Protease Inhibitors and Prohormone Processing
Authors: Raphael B. Stricker
Journal: Annals of Internal Medicine (2000)

Letters19 September 2000Protease Inhibitors and Prohormone ProcessingRaphael B. Stricker, MD and Billi Goldberg, MPARaphael B. Stricker, MDCalifornia Pacific Medical Center; San Francisco, CA 94120 (Stricker)International DNCB Study Group; San Francisco, CA 94114 (Goldberg)Search for more papers by this author and Billi Goldberg, MPACalifornia Pacific Medical Center; San Francisco, CA 94120 (Stricker)International DNCB Study Group; San Francisco, CA 94114 (Goldberg)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-6-200009190-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Danoff and Ling (1) cite our article (2) as the basis for proposing that HIV protease inhibitor therapy may interfere with proinsulin processing, leading to hyperglycemia. They then demonstrate that this is not the case by using an in vitro cell culture system.We did not propose that HIV protease inhibitor therapy leads to abnormal proinsulin processing. In fact, it is highly unlikely that HIV protease inhibitors, which block aspartic proteases, would interfere with the proinsulin-converting enzymes, which are serine proteases. Rather, HIV protease inhibitor therapy appears to block cellular cathepsin activity, leading to decreased degradation of ...References1. Danoff A, Ling WL. Protease inhibitors do not interfere with prohormone processing [Letter]. Ann Intern Med. 2000;132:330. LinkGoogle Scholar2. Goldberg B, Stricker RB. HIV protease and the pathogenesis of AIDS. Res Virol. 1996;147:375-9. CrossrefMedlineGoogle Scholar3. Stricker RB, Goldberg B. Weight gain associated with protease inhibitor therapy in HIV-infected patients. Res Virol. 1998;149:123-6. CrossrefMedlineGoogle Scholar4. Stricker RB, Goldberg B. “Buffalo humps” associated with protease inhibitors. [Letter]. Ann Intern Med. 1999;130:241-2. LinkGoogle Scholar5. Carr A, Miller J, Law M, Cooper DA. A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS. 2000;14:F25-32. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: California Pacific Medical Center; San Francisco, CA 94120 (Stricker)International DNCB Study Group; San Francisco, CA 94114 (Goldberg) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee Also“Buffalo Humps” Associated with Protease Inhibitors Raphael B. Stricker and Billi Goldberg Protease Inhibitors Do Not Interfere with Prohormone Processing Ann Danoff and Wai Lam W. Ling Protease Inhibitors and Prohormone Processing Ann Danoff and Wai Lam W. Ling Metrics 19 September 2000Volume 133, Issue 6Page: 482-483KeywordsHIVHyperglycemiaInsulin-like growth factorsNucleosidesProtease inhibitor therapyProtease inhibitorsProteasesSerine proteasesToxicityWeight gain ePublished: 19 September 2000 Issue Published: 19 September 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...