tbuckley/cabot-search huggingface dataset:
Coronary Artery Responses to Physiological Stimuli Are Improved by Deferoxamine but not by <scp>l</scp> -Arginine in Non–Insulin-Dependent Diabetic Patients With Angiographically Normal Coronary Arteries and No Other Risk Factors
Authors: Alain Nitenberg, Frédéric Paycha, Séverine Ledoux, Régis Sachs, Jean-Raymond Attali, Paul Valensi
Journal: Circulation (1998)

Background —Acetylcholine produces coronary artery (CA) constriction in diabetic patients, suggesting an impairment of endothelium-dependent dilation. In diabetes, multiple metabolic abnormalities may inactivate nitric oxide through oxygen free radical production. Methods and Results —To examine the mechanism of this abnormal response, two physiological tests (ie, a cold pressor test [CPT] and coronary flow increase induced by an injection of 10 mg papaverine [PAP] in the distal left anterior descending CA) were performed before and after either intravenous l -arginine (625 mg/min×10 minutes) or intravenous deferoxamine (50 mg/min×10 minutes) in 22 normotensive nonsmoking diabetic patients with angiographically normal CAs and normal cholesterol. Coronary surface areas were measured with quantitative angiography. Before the administration of l -arginine or deferoxamine, CPT induced CA constriction in both groups (−14±10% and −15±11%, respectively; each P &lt;.001), and PAP injection in distal LAD did not modify significantly proximal LAD dimensions. In the 10 diabetic patients receiving l -arginine, responses to CPT and PAP were not modified. Conversely, in the 12 patients receiving deferoxamine, CA dilated in response to the two tests (+10±9% after CPT and +22±7% after PAP, each P &lt;.001). Intracoronary isosorbide dinitrate, an endothelium-independent dilator, produced similar dilation in the two groups (+47±19% and +41±15%, respectively; each P &lt;.001). Conclusions —This study shows that (1) responses of angiographically normal CAs to CPT and to flow increase are impaired in diabetic patients; (2) abnormal responses are not improved by l -arginine, suggesting that a deficit in substrate for nitric oxide synthesis is not involved; and (3) deferoxamine restores a vasodilator response to the two tests, suggesting that inactivation of NO by oxygen species might be partly responsible for the impairment of CA dilation in diabetic patients.
Low rate of treatment of hypercholesterolemia by cardiologists in patients with suspected and proven coronary artery disease.
Authors: M V Cohen, M J Byrne, B Levine, T Gutowski, R Adelson
Journal: Circulation (1991)

Although specific guidelines for the treatment of hypercholesterolemia have been published, it is not known whether physicians treating patients likely to have lipid disorders have adopted the recommendations.The approach of cardiologists to the treatment of hypercholesterolemia in a metropolitan teaching hospital was assessed by interviewing patients with chest pain who were admitted for coronary angiography in 1988-1989 and by measuring fasting blood lipid profiles. At 1 month and again 12-24 months later, patients were contacted by telephone to determine if there had been any changes in treatment. Of 95 patients evaluated, 81 had coronary artery disease. Only 17% of those with high levels of total cholesterol and/or low density lipoprotein cholesterol were being actively treated with diet and/or drugs. In the remaining patients, either lipid studies had not been done or abnormal results had not been addressed. There was little change in treatment approach during the month after the diagnostic procedure. Furthermore, the experience was similar in those patients subjected to coronary revascularization. One to 2 years after the initial intervention, 69 of the original study group could be contacted again. Although active dietary or pharmacological therapy was initiated in some individuals during this interval, it was stopped in others. Thirty-five percent of hypercholesterolemic patients were receiving targeted therapy.Thus, only a small proportion of patients with documented coronary artery disease and hypercholesterolemia were being actively treated for their lipid disorder, suggesting that the published treatment guidelines have not yet been fully accepted. However, an encouraging improvement in frequency of treatment of hypercholesterolemia was documented during the 1-2-year observation period.
The South Inflamed! The Case of Henry Wirz-Reply
Authors: Andrew Skolnick
Journal: JAMA (1991)

In Reply. —  I regret that Farr thinks my article ridicules or demeans people of southern heritage. Nevertheless, he and Hardy have no basis to accuse me of failing to do my homework. In none of my sources 1-8 was Henry Wirz identified as a major. Two of these references 1,7 identify him as a physician. In addition, one source cited by Farr 9 says that Wirz graduated from the University of Zurich, received medical training at schools in Paris and Berlin, and apprenticed with a physician in Kentucky, after which he set up a medical practice in Louisiana. I never said Wirz was a Confederate medical corps officer, as Farr and Hardy assert.  I am puzzled by Farr's accusation that my view of Confederate medicine was biased, for I did not express a view of Confederate medicine. Nor was I writing about the Confederacy or Farr's ancestors. I briefly described
Role of ln-111 Labeled Leukocyte Scintigraphy in the Diagnosis of Intracerebral Lesions
Authors: CHRISTOPHER J. PALESTRO, ALFRED J. SWYER, CHUN K. KIM, MICHAEL MUZINIC, STANLEY J. GOLDSMITH
Journal: Clinical Nuclear Medicine (1991)

The differential diagnosis of intracerebral enhancing lesions on contrast computed tomography includes tumors, abscesses, and cerebrovascular accidents. Particularly important is the differentiation between tumor and abscess. While ln-111 labeled leukocyte imaging is an accurate test for identification of foci of infection in general, the role of this procedure in the evaluation of the intracranial lesion is not well established. We undertook a retrospective review of 16 patients with contrast enhancing intracerebral lesions identified on computed tomography, who were also studied with labeled leukocyte imaging. Final diagnoses were: abscess (n=2), primary brain tumor (n=6), metastasis (n=4), dermoid cyst (n=1), and cerebral infarct (n=3). There were two positive labeled leukocyte studies; both were cerebral abscesses. No labeled leukocyte activity was identified in any of the tumors or infarcts. We conclude that ln-111 labeled leukocyte imaging is an accurate method of differentiating infectious from noninfectious causes of intracerebral lesions identified on computed tomography.
Proximal Lower-Limb Weakness in Charcot-Marie-Tooth Disease—Reply
Authors: Ki Wha Chung, Sang Soo Lee, Young Bin Hong, Jeong Hyun Yoo, Byung-Ok Choi
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
WET DRESSINGS IN SURGERY.
Authors: THOMAS OSMOND SUMMERS
Journal: JAMA (1898)

This may well be called the<i>dressing period</i>in the evolution of surgery. Time was when the scape! alone was emblazoned on the escutcheon of the surgeon and with the skillful incision his responsibility ended, nor did the dignity of his office admit of his performing what then were held as the minor and menial offices of<i>after treatment</i>which then was supposed to cover everything that followed upon the first brilliant sweep of the surgeon's glittering steel. There are no doubt some who hear me today who remember the dramatic toss of the knife behind him of the elder Gross whon completing his incision and the autocratic delivery of the case to his assistants for the dressing and treatment of the wound. Even to this day the red, white and blue stripes of the barber pole tell of surgery's humble origin and the bandagers and bone-setters still roam
Oestrogen treatment for menopausal flushing.
Authors: G Mulley, J R Mitchell
Journal: BMJ (1977)

matching was attempted with total sample sizes of 2779 and 12 588 respectively showed no differences in birth weight or of the incidence of preterm (<37 weeks' gestation) delivery.Thus the evidence that is available does not support the idea that modern legal abortion generally increases the risks of prematurity in a subsequent pregnancy.The question raised in the BMJ interview that still has to be answered is whether the reduction in the incidence of low birth weight can be ascribed to legal abortion.
The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure
Authors: Pablo Ureña, Marcos Kubrusly, Michael Mannstadt, Milan Hruby, Marie-Marcelle Trinh Trang Tan, Caroline Silve, Bernard Lacour, Abdul-Badi Abou-Samra, Gino V. Segre, Tilman Drüeke
Journal: Kidney International (1994)
Presence of CD45RO+ CD34+ cells with collagen synthesis activity in nephrogenic fibrosing dermopathy: a new pathogenic hypothesis
Authors: N. Ortonne, D. Lipsker, F. Chantrel, N. Boehm, E. Grosshans, B. Cribier
Journal: British Journal of Dermatology (2004)

Sir, Nephrogenic fibrosing dermopathy (NFD) is a recently described entity. Cowper et al. described the first series of 14 patients and coined the term NFD.1, 2 Since the original description, 10 additional cases have been reported,3–6 one of them having systemic involvement. The aetiology and pathogenesis of NFD are unknown, but it occurs exclusively in patients with renal dysfunction. It has therefore been hypothesized that NFD could be triggered by new drugs used to treat patients with chronic renal insufficiency, or by new biological materials employed in dialysis. We report two further patients with NFD: women aged 50 years and 52 years. They were undergoing haemodialysis because of chronic renal insufficiency due to diabetic nephropathy and membranoproliferative glomerulonephritis, respectively. Both patients had indurated erythematous plaques with sharp delimitation and geographical borders on their legs and thighs (Fig. 1A,B). Patient 2 also had lesions on the forearms and hands resulting in mobility impairment. The lesions had a yellowish colour on vitropression. Standard coagulation tests were normal and there were no anticardiolipin or antiphospholipid antibodies. In patient 2, antinuclear antibodies were present at a high titre (1 : 1280), but there were no anti‐Sm, anti‐Sa, anti‐RNP, anti‐Lm or antidouble‐stranded DNA antibodies. The presence of antinuclear antibodies was therefore interpreted as a false positivity or as a consequence of chronic renal failure and dialysis. No specific treatment was given. However, in both patients, we observed during follow‐up that some lesions spontaneously regressed, while new lesions appeared. As some lesions of NFD can partially heal spontaneously, evaluation of the efficiency of future treatments for NFD should be done with caution.
Gulf war syndrome
Authors: F. M Murphy
Journal: BMJ (1999)

Papers p 290 

By the end of the Gulf War in February 1991 US, British, and Canadian forces had deployed about 697 000, 53 000, and 4500military personnel, respectively, to south west Asia. The conflict required rapid mobilisation of coalition combat troops, and massive numbers of casualties were expected.1 An extensive medical infrastructure and preventive medicine effort was deployed to support the troops. 2 3 During the operation service personnel were exposed to a wide variety of known and potential health hazards. These exposures included smoke from oil well fires, extremes of hot and cold weather, petroleum products and fumes, depleted uranium, pesticides, endemic infectious diseases, and other physical and psychological stressors. The preparations for war included training in chemical warfare, immunisation against certain biological warfare agents, and use of the nerve agent protection pill, pyridostigmine bromide.

Despite the arduous conditions, morbidity rates among US troops were lower than in previous wars. 4 5 Mortality was also much lower than expected. Altogether 372 deployed US troops died in 1990-1: 40% from combat, 52% from accidents (primarily related to training and motor vehicles), and 8% from illness.6 Illnesses in Gulf War veterans have been a source of intense controversy on both sides of the Atlantic. Since 1991 many veterans and their families have voiced concerns about possible health consequences of their service, and many have complained of being unwell, reporting a wide array …
Dubois' Lupus Erythematosus
Authors: Daniel J. Wallace
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 September 1988Dubois' Lupus ErythematosusDaniel J. Wallace, MDDaniel J. Wallace, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-5-436_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Regarding Dr. Mandell's letter (1) in the June issue, I also am quite dismayed that our textbook,Dubois' Lupus Erythematosus(3rd edition), was not included in A Library for Internists (2). We received excellent notices from nearly every journal that reviewed our book. TheNew England Journal of Medicineand theJournal of the American Medical Associationdescribed our book as the definitive authoritative reference text in the field. Concerning your response to Dr. Mandell, the book is recent (1987), available, and widely known. I agree with your suggestion that a more comprehensive list is needed. Exclusion...References1. Mandell G. Omissions from A Library for Internists [Letter]. Ann Intern Med. 1988;108:939. Google Scholar2. Huth E. A library for internists VI: recommendations from the American College of Physicians. Ann Intern Med. 1988;108:497-512. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, CA 90048 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNewer Therapeutic Approaches for Systemic Lupus Erythematosus: Immunosuppressive AgentsStudies on the mechanism of thrombocytopenia observed in murine systemic lupus erythematosus 1 September 1988Volume 109, Issue 5Page: 436-437KeywordsLibrariesLupus erythematosus Issue Published: 1 September 1988 PDF downloadLoading ...
Meningoencephalitis Associated With Pneumonitis Due to Mycoplasma pneumoniae
Authors: Marc J. Taylor
Journal: JAMA (1967)

Three patients had pneumonitis complicated by severe, prolonged meningoencephalitis, followed by recovery without significant neurologic residua. In all three patients there was specific serologic evidence of infection with<i>Mycoplasma pneumoniae</i>. Meningoencephalitis associated with<i>M pneumoniae</i>appears to be rare, but infection with this agent deserves consideration in otherwise unexplained cases of encephalitis.
A plasma inhibitor of ristocetin‐induced platelet aggregation in patients with sickle hemoglobinopathies
Authors: David A. Leichtman, George J. Brewer
Journal: American Journal of Hematology (1977)

Abstract Because of the high prevalence of thrombotic complications in patients with sickle cell anemia (SCA), we investigated platelet function in patients with sickle hemoglobinopathies. Platelet aggregation induced by epinephrine, ADP, and collagen, except for absent secondary wave in 3 of 10 patients with SCA, was qualitatively normal. However, ristocetin‐induced platelet aggregation (RIPA) with a final concentration of 1.12 mg/ml was markedly abnormal – absent or virtually absent in 9 of 10 patients with SCA, 3 of 3 patients with hemoglobin S‐C disease, and 2 of 3 patients with sickle trait. All 8 controls used in these experiments repeatedly demonstrated normal RIPA. Addition of normal plasma failed to correct abnormal RIPA in sickle hemoglobinopathy patients. All patients demonstrated normal RIPA with a ristocetin dose of 2.24 mg/ml and aggregated with bovine fibrinogen. Recombinant mixing experiments demonstrated that washed SCA platelets support RIPA (1.12 mg/ml) when resuspended in normal plasma or high dilutions of SCA plasma, but not in undiluted SCA plasma. Washed normal platelets do not support RIPA (1.12 mg/ml) when resuspended in SCA plasma. These findings suggest the presence of a plasma inhibitor of RIPA in patients with sickle hemoglobinopathies.
Primary follicular lymphoma of the gastrointestinal tract: a retrospective case series
Authors: M. Kodama, Y. Kitadai, T. Shishido, M. Shimamoto, A. Fukumoto, H. Masuda, S. Tanaka, M. Yoshihara, A. Sakai, H. Nakayama, K. Chayama
Journal: Endoscopy (2007)

Little is known about the clinicopathologic characteristics of primary follicular lymphoma of the gastrointestinal tract (PFLGI). We report our experience with double-balloon enteroscopy (DBE) in patients with PFLGI. Between January 2001 and December 2006, thirteen patients with PFLGI (nine men and four women; mean age, 53.4 years) visited Hiroshima University Hospital. We performed DBE in 11 PFLGI patients to examine the entire small bowel. DBE showed new lesions in the third portion of the duodenum, jejunum, or ileum in nine of these 11 patients (81.8 %). The endoscopic finding was nodularity of the involved mucosal surface (small whitish polyps or whitish granules). Seven patients were treated with rituximab plus CHOP chemotherapy (R-CHOP). A complete response was obtained in all patients who received R-CHOP, and no recurrence was seen (mean follow-up period, 22.5 months).
Postallergen inhaled budesonide reduces late asthmatic response and inhibits the associated increase of airway responsiveness to methacholine in asthmatics.
Authors: P L Paggiaro, F L Dente, M C Morelli, L Bancalari, A Di Franco, D Giannini, B Vagaggini, E Bacci, L M Fabbri, C Giuntini
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

To determine whether inhaled budesonide given after allergen inhalation challenge inhibits the late asthmatic response (LAR) and/or the associated increase of airway responsiveness to methacholine, we performed a double-blind randomized cross-over study in 12 adult asthmatics (eight male, four female; mean age, 20.3 yr; range, 18 to 29 yr) sensitized to Dermatophagoides pteronyssinus (DP) previously shown to develop early and late asthmatic response to allergen challenge with DP. On different days each subject was randomized to receive budesonide 800 micrograms by Turbuhaler or placebo, given three times; (1) after allergen inhalation, after the onset of LAR, when FEV1 had fallen by > or = 15%; (2) 2 h later; (3) 4 h later. Airway responsiveness to methacholine was measured before allergen challenge at 8 to 10 h from allergen inhalation and 24 h after the allergen inhalation. Inhaled budesonide significantly reduced the LAR induced by allergen (maximal % fall in FEV1, delta FEV1%: -23 +/- 6% with budesonide versus -38 +/- 9% with placebo; p < 0.001) and inhibited the associated increase of airway responsiveness (geometric mean of PD20FEV1 methacholine: 0.047 mg after budesonide versus 0.033 mg after placebo at 8 to 10 h, p < 0.05; 0.119 mg after budesonide versus 0.062 mg after placebo at 24 h, p < 0.01). These results suggest that inhaled budesonide may not only prevent but also reduce the late asthmatic response induced by allergen and that it might also be considered in the treatment of exacerbation of asthma.
Unusual Tl-201 Scintigraphic Findings in Intralesional Hemorrhagic Schwannoma of the Knee
Authors: Ildikó Garai, Zoltán Csiki, Gabriella Szücs, Jószef Varga, László Galuska
Journal: Clinical Nuclear Medicine (2003)

Most schwannomas are negative on Tl-201 imaging. The authors present an unusual case of schwannoma of the knee in a 58-year-old woman, in whom the Tl-201 study revealed increased uptake of isotope on both early and delayed images. Magnetic resonance imaging showed inhomogeneous hypointensity on the T1 weighted images, and a mixture of hypo-, hyper-, and isointensity of muscle on the short tau inversion recovery images. Histologic examination of the excised tumor showed wide hemorrhagic areas, multiple cysts, hemosiderin deposits, granulation tissue, and solid areas of tumor consistent with conventional schwannoma.
The power of doing nothing
Authors: Des Spence
Journal: BMJ (2013)

<h3>Background</h3> We aimed to determine the relative frequency of affected cerebrovascular territories in patients with atrial fibrillation (AF) suffering an ischemic stroke. <h3>Methods</h3> Altogether, 1,976 patients who suffered their first-ever ischemic stroke during 2003–2012 and were diagnosed with AF either before or within 30 days after the event were included in this retrospective multicenter cohort study. Strokes were classified radiographically to be located either within the anterior or the posterior cerebrovascular territory, and the effect of the CHA<sub>2</sub>DS<sub>2</sub>-VASc score, oral anticoagulant (OAC) use, and timing of AF diagnosis on lesion localization was determined. <h3>Results</h3> The median age of the patients was 78.4 (interquartile range: 71.7–84.2) years, 1,137 (57.5%) of them were women, their mean CHA<sub>2</sub>DS<sub>2</sub>-VASc score was 3.5 (95% confidence interval: 3.4–3.5), 656 (33.2%) were receiving OAC drugs, and altogether, 1,450 (73%) had a previous AF diagnosis. The localization of ischemic lesions between the anterior and the posterior cerebrovascular territories was not affected by the timing of AF diagnosis (<i>p</i> = 0.46), use of OACs (<i>p</i> = 0.70), or the CHA<sub>2</sub>DS<sub>2</sub>-VASc score (<i>p</i> = 0.10). Within the anterior territory, altogether 774 strokes (53.2%) were located in the left hemisphere and 3 (0.2%) were bilateral. The timing of AF diagnosis (<i>p</i> = 0.84), use of OACs (<i>p</i> = 0.90), or the CHA<sub>2</sub>DS<sub>2</sub>-VASc score (<i>p</i> = 0.21) did not affect the location of the ischemic lesion between the hemispheres. <h3>Conclusions</h3> The timing of AF diagnosis, use of OAC drugs, or the CHA<sub>2</sub>DS<sub>2</sub>-VASc score did not affect the distribution of ischemic strokes. Anterior territory strokes were slightly more often located within the left hemisphere.