tbuckley/cabot-search huggingface dataset:
Gastrointestinal Cancers: Biology, Diagnosis, and Therapy
Authors: Norton J. Greenberger
Journal: JAMA (1996)

According to the latest cancer statistics<sup>1</sup>there will be 1 359 150 new cancer cases in the United States in 1996. Cancer involving the digestive organs will account for 222 500 new cases. Further, it is estimated that there will be 554 740 cancer deaths, and, of these, 125 410 will involve cancers of the digestive organs; colorectal cancer will rank second and pancreatic cancer will rank fifth. These data underscore the importance of gastrointestinal cancers. Thus, the textbook edited by Rustgi is a timely addition to other textbooks and monographs on the subject. The first section of<i>Gastrointestinal Cancers</i>provides a useful overview of the biology of gastrointestinal cancer, with appropriate emphasis on embryology, biochemistry, and molecular genetics. There follows a very useful discussion of the role of oncogenes (specifically peptide growth factors) and tumor-suppressor genes in normal and neoplastic cells. The bulk of the book consists of
Hepatotoxicity Complicating Flutamide Treatment of Hirsutism
Authors: Diane K. Wysowski
Journal: Annals of Internal Medicine (1993)

Letters1 December 1993Hepatotoxicity Complicating Flutamide Treatment of HirsutismDiane K. Wysowski, MD and Jean L. Fourcroy, MDDiane K. Wysowski, MDSearch for more papers by this author and Jean L. Fourcroy, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-11-199312010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In the United States, flutamide is approved by the Food and Drug Administration for use in combination with a luteinizing hormone-releasing hormone analog for the treatment of metastatic prostate cancer but not for benign prostatic hypertrophy, female hirsutism, or other hormonally mediated conditions.The development of serious hepatotoxicity in a 20-year-old woman who was given flutamide for hirsutism, who had no other known causes of liver disorder, and who recovered after withdrawal of the drug provides confirmatory evidence that this drug can cause serious hepatotoxicity. In our case series [1], we reported that two 58-year-old men treated with ...References1. Wysowski DK, Freiman JP, Tourtelot JB, Horton ML III. Fatal and nonfatal hepatotoxicity associated with flutamide. Ann Intern Med. 1993; 118:860-4. Google Scholar2. Cusan L, Dupont A, Belanger A, Tremblay RR, Manhes G, Labrie F. Treatment of hirsutism with the pure antiandrogen flutamide. J Am Acad Dermatol. 1990; 23:462-9. Google Scholar3. Gomez JL, Dupont A, Cusan L, Tremblay M, Suburu R, Lemay M, et al. Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients. Am J Med. 1992; 92:465-70. Google Scholar Author, Article, and Disclosure InformationAuthors: Diane K. Wysowski, MD; Jean L. Fourcroy, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPOLYCYSTIC OVARY SYNDROMETreatment of hyperandrogenism in women 1 December 1993Volume 119, Issue 11Page: 1150KeywordsBenign prostatic hyperplasiaCancer treatmentDrugsFood and Drug AdministrationLiverNauseaProstate cancerSigns and symptomsUrineVomiting ePublished: 15 August 2000 Issue Published: 1 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Creatine Kinase Levels in Women who Carry Genes for Three Types of Muscular Dystrophy
Authors: K. M. Wilson, K. A. Evans, C. O. Carter
Journal: BMJ (1965)

Beagle.He certainly was bitten by the vector of Chagas's disease, but there is no certainty that they were infected.The infection can cause myocardial damage and heart failure, megacolon and megaoesophagus, but it is often asymptomatic.Evidence from Darwin's writings and those of some of his relatives indicates that his symptoms were of palpitations, lassitude, headaches, tremulousness, sleeplessness, and flatulence brought on by meeting people and by emotionally charged situations.His exercise tolerance remained good until shortly before his death at the age of 73.Though attended by some of the best clinical observers of the day no signs of disease were detected.Persons may die with asymptomatic Chagas's disease, but it is considered to be beyond credibility that severe incapacity could have been produced by it for 40-50 years without the development of physical signs.There is evidence that several of Darwin's children who were not exposed to infection with Chagas's disease nevertheless had a disease similar to their father's.The course of the illness was unlike that of an organic disorder causing cardiac insufficiency in that the symptoms improved during the last decade of his life.The features of the illness strongly suggest a diagnosis of a functional disorder.Perhaps the most important piece of evidence is that the principal symptoms developed before Darwin sailed for South America.
Equity in health care Health needs vary among elderly people
Authors: E S Williams, C M Scott, C Godber
Journal: BMJ (1994)

service increment still seems to be linked to beds as the unit of currency for medical training.The links between London's health services, medical education, and research implied in the title of Sir Bernard Tomlinson's report' are not being systematically reshaped across the city.Secondly, the potential role of community health services trusts in providing an infrastructure based in the community to support learning and teaching is not well understood by the medical schools.Although talk of students being taught in the community is ubiquitous, this is understood primarily in terms of more teaching in general practice.This misses the additional and important opportunities within community health services trusts for students to leam about specialisms based in the community and innovations on the boundary between primary and secondary care-for example, hospital at home-and to experience many forms of multidisciplinary practice.The community health services trusts offer a range of services that provide opportunities for both teaching and research.We believe that medical educators need to become more knowledgeable about the potential in these trusts and to form new alliances if appropriate training is to be provided for doctors of the 21 st century.
Hepatitis C virus–like particles induce virus-specific humoral and cellular immune responses in mice
Authors: Martin Lechmann, Kazumoto Murata, Jujin Satoi, John Vergalla, Thomas F. Baumert, Jake T. Liang
Journal: Hepatology (2001)

We have recently described the production of hepatitis C virus-like particles (HCV-LPs) in insect cells that resemble the putative virions. Here we evaluate the humoral and cellular immunogenicity of the virus-like particles with or without viral p7 protein, a small viral polypeptide that resides between the structural and nonstructural regions of the HCV polyprotein and whose function has not been defined. Immunized BALB/c mice developed high titers of anti-E2 antibodies and virus-specific cellular immune responses including cytotoxic T lymphocytes and T helper responses with gamma interferon production. The virus-like particles without p7 generated a higher cellular immune response with a more T(H)1 profile than the particles with p7. Immunization of heat-denatured particles resulted in substantially lower humoral and cellular responses, suggesting that the immunogenicity is strongly dependent on particle formation. Administration of CpG oligonucleotide or cationic lipid 3beta-[N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol (DC-Chol), two potent adjuvants, did not significantly enhance the immunogenicity of HCV-LPs. Our results indicate that HCV-LPs can induce humoral and cellular immune responses and offer a promising approach to vaccine development.
Iron chelation therapy with deferasirox in patients with aplastic anemia: a subgroup analysis of 116 patients from the EPIC trial
Authors: Jong Wook Lee, Sung-Soo Yoon, Zhi Xiang Shen, Arnold Ganser, Hui-Chi Hsu, Dany Habr, Gabor Domokos, Bernard Roubert, John B. Porter
Journal: Blood (2010)
The Impaired Responsiveness of Chronic Lymphatic Leukemia (CLL) Lymphocytes to Allogenic Lymphocytes.
Authors: Martin J. Smith
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972The Impaired Responsiveness of Chronic Lymphatic Leukemia (CLL) Lymphocytes to Allogenic Lymphocytes.Martin J. Smith, M.D., Arne SlungaardMartin J. Smith, M.D.Search for more papers by this author, Arne SlungaardSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-871_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNormal lymphocytes respond to the presence of allogenic lymphocytes in cultures with a high uptake of3H-thymidine. We studied the interaction of chronic lymphatic leukemia (CLL) lymphocytes with normal allogenic lymphocytes, using the oneway, mixed leukocyte culture technique of Bach, with Ficoll-Hypaque gradient, to harvest lymphocytes. The lymphocytes of 11 patients with this disease were tested separately against those of 4 unrelated normal control persons. Contamination by nonmononuclear cells was uniformly less than 5%, and viability (eosin dye exclusion) was greater than 90%. In all 11 patients an impaired responsiveness was found. The mean response of CLL lymphocytes to those... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Martin J. Smith, M.D.; Arne SlungaardAffiliations: La Crosse, Wis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIMPAIRED IMMUNORESPONSIVENESS IN TUMOR PATIENTS 1 May 1972Volume 76, Issue 5Page: 871-871KeywordsCellsChronic lymphocytic leukemiaLymphocytesLymphocytic leukemia ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Cytogenetic Effects of Tranquilizing Drugs in Vivo and in Vitro
Authors: Maimon M. Cohen
Journal: JAMA (1969)

During a recent investigation of the effects of lysergic acid diethylamide (LSD) on human chromosomes, three individuals, included as controls, showed elevated frequencies of chromosomal breakage while being treated with chlorpromazine.<sup>1</sup>Subsequently, invitro observations on human leukocytes and fibroblasts suggested that diazepam is also capable of inducing chromosome damage.<sup>2</sup>Due to the widespread clinical use of such drugs in our population, an in-vivo and invitro cytogenetic study of several tranquilizing agents was carried out. <h3>Materials and Methods:</h3> <i>In Vitro Studies</i>.—Peripheral leukocyte cultures were initiated from two normal, healthy donors (one male and one female) with no known history of prior drug ingestion, radiation exposure, or recent viral infection. Chromosomes were obtained from cells of whole-blood inoculum (3 to 4 drops), grown in commercially available microculture kits, and incubated at 37 C for 72 hours. Two hours before harvest, colcemide was added at a final concentration of 0.05μg/ml
Exposure to Pets in Childhood and Risk of Atopic Disorders
Authors: Gary N. Greenberg, Sveta Mohanan, Sam G. Greenberg
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
George Edmund Hyson
Authors: Peter Savage
Journal: BMJ (2005)

the distinguished UK transplant immunologist and Nobel laureate.She spent her life supporting her husband's career and working hard for causes she cared about and believed in-the global environment, population control, and family planning.She was one of a redoubtable group of women who had to combat the most extraordinarily hostile attitudes in the early days of family planning.She was fond of quoting a letter published in the Lancet in 1930, when she was 17, saying that the subject "was something that no decent man would handle with a pair of tongs."In 1954, when she was 31, she met Margaret Pyke, chairwoman of the Family Planning Association, and this started her considerable contribution to the movement.She became a member of the executive in 1960, and was chairwoman from 1968 to 1970.For two decades, from 1957 to 1976, she was joint editor of Family Planning (now Family Planning Today).
Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia
Authors: Sanne Lugthart, Meyling H. Cheok, Monique L. den Boer, Wenjian Yang, Amy Holleman, Cheng Cheng, Ching-Hon Pui, Mary V. Relling, Gritta E. Janka-Schaub, Rob Pieters, William E. Evans
Journal: Cancer Cell (2005)
NSAIDs were associated with increased risk for mortality, regardless of time since first MI
Authors: Steven M. Belknap
Journal: Annals of Internal Medicine (2013)

Source Citation Olsen AM, Fosbøl EL, Lindhardsen J, et al. Long-term cardiovascular risk of nonsteroidal anti-inflammatory drug use according to time passed after first-time myocardial infarction: a nationwide cohort study. Circulation. 2012;126:1955-63. 22965337
Psychological distress in pregnancy and preterm delivery.
Authors: M Hedegaard, T B Henriksen, S Sabroe, N J Secher
Journal: BMJ (1993)

OBJECTIVE--To investigate if psychological distress during pregnancy is associated with increased risk of preterm delivery. DESIGN--Prospective, population based, follow up study with repeated measures of psychological distress (general health questionnaire), based on the use of questionnaires. SETTING--Antenatal care clinic and delivery ward, Aarhus University Hospital, Denmark. SUBJECTS--8719 women with singleton pregnancies attending antenatal care for the initial visit between 1 August 1989 and 30 September 1991; 5872 women (67%) completed all questionnaires. MAIN OUTCOME MEASURE--Preterm delivery. Estimation of gestational age at delivery was mainly based on early ultrasound measurements. RESULTS--In 197 cases (3.6%) the woman delivered prematurely (less than 259 days). A dose-response relation between psychological distress in the 30th week of pregnancy and risk of preterm delivery was found, but distress measured in the 16th week was not related to preterm delivery. Control of confounding was secured by the use of multivariate logistic regression models. Relative risk for preterm delivery was 1.22 (95% confidence interval 0.84 to 1.79) for moderate distress and 1.75 (1.20 to 2.54) for high distress in comparison to low distress. CONCLUSIONS--Psychological distress later in pregnancy is associated with an increased risk of preterm delivery. Future interventional studies should focus on ways of lowering psychological distress in late pregnancy.
Unprotected left main coronary artery stenting: immediate and medium- term outcomes of 140 elective procedures
Authors: Marc Silvestri, Paul Barragan, Joël Sainsous, Gilles Bayet, Jean-Baptiste Simeoni, Pierre-Olivier Roquebert, Gilles Macaluso, Jean-Louis Bouvier, Bertrand Comet
Journal: Journal of the American College of Cardiology (2000)
Too easily lead? Health effects of gasoline additives.
Authors: D B Menkes, J P Fawcett
Journal: Environmental Health Perspectives (1997)

Octane-enhancing constituents of gasoline pose a number of health hazards. This paper considers the relative risks of metallic (lead, manganese), aromatic (e.g., benzene), and oxygenated additives in both industrialized and developing countries. Technological advances, particularly in industrialized countries, have allowed the progressive removal of lead from gasoline and the increased control of exhaust emissions. The developing world, by contrast, has relatively lax environmental standards and faces serious public health problems from vehicle exhaust and the rapid increase in automobile use. Financial obstacles to the modernization of refineries and vehicle fleets compound this problem and the developing world continues to import large quantities of lead additives and other hazardous materials. Progress in decreasing environmental health problems depends both on the adoption of international public health standards as well as efforts to decrease dependence on the private automobile for urban transport.
Dutch government must meet cost of refugees' psychiatric care
Authors: Tony Sheldon
Journal: BMJ (2006)

The cost of long term psychiatric care for illegal residents in the Netherlands should be met by the state and not by a psychiatric hospital treating them, according to a legal test case.

A court in the Hague ruled that, although psychiatric hospitals had an obligation to provide such care, they did not receive adequate reimbursement for the treatment and therefore “suffered disproportionate damage.” A substantial number of the illegal (and therefore uninsured) patients were being treated under the law on compulsory admissions.

The Bavo RNO foundation, which provides psychiatric care in Rotterdam, brought the civil action against …
705 CONTRAST-ENHANCED ULTRASOUND FOR THE DIFFERENTIATION OF BENIGN AND MALIGNANT FOCAL LIVER LESIONS: A META-ANALYSIS AND SYSTEMATIC REVIEW
Authors: M. Friedrich-Rust, T. Klopffleisch, J. Nierhoff, E. Herrmann, M.D. Schneider, J. Vermehren, S. Zeuzem, J. Bojunga
Journal: Journal of Hepatology (2012)
Study gives reassurance on safety of xenotransplantation
Authors: J. Hopkins
Journal: BMJ (1999)

A large international study gives reassurance on the safety of xenotransplantation, the use of donor organs from non-human species, to alleviate the shortage of human organs (Science 1999;285:1236-41). Patients exposed to living pig tissue do not seem to have been infected with a pig virus.

Dr Khazal Paradis, director of clinical research at Imutran in Cambridge in the United Kingdom and lead author of the study, told the BMJ: “We hope to proceed to small, well …
Very Small<i>P</i>Values—Reply
Authors: Sarah M. Hartz, Laura J. Bierut, Michele T. Pato
Journal: JAMA Psychiatry (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Approaches to investigating common bleeding disorders: An evaluation of North American coagulation laboratory practices
Authors: Catherine P.M. Hayward, Karen A. Moffat, Elizabeth Plumhoff, Elizabeth M. Van Cott
Journal: American Journal of Hematology (2012)

Bleeding disorders commonly result from deficiencies or defects in von Willebrand factor (VWF), platelets, coagulation factors, or fibrinolytic proteins. The primary goal of our study was to assess current North American coagulation laboratory practices for diagnosing bleeding disorders, using an on-line patterns-of-practice survey of diagnostic laboratory members of the North American Specialized Coagulation Laboratory Association. The survey examined laboratory approaches to evaluating bleeding disorders, with specific questions about the tests and test panels offered and compliance to recent guideline recommendations on diagnosing von Willebrand disease (VWD) and platelet function disorders. All laboratories responding to the survey performed a prothrombin time/international normalized ratio, an activated partial thromboplastin time, and coagulation factor assays, and many tested for VWD and platelet disorders. However, few laboratories had test panels that evaluated the more common bleeding disorders and few performed some assays, including VWF multimer assessments and assays for fibrinolytic disorders. Additionally, the cutoffs used by laboratories to diagnose type 1 VWD varied considerably, with only a minority following the National Heart Lung Blood Institute recommendations. In contrast, laboratories that tested for platelet function disorders mostly complied with aggregation testing recommendations, as published in the recent North American guidelines. Our results indicate that there are some gaps in the strategies used by laboratories to diagnose bleeding disorders that might be addressed by development of further guidelines and test algorithms that emphasize evaluations for common bleeding disorders. Laboratories may also benefit from guidelines on test interpretation, and external evaluation of their bleeding disorder testing strategies.
Patients should be given more information about drugs during consultations
Authors: T P Schofield
Journal: BMJ (1996)

EDITOR,—In her editorial Barbara Meredith describes the information that consumer organisations may require to be able to advise consumers about drugs.1 We recently studied 271 videotaped consultations by general practitioners in the Oxford region in which a new prescription was given.2 A large majority of the patients (232) indicated that they got most of their …
Indications for tonsillectomy.
Authors: C. Holborow
Journal: BMJ (1969)

in which the subject of awareness during anaesthesia was discussed.Out of a total of 1,328 cases that I have recently anaesthetized, five cases have volunteered details of their operative experience indicating awareness.Three of these cases received nitrous-oxide-oxygen and relaxant anaesthesia-two out of a total of 25 caesarean sections and one case of multiple injuries.