tbuckley/cabot-search huggingface dataset:
Tang® and Methadone by Vein
Authors: ROBERT C. WOLFE
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 May 1972Tang® and Methadone by VeinROBERT C. WOLFE, M.D., MARCUS M. REIDENBERG, M.D., F.A.C.P., VICENTE DINOSO, M.D.ROBERT C. WOLFE, M.D.Search for more papers by this author, MARCUS M. REIDENBERG, M.D., F.A.C.P.Search for more papers by this author, VICENTE DINOSO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-830_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently methadone has been increasingly employed as the mainstay of programs designed to control heroin addiction. Methadone itself is now emerging as a drug of abuse (1). Individual doses of methadone are frequently dispensed to the addict patient in a drink called Tang® (General Foods Corp.). Although intended to be drunk, the mixture has been injected intravenously by addicts (2). We have seen a patient who developed medical complications after a series of such injections.A 29-year-old white man was admitted to the Clinical Research Center on 27 September 1971 because of weakness and joint pain after... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT C. WOLFE, M.D.; MARCUS M. REIDENBERG, M.D., F.A.C.P.; VICENTE DINOSO, M.D.Affiliations: Temple University School of Medicine Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTrauma and Substance Abuse: Deadly Consequences of Intravenous Percocet TabletsNA Musculoskeletal Syndrome in Intravenous Heroin Users Association with Brown HeroinROBERT S. PASTAN, M.D., STUART L. SILVERMAN, M.D., DON L. GOLDENBERG, M.D.Perspectives in Drug Abuse 1 May 1972Volume 76, Issue 5 Page: 830-830 Keywords Addicts Arthralgia Drug abuse Drugs Food Heroin Opioid addiction Veins ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Response to Open Peer Commentaries on “Addressing Dual Agency: Getting Specific About the Expectations of Professionalism”
Authors: Jon C. Tilburt
Journal: The American Journal of Bioethics (2014)

"Response to Open Peer Commentaries on “Addressing Dual Agency: Getting Specific About the Expectations of Professionalism”." The American Journal of Bioethics, 14(10), pp. W4–W5
Is Altruism a Vice?
Authors: John R. Dykers
Journal: JAMA (1988)

To the Editor. —  I write concerning the letter by Dr Adams 1 on the editorial by Dr Pellegrino 2 and on the letter by Dr Tiemstra and the reply by Dr Pellegrino. 3 Dr Adams will be hard-pressed to find classical backing for his definition of altruism either by Comte or by John Stuart Mill. Neither placed great value on self-sacrifice as an end in itself. Only when self-sacrifice produced a greater good for greater numbers of persons was it a value. The positivist school would reject Dr Adams' conclusions as immature and naive.
The Changes in the Circulation After Birth
Authors: ABRAHAM M. RUDOLPH
Journal: Circulation (1970)

Circulatory changes at birth have a profound influence on the physiology of the circulation in normal infants and those with congenital heart disease. Since the concept that cardiac defects are fixed entities is being superseded by an appreciation of the changing nature of physiologic disturbances and their clinical consequence, the course and distribution of the fetal circulation with the influences of the major changes at birth, including changes in pulmonary vascular resistance, and closure of the ductus arteriosus and foramen ovale, require study. This lecture traces these and other changes and discusses their influences on congenital heart disease.
Kerry-Jane Hogg
Authors: F. Dunn, M. McEntegart
Journal: BMJ (2011)

The death of Dr Kerry-Jane Hogg at the age of 51 has robbed Scotland of one of its outstanding cardiologists. Dr Hogg, who was a consultant cardiologist at Stobhill Hospital and Golden Jubilee National Hospital and honorary senior lecturer at the University of Glasgow, was born in Kilmun and educated at Dunoon Grammar, from where she won a bursary to study medicine at the University of Glasgow. She graduated in 1982 with commendation and the Marion Gilchrist prize for most distinguished female graduate in the year.

Her postgraduate training was at Stobhill Hospital, where her undoubted talents were quickly recognised with early promotion to the post of research fellow and honorary registrar. She combined academic excellence with an impressive work ethic. She undertook key studies in thrombolysis, which formed the basis of her MD thesis and a number of key publications, including first authorship of a paper in the Lancet . She also attained an MSc in clinical pharmacology.

She was appointed consultant cardiologist …
Pharmacological studies of anthralin erythema
Authors: KLAUS MISCH, MICHAEL DAVIES, MALCOLM GREAVES, ANGELA COUTTS
Journal: British Journal of Dermatology (1981)

Journal Article Pharmacological studies of anthralin erythema Get access KLAUS MISCH, KLAUS MISCH Institute of Dermatology, Homerton Grove, London Search for other works by this author on: Oxford Academic Google Scholar MICHAEL DAVIES, MICHAEL DAVIES Plymouth General Hospital, Greenbank, Plymouth, Devon Search for other works by this author on: Oxford Academic Google Scholar MALCOLM GREAVES, MALCOLM GREAVES Institute of Dermatology, Homerton Grove, London Search for other works by this author on: Oxford Academic Google Scholar ANGELA COUTTS ANGELA COUTTS Institute of Dermatology, Homerton Grove, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s20, 1 August 1981, Pages 82–86, https://doi.org/10.1111/j.1365-2133.1981.tb01017.x Published: 01 August 1981
Left Ventricular Activation Time in Normal Men
Authors: TAKASHI WADA
Journal: Circulation (1959)

Simultaneous recordings from right and left precordial leads in 50 normal individuals were obtained. The duration of rS in lead V 1 , was always equal to or greater than the duration of qR in lead V 7 . Evidence is presented to support the thesis that the duration of rS in lead V 1 , is a more accurate index of left ventricular activation time than the duration of qR in the left precordial leads.
Depression and CD4 Decline-Reply
Authors: Constantine G. Lyketsos
Journal: JAMA (1994)

<h3>In Reply.</h3> —We found depressive symptoms did not affect time to acquired immunodeficiency syndrome (AIDS) or time to death in HIV-infected homosexual men as did our San Francisco colleagues.<sup>1</sup>In their present letter, Dr Barrett and colleagues assert we failed to observe, as they did, an effect of depression on CD4 decline because our participants had low baseline CD4 cell counts. We replicated their analysis splitting our cohort around the median baseline CD4 cell count reported in their letter (0.621×10<sup>9</sup>/L). Using this dichotomization, the "higher" baseline CD4 group had a mean baseline CD4 cell count of 0.870×10<sup>9</sup>/L. Mean annual CD4 decline was -0.068×10<sup>9</sup>/L for the 104 depressed respondents vs -0.072×10<sup>9</sup>/L for the 422 nondepressed subjects in this group (<i>P</i>=.57). The "lower" baseline CD4 group had a mean baseline CD4 cell count of 0.434×10<sup>9</sup>/L. The mean annual CD4 decline
Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
Authors: Hitoshi Takizawa, Satoshi Nishimura, Naoya Takayama, Atsushi Oda, Hidekazu Nishikii, Yohei Morita, Sei Kakinuma, Satoshi Yamazaki, Satoshi Okamura, Noriko Tamura, Shinya Goto, Akira Sawaguchi, Ichiro Manabe, Kiyoshi Takatsu, Hiromitsu Nakauchi, Satoshi Takaki, Koji Eto
Journal: Journal of Clinical Investigation (2009)

The nature of the in vivo cellular events underlying thrombus formation mediated by platelet activation remains unclear because of the absence of a modality for analysis. Lymphocyte adaptor protein (Lnk; also known as Sh2b3) is an adaptor protein that inhibits thrombopoietin-mediated signaling, and as a result, megakaryocyte and platelet counts are elevated in Lnk-/- mice. Here we describe an unanticipated role for Lnk in stabilizing thrombus formation and clarify the activities of Lnk in platelets transduced through integrin alphaIIbbeta3-mediated outside-in signaling. We equalized platelet counts in wild-type and Lnk-/- mice by using genetic depletion of Lnk and BM transplantation. Using FeCl3- or laser-induced injury and in vivo imaging that enabled observation of single platelet behavior and the multiple steps in thrombus formation, we determined that Lnk is an essential contributor to the stabilization of developing thrombi within vessels. Lnk-/- platelets exhibited a reduced ability to fully spread on fibrinogen and mediate clot retraction, reduced tyrosine phosphorylation of the beta3 integrin subunit, and reduced binding of Fyn to integrin alphaIIbbeta3. These results provide new insight into the mechanism of alphaIIbbeta3-based outside-in signaling, which appears to be coordinated in platelets by Lnk, Fyn, and integrins. Outside-in signaling modulators could represent new therapeutic targets for the prevention of cardiovascular events.
Aphrodisiacs: The Science and the Myth
Authors: Domeena C. Renshaw
Journal: JAMA (1986)

From the Department of Pharmacology of England's University of Bristol comes this scientific, smallprint, 276-page, nonsensational review of the ever-interesting topic of aphrodisiacs. A delightful appendix lists animal, vegetable, and mineral substances regarded through the centuries as capable of arousing sexual desire and assisting potency: almonds, anchovy, ants, apples, beans, beef, blood, camel bone, carrots, castor oil, celery, champagne, chocolate, cinnamon, frog's legs, lizards, lobsters, mussels, mustard, vanilla, vitamins, yeast, yogurt, and yohimbine are but a few on the long and ancient list, plus, of course, alcohol of every variety. Surprisingly, shark fins and elephant hooves, so popular in the Far East and Africa, were omitted, while rhinoceros horn is discussed in the body of the book but is not on the list. There is no sensationalism, but rather a scholarly approach, a readable concise style, and a chapter-by-chapter review of the literature with a bibliography for each segment. Unfortunately,
Improving Selection Criteria for Early Cystectomy in High-Grade T1 Bladder Cancer: A Meta-Analysis of 15,215 Patients
Authors: William Martin-Doyle, Jeffrey J. Leow, Anna Orsola, Steven L. Chang, Joaquim Bellmunt
Journal: Journal of Clinical Oncology (2015)

High-grade T1 (HGT1) bladder cancer is the highest risk subtype of non-muscle-invasive bladder cancer, with highly variable prognosis, poorly understood risk factors, and considerable debate about the role of early cystectomy. We aimed to address these questions through a meta-analysis of outcomes and prognostic factors.PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and American Society of Clinical Oncology abstracts were searched for cohort studies in HGT1. We pooled data on recurrence, progression, and cancer-specific survival from 73 studies.Five-year rates of recurrence, progression, and cancer-specific survival were 42% (95% CI, 39% to 45%), 21% (95% CI, 18% to 23%), and 87% (95% CI, 85% to 89%), respectively (56 studies, n = 15,215). In the prognostic factor meta-analysis (33 studies, n = 8,880), the highest impact risk factor was depth of invasion (T1b/c) into lamina propria (progression: hazard ratio [HR], 3.34; P < .001; cancer-specific survival: HR, 2.02; P = .001). Several other previously proposed factors also predicted progression and cancer-specific survival (lymphovascular invasion, associated carcinoma in situ, nonuse of bacillus Calmette-Guérin, tumor size > 3 cm, and older age; HRs for progression between 1.32 and 2.88, P ≤ .002; HRs for cancer-specific survival between 1.28 and 2.08, P ≤ .02).In this large analysis of outcomes and prognostic factors in HGT1 bladder cancer, deep lamina propria invasion had the largest negative impact, and other previously proposed prognostic factors were also confirmed. These factors should be used for prognostication and patient stratification in future clinical trials, and depth of invasion should be considered for inclusion in TNM staging criteria. This meta-analysis can also help define selection criteria for early cystectomy in HGT1 bladder cancer, particularly for patients with deep lamina propria invasion combined with other risk factors.
718 Neutrophil myeloperoxidase and oxidized phosphatidylcholine in non-alcoholic fatty liver disease: a potential source of oxidative stress in steatotic livers
Authors: Y IKURA, M OHSAWA, E HAI, S KAYO, N YOSHIMI, N SHIRAI, Y SUGAMA, H FUJINO, T INOUE, H JOMURA
Journal: Hepatology (2003)
MicroRNA-133 controls cardiac hypertrophy
Authors: Alessandra Carè, Daniele Catalucci, Federica Felicetti, Désirée Bonci, Antonio Addario, Paolo Gallo, Marie-Louise Bang, Patrizia Segnalini, Yusu Gu, Nancy D Dalton, Leonardo Elia, Michael V G Latronico, Morten Høydal, Camillo Autore, Matteo A Russo, Gerald W Dorn, Øyvind Ellingsen, Pilar Ruiz-Lozano, Kirk L Peterson, Carlo M Croce, Cesare Peschle, Gianluigi Condorelli
Journal: Nature Medicine (2007)
Does digitalis influence the response to beta-blockade in patients with severe chronic heart failure? Results of the COPERNICUS study
Authors: Alan B. Miller, Christopher O'Connor, Andrew J. Coats, Henry Krum, Michal Tendera, Paul Mohasci, Jean L. Rouleau, Michael B. Fowler, Hugo A. Katus, Ellen B. Roecker, Milton Packer
Journal: Journal of the American College of Cardiology (2002)
Conditional switching: a new variety of regression with many potential environmental applications.
Authors: M E Tarter, M D Lock, R M Ray
Journal: Environmental Health Perspectives (1995)

We introduce a new form of regression that has many applications to environmental studies. For a sequence composed of key variates with prototypic value chi, this form differs from the estimation of a location parameter-based curve, mu(chi), a scale parameter-based curve, sigma(chi), or other currently used types of regression. Instead of estimating a curve location, scale, or alpha-quantile parameter, it assumes that there are two or more population subgroups; for example, consisting of unsensitized and sensitized individuals, respectively. Although within each subgroup the relationships mu(chi) or sigma(chi) may or may not be horizontal, these relationships are not deemed to be of primary importance. Instead, the mixing parameter P that indexes the proportions of the two subgroups is treated as being related to the key variate value chi. In the sense that its goal is the estimation of a proportion, the new procedure resembles logit regression. But, in terms of the continuous spectrum of values attained by the response variate, the means used to attain its goal are dissimilar from those of logit regression. Specifically, group membership is not known directly but is determined from a proxy continuous variate whose values overlap between groups. Examples are given with simulated and natural data where this new form of regression is applied. We believe that conditional switching regression is a particularly valuable research tool when chemical level chi of an induced asthma attack or birthweight chi measured in a study of the biomarker cotinine's effect on pregnancy outcomes determines whether an attack or a negative outcome occurs.(ABSTRACT TRUNCATED AT 250 WORDS)
AN INVESTIGATION INTO THE EFFECT OF CYTOCHROME P450 (CYP) 2D6 GENOTYPE ON PHARMACOKINETICS, PHARMACODYNAMICS AND OUTCOMES DURING METOPROLOL CR/XL THERAPY IN A HEART FAILURE COHORT: A MERIT-HF SUB-STUDY
Authors: Jonathan Adam Batty, Anthony Balmforth, Hazel L. White, John Wikstrand, Rudolf De Boer, Dirk van Veldhuisen, Pim van der Harst, Ake Hjalmarson, John Kjekshus, Alistair Hall
Journal: Journal of the American College of Cardiology (2013)
Within-Family Environmental Transmission of Drug Abuse
Authors: Kenneth S. Kendler, Henrik Ohlsson, Kristina Sundquist, Jan Sundquist
Journal: JAMA Psychiatry (2012)

CONTEXT Drug abuse (DA) strongly runs in families. Does this result solely from genetic factors or does the family environment contribute? OBJECTIVE To determine the familial environmental contribution to the risk for DA. DESIGN Follow-up in 9 public databases (1961-2009) in siblings and spouses. SETTING Sweden. PARTICIPANTS A total of 137 199 sibling pairs and 7561 spousal pairs containing a proband with DA and matched control probands. MAIN OUTCOME MEASURES Drug abuse recorded in medical, legal, or pharmacy registry records. RESULTS In the best-fit model, which contained significant linear, quadratic, and cubic effects, among full sibling pairs containing a proband with DA, the relative risk for DA in the sibling declined from more than 6.0 for siblings born within 2 years of each other to less than 4.5 when born 10 years apart. Controlling for age differences in full sibling pairs, the hazard rate for DA in a sibling when the affected proband was older vs younger was 1.42 (95% CI, 1.31-1.54). In the best-fit model, which contained significant linear, quadratic, and cubic effects, among spousal pairs containing a proband with DA, the relative risk for DA in the spouse declined from more than 25.0 within 1 year of proband DA registration to 6.0 after 5 years. CONCLUSIONS Controlling for genetic effects by examining only full siblings, sibling resemblance for the risk for DA was significantly greater in pairs closer vs more distant in age. Older siblings more strongly transmitted the risk for DA to their younger siblings than vice versa. After one spouse is registered for DA, the other spouse has a large short-lived increase in DA risk. These results support strong familial environmental influences on DA at various life stages. A complete understanding of the familial transmission of DA will require knowledge of how genetic and familial environmental risk factors act and interact over development.
Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
Authors: Carolyn S Lee, Aparna Bhaduri, Angela Mah, Whitney L Johnson, Alexander Ungewickell, Cody J Aros, Christie B Nguyen, Eon J Rios, Zurab Siprashvili, Aaron Straight, Jinah Kim, Sumaira Z Aasi, Paul A Khavari
Journal: Nature Genetics (2014)
Walkie-talkie evolution: Bipedalism and vocal production
Authors: Robert R. Provine
Journal: Behavioral and Brain Sciences (2004)

A converging pattern of evidence from laughter, tickling, and motherese suggests that bipedal locomotion plays a critical and unanticipated role in vocal evolution. Bipedalism frees the thorax of its support role during quadrupedal locomotion, which permits the uncoupling of breathing and striding necessary for the subsequent selection for vocal virtuosity and speech.
Normal Immune Response to Hepatitis B Vaccine in Patients With Down's Syndrome
Authors: Catherine L. Troisi, Dorothy A. Heiberg, F. Blaine Hollinger
Journal: JAMA (1985)

Institutionalized patients with Down's syndrome (DS) are uniquely predisposed to develop chronic hepatitis B infection following exposure. Therefore vaccination is particularly warranted, but there have been concerns that these individuals may react suboptimally. We examined the immune responses of 62 institutionalized patients with DS to 20 and 40 micrograms of hepatitis B vaccine inactivated (Heptavax-B) over one year. The subjects were matched by weight, age, and sex. Seroconversion rates and levels of antibodies to hepatitis B surface antigen (anti-HBs) were comparable to those found in a normal population and were higher than those found in immunocompromised patients undergoing hemodialysis. The anti-HBs levels were consistently higher in the 40-micrograms vaccine group. In patients with DS who were over 30 years old, age was a significant factor in predicting anti-HBs responses. Conversely, in younger subjects, weight was negatively correlated with anti-HBs levels. These data clearly indicate that patients with DS respond normally to hepatitis B surface antigen vaccination and need not be considered a special group when guidelines for vaccination are recommended.
Influence of haematological indices on combat athletic groups in Nigeria
Authors: Venkateshwarlu Kankanala, Igah J Ameh, Ezra A Gunen
Journal: British Journal of Sports Medicine (2010)

Alterations in different haematological indices have been shown to affect both health and performance. These alterations seem to be influenced by demographic factors as sex and age. However, the influence of sex on the haematological indices of judo karate and taekwondo athletic groups has not been established in Nigeria. The purpose of this study was therefore to find out differences among judo, karate and taekwondo athletic groups in their haematological indices and influence of sex on these indices. To achieve the purpose of this study 15 male and 15 female subjects were randomly drawn from each of judo, karate and taekwondo athletic group (45 males and 45 females). They were tested for haemoglobin (HB), haematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), serum ion, total iron binding capacity, percent transferrin saturation, serum ferritin, creatine kinase (CK) and glycosylated haemoglobin status (GHS). The results of this study show that judo groups had higher MCV (86.14 ± 0.18%) and MCHC (28.64 ± 0.49%), while karate group has higher mean serum ion (115.74 ± 2.31 mg/dl), whereas the taekwondo group has a higher mean HB (15.42 ± 0.37 g/dl), mean HCT (45.88 ± 1.22%), total ion binding capacity (366.11 ± 7.84 mg/dl), serum ferritin (1.65 ± 0.05 mg/dl), CK (100.25 ± 2.86 U) and GHS (5.63 ± 0.28%). The results further revealed that male judo group had higher mean values for most of the haematological indices as was the case with male karate and taekwondo athletes. However, female judo group has higher MCV and MCHC while female taekwondo group had higher mean CK values compared with their male counterparts.
Soluble CD30 in pediatric patients with atopic dermatitis
Authors: A. Frezzolini, M. Paradisi, M. Ruffelli, S. Cadoni, O. De Pità
Journal: Allergy (1997)

Atopic dermatitis (AD) is a chronic, inflammatory skin disease in which a pathogenetic role of Th2 cells has been supposed. This study investigated the presence of soluble CD30 (sCD30), an activation marker of T-cell clones able to produce Th2-type cytokines, in sera from pediatric patients affected by AD (n = 25) with no symptoms of asthma or rhinitis. The severity of the disease was graded by both the SCORAD and Costa et al. clinical scoring systems. Serum levels of sCD30 were significantly higher in patients with AD in respect to both normal donors (n = 20) and urticaria patients (n = 10), and a positive correlation between serum sCD30 and clinical score was found (r = 0.508; P = 0.01) when AD patients were evaluated by Costa et al.'s method. Furthermore, a significant association (r = 0.443; P = 0.027) between sCD30 and serum levels of the soluble interleukin (IL)-2 receptor (sIL-2R) was observed in AD. The presence of high amounts of sCD30 in atopic patients seems to confirm the role of this molecule as an activation marker useful for in vivo evaluation of a Th2 immune response, and the correlation observed with both clinical score and sIL-2R levels indicates the role of sCD30 as an additional marker of disease activity in pediatric patients with AD.
Mesenteric Venous Thrombosis
Authors: Shaji Kumar, Michael G. Sarr, Patrick S. Kamath
Journal: New England Journal of Medicine (2001)

Mesenteric venous thrombosis usually involves the superior mesenteric vein, with the danger of bowel infarction. The newer imaging techniques allow earlier diagnosis. A predisposing condition (such as a prothrombotic state, pancreatitis, and recent abdominal surgery) can be identified in most patients. Treatment involves anticoagulation, and surgery may be avoided if the correct diagnosis is made early.