tbuckley/cabot-search huggingface dataset:
Abstract 1049: DNMT3b increases transformation efficiency and accelerates carcinogen induced transformation of human bronchial epithelial cells
Authors: Ivo Teneng, Carmen S. Telles, Steven A. Belinsky
Journal: Cancer Research (2012)

Abstract Malignant tumors and cell lines are characterized by increased expression of DNMT1, DNMT3a and DNMT3b. While evidence suggests that DNMT1, DNMT3a and DNMT3b co-operate in methylation and gene silencing during carcinogenesis, very little is known regarding gene targets for DNMT3a and DNMT3b and their impact on the development of adenocarcinoma. We developed an in vitro model using human telomerase/cyclin dependent kinase 4-immortalized human bronchial epithelial cell lines (HBECs) to identify key molecular changes that drive transformation and clonal outgrowth of preneoplastic lung epithelial cells during exposure to tobacco carcinogens. Carcinogen exposure (0.5mM MNU and 0.05µM BPDE) for 12 weeks induced transformation of HBEC2 cells and transformation efficiency was associated with DNA repair capacity. A significant increase in DNMT1 protein was observed during carcinogen exposure while moderate increases in DNMT3a and DNMT3b were observed in transformed cells. Increased DNMT3a and DNMT3b levels have been reported in several cancers. We observed 5-20 fold increased expression of DNMT3a and DNMT3b in tumor derived lung cancer cell lines. Therefore we tested the hypothesis that over expressing DNMT3a and DNMT3b would accelerate transformation by targeting specific genes for methylation and promote full malignancy in carcinogen-treated HBECs. Over expression of DNMT3a or DNMT3b did not affect DNA repair capacity and was not sufficient to drive spontaneous transformation as evidenced by inability to form colonies on soft agar. Transformation efficiency was increased 2-2.5 fold in the two HBEC2 cell lines over expressing DNMT3b after 12 weeks of carcinogen treatment relative to treated parental HBEC2. In addition, after 8 weeks, colony formation was evident in the DNMT3b over expressing, but not in parental HBECs indicating that increased expression of this de novo DNMT accelerates transformation. Over expressing DNMT3a had no effect on carcinogen-induced transformation. Current studies are evaluating global re-programming of the epigenome in transformed clones using the Illumina 450k promoter array and the effect of over expression of DNMT3b on stem cell markers. This study was supported by R01 ES008801 to S.A.B. and 1F32 CA157082 to I.T. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1049. doi:1538-7445.AM2012-1049
A randomized trial of the addition of home‐based exercise to specialist heart failure nurse care: the Birmingham Rehabilitation Uptake Maximisation study for patients with Congestive Heart Failure (BRUM‐CHF) study
Authors: Kate Jolly, Rod S. Taylor, Gregory Y.H. Lip, Mick Davies, Russell Davis, Jonathan Mant, Sally Singh, Sheila Greenfield, Jackie Ingram, Jane Stubley, Stirling Bryan, Andrew Stevens
Journal: European Journal of Heart Failure (2009)
Broad-Spectrum G Protein–Coupled Receptor Antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: A Dual Inhibitor of Growth and Angiogenesis in Pancreatic Cancer
Authors: Sushovan Guha, Guido Eibl, Krisztina Kisfalvi, Robert S. Fan, Marie Burdick, Howard Reber, Oscar J. Hines, Robert Strieter, Enrique Rozengurt
Journal: Cancer Research (2005)

Abstract Substance P analogues, including [D-Arg1,D-Trp5,7,9,Leu11]SP (SPA) are broad-spectrum G protein–coupled receptor (GPCR) antagonists that have potential antitumorigenic activities, although the mechanism(s) are not completely understood. Here, we examined the effects of SPA in ductal pancreatic cancers that express multiple GPCRs for mitogenic agonists and also produce proangiogenic chemokines. Using HPAF-II, a well-differentiated pancreatic cancer cell line as our model system, we showed that SPA inhibited multiple neuropeptide-induced Ca2+ mobilization, DNA synthesis, and anchorage-independent growth in vitro. SPA also significantly attenuated the growth of HPAF-II tumor xenografts in nude mice beyond the treatment period. Interestingly, SPA markedly increased apoptosis but moderately decreased proliferation marker, Ki-67 in the tumor xenografts implying additional mechanism(s) for the significant growth inhibitory effect observed in vivo. HPAF-II cells express ELR+ CXC chemokines, including IL-8/CXCL8, which bind to CXCR2 (a member of GPCR superfamily) and promote angiogenesis in multiple cancers, including pancreatic cancer. SPA inhibited CXCR2-mediated Ca2+ mobilization and blocked specifically IL-8/CXCL8-induced angiogenesis in rat corneal micropocket assay in vivo. A salient feature of the results presented here is that SPA markedly reduced tumor-associated angiogenesis in the HPAF-II xenografts in vivo. Our results show that SPA, a broad-spectrum GPCR antagonist attenuates tumor growth in pancreatic cancer via a dual mechanism involving both the antiproliferative and antiangiogenic properties. We conclude that this novel dual-inhibitory property of SPA could be of significant therapeutic value in pancreatic cancer, when used in combination with other antiproliferative and/or antiangiogenic agents.
The value of monitoring minimal residual disease in the patients with donor lymphocyte infusion as intervention of relapsed/refractory acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation
Authors: Xiao Ma, Depei Wu, Aining Sun, Huiying Qiu, Zhenzhen Fu, Xiaojin Wu, Suning Chen, Mohamad Mohty
Journal: American Journal of Hematology (2009)
Recent results of health examinations on the general population in cadmium-polluted and control areas in Japan.
Authors: I Shigematsu, M Minowa, T Yoshida, K Miyamoto
Journal: Environmental Health Perspectives (1979)

Health examinations by a revised method aimed at detecting renal tubular dysfunctions more effectively were conducted on the general population aged 50 years and over in cadmium-polluted areas (1826 persons) and control areas (1611 persons) in four prefectures in Japan in 1976. Although detailed analysis of the data is not yet completed, some of the results obtained are described here. The prevalence of glucosuria and low molecular weight proteinuria, frequency of decreased % TRP, and cadmium concentrations in urine are higher in the cadmium-polluted areas than in the controls. Clinically diagnosed cases with tubular dysfunctions seem to follow the same trend as above, though these cases are very few in number and they are limited to the advanced age group. When cadmium concentration in rice is taken as an index, a dose-response relationship is not necessarity explicit in the observations by prefecture. However, suggestive data are obtained in the observation by district in one cadmium-polluted area.
Association of cardiovascular disease risk factors with socioeconomic position during childhood and during adulthood
Authors: D Blane, C L Hart, G D. Smith, C R Gillis, D J Hole, V M Hawthorne
Journal: BMJ (1996)

To investigate strength of associations between risk factors for cardiovascular disease and socioeconomic position during childhood and adulthood.Cross sectional analysis of status of cardiovascular risk factors and past and present social circumstances.5645 male participants in the west of Scotland collaborative study, a workplace screening study.Strength of association between each risk factor for cardiovascular disease (diastolic blood pressure, serum cholesterol concentration, level of recreational physical exercise, cigarette smoking, body mass index, and FEV1 score (forced expiratory volume in one second as percentage of expected value) and social class during childhood (based on father's main occupation) and adulthood (based on own occupation at time of screening).All the measured risk factors were significantly associated with both father's and own social class (P < 0.05), apart from exercise and smoking (not significantly associated with father's social class) and body mass index (not significantly associated with own social class). For all risk factors except body mass index, the regression coefficient of own social class was larger than the regression coefficient of father's social class. The difference between the coefficients was significant for serum cholesterol concentration, cigarette smoking, body mass index, and FEV1 score (all P < 0.001).Subjects' status for behavioural risk factors (exercise and smoking) was associated primarily with current socioeconomic circumstances, while status for physiological risk factors (serum cholesterol, blood pressure, body mass index, and FEV1) was associated to varying extents with both past and present socioeconomic circumstances.
High nucleotide sequence variation in a region of low recombination in Drosophila simulans is consistent with the background selection model
Authors: M. T. Hamblin, C. F. Aquadro
Journal: Molecular Biology and Evolution (1996)

We surveyed nucleotide sequence variation at glucose dehydrogenase (Gld), in a region of low recombination on chromosome 3R, from a population sample of Drosophila simulans. The levels of nucleotide variation were surprisingly high. There was no departure from the expectation of a neutral model for the level of polymorphism, indicating no evidence of a selective sweep in this region. There was a significant deficiency of singleton polymorphisms according to the Fu and Li test, although Tajima and Hudson, Kreitman, and Aguade (HKA) tests do not provide evidence of a significant elevation of variation due to balancing selection. Genetic map data for the D. simulans third chromosome were used to calculate expected values of pi for Gld under a current model of background selection, varying the values for the parameter sh (selection coefficient against deleterious mutations). We show that the recombinational landscape of D. simulans is sufficiently different from that of D. melanogaster that we expect higher variation under the background selection model, even when effective population sizes are assumed to be equal. The data for Gld were tested against the predictions using computer simulations of the distribution of the number of segregating sites conditioned on pi. Background selection alone can explain our observations as long as sh is larger than 0.005 and species-level effective population size is assumed to be several-fold larger than in D. melanogaster. Alternatively, the deleterious mutation rate may be smaller in D. simulans, or balancing selection may be acting nearby, thereby reducing the effect of background selection.
On the Production of Heat in Fever
Authors: W. W. Moore
Journal: BMJ (1884)

trophy that the 8ubject may live for many rears, is Wa& iilustrMeO by a case in whirch"aute rheuniatism`at the age of 14,in 18681ldft behind regurgit4lon, attended with a maximum amount' of dilata- $is and hypertrophy', together with s9dondary mitral 'regurgitation Aid exaggerated signs of eVery lkind, which the patienit strvived f6i fourteen years, earning his livelihood as a greengrocer.He died suddenly in 'May 1882, during convalescence from slight sub- acute rheumatism, when the aortic valves were found to be prac- tically non-existent, and thb hearft weighed 42, ounces.Whten, on the other hand, aortic regurgitation comes on late in life, partly from the fact that it will in most cases be progressive, id pa.rtly from the-dimijrished aptitude of the 'heart to' undergo cominjensatory changes, the prognosis is iost grave; An example was related, in which a fatal terminatioli followed the establishment of the disease in a gentleman aged 34, at an interval, of only sixteen months.In these cases, the preseace or absence of the aortic 9eoond sound in the neck is of extreme importance.The unfavour- able prognosis dates from its disuppearance, which in some cases is dtlayed for a considerable time.We have still to trace the symptoms which lead up to a fatal ter-'mdfination in the form of valvular disease under consideration.They !,'11 into two series, according as the ultimate effect on the circula- tion is arterial stagnation, from lack of vis h tergo, so-called asystole, or venous obstruction.In the former class, there occur syncopal and anginoid attacks, paroxysms of dyspncea, a sense of oppression ihi the chest, paix in the cardiac region, irregularity and intermis- sion of the pulse and heart-beat, which replace the regularity 1011 44 1010 .
TEXAS AS A CLIMATE FOR CONSUMPTION.
Authors: F. D. MARSHALL
Journal: JAMA (1893)

<h3>Mr. President and Members of the American Health Resort Association:</h3> —My attention was first directed to the climate of Texas as a fit place for consumptives in the spring of 1868. Dr. J. Scoonover a classmate of mine had just graduated from the College of Physicians and Surgeons, of New York: and was now physically a wreck. The doctor had been a hard student for several years and had a family history that was unmistakable, having lost two brothers of consumption. Dr. Metcalf of New York, after a careful examination of the case advised him to go to Texas or Florida, he chose the former place having some knowledge of the country. Dr. Scoonover's case was an unmistakable one of tubercular deposit in the right lung as shown by physical examination and confirmed by great emaciation and spitting of blood. His case seemed hopeless, but with small means at his
Pharmacologic and Nutritional Treatment of Mild Hypertension: Changes in Cardiovascular Risk Status
Authors: Albert Oberman
Journal: Annals of Internal Medicine (1990)

Objective: To evaluate the 6-month change in cardiovascular (coronary heart disease) risk as a function of diet and drug therapy for mild hypertension. Design: Collaborative randomized, controlled clinical trial to assess the efficacy of alternative regimens in treating mild hypertension. Setting: Three university-based tertiary care centers—the Trial of Antihypertensive Interventions and Management (TAIM). Patients: Six hundred and ninety-two men and women ages 21 to 65 years with diastolic blood pressure between 90 and 100 mm Hg and weight between 110% and 160% of ideal weight. Measurements and Main Results: Patients stratified by clinical center and race were randomized into diet (usual, low sodium-high potassium, weight loss) and drug (placebo, chlorthalidone, and atenolol) groups resulting in nine diet plus drug combinations. The cardiovascular risk at 6-month follow-up was estimated relative to baseline in 692 participants using the Framingham Study model. Due to the blood pressure reduction, cardiovascular risk declined from baseline for all treatment groups (except the usual diet plus chlorthalidone group because of increased cholesterol levels). The relative cardiovascular risk at 6 months compared to baseline ranged from 0.83 in the weight loss plus atenolol subgroup to 1.03 in the usual diet plus chlorthalidone sub-group. The active drug plus weight loss groups showed the lowest relative cardiovascular risk at 6 months. Conclusions: Mild hypertension was generally reduced to desirable levels within 6 months by monotherapy. Evaluating blood pressure changes together with the risk factors indicated a differential effect on overall cardiovascular risk depending on the diet and drug used. Dietary therapy, particularly weight reduction, was important adjunctive treatment in reducing overall cardiovascular risk.
Smoking and inflammatory bowel disease. A case control study.
Authors: E Lindberg, C Tysk, K Andersson, G Jarnerot
Journal: Gut (1988)

A population case controlled study of smoking habits at the time of diagnosis was done in 260 patients with ulcerative colitis and 144 with Crohn9s disease. Smokers had a decreased risk of acquiring ulcerative colitis in comparison with never smokers (relative risk 0.7) which appeared to be dose dependent. In former smokers a rebound effect was seen, especially in former heavy smokers, where the risk was sharply increased (relative risk 4.4). No sex difference was recorded. Smoking doubled the risk of acquiring Crohn9s disease without any dose dependent pattern. In former smokers a non-significantly increased risk was observed. This might be caused by a carry over effect after stopping smoking, however, which possibly is reduced by time. No sex difference was seen.
London Maternity Catchment Areas
Authors: T. G. Hovenden
Journal: BMJ (1964)

BRmTIsH 1513individual case is unimportant, however bad; the principle is clear.If the disciplinary procedure of the N.H.S. is to include the laying down of what is "good " or " bad " doctoring then I, for one.will require to see in the terms of service some pretty exhaustive and stringent definitions, and it may be that we shall have to abandon our present easy-going informal procedure that Dr. Dain spent so many years building up.-I am, etc.,
Abstract A28: Aberrant c-Myc protein stabilization and Axin1 deregulation in acute leukemia
Authors: Deanne C. Tibbitts, William Fleming, Guang Fan, Rosalie Sears
Journal: Cancer Research (2009)

Abstract The c-Myc oncoprotein is an important regulator of cellular growth, proliferation, differentiation, and apoptosis, and c-Myc expression is commonly increased in cancer. Historically, increased c-Myc expression in hematopoietic cancers has been explained by gene amplification or chromosomal translocations that deregulate its transcription. Recent work from our lab suggests that deregulated phosphorylation of c-Myc associated with disrupted c-Myc degradation constitutes an additional mechanism by which c-Myc can drive cancer. We have previously shown that c-Myc degradation is regulated by hierarchical phosphorylation at 2 conserved sites, serine 62 (S62) and threonine 58 (T58), and is coordinated by the scaffold protein and tumor suppressor Axin1. Building on our previous work showing that in a variety of human leukemia cell lines c-Myc is aberrantly stabilized with altered phosphorylation at T58 and S62, we are examining the prevalence and potential mechanism of increased c-Myc stability in primary acute myelogenous leukemia (AML), T cell acute lymphoblastic leukemia (ALL), and B cell ALL patient samples. Based on our recent work showing that c-Myc protein stability is negatively regulated by Axin1, we are examining mechanisms of Axin1 deregulation in AML and ALL patient samples. Finally, by manipulating Axin1 in both leukemic and non-transformed hematopoietic cell lines, we will investigate Axin1's role in directly controlling c-Myc stability and phosphorylation in hematopoietic lineages and whether Axin1 may be a potential therapeutic target in acute leukemias. Citation Information: Cancer Res 2009;69(23 Suppl):A28.
GENERATION GAP: INTRA- AS WELL AS INTER-
Authors: ALEX M. BURGESS
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 March 1969GENERATION GAP: INTRA- AS WELL AS INTER-ALEX M. BURGESS SR., M.D., F.A.C.P.ALEX M. BURGESS SR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-3-650 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:I have just finished reading for the second time your editorial letter to "Dear Miranda" (Ann. Intern. Med. 69: 1322, 1968). It is such an excellent job that I wish it could be reprinted and given a larger group of readers than those of the medical profession who see the ANNALSand read editorials. You covered the major sicknesses of our world so clearly that I cannot see how it could be better done. As an "old timer"—one generation back of yours—the contrast betweennowand those days of my young adult life is certainly even more... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALEX M. BURGESSSR., M.D., F.A.C.P.Affiliations: 107 Bowen St. Providence, R. I. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1969Volume 70, Issue 3Page: 650-652KeywordsYoung adults ePublished: 1 December 2008 Issue Published: 1 March 1969 PDF downloadLoading ...
Successful treatment by double-filtration plasmapheresis of a patient with bullous pemphigoid: effects in vivo on transcripts of several genes for chemokines and cytokines in peripheral blood mononuclear cells
Authors: Y. Hatano, K. Katagiri, S. Arakawa, T. Umeki, S. Takayasu, S. Fujiwara
Journal: British Journal of Dermatology (2003)

Journal Article Successful treatment by double‐filtration plasmapheresis of a patient with bullous pemphigoid: effects in vivo on transcripts of several genes for chemokines and cytokines in peripheral blood mononuclear cells Get access Y. Hatano, Y. Hatano Department of Dermatology, Oita Medical University, 1‐1 Idaigaoka, Hasama‐machi, Oita‐gun, Oita 879‐5593, Japan Dr Yutaka Hatano. E‐mail: HATANO@oita‐med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar K. Katagiri, K. Katagiri Department of Dermatology, Oita Medical University, 1‐1 Idaigaoka, Hasama‐machi, Oita‐gun, Oita 879‐5593, Japan Search for other works by this author on: Oxford Academic Google Scholar S. Arakawa, S. Arakawa Department of Dermatology, Oita Medical University, 1‐1 Idaigaoka, Hasama‐machi, Oita‐gun, Oita 879‐5593, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Umeki, T. Umeki Department of Dermatology, Oita Medical University, 1‐1 Idaigaoka, Hasama‐machi, Oita‐gun, Oita 879‐5593, Japan Search for other works by this author on: Oxford Academic Google Scholar S. Takayasu, S. Takayasu Department of Dermatology, Oita Medical University, 1‐1 Idaigaoka, Hasama‐machi, Oita‐gun, Oita 879‐5593, Japan Search for other works by this author on: Oxford Academic Google Scholar S. Fujiwara S. Fujiwara Department of Dermatology, Oita Medical University, 1‐1 Idaigaoka, Hasama‐machi, Oita‐gun, Oita 879‐5593, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 3, 1 March 2003, Pages 573–579, https://doi.org/10.1046/j.1365-2133.2003.05233.x Published: 01 March 2003 Article history Accepted: 30 September 2002 Published: 01 March 2003
Detection of Papillary Thyroid Cancer Brain Metastasis With FDG-PET/CT
Authors: Josephine N. Rini, Vinh T. Nguyen, Eran Ben-Levi, Jason J. Naidich, Jian Yi Li, Christopher J. Palestro
Journal: Clinical Nuclear Medicine (2010)

A 70-year-old woman with a history of papillary thyroid carcinoma metastatic to lung and arm muscle previously was treated with total thyroidectomy, pneumonectomy, excision of an intramuscular lesion, and I-131 therapy. Because of an elevated serum thyroglobulin level, she underwent Thyrogen-stimulated F-18 fluorodeoxyglucose PET/CT (FDG-PET/CT) and whole body I-131 scan. FDG-PET/CT demonstrated a hypermetabolic lesion within the right cerebellum (maximum SUV 18.3). Whole body I-131 scan was negative. Magnetic resonance imaging performed 2 weeks later demonstrated a 1.3 × 0.9 cm enhancing lesion in the right cerebellum, suspicious for metastasis. The patient subsequently underwent a craniotomy and excision of the mass. Pathologic evaluation confirmed a brain metastasis secondary to papillary thyroid carcinoma.