Adult Respiratory Distress Syndrome Associated with Colchicine Intoxication
Authors: ROBERT N. HILL
Journal: Annals of Internal Medicine (1975)

Letters1 October 1975Adult Respiratory Distress Syndrome Associated with Colchicine IntoxicationROBERT N. HILL, M.D., ROGER G. SPRAGG, M.D., MARK K. WEDEL, M.D., KENNETH M. MOSER, M.D., F.A.C.P.ROBERT N. HILL, M.D.Search for more papers by this author, ROGER G. SPRAGG, M.D.Search for more papers by this author, MARK K. WEDEL, M.D.Search for more papers by this author, KENNETH M. MOSER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-4-523 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of respiratory distress in adults is characterized by the abrupt onset of dyspnea, diffuse pulmonary infiltration on chest roentgenogram, and marked hypoxemia. The precise cause is unknown, but the syndrome has been associated with trauma, shock, fat embolism, massive aspiration, acute viral pneumonia, pancreatitis, and drug ingestion (1). We report here a patient who developed the syndrome after ingestion of colchicine, a previously undescribed association.The patient was a previously healthy 18-year-old woman who, with suicidal intent, ingested approximately 150 mg of commercial grade colchicine powder, mixed with tea. Four hours later she noted mild epigastric pain and...References1. BLAISDELL F and SCHLOBOHM R: The respiratory distress syndrome: a review. Surgery 74:251-262, 1973 MedlineGoogle Scholar2. GAULTIER M: Present knowledge on acute colchicine poisoning. A report of 23 cases. Ann Med Interne (Paris) 120:605-611, 1969 MedlineGoogle Scholar3. HEALTH D, PALMER J, and AURBACH C: The hypocalcemic effect of colchicine. Endocrinology 90:1589-1596, 1972 CrossrefMedlineGoogle Scholar4. GOONERATNE B: Massive generalized alopecia after poisoning by Gloriosa superba. Br Med J 5494:1023-1024, 1966 CrossrefGoogle Scholar5. WALLACE S: Colchicine. Semin Arthritis Rheum 3:369-381, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT N. HILL, M.D.; ROGER G. SPRAGG, M.D.; MARK K. WEDEL, M.D.; KENNETH M. MOSER, M.D., F.A.C.P.Affiliations: Pulmonary Division University Hospital 225 W. Dickenson Street San Diego, California 92103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntitubulin Agents: Colchicine, Vinca Alkaloids, and PodophyllinAntitubulin Agents: Colchicine, Vinca Alkaloids, and PodophyllinA Teenager With Multiple Organ System DysfunctionColchicine poisoning: the dark side of an ancient drugColchicine – an Overview for Plant BiotechnologistsDrug-Induced Respiratory Disease in Connective Tissue DiseasesColchicine-induced bone marrow suppression: treatment with granulocyte colony-stimulating factorPULMONARY TOXICITY OF DRUGS USED TO TREAT SYSTEMIC AUTOIMMUNE DISEASESFatal colchicine overdose: Report of a case and review of the literatureColchicine poisoning-overview and new directionsPrinciples of management of the poisoned patientThe Cytoskeleton as a Target in Cell ToxicityTreatment of Severe Colchicine Overdose with Colchicine-Specific Fab FragmentsThe disruption of brain microtubules in vitro by the phospholipase inhibitor p-bromophenacyl bromideColchicine poisoningRESPIRATORY FAILURE AS A RESULT OF DRUGS, OVERDOSES, AND POISONINGSAntirheumatic drug reactions in the lungDrug-Induced Lung ToxicityColchicine intoxication: Clinical pharmacology, risk factors, features, and managementSystemic steroid therapy for acute gout: A clinical trial and review of the literaturePulmonary complications of antirheumatic drug therapyPulmonary Disease Due to Antirheumatic AgentsDrug-Induced Pulmonary ReactionsColchicine cardiotoxicity following ingestion of Gloriosa superba tubersDrug-induced pulmonary diseaseA Fatal Colchicine OverdoseThe Clinical Entity of Adult Respiratory Distress Syndrome: Definition, Prediction, and PrognosisSyndrome de détresse respiratoire aiguë de l'adulte au cours des intoxications par la colchicineMT and MT Poisons in Pathology and MedicineThe Adult Respiratory Distress SyndromeDrug-Induced Interstitial Lung DiseasesCAUSES OF THE ADULT RESPIRATORY DISTRESS SYNDROME—CLINICAL RECOGNITIONColchicine overdose: Report of two cases and review of the literatureAdult Respiratory Distress Syndrome Related to Ampicillin SensitivityThe Biosynthesis and Hormonal Regulation of Surfactant FormationSecretion, Exo- and EndocytosisAnti-inflammatory agents and drugs used in rheumatism and gout 1 October 1975Volume 83, Issue 4Page: 523-524KeywordsColchicineHypoxiaIngestionIntoxicationPancreatitisShockTeaThoraxVentilatorsViral pneumonia ePublished: 1 December 2008 Issue Published: 1 October 1975 PDF downloadLoading ...