tbuckley/cabot-search huggingface dataset:
Simvastatin-induced amyopathic dermatomyositis
Authors: O. Inhoff, W.K. Peitsch, B.E. Paredes, S. Goerdt, M. Goebeler
Journal: British Journal of Dermatology (2009)

Journal Article Simvastatin‐induced amyopathic dermatomyositis Get access O. Inhoff, O. Inhoff Department of Dermatology, University Hospital Mannheim, University of Heidelberg, 68135 Mannheim, Germany Search for other works by this author on: Oxford Academic Google Scholar W.K. Peitsch, W.K. Peitsch Department of Dermatology, University Hospital Mannheim, University of Heidelberg, 68135 Mannheim, Germany Search for other works by this author on: Oxford Academic Google Scholar B.E. Paredes, B.E. Paredes Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany Search for other works by this author on: Oxford Academic Google Scholar S. Goerdt, S. Goerdt Department of Dermatology, University Hospital Mannheim, University of Heidelberg, 68135 Mannheim, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Goebeler M. Goebeler Department of Dermatology, University Hospital Mannheim, University of Heidelberg, 68135 Mannheim, Germany Correspondence: Matthias Goebeler (Current address: Department of Dermatology, University Hospital Giessen, University of Giessen, 35385 Giessen, Germany) E‐mail: matthias.goebeler@derma.med.uni‐giessen.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 161, Issue 1, 1 July 2009, Pages 206–208, https://doi.org/10.1111/j.1365-2133.2009.09205.x Published: 01 July 2009
SOCS3 is an endogenous inhibitor of pathologic angiogenesis
Authors: Andreas Stahl, Jean-Sebastian Joyal, Jing Chen, Przemyslaw Sapieha, Aimee M. Juan, Colman J. Hatton, Dorothy T. Pei, Christian G. Hurst, Molly R. Seaward, Nathan M. Krah, Roberta J. Dennison, Emily R. Greene, Elisa Boscolo, Dipak Panigrahy, Lois E. H. Smith
Journal: Blood (2012)
Tc-99m Albumin Scintigraphy in the Localization of Protein Loss in the Gut
Authors: REGI OOMMEN, GEORGE KURIEN, N BALAKRISHNAN, S NARASIMHAN
Journal: Clinical Nuclear Medicine (1992)

Scintigraphic localization of gastrointestinal protein loss has been recently reported. A noninvasive method for the localization of protein loss in the gut using Tc-99m labeled albumin seems encouraging and is described here. In six patients studied for protein-losing enteropathy, scintigraphic results of four were positive.
EIS Officers: Medical Detectives
Authors: Marsha F. Goldsmith
Journal: JAMA (1990)

WHEN LISTERIOSIS struck the neonatal unit in a Costa Rican hospital about a year ago, the CDC sent Anne Schuckit, MD, to find out why. The young Epidemic Intelligence Service (EIS) officer had investigated one other major outbreak at the time, but it offered little direct guidance for how to approach the new problem. Yet she knew what to do, and no more infants in that hospital became ill. Tackling outbreaks of diseases as diverse as Schuckit's first encounter with a rapidly transmitted pathogen—which turned out to be sporotrichosis, a fungal infection—and her second, the<i>Listeria</i>bacterium, is par for the EIS course. Founding the EIS in 1951, Alexander Langmuir, MD, set up a 2-year training and service program designed to accomplish three objectives: (1) to help the CDC implement its mission to prevent and control communicable diseases, (2) to increase the number of field-trained epidemiologists in the United States,
Long-term Outpatient Anticoagulation Therapy
Authors: James J. Nora
Journal: JAMA (1960)

Results of treatment with anticoagulants were studied in 60 persons with disease of the coronary arteries. Among 26 patients, during a period when they were not receiving anticoagulants, there were 14 myocardial infarctions. Five patients from this group were then added to a group of 34 patients receiving long-term anticoagulant therapy. The maintenance dose of warfarin sodium ranged from 15 to 140 mg. per week, divided into daily doses. The aim was to keep the patient's prothrombin time between 25 and 35 seconds. Among the 39 patients so treated there were no infarctions during the period of treatment. These observations showed not only that anticoagulant therapy reduced the probability of myocardial infarction in these patients but also that it can be carried out, along with the necessary prothrombin time determinations, as part of regular office practice.
The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Authors: Thomas O'Hare, Matthew S. Zabriskie, Christopher A. Eide, Anupriya Agarwal, Lauren T. Adrian, Huihong You, Amie S. Corbin, Fei Yang, Richard D. Press, Victor M. Rivera, Julie Toplin, Stephane Wong, Michael W. Deininger, Brian J. Druker
Journal: Blood (2011)
TCT-375 Optimizing Rotational Atherectomy in High-Risk Percutaneous Coronary Interventions. Insights from the PROTECT II study
Authors: Mauricio Cohen, Abhijit Ghatak, Neal Kleiman, Srihari Naidu, E. Magnus Ohman, Igor Palacios, Alan Heldman, William O'Neill
Journal: Journal of the American College of Cardiology (2012)
Abstract 5130: Functional role of the crosstalk between arginine methylation and phosphorylation of hnRNPK during DNA damage
Authors: Jen-Hao Yang
Journal: Cancer Research (2014)

Abstract HnRNPK is an RNA/DNA binding protein participating in chromatin remolding, RNA processing and DNA damage response. In addition, elevation of hnRNPK has been associated with tumor development and progression. Moreover, hnRNPK is known as co-transcription factor of p53 to regulate cell cycle arrest and apoptosis upon DNA damage. A variety of post-translational modifications of hnRNPK has been identified and shown to regulate its function, including phosphorylation, ubiquitination, sumoylation and methylation. However, the functional significance of hnRNPK arginine methylation remains unclear. In this study, we characterize the function of two essential arginine methylation of hnRNPK and demonstrate that they are able to inhibit the nearby PKCδ phosphorylation. Since PKCδ is a pro-apoptotic kinase upon DNA damage, we further investigate whether these essential arginine methylations of hnRNPK participate in the regulation of cell apoptosis. Citation Format: Jen-Hao Yang. Functional role of the crosstalk between arginine methylation and phosphorylation of hnRNPK during DNA damage. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5130. doi:10.1158/1538-7445.AM2014-5130
Implementation of the Fifth Link of the Chain of Survival Concept for Out-of-Hospital Cardiac Arrest
Authors: Takashi Tagami, Kazuhiko Hirata, Toshiyuki Takeshige, Junichiroh Matsui, Makoto Takinami, Masataka Satake, Shuichi Satake, Tokuo Yui, Kunihiro Itabashi, Toshio Sakata, Ryoichi Tosa, Shigeki Kushimoto, Hiroyuki Yokota, Hisao Hirama
Journal: Circulation (2012)

The American Heart Association 2010 resuscitation guidelines recommended adding a fifth link (multidisciplinary postresuscitation care in a regional center) to the previous 4 in the chain of survival concept for out-of-hospital cardiac arrest. Our study aimed to determine the effectiveness of this fifth link.This multicenter prospective cohort study involved all eligible out-of-hospital cardiac arrest patients in the Aizu region (n=1482, suburban/rural, Fukushima, Japan). Proportions of favorable neurological outcomes were evaluated before (January 2006-April 2008) and after (January 2009-December 2010) the implementation of the fifth link. After implementation, all patients were transported directly from the field to the tertiary-level hospital or secondarily from an outlying hospital to the tertiary-level hospital after restoration of circulation. The tertiary hospital provided intensive postresuscitation care, including appropriate hemodynamic and respiratory management, therapeutic hypothermia, and percutaneous coronary intervention. One-month survival with a favorable neurological outcome among all patients treated by emergency medical services providers improved significantly after implementation (4 of 770 [0.5%] versus 21 of 712 [3.0%]; P<0.001). The adjusted odds ratios of favorable neurological outcome were 0.9 (95% confidence interval, 0.7-1.1) for early access to emergency medical care, 3.1 (95% confidence interval, 0.7-14.2) for bystander resuscitation, 14.7 (95% confidence interval, 3.2-67.0) for early defibrillation, 1.0 (95% confidence interval, 1.0-1.1) for early advanced life support, and 7.8 (95% confidence interval, 1.6-39.0) for the fifth link.The proportion of out-of-hospital cardiac arrest patients with a favorable neurological outcome improved significantly after the implementation of the fifth link, which may be an independent predictor of outcome.URL: http://www.apps.who.int/trialsearch. Unique identifier: UMIN000001607.
Abstract P2-05-17: Correlation between cyclin D1, estrogen and progesterone receptors in invasive breast cancer after short-term treatment with tamoxifen or anastrozole
Authors: EC Millen, A Mattar, AF Logullo, S Nonogaki, FA Soares, LH Gebrim
Journal: Cancer Research (2012)

Abstract INTRODUCTION: Hormone therapy is associated with reduced breast cancer mortality. The use of biomarkers that are predictive of early cellular responses has been explored as a predictor of hormone resistance. Estrogen and progesterone receptor positivity and cyclin D1 have been associated with resistance to treatment with tamoxifen. OBJECTIVES: The aim of this study was to investigate the variations in the levels of cyclin D1 and the estrogen and progesterone receptors (ER and PR, respectively) in postmenopausal patients with ER− or PR-positive breast cancer after short-term treatment (26 days) with tamoxifen, anastrozole or a placebo. METHODS: This was a prospective, randomized double-blind study conducted in 71 patients with infiltrating ductal carcinoma (stages II and III) receiving care at either Pérola Byington Hospital or São Paulo Hospital (São Paulo, Brazil). The patients were divided into three groups based on their treatment during the preoperative period (26 days): P (placebo, N = 26), T (tamoxifen, 20 mg/day, N = 22) and A (anastrozole, 1 mg/day, N = 23). The biopsies were performed at diagnosis and after mastectomy (26th day), and the tumors were isolated by tissue microarray. Immunohistochemistry was performed using anti-cyclin D1 (Novocastra DCS-6), anti-ER (Dako-M7047) and anti-PR (Dako-M3569) antibodies. The semiquantitative analyses were performed using Allred criteria, and the statistical analyses were performed with the ANOVA parametric test (p ≤ 0.05). RESULTS: A reduction in the mean PR level from 4.22 (pre-treatment) to 1.94 (post-treatment) was observed only in patients treated with anastrozole (p = 0.01). A positive linear correlation between cyclin D1 and PR levels was observed in group A (p = 0.0001), whereas group T exhibited a negative correlation (p = 0.0001). No correlation was observed in group P (p = 0.35). CONCLUSION: PR and cyclin D1 are likely predictive of an early response to aromatase inhibitors in breast cancer. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-05-17.
From crying to words: Unique or multilevel selective pressures?
Authors: Daniela Lenti Boero, Luciana Bottoni
Journal: Behavioral and Brain Sciences (2006)

In the first year of life, infants' utterances change from high-intensity crying to low-intensity acoustic sound strings, acoustically labelling the first word. This transition implies: (1) decoding of phonetic sounds, (2) encoding of phonetic sounds, and (3) a unique linking of an articulated sound to a specific object. Comparative, ontogenetic, and phylogenetic aspects are considered for multilevel selective pressures.
Echo-Lucency of Computerized Ultrasound Images of Carotid Atherosclerotic Plaques Are Associated With Increased Levels of Triglyceride-Rich Lipoproteins as Well as Increased Plaque Lipid Content
Authors: Marie-Louise M. Grønholdt, Børge G. Nordestgaard, Britt M. Wiebe, Jens E. Wilhjelm, Henrik Sillesen
Journal: Circulation (1998)

Background —Echo-lucency of carotid atherosclerotic plaques on computerized ultrasound B-mode images has been associated with a high incidence of brain infarcts as evaluated on CT scans. We tested the hypotheses that triglyceride-rich lipoproteins in the fasting and postprandial state predict carotid plaque echo-lucency and that echo-lucency predicts a high plaque lipid content. Methods and Results —The study included 137 patients with neurological symptoms and ≥50% stenosis of the relevant carotid artery. High-resolution B-mode ultrasound images of carotid plaques were computer processed to yield a measure of echogenicity (gray-scale level). Lipoproteins were measured before and hourly for 4 hours after a standardized fatty meal. A subgroup of 58 patients underwent endarterectomy. On linear regression analysis, echo-lucency (low gray-scale level) was associated with elevated levels of fasting and postprandial plasma triglycerides ( P =.0002 and P =.002), IDL cholesterol ( P =.0009 and P =.006), and VLDL/chylomicron remnant cholesterol ( P =.0003 and P =.0004) and triglycerides ( P =.0003 and P =.003), the area under the plasma triglyceride curve 0 to 4 hours after a fatty meal ( P =.001), and body mass index ( P =.0001). On ANCOVA, body mass index, fasting IDL cholesterol, and fasting plasma triglycerides were independent predictors of echo-lucency. Echo-lucency was associated with increased relative plaque lipid content ( P =.02). Conclusions —Increased plasma levels of triglyceride-rich lipoproteins predict echo-lucency of carotid plaques, which is associated with increased plaque lipid content. Because echo-lucency has been associated with a high incidence of brain infarcts on CT scans, triglyceride-rich lipoproteins may predict a plaque type particularly vulnerable to rupture.
397 Enhanced angiopoietin-2 expression in liver tissue of hepatitis B virus (HBV) infected patients is mediated by HBV X protein (HBx)
Authors: P. Sanz-Cameno, S. Martin-Vilchez, M.J. Borque, J.A. Moreno-Monteagudo, M. López-Cabrera, R. Moreno-Otero
Journal: Journal of Hepatology (2006)
<i>BRAF</i>V600E Mutation and Papillary Thyroid Cancer—In Reply
Authors: Anne R. Cappola, Susan J. Mandel
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology and outcomes of bloodstream infection in patients with cirrhosis
Authors: Michele Bartoletti, Maddalena Giannella, Paolo Caraceni, Marco Domenicali, Simone Ambretti, Sara Tedeschi, Gabriella Verucchi, Lorenzo Badia, Russell E. Lewis, Mauro Bernardi, Pierluigi Viale
Journal: Journal of Hepatology (2014)
Suction drainage: a new approach to the treatment of empyema.
Authors: A R Cummin, N L Wright, A E Joseph
Journal: Thorax (1991)

Thirteen patients with empyema thoracis were treated with a new suction drainage technique. The method entails passing a catheter into the empyema cavity under ultrasound guidance and using strong suction to drain loculated pus. Eight patients had no recurrence after a single treatment and one patient had no recurrence after two treatments. The procedure was a useful palliative measure in two patients with malignant disease who subsequently died. In one patient failure of the lung to expand after the procedure showed the need for thoracotomy. In one other patient the empyema recurred and decortication was required.
Ichthyosis, photosensitivity and pseudoerythrodontia
Authors: B.V Reddy, U.P. Lakshmi, B.S.N. Reddy
Journal: British Journal of Dermatology (2008)

Journal Article Ichthyosis, photosensitivity and pseudoerythrodontia Get access B.V Reddy, B.V Reddy Skin & VD Center, Hyderabad (A.P.), India E‐mail: drviswanathreddy@gmail.com Search for other works by this author on: Oxford Academic Google Scholar U.P. Lakshmi, U.P. Lakshmi Mamata Medical College and General Hospital, Khammam (A.P.), India Search for other works by this author on: Oxford Academic Google Scholar B.S.N. Reddy B.S.N. Reddy Mamata Medical College and General Hospital, Khammam (A.P.), India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 4, 1 October 2008, Pages 979–981, https://doi.org/10.1111/j.1365-2133.2008.08751.x Published: 01 October 2008
Digoxin Metabolism in the Elderly
Authors: GORDON A. EWY, GEETA G. KAPADIA, LINDA YAO, MURIEL LULLIN, FRANK I. MARCUS
Journal: Circulation (1969)

Tritiated digoxin (0.5 mg) was given intravenously to five elderly men (mean age, 77 years) and nine young men (mean age, 27 years). The elderly were not in congestive heart failure. The serum creatinines of the old and young were not different. However, the creatinine clearance averaged 56 ml/min/1.73 m 2 in the old and 122 ml/min/1.73 m 2 in the young ( P &lt;0.001). Digoxin clearance averaged 53 ml/min/1.73 m 2 in the old and 83 ml/min/1.73 m 2 in the young ( P &lt;0.001). The blood concentrations of tritiated digoxin were significantly higher in the elderly throughout the study ( P &lt;0.05). When blood digoxin concentrations were corrected for body surface area, there was no significant difference between the two groups during the first 24 hr, but thereafter the concentrations in the elderly were higher. The same dose of digoxin resulted in higher blood concentrations and longer blood half-life in the elderly. This is due to the smaller body size and a diminished urinary excretion of digoxin in the elderly.
Tri-functional T cell receptor antigen coupler (Tri-TAC): a novel method to direct T cells against tumors
Authors: Christopher Helsen, Ben Li, Galina Denisova, Jonathan L Bramson
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Engineering T cells with chimeric antigen receptors (CARs) is proving to be an effective method for directing T cells to attack tumors in an MHC-independent manner. Current generation CARs aim to recapitulate T cell signaling by incorporating modular functional components of the
LUDWIG'S ANGINA AND MEDIASTINAL ABSCESS FOLLOWING TONSILLECTOMY; OPERATION; RECOVERY
Authors: Carl M. Sautter
Journal: JAMA (1926)

Much has happened in the last fifty years to further the progress of tonsil surgery and to stimulate the interest in medical history. After a fairly thorough search of the literature from 1890 to 1922, I am convinced that mediastinal abscess is a very rare terminal complication following a tonsillectomy. In a review made for me four years ago by the American Institute of Medicine, forty-one mediastinal histories were given, none of which ascribed the original source of infection to the tonsils. Fifteen of these cases were traumatic, occurring during the late war, due to bullet, grenade or stab wounds. Forty per cent of these were fatal, death occurring as the result of collapse, pulmonary sepsis, a rupture into the pericardium and great absorption from the rich lymphatic supply. Loeb, in his exhaustive study of fatal complications following tonsillectomy, fails to mention this one. Glogau, in his article on phlegmonous
Focal Activity in Early Phase Scan Should Not Be Ignored
Authors: Julia Cortes, Edurne Ruiz-Gopegui, Juan I. Alonso, Gabriel Basterra, Soledad Alvarez, Pilar Alcorta
Journal: Clinical Nuclear Medicine (2008)

A 63-year-old man was hospitalized for recurrent painless gastrointestinal bleeding. Panendoscopy, double-balloon enteroscopy, and wireless capsule endoscopy showed no abnormal findings. A Tc-99m pertechnetate scan was performed to detect a Meckel diverticulum. The scintigraphy showed an abnormal vascular blush in the angiographic phase at the abdomen close to the left common iliac artery. Mesenteric arteriography showed a hypervascular mass over the left lower quadrant of the abdomen. Histologic examination confirmed a gastrointestinal stromal tumor (GIST).
Ablation of human colon carcinoma in nude mice by 131I-labeled monoclonal anti-carcinoembryonic antigen antibody F(ab')2 fragments.
Authors: F Buchegger, C Pfister, K Fournier, F Prevel, M Schreyer, S Carrel, J P Mach
Journal: Journal of Clinical Investigation (1989)

Pooled F(ab')2 fragments of three MAbs against distinct epitopes of carcinoembryonic antigen (CEA) were used for radioimmunotherapy of nude mice bearing a subcutaneous human colon carcinoma xenograft. 9-10 d after transplantation when tumor nodules were in exponential growth, 36 mice were treated by intravenous injection of different amounts of 131I-labeled MAb F(ab')2. All 14 mice injected with a single dose of 2,200 (n = 10) or 2,800 microCi (n = 4) showed complete tumor remission. 8 of the 10 mice treated with 2,200 microCi survived in good health for 1 yr when they were killed and shown to be tumor free. Four of nine other mice treated with four fractionated doses of 400 microCi showed no tumor relapse for more than 9 mo. In contrast, all 15 mice injected with 1,600-3,000 microCi 131I-control IgG F(ab')2 showed tumor growth retardation of only 1-4 wk, and 15 of 16 mice injected with unlabeled anti-CEA MAb F(ab')2 showed unmodified tumor progression as compared with untreated mice. From tissue radioactivity distributions it was calculated that by an injection of 2,200 microCi 131I-MAb F(ab')2 a mean dose of 8,335 rad was selectively delivered to the tumor, while the tissue-absorbed radiation doses for the normal organs were: peripheral blood, 2,093; stomach, 1,668; kidney, 1,289; lung, 1,185; liver, 617; spleen, 501; small intestine, 427; large intestine, 367; bone, 337; and muscle, 198. These treatments were well tolerated since out of 19 mice with complete tumor remission only 4 required bone marrow transplantation and 17 were in good health for 6-12 mo of observation. The results demonstrate the selective destruction of established human colon carcinoma transplants by intravenous injection of either single or fractionated doses of 131I-MAb F(ab')2.