Plasma 3, 4-Dihydroxyphenylalanine (Dopa) and Catecholamines in Neuroblastoma or Pheochromocytoma
Authors: David S. Goldstein, Robin Stull, Graeme Eisenhofer, James C. Sisson, Alan Weder, Steven D. Averbuch, Harry R. Keiser
Journal: Annals of Internal Medicine (1986)

Brief Reports1 December 1986Plasma 3, 4-Dihydroxyphenylalanine (Dopa) and Catecholamines in Neuroblastoma or PheochromocytomaDAVID S. GOLDSTEIN, M.D., Ph.D., ROBIN STULL, B.S., GRAEME EISENHOFER, Ph.D., JAMES C. SISSON, M.D., ALAN WEDER, M.D., STEVEN D. AVERBUCH, M.D., HARRY R. KEISER, M.D.DAVID S. GOLDSTEIN, M.D., Ph.D., ROBIN STULL, B.S., GRAEME EISENHOFER, Ph.D., JAMES C. SISSON, M.D., ALAN WEDER, M.D., STEVEN D. AVERBUCH, M.D., HARRY R. KEISER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-6-887 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeuroblastomas and benign and malignant pheochromocytomas are tumors of neural-crest origin that have different clinical characteristics: neuroblastomas are aggressive tumors that occur in children and have no association with hypertension, and pheochromocytomas are slow-growing tumors that occur in both adults and children and have an association with hypertension. Malignant and benign pheochromocytomas cannot be distinguished histologically; malignancies are defined by metastasis.Consistent with their ontogeny, these tumors contain catecholamine precursors, catecholamines, and catecholamine metabolites. Urinary rates of excretion of these substances are key factors in tumor diagnosis. In human urine, the predominant free (unconjugated) catecholamine is dopamine, which probably is...References1. VON STUDNITZKASERSJOERDSMA WHA. Spectrum of catecholamine biochemistry in patients with neuroblastoma. N Engl J Med. 1963;269:232-5. CrossrefMedlineGoogle Scholar2. VOORHESS M. The catecholamines in tumor and urine from patients with neuroblastoma, ganglioneuroblastoma and pheochromocytoma. J Pediatr Surg. 1968;3:147-8. CrossrefMedlineGoogle Scholar3. HELSONJOHNSONSMITH LGR. DOPA metabolism in neuroblastoma. Med Pediatr Oncol. 1980;8:317-22. CrossrefMedlineGoogle Scholar4. BRAVOGIFFORD ER. Current concepts: pheochromocytoma: diagnosis, localization and management. N Engl J Med. 1984;311:1298-303. CrossrefMedlineGoogle Scholar5. GOLDSTEINSTULLZIMLICHMANLEVINSONSMITHREISER DRRPHH. Simultaneous measurement of DOPA, DOPAC, and catecholamines in plasma by liquid chromatography with electrochemical detection [Letter]. Clin Chem. 1984;30:815-6. 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Author, Article, and Disclosure InformationAffiliations: National Institutes of Health Bethesda, Maryland University of Michigan School of Medicine Ann Arbor, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBiochemical testing for neuroblastoma using plasma free 3‐O‐methyldopa, 3‐methoxytyramine, and normetanephrineAge-specific pediatric reference intervals for plasma free normetanephrine, metanephrine, 3-methoxytyramine and 3-O-methyldopa: Particular importance for early infancyMicroplate based optical biosensor for l-Dopa using tyrosinase from Amorphophallus campanulatusCatecholamines and SerotoninCatecholamines 101PheochromocytomaPheochromocytoma and ParagangliomaBiochemical diagnosis of pheochromocytoma and paragangliomaMalignant Pheochromocytoma: State of the Field with Future ProjectionsNormotensive Pheochromocytoma: Institutional ExperiencePrevalence of hepatitis B and C virus infection in haematological malignancies and liver injury following chemotherapyHypotension in a Woman with a Metastatic Dopamine-Secreting Carotid Body TumorPhaeochromocytoma: a case studySources and Significance of Plasma Levels of Catechols and Their Metabolites in HumansThe Adrenal MedullaMalignant and Benign PheochromocytomaMalignant PheochromocytomaSecondary hypertension: Evaluation and treatment3,4-Dihydroxyphenylalanine (DOPA) Metabolism in Screening-Detected and Non-Screening-Detected NeuroblastomaRemarkably Suppressed Manganese Superoxide Dismutase Activity in Malignant PheochromocytomaRemarkably Suppressed Manganese Superoxide Dismutase Activity in Malignant PheochromocytomaHigh-performance liquid chromatographic analysis with electrochemical detection of biogenic amines using microbore columnsMalignant Phaeochromocytoma with High Circulating DOPA, and Clonidine-Suppressible Noradrenaline3,4-Dihydroxyphenylalanine (DOPA) metabolism and retinoic acid induced differentiation in human neuroblastomaPhaeochromocytoma and Related TumoursHigh incidence of malignant pheochromocytoma in a surgical unit. 26 cases out of 100 patients operated from 1971 to 1991The role of epinephrine, norepinephrine, and dopamine in blood pressure disturbances in patients with pheochromocytomaMethod for measuring endogenous 3-O-methyldopa in urine and plasmaRegional extraction of circulating norepinephrine, DOPA, and dihydroxyphenylglycol in humansGlucagon and clonidine testing in the diagnosis of pheochromocytoma.Diagnostic problems in pheochromocytomaSkin color, aging, and plasma l-dopa levelsMalignant Pheochromocytoma: Effective Treatment with a Combination of Cyclophosphamide, Vincristine, and DacarbazineSteven D. Averbuch, MD, Caryn S. Steakley, RN, Robert C. Young, MD, Edward P. Gelmann, MD, David S. Goldstein, MD, PhD, Robin Stull, BS, Harry R. Keiser, MDCatecholamines and their metabolitesA new approach to biochemical evaluation of brain dopamine metabolism 1 December 1986Volume 105, Issue 6Page: 887-888KeywordsCatecholaminesChildrenDopamineExcretionHypertensionMalignant tumorsMetabolitesNeuroblastomaPheochromocytomaUrine Issue Published: 1 December 1986 PDF DownloadLoading ...