tbuckley/cabot-search huggingface dataset:
Abstract 412: SEC11A contributes to malignant progression through promotion of EGF and TGF-α secretion in gastric cancer.
Authors: Naohide Oue, Tetsutaro Hayashi, Reiko Ito, Akiko Nagatsuma, Kazuhiro Sentani, Naoya Sakamoto, Katsuhiro Anami, Naohiro Uraoka, Yutaka Naito, Kazuyoshi Yanagihara, Atsushi Ochiai, Hiroki Sasaki, Wataru Yasui
Journal: Cancer Research (2013)

Abstract Gastric cancer (GC) is one of the most common human cancers. We previously performed Serial Analysis of Gene Expression (SAGE) on four primary GCs and identified several GC-specific genes. In the present study, we have built an in-house oligonucleotide array on which 394 genes selected based on our SAGE data and previously reported array data to allow for the study of the genes that are most relevant to gastric carcinogenesis. We focused on the SEC11A gene, which encodes SPC18 protein. SPC18 is one of the member of signal peptidase complex. SPC18 mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in GC tissue samples. Expression and distribution of SPC18 protein was investigated by immunohistochemistry in two independent GC cohorts (Hiroshima cohort, n = 99 and Chiba cohort, n = 989). To determine the effect of SPC18 on cell growth and invasiveness in vitro, MTT and Boyden chamber invasion assays were performed. To evaluate the influence of SPC18 on cell growth in vivo, GC cells were injected into SCID mice. The levels of TGF-α and EGF in media from the GC cells were measured by ELISA. Overexpression of SEC11A mRNA was observed in 40% of GC cases by qRT-PCR. Immunohistochemical analysis of SPC18 revealed that 26% of GC cases were positive for SPC18 in Hiroshima cohort and 20% of GC cases were positive for SPC18 in Chiba cohort. SPC18-positive GC cases showed poorer survival than SPC18-negative GC cases in both Hiroshima cohort and Chiba cohort by Kaplan-Meier analysis. Forced expression of SPC18 activates GC cell growth in vitro and in vivo. The levels of TGF-α and EGF in culture media from GC cells were reduced by knockdown of SPC18. These results indicate that SPC18 contributes to malignant progression through promotion of EGF and TGF-α secretion in GC. Citation Format: Naohide Oue, Tetsutaro Hayashi, Reiko Ito, Akiko Nagatsuma, Kazuhiro Sentani, Naoya Sakamoto, Katsuhiro Anami, Naohiro Uraoka, Yutaka Naito, Kazuyoshi Yanagihara, Atsushi Ochiai, Hiroki Sasaki, Wataru Yasui. SEC11A contributes to malignant progression through promotion of EGF and TGF-α secretion in gastric cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 412. doi:10.1158/1538-7445.AM2013-412
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
Authors: A Larson Gedman, Q Chen, S Kugel Desmoulin, Y Ge, K LaFiura, C L Haska, C Cherian, M Devidas, S B Linda, J W Taub, L H Matherly
Journal: Leukemia (2009)
Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
Authors: Bas Brouwers, Geoffroy de Faudeur, Anna B. Osipovich, Lotte Goyvaerts, Katleen Lemaire, Leen Boesmans, Elisa J.G. Cauwelier, Mikaela Granvik, Vincent P.E.G. Pruniau, Leentje Van Lommel, Jolien Van Schoors, Jennifer S. Stancill, Ilse Smolders, Vincent Goffin, Nadine Binart, Peter in’t Veld, Jeroen Declercq, Mark A. Magnuson, John W.M. Creemers, Frans Schuit, Anica Schraenen
Journal: Cell Metabolism (2014)
Violence and overcrowding characterise many mental health wards in England
Authors: A. Cole
Journal: BMJ (2008)

A comprehensive survey of England’s mental health wards has identified high levels of violence, overcrowding, and impersonal care, and 11 of the 69 trusts surveyed failed to meet minimum standards.

The health watchdog the Healthcare Commission also found that many detained patients are leaving the wards without permission and putting themselves or others at risk. During a six month period patients were recorded leaving the ward on 2745 occasions for an average of three days.

The commission examined in detail the performance of 554 mental health wards in England that provide almost 10 000 beds for patients between the ages of 18 and …
Hodgkin's disease presenting with hypoadrenalism.
Authors: C Feinmann, R Gillett, M H Irving
Journal: BMJ (1976)

TABLE II-Comparison of effect of practolol and atenolol on cardiac output (measured in only 11 patients) and blood gases.Results are means ± SE Cardiac output Paco2 Pao, (1/min) (kPa) (kPa) At rest (5 mitnutes) Practolol 6.66 ±053 49-0 12 11 3±036 Atenolol 6 40 ±0 48 4-8 t0 15 11-5 ±0 44 Exercise Practolol .. 12 67±116 5-2±0-21 12-9±0-41 Atenolol 11-02 083 51 ±0 16 119±044 At 45 mintuites Practolol 735 -0 72 4.7 i0-15 11-2 ±0 44 Atenolol 6 23 ±040 4-8 ±0 11 11-2±0 36 5 minutes after isoprenaline (at 50 minuztes) Practolol 7-65 10 76 Atenolol 6-67 +0 72 20 minutes after isoprenialitne (at 65 miiinuites)
CT colonography had 90% sensitivity and 86% specificity for diagnosing large adenomas and cancer in asymptomatic adults
Authors: Fay Kastrinos
Journal: Annals of Internal Medicine (2009)

ACP Journal Club17 February 2009CT colonography had 90% sensitivity and 86% specificity for diagnosing large adenomas and cancer in asymptomatic adultsFay Kastrinos, MD, MPH, Benjamin Lebwohl, MD, Alfred I. Neugut, MD, PhDFay Kastrinos, MD, MPHColumbia University Medical Center, New York, New York, USA (F.K., B.L., A.I.N.)Search for more papers by this author, Benjamin Lebwohl, MDColumbia University Medical Center, New York, New York, USA (F.K., B.L., A.I.N.)Search for more papers by this author, Alfred I. Neugut, MD, PhDColumbia University Medical Center, New York, New York, USA (F.K., B.L., A.I.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-4-200902170-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationJohnson CD, Chen MH, Toledano AY, et al. Accuracy of CT colonography for detection of large adenomas and cancers. N Engl J Med. 2008;359:1207-17. https://pubmed.ncbi.nlm.nih.gov/18799557Clinical Impact RatingsGastroenterology: Reference1 Whitlock EP, Lin JS, Liles E, Beil TL, Fu R. Screening for colorectal cancer: a targeted, updated systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2008;149:638-58. [PMID: 18838718] Google Scholar Author, Article, and Disclosure InformationAffiliations: Columbia University Medical Center, New York, New York, USA (F.K., B.L., A.I.N.)This article was published at Annals.org on 3 February 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 February 2009Volume 150, Issue 4Page: JC2-13KeywordsAdenomasColonColonoscopyColorectal cancerComputed axial tomographyDiagnostic radiologyLesionsRadiologistsRectumSpecificity ePublished: 17 February 2009 Issue Published: 17 February 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Family study of lipid and purine levels in gout patients.
Authors: L G Darlington, J Slack, J T Scott
Journal: Annals of the Rheumatic Diseases (1982)

A family study was performed to determine whether the hypertriglyceridaemia associated with gout is present in families of gout patients or due to the life style of the patient himself. The study revealed the expected hypertriglyceridaemia in gout patients; this was reflected by elevated serum levels of prebetalipoproteins and with reduction in the proportion of beta-lipoprotein. None of these abnormalities were seen in the first-degree relatives. Furthermore, the proportion of high-density lipoproteins was not significantly raised in gout patients.
Role of Epidermal Growth Factor Inhibition in Experimental Pulmonary Hypertension
Authors: Bhola Kumar Dahal, Teodora Cornitescu, Aleksandra Tretyn, Soni Savai Pullamsetti, Djuro Kosanovic, Rio Dumitrascu, Hossein Ardeschir Ghofrani, Norbert Weissmann, Robert Voswinckel, Gamal-Andre Banat, Werner Seeger, Friedrich Grimminger, Ralph Theo Schermuly
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Epidermal growth factor (EGF) and its receptors play a role in cell proliferation and survival and are implicated in the pathobiology of pulmonary arterial hypertension (PAH).To study the role of EGF inhibition on experimental pulmonary hypertension.We investigated (1) the effects of three clinically approved EGF receptor (EGFR) antagonists in vitro on rat pulmonary arterial smooth muscle cell proliferation and in vivo on experimental pulmonary hypertension (PH) induced by monocrotaline injection in rats and by chronic hypoxia in mice, and (2) the expression of EGFR in the lung tissues from experimental and clinical PH.The EGFR inhibitors gefitinib, erlotinib, and lapatinib inhibited the EGF-induced proliferation of pulmonary arterial smooth muscle cells. In rats with established PH, gefitinib and erlotinib significantly reduced right ventricular systolic pressure and right ventricular hypertrophy. In addition, the medial wall thickness and muscularization of pulmonary arteries were improved. In contrast, lapatinib did not provide therapeutic benefit. These EGFR antagonists at their highest tolerable dose did not yield significant improvement in right ventricular systolic pressure, right ventricular hypertrophy, and pulmonary vascular remodeling in mice with chronic hypoxic PH. Moreover, no significant alteration in the EGFR expression was detected in the lung tissues from patients with idiopathic PAH.The partial therapeutic efficacy of the EGFR antagonists in animal models of pulmonary hypertension and the absence of significant alteration in EGFR expression in the lungs from patients with idiopathic PAH suggest that EGFRs do not represent a promising target for the treatment of pulmonary hypertension.
Social class differences in years of potential life lost: size, trends, and principal causes.
Authors: D Blane, G D Smith, M Bartley
Journal: BMJ (1990)

British social class differences in mortality are examined in terms of years of potential life lost, a measure that gives more weight to deaths that take place at younger ages. It shows wider class differences during the years of working life than those found when mortality is expressed in terms of standardised mortality ratios. Examination of the change in class differences between 1971 and 1981 for all causes of death combined and for the three categories of death which during these ages make a major contribution to total years of potential life lost shows complex changes. Inequalities in years of potential life lost have increased between 1971 and 1981, during which all the principal causes of death have shown stationary or rising rates among the manual classes. The use of years of potential life lost as a measure of population health trends focuses attention on the major contribution of violent death, which occurs mainly in younger men, to widening class differences in mortality.
Autoantibodies may cause bronchospasm in adults
Authors: William A. Check
Journal: JAMA (1980)

Scientists have opened up a possible new approach to understanding bronchospasm in asthma sufferers with the finding that many patients with airway obstruction have substantial amounts of antibody to the receptor that, when bound to epinephrine, produces bronchial relaxation. The search for such autoantibodies became possible when the cell receptor involved, the β<sub>2</sub>-adrenergic receptor, was purified in the laboratory of J. Craig Venter, PhD, of the Department of Pharmacology and Therapeutics at the State University of New York at Buffalo. In healthy persons, epinephrine binding to the β<sub>2</sub>-adrenergic receptor causes bronchial smooth muscle to relax. However, in persons with asthma, according to one prevailing theory, bronchospasm may occur because these receptors are less sensitive to epinephrine. Venter and colleagues reasoned that this loss of sensitivity might be caused in some persons by antibodies to the receptor, just as myasthenia gravis is most likely caused by antibodies
P4-17-02: Whole-Brain Radiation Therapy Plus Concomitant Temozolomide for the Treatment of Brain Metastases from Breast Cancer: A Randomized Prospective Multicenter Phase II Study.
Authors: YM Kirova, D Hajage, S Gerber, Scodan R Le, J-Y Pierga, C Bourgier, F Campana, B Asselain, A Fourquet, C Levy
Journal: Cancer Research (2011)

Abstract BACKGROUND: A previously published study of temozolomide (TMZ) concurrent with whole-brain radiation therapy (WBRT) reported significant improvement in response rates and a nonsignificant trend toward improved overall survival compared with WBRT alone in patients with brain metastases in different type of tumors. A prospective randomized phase II trial of concurrent WBRT and TMZ versus WBRT alone was conducted to assess whether the concurrent use of WBRT-TMZ resulted in measurable radiological response differences at 6 weeks after the treatment in homogeneous population of breast cancer (BC) patients. PATIENTS AND METHODS: In this intent-to-treat study, patients with metastatic breast cancer to the brain and not suitable for surgery or radio-surgery were enrolled in a randomized prospective multicenter phase II study between February 2008 and December 2010. Patients received temozolomide 75 mg/m(2)/day (days 1–15) concurrently with WBRT 30 Gy/10 fractions. Patients were stratified by type and metastatic sites. The (MRI) response at 6 weeks was the main criteria; response was defined as complete (CR) or partial response (PR). Initial and follow-up MRI were realized on a 1.5T unit (Siemens) by axial SE-T1 WIs and FLAIR WIs with GdDTA injection, EG-3DT1 WIs after GdDTPA. Five target lesions (over 10 mm greatest diameter) were measured in their 3 dimensions. Non measurable lesions were noticed."The treatment tolerance and clinical responses were also evaluated. The study was designed according to a modified Fleming two-stage plan based on response hypotheses of 30% (H0) versus 50% (H1). Twenty or more responses among 50 subjects were needed to declare the treatment effective, with risk errors alpha 9% and beta 7%. RESULTS: One hundred metastatic breast cancer patients were enrolled in the study, as following: 49 in WBRT-TMZ and 51 in WBRT groups. The median age was 55 years [range, 29–79]. The median follow-up was 12 weeks [range, 1–94]. There were 15/49 (31%) partial responses (PR) in WBRT-TMZ and 18/5 1(35%) PR in WBRT group. No complete responses were observed. The symptoms relief was obtained in 27/49 and 31/51 pts, respectively. The treatment tolerance was acceptable in both groups. CONCLUSION: The benefit of adding TMZ to WBRT was not confirmed at 6 weeks. The tolerance was good in both groups. Longer follow-up is needed to evaluate the combination of TMZ with WBRT in terms of progression free survival. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-17-02.
Toxic Shock Syndrome: Relation to Catamenial Products, Personal Health and Hygiene, and Sexual Practices
Authors: Michael T. Osterholm, Jeffrey P. Davis, Robert W. Gibson, Jan C. Forfang, Susan J. Stolz, James M. Vergeront
Journal: Annals of Internal Medicine (1982)

In 1980, the discovery of an association between vaginal tampon use and toxic shock syndrome affected the lifestyles of menstruating women and the catamenial products industry. It made both the general public and the medical community more aware of all aspects of menstruation. The relation between developing toxic shock syndrome and tampon use is unclear; tampon fluid capacity (absorbency) remains the best predictive measure of that risk. No unique aspect of tampon use other than absorbency seems to increase the risk of developing toxic shock syndrome, and numerous hygiene and medical history factors do not seem to play a role in the pathogenesis of the disease. Studies in Minnesota, Wisconsin, and Iowa indicate that 70% to 75% of women between the ages of 15 and 24, the group with the highest risk of developing menstrual toxic shock syndrome, continued to use tampons after news media attention in 1980 on the association of the syndrome with tampon use. This rate of use is higher than the rate found for the general population by recent tampon market research.
Prenatal Diagnosis of Neural Tube Defects-Reply
Authors: James N. Macri
Journal: JAMA (1977)

<h3>In Reply.—</h3> It appears that the proper note has been struck in the second sentence of Dr Milunsky's letter, which acknowledges our detailing of prenatal diagnosis. In our opinion, there is a generalized deficiency in the reporting of details of diagnosis for neural tube defects in the United States. With this deficiency, the very promising use of the α-fetoprotein assay in a specific clinical protocol is becoming greatly endangered. The 1.2% false-positive diagnosis rate reported by those at the Shriver Center<sup>1</sup>is unacceptable to families who have already experienced the tragedy of having a child with a neural tube defect. The emphasis of our report and subsequent work<sup>2</sup>has always focused on a first-hand team approach to the diagnosis of neural tube defects. By using this comprehensive approach, we have now evaluated more than 150 high-risk families against a background experience of more than 3,000 pregnancies. Within this
Carcinoid Tumors of the Duodenum: Report of Three Cases Treated by Endoscopic Resection
Authors: C. Yamamoto, K. Aoyagi, H. Suekane, M. Iida, K. Hizawa, Y. Kuwano, S. Nakamura, M. Fujishima
Journal: Endoscopy (1997)

Three patients with small (less than 1 cm) duodenal carcinoid tumors are described, two of whom underwent endoscopic resection using simple snare polypectomy. In the third patient, a small tumor (5 mm) could no longer be found after initial biopsies on subsequent repeated endoscopic-bioptic follow-up. All three patients are free of local recurrence or systemic symptoms 2-14 years after the procedure.
SURGICAL TREATMENT OF CONGENITAL HYDROCEPHALUS.REPORT OF A CASE OF MENINGOCELE AND HYDROCEPHALUS.
Authors: J. SHELTON HORSLEY
Journal: JAMA (1906)

predates the fact that his method will not always prove suc- cessful, and in certain cases it may be necessary to use the suture.He reported a ease of total dislocation of the clavicle in which the man was caught between two cars going in op- posite directions.His right clavicle was totally dislocated and the left was fractured.The treatment consisted in trying to hold the bones in apposition by strapping and by applying a bandage.The treatment failed, and the dislocation recurred as fast as it could be reduced.It then occurred to the physicians to discard all the bandages, put the man in a prone po- sition, and then to use sandbags, applied, one below the elbow to keep it from sliding down, and another above, over the shoulder, at the acromion end to exert sufficient pressure to keep the clavicle in place.The head of the bed was also ele- vated.The dislocation at the inner end of the clavicle was held in place by a small sandbag, two or three inches in diameter and about a foot long, lying transverse^.The man was discharged one month after the accident, completely re- covered.According to Stimson there have been ten cases of total dislocation of the clavicle, and Dr. Cousins believes that this is the eleventh, and he would like it to go on record as such.
70 Treatment of large established subcutaneous hepatocellular carcinomas with tumor lysate pulsed dendritic cells engineered to express CD-40l induces tumor regression in mice
Authors: M.A. Gonzalez-Carmona, A. Timmerman, S. Shabani, E. Raskopf, I. Schmidt-Wolf, W.H. Caselmann, T. Sauerbruch, V. Schmitz
Journal: Journal of Hepatology (2006)
Hypertrophic cardiomyopathy in the elderly. Distinctions from the young based on cardiac shape.
Authors: H M Lever, R F Karam, P J Currie, B P Healy
Journal: Circulation (1989)

The striking clinical and pathologic features of hypertrophic cardiomyopathy have been defined almost exclusively in the young. Little is known about this condition in the elderly, although it is assumed to be part of a single disease. Accordingly, we studied 28 patients who were 65 years of age and older (mean age, 72 +/- 6.4 years) who were diagnosed as having hypertrophic cardiomyopathy by M-mode, two-dimensional, and Doppler echocardiography and compared them with a group of 28 consecutive patients with this disease who were younger than 40 years of age (mean age, 26 +/- 9.5 years). No clinically detectable differences existed between the two groups, except for an increased incidence of mild hypertension in the elderly. Echocardiography in both groups showed hypertrophy with a small left ventricular cavity, and Doppler outflow tract velocity or cardiac catheterization in most patients showed systolic anterior motion of the mitral valve or a systolic outflow tract gradient or both. Significant differences existed between both groups, however, concerning left ventricular size and shape. The elderly group had a predominantly ovoid cavity contour with normal septal curvature. In contrast, in the young group, a markedly abnormal cardiac shape predominated (p less than 0.0001) with a crescent-shaped left ventricular cavity and a reversed curvature of the interventricular septum. The right ventricular free wall was prominent by echocardiography in the young compared with the elderly group (p less than 0.001). Apart from a more frequent history of mild hypertension in the elderly, likely related to age, these findings show that hypertrophic cardiomyopathy, when present in the elderly, has similar clinical features to that in the young.(ABSTRACT TRUNCATED AT 250 WORDS)
Fertility specialists seeking better recipe for in vitro fertilization
Authors: C. A. Raymond
Journal: JAMA (1988)

ON THE HORIZON are several developments that, if widely implemented, could presage higher and more predictable birth rates at in vitro fertilization clinics. Some of those discussed at the last meeting of the American Fertility Society in Reno, Nev, included the following: • Predictors of response to follicular stimulation. Research conducted at the Jones Institute for Reproductive Medicine at the Eastern Virginia Medical School, Norfolk, suggests that women who respond to exogenous gonadotropins with a very high surge of either luteinizing hormone (LH) or folliclestimulating hormone (FSH) will not conceive. By this criterion, about 60% of women are nonresponders. These women, once identified, may avoid stimulation failure by being pretreated with gonadotropin releasing hormone (Gn-RH) agonists. • Synthetic Gn-RH agonists. Gn-RH agonists bind tightly to receptors in the pituitary gland. Initially, this stimulates the pituitary to release FSH and LH. Continuous administration, however, suppresses endogenous gonadotropin levels, through a process