Update in Women's Health: Evidence Published in 2012
Authors: Megan McNamara*, Judith M.E. Walsh*
Journal: Annals of Internal Medicine (2013)

UpdatesAugust 6, 2013Update in Women's Health: Evidence Published in 2012Megan McNamara, MD, MSc* and Judith M.E. Walsh, MD, MPH*Megan McNamara, MD, MSc*From Case Western Reserve University, Cleveland, Ohio, and Women's Health Clinical Research Center, University of California, San Francisco, San Francisco, California.Search for more papers by this author and Judith M.E. Walsh, MD, MPH*From Case Western Reserve University, Cleveland, Ohio, and Women's Health Clinical Research Center, University of California, San Francisco, San Francisco, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-1-201307020-00104 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This update summarizes 10 important studies on Women's health published in 2012 that are relevant to primary care. Authors screened the literature using ACP JournalWise and Journal Watch Women's Health to identify articles for inclusion. The articles focus on 1 key theme: Clinicians should recommend preventive and therapeutic interventions that maximize patient benefit while minimizing harm.Studies finding increased risk for myocardial infarction (MI) with calcium supplementation, hip fracture with regular use of proton-pump inhibitors (PPIs), and venous thromboembolism (VTE) and stroke with the contraceptive ring will inform discussions about the risks and benefits of these therapies. Ulipristal acetate, which ...References1. Lidegaard Ø, Nielsen LH, Skovlund CW, Skjeldestad FE, and Løkkegaard E. Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9. BMJ. 2011;343:d6423. [PMID: 22027398] CrossrefMedlineGoogle Scholar2. Fleischer K, van Vliet HA, Rosendaal FR, Rosing J, Tchaikovski S, and Helmerhorst FM. 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Accessed at www.uspreventiveservicestaskforce.org/uspstf10/osteoporosis/osteors.htm on 3 March 2013. Google Scholar15. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010;341:c3691. [PMID: 20671013] CrossrefMedlineGoogle Scholar16. Bolland MJ, Grey A, Avenell A, Gamble GD, and Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. 2011;342:d2040. [PMID: 21505219] CrossrefMedlineGoogle Scholar17. Bolland MJ, Grey A, Gamble GD, and Reid IR. Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women's Health Initiative (WHI) limited-access data set. Am J Clin Nutr. 2011;94:1144-9. [PMID: 21880848] CrossrefMedlineGoogle Scholar18. Targownik LE, Metge C, Roos L, and Leung S. The prevalence of and the clinical and demographic characteristics associated with high-intensity proton pump inhibitor use. Am J Gastroenterol. 2007;102:942-50. [PMID: 17313495] CrossrefMedlineGoogle Scholar19. Yang YX, Lewis JD, Epstein S, and Metz DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947-53. [PMID: 17190895] CrossrefMedlineGoogle Scholar20. Corley DA, Kubo A, Zhao W, and Quesenberry C. Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. Gastroenterology. 2010;139:93-101. [PMID: 20353792] CrossrefMedlineGoogle Scholar21. Gray SL, LaCroix AZ, Larson J, Robbins J, Cauley JA, Manson JE, et al. Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative. Arch Intern Med. 2010;170:765-71. [PMID: 20458083] CrossrefMedlineGoogle Scholar22. Pouwels S, Lalmohamed A, Souverein P, Cooper C, Veldt BJ, Leufkens HG, et al. Use of proton pump inhibitors and risk of hip/femur fracture: a population-based case-control study. Osteoporos Int. 2011;22:903-10. [PMID: 20585937] CrossrefMedlineGoogle Scholar23. Targownik LE, Lix LM, Metge CJ, Prior HJ, Leung S, and Leslie WD. Use of proton pump inhibitors and risk of osteoporosis-related fractures. CMAJ. 2008;179:319-26. [PMID: 18695179] CrossrefMedlineGoogle Scholar24. Vestergaard P, Rejnmark L, and Mosekilde L. Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture. Calcif Tissue Int. 2006;79:76-83. [PMID: 16927047] CrossrefMedlineGoogle Scholar25. Yang YX. Proton pump inhibitor therapy and osteoporosis. Curr Drug Saf. 2008;3:204-9. [PMID: 18691003] CrossrefMedlineGoogle Scholar26. Yu EW, Blackwell T, Ensrud KE, Hillier TA, Lane NE, Orwoll E, et al. Acid-suppressive medications and risk of bone loss and fracture in older adults. Calcif Tissue Int. 2008;83:251-9. [PMID: 18813868] CrossrefMedlineGoogle Scholar27. U.S. Food and Drug Administration. FDA Drug Safety Communication: Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors. 2011. Accessed at www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm213206.htm on 28 February 2013. Google Scholar Author, Article, and Disclosure InformationAuthors: Megan McNamara, MD, MSc; Judith M.E. Walsh, MD, MPHAffiliations: From Case Western Reserve University, Cleveland, Ohio, and Women's Health Clinical Research Center, University of California, San Francisco, San Francisco, California.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-0263.Corresponding Author: Megan McNamara, MD, MSc, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106; e-mail, [email protected].Current Author Addresses: Dr. McNamara: Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106.Dr. Walsh: Women's Health Clinical Research Center, University of California, San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 94115.Author Contributions: Conception and design: M. McNamara, J.M.E. Walsh.Analysis and interpretation of the data: M. McNamara, J.M.E. Walsh.Drafting of the article: M. McNamara, J.M.E. Walsh.Critical revision of the article for important intellectual content: M. McNamara, J.M.E. Walsh.Final approval of the article: M. McNamara, J.M.E. Walsh.This article was published at www.annals.org on 11 April 2013.* Drs. McNamara and Walsh contributed equally to this work. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUpdate in Women's Health Megan C. McNamara and Judith M.E. Walsh Update in Women's Health Marjorie Jenkins , Tedd L. Mitchell , and Steven L. Berk Metrics Cited byUpdate in Women's HealthMarjorie Jenkins, MD, Tedd L. Mitchell, MD, and Steven L. Berk, MD August 6, 2013Volume 159, Issue 3Page: 203-209KeywordsBoneBreast cancerCalciumCell biologyCervical cancer screeningContraceptivesEstradiolEstrogensHip fracturesHormonal therapyHormonesMammographyMenopauseMyocardial infarctionObstetrics and gynecologyOsteopeniaOsteoporosisQuality of lifeStroke ePublished: 8 March 2020 Issue Published: August 6, 2013 PDF downloadLoading ...