tbuckley/cabot-search huggingface dataset:
Establishment of Tumor Cell Lines as an Independent Prognostic Factor for Survival Time in Patients With Small-Cell Lung Cancer
Authors: N. Masuda, M. Fukuoka, K. Matsui, Y. Kusunoki, S. Kudoh, S. Negoro, N. Takifuji, M. Fujisue, H. Morino, K. Nakagawa, M. Nishioka, M. Takada
Journal: JNCI Journal of the National Cancer Institute (1991)

We studied tumor samples from 39 patients, who entered our study from January 1989 to May 1990, to assess whether the ability to establish a continually growing tumor cell line from fresh tumor specimens can be associated with decreased survival times in patients with small-cell lung cancer. The tumor samples were used to establish cell lines in culture using a serum-free medium supplemented with hydro-cortisone, insulin, transferrin, estrogen, and selenium (HITES). Thirty-three of these specimens were obtained by fiberoptic bronchoscopy from primary sites during routine diagnostic procedures. A total of 11 (28%) cell lines were established: seven (21%) from 33 primary tumors and four (80%) from five peripheral lymph nodes. Survival times of the 11 patients whose tumor cell specimens continually grew in culture at any time during their clinical course were significantly shorter than those of the 28 patients whose tumor cell specimens did not grow in vitro (median survival time of 26 weeks versus 73 weeks; P = .0068). Cox's proportional hazards model, including sex, age, Eastern Cooperative Oncology Group performance status, stage, source of specimen, treatment, and in vitro tumor cell growth in the overall patient group, showed that cell line establishment ( P = .0017) and no therapy ( P = .0015) were the most important factors indicating poor survival time. For the subgroup of 23 primary tumor patients, the important factors (in decreasing order) that indicated decreased order) that indicated decreased survival times were the establishment of a cell line ( P = .0112) and treatment with cyclophosphamide-doxorubicin-vincristine alternating with cisplatin-etoposide, versus cisplatin-vincristine-doxorubicin-etoposide therapy ( P = .0463). Our study demonstrates that in vitro tumor cell growth is an adverse predominant prognostic factor in patients with small-cell lung cancer. [J Natl Cancer Inst 83:1743–1748, 1991]
The Statue Within: An Autobiography
Authors: A. G. Motulsky
Journal: JAMA (1988)

Scientific autobiographies often make for dull reading, since most scientists lead rather unexciting and ordinary lives of little interest to most general readers. In contrast, this book last year became a best-seller in France where Jacob grew up, worked, and won the Nobel Prize in Physiology or Medicine in 1965 for his seminal work (with Lwoff and Monod) on gene regulation. Jacob devotes more than half of the book to his childhood and young adulthood and only the last part deals with science. And it is not just about some facts of science but how science is done by its best practitioners—"a life of passion as well as of logic." Jacob is a superb writer with an elegant and graceful style. There are few scientists who will reveal the core of their personalities and then describe their emotions, strivings, hopes, and fears as felicitously and elegantly. We hear about his
Intense Vasoconstriction in Response to Aspirate From Stented Saphenous Vein Aortocoronary Bypass Grafts
Authors: Kirsten Leineweber, Dirk Böse, Magdalene Vogelsang, Michael Haude, Raimund Erbel, Gerd Heusch
Journal: Journal of the American College of Cardiology (2006)
Abstract 780: Knockdown of p53 increases tumorigenicity of human breast cancer cells.
Authors: Fang Liu, Tanima Roy, Jae Young So, Amanda Smolarek, You-Rong Lu, Nanjoo Suh
Journal: Cancer Research (2013)

Abstract The tumor suppressor p53 is mutated or functionally inactivated in ∼ 70% cancer. p53 causes cell cycle arrest, cellular senescence, or induces apoptosis in response to stress. Although knockdown of p53 has been shown to increase tumorigenicity of human colon and lung cancer cells, it is not known whether knockdown of p53 in human breast cancer cells can indeed lead to increased tumorigenicity. We show that knockdown of p53 in human breast cancer cells significantly increases tumorigenicity in vivo and colony formation on soft agar in vitro. Our ongoing studies are elucidating the underlying mechanisms. To the best of our knowledge, this is the first study demonstrating that knockdown of p53 increases tumorigenicity of human breast cancer cells. Our results highlight the importance of the tumor suppressor p53 in human breast cancer. Citation Format: Fang Liu, Tanima Roy, Jae Young So, Amanda Smolarek, You-Rong Lu, Nanjoo Suh. Knockdown of p53 increases tumorigenicity of human breast cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 780. doi:10.1158/1538-7445.AM2013-780 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
422 Efficacy and safety of adefovir for the treatment of patients with chronic hepatitis B (CHB) resistant to lamivudine in Spain
Authors: M. Buti, R. Esteban, P. Escartin, J.L. Calleja, J. Enriquez, F. Pons, J. Crespo, M.G. Bengoechea, M. Prieto, T. Casanovas, J.G. Samaniego, M. Miras, F.P. Roldan, M. Pelaez, E. Fraga, V. Moreira, P.G. Carro, M. Rueda
Journal: Journal of Hepatology (2004)
<i>Aspergillus fumigatus</i>Endocarditis
Authors: HUBERT I. CAPLAN
Journal: Annals of Internal Medicine (1968)

A case of widely disseminated, fatal, vegetative aortic endocarditis due to Aspergillus fumigatus is described. The diagnosis was established during life when a surgically removed aortic embolus revealed the organism on culture and histologic examination. A relatively short period of treatment with amphotericin B was unsuccessful. The relationship of such unusual infections to the use of antimicrobial, cytotoxic, and anti-inflammatory drugs is discussed. The importance of suspecting fungal endocarditis in view of possible curative medical and surgical treatment is emphasized.
Characterization of capacitance-free pressure-flow relations during single diastoles in dogs using an RC model with pressure-dependent parameters.
Authors: J M Canty, F J Klocke, R E Mates
Journal: Circulation Research (1987)

Although previous studies have proposed a variety of models to characterize diastolic pressure-flow relations, the models' ability to predict capacitance-free pressure-flow relations from dynamic information in individual studies has not been determined. This study tested the ability of a lumped RC model with pressure-dependent parameters to predict diastolic capacitance-free flow during maximum vasodilation in anesthetized dogs. Model parameters were characterized by perturbing the circumflex coronary artery with a ramp pressure waveform that caused coronary artery pressure to decline at rates varying from 30-150 mm Hg/sec. Capacitance-free relations constructed from declining and rising ramp pressure-flow data corresponded with capacitance-free pressure-flow points constructed during constant-pressure coronary artery perfusion (which are model-independent). The model parameters derived from analysis of the ramp data indicate that conductance of the coronary bed varies directly with coronary pressure and is independent of the rate of coronary pressure decay. Values of coronary capacitance vary inversely with coronary artery pressure and with the magnitude of dPLC/dt. Thus, a simple, lumped diastolic model with pressure-dependent parameters can predict capacitance-free pressure-flow behavior from dynamic pressure-flow data and characterize model parameters over a wide range of coronary pressure.
<i>NEJM</i>Editor Jerome P. Kassirer, MD, Loses Post Over "Administrative Issues"
Authors: Mike Mitka
Journal: JAMA (1999)

Now the nation's two top medical journals are searching for new leadership, following the July 26 decision by the Massachusetts Medical Society (MMS) not to renew the contract of Jerome P. Kassirer, MD, as editor-in-chief of the New England Journal of Medicine (NEJM).
Adult cystic fibrosis: association of acute pulmonary exacerbations and increasing severity of lung disease with auxotrophic mutants of Pseudomonas aeruginosa.
Authors: R F Taylor, M E Hodson, T L Pitt
Journal: Thorax (1993)

BACKGROUND--Pseudomonas aeruginosa has been located in the endobronchiolar spaces of patients with cystic fibrosis where nutrients may be limited. In these sites it is thought that adaptation of the pathogen might occur and growth factors, present in relative excess, may thus promote survival of the organism. Auxotrophy of pulmonary isolates of P aeruginosa has previously been shown to be a feature of cystic fibrosis and chronic lung sepsis; auxotrophic isolates have additional nutritional requirements to the prototrophic "wild types" of the species. A study was therefore carried out to determine whether the proportion of auxotrophs differs between stable and acutely ill patients, or correlates with the extent of underlying disease. METHODS--Sputum samples were cultured for P aeruginosa and tested for auxotrophy by spreading serial dilutions of homogenised sputum on to a minimal medium which supports only prototrophs, and a complete medium which supports both nutritional types. The proportion of auxotrophs to prototrophs was determined and growth factors of confirmed auxotrophs were identified. RESULTS--Thirty two (86%) of 37 adults with cystic fibrosis infected with P aeruginosa harboured auxotrophs; methionine dependent mutants were isolated from seven of 16 patients tested (44%). More than 50% of the total number of colonies were auxotrophic in 19 of 26 samples (73%) from patients with acute exacerbations and in only six of 15 samples (40%) from clinically stable patients. In four patients from whom samples in both the acute and stable states were available, the proportion of auxotrophs fell in the sample taken when stable. Auxotrophs predominated in all samples from 11 of those patients with very severe underlying lung disease, in contrast to 13 of 30 samples from patients with less severe disease. There was no association between the percentage of auxotrophs and the presence of other respiratory pathogens. CONCLUSIONS--The majority of adults with cystic fibrosis infected with P aeruginosa harbour auxotrophs in the sputum. A significant proportion of acutely ill patients and those with severe underlying disease have a preponderance of auxotrophs in the sputum compared with stable patients and those with less severe disease.
Rising cost of care in rich countries is driving patients to seek treatment in developing nations
Authors: J. Zarocostas
Journal: BMJ (2009)

“Medical tourism” is forecast to expand rapidly in the next few years, triggered by rising healthcare costs in wealthy nations, says a new report. Countries in Asia and Latin America are becoming major destinations, it says.

The report, The Rise of Medical Tourism , estimates that the global market in medical tourism will be worth $100bn (£60bn; €70bn) by 2012, up from around $60bn in 2006 and $40bn in 2004. The analysis, compiled by Grail Research LLC, a global research company, suggests that increasing medical tourism is driven in part by emerging countries investing large sums in a bid to capture a slice of this lucrative niche market.

“Contrary to some perceptions, the services provided reach beyond cosmetic procedures and include more complex, longer-term and costly care,” the report says. The …
The Adverse Effects of HIPAA on Patient Care
Authors: Deeb N. Salem, Stephen G. Pauker
Journal: New England Journal of Medicine (2003)

To the Editor: Although the goal of the Health Insurance Portability and Accountability Act of 1996 (HIPAA) is to protect patients' privacy and rights, such protections, if either misunderstood or overzealously applied, could impede necessary communication and thereby negatively affect patient care and safety. One of the explicit exemptions to the requirement that patients authorize the release of protected health information deals with the use of such information for the provision of treatment. We report two intrusions into patients' treatment resulting from misinterpretations of HIPAA. A patient between 50 and 70 years of age (exact age and sex withheld in . . .
Clinical trial of glibornuride in diabetes.
Authors: A W Logie, J M Stowers
Journal: BMJ (1975)

Glibornuride is an addition to the second-generation sulphonylureas, that has been shown in clinical trials to be effective and non-toxic. Twenty-three diabetics who were poorly controlled on other oral hypoglycaemic agents and seven newly diagnosed diabetics were treated with glibornuride. The efficacy and lack of toxicity of this drug was confirmed, but there was no evidence to suggest that it is significantly more potent than other sulphonylureas. It does not seem to represent a significant therapeutic advance.
Das Wesen der Erythrophobie
Authors: R.W. Polheim
Journal: Psychotherapy and Psychosomatics (1966)

Case Reports| February 11 2010 Das Wesen der Erythrophobie Subject Area: Psychiatry and Psychology R.W. Polheim R.W. Polheim Basel Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1966) 14 (1): 32–49. https://doi.org/10.1159/000285810 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation R.W. Polheim; Das Wesen der Erythrophobie. Psychother Psychosom 1 January 1966; 14 (1): 32–49. https://doi.org/10.1159/000285810 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Bronchodilators and acute cardiac death.
Authors: S Suissa, B Hemmelgarn, L Blais, P Ernst
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Bronchodilators used in the treatment of airway disease have been shown to have a variety of cardiac effects that may contribute to the occurrence of life-threatening events such as cardiac arrhythmias and cardiac arrest. We investigated whether theophylline and beta-agonists were associated with cardiovascular mortality among a cohort of subjects prescribed antiasthma medications. We used a population-based cohort of 12,301 subjects aged 5 to 54 yr, formed from health-insurance data bases from Saskatchewan, Canada, and spanning the period 1978 to 1987. Within this cohort, we identified all 30 deaths from cardiovascular causes in which acute asthma did not appear to be a contributing factor. We identified all asthma and cardiovascular drugs dispensed to these subjects shortly before their deaths and compared this therapy to that dispensed to a random sample of 4,080 person-time controls. After adjustment for age and the prior use of cardiac drugs, the rate of cardiovascular death was greater in users of theophylline, with a rate ratio (RR) of 2.7 (95% Cl:1.2 to 6.1), and in users of beta-agonists taken orally or by nebulizer (RR = 2.4; 95% Cl:1.0 to 5.4), but not in users of beta-agonists administered by metered-dose inhaler (RR = 1.2; 95% Cl:0.5 to 2.7). The great majority of cardiovascular deaths occurred among subjects with clinical or pathologic evidence of potentially lethal conditions. These results suggest that the use of theophylline and of beta-agonists administered orally or by nebulization should be avoided in subjects with significant cardiac disease or at high risk for such disease, especially acute coronary insufficiency and congestive cardiomyopathy. On the other hand, the use of beta-agonists administered by metered-dose inhalers (MDIs) was not associated with an increased risk of cardiovascular death.
Analysis of Tumors Arising in Male B6C3F1 Mice with and without AAV Vector Delivery to Liver
Authors: Peter Bell, A. David Moscioni, Robert J. McCarter, Di Wu, Guangping Gao, Albert Hoang, Julio C. Sanmiguel, Xun Sun, Nelson A. Wivel, Steven E. Raper, Emma E. Furth, Mark L. Batshaw, James M. Wilson
Journal: Molecular Therapy (2006)

The present study reports on the frequency of liver tumors observed in a gene therapy study with AAV vectors in male mice of the B6C3F1 hybrid background, which are known to have a high frequency of spontaneous liver tumors. Male mice with mutations in their Otc gene and their wild-type siblings received AAV vectors expressing either the murine Otc or the LacZ gene. Untreated control animals were included in the study. All experimental groups, including wild-type and OTC-deficient animals not treated with vector, developed liver nodules, which in some cases were due to hepatocellular carcinoma. Vector DNA was lower in tumors than in adjacent normal liver. A statistical analysis of the data did not show an association between treatment with Otc vectors and formation of tumors in OTC-deficient mice. However, mice treated with LacZ vectors showed increased risks of tumor formation and hepatocellular carcinoma relative to untreated animals or animals that had received vectors with Otc as the transgene. It appears that AAV vectors alone do not contribute to the formation of tumors in these strains of mice although the expression of LacZ alone or in combination with vector may be problematic.
A Review of Biostatistics: A Program of Self-instruction
Authors: William R. Barclay
Journal: JAMA (1979)

Programmed instruction is not for everyone, but for those who like this method of learning and who wish a quick and rather simple introduction to biostatistics, this small book is ideal. It is published in a ring binder and can be laid flat, turned back on itself, or slipped into a pocket. As is customary with programmed instructions, the text and interspersed questions occupy the left half of the page, and the answers appear opposite on the right half. The student keeps the answers covered and endeavors to respond to the questions correctly. The author recommends that this book be studied in a series of 20- to 30-minute sessions, which I found to be about right. One can cover a substantial part of each chapter in that time without becoming bored with this method of learning. One could finish the book in about nine sessions and thereby have a nodding
Pharmacokinetics of cefpirome in critically ill patients with renal failure treated by continuous veno-venous hemofiltration
Authors: T. S. Van der Werf, J. W. Fijen, N. C. Van de Merbel, R. Spanjersberg, A. V. M. Möller, J. J. M. Ligtenberg, J. E. Tulleken, J. G. Zijlstra, C. A. Stegeman
Journal: Intensive Care Medicine (1999)
Hypertrophic Pyloric Stenosis in the Adult
Authors: E. Medina, E. Orti, A. Tomé, A. Martinez, P. Canelles, F. Quiles
Journal: Endoscopy (1989)

In view of the low incidence of hypertrophic pyloric stenosis, we present a case of this pathology in a male aged 74. Stenosis was of the diffuse type, associated with gastric ulcer and chronic atrophic gastritis. The patient was admitted to our Service with upper digestive tract hemorrhage after deterioration of the ulcer.
The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients
Authors: Hans Dieter Nischalke, Cordula Berger, Carolin Luda, Tobias Müller, Thomas Berg, Martin Coenen, Benjamin Krämer, Christian Körner, Jonel Trebicka, Frank Grünhage, Frank Lammert, Jacob Nattermann, Tilman Sauerbruch, Ulrich Spengler
Journal: Journal of Hepatology (2011)
pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH
Authors: Dorothee H.F. Hausmann, Bei Yu, Stefan Hausmann, Kai W. Wucherpfennig
Journal: The Journal of Experimental Medicine (1999)

MHC class II molecules and invariant chain assemble at a neutral pH in the endoplasmic reticulum and are transported to a low pH compartment where the invariant chain is trimmed to the class II–associated invariant chain peptide (CLIP). For many major histocompatibility complex class II molecules, DM is required for rapid removal of CLIP, which allows binding of antigenic peptides. Since I-Ag7 confers susceptibility to type I diabetes in NOD mice, the biochemical requirements for peptide loading were examined using soluble I-Ag7 expressed in insect cells. I-Ag7 formed long-lived complexes with naturally processed peptides from transferrin and albumin, whereas several peptides that represent T cell epitopes of islet autoantigens were poor binders. I-Ag7–peptide complexes were not sodium dodecyl sulfate (SDS) resistant, indicating that SDS sensitivity may be an intrinsic property of I-Ag7. Complexes of I-Ag7 and CLIP formed at a neutral pH, but rapidly dissociated at pH 5. This rapid dissociation was due to a poor fit of M98 of CLIP in the P9 pocket of I-Ag7, since substitution of M98 by a negatively charged residue greatly enhanced the stability of the complex. These biochemical properties of I-Ag7 result in the rapid generation of empty molecules at an endosomal pH and have a global effect on peptide binding by I-Ag7.
Bedford glaucoma survey.
Authors: J. L. Bankes, E. S. Perkins, S. Tsolakis, J. E. Wright
Journal: BMJ (1968)

Numerous glaucoma surveys have been reported from North America and a few European countries since 1950, when Berens and Tolman screened 10,500 persons (see Posner and Fogland (1964) for a review of the literature up to 1962).The first survey in this country was carried out at Oxford by Luntz et al. (1963), and several other surveys are in progress (Hunt, 1966).
Less Small-Bowel Injury With Lumiracoxib Compared With Naproxen Plus Omeprazole
Authors: Christopher J. Hawkey, Christian Ell, Bernd Simon, Jörg Albert, Martin Keuchel, Mark McAlindon, Paul Fortun, Stefan Schumann, Wolfgang Bolten, Anthony Shonde, Jean–Louis Hugot, Vincent Yu, Udayasankar Arulmani, Gerhard Krammer, Rosemary Rebuli, Ervin Toth
Journal: Clinical Gastroenterology and Hepatology (2008)