tbuckley/cabot-search huggingface dataset:
Ole e 2 and Ole e 10: new clinical aspects and genetic restrictions in olive pollen allergy
Authors: J. Quiralte, E. Llanes, P. Barral, J. M. Arias de Saavedra, B. Sáenz de San Pedro, M. Villalba, J. F. Florido, R. Rodríguez, C. Lahoz, B. Cárdaba
Journal: Allergy (2005)

Background: The clinical characteristics in olive pollen allergy are dependent on the antigenic load, the allergens profile, and the genetic restrictions. Our objective was to determine specific response pattern in Ole e 2 and Ole e 10 sensitization at those levels. Methods: We studied 146 patients with seasonal rhinitis and/or asthma and positive prick test to Olea europaea pollen. IgE against Ole e 2 and Ole e 10 were detected by skin prick test and ELISA. HLA‐DRB1 and HLA‐DQB1 loci were typed by polymerase chain reaction sequence‐specific primers method. Results: A total of 102 (69.9%) and 79 (54.0%) patients showed significant IgE antibody response against Ole e 2 and Ole e 10, respectively. There was a significant association between Ole e 2 (OR 2.2, P = 0.04) and Ole e 10 reactivities (OR 2.8, P = 0.007) with asthma. In addition, total and specific IgE antibody levels significantly correlated with asthma ( P &lt; 0.05). Patients who reacted to both allergens reached the highest asthma risk factor (OR 4.3, P = 0.002). Phenotypic frequency of DR7 (OR 5.4, Pc = 0.003) and DQ2 (OR 3.6, Pc = 0.02) were increased in positive Ole e 2 patients compared with control subjects. DR2(15) phenotypic frequency was significantly increased (OR 5.6, Pc = 0.02) in positive Ole e 10 patients compared with control subjects. Conclusions: Our data suggest an association of Ole e 2 and Ole e 10 with bronchial asthma. Also, we found a genetic control of Ole e 2 and Ole e 10 IgE‐specific responses that could be relevant to clinical disease in olive pollen allergy.
The variability of regional airflow obstruction within the lungs of patients with asthma: Assessment with hyperpolarized helium-3 magnetic resonance imaging
Authors: Eduard E. de Lange, Talissa A. Altes, James T. Patrie, Jaywant Parmar, James R. Brookeman, John P. Mugler, Thomas A.E. Platts-Mills
Journal: Journal of Allergy and Clinical Immunology (2007)
Royal Medical and Chirurgical Society: Tuesday, April 29, 1841
Authors: None Williams
Journal: BMJ (1841)

NERVOUS DISEASES.EPIDEMICS.life, before he is to be considered as a fitting object for public commiseration, is fraught with mis- chief, which, in a time of general distress, will recoil on those who are the contrivers of it.Des- titution on the great scale, whether mediately through its depressing influence on the mind, or immediately by its direct agency in debilitating the powers of the body, is invariably followed by pestilence, which, while it devastates the poor man's dwelling, rarely allows the habitation of the rich to pass unscathed.A heavy responsibility, therefore, attaches to those who, in their plans of economy, and professing zeal for saving the public purse, are the advocates of measures which make absolute destitution the only plea for relief.
Drinking Frequency, Mediating Biomarkers, and Risk of Myocardial Infarction in Women and Men
Authors: Kenneth J. Mukamal, Majken K. Jensen, Morten Grønbæk, Meir J. Stampfer, JoAnn E. Manson, Tobias Pischon, Eric B. Rimm
Journal: Circulation (2005)

The associations of drinking frequency and quantity with risk of myocardial infarction have not been studied among women, and the degree to which specific risk factors mediate the inverse association of drinking frequency with risk of myocardial infarction is uncertain.We conducted nested case-control studies of 32,826 women enrolled in the Nurses Health Study followed up from 1990 to 1998 and 18,225 men enrolled in the Health Professionals Follow-Up Study followed up from 1994 to 2000. A total of 249 women and 266 men with incident myocardial infarction were matched on age, smoking, and date of entry to 498 female and 532 male control participants. We determined the risk of myocardial infarction related to frequency and quantity of alcohol intake and the change in risk before and after adjustment for putative cardiovascular risk factors. Among both women and men, drinking frequency tended to be associated with lower risk of myocardial infarction, with the lowest risks among those who drank 3 to 7 days per week. Further adjustment for levels of high-density lipoprotein cholesterol, hemoglobin A(1c), and fibrinogen attenuated 75% of the association of frequent drinking with risk among women and fully attenuated the association among men.Alcohol intake at least 3 to 4 days per week is associated with a lower risk of myocardial infarction among women and men, an association apparently attributable to the relationship of alcohol with HDL cholesterol, fibrinogen, and hemoglobin A(1c). Because the effects of alcohol on HDL cholesterol, fibrinogen, and insulin sensitivity have been confirmed in randomized trials, our findings support the hypothesis that the inverse relation of alcohol use and myocardial infarction is causal.
Combined Papillary and Mucoepidermoid Carcinoma of the Thyroid Gland: a Possible Collision Tumor Diagnosed on Fine-Needle Cytology. Report of a Case with Immunocytochemical and Molecular Correlations
Authors: Franco Fulciniti, Emilia Vuttariello, Celeste Calise, Mario Monaco, Luciano Pezzullo, Maria Grazia Chiofalo, Francesca Di Gennaro, Maria Gabriella Malzone, Anna Cipolletta Campanile, Nunzia Simona Losito, Gerardo Botti, Gennaro Chiappetta
Journal: Endocrine Pathology (2015)
811-4 Coronary Doppler Flow Velocity and PET Myocardial Blood Flow are Highly Correlated and Predict Post-Infarction Perfusion In Patients with TIMI 3 Flow
Authors: Richard E. Stewart, Terry R. Bowers, Richard Ponto, D. Douglas Miller, William W. O’Neill, Cindy L. Grines, Robert D. Salian, Jack E. Juni
Journal: Journal of the American College of Cardiology (1995)
Editorial: Efects of high altitude on the eyes
Authors: H. H. Hussey
Journal: JAMA (1975)

The current issue of<i>Archives of Ophthalmology</i>publishes a trio of articles that deal with the effects of high altitude on the ocular system and brain. All three reports emphasize the prevalence of high-altitude retinal hemorrhages that disappear after return to low altitudes. Rennie and Morissey (93:395-400, 1975) had the opportunity to study the American expedition to Dhaulagiri (8,167 meters [26,795 ft]), a mountain in the Central Himalayas, the sixth highest mountain in the world and the highest ever climbed without the use of supplemental oxygen. The expedition included 15 experienced American climbers, all of whom were physically fit, and five Nepali Sherpas. Retinal photographs had been taken at sea level before the start of the climb and were repeated at high altitude after the climbers had undertaken quite strenuous exertion. All of the American climbers manifested ocular changes including vascular engorgement and tortuosity, plus retinal hemorrhages in five instances.
REFLEX NEUROSES DUE TO MORBID THROAT CONDITIONS.
Authors: ROSS ALLEN HARRIS
Journal: JAMA (1907)

The subject of this paper was suggested by a number of recent cases, each of which exhibited some unusual manifestation of local cause with distant neurotic effect. These cases, while appealing most strongly to the specialist, may perhaps emphasize to the general physician the importance of associating remote asthenic consequence with a true organic origin. <h3>Case 1.</h3> —Hysterical cough. Physician, aged 44, of French and Spanish parentage. His family history is practically negative. <h3>History.</h3> —For two weeks the patient had been annoyed by a dry, irritable cough, with some expectoration of white mucus; most troublesome at night or on lying down There was a sensation of a foreign body in the throat; which the patient located below the really affected area. Latterly the cough had been so persistent that he was unable to eat, sleep or attend to his office practice. His chief worry was lest the condition be one
Ether and Chloroform.
Authors: E. Chenery
Journal: JAMA (1897)

Boston, Mass., Jan. 6, 1897. <h3>To the Editor:</h3> —Considerable has been written on the comparative use and danger of ether and chloroform. Only a few weeks ago I saw an article in which was the statement that a number of deaths by chloroform had occurred in women in confinement. Not many months ago I also saw it stated that no such case is on record. Now, which of these writers is correct? Has chloroform killed any woman under such circumstances? I, for one, have no remembrance of seeing such an instance reported. If both ether and chloroform cause death in such cases we must then select accordingly. There are several points, however, we may properly consider as between the two. 1. Help: An etherized patient, unless thoroughly under its influence, must be regarded as drunk or crazy, requiring considerable assistance to control and take care of her. It is not
Salt and the glycaemic response.
Authors: A W Thorburn, J C Brand, A S Truswell
Journal: BMJ (1986)

The possibility that salt increases plasma glucose and insulin responses to starchy foods was investigated. Six healthy adults took four morning test meals randomly: 50 g carbohydrate as cooked lentils or white bread, with or without 4.25 g of added salt (an amount within the range of salt found in a meal). When salt was added to the lentils the incremental area under the three hour plasma glucose curve was significantly greater than that for lentils alone (43.2 mmol.min/l v 11.1 mmol.min/l (778 mg.min/100 ml v 200 mg.min/100 ml]. When salt was added to bread the peak glucose concentration was significantly higher than that for unsalted bread (6.96 mmol/l v 6.35 mmol/l (125 mg/100 ml v 114 mg/100 ml], and this was followed by relative hypoglycaemia. Plasma insulin concentrations at 45 minutes were higher after a meal of salted lentils and salted bread than after the unsalted foods (p less than 0.05). The high insulin concentration after salted bread was sustained for one hour after the meal, thus the mean area under the three hour curve was 39% greater than that for unsalted bread (p less than 0.05). Salt may increase the postprandial plasma glucose and insulin responses to lentils and bread by accelerating the digestion of starch by stimulating amylase activity or accelerating small intestinal absorption of the liberated glucose, or both. The findings of this preliminary study, if confirmed by others, would support the recommendation that diabetics, as well as the general population, should reduce their intake of salt.
Visceral Leishmaniasis
Authors: Sydney P. Waud, Sam Kruger
Journal: New England Journal of Medicine (1947)

VISCERAL leishmaniasis (kala-azar) in American personnel returning to the United States has been rare. Burchenal and Woods§ reported 3 cases in American troops who had contracted the disease in the Mediterranean area. It is estimated that approximately 60 cases of the disease have occurred in American troops during World War II, the majority of which were contracted in the India-Burma Theater. The endemic areas where American personnel have been stationed are India, North Africa, Sicily, Southern Italy, Manchuria and China.Visceral leishmaniasis is an infective disease that is characterized by fever, splenomegaly and usually hepatomegaly, as well as by a . . .
Investigations of the simian ontogenic switch from fetal to adult hemoglobin at the progenitor cell level.
Authors: B P Alter, R S Weinberg, D C Linch, J M Schofield, B T Jackson, G J Piasecki, J C Thornton, D G Nathan
Journal: Journal of Clinical Investigation (1986)

The ontogenic switch from fetal to adult hemoglobin could result from discontinuous events, such as replacement of fetal erythroid progenitor cells by adult ones, or gradual modulation of the hemoglobin program of a single progenitor cell pool. The former would result in progenitors at midswitch with skewed fractional beta-globin synthesis programs, the latter in a Gaussian distribution. For these studies, we obtained bone marrow from rhesus monkey fetuses at 141-153 d (midswitch). Mononuclear cells were cultured in methyl cellulose with erythropoietin, and single BFU-E-derived colonies were removed and incubated with [3H]leucine. Globin synthesis was examined by gel electrophoresis and fluorography. The beta-globin synthesis pattern of single fetal colonies was skewed, and did not fit a normal distribution. The fetal pattern resembled the pattern of an artificial mixture of fetal and adult progenitors, suggesting that the fetal progenitor pool could contain populations with different beta-globin programs. This non-Gaussian distribution in the progenitors of midswitch fetuses is consistent with a discontinuous model for hemoglobin switching during ontogeny.
The IPSO study: ibuprofen, paracetamol study in osteoarthritis. A randomised comparative clinical study comparing the efficacy and safety of ibuprofen and paracetamol analgesic treatment of osteoarthritis of the knee or hip
Authors: F Boureau, H Schneid, N Zeghari, R Wall, P Bourgeois
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objective:</b> To compare the analgesic efficacy of single and multiple doses of ibuprofen with that of paracetamol in patients with knee or hip osteoarthritis (IPSO study). <b>Method:</b> 222 patients were randomised in a double blind, multicentre study—156 (70%) had a painful knee joint and 66 (30%) a painful hip joint. The main efficacy criterion was pain intensity assessment after a single dose (ibuprofen 400 mg, paracetamol 1000 mg). Functional disability assessment and patient global assessment were carried out over 14 days. <b>Results:</b> The sum of the pain intensity difference over 6 hours after the first administration was significantly higher (p = 0.046) in the ibuprofen group than in the paracetamol group. Over 14 days pain intensity decreased from the first day and was significantly lower in the ibuprofen group than in the paracetamol group (p&lt;0.05). The functional disability of the patient was assessed using the WOMAC; the ibuprofen group improved significantly over 2 weeks compared with the paracetamol group for each of the subscales: stiffness (p&lt;0.002), pain (p&lt;0.001), physical function (p&lt;0.002). The drugs were equally safe. <b>Conclusion:</b> The IPSO study shows that for the treatment of osteoarthritic pain, ibuprofen 400 mg at a single and multiple dose (1200 mg/day) for 14 days is more effective than paracetamol, either as a single dose of 1000 mg or a multiple dose (3000 mg/day). Because ibuprofen and paracetamol have similar tolerability, this study indicates that the efficacy/tolerability ratio of ibuprofen is better than that of paracetamol in this indication over 14 days.
Quantitative Skeletal Histology in Untreated End-stage Renal Failure
Authors: J. P. Ingham, J. H. Stewart, S. Posen
Journal: BMJ (1973)

Forty-six patients with end-stage renal failure were subjected to iliac crest biopsy before the initiation of a dialysis programme and regardless of the presence of skeletal symptoms. Quantitative studies of undecalcified sections showed osteoporosis in 11 patients, osteosclerosis in 10, and osteomalacia (alone or in combination with other lesions) in 14. Semiquantitative studies showed osteitis fibrosa (alone or in combination with other lesions) in 29. The various abnormalities occurred alone or in combination with one another and, to a large extent, independently of serum biochemistry.Radiological examination failed to diagnose the histological abnormality in 12 of 13 patients with osteomalacia and in 10 of 25 patients with osteitis fibrosa. These abnormalities were commoner in women, in patients with pyelonephritis, and in patients with documented renal failure of long standing. Bone volume changes could not be correlated with any clinical parameters.Skeletal findings in untreated patients should be taken into account when the effects of chronic dialysis or renal transplantation or both are being considered.
Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease
Authors: Bin Xiao, Yu Wang, Wei Li, Megan Baker, Jian Guo, Kelly Corbet, Ephraim L. Tsalik, Qi-Jing Li, Scott M. Palmer, Christopher W. Woods, Zhiguo Li, Nelson J. Chao, You-Wen He
Journal: Blood (2013)
Friends and family test "unfit" for comparing NHS services, finds research
Authors: Z. Kmietowicz
Journal: BMJ (2014)

The friends and family test has been branded “unreliable” and “not fit for purpose” because the information it collects cannot be used to compare services across the NHS in England, a new study concludes.1

The research, conducted by the Picker Institute Europe, did find, however, that the test, in which patients are asked whether they would recommend a service to family and friends, can be used to drive improvements in services. The institute is a not for profit organisation that measures patients’ experiences.

The friends and family test was introduced by the UK prime minister, David Cameron, in 2012 and was rolled …
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
Authors: Abdel Kareem Azab, Jinsong Hu, Phong Quang, Feda Azab, Costas Pitsillides, Rana Awwad, Brian Thompson, Patricia Maiso, Jessica D. Sun, Charles P. Hart, Aldo M. Roccaro, Antonio Sacco, Hai T. Ngo, Charles P. Lin, Andrew L. Kung, Ruben D. Carrasco, Karin Vanderkerken, Irene M. Ghobrial
Journal: Blood (2012)
US agency limits payments for anaemia drugs
Authors: Jeanne Lenzer
Journal: BMJ (2007)

The US Centers for Medicare and Medicaid Services has issued a proposal to limit Medicare payments for anaemia drugs used to treat patients with cancer.

The proposal came on the heels of new warnings from the oncology drugs committee of the US Food and Drug Administration that the drugs, known as erythropoiesis stimulating agents (ESAs) are overused and could shorten patients' lives.

The committee unanimously recommended new clinical trials of the drugs, including Aranesp (darbepoetin alfa) and Epogen (epoetin alfa), made by Amgen, and Procrit (epoetin alfa), made by Johnson and Johnson ( BMJ 2007;334:1022, 19 May doi: 10.1136/bmj.39216.489780.DB).

The FDA issued updated public health advise on …
An Epidemiologic Study of Risk Factors in Two Teenage Suicide Clusters
Authors: Lucy E. Davidson
Journal: JAMA (1989)

Two clusters of teenage suicides occurred in Texas between February 1983 and October 1984. The eight suicides from the first cluster and the six from the second were investigated together in a case-control study using a closed-response questionnaire administered to parents. Three control teenagers were matched with each case subject on the basis of school district, grade, race, and sex. Questions concerned the direct and indirect exposures of subjects to previous suicides as well as their life circumstances and behaviors. Case subjects were not more likely than control subjects to have had direct exposure to suicide as measured by their acquaintance with a person who committed suicide. Similarly, indirect exposure to suicide through the media was not associated significantly with suicide. Case subjects were more likely to have attempted or threatened suicide previously, to have damaged themselves physically, and to have known someone closely who died violently. Case subjects were more likely to have broken up with their girlfriends or boyfriends recently. They also had moved more often than control subjects, attended more schools, and lived with more parent figures. Identification of high-risk youths through knowledge of relevant risk factors can help to direct preventive services to those young people most susceptible to suicide.
Qualification and the year as a preregistration house officer.
Authors: P Richards
Journal: BMJ (1983)

This case illustrates an oculoischaemic syndrome presenting with iris neovascularisation in a patient with established diabetic retinopathy. It highlights the importance of considering the differential diagnosis of rubeosis in all patients, including those with an underlying vascular pathology. Moreover, it urges clinicians to consider the sequelae of a compromised vascular system, such as the iatrogenic central retinal artery occlusion as a result of intravitreal injections. Early diagnosis not only informs correct ophthalmic treatment, but is crucial in preventing ischaemic stroke and, therefore, reducing the risk of systemic morbidity and mortality.
Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia
Authors: Ashley M. Toye, Sandip Ghosh, Mark T. Young, Graham K. Jones, Richard B. Sessions, Martine Ramaugé, Philippe Leclerc, Joyoti Basu, Jean Delaunay, Michael J. A. Tanner
Journal: Blood (2005)
Cutting Both Ways: On the Ethical Entanglements of Human Rights, Rites, and Genital Mutilation
Authors: Sarah Burgess, Stuart J. Murray
Journal: The American Journal of Bioethics (2015)

The title of Allan J. Jacobs and Kavita Shah Arora's essay, “Ritual Male Infant Circumcision and Human Rights” (2015), reflects the conjunction and, we argue, the conflation of rites and rights fou...
Stepping Down Therapy in COPD
Authors: John J. Reilly
Journal: New England Journal of Medicine (2014)

Patients with symptomatic chronic obstructive pulmonary disease (COPD) are commonly treated with inhaled medications that fall into three classes: beta-agonists, muscarinic antagonists, and glucocorticoids. Most patients with moderate-to-severe COPD are receiving one or more inhaled agents; inhaled glucocorticoids and inhaled long-acting beta-agonists (LABAs) are more commonly used than are long-acting muscarinic antagonists (LAMAs).13 However, the track record for inhaled medications in COPD is mixed. All three classes of drugs produce modest improvements in airflow obstruction, provide symptomatic benefit, and reduce the rate of COPD exacerbations.1,2,4,5 But they do not appear to alter the rate of the . . .
Activity of Levofloxacin, Ofloxacin, D-Ofloxacin and Ciprofloxacin against Systemic and Respiratory Tract Infections in Laboratory Animals
Authors: N. Klesel, K.-H. Geweniger, P. Koletzki, D. Isert, M. Limbert, A. Markus, G. Riess, H. Schramm, G. Seibert, P. Iyer, A. Bryskier
Journal: Drugs (1995)
Comprehensive Department of Psychological Medicine: Three-year Review of Inpatients Referred for Aftercare Visits
Authors: M. Silverman
Journal: BMJ (1971)

All inpatients discharged in 1967 from a comprehensive department of psychological medicine who were referred for aftercare visiting by a mental welfare officer or psychiatric social worker were reviewed after a period of three years. Over this period half the patients had not been readmitted and only 6.3% of those below retirement age had been unemployed for 75% or more of the total time involved. Altogether 76% were assessed as socially integrated, though there had been a drift away from living at home.It is probable that case conferences made the process of referral for aftercare more discriminating and that the follow up conferences contributed substantially towards the care, supervision, and maintenance of these patients in the community. Measures of this kind are essential if a general hospital psychiatric service is intended to cope with the total problem involved.
Alteractions of germ cells leading to mutagenesis and their detection
Authors: David J. Brusick
Journal: Environmental Health Perspectives (1978)

Germ cell risk is an essential component of estimating the deleterious results of environmental mutagens. The present set of in vivo model systems appears to have limited ability to measure germ cell risk from all types of genetic lesions. The assays most practical for use in genetic testing measure the induction of chromosome alterations but not specific locus gene mutations. Quantitative estimation of germ cell risk based on such available assays is difficult to make and may lead to incorrect assumptions of risk. Better assessment of germ cell genetic damage will require expansion of present procedures to increase sensitivity and the development of improved assay systems.