tbuckley/cabot-search huggingface dataset:
Visualization of Hypertrophied Papillary Muscle Mimicking Left Ventricular Mass on Gated Blood Pool and TI-201 Myocardial Perfusion Imaging
Authors: HISASHI BUNKO, KENICHI NAKAJIMA, NORIHISA TONAMI, HIDETSUGU ASANOI, KINICHI HISADA
Journal: Clinical Nuclear Medicine (1981)

A sixty–year–old man with acute myocardial infarction was incidentally found to have a hypertrophied anterolateral papillary muscle (ALPPM) of the left ventricle on gated blood pool (GBP) and TI-201 myocardial perfusion images. Hypertrophy of the ALPPM was visualized as a movable defect in the lateral basal area on GBP imaging throughout the cardiac cycle and on the TI-201 study as a radionuclide accumulating structure, consistent with the defect in the GBP. A combination of these findings may suggest the presence of a hypertrophied papillary muscle of the left ventricle.
VERY LATE STENT THROMBOSIS WITH BARE METAL STENTS COMPARED TO DRUG ELUTING STENTS AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: A META ANALYSIS OF PROSPECTIVE CLINICAL TRIALS
Authors: Rachit Shah, Rohit Bhuriya, Janos Molnar, Mukesh Singh, Tejaskumar Shah, Evyan Jawad, Sandeep Khosla
Journal: Journal of the American College of Cardiology (2012)
Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure
Authors: Antonio Abbate, Giuseppe G.L Biondi-Zoccai, Rossana Bussani, Aldo Dobrina, Debora Camilot, Florinda Feroce, Raffaele Rossiello, Feliciano Baldi, Furio Silvestri, Luigi M Biasucci, Alfonso Baldi
Journal: Journal of the American College of Cardiology (2003)
Maternal Malaria and Gravidity Interact to Modify Infant Susceptibility to Malaria
Authors: Theonest K Mutabingwa, Melissa C Bolla, Jin-Long Li, Gonzalo J Domingo, Xiaohong Li, Michal Fried, Patrick E Duffy
Journal: PLoS Medicine (2005)

In endemic areas, placental malaria due to Plasmodium falciparum is most frequent and severe in first-time mothers, and increases the risk of infant mortality in their offspring. Placental malaria may increase the susceptibility of infants to malaria parasitemia, but evidence for this effect is inconclusive.During 2002-2004, we monitored parasitemia in 453 infants, including 69 who were born to mothers with placental malaria, in a region of northeastern Tanzania where malaria transmission is intense. We used a Cox proportional hazards model to evaluate the time from birth to first parasitemia, and a generalized estimating equations logistic regression model to evaluate risk of any parasitemia throughout the first year of life. Compared with infants whose mothers did not have placental malaria at delivery ("PM-negative"), offspring of mothers with placental malaria at delivery ("PM-positive") were 41% more likely to experience their first parasitemia at a younger age (adjusted hazard ratio [AHR] = 1.41, 95% confidence interval [CI] 1.01-1.99). The odds of parasitemia throughout infancy were strongly modified by the interaction between placental malaria and gravidity (p for interaction = 0.008, Type 3 likelihood ratio test). Offspring of PM-negative primigravidae had lower odds of parasitemia during infancy (adjusted odds ratio [AOR] = 0.67, 95% CI 0.50-0.91) than offspring of PM-negative multigravidae, and offspring of PM-positive primigravidae had the lowest odds (AOR = 0.21, 95% CI 0.09-0.47). In contrast, offspring of PM-positive multigravidae had significantly higher odds of parasitemia (AOR = 1.59, 95% CI 1.16-2.17).Although parasitemia is more frequent in primigravid than multigravid women, the converse is true in their offspring, especially in offspring of PM-positive women. While placental malaria is known to increase mortality risk for first-born infants, it surprisingly reduced their risk of parasitemia in this study. Placental malaria of multigravidae, on the other hand, is a strong risk factor for parasitemia during infancy, and therefore preventive antimalarial chemotherapy administered to multigravid women close to term may reduce the frequency of parasitemia in their offspring.
Pituitary Adenoma and Cerebral Infarction Demonstrated by Tc-99m HMPAO Using a High-resolution SPECT System
Authors: TAKASHI TOGAWA, NOBUHARU YUI, HIROKI NAMBA, MAKIKO ISHIHARA, FUJIMI KINOSHITA, MASAKI KOAKUTSU
Journal: Clinical Nuclear Medicine (1992)

A Tc-99m HMPAO SPECT study was carried out on a patient with a cerebral infarction 16 days after the partial removal of a pituitary adenoma. Extensive right temporal hypoperfusion and distinct delineation of residual pituitary adenoma were shown. Although PET imaging with F-18 FDG or C-11 methionine has been used for the assessment of pituitary adenomas, a high-resolution SPECT system with Tc-99m HMPAO, which is commercially available, can also clearly demonstrate pituitary adenomas.
Episodic Dyscontrol: A Study of 130 Violent Patients
Authors: GEORGE BACH-Y-RITA, JOHN R. LION, CARLOS E. CLIMENT, FRANK R. ERVIN
Journal: American Journal of Psychiatry (1971)

The authors report a two-year study of 130 patients with a chief complaint of explosive violent behavior. When pertinent and possible, neurological and psychological tests, EEGs, pneumoencephalograms, and other tests were made. The authors noted that the patients' lives mirrored their backgrounds: family histories revealed a high incidence of violence and alcoholism. The patients reported that they had frequently sought help in the past for control of violent impulses, but usually in vain. The authors believe that severe psychopathology should not exclude neurological examination and management, nor should positive neurological findings exclude psychiatric management. A plea is made to view these patients as having a multidetermined problem.
Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia
Authors: Jason LeGrand, Eun Sung Park, Hongyang Wang, Shalu Gupta, James D. Owens, Patrick J. Nelson, Wendy DuBois, Thomas Bair, Siegfried Janz, J. Frederic Mushinski
Journal: Blood (2011)
Syrian refugees could bring polio to Europe, experts warn
Authors: S. Hives-Wood
Journal: BMJ (2013)

Two German public health experts have warned that Europe could be in danger of an outbreak of polio brought by Syrian refugees.

Martin Eichner and Stefan Brockman explained in a Lancet report that in European countries where vaccination coverage was low, such as Ukraine, Bosnia, and Austria, polio could be introduced back into the European Union from people fleeing the conflict in Syria.1

The director of the European Centre for Disease Prevention and Control, Marc Sprenger, agreed. He told the …
Rotavirus vaccine cuts deaths of Mexican babies from diarrhoea by 40%
Authors: A. Gulland
Journal: BMJ (2010)

The worldwide campaign to introduce the rotavirus vaccine has been given an important boost with the publication of two papers, one showing a drop in deaths from diarrhoeal disease in Mexico after the vaccine was introduced and the other proving its effectiveness among babies in Africa.

The findings from the two studies, published in the New England Journal of Medicine , informed the World Health Organization’s recent recommendation that rotavirus vaccine be included in every nation’s vaccination programme.

In an editorial accompanying the papers, Mathuram Santosham, professor of international health …
Debbie Purdy lodges appeal with House of Lords to prevent husband's prosecution in assisted suicide case
Authors: C. Dyer
Journal: BMJ (2009)

Debbie Purdy, who wants her husband to accompany her to Switzerland for an assisted suicide without fear of prosecution, took her case to the United Kingdom’s highest court, the House of Lords, for a final appeal this week.

Ms Purdy, who has progressive multiple sclerosis, scored an important victory on the first day of the two day hearing, when the director of public prosecutions, Keir Starmer, conceded that article 8 of the European Convention on Human Rights, the right to respect for private life, applies to cases like hers.

Up to that point the Director of Public Prosecutions had argued, following the House of Lords judgment in the similar case of …
The Search for a Lower Cesarean Rate Goes On
Authors: Harry S. Jonas
Journal: JAMA (1989)

When physicians alter their practice patterns or employ new technology, the result may have a significant impact on health care costs. The most important consideration, however, is whether a modification of practice pattern enhances the eventual medical outcome. Today's obstetrician employs cesarean delivery much more frequently than the practitioner of a generation ago, who was likely to consider a cesarean delivery rate of less than 5% a hallmark of good obstetric practice. The reasons for this dramatic change in the use of operative delivery, which now has reached a national level of almost 25%, are many and somewhat difficult to evaluate. Enhanced patient expectations for a perfect obstetric outcome have spurred the use of changing practice patterns and various new technologies, prior to and during labor and at the time of delivery. Once physician practice patterns are entrenched, they become difficult to modify in the absence of sound scientific studies
Once- versus twice-weekly bortezomib induction therapy with CyBorD in newly diagnosed multiple myeloma
Authors: Craig B. Reeder, Donna E. Reece, Vishal Kukreti, Christine Chen, Suzanne Trudel, Kristina Laumann, Joseph Hentz, Nicholas A. Pirooz, Jesus G. Piza, Rodger Tiedemann, Joseph R. Mikhael, Peter L. Bergsagel, Jose F. Leis, Rafael Fonseca, Alexander K. Stewart
Journal: Blood (2010)
Effects of Alcohol Consumption on Plasma and Urinary Hormone Concentrations in Premenopausal Women
Authors: M. E. Reichman, J. T. Judd, C. Longcope, A. Schatzkin, B. A. Clevidence, P. P. Nair, W. S. Campbell, P. R. Taylor
Journal: JNCI Journal of the National Cancer Institute (1993)

Background : Most epidemiologic studies of the relationship between alcohol consumption and breast cancer risk over the past decade have shown that persons who consume a moderate amount of alcohol are at 40%-100% greater risk of breast cancer than those who do not consume alcohol. Dose-response effects have been observed, but no causal relationship has been established. Purpose : This study examines the hypothesis that alcohol consumption affects levels of reproductive hormones. Methods : A controlled-diet study lasting for six consecutive menstrual cycles was conducted. Participants were randomly assigned to two groups, and a crossover design was used. During the last three menstrual cycles, alcohol consumption of the two groups was reversed. Thirty-four premenopausal women, aged 21–40 years, with a history of regular menstrual cycles, consumed 30 g of ethanol (equivalent to approximately two average drinks) per day for three menstrual cycles and no alcohol for the other three. All food and alcohol consumed were provided by the study. Caloric intake was monitored to ensure that each woman would maintain body weight at approximately the baseline level. Hormone assays were performed on pooled plasma or 24-hour urine specimens collected during the follicular (days 5–7), peri-ovulatory (days 12–15), and mid-luteal (days 21–23) phases of the third menstrual cycle for subjects on each diet. Results : Alcohol consumption was associated with statistically significant increases in levels of several hormones. Plasma dehydroepiandrosterone sulfate levels were 7.0% higher in the follicular phase ( P =.05). In the peri-ovulatory phase, there were increases of 21.2% ( P =.01) in plasma estrone levels, 27.5% ( P =.01) in plasma estradiol levels, and 31.9% ( P =.009) in urinary estradiol levels. In the luteal phase, urinary estrone levels rose 15.2% ( P =.05), estradiol levels increased 21.6% ( P =.02), and estriol levels rose 29.1% ( P =.03). No changes were found in the percent of bioavailable estradiol, defined by the sum of percent free estradiol and percent albumin-bound estradiol. However, increased total estradiol levels in the peri-ovulatory phase suggest elevated absolute amounts of bioavailable estradiol. Conclusion : This study has shown increases in total estrogen levels and amount of bioavailable estrogens in association with alcohol consumption in pre-menopausal women. Implication : This possible explanatory mechanism for a positive association between alcohol consumption and breast cancer risk merits further investigation. [J Natl Cancer Inst 85: 722–727, 1993]
Dr Johann Faust
Authors: George E. Ehrlich
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Recently,The Journalfeatured a brief discussion of a stamp commemorating the original Dr Faust.<sup>1</sup>He became subject to a legend that he was in league with the devil and that he sold his soul to become young again. This prototypical figure is treated in many ways, some emphasizing the romantic aspects of his rejuvenation, some the philosophic aspects of age, and some the mysterious power of thought. The bare-bones description of Faust and the stamp fail to do justice to the inspirational quality of the legend. Not only Gounod wrote an opera based on the subject, but also Spohr, Busoni, Berlioz, and Boito, to name only some of those still heard. Thomas Mann wrote a novel based on the subject, Wagner an overture, and many others poems and stories. The real Faust was a contemporary of Johann Weyer, the father of psychiatry, and lived in
Hypertension following denervation of aortic baroreceptors in unanesthetized dogs.
Authors: C S Ito, A M Scher
Journal: Circulation Research (1979)

After cervical aortic nerve section, mean arterial pressure in the unanesthetized dog increased by an average of 7.4 mm Hg. Following a more extensive denervation of aortic arch receptors by section of intrathoracic vagal branches, arterial pressure increased by 16.7 mm Hg. The above changes were seen in the stable state after the effects of surgery had disappeared. In both cases carotid baroreceptors were functional. After administration of nitroglycerin and phenylephrine subsequent to either denervation procedure, blood pressure changes were larger and heart rate responses were smaller than in the control state. The unanesthetized dog regulates mean arterial pressure at a higher-than-normal pressure after aortic baroreceptor denervation. Reflexes from the aortic baroreceptors continuously participate in the normal control of mean arterial pressure. Section of the cervical aortic nerves only partially denervates aortic baroreceptors. Our findings may be relevant to human essential hypertension.
Dietary exposure to PCBs and dioxins.
Authors: J S LaKind, J G Filser
Journal: Environmental Health Perspectives (1999)

comments on S. Patandin et al. : Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood: a comparison between breast-feeding, toddler, and long-term exposure. Environ Health Perspect 107:45-51 (1999).
Points from Letters: New Code for Drugs
Authors: G. P. Deutsch
Journal: BMJ (1964)

feather-bedded " with tax allowances and incentives the struggles of the G.P.s to improve their existing surgeries or build new ones with discouragement at every turn is one of the iniquities of the present day.Now that we are no longer members of a "fee-raising " profession, if our masters call the tune they must pay the piper in full.
Editorial: Value of fluoride supplements in prevention of dental caries
Authors: F. J. Margolis
Journal: JAMA (1975)

Dental caries is the most common disease of mankind. Numerous studies over the years have demonstrated the significant effects of water fluoridation in reducing caries. Methods are now finally available whereby caries rates can be remarkably reduced for those children living in nonfluoridated water areas. In the July issue of the<i>American Journal of Diseases of Children</i>(129:794-800, 1975), an article by Margolis et al, "Fluoride: Ten-Year Prospective Study of Deciduous and Permanent Dentition," reports a striking reduction in caries rates with the use of supplemental fluoride treatment prescribed from infancy. The responsibility for giving lifetime protection to the deciduous and permanent teeth lies of necessity with the physician. Since the deciduous teeth are calcified by age 1, and calcification of the permanent teeth begins at birth and is complete at age 8 to 10 years, supplemental fluoride must be prescribed in the first ten months of life and continued
Correlative studies of a Phase II clinical study of bavituximab and sorafenib in patients with advanced hepatocellular carcinoma
Authors: Adam Yopp, Nikoletta Kallinteris, Xianming Huang, Joe Shan, Kerstin Menander, Jeff Hutchins, Steve King, Xiaowei Xu, Dmitry Gabrilovich, Rolf Brekken
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Hepatocellular carcinoma (HCC) is the third leading cause of cancer worldwide. The incidence and mortality of HCC have increased three-fold in the United States over the past few years and the majority of patients present with advanced disease. Bavituximab is a novel chimeric IgG1
Triglyceride-Rich Lipoproteins Prime Aortic Endothelium for an Enhanced Inflammatory Response to Tumor Necrosis Factor-α
Authors: Harold J. Ting, James P. Stice, Ulrich Y. Schaff, David Y. Hui, John C. Rutledge, Anne A. Knowlton, Anthony G. Passerini, Scott I. Simon
Journal: Circulation Research (2007)

High levels of triglyceride-rich lipoproteins (TGRLs) in blood are linked to development of atherosclerosis, yet the mechanisms by which these particles initiate inflammation of endothelium are unknown. TGRL isolated from human plasma during the postprandial state was examined for its capacity to bind to cultured human aortic endothelial cells (HAECs) and alter the acute inflammatory response to tumor necrosis factor-alpha. HAECs were repetitively incubated with dietary levels of freshly isolated TGRL for 2 hours per day for 1 to 3 days to mimic postprandial lipidemia. TGRL induced membrane upregulation of the low-density lipoprotein family receptors LRP and LR11, which was inhibited by the low-density lipoprotein receptor-associated protein-1. TGRLs alone did not elicit inflammation in HAECs but enhanced the inflammatory response via a 10-fold increase in sensitivity to cytokine stimulation. This was reflected by increased mitogen-activated protein kinase activation, nuclear translocation of NF-kappaB, amplified expression of endothelial selectin and VCAM-1, and a subsequent increase in monocyte-specific recruitment under shear flow as quantified in a microfabricated vascular mimetic device.
Number of UK patients awaiting a transplant reaches record high
Authors: Roger Dobson
Journal: BMJ (2007)

The government has admitted that it will have to wait years before it discovers whether there are real productivity gains from the new consultants' contract.NHS leaders also told the House of Commons Committee of Public Accounts last week that lessons had been learnt from mistakes made when the contract was introduced, such as not piloting it before implementation.They were giving evidence as part of the committee's inquiry into the consultants' contract.The session was prompted by the publication earlier this month of a report from the government's
Hospital readmission performance and patterns of readmission: retrospective cohort study of Medicare admissions
Authors: K. Dharmarajan, A. F. Hsieh, Z. Lin, H. Bueno, J. S. Ross, L. I. Horwitz, J. A. Barreto-Filho, N. Kim, L. G. Suter, S. M. Bernheim, E. E. Drye, H. M. Krumholz
Journal: BMJ (2013)

<b>Objectives</b> To determine whether high performing hospitals with low 30 day risk standardized readmission rates have a lower proportion of readmissions from specific diagnoses and time periods after admission or instead have a similar distribution of readmission diagnoses and timing to lower performing institutions. <b>Design </b>Retrospective cohort study. <b>Setting</b> Medicare beneficiaries in the United States. <b>Participants</b> Patients aged 65 and older who were readmitted within 30 days after hospital admission for heart failure, acute myocardial infarction, or pneumonia in 2007-09. <b>Main outcome measures</b> Readmission diagnoses were classified with a modified version of the Centers for Medicare and Medicaid Services' condition categories, and readmission timing was classified by day (0-30) after hospital discharge. Hospital 30 day risk standardized readmission rates over the three years of study were calculated with public reporting methods of the US federal government, and hospitals were categorized with bootstrap analysis as having high, average, or low readmission performance for each index condition. High and low performing hospitals had ≥95% probability of having an interval estimate respectively less than or greater than the national 30 day readmission rate over the three year period of study. All remaining hospitals were considered average performers. <b>Results</b> For readmissions in the 30 days after the index admission, there were 320 003 after 1 291 211 admissions for heart failure (4041 hospitals), 102 536 after 517 827 admissions for acute myocardial infarction (2378 hospitals), and 208 438 after 1 135 932 admissions for pneumonia (4283 hospitals). The distribution of readmissions by diagnosis was similar across categories of hospital performance for all three conditions. High performing hospitals had fewer readmissions for all common diagnoses. Median time to readmission was similar by hospital performance for heart failure and acute myocardial infarction, though was 1.4 days longer among high versus low performing hospitals for pneumonia (P&lt;0.001). Findings were unchanged after adjustment for other hospital characteristics potentially associated with readmission patterns. <b>Conclusions</b> High performing hospitals have proportionately fewer 30 day readmissions without differences in readmission diagnoses and timing, suggesting the possible benefit of strategies that lower risk of readmission globally rather than for specific diagnoses or time periods after hospital stay.
Characterization of two novel cell lines, DERL-2 (CD56+/CD3+/TCRγδ+) and DERL-7 (CD56+/CD3−/TCRγδ−), derived from a single patient with CD56+ non-Hodgkin's lymphoma
Authors: R Di Noto, F Pane, A Camera, L Luciano, M Barone, C Lo Pardo, P Boccuni, M Intrieri, B Izzo, MR Villa, M Macrí, B Rotoli, L Sacchetti, F Salvatore, L Del Vecchio
Journal: Leukemia (2001)