tbuckley/cabot-search huggingface dataset:
Nerve growth factor and its receptor system in psoriasis
Authors: S.P. Raychaudhuri, W-Y. Jiang, B.R. Smoller, E.M. Farber
Journal: British Journal of Dermatology (2000)

Journal Article Nerve growth factor and its receptor system in psoriasis Get access S.P. Raychaudhuri, S.P. Raychaudhuri Psoriasis Research Institute, 600 Town and Country Village, Palo Alto, CA 94306, U.S.A. *Department of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A. Correspondence: Prof. Eugene M.Farber Search for other works by this author on: Oxford Academic Google Scholar W‐Y. Jiang, W‐Y. Jiang Psoriasis Research Institute, 600 Town and Country Village, Palo Alto, CA 94306, U.S.A. *Department of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A. Correspondence: Prof. Eugene M.Farber Search for other works by this author on: Oxford Academic Google Scholar B.R. Smoller, B.R. Smoller Psoriasis Research Institute, 600 Town and Country Village, Palo Alto, CA 94306, U.S.A. *Department of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A. Correspondence: Prof. Eugene M.Farber Search for other works by this author on: Oxford Academic Google Scholar E.M. Farber E.M. Farber Psoriasis Research Institute, 600 Town and Country Village, Palo Alto, CA 94306, U.S.A. *Department of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A. Correspondence: Prof. Eugene M.Farber Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 1, 1 July 2000, Pages 198–200, https://doi.org/10.1046/j.1365-2133.2000.03617.x Published: 01 July 2000
The Works of William Harvey
Authors: Michael T. Walton
Journal: JAMA (1990)

The importance of William Harvey to the development of physiology can scarcely be overstated. His study of the relationship of the pulse to the heartbeat, which led to his discovery of the circulation of the blood, is a model of experimental elegance. Harvey's sense of experimental design has been equaled only by scientists like Koch and Hodgkin. Modern physicians and biological scientists can profitably read Harvey's works for their historical importance and their exemplary clear thinking. The eighth chapter of<i>De motu cordis</i>is especially illustrative of Harvey's ability to explicate his ideas and discoveries in the context of then current scientific opinion. The translation from Latin of Harvey's works by Robert Willis, MD, is a venerable one, first published by the Sydenham Society in 1847. It has the charm of a translation prepared before the full flowering of scientific medicine. While it does not meet the technical needs of
Re: Shahrokh F. Shariat, Richard Zigeuner, Michael Rink, et al. Subclassification of pT3 Urothelial Carcinoma of the Renal Pelvicalyceal System is Associated With Recurrence-Free and Cancer-Specific Survival: Proposal for a Revision of the Current TNM Classification. Eur Urol. In press. DOI:10.1016/j.eururo.2012.01.019
Authors: Toyonori Tsuzuki, Naoto Sassa, Momokazu Gotoh
Journal: European Urology (2012)
Sodium and Fluid Restriction—Reply
Authors: Graziella Aliti, Eneida Rejane Rabelo, Luís Beck-da-Silva
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Isolated subcutaneous Candidal abscess and HIV disease
Authors: R. Manfredi, A. Mazzoni, A. Nanetti, A. Mastroianni, O.V. Coronado, F. Chiodo
Journal: British Journal of Dermatology (1997)

Journal Article Isolated subcutaneous Candidal abscess and HIV disease Get access R. Manfredi, R. Manfredi Department of Clinical and Experimental Medicine. Division of Infectious Diseases Search for other works by this author on: Oxford Academic Google Scholar A. Mazzoni, A. Mazzoni Division of Microbiology, University of Bologna, Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Nanetti, A. Nanetti Division of Microbiology, University of Bologna, Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar A. Mastroianni, A. Mastroianni Department of Clinical and Experimental Medicine. Division of Infectious Diseases Search for other works by this author on: Oxford Academic Google Scholar O.V. Coronado, O.V. Coronado Department of Clinical and Experimental Medicine. Division of Infectious Diseases Search for other works by this author on: Oxford Academic Google Scholar F. Chiodo F. Chiodo Department of Clinical and Experimental Medicine. Division of Infectious Diseases Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 4, 1 April 1997, Pages 647–649, https://doi.org/10.1111/j.1365-2133.1997.tb02177.x Published: 01 April 1997
Complications of Direct-Current Countershock
Authors: Edward M. Vigliano
Journal: JAMA (1965)

<h3>To the Editor:—</h3> In the communication by Rabbino, Likoff, and Dreifus on complications and limitations of direct-current precordial countershock (<i>JAMA</i><b>190</b>:417 [Nov 2] 1964) there are three examples of ventricular fibrillation. The preshock electrocardiographic tracing of case 1 is described in the text and in Fig 1 as paroxysmal atrial tachycardia with 2:1 atrioventricular block. A close examination of the tracing, however, reveals a double tachycardia, with a regular atrial rate of 250 beats per minute, and a regular nodal mechanism at 150 beats per minute, with complete dissociation and heart block. It seems necessary to correct this error since a final list of indications and contraindications for this valuable form of therapy must take into account the exact electrocardiographic mechanism of the arrhythmia.
Abstract 140: Tumor suppressor role of microRNA-1 in prostate cancer
Authors: Robert S. Hudson, Ming Yi, Dominic Esposito, Robert M. Stephens, Carlo M. Croce, Stefan Ambs
Journal: Cancer Research (2011)

Abstract MicroRNAs (miRNA) are small non-coding RNAs that reduce the translation of target mRNAs via 3’ untranslated region (UTR) binding sites. MicroRNA-1 has been previously shown by genome-wide studies in our lab to be under-expressed in prostate cancer (PCa) tissues and lost in most of the NCI-60 cell lines. We hypothesize that miRNA-1 plays a role in the progression of PCa through tumor suppressor mechanisms. To explore this we used an integrated system biology approach by re-expressing miRNA-1 and studying its targetome by mRNA microarray analysis, miRNA target prediction, pathway analysis, and connectivity mapping. From these analyses we found that miRNA-1 down-regulated transcripts were significantly enriched for predicted targets and genes involved in cell cycle progression, mitosis, and DNA replication/repair. Following this we found evidence that miRNA-1 could increase the number of cells in S-phase while reducing mitotic cell numbers and the protein levels of genes required for S-phase progression including CHK1 and MCM7. Connectivity mapping of miRNA-1 expression profiles revealed that the effects of this miRNA overlap with histone deacetylase inhibitors like Vorinostat and Trichostain (TSA). Supporting this we found that miRNA-1 could be re-expressed when PCa cells were treated with epigenetic drugs such as 5-azadeoxycytidine and TSA. This could implicate a downstream role of miRNA-1 in these epigenetic mechanisms. Moreover, miRNA-1 expression increased radiation mediated levels and resolution of the DNA damage biomarker gamma-H2A.X, while reducing the clonogenic survival of PCa cells to radiation. This indicates that the loss of miRNA-1 could have clinical importance, by leading to an increase in the survivability of PCa cells to radiation therapy. Further, we found that several possible targets of miRNA-1 are actin binding genes that could play roles in both mitosis and migration. Using 3’UTR reporter assays we found that miRNA-1 directly targets several of these genes including, LASP-1, XPO6, NOTCH-3, FN1, MMD, and PTMA. Subsequently, epi-fluorescence microscopy revealed that miRNA-1 was capable of increasing F-actin levels and altering its organization in PCa cells. In conclusion, our findings indicate that miRNA-1 functions as a tumor suppressor in PCa by influencing cell cycle, the DNA damage response, and regulating actin related genes involved in mitosis and cell motility. These studies implicate a possible utility of miRNA-1 expression patterns in the therapeutic outcome of PCa patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 140. doi:10.1158/1538-7445.AM2011-140
Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase
Authors: Antonija Jurak Begonja, Jörg Geiger, Natalia Rukoyatkina, Steffen Rauchfuss, Stepan Gambaryan, Ulrich Walter
Journal: Blood (2006)
Investigation of Aortic Elastic Parameters [Aortic Distensibility (AD) and Aortic Straın (AS)] and Aortic Propagation Velocity in Dilated Cardiomyopathy Patients with or without Critical Coronary Artery Disease
Authors: Mesut Gitmez, Kamuran Tekin, Ali Yıldız, Yusuf Sezen, Recep Demirbağ
Journal: Journal of the American College of Cardiology (2013)
Thiol-disulfide interchange in the binding of bence jones proteins to alpha-antitrypsin, prealbumin, and albumin.
Authors: C B Laurell, E Thulin
Journal: The Journal of Experimental Medicine (1975)

Native light Ig chains of kappa- but not of lambda-type form -S-S linked complexes with prealbumin, alpha1-AT and albumin in vivo. kappa-chains isolated from urines have cysteinyls which are more promptly reacting with dithionitrobenzoate (DTNB) than lambda-chains. Both are monomerized on this reaction. On addition to plasma mixed disulfides between both types of light chains and DTNB form larger amounts of complexes than the native chains. The lower reactivity of native lambda-chains to the plasma proteins can be explained by their higher dimer stability. From the light chain reactions obtained with isolated alpha1-AT and albumin it is concluded that alpha1-AT has a disulfide which efficiently interchanges with monomeric, light chain thiolate ions released from thionitrobenzoate derivates of light chains and that on interchange with the derivatized light chains albumin releases more free light chains into the solution than are bound to albumin. Addition of derivatized light chains to a mixture of alpha1-AT and albumin increases the yield of alpha1-AT complexes and decreases the amount of albumin complexes formed. The relative amount of the different complexes formed in the latter experiments corresponds to the findings in vivo in patients with Bence Jones proteinemia. Prealbumin and alpha1-AT in plasma have a roughly 10-fold stronger tendency to link the light chains than albumin. The complexes are formed through thiol-disulfide interchange though neither the disulfide of native alpha1-AT nor the thiols of prealbumin is available for reaction with DTNB. The three plasma proteins may together constitute a system for linkage and transport of peptides with reactive thiols or disulfides released into the extracellular fluids. The trypsin and elastase binding and inhibiting capacity of alpha1-AT remains after cleavage of the internal -S-S-bridge of alpha1-AT through interchange with a light chain thiol for which reason an intact internal -S-S-bridge of alpha1-AT is not necessary for inhibition and linkdage of the enzymes.
Sickle cell disorder, β-globin gene cluster haplotypes and α-thalassemia in neonates and adults from Guadeloupe
Authors: L. Kéclard, M. Romana, E. Lavocat, C. Saint-Martin, C. Berchel, G. Mérault
Journal: American Journal of Hematology (1997)

We have studied haplotype of βs chromosome and α-globin gene status in 534 patients (255 adults and 279 children of whom 159 neonates) from Guadeloupe with various sickle cell-related conditions, namely SS (n = 298), SC (n = 170), S-β -thal (n = 56), and other rare forms (n = 10). Haplotype data on βs chromosomes confirm our previous observation that Benin type is the most prevalent (75%) βs chromosome in Guadeloupe, in disagreement with the historical records. Comparison of the frequency of distribution of various βs haplotypes between neonates and adults on the one hand and between SS and SC cases on the other shows that the current βs haplotype distribution in this island is not distorted by haplotype-related differential survival. We also show that the frequency of α-thalassemia (-3.7 kb) in Guadeloupe is one of the highest recorded in this region involved in Atlantic slave trade and also failed to reveal any age-dependent increase in frequency. We conclude that the African component of Guadeloupe is distinct from that of Brazil and Cuba but is close to that of Jamaica. Am. J. Hematol. 55:24-27, 1997. © 1997 Wiley-Liss, Inc.
Allergenicity and immunochemical characterization of six varieties of Olea europaea
Authors: J. Carnes Sanchez, V. M. Iraola, J. Sastre, F. Florido, L. Boluda, E. Fernandez-Caldas
Journal: Allergy (2002)

The inhalation of Olea europaea pollen is one of the most important causes of allergic respiratory diseases in the Mediterranean basin. The objective of this study was to investigate the antigenic and allergenic composition of six different O. europaea varieties collected in southern Spain.The varieties included in the study were: Acebuche (wild olive), Carrasqueño, Nevado, Hojiblanco, Manzanillo and Picual. Extracts of these six varieties were prepared. Twenty-nine olive individuals with an immunoglobulin(Ig)E-mediated allergy to olive pollen were skin tested with these extracts. The antigenic profile of these extracts was evaluated by SDS-PAGE; the allergenic profile was investigated by immunoblotting using the serum of these 29 individuals. The Ole e 1 content was established by ELISA inhibition using purified Ole e 1 and rabbit polyclonal antibodies and by scanning densitometry.The extracts that induced the smallest wheal size were Acebuche and Hojiblanco, being significantly different from the rest of the extracts. The antigenic and allergenic profiles of the extracts also varied. The Ole e 1 content ranged from 0.050 in Hojiblanco to 0.232 in Manzanillo, measured by ELISA inhibition and from 0.153 in Hojiblanco to 0.677 in Nevado, measured by scanning densitometry.The different varieties of O. europaea pollen studied demonstrated great differences in the in vivo and in vitro potency of the extracts. There were significant differences in the Ole e 1 content, while the protein content remained very similar in these extracts. This study confirms previous observations of a great variability in the antigenic and allergenic composition of O. europaea pollen extracts and establishes significant differences in Ole e 1 content.
Objective Assessment of Smoking Habits by Urinary Cotinine Measurement in Adolescents and Young Adults With Type 1 Diabetes: Reliability of reported cigarette consumption and relationship to urinary albumin excretion
Authors: Reinhard W Holl, Mathias Grabert, Eberhard Heinze, Klaus-Michael Debatin
Journal: Diabetes Care (1998)

OBJECTIVE To examine the relationship of objective smoking status to age, sex, longterm metabolic control, and urinary albumin excretion. Patients with type 1 diabetes who smoke are at increased risk to develop diabetic microvascular and macrovascular complications. While this has repeatedly been demonstrated in adults, smoking habits have rarely been investigated in adolescents. RESEARCH DESIGN AND METHODS Urinary cotinine excretion has been determined by radioimmunoassay in 238 adolescents and young adults with type 1 diabetes. This biochemical parameter of nicotine use was related to age, to the number of cigarettes allegedly consumed per day, and to urinary albumin excretion. RESULTS A total of 46 patients (19.3%) with urinary cotinine values &amp;gt;500 ng/ml were classified as smokers. In 26 patients (10.9%), cotinine values between 100 and 500 ng/ml were found (infrequent smokers or environmental nicotine exposure), while the remaining 166 patients excreted &amp;lt;100 ng/ml of cotinine in the urine (nonsmokers). Smokers were significantly older (20.2 ± 0.6 years [mean ± SE]) compared with the intermediate group (18.3 ± 0.7 years) or with nonsmokers (15.9 ± 0.4 years; P &amp;lt; 0.0001, Wilcoxon's signed-rank test). Of 46 smokers, 12 denied smoking cigarettes entirely, and among biochemically defined smokers, no correlation was present between urinary cotinine excretion and the reported number of cigarettes consumed per day. Urinary albumin excretion was significantly higher in smokers compared with nonsmokers (P &amp;lt; 0.003). CONCLUSIONS These data demonstrate that cigarette smoking is common among German adolescents and young adults with type 1 diabetes in this study. Many patients deny nicotine use or refuse to disclose their smoking habits. Increased urinary albumin excretion is consistent with an increased risk of nephropathy in subjects with diabetes who smoke. Pediatricians in charge of adolescents with type 1 diabetes should actively discuss the risk of nicotine consumption with their patients.
Results and Policy Implications of the Resource-Based Relative-Value Study
Authors: William C. Hsiao, Peter Braun, Daniel Dunn, Edmund R. Becker, Margaret DeNicola, Thomas R. Ketcham
Journal: New England Journal of Medicine (1988)

Abstract The resource-based relative-value scale (RBRVS) is a measure of relative levels of resource input expended when physicians produce services and procedures. It is a function of the physician's work input, the opportunity cost of specialty training, and the relative practice costs for each specialty. This paper presents resource-based relative values (RBRVs) for selected procedures of four major specialties — family practice, internal medicine, general surgery, and thoracic and cardiovascular surgery. We compare RBRVs with current charges and find several general patterns. Invasive procedures are typically compensated at more than double the rate of evaluation-and-management services, when both consume the same resource inputs. Imaging and laboratory procedures fall between invasive and evaluation-and-management services. We analyze the financial implications of the RBRVS by developing a simple model and simulating the effects of an RBRVS-based fee schedule on physicians' revenues in various specialties. We use Medicare data to perform the simulation under the "budget-neutral" assumption. Results show that an RBRVS-based fee schedule affects specialties differently. The average family practitioner could receive 60 percent more revenue from Medicare, whereas the average ophthalmologist could lose 40 percent of current revenues. The effects on other specialties fall between these two.
Hospital Programs of Blood Banking
Authors: Robert F. Norris
Journal: JAMA (1965)

Hospital blood banks today vary in size from those which are subdivisions of small community hospitals to those which are major divisions of large metropolitan hospitals or medical centers. Blood banking evolved very rapidly following World War II from simple beginnings. Prior to that time, procurement of blood for a patient was a matter of urgently typing friends and relatives in the hope of obtaining several pints of blood which would be compatible. The rapid evolution of blood banking has been the result of a combination of factors. With the introduction of the now well known anticoagulant citric acid dextrose solution which preserves blood for three weeks, and with the discovery of the Rh factors, it became technically possible, on the one hand, to undertake the storage of blood prior to the need for transfusion and it became necessary, on the other hand, to have expert study and supervision of
Graves's Disease: Clinical Types and their Management
Authors: F. F. Rundle
Journal: BMJ (1951)

In both there is overproduction of thyroid hormone, but in other respects there are important differences. The precise aetiological relationship, for example, between secondary toxic goitre and classic Graves's disease is still not clear. On another side Graves's disease merges into the anxiety states, autonomie imbalance, and neurocircula tory asthenia. On still another there are the gross and intriguing conditions of exophthalmos and ophthalmo plegia that still baffle our comprehension. Beyond are even more obscure linkages with other endocrino pathies, conditions with thymic enlargement, and myopathies. Classification
Adipose and Muscle Tissue Profile of CD36 Transcripts in Obese Subjects Highlights the Role of CD36 in Fatty Acid Homeostasis and Insulin Resistance
Authors: Terri A. Pietka, Timothy Schappe, Caterina Conte, Elisa Fabbrini, Bruce W. Patterson, Samuel Klein, Nada A. Abumrad, Latisha Love-Gregory
Journal: Diabetes Care (2014)

Fatty acid (FA) metabolism is tightly regulated across several tissues and impacts insulin sensitivity. CD36 facilitates cellular FA uptake, and CD36 genetic variants associate with lipid abnormalities and susceptibility to metabolic syndrome. The objective of this study was to gain insight regarding the in vivo metabolic influence of muscle and adipose tissue CD36. For this, we determined the relationships between CD36 alternative transcripts, which can reflect tissue-specific CD36 regulation, and measures of FA metabolism and insulin resistance.The relative abundance of alternative CD36 transcripts in adipose tissue and skeletal muscle from 53 nondiabetic obese subjects was measured and related to insulin sensitivity and FA metabolism assessed by hyperinsulinemic-euglycemic clamps and isotopic tracers for glucose and FA.Transcript 1C, one of two major transcripts in adipose tissue, that is restricted to adipocytes predicted systemic and tissue (adipose, liver, and muscle) insulin sensitivity, suggesting adipocyte CD36 protects against insulin resistance. Transcripts 1B and 1A, the major transcripts in skeletal muscle, correlated with FA disposal rate and triglyceride clearance, supporting importance of muscle CD36 in clearance of circulating FA. Additionally, the common CD36 single nucleotide polymorphism rs1761667 selectively influenced CD36 transcripts and exacerbated insulin resistance of glucose disposal by muscle.Alternative CD36 transcripts differentially influence tissue CD36 and consequently FA homeostasis and insulin sensitivity. Adipocyte CD36 appears to be metabolically protective, and its selective upregulation might have therapeutic potential in insulin resistance.
Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM)
Authors: Patricia A. Taylor, Angela Panoskaltsis-Mortari, Gordon J. Freeman, Arlene H. Sharpe, Randolph J. Noelle, Alexander Y. Rudensky, Tak W. Mak, Jonathan S. Serody, Bruce R. Blazar
Journal: Blood (2004)