Ocular Amyloid Involvement after Liver Transplantation for Polyneuropathy
Authors: Eiko Ando, Yukio Ando, Katsuki Haraoka
Journal: Annals of Internal Medicine (2001)

Letters20 November 2001Ocular Amyloid Involvement after Liver Transplantation for PolyneuropathyEiko Ando, MD, Yukio Ando, MD, and Katsuki Haraoka, MDEiko Ando, MDKumamoto National Hospital; Kumamoto 860-0008, Japan (Ando, Ando, Haraoka)Kumamoto University School of Medicine; Kumamoto 860-0811, Japan, Yukio Ando, MDKumamoto National Hospital; Kumamoto 860-0008, Japan (Ando, Ando, Haraoka)Kumamoto University School of Medicine; Kumamoto 860-0811, Japan, and Katsuki Haraoka, MDKumamoto National Hospital; Kumamoto 860-0008, Japan (Ando, Ando, Haraoka)Kumamoto University School of Medicine; Kumamoto 860-0811, JapanAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-10-200111200-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Liver transplantation has been performed for familial amyloidotic polyneuropathy (FAP) since 1990 (1) because amyloidogenic transthyretin (ATTR), the pathogenic protein of FAP, is predominantly synthesized by the liver. Liver transplantation is now considered a promising life-saving therapy for patients with FAP (2–4). After liver transplantation, variant serum transthyretin levels have decreased to less than 1% of those before the procedure, and clinical findings have improved or have not deteriorated. However, the role of transthyretin synthesized by the choroid plexus of the brain and the retina (5) in patients with FAP remains to be elucidated. Since ocular manifestations ...References1. Holmgren G, Ericzon BG, Groth CG, Steen L, Suhr O, Andersen O, et al . Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis. Lancet. 1993;341:1113-6. [PMID: 8097803] CrossrefMedlineGoogle Scholar2. Skinner M, Lewis WD, Jones LA, Kasirsky J, Kane K, Ju ST, et al . Liver transplantation as a treatment for familial amyloidotic polyneuropathy. Ann Intern Med. 1994;120:133-4. [PMID: 8256972] LinkGoogle Scholar3. Ando Y, Gotoh T, Kawaguchi Y, Tanaka Y, Sakashita N, Ando M. Intranasal L-threo-3,4,-dihydroxyphenylserine in treating diarrhea associated with familial amyloidotic polyneuropathy. Pharmacotherapy. 1995;15:345-9. [PMID: 7667168] MedlineGoogle Scholar4. Suhr O, Danielsson A, Rydh A, Nyhlin N, Hietala SO, Steen L. Impact of gastrointestinal dysfunction on survival after liver transplantation for familial amyloidotic polyneuropathy. Dig Dis Sci. 1996;41:1909-14. [PMID: 8888700] CrossrefMedlineGoogle Scholar5. Cavallaro T, Martone RL, Dwork AJ, Schon EA, Herbert J. The retinal pigment epithelium is the unique site of transthyretin synthesis in the rat eye. Invest Ophthalmol Vis Sci. 1990;31:497-501. [PMID: 1690688] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Eiko Ando, MD; Yukio Ando, MD; Katsuki Haraoka, MDAffiliations: Kumamoto National Hospital; Kumamoto 860-0008, Japan (Ando, Ando, Haraoka)Kumamoto University School of Medicine; Kumamoto 860-0811, Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin AmyloidogenesisOcular Involvement in Hereditary AmyloidosisModulation of the Mechanisms Driving Transthyretin AmyloidosisDiagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithmTowards targets and treatments in transthyretin amyloidosisMarked biochemical difference in amyloid proportion between intra- and extraocular tissues in a liver-transplanted patient with hereditary ATTR amyloidosisBiochemical characterization of vitreous amyloid formed after liver transplantationImpact of liver transplantation on the natural history of oculopathy in Portuguese patients with transthyretin (V30M) amyloidosisMacular and optic disc edema and retinal vascular leakage in familial amyloid polyneuropathy with a transthyretin Val30Met mutation: a case reportBeyond Genetic Factors in Familial Amyloidotic Polyneuropathy: Protein Glycation and the Loss of Fibrinogen's Chaperone ActivityAnticipation of presbyopia in Portuguese familial amyloidosis ATTR V30MRECURRENCE OF VITREOUS AMYLOIDOSIS AND NEED OF SURGICAL REINTERVENTION IN PORTUGUESE PATIENTS WITH FAMILIAL AMYLOIDOSIS ATTR V30MNovel Therapy for Transthyretin–related Ocular AmyloidosisPenetrance estimation of TTR familial amyloid polyneuropathy (type I) in Brazilian familiesNew Therapeutic Approaches for Familial Amyloidotic Polyneuropathy (FAP)Immunization in familial amyloidotic polyneuropathy: counteracting deposition by immunization with a Y78F TTR mutantAging and transthyretin-related amyloidosis: Pathologic examinations in pulmonary amyloidosisBiochemical characterization of vitreous and cardiac amyloid in Ile84Ser transthyretin amyloidosisLiver transplantation treatment of familial amyloidosis.Ocular Amyloid Angiopathy Associated with Familial Amyloidotic Polyneuropathy Caused by Amyloidogenic Transthyretin Y114CLiver transplantation and new therapeutic approaches for familial amyloidotic polyneuropathy (FAP)Transthyretin synthesis in rabbit ciliary pigment epitheliumApplications of gene therapy for familial amyloidotic polyneuropathyNew therapeutic approaches for familial amyloidotic polyneuropathy (FAP)Presence of variant transthyretin in aqueous humor of a patient with familial amyloidotic polyneuropathy after liver transplantationAmyloid deposition in ocular tissues of patients with familial amyloidotic polyneuropathy (FAP) 20 November 2001Volume 135, Issue 10 Page: 931-932 Keywords Glaucoma Hypotension Intraocular pressure Liver diseases Liver transplantation Methionine Orthotopic liver transplantation Pathogens Retina Retinal vessels ePublished: 20 November 2001 Issue Published: 20 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...