Management of Septic Shock: Present and Future
Authors: Joseph E. Parrillo
Journal: Annals of Internal Medicine (1991)

Editorials15 September 1991Management of Septic Shock: Present and FutureJoseph E. Parrillo, MDJoseph E. Parrillo, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-6-491 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSepsis and septic shock have been increasing in incidence for the last 60 years, and sepsis is presently the most common cause of death in intensive care units in the United States. Reasonable current estimates of annual incidence are 400 000 bouts of sepsis, 200 000 cases of septic shock, and 100 000 deaths from this disease (1). The reasons for this rising incidence include increased use of invasive devices such as intravascular and bladder catheters, more frequent corticosteroid and cytotoxic therapy, and enhanced longevity of patients (for example, patients with diabetes) who are susceptible to sepsis.The overall mortality...References1. ParrilloParkerNatansonSuffrediniDannerCunnlon JMCARR. NIH Conference. Septic shock in humans: advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med. 1990:113:227-42. LinkGoogle Scholar2. Bone R. Sepsis, the sepsis syndrome, multi-organ failure: a plea for comparable definitions [Editorial]. Ann Intern Med. 1991:114:332-3. LinkGoogle Scholar3. Bone R. The pathogenesis of sepsis. Ann Intern Med. 1991;115:457-69. LinkGoogle Scholar4. AustrianGold RJ. Pneumococcal bacteremia with special reference to bacteremic pneumococcal pneumonia. Ann Intern Med. 1964;60:759-76. LinkGoogle Scholar5. KregerCravenMcCabe BDW. 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Parrillo, MDAffiliations: Rush-Presbyterian-St. Luke's Medical Center Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExtracorporeal cytokine elimination as rescue therapy in refractory septic shock: a prospective single-center studyCombined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured miceHemodynamic Monitoring in SepsisHemodynamic Monitoring in SepsisPrompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepsis and septic shockVasopressin During Cardiopulmonary Resuscitation and Different Shock StatesSystemic inflammatory response syndromeEfficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failureMulticenter evaluation of a human monoclonal antibody to Entero-bacteriaceae common antigen in patients with Gram-negative sepsisCytokine modulation in sepsis and septic shockBacterial Toxins Induce Selective Cytokine Patterns In Vivo and In VitroRandomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES StudyA Novel Receptor Tyrosine Kinase, Mer, Inhibits TNF-α Production and Lipopolysaccharide-Induced Endotoxic ShockChylomicrons alter the hepatic distribution and cellular response to endotoxin in ratsProstaglandin I2Analogue, Iloprost, Down Regulates Mitogen-Activated Protein Kinases of MacrophagesDouble-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shockEndogenous Mediators in Sepsis and Septic ShockCurrent Status of Clinical Trials With Anti-TNFThe level of lipopolysaccharide-binding protein is significantly increased in plasma in patients with the systemic inflammatory response syndromeRole of Cytokines in SepsisExhaled nitric oxide as a marker for serum nitric oxide concentration in acute endotoxemiaInflammatory mediators in sepsis: rationale for extracorporeal therapies?Prostaglandin E sub 2 Production by Endotoxin-Stimulated Alveolar Macrophages Is Regulated by Phospholipase C PathwaysSepsis in the ElderlyADJUNCTS TO ANTIBACTERIAL THERAPYThe Systemic Inflammatory Response, Sepsis, and Multiple Organ Dysfunction: New Definitions for an Old ProblemMediator-Specific Therapies for the Systemic Inflammatory Response Syndrome, Sepsis, Severe Sepsis, and Septic Shock: Present and Future ApproachesPulmonary infiltrations in febrile patients with neutropenia. Risk factors and outcome under empirical antimicrobial therapy in a randomized multicenter studyBiologicals and Hematopoietic Cytokines in Prevention or Treatment of Infections in Immunocompromised HostsAntiendotoxin Therapy in SepsisPathogenetic Mechanisms of Septic ShockPharmacologic Cardiovascular SupportSeptic Shock Pathophysiology: Focus on Therapeutic ApproachC1-inhibitor substitution therapy in septic shock and in the vascular leak syndrome induced by high doses of interleukin-2Soft Tissue InfectionsMore on pathogenesis and treatment of septic shockInterplay of complement and cytokines in the pathogenesis of septic shock 15 September 1991Volume 115, Issue 6Page: 491-493KeywordsBladderCathetersCorticosteroid therapyCritical careForecastingIntensive care unitsInterleukinsMortalitySepsisShock ePublished: 1 December 2008 Issue Published: 15 September 1991 PDF downloadLoading ...