Pentamidine-Associated Hypotension and Route of Administration
Authors: CHARLES G. HELMICK
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 September 1985Pentamidine-Associated Hypotension and Route of AdministrationCHARLES G. HELMICK, M.D., JEANETTE K. GREEN, M.D.CHARLES G. HELMICK, M.D., JEANETTE K. GREEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-480_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hypotension is a serious adverse reaction to pentamidine, a drug used to treat Pneumocystis carinii pneumonia, and it has been reported to occur more frequently after intravenous than intramuscular administration (1-4). Thus, intramuscular injection usually is the preferred route of administration. However, a recent report suggests that moderate or severe hypotension occurs more frequently after intramuscular injection (5).The frequency of hypotension by route of administration was determined retrospectively through chart review for 167 (90%) of 184 patients who received pentamidine between 7 June and 11 October 1984 at 15 New York City hospitals. Because of...References1. DAUBNEYHUDSON R. The action of two aromatic diamines on Trypanosoma congolense infections in cattle; with a note on delayed poisoning by 4:4′-diamidino diphenoxy pentane. Ann Trop Med Parasitol. 1941;35:175-86. CrossrefGoogle Scholar2. WIEN R. The pharmacological actions of certain aromatic diamidines possessing trypanocidal activity. Ann Trop Med Parasitol. 1943;37:1-18. CrossrefGoogle Scholar3. ADAMS A. Studies in chemotherapy: XXVI. A case of Indian kalaazar treated with 4:4′-diamidino phenoxypentane. Ann Trop Med Parasitol. 1941;35:53-4. CrossrefGoogle Scholar4. WESTERNPERERASCHULTZ KDM. Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia. Ann Intern Med. 1970;73:695-702. LinkGoogle Scholar5. NAVINFONTAINE TR. Intravenous versus intramuscular administration of pentamidine [Letter]. N Engl J Med. 1984;311:1701-2. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Center for Infectious Diseases Centers for Disease Control Atlanta, GA 30333 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByReview of T-2307, an Investigational Agent That Causes Collapse of Fungal Mitochondrial Membrane PotentialAnthelmintics in DermatologyIn Vitro Antimicrobial Susceptibility Patterns of BlastocystisInvestigation and Presentation of Autonomic Neuropathies in HIV InfectionEffects of Acute Intravenous Administration of Pentamidine, a Typical hERG-Trafficking Inhibitor, on the Cardiac Repolarization Process of Halothane-Anesthetized DogsPharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness.Peripheral Neuropathies Associated with Human Immunodeficiency Virus InfectionAcquired Immunodeficiency SyndromeNeurological Manifestations of HIV InfectionCardiac involvement in aids 1 September 1985Volume 103, Issue 3Page: 480-480KeywordsAdverse reactionsChartsDrug administrationHypotensionIntramuscular injectionsPneumocystis carinii pneumoniaRoutes of administration Issue Published: 1 September 1985 PDF DownloadLoading ...