure GIH. Cameron ulcers were diagnosed in 25 of the 3960 screened patients with severe upper GIH or severe obscure GIH (0.6 %). Of these, 21 patients had a prospective follow-up (median time 20.4 months [interquartile range: 8.5 - 31.8]). Patients were more often elderly women with chronic anemia, always had large hiatal hernias, and were usually referred for obscure GIH. Twelve of the 21 patients (57 %) were referred for surgery while being treated with high-dose proton pump inhibitors (PPIs). The other 9 patients (43 %) continued PPIs without any rebleeding during the follow-up. Cameron ulcers in large hiatal hernias are an uncommon cause of severe upper GIH. The choice of medical vs. surgical therapy should be individualized.
Development of Endocrine Function in the Human Placenta and Fetus
Authors: Dorothy B. Villee
Journal: New England Journal of Medicine (1969)

FROM the moment of conception an interplay of biochemical processes ensures the growth and development of the fetus and its placenta. Such an interplay must function under an intricate system of controls of which we have only limited knowledge. The efforts of many investigators have accumulated a wealth of data relating to steroid metabolism that have suggested a collaborative enterprise between fetus and placenta. These data are examined in the special context of a "fetoplacental unit," and an attempt is made to place the steroid story in perspective along with other aspects of fetal and placental endocrinology.† For the reader . . .
A Case in which the Radical Cure of Hernia was Performed by an Unusual Method
Authors: J. Murphy
Journal: BMJ (1887)

THIS BRITISH MBDICAL JOt1NAL.1327 strict Listerism was followed out, and as a rule not more than one or two dressings were required.The ages of the patient varied from 3 months to 76 years, the rup- tures being ventral, femoral, inguinal, or inguino-scrotal.The greater number appeared to be permanently cured, and it seemed to be quite unnecessary to recommend a truss, unless, as in Case 3, the opening into the abdomen had been unusually large.Cases 5 and 13 require special notice, as they both succumbed to bronchitis, but in both the necropsy clearly proved that the site of
Remarks on the Function of the Thyroid Gland: A Critical and Historical Review
Authors: V. Horsley
Journal: BMJ (1892)

and (2) that extirpation of the Gasserian ganglion through the base of the skull, though admittedly a diffieult undertaking, need not endanger life, and at present holds out the best prospect in dealing with the intractable forms of trigeminal tic.[During th4-lecture, which was illustrated by diagrams and microscopical specimens, Mr. Rose demonstrated the different stages of the operation on the cadaver.]
Smoke free hospitals: Challenges need to be faced
Authors: W. McKee
Journal: BMJ (2003)

EDITOR—McKee et al criticised our decision to provide smoking rooms for patients' use.1 We have also trained a substantial number of clinical staff to offer opportunistic advice about smoking cessation, offering nicotine replacement to all smokers who are admitted.

Jarvis et al drew attention to the prevalence of “hardcore” smoking in England and its links with age and socioeconomic deprivation.2 Most patients in the …
Patient Casemix Classification for Medicare Psychiatric Prospective Payment
Authors: Edward M Drozd, Jerry Cromwell, Barbara Gage, Jan Maier, Leslie M Greenwald, Howard H Goldman
Journal: American Journal of Psychiatry (2006)

Objective: For a proposed Medicare prospective payment system for inpatient psychiatric facility treatment, the authors developed a casemix classification to capture differences in patients' real daily resource use. Method: Primary data on patient characteristics and daily time spent in various activities were collected in a survey of 696 patients from 40 inpatient psychiatric facilities. Survey data were combined with Medicare claims data to estimate intensity-adjusted daily cost. Classification and Regression Trees (CART) analysis of average daily routine and ancillary costs yielded several hierarchical classification groupings. Regression analysis was used to control for facility and day-of-stay effects in order to compare hierarchical models with models based on the recently proposed payment system of the Centers for Medicare & Medicaid Services. Results: CART analysis identified a small set of patient characteristics strongly associated with higher daily costs, including age, psychiatric diagnosis, deficits in daily living activities, and detox or ECT use. A parsimonious, 16-group, fully interactive model that used five major DSM-IV categories and stratified by age, illness severity, deficits in daily living activities, dangerousness, and use of ECT explained 40% (out of a possible 76%) of daily cost variation not attributable to idiosyncratic daily changes within patients. A noninteractive model based on diagnosis-related groups, age, and medical comorbidity had explanatory power of only 32%. Conclusions: A regression model with 16 casemix groups restricted to using "appropriate" payment variables (i.e., those with clinical face validity and low administrative burden that are easily validated and provide proper care incentives) produced more efficient and equitable payments than did a noninteractive system based on diagnosis-related groups.
Scapulo-Humeral Periarthritis
Authors: A. H. Douthwaite
Journal: BMJ (1938)

JBORNAL 441 histologically the only definite change is a slight decrease in the size of the lobules.3. Injections of androsterone, androstanediol, trans- dehydroandrosterone, testosterone, and testosterone propionate returned the liver of most castrated rats towards or to normal weight and structure, while testosterone and testosterone propionate had no appreciable effect upon the liver of normal rats.4. The absence of pathological changes in the small '>,astration" liver and in this organ enlarged after injec- t4ns of the above sexual hormones, as well as the nature o6 the changes observed, suggests a natural stimulating Ation of these hormones on the liver.5. This might have a practical significance in therapy of the liver and some metabolic disturbances if the same effect of these hormones be found in the case of human liver.6. Injections of oestrone or oestradiol into castrated rats in the doses used caused a decrease in weight of the liver to below that of the control rats but no definite histological changes.The changes in weight observed are probably due chiefly to the depressing effect of oestrogens on the appetite, with resulting decrease in gain of body weight and weight of different organs, including the liver.Grants from the Medical Research Council and from the Lister Institute have enabled us to carry out this work, and to them our thanks are due.We are also indebted to Pro- fessor A. Girard for oestrone and oestradiol, and to Messrs. Ciba, Ltd., in particular to Dr. K. Miescher, for all the other hormones used.
Placebo management of psychogenic disease
Authors: E Ernst
Journal: Journal of the Royal Society of Medicine (2007)

In the letter we call on Reed to cease all involvement in arms fairs.In particular we state that Reed's involvement in the arms trade 'is entirely at odds with the ethical and social obligations we have to promote the beneficial applications of our work and prevent its misuse, to anticipate and evaluate the possible unintended consequences of scientific and technological developments, and to consider at all times the moral responsibility we carry for our work.'
Age-Related Testosterone Depletion and the Development of Alzheimer Disease
Authors: E. R. Rosario
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal