Suppression of Immunologic Responsiveness in Uremia
Authors: W. E. C. WILSON
Journal: Annals of Internal Medicine (1965)

Article1 January 1965Suppression of Immunologic Responsiveness in UremiaW. E. C. WILSON, M.D., CHARLES H. KIRKPATRICK, M.D., DAVID W. TALMAGE, M.D.W. E. C. WILSON, M.D., CHARLES H. KIRKPATRICK, M.D., DAVID W. TALMAGE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent developments in surgery have resulted in technically successful transplantation of human kidneys prior to the solution of many fundamental problems in transplantation immunology. The consequence has been a spectrum of clinical observations that varies from generally successful renal transplantation between identical twins to less frequent success when a genetically dissimilar donor is employed. Nevertheless, when comparison is made with the fate of other transplanted organs that elicit an immune response, a remarkable degree of success has been achieved with human kidney allografts. These favorable results suggested that the chronically uremic patient may have a unique alteration of his immunologic...References1. KIRKPATRICKWILSONTALMAGE CHWEDW: Immunologic studies in human organ transplantation. I. Observation and characterization of suppressed cutaneous reactivity in uremia. J. Exp. Med. 119: 727, 1964. CrossrefMedlineGoogle Scholar2. ROWLANDSWILSONKIRKPATRICK DTWECH: Immunologic studies in human organ transplantation. II. The histology of passively transferred delayed hypersensitivity. J. Allerg. 35: 242, 1964. CrossrefMedlineGoogle Scholar3. WILSONKIRKPATRICKTALMAGE WECHDW: Immunologic studies in human organ transplantation. III. The relationship of delayed cutaneous hypersensitivity to the onset of attempted kidney allograft rejection. J. Clin. Invest. 43: 1881, 1964. 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Public Health Service.Requests for reprints should be addressed to Charles H. Kirkpatrick, M.D., Department of Medicine, University of Kansas Medical Center, Kansas City, Kan. 66103. 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HENDERSON, M.B.The Role of Organ Transplantation in PediatricsAN ASSESSMENT OF THE MIXED LEUCOCYTE REACTION IN RENAL FAILURE 1 January 1965Volume 62, Issue 1Page: 1-14KeywordsAntigensKidneysMedical servicesMonozygotic twinsRenal transplantationSalmonellaSurgeryTransplantationTransplantation immunologyTyphoid ePublished: 1 December 2008 Issue Published: 1 January 1965 Copyright & PermissionsCopyright ©, 1965, by The American College of PhysiciansPDF downloadLoading ...