tbuckley/cabot-search huggingface dataset:
Crime Committed During Epileptic Seizure
Authors: Howard Newcomb
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
779 BASELINE FACTORS ASSOCIATED WITH RAPID AND EARLY VIROLOGICAL RESPONSES IN HCV GENOTYPE 1 PATIENTS TREATED WITH INDUCTION DOSING OF PEGYLATED INTERFERON: THE CHARIOT STUDY
Authors: D.H.G. Crawford, S. Roberts, M. Weltman, W.S.C. Cheng, W. Sievert, G. McCaughan, P. Desmond, A.W. Alston, J. DePamphilis, P. Marks, G.J. Dore
Journal: Journal of Hepatology (2008)
Nuclear medicine and the nursing mother.
Authors: A J Coakley, P J Mountford
Journal: BMJ (1985)

Nuclear medicine and the nursing mother When nuclear medicine investigations are requested for women who are breast feeding they present a potential hazard to the infant both from radiation and from pharmaceuticals transmitted in the breast milk.Cases have been described of babies drinking radioactive milk and more have probably gone unreported.`3On the other hand, undue anxiety about the problems may deter clinicians from requesting investigations.How great are the hazards, and what can be done to reduce them?Many radiopharmaceuticals may be detected in breast milk.4These substances differ from other drugs in that for diagnostic purposes they are used in tracer quantities and do not produce demonstrable pharmacological changes in the mother or infant.Patients may also be given non-radioactive drugs to induce changes in the distribution of the radiopharmaceuticals, and some of these, too, appear in milk.68Drugs used in this way include frusemide, potassium perchlorate, iodides, and cholecystokinin.Iodides are selectively con- centrated in breast milk, and some consider them contraindicated during lactation.4Assessment of risks from the other agents is difficult because of lack of data, though the amounts of frusemide that appear in milk seem unlikely to be pharmacologically important.49The more obvious topic of concern is with radiation, which may be transmitted directly from the mother when cuddling and at feeding or be ingested in the milk.There are no standards for evaluating a radiation hazard specifically in infants.The measures used in practice are the dose equivalent
Use of Tissue Velocity Imaging in the Diagnosis of Fetal Cardiac Arrhythmias
Authors: A.J.J.T. Rein, C. O’Donnell, T. Geva, A. Nir, Z. Perles, I. Hashimoto, X.-K. Li, D.J. Sahn
Journal: Circulation (2002)

Precise diagnosis of cardiac arrhythmias in the fetus is crucial for a managed therapeutic approach. However, many technical, positional, and gestational age-related limitations may render conventional methods, such as M-mode and Doppler flow methodologies, or newer techniques, such as fetal electrocardiography or magnetocardiography, difficult to apply, or these techniques may be unsuitable for the diagnosis of fetal arrhythmias.In this prospective study, we describe a novel method based on raw scan-line tissue velocity data acquisition and analysis. The raw data are available from high-frame-rate 2D tissue velocity images and allow simultaneous sampling of right and left atrial and ventricular wall velocities to yield precise temporal analysis of atrial and ventricular events. Using this timing data, a ladder diagram-like "fetal kinetocardiogram" was developed to diagram and diagnose arrhythmias and to provide true intervals. This technique was feasible and fast, yielding diagnostic results in all 31 fetuses from 18 to 38 weeks of gestation. Analysis of various supraventricular and ventricular arrhythmias was readily obtained, including arrhythmias that conventional methods fail to diagnose.The fetal kinetocardiogram opens a new window to aid in the diagnosis and understanding of fetal arrhythmias, and it provides a tool for studying the action of antiarrhythmic drugs and their effects on electrophysiological conduction in the fetal heart.
THE CARE AND TREATMENT OF INEBRIATES.
Authors: GEORGE F. BUTLER
Journal: JAMA (1907)

The therapeusis of inebriety turns like that of any other morbid condition on the definition of inebriety. In such conditions the relative element is largely involved, not merely as to quantity drunk, but also as to the character of the individual affected. Drunkenness is an old condition and made its appearance early in evolution among the social animals. Bees, wasps and ants become intoxicated on fruit ferments and recover from the intoxication with apparently the same experience of exhaustion as the human being. There is hardly a race which has not, independently of all others, obtained a method of intoxication, varying from the use of fungi, as is the case with certain Siberian aborigines, to that of distilled liquors. Distilled liquors were at first comparatively rare as a means of intoxication, and under the title of essences were sold almost entirely by druggists. With the development of the gin industry
RGD-FasL Induces Apoptosis in Hepatocellular Carcinoma
Authors: Zhongchen Liu, Juan Wang, Ping Yin, Jinhua Qiu, Ruizhen Liu, Wenzhu Li, Xin Fan, Xiaofeng Cheng, Caixia Chen, Jiakai Zhang, Guohong Zhuang
Journal: Cellular and Molecular Immunology (2009)
Staphylococcus aureus bacteraemia: 400 episodes in St Thomas's Hospital.
Authors: W R Gransden, S J Eykyn, I Phillips
Journal: BMJ (1984)

Four hundred episodes of Staphylococcus aureus bacteraemia occurred in St Thomas's Hospital from 1969 to 1983, accounting for 17.5% of all episodes of bacteraemia. The mortality was 24%, half attributable to underlying disease, and was highest in patients over 50. Almost 60% of the bacteraemias were acquired in hospital, and the source of the organism was generally obvious, with vascular access sites the most common (37%). Bone and joint infections accounted for 11.5% of episodes and endocarditis for 7%. Most staphylococci were resistant to penicillin only; three isolates were resistant to methicillin and five to fusidic acid. Microbiologists seldom influenced directly the choice of initial antibiotic treatment (though this usually conformed to the hospital's antibiotic prescribing policy) but had considerable influence over definitive treatment, usually cloxacillin or flucloxacillin alone or in combination with fusidic acid. S aureus bacteraemia is easy to identify and treat, though underlying disease may influence the outcome. Efforts should be made to prevent the largely iatrogenic disease.
Endothelin in plasma and cerebrospinal fluid of patients with subarachnoid haemorrhage
Authors: Akira Fujimori, Masashi Yanagisawa, Akira Saito, Katsutoshi Goto, Tomoh Masaki, Tatsuo Mima, Kintomo Takakura, Taku Shigeno
Journal: The Lancet (1990)
Leadership Switch in Congress
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A case of disseminated granuloma annulare treated with defibrotide: complete clinical remission and progressive hair darkening
Authors: P. Rubegni, P. Sbano, M. Fimiani
Journal: British Journal of Dermatology (2003)

Journal Article A case of disseminated granuloma annulare treated with defibrotide: complete clinical remission and progressive hair darkening Get access P. Rubegni, P. Rubegni Istituto di Scienze Dermatologiche, Università degli Studi di Siena, Policlinico 'Le Scotte', Viale Bracci, 53100 Siena, Italy E‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar P. Sbano, P. Sbano Istituto di Scienze Dermatologiche, Università degli Studi di Siena, Policlinico 'Le Scotte', Viale Bracci, 53100 Siena, Italy E‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar M. Fimiani M. Fimiani Istituto di Scienze Dermatologiche, Università degli Studi di Siena, Policlinico 'Le Scotte', Viale Bracci, 53100 Siena, Italy E‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 2, 1 August 2003, Pages 437–439, https://doi.org/10.1046/j.1365-2133.2003.05462.x Published: 01 August 2003
Biomechanical properties of reperfused transmural myocardial infarcts in rabbits during the first week after infarction. Implications for left ventricular rupture.
Authors: C M Connelly, S Ngoy, F J Schoen, C S Apstein
Journal: Circulation Research (1992)

Left ventricular (LV) rupture potential was studied after transmural myocardial infarction (MI) in rabbits by measuring 1) the tensile strength of infarcted tissue strips, 2) the force required to initiate a tear (tear threshold) in the central infarcted region, and 3) the intracavitary pressure required to rupture the infarcted ventricle. During the first week after MI, infarcts resulting from a permanent coronary occlusion were compared with infarcts reperfused "late" (i.e., 3 hours) after coronary occlusion with a resultant hemorrhagic transmural infarct but no reduction in infarct size. The reperfused hemorrhagic infarcted strips had less tensile strength than strips from permanently occluded infarcts in the initial 24 hours after MI (16 +/- 1 versus 24 +/- 3 g/mm2, p less than 0.05), but the tear threshold and response to increased LV pressure were not influenced by infarct reperfusion at this time. By 3 days after MI, reperfused infarcts had equal tensile strength, had greater resistance to infarct tearing, and could withstand a greater LV distending pressure compared with permanently occluded infarcts. By 5 days after MI, reperfused infarcts maintained a greater tear threshold but had less tensile strength than permanently occluded infarcts, although all infarct values were equivalent or greater than normal LV values. By 7 days after MI, reperfused and permanently occluded infarcts were equally strong by all measurements. Thus, late reperfusion of transmural infarcts increased resistance to infarct tearing and LV rupture above that of nonreperfused permanently occluded infarcts by 3 days after MI and enhanced tissue strength after an initial 24-hour vulnerable period. These findings suggest that late reperfusion may accelerate myocardial healing after MI.
Helping pensioners to keep warm.
Authors: D Donnison
Journal: BMJ (1977)

<h3>Background</h3> Forkhead box O (FoxO) transcription factors integrate environmental signals to modulate cell proliferation and survival, and alterations in FoxO function have been reported in rheumatoid arthritis (RA). <h3>Objectives</h3> To examine the relationship between inflammation and FoxO expression in RA, and to analyse the mechanisms and biological consequences of FoxO regulation in RA fibroblast-like synoviocytes (FLS). <h3>Methods</h3> RNA was isolated from RA patient and healthy donor (HD) peripheral blood and RA synovial tissue. Expression of FoxO1, FoxO3a and FoxO4 was measured by quantitative PCR. FoxO1 DNA binding, expression and mRNA stability in RA FLS were measured by ELISA-based assays, immunoblotting and quantitative PCR. FLS were transduced with adenovirus encoding constitutively active FoxO1 (FoxO1ADA) or transfected with small interfering RNA targeting FoxO1 to examine the effects on cell viability and gene expression. <h3>Results</h3> FoxO1 mRNA levels were reduced in RA patient peripheral blood compared with HD blood, and RA synovial tissue FoxO1 expression correlated negatively with disease activity. RA FLS stimulation with interleukin 1β or tumour necrosis factor caused rapid downregulation of FoxO1. This effect was independent of protein kinase B (PKB), but dependent on c-Jun N-terminal kinase (JNK)-mediated acceleration of FoxO1 mRNA degradation. FoxO1ADA overexpression in RA FLS induced apoptosis associated with altered expression of genes regulating cell cycle and survival, including BIM, p27<sup>Kip1</sup> and Bcl-XL. <h3>Conclusions</h3> Our findings identify JNK-dependent modulation of mRNA stability as an important PKB-independent mechanism underlying FoxO1 regulation by cytokines, and suggest that reduced FoxO1 expression is required to promote FLS survival in RA.
Anaerobic glycolysis and the development of ischaemic contracture in isolated rat heart
Authors: J. A LIPASTI, T. J NEVALAINEN, K. A ALANEN, M. A TOLVANEN
Journal: Cardiovascular Research (1984)

The relationship between myocardial ATP content and the increase in left ventricular resting tension during ischaemia (ischaemic contracture) was studied in isolated rat hearts perfused for 15 min either with aerobic buffer (pO2>500 mmHg) containing non-glycolytic substrate, acetate (5 mmol·litre−1), or with hypoxic buffer (pO2< 10 mmHg) with glucose (10 mmol·litre−1) before making them totally ischaemic for 10 min. ATP was determined spectrophotometrically from extracts of frozen whole hearts. Left ventricular tension was recorded by intraventricular balloon catheter. Myocardial ATP content was 15.4±1.0 μmol·g−1 dry weight μmol·g−1) after 10 min stabilising period, 14.1±0.9 μmol·g−1 after 15 min aerobic perfusion (plus acetate) and 9.0±1.3 μmol·g−1 after 15 min hypoxic perfusion (plus glucose). During 10 min of ischaemia ATP decreased in aerobic hearts to 5.4 ± 1.1 μmol·g−1 and to 7.9 ± 1.0 μmol·g−1 in hypoxic hearts. The left ventricular resting tension increased during ischaemia in hypoxic hearts to 9±5% of control systolic pressure (0=diastolic pressure, 100=systolic pressure during stabilising period), whereas in aerobic hearts the tension began to increase immediately and was 84±22% of systolic pressure at the end of the ischaemic period. In parallel control experiments, hearts were also perfused either with glucose-containing aerobic buffer or acetate-containing hypoxic buffer. ATP was well preserved during aerobic perfusion (plus glucose) but decreased markedly during hypoxic perfusion (plus acetate). There was no increase in resting tension in the aerobic hearts (plus glucose) whereas the resting tension increased considerably during hypoxic perfusion (plus acetate). The results indicate that the initiation of ischaemic contracture occurs at much higher myocardial ATP level when ATP comes from mitochondrial sources than when ATP is generated by anaerobic glycolysis. The difference may be due to intracellular compartmentalisation of ATP providing different amounts of ATP available for contractile proteins or for cellular membranes to maintain calcium homeostasis.
Improving the mental health of offenders in primary care
Authors: Gill Mezey
Journal: BMJ (2007)

Strategies to enhance social inclusion are as important as medical interventions 

According to a recent MORI poll, doctors are viewed by the public as the most trusted professionals; more than 90% of the public trust doctors to be truthful and 80% view them as helpful.1 However, a qualitative study reported in this week's BMJ by Howerton and colleagues found that most offenders did not trust their general practitioners enough to ask them for help, despite experiencing high levels of distress, self harming behaviour, and emotional problems.2 

Childhood abuse and early traumatic life events are associated with increased rates of neurotic disorders, including post-traumatic stress disorder, substance misuse, self harm, and antisocial personality disorder in adulthood.3 4 Survivors of abuse have problems in trusting others (particularly figures in authority), and both victims and perpetrators of crime commonly have feelings of low self esteem, shame, and helplessness.5 6 Male prisoners have high rates of lifetime traumatic experiences,2 3 4 and not surprisingly these “offender-victims” experience high levels of psychological distress, yet are reluctant to seek help from health professionals. 

Even in the general …
Student Loan Deferment: The Past, Present, and Precarious Future
Authors: Douglas P. Beall
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outbreak of Hypersensitivity Pneumonitis in an Industrial Setting
Authors: Elizabeth D. Woodard
Journal: JAMA (1988)

Symptoms consistent with hypersensitivity pneumonitis developed in several workers in two multistory buildings in an industrial complex. A health questionnaire survey was conducted to determine the extent of the problem. Eighty-seven percent of the population of 1050 employees completed the health questionnaire. Serological testing identified 152 positive precipitin reactors to the fungus<i>Aureobasidium pullulans</i>; 115 reactors were symptomatic. The clinical and laboratory features at the time of the acute illness and during four years of follow-up are described. The agent,<i>A pullulans</i>, was identified as a contaminant of the heating-cooling ventilation units containing open water-spray chambers. Control was accomplished by replacement of the ventilation systems. A secondary source of antigen was found to be corrugated cardboard. Some sensitized employees required removal from work exposure to corrugated cardboard to prevent recurrent symptoms. (<i>JAMA</i>1988;259:1965-1969)
Response to A. G. Helg's comments on the LEGS study
Authors: Marlene Fransen, Richard O Day
Journal: Annals of the Rheumatic Diseases (2014)

The comments expressed by Dr Helg1 are directed at attributing the lack of symptomatic or structural benefit detected in the LEGS study for the single treatment allocations (chondroitin sulfate or glucosamine sulfate alone) to issues of study methodology.2

Dr Helg attempts to give the impression that the considered and documented change to the primary outcome was precipitate. The change of primary outcome to the maximum score of pain ‘at its worst’ reported daily for 7 days each 2 months in a participant diary with a Numerical Rating Scale (NRS) was justified in the discussion: “We had originally stated in the study registration that reduction in the use of NSAIDs would be the main symptomatic outcome measure. Our main symptomatic outcome measure was changed (and registered) to self-reported pain after recruitment of the first 200 participants demonstrated that only about 20% were using NSAIDs. Further, we felt that the specific focus of knee pain (‘at its worst’) for the daily 7-day numeric rating scale of the participant diary would be less vulnerable to a ‘floor effect’ among our study participants with mostly mild radiographic disease, and more likely to detect the ‘short episodes of more intense pain 'experienced by many people with knee OA.3 Interestingly, the mean WOMAC pain scores at baseline were low compared with the numeric rating scale scores, possibly precluding the detection of treatment benefit using this measure in a mildly symptomatic population.”

It was suggested that …
Photochemotherapy and Psoriatic Arthritis
Authors: SUSAN G. PERLMAN
Journal: Annals of Internal Medicine (1979)

We have studied the temporal relation between psoriasis and psoriatic arthritis in 27 patients receiving photochemotherapy for treatment of psoriasis. Patients were classified as either spondylitic or nonspondylitic. For spondylitic patients, psoriasis was difficult to control, arthritis did not improve, and skin and joint activity appeared to vary independently. In contrast, 67% of nonspondylitic patients receiving photochemotherapy treatment remained clear of psoriasis, with 49% mean improvement in articular index. There was an inverse relation between initial percentage of psoriasis and improvement in peripheral arthritis. These results suggest that aggressive management of psoriasis helps control synovitis in at least a subgroup of patients with psoriatic arthritis.
Prevalence of actinic keratosis among dermatology outpatients in Austria
Authors: J. Eder, K. Prillinger, A. Korn, A. Geroldinger, F. Trautinger
Journal: British Journal of Dermatology (2014)

Actinic keratoses (AKs) are common precursors of squamous cell carcinomas (SCCs) of the skin making them an important public health issue with information on their prevalence widely lacking.To define the prevalence of AK in dermatology outpatients in Austria and to identify more accurately the target population for AK screening, treatment and prevention.Each of the 48 randomly selected Austrian office-based dermatologists simultaneously screened 100 consecutive patients (aged ≥ 30 years) for the presence of AK.In total, 4449 evaluable patients showed an overall AK prevalence of 31·0%, which was higher in men (39·2%) than in women (24·3%) and increased with age in both sexes. AK distribution among sun-exposed body sites and extent of disease varied with sex and region.In Austria, AKs are common among dermatology outpatients, who have access to professional education and treatment. Investigations regarding the efficacy of routine AK screening in dermatology outpatients for the prevention of invasive SCC is warranted.