tbuckley/cabot-search huggingface dataset:
Epitope analysis of HLA‐DR‐restricted helper T‐cell responses to <i>Der p</i> II, a major allergen molecule of <i>Dermatophagoides pteronyssinus</i>
Authors: M. Okano, T. Nagano, M. Nakada, Y. Masuda, K. Kino, H. Yasueda, Y. Nose, Y. Nishimura, N. Ohta
Journal: Allergy (1996)

Okano M, Nagano T, Nakada M, Masuda Y, Kino K. Yasueda H, Nose Y, Nishimura Y, Ohta N. Epitope analysis of HLA‐DR‐restricted helper T‐cell responses to Der p II, a major allergen molecule of Dermatophagoides pteronyssinus . T‐cell epitopes of Der p II, a major allergen of Dermatophagoidees pteronpssinus , were analyzed by using human T‐cell clones. We tested 38 cloned T cells from two Japanese patients with allergic rhinitis, and identified at least two peptides (K33–T47 and 158–C73) as helper T‐cell epitopes. The former epitope was shown to be restricted by HLA‐DRBI* 1502, and the latter by HLA‐DRB1 *0405, both of which are typical Japanese HLA‐DR alleles, suggesting that those T‐cell epitopes might be important for the onset of house‐dust mite allergy in the Japanese population. We prepared 15 analog peptides of the HLA‐DRB1*1502‐restricted 15‐mer peptide. Of those 15 residues, five (F35, L37, A39, F41. and E42) were critical for the epitope activity, and three residues (F35, A39, and E42) seemed to be included in anchor motifs for HLA‐DRB1*1502. The epitope peptide was also recognized by HLA‐DRB1*1502‐positive healthy donors; however. only allergic T cells showed Th2 functions. Antigen‐presenting cells of nonallergic donors were able to activate allergic T cells to express Th2 function. This seemed to suggest that antigen recognition of T cells, as well as additional unknown factors which promote Th2, rather than Th1, responses, might be important for the onset of house‐dust mite allergy.
Efficacy and safety of ABT-874, a monoclonal anti–interleukin 12/23 antibody, for the treatment of chronic plaque psoriasis: 36-week observation/retreatment and 60-week open-label extension phases of a randomized phase II trial
Authors: Alexa B. Kimball, Kenneth B. Gordon, Richard G. Langley, Alan Menter, Renee J. Perdok, Joaquin Valdes
Journal: Journal of the American Academy of Dermatology (2010)
ANGIOGRAPHIC PATTERNS OF LATE RESTENOSIS AFTER SIROLIMUS-ELUTING STENT IMPLANTATION: SERIAL (8-MONTH AND 2-YEAR) ANGIOGRAPHIC FOLLOW-UP
Authors: Nehiro Kuriyama, Yoshio Kobayashi, Tatsuya Nakama, Daigo Mine, Mitsuhiro Shimomura, Kensaku Nishihira, Katsumasa Nomura, Keiichi Ashikaga, Akihiko Matsuyama, Yoshisato Shibata
Journal: Journal of the American College of Cardiology (2010)
Improved Radionuclide Imaging of the Pancreas
Authors: M. H. Nathan
Journal: JAMA (1978)

<h3>To the Editor.—</h3> With the advent of ultrasound and body computerized tomography (CT) scanning, radionuclide imaging of the pancreas is rapidly being replaced. However, there are still many hospitals where CT scanning or newer Grey-scale ultrasound is not available and where pancreatic radionuclide imaging is still being performed. Rodriguez-Antunez et al<sup>1</sup>were correct in 96% of 107 pancreatic scans interpreted as normal and had a 57% accuracy in those reported as abnormal. Sodee<sup>2</sup>had a diagnostic accuracy of 94% among 220 scans interpreted either as normal or abnormal. Most investigators agree that there is about a 92% accuracy when the pancreatic scan is reported normal but only about 51% accuracy when reported abnormal.<sup>3</sup> The radioactive imaging agent used in pancreatic scanning is selenomethionine Se 75, which is incorporated into the pancreatic enzymes. Unfortunately, in addition to radioactive labeling of the pancreas in this process, the liver also
Shirts and Skins
Authors: Joel Stein
Journal: Annals of Internal Medicine (2013)

On Being a Doctor2 April 2013Shirts and SkinsJoel Stein, MDJoel Stein, MDFrom Columbia University, New York, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-7-201304020-00011 Audio Reading - “Shirts and Skins” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Shirts and Skins," by J. Stein. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I walk into hospital rooms every day, but this time was different. My father was in this particular hospital room, trying to recover from total hip arthroplasty. As physicians, my father and I both knew that surgery is never risk-free, but neither of us anticipated this much postoperative drama. I took a deep breath before entering, hoping to find him in better spirits and without new complications.Our welcome hug was difficult with his various wires and tubes in the way. I had barely settled into the chair when he shared the day's epiphany with me. “I've divided the physicians ... Author, Article, and Disclosure InformationAffiliations: From Columbia University, New York, New York.Corresponding Author: Joel Stein, MD, Columbia University, 180 Fort Washington Avenue, Harkness Pavilion Room HP-1-165, New York, NY 10032; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Shirts and Skins” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Shirts and Skins," by J. Stein. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byToward a Renascence of Physical Diagnosis in the Intensive Care Unit 2 April 2013Volume 158, Issue 7Page: 564-565KeywordsCardiac electrophysiologyComputersEmotionsHeartHipNursesParoxysmal supraventricular tachycardiaSurgeryThoraxTotal hip arthroplasty ePublished: 2 April 2013 Issue Published: 2 April 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Severe Rhabdomyolysis Related to Cerivastatin without Gemfibrozil
Authors: David J. Hyman, Andrea Henry, Addison Taylor
Journal: Annals of Internal Medicine (2002)

Letters2 July 2002Severe Rhabdomyolysis Related to Cerivastatin without GemfibrozilDavid J. Hyman, MD, MPH, Andrea Henry, PharmD, and Addison Taylor, MDDavid J. Hyman, MD, MPHHarris County Hospital District; Houston, TX 77030 (Hyman, Henry, Taylor)Search for more papers by this author, Andrea Henry, PharmDHarris County Hospital District; Houston, TX 77030 (Hyman, Henry, Taylor)Search for more papers by this author, and Addison Taylor, MDHarris County Hospital District; Houston, TX 77030 (Hyman, Henry, Taylor)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-1-200207020-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The hydroxymethylglutaryl coenzyme A reductase inhibitors (“statins”) decrease serum cholesterol levels and morbidity and mortality from coronary heart disease. Although these drugs are well tolerated, serious adverse effects may occur. All members of this class may cause rhabdomyolysis, particularly when combined with gemfibrozil.We report six cases of severe rhabdomyolysis in patients taking cerivastatin without concomitant gemfibrozil. The patients were symptomatic (creatine kinase levels >5000 U/L) and were hospitalized with no other clear causes of rhabdomyolysis (Table). The cases occurred among approximately 3000 patients exposed to the drug for about 9 months. All six patients described here ... Author, Article, and Disclosure InformationAffiliations: Harris County Hospital District; Houston, TX 77030 (Hyman, Henry, Taylor) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeasures of Disease FrequencyCa2+-Releasing Effect of Cerivastatin on the Sarcoplasmic Reticulum of Mouse and Rat Skeletal Muscle Fibers 2 July 2002Volume 137, Issue 1Page: 74KeywordsCreatine kinaseDatabasesDrugsHealth careHospital medicineMorbidityMortalityPrevention, policy, and public healthRhabdomyolysisStatins ePublished: 2 July 2002 Issue Published: 2 July 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
TCT-701 Two Year Outcomes Following Unprotected Left Main Stenting with First- vs. New-Generation Drug-Eluting Stents: The FINE Registry
Authors: Gill Buchanan, Alaide Chieffo, Chiara Bernelli, Matteo Montorfano, Mauro Carlino, Azeem Latib, Filippo Figini, Irene Franzoni, Santo Ferrarello, Alfonso Ielasi, Francesco Sacco, Massimo Slavich, Alessandro Durante, Alfredo Castelli, Antonio Colombo
Journal: Journal of the American College of Cardiology (2012)
Biomarkers for assessing human female reproductive health, an interdisciplinary approach.
Authors: B L Lasley, J W Overstreet
Journal: Environmental Health Perspectives (1998)

Identification of environmental hazards to reproductive health and characterization of the adverse outcomes necessitate a multidisciplinary approach. Epidemiologic studies are required for the identification of adverse health effects in human populations and then to confirm that specific exposures are responsible. Clinical studies are required to develop assays for reproductive biomarkers and to validate these assays prior to their application in the field. Assays for field use must be formatted and streamlined for large-scale applications and, whenever possible, computer algorithms should be developed to interpret biomarker data. Appropriate animal models must be identified, biomarker assays validated for that model, and animal experiments conducted to identify the mode of action and target organ of a putative reproductive toxicant. Finally, in vitro studies at the level of the cell and cell organelle are essential for mechanisms for toxicity to be clearly identified and understood. In this article we describe the interdisciplinary approach that we have developed for study of the effects of environmental agents on female reproductive functions. This effort requires specific skills of toxicologists, epidemiologists, physicians, biochemists, and physiologists.
Role of Growth Arrest and DNA Damage–inducible α in Akt Phosphorylation and Ubiquitination after Mechanical Stress-induced Vascular Injury
Authors: Sumegha Mitra, Saad Sammani, Ting Wang, David L. Boone, Nuala J. Meyer, Steven M. Dudek, Liliana Moreno-Vinasco, Joe G. N. Garcia, Jeffrey R. Jacobson
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

The stress-induced growth arrest and DNA damage-inducible a (GADD45a) gene is up-regulated by mechanical stress with GADD45a knockout (GADD45a(-/-)) mice demonstrating both increased susceptibility to ventilator-induced lung injury (VILI) and reduced levels of the cell survival and vascular permeability signaling effector (Akt). However, the functional role of GADD45a in the pathogenesis of VILI is unknown.
A MONOCEPHALUS, TETRABRACHIUS, TETRAPUS.
Authors: J. J. GOODING
Journal: JAMA (1906)

The birth of this monster occurred in my practice, July 23, 1905. The mother, a native of Ohio, white, and about 40 years of age, has a large family. The labor was normal, although it was thought to be seven weeks premature. The fetus lived ten minutes. It weighed eight pounds. It was a double female with single head and thorax, four arms and four legs. The two abdomens were separate. The head was normal, with a small spina bifida at the neck.
EEG Monitoring During Cardiac Arrest and Resuscitation
Authors: Jonathan Moss
Journal: JAMA (1980)

DOCUMENTATION of human cerebral electrical activity at the time of cardiac arrest is rarely available. During a recent case of emergency carotid endarterectomy, a 27-s period of ventricular asystole occurred. Cerebral electrical activity was lost within 15 s of asystole and returned almost instantly on resuscitation. This case is presented because complete documentation of physiological measurements for the period before, during, and immediately after the patient's cardiac arrest was available. <h3>Report of a Case</h3> The patient was a 62-year-old woman with a history of syncopal episodes for several months. Two days before surgery, she sustained an apparent stroke resulting in right-arm paralysis. Angiography disclosed severe left internal carotid artery stenosis. Preoperative ECGs showed evidence of intermittent anterolateral subendocardial ischemia. Because of progressive neurological deterioration, an emergency carotid endarterectomy was performed. Following insertion of intravenous (IV), radial, and pulmonary artery catheters and application of EEG and ECG monitors (including precordial leads),
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
Authors: Bing Xia, Josephine C Dorsman, Najim Ameziane, Yne de Vries, Martin A Rooimans, Qing Sheng, Gerard Pals, Abdellatif Errami, Eliane Gluckman, Julian Llera, Weidong Wang, David M Livingston, Hans Joenje, Johan P de Winter
Journal: Nature Genetics (2006)
Priority setting in the NHS: reports from six districts.
Authors: C Ham
Journal: BMJ (1993)

District health authorities must make choices on the use of their funds and the priorities that should be pursued. In future they may be able to place greater weight on the views of local people and evidence on cost effectiveness of different services. This paper reviews developments in a recent study of six district health authorities with an interest in priority setting. On the whole they had avoided excluding services entirely from their contracts; they experienced difficulty in comparing different services, and made more progress by analysing priorities within individual service areas than by comparing quite different services. The absence of information to guide priority setting was a major problem. A major effort had been made to involve the public in decision making, and a range of tools and methods developed to support work on priority setting. The impact of the work done so far has varied; district health authorities are still at an early stage in developing their work on priority setting.
Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall.
Authors: M J Daemen, D M Lombardi, F T Bosman, S M Schwartz
Journal: Circulation Research (1991)

The present study was undertaken to explore the possibility that neointimal smooth muscle cells, the characteristic cells of restenosis and atherosclerosis, are selectively stimulated to replicate by a hypertensive stimulus. Angiotensin II (AII) was infused by osmotic minipumps for 2 weeks in 4.5-month-old rats. Group A received AII (200 ng/min) 2 weeks after a balloon catheter-induced injury of the thoracic aorta and left common carotid artery. Group B received only AII, group C only balloon denudation, and group D neither balloon injury nor AII. During the AII or Ringer's solution infusion, all animals received [3H]thymidine via a second minipump to measure DNA synthesis. AII increased the systolic pressure by more than 40 mm Hg. AII significantly increased DNA synthesis in the media of the carotid artery from 0.2 +/- 0.2% in group C to 2.5 +/- 1.5% in group A (mean +/- SD, n = 5 or 6). DNA synthesis in the neointima of the carotid artery significantly increased with AII from 4.8 +/- 4.2% in group C to 19.8 +/- 13.9% in group A. Cross-sectional area of the neointima almost doubled during AII infusion, and it increased approximately 25% in the media. Comparable results were obtained in the aorta. In a second experiment, AII was infused (125 ng/min) for 2 weeks in 11-week-old rats. Concomitantly, [3H]thymidine was given. Control rats received Ringer's solution and [3H]thymidine in their pumps. Blood pressures were elevated to the same extent as in the older animals.(ABSTRACT TRUNCATED AT 250 WORDS)
The Infant Gastroesophageal Reflux Questionnaire Revised: Development and Validation as an Evaluative Instrument
Authors: Leah Kleinman, Margaret Rothman, Richard Strauss, Susan R. Orenstein, Suzanne Nelson, Yvan Vandenplas, Salvatore Cucchiara, Dennis A. Revicki
Journal: Clinical Gastroenterology and Hepatology (2006)
Acute otitis media: clinical course among children who received a short course of high dose antibiotic.
Authors: J Bain, E Murphy, F Ross
Journal: BMJ (1985)

A prospective study was carried out in 274 children aged 3 to 10 years with acute otitis media. They were randomly allocated to one of two treatment regimens: (a) a seven day course of amoxycillin 125 mg three times a day, and (b) a two day course of amoxycillin 750 mg twice a day. They were followed up by symptom diaries and clinical examination. The findings in the 243 children who completed the trial showed that the short course of treatment was as effective as the seven day course in the speed of resolution of symptoms and signs, irrespective of previous history of otitis media or of episodes in which bulging of the eardrums was observed at presentation. A subgroup of 185 children was followed up for one year after entry to the trial. During this period no appreciable differences emerged between the two antibiotic regimens, either in recurrence rate of otitis media or in the frequency of hearing loss at one month and six months after entry to the study. Side effects of treatment were few, and those that could be attributed to antibiotic use occurred with equal frequency in the two treatment groups.
Biomedical models and healthcare systems
Authors: Peter Davies
Journal: BMJ (2005)

Editor—Like Wade and Halligan,1 I think that current medical thinking about illness has serious limitations, which leads to problems for doctors and patients and helps administrators with diagnosis and certification.2,3 The traditional medical model is based on a direct link between lesion and symptom. Medical teaching rightly emphasises the processes linking symptoms with lesions.

Four groups of patients are discernible on the basis of such ideas.

The first comprises those whose symptoms are due to disease. This is home territory for doctors and reasonably well dealt with by current medical knowledge.

The second includes patients who have disease but no symptoms. This is the territory covered by screening, and, although of debatable worth, medicine has developed strategies for making progress in this area such as the Wilson-Junger screening criteria.

The third group consists of people who have no symptoms and no disease. These people are healthy as far as medicine is concerned and will not often attend the doctor.

The fourth group consists of patients who have symptoms but no disease. This group causes most of the problems in medical practice. In some of these people we as doctors can classify the symptoms into syndromes such as schizophrenia, depression, irritable bowel syndrome, and so we feel as if we are “diagnosing” an “illness.” With some symptoms we struggle even to do this. We can feel that we are trying to “knit fog” as we attempt to build a coherent picture out of multiple inexplicable symptoms.

We forget that we are trying to catch the symptoms within a disease matrix, which may not be a valid concept when there is no lesion present. There is a solidity, and validity, to the concept of any disease with a recognisable lesion that is lacking when no lesion has been shown.
Representational limitations of the one-place predicate
Authors: Peter F. Dominey
Journal: Behavioral and Brain Sciences (2003)

In the context of Hurford's claim that "some feature of language structure maps onto a feature of primitive mental representations," I will argue that Hurford's focus on 1-place predicates as the basis of the "mental representations of situations in the world" is problematic, particularly with respect to spatiotemporal events. A solution is proposed.
Calcium carbonate in cholesterol gallstones: Polymorphism, distribution, and hypotheses about pathogenesis*1
Authors: Donald R. Taylor, Roger S. Crowther, John C. Cozart, Pamela Sharrock, Jinguang Wu, Roger D. Soloway
Journal: Hepatology (1995)

This study of sets of cholesterol gallstones collected consecutively from 222 patients in La Paz, Bolivia, and Mexico City, Mexico, has developed a reliable infrared (IR) spectroscopic method for the detection of calcium carbonate in cholesterol gallstones and provided the basis for simultaneous identification of each of its three polymorphs: calcite, vaterite, and aragonite. The peaks in the 854 to 876 cm-1 region demonstrated 98% sensitivity and specificity for carbonate detection. As little as 3% carbonate by weight could be detected using these peaks. The overall incidence of carbonate was 19% in these populations containing a high proportion of Amerinds. Infrared microspectroscopy of 10 to 50 microns particles, dissected from stones, allowed a ring-by-ring examination of 11 carbonate-containing stones. It was determined that different carbonate polymorphs, when present in the same gallstone, almost always occurred in separate rings. In approximately half of the gallstones, different polymorphs were present in successive layers in the same stone, indicating that conditions governing stone growth changed cyclically. Carbonates were usually precipitated in peripheral layers rather than in the center, supporting the theory that formation of calcium carbonates may be related to episodes of intermittent obstruction of the cystic duct, as opposed to being a major factor in stone nidation.
Role of Single Photon Emission Computed Tomography/Computed Tomography in Localization of Ectopic Parathyroid Adenoma
Authors: Kamran Akram, John Anthony Parker, Kevin Donohoe, Gerald Kolodny
Journal: Clinical Nuclear Medicine (2009)

The parathyroid glands are located posterior to the upper and lower poles of the thyroid and are derived from the third and fourth pharyngeal pouches. Usually there are only 2 superior glands, whereas only 40% of patients have their inferior glands located near the inferior thyroid poles. Ectopic locations include the carotid sheath, anterior mediastinum, retropharynx, or intrathyroidal locations. Single photon emission computed tomography/computed tomography (SPECT/CT) offers the advantage of combining function and anatomy for exact localization of ectopic parathyroid adenomas. In this pictorial review, we present 4 cases of hyperparathyroidism caused by ectopic parathyroid adenomas and review the literature on the additional value of their localization with SPECT/CT. Combined SPECT/CT scanners permit more reliable localization of ectopic adenomas. The additional information can aid in exact preoperative localization. In one study of 16 patients, SPECT/CT identified 39% more lesions compared with SPECT imaging alone. In other comparisons of planar, SPECT and SPECT/CT imaging modalities, SPECT/CT permitted the highest reader confidence in localization, especially for mediastinal adenomas. Larger studies are needed to establish the role and cost-effectiveness of SPECT/CT.