Gamma-Interferon for Severe Chronic Active Epstein-Barr Virus
Authors: Tomoaki Fujisaki
Journal: Annals of Internal Medicine (1993)

Letters15 March 1993Gamma-Interferon for Severe Chronic Active Epstein-Barr VirusTomoaki Fujisaki, MD, Seiho Nagafuchi, MD, and Takashi Okamura, MDTomoaki Fujisaki, MD, Seiho Nagafuchi, MD, and Takashi Okamura, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-6-199303150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Severe chronic active Epstein-Barr virus (EBV) infection is often characterized by protracted fever, lymphadenopathy, hepatosplenomegaly, pancytopenia, and extremely high titers of EBV-related antibodies [1]. Life-threatening complications, including pulmonary involvement, have been reported [1, 2]. There is no established treatment, and clinical improvement is rare. We describe a patient with EBV-associated pneumonia, in whom γ-interferon appeared to be effective.A 27-year-old male patient was referred to us because of high fever, pneumonia, severe pancytopenia (hemoglobin, 5.0 g/dL; leukocyte count, 400/mm3; platelet count, 39 000/mm3), hepatosplenomegaly, and generalized lymphadenopathy. Severe chronic active EBV infection was diagnosed on the basis ...References1. Okano M, Matsumoto S, Osato T, et al. Severe chronic active Epstein-Barr virus infection syndrome. Clin Microbiol Rev. 1991; 4:129-35. Google Scholar2. Schooley RT, Carey RW, Miller G, et al. Chronic Epstein-Barr virus infection associated with fever and interstitial pneumonitis. Clinical and serologic features and response to antiviral chemotherapy. Ann Intern Med. 1986; 104:634-6. Google Scholar3. Virelizier JL, Lenoir G, Griscelli C. Persistent Epstein-Barr virus infection in a child with hypergammaglobulinemia and immunoblastic proliferation associated with a selective defect in immune interferon secretion. Lancet. 1978; 2:231-4. Google Scholar4. Hsu D, Malefyt R, Fiorentino D, Dang MN, Viera P, de Vries J, et al. Expression of interleukin-10 activity by Epstein-Barr virus protein BCRFI. Science. 1990; 250:830-2. Google Scholar5. Okano M, Thiele GM, Kobayashi RH, et al. Interferon-γ in a family with X-linked lymphoproliferative syndrome with acute Epstein-Barr virus infection. J Clin Immunol. 1989; 9:48-54. Google Scholar Author, Article, and Disclosure InformationAuthors: Tomoaki Fujisaki, MD; Seiho Nagafuchi, MD; Takashi Okamura, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPerspective Chapter: The Role of Interferon Gamma in Clinical MedicineRecombinant Human Interferon-Gamma: Prospects for the Treatment of Chronic Epstein-Barr Viral InfectionDynamics of endogenous interferon-alpha and -gamma production under the influence of ingaron therapy in patients with chronic epstein – barr viral infection with chronic fatigue syndromeThe effect of ingaron on the dynamics of copies of deoxyribonucleic acid Epstein - Barr virus in saliva samples and on the manifestation of clinicalINFLUENCE OF INGARON ON THE DYNAMICS OF INTERFERON-α AND -γ PRODUCTION AND ON THE MANIFESTATION OF CLINICAL SYMPTOMS IN PATIENTS WITH CHRONIC VIRUS EРSTHTEIN-BARR INFECTIONOptimal treatment for chronic active Epstein-Barr virus diseaseEPSTEIN-BARR VIRUSEpstein–Barr Virus Infections (Mononucleosis and Lymphoproliferative Disorders)Overview and problematic standpoints of severe chronic active Epstein–Barr virus infection syndromeTherapeutic Approaches for Severe Epstein-Barr Virus InfectionEpstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alphaEpstein–Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alphaEpstein-Barr-Virusinfektionen 15 March 1993Volume 118, Issue 6Page: 474-475KeywordsAntibodiesAntifungalsAntigensCellsEpstein-Barr virusFeversNatural killer cellsPlateletsPneumoniaThorax ePublished: 15 August 2000 Issue Published: 15 March 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...