tbuckley/cabot-search huggingface dataset:
Abstract 1492: Systems analysis of epithelial-mesenchymal transition and cell invasion identifies functional gene signatures predictive of survival in lung cancer.
Authors: Mark J. Schliekelman, Ayumu Taguchi, Jun Zhu, Xudong Dai, Qing Zhang, Alice Chin, Chee-Hong Wong, Hong Wang, Adi Gazdar, Ite Laird-Offringa, Muneesh Tewari, Jean Paul Thiery, Samir Hanash
Journal: Cancer Research (2013)

Abstract We have implemented a systems approach to identify molecular features associated with mesenchymal or epithelial phenotypes and cell behavior in 38 lung adenocarcinoma cell lines that encompassed common known genomic alterations that drive the development of lung adenocarcinoma. Cell line characterization based on morphology, invasiveness, motility and cell-cell adhesion was integrated with proteomic, gene expression, microRNA and methylation profiles. Signatures were established from differential expression of transcripts and proteins in subsets of cell lines with mesenchymal and epithelial characteristics as well as high or low invasion and motility. The mesenchymal, invasion and migration signatures had common upregulation of genes or proteins related to cytoskeletal and actin-binding proteins. Sets of 148 and 74 transcripts corresponding to proteins that were overexpressed in mesenchymal cell lines and high invasive cell lines, respectively, were highly predictive of survival in three independent lung adenocarcinoma datasets. Subsets of 39 and 21 transcripts corresponding to cytoskeletal and acting binding proteins in the mesenchymal and invasive signatures were found to also predict survival in the three independent lung adenocarcinoma datasets, pointing to an association between cytoskeletal and actin binding proteins, a mesenchymal phenotype and tumor progression in lung adenocarcinoma. Citation Format: Mark J. Schliekelman, Ayumu Taguchi, Jun Zhu, Xudong Dai, Qing Zhang, Alice Chin, Chee-Hong Wong, Hong Wang, Adi Gazdar, Ite Laird-Offringa, Muneesh Tewari, Jean Paul Thiery, Samir Hanash. Systems analysis of epithelial-mesenchymal transition and cell invasion identifies functional gene signatures predictive of survival in lung cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1492. doi:10.1158/1538-7445.AM2013-1492
Letter: Screening for Down's syndrome.
Authors: P G Goldschmidt, S Bordman
Journal: BMJ (1976)

developed chronic hepatitis.Their sera were checked by Dr Eddleston and were also e-antigen and e-antibody negative.As reported,' we have been using a test of in-vivo macrophage (Kupffer cell) function by means of the clearance of microaggregated iodinated human serum albumin.Our normal values expressed as half life are 141 +3 3 min, and these particular patients had values of 25, 40, and 40 min respectively.The last two patients have died.These results are in contrast to those of other patients with chronic hepatitis who have been studied and have been found to have normal Kupffer cell function.2Dr Galbraith and his colleagues have evidence that their patients had some cellular and humoral immunity.We have evidence that the patients at risk have impaired macrophage function.Indeed it has previously been postulated that one of the important functions of the Kupffer cell is to protect the hepatic parenchymal cells from viral infection.
Extracellular Superoxide Dismutase Protects Lung Development in Hyperoxia-exposed Newborn Mice
Authors: Mohamed N. Ahmed, Hagir B. Suliman, Rodney J. Folz, Eva Nozik-Grayck, Maria L. Golson, S. Nicholas Mason, Richard L. Auten
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

We tested the hypothesis that targeted transgenic overexpression of human extracellular superoxide dismutase (EC-SOD) would preserve alveolar development in hyperoxia-exposed newborn mice. We exposed newborn transgenic and wild-type mice to 95% oxygen (O2) or air x 7 days and measured bronchoalveolar lavage cell counts, and lung homogenate EC-SOD, oxidized and reduced glutathione, and myeloperoxidase. We found that total EC-SOD activity in transgenic newborn mice was approximately 2.5x the wild-type activity. Hyperoxia-exposed transgenic mice had less pulmonary neutrophil influx and oxidized glutathione than wild-type littermates at 7 days. We measured alveolar surface and volume density in animals exposed to 14 days more of air or 60% O2. Hyperoxia-exposed transgenic EC-SOD mice had significant preservation of alveolar surface and volume density compared with wild-type littermates. After 7 days 95% O2 + 14 days 60% O2, lung inflammation measured as myeloperoxidase activity was reduced to control levels in all treatment groups.
New Environmental Factor in Congenital Disease
Authors: Alexander D. Langmuir
Journal: New England Journal of Medicine (1971)

This issue contains an original communication (Herbst, Ulfelder and Poskanzer) of great scientific importance and serious social implications. The highly significant correlation between the appearance of adenocarcinoma of the vagina in teen-age girls and young women, a very rare disease, and the ingestion of diethylstilbestrol by their mothers during the first trimester of pregnancy points to a new mechanism in the pathogenesis of congenital neoplastic disease and adds a new dimension to the whole matter of what drugs are safe or unsafe to administer to pregnant women. The first indication of the existence of this effect was reported a year . . .
Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.
Authors: C Strange, L Halstead, M Baumann, S A Sahn
Journal: Thorax (1990)

A patient with Wegener9s granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates. The stenosis developed in the area of previously noted tracheal ulceration and responded satisfactorily to carbon dioxide laser therapy.
Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas
Authors: George A. Calin, Chang-gong Liu, Manuela Ferracin, Terry Hyslop, Riccardo Spizzo, Cinzia Sevignani, Muller Fabbri, Amelia Cimmino, Eun Joo Lee, Sylwia E. Wojcik, Masayoshi Shimizu, Esmerina Tili, Simona Rossi, Cristian Taccioli, Flavia Pichiorri, Xiuping Liu, Simona Zupo, Vlad Herlea, Laura Gramantieri, Giovanni Lanza, Hansjuerg Alder, Laura Rassenti, Stefano Volinia, Thomas D. Schmittgen, Thomas J. Kipps, Massimo Negrini, Carlo M. Croce
Journal: Cancer Cell (2007)
P492Association of oxidative stress and cardiovascular risk in hemodialysis patients: role of Ferritin
Authors: A Gouri, A Dekaken
Journal: Cardiovascular Research (2014)

Introduction: Cardiovascular diseases remain a major cause of mortality in hemodialysis ( HD). Oxidative stress may contribute to accelerated atherogenesis associated with hemodialysis. The objective of this study was to evaluate serum ferritin in chronic hemodialysis patients and search for clinical and biological characteristics association.

Materials and Methods : This is a retrospective study of 45 chronic hemodialysis patients , 25 women and 20 men. We compared two groups of patients: G1 serum ferritin > 325 ng / ml and G2 ferritin < 325 ng / ml on:

Clinical parameters: age, sex, initial nephropathy, during of dialysis.

Biological parameters: hemoglobin (Hb), nutritional and inflammatory status (CRP, serum albumin, total cholesterol ), serum calcium, phosphorus, Ca x P product.

Comorbidities: diabetes , hypertension, cerebrovascular accident (stroke), coronary artery disease.

Results and Discussion : The average age of patients was 51.26 ± 15.21 years with a mean during of dialysis 1603 ± 1207 months. The initial nephropathy was in 31% of cases chronic kidney disease associated with diabetes. Comparison of two groups G1 and G1 showed that advanced age, presence of cardiovascular disease (CVD), increased serum creatinine, fasting blood glucose, corrected calcium, phosphate ( P) and LDL cholesterol were associated with elevated serum ferritin levels. Our results concord to the literature data and confirms that ferritin reflects a relative increase in the availability of iron and decreased antioxidant activity of specific iron and represents a risk factor for cardiovascular damage in hemodialysis advanced.
A new era for child protection
Authors: F. Godlee
Journal: BMJ (2010)

Child protection is probably one of the most difficult walks of medical life. A quick look at the career of paediatrician David Southall would certainly suggest so. Removed from his academic post in 1997 after complaints about the ethics of his research into “Munchausen syndrome by proxy”, banned from child protection work in 2004 for alerting the police to his suspicions about the deaths of Sally Clark’s two sons, and struck off the medical register in 2007 for allegedly accusing a mother of killing her son, Southall’s high profile battle could alone explain why paediatricians shun child protection work and why courts struggle …
Positive Selection at Reproductive ADAM Genes with Potential Intercellular Binding Activity
Authors: Barb Glassey, Alberto Civetta
Journal: Molecular Biology and Evolution (2004)

Many genes with a role in reproduction, including those implicated in fertilization and spermatogenesis, have been shown to evolve at a faster rate relative to genes associated with other functions and tissues. These survey studies usually group a wide variety of genes with different characteristics and evolutionary histories as reproductive genes based on their site of expression or function. We have examined the molecular evolution of the ADAM (a disintegrin and metalloprotease) gene family, a structurally and functionally diverse group of genes expressed in reproductive and somatic tissue to test whether a variety of protein characteristics such as phylogenetic clusters, tissue of expression, and proteolytic and adhesive function can group fast evolving ADAM genes. We found that all genes were evolving under purifying selection (d(N)/d(S) < 1), although reproductive ADAMs, including those implicated in fertilization and spermatogenesis, evolved at the fastest rate. Genes with a role in binding to cell receptors in endogenous tissue appear to be evolving under purifying selection, regardless of the tissue of expression. In contrast, positive selection of codon sites in the disintegrin/cysteine-rich adhesion domains was detected exclusively in ADAMs 2 and 32, two genes expressed in the testis with a potential role in sperm-egg adhesion. Positive selection was detected in the transmembrane/cytosolic tail region of ADAM genes expressed in a variety of tissues.
Is Leptin Involved in the Signaling Cascade After Myocardial Ischemia and Reperfusion?
Authors: Gema Frühbeck, Javier Salvador
Journal: Circulation (2000)

To the Editor:We read with great interest the elegant study by Chandrasekar et al 1 about the upregulation of CCAAT/enhancer binding protein, interleukin-6, the interleukin-6 receptor, and the signal transducer gp130 during reperfusion after a brief period of myocardial ischemia.The rapid and sustained production of interleukin-6 and the concomitant expression of the interleukin-6 receptor and gp130 suggest that these factors may participate in a local inflammatory cascade after myocardial ischemia and reperfusion.We approach this finding from a complementary point of view and comment on the possible involvement of leptin in the signaling cascade of postischemic myocardium.The ob gene product, also known as leptin, was discovered because of its very specific biological action: the ability to regulate body weight and appetite. 2Interestingly, leptin has a structure similar to that of the family of helical cytokines, which includes interleukins.Many cytokines, which were originally isolated on the basis of particular biological actions, have subsequently been shown to be capable of stimulating a variety of biological responses in a wide spectrum of cell types.Thus, leptin shares with other cytokines an extreme functional pleiotropy, and it is involved in quite diverse physiological functions, such as reproduction, hematopoiesis, immunity, and angiogenesis. 2,3he functional leptin receptors (OB-R), which have a widespread distribution, including the myocardium, belong to the class I cytokine receptor family. 2 The extracellular and cytoplasmic regions of OB-R and gp130 possess conserved motifs and are closely related to each other.OB-R and gp130 seem to mediate overlapping but distinct cytoplasmic signals.4 Furthermore, recent reports have shown that OB-R stimulates transcription via interleukin-6 and hematopoietin receptor responsive elements.5 Inflammation and vascularization play an important role in tissue healing after injury.In this sense, the activation of the immune system by leptin, together with its angiogenic effect, may prove of extraordinary physiological relevance.Thus, leptin may participate in the development of an inflammatory reaction in the infarcted tissue and accelerate tissue repair.The involvement of leptin in the signaling cascade after myocardial infarction is feasible both from a molecular and functional point of view.Interestingly, a worse clinical outcome after acute myocardial infarction is observed in obese patients, in whom a state of leptin-resistance may exist.In our opinion, a study of the potential participation of leptin may provide valuable information concerning cooperation among the different signaling systems and further our understanding of cytokine induction, which operates in a cascade fashion.
PREGNANCY EXPERIENCE AND THE DEVELOPMENT OF BEHAVIOR DISORDER IN CHILDREN
Authors: BENJAMIN PASAMANICK, MARTHA E. ROGERS, ABRAHAM M. LILIENFELD
Journal: American Journal of Psychiatry (1956)

The prenatal and paranatal records of children with behavior disorders born in Baltimore after 1939 show significantly more complications of pregnancy and delivery, and prematurity than their matched controls. The non-mechanical abnormalities such as toxemia appear to be the important factors in this association rather than the mechanical factors of delivery. These associations are still present even when intellectual and environmental factors are controlled. Hyperactive, confused, and disorganized children have even more of these abnormalities in their background. A hypothesis of a continuum of reproductive casualty is formulated consisting of brain damage incurred during these periods leading to a gradient of injury extending from fetal and neonatal death through cerebral palsy, epilepsy, mental deficiency, and behavior disorder. The implications of this continuum are discussed with regard to further research in the etiology, diagnosis, management, and prevention of these neuropsychiatric disorders.
New-onset psoriasis following treatment with the interleukin-1 receptor antagonist anakinra
Authors: M.A. González-López, V.M. Martínez-Taboada, M.C. González-Vela, H. Fernández-Llaca, J.F. Val-Bernal
Journal: British Journal of Dermatology (2008)

Conflicts of interest: none declared. Sir, Anakinra is a recombinant human form of interleukin‐1 receptor antagonist (IL‐1Ra) that blocks interleukin‐1 (IL‐1) signalling. It is administered as a daily subcutaneous injection, and is used to treat patients with rheumatoid arthritis (RA). The drug is generally well tolerated and has a good safety profile.1 The most common adverse effects are injection site reactions.2 We report a patient with RA who developed psoriasis following anakinra therapy. Recently, other biologic anticytokine drugs, such as all of the tumour necrosis factor (TNF)‐α blocking agents (etanercept, infliximab, adalimumab), have been reported to cause or exacerbate psoriasis.3 However, to our knowledge, no psoriatic lesions have been reported in patients treated with anakinra. A 75‐year‐old woman developed in 1995 a symmetrical polyarthritis involving shoulders, small joints of hands and feet, and knees. The rheumatoid factor was negative. She fulfilled the diagnostic criteria for RA.4 There was no personal or familial history of psoriasis. She had been treated with multiple disease‐modifying antirheumatic drugs, that were discontinued because of side‐effects or lack of efficacy. Despite treatment, her RA was still active and she developed typical erosions in metacarpophalangeal joints. Therefore, she was started on combined therapy with TNF‐α antagonists and methotrexate. Etanercept and infliximab were discontinued because of lack of efficacy, and adalimumab was withdrawn because of an episode of left cardiac failure. In March 2006, anakinra (100 mg daily subcutaneously) was started. In December 2006, 9 months later, she presented with typical psoriatic, scaly, erythematous plaques on the elbows (Fig. 1a). Skin biopsy from the patient's left elbow showed psoriasiform hyperplasia, parakeratosis and a lymphocytic infiltrate in the upper dermis, consistent with psoriasis (Fig. 1b). Treatment with anakinra was discontinued, and the psoriatic lesions improved significantly with the addition of topical steroids and vitamin D.
Released from the Contagious Hospital
Authors: George N. Braman
Journal: Annals of Internal Medicine (2001)

Ad Libitum3 July 2001Released from the Contagious HospitalGeorge N. Braman, MDGeorge N. Braman, MDBronx, NY 10471 (Braman)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-1-200107030-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “By the road to the contagious hospitalunder the surge of the bluemottled clouds driven from thenortheast—a cold wind …” William Carlos Williams“Spring and All” ... Author, Article, and Disclosure InformationAffiliations: Bronx, NY 10471 (Braman)Corresponding Author: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 July 2001Volume 135, Issue 1Page: 61KeywordsFeversPediatric infectionsRivers ePublished: 3 July 2001 Issue Published: 3 July 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prostate Cancer: Screening, Diagnosis, and Management
Authors: Marc B. Garnick
Journal: Annals of Internal Medicine (1993)

Objective: To provide physicians with a review of diagnosis, screening, staging evaluation, treatment options, prognosis, psychosocial issues, economic considerations, and future research directions in the management of patients with all stages of prostate cancer. Data Sources: A MEDLINE search of articles relating to the diagnosis, staging, screening, surgery, radiation therapy, medical management, and research in prostate cancer. Emphasis on information reported from government- and nongovernment-sponsored large cooperative trials, consensus development conferences, and proceedings of prostate cancer organ site workshops. Study Selection: Results of randomized treatment trials and consensus summary statements are reported where long-term results (> 5 years follow-up) are available for localized prostate cancer treatment and where survival outcomes are available for metastatic disease treatment. Data Synthesis: Both qualitative and quantitative data are reported. Information on staging, management, and prognosis of localized prostate cancer is based on studies that are predominantly nonrandomized, include heterogeneous patient groups, and often use differing outcome measures. Information on management of metastatic prostate cancer is more quantitative and includes side effects of treatment and survival results obtained from randomized, prospective, multi-institutional studies. Conclusions: Despite the increase in prostate cancer incidence and detection, substantial controversy still exists about the advisability and effectiveness of screening programs, the most appropriate staging evaluation, and the optimal management of patients with all stages of prostate cancer. Although randomized, prospective studies attempt to address some of these issues, physicians must appreciate inherent ambiguities involved in recommending staging and treatment choices.
Frequency and Clinical Pattern of Vitelliform Macular Dystrophy Caused by Mutations of Interphotoreceptor Matrix IMPG1 and IMPG2 Genes
Authors: Isabelle Meunier, Gaël Manes, Béatrice Bocquet, Virginie Marquette, Corinne Baudoin, Bernard Puech, Sabine Defoort-Dhellemmes, Isabelle Audo, Robert Verdet, Carl Arndt, Xavier Zanlonghi, Guylène Le Meur, Claire-Marie Dhaenens, Christian P. Hamel
Journal: Ophthalmology (2014)
Urinary Excretion of Total Proteins, Albumin, and β2-Microglobulin During Rest and Exercise in Diabetic Adolescents With and Without Retinopathy
Authors: Jacques Poortmans, Harry Dorchy, Daniel Toussaint
Journal: Diabetes Care (1982)

To determine whether protein excretion during exercise is an earlier sign of renal dysfunction in diabetic adolescents than the basal measurements, urinary creatinine, total proteins, albumin, and beta 2-microglobulin were studied before, immediately after, and 30 min after exercise until exhaustion on a bicycle ergometer in a group of 21 adolescent diabetic boys (Albustix negative) and in a comparable control group. Among the 21 diabetic subjects, 11 had an incipient retinopathy diagnosed by fluorescein angiography. Urinary output of creatinine was similar in diabetic and in nondiabetic groups, and did not vary during exercise. At rest, the urinary output of total proteins, albumin, and beta 2-microglobulin was significantly higher in diabetic subjects than in controls. These data suggest that the subclinical proteinuria of diabetes is of mixed origin, being both glomerular and tubular. An exercise test leading to exhaustion did not give any additional information other than the basal excretion. There was no difference between diabetic subjects with early retinal vascular changes and those free from all retinopathy.
Slicing the Pie: Correlating HbA1c values with average blood glucose values in a pie chart form
Authors: Karl W Brewer, H Peter Chase, Susie Owen, Satish K Garg
Journal: Diabetes Care (1998)

OBJECTIVE The purpose of this study was to define the correlation between HbA1c values and the percentage of home blood glucose (HBG) measurements within given ranges in a pie chart in three age-groups of subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS HbA1c values were compared with HBG measurements in subjects who did at least three blood glucose tests per day over 30 days in three age-groups: 5–11, 12–16, and 17–35 years. The blood glucose values were arbitrarily divided into three groups, defined as the percentage of HBG measurements within, above, and below target range. Each range was then compared with the corresponding HbA1c value. Longitudinal data were also collected for 279 of the subjects after a mean of 139 days. RESULTS A strong correlation (P = 0.001) was found between HbA1c values and the average blood glucose, and also with the percentage of HBG measurements within, above, and below target range in each of the three age-groups (P &amp;lt; 0.001). Analyses of longitudinal data showed a strong correlation of the changes in HbA1c values to the changes in blood glucose values. CONCLUSIONS These data showed that a pie-shaped graph of the HBG data can be useful as a clinical parameter in helping patients and families attain desired HbA1c values.