tbuckley/cabot-search huggingface dataset:
Abstract 2125: G-protein coupled receptors for cholecystokinin regulate transactivation of EGF receptors in lung cancer cells
Authors: Terry W. Moody, Suk Hee Lee, Paola Moreno Perez, Robert T Jensen
Journal: Cancer Research (2014)

Abstract Cholecystokinin (CCK) receptors (CCK-AR and CCK-BR) are G-protein coupled receptors (GPCR) which are present on lung cancer cells (Yoder and Moody, Peptides 1987; 8: 103). CCK stimulates the proliferation of NCI-H345 cells, whereas the CCK-B receptor antagonist CI-988 inhibits proliferation (Moody et al., JPET 2001; 299: 1154). Peptide receptors for some gastrointestinal hormones/neurotransmitters mediate lung cancer growth by causing EGFR transactivation, but it is unknown if this occurs with CCK-BR. CCK-BR mRNA was detected in NCI-H345 and H727 lung cancer cells. Addition of CCK-8 or gastrin I (100 nM) to NCI-H345 or H727 cells, which have wild type EGFR, increased EGFR Tyr1068 phosphorylation after 5 min. The ability of CCK-8 to cause EGFR or ERK tyrosine phosphorylation was blocked by CI-988 (CCK-BR antagonist), gefitinib (EGFR tyrosine kinase inhibitor), PP2 (Src inhibitor), GM6001 (matrix metalloprotease inhibitor), tiron (superoxide scavenger) and U-73122 (phospholipase C inhibitor) but not H89 (protein kinase A inhibitor). U-73122 or CI-988 inhibited the ability of CCK to cause phosphatidylinositol turnover and elevate cytosolic Ca2+. CI-988 or gefitinib inhibited the growth of NCI-H345 or H727 cells. CI-988 and gefitinib synergistically inhibited the growth of lung cancer cells. The results indicate that the CCK-BR regulates lung cancer proliferation in an EGFR-dependent mechanism through activation of Src, MMP and reactive oxygen species. Citation Format: Terry W. Moody, Suk Hee Lee, Paola Moreno Perez, Robert T Jensen. G-protein coupled receptors for cholecystokinin regulate transactivation of EGF receptors in lung cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2125. doi:10.1158/1538-7445.AM2014-2125
Physiological Basis of Myocardial Contrast Enhancement in Fast Magnetic Resonance Images of 2-Day-Old Reperfused Canine Infarcts
Authors: Robert M. Judd, Carlos H. Lugo-Olivieri, Masazumi Arai, Takeshi Kondo, Pierre Croisille, Joao A.C. Lima, Vivek Mohan, Lewis C. Becker, Elias A. Zerhouni
Journal: Circulation (1995)

Background Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonstrate regions of hypoenhancement and hyperenhancement. The relations between the spatial extent and time course of these enhancement patterns to myocardial risk, infarct, and no-reflow regions have not been well characterized. Methods and Results The proximal left anterior descending coronary artery was occluded in 11 closed-chest dogs for 90 minutes followed by 2 days of reperfusion. Regional blood flow was determined by use of radioactive microspheres. The animals were studied at the 2-day time point with contrast-enhanced fast MRI (Signa 1.5 T, General Electric). Thioflavin-S was administered to demarcate no-reflow regions. The hearts were then excised, sectioned into five base-to-apex slices, stained with 2,3,5-triphenyltetrazolium chloride (TTC), and photographed under room light (for TTC) and ultraviolet light (for thioflavin). The spatial extents of thioflavin-negative, TTC-negative, and risk regions were compared planimetrically with MRI hypoenhanced and hyperenhanced regions. The spatial locations of subendocardial hypoenhancement in MR images correlated closely with those of thioflavin-negative regions. Microsphere blood flow in these regions was significantly reduced compared with remote regions (0.37±0.09 versus 0.88±0.10 mL/min per gram, respectively, P &lt;.001) and with baseline (0.37±0.09 versus 0.87±0.15 mL/min per gram, P &lt;.01). The spatial extent of hyperenhancement was smaller than the risk region ( r =.64, slope=0.48, P &lt;.001) but highly correlated with TTC-negative regions and were, on average, 12% larger ( r =.93, slope=1.12, P =.035). Conclusions In contrast-enhanced MR images of 2-day-old reperfused canine infarcts, myocardial regions of hypoenhancement are related to the no-reflow phenomenon. Approximately 90% of the myocardium within hyperenhanced regions is nonviable.
Bristol Royal Infirmary. PISTOL-SHOT WOUND OF THE CHEST: WOUND OF THE HEART AND STOMACH
Authors: A. Prichard
Journal: BMJ (1855)

I WAS sent for about half-past twelve o'clock in the night of Saturday, the 20th of October last, to see a patient, W. B., aged 28, who had just been brought to the Bristol Royal Infirmary with a pistol-shot in the chest.From the ac- count given at the time, and from his own statement, as well as from the evidence given after his death at the coroner's inquest, it appears that he had been shooting with a long-barreled rifled pistol, at one ofthe galleries in the town; and that, after a few shots, he sent the owner of the gallery to rectify something supposed to be wrong at the target, but that immediately afterwards a pistol-shot was heard, and he was found lying on the ground, writhing in Pain.He stated that he was examining the cap and the nipple of the lock, and it accidentally went off.When I saw him first, he was lying in bed, gasping for breath, and fainting; he was covered with blood, and had a round hole in the left side of the chest, between the fifth and sixth ribs, about four inches to the left of the middle line, cor- Tesponding to a similar hole in his waistcoat, and the three shirts he had on at the time of receiving the injury.The direction in which the hole led appeared to be downwards, and inwards, and backwards.The little finger could be readily passed in, and something like the beating of the heart could be felt.
Pulsed Doppler echocardiographic determination of stroke volume and cardiac output: clinical validation of two new methods using the apical window.
Authors: J F Lewis, L C Kuo, J G Nelson, M C Limacher, M A Quinones
Journal: Circulation (1984)

Two methods of measuring stroke volume and cardiac output with pulsed Doppler two-dimensional echocardiography were developed and validated against the thermodilution technique in 39 patients, 33 of which were in an intensive care unit. With the use of the apical four-chamber view, a mitral inflow method combined the velocity of left ventricular inflow at the mitral anulus with the cross-sectional area of the anulus calculated from its diameter at middiastole (area = pi r2). From the apical five-chamber view a left ventricular outflow method combined the velocity of left ventricular outflow with the cross-sectional area of the aortic anulus calculated from its diameter during early systole (parasternal long-axis view). Measurements with the mitral inflow and left ventricular outflow methods were obtained in 35 of 39 (90%) and 39 of 39 (100%) patients, respectively. Validation of the mitral method excluded patients with mitral regurgitation (n = 11) and validation of the left ventricular outflow method excluded those with aortic regurgitation (n = 4). Good correlations were observed between thermodilution and Doppler measurements of stroke volume and cardiac output for both the mitral anulus method (R = .96 and .87, respectively) and the left ventricular outflow method (R = .95 and .91, respectively). The results of the two methods correlated well with each other in patients without regurgitant valve lesions. A greater interobserver variability was observed with the mitral anulus method, which was related solely to greater variability in measuring the annular diameter.(ABSTRACT TRUNCATED AT 250 WORDS)
Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft function
Authors: E.C. Aquino-Dias, G. Joelsons, D.M. da Silva, R.H. Berdichewski, A.R. Ribeiro, F.J.V. Veronose, L.F. Gonçalves, R.C. Manfro
Journal: Kidney International (2008)
Pertechnetate Thyroid Uptake Is Not Always Suppressed in Patients With Subacute Thyroiditis
Authors: CHIAKI SHIGEMASA, SACHIKO TESHIMA, SHINICHI TANIGUCHI, YOSHIHIKO UETA, YASUO MITANI, AKIO YOSHIDA
Journal: Clinical Nuclear Medicine (1997)

The authors studied the clinical courses and immunologic aspects in 15 patients (age range, 32-69 years old; 14 women) with clinical features that were similar to subacute thyroiditis (SAT). In 2 patients (group A) whose thyrotropin-binding inhibitory immunoglobulins (TBII) and thyroid stimulating antibody (TSAb) showed strongly positive activity at the initial visit, Tc-99m pertechnetate thyroid uptake (Tc-99m uptake) was elevated (5.6% and 3.8%, respectively, normal; 0.7-3.0%). In 6 (group B) of 13 other patients, Tc-99m uptake was not completely suppressed (2 normal, 4 near normal) and imaging showed uptake in one lobe. In 7 (group C), however, there was no evidence of uptake in either lobe. Inflammatory process was localized in one lobe in all group B patients, and was in both lobes in all group C patients but one. Serum TSH levels were detectable in at least 4 patients (2 group B, 2 group C) low in all. There were no patients in both groups B and C in whom TBII and/or TSAb were detected at the initial visit. In SAT, marked suppression of Tc-99m uptake may be ascribed mainly to inflammatory follicular cell damage, but it is not always suppressed, owing to an association similar to Graves' disease and other unknown mechanism(s).
Meningitis, Pneumonitis, and Arthritis Caused by Neisseria meningitidis Group Y
Authors: Ngai M. Yee
Journal: JAMA (1975)

Neisseria meningitidis subgroup Y, although commonly isolated from the nasopharynx, rarely has caused meningitis in nonmilitary individuals. Meningococcus (serogroup Y) caused pneumonitis, meningitis, and arthritis in a previously healthy woman. Findings from examination of spinal fluid were minimal, but the clinical aspects of the illness were similar to those seen with other meningococcal serotypes.
Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel
Authors: Hyun-Jong Cho, Hong Yeol Yoon, Heebeom Koo, Seung-Hak Ko, Jae-Seong Shim, Ju-Hee Lee, Kwangmeyung Kim, Ick Chan Kwon, Dae-Duk Kim
Journal: Biomaterials (2011)
Man-made Death
Authors: Giles R. Scofield
Journal: JAMA (1989)

<h3>To the Editor. —</h3> Mr Rhodes'<sup>1</sup>thoughtful essay entitled "Man-made Death: A Neglected Mortality" highlighed a significant concern, but overlooked a fundamental connection. Humanity has not "progressively mastered biologic death," but has instead become artful at using technology to manipulate the time and appearance of death. How technology is used, whether to prolong life, improve the world's food supply, or hasten death, is a matter of human judgment. A world accustomed or acceding to the driving force of technology will succumb to the urge to do something simply because it can be done. The dereliction of our responsibility to exercise judgment concerning the use of technology, whether nuclear or medical, makes up a good portion of the problem whose threat prompted Mr Rhodes' timely and justified concerns.
Fifty Breakthroughs for Sustainable Global Development
Authors: M. J. Friedrich
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ionizing Radiation in Cardiac Imaging
Authors: Thomas C. Gerber, J. Jeffrey Carr, Andrew E. Arai, Robert L. Dixon, Victor A. Ferrari, Antoinette S. Gomes, Gary V. Heller, Cynthia H. McCollough, Michael F. McNitt-Gray, Fred A. Mettler, Jennifer H. Mieres, Richard L. Morin, Michael V. Yester
Journal: Circulation (2009)
Sedative prescribing among older people doubles with move into residential care, finds study
Authors: C. White
Journal: BMJ (2013)

The proportion of older people who receive mood altering drugs increases sharply when they move into residential care, a rise that is not fully explained by prescribing rates before admission, a study from Northern Ireland has found.

The findings back up those of other studies in the United Kingdom and are likely to fuel concerns that drugs such as sedatives, tranquillisers, and antipsychotics may be being used as a form of “chemical cosh” among older people in residential care.

In the latest study, researchers from Queen’s University in Belfast drew on national prescribing data on the numbers of psychotropic drugs prescribed to all people aged 65 years or over in Northern Ireland between 2008 and 2010 and data on people’s moves into 345 …
RalA and RalB: Antagonistic Relatives in Cancer Cell Migration
Authors: Gary Oxford, Charles R. Owens, Brian J. Titus, Tonia L. Foreman, Mikael C. Herlevsen, Steven C. Smith, Dan Theodorescu
Journal: Cancer Research (2005)

Abstract The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of their high sequence homology. Here we analyze the separate contributions of RalA and RalB in regulating cell migration, a necessary component of the invasive phenotype, in two human cancer cell lines; UMUC-3, a bladder carcinoma line, and the prostate carcinoma line, DU145. Although inhibiting RalA protein expression by ∼80% with two different small interfering RNA duplexes had no effect on migration, inhibiting RalB expression to the same extent with two different duplexes resulted in a marked reduction in migration. Inhibiting RalB expression did trigger a significant loss of actin cytoskeleton fibers in UMUC-3 that was not seen with inhibition of RalA expression. Interestingly, simultaneous inhibition of RalA and RalB expression had no effect on migration. However, dual inhibition of RalA and RalB expression in UMUC-3 did result in an almost total loss of actin fibers as well as a reduction in proliferation, particularly in reduced serum conditions. These results suggest that RalA and RalB have different roles in cell migration and that they may in fact act as antagonists with regard to this phenotype. As further verification of this hypothesis, we found that expression of constitutively active RalA inhibited migration, whereas expression of constitutively active RalB stimulated migration, consistent with this model. In summary, we present the first demonstration that despite their significant sequence homology, RalA and RalB have nonoverlapping and opposing functions in cancer cell migration but overlapping functions in cell growth.
Successful long-term triple disease control by ustekinumab in a patient with Behçet's disease, psoriasis and hidradenitis suppurativa: Table 1
Authors: Ewout M Baerveldt, Jasper H Kappen, H Bing Thio, Jan AM van Laar, P Martin van Hagen, Errol P Prens
Journal: Annals of the Rheumatic Diseases (2012)

Behcet's disease (BD) is an auto-inflammatory disorder, characterised by recurrent oral aphtosis, genital ulcers, uveitis and pustular skin lesions.1 Associated cutaneous diseases include Sweet's syndrome,2 erythema nodosum and pyoderma gangrenosum.3 Next to BD, both psoriasis and hidradenitis suppurativa (HS) are clear neutrophilic and interleukin (IL)-17-based diseases, suggesting a pathomechanistic overlap.4–7 However, these diseases rarely co-occur.4 Ustekinumab (anti-p40 mAb), an effective biological treatment for psoriasis, might be effective in BD by interfering with the IL-17 signalling via IL-23 blockage. We present a 39-year-old Caucasian woman in whom the combination of BD, psoriasis and HS was successfully treated with ustekinumab.

At the age of 5, the …
Origin of the Caduceus Motif
Authors: John T. Bunn
Journal: JAMA (1967)

The caduceus motif is most ancient. Near Eastern archaeological finds from 3100 BC attest to the twin-snake design. Equally early is the single-snake design. Creation epics of the Near and Far East depict the snake as symbolical of the Agathodaemon or Kakodaemon, the good or the evil one. Other literary documents connect the snake with life, immortality, and the gods of healing. Both archaeological and literary evidences indicate that in most ancient times a snake rod or staff was utilized in the craft of healing.
The role of sodium influx during global ischemia on contracture myocardial injury
Authors: Hidetaka Iida, Masakazu Teragaki, Iku Toda, Mitsutaka Yasuda, Kaname Akioka, Kazuhide Takeuchi, Tadanao Takeda, Makoto Ishikawa, Iwao Miura
Journal: Journal of the American College of Cardiology (1991)
Transvenous Cardiac Pacing. Experience of a Percutaneous Supraclavicular approach
Authors: M. B. Macaulay, J. S. Wright
Journal: BMJ (1970)

A detailed description is given of a technique for the introduction of cardiac pacing catheters using a percutaneous supraclavicular route through the subclavian vein. In 91 attempts there was only one failure and the frequency of complications was low. Surface landmarks for the procedure were easy to define precisely, and stable pacing could usually be established rapidly without distress to the patient or subsequent immobilization of any limb. It is suggested that operators with little experience of cardiac catheterization might find this approach valuable in the emergency pacing of acute heart block. Subclavian venepuncture does not appear to be as hazardous as has previously been suggested.
Radioguided Parathyroidectomy for Recurrent Parathyroid Cancer
Authors: Kimberly Placzkowski, Rose Christian, Herbert Chen
Journal: Clinical Nuclear Medicine (2007)

We report a case of radioguided parathyroidectomy in a patient with parathyroid carcinoma. A 61-year-old woman presented to our center with persistent hypercalcemia (17.2 mg/dL) and hyperparathyroidism (PTH=324 pg/mL) following her second neck resection for recurrent parathyroid carcinoma at an outside facility. Her elevated serum calcium had not responded to treatment with intravenous bisphosphonates, furosemide, or calcitonin. Calcimemetic therapy (Cinacalcet) was effective but had to be discontinued due to GI intolerance. She requested a second opinion at our center after being referred for palliative radiation therapy for presumed inoperable disease. On presentation, she remained symptomatic with bone and joint pain, diffuse abdominal pain and fatigue. Repeat technetium-99m sestamibi (Tc-99m sestamibi) scintigraphy showed a faint area of uptake near the right clavicular head, adjacent to the site of her previous resections. With the intraoperative guidance of a hand-held gamma probe, a 2 cm recurrent parathyroid carcinoma was located and successfully excised. Intraoperative PTH levels confirmed surgical cure of this previously undetected foci of disease. The use of radioguidance and intraoperative PTH monitoring were the keys to a successful resection, and our patient remains disease free with 17 months of follow-up.
Abstract C58: The transglutaminase 2 (TG2) as a new target of p53
Authors: Shi Yun Yeo
Journal: Cancer Research (2013)

Abstract The transglutaminase type 2 (TG2) is a multifunctional protein that has been found previously to be upregulated in lung and breast cancer cells in response to DNA damage. Since the tumor suppressor p53 stabilizes and accumulates in the nucleus upon DNA damage, we investigated the relationship of TG2 and p53 in this study. We demonstrated that TG2 is a downstream target of p53. Knockdown of p53 down-regulated the expression of TG2 mRNA and protein. Similarly, over-expression of p53 upregulated the level of TG2 under normal cell culture condition and also with doxorubicin treatment. More importantly, we found that loss of TG2 enables the transformation of primary mammary epithelial cells in a sensitized colony forming assay. In this system, we used primary human mammary epithelial cells (HMECs) that over-express hTERT, SV40 Small T and RasV12; these cells depend only on the loss of p53 activity for full transformation. Interestingly, we observed a synergy in colony formation when both p21 and TG2 were knock-down, and this effect is even more pronounced when there is a deprivation of growth factors. We discovered that insulin and EGF can overcome the effects of p53 in colony formation and the combined loss of TG2 and p21 can replace the absence of insulin in the transformation of HMECs, similar to that of p53 knock-down. This suggests that loss of TG2 potentiates insulin signaling that could be important in cell transformation. Indeed, we showed that loss of TG2 increase the phosphorylation of 4EBP1 at Thr37/46. Our findings indicate that TG2 functions like a tumor suppressor and is an important target of p53. The loss of TG2 results in cell transformation by mimicking insulin signaling. Citation Format: Shi Yun Yeo. The transglutaminase 2 (TG2) as a new target of p53. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr C58.
Malignant Melanoma in Infancy
Authors: David Lyall
Journal: JAMA (1967)

<h3>To the Editor:—</h3> A 12-month-old boy was admitted to University Hospital on June 28, 1965, after an axillary biopsy performed elsewhere one week previously. He had been born with a raised pigmented lesion on the tip of the middle finger of the right hand. This had grown slowly, and at age 6 months surgical removal had been recommended. For one reason or another this had not been done, until the appearance of an enlarged axillary node about ten days before admission demanded attention. <h3>Physical Examination:—</h3> A purplishblack, raised lesion with a roughened surface invading the nail bed of the right middle finger and measuring 1.3× 0.6×9.5 cm (Fig 1) was revealed. No satellite nodules were present. On the medial aspect of the right axilla was a recently made biopsy incision 4-cm long, with the sutures still in place. Underlying postoperative induration was present but it was felt that there were