Pernicious Anemia without Achlorhydria*†
Authors: EARLE A. HARVEY
Journal: Annals of Internal Medicine (1933)

Article1 May 1933Pernicious Anemia without AchlorhydriaCase ReportEARLE A. HARVEY, M.D., WILLIAM P. MURPHY, M.D.EARLE A. HARVEY, M.D.Search for more papers by this author, WILLIAM P. MURPHY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-11-1393 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChanges in the stomach or in its secretions have been noted as a common finding in pernicious anemia for many years. As early as 1860 Austin Flint1spoke of an absence of gastric secretion and mentioned degenerative changes in the gastric mucosa. In 1877 Fenwick2noted atrophy of the gastric mucous membrane. Achlorhydria was spoken of by Cahn and von Mering3as early as 1886 and again by von Noorden4in 1891. Since these early reports, the absence of free hydrochloric acid from the gastric juice and a low total or combined acidity has usually been considered to be a...Bibliography1 FLINT A: A practical treatise on the diagnosis, pathology and treatment of diseases of the heart, N. Y. Med. Jr., 1860, viii, 267. Google Scholar2 FENWICK S: Lecture on atrophy of the stomach, Lancet, 1877, ii, 1-4, 39-41, 77-78. CrossrefGoogle Scholar3 CAHNVON MERING AJ: Die Säuren des gesunden und kranken Magens, Deutsch. Arch. f. klin. Med., 1886, xxxix, 233-253. Google Scholar4 VON NOORDEN C: Untersuchungen über schwere Anämien (Blut, Stoffwechsel Nervensystem), Charité-Ann., 1891, xvi, 217-266. Google Scholar5 IVYMORGANFARRELL ACJEJI: The effects of total gastrectomy; experimental achylia gastrica in dogs with the occurrence of a spontaneous anemia and anemia in pregnancy, Surg., Gynec. and Obst., 1931, liii, 611-620. Google Scholar6 STRANDELL B: Pernicious anemia; a study of 117 cases, Acta med. 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Jr. Med. Sci., 1930, clxxx, 305-335. CrossrefGoogle Scholar25 MURPHY WP: The parenteral use of liver extract in pernicious anemia, Jr. Am. Med. Assoc., 1932, xcviii, 1051. CrossrefGoogle Scholar26 : Pernicious anemia, Lancet, 1928, i, 115. Google Scholar27 HARRIS S: The liver diet and liver extracts in the treatment of pernicious anemia, Internat. Clinics, 1928, xi, 132. Google Scholar28 JONESJOYCE NWTM: Further remarks on infection of gall-bladder in relation to chronic (pernicious?) anemia, Am. Jr. Med. Sci., 1927, clxxiii, 526. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication September 29, 1932.†From the Medical Clinic of the Peter Bent Brigham Hospital, Boston. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMassive jejunal diverticulosis and subacute combined degeneration of the cordHistamine-containing epithelial cells in rat stomach: A possible storage site for the intrinsic factorMalabsorption and jejunal diverticulosisMalabsorption Syndrome Associated with Intestinal DiverticulosisDie Erkrankungen des erythrocytären SystemsPERNICIOUS ANEMIA UNASSOCIATED WITH ACHLORHYDRIA: CASE REPORT*J. OWEN FINNEY, M.D.THE RELATION OF GASTRIC SECRETION TO HEMATOPOIESIS*THEODORE G. KLUMPP, SIMON KOLETSKY 1 May 1933Volume 6, Issue 11Page: 1393-1406KeywordsAchlorhydriaAtrophyGastric mucosaHospitalsHydrochloric acidMucous membranesPernicious anemiaStomach Issue Published: 1 May 1933 PDF DownloadLoading ...