Clinical, Cytologic, and Biochemical Studies in Systemic Mast Cell Disease
Authors: J. E. ULTMANN
Journal: Annals of Internal Medicine (1964)

Case Studies1 August 1964Clinical, Cytologic, and Biochemical Studies in Systemic Mast Cell DiseaseJ. E. ULTMANN, M.D., F.A.C.P., R. D. MUTTER, M.D., M. TANNENBAUM, M.D., R. R. P. WARNER, M.D., F.A.C.P.J. E. ULTMANN, M.D., F.A.C.P.Search for more papers by this author, R. D. MUTTER, M.D.Search for more papers by this author, M. TANNENBAUM, M.D.Search for more papers by this author, R. R. P. WARNER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-326 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1869, Nettleship (1) described macular lesions of the skin that became edematous on rubbing; these were called urticaria pigmentosa by Sangster (2). Touraine, Solente, and Renault (3), in 1933, first reported a case of urticaria pigmentosa with mast cells involving organs other than the skin. Although over 600 cases of urticaria pigmentosa have been described, only 29 patients with systemic mast cell disease are on record (4). A patient diagnosed at the Francis Delafield Hospital as having systemic mast cell disease afforded us the opportunity to study this rare and interesting entity and to correlate the clinical manifestations with...References1. NETTLESHIP E: Rare forms of urticaria. Brit. Med. J. 2: 323, 1869. MedlineGoogle Scholar2. SANGSTER A: An anomalous mottled rash, accompanied by pruritus, factitious urticaria and pigmentation, "urticaria pigmentosa." Trans. Clin. Soc. Lond. 11: 161, 1878. Google Scholar3. TOURAINESOLENTERENAULT AGP: Urticaire pigmentaire avec reaction splenique et myelemique. Bull. Soc. Franc. Derm. Syph. 40: 1691, 1933. Google Scholar4. MUTTERTANNENBAUMULTMANN RDMJE: Systemic mast cell disease. Ann. Intern. Med. 59: 887, 1963. LinkGoogle Scholar5. OKANOKUNIIFURTH HAJ: An electron microscopic study of leukemia in rats induced with Gross virus. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Departments of Medicine and Pathology, College of Physicians and Surgeons, Columbia University; the Medical and Pathology Services of the Francis Delafield Hospital; and the Division of Gastroenterology, Department of Medicine of the Mount Sinai Hospital, New York, New York.This work was supported by the National Cancer Institute grant CA-02332-10 and the National Institute of Arthritis and Metabolic Diseases grant A-3228, The United States Public Health Service, Bethesda, Maryland; the Health Research Council of the City of New York (I-109); and the Anne Winton Memorial Fund.This work was presented in part at the meeting of the American Association of Cancer Research, Toronto, Canada, May 23, 1963.Requests for reprints should be addressed to John E. Ultmann, M.D., Institute of Cancer Research, Columbia University, 630 West 168th Street, New York City 10032. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmunosenescence, Inflammaging, and Their Implications for Cancer and AnemiaA new role for mast cells as scavengers for clearance of erythrocytes damaged due to oxidative stressBone marrow findings in adult patients with urticaria pigmentosaMast cell disease followed by leukemia with clonal evolutionOligoclonal Immunoglobulins in MastocytosisWILLIAM J. MEGGS, M.D., Ph.D., MARIANNE FRIERI, M.D., Ph.D., RENE COSTELLO, B.S., DEAN D. METCALFE, M.D., NICHOLAS M. PAPADOPOULOS, Ph.D.The Spectrum of MastocytosisCytobiological and Clinical Aspects of Tissue Mast Cell LeukaemiaMast cells and mast cell neoplasia: a reviewGastrointestinal involvement in systemic mastocytosis.Histidine decarboxylase in gastric tissues of primatesMastzellenretikulose (Mastocytose) 1 August 1964Volume 61, Issue 2Page: 326-333KeywordsHospital medicineLesionsMast cellsMastocytosisMedical servicesMetabolic disordersNauseaSurgeonsSystemic mastocytosisUrticaria Issue Published: 1 August 1964 PDF DownloadLoading ...