tbuckley/cabot-search huggingface dataset:
Abstract 3791: Secreted plectin-rich exosomes from pancreatic cancer cells promote tumor aggressiveness.
Authors: Soo J. Shin
Journal: Cancer Research (2013)

Abstract Background &amp; Aims: We recently demonstrated that the aberrant extracellular localization of the cytoskeletal linker protein plectin is a robust biomarker for the progression of pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive malignancies. Exosomes are nanometer-sized particles containing cytoplasm and plasma membrane that are secreted by both normal and cancerous cells. Recently the importance of exosomes in cross-talk in the tumor microenvironment has been demonstrated. Fusion of exosomes to the cellular membrane in either a paracrine or autocrine manner can result in aberrant protein localization. Here, we assess the mechanism for plectin mislocalization and its functional role in PDAC. Methods: A plectin-binding assay was developed to assess the presence of cell-surface localized plectin. To examine their potential contribution to aberrant extracellular localization of plectin, we determined whether plectin was present in PDAC-secreted exosomes collected by ultracentrifugation and evaluated by immunoblotting. Based on these observations, we then determined whether exosomes with or without plectin altered gross phenotypic tumor characteristics in vitro in tumor stromal and endothelial cells. Finally, we tested the ability to alter outgrowth kinetics by directly injecting exosomes with or without plectin in tumors in vivo. Results: Plectin was localized on the cell surface as well as present in exosomes derived from PDAC cell lines but not from non-transformed human pancreatic ductal epithelial (HPDE) cells. Plectin presence in the exosomes hinged on the expression of integrin β4, a protein known to interact with cytosolic plectin. shRNA and overexpression studies collectively demonstrated a positive role of plectin and its localization in the exosomes in proliferation, migration, and invasion of PDAC cells and migratory capacity of microenvironment cells. Finally, plectin-rich exosomes enhanced in vivo tumor growth. Conclusions: Plectin is expressed in PDAC and is aberrantly localized to the cell surface via exosomes in an integrin β4-dependent manner. Additionally, plectin-rich exosomes induce pronounced increase in tumor growth in vitro and in vivo further they increased invasion and migration in vitro. Plectin-positive exosomes had profound effects on stromal and endothelial cells. Because cell surface plectin has been shown to be a biomarker for transition of pre-invasive to invasive PDAC, the elucidation of the mechanisms of its deregulation may provide important insights for successful detection and management of PDAC. Citation Format: Soo J. Shin. Secreted plectin-rich exosomes from pancreatic cancer cells promote tumor aggressiveness. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3791. doi:10.1158/1538-7445.AM2013-3791
Arthritis and Allied Conditions: A Textbook of Rheumatology
Authors: Ronenn Roubenoff
Journal: JAMA (1993)

This is the 12th edition of the textbook of rheumatology first published in 1940. Like its predecessors, it presents voluminous and authoritative material on all facets of rheumatic diseases, from paleopathology to molecular biology to clinical features and treatment. The 143 contributors represent many of the top academic rheumatology divisions and related fields in the United States and abroad. It is impractical to read tomes like this from cover to cover. Instead, I tried to put the textbook through its paces by reading the sections that were pertinent to my clinical practice over a four-week period. Thus, while I did not see every condition described in the book, I found that I covered a surprising amount of it, either directly in my own patients, or during teaching sessions with fellows, house staff, and students, and in discussions with colleagues. My bias is that a subspecialty textbook should have two purposes:
Biomarkers of Disease Severity and Th2 Polarity Are Predictors of Atopic Dermatitis Subjects Who Are Colonized with S. Aureus
Authors: Lisa A. Beck, Takeshi Yoshida, Anna De Benedetto, Seungshin Rhee, I-Hsin Kuo, Jamie Reese, Gloria David, Lynda C. Schneider, Amy Paller, Jon M. Hanifin, Mark Boguniewicz, Kathleen C. Barnes, Donald Y.M. Leung
Journal: Journal of Allergy and Clinical Immunology (2013)
Influence of Partnership on the Outcome of Psychotherapy
Authors: Astrid Riehl
Journal: Psychotherapy and Psychosomatics (1986)

30 patients who had psychosomatic disorders and were living constantly with the same partner were followed up 2–3 years after inpatient psychotherapy. The outcome of psychotherapy was assessed and the patients were interviewed about partnership and disease. The interviews were evaluated by 10 raters who had to score 26 variables. Using a discriminant analysis 4 variables were selected which predicted outcome correctly in 93.3% of the patients: (1) who leaves whom in case of separation; (2) partner's help in coping with illness guided by patient's needs; (3) cognitive reappraisal of the patient, and (4) changes in the extradyadic relation of the partner. The findings clearly demonstrate that the cognitions on partnership are connected with the outcome of psychotherapy to a substantial degree.
Edgar Williams Parry
Authors: A. Mansfield
Journal: BMJ (2011)

Advanced surgery for venous thrombosis



Edgar Parry’s key legacies are in the emerging specialty of vascular surgery, which has developed from its traditional role in sympathectomy, varicose veins, and amputations. In the 1950s opportunities arose to repair and replace diseased blood vessels, and this was what Parry decided to pursue.

In 1952 about 12% of the 78% of hospital deaths that were investigated by postmortem examination involved pulmonary emboli, a worryingly high incidence, especially in apparently fit patients after operation. Working with Professors Milnes Walker and T F Hewer in Bristol, Parry observed that the massive pulmonary emboluses almost always occurred in patients older than 40 after an operation. There was substantially increased risk in malignancy. Anticoagulants had been prescribed only in half of these patients, and Parry recognised the paucity and therefore unreliability of the clinical signs of deep vein thrombosis.

He saw that thrombuses were often bilateral and that the more proximal the thrombus the greater the risk of embolism—for example, 70% in femoral vein thrombuses and 30% in calf thrombuses. He also saw that in 10 limbs out of 104, clots were above the knee but not …
Psychiatric and Neuromuscular Manifestations in Primary Hyperparathyroidism.
Authors: Boy Frame
Journal: Annals of Internal Medicine (1964)

s1 October 1964Psychiatric and Neuromuscular Manifestations in Primary Hyperparathyroidism.Boy Frame, M.D., F.A.C.P., George Karpati, M.D.Boy Frame, M.D., F.A.C.P.Search for more papers by this author, George Karpati, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-812_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEndocrine disorders often cause mental and neuromuscular changes. Clinical analysis of 33 histologically proven cases of primary hyperparathyroidism (PHPT) was undertaken in an attempt to establish the incidence and type of neuropsychiatric disorders encountered. In 14 cases of PHPT, subjective or objective neuropsychiatric, or both, manifestations occurred. In four cases these signs dominated the clinical picture so that neurologic or psychiatric consultation was obtained before the diagnosis of PHPT had been established. Headache, muscle weakness, and mental changes were found to be prevalent and, in most instances, disappeared following parathyroid surgery. In general, neuropsychiatric signs correlated directly with the level... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 812-812KeywordsHeadachesHyperparathyroidismMusclesParathyroidSurgery Issue Published: 1 October 1964 PDF downloadLoading ...
Lithium and Metabolic Acidosis
Authors: JAMES W. JEFFERSON
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 March 1978Lithium and Metabolic AcidosisJAMES W. JEFFERSON, MD., F.A.C.P.JAMES W. JEFFERSON, MD., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-434_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The comprehensive article by Bennett, Plamp, and Porter on "Drug-Related Syndromes in Clinical Nephrology" (1) did not mention that lithium can produce a defect in urinary acidification. In both animals and man a decreased ability to lower urinary pH in response to acid loading has been shown (2-5). This defect has been described as a partial distal renal tubular acidosis with lithium-induced impairment of distal tubular hydrogen-ion secretion (5). Although high doses of lithium have produced a systemic acidosis in dogs (3), this has not been demonstrated in man. It is conceivable that lithium treatment might make...References1. BENNETT W, PLAMP C, and PORTER G: Drug-related syndromes in clinical nephrology. Ann Intern Med 87:582-590, 1977 LinkGoogle Scholar2. ROSCOE J, GOLDSTEIN M, HALPERIN M, WILSON D, and STINEBAUGH B: Lithium-induced impairment of urine acidification. Kidney Int 9:344-350, 1976 CrossrefMedlineGoogle Scholar3. NASCIMENTO L, RADEMACHER D, HAMBURGER R, ARRUDA J, and KURTZMAN N: On the mechanism of lithium-induced renal tubular acidosis. J Lab Clin Med 89:455-462, 1977 MedlineGoogle Scholar4. MILLER P, DUBOVSKY S, MCDONALD K, KATZ F, ROBERTSON G, and SCHRIER R: Central, adrenal and renal effects of lithium (Li) in man (abstract). Clin Res 25:98A, 1977 Google Scholar5. PEREZ G, OSTER J, and VAAMONDE C: Incomplete syndrome of renal tubular acidosis induced by lithium carbonate. J Lab Clin Med 86:386-394, 1975 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES W. JEFFERSON, MD., F.A.C.P.Affiliations: University of Wisconsin Center for Health Sciences Madison, WI 53706 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug Interactions and Drug Reactions 1 March 1978Volume 88, Issue 3Page: 434-434KeywordsAcidosisDrugsNephrology ePublished: 1 December 2008 Issue Published: 1 March 1978 PDF downloadLoading ...
Preliminary Iridectomy in Extraction of Cataract
Authors: F. H. Hodges
Journal: BMJ (1882)

It was thought that it would be safer and easier to remove the whole mass, which was accordingly done, rather than attempt removal of the tumour alone.The stump was secured by a wire clamp, and its serous outer surface was attacbed by silk to the abdominal wound.Two thick silk ligatures were also tied round the stump'for security.Very
Treatment of a capillary hemangioma with the flashlamp pumped-dye laser
Authors: K.A. Sherwood, O.T. Tan
Journal: Journal of the American Academy of Dermatology (1990)

An 11 week old baby boy had an infected hemangioma of the right fifth finger. Necrosis and a purulent discharge that cultured staphylococcus aureus developed distally. All treatments were performed with the SPTL 1 flash-lamp pumped dye laser
The associative nature of human associative learning
Authors: David R. Shanks
Journal: Behavioral and Brain Sciences (2009)

Abstract The extent to which human learning should be thought of in terms of elementary, automatic versus controlled, cognitive processes is unresolved after nearly a century of often fierce debate. Mitchell et al. provide a persuasive review of evidence against automatic, unconscious links. Indeed, unconscious processes seem to play a negligible role in any form of learning, not just in Pavlovian conditioning. But a modern connectionist framework, in which “cognitive” phenomena are emergent properties, is likely to offer a fuller account of human learning than the propositional framework Mitchell et al. propose.
The Clinical Spectrum of Light Chain Myeloma.
Authors: Marvin J. Stone
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972The Clinical Spectrum of Light Chain Myeloma.Marvin J. Stone, M.D., Eugene P. Frenkel, M.D., F.A.C.P.Marvin J. Stone, M.D.Search for more papers by this author, Eugene P. Frenkel, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-871_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLight chain disease is a common form of myeloma that is frequently difficult to recognize because of its variable clinical features and the absence of a monoclonal spike on routine serum protein electrophoresis. During the past 29 months 24 patients with light chain disease were seen; these constituted 25% of all the identified myeloma patients. The commonest initial manifestations were bone pain and progressive renal failure. Four patients had amyloidosis, and five others had plasmacytomas. One patient had no symptoms or signs referable to his plasma cell dyscrasia. Many of the anticipated features of classical myeloma were absent; thus, physician... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Marvin J. Stone, M.D.; Eugene P. Frenkel, M.D., F.A.C.P.Affiliations: Dallas, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 871-871KeywordsAmyloidosisBoneMyelomaPlasma cellsRenal failureSerum proteinsSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
The Influence of the U.S. Tobacco Industry on the Health, Economy, and Environment of Developing Countries
Authors: M Barry
Journal: New England Journal of Medicine (1991)

ALTHOUGH tobacco was first used in Central and South America in religious ceremonies, it was the arrival of Christopher Columbus in the New World and the subsequent exportation of tobacco to Europe that led to widespread smoking.1 Thus, there has been a long history of tobacco exportation from the Americas to overseas markets. The earliest antitobacco campaign was in 1604, when King James I imposed a tax on tobacco imported from the New World in an attempt to limit the "custome lothesome to the Eye, hatefull to the Nose, harmefull to the Braine, dangerous to the Lungs."2 Today, over $3.27 . . .
Ito cell heterogeneity: Desmin-negative ito cells in normal rat liver
Authors: Giorgio Ballardini, Paolo Groff, Lucilla Badiali de Giorgi, Detlef Schuppan, Francesco B. Bianchi
Journal: Hepatology (1994)

The presence of desmin is used to identify Ito cells in rat liver and to evaluate the purity of separated and cultured Ito cells. Heterogeneity of the normal Ito cell population has been suggested; this could include variations in the content of cytoskeletal components. For these reasons we decided to reevaluate the use of desmin staining as a phenotypical marker of Ito cells in normal rat liver. Our approach was to combine desmin staining with identification of vitamin A (autofluorescence), lipid droplets (Sudan III), vimentin, laminin and tenascin, using cryostat sections: Immunofluorescence, double-immunofluorescence or immunoperoxidase techniques were used. All the techniques described corroborate the existence of desmin-negative Ito cells, mainly located in pericentral areas. In fact, lobular desmin-positive cells showed uneven distribution because they were more frequent in periportal than in pericentral areas. On the contrary, Ito cells identified on the basis of morphological criteria or positivity for laminin were evenly distributed. Double immunofluorescence confirmed this observation, showing nearly complete codistribution of laminin and desmin in periportal areas. Outside this area, positivity for desmin was observed only in about 50 of lamininpositive cells. Our observations suggest that desmin cannot be viewed as a phenotypical marker but rather is a differentiation marker of Ito cells, possibly indicating a specific functional state. (Hepatology 1994;19:440-446).
Stem Cell Therapy in Kidney Transplantation—Reply
Authors: Jianming Tan, Antonello Pileggi, Camillo Ricordi
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of flat lesions in a large screening population and their role in colonoscopy quality improvement
Authors: Han-Mo Chiu, Silvia Sanduleanu, Tonya Kaltenbach, Roy Soetikno
Journal: Endoscopy (2013)

We read with great interest the article by Reinhart et al. [1], who evaluated the prevalence and significance of flat lesions in a nationwide screening program in Austria. Indeed, the monitoring of colonoscopy findings and its quality at a national level is vital for developing strategies to improve the effectiveness of a screening service. In a retrospective analysis of 52 521 participants who underwent colonoscopy between 2007 and 2011, the authors found that polyp size rather than polyp shape was the strongest predictor for advanced histology, thus discouraging the inclusion of flat polyp detection rates as a quality indicator of screening colonoscopy.
Changing character of cervical cancer in young women.
Authors: P. M. Elliott, M. H. Tattersall, M. Coppleson, P. Russell, A. S. Coates, H. J. Solomon
Journal: BMJ (1989)

To examine the hypothesis that the pattern of cervical cancer is changing data on women presenting with the disease over 34 years were studied retrospectively. During 1953-86, 2628 women with cervical cancer were referred to a large tertiary referral hospital in Sydney; 418 were aged 35 or less. During the period of review the proportion of young women with the disease increased from under 9% in the 1950s and 1960s to about 25% in the 1970s and 1980s; a similar but less pronounced trend was apparent for the whole of New South Wales in the 1970s and 1980s. The prevalence of less common morphological types of cervical cancer increased throughout the period, particularly in the young. Pelvic lymph node metastases were identified in younger patients with stage Ib and IIa tumours more commonly in the later years of the study, suggesting that the disease was becoming more severe. Overall rates of recurrence improved over time, but an apparent increase in early recurrences was observed in young patients with Ib and IIa tumours and without nodal disease. The results suggest that the clinical and pathological behaviour of cervical cancer changed over the period of review.
High-Risk Surgery—Follow the Crowd
Authors: John D. Birkmeyer
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human and animal health: strengthening the link: Authors' reply to methodological concerns
Authors: Christian Antonioli, Michael Reveley
Journal: BMJ (2005)

Methodological concerns about animal facilitated therapy with dolphinsEditor-We have the following concerns with Antonioli and Reveley's study of animal facilitated depression with dolphins in the treatment of depression. 1 The study was small (30 patients), only 13 people from the animal care programme and 12 from the outdoor nature programme completing the study.The authors used a conservative measure to estimate the number of patients required for this study, and even then fell short by 17%.Single women predominated in both arms.It is difficult to fathom how clinical raters can be blinded to the treatment hypothesis.The authors did not mention the ethnic group of the participants.Only people who could go to Honduras were able to take part in this study.Most people with mild depression will not be able to take a three week holiday.The findings are not generalisable as most people would not be able to afford to go to such a location and swimming and snorkeling are not necessarily favourite pastimes.There may be a vacation bias.If the study group sponsored the three week trip to Honduras we suspect that a free three week trip to a seaside location in Latin America would in itself be a powerful antidepressant.There may be a disappointment bias.If the control group were aware of the potential to be in a group where they could interact with dolphins for two weeks before they reached Honduras, they could be disappointed in missing out.People with depression perceive disappointment more intensely.The study could have been done in a more natural and plausible setting with common pets such as dogs or cats for a fraction of the cost.