tbuckley/cabot-search huggingface dataset:
Heart Block after Repair of Ventricular Septal Defect in Children
Authors: RONALD M. LAUER, PATRICK A. ONGLEY, JAMES W. DUSHANE, JOHN W. KIRKLIN
Journal: Circulation (1960)

From March 1955 to April 1959, 174 patients with ventricular septal defect and 124 patients with ventricular septal defect associated with pulmonic stenosis were referred from the Section of Pediatrics of the Mayo Clinic for open intracardiac repair. Forty-eight of these 298 patients had complete heart block at some time following operation. Eighteen of the patients with heart block died in the immediate postoperative period, 18 had reversion to normal sinus rhythm, and 12 were discharged from the hospital with complete heart block. Three of these 12 patients died subsequently. Two died presumably as a direct result of complete heart block and a third died following a second open cardiac operation. Of the 9 surviving patients, 3 have had serious bradycardia or periods of asystole and 6 have no symptoms from heart block. One of 3 surgical technics was employed for all the patients in this study with variation in incidence of block with the use of each technic. Other factors that might relate to the incidence of heart block are discussed. The management of the patient with complete heart block both in the immediate post-operative period and after dismissal from the hospital is described.
Bcl-2 Inhibition of Autophagy: A New Route to Cancer?
Authors: Sophie Pattingre, Beth Levine
Journal: Cancer Research (2006)

Abstract Bcl-2 was the first identified cellular protein that functions as an oncogene by blocking apoptotic cell death. Beclin 1, the first identified mammalian autophagy gene product, is a haploinsufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein. We recently showed that Bcl-2 negatively regulates Beclin 1-dependent autophagy and Beclin 1-dependent autophagic cell death. These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy. (Cancer Res 2006; 66(6): 2885-8)
Oxidative capacity of skeletal muscle in heart failure patients versus sedentary or active control subjects
Authors: Bertrand Mettauer, Joffrey Zoll, Hervé Sanchez, Eliane Lampert, Florence Ribera, Vladimir Veksler, Xavier Bigard, Philippe Mateo, Eric Epailly, Jean Lonsdorfer, Renée Ventura-Clapier
Journal: Journal of the American College of Cardiology (2001)
Decline of hepatitis C virus load in serum during the first 24 h after administration of interferon-beta as a predictor of the efficacy of therapy
Authors: Takayoshi Fukutomi, Makoto Nakamuta, Marie Fukutomi, Masataka Iwao, Hironobu Watanabe, Kaichiro Hiroshige, Yuichi Tanabe, Hajime Nawata
Journal: Journal of Hepatology (2001)
Arteriovenous Malformation of the Small Bowel Demonstrated During the Flow Phase of a Meckel??s Scan
Authors: SYDNEY HEYMAN, KEVIN E MCCARTHY
Journal: Clinical Nuclear Medicine (1990)

A 5-week-old girl was evaluated with a Meckel's scan because of failure to thrive and heme-positive stools. The flow phase revealed the presence of an unsuspected arteriovenous malformation of the proximal small bowel but the study was negative for a Meckel's diverticulum. This finding was confirmed by blood pool imaging with Tc-99m red bloodcells. The importance of including theflow phase when performing a Meckel's scan or studies to localize gastrointestinal bleeding is emphasized.
Features of Syndrome X in First-Degree Relatives of NIDDM Patients
Authors: Murray W Stewart, David B Humphriss, Taher S Berrish, Luis A Barriocanal, Laura R Trajano, K George M M Alberti, Mark Walker
Journal: Diabetes Care (1995)

OBJECTIVE To determine whether the features of syndrome × are more common in first-degree relatives of non-insulin-dependent diabetes mellitus (NIDDM) patients than in control subjects with no family history of diabetes. RESEARCH DESIGN AND METHODS A total of 154 first-degree relatives from 60 families with two or more NIDDM patients and 154 age- and sex-matched control subjects were studied. All subjects underwent a 75-g oral glucose tolerance test and baseline lipid blood and anthropometric measures. The features of syndrome × that were studied were obesity, hypertension, dyslipidemia (high triglyceride levels and low high-density lipoprotein [HDL] cholesterol concentrations), impaired glucose tolerance (World Health Organization criteria), and insulin resistance (as assessed by the homeostasis model assessment). RESULTS Relatives were heavier than control subjects (body mass index 27.5 ± 5.2 vs. 25.2 ± 4.6 kg/m2, respectively [mean ± SD], P &amp;lt; 0.0002), had lower HDL cholesterol concentrations (1.2 ± 0.3 vs. 1.4 ± 0.4 mmol/l, P &amp;lt; 0.001), were more insulin-resistant (2.3 [0.7−7.6] vs. 1.6 [0.5−5.1], geometric mean [95% confidence intervals], P &amp;lt; 0.0001), and had more individuals classified as having impaired glucose tolerance (28 of 154 [18%] vs. 7 of 154 [7%], χ 2, P &amp;lt; 0.001). The differences in insulin resistance and HDL cholesterol concentrations between the groups were independent of obesity. CONCLUSIONS Features of syndrome X occur more frequently in relatives of NIDDM patients than in control subjects with no family history of diabetes.
California Authorization of Funds for the Antismoking Campaign-Reply
Authors: Andrew A. Skolnick
Journal: JAMA (1993)

<h3>In Reply.</h3> —My reports were accurate. Dr Coye says I did not mention the program cuts the DHS had to make. In fact, I discussed California's $6 billion deficit in the second column of the first page and quoted Dr Coye's statement that her department had "been forced to eliminate $300 million in medical services." My first article concerned the recent California superior court ruling that Coye's attempted diversion of antitobacco media funds was illegal. According to spokespersons for the ALA of California, the DHS canceled eight of the ALA's 11 grants after the ALA made it clear that it would take Dr Coye, the DHS, and Governor Pete Wilson to court if they went ahead with the diversion. Dr Coye claims here that the ALA endorsed her confirmation. However, Charles Mittman, MD, president of the ALA of California, says this isn't so. Because the ALA was suing Coye and
Differential regulation of gap junctions by proinflammatory mediators in vitro.
Authors: J Hu, I A Cotgreave
Journal: Journal of Clinical Investigation (1997)

The development of inflammation is an important component of host defense against infection. The cellular and molecular processes underlying inflammation are well-studied, and it is known that cells of the blood vessel wall, such as endothelial cells and smooth muscle cells, play pivotal roles. Additionally, a wide variety of proinflammatory mediators have been defined, which coordinate the multicellular processes of inflammation. Knowledge of the potential role of blood vessel gap junctional intercellular communication (GJIC) in coordinating the inflammation process, however, is limited. In this study, we report that bacterial lipopolysaccharide (LPS), as well as the proinflammatory cytokines TNF-alpha and IL-1beta, selectively inhibit human myoendothelial GJIC in vitro without affecting GJIC between the respective homologous cell populations. This finding may represent a physiologically relevant component of the inflammatory response to infection. The work also provides some of the first clear evidence suggesting that a single eukaryotic cell can differentially regulate its GJIC between homologous and heterologous cell types in a simultaneous manner.
David Michael Flanagan
Authors: Julia Flanagan
Journal: BMJ (2006)

​FormerFormer general practitioner Crosby, Liverpool (b 1935; q London 1960), died after heart surgery on 2 June 2006.



Figure 1



David Flanagan followed his father and uncle into their practice in Crosby and Bootle, Merseyside, after being an intern at the King Edward VII Memorial Hospital, Bermuda, during 1961-2. He retired reluctantly in October 2004. He was an examiner at Liverpool University, worked voluntarily as medical officer to a local branch of an international hospice, and to celebrate his 60th birthday worked in primitive conditions to alleviate AIDS suffering in Honduras. He also cared for juvenile drug addicts as chairman of a charitable trust. He leaves a wife, Margaret; two children, two daughters having predeceased him; and 10 grandchildren.
Development of Paper-strip Test for 3-Hydroxybutyrate and its Clinical Application
Authors: Yutaka Harano, Masaaki Suzuki, Hideto Kojima, Atsunori Kashiwagi, Hideki Hidaka, Yukio Shigeta
Journal: Diabetes Care (1984)

A rapid paper-strip test for the semiquantitating 3-hydroxybutyrate (3-OHBA) has been developed. The color develops within 5 min after applying the serum to the paper strip, and the purple color was read either visually or by reflectance meter. This can detect 3-OHBA levels as low as 0.1 mmol/L up to 2.0 mmol/L. The more concentrated sample can be measured on serial dilution. Clinical usefulness has been tested in a summer camp for insulin-dependent diabetic children as well as in a routine diabetes clinic. Serum 3-OHBA levels ranged from &amp;gt; 100 µumol/L to 4 mmol/L in all the subjects before breakfast in a summer camp. In four subjects, 3-OHBA was elevated to the level of 2–4 mmol/L, and only one of these four subjects exhibited ketonuria by nitroprusside test. In a diabetes clinic, a new paper-strip test for 3-OHBA has revealed ketonemia in 34 (74%) of 46 diabetic subjects, while nitro-prusside test revealed ketonemia in only 4 (13%). The present paper-strip test for 3-OHBA is sensitive enough to detect levels as low as 0.1 mmol/L and is clinically useful for rapid detection of ketosis proneness as well as for monitoring of diabetes control.
THE BLOOD IN LOBAR PNEUMONIAWITH REMARKS CONCERNING TREATMENT.
Authors: EDWARD C. ROSENOW
Journal: JAMA (1905)

Her physician, Dr. Thomas of Decatur, suspected either ap¬ pendicitis or an ovarian tumor with torsion of the pedicle.Present Condition.-Wellnourished, good color, pulse 120 a minute and of fair volume.Temperature, 100.2 F. Abdo¬ men as large as that of a woman at or near term, and regu¬ lar in contour.Physical Examination.-Thiswas quite unsatisfactory on account of extreme abdominal tenderness, which is general.However, a fluctuating tumor can be made out and the uterus seems large and has a soft cervix.There is no localized ab¬ dominal rigidity.Diagnosis.-Pregnancy,complicated with ovarian cyst with torsion of the pedicle and consequent peritonitis.Immediate operation advised and accepted.You are fortunate, gentlemen, in having the oppor¬ tunity to see this case, because of the fact that they arc not of very frequent occurrence and for the additional reason that they are, in a measure, emergency cases and therefore not often presented for clinical demon¬ stration.The case, too, is quite typical of its kind and
Rollout of health insurance exchanges is behind schedule
Authors: M. McCarthy
Journal: BMJ (2013)

Health insurance exchanges, a key element of the 2010 Affordable Care Act, may not be ready by their 1 October deadline, conclude two reports from the Government Accountability Office, an investigative agency of the US Congress.

The reports were requested by Congressional Republicans who oppose implementation of the act.

The exchanges were supposed to serve as “one stop shops” where consumers could not only compare competing health insurance plans side by side but also learn whether they qualified for income based subsidies to help them purchase coverage and whether they were eligible for other coverage, such as that offered free through Medicaid to people on low incomes. …
The pili of Aeromonas hydrophila: identification of an environmentally regulated "mini pilin".
Authors: A S Ho, T A Mietzner, A J Smith, G K Schoolnik
Journal: The Journal of Experimental Medicine (1990)

Ultrastructural studies of Aeromonas hydrophila strain AH26 revealed two distinctive pilus types: "straight" pili appear as brittle, rod-like filaments, whereas "flexible" pili are supple and curvilinear. Straight pili are produced constitutively under all tested conditions of growth. In contrast, the expression of flexible pili is regulated by physical and chemical variables, being produced at 22 vs. 37 degrees C, in a liquid vs. a solid medium, and when the availability of free-iron is reduced by the presence of deferoxamine mesylate. Both pilus proteins were purified and biochemically and functionally characterized. The major repeating subunit of the straight pilus is a 17,000-mol wt polypeptide with amino acid sequence homology with Escherichia coli type 1 and Pap pili. The flexible pilus filament is a homopolymer composed of a novel 46 amino acid polypeptide. Resistance of the flexible pilus filament to disaggregation using various chemical treatments was demonstrated; its stability as a polymer and its apparent mechanical strength seem to be conferred by a 20 amino acid hydrophobic, COOH-terminal domain. Purified straight pili lack hemagglutinating function. In contrast, purified flexible pili cause the agglutinin of human, guinea pig, ovine, bovine, and avian erythrocytes, although this property could only be demonstrated in the presence of divalent cations and was most evident at 4 vs. 22 degrees C. Taken together, these results suggest that the pathogenic and ecological roles of the flexible pilus are related to this species' existence as a free-living organism in aquatic environments and its ability to cause infections, both in cold-blooded vertebrates and the human intestine.
Foetus and Placenta
Authors: Robert H. Davis
Journal: JAMA (1970)

Recognized authorities, mainly from Europe, present an important survey on the fetus and placenta as a functional unit. Few areas of medical research offer a better opportunity for cooperation between anatomists, biochemists, pathologists, endocrinologists, pediatricians, and obstetricians. Effective writing and expert editing integrate more than 2,000 references into a synoptic view of current thinking on human pregnancy. Each review appraises yesterday's achievements with a sharp eye on tomorrow's possible discoveries, while many fruitful hypotheses invite experimental verification. Ignorance about the dynamic relationships between the uterus, placenta, and fetus constitutes a poor background for solving obstetrical problems. The reader receives a broad panorama of evidence for evaluating both sides of critical questions as well as a philosophy behind an experimental approach. Topics include: placental morphology, pathology, enzymology, transfer, and assessment of function; growth and vasculature of the conceptus; steroid and protein hormones of pregnancy; fetal endocrinology. The solution to many problems
New Twist in Knee Repair
Authors: Michael Fitzpatrick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New challenges for humanitarian protection
Authors: C Bruderlein, J Leaning
Journal: BMJ (1999)

<h3>Abstract</h3> The circumstances of homelessness create the potential for rapid transmission of SARS-CoV-2 in this vulnerable population. Upon observing a cluster of COVID-19 cases from a single large homeless shelter in Boston, Boston Health Care for the Homeless Program conducted symptom assessments and polymerase chain reaction (PCR) testing for SARS-CoV-2 among all guests residing at the shelter over a 2-day period. Of 408 participants, 147 (36.0%) were PCR-positive for SARS-CoV-2. COVID-positive individuals were more likely to be male (p&lt;0.001) but did not differ significantly from COVID-negative individuals with respect to other demographic and clinical characteristics. Cough (7.5%), shortness of breath (1.4%), and fever (0.7%) were all uncommon among COVID-positive individuals. Our findings illustrate the rapidity with which COVID-19 can be widely transmitted in a homeless shelter setting and suggest that universal PCR testing, rather than a symptom triggered approach, may be a better strategy for identifying and mitigating COVID-19 among people experiencing homelessness.
Renal Disease in Childhood
Authors: Malcolm A. Holliday
Journal: JAMA (1969)

This book reflects the coming of age of pediatric nephrology, as separate from the not-so-old specialty of nephrology. The text, intended as a "concise practical guide for pediatricians, urologists, general practitioners, and residents," fulfills its purpose well, in a restricted sense. The opening section on anatomy is well written, and the diagrams are satisfactory (although I prefer actual specimens to diagrams). The section concerned with function is given in places to mechanical explanations that suffer from oversimplifying a dynamic phenomenon. Before taking up specific renal disorders, the author describes their symptoms, signs, and laboratory tests. The treatment is quite conventional, but I believe useful to his chosen audience. Here and there I disagree, eg, a fundoscopic examination in patients with renal disease often is helpful well before exudates develop. A poor correlation between specific gravity and osmolality all but cancels the usefulness of specific gravity, except as a qualitative indicator
LEPROSY IN SAN FRANCISCO.Read in the Section on Practice of Medicine at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: DOUGLASS W. MONTGOMERY
Journal: JAMA (1894)

In all ages and in all countries the mass of mankind has believed in the contagiousness of leprosy, and even now, when exposed to the sharpened criticism of scientific inquiry, contagion is still the only basis on which we can explain the facts. It is not known how the contagium is carried or how inoculated. We do not know what manifestation it makes at the seat of inoculation, or whether it makes any capable of being clinically appreciated. It is not understood why one person may become infected from what seems a short exposure, while another nay dwell most intimately and for long stretches of time with lepers, and never contract the disease. We are not in a position to explain these nor a host nf other facts, but we do know that when we find a leper, we immediately inquire for other lepers with whom he has been in
Cd2 Sets Quantitative Thresholds in T Cell Activation
Authors: Martin F. Bachmann, Marijke Barner, Manfred Kopf
Journal: The Journal of Experimental Medicine (1999)

It has been proposed that CD2, which is highly expressed on T cells, serves to enhance T cell–antigen presenting cell (APC) adhesion and costimulate T cell activation. Here we analyzed the role of CD2 using CD2-deficient mice crossed with transgenic mice expressing a T cell receptor specific for lymphocytic choriomeningitis virus (LCMV)-derived peptide p33. We found that absence of CD2 on T cells shifted the p33-specific dose–response curve in vitro by a factor of 3–10. In comparison, stimulation of T cells in the absence of lymphocyte function–associated antigen (LFA)-1–intercellular adhesion molecule (ICAM)-1 interaction shifted the dose–response curve by a factor of 10, whereas absence of both CD2–CD48 and LFA-1–ICAM-1 interactions shifted the response by a factor of ∼100. This indicates that CD2 and LFA-1 facilitate T cell activation additively. T cell activation at low antigen density was blocked at its very first steps, as T cell APC conjugate formation, TCR triggering, and Ca2+ fluxes were affected by the absence of CD2. In vivo, LCMV-specific, CD2-deficient T cells proliferated normally upon infection with live virus but responded in a reduced fashion upon cross-priming. Thus, CD2 sets quantitative thresholds and fine-tunes T cell activation both in vitro and in vivo.
Ratio of IgE Receptor to TLR9 on Human Plasmacytoid Dendritic Cells Predicts Allergic Status and Cytokine Response to Innate and Adaptive Immune Stimuli
Authors: J.R. Tversky, A.P. Bieneman, K.L. Chichester, J.T. Schroeder
Journal: Journal of Allergy and Clinical Immunology (2007)
The AIDS Pandemic: Complacency, Injustice, and Unfulfilled Expectations
Authors: P. A. Selwyn
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conference urges greater effort to reduce human threat from avian influenza
Authors: Jane Parry
Journal: BMJ (2007)

Much remains to be done in the international fight against the human threat from avian influenza, said Dr David Nabarro, the UN system senior coordinator for avian and human influenza. “The glass is still half empty in terms of international efforts,” he said, speaking at the fourth international bird flu summit in Washington, DC, last week.

The conference covered a wide range of issues related to avian …
THE URINARY EXCRETION OF ANDROGENIC AND ESTROGENIC SUBSTANCES IN CERTAIN ENDOCRINE STATES. STUDIES IN HYPOGONADISM, GYNECOMASTIA AND VIRILISM 1
Authors: A. T. Kenyon, T. F. Gallagher, D. H. Peterson, R. I. Dorfman, F. C. Koch
Journal: Journal of Clinical Investigation (1937)