tbuckley/cabot-search huggingface dataset:
Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis
Authors: B Ostendorf
Journal: Annals of the Rheumatic Diseases (2004)

<b>Background:</b> Joint involvement occurs in most patients with systemic lupus erythematosus (SLE), and severe lupus arthritis is often refractory to conventional treatments. Anakinra is used in the treatment of rheumatoid arthritis, but its therapeutic potential has not been proved in patients with SLE. <b>Objective:</b> To determine the safety/tolerability and efficacy of anakinra in patients with SLE with leading joint involvement. <b>Methods:</b> In patients with SLE with active polyarthritis and no other uncontrolled systemic/organ manifestations, 100 mg/day anakinra was self administered subcutaneously for 3 months. Disease activity was assessed by VAS, number of swollen/tender joints, ECLAM score, and serological and immunological measures. Results: Four patients with SLE were studied; anakinra was safe in all four patients and no drug related serious adverse events occurred. A subjective benefit was seen in all patients and a trend towards better activity measures after 4 weeks. After an initial response, one patient left the study because of an arthritic flare after 6 weeks. <b>Conclusion:</b> In this study anakinra was apparently safe and well tolerated and led to clinical and serological improvement. Anakinra might be an interesting alternative in individual patients with lupus arthritis not responding to conventional treatments.
ATTENUATIONS IN TISSUE DOPPLER-DERIVED LEFT VENTRICULAR SYSTOLIC VELOCITY PREDICT AN AMPLIFIED RISK OF LETHAL ARRHYTHMIAS IN ICD RECIPIENTS INDEPENDENTLY OF EJECTION FRACTION
Authors: Mohamad F. Barakat, Omar Chehab, Saj Hayat, Mihir Kelshiker, Hazel Turner, Karl Norrington, Klio Konstantinou, Zachary Whinnett, Michael Koa-Wing, Charlotte Manisty, Ian Wright, Shahnaz Jamil-Copley, Boon Lim, Nilesh Sutaria, Petros Nihoyannopoulos, David Lefroy, Jamil Mayet, Darrel P. Francis, David Wyn Davies, Nicholas Peters, Prapa Kanagaratnam, Darlington O. Okonko
Journal: Journal of the American College of Cardiology (2013)
TUMOR OF THE IRIS.Read in the Section on Ophthalmology, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: J. SCHNEIDER
Journal: JAMA (1893)

Tumors of the iris not caused by infection, such as syphilis or tuberculosis are very rare in our clinical experience, and when seen the majority have arrived at that stage of development when the integrity of the eye has been so changed that in order to arrest farther and more serious consequences there remains but one alternative, that of enucleation. In the literature on the subject I have not been able to find a similar case, and in my personal experience but this one, where after the removal of such a tumor from the iris there has remained useful vision; and in the light of these facts I consider the following case very unique in its clinical and anatomical results: Miss M., of Iron Mountain, Mich., consulted me with reference to a disturbance in the vision of her left eye. On awaking the morning of the 29th of March, 1892,
Zero-for-Three?
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease
Authors: Derek E. Byers, Jennifer Alexander-Brett, Anand C. Patel, Eugene Agapov, Geoffrey Dang-Vu, Xiaohua Jin, Kangyun Wu, Yingjian You, Yael Alevy, Jean-Philippe Girard, Thaddeus S. Stappenbeck, G. Alexander Patterson, Richard A. Pierce, Steven L. Brody, Michael J. Holtzman
Journal: Journal of Clinical Investigation (2013)

Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial and immune cell function that are driven, at least in part, by infection. Analysis of parainfluenza virus infection in mice revealed an unexpected role for innate immune cells in IL-13–dependent chronic lung disease, but the upstream driver for the immune axis in this model and in humans with similar disease was undefined. We demonstrate here that lung levels of IL-33 are selectively increased in postviral mice with chronic obstructive lung disease and in humans with very severe chronic obstructive pulmonary disease (COPD). In the mouse model, IL-33/IL-33 receptor signaling was required for Il13 and mucin gene expression, and Il33 gene expression was localized to a virus-induced subset of airway serous cells and a constitutive subset of alveolar type 2 cells that are both linked conventionally to progenitor function. In humans with COPD, IL33 gene expression was also associated with IL13 and mucin gene expression, and IL33 induction was traceable to a subset of airway basal cells with increased capacities for pluripotency and ATP-regulated release of IL-33. Together, these findings provide a paradigm for the role of the innate immune system in chronic disease based on the influence of long-term epithelial progenitor cells programmed for excess IL-33 production.
Stopping treatment in patients with hypertension.
Authors: M Aylett, S Ketchin
Journal: BMJ (1991)

<h3>Objective</h3> To determine pregnant women and new mothers’ perception of risks in pregnancy. <h3>Design, settings and participants</h3> This was a large-scale multinational survey including 9113 pregnant women and new mothers from 18 countries in Europe, North America and Australia. <h3>Main outcomes</h3> Risk perception scores (0–10) for harmful effects to the fetus were derived for: (1) medicines (over-the-counter medicine and prescribed medicine), (2) food substances (eggs and blue veined cheese), (3) herbal substances (ginger and cranberries) (4) alcohol and tobacco, and (5) thalidomide. <h3>Results</h3> Overall, 80% (6453/8131) of women perceived the risk of giving birth to a child with a birth defect to be ≤5 of 100 births. The women rated cranberries and ginger least harmful (mean risk perception scores 1.1 and 1.5 of 10, respectively) and antidepressants, alcohol, smoking and thalidomide as most harmful (7.6, 8.6, 9.2 and 9.4 out of 10, respectively). The perception varied with age, level of education, pregnancy status, profession and geographical region. Noticeably, 70% had not heard about thalidomide, but of those who had (2692/9113), the risk perception scores were 0.4–0.5 points lower in women below 25 years compared to women aged 26–30 years. <h3>Conclusions</h3> In general, women perceived the risks of giving birth to a child with birth defects low, but there were substantial disparities between women9s perceived risks and the actual risks when it comes to over-the-counter agents against nausea and prescribed medication. The study revealed that few women knew of thalidomide, suggesting that the general awareness among women of the teratogenic effects of thalidomide is declining, but it has left a general scepticism about safety of medication in pregnancy. This may have some severe consequences if women are left without medical treatments in pregnancy.
Multimodality Imaging of a Pancreatic Transplant A Case Report
Authors: BRIAN EISENBERG, MICHAEL G. VELCHIK, WARREN B. GEFTER, LEONARD PERLOFF, DAVID LOW, ABASS ALAVI
Journal: Clinical Nuclear Medicine (1990)

A 41-year-old man who had insulin-dependent diabetes mellitus from the age of 14 underwent cadaveric renal transplant in 1984. Two years later, the patient underwent pancreatic allograft transplantation. The patient did well for eight days after the operation and did not require exogenous insulin. After the eighth day, serum glucose levels rose. Multiple radiologic studies were performed to assess the possibility of graft rejection. A Tc-99m DTPA study revealed a gradual decrease in perfusion, and an ln-111 oxine WBC study showed nonspecific inflammation. CT scanning and MRI displayed postsurgical anatomical relationships and excluded a peripancreatic fluid collection, but were unable to demonstrate parenchymal abnormality of the pancreas. Tests for infection proved negative. Because the decreased blood flow demonstrated by DTPA study indicated transient ischemia, the patient was treated for graft rejection and stabilized quickly.
Gallbladder Carcinoma Metastasizing to Adrenal Gland
Authors: Manas Kumar Sahoo, Punit Sharma, Sudhir Suman, Tarun Kumar Jain, Chandrasekhar Bal, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2013)

Adrenal metastases have commonly been reported in a wide variety of cancers but not in gallbladder cancer. We here present a case of a 45-year-old male patient with gallbladder carcinoma where left adrenal metastasis was detected on staging 18F-FDG PET/CT. This was confirmed histopathologically. 18F-FDG PET/CT can have a significant impact on management of patients with gallbladder carcinoma by demonstrating rare sites of metastasis.
313 HYDROXIZYNE IMPROVED INSOMNIA IN CIRRHOTIC INPATIENTS WITH GRADE I ENCEPHALOPATY
Authors: S. Soto, E. Castro, J.L. Ulla, S. Vazquez, R. Baltar, V. Alvarez, J. Vazquez-Sanluis, L. Ledo, E. Vazquez-Astray
Journal: Journal of Hepatology (2008)
Atrial supply–demand balance in healthy adult pigs: coronary blood flow, oxygen extraction, and lactate production during acute atrial fibrillation
Authors: Kelly A. van Bragt, Hussein M. Nasrallah, Marion Kuiper, Joost J. Luiken, Ulrich Schotten, Sander Verheule
Journal: Cardiovascular Research (2013)

Little is known about how atrial oxygen supply responds to increased demand, and under which conditions it falls short (supply-demand mismatch). Here, we have investigated the vasodilator response, oxygen extraction, and lactate production of the left atrium (LA) and left ventricle (LV) in response to atrial pacing and atrial fibrillation (AF).Series A (n = 9 Dutch landrace pigs) was instrumented to measure LA and LV vascular conductance in branches of the circumflex artery. Coronary conductance reserve (CCR) was calculated as the ratio between conductance during adenosine infusion and baseline. Series B (n = 7) was instrumented with sampling catheters in LA and LV veins for determination of blood gases and lactate levels. LA CCR (1.76 ± 0.14) was significantly lower than LV CCR (3.16 ± 0.27, P = 0.002). However, basal oxygen extraction was lower in LA (27 ± 3%) than that in the LV (58 ± 6%, P = 0.0006), indicating a larger extraction reserve in the LA than that in the LV (4.68 ± 0.84 vs. 1.88 ± 0.26, P = 0.01). Atrial pacing caused an increase in LA conductance (Series A) and oxygen extraction (Series B). AF increased LA vascular conductance to 177 ± 14% at 1 min, 168 ± 14 at 5 min, and 164 ± 31% at 10 min of AF (P < 0.05 vs. baseline). Atrial oxygen extraction also increased from 26 ± 3% at baseline to 63 ± 5% (P < 0.01) at 5 min and 60 ± 11% (P < 0.01) at 10 min of AF. Arterio-venous lactate difference increased significantly (P = 0.02) during AF.In healthy pigs, the LA has a lower CCR, but a higher extraction reserve compared with the LV. Although both reserves were recruited during AF, atrial lactate production increased significantly.
The practice brochure: a patient's guide to team care.
Authors: G N Marsh
Journal: BMJ (1980)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to be a global challenge due to resulting morbidity and mortality. Cardiovascular (CV) involvement is a crucial complication in COVID-19, and no strategies are available to prevent or specifically address CV events in COVID patients. The identification of molecular partners contributing to CV manifestations in COVID-19 patients is crucial for providing early biomarkers, prognostic predictors and new therapeutic targets. The current report will focus on the role of miRNAs in CV complications associated with COVID-19. Indeed, miRNAs have been proposed as valuable biomarkers and predictors of both cardiac and vascular damage occurring in SARS-CoV-2 infection. <b>Significance Statement</b> It is essential to identify the molecular mediators of COVID-19 cardiovascular (CV) complications. This report focused on the role of miRNAs in CV complications associated with COVID-19, discussing their potential use as biomarkers, prognostic predictors, and therapeutic targets.
FDA panel advises easing restrictions on rosiglitazone
Authors: M. E. Tucker
Journal: BMJ (2013)

A joint Food and Drug Administration advisory panel has voted to ease the current stringent restriction on prescription of the antidiabetes drug rosiglitazone (marketed by GlaxoSmithKline as Avandia), despite lingering concerns about its cardiovascular safety.

The three year old restrictions, formally known as a “risk evaluation and mitigation strategy (REMS) with elements to assure safe use (ETASU) program,” called for certification of the physician and the dispensing pharmacy and for medication guides for patients and physicians.1 They also limited the drug’s use to patients who were already taking it before the restrictions were placed and to patients for whom no other glucose lowering agents are acceptable.

The vote took place on the second day of a two day joint meeting of the FDA’s endocrinologic and metabolic drugs advisory committee and its drug safety and risk management advisory committee. The vote was split, with just half of the total of 26 members opting to keep …
Reforming the Core Clerkship in Internal Medicine
Authors: Allan H. Goroll
Journal: Annals of Internal Medicine (2001)

Letters16 October 2001Reforming the Core Clerkship in Internal MedicineAllan H. Goroll, MDAllan H. Goroll, MDMassachusetts General Hospital; Boston, MA 02114 (Goroll)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-8_Part_1-200110160-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our original manuscript listed interpretation of electrocardiography, not echocardiography, as a basic generalist competency. “Electrocardiography” was inadvertently changed to “echocardiography” when Table 1 was reconstructed for publication, and this error was not corrected during reading of the proofs. It would be a bit much to expect third-year students to be proficient in echocardiography! They have enough to learn. Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital; Boston, MA 02114 (Goroll) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReforming the Core Clerkship in Internal Medicine: The SGIM/CDIM Project Allan H. Goroll , Gail Morrison , Eric B. Bass , Robert Jablonover , Dionne Blackman , Roger Platt , Alison Whelan , and Francine P. Hekelman Reforming the Core Clerkship in Internal Medicine A. Sidney Barritt III Reforming the Core Clerkship in Internal Medicine A. Sidney Barritt III Metrics Cited ByNecrotizing Fasciitis in Paroxysmal Nocturnal Hemoglobinuria 16 October 2001Volume 135, Issue 8_Part_1Page: 635KeywordsEchocardiographyElectrocardiography ePublished: 16 October 2001 Issue Published: 16 October 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Comparison of Grenz rays versus placebo in the treatment of chronic hand eczema
Authors: P.H. CARTWRIGHT, N.R. ROWELL
Journal: British Journal of Dermatology (1987)

A double-blind trial was performed on 30 patients with bilateral symmetrical constitutional hand eczema, resistant to previous treatment. There was no difference in efficacy between Grenz rays in a total dose of 900 rad (9 Gy) given in three equal doses at 21-day intervals, and placebo therapy given in a similar treatment schedule.
Carcinoma of Bronchus in Association with Active Pulmonary Tuberculosis
Authors: A. Sakula
Journal: BMJ (1955)

OSTEOARTHROPATHY AND CARCINOMA MEDICALJOURNAL 7tumour and urine extracts, vascular studies of resected lungs, and autonomic block are all possible keys to the solution of this fascinating problem.Summary Bronchial carcinoma may now be regarded as the chief cause of generalized hypertrophic pulmonary osteoarthropathy.A review of 24 patients with this syndrome encountered during the past seven years is pr-esented.The pathogenesis of osteoarthropathy has been reviewed in the light of our clinical studies, past experimental work, and the dramatic and invariable "cure" effected by tumour removal.Such patients are often treated for rheumatism or rheumatoid arthritis for many months, and may become bedridden cripples before the presence of a silent lung tumour is suspected.Fifteen of the patients were submitted to lung resec- tion.Only four are alive.Operative results in this type of tumour might be expected to improve when the significance of such joint symptoms becomes more generally appreciated.We wish to thank Mr. Bruce Dick for his ever-helpful co-
Cardiac transplantation: recipient selection, donor procurement, and medical follow-up. A statement for health professionals from the Committee on Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association.
Authors: J B O'Connell, R C Bourge, M R Costanzo-Nordin, D J Driscoll, J P Morgan, E A Rose, B F Uretsky
Journal: Circulation (1992)
Vascular Disease in Progressive Systemic Sclerosis (Scleroderma)
Authors: WALTER L. NORTON
Journal: Annals of Internal Medicine (1970)

Not only is the cause of progressive systemic sclerosis unknown, but there is no general agreement on the point of pathological impact. However, clinical, morphological, and functional observations provide a consistent body of evidence indicating widespread vascular abnormalities in the disease. Although characteristic arterial lesions have been recognized for many years, their frequency has generally been considered to be insufficient to account for the varied manifestations of progressive systemic sclerosis. Recent evidence suggests that the capillary bed may be a primary site of injury, and diffuse devascularization of multiple tissues may be a major consequence. On the basis of evidence reviewed, progressive systemic sclerosis should be classified as a vascular disease, and the primary site of injury is at the microvascular level.
Limited joint mobility in children and adolescents with insulin dependent diabetes mellitus.
Authors: C F Clarke, A T Piesowicz, G S Spathis
Journal: Annals of the Rheumatic Diseases (1990)

Joint mobility was studied in 70 children with insulin dependent diabetes mellitus aged 8-17 years, and the prevalence of limited joint mobility (LJM) was found to be 31% (22/70). This figure fell to only 7% (5/70) when an alternative method of assessment was used. A high number of non-diabetic, non-sibling controls (6/51 (12%] were found to have LJM. There was a trend towards an increasing prevalence of LJM with increasing age and duration of diabetes, but it was also found in patients with recent onset diabetes. A large proportion of prepubertal patients were noted to have LJM. No correlation was found between LJM and either short stature or diabetic control. There is a need for standardisation of the methods used to define and stage LJM in diabetic patients, and the significance of this clinical finding remains unclear.
Antiplasmin concentrations after surgery: failure of alpha 2-antiplasmin to rise in patients with venous thrombosis.
Authors: D A Taberner, L Poller, R W Burslem
Journal: BMJ (1979)

since adequate respiration took several days to return, respiration was supported artificially.Hypertension and tachycardia did not recur.Recovery was gradual but uneventful.He was discharged 35 days after admission. CommentLabetalol was effective in controlling the circulatory effects of adrenergic stimulation from tetanus in this patient, and may be more advantageous than other forms of management using either alphaor beta-adrenergic blocking drugs.Continuous infusion, although expensive, ensures a reasonably sustained effect and offers a practical alternative to intermittent intravenous or oral administration.Never- theless, decurarisation should be performed cautiously and adequate doses of atropine must be given.This regimen merits further study.
THE PRODUCTION IN DOGS OF CHRONIC BLACK TONGUE WITH ANEMIA
Authors: C. P. Rhoads, D. K. Miller
Journal: The Journal of Experimental Medicine (1933)

1. By the feeding of a particular diet, apparently lacking a substance closely associated with vitamin B(2) G, a chronic disease may be produced irregularly in dogs. 2. The disease is characterized by atrophic glossitis, diarrhea, loss of weight, and anemia. 3. The disease can be prevented and relieved by materials rich in vitamin B(2) G.
THE TREATMENT OF ADENOID VEGETATIONS OF THE NASOPHARYNX.
Authors: OTTO T. FREER
Journal: JAMA (1900)

Medical treatment usually is ineffective as far as reduction of the growths is concerned, but as there is often an undoubted connection between lymphoid enlargements in childhood and future tuberculosis of the lung, much can be done to prevent this by general means. The surgical treatment of adenoid vegetation is the one to be considered, therefore, and the first subject that presents itself is whether it is better to employ general anesthesia in operations for removal of the hypertrophied pharyngeal tonsil or not. The advantages of operation without anesthesia are avoidance of the dangers of enforced insensibility, the fact that the operation loses much of its formidable appearance to the child's parents, and the absence of the disagreeable after-effects of anesthesia. The objections to operation without an anesthetic are many. The first is the pain inflicted. It is comfortable for the operator to imagine that the nasopharynx is not especially