tbuckley/cabot-search huggingface dataset:
Esophageal Ulcers in AIDS
Authors: Louis-Jean Couderc
Journal: Annals of Internal Medicine (1996)

Letters15 May 1996Esophageal Ulcers in AIDSLouis-Jean Couderc, MD, Evelyne Balloul, MD, and Isabelle Caubarrere, MDLouis-Jean Couderc, MDHopital Foch; 92150 Suresnes, France, Evelyne Balloul, MDHopital Foch; 92150 Suresnes, France, and Isabelle Caubarrere, MDHopital Foch; 92150 Suresnes, FranceAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Wilcox and colleagues [1] documented the high prevalence of idiopathic esophageal ulcers in patients with human immunodeficiency virus (HIV) infection and suggested that steroids be used in these patients. We previously reported that thalidomide was beneficial for esophageal ulceration and the HIV wasting syndrome [2, 3]. With treatment, the symptoms of aphthous ulceration, myalgia, and fever abated within 2 weeks. The patients required prolonged maintenance therapy because of recurrence when the daily thalidomide dose was tapered from 100 mg to 50 mg. No neurologic adverse effects occurred, although patients were treated simultaneously with azidothimidine. We suggest that ...References1. Wilxox CM, Schwartz DA, Clark WS. Esophageal ulceration in human immunodeficiency virus infection. Causes, response to therapy, and long-term outcome. Ann Intern Med. 1995; 122:143-9. Google Scholar2. Couderc LJ, Mathez D, Leibowitch J, Autran B, Caubarrere I. Traitement prolonge par thalidomide chez un malade infecte par le VIH [Letter]. Presse Medicale. 1995; 24:40. Google Scholar3. Couderc LJ, Autran B, Mathez D, Zucman D, Leibowitch J, Caubarrere I. Thalidomide in wasting syndrome of AIDS [Abstract]. Fourth European Conference on Clinical Aspects and Treatment of HIV Infection, Milan, Italy; March 1994. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hopital Foch; 92150 Suresnes, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThalidomide, a drug which may protect the organism against some aggressive effects of the immunologic systemAIDS Aware 15 May 1996Volume 124, Issue 10Page: 928-928KeywordsAIDSDrugsFeversHIVHIV infectionsMyalgiaPatientsPeripheral neuropathySteroidsUlcers Issue Published: 15 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Tc-99m MDP Uptake in a Case of Hepatoblastoma
Authors: A H Elgazzar, S Jahan, S Motawi, H M Abdel-Dayem
Journal: Clinical Nuclear Medicine (1989)

ELGAZZAR, A. H. M.D.; JAHAN, S. M.D.; MOTAWI, S. M.D.; ABDEL-DAYEM, H. M. M.D. Author Information
Effects of a structured educational intervention on knowledge and emergency management in patients at risk for anaphylaxis
Authors: K. Brockow, S. Schallmayer, K. Beyer, T. Biedermann, J. Fischer, N. Gebert, M. Grosber, T. Jakob, L. Klimek, C. Kugler, L. Lange, O. Pfaar, B. Przybilla, E. Rietschel, F. Rueff, S. Schnadt, R. Szczepanski, M. Worm, J. Kupfer, U. Gieler, J. Ring
Journal: Allergy (2014)

Structured educational programmes for patients at risk for anaphylaxis have not yet been established. Patients and caregivers often lack adequate skills in managing the disease.To investigate effects of structured patient education intervention on knowledge, emergency management skills and psychological parameters in patients with previous episodes of anaphylaxis and caregivers of affected children 95 caregivers (11 male, 84 female, mean age 37 years) of affected children and 98 patients (32 male, 66 female, mean age 47.5 years) were randomly assigned to an intervention (IG) or control group (CG) in a multicentre randomized controlled trial. The IG received two 3-h schooling modules of group education; the CG received standard auto-injector training only. Knowledge of anaphylaxis and emergency management competence in a validated training anaphylaxis situation as main outcome measures as well as secondary psychological parameters were assessed at baseline and 3 months after intervention.In comparison with controls, the intervention led to significant improvement of knowledge from baseline to 3-month follow-up (caregivers: IG 3.2/13.2 improvement/baseline vs CG 0.7/12.6; P < 0.001; patients: IG 3.9/10.8 vs 1.3/12.6; P < 0.001). Moreover, emergency management competence was increased after intervention as compared to controls (caregivers: IG 8.6/11.2 vs CG 1.2/10.8; P < 0.001; patients: 7.1/11.0 vs 1.1/11.1; P < 0.001). Intervention showed significant reduction of caregiver anxiety (-1.9/8.4 vs -0.7/7.5; P < 0.05). There were no significant changes in the depression scores.Structured patient education programmes may be beneficial in the management of anaphylaxis by increasing patients' empowerment to prevent and treat the disease.
Facing the NIH Funding Crisis
Authors: Robert Hromas, Janis L. Abkowitz, Armand Keating
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner
Authors: Rita I. Azevedo, Maria Vieira D. Soares, João T. Barata, Rita Tendeiro, Ana Serra-Caetano, Rui M. M. Victorino, Ana E. Sousa
Journal: Blood (2008)
Abstract LB-146: Identification of copy number alterations in small cell lung cancer
Authors: Alison L. Dooley, Monte M. Winslow, Derek Chiang, Shantanu Banerji, Charles Whittaker, Roderick Bronson, Denise Crowley, Matthew Meyerson, Tyler Jacks
Journal: Cancer Research (2010)

Abstract Small cell lung cancer (SCLC) comprises 20% of all lung cancer cases and is a particularly malignant disease. The identification of genomic alterations in small cell tumors and metastases and characterization of the genes within those regions will aid in our understanding of SCLC development and progression. DNA copy number gains and losses in human and mouse tumors frequently highlight genes of functional importance. Mouse tumors are often less genomically complex than their human counterparts and several recent studies have highlighted the power of comparative genomic studies of mouse models to identify genes relevant to human tumor progression. In a mouse model, inactivation of p53 and Rb following Cre-mediated recombination results in the development of lung tumors that resemble human SCLC histopathologically. Using this model of malignant SCLC, we have identified DNA copy number alterations in tumors and metastases using Illumina's Solexa massively parallel DNA sequencing technology. While the majority of the genome is unaltered, we observed several focal deletions and high-level amplifications. We detected an amplification of a region including the gene L-myc, a gene previously identified to be amplified in SCLC, and a region including Nuclear Factor 1/B (Nfib). Additionally, several cell lines derived from these lung tumors and metastases have high-level amplifications of Nfib. The DNA copy number data will be probed for conserved changes in tumors and metastases isolated from different animals and functionally validated using in vitro and in vivo assays. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-146.
Book: On The Natural History of Destruction
Authors: F. Charatan
Journal: BMJ (2003)

W G Sebald; translated by Anthea Bell Hamish Hamilton, £16.99, pp 205 ISBN 0 241 14126 5 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> This final work by W G Sebald, late professor of European literature at the University of East Anglia in Norwich, is strikingly relevant, when “smart” bombs and missiles nowadays supposedly avoid “collateral damage.” Its primary subject is literature and the Allied air raids on Germany during the second world war, but it is just as much about the psychopathology of destructiveness, repression in the mass memory of succeeding generations, … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Handbuch der Haut- und Geschlechtskrankheiten. J. Jadassohn. Ergänzungswerk. Band 4, Teil 4. Die Pilzkrankheiten der Haut durch Hefen, Schimmel, Aktinomyceten und verwandte Erreger.
Authors: Stephen Rothman
Journal: JAMA (1963)

In the monumental "supplement" to Jadassohn's Handbuch (1927-1934) our knowledge of skin and venereal diseases is brought up to date. The present 800-page section deals with fungus diseases of man caused by yeasts, molds, actinomycetes and related organisms, exclusive of dermatophytes ("ringworm" fungi). As it should be in the age of the airplane when continents are separated only by a few hours, ample space is devoted to exotic, particularly tropical fungus, diseases. The space, however, is not always advantageously allocated: Such widespread and significant diseases as histoplasmosis and North American blastomycosis are dealt with in only short—though good—chapters, while South American blastomycosis and chromoblastomycosis are discussed in minute detail. Not all the chapters are equally up-to-date: the fine contribution of Fernando Latapi of Mexico on mycetoma (Madura foot, etc.) utilizes the most modern terms and findings, while an unnecessarily overlapping chapter on nocardiosis uses antiquated nomenclature. The revolutionary work of
FDG PET Imaging of Metastatic Gastrointestinal Stromal Tumor
Authors: Mark D Wilkinson, Michael J. Fulham
Journal: Clinical Nuclear Medicine (2003)

A 75-year-old woman presented with an 8-month history of progressive abdominal distension and associated weight loss. Computed tomography (CT) showed a very large, partially enhancing, cystic/solid mass within the abdomen that extended from below the left diaphragm to the pelvis. A large (10 cm), partially enhancing lesion was also seen in segments 6 and 7 of the right lobe of the liver, consistent with metastatic disease. The patient underwent laparotomy and resection of a 5.7-kg abdominal tumor measuring 30 x 27 x 20 cm. Histology confirmed a gastrointestinal stromal tumor (GIST) of stomach origin. A whole-body F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) scan performed 2 months postoperatively demonstrated multiple glucose-avid lesions in the liver as well as residual disease within the abdomen and pelvis. The patient was referred to medical oncology. The authors give a brief overview of this rare mesenchymal tumor of the gastrointestinal tract and the potential role of PET.
Combined effects of global change pressures on animal-mediated pollination
Authors: Juan P. González-Varo, Jacobus C. Biesmeijer, Riccardo Bommarco, Simon G. Potts, Oliver Schweiger, Henrik G. Smith, Ingolf Steffan-Dewenter, Hajnalka Szentgyörgyi, Michał Woyciechowski, Montserrat Vilà
Journal: Trends in Ecology & Evolution (2013)
Fallibility of the Clinical Diagnosis of Venous Thrombosis
Authors: Robert W. Barnes
Journal: JAMA (1975)

Doppler ultrasound examination confirmed the diagnosis of acute venous thrombosis in only 194 (37%) of 527 patients. Of the remaining 333 patients, 245 (74%) had some other evident cause of the limb complaints. The postphlebitic stasis syndrome; symptomatic varicose veins; congestive heart failure; leg trauma; venous or lymphatic obstruction by malignancy; cellulitis or lymphangitis; arthritis; and pregnancy were etiologic factors in these patients. The proved inaccuracy of the bedside diagnosis of leg vein thrombosis stresses the need for accurate objective verification of venous disease before committing the patient to a full course of anticoagulant therapy. For most clinicians, a contrast phlebogram is the most available and reliable diagnostic procedure.
Public health in China.
Authors: A J Smith
Journal: BMJ (1974)

Acupuncture and barefoot doctors may be the current talk ing points in any Western discussion of medicine in China, but in fact probably the most important achievements made in the years of Communist rule have been in the field of public health. Many infectious and parasitic diseases have been eliminated and others brought under control. Sixteen days spent in a country the size of China does not really give time for even a superficial impression; and necessarily much of the information we required came from conversa tions with our hosts rather than from our own observations. However, a great deal of information on methods and results has been published'-3 in the last few years, and it is true to say that we saw nothing to contradict the claims made by the Chinese health authorities.
Human neutrophils employ chlorine gas as an oxidant during phagocytosis.
Authors: S L Hazen, F F Hsu, D M Mueller, J R Crowley, J W Heinecke
Journal: Journal of Clinical Investigation (1996)

Reactive oxidants generated by phagocytes are of central importance in host defenses, tumor surveillance, and inflammation. One important pathway involves the generation of potent halogenating agents by the myeloperoxidase-hydrogen peroxide-chloride system. The chlorinating intermediate in these reactions is generally believed to be HOCl or its conjugate base, ClO-. However, HOCl is also in equilibrium with Cl2, raising the possibility that Cl2 executes oxidation/ halogenation reactions that have previously been attributed to HOCl/ClO-. In this study gas chromatography-mass spectrometric analysis of head space gas revealed that the complete myeloperoxidase-hydrogen peroxide-chloride system generated Cl2. In vitro studies demonstrated that chlorination of the aromatic ring of free L-tyrosine was mediated by Cl2 and not by HOCl/ClO-. Thus, 3-chlorotyrosine serves as a specific marker for Cl2-dependent oxidation of free L-tyrosine. Phagocytosis of L-tyrosine encapsulated in immunoglobulin- and complement-coated sheep red blood cells resulted in the generation of 3-chlorotyrosine. Moreover, activation of human neutrophils adherent to a L-tyrosine coated glass surface also stimulated 3-chlorotyrosine formation. Thus, in two independent models of phagocytosis human neutrophils convert L-tyrosine to 3-chlorotyrosine, indicating that a Cl2-like oxidant is generated in the phagolysosome. In both models, synthesis of 3-chlorotyrosine was inhibited by heme poisons and the peroxide scavenger catalase, implicating the myeloperoxidase-hydrogen peroxide system in the reaction. Collectively, these results demonstrate that myeloperoxidase generates Cl2 and that human neutrophils use an oxidant with characteristics identical to those of Cl2 during phagocytosis. Moreover, our observations suggest that phagocytes exploit the chlorinating properties of Cl2 to execute oxidative and cytotoxic reactions at sites of inflammation and vascular disease.
Spinal injury in sports
Authors: R C Mishra
Journal: British Journal of Sports Medicine (2010)

Nowadays, the scene of sports has changed as it involves not only money but prestige for self and country. Hence, sports has become aggressive. Any sport which involves movement and momentum can cause spinal injury, like football, water sports, wrestling, rugby, transpoling and ice hockey. Spinal injury can be simple to serious leading to paralysis or death. The team physician should: Identify the injury Stabilise the athlete Transport the athlete to a proper centre. Above all, the team physician should be able to explain the prevention of spinal injury.
Magnetic resonance imaging and quantification of targeted drug delivery to vascular cells with paramagnetic perfluorocarbon nanoparticles
Authors: Gregory M. Lanza, Dana R. Abendschein, Xin Yu, Patrick M. Winter, Michael J. Scott, Ralph W. Fuhrhop, David E. Scherrer, Samuel A. Wickline
Journal: Journal of the American College of Cardiology (2002)
Therapeutic Strategies in Gastric Cancer
Authors: J.E.L. Wong
Journal: Journal of Clinical Oncology (2003)

Gastric cancer continues to be a major public health problem and is the second most common cause of cancer-related deaths in the world. These statistics led the American Society of Clinical Oncology (ASCO) International Affairs Committee to choose gastric cancer as the topic for the International Symposium held at the 2003 ASCO Annual Meeting. Dr Yoshiaki Ito will discuss the role of RUNX3 in the genesis and progression of human gastric cancer. Dr Pelayo Correa will present a compelling argument on the use of Helicobacter pylori therapy and antioxidants in selected high-risk population as chemoprevention strategies for gastric cancer. The controversy regarding the role of extended lymph node dissection for gastric cancer will be discussed by Dr Cornelis J.H. Van De Velde and Dr Mitsuru Sasako. Dr Van De Velde will present the European surgical approach to gastric cancer, and Dr Sasako will review the Japanese experience. The issues of whether certain patients benefit from more aggressive surgical dissection and the potential risks compared with benefits will also be discussed. Dr John Macdonald will discuss the role of adjuvant chemotherapy and adjuvant chemoradiotherapy in resected gastric cancer, as well as the role of chemotherapy in metastatic gastric cancer.
Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV
Authors: Renate G. van der Molen, Dave Sprengers, Paula J. Biesta, Johannes G. Kusters, Harry L. A. Janssen
Journal: Hepatology (2006)

In patients with chronic hepatitis B virus (HBV), 2 predominant precursor dendritic cell (DC) subtypes, the myeloid dendritic cell (mDC) and the plasmacytoid dendritic cell (pDC), were recently found to be functionally impaired. HBV DNA was found to be present in the DC subtypes, but no viral replication could be detected. The question remains whether simply the presence of the virus and viral proteins causes this dysfunction of DCs. To address this issue, the effect of viral load reduction resulting from treatment with the nucleotide analogue adefovir dipivoxil on the number and functionality of circulating DCs was studied during 6 months of treatment. Treatment resulted in a mean 5 log10 decrease in the viral load and normalization of alanine aminotransferase within 3 months. The number of mDCs, but not of pDCs, increased significantly over 6 months of treatment to a level comparable to that of uninfected healthy controls. The allostimulatory capacity of isolated and in vitro matured mDCs increased significantly after 3 months of treatment. Accordingly, mDCs exhibited an increased capacity to produce tumor necrosis factor alpha and interleukin-12 after 3-6 months of treatment. There was no change in interferon alpha production by pDCs during treatment. In conclusion, adefovir treatment results in an improvement in the number and functionality of mDCs, but not of pDCs. Our findings provide clues for the reasons why current antiviral therapy does not lead to consistently sustained viral eradication. (HEPATOLOGY 2006;44:907–914.)
Possible Hepatotoxicity of Doxidan®
Authors: KEITH G. TOLMAN
Journal: Annals of Internal Medicine (1976)

A patient with chronic constipation developed liver injury and leukopenia following the ingestion of Doxidan®, a combination drug consisting of danthron and dioctyl calcium sulfosuccinate. Evidence is presented that dioctyl calcium sulfosuccinate may have potentiated the toxicity. The liver injury was associated with deposition of IgE in the Kupffer cells. The mechanism of toxicity remains unclear.
Cellular immunity and IgE levels in atopic patients
Authors: M. Frajman, L. González, A. Alvarado, J. Yock
Journal: Allergy (1987)

Twenty young adult atopic patients and their matched controls were studied. Spontaneously generated and Con‐A‐induced suppressor T cell functions as well as Natural Killer (NK) activity against K‐562 target cells, measured in a short‐time 3H‐thvmidine uptake were evaluated suppressor T cell activity in the patients was more than 2 SD lower than that found in the controls and there was, contrary to expectation, a direct correlation between suppressor function and serum IgE levels. Atopic patients showed a statistically significant lower NK activity than normal controls when related to a low IL‐2 production, Both facts inversely correlated with the concentration of IgE in serum. We concluded that atopic patients' vulnerability to viral infections may be due to defective NK activity. Suppressor T cell function is abnormal in these patients. Both defects could be due to a faulty immunoregulatory helper function.
FcγRIII (CD16) equips immature 6-sulfo LacNAc–expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens
Authors: Thomas Döbel, Anja Kunze, Jana Babatz, Katja Tränkner, Andreas Ludwig, Marc Schmitz, Alexander Enk, Knut Schäkel
Journal: Blood (2013)
Pituitary-adrenal responses to human corticotropin-releasing hormone in critically ill patients
Authors: Ioanna Dimopoulou, Panagiota Alevizopoulou, Urania Dafni, Stylianos Orfanos, Olga Livaditi, Marinella Tzanela, Anastasia Kotanidou, Emmanouil Souvatzoglou, Petros Kopterides, Irini Mavrou, Nikolaos Thalassinos, Charis Roussos, Apostolos Armaganidis, Stylianos Tsagarakis
Journal: Intensive Care Medicine (2006)