tbuckley/cabot-search huggingface dataset:
TCT-787 A Prospective Study of the Contemporary Role of Balloon Aortic Valvuloplasty in the Management of Patients with Severe Aortic Stenosis
Authors: Molly C. Mack, Molly Szerlip, Morley Herbert, J.M. DiMaio, Michael Mack, Elizabeth M. Holper
Journal: Journal of the American College of Cardiology (2014)
Atlas of Hernia Repair
Authors: Leo M. Zimmerman
Journal: JAMA (1967)

There are numerous good current monographs on hernia, and the periodical literature is replete with excellent articles from authoritative sources dealing with all aspects of this subject. In view of this wealth of available material, one wonders why the publishers would bring out a book on hernia that is totally lacking in merit. True, they have produced a very attractive volume with a beautiful binding, fine glossy stock, and pleasing format, but beyond this nothing favorable can be added.  The text of this book is brief, superficial, and inaccurate. The arrangement of the material is illogical. The selection is poor and the information offered is familiar to all. The book purports to be an atlas, but the illustrations are for the most part small diagrammatic line drawings, often of postage stamp size. None but the neophyte might have use for a book such as this, but this one cannot even
Basal cell carcinoma: histological classification and body-site distribution
Authors: B.A. Raasch, P.G. Buettner, C. Garbe
Journal: British Journal of Dermatology (2006)

Background Basal cell carcinoma (BCC) is the most common cancer worldwide in white‐skinned populations. Recent studies suggest that BCC is not a single entity and that different histological subtypes show different clinical behaviour and might have different aetiology. Objectives To provide information on the incidence of BCC by histopathological subtype and body site. Methods A case series of BCC from a prospective population‐based register study collecting information on all excised and histologically confirmed skin cancers in Townsville, north Australia between 1997 and 1999. Results Age‐standardized incidence rates for nodular BCC were 727·1 per 100 000 inhabitants per year for males and 411·8 for females, while rates for superficial BCC were 336·5 for males and 251·4 for females. Incidence rates for 'high risk' BCC were 261·3 for males, 146·5 for females with infiltrative, and 156·7 for males and 100·2 for females with micronodular types. Superficial BCC occurred at a younger age, particularly in female patients. For all histological subtypes and both genders relative tumour density was highest for the face, followed by the neck. An exception was superficial BCC in males, where the posterior trunk was second, followed by the neck. Conclusions The study found a higher rate of superficial BCC than previous studies from less sun‐exposed countries, and a more equal distribution of superficial BCC on face, trunk and limbs. These results seem to blur the difference between intermittent and continuous sun exposure as the causative environmental agents. The clinical implications of 'high risk' BCC rates are discussed.
Butchers' warts: no evidence for person to person transmission of HPV7
Authors: M. KEEFE, A. AL-GHAMDI, D. COGGON, N.J. MAITLAND, P. EGGER, C.J. KEEFE, A. CAREY, C.M. SANDERS
Journal: British Journal of Dermatology (1994)

The distribution of warts due to HPV7 in workers in six abattoirs and 103 retail and wholesale butcheries has been studied to determine whether the high prevalence of HPV7 in the meat trade is the result of enhanced person to person transmission, or whether it is a ubiquitous virus which is activated by an unknown factor in meat. Warts were detected in 164 of 486 men. Scrapings were taken from 156 men, and HPV DNA was found in 112 samples, 74 of which contained HPV7. HPV7 was found in 36 workplaces, and there was no evidence of clustering of cases, as would be expected if person to person transmission was occurring in the workplace. This suggests that HPV7 is widely distributed in the community, but only causes clinical disease under specific conditions. We suggest that some unknown factor in meat enhances viral replication.
Dangers of Hypnosis
Authors: Edith Klemperer
Journal: JAMA (1965)

ABSTRACT To the Editor:— In the article, Dangers of Hypnosis, West and Deckert (JAMA192:9-13 [April 5] 1965) catalogue pitfalls in the use of hypnosis. Since adequate statistical analysis does not exist which compares length, effectiveness, dangers, and drawbacks of psychotherapies, it is necessary to wonder why these psychiatrists limit their warnings to the use of hypnosis.Almost every accredited psychotherapist would admit that many or all of the dangerous specters enumerated by West and Deckert exist in his own school, and that continuous application of the forces of training and experience is needed to keep them at bay. Every school of psychotherapy knows that results range between the extremes of complete relief and exacerbation of the psychiatric disorder. Recurrences of symptoms are legion to physical and psychiatric disorders, and precipitation of crises is no novelty. Every type of psychotherapy has had to survive ridicule and accusations of failure.Having
NICE reiterates that people with mild Alzheimer's disease should not get drug treatment
Authors: C. Dyer
Journal: BMJ (2009)

The hopes of people with mild Alzheimer’s disease have been dashed again by the agency that appraises treatments for use by the NHS in England and Wales, which has reaffirmed its original decision to deny them treatment with dementia drugs.

The National Institute for Health and Clinical Excellence (NICE) has issued amended guidance but still asserts that the drugs would not be cost effective for the mild stages of the disease.

The original guidance from NICE was challenged by Eisai, the UK licence holder for donepezil (Aricept), one of the class of acetylcholinesterase inhibitors affected.

The Court …
The determinants of pulmonary diffusing capacity in a national sample of U.S. adults.
Authors: L M Neas, J Schwartz
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Racial and gender differences in single-breath pulmonary diffusing capacity for carbon monoxide (DLCO) have previously received little attention. Between 1971 and 1975, the first National Health and Nutrition Examination Survey determined DLCO for 4,439 adults ages 25 to 74 residing in the United States, including 2,345 women and 438 blacks. The large sample permitted an evaluation of interactions and nonlinear relationships with DLCO, and its association with biomarkers of inflammation. In a model with separate race, sex, and smoking status intercepts, positive associations with FVC, height, weight, hemoglobin concentration, and negative associations with age and neutrophil count explained 59% of the variation in DLCO. In women, the decline in DLCO with age was much less than in men, but after age 47 the decline with age approached that seen in men. Blacks had lower DLCO levels (-1.96 ml/min/mm Hg, 95% confidence interval [CI] -0.77 to -3.14) with or without adjustment for FVC, but the changes in DLCO with age and height were similar in both races. Former smokers had lower DLCO (-1.13 ml/min/mm Hg, 95% CI -1.57 to -0.69), but this reduction was fully explained by the number of pack-years smoked. In current smokers, cigarettes per day and pack-years were predictive of DLCO even after control for FVC and controlling for these variables fully explained the difference in DLCO between never and current smokers. Peripheral neutrophil count, a biomarker of inflammation, was associated with reduced DLCO. Thus, substantial sex and race differences exist for DLCO within the general United States population.
From methodology to data analysis: Prospects for the n = 1 intrasubject design
Authors: Joseph Glicksohn
Journal: Behavioral and Brain Sciences (2004)

The target article is important not only for black-box studies, but also for those interested in tracing cognitive processing and/or subjective experience (via systematic self-observation). I provide two examples taken from my own research. I then proceed to discuss how best to analyze data from the n = 1 study, which has a factorial design.
Extracellular ATP induces immediate-early gene expression but not cellular hypertrophy in neonatal cardiac myocytes.
Authors: J S Zheng, M O Boluyt, L O'Neill, M T Crow, E G Lakatta
Journal: Circulation Research (1994)

It is well-documented that norepinephrine (NE) induces the expression of immediate-early genes (IEGs), such as c-fos, c-jun, and jun-B, in cultured neonatal heart cells and leads to cell growth without cell division (ie, hypertrophy). Although purinergic receptors activated by ATP are present on cardiac myocytes and ATP is coreleased with NE from sympathetic nerve endings within the heart, the potential role of the purinergic system in the cascade of events that leads to cardiac hypertrophy is unknown. We report in the present study that stimulation of purinergic receptors by micromolar concentrations of extracellular ATP increased the levels of c-fos and jun-B mRNA as well as FOS and JUN-B proteins in neonatal cardiac myocytes. The magnitude of response to micromolar ATP was comparable to that elicited by NE. The increase in IEG expression induced by ATP was preceded by a rapid transient increase in cytosolic Ca2+. Pretreatment of myocytes with the intracellular Ca2+ chelator BAPTA-AM prevented the ATP-stimulated increase in cytosolic Ca2+ and attenuated the ATP-stimulated increase in c-fos expression. In contrast, NE did not increase cytosolic Ca2+ in quiescent myocytes, and pretreatment with BAPTA-AM did not inhibit the NE-stimulated increase in c-fos gene expression. Furthermore, although NE markedly increased [14C]phenylalanine incorporation into protein and myocyte hypertrophy measured by cell size, ATP did not. These results demonstrate that stimulation of purinergic receptors by ATP activates IEGs via a Ca(2+)-dependent pathway in cardiac myocytes that differs from the NE stimulated activation of these genes.(ABSTRACT TRUNCATED AT 250 WORDS)
Methotrexate for the treatment of severe mucocutaneous lupus erythematosus
Authors: W.W. BOTTOMLEY, M. GOODFIELD
Journal: British Journal of Dermatology (1995)

We report three women with severe, chronic mucocutaneous lupus erythematosus who showed a significant improvement during oral methotrexate therapy: the improvement was sustained after the drug was discontinued. Their disease had previously been refractory to a wide range of conventional systemic immunosuppressive therapies. Other treatments were progressively withdrawn, and control was maintained, for a variable length of time, with methotrexate alone, or with a small dose of prednisolone.
Incidence of pulmonary vein complications after lung transplantation: A prospective transesophageal echocardiographic study
Authors: David W. Leibowitz, Craig R. Smith, Robert E. Michler, Mark Ginsburg, Lawrence L. Schulman, Carlton C. McGregor, Giuseppe Li Mandri, Renee G. Weslow, Marco R. Di Tullio, Shunichi Homma
Journal: Journal of the American College of Cardiology (1994)

This study attempted to document the incidence of pulmonary vein complications and their potential relation to clinical outcome in patients after lung transplantation.Several case reports have documented the presence of pulmonary venous thrombosis causing graft failure in patients after lung transplantation. Because the presentation of these complications mimics that of other postoperative problems, the true incidence of pulmonary vein abnormalities remains unclear. Transesophageal echocardiography is ideally suited to examine the pulmonary veins in the postoperative setting.Twenty-one consecutive patients undergoing lung transplantation at our institution underwent transesophageal echocardiography within 32 days of transplantation (mean [+/- SD] 6.5 +/- 7.8 days). Special attention was placed on visualizing the pulmonary veins.Six (29%) of the 21 patients were noted to have abnormalities of the pulmonary veins in the vicinity of the anastomotic site. After follow-up of 30 days, 4 of these patients (67%) had significant cardiovascular morbidity, and 2 died, compared with 1 (7%) of 15 patients with normal pulmonary veins (p = 0.03). The degree of obstruction of the pulmonary vein appeared to correlate with short-term outcome.Abnormalities of the pulmonary veins are common after lung transplantation and are easily identified by transesophageal echocardiography. Occlusive thrombi appear to be detrimental to short-term outcome.
Thrombotic thrombocytopenic purpura: Treatment with plasmapheresis
Authors: Jonathan B. Blitzer, James M. Granfortuna, Arlan J. Gottlieb, J. Robert Smith, Michael E. Theodorakis, Kenneth W. Zamkoff, Stephen A. Landaw, Jack Goldberg, Anthony J. Scalzo, Harold Lamberson
Journal: American Journal of Hematology (1987)

Abstract Twenty‐one episodes of thrombotic thrombocytopenic purpura (TTP) were treated with plasmapheresis. Adjunctive agents included corticosteroids, aspirin, dipyridamole, and vincristine. There were 17 patients; 12 were female. The median age was 41 years. Most patients presented with neurologic symptoms. Thrombocytopenia was profound with a mean initial platelet count of 14,900/mm 3 . The mean hematocrit on presentation was 26.7% and the mean LDH 1300 IU/L. Eighteen episodes responded completely following plasmapheresis/plasma exchange (86%). Response was prompt, the initial rise in platelet count occurred after a mean of four exchanges, and complete response (a platelet count over 150,000/mm 3 ) was obtained after a mean of nine exchanges. Four of the episodes treated were relapses that occurred in three patients. All responders are alive with a median duration of follow‐up of 20 months. The three patients who failed to respond have died. This report extends recent observations that the addition of plasmapheresis/plasma exchange to the therapy of TTP has significantly improved the outlook for patients with this disorder.
Flow cytometric analysis of the ploidy of normoblasts in the peripheral blood of patients with beta‐thalassemia
Authors: Eitan Fibach, Eliezer A. Rachmilewitz
Journal: American Journal of Hematology (1993)

The chronic severe anemia of patients with beta-thalassemia major stimulates extensive erythropoiesis, which results in circulating nucleated normoblasts. We devised a dual staining flow cytometric procedure in order to analyse the cell cycle and ploidy of these normoblasts. Peripheral blood cells of O blood-group type were first stained with Fluorescein Isothiocyanate (FITC)-conjugated anti-H lectin which labels erythroid cells (RBC and normoblasts) by green fluorescence, and then with propidium iodide (PI) which binds to DNA and thereby labels nucleated cells (leukocytes and normoblasts) by red fluorescence. The leukocytes and normoblasts present in the blood sample of thalassemic patients could be distinguished and "gated" based on their green fluorescence. The PI (red) fluorescence, i.e., the DNA histogram of each population, was thus obtained. The results indicated no statistically significant difference in the PI fluorescence of these two populations. Thus, in spite of the abnormal erythropoiesis in beta-thalassemia, the resultant orthochromatic normoblasts are normal with respect to their DNA content.
Congenital Virilizing Adrenal Hyperplasia Without Acceleration of Growth or Bone Maturation
Authors: Thomas Aceto
Journal: JAMA (1966)

The simple form of congenital virilizing adrenal hyperplasia was seen in three girls, aged 21 months to 42 months. These children appear unique because they exhibited very mild virilization of the external genitalia and did not manifest acceleration of bone maturation. Posterior fusion of the labia majora obscured the vaginal orifice, resulting in the appearance of a urogenital sinus formation ("pseudourogenital" sinus). It was found that, until at least 4 years of age, girls untreated for this disorder are usually normal in height. Unless the clinician is aware that normal stature and bone age, and mildly abnormal genitalia, are compatible with congenital virilizing adrenal hyperplasia, patients with this disorder may not be properly treated.
Prediction of successful outcome in 130 patients undergoing percutaneous balloon mitral valvotomy.
Authors: V M Abascal, G T Wilkins, J P O'Shea, C Y Choong, I F Palacios, J D Thomas, E Rosas, J B Newell, P C Block, A E Weyman
Journal: Circulation (1990)

We studied 130 patients undergoing percutaneous balloon mitral valvotomy. The relation between valvular morphology according to a previously described echocardiographic scoring system and hemodynamic outcome expressed as qualitative ("good" and suboptimal) and as absolute change in valve area was analyzed. The relative importance of the individual components of this echocardiographic score (valvular thickening, mobility, calcification, and subvalvular disease) to the change in valve area after valvotomy was also examined. Mean transmitral pressure gradient decreased from 16 +/- 6 to 6 +/- 3 mm Hg (p less than 0.0001), and mitral valve area increased from 0.9 +/- 0.3 to 1.8 +/- 0.7 cm2 (p less than 0.0001). Results in individual patients were variable. Eighty-four percent (61 of 73) of patients with an echocardiographic score of 8 or less had a "good" outcome (final valve area greater than or equal to 1.5 cm2 and an increase in valve area of greater than or equal to 25%), whereas 58% (33 of 57) of patients with an echocardiographic score of 8 or more had a suboptimal result (p less than 0.001). The sensitivity of an echocardiographic score of 8 or less for predicting a "good" outcome was 72%, and the specificity was 73%. The echocardiographic score correlated negatively (r = -0.40, p less than 0.0001) with the absolute increase in mitral valve area after valvotomy, but there was substantial scatter in the data. Of the four components of the total echocardiographic score, valvular thickening correlated best with the absolute change in value area (r = -0.47, p less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand).
Authors: H E Broxmeyer, L Lu, G Hangoc, S Cooper, P C Hendrie, J A Ledbetter, M Xiao, D E Williams, F W Shen
Journal: The Journal of Experimental Medicine (1991)

CD45 antigens are protein tyrosine phosphatases. A possible link was evaluated between expression of CD45 antigens on human myeloid progenitor cells (MPC) (colony-forming unit-granulocyte/macrophage [CFU-GM], burst-forming unit-erythroid [BFU-E], and colony-forming unit-granulocyte/erythroid/macrophage/megakaryocyte [CFU-GEMM]) and regulation of MPC by colony-stimulating factors (CSF) (interleukin 3 [IL-3], GM-CSF, G-CSF, M-CSF, and erythropoietin [Epo]), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (MGF; a c-kit ligand). Treatment of cells with antisense oligodeoxynucleotides (oligos) to exons 1 and 2, but not 4, 5, or 6, of the CD45 gene, or with monoclonal anti-CD45, significantly decreased CFU-GM colony formation stimulated with GM-CSF, IL-3, fusion protein, and GM-CSF + MGF, but not with G-CSF or M-CSF. It also decreased GM-CSF, IL-3, fusion protein, and MGF-enhanced Epo-dependent BFU-E and CFU-GEMM colony formation, but had little or no effect on BFU-E or CFU-GEMM colony formation stimulated by Epo alone. Similar results were obtained with unseparated or purified (greater than or equal to one of two cells being a MPC) bone marrow cells. Sorted populations of CD343+ HLA-DR+ marrow cells composed of 90% MPC were used to demonstrate capping of CD45 after crosslinking protocols. Also, a decreased percent of CD45+ cells and CD45 antigen density was noted after treatment of column-separated CD34+ cells with antisense oligos to exon 1 of the CD45 gene. These results demonstrate that CD45 cell surface antigens are linked to stimulation of early human MPC by IL-3, GM-CSF, a GM-CSF/IL-3 fusion protein, and MGF.
Rapid mobilization of cytotoxic lymphocytes induced by dasatinib therapy
Authors: S Mustjoki, K Auvinen, A Kreutzman, P Rousselot, S Hernesniemi, T Melo, A-M Lahesmaa-Korpinen, S Hautaniemi, S Bouchet, M Molimard, R Smykla, F Y Lee, J Vakkila, S Jalkanen, M Salmi, K Porkka
Journal: Leukemia (2012)
A2.8 Effect of home exercise program in quality of life in patients with ankylosing spondylitis
Authors: Cristina Mesquita, Sofia Lopes, Maria Excelsa Moreira, Patrícia Lopes, Ana Carneiro, Daniela Silva, Inês Neves, Filipa Araújo, Alice Vitorino
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Objectives</h3> Ankylosing spondylitis is a chronic, rheumatic and inflammatory disease with a generally progressive course. The pain and stiffness are the main symptoms that cause the individual less mobility and changes in the sleep cycle producing fatigue, anxiety, stress and depression. This group of symptoms changes the well-being and quality of life of individuals. It is important to follow the recommendations of the physiotherapist about duration and frequency to ensure their effectiveness and improve the quality of life of individuals. The objective of this study is to evaluate the effectiveness of a home-based exercise program in quality of life of people with ankylosing spondylitis. <h3>Material and Methods</h3> This is a randomised controlled trial. 24 elements had the inclusion criteria and were randomised into control and experimental group. The experimental group performed a home-based exercise program for 5 days a week during 30 minutes each one for 10 weeks, which included straight postural, muscle strength, stretching and respiratory exercises. The evaluation of the individuals performed at baseline and after 10 weeks to carry out the home-based exercise program, follow through WHOQOL-Bref to evaluate the quality of life of individuals, BASDAI, BASFI and BASMI. <h3>Results</h3> The experimental group after the program improved the levels of WHOQOL-Bref (p = 0.027 for domain 1, p = 0.008 for domain 2 and p = 0.020 for domain 4), BASDAI (p = 0.044), BASFI (p = 0.049) and BASMI (p = 0.002). No statistically significant difference was found in initial time and the end of the study of all scales in control group. Also, there were correlations between all ranges and areas of WHOQOL-Bref, except between BASFI and BASDAI (r = 0). The most relevant correlations are between BASFI and domain 3 (r = -0.643; p = 0.024), domain 1 and domain 2 (r = 0.712; p = 0.009, domain 1 and domain 4 (r = 0.642; p = 0.025) domain 2 and domain 3 (r = 0.711; p = 0.010), domain 2 and domain 4 (r = 0.665; p = 0.018), domain 3 and domain 4 (r = 0.779; p = 0.003), well as represent meaning for the population. <h3>Conclusion</h3> The home-based exercise program is an effective therapy in increasing quality of life of patients with ankylosing spondylitis. Psychological distress and fatigue was improved through better well being and quality of life.
Blockade of L-selectin enhances airway hyperresponsiveness (AHR) through inhibition of Th1 responses following allergen sensitization and challenge
Authors: K. Takeda, N. Miyahara, T. Kodama, A. Joetham, C. Taube, A. Balhorn, A. Dakhama, E.W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2003)