tbuckley/cabot-search huggingface dataset:
Endothelial cell adhesion molecule and PMNL response to inflammatory stimuli and AGE-modified fibronectin
Authors: Gürkan Sengoelge, Manuela Födinger, Sonja Skoupy, Ilse Ferrara, Christa Zangerle, Michael Rogy, Walter H. Hörl, Gere Sunder-Plassmann, Johannes Menzel
Journal: Kidney International (1998)
PRIMARY SARCOMA OF THE ESOPHAGUS AND STOMACH.
Authors: WILLIAM TRAVIS HOWARD
Journal: JAMA (1902)

<h3>PRIMARY SARCOMA OF THE ESOPHAGUS.</h3> The fact that there are only eleven cases recorded in the literature shows that this affection is rare. Most of the cases have been regarded as pathological curiosities and were reported by the following authors: Chapman, 1877; Targett, 1889; Stephan, 1890; Shaw. 1891; Rolleston, 1893; Albrecht, 1895; Ogle, 1896; Livingood, 1898; Gastpar, 1900, and Stark, 2 cases, 1900. Besides these, Perry and Shaw, in an article on malignant tumors of the stomach, allude to two cases of sarcoma of the esophagus without, however, giving either clinical or pathologic data. To the previously reported cases I am able to add another, that of a smooth muscle cell sarcoma of the lower end of the esophagus. The history is as follows: S. B., aged 51, was admitted to the Cleveland City Hospital service of Dr. Hoover, August, 1900, complaining of vomiting and difficulty in swallowing. He died
Marathon Running and Atherosclerotic Plaques
Authors: THOMAS J. BASSLER
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 January 1978Marathon Running and Atherosclerotic PlaquesTHOMAS J. BASSLER, M.D.THOMAS J. BASSLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-1-134 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Barndt and associates have found angiographic evidence of regression of atherosclerosis in all of the patients who had improvement of lipid levels with drugs and diet (Ann Intern Med 86:139-146, 1977). We have seen plaque removal in marathon runners who take up the sport late in life.A man in his 60s was under medical care for a myeloproliferative syndrome. He took up marathoning and completed several 42-km runs and a 50-km run. He stopped running for a minor surgical procedure and died unexpectedly of a cerebral hemorrhage due to malignant thrombocytosis. Sections from his left main... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: American Medical Joggers Association Centinela Hospital Inglewood, CA 90307 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByExercise and sudden death— part I 1 January 1978Volume 88, Issue 1Page: 134-134KeywordsAtheromasAtherosclerosisDietDrugsHemorrhageLipidsRunningSportsThrombocytosis Issue Published: 1 January 1978 PDF DownloadLoading ...
Integrating Public Health and Primary Care Systems
Authors: Bruce E. Landon, Kevin Grumbach, Paul J. Wallace
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PAROXYSMAL TACHYCARDIA ASSOCIATED WITH FOCAL MYOCARDITIS
Authors: RALPH H. MAJOR
Journal: JAMA (1926)

Tachycardia of ventricular origin is an uncommon condition, and the number of reported cases is comparatively small. Butterfield and Hunt,<sup>1</sup>Cohn,<sup>2</sup>Gallavardin,<sup>3</sup>Hart,<sup>4</sup>Lewis,<sup>5</sup>Marvin and White,<sup>6</sup>Robinson and Herrmann,<sup>7</sup>Scott,<sup>8</sup>Vaughan,<sup>9</sup>and Willius<sup>10</sup>have reported examples of such tachycardias. Scott, who reviewed the subject in 1922, doubted whether certain cases reported as ventricular tachycardia were correctly diagnosed, and states that, of twenty cases reported up to that time, the evidence is not convincing in more than half. Wolferth and McMillan,<sup>11</sup>in 1923, collected reports of twenty-two cases, which they regarded as examples of true ventricular paroxysmal tachycardia. Lewis has pointed out that the ventricular type of electrocardiogram is not necessarily due to paroxysmal tachycardia of ventricular origin, since a similar picture is produced when the excitation wave takes an abnormal course in the ventricle. One case of Marvin
Unusual Increased Metaiodobenzylguanidine Uptake in Liposarcoma
Authors: Giorgio Treglia, Germano Perotti, Donatella Pia Dambra, Vittoria Rufini
Journal: Clinical Nuclear Medicine (2008)

We describe an unusual case of I-123 metaiodobenzylguanidine (I-123 MIBG) uptake in a patient with myxoid liposarcoma of the thigh. A 66-year-old male underwent CT and I-123 MIBG scan to exclude a pheochromocytoma. A PET-CT was also performed because the patient had a medical history of melanoma. I-123 MIBG scan and PET-CT showed an area of increased uptake of the radiopharmaceutical in the left thigh. MRI of the thigh showed the presence of a lesion in the left vastus medialis muscle. The histologic examination of the lesion revealed the presence of a myxoid liposarcoma.
SPERMATOGENESIS FOLLOWING THERAPY WITH THE GONAD STIMULATING EXTRACT FROM THE URINE OF PREGNANCY
Authors: William L. Brosius
Journal: JAMA (1933)

The rapidly accumulating literature on the pituitary gonad relationship and the effects of the gonad stimulating extract from the human urine of pregnancy deals almost entirely with animal experimentation. The entire subject of endocrinology owes its advancement from the speculative phase of the past century to its present level chiefly to the experimentalists. Clinical studies sufficiently controlled to permit careful analysis are relatively few. The pituitary gonad relationship shows wide species differences even in members of the closely related rodent group— mice, rats, guinea-pigs and rabbits — on which most of the intensive work has been done. When information is considered from the many other species that have been studied— the frog, pigeon, duck, chicken, pig, cow, horse, dog, cat and monkey—wide variations in the mechanisms involved become apparent. This emphasizes the fallacy of predicting reactions in the human being from results obtained by animal experimentation in the pituitary gonad
Treatment of Chronic Depression-Reply
Authors: Frederick K. Goodwin
Journal: JAMA (1996)

<h3>In Reply.</h3> —The authors of these letters express a level of interest in my Clinical Crossroads discussion that is quite gratifying. With regard to Dr Chutkow's comments, I agree that ECT is a safe and effective treatment for depression, especially when it is severe and/or when antidepressants have failed to work. Although the patient under discussion had a history of major depressive episodes, in recent years he suffered from dysthymia, a condition for which ECT is not generally indicated. Chutkow also suggests that the psychiatrist should provide both psychotherapy and pharmacotherapy. While clinical experience suggests that there are some patients for whom this is best, other patients do quite well with nonmedical psychotherapists working collaboratively with the psychiatrist. Indeed, in most controlled studies demonstrating the efficacy of psychotherapy for depression, the therapists have been either psychologists or social workers.<sup>1</sup>What is surely needed are randomized trials of the comparative
A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia
Authors: Jean-Luc Harousseau, Jeffrey E. Lancet, Josy Reiffers, Bob Lowenberg, Xavier Thomas, Francoise Huguet, Pierre Fenaux, Steven Zhang, Wayne Rackoff, Peter De Porre, Richard Stone
Journal: Blood (2007)
Two cheers for bounded rationality
Authors: Raanan Lipshitz
Journal: Behavioral and Brain Sciences (2000)

Replacing logical coherence by effectiveness as criteria of rationality, Gigerenzer et al. show that simple heuristics can outperform comprehensive procedures (e.g., regression analysis) that overload human limited information processing capacity. Although their work casts long overdue doubt on the normative status of the Rational Choice Paradigm, their methodology leaves open its relevance as to how decisions are actually made.
Poisoning by Aconitine
Authors: F. S. Fiddes
Journal: BMJ (1958)

The history of poisoning by aconite is a long one, going far back into ancient times.This is not surprising, since the plant species from which the poison is derived.notably Aconitum napellus (monk's-hood) and Aconi- tum ferox, are common and widely distributed.Within modern times, however, aconite poisoning has been relatively uncommon, certainly within the United Kingdom; and poisoning with the pure alkaloid itself, aconitine, is still more rare.For this reason the symptoms are worth recording, as they occurred in two recent non-fatal cases.
Obesity-Related Plasma Hemodilution and PSA Concentration Among Men With Prostate Cancer
Authors: Lionel L. Bañez, Robert J. Hamilton, Alan W. Partin, Robin T. Vollmer, Leon Sun, Carmen Rodriguez, Yiting Wang, Martha K. Terris, William J. Aronson, Joseph C. Presti, Christopher J. Kane, Christopher L. Amling, Judd W. Moul, Stephen J. Freedland
Journal: JAMA (2007)

OBESITY INthe United States has dramatically increased in the past decade. 1Increased body mass index (BMI) has been linked to death from colon, breast, and many other cancers. 2 Although there are biological bases for increased risk of certain cancers in obese persons, 3 delayed diagnosis may provide an explanation for advanced stage of disease and poor outcome.Obesity presents technical problems for cancer detection, since adiposity may hinder physical examination and interfere with imaging and ancillary tests. 4Likewise, obesity may negatively affect early diagnosis through assessment of serum concentrations of soluble tumor markers.For example, recent evidence suggests that prostate cancer screening may be adversely affected by increased BMI. 5 In the United States, most prostate cancer cases are diagnosed by needle biopsy of the prostate prompted by a high serum prostate-specific antigen (PSA) concentration.The ability to accurately detect prostate cancer can be compromised by any factor that decreases PSA concentration in the circulation.Multiple studies have found that obese men have lower PSA con-
Comparison of Immediate and Intermediate-Term Results of Intravascular Ultrasound Versus Angiography-Guided Palmaz-Schatz Stent Implantation in Matched Lesions
Authors: Remo Albiero, Thomas Rau, Michael Schlüter, Carlo Di Mario, Bernhard Reimers, Detlef G. Mathey, Jonathan M. Tobis, Joachim Schofer, Antonio Colombo
Journal: Circulation (1997)

Background Intravascular ultrasound (IVUS) provides more precise information than angiography about vascular dimensions. This information is used by some centers to optimize intracoronary stent implantation. There are no direct comparisons of the effects on restenosis of optimal IVUS-guided versus angiography-directed high-pressure stenting. Methods and Results Lesions of patients who had a 6-month angiographic follow-up study were eligible for matching. From 445 consecutive lesions treated by Palmaz-Schatz (P-S) stenting guided by IVUS (IVUS group) in Milan, 173 lesions were individually matched with 173 of 476 consecutive lesions treated by P-S stenting directed by angiography (Angio group) in Hamburg. Lesions were selected by a computerized program according to baseline clinical, angiographic, and procedural variables. Immediate and 6-month angiographic results were retrospectively compared, distinguishing an “early phase” from a “late phase.” This distinction was based on the more aggressive dilation strategy with larger balloons and more demanding IVUS criteria for optimal stent expansion used in Milan in the early phase. In both phases, a larger minimum lumen diameter (MLD) immediately after stenting and after 6 months was achieved in the IVUS group than in the Angio group. In the early phase, the dichotomous restenosis rate was lower in the IVUS group than in the Angio group (9.2% versus 22.3%; P =.04). In the late phase, there was no difference in restenosis between the groups (22.7% versus 23.7%; P =1.0). Conclusions In matched lesions treated with high-pressure stenting, IVUS guidance achieved a larger MLD than angiographic guidance. However, in the IVUS group, the restenosis rate was lower only in the early phase, when balloons larger than currently used were selected to maximize the stent lumen area.
THE PROBLEM OF DIAGNOSIS IN SURGICAL LESIONS OF THE RIGHT ILIAC REGION
Authors: A. B. COOKE
Journal: JAMA (1923)

In some sense, most intra-abdominal operations are exploratory. After every diagnostic resource has been exhausted, it happens with disconcerting frequency that conditions are encountered at operation of a different and far more serious character than was anticipated. This is especially true in lesions of the right iliac fossa, in which the appendix so completely dominates the diagnostic picture. As a matter of fact, fully 90 per cent. of the surgical lesions of this region do originate in the appendix. But the remainder, whether 10 or only 1 per cent., constitute too large and too important a clinical group to be ignored or lightly considered. We are not concerned so much with diagnostic error as with the possible consequences of diagnostic error; for the prime object of diagnosis, when all is said, is the cure of disease, not the scientific satisfaction of solving an obscure problem. In the class of cases
Cardiac Impairment in Adrenal Insufficiency in the Cat
Authors: MICHAEL J. ROVETTO, RICHARD A. MURPHY, ALLAN M. LEFER
Journal: Circulation Research (1970)

Cardiac contractile protein ATPase activity was studied in cats 10 days after adrenalectomy at a time when the mean arterial blood pressure was 27% lower than that of control cats. The Ca 2+ -dependent, azide-insensitive ATPase activity of myofibrils isolated from the ventricles of adrenalectomized cats was 63% of the activity of control preparations ( P &lt;0.025). Similarly, the specific activities of cardiac actomyosin (myosin B) and myosin from adrenalectomized cats had decreased to 54 and 75% of control values, respectively ( P &lt;0.005). The percent reductions in ATPase activities in the three protein preparations from adrenalectomized animals were not significantly different, suggesting that the depression was associated with myosin per se. The reduction in the myosin ATPase activity in adrenal insufficiency was prevented by dexamethasone treatment adequate to prevent the decline in mean arterial blood pressure of the adrenalectomized cats. The reduction in cardiac performance in frank adrenal insufficiency may reflect a decrease in the rate of conversion of chemical to mechanical energy by the myocardial contractile proteins.
Frequency and clinical correlations of epidermal growth factor receptor (EGFR) mutations in a large cohort of Italian non-small cell lung cancer (NSCLC) patients (pts) within the EGFR FASTnet program.
Authors: Nicola Normanno, Carmine Pinto, Gian Luigi Taddei, Giancarlo Troncone, Paolo Graziano, Giovanna De Maglio, Marcella Mottolese, Vienna Ludovini, Simonetta Zupo, Luigi Maria Larocca, Elena Roz, Antonio Russo, Giuseppe Palmieri, Giuseppe Perrone, Massimo Di Maio, Andrea Ardizzoni, Lucio Crino, Francesco Perrone, Claudio Clemente, Antonio Marchetti
Journal: Journal of Clinical Oncology (2012)

e18021 Background: Gefitinib was approved in Italy for treatment of pts with advanced NSCLC carrying mutant EGFR in May 2010. Methods: The EGFR FASTnet program was designed to facilitate the exchange of biological material, clinico-pathological data and reports between medical oncologists, primary pathologists and referral laboratories. EGFR mutational analysis was carried by Sanger sequencing, Real Time PCR, Pyrosequencing, Fragment Analysis and High resolution melting. The Italian Association of Medical Oncology (AIOM) and the Italian Society of Surgical Pathology and Cytopathology (SIAPEC-IAP) have full access to the anonymous EGFR FASTnet database. Results: As of December 31, 2011, 503 oncologists, 135 pathologists and 38 referral laboratories joined the EGFR FASTnet program. The enrolled cohort of 3819 pts with advanced NSCLC was significantly enriched for adenocarcinoma histology (3172 [83%]), female sex (1361 [36%]) and smoking history (never smoker 911 [24%], former smoker&gt;15 yrs 880 [23%], light smoker 194 [5%]). Mutational analysis was feasible in 3567 pts (93%). At registration, 72% of the pts had not received yet treatment for advanced disease. Mutational analysis was carried by Sanger sequencing in 2021 cases (57%), Real Time PCR in 174 (5%), Pyrosequencing in 636 (18%) and other techniques in 736 (21%). EGFR mutations were found in 520 cases (14.6%): 334 in exon 19 (9.4%), 163 in exon 21 (4.6%), 7 in exon 18 (0.2%) and 16 in exon 20 (0.4%). Proportion of mutated cases was slightly higher with Real time PCR compared to other techniques: Sanger 14.8%, Real time PCR 21.3%, Pyrosequencing 13.5%, other 13.3% (p = 0.049). A higher mutation rate was found in never smokers (32.0%), light smokers (18.7%) and former smokers &gt;15 yrs (12.4%), as well as in adenocarcinoma (15.7%) and females (25.2%). Conclusions: The pts for EGFR mutational screening are spontaneously selected by medical oncologists according to known predictive factors. The results of the mutational analysis from clinical practice in Italy are consistent with data from literature.
Colorado Tick Fever or Ehrlichiosis
Authors: Richard T. Ellison
Journal: JAMA (1987)

<h3>To the Editor.—</h3> I read with interest the recent article by Fishbein et al<sup>1</sup>entitled "Unexplained Febrile Illnesses After Exposure to Ticks: Infection With an<i>Ehrlichia?</i>" Although the serological data are very supportive of disease due to<i>Ehrlichia</i>, I would also note that virological and serological studies were apparently not performed for Colorado tick fever (CTF). This latter infection caused by an orbivirus has many similar clinical features to the illness described by Fishbein et al, with fever, chills, headache, myalgias, and abdominal complaints occurring commonly.<sup>2</sup>A biphasic course is characteristic, but occurs in only half the cases. In addition the major laboratory abnormality of CTF is leukopenia, and lymphopenia is also frequently present.<sup>3</sup>Both thrombocytopenia and liver function abnormalities have been described.<sup>4</sup> Despite its name, CTF is endemic throughout the mountainous regions of the western United States and Canada in the distribution of<i>Dermacentor andersoni</i>
Do professions have a future?
Authors: J. Abelson, P H Maxwell, R J Maxwell
Journal: BMJ (1997)

Within the medical profession a perception exists of a growing gap between the providers and users of health care and, more generally, between the health professions and society. The commitment to serve society, a key attribute of all professions, has been questioned from within and outside the ranks of medicine, and the medical professions' powers and privileges of self regulation have been challenged.1 2 3 4 5 6 A King's Fund seminar last autumn on the future of the professions brought together a range of perspectives, including views from architecture, nursing, medicine, and politics.

Central to the implicit bargain between the profession and society is the exchange of privileges (self regulation and the control of …
Abstract 1994: Tobacco carcinogen-induced transformation of HBECs is associated with chromatin-mediated reprogramming of the epigenome
Authors: Carmen S. Tellez, Daniel E. Juri, Leander Van Neste, Christopher Hart, Yushi Liu, Kieu Do, Maria A. Picchi, Steven A. Belinsky
Journal: Cancer Research (2011)

Abstract An in vitro model, hTERT/cdk4, immortalized human bronchial epithelial cells (HBECs), was used to identify key molecular changes driving cell transformation and the clonal outgrowth of preneoplastic lung epithelial cells. Low-dose weekly treatment (12 weeks) of HBECs with genotoxic, but not cytotoxic doses of the carcinogens methylnitrosourea (MNU), benzo(a)pyrene-diolepoxide 1 (BPDE), or both induced transformation. Transformation efficiency (0.2-3%) differed between HBECs and was associated with DNA repair capacity, increased levels of DNMT1 protein, promoter hypermethylation, EMT, and stem-like cell phenotype. Agilent 44K arrays were used to determine genome-wide changes in gene expression associated with transformation. Comparison of expression between HBEC1 and HBEC2 to cells transformed by BPDE, MNU, or the combination revealed 287-321 and 320-493 genes with increased or decreased (≥ 3-fold change) expression. Approximately 214 and 331 of the genes with decreased expression in HBEC1 and HBEC2 had CpG islands that extended through their transcriptional start site. HBEC2 MNU/BPDE transformed cells were treated with DAC or TSA to assess globally whether chromatin remodeling alone, or in combination with DNA methylation mediated gene silencing. Only 128 of 331 silenced genes in HBEC2 MNU/BPDE transformed cells responded to DAC alone. Promoter methylation arrays and genome-wide ChIP-chip for inactive chromatin marks were used to elucidate mechanisms of global gene silencing in HBEC2 MNU/BPDE transformed cells. Array analysis revealed 216 genes with reduced expression are enriched for H3K27me3 and 23 novel genes with reduced expression are hypermethylated in HBEC2 MNU/BPDE transformed cells. Our in vitro model suggests that the re-programming of the epigenome during carcinogen-induced transformation is initially mediated by chromatin remodeling with ensuing DNA methylation sustaining gene silencing. The authors’ work is supported by a research grant from National Institutes of Health (R01 ES008801). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1994. doi:10.1158/1538-7445.AM2011-1994
191 EVOLUTION AFTER LISTING AND RESULTS OF LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA IN HIV/HCV AND HIV/HBV COINFECTED PATIENTS
Authors: E. Vibert, R. Adam, J.G. Tralhao, D. Azoulay, D. Castaing, D. Samuel, J.C. Duclos-Vallee
Journal: Journal of Hepatology (2008)