Bronchiolitis Obliterans-Organizing Pneumonia Caused by Ticlopidine
Authors: Jose Luis Alonso-Martinez
Journal: Annals of Internal Medicine (1998)

Letters1 July 1998Bronchiolitis Obliterans-Organizing Pneumonia Caused by TiclopidineJose Luis Alonso-Martinez, MD, Jose Ignacio Elejalde-Guerra, PhD, and Degona Larrinaga-Linero, MDJose Luis Alonso-Martinez, MDHospital de Navarra; Pamplona, SpainSearch for more papers by this author, Jose Ignacio Elejalde-Guerra, PhDHospital de Navarra; Pamplona, SpainSearch for more papers by this author, and Degona Larrinaga-Linero, MDHospital de Navarra; Pamplona, SpainSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-1-199807010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ticlopidine, an inhibitor of platelet aggregation, is widely used to treat and prevent stroke and other thrombotic events and has been considered more effective than aspirin [1]. Side effects of ticlopidine include hematologic complications [2] and gastrointestinal and liver diseases [3]. We describe a patient who developed dyspnea, peripheral interstitial lung infiltrates, hypoxemia, and transbronchial biopsy alterations consistent with bronchiolitis obliterans-organizing pneumonia that resolved after withdrawal of ticlopidine therapy.A 76-year-old nonsmoking woman in whom giant-cell (temporal) arteritis was proven by biopsy and who had had a normal chest radiograph was receiving prednisone, 45 mg/d, and ticlopidine, ...References1. Hass WK, Easton JD, Adams HP Jr, Praise-Phillips W, Molony BA, Anderson S, et al. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. N Engl J Med. 1989; 321:501-7. Google Scholar2. Mataix R, Ojeda E, Perez MC, Jimenez S. Ticlopidine and severe aplastic anemia. Br J Haematol. 1992; 80:125-6. Google Scholar3. Grimm ES, Litynski JJ. Severe cholestasis associated with ticlopidine. Am J Gastroenterol. 1994; 89:279-80. Google Scholar4. Epler GR. Bronchiolitis obliterans organizing pneumonia: definition and clinical features. Chest. 1992; 102(1 Suppl):2s-6s. Google Scholar5. Bednar MM, Dooley RH, Tapanes R, Lublin JC, Gross CE. Ticlopidine augments chemiluminescence in human neutrophils. J Biolumin Chemilumin. 1995; 10:85-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hospital de Navarra; Pamplona, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClopidogrel-induced pneumoniaClopidogrel-Induced Interstitial Lung Disease: A Case ReportTiclopidineOrganizing pneumonia: Manifestation peculiarities, causes, and outcomesANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSTiclopidineTiclopidineDrug-induced bronchiolitis obliterans organizing pneumoniaTiclopidineIatrogenia a fármacos no contexto do Aparelho RespiratórioInterstitial Pneumonia Induced by Ticlopidine.Ticlopidine-Induced Interstitial Pulmonary DiseaseDrugs affecting blood coagulation, fibrinolysis, and hemostasisTiclopidine 1 July 1998Volume 129, Issue 1Page: 71-72KeywordsBiopsyBronchiolitisConnective tissue diseasesDyspneaLungsLymphocytesNeutrophilsPneumoniaTemporal arteritisThorax Issue Published: 1 July 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...