tbuckley/cabot-search huggingface dataset:
Relation between Headaches from Oral Contraceptives and Development of Endometrial Arterioles
Authors: E. C. G. Grant
Journal: BMJ (1968)

The incidence of headaches during the first year on oral cotraceptives corrleates closely with the incidence of well-developed arterioles in endometrial biopsy specimens. This relationship appears to depend on the ratio between progestogenic and oestrogenic components of the pill as well as the particular steroids. Therefore endometrial biopsies are useful for assessing the vascular response to an oral contraceptive and also provide a short cut to clinical evaluation of new formulations.
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1
Authors: Francis J. Mcmahon, Nirmala Akula, Thomas G. Schulze, Pierandrea Muglia, Federica Tozzi, Sevilla D. Detera-Wadleigh, C. J. M. Steele, René Breuer, Jana Strohmaier, Jens R. Wendland, Manuel Mattheisen, Thomas W. Mühleisen, Wolfgang Maier, Markus M. Nöthen, Sven Cichon, Anne Farmer, John B. Vincent, Florian Holsboer, Martin Preisig, Marcella Rietschel
Journal: Nature Genetics (2010)
ON ASSURING HEALTHY DENTINE OVER ENDANGERED DANGERED PULPS.
Authors: JACOB L. WILLIAMS
Journal: JAMA (1885)

Read in the Section on Oral and Dental Surgery of American Medical Association, May, 1884. In saying endangered pulps I mean cases where the pulps have but little of the natural covering of dentine in the depths of cavities, which covering is very apt to be more or less tainted by disease, that is by the agents that have produced caries. Let us look at the conditions here existing. There is acid with fermentive action, often in full sway, seeming at first sight to demand the most decided and effective neutralizing and corrective applications. But, just beyond lie some of the most highly and delicately organized tissues of the whole body; fibres, that if rudely set vibrating will be likely to continue or repeat their vibrations in a very serious way; tissue, which if inflamed, there is none more doubtful of survival; and we must remember that the life of
Interrelation between Oxygen Tension and Nitric Oxide in the Respiratory System
Authors: MASAHIKO TSUCHIYA, HIROFUMI TOKAI, YOSHIKI TAKEHARA, YOSHIKURA HARAGUCHI, AKIRA ASADA, KOZO UTSUMI, MASAYASU INOUE
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

To understand the relationship between oxygen tension and nitric oxide (NO) function, one animal and two human studies were designed. In the animal study, the effect of NO in inducing the relaxation of aortic specimens was significantly lower by 68% under 480 mm Hg of oxygen tension than under 28 mm Hg, indicating that oxygen tension has an important role in determining the biological effects of NO. In a clinical analysis with nonsmokers (n = 23), the alveolar-to-arterial difference for oxygen (a-aDo 2) was reciprocally correlated with exhaled NO concentrations (r = 0.53). Because NO concentration in the lower respiratory zone depends partly on the amount of inspirable NO originating in the upper airway, a well-ventilated area, requiring much perfusion, could receive greater amounts of NO than a poorly ventilated one. Thus, the reciprocal relation of a-aDo 2 with the concentration of exhaled NO is not necessarily incompatible with the effect of hypoxic pulmonary vasoconstriction in ventilation-to-perfusion (V ′a/Q ′ ) imbalance. In our third experiment, with nonsmokers (n = 21), pure oxygen inhalation during mechanical ventilation significantly decreased the concentration of exhaled NO and enhanced a-aDo 2, indicating a relationship between NO and oxygen similar to that observed in the animal experiment. These findings led us to conclude that a positive relation between exhaled NO and blood oxygenation efficiency exists in the respiratory system, and further, that oxygen might affect this relationship. Thus, the relative balance of NO and oxygen concentrations may be another factor for consideration in respiratory function.
Gold Therapy for Rheumatoid Arthritis
Authors: John M. McMahon
Journal: Annals of Internal Medicine (1992)

Letters15 July 1992Gold Therapy for Rheumatoid ArthritisJohn M. McMahon, MDJohn M. McMahon, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-2-169_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In the Annals editorial on treatment of rheumatoid arthritis (1), various studies were reviewed which concluded that gold therapy was both ineffective and effective.I was introduced to gold therapy while on the Arthritis Service of the Mayo Clinic in the late 1940s and used it for over 40 years, until I retired last August. I developed a healthy respect for the drug when one of my patients in 1951 developed the only serious reaction that I saw, namely stomatitis, hepatitis, and a severe exfoliative dermatitis on the third injection. This may have been a true allergic...References1. Pincus T and Wolfe F. Treatment of rheumatoid arthritis: challenges to traditional paradigms. Ann Intern Med. 1991;115:825-7. LinkGoogle Scholar2. Smith R, Peak W, Kron K, Hermann I, DelToro R, and Goldman M. Increasing the effectiveness of GOLD therapy in rheumatoid arthritis. JAMA. 1958;167:1197-1204. CrossrefMedlineGoogle Scholar1. Wolfe F and Hawley D. Remission in rheumatoid arthritis. J Rheumatol. 1985;12:245-52. MedlineGoogle Scholar2. Pincus T, Callahan L, Sale W, Brooks A, Payne L, and Vaughn W. Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis Rheum. 1984;27:864-72. CrossrefMedlineGoogle Scholar3. Hawley D and Wolfe F. Are the results of controlled clinical trials and observational studies of second line therapy in rheumatoid arthritis valid and generalizable as measures of rheumatoid arthritis outcome: analysis of 122 studies. J Rheumatol. 1991;18:1008-14. MedlineGoogle Scholar4. Wolfe F and Pincus T. Standard self-report questionnaires in routine clinical and research practice—an opportunity for patients and rheumatologists. J Rheumatol. 1991;18:643-6. MedlineGoogle Scholar5. Pincus T, Callahan L, Brooks R, Fuchs H, Olsen N, and Kaye J. Self-report questionnaire scores in rheumatoid arthritis compared with traditional physical, radiographic, and laboratory measures. Ann Intern Med. 1989;110:259-66. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John M. McMahon, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMetalsCorrection: Gold Therapy for Rheumatoid Arthritis 15 July 1992Volume 117, Issue 2Page: 169-170KeywordsArthritisDrugsHepatitis ARheumatoid arthritis ePublished: 1 December 2008 Issue Published: 15 July 1992 PDF downloadLoading ...
The Presentation by the CDC of Data on AIDS
Authors: C. A. Caceres
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Data from the Centers for Disease Control (CDC) have obscured meaningful information since the acquired immunodeficiency syndrome (AIDS) was first reported. Review of the CDC's statistical tables shows that up to 1986, these tables led physicians to the erroneous impression that only 17% of the AIDS patients were intravenous drug abusers. After some publicity (<i>The Wall Street Journal</i>, Oct 24, 1985, p 32), the CDC abruptly changed its reporting to acknowledge that the real incidence was 25.1%.<sup>1</sup>Unfortunately, the CDC still does not categorize the AIDS population according to the extent of abuse of oral immunosuppressive drugs, such as LSD, methylenedioxyamphetamine, and cocaine-which the CDC's own estimates suggest is as high as 75% in homosexual subsets. The presentation of data on AIDS by the CDC continues to be confusing. To illustrate: the CDC collects data on AIDS patients who have had sex with other AIDS patients, but
The in vitro adsorption of cytokines by polymer-pyrolysed carbon
Authors: Carol A. Howell, Susan R. Sandeman, Gary J. Phillips, Andrew W. Lloyd, J. Graham Davies, Sergey V. Mikhalovsky, Steve R. Tennison, Anthony P. Rawlinson, Oleksandr P. Kozynchenko, Hannah L.H. Owen, John D.S. Gaylor, Jennifer J. Rouse, James M. Courtney
Journal: Biomaterials (2006)
NONALCOHOLIC FATTY LIVER DISEASE IN SAUDI TYPE 2 DIABETIC SUBJECT ATTENDING A MEDICAL OUTPATIENT CLINIC
Authors: عبير كوثر
Journal: Diabetes Care (2003)

NAFLD is a very common asymptomatic liver condition that may progress to cirrhosis and hepatocellular
carcinoma, and a relation to the different components of the metabolic syndrome has
been found. In this review we highlight some of the epidemiological aspects of the two disorders
and discuss some of the possible mechanisms and questions to be answered concerning the risk
factors for the progression of this condition as well as the need for more studies to focus on possible
modalities of treatment
A simple procedure for measuring pharyngeal sensitivity: a contribution to the diagnosis of sleep apnoea
Authors: M Dematteis
Journal: Thorax (2005)

Patients with severe apnoea may have an impaired pharyngeal dilating reflex related to decreased pharyngeal sensitivity. The accuracy of a simple new procedure to measure pharyngeal sensitivity and to diagnose sleep disordered breathing (SDB) was investigated.Pharyngeal disappearance and appearance sensory perception thresholds were measured by delivering different airflow rates on the soft palate using an intraoral device in 17 controls and 50 patients suffering from SDB evaluated by overnight polygraphy. The procedure was performed before (baseline) and after three successive administrations of a topical anaesthetic to sensitise the pharyngeal sensory impairment. Pharyngeal sensitivity was then evaluated according to SDB severity. SDB was classified as mild, moderate or severe according to the relative proportion of obstructive apnoeas-hypopnoeas and the amount of desaturation.Patients had higher baseline disappearance and appearance sensory thresholds than controls (mean (SD) 0.62 (0.44) v 0.26 (0.06) l/min and 0.85 (0.40) v 0.40 (0.19) l/min, p<0.001, respectively). Such differences were enhanced by topical anaesthesia. Impairment of pharyngeal sensitivity and the number of patients with impaired sensitivity increased from the least to the most severe SDB group as indicated by the test sensitivity for a respiratory disturbance index of >20/hour (50%, 73.7% and 88.5% in the mild, moderate, and severely affected groups, respectively).This simple and safe procedure showed that impairment of pharyngeal sensitivity is correlated with severity of SDB. Using this test in routine clinical practice may simplify the diagnosis of sleep apnoea, particularly for the most severe patients.
Improve clinical effectiveness, says DoH
Authors: A Tonks
Journal: BMJ (1994)

In a new year initiative to curb NHS spending on medical treatments that are unproved or don't work the NHS Management Executive is urging fundholding general practitioners and health authorities to consider the effectiveness of a treatment before buying it. Purchasers should, says the management executive, use clinical guidelines on good practice drawn up by doctors to help them contract for services that are known to be effective.

In a letter to all fundholders, trusts, and health authorities Dr Graham Winyard, health care director of the NHS Management Executive, and Mrs Yvonne Moores, director of …
Primary Cutaneous Small/Medium CD4<sup>+</sup> T-Cell Lymphomas: A Heterogeneous Group of Tumors With Different Clinicopathologic Features and Outcome
Authors: Adriana Garcia-Herrera, Luis Colomo, Mireia Camós, Joaquín Carreras, Olga Balague, Antonio Martinez, Armando Lopéz-Guillermo, Teresa Estrach, Elias Campo
Journal: Journal of Clinical Oncology (2008)

To define the clinical and pathologic characteristics of primary cutaneous small/medium CD4(+) T-cell lymphoma (PCSM-TCL) and identify parameters of prognostic significance.We have investigated 24 patients with primary cutaneous lymphomas composed of small/medium mature T-cells with a betaF1, CD3, CD4(+) and/or noncytotoxic, CD8(-) and CD30(-) phenotype. The proliferation index and CD8(+) infiltrating cells were quantified with an automated image analysis system.Sixteen patients presenting with solitary or localized plaques or small nodules (< 3 cm) had an indolent course. Only three patients experienced repeated cutaneous relapses, and none of them died as a result of the disease after 1 to 168 months (median, 17 months) of follow-up. The tumors had a low proliferation (median Ki-67, 9% +/- 5%) and an intense infiltrate of reactive CD8(+) (median, 20% +/- 11.7%). Five patients presenting with rapidly evolving large tumors or nodules (>/= 5 cm) had an aggressive disease and died with extracutaneous dissemination 18 to 36 months after diagnosis (median, 23 months). These tumors had a significantly higher proliferation (median Ki-67, 22% +/- 11.3%; P < .05) and lower number of infiltrating CD8(+) (median, 1% +/- 3%; P < .05) than the previous group. A third group of three patients had a peculiar clinical presentation with multifocal relapsing lesions without extracutaneous dissemination after a long period of follow-up ranging from 41 to 92 months. Histologically, these cases had an intense infiltrate of eosinophils.PCSM-TCL is a heterogeneous group of tumors with differentiated clinical and pathological characteristics with impact in the outcome of the patients.
LEFT VENTRICULAR DIMENSIONS DERIVED BY ECHOCARDIOGRAPHY CORRELATE WITH BODY MASS INDEX IN A LARGE POPULATION OF MULTIETHNIC ATHLETES SCREENED IN THE TEXAS ADOLESCENT ATHLETE HEART SCREENING REGISTRY (TAAHSR)
Authors: Silvana M. Lawrence, Harold W. Kohl, Patrick W. Austin, Kim A. Frost, Jennifer Y. Hutchings, Arnold Fenrich, Eva M. Garcia, James Guerrero, George P. Rodgers
Journal: Journal of the American College of Cardiology (2012)
Acute Gastroduodenal Disease after Thermal Injury
Authors: Albert J. Czaja, Joseph C. McAlhany, Basil A. Pruitt
Journal: New England Journal of Medicine (1974)

To determine the incidence and the natural history of acute gastroduodenal disease after thermal injury, early and serial gastroduodenoscopies were performed in 32 adult patients with burns. Gastric erosions were present in 25 of 29 (86 per cent) with large burns. Seventeen of 23 (74 per cent) had lesions within 72 hours after the burn. In seven patients (22 per cent) a gastric ulcer developed. Ulcerations occurred only in diffusely abnormal areas and were not discovered before 72 hours after the burn. Nine patients (28 per cent) had a duodenal ulceration; all but one had concomitant gastric disease. In two cases, an ulcer was observed to evolve from an erosive "duodenitis." The early development, morphology and histology of the lesions suggested ischemic damage of the mucosa. Nine of 15 patients studied serially had progression of mucosal disease; sepsis, hypotension and hypoxia complicated the clinical course. Life-threatening hemorrhage or perforation occurred mainly in patients with ulcers (eight of nine cases). (N Engl J Med 291:925–929, 1974)
Body Ritual among the Nacirema
Authors: Paul A. M. Gross
Journal: New England Journal of Medicine (1959)

CLYDE Kluckhohn, an anthropologist with a sharp eye for cultural common denominators, has pointed out that man is distinguished from other living organisms by three characteristics of human activity: the systematic making of tools; the use of abstract language; and religion. Religion is a broad term, embodying not only belief in a supernatural power but also an elaborate web of myth, theology and ritual. Even Communist Russia and China, perhaps the first human societies to deny collectively the need of religion or belief in the supernatural, have a highly complex ceremony and ritual in their party structure, and the Marxist . . .
Ramipril and Risk of Diabetes
Authors: A. H. Shlossberg
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New rules announced on confidentiality of US patient records
Authors: D. Josefson
Journal: BMJ (2002)

The Bush administration has released its controversial rules governing federal protection for the medical privacy of patients in the United States.

The new rules are more lenient than privacy regulations proposed under the Clinton administration,and some feel they do not go far enough in guaranteeing the protection of patients.

The regulations seek to balance patient privacy protection against the routine sharing of medical information between healthcare providers and payers. They take effect on 14 April 2003. They will apply to health …
Treatment for osteoarthritis thrown into question
Authors: D. Spurgeon
Journal: BMJ (2002)

Patients receiving arthroscopic lavage or debridement for osteoarthritis of the knee in a controlled trial reported no better pain relief than patients who received only skin incisions without the actual surgery.

The randomised, placebo controlled trial to evaluate the efficacy of arthroscopy for osteoarthritis was conducted with 180 patients by researchers from the US Department of Veterans Affairs, Baylor College of Medicine and International Survey Research, both in Houston, and Laguna Honda Hospital, San Francisco ( New England Journal of Medicine 2002;347:81-8). Both real and placebo surgeries were performed by Dr Bruce Moseley, a clinical associate professor of orthopaedics at Baylor College. Ethical issues were critically assessed by Dr Baruch Brody, …
Dietary Factors and Schizophrenia
Authors: SEYMOUR S. KETY
Journal: Annals of Internal Medicine (1976)

Editorials1 June 1976Dietary Factors and SchizophreniaSEYMOUR S. KETY, M.D.SEYMOUR S. KETY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-6-745 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the beginning of this century a substantial fraction of patients in mental hospitals were suffering from pellagrous dementia. With the discoveries that this disorder resulted from a specific dietary deficiency, correctable by means of nicotinic acid, it practically disappeared. Where it still exists, it exists because of failure to apply the knowledge we have. Following that example, there have been numerous attempts to implicate dietary factors in other mental illnesses. In the past decade, two hypotheses have been proposed relating schizophrenia to diet. In 1968, Pauling (1) pointed out the likelihood that there is a much wider variance in...References1. PAULING L: Orthomolecular psychiatry. Science 160:265-271, 1968 CrossrefMedlineGoogle Scholar2. DOHAN F: Cereals and schizophrenia: data and hypothesis. Acta Psychiatr Scand 42:125-152, 1966 CrossrefMedlineGoogle Scholar3. DEANHANNIFFYSTEVENS GLF: Schizophrenia and coeliac disease. J Irish Med Assoc 68:545-546, 1975 Google Scholar4. DOHANGRASBERGERLOWELL FJF: Relapsed schizophrenics: more rapid improvement on a milk- and cereal- free diet. Br J Psychiatry 115:595-596, 1969 CrossrefMedlineGoogle Scholar5. SINGHKAY MS: Wheat gluten as a pathogenic factor in schizophrenia. Science 191:401-402, 1976 CrossrefMedlineGoogle Scholar6. WALSH D: Coeliac disease and schizophrenia. Br Med J 2:242, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harvard University and Psychiatric Research Laboratories Massachusetts General Hospital Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySchizophrenia: is the potato the environmental culprit?Vitamin C status in chronic schizophreniaSeasonal variations in psychiatric illnessGenetics and schizophrenic behaviorFood AllergySchizophrenia and coeliac disease – the nature of the relationship 1 June 1976Volume 84, Issue 6Page: 745-745KeywordsDementiaDietNiacinSchizophrenia Issue Published: 1 June 1976 PDF downloadLoading ...
Urticarial vasculitis with shock, leukopenia and thrombocytopenia, possibly due to anaphylatoxin release
Authors: G. GUILLET, R. JEUNE
Journal: British Journal of Dermatology (1983)

Journal Article Urticarial vasculitis with shock, leukopenia and thrombocytopenia, possibly due to anaphylatoxin release Get access G. GUILLET, G. GUILLET Centre Hospitalier Universitaire, Service de Dermatologie (Pr. Texier), 33000 Bordeaux, France G. Guillet, M.D., Hopital des Enfants, 168 couse de l'Argorme, 33077 Bordeaux‐Cedex, France. Search for other works by this author on: Oxford Academic Google Scholar R. JEUNE R. JEUNE Centre Hospitalier de Valence, 26000 Valence, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 5, 1 May 1983, Pages 605–608, https://doi.org/10.1111/j.1365-2133.1983.tb01064.x Published: 01 May 1983 Article history Accepted: 01 September 1982 Published: 01 May 1983