A Cryo-precipitating Factor
Authors: ELI MANOR
Journal: Annals of Internal Medicine (1962)

Case Studies1 November 1962A Cryo-precipitating FactorELI MANOR, M.D.ELI MANOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-5-810 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1933 Wintrobe and Buell (1) described a cold precipitable globulin in the serum of a patient with multiple myeloma. The term cryoglobulin was introduced by Lerner and Watson (2) to describe proteins with this abnormal physical characteristic. Korst and Kratochvil (3) reported a protein that clotted and had many other physical and chemical properties similar to those of fibrinogen. It also exhibited the property of reversible precipitation on chilling, and the designation cryofibrinogen was suggested. These proteins have been noted in many disease entities, and recent reports (4-10) have adequately reviewed the literature. 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Author, Article, and Disclosure InformationAuthors: ELI MANOR, M.D.Affiliations: Tel-Aviv,From the Department of Internal Medicine "A," Asaf-Harofe Government Hospital, Israel.Requests for reprints should be addressed to Eli Manor, M.D., Rothschild Municipal Hospital, Golomb Street, Haifa, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCryoglobulinemia associated with a macroglobulin 1 November 1962Volume 57, Issue 5Page: 810-819KeywordsAnemiaBlood plasmaFibrinogenGlobulinsHospital medicineMultiple myelomaPlasma proteinsProteins ePublished: 1 December 2008 Issue Published: 1 November 1962 PDF downloadLoading ...