tbuckley/cabot-search huggingface dataset:
Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey
Authors: Mareen R. Datema, Laurian Zuidmeer-Jongejan, Riccardo Asero, Laura Barreales, Simona Belohlavkova, Frédéric de Blay, Peter Bures, Michael Clausen, Ruta Dubakiene, David Gislason, Monika Jedrzejczak-Czechowicz, Marek L. Kowalski, André C. Knulst, Tanya Kralimarkova, Thuy-My Le, Alison Lovegrove, Justin Marsh, Nikolaos G. Papadopoulos, Todor Popov, Náyade del Prado, Ashok Purohit, Gerald Reese, Isabel Reig, Suranjith L. Seneviratne, Athanasios Sinaniotis, Serge A. Versteeg, Stefan Vieths, Aeilko H. Zwinderman, Clare Mills, Jonas Lidholm, Karin Hoffmann-Sommergruber, Montserrat Fernández-Rivas, Barbara Ballmer-Weber, Ronald van Ree
Journal: Journal of Allergy and Clinical Immunology (2015)
Johns Hopkins Health System agrees to pay $190m to women filmed by doctor during pelvic exams
Authors: M. McCarthy
Journal: BMJ (2014)

The Johns Hopkins Health System in Baltimore, Maryland, has agreed to pay $190m (£111m; €141m) to settle a lawsuit brought by thousands of women who were secretly filmed and photographed by a doctor during their pelvic examinations.

The lawsuit alleged that Nikita A Levy, an obstetrician gynecologist who practiced at Johns Hopkins for 25 years, had surreptitiously filmed and photographed women during gynecological examinations using a pen-like camera strapped around his neck. Levy was fired by the hospital system in February 2013 …
Acanthrocytes and Schistocytes After Cardiopulmonary Bypass.
Authors: Richard V. Smalley
Journal: Annals of Internal Medicine (1969)

s1 May 1969Acanthrocytes and Schistocytes After Cardiopulmonary Bypass.Richard V. Smalley, M.D., Felix M. Cortes, M.D., F.A.C.P.Richard V. Smalley, M.D.Search for more papers by this author, Felix M. Cortes, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1086_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe significance of acanthrocytes and red cell fragmentation was evaluated in 31 patients undergoing cardiopulmonary bypass. Seven patients served as controls, and 24 patients with valvular prosthesis were observed for a period of at least 2 weeks. In the control group minimal red cell fragmentation (2-3/10 hpf) was seen, while acanthrocytes were present only during and immediately after cardiopulmonary bypass. In seven patients with valvular replacement the results were similar to the control group. Six other patients showed increased red cell fragmentation (15/10 hpf). In three of these, red cell fragmentation disappeared by the third postoperative week, in two by... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Richard V. Smalley, M.D.; Felix M. Cortes, M.D., F.A.C.P.Affiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1086-1086KeywordsCardiopulmonary bypass ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia
Authors: Serena Y. Tan, Julie Rosenthal, Xiao-Qing Zhao, Richard J. Francis, Bishwanath Chatterjee, Steven L. Sabol, Kaari L. Linask, Luciann Bracero, Patricia S. Connelly, Mathew P. Daniels, Qing Yu, Heymut Omran, Linda Leatherbury, Cecilia W. Lo
Journal: Journal of Clinical Investigation (2007)

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder associated with ciliary defects and situs inversus totalis, the complete mirror image reversal of internal organ situs (positioning). A variable incidence of heterotaxy, or irregular organ situs, also has been reported in PCD patients, but it is not known whether this is elicited by the PCD-causing genetic lesion. We studied a mouse model of PCD with a recessive mutation in Dnahc5, a dynein gene commonly mutated in PCD. Analysis of homozygous mutant embryos from 18 litters yielded 25% with normal organ situs, 35% with situs inversus totalis, and 40% with heterotaxy. Embryos with heterotaxy had complex structural heart defects that included discordant atrioventricular and ventricular outflow situs and atrial/pulmonary isomerisms. Variable combinations of a distinct set of cardiovascular anomalies were observed, including superior-inferior ventricles, great artery alignment defects, and interrupted inferior vena cava with azygos continuation. The surprisingly high incidence of heterotaxy led us to evaluate the diagnosis of PCD. PCD was confirmed by EM, which revealed missing outer dynein arms in the respiratory cilia. Ciliary dyskinesia was observed by videomicroscopy. These findings show that Dnahc5 is required for the specification of left-right asymmetry and suggest that the PCD-causing Dnahc5 mutation may also be associated with heterotaxy.
Blinding and exclusions after allocation in randomised controlled trials: survey of published parallel group trials in obstetrics and gynaecology
Authors: K. F Schulz, D. A Grimes, D. G Altman, R. J Hayes
Journal: BMJ (1996)

To assess the methodological quality of approaches to blind ing and to handling of exclusions as reported in randomised trials from one medical specialty.Survey of published, parallel group randomised controlled trials.A random sample of 110 reports in which allocation was described as randomised from 1990 and 1991 volumes of four journals of obstetrics and gynaecology.The adequacy of the descriptions of double blinding and exclusions after randomisation.Through 31 trials reported being double blind, about twice as many could have been. Of the 31 trials only eight (26%) provided information on the protection of the allocation schedule and only five (16%) provided some written assurance of successful implementation of double blinding. Of 38 trials in which the authors provided sufficient information for readers to infer that no exclusions after randomisation had occurred, six (16%) reported adequate allocation concealment and none stated that an intention to treat analysis had been performed. That compared with 14 (27%) and six (12%), respectively, for the 52 trials that reported exclusions.Investigators could have double blinded more often. When they did double blind, they reported poorly and rarely evaluated it. Paradoxically, trials that reported exclusions seemed generally of a higher methodological standard than those that had no apparent exclusions. Exclusions from analysis may have been made in some of the trials in which no exclusions were reported. Editors and readers of reports of randomised trials should understand that flawed reporting of exclusions may often provide a misleading impression of the quality of the trial.
Patients and the Habits of House Officers
Authors: Lawrence S. Neinstein
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The article by Dunn et al<sup>1</sup>entitled "Patient and House Officer Attitudes on Physician Attire and Etiquette" was interesting in that there are few studies that have examined the impact of physician dress style. However, this survey examined only the preferences of patients and did not examine the subsequent effect of dress style on patient-physician rapport. This question has been examined, at least in an adolescent population, in a study we conducted recently.<sup>2</sup>In our study, physicians randomly dressed in four dress styles from jeans to suit and tie. At the end of the interview, patients were asked to fill out a confidential questionnaire on their comfort level with their physician and also their preferences about the dress of their physician. Regardless of the dress style of the physician, the patients evaluated their physicians equally. In this study, 43% of the respondents stated that dress
Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury
Authors: V A J Maria, R M M Victorino
Journal: Gut (1997)

Background —Diagnosis of drug induced liver injury is usually based on a temporal relation between drug intake and clinical picture as well as on the exclusion of alternative causes. More precise diagnosis has been attempted by using in vitro specific T cell reactivity to drugs but the test has never reached general acceptability because of frequent negative results which could be explained, in part, by prostaglandin producing suppressor cells (PPSC). Aim —To analyse the diagnostic value of a modified test where lymphocyte responses to drugs are detected in the presence of a prostaglandin inhibitor. Patients —Ninety five patients with a clinical diagnosis of drug induced liver injury, 106 healthy controls, 35 individuals with recent exposure to the same drugs without adverse effects, and 15 patients with liver disease unrelated to drugs. Methods —Peripheral blood mononuclear cells (PBMC) were cultured in the presence of drugs alone and in the presence of drugs and a prostaglandin inhibitor. Responses were assessed by 3 H-thymidine incorporation in lymphocytes. Results were expressed as counts per minute and as stimulation indexes (SI). Results —When PBMC were stimulated with drugs alone, lymphocyte sensitisation to drugs (SI&gt;2) was detected in 26% of the cases. This was noticeably increased (56%) when a prostaglandin inhibitor was added to the cultures. No reactivity was found in controls. In patients with possible sensitivity to several drugs, lymphocyte reactivity was detected to only one drug. The severity of the lesions, as assessed by aminotransferase concentrations and disease duration, was lower in patients with evidence of PPSC. Conclusions —This new approach is useful for the diagnosis of drug induced liver injury, particularly in patients exposed to more than one drug; furthermore, the presence of putative PPSC is associated with less severe forms of drug induced hepatitis.
IMPACT OF SMOKING STATUS ON CLINICAL OUTCOMES AFTER SUCCESSFUL CHRONIC TOTAL OCCLUSION INTERVENTION: KOREAN MULTICENTER CTO REGISTRY
Authors: Min-Ho Lee, Chang-Hwan Yoon, Jin-Ju Park, Myung-Jin Cha, Sang-Don Park, Il-Young Oh, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, Dong-Ju Choi, In-Ho Chae
Journal: Journal of the American College of Cardiology (2013)
20 Common Problems in Primary Care
Authors: Michael B. Steinberg
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes15 June 199920 Common Problems in Primary CareMichael B. Steinberg, MD, MPHMichael B. Steinberg, MD, MPHJefferson Medical College, Philadelphia, Pennsylvania. (Steinberg)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Weiss BD; ed. 592 pages. New York: McGraw-Hill; 1999. $45.00. ISBN 0070696098. Order phone 800-262-4729.Field of medicine: Primary care.Format: Softcover book.Audience: Practitioners, residents, and students in primary care.Purpose: To introduce a new series on the background, diagnoses, and management of the most common problems seen in primary care.Content: The book reviews 20 of the most common conditions seen by primary care practitioners. These problems are grouped into categories, such as “the major killers” (smoking, obesity, hypertension, and diabetes), “aches and pains” (chest and abdominal pain, arthritis, back pain, and headache), and organ systems (respiratory and ... Author, Article, and Disclosure InformationAffiliations: Jefferson Medical College, Philadelphia, Pennsylvania. (Steinberg) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1999Volume 130, Issue 12Page: 1031KeywordsAbdominal painDomestic violenceLiteracyLower back painObesityPainPsychologyRespiratory systemSigns and symptomsThorax ePublished: 15 August 2000 Issue Published: 15 June 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Relatives keener on euthanasia than patients
Authors: L Dillner
Journal: BMJ (1994)

People in Britain are more likely to request euthanasia to avoid being a burden to their relatives than because they are in pain, according to a new study. Clive Seale, a lecturer in the sociology of medicine at Goldsmith's College, London, and Julia Addington-Hall, an epidemiologist from University College London, asked 2192 people who had recently been bereaved about their experiences. They were asked whether the dying person had expressed a wish to die earlier and whether he or she had requested euthanasia.

Relatives were asked whether the person would have benefited from an earlier death. Over …
Brief Communication: Sirolimus-Associated Pneumonitis: 24 Cases in Renal Transplant Recipients
Authors: Laure Champion, Marc Stern, Dominique Israël-Biet, Marie-France Mamzer-Bruneel, Marie-Noëlle Peraldi, Henri Kreis, Raphaël Porcher, Emmanuel Morelon
Journal: Annals of Internal Medicine (2006)

Background: Interstitial pneumonitis is an ill-defined side effect of sirolimus, a new immunosuppressant drug recently introduced for patients having organ transplantation. Objective: To evaluate clinical and laboratory features of sirolimus-associated pneumonitis. Design: Case series. Setting: 1 transplantation center in Paris, France. Patients: 24 patients who had renal transplantation and developed sirolimus-associated pneumonitis, including 8 patients previously reported. Measurements: Symptoms; laboratory tests, including bronchoalveolar fluid analysis; and computed tomography (CT) of the chest. Intervention: Withdrawal or dose reduction of sirolimus. Results: Clinical symptoms included cough (23 patients), fatigue (20 patients), fever (16 patients), and dyspnea (8 patients). Computed tomography of the chest showed reticular and ground-glass opacities (4 patients), bronchiolitis obliterans–organizing pneumonia (19 patients), and lobar consolidation (1 patient). Bronchoalveolar lavage showed lymphocytic (19 patients) or eosinophilic (3 patients) alveolitis or pulmonary hemorrhage (2 patients). A reduction in the sirolimus dose resulted in transient clinical improvement in 2 patients, but discontinuation of drug therapy was eventually necessary in all patients. All patients recovered completely within 6 months. Limitations: The sirolimus trough level in patients from this single center was higher than that usually used in patients having renal transplantation. Conclusion: Lymphocytic alveolitis and radiologic bronchiolitis obliterans–organizing pneumonia are the key findings in sirolimus-associated pneumonitis. Sirolimus withdrawal was associated with recovery within 6 months.
Increasing the uptake of cervical smear testing among Asian women.
Authors: J M Carter, S E Ellerby
Journal: BMJ (1991)

improve "academic achievement."Supportive evidence for the effectiveness of treatment in definite cases of hypothyroidism was later pro- vided.5Neonatal screening for hypothyroidism is now widely accepted because hormonal supplementation prevents adverse physical and neurological sequelae of the disorder.We have postulated that intrauterine hypothyroidism of early onset may result in irreversible brain damage and be one of the underlying causes of mental handicap in infants with chromosomal abnormalities.If this is the case short term intrauterine hormone supplementation during a critical stage of develop- ment may reduce impaired neurological development.
THE SPECIFIC ANTIGENS OF VARIANTS OF SHIGELLA SONNEI
Authors: Edgar E. Baker, Walther F. Goebel, Ely Perlman
Journal: The Journal of Experimental Medicine (1949)

It has been shown that phase variation of Sh. sonnei is accompanied by changes in morphology and antigenic structure. Two mutants of the Phase I organism (IIS and IIR), which were studied, elaborate somatic antigens which are immunologically identical. The purified lipocarbohydrate-protein antigens of the Phase I and IIS microorganisms are chemically similar yet immunologically distinct and specific. By inference the same should hold true of the antigen of IIR, but it has not yet been investigated in this relation. It is suggested that when Sh. sonnei undergoes variation from Phase I to IIS the immunological changes occurring are dependent upon a change in the enzyme systems responsible for the synthesis of the lipocarbohydrate-protein constituent.
Thymus epithelium induces tissue-specific tolerance.
Authors: A Bonomo, P Matzinger
Journal: The Journal of Experimental Medicine (1993)

Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize antigens expressed by thymic epithelium, that the tolerance is tissue specific, and that it can occur by deletion of the reactive T cells.
THE LIMITATIONS OF MEDICINE.
Authors: FRANK BILLINGS
Journal: JAMA (1898)

Medicine has for its object the relief of suffering and the prolongation of life. There exist many limitations to the successful accomplishment of this object. The limitations of medicine are less numerous today than in the past, and many of the obstacles to success in the prevention of disease and the healing of the sick will be removed in the future. Medicine as a whole is not a science. Of some branches which enter into it our knowledge is exact; of others our information is theoretic, while every day adds to our knowledge and removes many obstacles from the path of progress. The chemic laboratory and the microscope have done much and will do more to make medicine a science. Progress in knowledge of chemistry and biology has been wonderful in the last twenty years, and this knowledge has removed many of the limitations of medicine. Strange as it may
Practical Observations on the Treatment of the Purulent Ophthalmia of Infants
Authors: J. C. Wordsworth
Journal: BMJ (1863)

led to a trial of the latter from observing an improved circulation in the chloroid, after its performance in cases where the pupil had been partially obstructed from the effects of ani irido-clhoroiditis.tMr.Dixon's experience lhas led him to the conclusion that some instances of acute glauicoma recover after a paracentesis of the corniea (Wardrop's operation)-a fact admitted by Griife; wlhile otlhers require, for perma- nent reduction of teDsioni, a more compound operation, namely, the removal of a small bit of iris.(Holmes's Surgery, vol.ii, p. 85,-.)
A STUDY IN NON-RESTRAINT
Authors: M. G. JACOBY, H. BABIKIAN, E. MCLAMB, B. HOHLBEIN
Journal: American Journal of Psychiatry (1958)

When a program of non-restraint is put into action both personnel and patients require re-training. In a period of 6 weeks all physical restraints have been abolished on a disturbed service. The patients are much more relaxed and the personnel take a much greater interest in their work. Abolition of restraint has been attained without any increase or change in personnel. Noisy and aggressive patients have shown a much better response to the new regimen than those who are regressed and deteriorated. Although the program has been in effect for only a short time, our convalescent rate is already 9 times what it was in the previous year. We have attempted to prove the truth of the statement of Dr. John Connolly, a hundred years ago: "Restraint and neglect are synonymous. They are a substitute for the thousand attentions needed by a disturbed patient."
Primary prevention of coronary heart disease
Authors: P. Brindle
Journal: BMJ (2002)

Papers p 78

Population screening for individuals at high risk of getting coronary heart disease is an explicit objective in primary care. The national service framework for coronary heart disease recommends that general practitioners and primary healthcare teams should identify all people at significant risk of cardiovascular disease, but who have not yet developed symptoms, and offer them appropriate advice and treatment to reduce their risk.1 In contrast to the current policy of maximising participation, Marteau and Kinmonth in this issue suggest that helping individuals to become involved in making informed choices may increase their motivation to make changes.2

When the introduction of a national screening programme is being considered, a proper scientific evaluation should occur. Wilson and Jungner's criteria are a yardstick against which a screening programme can be judged (see box).3 Apart from the recognition that coronary heart disease is an important health problem little evidence exists that any of the other criteria are adequately met.

The “significant risk of …
Flagella on Legionnaires' Disease Bacteria
Authors: FRANCIS W. CHANDLER
Journal: Annals of Internal Medicine (1980)

Scanning and transmission electron microscopic studies were done on five strains of flagellated Legionella pneumophila cultured for 1 to 3 days on charcoal yeast extract agar or yeast extract broth. Ultrastructurally, each strain consisted of pleomorphic, flagellated bacilli, many of which showed the typical pinching type of division as seen with other gram-negative bacteria. Most of the flagellated organisms, regardless of the strain, had a single, relatively straight or undulant polar flagellum, about 25 nm in diameter. In some instances, retraction of the bacterial cell membranes made the flagellar basal bodies (bulbs) visible when observed by transmission electron microscopy. The bulbous nature of these bodies appears to be different from the basal structures described for Escherichia coli and other gram-negative bacteria. Long "streamers," previously observed with the light microscope, appear to be fimbriae (or pili) that have a diameter approximatley half that of the flagella and are somewhat coiled and bent at irregular intervals.
Comparison of Bare-Metal Stenting With Minimally Invasive Bypass Surgery for Stenosis of the Left Anterior Descending Coronary Artery
Authors: Holger Thiele, Stefan Oettel, Stephan Jacobs, Rainer Hambrecht, Peter Sick, Jan F. Gummert, Friedrich W. Mohr, Gerhard Schuler, Volkmar Falk
Journal: Circulation (2005)

Background— Randomized trials comparing stenting with minimally invasive direct coronary artery bypass surgery in patients with isolated proximal left anterior descending lesions have shown a significantly higher reintervention rate for stenting and similar results for mortality and reinfarction at short-term follow-up. Long-term follow-up data are sparse. Methods and Results— Patients with isolated proximal left anterior descending stenosis were randomized to either surgery (n=110) or bare-metal stenting (n=110). At 5 years, follow-up data were obtained with respect to the primary end point of death, reinfarction, or repeated target vessel revascularization. Clinical symptoms were assessed by the Canadian Cardiovascular Society (CCS) classification. Follow-up information was completed for 216 patients (98.2%), and mean follow-up was 5.6±1.2 years. With respect to mortality (surgery, 12%; stenting, 10%; P =0.54) and reinfarctions (surgery, 7%; stenting, 5%; P =0.46), there were no differences between treatment strategies. The need for repeated target vessel revascularization was significantly higher after stenting (32%) compared with surgery (10%; P &lt;0.001). Clinical symptoms improved significantly in both treatment groups compared with baseline; however, there was a favorable trend for surgery (stenting: CCS, 2.6±0.9 to 0.5±0.8, P &lt;0.001; surgery: CCS, 2.6±0.9 to 0.3±0.6, P &lt;0.001; P =0.05, stenting versus surgery). Conclusions— At the 5-year follow-up, minimally invasive bypass surgery and bare-metal stenting showed similar results for the end points of mortality and reinfarctions. However, the reintervention rate is higher after stenting, and the relief in clinical symptoms is slightly better after surgery.