tbuckley/cabot-search huggingface dataset:
Abstract 2353: Therapeutic effect of cilengitide in combination with CKD-602, a campothecin derivative, against experimental glioblastoma
Authors: Young-Hoon Kim, Judy Park, Jin Kyung Lee, Bokyong Kim, Seung Ah Choi, Ji Hoon Phi, Chul-Kee Park, Seung-Ki Kim, Chae-Yong Kim
Journal: Cancer Research (2012)

Abstract The prognosis and the clinical course for glioblastoma patients remain dismal in spite of various multidisciplinary approaches of treatment, such as concurrent chemoradiotherapy with temozolomide. Especially, the resistance to temozolomide of primary or recurrent glioblastoma is the significant obstacle to the cure of this tumor. In the present study, we evaluated the in vitro and in vivo antitumor effect of cilengitide in combination with CKD-602, a camptothecin derivate, for experimental glioblastoma. The combination treatment with cilengitide and CKD-602 enhanced the cytotoxic effects to the glioblastoma cell lines, including U87MG and U251MG and increased the proportion of apoptosis of the tumor cells, compared with the monotherapy with either drug. Nude mice with established U87MG glioblastoma were assigned to the 4 groups; control group (injection with saline only), 2 cilengitide group (injection with a dose of cilengitide at 2 mg/mL), CKD-602 group (injection with a dose of CKD-602 at 2 mg/mL), and combination group. In animals with combination therapy, the significant reduction of tumor volume was demonstrated (p &amp;lt; 0.05). The immunohistochemistry with CD31 and Annexin-V showed that this synergistic effect was caused by the decrease of angiogenesis by cilengitide and the increase of apoptosis by CKD-602. Cilengitide in combination with CKD-602 could be an alternative treatment option for glioblastoma. Keywords; glioblastoma; cilengitide; CKD-602; angiogenesis; apoptosis Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2353. doi:1538-7445.AM2012-2353
Early Predictors of In-Hospital Death in Infective Endocarditis
Authors: Vivian H. Chu, Christopher H. Cabell, Daniel K. Benjamin, Erin F. Kuniholm, Vance G. Fowler, John Engemann, Daniel J. Sexton, G. Ralph Corey, Andrew Wang
Journal: Circulation (2004)

Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE.Two hundred sixty-seven consecutive patients with definite or possible IE by modified Duke criteria and echocardiography performed within 7 days of presentation were evaluated. Acute physiology was assessed by the Acute Physiology, Age, Chronic Health Evaluation II (APACHE II) score at the time of presentation, and early heart failure was diagnosed by Framingham criteria. In-hospital mortality rate in the cohort was 19% and similar for patients with definite or possible IE (20% versus 16%, respectively; P=0.464). Independent predictors of death determined by logistic regression modeling were diabetes mellitus (OR 2.48; 95% CI, 1.24 to 4.96), Staphylococcus aureus as causative organism (OR, 2.06; 95% CI, 1.01 to 4.20), APACHE II score (OR, 1.07; 95% CI, 1.01 to 1.12), and embolic event (OR, 2.79; 95% CI, 1.15 to 6.80). Early echocardiographic findings of the Duke criteria were not predictive of death.Early in the course of IE, readily available clinical characteristics that reflect the host-pathogen interaction are predictive of in-hospital death. These factors may identify those patients with IE for more aggressive treatment.
Depot Phenothiazine Treatment in Acute Psychosis: A Sequential Comparative Clinical Study
Authors: CHING-PIAO CHIEN, JONATHAN O. COLE
Journal: American Journal of Psychiatry (1973)

In a study of the relative efficacy of three drug treatments for 46 newly hospitalized acutely psychotic patients, fluphenazine enanthate, alone or in combination with chlorpromazine, proved significantly more effective than chlorpromazine alone. Although fluphenazine enanthate, alone or in combination, produced more extrapyramidal side effects than chlorpromazine alone despite prophylactic antiparkinsonian medication, additional antiparkinsonian medication adequately controlled these side effects.
5-Lipoxygenase–Activating Protein
Authors: Magnus Bäck, Ariane Sultan, Olga Ovchinnikova, Göran K. Hansson
Journal: Circulation Research (2007)

Transforming growth factor-β (TGF-β) is a major antiinflammatory mediator in atherosclerosis. Transgenic ApoE −/− mice with a dominant-negative TGFβ type II receptor (dnTGFβRII) on CD4 + and CD8 + T cells display aggravated atherosclerosis. The aim of the present study was to elucidate the mechanisms involved in this enhanced inflammatory response. Gene array analyses identified the 5-lipoxygenase–activating protein (FLAP) among the most upregulated genes in both the aorta and adipose tissue of dnTGFβRII transgenic ApoE −/− mice compared with their ApoE −/− littermates, a finding that was confirmed by real-time quantitative RT-PCR. Aortas from the former mice in addition produced increased amounts of the lipoxygenase product leukotriene B 4 after ex vivo stimulation. FLAP protein expression in both the aorta and adipose tissue was detected in macrophages, but not in T cells. Four weeks of treatment with the FLAP inhibitor MK-886 (10 mg/kg in 1% tylose delivered by osmotic pumps) significantly reduced atherosclerotic lesion size and T-cell content. Finally, FLAP mRNA levels were upregulated approximately 8-fold in adipose tissue derived from obese ob/ob mice. In conclusion, the results of the present study suggest a key role for mediators of the 5-lipoxygenase pathway in inflammatory reactions of atherosclerosis and metabolic disease.
Reviews and Notes: HIV Infection: A Clinical Manual
Authors: Timothy W. Lane
Journal: Annals of Internal Medicine (1994)

Literature of Medicine15 May 1994Reviews and Notes: HIV Infection: A Clinical ManualTimothy W. LaneTimothy W. LaneMoses H. Cone Memorial Hospital, Greensboro, NC 27401.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-10-199405150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail HIV Infection: A Clinical ManualSecond edition. Howard Libman and Robert A. Witzburg; eds. 555 pages. Boston: Little, Brown; 1993. $32.50.Those who care for patients with human immunodeficiency virus (HIV) infection, teach others about it, and perform clinical research as I do have amassed various local educational materials such as printed guides and manuals. The intended audience is usually medical students and resident physicians, with good reason because they provide an increasingly disproportionate amount of care to HIV-infected persons in this country. Several academic centers have taken their local educational manuals “public” in the past few years, and as ... Author, Article, and Disclosure InformationAffiliations: Moses H. Cone Memorial Hospital, Greensboro, NC 27401. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1994Volume 120, Issue 10Page: 895-896KeywordsAIDSHIVHIV infectionsInpatientsLibrariesNutritionOutpatientsPatientsSequence analysisSyphilis ePublished: 15 August 2000 Issue Published: 15 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Removal of Impacted Endoscopic Basket and Stone from the Common Bile Duct by Extracorporeal Shock Waves
Authors: M. Merrett, P. Desmond
Journal: Endoscopy (1990)

See also: Complications of Endoscopic Sphincterotomy and their TreatmentEndoscopy 1981; 13(05): 197-199DOI: 10.1055/s-2007-1021682
Prevention of Cardiac Necrosis by Amiloride
Authors: Hans Selye
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neutrophil vacuolation in acetaminophen‐induced acute liver failure
Authors: Godhev K Manakkat Vijay, Victoria T Kronsten, Barbara J. Bain, Debbie L Shawcross
Journal: American Journal of Hematology (2015)

An 18-year-old female was admitted to the liver intensive care unit with hyperacute liver failure in February 2012, 4 days after taking a staggered overdose of 15 g of acetaminophen. The patient had initially presented to her local hospital 24 hr earlier with abdominal pain and blood tests had then revealed an acetaminophen level of 65 mg/l, alanine aminotransferase 6228 iu/l, aspartate aminotransferase 5600 iu/l, bilirubin 51 µmol/l, International Normalised Ratio 3.3, lactate 4.4 mmol/l, and creatinine 48 µmol/l. She had no past medical history of note, took no regular medications and did not drink alcohol. She developed grade 3 hepatic encephalopathy within the first hour of admission with cardiovascular collapse, metabolic acidosis, and renal failure. Her full blood count showed leucocytes 15.6 × 109/l, neutrophils 13.9 × 109/l, hemoglobin concentration 137 g/l, and platelets 209 × 109/l. Clinically, there was no evidence of infection, C-reactive protein was <2 mg/l, and blood and urine cultures were negative. Plasma interleukin (IL)-6, IL-8, and granulocyte colony-stimulating factor (G-CSF) were markedly increased. A blood film revealed neutrophils with marked toxic granulation and prominent vacuolation (left panel and bottom right); vacuolation was also apparent on electron microscopy (top right). The patient was commenced on an acute liver failure management pathway and was listed for emergency liver transplantation. She underwent a right lobe auxillary liver transplant 5 days after her initial presentation. Neutrophil vacuolation is usually indicative of bacterial infection and is otherwise uncommon. We have observed it in patients with acute liver failure who are free of infection. We postulate that it is the result of increased levels of G-CSF.
Lipoprotein Electrophoretic Patterns, Serum Lipids, and Coronary Heart Disease
Authors: J. R. Masarei, M. Summers, D. H. Curnow, K. J. Cullen, M. G. McCall, N. S. Stenhouse, T. A. Welborn
Journal: BMJ (1971)

Lipoprotein electrophoresis was performed on serum from subjects with and without coronary heart disease, and the patterns compared with the serum concentrations of triglyceride and cholesterol. The beta- and pre-beta-lipoproteins, expressed as a percentage of the total lipoprotein, correlate strongly with the cholesterol and triglyceride concentrations, respectively. The beta- and pre-beta-lipoprotein concentrations are even more strongly correlated with these lipid measurements. The lipoprotein pattern does not have greater discriminant value for coronary heart disease than does the triglyceride or cholesterol concentration. There would seem to be little justification for the use of lipoprotein electrophoresis in screening the general population for coronary heart disease.
Christian Medical Fellowship
Authors: J. Cassidy
Journal: BMJ (2011)

The Christian Medical Fellowship was formed in 1949, its mission to unite and equip Christian healthcare professionals. Its members include more than 4000 doctors and around 1000 medical students in the United Kingdom.

Abortion, palliative care, and new technologies in medicine are all important topics for the fellowship. Members regularly engage in media debate to promote pro-life and anti-euthanasia arguments.

But it is the question of how Christian doctors share their faith with patients that is currently causing the most controversy. A fellowship member, Richard Scott, is challenging a formal warning from the General Medical Council for speaking about religion to a patient. He is taking his case to a full hearing, supported by the Christian Legal Centre.

The Kent general practitioner was sent a warning letter by the …
Computerized tabulation of cine coronary angiograms. Its implication for results of randomized trials.
Authors: R G Favaloro
Journal: Circulation (1990)

The quality of cine angiography is excellent in our days, and as a consequence some of the pitfalls encountered in previous randomized trials are not currently present. An example can be found in the CASS analysis of the reproducibility of coronary arteriographic reading by the Quality Control Committee Sessions: "There is an indication that different clinics" involved in the CASS trial "can reduce the variability between their readings by concerted effort to improve both the quality and the completeness of the angiographic examination." The introduction of electronic calipers to judge the severity of the obstruction can eliminate human errors. The computerized protocol has the disadvantage that it takes longer to tabulate cine coronary angiography and it will depend on its pattern, but it certainly will not be as long as filling in the CASS protocol. However, this effort is justified because it will enrich our knowledge of coronary arteriosclerosis. As a result, patients will be divided into proximal (1, 2, 12, 13, and 19), middle (mainly, 3, 14, and 20), and distal (remainder) segments. Sometimes midsegments can be important. For example, in the report from CASS related to the left main equivalent lesions, the 5-year survival rate was 48% if the obstruction on the left anterior descending was proximal and increased to 71% if it was more distal. Several randomized studies to compare PTCA with CABG as suggested by Gruentzig et al in 1979 are underway, and it is hoped that the data will be properly analyzed. However, if cine coronary angiography and the status of the left ventricle are not carefully tabulated (classification of patients into left main trunk or one-, two-, or three-vessel disease is not sufficient), the results of the randomized trials comparing PTCA with CABG will add more confusion instead of clarifying proper therapeutic implications.
Abstract 4844: Genomics aberrations and BRCA1 silencing in hereditary triple negative breast tumors in Chilean women
Authors: Teresa Tapia, Alejandro Sanchez, Carolina Alvarez, Valeria Cornejo, Wanda Fernandez, Manuel Alvarez, Mauricio Camus, Pilar Carvallo
Journal: Cancer Research (2011)

Abstract Breast cancer is one of the most common cancers in women worldwide and the second cause of death by cancer among women in Chile. Either sporadic or hereditary breast cancers show a wide variety of tumor phenotypes, leading to individual clinic responses to specific treatments. Among breast cancer tumors, a group named as triple negative breast cancer (TNBC) does not express hormone receptors and HER2 (ER-, PR-, HER2-). For these tumors no specific treatment complementing chemotherapy has been developed yet. Therefore the study of the genes involved in the progression of TNBC tumor may provide a rationale for the future exploration of therapeutic strategies. TNBC is frequently observed in women carrying a germline mutation in the BRCA1 gene and in approximately 30% of non-carrier women with loss of expression of BRCA1 protein. Our aim, is to identify common genomic aberrations among TNBC tumors and to evaluate BRCA1 silencing by hypermethylation of its promoter in TNBC tumors. It has been described that about 80-90% of TNBC tumors belong to the basal-like molecular subtype, constituting a biological and clinical distinct subgroup. To determine the basal-like subtype we evaluated the expression of Cytokeratin 14 (CK14) marker in 22 hereditary TNBC. Our results revealed that a 63% (14/22) of the tumors express CK14, suggesting that these tumors belong to the basal-like subtype. Additionally, we analyzed the methylation status of the BRCA1 promoter and its correspondent protein expression in the tumors. A 77% (17/22) of the tumors had BRCA1 promoter hypermethylation. Of all tumors 32% (7/22) had absent or reduced nuclear expression of BRCA1. Interestingly, we found 54% (12/22) of the TNBC tumors with a cytoplasmic expression of BRCA1. Finally, we also analyzed through array-CGH, 19 hereditary TNBC tumors to identify common genomic aberrations between these tumors. The array-CGH analysis revealed the gain of the genomic regions 7q34, 15q26.1 and 16p13.3 and the deletion of the regions 1q21.1, 9q33.3, 18q22.1-q22.3 and 19q13.41 in more than 30% of the TNBC tumors. In conclusion, we found that 71% of tumors expressing CK14 have absent or reduced expression of the BRCA1. On the other hand, 61% of tumors with promoter hypermethylation of BRCA1 have loss expression of its protein. Interestingly, the region deleted 1q21.1 was found in 94% of the hereditary TNBC tumors. Financed by FONDECYT 1080595 and CONICYT 24091058. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4844. doi:10.1158/1538-7445.AM2011-4844
Clinical Lecture concerning Lead-Poisoning and its Treatment
Authors: A. Fleming
Journal: BMJ (1865)

GENTLEMEN,-The cases to which I propose to direct your attention to-day belong to a class that, in this large and busy manufacturing town, is often under our care.We see here, in hospital practice, examples of chronic lead-poison- ing of every degree of severity, from the simple colic which may be relieved in a day or two, to the deadly cachexia, with enfeebled brain and paralytic limb, which has carried some of our most skilled workmen to the grave, and has left many hopeless inmates of the workhouse.Glass-cutting and glass-polishing, the making of red lead, of brass taps, plumbing, the process of enamelling and of soldering iron, are among the occupations which in Birmingham furnish cases of lead-poisoning.There are at present two factories of red lead in this town.In them, lead-poisoning was formerly frequent, and often severe; but of late years, in consequence of improved ventilation of the buildings and greater cleanliness of the workmen, the cases of poisoning are much rarer and milder.The painters and cutters in glass present the worst examples.This was the occupation of one of my patients in the Queen's Hospital, whose case I will now narrate to you.J. M., aged 36, by trade a glass-painter, was ad-
ACUTE LYMPHATIC LEUKEMIA AND INFECTIOUS MONONUCLEOSIS
Authors: Charles F. Ulrich
Journal: JAMA (1931)

It is our purpose at this time to report a fatal case of acute lymphatic leukemia, and another nonfatal case, in which a diagnosis of infectious mononucleosis was made. These cases are being reported for the purpose of comparison; hence a brief analysis of the clinical course, together with the morphology of the blood in both, should not be devoid of interest. The differential diagnosis should, ordinarily, not be difficult. However, confusion frequently occurs between acute leukemia and infectious mononucleosis. A correct diagnosis will usually be made if the patient is kept under observation for a period of time, and by repeated study of stained blood smears. The occurrence of acute leukemia with remissions renders a correct diagnosis extremely difficult. One not infrequently encounters atypical cases of idiopathic purpura, as well as agranulocytic angina, presenting blood pictures, clinical symptoms, and objective evidence that are strikingly similar, and leading one to
Adhesions in abdominal and pelvic surgery: benefit of laparoscopy over open surgery remains unproved
Authors: R. E. Andersson
Journal: BMJ (2013)

Ten Broek and colleagues’ review of postoperative adhesions did not include the largest study of postoperative small bowel obstruction after appendectomy (n=245 400), which had up to 30 years of follow-up.1 2 The methodology section provides no clues about why this study was not included. This raises questions about the completeness of the review. …
The Corner Drugstore
Authors: E. R. W. Fox
Journal: JAMA (1984)

The day of the "corner drugstore" is past. In some ways that's too bad. The drugstore was a pleasant place to visit. The graceful glass containers filled with red, green, and lavender liquid gave promise of the mysterious syrups and elixirs that were dispensed. As we entered yesterday's apothecary, our noses were greeted with indescribable aromas, medicinal and therefore curative. The friendly druggist, known to the townspeople as "Doc," was always ready to dispense pills, potions, and kindly advice. Old Doc had an air of mystery about him. He was able to decipher your physician's Latin scrawl, which he would study intently. Then he'd nod his head knowingly and retire to his inner sanctum to concoct the lifesaving medicament. If we chose to wait while the druggist worked his legerdemain, we would hear a scraping sound as pestle greeted mortar, or the gurgle of liquid as it was decanted into
Clinical Notes on a Case Lupus Treated in Berlin by Koch's Method
Authors: M. Morris, J. J. Pringle
Journal: BMJ (1891)

It may be considered a typical one both as regards the disease anld its progress under the treatment.T'lhe case is not advanced as one of cure, but the result ob- tained far exceeds that produced by any other known method at our disposal both in poinlt of efficacy and rapidity.At the s.ame time it belioves us to urge upon the profession the .necessityfor extreme caution in the use of this potent remeidy, especially as recent experience lhas demonstrated that the pheniomena followiing its use are iilconstant anid fre- quently alarmniing.E. N., aged 22, mechaniical engineer.inamily listory.-Mainpoinlts of importance: Is seventh of a aimiily of eight.Eldest sister is a complete invalid witl varies of hones of foot since the age of 12.One brotlher has manty disfigurinig scars oIn the nleck from suppuratiing glands, at the age of 10.Personal IHistor.-Mainpoinlts: After scarlatina, at tlle age of 5 years, lie had middle ear suppuration witlh discharge, and htas been quite deaf on that side ever since.From age of 6 to 13 years, lhad suppurative disease of bone of both ankles, (ic.atrices being nlow presenit.At age of 12 lhad severe suppuratiing glaid(is oIn ripjht side of neck, wlichl burst spontaine- ously, leavinig a disfiguriing scar.FK,ace: First spot of lupus on the riglt side of nose appeared in November, 1884, but was preceded by some affectioni of ni asal mucous mnembrane.Despite repeated cauterisation, d1isease spread rcapidIly anid destroyed a great portion of rioglt Ala of nose.Camne unider Mr. Morris's observatioii iin February, 1885, wlho lhas repeatedly scraped and cauterised it since; thle (lisease lhas thereby beeii arrested on thfe right sidc-, but s)reaad on ]eft.Palate: The palate was first involved ini thle summneir of 1885, the gums in the begininiiig of 1889.-Botli lhave beei firequently scrape(l aind cauterised.Wlands: Masses of caseous glanids lhave beeii reni)vNed from the neck oni five occasionsl siniee 1885.