tbuckley/cabot-search huggingface dataset:
PWE-180 Clinical and laboratory characteristics and the use of biodegradable stents in eosinophilic oesophagitis: a single centre UK experience
Authors: R Rameshshanker, P Patel, M Moorghen, M Pitcher
Journal: Gut (2012)

<h3>Introduction</h3> Eosinophilic Oesophagitis (EoE) is an under recognised condition. There are clues in the history, biochemistry, immunology and gastroscopy to make the diagnosis. Strictures associated with this condition need careful endoscopic management. <h3>Methods</h3> Retrospective review of histology proven eosinophilic oesophagitis cases between April 2009 and June 2011. <h3>Results</h3> Total no of patients 16, Male: female=7:1. Age range: 18–89 years (IQR 24.25 (24.75–49). Mean age 41.5 years. All of them complained of intermittent dysphagia and 50% of them had a history of food bolus impaction on presentation. Only 25% had symptoms less than a year. 18.75% (3/16) had symptoms for more than 10 years.10/16 (62.5%) had a history of atopy. 2/16 (12.5%) had food intolerance/oral allergy especially for fruits. 6/16 had oesophageal manometry; 5/6 of them had normal manometry findings and one showed dysmotility. 50% had barium swallow; two of them showed mild dysmotility. 7/16 had high peripheral eosinophil count (0.04–0.4). Mean 0.58. Only 56% (9/16) of patients had IgE levels checked, 8/9 had high IgE levels. All of them were treated with proton pump inhibitors, while 75% needed fluticasone inhaler. 25% needed montelukast maintenance therapy to achieve clinical benefit. 25% showed normal gastroscopy, remainder showed characteristic findings such as concencentric rings, furrows with ulceration. 25% had symptomatic oesophageal strictures; two of them had balloon dilatation previously. The other 2 (50%) were successfully treated with biodegradable stent. One patient had sustained response with single stent even after 18 months, the other had two sequential stents (8 months apart) to improve the symptom of dysphagia. <h3>Conclusion</h3> To diagnose the condition history is crucial, while laboratory and gastroscopy add more strength. Fluticasone inhaler, exclusion diets and montelukast help in the majority of patients. Strictures associated with EoE can be successfully treated with biodegradable stent. <h3>Competing interests</h3> None declared.
Prognostic factors and early predictability of sustained viral response with peginterferon alfa-2a (40KD)
Authors: Samuel S Lee, E.Jenny Heathcote, K.Rajender Reddy, Stefan Zeuzem, Michael W Fried, Teresa L Wright, Paul J Pockros, Dieter Häussinger, Coleman I Smith, Amy Lin, Stephen C Pappas
Journal: Journal of Hepatology (2002)
Non-amyloidogenic peptide tags for the regulatable self-assembling of protein-only nanoparticles
Authors: Ugutz Unzueta, Neus Ferrer-Miralles, Juan Cedano, Xu Zikung, Mireia Pesarrodona, Paolo Saccardo, Elena García-Fruitós, Joan Domingo-Espín, Pradeep Kumar, Kailash C. Gupta, Ramón Mangues, Antonio Villaverde, Esther Vazquez
Journal: Biomaterials (2012)
Sexual Medicine and Counseling in Office Practice: A Comprehensive Treatment Guide
Authors: Domeena C. Renshaw
Journal: JAMA (1981)

This 466-page handbook assists physicians in practice in dealing with the everyday sexual problems of able-bodied persons as well as those in whom illness and medication affect the sexual responses. The self-administered screening questionnaire is thorough and thought provoking for the patient. It is a time-saver and may reveal antecedent factors relating to current sex problems. The physician is encouraged by the authors to proceed by selecting main problems from the questionnaire to be followed by a face-to-face problem-oriented history (pp 20 to 23). Some essential and relevant questions were omitted, however, and might be appended as follows: (p 21) II D. Sex play with relatives? Whom? What ages? How often? Did you tell anyone? Whom? Was there pain/fear/excitement/pleasure/orgasm/intercourse/other? Q. What was your body image like as a child/teen/now? P. Sickness? Age? What? Did this affect your body image? Q. Surgery? Age? What? Did this affect your body image? (p
Pneumoarthropathy in septic arthritis caused by Streptococcus milleri.
Authors: A M Lever, T Owen, J Forsey
Journal: BMJ (1982)

and 2-3 per 15 minutes respectively).Swallowing was significantly more frequent in patients with hiatus hernia and in those with duodenal ulcer than in either control group (13-2 and 9-8 per 15 minutes) (p<00005).There was no correlation between swallow count and age, sex, salivary output, or anxiety as measured by either skin conductance or the self-report questionnaires.
807-2 Selective inhibition of human cardiac Kir2.2 inward rectifier channels by adrenergic alpha-1a receptors
Authors: Edgar Zitron, Claudia Kiesecker, Sonja Lück, Eberhard Scholz, Dierk Thomas, Sven Kathöfer, Volker A.W Kreye, Wolfgang Schoels, Hugo A Katus, Christoph A Karle
Journal: Journal of the American College of Cardiology (2004)
1014-95 Comparative Effect of Inotropic Agents on Oxygen Expenditure Between β -Stimulation, Phospho-Diesterase Inhibition and Ca 2+ Sensitization
Authors: Hideyuki Takaoka, Motoshi Takeuchi, Katsuya Hata, Masuki Mori, Hideyuki Yamakawa, Kozo Yamaguchi, Mitsuhiro Yokoyama
Journal: Journal of the American College of Cardiology (1995)
Adult and Pediatric Urology
Authors: Alan H. Bennett
Journal: JAMA (1991)

In 1970, during my chief residency year, the late J. Hartwell Harrison asked me to review the three-volume third edition of Campbell and Harrison's<i>Urology</i>and write a final chapter entitled "Controversy and Perspective in Urology."<sup>1</sup>I certainly did not predict all of the important changes that have occurred in our specialty in the past two decades—endoscopic and extracorporeal lithotripsy, continent urinary diversion, the whole new specialty of impotence evaluation and management, to mention just a few. However, the exercise was certainly worthwhile, not the least in helping to prepare for the American Board of Urology examination! <i>Adult and Pediatric Urology</i>is a new undertaking with a different editorial complement than the last (fifth) edition of<i>Campbell's Urology</i>published in 1986. In keeping with the tradition established by Meredith Campbell, I have asked my current residents to critique<i>Adult and Pediatric Urology</i>"from the modern perspective of a urologic
793. Induction of Molecular Chimerism in NOD Mice Is Resistant to the Occurrence of Type I Diabetes Induced by Blockade of the Programmed Death-1 Pathway
Authors: Chaorui Tian, Jessamyn Bagley, Mohammed Javeed I. Ansari, Mohamed Sayegh, John Iacomini
Journal: Molecular Therapy (2006)

Introduction: We have recently shown that induction of molecular chimerism by reconstitution of NOD mice with autologous bone marrow cells reconstituted with retrovirus carrying genes encoding MHC class II β chains (either IAβd or IAβk) from protective haplotypes can induce central deletion of auto-reactive T cells and prevent occurrence of type 1 diabetes (T1D) in NOD mice. Studies have also shown that blockade of programmed death (PD-1) pathway using anti-PD-L1 monoclonal antibody results in precipitated occurrence of T1D in naïve NOD mice. Here we show that induction of molecular chimerism in NOD mice is resistant to the occurrence of T1D induced by anti-PD-L1 antibody treatment. Methods: Bone marrow cells were harvested from 4-week old NOD mice treated with 5-fluorouracil (150mg/kg) 7 days prior and then transduced with retrovirus carrying genes encoding either a protective MHC class II β chain or GFP alone as a control. 4 weeks old recipient NOD mice were lethally irradiated and reconstituted the following day with either IAβd-GFP or GFP transduced bone marrow. 4 weeks after reconstitution, recipient mice were treated with anti-PD-L1 monoclonal antibody or rat IgG as a control. Results: 75% of the mice reconstituted with control GFP transduced bone marrow and treated with anti-PD-L1 antibody developed diabetes by 85 days after antibody treatment (Median onset time (MOT) = 32 days), while 67% of the mice reconstituted with control GFP transduced bone marrow and treated with control rat IgG developed diabetes by 134 days (MOT = 129 days, p<0.001), suggesting that anti-PD-L1 treatment precipitates the occurrence of T1D in NOD mice reconstituted with control GFP transduced bone marrow. In contrast, all the mice that reconstituted with IAβd-GFP transduced bone marrow and treated with control rat IgG remained normoglycemic 180 days after reconstitution at which time point our experiments terminated. Only 1 out of 12 mice reconstituted with IAβd-GFP transduced bone marrow and treated with anti-PD-L1 treatment developed diabetes. Conclusion: Induction of molecular chimerism in NOD mice is resistant to the occurrence of T1D induced by anti-PD-L1 treatment.
Left Atrial Appendage Occlusion — Closure or Just the Beginning?
Authors: William H. Maisel
Journal: New England Journal of Medicine (2009)

More than 3 million Americans have atrial fibrillation, which increases their risk of stroke by a factor of 5.1,2 Patients with atrial fibrillation account for one of every six strokes, and thromboemboli originating from the left atrial appendage are the suspected culprit in the vast majority of these cases.1,2 Warfarin, a vitamin K antagonist, is the most commonly prescribed treatment for stroke prevention in patients with atrial fibrillation; yet despite warfarin's proven benefit, its effective delivery is challenged by a narrow therapeutic window and an increased risk of bleeding. Efforts have been made to develop alternative treatment strategies . . .
THE VALUE OF DIFFERENTIAL DIAGNOSIS IN DENTISTRY.
Authors: V. A. LATHAM
Journal: JAMA (1896)

The subject of diagnosis is one of much importance to a practitioner, and the man who can diagnose rapidly and correctly is usually successful in his profession. In medical works great importance is laid on diagnosis even to such a degree that special works are written on the subject. Who does not remember the differential tables in nervous, respiratory and cardiac diseases, and the dread they inspired at examinations? Without their aid we are not able to diagnose our cases, and hence the urgency of requiring students to learn them. I have constantly been surprised at the difficulties which students encounter in dental surgery and pathology. Even a well-read student finds it hard to bring his knowledge to bear promptly and efficiently upon the patient before him. The recognition of the several symptoms which the student has learned from lectures or reading can be best directed by the teacher at
Insulin Allergy: Differences in the Binding of Porcine, Bovine, and Human Insulins with Anti-Insulin IgE
Authors: Dinesh Kumar
Journal: Diabetes Care (1981)

We investigated in vitro binding of insulins of various species sources (bovine, porcine, and human) with anti-insulin reaginic immunoglobulins (IgE) in 10 patients with systemic insulin allergy and in 5 nonallergic but insulin-resistant cases. Anti-insulin IgE had a higher avidity for bovine compared with porcine insulin in both groups. Avidity for bovine insulin was also significantly higher compared with human or desalanine porcine insulin in the insulin-allergic patients. These observations provide a rationale for using porcine insulin in the treatment of systemic insulin allergy.
Allergic Granulomas of the Prostate in Asthmatics
Authors: Panayotis P. Kelalis, Edgar G. Harrison, Laurence F. Greene
Journal: JAMA (1964)

Five cases of allergic granuloma of the prostate occurring exclusively in asthmatic patients have been reported in detail. The lesions are characterized histologically by areas of fibrinoid necrosis within histiocytic granulomas with an intense eosinophilic infiltration. The cause is unknown, although the condition is considered to be the result of a hypersensitivity reaction. Symptoms are those of vesical neck irritation and rapidly progressive lower urinary tract obstruction, which is corrected by transurethral resection. Marked eosinophilia may be present. Similar allergic granulomas and necrotizing vasculitis (allergic granulomatosis variant of periarteritis nodosa) were found in the lungs of one of the patients who died. Prompt recognition and early steroid therapy may be of value in the management of future cases.
Towy Owen Watkin Myrddin-Evans
Authors: Gail Murray
Journal: BMJ (2006)

​FormerFormer general practitioner London (b 1920; q Oxford/St Mary's Hospital, London, 1948; MRCGP), d 9 April 2006.



Figure 1



Towy Myrddin-Evans was noted for his quarter and half mile sprints at school and obtained his blue at Oxford. He undertook national service in the Royal Navy, serving as a medical officer on HMS Glasgow, Victory, and Vanguard, as well as being fleet medical officer to the Home Fleet. He took up practice as a private general practitioner in the Medical Suite, Grosvenor House, London, becoming senior partner, until retiring in 1985. He was also medical adviser to several companies, including Arco Oil, Aramco Overseas, Chicago Bridge, Henlys, and Texaco. Predeceased by his wife, Tomina, in 2000, he leaves two daughters.
Funding medicines for people with multiple sclerosis
Authors: D. Taylor
Journal: BMJ (2001)

The establishment of the National Institute for Clinical Excellence (NICE) in 1999 was one of the cornerstones of New Labour's strategy for improving the NHS. Its mission includes giving guidance on how medicines should be prescribed to provide affordable value for money. This should eliminate postcode rationing, whereby some NHS patients are given expensive drugs depending on where they live, while people with similar needs elsewhere are denied the same treatment.

Recommendations from NICE have often levelled up access to pharmaceutical care. But a recent decision by NICE not to support the use of interferon beta in multiple sclerosis has become a focus of critical attention. Patient support groups and pharmaceutical companies argue that this will undesirably lower standards of NHS care. There are also concerns among pharmaceutical companies that where Britain leads in restricting access to new drugs others may follow. The waters have also been muddied by news that Britain's Department of Health is negotiating with manufacturers of interferon beta to find a way of funding the drug for patients with multiple sclerosis on a “sale or return” basis.1

When, last month, NICE published its “final appraisal …
Reduced transport of bilirubin and asialoorosomucoid in regenerating rat liver is a microtubule-independent event
Authors: Yacov R. Stollman, Lorenz Theilmann, Richard J. Stockert, Allan W. Wolkoff
Journal: Hepatology (1985)

In previous studies, we found that uptake of bilirubin and asialoorosomucoid is depressed in regenerating rat liver. To determine what role the hepatic cytoskeleton plays in this modulation of uptake, animals were treated with colchicine, an inhibitor of microtubular polymerization. Normal unoperated rats or rats following two–thirds hepatectomy or sham surgery were injected with colchicine, lumicolchicine (50 μg per 100 gm of body weight, i.p.) or normal saline. Lumicolchicine, an analog of colchicine, has no effect on microtubules and was used as a control. At 12 hr after surgery, sham–operated and unoperated animals received a second equal dose. Partially hepatectomized animals received one–third the initial dose. At 24 hr after surgery, livers were perfused in situ and single–pass multiple indicator dilution studies were performed. Colchicine as compared to lumicolchicine pretreatment reduced apparent influx of bilirubin and asialoorosomucoid in regenerating liver by 50% but had no effect in liver from normal or sham–operated rats. Analysis of indicator dilution curves revealed that reduced influx in colchicine–treated liver was attributable to an increased vascular volume of distribution. These results suggest that microtubules may play a role in maintenance of normal hepatic vascular architecture during regeneration. Lack of effect of colchicine on modulation of bilirubin and asialoorosomucoid uptake during regeneration suggests that other, as yet unknown, factors result in down–regulation of the specific hepatocellular transport systems for these two ligands.
Treatment of atopic eczema in children: clinical trial of 10% sodium cromoglycate ointment.
Authors: S A Haider
Journal: BMJ (1977)

In a double-blind randomised group-comparative trial 21 children with chronic atopic eczema were treated twice daily for up to 12 weeks with an ointment containing 10% sodium cromoglycate (SCG) in white soft paraffin. A similar group of 21 children was treated for up to 12 weeks with a placebo ointment consisting of the white soft-paraffin base only. The number of patients who withdrew from the trial because treatment was ineffective was significantly greater in the placebo group (16) than in the SCG group (four). Comparison between the two groups also showed significant improvement in inflammation, lichenification, and cracking and the symptoms of itching and sleep disturbance among those on SCG treatment. At the end of treatment significantly more patients in the SCG group (16) had benefited from treatment compared with only two patients in the placebo group. No patients experienced side effects. I conclude that SCG ointment may be a safe alternative to topical steroids in the treatment of atopic eczema in children.
The concentrations of arsenic and other toxic elements in Bangladesh's drinking water.
Authors: Seth H Frisbie, Richard Ortega, Donald M Maynard, Bibudhendra Sarkar
Journal: Environmental Health Perspectives (2002)

For drinking water, the people of Bangladesh used to rely on surface water, which was often contaminated with bacteria causing diarrhea, cholera, typhoid, and other life-threatening diseases. To reduce the incidences of these diseases, millions of tubewells were installed in Bangladesh since independence in 1971. This recent transition from surface water to groundwater has significantly reduced deaths from waterborne pathogens; however, new evidence suggests disease and death from arsenic (As) and other toxic elements in groundwater are affecting large areas of Bangladesh. In this evaluation, the areal and vertical distribution of As and 29 other inorganic chemicals in groundwater were determined throughout Bangladesh. This study of 30 analytes per sample and 112 samples suggests that the most significant health risk from drinking Bangladesh's tubewell water is chronic As poisoning. The As concentration ranged from < 0.0007 to 0.64 mg/L, with 48% of samples above the 0.01 mg/L World Health Organization drinking water guideline. Furthermore, this study reveals unsafe levels of manganese (Mn), lead (Pb), nickel (Ni), and chromium (Cr). Our survey also suggests that groundwater with unsafe levels of As, Mn, Pb, Ni, and Cr may extend beyond Bangladesh's border into the four adjacent and densely populated states in India. In addition to the health risks from individual toxins, possible multimetal synergistic and inhibitory effects are discussed. Antimony was detected in 98% of the samples from this study and magnifies the toxic effects of As. In contrast, Se and Zn were below our detection limits in large parts of Bangladesh and prevent the toxic effects of As.
Intrathoracic chemodectoma with noradrenaline secretion.
Authors: B K Nigam, S L Hyer, E J Taylor, T Guha
Journal: Thorax (1981)

Tumours arising in the chemoreceptor system are termed chemodectomas.Intrathoracic chemodectoma is a rare tumour, only 74 cases having been described by 1977.1 Systemic catecholamine secretion by an intrathoracic chemodectoma is very uncommon and- we have been able to trace only one other published case report of proven catecholamine secretion.We describe a second case and discuss briefly these interesting tumours. Case reportA 38-year-old housewife was referred to the cardiac unit for investigation of hypertension which had on July 10,
Intérêt de la mise en place simultanée de 3 prothèses biliaires dans le traitement endoscopique des sténoses anastomotiques biliaires post transplantation hépatique
Authors: D Karsenti, A Charachon, A Laurent, C Tayar, M Karoui, J Loriau, M Hurtova Simson, T Decaens, C Duvoux, C Hezode, JC Delchier, D Cherqui
Journal: Endoscopy (2008)

Introduction: La prise en charge endoscopique des sténoses anastomotiques biliaires post transplantation hépatique (TH) impose habituellement une période de calibration de plus d'un an, impliquant de nombreuses CPRE. Le but de cette étude était d'évaluer la morbidité et l'efficacité (succès et durée de calibration) d'un traitement endoscopique «agressif» consistant à mettre en place simultanément 3 prothèses biliaires après une dilatation à fort diamètre de l'anastomose.
GENERAL PARALYSIS OF THE INSANE DURING SENESCENCE
Authors: Ira A. Darling
Journal: American Journal of Psychiatry (1925)

1. The differential diagnosis of general paralysis of the insane and psychoses with arterio-sclerosis or somatic diseases may be difficult and depend to a great extent upon laboratory examinations of the spinal fluid. 2. General paralysis of the insane is frequently the cause of the first admission to hospitals of patients 60 or more years old; in this series 8 per cent of all admissions due to the disease. 3. The cases studied in this report indicate that the period of incubation, duration of mental symptoms, and prognosis for periods of improvement is about the same with these old people as for the general average of the disease.
Visual Disturbances Experienced by Hallucinogenic Drug Abusers While Driving
Authors: GEORGE E. WOODY
Journal: American Journal of Psychiatry (1970)

The author presents three case reports of young men with histories of hallucinogen usage who experienced visual disturbances while driving. None was "high" at the time of the experience. It is likely that the disturbances were due to recurrences of the acute effects of one or more hallucinogens. The author believes that use of these drugs may be introducing a new driving hazard.
Homonymous Hemianopsia? Does Confrontation Get You Down?
Authors: George W. King
Journal: JAMA (1976)

ABSTRACT To the Editor.— In the gross evaluation of visual fields done as part of the neurological examination, you have been taught to face the patient, each of you with one eye covered, to compare his peripheral vision with your own. You ask him to tell you when he can see your finger zeroing in from the side, but this makes him dart a glance in its direction so that you are never sure what part of the field he is using, peripheral or foveal.Now comes a new wrinkle in this old test in which the doctor confronts the patient in the same manner, but holding the index finger of each hand out to each side at 180 degrees. By asking the patient to tell which finger is wiggling, you can accurately tell a defect in the peripheral fields. The patient's gaze is fixed in the center, on your own