Cost-Effectiveness of Statins Added to Aspirin Therapy
Authors: Michael Pignone
Journal: Annals of Internal Medicine (2006)

Letters1 August 2006Cost-Effectiveness of Statins Added to Aspirin TherapyMichael Pignone, MD, MPHMichael Pignone, MD, MPHFrom the University of North Carolina–Chapel Hill, Chapel Hill, NC 27599-7110.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-3-200608010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: The effectiveness of high-dose statins or combination lipid-lowering therapy for primary prevention of CHD events has not been studied to date and was not included as part of our model. The trials that formed the basis of our estimates of costs and effectiveness in CHD risk reduction used low to medium doses of a single agent and minimal or no adjustment based on lipid levels (1). If more aggressive lipid-lowering treatment were to be found more effective in CHD event prevention, then further analyses would need to consider whether the additional costs and potential increase in adverse effects ...References1. Pignone M, Phillips C, Mulrow C. Use of lipid lowering drugs for primary prevention of coronary heart disease: meta-analysis of randomised trials. BMJ. 2000;321:983-6. [PMID: 11039962] CrossrefMedlineGoogle Scholar2. Prosser LA, Stinnett AA, Goldman PA, Williams LW, Hunink MG, Goldman L, et al. Cost-effectiveness of cholesterol-lowering therapies according to selected patient characteristics. Ann Intern Med. 2000;132:769-79. [PMID: 10819699] LinkGoogle Scholar3. Pickin DM, McCabe CJ, Ramsay LE, Payne N, Haq IU, Yeo WW, et al. Cost effectiveness of HMG-CoA reductase inhibitor (statin) treatment related to the risk of coronary heart disease and cost of drug treatment. Heart. 1999;82:325-32. [PMID: 10455083] CrossrefMedlineGoogle Scholar4. Pignone M, Saha S, Hoerger T, Lohr KN, Teutsch S, Mandelblatt J. Challenges in systematic reviews of economic analyses. Ann Intern Med. 2005;142:1073-9. [PMID: 15968032] LinkGoogle Scholar5. Rodondi N, Peng T, Karter AJ, Bauer DC, Vittinghoff E, Tang S, et al. Therapy modifications in response to poorly controlled hypertension, dyslipidemia, and diabetes mellitus. Ann Intern Med. 2006;144:475-84. [PMID: 16585661] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of North Carolina–Chapel Hill, Chapel Hill, NC 27599-7110.Disclosures:Consultancies: Bayer; Honoraria: Bayer, Pfizer; Expert testimony: Bayer; Grants received: Bayer, Pfizer. The University of North Carolina–Chapel Hill has received licensing fees from Bayer. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness of Cholesterol-Lowering Therapies according to Selected Patient Characteristics Lisa A. Prosser , Aaron A. Stinnett , Paula A. Goldman , Lawrence W. Williams , Maria G.M. Hunink , Lee Goldman , and Milton C. Weinstein Challenges in Systematic Reviews of Economic Analyses Michael Pignone , Somnath Saha , Tom Hoerger , Kathleen N. Lohr , Steven Teutsch , and Jeanne Mandelblatt Challenges in Systematic Reviews of Economic Analyses Michael Pignone , Somnath Saha , Tom Hoerger , Kathleen N. Lohr , Steven Teutsch , and Jeanne Mandelblatt Aspirin, Statins, or Both Drugs for the Primary Prevention of Coronary Heart Disease Events in Men: A Cost–Utility Analysis Michael Pignone , Stephanie Earnshaw , Jeffrey A. Tice , and Mark J. Pletcher Therapy Modifications in Response to Poorly Controlled Hypertension, Dyslipidemia, and Diabetes Mellitus Nicolas Rodondi , Tiffany Peng , Andrew J. Karter , Douglas C. Bauer , Eric Vittinghoff , Simon Tang , Daniel Pettitt , Eve A. Kerr , and Joe V. Selby Cost-Effectiveness of Statins Added to Aspirin Therapy Mark K. Chelmowski Metrics 1 August 2006Volume 145, Issue 3Page: 233-234KeywordsConflicts of interestLipidsStatins ePublished: 1 August 2006 Issue Published: 1 August 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...