tbuckley/cabot-search huggingface dataset:
Effect of direct current countershock on atrial and ventricular electrophysiological properties and myocardial potassium efflux in the thoracotomised dog
Authors: M. F. ARNSDORF, D. A. ROTHBAUM, R. W. CHILDERS
Journal: Cardiovascular Research (1977)

Journal Article Effect of direct current countershock on atrial and ventricular electrophysiological properties and myocardial potassium efflux in the thoracotomised dog Get access M. F. ARNSDORF, M. F. ARNSDORF 2 From the Section of Cardiology, Department of Medicine, The Pritzker School of Medicine, The University of Chicago 2Address for correspondence and reprints: Dr Morton F. Arnsdorf, Department of Medicine (Cardiology), The University of Chicago, 950 East 59th Street, Box 249, Chicago, Illinois 60637, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar D. A. ROTHBAUM, D. A. ROTHBAUM From the Section of Cardiology, Department of Medicine, The Pritzker School of Medicine, The University of Chicago Search for other works by this author on: Oxford Academic PubMed Google Scholar R. W. CHILDERS R. W. CHILDERS From the Section of Cardiology, Department of Medicine, The Pritzker School of Medicine, The University of Chicago Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 11, Issue 4, July 1977, Pages 324–333, https://doi.org/10.1093/cvr/11.4.324 Published: 01 July 1977
Endoscopic Percutaneous Gastrostomy without Laparotomy
Authors: K. Hashiba, C.E. Fabbri, C.A. Cappellanes, P.D. Branco, D. Birolini, M.R. Oliveira
Journal: Endoscopy (1984)

Observation and manipulation through the endofiberscope, have resulted in a new method of establishing gastrostomy without laparotomy. Subsequent to experimental studies with dogs, the new method was employed to substitute nasogastric tube in patients. In this new procedure, endoscopic application permits the placing of stitches in close contact with the abdominal and gastric walls. The fact that no complications were observed in the patients submitted to operative treatment, is largely attributed to this type of suture. From the results obtained it would seem that this procedure can be routinely employed instead of gastrostomy with laparotomy, since it offers the advantage of being a simpler method and is more likely to be associated with a lower rate of complications.
Todd-Sanford Clinical Diagnosis by Laboratory Methods
Authors: John B. Fuller
Journal: JAMA (1974)

This, the 15th edition of<i>Todd and Sanford</i>, is the second edited by Israel Davidsohn and John Bernard Henry. Davidsohn and Henry had expanded the scope of the book, previously limited, by obtaining authors whose chapters have covered almost all areas of laboratory medicine. This new edition maintains the place of this book as the best reference in modern laboratory medicine. The book as a whole is a compendium of methodologies, but each chapter provides good discussion of basic mechanisms, clinical relevance, and the basis for clinical interpretations of the laboratory tests. It will be particularly useful to residents and laboratory directors who can read it prior to their consultations with the clinicians. It will be useful to clinicians to provide the basis for their clinical interpretations. Students of medicine and technology will generally find it too lengthy and detailed for everyday use but will find it a useful reference.
TCT-730 Hospitalization Costs Of Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: Comparison Between Clopidogrel And Prasugrel Patients In A US Hospital Database
Authors: Jay Bae, Frank Ernst, Douglas Faries, Craig Lipkin, Chad Moretz, Zhenxiang Zhao
Journal: Journal of the American College of Cardiology (2012)
Induction of Anesthesia with Methohexital and Thiopental in Electroconvulsive Therapy
Authors: Ferris N. Pitts, Gilles M. Desmarais, Wendell Stewart, Kevin Schaberg
Journal: New England Journal of Medicine (1965)

ELECTROCONVULSIVE therapy has become an important psychiatric treatment since its introduction into clinical practice in 1938 by Cerletti and Bini.1 , 2 There is evidence that it is superior to antidepressant drugs as symptomatic therapy for severe depressions.3 , 4 The chief cause of morbidity before the introduction of drug modification of the seizure was frequent vertebral compression fracture.5 , 6 The chief cause of mortality in both drug-modified and unmodified electroconvulsive therapy has been cardiovascular complication.7 8 9 10 Deaths are infrequent (0.01 per cent of treatments), may occur in any age or cardiovascular-risk group and have probably increased in frequency with the use of drug modification.5 , 9 , 10 Using . . .
Multidimensional Rhythm Disturbances as a Precursor of Sustained Ventricular Tachyarrhythmias
Authors: Vladimir Shusterman, Benhur Aysin, Kelley P. Anderson, Anna Beigel
Journal: Circulation Research (2001)

Abstract —Cardiac cycle dynamics reflect underlying physiological changes that could predict imminent arrhythmias but are obscured by high complexity, nonstationarity, and large interindividual differences. To overcome these problems, we developed an adaptive technique, referred to as the modified Karhunen-Loeve transform (MKLT), that identifies an individual characteristic (“core”) pattern of cardiac cycles and then tracks the changes in the pattern by projecting the signal onto characteristic eigenvectors. We hypothesized that disturbances in the core pattern, indicating progressive destabilization of cardiac rhythm, would predict the onset of spontaneous sustained ventricular tachyarrhythmias (VTAs) better than previously reported methods. We analyzed serial ambulatory ECGs recorded in 57 patients at the time of VTA and non-VTA 24-hour periods. The disturbances in the pattern were found in 82% of the recordings before the onset of impending VTA, and their dimensionality, defined as the number of unstable orthogonal projections, increased gradually several hours before the onset. MKLT provided greater sensitivity and specificity (70% and 93%) compared with the best traditional method (68% and 67%, respectively). We present a theoretical analysis of MKLT and describe the effects of ectopy and slow changes in cardiac cycles on the disturbances in the pattern. We conclude that MKLT provides greater predictive accuracy than previously reported methods. The improvement is due to the use of individual patterns as a reference for tracking the changes. Because this approach is independent of the group reference values or the underlying clinical context, it should have substantial potential for predicting other forms of arrhythmic events in other populations.
Physician Assistants and Nurse Practitioners
Authors: Jane Maffie-Lee
Journal: Annals of Internal Medicine (1995)

Letters1 August 1995Physician Assistants and Nurse PractitionersJane Maffie-Lee, Christine Cadegan, and Margerie GeronomoJane Maffie-LeeSearch for more papers by this author, Christine CadeganSearch for more papers by this author, and Margerie GeronomoSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-3-199508010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We are writing in response to the American College of Physicians' recent position paper on the role of physician assistants and nurse practitioners [1]. As registered nurses studying to become nurse practitioners, we represent a growing force of providers who will be prepared to provide primary care to many persons in all stages of life. It is important to clarify some misleading issues described in the College's position paper.In the paper, the educational preparation of the nurse practitioner was compared with that of the physician assistant. It is noted that nurse practitioners spend 9 to 24 ...REFERENCE1. American College of Physicians. Physician assistants and nurse practitioners. Ann Intern Med. 1994; 121:714-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Jane Maffie-Lee; Christine Cadegan; Margerie Geronomo PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1995Volume 123, Issue 3Page: 237-238KeywordsCommunication in health careHealth careHealth care qualityNursesNursing educationPrimary careResearch fundingUndergraduates ePublished: 15 August 2000 Issue Published: 1 August 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Mortality after the Treatment of Hyperthyroidism with Radioactive Iodine
Authors: J.A. Franklyn, P. Maisonneuve, M.C. Sheppard, J. Betteridge, P. Boyle
Journal: New England Journal of Medicine (1998)

Hyperthyroidism affects many organ systems, but the effects are usually considered reversible. The long-term effects of hyperthyroidism on mortality are not known.
Developing a Rational Tumor Vaccine Therapy for Renal Cell Carcinoma: Immune Yin and Yang
Authors: Marc S. Ernstoff, Todd S. Crocenzi, John D. Seigne, Nancy A. Crosby, Bernard F. Cole, Jan L. Fisher, Jill C. Uhlenhake, Diane Mellinger, Cathy Foster, Conrad J. Farnham, Kathleen Mackay, Zbigniew M. Szczepiorkowski, Susan M. Webber, Alan R. Schned, Robert D. Harris, Richard J. Barth, John A. Heaney, Randolph J. Noelle
Journal: Clinical Cancer Research (2007)

In patients with progressive malignancy, the natural balance between proinflammatory (Yang) and inhibitory (regulatory or Yin) immune pathways is disrupted and favors cancer-specific immune suppression. Therapy with interleukin 2 (IL-2) can mobilize immune effector cells that recognize and destroy cancer. High-dose IL-2 is the only therapy that has consistently induced complete durable remissions in patients with metastatic renal cell carcinoma (RCC) but only in a few of them. The lack of benefit in most metastatic RCC patients is likely due to the ineffective manipulation of other immune circuits critical in regulating tumor cytotoxic pathways. The limited clinical activity of IL-2, RCC vaccines, and other immune therapies to date leads us to postulate that effective clinical treatment strategies will need to simultaneously enhance proinflammatory pathways and disrupt regulatory pathways. We present preliminary studies in RCC patients to highlight the complexity of the regulatory pathways and our approach to shifting the balance of proinflammatory and regulatory immune pathways using dendritic cell-tumor lysate vaccine followed by cytokine therapy.
Abstract 4478: Discovery of AZD5363, an orally bioavailable, potent ATP-competitive inhibitor of AKT kinases
Authors: Richard W. Luke, Matthew Addie, Matthew R. Box, David Buttar, Claire Crafter, Gordon S. Currie, Sabina C. Cosulich, Barry Davies, Philippa G. Dudley, Ryan Greenwood, Paul D. Johnson, Hannah Greenwood, Gillian M. Lamont, Clare Lane, Ken M. Page, Stuart E. Pearson, Linette Ruston
Journal: Cancer Research (2011)

Abstract AKT is a key node in the most frequently de-regulated signaling pathway in human cancer and has been shown to mediate resistance to a range of cytotoxic, anti-hormonal and targeted therapies. We decided to explore inhibitors of AKT as potential new anti-cancer therapeutics. Here we disclose for the first time the discovery and structure of AZD5363, an orally bioavailable, potent ATP-competitive inhibitor of AKT. We evaluated a range of chemical starting points arising from our previous collaboration with the Institute of Cancer Research and Astex Therapeutics Ltd. Ultimately AZD5363 was discovered following a long journey that started from a pyrrolopyrimidine series of compounds. Our first challenge was to improve potency and a second challenge was to improve ROCK selectivity. ROCK is an AGC kinase like AKT but is involved in regulation of vascular tone and thus blood pressure. Extensive SAR studies exploring the series revealed that achieving selectivity over ROCK while retaining AKT potency was quite challenging. Eventually we discovered ways which could improve both selectivity and potency. However, these compounds had significant activity against the hERG ion channel which is implicated in the development of Torsades de Pointes and cardiac death. The next phase of work therefore had to focus on reducing hERG activity, while at the same time not adversely impacting either AKT potency or ROCK selectivity. Finally we discovered that introduction of a key substituent group provided a compound that achieved reduced hERG potency and, surprisingly, also achieved a further small improvement in both AKT potency and ROCK selectivity. This compound was AZD5363. A crystal structure of AZD5363 bound to AKT has revealed some of the key interactions that may contribute to its potency. For example, the pyrrolopyrimidine appears to form hydrogen bonds to the hinge region of the kinase. AZD5363 inhibits all known AKT isoforms with a potency of &amp;lt;10 nM and inhibits phosphorylation of the AKT substrate, PRAS40 in BT474c cells with a potency of 0.31 μM. Activity in in vivo pharmacodynamic and xenograft models has also been demonstrated. A synthetic route suitable for scale-up has been developed. In conclusion, AZD5363 is a potent inhibitor of AKT in vitro and in cells. It has good hERG and ROCK selectivity. It has pharmacodynamic and xenograft activity in vivo. AZD5363 has potential in cancer therapy and is currently in phase 1 clinical trials. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4478. doi:10.1158/1538-7445.AM2011-4478
Abstract 903: Long-term survivors in advanced non-small cell lung cancer
Authors: Satoru Fujiuchi, Yuka Fujita, Yutaka Nishigaki, Kyoko Nakanishi, Yasushi Yamamoto, Akinori Takeda, Yasuhiro Yamazaki, Toshiaki Fujikane
Journal: Cancer Research (2010)

Abstract Background: It is known that chemotherapy for advanced non small-cell lung cancer (NSCLC) improves the prognosis, however, with regard to 2-year survival rate of inoperable stage III/IV patients is up to 20%. The contribution of chemotherapies for survival is not fully satisfied yet. Purpose: The aim of this study is to evaluate the rate of long-term survival of more than 2 years in patients with advanced NSCLC and elucidate clinical factors that affect long-term survival in those patients. Methods: We retrospectively reviewed 103 patients with inoperable, stage III/IV NSCLC treated with chemotherapy from January 2005 to December 2006 at Dohoku National Hospital. These included 69 adenocarcinomas, 22 squamous cell carcinomas, 9 large cell carcinomas and 3 others. These patients were divided into two groups: those who survived more than 2 years (long-term survivors; LTS) and the others (non long-term survivors; non LTS). We analyzed the prognostic factors that affect the survival in this setting. The difference of characteristics between two groups was tested with the Mann-Whitney U test, the chi-square test or Fisher's exact test. Survival curves were calculated according to Kaplan-Meier method. The correlations of variables with survival were analyzed by multivariate analysis using a Cox proportional hazards model. Results: There were 27 (26.2%) patients who survived more than 2 years (LTS). All of them had performance status (PS) 0 or 1. These LTS included 13 females, 11 non-smoker, 21 adenocarcinomas and 17 stage IV disease. LTS showed significant correlation with gender, smoking status, intrapulmonary metastases, response of 1st-line chemotherapy (SD or better), and response of gefitinib (SD or better) (p=0.0008, p=0.0457, p=0.0317, p=0.0004 and p=0.0026, respectively). Patients who respond to initial chemotherapy (SD or better) as well as gefitinib showed favorable course. Univariate analyses showed that PS 0-1, intrapulmonary metastases, response of 1st-line chemotherapy (SD or better), response of gefitinib (SD or better) were significantly associated with better prognosis (p=0.0036, p=0.0203, p&amp;lt;0.0001 and p=0.0090, respectively). Multivariate analyses showed absence of bone metastases, response of 1st-line chemotherapy (SD or better), response of gefitinib (SD or better) were significantly associated with good prognosis (p=0.0031, p&amp;lt;0.0001 and p=0.0028, respectively). Conclusions: Absence of bone metastases, response of 1st-line chemotherapy and response of gefitinib are the significant factors to predict better prognosis in patients with advanced non-small cell lung cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 903.
Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients
Authors: Shohei Nakanishi, Junichiro James Kazama, Tomoko Nii-Kono, Kentaro Omori, Takeyoshi Yamashita, Seiji Fukumoto, Fumitake Gejyo, Takashi Shigematsu, Masafumi Fukagawa
Journal: Kidney International (2005)
Hemodialysis and Infection.
Authors: Robert M. Blankenship
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Hemodialysis and Infection.Robert M. Blankenship, M.D.Robert M. Blankenship, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-825_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAdvances in the management of renal failure necessitate a new look at the uremic patient. Infection is the leading cause of death in acute renal failure and the second most common cause of death in chronic uremia. The uremic patient must be regarded as an altered host more susceptible to infection. Some contributing factors are alterations of the skin and mucous membrane barriers, as well as lymphocyte and leukocyte dysfunction. Lymphocytes produce less interferon and also, when stimulated by phytohemagglutinin, show decreased metabolic activity in uremic serums. Leukocyte Chemotaxis is decreased. Other factors await more scientific investigation. Another important source... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dallas, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByStaphylococcus Aureus Bacteremia in Hemodialysis Patients 1 May 1973Volume 78, Issue 5Page: 825-825KeywordsAcute renal failureChemotaxisInterferonsLymphocytesMucous membranesPhytohemagglutininsRenal failure Issue Published: 1 May 1973 PDF DownloadLoading ...
Gene Therapy With Extracellular Superoxide Dismutase Attenuates Myocardial Stunning in Conscious Rabbits
Authors: Qianhong Li, Roberto Bolli, Yumin Qiu, Xian-Liang Tang, Sidney S. Murphree, Brent A. French
Journal: Circulation (1998)

Background —Administration of Cu/Zn superoxide dismutase (SOD) without catalase fails to alleviate myocardial stunning, but extracellular SOD (Ec-SOD) may be more effective because it binds to heparan sulfate proteoglycans on the cellular glycocalyx. We therefore used in vivo gene transfer to increase systemic levels of Ec-SOD and determined whether this gene therapy protects against myocardial stunning. Methods and Results —The cDNA for human Ec-SOD was cloned behind the cytomegalovirus (CMV) promoter and incorporated into a replication-deficient adenovirus (Ad5/CMV/Ec-SOD). Injection of this virus (2×10 8 pfu/kg IV) produced high levels of Ec-SOD in the liver, which could be redistributed to the heart and other organs by injection of heparin. Conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion cycles for 3 consecutive days starting 3 days after intravenous injection of Ad5/CMV/Ec-SOD or Ad5/CMV/nls/LacZ (negative control). Both groups were given heparin (2000 U/kg IV) 2 hours before the first sequence of occlusions. The severity of myocardial stunning was measured as the total deficit of LV wall thickening after the last reperfusion. On day 1, the total deficit of wall thickening was markedly decreased in Ad5/CMV/Ec-SOD rabbits versus controls and similar to that seen on days 2 and 3 in controls. Conclusions —The results demonstrate that in vivo gene transfer of the cDNA encoding Ec-SOD provides the heart with substantial protection against myocardial stunning without the need for concomitant administration of catalase. The present observations provide the basis for controlling gene therapy at the posttranslational level and for simultaneously protecting multiple organs from oxidant stress.
Naltrexone Extended-Release Plus Bupropion Extended-Release for Treatment of Obesity
Authors: Susan Z. Yanovski, Jack A. Yanovski
Journal: JAMA (2015)

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