tbuckley/cabot-search huggingface dataset:
Endoscopic ultrasound-guided ethanol lavage of a pancreatic fluid collection
Authors: N. Muscatiello, L. Pietrini, M. Gentile, P. Tonti, C. Ricciardelli, I. Sorrentini, E. Ierardi
Journal: Endoscopy (2006)

A 30-year-old man with a history of alcohol abuse developed a large pseudocyst (89 × 78 mm) in the tail of the pancreas (Figure [1]) following a single episode of acute severe pancreatitis with multiple organ dysfunction syndrome. As the patient declined any form of surgery, endoscopic decompression of the pseudocyst was carried out with real-time endoscopic ultrasound (EUS) guidance (Figure [2]) after informed consent had been obtained. With the patient under general anesthesia, EUS was conducted with a Pentax FG-36UA ultrasound endoscope (Pentax Europe, Ltd., Hamburg, Germany) using a curved-array transducer with fluoroscopic guidance [1]. The pseudocyst was visualized as a bulge on the posterior gastric wall, and the shortest access route (about 10 mm) in which there were no interposed vessels was clearly identified. A 19-Fr needle (Cook Medical Inc., Bloomington, Indiana, USA) was introduced through the endoscope’s working channel to puncture the pseudocyst and inject 30 ml iopromide (Ultravist) contrast. No communication with the pancreatic duct was visible.
Anomalies of peristalsis in idiopathic diffuse oesophageal spasm.
Authors: M D Kaye
Journal: Gut (1981)

Oesophageal manometry revealed 9interrupted peristalsis9--proximal sequential contraction with simultaneous pressure increases in the mid-oesophagus and sequential contraction distally--and abnormally slow distal propagation of peristalsis in seven of a consecutive series of 12 patients with idiopathic diffuse oesophageal spasm (IDOS). These two abnormalities occurred together in six patients. It is proposed that 9interruption9 of peristalsis and 9slow9 distal propagation are apparent rather than real, and that they reflect failure of normal luminal obliteration during oesophageal contraction. This arguments is extended to the 9aperistalsis9 of achalasia. It is also proposed that IDOS, achalasia, and related idiopathic motor disorders may share a common pathogenetic abnormality--namely, functional obstruction at the level of the lower oesophageal sphincter. According to this hypothesis, the presentation of the patient and the progression of his disease are determined by the degree and duration of that obstruction, and the functional reserve of the oesophageal body musculature.
Incompatibility in Homologous Transfusion
Authors: G. C. Dockeray, H. Sachs
Journal: BMJ (1942)

POISONING MEDICALJUTRNAL Other Substances.-None of the 431 urines contained blood, sugar, bile pigments, or urobilin; 4 contained urobilinogen and considerable porphyrins.A large amount of albumin was present in 1 and a faint trace in 107.Porphyrins were found in 10% more of the albumin-free specimens than of those con- taining albumin, suggesting that albuminuria is not a factor in the production of porphyrinuria. CommentsRoutine examination for crude porphyrinuria should pro- vide a guide to the progress and cure of actual cases of T.N.T. poisoning, and its detection might assist in confirming the diagnosis in suspected cases.The incidence of porphyrinuria found in the series of 431 workers in contact with T.N.T. sug- gests that it is probably present during the development of symptoms-and possibly for some time-while the worker's health is subnormal and before disablement compels him to cease work.-Routinetesting of T.N.T. workers for por- phyrinuria might reveal those being affected deleteriously by the T.N.T. in the pre-disablement stage-i.e., before symptoms compel them to report unfit.By this means workers specially susceptible or hypersensitive to T.N.T. would be known.The rapid simple method of liberating the crude porphyrin mixture detailed above would suffice for this purpose.By classifying the results as + +, +, ±, +, or 0, as explained above, we obtain a rough measure of the degree of porphyriniuria.Removing positive workers from contact should improve health and efficiency; but until a further survey, to include the clinical examination of positive workers, has been undertaken we would suggest that + + and + workers might be removed and + workers watched and tested again.We consider this rapid test for crude porphyrinuria in T.N.T. workers yields information unobtainable from the Webster test and might usefully replace it.In acute porphyria following sulphonal, trional, veronal, etc., abdominal pain, vomiting, constipation, and jaundice occur, and the severe toxic manifestations after use of the benzene- sulphonamide drugs include headaches, giddiness, drowsiness, sickness, vomiting, cyanosis, colic, anaemia, and jaundice; even a dermatitis sometimes occurs.Long and Bliss (1938) discussed
The Sicilian Gambit: reasons for maintaining the present antiarrhythmic drug classification
Authors: D. C Harrison
Journal: Cardiovascular Research (1992)

Journal Article The Sicilian Gambit: reasons for maintaining the present antiarrhythmic drug classification Get access Donald C Harrison Donald C Harrison University of Cincinnati, College of Medicine, 250 Health Professions Building, Cincinnati, Ohio 45267 0663, USA: Professor D C Harrison. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 6, June 1992, Pages 566–567, https://doi.org/10.1093/cvr/26.6.566 Published: 01 June 1992 Article history Received: 09 March 1992 Accepted: 19 March 1992 Published: 01 June 1992
Book Review Radiographic Atlas of Child Abuse: A case studies approach By Vivian J. Harris, Michele A. Lorand, John J. Fitzpatrick, and Demetra K. Soter. 239 pp., illustrated. New York, Igaku-Shoin, 1996. $89.50. 0-89640-258-4
Authors: Philip Stanley
Journal: New England Journal of Medicine (1996)
Cutaneous T-cell lymphoma associated with granular lymphocytic leukemia in its terminal stage
Authors: Akemi Seno, Akiko Okatani, Masato Miyashita, Noriko Hirano, Jirô Arata, Norihiro Teramoto, Tadashi Yoshino, Tadaatsu Akagi, Haruko Katayama
Journal: Journal of the American Academy of Dermatology (1992)
Ticagrelor Enhances Adenosine-Induced Coronary Vasodilatory Responses in Humans
Authors: Ann Wittfeldt, Håkan Emanuelsson, Gunnar Brandrup-Wognsen, J.J.J. van Giezen, Jenny Jonasson, Sven Nylander, Li-Ming Gan
Journal: Journal of the American College of Cardiology (2013)
Women in medicine: two points of view. II. Medicine and motherhood
Authors: M. Heins
Journal: JAMA (1983)

IN THE preceding COMMENTARY, Dr Dimond makes two cogent points: (1) that discrimination directed against women entering medical education has ended and (2) that a major task before women physicians is to solve career-family conflicts. He suggests that women should learn how to delegate tasks in a "professional household." Most women physicians will agree with him. Dr Dimond is correct when he says that the major battle has been won. The system has responded, perhaps as rapidly as any system in history. Not only are women entering medical school in unprecedented numbers, but complaints of sexism have greatly diminished. Although many schools have women's support groups, the sheer numbers of women make it possible for women not only to<i>be</i>in medical school, but to feel comfortable there. Women are beginning to be accepted even in those residency programs once thought to be "for men only." There is also slow
Diabetic neuropathy examination: a hierarchical scoring system to diagnose distal polyneuropathy in diabetes.
Authors: J W Meijer, E van Sonderen, E E Blaauwwiekel, A J Smit, J W Groothoff, W H Eisma, T P Links
Journal: Diabetes Care (2000)

Existing physical examination scoring systems for distal diabetic polyneuropathy (PNP) do not fulfill all of the following criteria: validity, manageability, predictive value, and hierarchy The aim of this study was to adapt the Neuropathy Disability Score (NDS) to diagnose PNP in diabetes so that it fulfills these criteria.A total of 73 patients with diabetes were examined with the NDS. Monofilaments and biothesiometry were used as clinical standards for PNP to modify the NDS.A total of 43 men and 30 women were studied; mean duration of diabetes was 15 years (1-43), and mean age was 57 years (19-90). A total of 24 patients had type 1 diabetes, and 49 patients had type 2 diabetes. Clinically relevant items were selected from the original 35 NDS items (specific item scored positive in >3 patients). The resulting 8-item Diabetic Neuropathy Examination (DNE) score could accurately predict the results of the clinical standards and is strongly hierarchical (H value 0.53). The sensitivity and specificity of the DNE at a cut-off level of 3 to 4 were 0.96 and 0.51 for abnormal monofilament scores, respectively. For abnormal vibration perception threshold scores, these values were 0.97 and 0.59, respectively. Reproducibility as assessed by inter- and intrarater agreement was good.The DNE is a sensitive and well-validated hierarchical scoring system that is fast and easy to perform in clinical practice.
Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)
Authors: Anne Goodeve, Jeroen Eikenboom, Giancarlo Castaman, Francesco Rodeghiero, Augusto B. Federici, Javier Batlle, Dominique Meyer, Claudine Mazurier, Jenny Goudemand, Reinhard Schneppenheim, Ulrich Budde, Jorgen Ingerslev, David Habart, Zdena Vorlova, Lars Holmberg, Stefan Lethagen, John Pasi, Frank Hill, Mohammad Hashemi Soteh, Luciano Baronciani, Christer Hallden, Andrea Guilliatt, Will Lester, Ian Peake
Journal: Blood (2006)
FDA Advisor Conflicts
Authors: Bridget M. Kuehn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life-Threatening Ventricular Tachycardia and Fibrillation Induced by Painless Myocardial Ischemia During Exercise Testing
Authors: Robert A. Hong
Journal: JAMA (1987)

The clinical importance of myocardial ischemia without associated symptoms in patients with atherosclerotic coronary disease has not been clarified. We present three patients in whom painless cardiac ischemia was associated with the induction of cardiac arrest and/or ventricular tachycardia/fibrillation. In the two surviving patients, programmed ventricular stimulation did not induce ventricular arrhythmias. In one patient, successful coronary bypass surgery resulted in the elimination of exercise-induced painless myocardial ischemia and associated ventricular fibrillation; the other patient suffered a myocardial infarction after which ischemia and ventricular tachyarrhythmias could not be reproduced with exercise testing. We conclude that painless myocardial ischemia can cause life-threatening arrhythmias and is, therefore, a potentially lethal phenomenon.
Linkage of high-density lipoprotein–cholesterol concentrations to a locus on chromosome 9p in Mexican Americans
Authors: Rector Arya, Ravindranath Duggirala, Laura Almasy, David L. Rainwater, Michael C. Mahaney, Shelley Cole, Thomas D. Dyer, Ken Williams, Robin J. Leach, James E. Hixson, Jean W. MacCluer, Peter O'Connell, Michael P. Stern, John Blangero
Journal: Nature Genetics (2001)
National crash call number is needed
Authors: S. A Beshyah, R. Schiff, F. S Al-Jehani
Journal: BMJ (1996)

Table 1-Prevalence of antibody to H pyloni and C pneumoniae in patients with acute myocardial infarction and controls.Figures are numbers (percentages) Patients with acute myocardial infarction (n = 37) Controls (n = 60) C pneumonlae C pneumonlae C pneumonlse C pneumonlae positive negative positive negative H pylon positive 28 (76) 4 (11) 12 (20) 20 (33) H pylori negative 3 (8) 2 (5) 18 (30) 10 (17)bacteria, mediated by IgE, could be responsible for the enhanced production of interleukin 6.The intense proinflammatory and procoagulant properties of this cytokine could account for most, if not for all, acute coronary syndromes.
Cardiology in the Elderly
Authors: David H. Miller
Journal: JAMA (1995)

The study of cardiovascular illness in the elderly has become increasingly important, as both the mean age of the population and life expectancy increase. The journal<i>Cardiology in the Elderly</i>addresses both preclinical and clinical cardiac issues in this patient group. The journal is broken down into several sections. "Clinical Investigation" includes clinical trials and observational studies of disease processes and treatment patterns in the elderly population. "Features" encompasses editorials, editorial reviews, and case reports. "Review in Depth" is a collection of reviews on different aspects of a specific topic (for instance, a review in depth on invasive cardiology included review articles on thrombolytic therapy, coronary angioplasty, surgical myocardial revascularization, and balloon valvuloplasty). Each review has an annotated bibliography. "Bibliography of the Current World Literature" is an overwhelming list of hundreds of journal articles. Many of these, though relevant, are not specifically dedicated to cardiac disease in the elderly. The
Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7
Authors: Reinhard Höpfl, Kurt Heim, Neil Christensen, Klaus Zumbach, Ulrike Wieland, Birgit Volgger, Andreas Widschwendter, Sandra Haimbuchner, Elisabeth Müller-Holzner, Michael Pawlita, Herbert Pfister, Peter Fritsch
Journal: The Lancet (2000)
P661Melanoma tumor in mice alters cardiac metabolism and signaling and promotes heart failure in part by STAT3 activation
Authors: B Stapel, J Thackeray, A Haghikia, M Ricke-Hoch, S Erschow, F Bengel, D Hilfiker-Kleiner
Journal: Cardiovascular Research (2014)

Purpose: Patients suffering from heart failure or advanced cancer share clinical symptoms including limited exercise capacity, shortness of breath and early fatigue, and develop skeletal and cardiac muscle atrophy. The systemic effects of cancer on the heart are poorly understood. We investigated molecular and metabolic changes of the heart in a B16F10 melanoma mouse cancer model. Methods: B16F10 melanoma tumor was induced by intraperitoneal implantation of B16F10 cells. Morphological, histological and molecular biological (Western Blot, qRT-PCR) analyses, echocardiography and glucose uptake by FDG-PET were carried out 3 weeks later. Results: Tumor growth was confirmed morphologically and by FDG-PET analysis. Tumor-bearing wildtype (C57BL6) mice displayed cardiac atrophy and high mortality (control: 0% vs tumor mice: 66%, P<0.01, n=17-25). In surviving tumor mice, systolic function was depressed (control, FS: 39% vs tumor mice, FS: 23%, P<0.01, n=9-12) and LV wall thickness was reduced. Total MHC protein was decreased (-30%) while tropomyosin and troponin T level were not altered and no changes in LV tissue composition, e.g. fibrosis or inflammation were detected in tumor mice compared to controls. Reduced cardiac FDG uptake in tumor mice suggests impaired myocardial glucose metabolism (-81% vs baseline prior tumor, P<0.01, n=5) paralleled by increased FDG uptake in the growing tumor. mRNA level of CPT1a and b, two key enzymes of fatty acid oxidation, were increased (CPT1a: +2.2-fold; CPT1b: +1.7-fold; P<0.01) and protein level of fatty acid transporter CD36 were significantly elevated (+1.8-fold; P<0.05) in tumor mice, indicating compensatory upregulation of fatty acid utilization. Analysis of myocardial signaling pathways revealed strong induction of STAT3 phosphorylation (tumor mice: 85-fold, P<0.01, n=5) while activation of p38, AKT, and ERK1/2 were unaltered. Conditioned medium from B16-F10 cells induced constitutive activation of STAT3 signaling by 5-fold (P<0.01) over 3 days, and was associated with downregulated protein expression of glucose transporter 4 (-27%, P<0.05). Mice with a cardiomyocyte-specific knockout of STAT3 (αMHC-Cre; STAT3flox/flox: CKO, n=4) were protected from B16F10-induced heart failure compared to wildtype siblings (STAT3flox/flox, n=6: WT, FS: 27% vs CKO, FS: 58% P<0.05). Conclusion: B16F10 melanoma tumor evokes alterations in cardiac signaling, induces changes in myocardial metabolism and promotes cardiac atrophy and failure. At least part of these adverse effects of B16F10 melanoma on the heart seem to be mediated by constitutive activation of STAT3 in cardiomyocytes.
Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk
Authors: Catherine Schairer
Journal: JAMA (2000)

COLLABORATIVE REanalysis of more than 90% of the world's epidemiological data on the relationship between menopausal hormone replacement therapy (HRT) and breast cancer risk, it was found that longer durations of recent, but not past, use of HRT increased breast cancer risk, particularly among leaner women and for tumors that were less clinically advanced. 1Unresolved issues include the extent to which the findings were due to a biological effect of hormones rather than issues of screening and ascertainment.The data were also insufficient to determine whether a combined estrogen-progestin regimen increased risk beyond that associated with estrogen alone.In 1994, we published data on HRT and breast cancer risk from a follow-up study conducted among former participants in a breast cancer screening program. 2 Cases were diagnosed through 1989.Those data were included in the collaborative analysis. 1In this article, we expand our previous analysis to include cases diagnosed in the follow-up study through 1995, almost doubling the total number of cases.The collection of additional data on mammographic screening and use of the combined estrogen-progestin regimen allowed us to address some issues left unresolved. METHODS Follow-up StudyStudy subjects were participants in the Breast Cancer Detection Demonstration Project (BCDDP) conducted between 1973 and 1980.We previously described a follow-up study begun in 1979 involving a subset of BCDDP participants. 2In brief, the follow-up study included (1) all screening participants who underwent breast surgery during the screening period, with no evidence of malignant disease (n = 25 114);(2) all subjects who had recommenda-tions by the project for a surgical consultation but did not have either a biopsy or aspiration performed (n = 9628); and (3) a sample of women who had neither surgery nor recommendation for
Hepatic and renal metabolism of somatostatin-like immunoreactivity. Simultaneous assessment in the dog.
Authors: K S Polonsky, J B Jaspan, M Berelowitz, D S Emmanouel, J Dhorajiwala
Journal: Journal of Clinical Investigation (1981)

The hepatic and renal metabolism of somatostatin-like immunoreactivity (SLI) was assessed simultaneously in an in vivo dog model. The hepatic extraction of this peptide was 29.4 +/- 2.3% and was similar for endogenous and infused exogenous SLI. The renal extraction was 62.3 +/- 5%. The renal clearance of SLI was significantly greater than that of inulin indicating that the peptide is handled by peritubular uptake from postglomerular blood in addition to glomerular filtration. In both organs SLI extraction was not saturable even at arterial concentrations in excess of 100 times physiological range. The overall metabolic clearance rate of SLI was 19.7 +/- 1.6 ml/kg per minute of which 32.7 +/- 4.6% was contributed by hepatic and 37 +/- 4.9% by renal uptake mechanisms. The plasma half disappearance time of exogenously infused SLI was 1.9 +/- 0.3 min. The studies indicate that in the dog, the liver and kidney are both major sites of SLI metabolism, together accounting for 70.0 +/- 8.7% of the metabolic clearance of the peptide.
Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: results from APL 93 trial
Authors: S de Botton, S Chevret, V Coiteux, H Dombret, M Sanz, J San Miguel, D Caillot, A Vekhoff, M Gardembas, A Stamatoulas, E Conde, A Guerci, C Gardin, M Fey, D Cony Makhoul, O Reman, J de la Serna, F Lefrere, C Chomienne, L Degos, P Fenaux
Journal: Leukemia (2003)
Pulmonary and Hepatic Complications of Methotrexate Therapy of Psoriasis
Authors: Donald J. Filip
Journal: JAMA (1971)

Recently, methotrexate has been suspected of causing a severe pulmonary disease when administered for a long term to patients with acute leukemia in remission. Both pulmonary and liver disease developed in a patient with psoriasis after five years of weekly methotrexate therapy.
Pathogenesis of postoperative recurrence in Crohn's disease
Authors: T. Ahmed, F. Rieder, C. Fiocchi, J.-P. Achkar
Journal: Gut (2010)

The majority of patients with Crohn's disease (CD) require surgery during the course of their disease, but such surgery is typically not curative. Although some studies suggest that the disease state is theoretically reset to its earliest phase following surgery, disease phenotype and natural history of CD do not change significantly after surgery, leading to high rates of recurrence. Factors predisposing to this recurrence are not well defined, so there is a need for and a unique opportunity to develop a better understanding of the pathogenesis of recurrent inflammation and associated risk factors after an ileocolic resection. This paper reviews the postoperative disease outcome and evolution based on defining the combination of the patient's microbial flora, environmental exposure history, immune response and genetic make-up.
Influence of maternal obesity on subcutaneous fat in the newborn.
Authors: A G Whitelaw
Journal: BMJ (1976)

Skinfold thickness measurements were made at biceps, triceps, subscapular, and suprailiac sites on both sides on 265 full-term newborn infants. The mothers were classified as thin (25), normal (179), or obese (61) on the basis of their triceps skinfold thicknesses. At all skinfold sites the babies of the obese mothers were significantly fatter than the babies of normal mothers, and the babies of the normal mothers were significantly fatter than those of the thin mothers. There was a highly significant positive correlation between maternal triceps thickness and the baby9s sum of skinfold thicknesses. Hypertension was common during the pregnancies of the obese mothers and was associated with a significant reduction in the babies9 skinfold thicknesses. When each of the 61 obese mothers were matched for parity, blood pressure, and smoking habit with 61 non-obese mothers the babies of the obese mothers still had significantly greater skinfold thicknesses than the babies of non-obese mothers.
Liquid-crystalline aromatic–aliphatic copolyester bioresorbable polymers
Authors: Horacio Montes de Oca, Joanne E. Wilson, Andrew Penrose, David M. Langton, Anthony C. Dagger, Melissa Anderson, David F. Farrar, Christopher S. Lovell, Michael E. Ries, Ian M. Ward, Andrew D. Wilson, Stephen J. Cowling, Isabel M. Saez, John W. Goodby
Journal: Biomaterials (2010)