tbuckley/cabot-search huggingface dataset:
Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system
Authors: So Jin Lee, Heebeom Koo, Dong-Eun Lee, Solki Min, Seulki Lee, Xiaoyuan Chen, Yongseok Choi, James F. Leary, Kinam Park, Seo Young Jeong, Ick Chan Kwon, Kwangmeyung Kim, Kuiwon Choi
Journal: Biomaterials (2011)
2009 H1N1 Influenza and Pregnancy — 5 Years Later
Authors: Sonja A. Rasmussen, Denise J. Jamieson
Journal: New England Journal of Medicine (2014)

Severe influenza illnesses, hospitalizations, and deaths among pregnant women were reported during the last U.S. influenza season, when the 2009 H1N1 pandemic strain was again the predominant circulating virus. What lessons can we apply from the 2009 pandemic?
Carcinogenic and Cocarcinogenic Effects of Radon and Radon Daughters in Rats.
Authors: G Monchaux, JP Morlier, M Morin, J Chameaud, J Lafuma, R Masse
Journal: Environmental Health Perspectives (1994)

It has been previously established that lung cancer could be induced in rats by exposure to radon and radon daughters. Although the oat-cell carcinomas that are common in humans were not found in rats, other histological types of lung carcinomas, especially squamous cell carcinomas and primitive lung adenocarcinomas, were similar to those observed in humans. A dose-effect relationship was established for cumulative doses varying from 25 to 3000 working-level-months (WLM), which was similar for medium and high cumulative doses to that observed in uranium miners. This experimental protocol was also used to study the potential cocarcinogenic effects of other environmental or industrial airborne pollutants such as tobacco smoke, mineral fibers, diesel exhausts, or minerals from metallic mine ores that may act synergistically with radon exposure. In rats exposed to radon and tobacco smoke combined, the incidence of lung cancers was higher by a factor of 2-4 according to the cumulative radon exposure and the duration of tobacco smoke exposure. When mineral fibers were injected intrapleurally, an increased incidence of malignant thoracic tumors was observed in rats exposed to radon and fibers combined, but synergistic effects resulted in additivity. With diesel exhausts or minerals from metallic ores, a slight, nonsignificant increase in the incidence of lung carcinomas was observed compared with rats exposed to radon alone. These results demonstrated that it is possible to establish the potential cocarcinogenic action, showing either multiplicative, additive, or no effect of various environmental or industrial airborne pollutants combined with radon exposure. This radon model is valid for investigating possible interactions between two occupational exposures.
Impact of environment, stress, occupational, and other hazards on sexuality and sexual behavior.
Authors: J Bancroft
Journal: Environmental Health Perspectives (1993)

Sexual health is important for general as well as reproductive health. The effects of the environment on sexual health are complex, however, because of the psychosomatic nature of human sexuality. The effects of any specific environmental agent on sexual function will therefore be modified or amplified by psychosocial factors, and any assessment of the effects of the agent will need to take those factors into account. As a consequence, we have little direct evidence of the adverse effects of the environment on sexuality. This paper therefore considers a) the aspects of sexuality that may by susceptible to environmental effects and the likely mediating mechanisms. These are considered under three headings: psychophysiological, endocrine, and subjective/interpersonal; b) the types of relevant environmental factors, including toxic pollutants, self-administered toxins, diet, situational factors, adversity, stress, and social and cultural factors. As yet research has not controlled adequately for the various confounding factors. It is suggested that a first step is to investigate the effects of work stress (e.g., shift and night work) on sexual relationships, comparing the effects across contrasting cultural settings. Such research would then provide a basis for cross-cultural study of other environmental factors.
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
Authors: Walter Halangk, Markus M. Lerch, Barbara Brandt-Nedelev, Wera Roth, Manuel Ruthenbuerger, Thomas Reinheckel, Wolfram Domschke, Hans Lippert, Christoph Peters, Jan Deussing
Journal: Journal of Clinical Investigation (2000)

Autodigestion of the pancreas by its own prematurely activated digestive proteases is thought to be an important event in the onset of acute pancreatitis. The mechanism responsible for the intrapancreatic activation of digestive zymogens is unknown, but a recent hypothesis predicts that a redistribution of lysosomal cathepsin B (CTSB) into a zymogen-containing subcellular compartment triggers this event. To test this hypothesis, we used CTSB-deficient mice in which the ctsb gene had been deleted by targeted disruption. After induction of experimental secretagogue-induced pancreatitis, the trypsin activity in the pancreas of ctsb(-/-) animals was more than 80% lower than in ctsb(+/+) animals. Pancreatic damage as indicated by serum activities of amylase and lipase, or by the extent of acinar tissue necrosis, was 50% lower in ctsb(-/-) animals. These experiments provide the first conclusive evidence to our knowledge that cathepsin B plays a role in intrapancreatic trypsinogen activation and the onset of acute pancreatitis.
TCT-505 Impact of coronary artery disease presence on the long-term follow-up of carotid artery stenting
Authors: Salech Arif, Stanislaw Bartus, Artur Dziewierz, Tomasz Rakowski, Michał Brzeziński, Michał Chyrchel, Dariusz Dudek
Journal: Journal of the American College of Cardiology (2013)
Ups and downs of balloon times
Authors: B. A Cattle, D. C Greenwood, C. P Gale, R. M West
Journal: BMJ (2009)

In the United States, treatment of ST elevation myocardial infarction by primary percutaneous coronary intervention is most effective if given within 90 minutes after admission to hospital.1 In the United Kingdom, the 90 minute door-to-balloon time is likely to …
Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile
Authors: Mario S. Verani, Mohamed O. Jeroudi, John J. Mahmarian, Terri M. Boyce, Salvador Borges-Neto, Bharat Patel, Roberto Bolli
Journal: Journal of the American College of Cardiology (1988)
Increased airway smooth muscle in preschool wheezers who have asthma at school age
Authors: Ruth O'Reilly, Nicola Ullmann, Samantha Irving, Cara J. Bossley, Samatha Sonnappa, Jie Zhu, Timothy Oates, Winston Banya, Peter K. Jeffery, Andrew Bush, Sejal Saglani
Journal: Journal of Allergy and Clinical Immunology (2012)
Response to Letter Regarding Article, “Causes of Death and Influencing Factors in Patients With Atrial Fibrillation: A Competing-Risk Analysis From the Randomized Evaluation of Long-Term Anticoagulant Therapy Study”
Authors: Eloi Marijon, Jean-Yves Le Heuzey, Stuart Connolly, Sean Yang, Janice Pogue, Martina Brueckmann, John Eikelboom, Ellison Themeles, Michael Ezekowitz, Lars Wallentin, Salim Yusuf
Journal: Circulation (2014)
Wood-Smoke Exposure as a Response and Survival Predictor in Erlotinib-treated Non-small Cell Lung Cancer Patients: An Open Label Phase II Study
Authors: Oscar Arrieta, Luis Martinez-Barrera, Sergio Treviño, Enrique Guzman, Patricia Castillo-Gonzalez, Miguel Angel Rios-Trejo, Diana Flores-Estrada, Eduardo Téllez, Cesar Gonzalez, Johny de la Cruz Vargas, Claudia Haydee Gonzalez-De la Rosa, Norma Hernandez-Pedro, Rafael Morales-Barrera, Jaime De la Garza
Journal: Journal of Thoracic Oncology (2008)
Comparison Of Plasma Kallikrein Inhibition By The Monoclonal Antibody Inhibitor DX-2930 To Endogenous C1-INH
Authors: Daniel Sexton, Jon Kenniston, Ryan Faucette, Andrew Nixon, Christopher TenHoor, Yung H. Chyung, Burt Adelman
Journal: Journal of Allergy and Clinical Immunology (2014)
Alterations in carotid sinus reflex control of arterial hemodynamics associated with experimental hyperlipemia in the racing greyhound.
Authors: R H Cox, R J Bagshaw, D K Detweiler
Journal: Circulation Research (1980)

We administered a high cholesterol diet to racing greyhounds and studied its effects on the characteristics of carotid sinus reflex control of arterial pressure-flow relations. Dogs were anesthetized with halothane, and pressure and flow were simultaneously measured in the ascending aorta and the celiac, mesenteric, renal, and iliac arteries. The carotid sinuses were isolated bilaterally and perfused with a physiological salt solution under controlled conditions. The variation of regional pressure-flow relations and regional vascular resistance was assessed as a function of mean carotid sinus pressure (MCSP) with the vagi bilaterally sectioned to eliminate aortic arch afferents. Some differences were found in set point (i.e., MCSP = mean arterial pressure) values of hemodynamic variables; cardiac output and renal and iliac flows were significantly lower. Control and set point values of mean arterial pressure were not significantly different between the two groups. The variation of every hemodynamic variable with the exception of heart rate with carotid sinus pressure was attenuated markedly in the diet-treated dogs. Substantial lesions were found involving the entire carotid sinus region of every diet-fed animal. These results suggest that pathological alterations in the carotid sinus region are at least in part responsible for a reduction in the sensitivity of carotid sinus baroreflexes associated with atherosclerosis.
RNA expression patterns change dramatically in human neutrophils exposed to bacteria
Authors: Yerramilli V. B. K. Subrahmanyam, Shigeru Yamaga, Yatindra Prashar, Helen H. Lee, Nancy P. Hoe, Yuval Kluger, Mark Gerstein, Jon D. Goguen, Peter E. Newburger, Sherman M. Weissman
Journal: Blood (2001)
Exercise-induced Arteriovenous Intrapulmonary Shunting in Dogs
Authors: Michael K. Stickland, Andrew T. Lovering, Marlowe W. Eldridge
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Rationale: We have previously shown, using contrast echocardiography, that intrapulmonary arteriovenous pathways are inducible in healthy humans during exercise; however, this technique does not allow for determination of arteriovenous vessel size or shunt magnitude.Objectives: The purpose of this study was to determine whether large-diameter (more than 25 μm) intrapulmonary arteriovenous pathways are present in the dog, and whether exercise recruits these conduits.Methods: Through the right forelimb, 10.8 million 25-μm stable isotope-labeled microspheres (BioPAL, Inc., Worcester, MA) were injected either at rest (n = 8) or during high-intensity exercise (6– 8 mph, 10–15% grade, n = 6). Systemic arterial blood was continuously sampled during and for 3 minutes after injection. After euthanasia, tissue samples were obtained from the heart, liver, kidney, and skeletal muscle. In addition, 25- and 50-μm microspheres were infused into four isolated dog lungs that were ventilated and perfused at constant pressures similar to exercise.Measurements and Main Results: Blood and tissue samples were commercially analyzed for the presence of microspheres. No microspheres were detected in the arterial blood or tissue samples from resting dogs. In contrast, five of six exercising dogs showed evidence of exercise-induced intrapulmonary arteriovenous shunting, as microspheres were detected in arterial blood and/or tissue. Furthermore, shunt magnitude was calculated to be 1.4 ± 0.8% of cardiac output (n = 3). Evidence of intrapulmonary arteriovenous anastomoses was also found in three of four isolated lungs.Conclusions: Consistent with previous human findings, these data demonstrate that intrapulmonary arteriovenous pathways are functional in the dog and are recruited with exercise.
HFEA allows women to donate eggs for research
Authors: Susan Mayor
Journal: BMJ (2007)

Cyclo-oxygenase-2 (COX 2) inhibitors should be used only as the last choice after other types of non-steroidal anti-inflammatory drugs (NSAIDs) to relieve chronic pain in people with heart disease or at high risk of it, the American Heart Association has recommended.Its statement, published online in Circulation on 26 February (http://circ.ahajournals.orgdoi:10.1161/circulationaha.106.181424), was designed to end any remaining confusion about the cardiovascular risk of these agents.The association has recommended a stepped approach to treatment.The first step should be non-pharmacological approaches, such as physical therapy and weight loss, for patients with known cardiovascular disease or with risk factors for ischaemic heart disease.Drug treatment should start with agents with the lowest reported risk of cardiovascular events, before other agents are prescribed, and at each step account should be taken of the risk-benefit balance.First line drug choices include paracetamol (acetaminophen), aspirin, tramadol, and short term use of other narcotic analgesics.If these fail to achieve adequate pain control, the next option is non-acetylated salicylates, such as naproxen.The association recommended NSAIDs that aren't COX 2 inhibitors if pain is still inadequately controlled, then NSAIDs with some COX 2 activity as the next step, and lastly COX 2 selective NSAIDs.The committee considered the risk of all three of these classes to be sufficiently high to require that patients taking them should be monitored regularly for sustained hypertension (or worsening of prior blood pressure control), oedema, worsening renal function, or gastrointestinal bleeding.See pp 436, 450. Save COX 2 inhibitors till last for cardiac patientsUK NEWS HFEA allows women to donate eggs for research, p445 World NEWS repeal law that puts "FdA on the payroll of the industry", p447 bmj.comUK government defeated on community treatment forms
A pilot study of risk-adapted radiotherapy and chemotherapy in patients with supratentorial PNET
Authors: Murali Chintagumpala, Tim Hassall, Shawna Palmer, David Ashley, Dana Wallace, Kimberly Kasow, Thomas E. Merchant, Matthew J. Krasin, Robert Dauser, Frederick Boop, Robert Krance, Shiao Woo, Robyn Cheuk, Ching Lau, Richard Gilbertson, Amar Gajjar
Journal: Neuro-Oncology (2008)

We undertook this study to estimate the event-free survival (EFS) of patients with newly diagnosed supratentorial primitive neuroectodermal tumor (SPNET) treated with risk-adapted craniospinal irradiation (CSI) with additional radiation to the primary tumor site and subsequent high-dose chemotherapy supported by stem cell rescue. Between 1996 and 2003, 16 patients with SPNET were enrolled. High-risk (HR) disease was differentiated from average-risk (AR) disease by the presence of residual tumor (M0 and tumor size > 1.5 cm2) or disseminated disease in the neuraxis (M1–M3). Patients received risk-adapted CSI: those with AR disease received 23.4 Gy; those with HR disease, 36–39.6 Gy. The tumor bed received a total of 55.8 Gy. Subsequently, all patients received four cycles of high-dose cyclophosphamide, cisplatin, and vincristine with stem cell support. The median age at diagnosis was 7.9 years; eight patients were female. Seven patients had pineal PNET. Twelve patients are alive at a median follow-up of 5.4 years. The 5-year EFS and overall survival (OS) estimates for all patients were 68% ± 14% and 73% ± 13%. The 5-year EFS and OS estimates were 75% ± 17% and 88% ± 13%, respectively, for the eight patients with AR disease and 60% ± 19% and 58% ± 19%, respectively, for the eight with HR disease. No deaths were due to toxicity. High-dose cyclophosphamide-based chemotherapy with stem cell support after risk-adapted CSI results in excellent EFS estimates for patients with newly diagnosed AR SPNET. Further, this chemotherapy allows for a reduction in the dose of CSI used to treat AR SPNET without compromising EFS.
DABIGATRAN VERSUS WARFARIN AND IMPACT OF CHAD2-VASC SCORE ON OUTCOME IN ATRIAL FIBRILLATION PATIENTS: A RE-LY SUBGROUP ANALYSIS
Authors: Jonas Oldgren, Michael D. Ezekowitz, Marco Alings, Hans-Christoph Diener, Paul A. Reilly, Salim Yusuf, Lars Wallentin, Stuart Connolly
Journal: Journal of the American College of Cardiology (2011)
PRACTICAL RULES FOR THE DIAGNOSIS OF CARDIC ARRHYTHMIAS
Authors: Maurice Lewison
Journal: JAMA (1923)

Sinus arrythmia is the common irregularity of the young; premature contractions cause the common irregularity of those past middle life. The absence of a predominant rhythm indicates auricular fibrillation. Comparison of the heart rate, as determined by auscultation with the pulse rate, will show a pulse deficit in all conditions excepting heart block and sinus arrhythmia. When the pulse rate is increased by exercise, the irregularity is decreased or made to disappear when caused by premature contractions or sinus arrhythmia, and is increased in auricular fibrillation. Deep breathing increases the irregularity in sinus arrhythmia. A rapid regular pulse, persisting under rest treatment, indicates paroxysmal tachycardia or auricular flutter. If the jugular are compared with the radial pulsations, the jugular pulsations will be found absent in fibrillation and more rapid in heart block. If the pulse is compressed with the cuff of a sphygmomanometer, a pulse deficit will be increased in
Deep Brain Stimulation for Neurological Disorders
Authors: Chima O. Oluigbo, Asem Salma, Ali R. Rezai
Journal: IEEE Reviews in Biomedical Engineering (2012)

Deep brain stimulation (DBS) involves the delivery of precise electrical signals to specific deep anatomical structures of the central nervous system, with the objective of altering or modulating neural functioning and achieving a reversible, adjustable and therapeutic or clinically beneficial effect.
Hormone levels and fuel flow in patients with weight loss and lung cancer. Evidence for excessive metabolic expenditure and for an adaptive response mediated by a reduced level of 3,5,3′-triiodothyronine
Authors: Lloyd Axelrod, Jeffrey B. Halter, David S. Cooper, Thomas T. Aoki, Anne M. Roussell, Suzanne L. Bagshaw
Journal: Metabolism (1983)
Mother's Milk Turns Toxic Following Fish Feast
Authors: Donald P. de Sylva
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Ten people ingested a presumed ciguatera-affected fish. Eleven people developed clinical symptoms of ciguatera fish toxicity. The 11th victim was a 4-month-old breast-feeding infant. He was nursed approximately 1 hour and 3 hours after his mother's fish meal. A large kingfish was caught at Cay Sal Bank in the Bahamas. The infant's mother and all other nine who ingested the fish developed the classic symptoms of ciguatera toxicity. This included vomiting, diarrhea, and abdominal pain approximately 14 hours after ingestion of the kingfish. Within a few hours, tingling and numbness, pin-prickling sensation of the hands and feet, and reversal of cold-hot sensory discrimination, typical of ciguatera poisoning, were noted in all 10. In addition, most developed joint and muscle pain, generalized myalgia, dizziness, intense pruritus, and weakness in the legs. Approximately 10 hours after the infant was first breast-fed following his mother's kingfish meal, he became "colicky"
Medicare Case Underlines Importance of Physician Compliance With All Rules When Claims Are Filed
Authors: Charles Marwick
Journal: JAMA (1993)

THIS NEW YEAR begins with yet another cautionary message for physicians. It accompanies news of what is held to be the largest settlement ever in a Medicare fraud case—$111.4 million— just reached with a plea of guilty by National Health Laboratories, Inc, La Jolla, Calif, one of the major medical laboratory chains in the country, to charges of improper claims involving clinical testing procedures and the Medicare program. The settlement includes a fine of $1 million and $10.4 million in payments to state Medicaid programs as well as $100 million in repayments to Medicare, Medicaid, and the Civilian Health and Medical Program of the Uniformed Services. The president and chief executive officer of National Health, Robert E. Draper, also pleaded guilty to two counts of fraud and resigned from the company. He faces a possible maximum 10 years in prison and a $500 000 fine. <h3>Two Tests</h3> The case initially
Portal vein bile acids in patients with severe inflammatory bowel disease
Authors: R T Holzbach, M E Marsh, M R Freedman, V W Fazio, I C Lavery, D A Jagelman
Journal: Gut (1980)

The incidence of several forms of liver disease associated with inflammatory bowel disease has been putatively ascribed to a toxic effect on the liver of portal vein bile acids abnormal in type or amount. To examine this possibility, total bile acid concentrations (sulphated and non-sulphated) were measured by gas-liquid chromatography in inferior mesentric vein serum of 19 patients undergoing colectomy for severe inflammatory bowel disease (IBD). Similar determinations were obtained on a control group of eight patients requiring colectomy for other non-inflammatory conditions. Mean values for mesenteric vein serum bile acid concentrations (μM/1) were 19·6±1·8 in controls and 16·3±2·0 in IBD. The mean sulphated bile acid fraction did not exceed 10% of total, although there was considerable variability (up to 40% of total). Lithocholic acid levels (entirely sulphated in all patients) were low. Although the IBD group showed a more than two-fold increase in mean lithocholate concentration (0·54±0·15 μM/1) over controls (0·21 ± μM/1), this difference was not statistically significant. No significant intra-group difference was noted in the non-sulphated and sulphated fractions for cholic, chenodeoxycholic, and deoxycholic acid species, respectively. No unidentified or unusual bile acids were observed. There was no correlation between bile acid measurements and liver histology. These findings fail to support the hypothesis that liver disease often found in association with severe inflammatory bowel disease represents a form of bile acid toxicity. The invariable finding of total sulphation of the lithocholic acid fraction even in the presence of severe mucosal disease was unexpected.
Endosomal escape and transfection efficiency of PEGylated cationic liposome–DNA complexes prepared with an acid-labile PEG-lipid
Authors: Chia-Ling Chan, Ramsey N. Majzoub, Rahau S. Shirazi, Kai K. Ewert, Yen-Ju Chen, Keng S. Liang, Cyrus R. Safinya
Journal: Biomaterials (2012)