Ciprofloxacin versus Tobramycin for Neutropenic Fevers
Authors: Darren R. Linkin, Neil Fishman
Journal: Annals of Internal Medicine (2003)

Letters4 March 2003Ciprofloxacin versus Tobramycin for Neutropenic FeversDarren R. Linkin, MD and Neil Fishman, MDDarren R. Linkin, MDUniversity of Pennsylvania; Philadelphia, PA 19104 (Linkin, Fishman)Search for more papers by this author and Neil Fishman, MDUniversity of Pennsylvania; Philadelphia, PA 19104 (Linkin, Fishman)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-5-200303040-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:From the introduction and discussion in Peacock and colleagues' article on piperacillintobramycin versus piperacillin-ciprofloxacin (1), the reader is left with the impression that combination therapy is favorable to monotherapy for neutropenic fever. The authors noted that combination antibiotic therapy has been used for neutropenic fever since the 1970s. However, most studies have failed to show a difference in efficacy between combination therapy and monotherapy (2). Several reviews and guidelines, including those referenced by Peacock and colleagues, recommend monotherapy for uncomplicated neutropenic fever and monotherapy or combination therapy for more complicated cases (2, 3).The authors state, Although ...References1. Peacock JE, Herrington DA, Wade JC, Lazarus HM, Reed MD, Sinclair JW, . Ciprofloxacin plus piperacillin compared with tobramycin plus piperacillin as empirical therapy in febrile neutropenic patients. A randomized, double-blind trial. Ann Intern Med. 2002;137:77-87. [PMID: 12118962] LinkGoogle Scholar2. Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandra T, . 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis. 2002;34:730-51. [PMID: 11850858] CrossrefMedlineGoogle Scholar3. Pizzo PA. Fever in immunocompromised patients. N Engl J Med. 1999;341:893-900. [PMID: 10486422] CrossrefMedlineGoogle Scholar4. Mebis J, Goossens H, Bruyneel P, Sion JP, Meeus I, Van Droogenbroeck J, . Decreasing antibiotic resistance of Enterobacteriaceae by introducing a new antibiotic combination therapy for neutropenic fever patients. Leukemia. 1998;12:1627-9. [PMID: 9766509] CrossrefMedlineGoogle Scholar5. Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Johnson MP, . Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med. 1991;115:585-90. [PMID: 1892329] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Darren R. Linkin, MD; Neil Fishman, MDAffiliations: University of Pennsylvania; Philadelphia, PA 19104 (Linkin, Fishman) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCiprofloxacin plus Piperacillin Compared with Tobramycin plus Piperacillin as Empirical Therapy in Febrile Neutropenic Patients James E. Peacock Jr. , Deirdre A. Herrington , James C. Wade , Hillard M. Lazarus , Michael D. Reed , Jane W. Sinclair , Daniel C. Haverstock , Steven F. Kowalsky , David D. Hurd , Deborah A. Cushing , Colleen P. Harman , and Gerald R. Donowitz Ciprofloxacin versus Tobramycin for Neutropenic Fevers Gerald R. Donowitz and James E. Peacock Jr. Ciprofloxacin versus Tobramycin for Neutropenic Fevers Gerald P. Bodey , Kenneth V.I. Rolston , and Issam I. Raad Metrics 4 March 2003Volume 138, Issue 5Page: 435-436KeywordsAdverse reactionsAntibioticsAntimicrobial resistanceAntimicrobialsFeversHyperthermiaToxicity ePublished: 4 March 2003 Issue Published: 4 March 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...