tbuckley/cabot-search huggingface dataset:
Phosducin — a candidate gene for stress-dependent hypertension
Authors: Guido Grassi
Journal: Journal of Clinical Investigation (2009)

Repeated exposure to stress may favor, both in experimental animals and in humans, an increase in blood pressure, leading in some instances to a true hypertensive state. It is thought that stress-induced hypertension is mediated by sympathetic nervous system activation that in turn, by exerting vasoconstrictor effects and increasing heart rate (and thus cardiac output), may promote the development and progression of the hypertensive state. A new study by Beetz and colleagues in this issue of the JCI, which reports the results of experimental studies carried out in both mice and humans, reveals the potential role of the phosducin gene in modulating the adrenergic and blood pressure responses to stress (see the related article beginning on page 3597).
Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease
Authors: John P. Miller, Jennifer Holcomb, Ismael Al-Ramahi, Maria de Haro, Juliette Gafni, Ningzhe Zhang, Eugene Kim, Mario Sanhueza, Cameron Torcassi, Seung Kwak, Juan Botas, Robert E. Hughes, Lisa M. Ellerby
Journal: Neuron (2010)
Mitoses in normal and psoriatic epidermis
Authors: LYON ROWE, WILFRED J. DIXON, ALAN FORSYTHE
Journal: British Journal of Dermatology (1978)

The morning count of mitoses in uninvolved epidermis of psoriatics is not significantly different from normal skin. The afternoon count is higher than the morning in both, and significantly higher in uninvolved than in normal epidermis. These results may be interpreted as favouring the existence of a non‐cycling G2 population in human epidermis. This G2 population could be released into mitosis by the factors involved in diurnal variation, and might be larger and more labile in psoriatics than in normals. The pathogenesis and aetiology of psoriasis may be related to such a G2 population.
Short-term and long-term effects of psychosocial therapy for people after deliberate self-harm: a register-based, nationwide multicentre study using propensity score matching
Authors: Annette Erlangsen, Bertel Dam Lind, Elizabeth A Stuart, Ping Qin, Elsebeth Stenager, Kim Juul Larsen, August G Wang, Marianne Hvid, Ann Colleen Nielsen, Christian Møller Pedersen, Jan-Henrik Winsløv, Charlotte Langhoff, Charlotte Mühlmann, Merete Nordentoft
Journal: The Lancet Psychiatry (2015)
Spontaneous Bacterial Peritonitis in Asymptomatic Outpatients With Cirrhotic Ascites
Authors: Luke T. Evans, Ray W. Kim, John J. Poterucha, Patrick S. Kamath
Journal: Hepatology (2003)

The prevalence and natural history of spontaneous bacterial peritonitis in asymptomatic patients with ascites secondary to cirrhosis is unknown. From a prospectively recorded database, we reviewed the clinical and laboratory features of all outpatients with cirrhotic ascites undergoing paracentesis between July 1994 and December 2000. The prevalence of spontaneous bacterial peritonitis in the population of 427 cirrhotic outpatients as defined by neutrocytic ascites (absolute neutrophil count >or=250 cells/mm(3)) was 3.5%. Of the 15 patients with neutrocytic ascites, 6 were culture positive (1.4%) and 9 culture negative (2.1%). Eight other patients (1.9%) had bacterascites. The organisms cultured from ascitic fluid in these asymptomatic patients with culture positive neutrocytic ascites and bacterascites were predominantly gram positive. No patient developed hepatorenal syndrome, and 1-year survival of 67% was better than historical data from hospitalized patients with spontaneous bacterial peritonitis. Moreover, patients who did not receive antibiotics for neutrocytic ascites fared no worse than patients who did receive antibiotics. In conclusion, spontaneous bacterial peritonitis in outpatients with cirrhotic ascites is less frequent, occurs in patients with less advanced liver disease, and may have a better outcome than its counterpart in hospitalized patients. In addition, the organisms cultured from ascitic fluid in outpatients are predominantly gram positive. A reassessment of diagnostic criteria for spontaneous bacterial peritonitis in outpatients may be required.
Familial Incidence of Sialectasis
Authors: M. Smith
Journal: BMJ (1953)

Familial Incidence of SialectasisCases of recurrent swelling of a salivary gland associated with characteristic x-ray appearances, and due to causes other than calculus, are seen from time to time.Such cases are described in detail in the literature, but there is sparse reference to any familial tendency, so that the occurrence of the condition in three generations of a family, all treated at Southend General Hospital; is of some interest.
A CASE OF COLON BACILLUS SEPTICEMIA.
Authors: DELANCEY ROCHESTER
Journal: JAMA (1907)

Nov. 2, 1905, Dr. G. W. Wende, Buffalo, referred to me a man with the following history, whom he had been treating for syphilis: <h3>Patient.</h3> —I. A. K., jeweler, single, aged 38, American, with a good family history. <h3>Personal History.</h3> —The man had had measles several times, typhoid in 1892 and diphtheria in 1896 and 1897. In 1888 he had a chancre, and in 1903 syphilitic rhinitis of mild type. For this he has been under treatment. While under my care, he was seen in consultation by Drs. Conrad Diehl, Chas. G. Stockton, G. W. Wende and Nelson G. Russell. Three weeks before consulting me he had had a severe wetting and had taken cold. A week later began to have night sweats, which continued nearly every night. Sweats occurred early in the night. The night before I saw him, he had had two sweats-one early in the night, the
Dimethylfumarate inhibits nuclear binding of nuclear factor ?B but not of nuclear factor of activated T cells and CCAAT/enhancer binding protein ? in activated human T cells
Authors: S. Gerdes, K. Shakery, U. Mrowietz
Journal: British Journal of Dermatology (2007)

Psoriasis is a chronic inflammatory skin disorder in which T-cell-mediated immune responses are thought to play a prominent role. Fumaric acid esters (FAEs) have proved to be an effective systemic treatment for psoriasis. The FAE dimethylfumarate (DMF) strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells. Additionally, it has been demonstrated that the nuclear translocation of the activated transcription factor nuclear factor kappaB (NF-kappaB) is inhibited in human endothelial cells and fibroblasts activated with tumour necrosis factor-alpha. The NF-kappaB pathway plays a major role in regulating inflammatory cytokine production as well as in cell differentiation and apoptosis. T-cell survival is also dependent on the activation of NF-kappaB and it has been demonstrated in vitro that DMF is an inducer of apoptosis in human T cells. The influence of FAEs on the expression of nuclear transcription factors in T cells has not yet been investigated.The effects of DMF and its main metabolite, methylhydrogenfumarate (MHF), were assessed on the nuclear binding of NF-kappaB, nuclear factor of activated T cells (NF-AT) and CCAAT/enhancer binding protein beta (C/EBPbeta) in purified human T cells.To examine the effect of DMF and MHF on the nuclear binding of NF-kappaB, NF-AT and C/EBPbeta in human T cells and fibroblasts, an enzyme-linked immunosorbent assay (ELISA) was used. The binding activity of these transcription factors was measured by its absorbance in an ELISA plate reader at 450 nm. Conspicuous results were confirmed by performing electrophoretic mobility shift assays.DMF inhibited nuclear binding of NF-kappaB1, but not of NF-AT or C/EBPbeta, in purified human T cells. No effect of MHF on any of these transcription factors could be seen. To verify our results, we used the same assay to show the inhibitory effect on the nuclear binding of NF-kappaB1 in human fibroblasts (as previously published).The results of this study provide evidence for a specific effect of DMF on NF-kappaB. The data support previous results where NF-kappaB-dependent mediators and surface molecules were suppressed by DMF, but not those activated by other nuclear transcription factors.
Krukenberg Tumor and Lung Metastases From Colon Carcinoma Diagnosed With F-18 FDG PET
Authors: PAUL J. BOHDIEWICZ, JACK E. JUNI, DEAN BALL, HOWARD DWORKIN
Journal: Clinical Nuclear Medicine (1995)

The authors report a case of a patient with postsurgical colorectal carcinoma and metastatic disease to the ovaries (Krukenberg tumor), the lung, and the liver first revealed by F-18 FDG PET imaging. The value of PET in a patient with an unexplained rising CEA is cited.
Sex Disparities in the Quality of Diabetes Care: Biological and Cultural Factors May Play a Different Role for Different Outcomes
Authors: Maria Chiara Rossi, Maria Rosaria Cristofaro, Sandro Gentile, Giuseppe Lucisano, Valeria Manicardi, Maria Franca Mulas, Angela Napoli, Antonio Nicolucci, Fabio Pellegrini, Concetta Suraci, Carlo Giorda
Journal: Diabetes Care (2013)

To investigate the quality of type 2 diabetes care according to sex.Clinical data collected during the year 2009 were extracted from electronic medical records; quality-of-care indicators were evaluated. Multilevel logistic regression analysis was applied to estimate the likelihood of women versus men to be monitored for selected parameters, to reach clinical outcomes, and to be treated with specific classes of drugs. The intercenter variability in the proportion of men and women achieving the targets was also investigated.Overall, 415,294 patients from 236 diabetes outpatient centers were evaluated, of whom 188,125 (45.3%) were women and 227,169 (54.7%) were men. Women were 14% more likely than men to have HbA1c>9.0% in spite of insulin treatment (odds ratio 1.14 [95% CI 1.10-1.17]), 42% more likely to have LDL cholesterol (LDL-C)≥130 mg/dL (1.42 [1.38-1.46]) in spite of lipid-lowering treatment, and 50% more likely to have BMI≥30 kg/m2 (1.50 [1.50-1.54]). Women were less likely to be monitored for foot and eye complications. In 99% of centers, the percentage of men reaching the LDL-C target was higher than in women, the proportion of patients reaching the HbA1c target was in favor of men in 80% of the centers, and no differences emerged for blood pressure.Women show a poorer quality of diabetes care than men. The attainment of the LDL-C target seems to be mainly related to pathophysiological factors, whereas patient and physician attitudes can play an important role in other process measures and outcomes.
A TRIAL OF AMOPYKOQUIN IN THE TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS.
Authors: ANNE MAGUIRE
Journal: British Journal of Dermatology (1964)

Journal Article A TRIAL OF AMOPYKOQUIN IN THE TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS. Get access ANNE MAGUIRE, M.B., M.R.C.P. ANNE MAGUIRE, M.B., M.R.C.P. Senior Registrar, Department of Dermatology, University College Hospital, Gower St., London, W.C.I Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 4, 1 April 1964, Pages 191–195, https://doi.org/10.1111/j.1365-2133.1964.tb14505.x Published: 01 April 1964
Polyclonal immunoglobulin secretion in patients with common variable immunodeficiency using monoclonal B cell differentiation factors.
Authors: L Mayer, S M Fu, C Cunningham-Rundles, H G Kunkel
Journal: Journal of Clinical Investigation (1984)

B cells from 25 patients with common variable immunodeficiency (CVI) were tested for their ability to differentiate under the influence of B cell differentiation factors (BCDF), derived from T cell hybridomas or T cell clones. 11 patients generated Ig plaque-forming cells in the range comparable to that of normal controls with supernatant from the T cell hybrid MOP 1L. With various hybrid or clone supernatants, differing response patterns emerged. Four patients who failed to respond to MOP 1L responded to T cell clone supernatant RAC. Another who failed to respond to both MOP 1L and RAC responded to T cell hybrid supernatant MTP 7. These results indicate that these supernatants contain different BCDFs and suggest heterogeneity in the differentiation states of B cells in CVI. In addition, three patients demonstrated exaggerated responses to BCDF, and evidence was obtained from B cells of these patients for increased BCDF receptor density. Thus, the accumulated evidence indicates that T cell defects may be a primary pathogenetic mechanism in common variable immunodeficiency, and purified BCDF may be of therapeutic value.
Review of<i>Wrong Medicine: Doctors, Patients, and Futile Treatment, Second Edition</i>by Lawrence J. Schneiderman and Nancy S. Jecker
Authors: Thaddeus Mason Pope
Journal: The American Journal of Bioethics (2012)

When may physicians refuse to provide medical interventions that might prolong the patient's life? When should they refuse? When must they? Such questions of medical futility remain as much a subje...
RED CELL AND PLASMA VOLUMES (CIRCULATING AND TOTAL) AS DETERMINED BY RADIO IRON AND BY DYE
Authors: P. F. Hahn, J. F. Ross, W. F. Bale, W. M. Balfour, G. H. Whipple
Journal: The Journal of Experimental Medicine (1942)

1. Application of the principles of hydrodynamics to the problem of blood flow and blood volume indicates that the calculation of blood volume and cell volume from the venous hematocrit and plasma volume (as determined by the dye method) is subject to considerable error. 2. This conclusion is borne out by determinations of total cell volume by viviperfusion and with the use of radioactive iron tagged erythrocytes, which have shown the erythrocyte volume to be only 70 to 75 per cent of the volume indicated by the previously mentioned calculations. 3. The average hematocrit of the entire vascular system is considerably lower than the hematocrit of the large vessels, and the cell-plasma ratio of the smaller vessels is still less. 4. In the dog there are no considerable stores of immobilized erythrocytes, and the total erythrocyte volume and circulating erythrocyte volume are identical. 5. The "rapidly circulating blood volume" can be determined by dividing the erythrocyte volume by the venous hematocrit, and is found to be considerably less than the total blood volume. 6. The concept of the "rapidly circulating plasma volume" is introduced, and it is found to be approximately 80 per cent of the total plasma volume. 7. The volume of plasma in the peripheral, cell free, sluggishly moving plasma films, plus that contained in small vessels in which no red cells are present, is also determined and found to be approximately 20 per cent of the entire plasma volume. 8. The existence and magnitude of these fractions of the blood plasma volume should receive consideration in studies of blood flow and blood volume.
effects of coronary stenting on vessel patency and long-term clinical outcome after percutaneous coronary revascularization in diabetic patients
Authors: Eric Van Belle, Marc Périé, David Braune, Akram Chmaït, Thibaud Meurice, Kaveh Abolmaali, Eugène P. McFadden, Christophe Bauters, Jean-Marc Lablanche, Michel E. Bertrand
Journal: Journal of the American College of Cardiology (2002)
Reply to R.G. Margolese
Authors: Rachel Rabinovitch, Brian Kavanagh
Journal: Journal of Clinical Oncology (2009)

We thank Margolese 1 for his interest in our recent editorial, 2 and we appreciate his valuable contributions as a senior investigator in much of the National Surgical Adjuvant Breast and Bowel Project work discussed.We agree that randomized clinical trials offer the purest test of any clinical hypothesis.However, it is sometimes difficult, not to mention expensive, to successfully execute trials large enough to detect small, yet clinically meaningful, differences.Meta-analyses can be helpful in this regard.If we put aside meta-analyses, we can still look to the 20-year reported results of National Surgical Adjuvant Breast and Bowel Project B-06, 3 which documented that lumpectomy followed by breast irradiation was associated with a significant decrease in deaths due to breast cancer relative to lumpectomy alone (hazard ratio, 0.82; P ϭ .04).We feel this provides support for a breast cancer model that includes a pathway where local recurrence can ultimately lead to distant disease and death in a subset of patients.This pathway lies alongside one where local recurrence may be an early manifestation of pre-existing aggressive systemic disease.The many divergent ways that clinical trial results can be interpreted within the oncology community points to the importance of continuing this research effort and deriving data which refines and focuses our understanding of the complex interactions between breast oncology and its therapies.
Dapsone-induced haemolytic anaemia
Authors: JOHN H. S. PETTIT
Journal: British Journal of Dermatology (1980)

Journal Article Dapsone‐induced haemolytic anaemia Get access JOHN H. S. PETTIT JOHN H. S. PETTIT Room 303, China Insurance Building, 174 Jalan Tuanku Abdul Rahman, Kuala Lumpur, Malaysia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 102, Issue 3, 1 March 1980, Pages 365–366, https://doi.org/10.1111/j.1365-2133.1980.tb08157.x Published: 01 March 1980
An ultrasonic analysis of the comparative efficiency of various cardiotomy reservoirs and micropore blood filters.
Authors: D T Pearson, B G Watson, P S Waterhouse
Journal: Thorax (1978)

The ability of 12 commercially available cardiotomy reservoirs to remove bubbles from aspirated blood was investigated by means of a simulated cardiopulmonary bypass circuit and an ultrasonic microbubble detector. Performance varied considerably. The number of gaseous microemboli remaining after passage of blood through the reservoir was reduced by (a) holding the blood in the reservoir, (b) reducing the volume of air mixed with the aspirated blood, and (c) using a reservoir that did not induce turbulence and that contained integral micropore filtration material. Further micropore filtration of the blood after passage through the cardiotomy reservoir was beneficial, and significantly more bubbles were extracted when the microfilter was sited below the reservoir than when it was placed in the arterial line.
Does VA Health Care Measure up?
Authors: Stephan D. Fihn
Journal: New England Journal of Medicine (2000)

Nearly 25 years ago, a congressionally mandated study found that many components of the health care system of the Veterans Administration (now the Department of Veterans Affairs, or VA) were inefficient and often poor in quality.1 A blue-ribbon panel concluded that the system's principal resource, a loosely connected network of acute care hospitals, was poorly matched to the needs of the mostly elderly and chronically ill veterans it was designed to serve. The panel expressed little optimism about the system's capacity to improve and advised allowing the private sector to take over most of the VA's responsibilities. This recommendation was . . .
Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
Authors: Thomas Lehner, Yufei Wang, Martin Cranage, Lesley A. Bergmeier, Elaine Mitchell, Louisa Tao, Graham Hall, Mike Dennis, Nicola Cook, Roger Brookes, Linda Klavinskis, Ian Jones, Carl Doyle, Robert Ward
Journal: Nature Medicine (1996)
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Authors: Douglas A. Kuperman, Xiaozhu Huang, Laura L. Koth, Grace H. Chang, Gregory M. Dolganov, Zhou Zhu, Jack A. Elias, Dean Sheppard, David J. Erle
Journal: Nature Medicine (2002)
Fatal Marrow Aplasia During Chlorpropamide Therapy
Authors: L. L. R. White
Journal: BMJ (1962)

not uncommon in human populations.Further research seems desirable on the copper contents of human dietaries, and on the intricate interrelationships between the absorption and metabolism of copper, iron, and calcium.SUMMARY Young rats fed on a diet of raw minced beefsteak developed signs of copper deficiency as evidenced by hypochromotrichia, slight anaemia, and a slight reduc- tion in the rate of weight increase.The deficiency could be prevented by the addition to the meat of copper sulphate or of impure ferrous carbonate containing copper.Chemical analyses showed that the meat contained the expected amounts of copper.A defect in its absorption, probably due to the high phosphate content of the meat, therefore seemed probable.In adult rats hypochromotrichia could be prevented, and in young rats partially prevented, by the addition of calcium carbonate to the diet.The calcium carbonate contained only traces of copper, and presumably acted by counteracting the high intake of phosphate.
Sustained complete hematologic remission after administration of the tyrosine kinase inhibitor imatinib mesylate in a patient with refractory, secondary AML
Authors: Thomas Kindler, Frank Breitenbuecher, Andreas Marx, Georg Hess, Harald Gschaidmeier, Heinold Gamm, Charles J. Kirkpatrick, Christoph Huber, Thomas Fischer
Journal: Blood (2003)
Body Awareness and Personality
Authors: J. Vinck
Journal: Psychotherapy and Psychosomatics (1979)

The relation between personality characteristics and body awareness, defined as the attention paid to different body zones and measured by means of the Fisher Body Focus Questionnaire, is examined in two ways in groups of medical and dental students: (1) Our results replicate fairly well the relation, reported by Fisher, between back and head awareness and anal characteristics. (2) Exploration of the relations between body awareness and descriptive personality characteristics (neuroticism, extraversion, etc.) reveals differences between sexes: in women back awareness correlates positively with neuroticism and negatively with extraversion; in men higher awareness of the right side of the body is related to lower neuroticism but also to higher scores for test-taking attitude and social desirability. Some implications for our understanding of the position of the body and for psychosomatic research are briefly discussed.
Surgical Considerations in Older Adults With Cancer
Authors: Beatriz Korc-Grodzicki, Robert J. Downey, Armin Shahrokni, T. Peter Kingham, Snehal G. Patel, Riccardo A. Audisio
Journal: Journal of Clinical Oncology (2014)

The aging of the population is a real concern for surgical oncologists, who are increasingly being asked to treat patients who would not have been considered for surgery in the past. In many cases, decisions are made with relatively little evidence, most of which was derived from trials in which older age was a limiting factor for recruitment.This review focuses on risk assessment and perioperative management. It describes the relationship between age and outcomes for colon, lung, hepatobiliary, and head and neck cancer, which are predominantly diseases of the elderly and are a major cause of morbidity and mortality.Effective surgery requires safe performance as well as reasonable postoperative life expectancy and maintenance of quality of life. Treatment decisions for potentially vulnerable elderly patients should take into account data obtained from the evaluation of geriatric syndromes, such as frailty, functional and cognitive limitations, malnutrition, comorbidities, and polypharmacy, as well as social support. Postoperative care should include prevention and treatment of complications seen more frequently in the elderly, including postoperative delirium, functional decline, and the need for institutionalization.Surgery remains the best modality for treatment of solid tumors, and chronologic age alone should not be a determinant for treatment decisions. With adequate perioperative risk stratification, functional assessment, and oncologic prognostication, elderly patients with cancer can do as well in terms of morbidity and mortality as their younger counterparts. If surgery is determined to be the appropriate treatment modality, patients should not be denied this option because of their age.