tbuckley/cabot-search huggingface dataset:
γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes
Authors: Irma Airoldi, Alice Bertaina, Ignazia Prigione, Alessia Zorzoli, Daria Pagliara, Claudia Cocco, Raffaella Meazza, Fabrizio Loiacono, Barbarella Lucarelli, Maria Ester Bernardo, Giulia Barbarito, Daniela Pende, Alessandro Moretta, Vito Pistoia, Lorenzo Moretta, Franco Locatelli
Journal: Blood (2015)
Seasons of Aging
Authors: Lorence Gutterman
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Medical College of St. Louis.
Authors: C. Younkin
Journal: JAMA (1894)

<h3>To the Editor:</h3> —My attention has been called to an article in yourJournal, headed "<i>Stirring up the Colleges</i>," published in the issue of April 7. Will you do me the honor of correcting that which seems to me a great injustice to the American Medical College of St. Louis? Your informant, in speaking of the act of the Missouri State Board of Health, says, among other things, that the Dean of the American Medical College has been notified that this College does not conform to the requirements of the Board, and therefore its diplomas will not be recognized as entitling their possessors to practice in Missouri. I desire to say, that<i>no such notice has ever been received</i>, and that your article was the first information I had read on that subject. My attention was called to it by a private letter of inquiry from New York. This College
Why Paying for Health Care Reform Is Difficult and Essential — Numbers and Rules
Authors: Henry J. Aaron
Journal: New England Journal of Medicine (2009)

No health care reform bill can succeed unless Congress finds the money to pay for it. The challenge is brutally simple. The up-front costs of extending coverage are certain and immediate. The savings from delivery-system reform are speculative and slow. U.S. budget projections indicate explosive increases in government borrowing and rapid increases in debt-service costs, which could cause lenders to lose faith in the nation's repayment capacity. Prospects are so bleak that not even the achievement of the worthy goals of health care reform justify increasing already perilous budget deficits.1 Reform must therefore be paid for — with tax increases, . . .
Predictors of achievement in academic medicine
Authors: F. J. Papatheofanis
Journal: JAMA (1992)

<h3>In Reply.</h3> —Drs Fullilove, Fullilove, McCally, and Cassel are right to point out limitations in generalizability imposed by the composition of the cohort. Over 98% of the cohort is white; medical students of Asian ancestry account for most of the remainder. Thus, we were unable to examine predictors of achievement in racial subgroups. The cohort does include, however, 121 women who were the subject of two prior investigations regarding career choice and career achievement.<sup>1,2</sup>Of the 108 women (89%) who completed medical school and practiced medicine, 37 (34%) pursued academic careers. By 1985, seven (19%) of the academicians had achieved the rank of full professor. In comparison, male graduates were somewhat more likely to choose academic careers (45%) and much more likely to achieve the rank of professor, chairman, chief, or dean by 1990 (63%). Moreover, there were gender differences in the relationship of personal factors, such as marital
Differential Efficacy of Olanzapine for Deficit and Nondeficit Negative Symptoms in Schizophrenia
Authors: Alex Kopelowicz, Roberto Zarate, Konstantinos Tripodis, Veronica Gonzalez, Jim Mintz
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: Atypical antipsychotic medications have generally been found to be more effective than conventional antipsychotics in the treatment of negative symptoms. Whether the benefits derived from the atypical agents are the result of improvements in primary versus secondary negative symptoms is unclear. The authors examined the effects of olanzapine on primary and secondary negative symptoms for patients with severe negative symptoms who did or did not have the deficit syndrome.METHOD: Thirty-nine outpatients with schizophrenia and severe negative symptoms were assessed for the presence of the deficit syndrome and entered into a 12-week, open-label study of olanzapine. Positive and negative symptoms, extrapyramidal side effects, quality of life, and level of functioning of the patients were assessed at baseline and endpoint.RESULTS: All 39 patients completed the 12-week protocol; 13 of the patients had deficit negative symptoms, and 26 had nondeficit negative symptoms. Patients who had nondeficit negative symptoms demonstrated improvements in positive and negative symptoms, level of functioning, and extrapyramidal side effects over baseline. In contrast, patients meeting criteria for the deficit syndrome improved significantly over baseline only in extrapyramidal side effects.CONCLUSIONS: The results of this study suggest that olanzapine is efficacious for secondary negative symptoms in schizophrenia but fail to support the contention that olanzapine has a direct beneficial effect on primary negative symptoms.
VARIATION IN BLOOD TRANSFUSION PRACTICES AT THE TIME OF ACUTE MYOCARDIAL INFARCTION: AN ANALYSIS OF CONSECUTIVE PATIENTS FROM 48 U.S. HOSPITALS
Authors: Adam C. Salisbury, John Spertus, Kimberly Reid, Amit Amin, Kensey Gosch, Mikhail Kosiborod
Journal: Journal of the American College of Cardiology (2013)
Efficacy of Tracheal Gas Insufflation in Spontaneously Breathing Sheep with Lung Injury
Authors: MAURIZIO F. CEREDA, MARIA-ELENA SPARACINO, ALEXANDRA R. FRANK, RUDOLF TRAWÖGER, THEODOR KOLOBOW
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Tracheal gas insufflation (TGI) decreases dead space (V d) and can be combined with continuous positive airway pressure (CPAP) to decrease minute volume (Ve) and effort of breathing. In 11 anesthetized sheep, we induced acute lung injury (ALI) through oleic acid (OA) infusion and studied the effects of TGI combined with CPAP (CPAP-TGI) at different TGI flows and with catheters of different designs. Sheep were randomized to two groups: Group A (n = 7) was placed on CPAP and CPAP-TGI at 10 and 15 L/min of insufflation flow delivered through a reverse thrust catheter (RTC). Group B (n = 4) was placed on CPAP and CPAP-TGI at a flow of 10 L/min delivered through a RTC, and through a straight flow catheter (SFC). Compared with CPAP alone, CPAP-TGI resulted in significantly lower Vd, Ve, pressure time product, and work of breathing. We found no additional benefit from TGI flow of 15 L/min, compared with 10 L/min, and no statistically significant difference between the SFC and the RTC. In conclusion, TGI can be combined with CPAP in this model of ALI to reduce ventilation and effort of breathing.
One Commensal Bacterial Molecule — All We Need for Health?
Authors: Claudio Fiocchi
Journal: New England Journal of Medicine (2005)

Humans are not inherently endowed with a healthy immune system. The fate of the immune system depends on its interaction with a large variety of commensal microorganisms, most of which live in the lower gastrointestinal tract.1 How the body maintains homeostasis with an incredibly complex enteric microflora is beginning to be discerned. For example, it was recently shown that the recognition of commensal bacteria by epithelial cells protects against intestinal injury.2 Appropriate immune recognition of enteric bacteria is also essential to host–bacteria symbiosis, and a recent report by Mazmanian and colleagues implicates a single bacterial molecule as critical to this . . .
Long-term Evaluation of Three Multiple-Case Waldenström Macroglobulinemia Families
Authors: Mary L. McMaster, Gyorgy Csako, Therese R. Giambarresi, Linda Vasquez, Melissa Berg, Stephanie Saddlemire, Benjamin Hulley, Margaret A. Tucker
Journal: Clinical Cancer Research (2007)

Because the clinical significance of immunoglobulin abnormalities reported in relatives of familial Waldenström macroglobulinemia (WM) patients is unknown, we initiated a follow-up study of three WM families originally evaluated 27 years previously.Of 29 eligible first-degree relatives of WM patients, 27 (93%) had originally participated in clinical and electrophoretic evaluations. We re-contacted all participants for prospective follow-up electrophoretic analysis and other studies.Initially, five relatives had IgM monoclonal gammopathy (IgM MG), and four had IgM polyclonal gammopathy (PG). Twenty-two relatives (81%) were re-evaluated. Median follow-up was 17 years (range, 7-27). At re-contact, all IgM MG persisted or progressed, including three that evolved to WM. Among the four with PG, two new IgM MG cases developed. Overall, seven relatives (26%) had IgM MG, and five (18%) had IgM PG.Although based on small numbers, this study provides the longest comprehensive follow-up of WM families to date. IgM MG seems to be a phenotypic marker of WM susceptibility in some families and may have a high risk of progression to WM. IgM PG may also be important in WM families. These observations require validation in larger studies and, if confirmed, may be used to identify a cohort (relatives with IgM MG) for future prevention strategies.
It Turns Out
Authors: Ryan Childers
Journal: Annals of Internal Medicine (2014)

Ad Libitum3 June 2014It Turns OutRyan Childers, MDRyan Childers, MDFrom Portland, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0221 Audio Reading - “It Turns Out” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "It Turns Out," by R. Childers. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail You see, she never used to get like this.Vitality followed her,Loyally, from the day we met.Her accomplishmentsAs a scientist and professorA rare feat in her era,Now surpassed only by her kindness,Her tendernessAs a mother, as your grandmother,As my wife.It turns out that even she,Who had given so muchTo uncovering nature's truthsAnd had pushed so far aheadWhat we knowAbout this particular diseaseCould not predict that its strange,Yet familiar molecular danceWould play for yearsThe venues of her bodyCollecting pieces of her,Instead of applause,Always from an unsuspecting audience,Until the tipping point,Until the day it all changed.After ... Author, Article, and Disclosure InformationAffiliations: From Portland, Oregon.Current Author Address: Ryan Childers, MD; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “It Turns Out” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "It Turns Out," by R. Childers. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 3 June 2014Volume 160, Issue 11Page: 812KeywordsFallsMemoryScientists ePublished: 3 June 2014 Issue Published: 3 June 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Comportment and Health Care Reform
Authors: Phil Ball
Journal: Annals of Internal Medicine (1992)

Letters1 November 1992Comportment and Health Care ReformPhil Ball, MDPhil Ball, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-9-798_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: A national debate is going on about changing the American health delivery system. Our present medical compensation system pays much for the care of medical catastrophes and poorly for preventive care to head them off.All of us (including me) would like to be medically pampered without any personal out-of-pocket expense and (read my lips) no new taxes. Yet, we cannot afford the cost or the omissions of the medical care system as presently designed. We must consider the role of behavior and responsibility.For instance, a man who has severe emphysema but continues to smoke five... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Phil Ball, MDAffiliations: 4915 North Nebo Road Muncie, IN 47304 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1992Volume 117, Issue 9 Page: 798-798 Keywords Behavior Emphysema Health care Preventive medicine Taxes ePublished: 1 December 2008 Issue Published: 1 November 1992 PDF downloadLoading ...
Age Effects and Autopsy Evidence of Disease in Fatally Injured Drivers
Authors: Susan P. Baker, Werner U. Spitz
Journal: JAMA (1970)

A total of 328 drivers who died as the result of highway crashes was investigated, using autopsy records and police reports. There was no correlation between driver responsibility for the crash and autopsy evidence of disease or physical disability. Arteriosclerotic heart disease was found with similar frequency in drivers at fault and drivers not at fault. Several findings indicated that a decreased ability to survive crashes caused older persons to be greatly overrepresented among fatally injured drivers. The proportion of drivers who were 60 years of age or older was five times as high among those killed as among drivers who survived multivehicle crashes. Delayed death was more common among older drivers and was associated with less-serious injuries than in younger drivers.
To change your mind
Authors: L. Farrell
Journal: BMJ (1998)

I was reared as a Catholic, but long ago changed my beliefs. Heaven and hell, for instance; heaven seems nice but dull, and hell? Big black devils sticking red hot pokers up your arse for all eternity?



Attractive though it might sound, I couldn't rationalise this, and, as G K Chesterton said, there is more virtue in honest doubt than in all the blind faith in Christendom (a loophole for unbelievers everywhere).

And why should this marvellous world be only a preliminary to some hypothetical afterlife? Like most enthusiastic atheists, I have all the passion of the convert. A sky …
Ciliary neurotrophic factor receptor α subunit-modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications
Authors: Xin Hu, Yingjun Zhao, Xianghuo He, Jinjun Li, Tao Wang, Weiping Zhou, Dafang Wan, Hongyang Wang, Jianren Gu
Journal: Hepatology (2008)

Ciliary neurotrophic factor (CNTF) plays important roles in a variety of tissues including neural and non-neural systems, but the function of CNTF and its receptor (CNTFR) in liver remains unclear. In this study, we demonstrate that CNTFRα is expressed heterogeneously in normal human liver and hepatocellular carcinoma (HCC) specimens but not in hepatoblastoma specimens. We choose the CNTFRα+/CNTFRα− (CNTFRα positive/ CNTFRα negative) cell models of hepatic origin to study multiple downstream pathways of CNTFRα. We show that the presence of CNTFRα determines the temporal activation patterns of downstream signaling molecules and serves as a key modulator in regulating PI3K and AMP–activated protein kinase (AMPK) dynamically under CNTF stimulation, thus resulting in the increase of glucose uptake and translocation of glucose transporter 4 (GLUT4). Furthermore, CNTF-induced mitogen-activated protein kinase (MAPK) activation suppresses AMPK activity in the early phase of CNTF stimulation. Moreover, the protective role of CNTF against cell-cycle arrest is dependent on the presence of CNTFRα and is modulated by the glucose concentration of the culture medium. Conclusion: Our results demonstrate the importance of CNTFRα-mediated downstream signaling pathways and their functional implications in hepatic cancer cells, thus highlighting a better understanding of the biological roles of CNTFRα in human liver abnormalities, including metabolic diseases and hepatocarcinogenesis. (HEPATOLOGY 2008.)
Regulation of Apoptosis in the Prostate Gland by Androgenic Steroids
Authors: Ralph Buttyan, Ahmad Shabsigh, Harris Perlman, Marc Colombel
Journal: Trends in Endocrinology and Metabolism (1999)

The prostate gland requires androgenic steroids for its appropriate embryological formation and postpubertal growth and, once at adult size, remains dependent on a continuous supply of androgens for its vitality and function. A reduction of the levels of circulating androgens will rapidly induce apoptosis of the cells of the prostate, leading to extensive glandular regression. Studies of rodent models of prostate response to castration have shown that there are some remarkable changes in the gene activity of prostate epithelial cells leading up to apoptosis. There is now evidence for a critical cell signaling pathway, regulated by c-fos expression, necessary for castration-induced apoptosis, as well as evidence that this signaling initiates an abrupt and transient alteration in the synthesis of fas antigen, p53, bax and bcl-2 proteins in the androgen receptor-expressing prostate epithelial cells, the cellular compartment that appears to be the most affected by castration. However, more recent studies suggest that these castration-induced effects on the prostate epithelial cells might be, at least in part, an indirect response to a critical reduction in blood flow to the prostate gland that precedes the onset of epithelial cell apoptosis. The castration effects on blood flow to the prostate gland seem to be related to vascular degeneration associated with apoptosis of a subset of prostate endothelial cells.
Acquired C1-Inhibitor Deficiency Associated with Antiidiotypic Antibody to Monoclonal Immunoglobulins
Authors: Raif S. Geha, Isabella Quinti, K. Frank Austen, Marco Cicardi, Albert Sheffer, Fred S. Rosen
Journal: New England Journal of Medicine (1985)

The syndrome of acquired angioedema and C1-inhibitor deficiency is associated with B-cell lymphoproliferative disease. It is characterized by accelerated consumption of C1q and C1 inhibitor in vivo and by low levels of serum C2 and C4. Four patients with B-cell malignant diseases (IgA myeloma, macroglobulinemia, chronic lymphocytic leukemia, and B-cell lymphoma, respectively) and acquired C1-inhibitor deficiency were found to have circulating antiidiotypic antibodies to the monoclonal immunoglobulin expressed on the surface of their B cells (three patients) or in the cytoplasm of their bone-marrow cells (one patient). Two of the four patients had circulating M components, and their antiidiotypic antibodies reacted with the M components. In three patients studied the percentage of B cells bearing C1q was 18, 24, and 35 per cent, as compared with 2.3±1.7 per cent (mean±S.D.) in six normal controls. These results suggest that an interaction between the idiotype of monoclonal immunoglobulins and antiidiotypic antibodies causes increased consumption of C1q and C1 inhibitor in patients with acquired angioedema and C1-inhibitor deficiency. We propose that the subsequent activation of the early components of complement leads to increased vascular permeability and to angioedema and that these patients have a disease caused by antiidiotypic antibodies. (N Engl J Med 1985; 312:534–40.)
Plasma lipoproteins in renal transplant patients.
Authors: A J Nicholls
Journal: BMJ (1979)

adrenaline, or MA plus NMA are due to a chemical rather than to a metabolic effect of labetalol and represent falsely high values.Adequate methods should be employed in future studies evaluating the effects of labetalol on the sympathetic nervous system.Further- more, our findings may prevent errors in the differential diagnosis of phaeochromocytoma.
Estrogen modulation of left ventricular remodeling in the aged heart
Authors: Yi Xu, Ivan A Arenas, Stephen J Armstrong, Sandra T Davidge
Journal: Cardiovascular Research (2003)

Objective: To investigate the effects of estrogen on left ventricle (LV) mass and collagen deposition, and on the expression of receptors for estrogen (ERα, ERβ) and Ang II (AT2R, AT1R) in the heart of aged female rats. Methods: Aged (∼12 months old) intact (n=7), ovariectomized plus placebo (OVX, n=7), and estrogen-replaced (E2, n=6) as well as young (∼3 months old, n=4) female Sprague–Dawley rats were used in this study. After 1 month of treatment, the left ventricular weight/body weight ratio (LVW/BW), changes in myosin heavy chain expression (MHC), matrix metalloproteinase (MMP)-2 activity, the collagen I/III ratio, and the expression of ERs and Ang II receptors in the LV were evaluated. Results: In aged rats, OVX increased LVW/BW associated with a higher expression of β-MHC isoform, increased collagen I/III ratio, and decreased MMP-2 activity compared to intact rats. Furthermore, the OVX group had a decrease in ERs α and β as well as AT2R but an increase in AT1R expression. Estrogen replacement prevented the effects of ovariectomy on heart remodeling as well as increased further expression of ERβ and decreased AT1R expression. Conclusion: Removal of ovarian hormones increased LV remodeling in the aged rat, which could be attenuated by estrogen replacement. Moreover, regulation of Ang II receptor expression could be a mechanism by which estrogen may modulate heart remodeling.