Update in Hospital Medicine: Evidence Published in 2013
Authors: Aaron J. Calderon, James S. Newman, Neil H. Winawer
Journal: Annals of Internal Medicine (2014)

Updates15 July 2014Update in Hospital Medicine: Evidence Published in 2013Aaron J. Calderon, MD, James S. Newman, MD, and Neil H. Winawer, MDAaron J. Calderon, MDFrom Emory University, Atlanta, Georgia; Mayo Clinic, Rochester, Minnesota; and Exempla Saint Joseph Hospital, Denver, Colorado.Search for more papers by this author, James S. Newman, MDFrom Emory University, Atlanta, Georgia; Mayo Clinic, Rochester, Minnesota; and Exempla Saint Joseph Hospital, Denver, Colorado.Search for more papers by this author, and Neil H. Winawer, MDFrom Emory University, Atlanta, Georgia; Mayo Clinic, Rochester, Minnesota; and Exempla Saint Joseph Hospital, Denver, Colorado.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0266 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this Update in Hospital Medicine, we present and discuss our choices of influential, practice-changing medical studies that were published in 2013. Two studies look at the prevention and treatment of Clostridium difficile infection (CDI), and 4 address intensive care unit (ICU) topics related to transfusion thresholds in severe gastrointestinal bleeding, prone positioning in acute respiratory distress syndrome (ARDS), a drug cocktail for cardiac arrest, and the controversial practice of screening for methicillin-resistant Staphylococcus aureus (MRSA) infection. Three studies address optimum inpatient management of diabetes and exacerbations of chronic obstructive pulmonary disease (COPD) and heart failure. Finally, because no hospital ...References1. Pereira TV, Horwitz RI, Ioannidis JP. Empirical evaluation of very large treatment effects of medical interventions. JAMA. 2012;308:1676-84. [PMID: 23093165] CrossrefMedlineGoogle Scholar2. Bassler D, Matthias B, Montori VM, Lane M, Glasziou P, Zhou Q, et al; STOPIT-2 Study Group. Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA. 2010;303:1180-7. [PMID: 20332404] CrossrefMedlineGoogle Scholar3. Johnston BC, Ma SS, Goldenberg JZ, Thorlund K, Vandvik PO, Loeb M, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann Intern Med. 2012;157:878-88. [PMID: 23362517] LinkGoogle Scholar4. 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[PMID: 22833635] CrossrefMedlineGoogle Scholar8. Patel JB, Gorwitz RJ, Jernigan JA. Mupirocin resistance. Clin Infect Dis. 2009;49:935-41. [PMID: 19673644] CrossrefMedlineGoogle Scholar9. Umpierrez GE, Hellman R, Korytkowski MT, Kosiborod M, Maynard GA, Montori VM, et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2012;97:16-38. [PMID: 22223765] CrossrefMedlineGoogle Scholar10. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2013. Accessed at www.goldcopd.org/uploads/users/files/GOLD_Report_2013_Feb20.pdf on 18 January 2014. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Emory University, Atlanta, Georgia; Mayo Clinic, Rochester, Minnesota; and Exempla Saint Joseph Hospital, Denver, Colorado.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-0266.Corresponding Author: Neil H. Winawer, MD, Emory University, 49 Jessie Hill Jr. Drive SE, Atlanta, GA 30303; e-mail, [email protected]edu.Current Author Addresses: Dr. Calderon: Exempla Saint Joseph Hospital, 1835 Franklin Street, Denver, CO 80218-1191.Dr. Newman: Mayo Clinic, 200 First Street SW, Rochester, MN 55905.Dr. Winawer: Emory University, 49 Jessie Hill Jr. Drive SE, Atlanta, GA 30303.Author Contributions: Conception and design: A.J. Calderon.Analysis and interpretation of the data: A.J. Calderon, N.H. Winawer.Drafting of the article: A.J. Calderon, J.S. Newman, N.H. Winawer.Critical revision of the article for important intellectual content: A.J. Calderon, J.S. Newman, N.H. Winawer.Final approval of the article: A.J. Calderon, J.S. Newman, N.H. Winawer.This article was published online first at www.annals.org on 10 April 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 2014Volume 161, Issue 2Page: 139-144KeywordsAcute respiratory distress syndromeAntibioticsHeart failureHemorrhageInsulinIntensive care unitsMethicillin-resistant Staphylococcus aureus ePublished: 15 July 2014 Issue Published: 15 July 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...