tbuckley/cabot-search huggingface dataset:
ADJUSTMENT OF SIBLINGS IN LARGE FAMILIES
Authors: JAMES H. S. BOSSARD, ELEANOR STOKER BOLL
Journal: American Journal of Psychiatry (1956)

The personal adjustment of 457 large family siblings, as made by the informants in 58 families, shows the following results. 1. Approximately 2 of 3 siblings were reported as well adjusted, one of 4 was medium in his adjustment, and one of 9 was poorly adjusted. 2. A larger proportion of male siblings than of female were well adjusted, and of medium adjustment. 3. In-between children show higher rates of good and medium adjustment than do the first and last born. Of the latter 2 groups, the last-born have the better record. 4. First-born children have the poorest record and fourth-born by far the best record. 5. Poorly adjusted children, considered collectively, tend to be grouped in homes in which the father is domineering, or the mother is ineffective and irresponsible, in which the children are exploited, and where health problems abound.
Effect of a regional neonatal unit on a general paediatric ward.
Authors: A Greenough, N R Roberton
Journal: BMJ (1985)

recurrences developed within one year, most within six months.1 °Thus our success rate of 64% after 13-18 months' follow up probably reflects the long term cure rate for cryotherapy in an unselected group of patients with ingrowing toenails.This success rate might be increased if cryotherapy was combined with a method of reducing the bulk of the nail fold, either by resection of soft tissue or by an increased freeze time.Although nail reducing techniques are the most successful, patients may not be willing to lose permanently part or all of their toenail if a nail sparing technique would succeed.Even the most basic of these techniques, however, requires an anaesthetic, skill of the operator, suitable operating facilities, and time.Cryotherapy, however, is a quick, simple, and cheap nail sparing procedure that can be carried out without anaesthe- sia with limited facilities, has a rate of success comparable with that of surgical nail sparing procedures, and produces rapid relief of pain in most cases.
Death from Antitoxin.
Authors: James L. Taylor
Journal: JAMA (1896)

Wheelersburg, Ohio, March 27, 1896. <h3>To the Editor:</h3> —A most unfortunate and distressing accident occurred in the practice of Dr. S. S. Halderman, of Portsmouth, Ohio, on March 22, in connection with the use of antitoxin. A mild form of diphtheria was prevailing in the family of Mr. George Kricker, cashier of the Central Savings Bank, and the doctor administered the usual dose of antitoxin, as a prophylactic, to a little boy, 5 years old, in whom the disease had not yet appeared. The child, which had seemed to be in perfect health up to this time, was asleep when the injection was given, and in five minutes was a corpse. The doctor had withdrawn to another room to refill his syringe for use on another child, when the mother noticed the boy's lips puffing up and called to him that something was wrong with Willie. By the time the
Immune response of infants and preschool children to typhoid vaccine given intradermally or subcutaneously.
Authors: V. Mohandas, T. Cherian, G. Sridharan, E. A. Simoes, S. M. Pereira, T. J. John
Journal: BMJ (1989)

arterial pressure, causing natriuresis, which leads to depletion of sodium and further raises the angiotensin II concentration.5Given that the blood pressure of patients with the hyponatraemic hypertensive syndrome is renin dependent, our patients' pro- nounced hypotensive response to atenolol is not surprising.The correct management of patients with this syndrome is unclear.It is not known whether blood pressure falls precipitously in all patients who take 3 blockers or how far the risk of hypotension extends to those who take other classes of drugs.Bethanidine and captopril have been reported as causing serious hypotension,' 5and we recommend that they be avoided as initial treatment.We conclude that patients with malignant hyper- tension and hypokalaemia or hyponatraemia should be treated with low doses of (i blockers that can be raised according to the response of the blood pressure.Any precipitous fall in blood pressure can be reversed by a prompt infusion of saline, although temporary inotropic support may also be required.I Graham DI.Ischaemic brain damage of cerebral perfusion type after treatment of severe hypertension.
Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML
Authors: Jeffrey E. Lancet, Jorge E. Cortes, Donna E. Hogge, Martin S. Tallman, Tibor J. Kovacsovics, Lloyd E. Damon, Rami Komrokji, Scott R. Solomon, Jonathan E. Kolitz, Maureen Cooper, Andrew M. Yeager, Arthur C. Louie, Eric J. Feldman
Journal: Blood (2014)
A Large Urban Outbreak of Histoplasmosis: Clinical Features
Authors: LAWRENCE JOSEPH WHEAT
Journal: Annals of Internal Medicine (1981)

An outbreak of histoplasmosis estimated to involve more than 100 000 residents in Indianapolis, Indiana, occurred between September 1978 and August 1979. In the 435 cases evaluated, 52% of the patients were between 15 and 34 years old, and 63% were black. Fifteen patients died, and 46 had progressive disseminated infection. Twenty-four patients had pericarditis, and 26 had rheumatologic syndromes. Unusual manifestations that occurred in 18 patients included esophageal and vocal cord ulcers, parotitis, adrenal insufficiency, uveitis, fibrosing mediastinitis, interstitial nephritis, intestinal lymphangiectasia, and epididymitis. The highest attack rate was in the central part of the city, which is a densely populated, disproportionately black section. The source of the outbreak has not been proved by positive culture results; two sites, however, were suspected on an epidemiologic basis.
Treating overdose with calcium channel blockers
Authors: J Kenny
Journal: BMJ (1994)

a high continuation rate of 95% at 12 months.9Second generation implants may be even more cost effective, and the intrauterine device that releases levonorgestrel will be an important option for women over 35.Other problems that have emerged with implanted levonorgestrel are the responsibility for prescription if the general practitioner cannot insert it and the fear that family planning clinics will transfer its cost on to general practitioners if they decide not to purchase it.In these wranglings women's choice to have the implant inserted (or removed without delay) should not be denied.Third generation intrauterine devices with greater than 350 mm2 surface area of copper confer substantially better protection against both intrauterine and ectopic pregnancy than previously available intrauterine devices.'0The great advantages of intrauterine devices that release levonorgrestrel over conventional devices are that while effectively preventing pregnancy, they are associated with appreciably less menstrual blood loss, leading to amenorrhoea in some women."Once again, return to fertility after discontinuation seems no different from that in fertile women not using contraception."Britain's general household survey of 1991 found that one in five women exposed to pregnancy used no method of contraception.'3Studies from the United States have shown that about half of unwanted pregnancies result from contraceptive failure and the other half from women using no method of contraception.'4In a country where 1 in 5 conceptions results in an abortion these methods would be a valuable addition to the armamentarium against unwanted pregnancy.
Self‐assembly of Cytotoxic Peptide Amphiphiles into Supramolecular Membranes for Cancer Therapy
Authors: R. Helen Zha, Shantanu Sur, Samuel I. Stupp
Journal: Advanced Healthcare Materials (2012)

Peptide amphiphiles (PAs) provide a versatile platform for the design of complex and functional material constructs for biomedical applications. The hierarchical self-assembly of PAs with biopolymers is used to create robust hybrid membranes with molecular order on the micron scale. Fabrication of membranes by assembling hyaluronic acid with positively charged PA nanostructures containing anti-cancer PAs bearing a (KLAKLAK)(2) peptide sequence is reported here. Changes in membrane microstructure as the positively charged PA nanostructures vary from cylindrical nanofibers to spherical aggregates are characterized. Results indicate that formation of highly aligned fibrous membranes requires a threshold concentration of nanofibers in solution. Additionally, variation of PA nanostructure morphology from spherical aggregates to cylindrical nanofibers allows membranes to act either as reservoirs for sustained release of cytotoxicity upon enzymatic degradation or as membranes with surface-bound cytotoxicity, respectively. Thus, the self-assembly processes of these PA-biopolymer membranes can be potentially used to design delivery platforms for anti-cancer therapeutics.
Anti-CD20 Antibody Therapy for B-Cell Lymphomas
Authors: David G. Maloney
Journal: New England Journal of Medicine (2012)

A 62-year-old man receives a diagnosis of diffuse large B-cell lymphoma; treatment with a regimen including the anti-CD20 antibody rituximab is recommended. Rituximab has been shown to improve progression-free survival when added to standard chemotherapy regimens for lymphoma.
Facts and fallacies about gall stones
Authors: J. Fielding
Journal: BMJ (1981)

and the astute pathologist (I)r D Eakins) noted that the lymph node attached to the gall bladder showcd classical sarcoid.When she Xwas admitted on that occasion hcr x-ray film showed infiltrative changes and her EGG showed first-degree heart block xwith dropped beats and left bundle-branch block.''hus there was definite active sarcoidosis at the age of 88 years, though not actually "acute sarcoidosis" as rcported by Dr Brown and his colleagues.
TCT-7 Impact Of Early Versus Late Clopidogrel Discontinuation On Stent Thrombosis Following Percutaneous Coronary Intervention With First- And Second-Generation Drug-Eluting Stents
Authors: Joshua P. Loh, Salem Badr, Israel Barbash, Fang Chen, Kenneth Kent, Hironori Kitabata, Marco A. Magalhaes, Sa'ar Minha, Al Fazir Omar, Hideaki Ota, lakshmana Pendyala, Augusto Pichard, Lowell F. Satler, William O. Suddath, Rebecca Torguson, Ron Waksman
Journal: Journal of the American College of Cardiology (2013)
THE PSYCHOLOGY OF THE NORMAL CHILD
Authors: OLGA BRIDGMAN
Journal: JAMA (1923)

The mind of the child differs from that of the adult quite as much, and in much the same way, as his body differs from that of the adult. Certain traits are his at birth and are modifiable only to a slight degree; on the other hand, changes for good or ill can be wrought in his mind which are as marked as are the changes sometimes seen in the bodies of certain primitive peoples who mold heads and alter features after a marvelous fashion.  Every child comes into the world with a set of tendencies transmitted through the ages from two long lines of ancestors. He is what he is largely because of his family, his sex and his race. Education may do much to develop small or latent powers, but nature has set definite limits for each individual beyond which he cannot go. It is futile to try
Efficacy of Erlotinib for Brain and Leptomeningeal Metastases in Patients with Lung Adenocarcinoma Who Showed Initial Good Response to Gefitinib
Authors: Tatsuya Katayama, Junichi Shimizu, Kenichi Suda, Ryoichi Onozato, Takayuki Fukui, Simon Ito, Shunzo Hatooka, Taijiro Sueda, Toyoaki Hida, Yasushi Yatabe, Tetsuya Mitsudomi
Journal: Journal of Thoracic Oncology (2009)
Improving Opioid Prescribing
Authors: David N. Juurlink, Irfan A. Dhalla, Lewis S. Nelson
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sleepiness: Causes, Consequences and Treatment
Authors: Marcel Hungs
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maternal Cocaine Use During Early Pregnancy as a Risk Factor for Congenital Urogenital Anomalies
Authors: Gilberto F. Chávez
Journal: JAMA (1989)

To study the association of maternal cocaine use during early pregnancy with the occurrence of congenital urogenital anomalies, we analyzed data from the population-based Atlanta Birth Defects Case-Control Study. We identified 276 and 791 case-babies with urinary and genital anomalies, respectively, who were live born and stillborn to residents of metropolitan Atlanta from 1968 through 1980. There were 2835 and 2973 respective control-babies born without birth defects randomly selected through birth certificates. Maternal cocaine use during early pregnancy was defined as reported use at any time from 1 month before the pregnancy began through the first 3 months of pregnancy. We found a statistically significant association of reported cocaine use with an increased risk for urinary tract defects (crude odds ratio, 4.39; 95% confidence interval, 1.12 to 17.24) and no statistically significant association with genital organ defects (odds ratio, 2.26; confidence interval, 0.67 to 7.62). The findings from this study were consistent with a previously reported association of maternal cocaine use and urinary tract anomalies in animal and clinical studies.
Oestrogen and colonic epithelial cell growth.
Authors: S Singh, M J Langman
Journal: Gut (1995)

Leading articleOestrogen and colonic epithelial cell growth Oestrogen may play a physiological part in regulation of colonic epithelium cell growth and the development of large bowel cancer.Circulating oestrogens are present in men in similar concentration to that found in post- menopausal woman, and oestrogen receptors have been shown in various sites including bone, liver, and kidney.This article reviews the evidence for oestrogen action in the large bowel.Oestrogen exposure and incidence of large bowel cancer
An Address on the Present Position of State Medicine in England
Authors: A. Ransome
Journal: BMJ (1877)

It has long been established that individuals with anxiety disorders tend to overgeneralize attributes of fearful stimuli to non-fearful stimuli, but there is little mechanistic understanding of the neural system that supports overgeneralization. To address this gap in our knowledge, this study examined effect of experimentally-induced anxiety in humans on generalization using the behavioral pattern separation (BPS) paradigm. Healthy subjects of both sexes encoded and retrieved novel objects during periods of safety and threat of unpredictable shocks, while we recorded brain activity with fMRI. During retrieval, subjects were instructed to differentiate among new, old, and altered images. We hypothesized that the hippocampus and dorsolateral prefrontal cortex (dlPFC) would play a key role in the effect of anxiety on BPS. The dlPFC but not the hippocampus showed increased activity for altered images compared to old images when retrieval occurred during periods of threat compared to safe. In addition, accuracy for altered items retrieved during threat was correlated with dlPFC activity. Together these results suggest that overgeneralization in anxiety patients may be mediated by an inability to recruit the dlPFC, which mediates the cognitive control needed to overcome anxiety and differentiate between old and altered items during periods of threat. <b>SIGNIFICANCE STATEMENT</b> Anxiety and PTSD patients generalize fear to non-fearful fear stimuli, making it difficult to regulate anxiety. Understanding how anxiety affects generalization is key to understanding the overgeneralization experienced by these patients. We examined this relationship in healthy subjects by studying how threat of shock impacts neural responses to previously encountered stimuli. Although previous studies point to hippocampal involvement, we found that threat impacted activity in the dorsolateral prefrontal cortex (dlPFC), rather than the hippocampus, when subjects encountered slightly altered versions of the previously encountered items. Importantly this dlPFC activity predicted performance for these items. Together these results suggest that the dlPFC is important for discrimination during elevated anxiety, and that overgeneralization may reflect a deficit in dlPFC mediated cognitive control.
Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia
Authors: A Jiménez-Velasco, J Román-Gómez, X Agirre, M Barrios, G Navarro, I Vázquez, F Prósper, A Torres, A Heiniger
Journal: Leukemia (2005)
Impact of Coagulation-Balance Gene Predictors on Efficacy of Photodynamic Therapy for Choroidal Neovascularization in Pathologic Myopia
Authors: Francesco Parmeggiani, Donato Gemmati, Ciro Costagliola, Francesco Semeraro, Sergio D'Angelo, Paolo Perri, Adolfo Sebastiani, Carlo Incorvaia
Journal: Ophthalmology (2009)
Epidemiologic, Clinical, and Laboratory Findings of Human Ehrlichiosis in the United States, 1988
Authors: Thomas R. Eng
Journal: JAMA (1990)

In 1988, the Centers for Disease Control and the Oklahoma State Department of Health identified 40 patients who had a fourfold or greater change in antibody titer in response to<i>Ehrlichia canis</i>. The median age of these patients was 42 years, 83% were male, 76% became ill between May and July, and 92% reported recent exposures to ticks. Patients resided in or were exposed to ticks in 14 states, including five where ehrlichiosis had not been reported before 1988. Thirty-four patients (85%) were hospitalized, and many had serious complications, including acute respiratory failure (seven patients), encephalopathy (six patients), and acute renal failure (four patients). Pulmonary infiltrates were demonstrated in 14 patients, cerebrospinal fluid pleocytosis was seen in 10 patients, and elevated levels of serum creatinine were demonstrated in eight patients. Two patients, both of whom had preexisting medical problems, died. Nonhospitalized patients received tetracycline therapy earlier in the course of their illness than hospitalized patients. There was no significant difference in the interval from initiation of antibiotic therapy to the first day of defervescence between patients treated with tetracyclines and those treated with chloramphenicol. (<i>JAMA</i>. 1990;264:2251-2258)
IMPACT OF CHRONIC KIDNEY DISEASE AND ANEMIA ON 5-YEAR MORTALITY AFTER ACUTE MYOCARDIAL INFARCTION
Authors: Kazuoki Dai, Masaharu Ishihara, Ichiro Inoue, Takuji Kawagoe, Yuji Shimatani, Satoshi Kurisu, Yasuharu Nakama, Eisuke Kagawa, Takayuki Otani, Hiroki Ikenaga, Yoshimasa Morimoto, Kentaro Ejiri, Nozomu Oda
Journal: Journal of the American College of Cardiology (2010)
THE FUTURE OF THE VOLUNTARY HOSPITAL AND ITS RELATION TO A REFORMED POOR-LAW MEDICAL SERVICE
Authors: L. E. Shaw
Journal: BMJ (1908)

HOSPITAI [4 Ja. '471 perhaps, to follow up In this very room during a period of years scores of cases of a similar nature!He has been a sensible fellow, has noS only kept his notes, but has studied them.He has collated his experience, and he can give you advice what to do with that little boy that repays you a thousandfold for any trouble or any expense you may have had in connexion with the hospital.Or
Should Patients With Heart Disease Drink Alcohol?
Authors: Arthur L. Klatsky
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal