tbuckley/cabot-search huggingface dataset:
Inappropriate Secretion of Antidiuretic Hormone from Fluphenazine Therapy
Authors: J. L. G. DE RIVERA
Journal: Annals of Internal Medicine (1975)

Letters1 June 1975Inappropriate Secretion of Antidiuretic Hormone from Fluphenazine TherapyJ. L. G. DE RIVERA, M.D.J. L. G. DE RIVERA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-811 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of inappropriate secretion of antidiuretic hormone (ADH) may be produced by several drugs (1). Phenothiazines have not been implicated so far in the production of this syndrome, although there is a recent report of inappropriate secretion of ADH associated with the structurally related tricyclic antidepressant amitriptyline (2). I wish now to report a case of inappropriate secretion of ADH most likely associated with fluphenazine therapy.The patient was admitted to the Montreal General Hospital in coma, following a convulsive episode. This 33-year-old man had been diagnosed as schizophrenic 7 years ago, and prescribed daily doses of chlorpromazine, which...References1. BARTTER F: The Syndrome of Inappropriate Secretion of Antidiuretic Hormone. Chicago, Year Book Medical Publishers, Inc., 1973 CrossrefGoogle Scholar2. LUZECKY M: The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline administration. South Med J 67:495-497, 1974 CrossrefMedlineGoogle Scholar3. RASKIND M: Psychosis, polydipsia and water intoxication. Arch Gen Psychiatry 30:112-114, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. L. G. DE RIVERA, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFluphenazine and Inappropriate Secretion of Antidiuretic HormoneJORGE S. ZUNIGA, M.D., TOBY HAZAN, M.D. 1 June 1975Volume 82, Issue 6Page: 811-812KeywordsChlorpromazineComaIntoxication ePublished: 12 March 2020 Issue Published: 1 June 1975 PDF downloadLoading ...
Selective Induction of Eotaxin Release by Interleukin-13 or Interleukin-4 in Human Airway Smooth Muscle Cells Is Synergistic with Interleukin-1 β and Is Mediated by the Interleukin-4 Receptor α -Chain
Authors: Stuart J. Hirst, Matthew P. Hallsworth, Qi Peng, Tak H. Lee
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

The biologic activities of interleukin (IL)-13 and IL-4 often overlap, and evidence supports their importance in atopic disease and airways hyperresponsiveness. Here, their capacity to release eosinophil-activating cytokines was examined in cultured human airway smooth muscle. IL-13 and IL-4 induced selective release of eotaxin with no effect on granulocyte-macrophage colony-stimulating factor, regulated upon activation, normal T-cell expressed and secreted (RANTES), or IL-8. A profound synergistic increase in eotaxin release occurred when IL-13 or IL-4 was combined with IL-1 β that was abrogated by a neutralizing antibody to the IL-4 receptor α (IL-4R α )-chain but not to the IL-2 receptor γ (IL-2R γ )-chain. Expression of cell surface IL-4 receptors and IL-4R α in lysates was constitutive and unchanged by treatment with IL-13 or IL-4 alone or in combination with IL-1 β . Activation of IL-4R α by IL-13 or IL-4 induced signal transducer and activation of transcription-6 (STAT6), p42/ p44 ERK, p38, and to a lesser extent, SAPK/JNK mitogen-activated protein kinase phosphorylation. STAT6 and MAP kinase activation by IL-13 or IL-4 was not further potentiated after combined stimulation with IL-1 β . However, eotaxin release induced by IL-13 or IL-4 alone, and in combination with IL-1 β , was prevented by the MEK inhibitor U 0126 and by the p38 inhibitor SB 202190. Collectively, the data suggest that selective eotaxin release induced either by IL-13 and IL-4 or when combined with IL-1 β is mediated by a constitutive cell surface IL-4R α and the activation of multiple intracellular pathways.
Abstract A75: Circulating tumor cells in human breast cancer exhibit dynamic changes in epithelial and mesenchymal composition
Authors: Min Yu, Aditya Bardia, Ben Wittner, Shannon Stott, Malgorzata Smas, David Ting, Steven Isakoff, Jordan Ciciliano, Marissa Wells, Ajay Shah, Kyle Concannon, Maria Donaldson, Lecia Sequist, Elena Brachtel, Dennis Sgroi, Jose Baselga, Sridhar Ramaswamy, Mehmet Toner, Daniel Haber, Shyamala Maheswaran
Journal: Cancer Research (2013)

Abstract Epithelial mesenchymal transition (EMT) has been postulated to contribute to the dissemination of cancer cells, but supporting histopathological evidence is limited. We used a microfluidic device to isolate circulating tumor cells (CTCs), combined with multiplex RNA-in-situ hybridization (ISH) and RNA sequencing, to quantify and characterize EMT in breast CTCs. Whereas only rare cells in the primary tumor expressed both mesenchymal and epithelial markers, such biphenotypic as well as purely mesenchymal cells were enriched among CTCs, across all histological subtypes of breast cancer. Analysis of treatment responses in 10 patients suggested an association of mesenchymal CTCs with disease progression. In an index patient followed longitudinally, fluctuation in epithelial and mesenchymal states was observed as a function of initial response and subsequent resistance to therapy. Mesenchymal markers were predominant in clusters of tumor cells, many of which had adherent platelets. Finally, RNA sequencing of CTC clusters identified EMT-related signatures, including FOXC1, a known transcriptional regulator of EMT. Together, these data support a role for EMT in the blood-borne dissemination of breast cancer and point to the dynamic nature of this cell fate change. Citation Format: Min Yu, Aditya Bardia, Ben Wittner, Shannon Stott, Malgorzata Smas, David Ting, Steven Isakoff, Jordan Ciciliano, Marissa Wells, Ajay Shah, Kyle Concannon, Maria Donaldson, Lecia Sequist, Elena Brachtel, Dennis Sgroi, Jose Baselga, Sridhar Ramaswamy, Mehmet Toner, Daniel Haber, Shyamala Maheswaran. Circulating tumor cells in human breast cancer exhibit dynamic changes in epithelial and mesenchymal composition. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A75.
An Evaluation of the Carcinoembryonic Antigen (CEA) Test for Monitoring Patients With Resected Colon Cancer
Authors: Charles G. Moertel
Journal: JAMA (1993)

To determine the effectiveness of carcinoembryonic antigen (CEA) monitoring in detecting surgically curable recurrence of colon cancer.Clinical data were collected from a national surgical adjuvant trial in which CEA monitoring was elective.Cancer centers, universities, and community clinics.A total of 1216 patients with resected colon cancer, 1017 (84%) of whom had CEA monitoring.Sensitivity and specificity of CEA testing for cancer recurrence and CEA-motivated diagnostic and surgical interventions and their end results.Among 417 monitored patients with recurrence, 59% had a preceding elevation of CEA concentration. Sixteen percent of 600 patients without recurrence showed a false-positive test result. Carcinoembryonic antigen testing was most sensitive for hepatic or retroperitoneal metastasis and relatively insensitive for local, pulmonary, or peritoneal involvement. Surgical explorations were performed in 115 patients with CEA elevations, and 47 recurrences, usually hepatic, were resected with curative intent. On the other hand, 38 patients with normal CEA concentrations and 23 patients not monitored also underwent such resections--usually for pulmonary or local recurrence. Of all CEA-monitored patients, 2.3% are alive and disease free more than 1 year after salvage surgery (2.9% of those with CEA elevations and 1.9% of those with no elevations). Of patients with no CEA monitoring, 2.0% are also alive and disease free more than 1 year after salvage surgery.Cancer cures attributable to CEA monitoring are, at best, infrequent. It is questionable whether this small gain justifies the substantial cost in dollars and physical and emotional stress that this intervention may cause for patients.
1216 IN VITRO INHIBITION OF HEPATIC BILIRUBIN TRANSPORTERS BY THE HCV NS3 PROTEASE INHIBITOR GS-9451 AND IN VIVO CORRELATION IN HEALTHY SUBJECTS
Authors: J.C. Yang, C. Yang, A. Mathias, L. Moorehead, D. Brainard, L. Tong, J. Mwangi, A. Roy, B. Murray, I. Lepist, A.S. Ray, W. Delaney, J.G. McHutchison
Journal: Journal of Hepatology (2012)
Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis
Authors: Halina Offner, Kirsten Adlard, Alex Zamora, Arthur A. Vandenbark
Journal: Journal of Clinical Investigation (2000)

Transgenic mice expressing the BV8S2 chain, which is specific for the myelin basic protein determinant Ac1-11, possess a naturally induced set of regulatory T cells directed against BV8S2. Further activation of anti-BV8S2 T cells in male mice with recombinant BV8S2 protein can inhibit IFN-γ release by Ac1-11–specific T cells through a cytokine-driven mechanism and prevent induction of experimental autoimmune encephalomyelitis (EAE). In contrast, naive female mice possess fewer anti-BV8S2–reactive T cells, and treatment with BV8S2 delayed but did not prevent EAE. We here demonstrate that combining T-cell receptor (TCR) vaccination with supplemental estrus doses of estrogen potentiated IL-10 production by anti-BV8S2–reactive T cells and induced Ac1-11–specific T cells to produce IL-10 and TGF-β. This combined treatment resulted in full protection against EAE, which was not observed with either therapy alone. These findings imply that supplemental estrogen can enhance the efficacy of TCR-based immunotherapy for autoimmune diseases that predominate in females.
DILATATION OF THE HEART
Authors: D. W. Samways
Journal: BMJ (1921)

MDCJibegun at once and continued four-hourly.The urine cleared Ln thirty-six hours and the temperature dropped.Besides the cases noted in this paper we have treated with vitex in Ranchi some 60 cases of malarial fever, and we have under treatment a -case of blackwater fever which occurred at Rengari in a European nun.This patient had recovered from the original attack of black- water fever under treatment with Aphloeia theaeforntis, and was brought into Ranchi with her urine still very dark and with abundance of bile in it, and obviously on the edge of a relapse.She was a very severe case to start with, and was in a very critical condition on arrival here.Under infusion of vitex (2in40) her urine absolutely cleared in thirty-six hours, her fever
US Biomedical Research
Authors: Elias A. Zerhouni
Journal: JAMA (2005)

The National Institutes of Health (NIH) is the world's largest biomedical research agency, with a 75-year record of responding to the nation's key medical challenges. Today, medical science is entering a revolutionary period marked by a shift in focus from acute to chronic diseases, rapidly escalating health care costs, a torrent of biological data generated by the sequencing of the human genome, and the development of advanced high-throughput technologies that allow for the study of vast molecular networks in health and disease. This unique period offers the unprecedented opportunity to identify individuals at risk of disease based on precise molecular knowledge, and the chance to intervene to preempt disease before it strikes. Conceptually, this represents the core scientific challenge of the coming century. The NIH is committed to the discoveries that will change the practice of medicine as we know it in order to meet this challenge. The NIH Roadmap constitutes an important vehicle for generating change-a most critical element of this plan is the reengineering of the national clinical research enterprise. This reinvention will call for the transformation of translational clinical science and for novel interdisciplinary approaches that will advance science and enhance the health of the nation.
1028. Reduction of Replication of Oncolytic Adenoviruses with Pharmacological Intervention: Treatment of Replication Associated Toxicity
Authors: Anna Kanerva, Mari Raki, Lotta Kangasniemi, Renee A. Desmond, Helena Isoniemi, Krister Hockerstedt, Akseli Hemminki
Journal: Molecular Therapy (2005)

Effective tumor transduction continues to be the limiting step for achieving clinical results with gene therapy agents. The use of oncolytic viruses such as conditionally replicating adenoviruses (CRAds) might prove useful in this regard. These viruses have a cytolytic nature, i.e. the replicative life cycle of the virus results in host cell destruction. Normal tissue is spared due to restriction of replication. The first clinical cancer trial with replicating adenoviruses was published in 1956 with various wild-type strains. More recently, increasing understanding of adenovirus replication and its interactions with cellular proteins and the immune system have allowed us to create more effective recombinant adenoviruses for cancer gene therapy. However, with more effective therapy regimens an increase in side effects is also possible. We hypothesized that we may be able to increase the safety of CRAds by developing means for pharmacological intervention for reduction of replication, which might be useful in the event of severe side effects in trials. Some tumor/tissue specific promoters might be amenable to pharmacological abrogation of CRAd replication. Further, some general steps in the viral replication cycle could be utilized for reduction of replication. We analyzed the effect of anti-inflammatory substances on cyclooxygenase-2 and vascular endothelial growth factor promoter based CRAds. Further, the inhibition of clathrin-dependent endocytosis by cationic amphiphilic drugs (CAD) was evaluated. CADs inhibit the assembly of the clathrin adapter protein AP2 on clathrin-coated pits, and cause the pits to disappear from the cell surface and reappear on endosomal membranes. Finally, a natural bioflavonoid compound was evaluated for its efficacy on tumor growth inhibition, regulation of the cell cycle and apoptosis, and therefore, effect on viral replication. We analyzed the in vitro cell killing efficacy of selected CRAds in the presence and absence of the substances. Further, in vitro replication in cell lines and human liver explants was measured. Moreover, the effect on in vivo efficacy and replication of the CRAds was evaluated. Detailed results will be presented in the meeting. On the basis of our results, we propose that the analyzed substances might reduce the replication of CRAds and of wild-type adenovirus and this could thereby provide a putative safety switch in case of side effects. Importantly, many of the identified substances are already clinically approved and therefore immediately usable in ongoing and forthcoming trials.
1113-164 Assessment of the proximal aorta by real-time three-dimensional echocardiography
Authors: Marie-Edouard N Desvarieux, Kumiko Hirata, Todd Pulewitz, Eugene Shteerman, Steve Nadelberg, F.Khady Fall, Samira Rivera, Shunichi Homma, Marco R Di Tullio
Journal: Journal of the American College of Cardiology (2004)
A PROFILE OF HOSPITAL FUNCTIONING
Authors: RALPH M. CHAMBERS, MESROP A. TARUMIANZ, KENNETH E. APPEL
Journal: American Journal of Psychiatry (1951)

A graphic method of presenting the functional efficiency or evaluation of a mental hospital has been developed in the form of a Profile. A few tables of statistics have been developed to point up the picture of facilities, personnel, and operation of a hospital. Such abbreviated, condensed, pictorial summaries are needed when one tries to comprehend such a complex phenomenon as a public mental hospital in a unitary view. The Profile is not presented as anything definitive but as a tentative method of presenting a diversity of elements in brief compass. It not only helps the evaluation of a given hospital, but will enable any board or group to compare hospitals and thus make rating fairer and more comparable. Such a Profile should help a staff, superintendent, and Board of Trustees to carry a clear picture of the functional adequacy of their hospital in mind and turn their thinking to rectifying the not acceptable or absent elements in the Profile. The Profile should, because of its abbreviated, condensed, and graphic nature, afford an effective tool for public education with regard to the mental hospitals in the United States and Canada.
Lessons in tackling chronic disease
Authors: Sania Nishtar
Journal: BMJ (2006)

Pioneering examples of partnerships in other regions are a useful source 

C hronic diseases account for about 47% of the total burden of disease in the 22 countries of the Eastern Mediterranean Region. By 2020 this figure is expected to be 60%.1 Cardiovascular disease, diabetes, cancer, and chronic lung disease account for two thirds of deaths in countries with relatively low overall mortality rates, such as Iran and Jordan, and more than 40% of deaths in those with the highest rates, such as Somalia and Sudan.2

These chronic conditions are linked by common risk factors. Some are lifestyle related—for example, low fruit and vegetable intake, lack of physical activity, and smoking—others are related to biological factors such as obesity, dyslipidaemia, and hypertension. Close to two thirds of the adult population in the region have risk factors for chronic disease; in the oil rich …
Covert video surveillance in Munchausen's syndrome by proxy
Authors: D Evans
Journal: BMJ (1994)

nephrectomy versus C660 (three days) for laparo- scopic nephrectomy.More specific, itemised analysis shows a different picture.Open nephrectomy cost C1665.64while laparoscopic nephrectomy cost £3446.58.This is due to the increased use of theatre time reported for the laparoscopic technique-355 minutes compared with 107 minutes for the open technique.In addition, the capital costs of the laparoscopic equipment and disposable items (which can be up to £450 for a laparoscopic operation for hernia4) need to be considered.Theatre time is a costly and limited resource whose availability often determines surgical throughput and the length of a waiting list.Patients' satisfaction and recovery remain sub- jective and difficult to assess.Unless unequivocal clinical benefit can be shown, on the basis of hospital costs and throughput, many laparoscopic procedures seem hard to justify in today's NHS.
Revolution in Fiction
Authors: Carleton B. Chapman
Journal: New England Journal of Medicine (1952)

A phenomenon that none foresaw and few seem to be able to understand confronts the literary critics. A young, Brooklyn-born veteran of World War II with little previous experience as a writer and no regard for tradition has almost swept the crime-novel field clean. He is Mickey Spillane, author of half a dozen yarns centering on the doings of Mike Hammer, a private eye.Spillane, and his predecessors, Dashiell Hammett and Raymond Chandler, are unfavorably scrutinized in a recent article entitled "The Decline and Fall of the Whodunit" by Ben Roy Redman.† Hammett and Chandler are said to have begun . . .
The Nature of Chronic Fatigue
Authors: David H. P. Streeten
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increased Insulin Action and Clearance in Hyperthyroid Newly Diagnosed IDDM Patient: Restoration to Normal With Antithyroid Treatment
Authors: Hubert G T Nijs, Jasper K Radder, Marijke Frölich, H Michiel J Krans
Journal: Diabetes Care (1989)

In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of 0.5, 1.0, 2.0, and 5.0 mil · kg−1 · min−1 in four steps of 2 h. The data were compared with nine control subjects and nine newly diagnosed euthyroid IDDM patients treated with insulin for 0.5 mo. Insulin sensitivity was increased in the patients (ED50 40 vs. 52 mU/L, range 43–70, in controls and 70 mU/L, range 59–120, in IDDM subjects). Insulin responsiveness was markedly elevated; the steady-state glucose infusion rate (SSGIR) of step 4 was 104 vs. 64 μmol · kg−1 · min−1 (range 50–79) in controls and 61 junol · kg−1 · min−1 (range 47–69) in IDDM subjects. Insulin clearance was elevated in all steps (1-3, 20–23 vs. 9–15 ml · kg−1 · min−1; 4, 18 vs. 6–12 ml · kg−1 · min−1 in control and IDDM subjects). Parallel to the normalization of thyroid metabolism, insulin action (ED50 60 mU/L, SSGIR in step 4, 51 μmol · kg−1 · min−1) and insulin clearance (steps 1–3, 11–14 ml · kg−1 · min−1; step 4, 7 ml · kg−1 · min−1) returned to the normal range in 6 mo. Both remained within the normal range until 12 mo. In the patient with newly diagnosed IDDM, the initial marked increases of insulin action and clearance were due to coexistent hyperthyroidism. With the amelioration of the hyperthyroid state, both processes became normal. The parallelism between insulin action and clearance suggests a functional relationship.
PROSPECT AND RETROSPECT
Authors: HENERY MACCORMAC
Journal: British Journal of Dermatology (1946)

Journal Article PROSPECT AND RETROSPECT Get access HENERY MACCORMAC, C. B. E., M. D., F. R. C. P HENERY MACCORMAC, C. B. E., M. D., F. R. C. P Being the Lumleian Lecture (adridged): delivered before the Royal College of Physicians 17 April 1945 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 58, Issue 5-6, 1 May 1946, Pages 97–111, https://doi.org/10.1111/j.1365-2133.1946.tb16283.x Published: 01 May 1946
FAMILIAL DEFECT OF CD3 (T3) EXPRESSION BY T CELLS ASSOCIATED WITH RARE GUT EPITHELIAL CELL AUTOANTIBODIES
Authors: J.R. Regueiro, A. Arnaiz-Villena, M. ORTIZ DE LANDÁZURI, J.M.Martín Villa, J.L. Vicario, V. Pascual-Ruiz, F. Guerra-Garcia, J. Alcamí, M. López-Botet, J. Manzanares
Journal: The Lancet (1986)