tbuckley/cabot-search huggingface dataset:
Surface immunoglobulins on hairy cells of 55 patients with hairy cell leukemia
Authors: Harvey M. Golomb, Susan Davis, Carol Wilson, James Vardiman
Journal: American Journal of Hematology (1982)

Abstract Surface immunoglobulins (SIg) were determined on peripheral blood samples from 55 patients with hairy cell leukemia (HCL) and on hairy cells from spleen preparations of 14 of these 55 patients. The patterns of SIg for HCL was compared to the patterns on peripheral blood leukemic cells from 39 patients with chronic lymphocytic leukemia (CLL) and 15 patients with poorly differentiated lymphocytic (PDL) lymphoma. Of the 55 HCL patients, 42 could be scored for individual heavy and light chains; 16 had only IgG, 14 had two or three heavy chains, 7 had only IgD, and 5 cases had no SIg and were E‐rosette negative. This pattern was different from the B‐cell pattern in CLL and PDL where there were few cases of IgG alone (5%) and many cases of IgM alone (50%). Surface marker profile did not correlate with survival in any of the sub‐groups tested. HCL appears to be a B‐cell lymphoproliferative disease in greater than 90% of cases; many combinations of heavy chains with only a single light chain can be demonstrated.
Preventing diarrhoea should be global priority, says WHO
Authors: R. Dobson
Journal: BMJ (2009)

The prevention and treatment of diarrhoea must become an international priority if the number of deaths from diarrhoea and overall child mortality are to be reduced, says a new report.

More than four years after new recommendations for treatment, diarrhoea remains the second leading cause of death among children, and few children in developing countries are receiving these lifesaving interventions, says the report ( Bulletin of the World Health Organization doi:10.2471/BLT.08.058990).

“Diarrhoea continues to kill nearly two million children each year, leads to …
Safety of e-cigarettes still needs to be proved
Authors: Chris Valentine, Paul Nicholson
Journal: BMJ (2014)

Minerva issues a call to arms for health professionals to recommend e-cigarettes to people who wish to stop smoking.1 Our experience is that unexpected consequences occasionally follow from well intentioned substitution of hazardous substances. Lead paints, solvents, and asbestos were all once regarded as safe.

Every year children die after consuming methadone prescribed to help their parents’ heroin addiction.2 …
Sympathetic Nerve Activity in the Congenital Long-QT Syndrome
Authors: Abu S.M. Shamsuzzaman, Michael J. Ackerman, Tomas Kara, Paola Lanfranchi, Virend K. Somers
Journal: Circulation (2003)

Patients with congenital long-QT syndrome (LQTS) are susceptible to life-threatening arrhythmias. The sympathetic nervous system may have an important triggering role for cardiovascular events in LQTS. We therefore examined measurements of sympathetic neural traffic in patients with LQTS and matched control subjects.Twelve patients with congenital LQTS and 12 healthy volunteers matched for age, sex, and body mass index were studied. Heart rate, respiration, blood pressure, and sympathetic nerve activity to the skeletal muscle blood vessels (muscle sympathetic nerve activity) and to the skin (skin sympathetic nerve activity) were monitored and recorded continuously. Resting heart rate (P=0.03), muscle sympathetic nerve activity burst rate (P=0.008), and burst incidence (P=0.02) were lower in patients with LQTS than in control subjects. However, skin sympathetic nerve activity was very similar in patients with LQTS and control subjects. Spectral analysis of RR variability showed a decreased low-frequency component, an increased high-frequency component, and a decrease in the ratio of the low-frequency component to the high-frequency component in patients with LQTS (P=0.01).LQTS is associated with a selective reduction in sympathetic drive to muscle blood vessels and perhaps also to the heart.
Variations in purine metabolism of cultured skin fibroblasts from patients with gout
Authors: J. Frank Henderson, Frederick M. Rosenbloom, William N. Kelley, J. Edwin Seegmiller
Journal: Journal of Clinical Investigation (1968)

Purine metabolism was studied in fibroblasts cultured from three patients with gout in an attempt to determine the biochemical bases of their disease. The rate of purine biosynthesis de novo was normal in one line of cells, but the rate of catabolism of adenine nucleotides to hypoxanthine and inosine was greatly increased. The rate of purine biosynthesis de novo was increased in two lines of cells, and this was associated with increased concentrations of 5-phosphoribosyl 1-pyrophosphate. Purine synthesis was also less sensitive than normal to feedback inhibition. The catabolism of inosinate synthesized de novo was increased.
CARELESSNESS IN PHARMACY AS A REASON FOR A RESTRICTED MATERIA MEDICA
Authors: M. I. WILBERT
Journal: JAMA (1913)

The federal Food and Drugs Act, June 30, 1906, and the several state laws of a similar nature that have become operative during recent years have served to stimulate the interest of federal and state officials in regard to the nature and composition of the medicines that are being dispensed in the drug-stores throughout the country. In connection with the compilation of material for the "Digest of Comments on the Pharmacopeia of the United States of America and the National Formulary," now being published by the Public Health Service of the United States, an effort is being made to reflect the published results of these several inquiries. For various reasons, largely because of the difficulties involved in making the necessary chemical examinations, the number or variety of drugs and preparations reported on at all frequently is rather limited, but sufficient material is available to suggest some necessary changes in the
Extrapleural pneumonectomy in malignant pleural mesothelioma
Authors: O. Rena
Journal: BMJ (2011)

Should be limited only to patients enrolled in trials, according to new trial evidence

The asbestos related cancer, malignant mesothelioma, is a major health problem worldwide. The European epidemic is expected to peak within the next decade, with about 250 000 deaths predicted, mostly from malignant pleural mesothelioma.1

Malignant pleural mesothelioma is a diffuse cancer that spreads along the pleura and causes breathlessness, severe chest pain, and cachexia. The search for curative and palliative treatments is ongoing. The tumour is radiation sensitive, but its pattern of growth (surrounding the lung, being close to the heart, spinal cord, and other organs; and its large surface area rather than localised bulk) makes it difficult to deliver sufficiently high doses without causing serious damage.2 Sensitivity to chemotherapy is moderate, but a higher tumour regression rate (about 40%) has been obtained by the use of cisplatin and pemetrexed combined.3

Over the past 20 years extrapleural pneumonectomy has been used to maximise the therapeutic effects of chemotherapy and radiotherapy. When …
Evaluating the teaching of evidence based medicine: conceptual framework
Authors: Sharon E Straus, Michael L Green, Douglas S Bell, Robert Badgett, Dave Davis, Martha Gerrity, Eduardo Ortiz, Terrence M Shaneyfelt, Chad Whelan, Rajesh Mangrulkar
Journal: BMJ (2004)

Although evidence for the effectiveness of evidence based medicine has accumulated, there is still little evidence on what are the most effective methods of teaching it.
Umbilical uptake of amino acids in the unstressed fetal lamb.
Authors: J A Lemons, E W Adcock, M D Jones, M A Naughton, G Meschia, F C Battaglia
Journal: Journal of Clinical Investigation (1976)

The whole blood concentrations of 22 amino acids were measured in a chronic, unstressed fetal lamb preparations. Samples were taken daily from the umbilical artery, umbilical vein, and maternal artery over the latter quarter of gestation. 73 sets of samples (from the umbilical artery and vein and the maternal artery) from 13 animals were analyzed for amino acid levels. Oxygen contents were determined simultaneously in 48 sets (umbilical artery and vein) to relate fetal oxygen consumption to amino acid uptake via the umbilical circulation. The results indicate that there is no umbilical uptake of the acidic amino acids, glutamate and aspartate; there is, in fact, a net flux of glutamate out of the fetus into the placenta. As both of these amino acids are major constituents of body proteins, the data indicate that they are formed within the fetus. The umbilical uptake of some neutral and basic amino acids (e.g., valine, leucine, isoleucine, arginine, phenylalanine, and tyrosine) is in considerable excess of estimated growth requirements, suggesting that some amino acids undergo extensive transamination and oxidative degradation in the fetus. Finally, the net uptake of nitrogen, carbon, and calories by the growing ovine fetus in the form of amino acids, glucose, and lactate is compared to estimated requirements as determined in previous studies.
Antiphospholipid antibodies (APLA) in immune thrombocytopenic purpura (ITP) and antiphospholipid syndrome (APS)
Authors: Carlos J. Bidot, Wenche Jy, Lawrence L. Horstman, Eugene R. Ahn, Miriam Yaniz, Yeon S. Ahn
Journal: American Journal of Hematology (2006)

Antiphospholipid antibodies (APLA) are associated with anti-phospholipid syndrome (APS), a thrombotic disorder, but they are also frequently detected in immune thrombocytopenic purpura (ITP), a bleeding disorder. To investigate possible differences of APLA between these two disorders, we assayed IgG and IgM APLA by ELISA in 21 patients with ITP and 33 with APS. The APLA reacting against two protein target antigens, β2-glycoprotein 1 (β2GP1) and FVII/VIIa, and four phospholipids [cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylethanolamine (PE)] as well as lupus anticoagulant (LA) were analyzed. We made the following observations: (i) IgG and IgM antibodies to β2GP1 and IgM antibodies to FVII/VIIa were more common in APS than ITP, P < 0.05, while IgG antibodies against the phospholipids (aCL, aPC, aPS, aPE) were more common in ITP than APS, P < 0.05; (ii) multiple APLA ≥3 antigens) were more frequent in APS than ITP, P < 0.05; (iii) LA was frequently associated with APS but was absent in ITP; (iv) APLA is quite common in ITP: two-thirds were positive for at least one APLA. In summary, APLA are prevalent in ITP but their profile differs from APS. In APS, antibodies were predominantly against β2GP1 and 80% had positive LA, while in ITP the APLA reacted most often with the phospholipids without LA. The difference in APLA may result in opposite clinical manifestations in two disorders. Am. J. Hematol. 81:391–396, 2006. © 2006 Wiley-Liss, Inc.
Apolipoprotein E, Neurodegeneration, and Alzheimer Disease
Authors: William Jagust
Journal: JAMA Neurology (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Immunogenicity and safety of the Vi-CRM197 conjugate vaccine against typhoid fever in adults, children, and infants in south and southeast Asia: results from two randomised, observer-blind, age de-escalation, phase 2 trials
Authors: Zulfiqar A Bhutta, Maria Rosario Capeding, Ashish Bavdekar, Elisa Marchetti, Shabina Ariff, Sajid B Soofi, Alessandra Anemona, Muhammad A Habib, Edison Alberto, Sanjay Juvekar, Rana M Qasim Khan, Rachid Marhaba, Noshad Ali, Nelia Malubay, Anand Kawade, Allan Saul, Laura B Martin, Audino Podda
Journal: The Lancet Infectious Diseases (2013)
Tc-99m Glucoheptonate Scintigraphy in a Case of Renal Vein Thrombosis
Authors: G N SFAKIANAKIS, G ZILLERUELO, T THOMPSON, W AL-SHEIKH, J STRAUSS
Journal: Clinical Nuclear Medicine (1985)

Tc-99m glucoheptonate flow and static studies with computer-assisted analysis provided specific diagnostic information in unilateral renal vein thrombosis complicating a case of nephrotic syndrome. Decreased flow with congestion, a large kidney with parenchymal thickening, pelvocalyceal thinning, good function, and no obstruction in the proper clinical settings indicated the diagnosis of a chronic form of renal vein thrombosis with compensating collateralization. The differential diagnosis is discussed.
Oestrogen treatment and endometrial carcinoma.
Authors: A R Feinstein, R I Horwitz
Journal: BMJ (1977)

A previous leading article on estrogen treatment and endometrial cancer is criticized for not showing scientific appraisal. There was a misunderstanding of the case-control approach. The reasoning is invalid because it is incomplete and misleading. There are 2 previous contradictory case-control studies in which no relationship was found between estrogens and endometrial cancer. Clinical events can create prescribor bias and produce detector bias to show a fallacious relationship. An undetected endometrial cancer may already have been present when the estrogen was prescribed for bleeding, or estrogen given for postmenopausal symptoms may have provoked bleeding that led to diagnostic curettage. Estrogen's alleged carcinogenicity awaits further scientific investigation.
Thromboxane A2 and prostaglandin F2α mediate inflammatory tachycardia
Authors: Koji Takayama, Koh-ichi Yuhki, Kyoichi Ono, Takayuki Fujino, Akiyoshi Hara, Takehiro Yamada, Shuhko Kuriyama, Hideji Karibe, Yuji Okada, Osamu Takahata, Takanobu Taniguchi, Toshihiko Iijima, Hiroshi Iwasaki, Shuh Narumiya, Fumitaka Ushikubi
Journal: Nature Medicine (2005)
Hypospadias and endocrine disruption: is there a connection?
Authors: L S Baskin, K Himes, T Colborn
Journal: Environmental Health Perspectives (2001)

Hypospadias is one of the most common congenital anomalies in the United States, occurring in approximately 1 in 250 newborns or roughly 1 in 125 live male births. It is the result of arrested development of the urethra, foreskin, and ventral surface of the penis where the urethral opening may be anywhere along the shaft, within the scrotum, or in the perineum. The only treatment is surgery. Thus, prevention is imperative. To accomplish this, it is necessary to determine the etiology of hypospadias, the majority of which have been classified as idiopathic. In this paper we briefly describe the normal development of the male external genitalia and review the prevalence, etiology, risk factors, and epidemiology of hypospadias. The majority of hypospadias are believed to have a multifactorial etiology, although a small percentage do result from single gene mutations. Recent findings suggest that some hypospadias could be the result of disrupted gene expression. Discoveries about the antiandrogenic mechanisms of action of some contemporary-use chemicals have provided new knowledge about the organization and development of the urogenital system and may provide additional insight into the etiology of hypospadias and direction for prevention.
Sapheno-femoral Junction
Authors: S. Alexander
Journal: BMJ (1964)

Aversion TherapySIR,-It is exasperating to still read of treatment with apomorphine referred to as aversion therapy.The late Dr. John Y. Dent, the originator of the modem version of this treatment, was of the opinion that apo- morphine has a direct action on the medulla and aversion has no part in the process.He explained fully the theory and technique in " Anxiety and its Treatment "' as well as in
Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poor-prognosis acute myeloid leukemia
Authors: G Visani, D Milligan, F Leoni, J Chang, S Kelsey, R Marcus, R Powles, S Schey, A Covelli, A Isidori, M Litchman, PP Piccaluga, H Mayer, M Malagola, C Pfister
Journal: Leukemia (2001)
Abstract LB-57: Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability.
Authors: Weihong Wen, Cong Peng, Ann M. Bode, Zigang Dong
Journal: Cancer Research (2013)

Abstract RNF2, also known as Ring1B/Ring2, is a component of the polycomb repression complex 1. RNF2 is highly expressed in many tumors, suggesting that it might have an oncogenic function, but the mechanism is unknown. Here, we show that knockdown of RNF2 significantly inhibits both cell proliferation and colony formation in soft agar, and induces apoptosis in cancer cells. Knockdown of RNF2 in HCT116 p53+/+ cells resulted in significantly more apoptosis than was observed in RNF2 knockdown HCT116 p53−/- cells, indicating that RNF2 knockdown-induced apoptosis is partially dependent on p53. Various p53-targeted genes were increased in RNF2 knockdown cells. Further studies revealed that in RNF2 knockdown cells, the p53 protein level was increased, the half-life of p53 was prolonged and p53 ubiquitination was decreased. In contrast, cells overexpressing RNF2 showed a decreased p53 protein level, a shorter p53 half-life and increased p53 ubiquitination. Importantly, we found that RNF2 directly binds with both p53 and MDM2 and promotes MDM2-mediated p53 ubiquitination. RNF2 overexpression could also increase the half-life of MDM2 and inhibit its ubiquitination. The regulation on p53 and MDM2 stability by RNF2 was also observed during the etoposide-induced DNA damage response. These results provide a possible mechanism explaining the oncogenic function of RNF2, and because RNF2 is important for cancer cell survival and proliferation, it might be an ideal target for cancer therapy or prevention. Citation Format: Weihong Wen, Cong Peng, Ann M. Bode, Zigang Dong. Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-57. doi:10.1158/1538-7445.AM2013-LB-57 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Characterization of two cases of acquired transitory von willebrand syndrome with ciprofloxacin: Evidence for heightened proteolysis of von willebrand factor
Authors: Giancarlo Castaman, Antonella Lattuada, Pier Mannuccio Mannucci, Francesco Rodeghiero
Journal: American Journal of Hematology (1995)

Abstract We characterized the cause of two cases of transitory acquired von Willebrand syndrome associated with the administration of ciprofloxacin. Purified lg from the two patients did not inhibit Ristocetin Cofactor activity or binding to collagen of normal plasma, ruling out the possibility of an inhibitor. The analysis of multimeric pattern of plasma von Willebrand Factor (vWF) showed the lack of larger multimers in both patients, with a relative decrease of all the remaining forms in the first patient. The subunit composition of plasma vWF showed a marked reduction of the native 225 Kd subunit (31.9% and 32.9%; normal range 74‐46%) and an increased proportion of the 189, 176, and 140 Kd fragments. These abnormalities disappeared during the follow‐up, without any specific therapy. In conclusion, a common pathophysiological basis is demonstrated in both patients, with a heightened proteolysis of plasma vWF by an unknown mechanism. © 1995 Wiley‐Liss, Inc.
Edvard Munch's Split Image-Reply
Authors: M. Therese Southgate
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ironie und Abwehr
Authors: H. Schneider
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 Ironie und Abwehr Subject Area: Psychiatry and Psychology H. Schneider H. Schneider Bern Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (5): 326–338. https://doi.org/10.1159/000285900 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation H. Schneider; Ironie und Abwehr. Psychother Psychosom 1 May 1967; 15 (5): 326–338. https://doi.org/10.1159/000285900 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.