tbuckley/cabot-search huggingface dataset:
Quantification and validation of left ventricular wall thickening by a three-dimensional volume element magnetic resonance imaging approach.
Authors: R Beyar, E P Shapiro, W L Graves, W J Rogers, W H Guier, G A Carey, R L Soulen, E A Zerhouni, M L Weisfeldt, J L Weiss
Journal: Circulation (1990)

We have developed a method to quantify and map regional wall thickening throughout the left ventricle (LV) with magnetic resonance imaging. In contrast to methods that measure planar wall thickness and thickening, this method uses the three-dimensional (3D) geometry of the left ventricle to calculate the perpendicular thickness of the wall. We tested this method at three levels of increasing complexity using 1) phantom studies, 2) in vivo experiments in dogs with normal cardiac function, and 3) in vivo studies in dogs during acute ischemia. Experiments were conducted in 15 open-chest dogs imaged by a 0.38 T iron core magnet. Five short-axis images at end diastole and end systole were obtained with the spin echo technique by use of the QRS as a trigger for end diastole and the second heart sound, S2, to time end systole. After acquisition of preischemic images, acute ischemia was induced by either coronary artery ligation (n = 5) or intracoronary dental rubber injection (n = 5), which produced severe transmural ischemia. By use of computer-aided contouring of the endocardial and epicardial borders, each image was divided into 16 segments with radial lines originating from the midwall centroid. A 3D volume element was defined as that generated by connecting two matched planar segments in two adjacent image planes. This defined 64 volume elements comprising the entire left ventricle. Thickness and thickening before and during ischemia were then calculated by using the planar segments and the 3D volume elements. In phantom studies, the 3D method was accurate, independent of the angle of inclination of the image plane to the phantom wall, whereas the planar method showed considerable overestimation of thickness when the image plane was oblique to the phantom wall. In the dogs before induction of ischemia, the 3D method demonstrated the well-established normal taper in end-diastolic wall thickness from 1.10 +/- 0.02 cm at the base to 1.05 +/- 0.11 cm at the apex (p less than 0.01). By contrast, the planar method did not detect the decrease in thickness toward the apex (1.13 +/- 0.07 cm at the base vs. 1.16 +/- 0.14 cm at the apex, p = NS). During acute ischemia, thickening was calculated by both methods at the center of the ischemic zone defined by Monastral blue nonstaining and compared with the preischemic values.(ABSTRACT TRUNCATED AT 400 WORDS)
Cervical Toxoplasmic Lymphadenitis can Mimic Malignant Lymphoma on FDG PET
Authors: Yutaka Yamazaki, Yoshimasa Kitagawa, Hironobu Hata, Noriyuki Sakakibara, Masanobu Shindoh, Nagara Tmamaki
Journal: Clinical Nuclear Medicine (2008)

A 63-year-old woman presented with indolent swelling in her right submandibular region. CT and MRI demonstrated enlargement of multiple right neck lymph nodes with homogeneous enhancement. Because malignant lymphoma was suspected, whole body FDG PET was performed, which revealed accumulation of FDG in the submandibular region and additional increased accumulation with delayed imaging. After excisional biopsy of the enlarged right submandibular lymph node, histopathology showed evidence of probable toxoplasmic lymphadenitis. The patient had a history of exposure to cats and her serum toxoplasmic antibody titer was high. These findings led to a final diagnosis of toxoplasmosis. Increased uptake on FDG PET may occur in patients with cervical toxoplasmic lymphadenitis.
Targeting high-risk pediatric solid tumors with CAR T cells directed against ALK (anaplastic lymphoma kinase, CD246)
Authors: Alec Walker, Paola Lopomo, William Babbitt, Marc Vigny, Crystal Mackall, Rimas Orentas
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Neuroblastoma is the most common non-CNS tumor in children. Poor prognosis for patients presenting with high-risk disease underlines the need for novel therapeutic strategies. Chimeric antigen receptor T cell (CART) therapies combine the epitope specificity of a monoclonal
Evaluation of transthoracic electrical impedance in the diagnosis of pulmonary edema.
Authors: A Fein, R F Grossman, J G Jones, P C Goodman, J F Murray
Journal: Circulation (1979)

To evaluate the clinical usefulness of measuring transthoracic electrical impedance in patients with pulmonary edema, we studied 27 normal subjects and 33 patients. In normal subjects, impedance increased when body position changed from supine to standing (p less than 0.01) and when lung volume increased from residual volume to total lung capacity (p less than 0.01). Impedance values vari7 omega) when measured hourly without removing the electrodes. In only five of 11 patients with clinically severe pulmonary edema and five of eight with radiologically severe pulmonary edema were impedance values outside the normal range. Changes in impedance values correlated with changes in clinical and radiographic indexes of pulmonary edema. We conclude that (1) single measurements of impedance are useless in diagnosing pulmonary edema, and (2) impedance changes as predicted as pulmonary edema increases and decreases, and these changes are readily detected by simpler methods of evaluation.
"Pseudophlebitis" and Rheumatoid Arthritis.
Authors: M. C. Schmidt
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971"Pseudophlebitis" and Rheumatoid Arthritis.M. C. Schmidt, M.D., J. B. Workman, M.D., F.A.C.P., W. F. Barth, M.D.M. C. Schmidt, M.D.Search for more papers by this author, J. B. Workman, M.D., F.A.C.P.Search for more papers by this author, W. F. Barth, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-842_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA syndrome of calf pain, tenderness, and local erythema together with ankle edema and a positive Homan's sign occurs in patients with rheumatoid arthritis. The syndrome is secondary to extension, dissection, or rupture of a popliteal cyst into the calf. In many patients an incorrect diagnosis of deep vein thrombophlebitis is made and anticoagulants are used. We have recently seen this syndrome in four patients with rheumatoid arthritis. In two, it was bilateral but not simultaneous. In three patients, the correct diagnosis was established rapidly using scintillation scanning. Twenty to 25 µc (1 ml) of131I human serum albumin were... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 842-842KeywordsAnklesAnticoagulantsEdemaErythemaPainRheumatic painRheumatoid arthritisSerum albuminVeins Issue Published: 1 May 1971 PDF downloadLoading ...
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways
Authors: Chuanhong Wu, Wenwen Zhao, Xuenong Zhang, Xiuping Chen
Journal: Acta Pharmaceutica Sinica B (2015)

Neocryptotanshinone (NCTS) is a natural product isolated from traditional Chinese herb Salvia miltiorrhiza Bunge. In this study, we investigated its anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) cells. MTT results showed that NCTS partly reversed LPS-induced cytotoxicity. Real-time PCR results showed that NCTS suppressed LPS-induced mRNA expression of inflammatory cytokines, including tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and interleukin-1β (IL-1β). Moreover, NCTS could decrease LPS-induced nitric oxide (NO) production. Western blotting results showed that NCTS could down-regulate LPS-induced expression of inducible nitric oxide synthase (iNOS), p-IκBα, p-IKKβ and p-NF-κB p65 without affecting cyclooxygenase-2 (COX-2). In addition, NCTS inhibited LPS-induced p-NF-κB p65 nuclear translocation. In conclusion, these data demonstrated that NCTS showed anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways.
1155-77 Clinical, angiographic, and intravascular ultrasound comparisons between patients with early versus late saphenous vein graft failure
Authors: Daniel Arthur Canos, Gary S Mintz, Jose R Cordero, Esteban Escolar, Jun-Ichi Kotani, Natalie Gevorkian, Augusto D Pichard, Lowell F Satler, Kenneth M Kent, Neil J Weissman
Journal: Journal of the American College of Cardiology (2004)
Where Will Managed Care Fit in Medical Education?-Reply
Authors: David Blumenthal
Journal: JAMA (1997)

<h3>In Reply.</h3> —We certainly agree with Dr Katz that the ambulatory sector of the health care system should be a full partner in the future education of young physicians, as well as in research and patient care generally. If we failed to communicate this viewpoint, we regret it. The reason for any misunderstanding may lie in our decision to address our recommendations for change to the "academic medical center," which connotes in many minds the hospital-oriented educational and scientific institutions that have dominated academic medicine for the last 50 years. Change must begin somewhere, and given where we start in academic medicine today, the academic medical center should logically play a role in reforming medical education, including the development of a vital ambulatory educational enterprise. As for what the ambulatory academic enterprise should look like in 20 years and what precise role community settings ought to play, we can only urge Dr
US has most reports of medical errors
Authors: Barbara Kermode-Scott
Journal: BMJ (2005)

Developed countries around the world urgently need to tackle coordination of care, safety issues, medical errors, and communication in their healthcare systems, a new international survey has found.



The survey, from the Commonwealth Fund, a private foundation supporting independent research on health and social issues, evaluated the experiences of patients in Australia, Canada, Germany, New Zealand, the United States, and the United Kingdom. …
More women drink at hazardous levels in England than Italy
Authors: E. F S Kaner, C. A Haighton, B. R McAvoy, N. Heather, E. Gilvarry
Journal: BMJ (1997)

Editor—Marco Piccinelli and colleagues describe 482 patients who presented to 10 primary care clinics in Italy and completed the alcohol use disorders identification test.1 2 In England we are conducting a randomised controlled trial of methods to encourage the uptake and use by general practitioners of a brief alcohol intervention programme incorporating the alcohol use disorders identification test as its screening questionnaire. We have compared characteristics and drinking behaviour of primary care patients in Italy and England.

In our study 128 general practitioners from northern England (one per practice) agreed to implement a brief intervention programme. …
Transendothelial migration leads to protection from starvation-induced apoptosis in CD34+CD14+circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation
Authors: Elisabetta Ferrero, Daniela Belloni, Paola Contini, Chiara Foglieni, Maria Elena Ferrero, Monica Fabbri, Alessandro Poggi, Maria Raffaella Zocchi
Journal: Blood (2002)
An update on infantile haemangiomas
Authors: P.H. Hoeger
Journal: British Journal of Dermatology (2013)

Journal Article An update on infantile haemangiomas Get access P.H. Hoeger P.H. Hoeger Departments of Paerdiatrics and Paediatric Dermatology Wilhelmstift Children's Hospital 22149 Hamburg Liliencroustr Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 169, Issue 1, 1 July 2013, Page 11, https://doi.org/10.1111/bjd.12448 Published: 01 July 2013
Multiple Heavy-Chain Determinants on Individual B Lymphocytes in the Peripheral Blood of Patients with Sjögren's Syndrome
Authors: John A. van Boxel, John A. Hardin, Ira Green, William E. Paul
Journal: New England Journal of Medicine (1973)

Surface markers on peripheral blood lymphocytes were studied in Sjögren's syndrome. Cells bearing IgG, IgA, IgM and IgD were identified with monospecific fluorescent antiserums. In five of seven patients the frequency of cells identified with at least two anti-heavy-chain reagents was elevated. In two of these patients striking elevations were seen in the frequency of lymphocytes bearing each of the heavy-chain classes, the sum of the number of cells binding individual anti-heavy-chain serums being about four times greater than the apparent number of B lymphocytes as identified both with an anti-Fab reagent and by the binding of aggregated γ-globulin. The cells binding anti-heavy-chain serums were identified as B lymphocytes by doubling labeling procedures. These data indicate that individual B lymphocytes in some patients with Sjögren's syndrome bear multiple classes of heavy chains, an abnormality that has been noted by others in some patients with lymphoma. This association is of interest since there is a spectrum of benign to malignant lymphoproliferation in Sjögren's syndrome. (N Engl J Med 289:823–827, 1973)
Endoscopy Information Online: Can Endoscopists Close the Gap Between What is Known and What They Do?
Authors: J. Krabshuis
Journal: Endoscopy (1997)

When do you go to the Internet and when do you go to online hosts for information about gastrointestinal endoscopy? This paper describes key concepts such as hosts, online databases such as MEDLINE and EMBASE, search engines, retrieval and query languages, and thesauri. The focus is on two specific thesaurus issues: the use (or absence of) complex hierarchical thesauri such as MEDLINE's Medical Subject Headings (MeSH) and EMBASE's EMTREE. This allows us to review briefly the great advantages of "term explosion" and automatic mapping of synonyms (and the absence of these facilities on the Internet). The introductory section ends with questions on what your information needs are - clinical information? Product information? Patient information? Research information? The main part of the article is concerned with what is available on the Internet and the host services that are available today and in the future. A light glance (perhaps more of a provocative preview) is cast at future developments relevant to information retrieval in the field of endoscopy. Conclusions include the following: - The Internet should be searched for: guidelines, training, and product information. - There is little published research available for free on the Internet. - For published research, search MEDLINE and EMBASE together, or DIMDI, STN or DataStar (in that order of preference). - Search EMBASE if you need the most recent endoscopy research. - Search EMBASE if you need the most recent drug information relevant in endoscopy - Search MEDLINE if you have no budget. - Search PubMed as the preferred (free) form of access to MEDLINE. - Distrust all Internet information.
A CASE OF URTICARIA SOLARIS STUDIED WITH A MONOCHROMATOR.
Authors: I. A. MAGNUS, A. D. PORTER
Journal: British Journal of Dermatology (1959)

Journal Article A CASE OF URTICARIA SOLARIS STUDIED WITH A MONOCHROMATOR. Get access I. A. MAGNUS, M.R.C.P., I. A. MAGNUS, M.R.C.P. LecturerThe Institute of Dermatology, British Postgraduate Medical Federation and St. John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar A. D. PORTER, F.R.C.P. A. D. PORTER, F.R.C.P. PhysicianThe Institute of Dermatology, British Postgraduate Medical Federation and St. John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 71, Issue 2, 1 February 1959, Pages 51–60, https://doi.org/10.1111/j.1365-2133.1959.tb13385.x Published: 01 February 1959
A MODIFICATION OF LAGRANGE'S OPERATION
Authors: W. H. Kiep
Journal: BMJ (1929)

TzM BDgICR!ts4AL 3_11_13.So fai as tile specific proplhylaxi; of puerperal fever is Coll- cerned, it lias beeni shoown that whiile the exotoxinis of thle strepto- cocei causing puerper al sepsis can be neut ralized by any mono- vatiit sKreptococcal antitoxin, the dc:truetion of the organisms.i-bonly likely to be secured by the prlodtuctioni of a type (seloloorteal) specific anitibactelrial serinum. PREVENTION.W? thlesis is subm.oitted,therefore;, thlat in so far as the prev-enition of miiaternial mlortality is Concerned, andwi-itlli the limliits of our-present knowledgelt, a siuiiificant reduction ill mllaternal miior1tality wld be immediately attainie(l by wt) ami extension of adequate ante-natalI services, and (b) t1e inistitutioni of a niewi-niidwifc-doctor comiibination as a)ox-e (lefinied (pea(,,ragraph 11). DIAGNOSIS.WN'ithi referenice to the bacteriologicall diagno:-,is of plier-(r.alfev-er, confu-sion hias reslulted frani thwe wecalth of
Urgent Bilateral Nephrectomy for Severe Hypertension
Authors: J. M. LAZARUS
Journal: Annals of Internal Medicine (1972)

Eight hemodialysis patients with severe hypertension resistant to maximum reduction in extracellular volume underwent emergency bilateral nephrectomy to reverse complications of intractable heart failure, encephalopathy, and papilledema. Nephrectomy resulted in prompt reduction of blood pressure and resolution of complications, with low morbidity and no mortality. One patient with grade IV retinopathy had permanent optic nerve damage despite lower blood pressure after nephrectomy. Subsequently, resistant hypertension with decreasing vision was indication for immediate nephrectomy. Other indications for early bilateral nephrectomy and the treatment of these critically ill patients in the paraoperative period are discussed. Several months after nephrectomy three patients with "dry weight" again developed hypertension, but of a considerably more benign nature. The prompt improvement and smoother course of these patients lead us to suggest that bilateral nephrectomy should be considered earlier than previously recommended for dialysis patients with malignant hypertension.
Microarray Analysis of Ageing-related Signatures and Their Expression in Tumors Based on a Computational Biology Approach
Authors: Xiaosheng Wang
Journal: Genomics Proteomics & Bioinformatics (2012)

Ageing and cancer have been associated with genetic and genomic changes. The identification of common signatures between ageing and cancer can reveal shared molecular mechanisms underlying them. In this study, we collected ageing-related gene signatures from ten published studies involved in six different human tissues and an online resource. We found that most of these gene signatures were tissue-specific and a few were related to multiple tissues. We performed a genome-wide examination of the expression of these signatures in various human tumor types, and found that a large proportion of these signatures were universally differentially expressed among normal vs. tumor phenotypes. Functional analyses of the highly-overlapping genes between ageing and cancer using DAVID tools have identified important functional categories and pathways linking ageing with cancer. The convergent and divergent mechanisms between ageing and cancer are discussed. This study provides insights into the biology of ageing and cancer, suggesting the possibility of potential interventions aimed at postponing ageing and preventing cancer.
Hypoxic vasoconstriction increases with postnatal age in lungs from newborn rabbits.
Authors: C D Fike, T N Hansen
Journal: Circulation Research (1987)

Previous studies on the pressor response of the newborn pulmonary circulation to hypoxia have used intact animals and have reported conflicting results. Some have found an increase in responsiveness with increasing age; others have found a decrease. To circumvent many problems inherent in studies of pulmonary vascular reactivity in intact animals, we have developed methods for studying isolated, blood-perfused lungs from newborn rabbits. These methods have been used to study the influence of postnatal age on hypoxic pulmonary vasoconstriction. Two sets of experiments were performed. In the first, a stimulus response curve for hypoxic pulmonary vasoconstriction was constructed, using lungs from 19 rabbit pups that were 3-8 days old. At a constant blood flow, pulmonary artery pressure increased progressively as alveolar oxygen tension decreased so that the maximum increase from baseline (29.4 +/- 4.7%) occurred at PIO2 = 0. The pressor response to hypoxia was highly reproducible, and the entire system remained stable for over 2-3 hours. In the second set of experiments, we compared the pulmonary vascular response to hypoxia obtained using lungs from an additional 21 pups that were 3-8 days old with that obtained using lungs from 23 pups that were 10-14 days old. In response to the same hypoxic stimulus, pulmonary artery pressure increased more in lungs from older rabbit pups (56 +/- 4%) than in lungs from younger rabbit pups (34 +/- 7%) (p less than 0.001). We conclude that isolated perfused lungs from newborn rabbits exhibit a reproducible pressor response to alveolar hypoxia and that this response increases as a function of postnatal age.
Benign and Malignant Tumors of the Urinary Bladder
Authors: Rodney A. Mannion
Journal: JAMA (1972)

When I first looked into this volume, its inexpensive binding and type-setting did not make me optimistic regarding the contents. However, these doubts were dispelled by a full reading of the text. This is a comprehensive study of distinct pedagogic value. The foreword is perhaps the weakest aspect. The remaining six chapters get ever more informative as they cover the ground from pathology (Chap 2) through surgical treatment and chemotherapy (Chap 4 and 6, respectively). The final chapter, on etiology of bladder tumors, by J. M. Price, is a brilliant and perhaps definitive assembling of pertinent references. Bladder tumors, incidentally, are caused in many cases by environmental contamination, whether by dyes such as 2-napthylamine and benezidine or, in the case of animals, the bracken fern used as fodder. The "red water" disease of cattle is papillary carcinoma of the urinary bladder. There are many interesting references, including the first bladder
Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat.
Authors: M T Heneka, P A Löschmann, H Osswald
Journal: Journal of Clinical Investigation (1997)

Sepsis and its complications, hypotension, shock, and multiorgan failure continue to represent a significant cause of mortality among hospitalized patients, affecting approximately 200,000 patients per year in the US and 100,000 in Europe (Dal Nogare, A.R. 1991. Am. J. Med. Sci. 302:50-65.). Incidence rates appear to be increasing, probably due to an increase in the population with risk factors such as diabetes or invasive procedures. Activation of cytokines by endotoxins and subsequent formation of nitric oxide is of central pathogeneic importance in sepsis. In this study we show that polymerized bovine hemoglobin (Biopure 2) restores both cardiovascular and renal functions in an endotoxin-induced shock model in rats. These effects are compared to those of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine, and hydroxyethyl starch, the latter currently in clinical use for intravenous volume replacement. Our results clearly indicate that polymerized hemoglobin but not nitric oxide synthase inhibition or volume replacement normalize cardiovascular and kidney function in acute septic shock. This new therapeutic approach is readily applicable to controlled clinical trials because polymerized hemoglobin has been tested in humans and is therefore available for such studies.