tbuckley/cabot-search huggingface dataset:
Abstract 3324: Evidence for label-retaining tumor initiating cells in human glioblastoma
Authors: Loic P. deleyrolle, Angus Harding, Kathleen Cato, Florian Siebzehnrubl, Maryam Rahman, Denis de Assis, Hassan Azari, Sarah Olson, Brian Gabrielli, Geoffrey Osborne, Angelo Vescovi, Brent Reynolds
Journal: Cancer Research (2011)

Abstract Individual tumor cells display diverse functional behaviors in terms of proliferation rate, cell-cell interactions, metastatic potential and sensitivity to therapy. Moreover, sequencing studies have demonstrated surprising levels of genetic diversity between individual patient tumors of the same type. Tumor heterogeneity presents a significant therapeutic challenge as diverse cell-types within a tumor can respond differently to therapies, and inter-patient heterogeneity may prevent the development of general treatments for cancer. One strategy that may help overcome tumor heterogeneity is the identification of tumor subpopulations that drive specific disease pathologies for the development of therapies targeting these clinically relevant subpopulations. Here we have identified a dye-retaining brain tumor population that displays all the hallmarks of a tumor-initiating subpopulation. Using a limiting dilution transplantation assay in immuno-compromised mice, label-retaining brain tumor cells display elevated tumor initiation properties relative to the bulk population. Importantly, tumors generated from these label-retaining cells exhibit all the pathological features of the primary disease. Together, these findings confirm dye-retaining brain tumor cells as drivers of tumor initiation and therefore viable targets for the development of therapeutics targeting this subpopulation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3324. doi:10.1158/1538-7445.AM2011-3324
Macroangiopathic Hemolytic Anemia Due to Congenital Cardiovascular Anomalies
Authors: Robert G. Westphal, Edwin A. Azen
Journal: JAMA (1971)

Hemolytic anemia due to vascular trauma occurred in a boy with congenital cardiovascular anomalies that included aortic coarctation and bicuspid aortic valve. Turbulent stress of red blood cells passing through deformed orifices is deemed responsible for the traumatic damage and ensuing hemolysis in this patient.
Spermicides and Birth Defects-Reply
Authors: Hershel Jick
Journal: JAMA (1982)

<h3>In Reply.—</h3> Dr Denniston presents an interesting suggestion to explain an association between spermicide use and unfavorable outcome of pregnancy. He is, however, incorrect in stating that the associated malformations found in our study were "random." The increased rates of malformation in the spermicide group were restricted to a few uncommon disorders. There was no association with congenital heart disease, cleft palate, and the other malformations studied.
A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature
Authors: Hui Jin, Aparna Aiyer, Jingmei Su, Per Borgstrom, Dwayne Stupack, Martin Friedlander, Judy Varner
Journal: Journal of Clinical Investigation (2006)

CD34+ bone marrow-derived progenitor cells contribute to tissue repair by differentiating into endothelial cells, vascular smooth muscle cells, hematopoietic cells, and possibly other cell types. However, the mechanisms by which circulating progenitor cells home to remodeling tissues remain unclear. Here we show that integrin alpha4beta1 (VLA-4) promotes the homing of circulating progenitor cells to the alpha4beta1 ligands VCAM and cellular fibronectin, which are expressed on actively remodeling neovasculature. Progenitor cells, which express integrin alpha4beta1, homed to sites of active tumor neovascularization but not to normal nonimmune tissues. Antagonists of integrin alpha4beta1, but not other integrins, blocked the adhesion of these cells to endothelia in vitro and in vivo as well as their homing to neovasculature and outgrowth into differentiated cell types. These studies describe an adhesion event that facilitates the homing of progenitor cells to the neovasculature.
Pharmacologic Paralysis and Withdrawal of Mechanical Ventilation at the End of Life
Authors: R D Truog, J P Burns, C Mitchell, J Johnson, W Robinson
Journal: New England Journal of Medicine (2000)

The right of a patient or surrogate to refuse life-sustaining treatment, including mechanical ventilation, is firmly established in American law and bioethics.1 Moreover, practice standards now encourage clinicians to administer sedatives and analgesics in doses that fully relieve the pain and suffering of terminally ill patients, including patients from whom life support is being withdrawn.2 In addition to receiving these medications, however, some patients from whom mechanical ventilation is being withdrawn have been receiving or are given neuromuscular blocking agents at the time of death. By blocking neuromuscular transmission, these agents cause paralysis until they are metabolized or their action . . .
Beta versus gamma radiation for treatment of in-stent restenosis: angiographic predictors and outcomes in 630 patients
Authors: Kazuyuki Shirai, Alexandra J. Lansky, Roxana Mehran, Kartik Desai, Costantino Costantini-Ortiz, Brian Proctor, Teraza Conway, Martin Fahy, Nishe Dave, Izat Hjazi, George Dangas, Gregg W. Stone, Paul Teirstein, Jeffrey Moses, Martin B. Leon
Journal: Journal of the American College of Cardiology (2002)
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
Authors: Pippa Newell, Sara Toffanin, Augusto Villanueva, Derek Y. Chiang, Beatriz Minguez, Laia Cabellos, Radoslav Savic, Yujin Hoshida, Kiat Hon Lim, Pedro Melgar-Lesmes, Steven Yea, Judit Peix, Kemal Deniz, M. Isabel Fiel, Swan Thung, Clara Alsinet, Victoria Tovar, Vincenzo Mazzaferro, Jordi Bruix, Sasan Roayaie, Myron Schwartz, Scott L. Friedman, Josep M. Llovet
Journal: Journal of Hepatology (2009)
Inhalation and Skin Tests with Extracts of Hay and Fungi in Patients with Farmer's Lung
Authors: J. V. Williams
Journal: Thorax (1963)

Farmer's lung is a specific respiratory illness which results from the inhalation of mouldy hay, grain, straw, or other similar vegetable matter.Hay becomes mouldy if it is harvested and stored wet.Fungi and bacteria multiply in it, fermentation occurs, and heat is produced.When dry, the mouldy hay is partly converted to a fine dust.The illness was described by Campbell in 1932 and later by Fawcitt (1936a and b, 1938a and b), Fuller (1953), Studdert (1953( ), Frank (1958)), and Dickie and Rankin (1958).It is fairly common in Britain (Staines and Forman, 1961).Acute, subacute, and chronic phases of the illness have been described by Fuller (1953).The acute illness is characterized by dyspnoea, cough, fever, malaise, cyanosis, basal crepitations, and later diffuse reticulo-nodular chest radiographic shadowing.The pulmonary histological changes consist of a granulomatous infiltration of the interstitial tissues with no evidence of bacterial or fungal proliferation.Later pulmonary fibrosis, distortion of the bronchioles, and emphysema occur (Fuller, 1953 and 1958; Frank, 1958; Dickie and Rankin, 1958;Totten, Reid, Davis, and Moran, 1958;Seal, 1962).The acute symptoms which occur after exposure to mouldy hay have been attributed to a broncho- mycosis (Fawcitt, 1936a and b; Tornell, 1946), mechanical blockage of the pulmonary airways by the swelling or germination of fungal spores (Williams and Mulhall, 1956; Pickworth, 1961), non-specific pulmonary irritation (Studdert, 1953), the toxic effect of a mould in a non-allergic person (Frankland and Hamilton, 1958), a hypersensitivity reaction to fungi or their products (Fawcitt, 1938a and b; Dickie and Rankin, 1958; Cooper and Greenaway, 1961), the physical, chemical, or immunological properties of the fine degraded hay fibre which has been acted on by the mouldy hay microflora (Duncan, 1945), and the inhalation of bacterial endotoxins (Pernis, Vigliani, Cavagna, and Finueli, 1961).This report describes skin and inhalation tests with crude hay and extracts of hay and fungi on on July 19, 2023 by guest.
Patterns of Drug Abuse Among Military Inductees
Authors: JOHN P. CALLAN, CARROLL D. PATTERSON
Journal: American Journal of Psychiatry (1973)

A questionnaire concerning drug abuse was administered to 19,948 new military inductees over a six-month period. Almost one-third of the subjects had used drugs, but most were casual users. Marijuana and hashish were most frequently used. There were higher rates of use among college dropouts and men from unstable families, urban areas, and families with high incomes. There was little racial difference in overall drug use. However, non-whites used amphetamines, barbiturates, and heroin twice as much as whites, while whites tended to use marijuana, hashish, and hallucinogens.
Keeping Personal Health Information Safe
Authors: David Blumenthal, Deven McGraw
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paradoxical Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular Adrenocortical Disease
Authors: Constantine A. Stratakis, Nicholas Sarlis, Lawrence S. Kirschner, J. Aidan Carney, John L. Doppman, Lynnette K. Nieman, George P. Chrousos, Dimitris A. Papanicolaou
Journal: Annals of Internal Medicine (1999)

Background: Primary pigmented nodular adrenocortical disease causes the Cushing syndrome in children and young adults and is most frequently associated with the Carney complex. Objective: To evaluate diagnostic tests for primary pigmented nodular adrenocortical disease. Design: Retrospective cohort study. Setting: Tertiary care center. Patients: 21 patients with primary pigmented nodular adrenocortical disease. The control groups consisted of 9 patients with macronodular adrenocortical disease and 15 patients with primary unilateral adrenocortical disease (single adenomas). Measurements: Clinical characteristics, radiologic imaging, and a 6-day Liddle test with determination of urinary free cortisol and 17-hydroxycorticosteroid excretion. Results: Adrenal imaging and other tests were of limited value for the diagnosis of primary pigmented nodular adrenocortical disease. The Liddle test, however, distinguished patients with this disorder from those with other primary adrenocortical lesions. An increase of 50% or more in urinary free cortisol levels on day 6 of the Liddle test identified 9 of 13 patients (69.2% [95% CI, 46.6% to 91.8%]) with primary pigmented nodular adrenocortical disease, excluded all patients with macronodular adrenocortical disease, and was present in only 3 of the 15 patients with single adrenocortical adenomas (20% [CI, 0% to 40.2%]). An increase in urinary free cortisol excretion of 100% or more on day 6 of the Liddle test identified only patients with primary pigmented nodular adrenocortical disease. Conclusions: Patients with primary pigmented nodular adrenocortical disease responded to dexamethasone with a paradoxical increase in glucocorticoid excretion during the Liddle test. This feature distinguishes such patients from those who have the Cushing syndrome caused by other primary adrenal disorders and may lead to timely detection of the Carney complex (a potentially fatal disorder) in asymptomatic patients.
The grand plan
Authors: G Hutchison
Journal: BMJ (1994)

The life of a college examiner (for any college) is not easy. I understand this, now, as I stroll the broad, sunny uplands which lie between postgraduate qualification and presenile dementia. As an examination candidate, my main impression was that examiners were simply perverse to the point of madness. Now, though, I believe that I can imagine how these things come about.

As the day drags on, the weary examiner becomes dissatisfied with the humdrum rhythm of straightforward question and routine answer. A higher goal glimmers before the mind's eye. A grand plan is formulated. The examiner will, by …
Efficacy of apraclonidine 1% versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty
Authors: Jianming Ren, Dong H Shin, Hak S Chung, Catherine M Birt, Bernice K Glover, Mark S Juzych, Bret A Hughes, Chaesik Kim
Journal: Ophthalmology (1999)
Effect of acid in the duodenum on histamine-stimulated gastric secretion in man
Authors: D. Johnston, H. L. Duthie
Journal: Gut (1964)

EDITORIAL SYNOPSIS In normal subjects, the secretion of gastric juice in response to a constant intravenous infusion of histamine in near maximal dosage diminished when N/10 hydrochloric acid was infused into the proximal duodenum.In patients with duodenal ulcer the secretion of gastric juice was inhibited when submaximal doses of histamine were used but to a lesser degree than in the normal subjects.When the histamine stimulus was nearly maximal, no inhibition was found in the patients with duodenal ulcer.on November 22,
hTERT mRNA levels by real-time RT-PCR in acute myelogenous leukemia
Authors: Hee Jin Huh, Jung Won Huh, Eun Sun Yoo, Chu Myong Seong, Miae Lee, Ki Sook Hong, Wha Soon Chung
Journal: American Journal of Hematology (2005)

The purpose of this study was to investigate whether levels of hTERT mRNA, as determined by real-time RT-PCR, are associated with prognosis and clinical course in AML patients. Fifty-four bone marrow specimens from 21 patients diagnosed with de-novo AML were included. The level of hTERT mRNA was measured with the Telo TAGGG hTERT Quantification Kit (Roche Diagnostics, Mannheim, Germany), using a LightCycler Instrument (Roche Diagnostics). The level of hTERT mRNA was determined as the relative ratio (RR), which was calculated by dividing the level of hTERT mRNA by the level of the porphobilinogen deaminase (PBGD) housekeeping gene in the same samples [1,000 × (hTERT/PBGD)]. The expression rates of hTERT mRNA were significantly higher at diagnosis (73%) and during relapse (80%) than during remission (27%) (P < 0.05). The median RR for diagnosis or relapse was significantly higher than that for patients in remission (P < 0.05). hTERT mRNA expression was not correlated with CD34 expression, blast counts, white blood cell counts, or chromosomal abnormality (P > 0.05). Two patients who showed hTERT mRNA expression during remission (RR 3.14 and 7.15, respectively) relapsed after 1 month. Among seven patients with high hTERT mRNA levels (RR > 9.51), 4 failed to achieve complete remission (CR), whereas 4 of 5 patients without hTERT mRNA expression at diagnosis or during relapse achieved CR (P > 0.05). Patients showing a trend of increasing hTERT mRNA levels failed to reach a second CR after relapse, while those with a trend toward decreasing hTERT mRNA did achieve CR. Among eight samples showing hTERT mRNA expression in remission (RR > 0), 5 were obtained from patients who had received GCSF within 14 days. The expression rate and level of hTERT mRNA during remission were significantly higher in patients who had previously received GSCF (56%, RR = 0.15) than in other patients (15%, RR = 0) (P < 0.05). Serial and quantitative analysis of hTERT mRNA may be a useful marker for prediction of prognosis and monitoring in AML patients. Am. J. Hematol. 79:267–273, 2005.© 2005 Wiley-Liss, Inc.
The Discrepancy between Observational Studies and Randomized Trials of Menopausal Hormone Therapy: Did Expectations Shape Experience?
Authors: Nananda F. Col, Stephen G. Pauker
Journal: Annals of Internal Medicine (2003)

Differences between observational and randomized studies of the effects of menopausal hormone therapy (HT) on coronary heart disease (CHD) have been attributed to the fact that women who choose to use HT tend to be healthier than those who do not. Although this bias should affect all clinical outcomes with modifiable risk factors, estimates for stroke and pulmonary embolism were unaffected. The authors sought possible explanations for this isolated discrepancy in CHD findings. Unlike the randomized Women's Health Initiative (WHI) trial, the observational Nurses' Health Study (NHS) did not try to detect silent myocardial infarctions. Many women present with atypical ischemic symptoms. Hormone therapy users who believe that HT reduces CHD risks might not interpret ischemic symptoms as related to CHD, might not seek medical attention, and might present differently to their physicians, all of which could lead to more unrecognized myocardial infarctions among HT users in the NHS. In addition, persons completing death certificates and NHS physicians interpreting death certificates were not blinded to the use of HT. If persons assigning cause of death knew the patient had used HT and believed that HT prevented CHD, they might have been more likely to assign a condition other than CHD as the cause of death. If HT users were 20% less likely to have their infarctions recognized and their deaths attributed to CHD, a true increase in CHD due to HT use would appear to be a reduction in CHD. Combining these reporting biases with socioeconomic differences between users and nonusers could explain discrepancies. Beliefs held by patients, clinicians, and investigators might have affected the ascertainment of CHD outcomes in observational studies.
Optimal endpoint for drug-eluting stent: predictive value of minimum stent area for long-term stent patency
Authors: Yasuhiro Honda, Eberhard Grube, Toru Kataoka, Karl E. Hauptmann, Yoshihiro Morino, Seung-Ho Hur, Paul G. Yock, Peter J. Fitzgerald
Journal: Journal of the American College of Cardiology (2002)
Regionalized Perinatal Care Systems and Very Low-Birth-Weight and Very Preterm Infants
Authors: Lex W. Doyle
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiopulmonary Complications During Gastroscopy in Patients with Chronic Respiratory Failure Undergoing Long-Term Home Oxygen Therapy
Authors: M. Fujimura, Y. Ishiura, S. Myou, T. Amemiya, S. Sasaki, T. Matsuda
Journal: Endoscopy (2002)

Gastric ulcer and hemorrhage are major complications in patients with chronic respiratory failure, but upper GI endoscopy tends to be avoided because of possible cardiopulmonary events. This study was designed to evaluate hypoxemia and subsequent cardiac complications during gastroscopic procedures in patients with chronic respiratory failure undergoing long-term home oxygen therapy (LHOT).Gastroscopy was carried out in 10 patients undergoing LHOT and 10 age-matched control subjects without pulmonary diseases. Oxygen saturation and cardiac arrhythmias before and during gastroscopy were monitored. Patients were given 10 mg intramuscular scopolamine butylbromide and local anesthesia using 100-300 mg lidocaine gel 15 minutes before the procedure. Each patient continued to receive oxygen via a nasal cannula in the same dosage as their daily use.Decrease in oxygen saturation during endoscopic procedure was significantly greater in patients undergoing LHOT (from 95.9+/-0.9 to 93.4+/-1.7%) compared with control subjects (from 96.7+/-0.4 to 96.2+/-0.4%). There was a significant correlation between the degree of hypoxemia and the oxygen dosage required for their daily treatment in the patients (r = 0.727, P<0.02).These results indicate that the degree of respiratory failure influences the degree of decrease in oxygen saturation during gastroscopy. It is suggested that use of the nasal route for oxygen supply may be one of the major causes of the hypoxemia.
Life at the Duke of Singapore
Authors: Karen Honey
Journal: Journal of Clinical Investigation (2009)

Duke University, Durham, North Carolina, USA, and the National University of Singapore (NUS) formally formed a partnership in 2005 to establish a new medical school (Duke-NUS Graduate Medical School, herein referred to as Duke-NUS) (Figure ​(Figure1).1). The school is based in Singapore and, while it is formally part of the NUS system, it is distinct in that it has an independent governing board that includes representatives of Duke University. The students, the first of whom matriculated in August 2007, learn from a curriculum based on that of Duke University School of Medicine and upon successful completion of the course, they will be awarded a joint Doctor of Medicine (MD) degree from both Duke University and the NUS.
(44) Porokeratosis striata of Nekam
Authors: B.E. Monk, A.C. Pembroke
Journal: British Journal of Dermatology (1985)

Journal Article (44) Porokeratosis striata of Nékám Get access B.E. Monk, B.E. Monk King's College Hospital, London SE5 Search for other works by this author on: Oxford Academic Google Scholar A.C. Pembroke A.C. Pembroke King's College Hospital, London SE5 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 90–91, https://doi.org/10.1111/j.1365-2133.1985.tb13059.x Published: 01 July 1985
Klaus Fuchs: The Man Who Stole the Atom Bomb
Authors: Jane M. Orient
Journal: JAMA (1988)

Klaus Fuchs alone influenced the safety of more people, and accomplished greater damage, than any other spy in the history of nations, according to the April 1951 report of the Joint Congressional Committee on Atomic Espionage. Fuchs died Jan 28, 1988, at the age of 76. At Los Alamos, Fuchs impressed Oppenheimer with his ability to demonstrate that the group was approaching a problem from the wrong angle. Thus, he was invited to the weekly colloquia and became familiar with all aspects of the Manhattan Project. His meticulous reports to the USSR, which he carried to an agent in Santa Fe on the seat of his car, probably enabled the Soviets to detonate an atomic bomb from one to two years earlier than otherwise possible. After returning to his adopted home, Fuchs gained a position of trust at Harwell, a British center of research on atomic weapons and energy. He