Relapse of Candida parapsilosis Endocarditis After Long-Term Suppression with Flucytosine: Retreatment with Valve Replacement and Ketoconazole
Authors: LAWRENCE E. SAMELSON
Journal: Annals of Internal Medicine (1980)

Brief Reports1 December 1980Relapse of Candida parapsilosis Endocarditis After Long-Term Suppression with Flucytosine: Retreatment with Valve Replacement and KetoconazoleLAWRENCE E. SAMELSON, M.D., STEPHEN A. LERNER, M.D., LEON RESNEKOV, M.D., CONSTANTINE ANAGNOSTOPOULOS, M.D.LAWRENCE E. SAMELSON, M.D., STEPHEN A. LERNER, M.D., LEON RESNEKOV, M.D., CONSTANTINE ANAGNOSTOPOULOS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-6-838 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFungal endocarditis responds poorly to medical therapy (1, 2). Therapeutic recommendations now include early surgery and aggressive use of antifungal drugs (3, 4). With increasing numbers of reports of late relapses, the definition of cure has now come into doubt (2, 5). We describe here a case of Candida parapsilosis endocarditis in a patient who relapsed after 7 years of suppressive therapy with flucytosine.A 36-year-old female heroin abuser developed C. parapsilosis mitral valve endocarditis in September 1970. She needed excision of the infected valve and replacement with a #27 Björk-Shiley mitral valve prosthesis. After surgery the patient received 1.12...References1. MCLEODREMINGTON RJ. Fungal endocarditis. In: RAHIMTOOLA SH, ed. Infective Endocarditis. New York: Grune and Stratton; 1978:211-90. Google Scholar2. RUBINSTEINNORIEGASIMBERKOFFHOLZMANRAHAL EEMRJ. Fungal endocarditis; analysis of 24 cases and review of the literature. Medicine (Baltimore). 1975;54:331-44. MedlineGoogle Scholar3. UTLEYMILLSROE JJB. The role of valve replacement in the treatment of fungal endocarditis. J Thorac Cardiovasc Surg. 1975;69:255-8. CrossrefMedlineGoogle Scholar4. MARTINPANCOASTNEU ESH. Candida parapsilosis endocarditis: medical and surgical cure. Ann Intern Med. 1979;91:870-1. LinkGoogle Scholar5. GALCIANISTEVENS JD. Fungal endocarditis: need for guidelines in evaluating therapy: experience with two patients previously reported. J Thorac Cardiovasc Surg. 1977;73:293-6. CrossrefMedlineGoogle Scholar6. HOEPRICHINGRAHAMKLEKERWINSHIP PJEM. Development of resistance to 5-fluorocytosine in Candida parapsilosis during therapy. J Infect Dis. 1974;130:112-8. CrossrefMedlineGoogle Scholar7. BORELLIFUENTESLEIDERMAN DJE. Ketoconazole, an oral antifungal; laboratory and clinical assessment of imidazole drugs. Post-grad Med J. 1979;55:657-61. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Chicago School of Medicine Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRecurrent candida prosthetic endocarditis over fifteen years managed with medical therapy and four valvular surgeries: a case report and review of literatureCandida parapsilosis Endocarditis Presenting on Native Valve With Cerebrovascular Accident and Myocardial InfarctionSuccessful Surgical Intervention for the Management of Endocarditis due to Multidrug Resistant Candida parapsilosis: Case Report and Literature ReviewCandida parapsilosis endocarditis 8 months after transient candidemiaA meta-analysis of medical versus surgical therapy for Candida endocarditisTransplantation of Yeast-Infected Cardiac Allografts: A Report of 2 CasesRecommendations for the surgical treatment of endocarditisFungal Prosthetic Valve Endocarditis in 16 Patients An 11-Year Experience in a Tertiary Care HospitalMedical Treatment of Recurrent Candidemia in a Patient With Probable Candida parapsilosis Prosthetic Valve EndocarditisLate Recurrent Candida EndocarditisA case of Candida parapsilosis endocarditisEpidemic Postsurgical Candida Parapsilosis EndophthalmitisWangiella dermatitidis endocarditis in an intravenous drug userKetoconazole; Mechanism of Action, Spectrum of Activity, Pharmacokinetics, Drug Interactions, Adverse Reactions and Therapeutic UseKetoconazole : spectre, pharmacocinétique, tolérance et activité thérapeutique dans les mycoses profondesCandidal infection in the central nervous systemProsthetic valve endocarditis caused by Trichosporon cutaneum 1 December 1980Volume 93, Issue 6Page: 838-839KeywordsAntifungalsCandidaDrugsEndocarditisHeroinInterleukinsMitral valve replacementProsthetic device infectionsSurgeryValve replacement Issue Published: 1 December 1980 PDF DownloadLoading ...