tbuckley/cabot-search huggingface dataset:
Specific sensitization to the common housefly (<i>Musca domestica</i>) not related to insect panallergy
Authors: M. Focke, W. Hemmer, S. Wöhrl, M. Götz, R. Jarisch, H. Kofler
Journal: Allergy (2003)

Background: Allergy to houseflies is rare. We report a case of respiratory allergy from occupational exposure to houseflies in a farmer. Case report: A 30 year‐old female farmer with a long‐standing history of grass pollen allergy observed for 2 years rhino‐conjunctivitis and mild asthma when entering livestock stables and barns. Allergy retesting revealed sensitization to various pollens but not to animal danders. Houseflies ( Musca domestica ) occurring on the farm in great quantity were suspected by the farmer herself as the causative agent. Results: Skin prick testing with housefly was positive in the patient and negative in four controls. Experimental radioallergosorbant test was class 3 positive. Sensitization to house dust mite, storage mites and cockroach was not detectable. Western blots with housefly extracts revealed immunoglobulin E (IgE)‐binding to bands of 70, 50, and approximately 16 kDa. Tropomyosin in the housefly extract (35 kDa) was recognized by a tropomyosin reference serum but not by the patient. In enzyme‐linked immunosorbent assay (ELISA) inhibition assays using housefly as the solid phase, IgE‐binding of the patient was inhibited by 75% by M. domestica and by 44% by the closely related lesser housefly ( Fannia canicularis ), but not by extracts from blowfly ( Lucilia spp.), fruit fly ( Drosophila spp.), horsefly ( Haematopota pluvialis ) and mosquito ( Culex pipiens ). The IgE‐binding of the tropomyosin control serum was inhibited by 60–80% by all species. Conclusions: In accordance with previous reports, this case demonstrates that respiratory sensitization to insects may be highly specific. According to ELISA inhibition, cross‐sensitization in the present case was restricted to species of the family of true flies ( Muscidae ).
KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
Authors: Jianhua Ling, Ya'an Kang, Ruiying Zhao, Qianghua Xia, Dung-Fang Lee, Zhe Chang, Jin Li, Bailu Peng, Jason B. Fleming, Huamin Wang, Jinsong Liu, Ihor R. Lemischka, Mien-Chie Hung, Paul J. Chiao
Journal: Cancer Cell (2012)
Myeloid‐specific disruption of recombination signal binding protein Jκ ameliorates hepatic fibrosis by attenuating inflammation through cylindromatosis in mice
Authors: Fei He, Feng‐Cheng Guo, Zhi Li, Heng‐Chao Yu, Peng‐Fei Ma, Jun‐Long Zhao, Lei Feng, Wei‐Na Li, Xiao‐Wei Liu, Hong‐Yan Qin, Ke‐Feng Dou, Hua Han
Journal: Hepatology (2014)

Macrophages play multidimensional roles in hepatic fibrosis, but their control has not been fully understood. The Notch pathway mediated by recombination signal binding protein Jκ (RBP‐J), the transcription factor transactivated by signals from four mammalian Notch receptors, is implicated in macrophage activation and plasticity. In this study, by using mouse hepatic fibrosis models, we show that myeloid‐specific disruption of RBP‐J resulted in attenuated fibrosis. The activation of hepatic stellate cells and production of profibrotic factors including platelet‐derived growth factor (PDGF)‐B and transforming growth factor beta1 (TGF‐β1) reduced significantly in myeloid‐specific RBP‐J deficient mice. The infiltration of inflammatory cells and production of proinflammatory factors were reduced in liver of myeloid‐specific RBP‐J‐deficient mice during fibrosis. In RBP‐J‐deficient macrophages, the nuclear factor kappa B (NF‐κB) activation was remarkably attenuated as compared with the control. This could be attributed to the up‐regulation of cylindromatosis (CYLD), a negative regulator of NF‐κB, in Notch signal‐compromised macrophages, because the knockdown of CYLD in RBP‐J‐deficient macrophages or overexpression of p65 in RBP‐J knockdown cells both restored NF‐κB activation and the production of proinflammatory and/or profibrotic factors by macrophages. In human hepatic fibrosis biopsies, stronger Notch activation is correlated with more severe fibrosis, which is accompanied by a lower level of CYLD but irrespective of etiological reasons. Conclusion : RBP‐J‐mediated Notch signaling is required for macrophages to promote hepatic fibrosis by up‐regulation of NF‐κB activation through CYLD. (H epatology 2015;61:303–314)
Dose-Intense Paclitaxel: Déjà Vu All Over Again?
Authors: Chris H. Takimoto, Eric K. Rowinsky
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.05.099 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12807932 Dose-Intense Paclitaxel: Déjà Vu All Over Again? Chris H. TakimotoxChris H. TakimotoSearch for articles by this author , Eric K. RowinskyxEric K. RowinskySearch for articles by this author Show More Institute for Drug Development, Cancer Therapy and Research Center, and University of Texas Health Science Center, San Antonio, TX https://doi.org/10.1200/JCO.2003.05.099 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
The Christmas tree sign: a diagnostic tool for ECG connoisseurs
Authors: C. M. Plymen, G. S. Carr-White, S. Kapetanakis
Journal: BMJ (2014)

Sometimes challenging, electrocardiograms (ECGs) can often provide invaluable information for those willing to look closely. However, we suggest a way of reading ECGs that has been neglected for more than 100 years. The …
Control of Health-Care Costs
Authors: Mitchell T. Rabkin
Journal: New England Journal of Medicine (1983)

Economic incentives are recognized as a major influence on the delivery and cost of health care. This does not mean that physicians, hospitals, and other providers of care are motivated primarily by dollar considerations. It means, rather, that in prescribing and receiving health care there is a wide range of possible uses of resources and thus of potential costs. Much of health care today is immune to the economic forces that shape more conventional markets; properly arranged, these forces can benefit both buyer and seller. In this essay, I advocate a coordinated system of payment principles, using specifically targeted incentives . . .
Climate, traffic-related air pollutants, and asthma prevalence in middle-school children in taiwan.
Authors: Y L Guo, Y C Lin, F C Sung, S L Huang, Y C Ko, J S Lai, H J Su, C K Shaw, R S Lin, D W Dockery
Journal: Environmental Health Perspectives (1999)

This study compared the prevalence of asthma with climate and air pollutant data to determine the relationship between asthma prevalence and these factors. We conducted a nationwide survey of respiratory illness and symptoms in middle-school students in Taiwan. Lifetime prevalences of physician-diagnosed asthma and of typical symptoms of asthma were compared to air monitoring station data for temperature, relative humidity, sulfur dioxide, nitrogen oxides, ozone, carbon monoxide, and particulate matter with aerodynamic diameter [less than/equal to] 10 microm (PM(10)). A total of 331,686 nonsmoking children attended schools located within 2 km of 55 stations. Asthma prevalence rates adjusted for age, history of atopic eczema, and parental education were associated with nonsummer (June-August) temperature, winter (January-March) humidity, and traffic-related air pollution, especially carbon monoxide and nitrogen oxides, for both girls and boys. Nonsummer temperature, winter humidity, and traffic-related air pollution, especially carbon monoxide and nitrogen oxides, were positively associated with the prevalence of asthma in middle-school students in Taiwan.
Airway smooth muscle in health and disease; methods of measurement and relation to function
Authors: A. James, N. Carroll
Journal: European Respiratory Journal (2000)

Smooth muscle is present and probably functional in the airways in utero and increases in absolute area during growth with little further change during adulthood. It encircles the entire airway below the level of the main bronchus, in a roughly circular orientation, except at high lung volumes. It occupies relatively more of the airway wall in the peripheral airways, reaching a maximum in the membranous bronchioles. Measurement of smooth muscle area in the airway wall is confounded by clinical classification of cases, methods of tissue retrieval and preparation, staining and orientation of sections, magnification, image analysis and statistical methods of comparison between groups. Airway smooth muscle area is pathologically increased in inflammatory conditions of the airways such as chronic obstructive pulmonary disease, in relation to airways obstruction, and asthma, in relation to severity and airway size (between 25 and 250% compared with control cases). It is increased in sudden infant death syndrome, but there are few studies in other conditions such as bronchiectasis. In asthma, smooth muscle must shorten (not necessarily to an abnormal degree) for the structural abnormalities of the airway to manifest as excessive airway narrowing. Not surprisingly there is renewed interest in the relationships between the mechanical and contractile properties of smooth muscle, parenchymal properties and lung volume and how these interact to determine smooth muscle length. The relative importance of smooth muscle area and mechanical properties, altered airway structure and airway inflammation in disease are yet to be determined.
Budget Impact and Sustainability of Medical Care Management for Persons With Serious Mental Illnesses
Authors: Benjamin G. Druss, Silke A. von Esenwein, Michael T. Compton, Liping Zhao, Douglas L. Leslie
Journal: American Journal of Psychiatry (2011)

The authors assessed the 2-year outcomes, costs, and financial sustainability of a medical care management intervention for community mental health settings.A total of 407 psychiatric outpatients with serious mental illnesses were randomly assigned to usual care or to a medical care manager who provided care coordination and education. Two-year follow-up chart reviews and interviews assessed quality and outcomes of care, as well as costs from both the health system and managerial perspectives.Sustained improvements were observed in the intervention group in quality of primary care preventive services, quality of cardiometabolic care, and mental health-related quality of life. From a health system perspective, by year 2, the mean per-patient total costs for the intervention group were $932 (95% CI=-1,973 to 102) less than for the usual care group, with a 92.3% probability that the program was associated with lower costs than usual care. From the community mental health center perspective, the program would break even (i.e., revenues would cover setup costs) if 58% or more of clients had Medicaid or another form of insurance. Given that only 40.5% of clients in this study had Medicaid, the program was not sustainable after grant funding ended.The positive long-term outcomes and favorable cost profile provide evidence of the potential value of this model. However, the discrepancy between health system and managerial cost perspectives limited the program's financial sustainability. With anticipated insurance expansions under health reform, there is likely to be a stronger business case for safety net organizations considering implementing evidence-based interventions such as the one examined in this study.
Royal Free disease: perplexity continues.
Authors: J Dawson
Journal: BMJ (1987)

velocity ofinflow.The observations also account for the third heart sound in left ventricular failure and constrictive pericarditis because ventricular relaxation is incomplete in both conditions, causing sudden deceleration of inflow.9Age related changes in the kinetics of ventricular relaxa- tion provide a plausible explanation for the physiological third heart sound disappearing in adults.7In children and young adults the left ventricle is thin and relaxes rapidly, ensuring the high inflow velocity that generates the third heart sound.With advancing age, however, the left ventri- cular mass increases, possibly because of rising blood pressure.The thickened ventricle relaxes more slowly thus reducing inflow velocity and ultimately causing the physiological third heart sound to disappear.
Risks of Valve Replacements in Young Women
Authors: John J. Collins
Journal: Circulation (1999)

ttempts to evaluate performance of cardiac valves by retrospective analysis are notoriously difficult because of the complexity associated with preoperative illnesses, types of replacement valves available or used, use of anticoagulant medications in some but not all patients, and a myriad of other differences.When a diverse group of women having multicultural backgrounds receive valves under various circumstances and at various intracardiac locations over an interval of Ն20 years, the difficulty of showing by rigorous statistical techniques that differences in individual outcomes are related to demonstrable or predictable circumstances relating to the valve is very great.
Design of a gastroretentive mucoadhesive dosage form of furosemide for controlled release
Authors: Sharad S. Darandale, Pradeep R. Vavia
Journal: Acta Pharmaceutica Sinica B (2012)

The aim of the present study was to develop and characterize a gastroretentive dosage form suitable for controlled drug release. It consists of a drug loaded polymeric film made up of a bilayer of immediate (IR) and controlled release (CR) layers folded into a hard gelatin capsule. Gastroretention results from unfolding and swelling of the film and its bioadhesion to the gastric mucosa. Furosemide, a drug with a narrow absorption window, was selected as the model drug. Inclusion of hydroxypropyl β-cyclodextrin in both layers and Carbopol® 971P NF in the CR layer of the bilayer film resulted in optimum drug release, bioadhesion and mechanical properties. The film with zig-zag folding in the capsule was shown to unfold and swell under acidic conditions and provide IR of drug over 1 h and CR for up to 12 h in acidic medium. X-ray diffraction, differential scanning calorimetry and scanning electron microscopy revealed uniform dispersion of furosemide in the polymeric matrices. The results indicate the dosage form is gastroretentive and can provide controlled release of drugs with narrow therapeutic windows.
P97 Optimising management and improving outcomes in chronic obstructive pulmonary disease by integrating care
Authors: E. J. Cetti, E. Vijaykumar
Journal: Thorax (2011)

<h3>Introduction/Objectives</h3> Previous integrated care models for COPD have reduced length of stay slightly1 or improved patient quality of life. In this study a pathfinder consortium of 20 practices and the local acute hospital, implemented a collaborative project with a partner from the pharmaceutical industry to improve COPD outcomes. The aims were to reduce hospital admissions, re-admissions and length of stay by integrating care via a patient focussed pathway. <h3>Methods</h3> A care pathway was developed, involving patients, that crossed primary and secondary care boundaries and led to improved access to community respiratory services. In each practice patients with COPD were stratified by risk and reviewed by trained nurses, in a structured format. Practice Nurse educational needs were assessed and a mentorship programme put in place. A Consultant Respiratory Physician from the local hospital visited the practices to discuss COPD management and the care pathway, and now runs on-going education and support. National medicine management guidelines were adhered to and reinforced with all healthcare professionals. The links between primary care and the community respiratory team were enhanced and clear referral guidelines were disseminated. The local patient support group (Breathe Easy) was re-launched. <h3>Results</h3> Patients were satisfied with the structured nurse-led COPD reviews, 463/487 said they were “very satisfied”, and 433/487 said they were “totally aware” of their self-management plan. There was a 21% reduction in COPD hospital bed days and the average length of stay fell from 6.8 days to 5.0 days. At the end of 2010 the 30 day re-admission rate had fallen below the Strategic Health Authority average. Over the 12 months of the project the 90 day re-admission rate fell from 43% to 31%, a 12% reduction not shown previously elsewhere1—see Abstract P97 figure 1. <h3>Conclusions</h3> By engaging with all aspects of COPD care, an integrated multidisciplinary team improved service delivery and patient care, reducing COPD hospital bed days and re-admission rates. If the current proposed NHS reforms offer an opportunity for better integrated healthcare then they may deliver improved outcomes.
Propranolol does not alter cerebral blood flow and functions in cirrhotic patients without previous hepatic encephalopathy
Authors: Paul Calès, Max Pierre-Nicolas, Antonio Guell, Jean-Louis Mauroux, Anne Franco-Sempe, Jean-Pierre Vinel, Gilles Geraud, Jean-Pierre Pascal
Journal: Hepatology (1989)

Since it has been suggested that propranolol could lead to hepatic encephalopathy, we undertook a study to assess the effects of propranolol on cerebral blood flow and cerebral functions. Sixteen patients with alcoholic cirrhosis and large esophageal varices and without major hepatic dysfunction (Child-Pugh score &lt;14) or previous hepatic encephalopathy were randomized to receive either propranolol or placebo. The following measurements weré performed before and 15 min after single intravenous administration of 15 mg propranolol or placebo and again 1 week after chronic oral administration of propranolol 160 mg per day or placebo: cerebral blood flow by the xenon-133 inhalation technique, quantitative electroencephalogram, psychometric test (number connection test), arterial ammonia, pH and pCO 2 , resting and exercise heart rates (after single administration, electroencephalogram, number connection test and biochemical measurements were not performed). Cerebral blood flow was not significantly modified by treatment (propranolol group: 80 ± 23 vs. 76 ± 11 and 83 ± 9; placebo group: 73 ± 10 vs. 75 ± 11 and 81 ± 18 ml per 100 gm per min, respectively, before and after single and repeated administration). Likewise, neither of the two treatments significantly altered number connection test, quantitative electroencephalogram index, arterial ammonia, pH and pCO 2 . We conclude that, in this population of cirrhotic patients, propranolol did not alter cerebral blood flow or neuropsychological functions. As a consequence, hemodynamic alterations cannot be considered as causes of possible cerebral side effects of propranolol in cirrhotic patients without severe hepatic dysfunction and previous hepatic encephalopathy.
Abstract 5133: Identification of FC101-interacting proteins by immunoprecipitation
Authors: Dominique C. Washington, Amber D. Williams, Tara Williams-Hart
Journal: Cancer Research (2014)

Abstract Fusarochromanone (FC 101) is a small toxic metabolite produced by Fusarium equiseti, a fungus found on decaying cereal plants and food grains. FC101 has been shown to exhibit anti-angiogenic and anti-cancer activity on various mammalian cells. Previous studies have revealed that FC101 inhibits growth of 35 human cancer cells and reduces mouse tumor size almost two-fold with increased caspase3 expression in FC101-treated tumors. cDNA microarray analysis and RT-qPCR were used to identify differentially expressed genes in human bladder cancer cell lines (UM-UC14) and Saccharomyces cerevisiae (budding yeast) exposed to different concentrations of FC101. These genes encode proteins that represent possible molecular targets of FC101. The objective of this study is to identify proteins that interact with FC101 by immunopercipitation using an FC101 antibody in UM-UC14 cells. We predict FC101 molecular targets will be verified in future animal studies and eventually FC101 may be used as a chemotherapeutic agent. Citation Format: Dominique C. Washington, Amber D. Williams, Tara Williams-Hart. Identification of FC101-interacting proteins by immunoprecipitation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5133. doi:10.1158/1538-7445.AM2014-5133
Emergency Psychiatric Treatment During a Mass Rally: The March on Washington
Authors: WILLIAM T. CARPENTER, NORMAN R. TAMARKIN, DAVID E. RASKIN
Journal: American Journal of Psychiatry (1971)

The authors present a rationale for establishing emergency psychiatric facilities during mass demonstrations. Special aspects or attributes such as trust, confidentiality, the authoritarian role of the physician, legal complications, the management of potentially violent patients, and the evaluation of thought processes are discussed. The low incidence of psychiatric casualties and the relative rarity of adverse drug reactions during the November 1969 March on Washington are documented: the majority of the most disturbed patients came to Washington for idiosyncratic reasons and did not regard themselves as antiwar protestors.
Do it yourself thermotherapy
Authors: Jacqueline Buijs, Rinske Boersma
Journal: BMJ (2006)

A 75 year old man was found unconscious in his bath. He had had a coronary bypass operation and pacemaker implanted because of syncope with bradyarrhythmia, and, more recently, prostate carcinoma with bone metastases had been diagnosed, for which he was being treated with antiandrogens. Examination revealed an unresponsive patient with a Glasgow coma score of 1-1-1, …
Influenza in Goodpasture's Syndrome?
Authors: JOHN MILLS
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 October 1972Influenza in Goodpasture's Syndrome?JOHN MILLS, M.D.JOHN MILLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-662 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The patient reported by Wilson and Smith (Ann Intern Med76:91-94, 1972) appears to have well-documented Goodpasture's syndrome. However, the diagnosis of influenza virus infection is open to serious question. The brief clinical history presented, although consistent with influenza, is also typical of Goodpasture's syndrome. One would have liked further details of the methods used for "serologic studies," in view of their central importance in viral diagnosis in this paper; but, assuming that the titers were measured by the hemagglutination-inhibition or neutralization techniques, which are the methods most consistent with the values given (1), several inconsistencies are...References1. VAN KIRKMILLSCHANOCK JJR: Evaluation of low temperature grown influenza A2-Hong Kong virus in volunteers. Proc Soc Exp Biol Med 136:34-41, 1971 CrossrefMedlineGoogle Scholar2. BLUMENFELDKILBOURNELOURIA HED: Studies on influenza in the pandemic of 1957-58. I. An epidemiologic, clinical and serologic investigation of an intrahospital epidemic, with a note on vaccination efficacy. J Clin Invest 38:199, 1959 CrossrefMedlineGoogle Scholar3. KNIGHTKASALALFORD VJR: New research on influenza: studies with normal volunteers. Ann Intern Med 62:1307-1325, 1965 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco General Hospital University of California, San Francisco San Francisco, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1972Volume 77, Issue 4Page: 662-663 Issue Published: 1 October 1972 PDF DownloadLoading ...