PROBABLE HEPATIC ALLERGY TO CHLORPROMAZINE AND DELIBERATE DESENSITIZATION
Authors: LEO WAITZKIN
Journal: Annals of Internal Medicine (1960)

Article1 July 1960PROBABLE HEPATIC ALLERGY TO CHLORPROMAZINE AND DELIBERATE DESENSITIZATIONLEO WAITZKIN, M.D.LEO WAITZKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-1-116 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report issues from studies concerning the pathogenesis of hepatic dysfunction due to chlorpromazine, the prophylactic and therapeutic influence thereon of synthetic adrenocortical hormones, and trials of deliberate desensitization.All of the patients studied had been hospitalized for neuropsychiatric illnesses, were in good physical health, and had no debilitating disease. Chlorpromazine was administered to them orally.The same battery of liver function tests was employed throughout the studies. It was composed of thymol turbidity, zinc turbidity, cephalin flocculation,abromsulfalein retention,bserum glutamic-oxalacetic transaminasecand usually serum glutamic-pyruvic transaminase,dserum alkaline phosphatase,etotal serum bilirubinfand prompt, direct-reacting bilirubin.gAfter the...Bibliography1. : Definition of words pertaining to allergy, J. Allergy 12: 202, 1941. CrossrefGoogle Scholar2. Waitzkin L: Hepatic dysfunction due to chlorpromazine hypersensitivity, Ann. Int. Med. 49: 607-619, 1958. LinkGoogle Scholar3. KeeneyWeissMohr ELHACF: The use of cortisone or ACTH during rapid desensitization of allergic patients, J. Allergy 26: 141-149, 1955. CrossrefMedlineGoogle Scholar4. Feldman PE: Clinical evaluation of Pacatal, Am. J. Psychiat. 114: 143, 1957. CrossrefMedlineGoogle Scholar5. MitchellSykesKing PHPA: Effect of "Pacatal" on symptoms in chronic psychotic patients, Brit. M. J. 1: 204-207, 1957. CrossrefMedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: Brockton, Massachusetts*Received for publication March 2, 1960.From the Medical Service, Veterans Administration Hospital, Brockton, Massachusetts.Requests for reprints should be addressed to Leo Waitzkin, M.D., Chief, Medical Service, Veterans Administration Hospital, Brockton, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMechanisms and prediction of drug-induced liver disease.Cholestatischer IkterusCLINICAL AND LABORATORY MANIFESTATIONS OF HEPATOTOXICITYPhenothiazine und Azaphenothiazine als HeilmittelProlonged Hepatic Dysfunction after Clinical Recovery from Chlorpromazine JaundiceThe liver and Its DiseasesSevere Hemolytic Reaction to Chlorpromazine 1 July 1960Volume 53, Issue 1Page: 116-146KeywordsAllergy and immunologyAminotransferasesAntigensChlorpromazineHormonal therapyHormonesLiver function testsMedical servicesPathogenesisZinc Issue Published: 1 July 1960 PDF downloadLoading ...