β-Blocker-Induced Quadriparesis
Authors: Hassane Izzedine, Vincent Launay-Vacher, Jean Sebastien Hulot, Damien Sternberg, Gilbert Deray
Journal: Annals of Internal Medicine (2004)

Letters17 August 2004β-Blocker-Induced QuadriparesisHassane Izzedine, MD, Vincent Launay-Vacher, PharmD, Jean Sebastien Hulot, MD, Damien Sternberg, MD, and Gilbert Deray, MDHassane Izzedine, MDFrom Hôpital Pitié-Salpêtrière, 75013 Paris, France.Search for more papers by this author, Vincent Launay-Vacher, PharmDFrom Hôpital Pitié-Salpêtrière, 75013 Paris, France.Search for more papers by this author, Jean Sebastien Hulot, MDFrom Hôpital Pitié-Salpêtrière, 75013 Paris, France.Search for more papers by this author, Damien Sternberg, MDFrom Hôpital Pitié-Salpêtrière, 75013 Paris, France.Search for more papers by this author, and Gilbert Deray, MDFrom Hôpital Pitié-Salpêtrière, 75013 Paris, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-4-200408170-00028-w1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background and Objective: Acute quadriplegic myopathy (AQM) may manifest when corticosteroids and neuromuscular blocking agents are coadministered. We report what we believe to be the first case of β-blocker–induced AQM.Case Report: A 56-year-old male anephric patient who was undergoing hemodialysis was admitted because of weakness in his legs and forearms. His medications included bisoprolol, 2.5 mg/d, and atorvastatin, 10 mg/d. His blood pressure was 100/60 mm Hg, his body temperature was 36.8 °C, his heart rate was 80 beats/min, and his respiratory rate was 20 breaths/min. He described difficulties standing up and getting up off the ...References1. Zimlichman R, Krauss S, Paran E. Muscle cramps induced by beta-blockers with intrinsic sympathomimetic activity properties: a hint of a possible mechanism [Letter]. Arch Intern Med. 1991;151:1021. [PMID: 2025129] CrossrefMedlineGoogle Scholar2. Rich MM, Pinter MJ. Sodium channel inactivation in an animal model of acute quadriplegic myopathy. Ann Neurol. 2001;50:26-33. [PMID: 11456306] CrossrefMedlineGoogle Scholar3. Kajiwara K, Yanagita T, Nakashima Y, Wada A, Izumi F, Yanagihara N. Differential effects of short and prolonged exposure to carvedilol on voltage-dependent Na(+) channels in cultured bovine adrenal medullary cells. J Pharmacol Exp Ther. 2002;302:212-8. [PMID: 12065719] CrossrefMedlineGoogle Scholar4. Ptacek LJ, Trimmer JS, Agnew WS, Roberts JW, Petajan JH, Leppert M. Paramyotonia congenita and hyperkalemic periodic paralysis map to the same sodium-channel gene locus. Am J Hum Genet. 1991;49:851-4. [PMID: 1654742] MedlineGoogle Scholar5. Fontaine B, Vale-Santos J, Jurkat-Rott K, Reboul J, Plassart E, Rime CS, et al . Mapping of the hypokalaemic periodic paralysis (HypoPP) locus to chromosome 1q31-32 in three European families. Nat Genet. 1994;6:267-72. [PMID: 8012389] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hôpital Pitié-Salpêtrière, 75013 Paris, France. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatitis C Infection and Thyrotoxic Periodic Paralysis—A Novel Use of an Old DrugTenofovir-Associated Renal Problems: Hyperphosphatemia from OTC Bowel Preparations: Beta-Blocker Induced Quadriparesis: Two Adverse Reactions in the Same (Unlucky) Patient: Warfarin-Associated Hemorrhage: Benzodiazepines and Hip Fractures 17 August 2004Volume 141, Issue 4Page: W-62KeywordsAttentionDrugsMusclesMutationParalysisPotassiumSerum glutamic oxaloacetic transaminaseSkeletal musclesSodium channelsStatins ePublished: 17 August 2004 Issue Published: 17 August 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...