Transplantation of the Spleen
Authors: John C. Norman, Victor H. Covelli, Herbert S. Sise
Journal: Annals of Internal Medicine (1968)

Editorials1 March 1968Transplantation of the SpleenJOHN C. NORMAN, M.D., VICTOR H. COVELLI, M.D., HERBERT S. SISE, M.D., F.A.C.P.JOHN C. NORMAN, M.D.Search for more papers by this author, VICTOR H. COVELLI, M.D.Search for more papers by this author, HERBERT S. SISE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-3-700 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOn February 24, 1908, Alexis Carrel removed the spleen from a large yellow dog, "in poor health." The spleen was washed in and perfused with Locke's solution. After forty-four minutes, the spleen had been replaced [orthotopically] and circulation re-established. In June at re-exploration, the organ appeared normal. In November, following accidental death at the animal farm, "the histology of the [autotransplanted] spleen appeared normal." A companion experiment failed because of technical problems. Carrel stated that "from a surgical standpoint, the problem of the graft of organs (spleen and kidney) can be considered as having been solved. But, from a biological...References1. RUSSELLMONACO PSA: The Biology of Tissue Transplantation. Little, Brown and Co., Boston, 1964, p. 4. Google Scholar2. CARREL A: Remote results of the replantation of the kidney and the spleen. J. Exp. Med. 12: 146, 1910. CrossrefMedlineGoogle Scholar3. SIMONSENBUEMANNGRAMMELTOFTJENSENJORGENSEN MJAFK: Biological incompatibility in kidney transplantation in dogs. I. Experimental and morphological investigations. Acta Path. Microbiol. Scand. 32: 1, 1953. CrossrefMedlineGoogle Scholar4. SIMONSEN M: Biological incompatibility in kidney transplantation in dogs. II. Serological investigations. Ibid., p. 36. Google Scholar5. MANLEYMARINE OTD: The transplantation of splenic tissue into the subcutaneous fascia of the abdomen in rabbits. J. Exp. Med. 25: 619, 1917. CrossrefMedlineGoogle Scholar6. PERLAMARMORSTON-GOTTESMAN D: Studies on Bartonella muris anemia of albino rats. III. The protective effect of autoplastic splenic transplants on the Bartonella muris anemia of splenectomized rats. J. Exp. Med. 52: 131, 1930. CrossrefMedlineGoogle Scholar7. JANDLASTER JHRH: Increased splenic pooling and the pathogenesis of hypersplenism. Amer. J. Med. Sci. 253: 27, 383, 1967. CrossrefMedlineGoogle Scholar8. JANDLFILESBARNETTMACDONALD JHNMSBRA: Proliferative response of the spleen and liver to hemolysis. J. Exp. Med. 122: 299, 1965. CrossrefMedlineGoogle Scholar9. JACOBMACDONALDJANDL HSRAJH: Regulation of spleen growth and sequestering function. J. Clin. Invest. 42: 1476, 1963. CrossrefMedlineGoogle Scholar10. WHEELERBALANKURAPENDOWERGREENBERGDAMMINMOORE HBOJEJBGJFD: The homograft response to whole-organ transplantation of the canine spleen. J. Surg. Res. 2: 114, 1962. CrossrefMedlineGoogle Scholar11. LILLEHEILONGERBEAMHILALYUNIS RCJKSE: Studies on the treatment of acute radiation sickness in dogs with various preparations of spleen. Surgery 48: 716, 1960. MedlineGoogle Scholar12. MONTAGUEGREENBERGDAMMINMOORE ACJBGJFD: The effect of nitrogen mustard in altering the histocompatibility rejection sequence in splenic homotransplantation in the dog. J. Surg. Res. 2: 130, 1962. CrossrefMedlineGoogle Scholar13. SIMONSEN M: Graft versus host reactions. Their natural history, and applicability as tools of research. Progr. Allerg. 6: 349, 1962. MedlineGoogle Scholar14. BILLINGHAM RE: Reactions of grafts against their hosts. Science 130: 947, 1959. CrossrefMedlineGoogle Scholar15. BILLINGHAMBRENT REL: Simple method for inducing tolerance of skin homografts in mice. Transplant. Bull. 4: 67, 1957. MedlineGoogle Scholar16. MARCHIOROROWLANDSRIFKINDWADDELLSTARZL TLDTDWRTE: Splenic homotransplantation. Ann. N.Y. Acad. Sci. 120: 626, 1964. CrossrefMedlineGoogle Scholar17. KOUNTZCOHN SLR: Prolonged survival of a renal homograft by simultaneous splenectomy and splenic homotransplantation. Surg. Forum 13: 59, 1962. MedlineGoogle Scholar18. NORMANLAMBILLIOTTEKOJIMASISE JCJYHS: Antihemophilic factor release by perfused liver and spleen: new relationships to hemophilia. Science 158: 1060, 1967. CrossrefMedlineGoogle Scholar19. NORMANCOVELLISISE JCVHHS: Transplantation of the spleen: persisting experimental cure of hemophilia. Surgery. In press. Google Scholar20. GOWANSKNIGHT JLEJ: The route of recirculation of lymphocytes in the rat. Proc. Roy. Soc. Biol. 159: 257, 1964. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMilz und BlutgerinnungHaemostasis in kala-azar 1 March 1968Volume 68, Issue 3Page: 700-704KeywordsHistologyRenal transplantationSpleenTransplantation Issue Published: 1 March 1968 PDF DownloadLoading ...