tbuckley/cabot-search huggingface dataset:
Psychological Factors in Alcoholic Women
Authors: HOWARD P. WOOD, EDWARD L. DUFFY
Journal: American Journal of Psychiatry (1966)

We have presented data on 69 female alcoholics who have had three or more interviews. Almost all are of high socioeconomic status. The majority are Protestant and college-educated. They drink at home and do not come to the attention of public agencies. Their childhoods were invariably disturbed, with a dependent relationship toward a cold, dominant parent, usually the mother. Half the fathers were alcoholic. Many patients felt an identification with the father rather than the mother. All patients grew up feeling inadequate and worthless and unable to express their hostility directly. Marital disharmony appeared to be the most frequent factor perpetuating our patient's alcoholism, though many had drunk heavily before marriage. The marriages were troubled by inadequate emotional communication and poor sexual adjustment. Nevertheless, they were remarkably long-lasting and free of infidelity. The husbands were usually overtly domineering but invariably controlling and unable to express feelings. Patients who remained single had retained the ambivalent dependent relationship toward one or both parents. Alcohol, initially the "enabling drug" which provided the missing feelings of adequacy and acceptability, became later the releaser of hostility, tool of revenge, and means of self-punishment. All patients exploded their anger when drunk. The following modal pattern appeared in 27 of our cases: cold domineering mother, warmer but alcoholic father, "miserable self-image," cold domineering husband, resort to alcohol patterned after father's drinking. We have speculated on what basic factors may be crucial to the development of alcoholism in an individual woman.
Portacaval Shunt in Three Children With Alpha–1–Antitrypsin Deficiency and Cirrhosis: 9 to 12⅓ Years Later
Authors: Thomas E. Starzl, Kendrick A. Porter, Ronald W. Busuttil, Rudolph Pichlmayr
Journal: Hepatology (1990)

HepatologyVolume 11, Issue 1 p. 152-154 CorrespondenceFree Access Portacaval shunt in three children with alpha-1-antitrypsin deficiency and cirrhosis: 9 to 12⅓ years later Thomas E. Starzl M. D., Ph.D., Corresponding Author Thomas E. Starzl M. D., Ph.D. Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213Department of Surgery, 3601 Fifth Ave., Falk Clinic 4 West, Pittsburgh, Pennsylvania 15213===Search for more papers by this authorKendrick A. Porter M. D., Kendrick A. Porter M. D. Department of Pathology, St. Mary's Hospital and Medical School, University of London London, W2 1PG, EnglandSearch for more papers by this authorRonald W. Busuttil M. D., Ph.D., Ronald W. Busuttil M. D., Ph.D. Department of Surgery UCLA School of Medicine Los Angeles, CA 90024Search for more papers by this authorRudolph Pichlmayr M. D., Ph.D., Rudolph Pichlmayr M. D., Ph.D. Department of Surgery University of Hannover D-3000 Hannover 61, West GermanySearch for more papers by this author Thomas E. Starzl M. D., Ph.D., Corresponding Author Thomas E. Starzl M. D., Ph.D. Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213Department of Surgery, 3601 Fifth Ave., Falk Clinic 4 West, Pittsburgh, Pennsylvania 15213===Search for more papers by this authorKendrick A. Porter M. D., Kendrick A. Porter M. D. Department of Pathology, St. Mary's Hospital and Medical School, University of London London, W2 1PG, EnglandSearch for more papers by this authorRonald W. Busuttil M. D., Ph.D., Ronald W. Busuttil M. D., Ph.D. Department of Surgery UCLA School of Medicine Los Angeles, CA 90024Search for more papers by this authorRudolph Pichlmayr M. D., Ph.D., Rudolph Pichlmayr M. D., Ph.D. Department of Surgery University of Hannover D-3000 Hannover 61, West GermanySearch for more papers by this author First published: January 1990 https://doi.org/10.1002/hep.1840110133Citations: 11AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume11, Issue1January 1990Pages 152-154 ReferencesRelatedInformation
The European Thoracic Oncology Platform Lungscape Project: A Way to Bridge Non-Small Cell Lung Cancer Molecular Characteristics and Clinical Data
Authors: S. Peters, O. Dafni, L. Bubendorf, P. Meldgaard, K. O'Byrne, A. Wrona, W. Weder, M. Canela, S. Malatesta, J. Vansteenkiste, A-M. Dingemans, M. Nicolson, S. Savic, P. Baas, R. Peck, S. Lu, E. Smit, E. Jantus-Lewintre, R. Rosell, R.A. Stahel, Y. Miyata, T. Furukawa, Y. Tsutani, T. Mimae, K. Misumi, T. Yoshiya, Y. Ibuki, M. Okada, H. Yoshioka, Y. Iwamoto, S. Ito, T. Yamanaka, H. Tada, M. Yoshimura, I. Okamoto, I. Yoshino, K. Nakagawa, Y. Nakanishi, J. Pujol, T. De Pas, A. Rittmeyer, B. Kubisa, E. Vallieres, E. Levchenko, B. Salaun, N. Vanhoutte, M. Debois, V. Brichard, R. Califano, M. Caramanti, R. Berardi, A. Santinelli, A. Brunelli, A. Savini, P. Mazzanti, C. Pompili, M. Salati, C. Pierantoni, S. Cascinu, V. Ludovini, G. Bellezza, F. Bianconi, R. Chiari, C. Bennati, F.R. Tofanetti, J. Vannucci, F. Puma, A. Sidoni, L. Crinò, K. Honda, R. Noro, N. Miura, K. Tsuta, G. Ishii, H. Tsuda, A. Gennma, H. Asamura, K. Nagai, T. Yamada, G. Toyokawa, T. Ohba, K. Sugio, Y. Morodomi, T. Takenaka, M. Yamaguchi, F. Hirai, K. Taguchi, T. Seto, Y. Ichinose, R. Nakahara, H. Suzuki, S. Igarashi, H. Matsuguma, J. Bosch-Barrera, X. Baldo, M. Rubio, M. Buxó, L. Vilardell, R. Porta, E. Marmol, N. Basté, A. Izquierdo, F. Sebastian, J. Mazieres, I. Rouquette, B. Lepage, J. Milia, P. Validire, P. Hofman, M. Beau-Faller, L. Brouchet, P. Fouret
Journal: Annals of Oncology (2012)
Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling
Authors: J. D. Molkentin
Journal: Journal of Clinical Investigation (2006)

Ca2+ plays a pivotal role in both excitation-contraction coupling (ECC) and activation of Ca2+-dependent signaling pathways. One of the remaining questions in cardiac biology is how Ca2+-dependent signaling pathways are regulated under conditions of continual Ca2+ transients that mediate cardiac contraction during each heartbeat. Ca2+-calmodulin-dependent protein kinase II (CaMKII) activation and its ability to regulate histone deacetylase 5 (HDAC5) nuclear shuttling represent a critical Ca2+-dependent signaling circuit for controlling cardiac hypertrophy and heart failure, yet the mechanism of activation by Ca2+ is not known. In this issue of the JCI, Wu et al. convincingly demonstrate that the inositol 1,4,5-trisphosphate receptor (InsP3R) is involved in local control of Ca2+ for activating CaMKII in the nuclear envelope of adult ventricular cardiac myocytes (see the related article beginning on page 675). The overall paradigm that is demonstrated is the best example of a molecular mechanism whereby signaling is directly regulated by a local Ca2+ pool that is disparate or geometrically insensitive to cytosolic Ca2+ underlying each contractile cycle.
Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes
Authors: Juliana Chan, Ying Wang
Journal: Diabetes Care (2004)

We thank Ng et al. (1) for their response to our recent article on the associations of two aldose reductase gene polymorphisms, a (CA)n microsatellite at the 5′ region and a promoter C/T polymorphism with nephropathy and retinopathy in type 2 diabetes (2).

However, we hold the view that Ng et al. have misinterpreted our data …
Case 42-1969
Authors: Allan I. Sandler, Roger A. Williams
Journal: New England Journal of Medicine (1969)

Presentation of Case First admission. A seventy-two-year-old woman was brought to the hospital by the police because of paranoid symptoms. She called the police to report that her neighbors were going to kill her.During the previous year she had exertional dyspnea, orthopnea and peripheral edema. She took an unspecified medication because of nocturnal pains in the legs and a diuretic agent for edema of the legs, as well as a variety of medications in an attempt to lose weight and propoxyphene-hydrochloride (Darvon) for arthralgias.Twenty years previously a hysterectomy had been performed because of carcinoma of the endometrium. Subsequently, . . .
Cardiac autonomic dysfunction in diabetic children.
Authors: M M Massin, B Derkenne, M Tallsund, D Rocour-Brumioul, C Ernould, M C Lebrethon, J P Bourguignon
Journal: Diabetes Care (1999)

Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can be used to detect subclinical autonomic neuropathy in diabetic children.We examined five time domain and three frequency domain HRV indices determined from 24-h Holter recordings in 73 diabetic children and adolescents aged 3-18 years (mean 12.1 years) with a mean duration of diabetes of 55 months. The measures were compared with normal ranges. Z scores were established for each parameter and were compared with classic risk factors of other diabetic complications.Most HRV indices were significantly depressed in children aged > or = 11 years, and the levels of HRV abnormalities were significantly correlated with long-term metabolic control (mean GHb for 4 years) in that age-group. In younger patients, HRV indices were within the normal range and were not correlated with the level of metabolic control. Illness duration and microalbuminuria but not short-term metabolic control (most recent GHb) were also independently predictive of HRV abnormalities.These results suggest that early puberty is a critical period for the development of diabetic cardiac autonomic dysfunction. Therefore, all type 1 diabetic patients should be screened for this complication by HRV analysis beginning at the first stage of puberty regardless of illness duration, microalbuminuria, and level of metabolic control.
Kinetic modeling and mathematical analysis indicate that acute phase gene expression in Hep 3B cells is regulated by both transcriptional and posttranscriptional mechanisms.
Authors: S L Jiang, D Samols, D Rzewnicki, S S Macintyre, I Greber, J Sipe, I Kushner
Journal: Journal of Clinical Investigation (1995)

To evaluate the possible role of posttranscriptional mechanisms in the acute phase response, we determined the kinetics of transcription (by nuclear run-on assay) and mRNA accumulation of five human acute phase genes in Hep 3B cells incubated with conditioned medium from LPS-stimulated monocytes. Increase in mRNA accumulation was comparable to increase in transcription rate for fibrinogen-alpha and alpha-1 protease inhibitor, suggesting largely transcriptional regulation. In contrast, mRNA accumulation was about 10-20-fold greater than transcriptional increase for serum amyloid A, C3, and factor B, suggesting participation of posttranscriptional mechanisms. Since finding a disparity between the magnitudes of increase in mRNA and transcription does not definitively establish involvement of posttranscriptional mechanisms, we subjected our data to modeling studies and dynamic mathematical analysis to evaluate this possibility more rigorously. In modeling studies, accumulation curves resembling those observed for these three mRNAs could be generated from the nuclear run-on results only if posttranscriptional regulation was assumed. Dynamic mathematical analysis of relative transcription rates and relative mRNA abundance also strongly supported participation of posttranscriptional mechanisms. These observations suggest that posttranscriptional regulation plays a substantial role in induction of some, but not all acute phase proteins.
False-Positive Liver Scan Following Colectomy
Authors: Tapan K. Chaudhuri
Journal: JAMA (1975)

To the Editor.—  The purpose of this letter is to report an interestingly abnormal liver scan in a normal liver. A falsely abnormal liver scan was obtained in a patient following total colectomy. True normalcy of the liver in this case was confirmed by liver function tests, liver biopsy, and, finally, laparotomy. To our knowledge, this type of observation has not previously been reported in the literature.  A 27-year-old man with Crohn disease and carcinoma of the colon underwent total colectomy. His preoperative liver scan (Figure, top) was within normal limits. The postoperative liver scan (Figure, bottom) was apparently abnormal, characterized by heterogeneous colloid uptake and focal defects in the liver and increased splenic uptake. This may erroneously be attributed to parenchymal liver disease with possible portal hypertension. In this patient, however, there was no disease in the liver, as evidenced by normal liver function tests, liver biopsy, and laparotomy.
Abstract 5234: Sequential multi-modality imaging to detect metabolic changes during tumor growth
Authors: Inna Serganova, Maxim Moroz, Asif Rizwan, Xiaohui Ni, Ekaterina Moroz, Jason Koutcher, Ronald Blasberg
Journal: Cancer Research (2010)

Abstract The expression and activity of lactate dehydrogenase A (LDH-A) in malignant tissue is considered a prognostic marker of poor outcome in many tumors. A limitation of tissue LDH-A measurements is the requirement of tissue for assay. The development of new non-invasive methods is highly demanded for clinical evaluation. One mechanistic link between tumor cell metabolism and the activity of lactate dehydrogenase A (LDH-A) is based on the HIF-1 transcription factor and its upregulation in tumors. HIF-1 binds to the LDH-A promoter and increases LDH-A expression; this in turn results in increased lactic acid production. The objective of this study was to detect the metabolic changes during tumor growth using a multi-modality imaging approach. To monitor HIF-1 pathway activity by bioluminescence imaging (BLI), we cloned an external Gaussia luciferase (exGLuc) reporter gene into an -IRES-GFP cassette, and placed the cassette in a self-inactivated retroviral vector under the control of an enhancer, containing multiple copies of the binding sites for the HIF-1 transcription factor. 18F-fluorodeoxyglucose (FDG)/microPET imaging was used for the detection of glucose metabolism in tumors, while lactate production was measured by proton magnetic resonance spectroscopic imaging (MRI/S). To validate this multi-modality imaging approach, human glioblastoma U87MG cells were transduced with the HIF-1 reporter vector and the HIF-1 reporter response was validated in vitro by exposure cells to hypoxia (1% O2) and to CoCl2 or DFO (deferoxamine mesylate). Despite a high basal level of HIF-1 transcriptional activity in the U87MG reporter cells, a strong correlation between oxygen deprivation and the level of exGLuc/GFP expression (indicating HIF-1 transcriptional activation) was detected, and this increase corresponded with a significant increase in LDH-A expression, assessed by immunoblotting. In vivo experiments using U87 reporter-xenografts also demonstrated a correspondence between the levels of HIF-1 expression and lactate production assessed by MRI/S. The measurement of lactate production using MRI/S with consecutive BLI imaging of HIF-1 activity and 18F fluorodeoxyglucose (FDG)/microPET confirmed the feasibility of a multi-modality imaging approach to study the link between the HIF-1 activity and a lactate production, as well as the level of glucose (FDG) uptake in growing xenografts. This multi-modal imaging paradigm can provide new and relevant information, and the opportunity to initiate and monitor more effective treatment strategies to arrest tumor growth. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5234.
The Ethics of Using Web Technology To Find Research Participants
Authors: Roy B. Jones
Journal: Annals of Internal Medicine (1999)

Letters2 February 1999The Ethics of Using Web Technology To Find Research ParticipantsRoy B. Jones, PhD, MDRoy B. Jones, PhD, MDUniversity of Colorado Health Sciences Center; Denver, CO 80262Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-3-199902020-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article by de Groen and colleagues (1) and its accompanying editorial (2) provide excellent examples of the power of the Internet and networked computing to enhance data retrieval for health care research and practice. Unfortunately, they also illustrate potential pitfalls: violation of patient's privacy and abuse of the research method.Direct solicitation of patients to participate in treatment research and using billing records to collate research data, both done without prior permission of the patient, are overt aims and outcomes of the method. This seems to violate accepted guidelines for clinical research. The collation of “practice ...References1. de Groen PC, Barry JA, Schaller WJ. Applying World Wide Web technology to the study of patients with rare diseases. Ann Intern Med. 1998;129:107-13. LinkGoogle Scholar2. Shortliffe EH. Health care and the next generation Internet [Editorial]. Ann Intern Med. 1998;129:138-40. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Colorado Health Sciences Center; Denver, CO 80262 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoApplying World Wide Web Technology to the Study of Patients with Rare Diseases Piet C. de Groen , Jon A. Barry , and William J. Schaller The Ethics of Using Web Technology To Find Research Participants Piet C. de Groen Metrics 2 February 1999Volume 130, Issue 3Page: 245KeywordsHealth services researchInformation storage and retrievalInternetResearch designResearch reporting guidelines Issue Published: 2 February 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Gestational Diabetes Mellitus — Time to Treat
Authors: Michael F. Greene, Caren G. Solomon
Journal: New England Journal of Medicine (2005)

Gestational diabetes mellitus, broadly defined as carbohydrate intolerance beginning or first recognized during pregnancy,1,2 was originally described decades ago and has since been the subject of extensive research. Yet the most recent guidelines of the U.S. Preventive Services Task Force, noting the absence of data to establish a clear link between screening and improved outcomes of affected pregnancies, concluded that “the evidence is insufficient to recommend for or against routine screening for gestational diabetes.”3 The American College of Obstetricians and Gynecologists officially recommends screening for and treatment of gestational diabetes but acknowledges that these recommendations are based on “limited . . .
Averting Traumatic Injury to Trauma Care in Los Angeles
Authors: Dennis P. Andrulis
Journal: JAMA (1996)

The crisis facing the health care system in Los Angeles County has threatened to engulf a critical part of the city's and the area's essential services—trauma care provided at the Los Angeles County+University of Southern California (LAC+USC) Medical Center. Though averted at this time, it should serve as a clarion call to communities across the country that a similar consequence could befall them if they do not take heed from the Los Angeles County experience. The circumstances described in the article by Cornwell and colleagues in this issue ofThe Journaldescribe a brush with fate that has far-reaching ramifications.<sup>1</sup>In portraying the nature of trauma care, this article brings home the fact that institutional providers of such services touch people from all walks of life—rich and poor, inner city, suburban and rural residents—who deserve treatment in the best trauma care setting. In addition, as stated, action that reduces
Landmark perspective. Pernicious anemia
Authors: W. H. Crosby
Journal: JAMA (1983)

The article by Minot and Murphy<sup>1</sup>had two profound effects on the history of medicine. It presented an effective therapy for a uniformly fatal blood disease and it revolutionized the study of the blood. In 1934, its authors, together with George Whipple, received the Nobel Prize in medicine, the first time it was ever awarded to physicians from the United States. George Richards Minot, the 40-year-old architect of this research, was chief of the medical service at the Huntington Memorial Hospital, a cancer hospital in Boston. William P. Murphy, aged 34 years, in private practice in Brookline, was a junior associate in medicine at the Peter Bent Brigham Hospital who was invited by Minot to participate.<sup>2</sup>Murphy provided access to the patients with pernicious anemia at the Brigham, supervised their therapy, and performed the essential counting of reticulocytes. Minot had learned years before that a reticulocyte crisis heralds
<b>Aid agencies provide medical relief in Kenya</b>
Authors: John Zaracostas
Journal: BMJ (2008)

The International Committee of the Red Cross and United Nations relief agencies are providing emergency medical and food assistance to more than 100 000 people displaced by the ongoing violence in Kenya, especially in the Rift Valley, in which hundreds of people are reported to have been killed or injured and tens of thousands have been forced to flee their homes.
WHO Director-General replies to the BMJ
Authors: M. Chan
Journal: BMJ (2010)

In her editorial accompanying the feature on conflicts of interest at the World Health Organization,1 2 Godlee notes that it is “almost certainly true” that the mildness of the H1N1 pandemic, compared with the severity long expected from a virus like H5N1, has contributed to the current critical scrutiny of WHO’s decisions. As the editorial further states, this reality does not make it wrong to ask hard questions.

We fully agree. Good investigative journalism brings problems, and their potential consequences, into sharp focus and identifies the need for remedial action. Potential conflicts of interest are inherent in any relationship between a normative and health development agency, such as WHO, and profit driven industry. WHO needs to establish, and enforce, stricter rules of engagement with industry, and we are doing so. However, let me be …