Salt, Natriuretic Hormone, and Hypertension
Authors: VARDAMAN M. BUCKALEW
Journal: Annals of Internal Medicine (1981)

Editorials1 October 1981Salt, Natriuretic Hormone, and HypertensionVARDAMAN M. BUCKALEW JR., M.D.VARDAMAN M. BUCKALEW JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-4-511 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNew support for an old theory on the link between salt ingestion and hypertension is rapidly accumulating. In the early 1960s, Dahl and coworkers (1) at Brookhaven Laboratories reported development of two strains of rats in which susceptibility to hypertension was genetically determined. Rats of the "sensitive" (or S) strain ingesting a high-salt diet developed hypertension, whereas in the "resistant" (or R) strain, the same high-salt diet had no effect on blood pressure. Most importantly, a subsequent study (2) showed that susceptibility to salt-induced hypertension could be transferred from the S to the R rat through a parabiotic connection. This...References1. DAHLHEINETASSINARI LML. Effects of chronic salt ingestion: evidence that genetic factors play an important role in susceptibility to experimental hypertension. J Exp Med. 1962;115:1173-90. CrossrefMedlineGoogle Scholar2. DAHLKNUDSENIWAI LKJ. Humoral transmission of hypertension: evidence from parabiosis. Circ Res. 1969;24-25(Suppl. I):I-21-33. Google Scholar3. DEWARDENER H. Natriuretic hormone. Clin Sci Mol Med. 1977;53:1-8. MedlineGoogle Scholar4. HADDYOVERBECK FH. The role of humoral agents in volume expanded hypertension. Life Sci. 1976;19:935-48. CrossrefMedlineGoogle Scholar5. HADDYPAMNANICLOUGH FMD. Humoral factors and the sodium-potassium pump in volume expanded hypertension. Life Sci. 1979;24:2105-18. CrossrefMedlineGoogle Scholar6. BLAUSTEIN M. Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. Am J Physiol. 1977;232:C165-73. CrossrefMedlineGoogle Scholar7. GRUBERWHITAKERBUCKALEW KJV. Endogenous digitalis-like substance in plasma of volume-expanded dogs. Nature. 1980;287:743-5. CrossrefMedlineGoogle Scholar8. PLUNKETTGRUBERHUTCHINSBUCKALEW WKPV. Vascular reactivity is increased by factors in plasma of volume-expanded dogs. Clin Res. 1980;28:827A. Abstract. Google Scholar9. GRUBERWHITAKERRUDELBULLOCKBUCKALEW KJLBV. Increased levels of a digitalis-like factor in hypertension. Fed Proc. 1981;40:535. Google Scholar10. POSTONSEWELLWILKINSON LRS. Evidence for a circulating sodium transport inhibitor in essential hypertension. Br Med J. 1981;282:847-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Medicine, and Physiology and Pharmacology Bowman Gray School of Medicine Wake Forest University Winston-Salem, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInability of Na+, K+-ATPase inhibitor to cause hypertension in sodium-loaded or deoxycorticosterone-treated one kidney ratsThe Kidney in the Pathogenesis of Hypertension: The Role of SodiumPartially purified human and rat atrial natriuretic factor.Salt, diuretics and resistance to treatment 1 October 1981Volume 95, Issue 4Page: 511-512KeywordsBlood pressureDietHormonesHypertensionIngestionNatriuretic peptidesSalts Issue Published: 1 October 1981 PDF DownloadLoading ...