tbuckley/cabot-search huggingface dataset:
A synthetic cantharidin analog for the enhancement of doxorubicin suppression of stem cell-derived aggressive sarcoma
Authors: Chao Zhang, Yi Peng, Fengchao Wang, Xu Tan, Nan Liu, Song Fan, Dechun Wang, Lilong Zhang, Dengqun Liu, Tao Wang, Shaojun Wang, Yue Zhou, Yongping Su, Tianmin Cheng, Zhengping Zhuang, Chunmeng Shi
Journal: Biomaterials (2010)
Getting an Edge — Use of Stimulants and Antidepressants in College
Authors: Richard Kadison
Journal: New England Journal of Medicine (2005)

A college student sought help at our health center because he was having social anxiety and difficulty participating in class discussion. He said he had used an antidepressant drug to combat his social fears when he was in high school but had stopped taking it because he wanted to make a fresh start in college — and because he'd noticed that the medication affected his libido. Now, however, because he was painfully aware that class participation counted for half his grade, he wanted a new prescription for his old medication.Around the same time, I saw another student who, he . . .
Training in family planning encompasses several disciplines
Authors: A M C Webb, M Kishen
Journal: BMJ (1995)

ways, one would, strictly speaking, need hundreds of thousands of randomised trials to arrive at conclusive answers about the efficacy of this form of treatment.Clearly, this is not practical.The Centre for Complementary Health Studies is therefore planning a trial designed to answer the much broader question, "does homoeopathy work (regardless of remedy, dose, etc)?"I would be delighted to hear from potential participants in this multicentre study.EERNST
Death from vertebral artery thrombosis in rheumatoid arthritis.
Authors: F. W. Webb, J. A. Hickman, D. S. Brew
Journal: BMJ (1968)

the pig by Mayer in 1825 and by Bang in 1876 in a female patient who died of volvulus.It was reported in the living by Hahn in 1899.Since then there have been a number of reports, mostly of single cases, but Doub and Shea (1960) described 16 cases in their practice.Despite those records the natural history is badly docu- mented.Jones (1948) described a case in which laparotomy had shown no cysts.Two and a half years later repeated laparotomy showed pneumatosis of the colon and mesentery.Griffiths (1955) described a case in which laparotomy in 1946 showed no cysts; colonic symptoms began one year later-for example, blood and mucus per rectum-and gradually increased, and by 1949 the condition was demonstrated by sigmoidoscopy and x-ray examination.The present patient was probably free of cysts in 1959 (though only a part of the colon was shown on barium studies) but had gross disease in 1962.It would therefore seem that the disease is fairly slow in developing, which is supported by the gross enlargement of the colon in established cases.The subsequent history is also badly documented.Koss (1952) stated that " there is considerable evidence that the cysts may disappear spontaneously," and cited a number of authors, but these all appear to be cysts of the small intestine.Doub and Shea (1960) described 16 cases of colonic involvement without complications and stated that the cysts may regress, but gave no long follow-up.The case described above resolved symptomatically in one year and completely in five years.
The Greater Rock of Ages Baptist Church
Authors: Anne L. Peters
Journal: Annals of Internal Medicine (1999)

On Being a Doctor6 July 1999The Greater Rock of Ages Baptist ChurchAnne L. Peters, MDAnne L. Peters, MDUniversity of California, Los Angeles, School of Medicine; Los Angeles, CA 90095-1693 (Peters)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-1-199907060-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I work in a busy hospital-based clinic, staffed by a large but competent and consistent group of secretaries, nurses, clerks, and other personnel. When the fiancé of one of the scheduling clerks was killed in an automobile accident, I felt obliged to attend his memorial service. Betty, the employee, was approximately my age, in her late 30s. Although she sometimes seemed overwhelmed by the needs of scheduling (and rescheduling) our many patients, she was always kind and helpful. I knew nothing of her personal life but was told that she had two sons from a previous relationship and had known ... Author, Article, and Disclosure InformationAuthors: Anne L. Peters, MDAffiliations: University of California, Los Angeles, School of Medicine; Los Angeles, CA 90095-1693 (Peters)Corresponding Author: Anne L. Peters, MD, 200 UCLA Medical Plaza, Suite 365, Los Angeles, CA 90095-1693. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 July 1999Volume 131, Issue 1Page: 66-67KeywordsAgingChildrenFearHeartMemoryRacial and ethnic issuesSafety ePublished: 15 August 2000 Issue Published: 6 July 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Irish face flood of compensation claims
Authors: D. Payne
Journal: BMJ (1998)

The Irish government's ongoing battle with serving and former soldiers is going from bad to worse. Compensation claims for deafness relating to inadequate hearing protection before 1987 continue to pour in; almost 12000 have already been lodged, and as many as 600 new claims are being put in every month.

Compensation settlements and costs were at one point averaging £Ir37000 (£31000; $49600) each. A report from the Public Accounts Committee said that if only 10% of …
Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: Two‐year results including pharmacokinetics and concomitant hydroxyurea
Authors: Elliott Vichinsky, Marcela Torres, Caterina P. Minniti, Stephane Barrette, Dany Habr, Yiyun Zhang, Beatrice Files
Journal: American Journal of Hematology (2013)

We report a prospective, randomized, Phase II study of deferasirox and deferoxamine (DFO) in sickle cell disease patients with transfusional iron overload, with all patients continuing on deferasirox after 24 weeks, for up to 2 years. The primary objective was to evaluate deferasirox safety compared with DFO; long‐term efficacy and safety of deferasirox was also assessed. We also report, for the first time, the safety and pharmacokinetics of deferasirox in patients concomitantly receiving hydroxyurea. Deferasirox ( n = 135) and DFO ( n = 68) had comparable safety profiles over 24 weeks. Adverse events (AEs) secondary to drug administration were reported in 26.7% of patients in the deferasirox cohort and 28.6% in the DFO cohort. Gastrointestinal disorders were more common with deferasirox, including diarrhea (10.4% versus 3.6%) and nausea (5.2% versus 3.6%). The most common AE in the DFO group was injection‐site pain irritation, which occurred in 7% of patients. Acute renal failure occurred in one patient on deferasirox who was continued on medication despite progressive impairment of renal function parameters. Serum ferritin levels were reduced in both treatment groups. Patients continuing on deferasirox for up to 2 years demonstrated an absolute median serum ferritin decrease of −614 ng/mL ( n = 96). Increasing deferasirox dose was associated with improved response and a continued manageable safety profile. Concomitant hydroxyurea administration ( n = 28) did not appear to influence the efficacy, safety (including liver and kidney function), and pharmacokinetic parameters of deferasirox. Am. J. Hematol. 88:1068–1073, 2013. © 2013 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.
UPLC–MS/MS for the determination of azilsartan in beagle dog plasma and its application in a pharmacokinetics study
Authors: Cheng Gong, Junfeng Wang, Yinghua Sun, Dawei Ding, Lu Zhong, Meng Zhu, Jin Sun, Xiangrong Zhang
Journal: Asian Journal of Pharmaceutical Sciences (2014)

The purpose of the study is to develop an ultra performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) to determinate the concentration of azilsartan in the dog plasma. After precipitated by methanol, the plasma sample containing azilsartan and diazepam (internal standard, IS) was determined by UPLC–MS/MS. The mobile phase consisted of acetonitrile-water was pumped at a flow rate of 0.3 ml/min in gradient elution. Kinetex 2.6 μ XB-C18 column (50 × 2.1 mm, 100 Å; Phenomenex, USA) were used for LC separations. The column temperature was 30 °C and the injection volume was 5 μl. The electrospray ionization (ESI) and multiple reaction monitoring (MRM) were applied at the transitions of m/z 457 → 279 (azilsartan) and m/z 285 → 193 (diazepam), respectively. The developed method was identified a good linearity over a concentration range of 2.5–5000 ng/ml. The lower limit of quantitation (LLOQ) was 2.5 ng/ml. The intra-day and inter-day precision (relative standard deviation, RSD%) were less than 10% and accuracy (relative error, RE %) was less than 5% at three quality control levels. The extraction recovery of azilsartan at three quality control levels were 82.41 ± 0.68%, 98.66 ± 11.00%, 102.43 ± 0.82%. And the recovery for IS (100 ng/ml) was 91.75 ± 0.54%. A validated UPLC–MS/MS method was firstly developed for the quantification of azilsartan in dog plasma and it was applied to the pharmacokinetics study.
941-20 Safety of Cardiac Biopsy Based on the 32-year Experience in Japan
Authors: Shinya Hiramitsu, Michiaki Hiroe, Shin-ichiro Morimoto, Kenji Yamada, Akihisa Uemura, Natsuko Kubo, Katsutomo Kimura, Fumiaki Marumo, Yoshihiko Watanabe, Hitoshi Hishida
Journal: Journal of the American College of Cardiology (1995)
Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule.
Authors: R Dalchau, J W Fabre
Journal: The Journal of Experimental Medicine (1981)

Initial studies with the monoclonal antibody F8-11-13 described in this paper showed that it reacted strongly with B lymphocytes, did not react at all with granulocytes, and reacted only weakly with a small subpopulation of thymocytes and peripheral T lymphocytes. This picture was entirely different from that seen with monoclonal antibodies to the leukocyte common (LC) antigen, where 100% of all the above-mentioned leukocyte populations were positive. Biochemical studies using detergent solubilized membranes labeled with 3H at the sialic acid residues showed that the molecule bearing the F8-11-13 determinant was a glycoprotein of 215,000 mol wt, and that the peak depleted by F8-11-13 monoclonal antibody affinity columns corresponded to the high molecular weight region of a broad peak previously shown to be completely depleted by monoclonal antibody (F10-89-4) affinity columns directed at the LC antigen. Proof that the F8-11-13 determinant was expressed on some LC molecules was established by cross-inhibition studies with affinity-column-purified and depleted material. This finding of a serologically identifiable conformational or other structural change selectively expressed on the LC molecule of a functionally discrete population of lymphocytes has interesting implications for the structure and function of the LC molecule, and might be relevant to functional consideration of other membrane molecules.
Congenital thrombotic disorders
Authors: George M. Rodgers, Marc A. Shuman
Journal: American Journal of Hematology (1986)

Abstract The investigation of kindreds with recurrent thrombotic disease has advanced the understanding of the mechanisms of coagulation and fibrinolysis. In those cases where an etiology has been established, congenital thrombotic disorders are associated either with deficiencies or qualitative abnormalities in inhibitors of activated coagulation factors, qualitative abnormalities of fibrinogen, fibrinolytic defects that impair clot lysis, or an inborn error of metabolism, homocystinuria. The etiologies of congenital thrombotic disorders, their clinical features, and an approach to their laboratory diagnosis are summarized in this review.
An effective conscious animal model of atrial fibrillation
Authors: J. R. WHITTINGTON, M. R. CROSS, E. B. RAFTERY
Journal: Cardiovascular Research (1979)

In 11 fully conscious dogs with chronically implanted epicardial electrodes, 50 Hz sine-wave electrical stimulation of the left atrium reliably and repeatedly produced an arrhythmia which was indistinguishable from atrial fibrillation in terms of its ECG appearance, the statistical properties of the ventricular response and responses to a number of pharmacological agents. In five of the 11 preparations this arrhythmia consistently persisted for periods in excess of 10 min following the cessation of stimulation, indicating an intrinsic cardiac basis for the arrhythmia and suggesting that it is true atrial fibrillation. A close correlation between the ventricular response to this arrhythmia and the degree of atrioventricular conductivity, together with the observation that dramatic changes can occur in ventricular responses without corresponding changes in atrial activity, suggest that the ventricular response is mainly a function of the atrio-ventricular conducting system. The experimental model described is useful for the study of both short and long term drug action no atrial fibrillation and for the evaluation of methods used therapeutically in attempts to terminate episodes of paroxysmal atrial fibrillation.
Corrigendum to “Diagnosis and management of acute kidney injury in patients with cirrhosis: Revised consensus recommendations of the International Club of Ascites” [J Hepatol 2015;62:968–974]
Authors: Paolo Angeli, Pere Ginès, Florence Wong, Mauro Bernardi, Thomas D. Boyer, Alexander Gerbes, Richard Moreau, Rajiv Jalan, Shiv K. Sarin, Salvatore Piano, Kevin Moore, Samuel S. Lee, Francois Durand, Francesco Salerno, Paolo Caraceni, W. Ray Kim, Vicente Arroyo, Guadalupe Garcia-Tsao
Journal: Journal of Hepatology (2015)
Ophthalmic surgical training
Authors: A. R Fielder, P. Murray, A. Gibson, M. Watson, M. Moseley, M. Boulton
Journal: Journal of the Royal Society of Medicine (2004)

We respond to Richard Smith's observations (June 2004 JRSM) in relation to our study1 of surgical training amongst ophthalmic senior house officers (SHOs). At the outset, we too expected SHOs in district general hospitals (DGHs) to gain more surgical experience than those in teaching hospitals but found that the proportion of year 3 and 4 SHOs that met the College requirement to be achieved by the end of year 2 (50 completed phako operations) was 36.8% in DGHs and 46.4% in teaching hospitals. Our cross-sectional survey does not allow us to test his suggestion that SHOs in teaching hospitals perform more phako procedures because they have more surgical experience. However, our data do show that, amongst SHOs in their second year of training, those in a teaching hospital perform more phako procedures per week than those in a DGH. This is most striking when gender is taken into account: the year-2 woman SHO in a DGH fares very badly compared with her male counterpart in a teaching hospital—mean number of phakos performed per week 0.44 and 1.20, respectively. Most year-1 SHOs do work in a DGH (96 of 112 respondents), but we are unable to comment on how they move from the DGH to teaching hospital. Richard Smith's suggestion that teaching hospitals somehow manage to cream off a surgically-elite group of SHOs in the second year is intriguing.

No doubt there are a number of ways of ensuring that a trainee surgeon's surgical experience is protected, and Richard Smith offers one simple method of quantifying this. With the anticipated reduction in time for surgical training this is an important debate,2 and one that is justifiably attracting considerable attention in the medical press.3
Hand-to-hand combat, or mouth-to-mouth resuscitation?
Authors: Michael C. Corballis
Journal: Behavioral and Brain Sciences (2003)

Many commentators have raised issues concerning the idea that language evolved from manual gestures. I deal with these first, reiterating the points that speech is very different from animal vocal calls, and that cortical control over manual action provided the best platform for the evolution of intentional communication and language. I then deal with commentaries on the origins of handedness. The critical questions are whether there is indeed an evolutionary coupling between handedness and lateralized control of speech, and if there is, whether a prior lateralization of vocal control provided the nudge that gave most of us left-sided speech and right-handedness.
Taurodeoxycholate activates potassium and chloride conductances via an IP3-mediated release of calcium from intracellular stores in a colonic cell line (T84)
Authors: D C Devor, M C Sekar, R A Frizzell, M E Duffey
Journal: Journal of Clinical Investigation (1993)

Whole-cell patch-clamp techniques and fluorescence measurements of intracellular Ca2+ concentration, (Ca2+)i, were used to investigate the mechanism of taurodeoxycholate (TDC) stimulation of Cl- secretion in the T84 colonic cell line. During perforated whole-cell recordings, the cell membrane voltage was alternately clamped to EK and ECl. Initially, TDC (0.75 mM) stimulated inward nonselective cation currents that were composed of discrete large conductance single-channel events. This initial response was followed by activation of K+ and Cl- currents with peak values of 385 +/- 41 pA and 98 +/- 28 pA, respectively (n = 12). The K+ and Cl- currents oscillated while TDC was present and returned to baseline levels upon its removal. The threshold for activation of the oscillatory currents was 0.1 mM TDC. Taurocholate, a bile acid that does not stimulate colonic Cl- secretion, induced no current response. The TDC-induced currents could be activated in Ca(2+)-free bathing solutions. Preincubation of cells with the Ca2+ chelator, bis-(o-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, tetra(acetoxymethy)-ester (20 microM), (BAPTA-AM), eliminated the K+ and Cl- current responses, although the nonselective cation channel events were still present. Replacement of bath Na+ with NMDG+ inhibited the TDC-induced nonselective cation current but did not affect the K+ or Cl- currents. TDC induced a transient (Ca2+)i rise of 575 +/- 70 nM from a baseline of 71 +/- 5 nM (n = 15); thereafter, (Ca2+)i either plateaued or oscillated. TDC-induced (Ca2+)i oscillations were observed in the absence of bath Ca2+; however, removal of bath Ca2+ during the TDC response caused (Ca2+)i to return to near baseline values. Simultaneous K+ current and (Ca2+)i measurements confirmed that the initial nonselective cation current was independent of (Ca2+)i, while K+ current oscillations were in phase with the (Ca2+)i oscillations. TDC induced inositol monophosphate (IP) accumulation, reflecting production of inositol 1,4,5-trisphosphate (IP3) during TDC stimulation. The response to TDC during standard whole-cell patch-clamp was similar to that observed with perforated whole-cell recordings, except the nonselective cation current was prolonged. When heparin (1 mg/ml) was added to the pipette under these conditions, the Ca(2+)-activated currents were inhibited, but the nonselective cation currents were unaffected. These data suggest that TDC induces a Ca(2+)-independent nonselective cation conductance, perhaps by directly permeabilizing the plasma membrane. TDC stimulates Cl- secretion by activating K+ and Cl- conductances via an IP3-mediated release of Ca2+ from intracellular stores.
Immune reconstitution after haploidentical hematopoietic cell transplantation: impact of reduced intensity conditioning and CD3/CD19 depleted grafts
Authors: B Federmann, M Hägele, M Pfeiffer, S Wirths, M Schumm, C Faul, W Vogel, R Handgretinger, L Kanz, W A Bethge
Journal: Leukemia (2010)
Scientists cultivate stem cells in the laboratory
Authors: S. Gottlieb
Journal: BMJ (1998)

Scientists have achieved a major breakthrough in efforts to culture human cells, with this week's publication of the first successful harvesting of stem cells from human embryos and their culture in the laboratory. The step opens up the possibility of using stem cells to grow a wide variety of other types of cell that make up the human body.

For more than 15 years scientists around the world have been exploring the unique qualities of pluripotent stem cells, which form within days after an egg is fertilised by a sperm and begin multiplying to become an embryo. These cells possess …
Early Diagnosis of Calcinosis Cutis in Childhood Dermatomyositis Using Computed Tomography
Authors: Henry W. Randle, Hans M. Sander, Kim Howard
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We report a case in which soft-tissue calcinosis was demonstrated with computed tomographic (CT) scanning after unsuccessful visualization with plain roentgenograms. <h3>Report of a Case.—</h3> An 11-year-old black girl with dermatomyositis was treated at the Scott and White Clinic in Temple, Tex, for five years. In the fall of 1981 she had developed proximal muscle weakness, adenopathy, polyarticular arthritis, low-grade fever, and skin lesions consisting of numerous atrophic violaceous papules on the knuckles of both hands (Gottren's papules) and a heliotrope rash of the periorbital region. The diagnosis of dermatomyositis was confirmed with an elevated creatine kinase level of 292 units/L (292 U/L) and a muscle biopsy in January 1982 that showed chronic inflammatory changes and perivascular deposition of IgG. Between January 1982 and June 1983 she was treated with prednisone, 10 to 40 mg/d, with moderate improvement in her muscle weakness. In June 1983 she began
Prevention of restenosis of central venous stricture after percutaneous transluminal angioplasty and endovascular stenting by brachytherapy
Authors: Francis Kim-Ming Wong, Philip Chong-Hei Kwok, Roger Kai-Cheong Ngan, Raymond Ka-Yan Wong, Kan-Wong Wong, Susan Chan, Ka-Foon Chau, Chun-Sang Li
Journal: Kidney International (1999)
Studies Utilizing the Portable Electromagnetic Ballistocardiograph
Authors: HARRY MANDELBAUM, ROBERT A. MANDELBAUM
Journal: Circulation (1954)

The ballistocardiograph records the vigor of cardiac ejection and the speed of diastolic filling. It provides a practical means of studying the physiologic response of the heart in its adjustment to the stress of exercise. The application of the light ballistocardiographic exercise test to subjects without clinical or electrocardiographic evidence of heart disease, to hypertensive subjects, to patients with coronary artery disease and to those suspected of having myocarditis has provided information of clinical importance which cannot be obtained from any other means of physical diagnosis or from the ballistocardiogram at rest.
Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects
Authors: Sonja D. Zuijdgeest-van Leeuwen, J.Willem O. van den Berg, J.L.Darcos Wattimena, Ate van der Gaast, G.Roelof Swart, J.H.Paul Wilson, Pieter C. Dagnelie
Journal: Metabolism (2000)