tbuckley/cabot-search huggingface dataset:
Manganese Exposure from Drinking Water and Children’s Classroom Behavior in Bangladesh
Authors: Khalid Khan, Pam Factor-Litvak, Gail A. Wasserman, Xinhua Liu, Ershad Ahmed, Faruque Parvez, Vesna Slavkovich, Diane Levy, Jacob Mey, Alexander van Geen, Joseph H. Graziano
Journal: Environmental Health Perspectives (2011)

Background: Evidence of neurological, cognitive, and neuropsychological effects of manganese (Mn) exposure from drinking water (WMn) in children has generated widespread public health concern. At elevated exposures, Mn has been associated with increased levels of externalizing behaviors, including irritability, aggression, and impulsivity. Little is known about potential effects at lower exposures, especially in children. Moreover, little is known regarding potential interactions between exposure to Mn and other metals, especially arsenic (As).Objectives: We conducted a cross-sectional study of 201 children to investigate associations of Mn and As in tube well water with classroom behavior among elementary school children, 8–11 years of age, in Araihazar, Bangladesh.Methods: Data on exposures and behavioral outcomes were collected from the participants at the baseline of an ongoing longitudinal study of child intelligence. Study children were rated by their school teachers on externalizing and internalizing items of classroom behavior using the standardized Child Behavior Checklist-Teacher's Report Form (CBCL-TRF).Results: Log-transformed WMn was positively and significantly associated with TRF internalizing [estimated β = 0.82; 95% confidence interval (CI), 0.08–1.56; p = 0.03], TRF externalizing (estimated β = 2.59; 95% CI, 0.81–4.37; p =0.004), and TRF total scores (estimated β = 3.35; 95% CI, 0.86–5.83; p = 0.008) in models that adjusted for log-transformed water arsenic (WAs) and sociodemographic covariates. We also observed a positive monotonic dose–response relationship between WMn and TRF externalizing and TRF total scores among the participants of the study. We did not find any significant associations between WAs and various scales of TRF scores.Conclusion: These observations reinforce the growing concern regarding the neurotoxicologic effects of WMn in children.
Quantitative coronary angiography in the estimation of the functional significance of coronary stenosis: Correlations with dobutamine-atropine stress test
Authors: Jose Baptista, Mariarosaria Arnese, Jos R.T.C. Roelandt, Paolo Fioretti, David Keane, Javier Escaned, Eric Boersma, Carlo di Mario, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (1994)
Reducing Antibody Levels in Patients Undergoing Transplantation
Authors: Ron Shapiro
Journal: New England Journal of Medicine (2008)

The advent of solid-organ transplantation for the treatment of patients with end-stage organ failure has been one of the most exciting medical advances in the late 20th and early 21st centuries. Thousands of lives have been saved or improved by transplantation, allowing terminally ill patients to rejoin society, work productively, and have a meaningful life.1,2 Unfortunately, transplantation has been an imperfect and expensive therapy. The financial burden of transplantation has limited its widespread application in the developed world; furthermore, therapeutic failure occurs all too often, owing to side effects or inadequacy of immunosuppression. Fortunately, in recent years, the potency . . .
Elevated adrenocorticotropic hormone and cortisol levels in a patient with medullary carcinoma of the thyroid containing ectopic immunoreactive corticotropin-releasing hormone and bombesin
Authors: V. Popovic, Z. Milosevic, I. Doniach, D. Micic, M. Nesovic, M. Odavic, M. Petakov, A. Kendereski, M. Sumarac, D. Manojlovic, J. Micic, G. M. Besser
Journal: Endocrine Pathology (1991)
Depression of cellular immunity as an index of malnutrition in surgical patients
Authors: D M A Francis, B K Shenton
Journal: BMJ (1981)

While COVID-19 brings unprecedented challenges to the US healthcare system, understanding narratives of historical disasters illuminates ethical complexities shared with COVID-19. In 2005, Hurricane Katrina revealed a lack of disaster preparation and protocol, not dissimilar to the challenges faced by COVID-19 healthcare workers. A case study of Memorial Hospital during Hurricane Katrina reported by journalist-MD Sheri Fink reveals unique ethical challenges at the forefront of health crises. These challenges include disproportionate suffering in structurally vulnerable populations, as seen in COVID-19 where marginalised groups across the USA experience higher rates of disease and COVID-19-related death. Journalistic accounts of Katrina and COVID-19 offer unique perspectives on the ethical challenges present within medicine and society, and analysis of such stories reveals narrative trajectories anticipated in the aftermath of COVID-19. Through lenses of social suffering and structural violence, these narratives reinforce the need for systemic change, including legal action, ethical preparedness and physician protection to ensure high-quality care during times of crises. Narrative Medicine—as a practice of interrogating stories in medicine and re-centering the patient—offers a means to contextualise individual accounts of suffering during health crises in larger social matrices.
Specialization in Health Care
Authors: George F. Sheldon
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renewing Board Certification
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (2005)

Interview with Dr. F. Daniel Duffy on internal medicine's new recertification requirements. (07:08)Download Many persons argue that certification of a specialist indicates that he is up-to-date and competent at the time of examination but this does not prove that he continues indefinitely thereafter to be competent and aware of all important new knowledge in his field. This is obviously true and, as the certifying Boards become established and as they complete the examination of the large group of physicians already practicing the specialties, they may find it desirable to issue certificates that are valid for a stated period only.— The Commission on Graduate Medicine, 1940Like gross anatomy class and the first . . .
LEFT VENTRICULAR THICKNESS AND ELECTROCARDIOGRAPHIC VOLTAGE CRITERIA IN A MULTIETHNIC POPULATION OF YOUNG ATHLETES: RESULTS FROM THE TEXAS ADOLESCENT ATHLETE HEART SCREENING REGISTRY (TAAHSR)
Authors: Silvana M. Lawrence, Harold W. Kohl, Jennifer Y. Hutchings, Kim A. Frost, Geoffrey P. Whitfield, James M. Guerrero, Eva M. Garcia, George P. Rodgers, Arnold A. Fenrich
Journal: Journal of the American College of Cardiology (2013)
Update of technologies for examining the stratum corneum at the molecular level
Authors: L. Norlén
Journal: British Journal of Dermatology (2014)

Journal Article Update of technologies for examining the stratum corneum at the molecular level Get access L. Norlén L. Norlén Department of Cell and Molecular Biology Karolinska Institutet, and Dermatology Clinic Karolinska University Hospital Stockholm Sweden Correspondence Lars Norlén. E‐mail: lars.norlen@ki.se Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue s3, 1 September 2014, Pages 13–18, https://doi.org/10.1111/bjd.13280 Published: 01 September 2014
Investing in alcohol is no longer responsible
Authors: Joseph M Barry, Tom O'Dowd
Journal: BMJ (2007)

“Doctors are stalwart drinkers,” says Richards, calling on doctors to do more to tackle alcohol abuse.1 Doctors are also stalwart investors and must begin to use their financial clout as shareholders to remove alcohol from their portfolios.

Last autumn, the multinational drinks industry used its political, business, and financial lobbying muscle to subvert the European Commission's attempts …
715 THREE-YEARS OF CONTINUOUS ENTECAVIR TREATMENT IN CHINESE PATIENTS WHO HAD PREVIOUSLY FAILED LAMIVUDINE: RESULTS FROM STUDIES ETV-056 AND -050
Authors: G.B. Yao, D.Z. Xu, H. Ren, X.Q. Zhou, J.D. Jia, Y.M. Wang, C.W. Chen, J. Liu, D. Xu, C. Llamoso
Journal: Journal of Hepatology (2008)
Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles
Authors: Hao Ren, Min Han, Jing Zhou, Ze-Feng Zheng, Ping Lu, Jun-Juan Wang, Jia-Qiu Wang, Qi-Jiang Mao, Jian-Qing Gao, Hong Wei Ouyang
Journal: Biomaterials (2014)
100 NOTCH1 SIGNALING IN LIVER SINUSOIDAL ENDOTHELIAL CELLS IS ESSENTIAL FOR HOMEOSTASIS OF THE HEPATIC MICROCIRCULATION
Authors: S. Rothweiler, M.T. Dill, V. Djonov, R. Hlushchuk, L. Tornillo, L. Terracciano, M. Heim, D. Semela
Journal: Journal of Hepatology (2010)
Melanoma-associated retinopathy: high frequency of subclinical findings in patients with melanoma
Authors: C. Pfohler, A. Haus, A. Palmowski, S. Ugurel, K.W. Ruprecht, C.E. Thirkill, W. Tilgen, U. Reinhold
Journal: British Journal of Dermatology (2003)

Summary Background Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome with symptoms of night blindness, light sensations, visual loss, defect in visual fields, and reduced b-waves in the electroretinogram. Patients with MAR often suffer from a sudden onset of ocular symptoms that are believed to result from antibody production against melanoma-associated antigens that cross-react with corresponding epitopes on retinal depolarizing bipolar cells. Objectives To correlate the frequency of subclinical symptoms suggestive of MAR in melanoma patients to different stages of disease, patient age, type and thickness of the primary tumour, form of therapy, S-100 level and tumour burden. Methods We analysed 28 patients with melanoma in stages I–IV (according to the American Joint Committee on Cancer tumour classification) for the presence of subclinical MAR symptoms using scotopic electroretinography, static and kinetic perimetry and nyctometry. Results Seven patients had clinical signs and symptoms consistent with MAR, 18 had some indications, while the remaining three had none. We found no correlation between clinical symptoms and stage of disease, tumour burden or S-100 level, but findings suggestive of MAR were observed more frequently in advanced stages of disease. Conclusions Subclinical retinal involvement characteristic of MAR appears to be more common than previously suspected in patients with cutaneous malignant melanoma. Our findings in this small cohort seem to indicate that the percentage of patients with symptoms suggestive of MAR is higher in advanced stages of disease. Further clinical studies are required to evaluate if the presence of subclinical symptoms suggestive of MAR is correlated with a worse prognosis and a shortened progression-free and overall survival.
St Mark's guideline
Authors: J. O. Drife
Journal: BMJ (1999)

Dear Chaplain, It has been brought to the attention of the trust guidelines committee that you are distributing a booklet entitled The Gospel According to St Mark . The committee has obtained a copy and has requested comments from the relevant departments. Several concerns have been raised.

1.  In the title, “gospel” should be changed to “guideline.” “Gospel” implies inflexibility. With a guideline, however, adherence is closely monitored and persistent deviation …
Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells
Authors: Fei Guo, Celia Sigua, Jianguo Tao, Purva Bali, Prince George, Yunqing Li, Sylvie Wittmann, Lynn Moscinski, Peter Atadja, Kapil Bhalla
Journal: Cancer Research (2004)

Present studies demonstrate that treatment with the histone deacetylases inhibitor LAQ824, a cinnamic acid hydroxamate, increased the acetylation of histones H3 and H4, as well as induced p21(WAF1) in the human T-cell acute leukemia Jurkat, B lymphoblast SKW 6.4, and acute myelogenous leukemia HL-60 cells. This was associated with increased accumulation of the cells in the G(1) phase of the cell cycle, as well as accompanied by the processing and activity of caspase-9 and -3, and apoptosis. Exposure to LAQ824 increased the mRNA and protein expressions of the death receptors DR5 and/or DR4, but reduced the mRNA and protein levels of cellular FLICE-inhibitory protein (c-FLIP). As compared with treatment with Apo-2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or LAQ824 alone, pretreatment with LAQ824 increased the assembly of Fas-associated death domain and caspase-8, but not of c-FLIP, into the Apo-2L/TRAIL-induced death-inducing signaling complex. This increased the processing of caspase-8 and Bcl-2 interacting domain (BID), augmented cytosolic accumulation of the prodeath molecules cytochrome-c, Smac and Omi, as well as led to increased activity of caspase-3 and apoptosis. Treatment with LAQ824 also down-regulated the levels of Bcl-2, Bcl-x(L), XIAP, and survivin. Partial inhibition of apoptosis due to LAQ824 or Apo-2L/TRAIL exerted by Bcl-2 overexpression was reversed by cotreatment with LAQ824 and Apo-2L/TRAIL. Significantly, cotreatment with LAQ824 increased Apo-2L/TRAIL-induced apoptosis of primary acute myelogenous leukemia blast samples isolated from 10 patients with acute myelogenous leukemia. Taken together, these findings indicate that LAQ824 may have promising activity in augmenting Apo-2L/TRAIL-induced death-inducing signaling complex and apoptosis of human acute leukemia cells.
Effect of ACTH and Adrenocortical Steroids on External Pancreatic Secretion in Man
Authors: David A. Dreiling, Henry D. Janowitz, Harold Rolbin
Journal: New England Journal of Medicine (1958)

A RELATION between pituitary-adrenal activity and the functional integrity of the exocrine pancreatic parenchyma has been suggested by a number of experimental studies1 2 3 4 and by clinical observations of benefit derived from the administration of ACTH and adrenocortical steroids in the therapy of pancreatic inflammation.5 6 7 The present study was undertaken to determine the effect of intravenously administered ACTH and the adrenal steroids upon the external pancreatic secretion in man.MethodFifty-nine patients in all were studied. Of these, there were 28 patients without signs or symptoms of pancreatic disease and 31 patients with proved pancreatic inflammatory disease. All patients were examined . . .
Inhibition of Polymorphonuclear Leukocyte–Mediated Graft Damage Synergizes With Short-Term Costimulatory Blockade to Prevent Cardiac Allograft Rejection
Authors: Tarek El-Sawy, John A. Belperio, Robert M. Strieter, Daniel G. Remick, Robert L. Fairchild
Journal: Circulation (2005)

Background— The early inflammatory response during reperfusion of cardiac allografts is initiated by the infiltration of polymorphonuclear leukocytes (PMNs) into the graft. The impact of early PMN infiltration on allograft rejection compared with long-term graft survival remains poorly understood. Methods and Results— We tested the role of CXCR2, the receptor for 2 PMN attractant chemokines, KC/CXCL1 and MIP-2/CXCL2, on intragraft inflammation and vascularized cardiac allograft rejection in a murine model. Compared with allografts retrieved from control recipients, both PMN infiltration and intragraft proinflammatory cytokine expression were significantly attenuated in allografts from CXCR2-antisera–treated wild-type or from CXCR2 −/− recipients. Adoptive transfer of alloantigen-primed T cells rapidly infiltrated and rejected allografts in control recipients, but T-cell infiltration was significantly decreased in recipients depleted of PMNs at transplantation. The influence of early PMN-mediated inflammation on the therapeutic efficacy of costimulatory blockade to prevent allograft rejection was tested. Short-term treatment of recipients with anti-CD154 mAb or CTLA-4 Ig induced modest prolongation of cardiac allograft survival. However, CD154 mAb or CTLA-4 Ig treatment, combined with either peritransplantation PMN depletion or antibodies specific for KC/CXCL1 plus MIP-2/CXCL2, prolonged cardiac allograft survival beyond 100 days. Conclusions— Results suggest that strategies attenuating PMN-mediated tissue damage during reperfusion significantly improve the efficacy of short-term costimulatory blockade to prevent T-cell–mediated rejection of cardiac allografts.
828. Optimizing the Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element (WPRE) for Safety and Function in Lentiviral Vectors
Authors: Manij Patel, John C. Olsen
Journal: Molecular Therapy (2005)

We have been developing a gene transfer system based on the non-primate lentivirus equine infectious anemia virus (EIAV) for human gene transfer. Previously, we reported that recombinant EIAV vectors pseudotyped with the G-glycoprotein of the vesicular stomatitis virus (VSV) are able to efficiently transduce muscle, hematopoietic, and neuronal cells. The vector has been optimized for vector titers and trans-gene expression in transduced cells by incorporating various cis-acting elements (EIAV Rev responsive element (RRE), Mason Pfizer monkey transport element (CTE), post-transcriptional regulatory element from woodchuck hepatitis virus (WPRE)) into the vector. The optimal vector configuration resulted in placement of the RRE upstream of the internal promoter and the WPRE into the 3-prime untranslated region downstream of the reporter gene. Although this configuration of vector yields the highest viral titers and transgene protein expression in target cells, safety concerns have been raised regarding the potential oncogenic activity of the truncated WHV X protein encoded in this element (Kingsman et al, Gene Therapy 12, 3, 2005). The WPRE used in our vectors is a 900 bp tripartite element described by Donello et al (J Virol, 78, 5085, 1998). The gamma and the alpha sub-elements provide the majority of the post-transcriptional effects on localization of viral RNA with some contribution from the beta sub-element which also encodes the WHV X protein, the function of which is still not clearly understood. To test whether the X protein is being expressed from our constructs, we fused a luciferase reporter gene in frame with the X protein. Luciferase activity was observed in transduced cells, which clearly suggests that the truncated X protein is being expressed. We are determining the levels of expression in primary human hepatocytes and in transduced mouse liver. We have constructed a minimal WPRE sequence of 513 bp that retains its complete cis-acting function. This element contains a 32 amino acid portion of protein X. We are currently making mutations in the protein X promoter which is a 21 nucleotide domain immediately upstream of the ATG codon of protein X and mutating the start codon and X ORF to prevent any aberrant X protein expression in target cells.
Sorting Things Out: Classification and Its Consequences
Authors: J. Marc Overhage, Jeffery G. Suico
Journal: Annals of Internal Medicine (2001)

Medical Writings: Book Notes20 November 2001Sorting Things Out: Classification and Its ConsequencesJ. Marc Overhage, MD, PhD and Jeffery G. Suico, MDJ. Marc Overhage, MD, PhDRegenstrief Institute for Health Care, Indiana University School of Medicine, Indianapolis, IN.Search for more papers by this author and Jeffery G. Suico, MDRegenstrief Institute for Health Care, Indiana University School of Medicine, Indianapolis, IN.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-10-200111200-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Bowker GC and Star SL. 389 pages. Cambridge, MA, and London: MIT Pr; 1999. $29.95. ISBN 0262024616. Order phone 800-356-0343.Field of medicine: Public health and medical informatics.Format: Hardcover book (softcover also available).Audience: Physicians and nonphysicians involved in developing or setting policy for classification systems, nomenclatures, or vocabularies.Purpose: To discuss the idea that classifications and standardizations have direct impact on social and political aspects of human interaction.Content: The authors organize their presentation into an introductory chapter that frames the issues, followed by three sections (classification and large-scale infrastructures, classification and biography, and classification and work practice) ... Author, Article, and Disclosure InformationAffiliations: Regenstrief Institute for Health Care, Indiana University School of Medicine, Indianapolis, IN. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRevisiting Gendered Web Forms: An Evaluation of Gender Inputs with (Non-)Binary PeopleThe 18 benefits of using ecosystem services classification systemsHow Computers See Gender 20 November 2001Volume 135, Issue 10Page: 934KeywordsHealth careHealth informaticsInformation technologyInternational Classification of DiseasesPrevention, policy, and public healthRacial and ethnic issuesSoftware tools ePublished: 20 November 2001 Issue Published: 20 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Partial matching theory and the memory span
Authors: David J. Murray
Journal: Behavioral and Brain Sciences (2001)

Partial matching theory, which maintains that some memory representations of target items in immediate memory are overwritten by others, can predict both a “theoretical” and an “actual” maximum memory span provided no chunking takes place during presentation. The latter is around 4 ± 2 items, the exact number being determined by the degree of similarity between the memory representations of two immediately successive target items.