tbuckley/cabot-search huggingface dataset:
CABG and Medical Therapy Perform Equally Well in Patients With Heart Failure
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Human Agenda
Authors: W. C. Ellerbroek
Journal: JAMA (1973)

The author, a psychiatrist and psychoanalyst, has invested much in this volume. "The world, past, present, and future, as seen by the writer" would be a suitable subtitle, but often he seems to say "This is the way it is" instead of "This is the way<i>/</i>see it." It is an intimate book, a personal book, and cannot be reviewed or criticized without revealing the biases, attitudes, and opinions of reviewer and author. The initial section is a nicely done summary of evolution as held until recent years, and includes man's conceptual developments as part of the evolutionary process. The author gives more than a hundred pages to his comments on current wild and weird speculations about birth, death, the brain, cloning, cryonic immortality, gene manipulations, the redundancy of the male in a parthenogenetic society, and such matters. The second section, "Love, Work, and Play Revisited," is a superior attempt
Open-label study of the efficacy and safety of topical treatment with TDT 067 (terbinafine in Transfersome®) in patients with onychomycosis
Authors: R. Dominicus, C. Weidner, H. Tate, H.-A. Kroon
Journal: British Journal of Dermatology (2011)

Journal Article Open‐label study of the efficacy and safety of topical treatment with TDT 067 (terbinafine in Transfersome®) in patients with onychomycosis Get access R. Dominicus, R. Dominicus Praxisklinik und Gemeinschaftspraxis, Vollenstrasse 8, 48249 Dülmen, Germany Ralf Dominicus. E‐mail: praxis@hautzentrum‐duelmen.de Search for other works by this author on: Oxford Academic Google Scholar C. Weidner, C. Weidner X‐pert Med GmbH Jena, Jena, Germany Search for other works by this author on: Oxford Academic Google Scholar H. Tate, H. Tate Helen Tate Statistics Ltd, Saffron Walden, U.K Search for other works by this author on: Oxford Academic Google Scholar H.‐A. Kroon H.‐A. Kroon Celtic Pharma Development Services America Inc., New York, NY, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 166, Issue 6, 1 June 2012, Pages 1360–1362, https://doi.org/10.1111/j.1365-2133.2011.10766.x Published: 01 June 2012
Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.
Authors: S Bogen, J Pak, M Garifallou, X Deng, W A Muller
Journal: The Journal of Experimental Medicine (1994)

A murine model of peritonitis was used to test the role of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) in acute inflammation. A monoclonal antibody (mAb) specific for murine PECAM-1 injected intravenously 4 h before the intraperitoneal injection of thioglycollate broth blocked leukocyte emigration into the peritoneal cavity for up to 48 h. This block was particularly evident for neutrophils. Control mAb, including one that bound to murine CD18 without blocking its function, failed to block emigration when used at the same or higher concentrations. The decreased emigration seen with the anti-PECAM-1 antibody was not due to neutropenia or neutrophil sequestration in the lung, spleen, or other organs; peripheral blood leukocyte counts were not diminished in these mice. In the mesenteric venules of the mice treated with anti-PECAM-1 mAb, leukocytes were frequently seen in association with the luminal surface of the vessel, but did not appear to emigrate. Thus, the requirement for PECAM-1 in the transendothelial migration of leukocytes previously seen in an in vitro model holds true in this in vivo model of acute inflammation.
Dual binding capacity of mucosal immunoblasts to mucosal and synovial endothelium in humans: dissection of the molecular mechanisms.
Authors: M Salmi, D P Andrew, E C Butcher, S Jalkanen
Journal: The Journal of Experimental Medicine (1995)

Lymphocytes continuously migrate throughout the body in search of antigens. Virgin lymphocytes recirculate freely between the blood and different lymphatic organs, whereas immunoblasts extravasate preferentially into sites similar to those where they initially responded to antigen. Tissue-specific extravasation of lymphocytes is largely controlled by distinct lymphocyte surface receptors that mediate lymphocyte binding to high endothelial venules (HEV). In the present study, the molecular mechanisms determining the specificity of human mucosal (lamina propria) lymphocyte binding to different endothelial recognition systems were analyzed. Mucosal immunoblasts adhered five times better than small mucosal lymphocytes to mucosal HEV. Importantly, mucosal immunoblasts also bound to synovial HEV almost as efficiently as to mucosal HEV, but they did not adhere to peripheral lymph node HEV. To study the impact of different homing-associated molecules in this dual endothelial binding, we used a gut-derived T cell line and freshly isolated mucosal immunoblasts. Both cell types expressed integrins alpha 4, beta 1, beta 7, and lymphocyte function associated antigen 1 (LFA-1), and were CD44 positive, but practically L-selectin negative. Binding of mucosal immunoblasts to mucosal HEV was almost completely abolished by pretreatment with anti-beta 7 monoclonal antibodies, but it was independent of alpha 4/beta 1 function. In contrast, alpha 4/beta 1 partially mediated immunoblast adherence to synovial HEV, whereas alpha 4/beta 7 had only a minor role in adherence of blasts at this site. CD44 and LFA-1 contributed to HEV-binding both in mucosa and synovium. Taken together, this is the first report that demonstrates a critical role for alpha 4/beta 7 in the binding of gut lymphocytes to mucosal venules in humans. Moreover, a hitherto unknown interaction between mucosal effector cells and synovial endothelial cells was shown to be only partially mediated by the currently known homing receptors. The dual endothelial binding capacity of mucosal blasts may help to explain the pathogenesis of reactive arthritis not uncommonly associated with inflammatory and infectious bowel disease.
INJURIES PRODUCED BY STARCH
Authors: I. A. ABT
Journal: JAMA (1913)

The Mehlnahrschaden of the Germans, or the  injuries, have been extensively discussed in the German literature, especially in the writings of Czerny and Keller, and the Breslau school, and elaborated by the studies of Risel and Rietschel. To the genius of Czerny and Keller we are indebted for the conceptions of injuries to the organism produced by fat and starch and overfeeding with milk. These studies gave a great impetus to investigations of injurious effects produced by the component parts of milk. Thus, the ill-effects from excessive feeding of sugar, salts, starches, proteins and fats have been extensively studied.  In this brief clinical report I desire to review the work of the German authors on the starch injuries and to recite personal experiences. I feel it necessary to acknowledge that no original contribution is being offered, and feel that sufficient excuse for the publication of this report lies in
Immunosuppression by D-penicillamine in vitro. Inhibition of human T lymphocyte proliferation by copper- or ceruloplasmin-dependent generation of hydrogen peroxide and protection by monocytes.
Authors: P E Lipsky
Journal: Journal of Clinical Investigation (1984)

It has been suggested that D-penicillamine is active in rheumatoid arthritis because of its capacity to function as a selective inhibitor of T lymphocyte function. The basis for the immunosuppressive action of this drug as well as mechanisms whereby the effect of D-penicillamine could be modified by elements of rheumatoid synovial tissue were examined. As previously reported, D-penicillamine, in the presence of copper ions markedly inhibited mitogen-induced human T lymphocyte DNA synthesis. Since the vast majority of copper in the body exists as an integral part of the ceruloplasmin molecule, the capacity of this cuproprotein to augment D-penicillamine-mediated inhibition of T cell function was examined. The requirement for copper ions could be entirely replaced by purified ceruloplasmin, which had been depleted of nonspecifically bound copper by passage over Chelex-100 columns. The mechanism by which D-penicillamine in the presence of either copper ions or ceruloplasmin caused inhibition of T lymphocyte responsiveness was examined. Partial protection from this inhibitory effect was accomplished by sodium borohydride. While superoxide dismutase had no protective effect, catalase was found to protect lymphocyte responsiveness totally from the inhibitory action of D-penicillamine and either copper ions or ceruloplasmin. Similarly, horseradish peroxidase and myeloperoxidase also protected responsiveness from these inhibitors while boiled catalase was without effect. These results indicate that inhibition of T lymphocyte responsiveness resulted from the generation of hydrogen peroxide. Since a number of cells likely to be present at chronic inflammatory sites, such as mononuclear phagocytes, contain enzymatic mechanisms to degrade hydrogen peroxide, the modulatory influence of these cells on the inhibition of T cell function caused by D-penicillamine and copper was examined. Monocytes, whose function was not suppressed by D-penicillamine and copper, were found to protect T lymphocyte responsiveness from the inhibitory effects of either the mixture of D-penicillamine and CuSO4 or of hydrogen peroxide. By contrast, endothelial cells, fibroblasts, or cells obtained from enzyme-digested noninflamed synovium could not protect T cells from the inhibitory effects of D-penicillamine and copper. Protection of T cells was afforded by means of a heat labile, azide-sensitive soluble factor present in lysates of human monocytes. These results indicate that the mechanism whereby D-penicillamine in the presence of copper or ceruloplasmin inhibits T lymphocyte responsiveness involves the generation of hydrogen peroxide and that other neighboring cells likely to be found w
300 DERIVATION OF A NORMATIVE UK DATABASE FOR THE PSYCHOMETRIC HEPATIC ENCEPHALOPATHY SCORE (PHES): CONFOUNDING EFFECT OF ETHNICITY AND TEST SCORING
Authors: M.E. Marks, C.D. Jackson, S. Montagnese, C.W. Jenkins, M. Head, R.W. Morris, M.Y. Morgan
Journal: Journal of Hepatology (2008)
A New Operation for Slipping Patella
Authors: ROBERT SOUTTER
Journal: New England Journal of Medicine (1933)

An extreme case of slipping patella was observed in the Children's Hospital, in a girl aged about 9 years, with a double congenital dislocation of the patella gradually increasing in laxity. The ordinary methods of treatment did not seem appropriate or adequate. The left patella constantly and without warning would dislocate over the external condyle, causing the child to fall without warning. The action of the quadriceps was uncertain, and walking was not sure.  The child was healthy and normal. Examination of the legs showed good muscle tone and normal range of motion of the hips, knees and feet. Everything was normal except for the knees. One was impressed with four things: (1) the looseness of the patellar ligament and all the tissues to the inner side of the patella; (2)the ease with which the patella could be placed over to the outer side, so far over that the internal
Generalized Essential Telangiectasia
Authors: John D. McGrae
Journal: JAMA (1963)

Cutaneous patterns of acquired generalized telangiectasia sometimes exist without associated systemic disease. They have been recognized heretofore and have been called  telangiectasia. Analysis of the clinical features in 13 cases reveals that the disease is much more common among women; the average age at onset is 38 years; and the development of the lesions is gradual. The lesions persist indefinitely throughout many years without effect on the general health of the patient. The clinical patterns may be diffuse or localized, macular, plaque-like or retiform, and discrete or confluent. Microscopic study reveals thin-walled ectatic vessels in the upper part of the corium in which alkaline phosphatase activity is not demonstrable. In contrast, the telangiectatic vessels of dermatomyositis do exhibit alkaline phosphatase activity. The evidence suggests that essential telangiectasia can be differentiated histochemically from symptomatic telangiectasia on the basis of alkaline phosphatase activity.
AB0430 What is the role of ambulatory blood pressure monitoring in sle?
Authors: E. Er, A. Akdogan, L. Kilic, U. Canpolat, B. Kaya, O. Karadag, U. Kalyoncu, S. A. Bilgen, S. Kiraz, M. Hayran, I. Ertenli
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Patients with systemic lupus erythematosus (SLE) are at increased risk for the development of atherosclerotic cardiovascular disease (CVD). Hypertension (HT) which is frequently seen in SLE is a major risk factor for CVD. Ambulatory blood pressure monitoring is useful for both the diagnosis and the evaluation of HT. <h3>Objectives</h3> This study was conducted to compare the results of office, home and ambulatory blood pressure monitoring measurements in SLE patients. <h3>Methods</h3> We studied 86 SLE patients. Office, home and 24-hour ambulatory blood pressure measurements were performed in all patients. Results of the blood pressure measurements were evaluated according to current guidelines (1). Disease activity in SLE patients was defined by using the Safety of Estrogens in Lupus Erythematosus National Assessment-Sistemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) scores. <h3>Results</h3> The mean age of the SLE patients (90.7% female) was 43±12 years. Of them 34 (39.5%) patients had a history of HT. In SLE patients with HT blood pressure control was not achieved in 12 (35.3%)patients with office measurements, in 16 (47.1%)patients with home measurements and in 13 (38.2%)patients with 24-hour ambulatory measurements. Among patients with no prior history of HT, there were 7 (13.5%)new diagnoses of hypertension by office measurements, 8 (15.4%)new diagnoses by home measurements and 9 (17.3%)new diagnoses by ambulatory monitoring. In the group with no prior history of HT, we observed that the concordance between the office and 24-hour ambulatory measurements was extremely low (Kappa: 0.116, <i>p</i>= 0.40). The concordance between self measurements at home and ambulatory measurements was moderate but less than ideally expected (Kappa: 0.504, p&lt; 0.001). The results for patients with a history of HT were similar with Kappa values of 0.178 and 0.476 when comparing ambulatory measurements with office and home measurements, respectively. The SELENA-SLEDAI values for the concordant and discordant pairs were similar for both home versus ambulatory and clinic versus ambulatory comparisons (both <i>p</i>&gt; 0.05, Mann-Whitney U test). <h3>Conclusions</h3> The concordance between the blood pressure evaluation methods is low in SLE patients. 24-hour ambulatory blood pressure monitoring should be the preferred method for accurate evaluation of HT in patients with high risk for cardiovascular diseases. <h3>References</h3> European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): the Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice.2012;19(4):585-667. <h3>Disclosure of Interest</h3> None Declared
Novel diagnostic methods for early-stage squamous cell carcinoma of the anal canal successfully resected by endoscopic submucosal dissection
Authors: Y. Chou, Y. Saito, T. Matsuda, T. Nakajima, Y. Mashimo, Y. Moriya, T. Shimoda
Journal: Endoscopy (2009)

Although anal canal squamous cell carcinoma (ACSCC) is quite rare, it can be recognized clearly using iodine staining [1]. Early-stage esophageal squamous cell carcinoma (SCC) has recently been diagnosed using both narrow-band imaging (NBI) [2] and autofluorescence imaging (AFI) [3]. Here we report on the first case of early-stage ACSCC diagnosed by NBI and AFI and treated successfully by endoscopic submucosal dissection (ESD).
367. Lentivirus Pseudotyped with Envelope Proteins F and HN from Sendai Virus Transduce Airway Epithelium Efficiency and Persistently
Authors: Uta Griesenbach, Katsuyuki Mitomo, Makoto Inoue, Lucinda Somerton, Raymond Farley, Charanjit Singh, Toshiaki Tabata, Yasuji Ueda, Satoshi Fujikawa, Kentaro Washizawa, Mamoru Hasegawa, Eric W.F.W. Alton
Journal: Molecular Therapy (2006)

We have previously shown that recombinant Sendai-virus (SeV) vector transduces airway epithelium efficiently via the apical membrane. This is in part due to cholesterol and sialic acid in the apical membrane which are respectively utilized by the SeV fusion (F) and hemagluttinin-neuraminidase (HN) proteins for receptor- mediated cell attachment, as well as the capacity of SeV to penetrate mucus efficiently. In contrast to SeV, which leads to transient gene expression, integrating lentiviral vectors have the theoretical advantage of persistent expression for the life-time of the cell, and ifstem cell integration should occur, for the lifetime of the animal. We have recently succeeded in generating a F/HN-pseudotyped Simian immunodeficiency virus (SiVagm) vector at high enough titre for in vivo application (>109 transduction units (TU)/ml). A F/HN-SiV- GFP vector (4x108 TU/mouse in 100 ml) was slowly perfused (over 75 min) onto the nasal epithelium of C57Bl/6 mice and transduced airway epithelial cells efficiently, via the apical membrane without the need for chemical pre-conditioning. We choose transduction of the nasal epithelium as proof-of-principle because we aim to extend these studies into CF knockout mice (only the nasal epithelium shows the CF defect in this model). We previously reported detection of GFP expression at 1, 20, 30, 90 days (n=3 mice/group) and 220 days (n=1) after transduction. Here, we further extended these studies to both include higher n numbers and, to identify transduced cells. Importantly, 180 days after transduction 8 out of 10 (6 histological sections 1 mm apart/mouse) mice still expressed GFP. Preliminary experiments on a single animal also showed persistent expression 360 days after transduction, and further animals transduced 270 and 360 days ago, are currently being analysed (n=12–15/group). This duration of gene expression is far longer than the predicted life-span of airway epithelial cells of approximately 100 days. One explanation is that F/HN-SiV vector has transduced progenitor or stem cells in the mouse nose. Morphological analysis showed that GFP positive cells were ciliated airway epithelial cells, and cells being in the olfactory epithelium which based on morphological criteria, appeared to be sensory neuronal cells. Some authors are employed by DNAVEC Corporation.
Therapy for Thrombotic Thrombocytopenic Purpura
Authors: CONRAD C. SIMPFENDORFER
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 May 1977Therapy for Thrombotic Thrombocytopenic PurpuraCONRAD C. SIMPFENDORFER, M.D.CONRAD C. SIMPFENDORFER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-5-657_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Having read the editorial by Amorosi and Karpatkin (Ann Intern Med 86:102-106, 1977), I wish to report the case of a patient with thrombotic thrombocytopenic purpura in which antiplatelet agents played a major role in achieving a remission.A 48-year-old woman was admitted to St. Luke's Hospital on 19 September 1974 with a 2-week history of progressive weakness and malaise.At admission she appeared confused and restless. Laboratory findings included hemoglobin, 6.9 g/dl; hematocrit, 22%; leukocyte count, 24 600/mm3; platelets, 105 000/mm3; Coombs' test, negative; and prothrombin time, 11/11.8 sec. Urine and two blood cultures grew Escherichia...References1. AMOROSI E and ULTMANN J: Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature. Medicine (Baltimore) 45:139-159, 1966 CrossrefGoogle Scholar2. JAMES T and MONTO R: Pathology of the cardiac conduction system in thrombotic thrombocytopenic purpura. Ann Intern Med 65:37-43, 1966 LinkGoogle Scholar3. GIROMINI M, BOUVIER C, and DAMI R: Effect of dipyridamole and aspirin in thrombotic microangiopathy. Br Med J 1:545-546, 1972 CrossrefMedlineGoogle Scholar1. AMOROSI E and KARPATKIN S: Antiplatelet treatment of thrombotic thrombocytopenic purpura. Ann Intern Med 86:102-106, 1977 LinkGoogle Scholar2. AMOROSI E and ULTMANN J: Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature. Medicine (Baltimore) 45:139-159, 1966 CrossrefGoogle Scholar3. ZACHARSKI L, LASTED O, and BLOCK J: Thrombotic thrombocytopenic purpura in a previously splenectomized patient. Am J Med 60:1061-1063, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CONRAD C. SIMPFENDORFER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThrombotic Thrombocytopenic Purpura in Older PatientsCase Report Thrombotic thrombocytopenic purpura in a splenectomized patient with Hodgkin’s disease 1 May 1977Volume 86, Issue 5Page: 657-659KeywordsAntiplatelet therapyBloodHematocritHemoglobinPlateletsProthrombin timeResearch laboratoriesThrombotic thrombocytopenic purpuraUrine ePublished: 1 December 2008 Issue Published: 1 May 1977 PDF downloadLoading ...
Frequency of Sexual Dysfunction in “Normal” Couples
Authors: Ellen Frank, Carol Anderson, Debra Rubinstein
Journal: New England Journal of Medicine (1978)

In analyzing the responses of 100 predominantly white, well educated and happily married couples to a self-report questionnaire, this study examined the frequency of sexual problems experienced and the relations of those problems to sexual satisfaction. Although over 80 per cent of the couples reported that their marital and sexual relations were happy and satisfying, 40 per cent of the men reported erectile or ejaculatory dysfunction, and 63 per cent of the women reported arousal or orgasmic dysfunction. In addition, 50 per cent of the men and 77 per cent of the women reported difficulty that was not dysfunctional in nature (e.g., lack of interest or inability to relax). The number of "difficulties" reported was more strongly and consistently related to overall sexual dissatisfaction than the number of "dysfunctions."