tbuckley/cabot-search huggingface dataset:
Mechanical left atrial appendage closure was noninferior and superior to warfarin in atrial fibrillation
Authors: Vinai Bhagirath, Jacqueline Bosch, John Eikelboom
Journal: Annals of Internal Medicine (2015)

Source Citation Reddy VY, Sievert H, Halperin J, et al; PROTECT AF Steering Committee and Investigators. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA. 2014;312:1988-98. 25399274
ANTI-TUBERCLE SERUM.THE TREATMENT OF CONSUMPTION BY SEROTHERAPY— REPORT AND PRESENTATION OF CASES TREATED— EXHIBITION OF SERUM, ETC.
Authors: PAUL PAQUIN
Journal: JAMA (1895)

<h3>Preliminary Remarks.</h3> —It would seem superfluous to say a word here on the pathology of this affection. But the nature of the new treatment demands that we refresh our memory on some points of it before certain therapeutic questions to be dealt with presently may appear clear. The result of my observations and researches have convinced me beyond a doubt that tuberculosis, in the stage of lesions, particularly when pulmonary cavities, intestinal ulcers, etc., exist becomes a mixed infection, due to the introduction of various other pathogenic microbes besides the bacillus of tuberculosis in the specific wound. Myriads of germs of the air, water and food gain access to tuberculous lesions and complicate the primary disease to a very grave degree. The destruction of tissue by these germs, the production of new mixed poisons, perhaps more dangerous sometimes because of chemic combinations, are largely responsible for the irregular chills, fevers
Fibronectin and C4-binding protein are selectively bound by aggregated amyloid P component
Authors: FC DeBeer, ML Baltz, S Holford, A Feinstein, MB Pepys
Journal: The Journal of Experimental Medicine (1981)

Serum amyloid P component (SAP) is a normal plasma protein, closely related to C-reactive protein, which is deposited together with amyloid fibrils in all forms of amyloidosis. It is also a normal constituent of human tissues, where it is found in vascular basement membranes and in association with the peripheral microfibrillar mantle of elastic fibres throughout the body. Very similar, highly conserved, homologous proteins are present in the sera of all vertebrates in which they have been sought, and in all cases these proteins display calcium-dependent binding affinity for agarose. The physiological function or pathogenetic significance of this reactivity are not known but we report here for the first time that under appropriate conditions human SAP can also bind certain serum glycoproteins. SAP, which had been aggregated either by direct conjugation to CNBr-activated Sepharose beads, or by complexing with anti-SAP antibodies immobilized on such beads, selectively took up fibronectin and C4-binding protein from whole normal human serum. The reaction was calcium dependent and the two ligands were bound independently of each other or of other serum constituents. Experiments with isolated fibronectin and SAP complexed by anti-SAP-Sepharose indicated that close association of pairs of SAP molecules was required for fibronectin to be bound and that each SAP dimer was capable of taking up a single molecule of fibronectin. There was no evidence that SAP in its native state in the serum was complexed with either fibronectin or C4-binding protein. The present findings significantly extend knowledge of the properties of SAP and open the way to characterisation of its physiological ligand(s) and thence to elucidation of its function.
Infarction and Coronary Insufficiency During Electroconvulsive Therapy
Authors: Allen E. Hussar
Journal: JAMA (1968)

To the Editor:—  In answer to the questions of Drs. Mazzia and Dell'-Aria, the last daily digitalis maintenance dose was given 24 hours before shock treatment. The patient received ventilation with a bagvalve-mask ventilator, using room air, immediately before and immediately after shock was given. There was no period of apnea. The patient breathed spontaneously and well when he was taken to the recovery room for continued observation. There, a few minutes later, he suddenly died. Unfortunately, besides apnea and blood gas changes, our article listed several other factors which exerted strain upon the heart during convulsive therapy.
Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection
Authors: Hitokazu Esaki, David A Ewald, Benjamin Ungar, Mariya Rozenblit, Xiuzhong Zheng, Hui Xu, Yeriel D Estrada, Xiangyu Peng, Hiroshi Mitsui, Thomas Litman, Mayte Suárez-Fariñas, James G Krueger, Emma Guttman-Yassky
Journal: Journal of Allergy and Clinical Immunology (2015)
Map of the Human Heart
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How family friendly is the UK?
Authors: W. Caan
Journal: BMJ (2011)

The UK is lagging behind the rest of the EU on several measures of family wellbeing

Before becoming prime minister, David Cameron promised voters he had a “long term vision of making Britain the most family friendly country in the world,” and now The Family Pressure Gauge, published in May 2011, is an attempt by the Relationships Foundation to measure Cameron’s annual progress in “helping families with the pressures they face.”1 This pressure gauge compares official data from the United Kingdom with other European countries. Overall, Britain is judged a bad place to be a child (table⇓).1

View this table:

Areas where the UK falls far behind the best other European countries1



Policies that promote a secure family home, a safe school environment, parents’ escape from poverty, and inclusion in local social networks contribute towards maximising the potential wellbeing of every child.2 Unfortunately for population health and wellbeing, millions of British children do not experience such positive environments. In 2007, a Unicef report showed that life was miserable for more schoolchildren in the UK than in other “economically advanced” nations.3 It took a while for the Department of Health fully to grasp the implications of this widespread family misery, but a 2011 strategy prioritised the prevention of mental illness and early intervention for childhood problems.4 The strategy also committed the Department of Health to work alongside the Office for National Statistics in developing better measures of wellbeing and the Office for Civil Society in linking social policy more directly …
The Cost-effectiveness of Misoprostol
Authors: Alan L. Hillman
Journal: JAMA (1991)

To the Editor.—  We commend Edelson et al 1 on a thoughtful economic analysis of misoprostol, parts of which extend and corroborate our earlier work. 2 We agree that the most robust science is produced when different investigators approach a question in different ways and come to similar conclusions, which is indeed the case with portions of our two studies. 3   There is one published, randomized, controlled clinical trial of misoprostol for prophylaxis of gastric ulcer, in which all patients had multiple endoscopies. 4 In this 3-month trial, all of the several hundred patients with osteoarthritis had abdominal pain attributed to use of nonsteroidal anti-inflammatory drugs (NSAIDs) (but no gastric ulcer on endoscopy on entry to the study). The statements of Edelson et al about our interpretation of these data are incorrect. We calculated the relative risk of gastric ulcer in patients receiving misoprostol compared with the control group to
Edward Gibbon's health.
Authors: W D Foster
Journal: BMJ (1979)

fierce, we used to go down to the morgue (which is just back of imy ward) anid look at the boys laid out in long rows.It beats any sight they ever had in Fralnce after a battle.An extra long barracks has been vacated for the use of the Morgue, anid it would imiake any imlain sit up and take notice to walk down the long lines of dead soldiers all dressed and laid out in double rows.We have no relief here, you get up in the miorninig at 5.30 and work steady till about 9.30 P.M., sleep, then go at it againi.Somiie of the ImienI of course have been here all the time, and they are TIRED.
Proportions of immature CD19+CD21− B lymphocytes predict the response to extracorporeal photopheresis in patients with chronic graft-versus-host disease
Authors: Zoya Kuzmina, Hildegard T. Greinix, Robert Knobler, Nina Worel, Michal Kouba, Roman Weigl, Ulrike Körmöczi, Arno Rottal, David Pohlreich, Christoph Zielinski, Winfried F. Pickl
Journal: Blood (2009)
Emotional Conflicts in the Resident
Authors: JON D. HODGIN
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 September 1982Emotional Conflicts in the ResidentJON D. HODGIN, M.D.JON D. HODGIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-3-456_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read the recent article by Lichstein (1) with great interest. The subject of emotions generated along the patient-physician interface is of importance not only in internal medicine and psychiatry, but to all medical specialties. I feel, however, that some additional points need to be discussed.Dr. Lichstein correctly notes that a resident who has a certain level of awareness will be able to identify those patient behaviors that arise from unexpressed emotions, mainly anxiety, felt toward the physician. This task, however, requires the ability and the time to step back from the situation to identify the...Reference1. LICHSTEIN P. The resident leaves the patient: another look at the doctor-patient relationship. Ann Intern Med. 1982;96 (6 Pt 1):762-5. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JON D. HODGIN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1982Volume 97, Issue 3Page: 456-456KeywordsAnxietyBehaviorEmotions ePublished: 1 December 2008 Issue Published: 1 September 1982 PDF downloadLoading ...
Excision of fascia in melanoma thicker than 2 mm: no evidence for improved clinical outcome
Authors: R.E. Hunger, S.M. Seyed Jafari, S. Angermeier, M. Shafighi
Journal: British Journal of Dermatology (2014)

Background Lack of evidence-based data causes significant variation among surgeons concerning the depth of wide excision for primary cutaneous melanomas. Objectives To evaluate the clinical effect of excision of the deep fascia in melanomas thicker than 2 mm on patient outcome. Methods We performed a retrospective cohort review (1996–2012) of patients with melanomas thicker than 2 mm. Included patients underwent excision with a 1-cm margin. Data collected included the patients' sex, age, tumour location, tumour type, Breslow depth and presence of ulceration. Local recurrences, locoregional and distant metastases, and disease-free and overall survival were compared between the fascia-excised and the fascia-preserved groups. Results Out of 2182 patients with malignant melanomas, 213 melanomas thicker than 2 mm, with a median follow-up of 1547 days, were included. The mean age of the patients was 62·6 years and the mean Breslow depth was 4·2 mm. Analysis of data for death attributable to melanoma (P = 0·72), local recurrence (P = 0·71), and locoregional (P = 0·87) and distant metastases (P = 0·34) were not significantly different between the study groups. Furthermore, Kaplan–Meier and Cox regression analysis of both groups showed no evidence of significant difference regarding disease-free [P = 0·35; hazard ratio (HR) 1·25; 95% confidence interval (CI) 0·79–1·97] and overall survival (P = 0·63; HR 1·18; 95% CI 0·61–2·27). Conclusions We believe that excision of the deep fascia does not improve the outcome of melanomas thicker than 2 mm.
Influence of anti-HLA antibodies and positive T-lymphocytotoxic crossmatch on survival and graft rejection in human liver transplantation
Authors: Ramón Charco, Victor Vargas, Joaquim Balsells, Jose Luis Lázaro, Enrique Murio, Eduardo Jaurrieta, Jaime Martorell, Carlos Margarit
Journal: Journal of Hepatology (1996)
Shortening the Medical School Curriculum
Authors: Warren H. Gullen
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Suggestions that the medical school curriculum should be shortened (eg, from four years to three years) include variants such as contracting the traditional two years of basic science into one year, transferring the freshman medical school year to the premedical curriculum, and the like. Not having seen the following statement published, I shall belabor the obvious and point out that, barring other concomitant changes such as increasing the size of each medical school class, the increase in the number of physicians produced by reducing the medical school course from four years to three would be a one-time bonus equal to one year's class and would not be recurrent. A reduction in course length may be advantageous to the student and it may make medicine more attractive as a profession. Lack of attractiveness as a profession is not a factor in the overall "shortage" of physicians, however, since
PD5-1-3: What effects do anatomic changes during treatment have on target and normal tissue dosimetry parameters of lung cancer radiotherapy? A multiple 4DCT analysis
Authors: Keith R. Britton, George Starkschall, Helen Liu, Joe Y. Chang, Michael Kantor, James D. Cox, Radhe Mohan, Ritsuko Komaki
Journal: Journal of Thoracic Oncology (2007)
Functional capacities of T lymphocyte subsets from synovial fluid and blood in rheumatoid arthritis.
Authors: J Petersen
Journal: Annals of the Rheumatic Diseases (1986)

A reverse haemolytic plaque forming cell (PFC) assay was employed to analyse the impact of T suppressor/cytotoxic and T helper cells on B cell function in 10 patients with rheumatoid arthritis (RA). In all cases T8-enriched cells from synovial fluid and blood suppressed the pokeweed mitogen (PWM) induced IgM, IgG, and IgA secretion by autologous lymphocytes to the same degree. The suppression was partly abolished by irradiation of T8-enriched cells. T4-enriched cells from blood increased the PWM induced Ig secretion by autologous blood B cells. In six of 10 patients responses 1.2 to four times higher were obtained with T4-enriched cells from synovial fluid, but in four of 10 patients synovial fluid T4-enriched cells did not increase the PWM responses of blood B cells. T4- and T8-enriched T cells from synovial fluid comprised more Ia+ cells than did T cells from blood (36% v 3% and 43% v 6%). Ia+ T helper and suppressor/cytotoxic cells may modulate in vivo activation of synovial B cells in RA.
PWE-099 Faecal Calprotectin: Help or Hinderance in Evaluating Patients with Lower GI Symptoms: Abstract PWE-099 Table
Authors: M Allison, M Hu, S Puritz, T Richards, N El-Farhan
Journal: Gut (2013)

<h3>Introduction</h3> Several studies demonstrate the potential of faecal calprotectin measurement in distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS). It is unclear, however, to what extent such measurements alter patient investigation and management over standard history taking, examination and routine blood tests. <h3>Methods</h3> We reviewed all faecal calprotectin results from samples submitted by adults not previously known to have IBD between February 2010 and April 2012. Using the health board’s Clinical Workstation relevant outpatient letters, results of subsequent investigations and clinical outcomes were reviewed. A calprotectin value of &gt; 60ug/g was considered elevated. <h3>Results</h3> Cinical data was missing for 13 of the 266 patients. Of 155 with a normal result management was unaltered in 126, of whom 50 were referred for lower GI endoscopy before their result was known. In another 5 patients IBD was later found despite a normal result. A normal result may have obviated the need for colonoscopy or capsule endoscopy in 17, and otherwise altered management in 12 other patients. Outcomes for the 98 with an elevated result are summarised in the table. Patient management was unaltered in 60. There were 33 for whom an elevated result prompted colonoscopy and/or capsule endoscopy, and results were normal in 27. Five others still await colonoscopy or capsule. <h3>Conclusion</h3> This study casts doubt on the value of faecal calprotectin in the routine evaluation of patients presenting with lower GI symptoms. Invasive investigations prompted by elevated results proved normal much more often than abnormal. The assay seems most helpful in evaluating patients with symptoms suggestive of IBS with abnormal blood tests, and in those in whom previous investigations were equivocal for IBD <h3>Disclosure of Interest</h3> None Declared.
Echocardiographic Findings in Discrete Subvalvular Aortic Stenosis
Authors: RICHARD L. POPP, JAMES F. SILVERMAN, JAMES W. FRENCH, EDWARD B. STINSON, DONALD C. HARRISON
Journal: Circulation (1974)

Echographic features of three patients with discrete subvalvular aortic stenosis are presented. These include a narrowed area of the left ventricular outflow tract just below the aortic valve cusps in all cases. A high-intensity but thin echo was seen in the high left ventricular outflow tract at the level of the mitral annulus in one patient with a subaortic diaphragm. In one of the three patients abnormality of aortic cusp motion was suggested as well.
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
Authors: Philipp A Lang, Marcus Schenck, Jan P Nicolay, Jan Ulrich Becker, Daniela S Kempe, Adrian Lupescu, Saisudha Koka, Kerstin Eisele, Barbara A Klarl, Herbert Rübben, Kurt W Schmid, Klaus Mann, Sibylle Hildenbrand, Harald Hefter, Stephan M Huber, Thomas Wieder, Andreas Erhardt, Dieter Häussinger, Erich Gulbins, Florian Lang
Journal: Nature Medicine (2007)
Work-Up for Hypertension
Authors: Claus A. Pierach
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Talso's (<b>219</b>:1224, 1972) answer to the question of how to evaluate a patient with elevated blood pressure is somewhat misleading. The sequence of elaborate studies for detection of possible renovascular hypertension should be reversed. Split renal-function determinations and assay of renal-vein plasma renin levels are not considered screening tests. They are only indicated and meaningful if on a preceding renal arteriogram a vascular lesion was found whose significance may be elucidated by these tests. Talso advises that split renal-function studies be done and renal venous plasma renin activity be measured. I do not know of any evidence that the combination of both of these painstaking tests adds anything. Their value seems to be equal.<sup>1</sup>
Medical management of the patient with angina pectoris: an overview of the problem.
Authors: T J Reeves
Journal: Circulation (1982)

The medical management of angina pectoris requires a comprehensive approach to the patient and his family, including attention not only to established physiologic and pharmacologic principles, but also to the emotional aspects of his illness. When comprehensive management is systematically and rigorously applied to the patient with angina pectoris, excellent relief of the symptoms of angina pectoris can be achieved in a high percentage of patients, although there are significant numbers of patients who are refractory to the most intensive management using presently available drugs. The same fundamental principles of care apply to patients with coronary heart disease who undergo aortocoronary bypass surgery and to those treated medically.
Evidence of Limited Variability of Antigen Receptors on Intrathyroidal T Cells in Autoimmune Thyroid Disease
Authors: Terry F. Davies, Andreas Martin, Erlinda S. Concepcion, Peter Graves, Lydia Cohen, Avi Ben-Nun
Journal: New England Journal of Medicine (1991)

Patients with autoimmune thyroid diseases, including Graves' disease and Hashimoto's disease, have marked lymphocytic infiltration in their thyroid glands. We examined the gene for the variable regions of the α-chain of the human T-cell receptor (the Vα gene) in intrathyroidal T cells to determine whether the infiltration is a secondary heterogeneous immune response or a more restricted, and therefore primary and presumably pathogenetic, reaction to thyroid autoantigens.
Jogger's Heel
Authors: Irwin M. Siegel
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The benefits from any sport should be balanced against harmful effects secondary to the type of exercise performed. As Americans enthusiastically take to the gyms and playing fields, medical practice becomes enlarged by pathologic entities such as tennis elbow, baseball finger, and swimmer's ear. This communication presents several cases of heel pad discomfort secondary to a program of daily jogging, so-called joggers' heel. The jog is an alternating fast walk and slow run using a heel-toe gait. A graded jogging program usually aims for at least 1 mile of such activity daily. This is often performed on a nonresilient surface, such as a sidewalk or street. Ankle injury secondary to jogging has been previously noted.<sup>1</sup> <h3>Case 1.—</h3> A 32-year-old man complained of persistent bilateral heel pain ten days after beginning to jog. In spite of discomfort, he continued jogging 1 mile each morning. Pain was most
994-99 Can Late Saphenous Vein Graft Closure Be Predicted by Quantitative Angiographic Analysis Before the Clinical Event?
Authors: Carl W. White, Jozsef Vanyi, Gladwin Das, Susan Meyer, Lucien Campeau, James Forrester, J. Alan Herd, Byron Hoogwert, Donald Hunninghake, Irvin Goldenberg, Michael Domanski, Genell Knatterud
Journal: Journal of the American College of Cardiology (1995)
CINCHONA DERIVATIVES IN THE TREATMENT OF HEART DISORDERS
Authors: K. F. WENCKEBACH
Journal: JAMA (1923)

Quinin has been used in heart treatment for a long time, certainly for more than sixty years. I must confess that I have not had time in these last years to look up the history of quinin as a heart drug, but I have heard that Ludwig Traube, the most outstanding man in experimental work in connection with clinical findings, added quinin to digitalis to prevent or relieve the disagreeable action of this drug on the stomach. I do not know whether this is true or not, but it is so related. Among the older generation of clinicians there was a good number, and I knew some of them, who nearly always gave digitalis in combination with quinin. On being asked why they did it, they could not give me an exact reason for it; but they found that digitalis was better supported with quinin and that they could give