tbuckley/cabot-search huggingface dataset:
Conscious thinking, acceptance, and self-deception
Authors: Keith Frankish
Journal: Behavioral and Brain Sciences (2011)

Abstract This commentary describes another variety of self-deception, highly relevant to von Hippel &amp; Trivers's (VH&amp;T's) project. Drawing on dual-process theories, I propose that conscious thinking is a voluntary activity motivated by metacognitive attitudes, and that our choice of reasoning strategies and premises may be biased by unconscious desires to self-deceive. Such biased reasoning could facilitate interpersonal deception, in line with VH&amp;T's view.
Prevalence and predictors of skin disease in the Women's Interagency HIV Study (WIHS)
Authors: Paradi Mirmirani, Nancy A. Hessol, Toby A. Maurer, Timothy G. Berger, Patricia Nguyen, Ann Khalsa, Alejandra Gurtman, Sandra Micci, Mary Young, Susan Holman, Stephen J. Gange, Ruth M. Greenblatt
Journal: Journal of the American Academy of Dermatology (2001)
Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells
Authors: H.‐Y. Tai, M. F. Tam, H. Chou, H.‐J. Peng, S.‐N. Su, D.‐W. Perng, H.‐D. Shen
Journal: Allergy (2005)

Background: Alkaline serine proteases from six prevalent airborne Penicillium and Aspergillus species have been identified as a group of major allergens (group 13). After entering human airways, the allergens are in initial contacts with respiratory epithelial cells. The purpose of this study is to investigate interactions between the Pen ch 13 allergen from P. chrysogenum and human lung epithelial cells. Methods: A549 cells, 16HBE14o‐ cells and primary cultures of human bronchial epithelial cells (HBEpC) were exposed to purified Pen ch 13 and mediators released into culture supernatants were assayed with enzyme‐linked immunosorbent assay (ELISA) kits. Cleavage of occludin in 16HBE14o‐ cells was analysed by immunofluorescent staining of whole cells and immunoblot analysis of whole cell extracts. Fragments generated by incubating Pen ch 13 and a synthetic peptide carrying the occludin sequence were analysed by mass spectrometry. Results: Pen ch 13 induced productions of prostaglandin‐E 2 (PGE 2 ), interleukin (IL)‐8 and transforming growth factor (TGF)‐ β 1 by A549 cells, 16HBE14o‐ cells and primary cultures of HBEpC. The protease activity of Pen ch 13 is needed for the induction of PGE 2 , IL‐8, TGF‐ β 1 and cyclo‐oxygenase (COX)‐2 expression. A tight junction protein occludin of 16HBE14o‐ cells can be cleaved by Pen ch 13 at Gln202 and Gln211 which are within the second extracellular domain of the protein. Conclusion: Pen ch 13 may contribute to asthma by damaging the barrier formed by the airway epithelium and stimulating the release of mediators that orchestrate local immune responses and inflammatory process from HBEpC.
Conference on ethical review of clinical research
Authors: J. Williams
Journal: BMJ (1992)

Ethics and multicentre research projects SIR,-We strongly support Peter Moodie's suggestion that there should be a "national committee to give conditional approval" to multicentre trials.' We have concerns about the role of local research ethics committees in these trials, which have been expressed by others.2Recent guidance from the Department of Health, which merely advised "that committees should arrive at a voluntary arrangement under which one [local' research ethics committee] is nominated to consider the issue on behalf of them all" simply dodges all the difficulties and will do nothing to help the organisers of large projects to get prompt, authori- tative advice on ethics.4Major research projects must have ethical review by independent professionals who are expert in many disciplines, including statistics, pharmacology, epidemiology, toxicology, and sociology, as well as having a practical understanding of ethical issues.Our district's local research ethics committee simply does not possess all this skill, though it does have knowledge of local circum- stances.We suspect that this may be true in other districts.In the past two years our committee has considered 114 research projects, of which no less than 70% have been multicentre drug trials.In considering these projects we have been repeating the work of many other such committees.Each local research ethics committee has its own application form, so researchers have to redraft their applications to suit the styles of different districts.This is an expensive waste of effort whose main effect is to deter research.Surely there should be, as Moodie suggests, an authoritative expert committee that could comment on multicentre research projects.These comments would be available to both local research ethics committees and researchers.This would both ensure high standards and smoothe the process of ethical approval.
Something New Out of Africa
Authors: T.E. Taylor, M.E. Molyneux
Journal: New England Journal of Medicine (1995)

It is rare, in these days of magnetic resonance imaging and gene sequencing, for investigators to make advances in our understanding of a common disease on the basis of bedside clinical observations alone, yet Kevin Marsh and his colleagues, working on the Kenyan coast, have succeeded in doing this for malaria in African children.1 Their contribution will have benefits both for preventive and for therapeutic programs.Malaria is flourishing. Despite efforts of clinicians, immunologists, entomologists, and pharmacologists, the death toll is rising. More than 3000 people die of malaria each day.2 The early efforts to eradicate malaria have evolved into . . .
Promoter swapping between the genes for a novel zinc finger protein and β-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations
Authors: Koen Kas, Marianne L. Voz, Eva Röijer, Anna-Karin Åström, Eva Meyen, Göran Stenman, Wim J.M. Van de Ven
Journal: Nature Genetics (1997)
RABIES VACCINE IN THE TREATMENT OF EPILEPSY
Authors: Isidore Finkelman, Alex J. Arieff, Maurice A. Schiller
Journal: American Journal of Psychiatry (1938)

In view of the reports of the cessation of seizures in patients with epilepsy following a course of treatment with antirabic vaccine, we administered this form of therapy to 13 patients with epilepsy. There was no critical change in the frequency or severity of the seizures as a result of rabies vaccine therapy.
Prematurity and Mortality in Childhood and Early Adulthood—Reply
Authors: Casey Crump, Kristina Sundquist, Jan Sundquist
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Unusual Case of Active Tuberculosis of the Oesophagus in an Adult
Authors: N. Tornieporth, R. Lorenz, T. Gain, T. Rösch, M. Classen
Journal: Endoscopy (1991)

See also: Esophageal Tuberculosis: Early Diagnosis by EndoscopyEndoscopy 1993; 25(07): 485-485DOI: 10.1055/s-2007-1010374
Use of the light-emitting diode-illuminated endoscope for upper gastrointestinal endoscopy
Authors: S. Kiyotoki, J. Nishikawa, H. Yanai, T. Okamoto, S. Higaki, T. Taguchi, I. Sakaida
Journal: Endoscopy (2009)

We have developed the white light-emitting diode (LED)-illuminated endoscopes and previously reported our preliminary experiments with the prototype LED endoscope in the beagle [1]. Authors in Nature noted that the white LEDs we employed have been used for illuminating paintings in fine art museums, as they emit white light with good color rendering and homogeneous light distribution [2] [3]. This supports the notion that these LEDs may also be suitable for use in gastrointestinal endoscopes, as these instruments must be able to indicate subtle changes in the color and mucosal structure of the gastrointestinal tract.
Dr Adrian M.Johnson, CBE, FRACP, FRACR, FACD
Authors: H.F. Molloy
Journal: British Journal of Dermatology (1989)

Journal Article Dr Adrian M.Johnson, CBE, FRACP, FRACR, FACD Get access H.F. Molloy H.F. Molloy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 1, 1 July 1989, Pages 139–141, https://doi.org/10.1111/j.1365-2133.1989.tb01411.x Published: 01 July 1989
One in three German hospitals faces bankruptcy
Authors: Annette Tuffs
Journal: BMJ (2006)

Every third hospital in Germany is facing bankruptcy, says a report from the consulting firm McKinsey. The main reason is the introduction of a new financing system by 2009, under which fixed uniform charges will be paid for a standard treatment per case. This will reduce the overall German hospital budget by 荤5bn (£3.4bn; $6.4bn). But it will mean that large hospitals receive the same money for an appendicitis case as small hospitals, which have potentially greater overhead costs. …
Preparation and Evaination of Tc-99m Labeted Vapreotide (RC-160); A somatostatin analog
Authors: Kolan HR, Thakur ML, Wiaderkeiwcz R., Li J, Duggaraju R
Journal: Clinical Nuclear Medicine (1996)

Dept. of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107 This work was supported by ACS 377.
Atypical psoriasis of the face and hands after PUVA treatment
Authors: A.R. VERHAGEN, A.G WIEL, G.G. WUITE
Journal: British Journal of Dermatology (1984)

In sixty patients with psoriasis, two types of lesions developed after repeated and prolonged courses of PUVA radiation. In sixteen patients, new lesions on the face resembled seborrhoeic dermatitis; in thirteen patients thick plaques on the dorsum of the hands developed insidiously over the years. There was no significant association between the two types of lesions and only the latter were dose-related. The appearance of recalcitrant psoriasis on the face and hands appears to be a complication of PUVA treatment.
Pathogenesis of amoebiasis.
Authors: R A Neal
Journal: Gut (1971)

Progress report Pathogenesis of amoebiasisIn recent years the species complex of amoebae infesting man which produce four-nucleate cysts has been divided into three groups.First the amoebae, described previously as the small race E. histolytica, are separated into a distinct species E. hartmannil based on size and absence of virulence.Second, amoebae which are indistinguishable morphologically from true E. histolytica but are able to grow and multiply at temperatures below 37°C are known as E. histolytica-like amoebae.The optimum temperature for their growth is about 26°C.These isolates have, until recently, only been discovered in North America2.Attempts to find such strains in Great Britain have so far failed3, although a report of the isolation of low-temperature E. histolyticalike amoebae from Sicily has appeared4.The third group consists of true E. histolytica.Amoebae of this group were previously described as the large race and only these amoebae are responsible for invading tissue in man.This progress report concerns the pathogenicity of true E. histolytica.
VESSEL RESPONSE TO THE NOVEL POLYMER-FREE BIOFREEDOM STENT VERSUS CONVENTIONAL DURABLE POLYMER COATING STENT: SHORT- AND MID-TERM INTRAVASCULAR ULTRASOUND RESULTS FROM THE BIOFREEDOM FIRST-IN-MAN TRIAL
Authors: Kenji Sakata, Byeong-Keuk Kim, Hiromasa Otake, Katsuhisa Waseda, Gerhard C. Schuler, Karl E. Hauptmann, Joachim Schofer, Paul G. Yock, Yasuhiro Honda, Eberhard Grube, Peter J. Fitzgerald
Journal: Journal of the American College of Cardiology (2011)
Instructional Videos on Food Safety in Nursing Homes
Authors: Stuart L. Nightingale
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diving is dangerous for diabetics
Authors: P. Watkins, G S Spathis
Journal: BMJ (1981)

a period of 15 months, 578 patients were discharged from the wards of one geriatric unit at Queen's Hospital, Croydon, and of these only 16 (2 8%/') were readmitted within eight weeks of discharge.We examined carefully the arrangements made for the discharge and follow-up of these 16, in an attempt to identify possible preventable causes of rapid read- mission.They had previously been in hospital for a mean of 24-3 days (range 9-66 days).Eight readmissions were found to be unavoid- able owing to the development of new illness or an unpredictable exacerbation of previous illness.Only five patients came back within a week, and only three of these within 48 hours, which Dr Nasar and Professor Millard consider to be the crucial period.Of these three, two lived alone and relied on neighbours in addition to social services support.Both district nursing services and social services provided support as previously organised, and no patient was readmitted owing to failure of services.Our experience suggests that although it is important to reduce the length of stay of elderly people in hospital (6 June, p 1817), it is equally important to plan discharge very care- fully with the support of good social services, district nurses, and general practitioners; and if this is done there appears to be no need for a hospital-based visiting service or flying squad to cover the period immediately after discharge.In 13 of our patients readmission was asso- ciated with falls, confusion, or incontinence (or a combination of these).It might be more appropriate to consider a domiciliary visit to patients who develop these problems, than to expend time and manpower on routine visits to all patients after discharge.
RTEF-1 Attenuates Blood Glucose Levels by Regulating Insulin-Like Growth Factor Binding Protein-1 in the Endothelium
Authors: Angela F. Messmer-Blust, Melissa J. Philbrick, Shuzhen Guo, Jiaping Wu, Ping He, Shaodong Guo, Jian Li
Journal: Circulation Research (2012)

Related transcriptional enhancer factor-1 (RTEF-1) plays an important role in endothelial cell function by regulating angiogenesis; however, the mechanism underlying the role of RTEF-1 in the endothelium in vivo is not well defined.We investigated the biological functions of RTEF-1 by disrupting the gene that encodes it in mice endothelium -specific RTEF-1-deficient transgenic mice (RTEF-1(-/-)).RTEF-1(-/-) mice showed significantly increased blood glucose levels and insulin resistance, accompanied by decreased levels of insulin-like growth factor binding protein-1 (IGFBP-1) mRNA in the endothelium and decreased serum IGFBP-1 levels. Additionally, the RTEF-1(-/-) phenotype was exacerbated when the mice were fed a high-fat diet, which correlated with decreased IGFBP-1 levels. In contrast, vascular endothelial cadherin/RTEF-1-overexpressing(1) transgenic mice (VE-Cad/RTEF1) demonstrated improved glucose clearance and insulin sensitivity in response to a high-fat diet. Furthermore, we demonstrated that RTEF-1 upregulates IGFBP-1 through selective binding and promotion of transcription from the insulin response element site. Insulin prevented RTEF-1 expression and significantly inhibited IGFBP-1 transcription in endothelial cells in a dose-dependent fashion.To the best of our knowledge, this is the first report demonstrating that RTEF-1 stimulates promoter activity through an insulin response element and also mediates the effects of insulin on gene expression. These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. These findings provide the basis for novel insights into the transcriptional regulation of IGFBP-1 and contribute to our understanding of the role of vascular endothelial cells in metabolism.
ADVANTAGES OF BROMINIZED OIL IN BRONCHOGRAPHY IN TUBERCULOUS PATIENTS
Authors: SAMUEL IGLAUER
Journal: JAMA (1928)

The practical value of introducing opaque substances into the tracheobronchial tree as an aid to the roentgen-ray diagnosis of obscure pulmonary lesions has become firmly established. Following the pioneer publications of Sicard and Forestier<sup>1</sup>and Sargent and Cottenot,<sup>2</sup>bronchography was soon enthusiastically taken up by French, German, Danish, Russian and American observers. The opaque medium commonly employed consists of a vegetable oil firmly combined with about 40 per cent by weight of iodine. As a general rule, iodized oil is well tolerated by the pulmonary tissues, and only occasionally have deleterious results been reported. In the diagnosis of bronchiectasis, the most brilliant results have been obtained. The size, shape and distribution of the cavities are readily delineated, and bronchiectasis, especially in children, has been found to be more frequent than is commonly supposed. Bronchial fistulas and empyema cavities are thoroughly delineated by injection, and in several of our
Investigative Bronchoprovocation and Bronchoscopy in Airway Diseases
Authors: William W. Busse, Adam Wanner, Kenneth Adams, Herbert Y. Reynolds, Mario Castro, Badrul Chowdhury, Monica Kraft, Robert J. Levine, Stephen P. Peters, Eugene J. Sullivan
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Basic and clinical research strategies used for many lung diseases have depended on volunteer subjects undergoing bronchoscopy to establish access to the airways to collect biological specimens and tissue, perhaps with added bronchoprovocation in asthma syndromes. These procedures have yielded a wealth of important scientific information. Since the last critical review more than a decade ago, some of the techniques and applications have changed, and untoward events have occurred, raising safety concerns and increasing institutional review scrutiny.To reappraise these investigational methods in the context of current knowledge, the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health convened a working group to review these procedures used for airway disease research, emphasizing asthma and chronic obstructive pulmonary disease.The group reaffirmed the scientific importance of investigative bronchoscopy and bronchoprovocation, even as less invasive technologies evolve. The group also considered the safety of bronchoscopy and bronchoprovocation with methacholine and antigen to be acceptable for volunteer subjects and patients, but stressed the need to monitor this closely and to emphasize proper training of participating medical research personnel. Issues were raised about vulnerable volunteers, especially children who need surrogates for informed consent.This review of investigative bronchoscopy and bronchoprovocation could serve as the basis for future guidelines for the use of these procedures in the United States.
Intravascular Large B-Cell Lymphoma With Acute Abdomen As a Presenting Symptom in a Patient With Systemic Lupus Erythematosus
Authors: Wataru Ishii, Satoshi Ito, Yuya Kondo, Hiroto Tsuboi, Mizuko Mamura, Daisuke Goto, Isao Matsumoto, Akito Tsutsumi, Takayuki Sumida, Yasushi Okoshi, Yuichi Hasegawa, Hiroshi Kojima, Shingo Sakashita, Kumi Aita, Masayuki Noguchi
Journal: Journal of Clinical Oncology (2008)
Imaging Stem Cell-derived Persistent Foci After In Vivo Selection of Lentiviral MGMT-P140K Transduced Murine Bone Marrow Cells
Authors: Yuan Lin, Perrin Cheung, Justin C Roth, David L Wilson, Stanton L Gerson
Journal: Molecular Therapy (2011)

The engraftment of hematopoietic stem cells (HSCs) after drug resistance gene transfer and drug selection may recapitulate stress response hematopoiesis, but the processes remain elusive. Homing, trafficking, and localization of transduced cells and the impact of insertion site on focal expansion have not been well characterized. With the goal of optimizing and understanding these processes under conditions of low multiplicity of infection (MOI) lentiviral gene transfer, we used drug resistance gene O(6)-methylguanine-DNA methyltransferase (MGMT)-P140K and in vivo selection to enrich for transduced and transgene-expressing HSCs. To systemically monitor homing, trafficking, and expansion after transplantation and drug selection over time, we linked MGMT-P140K to the firefly luciferase gene in lentiviral self-inactivating vectors. Periodic bioluminescence imaging (BLI) of transplanted recipients was followed for up to 9 months after both primary and secondary transplantation. Initial dispersion and widespread early homing and engraftment were transient, followed by detection of persistent and discrete foci at stable tissue sites after in vivo drug selection. From these studies, we concluded that drug resistance gene transfer followed by early or late drug selection can result in stable gene expression and cell expansion in persistent foci of transduced bone marrow cells that often remain in fixed sites for extended periods of time.