Paraquat Poisoning and Colchicine Treatment
Authors: W. VINCKEN
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 September 1981Paraquat Poisoning and Colchicine TreatmentW. VINCKEN, M.D., L. HUYGHENS, M.D., W. SCHANDEVYL, M.D., D. VERBEELEN, M.D., L. CORNE, M.D.W. VINCKEN, M.D.Search for more papers by this author, L. HUYGHENS, M.D.Search for more papers by this author, W. SCHANDEVYL, M.D.Search for more papers by this author, D. VERBEELEN, M.D.Search for more papers by this author, L. CORNE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-3-391_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Ingestion of even slight quantities of the herbicide paraquat often leads to a fatal outcome within 24 hours due to damage of cell membranes by superoxide ions (O-) with subsequent necrosis of liver, heart, kidneys, and adrenals. The survivor often will develop progressive incapacitating and often fatal respiratory failure within 5 to 10 days, due to diffuse fibrosing alveolitis, with an early "exudative" phase and a subsequent "proliferative" phase leading to alveolar lining cell hyperplasia and interstitial fibrosis.A 32-year-old patient was admitted to the hospital on 22 June 1980, 3 hours after having deliberately ingested 50...References1. OLMSTEADBORISY JG. Microtubules. Ann Rev Biochem. 1973;42:507-40. CrossrefMedlineGoogle Scholar2. HARRISKRANE ES. Effects of colchicine on collagenase in cultures of rheumatoid synovium. Arthritis Rheum. 1971;14:669-84. CrossrefMedlineGoogle Scholar3. ROJKINDKERSHENOBICH MD. Effect of colchicine on collagen albumin and transferrin synthesis by cirrhotic rat liver slices. Biochem Biophys Acta. 1975;378:415-23. MedlineGoogle Scholar4. KERSHENOBICHURIBESUÁREZMATAPÉREZ-TAMAYOROJKIND DMGJRM. Treatment of cirrhosis with colchicine: a double-blind randomized trial. Gastroenterology. 1979;77(3):532-6. CrossrefMedlineGoogle Scholar5. CHUENSUMRANKHURANAVARSHNEYNIDEN OMSA. Effect of colchicine on pulmonary collagen synthesis in vivo. Am Rev Respir Dis. 1977;115(4):315. Abstract. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. VINCKEN, M.D.; L. HUYGHENS, M.D.; W. SCHANDEVYL, M.D.; D. VERBEELEN, M.D.; L. CORNE, M.D.Affiliations: Academic Hospital Free University of Brussels Brussels, Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParaquat and DiquatParaquat and DiquatBipyridyl HerbicidesParaquat induced pulmonary fibrosis in three survivors.Radiotherapy for the Treatment of Pulmonary Complications of Paraquat PoisoningFailure of Haemoperfusion and Haemodialysis to Prevent Death in Paraquat PoisoningPharmacological Treatments of Paraquat PoisoningParaquat lung: is there a role for radiotherapy?MT and MT Poisons in Pathology and Medicine 1 September 1981Volume 95, Issue 3Page: 391-392KeywordsCell proliferationColchicineFibrosisHeartIngestionKidneysLiverNecrosisPulmonary fibrosisRespiratory failure ePublished: 1 December 2008 Issue Published: 1 September 1981 PDF downloadLoading ...