Systemic Complications of Local Podophyllin Therapy
Authors: GARY P. STOEHR
Journal: Annals of Internal Medicine (1978)

Brief Reports1 September 1978Systemic Complications of Local Podophyllin TherapyGARY P. STOEHR, Pharm.D., ANN L. PETERSON, M.D., WILLIAM J. TAYLOR, Pharm.D.GARY P. STOEHR, Pharm.D., ANN L. PETERSON, M.D., WILLIAM J. TAYLOR, Pharm.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-3-362 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough thrombocytopenia and leukopenia have occurred after treatment with the investigational antineoplastic agent epipodophyllotoxin (VM-26) (1), bone marrow toxicity has not been observed after treatment with the parent compound podophyllin. We have recently observed a case of leukopenia and thrombocytopenia resulting from local podophyllin (podophyllum resin) treatment of condyloma acuminata.A 15-year-old black girl was admitted to Duke Hospital on 14 September 1977 for surgical excision of congenital cutaneous nevi of the left arm and leg. With the exception of a linear cutaneous nevus and the presence of a large fungating growth involving the inner aspect of the upper left...References1. MUGGIASELAWRYHANSEN FOH: Clinical studies with a new podophyllotoxin derivative, Epipodophyllotoxin, 4′-demethyl-9-(4, 6-O-2-thenylidine-β-D-glucopyranoside) (NSC-122819). Cancer Chemother Rep 55:575-581, 1971 MedlineGoogle Scholar2. WARDCLIFFORDMONACOBICKERSTAFF JWAH: Fatal systemic poisoning following podophyllin treatment of condyloma acuminatum. South Med J 47:1204-1206, 1954 CrossrefMedlineGoogle Scholar3. MONTALDIGIAMBRONECOUREYTAEFI DJNP: Podophyllin poisoning associated with the treatment of condyloma acuminatum: a case report. Am J Obstet Gynecol 119:1130-1131, 1974 CrossrefMedlineGoogle Scholar4. BALUCANIZELLERS MD: Podophyllum resin poisoning with complete recovery. JAMA 189:639-640, 1964 CrossrefMedlineGoogle Scholar5. WILSONBRYAN LJ: Biochemical and pharmacological properties of microtubles, in Advances in Cellular and Molecular Biology, Vol. 1, edited by DU PRAW EJ. New York, Academic Press, 1974, pp. 21-72 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. 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RATE, M.D., JACQUES LECHE, R.PH., CAROL CHERVENAK, R.PH.Podophyllin TherapyHARRY L. ARNOLD JR., M.D. 1 September 1978Volume 89, Issue 3Page: 362-363KeywordsBone marrowToxicity Issue Published: 1 September 1978 PDF DownloadLoading ...