tbuckley/cabot-search huggingface dataset:
Abstract 2577: Blocking Janus activated kinase-2 activation by DIM suppresses ovarian tumor growth <i>in vitro</i> and <i>in vivo</i>
Authors: Prabodh K. Kandala, Sanjay K. Srivastava
Journal: Cancer Research (2012)

Abstract Ovarian cancer is one of the leading causes of gynecological deaths in the United States and several other countries. Genetic alterations including overexpression of EGFR and STAT-3 play a crucial role in the signal transduction pathways that regulate key cellular functions such as cell survival, proliferation, metastases etc. Several epidemiological studies suggested a decreased risk of ovarian cancer in the population consuming Brassica vegetables. 3,3′-diindolylmethane (DIM) is an indole compound present in Brassica vegetables. In our previous studies, we have demonstrated that DIM induces apoptosis in ovarian cancer cells by inhibiting the activation STAT-3. However, the exact mechanism of STAT-3 regulation by DIM was not clear. Accumulating evidences suggest that Janus Activated Kinases (JAK's) play a crucial role in regulating STAT-3. Our current results show that DIM inhibits the activation of JAK-2 by blocking its phosphorylation at Tyr-1007/1008 in a concentration-dependent manner in SKOV-3 and OVCAR-3 cells. Inhibition of JAK-2 phosphorylation by DIM was as early as one hour after DIM treatment. The expression of survivin was significantly reduced by DIM. IL-3 is a cytokine that specifically activates JAK-2. Treatment of SKOV-3 or OVCAR-3 cells with 10ng/ml IL-3 for 15min not only increased the activation of JAK-2 and STAT-3, but also induced the expression of STAT-3. DIM treatment almost completely blocked IL-3 induced phosphorylation of JAK-2 and STAT-3 in SKOV-3 and OVCAR-3 cells. Several studies have shown that JAK's are regulated by EGFR, hence to test this, cells were stimulated with EGF, a specific ligand of EGFR. As expected, EGF treatment increased the activation of JAK-2 and STAT-3 in SKOV-3 cells. Nonetheless, DIM treatment blocked the phosphorylation of JAK-2 and STAT-3 induced by EGF. Furthermore, our in vivo studies demonstrated that oral administration of 3 mg DIM for 40 days significantly suppressed the growth of ovarian tumors xenografts in athymic nude mice. The tumors of DIM treated mice exhibited reduced phosphorylation of JAK-2, EGFR and STAT-3 and increased apoptosis. These results indicate that DIM induces apoptosis in ovarian tumor cells by regulating JAK-2 activation in vitro and in vivo. [Supported in part by R01 grants CA 106953 and CA 129038 awarded to S.K.S by National Cancer Institute, NIH] Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2577. doi:1538-7445.AM2012-2577
The RANKL/OPG system and bone mineral density in patients with chronic liver disease
Authors: Alexander R. Moschen, Arthur Kaser, Sylvia Stadlmann, Gunda Millonig, Susanne Kaser, Petra Mühllechner, Andrzej Habior, Ivo Graziadei, Wolfgang Vogel, Herbert Tilg
Journal: Journal of Hepatology (2005)
Abstract 5175: Re-analysis of breast invasive carcinoma (BRCA) TCGA copy number data improves tumor profiles
Authors: Louis J. Culot, Andrea O'Hara, Raja Keshavan, Zhiwei Che, Soheil Shams
Journal: Cancer Research (2014)

Abstract Using the copy number and SNP- probes available in the TCGA level 1 data, reprocessed tumor profiles were more consistent with a control set in terms of median number of copy number events, sample ploidy, and breakpoint genes than the published “level 3” TCGA data. Probe-level data were analyzed using Nexus Copy Number SNP-FASST2 (a multi-state HMM algorithm that uses both SNP and copy number probes in making state assignments), with systematic correction applied to correct for GC biases. Additionally we performed manual baseline adjustment to correct for sample ploidy based on whole-genome B-alelle frequency data for each sample. The median number of copy number events in the TCGA data set was reduced from 377 (in the level 3 set) to 193, with a corresponding reduction in variance, and in line with our control samples (median CN changes of 173 and 142). After manual inspection, more than 15% of the TCGA BRCA samples available at level 3 were found to have incorrect baseline ploidy assignments. The resultant reanalyzed data set, along with associated clinical annotations for each sample, is available through Nexus DB repository to the general scientific community and should provide greater utility for further research. Citation Format: Louis J. Culot, Andrea O'Hara, Raja Keshavan, Zhiwei Che, Soheil Shams. Re-analysis of breast invasive carcinoma (BRCA) TCGA copy number data improves tumor profiles. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5175. doi:10.1158/1538-7445.AM2014-5175
A NEW INSTRUMENT IN SPLANCHNIC ANESTHESIA
Authors: Peyton R. Denman
Journal: JAMA (1925)

In performing splanchnic anesthesia, especially in cases in which many adhesions are encountered, I found it most difficult to introduce the needle, and frequently imposible.  In order to facilitate this procedure and to introduce the anesthetic solution successfully in practically all cases, I had an instrument made that makes the introduction possible and safe.  The instrument consists of a 7 inch needle fitted into a sleeve, which will engage and disengage the point of the needle by a simple rotation of either the sleeve or the needle.  Tissue Culture.  —The restraining action of serum on cell multiplication becomes more pronounced after the serum has been shaken for one hour or more, or subjected to the action of heat at 65 C. for thirty minutes.—Alexis Carrel.
Government orders inquiry as price of generic drugs soars
Authors: J. Jones
Journal: BMJ (1999)

An inquiry into the generic drugs market has been ordered by the UK government amid evidence that some non-branded drugs now cost seven times the prices charged a year ago.

In the past year, the antibiotic amoxicillin, for example, has risen from 47p ($0.75) to £1.69 for a 250 mg pack of tablets. A 100 mg pack of thyroxine has gone up in price from 21p to £1.62, and a 40 mg pack of the diuretic frusemide (furosemide) costs £2.14, compared with 26p in September …
Recent Progress in Human Transplantation Immunology
Authors: JOHN L. FAHEY
Journal: Annals of Internal Medicine (1969)

The present status of organ transplantation in man is reviewed. Immune rejection of the graft (the homograft reaction) remains a central problem in transplantation immunology. Efforts to control the homograft reaction include tissue typing to identify the significant transplantation antigens as well as suppression of immune reactivity. A new approach to specific immune suppression is the use of soluble transplantation antigens to induce specific tolerance. Human and mouse transplantation antigens have been prepared in soluble forms and are being characterized chemically and biologically. In bone marrow transplantation the immune reaction of graft against the host—which does not occur in most organ transplants—is an area of special concern. On the other hand, transplantation of bone marrow and related lymphoid tissue does offer opportunities for supplying immune competence that may be useful in treatment of cancer.
Interactions between influenza and bacterial respiratory pathogens: implications for pandemic preparedness
Authors: John F Brundage
Journal: The Lancet Infectious Diseases (2006)

It is commonly believed that the clinical and epidemiological characteristics of the next influenza pandemic will mimic those of the 1918 pandemic. Determinative beliefs regarding the 1918 pandemic include that infections were expressed as primary viral pneumonias and/or acute respiratory distress syndrome, that pandemic-related deaths were the end states of the natural progression of disease caused by the pandemic strain, and that bacterial superinfections caused relatively fewer deaths in 1918 than in subsequent pandemics. In turn, response plans are focused on developing and/or increasing inventories of a strain-specific vaccine, antivirals, intensive care beds, mechanical ventilators, and so on. Yet, there is strong and consistent evidence of epidemiologically and clinically important interactions between influenza and secondary bacterial respiratory pathogens, including during the 1918 pandemic. Countermeasures (eg, vaccination against pneumococcal and meningococcal disease before a pandemic; mass uses of antibiotic(s) with broad spectrums of activity against common bacterial respiratory pathogens during local epidemics) designed to prevent or mitigate the effects of influenza-bacterial interactions should be major focuses of pandemic-related research, prevention, and response planning.
Comparisons of Safety-Net and Non–Safety-Net Hospitals
Authors: Gene Marie O’Connell
Journal: JAMA (2008)

To the Editor: In their study of safety-net and non–safety-net hospitals, Dr Werner and colleagues1 assert that both quality of care and the rate of improvement in safety-net hospitals are lower than in non–safety-net hospitals. I believe there are flaws in the study methodology and findings.
Anaesthetists need consent, but not written consent
Authors: A. Aitkenhead
Journal: BMJ (1999)

EDITOR—Dobson's article concerning information and consent for anaesthesia appeared under the headline “Anaesthetists do not need separate consent before surgery,” and stated that “New guidelines on obtaining consent for anaesthesia recommend that consent from patients specifically for a general anaesthetic is not needed.”1 These statements are incorrect, and I believe that they may mislead readers.

The guidelines issued by the …
A CASE OF RODENT ULCER PRESENTING SOME UNUSUAL FEATURES
Authors: R. Farrant
Journal: BMJ (1911)

frolmi two large ulcers, onie uinider the right eve. the otlher onl the nose.The onie oni the niose had eateln its way through the cartilage, left nasal fossa, and tissues, exposing tlle boine.It was about ani inchi in lenigth an-(d in brea,dth, extended right across tlhe bridge, leaving the tip of the niose almost (letaclied.The ulcer oni the cheek, unider the riglt eye.which unforttu- iiately does iiot slhow up in the photogralplh, was about an inch in lenigtlh aiid about olne aind a haltf incies in breadth.Botlh nlcers looked ulihealthy, and were diselhargiiig freely.I applied thlree tubes of ra(lium, containing 250 mng., eacll tube beilng screene(d witlh 2' mm. of platinium, onie oIn each side of the niose, atnd the otlher oni the ulcer unider the e e, having previously
Understanding the Germicidal Effects of Silver Nanoparticles
Authors: Carol Potera
Journal: Environmental Health Perspectives (2012)

Understanding the Germicidal effects of silver NanoparticlesSilver nanoparticles are an effective tool for killing disease-causing bacteria.But despite their widespread use in catheters, clothing, toys, cosmetics, and many other products, 1 investigators haven't fully understood whether their effectiveness is a function of the release of germicidal silver ions, some feature specific to their nanoparticle form, or both.Researchers at Rice University now report evidence that the release of dissolved silver ions is the driving force behind silver nanoparticles' germicidal action. 2
Brian Rowland Griffiths
Authors: W. Lewis
Journal: BMJ (2003)

Former general practitioner Blaenavon, Torfaen, south Wales (b 1933; q Welsh School of Medicine 1959), died from coronary artery thrombosis on 27 January 2003.​2003.




Figure 1




Brian worked as a full time GP partner in Blaenavon until his retirement in 1994, after which he did locum work. He leaves a wife, Margaret, and two sons.
An Address on the Clinical and Therapeutical Aspects of Influenza--From 1889 to 1927: The Value of Salicin in Treatment
Authors: E. B. Turner
Journal: BMJ (1927)

DTCLBN 93 ms full to-day as it was in the days of Lacunec and Bright of opportunities for eniduring contributionis to science and to humanity.This spirit Bright carr ied with him throughout his ca.reer.He could not have beeni called a brilliant man.Lie inade at first no great imilression on those abotut hliim.But b illiancy is often ephemeral; very often brillianey spells instability.Bright showed a steadfastness of pl)OulSP and an equanimity that are rarer antdl more lprecious thlan mere brilliancy.He was a simple, straightforward, kindly man, wlio imlet life with charity and toler-ance anad serenity- a conscientious, painstaking physiciani; a patient, careful, modest, scrupulous, tim-le-taking observer.He be anine a wise anid a learned mlian, and the fruits of his labours assure him a well merited and hionourable immortality.Bright was buried in Kensal Greeni.There is a tablet dedicated to his memory in St. James's Church in Piccadilly.
371 PLASMA HOMOCYSTEINE AND METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) C677T POLIMORPHYSM IN BRAZILIAN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: S.R. Carvalho, M.T. Muniz, E.R. Siqueira, K.A. Silva, F.S. Silva, L.C. Bezerra, V.D. Almeida, C.M. Oliveira, L.M. Pereira
Journal: Journal of Hepatology (2010)
Correction of severe hyponatraemia by continuous arteriovenous haemofiltration before liver transplantation.
Authors: A. J. Larner, C. R. Vickers, D. Adu, J. A. Buckels, E. Elias, J. Neuberger
Journal: BMJ (1988)

2 observations. Resultats satisfaisants 10 et 13 mois apres la transplantation (chez des femmes adultes)
Navigating through the gray (and CMYK) areas of figure manipulation: rules at the JCI
Authors: Ushma Neill, Laurence A. Turka
Journal: Journal of Clinical Investigation (2007)

Since it seems many of the articles we’re accepting continue to have image rearrangements and changes in them that are not consistent with JCI policy, we thought it might be a good idea to spell out exactly what is, and more importantly what isn’t, allowed.
Lyso-Phosphatidylserine (Lyso-ps) Generated by Activated Neutrophils Signals in an Autocrine/paracrine Manner Via G2a- And Rho-dependent Pathways
Authors: D.L. Bratton, S.C. Frasch, K. Zemski-Berry, M. Fessler, C. Shearn, R.C. Murphy, P.M. Henson
Journal: Journal of Allergy and Clinical Immunology (2006)
A multichannel information-processing system is simpler and more easily tested
Authors: Thomas R. Zentall
Journal: Behavioral and Brain Sciences (2002)

The dance metaphor for the communication between two organisms may be an appealing image because it appears to capture the intricate synchronization of their interaction; however, it is neither parsimonious nor easily tested. Instead, a multichannel information-processing model, even one that can process only serial events, provides all of the flexibility required to account for the complex temporal coordinated action observed.
Primary Hyperparathyroidism and Basal Cell Nevus Syndrome
Authors: AHMAD FATHIZADEH
Journal: Annals of Internal Medicine (1980)

Letters1 July 1980Primary Hyperparathyroidism and Basal Cell Nevus SyndromeAHMAD FATHIZADEH, M.D., DAVID F. FRETZIN, M.D., MURRAY J. FAVUS, M.D., FREDERIC L. COE, M.D.AHMAD FATHIZADEH, M.D.Search for more papers by this author, DAVID F. FRETZIN, M.D.Search for more papers by this author, MURRAY J. FAVUS, M.D.Search for more papers by this author, FREDERIC L. COE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-147_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the basal cell nevus syndrome, an autosomal dominant trait with high penetrance and variable expressivity, numerous basal cell epitheliomas appear during the second and third decades accompanied by keratocysts of the jaw, bifid ribs, brachymetacarpalism, frontal and temporoparietal bossing, hypertelorism, and areas of ectopic calcification (1, 2). Other features include palmar and plantar pits, hirsutism, epidermal cysts, oculoneurologic abnormalities, gastric hamartomatous polyps, mesenteric cysts, and ovarian teratoma. The syndrome has been associated with uterine and ovarian fibroma, cystadenoma and theca cell tumors, meduloblastoma, multiple meningiomas, astrocytomas, ameloblastomas, craniopharyngioma, and fibrosarcoma of the jaw. We report here...References1. NOMLAND R. Multiple basal cell epitheliomas originating from congenital pigmented basal cell nevi. Arch Dermatol Syphilol. 1932;25:1002-8. CrossrefGoogle Scholar2. HOWELCARO JM. The basal cell nevus. Arch Dermatol. 1959;79:67-80. Google Scholar3. GORLINYUNISTUNA RJN. Multiple nevoid basal cell carcinoma, odontogenic keratocyst and skeletal anomalies: a syndrome. Acta Derm Venereol (Stockh). 1963;43:39-55. MedlineGoogle Scholar4. KAUFMANCHASE RL. Basal cell nevus syndrome: normal responsiveness to parathyroid hormone. Birth Defects. 1971;7:149-55. MedlineGoogle Scholar5. BOONSTRAJACKSON CC. Serum calcium survey for hyperparathyroidism; results in 50,000 clinic patients. Am J Clin Pathol. 1971;55:523-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Michael Reese Hospital and Medical Center Chicago, IL 60616 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNevoid Basal Cell Carcinomata Mimicking Melanocytic Nevi: Case ReportThyroid Cancer Detection with Dual-isotope Parathyroid Scintigraphy in Primary Hyperparathyroidism 1 July 1980Volume 93, Issue 1_Part_1Page: 147-147KeywordsAstrocytomaAutosomal dominant traitsBasal cell carcinomasBasal cellsHyperparathyroidismRibs ePublished: 1 December 2008 Issue Published: 1 July 1980 PDF downloadLoading ...
Financing a Medical-Care Program through Social Security
Authors: Osler L. Peterson
Journal: New England Journal of Medicine (1961)

THE national debate on government aid to help old people meet their medical bills has shifted ground since Congressman Forand first raised the issue several years ago. The support now given the Kerr—Mills legislation apparently is recognition that old people have special problems in paying for medical care that require government action. The debate is now concentrated on the question of an amplified welfare program or the use of social security to meet this financial problem.Inevitably, this debate has at times become confused and its logic disorderly. Arguments about whether social security is insurance or whether a given backward . . .
Vulnerable plaque diagnosis by a self-contained intravascular magnetic resonance imaging probe in Ex vivo human insitu coronary arteries
Authors: Jacob Schneiderman, Robert L. Wilensky, Assaf Weisse, Eitzik Samouha, Lev Muchnik, Gil Alexandrowicz, Malca Chen-Zion, Mordechay T. Ilovich, Moshe Flugeiman, Erez Golan, Renu Virmani
Journal: Journal of the American College of Cardiology (2003)
Treating Problem Children with Stimulant Drugs
Authors: L. Alan Sroufe, Mark A. Stewart
Journal: New England Journal of Medicine (1973)

MORE than 150,000 children with behavior or learning problems are now being treated with stimulant drugs, with the number apparently increasing rapidly as proposals for massive screening begin to appear.1 2 3 4 5 Since the prevalence of hyperactivity is about 5 per cent of children in elementary school,6 and that of specific reading disability 3 per cent,7 there is a very large population of children who might be treated in this way. We believe that the use of stimulant drugs should be critically appraised before society moves farther in this direction.The literature on the short-term effects of stimulant medication with problem children . . .
Penicillin‐induced immunohemolytic anemia associated with circulating immune complexes
Authors: T. Funicella, R. S. Weinger, J. L. Moake, M. Spruell, R. D. Rossen
Journal: American Journal of Hematology (1977)

Abstract Eleven days after administration of multiple penicillin analogs, a 55‐year‐old female developed a Coombs‐positive hemolytic anemia. The patient's erythrocytes were coated with IgG, complement components (C4/C3) and her serum contained elevated 125 I‐Clq binding activity (a measure of the presence of immune complexes). Her serum, in the presence of fresh complement and penicillin, induced complement sensitization of normal erythrocytes. Immune complex‐mediated complement activation and the haptene type of erythrocyte sensitization accounted for accelerated red blood cell destruction in this patient.
Coronary Artery Status of Apparently Healthy Subjects with Frequent and Complex Ventricular Ectopy
Authors: HAROLD L. KENNEDY
Journal: Annals of Internal Medicine (1980)

Twenty-five subjects from a cohort of 62 asymptomatic, apparently healthy subjects incidentally discovered to have frequent and complex ventricular ectopy were studied with cardiac catheterization and coronary angiography. Fourteen had normal coronary arteries, five noncritical coronary artery disease (less than 50% luminal narrowing), and six significant coronary artery disease (greater than or equal to 50% luminal narrowing). Slightly elevated left ventricular end diastolic pressures were found in all subject subgroups. Characteristics of the ventricular ectopy detected by maximal exercise testing or 24-hour Holter ambulatory electrocardiography did not differentiate those subjects with coronary artery disease from those with normal coronary arteries. This study documents that a minority of apparently healthy subjects with frequent and complex ventricular arrhythmia have significant coronary artery disease and supports a conservative approach to the management of such patients.
An improved method for the determination of the pulse transmission characteristics of arteries in vivo.
Authors: R Busse, R D Bauer, A Schabert, Y Summa, E Wetterer
Journal: Circulation Research (1979)

On the basis of the theory of wave transmission lines, an improved method is described which permits the determination of the complex propagation coefficient of arteries from the Fourier components of natural pressure pulses.This coefficient is composed of the damping constant (a) and the phase constant (/?).In the arterial system, there is always a superposition of forward-and backwardtraveling waves, the interrelationship of which is not known to the investigators.Therefore, we have to deal with an additional unknown, and at least three independent measurements are necessary.Previous methods required recordings of three or four variables, such as pressure, flow, and/or diameter.In the new procedure, only two recordings of pressure are needed.This is made possible by occluding the artery directly behind the distal measuring point so that total positive reflection occurs and a defined relationship between forward and backward waves is brought about.This method is applied in the common carotid arteries of nine dogs.By the additional recording of the arterial diameter by means of a photoelectric device, the characteristic impedance (Z) is also determined.For the frequency range of 1.25-12 Hz, a was found to increase from 0.003 to 0.01 Neper/cm, and /J from 0.02 to 0.1 radian/cm.The phase velocity was 9-11 m/sec.The modulus of Z was between 7,000 and 12,000 CGS units and dropped slightly with increasing frequency.The results are compared with those of other authors, and the accuracy of the various methods is discussed.
The Thermoelastic Behavior of Isolated Aortic Strips of the Dog
Authors: RICHARD W. LAWTON
Journal: Circulation Research (1954)

A detailed thermodynamic study of isolated strips of dog aorta is basic to the interpretation of the nonlinear and apparently rubber-like elastic behavior of such specimens. Experimental data indicate that the retractile force in isolated aortic strips of the dog is entropic. Volume changes with elongation in such strips are negligible. However, a large negative internal energy contribution to the total force is present at small elongations. Studies of aortic strips extracted with alkali suggest that the latter force arises from the elastic tissue itself.