tbuckley/cabot-search huggingface dataset:
Thyroid Hemiagenesis Accompanying an Ectopic Sublingual Thyroid
Authors: CHUNG-YUAN HSU, SHYH-JEN WANG
Journal: Clinical Nuclear Medicine (1994)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Online First Collections ACNM MeetingsCMECommunication in OrganizationCOVID-19Feedback and RewardsFrom the American College of Nuclear MedicineHighly Cited and Frequently Read ArticlesPlanning and Conducting Meetings EffectivelyQuality and Safety in Health CareRecruitment of New PhysiciansTips for Giving a Memorable PresentationTips for LeadersTips for Physicians in Getting the Right Job ACNM ArticlesACNM Website For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor PermissionsLippincott&#174; Preprints Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Immunohistochemical analyses of p63 expression in normal human skin
Authors: Y. Takeuchi, A. Tamura, M. Kamiya, K. Suzuki, O. Ishikawa
Journal: British Journal of Dermatology (2004)

Journal Article Immunohistochemical analyses of p63 expression in normal human skin Get access Y. Takeuchi, Y. Takeuchi Departments of Dermatology and Pathology, Graduate School of Medicine, Gunma University, 3‐39‐22 Showa‐machi, Maebashi, Gunma 371‐8511, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Tamura, A. Tamura Departments of Dermatology and Pathology, Graduate School of Medicine, Gunma University, 3‐39‐22 Showa‐machi, Maebashi, Gunma 371‐8511, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Kamiya, M. Kamiya Departments of Dermatology and Pathology, Graduate School of Medicine, Gunma University, 3‐39‐22 Showa‐machi, Maebashi, Gunma 371‐8511, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Suzuki, K. Suzuki Division of Histopathology, Department of Laboratory Sciences, Gunma University School of Health Sciences, Gunma, Japan E‐mail: yukotake@showa.gunma‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar O. Ishikawa O. Ishikawa Departments of Dermatology and Pathology, Graduate School of Medicine, Gunma University, 3‐39‐22 Showa‐machi, Maebashi, Gunma 371‐8511, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 1, 1 July 2004, Pages 232–235, https://doi.org/10.1111/j.1365-2133.2004.06023.x Published: 01 July 2004
Rapid differentiation of bacterial meningitides by direct gas-liquid chromatography.
Authors: H Thadepalli, P K Gangopadhyay, A Ansari, G D Overturf, V K Dhawan, A K Mandal
Journal: Journal of Clinical Investigation (1982)

Rapid identification of Haemophilus influenzae and other bacillary meningitides was attempted by gas-liquid chromatography (GLC) of the metabolic by-products in broth cultures and in cerebrospinal fluid (CSF) samples obtained from experimental meningitis produced in New Zealand White male rabbits. These results were correlated with the GLC of CSF of meningitis patients. A major peak with retention time of succinic acid was found in the broth cultures of all bacilli tested including H. influenzae, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, Proteus mirabilis, Citrobacter freundii, Pseudomonas aeruginosa, and Listeria monocytogenes. Succinic acid was also found in the CSF of experimental meningitis and in the CSF of all patients with H. influenzae and Esch. coli meningitis. This peak was not detected in the blood samples of experimental animals. It was also absent in the broth cultures of all of the gram-positive and gram-negative cocci tested, such as Streptococcus pneumoniae and Neisseria meningitidis. Succinic acid, which appears to be a by product of fermentation, persisted as a clear cut marker in H. influenzae meningitis for at least 3 d after the initiation of treatment. In one patient, the succinic acid peak disappeared during treatment and reappeared with a clinical relapse. Clearly, the presence of succinic acid that can be rapidly detected by GLC in the CSF excludes pneumococcal or meningococcal meningitis and strongly suggests H. influenzae or other bacillary meningitides.
Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.
Authors: S Anderson, T W Meyer, H G Rennke, B M Brenner
Journal: Journal of Clinical Investigation (1985)

Micropuncture and morphologic studies were performed in four groups of male Munich-Wistar rats after removal of the right kidney and segmental infarction of two-thirds of the left kidney. Groups 1 and 3 received no specific therapy. Groups 2 and 4 were treated with the angiotensin I converting enzyme inhibitor, enalapril, 50 mg/liter of which was put in their drinking water. All rats were fed standard chow. Groups 1 and 2 underwent micropuncture study 4 wk after renal ablation. Untreated group 1 rats exhibited systemic hypertension and elevation of the single nephron glomerular filtration rate (SNGFR) due to high average values for the mean glomerular transcapillary hydraulic pressure difference and glomerular plasma flow rate. In group 2 rats, treatment with enalapril prevented systemic hypertension and maintained the mean glomerular transcapillary hydraulic pressure gradient at near-normal levels without significantly compromising SNGFR and the glomerular capillary plasma flow rate, as compared with untreated group 1 rats. Groups 3 and 4 were studied 8 wk after renal ablation. Untreated group 3 rats demonstrated persistent systemic hypertension, progressive proteinuria, and glomerular structural lesions, including mesangial expansion and segmental sclerosis. In group 4 rats, treatment with enalapril maintained systemic blood pressure at normal levels over the 8-wk period and significantly limited the development of proteinuria and glomerular lesions. These studies suggest that control of glomerular hypertension effectively limits glomerular injury in rats with renal ablation, and further support the view that glomerular hemodynamic changes mediate progressive renal injury when nephron number is reduced.
Detection of renal anomalies by abdominal palpation in newborn infants.
Authors: M Perlman, J Williams
Journal: BMJ (1976)

In a new technique of palpation for renal anomalies in the newborn one hand supports the infant while the fingers of the other hand support the loin and the thumb explores the abdomen. In a series of 11 000 otherwise normal newborn children superficial palpation detected 11 renal anomalies, and deep palpation led to the discovery of another 42 anomalies. One of two other series in which palpation was performed bimanually gave a similar incidence of renal anomalies (0-5%). Early discovery of an asymptomatic anomaly enables early treatment of the complications that are often found in patients with congenital renal anomalies detected in later life.
The Law, Public Policy, and the Peddlers of Tobacco-Reply
Authors: Paul D. Cleary
Journal: JAMA (1992)

<h3>In Reply.</h3> —Each of the above letters supports stronger governmental regulation of tobacco manufacturers and sellers. Dr Priver, however, rejects indirect regulation through the tort system because smokers should not be permitted to shift responsibility for their own health decisions to tobacco companies. Certainly, individuals should heed public health advice and government warnings to stop smoking. But if smokers can demonstrate that cigarette manufacturers knowingly concealed information they had in their possession about the dangers of smoking or intentionally mislead consumers, why should the law shield producers from their responsibilities and potential liability? As we state in our article, the worst outcome of the<i>Cipollone</i>case would be to grant cigarette companies preferred status when all other manufacturers still had to defend the safety of their products and the adequacy of their warnings in the court system. In January, the Supreme Court heard oral arguments in the<i>Cipollone</i>case for
H2 receptor blockade and bronchial hyperreactivity to histamine in asthma.
Authors: S G Nogrady, C Bevan
Journal: Thorax (1981)

The role of histamine H1 and H2 receptors in the lung is not clear. H1 receptor blockade results in bronchodilatation and inhibition of histamine induced bronchoconstriction. H2 receptor blockade in vitro prevents the normal negative feedback of histamine on further mediator release in antigen challenge. Bronchospasm in guinea pigs given antigen challenge is enhanced by previous administration of metiamide or burimamide but not of cimetidine. These findings suggest the possible deleterious effect of H2 receptor antagonists in asthmatic subjects. The effects of H2 receptor blockade with cimetidine on bronchial hyperreactivity to histamine were studied in 10 asthmatic volunteers by whole body plethysmography. Cimetidine 800 mg and placebo were administered orally on two separate days, eight hours and two hours before study. No significant difference in baseline levels of airways obstruction was seen with the two agents. Inhalational challenge with increasing concentrations of histamine revealed no significant difference in bronchial hyperreactivity to histamine between cimetidine and placebo treatment days. H2 receptor blockade with cimetidine does not appear to affect ventilatory function or bronchial hyperreactivity to histamine in asthmatic subjects. It has been suggested that cimetidine may have H1 as well as H2 receptor blocking properties which prevent this effect.
Airway muscle stereology: implications for increased shortening in asthma.
Authors: R J Thomson, A M Bramley, R R Schellenberg
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Increased airway smooth muscle, resulting from either hyperplasia or hypertrophy, has been implicated as a cause of excessive bronchoconstriction in asthma despite the many methodologic limitations of studies to date. Our recent failure to demonstrate increased muscle volume in an asthmatic airway preparation having 3-fold greater shortening than nonasthmatic controls prompted us to reassess the quantity of muscle in asthmatic versus nonasthmatic airways. Smooth muscle was quantified in axially sectioned, 2nd- to 4th-generation bronchi, using standardized stereologic methods on high-magnification images of cross-sectional airway smooth muscle profiles in tissues from five asthmatic subjects and five nonasthmatic smokers. When data were normalized by total cross-sectional tissue area, no differences between the two groups (asthmatic versus nonasthmatic) were detected for the proportion of smooth muscle (3.45 +/- 0.81% versus 2.74 +/- 0.76%), extracellular matrix between muscle cells (1.65 +/- 0.46% versus 1.06 +/- 0.25%), or connective tissue within smooth muscle bundles (1.65 +/- 0.34% versus 1.53 +/- 0.59%). These methodologies for evaluating cross-sectional airway muscle in axial airway sections at high resolution provide no evidence of increased airway smooth muscle in asthmatic large airways, and suggest that differences in mechanical responses of asthmatic airways cannot be explained solely by the amount of smooth muscle.
Oncolytic Measles Virus Expressing the Sodium Iodide Symporter to Treat Drug-Resistant Ovarian Cancer
Authors: Evanthia Galanis, Pamela J. Atherton, Matthew J. Maurer, Keith L. Knutson, Sean C. Dowdy, William A. Cliby, Paul Haluska, Harry J. Long, Ann Oberg, Ileana Aderca, Matthew S. Block, Jamie Bakkum-Gamez, Mark J. Federspiel, Stephen J. Russell, Kimberly R. Kalli, Gary Keeney, Kah Whye Peng, Lynn C. Hartmann
Journal: Cancer Research (2014)

Edmonston vaccine strains of measles virus (MV) have significant antitumor activity in mouse xenograft models of ovarian cancer. MV engineered to express the sodium iodide symporter gene (MV-NIS) facilitates localization of viral gene expression and offers a tool for tumor radiovirotherapy. Here, we report results from a clinical evaluation of MV-NIS in patients with taxol- and platinum-resistant ovarian cancer. MV-NIS was given intraperitoneally every 4 weeks for up to 6 cycles. Treatment was well tolerated and associated with promising median overall survival in these patients with heavily pretreated ovarian cancer; no dose-limiting toxicity was observed in 16 patients treated at high-dose levels (10(8)-10(9) TCID50), and their median overall survival of 26.5 months compared favorably with other contemporary series. MV receptor CD46 and nectin-4 expression was confirmed by immunohistochemistry in patient tumors. Sodium iodide symporter expression in patient tumors after treatment was confirmed in three patients by (123)I uptake on SPECT/CTs and was associated with long progression-free survival. Immune monitoring posttreatment showed an increase in effector T cells recognizing the tumor antigens IGFBP2 and FRα, indicating that MV-NIS treatment triggered cellular immunity against the patients' tumor and suggesting that an immune mechanism mediating the observed antitumor effect. Our findings support further clinical evaluation of MV-NIS as an effective immunovirotherapy.
Federal Trade Commission Order
Authors: Carol M. Thomas
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Services for Hospital Employees
Authors: Lemuel C. McGee
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The editorial emphasis (<i>JAMA</i><b>190</b>:1065 [Dec 21] 1964) given to the paper by Mammen, H.W. "The Need for Employee Health Services in Hospitals" (<i>Arch Environ Health</i><b>9</b>:750 [Dec] 1964) is a timely one. His experience in occupational health and industrial hygiene gives Mammen a splendid foundation for an impressive survey of the working environment in an unnamed (understandably!) hospital of 647 beds plus 59 bassinets. The number of employees for the biennial period of the survey averaged 1,740; excluding residents, interns, and student nurses. There were nine identifiable hazards to health, six obvious accident risks, and a variety of sanitation laxities. During the biennium there were 665 injuries; 71 were lost-time accidents (threefold the ratio in industry as a whole). The lack of adequate occupational health services for hospital employees is one which should be a source of embarrassment to hospital management and professional staff
New Directions in the Evaluation and Education of Handicapped Children
Authors: Judith S. Palfrey, Richard C. Mervis, John A. Butler
Journal: New England Journal of Medicine (1978)

The Education for All Handicapped Children Act of 1975, which went into effect last October, ensures the right of handicapped children to free appropriate public education. State and local education agencies are required to identify, evaluate and provide services for all disabled children. This multibilliondollar program will guarantee special education resources for up to 12 per cent of American children. A role for physicians in the program is implied rather than defined in the law. Their involvement will vary somewhat from state to state, but will at a minimum involve counseling parents whose children are under evaluation. The law assumes a sophistication of diagnostic ability and curriculum design that does not yet exist, and therefore places a special burden upon physicians to deal effectively with patients now, while developing better training programs and assessment tools, and makes essential the enhancement of the communication between doctors and educators.
Comparative Evaluation of Technetium-99m Glucoheptonate and Gallium-67 Citrate Thoracic Imaging in Detection of Mediastinal and Hilar Involvement in Primary Lung Cancer
Authors: RAYMOND TAILLEFER, GILLES BEAUCHAMP, JEAN L??VEILL??
Journal: Clinical Nuclear Medicine (1986)

Fifty-two patients with proven primary lung cancer who were referred for mediastinoscopy were prospectively studied with Tc-99m glucoheptonate and Ga-67 citrate thoracic scintigraphy. Primary lung tumors concentrated Ga-67 in 92% of cases, compared to 88% for Tc-99m glucoheptonate. Mediastinoscopy confirmed the presence of mediastinal metastases in 23 patients. The sensitivity of Tc-99m glucoheptonate and Ga-67 scans for mediastinal involvement detection is respectively 52% and 83%, for a specificity of 100% (Tc-99m glucoheptonate) and 88% (Ga-67). Twenty-nine patients underwent thoracotomy after a negative mediastinoscopy. Hilar metastatic involvement was present in eight patients. The sensitivity and the specificity for detection of hilar involvement were respectively 63% and 95% for Tc-99m glucoheptonate and 88% and 78% for Ga-67. Although more specific than Ga-67 scan, Tc-99m glucoheptonate thoracic imaging cannot be recommended in the staging of lung cancer because of its low sensitivity in the detection of intrathoracic metastatic spread of primary lung carcinoma.
Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway
Authors: Pappachan E. Kolattukudy, Jianli Niu
Journal: Circulation Research (2012)

Numerous inflammatory cytokines have been implicated in the pathogenesis of cardiovascular diseases. Monocyte chemoattractant protein (MCP)-1/CCL2 is expressed by mainly inflammatory cells and stromal cells such as endothelial cells, and its expression is upregulated after proinflammatory stimuli and tissue injury. MCP-1 can function as a traditional chemotactic cytokine and also regulates gene transcription. The recently discovered novel zinc-finger protein, called MCPIP (MCP-1-induced protein), initiates a series of signaling events that causes oxidative and endoplasmic reticulum (ER) stress, leading to autophagy that can result in cell death or differentiation, depending on the cellular context. After a brief review of the basic processes involved in inflammation, ER stress, and autophagy, the recently elucidated role of MCP-1 and MCPIP in inflammatory diseases is reviewed. MCPIP was found to be able to control inflammatory response by inhibition of nuclear factor-κB activation through its deubiquitinase activity or by degradation of mRNA encoding a set of inflammatory cytokines through its RNase activity. The potential inclusion of such a novel deubiquitinase in the emerging anti-inflammatory strategies for the treatment of inflammation-related diseases such as cardiovascular diseases and type 2 diabetes is briefly discussed.
How to induce ovarian cancer: and how not to.
Authors: J S Scott
Journal: BMJ (1984)

It has been hypothesized that pregnancy and oral contraceptives (OCs) exert a protective effect on the risk of ovarian cancer through the suppression of ovulation.  Even short periods of OC use have been associated with about a 40% reduction in the incidence of ovarian cancer.  There has also been renewed interest in the role of gonadotropins in producing ovarian cancer.  However ovarian cancer plateaus after menopause at which time there are sustained high concentrations of gonadotropins.  Cyclic gonadotropins have an essential role in the monthly production of steroids and research in this area is expected to increase understanding of how ovulation seems to affect the incidence of ovarian cancer.  Although 1 study suggesting that pregnancy has a permanent effect on the pituitary secretion of trophic hormones was based on tenuous anatomical grounds some semipermanent resetting of a homeostatic control mechanism does appear to be involved.  The differences in the backgrounds of ovarian and breast cancer are thought to be attributable to differing hormone sensitivities in the tissues involved.
Intercellular adhesion molecule-1 is upregulated on peripheral blood T lymphocyte subsets in dual asthmatic responders.
Authors: V De Rose, G Rolla, C Bucca, P Ghio, M Bertoletti, P Baderna, E Pozzi
Journal: Journal of Clinical Investigation (1994)

To examine the role of adhesion molecules in T cell recruitment and activation during allergen-induced late asthmatic response (LAR), we evaluated the expression of lymphocyte function-associated antigen-1 alpha (LFA-1 alpha) and intercellular adhesion molecule-1 (ICAM-1) on peripheral blood T lymphocyte subsets from atopic asthmatic patients and their changes following allergen inhalation challenge. 12 atopic asthmatic patients were studied. Six patients showed only a single early response after allergen challenge, and six developed a dual response. At baseline, dual responders (DR) had a significantly higher expression of ICAM-1 on CD4+ and CD8+ T lymphocytes as compared with both single early responders (P < 0.005 and P < 0.02, respectively) and controls (P < 0.001, both comparisons). Allergen challenge was followed by a decrease of CD8+ ICAM-1+ T lymphocytes in all DR (P < 0.05) and of CD4+ ICAM-1+ T lymphocytes in four out of six DR, at the time of the LAR. At the same time, a significant rise in serum levels of the soluble form of ICAM-1 was observed in DR. These results suggest that peripheral blood immunoregulatory T lymphocytes are in a higher state of activation in DR as compared with early responders. The upregulation of ICAM-1 on these cells may be important in enhancing airway inflammation in patients with LAR.