Linear IgA Bullous Dermatosis Associated with Vancomycin
Authors: Eric F. Bernstein
Journal: Annals of Internal Medicine (1998)

Letters15 September 1998Linear IgA Bullous Dermatosis Associated with VancomycinEric F. Bernstein, MD and Mindy Schuster, MDEric F. Bernstein, MDJefferson Medical College; Philadelphia, PA 19107University of Pennsylvania; Philadelphia, PA 19104 and Mindy Schuster, MDJefferson Medical College; Philadelphia, PA 19107University of Pennsylvania; Philadelphia, PA 19104Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-6-199809150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Linear IgA bullous dermatosis is an autoantibody-mediated subepidermal blistering disease that is rarely associated with drug exposure [1]. Clinical differentiation of this entity from more common blistering disorders such as bullous pemphigoid may not be possible on clinical grounds. It has been described in association with many medications [2-5], and vancomycin has been implicated in several patients [4, 5]. We describe two patients with severe linear IgA bullous dermatosis who received vancomycin within 2 weeks before the development of bullae.A 60-year-old woman had surgical repair of an infected enterocutaneous fistula. Ten days after beginning postoperative intravenous ...References1. Bhogal B, Wojnarowska F, Marsden RA, Das A, Black MM, McKee PH. Linear IgA disease in adults and children: a microscopic study. Br J Dermatol. 1987; 117:289-96. Google Scholar2. Gabrielsen TO, Staefelt F. Drug-induced bullous dermatosis with linear IgA deposits along the basement membrane. Acta Dermatol Venereol (Stockh). 1981; 61:439-41. Google Scholar3. Espage E, Prost C, Chosidow O, Saiag P, Revuz J, Roujeau JC. Dermatoses a IgA lineaire medicamenteuses: a propos de trois cas. Ann Dermatol Venereol. 1990; 117:898-9. Google Scholar4. Kuechle MK, Stegmeir E, Maynard B, Gibson LE, Leiferman KM, Peters MS. Drug-induced linear IgA bullous dermatosis: report of six cases and review of the literature. J Am Acad Dermatol. 1994; 30:187-92. Google Scholar5. Carpenter S, Berg D, Sidhu-Malik N, Hall RP 3d, Rico MJ. Vancomycin-associated linear IgA dermatosis. A report of three cases. J Am Acad Dermatol. 1992; 26:45-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Eric F. Bernstein, MD; Mindy Schuster, MDAffiliations: Jefferson Medical College; Philadelphia, PA 19107University of Pennsylvania; Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystemic Antibacterial AgentsVancomycin‐induced linear IgA bullous dermatosis ( LABD )—an atypical presentationOld dog begging for new tricksImmune-mediated reactions to vancomycinVancomycinVancomycin Revisited – 60 Years LaterVancomycin-Induced Linear IgA With Mucosal and Ocular InvolvementSystemic Antibacterial AgentsA critical reappraisal of the current data on drug-induced linear immunoglobulin A bullous dermatosis: A real and separate nosological entity?Bullous Dermatosis Associated With Vancomycin ExtravasationCutaneous adverse reactions to drugsVancomycin Hypersensitivity Diagnosed by Lymphocyte Blast TransformationANTIBACTERIAL DRUGSLinear immunoglobulin A bullous dermatosisAmoxicillin-clavulanic acid-induced linear immunoglobulin A bullous dermatosis: case report and review of the literatureVancomycinBullous Skin Disease: An Unusual Allergic Reaction to VancomycinLinear IgA bullous dermatosisVancomycin-induced linear IgA disease with autoantibodies to BP180 and LAD285.Positive patch test in vancomycin allergyLinear Immunoglobulin a Bullous Dermatosis Induced by GemcitabineBurn-induced linear IgA dermatosisNaproxen-Associated Linear IgA Bullous Dermatosis: Case Report and ReviewDrug-induced linear IgA bullous dermatosis after vancomycin discontinuance in a patient with renal insufficiencyMiscellaneous antibacterial drugsLinear IgA bullous dermatosisVancomycin-induced linear IgA bullous diseaseLife-Threatening Reaction to Vancomycin Given for Noninfectious FeverVancomycin 15 September 1998Volume 129, Issue 6 Page: 508-509 Keywords Antibiotics Blisters Direct immunofluorescence Drug administration Drugs Neutrophils Skin diseases Surgical repair Vancomycin Vesicles ePublished: 15 August 2000 Issue Published: 15 September 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...