tbuckley/cabot-search huggingface dataset:
Canadian court hears arguments on physician assisted suicide for severely ill patients
Authors: O. Dyer
Journal: BMJ (2014)

Canada’s Supreme Court this week heard arguments in a case that will decide the legality of physician assisted suicide for severely ill people, amid signs that government lawyers face an uphill fight in persuading justices of the benefits of the current law, under which doctors’ assistance in dying is a crime equivalent to manslaughter.

The constitutional challenge was brought by the children of Kathleen Carter, who had to travel to Switzerland at age 89 to end her life, and resembles a landmark 1993 case in which the court ruled 5-4 against legalising the practice. But the current hearing takes place in a much transformed political landscape.

A week before the case opened, an Ipsos …
"Responsibility deal" is unlikely to produce health benefits, says report
Authors: S. Ginn
Journal: BMJ (2011)

The government’s public health “responsibility deal” is an “irresponsible” and “inadequate” response to England’s public health problems, says a new report.

The responsibility deal is at the centre of the coalition government’s health strategy. It involves partnerships between public health, commercial, and voluntary organisations to improve public health without legislation ( BMJ 2011;342:d1702, doi:10.1136/bmj.d1702).

The report, from the Children’s Food Campaign, which works to improve the health of young people, criticises the deal’s pledges aimed at the food industry.

“The responsibility deal’s pledges are minor, and even these have not been universally adopted,” says a report coauthor, Charlie Powell, campaign …
MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice.
Authors: E H Leiter, G J Christianson, D V Serreze, A T Ting, S M Worthen
Journal: The Journal of Experimental Medicine (1989)

This study provides a basis for understanding the wide variations reported in the literature in IFN-gamma inducibility of class II MHC antigens on murine beta cells. Inducibility is not an intrinsic property of all mouse beta cells, but instead depends upon strain- (and tissue-) specific response modifying factors. This was demonstrated by comparison of constitutive and IFN-gamma-induced class I and class II MHC gene products on cultured islet cell monolayers. Islet cultures were established from autoimmune diabetes-prone NOD/Lt mice, diabetes-resistant NON/Lt and CBA/J mice, as well as F1 hybrids between these latter two strains and NOD/Lt. Cultures of peritoneal macrophages (M phi) from each strain were established as controls. After 3 wk of culture (with incubation in the presence or absence of IFN-gamma during the last 6 d), constitutive expression as well as IFN-gamma induction of class I MHC antigen expression was demonstrated on NOD/Lt and NON/Lt islet cells by antibody plus complement-mediated cytotoxicity. Although CBA/J islets and M phi did not maintain constitutive class I or class II antigen expression in culture in the absence of IFN-gamma, class I H-2Kk antigen was IFN-gamma inducible. Whereas IFN-gamma-induced class II I-Ak antigen on CBA/J M phi, it failed to induce this antigen on CBA/J islets. In contrast, I-A antigens were IFN-gamma inducible on NOD/Lt and NON/Lt islets and M phi. In (CBA x NOD)F1 hybrids, loss of IFN-gamma inducibility of the I-ANOD product established that suppression was mediated by a trans-acting factor from the CBA/J genome. In the course of these studies, IFN-gamma inducibility of a crossreactive occult class I-like antigen on both NOD/Lt islet cell and M phi cultures was unexpectedly detected when mAb 28-13-3 (public specificity 39, reactive with H-2Kb,f) was used as a negative control. Although not detectable by cytofluorographic analysis of freshly isolated NOD/Lt splenic leukocytes, occult antigen could be induced on NOD/Lt peritoneal macrophages (M phi) cultured for 3 d in IFN-gamma. Time course of induction showed the occult antigen to be distinct from NOD/Lt class I and II gene products. In both islet cell and M phi cultures established from (CBA x NOD)F1 hybrids, trans-suppressive factor(s) from the CBA/J genome not only suppressed IFN-gamma-induced expression of I-ANOD, but additionally suppressed occult antigen induction. Backcross of F1 to both parental strains indicated that the occult locus was on Chr 17, tightly linked to MHC.(ABSTRACT TRUNCATED AT 400 WORDS)
Successful anti‐CD20 monoclonal antibody treatment of severe autoimmune hemolytic anemia due to warm reactive IgM autoantibody in a child with common variable immunodeficiency
Authors: Mary Wakim, Ami Shah, Patricia A. Arndt, George Garratty, Kenneth Weinberg, Thomas Hofstra, Joseph Church
Journal: American Journal of Hematology (2004)

Abstract Autoimmune hemolytic anemia due to warm reactive IgM autoantibodies is unusual, severe, and often fails to respond to standard immunosuppressive therapies in both adults and children. A 6‐year‐old girl with common variable immunodeficiency had longstanding steroid dependent, splenectomy‐unresponsive, warm IgM autoantibody‐mediated autoimmune hemolytic anemia. Rituximab, a monoclonal antibody directed against CD20 antigen, was used to deplete B lymphocytes and reduce autoantibody production. She received a total of six doses of rituximab (375 mg/m 2 ). Therapy was well tolerated, and B‐lymphocytes were effectively depleted from the peripheral blood. The patient was completely tapered off glucocorticoids. The patient has remained off immunosuppressive agents for 16 months despite the return of B lymphocytes to the peripheral circulation. She continues to require IVIG. Early treatment with rituximab might be an option for patients with warm reactive IgM autoantibody‐mediated autoimmune hemolytic anemia not responding to other treatments or experiencing untoward side effects from those treatments. Am. J. Hematol. 76:152–155, 2004. © 2004 Wiley‐Liss, Inc.
SURVIVAL OF VACCINE VIRUS SEPARATED FROM LIVING HOST CELLS BY COLLODION MEMBRANES
Authors: R. S. Muckenfuss, T. M. Rivers
Journal: The Journal of Experimental Medicine (1930)

Vaccine virus, suspended in a mixture of serum and Tyrode's solution and separated by collodion membranes from a suspension of living kidney cells in serum and Tyrode's solution, remained active at 37°C. for a longer period of time than did vaccine virus incubated only in a mixture of serum and Tyrode solution.
Unresectable Cholangiocarcinoma: Comparison of Survival in Biliary Stenting Alone Versus Stenting With Photodynamic Therapy
Authors: Michel Kahaleh, Rajnish Mishra, Vanessa M. Shami, Patrick G. Northup, Carl L. Berg, Penny Bashlor, Petra Jones, Kristi Ellen, Geoffrey R. Weiss, Christiana M. Brenin, Barbara E. Kurth, Tyvin A. Rich, Reid B. Adams, Paul Yeaton
Journal: Clinical Gastroenterology and Hepatology (2008)
Seborrhoeic dermatitis of the scalp—a manifestation of Hailey–Hailey disease in a predisposed individual?
Authors: P. MARREN, S. BURGE
Journal: British Journal of Dermatology (1992)

A 59-year-old man was found to have typical Hailey–Hailey disease of the back, neck and axillae. In addition, he had fine white scaling in the scalp and postanricular areas. Despite the clinical appearance of seborrhoeic dermatitis, a biopsy of his scalp showed prominent suprabasal epidermal separation with acantholysis. We propose that in a genetically predisposed individual. Hailey–Hailey disease can assume atypical and non-specific appearances.
Physiology and biochemistry of endothelial function in children with chronic renal failure
Authors: Jameela A. Kari, Ann E. Donald, David T. Vallance, K.R. Bruckdorfer, Anna Leone, Michael J. Mullen, Timothy Bunce, Belen Dorado, John E. Deanfield, Lesley Rees
Journal: Kidney International (1997)
Rupture of the Thoracic Aorta: Complication of Resuscitation
Authors: Robert H. Patterson
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Since the advent of external cardiac massage in 1960<sup>1</sup>various complications have been reported, some of which are life-threatening or incompatible with survival, even if the event leading to cardiac arrest is reversible. Nelson and Ashley in 1965 reported the only heretofore published case of aortic rupture attributable to external cardiac massage.<sup>2</sup>We wish to report two similar cases recently seen—one at The George Washington University Hospital Medical Center and the other at the Washington DC Veterans Administration Hospital. <h3>Report of Cases.—Case 1.—</h3> A 70-year-old man had a cardiac arrest several hours after the onset of severe chest pain. Defibrillation and external cardiac massage were unsuccessful. Necropsy disclosed eight fractures of the right ribs, a 1,500-ml hemothorax on the left, and a 1-cm tear of the anterior proximal descending aorta, which had large, complicated, atheromatous plaques but no aneurysm. The aorta had some
99mTc-Methylene Diphosphonate Imaging in Neural Crest Tumors
Authors: J R STY, D P BABBITT, J T CASPER, R A BOEDECKER
Journal: Clinical Nuclear Medicine (1979)

Thirteen patients with neural crest tumors were each studied with a radionuclide skeletal survey, a radiographic skeletal survey, and an iliac crest bone marrow aspiration. The RN skeletal survey proved to be more accurate than the radiographic skeletal survey in: 1) detecting the primary tumor; 2) demonstrating bony metastatic disease; and 3) evaluating response to therapy. The overall accuracy of the RN skeletal survey in detecting metastatic disease correlated with the results of bone marrow aspiration both in the initial detection of metastatic disease and the evaluation of response during therapy.
Metallic elements in fossil fuel combustion products: amounts and form of emissions and evaluation of carcinogenicity and mutagenicity.
Authors: V B Vouk, W T Piver
Journal: Environmental Health Perspectives (1983)

Metallic elements contained in coal, oil and gasoline are mobilized by combustion processes and may be emitted into the atmosphere, mainly as components of submicron particles. The information about the amounts, composition and form of metal compounds is reviewed for some fuels and combustion processes. Since metal compounds are always contained in urban air pollutants, they have to be considered whenever an evaluation of biological impact of air pollutants is made. The value of currently used bioassays for the evaluation of the role of trace metal compounds, either as major biologically active components or as modifiers of biological effects of organic compounds is assessed. The whole animal bioassays for carcinogenicity do not seem to be an appropriate approach. They are costly, time-consuming and not easily amenable to the testing of complex mixtures. Some problems related to the application and interpretation of short-term bioassays are considered, and the usefulness of such bioassays for the evaluation of trace metal components contained in complex air pollution mixtures is examined.
Let's talk about dying
Authors: M. Lakhani
Journal: BMJ (2011)

Imagine a situation where most people with a common condition do not have it diagnosed. Where opportunities are repeatedly missed to identify the problem and to offer structured evidence based care. Where people are too often denied a chance to influence their care in a planned proactive way. This area of healthcare generates 54% of all hospital complaints.

What is this condition? Dying. Despite huge advances and successes in end of life care in the United Kingdom, of which we should be rightly proud, we have not yet managed to transform care. Someone in Britain dies every minute, yet many of us are afraid to discuss dying, leaving many people unprepared and unable to plan. All of us must do more to talk about this if we are to give patients the best chance of a good death.

Even people with advanced progressive illness who are admitted to hospital are often not identified for end of life care, meaning that many patients who could benefit from palliative care never have that opportunity. Too many people still die in distress with uncontrolled symptoms, are inappropriately …
Characterization and expression analysis of the hair keratin associated protein KAP26.1
Authors: M.A. Rogers, L. Langbein, S. Praetzel-Wunder, K. Giehl
Journal: British Journal of Dermatology (2008)

Background Human hair follicle keratin‐associated proteins (KAPs) comprise a large multigene family of proteins thought to be responsible for the bundling of keratin intermediate filaments. Recently, four new KAP family members KAP24.1, KAP25.1, KAP26.1 and KAP27.1 were identified from the genome, but the expression of only one, KAP24.1, was investigated and shown in hair follicles. Objectives In the current study, the expression of the remaining members of the family were analysed. Methods Reverse transcriptase‐polymerase chain reaction analysis of samples from numerous human organs was used. Results Only KAP26.1 showed expression, which was limited to the hair follicle. By in situ hybridization and immunohistochemistry using a specific antiserum, KAP26.1 was localized to the differentiated portion of the hair cuticle. Conclusions As well as KAP24.1 in hair follicles, expression of KAP26.1 was shown and is found in the differentiated part of the hair cuticle.
Surgically Created Arteriovenous Fistula to Augment the Cephalic Vein: Use as an Arterial Bypass Graft
Authors: Robert L. Beals
Journal: New England Journal of Medicine (1971)

AUTOGENOUS vein grafts are widely accepted as the most satisfactory material for bypassing arterial occlusive disease in the femoropopliteal segment. If the patient does not have a suitable greater saphenous vein because of small diameter, previous stripping or prior use as a bypass graft, the surgeon is hard pressed to find an acceptable substitute.Use of the cephalic vein as a peripheral vascular graft has been proposed by Kakkar.1 The cephalic veins that he studied were found to be of adequate length, diameter and tensile strength to be used as arterial substitutes in the leg.In conjunction with a hemodialysis . . .
Autoimmune Disease, Thyroiditis, and Hyperthyroidism Without Goiter
Authors: Steven G. Dorfman, Robert L. Young, Robert L. Peake
Journal: Annals of Internal Medicine (1977)

Comments1 June 1977Autoimmune Disease, Thyroiditis, and Hyperthyroidism Without GoiterSTEVEN G. DORFMAN, M.D., ROBERT L. YOUNG, M.D., F.A.C.P., ROBERT L. PEAKE, M.D., F.A.C.P.STEVEN G. DORFMAN, M.D.Search for more papers by this author, ROBERT L. YOUNG, M.D., F.A.C.P.Search for more papers by this author, ROBERT L. PEAKE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-6-824 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We previously described eight patients with a syndrome of painless thyroiditis and transient hyperthyroidism without goiter (1). All patients have followed the course of subacute (viral) thyroiditis. Other patients with a similar syndrome of painless thyroiditis and transient hyperthyroidism with goiter have also been described (2-4). All patients with this syndrome have followed the course of subacute thyroiditis but at biopsy have had lymphocytic infiltration compatible with Hashimoto's (autoimmune) thyroiditis.We have followed four of our initial eight patients for 2 or more years (Table 1). The other patients left the local area and were lost to...References1. DORFMANCOOPERMANNELSON SMR: Painless thyroiditis and transient hyperthyroidism without goiter. Ann Intern Med 86:24-28, 1977 LinkGoogle Scholar2. GLUCKNUSYNOWITZPLYMATE FMS: Chronic lymphocytic thyroiditis, thyrotoxicosis, and low radioactive iodine uptake. N Engl J Med 293:624-628, 1975 CrossrefMedlineGoogle Scholar3. GORMANDUICKWOOLNER CDL: A variant of the transient goitrous hyperthyroidism syndrome (abstract). Clin Res 23:515, 1975 Google Scholar4. WOOLFDALY PR: Thyrotoxicosis with painless thyroiditis. Am J Med 60:73-79, 1976 CrossrefMedlineGoogle Scholar5. PEAKEWILLISASIMAKIS RDG: Radioimmunologic assay for antithyroglobulin antibodies. J Lab Clin Med 84:907-919, 1974 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEVEN G. DORFMAN, M.D.; ROBERT L. YOUNG, M.D., F.A.C.P.; ROBERT L. PEAKE, M.D., F.A.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by6 Post-partum hyperthyroidism 1 June 1977Volume 86, Issue 6Page: 824-825KeywordsAutoimmune diseasesBiopsyHyperthyroidismThyroid ePublished: 1 December 2008 Issue Published: 1 June 1977 PDF downloadLoading ...
Elevated Serum Prostate-Specific Antigen Levels in a Woman with Metastatic Breast Cancer
Authors: Eleftherios P. Diamandis
Journal: New England Journal of Medicine (2000)

To the Editor: Prostate-specific antigen (PSA) is a protein produced almost exclusively by the prostate. Although various tissues in females have been found to produce very small amounts of PSA, serum PSA levels in females are quite low and are measurable only with ultrasensitive PSA immunoassays.1 In a study of 1064 women, the highest serum PSA levels were less than 1 μg per liter, and only 1.5 percent of the women had levels that were higher than 0.1 μg per liter; the median value was 0.002 μg per liter.2 Significantly higher values have been reported in women with benign breast . . .
An Analysis Algorithm for Measuring Airway Lumen and Wall Areas from High-Resolution Computed Tomographic Data
Authors: GREGORY G. KING, NESTOR L. MÜLLER, KENNETH P. WHITTALL, QING-SAN XIANG, PETER D. PARÉ
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

High-resolution computed tomography (HRCT) has been used to examine airway narrowing. We developed an automated computed tomographic image analysis algorithm (computed tomographic airway morphometry; CTAM) to measure airway lumen area (Ai ), airway wall area (Awa), and airway angle of orientation. Tubes of varying size were embedded in Styrofoam and then scanned at angles between 0 ° and 50 ° to assess the accuracy of measurements made with CTAM. Two excised pig lungs were fixed in inflation, sectioned, and scanned. Ai and Awa were measured planimetrically from the cut surfaces to optimize CTAM measurement parameters. In CTAM, Ai was defined according to an airway-size–dependent threshold value, and total Awa was determined through a score-guided erosion method. Results were compared with measurements made through a previously validated method (manual method). CTAM provided accurate measurements of the tubes' Ai values at all angles; Awa was overestimated in direct relation to airway size. The manual method underestimated Ai and overestimated Awa in a manner directly related to airway size as well as to airway angle of orientation. In the excised lung, the mean errors of Ai and Awa measurements made with CTAM were 0.52 ± 0.24 mm2 and 0.17 ± 0.32 mm2 (mean ± SEM), respectively. Ai errors with the manual method were similar, but Awa was overestimated to a greater degree (6.3 ± 0.38 mm2; p < 0.01) and the error was proportional to Awa (r = 0.64; p < 0.01). CTAM allows accurate measurements of airway dimensions and angle of orientation. King GG, Müller NL, Whittall KP, Xiang Q-S, Paré PD. An analysis algorithm for measuring airway lumen and wall areas from high-resolution computed tomographic data.
P223 HLA-B*27 IS PROTECTIVE AGAINST HCV GENOTYPE 1 AND 3 AND ASSOCIATED WITH TARGETING OF DISTINCT GENOTYPE-SPECIFIC CD8+ T CELL EPITOPES
Authors: K. Skibbe, B. Budeus, F. Heinemann, L. Timmer, P. Horn, W. van Esch, D. Hoffmann, H. Siemann, N. Scherbaum, J. Timm
Journal: Journal of Hepatology (2014)
What should be done about interval breast cancers?
Authors: S Field, M J Michell, M G W Wallis, A R M Wilson
Journal: BMJ (1995)

The paper by Woodman and colleagues in this week's journal contains the first published data from the NHS breast screening programme on cancers diagnosed in the three years after a negative screen (“interval cancers”) (p 224).1 It reports 15.8 interval cancers per 10000 women screened in the North West region in the 24 months after screening, which is higher than the target that was set for Britain. Preliminary data from 46 screening centres, collected by the National Breast Screening Radiology Quality Assurance Committee, are very similar, suggesting that the North West region is representative of the United Kingdom as a whole.

Comparing rates of interval cancer with those reported in the literature is difficult because different groups have reported the data using different methods and the populations studied have different age compositions. The rates reported today, however, are higher than the rate of 9.4/10000 in the Swedish two county trial2 and are very similar to the rates reported from the Nijmegen (15.7/10000)3 and Stockholm (19.2/10000) trials.4 In Nijmegen in the eight successive screening rounds …
70 LONGITUDINAL ANALYSIS OF PD1 EXPRESSION: IMPACT OF HBEAG SEROCONVERSION DURING ANTIVIRAL TREATMENT OF CHRONIC HEPATITIS B
Authors: A. Evans, A. Riva, H. Cooksley, S. Phillips, A. Nathwani, J. Craigen, S. Brett, S. Chokshi, N. Naoumov
Journal: Journal of Hepatology (2008)
Strengthening the US Health Care Safety Net
Authors: Nicole Lurie
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anesthesia Care for Low-Risk Patients Undergoing Gastrointestinal Endoscopies
Authors: Pascal Scemama, Brian Lee, Emily Guimaraes
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal