Relationship of Hydroxyproline Excretion in Urine to Collagen Metabolism
Authors: DARWIN J. PROCKOP
Journal: Annals of Internal Medicine (1967)

Review1 June 1967Relationship of Hydroxyproline Excretion in Urine to Collagen MetabolismBiochemistry and Clinical ApplicationsDARWIN J. PROCKOP, M.D., PH.D., KARI I. KIVIRIKKO, M.D.DARWIN J. PROCKOP, M.D., PH.D.Search for more papers by this author, KARI I. KIVIRIKKO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-6-1243 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEssentially all the hydroxyproline in the tissues of vertebrates is found in collagen, and, except for the small amount of hydroxyproline in elastin, no other animal protein contains significant amounts of this amino acid (1). As has been recognized for over a decade, the relatively unique distribution of hydroxyproline among proteins makes this amino acid a useful, naturally occurring label for studying the metabolism of collagen. 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