Amylase/Creatinine Clearance Fraction in Patients on Chronic Hemodialysis
Authors: CHARLES F. SCHIFFER
Journal: Annals of Internal Medicine (1977)

Letters1 January 1977Amylase/Creatinine Clearance Fraction in Patients on Chronic HemodialysisCHARLES F. SCHIFFER, M.D., JAMES F. BURKE JR., M.D., ANATOLE BESARAB, M.D., NORMAN LASKER, M.D., F.A.C.P., MICHAEL L. SIMENHOFF, M.D., M.R.C.P.CHARLES F. SCHIFFER, M.D.Search for more papers by this author, JAMES F. BURKE JR., M.D.Search for more papers by this author, ANATOLE BESARAB, M.D.Search for more papers by this author, NORMAN LASKER, M.D., F.A.C.P.Search for more papers by this author, MICHAEL L. SIMENHOFF, M.D., M.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of the amylase/creatinine clearance fraction (Cam/Ccr) in differentiating acute pancreatitis from the hyperamylasemia of renal failure was first shown in 1969 by Levitt, Rapoport, and Cooperbrand (1). The specificity of this ratio in acute pancreatitis was recently documented by Warshaw and Fuller (2). However, there have been other studies suggesting an increased Cam/Ccr in situations other than acute pancreatitis, such as diabetic ketoacidosis or extensive burns (3). Because Levitt's paper (1) used patients with mild renal failure, we elected to ascertain the extent to which the Cam/Ccr would apply in patients on chronic hemodialysis with severe renal failure....References1. LEVITTRAPOPORTCOOPERBAND MMS: The renal clearance of amylase in renal insufficiency, acute pancreatitis, and macroamylasemia. Ann Intern Med 71:919-925, 1969 LinkGoogle Scholar2. WARSHAWFULLER AA: Specificity of increased renal clearance of amylase in diagnosis of acute pancreatitis. N Engl J Med 292:325-328, 1975 CrossrefMedlineGoogle Scholar3. LEVINEGLAUSERBERK RFJ: Enhancement of the amylase-creatinine clearance ratio in disorders other than acute pancreatitis. N Engl J Med 292:329-332, 1975 CrossrefMedlineGoogle Scholar4. SCHONEBECKSODERBERG JM: Serum amylase in renal failure. Scand J Urol Nephrol 5:257-262, 1971 CrossrefMedlineGoogle Scholar5. FREDRIKSSONJACOBSON AG: Influence of renal function on the urinary excretion of amylase. Scand J Clin Lab Invest 33:313-321, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dialysis Unit Thomas Jefferson University Hospital 11th and Walnut Streets Philadelphia, PA 19107 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPancreatic enzymes in uremic patients with or without dialysisSerum Levels of Pancreatic Enzymes and their Clinical SignificanceAcute and chronic pancreatitisPancreatic Affection after Acute Hypotonic HemodialysisAcute Abdominal Pain in the Pregnant Patient Due to Pancreatitis, Acute Appendicitis, Cholecystitis, or Peptic Ulcer DiseaseThe Diagnosis of Exocrine Pancreatic Disease: The Present Position ReviewedAmylase to Creatinine Clearance Ratio in Renal DiseasesThe Value of the Amylase/Creatinine Clearance Ratio in the Diagnosis of Acute Pancreatitis 1 January 1977Volume 86, Issue 1Page: 65-66KeywordsAcute pancreatitisBurnsRenal failureSpecificity Issue Published: 1 January 1977 PDF downloadLoading ...