tbuckley/cabot-search huggingface dataset:
Recent Portal or Mesenteric Venous Thrombosis: Increased Recognition and Frequent Recanalization on Anticoagulant Therapy
Authors: Bertrand Condat, Fabienne Pessione, Marie Helene Denninger, Sophie Hillaire, Dominique Valla
Journal: Hepatology (2000)

Characteristics and outcomes of recent portal or mesenteric venous thrombosis are ill-known. We intended to compare these features with those of patients with portal cavernoma, and also to assess the incidence of recanalization of recent thrombosis on anticoagulation therapy. All patients seen between 1983 and 1999 were enrolled into this retrospective study if recent portal or mesenteric venous thrombosis or portal cavernoma had been documented, and if cancer of the liver, pancreas, or bile duct, intrahepatic block including cirrhosis, and obstruction of the hepatic veins had been ruled out. The proportion of recent thrombosis was 7% in patients seen before 1990 and 56% after 1994 ( P &lt; .05). Patients with recent thrombosis (n = 33) or cavernoma (n = 108) did not differ with regard to age, sex ratio, or prevalence of prothrombotic states and of previous thrombotic events. In patients with recent thrombosis, septic pylephlebitis was more common and the incidence of gastrointestinal bleeding was lower (2.4 vs. 12.7/100 patient-years). Recanalization occurred in 25 of 27 patients given anticoagulation and 0 of 2 patients not given anticoagulation. The probability of recanalization was related to the extent of thrombosis ( P = .003). In conclusion, mesenteric or portal venous thrombosis is increasingly recognized at an early stage. The features differentiating recent thrombosis and cavernoma are related to silent onset precluding early recognition and therapy in the latter. Frequent association with prothrombotic states and frequent recanalization on anticoagulation support the recommendation of early anticoagulation therapy in all patients with recent portal vein thrombosis.
Safety Reporting in Clinical Trials
Authors: Katrin S. Kohl
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Specific T helper cells that activate B cells polyclonally. In vitro enrichment and cooperative function.
Authors: A A Augustin, A Coutinho
Journal: The Journal of Experimental Medicine (1980)

C3H/HeJ T cells which specifically recognize B cell-surface antigens of the related, major histocompatibility complex-compatible C3H/Tif strain, can be substantially enriched in vitro by long-term exposure (2--6 wk) of primed lymph node cells to the relevant cellular antigens. These enriched T cells contain functional helper cells as demonstrated by their capacity to induce large numbers of Ig-secreting plaque-forming cells (PFC) in cultures of antigenic B cells. The cooperative interaction results in activation of a large fraction of all splenic B cells, with consequent exponential growth and maturation to high rate secretion of IgM, IgG1, and IgG2, but not IgG3. The IgM PFC response includes antibody specificities to a number of different antigens and can be considered, therefore, as polyclonal. The T helper cell-dependent B-cell response is insensitive to inhibition by anti-delta antibodies, and in contrast with lipopolysaccharide-induced PFC responses, is only partially sensitive to the inhibitory effects of anti-mu antibodies. Finally, B-cell activation to growth and maturation by helper T cells strictly required direct T-cell recognition of antigens on the surface of responding B cells, leading us to the conclusions that if any soluble factors are generated in the collaborative process, they are either antigen specific or incompetent to initiate B-cell growth.
Mechanisms In Symptom Formation
Authors: Herbert Weiner
Journal: JAMA (1975)

The 28 papers delivered at this congress deal with a variety of topics that range far beyond those that the title of this volume suggests: Wittkower and Warnes (Montreal) write about the incidence and prevalence of various diseases in different societies. Hamburg (Stanford) reviews the ways patients adapt to life-threatening injury and illness. The volume contains three excellent papers on the organization and implementation of liaison psychiatric services. Several papers deal with sociocultural factors in illness, specifically the effects of social change in New Guinea, Switzerland, and Japan on the incidence and prevalence of symptoms and illness. Two sections of the conference were devoted to psychological factors in the predisposition to migraine and myocardial infarction and in their initiation, and hypochondriacal symptoms and the relationship of anxiety and depression to illness. There are two interesting papers on biogenic amines in synaptic transmission. Perhaps the most innovative sections deal with two
The Effect of Delipidated Deglycolipidated (DDMV) and Heat-killed <i>Mycobacterium vaccae</i> in Asthma
Authors: PHILIPPA M. SHIRTCLIFFE, STEPHANIE E. EASTHOPE, SOO CHENG, MARK WEATHERALL, PAUL L. J. TAN, GRAHAM LE GROS, RICHARD BEASLEY
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Experimental and epidemiological evidence supports the hypothesis that exposure to mycobacteria has the potential to suppress the development of asthma and/or atopy and there are reports in the Chinese medical literature of repeated vaccination with inactivated BCG being effective in the management of asthma. Forty-three patients with stable moderately severe asthma who were skin prick test positive to house dust mite were randomized to receive two intradermal injections of either phosphate-buffered saline (placebo), heat-killed Mycobacterium vaccae (0.5 mg), or delipidated deglycolipidated Mycobacterium vaccae (DDMV) (0.05 mg). Markers of asthma severity were measured for 3 mo and blood eosinophil, IgE levels, and the T cell proliferative and cytokine responses were monitored. There were no significant differences between either treatment group and the placebo group for any of the outcome variables. There was also no difference between the treatment groups and placebo for eosinophil, IgE levels, or the T cell proliferative and cytokine response. The results indicate no effect of low dose intradermal DDMV or M. vaccae on asthma severity in patients with established asthma.
THE INFLUENCE OF THE POSITION OF THE PATIENT IN LABOR IN CAUSING UTERINE INERTIA AND PELVIC DISTURBANCES.Read before the Gynecological Society of Boston, December 11, 1890.
Authors: AUGUSTUS P. CLARKE
Journal: JAMA (1891)

It has been generally taught that during the first stage of labor the patient may be allowed to assume that position which she considers the easiest for herself. Some accoucheurs encourage the patient not to take to the bed at the beginning of labor, but for the influence of the pressure of her own hands and the weight of the fætus in aiding flexion of the head and in promoting dilatation of the cervix, to maintain the sitting or upright posture. In the early stage, the dorsal position is often assumed; later, for convenience in making frequent inspection of the perineum, in assisting to carry out certain manipulative procedures, and in giving the necessary attention to uterine and rectal discharges, the left lateral posture is often advised. Some place the patient on the side to which the occipital presentation is inclined. Some reverse the position by placing the patient on
Bilateral Symmetrical Ollier Disease and Tc-99m MDP Bone Scintigraphy
Authors: Halil Kaya, Halil Komek, Sevim Sureyya Cerci, Sadiye Altun Tuzcu
Journal: Clinical Nuclear Medicine (2004)

Enchondromas are benign cartilaginous neoplasms of bone. Ollier disease is a nonhereditary disorder characterized by multiple enchondromas with a predilection for unilateral distribution. Ollier disease is usually detected in children younger than 10 years of age. Enchondromas tend to occupy the diaphyseal region in the short tubular bones and the metaphyseal region in the long bones. Notable clinical problems are progressive shortening of the involved extremity, angular deformity, pathologic fractures, and malignant transformation. Radionuclide bone scanning is one method used to assess lesions depicted on radiographs or MR images that are presumed to be enchondromas
The Canadian C-Spine Rule, used by nurses, accurately identified cervical-spine injury in patients with trauma
Authors: William J. Meurer
Journal: Annals of Internal Medicine (2011)

Source Citation Stiell IG, Clement CM, O’Connor A, et al. Multicentre prospective validation of use of the Canadian C-Spine Rule by triage nurses in the emergency department. CMAJ. 2010;182:1173-9. 20457772
Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine
Authors: Mohamed S. Pendekal, Pramod K. Tegginamat
Journal: Acta Pharmaceutica Sinica B (2012)

Tizanidine hydrochloride (THCl) is an antispasmodic agent which undergoes extensive first pass metabolism making it a possible candidate for buccal delivery. The aim of this study was to prepare a monolayered buccal patch containing THCl using the emulsification solvent evaporation method. Fourteen formulations were prepared using the polymers Eudragit® RS 100 or Eudragit® RL 100 and chitosan. Polymer solutions in acetone were combined with a THCl aqueous solution (in some cases containing chitosan) by homogenization at 9000 rpm for 2 min in the presence of triethyl citrate as plasticizer and cast in novel Teflon molds. Physicochemical properties such as film thickness, in vitro drug release and in vitro mucoadhesion were evaluated after which permeation across sheep buccal mucosa was examined in terms of flux and lag time. Formulations prepared using a Eudragit® polymer alone exhibited satisfactory physicomechanical properties but lacked a gradual in vitro drug release pattern. Incorporation of chitosan into formulations resulted in the formation of a porous structure which did exhibit gradual release of drug. In conclusion, THCl can be delivered by a buccal patch formulated as a blend of Eudragit® and chitosan, the latter being necessary to achieve gradual drug release.
Ancestry–Environment Interactions and Asthma Risk among Puerto Ricans
Authors: Shweta Choudhry, Esteban González Burchard, Luisa N. Borrell, Hua Tang, Ivan Gomez, Mariam Naqvi, Sylvette Nazario, Alphonso Torres, Jesus Casal, Juan Carlos Martinez-Cruzado, Elad Ziv, Pedro C. Avila, William Rodriguez-Cintron, Neil J. Risch
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

Puerto Ricans, an admixed population of African, European, and Native American ancestries, have the highest asthma prevalence, morbidity, and mortality rates of any United States' population. Although socioeconomic status (SES) is negatively correlated with asthma incidence in most populations, no such relationship has been identified among Puerto Ricans. We hypothesized that, in this admixed population, the association between SES and asthma may interact with genetic ancestry.We analyzed 135 Puerto Rican subjects with asthma and 156 control subjects recruited from six different recruitment centers in Puerto Rico. Individual ancestry for each subject was estimated using 44 ancestry informative markers. SES was assigned using the census tracts' median family income. Analyses of SES were based on the SES of the clinic site from which the subjects were recruited and on a subset of individuals on whom home address-based SES was available.In the two (independent) analyses, we found a significant interaction between SES, ancestry, and asthma disease status. At lower SES, European ancestry was associated with increased risk of asthma, whereas African ancestry was associated with decreased risk. The opposite was true for their higher SES counterparts.The observed interaction may help to explain the unique pattern of risk for asthma in Puerto Ricans and the lack of association with SES observed in previous studies when not accounting for varying proportions of ancestry.
INTACT RIGHT VENTRICLE-PULMONARY ARTERY SHUNT AFTER STAGE II PALLIATION IN HYPOPLASTIC LEFT HEART SYNDROME IMPROVES PULMONARY ARTERY GROWTH
Authors: Mariel E. Turner, Marc Richmond, Amee Shah, Jan Quaegebeur, Jonathan Chen, Emile Bacha, Julie Vincent
Journal: Journal of the American College of Cardiology (2012)
Hypnote and Hypnance
Authors: Ernst Schmidhofer
Journal: JAMA (1967)

To  Editor:—  Delineation of a problem may be made easier if a concise term is available to describe it.  To say, the one who is being psychoanalyzed, is in a sense clear enough in its meaning. But to impart  same meaning through use of  word  makes for brevity and specificity without sacrifice of clarity.  To say, the one who is being hypnotized, is also in a sense clear enough in its meaning. It would be desirable to impart  same meaning through  use of a word which makes for brevity and specificity without sacrifice of clarity.  I propose to offer a word for indicating quickly, facilely, and unmistakably someone who is being hypnotized or who is in a state of hypnosis. Like analysand (and habitue)  word betokens a person of either sex. That word is hypnote. And instead of seance or hypnotic trance, I
Caustic Burns From Contact With Wet Cement
Authors: Susan H. Early
Journal: JAMA (1985)

Cement is a widely used mixture in construction. A corrosive alkali, calcium hydroxide, is liberated as water is added to the lime present in the cement mixture. Skin contact for prolonged periods produces deep chemical burns with thick eschar formation. Five cases of chemical burns to the lower extremities following contact with the cement mixture are presented. When full-thickness burns were present, long periods of hospitalization were necessary for eschar separation prior to skin grafting. Early excision of full-thickness caustic burns with immediate skin grafting diminished the length of hospitalization and returned the patient to work sooner.
Phenoxybenzamine-lnduced Hyponatremia Simulating the Syndrome of Inappropriate Antidiuretic Hormone Secretion
Authors: NARCIS B. ARON
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 July 1987Phenoxybenzamine-lnduced Hyponatremia Simulating the Syndrome of Inappropriate Antidiuretic Hormone SecretionNARCIS B. ARON, M.D.NARCIS B. ARON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-1-119 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Phenoxybenzamine is an alpha-adrenergic blocking agent used in micturitional dysfunctions, especially prostatic hypertrophy (1). We present the case of a patient treated with phenoxybenzamine who developed severe hyponatremia simulating the syndrome of inappropriate antidiuretic hormone secretion (SIADH).A 73-year-old man with benign prostatic hypertrophy received phenoxybenzamine hydrochloride, 10 mg every evening for 5 days. The following morning, the patient drank about 2 L of water in 30 minutes during a urodynamic study. Four hours later, he was hospitalized with dizziness and weakness.The patient had no history of significant diseases, smoking, or drugs, except for prostatism and...References1. CAINE M. Present role of alpha adrenergic blockers in treatment of benign prostatic hypertrophy. J Urol. 1986;136:1-4. CrossrefMedlineGoogle Scholar2. SCHRIERBERL RT. Mechanism of effect of alpha adrenergic stimulation with norepinephrine on renal water excretion. J Clin Invest. 1973;52:502-11. CrossrefMedlineGoogle Scholar3. GOLDSTEINARONOWKALMAN ALS. Principals of drug action. In: The Basis of Pharmacology. 2nd ed. New York: John Wiley & Sons; 1974:2-6. Google Scholar4. KLEINLIBERMANLAKSKLEEMAN LBMC. Interrelated effects of antidiuretic hormone and adrenergic drugs on water metabolism. Am J Physiol. 1971;221:1657-65. CrossrefMedlineGoogle Scholar5. DE FRONZOBRAINECOLVINDAVIS RHMP. Water intoxication in man after cyclophosphamide therapy. Ann Intern Med. 1973;78:861-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Wolfson Hospital Holon, 58 100 Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDibenzyline Hydrochloride 63-92-3Drug-Induced Syndrome of Inappropriate Secretion of Antidiuretic HormoneDrugs affecting autonomic functions or the extrapyramidal system 1 July 1987Volume 107, Issue 1Page: 119-120KeywordsBenign prostatic hyperplasiaDrugsHyponatremiaPhenoxybenzamineProstate diseasesSyndrome of inappropriate antidiuretic hormone secretionUrodynamics Issue Published: 1 July 1987 PDF downloadLoading ...
Scan Findings in Hepatic Adenoma (Focal Nodular Hyperplasia)
Authors: PAUL MYERSON, EDWARD PROKOP, JOHN J. SZIKLAS, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1976)

Four instances of hepatic adenoma (focal nodular hyperplasia) were observed in women; 2 of the patients did not have a history of taking oral contraceptives. Three of the adenomas were characterized by areas of decreased accumulation on the 99mTc-sulfur colloid scan. The tumors were thus relatively deficient in functional reticuloendothelial cells. The fourth case, studied by means of 131I-rose bengal, revealed decreased accumulation in the tumor, as compared with the remainder of the liver. Hepatic dynamic studies were performed in 2 of the cases; one of them showed early and abundant perfusion of the hepatic adenoma. The significance of the flow, in terms of the known vascularity of the tumors, was reviewed. In the case without abundant early perfusion, biopsies revealed necrotic and hemorrhagic components. This patient was followed for 2 years, with little change in the scan appearance of the lesion. There was no accumulation of 67Ga citrate in the tumor in this case. In one patient, resection of the tumor was followed by growth of functioning hepatic tissue into the area. A review of the literature is given as to the findings in hepatic adenoma, and the role of radionuclide scans in diagnosis.
An Evaluation of Routine Follow-up Blood Screening of Infants for Phenylketonuria
Authors: Stephen J. Sepe, Harvey L. Levy, Frank W. Mount
Journal: New England Journal of Medicine (1979)

ROUTINE follow-up blood testing has been advocated for newborn phenylketonuria screening programs.1 2 3 This advocacy derives from the fact that an occasional neonate with the disorder is undetected in routine screening programs that generally use a single blood specimen obtained during the first days of life4 and from the assumption that these infants would be detected if a second or follow-up blood specimen were obtained several weeks later. It is assumed that such affected neonates are not identified from the initial blood specimen because this specimen may be obtained before enough protein has been ingested to result in demonstrable hyperphenylalaninemia.1 These . . .
Decreased Bioavailability of Digoxin Due to Antacids and Kaolin-Pectin
Authors: Donald D. Brown, Randy P. Juhl, Kathy Lewis, Mara Schrott, Brenda Bartels
Journal: New England Journal of Medicine (1976)

Employing a Latin-square design and single-dose studies of bioavailability in 10 normal human volunteers, we tested the hypothesis that antacids and kaolin-pectin might interfere with the bioavailability of orally administered digoxin. Cumulative six-day urinary digoxin excretion (expressed as the percentage of a 0.75-mg dose recovered) was: control, 40.1+/-3.0 (S.E.); aluminum hydroxide, 30.7+/-2.9; magnesium hydroxide, 27.1+/-2.4; magnesium trisilicate, 29.1+/-1.7; and kaolin-pectin 23.4+/-2.0. The differences in means were highly significant (F = 10.47, P less than 0.005). Further analysis (multiple comparison test) revealed that control differed significantly from each of the other treatments (alpha = 0.05), but there was no such difference between any of the other treatment groups. The decreased cumulative excretion produced by antacids and kaolin-pectin reflected a striking reduction in digoxin absorption associated with these compounds that was not related to alteration of gut transit time or to adsorption of digoxin to these gastrointestinal medications.
National Lung Screening Trial Findings by Age: Medicare-Eligible Versus Under-65 Population
Authors: Paul F. Pinsky, David S. Gierada, William Hocking, Edward F. Patz, Barnett S. Kramer
Journal: Annals of Internal Medicine (2014)

The NLST (National Lung Screening Trial) showed reduced lung cancer mortality in high-risk participants (smoking history of ≥30 pack-years) aged 55 to 74 years who were randomly assigned to screening with low-dose computed tomography (LDCT) versus those assigned to chest radiography. An advisory panel recently expressed reservations about Medicare coverage of LDCT screening because of concerns about performance in the Medicare-aged population, which accounted for only 25% of the NLST participants.
The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells
Authors: Guangzhi Gu, Xiaoling Gao, Quanyin Hu, Ting Kang, Zhongyang Liu, Mengyin Jiang, Deyu Miao, Qingxiang Song, Lei Yao, Yifan Tu, Zhiqing Pang, Hongzhuan Chen, Xinguo Jiang, Jun Chen
Journal: Biomaterials (2013)
Observations on Certain Forms of Disease of the Lungs
Authors: E. L. Ormerod
Journal: BMJ (1858)

THus far we have been considering pneiimonia as the chief, if not the only disease, under which the patient is labouring; but a very large and most interesting portion of the clinical history of pneumonia relates to it less as a primary disease than as a complication of other pathological conditions; for iost acute diseases, specific or otherwise, claim pneumonia as discontinuance of the mercury on November ,'5th, this was nowv DEC.119 1&58.