The Nature of the Vascular Lesion in Thrombotic Thrombocytopenic Purpura.
Authors: Hau C. Kwaan
Journal: Annals of Internal Medicine (1968)

s1 May 1968The Nature of the Vascular Lesion in Thrombotic Thrombocytopenic Purpura.Hau C. Kwaan, F.R.C.P.(Edin.), Guillermo Gallo, M.D., Elizabeth Potter, M.D., Hunter Cutting, M.D., F.A.C.P., Robert Stanzler, M.D.Hau C. Kwaan, F.R.C.P.(Edin.)Search for more papers by this author, Guillermo Gallo, M.D.Search for more papers by this author, Elizabeth Potter, M.D.Search for more papers by this author, Hunter Cutting, M.D., F.A.C.P.Search for more papers by this author, Robert Stanzler, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1169_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite evidence of extensive intravascular microthrombi formation in thrombotic thrombocytopenic purpura (TTP), there is absence of defibrination suggesting an unusual type of vascular lesion. Three patients with TTP were studied in an attempt to clarify the nature of these lesions. Tissues were studied by the histochemical fibrin slide method for plasminogen activator and by the immunofluorescent method for fibrinogen, gamma globulin, and B-1-C complement. The plasma was assayed for plasminogen activator, inhibitors of fibrinolysis, fibrinogen, plasminogen, and factors V, VII, VIII, and IX. Characteristic vascular lesions with thrombi formation were seen in all the tissues studied. Immunofluorescent studies revealed bright... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Hau C. Kwaan, F.R.C.P.(Edin.); Guillermo Gallo, M.D.; Elizabeth Potter, M.D.; Hunter Cutting, M.D., F.A.C.P.; Robert Stanzler, M.D.Affiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThrombotic microangiopathy and cytomegalovirus in liver transplant recipients: a case-based reviewPlasminogen activator inhibitor (PAI-1) antigen levels in primary TTP and secondary TTP post-bone marrow transplantationChronic relapsing thrombotic thrombocytopenic purpura and antiphospholipid antibodies: A report of two casesEffectiveness of cryosupernatant therapy in refractory and chronic relapsing thrombotic thrombocytopenic purpuraRapid death from thrombotic thrombocytopaenic purpura following caesarean sectionCoagulation in Renal Diseases: The Role of the Glomerular Hemostasis System and Implications for TherapyThrombotic MicroangiopathyBleeding Disorders in PregnantPatients with Rheumatic Diseases7 Thrombotic Thrombocytopenic Purpura and the Haemolytic-Uraemic Syndrome: Evolving Concepts of Pathogenesis and TherapyObstetric Haemorrhage: Causes and ManagementSimilarities and Differences between the Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic PurpuraPROSTACYCLIN THERAPY OF THROMBOTIC THROMBOCYTOPENIC PURPURAPLASMAPHERESIS IN THE TREATMENT OF THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF FIVE CASESDisseminated intravascular coagulation and related syndromes: Etiology, pathophysiology, diagnosis, and managementArterial thrombosis in sclerodermaPhagocytosis of Blood Cells by Splenic Macrophages in Thrombotic Thrombocytopenic PurpuraA. KADRI, M.D., M. MOINUDDIN, M.D., F.R.C.P.(C), N. K. M. de LEEUW, M.D., F.A.C.P., F.R.C.P.(C)Disseminated Intravascular CoagulationRecognition and treatment of intravascular coagulation 1 May 1968Volume 68, Issue 5Page: 1169-1170KeywordsBlood plasmaFibrinFibrinogenFibrinolysisGlobulinsLesionsThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...