tbuckley/cabot-search huggingface dataset:
New Treatments for Psoriasis
Authors: Richard D. Granstein
Journal: New England Journal of Medicine (2001)

Psoriasis is an inflammatory skin disorder that affects about 1 to 3 percent of persons throughout the world.1 Although most persons with plaque psoriasis have mild or moderate disease that affects small areas of the skin, some have extensive disease that is severe and difficult to treat. It is not known why some persons have severe disease and others have mild involvement.One theory of the pathogenesis of psoriasis is that it is primarily a disorder that involves the proliferation of keratinocytes, with secondary inflammation. Supporters of this concept have noted defects in cytokine expression, intracellular signaling, and polyamines, as . . .
Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity
Authors: Sinforiano J. Posadas, Antonia Padial, Maria J. Torres, Cristobalina Mayorga, Laura Leyva, Elena Sanchez, Javier Alvarez, Antonino Romano, Carlos Juarez, Miguel Blanca
Journal: Journal of Allergy and Clinical Immunology (2002)
Abstract 1385: Real-time imaging of paxillin-GFP expression in breast cancer cells in vitro and in vivo
Authors: Atsushi Suetsugu, Michelle Digman, Enrico Gratton, Hisataka Moriwaki, Shigetoyo Saji, Michael Bouvet, Robert M. Hoffman
Journal: Cancer Research (2011)

Abstract Paxillin is involved in the assembly of focal adhesions. In this study, we describe real-time imaging of paxillin-GFP expression in breast cancer cells (MDA-MB-231) in vitro and in vivo. In vitro, round cancer cells had greater paxilin movement than stretched cancer cells as seen by fluorescence imaging. When paxillin-GFP breast cancer cell (1×106) were injected in the epigastric cranials vein, round cancer cells had GFP-expressing protrusions. Many paxillin-GFP-expressing breast cancer cells stretched. The cancer cells extravasated and subsequently grew around the outer surface of the blood vessel after one week. Migration of single cells in vivo was observed by fluorescence microscopy. Two weeks after cell injection, paxillin-GFP breast cancer cells migrated along the vessel wall. Most of paxillin-GFP cancer cells were stretched and were not mobile. With anti-VEGF treatment, paxillin was observed in round structures rather than stretched structures and paxillin movement within the cell were arrested. The results show that paxillin-GFP allows the imaging of the role of paxillin in vitro and in vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1385. doi:10.1158/1538-7445.AM2011-1385
Operating to remove recurrent colorectal cancer: have we got it right?
Authors: Tom Treasure, Kathryn Monson, Francesca Fiorentino, Christopher Russell
Journal: BMJ (2014)

A randomised controlled trial that remained unpublished for 20 years casts doubt on the survival benefit of further surgery after curative resection of colorectal cancer. <b>Tom Treasure and colleagues</b> tell the story of the first trial restored under the restoring invisible and abandoned trials initiative and discuss what it means today
Benefits of effective hospital services for elderly people.
Authors: J Mitchell, K Kafetz, B Rossiter
Journal: BMJ (1987)

An age related hospital service for elderly people was set up in Waltham Forest Health Authority to provide acute medical care when needed. Despite a reduction in the allocation of funds over the years 1982-4 the health authority increased the number of district general hospital beds available for elderly patients and improved home nursing services. The outcomes of the changes made were assessed against the aims of the service by using data from the Hospital Activity Analysis, SH3 returns, government population estimates, and yearly figures collected in our department. It is concluded that introducing an age related service in our health authority has benefited people aged over 65.
Blood and Bone: Poems by Physicians
Authors: Phillip J. Cozzi
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes17 August 1999Blood and Bone: Poems by PhysiciansPhillip J. Cozzi, MDPhillip J. Cozzi, MDElmhurst Memorial Hospital, Elmhurst, Illinois. (Cozzi)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-4-199908170-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Belli A, Coulehan J; eds. 224 pages. Iowa City, IA: Univ of Iowa Pr; 1998. $17.95. ISBN 0877456380. Order phone 773-568-1550.Field of medicine: Medical humanities.Format: Softcover book.Audience: All practitioners of medicine.Purpose: To anthologize the work of the foremost contemporary physician-poets.Content: One hundred poems by 31 authors are presented in four thematic sections. The first section portrays patients, physicians, and the unique relationships between the two. The second section focuses on the contrast between physicians' professional and private lives. The third section celebrates the learning experience, often in the most unlikely forms. The final grouping of ... Author, Article, and Disclosure InformationAffiliations: Elmhurst Memorial Hospital, Elmhurst, Illinois. (Cozzi) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 August 1999Volume 131, Issue 4Page: 315-316KeywordsBloodBoneComputer softwareMedical ethics, humanities, and education Issue Published: 17 August 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Prognostic impact of sleep‐disordered breathing and its treatment with nocturnal ventilation for chronic heart failure
Authors: Thibaud Damy, Laurent Margarit, Ala Noroc, Diane Bodez, Soulef Guendouz, Laurent Boyer, Xavier Drouot, Aurélia Lamine, Alexandra Paulino, Stéphane Rappeneau, Maria‐Hermann Stoica, Jean‐Luc Dubois‐Randé, Serge Adnot, Luc Hittinger, Marie Pia d'Ortho
Journal: European Journal of Heart Failure (2012)
Once-Daily Fluticasone Furoate Nasal Spray (FFNS) Significantly Improves Nasal Congestion in Subjects with Seasonal Allergic Rhinitis (SAR)
Authors: M. Vandewalker, R. Jacobs, C. Andrews, S. Yun Kirby, A. Ellsworth, E.E. Philpot
Journal: Journal of Allergy and Clinical Immunology (2009)
From evidence to action to deliver a healthy start for the next generation
Authors: Elizabeth Mason, Lori McDougall, Joy E Lawn, Anuradha Gupta, Mariam Claeson, Yogan Pillay, Carole Presern, Martina Baye Lukong, Gillian Mann, Marijke Wijnroks, Kishwar Azad, Katherine Taylor, Allison Beattie, Zulfiqar A Bhutta, Mickey Chopra
Journal: The Lancet (2014)
Lung Tissue Resistance in Diffuse Interstitial Pulmonary Fibrosis*
Authors: H. Bachofen, M. Scherrer
Journal: Journal of Clinical Investigation (1967)

1) Measured during spontaneous breathing in ten patients with diffuse interstitial lung disease, total pulmonary resistance averaged 3.53 ± 1.56 cm H2O per L per second; airway resistance, 1.63 ± 0.79 cm H2O per L per second; and lung tissue resistance, 1.90 ± 0.95 cm H2O per L per second (range, 0.89 to 3.96). The lung tissue resistance was on an average about four times higher in patients with lung fibrosis than in ten healthy persons of the same age. No significant difference in airway resistance was found between healthy subjects and patients.
TCT-733 Relation of Proton pump inhibitor and cytochrome P450 2C19 polymorphisms on pletelet reactivity in patients with acute coronary syndromes
Authors: Zenko Nagashima, Toshiaki Ebina, Mitsuaki Endo, Kiyoshi Hibi, Kazuo Kimura, Nobuhiko Maejima, Zenko Nagashima, Kozo Okada, Kengo Tsukahara, Satoshi Umemura
Journal: Journal of the American College of Cardiology (2012)
FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma
Authors: Tokuzo Arao, Kazuomi Ueshima, Kazuko Matsumoto, Tomoyuki Nagai, Hideharu Kimura, Satoru Hagiwara, Toshiharu Sakurai, Seiji Haji, Akishige Kanazawa, Hisashi Hidaka, Yukihiro Iso, Keiichi Kubota, Mitsuo Shimada, Tohru Utsunomiya, Masashi Hirooka, Yoichi Hiasa, Yoshikazu Toyoki, Kenichi Hakamada, Kohichiroh Yasui, Takashi Kumada, Hidenori Toyoda, Shuichi Sato, Hiroyuki Hisai, Teiji Kuzuya, Kaoru Tsuchiya, Namiki Izumi, Shigeki Arii, Kazuto Nishio, Masatoshi Kudo
Journal: Hepatology (2012)

The response rate to sorafenib in hepatocellular carcinoma (HCC) is relatively low (0.7%-3%), however, rapid and drastic tumor regression is occasionally observed. The molecular backgrounds and clinico-pathological features of these responders remain largely unclear. We analyzed the clinical and molecular backgrounds of 13 responders to sorafenib with significant tumor shrinkage in a retrospective study. A comparative genomic hybridization analysis using one frozen HCC sample from a responder demonstrated that the 11q13 region, a rare amplicon in HCC including the loci for FGF3 and FGF4, was highly amplified. A real-time polymerase chain reaction-based copy number assay revealed that FGF3/FGF4 amplification was observed in three of the 10 HCC samples from responders in which DNA was evaluable, whereas amplification was not observed in 38 patients with stable or progressive disease (P = 0.006). Fluorescence in situ hybridization analysis confirmed FGF3 amplification. In addition, the clinico-pathological features showed that multiple lung metastases (5/13, P = 0.006) and a poorly differentiated histological type (5/13, P = 0.13) were frequently observed in responders. A growth inhibitory assay showed that only one FGF3/FGF4-amplified and three FGFR2-amplified cancer cell lines exhibited hypersensitivity to sorafenib in vitro. Finally, an in vivo study revealed that treatment with a low dose of sorafenib was partially effective for stably and exogenously expressed FGF4 tumors, while being less effective in tumors expressing EGFP or FGF3.FGF3/FGF4 amplification was observed in around 2% of HCCs. Although the sample size was relatively small, FGF3/FGF4 amplification, a poorly differentiated histological type, and multiple lung metastases were frequently observed in responders to sorafenib. Our findings may provide a novel insight into the molecular background of HCC and sorafenib responders, warranting further prospective biomarker studies.
Mutations in phospholipase C epsilon 1 are not sufficient to cause diffuse mesangial sclerosis
Authors: Rodney D. Gilbert, Claire L.S. Turner, Jane Gibson, Paul S. Bass, Mushfequr R. Haq, Esta Cross, David J. Bunyan, Andrew R. Collins, William J. Tapper, Juliet C. Needell, Beverley Dell, Newton E. Morton, I. Karen Temple, David O. Robinson
Journal: Kidney International (2008)
A 63-year-old male with marked eosinophilia and dyspnoea on exertion
Authors: S-H Kim, Y Nawa, H Y Kim, W Kwon, S J Yong, S H Jung
Journal: Thorax (2009)

A 63-year-old male farmer presented marked eosinophilia. He had no symptoms of fever, night sweats or weight loss and no signs of anaemia, jaundice or lymphadenopathy. The leucocyte count was 17.27×109/l, with 53.1% eosinophils, but no eggs or parasites were found in his faeces. Blood chemistry results were within normal limits except for an elevated alanine aminotransferase level of 77 U/l. Serum total …
Histocompatibility antigens: Markers of susceptibility to and protection from alcoholic liver disease in a portuguese population
Authors: Estela Monteiro, Patricia M. Alves, Livia M. Santos, Isabel Quintas, Amelia Baptista, Alberto Galvao-Teles, Judith S. Gavaler
Journal: Hepatology (1988)

The distribution of six HLA antigens in a population of 88 Portuguese chronic alcohol abusers with biopsy-proven liver disease was compared to that in 66 Portuguese normal controls. Among the group of 88 alcohol abusers, the presence of HLA antigens A1, A9, A28 and Bw35 marked a significant 2.5- to 3-fold increased estimated risk for the development of alcohol-induced cirrhosis, while the presence of HLA B5 was found to be associated with a significantly decreased risk of alcohol-induced cirrhosis. Further, compared to controls, the estimated risk of any stage of alcohol-induced liver disease was significantly increased in alcoholic individuals with HLA A28 and Bw35, and the protective effect of HLA B5 was again observed. The findings of this study suggest that at least in a relatively homogeneous population group such as the Portuguese, the presence of HLA B5 may confer protection against alcohol-induced liver disease, including cirrhosis. The presence of HLA Bw35 and A28 appear to mark susceptibility to all histologic manifestations of alcohol-induced liver disease, while in addition to Bw35 and A28, A1 and A9 may mark increased risk for cirrhosis in particular.
Metabolic model for cadmium in man.
Authors: G F Nordberg, T Kjellström
Journal: Environmental Health Perspectives (1979)

A metabolic model for cadmium has been formulated in terms of a flow scheme for cadmium among eight body compartments. The mathematical description of the flow of cadmium between compartments consits of a number of differential equations, and the accumulation of cadmium may thus be calculated. Coeffcients for the flow of cadmium were estimated from empirical data both from animals and man. The modelling serves two main purposes: it provides a means of using present knowledge about metabolism in order to calculate expected accumulation in critical organs and other tissues and body fluids at certain intake levels and it makes it possible to define deficiencies in our present knowledge about metabolism. Data recently collected, partly as a result of considerations related to the model, have confirmed the assumptions of a very long biological half-time in other tissues and the small excretion of cadmium via bile.
Fever and immunoregulation. III. Hyperthermia augments the primary in vitro humoral immune response.
Authors: H D Jampel, G W Duff, R K Gershon, E Atkins, S K Durum
Journal: The Journal of Experimental Medicine (1983)

We have examined the possibility that hyperthermia, such as that occurring during fever, may benefit the immune response. The effect of temperature on the in vitro immune response of unprimed murine spleen cells against the antigen sheep erythrocytes was tested. Hyperthermia potently augmented the plaque-forming cell response. Temperature-sensitive events occurred early in the culture period. Subsets of lymphocytes were independently assessed for effects of temperature on their activation and function. We showed that the beneficial effect of elevated temperature on the plaque-forming cell response probably occurs during the priming stage of T helper cells, and neither improves the delivery of help or the activation of B cells, nor impairs suppressor T cell generation or function. We propose that this powerful immunopotentiating effect of hyperthermia may account for the selective value of the fever response. This suggests taht the monokine interleukin 1, which is the endogenous mediator of fever, may promote immune responses both through a direct action on lymphocytes, and indirectly by an action on the central nervous system resulting in fever.
Reviews and Notes: Where There Is No Doctor. A Village Health Care Handbook
Authors: William A. Reynolds
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 December 1996Reviews and Notes: Where There Is No Doctor. A Village Health Care HandbookWilliam A. Reynolds, MDWilliam A. Reynolds, MDWestern Montana Clinic, Missoula, MT 59807.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-12-199612150-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 2nd edition. D Werner, with C Thurman and J Maxwell. 481 pages. Palo Alto, CA: Hesperian Foundation; 1992. $17.00. ISBN 0-942364-15-5. Order phone 415-325-9017.Home health care manuals are a dime a dozen, but this one is in a league by itself. Readers may be surprised to find a review in Annals of a handbook designed primarily for nonphysicians in the Third World, but this book will have great appeal for anyone who is interested or involved in improving health and medical care in the rural areas of Third World nations. The authors have presented information clearly and in simple ... Author, Article, and Disclosure InformationAffiliations: Western Montana Clinic, Missoula, MT 59807. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1996Volume 125, Issue 12Page: 1023KeywordsAIDSDrugsHealth careHypertensionNursesNutritionPrevention, policy, and public healthRural areasSanitationThermometers ePublished: 15 August 2000 Issue Published: 15 December 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas
Authors: Martin H. Ruttledge, Julie Sarrazin, Shyam Rangaratnam, Catherine M. Phelan, Elspeth Twist, Philippe Merel, Olivier Delattre, Gilles Thomas, Magnus Nordenskjöld, V. Peter Collins, Jan P. Dumanski, Guy A. Rouleau
Journal: Nature Genetics (1994)
Common-Sense Models of Health and Disease
Authors: Muriel R. Gillick
Journal: New England Journal of Medicine (1985)

The "biomedical model," which serves as the foundation of contemporary, Western, scientific medicine, has at its core biologic theory, which seeks to explain the causes, pathophysiology, and course of illness.1 It is the logic of this theory that dictates the physician's approach to the diagnosis and treatment of disease.Many middle-class, educated Americans think about illness — its cause and its cure — in ways that are alien to those of their physicians. The views of patients constitute an interconnected set of ideas or principles that help them make sense of disease. These popular models differ from the biomedical model . . .
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses
Authors: Melissa L. Precopio, Michael R. Betts, Janie Parrino, David A. Price, Emma Gostick, David R. Ambrozak, Tedi E. Asher, Daniel C. Douek, Alexandre Harari, Giuseppe Pantaleo, Robert Bailer, Barney S. Graham, Mario Roederer, Richard A. Koup
Journal: The Journal of Experimental Medicine (2007)

Vaccinia virus immunization provides lifelong protection against smallpox, but the mechanisms of this exquisite protection are unknown. We used polychromatic flow cytometry to characterize the functional and phenotypic profile of CD8+ T cells induced by vaccinia virus immunization in a comparative vaccine trial of modified vaccinia virus Ankara (MVA) versus Dryvax immunization in which protection was assessed against subsequent Dryvax challenge. Vaccinia virus–specific CD8+ T cells induced by both MVA and Dryvax were highly polyfunctional; they degranulated and produced interferon γ, interleukin 2, macrophage inflammatory protein 1β, and tumor necrosis factor α after antigenic stimulation. Responding CD8+ T cells exhibited an unusual phenotype (CD45RO−CD27intermediate). The unique phenotype and high degree of polyfunctionality induced by vaccinia virus also extended to inserted HIV gene products of recombinant NYVAC. This quality of the CD8+ T cell response may be at least partially responsible for the profound efficacy of these vaccines in protection against smallpox and serves as a benchmark against which other vaccines can be evaluated.
The biological exposure indices: a key component in protecting workers from toxic chemicals.
Authors: M S Morgan
Journal: Environmental Health Perspectives (1997)

Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exposure. Judgments regarding the acceptable level of a chemical or its metabolite in biological samples are facilitated by comparison to a reference value. The American Conference of Governmental Industrial Hygienists has established a series of recommended reference values called the Biological Exposure Indices (BEI). The history and characteristics of the BEI are reviewed, and their suitability for use by occupational health specialists is examined. A number of challenges and stimuli to the continued development and improvement of these reference values are described, and the impact of recent advances in macromolecular biology is assessed.
Melanoma-Reactive T Cells in the Bone Marrow of Melanoma Patients: Association with Disease Stage and Disease Duration
Authors: Jan Müller-Berghaus, Katrin Ehlert, Selma Ugurel, Viktor Umansky, Mariana Bucur, Volker Schirrmacher, Philipp Beckhove, Dirk Schadendorf
Journal: Cancer Research (2006)

Using IFN-gamma enzyme-linked immunospot, we investigated reactivity of T cells from bone marrow and peripheral blood to melanoma lysate-pulsed autologous dendritic cells in 40 melanoma patients. Melanoma-reactive T cells were present in the bone marrow of seven patients and in peripheral blood of four patients. In the bone marrow, melanoma-reactive T cells were present in 6 of 21 stage IV patients and in 1 of 10 stage III patients, whereas none were detected in stage I to II patients (0 of 9). The occurrence of tumor-reactive bone marrow T cells in melanoma patients was associated with advanced disease stage, disease duration and tumor load, and independent of treatment. These findings provide new insights into the generation of T-cell responses in melanoma patients.
Controlled trial of enalapril in patients with chronic fluid overload undergoing dialysis
Authors: B Oldenburg, G J MacDonald, S Shelley
Journal: BMJ (1988)

<h3></h3> <b>Background:</b> Anti-glutamic acid decarboxylase 65 (anti-GAD65) antibody encephalitis is a rare form of autoimmune encephalitis that can lead to severe neurologic impairment, coma, and death. <b>Case Report:</b> We present the case of a 54-year-old male with severely altered mental status and profound neurologic impairment who rapidly progressed to a comatose state. Because of the patient9s rapidly deteriorating status, lack of yield with diagnostic testing, and lack of clinical improvement with broad empiric treatments, the clinical decision was made to treat the patient with high-dose methylprednisolone, and the treatment returned the patient to his baseline mental status. After the patient9s discharge, the autoimmune encephalitis panel returned positive for anti-GAD65 antibodies. <b>Conclusion:</b> This case illustrates the importance of considering a diagnosis of autoimmune encephalitis for patients with rapidly deteriorating mental status. Unless contraindicated, treatment with high-dose glucocorticoids can be successful for these patients. This case also shows a potential association between hypothyroidism and anti-GAD65 antibodies.