tbuckley/cabot-search huggingface dataset:
Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate
Authors: C. P. LAU, A. R FREEDMAN, S. FLEMING, M. MALIK, A J. CAMM, D. E WARD
Journal: Cardiovascular Research (1988)

Journal Article Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate Get access CHU PAK LAU, CHU PAK LAU From the Department of Cardiological Sciences, St George's Hospital Medical School, London Search for other works by this author on: Oxford Academic PubMed Google Scholar ANDREW R FREEDMAN, ANDREW R FREEDMAN From the Department of Cardiological Sciences, St George's Hospital Medical School, London Search for other works by this author on: Oxford Academic PubMed Google Scholar SIMON FLEMING, SIMON FLEMING From the Department of Cardiological Sciences, St George's Hospital Medical School, London Search for other works by this author on: Oxford Academic PubMed Google Scholar MAREK MALIK, MAREK MALIK From the Department of Cardiological Sciences, St George's Hospital Medical School, London Search for other works by this author on: Oxford Academic PubMed Google Scholar A JOHN CAMM, A JOHN CAMM From the Department of Cardiological Sciences, St George's Hospital Medical School, London Search for other works by this author on: Oxford Academic PubMed Google Scholar DAVID E WARD DAVID E WARD From the Department of Cardiological Sciences, St George's Hospital Medical School, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 22, Issue 1, January 1988, Pages 67–72, https://doi.org/10.1093/cvr/22.1.67 Published: 01 January 1988 Article history Received: 06 March 1987 Accepted: 27 July 1987 Published: 01 January 1988
Red-cell Aplasia in Marasmus and Kwashiorkor
Authors: A. Kondi, S. H. Mehta, H. Foy
Journal: BMJ (1962)

MEBRrThere is a wide normal variation in the cord haemoglobin level, and it can be affected by factors other than haemolysis.The lower part of this normal range is below 15 g.1 Therefore some mildly affected infants may have haemoglobin below 15 g.yet not need exchange transfusion.My clinical impression is that between 5 and 10% of affected infants have a cord haemoglobin below 15 g. and bilirubin below 2.6 mg.In addition, if the present criteria are followed strictly a very low percentage of affected infants seem to be left untreated, and the decision never, in my experience, has to be reversed.One would feel more sure that the minimum number of unnecessary exchanges were being done if an occasional infant initially left untreated proved to need an exchange in the end.For these reasons, I wonder if it is justifiable at least to observe the mature infants of birth weight over 6 lb.(2.7 kg.) with cord bilirubin less than 2.6 mg., and, possibly, go further and do immediate exchange for bilirubin 5 mg.or more, and elective exchange for 2.6-4.9 mg., altering the criteria in the light of experience.-Iam, etc.,
Endoscopic stone removal using a scissors papillotome followed by papillary balloon dilation in patients with Billroth II gastrectomy – a case series
Authors: H. Choi, J. Moon, B. Ko, Y. Kim, Y. Cheon, Y. Cho, M. Lee, C. Shim
Journal: Endoscopy (2009)

The endoscopic removal of bile duct stones in patients with a previous Billroth II gastrectomy involves several obstacles in the approach to the ampulla of Vater, with selective cannulation and endoscopic sphincterotomy (EST) required for stone removal. EST in patients with a Billroth II gastrectomy remains a challenge to the biliary endoscopist because of technical difficulties and the fear of associated complications [1] [2] [3] [4] [5] [6].
430 A ROLE FOR VITAMIN A IN THE REGULATION OF HEPATIC IGF-I SECRETION
Authors: V.I.C. Custodio, C.E. Martinelli, R.J. Custodio, I.S. Ferraz, L.A. Del Ciampo, R.G. Ricco, H. Vannucchi, J.C. Daneluzzi, A.L.C. Martinelli
Journal: Journal of Hepatology (2009)
Nicotine Scores Again: In-Hospital Withdrawal
Authors: Raja I. Zabaneh
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Nicotine addiction is the most common of all substance dependencies, incurring enormous medical, social, and psychological costs. Recent technological advances, such as the advent of transdermal nicotine patches, have broadened the strategies for nicotine replacement in highly dependent smokers and may aid in cigarette smoking cessation.<sup>1</sup>Herein we describe a patient in whom the high dependence on nicotine almost resulted in a fatal catastrophe. A 36-year-old man with a medical history of Alport's disease, cadaveric renal transplant a year prior to admission, and longstanding nicotine dependency was admitted to a smoke-free hospital with acute cholecystitis. Having been treated with intravenous antibiotics and hydration, the patient then underwent an uneventful cholecystectomy. After the operation, he was given 2 L of oxygen per minute via a nasal cannula. A day later, the patient was irritable, anxious, and restless, and he requested permission to smoke cigarettes. His request was
The J-Curve Phenomenon and the Treatment of Hypertension
Authors: Stephen MacMahon
Journal: JAMA (1991)

To the Editor.  — In their review of data from some nonrandomized studies of patients receiving antihypertensive drug treatment, Farnett et al1concluded that reducing blood pressure to conventional levels (70 to 90 mm Hg)... may be deleterious in precipitating cardiac events, particularly in patients with known cardiac disease. However, like Cruickshank et al,2who have made the same suggestion, Farnett et al failed to take adequate account of the confounding of such nonrandomized analyses by the effects of underlying cardiac disease on both prognosis and blood pressure (BP). For example, left ventricular dysfunction (whether conferred by coronary disease or left ventricular hypertrophy) will increase the risk of death and will, independently, cause a lowering of BP. Hence, in patients with cardiac disease, a low BP may indicate a poor prognosis, but this should not be interpreted as evidence of an adverse effect of low BP on outcome.
Hazard of Mammography
Authors: WINTHROP FISH
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 April 1976Hazard of MammographyWINTHROP FISH, M.D., F.A.C.P.WINTHROP FISH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-4-500_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: With regard to Dr. Bailar's article on mammography (Ann Intern Med 84:77-84, 1976), there would seem to exist another hazard that he did not mention, nor have I seen it considered elsewhere.Those of us who have had no occasion to experience mammography may be unaware that in the process, the suspicious bosom is subjected to a substantial squeeze. It even sometimes hurts. Having been raised in a school that handles cancers gently lest dissemination occur, I have therefore become nervous about mammography.It is about time for a study on the relapse rate and timing of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Providence Professional Building 3300 Providence Drive, Suite 211 Anchorage, Alaska 99504 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1976Volume 84, Issue 4Page: 500-500KeywordsMammography Issue Published: 1 April 1976 PDF downloadLoading ...
Reviews, Notes, and Listings: Hematology: Disorders of Thrombosis and Hemostasis: Clinical and Laboratory Practice
Authors: Jeffrey I. Weitz
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 February 1993Reviews, Notes, and Listings: Hematology: Disorders of Thrombosis and Hemostasis: Clinical and Laboratory PracticeJeffrey I. Weitz, MDJeffrey I. Weitz, MDMcMaster University and Hamilton Civic Hospitals Research Centre, Hamilton, Ontario, L8V 1C3.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00055 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Disorders of Thrombosis and Hemostasis: Clinical and Laboratory PracticeFirst edition. Rodger L. Bick. 352 pages. Chicago: American Society of Clinical Pathologists Press; 1992. $68.00.Disorders of thrombosis and hemostasis are encountered by clinicians in various medical and surgical specialties. The complex hemostatic pathways and the bewildering array of available diagnostic tests underscore the need for a textbook that provides the uninitiated with the principles necessary for rapid diagnosis and treatment. Although two major texts cover the basic and clinical aspects of hemostasis in a definitive fashion, these multiauthor works are aimed at the experts. In contrast, this text will appeal to ... Author, Article, and Disclosure InformationAffiliations: McMaster University and Hamilton Civic Hospitals Research Centre, Hamilton, Ontario, L8V 1C3. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 240KeywordsAspirinClinical laboratoriesDisseminated intravascular coagulationHematology and oncologyHemostasisHemostaticsHeparinResearch laboratoriesThrombinThrombosis Issue Published: 1 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PULMONARY HYPERTENSION IN PATIENTS WITH LEFT HEART DISEASE: COMPARISON BETWEEN TRANSPULMONARY PRESSURE GRADIENT AND DIASTOLIC PULMONARY VASCULAR PRESSURE GRADIENT
Authors: Tatsuro Ibe, Hiroshi Wada, Kenichi Sakakura, Nahoko Ikeda, Yoshitaka Sugawara, Takeshi Mitsuhashi, Junya Ako, Shin-ichi Momomura
Journal: Journal of the American College of Cardiology (2014)
Treatment of molecular relapse in patients with acute myeloid leukemia using clofarabine monotherapy
Authors: Zdenek Racil, Martina Toskova, Dana Dvorakova, Ivana Jeziskova, Filip Razga, Lucie Buresova, Shira Timilsina, Jiri Mayer
Journal: American Journal of Hematology (2011)

Few studies have examined the treatment of molecular relapse in patients with acute myeloid leukemia (AML) using different treatment regimens. We describe for the first time in the literature experiences with administration of clofarabine monotherapy in the treatment of eight patients with AML with molecular relapse of the disease.
Emission control devices, fuel additive, and fuel composition changes.
Authors: W T Piver
Journal: Environmental Health Perspectives (1977)

Emission control devices are installed to meet the exhaust standards of the Clean Air Act for carbon monoxide and hydrocarbons, and it is necessary to know, from a public health point of view, how exhaust emissions may be affected by changes in fuel additives and fuel composition. Since these topics are concerned with developing technologies, the available literature on exhaust emission characteristics and the limited information on health effects, is reviewed.
Rhinitis symptoms and IgE sensitization as risk factors for development of later allergic rhinitis in adults
Authors: U. Bodtger, L. K. Poulsen, A. Linneberg
Journal: Allergy (2006)

Background: Rhinitis symptoms and IgE‐sensitization often mismatch. Asymptomatic sensitization is an established risk factor for later rhinitis, whereas it is not clear whether rhinitis is a risk factor for later development of IgE‐sensitization. Objective: To investigate whether nonallergic rhinitis is a risk factor for later development of IgE‐sensitization in adults during an 8‐year follow‐up period, and whether asymptomatic sensitization is a risk factor for later development of rhinitis. Methods: In a population‐based study of 15–69 years olds in 1990, 734 subjects were re‐examined in 1998. On both occasions questionnaires on rhinitis symptoms were completed and serum IgE (against birch, grass, mugwort, cat, dog, and Dermatophagoides pteronyssinus ) were determined (positive if ≥0.35 kU A /l). Asymptomatic sensitization: positive IgE levels without any rhinitis symptoms. Nonallergic rhinitis: rhinitis symptoms and no sensitization. Results: Asymptomatic sensitization to pollens, pets, or house dust mite was significantly associated with onset of rhinitis symptoms, also when changing baseline cut‐off for sensitization to ≥0.1 or ≥0.7 kU A /l. The 8‐year incidence of pollen‐related rhinitis was 15.1% and 2.6% in subjects sensitized and nonsensitized to pollens, respectively (odds ratio 6.1, 95% CI 2.3–16.0). Persistent or intermittent nonallergic rhinitis was not significantly associated with later sensitization, yet a positive trend for development was observed in nonallergic pollen‐related rhinitis. Conclusion: Asymptomatic sensitization but not nonallergic rhinitis was a significant risk factor for later development of allergic rhinitis.
A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
Authors: Philippe Ravassard, Yasmine Hazhouz, Séverine Pechberty, Emilie Bricout-Neveu, Mathieu Armanet, Paul Czernichow, Raphael Scharfmann
Journal: Journal of Clinical Investigation (2011)

Despite intense efforts over the past 30 years, human pancreatic β cell lines have not been available. Here, we describe a robust technology for producing a functional human β cell line using targeted oncogenesis in human fetal tissue. Human fetal pancreatic buds were transduced with a lentiviral vector that expressed SV40LT under the control of the insulin promoter. The transduced buds were then grafted into SCID mice so that they could develop into mature pancreatic tissue. Upon differentiation, the newly formed SV40LT-expressing β cells proliferated and formed insulinomas. The resulting β cells were then transduced with human telomerase reverse transcriptase (hTERT), grafted into other SCID mice, and finally expanded in vitro to generate cell lines. One of these cell lines, EndoC-βH1, expressed many β cell-specific markers without any substantial expression of markers of other pancreatic cell types. The cells secreted insulin when stimulated by glucose or other insulin secretagogues, and cell transplantation reversed chemically induced diabetes in mice. These cells represent a unique tool for large-scale drug discovery and provide a preclinical model for cell replacement therapy in diabetes. This technology could be generalized to generate other human cell lines when the cell type-specific promoter is available.
Antipyrine, paracetamol, and lignocaine elimination in chronic liver disease.
Authors: J A Forrest, N D Finlayson, K K Adjepon-Yamoah, L F Prescott
Journal: BMJ (1977)

The plasma half lives of antipyrine, paracetamol, and lignocaine given by mouth were measured in 23 patients with stable chronic liver diseases of varying severity. Fifteen patients received all three drugs and 19 at least two. The half life of paracetamol was abnormally prolonged in nine out of 17 patients (mean 2-9 hours, normal 2-0 hours), of antipyrine in 10 out of 19 patients (mean 30-4 hours, normal 12-0 hours), and of lignocaine in 19 out of 21 patients (mean 6-6 hours, normal 1-4 hours). Prolongation of the half lives of all three drugs was significantly correlated with an increase of the vitamin-K1-corrected prothrombin time ratio and a reduction in serum albumin concentration. There was no correlation with serum bilirubin concentration or serum alanine aminotransferase activity. This suggests that impaired drug elimination was related to depressed hepatic protein synthesis. Considerable prolongation of the half life of one drug was invariably associated with delayed elimination of the others. The half life of lignocaine, however, was always the most prolonged and was a highly sensitive indicator of hepatic dysfunction. The pharmacokinetic characteristics of a drug as well as the severity of liver disease should be taken into account when considering drug dosage in patients with chronic liver disease.
Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia.
Authors: H Ginsberg, G Kimmerling, J M Olefsky, G M Reaven
Journal: Journal of Clinical Investigation (1975)

We have used a continuous intravenous infusion of glucose (6 mg/kg/min), insulin (80 mU/min), epinephrine (6 mug/min), and propranolol (0.08 mg/min) to directly assess insulin resistance in 14 untreated adult onset diabetics with a mean (plus or minus SE) fasting plasma glucose level of 217 plus or minus 17 mg/100 ml. During the infusion endogenous insulin secretion is inhibited and steady-state plasma glucose and insulin levels are achieved after 90 min. Since similar steady-state levels of plasma insulin are achieved in all subjects, the plasma glucose concentration observed during the steady-state period is a measure of an individual's insulin resistance. Under these conditions, the mean (plus or minus SE) steady-state plasma glucose level of the 14 diabetic patients was 350 plus or minus 16 mg/100 ml, while that of 12 normal subjects was 121 plus or minus 4 mg/100 ml. Additional studies were performed in which control subjects and patients with diabetes had their fasting plasma glucose levels acutely raised or lowered to comparable levels before receiving the basic infusion mixture of glucose, insulin, epinephrine, and propranolol. The results of these studies indicated that differences in initial plasma glucose levels could not account for the different glucose responses of the two groups to the basic infusion. Finally, the mean (plus or minus SE) steady-state plasma glucose level of 104 plus or minus 17 mg/100 ml observed during the same basic infusion in five patients with fasting hyperglycemia (mean plus or minus SE, 142 plus or minus 12 mg/100 ml) secondary to chronic pancreatitis suggested that neither chronic hyperglycemia nor hypoinsulinemia per se necessarily lead to insulin resistance. These results demonstrate that marked insulin resistance exists in adult onset diabetics with fasting hyperglycemia. Since previous studies have documented the presence of insulin resistance in patients with chemical diabetes, the possibility exists that insulin resistance may be characteristic of adult onset diabetes mellitus.
Winning Back the Sky: A Tactical Analysis of Terrorism
Authors: Norman Frankel
Journal: JAMA (1986)

David G. Hubbard, MD, is a psychiatrist who has interviewed hundreds of terrorists in the course of his research on skyjacking. In Winning Back the Sky , Hubbard, who pulls no punches, focuses on one type of terrorism—skyjacking—and examines the motivations of the individual terrorist. What personal and ideological factors make him resort to terrorism, especially skyjacking? What is the personality makeup of a typical skyjacker? What are some responses that the target government can make to deter future incidents? Hubbard also addresses the important role of the media in terrorism, especially that of the electronic media.  In an earlier work ( The Skyjacker: His Flights of Fancy , New York, Macmillan Publishing Co Inc, 1971), Hubbard examined 52 skyjackers, isolating certain characteristics common to them. In Winning Back the Sky , he continues and updates this work, placing the personality of the skyjacker within the context of other motivating forces, such as the
Complications of Cystic Fibrosis
Authors: Harry Shwachman, Douglas S. Holsclaw
Journal: New England Journal of Medicine (1969)

IT is abundantly clear that with the increased longevity of patients with cystic fibrosis (CF) a host of unforeseen as well as anticipated complications have appeared. Of the unexpected developments in this disease is the almost universal finding of sterility in the male owing to anatomic defects in the accessory male structures (i.e., the epididymides, seminal vesicles and vasa deferentia1). Indeed, the finding of aspermia in an adult male with no obvious explanation should alert the physician to consider cystic fibrosis in the differential diagnosis. The end result of this condition in the male is comparable to the action . . .
Alcoholic doctors can recover.
Authors: G Lloyd
Journal: BMJ (1990)

A survey of doctors with alcohol and drug dependence who joined a self help group was carried out to find out whether they had recovered and whether their lifestyles and careers had been affected. After the group had been meeting for eight years 100 doctors had attended for over six months, and they were sent a questionnaire. Sustained recovery from dependence was achieved by 76 doctors for an average of nearly five and a half years. Among 15 who had not recovered, seven had died of causes directly related to alcohol misuse. Nearly a fifth of those surveyed had been assessed by the medical committee of the General Medical Council, and nearly half had lost their job but were in satisfactory employment again at the follow up survey. Those who recovered had contributed nearly 500 years of service to health care since contacting the group.
Differences in the mechanisms of uptake and endocytosis of small and large chylomicron remnants by rat liver
Authors: E Windler
Journal: Hepatology (1996)

Initial binding and subsequent endocytosis of small and large chylomicron remnants by rat liver were compared. Small and large chylomicrons were obtained from mesenteric lymph of glucose- or fat-fed rats, respectively. The low-density lipoprotein (LDL) receptor was up- and down-regulated as shown by LDL receptor messenger RNA (mRNA). The rate of removal of small chylomicron remnants by isolated perfused rat livers followed closely the activity of the LDL receptor. When mRNA was undetectable, the uptake was as low as that of lymphatic small chylomicrons. In contrast, the uptake of large chylomicron remnants into perfused rat livers was unaffected by changes of the LDL-receptor activity, but significantly reduced after livers were flushed with heparin or heparinase. Large chylomicron remnants were cleared from plasma much faster than small chylomicron remnants, but were more slowly internalized into hepatocytes. Both, small and large chylomicron remnants entered the pathway of receptor-mediated endocytosis as shown by electron microscopy and analysis of isolated endosomes. Yet, large chylomicron remnants were taken up into the compartment of uncoupling of receptors and ligands and multivesicular bodies at a much slower rate. This was independent of the activity of the LDL receptor and the heparin-releasable binding site. From these findings it is concluded that large chylomicron remnants initially bind rapidly to surface components other than the LDL receptor, one of which may be hepatic lipase. Yet, the consecutive internalization is slow. In contrast, small chylomicron remnants are removed at a slower rate from plasma, binding predominantly to the LDL receptor, but are more readily taken up into endosomes.