tbuckley/cabot-search huggingface dataset:
Elevated Whole-Blood Tissue Factor Procoagulant Activity as a Marker of Restenosis After Percutaneous Transluminal Coronary Angioplasty and Stent Implantation
Authors: Eralp Tutar, Muhit Ozcan, Mustafa Kilickap, Sadi Gülec, Omer Aras, Gulgun Pamir, Dervis Oral, Luke Dandelet, Nigel S. Key
Journal: Circulation (2003)

Experimental data suggest that tissue factor (TF) may induce neointimal hyperplasia after arterial injury. In this study, we investigated the hypothesis that elevated levels of TF in the circulation contribute to the development of restenosis after percutaneous transluminal coronary angioplasty (PTCA) or stent implantation.Whole-blood TF procoagulant activity (TF-PCA) was measured using a previously described assay before, at 3 hours after, and at 24 hours after the intervention in 61 patients with stable angina undergoing PTCA (n=20) or stent implantation (n=41). Coronary angiography was performed 4 to 6 months after the intervention, and luminal narrowing > or =50% was defined as restenosis. Whole-blood TF-PCA levels did not correlate with intracellular monocyte tumor necrosis factor-alpha expression, a marker of activation of these cells. Baseline levels and time course of whole-blood TF-PCA after the intervention were compared in patients who did or did not subsequently develop restenosis. Whole-blood TF-PCA levels did not change significantly in the 24 hours after either intervention. However, in both the PTCA and stent groups, initial TF-PCA was significantly higher in patients who subsequently developed restenosis (P=0.018 and 0.039 compared with those who did not develop restenosis for PTCA and stent groups, respectively).Higher baseline values of whole-blood TF-PCA may be a predictor of restenosis after PTCA and stent implantation.
Suppression of VEGF by Reversible‐PEGylated Histidylated Polylysine in Cancer Therapy
Authors: Xiaojun Cai, Haiyan Zhu, Haiqing Dong, Yongyong Li, Jiansheng Su, Donglu Shi
Journal: Advanced Healthcare Materials (2014)

A reversible‐PEGylated polylysine is designed and developed for efficient delivery of siRNA. In this unique structure, the ε ‐amino groups of disulfide linked poly(ethylene glycol) (PEG) and polylysine (mPEG‐SS‐PLL) are partially replaced by histidine groups, in order to develop the histidylated reversible‐PEGylated polylysine (mPEG‐SS‐PLH), for enhanced endosome escape ability. The transfection efficacy of mPEG‐SS‐PLH is found to closely correlate with histidine substitution. Its maximum transfection efficiencies are determined, respectively, to be 75%, 42%, and 24%, against 293T, MCF‐7, and PC‐3 cells. These data indicate that the transfection efficiencies can equal or even outweigh PEI‐25k in the corresponding cells (80%, 38.5%, and 20%). The in vivo circulation and biodistribution of the polyplexes are monitored by fluorescent imaging. The in vivo gene transfection is carried out by intravenous injection of pEGFP to BALB/c mice using the xenograft models. The in vivo experimental results show effective inhibition of tumor growth by mPEG‐SS‐PLH/siRNA–VEGF, indicating its high potential for clinical applications.
Sjögren's Syndrome and Mononeuritis Multiplex
Authors: E. WAYNE MASSEY
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 January 1980Sjögren's Syndrome and Mononeuritis MultiplexE. WAYNE MASSEY, M.D.E. WAYNE MASSEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-130_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The predominantly sensory and characteristically mild, distal, symmetrical polyneuropathy occurring with Sjögren's syndrome was reviewed in your journal in 1969 (1). Mononeuritis multiplex has been associated with collagen vascular disorders, sarcoidosis, diabetes mellitus, infectious mononucleosis, leprosy, and primary macroglobulinemia (2). The following is a case of mononeuritis multiplex occurring in Sjögren's syndrome.A 54-year-old woman with a 10-year history of xerostomia, xeroophthalmia, and Raynaud's phenomena had been experiencing intermittent numbness in both hands at night for years. More recently she had had difficulty opening jars and turning knobs with her right hand. Bilateral lateral thigh numbness had...References1. KALTREIDER H and TALAL N. The neuropathy of Sjögren's syndrome. Ann Intern Med. 1969;70:751-62. LinkGoogle Scholar2. MASSEY E, PLEET A, and BRANNON W. Waldenström's macroglobulinemia and mononeuritis multiplex. Ann Intern Med. 1978;88:360-1. LinkGoogle Scholar3. ATTWOOD W and POSER C. Neurologic complications of Sjögren's syndrome. Neurology (Minneap). 1961;11:1034-6. CrossrefMedlineGoogle Scholar4. WEBER F. Sjögren's syndrome, especially its non-ocular features. Br J Ophthalmol. 1945;29:299-309. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: E. WAYNE MASSEY, M.D.Affiliations: Duke University Medical Center Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeripheral nervous system involvement complicated due to vasculitis in cases of primary Sjögren's syndrome: case studies in a single hospital and a literature review 1 January 1980Volume 92, Issue 1Page: 130-130KeywordsDiabetes mellitusLeprosyMononeuritisSarcoidosis ePublished: 1 December 2008 Issue Published: 1 January 1980 PDF downloadLoading ...
Pulmonary reactions to organic dust exposures: development of an animal model.
Authors: V Castranova, V A Robinson, D G Frazer
Journal: Environmental Health Perspectives (1996)

Acute inhalation of organic dusts such as cotton, hay, silage, grain, animal confinement, or compost dust can result in illness characterized by fever, pulmonary inflammation, chest tightness, and airway obstruction. These agricultural materials are complex mixtures of plant, bacterial, and fungal products. Elucidation of the time course of disease onset, the mechanisms of disease progression, and the identity of etiologic agents is essential for effective prevention and treatment. Toward this end, animal models for acute organic dust-induced reactions have been developed and characterized. Information concerning the applicability of various animal models to humans and progress toward elucidation of causative agents and mechanisms of action is presented.
ACTH-Responsive, Dexamethasone-Suppressible Adrenocortical Carcinoma
Authors: Elliot J. Rayfield, Leslie I. Rose, John P. Cain, Robert G. Dluhy, Gordon H. Williams
Journal: New England Journal of Medicine (1971)

ADRENOCORTICAL neoplasms are not thought to be adrenocorticotrophin (ACTH) dependent since they fail to show suppression of 17-hydroxycorticosteroids (17-OHCS) with the administration of 8 mg of dexamethasone per 24 hours.1 Recently, Kendall and Sloop2 described a patient with an adrenocortical adenoma in whom 2 mg of dexamethasone per 24 hours suppressed urinary 17-OHCS excretion from 18 to 3.5 mg per 24 hours. The following report describes a patient with a metastatic adrenocortical carcinoma that physiologically mimicked adrenocortical hyperplasia.Case ReportEight months after right nephroadrenalectomy for adrenocortical "adenoma" with Cushing's syndrome a 70-year-old woman was admitted to the Clinical Center . . .
Holmium Laser Enucleation of the Prostate Versus Open Prostatectomy for Prostates &gt;70g: 24-Month Follow-up
Authors: Richard Naspro, Nazareno Suardi, Andrea Salonia, Vincenzo Scattoni, Giorgio Guazzoni, Renzo Colombo, Andrea Cestari, Alberto Briganti, Bruno Mazzoccoli, Patrizio Rigatti, Francesco Montorsi
Journal: European Urology (2006)
Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth
Authors: Syng-Ook Lee, Maen Abdelrahim, Kyungsil Yoon, Sudhakar Chintharlapalli, Sabitha Papineni, Kyounghyun Kim, Huamin Wang, Stephen Safe
Journal: Cancer Research (2010)

Abstract Activation of the orphan nuclear receptor TR3/Nur77 (NR4A1) promotes apoptosis and inhibits pancreatic tumor growth, but its endogenous function and the effects of its inactivation have yet to be determined. TR3 was overexpressed in human pancreatic tumors compared with nontumor tissue. Small interfering RNA–mediated knockdown of TR3 or cell treatment with the TR3 antagonist 1,1-bis(3′-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) decreased proliferation, induced apoptosis, and decreased expression of antiapoptotic genes including Bcl-2 and survivin in pancreatic cancer cells. Survivin suppression was mediated by formation of a TR3-Sp1-p300 DNA binding complex on the proximal GC-rich region of the survivin promoter. When administered in vivo, DIM-C-pPhOH induced apoptosis and inhibited tumor growth in an orthotopic model of pancreatic cancer, associated with inhibition of the same antiapoptotic markers observed in vitro. Our results offer preclinical validation of TR3 as a drug target for pancreatic cancer chemotherapy, based on the ability of TR3 inhibitors to block the growth of pancreatic tumors. Cancer Res; 70(17); 6824–36. ©2010 AACR.
Endoscopic Management of Pancreaticopleural Fistulas: A Report of Three Patients
Authors: T. Koshitani, Y. Uehara, T. Yasu, Y. Yamashita, T. Kirishima, N. Yoshinami, J. Takaaki, H. Shintani, K. Kashima, H. Ogasawara, Y. Katsuma, T. Okanoue
Journal: Endoscopy (2006)

Pancreaticopleural fistulas are a rare complication of acute or chronic pancreatitis, and are usually treated by surgery. We report three patients whose pancreaticopleural fistulas were successfully treated by endoscopic retrograde cholangiopancreatography and drainage (stenting, nasopancreatic drainage). In one patient a pancreatic pseudocyst persisted despite successful initial closure of the leak using this method and, as it was also suspected to be infected, additional drainage of the pseudocyst was required. Endotherapy of pancreaticopleural fistulas could obviate the need for surgery when conventional medical treatment has failed in this condition.
Aspirin for primary prevention of vascular disease in people with diabetes
Authors: R. Haynes, L. Bowman, J. Armitage
Journal: BMJ (2009)

Balance of benefits versus risks is currently unclear

Diabetes is a major global public health problem—by 2025 an estimated 300 million people worldwide will be affected.1 With the associated twofold to fourfold increased risk of cardiovascular disease, more than half of these people will die prematurely from vascular events.2 Treatments that lower lipids, blood pressure, and glucose all reduce the risk of cardiovascular disease safely (preventing first and subsequent events), but even with effective treatment patients with diabetes are at high risk.3 4 5 Further treatments are therefore needed to reduce this risk. In the linked meta-analysis (doi:10.1136/bmj.b4531), De Berardis and colleagues assess the benefits and harms of low dose aspirin in people with diabetes and no cardiovascular disease.6 

Because most people with diabetes live in low and middle income countries, such treatments should ideally be inexpensive as well as safe and effective. Aspirin is cheap, widely available, and recommended (and taken) to reduce the risk of recurrent events for people (including those with diabetes) who have survived a vascular event or …
Plasma Acetone Metabolism in the Fasting Human
Authors: G. A. Reichard, A. C. Haff, C. L. Skutches, P. Paul, C. P. Holroyde, O. E. Owen
Journal: Journal of Clinical Investigation (1979)

The metabolism of acetone was studied in lean and obese humans during starvation ketosis. Acetone concentrations in plasma, urine, and breath; and rates of endogenous production, elimination in breath and urine, and in vivo metabolism were determined. There was a direct relationship between plasma acetone turnover (20-77 μmol/m2 per min) and concentration (0.19-1.68 mM). Breath and urinary excretion of acetone accounted for a 2-30% of the endogenous production rate, and in vivo metabolism accounted for the remainder. Plasma acetone oxidation accounted for ≅60% of the production rate in 3-d fasted subjects and about 25% of the production rate in 21-d fasted subjects. About 1-2% of the total CO2 production was derived from plasma acetone oxidation and was not related to the plasma concentration or production rate. Radioactivity from [14C]acetone was not detected in plasma free fatty acids, acetoacetate, β-hydroxybutyrate, or other anionic compounds, but was present in plasma glucose, lipids, and proteins. If glucose synthesis from acetone is possible in humans, this process could account for 11% of the glucose production rate and 59% of the acetone production rate in 21-d fasted subjects. During maximum acetonemia, acetone production from acetoacetate could account for 37% of the anticipated acetoacetate production, which implies that a significant fraction of the latter compound does not undergo immediate terminal oxidation.
Multiple-Lead Exercise Electrocardiography
Authors: ROBERT E. MASON, IVAN LIKAR, ROBERT O. BIERN, RICHARD S. ROSS
Journal: Circulation (1967)

A system of multiple-lead exercise electrocardiography has been applied to the study of 107 normal subjects and 67 patients with angina pectoris. The results of this test are compared to those of coronary cinearteriography in 84 patients. In-exercise ECGs gave useful additional information in 59% of the angina patients but were essential for interpretation in 9%. It added considerably to the safety of the test. The value of each individual lead and of the multiple lead system was assessed. Lead V 6 was the most often positive, but each made a contribution in some cases. Test-retest reproducibility survey indicated that five of 65 tests on 25 subjects failed to conform. Evidence has been presented that 1.0 mm of ischemic S-T segment shift was the best criterion for a positive test in the subjects studied. The test was positive in 84% of 67 patients with angina pectoris and 3.7% of 107 normal subjects (excluding vasoregulatory hyperreactors). The double two-step test given to the first 41 of the same angina patients for comparison was found to give 61% positive reactions despite the use of multiple leads and in-exercise recording. The test was administered to 84 subjects who were studied concurrently by selective coronary cinearteriograms and these two parameters were compared with the clinical diagnosis of angina in each patient. Since each of these parameters represents a different facet of coronary arterial disease, the agreement among them is very instructive.
Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor
Authors: Tsutomu Fujii, Katsumi Koshikawa, Shuji Nomoto, Osamu Okochi, Tetsuya Kaneko, Soichiro Inoue, Yasushi Yatabe, Shin Takeda, Akimasa Nakao
Journal: Journal of Hepatology (2004)
Efficacy and safety of endoscopic submucosal dissection for gastric cancer in patients with liver cirrhosis
Authors: K. Ogura, M. Okamoto, T. Sugimoto, N. Yahagi, M. Fujishiro, N. Kakushima, S. Kodashima, T. Kawabe, M. Omata
Journal: Endoscopy (2008)

Endoscopic submucosal dissection (ESD) has become a widely accepted method for treating gastrointestinal cancer. The aim of this study was to evaluate the efficacy and safety of ESD for gastric cancer in patients with liver cirrhosis. A total of 18 gastric cancers were treated by ESD in 15 patients with cirrhosis. The rate of en bloc resection was 88.9 % (16/18). En bloc resection with tumor-free lateral/basal margins (R0 resection) was 77.8 % (14/18). Three patients had postoperative bleeding and underwent emergency gastroscopy for hemostasis. No recurrence was observed during the median follow-up of 21.4 months, excluding three patients in whom additional endoscopic resection or surgery was carried out. ESD can be safely performed for gastric cancer in patients with cirrhosis, resulting in a high en bloc resection rate.
Joint crisis plans for people with psychosis: economic evaluation of a randomised controlled trial
Authors: Chris Flood, Sarah Byford, Claire Henderson, Morven Leese, Graham Thornicroft, Kim Sutherby, George Szmukler
Journal: BMJ (2006)

<h3>Abstract</h3> <b>Objective</b> To investigate the cost effectiveness of joint crisis plans, a form of advance agreement for people with severe mental illness. <b>Design</b> Single blind randomised controlled trial. <b>Setting</b> Eight community mental health teams in southern England. <b>Participants</b> 160 people with a diagnosis of psychotic illness or non-psychotic bipolar disorder who had been admitted to hospital at least once within the previous two years. <b>Intervention</b> Joint crisis plan formulated by the patient, care coordinator, psychiatrist, and project worker containing contact information, details of illnesses, treatments, relapse indicators, and advance statements of preferences for care for future relapses. Control group was standardised service information. <b>Main outcome measures</b> Admission to hospital; service use over 15 months. <b>Results</b> Use of a joint crisis plan was associated with less service use and lower costs on average than in the standardised service information group, but differences were not significant. Total costs during follow-up were £7264 (€10 616, $13 560) for each participant with a joint crisis plan and £8359 (€12 217, $15 609) for each participant with standardised service information (mean difference £1095; 95% confidence interval −2814 to 5004). Cost effectiveness acceptability curves, used to explore uncertainty in estimates of costs and effects, suggest there is a greater than 78% probability that joint crisis plans are more cost effective than standardised service information in reducing the proportion of patients admitted to hospital. <b>Conclusion</b> Joint crisis plans produced a non-significant decrease in admissions and total costs. Though the cost estimates had wide confidence intervals, the associated uncertainty suggests there is a relatively high probability of the plans being more cost effective than standardised service information for people with psychotic disorders.
Workgroup Report: Biomonitoring Study Design, Interpretation, and Communication—Lessons Learned and Path Forward
Authors: Michael N. Bates, Joshua W. Hamilton, Judy S. LaKind, Patricia Langenberg, Michael O’Malley, Wayne Snodgrass
Journal: Environmental Health Perspectives (2005)

Human biomonitoring investigations have provided data on a wide array of chemicals in blood and urine and in other tissues and fluids such as hair and human milk. These data have prompted questions such as a) What is the relationship between levels of environmental chemicals in humans and external exposures? b) What is the baseline or "background" level against which individual levels should be compared? and c) How can internal levels be used to draw conclusions about individual and/or population health? An interdisciplinary panel was convened for a 1-day workshop in November 2004 with the charge of focusing on three specific aspects of biomonitoring: characteristics of scientifically robust biomonitoring studies, interpretation of human biomonitoring data for potential risks to human health, and communication of results, uncertainties, and limitations of biomonitoring studies. In this report we describe the recommendations of the panel.
Codfish allergy in adults Identification and diagnosis
Authors: T. K. Hansen, C. Bindslev‐Jensen
Journal: Allergy (1992)

Ten adult patients with a medical history of immediate allergic reactions following ingestion of minute amounts of codfish were examined together with 27 control subjects (8 nonatopics, 7 pollen allergies, and 12 suffering from atopic dermatitis) all regularly ingesting codfish without experiencing reactions. All 37 subjects were evaluated by skin prick test, RAST, and histamine release test in order to determine the value of these commonly used diagnostic tests. The results were compared to titrated, oral, double‐blind, placebo‐controlled food challenges (DBPCFCs) with fresh codfish undertaken in the 10 patients, whereas all control subjects were classified as challenge‐negative according to their questionnaires. Totally, 7 of 10 medical histories were confirmed by DBPCFC, and in these most of the reported symptoms proved reproducible. Oropharyngeal itching and swelling occurred as the first symptom, always preceding the onset of any accompanying symptom. For identification of DBPCFC‐positive subjects, skin prick test and RAST proved to be the most sensitive tests (7/7), and all tests showed specificities of 90–97%. The skin prick test still seems reliable but does not, however, exclude the need for DBPCFC.
Changes Over Time in the Knowledge Base of Practicing Internists
Authors: Paul G. Ramsey, Jan D. Carline, Thomas S. Inui, Eric B. Larson, James P. LoGerfo, John J. Norcini, Marjorie D. Wenrich
Journal: JAMA (1991)

To determine factors affecting the knowledge base of practicing internists.An 82-item multiple-choice examination with questions from the 1988 American Board of Internal Medicine (ABIM) certifying examination was used to assess the knowledge base of 289 internists.Participants were selected from among practicing internists in New York, New Jersey, and Pennsylvania who had received ABIM certification 5 to 15 years previously.significant inverse correlation (r = -.30) was found between examination scores and the number of years elapsed since certification. Knowledge declined sharply within 15 years of certification. In addition, procedure-oriented subspecialists (cardiologists and gastroenterologists) had lower scores than other internists in this examination of general medical knowledge. Multivariate analyses showed that independent variables that predicted test performance were initial ABIM certifying examination score, time elapsed since certification, subspecialty classification, medical school type, and residency type.These results support the recent decision for time-limited certification of internists and raise questions related to content and standard setting for recertification examinations.
Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
Authors: Anuhar Chaturvedi, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, Haiyang Yun, Kerstin Görlich, Martin Wichmann, Adrian Schwarzer, Matthias Preller, Felicitas Thol, Johann Meyer, Reinhard Haemmerle, Eduard A. Struys, Erwin E. Jansen, Ute Modlich, Zhixiong Li, Laura M. Sly, Robert Geffers, Robert Lindner, Dietmar J. Manstein, Ulrich Lehmann, Jürgen Krauter, Arnold Ganser, Michael Heuser
Journal: Blood (2013)
MOVEMENTS OF THE VOCAL APPARATUS DURING AUDITORY HALLUCINATIONS
Authors: BERTRAM H. ROBERTS, MILTON GREENBLATT, HARRY C. SOLOMON
Journal: American Journal of Psychiatry (1952)

The occurrence of 43 reports of auditory hallucinations were accompanied by 19 instances of muscle activity to a moderate to marked degree (grades 2 and 3). There were only 4 instances in which the activity was coincident with the report of a hallucination, as indicated in Table 1.[SEE SOURCE PDF FOR TABLE 1.] Although bursts of muscle activity are occasionally seen from muscles of vocalization coinciding with auditory hallucinations reported by psychotic patients, such hallucinations are not consistently accompanied by vocal myographic discharges.
Genotypically nonidentical related donors for transplantation of patients with myelodysplastic syndromes: comparison with unrelated donor transplantation and autologous stem cell transplantation
Authors: T de Witte, F Pikkemaat, J Hermans, A van Biezen, S Mackinnan, J Cornelissen, A Gratwohl, M Delforge, A Iriondo, M Kuentz, J Harousseau, A Fauser, H Wandt, V Runde, D Niederwieser, J Apperley
Journal: Leukemia (2001)
A Newly Modified Electromagnetic Blood Flowmeter Capable of High Fidelity Flow Registration
Authors: ALFRED W. RICHARDSON, ADAM B. DENISON, HAROLD D. GREEN
Journal: Circulation (1952)

This paper describes a meter which, when inserted into an artery or vein, is capable of measuring the average flow, or the "instantaneous" flow throughout the heart cycle. Flow is recorded with a direct-writing instrument.