tbuckley/cabot-search huggingface dataset:
Decreased Red Cell Uroporphyrinogen I Synthetase Activity in Intermittent Acute Porphyria
Authors: L. James Strand, Urs A. Meyer, Bertram F. Felsher, Allan G. Redeker, Harvey S. Marver
Journal: Journal of Clinical Investigation (1972)

Intermittent acute porphyria has recently been distinguished biochemically from other genetic hepatic porphyrias by the observation of diminished hepatic uroporphyrinogen I synthetase activity and increased delta-aminolevulinic acid synthetase activity. Since deficient uroporphyrinogen I synthetase may be reflected in nonhepatic tissues, we have assayed this enzyme in red cell hemolysates from nonporphyric subjects and from patients with genetic hepatic porphyria. Only patients with intermittent acute porphyria had decreased erythrocyte uroporphyrinogen I synthetase activity which was approximately 50% of normal. The apparent K(m) of partially purified uroporphyrinogen I synthetase was 6 x 10(-6)m in both nonporphyrics and patients with intermittent acute porphyria. These data provide further evidence for a primary mutation affecting uroporphyrinogen I synthetase in intermittent acute porphyria. Further-more, results of assay of red cell uroporphyrinogen I synthetase activity in a large family with intermittent acute porphyria suggest that this test may be a reliable indicator of the heterozygous state.
In vitro fertilisation
Authors: H I Abdalla, T Leonard, R J Baber, A Kirkland, P A R Stocker, E C Owen, J W W Studd
Journal: BMJ (1988)

insulin to cover meals there is likely to be sufficient B cell failure for continuation ofa sulphonylurea to be of marginal benefit, and it can be withdrawn.Simple guidelines on the use of tablets and insulin4 can cater for most patients until long term studies show a different regimen to be particularly bene- ficial.
Surfactant Therapy and Nasal Continuous Positive Airway Pressure for Newborns with Respiratory Distress Syndrome
Authors: Henrik Verder, Bengt Robertson, Gorm Greisen, Finn Ebbesen, Per Albertsen, Kaare Lundstrom, Thorkild Jacobsen
Journal: New England Journal of Medicine (1994)

In southern Scandinavia most babies with respiratory distress syndrome are initially treated with nasal continuous positive airway pressure. We performed a multicenter trial to investigate whether the addition of a single dose of porcine surfactant administered during a short intubation before the occurrence of serious deterioration could reduce the subsequent need for mechanical ventilation.
Viruses and Human Cancer
Authors: David W. Allen, Philip Cole
Journal: New England Journal of Medicine (1972)

THE contention that viruses may cause cancer in man rests mainly on analogy with observations in other species, particularly laboratory animals.1,2 However, even if tumor viruses were known not to cause human cancer they would be a suitable starting place for the study of genetic mechanisms in neoplasia. Oncogenic viruses have from seven to 50 genes, only a few of which are required to confer malignancy on an infected cell. These viruses obviously represent a more promising place to search for oncogenic genes than mammalian cells, which contain two million genes or more.3,4Approaches to Cancer VirusesViruses probably evolved . . .
Exercise-induced ischemta may remain “silent” because it involves a smaller mass of the left ventricle: Tomo-craphic thallium studies in dogs and humans
Authors: Randolph E Patterson, RL Eisner, D Shonkoff, KG Cloninger, J Cedarholm, SE Martin, AL Churchwell, LL Battey, HA Liberman, DC Morris
Journal: Journal of the American College of Cardiology (1991)
Psychic energy; its source and its transformation
Authors: Garfield Tourney
Journal: JAMA (1963)

This presentation of Jungian psychology first appeared in 1947 and now has been reissued with several changes and additions. The typography has been altered, the bibliography extended to include the more recent works of C. G. Jung that have appeared in English translation, and a more detailed index prepared. However, the content of the work remains essentially the same. Jungian psychology is a strange yet fascinating amalgam of philosophy, psychopathology, mythology, oriental religion, symbolism, and alchemy. Dr. Harding is able to synthesize a number of Jung's ideas without falling into her teacher's patterns of abstruse scholarship and obscurantism. However, many of these concepts continue to be vague and difficult to formulate in a more meaningful and scientific language. For example, the meaning of psychic energy itself is never really clarified, and one must admit that this remains a confusing concept as stated in Freudian and Jungian hypotheses. Certainly there is
Amniotic Fluid α-Fetoprotein in the Prenatal Diagnosis of Fetal Neural Tube Defects
Authors: Robert L. Summitt
Journal: JAMA (1980)

This issue ofThe Journalcontains a review of the largest single experience yet reported in the literature of the application of amniotic fluid α-fetoprotein (AFP) measurement in the prenatal diagnosis of fetal neural tube defects (p 2731). The author of the review, Aubrey Milunsky, MD, is a pediatrician and medical geneticist, director of the Genetics Division of the Eunice Kennedy Shriver Center in Waltham, Mass. His laboratory has been involved in the prenatal diagnosis of neural tube defects using AFP measurement since the early 1970s, and this experience has given him a unique insight into the advantages, limitations, and pitfalls of this technological advance. As Dr Milunsky points out, a defect in the closure of the embryonic neural tube (anencephaly, exencephaly, iniencephaly, encephalocele, meningocele, or meningomyelocele) occurs in one in approximately 500 liveborn infants in the United States. A couple who has had a previous infant with a neural
The Freudian Influence
Authors: Charles D. Aring
Journal: JAMA (1977)

THE IDEAS of Sigmund Freud have had the widest impact in medicine and have also influenced anthropology, education, sociology, art, literature, and other areas. His ideas have filtered into the common consciousness. I recall words uttered long ago by my revered chief, Stanley Cobb, to the effect that one needn't concern himself about the seeming resistance to Freudian principles, since they are engrained in the culture and ubiquitous. Freud is honored even in resistance to his precepts. Like anyone leading a new cause, Freud attracted a number of followers, naturally nowhere near as wise or innovative as their master. They attempted to fix the discipline into pattern and hold it steady, seemingly unaware of or indifferent to Freud's observation that "it is the external changefulness of life that makes it so beautiful." By word and deed Freud advocated change; one need only examine his career to see how he continued
Heart Valve Infections
Authors: Janet M. Torpy, Alison E. Burke, Richard M. Glass
Journal: JAMA (2007)

Heart Valve InfectionsH eart valves allow one-way flow of blood through the heart.Damaged heart valves that do not open completely (called stenosis) or close completely (called regurgitation) are susceptible to infection because they cause abnormal blood flow through the valve.Infections of heart valves (known as endocarditis) are serious and can be life-threatening.The most common heart infections are caused by bacteria, though fungal infections can also occur.Prosthetic (replaced) or repaired heart valves are prone to infection.Growths of infectious tissue on heart valves are called vegetations and can lead to strokes due to pieces of tissue breaking off (called emboli) and blocking blood vessels in the brain.The March 28, 2007, issue of JAMA includes an article on infections of prosthetic heart valves.
The rational clinical examination. Does this dizzy patient have a serious form of vertigo?
Authors: D. A. Froehling
Journal: JAMA (1994)

<h3>CLINICAL SCENARIOS: COMMON CAUSES OF VERTIGO</h3><h3>Patient 1</h3> A 52-year-old woman was admitted to the hospital because of nausea, a constant spinning sensation, and vomiting of 24 hours' duration. Any movement of her head made these symptoms worse. On examination, she had bilateral horizontal spontaneous nystagmus. Two days later, after symptomatic improvement, she was dismissed. At follow-up 2 weeks later, her symptoms and nystagmus had completely resolved. <h3>Patient 2</h3> A 70-year-old woman had a 4-month history of an intermittent whirling sensation when turning her head and especially when rolling over in bed. On examination, a left-side-down head-hanging maneuver elicited rotatory nystagmus, with the fast component to the left ear (Figure). There was a latency of about 3 seconds before the onset of nystagmus, which lasted approximately 10 seconds. <h3>WHY EVALUATE VERTIGO?</h3> "Vertigo" is defined in Webster's dictionary<sup>2</sup>as a disturbance "in which the external world seems to revolve around
Immune dysregulation in the aging human lung.
Authors: K C Meyer, W Ershler, N S Rosenthal, X G Lu, K Peterson
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Aging has been associated with diminished lung function and increased susceptibility to lung infection. To determine whether changes suggestive of immune dysregulation and inflammation appear in the lungs of clinically normal individuals as a function of advancing age, we performed bronchoalveolar lavage (BAL) on discontinuous age groups (20-36, 45-55, and 65-78 yr old) of clinically normal volunteer subjects. We measured immunoglobulin (IgG, IgA, IgM), albumin, interleukin-6 (IL-6), and interleukin-10 concentrations in BAL fluid. Bronchoalveolar cell profiles, cell surface antigen expression, and superoxide anion production were also measured. A significant increase in total cell concentration, neutrophils, and BAL immunoglobulin content was observed in the oldest age group compared with the youngest age group. Mean lymphocyte subset (CD4+/CD8+) ratios were significantly increased in blood (2.6 +/- 0.4 versus 1.6 +/- 0.1; p<0.03) and to a greater degree in BAL (4.8 +/- 1.0 versus 1.9 +/- 0.2; p<0.01) for the oldest versus youngest age groups. Similarly, BAL-derived cells displayed significantly increased phorbol myristate acetate-stimulated release of superoxide anion (8.8 +/- 1.3 versus 4.5 +/- 0.7 nmol/5 x 10 5 cells/h; p<0.01) for the oldest versus youngest subject group, and mean BAL IL-6 concentrations were significantly elevated in the oldest age group (0.86 +/- 0.13 ng/ml) compared with the youngest age group (0.53 +/- 0.03 ng/ml; p<0.01). Our observations suggest that altered inflammatory cell profiles and low-grade inflammation exist in the lower respiratory tracts of many asymptomatic, clinically normal volunteers of advanced age.
Expression of the cardiac ryanodine receptor in the compensated phase of hypertrophy in rat heart
Authors: F Rannou
Journal: Cardiovascular Research (1996)

Abnormal calcium handling is a general feature of cardiac hypertrophy and alteration in the expression of SR proteins has been suggested to be involved in this alteration. To determine the expression of the cardiac ryanodine receptor (Ry2) gene during compensatory hypertrophy, we studied the mRNA and protein accumulation in left ventricles from rats with 30 to 100% hypertrophy.Cardiac hypertrophy was obtained after 1 month of aortic constriction. Ry2 mRNA was analyzed by RNase protection assay, Northern and slot blots, and Ry2 protein by high-affinity [3H]ryanodine binding and Western blot.We demonstrate that: (1) the cardiac Ry2 mRNA concentration is decreased by 50% in severe hypertrophy; (2) both the density of the high-affinity sites and the Ry2 protein level are decreased by 25%; (3) the decrease in the mRNA and protein levels and the number of high-affinity sites are highly correlated to the severity of hypertrophy.Our results suggest that, as for SR Ca(2+)-ATPase, there is either a downregulation or a lack of upregulation of the gene coding for the Ry2 in compensatory hypertrophy. The decreased density of Ry2 may alter SR Ca2+ transport and contribute to the impaired Ca2+ handling by slowing the Ca2+ movements.
Occupational exposures to Cd, Ni, and Cr modulate titers of antioxidized DNA base autoantibodies.
Authors: K Frenkel, J Karkoszka, B Cohen, B Barański, M Jakubowski, G Cosma, E Taioli, P Toniolo
Journal: Environmental Health Perspectives (1994)

This study was undertaken to establish whether occupational exposures to derivatives of carcinogenic metals evoke inflammatory immune responses, as determined by the presence of elevated titers of antibodies (Ab) that recognize oxidized DNA bases. Sera obtained from the blood of steel welders (Delaware) and from workers of the Centra Ni-Cd Battery Factory (Poznań, Poland) were analyzed by the enzyme-linked immunosorbent assay. To determine specific and nonspecific binding, an oxidized thymidine [5-hydroxymethyl-2'-deoxyuridine (HMdU)] coupled to bovine serum albumin (HMdU-BSA) as well as mock-coupled BSA (M-BSA) were used as antigens for coating the wells of microtiter plates. Titers of anti-HMdU Ab were significantly elevated in the high Cd and Ni exposure groups (18.3 +/- 3.2 vs 10.8 +/- 2.1 A492/microliters; p < 0.05). The sera of the groups with low exposures to Cd and Ni also had enhanced titers of those Ab but those increases were not statistically significant. Interestingly, the Ab titers present in the sera of controls for Cd and Ni exposures appear to be constant regardless of the protein content. In contrast, both lightly and heavily exposed subjects exhibited Ab titers that increased with increasing protein content. When 12 randomly selected workers (4 from each of the control, lightly, and heavily exposed groups) were outfitted with personal monitors, anti-HMdU Ab titers of those workers showed a significant difference between the groups with light (< 100 micrograms/m3) and heavy (> 200 micrograms/m3) exposures to Cd (9.8 +/- 3.7 vs 22.1 +/- 3.7 A492/microliters; p < 0.01) and Ni (11.7 +/- 1.4 vs 31.0 +/- 1.8; p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
Cholecystokinin provocation tests
Authors: A W MAJEED, A G JOHNSON
Journal: Gut (1999)

cacy of combining these drugs might be of great help.Presently, the data in the three meta-analyses constitutes a sound, objective basis on which to tackle therapeutic decisions.The statement endorsed by the working party seems to reflect the common belief shared by leading authorities in this field that these agents are ineVective in the treatment of acute pancreatitis.This may be because the drugs are believed to act through their antisecretory or protease inhibitory activity.However, other relevant properties of somatostatin and octreotide, namely the haemodynamic eVects on reducing splanchnic blood flow, the stimulation of the hepatic reticuloendothelial system, and the modulation of the cytokine cascade, are usually forgotten.It has been hypothesised that the eYcacy of somatostatin and octreotide in acute pancreatitis might be better explained by all these properties rather than its capability of inhibiting pancreatic secretion.
Procedures on dying patients are wrong, study concludes
Authors: J. Ciment
Journal: BMJ (2000)

The practice of allowing trainee doctors to acquire skills by carrying out procedures on dying patients has been challenged by doctors in the United States, who claim that it is an unacceptable departure from the normal system of requiring informed consent. Moreover, many trainee doctors themselves are opposed to carrying out certain of the procedures, the doctors say.

The authors of the study, whose results were published in the New England Journal of Medicine (1999;341:2088-91), asked 234 trainee doctors in Conncticut to consider the following scenario: an elderly inpatient is receiving cardiopulmonary resuscitation; after 20 minutes there is no response from the patient, who seems to be dying. The doctors were asked whether they felt it was ever appropriate in such a situation for a …
Management of the Potentially Infected Obstetric Case
Authors: Edward G. Waters
Journal: New England Journal of Medicine (1949)

THE problem of potential infection in obstetrics is not new. Adam was the first man to attend a patient with potential infection in childbirth, and threat of infection is still the obstetrician's thankless heritage. Sepsis, which has been the leading cause of childbed death through incalculable ages, was uncontrolled until the first glimmering hopes were stirred by Alexander Gordon, Oliver Wendell Holmes, Charles White, of Manchester, and Ignaz Semmelweis.When one considers the seemingly heroic efforts now required to reduce death rates by even 1 per cent, it is awesome to contemplate how the application of the simple principles enunciated . . .
Open access gastroscopy: too much to swallow?
Authors: D D Kerrigan, S R Brown, G H Hutchinson
Journal: BMJ (1990)

To ascertain the proportion of endoscopic examinations with normal findings in patients referred for gastroscopy through hospital medical staff or directly by their general practitioner and to assess the likely effect of targeting endoscopy in older patients.Retrospective audit of the gastroscopy practice of one consultant from 1986 to 1988 from information recorded on a standard form completed at the time of the examination, which contained details of patients, their endoscopic findings, and mode of referral (open access or clinic).One district general hospital.1545 Consecutive patients from primary catchment area attending for their first gastroscopy; 454 were referred through the outpatient clinic or by hospital colleagues (clinic group) and 1091 were accepted for endoscopy solely on their general practitioner's clinical diagnosis (open access group).Similar numbers (about 40%) of examinations with normal findings were performed in each group, although in patients aged over 40 the proportion with normal findings was significantly higher in the clinic group (p less than 0.03). Endoscopic evidence of gastro-oesophageal reflux disease, peptic ulceration, and gastroduodenal inflammation was equally common in each group; upper gastrointestinal malignancy, however, was significantly more common in patients referred through hospital doctors (5%, 23/454 v 2%, 22/1091 respectively; p less than 0.005) (although many of these patients had already been extensively investigated).Open access gastroscopy does not increase the number of unnecessary examinations and should become more widely available. Targeting this service to patients aged over 40 would reduce the number of requests but increase the diagnostic yield.
The Physiology of Gastric Acid Secretion
Authors: Franklin H. Epstein, M. Michael Wolfe, Andrew H. Soll
Journal: New England Journal of Medicine (1988)

THE mammalian stomach is a specialized organ of the digestive tract that serves to store and process food for absorption by the intestine.1 One of its features, considered to be the hallmark of gastric function, is the ability to secrete acid; however, the precise function of gastric acid is not completely understood. As hydrogen ions are secreted and intragastric pH decreases to less than 3.5, the conversion of the zymogen pepsinogen to active proteolytic pepsin enzymes is facilitated. Although it is generally assumed that acid and pepsin are required for the hydrolysis of proteins and other foods, persons with achlorhydria . . .
Despite Finding Anthrax Vaccine Useful, IOM Recommends Seeking a Better One
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Positive Indium-111 Leukocyte Scintigraphy in Vaginitis
Authors: DONALD W. TAYLOR, DANIEL J. WALZ, WILLIAM I. BABCHUK, KENNETH D. McGINNIS
Journal: Clinical Nuclear Medicine (1987)

Leukocytes labeled with Indium-111 were found in vaginal discharge of a patient with vaginitis while scanning for pelvic abscess. The scintigram mimicked a pelvic abscess and the nuclear medicine physician should be alert to this possibility.
A modified double dye injection method for pulmonary blood volume determination. II. Results in resting and exercising normal subjects
Authors: A. LOCKHART, P. DUHAZE, J . POLIANSKI, D . WEILL, J . MENSCH-DECHENE
Journal: Cardiovascular Research (1974)

Journal Article A modified double dye injection method for pulmonary blood volume determination. II. Results in resting and exercising normal subjects Get access A. LOCKHART, A. LOCKHART 1 From the Départment de Physiologie Humaine, Laboratoire d'Exploration Fonctionnelle, Hôpital du Kremlin-Bicêtre, 94270, France 1Address for reprints: Dr. A. Lockhar, Département de Physiologie Humaine, Université Paris-Sud, 6, rue Albert Bayet 75013–Paris, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar P. DUHAZE, P. DUHAZE From the Départment de Physiologie Humaine, Laboratoire d'Exploration Fonctionnelle, Hôpital du Kremlin-Bicêtre, 94270, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J . POLIANSKI, J . POLIANSKI From the Départment de Physiologie Humaine, Laboratoire d'Exploration Fonctionnelle, Hôpital du Kremlin-Bicêtre, 94270, France Search for other works by this author on: Oxford Academic PubMed Google Scholar D . WEILL, D . WEILL From the Départment de Physiologie Humaine, Laboratoire d'Exploration Fonctionnelle, Hôpital du Kremlin-Bicêtre, 94270, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J . MENSCH-DECHENE J . MENSCH-DECHENE From the Départment de Physiologie Humaine, Laboratoire d'Exploration Fonctionnelle, Hôpital du Kremlin-Bicêtre, 94270, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 8, Issue 1, January 1974, Pages 120–131, https://doi.org/10.1093/cvr/8.1.120 Published: 01 January 1974
Cocoa Intake and Blood Pressure
Authors: Dimitrios Tsikas, Ranieri Rossi
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal