tbuckley/cabot-search huggingface dataset:
Capillary Distribution in the Ventricles of Hearts With Pulmonary Atresia and Intact Ventricular Septum
Authors: Petra W. Oosthoek, Antoon F.M. Moorman, Ursula Sauer, Adriana C. Gittenberger-de Groot
Journal: Circulation (1995)

Background Pulmonary atresia and intact ventricular septum (PA-IVS) can be complicated by the presence of a severely hypoplastic thick-walled right ventricle with or without ventriculo–coronary arterial communications. A variable amount of myocardial pathology has been described in these hearts, probably the result of ischemic conditions and a high pressure in the right ventricle. We studied whether the capillary network is still intact, allowing a sufficient perfusion of the myocardium, which will be important for the success of palliative surgery. Methods and Results We studied the distribution of capillaries in the myocardium of hearts with PA-IVS and compared the results with normal hearts. The capillaries were detected by immunohistochemistry using a monoclonal antibody (408) against endothelium. Remarkable abnormalities in capillary distribution were found in the right ventricle of hearts with PA-IVS and reflect the arrangement of the myocytes. Thus, disorganization of capillaries, which is found to be the most common pattern, always paralleled the myocardial disarray. A low density of capillaries is always found in areas with a low density of myocytes, ie, with hypertrophied myocytes, compact fibrotic tissue, or diffuse fibrosis. Disarray and other disturbances in orientation of capillaries and myocytes are present in hearts with PA-IVS, a hypoplastic right ventricle, and ventriculo–coronary arterial communications. These disturbances are more extensive when interruptions of the coronary arteries are also present. In hearts with PA-IVS and a hypoplastic right ventricle only, extensive regions with low capillary densities and severe myocyte pathology are observed. On the contrary, hearts with PA-IVS and a normal-size right ventricle show minor abnormalities in capillary and myocyte organization. Conclusions In hearts with PA-IVS, various abnormal capillary distribution patterns are found. Our findings correlate well with clinical data that reported the best surgical results in hearts in which the major part of the myocardium showed a normal capillary distribution and myocyte morphology. This suggests that the capillary distribution may be an important parameter for the function of the heart. Because the distribution of the capillaries is found to be a good reflection of the arrangement of the myocytes, antibody 408 is also a useful tool in detecting abnormalities of the myocardium in a fast and easy way.
Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.
Authors: P D Greenberg, M A Cheever, A Fefer
Journal: The Journal of Experimental Medicine (1981)

The phenotype of T cells therapeutically effective in immunotherapy of advanced Friend virus-induced (FBL) leukemia in vivo and cytotoxic to FBL in vitro was determined. Mice bearing disseminated FBL leukemia were successfully treated by a combination of cyclophosphamide and adoptive transfer of syngeneic immune lymphocytes. Therapeutic efficacy was largely dependent on the presence of Lyt-1+2- T cells in the transferred cells, whereas cells cytotoxic to FBL tumor in vitro were derived from the Lyt-1+2+ and Lyt-1-2+ subsets. Thus, the predominate cell required to eradicate tumor in adoptive chemoimmunotherapy was not cytolytic to tumor in vitro. Potentially, the Lyt-1+2- cell may operate in vivo as an amplifier cell rather than by a direct anti-tumor effect. Elimination of the Lyt-1+ population with alpha-Lyt-1 and complement prevented the generation of significant cytotoxic responses during both primary in vitro sensitization to alloantigens and in vitro sensitization of tumour-primed cells. The capacity of Lyt-1+ cell-depleted population to generate cytotoxic responses was partially reconstituted by addition, at the initiation of culture, of interluekin 2, a T cell growth factor derived from Lyt-1+2- cells, which contain the CTL and CTL precursors, were nearly as effective in vitro as unseparated immune cells. If the remaining effector cells (i.e., Lyt-1+2- T cells) function in vivo predominantly as amplifier cells, than the tumour-bearing host must be capable of making a positive contribution to the outcome of therapy.
Cardiopulmonary Resuscitation Quality: Improving Cardiac Resuscitation Outcomes Both Inside and Outside the Hospital
Authors: Peter A. Meaney, Bentley J. Bobrow, Mary E. Mancini, Jim Christenson, Allan R. de Caen, Farhan Bhanji, Benjamin S. Abella, Monica E. Kleinman, Dana P. Edelson, Robert A. Berg, Tom P. Aufderheide, Venu Menon, Marion Leary
Journal: Circulation (2013)

The "2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care" increased the focus on methods to ensure that high-quality cardiopulmonary resuscitation (CPR) is performed in all resuscitation attempts. There are 5 critical components of high-quality CPR: minimize interruptions in chest compressions, provide compressions of adequate rate and depth, avoid leaning between compressions, and avoid excessive ventilation. Although it is clear that high-quality CPR is the primary component in influencing survival from cardiac arrest, there is considerable variation in monitoring, implementation, and quality improvement. As such, CPR quality varies widely between systems and locations. Victims often do not receive high-quality CPR because of provider ambiguity in prioritization of resuscitative efforts during an arrest. This ambiguity also impedes the development of optimal systems of care to increase survival from cardiac arrest. This consensus statement addresses the following key areas of CPR quality for the trained rescuer: metrics of CPR performance; monitoring, feedback, and integration of the patient’s response to CPR; team-level logistics to ensure performance of high-quality CPR; and continuous quality improvement on provider, team, and systems levels. Clear definitions of metrics and methods to consistently deliver and improve the quality of CPR will narrow the gap between resuscitation science and the victims, both in and out of the hospital, and lay the foundation for further improvements in the future.
P405Effects of electromagnetic radiation on the microwave range excretion 8-oxoG in men with hypertension
Authors: MN Seliuk, VS Potaskalova, AP Burlaka, NV Khaitovych, MM Kozachok, OV Seliuk
Journal: Cardiovascular Research (2014)

Oxidative DNA damage plays a significant role in pathogenesis of the majority of pathological processes, which occurs in case of excessive formation of ROS due to intense prooxidant effects or reducing the antioxidant defense system. The study has shown that oxidative stress causes endothelial dysfunction, which leads to high blood pressure stabilization in patients with AH. The study included 42 men (mean age 37,1±6,0 years) with AH, who worked from 4 to 22 years (mean age 14,6±6,8 years) under the influence of UHF EMR (group 1). The dose of UHF EMR was within the range of 4320-31065 kW (16288,7±7844,9 kW average). The control group consisted of male patients of respective age with AH, who were not exposed to prolonged UHF EMR (group 2, n=35). Body mass index in patients of group 1 was 28,5±4,7 kg/m2, patients of group 2 -29,8±3,9 kg/m2. 5 days after admission, all patients underwent daily blood pressure monitoring using the ABMP-04 "Meditech" monitors (Hungary) and were daily measured for urine marker of oxidative DNA damage 8-oxoguanine (8-oxoG) by spectrophotometry using the SF-46 unit. Daily average systolic blood pressure in 1 group of patients was 144,3±12,8 mmHg vs. 126,3±11,8 mmHg in patients of the control group (P<0,05), diastolic blood pressure 83,2±5,9 mmHg vs. 79,4±10,5 mmHg (P<0,05) respectively. The average rate of 8-oxoG excretion in group 1 patients significantly exceeded the value of those in group 2 (16,3±4,9 nmol/kg/day vs. 11,7±3,1 nmol/kg/day, P<0,05). A significant (P<0,005) direct correlation discovered between the blood pressure level and excretion rate of oxidative DNA damage marker (r=0,52), the negative relationship between the daily excretion rate of 8-oxoG and work experience (r=-0,63; P<0,001). In patients who protractedly worked in conditions of UHF EMR , the rate of DNA damage increased, which, possibly due to the genome operation instability in endothelial cells, determined the high daily average level and low blood pressure control. The results can be used as a marker of oxidative stress during the damaging influence of UHF EMR on human's body.
Biguanides and NIDDM
Authors: Clifford J Bailey
Journal: Diabetes Care (1992)

The main biguanides, metformin and phenformin, were introduced in 1957 as oral glucose-lowering agents to treat non-insulin-dependent diabetes mellitus (NIDDM). Phenformin was withdrawn in many countries because of an association with lactic acidosis, but metformin does not have the same risk if appropriately prescribed. Metformin is now widely used as a monotherapy and in combination with a sulfonylurea. Unlike sulfonylureas, metformin is not bound to plasma proteins, is not metabolized, and is eliminated rapidly by the kidney. The glucose-lowering effect occurs without stimulation of insulin secretion and results mainly from increased glucose utilization. The presence of insulin is required, and enhancement of insulin action at the postreceptor level occurs in peripheral tissues such as muscle. In peripheral tissues metformin increases insulin-mediated glucose uptake and oxidative metabolism. Metformin also increases glucose utilization by the intestine, primarily via nonoxidative metabolism. The extra lactate produced is largely extracted by the liver and serves as a substrate to sustain gluconeogenesis. This limits the extent to which metformin reduces hepatic glucose production but provides a safeguard against excessive glucose lowering. Because metformin does not cause clinical hypoglycemia, it is actually an antihyperglycemic drug. It does not cause weight gain, it helps combat hypertriglyceridemia, and it has been ascribed some vasoprotective properties. Metformin offers a useful treatment for insulin-resistant overweight NIDDM patients.
Parathyroidectomy rates among United States dialysis patients: 1990–199911See Editorial by Goodman, p. 335.
Authors: Bryan Kestenbaum, Stephen L. Seliger, Daniel L. Gillen, Haimanot Wasse, Bessie Young, Donald J. Sherrard, Noel S. Weiss, Catherine O. Stehman-Breen
Journal: Kidney International (2003)
Certolizumab Pegol for Active Crohn's Disease: A Placebo-Controlled, Randomized Trial
Authors: William J. Sandborn, Stefan Schreiber, Brian G. Feagan, Paul Rutgeerts, Ziad H. Younes, Ralph Bloomfield, Geoffroy Coteur, Juan Pablo Guzman, Geert R. D'Haens
Journal: Clinical Gastroenterology and Hepatology (2011)
Outbreak of Mycobacterium chelonae Infection Associated With Use of Jet Injectors
Authors: Jay D. Wenger
Journal: JAMA (1990)

Between January 1 and May 15, 1988, foot infections due to Mycobacterium chelonae subspecies abscessus were diagnosed in eight persons who had undergone invasive procedures at a podiatry office. A cohort study was performed to evaluate risk factors for disease. Persons who underwent procedures before 10:30 AM were more likely to have developed infection than those with procedures after that time (relative risk, 5.6). In addition, procedures involving any of the second through fourth toes were more likely to have resulted in infection than procedures involving only the first and/or fifth toes (relative risk, 4.4). Persons with 0, 1, or 2 risk factors had attack rates of 5%, 14%, and 60%, respectively. Mycobacterium chelonae subspecies abscessus organisms of the same antimicrobial resistance pattern as the patients' strains were cultured from distilled water in a reusable, nonsterilized container. A jet injector used to administer lidocaine was held between procedures in a mixture of the distilled water and a disinfectant as recommended by the manufacturer. Inoculation of patients with mycobacteria by the jet injector may have only occurred early in the day due to slow killing of the bacteria by the disinfectant. The outbreak emphasizes the pathogenicity of this water-associated organism and the need for high-level disinfection of jet injectors.
DESCRIPTION OF A CASE OF ORAL SURGERY.
Authors: G. V. I. BROWN
Journal: JAMA (1900)

The deformity shown in Figure 1 was caused by a burn at the age of 3 years, the patient being, at the time of operation, about 20 years old. The chin was held tightly against the breast by the cicatricial tissue; one arm and hand were also grown to the breast, the wrist being turned so that the thumb was twisted back upon itself, its palmar surface next the skin of the patient's chest. By reason of the continual strain occasioned by the effort of the muscles of the back of the neck constantly endeavoring to hold the head up, in order to enable the subject to look straight before him, the lower jaw was deformed and elongated in such a manner that the first inferior molars met the superior cuspids in occlusion, the anterior lower teeth protruding forward in the shape of a fan, giving an expression to the
Optimum therapeutic hypothermia temperature after perinatal asphyxia: a magnetic resonance spectroscopy biomarker and immunohistochemistry study in the newborn piglet
Authors: Jane K Hassell, Mani Chandrasekaran, Stuart D Faulkner, Alan Bainbridge, Bobbi Fleiss, Kate Bennett, Ern Cady, Gennadij Raivich, Pierre Gressens, Xavier Golay, Nicola J Robertson
Journal: The Lancet (2014)
INHIBITION OF TUBERCULIN SKIN HYPERSENSITIVITY IN GUINEA PIGS BY INJECTION OF TUBERCULIN AND INTACT TUBERCLE BACILLI DURING FETAL LIFE
Authors: David W. Weiss
Journal: The Journal of Experimental Medicine (1958)

FEMALE GUINEA PIGS WERE SUBJECTED TO LAPAROTOMY AT DIFFERENT STAGES OF PREGNANCY, AND THEIR FETUSES INJECTED THROUGH THE UTERINE WALLS WITH ONE OF THE FOLLOWING PREPARATIONS: Old Tuberculin, tubercle bacilli of the BCG strain killed by heat or exposure to phenol, and living BCG. A large number of the animals injected in utero with Old Tuberculin failed to develop skin hypersensitivity to P.P.D. following vaccination with 200 or 800 gamma phenol-killed tubercle bacilli (BCG) in early adulthood. Normal control animals were sensitized by vaccination with such quantities of phenolized BCG. The failure of animals which had been injected with Old Tuberculin in fetal life to respond hypersensitively to P.P.D. after adult vaccination with tubercle bacilli is ascribed to their acquisition of a state of immunological tolerance to tuberculoprotein (tuberculin tolerance). Fetal injection with killed BCG conferred a state of tolerance on a few of the animals, and rendered others tuberculin-sensitive. Fetal injection with living BCG sensitized most of the animals to tuberculin, even when fetal exposure was as early as 46 days before birth, and induced tolerance in none. Fetuses of the same litter, injected simultaneously with identical inocula, often responded differently, some becoming tolerant to tuberculin, others developing hypersensitivity, and still others remaining immunologically unaffected, becoming neither sensitive nor tolerant. The state of tuberculin tolerance induced in these experiments was limited. When tolerant animals were revaccinated with living BCG several weeks after vaccination with phenol-killed bacilli, they developed as high a degree of tuberculin skin sensitivity as the originally non-tolerant animals.
Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: effects on right ventricular function.
Authors: P Van der Linden, O Le Moine, M Ghysels, M Ortinez, J Devière
Journal: Hepatology (1996)

The short- and mid-term hemodynamic effects of transjugular intrahepatic portosystemic shunt (TIPS) were studied in 16 sedated cirrhotic patients. Indications included relapsing variceal bleeding (n = 10) and refractory ascites (n = 6). The decrease of porto-atrial pressure gradient (from 20.4 +/- 4.2 mm Hg to 10.1 +/- 2.4 mmHg; P < .05) was associated with an increase of mean pulmonary artery pressure (MPAP) (from 12.3 +/- 3.0 mm Hg to 20.3 +/- 5.3 mm Hg; P < .05) and of right atrial pressure (RAP) from 3.4 +/- 2.6 mm Hg to 8.3 +/- 3.7 mm Hg; P < .05), whereas right ventricular end-diastolic volume (RVEDVI) remained unchanged. The significant increase of cardiac index (CI) (from 4.5 +/- 1.2 L/min/m2 to 5.0 +/- 1.1 L/min/m2; P < .05) was essentially attributable to an increase of heart rate (HR) (from 81 +/- 11 to 88 +/- 10 beats/min; P < .05). Systemic vascular resistance (SVR) decreased (from 812 +/- 281 to 666 +/- 191 dynes/sec/cm5; P < .05), whereas pulmonary vascular resistance (PVR) increased (from 60.6 +/- 29.6 to 82.0 +/- 34.6 dynes/sec/cm5; P < .05). After transient shunt occlusion with a balloon catheter, all of the hemodynamic parameters returned to baseline values, except pulmonary artery pressure, which also decreased but remained significantly increased. One month after TIPS, pulmonary pressure remained elevated, and CI further increased. It is concluded that increased PVR is the major hemodynamic alteration occurring after TIPS placement. It correlates with the decrease of porto-atrial gradient and is probably mediated by both mechanical and neurohumoral factors.
RECURRENT CALCULI IN THE URINARY TRACT
Authors: FREDERICK T. LAU
Journal: JAMA (1925)

Believing that perhaps more light could be thrown on the interesting subject of recurrent calculi by an exhaustive study of cases in a clinic as yet unheard from on this problem, I undertook this investigation.  Surgical procedure for vesical calculi greatly antedates that for kidney and ureteral calculi. Ultzman1quotes Olympios of Athens as having shown that lithotrity was done in the ninth century. About 1560, Pierre France first removed a vesical stone by suprapubic lithotomy in a child 10 years of age, and the patient recovered. Civiale, Jan. 13, 1824, actually first crushed a vesical calculus by an instrument passed through the urethra. In 1878, litholapaxy was introduced by Henry J. Bigelow of Boston. In 1871, Simon2first performed nephrectomy for renal calculus. In 1880, Czerny first performed pyelolithotomy, and in the same year, Morris first performed nephrolithotomy.  In 1901, Israel3reported a case of bilateral
Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages
Authors: Àgatha Cabrero, Marta Cubero, Gemma Llaverías, Mireia Jové, Anna Planavila, Marta Alegret, Rosa Sánchez, Juan Carlos Laguna, Manuel Vázquez Carrera
Journal: Metabolism (2003)
Chronic Myeloid Leukemia and Lithium
Authors: ROBERT T.S. JIM
Journal: Annals of Internal Medicine (1980)

Letters1 February 1980Chronic Myeloid Leukemia and LithiumROBERT T.S. JIM, M.D.ROBERT T.S. JIM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-2-262_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Among the many side-effects of lithium is leukocytosis. Tosato and colleagues (1) have recently reported the development of chronic myeloid leukemia in a patient initially presenting with acute lymphocytic leukemia who had taken lithium for 2 years previously. In the case described below the patient developed chronic myeloid leukemia after taking lithium for 11 months.On 7 December 1977, a 56-year-old Korean woman presented with a 3-month history of anorexia and abdominal pain; hepatosplenomegaly; leukocyte count of 250 000/mm3; hemoglobin, 6.1 g/dL; a differential count of segmented forms 22%, band forms 14%, metamyelocytes 26%, myelocytes 13%, promyelocytes...Reference1. TOSATOWHANG-PENGLEVINEPOPLACK GJSD. Acute lymphoblastic leukemia followed by chronic myelocytic leukemia. Blood. 1978;52:1033-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Hawaii School of Medicine Honolulu, Hawaii PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLeukemia in Bipolar Mood Disorder: Is Lithium Contraindicated?Increased leucocyte alkaline phosphatase and transcobalamin III in chronic myeloid leukaemia associated with lithium therapyLithium enhances growth of human leukaemia cells in vitroEffect of lithium on normal and chronic granulocytic leukemia colony forming cells (CFU-GM)Lithium 1 February 1980Volume 92, Issue 2_Part_1Page: 262-262KeywordsAbdominal painChronic myeloid leukemiaHemoglobinHepatosplenomegalyLeukocytosisPrecursor cells Issue Published: 1 February 1980 PDF downloadLoading ...
Keratins (Kl6 and Kl7) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro
Authors: I.M. LEIGH, H. NAVSARIA, P.E. PURKIS, I.A. MCKAY, P.E. BOWDEN, P.N. RIDDLE
Journal: British Journal of Dermatology (1995)

Journal Article Keratins (Kl6 and Kl7) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro Get access I.M. LEIGH, I.M. LEIGH ICRF Skin Tumour Laboratory, 56 Ashfield Street, London E1 2BL, U.K. Search for other works by this author on: Oxford Academic Google Scholar H. NAVSARIA, H. NAVSARIA Department of Experimental Dermatology. London Hospital Medical College, London E1 1BB, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.E. PURKIS, P.E. PURKIS ICRF Skin Tumour Laboratory, 56 Ashfield Street, London E1 2BL, U.K. Search for other works by this author on: Oxford Academic Google Scholar I.A. MCKAY, I.A. MCKAY Department of Experimental Dermatology. London Hospital Medical College, London E1 1BB, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.E. BOWDEN, P.E. BOWDEN Department of Dermatology. University of Wales, College of Medicine, Heath Park, Cardiff CF4 4XN. U.K. Search for other works by this author on: Oxford Academic Google Scholar P.N. RIDDLE P.N. RIDDLE ICRF, Lincoln's Inn Field. London WC2. U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 4, 1 October 1995, Pages 501–511, https://doi.org/10.1111/j.1365-2133.1995.tb02696.x Published: 01 October 1995 Article history Accepted: 09 November 1994 Published: 01 October 1995