tbuckley/cabot-search huggingface dataset:
Color-Vision Defects in American School Children
Authors: Horace C. Thuline
Journal: JAMA (1964)

A study of color-vision using Ishihara plates and the pseudoisochromatic plates designed by Hardy, Rand, and Rittler (HRR) was made of 10,341 students in all grades in an American school district. The tests were compared and the Ishihara plates were found more accurate for detecting defects, and the HRR more apt to give problems in interpreting results for borderline situations. The HRR was found more useful in classifying the type of red-green color-vision defect present in severely affected cases and for detection of defects in perception involving blues and yellows. Among the 5,263 boys, 6.2% had a defect, and 0.55% of the 5,078 girls had a defect. An unexpected ancillary finding was the lack of student, parental, and teacher recognition of the presence of color-perception problems in a majority of those identified.
Cardiac Hypertrophy in Hypertension
Authors: Edward D. Frohlich
Journal: New England Journal of Medicine (1987)

Over the past three decades, increasing attention has focused on the hypertensive diseases. During this period, antihypertensive therapy was introduced, and its safety and efficacy were demonstrated. Accompanying these advances in therapy was a tremendous expansion in our understanding of the underlying pathophysiologic mechanisms of hypertensive diseases. With respect to the role of the cardiovascular system in hypertension, investigators in the 1960s and '70s called attention to the heterogeneity of the systemic and regional hemodynamic alterations associated with the hypertensive diseases.1 By the late 1970s and '80s, more interest was being directed to the role of the heart in hypertension. . . .
TCT-11 Angiographic Appearance of Spontaneous Coronary Artery Dissection with Intramural Hematoma Proven on Intracoronary Imaging
Authors: Jacqueline Saw, G. B. John Mancini, Karin Humphries, Anthony Fung, Andrew Starovoytov, Eve Aymong
Journal: Journal of the American College of Cardiology (2014)
"Epidemic" Abdominal Colic Associated with Steatorrhoea
Authors: M. E. M. Thomas
Journal: BMJ (1952)

PREPARATIONBxrnm 691 side-effects was not vitamin B1 but an impurity present in A, absent in B, and present in traces in C.This substance was therefore probably a carry-over impurity from the streptomyces fermentation liquor (Tables I andI1I).( 2 )People who had previously received penicillin or other antibiotics were more than twice as likely to be skin-sensitive and to develop side-effects to the "mould impurities " as those'who had not been so treated (Tables II andIV).
Three Cases of Agranulocytosis
Authors: P. R. Graves
Journal: BMJ (1947)

Kahn and Wassermann reactions negative.X-ray examination disclosed great delay, chiefly in the ascending and transverse colons, and a barium enema ran easily back to the caecum, causing huge dilatation of the whole large bowel.The blood, urine, and faeces showed no abnormality.In view of his mental state, and realizing the futility of further medical treatment, I decided to operate.Laparotomy was performed on Jan. 20, 1940.There were no adhesions or bands, and the only pathological feature was a slightly dilated extremely mobile colon.The dilatation was most pronounced in the ascending and transverse colons, and beyond the
INTRAVENOUS THERAPY AND VENOCLYSIS
Authors: G. A. Hendon
Journal: JAMA (1934)

<h3>To the Editor:—</h3> Reading the communication on the intravenous drip by W. Forrest Dutton inThe Journal, October 20, was like hearing from an old friend, because his book Intravenous Therapy has been my vade mecum since its publication. I was surprised to learn that any discussion had arisen over the priority of the intravenous drip. I had always ascribed that honor to Dr. Matas and never supposed that there was any question or doubt about it. In my paper of December 1924 in<i>Southern Surgical Transactions</i>for 1924 will be found quotations with ample credit to Friedman, Penfield and Teplitz, Unger and Huess, Matas, Woodyatt, Sansum and Wilder. My "bid for fame" rests on the fact that I have devised an apparatus and worked out a technic by which this "means of grace" is made instantly available and its range of useful application expanded almost without limit in the
Abstract 4264: PI3K/Akt/mTOR signaling modulation in solar UV-induced skin carcinogenesis.
Authors: Yira Bermudez, Steve P. Stratton, Clara Curiel-Lewandrowski, Chengcheng Hu, George T. Bowden, Kathylynn Saboda, David S. Alberts, Janine G. Einspahr
Journal: Cancer Research (2013)

Abstract Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common types of cancers. Since most BCC and SCC develop on sun-exposed areas of the body, chronic sun exposure is considered the main etiologic factor of these tumors. In vitro and in vivo studies have identified PI3K/Akt/mTOR signaling pathway as a solar light-activated pathway. However, little work has been done on studying the expression profiles of this pathway in humans. In the study herein, we evaluate the modulation of solar light-activated PI3K/Akt/mTOR signaling pathway in normal human skin and solar simulated light (SSL)-irradiated human skin to determine the expression profiles of upstream and downstream phosphorylated proteins Akt (Ser473), mTOR (Ser2448), S6 ribosomal protein (Ser235/236), and 4E-BP1 (Thr37/46). The study population consisted of individuals 18 years or older in general good health with skin types II-III. SSL irradiation at 2, 2.5, and 3 times minimal erythema dose (MED) were applied to unexposed skin. Punch biopsies were taken at baseline, 5 minutes, 1 h, 5 h, and 24 h post-irradiation and immediately fixed in 10% formalin. Tissues were evaluated by immunohistochemistry for the expression of phosphorylated proteins. Proliferating cell nuclear antigen (PCNA) and cleaved caspase 3 (Asp175) were evaluated as markers for keratinocyte proliferation and apoptosis, respectively. Induction of phosphorylated Akt was seen at 5 hours with a 2-fold increase in expression when compared to baseline. Expression of phosphorylated mTOR gradually increased with a peak at 24 hours (3-fold). Significant induction of phosphorylated S6 ribosomal protein was seen at 1 h (3-fold), 5 h (7-fold), and 24 h (10-fold) post SSL irradiation. Induction of phosphorylated 4E-BP1 was limited to the 24 h time point with an increase of 2-fold when compared to baseline. Our data corroborate in vitro and in vivo studies finding, which allow for better understanding of the expression profile patterns of phosphorylated proteins in the PI-3 kinase/Akt/mTOR pathway during exposure of physiological relevant solar-simulated light. Identification of key proteins in this pathway could lead to the use of these proteins as biomarkers and/or specific targets for the prevention and control of skin tumors. Citation Format: Yira Bermudez, Steve P. Stratton, Clara Curiel-Lewandrowski, Chengcheng Hu, George T. Bowden, Kathylynn Saboda, David S. Alberts, Janine G. Einspahr. PI3K/Akt/mTOR signaling modulation in solar UV-induced skin carcinogenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4264. doi:10.1158/1538-7445.AM2013-4264
Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation
Authors: N M Wulffraat
Journal: Annals of the Rheumatic Diseases (2003)

To determine whether myeloid related proteins (MRP8/MRP14), a complex of two S100 proteins related to neutrophil and monocyte activation, might be used as a marker for disease activity, and as an early indicator of relapse in juvenile idiopathic arthritis.A group of 12 patients who underwent an autologous haematopoietic stem cell transplantation (ASCT) for refractory juvenile idiopathic arthritis (JIA) were studied. MRP8/MRP14 serum concentrations were determined by a sandwich enzyme linked immunosorbent assay (ELISA) as described. Improvement from baseline was described by a definition of improvement employing a core set of criteria as detailed previously by Giannini.After ASCT, MRP8/MRP14 serum concentrations in JIA showed a positive correlation with the Child Health Assessment Questionnaire (CHAQ; r=0.80) and erythrocyte sedimentation rate (r=0.45), but not with the total leucocyte count (r=0.26). Mean MRP8/MRP14 serum concentrations dropped markedly in the first three months after ASCT (p=0.0039) and clinical parameters of disease activity such as CHAQ markedly improved (p=0.0039). During a transient relapse there was an increase in MRP8/MRP14.MRP8/MRP14 serum concentration can be used as a marker for disease activity in patients who receive an ASCT for refractory JIA. This indicates a role of macrophage activation in the pathogenesis of JIA. The occurrence of MAS in three patients in this study was not preceded by significant changes in MRP8/MRP14 concentration.
Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression
Authors: Wei-Jia Kong, Hao Zhang, Dan-Qing Song, Rong Xue, Wei Zhao, Jing Wei, Yue-Ming Wang, Ning Shan, Zhen-Xian Zhou, Peng Yang, Xue-Fu You, Zhuo-Rong Li, Shu-Yi Si, Li-Xun Zhao, Huai-Ning Pan, Jian-Dong Jiang
Journal: Metabolism (2008)
Meditation Intervention Reviews
Authors: Thomas Rutledge, Paul Mills, Robert Schneider
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Treatment of Typhoid Fever.
Authors: H. W. Yemans
Journal: JAMA (1896)

June8, 1896. <h3>To the Editor:</h3> —I have been much interested in the discussion of the "Woodbridge" treatment of enteric fever, and I am greatly pleased to see that many realize the necessity for fulfilling what I have long considered the essential requirements in not only this, but most, if not all, intestinal disturbances, viz.: Rid the digestive canal, promptly and thoroughly, of all offending or decomposing matter, together with the products of decomposition, thus preventing their absorption; render the contents of the entire tract aseptic as far as possible, and lastly—this and the first being, to my mind, the prime consideration—inducing decided alkalinity, as it is in acid media that most, nearly all, the obnoxious microörganisms thrive best. The degree of alkalinity should be positive and sufficient, and as, within reasonable limits, there is no danger of overdoing the matter, large quantities of alkali, preferably bicarbonate of sodium, should
Diagnosis and Treatment of Streptococcal Pharyngitis
Authors: H. William Fink
Journal: JAMA (1985)

To the Editor.—  Dr Vincent Fulginiti, 1 in his excellent editorial, implies that the retching febrile child who clutches his throat in pain probably has streptococcal pharyngitis. I believe this is somewhat misleading. It has been my experience that children with viral pharyngitis, infectious mononucleosis, and postnasal drip are more apt to have presenting complaints of severe sore throat. It is not unusual for the child with streptococcal pharyngitis or scarlet fever to present with some malaise and fever, and to mention a sore throat only on being questioned about it.  For the past six months, we have been using the throat swab rapid-diagnosis method for confirming the diagnosis of streptococcal pharyngitis. We initially ran the tests along with our previous bacitracin-disk agar plate cultures and found virtual
The use of out of hours health services: a cross sectional survey
Authors: C. Brogan, D. Pickard, A. Gray, S. Fairman, A. Hill
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objectives:</b> To determine the use and costs of the principal out of hours health services in Buckinghamshire. <b>Design:</b> Prospective cross sectional survey and cost description of patient contacts with out of hours services. <b>Setting:</b> Buckinghamshire during March and April 1995. <b>Subjects:</b> General practices, accident and emergency departments, ambulance services, and community nursing services. <b>Main outcome measure:</b> Contacts with patients and cost of out of hours services. <b>Results:</b> 438 patient contacts/1000 population/year were recorded at an annual incremental cost of between £4.6m and £7.2m (depending on the costing of general practitioner services), for a population of 660 000. Of these contacts, 21 649 (45%) were with general practitioners. Night time contacts with all services diminished sharply after 10 pm. General practitioners considered that 40% of contacts were unnecessary or could have waited until morning. Over 70% of contacts were for upper respiratory tract infections, earache, gastroenteritis, and other minor ailments. Nursing care was predominantly for elderly people, and 33% of nursing contacts were to supervise medication. Accident and emergency care was predominately for young adults, especially men, and 41% of attendances were for medical conditions. <b>Conclusions:</b> New models such as multidisciplinary primary care centres with telephone advice lines and triaging are required to ensure high quality, cost effective care that is responsive to the needs of both consumers and professionals. <h3>Key messages</h3> We studied the out of hours activity of six general practices and the local accident and emergency department in Nottingham for six months There were wide variations between electoral wards in both general practice and accident and emergency events Deprivation scores explained more than half of the variation, with out of hours activity being highest in deprived inner city areas Highly deprived areas close to the accident and emergency department generated high levels of work for both general practice and accident and emergency services, with no evidence of one service substituting for the other
Imipramine in Alopecia Areata
Authors: Giulia Perini, Michele Zara, Roberto Cipriani, Christian Carraro, Antonio Preti, Franco Gava, Paola Coghi, Andrea Peserico
Journal: Psychotherapy and Psychosomatics (1994)

Alopecia areata (AA) is a dermatologic disease whose onset is significantly associated to life events. Its course may often be characterized by high levels of anxiety and depression. These observations suggested a rationale for using an antidepressant in AA. Thirteen patients were enrolled in a double-blind, placebo-controlled study of efficacy of imipramine in alopecia. After six months clinically significant hair regrowth occurred in 5 of the 7 patients on imipramine, whereas no response was observed in the placebo group. An improvement in psychic symptomatology was present in both groups. Our preliminary results indicate the potential efficacy of imipramine in patients with AA, not acting directly through a reduction of anxiety or depression.
Gastrointestinal Intramural Hematoma, a Complication of Endoscopic Injection Methods for Bleeding Peptic Ulcers: A Case Series
Authors: B. Rohrer, J. Schreiner, P. Lehnert, H. Waldner, W. Heldwein
Journal: Endoscopy (1994)

In a prospective study, all patients with peptic ulcer bleeding were documented between February 1984 and April 1992. A total of 227 patients were treated by local injection of epinephrine followed by laser application and injection of polidocanol or fibrin tissue adhesive. In five of these patients, intramural hematomas developing at the former bleeding site one to three days after endoscopic treatment were observed. The presenting symptoms were abdominal pain, nausea, and vomiting. The diagnosis was established by endoscopy, abdominal ultrasound, computed tomography, or laparotomy. In four of our five patients, the bleeding site and hematoma were located in the duodenum. All patients suffered from severe underlying diseases, and showed a clear disturbance of coagulation parameters. In three patients, acute pancreatitis occurred concurrently with the hematoma, probably due to obstruction of the papilla of Vater or compression of the pancreas caused by the hematoma.
Pneumosilicosis and Amyloidosis*†
Authors: J. B. CAREY
Journal: Annals of Internal Medicine (1933)

Article1 February 1933Pneumosilicosis and AmyloidosisReport of a Case of Asymptomatic Pulmonary Silicosis and Amyloid Kidney; Death from Uremia.J. B. CAREY, M.D., F.A.C.P.J. B. CAREY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-8-1106 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe condition of pneumosilicosis is in itself of interest only as an occupational disease. Its gradual production by intermittent rather than by constant exposure to silica-bearing dust, without apparent symptoms and with no accompanying infection, may perhaps be unusual. The deposition of silica-bearing particles of foreign material in the lung, causes much fibrosis. That this fibrosis is the direct result of irritation by the silica itself, and not of simple mechanical traumatization of pulmonary tissue by a foreign agent as such, is conceded. In individuals in whose lungs silica has been deposited, symptoms apparently result from the secondary infections which...References1 YOKOI Y: Amyloid formation due to injection of blood and sodium silicate solution in mice, Trans. Jap. Path. Soc., 1928, xviii, 237. Google Scholar2 SATO S: Influence of extirpation of one kidney upon amyloid formation due to intravenous injection of sodium silicate solution in rabbit, Trans. Jap. Path. Soc., 1928, xviii, 240. Google Scholar3 MURATAYOSHIKAWA MS: Experimentelle Erzeugung von Amyloidose durch orale und parenterale Verabreichung der Kieselsäure und einer ihrer Verbindungen, Virchow's Arch. f. path. Anat., 1927, cclxiv, 587-604. CrossrefGoogle Scholar4 VON SCHNIZER : Angeblicher Zusammenhang zwischen Amyloidniere und Dienstbeschädigung abgewiesen, Med. Klin., 1926, xxii, 776-777. Google Scholar5 NOBLEMAJOR JFSG: Renal insufficiency in amyloid disease, Arch. Path., 1929, viii, 762-774. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Read before the Minnesota Society of Internal Medicine, June 4, 1932.†From the Department of Medicine, The Nicollet Clinic, Minneapolis, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByÜber den Einfluß der nicht „erheblichen” Silikose auf den Verlauf einer aktiven LungentuberkuloseRENAL AMYLOIDOSIS WITH CLINICAL FINDINGS SUGGESTIVE OF POLYCYSTIC KIDNEY*FRANK L. JENNINGS, M.D., F.A.C.P., HUGO O. ALTNOW, M.D., F.A.C.P., GEORGE K. HIGGINS, M.D.THE CLINICAL MANIFESTATIONS OF AMYLOIDOSIS*MILTON B. ROSENBLATT, M.D. 1 February 1933Volume 6, Issue 8Page: 1106-1114KeywordsDustLungsPulmonary fibrosis Issue Published: 1 February 1933 PDF DownloadLoading ...
Ultrastructural Alterations in Intraalveolar Surfactant Subtypes after Experimental Ischemia and Reperfusion
Authors: MATTHIAS OCHS, ILIJA NENADIC, ANTONIA FEHRENBACH, JOHANNES M. ALBES, THORSTEN WAHLERS, JOACHIM RICHTER, HEINZ FEHRENBACH
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Ischemia and reperfusion (I/R) result in surfactant dysfunction. Whether the impairment of surfactant is a consequence or a cause of intraalveolar edema formation is still unknown. The cumulative effects of lung perfusion, ischemic storage, and subsequent reperfusion on surfactant ultrastructure and pulmonary function were studied in a rat isolated perfused lung model. The left lungs were fixed for electron microscopy by vascular perfusion either immediately after excision (control; n = 5) or after perfusion with modified Euro-Collins solution (EC), storage for 2 h at 4 ° C in EC, and reperfusion for 40 min (n = 5). A stereological approach was chosen to discriminate between intraalveolar surfactant subtypes of edematous regions and regions free of edema. Intraalveolar edema seen after I/R in the EC group occupied 36 ± 6% (mean ± SEM) of the gas exchange region as compared with control lungs (1 ± 1%; p = 0.008). Relative intraalveolar surfactant composition showed a decrease in surface active tubular myelin (3 ± 1 versus 12 ± 0%; p = 0.008) and an increase in inactive unilamellar forms (83 ± 2 versus 64 ± 5%; p = 0.008) in the EC group. These changes occurred both in edematous (tubular myelin, 3 ± 1%; unilamellar forms, 88 ± 6%) and in nonedematous regions (tubular myelin, 4 ± 3%; unilamellar forms, 77 ± 5%). The ultrastructural changes in surfactant were associated with an increase in peak inspiratory pressure during reperfusion. In conclusion, surfactant alterations seen after I/R are not directly related to the presence of edema fluid in the alveoli. Disturbances in intraalveolar surfactant after I/R are not merely the result of inactivation due to plasma protein leakage but may instead be responsible for an increased permeability of the blood–air barrier, resulting in a vicious cycle of intraalveolar edema formation and progressing surfactant impairment.