Hyperviscosity and Immunoglobulin Complexes
Authors: W. PRUZANSKI
Journal: Annals of Internal Medicine (1974)

Editorial Notes1 January 1974Hyperviscosity and Immunoglobulin ComplexesW. PRUZANSKI, M.D., F.R.C.P.(C.), F.A.C.P.W. PRUZANSKI, M.D., F.R.C.P.(C.), F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-1-107 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the coming era of computerized medicine and automated science, there will still be a place for old-fashioned clinical observations. New clinical syndromes are still being discovered, and old ones are being redefined by new scientific knowledge.The clinical manifestations of blood hyperviscosity in macroglobulinemia and multiple myeloma were described many years ago (1, 2). Hyperviscosity in these two diseases is caused by a very high concentration of an M component in the serum, by aggregation of or by high intrinsic viscosity of the immunoglobulin molecules. In other diseases, such as polycythemia, thrombocythemia, or leukemia, hyperviscosity results from an abnormally...References1. PRUZANSKIWATT WJ: Serum viscosity and hyperviscosity syndrome in IgG multiple myeloma. Report on 10 patients and a review of the literature. Ann Intern Med 77:853-860, 1972 LinkGoogle Scholar2. BLOCHMAKI KD: Hyperviscosity syndromes associated with immunoglobulin abnormalities. Semin Hematol 10:113-124, 1973 MedlineGoogle Scholar3. MELTZERFRANKLINELIAS MEK: Cryoglobulinemia—a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity. Am J Med 40:837-856, 1966 CrossrefMedlineGoogle Scholar4. HOLLINGSWORTH J: Local and Systemic Complications of Rheumatoid Arthritis. Philadelphia, W. B. Saunders Co., 1968, p. 97 Google Scholar5. ABRUZZOHEIMERGIULIANO JRV: The hyperviscosity syndrome, polysynovitis, polymyositis and an unusual 13S serum IgG component. Am J Med 49:258-264, 1970 CrossrefMedlineGoogle Scholar6. JASINLOSPALLUTOZIFF HJM: Rheumatoid hyperviscosity syndrome. Ibid., pp. 484-493 Google Scholar7. BONNERENNISGEELHOED HRG: Lymphoid infiltration and amyloidosis of lung in Sjögren's syndrome. Arch Pathol 95:42-44, 1973 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHyperviscosity SyndromeNeurologic symptoms and complications of monoclonal gammophatiesBiochemical markers of disease activityPlasmapheresis and Cold Sensitivity of Immunoglobulin MoleculesPLASMA VISCOSITY CHANGES IN CUTANEOUS VASCULITISPathogenic role of a monoclonal IgA (?) anti-IgG paraprotein associated with hemorrhagic diathesis, rheumatoid arthritis, vascular purpura, and acute membranoproliferative glomerulonephritisThe physical characterization of an aggregating IgG heteropolymer containing rheumatoid factor.Rheumatoid arthritis with Felty's syndrome, hyperviscosity and immunologic hyperreactivityPolyclonal Hyperviscosity SyndromeElectroencephalographic and Encephalopathic Findings in Multiple Myeloma: Hyperviscosity versus Hypercalcemia 1 January 1974Volume 80, Issue 1Page: 107-107KeywordsAttentionBloodComputersMultiple myelomaPolycythemiaThrombocytosis ePublished: 1 December 2008 Issue Published: 1 January 1974 PDF downloadLoading ...