tbuckley/cabot-search huggingface dataset:
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the αIIbβ3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia
Authors: Cedric Ghevaert, Alexandre Salsmann, Nicholas A. Watkins, Elisabeth Schaffner-Reckinger, Angela Rankin, Stephen F. Garner, Jonathan Stephens, Graham A. Smith, Najet Debili, William Vainchenker, Philip G. de Groot, James A. Huntington, Mike Laffan, Nelly Kieffer, Willem H. Ouwehand
Journal: Blood (2007)
Abstract 1596: Effect of combined treatment with ursolic acid (UA) and resveratrol (Res) on skin tumor promotion by TPA
Authors: Jiyoon Cho, Okkyung Rho, Steve Carbajal, Jacob Junco, Thomas J. Slaga, John DiGiovanni
Journal: Cancer Research (2012)

Abstract In recent years, emerging evidence suggests that cancer chemopreventive agents when combined might be more effective than when given alone. Both UA and Res have been shown to reduce inflammation and tumor development in various tissues. In mouse skin, both compounds have been shown to block skin tumor promotion by TPA and reduce TPA-induced inflammation. In this study, we have further evaluated the effect of UA and Res on skin tumor promotion with emphasis on examining combinations of these agents. For these experiments, UA, Res and combinations of UA + Res were applied topically (various doses) prior to TPA treatment on mouse skin. The combination of UA + Res showed additive and possibly synergistic inhibition of TPA-induced epidermal hyperproliferation as assessed by both epidermal hyperplasia and BrdU labeling index. The effect of UA, Res and the combination of UA + Res on epidermal signaling pathways was also evaluated. The combination of UA + Res significantly inhibited activation of epidermal Akt, NF-κB, p38 MAPK, and JNK in response to TPA treatment compared to the treatment with the individual compounds. The combination of UA + Res also dramatically reduced the induction of epidermal Cox-2 by TPA. Notably, combined treatment with UA and Res induced a dramatic increased phosphorylation of AMPK-α suggesting that AMPK activation may also play a critical role in the ability of the combination to alter skin tumor promotion. Combination treatment during skin tumor promotion showed greater inhibition of tumor multiplicity than with either agent alone. In further experiments, the effect of UA, Res and UA + Res on proliferation of bulge-region keratinocyte stem cells (KSCs) was evaluated. Both UA and Res treatment inhibited TPA-induced proliferation and migration of bulge-region KSCs. Furthermore, the combination of UA + Res appeared to be more effective at blocking proliferation of these cells from the hair follicle when compared with the single compound-treated groups. Taken together, these data suggest that the combination of UA + Res has either additive or synergistic inhibitory effects on keratinocyte proliferation (including KSCs) and various signaling pathways. These effects may explain the greater inhibition of skin tumor promotion by the combination of UA and Res. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1596. doi:1538-7445.AM2012-1596
Cimetidine and thrombocytopenia.
Authors: A J Isaacs
Journal: BMJ (1980)

The control subjects had recently attended the fracture clinic and were otherwise healthy.They were matched with the patients for age (± 5 years), sex, social class, and marital status and were not significantly different from the patients in height or weight distribution.The controls were interviewed about their diet in the same manner as the patients.The statistical significance of differences was calculated by Student's t test or by Wilcoxon's rank sum test for paired data.The table shows the dietary intake of the patients and controls.There was no significant difference in any food component between the two groups.In particular, there was no difference in the intake of dietary fibre or refined sugar.
Abstract 5233: Imaging breast cancer xenograft using multienergy modality and target-specific molecular agents
Authors: Wei Wang, Xiuchun Qiu, Arlin G. Carmeron, Siyuan Zhang, Dihua Yu, Michel E. Mawad, Ke Shi
Journal: Cancer Research (2010)

Abstract Interleukin-11 (IL-11) and its receptor (IL-11R) involve in many normal and abnormal biological progress. Studies strongly suggest that interleukin-11 (IL-11) plays an important role in early bone metastases. We synthesized an IL-11Rα homing peptide identified from in vivo patient screening with a peptide phage display and to conjugate it to both an NIR dye for optical imaging and a chelator for nuclear imaging. Cell binding and internalization of the imaging agent was evaluated using NIR confocal microscopy and human breast cancer MDA-MB-231 cell lines. Specificity was demonstrated by comparing with free dye and blocking with the unlabeled recombinant IL-11. Tumor cell growth, vasculature formation and IL-11 agent binding to the tumor were demonstrated in vivo using luciferase positive tumor xenograft model and the injection of both vasculature and IL-11 agents. Tissue autoradiography and H&amp;E staining of the same tissue sections were conducted to verify imaging data. Biodistribution was analyzed by percentage injection dose per gram tissue. Confocal microscopy demonstrated that the target specific imaging agent accumulated on the cell membrane and internalized into cell while free dye had significant lower cell binding than the IL-11 agent. Pre-incubated by the presence of IL-11 protein significantly decreased the agent binding to the cell. Multienergy in vivo imaging revealed the tumor growth, vasculature formation and IL-11 agent binding on the tumor as early as 4 days after the tumor cell inoculation. Overlaid the autoradiography tissue image with H&amp;E staining results demonstrated the heterogeneous distribution of the imaging agent inside tumor mass. Furthermore, the images showed the IL-11 agent only bound to the viable tumor cells. These results suggest a potential imaging agent for study IL-11Rα expression at noninvasive whole body level as well as organ, tissue and cellular levels. *WW, XQ: These authors contributed equally to this work. Grant support: DoD W81XWH-08-1-0489, Department of Defense, Department of Radiology research fund, Curtis Hankamer Basic Research Fund and the L.E. and Josephine S. Gordy Memorial Cancer Research Fund, Dan L. Duncan Cancer Center Scholar, American Society for Clinical Oncology and Hope Street Kids Foundation, and National Science Foundation of China grants (30471988, 30973409, and 30873027). Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5233.
Five futures for academic medicine
Authors: Roger K A Allen
Journal: BMJ (2005)

EDITOR—Godlee writes that academic medicine lacks vision and leadership in relation to the report from the International campaign to Revitalise Academic Medicine.1 2 Universities are no longer intellectual arenas or places of scientific debate. Drug company money salts most departments. Machines can analyse whatever DNA probe until a “significant” correlation is squeezed like grapes in a wine press.The next scientific meeting is only …
Metastatic Renal Cell Carcinoma and Carcinoembryonic Antigen Levels
Authors: GABRIEL HORTOBAGYI
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 April 1985Metastatic Renal Cell Carcinoma and Carcinoembryonic Antigen LevelsGABRIEL HORTOBAGYI, M.D., HERBERT FRITSCHE, Ph. D., JORGE QUESADA, M.D.GABRIEL HORTOBAGYI, M.D.Search for more papers by this author, HERBERT FRITSCHE, Ph. D.Search for more papers by this author, JORGE QUESADA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-555 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Carcinoembryonic antigen is a tumor marker associated with various malignant tumors (digestive tract, lung, breast, and bladder) and may be elevated in the circulation of patients with benign conditions (1). Although carcinoembryonic antigen levels may not be quantitatively related to host tumor cell burden, they are more frequently elevated in patients with advanced or disseminated disease than in patients with early or only primary malignancies (2). Sequential carcinoembryonic antigen measurements have been used successfully for monitoring of metastatic breast and gastrointestinal cancer and in the detection of recurrent tumors of similar etiology (3, 4).Twenty-five patients with...References1. REYNOSO G, CHU T, and HOLYOKE E. Carcinoembryonic antigen in patients with different cancers. JAMA. 1972;220:361-5. CrossrefMedlineGoogle Scholar2. TORMEY D, WAAKLES T, and SNYDER J. Biological markers in breast carcinoma: III. Clinical correlations with carcinoembryonic antigen. Cancer. 1974;39:2397-404. CrossrefGoogle Scholar3. LOKICH J, ZAMCHECK N, and LOWENSTEIN M. Sequential carcinoembryonic antigen levels in the therapy of metastatic breast cancer. Ann Intern Med. 1978;89:902-6. LinkGoogle Scholar4. SUGARBAKER P, ZAMCHECK N, and MOORE F. Assessment of serial carcinoembryonic antigen (CEA) assays in postoperative detection of recurrent colon cancer. Cancer. 1976;38:2310-5. CrossrefMedlineGoogle Scholar5. HORTOBAGYI G, FRYE D, and PAPADOPOULOS N. Phase I clinical of copovithane, a new antitumor agent [Abstract]. Proc Am Assoc Clin Res. 1983;24:145. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GABRIEL HORTOBAGYI, M.D.; HERBERT FRITSCHE, Ph. D.; JORGE QUESADA, M.D.Affiliations: M. D. Anderson Hospital and Tumor Institute at Houston Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1985Volume 102, Issue 4Page: 555-556KeywordsBladderCarcinoembryonic antigenEtiologyGastrointestinal cancersGastrointestinal tractLung and intrathoracic tumorsMalignant tumorsMetastasisRenal cell carcinoma ePublished: 1 December 2008 Issue Published: 1 April 1985 PDF downloadLoading ...
Watchdog rules that Merck violated the UK industry code of practice
Authors: Owen Dyer
Journal: BMJ (2006)

Saw palmetto extract is not effective for BPH 20, 100Saw palmetto, a herbal extract taken by more than two million US men for relief from the symptoms of benign prostatic hyperplasia (BPH), showed no benefit over placebo, a study has found.The year long, double blind, randomised trial was reported this week in the New England Journal of Medicine (2006;354:557-66).The herbal extract, taken from the berries of a small, palm-like north American plant, is commonly recommended as an alternative to prescription drugs.An accompanying editorial says additional rigorous, placebo controlled studies are needed before conclusions can be made about the long term effectiveness and safety of other saw palmetto preparations and that herbal remedies should be subjected to clinical trials of the same quality needed for approval of standard drugs.Until this is done, it says, doctors are responsible for protecting patients from the risks of unproved therapies.
Cancer in old age---is it inadequately investigated and treated?
Authors: N J Turner, R A Haward, G P Mulley, P J Selby
Journal: BMJ (1999)

The proportion of the United Kingdom population over 75 years of age will increase from around 7% to nearly 11% in the next 50 years, with a disproportionate rise in those over 85 years. There will be a large increase in the number of elderly patients with cancer Already over one third of cancers are diagnosed in people over 75, yet we do not know how best to investigate and treat cancers in these patients. Many clinical trials have used arbitrary upper age limits. Even trials in allegedly elderly subjects start at age 65. Very few studies include large numbers of old (over 75) or very old (over 85) people.1 The role and effectiveness of many cancer treatments is therefore not evidence based in those most affected.

Studies of cancer care in elderly patients show fewer diagnostic and staging procedures and less treatment with advancing age. Disease specific survival rates decline with age.2–6 This is illustrated by data from the Yorkshire Cancer Registry on histological confirmation (a useful marker for the adequacy of investigation), receipt of definitive treatment, and relative survival in relation to age group (table).7 The Yorkshire Cancer Registry is one of the registries used in the Eurocare study. It covers a population of 3.7 million, constituting 7.2% of the total population of England and Wales.

View this table:

Proportion (%) of cancers confirmed by histology, cancer patients with no definitive treatment, and cancer patients surviving five years, by age group, Yorkshire 1989-93



#### Summary points

Although more than a third of cancers are diagnosed in people over 75, this group is less extensively investigated and receives less treatment than younger patients

75 year old women and 75 year old men have life expectancies of 11.1 years and 8.5 years respectively

Reduced levels of intervention are not wholly explained …
SEROLOGICAL STUDIES IN RHEUMATIC FEVER
Authors: Edward E. Fischel, Ruth H. Pauli
Journal: The Journal of Experimental Medicine (1949)

1. An attempt was made to repeat and extend various tests which have been presumed to demonstrate specific antigens and antibodies in rheumatic fever. 2. The "phase reaction" appears to be an inconstant phenomenon probably related to a colloidal abnormality of the serum, rather than to a specific antigen-antibody system. 3. No specific autoantibodies to human tissue extracts were demonstrable by complement fixation or by the collodion particle technique. Variable results were noted with the same test sera on different occasions, and positive reactions with control tissues and control sera were observed. 4. The possibility should be considered that autoantibodies are not necessarily specific for rheumatic fever but may be manifestations of the occurrence of a type of reaction similar to a biologically false positive Wassermann reaction.
Instructions for Patients
Authors: John J. Massarelli
Journal: JAMA (1982)

This is a nonbook in the sense that it was not written to be read from beginning to end, or used as a reference, or to supply enjoyment or education to its owner. It consists of handouts for patients on 249 subjects, including 21 diets, and an additional 17 anatomic line drawings that can be marked to illustrate the patient's lesions. It is paperbound. Each page is perforated for tearing out, and three holes are present for saving them in a loose-leaf binder. On the back of the title page is a brief statement inviting physicians "to reproduce these instruction sheets on their office copying machines for distribution to patients." The sheets are more than "Instructions for Patients." Each begins with a section headed "General Information," and most of these provide excellent explanations of the problems under consideration. The subjects encompass a wide range, suitable for primary physicians whose practices
Phase I/II trial of intermittent subcutaneous IL-2 administration in pediatric patients with moderate immune suppression: Results of Pediatric AIDS Clinical Trials Study 402
Authors: Savita Pahwa, Petronella Muresan, John Sleasman, Terry Fenton, John Moye, Audra Deveikis, Diane Wara, Russ Van Dyke
Journal: Journal of Allergy and Clinical Immunology (2007)
SEMI-QUANTITATIVE VISUAL ANALYSIS OF MYOCARDIAL PERFUSION SCINTIGRAPHY IS HELPFUL FOR DIFFERENTIAL DIAGNOSIS OF BUNDLE BRANCH BLOCK AND MYOCARDIAL INFARCTION
Authors: Kyu Young Choi, Eun Joo Cho, Beom June Kwon, Dong Bin Kim, Seong Won Jang, Jae Hyung Kim
Journal: Journal of the American College of Cardiology (2012)
RELATIONSHIP OF QRS MORPHOLOGY ON REVERSE REMODELING AND CLINICAL OUTCOMES WITH CARDIAC RESYNCHRONIZATION THERAPY (CRT) IN MILD HEART FAILURE: RESULTS FROM THE RESYNCHRONIZATION REVERSES REMODELING IN SYSTOLIC LEFT VENTRICULAR DYSFUNCTION (REVERSE) TRIAL
Authors: Michael Robert Gold, Cecilia Linde, Angel Arenal Maiz, Jean-Claude Daubert, William T. Abraham
Journal: Journal of the American College of Cardiology (2010)
A CASE OF WIDESPREAD MOTOR PARALYSIS DUE TO MULTIPLE SYMMETRICAL PERIPHERAL NEURITIS, FOLLOWING AN UNUSUALLY MILD ATTACK OF SCARLET FEVER
Authors: F. W. Price
Journal: BMJ (1906)

MOTOR PARALYSIS DUE TO PERIPHERAL NEURITIS.LAPRIL 21, i196.been elucidated.The results described above do, however, show the prophylactic importance of slow decom- pression, and suggest that with careful attention to various details the upper limits of pressure, both for caissons and diving operations, can be much extended.
Spread of Excitation During Premature Ventricular Systoles
Authors: A. M. SCHER, A. C. YOUNG, A. L. Malmgren, R. V. Erickson, R. A. Becker
Journal: Circulation Research (1955)

Premature systoles were elicited at many points in the dog heart and the resultant pattern of excitation plotted in detail with a multipolar electrode and a 16-channel oscilloscope. In premature systoles, most of the mural endocardium is excited by a wave travelling at about 1 meter per second. These results indicate that in a normally originating beat the mural endocardium is excited by branched Purkinje tissue, the elements of which conduct at about 1 meter per second. The transmural velocity of the wave of depolarization in premature systoles is about 0.3 meter per second. No evidence was found for intramural penetration of Purkinje fibers. Intramural potentials recorded on stimulation give some insight into normal intramural potentials.
Effect of genetic profiling on prediction of therapeutic resistance and survival in adult acute myeloid leukemia
Authors: R B Walter, M Othus, E M Paietta, J Racevskis, H F Fernandez, J-W Lee, Z Sun, M S Tallman, J Patel, M Gönen, O Abdel-Wahab, R L Levine, E H Estey
Journal: Leukemia (2015)
Angiosarcoma of the eyelid: Yellow plaques causing ptosis
Authors: Candace S. Lapidus, Francis C. Sutula, Miguel J. Stadecker, John E. Vine, Donald J. Grande
Journal: Journal of the American Academy of Dermatology (1996)

Angiosarcomas are aggressive malignant tumors of vascular origin that may originate anywhere in the body. They occur most commonly on the head and neck region of elderly men. 1-3  The tumors usually present as bruiselike macules, plaques, or nodules and occasionally as chronic edema or cellulitis. 1,4  Diagnosis is often delayed by the benign appearance of the tumor and its variable presentation : it is commonly mistaken for a bruise, hemangioma, or focal bacterial or fungal infection. Prognosis for patients with angiosarcoma of the face and scalp is poor, with a 5-year survival rate of approximately 12% to 27%. 2,3,5,6
SgIGSF is a novel biliary–epithelial cell adhesion molecule mediating duct/ductule development
Authors: Akihiko Ito, Yuji Nishikawa, Kazuhiro Ohnuma, Ikuyo Ohnuma, Yu-ichiro Koma, Ayuko Sato, Katsuhiko Enomoto, Tohru Tsujimura, Hiroshi Yokozaki
Journal: Hepatology (2007)

Spermatogenic immunoglobulin superfamily (SgIGSF) is an intercellular adhesion molecule of the nectin-like family. While screening its tissue distribution, we found that it was expressed in fetal liver but not adult liver. In the present study, we examined which cells in developing and regenerating liver express SgIGSF via immunohistochemistry and Western blot analysis. In developing mouse liver, SgIGSF expression was transiently upregulated at perinatal ages and was restricted to the lateral membrane of biliary epithelial cells (BECs). In regenerating rat livers from the 2-acetylaminofluorene/partial hepatectomy model, SgIGSF was detected exclusively in oval cells that aligned in ductal and trabecular patterns by the second week posthepatectomy. In human livers, fetal and newborn bile ducts and cirrhotic bile ductules were clearly positive for SgIGSF, whereas disease-free adult bile ducts were negative. To investigate the role of SgIGSF in bile duct/ductule formation, we used an in vitro model in which rat hepatocyte aggregates embedded in collagen gels containing insulin and epidermal growth factor extend epithelial sheets and processes in the first week and form ductules within a month. The process and ductular cells were continuously positive for SgIGSF and cytokeratin 19, a BEC marker. When the aggregate culture was started in the presence of a function-blocking anti-SgIGSF antibody, the number of epithelial processes per aggregate was reduced by 80%.We propose that SgIGSF is a novel and functional BEC adhesion molecule that is expressed for a limited time during active bile duct/ductule formation.
General practitioners' pay.
Authors: E Housden, J Ford
Journal: BMJ (1991)

of their time to counselling patients and their families and, inevitably, supervising their continuing and terminal care.Many patients have no other hospital based specialists to turn to.Attempts to reduce junior staffing levels to ensure that well trained juniors will eventually find consultant posts and moves to limit their working hours have also exacerbated problems within the specialty.Faced with similar problems, the Royal Australian College of Radiologists started putting numbers to its complaints, estimating how many patients were being deprived of essen- tial treatment and how much the delays in treatment were costing.3Perhaps the royal college here should follow this lead.Unless more clinical oncologists are appointed substandard care for Britain's patients with cancer looks likely to continue well into the next century.
Out of Ireland
Authors: Jack Coulehan
Journal: JAMA (2014)

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