Rheumatic Fever in Children and Adolescents: A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae: III. Comparative Effectiveness of Three Prophylaxis Regimens in Preventing Streptococcal Infections and Rheumatic Recurrences
Authors: HARRISON F. WOOD
Journal: Annals of Internal Medicine (1964)

Article1 February 1964Rheumatic Fever in Children and AdolescentsIII. Comparative Effectiveness of Three Prophylaxis Regimens in Preventing Streptococcal Infections and Rheumatic RecurrencesHARRISON F. WOOD, M.D., ALVAN R. FEINSTEIN, M.D., ANGELO TARANTA, M.D., JEANNE A. EPSTEIN, M.D., RITA SIMPSON, B.A.HARRISON F. WOOD, M.D., ALVAN R. FEINSTEIN, M.D., ANGELO TARANTA, M.D., JEANNE A. EPSTEIN, M.D., RITA SIMPSON, B.A.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-31 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe preceding report presented the aims, background, and methods of a large-scale study of three types of prophylaxis against streptococcal infections and recurrences of rheumatic fever (1). It described the characteristics of the 431 rheumatic children and adolescents who were studied in a large metropolitan area, the organization of the clinic, the procedures used to assign patients to the three prophylactic regimens in a statistically comparable manner, and certain preliminary results.The present report will assess the effectiveness of the three prophylactic regimens during the study, the numbers and rates of streptococcal infections and rheumatic fever recurrences, and the nature...References1. WOODSIMPSONFEINSTEINTARANTASTOLLERMAN HFRARAGH: Rheumatic fever in children and adolescents: a long-term epidemiologic study of subsequent prophylaxis, streptococcal infections, and clinical sequelae. I. Description of the investigative techniques and of the population studied. Ann. Intern. Med. 60: (Feb. Supp.) 6, 1964. LinkGoogle Scholar2. WOODSTOLLERMANFEINSTEINHIRSCHFELDRUSOFFTARANTAHAASEPSTEIN HFGHARIJHARCJA: A controlled study of three methods of prophylaxis against streptococcal infection in a population of rheumatic children. I. Streptococcal infection and recurrences of acute rheumatic fever in the first two years of the study. New Eng. J. Med. 257: 394, 1957. CrossrefMedlineGoogle Scholar3. FEINSTEINWOODEPSTEINTARANTASIMPSONTURSKY ARHFJAARE: Ibid. II. Results of the first three years of the study, including methods for evaluating the maintenance of oral prophylaxis. New Eng. J. Med. 260: 697, 1959. CrossrefMedlineGoogle Scholar4. WOODMCCARTY HFM: Laboratory aids in the diagnosis of rheumatic fever and in evaluation of disease activity. Amer. J. Med. 17: 768, 1957. CrossrefGoogle Scholar5. TARANTAWOODFEINSTEINSIMPSONKLEINBERG AHFARRE: Rheumatic fever in children and adolescents: a long-term epidemiologic study of subsequent prophylaxis, streptococcal infections, and clinical sequelae. IV. Relation of the rheumatic fever recurrence rate per streptococcal infection to the titers of streptococcal antibodies. Ann. Intern. Med. 60: (Feb. Supp.) 47, 1964. AbstractGoogle Scholar6. RANTZMARONEYDICAPRIO LAMJM: Hemolytic streptococcal infection in childhood. Pediatrics 12: 498, 1953. MedlineGoogle Scholar7. DIEHLLADEHAMILTON AMRITR: Epidemiology of rheumatic fever. Amer. J. Cardiol. 1: 481, 1944. Google Scholar8. POWERSBOISVERT GFPL: Age as a factor in streptococcosis. J. Pediat. 25: 481, 1944. CrossrefGoogle Scholar9. WOOD HF: Prevention of rheumatic fever. Amer. J. Cardiol. 1: 456, 1958. CrossrefMedlineGoogle Scholar10. COBURNMOORE AFLV: The prophylactic use of sulfonilamide in streptococcal respiratory infections, with especial reference to rheumatic fever. J. Clin. Invest. 18: 147, 1939. CrossrefMedlineGoogle Scholar11. THOMASFRANCE CBRA: A preliminary report of the prophylactic use of sulfonilamide in patients susceptible to rheumatic fever. Bull. Hopkins Hosp. 64: 67, 1939. Google Scholar12. KUTTNER AG: Prevention of recurrences of rheumatic fever. Advances Pediat. 2: 367, 1947. Google Scholar13. WILSON AT: An evaluation of chemo-prophylaxis of streptococcal infections in Evaluation of Chemo-Therapeutic Agents, edited by MACLEOD, C. M. A symposium held at New York Academy of Medicine, March, 1948. Columbia University Press, New York, 1949, p. 121. Google Scholar14. STOLLERMANLEWISSCHULTZTARANTA GHAJIA: Relationship of immune response to Group A streptococci to the course of acute, chronic and recurrent rheumatic fever. Amer. J. Med. 20: 163, 1956. CrossrefMedlineGoogle Scholar15. JOHNSONSTOLLERMANGROSSMANMCCULLOCH EEGHDJJ: Streptococcal infections in adolescents and adults after prolonged freedom from rheumatic fever. I. Results of the first three years of the study. New Eng. J. Med. 263: 105, 1960. CrossrefMedlineGoogle Scholar16. Treatment and prevention of streptococcal disease and its sequelae. Publications TB Med. 259, NAVMED P-5052-17, and AFP 160-5-24. Departments of the Army, the Navy, and the Air Force, Washington 25, D. C. May, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARRISON F. WOOD, M.D.; ALVAN R. FEINSTEIN, M.D.; ANGELO TARANTA, M.D.; JEANNE A. EPSTEIN, M.D.; RITA SIMPSON, B.A.Affiliations: Irvington-on-Hudson, New YorkFrom Irvington House, Irvington-on-Hudson, New York, and the Departments of Pediatrics and Medicine, New York University School of Medicine, New York.This work was supported in part by the National Heart Institute grant H-1595 (C-1-6), American Heart Association, New York Heart Association, Westchester Heart Association, Wyeth Laboratories, Sullivan County Heart Chapter, and the Genesee County Heart Chapter.Part of the work done by Dr. Taranta was during his tenure of an Advanced Research Fellowship of the American Heart Association.Dr. Wood is currently with the Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut. Dr. Feinstein is with the Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.Requests for reprints should be adddessed to Harrison F. Wood, M.D., Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven 11, Connecticut. 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WOOD, M.D., ESTHER TURSKY, R.N., RITA SIMPSON, B.A.Rheumatic Fever in Children and Adolescents A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae I. Description of the Investigative Techniques and of the Population StudiedHARRISON F. WOOD, M.D., RITA SIMPSON, B.A., ALVAN R. FEINSTEIN, M.D., ANGELO TARANTA, M.D., ESTHER TURSKY, R.N., GENE STOLLERMAN, M.D., F.A.C.P.Prophylaxis of rheumatic fever 1 February 1964Volume 60, Issue 2_Part_2Page: 31-46KeywordsAdolescentsChildrenFellowshipsHeartPediatricsProphylaxisRheumatic feverStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...