tbuckley/cabot-search huggingface dataset:
Interferon-α Treatment and Formation of Factor VIII Antibodies
Authors: Mike Makris
Journal: Annals of Internal Medicine (1997)

Letters15 May 1997Interferon-α Treatment and Formation of Factor VIII AntibodiesMike Makris, MA, MD and F. Eric Preston, MDMike Makris, MA, MDRoyal Hallamshire Hospital, Sheffield, S10 1SG, United KingdomSearch for more papers by this author and F. Eric Preston, MDRoyal Hallamshire Hospital, Sheffield, S10 1SG, United KingdomSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their small controlled study, Mauser-Bunschoten and colleagues [1] found the same incidence of antibodies to factor VIII (inhibitors) in hemophiliacs treated with interferon-α as in the untreated control group. The authors concluded that interferon-α does not increase the risk for development of factor VIII inhibitors. The incidence of new inhibitors in the control group, however, is 92 cases per 1000 patient-years; this rate is more than 20 times greater than that previously reported in the Netherlands (4.4 per 1000 patients-years) [2]. Furthermore, at approximately the same time during which their interferon-α trial was being conducted, an ...References1. Mauser-Bunschoten EP, Damen M, Reesink HW, Roosendaal G, Chamuleau RA, van den Berg HM. Formation of antibodies to factor VIII in patients with hemophilia A who are treated with interferon for chronic hepatitis C. Ann Intern Med. 1996; 125:297-9. Google Scholar2. Rosendaal FR, Nieuenhuis HK, van den Berg HM, Heijboer H, Mauser-Bunschoten EP, van der Meer J, et al. A sudden increase in factor VIII inhibitor development in multitransfused haemophilia A patients in The Netherlands. Blood. 1993; 81:2180-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: Royal Hallamshire Hospital, Sheffield, S10 1SG, United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByACQUIRED HEMOPHILIATreatment of chronic hepatitis C in haemophilia patientsHEPATITIS IN HAEMOPHILIA 15 May 1997Volume 126, Issue 10Page: 829KeywordsAntibodiesBiopsyChronic hepatitisHIVHemophilia AHepatitis AHepatitis C virusInterferonsLiver Issue Published: 15 May 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Delivery of DNA and siRNA by novel gemini-like amphiphilic peptides
Authors: Mark Damen, Jamil Aarbiou, Stijn F.M. van Dongen, Ruvalic M. Buijs-Offerman, Patricia P. Spijkers, Maaike van den Heuvel, Kristina Kvashnina, Roeland J.M. Nolte, Bob J. Scholte, Martin C. Feiters
Journal: Journal of Controlled Release (2010)
A STUDY OF EXTERNAL PANCREATIC SECRETION IN MAN
Authors: Benjamin Kogut, Milton J. Matzner, Albert E. Sobel
Journal: Journal of Clinical Investigation (1936)

An opportunity to study pure pancreatic secre- tion in man is extremely rare.Wohlgemuth (1) reported his observations in a young man with an external pancreatic fistula.He found that the rate of secretion varied considerably with the diet, that no flow was observed with a high fat diet, that there was an increased rate of secretion with Quantitative studies of the composition of the pancreatic fluid While at the hospital, specimens were obtained daily from the pancreatic fistula.About 15 cc.were obtained during an interval of about 12 hours.The patient was fed various diets as indicated in Table I.TABLE I Quantitative analysis of pancreatic secretion Non-Cl l~eat-Ur'ic pro-Total Total Cho- Cal Ph Po-|o Phos- CO C1 eat-Uric Urea tein nitro-pro-les-Sugar Cal-Phostas-Total pha-pH inine acid nitrogen tein * terol cium phorus sium base tase
Treatment Compliance and Early Termination of Therapy: A Comparative Study
Authors: Helen Lazaratou, Dimitris C. Anagnostopoulos, Maria Vlassopoulos, Chara Tzavara, George Zelios
Journal: Psychotherapy and Psychosomatics (2006)

&lt;i&gt;Background:&lt;/i&gt; Compliance in therapy appears to be linked to the process of therapeutic alliance. A positive patient–therapist relationship usually leads to successful completion of therapy. The aim of this study was to compare evidence, collected at two time periods in a Community Mental Health Center in Athens, on factors affecting treatment compliance. The hypothesis was that by modifying the therapeutic team’s functioning, noncompliance could be reduced. &lt;i&gt;Methods:&lt;/i&gt; Epidemiological data were collected from child and adolescent out-patient files at two time periods: time period A, 1990–1994, n = 455 (sample A) and time period B, 2000–2002, n = 476 (sample B). Variables pertaining to the patient, his family and recommended treatment were examined. Student’s t test and the Pearson χ&lt;sup&gt;2&lt;/sup&gt; test were used in order to explore the correlation of the variables with treatment completion in each sample. Logistic regression analyses were used to determine whether the effect of each variable on treatment completion differed between the two samples. &lt;i&gt;Results:&lt;/i&gt; In sample A, most patients (58.6%) did not comply with therapy. The type of recommended treatment, the number of sessions, season of admission and the type of presented problem were found to correlate with treatment completion. Between the two time periods, certain modifications were implemented in the team’s functioning (less diagnostic sessions, focused psychotherapy techniques, less time interval between referral and first diagnostic appointment). A significant reduction in the early termination rate (45.7%) was noted in sample B. The type of recommended treatment, the number of sessions, the family’s situation, the mother’s educational level and the patient’s gender were related to treatment completion in sample B. The effect of the type of proposed treatment and the mean number of sessions of the completed treatments differed significantly between the two samples. &lt;i&gt;Conclusions:&lt;/i&gt;Early termination rates in therapy decreased between two time periods. This decrease may be attributed to modifications in the team’s functioning, aimed at improving the therapeutic relationship. The limitation of this study is that only those factors pertaining to the service’s organization and functioning were investigated.
The Hepatorenal Syndrome Associated with Metastatic Angiosarcoma of the Gallbladder
Authors: STEVEN J. ROSANSKY
Journal: Annals of Internal Medicine (1982)

Brief Reports1 February 1982The Hepatorenal Syndrome Associated with Metastatic Angiosarcoma of the GallbladderSTEVEN J. ROSANSKY, M.D., CHARLES C. MULLENS, M.D.STEVEN J. ROSANSKY, M.D.Search for more papers by this author, CHARLES C. MULLENS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-2-191 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Hepatorenal Syndrome is defined as unexplained renal failure occurring in a patient with cirrhosis of the liver; it rarely occurs without cirrhosis. This syndrome has been reported with hemihepatectomy (1) and neoplastic disease of the liver (2). Metastatic malignancy-associated hepatorenal syndrome in patients with otherwise normal liver parenchyma has been reported previously in only three patients (2). We describe a patient who developed the hepatorenal syndrome associated with an angiosarcoma of the gallbladder that metastasized to the liver.A 59-year-old man was admitted with a 4-week history of right upper quadrant pain, nausea, and vomiting. The patient denied alcohol...References1. EPSTEINOSTERDE VELASCO MJR. Hepatorenal syndrome following hemihepatectomy. Clin Nephrol. 1976;5:129-33. MedlineGoogle Scholar2. VESINROBERTIVIGUIE PAR. Defaillance renale fonctionelle terminale chez des malades atteints de cancer du foie, primitif ou secondaire. Sem Hop Paris. 1965;41:1216-20. MedlineGoogle Scholar3. LEVINSKYALEXANDERVENKATACHALAM NEM. Acute renal failure. In: BRENNER BM, RECTOR FC JR, eds. The Kidney. Philadelphia: W. B. Saunders Co.;1981:1219-22. Google Scholar4. BRADLEYBRADLEY SG. The effect of increased intra-abdominal pressure on renal function in man. J Clin Invest. 1947;26:1010-22. CrossrefMedlineGoogle Scholar5. KEWLIMBRICKVARMASHERLOCK MCRS. Renal blood flow in malignant disease of the liver. Gut. 1972;13:421-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEVEN J. ROSANSKY, M.D.; CHARLES C. MULLENS, M.D.Affiliations: Wm. Jennings Bryan Dorn Veterans' Hospital and the University of South Carolina School of Medicine Columbia, South Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatorenal syndrome in metastatic cancersMesenchymal Tumors of the GallbladderMesenchymal Tumors of the GallbladderHepatorenal syndromeAngiosarcoma in the LungHepatorenal syndrome complicating chronic lymphocytic leukemiaHepatorenal syndromeHepatorenal syndrome 1 February 1982Volume 96, Issue 2Page: 191-192KeywordsAlcoholsCirrhosisGallbladderHepatorenal syndromeLiverLiver diseasesNauseaRenal failureVomiting ePublished: 1 December 2008 Issue Published: 1 February 1982 PDF downloadLoading ...
License to Plunder or to Paint
Authors: George D. Lundberg
Journal: JAMA (1983)

In an earlier editorial entitled "Rationing Human Life,"<sup>1</sup>we pointed out that many factors complicate judgments about the dispersal of funds from the public wealth for individual patients given heroic treatment to maintain life. We quoted Martin Luther King when he said that quality of life was more important than quantity. We stated that no one had determined how much one human life was worth and how society might decide where such enormous outlays of funds would be spent. Furthermore, no one had decided how to go about seeking solutions to these questions. In this issue ofThe Journal, two articles illustrate these dilemmas and seem to demonstrate conflicting positions in programs in which the federal government is involved. The first discusses the substantial number of persons who self-administer psychoactive drugs intravenously, especially heroin, and in whom a chronic inexorable form of kidney disease develops— the so-called heroin-associated nephropathy.
IMMEDIATE PERINEORRHAPHY. TWO FORMS OF RUPTURE; THE SPECIAL TREATMENT OF EACH; CERTAIN DETAILS IMPORTANT TO SUCCESS.
Authors: E. C. DUDLEY
Journal: JAMA (1883)

[Read before the Obstetric Section of the American Medical Association, June, 1883. During the past few years I have examined such gynæcological cases as came under my observation for evidence of previous perineal rupture, and have specially observed, in those cases in which the immediate mediate suture had been applied, whether the union had been such as to give the patient a solid, normal, triangular perineal body, capable of fulfilling all its functions. These observations were undertaken not for the purpose of publication, but as the basis for an individual judgment, and this is my excuse for the absence of accurately recorded statistics, but the conclusions which have forced themselves upon me are so adverse to what had been anticipated, and seem so important, that I venture to place them before fore you, as follows: Upon ocular examination of the cutaneous side of the perineal triangle, this was, in the
Angulated views in cineangiography.
Authors: C Green, L P Elliott
Journal: Circulation (1981)

the D-SACT in human subjects.4Theoretically, this should give a pure SN wave, uncontaminated by atrial activity.Figure 9 of Reiffel's article, a 2: 1 sinoatrial block, is shown as an example.This poses the interesting and difficult problem of distinguishing between deflection due to the recording of the SN electrogram (the Heisenberg uncertainty principle is as true in medicine as it is in physical chemistry), and the slower waves resulting from repolarization which are frequently observed.Such manifestations seem to be present in D,, and high in the right atrium, as indicated by Dr. Reiffel's arrow.It is not certain that baseline drifts are caused by movement of the catheter.In fact, the use of such a low frequency (0.1 Hz) for the recording of the slow waves lends itself to an inherent instability of the baseline, and therefore a possible inconsistency in the recording of the SN electrogram.This makes pharmacologic tests difficult, and justifies routine comparison of the D-SACT with the indirect procedures with which the SN function is evaluated.
Acupuncture Versus Paroxetine for the Treatment of Premature Ejaculation: A Randomized, Placebo-Controlled Clinical Trial
Authors: Didem Sunay, Melih Sunay, Yasin Aydoğmuş, Şahin Bağbancı, Hüseyin Arslan, Ayhan Karabulut, Levent Emir
Journal: European Urology (2011)
Varicella Vaccine — Are Two Doses Better Than One?
Authors: Anne A. Gershon
Journal: New England Journal of Medicine (2002)

The live attenuated varicella vaccine was approved by the Food and Drug Administration in 1995 for routine use in healthy persons older than one year of age who are susceptible to varicella. Children are given one dose of vaccine; two doses one to two months apart are given to persons older than 13 years of age. Acceptance of the vaccine in young children has been excellent; currently, more than 75 percent of appropriate children are immunized in the United States. The goal of the Centers for Disease Control and Prevention of reaching more than 90 percent of children less than . . .
Trichinellosis in the United States
Authors: Harry Most
Journal: JAMA (1965)

There has been a striking reduction in prevalence, mortality, and severity of infection due to<i>Trichinella spiralis</i>in man and pigs during the past 25 years. The factors of importance are associated with legislation requiring heat treatment of garbage used in swine feeding, reduction in the per capita consumption of pork, the extensive use of low-temperature storage of pork, increased consumption of "ready-to-eat" pork products, and public awareness of proper methods of cooking pork. Nevertheless, sporadic cases and epidemics still occur and frequently are the result of carelessness in the home feeding, processing, and serving of one or more pigs raised for personal use. It is probable that the present adult infection rate in the United States is 4% or less compared to 15% or 20% 25 years ago.
Treatment of chronic urticaria with cetirizine dihydrochloride a non-sedating antihistamine
Authors: L. JUHLIN, C. ARENDT
Journal: British Journal of Dermatology (1988)

The efficacy of cetirizine dihydrochloride, a new H1-antagonist with minimal sedative or anticholinergic side effects was evaluated in 30 patients with chronic idiopathic urticaria. In the first part of the study, cetirizine 10 mg and placebo were compared in a double-blind cross-over trial. In the second part, patients who did not respond adequately in the first part were randomized, still double-blind, to receive 10 mg cetirizine either once daily or twice daily. In the first part, treatment was discontinued by 17 patients on placebo and two patients on cetirizine because of lack of efficacy. Cetirizine dihydrochloride was found significantly to reduce occurrence of weals, erythema and pruritus compared with placebo (P <0.001). Twenty-six of the patients improved on cetirizine and two on placebo. Mild sedation was noted by two patients on cetirizine and by one on placebo.
Exemestane prevented invasive breast cancer in postmenopausal women at moderately increased risk
Authors: Laura Rees Willett
Journal: Annals of Internal Medicine (2011)

Source Citation Goss PE, Ingle JN, Ales-Martinez JE, et al; NCIC CTG MAP.3 Study Investigators. Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med. 2011;364:2381-91. 21639806
Reviews, Notes, and Listings: Clinical Examination
Authors: Paul J. Rutala
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 April 1993Reviews, Notes, and Listings: Clinical ExaminationPaul J. Rutala, MDPaul J. Rutala, MDUniversity of Arizona College of Medicine, Tucson, AZ 85724.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical ExaminationOwen Epstein, G. David Perkin, David P. de Bono, and John Cookson. 414 pages. London: Gower Medical Publishing; 1992. $49.95.Two questions must be answered when comparing a new physical examination textbook to those currently available: 1) What does this book do differently? and 2) What does it do better? Because all texts present much the same basic subject matter, answering those questions largely involves style, organization, and presentation. Those factors influence greatly a decision regarding the utility of any offering to beginning clinical students.The first difference in this book is its focus on clinical aspects. Introductory chapters on medical ... Author, Article, and Disclosure InformationAffiliations: University of Arizona College of Medicine, Tucson, AZ 85724. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1993Volume 118, Issue 7Page: 576KeywordsArteriesClinical pathologyHeart rate ePublished: 15 August 2000 Issue Published: 1 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Infection of rabbits with human immunodeficiency virus 1. A small animal model for acquired immunodeficiency syndrome.
Authors: H Kulaga, T Folks, R Rutledge, M E Truckenmiller, E Gugel, T J Kindt
Journal: The Journal of Experimental Medicine (1989)

Injection of rabbits with a human T cell line infected with HIV-1 caused seroconversion within 6 wk, and HIV-1 could be isolated from PBL cultures of infected rabbits. Identity of the isolated virus with HIV-1 was shown by analysis of products amplified by the polymerase chain reaction. HIV-1 infection was seen in rabbits injected with HIV-1-infected cells alone as well as in those that were first infected with HTLV-1 and subsequently with HIV-1. There were no consistent signs of disease in the rabbits infected with HIV-1 alone but HTLV-1/HIV-1-infected rabbits showed signs of illness including diarrhea and weight loss, transient neurologic impairment and, in one animal, a rapidly progressing mammary adenocarcinoma. Examination of organs taken at necropsy from both HIV-1- and HTLV-1/HIV-1-infected animals showed splenic hyperplasia and lymphocyte infiltration of the lungs, as well as moderate damage to liver and kidney in some cases.
Kinetics and imaging of indium-11-labeled autologous platelets in experimental myocardial infarction.
Authors: K H Laws, J A Clanton, V A Starnes, F M Lupinetti, J C Collins, J A Oates, J W Hammon
Journal: Circulation (1983)

The kinetics of accumulation and the external imaging patterns of indium-111-labeled platelets infused in a dog model of left anterior descending coronary artery occlusion with reperfusion were studied. The effects of infarct age and regional residual myocardial blood flow upon platelet accumulation were quantified, and the capacity of indium-111 platelets to image the experimental infarction was evaluated qualitatively. The endocardial accumulation of indium-111 platelets occurred primarily in infarct zones with residual blood flow less than 0.6 times normal and was maximal (24.98 +/- 2.76 times normal) in the lowest blood flow zone (less than 0.1 times normal). Indium-111 platelet accumulation in the epicardium occurred in the regions with blood flow less than 0.6 times normal and was maximal (17.83 +/- 1.20 times normal) in the lowest blood flow zone (less than 0.1 times normal). The maximal endocardial and epicardial platelet accumulation occurred 24 hours after reperfusion and was significantly decreased at 48 hours. In vivo cardiac images revealed discrete areas of increased myocardial radioactivity uptake in the anterior wall of dogs 24 hours after reperfusion. All images 48 hours after reperfusion were negative. Thus, in the experimental setting, indium-111 platelets allow quantification of platelet accumulation after myocardial infarction at a tissue level and provide a noninvasive means of in vivo imaging of reperfused infarcted myocardium.
P60Different profile of serum miRNA in patients with patent vs. occluded target vessel in acute coronary syndrome
Authors: J Gacon, A Kablak-Ziembicka, E Stepien, T Przewlocki, F J Enguita, B Derlaga, P Podolec
Journal: Cardiovascular Research (2014)

Objective Circulating microRNAs (miRNAs) are recognized as useful cardiovascular biomarkers in acute coronary syndrome (ACS). Vessel occlusion is not always manifested with ST-elevation; no specific biomarkers have been identified to differentiate ACS with patent or occluded infarct-related coronary artery (IRA). Methods Forty-four consecutive patients (mean age 57.5±9.9 years) with uncomplicated ACS and positive test for myocardial necrosis were admitted. Patients were classified into 2 groups with respect to TIMI flow grading on occluded IRA (patent vs. occluded), and with respect to ST-elevation (STEMI vs. NSTEMI). Standard blood tests and inflammatory markers (hs-CRP, fibrinogen, TNF-α and IL-6) were assayed. Expression levels of selected serum miRNAs (miR-1, -16, -34a, -122, -124, -208b, 133a/b, -375, and -499) were analyzed. Results Sixteen patients were categorized to the patent and 28 to the occluded groups; consistently, 17 STEMI and 27 NSTEMI patients were classified. No demographic differences between STEMI vs. NSTEMI and patent vs. occluded patients were found. STEMI patients had significantly higher troponin T levels but no significant differences with regard to TNFa, hs-CRP were found. In the STEMI group lower fibrinogen concentrations (3.4±1.24 vs. 4.4±1.78 g/L; p=0.049) and a trend to difference in IL-6 levels (9.2±6.62 vs. 5.7±5.43 pg/mL; p=0.073) were observed. Additionally, miR-134 expression was 3.83 fold higher in STEMI vs NSTEMI (p < 0.05).Patients with the occluded IRA had significantly higher levels of circulating miR-133a (fold change: 7.00), miR-133b (4.57), miR-34a (5.50), miR-124 (2.55) and miR-134 (3.45). Conclusions The degree of target vessel occlusion determines circulating miRNA expression. Patent artery produces less circulating brain and cardiac related miRs. It demonstrates distinct pathomechanism of cell damage during MI related ischemia.