Gastric Secretion in Ulcerogenic Tumors of the Pancreas
Authors: RICHARD D. RUPPERT
Journal: Annals of Internal Medicine (1967)

Article1 October 1967Gastric Secretion in Ulcerogenic Tumors of the PancreasRICHARD D. RUPPERT, M.D., NORTON J. GREENBERGER, M.D., FLOYD M. BEMAN, M.D., FRANK M. MCCULLOUGH, M.D.RICHARD D. RUPPERT, M.D.Search for more papers by this author, NORTON J. GREENBERGER, M.D.Search for more papers by this author, FLOYD M. BEMAN, M.D.Search for more papers by this author, FRANK M. MCCULLOUGH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-4-808 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEleven years have elapsed since Zollinger and Ellison (1) reported the association of peptic ulcer disease and tumors of the pancreas. To date, over 400 cases have been reported. However, it is not generally appreciated that four of the commonly used tests of gastric acid secretion may not suggest the correct diagnosis. Normal values have been reported for basal acid secretion, histamine-stimulated acid secretion, the ratio of basal/stimulated acid secretion, and 12-hr overnight acid secretion in patients with ulcerogenic tumor of the pancreas (2, 3). We have studied gastric secretion in five patients with Zollinger-Ellison syndrome and in 300 other...References1. ZOLLINGERELLISON RMEH: Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann. Surg. 142: 709, 1955. CrossrefMedlineGoogle Scholar2. AOYAGISUMMERSKILL TWH: Gastric secretion with ulcerogenic islet cell tumor. Importance of basal acid output. Arch. Intern. Med. (Chicago) 117: 667, 1966. CrossrefMedlineGoogle Scholar3. ELLISONWILSON EHSD: The Zollinger-Ellison syndrome: re-appraisal and evaluation of 260 registered cases. Ann. Surg. 160: 512, 1964. CrossrefMedlineGoogle Scholar4. KAY AW: Effect of large doses of histamine on gastric secretion of HCl. An augmented histamine test. Brit. Med. J. 2: 77, 1953. CrossrefMedlineGoogle Scholar5. LAI SK: Studies on gastrin. Gut 5: 327, 1964. CrossrefMedlineGoogle Scholar6. MARKSSELZERLOUWBANK INGJHS: Zollinger-Ellison syndrome in a Bantu woman, with isolation of a gastrin-like substance from the primary and secondary tumors. I. Case report. Gastroenterology 41: 77, 1961. CrossrefMedlineGoogle Scholar7. OBERHELMANNELSENJOHNSONDRAGSTEDT HATSANLR: Ulcerogenic tumors of the duodenum. Ann. Surg. 153, 214, 1961. Google Scholar8. BLOCKSMITHHAUBRICHHORN MARFWSRC: Surgical problems in management of islet-cell tumors with gastric hypersecretion. Arch. Surg. (Chicago) 85: 270, 1962. CrossrefMedlineGoogle Scholar9. HUNT JN: Gastric emptying and secretion in man. Physiol. Rev. 39: 491, 1959. CrossrefMedlineGoogle Scholar10. RAWSONENGLANDGILLAMFRENCHSTAMMERS ABMTGGJMFA: Zollinger-Ellison syndrome with diarrhoea and malabsorption. Observations on a patient before and after pancreatic islet-cell tumour removal with-out resort to gastric surgery. Lancet 2: 131, 1960. CrossrefMedlineGoogle Scholar11. CLARKEGLENILLINGWORTH AMAIC: Zollinger-Ellison syndrome treated without gastric surgery. Lancet 1: 1360, 1964. CrossrefMedlineGoogle Scholar12. SHAYCHEYKOIDEBURNETT HWYSMWE: Mechanism of the disordered physiology involved in the Zollinger-Ellison syndrome. Report of a case. Amer. J. Dig. Dis. 7: 401, 1962. CrossrefMedlineGoogle Scholar13. SUMMERSKILL WH: Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet cell hyperplasia. Lancet 1: 120, 1959. CrossrefMedlineGoogle Scholar14. LAWLIDDLESCOTTTAUBER DHGWHWSD: Ectopic production of multiple hormones (ACTH, MSH and gastrin) by a single malignant tumor. New Eng. J. Med. 273: 292, 1965. CrossrefMedlineGoogle Scholar15. WADDELLLEONSINSZUIDEMA WRAJGD: Gastric secretory and other laboratory studies on two patients with Zollinger-Ellison syndrome. New Eng. J. Med. 260: 56, 1959. CrossrefMedlineGoogle Scholar16. SINGLETONKERNWADDELL JWFWR: Diarrhea and pancreatic islet cell tumor: report of a case with a severe jejunal mucosal lesion. Gastroenterology 49: 197, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD D. RUPPERT, M.D.; NORTON J. GREENBERGER, M.D.; FLOYD M. BEMAN, M.D.; FRANK M. MCCULLOUGH, M.D.Affiliations: Columbus, OhioFrom the Division of Gastroenterology, Department of Medicine, Ohio State University College of Medicine, Columbus, Ohio.This study was supported in part by grant FR-34, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Richard D. Ruppert, M.D., Department of Medicine, Ohio State University Hospital, 410 W. 10th Ave., Columbus, Ohio 43210. 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KRAFT, M.D.Zollinger-Ellison SyndromeDiagnosis of Gastrointestinal Cancer: Current Status and Recent ProgressZollinger-Ellison syndromeA study of six patients with hypertrophy of the gastric mucosa with particular reference to albumin metabolismDiagnosis of occult Zollinger-Ellison tumors by gastrin radioimmunoassayThe Assessment of Gastric Acidity and Appraisal of its Clinical ValueGastric AnalysisHyperchlorhydria and Hyperhistaminemia in a Patient with Systemic MastocytosisGastric Secretion in Duodenal Ulcer, with Particular Reference to the Diagnosis of Zollinger-Ellison SyndromeZollinger-Ellison syndromeTHE ASSESSMENT OF GASTRIC SECRETION IN MANHypertrophic, Hypersecretory Protein-losing GastropathyDas Zollinger-Ellison-SyndromNon-Insulin-Secreting Islet Cell TumorsThe PancreasThe Zollinger Ellison Syndrome with Steatorrhea 1 October 1967Volume 67, Issue 4Page: 808-815KeywordsBioassays and physiological analysisGastric ulcersGastrinPancreasPeptic ulcersUlcersZollinger Ellison syndrome ePublished: 1 December 2008 Issue Published: 1 October 1967 PDF downloadLoading ...