Malathion Poisoning Treated with Protopam
Authors: WILLIAM C. AMOS
Journal: Annals of Internal Medicine (1965)

Case Studies1 May 1965Malathion Poisoning Treated with ProtopamWILLIAM C. AMOS JR., M.D., ALLAN HALL, M.D.WILLIAM C. AMOS JR., M.D.Search for more papers by this author, ALLAN HALL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1013 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past year, our attention was directed toward the management of a case of organic phosphate toxicity caused by the insecticide malathion. Although there are many reports pertaining to poisonings of this type, a review of the American literature reveals only six previously reported cases of malathion intoxication (1-6). All of these patients were children, and in only two was poisoning a result of oral ingestion. The patient to be presented differs in that he was a teenager who poisoned himself attempting suicide. Of the various organic phosphate insecticides, malathion is commonly seen in the home, as it has...References1. PARKERCHATTIN GFWR: A case of malathion intoxication in a ten-year-old girl. J. Indiana Med. Ass. 48: 491, 1955. Google Scholar2. MCLAUGHLINSNYDER LACH: Encephalopathy in a child following exposure to malathion. Ochsner Clin. Rep. 2: 37, 1956. MedlineGoogle Scholar3. TUTHILL JW: Toxic hazards: malathian poisoning. New Eng. J. Med. 258: 1018, 1958. CrossrefMedlineGoogle Scholar4. MICHENFELDERTERRYDAW JDHREF: Nerve poisoning by the organic phosphates: the role of the anesthesiologist. Anesth. Analg. (Cleveland) 40: 397, 1961. MedlineGoogle Scholar5. WENZLBURKE JEEC: Poisoning from a malathion aerosol mixture. JAMA 132: 495, 1962. CrossrefGoogle Scholar6. GOLDMANTEITEL HM: Malathion poisoning in a 34-month-old child following accidental ingestion. J. Pediat. 52: 76, 1958. CrossrefMedlineGoogle Scholar7. HEALY JK: Ascending paralysis following malathion intoxication: a case report. Med. J. Aust. 46: 765, 1959. CrossrefMedlineGoogle Scholar8. PETTY CS: Organic phosphate insecticide poisoning. Residual effects in two cases. Amer. J. Med. 24: 467, 1958. CrossrefMedlineGoogle Scholar9. WILSONGINSBERG IBSA: Powerful reactivator of alkylphosphate-inhibited acetycholinesterase. Biochem. Biophys. Acta 18: 168, 1955. CrossrefMedlineGoogle Scholar10. KEWITZWILSON HIB: A specific antidote against lethal alkylphosphate intoxication. Arch. Biochem. 60: 261, 1956. CrossrefMedlineGoogle Scholar11. GROBJOHNS DRJ: Use of oximes in the treatment of intoxication by anticholinesterase compounds in normal subjects. Amer. J. Med. 24: 497, 1958. CrossrefMedlineGoogle Scholar12. NAMBAHIRAKI TK: PAM (pyridine-2-aldoxime methiodide) therapy for alkylphosphate poisoning. JAMA 166: 1834, 1958. CrossrefMedlineGoogle Scholar13. PAGEVERHULST LAHL: The oximes and organophosphate poisoning. Amer. J. Dis. Child. 103: 185, 1962. MedlineGoogle Scholar14. GORDONFRYE ASCW: Large dose of atropine: low toxicity and effectiveness in anticholinesterase intoxication. JAMA 159: 1181, 1955. CrossrefMedlineGoogle Scholar15. SIM VM: Medical aspects of chemical warfare. JAMA 175: 1, 1961. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Falls Church, VirginiaFrom the Department of Internal Medicine and Surgery, The Fairfax Hospital, Falls Church, Va.Requests for reprints should be addressed to William C. Amos, Jr., M.D., 203 Southwick Street, Fairfax, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDraft Toxicological Profile for MalathionSquare-wave voltammetry of some bipyridinium oximesHepatic and extrahepatic malathion carboxylesterases. Assay and localization in the ratMalathion PoisoningTreatment of malathion poisoning.Beitrag zu Verlauf und Behandlung schwerer Alkylphosphatvergiftungen 1 May 1965Volume 62, Issue 5Page: 1013-1016KeywordsChildrenFallsHospital medicineIngestionInsecticideIntoxicationPhosphatesSuicideSurgeryToxicity Issue Published: 1 May 1965 PDF downloadLoading ...