Aphthous Ulceration of the Gastrointestinal Tract in Patients with the Acquired Immunodeficiency Syndrome (AIDS)
Authors: Michael C. Bach
Journal: Annals of Internal Medicine (1990)

Brief Reports15 March 1990Aphthous Ulceration of the Gastrointestinal Tract in Patients with the Acquired Immunodeficiency Syndrome (AIDS)Michael C. Bach, MD, Douglas A. Howell, MD, August J. Valenti, MD, Thomas J. Smith, MD, Dean L. Winslow, MDMichael C. Bach, MD, Douglas A. Howell, MD, August J. Valenti, MD, Thomas J. Smith, MD, Dean L. Winslow, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-3-112-6-465 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with steroid-responsive, severe aphthous ulceration involving the mouth, hypopharynx, and esophagus have been described in a previous report (1). In these patients, serious morbidity resulted from the pain and dysphagia associated with the ulcers. Since the publication of this report (1), we have seen another six patients who had giant esophageal ulcers as well as colonic ulcers. In one patient, the colonic ulcers resulted in gastrointestinal hemorrhage. Biopsy specimens from the lesions did not show an underlying recognizable virus or fungus, and five patients responded rapidly to high-dose prednisone therapy. We describe some representative patients and summarize their response...References1. Bach M, Valenti A, Howell D, and Smith T. Odynophagia from aphthous ulcers of the pharynx and esophagus in the acquired immunodeficiency syndrome. Ann Intern Med. 1988;109:338-9. LinkGoogle Scholar2. Feder H and Bialecki C. Periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis [Letter]. Pediatr Infect Dis J 1989;8:186-7. MedlineGoogle Scholar3. Youle M, Clarbour J, and Farthing C. Treatment of resistant aphthous ulceration with thalidomide in patients positive for HIV antibody. BMJ. 1989;298:432. CrossrefMedlineGoogle Scholar4. Grinspan D, Blanco G, and Aguero S. Treatment of aphthae with thalidomide. J Am Acad Derm. 1989;20:1060-3. CrossrefMedlineGoogle Scholar5. Read S, Lyons M, Li H, and Zabriskie J. Colchicine inhibits HIV-1 in vitro [Abstract WCO24]. Abstracts for the Vth International Conference on AIDS, Montreal, Canada, June 1989. Google Scholar6. Dretler R and Rausher D. Giant esophageal ulcer healed with steroid therapy in an AIDS patient. Rev Infect Dis. 1989;11:768-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Michael C. Bach, MD; Douglas A. Howell, MD; August J. Valenti, MD; Thomas J. Smith, MD; Dean L. Winslow, MDFrom Maine Medical Center, Portland, Maine; Swedish Medical Center, Seattle, Washington; and Medical Center of Delaware, Wilmington, Delaware. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEsophageal UlcersEsophagitisInfectious EsophagitisEsophagitisHuman Immunodeficiency Virus EsophagitisThalidomide: an emerging drug in oral mucosal lesionsMaladie de BehçetEnfermedad de BehçetAfte, aftosi, malattia di BehçetInfectious EsophagitisAphtes, aphtoses, maladie de BehçetAftas, aftosis, enfermedad de BehçetEsofagites em pacientes com síndrome de imunodeficiência adquirida: estudo histológico e imunoistoquímico"Diversion" Colitis Caused by Clostridium difficile Infection: Report of a CaseFrom symptom to diagnosis: clinical distinctions among various forms of intestinal inflammationRecurrent aphthous ulcers today: a review of the growing knowledgeThe Histopathology of 103 Consecutive Colonoscopy Biopsies From 82 Symptomatic Patients With Acquired Immunodeficiency SyndromeNecrotizing ulcerative stomatitis in human immunodeficiency virus–seropositive individuals: A review of the histopathologic, immunohistochemical, and virologic characteristics of 18 casesReduced number of Langerhans cells in oesophageal mucosa from AIDS patientsIdiopathic esophageal ulceration in acquired immunodeficiency syndrome: successful treatment with misoprostol and viscous lidocainePrevalence and Etiology of Gastroduodenal Ulcer in HIV-Positive Patients: A Comparative Study of 497 Symptomatic Subjects Evaluated by EndoscopyBenign Nonpeptic Esophageal Strictures: Diagnosis and TreatmentEtiology and Outcome of Lower Gastrointestinal Bleeding in Patients With AIDSINTRA-ABDOMINAL MANIFESTATIONS OF AIDSGASTROINTESTINAL PATHOLOGY IN HIV-INFECTED PATIENTSIdiopathic Esophageal Ulcers in a Child with AIDSGastrointestinal Manifestations in Pediatric AidsThalidomide treatment for idiopathic esophageal ulcers in patients with HIVValue of laboratory investigations in clinical suspicion of cytomegalovirus-induced upper gastrointestinal tract ulcerations in HIV-infected patientsTreatment of neutropenic oral ulceration in human immunodeficiency virus infection with G-CSFGastrointestinal Problems in HIVThalidomide-resistant HIV-associated aphthae successfully treated with granulocyte colony-stimulating factorGenital ulcer disease in women infected with human immunodeficiency virusInfectious EsophagitisTreatment of aphthous ulcers in AIDS patientsOral manifestations associated with HIV-related disease as markers for immune suppression and AIDSMajor aphthous ulcers in patients with HIV diseaseDysphagia in systemic diseasePain in human immunodeficiency virus disease: a review13. 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Kaufmann, MDUnusual cause of pharyngeal ulcerations in AIDSThalidomide in hyperalgic pharyngeal ulceration of AIDSCytomegalovirus disease of the gastrointestinal tract in AIDSThe use of drugs in patients with gastrointestinal manifestations of AIDSInflammatory bowel disease coexistent with viral hepatitis and HIV 15 March 1990Volume 112, Issue 6 Page: 465-467 Keywords AIDS Dysphagia Esophagus Gastrointestinal hemorrhage Gastrointestinal tract Lesions Morbidity Mouth Patient advocacy Ulcers ePublished: 1 December 2008 Issue Published: 15 March 1990 PDF downloadLoading ...