tbuckley/cabot-search huggingface dataset:
Expectations for Recovery Important in the Prognosis of Whiplash Injuries
Authors: Lena W Holm, Linda J Carroll, J. David Cassidy, Eva Skillgate, Anders Ahlbom
Journal: PLoS Medicine (2008)

Individuals' expectations on returning to work after an injury have been shown to predict the duration of time that a person with work-related low back pain will remain on benefits; individuals with lower recovery expectations received benefits for a longer time than those with higher expectations. The role of expectations in recovery from traumatic neck pain, in particular whiplash-associated disorders (WAD), has not been assessed to date to our knowledge. The aim of this study was to investigate if expectations for recovery are a prognostic factor after experiencing a WAD.We used a prospective cohort study composed of insurance claimants in Sweden. The participants were car occupants who filed a neck injury claim (i.e., for WAD) to one of two insurance companies between 15 January 2004 and 12 January 2005 (n = 1,032). Postal questionnaires were completed shortly (average 23 d) after the collision and then again 6 mo later. Expectations for recovery were measured with a numerical rating scale (NRS) at baseline, where 0 corresponds to "unlikely to make a full recovery" and 10 to "very likely to make a full recovery." The scale was reverse coded and trichotomised into NRS 0, 1-4, and 5-10. The main outcome measure was self-perceived disability at 6 mo postinjury, measured with the Pain Disability Index, and categorised into no/low, moderate, and high disability. Multivariable polytomous logistic regression was used for the analysis. There was a dose response relationship between recovery expectations and disability. After controlling for severity of physical and mental symptoms, individuals who stated that they were less likely to make a full recovery (NRS 5-10), were more likely to have a high disability compared to individuals who stated that they were very likely to make a full recovery (odds ratio [OR] 4.2 [95% confidence interval (CI) 2.1 to 8.5]. For the intermediate category (NRS 1-4), the OR was 2.1 (95% CI 1.2 to 3.2). Associations between expectations and disability were also found among individuals with moderate disability.Individuals' expectations for recovery are important in prognosis, even after controlling for symptom severity. Interventions designed to increase patients' expectations may be beneficial and should be examined further in controlled studies.
Cost-effective Sampling of Serum Creatine Kinase in Diagnosis of Acute Myocardial Infarction-Reply
Authors: Michael L. Fisher
Journal: JAMA (1983)

In Reply.—  I thank Dr Steinberg for his remarks and thoughtful reappraisal of our findings. However, the statement that  of SGOT and lactic dehydrogenase  are usually obtained along with those of serum CK levels deserves comment. Although this is still a common practice, the routine use of these additional tests is not appropriate or cost-effective. 1,2 Costs should be calculated by assuming that CK level determinations are routinely required only for the first 24 hours and need not be accompanied by repetitive analysis of  of less specific serum enzymes.
827. Oncogenesis Following Delivery of Lentiviral Vectors to Fetal and Neonatal Mice
Authors: Michael Themis, Simon N. Waddington, Manfred Schmidt, Christof von Kalle, Yoahe Wang, Faisal Al-Allaf, Lisa Gregory, Megha Nivsarkar, Matthew Themis, Maxine Holder, Suzanne M.K. Buckley, Niraja Dighe, Alaine Ruthe, Ajay Mistry, Brian Bigger, Adrian J. Thrasher, Charles Coutelle
Journal: Molecular Therapy (2006)

Gene therapy by use of integrating vectors carrying therapeutic transgene sequences offers the potential for a permanent cure of genetic diseases due to the ability of these vectors to integrate in a stable manner into the patients' chromosomes. Since three cases of T-cell leukaemia have been identified after retrovirus gene therapy for X-linked severe combined immune deficiency as being associated with the integrating vector used for gene therapy the need for animal models to test for vector safety has become of paramount importance. Our previous work has shown that a high frequency of hepatocellular carcinomas has occurred following in utero and neonatal injection with certain lentivirus vectors. It has been hypothesized that the woodchuck post regulatory element (WPRE) carried by the vectors used in this study could be implicated in the tumour development process. Our recent study using novel vectors with mutations in the WPRE shows that mice treated with these vectors still develop liver tumours. In this report we discuss these findings and preliminary data to support an alternative cause for tumorigenesis. We also discuss the fetal and neonatal system as a novel and sensitive in vivo model to test the effects and safety of integrating vectors under consideration for clinical applications.
Back Pain in an Elderly Male Resulting from Gluteal Sarcoma Demonstrated on Skeletal Scintigraphy
Authors: Robert Mansberg, Victor Mansberg, Ron Lawford, Andrew Russon
Journal: Clinical Nuclear Medicine (2005)

Low back pain is an increasingly common problem in our aging population. It is usually related to degenerative spondylosis of the spine. However, unusual causes need to be considered in the differential. An 87-year-old male presented with a several month history of increasing low back pain. Clinical examination followed by plain radiography and CT of the lumbar spine demonstrated minor lumbar spondylosis. A bone scan demonstrated a hypervascular abnormality in the left buttock that on biopsy revealed high grade sarcoma.
Abstract 3081: Tristetraprolin Controls let-7 regulator-Lin28 mRNA stability
Authors: Chae Won Kim, Mai-Tram Vo, Hong Kyeung Kim, Hyo Jeong Kim, Hyun Hee Lee, Nal Ae Yun, Sun Young Lee, Young Joo Min, Jeong Woo Park, Wha Ja Cho
Journal: Cancer Research (2011)

Abstract The RNA binding protein tristetaprolin (TTP) regulates expression of many cancer-associated genes through binding to AU-rich elements (AREs) in the 3’ untranslated region (3’UTR) and facilitating rapid mRNA decay. In this study, we investigated the role of TTP in the control of micro RNA let-7 expression through regulation of Lin28 expression. TTP overexpression significantly suppressed the growth of PA1 human ovarian cancer cell line through down-regulation of CDC34 expression. However, CDC34 does not have the ARE motif within its 3’UTR, suggesting that TTP can not directly regulate CDC34 expression. Instead, CDC34 expression was regulated by let-7. Interestingly, we found that TTP regulates the expression of Lin28 which has been reported to be involved in maturation of let-7. Lin28 mRNA contains two AREs (ARE1 and ARE2) within the 3’UTR, and TTP destabilized a luciferase mRNA containing Lin28 ARE1 and directly bound to the ARE1 of Lin28 mRNA. These studies established Lin28 mRNA as a physiological target of TTP and demonstrate that TTP can control the expression levels of microRNA let-7 through regulation of Lin28 mRNA stability. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3081. doi:10.1158/1538-7445.AM2011-3081
A THEORETICAL NOTE ON THE TOPOLOGICAL FEATURES OF MELANIN TRANSFER
Authors: P. A. Riley
Journal: British Journal of Dermatology (1978)

Journal Article A THEORETICAL NOTE ON THE TOPOLOGICAL FEATURES OF MELANIN TRANSFER Get access P. A. Riley P. A. Riley Department of Biochemical Pathology, University College Hospital Medical School, University Street, WC1E 6JJ Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue 1, 1 July 1978, Pages 107–110, https://doi.org/10.1111/j.1365-2133.1978.tb01968.x Published: 01 July 1978
Evolutionary theory and the riddle of the universe
Authors: Denny Borsboom
Journal: Behavioral and Brain Sciences (2006)

An effective restructuring of the social sciences around the evolutionary model requires that evolutionary theory has explanatory power with respect to the spread of cultural traits: The causal mechanisms involved should be structurally analogous to those of biological evolution. I argue that this is implausible because phenotypical consequences of cultural traits are not causally relevant to their chances of “survival.”
Structural Anomalies in the Cerebellum in Association With Trisomy
Authors: Kornel L. Terplan
Journal: JAMA (1966)

The medical literature on chromosomal aberrations, and their relation to phenotypic abnormalities in outer form and inner organ systems has steadily increased during recent years. In reflecting on the wide spectrum of these abnormal structural changes, and on some recent attempts at their interpretation in terms of specific autosomal deviations, the need for more detailed histological analysis is apparent, in particular with regard to the central nervous system (CNS). Abnormal microscopic findings in organs which appear normal grossly, such as the kidney, pancreas, and adrenal glands have been recently reported in cases of trisomia. 1   It was to be expected that a microscopic study of the CNS by the conventional celloidin technique on large sections would yield findings which might be missed in the smaller sections from paraffin blocks as customarily prepared in the tissue laboratories of pathologists. Whereas such striking anomalies as the absence of olfactory nerves and tracts,
Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells
Authors: Kenji Hyoudou, Makiya Nishikawa, Mai Ikemura, Yuki Kobayashi, Adam Mendelsohn, Nobuhiko Miyazaki, Yasuhiko Tabata, Fumiyoshi Yamashita, Mitsuru Hashida
Journal: Journal of Controlled Release (2007)
Writing left handed
Authors: M G Jacoby
Journal: BMJ (1992)

uses current investment to defray dividends owing to past investors, which can possibly work only in an expanding economy (and is a questionable business practice).This is now being questioned.The famous buck referred to by Heginbotham stopped with Harry Truman, not some anonymous purchaser health authority.Truman did not avoid uncomfortable decisions, even in 1948 when he fought for his political life.It is in this spirit of personal integrity and accountability that the experimental Oregon scheme should be viewed.
339 Steroid administration prior to partial hepatectomy with temporary inflow occlusion does not influence cyclin D1 and Kl-67 related liver regeneration
Authors: M. Glanemann, S. Muenchow, A. Schirmeier, F. Lippek, H. Al-Abadi, J.M. Langrehr, M. Dietel, P. Neuhaus, A.K. Nuessler
Journal: Journal of Hepatology (2004)
Altered myocardial Ca2+cycling after left ventricular assist device support in the failing human heart
Authors: Khuram W. Chaudhary, Eric I. Rossman, Valentino Piacentino, Agnes Kenessey, Chris Weber, John P. Gaughan, Kaie Ojamaa, Irwin Klein, Donald M. Bers, Steven R. Houser, Kenneth B. Margulies
Journal: Journal of the American College of Cardiology (2004)
Plasmablastic lymphoma: One or more entities?
Authors: Antonino Carbone, Annunziata Gloghini
Journal: American Journal of Hematology (2008)

Diffuse large B-cell lymphoma (DLBCL) is the most common type of B-cell lymphoma [1].Morphologic variants of DLBCL mainly include centroblastic, immunoblastic, anaplastic, and T-cell/histiocyte rich lymphomas [1].Plasmablastic lymphoma (PBL) is a rare variant of DLBCL originally described in the oral cavity in the setting of HIV infection [1,2].PBL has subsequently been reported in other sites [1,2].In this issue of the American Journal of Hematology, Castillo et al. [3] present the first extensive literature review of the epidemiology, clinical findings, pathology, treatment, and outcome of 112 patients with HIV-associated PBL.The authors point out that HIV-associated PBL tends to affect young men with CD41 counts less than 200 cells/mm 3 .The consistent presence of plasma cell markers and frequent absence of B-cell markers are key pathologic features of this entity [3].Tumors with plasmablastic differentiation typically occur in patients with an abnormal immune state (HIV positive, posttransplantation, or the elderly).These tumors often arise in the oral cavity or other mucosal sites of the head and neck [1,2], in the body cavity (primary effusion lymphoma -PEL) [4], or in association with multicentric Castleman disease (MCD) [5].In addition, a solid lymphoma/ extracavitary PEL/human herpesvirus 8 (HHV8)-associated DLBCL has been described, predominantly in HIV-positive patients that shows coexpression of Epstein Barr virus (EBV) (Table I) [6,7].All these lymphomas are composed of large cells with abundant cytoplasm and immunoblastic, anaplastic, or plasmacytoid morphology.Irrespective of morphologic type, tumor cells usually express a plasma cell-related phenotypic profile (CD381, MUM11, EMA1/2 CD301/2, CD451/2 (weak), conventional B, and T-cell markers).Morphologically, the PBL of the oral cavity is composed of a very monomorphic, sheet-like proliferation of immunoblasts.The other plasmablastic tumors tend to have a predominance of immunoblasts but show some cells with plasmacytic differentiation.The body cavity and extracavitary PELs have significant nuclear pleomorphism with plasmacytoid morphology in some cells.PBL with plasmacytic differentiation and DLBCL with secretory differentiation (immunoblasts and plasmacytoid cells) are distinguished by the presence of centroblasts in the latter.
Predictors of Long-Term Outcomes in Patients With Significant Myxomatous Mitral Regurgitation Undergoing Exercise Echocardiography
Authors: Peyman Naji, Brian P. Griffin, Fadi Asfahan, Tyler Barr, L. Leonardo Rodriguez, Richard Grimm, Shikhar Agarwal, William J. Stewart, Tomislav Mihaljevic, A. Marc Gillinov, Milind Y. Desai
Journal: Circulation (2014)

Significant myxomatous mitral regurgitation leads to progressive left ventricular (LV) decline, resulting in congestive heart failure and death. Such patients benefit from mitral valve surgery. Exercise echocardiography aids in risk stratification and helps decide surgical timing. We sought to assess predictors of outcomes in such patients undergoing exercise echocardiography.This is an observational study of 884 consecutive patients (age, 58 ± 14 years; 67% men) with grade III+ or greater myxomatous mitral regurgitation who underwent exercise echocardiography between January 2000 and December 2011 (excluding functional mitral regurgitation, prior valvular surgery, hypertrophic cardiomyopathy, rheumatic valvular disease, or greater than mild mitral stenosis). Clinical and echocardiographic data (mitral regurgitation, LV ejection fraction, LV dimensions, right ventricular systolic pressure) and exercise variables (metabolic equivalents, heart rate recovery at 1 minute after exercise) were recorded. Composite events of death, myocardial infarction, stroke, and progression to congestive heart failure were recorded. Mean LV ejection fraction, indexed LV end-systolic dimension, resting right ventricular systolic pressure, peak stress right ventricular systolic pressure, metabolic equivalents achieved, and heart rate recovery were 58 ± 5%, 1.6 ± 0.4 mm/m(2), 31 ± 12 mm Hg, 46 ± 17 mm Hg, 9.6 ± 3, and 33 ± 14 beats, respectively. During 6.4 ± 4 years of follow-up, there were 87 events. On stepwise multivariable Cox analysis, percent of age/sex-predicted metabolic equivalents (hazard ratio, 0.99; 95% confidence interval, 0.98-0.99; P=0.005), heart rate recovery (hazard ratio, 0.29; 95% confidence interval, 0.17-0.50; P<0.001), resting right ventricular systolic pressure (hazard ratio, 1.03; 95% confidence interval, 1.004-1.05; P=0.02), atrial fibrillation (hazard ratio, 1.91; 95% confidence interval, 1.07-3.41; P=0.03), and LV ejection fraction (hazard ratio, 0.96; 95% confidence interval, 0.92-0.99; P=0.04) predicted outcomes.In patients with grade III+ or greater myxomatous mitral regurgitation undergoing exercise echocardiography, lower percent of age/sex-predicted metabolic equivalents, lower heart rate recovery, atrial fibrillation, lower LV ejection fraction, and high resting right ventricular systolic pressure predicted worse outcomes.
Abnormal Systolic Intraventricular Flow Velocities After Valve Replacement for Aortic Stenosis
Authors: Jozef Bartunek, Stanislas U. Sys, Ana Clara Rodrigues, Eddy Van Schuerbeeck, Linda Mortier, Bernard de Bruyne
Journal: Circulation (1996)

Dynamic intraventricular flow velocities after valve replacement for aortic stenosis have been associated with high in-hospital morbidity and mortality. The aims of the present study were to determine the mechanisms and preoperative predictors of abnormal flow velocity (AFV) after valve replacement for aortic stenosis and to assess the clinical course of patients with AFV after surgery.One hundred consecutive patients with pure aortic stenosis were studied prospectively before operation by cardiac catheterization and Doppler echocardiography. After surgery, intraventricular flow was studied by Doppler echocardiography at rest, during nipride infusion, and during dobutamine infusion. AFV (defined as a systolic dagger-shaped Doppler spectrum > 2 m/s) occurred in 14 patients at rest and in 27 patients during nipride and/or dobutamine infusion. In most patients, AFV was associated with left ventricular cavity squeezing. Left ventricular end-diastolic diameter, preoperative intraventricular flow velocity and septal-to-posterior wall thickness ratio by Doppler echocardiography, and mean transvalvular pressure gradient and ejection fraction by catheterization emerged as predictors of resting postoperative AFV. Patients with resting AFV had a higher incidence of dyspnea or hypotension (64% versus 21%, P < .01) and a longer hospital stay (13.1 +/- 5.8 versus 11.1 +/- 2.5, P < .05) than patients without AFV. In contrast, at a 1-year follow-up, no patient with resting AFV died.First, AFV occurs in 14% of patients at rest after valve replacement for aortic stenosis and can be provoked or worsened by ventricular unloading or inotropic stimulation. Second, AFV is related more frequently to cavity squeezing than to systolic anterior motion of the mitral valve apparatus. Third, a typical pattern (small, hyperdynamic, and asymmetrically hypertrophied ventricle) is predictive for postoperative AFV and should be taken into account for the postoperative management. Finally, the presence of AFV at rest is associated with high in-hospital morbidity but good long-term prognosis.
Xeromammography in Early Detection of Breast Cancer
Authors: Lester Kalisher
Journal: JAMA (1975)

Sixty-four carcinomas were detected in 1,315 women examined by xeromammography in 1973. Seventeen carcinomas were occult and 14 were detected in women referred for clinically benign lesions. The remaining 33 carcinomas were diagnosed on the basis of both clinical and roentgenographic examination. There were three false-negatives. Two of these lesions were obscured by very dense fibrocystic disease. The third lesion was called benign due to an error in interpretation. There were eight false-positives; four of these demonstrated intraductal hyperplasia and asymmetry, which may be a precursor to frank malignant change. Xeromammography is suggested as a highly accurate means of detecting occult mammary carcinomas and clarifying the nature of clinically suspected lesions. (<i>JAMA</i>234:60-63, 1975)
Preliminary Imaging Results Using In-111 Labeled CYT-356 (Prostascintst) in the Detection of Recurrent Prostate Cancer
Authors: D. BRUCE SODEE, RIDGELY CONANT, MARSHALL CHALFANT, STEFAN MIRON, ERIC KLEIN, ROBERT BAHNSON, J. PATRICK SPIRNAK, BRUCE CARLIN, ERROL M. BELLON, BARBARA ROGERS
Journal: Clinical Nuclear Medicine (1996)

To evaluate whether In-111 capromab pendetide (an antibody conjugate directed to a glycoprotein found primarily on the cell membrane of prostate tissue) radioimmunoscintigraphy can localize residual or metastatic prostatic carcinoma in 15 patients after prostatectomy and lymphadenectomy for prostatic carcinoma with rising serum prostate-specific antigen. One patient with 0.6 ng/ml serum prostate-specific antigen had normal imaging results and 14 patients had scintigraphic evidence of residual prostatic bed or metastatic prostatic carcinoma. Two patients with borderline abnormal bone scans had abnormal activity in the same regions on In-111 capromab pendetide images. All patients had negative radiographic abdominal and pelvic cross-sectional prestudy images, and there were no adverse effects related to In-111 capromab pendetide infusion and little human antimouse antibody response.
A Mini-Symposium on Acupuncture
Authors: Tsung O. Cheng
Journal: JAMA (1974)

To the Editor.—  Dr. Robert Macintosh (226:1360, 1973) quoted me as being mistaken when I said, The specificity of different points (for needling) is of great importance in acupunctural  ( J Am Geriatr Soc 21:289, 1973).  But, he left out the next sentence in my article, namely, The relative specificities of points reflect the fact that there are certain special connections between different parts of the body. These connections are called meridians or Ching-lo.  Acupunctural anesthesia for thyroidectomy as practiced in the People's Republic of China has been induced by placement of the needles in different points. Unfortunately, Dr. Macintosh failed to appreciate the fact that San-yang-lo referred to in Dimond's article (218:1558, 1971), Fuh-t'u in Gray's article ( Anaesth Intensive Care 1:169, 1972), and Ho-ku in Geiger's article ( World Med Aug 22, 1973, pp 15-23) are not chosen at random but are all interconnected by meridians. These points must be
Effects of atrioventricular interval on left ventricular diastolic filling assessed with pulsed Doppler echocardiography
Authors: T. MASUYAMA, K. KODAMA, S. NAKATANI, A. KITABATAKE
Journal: Cardiovascular Research (1989)

Journal Article Effects of atrioventricular interval on left ventricular diastolic filling assessed with pulsed Doppler echocardiography Get access TOHRU MASUYAMA, TOHRU MASUYAMA a **From the Cardiovascular Division, Osaka Police Hospital, Osaka, Japan aCurrent address: The First Department of Medicine, Osaka University School of Medicine, Osaka, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar KAZUHISA KODAMA, KAZUHISA KODAMA **From the Cardiovascular Division, Osaka Police Hospital, Osaka, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar SATOSHI NAKATANI, SATOSHI NAKATANI **From the Cardiovascular Division, Osaka Police Hospital, Osaka, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar AKIRA KITABATAKE AKIRA KITABATAKE †From The First Department of Medicine, Osaka University School of Medicine, Osaka, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 12, December 1989, Pages 1034–1042, https://doi.org/10.1093/cvr/23.12.1034 Published: 01 December 1989 Article history Accepted: 26 April 1989 Published: 01 December 1989
UK sets out to measure happiness alongside GDP
Authors: N. Hawkes
Journal: BMJ (2010)

The UK government has announced that it is to start measuring the nation’s wellbeing as well as its gross domestic product.

Following the lead of France and the kingdom of Bhutan, the prime minister, David Cameron, announced on 25 November that the national statistical system would start gathering measures of the quality of people’s lives and how contented they felt.

Launching the idea at the Treasury, Mr Cameron said, “It’s high time we admitted that, taken on its own, GDP is an incomplete way of measuring a nation’s progress.”

Denying that the idea was a bit airy fairy and impractical, he said that “just as GDP didn’t give …