tbuckley/cabot-search huggingface dataset:
Calcium Channel Antagonists and Gingival Hyperplasia
Authors: C. David Naylor
Journal: Annals of Internal Medicine (1994)

Letters15 October 1994Calcium Channel Antagonists and Gingival HyperplasiaC. David Naylor, MD, DPhilC. David Naylor, MD, DPhilSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-8-199410150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the report by Steele and colleagues [1] on calcium antagonist-induced gingival hyperplasia.The authors reported that none of the affected patients had “severe hyperplasia.” They sketched some potential complications but also noted that only one of their patients required surgical attention for gingival overgrowth. No data were given on how often the patients were troubled by the changes in their gums.How does this evidence support the recommendation that physicians “examine patients who are to be treated with a calcium antagonist for gingival overgrowth?” Because many older patients with ischemic heart disease already ...REFERENCE1. Steele RM, Schuna AA, Schreiber RT. Calcium anatagonist-induced gingival hyperplasia. Ann Intern Med. 1994; 120:663-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byApplication of evidence-based dentistry: from research to clinical periodontal practice 15 October 1994Volume 121, Issue 8Page: 624-625KeywordsAdverse reactionsCalciumCalcium channel blockerCardiovascular therapyElderly ePublished: 15 August 2000 Issue Published: 15 October 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
13PHD1 deficiency promotes an atheroprotective metabolic phenotype
Authors: E Marsch, J Demandt, T Theelen, MJ Gijbels, PCN Rensen, P Carmeliet, EA Fisher, EAL Biessen, MJAP Daemen, JC Sluimer
Journal: Cardiovascular Research (2014)

Knockout of the oxygen-sensor HIF prolyl hydroxylase 1 (PHD1) was shown to switch metabolism towards glycolysis and reduced cellular oxygen consumption. As we recently showed a pro-atherosclerotic effect of plaque hypoxia, we hypothesised that reduced cellular oxygen consumption in PHD1 knockout mice alleviates atherosclerosis development.
Influenza Vaccination in Elderly Patients With Advanced Colorectal Cancer
Authors: Craig C. Earle
Journal: Journal of Clinical Oncology (2003)

To examine influenza vaccination use in patients undergoing chemotherapy for advanced cancer.All Medicare patients treated for stage IV colorectal cancer between 1993 and 1998 while living in one of the regions monitored by the Survival, Epidemiology, and End Results Program who were alive in the fall months and who survived at least 4 months with their cancer were considered eligible to have received vaccination. Their medical bills were analyzed to determine receipt of influenza vaccination and subsequent outcomes.Eligibility criteria were met by 1,225 patients who were undergoing chemotherapy during 1,577 person-years of observation. Overall, 39.7% of patients received influenza vaccination, increasing from 26% in 1993 to 43% in 1998. When vaccination was administered, it was provided by primary care physicians 68% of the time. Vaccinated patients were more likely to be white, of higher socioeconomic status, and to have more comorbidity. Fewer diagnoses of influenza and pneumonia infections were made in vaccinated patients while undergoing treatment. Those patients who were immunized also had fewer chemotherapy interruptions and were more likely to survive through to the beginning of the next fall (hazard ratio, 0.88; 95% confidence interval, 0.77 to 0.99). There was a trend toward decreased resource use among immunized patients.This study observed outcomes associated with influenza vaccination that are similar to those reported for patients without cancer. However, rates of immunization are relatively low, and disparities exist for vulnerable populations. As part of delivering high-quality care, oncologists should promote influenza vaccination for their patients who are undergoing treatment for advanced cancer.
Registration of Still-Born Infants
Authors: F. Buckell, T. Mann
Journal: BMJ (1843)

there were any cases of suppression of urine, except- ing in cholera, without disorganisation of the struc- ture of the kidneys.Experience in these cases did not lead him to believe in the assertion of Sir Henry Halford, which he had made in his paper in the "Transactions of the College of Physicians," that
Somatostatin binding in human gastrointestinal tissues: effect of cations and somatostatin analogues.
Authors: G V Miller, S R Preston, L F Woodhouse, S M Farmery, J N Primrose
Journal: Gut (1993)

This study characterises the somatostatin binding site in human gastrointestinal cancer and mucosa in terms of cationic specificity and relative affinity for three somatostatin analogues. Competitive displacement assays were performed on plasma membranes from human gastric and colonic tissues using radiolabelled somatostatin-14 as ligand. Comparison was made with the somatostatin binding site in rat cerebral cortex. In gastrointestinal tissue, magnesium decreased and sodium increased specific binding. By contrast, in rat cerebral cortex, the converse cationic effect was seen. These changes resulted from alterations in receptor density, with no change in receptor affinity. Displacement studies were then performed with somatostatin-14 and somatostatin analogues RC-160, somatuline, and octreotide. RC-160 and somatuline displaced radiolabel from binding sites in gastric and colonic cancer and mucosa with 10-fold lower affinity than the native peptide. Octreotide did not displace radioligand in gastric or colonic cancer at any concentration tested. By contrast, in rat cortex, although all three analogues displaced with a lower affinity than the native peptide, there was no difference between analogues. These data suggest a distinct somatostatin receptor subtype in gastrointestinal tissues.
Prosthetic gestures: How the tool shapes the mind
Authors: Lambros Malafouris
Journal: Behavioral and Brain Sciences (2012)

Abstract I agree with Vaesen that it is a mistake to discard tool use as a hallmark of human cognition. I contend, nonetheless, that tools are not simply external markers of a distinctive human mental architecture. Rather, they actively and meaningfully participate in the process by which hominin brains and bodies make up their sapient minds.
Glycosaminoglycans as Potential Regulators of Osteoprotegerin Therapeutic Activity in Osteosarcoma
Authors: Francois Lamoureux, Gaëlle Picarda, Laure Garrigue-Antar, Marc Baud'huin, Valerie Trichet, André Vidal, Elisabeth Miot-Noirault, Bruno Pitard, Dominique Heymann, Françoise Rédini
Journal: Cancer Research (2009)

Abstract Osteosarcoma is the most frequent primary bone malignant tumor that develops mainly in children and adolescents. Despite recent improvements in chemotherapy and surgery, survival rate is ∼50% after 5 years. Osteoprotegerin (OPG) is a potent inhibitor of osteoclast differentiation and activation, but its use as therapeutic agent in cancer-associated osteolysis remains controversial due to its ability to bind and inhibit the apoptotic effect of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) on tumor cells. The therapeutic effects of full-length OPG (1-401) and OPG 1-194 lacking its heparin-binding domain delivered by nonviral gene therapy were compared in a murine model of osteolytic osteosarcoma. Tumor incidence, progression, and associated bone lesions were significantly diminished in the OPG 1-194 group, but not in the OPG 1-401 group, compared with controls. As receptor activator of nuclear factor-κB ligand (RANKL), TRAIL, and glycosaminoglycans (GAG) were shown to be overexpressed in osteosarcoma environment compared with control tissue, OPG 1-401 bioactivity may be modulated by one of these protagonists. Surface plasmon resonance analyses performed with OPG, TRAIL, and GAGs revealed that TRAIL binds both forms of OPG with the same affinity. In addition, as OPG 1-194 and OPG 1-401 similarly inhibit TRAIL-induced apoptosis, it suggests that TRAIL is not involved in the modulation of OPG bioactivity. However, as GAGs inhibit OPG 1-401 but not OPG 1-194 binding to TRAIL or to RANKL, they may represent potent regulators of OPG availability and antitumor activity in bone tumor microenvironment. [Cancer Res 2009;69(2):526–36]
miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation
Authors: Takahiro Masaki, Kyle C. Arend, You Li, Daisuke Yamane, David R. McGivern, Takanobu Kato, Takaji Wakita, Nathaniel J. Moorman, Stanley M. Lemon
Journal: Cell Host & Microbe (2015)
In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish
Authors: Longhou Fang, Simone R. Green, Ji Sun Baek, Sang-Hak Lee, Felix Ellett, Elena Deer, Graham J. Lieschke, Joseph L. Witztum, Sotirios Tsimikas, Yury I. Miller
Journal: Journal of Clinical Investigation (2011)

Oxidative modification of LDL is an early pathological event in the development of atherosclerosis. Oxidation events such as malondialdehyde (MDA) formation may produce specific, immunogenic epitopes. Indeed, antibodies to MDA-derived epitopes are widely used in atherosclerosis research and have been demonstrated to enable cardiovascular imaging. In this study, we engineered a transgenic zebrafish with temperature-inducible expression of an EGFP-labeled single-chain human monoclonal antibody, IK17, which binds to MDA-LDL, and used optically transparent zebrafish larvae for imaging studies. Feeding a high-cholesterol diet (HCD) supplemented with a red fluorescent lipid marker to the transgenic zebrafish resulted in vascular lipid accumulation, quantified in live animals using confocal microscopy. After heat shock-induced expression of IK17-EGFP, we measured the time course of vascular accumulation of IK17-specific MDA epitopes. Treatment with either an antioxidant or a regression diet resulted in reduced IK17 binding to vascular lesions. Interestingly, homogenates of IK17-EGFP-expressing larvae bound to MDA-LDL and inhibited MDA-LDL binding to macrophages. Moreover, sustained expression of IK17-EGFP effectively prevented HCD-induced lipid accumulation in the vascular wall, suggesting that the antibody itself may have therapeutic effects. Thus, we conclude that HCD-fed zebrafish larvae with conditional expression of EGFP-labeled oxidation-specific antibodies afford an efficient method of testing dietary and/or other therapeutic antioxidant strategies that may ultimately be applied to humans.
Effects of Vitamin D3-Binding Protein-Derived Macrophage Activating Factor (GcMAF) on Angiogenesis
Authors: S. Kanda
Journal: JNCI Journal of the National Cancer Institute (2002)

Background: The vitamin D3-binding protein (Gc protein)-derived macrophage activating factor (GcMAF) activates tumoricidal macrophages against a variety of cancers indiscriminately. We investigated whether GcMAF also acts as an antiangiogenic factor on endothelial cells. Methods: The effects of GcMAF on angiogenic growth factor-induced cell proliferation, chemotaxis, and tube formation were examined in vitro by using cultured endothelial cells (murine IBE cells, porcine PAE cells, and human umbilical vein endothelial cells [HUVECs]) and in vivo by using a mouse cornea micropocket assay. Blocking monoclonal antibodies to CD36, a receptor for the antiangiogenic factor thrombospondin-1, which is also a possible receptor for GcMAF, were used to investigate the mechanism of GcMAF action. Results: GcMAF inhibited the endothelial cell proliferation, chemotaxis, and tube formation that were all stimulated by fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor-A, or angiopoietin 2. FGF-2-induced neovascularization in murine cornea was also inhibited by GcMAF. Monoclonal antibodies against murine and human CD36 receptor blocked the antiangiogenic action of GcMAF on the angiogenic factor stimulation of endothelial cell chemotaxis. Conclusions: In addition to its ability to activate tumoricidal macrophages, GcMAF has direct antiangiogenic effects on endothelial cells independent of tissue origin. The antiangiogenic effects of GcMAF may be mediated through the CD36 receptor.
NHS trusts have new duty to be honest about mistakes
Authors: C. Dyer
Journal: BMJ (2014)

A statutory duty of candour on all NHS trusts in England, requiring them to be open and honest with patients and their families, admit their mistakes, and apologise when things go wrong, came into force on 27 November.

Peter Walsh, chief executive of the patient safety charity Action against Medical Accidents, hailed the change, for which it had campaigned for two decades, as “the biggest advance in patient safety and patients’ …
DNA Vaccination in the Skin Using Microneedles Improves Protection Against Influenza
Authors: Jae-Min Song, Yeu-Chun Kim, Eunju O, Richard W Compans, Mark R Prausnitz, Sang-Moo Kang
Journal: Molecular Therapy (2012)

In this study, we tested the hypothesis that DNA vaccination in the skin using microneedles improves protective immunity compared to conventional intramuscular (IM) injection of a plasmid DNA vaccine encoding the influenza hemagglutinin (HA). In vivo fluorescence imaging demonstrated the expression of a reporter gene delivered to the skin using a solid microneedle patch coated with plasmid DNA. Vaccination at a low dose (3 µg HA DNA) using microneedles generated significantly stronger humoral immune responses and better protective responses post-challenge compared to IM vaccination at either low or high (10 µg HA DNA) dose. Vaccination using microneedles at a high (10 µg) dose further generated improved post-challenge protection, as measured by survival, recall antibody-secreting cell responses in spleen and bone marrow, and interferon (IFN)-γ cytokine T-cell responses. This study demonstrates that DNA vaccination in the skin using microneedles induces higher humoral and cellular immune responses as well as improves protective immunity compared to conventional IM injection of HA DNA vaccine. In this study, we tested the hypothesis that DNA vaccination in the skin using microneedles improves protective immunity compared to conventional intramuscular (IM) injection of a plasmid DNA vaccine encoding the influenza hemagglutinin (HA). In vivo fluorescence imaging demonstrated the expression of a reporter gene delivered to the skin using a solid microneedle patch coated with plasmid DNA. Vaccination at a low dose (3 µg HA DNA) using microneedles generated significantly stronger humoral immune responses and better protective responses post-challenge compared to IM vaccination at either low or high (10 µg HA DNA) dose. Vaccination using microneedles at a high (10 µg) dose further generated improved post-challenge protection, as measured by survival, recall antibody-secreting cell responses in spleen and bone marrow, and interferon (IFN)-γ cytokine T-cell responses. This study demonstrates that DNA vaccination in the skin using microneedles induces higher humoral and cellular immune responses as well as improves protective immunity compared to conventional IM injection of HA DNA vaccine.
THE EFFECT OF EICOSA 5:8:11:14 TETRAYNOIC ACID ON SKIN LIPID SYNTHESIS (14C INCORPORATION) IN VITRO
Authors: ROY SUMMERLY, SHEILA WOODBURY, H. J. YARDLEY
Journal: British Journal of Dermatology (1972)

Journal Article THE EFFECT OF EICOSA 5:8:11:14 TETRAYNOIC ACID ON SKIN LIPID SYNTHESIS (14C INCORPORATION) IN VITRO Get access ROY SUMMERLY, ROY SUMMERLY MRC Unit on the Experimental Pathology of Skin, The Medical School, Birmingham 15, and the Skin Department, North Staffordshire Hospital Centre, Stoke‐on‐Trent, Staffs Search for other works by this author on: Oxford Academic Google Scholar SHEILA WOODBURY, SHEILA WOODBURY MRC Unit on the Experimental Pathology of Skin, The Medical School, Birmingham 15, and the Skin Department, North Staffordshire Hospital Centre, Stoke‐on‐Trent, Staffs Search for other works by this author on: Oxford Academic Google Scholar H. J. YARDLEY H. J. YARDLEY MRC Unit on the Experimental Pathology of Skin, The Medical School, Birmingham 15, and the Skin Department, North Staffordshire Hospital Centre, Stoke‐on‐Trent, Staffs Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 6, 1 December 1972, Pages 608–613, https://doi.org/10.1111/j.1365-2133.1972.tb07451.x Published: 01 December 1972 Article history Accepted: 20 June 1972 Published: 01 December 1972
THE RESIDUAL SYNTAX SCORE FOR MORTALITY RISK ASSESSMENT IN ACUTE CORONARY SYNDROME WITH CARDIOGENIC SHOCK
Authors: Hidenori Adachi, Yoshinori Yasuoka, Kiyoshi Kume, Susumu Hattori, Yoshiki Noda, Ryo Araki, Ryo Matsutera, Motohiro Kosugi, Yasuaki Kohama, Tetsufumi Nakashima, Tatsuya Sasaki
Journal: Journal of the American College of Cardiology (2013)
Diabetic Nephropathy
Authors: James Lee Wilson, Howard F. Root, Alexander Marble
Journal: New England Journal of Medicine (1951)

SINCE the publication of the report by Kimmel-stiel and Wilson1 in 1936, much has been written and said about the intercapillary glomerulosclerosis seen frequently at post-mortem examination in older diabetic patients. Porter and Walker,2 Henderson, Sprague and Wagner,3 Rifkin and his co-workers4 and others5 6 7 have presented excellent discussions of the clinical picture considered to be due to such lesions. However, we have been impressed by the fact that in diabetic patients, both young and old, intercapillary glomerulosclerosis rarely if ever occurs as an isolated lesion and often seems relatively unimportant or may even be lacking. The renal involvement is almost . . .
High levels of energy expenditure in obese women.
Authors: A M Prentice, A E Black, W A Coward, H L Davies, G R Goldberg, P R Murgatroyd, J Ashford, M Sawyer, R G Whitehead
Journal: BMJ (1986)

Total free living energy expenditure was compared in lean and obese women by the new doubly labelled water method and partitioned into basal metabolism and thermogenesis plus activity by whole body calorimetry. Average energy expenditure was significantly higher in the obese group (10.22 versus 7.99 MJ/day (2445 versus 1911 kcal/day); p less than 0.001) resulting from an increase in the energy cost of both basal metabolism and physical activity. Self recorded energy intakes were accurate in the lean subjects but underestimated expenditure by 3.5 MJ/day (837 kcal/day) in the obese group. Basal metabolic rate and energy expenditure on thermogenesis plus activity were identical in the two groups when corrected for differences in fat free mass and total body mass. In the obese women in this series there was no evidence that their obesity was caused by a metabolic or behavioural defect resulting in reduced energy expenditure.
Inhibitory effects of ranitidine on flushing and serum serotonin concentrations in carcinoid syndrome
Authors: M Noppen, A Jacobs, S Van Belle, P Herregodts, G Somers
Journal: BMJ (1988)

CommentCirculating antibodies to collagen are present in the blood of 45% of patients with Buerger's disease, and limited data have recently been published that suggest that these are accompanied by increased cellular sensitivity to human type I or type III collagen, or both.2An immune
Charles James Frederick Maguire
Authors: D. Archer
Journal: BMJ (2010)

<h3>Background</h3> Patients with ROHHAD are usually reported to be healthy prior to a characteristic rapid weight gain associated with autonomic and hypothalamic dysfunction and fatal central hypoventilation in the absence of mutations in the paired-like homeobox 2B (PHOX2B) gene. To our knowledge, this is the first case series report of ROHAAD syndrome from Saudi Arabia comprising four children with different clinical manifestations. <h3>Aims and Objectives</h3> To establish diagnostic pathway for patients with ROHHAD in Saudi Arabia To establish services suited to the needs of this population To educate physicians about early recognition, referral to expert service and instigate prompt management pathway. <h3>Methods</h3> This was a prospective analysis of cases referred from all over Saudi Arabia to our center. The patients were picked up by our sleep service and evaluated by our inpatient and outpatient’s department. <h3>Results</h3> <h3>Conclusions</h3> Early recognition by the clinician of a child with rapid, dramatic weight gain and investigations for hypothalamic dysfunction, hypo-ventilation, autonomic dysfunction and tumours of neural crest origin are critical in achieving a diagnosis of ROHHAD syndrome; however, this is complicated by the overlap with other well-characterised disease entities. Multidisciplinary care with input from a centre with expertise in ROHHAD is crucial to the successful management of these patients. Mortality associated with the high incidence of cardiopulmonary arrest may be prevented by early ventilatory support. <h3>References</h3> Ize-Ludlow DI, Gray JA, et al. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood. <i>Pediatrics</i> 2007;120:e179–88. Rand CM, Patwari PP, Rodikova, et al. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation: analysis of hypothalamic and autonomic candidate genes. <i>Pediatr Res</i>. 2011; 70:375–8. Bougneres P, Pantalone L, et al. Endocrine manifestations of the rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, and neural tumor syndrome. <i>J Clin Endocrinol Metab</i>. 2008; 93:3971–80.