tbuckley/cabot-search huggingface dataset:
John Stehlin: holistic oncology and a nude mouse
Authors: Gail McBride
Journal: JAMA (1979)

In 1967, John S. Stehlin, Jr, MD, left the M. D. Anderson Hospital and Tumor Institute in Houston, where he had been on the fulltime surgical staff for ten years, and went out on his own. His dream was not only to treat patients with cancer more "creatively" but to have a research laboratory in which only human cancers would be studied. Constant feedback would occur between the laborary and the bedside. Fulfillment of that dream seemed far away for the 44-year-old surgical oncologist with only $6,700 in his pocket. Yet Stehlin, with a little help from colleagues, friends, and grateful former patients, seems to have made it come true. Today, the Stehlin Foundation for Cancer Research in Houston, with 25 researchers, has an annual budget of $1 million. There, Stehlin and his young partners, surgical oncologists Peter D. de Ipolyi, MD, and Pierre J. Greeff, MD, are in the
Lower Plasma Dehydroepiandrosterone Concentration in the Long Term after Severe Accidental Injury
Authors: Misari Oe, Ulrich Schnyder, Sonja Schumacher, Christoph Mueller-Pfeiffer, Frank H. Wilhelm, Nilüfer Kalebasi, Daniel Roos, Martin Hersberger, Chantal Martin-Soelch
Journal: Psychotherapy and Psychosomatics (2012)
Metabolic evidence of viable myocardium in regions with reduced wall thickness and absent wall thickening in patients with chronic ischemic left ventricular dysfunction
Authors: Pasquale Perrone-Filardi, Stephen L. Bacharach, Vasken Dilsizian, Simone Maurea, Jose A. Marin Neto, James A. Arrighi, Joseph A. Frank, Robert O. Bonow
Journal: Journal of the American College of Cardiology (1992)
Importance of the Primer for Otolaryngology Residents and Students
Authors: Jack L. Gluckman
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anesthetization During Sleep.
Authors: W. C. Welburn
Journal: JAMA (1901)

Nashville Tenn., May 20, 1901. <h3>To the Editor:</h3> —If the anesthetization of children during sleep is of medicolegal interest I can add one case to the three reported by Dr. Paugh inThe Journalof May 18. A boy of 18 or 20 months was brought to the clinic of Dr. J. A. Bodine, of the New York Polyclinic for circumcision. The child was found to be asleep in the mother's arms and the gradual administration of chloroform was begun without disturbing its slumbers. Complete surgical anesthesia was finally produced without any sign of irritation or symptom of awakening. Recovery from anesthesia was rapid, the child being in much better humor for having been spared the fright and shock of forced anesthesia. The procedure is uncommon, but by no means impossible or even difficult of achievement.
Beneficial Impact of Preconditioning During PTCA on Creatine Kinase Release
Authors: Warren K. Laskey
Journal: Circulation (1999)

Background —Previous studies in humans have indicated that there is less ischemic dysfunction during PTCA when ischemic preconditioning is elicited. However, the clinical relevance of these observations remains unclear. The present study design tests the hypothesis that PTCA performed to elicit the preconditioning response would result in less myocardial necrosis as assessed by postprocedure creatine kinase (CK) levels Methods and Results —Patients (n=150) undergoing PTCA for unstable ischemic syndromes were randomly assigned to receive a previously validated approach to PTCA-mediated preconditioning (PC) or an unrestricted approach to balloon angioplasty (UC). CK levels were determined at 8, 12, and, if necessary, 24 hours. Clinical success rates were equivalent for the 2 groups. However, the frequency of any CK elevation was significantly higher in the UC group (25%) than in the PC group (7.1%) ( P &lt;0.005). Multivariable analysis confirmed a significant effect of preconditioning on CK release. Conclusions —A standardized protocol to elicit preconditioning during PTCA results in a significant reduction in the rate of CK elevation in a high-risk population. These observations support the clinical relevance of ischemic preconditioning in humans.
Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells
Authors: Duohui Jing, Vivek A. Bhadri, Dominik Beck, Julie A. I. Thoms, Nurul A. Yakob, Jason W. H. Wong, Kathy Knezevic, John E. Pimanda, Richard B. Lock
Journal: Blood (2014)
Mortality associated with foodborne bacterial gastrointestinal infections: Authors' reply
Authors: M. Helms
Journal: BMJ (2003)

EDITOR—Our study was unique because it included patients with infectious gastro-enteritis, by and large people who sought care from their family doctor and had no severe underlying illness. The concerns that O'Brien and Feldman raise about bias introduced by case selection is likely to be less relevant in Denmark as the Danish counties reimburse laboratory costs, and for epidemiological reasons doctors often request stool specimens. Our study was the first to determine mortality while adjusting for background mortality. This was pivotal because gastrointestinal infections often affect elderly people. Furthermore, we adjusted for comorbidity by using data from the national discharge registry. We applied the principles described by Charlson et al,1 but calculated new …
N-Terminal pro brain natriuretic peptide (NT-proBNP) predicts left ventricular function and mortality in hemodialysis patients but not cardiac death: a two-year outcome study
Authors: Joseph P. Longhitano, William L. Henrich, Paul D. Light, Eric Tiblier, Heidi Sperger, Mathew M. Smiley, John Badalamenti, Juergen Trawinski, Christopher R. deFilippi
Journal: Journal of the American College of Cardiology (2002)
Duodenogastric Reflux Demonstrated by Cholescintigraphy in Peptic Ulcer Disease and Chronic Gastritis
Authors: G X WANG, W J SHIH, P L TANG, X H DIAN, W J ZHANG
Journal: Clinical Nuclear Medicine (1994)

Duodenogastric (D-G) reflux is commonly associated with peptic ulcer disease and chronic gastritis. To determine D-G reflux in association with each disease entity, we studied 43 chronic gastritis patients and 21 peptic ulcer patients with cholescintigraphy. Scoring (0 to 3+) was judged by the amount of Tc-99m diethylacetanitanilido-IDA (EHIDA) in the stomach. In the chronic gastritis group, 5, 16, 10, and 12 patients scored 3+, 2+, 1+, and 0, respectively. In the peptic ulcer disease group 6, 2, and 13 patients scored 2+, 1+, and 0, respectively. Thirty-nine of the 64 patients (60.9%) were positive for D-G reflux. D-G reflux occurred in 31 of 43 (72.09%) of chronic gastritis patients and in 8 of 21 (38.1%) patients with peptic ulcer disease. D-G reflux was significantly higher in the chronic gastritis group (P = 0.0009). Chronic gastritis patients were more likely to have more marked D-G reflux than peptic ulcer disease (P = 0.048). The authors conclude that cholescintigraphy is noninvasive and objectively demonstrates D-G reflux in chronic gastritis and peptic ulcer disease and that chronic gastritis is more closely associated with D-G reflux than peptic ulcer disease.
Half full or half empty VATS?
Authors: Peter McCulloch
Journal: BMJ (2004)

Data were voluntarily provided by members of the Society of Cardiothoracic Surgeons of Great Britain and Ireland.Tom Treasure is responsible to the society for the collection and collation of these data and has a mandate from the society's annual general meeting of its members to disseminate information based on the data.Contributors: AS, TT, and JvdM were responsible for study concept and design.TT and AS were responsible for acquisition of the data and administrative, technical, or material support.AS and JL analysed the data and provided statistical expertise.
From reflex to planning: Multimodal versatile complex systems in biorobotics
Authors: Jean-Paul Banquet, Philippe Gaussier, Mathias Quoy, Arnaud Revel
Journal: Behavioral and Brain Sciences (2001)

As models of living beings acting in a real world biorobots undergo an accelerated “philogenic” complexification. The first efficient robots performed simple animal behaviours (e.g., those of ants, crickets) and later on isolated elementary behaviours of complex beings. The increasing complexity of the tasks robots are dedicated to is matched by an increasing complexity and versatility of the architectures now supporting conditioning or even elementary planning.
Background to Migraine
Authors: James F. Toole
Journal: JAMA (1968)

At times one reads a book crammed full of provocative ideas about a subject which, in the recent past, has been rather unproductive of new material.<i>Background to Migraine</i>, which contains the edited transcript of the First Migraine Symposium held at the National Hospital, Queen Square, London, is such a book. Even the foreword by the British Minister of Health is worth reading—short, to the point, with a bit of dialectic, and a quote from Ralph Waldo Emerson. R. Blend and James W. D. Bull present their experience with the radiological investigation of patients with migraine. M. D. O'Brien, N. Veall, and H. R. A. Townsend discuss measurements of cerebral blood flow and electroencephalography in migrainous patients, and the literature on vasospasm in migraine is summarized by Lindsay Simon. Polypeptides, amine changes, and other biochemical determinations relating to migraine are covered concisely by J. M. Robson, C. A. Keele, G.
192. RGD- Functionalised Liposome for Tumour Targeting
Authors: Jianmeizi (May) Chen, Ayesha Ahmad, Andrew D. Miller, Michael Keller, Eric Perouzel, Michael R. Jorgensen
Journal: Molecular Therapy (2006)

Liposomal vectors have been widely studied for targeted gene and drug delivery to tumour cells. In vivo these systems encounter problems with serum stability, tumour localisation, cell internalisation and endosomal escape. Modification or shielding of the liposome surface helps to inhibit non-specific interaction with blood components and enables an extended circulation of the vectors after systemic administration. This is achieved with a hydrophilic polymer of which polyethylene glycol (PEG) has been found to be best. Targeting cell-surface receptors is an attractive concept to achieve specific binding and internalisation of the liposome. To this end, cell-binding ligands are displayed from the surface of the liposome. The common denominator for these ligands is that their cell receptor targets are over-expressed in tumours.
816. RNAi Applications for Respiratory Epithelia: Delivery and Efficacy
Authors: Anthony J. Fischer, Christine L. Wohlford-Lenane, Patrick L. Sinn, Hong Peng Jia, Steven M. Varga, Beverly L. Davidson, Paul B. McCray
Journal: Molecular Therapy (2005)

The airway epithelium is a common site of disease pathogenesis, including viral infections and primary diseases associated with inflammation. The delivery of RNAi to respiratory epithelia offers an approach to inhibit replication of RNA viruses and modify host responses to infection. To this end, we are using respiratory syncytial virus (RSV) as a model disease target. RSV is a major cause of respiratory disease in infants and immunocompromised adults. There is no approved vaccine for RSV, and medical treatment is supportive. The primary site of RSV replication is in the respiratory epithelium. As a proof of principle for RNAi delivery to the conducting airways of mice, we used gel-formulated adenoviral vectors to deliver short hairpin RNAs (shRNAs) against GFP or an irrelevant control to respiratory epithelia of GFP-transgenic mice. Vector transduced cells were visualized by expression of a reporter gene (dsRed or beta-galactosidase) to localize cells with putative RNAi activity. This approach achieved efficient transduction of the conducting airway epithelium. The efficiency of RNAi against GFP is measured by reduction of GFP in transduced cells. In a complementary approach, we are evaluating uptake of Cy3 labeled siRNA oligos in polarized human airway epithelial (HAE) cell culture and in mouse models. To inhibit RSV expression in vitro and in vivo, shRNAs were designed against the viral nucleocapsid (N) and large polymerase (L) genes of the RSV A2 strain and cloned into an expression vector behind a mU6 promoter. A misdirected control shRNA was produced by the same method to control for off-target effects of shRNA. Short hairpin expression vectors were screened for RNAi activity against renilla luciferase-viral gene fusions in co-transfection experiments, and functional constructs were identified. Subsequently, antiviral activity of effective shRNAs was measured in an in vitro infection model by reduction of viral RNA (Real Time-PCR) and viral protein (western blot). We will present our progress in these studies.
Pendulum politics of abortion
Authors: J. Warden
Journal: BMJ (1988)

The abortion debate before the UK Parliament is more polarized during the current session than has ever been the case.  At the one extreme is the Alton Abortion Bill that would reduce the pregnancy termination limit from 28 weeks to 18 weeks.  At the other extreme is a recommendation contained in the final report of the House of Lords Select Committee on the Infant Life Act of 1929 that the 28 week restriction on abortion should be lifted altogether.  The House of Lords report argues that in many cases abortions must be permitted later than 28 weeks to protect the interests of mothers who are found to be carrying fetuses with chromosomal abnormalities.  Decision making in such cases should be left to the ethical integrity and judgment of the medical profession rather than legislated.  The House of Lords report is considered to have posed a major challenge to the weakest part of the Alton Bill--what to do about late therapeutic abortions--and may precipitate its defeat.
Lung Transplantation in a Patient with Fibrosing Alveolitis
Authors: P. Hugh-Jones, A. M. Macarthur, P. A. Cullum, S. A. Mason, W. A. Crosbie, D. C. S. Hutchison, M. C. Winterton, A. P. Smith, B. Mason, L. A. Smith
Journal: BMJ (1971)

The transplantation of the right lung into a man aged 40 who was suffering from cryptogenic fibrosing alveolitis is described. Before transplantation he had been dependent on oxygen, even at rest, for 24 hours a day for almost two years. The donor was a boy of 16 years who had had a fatal cerebral haemorrhage. The transplanted lung functioned perfectly from the time of operation until the patient9s sudden death two months later from an overwhelming haemoptysis apparently from a small peribronchial abscess rupturing into the pulmonary artery. By the third postoperative week the patient had been able to walk unaided and without distress outdoors. The problem of differentiating infection from incipient rejection is discussed. We conclude that clinically successful lung transplantation can be achieved, but only if the problems of lung function, infection, and immunosuppression can all be overcome.
Sigmoid motility in diverticular disease and the irritable bowel syndrome.
Authors: I F Trotman, J J Misiewicz
Journal: Gut (1988)

Intraluminal pressures were measured with four open ended, water perfused tubes in the fasting state and after a standard liquid meal (400 KCal, 375 ml, protein 15 g, carbohydrate 55 g, lipid 13.4 g) in six patients with sigmoid diverticular disease, 20 with the irritable bowel syndrome and in 13 controls. The pressure sensors were positioned in the true sigmoid colon at colonoscopy at 25, 35, 45, and 55 cm from the anus. Colonic pressures were significantly higher in diverticular disease than in controls before (p less than 0.02) and after the meal (p less than 0.002), some pressure amplitudes exceeding 300 cm H2O. Patients with the irritable bowel syndrome had lower (p less than 0.05) pressures than controls before the meal. Postprandial sigmoid pressures were within the mean +/- 2 SD of controls in 10, above in two and below in eight patients with the irritable bowel. Hypercontractility of the sigmoid colon in the irritable bowel syndrome was not confirmed under the conditions of this study. The association between sigmoid diverticulosis and high intraluminal pressures is confirmed.
Preventing Disability
Authors: John C. Beck
Journal: JAMA (1996)

Health and social care services required by older persons in this country will be a growing burden and a major societal concern for much of the next century.<sup>1</sup>The long-accepted theories of Gompertz—that mortality rates increase at predictable trajectories—have been challenged because age trajectories of mortality do not follow predictable curves.<sup>2</sup>In fact, in humans, mortality rates decelerate with age. Projections from the US Bureau of the Census have not taken this and other factors into account, however, and the US population of older persons continues to be dramatically underestimated.<sup>3</sup>Thus, the 1990 projection of the number of older people who will be living in the United States in the year 2000 is 34.9 million,<sup>4</sup>while Manton<sup>5</sup>predicts 40.3 million, of whom a substantial proportion will be older than 85 years of age. See also p 1725. Projections of the numbers of disabled elderly in
Growth Hormone Replacement Therapy
Authors: Arlan L. Rosenbloom
Journal: JAMA (1966)

Seven children with anterior hypopituitarism and two children with possible isolated growth-hormone deficiency have been treated with injections of human pituitary growth hormone (HGH) for periods of three months to 3 1/2 years. Administration of HGH was planned to demonstrate the minimal dosage and the maximal interval between injections which are efficacious in growth promotion. Weekly injections of 2.5 to 5 mg of HGH usually were effective in achieving normal or accelerated growth velocity for maturational age. Daily injections of one seventh the weekly dose were not effective, nor were single monthly injections of four times the weekly dose. In one patient, biweekly injections of 10 mg were as effective as weekly injections of 5 mg. Diminishing responsiveness with increasing duration of treatment was observed.
FGF-23 in patients with end-stage renal disease on hemodialysis
Authors: Yasuo Imanishi, Masaaki Inaba, Kiyoshi Nakatsuka, Kyoko Nagasue, Senji Okuno, Asami Yoshihara, Masakazu Miura, Akimitsu Miyauchi, Keisuke Kobayashi, Takami Miki, Tetsuo Shoji, Eiji Ishimura, Yoshiki Nishizawa
Journal: Kidney International (2004)
Effect of d-tryptophan-6-luteinizing hormone-releasing hormone on the tumoral growth and plasma sex steroid levels in cirrhotic patients with hepatocellular carcinoma
Authors: Jérôme Guéchot, Nicolas Peigney, François Ballet, Michel Vaubourdolle, Jacqueline Giboudeau, Raoul Poupon
Journal: Hepatology (1989)

Certain evidence suggests androgen dependence of hepatocellular carcinoma in cirrhotic patients. Consequently, it was postulated that antiandrogen therapy might be effective in the treatment of hepatocellular carcinoma. D-Tryptophan-6-luteinizing hormone-releasing hormone is a potent agonist analog of luteinizing hormone-releasing hormone which, when chronically administered, inhibits the pituitary gonadal axis and testicular androgen secretion in man. We studied the effects of D-tryptophan-6-luteinizing hormone-releasing hormone on tumoral growth in 17 male cirrhotic patients with hepatocellular carcinoma. After 3 to 6 months of therapy, no tumoral response was observed. Furthermore, measurements of plasma levels of testosterone, dihydrotestosterone, androstenedione, estradiol, estrone and sex hormone-binding globulin were performed before and 3 months after initiation of the antiandrogenic treatment. Before treatment, hypoandrogenism and hyperestrogenism were present; D-tryptophan-6-luteinizing hormone-releasing hormone induced a fall in plasma testosterone and dihydrotestosterone levels. Only a moderate decrease in estradiol and no modification of plasma estrone and sex hormone-binding globulin were found, indicating that the hyperestrogenemia of cirrhotic patients could be attributed to an increase in peripheral aromatization of androgens of adrenal origin. The inability of D-tryptophan-6-luteinizing hormone-releasing hormone to reduce the growth of hepatocellular carcinoma is not totally in disagreement with the concept of androgen dependence of hepatocellular carcinoma since D-tryptophan-6-luteinizing hormone-releasing hormone does not inhibit the production of androgens of adrenal origin.
Abnormal Vocal Cord Function in Difficult-to-Treat Asthma
Authors: Kathy Low, Kenneth K. Lau, Peter Holmes, Marcus Crossett, Neil Vallance, Debbie Phyland, Kais Hamza, Garun Hamilton, Philip G. Bardin
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Upper airway dysfunction may complicate asthma but has been largely ignored as an etiological factor. Diagnosis using endoscopic evaluation of vocal cord function is difficult to quantify, with limited clinical application.A novel imaging technique, dynamic 320-slice computerized tomography (CT), was used to examine laryngeal behavior in healthy individuals and individuals with asthma.Vocal cord movement was imaged using 320-slice CT larynx. Healthy volunteers were studied to develop and validate an analysis algorithm for quantification of normal vocal cord function. Further studies were then conducted in 46 patients with difficult-to-treat asthma.Vocal cord movement was quantified over the breathing cycle by CT using the ratio of vocal cord diameter to tracheal diameter. Normal limits were calculated, validated, and applied to evaluate difficult-to-treat asthma. Vocal cord movement was abnormal with excessive narrowing in 23 of 46 (50%) patients with asthma and severe in 9 (19%) patients (abnormal > 50% of inspiration or expiration time). Imaging also revealed that laryngeal dysfunction characterized the movement abnormality rather than isolated vocal cord dysfunction.Noninvasive quantification of laryngeal movement was achieved using CT larynx. Significant numbers of patients with difficult-to-treat asthma had excessive narrowing of the vocal cords. This new approach has identified frequent upper airway dysfunction in asthma with potential implications for disease control and treatment.