Pulse Methotrexate Therapy in Rheumatoid Arthritis
Authors: A. M. TH. BOERBOOMS
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Pulse Methotrexate Therapy in Rheumatoid ArthritisA. M. TH. BOERBOOMS, M.D., Ph.D., M. E. C. JEURISSEN, M.D., L. B. A. VAN DE PUTTE, M.D., Ph.D.A. M. TH. BOERBOOMS, M.D., Ph.D.Search for more papers by this author, M. E. C. JEURISSEN, M.D.Search for more papers by this author, L. B. A. VAN DE PUTTE, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-905_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the report of Nordstrom and coworkers (1) on radiographic progression in 18 patients with refractory rheumatoid arthritis treated with low-dose methotrexate in a prospective open study. Each patient had three sets of hand, wrist, and foot radiographs: the first set within an average of 33 months before methotrexate therapy, the second at the start of therapy, and the third at an average of 30 months after the start of therapy. Methotrexate may not be a disease-modifying drug because the two rates of radiologic progression before and during therapy were not significantly different.This result...References1. NORDSTROMWESTANDERSENSHARP DSPJ. Pulse methotrexate therapy in rheumatoid arthritis. A controlled prospective roentgenographic study. Ann Intern Med. 1987;107:797-801. LinkGoogle Scholar2. KREMERLEE JJ. The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis. Arthritis Rheum. 1986;29:822-31. CrossrefMedlineGoogle Scholar3. IANUZZIDANSONZEINKUSHNER LNNI. Does drug therapy slow radiographic deterioration in rheumatoid arthritis? N Engl J Med. 1983;309:1023-8. CrossrefMedlineGoogle Scholar4. SIGLERBLUHMDUNCANSHARPENSIGNMCCRUM JGHJDW. Gold salts in the treatment of rheumatoid arthritis: a double blind study. Ann Intern Med. 1974;80:21-6. LinkGoogle Scholar5. BOERBOOMSWESTGEESTJEURISSENTHEUNISEVAN DE PUTTE AAMHL. Methotrexate: effects in patients with rheumatoid arthritis, refractory on hydrochloroquine, aurothioglucose, D-penicillamineand azathioprine. Influence on the immunoglobulins [Abstract]. XIth European Congress of Rheumatism. Athens, 28th June-4th July 1987. Abstract P544. Google Scholar1. KREMERLEE JJ. The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis. Arthritis Rheum. 1986;29:822-31. CrossrefMedlineGoogle Scholar2. ANDERSENWESTO'DELLVIACLAYPOOLKOTZIN PSJCRB. Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study. Ann Intern Med. 1985;103:489-96. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Hospital Nijmegen Nijmegen the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMethotrexate in Rheumatoid Arthritis Feedback on American College of Physicians GuidelinesPeter Tugwell, MD, Kathryn Bennett, MSc, Mary Bell, MD, Michael Gent, MD 1 June 1988Volume 108, Issue 6Page: 905-905KeywordsDrug therapyHeart rateMethotrexateProspective studiesRheumatoid arthritis Issue Published: 1 June 1988 PDF DownloadLoading ...