tbuckley/cabot-search huggingface dataset:
Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy
Authors: Young-Kyo Seo, Tae-Il Jeon, Hansook Kim Chong, Jacob Biesinger, Xiaohui Xie, Timothy F. Osborne
Journal: Cell Metabolism (2011)

Sterol regulatory element-binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we used genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with different dietary conditions that enrich for specific SREBPs. We show that hepatic SREBP-2 binds preferentially to two different gene-proximal motifs. A Gene Ontology (GO) analysis suggests SREBP-2 targets lipid metabolic processes as expected, but apoptosis and autophagy gene categories were also enriched. We show that SREBP-2 directly activates autophagy genes during cell-sterol depletion, conditions known to induce both autophagy and nuclear SREBP-2 levels. Additionally, SREBP-2 knockdown during nutrient depletion decreased autophagosome formation and lipid droplet association of the autophagosome targeting protein LC3. Thus, the lipid droplet could be viewed as a third source of cellular cholesterol, which along with sterol synthesis and uptake, is also regulated by SREBP-2.
Synopsis of Psychiatry: Behavioral Sciences, Clinical Psychiatry
Authors: Julia B. Frank
Journal: JAMA (1992)

<b>Study Guide and Self-Examination Review for Synopsis of Psychiatry and Comprehensive Textbook of Psychiatry</b>, by Harold I. Kaplan and Benjamin J. Sadock, 4thed, 442pp, ISBN0-683-04535-0, Baltimore, Md, Williams &amp; Wilkins, 1991. <b>Pocket Handbook of Clinical Psychiatry</b>, by Harold I. Kaplan and Benjamin J. Sadock, 335 pp, ISBN 0-683-04523-7, Baltimore, Md, Williams &amp; Wilkins, 1990. <b>Comprehensive Glossary of Psychiatry and Psychology</b>, by Harold I. Kaplan and Benjamin J. Sadock, 215 pp, paper $14.95, ISBN 0-683-04527-X, Baltimore, Md, Williams &amp; Wilkins, 1991. Other physicians have complained for years that psychiatrists speak an idiosyncratic and generally incomprehensible language that excludes them from the mainstream of medicine. The decline of psychoanalysis and the "remedicalization" of psychiatry have helped reopen the dialogue among psychiatrists, their patients, and their medical peers. Crucial to this process has been the availability of psychiatric textbooks that synthesize (or gloss over) the internal contradictions of current psychiatric theory and present
Size of Bile Salt Micelles: Techniques, Problems and Results
Authors: Josip P. Kratohvil
Journal: Hepatology (1984)

The current state of the knowledge of the size and the aggregation numbers of micelles formed in solutions of bile salts was evaluated. The experimental techniques considered include static light scattering, sedimentation equilibrium, membrane osmometry, sedimentation velocity and transla-tional diffusion. The theoretical background of each method is briefly discussed, the working equations are summarized, and the limitations of each technique are enumerated. Various interaction parameters and their effects on the measured micellar size are discussed. A brief survey of the recent experimental results from the author’s laboratory is presented.
Successful Surgical Treatment of a Symptomatic Myocardial Bridge
Authors: Antonios Ziakas, E. Moralidis, A. Parisiadou, D. Samanidi, S. Gavrilidis, G. Parharidis
Journal: Clinical Nuclear Medicine (2010)

A 57-year-old man with exertional chest pain underwent a positive study for myocardial ischemia on myocardial perfusion tomography. Coronary angiography revealed a long myocardial bridge in the midportion of the left anterior descending artery. The patient remained symptomatic with medical treatment. Surgical treatment was considered a better option because the diseased segment was a long, bare metal myocardial bridge stenting which has a higher restenosis rate compared with stenting of de novo atherosclerotic lesions, and data on drug-eluting myocardial bridge stenting is limited. The patient remained asymptomatic and had a normal myocardial perfusion tomography 12 months after surgery.
Pulmonary Vascular Effects of Lidocaine and Ganglionic and Adrenergic Blockers.
Authors: Albert L. Hyman
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Pulmonary Vascular Effects of Lidocaine and Ganglionic and Adrenergic Blockers.Albert L. Hyman, M.D., F.A.C.P.Albert L. Hyman, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-809_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough lidocaine, and ganglionic and adrenergic blockers are widely used in dire cardiopulmonary illness, the direct effects of these agents on pulmonary vasculature tone are poorly understood. Direct effects were obscured in previous studies by indirect effects resulting from simultaneous cardiac and peripheral actions of these agents. Both effects were studied simultaneously in intact dogs by catheter technics designed to perfuse a hemodynamically separated lobe at constant flows. A 20 F balloon catheter was passed into a lobar pulmonary artery, the balloon was distended, and the hemodynamically separated lobe was pump-perfused with aortic blood. Intrathoracic vascular pressures were obtained with... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, La. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 809-810KeywordsBloodCathetersPulmonary arteries Issue Published: 1 May 1970 PDF downloadLoading ...
<i>Crimson Autumn</i>
Authors: Thomas B. Cole
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inactivation of the Candidate Tumor Suppressor <i>Par-4</i> in Endometrial Cancer
Authors: Gema Moreno-Bueno, Pablo J. Fernandez-Marcos, Manuel Collado, Mercedes J. Tendero, Socorro M. Rodriguez-Pinilla, Isabel Garcia-Cao, David Hardisson, Maria T. Diaz-Meco, Jorge Moscat, Manuel Serrano, Jose Palacios
Journal: Cancer Research (2007)

Abstract Recently, it has been shown that mice deficient in the proapoptotic protein prostate apoptosis response 4 (Par-4) are specifically prone to develop endometrial carcinomas. Based on this, we have examined here the possible role of Par-4 as a tumor suppressor gene in human endometrial cancer. Using cDNA arrays, quantitative reverse transcription-PCR, and immunohistochemistry, we detected Par-4 down-regulation in ∼40% of endometrial carcinomas. This alteration was not associated with phosphatase and tensin homologue (PTEN), K-RAS, or β-catenin mutations, but was more frequent among tumors showing microsatellite instability (MSI) or among tumors that were estrogen receptor positive. Mutational analysis of the complete coding sequence of Par-4 in endometrial cancer cell lines (n = 6) and carcinomas (n = 69) detected a mutation in a single carcinoma, which was localized in exon 3 [Arg (CGA) 189 (TGA) Stop]. Interestingly, Par-4 promoter hypermethylation was detected in 32% of the tumors in association with low levels of Par-4 protein and was more common in MSI-positive carcinomas. Par-4 promoter hypermethylation and silencing was also detected in endometrial cancer cell lines SKUT1B and AN3CA, and reexpression was achieved by treatment with the demethylating agent 5′-aza-2′-deoxycytidine. Together, these data show that Par-4 is a relevant tumor suppressor gene in human endometrial carcinogenesis. [Cancer Res 2007;67(5):1927–34]
Use of Immunocytochemical Analysis of a Duodenal Biopsy Specimen to Identify a Carrier of Ornithine Transcarbamylase Deficiency
Authors: Yuji Hamano, Hiroko Kodama, Yasuhiro Fujikawa, Yoshiyuki Tanaka, Kazuhiko Nishimura, Masayoshi Yanagisawa
Journal: New England Journal of Medicine (1988)

DEFICIENCY of ornithine transcarbamylase (OTC, or ornithine carbamoyltransferase [EC 2.1.3.3]), a urea-cycle enzyme located in the mitochondrial matrix, is one of the most frequently inherited causes of ammonia intoxication, with inheritance following an X-linked dominant pattern. Recently, prenatal diagnosis of OTC deficiency has been achieved with use of DNA restriction-fragment–length polymorphisms (RFLPs) at the OTC locus.1 , 2 However, correct identification of women who are carriers of OTC deficiency is essential for accurate prenatal diagnosis because RFLP analysis does not identify a specific mutation at the OTC locus.Carriers of OTC deficiency have been identified by measuring urinary excretion of orotic acid . . .
Lack of Direct Role for Calcium in Ischemic Diastolic Dysfunction in Isolated Hearts
Authors: Franz R. Eberli, Hinrik Strömer, Margaret A. Ferrell, Niraj Varma, James P. Morgan, Stefan Neubauer, Carl S. Apstein
Journal: Circulation (2000)

Background —Ischemia is characterized by an increase in intracellular calcium and occurrence of diastolic dysfunction. We investigated whether the myocyte calcium level is an important direct determinant of ischemic diastolic dysfunction. Methods and Results —We exposed isolated, perfused isovolumic (balloon in left ventricle) rat and rabbit hearts to low-flow ischemia and increased extracellular calcium (from 1.5 to 16 mmol/L) for brief periods. Intracellular calcium was measured by aequorin. Low-flow ischemia resulted in a 270% increase ( P &lt;0.05) in diastolic intracellular calcium, a 50% ( P &lt;0.05) calcium transient amplitude decrease, and a 52% ( P &lt;0.05) slowing of calcium transient decline. Diastolic pressure increased by 6±2 mm Hg ( P &lt;0.05), and rate of systolic pressure decay decreased by 65% ( P &lt;0.05). Experimentally increasing extracellular calcium doubled both intracellular diastolic calcium and calcium transient amplitude, concomitant with a developed pressure increase; however, there was no increase in ischemic diastolic pressure, slowing of the calcium transient decay, or further slowing of systolic pressure decay. Similarly, after 45 minutes of low-flow ischemia, after diastolic pressure had increased from 8.5±0.6 to 19.7±3.5 mm Hg ( P &lt;0.001), intracoronary high-molar calcium chloride infusion increased systolic pressure from 36±4 to 63±11 mm Hg ( P &lt;0.001), indicating an increase in intracellular calcium, but it decreased diastolic pressure from 19.7±3.5 to 17.5±3.7 mm Hg ( P &lt;0.01). Conversely, EGTA infusion decreased systolic pressure, indicating a decrease in intracellular calcium, but did not decrease diastolic pressure. Conclusions —When calcium availability was experimentally altered during ischemia, there was no alteration in left ventricular diastolic pressure, suggesting that ischemic diastolic dysfunction is not directly mediated by a calcium activated tension.
Fifty Hours for the Poor-Reply
Authors: George D. Lundberg
Journal: JAMA (1990)

<h3>In Reply. —</h3> I appreciate the opportunity afforded by the publication of these letters to expand on the editorial entitled "Fifty Hours for the Poor" that we now have published in three consecutive Decembers.<sup>1-3</sup> An original purpose of this editorial was to copublish in the principal American professional journals of medicine and law on some subject that representatives of these two great old learned professions could agree on (rather than continue our well-known posture of fighting). In this we succeeded. Subsequent to the initial publication, the American Bar Association made the title of the editorial its official policy.<sup>4</sup>The then President of the American Medical Association, James E. Davis, made service the theme of his term and expanded the charge to 4 hours per week, adding the option of community volunteerism in addition to patient care.<sup>5</sup>The American Medical Association's Board of Trustees then established the annual
Pathogenesis of holoprosencephaly
Authors: Xin Geng, Guillermo Oliver
Journal: Journal of Clinical Investigation (2009)

Holoprosencephaly (HPE), the most common human forebrain malformation, occurs in 1 in 250 fetuses and 1 in 16,000 live births. HPE is etiologically heterogeneous, and its pathology is variable. Several mouse models of HPE have been generated, and some of the molecular causes of different forms of HPE and the mechanisms underlying its variable pathology have been revealed by these models. Herein, we summarize the current knowledge on the genetic alterations that cause HPE and discuss some important questions about this disease that remain to be answered.
Granulocytosis and a Sulindac Overdose
Authors: GARY E. GROSS
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 June 1982Granulocytosis and a Sulindac OverdoseGARY E. GROSS, M.D.GARY E. GROSS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-6-793_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sulindac (Clinoril; Merck, Sharp & Dohme, West Point, Pennsylvania) is a nonsteroidal anti-inflammatory indene derivative that has gained increasing acceptance in the treatment of meumatoid arthritis and other inflammatory conditions since its introduction in 1977 (1). Bone marrow aplasia and secondary cytopenias have been associated with the use of sulindac (1-2) but granulocytosis associated with this drug has not been reported. We present the following case of acute, extreme, and rapidly reversible granulocytosis associated with an overdose of sulindac.A 16-year-old boy was admitted to the hospital on 14 February 1982 for observation and treatment for an...References1. MILLER J. Marrow aplasia and sulindac [Letter]. Ann Intern Med. 1980;92:129. LinkGoogle Scholar2. BENNETTSCHLOSSMANROSENTHALBALZORABENNETTROSNER LRJJAF. Aplastic anemia and sulindac [Letter]. Ann Intern Med. 1980;92:874. LinkGoogle Scholar3. MARSHALMEYDALEVY FJI. Nonthrombocytopenic purpura and acute glomerulonephritis after indocin therapy. Ann Rheum Dis. 1971;30:501-5. CrossrefMedlineGoogle Scholar4. GAYLORCHERVENICKBOGGS MPD. Neutrophil kinetics after acute hemorrhage. Proc Soc Exp Biol Med. 1969;131:1332-6. CrossrefMedlineGoogle Scholar5. BISHOPATHENSBOGGSWARNERCARTWRIGHTWINTROBE CJDHGM. A non-steady state kinetic evaluation of the mechanism of cortisone induced granulocytosis. J Clin Invest. 1968; 47:249. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Texas Health Science Center at San Antonio San Antonio, TX 78284 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNonsteroidal Anti-Inflammatory DrugsNonsteroidal Anti-inflammatory DrugsSulindacNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)SulindacAcute Poisoning Due to Non-Steroidal Anti-Inflammatory DrugsAntiinflammatory analgesics and durgs used in rheumatoid arthritis and gout 1 June 1982Volume 96, Issue 6_Part_1Page: 793-794KeywordsBone marrowDrugsInflammatory arthritis Issue Published: 1 June 1982 PDF DownloadLoading ...
Prevention of the Wernicke-Korsakoff Syndrome
Authors: Brandon S. Centerwall, Michael H. Criqui
Journal: New England Journal of Medicine (1978)

The Wernicke-Korsakoff syndrome is a thiamine-deficiency disorder occurring primarily among alcoholics. To determine the economic feasibility of preventing this disease by fortification of alcoholic beverages with thiamine, we compared the cost of fortification with the cost of institutionalizing alcoholics with the disorder. The estimated annual incidence of institutionalization is eight per million adult population. The cost of long-term institutionalization, discounted to present value, is $70 million per year. The cost of adequately fortifying alcoholic beverages is estimated to range from $3 million per year if allithiamines are used, to as much as $17 million per year if thiamine hydrochloride proves necessary. Thus, the cost-benefit ratio may range from 1:23 to 1:4. It is economically advantageous to prevent the Wernicke-Korsakoff syndrome by fortification of alcoholic beverages with thiamine. The stability, safety and marketability of thiamine and the allithiamines in alcoholic beverages should be studied further.
Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes
Authors: Azim Mohamedali, Joop Gäken, Natalie A. Twine, Wendy Ingram, Nigel Westwood, Nicholas C. Lea, Janet Hayden, Nora Donaldson, Carlo Aul, Norbert Gattermann, Aristotle Giagounidis, Ulrich Germing, Alan F. List, Ghulam J. Mufti
Journal: Blood (2007)
Risk of breast cancer in relation to the interval since last full term pregnancy
Authors: P Cumming, J L Stanford, J R Daling, N S Weiss, B McKnight
Journal: BMJ (1994)

To examine whether the risk of breast cancer is increased by a recent term pregnancy.Population based case-control study.Eight areas in the United States.Cases were 2279 multiparous women residents of the eight areas aged 25-49 who were diagnosed as having breast cancer during 1980-2. Controls were 2357 multiparous women selected from the same areas by random digit dialing.Relative risk of developing breast cancer according to the time interval since last full term pregnancy.The distribution of intervals since the last term pregnancy was similar in cases and controls. Adjusted for age, parity, and age at first term pregnancy, the odds ratios observed for categories of years since the last full term pregnancy were: 0-2 years, odds ratio 1.16 (95% confidence interval 0.84 to 1.59); 3-6 years, odds ratio 1.21 (0.95 to 1.54); 7-9 years, odds ratio 1.04 (0.84 to 1.38); > or = 10 years, odds ratio 1.00 (reference).Among multiparous women aged 25-49 years there was no association between the risk of breast cancer and the time interval since the last full term pregnancy.
The Park Nicollet Experience
Authors: Michael J. Dawson
Journal: Annals of Internal Medicine (1999)

Letters16 November 1999The Park Nicollet ExperienceMichael J. Dawson, MDMichael J. Dawson, MDWest Allis, WI 53227 (Dawson)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Having just read the supplement on hospitalists, I am still confused about the place of the hospitalist. Despite little more than anecdotal data on the effectiveness of hospitalist programs, there is an ongoing trend for support of these programs. The impetus seems to be a desire to control costs, although some have mentioned that general internists can no longer manage medical inpatients. This is sad and unfortunate.The discontinuity of care and disruption of the physician–patient relationship are the most troubling part of this equation. Surveys reporting patient satisfaction with the hospitalist system do not indicate whether ...References1. Freese RB. The Park Nicollet experience in establishing a hospitalist system. Ann Intern Med. 1999; 130(2 pt 2):350-4. Google Scholar2. Craig DE, Hartka L, Likosky WH, Caplan WM, Litsky P, Smithey J. Implementation of a hospitalist system in a large health maintenance organization: the Kaiser Permanente experience. Ann Intern Med. 1999; 130(2 pt 2):355-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: West Allis, WI 53227 (Dawson) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Park Nicollet Experience in Establishing a Hospitalist System Richard B. Freese Implementation of a Hospitalist System in a Large Health Maintenance Organization: The Kaiser Permanente Experience Diane E. Craig , Liz Hartka , William H. Likosky , William M. Caplan , Paul Litsky , and Jannalee Smithey The Park Nicollet Experience Richard B. Freese Metrics 16 November 1999Volume 131, Issue 10Page: 792KeywordsHealth care utilizationHealth surveysHospitalistsInpatientsMedical educationOutpatientsPhysiciansPrimary care physicians Issue Published: 16 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Unsuspected Parotid Tumors
Authors: Harold M. Griffiths
Journal: JAMA (1970)

During a recent six-year period, 33 patients with parotid tumors, 15 of which were malignant, were treated at the Indiana University Medical Center, Indianapolis. Eight patients presented with a history of prior minor surgical procedures, and among these, four had tumors which were malignant. Once a logical index of suspicion is established, errors of this type in the initial management of these lesions can be avoided. A brief resume of eight cases is presented.