Celiac Disease
Authors: Sheila E. Crowe
Journal: Annals of Internal Medicine (2011)

In the Clinic3 May 2011Celiac DiseaseDeborah Cotton, MD, MPH, Darren Taichman, MD, PhD, Sankey Williams, MD, and Sheila E. Crowe, MDDeborah Cotton, MD, MPHSearch for more papers by this author, Darren Taichman, MD, PhDSearch for more papers by this author, Sankey Williams, MDSearch for more papers by this author, and Sheila E. Crowe, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-9-201105030-01005 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Celiac disease, also known as gluten-sensitive enteropathy (as well as two older and less preferred terms, nontropical sprue and celiac sprue) is a multisystem disorder estimated to affect approximately 1% of Americans (1). It results from an inappropriate T-cell–mediated immune response to ingested gluten that causes inflammatory injury to the small intestine in genetically predisposed persons. Damage to the proximal small intestinal mucosa results in the malabsorption of nutrients. The average age of diagnosis is in the fifth decade of life but only an estimated 10% to 15% of persons with celiac disease in the United States have been diagnosed ...References1. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003;163:286-92. [PMID: 12578508] Google Scholar2. Kagnoff MF. Celiac disease: pathogenesis of a model immunogenetic disease. J Clin Invest. 2007;117:41-9. [PMID: 17200705] Google Scholar3. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009;137:88-93. [PMID: 19362553] Google Scholar4. 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