tbuckley/cabot-search huggingface dataset:
Blood Coagulation and Fibrinolysis in Relation to Coronary Heart Disease
Authors: C. Merskey, H. Gordon, H. Lackner, V. Schrire, B. J. Kaplan, R. Sougin-Mibashan, H. L. Nossel, A. Moodie
Journal: BMJ (1960)

ACUTE MYOCARDIAL INFARCTIONMEDBATSH RNA219 the patient's resumption of work then confronts the doctor.In general an early return to work is to be encouraged.So long as disabling symptoms persist-exertional pain or dyspnoea-a resumption of occupation may be out of the question.For those handicapped by a residual angina of effort, or even minor degrees of congestive failure, retirement from active work may be the only alternative.Recovering satisfactorily from the acute attack and having mild or only trivial symptoms when ambulant, the patient should in general be able to resume some form of active work after a month's convalescence-that is, in approximately eight weeks from the onset.The weeks elapsing after leaving hospital should be devoted to the recovery of physical fitness and improved muscular tone, skeletal and cardiac.Rehabilitation has its psychological as well as its
Genetic and histologic evidence for autophagy in asthma pathogenesis
Authors: Audrey H. Poon, Fazila Chouiali, Sze Man Tse, Augusto A. Litonjua, Sabah N.A. Hussain, Carolyn J. Baglole, David H. Eidelman, Ronald Olivenstein, James G. Martin, Scott T. Weiss, Qutayba Hamid, Catherine Laprise
Journal: Journal of Allergy and Clinical Immunology (2011)
Benefit of Bilateral Over Single Internal Mammary Artery Grafts for Multiple Coronary Artery Bypass Grafting
Authors: Masahiro Endo, Hiroshi Nishida, Yasuko Tomizawa, Hiroshi Kasanuki
Journal: Circulation (2001)

Background The aim of this study was to evaluate the performance of bilateral internal mammary artery (BIMA) grafts in isolated CABG. Methods and Results Beginning in April 1985, elective primary multiple CABG for multivessel disease was performed in 1131 patients. The early and late results of 688 patients who received single internal mammary artery (SIMA) grafts and 443 patients who received BIMA grafts were compared (median follow-up, 6.15 years). Hospital mortality was not significantly different in the SIMA (0.9%) and BIMA (0.9%) groups. Graft patency was 97.3% in the BIMA group and 94.3% in the SIMA group ( P &lt;0.0001). The 7-year repeated CABG–free rate was significantly higher in the BIMA group ( P =0.026). The 7-year new myocardial infarction–free rate in all patients tended to be higher in the BIMA group ( P =0.06). The hazard ratio for all death or repeated CABG in patients with ejection fractions &gt;0.4 and age &lt;71 years was lower in the BIMA group ( P =0.0499). Conclusions Our data suggest that the use of BIMA grafts in patients with in situ coronary artery anastomoses achieves a significantly higher repeated CABG–free rate in all patients compared with the use of SIMA.
Differential Mortality for Persons With Psychological Distress and Low Socioeconomic Status
Authors: Kenneth B. Wells, Jeanne Miranda
Journal: JAMA Internal Medicine (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 1082: Stochastic control of abnormal morphogenesis induced by the ErbB2 oncoprotein
Authors: Lixin Wang, Kevin Janes
Journal: Cancer Research (2012)

Abstract Activation of the receptor tyrosine kinase ErbB2 causes multiacinar structures in 3D culture that are reminiscent of early-stage breast tumors. The penetrance of the multiacinar phenotype is incomplete and random, and dimerization with other ErbB family members gives rise to quantitative differences in penetrance. Our goal is to understand the mechanism by which a multiacinus initiates and why only a random fraction of the cultured acini exhibit the morphogenetic defect when ErbB2 is activated. Our working hypothesis is that acute differences (dichotomies) in gene expression develop among acini and give rise to the distinct 3D phenotypes induced by ErbB2. The transcriptional dichotomies that exist before the appearance of the multiacinar phenoptype will be the ones most likely to control it. We are using a new technique, called “stochastic profiling,” that our lab developed for discovering transcriptional dichotomies in a seemingly uniform cell population. We have established single ErbB2 dimer clones with similar expression levels of ErbB2 and its dimerization partner. Expression of the ErbB2 constructs was also validated at the single-cell level in frozen acinar sections by RNA FISH. Laser capture microdissection was used to select a small number of cells (10-100 cells) from the fresh frozen 3D sections followed by RNA extraction and small-sample cDNA amplification. The amplification parameters were optimized for the ErbB2 clones in different culture formats. We observed good quantitative linearity and amplification efficiencies for a wide range of high- and low-abundance targets in a 2D-culture format. We are working to improve the amplification efficiency of samples microdissected in the 3D-culture format. The long-term goal is to link upstream acinus-specific expression programs to downstream morphogenetic heterogeneities. The results from this project could explain mechanistically why only a fraction of ErbB2-overexpression breast cancers respond positively to ErbB2-targeted therapeutics. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1082. doi:1538-7445.AM2012-1082
Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset.
Authors: R Hirsch, M Lethbridge-Cejku, W W Scott, R Reichle, C C Plato, J Tobin, M C Hochberg
Journal: Annals of the Rheumatic Diseases (1996)

To examine the association between hand and knee osteoarthritis (OA) in a community based population.Radiographs of 695 participants aged > or = 40 years in the Baltimore Longitudinal Study of Aging were read for changes of OA, using Kellgren-Lawrence grade > or = 2 as the case definition.Logistic regression analyses, adjusting for age, gender and body mass index, revealed a significant association between OA in the knee and the following joint groups: distal and proximal interphalangeal (DIP, PIP) and Hand2 (OA in two or more hand joint groups) for grade 2-4 and grade 3-4 disease, and the first carpometacarpal (CMC1) joint for grade 3-4 disease.There is an association between OA in hand sites and the knee. The strength of the associations increases with increasing disease severity. For the PIP site, there is a trend toward increasing strength of association for increasing numbers of affected joints and bilateral disease.
Urine C-Peptide After Recovery from Diabetic Ketoacidosis: An Index of Insulin Dependency
Authors: Ayako Matsuda, Takeshi Kuzuya
Journal: Diabetes Care (1982)

C-peptide immunoreactivity (CPR) in 24-h urine was assayed in 13 diabetic patients during and after recovery from ketoacidosis. In 10 patients who remained insulin-dependent on discharge and in the subsequent follow-up period, urine CPR was low (18 micrograms/day or less), while in three patients who were ultimately controlled by diet or sulfonylureas, urine CPR was normal (59-92 micrograms/day, normal value 74 +/- 26 micrograms/day). In the latter group, urine CPR in one patient assayed during ketoacidosis was 6 micrograms/day and, in another patient, it was 22 micrograms/day on the 3rd day of the admission. This may imply that in the latter group, B-cell function was decompensated in ketoacidosis, but was restored after recovery. Clinical courses suggested that these patients were not in the remission phase of IDDM, but belonged to NIDDM. Among other groups of diabetic patients, urine CPR in those treated with diet or sulfonylureas was 72 +/- 30 micrograms/day and always higher than 20 micrograms/day. The prevalence of urine CPR less than 20 micrograms/day was more frequent in those with younger onset of diabetes, higher insulin dosage, unstable diabetes, or previous history of ketoacidosis among insulin-treated patients. We suggest that urine CPR less than 20 micrograms/day is an index of insulin dependency, although in a state of extreme decompensation of B-cells such as in ketoacidosis, urine CPR can be decreased low even in NIDDM.
Brazil fights to save biodiversity
Authors: J Rocha
Journal: BMJ (1994)

Brazilian scientists are worried about the destruction of the Amazon rainforest and the smuggling out of plants by foreign researchers.

At the “earth summit” in Rio de Janeiro last year Brazil's former environment secretary, Jose Lutzenberger, warned, “The pharmaceutical companies have hundreds of researchers combing forests throughout the world, talking to Indians to discover plants with medicinal qualities, and sending back botanical material. Then we shall have to pay royalties to use the medicines developed from them.”

At the …
Do Human Milk Concentrations of Persistent Organic Chemicals Really Decline During Lactation? Chemical Concentrations During Lactation and Milk/Serum Partitioning
Authors: Judy S. LaKind, Cheston M. Berlin, Andreas Sjödin, Wayman Turner, Richard Y. Wang, Larry L. Needham, Ian M. Paul, Jennifer L. Stokes, Daniel Q. Naiman, Donald G. Patterson
Journal: Environmental Health Perspectives (2009)

Conventional wisdom regarding exposures to persistent organic chemicals via breast-feeding assumes that concentrations decline over the course of lactation and that the mother's body burden reflects her cumulative lifetime exposure. Two important implications stemming from these lines of thought are, first, that assessments of early childhood exposures should incorporate decreasing breast milk concentrations over lactation; and, second, that there is little a breast-feeding mother can do to reduce her infant's exposures via breast-feeding because of the cumulative nature of these chemicals.We examined rates of elimination and milk/serum partition coefficients for several groups of persistent organic chemicals.We collected simultaneous milk and blood samples of 10 women at two times postpartum and additional milk samples without matching blood samples.Contrary to earlier research, we found that lipid-adjusted concentrations of polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and furans, and organochlorine pesticides in serum and milk do not consistently decrease during lactation and can increase for some women. Published research has also suggested an approximate 1:1 milk/serum relationship (lipid adjusted) on a population basis for 2,3,7,8-tetrachlorodibenzo-p-dioxin; however, our results suggest a more complex relationship for persistent, lipophilic chemicals with the milk/serum relationship dependent on chemical class.Decreases in concentration of lipophilic chemicals on a lipid-adjusted basis during lactation should no longer be assumed. Thus, the concept of pumping and discarding early milk as means of reducing infant exposure is not supported. The hypothesis that persistent lipophilic chemicals, on a lipid-adjusted basis, have consistent concentrations across matrices is likely too simplistic.
Myocardial Infarction and Cardiac Mortality in the Bypass Angioplasty Revascularization Investigation (BARI) Randomized Trial
Authors: Bernard R. Chaitman, Allan D. Rosen, David O. Williams, Martial G. Bourassa, Frank V. Aguirre, Bertram Pitt, Pentti M. Rautaharju, William J. Rogers, Barry Sharaf, Michael Attubato, Regina M. Hardison, Sanjay Srivatsa, Nicholas T. Kouchoukos, Karen Stocke, George Sopko, Katherine Detre, Robert Frye
Journal: Circulation (1997)

Background Cardiac mortality and myocardial infarction (MI) rates are used to evaluate the efficacy of coronary artery bypass grafting (CABG) and percutaneous transluminal coronary angioplasty (PTCA). We compared 5-year cardiac mortality and MI rates in 1829 patients with multivessel disease randomized to CABG or PTCA. Methods and Results The 5-year cardiac mortality rate was 8.0% in patients assigned to PTCA compared with 4.9% in those assigned to CABG (relative risk [RR] of 1.55 with a 95% confidence interval [CI] of 1.07 to 2.23; P =.022). In a subgroup of 1476 nondiabetic patients, there were no significant differences between treatment groups in cardiac mortality either overall (4.6% versus 4.2%; RR=1.04, 95% CI, 0.65 to 1.66; P =.908) or in subgroups based on symptoms, left ventricular function, number of diseased vessels, or stenotic proximal left anterior descending artery. The two treatment groups had similar event rates for the combined end point of cardiac death or MI. The RR for cardiac mortality in 264 patients who sustained an MI compared with those who did not was 5.9 ( P &lt;.001). MIs were more common after CABG during index hospitalization ( P =.004), but in the PTCA group, they were more common after discharge ( P &lt;.001). Conclusions The Bypass Angioplasty Revascularization Investigation (BARI) trial indicates 5-year cardiac mortality in patients with multivessel disease was significantly greater after initial treatment with PTCA than with CABG. The difference was manifest in diabetic patients on drug therapy. There were no significant differences overall for the composite end point of cardiac mortality or MI between treatment groups or for cardiac mortality in nondiabetic patients regardless of symptoms, left ventricular function, number of diseased vessels, or stenotic proximal left anterior descending artery.
Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: analysis of a series of 432 patients
Authors: Sandra Quijano, Antonio López, Ana Rasillo, Susana Barrena, Maria Luz Sánchez, Juan Flores, Carlos Fernández, José María Sayagués, Carlos Salvador Osuna, Nuria Fernández, Marcos González, Pilar Giraldo, Manuel Giralt, Maria Carmen Pérez, José Manuel Martin-Antoran, Oliver Gutiérrez, Luis Perdiguer, Joaquín Díaz Mediavilla, Manuel González Silva, Agustín Asensio del Rio, Carlos Cerveró, José Luis Guerra, Rosario Butrón, Maria del Carmen García, Julia Almeida, Alberto Orfao
Journal: Blood (2008)
Lower Airway Inflammation in Infants and Young Children with Cystic Fibrosis
Authors: DAVID S. ARMSTRONG, KEITH GRIMWOOD, JOHN B. CARLIN, ROSEMARY CARZINO, JOSE P. GUTIÈRREZ, JEREMY HULL, ANTHONY OLINSKY, ETHNA M. PHELAN, COLIN F. ROBERTSON, PETER D. PHELAN
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Airway inflammation is an important component of cystic fibrosis (CF) lung disease. To determine whether this begins early in the illness, before the onset of infection, we examined bronchoalveolar lavage (BAL) fluid from 46 newly diagnosed infants with CF under the age of 6 mo identified by a neonatal screening program. These infants were divided into three groups: 10 had not experienced respiratory symptoms or received antibiotics and pathogens were absent in their BAL fluid; 18 had clear evidence of lower respiratory viral or bacterial ( ⩾ 105 CFU/ml) infection; and the remaining 18 had either respiratory symptoms, taken antibiotics, or had < 105 CFU/ml of respiratory pathogens. Their BAL cytology, interleukin-8, and elastolytic activity were compared with those from 13 control subjects. In a longitudinal study to assess if inflammation develops or persists in the absence of infection, the results of 56 paired annual BAL specimens from 44 CF infants were grouped according to whether they showed absence, development, clearance, or persistence of infection. In newly diagnosed infants with CF, those without infection had BAL profiles comparable with control subjects while those with a lower respiratory infection had evidence of airway inflammation. In older children, the development and persistence of infection was accompanied by increased inflammatory markers, whereas these were decreased in the absence, or with the clearance, of infection. We conclude that airway inflammation follows respiratory infection and, in young children, improves when pathogens are eradicated from the airways.
Letter: Gamekeeper's thumb on the ski slopes.
Authors: W A Fraser-Moodie
Journal: BMJ (1974)

this risk-and at the least avoid prolonged pregnancy.The second item concerns our doubleblind trial of chlorpropamide 100 mg a day in the treatment of gestational chemical diab_tes in women of average body weight.We do know that such a dose of ohlorpropamide is effective in reversing chemical diabetes in the mother in pregnancy-without apparent harm to the fetus4-though we do not recommend this form of treatmenit for diabetes of a more severe degree, wh-ich seems to require more delicate oDntrol during pregnancy.5-Weare, etc.,
TRANSIENT VISUAL SYMPTOMS ASSOCIATED WITH MELLARIL MEDICATION
Authors: S. BERGEN MORRISON
Journal: American Journal of Psychiatry (1960)

A case is presented in which a patient complained bitterly of blurring of vision when coming in from out of doors while receiving Mellaril and after having received approximately 30 grams of Mellaril over a period of 2½ months. The visual complaint cleared over a period of approximately 4 weeks after the Mellaril had been stopped. It is suggested that this is an early toxic reaction to Mellaril of the type seen previously with an experimental phenothiazine called NP-207.
Regulation of cardiac contractile proteins. Correlations between physiology and biochemistry.
Authors: S Winegrad
Journal: Circulation Research (1984)

Modulation of the functional properties of the contractile proteins of mammalian heart muscle plays a significant role in the response of the heart to beta-adrenergic stimulation. The most well understood modification is a change in the concentration of calcium ions that is required to activate the contractile system. By means of a cAMP-sensitive phosphorylation of the inhibitory subunit of troponin (TNI), the threshold concentration for activation can be increased as much as 5-fold without changing the maximum calcium-activated force. The protein kinase involved in this regulation is located in the sarcolemma. Cholinergic stimulation causes a dephosphorylation of TNI by a cGMP-sensitive phosphatase. The concentration of calcium ions required to activate contraction also decreases as muscle length increases. This response of the contractile proteins does not involve phosphorylation of TNI. Regulation of the maximum calcium-activated force can take place by a cAMP-sensitive reaction involving a different protein kinase that is located inside the cell. This mechanism involves at least two sequential reactions, one a cAMP-controlled phosphorylation of a protein bound to an intracellular membrane to release an active factor, and the second, an interaction between the active factor and the contractile proteins to enhance the capacity for generating force in the presence of calcium. Phosphorylation of the light chain of myosin is produced by a calmodulin-regulated kinase. The light chain of myosin is partially phosphorylated in the intact heart, but beta-adrenergic stimulation of the heart does not increase the decrease of phosphorylation in parallel with the increase in contractility.
Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice
Authors: H. Yokoi, M. Mukoyama, K. Mori, M. Kasahara, T. Suganami, K. Sawai, T. Yoshioka, Y. Saito, Y. Ogawa, T. Kuwabara, A. Sugawara, K. Nakao
Journal: Kidney International (2007)
Abstract B61: Proteomic profiling of ovarian cancer and mesothelial cells reveals novel mediators implicated in the metastatic progression of ovarian cancer to the peritoneum
Authors: Natasha Musrap, George S. Karagiannis, Eleftherios P. Diamandis
Journal: Clinical Cancer Research (2013)

Abstract Over the past decade, numerous studies have highlighted the impact of the cancer microenvironment on tumor progression. It is now well understood that tumor cell behaviour is largely influenced by various stromal cell types and extracellular matrix components within their surrounding environments. A key hallmark of epithelial ovarian cancer (EOC) progression is the attachment of cancerous cells to the mesothelium and the formation of invasive peritoneal implants. Given that metastatic dissemination to the peritoneum is associated with poor prognosis, delineating the factors involved in cancer-peritoneal cell interaction, and the mechanisms they employ, is vital to improving patient survival as it may lead to the discovery of novel therapeutic targets. As such, we aimed to elucidate proteins that participate in this interaction by comparing the secreted proteome (referred to as the secretome) of an in vitro co-culture model containing ovarian cancer (OVCAR-5) and mesothelial cells (LP-9) to that of their monoculture secretomes. Using two-dimensional liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), we identified 1584 proteins that were secreted by co-cultures, and 1644 and 1420 proteins by OVCAR-5 and LP-9 cells, respectively. After comparative analysis and application of our filtering criteria, we identified 53 proteins that were differentially secreted during cancer and mesothelial interaction, and of these, mucin 5AC (MUC5AC) displayed significantly elevated secretion in the co-culture secretomes. Relative mRNA expression of candidates was assessed using quantitative PCR, which also revealed an increase in MUC5AC gene expression in three different co-culture models (OVCAR-5 and LP-9; BG-1 and LP-9; OV-90 and LP-9) (p&amp;lt;0.05). Immunocytochemistry analysis also revealed increased expression of MUC5AC in ovarian cancer and peritoneal co-cultures. Taken together, these findings reveal novel proteins that may potentially regulate the progression of ovarian cancer to the peritoneum, particularly MUC5AC, and elucidation of its role in EOC warrants further investigation. Citation Format: Natasha Musrap, George S. Karagiannis, Eleftherios P. Diamandis. Proteomic profiling of ovarian cancer and mesothelial cells reveals novel mediators implicated in the metastatic progression of ovarian cancer to the peritoneum. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B61.