tbuckley/cabot-search huggingface dataset:
The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma
Authors: Teeara Berry, William Luther, Namrata Bhatnagar, Yann Jamin, Evon Poon, Takaomi Sanda, Desheng Pei, Bandana Sharma, Winston R. Vetharoy, Albert Hallsworth, Zai Ahmad, Karen Barker, Lisa Moreau, Hannah Webber, Wenchao Wang, Qingsong Liu, Antonio Perez-Atayde, Scott Rodig, Nai-Kong Cheung, Florence Raynaud, Bengt Hallberg, Simon P. Robinson, Nathanael S. Gray, Andrew D.J. Pearson, Suzanne A. Eccles, Louis Chesler, Rani E. George
Journal: Cancer Cell (2012)
Effects of Famciclovir in Acute Herpes Zoster
Authors: Stephen K. Tyring
Journal: Annals of Internal Medicine (1996)

Letters15 April 1996Effects of Famciclovir in Acute Herpes ZosterStephen K. Tyring, MD, PhDStephen K. Tyring, MD, PhDUniversity of Texas Medical Branch; Galveston, TX 77555Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-8-199604150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The investigators and the institutional review boards of the 36 participating centers in the United States, Canada, and Australia considered the study design to be both ethical and acceptable. Our first patient received study medication in November 1990, shortly after acyclovir had been approved for the short-term treatment of herpes zoster without documented effect on postherpetic neuralgia (April 1990). In contrast, as stated in our report, famciclovir significantly reduced the time to resolution of postherpetic neuralgia (a prospectively defined end point) in the overall sample, as well as in patients 50 years of age or older, who are ... Author, Article, and Disclosure InformationAuthors: Stephen K. Tyring, MD, PhDAffiliations: University of Texas Medical Branch; Galveston, TX 77555 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOrally Active Aminopeptidase A Inhibitors Reduce Blood PressureBrain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: A potential treatment of salt-dependent hypertension 15 April 1996Volume 124, Issue 8 Page: 775 Keywords Institutional review boards Risk management ePublished: 15 August 2000 Issue Published: 15 April 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Lesson in Poverty
Authors: Ananya Das
Journal: Annals of Internal Medicine (2002)

On Being a Doctor17 September 2002A Lesson in PovertyAnanya Das, MDAnanya Das, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-6-200209170-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Today I started working in the hospital located in the center of a bustling metropolis. As I walked toward the endoscopy suite, I could feel my confidence build. I had been well trained and I was ready. But after training in the United States for 7 years, the decision to come back to India was not an easy one. Most of my Indian friends who had gone to the States for advanced training had opted to stay. I had always wanted to return to India. Almost everyone advised me against leaving the States. Nor was it easy to convince my ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Ananya Das, MD, P. Singhania Research Institute, A 30 Chittaranjan Park, New Delhi, Delhi, India 110019; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Lesson in Poverty Daniel Sijipunda Dube A Lesson in Poverty Samiya Razvi and Mohammad A. Rafey Metrics Cited byA Lesson in PovertySamiya Razvi, MD and Mohammad A. Rafey, MDA Lesson in PovertyDaniel Sijipunda Dube, MD 17 September 2002Volume 137, Issue 6Page: 544KeywordsBile ductsChildrenEndoscopic retrograde cholangiopancreatographyEndoscopyFoodLiverMalariaPancreatitisSedationTropical diseases ePublished: 17 September 2002 Issue Published: 17 September 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Suicide risk after a suicide attempt
Authors: U. Reulbach, S. Bleich
Journal: BMJ (2008)

Is highest in people with bipolar disorder and schizophrenia

Two linked studies explore the risk of non-fatal self harm after discharge from a psychiatric hospital and the factors associated with the risk of suicide after a suicide attempt.1 2 Suicide is one of the 10 leading causes of death worldwide and will represent about 2.4% of the global burden of disease by 2020, with about 1.5 million people dying from suicide each year.3 Making the prevention of suicide a health service and public health priority is justified on medical, ethical, and cost effectiveness grounds.4 5

Previous attempts at suicide increase the risk of suicide 30-40 times.6 A history of deliberate self harm is the strongest predictor of future suicidal behaviour.7 A systematic review found that 16% of patients who attended an accident and …
Discrimination between ventricular and supraventricular tachycardia based on implantable defibrillator stored electrogram analysis
Authors: J.L. Rojo, A. Aronal, A. Figueiras, A. Artés, J. Atmendral, J.L. Sande, J. Osendo, J. Villacastin, M. Ortiz, J.L. Delcan
Journal: Journal of the American College of Cardiology (1998)
Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector
Authors: Bing Lu, Sanjeev Gupta, Howard Federoff
Journal: Hepatology (1995)

A defective amplicon herpes simplex virus-1 (HSV-1) vector, HSVlac, was used to transfer an E. coli lacZ reporter gene into primary hepatocytes. The lacZ gene was driven by the HSV immediate early (IE) 4/5 promoter. Use of the HSVlac vector resulted in highly efficient gene transfer. Because difficulties in culturing primary hepatocytes impose limitations in ex vivo gene therapy, we sought to determine whether use of the HSVlac vector could simplify gene transfer. Therefore, we incubated HSVlac with primary hepatocytes in suspension and found that the lacZ gene was still transferred with great rapidity and efficiency. To examine lacZ expression in transduced hepatocytes in vivo, we used a mouse hepatocyte transplantation system. In congeneic recipients of primary hepatocytes transduced with HSVlac in suspension, the lacZ gene was expressed in liver and spleen up to 2 weeks. However, survival of transplanted hepatocytes, as well as persistence of HSVlac genome in recipient organs, was demonstrated for up to an 11-week duration of the experiment. These findings suggest that in vivo regulation of the HSV IE4/5 promoter was responsible for the short-term expression of lacZ, which should be overcome by the use of liver-specific promoters. Therefore, our results indicate the feasibility of hepatic gene transfer with a defective HSV-1 vector.
P94 Patient Agenda Setting And Clinic Efficiency In Outpatients: An Individual Randomised Controlled Trial
Authors: A. Everden, F. Early, K. Homan, J. Fuld
Journal: Thorax (2014)

<h3>Introduction</h3> Most patients have issues to raise in a consultation but may not actually raise them, adversely affecting the consultation outcome. Evidence suggests that methods to help patients consider their information needs before a consultation can increase satisfaction without increasing consultation length but there is a need to assess a wider range of outcome measures and to measure consultation length accurately. We studied the impact of a paper agenda form to prompt question asking in a respiratory outpatient clinic. The primary objective was to identify whether this increased agreement that “My doctor discussed the issues that were important to me”. Secondary endpoints included consultation length and post-consultation confidence to self-manage (0–10 scale). <h3>Method</h3> Patients were randomised to receive the agenda form or usual care by blocked randomization (block size 6), stratified by consultant. Patients receiving the form had a written brief inviting them to complete it in the waiting room. PROMs were collected post-consultation. Consultations were timed by an observer outside the room. As planned in the protocol, categorical data were analysed using Fisher’s exact test and continuous data were analysed using a t-test. Exploratory analyses to assess the effects of a number of factors used mixed model ANOVA. <h3>Results</h3> Groups were well matched at baseline for age, gender and respiratory diagnosis. There was no significant effect of agenda form use on the primary or secondary endpoints (Table 1). Exploratory analyses identified that in new patients (but not in follow-up patients) the form was associated with shorter consultation length (LS mean=15.2 mins) than usual care (LS mean=21.3 mins) (p = 0.017) and with lower confidence to self-manage (LS mean=6.6) than usual care (LS mean=9.2) (p = 0.001). <h3>Conclusion</h3> There was no overall benefit from the form and a risk of detrimental impact on patient experience for some patients. This resonates with reports from other more complex self-management interventions that have found unexpected detrimental effects in some patients. There is a need for greater understanding of what works for whom with regard to self-management support. It cannot be assumed that the impact will be universally beneficial at best or neutral at worst. <h3>Reference</h3> Trial reference: REC reference: 13/WA/0171
Chlorpropamide and an Antabuse-like Reaction
Authors: Susan D. Wolfsthal, Thomas H. Wiser
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 July 1985Chlorpropamide and an Antabuse-like ReactionSUSAN D. WOLFSTHAL, M.D., THOMAS H. WISER, Pharm.D.SUSAN D. WOLFSTHAL, M.D.Search for more papers by this author, THOMAS H. WISER, Pharm.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-1-158_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The editorial by Kreisberg (1) on the use of second-generation sulfonylureas stated that the possibility of an "antabuse-like" reaction and other "adverse side effects may justify selecting a second-generation drug over a first generation drug. " Our recent experience with a patient strongly supports this suggestion.A 31-year-old white woman was treated for management of diabetes mellitus. The patient was in good health until 1982, when she had surgical excision of pedal neuromas. Her fasting blood glucose level was 210 mg/dL and she was begun on chloropropamide, 250 mg/d, after an unsuccessful dietary intervention. In March 1983...References1. KREISBERG R. The second-generation sulfonylureas: change or progress [Editorial]? Ann Intern Med. 1985;102:125-6. LinkGoogle Scholar2. SIGNORELLI S. Tolerance for alcohol in patients on chlorpropamide. Ann NY Acad Sci. 1959;74:900-3. CrossrefMedlineGoogle Scholar3. FITZGERALDGADDIEMALINSO'SULLIVAN MRJD. Alcohol sensitivity in diabetics receiving chlorpropamide. Diabetes. 1962;11:40-3. MedlineGoogle Scholar4. OSTMAN J. Worldwide clinical experience with glipizide: an overview. In: Glipizide: A Worldwide Review. Princeton, New Jersey: Excerpta Medica; 1984. Google Scholar5. FREDERIKSENMORGENSEN PE. A clinical comparison between glipizide (Glibenase) and glibenclamide (Daonil) in the treatment of maturity-onset diabetes: a controlled double-blind crossover study. Curr Ther Res. 1982;32:1-6. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHepatotoxicity of Cardiovascular and Antidiabetic DrugsEffects of Specific Foods and Dietary Components on Drug MetabolismEffects of Specific Foods and Non-Nutritive Dietary Components on Drug MetabolismAlcohol: Gastrointestinal and other ToxicitiesDiabetes MellitusAlternate DrugsInsulin, glucagon and oral hypoglycemic drugs 1 July 1985Volume 103, Issue 1Page: 158-158KeywordsAdverse reactionsBloodDiabetes mellitusGlucose Issue Published: 1 July 1985 PDF DownloadLoading ...
581 A VARIANT IN MICRORNA-196A2 IS ASSOCIATED WITH SUSCEPTIBILITY TO HEPATOCELLULAR CARCINOMA IN MALE CHINESE PATIENTS WITH CHRONIC HEPATITIS B VIRUS INFECTION
Authors: P. Qi, T.-H. Dou, F.-G. Zhou, X. Gu, H. Wang, C.-F. Gao
Journal: Journal of Hepatology (2010)
Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
Authors: John H. Stone, Peter A. Merkel, Robert Spiera, Philip Seo, Carol A. Langford, Gary S. Hoffman, Cees G.M. Kallenberg, E. William St. Clair, Anthony Turkiewicz, Nadia K. Tchao, Lisa Webber, Linna Ding, Lourdes P. Sejismundo, Kathleen Mieras, David Weitzenkamp, David Ikle, Vicki Seyfert-Margolis, Mark Mueller, Paul Brunetta, Nancy B. Allen, Fernando C. Fervenza, Duvuru Geetha, Karina A. Keogh, Eugene Y. Kissin, Paul A. Monach, Tobias Peikert, Coen Stegeman, Steven R. Ytterberg, Ulrich Specks
Journal: New England Journal of Medicine (2010)

Cyclophosphamide and glucocorticoids have been the cornerstone of remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis for 40 years. Uncontrolled studies suggest that rituximab is effective and may be safer than a cyclophosphamide-based regimen.
568 Efficacy and safety of the treatment with peginterferon alpha-2a (PEGASYS®) plus ribavirin in patients with chronic hepatitis C genotype 4: Interim results
Authors: M. Diago, J. Boadas, R. Planasi, R. Solá, J.A. del Olmo, J. Crespo, J.C. Erdozaid, M.D. Antón
Journal: Journal of Hepatology (2006)
Is this what we really want?
Authors: J. Harrison
Journal: BMJ (1996)

Consultants now arrive at their destinations clutching shiny certificates of completion of specialist training (CCST). General practitioners still continue to emerge from vocational training schemes. Yet to speak of having a vocation in today's postmodern world is risky; some might say anachronistic. Just before his death the iconoclast playwright Dennis Potter, in an interview with Melvyn Bragg, mentioned his own sense of vocation as a writer. He lamented that the very word, derived as it was from religious language, seemed ill at ease in our secular world.

In a previous era another troublemaker, the great Protestant reformer, Martin Luther, struggled to liberate the idea of vocation from its strictly monastic context. For him, there was more to life than becoming a monk. To have a calling or “station” in life was a God given privilege, endowed with honour and responsibility. Whether you …
Cell-intrinsic role for IFN-α–STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response
Authors: Haiyan S. Li, Alexander Gelbard, Gustavo J. Martinez, Eiji Esashi, Huiyuan Zhang, Hoainam Nguyen-Jackson, Yong-Jun Liu, Willem W. Overwijk, Stephanie S. Watowich
Journal: Blood (2011)
<i>Helicobacter pylori</i> and gastro-oesophageal reflux disease: Important data were not presented
Authors: Ian L P Beales
Journal: BMJ (2004)

EDITOR—The paper by Harvey at al shows several inconsistencies.1 The first line contains an error: most patients with Helicobacter pylori actually have a mild pangastritis with normal or decreased intragastric acidity; the antral inflammation stimulates hypergastrinaemia but is balanced by a relative suppression of acid secretion by the oxyntic body, …
Endothelial Factors and Diabetic Nephropathy
Authors: Janaka Karalliedde, Luigi Gnudi
Journal: Diabetes Care (2011)

The rising incidence and prevalence of chronic kidney disease (CKD) (glomerular filtration rate <60 mL/min per 1.73 m2) is a major public health concern (U.S. Renal Data System 2010, http://www.usrds.org). Hypertension is the second leading cause of end-stage renal disease (ESRD) in the U.S. and is also a major contributor to diabetic renal disease, which is the leading cause of CKD and ESRD (U.S. Renal Data System 2010). The diabetes-related ESRD annual incidence rate has been decreasing since 1996, suggesting that the net increase in diabetes-related ESRD may be secondary to the documented pandemic of type 2 diabetes (1,2).

In the general population, CKD predicts death and cardiovascular disease (CVD) events, independently of traditional cardiovascular risk factors such as age, sex, prior CVD, diabetes, hypertension, dyslipidemia, and proteinuria (3). CKD in patients with type 2 diabetes is independently associated with an ∼8–10% annual absolute risk for death and CVD (4). The majority of patients with CKD will die of a CVD event before they reach end-stage renal failure and dialysis treatment (5), and an estimated glomerular filtration rate <60 mL/min is now classified as a major independent risk factor for CVD.

Endothelial dysfunction has been implicated as a potential major mechanism for renal chronic microvascular complications both in diabetic and nondiabetic patients with albuminuria. There is a general assumption of a final common biological pathway that results in diabetic kidney disease and renal failure. As shown in Fig. 1, hyperglycemia and hypertension interact at the glomerulus, resulting in glomerular hypertension and, as a consequence, proteinuria, glomerular and interstitial tissue fibrosis (6), progressive decline in glomerular filtration rate, and finally renal failure.



Figure 1 
Principal mechanisms of diabetic glomerulopathy. Hyperglycemia and hypertension interact at the glomerulus, resulting in glomerular hypertension, progressive glomerular and interstitial tissue fibrosis, and decline …
Functional and neurochemical evidence for partial cardiac sympathetic reinnervation after cardiac transplantation in humans.
Authors: D M Kaye, M Esler, B Kingwell, G McPherson, D Esmore, G Jennings
Journal: Circulation (1993)

The presence of cardiac reinnervation in humans after cardiac transplantation has been widely debated, based on the application of differing methods for the assessment of neuronal function. Some of these techniques have been rather indirect; consequently, the time course and extent of cardiac reinnervation remains uncertain.To test for the presence of cardiac reinnervation after transplantation, we examined neurochemical (radiolabeled norepinephrine [NE] kinetics) and functional markers (power spectral analysis, heart rate response to exercise) of cardiac sympathetic nerve integrity in 15 cardiac transplantation recipients and 25 healthy control subjects of similar age. Cardiac transplantation subjects were studied 9 weeks to 8 years after cardiac transplantation (10 "early" patients < 18 months and 5 "late" patients > 2 years after cardiac transplantation). At rest, cardiac NE spillover was markedly attenuated early after transplantation (11.2 +/- 18.3 pmol/min) compared with subjects late after transplantation (105 +/- 11 pmol/min, P < .01) or in healthy control subjects (103 +/- 15 pmol/min, P < .01). Heart rate variability (measured by total spectral power) was significantly reduced in cardiac transplantation recipients compared with control subjects (59.4 +/- 30 vs 1673 +/- 516 milliseconds squared; P < .05), with evidence of a trend toward increasing spectral power late after transplantation. During exercise, the cardiac NE spillover was significantly lower in early cardiac transplantation recipients when compared with control subjects (163 +/- 50 vs 1876 +/- 418 pmol/min, P < .01). Late cardiac transplantation subjects showed a response intermediate (1080 +/- 254 pmol/min) between that of the early cardiac transplantation and control groups. However, measurements of the neuronal reuptake process for NE (assessed by the fractional extraction of plasma labeled NE across the heart and tritiated dihydroxyphenylglycol release) were significantly depressed in both early and late cardiac transplantation subjects.The present study demonstrates a partial restoration of cardiac sympathetic nerve function in humans up to 8 years after heart transplantation.
Bateman domains and adenosine derivatives form a binding contract
Authors: Bruce E. Kemp
Journal: Journal of Clinical Investigation (2004)

Conserved pairs of CBS sequence motifs (named after cystathionine β-synthase) found in a wide variety of proteins associate to form Bateman domains. A new study establishes that Bateman domains bind adenosyl compounds and regulate IMP dehydrogenase, CBS, chloride channels, and AMP-activated protein kinase. This discovery reveals how mutations in CBS sequences in these proteins cause hereditary diseases and provides a rich vista of conceptual opportunities for therapies in energy metabolism, obesity, diabetes, cancer, antivirals, and immunosuppression.
The Signs and Symptoms of Impending Death
Authors: Thomas F Reilly
Journal: JAMA (2016)

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Dose-proportional pharmacokinetics of terbinafine and its N-demethylated metabolite in healthy volunteers
Authors: J.M. KOVARIK, S. KIRKESSELI, H. HUMBERT, P. GRASS, K. KUTZ
Journal: British Journal of Dermatology (1992)

The dose‐dependency of the pharmacokinetic parameters of terbinafine and its N‐demethyl derivative was investigated in a randomized four‐way crossover study in healthy volunteers following single oral administrations of 125, 250, 500 and 750 mg of terbinafine. Plasma concentrations of terbinafine and its metabolite were measured by a validated high‐performance liquid chromatography (HPLC) method using ultraviolet detection. Concentration data were fitted to a two‐compartment model. The relationship between Cmax or the area under the concentration curve (AUC) and the terbinafine dose was analysed by classical linear regression. Terbinafine disposition parameters were dose‐independent, with the exception of Tmax and t1/2x, which were prolonged with the 500‐ and 750‐mg doses. The terbinafine Cmax and AUC, however, were linear and dose‐proportional over the entire dose range. The N‐demethylated metabolite appeared in plasma at the same time as terbinafine and showed similar prolongations in Tmax and t1/2x with the 500‐ and 750‐mg doses. In addition, the Cmax deviated from proportionality at these doses, giving values 22% lower than projected, while the AUC was linear and dose‐proportional over the whole range of doses. The slight disproportionality in the dispositions of terbinafine and its N‐demethyl metabolite at 500 and 750 mg are not expected to be clinically significant.