Panlobular and Centrilobular Emphysema
Authors: HERBERT C. SWEET
Journal: Annals of Internal Medicine (1961)

Article1 October 1961Panlobular and Centrilobular EmphysemaCorrelation of Clinical Findings with Pathologic PatternsHERBERT C. SWEET, M.D., F.A.C.P., JOHN P. WYATT, M.D., ANDREW J. FRITSCH, M.D., PETER W. KINSELLA, M.D.HERBERT C. SWEET, M.D., F.A.C.P.Search for more papers by this author, JOHN P. WYATT, M.D.Search for more papers by this author, ANDREW J. FRITSCH, M.D.Search for more papers by this author, PETER W. KINSELLA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-565 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDistinctive anatomical patterns have been described for pulmonary emphysema in recent years, due principally to the increased use of the macrosection technique. These have been grouped into centrilobular (1, 2), and panlobular (3) [panacinar] (4) types, and a group combining the characteristics of the two.The anatomic differences between centrilobular and panlobular emphysema depend upon the recognition of the secondary lobule of Miller (5). The respiratory bronchioles, accompanied by arterioles, are situated in the central portion of the secondary lobule; the pulmonary venules are found in the connective tissue of the periphery.The earliest centrilobular lesion consists of ectasia, then...References1. LEOPOLDGOUGH JJ: The centrilobular form of hypertrophic emphysema and its relation to chronic bronchitis. Thorax 14: 113, 1957. Google Scholar2. WYATTSWEETFISCHER JHV: Centrilobular emphysema. Lab. Invest. 10: 159, 1961. MedlineGoogle Scholar3. WYATT J: Macrosection and injection studies of emphysema. Amer. Rev. Resp. Dis. 80: 94, 1959. MedlineGoogle Scholar4. A report of conclusions of CIBA guest symposium: terminology, definition, and classification of chronic pulmonary emphysema and related conditions. Thorax 14: 286, 1959. CrossrefGoogle Scholar5. MILLER W: The Lung, 2nd Ed., Charles C Thomas, Springfield, Ill., 1947. Google Scholar6. SWEETWYATTKINSELLA HJP: Correlation of lung macrosection with pulmonary function in emphysema. Amer. J. Med. 19: 277, 1960. CrossrefGoogle Scholar7. BALDWINCOURNANDRICHARDS EAD: Pulmonary insufficiency. I. Physiological classification, clinical methods of analysis, standard values in normal subjects. Medicine 27: 243, 1948. CrossrefMedlineGoogle Scholar8. SIMPSON T: Chronic bronchitis and emphysema. Tubercle 39: 307, 1958. CrossrefMedlineGoogle Scholar9. BALDWINCOURNANDRICHARDS EAD: Pulmonary insufficiency. III. A study of 122 cases of chronic pulmonary emphysema. Medicine 28: 201, 1949. CrossrefMedlineGoogle Scholar10. OGILVIE C: Patterns of disturbed lung function in patients with chronic obstructive vesicular emphysema. Thorax 14: 113, 1959. CrossrefMedlineGoogle Scholar11. RICHARDS D: Pulmonary emphysema: etiologic and clinical forms. Ann. Intern. Med. 53: 1105, 1960. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HERBERT C. SWEET, M.D., F.A.C.P.; JOHN P. WYATT, M.D.; ANDREW J. FRITSCH, M.D.; PETER W. KINSELLA, M.D.Affiliations: St. Louis, MissouriReceived for publication June 6, 1961.From the James B. and Ethel D. Miller Pulmonary Laboratory, Department of Internal Medicine, and the Department of Pathology, St. Louis University School of Medicine, St. Louis, Mo.Supported in part by U. S. Public Health Service Grant H-3737.Requests for reprints should be addressed to Herbert C. Sweet, M.D., Pulmonary Laboratory, Firmin Desloge Hospital of St. Louis University1325 South Grand Boulevard, St. Louis 4, Mo. 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AZCUY, M.D., A. E. ANDERSON JR., M.D., ALVAN G. FORAKER, M.D. 1 October 1961Volume 55, Issue 4Page: 565-581KeywordsAnatomical pathologyDyspneaEmphysemaLesionsMedical servicesPathology and laboratory medicinePneumoniaResearch laboratoriesVentilatorsVenules ePublished: 1 December 2008 Issue Published: 1 October 1961 PDF downloadLoading ...