tbuckley/cabot-search huggingface dataset:
CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury
Authors: Callisia Clarke, Satoshi Kuboki, Nozomu Sakai, Kevin R. Kasten, Amit D. Tevar, Rebecca Schuster, John Blanchard, Charles C. Caldwell, Michael J. Edwards, Alex B. Lentsch
Journal: Hepatology (2010)

CXC chemokines mediate hepatic inflammation and injury following ischemia/reperfusion (I/R). More recently, signaling through CXC chemokine receptor-2 (CXCR2) was shown to delay liver recovery and repair after I/R injury. The chemokine receptor CXCR1 shares ligands with CXCR2, yet nothing is known about its potential role in liver pathology. In the present study, we examined the role of CXCR1 in the injury and recovery responses to I/R using a murine model. CXCR1 expression was undetectable in livers of sham-operated mice. However, after ischemia CXCR1 expression increased 24 hours after reperfusion and was maximal after 96 hours of reperfusion. CXCR1 expression was localized largely to hepatocytes. In order to assess the function of CXCR1, CXCR2(-/-) mice were treated with the CXCR1/CXCR2 antagonist, repertaxin. Prophylactic treatment with repertaxin had no effect on acute inflammation or liver injury. However, when repertaxin was administered 24 hours postreperfusion there was a significant increase in hepatocellular injury and a delay in recovery compared to control-treated mice. CXCR1(-/-) mice also demonstrated delayed recovery and regeneration after I/R when compared to wild-type mice. In vitro, hepatocytes from CXCR2(-/-) mice that were stimulated to express CXCR1 showed increased proliferation in response to ligand. Hepatocyte proliferation was decreased in CXCR1(-/-) mice in vivo. This is the first report to show that CXCR1 expression is induced in hepatocytes after injury. Furthermore, the data suggest that CXCR1 has divergent effects from CXCR2 and appears to facilitate repair and regenerative responses after I/R injury.
Levels of lead in breast milk and their relation to maternal blood and bone lead levels at one month postpartum.
Authors: Adrienne S Ettinger, Martha María Téllez-Rojo, Chitra Amarasiriwardena, Teresa González-Cossío, Karen E Peterson, Antonio Aro, Howard Hu, Mauricio Hernández-Avila
Journal: Environmental Health Perspectives (2004)

Despite the many well-recognized benefits of breast-feeding for both mothers and infants, detectable levels of lead in breast milk have been documented in population studies of women with no current environmental or occupational exposures. Mobilization of maternal bone lead stores has been suggested as a potential endogenous source of lead in breast milk. We measured lead in breast milk to quantify the relation between maternal blood and bone lead levels and breast-feeding status (exclusive vs. partial) among 310 lactating women in Mexico City, Mexico, at 1 month postpartum. Umbilical cord and maternal blood samples were collected at delivery. Maternal breast milk, blood, and bone lead levels were obtained at 1 month postpartum. Levels of lead in breast milk ranged from 0.21 to 8.02 microg/L (ppb), with a geometric mean (GM) of 1.1 microg/L; blood lead ranged from 1.8 to 29.9 microg/dL (GM = 8.4 microg/dL); bone lead ranged from < 1 to 67.2 microg/g bone mineral (patella) and from < 1 to 76.6 microg/g bone mineral (tibia) at 1 month postpartum. Breast milk lead was significantly correlated with umbilical cord lead [Spearman correlation coefficient (rS) = 0.36, p < 0.0001] and maternal blood lead (rS= 0.38, p < 0.0001) at delivery and with maternal blood lead (rS = 0.42, p < 0.0001) and patella lead (rS= 0.15, p < 0.01) at 1 month postpartum. Mother's age, years living in Mexico City, and use of lead-glazed ceramics, all predictive of cumulative lead exposure, were not significant predictors of breast milk lead levels. Adjusting for parity, daily dietary calcium intake (milligrams), infant weight change (grams), and breast-feeding status (exclusive or partial lactation), the estimated effect of an interquartile range (IQR) increase in blood lead (5.0 microg/dL) was associated with a 33% increase in breast milk lead [95% confidence interval (CI), 24 to 43%], whereas an IQR increase in patella lead (20 microg/g) was associated with a 14% increase in breast milk lead (95% CI, 5 to 25%). An IQR increase in tibia lead (12.0 microg/g) was associated with a 5% increase in breast milk lead (95% CI, -3% to 14%). Our results indicate that even among a population of women with relatively high lifetime exposure to lead, levels of lead in breast milk are low, influenced both by current lead exposure and by redistribution of bone lead accumulated from past environmental exposures.
[161] HEPATITIS E VIRUS INFECTION CAN EVOLVE TO CHRONIC HEPATITIS IN ORGAN-TRANSPLANT PATIENTS
Authors: N. Kamar, J.M. Peron, L. Ouezzani, J.M. Mansuy, J. Selves, J. Guitard, O. Cointault, C. Bureau, D. Durand, J.P. Vinel, J. Izopet, L. Rostaing
Journal: Journal of Hepatology (2007)
Hepatitis C virus viral recurrence and liver mitochondrial damage after liver transplantation in HIV–HCV co-infected patients
Authors: Jean-Charles Duclos-Vallée, Daniel Vittecoq, Elina Teicher, Cyrille Feray, Anne-Marie Roque-Afonso, Anne Lombès, Claude Jardel, Michelle Gigou, Elisabeth Dussaix, Mylène Sebagh, Catherine Guettier, Daniel Azoulay, René Adam, Philippe Ichaï, Faouzi Saliba, Bruno Roche, Denis Castaing, Henri Bismuth, Didier Samuel
Journal: Journal of Hepatology (2004)
Transverse Myelitis Associated With Cat-Scratch Disease in an Adult
Authors: Robert G. Pickerill
Journal: JAMA (1981)

CAT-SCRATCH disease, also known as nonbacterial regional lymphadenitis, is an uncommon illness that afflicts children primarily and was first reported in the literature by Debre et al<sup>1</sup>in 1950. The disease is usually mild and self-limited and is characterized by subacute regional lymphadenitis, fever, and malaise. The causative agent is unknown, and no consistently effective medical treatment has yet been described. Neurological manifestations are rare and have been recognized since 1952, when the first case report of encephalitis associated with cat-scratch disease was published by Stevens.<sup>2</sup>An additional 24 cases with neurological complications have been described in the English-language literature since then.<sup>3-7</sup>The majority of these are reports of encephalopathy and convulsions. To our knowledge, there are only two cases of myelitis and radiculitis.<sup>8,9</sup>Both patients were younger than 18 years. We describe a case of cat-scratch disease in a 44-year-old adult complicated by myelitis presenting
Traffic-Related Air Pollution and Asthma Onset in Children: A Prospective Cohort Study with Individual Exposure Measurement
Authors: Michael Jerrett, Ketan Shankardass, Kiros Berhane, W. James Gauderman, Nino Künzli, Edward Avol, Frank Gilliland, Fred Lurmann, Jassy N. Molitor, John T. Molitor, Duncan C. Thomas, John Peters, Rob McConnell
Journal: Environmental Health Perspectives (2008)

The question of whether air pollution contributes to asthma onset remains unresolved.In this study, we assessed the association between asthma onset in children and traffic-related air pollution.We selected a sample of 217 children from participants in the Southern California Children's Health Study, a prospective cohort designed to investigate associations between air pollution and respiratory health in children 10-18 years of age. Individual covariates and new asthma incidence (30 cases) were reported annually through questionnaires during 8 years of follow-up. Children had nitrogen dioxide monitors placed outside their home for 2 weeks in the summer and 2 weeks in the fall-winter season as a marker of traffic-related air pollution. We used multilevel Cox models to test the associations between asthma and air pollution.In models controlling for confounders, incident asthma was positively associated with traffic pollution, with a hazard ratio (HR) of 1.29 [95% confidence interval (CI), 1.07-1.56] across the average within-community interquartile range of 6.2 ppb in annual residential NO2. Using the total interquartile range for all measurements of 28.9 ppb increased the HR to 3.25 (95% CI, 1.35-7.85).In this cohort, markers of traffic-related air pollution were associated with the onset of asthma. The risks observed suggest that air pollution exposure contributes to new-onset asthma.
In vitro corrosion behaviour and osteoblast response of thermally oxidised Ti6Al4V alloy
Authors: M.C Garcı́a-Alonso, L Saldaña, G Vallés, J.L González-Carrasco, J González-Cabrero, M.E Martı́nez, E Gil-Garay, L Munuera
Journal: Biomaterials (2002)
Development of the acinus in the human lung
Authors: A. Hislop, L. Reid
Journal: Thorax (1974)

<b>Hislop, Alison, and Reid, Lynne (1974).</b><i>Thorax</i>, <b>29</b>, 90-94. <b>Development of the acinus in the human lung.</b> Development and remodelling of the acinus (those structures distal to the terminal bronchiolus) occurs during fetal life and childhood. Multiplication of the acinar air spaces and the structural changes they undergo have been described and represented schematically by summarizing previous studies, particularly those of the last two decades. Most acinar airways are present before birth. Future respiratory bronchioli are represented by the 19th intrauterine week; alveolar ducts are present as saccules by the 28th week. Alveolar sacs and alveoli, as properly described, do not appear until after birth: alveoli increase in number, particularly in the first seven or so years of life, and in size with thoracic growth.
Evaluation of infradiaphragmatic total anomalous pulmonary venous connection with two-dimensional echocardiography.
Authors: A R Snider, N H Silverman, K Turley, P A Ebert
Journal: Circulation (1982)

In three newborn infants with infradiaphragmatic total anomalous pulmonary venous connection, the common pulmonary vein was visualized with two-dimensional echocardiography and validated with saline contrast injections. The transducer was placed in the subcostal region in a sagittal body plane so as to image the descending aorta and the vertebral column. The common pulmonary vein, which connected the pulmonary veins to a systemic vein in the abdomen, was seen lying parallel and anterior to the descending aorta and to the left of the inferior vena cava. With peripheral venous contrast injections, contrast echoes first filled the inferior vena cava and then the descending aorta because of obligatory right-to-left atrial shunting. The common pulmonary vein was the only structure that remained free of contrast echoes. Thus, contrast echocardiography provided a method for identifying the site of pulmonary venous drainage and for distinguishing the common pulmonary vein from other structures such as the inferior vena cava. In cyanotic infants with respiratory distress, two-dimensional contrast echocardiography permits a rapid diagnosis of infradiaphragmatic total anomalous pulmonary venous connection.
Adrenergic regulation of myosin adenosine triphosphatase activity.
Authors: S Winegrad, A Weisberg, L E Lin, G McClellan
Journal: Circulation Research (1986)

The amount of inorganic phosphate liberated by the adenosine triphosphatase activity of myosin in a thin section of cardiac tissue can be measured quantitatively by precipitation with calcium in an alkaline medium under a defined set of conditions. Specificity of the procedure for myosin adenosine triphosphatase has been confirmed by the response to inhibitors and to different degrees of contractile filament overlap. Precise quantitation of adenosine triphosphatase activity has been demonstrated by (1) constant rate over time, (2) linearity with amount of enzyme, (3) correct values for the Km of adenosine triphosphate, and (4) a similar value for Vmax to those determined by more traditional procedures. Stimulation of the beta-adrenergic system by the release of catecholamines following injection of the animal with 6-hydroxydopamine causes a rise and then a fall of both calcium- and actin-activated adenosine triphosphatase in parallel with the changes in blood levels of the transmitter. Tyramine injection of rats produces a dose related increase in myosin adenosine triphosphatase. Perfusion of isolated hearts with isoproterenol increases myosin adenosine triphosphatase in dose-related manner. Addition of cyclic adenosine monophosphate and phosphodiesterase inhibitor to the solution bathing frozen, dried sections of heart increases both calcium- and actin-activated adenosine triphosphatase activity by almost 150%. The data show that the beta-adrenergic system, through cyclic adenosine monophosphatate, regulates the enzymatic activity of myosin, independent of the concentration of calcium. The possible role of this regulatory mechanism in the physiological modulation of cardiac contractility is discussed.
Potentiation of Warfarin Anticoagulation by Acetaminophen
Authors: W. R. Bartle
Journal: JAMA (1991)

<h3>To the Editor.—</h3> Acetaminophen is not thought to interact with warfarin, and patients receiving this oral anticoagulant are frequently told that they can safely use this analgesic-antipyretic in place of aspirin. We recently admitted a patient who was receiving warfarin to our hospital with bleeding closely associated with concurrent acetaminophen ingestion. <h3>Report of a Case.—</h3> A 66-year-old woman presented to Sunnybrook Health Science Centre, North York, Ontario, on June 8 with a 3-day history of hematuria and gingival bleeding. Her past pertinent medical history included a stroke in 1986 for which warfarin was prescribed. She has been followed up in the Anticoagulation Clinic on a monthly basis since then. Her average daily warfarin dose has been 3 mg/d to maintain a prothrombin time between 15 and 19 seconds; her highest prothrombin value over this time was 23 seconds. In late May 1990, an acetaminophen-codeine combination was prescribed for a recurring
<i>JAK2</i>Mutations in Polycythemia Vera — Molecular Mechanisms and Clinical Applications
Authors: Ayalew Tefferi
Journal: New England Journal of Medicine (2007)

Janus kinase 2 (JAK2) is a cytoplasmic tyrosine kinase that transduces signals, especially those triggered by hematopoietic growth factors such as erythropoietin, in normal and neoplastic cells. In March and April 2005, four groups of investigators reported finding an acquired JAK2 mutation (termed JAK2 V617F) in association with polycythemia vera and related myeloproliferative disorders.1 These seminal reports have already been cited many times, and JAK2 is now a target for the development of new treatments for the myeloproliferative disorders. JAK2 V617F is detectable in more than 95% of patients who have polycythemia vera, as defined according to conventional criteria. The . . .
617 RELATIONSHIP BETWEEN SMALL INTESTINAL BACTERIAL OVERGROWTH AND INTESTINAL PERMEABILITY IN CIRRHOSIS
Authors: E. Scarpellini, A. Cazzato, M. Gabrielli, A. Tortora, F. Purchiaroni, M.E. Ainora, L. Sparano, G. Gasbarrini, V. Valenza, A. Gasbarrini
Journal: Journal of Hepatology (2011)
Influenza Vaccination in 2013-2014
Authors: Kathleen M. Neuzil
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis of small-bowel metastasis of malignant pleural mesothelioma by capsule endoscopy and double ballon enteroscopy
Authors: Y. Kakugawa, S. Watanabe, N. Kobayashi, M. Tani, S. Tanaka, K. Tsuta, D. Saito
Journal: Endoscopy (2007)

A 62-year-old man who was diagnosed with malignant pleural mesothelioma ([Fig. 1]) underwent right extrapleural pneumonectomy. He was followed up with chest radiographs, computed tomographic scans, and laboratory investigations, none of which showed any findings. Nine months later, he was readmitted for the investigation of tarry stools and iron deficiency anemia. Esophagogastroduodenoscopy, total colonoscopy, red blood cell scintigraphy, and computed tomography did not identify any cause for the gastrointestinal bleeding. Video capsule endoscopy, however, revealed multiple protruding lesions with slight but continuous oozing throughout the entire small intestine ([Fig. 2 a]); and double-balloon enteroscopy identified protrusions that were covered with normal mucosa with central ulceration and mild bleeding ([Fig. 2 b]). Examination of biopsy specimens showed these protusions to contain tumor cells which ranged in appearance from large polyhedral cells to spindle-shaped cells ([Fig. 3 a]). Immunohistochemical examination revealed tumor cells positive for the mesothelial markers, calretinin and WT1 ([Fig. 3 b]), and the protrusions were diagnosed as metastatic malignant mesothelioma of the small bowel.
606 ANTI-VIRAL THERAPY IN HAEMODIALYZED HCV PATIENTS: EFFICACY, TOLERANCE AND TREATMENT STRATEGY
Authors: P. Deltenre, D. Thabut, A. Tran, C. Moreno, H. Castel, M. El Nady, V. Canva, A. Louvet, H. Ben Ali, F. Provot, F. Glowacki, S. Dharancy, F. Stanke, J. Henrion, C. Noel, P. Mathurin
Journal: Journal of Hepatology (2009)
Recursive reminding and children's concepts of number
Authors: Douglas L. Hintzman
Journal: Behavioral and Brain Sciences (2008)

Abstract According to the recursive reminding hypothesis, repetition interacts with episodic memory to produce memory representations that encode – and recursively embed – experiences of reminding. These representations provide the rememberer with a basis for differentiating among the first time something happens, the second time it happens, and so on. I argue that such representations could mediate children's understanding of natural number.
Measles History and Atopic Diseases
Authors: Mikko Paunio, Olli P. Heinonen, Martti Virtanen, Pauli Leinikki, Annamari Patja, Heikki Peltola
Journal: JAMA (2000)

Many recent cross-sectional studies have suggested that lack of early exposure to communicable diseases, including measles, in affluent countries may have increased rates of atopic disease.To study the association between natural measles infection and atopy.Cross-sectional nationwide study in Finland using data gathered between November 1, 1982, and June 30, 1986.A total of 547910 individuals aged 14 months to 19 years who at the time of measles-mumps-rubella (MMR) vaccination had relevant information collected on the occurrence of measles and allergic rhinitis, eczema, and asthma.Lifetime occurrence of atopic manifestations in subjects who had had measles compared with those who had not, expressed as age-specific and age-adjusted prevalence ratios.The age-adjusted prevalence ratio of atopic manifestations among those who had had measles (n = 20 690) compared with those who had not (n = 527 220) was 1.32 (95% confidence interval [CI], 1.27-1.36) for eczema, 1.41 (95% CI, 1.33-1.49) for rhinitis, and 1.67 (95% CI, 1.54-1.79) for asthma. The positive association between measles and atopy was evident at all ages, in both urban and rural dwellers, and among subjects with many or few contacts at home or in day care.Based on our data, measles and atopy occur more frequently together than expected, which does not support the hypothesis that experiencing natural measles infection offers protection against atopic disease.
Microsporidia Infection in Patients with the Human Immunodeficiency Virus and Unexplained Cholangitis
Authors: Stanislas Pol, Cristina A. Romana, Stephane Richard, Paul Amouyal, Isabelle Desportes-Livage, Francoise Carnot, Jean-Francois Pays, Pierre Berthelot
Journal: New England Journal of Medicine (1993)

Cholangitis in patients with the acquired immunodeficiency syndrome (AIDS) is usually associated with opportunistic infections by cryptosporidium species or cytomegalovirus, but in about a third of cases no opportunistic agent is identified. We suspected some of these cases of biliary disease might be explained by infection with the microsporidia species Enterocytozoon bieneusi, an obligate intracellular protozoan that causes chronic diarrhea in patients infected with the human immunodeficiency virus (HIV).We studied eight HIV-infected homosexual men (in either group IV of the classification of the Centers for Disease Control and Prevention or group II, with a CD4 cell count of < or = 10 per cubic millimeter) who were referred because of cholangitis for which no causative agent had been found by standard tests. All the patients underwent abdominal ultrasonography and endoscopic ultrasonography or endoscopic retrograde cholangiopancreatography with collection of bile from the common bile duct. One patient had transhepatic biliary catheterization, and two others had cholecystectomy. Bile samples, duodenal- and liver-biopsy specimens, and gallbladder tissue were studied by light and electron microscopy.All eight patients with unexplained AIDS-related cholangitis had biliary microsporidosis. Intraepithelial E. bieneusi spores (1 to 2 microns) and supranuclear plasmodia (3 to 8 microns) were identified in the six duodenal-biopsy specimens. May-Grünwald-Giemsa staining of bile samples revealed free forms of microsporidia in all eight patients, and the presence of E. bieneusi was confirmed by electron microscopy. E. bieneusi was also identified in ductal biliary cells on a liver biopsy, in one common-bile-duct smear, and in gallbladder epithelium (in two patients). Four patients were found to have associated but previously undetected biliary or duodenal cryptosporidiosis, whereas another had biliary infection associated with cytomegalovirus.Infection of the biliary tract with E. bieneusi is associated with and may be a cause of AIDS-related cholangitis.
Effectiveness of Diabetic Therapeutic Footwear in Preventing Reulceration
Authors: Matthew L. Maciejewski, Gayle Reiber, Edward J. Boyko
Journal: Diabetes Care (2004)

We thank Chantelau for his thoughtful comments (1) on our study (2), and we recognize his pioneering work on the influence of patient compliance on the effectiveness of diabetic footwear. We characterized his 1990 and 1994 studies (3,4) as descriptive studies of footwear in the text and in Table 3 …