tbuckley/cabot-search huggingface dataset:
Keratin expression in pilosebaceous epithelia in truncal skin of acne patients
Authors: B.R. HUGHES, C. MORRIS, W.J. CUNLIFFE, I.M. LEIGH
Journal: British Journal of Dermatology (1996)

This study compared the pattern of keratin expression in pilosebaceous follicles in uninvolved trunk skin of acne patients, comedones, and normal control skin by immunohistochemistry, using both immunofluorescent (IF) and immunoperoxidase (IP) techniques. The shape, size and gross morphology of truncal follicles varied greatly. There was no difference in keratin expression between normal skin and uninvolved skin of patients with acne. The upper part of the pilosebaceous duct expressed keratins K1, K5, K10 and K14, whereas the lower duct expressed keratins K5, K6, K14, K16, K17 and K19. The sebaceous gland showed considerable heterogeneity in keratin expression, with some lobules expressing keratins K1, K5, K7, K10, K14 and K17. The comedone wall showed a pattern of keratin expression similar to that of the upper follicle, except that there was, in addition, expression of keratins K6 and K16 suprabasally, and panepithelial expression of K17 in the comedone wall. IF techniques were found to be less sensitive than the IP method in the detection of individual keratins, but the use of multiple antibodies and many different transverse and longitudinal sections of follicles permitted full conclusions to be made. The increased expression of keratins K6, K16 and K17 in the comedone wall is likely to represent a secondary effect of increased cell turnover due to the primary underlying mechanism of comedogenesis, which is as yet unknown.
SARCOMA OF THE CHOROID, A SERIES OF CASES.
Authors: GEORGE F. FISKE
Journal: JAMA (1896)

Case 1.  —M. E. B., architect, age 50, presented himself April 3, 1888, complaining of a cloud in the right eye which followed a severe attack of catarrhal fever three weeks before.  O. D. 36 in. Sph., 42 in. Cyl., 90 deg. 5-5 Sz.  O. D. 48 in. Sph., 18 in. Cyl., 90 deg. 5-6 Sz.  In the left eye there were several choroidal plaques in the upper outer periphery, and floating opacities in the vitreous. In the right eye separation of the retina on middle nasal side, extending within 2 mm. of the papilla. Nothing to distinguish it from ordinary separation of the retina. No suspicion of tumor.  Patient gave a history of very close application and was in a highly nervous state. Consultation was had with two other specialists, with no thought of sarcoma. Patient stopped work for two weeks, protected the eyes from light, wore a bandage
Future Development of Chinese Medical Journals
Authors: TSUNG O. CHENG
Journal: Annals of Internal Medicine (1973)

Editorial Notes1 December 1973Future Development of Chinese Medical JournalsTSUNG O. CHENG, M.D., F.A.c.P.TSUNG O. CHENG, M.D., F.A.c.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-6-897_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn my editorial note in the May 1973 issue (1) I promised to give a follow-up report on developments in Chinese medical journals. I have just returned from my second trip to the People's Republic of China where I spent a month and a half as the guest of the Chinese Medical Association, and I can report that the long-awaited English edition of theChinese Medical Journalwill make its debut this year or early next year. Like its Chinese counterpart, it will have 64 pages of medical texts and 8 pages of illustrations. The English edition will not be...Reference1. CHENG T: The new Chinese Medical Journal. Ann Intern Med 78:771-772, 1973 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcupuncture anesthesia for open heart surgery: Past, present and futureChinese journals: a guide for epidemiologistsMedical Education and Practice in People's Republic of ChinaTSUNG O. CHENG, M.D., F.A.C.P., LLOYD AXELROD, M.D., ALEXANDER LEAF, M.D., F.A.C.P. 1 December 1973Volume 79, Issue 6Page: 897-898KeywordsChinese peopleForecasting Issue Published: 1 December 1973 PDF DownloadLoading ...
Psoriasis and its treatment.
Authors: R H Champion
Journal: BMJ (1981)

At late stages of median nerve entrapment in the carpal tunnel there may be total denervation of the thenar muscles. Surface electrodes over the thenar endplate zone may record an initial and predominantly positive "M" response to supramaximal median nerve stimulation. By a combination of techniques, it has been established that this surface positive response originates from surviving lumbrical muscles innervated by the median nerve. Their relative preservation may be related to their location in the median nerve. Intraoperative investigations have shown that the thenar motor fibres are primarily located in the ventral-lateral part of the median nerve whereas lumbrical motor fibres are in a more dorsal location and hence are probably better protected against the flexor retinaculum. This relative preservation of lumbrical motor fibres has been observed in other peripheral neuropathies and motor neuron disease, but not in median nerve regeneration of the following nerve transection. The importance of the observation lies in the more precise localisation voltage source for "M" response in terminal or near-terminal carpal tunnel median nerve entrapments and avoidance thereby of possible misinterpretation of electrophysiological observations in this most common nerve entrapment syndrome.
Stimulation of calcium transport by amiloride in mouse distal convoluted tubule cells
Authors: Peter A. Friedman, Frank A. Gesek
Journal: Kidney International (1995)

This study examined the mechanism by which amiloride dissociates Na and Ca transport in distal convoluted tubules. Control rates of Na uptake averaged 288 nmol/(min mg protein) and were inhibited 39% by microM amiloride. Amiloride had no effect on Cl uptake. Resting membrane voltage, measured with the voltage-sensitive dye DiOC6 (3), averaged -70 mV. Amiloride hyperpolarized cells in a reversible manner by 18 mV. Control rates of Ca uptake averaged 2.8 nmol/(min mg protein) and increased by 39% in the presence of amiloride. Alterations of intracellular Ca activity were measured in single cells loaded with Fura2-AM. Control intracellular Ca activity averaged 100 nM. Amiloride increased intracellular Ca activity in a concentration-dependent manner to a maximum of 330 nM at microM amiloride. Amiloride analogues ethylisopropyl amiloride (EIPA) and dimethylbenzamil (DMB), which preferentially block Na/H and Na/Ca exchange, respectively, had no effect on Na or Ca influx or on intracellular Ca activity. The dihydropyridine Ca channel blocker nifedipine inhibited amiloride-stimulated Ca uptake and the rise of intracellular Ca activity but had no effect on membrane voltage. It is concluded that amiloride blocks Na entry mediated by Na channels. Inhibition of Na entry results in membrane hyperpolarization, which activates Ca entry by dihydropyridine-sensitive Ca channels.
Effect of Iopanoic Acid on the Sulfobromophthalein Test
Authors: Ralph R. Meyer
Journal: JAMA (1965)

Twenty-two of 24 healthy subjects showed an elevation of sulfobromophthalein (BSP) levels following ingestion of iopanoic acid (Telepaque); six of the readings were abnormal. Our data suggest that there is competition for excretion of iopanoic acid and BSP, which results in false elevation of BSP readings. To avoid errors in the diagnosis of liver disease, it is recommended that the BSP test and cholecystography not be performed concomitantly.
A paper that changed my practice: A lesson in time management
Authors: E. Ristinen
Journal: BMJ (1997)

In the 1950s, when I was a student at Harvard University, long before I embarked on a medical career, I read the women's pages in the Boston Globe regularly. The section was devoted to homemaking and was chockful of news, articles, and advice about housekeeping, meal preparation, childcare, and gardening. One piece of advice that I found there, and started to implement immediately, was the principle of “15 minutes a day.”

Housewives who despaired of ever getting …
"status post head trauma
Authors: Richard Donze
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigation, Explanation, and Apology for Incomplete and Erroneous Disclosures
Authors: Eric L. Matteson, Tim Bongartz
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Audit on the uptake of influenza and pneumococcal vaccination in patients with rheumatoid arthritis
Authors: J. Pradeep, R. Watts, G. Clunie
Journal: Annals of the Rheumatic Diseases (2007)

According to the Department of Health guidelines in the UK, patients who are immunosuppressed should be vaccinated against influenza and pneumococcal infection. 1 There are now convincing data regarding the efficacy of vaccination and use of disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA). 2-5There is evidence from other countries that the uptake of vaccination is suboptimal, especially in those aged ,65 years. 6 We undertook a study in patients attending our clinics to establish (1) vaccination uptake in our patients who are immunosuppressed, and (2) the reasons if patients had not received the influenza or pneumococcal (pneumovax) vaccination.We collected data from 155 consecutive patients attending our clinics during March 2006.We enquired about vaccination status during the winter 2005-6 using a questionnaire.We noted whether the patients had received pneumococcal vaccine previously, as this vaccine does not have to be repeated annually.We also noted the diagnosis, current DMARD and glucocorticoid use.The most common diagnosis was RA (64/155; table 1).DMARDs used were methotrexate (n = 37), sulfasalazine (n = 29), azathioprine (n = 9), prednisolone (n = 10), mycophenolate (n = 3) and tumour necrosis factor a blockade (n = 10); 57 of 155 (37%) patients were not receiving any DMARD or corticosteroids.Twenty eight (43%) patients with RA had received both influenza and pneumococcal vaccination, 24 (38%) had received neither, 12 (19%) had received influenza vaccination alone, and no patient had received pneumococcal vaccination alone.This was independent of DMARD use.Among the 105 patients with RA and/or taking DMARD, 39 (37%) had received both influenza and pneumococcal vaccine, 24 (23%) had received influenza vaccine only, 2 (2%) had received pneumococcal vaccine only, and 40 (38%) neither.
Cavernous Sinus Thrombosis Mimicked by CNS Lymphoma
Authors: Laurence G. Crocker
Journal: JAMA (1966)

GENERALIZED LYMPHOMA is a disease which presents in many ways, including central nervous system (CNS) involvement. The present case displays not only an unusual neurological manifestation of lymphoma, cranial nerve involvement, but also shows that the disease process lymphoma can be difficult to diagnose. The reviews of the subject of CNS lymphoma mention the difficulty of diagnosis, and the rarity of lymphoma presenting with neurological symptoms.<sup>1</sup>Whisnant presented a case of a 45-year-old man with a left 6th nerve palsy and other cranial nerve involvement due to a reticulum cell sarcoma in the left cerebellopontine angle and middle fossa.<sup>2</sup>Sparling reported 118 cases of malignant lymphoma, 13 of which had brain involvement.<sup>3</sup>Abbott described a syndrome caused by lymphomatous tumors arising in the eustacian tube, and involving all the cranial nerves in the middle fossa.<sup>4</sup>Hutchinson studied 229 patients with lymphoma over a 20-year period, and
More effort is needed to tackle malaria in sub-Saharan Africa, says Unicef
Authors: John Zarocostas
Journal: BMJ (2007)

Important advances have been made in recent years to reduce the malaria burden in sub-Saharan Africa through greater use of treated bed nets and better treatment, says a report by Unicef.

But despite this progress the report concludes that overall use of bed nets treated with insecticide still falls short of global targets and that a large number of children with fever are still being treated with weaker drugs and not with the more effective artemisinin based combination treatments.

More “enhanced commitments and bolder efforts” are needed, it says, by donors and governments to help meet the anti-malaria goals.

Actions needed include further strengthening of political and financial commitments and integrating malaria control into existing programmes for improving maternal and children's health, it …
Advances in Internal Medicine. Vol XII
Authors: Sanford A. Franzblau
Journal: JAMA (1965)

In this volume, apparently, the editors aimed at including something from each major subdivision of internal medicine. The sectionauthors perform creditably in presenting comprehensive reviews of their topics.  The section by Lamb, on aerospace medicine, represents a concise discussion of hypobaric and hyperbaric problems, hypoxia and hypercxia, problems of gravitational pull and its absence in orbital flights.  Of more immediate usefulness to most internists is a discussion by Mulder, of the University of Leyden, on the bacteriological examination of the sputum. With his extensive experience in acute and chronic diseases of the respiratory tract, he discusses most of the common pathogens, correlating them with histopathologic findings and giving practical information on their rapid identification. By direct smear and staining of flakes of sputum, treated in his own particular way, he facilitates the proper choice of correct antimicrobial agents early in the disease. He also includes some useful hints on diagnosis
IMPAIRED CORONARY DISTENSIBILITY, METABOLIC STATUS AND INCREASED SUBCLINICAL ATHEROSCLEROSIS
Authors: Vahid Nabavi Larijani, Fereshteh Hajsadegi, Ajay Bahandari, Michael baskett, Micheal Katz, Danielle Katz, Ferdinand Flores, Naser Ahmadi, Ramin Ebrahimi, Matthew Budoff
Journal: Journal of the American College of Cardiology (2011)
725-4 Late Survival Following Early Coronary Intervention After Fibrinolytic Therapy with Streptokinase in Acute Myocardial Infarction (Results of a randomized trial: SIAM-I)
Authors: Bernd Hammer, Cern Özbek, Armin Heisel, Wolfgang Bay, Gunther Berg, Benno Hennen, Klaus-Dieter Heib, Markus Höhn, Hauke Täger, Hermann Schieffer
Journal: Journal of the American College of Cardiology (1995)
REPORT OF A CASE OF GUNSHOT WOUND OF THE CHEST.
Authors: J. F. JENKINS
Journal: JAMA (1897)

In the evening between the hours of 8 and 9 o'clock of April 26, 1896, a messenger came to my office from Dr. O. N. Rice of Tipton, some six miles distant, requesting me to come to his assistance; that there were two persons in that hamlet who had recently received gunshot wounds. Eugene C., age 50 years, weight about 200 pounds, was shot in the chest while his assailant stood some fifteen feet from him; after shooting C., the young man fired a bullet through his own head, dying within an hour afterward. The revolver was a 32-caliber, and the bullet struck C., as the reader will observe from the photograph about two inches to the left of the right nipple passing through the lung, and although the missile has not been extracted, the present indications are that it is buried in the tissues on the anterior surface of
Cystic fibrosis carrier testing in early pregnancy by general practitioners.
Authors: H Harris, D Scotcher, N Hartley, A Wallace, D Craufurd, R Harris
Journal: BMJ (1993)

To assess the feasibility of genetic counselling in general practice by using cystic fibrosis carrier screening at the booking appointment as an integral part of routine antenatal care and as a paradigm for the wider participation of general practitioners in medical genetics.Maternal testing (male partner tested only if woman screens positive) and couple testing for cystic fibrosis carrier status in the antenatal population attending one general practice and, later, in a further six (outreach) practices also.Two partner urban training practice (pilot practice) in south Manchester, and six north west practices (two inner city, three urban, one rural dispensing).Total practice population of 50,000 (pilot practice plus six outreach practices) with an estimated 500-800 pregnancies per year.(a) Proportion of carriers of cystic fibrosis identified, counselled, and appropriately managed within the first trimester of pregnancy; (b) questionnaire and interview measures of patient satisfaction and stress.Eleven carriers of cystic fibrosis were detected including one carrier couple. This carrier couple, after extensive counselling, elected to have prenatal diagnosis by chorionic villus biopsy. The fetus was homozygous normal.General practitioners can successfully integrate genetic counselling and cystic fibrosis carrier screening into the first antenatal booking appointment. When a carrier couple is identified clinical geneticists can help with the discussion of reproductive options, and prenatal diagnosis by chorionic villus biopsy can be completed within the first trimester. The results suggest that general practitioners will have an increasingly important role in medical genetics, subject to continuing evaluation of patient acceptability and stress.
Interrelation Between Central and Peripheral Mechanisms Regulating Blood Pressure
Authors: MICHAEL F. WILSON, NEVILLE P. CLARKE, ORVILLE A. SMITH, ROBERT F. RUSHMER
Journal: Circulation Research (1961)

Electrical stimulation of selected discrete sites in the diencephalon induced a profound and coordinated response consisting of increased respiratory activity, limb movements, and cardiovascular adjustments. The effects on the cardiovascular system were similar to those of exercise, although the increases in aortic pressure, left ventricular pressure, and heart rate were greater. Massive splanchnicnerve discharge occurred immediately when the diencephalon was stimulated, but splanchilic activity abruptly fell below control levels with cessation of the stimulus. The increase in respiratory activity and the organized running movements seen during stimu lation apparently did miot contribute to the pressor and cardioaccelerator responses. There appeared to be no marked difference between control and diencephalic-stimulation experiments in the ease with which in duced pressure pulsations in the partially isolated carotid sinus caused bradycardia and blood-pressure depression. It may be that the influences of the diencephalon and carotid- sinus reflex upon blood pressures are inde pendent and sum algebraically. Experiments in which effects of epinephrine on splanchnic-nerve activity and systemic arterial pressure were measured before and during dieneephalic stimulation did not support the concept that catecholamines have an important role in normal pressor responses.
Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals
Authors: Philippe O. Szapary
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes20 June 2000Tyler's Herbs of Choice: The Therapeutic Use of PhytomedicinalsPhilippe O. Szapary, MDPhilippe O. Szapary, MDHospital of the University of Pennsylvania, Philadelphia, Pennsylvania. (Szapary)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00040 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 2nd edition. Robbers JE, Tyler VE, eds. 287 pages. Binghamton, NY: Haworth Herbal Pr; 1999. $49.95. ISBN 0789001608. Order phone 800-429-6784.Field of medicine: Complementary and alternative medicine.Format: Softcover books.Audience: Health care providers and consumers who are interested in herbal therapies.Purpose: To provide a concise evidence-based review of the most commonly used herbal preparations in the western world.Content:Tyler's Honest Herbal begins with an overview of the complicated legislative issues surrounding medicinal use of botanicals. Following are reviews of 121 herbs or dietary supplements, each 1 to 5 pages long. The book concludes with a reference summary ... Author, Article, and Disclosure InformationAffiliations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. (Szapary) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 June 2000Volume 132, Issue 12Page: 1012KeywordsClinical trialsComplementary and alternative medicineHealth information technologyHerbal medicinePharmacistsPollenProteinsSafetySoftware toolsTryptophan ePublished: 15 August 2000 Issue Published: 20 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...