Mucopolysaccharides and Atherosclerosis
Authors: BENJAMIN MILLER
Journal: Annals of Internal Medicine (1964)

Editorials1 November 1964Mucopolysaccharides and AtherosclerosisBENJAMIN MILLER, CH.E. M.D.BENJAMIN MILLER, CH.E. M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-982 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"To sum up, we understand by arteriosclerosis a chronic disturbance of the vessels which manifests itself by deposits of the most varied kinds in the vascular walls—." LUDWIG ASCHOFF (1).Until a few decades ago it was still considered permissible to dismiss atherosclerosis and arteriosclerosis as the inevitable partners of the aging process. Today, from pediatric medicine comes one of the most interesting clues to a fuller understanding of the genesis of the arterial lesion. It has been observed in children with Hurler's syndrome (gargoylism) that atherosclerosis is a frequent event. As McKusick (2) writes: "Grossly even in young individuals...References1. ASCHOFF L: Introduction. Arteriosclerosis. Edited by COWDRY, E. V. The Macmillan Co., New York, 1933, p. 8. Google Scholar2. MCKUSICK VA: Heritable Disorders of Connective Tissue, C. V. Mosby Co., St. Louis, 1960, p. 264. Google Scholar3. LINDSAYREILLYGOTHAMSKAHEN SWATJR: Gargoylism. II. Study of pathologic lesions and clinical review of twelve cases. Amer. J. Dis. Child. 76: 239, 1948. CrossrefMedlineGoogle Scholar4. BERENSONGEER GSJC: Heart disease in the Hurler and Marfan syndromes. Arch. Intern. Med. (Chicago) 111: 58, 1963. CrossrefMedlineGoogle Scholar5. SCHWARTZCASLEY-SMITH CJJR: Atherosclerosis and the serum mucoprotein levels of the Australian aborigine. Aust. J. Exp. Biol. Med. Sci. 36: 117, 1958. CrossrefMedlineGoogle Scholar6. MOONRINEHART HDJF: Histogenesis of coronary arteriosclerosis. Circulation 6: 481, 1952. CrossrefMedlineGoogle Scholar7. 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MIASNIKOW AL: Atherosclerosis: Occurrence, Clinical Forms, Therapy. State Publishing House of Medical Literature, Moscow, 1960; English translation sponsored and distributed by National Heart Institute, Bethesda, Md., 1962. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BENJAMIN MILLER, CH.E. M.D.Affiliations: Harrison Department of Surgical Research University of Pennsylvania School of Medicine Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArteriosclerotic Changes within the Diabetic Oral VasculatureIncreased activity of lysosomal enzymes in human atherosclerotic aortasBeta-glucuronidase activity and its variation with pH in human atherosclerotic arteries 1 November 1964Volume 61, Issue 5_Part_1Page: 982-986KeywordsAgingAtherosclerosisChildrenLesions ePublished: 1 December 2008 Issue Published: 1 November 1964 PDF downloadLoading ...