The Promise of Disease Proteomics: Faster Detection, Diagnosis, and Drug Development
Authors: Jennifer Fisher Wilson
Journal: Annals of Internal Medicine (2004)

Current Clinical Issues17 February 2004The Promise of Disease Proteomics: Faster Detection, Diagnosis, and Drug DevelopmentJennifer Fisher WilsonJennifer Fisher WilsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-4-200402170-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The world of proteins is complex and fast-moving. More than a million distinct proteins course the body. The type and number of proteins fluctuate continuously, depending, for example, on whether a person is asleep or awake, hungry or full, sick or healthy. Proteins constantly send messages, regulate cell division, influence tissue growth, transport oxygen, and block infection. In sum, they carry out all of the body's vital functions.Until recently, acquiring a snapshot of every protein in the body at any one time—called a proteome—was considered impossible. But today, scientists are beginning to harness the power of microarray chips and ...References1. Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, et al . Use of proteomic patterns in serum to identify ovarian cancer. Lancet. 2002;359:572-7. [PMID: 11867112] CrossrefMedlineGoogle Scholar2. Petricoin EF, Ornstein DK, Paweletz CP, Ardekani A, Hackett PS, Hitt BA, et al . Serum proteomic patterns for detection of prostate cancer. J Natl Cancer Inst. 2002;94:1576-8. [PMID: 12381711] CrossrefMedlineGoogle Scholar3. Petricoin EF. Tracking protein patterns may cut biopsy rates for prostate cancer. Presentation at American Association for Cancer Research, Abstract 5736. 13 July 2003. Google ScholarFurther Reading Hanash S. Hanash S. Disease proteomics. Nature. 2003;422:226-32. [PMID: 12634796] CrossrefMedlineGoogle Scholar Liotta LA, Ferrari M, Petricoin E. Liotta LA, Ferrari M, Petricoin E. Clinical proteomics: written in blood. Nature. 2003;425:905. [PMID: 14586448] CrossrefMedlineGoogle Scholar Service RF. Service RF. Proteomics. Public projects gear up to chart the protein landscape. Science. 2003;302:1316-8. [PMID: 14631011] CrossrefMedlineGoogle Scholar Proteins on Demand. Proteins on Demand. Technology Review. 4 October 2001. Google Scholar Author, Article, and Disclosure InformationAffiliations: Disclosures: None disclosed.E-mail:[email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMass spectrometric analysis of prefrontal cortex proteins in schizophrenia and bipolar disorderDevelopment and validation of a novel protein extraction methodology for quantitation of protein expression in formalin-fixed paraffin-embedded tissues using western blottingChapter 63 The future of stroke prevention by risk factor modificationMining the archival formalin-fixed paraffin-embedded tissue proteome: opportunities and challengesColorectal cancer: current care, future innovations and economic considerationsProteomicsAGA Future Trends Committee Report: Colorectal Cancer: A Qualitative Review of Emerging Screening and Diagnostic TechnologiesDisease proteomics toward bedside realityProteomics: A Paradigm Shift 17 February 2004Volume 140, Issue 4Page: 317-319KeywordsBiopsyBloodBlood plasmaDrugsOvarian cancerProstate cancerProteinsProteomicsScientistsSerum proteins ePublished: 17 February 2004 Issue Published: 17 February 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...