tbuckley/cabot-search huggingface dataset:
Safe Management of Modified Electrotherapy
Authors: John R. Lincoln, Frank S. Broggi
Journal: New England Journal of Medicine (1955)

SCINCE March, 1947, when one of us described the status of electroshock therapy,1 great progress has been made in this field. At the Maine General Hospital this progress has largely been due to the cooperative efforts of the Department of Psychiatry and the Department of Anesthesiology in adopting a modified technic based on the routine use of a muscle relaxant and high concentrations of oxygen. The method has been in use at the hospital for over six years, during which more than 3200 treatments have been administered; it is employed in all patients accepted for treatment, whether they are considered . . .
Mycobacterium avium-intracellulare pleuritis with massive pleural effusion
Authors: Y Okada, Y Ichinose, K Yamaguchi, M Kanazawa, F Yamasawa, T Kawashiro
Journal: European Respiratory Journal (1995)

Atypical mycobacterial infection is seldom accompanied by pleural involvement. We report a very rare case of Mycobacterium avium-intracellulare pleuritis with massive pleural effusion. The patient was a non-immunocompromised 35-year-old Japanese male with insidious onset of fever, chest pain and anorexia. The pleural effusion gradually resolved with empirical antimycobacterial treatment, leaving considerable pleural adhesion and thickening.
Online tests reach the patients other chlamydia tests can't reach
Authors: D. Spurgeon
Journal: BMJ (2011)

Free home tests for chlamydia that are available on the internet show a higher prevalence of infection than family planning clinic surveys. Tests offered on the internet resulted in 10.3% positive results for Chlamydia trachomatis infection among 1171 women who mailed in swabs, whereas the prevalence among women who were screened in US family planning clinics ranged from 3.3% to 5.5%, found a new study.

The study, published in Sexually Transmitted Diseases (2011;38:74-8, doi:10.1097/OLQ.0b013e3182039d7f), offered free, home based chlamydia testing to women aged 14 years or older living in Maryland.

The proportion of positive results from internet tests …
Regional myocardial deoxyglucose uptake following electrical stimulation of canine efferent sympathetic cardiopulmonary nerves
Authors: M G. Trivella, J A. Armour, M. D. Vacche, C. Paoli, R. Porinelli, R. Bellazzini, G. Pelosi, P. G Camici, L. Taddei, G. A Klassen, A. L'Abbate
Journal: Cardiovascular Research (1992)

Objective: The aim was to study the effect of stimulating individual acutely decentralised cardiopulmonary nerves on myocardial uptake of deoxyglucose. Methods: In 17 open chest anaesthetised dogs the efferent axons of individual decentralised cardiopulmonary nerves were stimulated intermittently throughout 1 h while haemo-dynamic variables were measured. Tritiated 2-deoxyglucose was injected intravenously at the beginning of stimulation. Atropine was given when a cardiopulmonary nerve with efferent parasympathetic axons was studied. Distribution of label was detected using a multiwire proportional chamber. It was compared to blood concentration of deoxyglucose to permit quantitative mapping of regional myocardial uptake during the stimulation of each nerve. Results: Neural stimulation of most of sympathetic efferent cardiopulmonary nerves increased deoxyglucose uptake in all myocardial tissue. Uptake was greatest in the left ventricle, less in the right ventricle, and least in the left and right atria. Regional myocardial uptake was also observed following individual cardiopulmonary nerve stimulation. Some nerves caused greater uptake than others. Cardiopulmonary nerves which are known to enhance inotropism when stimulated induced little increase of deoxyglucose uptake, whereas other nerves known to exert little positive inotropic effect induced considerable uptake. There was no correlation between haemodynamic changes and deoxyglucose uptake. Conclusions: It appears that (1) efferent sympathetic axons in one cardiopulmonary nerve can preferentially increase deoxyglucose uptake in specific regions of the myocardium and (2) the mechanisms responsible for enhancement of glucose uptake may differ from those responsible for inotropic responses.
Urinary Incontinence in Older Women
Authors: Huan J. Chang
Journal: JAMA (2010)

Urinary Incontinence in Older WomenU rinary incontinence (involuntary loss of urine) is twice as common in women as in men and affects at least 1 in 3 older women.Urinary incontinence is not a normal result of aging; it is a medical problem that is often curable and should be treated.Urine is stored in the bladder and emptied via a tube called the urethra.During urination, muscles of the bladder wall contract, forcing urine from the bladder into the urethra.Sphincter muscles surrounding the urethra relax, releasing urine from the body.Incontinence occurs if bladder muscles suddenly contract or sphincter muscles are not strong enough to contain urine.The June 2, 2010, issue of JAMA includes an article about incontinence in older women.
Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989–2008)
Authors: Anaadriana Zakarija, Hau C Kwaan, Joel L Moake, Nicholas Bandarenko, Dilip K Pandey, June M McKoy, Paul R Yarnold, Dennis W Raisch, Jeffrey L Winters, Thomas J Raife, John F Cursio, Thanh Ha Luu, Elizabeth A Richey, Matthew J Fisher, Thomas L Ortel, Martin S Tallman, X Long Zheng, Masanori Matsumoto, Yoshihiro Fujimura, Charles L Bennett
Journal: Kidney International (2009)
Rapid diagnosis of falciparum malaria by using the ParaSight F test in travellers returning to the United Kingdom: prospective study
Authors: I M Cropley
Journal: BMJ (2000)

another concern, but validation based on medical records of clinical schizophrenia diagnoses in Stockholm County estimated that 80%-85% of these met the operational diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised. 5uring the study period there were important changes in psychiatric care offered to patients with schizophrenia: outpatient treatment replaced long term inpatient care.In Stockholm between 1976 and 1994, the number of hospital bed days associated with schizophrenia fell by 64%, and this reduction in beds is the most probable explanation for the rising mortality.The same conclusion was drawn in a Danish study reporting increasing mortality from suicide. 3 Our findings emphasise the importance of monitoring trends in mortality for patients with schizophrenia as well as for other patient groups as indicators of outcome and quality of psychiatric and medical care.Contributors: UÖ had the original idea for the study, coordinated and designed it, and wrote the paper.NC contributed to the data analysis and discussion of
National Health Work Force Policy
Authors: Richard Amerling
Journal: Annals of Internal Medicine (1995)

Letters1 October 1995National Health Work Force PolicyRichard Amerling, MDRichard Amerling, MDBeth Israel Medical Center; New York, NY 10003Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-7-199510010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In its position paper on national health work force policy [1], the College revives one of the most obnoxious components of the now-defunct Clinton Health Security Act-government control of physician allocation. There are many reasons why this idea should be abandoned.First, data are again being misused to create a “crisis.” The fact that 68% of physicians who together deliver the best health care in the world consider themselves specialists hardly constitutes a crisis requiring urgent government regulation. Anyone in the trenches knows that most of these specialists are either generalists with a specialty interest or specialists ...References1. American College of Physicians. A national health work force policy. Ann Intern Med. 1994; 121:542-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Richard Amerling, MDAffiliations: Beth Israel Medical Center; New York, NY 10003 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1995Volume 123, Issue 7Page: 555KeywordsFellowshipsHealth careHealth care qualityHealth maintenance organizationsMotivationResidencyTouch ePublished: 15 August 2000 Issue Published: 1 October 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Systolic and Diastolic Abnormalities of the Left Ventricle in Coronary Artery Disease
Authors: J. D. BRISTOW, BRUCE E. VAN ZEE, MELVIN P. JUDKINS
Journal: Circulation (1970)

Left ventricular volume and circumference were calculated from cineangiocardiograms at 60 frames/sec in 15 patients with arteriographically proven coronary artery disease (CAD) and five control subjects. The patients with CAD had no mitral regurgitation and had an average end-diastolic volume equivalent to that reported by others in normal subjects and to that of the control group. The average end-diastolic pressure was higher in CAD and was often abnormal, despite lack of increase in enddiastolic volume. The ejection was lower in the CAD group as was the extent of circumferential fiber shortening. Maximal and mean rates of fiber shortening correlated positively with ejection fraction and were low in some individuals with CAD. We conclude that our patients without significant increase in left ventricular enddiastolic volume had abnormalities of diastolic compliance and contractile performance.
Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with α9β1 and α4β1 integrins
Authors: Jochen Grassinger, David N. Haylock, Melonie J. Storan, Gemma O. Haines, Brenda Williams, Genevieve A. Whitty, Andrew R. Vinson, Cheang Ly Be, Songhui Li, Esben S. Sørensen, Patrick P.L. Tam, David T. Denhardt, Dean Sheppard, Peter F. Choong, Susan K. Nilsson
Journal: Blood (2009)
In the Absence of IL-12, CD4+ T Cell Responses to Intracellular Pathogens Fail to Default to a Th2 Pattern and Are Host Protective in an IL-10−/− Setting
Authors: Dragana Jankovic, Marika C. Kullberg, Sara Hieny, Patricia Caspar, Carmen M. Collazo, Alan Sher
Journal: Immunity (2002)
The Effects of pH on Gastric Mucosal Toxicity of Acetylsalicylic Acid—A Gastrocamera Study.
Authors: William B. Thorsen
Journal: Annals of Internal Medicine (1967)

s1 May 1967The Effects of pH on Gastric Mucosal Toxicity of Acetylsalicylic Acid—A Gastrocamera Study.William B. Thorsen Jr., M.D., Dennis Western, B.A., Yoshihisha Tonaka, M.D., John F. Morrissey, M.D., F.A.C.P.William B. Thorsen Jr., M.D.Search for more papers by this author, Dennis Western, B.A.Search for more papers by this author, Yoshihisha Tonaka, M.D.Search for more papers by this author, John F. Morrissey, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1032_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe effect of pH on the toxicity of acetylsalicylic acid to the gastric mucosa was studied in 20 healthy volunteers. Subjects were studied at weekly intervals, 30 min after ingestion of acetylsalicylic acid tablets (0.6 g) with 100 ml of 1.0 N sodium bicarbonate, pH 8.3, or with 100 ml of 0.1 N hydrochloric acid, pH 1.3. Alkaline and acid solutions ingested with placebo tablets were controls. Ten subjects ingested acetylsalicylic acid (2.4 g) daily for 5 days. A 7-day minimum was allowed between examinations to permit the gastric mucosa to return to normal. Mucosal changes were documented by intragastric... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William B. ThorsenJr., M.D.; Dennis Western, B.A.; Yoshihisha Tonaka, M.D.; John F. Morrissey, M.D., F.A.C.P.Affiliations: Madison, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeptic Ulcer: A Review of the Recent Literature on Various Clinical Aspects 1 May 1967Volume 66, Issue 5Page: 1032-1033KeywordsBicarbonatesGastric mucosaGastroenterology and hepatologyHydrochloric acidIngestionSodiumToxicity ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
Current Trends in the Management of Breast Cancer
Authors: LaSalle D. Leffall
Journal: JAMA (1977)

This book gives an updated account of our current knowledge concerning breast cancer, emphasizing its epidemiology, radiology, pathology, and treatment. The senior author points out that more detailed information may be obtained from larger volumes. The entire book is well done and will answer questions for medical students, house staff, and practicing physicians. The first chapter (on epidemiology) discusses risk factors, which include geographic and ethnic factors, increasing age, age at first giving birth, parity, age at menarche, age at natural menopause, oophorectomy, nutritional considerations, previous cancer, familial history, and prior benign breast disease. The chapter on breast cancer pathology emphasizes the correlation of histological findings with prognosis and treatment and discusses the concepts of in situ carcinoma, which is not a clinically detectable lesion. The chapter on radiology points out the great value of mammography. The authors express their opinions regarding the various forms of therapy and their relative
Clinical Lecture on Peliosis Rheumatica
Authors: M. Anderson
Journal: BMJ (1883)

GIENTLEMEN,-The affection to which the term Peliosis rheumatica has been given by Sch6nlein, and which is also named Purpura rheumatica, is generallytmet with in young persons, or, at all events, age thirty years, and those who have apparently previously good health.The first symptom usually com- plained of is a painful affection of the joints, especially of the ankles knees, accompanied at times with more or less swelling redness, and generally wvith slight fever.Within a few days, numerous livid or blackish spots, the result of extravasation of blood corium, make their appearance upon the skin-most fre- quently upon the extremities, especially the legs and&near the joints affected;these vary in size and shape, but generally they are rounded, of a pin-head (stigmata) to that of a splitpea (petechie), although occasionally they are much larger, may irregular shapes (ecchymoses).When the cutamanifestations are fully developed, the joint-affection and feverishness usually subside; and thenAthe spots pass through the stages as case of black eye, with which most of us are familiar, in our own persons or in that of our friends-so that, two, the symptoms have disappeared.The disease is,however, too often kept up owing to the development of successive crops hiemorrhagic spots, each crop being accompanied by a re- currence the fever and joint-affection.The new crop may appear old one has faded away, or there may be a variable complete immunity between each paroxysm, so that the of the disease may be from weeks to months, or years.we had in Ward v, a couple of years ago, a servant girl fifteen years of age, who had had it more or less for eight years is, however, exceptional.Now, let us compare these symptoms with those present in the girl lies in Bed vs of Ward iv.She is six years of age, admitted on April 24th.About fifteen months ago, girl's mother noticed a rash, which came out at night andi disappeared the morning, on the calves of the legs at first, but gradually extending to the thighs and arms as well, and which she that of measles or scarlet fever.Three months after this, that, when it faded in the morning, it left bluish-black blotches behind, which disappeared more slowly.For the last six months, swelling and pain in her ankles, knees, wrists, and fingers have preceded each fresh crop of eruption.
Psychiatric Illness in General Practice: A Detailed Study Using a New Method of Case Identification
Authors: D. P. Goldberg, B. Blackwell
Journal: BMJ (1970)

A self-administered questionary (the General Health Questionnaire) aimed at detecting current psychiatric disturbance was given to 553 consecutive attenders to a general practitioner9s surgery. A sample of 200 of these patients was given an independent assessment of their mental state by a psychiatrist using a standardized psychiatric interview. Over 90% of the patients were correctly classified as “well” or “ill” by the questionary, and the correlation between questionary score and the clinical assessment of severity of disturbance was found to be +0·80. The “conspicuous psychiatric morbidity” of a suburban general practice assessed by a general practitioner who was himself a psychiatrist and validated against independent psychiatric assessment was found to be 20%. “Hidden psychiatric morbidity” was found to account for one-third of all disturbed patients. These patients were similar to patients with “conspicuous illnesses” in terms both of degree of disturbance and the course of their illnesses at six-month follow-up, but were distinguished by their attitude to their illness and by usually presenting a physical symptom to the general practitioner. When 87 patients who had been assessed as psychiatric cases at the index consultation were called back for follow-up six months later, two-thirds of them were functioning in the normal range. Frequency of attendance at the surgery in the six months following index consultation was found to have only a modest relationship to severity of psychiatric disturbance. It is argued that minor affective illnesses and physical complaints often accompany each other and usually have a good prognosis.
Synovial biopsy in arthritis.
Authors: M Edgar
Journal: BMJ (1979)

patients, associated with any evidence of drug-induced lupus.It is possible therefore that extension of Dr Marshall's investigation to larger numbers of patients, with appropriate age-matched controls, could result in conclusions different from those reported.However, their finding that all prazosin-related ANF patterns were of the speckled variety is very unusual.When ANF did occur in patients on prazosin in our study it was not restricted to this mor- phological pattern.This suggests that there may be some unusual factors influencing results in Dr Marshall's patients.
CARDIAC ARREST DUE TO VENTRICULAR HERNIATION
Authors: Otto B. G. Munchow
Journal: JAMA (1960)

During the past few years, cardiac resuscitation has become a well-established procedure. Because the time factor is the most important single element, the percentage of successful revivals has been much higher inside the operating theater than outside. Both cardiac catastrophies to be presented below occurred outside the operating room. Favorable circumstances which permitted immediate treatment made resuscitation of the patient possible each time. Unless effective cardiac action is immediately restored, there are three reasons why it is usually advisable to open the pericardium: (1) proper inspection of the cardiac muscle may be difficult or impossible through the pericardial layer; (2) rhythmical compression of the heart sufficiently strong to maintain a desirable arterial pressure and circulation can rarely be performed with the pericardium intact; (3) any traumatic insult to the heart may produce considerable serous or hemorrhagic intrapericardial effusion, which necessitates an opening for drainage to prevent a tamponade. A dangerous
IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study
Authors: B. K. Ballmer-Weber, J. Lidholm, M. Fernández-Rivas, S. Seneviratne, K.-M. Hanschmann, L. Vogel, P. Bures, P. Fritsche, C. Summers, A. C. Knulst, T.-M. Le, I. Reig, N. G. Papadopoulos, A. Sinaniotis, S. Belohlavkova, T. Popov, T. Kralimarkova, F. de Blay, A. Purohit, M. Clausen, M. Jedrzejczak-Czechowcz, M. L. Kowalski, R. Asero, R. Dubakiene, L. Barreales, E. N. Clare Mills, R. van Ree, S. Vieths
Journal: Allergy (2015)

Background We tested the hypothesis that specific molecular sensitization patterns correlate with the clinical data/manifestation in a European peanut-allergic population characterized under a common protocol. Methods Sixty-eight peanut-allergic subjects and 82 tolerant controls from 11 European countries were included. Allergy to peanut and lowest symptom-eliciting dose was established by double-blind placebo-controlled food challenge in all but anaphylactic subjects. Information of early or late (before or after 14 years of age) onset of peanut allergy was obtained from standardized questionnaires. IgE to peanut allergens rAra h 1–3, 6, 8–9, profilin and CCD was determined using ImmunoCAP. Results Seventy-eight percent of peanut allergics were sensitized to peanut extract and 90% to at least one peanut component. rAra h 2 was the sole major allergen for the peanut-allergic population. Geographical differences were observed for rAra h 8 and rAra h 9, which were major allergens for central/western and southern Europeans, respectively. Sensitization to rAra h 1 and 2 was exclusively observed in early-onset peanut allergy. Peanut-tolerant subjects were frequently sensitized to rAra h 8 or 9 but not to storage proteins. Sensitization to Ara h 2 ≥ 1.0 kUA/l conferred a 97% probability for a systemic reaction (P = 0.0002). Logistic regression revealed a significant influence of peanut extract sensitization and region on the occurrence of systemic reactions (P = 0.0185 and P = 0.0436, respectively). Conclusion Sensitization to Ara h 1, 2 and 3 is usually acquired in childhood. IgE to Ara h 2 ≥ 1.0 kUA/l is significantly associated with the development of systemic reactions to peanut.
Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma
Authors: Jay Gunawardana, Fong Chun Chan, Adèle Telenius, Bruce Woolcock, Robert Kridel, King L Tan, Susana Ben-Neriah, Anja Mottok, Raymond S Lim, Merrill Boyle, Sanja Rogic, Lisa M Rimsza, Chrystelle Guiter, Karen Leroy, Philippe Gaulard, Corinne Haioun, Marco A Marra, Kerry J Savage, Joseph M Connors, Sohrab P Shah, Randy D Gascoyne, Christian Steidl
Journal: Nature Genetics (2014)
The effect of institutional experience on the outcome of primary angioplasty for acute MI
Authors: Ronald P. Caputo, John J. Lopez, Robert C. Stoler, Craig B.H. Sukin, Kalon K.L. Ho, David J. Cohen, Richard E. Kuntz, Aaron Berman, Donald S. Baim, Joseph P. Carrozza
Journal: Journal of the American College of Cardiology (1996)