The Clinical Significance of Deoxyribonucleic Acid Particles in Synovial Fluid
Authors: Thomas J. Pekin, Theodore I. Malinin, Nathan J. Zvaifler
Journal: Annals of Internal Medicine (1966)

Article1 December 1966The Clinical Significance of Deoxyribonucleic Acid Particles in Synovial FluidTHOMAS J. PEKIN JR., M.D., THEODORE I. MALININ, M.D., NATHAN J. ZVAIFLER, M.D.THOMAS J. PEKIN JR., M.D.Search for more papers by this author, THEODORE I. MALININ, M.D.Search for more papers by this author, NATHAN J. ZVAIFLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1229 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExamination of synovial fluid has proved to be of definite value in the diagnosis of certain rheumatic conditions; but more importantly, it has led to greater understanding of the pathogenesis of some diseases affecting joints.Renewed interest in the study of synovial fluid has been stimulated by the identification of sodium urate crystals in the synovial fluids of patients with gouty arthritis (1, 2) and has resulted in an understanding of the role of urate crystals in acute gouty inflammation (3). The finding of calcium pyrophosphate crystals in the synovial fluid of patients with pseudogout (4) has provided a rapid...References1. MCCARTYHOLLANDER DJJL: Identification of urate crystals in gouty synovial fluid. Ann. 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Activity in serum and synovial fluid. Arthritis Rheum. 8: 219, 1965. CrossrefMedlineGoogle Scholar8. HOLLANDERMCCARTYASTORGACASTRO-MURILLO JLDJGE: Studies on the pathogenesis of rheumatoid joint inflammation. I. The "R. A. cell" and a working hypothesis. Ann. Intern. Med. 62: 271, 1965. LinkGoogle Scholar9. ASTORGABOLLET GAJ: Diagnostic specificity and possible pathogenetic significance of inclusions in synovial leucocytes. Arthritis Rheum. 8: 511, 1965. CrossrefMedlineGoogle Scholar10. MALININPEKINZVAIFLERBAUER TITJNJH: Vacuoles in synovial fluid leukocytes. Amer. J. Clin. Path. 45: 728, 1966. CrossrefMedlineGoogle Scholar11. MALININPEKINZVAIFLER TITJNJ: Cytology of rheumatoid synovial fluids. Amer. J. Clin. Path. In press, 1967. CrossrefMedlineGoogle Scholar12. ROPESBENNETTCOBBJACOXJESSAR MWGASRRA: 1958 revision of diagnostic criteria for rheumatoid arthritis. Bull. Rheum. Dis. 9: 175, 1958. MedlineGoogle Scholar13. ROPESBAUER MWW: Synovial Fluid Changes in Joint Disease. Harvard University Press, Cambridge, 1953. Google Scholar14. BLOCHBUNIM KJJJ: Simple, rapid and diagnostic test for rheumatoid arthritis—bentonite flocculation test. JAMA 169: 307, 1959. CrossrefMedlineGoogle Scholar15. Arthritis and Allied Conditions, 6th ed., edited by HOLLANDER, J. L. Lea & Febiger, Philadelphia, 1960, pp. 257, 271. Google Scholar16. TANSCHURKUNKEL EMPHHG: DNA in the serum of patients with systemic lupus erythematosus (abstract). J. Clin. Invest. 44: 1165, 1965. Google Scholar17. BERTINOHOLLINGSWORTHCASHMORE JRJWAR: Granulocyte kinetics in rheumatoid effusions studied by a biochemical label. Trans. Ass. Amer. Physicians 76: 63, 1963. Google Scholar18. BARNETTBIENENSTOCKBLOCH EVJKJ: Antinuclear factors in synovial fluid: possible participants in the rheumatoid inclusion body (abstract). Arthritis Rheum. 7: 726, 1964. Google Scholar19. ZVAIFLER NJ: A speculation on the pathogenesis of joint inflammation in rheumatoid arthritis. Arthritis Rheum. 8: 289, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.From the Departments of Medicine and Research Pathology, Georgetown University Schools of Medicine and Dentistry, Washington, D. C.This study was supported by grants AM 5140 and AM 5042, U. S. Public Health Service, Washington, D. C., and by the Arthritis Foundation of Metropolitan Washington, Washington, D. C.Requests for reprints should be addressed to Thomas J. Pekin, Jr., M.D., Division of Rheumatic Diseases, Department of Medicine, Georgetown University Medical Center, Washington, D. C. 20007. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGranulocyte-Specific Antinuclear Antibodies.Synovial FluidAntinuclear antibodies (ANA): Immunologic and clinical significanceReduction of pleural fluid complement activity in patients with systemic lupus erythematosus and rheumatoid arthritisThe Immunopathology of Joint Inflammation in Rheumatoid ArthritisIn Vivo LE Cell Formation in Synovial FluidRole of nuclear antigens and antinuclear antibodies in inflammation 1 December 1966Volume 65, Issue 6Page: 1229-1236KeywordsArthritisMedical servicesPathogenesisProteinsPsoriasisRheumatic conditionsRheumatic feverSynovial fluidUlcerative colitisUric acid Issue Published: 1 December 1966 PDF DownloadLoading ...