tbuckley/cabot-search huggingface dataset:
Dispersion of Ventricular Depolarization-Repolarization
Authors: Pietro Turrini, Domenico Corrado, Cristina Basso, Andrea Nava, Barbara Bauce, Gaetano Thiene
Journal: Circulation (2001)

We retrospectively investigated the value of clinical and ECG findings as well as QT-QRS dispersion in predicting the risk of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC).Duration and interlead variability of the QT interval and QRS complex were measured manually from standard ECGs in 20 sudden death victims with ARVC diagnosed at autopsy (group I), in 20 living ARVC patients with sustained ventricular tachycardia (group II), in 20 living ARVC patients with </=3 consecutive premature ventricular beats (group III), and in 20 control subjects (group IV). QT and QRS dispersions were greater in group I (77.5+/-10.6 ms for QT and 45.7+/-8.1 ms for QRS) compared with group II (64.5+/-13.9 ms for QT [P=0.001] and 33.5+/-8.7 ms for QRS [P=0.0004]) and in group II compared with group III (48+/-8.9 ms for QT [P<0.0001] and 28+/-5.2 ms for QRS [P<0.0001]) and group IV (33.5+/-4.8 ms for QT [P<0.0001] and 18.5+/-3.6 ms for QRS [P<0.0001]). Negative T wave beyond V(1) and syncope were statistically more frequent in group I (P=0.02 and P=0.007, respectively). On multivariate analysis, QRS dispersion remained an independent predictor of sudden death (P<0.0001), followed by syncope (P=0.09). In assessing risk of sudden death, QRS dispersion >/=40 ms had a sensitivity and specificity of 90% and 77%, respectively; QT dispersion >65 ms, 85% and 75%, respectively; negative T wave beyond V(1), 85% and 42%, respectively; and syncope, 40% and 90%, respectively.QRS dispersion (>/=40 ms) was the strongest independent predictor of sudden death in ARVC. Syncope, QT dispersion >65 ms, and negative T wave beyond V(1) refined arrhythmic risk stratification in these patients.
Cancer drug may join the AIDS arsenal
Authors: R. Voelker
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Points: Unexplained acute backache in longstanding ankylosing spondylitis
Authors: M I D Cawley
Journal: BMJ (1986)

Dr. Butler claims that I have "further-tarnished the reputation of Chile," nd he recommends that "further interchange ofdoctors takes placeso.thatmore people -may appreciate the freedom enjoyed by medical staff there, thus destrying the.ppular nusconceptions represented by thisarticle."My artcle did inl actcontai a strong plea that the medical professiot should not ostracise Chile, and that more British doctors should consier -ex- changes there.Aisl said in the article, this *will-e helpful to the profession in Chile.Whether it wl achieve Dr Eutler's intention of helping "more people-to appreciate the f0eedonm enjoyed 0-by medical staff there, thus destroying popglar mis- conceptions as perpetuated by this article" is more than doubtful.
Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma
Authors: Paola Bonetti, Monica Testoni, Marta Scandurra, Maurilio Ponzoni, Roberto Piva, Afua A. Mensah, Andrea Rinaldi, Ivo Kwee, Maria Grazia Tibiletti, Javeed Iqbal, Timothy C. Greiner, Wing-Chung Chan, Gianluca Gaidano, Miguel A. Piris, Franco Cavalli, Emanuele Zucca, Giorgio Inghirami, Francesco Bertoni
Journal: Blood (2013)
APPLICABILITY, LIMITATIONS AND IMPACT OF ECHOCARDIOGRAPHY UTILIZATION BASED ON THE 2007 APPROPRIATENESS USE CRITERIA FOR TRANSTHORACIC AND TRANSESOPHAGEAL ECHOCARDIOGRAPHY AT A TERTIARY CARE MEDICAL CENTER
Authors: Jayanth Koneru, Mohammad Al Qarqaz, Karthikeyan Ananthasubramaniam
Journal: Journal of the American College of Cardiology (2010)
RESISTANCE TO CLOPIDOGREL ASSESSED BY VASP PHOSPHORYLATION IS A NEGATIVE PROGNOSTIC FACTOR IN PATIENTS UNDERGOING ELECTIVE PCI FOR STABLE CORONARY ARTERY DISEASE: ANALYSIS FROM LABORATORY SUBSTUDY OF PRAGUE 8 TRIAL
Authors: Robert Petr, Zuzana Motovska, Iuri Marinov, Danuse Bilkova, Petr Widimsky
Journal: Journal of the American College of Cardiology (2010)
969. Bone Marrow Derived Endothelial Progenitor Cells Engineered by Lentiviral Vectors as Therapeutic Antitumoral Strategy
Authors: Veronica Fernandez, Milosz Kawa, Guanhua Yang, Jesus Prieto, Cheng Qian
Journal: Molecular Therapy (2006)

Endothelial progenitor cells (EPCs) are considered to contribute to the development of tumor neovascularization. It may be hypothesized that genetically engineered EPCs capable to express desired gene products inside the tumor mass may serve as potential anticancer therapy. In the present study, we investigated the recruitment of EPCs transduced by lentiviral vector in the tumor models. Murine EPC were isolated from bone marrow of C57BL/6 mice and cultured in endothelial growth factor enriched medium. The EPCs were transduced with lentiviral vectors encoding green fluorescent protein (GFP) and luciferase reporter genes. Subcutaneous and intrahepatic tumors were developed by direct injection of MC38 cells. Seven days after tumor cells implantation, genetically modified EPC were injected intravenously into C57BL/6 mice. Recruitment of EPC was examined at different time points by immunohistochemistry and bioluminescence assays. We obtained bone marrow-derived EPC after 4 days in culture with EPC medium. The EPCs were VEGFR-2+, Sca-1+, MECA-32+ and presented endothelial characteristics as Ulex lectin binding and LDL-cholesterol uptake. EPCs can be transduced with lentiviral vectors without affecting their viability. Immunohistochemical and immunofluorescence analysis showed that EPCs were incorporated in the surrounding stromal areas of tumor nodules. The in vivo imaging for luciferase expression showed that the maximal recruitment of EPCs in tumors occurred at 4th day after administration of EPCs. The biodistribution of EPCs revealed that tumor tissue showed higher luciferase activity compared to other organs. These results suggest that administration of lentiviral modified EPCs can be used as vehicles with therapeutical genes for therapy against solid tumors.
A survey of intravenous drug administration by preregistration house officers.
Authors: K Teahon, D N Bateman
Journal: BMJ (1993)

people from ethnic minorities comprise some 6X2% of the population of England.Both the 1989 and 1992 surveys show an ethnic minority presence on health authorities considerably below this level.They also indicate a decline over the period in ethnic minority membership of regional health authorities and in Afro- Caribbean membership of district health authorities.This may, in part, reflect the enhanced role of execu- tive positions and the disappearance of local authority and generalist members.Indeed, reorganisation was intended to make health authorities more managerial with less emphasis on representation.Nevertheless, Department of Health guidance specifically enjoins authorities to seek "a greater proportion of women and candidates from ethnic minority groups..."3 and suggests that district authorities should play important local advocate functions in making the National Health
POSSIBLE ERRORS IN THE DIAGNOSIS OF RENAL TUBERCULOSIS
Authors: WILLIAM F. BRAASCH
Journal: JAMA (1924)

Renal tuberculosis is recognized clinically without much difficulty when the usual clinical data are present. Unfortunately, however, the diagnosis of the disease is frequently obscured, either by the absence of any clinical data indicative of involvement of the urinary tract, or by the presence of data that are suggestive of conditions other than tuberculosis. The number of cases of renal tuberculosis with atypical symptoms in which the diagnosis was made in the course of routine clinical examination is increasing with the development in accuracy of clinical diagnosis. On the other hand, the existence of renal tuberculosis is undoubtedly often overlooked, in spite of careful clinical examination.  RELATIVE IMMUNITY  The degree of severity of subjective symptoms resulting from renal tuberculosis is largely dependent on the patient's resistance. Patients are observed who have such a high degree of resistance that an advanced tuberculous process may be present in the kidney without causing
High‐dose methylprednisolone in children with acute nonlymphoblastic leukemia
Authors: G. Hicsönmez, S. Özsoylu
Journal: American Journal of Hematology (1990)

High-Dose Methylprednisolone in Children With Acute Nonlymphoblastic LeukemiaWe read with interest the paper by Motoji et al. entitled "Successful treatment of refractory anemia with high-dose methylprednisolone" [ 13.Although they were successful in the treatment of some patients with refractory anemia (RA) with high-dose methylprednisolone (1,000 mg daily for 3 days), no improvement was observed in patients who had refractory anemia with an excess of myeloblast (RAEB).Recently, we have obtained remarkable antileukemic effect with high-dose intravenous methylprednisolone (HIVMP) in children with acute nonlymphoblastic leukemia (ANLL).Complete remission was achieved with HIVMP treatment without using any other antileukemic agents [ 2 4 ] .In our study methylprednisolone was administered in a dose of 30 or 20 mg/kg/day for at least 2 weeks; each dose given in 2-5 min.Therefore the difference of the dosage and the duration of HIVMP administration from our trial could be taken into consideration for the ineffectiveness of their treatment in patients with RAEB.More effective results on the proliferation of mouse myeloid leukemic cells had been also shown in vitro by using much higher than the physiological concentration of glucocorticoids or prolongation of its duration [ 5 ] .From these observations we assume that steroid dosage and the duration of its administration would be very important for achieving successful results in patients with RAEB.The mechanisms of the HIVMP effect on ANLL patients are not clear.However, the differentiation effect of steroid on some mouse myeloid leukemic cell [6,7] and the inhibition of leukemia associated inhibitor from human myeloid leukemic cells was shown in vitro [8], which supports our findings.In addition, with HIVMP, restoration of normal hematopoiesis as indicated by Motoji et al. could also be possible in patients with ANLL.Because of the above considerations, we suggest HIVMP treatment for patients with RAEB as was used in our trial.
Herpesvirus colitis: a new cause of diarrhoea in a patient with Hodgkin's disease.
Authors: A J Boulton, D N Slater, B W Hancock
Journal: Gut (1982)

A 57 year old woman developed severe diarrhoea during chemotherapy for Hodgkin9s lymphoma. Extensive colonic ulceration was observed at necropsy and electron microscopy showed intranuclear virions consistent with herpesvirus infection. Antibody titres and immunoperoxidase studies indicated that the virus was probably herpes simplex.
Comparison of saphenous vein graft intervention with bare stents plus distal protection versus membrane-covered stents without distal protection: Data from SAFER and roll-in phase of BARRICADE trials
Authors: Heidar Arjomand, Bassam Roukoz, Satish Surabhi, Andrey Espinoza, Marc Cohen, Gregg W. Stone, Donald S. Baim, Zoltan G. Turi, Sheldon Goldberg
Journal: Journal of the American College of Cardiology (2003)
Best books on orthopaedics: a personal choice
Authors: C M C. Brown
Journal: BMJ (1995)

Orthopaedic surgery is awash with books. One of the major medical book suppliers lists 532 available texts, 87.3% of which have been published since 1990. This situation has arisen largely because of rapid subspecialisation. One of the main problems in modern orthopaedics is that many surgeons want to be specialists, and this is reflected in the increasing numbers of esoteric specialist books and the decreasing numbers of books on “general” orthopaedic surgery.

** Turek's Orthopedics: Principles and their Application. 5th edn. Eds S Weinstein, J Buckwalter. (£95.) Lippincott, 1994. ISBN 0-397-50692-9

\***| Campbell's Operative Orthopedics. 8th edn. Ed A H Crenshaw. (£393.) Mosby/Year Book, 1992. ISBN 0-8016-1096-6

** Atlas of Orthopaedic Surgical Approaches. Eds C L Colton, A J Hall. (£25.) Butterworth Heinemann, 1991. ISBN 0-7506-1702-0

\***| Standard Orthopaedic Operations. 4th edn. J Crawford Adams. (£80.) Churchill Livingstone, 1992. ISBN 0-443-03232-7

** Children's Orthopaedics and Fractures. Eds M K D Benson, J A Fixen, M F Macnicol. (£75.) Churchill Livingstone, 1994. ISBN 0-443-04372-8

\***| Rockwood and Green's Fractures in Adults. 3rd edn. Eds C A Rockwood, D A Green, R W Bucholz. (£292.) Lippincott, 1991. ISBN 0-397-50975-8

* Skeletal Trauma. Eds B D Browner, J …
COMPARATIVE EFFECTIVENESS OF LEFT VENTRICULAR VERSUS BIVENTRICULAR PACING FOR CARDIAC RESYNCHRONIZATION THERAPY: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Pasquale Santangeli, Andrew Epstein, Mathew Hutchinson, Erica Zado, Daniele Muser, David J. Callans, Francis Marchlinski
Journal: Journal of the American College of Cardiology (2014)
Broad-Spectrum Sunscreen Use and the Development of New Nevi in White Children
Authors: Richard P. Gallagher, Jason K. Rivers, Tim K. Lee, Chris D. Bajdik, David I. McLean, Andrew J. Coldman
Journal: JAMA (2000)

High nevus density is a risk factor for cutaneous malignant melanoma. Melanocytic nevi originate in childhood and are largely caused by solar exposure.To determine whether use of broad-spectrum, high-sun protection factor (SPF) sunscreen attenuates development of nevi in white children.Randomized trial conducted June 1993 to May 1996.A total of 458 Vancouver, British Columbia, schoolchildren in grades 1 and 4 were randomized in 1993. After exclusion of nonwhite children and those lost to follow-up or with missing data, 309 children remained for analysis. Each child's nevi were enumerated at the start and end of the study in 1996.Parents of children randomly assigned to the treatment group (n=222) received a supply of SPF 30 broad-spectrum sunscreen with directions to apply it to exposed sites when the child was expected to be in the sun for 30 minutes or more. Children randomly assigned to the control group (n=236) received no sunscreen and were given no advice about sunscreen use.Number of new nevi acquired during the 3 years of the study, compared between treatment and control groups.Children in the sunscreen group developed fewer nevi than did children in the control group (median counts, 24 vs 28; P=.048). A significant interaction was detected between freckling and study group, indicating that sunscreen use was much more important for children with freckles than for children without. Modeling of the data suggests that freckled children assigned to a broad-spectrum sunscreen intervention would develop 30% to 40% fewer new nevi than freckled children assigned to the control group.Our data indicate that broad-spectrum sunscreens may attenuate the number of nevi in white children, especially if they have freckles. JAMA. 2000.
HERNIA OF THE OVARY AND TUBE.
Authors: FRANK T. ANDREWS
Journal: JAMA (1906)

Having already published an article on hernia of the tube without the ovary,<sup>1</sup>and having presented a paper on hernia of the uterus to the American Gynecological Society, I wish now to submit, tabulate and analyze the recorded cases of hernia of the ovary and Fallopian tube, leaving the subject of hernia of the ovary without the tube for a future paper. Through the kindness of my friend, Dr. Cullen of Baltimore, I am able to present the following case with a drawing of the contents of the sac. M., Cambridge, March 26, 1902. Child eight years of age suffering from left inguinal hernia. The hernial opening was about 1.5 cm. in diameter. The ring was exposed with considerable difficulty. A small oval mass was felt in the ring and the presence of the ovary immediately thought of. On opening the sac the ovary and tube were found adherent
CERTAIN MOTILE ORGANISMS IN THE BLOOD PLASMA IN DENGUE.
Authors: CONRAD REICHE
Journal: JAMA (1906)

While in charge of the laboratory of the military hospital in Cebu, P. I. (Captain Kulp) it was my duty to examine the blood of all malarial and dengue patients. An epidemic of the latter disease occurred during December, 1905, and lasted about six weeks. No malarial parasites were found, but I observed in nearly every case very active, small (about 2 micron), round translucent bodies, with clearly defined edges, very motile, and easily visible with a 1/6 objective, but better with 1/12 oil immersion lens. They were seldom or never found in the erythrocytes, but often on them, as well as free in the plasma. They appeared about the second day of the fever, and could never be found after the temperature became permanently normal or after the administration of quinin. They sometimes remained active for as long a period as an hour and three-quarters. Unfortunately, the epidemic ceased
Assessment of Myocardial Viability by Use of <sup>11</sup> C-Acetate and Positron Emission Tomography
Authors: H. Georg Wolpers, Wolfgang Burchert, Jörg van den Hoff, Regina Weinhardt, Geert-J. Meyer, Paul R. Lichtlen
Journal: Circulation (1997)

Dual positron emission tomography (PET) imaging with a perfusion tracer and 18F-fluorodeoxyglucose (FDG) can detect myocardial viability. This approach may be replaced by a single 11C-acetate study, which enables quantification of both regional blood flow and oxidative metabolism. The significance of acetate-derived indexes for myocardial viability is examined.Thirty postinfarct patients with akinetic ventricular segments, a mean ejection fraction of 42 +/- 11%, and high-grade coronary obstructions were studied with serial 11C-acetate PET scanning before and 7 +/- 5 months after coronary revascularization. Acetate PET was tested against FDG and serial assessments of segmental wall motion. Sixty of 155 severely dysfunctional LV segments improved postoperatively, and regional blood flow increased. Flow estimates after revascularization suggested little fibrosis in reversible segments. At baseline, blood flows differed between normal myocardium, reversible dysfunction, and irreversible dysfunction (1.04 +/- 0.27, 0.73 +/- 0.18, and 0.43 +/- 0.18 mL.min-1.g-1, respectively; P < .001). Oxidative metabolic rates were reduced only in irreversibly injured LV segments. Multivariate analysis identified the acetate perfusion index as the only independent predictor of postoperative recovery. Its predictive accuracy was similar to that of FDG imaging but superior to indexes of flow-metabolic mismatch or oxidative metabolism.After myocardial infarction, quantitative indexes of perfusion and oxidative metabolism from acetate PET indicate a critical threshold beyond which tissue is irreversibly injured. Findings support the use of blood flow as a marker of myocardial viability in chronic postinfarct patients with modestly reduced ejection fractions.
Unwanted Pregnancy — Medicated Survival — The Metric Spoon
Authors: John Lister
Journal: New England Journal of Medicine (1969)

THE Abortion Act of 1968 with its so-called social clause, which allows a termination to be carried out if the child is likely to be born into unsuitable surroundings or if its arrival is likely to have an adverse effect on existing children in the family, has now been in operation for a full year. The way in which the Act is working has been the subject of much discussion. As critics of the proposed reforms predicted, there has been a large increase in the number of legally recorded abortions, and many abortionists who previously acted illegally can now do . . .
WITHDRAWN: Emergence of Epidemic Multi-Resistant Escherichia Coli Expressing Both CTX-M and Acquired CMY-2-Like Amp C Beta-Lactamases
Authors: A. Fox, D. Livermore, D. Orr, E. Fagan, J. Cheesbrough, K. Hopkins, N. Woodford, P. Kaufmann, P. Wilkinson, R. Hill, S. Ha Lau, S. James, S. Reddy
Journal: Journal of Infection (2006)
Delivery on Demand — A New Era of Gene Therapy?
Authors: Josef T. Prchal
Journal: New England Journal of Medicine (2003)

The discovery of the DNA code touched off an explosion of our knowledge of the molecular basis of human diseases and sparked ideas about treating inherited diseases with genes. Unfortunately, the first widely publicized attempt at gene therapy, in which the β-globin gene was injected into a patient with β-thalassemia, undertaken 20 years ago, failed because it was not based on an understanding of gene regulation. This ill-conceived experiment led to a public backlash and an unwarranted fear, bordering on hysteria, of recombinant-DNA research and its clinical applications. It soon became clear that identifying a gene sequence and a disease-causing . . .
Powdered Tantalum
Authors: J. A. Nadel, W. G. Wolfe, P. D. Graf, J. E. Youker, N. Zamel, J. H. M. Austin, W. A. Hinchcliffe, R. H. Greenspan, R. R. Wright
Journal: New England Journal of Medicine (1970)

Roentgenographic outlining of airways is a valuable diagnostic tool, but the usual contrast mediums have a number of disadvantages: they are not very radiopaque, so that the large volume of material introduced into airways interferes with pulmonary function; they may be toxic; they do not provide details of airway mucosa; and they are in liquid form and so do not adhere firmly to the airway wall. Therefore, we used a new method of opacifying airways by outlining them with powdered tantalum in 26 patients with serious lung disease. The small volume of contrast material required did not interfere with pulmonary function. Fine mucosal detail was obtained, and the contrast material was not dislodged by respiratory maneuvers. Microscopical studies of lung tissue in eight patients showed no inflammatory reaction. The excellence of powdered tantalum as a contrast material is explained by its inertness, radiopacity and adherence to airway mucosa.
General approach to the biological analysis of complex mixtures.
Authors: W G Thilly, J Longwell, B M Andon
Journal: Environmental Health Perspectives (1983)

The study of potential health effects of combustion effluents involves identifying the substances present and estimating the probable health hazards of each. Unfortunately, this second step cannot be done by using present techniques. Approximations of health hazards by bacterial and human cell assays are being used to set priorities for further biological studies and to suggest needs for modifications of combustion systems. The assumptions underlying this approximation are discussed, and several examples of combustion effluents are reviewed.