Experimental Studies of Portal-systemic Collateral Circulation
Authors: JESSE L. BOLLMAN
Journal: Annals of Internal Medicine (1964)

Article1 September 1964Experimental Studies of Portal-systemic Collateral CirculationJESSE L. BOLLMAN, M.D.JESSE L. BOLLMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-3-402 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPortal-systemic collateral circulation develops gradually after any occurrence that gives rise to increased pressure in the portal vein. Cirrhosis of the liver giving rise to increased resistance to the passage of blood through the hepatic sinusoids is the most frequent cause. Similarly, any factor compromising the outflow of blood from the hepatic veins will cause the development of a portal-systemic collateral circulation, as will direct encroachment on the portal vein. Except for hemorrhage from gastroesophageal varices, no great harm seems to be done by the diversion of portal blood to collateral channels and the systemic circulation. Animals will withstand complete...References1. BOLLMANFLOCKGRINDLAYBICKFORDLICHTENHELD JLEVJHRGFR: Coma with increased amino acids of brain and cerebrospinal fluid in dogs with Eck's fistula: prevention by portal-systemic collateral circulation. Arch. Surg. (Chicago) 75: 405, 1957. Google Scholar2. ECK NV: K. voprosu o perevyazkie vorotnois veni. Predvaritelnoye soobshtshjenye. Voennomed. Zh. 130: 1, 1877. Google Scholar3. HAHNMASSENNENCKIPAWLOW MOMJ: Die Eck'sche Fistel zwischen der unteren Hohlvene und der Pfortader und ihre Folgen für den Organismus. Arch. Exp. Path. Pharm. 32: 161, 1893. CrossrefGoogle Scholar4. SHERLOCKSUMMERSKILLWHITEPHEAR SWHLPEA: Portal-systemic encephalopathy: neurological complications of liver disease. Lancet 2: 453, 1954. CrossrefGoogle Scholar5. BOLLMAN JL: The animal with an Eck fistula. Physiol. Rev. 41: 607, 1961. CrossrefGoogle Scholar6. FREEMAN S: Effect of Eck fistula formation, simple portal obstruction and 'meat intoxication' on serum phosphatase and dye clearance of adult dogs. Amer. J. Physiol. 159: 351, 1949. CrossrefMedlineGoogle Scholar7. SVECFREEMAN MHS: Effect of impaired hepatic circulation on plasma free amino acids of dogs. Ibid., p. 357. Google Scholar8. MANNBOLLMANHUIZENGAFARRARGRINDLAY JDJLKATJH: Blood ammonia, experimental and clinical study in abnormalities of the liver and portal circulation. Gastroenterology 27: 399, 1954. CrossrefMedlineGoogle Scholar9. RIDDELLKOPPLEPHYLLISMCDERMOTT AGNWV: The etiology of "meat intoxication" in the Eck fistula dog. Surgery 36: 675, 1954. MedlineGoogle Scholar10. DRAPANASBECKERSCHENCKSHAWPOTTERSTEWART TDRWGWWWHJD: Ammonia intoxication from portal diversion and hepatic failure. Ann. Surg. 142: 560, 1955. CrossrefMedlineGoogle Scholar11. BOLLMANMANN JLFC: The physiology of the impaired liver. Ergebn. Physiol. 38: 445, 1936. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, MinnesotaFrom the Mayo Clinic and Mayo Foundation, Rochester, Minnesota.This paper was presented as the John Phillips Memorial Lecture at the Forty-fifth Annual Session of the American College of Physicians at Atlantic City, New Jersey, on April 7, 1964.Requests for reprints should be addressed to Jesse L. Bollman, M.D., Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAuxiliary liver-graft without portal blood. Experimental autotransplantation of left liver lobesEffect of portal ligation and of Eck's fistula on hepatic blood flow and concentration of blood ammoniaClinical Aspects of the Hepatic Circulation 1 September 1964Volume 61, Issue 3Page: 402-410KeywordsBloodCirrhosisFistulasGastroenterology and hepatologyHemorrhageLiverPortal veinsRespirationVeins Issue Published: 1 September 1964 PDF downloadLoading ...