tbuckley/cabot-search huggingface dataset:
Ear, Nose and Throat and Head and Neck Surgery
Authors: R S Dhillon, C A East
Journal: BMJ (1994)

It is ironic that I, the author of a BMJ paperback on this subject, directed at the same readership of medical students, general practitioners, and nursing staff, should be asked to review Ear, Nose and Throat and Head and Neck Surgery, which will clearly be a competitor. The unworthy hope that it might be exposed as a poor imitation, vulnerable to a destructive review, was fleeting and rapidly disappeared as I saw how …
ANALYSIS OF THIRTY-SEVEN CASES OF UVEITIS.
Authors: HIRAM WOODS
Journal: JAMA (1902)

The form of uveitis I propose to consider is choroidocyclitis. The cases, with two exceptions, were seen in private practice. They divide themselves naturally into those with and without descemetitis. This was found in twenty of my thirty-seven cases: two of serous iritis and eighteen of choroiditis with descemititis. The closest description I have found in text-books of this form of choroiditis is by A. Hill Griffith in Norris' and Oliver's "System." Under the heading "Anomalous Forms" he describes a "Choroiditis with Descemetitis." He had seen forty or fifty cases, chiefly in young women. His explanation of the descemetitis is: "The dots on Descemet's membrane are formed in the choroid, set free in the vitreous and carried by the nutrient currents of the eye to be deposited on the back of the cornea, which view necessitates the permeability of the suspensory ligament by solid particles." As to causation, syphilis was
A kinetic study on functional impairment of nitric oxide-exposed rat erythrocytes.
Authors: N Maeda, K Imaizumi, K Kon, T Shiga
Journal: Environmental Health Perspectives (1987)

In acute in vivo exposure of rats to 25 to 250 ppm nitric oxide (NO) by use of a small exposure chamber for a single rat, the kinetic parameters of nitrosylhemoglobin (Hb-NO) and methemoglobin (MetHb) formation were estimated (with the aid of computer simulation) on the basis of experimental data. The biochemical and rheological injuries of erythrocytes were also examined. The time course of Hb-NO and MetHb formation in blood was compared with that simulated by a simplified kinetic model. The rate of MetHb formation from Hb-NO was much faster than MetHb reduction to ferrous form and dissociation of Hb-NO; thus, MetHb content was always greater than Hb-NO content. The activity of MetHb reduction decreased on exposure to a high concentration of NO, but the activity was recovered when rats were placed in clean air. Rheologically, the blood viscosity was scarcely altered, but a few undeformed cells were detected at high shear stress. Morphologically, echinocytic transformation was observed to some extent. Biochemically, the crosslinking of membrane proteins and the alteration of acyl chain composition of membrane phospholipids were not detected in the in vivo exposure, though the in vitro exposure of rat erythrocytes to high concentrations of NO revealed remarkable oxidative crosslinking among membrane proteins and hemoglobin. In conclusion, both for persistent methemoglobinemia and for membrane damage, the maintenance of reductive activity in erythrocytes is the most important determinant factor for the protection of NO-induced oxidative injury.
No Change Indicated in Traffic Fatality Rate
Authors: Phil Gunby
Journal: JAMA (1987)

THE NATION'S traffic fatality rate remains slightly less than 2.5/100 million miles driven. At least, that is the indication from preliminary calculations (for 1986) of a Department of Transportation agency. The department's National Highway Traffic Safety Administration says that, at this point, data suggest the 1986 rate "has remained about the same" as the 2.47/100 million miles recorded in the United States during 1985. There appear to have been about 2200 more deaths in 1986—an approximate 5% increase over the 43 795 recorded in 1985—but the agency says the number of miles driven rose in proportion, so that the fatality rate is unlikely to change. Some other industrialized nations report similar increases in actual number of traffic fatalities for 1986, the agency says, citing France (4.9%), West Germany (6.5%), Britain (4.5%), and Sweden (4.5%). Nonetheless, it says, 2.47/100 million vehicle miles in the United States "is the lowest fatality rate
Meditation Lesson in the Pays d’Oc
Authors: Patrick L. Clary
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE OPERATIVE TREATMENT OF PTERYGIUM.
Authors: EDUARD BOECKMANN
Journal: JAMA (1897)

It is a pleasure to me to have the opportunity of directing the attention of the Mississippi Valley Medical Association to an operative procedure for pterygium which I have employed for nearly fifteen years with eminent satisfaction and of which I gave a preliminary description in the<i>Medicinsk Revue</i>, September, 1885, published in Bergen, Norway. My original operation has in the course of time undergone some modifications, and as I can not, for the time being, conceive of any further improvement, I thought it might be of interest to present it to the medical public at large, and I have chosen this opportunity for the following reasons: Pterygium is of frequent occurrence in the Mississippi Valley. The members of the Association are undoubtedly, from personal experience, familiar with this characteristic affliction and many of you without doubt have treated it surgically in the capacity of oculists, surgeons, or general practitioners.
Environment--a new key area for Health of the Nation?
Authors: A. Walker
Journal: BMJ (1996)

Later this month the government will be consulting on whether the environment should be adopted as a new key area for their Health of the Nation strategy.It is proposing to have five topic areas and to adopt 10-15 environmental targets.This would reaffirm its commitment to linking environmental policy and health policy following publication earlier this year of its environmental health action plan.Critics may respond to the consultation document with suggestions for more far reaching targets-based, for example, on the "Health for A11" targets from the World Health Organisation, or those arising out of Agenda 21 from the earth summit in Rio De Janeiro.* Radon concentrations * Lead concentrations
Endoscopic Ultrasonography of Perianorectal Fistulas and Abscesses
Authors: T. L. Tio, G. E. Kallimanis
Journal: Endoscopy (1994)

In this article we describe the history, instrument, indications, and results of endoscopic ultrasonography (EUS) in the evaluation of perianorectal fistulas and abscesses. EUS has been reported to be helpful in the management of patients with Crohn's disease or colitis associated with fistulas and abscesses, due to its clear imaging of the leasion and valuable topographic anatomical information. Recent studies point out the relationship between EUS and electromyography. We believe EUS will become a standard procedure in the management of these complex disease processes.
Abstract 4426: Are there synergistic antiproliferative effects of paclitaxel and curcumin on osseus metastasis of renal cell carcinoma
Authors: Petra Reinecke, Matthias Biewer, Thomas Kalinski, Helmut Erich Gabbert
Journal: Cancer Research (2010)

Abstract Aim: Human renal cell carcinomas (RCCs) are highly resistant to conventional chemotherapy. Recently, paclitaxel has been shown to inhibit growth of RCCs in vitro. Therefore, we analyzed the chemotherapeutic potential of paclitaxel on our established cell line N109, derived from an osseous metastasis of a human RCC. In addition, we examined the role of the phytochemical curcumin on the growth inhibition which is known to act as a modulator of the Multidrug Resistance Phenotype. Methods: MTT assay, immunfluorescence microscopy and flow cytometry. Results: 1. Significant dose-dependent growth inhibition and paclitaxel-induced morphological alterations were observed in the cell line N109. 2. No significant dose-dependent growth inhibition was observed after exposure to curcumin alone. 3. A synergistic effect of growth inhibition was detected after treatment with both, paclitaxel and curcumin. 4. The cell line N109 shows a pronounced P-glycoprotein expression. 5. After exposure to paclitaxel or curcumin no remarkable modulation of the P-glycoprotein expression level was observed. Conclusion: This study demonstrates that paclitaxel can effectively inhibit the growth of an osseous metastasis of human renal cell carcinoma in vitro whereas a pronouced synergistic inhibition effect in combination with the phytochemical curcumin became evident. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4426.
Fc(epsilon)RI-(beta) polymorphisms unlikely to contribute substantially to genetic risk of allergic disease
Authors: I P Hall, A Wheatley, J Dewar, J Wilkinson, J Morrison
Journal: BMJ (1996)

FceRI-P polymorphisms unlikely to contribute substantially to genetic risk of allergic disease EDITOR,-M R Hill and colleagues report the association between a variant of the gene for the 1B chain of the high affinity receptor for IgE (FCeRI-O) with the Leu 181/Leu 183 polymorphism and atopy in an Australian population.'They suggest that polymorphism in FcsRI-is one factor that can be used to assign genetic risk of atopy.This group has previously suggested that Leu 181 may be associated with atopy in the British population.2As part ofa study examining the relation between 12 adrenoceptor polymorphisms and airway reactivity3 we recently screened a population of asthmatic patients for FcERI-3 polymorphisms.Polymerase chain reaction based on the amplification refractory mutation system failed to identify any subjects with either the Leu 181 or the Leu 181/ Leu 183 polymorphism.We therefore proceeded to direct sequencing of this region of FcsRI-to ensure that our ability to detect the Leu 181 polymorphism was not due to problems with the method.None of our 65 asthmatic subjects, however, had either the Leu 181 or the Leu 183 substitution on direct sequencing.Of these 65 subjects, 41 fulfilled Hill and colleagues' criteria for atopy, although all had a 20% fall in forced expiratory volume in one second after challenge with methacholine.These results suggest that, while FcsRI-P polymorphisms may contribute to the atopic phenotype in defined populations, they are unlikely to contribute substantially to the genetic risk of allergic disease in the population at large.
Chronic Thromboembolic Pulmonary Hypertension
Authors: J E Dixon, M A King
Journal: New England Journal of Medicine (2001)

Figure 1. A previously healthy 35-year-old man had increasing dyspnea on exertion over a period of several months. The results of a physical examination and transthoracic echocardiography suggested that he had pulmonary arterial hypertension and severe tricuspid regurgitation. A contrast-enhanced helical computed tomographic (CT) scan of the chest was obtained to look for evidence of pulmonary thromboembolism and to assess the lung parenchyma. Contiguous axial CT images through the main pulmonary arteries (Panel A) showed eccentric endothelialized thrombi in both pulmonary arteries (arrows). A CT image obtained at the level of the aortic arch (Panel B) showed a disparity in . . .
UK guidelines for management of acute pancreatitis: is it time to change?
Authors: K S Gurusamy
Journal: Gut (2005)

<h3>Objectives</h3> Ovarian cancer (OC) survivors experience many disease and treatment adverse effects. However, the impact of OC and its treatment on objective activity behaviors and physiological status have not been examined. The purpose of this study was to compare objectively measured activity behaviors and physiological characteristics of advanced-stage OC survivors to age-matched controls. <h3>Methods</h3> Twenty stage III–IV OC survivors and 20 controls completed assessments of activity behaviors (7-day accelerometry), physical function (400-meter walk as indicator of cardiorespiratory fitness, repeated chair rise, 6-meter walking tests), muscle strength (1-repetition maximum and handgrip), body composition (dual-energy x-ray absorptiometry), and musculoskeletal morphology (peripheral quantitative computed tomography). <h3>Results</h3> Compared with controls, OC survivors spent more time/day in prolonged sedentary bouts (<i>P</i> = 0.039, <i>r</i> = 0.32), had lower cardiorespiratory fitness (<i>P</i> = 0.041, <i>r</i> = 0.33) and upper body strength (<i>P</i> = 0.023, <i>r</i> = 0.37), had higher areal bone mineral content (<i>P</i> = 0.047, <i>r</i> = 0.33) and volumetric trabecular density (<i>P</i> = 0.048, <i>r</i> = 0.31), but were not different in other measures of body composition nor in muscle morphology (<i>P</i> &gt; 0.050). Only 20% (n = 4) of OC survivors accrued 150 minutes/week or greater moderate and vigorous physical activity (MVPA) time in 10-minute bouts or greater. Moderate and vigorous physical activity time/day in 10-minute bouts or greater was strongly associated with cardiorespiratory fitness (<i>P</i> = 0.001, ρ = −0.702) and lower extremity function (<i>P</i> = 0.019, ρ = −0.519) and moderately associated with muscle cross-sectional area (<i>P</i> = 0.035, ρ = 0.473). <h3>Conclusions</h3> Posttreatment OC survivors spent more time in prolonged sedentary bouts and had lower cardiorespiratory fitness and upper body strength compared with controls. Moderate and vigorous physical activity was associated with physical function and muscle cross-sectional area. Future studies should test the efficacy of exercise interventions to increase MVPA, reduce sedentary behavior, and increase cardiorespiratory fitness and muscle strength in OC survivors.
Vuillard's Room at the Château des Clayes
Authors: Thomas B. Cole
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The "Territorial Imperative" of Medicine
Authors: H. MARVIN POLLARD
Journal: Annals of Internal Medicine (1969)

Presidential Address1 August 1969The "Territorial Imperative" of MedicineH. MARVIN POLLARD, M.D., F.A.C.P.H. MARVIN POLLARD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-2-407 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptToday marks the opening of the Fiftieth Annual Scientific Meeting of the American College of Physicians since its founding in 1915. During this span of fifty scientific meetings there have been many changes in the field of internal medicine. These changes have involved approaches to medical education, the understanding of disease types, and the practice of medicine.At this time let me draw your attention to a book I hope many of you have read, written by Robert Ardrey and entitled,The Territorial Imperative. In it the author expresses the basic instinct of animals as being that of protection and...Bibliography1. AUDREY R: The Territorial Imperative, Dell Publishing Co., Inc., New York, 1966. Google Scholar2. : Medical licensure statistics for 1966. JAMA 200: 1055, 1967. CrossrefMedlineGoogle Scholar3. FEIN R: The Doctor Shortage. An Economic Diagnosis, The Brookings Institution, Washington, D. C., May 1967. Google Scholar4. FLEXNER A: Medical Education in the United States and Canada, Carnegie Foundation for the Advancement of Teaching, 1910. Google Scholar5. MILLIS JS: The Graduate Education of Physicians, The Report of the Citizens Commission on Graduate Medical Education, American Medical Association, Chicago, 1966. Google Scholar6. RUETHOMPSON CHWV: Personal communication, Chicago, Ill. Google Scholar7. SOUTTER L: Medical education and the university (1901 to 1968). New Eng. J. Med. 279: 294, 1968. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Presidential Address, given April 21, 1969 at the Fiftieth Annual Session of the American College of Physicians, Chicago, Ill.Requests for reprints should be addressed to H. Marvin Pollard, M.D., Department of Internal Medicine, University Hospital, University of Michigan Medical Center, Ann Arbor, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1969Volume 71, Issue 2Page: 407-413KeywordsInstinctMedical education Issue Published: 1 August 1969 PDF DownloadLoading ...
A phase I study of 153Sm-EDTMP with fixed high-dose melphalan as a peripheral blood stem cell conditioning regimen in patients with multiple myeloma
Authors: A Dispenzieri, G A Wiseman, M Q Lacy, M R Litzow, P M Anderson, D A Gastineau, A Tefferi, D J Inwards, I N M Micallef, S M Ansell, L Porrata, M A Elliott, J A Lust, P R Greipp, S V Rajkumar, R Fonseca, T E Witzig, C Erlichman, J A Sloan, M A Gertz
Journal: Leukemia (2004)
179. Transgenesis of B Lymphocytes by Bacterial DNA Is TLR9 Independent
Authors: Mara Gerloni, Matthew Wheeler, Xocthil Cortez-Gonzales, Ilenia Pellicciotta, Maurizio Zanetti
Journal: Molecular Therapy (2005)

Among the 11 TLRs identified, TLR9 is unique in its ability to recognize single-stranded DNA unmethylated at CpG motifs. TLR9 is an intracellular receptor so that its signaling requires that DNA is first internalized by the cell. Human and murine B lymphocytes are easily transfected by plasmid DNA. Here we show that transgenesis of B lymphocytes with plasmid DNA is CpG independent since it is not inhibited by cloroquine, it does not induce cell proliferation, and it occurs in TLR9-deficient murine B lymphocytes. Nevertheless, transfected B lymphocytes of both species up regulate B7.1 and CD40, events not inhibited by cloroquine treatment. Importantly, transfected B lymphocytes from TLR9-deficient mice can be used as antigen presenting cells to immunize mice and induce both CD4 and CD8 T cell responses. Collectively, these results suggest the existance of a yet unidentified pathway of activation of B lymphocytes and question the role of TLR9 in naked DNA transgenesis.
Diabetes Surgery: A New Approach to an Old Disease
Authors: Francesco Rubino, Tracy-Ann Moo, Daniel J. Rosen, Greg F. Dakin, Alfons Pomp
Journal: Diabetes Care (2009)

Since its earliest description several thousand years ago, diabetes has remained a chronic progressive disease (1). The disease now affects ∼200 million people worldwide, and diabetes-related death is expected to increase by >50% in the next 10 years (2). The situation is only getting worse. The prevalence of diabetes among the elderly has increased 63% in the 10 years 1994–2004 (3). This increasing prevalence is a testament to improvement in managing diabetes-related complications, as well as our global “modernization” and the accompanying metabolic derangements. Diabetes is now ranked as the sixth leading cause of death by disease in the U.S. (4). In many places, it ranks far higher. The economic burden in 2007 alone exceeded $174 billion (5).

Diet modification and oral hypoglycemic medications have proven inadequate, whereas insulin therapy only solves the problem temporarily. In the U.K. Prospective Diabetes Study, diabetic patients were treated with diet modification, metformin, sulfonylurea, or insulin. Consistent with the progressive nature of diabetes, monotherapy was abandoned in 75% of the patients studied in a follow-up of 9 years (6). Even with the newest pharmaco-therapies, patients continue to develop macro- and microvascular complications. Diabetes is associated with increased cardiac- and stroke-related deaths, kidney failure, blindness, and 60% of nontrauma lower-limb amputations (4). In cardiac surgery, diabetes as a preoperative risk factor confers greater morbidity than a previous myocardial infarction (7,8).

While these numbers show that diabetes will be the global health crisis of the next generation, its true pathophysiology has yet to be delineated. Alternative treatments targeting different models of this disease require careful and responsible examination. A large body of evidence now demonstrates surgery for type 2 diabetes can achieve up to complete disease remission, a goal almost unheard of in current diabetes care. Evidence collected over decades of bariatric …
Survival of the Legionnaires' Disease Bacterium in Water
Authors: PETER SKALIY
Journal: Annals of Internal Medicine (1979)

Data from this study indicate that the Legionnaires' disease bacterium can survive for a relatively long period of time in water. Four strains survived in distilled water for 69 to 139 d and for 364 to 369 d in tap water. Viable cells from two strains were recovered from tap water at 408 and 415 d. There were no surviving bacteria in cooling-tower water after 24 to 48 h. The rapid die-off was probably due to bactericidal agents added to the water to control growth.
CONCOMITANT ANAPHYLACTIC SENSITIZATION AND CONTACT UNRESPONSIVENESS FOLLOWING THE INFUSION OR FEEDING OF PICRYL CHLORIDE TO GUINEA PIGS
Authors: Jerome R. Pomeranz, Philip S. Norman
Journal: The Journal of Experimental Medicine (1966)

Guinea pigs receiving one large dose of picryl chloride by the intravenous or oral routes commonly develop circulating antibody demonstrable by passive cutaneous anaphylaxis or by active anaphylaxis. They often concommittantly become unresponsive to the induction of delayed contact hypersensitivity by intracutaneous injections. Erythrocytes obtained from guinea pigs after infusion or feeding of picryl chloride may be used to sensitize other animals when injected with adjuvant. It is concluded that guinea pigs may be anaphylactically sensitized to simple chemicals by the intravenous and oral routes if a sufficient dose is administered.