tbuckley/cabot-search huggingface dataset:
Jean-Pierre Christopher Midol Brookes
Authors: C. Gibbons
Journal: BMJ (2011)

<h3>ABSTRACT</h3> <h3>Objective</h3> Advance care planning (ACP) can support patients in achieving current and future medical care that aligns with their values and goals. In primary care, a lack of standardized processes hinders implementation of ACP conversations. This study reports a quality improvement process to identify and engage patients and clinicians in ACP. <h3>Methods</h3> Primary care clinicians received training in conversations based on the Serious Illness Conversation Guide and tools to support ACP. In December 2019, patients 65 years of age and older with chronic obstructive pulmonary disease were systematically identified, mailed ACP resources and telephoned by the clinic to invite them to an ACP appointment. We tracked the attendance of the patients and evaluated patient experience using a survey. <h3>Results</h3> Of the 91 patients telephoned, 50 were reached, and 27 attended the appointment. Further efforts were suspended in March 2020 due to the COVID-19 pandemic. Thirteen patients completed the survey. There were statistically significant increases in the patient’s perception of being heard and understood by their physician, feeling hopeful about quality of life and feeling peaceful. <h3>Conclusion</h3> This study provides evidence that with training, tools and processes, patients and primary care clinicians can be effectively engaged in ACP conversations. <h3>KEY MESSAGES</h3> <h3>What was already known?</h3> Training resources exist for help clinicians enhance their advance care planning communication skills Besides a need for skills, other practical challenges exist in implementing advance care planning in family practice <h3>What are the new findings?</h3> Structured patient identification and preparation can facilitate advance care planning conversations in family practice Patients reported positive experiences of the conversations <h3>What is their significance?</h3> Clinical: It is important to move beyond clinician training alone to implement processes in family practice to trigger advance care planning conversations Research: Further research to identify effective scalable approaches to triggering and implementing advance care planning conversations in family practice would be beneficial
Serum IgE levels and allergic spectra in immigrants to Sweden
Authors: A. F. Kalyoncu, G. Stålenheim
Journal: Allergy (1992)

We evaluated the allergy status of 134 immigrants from Asia, Africa, the Middle East and South America, who were referred to our clinic during the past 10 years. Fifty Swedish patients were used for comparison. When the atopy state was not taken into account, no significant difference was found between the two groups with respect to total IgE levels. However, IgE levels of non‐atopic immigrants were significantly higher than the IgE levels of non‐atopic Swedes. While there was no significant difference in IgE levels between atopic and non‐atopic immigrants, this difference was significant in Swedish patients. In general, IgE levels of immigrants showed a decline with time and reached approximately the same levels as for the Swedish patients in 10.5 years. In the immigrant group atopic women had a considerably lower IgE level than the atopic men. Among the atopics there were no differences between sexes. In Swedes and immigrants pollen was the most common group of allergens. The spectrum of allergy in the immigrant group changed with time in Sweden, and gradually became more similar to the Swedish spectrum. Skin and/or RAST positivity to birch increased from 16% within 2.5 years to 53% after more than 10.5 years in Sweden. Our data indicate that environmental factors rather than hereditary differences determine the IgE state. Within a few years the immunologic status of immigrants adapts to the new environment.
Effects of balloon angioplasty and stent implantation on intrarenal echo-Doppler velocimetric indices
Authors: Ivana Marana, Flavio Airoldi, Larry Burdick, Cristina Alberti, Andrea Lovaria, Silvia Saccheri, Gabriella Gazzano, Simone Palatresi, Barbara Nador, Lucia Turolo, Alberto Morganti
Journal: Kidney International (1998)
Neurological Complications in the Preicteric Stage of Infectious Hepatitis.
Authors: Benjamin Brooks
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Neurological Complications in the Preicteric Stage of Infectious Hepatitis.Benjamin Brooks, M.D., Radmila Klasnja, M.D., Mirjana Mocic, M.D., Andjelija Kostic, M.D.Benjamin Brooks, M.D.Search for more papers by this author, Radmila Klasnja, M.D.Search for more papers by this author, Mirjana Mocic, M.D.Search for more papers by this author, Andjelija Kostic, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-878_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeurological complications in the preicteric stage of infectious hepatitis occur rarely. The initial clinical studies that described these unique cases in detail lacked the modern virological armamentarium that would affirm that no other virus was responsible for the clinical picture of meningismus or meningitis. In the 3-year period of 1966 to 1968, inclusively, 2624 patients with heterophile-negative infectious hepatitis were hospitalized in the Infectious Disease Clinics of the Medical Faculty of the University of Belgrade, Yugoslavia, during the epidemics of hepatitis. Three of these patients presented with signs of meningismus, meningitis, or, in one case, signs of increased intracranial pressure... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass., and Belgrade, Yugoslavia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 878-878KeywordsHepatitisInfectious diseasesInfectious hepatitisMeningitis Issue Published: 1 May 1972 PDF DownloadLoading ...
Evolution of Clinical Signs in Adult-Onset Cystic Disease of the Renal Medulla
Authors: KENNETH D. GARDNER
Journal: Annals of Internal Medicine (1971)

Cystic disease of the renal medulla and familial juvenile nephronophthisis, once held to be separate diseases, have been considered a single entity in recent years. Evidence that favors the earlier opinion was obtained in this retrospective and prospective study of two kindreds in whom renal disease characterized by medullary cysts has affected members of three successive generations. In age at onset, duration, and pattern of inheritance the disease is different from that described in most accounts of familial renal disease in which renal medullary cysts are documented. Because of these differences and because separate recognition has significant practical advantages, such as assuring accuracy during genetic counseling of members from affected families, a return to the recognition of adult-onset cystic disease of the renal medulla and familial juvenile nephronophthisis as distinct clinical entities is desirable.
Wolfram's Syndrome: A Clinical, Diagnostic, and Interpretative Contribution
Authors: C Blasi, F Pierelli, E Rispoli, M Saponara, E Vingolo, D Andreani
Journal: Diabetes Care (1986)

Four cases (belonging to two different families) of Wolfram's syndrome (WS), a rare congenital disease characterized in its complete form by insulin-dependent diabetes mellitus, optic atrophy, diabetes insipidus, deafness, and dilation of the urinary tracts are presented, and a review of the literature is included. Three of four patients are characterized by HLA-DR2 haplotype, which is rare in IDDM. The neurodegenerative nature of some symptoms and the possible pathogenesis of diabetes mellitus connected with it are discussed.
Supracortical consciousness: Insights from temporal dynamics, processing-content, and olfaction
Authors: Ezequiel Morsella, John A. Bargh
Journal: Behavioral and Brain Sciences (2007)

To further illuminate the nature of conscious states, it may be progressive to integrate Merker's important contribution with what is known regarding (a) the temporal relation between conscious states and activation of the mesodiencephalic system; (b) the nature of the information (e.g., perceptual vs. premotor) involved in conscious integration; and (c) the neural correlates of olfactory consciousness.
Misuse of statistical methods: critical assessment of articles in BMJ from January to March 1976.
Authors: S M Gore, I G Jones, E C Rytter
Journal: BMJ (1977)

Sixty-two reports that appeared as Papers and Originals (excluding short reports) in 13 consecutive issues of the British Medical journal included statistical analysis. Thirty-two had statistical errors of one kind or another; in 18 fairly serious faults were discovered. The summaries of five reports made some claim that was unsupportable on re-examination of the data. Medical investigators should consult with people who have a real understanding of statistical methods throughout their projects.
The Silent Man
Authors: John F. Stamler
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sex differences in human brain asymmetry: a critical survey
Authors: Jeannette McGlone
Journal: Behavioral and Brain Sciences (1980)

Abstract Dual functional brain asymmetry refers to the notion that in most individuals the left cerebral hemisphere is specialized for language functions, whereas the right cerebral hemisphere is more important than the left for the perception, construction, and recall of stimuli that are difficult to verbalize. In the last twenty years there have been scattered reports of sex differences in degree of hemispheric specialization. This review provides a critical framework within which two related topics are discussed: Do meaningful sex differences in verbal or spatial cerebral lateralization exist? and, if so, Is the brain of one sex more symmetrically organized than the other? Data gathered on right-handed adults are examined from clinical studies of patients with unilateral brain lesions; from dichotic listening, tachistoscopic, and sensorimotor studies of functional asymmetries in non-brain-damaged subjects; from anatomical and electrophysiological investigations, as well as from the developmental literature. Retrospective and descriptive findings predominate over prospective and experimental methodologies. Nevertheless, there is an impressive accummulation of evidence suggesting that the male brain may be more asymmetrically organized than the female brain, both for verbal and nonverbal functions. These trends are rarely found in childhood but are often significant in the mature organism.
The poverty of expectation
Authors: Des Spence
Journal: BMJ (2007)

My father went bankrupt in 1972. The times were different then, and personal bankruptcy was neither commonplace nor a mere social inconvenience. My family was sent tumbling down into a black financial abyss. We fell, but rather than hit the bottom, we were caught in a safety net—the welfare state. This educated me, fed me, clothed me, housed me, paid for my university education, and supported my studies. A debt of gratitude to society lives with me everyday. There is nothing that I would not do to protect our welfare state—for me it is …
Smallpox Reported in the United States
Authors: C. Henry Kempe
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Following the importation of a suspected case of smallpox from Ghana to Washington, DC, early in May of 1965, extensive and detailed descriptions of the public health management of the many contacts of the suspected case appeared on the front pages of such diverse publications as the<i>AMA News, Modern Medicine, Medical Tribune, Antibiotic News</i>, and others. Almost all 50 state health officers in their monthly bulletins to the physicians in their state described the importation in detail by use of the official publication of the weekly reports from the Communicable Disease Center in Atlanta. It is fair to say that, by now, virtually every physician in the United States will have heard that there was an importation of smallpox confirmed by the Communicable Disease Center laboratory. The fact is that the lady in question suffered from chickenpox and that a clinical suspicion was followed by an
Abstract LB-431: Augmented induction of tumor antigen-specific CTL by cetuximab in head and neck cancer patients does not correlate with Fcγ receptor IIIa genotype, but relies on NK:DC cross talk mediated by interferon-γ and NKG2D
Authors: Christopher A. Lord, Raghvendra M. Srivastava, Steve C. Lee, Pedro A. Andrade Filho, Sandra P. Gibson, William E. Gooding, Soldano Ferrone, Robert L. Ferris
Journal: Cancer Research (2012)

Abstract Despite over-expression of epidermal growth factor receptor (EGFR) in 80-90% of head and neck cancers (HNC), only ∼20% of HNC patients are clinically responsive to treatment with the EGFR-specific monoclonal antibody (mAb) cetuximab. To date, no reliable biomarker of clinical efficacy has been identified to predict clinical response to cetuximab therapy in HNC. Modest, yet statistically significant correlations of Fcγ receptor (FcγR) IIIa polymorphisms with clinical outcome have been noted in B cell lymphoma, breast, and colorectal cancer patients treated with rituximab, trastuzumab, and cetuximab, respectively. Therefore, we have investigated whether a known FcγRIIIa polymorphism in natural killer (NK) cells at amino acid position 158 (valine [V] vs. phenylalanine [F]) correlates with the anti-tumor activity of cetuximab in immunodeficient mice engrafted with human HNC tumors as well as with the induction of EGFR-specific cytotoxic T lymphocytes (CTL) and clinical course in HNC patients treated with cetuximab. When injected into immunodeficient mice, human NK cells expressing the V allele at this position demonstrated significantly greater ability to control the growth of xenografted HNC tumors. However, we did not find a significant correlation between FcγRIIIa genotype and disease free survival (p=0.683) in a cohort of 107 consecutive HNC patients treated with regimens incorporating cetuximab. Furthermore, we demonstrate for the first time that in the presence of cetuximab-opsonized HNC cells, NK cells trigger maturation of dendritic cells (DC), leading to augmented TA-specific cross-priming of EGFR and MAGE-specific CTL in vitro, and in vivo in cetuximab-treated HNC patients. The significantly higher frequencies of EGFR-specific CTL we found in HLA-A2+ PBMC from cetuximab-treated HNC patients relative to cetuximab-naive HNC patients (p&amp;lt;0.001) also did not correlate with FcγRIIIa genotype, but their induction was dependent on NK:DC cross talk mediated by interferon-γ and NKG2D. Taken together, our data indicate that cetuximab treatment augments the priming of both EGFR and non-EGFR TA-specific cellular immunity in vivo, thereby providing a novel immune mechanism for enhanced anti-tumor activity of TA-specific mAb relevant to clinical response, as well as a potential biomarker for monitoring this response in mAb-treated cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-431. doi:1538-7445.AM2012-LB-431
Deprivation affects more than half of the world's children
Authors: Susan Mayor
Journal: BMJ (2004)

More than half of the children in the world live in extreme deprivation due to poverty, war, and HIV/AIDS, warns a report published this week by the Unicef, which argues that these problems are impeding the development of the countries affected. The report also provides a complete almanac of up to date statistical data on children.



Children experience poverty differently from adults, and the standard measures of income or consumption fail to capture the impact of …
EPSTEIN-BARR VIRUS INFECTIONS IN THE X-LINKED RECESSIVE LYMPHOPROLIFERATIVE SYNDROME
Authors: DavidT. Purtilo, Jag Bhawan, LindseyM. Hutt, Lucian Denicola, Irma Szymanski, JamesP.S. Yang, William Boto, Rorert Maier, David Thorley-Lawson
Journal: The Lancet (1978)
Hyperlipemia and Atheromatosis in a Hibernator, Citellus columbianus
Authors: JOSEPH H. BRAGDON
Journal: Circulation Research (1954)

Ground squirrels occasionally show extreme hyperlipemia. Triglycerides predominate, but high levels of cholesterol and phospholipids also occur. Evidence is presented indicating that the hyperlipemia results from periods of dietary caloric excess. During hibernation the triglyceride levels are low. Atheromata were found in the aorta and endocardium in those animals with the highest cholesterol levels.
Plant based vaccines move a step closer
Authors: J. Wise
Journal: BMJ (1998)

In the future eating a potato or banana will not just provide nutrients but may also provide protection against infectious diseases. The first clinical trials of plant based immunotherapies show that this technology is very close to application.

In one study Julian Ma and colleagues from Guy's Hospital, London, engineered a tobacco plant to produce antibodies against Streptococcus mutans —an oral bacterial infection that contributes to dental caries (Nature Medicine 1998;4:601-6). When they applied a solution of the antibody to subjects' teeth—which had previously been sterilised—they found …
Sanitation, Spirits, and Medicine: Health Care in the African Bush
Authors: Gary S. Ferenchick
Journal: JAMA (1989)

Liberia, situated on the western bulge of Africa, is that continent's oldest independent black republic. Located 480 km north of the equator and bordered by Sierra Leone, the Ivory Coast, Guinea, and the Atlantic Ocean, Liberia is nearly the size of Ohio, with an estimated population of 2 million. Most Liberians belong to 1 of 16 distinct ethnic groups, each with a separate culture and language. Two thirds of the population is rural and 50% of the population is under 15 years of age. The estimated adult illiteracy rate is 76%.<sup>1</sup> The village of Zorzor lies in a tropical rain forest in the foothills of the Wologizi mountain range, which extends from northeast Liberia into Guinea. Zorzor, a rural village, has an estimated population of 5000 to 10 000 and is 220 km from Monrovia, the Liberian capital (Figure). Subsistence rice farming is the primary local occupation of the
Function Keys in EKG Primer
Authors: MYO THANT
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 March 1986Function Keys in EKG PrimerMYO THANT, M.D.MYO THANT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-449_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There are some points that we would like to clarify in the review ofEKG Primerin the October issue (1). The complete summary of the function keys can be displayed by pressing F1. This is a help file that the user can refer to any time for help. It is also possible to look back at the previous electrocardiogram in the quiz section. All that is required is to press function key F7....Reference1. EKG Primer—A Computer Textbook [Software review]. Ann Intern Med. 1985;103:648. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MYO THANT, M.D.Affiliations: Information Systems for Medicine, Inc. Phoenix, MD 21131 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1986Volume 104, Issue 3Page: 449-449KeywordsElectrocardiography ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...
Rate of Progression of Coronary Atherosclerotic Plaque in Women
Authors: Stephen J. Nicholls, Kathy Wolski, Ilke Sipahi, Paul Schoenhagen, Timothy Crowe, Samir R. Kapadia, Stanley L. Hazen, E. Murat Tuzcu, Steven E. Nissen
Journal: Journal of the American College of Cardiology (2007)
Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage
Authors: Heda Kvakan, Markus Kleinewietfeld, Fatimunnisa Qadri, Joon-Keun Park, Robert Fischer, Ines Schwarz, Hans-Peter Rahn, Ralph Plehm, Maren Wellner, Saban Elitok, Petra Gratze, Ralf Dechend, Friedrich C. Luft, Dominik N. Muller
Journal: Circulation (2009)

Hypertensive target organ damage, especially cardiac hypertrophy with heart failure and arrhythmia, is a major source of morbidity and mortality. Angiotensin II, a major mediator of hypertension and cardiac damage, has proinflammatory properties. Inflammation and activation of the immune system play a pivotal role in pathogenesis of hypertensive target organ damage. However, the role of immunosuppressive CD4+CD25+ regulatory T (Treg) cells in the pathogenesis of hypertensive target organ damage is unexplored.We conducted adoptive transfer of Treg cells into angiotensin II-infused hypertensive mice. Treg cell recipients exhibited improved cardiac hypertrophy and less cardiac fibrosis despite sustained hypertension. Amelioration of cardiac morphology was accompanied by an improvement in arrhythmogenic electric remodeling, indicating the functional significance of the enhanced cardiac morphology. Delocalization of the connexin 43 gap junction protein is one of the major pathomechanisms in electric remodeling. Pronounced connexin 43 immunoreactivity was found at the lateral borders of cardiomyocytes in angiotensin II-treated mice. In contrast, connexin 43 was restricted to the intercalated disk regions in sham controls. Surprisingly, angiotensin II+Treg-treated mice showed normal connexin 43 gap junction protein localization. Adoptive Treg cell transfer resulted in a marked reduction in cardiac CD4+, CD8+, and CD69+ cell and macrophage infiltration.Immunosuppressive effects of transferred Treg cells ameliorated cardiac damage and accounted for the improved electric remodeling independently of blood pressure-lowering effects. Our results provide new insights into the pathogenesis of hypertensive cardiac damage and could therefore lead to new therapeutic approaches that involve manipulation of the immune system.