tbuckley/cabot-search huggingface dataset:
THE MORTALITY RATE FOLLOWING OPERATIONS ON THE THYROID GLAND
Authors: CHARLES H. MAYO
Journal: JAMA (1923)

The diseases of the thyroid, such as exophthalmic goiter, and adenomatous goiter with hyperthyroidism have lost their former place among serious and fatal surgical ailments. The present great reduction in surgical mortality demonstrates the benefit of medical and surgical team work in the diagnosis and classification of thyroid diseases. Medical treatment is curative or beneficial in certain forms of goiter. In types of the disease formerly so fatal if untreated, and also having a high mortality surgically, improvement may be obtained by proper care. The actual dangers from avoidable surgical accidents and complications are now better recognized. This is all the result of the greater attention, both medical and surgical, paid to diseases of the thyroid. Any discussion or argument, any fad, medical or surgical, which will lead to more care, will lower mortality, as a by-product, so to speak, and therefore is justified by the results. In order properly
Renal Artery Embolism
Authors: RICHARD K. LESSMAN
Journal: Annals of Internal Medicine (1978)

Spontaneous renal artery embolism is not rare, but a correct diagnosis and appropriate treatment are often delayed. Clinical features and follow-up of 17 cases are reported. Cardiac disease or arrhythmias pre-existed in 16 patients. Initial symptoms included flank pain (seven cases), abdominal or chest pain alone (seven), and nausea and vomiting (eight). Fever (≥ 37.5 °C) occurred in 10 cases and flank tenderness in only eight. Laboratory findings included leukocytosis, proteinuria, hematuria, and elevated levels of lactic dehydrogenase, serum glutamic-oxalacetic transaminase, serum glutamic-pyruvic transaminase, and alkaline phosphatase. Serum creatinine level exceeded 1.3 mg/dl in 88% and 4.0 mg/dl in 65%; four patients required dialysis. The diagnosis, made by scintiscan, arteriography, or both was often delayed. Renal embolization was bilateral in seven patients and unilateral in 10, with serum creatinine level above 4.0 mg/dl in five of the latter. Emboli to other organs caused early death; cardiovascular disease led to later death. With anticoagulants, renal function returned in patients surviving more than 1 month, even those with bilateral emboli. Thus, renal embolism is recognizable if the disease is considered, and a favorable outcome is common with long-term anticoagulants.
Preoperative drainage using a transanal tube enables elective laparoscopic colectomy for obstructive distal colorectal cancer
Authors: T. Yamada, T. Shimura, E. Sakamoto, Y. Kurumiya, S. Komatsu, H. Iwasaki, S. Nomura, H. Kanie, H. Hasegawa, E. Orito, T. Joh
Journal: Endoscopy (2013)

<b>Background and study aims: </b>Acute colorectal obstruction (ACO) often accompanies colorectal cancer (CRC) and requires urgent treatment, but achieving elective laparoscopy-assisted colectomy (LAC) is difficult in this setting. The aim of the current study was to assess the clinical outcomes of a transanal tube (Dennis colorectal tube [DCT]) for CRC with ACO, focusing in particular on the impact of the DCT on subsequent elective LAC. <b>Patients and methods: </b>Among 1142 patients who underwent surgery for CRC between January 2007 and December 2011, 92 patients with ACO were identified retrospectively. Of these 92 patients, the DCT procedure was performed in 66 patients who fulfilled the indications for DCT, and these patients were included in the study. <b>Results: </b>All 66 patients presented with complete obstruction. Technical and clinical success rates for DCT were 93.9 % and 86.4 %, respectively. Perforation after DCT occurred in 4.5 % and the mortality rate was 1.5 %. The rate of LAC was 48.5 %, and the rate of primary stoma was 13.6 %. For curative stage II/III CRC with ACO, DCT resulted in a primary stoma rate of 13.6 %, a one-stage surgery rate of 90.9 %, a LAC rate of 50.0 %, and a 3-year survival rate of 73.1 %. For stage II/III CRC cases with clinical success by DCT, the one-stage surgery rate was 97.4 % and the LAC rate was 56.4 %. <b>Conclusions: </b>DCT achieved a high rate of clinical success and enabled safe one-stage surgery and LAC for CRC with ACO. DCT followed by LAC is proposed as a promising non-invasive strategy for CRC with ACO.
Evaluation of the Long-Term Efficacy and Safety of Infliximab Treatment for Uveitis in Behçet's Disease
Authors: Masaru Takeuchi, Takeshi Kezuka, Sunao Sugita, Hiroshi Keino, Kenichi Namba, Toshikatsu Kaburaki, Kazuichi Maruyama, Kei Nakai, Kuniaki Hijioka, Etsuko Shibuya, Keiko Komae, Junko Hori, Nobuyuki Ohguro, Koh-hei Sonoda, Nobuhisa Mizuki, Annabelle A. Okada, Tatsuro Ishibashi, Hiroshi Goto, Manabu Mochizuki
Journal: Ophthalmology (2014)
Abstract A77: Transmembrane 4 L six family member 5 (TM4SF5) regulates FAK/c-Src signaling activity for cell migration and invasion
Authors: Oisun Jung, Yoon-Ju Choi, Jung Weon Lee
Journal: Cancer Research (2013)

Abstract Transmembrane 4 L six family member 5 (TM4SF5) is a transmembrane glycoprotein of the transmembrane 4 L six family and highly expressed in many types of cancers. In addition to diverse tumorigenic functions, TM4SF5 also plays roles in migration and invasion, leading to lung metastasis of TM4SF-positive cells injected into tail veins. To understand the TM4SF5-mediated metastatic roles, we mechanistically explored TM4SF5-mediated signaling pathways for migration and invasion. Using endogenously or exogenously TM4SF5-null or -expressing hepatocytes in vitro and mouse animals in vivo, we revealed how TM4SF5 mediated the metastatic processes along the leading edges of migratory/invasive cells. The intracellular loop of TM4SF5 directly and adhesion-dependently bound FAK with causing a structural alteration possibly to release the inhibitory intramolecular interaction, which activated FAK at the leading edges of cells to promote migration/invasion and in vivo metastasis. Impaired interactions between TM4SF5 and FAK attenuated phospho-FAK, signaling link to actin organization machinery, and metastatic potentials. Meanwhile, the cytosolic C-terminus of TM4SF5 bound c-Src that led to invasive protrusion formation. Wildtype TM4SF5 expression enhanced invasive protrusion formation in a c-Src-dependent manner, compared with TM4SF5-null control hepatocytes, but tailless TM4SF5ΔC cells were more efficient than were wildtype TM4SF5 cells, suggesting a negatively regulatory role by its C-terminus. c-Src activity of TM4SF5 WT- or TM4SF5ΔC-expressing cells EGF-independently correlated with enhanced phospho-Tyr845 in EGFR for the invasive protrusions. Altogether, this study suggests that TM4SF5 is involved in signaling for migration and invasion and is a promising target for the treatment of TM4SF5-positively metastatic cancer. Citation Format: Oisun Jung, Yoon-Ju Choi, Jung Weon Lee. Transmembrane 4 L six family member 5 (TM4SF5) regulates FAK/c-Src signaling activity for cell migration and invasion. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A77.
TCT-159 Effects of PRT-201, a Recombinant Human Type I Pancreatic Elastase, Treatment on the Elastin Content and Compliance of Atherosclerotic Tibial Arteries Following Ex Vivo Angioplasty
Authors: Steven Burke, Emma Moss, Karen Macdonald, Marco Wong, Daniel Gottlieb, Kimberly Bland, F. Nicholas Franano
Journal: Journal of the American College of Cardiology (2012)
How to spot a "spamnal"
Authors: Mary E Black
Journal: BMJ (2011)

I receive a constant stream of emails announcing dodgy journals or “spamnals” from bogus individuals riding the open access publication wave. Once in possession of your email address, these parasites exhibit the same characteristics as ground elder in your garden—pesky, difficult to eradicate, and recurrent. Thank heavens for my email spam filter.

Last week I dealt with a weeping doctoral student from Poland who had been conned out of $200 for the publication of an article in a spamnal, a citation that I advised would …
Medicolegal Investigational Systems: New Demands in the 1970's
Authors: William J. Curran
Journal: New England Journal of Medicine (1971)

IN the United States today, medicolegal investigation of deaths is poorly handled in well over 60 per cent of American legal jurisdictions. Part of the shame, the scandal, of this condition lies in the fact that it has existed for so long. It has improved but little during this entire century. Yet long standing problems tend not to be remedied for that very reason: they have been around for so long that officialdom and the man in the street alike see no pressing need to cope with them.It there was a fault in the recently released reports on the . . .
Combination of mesenchymal stem cell transplantation and angiogenic gene transfer for myocardial regeneration and therapeutic angiogenesis
Authors: Tae-Jin Youn, Hainan Piao, Young-Hwa Kim, So-Young Choi, Jin-Sook Kwon, Bo-Ra Son, Dong-Woon Kim, Seung-Taik Kim, Myeong-Chan Cho
Journal: Journal of the American College of Cardiology (2003)
Letter: HLA antigens in haemochromatosis.
Authors: W G Shewan, S A Mouat, T M Allan
Journal: BMJ (1976)

placental carcinogenic effects of stilboestrol.We are at present engaged in an investigation, using similar methodology, of possible aetio- logical factors in carcinoma of the endometrium in young women.The above are, of course, only a small sample of the many studies which could have been cited.We hope, however, that they will remind your readers that cancer registration is worth while even if it is feasible to collect only the simplest of information.
Aristotle's Anomaly
Authors: Jack R. Harnes
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Intrigued by the description of Aristotle's anomaly inThe Journal(1982;248:89), I set out to confirm his observation. My initial assumption was that the index and middle fingers should be crossed. I did this both ways and inserted the pencil between the shafts of the fingers and between the tips of the fingers (except that I could not get a pencil between the tip of my index and middle finger when the index finger was on top). I did not feel two pencils. I then crossed my thumb and index finger in both directions and inserted a pencil in various positions and again felt only one pencil. The following three possibilities come to mind: 1. Aristotle's observation may not have been accurate. In fact, one might question whether a pencil was available to him, since the Encyclopaedia Britanica reports they were first invented in 1565. 2. I
Long-Term Outcomes After Medical and Invasive Treatment in Patients With Hypertrophic Cardiomyopathy
Authors: Pieter A. Vriesendorp, Max Liebregts, Robbert C. Steggerda, Arend F.L. Schinkel, Rik Willems, Folkert J. ten Cate, Johan van Cleemput, Jurriën M. ten Berg, Michelle Michels
Journal: JACC Heart Failure (2014)
Uric Acid Nephropathy
Authors: Michael C. Perry
Journal: JAMA (1976)

GOUTY arthropathy, urate lithiasis, and acute uric acid nephropathy may all complicate the course in a patient who has a malignant disease. All three problems originate from an increased uric acid turnover that occurs in this type of disease. Hyperuricemia may range in importance from an incidental chemical abnormality to a life-threatening complication. Therefore, when it is encountered in this situation, it should not be ignored. Although hyper-uricemia is seen most commonly in association with acute and chronic leukemias, lymphomas, myeloma, and the myeloproliferative syndromes, it is also noted with increasing frequency in patients with nonhematologic malignancy. Often present before treatment, its prevalence and severity increase during successful radiotherapy or chemotherapy of the malignant disease. Increased production of uric acid is the by-product of unrestrained tumor-cell growth. As effective treatment destroys malignant cells, serum uric acid levels rise because of a limited renal capacity for handling urate. Elevated serum uric
Effect of serotesting with counselling on condom use and seroconversion among HIV discordant couples in Africa.
Authors: S. Allen, J. Tice, P. Van de Perre, A. Serufilira, E. Hudes, F. Nsengumuremyi, J. Bogaerts, C. Lindan, S. Hulley
Journal: BMJ (1992)

OBJECTIVE--To determine whether HIV testing and counselling increased condom use and decreased heterosexual transmission of HIV in discordant couples. DESIGN--Prospective study. SETTING--Kigali, the capital of Rwanda. SUBJECTS--Cohabiting couples with discordant HIV serology results. MAIN OUTCOME MEASURES--Condom use in the couple and HIV seroconversion in the negative partners. RESULTS--60 HIV discordant couples were identified, of whom 53 were followed for an average of 2.2 years. The proportion of discordant couples using condoms increased from 4% to 57% after one year of follow up. During follow up two of the 23 HIV negative men and six of the 30 HIV negative women seroconverted (seroconversion rates of 4 and 9 per 100 person years). The rate among women was less than half that estimated for similar women in discordant couples whose partners had not been serotested. Condom use was less common among those who seroconverted (100% v 5%, p = 0.01 in men; 67% v 25%, p = 0.14 in women). CONCLUSIONS--Roughly one in seven cohabiting couples in Kigali have discordant HIV serological results. Confidential HIV serotesting with counselling caused a large increase in condom use and was associated with a lower rate of new HIV infections. HIV testing is a promising intervention for preventing the spread of HIV in African cities.
Variation in the deposition of the antibodies at different anatomical sites in linear IgA disease of adults and chronic bullous disease of childhood
Authors: P.M. COLLIER, F. WOJNAROWSKA, P.R. MILLARD
Journal: British Journal of Dermatology (1992)

The diagnosis of linear IgA disease of adults (LAD) and chronic bullous disease of childhood (CBDC) relies upon finding a linear band of IgA at the basement membrane zone on direct immunofluorescence. This study examines the regional variation in antigen expression in the skin of affected individuals. Direct immunofluorescence was performed on biopsies from four different sites in 17 patients with these diseases. In two patients a biopsy from the volar surface of the forearm was negative, but other sites were positive; in the remaining patients there was no variation in antibody expression with site. It is therefore recommended that, if a single diagnostic biopsy is to be taken, the volar surface of the forearm is avoided.
Primary Splenic Lymphoma Detected by F-18 FDG PET
Authors: Fumika Takata, Hayato Kaida, Masatoshi Ishibashi, Seiji Kurata, Jun Uozumi, Masafumi Uchida, Takashi Okamura, Shinji Uchida, Kouichi Oshima, Shgeki Ban, Shigenobu Meno, Naofumi Hayabuchi
Journal: Clinical Nuclear Medicine (2008)

F-18 FDG uptake of splenic involvement by malignant lymphoma has frequently been seen, but reports of F-18 FDG PET related to primary splenic lymphoma (PSL) are very rare. We describe herein a case of PSL detected by F-18 FDG PET. A 66-year-old woman was referred for further examination due to indications of a solitary splenic tumor. F-18 FDG PET revealed the abnormal focal uptake of the spleen. Laparoscopic splenorectomy was performed to acquire the histopathological findings. The histopathological findings of splenic tumor were diffuse large B-cell lymphoma.
Temporal evolution of pleural fibrosis induced by intrapleural minocycline injection.
Authors: C S Sassoon, R W Light, F S Vargas, S E Gruer, N S Wang
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Minocycline is as effective as tetracycline in inducing pleural fibrosis, but the long-term pleural changes induced by minocycline are unknown. The objective of this study was to evaluate in rabbits the evolution of the pleural changes induced by the intrapleural instillation of minocycline. Under light anesthesia, minocycline at 10 mg/kg in a total volume of 2 ml of bacteriostatic saline solution was injected into the right pleural space of 25 male rabbits. The animals were sacrificed in groups of five at 15 d and 1, 2, 4, and 6 mo. Macroscopic and microscopic examinations of the pleura were performed for evidence of pleural fibrosis and inflammation. Similarly, the underlying lung was also examined for microscopic alveolar fibrosis and inflammation. During the 6-mo observation period there was no significant change in the degree of pleural fibrosis. In contrast, microscopic pleural inflammation, alveolar fibrosis, and alveolar inflammation all decreased significantly over the observation period. In conclusion, intrapleural minocycline injection results in persistent pleural fibrosis at 6 mo. It remains to be determined whether the pleural fibrosis will persist beyond this period.
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
Authors: Paul M. Ridker, Nader Rifai, Meir J. Stampfer, Charles H. Hennekens
Journal: Circulation (2000)

Background —Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse. Methods and Results —In a prospective study involving 14 916 apparently healthy men, we measured baseline plasma concentration of IL-6 in 202 participants who subsequently developed myocardial infarction (MI) and in 202 study participants matched for age and smoking status who did not report vascular disease during a 6-year follow-up. Median concentrations of IL-6 at baseline were higher among men who subsequently had an MI than among those who did not (1.81 versus 1.46 pg/mL; P =0.002). The risk of future MI increased with increasing quartiles of baseline IL-6 concentration ( P for trend &lt;0.001) such that men in the highest quartile at entry had a relative risk 2.3 times higher than those in the lowest quartile (95% CI 1.3 to 4.3, P =0.005); for each quartile increase in IL-6, there was a 38% increase in risk ( P =0.001).This relationship remained significant after adjustment for other cardiovascular risk factors, was stable over long periods of follow-up, and was present in all low-risk subgroups, including nonsmokers. Although the strongest correlate of IL-6 in these data was C-reactive protein ( r =0.43, P &lt;0.001), the relationship of IL-6 with subsequent risk remained after control for this factor ( P &lt;0.001). Conclusions —In apparently healthy men, elevated levels of IL-6 are associated with increased risk of future MI. These data thus support a role for cytokine-mediated inflammation in the early stages of atherogenesis.
The Appropriateness of Tympanostomy Tubes for Children
Authors: Erdem I. Cantekin
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Dr Kleinman and colleagues<sup>1</sup>report that 41% of tympanostomy tube insertions are appropriate. This astonishing conclusion translates in 1994 into some 600 000 unnecessary pediatric surgical procedures in the United States at a cost of $1.2 billion. Kleinman et al, without any scientific evidence, recommend that surgery not be performed "until a perfusion persists through a course of antibiotics and at least 90 days of watchful waiting" and that antibiotic prophylaxis be used for recurrent otitis media. They do not cite their own abstract,<sup>2</sup>which reported that of 3970 children proposed for tympanostomy tube surgery, each child was treated unsuccessfully with an average 4.3 courses of antibiotics. The data collected by Kleinman et al indicate the ineffectiveness of ubiquitous antibiotic treatment. The argument of Kleinman et al, reduced to a nutshell, is that the other 59% of children should also be aggressively and unsuccessfully treated
Dementia: A Winter Veil
Authors: Suzanne Rogier Marshall
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Cells: Underwater‐Transparent Nanodendritic Coatings for Directly Monitoring Cancer Cells (Adv. Healthcare Mater. 3/2014)
Authors: Gao Yang, Hongliang Liu, Xueli Liu, Pengchao Zhang, Chao Huang, Tailin Xu, Lei Jiang, Shutao Wang
Journal: Advanced Healthcare Materials (2014)

A nanodendritic silica coating is shown to be highly transparent under water. On page 332, Shutao Wang and co-workers show such unique coating can not only efficiently capture cancer cells from whole blood samples, but also directly monitor the captured cancer cells. This nanostructured coating represents a multifunctional platform for biomedicine applications.
Aspects of male mortality.
Authors: M Ryan
Journal: BMJ (1982)

condition improved with the appropriate treatment, and she recovered completely in a month.It is thus very important to exclude the complications mentioned above in a patient with subarachnoid haemorrhage before considering whether the patient is unfit for surgery.It is also clear that a non-alcoholic patient can develop profound nutritional deficiency, and it is essential to give a balanced diet with vitamin supplements to patients who are critically ill for long periods.
Johnson's Early Sign of Pregnancy Observed in the Fundus.
Authors: L. M. Giffin
Journal: JAMA (1904)

Boulder, Colo., April 14, 1904. <h3>To the Editor:</h3> —Dr. H. L. E. Johnson mentions inThe Journal, Feb. 20, 1904, the alternate changing of color, from violet to pink, shown in the vaginal cervix of the pregnant uterus as early as four weeks. An opportunity to observe this sign in the fundus uteri was given us a few weeks since. March 15, 1904, a woman, three and one-half months pregnant, presented herself at the University Hospital (Medical Department, University of Colorado), for relief from intestinal obstruction. Her condition was so grave that it was thought advisable to make an exploratory incision. The incision revealed a right parovarian cyst with twisted pedicle. During the removal of the cyst, the fundus uteri was in plain view and the delicate successions from a pale to a bright pink were truly beautiful. The alternations occurred exactly every sixty seconds. They were not a gradual