tbuckley/cabot-search huggingface dataset:
Demonstration of Peritoneo-Scrotal Communication by Tc-99m MAA Scintigraphy Following False-Negative Contrast CT
Authors: Grace Yung, Chuong Bui, Diep Nguyen, Lily Shen, Robert Mansberg
Journal: Clinical Nuclear Medicine (2010)

A 69-year-old man with end stage renal failure was on peritoneal dialysis for 5 months. He developed sudden onset of scrotal swelling after lifting and presented for investigation. Clinically he had bilateral scrotal swelling with findings suggestive of hydrocele. There was no evidence of hernia, peripheral, or dependent edema. CT of the pelvis with peritoneal contrast was performed, and contrast was seen in the dependent areas of the peritoneal cavity but not in the scrotum. Subsequently Tc-99m MAA peritoneal scintigraphy was performed which demonstrated diffuse tracer activity in the scrotum by 4 hours and persisted to 24 hours.
Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides
Authors: Yaarit Adamovich, Liat Rousso-Noori, Ziv Zwighaft, Adi Neufeld-Cohen, Marina Golik, Judith Kraut-Cohen, Miao Wang, Xianlin Han, Gad Asher
Journal: Cell Metabolism (2014)
Adrenalectomy as Palliative Treatment
Authors: Charles B. Huggins
Journal: JAMA (1967)

It is certain that removal of both adrenal glands of patients with widely disseminated mammary carcinoma can result in prompt, profound, and longlasting regression of the cancer. Consequently, bilateral adrenalectomy can be useful therapy in cancer. Regression of mammary cancer following removal of glands that produce growth-promoting steroids (ovary, testis, adrenal) depends on (1) hormone dependence of the tumor and (2) hormone production by the host. Adrenalectomy has little or no beneficial effect in patients with hormone-independent cancer. The earliest indication that advanced cancer of any sort can be induced to regress was the beneficial effect of oophorectomy on mammary cancer in women discovered by Beatson.<sup>6,7</sup>But why does cancer of the breast sometimes thrive in women deprived of ovarian function by oophorectomy or the menopause? Many theoretical considerations<sup>8</sup>have enabled us to identify the adrenal glands as factors in sustaining the presence of mammary cancer in man.
Mastering Communication with Seriously Ill Patients: Balancing Honesty with Empathy and Hope
Authors: Neil Abramson
Journal: Annals of Internal Medicine (2009)

Medical Writings: Book Notes3 November 2009Mastering Communication with Seriously Ill Patients: Balancing Honesty with Empathy and HopeNeil Abramson, MDNeil Abramson, MDFrom Baptist Cancer Institute, Jacksonville, Florida.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-9-200911030-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Back A, Arnold R, Tulsky J. 168 pages. New York: Cambridge Univ Pr; 2009. $45.00. ISBN 9780521706186. Order at www.cambridge.org/us/.Field of medicine: Patient–physician communications, care of seriously ill patients, hematology and oncology, and death and dying.Format: Paperback.Audience: Clinicians, physician extenders, nurses, and medical students, as well as persons who communicate directly with patients, especially those with serious illnesses.Purpose: To define the specific communication tasks involved in talking with patients with life-threatening illnesses and their families.Content: The book presents a stepwise series of encounters between the physician and the patient, beginning with the initial consultation and ... Author, Article, and Disclosure InformationAffiliations: From Baptist Cancer Institute, Jacksonville, Florida. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 November 2009Volume 151, Issue 9Page: 676KeywordsEmotionsHealth careHematology and oncologyMedical education ePublished: 3 November 2009 Issue Published: 3 November 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
REPORT OF A CESAREAN SECTION.
Authors: JAMES W. ROWE
Journal: JAMA (1905)

<h3>Previous History.</h3> —The patient was 26 years of age and weighed 96 pounds before the uterine contents were removed. She asserted that, when 2 years old, she was very sick with a fever, after recovering from which she did not walk for over a year. She was perfectly normal at birth and grew until 5 years old; since then she has grown broader, but very little taller. <h3>Examination.</h3> —On examination the patient was found to be 41 inches in height. The head, face and neck were normal and the intelligence above the average. The trunk was small, but not especially deformed. From the spine of the seventh cervical vertebra to the tip of the coccyx measured 20½ inches. The extremities were markedly short, stumpy and deformed. The arm from the shoulder to the tip of the middle finger measured 14 inches. The legs were approximately 16 inches long. Pelvis: The
The Conservative Treatment of Appendiceal Peritonitis
Authors: Alton Ochsner
Journal: JAMA (1981)

I enjoyed reading Dr Foraker's article, "A Reluctant Surgeon at Sea," inThe Journal(1981;245:2302-2303). Obviously, Dr Foraker is an internist and I want to congratulate him on using excellent judgment in treating the patient with a ruptured appendix. Undoubtedly, he saved the man's life. I don't know whether Dr Foraker is familiar with the conservative treatment of appendiceal peritonitis, first advocated by my distinguished cousin, Dr A. J. Ochsner of Chicago, in the latter part of the last century. Antibiotics were not yet available and infections were controlled only by good surgical treatment and the patient's resistance. Everyone has agreed that acute appendicitis should be operated on as soon as the diagnosis is made, but Dr Ochsner made the important observation that when peritonitis occurred, it frequently took precedence over the acute appendicitis. He believed these cases were better treated conservatively, particularly if there was beginning localization, because of
Nifedipine for epilepsy? A pilot study
Authors: J. G Larkin, E. Butler, M. J Brodie
Journal: BMJ (1988)

Right carotid sheathLeft carotid sheath s- Goite_ ~~~~~~~~~~~~~~~~~C omputed tomograph of neck and upper thorax.was no histological'evi'dence that the igoitre was benign, though clinically cancer seemed to be unlikely.To our knowledge our patent is the first reported case of Homer's syndrome where there was histological proof of benign thyroid disease and where the condition resolved after surgery.We thank Mr H R Matthews of East Birmingham Hospital for permission to report this case.
Coronary Endothelial Vasomotor Function and Vascular Remodeling in Heart Transplant Recipients Randomized for Tacrolimus or Cyclosporine Immunosuppression
Authors: Paraskevi Petrakopoulou, Lydia Anthopoulou, Michael Muscholl, Volker Klauss, Wolfgang von Scheidt, Peter Überfuhr, Bruno M. Meiser, Bruno Reichart, Michael Weis
Journal: Journal of the American College of Cardiology (2006)
Longer Training for Radiographers
Authors: P. Jacobs
Journal: BMJ (1964)

when in fact most of these calls are quite genuine and are very frequently to see a feverish child who has become progressively more ill during the day, and about whom the parents are extremely worried.Under the present system of payment, of course, one resents these calls very much indeed.How differently would one feel about them if there were a special system of payment, over and above the present payment, and not deductible from the Pool, of one guinea for each new call made between the hours of 5 p.m. and 8 a.m.There must be very few doctors who do not have to do at least 500 such calls each year.Instead of grumbling about these extra calls after a hard day's work, one should ask why it is that we do not recognize these calls as inevitable, insist on being paid adequately for them, but not out of the Pool, and do them with a rather better grace than is per- haps possible at present.I think that one guinea would be a fair payment, and that it should certainly not be borne by the patient, but by the Health Service.I consider that the following would be a suitable form for claiming the fee of one guinea from the National Health Service:
There Is a Rainbow Behind Every Dark Cloud
Authors: W. F. Eich
Journal: JAMA (1981)

This is a book written mostly by children who have leukemia, cancer, or serious brain damage. I saw excerpts from it in a lay magazine (OK, I admit it,<i>Reader's Digest</i>) and immediately ordered a copy. There is very little text. For the most part the book consists of pictures drawn by the children, expressing various aspects of their illnesses. A few cartoons were done by a professional cartoonist; one gets the impression that he may have joined the group to help stimulate them as cartoonists. His drawings are all right for a grown-up's, but of course the children's drawings are more powerful. The text tells how the children used their art to think about their diseases, to express their wishes and fears, and to keep their hopes and dreams alive. This is a<i>very</i>worthwhile book for those who work with seriously sick children. Although I am both a
900 CAVEOLIN-2 Q130E GENE POLYMORPHISM IS HIGHLY ASSOCIATED WITH RESPONSE TO ANTIVIRAL THERAPY IN HEPATITIS C AND CLINICAL FEATURES OF HEPATIC STEATOSIS
Authors: D. Rubin, H. Vollbrecht, S. Roß, S. Nasser, R. Günther, P. Buggisch, H. Hinrichsen, A. Ruether, H. Ulf, I. Nitz, F. Doering, M. Nothnagel, S. Schreiber, U.R. Fölsch, J. Schrezenmeir
Journal: Journal of Hepatology (2009)
On the rails for Europe
Authors: I Robertson
Journal: BMJ (1994)

The prospect of the first trains running from Waterloo station to Paris and Brussels fills me with boyish glee, I confess. There is something about long train journeys across large continents which yields a sense of travel in the true sense of the word, an experience completely absent in the squalor of the average airport departure lounge. Having worked as a stoker of steam engines on the German Bundesbahn as a student may have something to do with my infatuation with European railways, but there is more to it than this.

Margaret Thatcher detested railways because they are communal forms of transport and impossible …
Continuous versus bilevel positive airway pressure for obstructive sleep apnea.
Authors: M K Reeves-Hoché, D W Hudgel, R Meck, R Witteman, A Ross, C W Zwillich
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Recent objective studies demonstrate relatively low hours of nightly use during nasal continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA). Patients frequently complain of dyspnea or discomfort during CPAP use, especially during expiration (against the continuous pressure), which may be a reason for the low hours of use. We hypothesized that with decreased expiratory pressure, hours of nightly use would increase. Therefore, we randomized 83 OSA patients to receive either continuous or bilevel positive airway pressure when expiratory pressure is lower. To document objectively the effective use of either therapy, we built and installed elapsed-time and mask pressure sensors in the patients' positive airway pressure units. A total of 62 patients were evaluable and followed for 1 yr. Of these, 26 received bilevel and 36 CPAP pressures. The machine timers measured accumulated "machine-on" time, and the mask pressure sensor recorded the total time in which the mask pressure was within 2 cm H2O of the effective pressure (pressure shown to eliminate 95% of the obstructive apneas during a full night of polysomnography). The mean machine timer hours of CPAP were 5.0 +/- 0.19 SEM and 4.9 +/- 0.23 SEM during bilevel therapy (p NS) over a 12-mo period. The pressures required during CPAP or bilevel therapy were not different between high and low hourly users. Effective use, the percentage of time that the machine was running and the prescribed pressure was being delivered, was 80% in CPAP and 82% in the bilevel users (p NS). Both groups had equal complaints with regard to mask discomfort, machine noise, and nasal stuffiness.(ABSTRACT TRUNCATED AT 250 WORDS)
Neuropsychological Processing Associated With Recovery From Depression After Stereotactic Subcaudate Tractotomy
Authors: Tim Dalgleish, Jenny Yiend, Jessica Bramham, John D. Teasdale, Alan D. Ogilvie, Gin Malhi, Robert Howard
Journal: American Journal of Psychiatry (2004)

The authors compared patients who underwent stereotactic subcaudate tractotomy for depression, who were still depressed or recovered from depression, to identify therapeutic mechanisms.Ten depressed and eight recovered psychosurgery patients, along with nine never-depressed subjects and nine who had recovered from depression with medication, completed the Iowa Gambling Task, a measure of decision making in the face of feedback. Psychosurgery patients also completed general neuropsychological testing.Recovered psychosurgery patients exhibited insensitivity to negative feedback on the Iowa Gambling Task compared to the other three groups. This difference between the groups remained when general neuropsychological performance was covaried out.These findings suggest acquired relative insensitivity to negative information as a specific mechanism mediating the antidepressant effect of stereotactic subcaudate tractotomy. Such insensitivity is not secondary to deficits in general neuropsychological functioning and is not a function of recovery from depression per se.
Transplacental hyponatraemia due to oxytocin.
Authors: R H Schwartz, R W Jones
Journal: BMJ (1978)

Primary Salmonella typhi meningitis in an adultMeningitis due to Salmonella typhi is rare and usually occurs as a complication during typhoid fever.We report a case of S typhi meningitis that occurred as a primary illness in an otherwise healthy adult. Case reportA 24-year-old woman dental surgeon gave a two-day history of fever, vomiting, and headache of acute onset, with no associated bowel symptoms.She had been in good health and had been vaccinated against typhoid two years previously.Her history was otherwise insignificant.Examination showed a febrile patient of average build.The cardiovascular and respiratory systems were clinically normal.The abdomen was soft, with no distension, tenderness, or hepatosplenomegaly.Although conscious and rational, the patient was listless and uninterested in her surroundings.Neck rigidity was severe, and Kernig's sign was positive.The rest of the neurological examina- tion, including funduscopy, gave normal results.The white cell count was 17-2 x 109/1(17 200/mm3), with 92 % neutrophils, 6 % lymphocytes, and 2 %0 monocytes.Results of urine analysis and serum
Survival after partial lung transplants is as good as after full lung transplants
Authors: S. Gottlieb
Journal: BMJ (2003)

Portions of lungs transplanted from living donors function as well in the recipient as whole lungs and should be considered as an option for people waiting for an organ.

Dr Michael Bowdish of the University of Southern California said that data collected at his transplantation centre supported the wider use of partial lungs from living donors.

Lung transplantations may involve two lungs, a single lung, or a lobe of a lung (the lungs are divided into lobes, three in the right lung and two on the left). Most of the lobe transplantations have been done in patients with cystic …
Use of a NOTES closure device for full-thickness suturing of a postoperative anastomotic esophageal leakage
Authors: J. Hampe, B. Schniewind, M. Both, A. Fritscher-Ravens
Journal: Endoscopy (2010)

Leakages at surgical anastomoses in the gastrointestinal tract represent a challenging clinical problem. Standard therapy entails conservative or surgical revision of the anastomotic area with high morbidity and mortality up to 30 %. None of the previous endoscopic approaches, which include stenting, endoscopic clip closure, and fibrin glue injection, are sufficiently established for routine clinical use. We report a case of a 68-year-old woman with a postoperative leakage and abscess at the esophagojejunostomy. The defect was closed with two anchor-lock sutures. The patient was able to resume oral food intake 5 days later and made a full recovery with endoscopically documented mucosal healing at the site of the anastomosis. In summary, endoscopic suturing may be a promising approach for the treatment of postoperative leaks that warrants further, controlled investigation.
Prognostic Significance of Predominant Histologic Pattern and Nuclear Grade in Resected Adenocarcinoma of the Lung: Potential Parameters for a Grading System
Authors: Jan H. von der Thüsen, Yuen S. Tham, Holly Pattenden, Alexandra Rice, Michael Dusmet, Eric Lim, Andrew G. Nicholson
Journal: Journal of Thoracic Oncology (2012)
Porphyria cutanea tarda during maintenance haemodialysis.
Authors: J Garcia Parrilla, R Ortega, M L Pena, J L Rodicio, R E de Salamanca, A Olmos, G H Elder
Journal: BMJ (1980)

and trismus.As an acute presentation is unexpected therefore, clinical assessment in this case was difficult.A diagnosis of salivary duct calculi should always be considered in children when there is submandibular swelling and the appearances are uncharacteristic of suppurating cervical nodes.In this way inappropriate exploration of the cervical swelling will be avoided.
THE DEVELOPMENT AND MALFORMATIONS OF THE GLANS AND PREPUCE
Authors: F. W. Jones
Journal: BMJ (1910)

THic BRInsf *137 I and right clavicle.The vault of the skull was very vascular, very soft, and removed with great ease by the saw.The dura mater was adherent at the vertex for about 2 in.on either side of the falx cerebri, and was removed with the skull-cap.The thickness of the calvarium for the most part was from i in. to ,7 in.; just behind the right frontal region it measured 1 in., aud in the occipital bone varied from t in.to',&in.Both
Delayed androgen treatment prolongs survival in murine lupus.
Authors: J R Roubinian, N Talal, J S Greenspan, J R Goodman, P K Siiteri
Journal: Journal of Clinical Investigation (1979)

Female NZB/NZW F1 mice were treated as adults with 5-alpha-dihydrotestosterone powder packed into subcutaneous implants. Two treatment protocols were followed: (a) 3-mo-old mice received 6 mg of androgen, and (b) 6-mo-old mice were castrated and given 12 mg of androgen. Sham females received empty implants. Mice were followed monthly for surival, for antibodies to DNA and polyadenylic acid, and for renal histopathology. The percent survival at 11 mo was 74% for mice treated at 3 mo, compared to 11% for the sham controls, and 100% for mice treated at 6 mo, compared to 20% for their sham controls. Androgen-treated mice had less immune complex glomerulonephritis as determined by immunofluorescent and electron microscopy. Surprisingly, treated mice had no significant sustained reduction in antibodies to DNA although they had reduced antibodies to polyadenylic acid. These results suggest that androgens can still prolong survival and reduce immune complex deposition even when treatment is delayed to an age when disease is relatively established. After delayed androgen treatment, mice survive despite the presence of high levels of IgG antibodies to DNA.
Late diversification in the clonal composition of human cytomegalovirus-specific CD8+ T cells following allogeneic hemopoietic stem cell transplantation
Authors: Maher K. Gandhi, Mark R. Wills, Georgina Okecha, Elizabeth K. Day, Ray Hicks, Robert E. Marcus, J. G. Patrick Sissons, Andrew J. Carmichael
Journal: Blood (2003)
RBRVS Gets an Eye Test
Authors: Jeffrey S. Tennant
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The Commentary by Dr Hsiao et al<sup>1</sup>in the April 1, 1992, issue that the resource-based relative value scale (RBRVS) is a fair and equitable way of paying physicians cannot be allowed to go unchallenged. The authors' assumptions that values for time of service, intensity of service, and overhead suffice to determine price of service do not withstand scientific scrutiny. A fair test of any hypothesis, including the RBRVS formula, is whether its conclusions are compatible with established fact. The Hsiao formula fails that test. Medicaid and health maintenance organizations (HMOs) both require providers of medical services to work at a discount. Any formula that fairly assigns prices for nondiscounted services, such as Medicare services, should come up with substantially higher fees than either Medicaid or HMOs offer. Yet many services are valued by Hsiao at below those discounted rates. See also p 3363. Perimetry and
Is Bone Marrow Examination in Small-Cell Lung Cancer Really Necessary?
Authors: BARBARA CAMPLING
Journal: Annals of Internal Medicine (1986)

Of 403 patients with small-cell lung cancer, we identified by aspiration, biopsy, or both 67 with bone marrow involvement and found the two procedures to be complementary in detecting marrow involvement. The mean surface area of the positive biopsy specimens was significantly greater than that of a randomly selected group of negative biopsy specimens, suggesting that the larger the specimen, the greater the chance of detecting tumour. Patients with marrow involvement had only a slightly worse prognosis compared with other patients who had extensive disease. Only 7 of the 403 patients (1.7%) had extensive disease based on marrow involvement alone. Because bone marrow examination rarely changes the stage of cancer in noninvasively assessed patients, and has no impact on the tolerance of chemotherapy and only a small effect on length of survival, we do not recommend this procedure in the routine staging of small-cell lung cancer.
PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity
Authors: S A Hartsink-Segers, J J Beaudoin, M W J Luijendijk, C Exalto, R Pieters, M L Den Boer
Journal: Leukemia (2014)

Both tumour suppressor and oncogenic functions have been ascribed to the atypical zeta isoform of protein kinase C (PKCζ), whereas its constitutively active form PKMζ is almost exclusively expressed in the brain where it has a role in long-term memory. Using primers unique for either isoform, we found that both PKCζ and PKMζ were expressed in a subset of paediatric acute lymphoblastic leukaemia (ALL) cases carrying a TCF3 (E2A) chromosomal rearrangement. Combined PKCζ and PKMζ (PKC/Mζ) protein as well as phosphorylation levels were elevated in ALL cases, especially TCF3-rearranged precursor B-ALL cases, compared with normal bone marrow (P<0.01). Furthermore, high PKC/Mζ expression in primary ALL cells was associated with increased sensitivity to 6-thioguanine and 6-mercaptopurine (P<0.01), thiopurines used in ALL treatment. PKCζ is believed to stabilize mismatch-repair protein MSH2, facilitating thiopurine responsiveness in T-ALL. However, PKC/Mζ knockdown in a TCF3-rearranged cell line model decreased MSH2 expression but did not induce thiopurine resistance, indicative that the link between high PKC/Mζ levels and thiopurine sensitivity in paediatric precursor B-ALL is not directly causal. Collectively, our data indicate that thiopurine treatment may be effective, especially in paediatric TCF3-rearranged ALL and other patients with a high expression of PKC/Mζ.