tbuckley/cabot-search huggingface dataset:
LEUKEMIA-ASSOCIATED TRANSPLANTATION ANTIGENS RELATED TO MURINE LEUKEMIA VIRUS
Authors: H. Sato, E. A. Boyse, T. Aoki, C. Iritani, L. J. Old
Journal: The Journal of Experimental Medicine (1973)

Two BALB radiation leukemias are strongly rejected by hybrids of BALB with certain other mouse strains, although BALB mice themselves exhibit no detectable resistance whatever. Hybrids immunized with progressively increased inocula are resistant to 200 x 106 or more leukemia cells; their serum is cytotoxic for the leukemia cells in vitro and protects BALB mice against challenge with these BALB leukemias. The antigenic system thus identified has been named X.1. In (BALB x B6) hybrids the major determinant of resistance was shown to be a B6 gene in the K region of H-2. This is likely to be the Rgv-1 (Resistance to gross virus) locus of Lilly, which may thus be identified in this case as an Ir (Immune response) allele conferring ability to respond to X.1 antigen on MuLV and leukemia cells, and so responsible for production of X.1 antibody and the rejection of X.1+ leukemia cells by hybrid mice. Immunoelectron microscopy with X.1 antiserum (from immunized hybrids) shows labeling both on the cell surface and on virions produced by the leukemia cells. It is not known whether X.1 comprises only one or more than one antigen. Three radiation-induced BALB leukemias, one A strain radiation-induced leukemia, and 15/15 AKR primary spontaneous leukemias were typed X.1+ by the cytotoxicity test. Several other leukemias, including one induced by passage A Gross virus and one long-transplanted AKR ascites leukemia carried in (B6 x AKR)F1 hybrids, were X.1-. Normal mice of strains with a high incidence of leukemia and one other strain (129) express X.1 antigen, but evidently in amounts too small for certain detection in vitro; by the method of absorption in vivo, however, these strains could be typed X.1+ and other strains X.1-. We ascribe the X.1 antigen system tentatively to a sub-type of MuLV that is not passage A Gross virus and is probably not the dominant sub-type in strains with a high incidence of leukemia. After repeated passage in hybrids, one of the BALB leukemias became relatively resistant to rejection by the hybrid, partially lost its sensitivity to X.1 antiserum in vitro, and in electron micrographs was seen to produce fewer virions. The serum of untreated (BALB x B6) hybrids often contains cytotoxic antibody against leukemia cells, some of it probably anti-X.1. But another commonly occurring antibody, which is cytotoxic for C57BL leukemia EL4, appears to belong to another (undefined) system.
Custom-built practice premises.
Authors: I. W. Kerr
Journal: BMJ (1969)

Spontaneous Rupture of the Oesophagus SiR,-I read with interest your leading article on spontaneous rupture of the oeso- phagus (8 February, p. 334).In the final paragraph you advocate the insertion of a gastrostomy tube.This may be effective in allowing gastric suction, as you suggest, though a Ryle tube may be used instead.However, should leakage occur through the sutured tear in the oesophagus any food fed through the gastrostomy tube will only leak out into the pleural cavity and through the chest drain if that is still in situ.I have encountered a case in which this occurred, and would therefore recommend that a jejunostomy be performed instead for the purpose of feeding.My experience is in common with that of other surgeons.-I am, etc.,
STREPTOCOCCAL SEPTICAEMIA AND APLASTIC ANAEMIA: CASE REPORT
Authors: D. A. Abernethy, A. G. Gibson, A. W. Russell
Journal: BMJ (1930)

ks&R1nâ nid reslireatory mechanisms.I conlfess I finid hIis case of peculiatr scientific initerest, but amli conitelnt at pre(ent to sketch it in outline.2. Less definite in colnstituent features, but equallly st]g- gestive of periventricular dysfunietion, are cases dlistini- guislhed, itlter alia, by yawning.One imiay be takeni from a pievious comiimuniicat 1ion'2 by way of example.C. L., male, aged 25, has liad peculiar fits for about one year, rocurring oln an average at fortniiglitly intervals.They alre coil- stituted by conitiniual yawninig, withi conistanit voiding of urinle, anid are followed by violent giddiness, headachle, and occasionial vomiting.A family history of epilepsy has beeni obtaiined, but no organic signs have beeni seen on repeated examination.
Early morbidity and mortality in childhood acute lymphoblastic leukemia with very high white blood cell count
Authors: G Vaitkeviciene, M Heyman, O G Jonsson, B Lausen, A Harila-Saari, M Stenmarker, M Taskinen, T Zvirblis, A Åsberg, L Groth-Pedersen, L Rageliene, K Schmiegelow
Journal: Leukemia (2013)
Aneurysms of the Thoracic Aorta Complicating Coarctation
Authors: JESSE E. EDWARDS
Journal: Circulation (1973)

Coarctation of the aorta may become complicated by aortic aneurysms involving either the proximal or distal compartment of the vessel. Such aneurysms principally are consequences either of hypertension or of bacterial infection. The aneurysms in either compartment may be of the classical dissecting or saccular types. Saccular aneurysm may result from infection or laceration of the aorta without intramedial dissection of blood. In the ascending aorta, an additional basis for aneurysm is aortic stenosis, the latter either being congenital, or more commonly, acquired calcific in a congenital bicuspid valve.
Potentiating Endogenous Antitumor Immunity to Prostate Cancer through Combination Immunotherapy with CTLA4 Blockade and GM-CSF
Authors: Lawrence Fong, Serena S. Kwek, Shaun O'Brien, Brian Kavanagh, Douglas G. McNeel, Vivian Weinberg, Amy M. Lin, Jonathan Rosenberg, Charles J. Ryan, Brian I. Rini, Eric J. Small
Journal: Cancer Research (2009)

Abstract CTL-associated antigen 4 (CTLA4) is a costimulatory molecule expressed on activated T cells that delivers an inhibitory signal to these T cells. CTLA4 blockade with antibody treatment has been shown to augment antitumor immunity in animal models and is being developed as a treatment for cancer patients. As has been seen in preclinical models, combining CTLA4 blockade and granulocyte macrophage colony-stimulating factor (GM-CSF)–based immunotherapies can enhance the antitumor efficacy of this approach. We therefore examined whether CTLA4 blockade could be combined with GM-CSF administration. We treated 24 patients with metastatic, castration-resistant prostate cancer in a phase I trial where sequential cohorts were treated with increasing doses of ipilimumab, a fully human anti-CTLA4 antibody. Study subjects also received s.c. injections of GM-CSF at a fixed dose. Of the six patients treated at the highest dose level, three had confirmed PSA declines of &amp;gt;50%, including one patient that had a partial response in visceral metastases. Expansion of activated, circulating CD25+ CD69+ CD8+ T cells occurred more frequently at higher doses of treatment and was greater in magnitude than was seen in patients who received the same doses of either ipilimumab or GM-CSF alone. By screening sera with protein arrays, we showed that our treatment can induce antibody responses to NY-ESO-1. These results show that this combination immunotherapy can induce the expansion not only of activated effector CD8 T cells in vivo but also of T cells that are specific for known tumor-associated antigens from the endogenous immune repertoire. [Cancer Res 2009;69(2):609–15]
Nutrition Reviews' Present Knowledge in Nutrition
Authors: Wayne Callaway
Journal: JAMA (1977)

Although published as a fourth edition,<i>Nutrition Reviews' Present Knowledge in Nutrition</i>has little in common with its predecessors. It surpasses previous versions on every account. Far more comprehensive, the text has expanded fourfold since the last edition (1967), yet the individual chapters are more concisely written than in the past. Thus, more subjects are covered more thoroughly. Dramatic alterations in layout allow the volume to be read with ease and even with pleasure. In contrast with the past volumes, the present edition is attractively bound, and the type is much clearer. Illustrations are both well chosen and well presented. References, collected at the end of each chapter, no longer interrupt the flow of each sentence. In short, the new edition can be read without needless distractions. Regarding content, the volume covers most currently important aspects of human nutrition, at least briefly. Biochemical and physiological concepts are presented simply, often
New psychosocial interventions are needed in early dementia
Authors: J. Hummel, C. Weisbrod, U. Mueller-Wilmsen, P. Oster, D. Kopf
Journal: BMJ (2012)

<h3>Introduction</h3> Macrosomia refers to growth beyond a specific threshold, regardless of gestational age. These fetuses are also frequently referred to as large for gestational age (LGA). Various cut-offs have been used but for research purposes, a cut-off above the 95th centile for birth weight is often preferred because it defines 90% of the population as normal weight. The use of centiles, rather than estimated weights, also accommodates preterm macrosomic infants, although most of the complications, maternal and fetal, arise during the delivery of large babies at term. This means that accurate identification of LGA fetuses (≥95th centile) may play an important role in guiding obstetric interventions, such as induction of labour or caesarean section. Traditionally, identification of fetuses suspected of macrosomia has been based on biometric measurements using two-dimensional (2D) ultrasound (US), yet this method is rather sub-optimal. We present a protocol (V.2.1, date 19 May 2016) for the estimation of fetal weight (EFW) by MRI to PREdict neonatal MACROsomia (PREMACRO study), which is a prospective observational clinical study designed to determine whether MRI at 36 + 0 to 36 + 6 weeks of gestation, as compared with 2D US, can improve the identification of LGA neonates ≥95th centile. <h3>Methods and analysis</h3> All eligible women attending the 36-week clinic will be invited to participate in the screening study for LGA fetuses ≥95th centile and will undergo US-EFW and MRI-EFW within minutes of each other. From these estimations, a centile will be derived which will be compared with the centile of birth weight used as the gold standard. Besides birth weight, other pregnancy and neonatal outcomes will be collected and analysed. The first enrolment for the study was in May 2016. As of September 2018, 2004 women have been screened and recruited to the study. The study is due to end in April 2019. <h3>Ethics and dissemination</h3> The study will be conducted in accordance with the International Conference on Harmonisation for good clinical practice and the appropriate regulatory requirement(s). A favourable ethical opinion was obtained from the Ethics Committee of the University Hospital Brugmann, reference number CE2016/44. Results will be published in peer-reviewed journals and disseminated at international conferences. <h3>Trial registration number</h3> NCT02713568.
Challenges with advanced therapy medicinal products and how to meet them
Authors: Christian K. Schneider, Paula Salmikangas, Bernd Jilma, Bruno Flamion, Lyubina Racheva Todorova, Anna Paphitou, Ivana Haunerova, Toivo Maimets, Jean-Hugues Trouvin, Egbert Flory, Asterios Tsiftsoglou, Balázs Sarkadi, Kolbeinn Gudmundsson, Maura O'Donovan, Giovanni Migliaccio, J amacr, nis Anc amacr, Romaldas Ma ccaron, iulaitis, Jean-Louis Robert, Anthony Samuel, Johannes H. Ovelgönne, Marit Hystad, Andrzej Mariusz Fal, Beatriz Silva Lima, Anca Stela Moraru, Peter Tur ccaron, Robert Zorec, Sol Ruiz, Lennart Åkerblom, Gopalan Narayanan, Alastair Kent, Fabrizia Bignami, J. George Dickson, Dietger Niederwieser, María-Angeles Figuerola-Santos, Ilona G. Reischl, Claire Beuneu, Rosen Georgiev, Maria Vassiliou, Alena Pychova, Mette Clausen, Taina Methuen, Sophie Lucas, Martina Schüssler-Lenz, Vasilios Kokkas, Zsuzsanna Buzás, Niall MacAleenan, Maria Cristina Galli, Aija Lin emacr, Jolanta Gulbinovic, Guy Berchem, Mariusz Fr aogon, czek, Margarida Menezes-Ferreira, Nela Vilceanu, Mikuláš Hrubiško, Petra Marinko, Marcos Timón, Wing Cheng, George Andrew Crosbie, Nick Meade, Michelino Lipucci di Paola, Thierry VandenDriessche, Per Ljungman, Lucia D'Apote, Olga Oliver-Diaz, Isabel Büttel, Patrick Celis
Journal: Nature Reviews Drug Discovery (2010)
Gender Differences in the Polysomnographic Features of Obstructive Sleep Apnea
Authors: CHRIS O'CONNOR, KRISTINE S. THORNLEY, PATRICK J. HANLY
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

We examined the influence of gender on the polysomnographic features of obstructive sleep apnea (OSA) in a retrospective study of 830 patients with OSA diagnosed by overnight polysomnography (PSG). The severity of OSA was determined from the apnea– hypopnea index (AHI) for total sleep time (AHITST), and was classified as mild (5 to 25 events/h), moderate (26 to 50 events/h), and severe ( > 50/events/h). Differences in OSA during different stages of sleep were assessed by comparing the AHI during non-rapid eye movement (NREM) (AHINREM) and rapid eye movement (REM) (AHIREM) sleep and calculating the “REM difference” (AHIREM− AHINREM). Additionally, each overnight polysomnographic study was classified as showing one of three mutually exclusive types of OSA: (1) mild OSA, which occurred predominantly during REM sleep (REM OSA); (2) OSA of any severity, which occurred predominantly in the supine position (S OSA); or (3) OSA without a predominance in a single sleep stage or body position (A OSA). The mean AHITST for men was significantly higher than that for women (31.8 ± 1.0 versus 20.2 ± 1.5 events/h, p < 0.001). The male-to-female ratio was 3.2:1 for all OSA patients, and increased from 2.2:1 for patients with mild OSA to 7.9:1 for those with severe OSA. Women had a lower AHINREM than did men (14.6 ± 1.6 versus 29.6 ± 1.1 events/h, p < 0.001), but had a similar AHIREM (42.7 ± 1.6 versus 39.9 ± 1.2 events/h). Women had a significantly higher REM difference than did men (28.1 ± 1.5 versus 10.3 ± 1.1 events/h, p < 0.01). REM OSA occurred in 62% of women and 24% of men with OSA. S OSA occurred almost exclusively in men. We conclude that: (1) OSA is less severe in women because of milder OSA during NREM sleep; (2) women have a greater clustering of respiratory events during REM sleep than do men; (3) REM OSA is disproportionately more common in women than in men; and (4 ) S OSA is disproportionately more common in men than in women. These findings may reflect differences between the sexes in upper airway function during sleep in patients with OSA.
Sex and Risk of Hip Implant Failure
Authors: Maria C. S. Inacio, Christopher F. Ake, Elizabeth W. Paxton, Monti Khatod, Cunlin Wang, Thomas P. Gross, Ronald G. Kaczmarek, Danica Marinac-Dabic, Art Sedrakyan
Journal: JAMA Internal Medicine (2013)

<h3>Importance</h3>The role of sex in relationship to implant failure after total hip arthroplasty (THA) is important for patient management and device innovation.<h3>Objective</h3>To evaluate the association of sex with short-term risk of THA revision after adjusting for patient, implant, surgery, surgeon, and hospital confounders.<h3>Design and Setting</h3>A prospective cohort of patients enrolled in a total joint replacement registry from April 1, 2001, through December 31, 2010.<h3>Participants</h3>Patients undergoing primary, elective, unilateral THA.<h3>Main Outcome Measures</h3>Failure of THA, defined as revision procedure for (1) any reason, (2) septic reason, or (3) aseptic reason after the index procedure.<h3>Results</h3>A total of 35 140 THAs with 3.0 years of median follow-up were identified. Women constituted 57.5% of the study sample, and the mean (SD) patient age was 65.7 (11.6) years. A higher proportion of women received 28-mm femoral heads (28.2% vs 13.1%) and had metal on highly cross-linked polyethylene-bearing surfaces (60.6% vs 53.7%) than men. Men had a higher proportion of 36-mm or larger heads (55.4% vs 32.8%) and metal on metal-bearing surfaces (19.4% vs 9.6%). At 5-year follow-up, implant survival was 97.4% (95% CI, 97.2%-97.6%). Device survival for men (97.7%; 95% CI, 97.4%-98.0%) vs women (97.1%; 95% CI, 96.8%-97.4%) was significantly different (P = .01). After adjustments, the hazards ratios for women were 1.29 (95% CI, 1.11-1.51) for all-cause revision, 1.32 (95% CI, 1.10-1.58) for aseptic revision, and 1.17 (95% CI, 0.81-1.68) for septic revision.<h3>Conclusions</h3>After considering patient-, surgery-, surgeon-, volume-, and implant-specific risk factors, women had a 29% higher risk of implant failure than men after THA in this community-based sample.
Molecular genetic analysis of the V kappa Ser group associated with two mouse light chain genetic markers. Complementary DNA cloning and southern hybridization analysis.
Authors: M M Goldrick, R T Boyd, P D Ponath, S Y Lou, P D Gottlieb
Journal: The Journal of Experimental Medicine (1985)

Previous studies (21) have shown that two mouse kappa light (L) chain variable (V) region polymorphisms, the IB-peptide and Efla markers, reflect expression of a characteristic group of V kappa regions, called V kappa Ser, by some inbred strains and not others. Expression of V kappa Ser is controlled by a locus on chromosome 6, the chromosome that contains the kappa locus. To further characterize this V kappa group and begin to analyze the basis for its strain-specific expression, full-length complementary DNA (cDNA) copies were produced of L chain mRNA from the M75 myeloma that had been induced in the C.C58 strain of mice, and which produces a V kappa Ser L chain. The C.C58 strain is congenic with BALB/cAn, differing in the region of chromosome 6 that controls expression of the V kappa polymorphisms and the Lyt-2 and Lyt-3 T cell alloantigens. The complete nucleotide sequence of this cloned cDNA was determined and compared with the nucleotide sequences the most closely related BALB/c myeloma L chains known. Results indicated significant differences throughout the variable region, but particularly toward the 5' portion of the sequence. A probe corresponding to 200 bp of the 5' end of the cloned V kappa Ser cDNA was used in Southern hybridizations of restriction digests of liver DNA from a number of inbred, recombinant, and recombinant inbred strains. Under stringent hybridization conditions, one strongly-hybridizing fragment was observed in Bam HI, Hind III, and Eco RI digests, and based on the size of the fragments, strains could be organized into two groups. The presence of strongly hybridizing Bam HI, Hind III, and Eco RI fragments of 3.2, 2.8, and 2.1 kb, respectively, was found to correlate completely with expression by the strain of the IB-peptide and Efla markers. All nonexpressor strains yielded hybridizing fragments of 7.8, 8.4, and 2.8 kb, respectively. Possible explanations for strain-specific expression of V kappa Ser-associated phenotypic markers are discussed.
Massive overdose of adrenaline
Authors: C. S. Jones
Journal: BMJ (1967)

of these cases was strongly positive on the bone marrow, though only very weakly posi- tive on the peripheral blood.The anti-D antibody titre was 1/1,024.Exaimination of this infant's blood showed that virtually only Rh-negative cells (that is, like those given by transfusion) were present.This observation supports the hypothesis that the late anaemia seen in verysevere Rh disease is due to the persistence of antibodies in the blood.This phenomenon has become apparently more common recently, since, because intrauterine transfusion is now per- formed, these infants do not require large exchange transfusion at birth, and also there is an increasing survival of severe cases.-We are, etc.,
Health service should develop expertise in child protection, review urges
Authors: C. Dyer
Journal: BMJ (2009)

The health secretary, Alan Johnson, “must immediately address the wariness of staff throughout the health services to engage with child protection work,” a review of the current state of the system for protecting vulnerable children in England has concluded.

GPs, community nurses, and paediatricians “must be helped to develop a wider range of skills and become much more confident in this important area of their work,” urged the report, commissioned by the government from Lord Laming.

Ministers have accepted all 58 recommendations of the inquiry, which was set up after the death of baby P, a 17 month old boy who died in …
Surgical Correction of Coarctation of the Main Pulmonary Artery
Authors: WENDELL B. THROWER, WALTER H. ABELMANN, DWIGHT E. HARKEN
Journal: Circulation (1960)

Two cases of pure congenital coarctation of the main pulmonary artery are reported. One case may be unique in that it represents the first report of an anatomically proved constriction located in the middle third of the main trunk. In this patient, successful open correction under hypothermia was carried out with cinematographic documentation. The results of preoperative and postoperative cardiac catheterization are described. A plea is made for the routine use of open operation for correction of "pure pulmonic valvular stenosis." This allows better correction when the diagnosis is confirmed and flexibility for treatment if the unusual coarctation or constriction of the pulmonary artery is encountered.
Actinic damage and squamous cell carcinoma in sun-exposed skin affected by vitiligo
Authors: KA. Saarinen, G.G. Lestringant, I. Masouye, P.M. Frossard
Journal: British Journal of Dermatology (2000)

Journal Article Actinic damage and squamous cell carcinoma in sun‐exposed skin affected by vitiligo Get access KA. Saarinen, KA. Saarinen Tawam University Hospital, Department of Dermatology, PO Box 15258, Al Ain, Abu Dhabi, United Arab Emirates *University Hospital of Geneva, Department of Clinical Neurosciences and Dermatology, 24 Rue Micheli‐du‐Crest, 1211 Geneva, Switzerland †United Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pathology, United Arab EmiratesE‐mail: saarinen@emirates.net.ae Search for other works by this author on: Oxford Academic Google Scholar G.G. Lestringant, G.G. Lestringant Tawam University Hospital, Department of Dermatology, PO Box 15258, Al Ain, Abu Dhabi, United Arab Emirates *University Hospital of Geneva, Department of Clinical Neurosciences and Dermatology, 24 Rue Micheli‐du‐Crest, 1211 Geneva, Switzerland †United Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pathology, United Arab EmiratesE‐mail: saarinen@emirates.net.ae Search for other works by this author on: Oxford Academic Google Scholar I. Masouye, I. Masouye Tawam University Hospital, Department of Dermatology, PO Box 15258, Al Ain, Abu Dhabi, United Arab Emirates *University Hospital of Geneva, Department of Clinical Neurosciences and Dermatology, 24 Rue Micheli‐du‐Crest, 1211 Geneva, Switzerland †United Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pathology, United Arab EmiratesE‐mail: saarinen@emirates.net.ae Search for other works by this author on: Oxford Academic Google Scholar P.M. Frossard P.M. Frossard Tawam University Hospital, Department of Dermatology, PO Box 15258, Al Ain, Abu Dhabi, United Arab Emirates *University Hospital of Geneva, Department of Clinical Neurosciences and Dermatology, 24 Rue Micheli‐du‐Crest, 1211 Geneva, Switzerland †United Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pathology, United Arab EmiratesE‐mail: saarinen@emirates.net.ae Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 1, 1 July 2000, Pages 219–221, https://doi.org/10.1046/j.1365-2133.2000.03636.x Published: 01 July 2000