tbuckley/cabot-search huggingface dataset:
Health Status in Elderly Persons Living Alone
Authors: Renzo Rozzini, Marco Trabucchi
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The demise of gatekeeping in primary care
Authors: Kamran Abbasi
Journal: Journal of the Royal Society of Medicine (2014)

Winter is coming. Our coldest months are reserved for newspaper headlines about chaos in the halls of emergency departments that teem with people desperate to seek care, warmth and, possibly, treatment. That will still happen, of course, but emergency care is almost a daily debate, the Jerry Springer Show of medicine, with each news story making a dramatic attempt to shock us more than the last. Emergency departments are inundated, we are told, crippled, even crushed. Patients are bypassing general practice, since a same day appointment is but a memory, and joining a stampede to their local hospital. The gatekeeper function of primary care is defunct. With general practice on its knees, a domino effect brings despair to emergency departments and hospitals. The system is broken. Where is the urgent fix?

Solutions become possible when we achieve clarity about the problems, especially if they happen to be informed by data. And that has been one of the issues with the emergency care debate, we don't seem to have a precise grasp of the challenges. Any change in the gatekeeper function of primary care has been difficult to pinpoint. In this issue, Thomas Cowling and colleagues bring us some much needed clarity. Their essay, with data analysis, maps out the time trends of how patients are using emergency care in England, and what this means for hospital admissions and general practice consultations.1

The authors confirm some of the speculation. Emergency care is stretched. Hospital admissions via emergency departments are rising. Patients are indeed bypassing primary care. And the gatekeeper function of primary care is disintegrating. Our existing system of urgent and emergency care has been described as unaffordable, unsustainable and fragmented. These claims may have substance, and the time trends for England are echoed by similar findings in the United States. Answers may lie in improved urgent care in general practice and a better gatekeeping service provided by emergency departments. Solutions are required quickly and they must be evaluated before scale up, say the authors, to avoid further ad hoc service developments.

A stretched service may also raise issues of patient safety and quality control. Experts in patient safety have long acclaimed the approach to safety of other industries like aviation, railways and seafaring. Now, Carl Macrae and Charles Vincent go one step further by arguing for a nimble but effective independent safety investigation body in keeping with those that exist elsewhere, like the accident investigation branches of the transport industries in the UK.2 In a statement that holds equally true for emergency care reform, the authors conclude that we must learn from the past to improve the future.
A NOVEL TRICK TO OBTAIN MORPHINE
Authors: John Asa Gibbons
Journal: JAMA (1927)

<h3>To the Editor:</h3> —A man giving the name Webster recently called on me, saying that he had been referred to me for treatment by the superintendent of the cement mills here. He claimed that he had to use sulphate of morphine in intestinal irrigations for amebic dysentery, and in support of his statement he presented what purported to be a letter from Dr. — of Nashville, Tenn. This supposed letter said that the patient was incurable and that any physician would be doing a kind act to furnish him with 40 grains of sulphate of morphine or prescribe it for him. Dr.—, by whom the supposed letter was purported to have been written, had, according to the letter, furnished the patient with scales for weighing out the quantity to be used and had given instructions as to dosage. Inquiry showed that the superintendent of the cement mills had not referred
TREATMENT OF HOOKWORM DISEASE IN PREGNANT WOMEN WITH CARBON TETRACHLORIDE
Authors: JOSÉ V. INSFRÁN
Journal: JAMA (1926)

Lambert<sup>1</sup>has recently called attention to pregnancy as a "condition in which the dire effects of hookworm disease are dramatized most vividly" and calls attention to the number of deaths annually of mother or child or both as a result of hookworm disease occurring in Fiji. Darling,<sup>2</sup>working in the same region some years ago, found that the average hemogloblin estimation for pregnant women was 15 per cent lower than that for the general population. In Paraguay, I have found a hemoglobin percentage of 64.4 for the general population (2,491 examinations), whereas the average for pregnant women (thirty-nine examinations) is but 51, which represents a loss of 13.4 per cent. In campaigns for the treatment of hookworm disease in tropical countries, where fecundity begins early and birth control is unknown, the pregnant woman has formed a large part of that group, "not treated for medical reasons," and has
Comparison of Hang-back Medial Rectus Recession with Conventional Recession
Authors: Michael X. Repka, David L. Guyton
Journal: Ophthalmology (1988)

Hang-back recession is commonly used for adjustable strabismus surgery and surgery for dissociated vertical deviation. The authors have begun to use the hang-back technique for routine recessions as well, to simplify the procedure and to lessen the risk of scleral perforation. In 49 consecutive children undergoing conventional bilateral medial rectus recession and 31 consecutive children undergoing hang-back recession, the success rate (±10 prism diopters [PD]) was 80% in the conventional group and 74% in the hang-back group at 6 weeks. The dose-response curves were nearly identical. These results confirm that hang-back recessions for infantile and acquired esotropia are a predictable alternative to conventional strabismus surgery.
Association of malignant melanoma and germ cell tumour
Authors: C.M. DWYER, D. DICK
Journal: British Journal of Dermatology (1994)

Journal Article Association of malignant melanoma and germ cell tumour Get access C.M. DWYER, C.M. DWYER Department of Dermatology, Stobhill General Hospital, Glasgow G21 3UW. U.K. Search for other works by this author on: Oxford Academic Google Scholar D. DICK D. DICK Department of Dermatology, Stobhill General Hospital, Glasgow G21 3UW. U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 1, 1 January 1994, Page 129, https://doi.org/10.1111/j.1365-2133.1994.tb06903.x Published: 01 January 1994
Group to Revamp Vector-Control Methods
Authors: Bridget M. Kuehn
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Helping Hemiparetics To Help Themselves
Authors: Joseph Brudny
Journal: JAMA (1979)

Despite the presence of some voluntary movement, the loss of discrete control impairs functioning of the arm and hand in most hemiparetics. Seventy hemiparetic patients, aged 12 to 78 years, were treated and followed up for six months to three years. Electromyographic activity monitored from dysfunctional primary movers during attempted movement was displayed to the patients as a continuous oscilloscopic trace, reflecting generated muscle activity and allowing its quantification. Coupled with operant conditioning techniques, these displays were modified gradually by reinforcing the patient's effort with auditory feedback during successive approximations to a desired level. Such therapeutic use of electromyographic displays often resulted in a progressive improvement of voluntary movement. More than half the patients acquired and retained purposive movements that meaningfully improved their functional capabilities. (<i>JAMA</i>241:814-818, 1979)
An Acknowledgment of Priority.
Authors: J. Clarence Webster
Journal: JAMA (1902)

Chicago, July 25, 1902. <h3>To the Editor:</h3> —Since writing my article, describing an improved method of examining the female bladder, I have found that Dr. William Pryor of New York read a paper before the New York County Medical Association, Jan. 21, 1901, in which he advocated the posture which I have recommended as being most advantageous in the examination of the female bladder, and which I have obtained by a slight modification of the Boldt table. I was first convinced of the value of the posture on witnessing Dr. Kelly's demonstration of his method of examining the bladder in the genupectoral position, before the British Medical Association in Montreal, and I immediately afterward adopted the Boldt table to obtain the elevated lithotomy posture, in the Royal Victoria Hospital. I am glad to acknowledge Dr. Pryor's claim to priority in this matter. Working independently, we arrived at the same conclusions,
Bell-Clapper Appearance in Scrotal Hematoma
Authors: KILLOL THAKORE, WILLIAM FAJMAN
Journal: Clinical Nuclear Medicine (1993)

Radionuclide scrotal imaging is used in cases of acute testicular pain and swelling; usually to differentiate testicular torsion from epididymitis/orchitis. Occasionally, other etiologies for the clinical findings are encountered such as hydrocele, hemorrhage, strangulated hernia, or tumor. We report a case in which a large intrascrotal hematoma resulted in the viable testis appearing as a “bell clapper.”
Abstract 4819: Wolf-Hirschhorn syndrome candidate 1, a histone lysine methyltransferase, is involved in human carcinogenesis
Authors: Ryuji Hamamoto, Masanori Yoshimatsu, Gouji Toyokawa, Hyun-Soo Cho, Yusuke Nakamura
Journal: Cancer Research (2011)

Abstract A number of histone methyltransferases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human diseases like cancer are not well understood. Here, we demonstrate that Wolf-Hirschhorn syndrome candidate 1 (WHSC1) plays an important role in human carcinogenesis. Transcriptional levels of this gene are significantly elevated in various types of cancer including bladder and lung cancers. Immunohistochemical analysis using a number of clinical tissues confirmed significant up-regulation of WHSC1 expression in bladder and lung cancer cells at the protein level. Treatment of cancer cell lines with small interfering RNAs targeting WHSC1 significantly knocked down its expression and resulted in the suppression of proliferation. Moreover, knockdown of WHSC1 decreased the cell population of cancer cells at S phase and increased that at G2/M phase through the regulation of genes involved in the Wnt signaling pathway. Furthermore, we found WHSC1 to be interacted with some proteins related to the Wnt pathway including β-catenin. As expression levels of WHSC1 are significantly low in normal tissues, it may be feasible to develop the inhibitors targeting these enzymes as anti-tumor agents which have a minimal risk of adverse reaction. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4819. doi:10.1158/1538-7445.AM2011-4819
Zileuton, 600 mg QID, Provides Early and Sustained Improvement in Pulmonary Function Compared to Placebo in Moderate and Severe Asthmatic Patients Versus Placebo
Authors: W.E. Berger, J.J. Murray, G.N. Gross, R. Menendez, K. Walton-Bowen
Journal: Journal of Allergy and Clinical Immunology (2006)
Time for food industry to adopt signposting model
Authors: Alexander Macara, Noel Olsen
Journal: BMJ (2006)

EDITOR—The BMJ of 4 February contained a full page advertisement for Walkers crisps (“You are changing and so are we”), which purports to show that crisps are becoming healthier.1 Healthier they may be; healthy they are not.

Why is Walkers making these changes now? A response to consumer demand, as the population is waking up to …
The Section on the Practice of Medicine at the Late Meeting of the Association.
Authors: Chas. G. Stockton
Journal: JAMA (1897)

Buffalo, N. Y., July 26, 1897. <h3>To the Editor:</h3> —Your editorial in the Journal of July 3, entitled " The Late Meeting of the Ophthalmic Section of theAmerican Medical Association," must have attracted the attention of all your readers. The Association meeting was bo notable in all respects that there may be danger of losing sight of the great excellence of the work in the various Sections. It may not be out of place to emphasize once more the high estimate universally expressed of the work done in the Section on the Practice of Medicine. Knowing from experience how difficult it is to arrange a program satisfactory to all of a large body of physicians, the list of papers read and the discussions brought out are recalled not only with gratification but a certain amount of wonder. It ought not to be necessary to reiterate the titles of papers
Inactivation of a Defined Active Site in the Mouse 20S Proteasome Complex Enhances Major Histocompatibility Complex Class I Antigen Presentation of a Murine Cytomegalovirus Protein
Authors: Gunter Schmidtke, Maren Eggers, Thomas Ruppert, Marcus Groettrup, Ulrich H. Koszinowski, Peter-M. Kloetzel
Journal: The Journal of Experimental Medicine (1998)

Proteasomes generate peptides bound by major histocompatibility complex (MHC) class I molecules. Avoiding proteasome inhibitors, which in most cases do not distinguish between individual active sites within the cell, we used a molecular genetic approach that allowed for the first time the in vivo analysis of defined proteasomal active sites with regard to their significance for antigen processing. Functional elimination of the δ/low molecular weight protein (LMP) 2 sites by substitution with a mutated inactive LMP2 T1A subunit results in reduced cell surface expression of the MHC class I H-2Ld and H-2Dd molecules. Surface levels of H-2Ld and H-2Dd molecules were restored by external loading with peptides. However, as a result of the active site mutation, MHC class I presentation of a 9-mer peptide derived from a protein of murine cytomegalovirus was enhanced about three- to fivefold. Our experiments provide evidence that the δ/LMP2 active site elimination limits the processing and presentation of several peptides, but may be, nonetheless, beneficial for the generation and presentation of others.
Harvey Cushing: A Life in Surgery
Authors: B. Lichterman
Journal: BMJ (2006)

<h3>Introduction</h3> Rivaroxaban, a factor Xa inhibitor used as a direct oral anticoagulant, is beneficial over warfarin in terms of food–drug interactions and the need for therapeutic monitoring in patients with acute venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism. Because there is little data regarding VTE treatment in Japan, a real-world survey of Japanese patients being treated with rivaroxaban for VTE is needed. <h3>Methods and analysis</h3> The Japanese Registry of Rivaroxaban Effectiveness &amp; Safety for the Prevention of Recurrence in Patients with Deep Vein Thrombosis and Pulmonary Embolism has been established to investigate the clinical outcomes of rivaroxaban for the initial treatment and prevention of symptomatic recurrent VTE in Japanese patients with acute symptomatic/asymptomatic VTE. 150 institutions in Japan will enrol patients in the study; the target enrolment is 1000. All patients will be followed up two times a year for at least 18 months and up to 3 years after their enrolment. The primary outcome is symptomatic recurrent VTE occurring during the study period. The principal safety outcome is clinically relevant bleeding (ie, major bleeding or clinically relevant non-major bleeding) occurring during treatment. A clinical events committee will adjudicate all outcomes. <h3>Ethics and dissemination</h3> The study protocol has been approved by the Nihon University Itabashi Hospital, Clinical Research Ethics Committee and all local institutional ethics committees of the participating hospitals. Findings of the study will be presented in scientific sessions and will be published in peer-reviewed journals. <h3>Trial registration number</h3> NCT03091621,UMIN000025072; Pre-results.
Validation of a community-based survey assessing non-obstetric surgical conditions in Burera District, Rwanda
Authors: Allison F Linden, Rebecca Maine, Bethany L Hedt-Gauthier, Emmanual Kamanzi, Gita Mody, Georges Ntakiyiruta, Grace Kansayisa, Edmond Ntaganda, Francine Niyonkuru, Joel Mubiligi, Tharcisse Mpunga, John G Meara, Robert Riviello
Journal: The Lancet (2015)
Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: data from the Italian ipilimumab expanded access programme (EAP)
Authors: Paolo Antonio Ascierto, E Simeone, V Chiarion Sileni, P Queirolo, M Del Vecchio, L Di Guardo, M Guidoboni, P Marchetti, GC Antonini Cappellini, PF Ferrucci, F Cognetti, MG Bernengo, M Guida, R Marconcini, M Mandalà, C Cimminiello, G Rinaldi, M Aglietta, L Calabrò, M Maio
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Data to guide the order in which ipilimumab and vemurafenib are used in patients with advanced melanoma are limited. Here are reported outcomes from patients treated in the ipilimumab EAP who received both drugs. Patients with pretreated, BRAFV600 mutation-positive advanced
Antidepressant Medication and Spontaneous Abortion
Authors: Catalin Tufanaru, Jon Jureidini
Journal: JAMA Psychiatry (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Salmeterol xinafoate in the treatment of mild to moderate asthma in primary care. UK Study Group.
Authors: K P Jones
Journal: Thorax (1994)

Clinical studies of inhaled salmeterol xinafoate have been conducted mainly in moderately to severely affected asthmatic subjects in hospital settings. This study was conducted to investigate the effectiveness of this drug in patients with milder asthma in primary care.A multicentre, double blind, randomised, parallel group comparison of salmeterol xinafoate in a dose of 50 micrograms twice daily with placebo, both administered from a four-place dry powder inhaler (Diskhaler), was performed over six weeks in United Kingdom general practices.A total of 427 asthmatic patients aged 18 years or older were randomised to receive salmeterol or placebo in a 2:1 ratio. Of the total randomised population, 247 patients were previously on short acting bronchodilators alone whilst 180 patients were concurrently receiving up to 400 micrograms inhaled corticosteroid. Mean morning peak expiratory flow rose more in the salmeterol group than in the placebo group (treatment difference 17 l/min, 95% confidence interval 9 to 26 l/min) but there was a smaller, non-significant difference in mean evening peak expiratory flow. Improvements occurred in the salmeterol-treated group compared with placebo for wheeze, shortness of breath, undisturbed nights, and relief medication use, irrespective of concomitant inhaled corticosteroid use. In addition, improvement in activity restriction was seen in the salmeterol group compared with placebo in the subgroup receiving only bronchodilator.Salmeterol is effective and well tolerated in the short term in mildly asthmatic adult patients irrespective of concomitant use of inhaled corticosteroid therapy.