Aspirin and the Transmucosal Potential Difference
Authors: ALLAN R. COOKE
Journal: Annals of Internal Medicine (1976)

Editorials1 September 1976Aspirin and the Transmucosal Potential DifferenceALLAN R. COOKE, M.D., F.A.C.P.ALLAN R. COOKE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-386 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the gastric potential difference has been known since 1834, Swyngedauw in 1928 was probably the first to record it in man. Since then it has been studied by many investigators.Measurement of transmucosal potential difference is safe and easy. An exploring and a reference electrode are made using polyethylene catheters filled with a saturated KCl-3% agar solution. The exploring electrode is placed near the surface of the mucosal layer using conventional intubation methods. The reference electrode, in vivo, is placed subcutaneously or in a peripheral vein, since there is no significant electropotential difference between the serosal surface and the...References1. GRANTHAMCODESCHLEGEL RCJ: Reference electrode sites in determination of potential difference across the gastroesophageal mucosal junction. Mayo Clin Proc 45:265-275, 1970 MedlineGoogle Scholar2. ANDERSSONGROSSMAN SM: Profile of pH, pressure, and potential difference at the gastroduodenal junction in man. Gastroenterology 49:364-371, 1965 CrossrefMedlineGoogle Scholar3. GEALLPHILLIPSSUMMERSKILL MSW: Profile of gastric potential difference in man. Gastroenterology 58:437-443, 1970 CrossrefMedlineGoogle Scholar4. MURRAYSTROTTMANCOOKE HMA: Effect of several drugs on gastric potential difference in man. Br Med J 1:19-21, 1974 CrossrefMedlineGoogle Scholar5. EDMONDSGODFREY CR: Measurement of electrical potentials of the human rectum and pelvic colon in normal and aldosterone-treated patients. Gut 11:330-337, 1970 CrossrefMedlineGoogle Scholar6. KITAHARAFOXHOGBEN SKC: Acid secretion, Na+ absorption, and the origin of the potential difference across isolated mammalian stomachs. Am J Dig Dis 14:221-238, 1969 CrossrefMedlineGoogle Scholar7. GOODMANCOLCHERKATZ EHG: The clinical significance of the electrogastrogram. Gastroenterology 29:598-608, 1955 CrossrefMedlineGoogle Scholar8. DAVENPORT H: Gastric mucosal hemorrhage in dogs. Effects of acid, aspirin and alcohol. Gastroenterology 56:439-449, 1969 CrossrefMedlineGoogle Scholar9. CHVASTACOOKE TA: The effect of several ulcerogenic drugs on the canine gastric mucosal barrier. J Lab Clin Med 79:302-315, 1972 MedlineGoogle Scholar10. COOKE A: The role of the mucosal barrier in drug induced gastric ulceration and erosions. Am J Dig Dis 21:155-164, 1976 CrossrefMedlineGoogle Scholar11. LEVY M: Aspirin use in patients with major upper gastrointestinal bleeding and peptic ulcer disease. N Engl J Med 290:1158-1162, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALLAN R. COOKE, M.D., F.A.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNon-steroidal anti-inflammatory drugs and the gastrointestinal tractMechanisms of nonsteroidal anti-inflammatory drug-induced gastric damageGastric potential difference as a model in clinical pharmacology: Assessment of gastric mucosal response to aspirinEsophageal transmural potential difference in patients with symptomatic gastroesophageal refluxThe Role of Intraluminal Junction Potentials in the Generation of the Gastric Potential Difference in Man 1 September 1976Volume 85, Issue 3Page: 386-387KeywordsAspirinCathetersIntubationVeins ePublished: 1 December 2008 Issue Published: 1 September 1976 PDF downloadLoading ...