tbuckley/cabot-search huggingface dataset:
Angiotensin II and Stretch Activate NADPH Oxidase to Destabilize Cardiac Kv4.3 Channel mRNA
Authors: Chaoming Zhou, Chandra Ziegler, Lori A. Birder, Alexandre F.R. Stewart, Edwin S. Levitan
Journal: Circulation Research (2006)

Pathological and physiological hypertrophy of the heart is associated with decreased expression of the Kv4.3 transient outward current (Ito) channel. The downregulation of channel mRNA and protein, which may be proarrhythmic, is recapitulated with cultured neonatal rat ventricular myocytes treated with angiotensin II (Ang II). Here we show that the 4.9 kb 3' untranslated region (3' UTR) of the Kv4.3 channel transcript confers Ang II sensitivity to a promoter-reporter construct. In contrast, Kv4.2 and Kv1.5 3'-UTR sequences are insensitive to Ang II. Both Kv4.3 3'-UTR reporter mRNA and activity are decreased in Ang II-treated cardiac myocytes, in accordance with a decrease in mRNA stability. This regulation is mediated by Ang II type 1 (AT1) receptors and abolished by NADPH oxidase inhibitors and dominant negative rac. The Ang II effect is also blocked by expression of superoxide dismutase (SOD), but not catalase, showing that superoxide is required. Dominant negative subunits, enzyme inhibitors and hydrogen peroxide experiments show that the apoptosis signal-regulating kinase 1 (ASK1)-p38 kinase pathway mediates downstream signaling from NADPH oxidase. Mechanical stretch also downregulates Kv4.3 3'-UTR reporter activity and this requires AT1 receptors and NADPH oxidase. Thus, activation of AT1 receptors by Ang II or stretch specifically destabilizes cardiac myocyte Kv4.3 channel mRNA by activating NADPH oxidase. These results link long-term control of cardiac K+ channel gene expression to a physiological reactive oxygen species signaling pathway.
Screening, ethics, and the law.
Authors: N. Wald, M. Law
Journal: BMJ (1992)

operative complications and therefore the day-case unit is not a suitable place for basic surgical training.All trainees should, however, benefit from experience in the day-case unit."'With the high level of day surgery in the United States much of trainees' teaching there must obviously go on in that setting.One of us (RH) performs 40% of his cataract operations as day cases and finds no real difficulty in teaching junior staff members while so doing.We certainly agree with Alistair R Fielder that this issue must not be used to stem the development of day case cataract surgery.Colin Dryden may be correct in claiming that modern general anaesthesia has many of the benefits associated with local anaesthesia.2A recent study of cataract surgery comparing general anaes- thesia with local anaesthesia found, however, that local anaesthesia was 15 times cheaper in material, led to a faster throughput of patients in the operating theatre, and halved the expenditure on staff (ophthalmologists gave the local anaesthetic).'These are important factors where waiting lists are long or units are competing to obtain contracts for work.Patients' opinions are hard to gauge, but a small study of 24 patients with cataract suggested a preference for local anaesthesia.4
Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites
Authors: Clare M. Smith, Ante Jerkovic, Hervé Puy, Ingrid Winship, Jean-Charles Deybach, Laurent Gouya, Giel van Dooren, Christopher Dean Goodman, Angelika Sturm, Hana Manceau, Geoffrey Ian McFadden, Peter David, Odile Mercereau-Puijalon, Gaétan Burgio, Brendan J. McMorran, Simon J. Foote
Journal: Blood (2014)
THE EFFECT OF CROSS-REACTING ANTIGENS ON THE TOLERANT STATE
Authors: B. Cinader, J. E. M. St. Rose, M. Yoshimura
Journal: The Journal of Experimental Medicine (1967)

Rabbits were rendered tolerant to human albumin (HA) and were then injected with azo and oxazolonated derivatives of human albumin. These injections were continued to a time at which all animals would have lost tolerance if they had not been injected. Injection of cross-reacting antigens prolonged the duration of tolerance, as judged by the mode of elimination of lightly iodinated human albumin (HA.(131)I). Different derivatives of HA differed in their capacity to prolong tolerance. Those neonatally injected rabbits which were immunized with cross-reacting antigens and lost tolerance, responded much more promptly to HA.(131)I than animals which were not immunized. Animals immunized with cross-reacting antigen which went on to eliminate HA.(131)I triphasically, usually had responded earlier by making antibodies. These antibodies contained a fraction which was reactive with HA, and which was usually equally well adapted to determinants on HA and on the cross-reacting antigen.
Public health reforms won't mitigate the cuts
Authors: T. Blackman
Journal: BMJ (2011)

Among the places least resilient in coping with the Conservative led coalition government’s public spending cuts in England is the northern town of Middlesbrough, where 33% of jobs are in the public sector and 21% of the population of working age are claiming benefits because they are out of work. Previous Labour administrations used growth in public sector jobs to help tackle worklessness, bringing many women, in particular, into the workforce. Now women will bear the brunt of public sector job cuts. The scenario coincides with the latest life expectancy figures, which show a fall in female life expectancy in Middlesbrough.

How much will places like Middlesbrough be helped by this government’s reinvention of public health with its own separate budget and a new home in local authorities rather than the NHS? Certainly, this budgetary transparency contrasts with the last Labour period, when it was impossible to establish how much was being spent on public health and tackling health inequalities. The last Labour period was also a time of growing medicalisation in public health, when the race to hit …
A CASE OF MYCOTIC ANEURYSM OF THE GLUTEAL ARTERY
Authors: Julien E. Benjamin
Journal: JAMA (1924)

<h3>History.</h3> —H. B., a white woman, aged 24, a worker in a box factory, was admitted to the hospital, Sept. 13, 1923, because of pain in the right leg. It began suddenly, September 7, in the right gluteal region and upper portion of the right thigh. The pain was constant, but not severe in the beginning. It slowly descended the leg, and by September 10, was present throughout the entire right leg, from the region of the greater trochanter to the foot; in a general way, it followed the course of the great sciatic nerve. The pain on admission was severe enough to prevent the patient from resting or sleeping, and she was kept comfortable only by the aid of analgesics. The patient's father died of tuberculosis. The family history was otherwise of no importance. The patient had never been in robust health, and she had been in particularly
Abstract 3407: Regulation of c-Myc and p53 by splicing factor SRp20
Authors: Xiaolong He, Jilai Yang, Shijie Wang
Journal: Cancer Research (2014)

Abstract SRp20 is a member of the highly conserved SR protein family of splicing regulators. Our previous study found that SRp20 was overexpressed in ovarian and breast tumors compared to corresponding normal tissues and knockdown of SRp20 expression inhibited tumor cell growth. Suppression of SRp20 by 90% triggered apoptosis of tumor cells through intrinsic pathway, which was accompanied by a downregulation of anti-apoptotic protein, Bcl-2. However, it is unclear what mechanism mediates the induction of apoptosis and downregulation of Bcl-2 by SRp20 knockdown. To address this question, we conducted microarray analysis to identify the genes whose expression or splicing are altered in SRp20-knockdown A2780 cells. Among hundreds of identified genes, the expression of c-Myc and p53 was downregulated. The downregulation was further validated by quantitative PCR. Because of the fundamental importance of p53 and c-Myc in cancer biology and apoptosis, we further examined the expression of these two genes at protein levels. Western blotting showed that p53 is upregulated at protein level in SRp20 knockdown cells, contradictory to its expression at the mRNA level, while the expression of c-Myc is consistent at the protein level and at the mRNA level. These results suggest that SRp20 knockdown-induced apoptosis could be mediated by upregulated p53 protein or reduced c-Myc or both, given already established connection between these two proteins and apoptosis. How SRp20 is involved in the regulation of p53 and c-Myc remains to be determined and is currently under investigation. Citation Format: Xiaolong He, Jilai Yang, Shijie Wang. Regulation of c-Myc and p53 by splicing factor SRp20. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3407. doi:10.1158/1538-7445.AM2014-3407
Benefit and Cost Analysis in Geriatric Care
Authors: Jerry Avorn
Journal: New England Journal of Medicine (1984)

CONSIDERABLE enthusiasm has developed in recent years about the use of quantitative methods to guide the allocation of health-care resources. These approaches attempt to assign specific numerical values to the benefits of medical interventions of various kinds, as well as to their costs. Once quantified, costs and outcomes are then compared to indicate which health-care interventions make the most efficient use of available resources. Cost-benefit analysis reduces all factors to a common unit of measurement, generally dollars; cost-effectiveness analysis likewise expresses treatment costs in dollars, but leaves out-comes in terms more recognizable to the clinician—e.g., number of patients with hypertension . . .
The Use of Dynamic Groups in Psychiatric Staff Reorganization
Authors: H. Mullan
Journal: Psychotherapy and Psychosomatics (1968)

Research Articles| February 12 2010 The Use of Dynamic Groups in Psychiatric Staff Reorganization Subject Area: Psychiatry and Psychology H. Mullan H. Mullan Department of Psychiatry, Georgetown University School of Medicine and Area C Community Mental Health Center, Department of Public Health, Washington, D. C. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1968) 16 (1-3): 146–151. https://doi.org/10.1159/000285928 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation H. Mullan; The Use of Dynamic Groups in Psychiatric Staff Reorganization. Psychother Psychosom 31 December 1968; 16 (1-3): 146–151. https://doi.org/10.1159/000285928 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1968Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
1008-191 Statin therapy is associated with a 67 percent reduction in mortality in patients with severe chronic heart failure: Results from the placebo arm of the ENABLE study
Authors: Olga Milo, Isaac Kobrin, Aline Frey, Loic Perchenet, Edo Kaluski, Nir Uriel, Alex Blatt, Zvi Vered, Gad Cotter
Journal: Journal of the American College of Cardiology (2004)
LOWER NUMBER OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IS ASSOCIATED WITH MYOCARDIAL ISCHEMIA DURING PHYSICAL STRESS
Authors: Ronnie Ramadan, Ibhar Al Mheid, Malik Obideen, David Sheps, Fabio Esteves, Viola Vaccarino, Arshed Quyyumi
Journal: Journal of the American College of Cardiology (2013)
Drosophila Lacking dfmr1 Activity Show Defects in Circadian Output and Fail to Maintain Courtship Interest
Authors: Thomas C. Dockendorff, Henry S. Su, Sean M.J. McBride, Zhaohai Yang, Catherine H. Choi, Kathleen K. Siwicki, Amita Sehgal, Thomas A. Jongens
Journal: Neuron (2002)
P181 Adherence to Treatment in Patients with Bronchiectasis Infected with Pseudomonas Aeruginosa
Authors: A R McCullough, CM Hughes, M Tunney, JS Elborn, JM Bradley
Journal: Thorax (2012)

<h3>Introduction</h3> Patients with bronchiectasis and <i>P. aeruginosa</i> infection are often prescribed a complex regimen of inhaled antibiotics, other respiratory medicines and airway clearance techniques (ACT). Current bronchiectasis guidelines recognise that adherence to treatment is important in this population but no published studies have determined the level of adherence to treatment in patients with bronchiectasis infected with <i>P. aeruginosa.</i> <h3>Aim</h3> The aim of this study was to determine adherence rates to inhaled antibiotics, other respiratory medicines and ACT in patients with bronchiectasis infected with <i>P. aeruginosa</i>. <h3>Methods</h3> Patients with bronchiectasis (confirmed by HRCT) were recruited from hospital respiratory clinics if they had a positive sputum culture for <i>P. aeruginosa</i> and were using inhaled antibiotics. Prescription refill data were used to calculate percentage adherence by dividing the amount collected by the amount prescribed, multiplied by 100. Participants were categorised as adherent (score≥80%) and non-adherent (score&lt;80%) to inhaled antibiotics and other respiratory medicines using this method. Participants completed the modified Self-reported Medication-taking Scale for ACT (score 0–5; adherent score≥4, non-adherent score&lt;4). Spirometry was performed according to ATS/ERS guidelines. Chi square tests were used for between group analyses. <h3>Results</h3> 75 participants were recruited: 24M/51F; mean (SD) age 64 (8) yrs; FEV1 61 (25) % predicted. Sixty-four (85%) participants were prescribed colomycin, 11 (15%) were prescribed tobramycin, 68 (91%) were prescribed bronchodilators and 65 (87%) were prescribed inhaled corticosteroids. All participants were prescribed ACT; active cycle of breathing techniques (n=39, 53%) and Acapella® (n=45, 61%) were most commonly prescribed. Eleven percent (16%) participants were adherent to all treatments. Fifty-two percent and 51% of participants were adherent to inhaled antibiotics and other respiratory medicines, respectively. Thirty-nine percent of participants were adherent to ACT. Adherence category varied significantly between inhaled antibiotics and other respiratory medicines (p=0.04), with 34% of participants being adherent to one treatment and not the other. <h3>Conclusion</h3> Patients with bronchiectasis patients infected with <i>P. aeruginosa</i> have a high burden of treatment. Only 11% of patients were adherent to all treatments, half were adherent to medicines and even fewer were adherent to ACT, indicating that patients make decisions about which treatments to use.
Emerging Concepts in the Treatment of HIV Infection in Children
Authors: Philip A. Pizzo
Journal: JAMA (1989)

<h3>SELECTED CASE</h3> A 16-MONTH-OLD child was considered to have human immunodeficiency virus (HIV) infection at 4 months of age when she developed acute interstitial pneumonia that was documented by open lung biopsy to be caused by<i>Pneumocystis carinii</i>. The patient's mother was known to be HIV seropositive, having presumably acquired the infection from sexual intercourse with the child's father, a known intravenous drug user. The patient's episode with<i>P carinii</i>was stormy, requiring first sulfamethoxazole and trimethoprim and, later, pentamidine isethionate and ventilatory support to reverse the pneumonic process. Following this episode of pneumonia, the child's subsequent course was characterized by recurrent episodes of otitis media and thrush, failure to thrive, hepatosplenomegaly, and a slowed acquisition of normal developmental milestones. At the time of her referral to the Pediatric Branch, National Cancer Institute, for antiretroviral therapy, her CD4 lymphocyte count was 0.115 × 10<sup>3</sup>/L and the CD4/CD8 lymphocyte
Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study
Authors: Susan P. Whitman, Amy S. Ruppert, Guido Marcucci, Krzysztof Mrózek, Peter Paschka, Christian Langer, Claudia D. Baldus, Jing Wen, Tamara Vukosavljevic, Bayard L. Powell, Andrew J. Carroll, Jonathan E. Kolitz, Richard A. Larson, Michael A. Caligiuri, Clara D. Bloomfield
Journal: Blood (2007)
Long-Term Results after Treatment for Recurrent Thymoma: A Multicenter Analysis
Authors: Alberto Sandri, Giacomo Cusumano, Filippo Lococo, Marco Alifano, Pierluigi Granone, Stefano Margaritora, Alfredo Cesario, Alberto Oliaro, Pierluigi Filosso, Jean-Francois Regnard, Enrico Ruffini
Journal: Journal of Thoracic Oncology (2014)
Angiotensin Antibodies and Focal Segmental Glomerulosclerosis
Authors: Nada Alachkar, Gaurav Gupta, Robert A. Montgomery
Journal: New England Journal of Medicine (2013)

This letter describes a case of de novo collapsing focal segmental glomerulosclerosis and antibody-mediated rejection in association with antibodies against the angiotensin II type 1 receptor. Antibody depletion, facilitated by plasmapheresis and losartan, resolved both issues.
Characteristics of patients aged over 75 not seen during one year in general practice
Authors: L. Goldman
Journal: BMJ (1984)

Breast fed babies take about 150 ml/kg of milk in 24 hours.1 Therefore in the case quoted the baby's intake of verapamil would have been 45 ng/kg/24 hours, about 1/100 000 of the maternal dose.I therefore disagree with the authors' conclusion that women receiving verapamil should not breast feed.
Medicolegal aspects of doping in football
Authors: T Graf-Baumann
Journal: British Journal of Sports Medicine (2006)

This article describes the historical background of the medicolegal aspects of doping in sports and especially in football. The definitions of legal terms are explained and the procedure of individual case management as part of FIFA’s approach to doping is presented. Finally, three medicolegal problems awaiting urgent solution are outlined: firstly, the difficulties in decision making arising from the decrease of the T/E ratio from 6 to 4; secondly, the therapeutic application of α-reductase inhibitors for male pattern baldness in the face of the classification of finasteride as a forbidden masking agent; and lastly, the increasing use of recreational drugs and its social and legal implications in positive cases.
Tracheostomy Tube: Cuff Obstruction
Authors: Jonas T. Johnson
Journal: JAMA (1977)

To the Editor.—  A 58-year-old man with end-stage scleroderma was admitted with respiratory failure. The patient subsequently came to tracheostomy, which was carried out under local anesthesia without incident. A polyethylene blue-line softseal cuffed tube was first inflated, found to be normal, and then inserted. The patient did well for two hours, at which time his condition suddenly deteriorated. The diagnosis of tension pneumothorax was made, and he was relieved first by needle puncture, which was followed quickly by tube thoracostomy.  The patient's respiratory condition improved rapidly, only to deteriorate 15 minutes later. At this point, his tracheostomy tube cuff was deflated, and he once again improved. The patient was challenged with cuff inflation only to deteriorate again.  Removal of the tube disclosed a large aneurysmal dilitation. Reinflation in a simulated trachea demonstrated obstruction of the lumen by the abnormal cuff. This created, in effect, a ball-valve mechanism and may
Benign breast swelling.
Authors: R L Meyrick, I Smith
Journal: BMJ (1972)

<h3>ABSTRACT</h3> Intraflagellar transport (IFT) trains are molecular machines that traffic proteins between cilia and the cell body. With a molecular weight over 80 MDa, each IFT train is a dynamic polymer of two large complexes (IFT-A and -B) and motor proteins, posing a formidable challenge to mechanistic understanding. Here, we reconstituted the complete human IFT-A complex and obtained its structure using cryo-EM. Combined with AlphaFold prediction and genome-editing studies, our results illuminate how IFT-A polymerizes; interacts with IFT-B; and uses an array of β-propeller and TPR domains to create “carriages” of the IFT train that engage TULP adaptor proteins. We show that IFT-A·TULP carriages are essential for cilia localization of diverse membrane proteins, as well as ICK – the key kinase regulating IFT train turnaround. These data establish a structural link between IFT-A’s distinct functions, provide a blueprint for the IFT-A train, and shed light on how IFT evolved from a proto-coatomer ancestor.
Reduction of Lumbar Disc Prolapse by Manipulation
Authors: J. A. Mathews, D. A. H. Yates
Journal: BMJ (1969)

In two patients with symptoms and signs characteristic of a mechanical lumbar spine disorder epidurography showed the presence of small disc prolapses. Treatment by manipulation relieved the symptoms of lumbago, and repeat epidurography showed that the prolapses were reduced in size. Reduction of disc prolapse by manipulation has not before been objectively demonstrated.