tbuckley/cabot-search huggingface dataset:
Variant Angina of Printzmetal with Normal Coronary Arteriograms: A Variant of the Variant.
Authors: Tsung O. Cheng
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Variant Angina of Printzmetal with Normal Coronary Arteriograms: A Variant of the Variant.Tsung O. Cheng, M.D., F.A.C.P., T. Bashour, M.D., G. A. Kelser, M.D., F.A.C.P., L. Weiss, M.D., J. Bacos, M.D., F.A.C.P.Tsung O. Cheng, M.D., F.A.C.P., T. Bashour, M.D., G. A. Kelser, M.D., F.A.C.P., L. Weiss, M.D., J. Bacos, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-862_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVariant angina of Prinzmetal has been generally thought to be caused by a focal stenotic lesion of a major coronary artery, which should be an ideal lesion for saphenous-vein graft bypass. Recognition of this syndrome would then be of particular diagnostic and therapeutic importance if such a consistent association can be demonstrated. Four patients with typical variant angina who had normal coronary arteriograms are reported. A number of observations in these four patients raised pertinent questions about the nature of this syndrome, the pathogenesis of angina, and the therapeutic implications. In common with Prinzmetal's original description, all four patients had... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardiac Migraine—Report of Twelve CasesVariant angina pectoris caused by coronary artery spasmNonocclusive Coronary Disease Associated with Prinzmetal's Angina PectorisAngina Pectoris at Rest with Preservation of Exercise CapacityMyocardial infarction in the absence of coronary arteriosclerosis 1 May 1972Volume 76, Issue 5Page: 862-862KeywordsAnginaCoronary arteriesLesionsPathogenesisStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function
Authors: Francesca R. Santoni de Sio, Joanna Massacand, Isabelle Barde, Sandra Offner, Andrea Corsinotti, Adamandia Kapopoulou, Karolina Bojkowska, Antonis Dagklis, Marylise Fernandez, Paolo Ghia, James H. Thomas, Daniel Pinschewer, Nicola Harris, Didier Trono
Journal: Blood (2012)
Left Ventricular Wall Movement in Heart Failure
Authors: P. Carson, L. Kanter
Journal: BMJ (1971)

Of 34 patients admitted to hospital with left ventricular failure seven died before echocardiograms could be repeated after treatment and in three no echocardiograms could be obtained owing to chronic obstructive lung disease. In the remaining 24 patients echocardiograms were taken soon after admission and compared with echocardiograms taken later, after clinical improvement. The results show that in most patients both anterior and posterior motion of the posterior left ventricular wall increased. The rate of backward diastolic motion was appreciably less before and after treatment of heart failure compared with that in a small group of normal younger healthy men. This technique is a quick and apparently reliable way to assess ventricular function. The rate of diastolic motion is probably a reflection of left ventricular wall compliance.
US gets mediocre results despite high spending on health care
Authors: Janice Tanne
Journal: BMJ (2006)

The United States spends twice as much on health care as a percentage of gross domestic product as other industrialised countries, a new report says. But it is behind the other countries in providing its citizens with good health outcomes, quality of care, access to care, efficiency, and equity, the report concludes.

The report, from the Commonwealth Fund, a private, non-profit foundation that works to increase healthcare coverage and quality, says: “Although national health spending is significantly higher than the average rate of other industrialized countries, the US is the only industrialized country that fails to guarantee universal health insurance, and coverage is deteriorating, leaving millions without affordable access to preventive and essential care.

“Quality of care is highly variable and delivered by a system that is too often poorly coordinated, driving up costs and putting patients at risk.”

The …
Posttranscriptional Regulation of BK Channel Splice Variant Stability by miR-9 Underlies Neuroadaptation to Alcohol
Authors: Andrzej Z. Pietrzykowski, Ryan M. Friesen, Gilles E. Martin, Sylvie I. Puig, Cheryl L. Nowak, Patricia M. Wynne, Hava T. Siegelmann, Steven N. Treistman
Journal: Neuron (2008)
Technetium-99m Particle Imaging: Acquired Pulmonary Micro-Arteriovenous Fistulae
Authors: JOHN R. STY, ROBERT G. WELLS
Journal: Clinical Nuclear Medicine (1989)

A 6-year-old boy with biliary cirrhosis developed cyanosis acutely. The child had a history of biliary atresia, and a Kasai procedure was performed during infancy. The chest radiograph demonstrated a new reticulonodular interstitial pulmonary pattern. Technetium-99m macro-aggregated albumin lung imaging was performed to determine if intrapuimonary vascular malformations were a complicating factor in the child with chronic liver disease. The lung image documented intrapulmonary fistulae. This is a rare complication in surviving children with biliary atresia. This case illustrates the value of Tc-99m particle imaging in this condition.
Psychiatric status and 9-year mortality data in the New Haven Epidemiologic Catchment Area Study
Authors: Martha Livingston Bruce, Philip J. Leaf, Gregory Paul M. Rozal, Louis Florio, Rani A. Hoff
Journal: American Journal of Psychiatry (1994)

This study examined the effects of nine axis I psychiatric disorders, as assessed by the Diagnostic Interview Schedule, on the risk of mortality over a 9-year period among a community sample of 3,560 men and women aged 40 and older.The study identified the vital status as of Oct. 1, 1989, of respondents who were first interviewed in 1980 by the New Haven Epidemiologic Catchment Area study. Mortality risk by psychiatric status was estimated by using Cox proportional hazards models.Nine years after the baseline interview, it was confirmed that 1,194 (33.5%) of the respondents were deceased and 2,344 (65.8%) survived; the vital status of 22 (0.6%) remained unknown. When the relative risk of mortality was adjusted for age, several disorders--major depression, alcohol abuse or dependence, and schizophrenia--increased the likelihood of mortality.These data are further evidence of the negative outcome of some psychiatric problems even when assessed in community samples. The relatively high prevalence of depression and alcohol disorders indicates the far-reaching impact that these problems have on community health in general.
THE EXPERIMENTAL PATHOLOGY OF CANCER
Authors: FRANCIS CARTER WOOD
Journal: JAMA (1925)

The experimental study of cancer in a real sense began about 1900 with the discoveries of Jensen and Loeb concerning the relatively easy transplantability of certain spontaneous tumors of mice and rats from one animal to another. This, like most other discoveries, had long been anticipated, though Jensen's thorough investigations still stand today as a model of scientific achievement. <h3>METHODS AND CONDITIONS OF TRANSPLANTATION</h3> The methods and conditions that underlie such transplantation are still too little known, even to pathologists. The preferable technic was found years ago to be the grafting into the subcutaneous tissue of the axilla of the animal of a very small tumor fragment weighing only a few milligrams, by means of a trocar and cannula. The syringe injection of a mush of tumor cells is often followed by growths, but is not so satisfactory as the trocar method. Once the tumor particle is deposited in the
Bronchoscopy-associated Mycobacterium xenopi pseudoinfections.
Authors: S N Bennett, D E Peterson, D R Johnson, W N Hall, B Robinson-Dunn, S Dietrich
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Mycobacterium xenopi typically accounts for less than 0.3% of all clinical mycobacterial isolates. Over a 37-mo period, 21 (35%) of 60 mycobacterial isolates from a Michigan hospital were identified as M. xenopi. Hospital, laboratory, and bronchoscopy records were reviewed to determine case characteristics, develop a case series, and calculate procedure-specific M. xenopi isolation rates. A case-control study was conducted to elucidate aspects of the bronchoscopy procedure associated with M. xenopi isolation. Bronchoscope cleaning procedures were reviewed, and hospital water systems were cultured. Four isolates were from three patients with disease attributable to M. xenopi. Of the other isolates, specimens obtained by bronchoscopy were more likely to yield M. xenopi than were specimens obtained by other routes (relative risk, 9.7; 95% confidence intervals, 3.2, 29.6). Bronchoscopes were disinfected in a 0.13% glutaraldehyde-phenate and tap-water bath and then were rinsed in tap water. Water from the hot water tank supplying this area yielded M. xenopi. Mycobacteria were cultured from bronchoscopes after disinfection. M. xenopi in the tap water appears to have contaminated the bronchoscopes during cleaning. Adequate disinfection of contaminated bronchoscopes and careful collection of specimens to avoid contamination with contaminated water are essential, both for limiting diagnostic confusion caused by mycobacterial pseudoinfections and for reducing risks of disease transmission.
Post-analysis follow-up and validation of microarray experiments
Authors: Rodrigo F. Chuaqui, Robert F. Bonner, Carolyn J.M. Best, John W. Gillespie, Michael J. Flaig, Stephen M. Hewitt, John L. Phillips, David B. Krizman, Michael A. Tangrea, Mamoun Ahram, W. Marston Linehan, Vladimir Knezevic, Michael R. Emmert-Buck
Journal: Nature Genetics (2002)
Importance of Markers in Tc-99m Pyrophosphate Myocardial Images
Authors: PRASAN J. VASAVADA, TIMOTHY J. MICKLOS, HIROSHI NISHIYAMA
Journal: Clinical Nuclear Medicine (1985)

A false-positive Tc-99m PYP myocardial scan may result due to gastric activity from breakdown of radiopharmaceutlcal and accumulation of Tc-99m pertechnetate in gastric cells. Importance of anatomic landmarks during early blood pool images is emphasized to prevent this error.
Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure?
Authors: Thomas Eschenhagen
Journal: Journal of Clinical Investigation (2010)

In situations of stress the heart beats faster and stronger. According to Marks and colleagues, this response is, to a large extent, the consequence of facilitated Ca2+ release from intracellular Ca2+ stores via ryanodine receptor 2 (RyR2), thought to be due to catecholamine-induced increases in RyR2 phosphorylation at serine 2808 (S2808). If catecholamine stimulation is sustained (for example, as occurs in heart failure), RyR2 becomes hyperphosphorylated and "leaky," leading to arrhythmias and other pathology. This "leaky RyR2 hypothesis" is highly controversial. In this issue of the JCI, Marks and colleagues report on two new mouse lines with mutations in S2808 that provide strong evidence supporting their theory. Moreover, the experiments revealed an influence of redox modifications of RyR2 that may account for some discrepancies in the field.
A Comparative Study of Fused FDG PET/MRI, PET/CT, MRI, and CT Imaging for Assessing Surrounding Tissue Invasion of Advanced Buccal Squamous Cell Carcinoma
Authors: Shu-Hua Huang, Chi-Yen Chien, Wei-Che Lin, Fu-Min Fang, Pei-Wen Wang, Chun-Chung Lui, Yung-Cheng Huang, Bor-Tau Hung, Min-Chien Tu, Chiung-Chih Chang
Journal: Clinical Nuclear Medicine (2011)

This study aimed to evaluate the diagnostic value of fused fluorodeoxyglucose positron emission tomography and magnetic resonance imaging (PET/MRI) compared with PET/computed tomography (CT), MRI, and CT in assessing surrounding tissue invasion of advanced buccal squamous cell carcinoma (BSCC).PET/CT and MRI were performed in 17 consecutive patients with suspected masticator space invasion of BSCC from CT images. Attenuation-corrected PET and head and neck MRI datasets were registered. For pathologic correlation, 4 regions of interest were examined, including the maxilla, mandible, pterygoid, and masseter muscle. The tumor maximal diameter, measured by different imaging modalities, was correlated with pathology results.All PET/MRI fusions were verified as well matched using specific anatomic criteria. For pathology results, 1 patient had inflammation only, 1 had spindle cell cancer, and 15 had squamous cell cancer. Of 64 regions of interest, 20 (31.3%) harbored tumor invasion. The likelihood ratio was highest in fused PET/MRI (42.56) compared with PET/CT (25.02), MRI (22.94), and CT (8.6; all P < 0.05). The sensitivity and specificity of fused PET/MRI were also highest among the 4 modalities (90.0%/90.9%, 80.0%/84.1%, 80.0%/79.5%, and 55.0%/81.8%, respectively). The level of confidence was higher in fused PET/MRI or MRI than in PET/CT or CT (85.9%, 85.9%, 70.3%, 73.4%, respectively). The maximal lesion size was 3.0 to 6.0 cm in the pathology specimen. Regression analysis showed better agreement between fused PET/MRI and pathology results.Fused PET/MRI is more reliable for focal invasion assessment and tumor size delineation in advanced BSCC compared with PET/CT, MRI, and CT. PET/CT has the lowest confidence level, which may limit its use in the clinical setting.
Hypertensive encephalopathy and the blood-brain barrier: is δPKC a gatekeeper?
Authors: Wen-Hai Chou, Robert O. Messing
Journal: Journal of Clinical Investigation (2007)

Hypertensive encephalopathy is a life-threatening condition due to elevation of cerebral perfusion pressure beyond the limits of autoregulation. Breakdown of the blood-brain barrier (BBB) leads to cerebral edema and reduced blood flow. In this issue of the JCI, Mochly-Rosen and colleagues demonstrate a novel molecular strategy for preserving the BBB in a model of hypertension-induced encephalopathy (see the related article beginning on page 173). Using a rationally designed peptide inhibitor of deltaPKC, they stabilized the BBB and improved mortality in hypertensive rats. This study highlights the therapeutic potential of deltaPKC inhibitors in hypertensive encephalopathy and provides incentive to elucidate deltaPKC signaling pathways that mediate BBB dysfunction in other disease states.
Functional Relaxation and Guided Imagery as Complementary Therapy in Asthma: A Randomized Controlled Clinical Trial
Authors: C. Lahmann, M. Nickel, T. Schuster, N. Sauer, J. Ronel, M. Noll-Hussong, K. Tritt, D. Nowak, F. Röhricht, T. Loew
Journal: Psychotherapy and Psychosomatics (2009)

&lt;i&gt;Background:&lt;/i&gt; Asthma is a frequently disabling and almost invariably distressing disease that has a high overall prevalence. Although relaxation techniques and hypnotherapeutic interventions have proven their effectiveness in numerous trials, relaxation therapies are still not recommended in treatment guidelines due to a lack of methodological quality in many of the trials. Therefore, this study aims to investigate the efficacy of the brief relaxation technique of functional relaxation (FR) and guided imagery (GI) in adult asthmatics in a randomized controlled trial. &lt;i&gt;Methods:&lt;/i&gt; 64 patients with extrinsic bronchial asthma were treated over a 4-week period and assessed at baseline, after treatment and after 4 months, for follow-up. 16 patients completed FR, 14 GI, 15 both FR and GI (FR/GI) and 13 received a placebo relaxation technique as the control intervention (CI). The forced expiratory volume in the first second (FEV&lt;sub&gt;1&lt;/sub&gt;) as well as the specific airway resistance (sR&lt;sub&gt;aw&lt;/sub&gt;) were employed as primary outcome measures. &lt;i&gt;Results:&lt;/i&gt; Participation in FR, GI and FR/GI led to increases in FEV&lt;sub&gt;1&lt;/sub&gt; (% predicted) of 7.6 ± 13.2, 3.3 ± 9.8, and 8.3 ± 21.0, respectively, as compared to –1.8 ± 11.1 in the CI group at the end of the therapy. After follow-up, the increases in FEV&lt;sub&gt;1&lt;/sub&gt; were 6.9 ± 10.3 in the FR group, 4.4 ± 7.3 in the GI and 4.5 ± 8.1 in the FR/GI, compared to –2.8 ± 9.2 in the CI. Improvements in sR&lt;sub&gt;aw&lt;/sub&gt; (% predicted) were in keeping with the changes in FEV&lt;sub&gt;1&lt;/sub&gt; in all groups. &lt;i&gt;Conclusions:&lt;/i&gt; Our study confirms a positive effect of FR on respiratory parameters and suggests a clinically relevant long-term benefit from FR as a nonpharmacological and complementary therapy treatment option.
Unwise Tenement-House Legislation
Authors: Henry Atterbury Smit
Journal: JAMA (1913)

<h3>To the Editor:</h3> —Your editorial discussion in last week's issue (p. 52) of tenement legislation prompts me to add these coniderations. Rents are high on Manhattan Island because the demand for space in which to live is beyond the supply. Also the rent is artificially and unnecessarly made still more prohibitive by two recent measures offered by the Charity Organization Sociey, and made a law April, 1912. The first measure was a requirement that the water-closet in the Vanderbilt tenement, and in fact in all the open-stair tenements, and in future buildings of that type should be placed on the valuable and limited outside wall space known as the periphery, whereas adequate ventilation and lighting was provided for the water-closet on the "court stair recess" through a window, view-proof even when open. The New York Academy of Medicine, the Tenement Economies Society and many other societies, as well as individuals, regret this added load on the small wage-earner. This alone is prohibitive, probably adding 12 per cent, to the already high rent.
Role of interleukin-30 as a modulator of transcription signaling in liver injury
Authors: Tetsuji Fujita
Journal: Hepatology (2012)

Dr. Dibra and colleagues1 demonstrated that interleukin (IL)-30 reduced hepatotoxicity through the downregulation of interferon (IFN)-γ in a mouse model of T cell-mediated hepatitis. These findings suggest that IL-30 therapy may represent a promising strategy to minimize liver damage in several clinical settings. However, there is conflicting evidence that IL-30 may enhance liver injury through the suppression of IL-6/glycoprotein (gp) 130/signal transducer and activator of transcription (STAT) 3 signaling. In a study of hepatocyte-specific gp130 knockout mice, IL-6/gp130/STAT3 signaling ameliorated liver injury in concanavalin A-induced hepatitis.2 Also, in a study of macrophage/neutrophil-specific gp130 knockout mice, deletion of gp130 significantly decreased release of IL-6 from immune cells and was associated with more severe liver injury of concanavalin A hepatitis.3 In IL-10–deficient mice, additional deletion of IL-6 or STAT3 resulted in hepatic steatosis and the elevation of serum alanine aminotransferase.4 Thus, activation of IL-6/gp130/STAT3 signaling plays an important role in protecting against liver injury, whereas IL-30 inhibited interaction of IL-6 with gp130 and decreased IL-6–mediated production of IL-10 in a dose-dependent manner.5 Does IL-30 suppress the production of IFN-γ at the cellular or molecular level? IL-27 is composed of IL-27p28 (IL-30), Epstein-Barr virus-induced gene 3 (EBI3), and an IL-6-like protein. Each subunit of IL-27 may be secreted independently and may share the T cell cytokine receptor (TCCR). IL-27/EBI3-deficient mice were protected from concanavalin A-induced liver injury through the downregulation of IFN-γ.6 IL-30 may function as an EBI3 antagonist by competing binding to TCCR, wherein overall effect of IL-30 in liver injury may be dependent on the balance between IL-30 and IL-27 or EBI3. Tetsuji Fujita M.D.*, * Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
Ca2+ Signaling via the Neuronal Calcium Sensor-1 Regulates Associative Learning and Memory in C. elegans
Authors: Marie Gomez, Edouard De Castro, Ernesto Guarin, Hiroyuki Sasakura, Atsushi Kuhara, Ikue Mori, Tamas Bartfai, Cornelia I Bargmann, Patrick Nef
Journal: Neuron (2001)
The comparison with juniper/cedar pollen counting and the pollinosis patients in Fukuoka city, Japan, and Galveston, Texas
Authors: R. Kishikawa, P.D. Jantzi, T.M. Horiuti, R.M. Goldblum, E. Koto, T. Shimoda, S. Shoji, E.G. Brooks, S. Nishima
Journal: Journal of Allergy and Clinical Immunology (2005)
Potential Use of a Caspase Against HIV
Authors: Terri H. Finkel
Journal: JAMA (1999)

At present, treatment of HIV infection uses small inhibitory molecules
that target HIV protease; however, the emergence of resistant HIV strains
is increasingly problematic. To circumvent this, we report here a new ‘Trojan
horse' strategy to kill HIV-infected cells by exploiting HIV protease. We
engineered a transducing, modified, apoptosis-promoting caspase-3 protein,
TAT–Casp3, that substitutes HIV proteolytic cleavage sites for endogenous
ones and efficiently transduces about 100% of cells, but remains inactive
in uninfected cells. In HIV-infected cells, TAT–Casp3 becomes processed
into an active form by HIV protease, resulting in apoptosis of the infected
cell. This strategy could also be applied to other pathogens encoding specific
proteases, such as hepatitis C virus, cytomegalovirus and malaria.
Abstract 4423: Novel therapeutic potential in targeting the microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma
Authors: Qian Zhou, Arthur K-K Ching, Wilson K-C Leung, Carol Szeto, Shuk-Mei Ho, Chris C. Holmes, Yun-fei Yuan, Paul B-S Lai, Winnie Yeo, Nathalie Wong
Journal: Cancer Research (2010)

Abstract Hepatocellular carcinoma (HCC) shows low responses to most conventional chemotherapies. To facilitate target identifications for novel therapeutic developments, we deployed gene expression profiling on 43 paired HCC tumors and adjacent non-tumoral liver. Coupled with ontology analysis, the major functional process suggested in the malignant transformation of HCC was microtubule-related cellular assembly. We further examined the potential use of microtubule targeting Taxane drugs, including Paclitaxel and Docetaxel, and compared findings to the results obtained from Doxorubicin, a common chemotherapeutic agent used in the treatment of a number of neoplasms. Recent studies showed that drug delivery by nanoparticles have enhanced efficacy with reduced side effects. In this regard, the nanoparticle albumin-bound (nab)-Paclitaxel was also examined. In a panel of HCC cell lines studied, a high sensitivity towards Taxane drugs was generally found, although the effect from nab-Paclitaxel was most profound. The nab-Paclitaxel showed an effective IC50 dose at 15-fold lower than Paclitaxel alone or the derivative analogue Docetaxel, and approx.450-fold less compared to Doxorubicin. Flow cytometric analysis confirmed a cell cycle blockade at the G2/M phase and increased apoptosis following treatment with nab-Paclitaxel. In-vivo animal study also showed that nab-Paclitaxel readily inhibited xenograft growth with less toxicity compared to other anti-microtubule drugs and Doxorubicin. Silencing of a major microtubule regulatory gene STMN1 suggested a distinct synergistic effect in the combined treatment with nab-Paclitaxel. Our findings in this study would suggest the microtubule organizations to represent a promising target for treatment developments in HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4423.