Methotrexate Therapy in Cutaneous Sarcoidosis
Authors: Guy F. Webster, Linda K. Razsi, Miguel Sanchez, Jerome R. Shupack
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 September 1989Methotrexate Therapy in Cutaneous SarcoidosisGuy F. Webster, MD, PhD, Linda K. Razsi, MD, Miguel Sanchez, MD, Jerome R. Shupack, MDGuy F. Webster, MD, PhDSearch for more papers by this author, Linda K. Razsi, MDSearch for more papers by this author, Miguel Sanchez, MDSearch for more papers by this author, Jerome R. Shupack, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-538 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Methotrexate, a commonly used antimetabolite in cancer chemotherapy, has also been used to treat various nonmalignant diseases including rheumatoid arthritis, inflammatory bowel disease, asthma, and graft-versus-host disease, as well as skin diseases such as psoriasis and those seen in the Reiter syndrome (1, 2). Adverse reactions to methotrexate are occasionally seen, but less frequently than with other equally potent drugs (1-3).We report the results of a trial of methotrexate therapy in three patients with refractory cutaneous sarcoidosis. Skin disease was long-standing and widespread, involving the trunk and extremities. Two patients had debilitating ulcerations, and two patients...References1. TugwellBennettBellGent PKMM. Methotrexate in rheumatoid arthritis. Feedback on American College of Physicians guidelines. Ann Intern Med. 1989;110:581-3. LinkGoogle Scholar2. RoenigkAuerbachMaibachWeinstein HRHG. Methotrexate in psoriasis: revised guidelines. J Am Acad Derm. 1988;19:146-56. CrossrefGoogle Scholar3. ShupackWebster JG. Pancytopenia following low dose oral methotrexate therapy for psoriasis. J Am Med Assoc. 1988;259:3594-6. CrossrefGoogle Scholar4. Lachner M. Spontaneous remission or response to methotrexate in sarcoidosis. Ann Intern Med. 1968;69:1247-8. LinkGoogle Scholar5. VeienBrodthagen NH. Treatment of sarcoid with methotrexate. Br J Derm. 1977;97:213-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMethotrexateThe spectrum of nephrocutaneous diseases and associationsCutaneous SarcoidosisMultinational evidence-based World Association of Sarcoidosis and Other Granulomatous Disorders recommendations for the use of methotrexate in sarcoidosisMethotrexate use in rheumatoid arthritis. A clinician's perspectiveImmunosuppressive Agents in Skin DisordersMethotrexate with leucovorin rescue: A therapeutic alternative in severe psoriatics with a history of methotrexate-induced pancytopenia and diminished renal or hepatic functionThe pharmacology of methotrexateLow-dose weekly methotrexate for unusual neutrophilic vascular reactions: Cutaneous polyarteritis nodosa and Behçeťs disease 15 September 1989Volume 111, Issue 6Page: 538-539KeywordsAdverse reactionsCancer chemotherapyInflammatory bowel diseaseMethotrexatePsoriasisReactive arthritisRheumatoid arthritisSarcoidosisSkin diseasesUlcers Issue Published: 15 September 1989 PDF DownloadLoading ...