tbuckley/cabot-search huggingface dataset:
Disc embolisation after minor strut fracture in a Bjork-Shiley mitral valve prosthesis.
Authors: B Sethia, R O Quin, W H Bain
Journal: Thorax (1983)

We report the successful management of a patient who suffered embolisation of a Bjork-Shiley mitral prosthetic valve disc after fracture of the minor strut.Emergency surgical treatment was responsible for her survival.The disc was recovered through the abdominal aorta at a sub- sequent operation, performed once the condition of the patient had stabilised.This experience confirms previous reports' 2 advocating early reoperation in patients with Bjork-Shiley prostheses who present with acute heart fail- ure and absence of prosthetic valve sounds.We suggest that retrieval of the embolised disc may be carried out separately as an elective procedure provided that there is no evidence of renal or peripheral circulatory impairment. Case reportA 36-year-old woman underwent closed mitral valvotomy
Lumbo-dorsal Sympathectomy in Severe Hypertension
Authors: J. C. Harland, F. d'Abreu
Journal: BMJ (1949)

The treatment of hypertension by resectnon of the dorso- lumbar sympathetic nervous system has been practised for many years in the United States, where there is already an extensive literature on the subject.This literature has been reviewed elsewhere (Blodgett and Cutler, 1947; Bassett, 1948).It is only recently, however, that this treatment has attracted any great interest in this country.It might be helpful, therefore, to review a series of consecutive cases operated on at Westminster Hospital.The number-24 cases-is not large, and any conclusions can be only of a tentative nature.However, all these cases had been fully investigated before operation and have been carefully observed since, and an idea of the value of this form of treatment has begun to emerge.Analysis of Material.-Ofthe 24 patients 15 were men, and of the nine women seven were married and two single.The youngest patient was a girl of 17, and the oldest a man of 60.The average age of the group was 42 years.There was no appreciable difference in age at operation between the men and the women.Six of the patients were over 50.The age incidence in decades was as follows: Under 20 years, I case; 20-29, 2 cases: 30-39, 4 cases; 40-49, 11 cases ; 50-59, 5 cases ; 60 years, I case.Diagnosis In five cases there seemed to be a cause for the hypertension: three patients had chronic nephritis, one patient had calculi in both kidneys, and the fifth, a married woman aged 47, had suffered from eclampsia 28 years previously.One patient with renal hypertension, a man aged 53 who had a clear history of acute nephritis at the age of 23, stated that his father and brother had both died from a " stroke."In this case the chronic nephritis had entered a malignant phase, and the familial tendency to high blood pressure had probably accentuated the disease.In the other 19 cases, in spite of careful interrogation and investigation, the origin of the hypertension was obscure, except that nine had a family history of hypertensive cardiovascular disease, suggesting that they might be cases of essential hypertension.However, when the records of these 19 patients were viewed as a whole an impression was gained that many were cases of chronic renal disease rather than essential hypertension.Malignant Hypertension.-Therewere six cases of malignant hypertension in this series-four primary and two
HIGH SENSITIVITY TROPONIN ASSAY FOR EARLY DIAGNOSIS OF ACUTE CORONARY SYNDROME IN A REAL-WORLD SITUATION: COMPARISON BETWEEN HS-TNT, LOCI HS-TNI, HS-TNI ROCHE AND CONVENTIONAL TNT.
Authors: Gina Biasillo, Luigi M. Biasucci, Roberta Della Bona, Ilaria Dato, Milena Leo, Massimo Gustapane, Maria T. Cardillo, Antonella Stefanelli, Pio Cialdella, Andrea Silenzi, Giulia Pignataro, Niccolò Gentiloni Silveri, Martina Zaninotto, Mario Plebani, Filippo Crea
Journal: Journal of the American College of Cardiology (2010)
Effect of spironolactone on cardiacsympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy
Authors: Shu Kasama, Takuji Toyama, Hisao Kumakura, Yoshiaki Takayama, Shuichi Ichikawa, Tadashi Suzuki, Masahiko Kurabayashi
Journal: Journal of the American College of Cardiology (2003)
Abstract 3876: Cell cycle checkpoint <i>in vivo</i> in developing mouse embryo liver cells
Authors: Kwok Kin Chan, XiaoQi Wang
Journal: Cancer Research (2010)

Abstract Embryonic stem (ES) cells have a distinct cell cycle distribution and cyclins/CDKs expression. ES cells are characterized by a short G1 phase and a high proportion of cell in S and G2 phase, maintain consistent level of cyclins expression seems not to be phase dependent. However, most cell cycle studies are on mouse or human ES cell line, whether that it is really reflective in vivo is not well defined. By extracting fresh liver cells from mouse embryo, we have investigated cell cycle distribution, correspondent cyclins and CDK expression in vivo in mouse embryo from embryonic days 10.5(E10.5, liver start to develop at E9.5) to post-natal 21 days(P21). We found that most of the cells (62%) were in S and G2 phase, 38% of cells in G1 at E11.5. Upon embryo development, the proportion of cells in G1 increased, although there were still large proportion of cells in S and G2 phase (55%) at P0. The short G1 phase in early embryonic day suggests that cell phase distribution may be related with embryo cells’ pluripotency in vivo. Distinct high levels of cyclin D1, E1, A, B1 and CDK1(cdc2) expressed at E10.5, which seemed to be pluripotency related but not cell phase dependent. The cyclins and CDK level started to drop from E11.5 to post-natal (P0) suggesting that cyclins/CDKs expression reduced and became regulated with differentiation. In ES cell line, where G1 population increased with differentiation, G1 DNA-damage checkpoint was still absent. However, in response to ionizing irradiation, P0 mouse liver cells showed a short G2 population increase followed by G1 cell phase arrest indicating that at P0 or even earlier stage, G1 DNA-damage checkpoint had been established in vivo. Thus, cell cycle and cell cycle checkpoint in vivo in mouse embryo liver cells displayed both similar and differential pattern compared to that in mES cell line in vitro. Underlying mechanism such as DNA-damage checkpoint patterns and its regulation will be further discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3876.
Reply to J. Rieger et al
Authors: Elizabeth R. Gerstner, Matthew P. Frosch, Tracy T. Batchelor
Journal: Journal of Clinical Oncology (2010)

We appreciate the comments of Rieger et al. We agree that the mechanism of restricted diffusion remains unclear and may represent different underlying pathophysiologic processes in different patients, considering the heterogeneous nature of gliomas. In our patient, we found infiltrating tumor cells, whereas Rieger et al found evidence of hypoxia in their patient, so there appears to be a spectrum of pathophysiology that accounts for these radiographic changes in patients with glioblastoma who are treated with anti–vascular endothelial growth factor agents. The duration of treatment with bevacizumab and the different chemotherapy agents that have been combined with bevacizumab might influence the underlying pathology as well. More histopathologic correlative studies need to be done to elucidate the underlying changes associated with radiographic findings. There is a critical need to correlate neuro-imaging techniques that measure water diffusion, vascular permeability, tumor perfusion, and metabolism with histology to distinguish patients who are responding to antiangiogenic therapy from patients who may be experiencing disease relapse through tumor infiltration or other mechanisms. Elizabeth R. Gerstner, Matthew P. Frosch, and Tracy T. Batchelor Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA
Immunomagnetic Enrichment and Detection of Micrometastases in Colorectal Cancer: Correlation With Established Clinical Parameters
Authors: Martin R. Weihrauch, Edmund Skibowski, Thomas C. Koslowsky, Wilfried Voiss, Daniel Re, Ferdinand Kuhn-Regnier, Carolin Bannwarth, Michel Siedek, Volker Diehl, Heribert Bohlen
Journal: Journal of Clinical Oncology (2002)

Micrometastatic disease in bone marrow is of prognostic significance in colorectal cancer patients. However, detection rates of standard immunocytology are relatively low. We used magnetic activated cell sorting (MACS), a highly sensitive method, to increase detection rates and correlated the presence of cytokeratin (CK)-expressing cells with clinical parameters.Bone marrow was obtained from 51 consecutive patients with newly diagnosed colorectal adenocarcinoma who underwent primary surgery and 18 control subjects. International Union Against Cancer (UICC) stage I disease was diagnosed in 11 patients, stage II disease was diagnosed in 14 patients, stage III disease was diagnosed in 12 patients, and stage IV disease was diagnosed in 14 patients. CK-positive cells were enriched and stained with magnetically labeled CAM 5.2 antibodies directed to CK 7 and 8.CK-positive cells were found in 33 (65%) patients and were absent in 18 (35%). Four of 11 (36%) patients with UICC stage I disease, nine of 14 (64%) with stage II diease, eight of 12 (67%) with stage III disease, and 12 of 14 (86%) with stage IV disease were CK-positive. Epithelial cells were more frequently found in pT3/4 (72%) than in pT1/2 (36%) tumors (P =.026), but there was no difference for lymph node status. CK-positive patients had a higher chance for elevated carcinoembryonic antigen (85% v 15%, P = NS) and CA 19-9 levels (92% v 8%, P =.019). There were no significant differences in CA 72-4, sex, age, tumor grading, or tumor localization regarding the presence of CK-positive cells. All control subjects were CK-negative.In searching for micrometastases in colorectal cancer patients, we have achieved high detection rates by using MACS. The presence of these cells correlated significantly with tumor stage, tumor extension, and the tumor marker CA 19-9.
Phenothiazine Intoxication in Children
Authors: Joe D. Corless
Journal: JAMA (1965)

THE NEUROLOGICAL syndromes due to phenothiazines, consisting of dystonia, akathisia, and a parkinsonian state, have been frequently described.<sup>1-4</sup>Symptoms of phenothiazine toxicity are known to be more marked in infants and young adults, and they also occur with more frequency in patients in a toxic condition and in dehydrated and febrile patients.<sup>3</sup>There is little mention in the literature of reactions which produce spasticity and pathological reflexes. One such case, reported by Swaiman,<sup>5</sup>concerns a widely used and relatively safe phenothiazine, promethazine hydrochloride, which caused marked central-nervous-system depression, hyperreflexia and Babinski's sign on both sides in a dehydrated child. We have seen similar patients whom we feel developed such neurological symptoms and signs as a result of a reaction to phenothiazines. <h3>Report of Cases</h3><h3>Case 1.—</h3> An 8-year-old white boy was admitted because of two days of lethargy, anorexia, and vomiting, and several hours of irrational behavior,
Atrial Tachysystole (Flutter?) with Apparent Exit Block
Authors: ROGER P. JAVIER, ONKAR S. NARULA, PHILIP SAMET
Journal: Circulation (1969)

A case of atrial tachysystole with apparent exit block is reported in which the basic cycle length of atrial activity is 260 msec. Simultaneous right intra-atrial electrograms show cycle lengths of 510 to 780 msec which are roughly multiples of 260 msec establishing the diagnosis of exit block. Rapid atrial stimulation (1,200/min) to overdrive the rapid ectopic atrial pacemaker was only transiently successful in converting the arrhythmia to atrial fibrillation with a slower ventricular response. Two days later the rhythm converted to normal sinus rhythm (cycle length, 600 msec) with periods of sino-atrial block measuring 2,400 and 1,240 msec. Atrial rate further slowed so that the patient ultimately required a permanent demand pacemaker. The case supports the theory of repetitive discharge from an ectopic atrial pacemaker to explain the mechanism producing atrial tachysystoles that simulate atrial flutter.
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
Authors: Osamu Adachi, Taro Kawai, Kiyoshi Takeda, Makoto Matsumoto, Hiroko Tsutsui, Masafumi Sakagami, Kenji Nakanishi, Shizuo Akira
Journal: Immunity (1998)
LATE DECLINE IN RENAL FUNCTION FOLLOWING IMPLANTATION OF CONTINUOUS FLOW LEFT VENTRICULAR ASSIST DEVICES
Authors: Tal Hasin, Yan Topilsky, John Schirger, Zhuo Li, Barry Boilson, Alfredo Clavell, Richard Rodeheffer, Robert Frantz, Brooks Edwards, Naveen Pereira, Lyle Joyce, Richard Daly, Soon Park, Sudhir Kushwaha
Journal: Journal of the American College of Cardiology (2012)
Predictors of Smoking Initiation and Cessation Among Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study
Authors: K. Emmons
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To examine the determinants of smoking behavior among participants in the Childhood Cancer Survivors Study (CCSS). METHODS: This retrospective cohort survey study was conducted among 9,709 childhood cancer survivors. Main outcomes included smoking initiation and cessation. RESULTS: Twenty-eight percent of patients reported ever smoking and 17% reported being current smokers. Standardized to United States population rates, the observed to expected (O/E) ratios and corresponding 95% confidence limits (95% CL) of cigarette smoking were 0.72 (95% CL, 0.69, 0.75) among all survivors and 0.71 (95% CL, 0.68 to 0.74) and 0.81 (95% CL, 0.70, 0.93) among whites and nonwhites, respectively. Significantly lower O/E ratios were present among both males (O/E, 0.73) and females (O/E, 0.70). Factors independently associated with a statistically significant relative risk of smoking initiation included older age at cancer diagnosis, lower household income, less education, not having had pulmonary-related cancer treatment, and not having had brain radiation. Blacks were less likely to start smoking. Survivors who smoked were significantly more likely to quit (O/E, 1.22; 95% CL, 1.15, 1.30). Among ever-smokers, factors associated with the likelihood of being a current smoker included age less than 13 years at smoking initiation, less education, and having had brain radiation; those age less than 3 years at cancer diagnosis were significantly more likely to be ex-smokers. CONCLUSIONS: Although survivors in the CCSS cohort seem to be smoking at rates below the general population, interventions are needed to prevent smoking initiation and promote cessation in this distinct population.
1078-93 Enhanced angiogenesis with autologous bone marrow transplantation in a porcine nonreperfused myocardial infarction model
Authors: Ron Waksman, Jana A Fournadjiev, Richard Baffour, Laurent Leborgne, Rajbabu Pakala, David Hellinga, Hamid Yazdi, Edouard Cheneau, Roswitha Wolfram, Rufus Seabron, Keneth Horton, Frank Kolodgie, Renu Virmani, Elias Rivera
Journal: Journal of the American College of Cardiology (2004)
Amiodarone Prophylaxis Reduces Major Cardiovascular Morbidity and Length of Stay after Cardiac Surgery: A Meta-Analysis
Authors: Johan D. Aasbo, Andrew T. Lawrence, Kousik Krishnan, Michael H. Kim, Richard G. Trohman
Journal: Annals of Internal Medicine (2005)

Although evidence supports the prophylactic use of β-blockade in cardiac surgery, postoperative atrial fibrillation or flutter occurs in 40% to 60% of patients. Trials that assessed whether amiodarone prophylaxis decreases the incidence of postoperative atrial tachyarrhythmias have had mixed results and were not specifically powered to detect changes in cardiovascular morbidity, length of stay, or mortality.
Arterial hemodynamic indexes in Marfan's syndrome.
Authors: F C Yin, K P Brin, C T Ting, R E Pyeritz
Journal: Circulation (1989)

Aortic impedance, wave reflection magnitude, and compliance were measured in patients with Marfan's syndrome during diagnostic cardiac catheterization. Impedance and wave reflections were calculated from standard Fourier series analysis of ascending aorta micromanometer pressure and electromagnetic flow records. Compliance was estimated by a method recently proposed that uses the area under the pressure-time curve assuming a two-element Windkessel model of the circulation. Measurements were made in the baseline state, during vasodilatation with nitroprusside, after beta-adrenergic receptor blockade with intravenous propranolol, and during vasodilatation after beta-blockade. Marfan's syndrome produces alterations from normal in some hemodynamic variables: during baseline conditions, the magnitude of wave reflection was higher than in normal patients. This was normalized by vasodilatation and further increased by beta-blockade. Despite the greatly dilated aortic root, the aortic characteristic impedance was in the normal range, suggesting increased aortic wall stiffness. The baseline total arterial compliance was greatly increased with nitroprusside and was reduced by beta-blockade. beta-Blockade did not decrease the maximum acceleration of blood into the ascending aorta. These are the first detailed measurements of hemodynamic indexes in this disease. The results suggest that acute beta-blockade is not necessarily beneficial in reducing hemodynamic loading on an already dilated aortic root.
376. Hepatic Tropism of Adenoviral Type 5 Vectors Can Be Mediated by Multiple Coagulation Factors
Authors: Alan L. Parker, Campbell G. Nicol, Simon N. Waddington, Suzanne M. Buckley, Dmitry M. Shayakhmetov, Shaoheng H. Ni, Andre Lieber, John H. McVey, Laura Denby, Stuart A. Nicklin, Andrew H. Baker
Journal: Molecular Therapy (2006)

A recent study demonstrated that Factor IX (FIX) directly binds the adenoviral (Ad) fibre knob domain |[ldquo]|bridging|[rdquo]| viral uptake into hepatocytes via heparan sulphate proteoglycans (HSPG) and/or low-density lipoprotein receptor related protein (LRP)1. In vivo, this phenomenon compensates for introduced capsid mutations abrogating CAR binding, accounting for the identical liver transduction levels of Ad5 vectors independent of CAR-binding status.
Diagnosis of Uveo-parotid Fever by 67Ga-Citrate Imaging
Authors: VICTOR O. OREN, J MICHAEL USZLER, JACK WHITE
Journal: Clinical Nuclear Medicine (1978)

67Ga-citrate scan from skull to mid-abdomen showed increased uptake in both parotid glands, mediastinum, lungs, uvei and/or enlarged lacrimal glands. The differential diagnosis of the positive radiogallium scan is discussed with emphasis on the value of the extrathoracic findings. Tissue diagnosis confirmed the imaging diagnosis of sarcoidosis. The case illustrates the usefulness of double radionuclide study—67Ga and 99mTc-MAA—and of the tomographic scanner in defining the spread of the active granulomatous disease.
SENSITIVITY TO METHYLENE BLUE AND FINAL ACIDITY OF NON-HEMOLYTIC STREPTOCOCCI
Authors: Roy C. Avery
Journal: The Journal of Experimental Medicine (1929)

The results of the present study may be briefly summarized as follows. Acid production and sensitivity to methylene blue of 55 strains of methemoglobin-forming streptococci from various sources were studied to determine whether it is possible on the basis of these reactions to differentiate strains of human, bovine, and dairy origin. Twelve strains were isolated from human infections, 6 from bovine mastitis, and 37 from dairy products. The final hydrogen ion concentrations of all cultures in dextrose broth regardless of the sources from which the strains originated, covered the range pH 5.2 to 4.1. There appeared, therefore, to be no correlation between the amount of acid produced by a given strain and the source from which it was originally derived. Low acid production, a characteristic of hemolytic streptococci of the human type, was not a distinguishing mark of the green producing organisms from human infection, and high acid production was not limited to strains from bovine and dairy sources. Differences between saprophytic and parasitic strains in their sensitivity to methylene blue in milk were not so sharply defined as were those previously demonstrated for the hemolytic streptococci. Of 18 strains of human and bovine infections, 14 showed neither reduction nor growth in the presence of a 1.5000 concentration of methylene blue. Of the 38 strains from dairy products 32 reduced the dye and grew in this concentration. The results with the non-hemolytic streptococci indicate that the saprophytic strains have a greater tolerance for the dye than have the strains of parasitic origin. The significance of these results in the differentiation of streptococci of human, bovine and dairy origin is discussed.
Traumatic osteochondral lesions of the talus.
Authors: A. Israeli, A. Ganel, H. Horoszowski, I. Farine
Journal: British Journal of Sports Medicine (1981)

The  is a common site of sports injuries. Extreme violent inversion of the  associated with sports accidents, subjects it to traumas of varying degrees. Fractures of the medial and lateral malleoli, and tears of the ligaments are easily recognisable. When these are excluded on the X-ray examination, the diagnosis of   is usually made and fast spontaneous recovery is expected. However, some of these patients continue to suffer from pain, limitation of movement and long periods of sport incapacity. These cases of unresolving ankle sprain were related to post traumatic osteochondral lesions of the talus (Smith et al, 1977).
Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts
Authors: Amy R. Stagg, Judith C. Fleming, Meghan A. Baker, Massayuki Sakamoto, Nadine Cohen, Ellis J. Neufeld
Journal: Journal of Clinical Investigation (1999)

We have investigated the cellular pathology of the syndrome called thiamine-responsive megaloblastic anemia (TRMA) with diabetes and deafness. Cultured diploid fibroblasts were grown in thiamine-free medium and dialyzed serum. Normal fibroblasts survived indefinitely without supplemental thiamine, whereas patient cells died in 5-14 days (mean 9.5 days), and heterozygous cells survived for more than 30 days. TRMA fibroblasts were rescued from death with 10-30 nM thiamine (in the range of normal plasma thiamine concentrations). Positive terminal deoxynucleotide transferase-mediated dUTP nick end-labeling (TUNEL) staining suggested that cell death was due to apoptosis. We assessed cellular uptake of [3H]thiamine at submicromolar concentrations. Normal fibroblasts exhibited saturable, high-affinity thiamine uptake (Km 400-550 nM; Vmax 11 pmol/min/10(6) cells) in addition to a low-affinity unsaturable component. Mutant cells lacked detectable high-affinity uptake. At 30 nM thiamine, the rate of uptake of thiamine by TRMA fibroblasts was 10-fold less than that of wild-type, and cells from obligate heterozygotes had an intermediate phenotype. Transfection of TRMA fibroblasts with the yeast thiamine transporter gene THI10 prevented cell death when cells were grown in the absence of supplemental thiamine. We therefore propose that the primary abnormality in TRMA is absence of a high-affinity thiamine transporter and that low intracellular thiamine concentrations in the mutant cells cause biochemical abnormalities that lead to apoptotic cell death.