tbuckley/cabot-search huggingface dataset:
Comparative Validation of Quantitative Coronary Angiography Systems
Authors: David Keane, Jürgen Haase, Cornelis J. Slager, Eline Montauban van Swijndregt, Kenneth G. Lehmann, Yukio Ozaki, Carlo di Mario, Richard Kirkeeide, Patrick W. Serruys
Journal: Circulation (1995)

Background Computerized quantitative coronary angiography (QCA) has fundamentally altered our approach to the assessment of coronary interventional techniques and strategies aimed at the prevention of recurrence and progression of stenosis. It is essential, therefore, that the performance of QCA systems, upon which much of our scientific understanding has become integrally dependent, is evaluated in an objective and uniform manner. Methods and Results We validated 10 QCA systems at core laboratories in North America and Europe. Cine films were made of phantom stenoses of known diameter (0.5 to 1.9 mm) under four experimental conditions: in vivo (coronary arteries of pigs) calibrated at the isocenter or by use of the catheter as a scaling device and in vitro with 50% contrast and 100% contrast. The cine films were analyzed by each automated QCA system without observer interaction. Accuracy and precision were taken as the mean and SD of the signed differences between the phantom stenoses, and the measured minimal luminal diameters and the correlation coefficient ( r ), the SEE, the y intercept, and the slope were derived by their linear regression. Performance of the 10 QCA systems ranged widely: accuracy, +0.07 to +0.31 mm; precision, ±0.14 to ±0.24 mm; correlation ( r ), .96 to .89; SEE, ±0.11 to ±0.16 mm; intercept, +0.08 to +0.31 mm; and slope, 0.86 to 0.64. Conclusions There is a marked variability in performance between systems when assessed over the range of 0.5 to 1.9 mm. The range of accuracy, intercept, and slope values of this report indicates that absolute measurements of luminal diameter from different multicenter angiographic trials may not be directly comparable and additionally suggests that such absolute measurements may not be directly applicable to clinical practice using an on-line QCA system with a different edge detection algorithm. Power calculations and study design of angiographic trials should be adjusted for the precision of the QCA system used to avoid the risk of failing to detect small differences in patient populations. This study may guide the fine-tuning of algorithms incorporated within each system and facilitate the maintenance of high standards of QCA for scientific studies.
Remarkable improvement of chronic hepatitis B following simultaneous administration of interferon and short term prednisone therapy
Authors: X. Causse, H. Godinot, F. Zbulim, P. Chossegros, T. Fontanges, J.P. Zarski, C. Meschievitz, J. Albrecht, C. Trépo
Journal: Journal of Hepatology (1990)
The Death of House Officers
Authors: Chi-yuan Hsu
Journal: Annals of Internal Medicine (1999)

Letters5 January 1999The Death of House OfficersChi-yuan Hsu, MDChi-yuan Hsu, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Fitzgerald (1) sounds like she stepped straight out of the book House of God(2). Does she honestly believe that a stressful internship does not increase the risk for suicide in someone who is depressed? In blaming the suicide on faulty neurotransmitters, Dr. Fitzgerald is trying to administer a large dose of denial to herself and to the medical community.References1. Fitzgerald F, Murray TJ. On the death of house officers. Ann Intern Med. 1998;128:949-50. LinkGoogle Scholar2. Shen S. House of God. New York: Dell Books; 1981. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOn the Death of House Officers Faith Fitzgerald and T. Jock Murray The Death of House Officers Andrew Naidech The Death of House Officers Faith T. Fitzgerald Metrics 5 January 1999Volume 130, Issue 1Page: 81KeywordsNeurotransmittersSuicide Issue Published: 5 January 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Women's magazines damage women's health
Authors: Des Spence
Journal: BMJ (2012)

On holiday in the sun, you download books to your Kindle that you know you’ll never read, take lots of clothes but wear only one pair of shorts, check your email even though you vowed you wouldn’t, sloppily apply sun cream so you look like a tartan blanket the next day, and still listen to the Today programme. The children still fight; same stress, different country. And you end up reading not your short history of modern China but the magazines someone left in the apartment.⇑

These have half dressed bleached blonde women in bikinis on …
The medical student as behavioural psychotherapist.
Authors: R S Stern
Journal: BMJ (1975)

A group of medical students were randomly selected from a larger group to carry out behaviour therapy under supervision. Ten patients with phobic disorders and two with obsessive-compulsive neurosis were treated, and the results, assessed by ratings of proved reliability, compared favourably with other studies in which psychiatrists or nurses acted as therapists. A questionnaire survey showed that students involved in therapy had a more favourable opinion about this kind of treatment than those receiving only theoretical instruction. The results suggested not only that medical students make good behavioural psychotherapists but also that the subject is a worthwhile training experience which warrants inclusion in the curriculum.
FDG PET/CT Findings in a Case of Myositis Ossificans Circumscripta of the Forearm
Authors: Frédéric Clarençon, Frédérique Larousserie, Antoine Babinet, Christophe Zylbersztein, Jean-Noël Talbot, Khaldoun Kerrou
Journal: Clinical Nuclear Medicine (2010)

Myositis ossificans circumscripta (MOC) is a rare benign neoplasm located in soft tissues that, most of the time, appears after a local trauma. The positive diagnosis of MOC may be challenging on CT or MRI findings. We report on an atypical case of a spontaneous nontraumatic MOC in a 54-year-old man, located in the longus supinatus muscle diagnosed with MRI and F-18 FDG PET/CT findings. Rarely described F-18 FDG PET/CT features in MOC are presented. Pattern of avid FDG focus on PET/CT, that may wrongly suggest osteosarcoma, is presented.
DEFLECTION OF THE NASAL SEPTUM AND ITS SURGICAL TREATMENT.Read in the Section on Laryngology and Otology, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: E. A. SPILSBURY
Journal: JAMA (1894)

Deflections of the septum, either as a result of traumatism or inflammatory action, are probably the most frequent of the exciting causes of catarrhal inflammation in the nasal mucous membrane. Consequently, it becomes a matter of considerable importance that we should thoroughly appreciate, not only their method of development, but also the nature of their action upon the lining membrane of the nasal cavities, as well as their influence upon its respiratory functions. In health, we find the nasal septum presenting simply as a bony and cartilaginous wall, dividing the nasal passages into two symmetrical cavities. In diseased conditions, we find present in this structure certain abnormalities of contour, which undoubtedly have a marked influence in the production of an ordinary catarrhal inflammation. The earliest investigators attributed deflections to excessive growth of the septum, as a result of which it became too large to fit in its bony framework, thereby
Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats
Authors: Cecilia Grappone, Massimo Pinzani, Maurizio Parola, Giulia Pellegrini, Alessandra Caligiuri, Raffaella DeFranco, Fabio Marra, Hermann Herbst, Gianfranco Alpini, Stefano Milani
Journal: Journal of Hepatology (1999)
PITYRIASIS VERSICOLOR WITH SUBSEQUENT LEUCODERMIC PATCHES
Authors: H. G. ADAMSON
Journal: British Journal of Dermatology (1949)

Journal Article PITYRIASIS VERSICOLOR WITH SUBSEQUENT LEUCODERMIC PATCHES Get access H. G. ADAMSON H. G. ADAMSON Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 61, Issue 10, 1 October 1949, Pages 322–323, https://doi.org/10.1111/j.1365-2133.1949.tb11037.x Published: 01 October 1949
Liver Herniation Through the Foramen of Morgagni
Authors: William Makis, Christopher Rush
Journal: Clinical Nuclear Medicine (2011)

Diaphragmatic hernias are characterized by defects in the diaphragm that allow herniation of abdominal contents into the thorax. Herniation through the retrosternal foramen of Morgagni is rare, with less than 300 adult cases reported in the literature. This is a case of a 90-year-old woman who was diagnosed with herniation of the liver through the foramen of Morgagni on F-18 FDG PET/CT scan, which was done for the evaluation of a lung mass. Herniation of liver through the foramen of Morgagni is a potential pitfall in oncologic F-18 FDG PET/CT imaging, as it may mimic any FDG-avid anterior mediastinal mass, benign or malignant, especially in the presence of significant respiratory artifacts that commonly degrade image quality at the lung bases.
Risk and Predictors for Pregnancy-Related Complications in Women With Heart Disease
Authors: Samuel C. Siu SM, Mathew Sermer, David A. Harrison, Elizabeth Grigoriadis, Grace Liu, Sheryll Sorensen, Jeffrey F. Smallhorn BS, Dan Farine, Kofi S. Amankwah, John C. Spears, Jack M. Colman
Journal: Circulation (1997)

Background The physiological changes of pregnancy can result in cardiovascular complications in the mother, which in turn may have fetal implications. Prior studies have focused on specific cardiac lesions or identified univariate predictors. There is a need to refine the risk stratification of women with heart disease so they can receive appropriate obstetrical counseling and care. Methods and Results We examined the outcomes of 221 women with heart disease who underwent 276 pregnancies and received their obstetrical care at three Toronto hospitals from 1986 through 1994. Those who underwent therapeutic abortions were excluded. Among the study participants, there were 24 miscarriages and 252 completed pregnancies (pregnancies not ending in miscarriage). Maternal heart failure, arrhythmia, or stroke occurred in 45 completed pregnancies (18%). There were no maternal deaths. Poor maternal functional class or cyanosis, myocardial dysfunction, left heart obstruction, prior arrhythmia, and prior cardiac events were predictive of maternal cardiac complications. These predictors were incorporated into a point score that can be used to estimate the probability of a cardiac complication in the mother. The rate of cardiac complications for a patient with 0, 1, and &gt;1 of the above factors was 3%, 30%, and 66%, respectively. Neonatal complications occurred in 42 completed pregnancies (17%). Neonatal events included death (2), respiratory distress syndrome (16), intraventricular hemorrhage (2), premature birth (35), and small-for-gestational-age birth weight (14). Poor maternal functional class or cyanosis was predictive of neonatal events. Conclusions Despite low maternal and neonatal mortality, pregnancy in women with heart disease is associated with significant cardiac and neonatal morbidity. The probability of maternal cardiac or neonatal events can be predicted from baseline characteristics of the mother.
Drug Trapping in Intravenous Infusion Side Arms
Authors: Anita Johnston-Early
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Bolus injection of drugs into the Y-side arm of a freely running intravenous (IV) line is a common method for administration of cancer chemotherapy. In two patients treated in this manner, a heavy precipitate was noted in the IV tubing. Both patients complained of transient dyspnea. Investigation revealed that the Y-side arm of the tubing acted as a reservoir for injected drugs. Precipitation resulted when a second incompatible drug was injected through the same Y-side arm. In our patients, the possible drugs implicated were methotrexate (25 mg/mL, preservative free or preserved with 0.9% benzyl alcohol), dorperidol (2.5 mg/mL), and furosemide (10 mg/mL). In vitro, we found that droperidol produced a heavy precipitate when mixed with preservativefree methotrexate or furosemide and a very fine precipitate with methotrexate in benzyl alcohol. Methotrexate and furosemide did not precipitate together. A fine precipitate can be difficult to see in IV tubing.
Development and evaluation of novel biodegradable microspheres based on poly(d,l-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies
Authors: Raghavendra C. Mundargi, S. Srirangarajan, Sunil A. Agnihotri, Sangamesh A. Patil, S. Ravindra, Swati B. Setty, Tejraj M. Aminabhavi
Journal: Journal of Controlled Release (2007)
Recent Accreditation Council for Graduate Medical Education Initiatives Have Not Been Shown to Improve the Education of Cardiology Fellows
Authors: Thomas M. Bashore, Andrew Wang
Journal: Circulation (2008)

The best lad schemes o' mice an' men Gang aft agley, An' lea'e us nought but grief an' pain, For promis'd joy! -Robert BurnsThe "Best Lad Scheme" Before formal training programs in medicine, physician trainees learned at the feet of established physicians.Although formal training programs in internal medicine and surgery had been around for many years, the Flexner report in 1910 fundamentally changed how training was performed. 1,2lexner described the mediocre quality of medical education at the turn of the century, noting the poor facilities, the profit motives, and the inadequate curricula.To reform medical education, he envisioned academically oriented hospitals where clinical observations drove research questions and advancements in patient care.Postgraduate trainees were indeed "residents"; they lived at the hospital, allowing the closest observation of their patients and a continuity of inpatient care that was unmatched.Indeed, in this setting, a night off duty was characterized, without a lack of sarcasm, as a lost opportunity to learn.
Cost-Effectiveness of Detecting and Treating Diabetic Retinopathy
Authors: Mark Lambert
Journal: Annals of Internal Medicine (1996)

Letters1 December 1996Cost-Effectiveness of Detecting and Treating Diabetic RetinopathyMark Lambert, MB, BSMark Lambert, MB, BSUniversity of York, Heslington, York YO1 5DD, United Kingdom.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-11-199612010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The carefully conducted and clear cost–utility analysis by Javitt and Aiello [1] provides useful information on the economics of diabetic retinal screening for different populations from the perspective of a health insurance agency. There are, however, two major limitations to the application of the study findings to decision making.The valuation of sight considers two levels of outcome, depending on whether the affected person is well or poorly adjusted to his or her disability. The proportion of patients reaching these end points is estimated from national figures on the outcome of rehabilitation. This estimate assumes that blind ...REFERENCE1. Javitt JC, Aiello LP. Cost-effectiveness of detecting and treating diabetic retinopathy. 1996; 124(1 pt 2):164-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of York, Heslington, York YO1 5DD, United Kingdom. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRifabutin: where do we stand in 2016? 1 December 1996Volume 125, Issue 11Page: 939KeywordsDecision makingDiabetic retinopathyDisabilitiesEye diseasesHealth careHealth economicsHealth insurancePopulation statisticsQuality of lifeTouch Issue Published: 1 December 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response
Authors: Liang Xie, Xinchun Pi, Ashutosh Mishra, Guohua Fong, Junmin Peng, Cam Patterson
Journal: Journal of Clinical Investigation (2012)

The DNA damage response (DDR) is a complex regulatory network that is critical for maintaining genome integrity. Posttranslational modifications are widely used to ensure strict spatiotemporal control of signal flow, but how the DDR responds to environmental cues, such as changes in ambient oxygen tension, remains poorly understood. We found that an essential component of the ATR/CHK1 signaling pathway, the human homolog of the Caenorhabditis elegans biological clock protein CLK-2 (HCLK2), associated with and was hydroxylated by prolyl hydroxylase domain protein 3 (PHD3). HCLK2 hydroxylation was necessary for its interaction with ATR and the subsequent activation of ATR/CHK1/p53. Inhibiting PHD3, either with the pan-hydroxylase inhibitor dimethyloxaloylglycine (DMOG) or through hypoxia, prevented activation of the ATR/CHK1/p53 pathway and decreased apoptosis induced by DNA damage. Consistent with these observations, we found that mice lacking PHD3 were resistant to the effects of ionizing radiation and had decreased thymic apoptosis, a biomarker of genomic integrity. Our identification of HCLK2 as a substrate of PHD3 reveals the mechanism through which hypoxia inhibits the DDR, suggesting hydroxylation of HCLK2 is a potential therapeutic target for regulating the ATR/CHK1/p53 pathway.
Reinventing the wheel, square
Authors: A. J. Jenkins
Journal: BMJ (2010)

Perry and colleagues analysed the cases of 1999 patients to try to formulate “a clinical decision rule to rule out subarachnoid haemorrhage” in patients presenting to emergency departments.1

Neurosurgeons—the clinicians ultimately dealing with the condition—have an extremely low threshold for investigating patients for subarachnoid haemorrhage. We will investigate, …
Informed consent: the intricacies
Authors: R. Smith
Journal: BMJ (1997)

hould the BMJ reject all studies that do not include informed consent?That's a simple question, and surely the answer should be equally simple-"Yes."Unfortunately, ethical questions rarely allow simple answers, and we want help with answering this one.This issue includes a cluster of material that relates to the question.We publish the materialincluding two studies in which informed consent was not sought-to encourage debate and to arrive at a deeper understanding if not a simple answer.Medical journals must consider the ethical aspects of all the material they publish, and medical editors are presented with ethical issues just as often as doctors-that is, every day.
Sober Reflections on Imprisonment of Alcoholics
Authors: John T. Flynn
Journal: JAMA (1966)

To the Editor:—  I would like to offer some sober reflection on your editorial Recent Court Decisions Regarding Imprisonment of Alcoholics ( 197 :582, 1966).  The hospital with which I am associated is located a few short blocks from Wall Street, the world's wealthiest financial district, and a few blocks from the Bowery, the world's most famous skid row. I am unaware of any insurmountable social and administrative barriers to the medical care here of alcoholics from any stratum of financial or social life, yet astonishingly few alcoholics ask for medical help. The reasons are simple. The employed alcoholic is fearful that his employer by accident might learn of the reason for his admission. The skid row alcoholic has entirely different reasons.  The Bowery is a community of lost souls, lost without each other. When advised that admission is necessary for truly medical reasons, the Bowery inhabitant is more likely to
THE SELECTION OF HARD CLINICAL ENDPOINTS VERSUS SURROGATE ENDPOINTS AS THE PRIMARY OUTCOME MEASURE IN MAJOR CARDIOVASCULAR CLINICAL TRIALS IS NOT INFLUENCED BY THE SOURCE OF FUNDING
Authors: Ashish Aneja, Ricardo Esquitin, Kshitij Shah, Louai Razzouk, Rupa Iyengar, Irfan Wali, Verghese Mathew, Michael E. Farkouh
Journal: Journal of the American College of Cardiology (2010)
Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands
Authors: CARMEN C.-W.YU, M.G. COOK
Journal: British Journal of Dermatology (1990)

A retrospective study was made of the histopathology of axillary skin excised from 12 patients with hidradenitis suppurativa. In the majority of cases (10 out of 12), squamous epithelium-lined structures, in the form of cysts or sinuses were identified in the dermis. Laminated keratin was present in all these structures and half of the cysts also contained hair shafts, suggesting that they are derived from hair follicles. Only a small proportion of cases (4 out of 12) displayed inflammation in apocrine glands, and in these the inflammation was also seen around eccrine glands, hair follicles and the epithelium-lined structures. However, in cases where the epithelium of the 'cysts' was disrupted, the inflammatory infiltrate appeared to be centred around these areas. These observations suggest that the squamous epithelium-lined structures, which probably represent abnormal dilated hair follicles, are a more constant diagnostic feature in hidradenitis suppurativa than inflammation of apocrine glands which appears to be a secondary phenomenon.
Treating of Anorectal Gonorrhea
Authors: Hans H. Neumann
Journal: JAMA (1980)

To the Editor.—  The article by Michael Sands, MD, MPH (243:1143, 1980), describes the failure rate with different regimens in treating anorectal gonorrhea. We saw failures with 2 g of spectinomycin hydrochloride and with standard doses of tetracyclines, but not with 4 g of spectinomycin hydrochloride. In treating anorectal infections with orally given tetracyclines, we supplement these effectively with tetracycline hydrochloride suppositories. The extent of these infections is anatomically limited. Patients receive four 125-mg suppositories and are told to insert them once a day. The tetracycline suppositories are not available from pharmaceutical manufacturers and have to be prepared by a local pharmacist. We have not tried to find the minimum effective number of suppositories nor their preventive value for homosexual men.
At year's end, what's new with interferon?
Authors: William A. Check
Journal: JAMA (1979)

Last year the American Cancer Society (ACS) announced that it was spending $2 million to purchase 40 billion units of interferon from the Finnish Red Cross, enough for American oncologists to study interferon's anticancer activity in about 150 patients. This expenditure, the largest on a single project in the society's history, was prompted by preliminary results from the United States and Sweden showing that interferon can halt or reverse the growth of osteogenic sarcoma, melanoma, breast cancer, and lymphoma in some patients. One misconception about this trial was recently discussed by Thomas Merigan, MD, of Stanford University, a codirector of the study. "Because of the expense and publicity associated with this clinical trial," he explained, "people think there will be quick answers." But, in his view, this is only the first of many clinical trials that will be needed to establish whether interferon is a useful antitumor agent. For this