Leukemia with Osteoarticular Symptoms and Signs
Authors: MURRAY N. SILVERSTEIN
Journal: Annals of Internal Medicine (1963)

Article1 November 1963Leukemia with Osteoarticular Symptoms and SignsMURRAY N. SILVERSTEIN, M.D., PATRICK J. KELLY, M.D.MURRAY N. SILVERSTEIN, M.D.Search for more papers by this author, PATRICK J. KELLY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-5-637 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLeukemic involvement of bone and joints has been recognized from the time of Virchow (1). If bone and joint involvement predominates in acute leukemia when first seen, considerable diagnostic confusion may arise. In several reported cases, acute leukemia closely mimicked rheumatic fever (2-7). The purpose of this presentation is to review a group of cases of acute leukemia in which the clinical course was dominated by bone and joint symptoms.METHODS AND MATERIALSFrom two 3-year periods taken at random (1945 to 1947 and 1955 to 1957), the records of all Mayo Clinic cases diagnosed as acute leukemia were reviewed....References1. VIRCHOW R: White blood. In Classic Descriptions of Disease, With Biographical Sketches of the Authors, by R. H. Major, 3rd ed., Charles C Thomas, Publisher, Springfield, Illnois, 1945, p. 510. Google Scholar2. AISNERHOXIE MTB: Bone and joint pain in leukemia, simulating acute rheumatic fever and subacute bacterial endocarditis. New Eng. J. Med. 238: 733, 1948. CrossrefMedlineGoogle Scholar3. BALDRIDGEAWE CWCD: Lymphoma: a study of one hundred and fifty cases. Arch. Intern. Med. 45: 161, 1930. CrossrefGoogle Scholar4. DEBRÉMILHITLAMYFOUQUET RJMJ: Leucoses et leucemies aiguës de l'enfance. Bull. Soc. Méd. Hôp. Paris. 1: 657, 1939. Google Scholar5. ERLICHFORER JCS: Periosteal ossification in myelogenous leukemia: report of a case associated with acute rheumatic fever. Arch. Intern. Med. 53: 938, 1934. CrossrefGoogle Scholar6. POYNTONLIGHTWOOD FJR: Lymphatic leukemia, with infiltration of periosteum simulating acute rheumatism. Lancet 1: 1192, 1932. CrossrefGoogle Scholar7. SEWARD BP: Lymphatic leucemia with severe pain in the joints. Med. J. Rec. 131: 444, 1930. Google Scholar8. THOMASFORKNERFREIBESSESTABENAU LBCEEBEJR: The skeletal lesions of acute leukemia. Cancer 14: 608, 1961. CrossrefMedlineGoogle Scholar9. STRAUCH A: Acute lymphatic leukemia in early life. Amer. J. Dis. Child. 5: 43, 1913. Google Scholar10. POYNTONTHURSFIELDPATERSON FJHD: The severe blood diseases of childhood: a series of observations from the hospital for Sick Children, Great Ormond Street. Brit. J. Child. Dis. 19: 128, 1922. Google Scholar11. REUBEN SM: Differential diagnosis of diseases of the hematopoietic system. Arch. Pediat. 43: 15, 1926. Google Scholar12. WOLLSTEIN M: Leukemia in young children (abstract). Amer. J. Dis. Child. 44: 661, 1932. Google Scholar13. COOKE JV: Acute leukemia in children. JAMA 101: 432, 1933. CrossrefGoogle Scholar14. CASAUBONCOSSAY AS: Analisis de diez casos de leucemia linfática en la infancia. Sem. Med. 1: 1185, 1937. Google Scholar15. FALKENSTEINFOWLER DWM: Acute lymphatic leukemia in childhood. Amer. J. Dis. Child. 65: 445, 1943. Google Scholar16. BICHEL J: Arthralgic leukemia in children. Acta Haemat. 1: 153, 1948. CrossrefMedlineGoogle Scholar17. EPSTEIN BS: Vertebral changes in childhood leukemia. Radiology 68: 65, 1957. CrossrefMedlineGoogle Scholar18. HILBISHBESSELUSTEDDANESTHOMASFARKNER TFBELBMLLBCE: Acute leukemia: skeletal manifestations in children and adults. Arch. Intern. Med. 104: 741, 1959. CrossrefMedlineGoogle Scholar19. SILVERMAN FN: The skeletal lesions in leukemia: clinical and roentgenographic observations in 103 infants and children, with a review of the literature. Amer. J. Roentgen. 59: 819, 1948. Google Scholar20. WILLSON JK: The bone lesions of childhood leukemia: a survey of 140 cases. Radiology 72: 672, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, MinnestotaFrom the Mayo Clinic and Mayo Foundation, Rochester, Minnesota.Requests for reprints should be addressed to Mayo Clinic, Rochester, Minnesota. 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NIES, M.D., DONALD W. KUNDEL, M.D., LOUIS B. THOMAS, M.D., EMIL J FREIREICH, M.D.Bone Manifestations of Hematologic Disorders 1 November 1963Volume 59, Issue 5_Part_1Page: 637-645KeywordsAnemiaBoneRheumatic feverSigns and symptoms Issue Published: 1 November 1963 PDF downloadLoading ...