tbuckley/cabot-search huggingface dataset:
Potential False-Positive Bone Scan Secondary to a Calcified Venous Thrombus
Authors: LAWRENCE C. SWAYNE, JAMES COLLINS, FRED M. PALACE, JOHN J. CASTRONUOVO
Journal: Clinical Nuclear Medicine (1993)

The authors report a rare case of uptake in a calcified venous thrombus on bone scintigraphy that simulated a pelvic fracture in a patient with a history of trauma. The absence of any findings on the posterior image suggested that the abnormal focus was located in the anterior pelvic soft tissues. A CT scan revealed a calcified venous thrombus overlying the left acetabulum, and a venous doppler study confirmed the presence of a thrombus in the left femoral vein.
HIV-Related Herpes Simplex Virus Infection
Authors: Kim Eagle, Andrew Samel, Howard Heller
Journal: New England Journal of Medicine (1992)

The two ulcerations visible on the scalp of a 41-year-old man with human immunodeficiency virus (HIV) infection had become progressively larger over a two-month period. Herpes simplex virus was cultured from a biopsy specimen, and multinucleated giant cells were seen on histopathological analysis. The lesions resolved after treatment with acyclovir.
Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion
Authors: Carlos A. Valverde, Dmytro Kornyeyev, Marcela Ferreiro, Azadé D. Petrosky, Alicia Mattiazzi, Ariel L. Escobar
Journal: Cardiovascular Research (2009)

AimsMyocardial stunning is a contractile dysfunction that occurs after a brief ischaemic insult. Substantial evidence supports that this dysfunction is triggered by Ca2+ overload during reperfusion. The aim of the present manuscript is to define the origin of this Ca2+ increase in the intact heart.
Is discussing futile treatments really best for dying patients?
Authors: M. McCartney
Journal: BMJ (2014)

When US doctors were asked if they would want cardiopulmonary resuscitation (CPR) in the case of major cerebral injury, 90% of them said no thank you.1 CPR, as with all treatments, has limitations and side effects, causing bodily injury and, in terminal illness, a medicalised death. It changes our last minutes from what could be a peaceful process into a medical battleground. And it’s been found to be “futile” in patients receiving palliative care for cancer.2

So it’s a concern that the Court of Appeal has found that doctors breached a British patient’s right to a private life when they added a “Do not attempt cardiopulmonary resuscitation” (DNACPR) order to her notes without her knowledge.3 4

Janet Tracey had terminal …
Antiplatelet Therapy to Prevent Cardiovascular Events and Mortality in Patients With Intermittent Claudication
Authors: Peng Foo Wong, Lee-Yee Chong, Gerard Stansby
Journal: JAMA (2013)

Do antiplatelet therapies reduce risk of all-cause mortality, cardiovascular disease (CVD) mortality, and cardiovascular events in patients with intermittent claudication? Which antiplatelet is most strongly associated with a reduced risk of all-cause and CVD mortality?In patients with intermittent claudication, antiplatelet therapies are associated with lower all-cause and CVD mortality compared with placebo. Compared with all antiplatelet therapies, the strongest evidence exists for thienopyridines, such as clopidogrel.
Vascular Lesions of Cerebellum Associated With Lumbar Intradural Mass
Authors: Bruce J. Haskin
Journal: JAMA (1967)

Dr. Milton A. Weiner: A 22-year-old woman entered the hospital in 1964 with complaints of morning headaches, vomiting, and dizziness of several months' duration. There was a strong family history of Lindau-von Hippel disease involving numerous members of the family, including the patient's mother. At 17 years of age, she was found to have a hemangioma in the right eye which was treated by coagulation. Physical examination at the time of admission to the hospital in 1964 revealed papilledema, nystagmus, and some difficulty in coordination of her left hand. A cranial study and a left vertebral angiogram were obtained. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Hanelin, what is your opinion of these studies (Fig 1)? Dr. Joseph Hanelin: I would say this is a fairly typical hemangioblastoma. There is an area in the comparatively less-vascularized left cerebellar hemisphere which contains a highly vascularized nodule. This might be a cystic hemangioblastoma
[780] NOVEL HEPARANASE INHIBITOR PI-88 EXTENDS DISEASE FREE SURVIVAL IN A RANDOMIZED PHASE II ADJUVANT CLINICAL TRIAL IN PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC) AFTER CURATIVE RESECTION
Authors: P.J. Chen, PH. Lee, D.Y. Lin, C.C. Wu, L.B. Jeng, P.W. Lin, K.T. Mok, A.M. Gautam, J.R. Zalcberg
Journal: Journal of Hepatology (2007)
Value of an ACTH Test in Assessing Hypothalamic-Pituitary-Adrenocortical Function in Glucocorticoid-treated Patients
Authors: H. Kehlet, C. Binder
Journal: BMJ (1973)

Forty-eight patients receiving glucocorticoid treatment were tested with ACTH stimulation using alpha(1, 24) ACTH (tetracosactrin). All patients subsequently underwent non-acute major surgery without any glucocorticoid administration, and their clinical course and plasma corticosteroids were followed closely. No case of adrenocortical insufficiency was observed. A highly significant correlation was found between the pre-operative adrenocortical response to ACTH and the hypothalmic-pituitary-adrenocortical (H.P.A.) response to surgery. A normal response to ACTH stimulation was never followed by a greatly impaired H.P.A. response to surgery. It seems that a simple ACTH stimulation test is reliable in predicting the integrated H.P.A. response to major stress in glucocorticoid-treated patients.
p38 MAP Kinase Mediates Inflammatory Cytokine Induction in Cardiomyocytes and Extracellular Matrix Remodeling in Heart
Authors: Manxiang Li, Dimitrios Georgakopoulos, Gang Lu, Lisa Hester, David A. Kass, Jeffery Hasday, Yibin Wang
Journal: Circulation (2005)

Increasing evidence suggests that development of heart failure involves activation of stress-response inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6. Yet, the myocyte contribution to their induction in failing hearts and the underlying regulatory mechanism in stressed myocardium remain unclear.In cultured cardiac myocytes, specific activation of stress-activated mitogen-activated protein kinase, p38, by upstream activator MKK6bE led to significant induction of tumor necrosis factor-alpha and interleukin-6 secretion, whereas treating cells with a selective p38 inhibitor (SB239068) significantly blocked the cytokine secretion from myocytes and increased their intracellular accumulation. Targeted expression of MKK6bE in transgenic hearts also resulted in a marked elevation in plasma tumor necrosis factor-alpha and interleukin-6; oral administration of SB239068 resulted in a significant reduction in their plasma levels but an increase in intracardiac accumulation of both cytokines. MKK6bE transgenic hearts developed marked interstitial fibrosis with increased matrix metalloproteinase abundance and selective induction of tissue inhibitor of matrix metalloproteinase-1; this extracellular matrix remodeling was also significantly attenuated by p38 inhibition. Along with cytokine induction and extracellular remodeling, MKK6bE transgenic animals displayed impaired hemodynamic function, whereas p38 inhibition improved the cardiac performance and prolonged the survival of the animals.Stress-activated p38 kinase is a critical regulator of inflammatory response in cardiomyocytes with significant contribution to pathological remodeling in stressed myocardium. Inhibition of p38 may represent a useful therapeutic avenue to ameliorate cardiac pathology and heart failure evolution.
The Role of 99mTc-Bound Phosphates and Grey Scale Echography in the Differentiation of Pelvic Tumors
Authors: ORLANDO L. MANFREDI, JOHN E. ARUNY
Journal: Clinical Nuclear Medicine (1979)

99mTc-pyrophosphate and 99mTc-diphosphonate have successfully been employed in the diagnosis of neoplastic pelvic disease in women. In our ongoing study, 48 women with pelvic masses, underwent dynamic pelvic scintigraphy, correlative ultrasonography and exploratory laparotomy. Dynamic scintigraphy and region of interest time/activity curves generated from computerized data acquisition have proven effective in the differential diagnosis of uterine leiomyomas from ovarian cysts. In a group of 24 women whose scintigraphic data were consistent with our criteria for uterine leiomyoma, 21 were confirmed histologically. Of 30 women, 29 were accurately diagnosed on scintigraphy as having an ovarian cyst and two patients with coexisting ovarian cysts and uterine fibroids were both correctly diagnosed prior to surgery. Detected lesions ranged from 6--22 cm in diameter. Our findings support the use of dynamic pelvic scintigraphy for differentiating uterine leiomyomas from ovarian cysts.
Anti-HCV antibodies in patients with NANB chronic hepatitis treated with recombinant alpha interferon (r α IFN)
Authors: A. Aiello, M.A. Frenl, A. Spadaro, I. Calaoristi, A. Fava, M.L. Resta, G. Berlinghieri, G.F. Mauro, O. Ferrau
Journal: Journal of Hepatology (1990)
Glioma Grade Is Associated with the Accumulation and Activity of Cells Bearing M2 Monocyte Markers
Authors: Michael Prosniak, Larry A. Harshyne, David W. Andrews, Lawrence C. Kenyon, Kamila Bedelbaeva, Tatiyana V. Apanasovich, Ellen Heber-Katz, Mark T. Curtis, Paolo Cotzia, D. Craig Hooper
Journal: Clinical Cancer Research (2013)

Abstract Purpose: This study is directed at identifying the cell source(s) of immunomodulatory cytokines in high-grade gliomas and establishing whether the analysis of associated markers has implications for tumor grading. Experimental Design: Glioma specimens classified as WHO grade II–IV by histopathology were assessed by gene expression analysis and immunohistochemistry to identify the cells producing interleukin (IL)-10, which was confirmed by flow cytometry and factor secretion in culture. Finally, principal component analysis (PCA) and mixture discriminant analysis (MDA) were used to investigate associations between expressed genes and glioma grade. Results: The principle source of glioma-associated IL-10 is a cell type that bears phenotype markers consistent with M2 monocytes but does not express all M2-associated genes. Measures of expression of the M2 cell markers CD14, CD68, CD163, and CD204, which are elevated in high-grade gliomas, and the neutrophil/myeloid-derived suppressor cell (MDSC) subset marker CD15, which is reduced, provide the best index of glioma grade. Conclusions: Grade II and IV astrocytomas can be clearly differentiated on the basis of the expression of certain M2 markers in tumor tissues, whereas grade III astrocytomas exhibit a range of expression between the lower and higher grade specimens. The content of CD163+ cells distinguishes grade III astrocytoma subsets with different prognosis. Clin Cancer Res; 19(14); 3776–86. ©2013 AACR.
Pulmonary function abnormalities in thalassemia major and the role of iron overload.
Authors: J M Factor, S R Pottipati, I Rappoport, I K Rosner, M L Lesser, P J Giardina
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

To determine the predominant abnormality of pulmonary function in patients with thalassemia major (TM), we evaluated 29 patients with TM who were receiving hypertransfusion therapy and chelation with desferrioxamine (DFO), and who ranged in age from 6 to 40 yr (mean 19.8 +/- 8.5 yr). A reduction in the total lung capacity (TLC) was the most striking abnormality, found in 21 of 29 patients (79%). Fourteen of these patients (67%) had a moderate or severe reduction in TLC. Expiratory flow rates, FEV1, and FEF25-75 were decreased below predicted values in 48 and 17% of the patients, respectively, but no patients had pure obstructive disease. Significant hypoxemia (oxygen saturation of less than 95%) was observed in only one patient. There was a significant inverse correlation between TLC and patient age (p < 0.003), transfusional iron burden (p < 0.003) and DFO ratio (p < 0.024). Restrictive disease is the predominant abnormality of pulmonary function in TM, with a mixed restrictive-obstructive pattern in a small number of patients. The restrictive disease becomes more severe with increasing age, and the degree and duration of iron overload appear to be important in its pathogenesis. The role of DFO therapy in preventing the pulmonary complications associated with TM requires further study.
Responsibilities of the Primary Care Internist in the Care of the Allergic Patient
Authors: Roy Patterson, Jordan N. Fink
Journal: Annals of Internal Medicine (1985)

Editorials1 February 1985Responsibilities of the Primary Care Internist in the Care of the Allergic PatientROY PATTERSON, M.D., JORDAN N. FINK, M.D.ROY PATTERSON, M.D.Search for more papers by this author, JORDAN N. FINK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-2-263 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe incidence of various allergic diseases depends on the method of classification used in epidemiologic studies but involves a significant percentage of the population (1). This high-incidence disease is frequently associated with mild intermittent or chronic symptoms. However, allergic disease can be fatal, although the incidence of fatalities is low and most are avoidable. Between these extremes are patients with differing degrees of severity of disease ranging from moderate discomfort to an inability to lead a normal life, an inability to work, and to incapacitation. Most allergic patients can live comfortably if appropriate allergic management with modern pharmacotherapy or immunotherapy...References1. . Asthma and the Other Allergic Diseases: NIAID Task Force Report. Bethesda, Maryland: U.S. Public Health Service, 1979; NIH publication no. 79-387. Google Scholar2. SALVAGGIO J, ed. Primer on allergic and immunologic diseases. JAMA. 1982;248:2579-772. CrossrefMedlineGoogle Scholar3. RICKETTIGREENBERGERMINTZERPATTERSON APRR. Allergic bronchopulmonary aspergillosis. Arch Intern Med. 1983;143:1553-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical College of Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInternal Medicine and Training in AllergyDAVID M. LANG, M.D.Referrals to AllergistsRICHARD GROSS, M.D. 1 February 1985Volume 102, Issue 2Page: 263-264KeywordsAllergic diseasesAllergy immunotherapyDrug therapyEpidemiology Issue Published: 1 February 1985 PDF DownloadLoading ...
Cancer research provides a good economic return as well as health gains, report says
Authors: N. Hawkes
Journal: BMJ (2014)

Cancer research brings economic as well as health benefits and is a sound investment of public money, a new analysis has claimed.1

Every pound (€1.25; $1.70) invested in cancer research generated an annual return of 40p a year thereafter, the study concluded—easily exceeding the returns demanded by the Treasury. Jonathan Grant of King’s College London, who led the study, said, “This return includes health benefits equivalent to around 10p plus a further 30p which is the best estimate of the ‘spillover’ effect from research to the wider economy. 

“An internal rate of return of 40p easily meets the UK government’s minimum threshold of 3.5p per pound for investments, …
THE TREATMENT OF ULCERATIVE MOUTH LESIONS WITH ORABASE.
Authors: R. J. RUSHTON
Journal: British Journal of Dermatology (1962)

Journal Article THE TREATMENT OF ULCERATIVE MOUTH LESIONS WITH ORABASE. Get access R. J. RUSHTON, M.B., B.Chir. R. J. RUSHTON, M.B., B.Chir. Late Registrar, Rupert Hallam Department of Dermatology, Royal Infirmary, Sheffield Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 74, Issue 12, 1 December 1962, Pages 462–463, https://doi.org/10.1111/j.1365-2133.1962.tb13447.x Published: 01 December 1962
Health “Reform”: Massacre on Capitol Hill
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1978)

Sifting through the legislative debris left behind when the 95th Congress adjourned last month, it is possible to conclude that the remaking of the American health-care system — perhaps the most ambitious and earnestly sought-after domestic objective of the Carter Administration — has been battered to oblivion on Capitol Hill.Looking down the casualty list, we find that though a weakened, vote-catching hospital cost-containment bill did slip through the Senate in the final, hectic days of the session, 47–42, an assortment of interests quickly rallied to prevent it from even coming to the floor of the House. Hospital lobbyists, backed . . .
Stronger Laws and Stiffer Penalties Aimed at Keeping Drivers Safely Sober
Authors: Timothy F. Kirn
Journal: JAMA (1988)

IN 1983, a Gallup poll suggested that 80% of Americans would not hesitate to get behind the wheel after drinking. Four years later, according to the National Commission Against Drunk Driving, 77% say they avoid driving after imbibing. The commission, located in Washington, DC, claims that change in response represents a major shift in America's attitude. These days, music star Stevie Wonder can record "Don't Drive Drunk," legions of other entertainers brag publicly about "giving it up," and Foster Brooks, the comedian who made a career of playing inebriates, would simply not be funny. Attitudes about alcohol have been changing rapidly, and with regard to drunken driving especially. The reason: the Department of Transportation (Wash, DC) estimates that two of every five Americans will be involved in an alcohol-related crash in their lifetime. During the past five years, 500 drunken driving laws have been newly enacted or existing laws strengthened.
Optical Transmembrane Potential Measurements During Defibrillation-Strength Shocks in Perfused Rabbit Hearts
Authors: Xiaohong Zhou, Raymond E. Ideker, Timothy F. Blitchington, William M. Smith, Stephen B. Knisley
Journal: Circulation Research (1995)

Abstract To study the optical transmembrane potential change (ΔF) induced during shocks, optical recordings were obtained in 15 isolated perfused rabbit hearts treated with the potentiometric dye di-4-ANEPPS and diacetyl monoxime. Shock electrodes were sutured on the right and left ventricles. A laser beam 30 μm in diameter was used to optically excite di-4-ANEPPS. Fluorescence from a region 150 μm in diameter was recorded during a shock. In the macroscopic study (six animals), there were nine recording spots that were 3 mm apart between the two shock electrodes. In the microscopic study, there were three recording regions that were 3 mm away from either shock electrode and midway between them, with nine recording spots that were 30 μm (three animals), 100 μm (three animals), and 300 μm (three animals) apart in each region. After 20 S 1 stimuli, a 10-ms truncated exponential S 2 shock of defibrillation-threshold strength was given during the plateau of the last S 1 action potential. In the microscopic study, shocks were also given during diastole, with ΔF recordings at the three recording regions. Shocks of both polarities were tested. ΔF during the shock was expressed as a percentage of the fluorescence change during the S 1 upstroke action potential amplitude (the S 1 F apa ), ie, ΔF/F apa %. In the macroscopic study, the magnitudes of ΔF/F apa % from recording spots 1 to 9, numbered from the left to the right ventricular electrodes, were 77±41%, 46±32%, 32±27%, 28±20%, 37±25%, 24±20%, 33±22%, 37±25%, and 59±29%, respectively ( P &lt;.05 among the nine spots). Depolarization or hyperpolarization could occur near either shock electrode with both shock polarities, but the magnitude of hyperpolarization was 1.8±0.9 times that of depolarization at the same recording spot when the shock polarity was reversed ( P &lt;.01). In the microscopic study, the change in ΔF/F apa % varied significantly over the microscopic regions examined. The maximum values of ΔF/F apa % for hyperpolarizing shocks during diastole reached only 7±10% of those for shocks during the plateau ( P &lt;.01). During diastole, the time until a new action potential occurred after the beginning of the shock was shorter when the membrane was depolarized (1.1±0.5 ms) than when it was hyperpolarized (12.8±9.1 ms, P &lt;.01). Conclusions are as follows: (1) A shock can induce either hyperpolarization or depolarization. (2) Hyperpolarization or depolarization during a shock can occur near either the anodal or cathodal shock electrode. (3) Variation of ΔF/F apa % exists within a microscopic region. (4) The effects of a shock during an action potential plateau are different from those during diastole. (5) The different responses of the ΔF during a shock affect the excitation latency during diastole.
Ventricular Septal Defect in Infants and Children
Authors: DONALD C. FYLER, ABRAHAM M. RUDOLPH, MARTIN H. WITTENBORG, ALEXANDER S. NADAS
Journal: Circulation (1958)

Now that ventricular septal defect is amenable to surgical repair it is most important to define the indications for surgical intervention. In this paper the natural history of the disease and its clinical and physiologic characteristics are carefully detailed. These observations permit better recognition and understanding of the condition and offer a basis for comparison with results after surgery.
Childhood Sarcoidosis — A Study of 18 Patients
Authors: Louis E. Siltzbach, Gerald M. Greenberg
Journal: New England Journal of Medicine (1968)

Of 18 children with a tissue diagnosis of sarcoidosis 11 were symptomatic; seven were asymptomatic, but on routine x-ray study exhibited hilar adenopathy often combined with pulmonary mottling. The children with symptoms were younger, had more extensive disease and a longer and more complicated course of illness than those who were asymptomatic; they frequently required glucocorticosteroids or chloroquine. The asymptomatic children fared better than those with symptoms. Asymptomatic sarcoidosis in children is more frequent than is currently recognized but its true prevalence is likely to remain unknown, since mass chest x-ray surveys and routine chest radiography are not systematically pursued in tuberculin-negative children. Earlier recognition of sarcoidosis in children may prevent some of the complications of this disorder such as blindness and pulmonary insufficiency.
Comments Regarding the Controversy of the "National" Origin of the University in Prague
Authors: Kornel L. Terplan
Journal: JAMA (1966)

A short while back, a few letters were sent to the editor ofThe Journal(see also p 190 in this issue) regarding the University of Prague, which was founded by Charles IV in the year 1348. Some of these letters imply that the Charles University was from its very beginning a national Czech institution founded by the King of Bohemia, while others claim that Charles was at the same time a Roman king and emperor of the Holy Roman Empire and actually founded the university in his dual capacity as king of Bohemia and king of the Roman Empire. To the writer it appears somewhat unrealistic to try to interpret this historic event which took place more than 600 years ago in the latter half of the Middle Ages in terms of the modern connotation of the word "nationality." It was in one of the first gatherings of the
Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm
Authors: Luís F.C. Menezes, Yiqiang Cai, Yasuyuki Nagasawa, Ana M.G. Silva, Mary L. Watkins, Aline M. Da Silva, Stefan Somlo, Lisa M. Guay-Woodford, Gregory G. Germino, Luiz F. Onuchic
Journal: Kidney International (2004)