tbuckley/cabot-search huggingface dataset:
Psychotherapy with Comatose Patients
Authors: Liliana Chamó
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Psychotherapy with Comatose Patients Subject Area: Psychiatry and Psychology Liliana Chamó Liliana Chamó Asociación Argentina de Psicoterapia Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 7–12. https://doi.org/10.1159/000286822 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Liliana Chamó; Psychotherapy with Comatose Patients. Psychother Psychosom 31 December 1975; 25 (1-6): 7–12. https://doi.org/10.1159/000286822 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Abstract 3402: Knockdown of TWIST1 increases chemosensitivity of osteosarcoma cells
Authors: Gufeng Xu, Jianhe Shen, Alex Yu, Hongmei Wang, Tsz Kwong Man, Ching C. Lau
Journal: Cancer Research (2010)

Abstract Knock-down of TWIST1 increases chemosensitivity of osteosarcoma cells Texas Children's Cancer Center; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 TWIST1, a basic helix-loop-helix (bHLH) transcription factor, has previously been reported to be involved in cancer metastasis, invasion, drug response, and osteoblast differentiation induced by bone morphogenic protein. Based on expression profiling, we have previously identified a chemoresistance signature in osteosarcoma that could predict at the time of diagnosis the response to neoadjuvant chemotherapy. One of the 45 genes in the chemoresistance signature is TWIST1 whose expression level was significantly higher in osteosarcomas that were subsequently found to be more chemoresistant. To investigate the involvement of TWIST1 in chemoresistance of osteosarcoma at the cellular level, we first demonstrated that the IC50 of doxorubicin but not cisplatin treatment in eight osteosarcoma cell lines correlated with the endogenous TWIST1 expression level. We then tested the hypothesis that down-regulation of TWIST1 expression through RNAi in osteosarcoma cell lines with high TWIST1 expression could restore the chemosensitivity in these cells. Using two independent shRNAs to knock-down TWIST1 in HOS, SJSA-1 or 143B cells, we were able to show that the transduced cells became more sensitive to doxorubicin treatment as compared with the parental cells or control cells that were transduced with shRNAs with scrambled sequences. The results of the cytotoxicity assay were confirmed by the clonogenic assay using single colonies of stable transfectants with HOS cells. Based on these results, we concluded that TWIST1 is involved in chemoresistance of osteosarcoma cell lines and that down-regulation of its expression through RNAi would sensitize osteosarcoma cells to doxorubicin. However, we did not observe increased chemoresistance with overexpression of TWIST1 in osteosarcoma cell lines that have low levels of TWIST1 expression, suggesting that TWIST1 alone is not sufficient to cause chemoresistance in osteosarcoma cells. Identification of downstream targets of TWIST1 that could mediate chemoresistance by comparing expression profiles of TWIST1-knockdown clones with parental and scrambled controls is ongoing. In summary, these results validate our previous finding that TWIST1 can be used as a potential marker for predicting chemoresistance in osteosarcoma and suggest that modulating TWIST1 or its downstream targets could be considered as a novel strategy to overcome chemoresistance in osteosarcoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3402.
Advances in Gross Anatomy in the 20th Century
Authors: Edward A. Edwards
Journal: JAMA (1977)

"The structure of the body hasn't changed much since Vesalius, has it?" "No, neither has the atomic nucleus." Attributed to Lactantius THE RECENT reprinting of the first (1901)<i>Gray's Anatomy</i>of the century<sup>1</sup>has prompted a consideration of what advances gross anatomy has made in the first three quarters of this century. At first glance, the 1901<i>Gray's Anatomy</i>seems very similar to a current text. What has been added since 1901 are structures of small dimension, but with great physiologic impact. This communication will concern itself with gross anatomy, referring briefly to the findings of microscopy or physiology where these add substantially to the consideration of gross structures. This is in keeping with the traditional reliance of anatomists on those disciplines to add meaning to the disclosures of dissection. <h3>CARDIAC CONDUCTION SYSTEM</h3> When we examine the 1901 edition of Gray and compare it with present day knowledge, the
Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors
Authors: Yusuke Oe, R. James Christie, Mitsuru Naito, Stewart A. Low, Shigeto Fukushima, Kazuko Toh, Yutaka Miura, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
Journal: Biomaterials (2014)
OBSERVATIONS ON THE USE OF AMMI MAJUS LINN. IN VITILIGO
Authors: ABDEL-MONEIM EL-MOFTY
Journal: British Journal of Dermatology (1952)

Journal Article OBSERVATIONS ON THE USE OF AMMI MAJUS LINN. IN VITILIGO Get access ABDEL‐MONEIM EL‐MOFTY, M.D. ABDEL‐MONEIM EL‐MOFTY, M.D. Assistant Professor of Dermatology, Kasr‐El‐Aini Faculty of Medicine, Cairo Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 64, Issue 12, 1 December 1952, Pages 431–441, https://doi.org/10.1111/j.1365-2133.1952.tb15880.x Published: 01 December 1952
Swallowable capsule technology: current perspectives and future directions
Authors: K. Twomey, J. Marchesi
Journal: Endoscopy (2009)

The mammalian gut is a complex ecosystem, which is colonized by a diverse collection of microbes [1]. For many years this ecosystem has been treated as a black box. Firstly, it is very difficult to obtain accurate data on what is happening throughout the intestinal tract, and secondly, many of the bacteria in the gut cannot be cultured in vitro. Whereas the latter issue is a technical matter for microbiologists, the former is an issue due to current approaches by gastroenterologists to obtain data on the physiology of the gut. The ideal solution to this problem would be a system that would either collect or measure in situ, without the need to change or perturb the gut ecosystem. This approach would provide information for the clinician on the "state of the gut," and whether it differs from what would be considered a normal gut. The swallowable capsule has the potential to provide this capability. These tiny devices can noninvasively access the gut. The devices can visualize the gut in the form of capsule endoscopes. Recent advances in the area are resulting in capsules with controlled movement, from either magnetic or electrical stimulation. Capsules with useful features, such as chemical sensors and dissolved gas sensors, are being developed to obtain more specific information on the gut. These capabilities can be used in addition to, or eventually instead of, the traditional markers of urine, blood, and feces.
Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors
Authors: Marianna B. Ruzinova, Rebecca A. Schoer, William Gerald, James E. Egan, Pier Paolo Pandolfi, Shahin Rafii, Katia Manova, Vivek Mittal, Robert Benezra
Journal: Cancer Cell (2003)
Treatment of Antiphospholipid Antibody Syndrome
Authors: Denis Wahl, Veronique Regnault
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urinary excretion of polyamines in patients with surgical and accidental trauma: Effect of total parenteral nutrition
Authors: Mikko J. Pöyhönen, Jukka A. Takala, Otto Pitkänen, Aarno Kari, Esko Alhava, Liisa A. Alakuijala, Terho O. Eloranta
Journal: Metabolism (1993)
Conversion to Sirolimus as Primary Immunosuppression Attenuates the Progression of Allograft Vasculopathy After Cardiac Transplantation
Authors: Eugenia Raichlin, Jang-Ho Bae, Zain Khalpey, Brooks S. Edwards, Walter K. Kremers, Alfredo L. Clavell, Richard J. Rodeheffer, Robert P. Frantz, Charanjit Rihal, Amir Lerman, Sudhir S. Kushwaha
Journal: Circulation (2007)

We investigated the potential of conversion to sirolimus (SRL) as a primary immunosuppressant in attenuating cardiac allograft vasculopathy progression.Twenty-nine cardiac transplant recipients were converted to SRL 3.8+/-3.4 years after transplantation with complete calcineurin inhibitor (CNI) withdrawal. Secondary immunosuppressants (azathioprine or mycophenolate) and steroids remained unchanged. Forty patients (controls) 4.8+/-4.0 years from transplantation were maintained on CNIs. Three-dimensional intravascular ultrasound studies were performed at baseline and 12.1+/-2.6 months later. Mean plaque (media and intima) volume (PV) and plaque index (PI) (PV/vessel volume percent) increased significantly in the CNI group (1.28+/-2.86 mm(3)/mm, P=0.004; and 6+/-8%, P=0.0001) but not in the SRL group (0.1+/-1.13 mm(3)/mm, P=0.63; and 0.1+/-8%, P=0.94). In patients enrolled within 2 years after transplantation, the increases in PV (0.06+/-1.06 versus 1.77+/-1.65 mm(3)/mm; P=0.0081) and PI (0+/-9% versus 10+/-8%; P=0.0145) were smaller in the SRL group (n=11) than in the CNI (n=12) group. In patients enrolled >/=2 years after transplantation, the increase in PI was less in the SRL group compared with the CNI group (0.1+/-6.5% versus 5+/-8%; P=0.033), but changes in PV did not differ significantly. Treatment with azathioprine or mycophenolate did not affect PV or PI in either the SRL group (PV: 0.22+/-0.66 versus 0.05+/-1.45 mm(3)/mm, P=0.46; PI: 1.5+/-6% versus -1.6+/-8.5%, P=0.29) or the CNI group (PV: 1.42+/-1.39 versus 1.06+/-2.28 mm(3)/mm, P=0.49; PI: 7.8+/-8.7% versus 4.8+/-7.3%, P=0.23).Substituting CNI with SRL as primary immunosuppression attenuates cardiac allograft vasculopathy progression.
Trifluoperazine in Alcoholic Hallucinosis
Authors: David G. Logan
Journal: JAMA (1967)

To the Editor:—  Alcoholic auditory hallucinosis is a distinct clinical entity. It is probably a form of alcoholic withdrawal, but it is clearly separable from the more common syndromes, the tremulous-mixed auditory and the visual hallucinatory-epileptic-delirious states. 1 (Table)  A small percentage of patients with alcoholic hallucinosis will have persistent auditory hallucinations, progressive withdrawal and suspiciousness, and eventually a delusional hallucinatory state indistinguishable from chronic paranoid schizophrenia.  Currently drugs for all alcoholic withdrawal states are chosen for effectiveness in prevention of death and control of behavior. 2 Prevention of progression to chronic auditory hallucinosis should be the goal of drug therapy in alcoholic auditory hallucinosis. The following case suggests trifluoperazine is highly effective in this regard.  Report of a Case:—  A 54-year-old white woman was admitted with the complaint that voices were threatening her with violence. For six weeks she had been awakening at night hearing her husband's voice admitting
Hemoglobinopathies in the dogon country: Presence of β<sup>s</sup>, β<sup>c</sup>, and δ<sup>a'</sup>genes
Authors: Rolande Ducrocq, Mohcine Bennani, Gil Bellis, Mounirou Baby, Kader Traore, Ronald L. Nagel, Rajagopal Krishnamoorthy, Andre Chaventre
Journal: American Journal of Hematology (1994)

Abstract The population of the Dogon, located in Mali, is divided in an endogamic Noble class and two endogamic servant castes (Tanners and Blacksmiths). We find that the polymorphic frequencies of β c , β s , and, unexpectedly, a mutation of the δ‐chain (δ A' ), are geographically (valley vs. plateau) as well as social status dependent. © 1994 Wiley‐Liss, Inc.
PHARMACOLOGY AND THE MEDICAL SCHOOLS
Authors: CHARLES W. EDMUNDS
Journal: JAMA (1930)

I may perhaps be excused if I err in drawing the conclusion that Fellows of the American Medical Association in attendance on the meetings of the Section on Pharmacology and Therapeutics have a certain interest in the two subjects pharmacology and the medical schools. I wish, therefore, to discuss some of the problems which confront them, to examine into the cause of their difficulties and to study their effects, even if I cannot outline the treatment. In the first place, it may be asked whether there really is trouble in the pharmacologic world and, if so, why? What are its complaints and are they justified? Its main trouble may be most briefly stated by saying that the followers of pharmacology complain most of a lack of recognition of the importance of the subject in certain of the medical schools in the country. This has led in many cases to insufficient
Objective measurement of three epidermal parameters in psoriasis vulgaris and in dermatopathology in general
Authors: D. M. CHAPMAN, J. B. ROSS
Journal: British Journal of Dermatology (1988)

Three objective parameters which characterize the main features of the epidermis are described. One parameter relates to the mean thickness of the epidermis determined by a simple method. The second descriptive number is the ratio of the thickness of the strata corneum, lucidum and granulosum to the stratum malpighii. The third number relates to the degree of folding of the dermo-epidermal junction. The ratio of the mean thickness of abnormal to normal stratum corneum (for the same skin region) is suggested as an objective measure of hyperkeratosis; likewise, the ratio of abnormal to normal stratum malpighii is an objective measure of acanthosis. A single parameter can be measured against time to follow changes during the pathogenesis, treatment or remission of epidermal disease. As psoriasis undergoes progressive acanthosis, the geometry of the folding of the dermo-epidermal junction is such that cells of the stratum malpighii retain their close association with the cylindrical dermal papillae.
Anna, Mary, Rose
Authors: Michael Buenaflor
Journal: JAMA (1986)

Long before the current go-around with the federal government and at a time when young, newly trained physicians were considered poor businessmen if they did take part, I chose to be a Medicare-participating practitioner. Some of my peers had what they called "strong principles" that did not allow them to do likewise. Today I accept that I may be in the minority of physicians, but I am an old softy for my senior citizens and am proud of it. Some doctors tried to discourage me when I chose the community in which I now practice. They felt its ethnic base, blue-collar economy, and somewhat off the beaten track location would not contribute to a successful practice. I took it as a challenge. When I opened my practice in 1979, prospective patients would walk into my office unannounced just to look around and to glimpse the new doctor. I was frequently
Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: a new molecular target for detection of minimal residual disease
Authors: A Beishuizen, MAC de Bruijn, MJ Pongers-Willemse, M-A J Verhoeven, ER van Wering, K Hählen, TM Breit, S de Bruin-Versteeg, H Hooijkaas, JJM van Dongen
Journal: Leukemia (1997)
Promotion of Collateral Growth by Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Coronary Artery Disease
Authors: Christian Seiler, Tilmann Pohl, Kerstin Wustmann, Damian Hutter, Pierre-Alain Nicolet, Stephan Windecker, Franz R. Eberli, Bernhard Meier
Journal: Circulation (2001)

Background Experimentally, activated macrophages have been documented to induce vascular proliferation. Methods and Results In 21 patients (age 74±9 years) with extensive coronary artery disease not eligible for coronary artery bypass surgery, the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF, Molgramostim) on quantitatively assessed collateral flow was tested in a randomized, double-blind, placebo-controlled fashion. The study protocol consisted of an invasive collateral flow index (CFI) measurement immediately before intracoronary injection of 40 μg of GM-CSF (n=10) or placebo (n=11) and after a 2-week period with subcutaneous GM-CSF (10 μg/kg) or placebo, respectively. CFI was determined by simultaneous measurement of mean aortic pressure (P ao , mm Hg), distal coronary occlusive pressure (P occl , mm Hg; using intracoronary sensor guidewires), and central venous pressure (CVP, mm Hg): CFI=(P occl −CVP)/(P ao −CVP). CFI, expressing collateral flow during coronary occlusion relative to normal antegrade flow during vessel patency, changed from 0.21±0.14 to 0.31±0.23 in the GM-CSF group ( P &lt;0.05) and from 0.30±0.16 to 0.23±0.11 in the placebo group ( P =NS). The treatment-induced difference in CFI was +0.11±0.12 in the GM-CSF group and -0.07±0.12 in the placebo group ( P =0.01). ECG signs of myocardial ischemia during coronary balloon occlusion occurred in 9 of 10 patients before and 5 of 10 patients after GM-CSF treatment ( P =0.04), whereas they were observed in 5 of 11 patients before and 8 of 11 patients after placebo ( P =NS). Conclusions This first clinical study investigating the potential of GM-CSF to improve collateral flow in patients with coronary artery disease documents its efficacy in a short-term administration protocol.
Drugs and Esophagitis: One Banana Makes a Swallow
Authors: Hans H. Neumann
Journal: JAMA (1985)

To the Editor.—  Recent letters on drug-induced esophagitis from stagnant capsules or pills 1 and the original article by Amendola and Spera 2 touch on a subject of much interest in everyday practice. This disorder is probably more prevalent than it would appear from reports in the literature, and the range of offending drugs much wider than that listed in the commentary.  The question is, how can this common occurrence be prevented? Since capsules and pills can linger in the esophagus for lengthy periods if swallowed with small amounts of water, and particularly if the patient assumes a recumbent position, Hey et al 3 suggest that patients should not only drink much water (almost a teacup full) but should remain standing for a minute and a half.  These suggestions are not always easy to follow. A simple method that is also useful for recumbent patients is to swallow a few bites of
Infection with Eaton's Primary Atypical Pneumonia Agent in England
Authors: G. M. Goodburn, B. P. Marmion, E. J. C. Kendall
Journal: BMJ (1963)

CANCERMEDICALJOUAL assessment of all relevant facts which might lead to the formulation of relative or absolute survival rates.Furthermore, our knowledge of such things as average life expectancy and life expectancy of untreated patients with particular forms of cancer is so incomplete that such elegant studies are impossible at this time.It is hoped that efforts to operate a minimal follow-up system will enable us to complete this study along these lines.Summary A review of 110 cases of oral cancer treated at the radiotherapy department of the Port Moresby General Hospital was made.The incidence of oral cancer in patients reaching hospital in Papua and New Guinea is higher than is found in European communities, but the overall incidence may be lower than that in countries of South-east Asia, for instance, where tobacco is chewed with betel nut.The age and sex incidence of the condition in our patients differs from those found in European com- munities, but there is a similarity with figures from the countries of South-east Asia.The relatively high incidence of oral cancer compared with other cancers is thought to be due partly to easy detectability of the cancer in an accessible site.Properly conducted clinical studies might throw light on environ- mental and racial factors in the development of oral tumours.This paper is published with the permission of Dr.