tbuckley/cabot-search huggingface dataset:
PROTEIN SENSITIVITY IN CHILDREN WITH NEGATIVE CUTANEOUS REACTIONS
Authors: EDWARD SCOTT O'KEEFE
Journal: JAMA (1923)

The percentage of positive protein cutaneous tests in the eczema of infants and younger children has been variously estimated as between 40 and 65 per cent, of the cases.<sup>1</sup>The presumption has been that the remaining negative cases were not due to protein sensitivity. There are, however, a not insignificant number of the remaining cases negative to all proteins used which can clinically be demonstrated to have a protein as the underlying causative factor. Schloss mentions this phenomenon. He reports cases in which there is shown clinically a definite food idiosyncrasy in spite of negative cutaneous protein tests. He states that the ingestion of certain foods, very often cow's milk, results in a gastro-intestinal upset. The type of case I will discuss differs from Schloss' cases in that the reaction to the ingestion of the offending protein is cutaneous, in the form of eczema, rather than gastro-intestinal, as in
Patients and the Habits of House Officers
Authors: Anastassios C. Koumbourlis
Journal: JAMA (1987)

To the Editor.—  In their article, Dunn et al 1 find that house officers' attitudes regarding attire and etiquette are considered inappropriate by patients and they therefore recommend that physicians adopt conservative habits to avoid displeasing a substantial segment of the patient  Although differences in attitudes between physicians and patients may, as the authors point out, adversely affect the relationship that is essential for optimal care, their findings do not justify their recommendation.  As the authors recognize, their findings represent only a segment of the population. Not surprisingly, it is the most conservative one, considering that the majority of the patients were middle-aged or older. Since the presumably inappropriate attitudes may be perceived differently by other segments of the population (children, for example, often perceive the white coat as threatening, while adolescents and teenagers usually feel more comfortable with somebody who dresses like them), it is hard to understand
Antigen-specific T cell redirectors (ATR) for antigen-specific redirection of T cells to tumors
Authors: Christian Schütz, Karlo Perica, Juan Varela, Carl Haupt, Mathias Oelke, Jonathan Schneck
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Immunotherapy is the modulation of a patient's immune system to treat illness. Unfortunately many T cell based attempts have failed due to the fact that existing tumor-specific T cells are mostly anergic or tolerized and ex vivo generated T cells are often already of exhausted
Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide
Authors: M.E. McManaway, A.A. Al-Nasser, B.T. Shiramizu, W.L. Goldschmidts, K. Bhatia, I.T. Magrath, L.M. Neckers, S.L. Loke, R.L. Redner, B.E. Huber
Journal: The Lancet (1990)
State of research: environmental pathways and food chain transfer.
Authors: B E Vaughan
Journal: Environmental Health Perspectives (1984)

Data on the chemistry of biologically active components of petroleum, synthetic fuel oils, certain metal elements and pesticides provide valuable generic information needed for predicting the long-term fate of buried waste constituents and their likelihood of entering food chains. Components of such complex mixtures partition between solid and solution phases, influencing their mobility, volatility and susceptibility to microbial transformation. Estimating health hazards from indirect exposures to organic chemicals involves an ecosystem's approach to understanding the unique behavior of complex mixtures. Metabolism by microbial organisms fundamentally alters these complex mixtures as they move through food chains. Pathway modeling of organic chemicals must consider the nature and magnitude of food chain transfers to predict biological risk where metabolites may become more toxic than the parent compound. To obtain predictions, major areas are identified where data acquisition is essential to extend our radiological modeling experience to the field of organic chemical contamination.
lndium-111 Leukocyte Localization in Infected Prosthetic Graft
Authors: GARY L. PURNELL, CRAIG W. WALKER, JANICE W. ALLISON, GLENN V. DALRYMPLE
Journal: Clinical Nuclear Medicine (1990)

Infective endocarditis can be difficult to prove, even in the face of strong clinical suspicion. A case in which standard methods of diagnosis failed to demonstrate endocarditis in a patient with recurrent Staphylococcus aureus bacteremia and porcine aortic valve is reported. An ln-111 labeled leukocyte SPECT study demonstrated uptake in the aortic root and leaflets, and autopsy demonstrated vegetations on the leaflets, ln-111 may prove useful in demonstrating endocarditis in patients with prosthetic valve infection.
The architecture is not exactly parallel: Some modules are more equal than others
Authors: Boris B. Velichkovsky, Andrej A. Kibrik, Boris M. Velichkovsky
Journal: Behavioral and Brain Sciences (2003)

Despite its computational elegancy, Jackendoff's proposal to reconcile competing approaches by postulating a parallel architecture for phonological, syntactic, and semantic modules is disappointing. We argue that it is a pragmatic version of the leading module which Jackendoff would probably prefer, but which he does not explicitly acknowledge. This internal conflict leads to several shortcomings and even distortions of information presented in the book.
ISCHEMIC OR NON-ISCHEMIC MYOCARDIAL SCAR QUANTIFICATION PREDICTS FUTURE ARRHYTHMIC EVENTS IN CANDIDATES FOR PRIMARY PREVENTION ICD
Authors: Peng Gao, Raymond Yee, Ellie Hogg, John Stirrat, David Scholl, Lorne Gula, Andrew D. Krahn, Allan Skanes, Peter Leong-Sit, George Klein, James A. White
Journal: Journal of the American College of Cardiology (2011)
Double dose oseltamivir for severe influenza--does it help?
Authors: I. G. Barr, A. C. Hurt
Journal: BMJ (2013)

No, we need to seek new and better treatment options

While it is relatively uncommon for the annually circulating seasonal influenza viruses to lead to severe influenza in humans, for certain influenza viruses, such as A(H5N1) and A(H7N9), severe influenza is a common outcome. A(H5N1) (the so called “bird flu”) has since 2003 led to 628 cases and 374 deaths,1 with the avian A(H7N9) influenza virus in China in 2013 having 131 cases and 32 deaths.2 It is not yet clear how best to treat severe influenza and whether the duration of illness can be shortened and survival improved with appropriate antiviral drug treatment. A linked paper from the South East Asian Infectious Disease Clinical Research Network (SEAICRN) (doi:10.1136/bmj.f3039) describes the effectiveness of treating adults and children (aged ≥4) with severe influenza (seasonal, pandemic, and bird flu) with either the regular dose or a double dose of the neuraminidase inhibitor oseltamivir (Tamiflu, the most commonly available anti-influenza drug).

Why is this relatively simple trial important? We have only a limited choice of drugs to treat severe influenza: the adamantanes (rimantadine and amantadine) and the neuraminidase inhibitors (oseltamivir, zanamivir, laninamivir, peramivir), although occasionally other drugs, such as ribavirin, have been used. Unfortunately, with the exception of some A(H5N1) viruses, most influenza viruses currently infecting people (including the avian A(H7N9) virus) are resistant to the adamantanes.3 This leaves the neuraminidase inhibitors, which generally have a modest therapeutic effect on non-complicated influenza, reducing symptoms by only …
Extracellular Volume Imaging and Quantitative T2 Mapping for the Diagnosis of Mitochondrial Cardiomyopathy
Authors: Kyoung Hwa Lee, Heae Surng Park, Chul Hwan Park, Ki-Hyun Kim, Hyemoon Chung, Tae Hoon Kim, Se-Joong Rim, Eui-Young Choi
Journal: Circulation (2014)
Unexplained Fever in Burn Patients due to Cytomegalovirus Infection
Authors: George S. Deepe
Journal: JAMA (1982)

Unexplained fever in burn patients is a common clinical problem. Four cases of cytomegalovirus (CMV) infection in burn patients with unexplained fevers are described. Infection occurred at least one month after hospitalization and was characterized by prolonged fever and lymphocytosis without atypical lymphocytes. Recognition of CMV infection is important in the management of burn patients since it may prevent the administration of potentially toxic antibiotics and the pursuit of unnecessary diagnostic tests. (<i>JAMA</i>1982;248:2299-2301)
The Winter Branch
Authors: Floyd Skloot
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterization of a Putative Ovarian Oncogene, Elongation Factor 1α, Isolated by Panning a Synthetic Phage Display Single-Chain Variable Fragment Library with Cultured Human Ovarian Cancer Cells
Authors: Sameer Sharma, Jonathan Tammela, Xinhui Wang, Hilal Arnouk, Deborah Driscoll, Paulette Mhawech-Fauceglia, Shashikant Lele, A. Latif Kazim, Kunle Odunsi
Journal: Clinical Cancer Research (2007)

Abstract Purpose: In an effort to identify cell surface targets and single short-chain antibody (scFv) for ovarian cancer therapy, we used a phage display approach to isolate an antibody with high reactivity against ovarian cancer. Experimental Design: A phage scFv library was subjected to panning against human SK-OV-3 ovarian cancer cells. A clone with high reactivity was selected and tested in immunoperoxidase staining on a panel of normal tissues and ovarian carcinoma. Using immunoprecipitation, a differentially expressed band was analyzed by mass spectrometry. The antigen subclass was characterized with reverse transcription-PCR on cDNA library of normal tissues, and 91 ovarian cancer specimens, and correlated with clinicohistopathologic characteristics. Results: Ninety-six individual scFv clones were screened in ELISA following panning. scFv F7 revealed high reactivity with ovarian cancer cell lines and showed intense staining of 15 fresh ovarian cancer specimens and no staining of a panel of normal tissues. A 40-kDa protein was identified to be translation elongation factor 1α1 (EEF1A1; P &amp;lt; 0.05). The expression of EEF1A2, a highly homologous and functionally similar oncogene, was found to be restricted only to the normal tissues of the heart, brain, and skeletal muscle. Aberrant EEF1A2 mRNA expression was found in 21 of 91 (23%) of ovarian cancer specimens and significantly correlated with increased likelihood of recurrence (P = 0.021). Conclusions: scFv F7 may represent an ovarian cancer–specific antibody against translation EEF1A family of translational factors. We propose that EEF1A2 may be a useful target for therapy of human ovarian cancer.
Dual effects of 17 -oestradiol on interleukin 1 -induced proteoglycan degradation in chondrocytes
Authors: P Richette
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objective:</b> To determine whether 17β-oestradiol (E2) modulates interleukin (IL) 1β-induced proteoglycan degradation in chondrocytes, and to analyse the part played by metalloproteinases (MMPs) in this process. <b>Methods:</b> Primary cultured rabbit articular chondrocytes were prepared and treated with 10 ng/ml IL1β combined or not with 0.1–10 nM E2. Neosynthesised proteoglycans (PGs) were evaluated after incorporation of [<sup>35</sup>SO<sub>4</sub>]sulphate and further analysed after chromatography on a Sepharose 2B column. Chondrocyte mRNA levels of aggrecan, MMP-1, -3, -13, and tissue inhibitor of metalloproteinase-1 (TIMP-1) were studied by northern blot. MMP-1 activity was measured by zymography. MMP-1 gene transcription was studied by transient transfection of chondrocytes with an MMP-1-luciferase construct. <b>Results:</b> E2 modulated the IL1β-induced total sulphated PGs in rabbit articular chondrocytes, which decreased as the E2 concentration was increased. At a low concentration (0.1 nmol/l) E2 counteracts the IL1β-induced decrease in sulphated PG, while at high concentration (10 nmol/l) E2 enhances the IL1β effects. A biphasic E2 effect was also observed on IL1β-induced disaggregation of PG, 53–58 kDa gelatinolytic activity, and MMP-1, -3, and -13 mRNA levels. In contrast, E2 did not modify the level of aggrecan mRNA and had no effect on TIMP-1 mRNA expression. Finally, simultaneous addition of IL1β and E2 (0.1–10 nmol/l) did not modify IL1β-induced MMP-1-luciferase activity, suggesting that E2 effects probably occur at the post-transcriptional level of MMP gene expression. <b>Conclusion:</b> Oestrogen concentration may have an inverse effect on IL1β stimulated proteoglycan degradation and MMP production by chondrocytes.
Elevation of Ambulatory Systolic Blood Pressure in Hypertensive Smokers
Authors: Samuel J. Mann
Journal: JAMA (1991)

Although smoking raises blood pressure, the office blood pressure measurements of smokers are the same as, or lower than, those of nonsmokers. To resolve this paradox, we compared the office and 24-hour ambulatory blood pressures of 59 untreated hypertensive smokers with 118 nonsmoking hypertensives matched for age, sex, and race. The office blood pressures of the smoking and nonsmoking groups were 141/93 and 142/93 mm Hg, respectively. The awake ambulatory systolic blood pressure was significantly higher in the smokers (145 vs 140 mm Hg). This difference was greater among patients over the age of 50 years (153 vs 142 mmHg), and absent among patients under 50 years (140 vs 139 mm Hg). Blood pressures during sleep did not differ between the two groups (121/76 vs 123/77 mm Hg). We conclude that, among white hypertensives above the age of 50 years, smokers maintain a higher daytime ambulatory systolic blood pressure than nonsmokers even though blood pressure measured in the office is similar.
Strategy launched to boost research in the NHS in England
Authors: Susan Mayor
Journal: BMJ (2006)

The UK government has introduced a new research strategy, designed to make it easier to carry out research in the NHS in England, with a series of proposals published this week. The proposals aim to establish the NHS as an internationally recognised centre of research excellence, with a commitment to spend more than £650m ($1150m; €950m) a year on high quality patient based research and development.

“The aim is to enable the NHS to become an organisation that supports outstanding individuals (both leaders and collaborators), working in world-class facilities (both NHS and university), conducting leading-edge research,” the document says.

The strategy's recommendations are designed to solve the problems faced by researchers working in the NHS, including bureaucratic blocks to clinical research, allocation of research funding on a historical basis, barriers to the collection …
A young female with fatigue and dyspnoea
Authors: B. Tobler, D. Schneiter, A.B. Barghorn, C. Steurer-Stey
Journal: European Respiratory Journal (2004)

Case historyA 25-yr-old female was admitted to hospital due to fatigue and dyspnoea for a duration of 3 months.Difficulty in breathing occurred during physical activity and in stressful situations, but also sometimes during bed rest, and was associated with the feeling of palpitations.The patient smoked 30 cigarettes?day -1 (total 8 pack-yrs) and took no medication.The patient9s personal and family history was uneventful.There was no recent history of travelling.She worked as a clerk and noticed no change in symptoms at work or over the weekends.The patient was overweight (body mass index 31.5kg?m -2 ) and had a normal body temperature on clinical examination.Her blood pressure was 120/80 mmHg, heart rate 76 beats?min -1 and respiratory rate 20 breaths?min -1 .No crackles were heard during auscultation.The blood tests showed no abnormalities, specifically no anaemia nor inflammatory signs.A chest radiograph and ECG were performed, and showed normal results.Pulmonary function tests demonstrated normal static
Hospital medical staffing in Scotland: the Shaw report
Authors: A. Vallance-Owen
Journal: BMJ (1988)

In  wake of  publication of Hospital Medical Staffing: Achieving a Balance: Plan for Action1 a different but for Scotland equally influential report on medical manpower has been published. Officially titled Staffing  Service?the Next Decade,  report is colloquially known as  Shaw review after  chairman of  review's steering group, Dr Gavin Shaw, a consultant physician.2 The review is different from Plan for Action because rather than providing a bird's eye view of medical staffing, as many other centrally conceived reports have previously done, it has been built from within  specialties and hospitals of Scotland. It goes much further than Plan for Action in that it makes specific recom? mendations for changes in medical staffing on a hospital by hospital basis to be achieved over  next five to ten years. The main points from  review are in  box, and  table summarises  projected staffing changes for  next decade. In 1983  profession, together with  chief administrative medical officers of  Scottish health boards and  Scottish Home and Health Department (SHHD), set up a working party on  medical staffing structure. This endorsed a comprehensive review with  aim of correcting  imbalance between  number of doctors in  training and consultant grades. There was strong feeling within  profession that if it did not take steps to rectify  imbalance others might do so. It was agreed that  steering group for  review would be set up jointly by  SHHD and  Scottish Joint Consultants Committee. The group had no formal remit apart from  working party's report, which gave certain guidelines, one of  main ones being that the service would be consultant led with  expectation that in many specialties an increasing proportion of patient care will be provided by consultants. There were two principal objectives: firstly, that patient care should be maintained and improved; and, secondly, to realign and restructure medical staffing so that doctors had acceptable career prospects and workloads, without which patient care would inevitably suffer. Seven specialty subgroups were set up with a balance of academic and National Health Service representatives, each group also containing two members from  training grades. Generally all  main teaching and general hospitals in Scotland were visited in  wake of a questionnaire sent out in advance?180 visits were made in all. The chairman of each of  specialty subgroups checked  main facts in each specialty report; figures were also verified by checking with those held by  information services division of  Scottish Office. The detailed recommendations for staffing are elaborated in volume II of  review, where  specialty reports are published. Volume I carries a statement of  main principles underlying  review together with a discussion of roles of  various grades; it also contains a summary of each of  specialty reports.
Book Review Practical Pediatric Oncology Edited by Giulio J. D'Angio, Davendralingam Sinniah, Anna T. Meadows, Audrey E. Evans, and Jon Pritchard. 417 pp. New York, Wiley-Liss, 1992. $69.95. 0-471-58835-0
Authors: Robert L. Baehner
Journal: New England Journal of Medicine (1993)
Stress and the Common Cold
Authors: Motton N. Swartz
Journal: New England Journal of Medicine (1991)

In biomedical terms, "stress" refers to any adverse physical, mental, or emotional stimulus (stressor) that upsets the organism's homeostasis, or to the aggregate of biologic responses to such stimuli. At the physiologic level, stress has been the subject of study going back to Walter B. Cannon's description of the "fight or flight" response involving actions of the sympathetic nervous system and the adrenal medulla.1 Subsequently, Hans Selye introduced the concept that highly varied Stressors (physical agents, toxic chemicals, or psychological factors) might elicit similar integrated responses. This neuroendocrine response to stress was described as including stimulation of the pituitary-adrenocortical axis, . . .
Bioterrorism and compulsory vaccination
Authors: Tom Jefferson
Journal: BMJ (2004)

be aimed for, not something that must be achieved at all costs.Individual patients must be involved in decisions about their care, and this requires effective communication on the subject of risks, benefits, and side effects.This is difficult, but it can be facilitated by aids and charts expressing risk in absolute terms. 11By involving patients in their own care, control of a disease can be improved. 12Appropriate management of blood pressure should therefore be guided by an informed dialogue between patients and doctors and not by blind pursuit of blood pressure targets.