Long-Term Prevention of Bone Loss
Authors: Pernille Ravn, Richard D. Wasnich, Giovanni Cizza
Journal: Annals of Internal Medicine (2000)

Letters4 July 2000Long-Term Prevention of Bone LossPernille Ravn, MD, Richard D. Wasnich, MD, and Giovanni Cizza, MD, PhDPernille Ravn, MDCenter for Clinical and Basic Research; Ballerup, Denmark (Ravn)Hawaii Osteoporosis Center; Honolulu, HI 96814 (Wasnich)National Institute of Mental Health; Bethesda, MD 20892 (Cizza)Search for more papers by this author, Richard D. Wasnich, MDCenter for Clinical and Basic Research; Ballerup, Denmark (Ravn)Hawaii Osteoporosis Center; Honolulu, HI 96814 (Wasnich)National Institute of Mental Health; Bethesda, MD 20892 (Cizza)Search for more papers by this author, and Giovanni Cizza, MD, PhDCenter for Clinical and Basic Research; Ballerup, Denmark (Ravn)Hawaii Osteoporosis Center; Honolulu, HI 96814 (Wasnich)National Institute of Mental Health; Bethesda, MD 20892 (Cizza)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Lesser hypothesizes that calcium or vitamin D deficiency might have biased our main study finding that alendronate prevents bone loss over 4 years (1). We elected to assess dietary calcium intake and offer nutritional advice rather than provide calcium and vitamin D supplementation. We believed that this naturalistic approach was more appropriate because the prevalence of calcium and vitamin D deficiency is likely to be low in healthy postmenopausal women. We also considered the issue of whether calcium supplementation can prevent bone loss in younger postmenopausal women to be controversial (2). The controversy did, however, prompt us ...References1. Ravn P, Bidstrup M, Wasnich RD, Davis JW, McClung MR, Balske A, et al . Alendronate and estrogen–progestin in the long-term prevention of bone loss: four-year results from the Early Postmenopausal Intervention Cohort Study. A randomized, controlled trial. Ann Intern Med. 1999;131:935-42. LinkGoogle Scholar2. Dawson-Hughes B. Calcium supplementation and bone loss: a review of controlled clinical trials. Am J Clin Nutr. 1991;54 Suppl 1 274S-280S. CrossrefMedlineGoogle Scholar3. Hosking DJ, Ross PD, Thompson DE, Wasnich RD, McClung M, Bjarnason NH, et al . Evidence that increased calcium intake does not prevent early postmenopausal bone loss. Clin Ther. 1998;20:933-44. CrossrefMedlineGoogle Scholar4. Hosking D, Chilvers CE, Christiansen C, Ravn P, Wasnich R, Ross P, et al . Prevention of bone loss with alendronate in postmenopausal women under 60 years of age. Early Postmenopausal Intervention Cohort Study Group. N Engl J Med. 1998;338:485-92. CrossrefMedlineGoogle Scholar5. Wasnich RD, Miller P. Antifracture efficacy of antiresorptive agents are related to changes in bone density. J Clin Endocrinol Metab. 2000;85:231-6. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Pernille Ravn, MD; Richard D. Wasnich, MD; Giovanni Cizza, MD, PhDAffiliations: Center for Clinical and Basic Research; Ballerup, Denmark (Ravn)Hawaii Osteoporosis Center; Honolulu, HI 96814 (Wasnich)National Institute of Mental Health; Bethesda, MD 20892 (Cizza) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAlendronate and Estrogen–Progestin in the Long-Term Prevention of Bone Loss: Four-Year Results from the Early Postmenopausal Intervention Cohort Study: A Randomized, Controlled Trial Pernille Ravn , Marianne Bidstrup , Richard D. Wasnich , James W. Davis , Michael R. McClung , Ana Balske , Carol Coupland , Opinder Sahota , Amarjot Kaur , Marianne Daley , and Giovanni Cizza , for the Early Postmenopausal Intervention Cohort Study Group*Long-Term Prevention of Bone Loss Gerson T. Lesser Metrics 4 July 2000Volume 133, Issue 1Page: 72-73KeywordsAdverse eventsBoneBone mineral densityBone resorptionCalciumNutritionOsteoporosisVitamin DVitamin D deficiency ePublished: 15 August 2000 Issue Published: 4 July 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...