tbuckley/cabot-search huggingface dataset:
766 NEUTRAL ENDOPEPTIDASE (EC 3.4.24.11) INHIBITION BLUNTS ENDOTHELIN-1 PRODUCTION IN CIRRHOTIC RAT LIVERS: PHYSIOPATHOLOGICAL IMPLICATIONS
Authors: G. Sansoe', M. Aragno, F. Rosina, A. Smedile, M. Rizzetto, M. Parola
Journal: Journal of Hepatology (2009)
"Capillary Permeability" in Patients with Collagen Vascular Diseases
Authors: J. Marks, D. A. Birkett, S. Shuster
Journal: BMJ (1972)

"Capillary permeability" to serum albumin has been measured in patients with collagen vascular diseases by a method which compares the dilution of intravenously injected (131)I-human serum albumin and (51)Cr-R.B.C.s. The results indicate an increased capillary permeability comparable to that which occurs in patients with extensive inflammatory skin disease. We suggest that this increased capillary permeability may be the cause of the episodes of oedema which occur in patients with collagen vascular diseases such as disseminated lupus erythematosus, systemic sclerosis, dermatomyositis, polyarteritis nodosa, and rheumatoid arthritis. "Spontaneous periodic oedema" may be the presenting feature of collagen vascular disease and is due to increased capillary permeability.
Adult Education: For the Academic Clinical Teacher
Authors: J. McMichael
Journal: BMJ (1955)

A schoolteacher once said to me: " I don't know how you doctors keep it up, I've forgotten all I learnt at the university."The answer is simple: continuing experience in the clinical field and responsibi'ity for vital decisions compel the conscientious doctor to strive to keep abreast.The system in this country of frequent reference by family doctors to trained specialist consultants is really a continuation of clinical teaching for the general practitioner, who can thus maintain an awareness of the modern practical outlook on the problems of the patients for whom he is responsible: personal contact with, and letters and reports from, his local or central consultant hospital staff are continuously available for instruction and interchange of new ideas.Experience at the Posgraduate School How do our consultants themselves keep up to date ?The methods are: (1) by team-work, (2) by external contacts,
Synchronous Pure Epithelioid Angiomyolipoma of the Kidney and Retroperitoneal Schwannoma in the Same Patient on 18F-FDG PET/CT Imaging
Authors: Aisheng Dong, Yang Wang, Changjing Zuo
Journal: Clinical Nuclear Medicine (2013)

A 21-year-old woman was admitted to our hospital after incidental detection of a left renal lesion on ultrasound scan. Abdominal contrast-enhanced CT scan revealed a moderately enhanced lesion in the left kidney and a round mass with slight enhancement in the retroperitoneum. FDG PET/CT imaging was performed for whole-body survey, showing increased tracer accumulation in both the left renal and the retroperitoneal lesions. Left renal cell carcinoma with retroperitoneal metastasis was suspected. Synchronous pure epithelioid angiomyolipoma of the left kidney and retroperitoneal schwannoma were diagnosed by pathology. This case highlights that epithelioid angiomyolipoma should be considered as one of the differential diagnosis in renal lesions with increased FDG uptake.
Treatment of Typhoid Fever.—An Answer.
Authors: B. M. Smith
Journal: JAMA (1897)

Davis, W. Va., Aug. 3, 1897. <h3>To the Editor:</h3> —In theJournalof July 10 I notice an article on the "Treatment of Typhoid Fever," by Dr. Upshur of Richmond, Va., and his criticism of Dr. Woodbridge. His treatment especially attracted my attention. He says: "Dr. W. makes claims of such brilliant results that one is startled, and the question arises, have I been groping and blundering all these years?" In the outset he desires it understood that he has never used it, not because of any<i>spirit of prejudice or unfairness</i>, but because upon careful consideration the brilliant results<i>claimed</i>, to his mind, disproved the facts, and he did not feel willing to trifle with the lives of his patients by uncertain experiments. He has never tried it. How can we know of anything unless we try it? How does the Doctor do when he hears of a new
Pulmonary Embolization and Oral Contraceptive
Authors: John N. Ferguson
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I would like to report a case of pulmonary embolization with a fatal outcome that I feel may have been associated with the use of norethynodrel with mestranol for more than a year. <h3>Report of a Case:—</h3> The patient was 21 years old and had started taking norethynodrel with mestranol (Enovid-E) approximately 11/2 years previously. I first saw her in November 1965 with recurrent cystitis. An intravenous pyelogram ruled out the possibility of a congenital urinary tract malformation, and the urinary tract infection subsided on treatment with sulfonamides. On Oct 3. 1966, she had a cramp in her left leg upon arising in the morning and felt somewhat breathless. She went to work and I advised that she return home. The pain in the leg subsided. Two or three days later she had additional pain in the leg and some pain in the lateral aspect of the
THE GLANDS OF MONTGOMERY
Authors: WILLIAM MONTAGNA, JEUNG SOON YUN
Journal: British Journal of Dermatology (1972)

Journal Article THE GLANDS OF MONTGOMERY Get access WILLIAM MONTAGNA, WILLIAM MONTAGNA Oregon Regional Primate Research Centre, 505 N.W. 185th Avenue, Beaverton, Oregon, 97005, U.S.A., and University of Oregon Medical School, Portland, 97201, U.S.A Search for other works by this author on: Oxford Academic Google Scholar JEUNG SOON YUN JEUNG SOON YUN Oregon Regional Primate Research Centre, 505 N.W. 185th Avenue, Beaverton, Oregon, 97005, U.S.A., and University of Oregon Medical School, Portland, 97201, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 2, 1 February 1972, Pages 126–133, https://doi.org/10.1111/j.1365-2133.1972.tb16074.x Published: 01 February 1972 Article history Accepted: 12 October 1971 Published: 01 February 1972
Immediate intraportal transplantation of human bone marrow mesenchymal stem cells prevents death from fulminant hepatic failure in pigs
Authors: Jun Li, Liyuan Zhang, Jiaojiao Xin, Longyan Jiang, Jun Li, Ting Zhang, Linfeng Jin, Jianzhou Li, Pengcheng Zhou, Shaorui Hao, Hongcui Cao, Lanjuan Li
Journal: Hepatology (2012)

The effectiveness of human bone marrow mesenchymal stem cell (hBMSC) transplantation to treat acute and chronic liver injury has been demonstrated in animal models and in a few nonrandomized clinical trials. However, no studies have investigated hBMSC transplantation in the treatment of fulminant hepatic failure (FHF), especially in large animal (pig) models. The aim of this study was to demonstrate the safety, effectiveness, and underlying mechanism of hBMSC transplantation for treating FHF in pigs through the intraportal route. Human BMSCs (3 × 10(7) ) were transplanted into pigs with FHF via the intraportal route or peripheral vein immediately after D-galactosamine injection, and a sham group underwent intraportal transplantation (IPT) without cells (IPT, peripheral vein transplantation [PVT], and control groups, respectively, n = 15 per group). All of the animals in the PVT and control groups died of FHF within 96 hours. In contrast, 13 of 15 animals in the IPT group achieved long-term survival (>6 months). Immunohistochemistry demonstrated that transplanted hBMSC-derived hepatocytes in surviving animals were widely distributed in the hepatic lobules and the liver parenchyma from weeks 2 to 10. Thirty percent of the hepatocytes were hBMSC-derived. However, the number of transplanted cells decreased significantly at week 15. Only a few single cells were scattered in the regenerated liver lobules at week 20, and the liver tissues exhibited a nearly normal structure. Immediate IPT of hBMSCs is a safe and effective treatment for FHF. The transplanted hBMSCs may quickly participate in liver regeneration via proliferation and transdifferentiation into hepatocytes during the initial stage of FHF. This method can possibly be used in future clinical therapy.
Steatorrihoea and Glossitis after Ileocolostomy
Authors: A. Brown
Journal: BMJ (1949)

MEDICSLHOURNAL 1073 post-mortem examination was performed by Dr. H. I. Coombs.The signs were regarded as those of diabetes.The operation area was clean, without sepsis or haematoma and with no evidence of injury to the bladder or urethra.The patient wouild not have died if she had not been operated upon, but there is no reason to believe that the especial character of the operation was the dominant cause of the development of diabetic coma.This fatal case is not included in the series.
Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline.
Authors: R H Adamson, S Takayama, T Sugimura, U P Thorgeirsson
Journal: Environmental Health Perspectives (1994)

The heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated for carcinogenic effects in macaques, primarily cynomolgus monkeys. IQ was administered by gavage five times a week at doses of 10 or 20 mg/kg. IQ induced hepatocellular carcinoma in 55% of the animals at the low dose and in 95% of the animals at 20 mg/kg. The average latent period at the high dose level was 43 months and that at the low dose was 60 months. Generally, the tumor nodules exhibited a well- to moderately well-differentiated hepatocellular carcinoma, and a trabecular pattern was most frequently seen. Pulmonary metastases were also found in several of the monkeys. Thus, IQ is a potent carcinogen in nonhuman primates and is a potential carcinogen for humans.
The Tromso heart study: coffee consumption and serum lipid concentrations in men with hypercholesterolaemia: an randomised intervention study.
Authors: O H Forde, S F Knutsen, E Arnesen, D S Thelle
Journal: BMJ (1985)

again in subjects returning to boiled coffee but remained the same in those returning to filter coffee.Abstention from heavy coffee drinking is an efficient way of reducing serum cholesterol concentrations in men with hypercholesterolaemia.The extent to which the brewing method affects this relation requires further study.
Review of Toxicity of Oxyphenbutazone
Authors: Frank B. Armstrong
Journal: JAMA (1961)

A NEW antirheumatic agent, oxyphenbutazone (p-hydroxyphenylbutazone) synthesized by pfister and Hafliger, 1 has been found to be identical with Metabolite I, discovered by Burns and associates 2 in the urine of patients receiving phenylbutazone. The chemical structure of oxyphenbutazone differs from that of phenylbutazone in the presence of a hydroxyl group on the para position of the benzene ring. Experimental pharmacologic studies in animals have demonstrated that oxyphenbutazone possesses the potency of phenylbutazone as an anti-inflammatory agent, but that it apparently does not have the tendency of the latter to produce serious side effects.  Oxyphenbutazone has had several clinical trials in the treatment of various rheumatic conditions, including rheumatoid arthritis, and no serious side effects have so far been reported. 2-6 Hart and Burley, 3 who used oxyphenbutazone in 117 patients with rheumatic conditions, commented similarly on its low toxicity. Fourteen of their patients were observed for 3 to 12
Evaluation of screening for hypertension in general practice with an automatic machine.
Authors: W P Stephens, R D Tunbridge, D A Moss
Journal: BMJ (1983)

An automatic device for measuring blood pressure was used to screen all patients aged 30 to 65 years registered at a health centre. Of those who were eligible, 55% attended. Patients with previously recognised hypertension were more common among the attenders than among the non-attenders. High readings obtained on the automatic device possibly deterred some patients from reattending for follow up measurements of blood pressure. Although the device is quick and easy to use, the logistic challenge of formal blood pressure screening is considerable. Hypertension was discovered in 52 patients (mean diastolic pressure greater than 100 mm Hg). Retrospective analysis of their medical records showed that a third had had an abnormal blood pressure reading noted during the past 10 years and no further action had been taken, and almost three quarters had attended their practitioner during the previous year without having a blood pressure measurement recorded. One year after the screening procedure two fifths of the newly discovered hypertensive patients had defaulted from follow up and treatment. Automatic devices are not a short cut to the discovery of occult hypertension. Case finding by routine measurement of blood pressure at surgery visits is more efficient.
Counselling for burnout in Norwegian doctors: one year cohort study
Authors: K. E I. Ro, T. Gude, R. Tyssen, O. G Aasland
Journal: BMJ (2008)

To investigate levels and predictors of change in dimensions of burnout after an intervention for stressed doctors.Cohort study followed by self reported assessment at one year.Norwegian resource centre.227 doctors participating in counselling intervention, 2003-5.Counselling (lasting one day (individual) or one week (group based)) aimed at motivating reflection on and acknowledgement of the doctors' situation and personal needs.Levels of burnout (Maslach burnout inventory) and predictors of reduction in emotional exhaustion investigated by linear regression.185 doctors (81%, 88 men, 97 women) completed one year follow-up. The mean level of emotional exhaustion (scale 1-5) was significantly reduced from 3.00 (SD 0.94) to 2.53 (SD 0.76) (t=6.76, P<0.001), similar to the level found in a representative sample of 390 Norwegian doctors. Participants had reduced their working hours by 1.6 hours/week (SD 11.4). There was a considerable reduction in the proportion of doctors on full time sick leave, from 35% (63/182) at baseline to 6% (10/182) at follow-up and a parallel increase in the proportion who had undergone psychotherapy, from 20% (36/182) to 53% (97/182). In the whole cohort, reduction in emotional exhaustion was independently associated with reduced number of work hours/week (beta=0.17, P=0.03), adjusted for sex, age, and personality dimensions. Among men "satisfaction with the intervention" (beta=0.25, P=0.04) independently predicted reduction in emotional exhaustion.A short term counselling intervention could contribute to reduction in emotional exhaustion in doctors. This was associated with reduced working hours for the whole cohort and, in men, was predicted by satisfaction with the intervention.
Early Experiences With Azathioprine in Ulcerative Colitis
Authors: Gerald E. Bowen
Journal: JAMA (1966)

Several informative studies have described the use of immunosuppressive agents in diseases classified as auto-immune in pathogenesis. Dameshek and Schwartz<sup>1,2</sup>have shown that certain antimetabolities are capable of creating a drug-induced immunologic tolerance that theoretically should reduce the activity of diseases produced by altered immune mechanisms. Various immunosuppressive agents have been observed experimentally to reduce or prevent the primary<sup>3,4</sup>and secondary<sup>5</sup>immune response in animals, decrease the level of γ-globulin,<sup>6</sup>inhibit immediate and delayed hypersensitivity,<sup>7</sup>and to induce a prolonged functionalsurvival state in homograft material.<sup>8,9</sup>Furthermore, various clinical trials<sup>10-13</sup>suggest potential beneficial effects of immunosuppressive agents in diseases such as systemic lupus erythematosus, auto-immune hemolytic anemia, hyperglobulinemia purpura, erythema nodosum, and polyarteritis nodosa, identified with immunologic mechanisms. One of these agents, azathioprine (Imuran)<sup>14,15</sup>has shown sufficient promise to justify a clinical trial in ulcerative colitis. Azathioprine is a heterocyclic derivative of 6-mercaptopurine
THE SERUM DIAGNOSIS OF TYPHOID FEVER.
Authors: A. R. GUERARD
Journal: JAMA (1897)

The following is a summary of the methods employed and the results obtained in the use of this test in the Health Department of New York city up to May 1, 1897, including a collective investigation of the results obtained by the principal observers up to the present time, taken from the published reports on the subject.  It is now nearly a year since Widal published his first communication on the serum diagnosis of typhoid fever. Charrin and Roger, Gruber, Pfeiffer and Kolle, and others, had previously observed the phenomena described by Widal, viz.: the immobilization and agglutination of the respective bacilli in the blood serum of animals artificially immunized against infection from the bacillus pyocyanus, the cholera vibrio and Eberth's bacillus, and Pfeiffer had suggested that a differential diagnosis of typhoid fever might be made by means of the serum of animals immunized against typhoid infection. But to Widal
Survey of a Protocol to Increase Appropriate Implementation of Dispatcher-Assisted Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest
Authors: Yoshio Tanaka, Taiki Nishi, Keiko Takase, Yutaka Yoshita, Yukihiro Wato, Junro Taniguchi, Yoshitaka Hamada, Hideo Inaba
Journal: Circulation (2014)

Background— Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) attempts to improve the management of out-of-hospital cardiac arrest by laypersons who are unable to recognize cardiac arrest and are unfamiliar with CPR. Therefore, we investigated the sensitivity and specificity of our new DA-CPR protocol for achieving implementation of bystander CPR in out-of-hospital cardiac arrest victims not already receiving bystander CPR. Methods and Results— Since 2007, we have applied a new DA-CPR protocol that uses supplementary key words. Fire departments prospectively collected baseline data on DA-CPR from January 2009 to December 2011. DA-CPR was attempted in 2747 patients; of these, 417 (15.2%) did not experience cardiac arrest. The sensitivity and specificity of the 2007 protocol versus estimated values of the previous standard protocol were 72.9% versus 50.3% and 99.6% versus 99.8%, respectively. We identified key words that may be useful for detecting out-of-hospital cardiac arrest. Multiple logistic regression analysis revealed that the occurrence of cardiac arrest after an emergency call (odds ratio, 16.85) and placing an emergency call away from the scene of the arrest (odds ratio, 11.04) were potentially associated with failure to provide DA-CPR. Furthermore, at-home cardiac arrest (odds ratio, 1.61) and family members as bystanders (odds ratio, 1.55) were associated with bystander noncompliance with DA-CPR. No complications were reported in the 417 patients who received DA-CPR but did not have cardiac arrest. Conclusions— Our 2007 protocol is safe and highly specific and may be more sensitive than the standard protocol. Understanding the factors associated with failure of bystanders to provide DA-CPR and implementing public education are necessary to increase the benefit of DA-CPR.
Tight junction defects in patients with atopic dermatitis
Authors: Anna De Benedetto, Nicholas M. Rafaels, Laura Y. McGirt, Andrei I. Ivanov, Steve N. Georas, Chris Cheadle, Alan E. Berger, Kunzhong Zhang, Sadasivan Vidyasagar, Takeshi Yoshida, Mark Boguniewicz, Tissa Hata, Lynda C. Schneider, Jon M. Hanifin, Richard L. Gallo, Natalija Novak, Stephan Weidinger, Terri H. Beaty, Donald Y.M. Leung, Kathleen C. Barnes, Lisa A. Beck
Journal: Journal of Allergy and Clinical Immunology (2010)
Enterovirus 71 — Emerging Infections and Emerging Questions
Authors: Raphael Dolin
Journal: New England Journal of Medicine (1999)

Enteroviruses are members of a family of viruses (the picornaviruses) that commonly infect humans throughout the world. They are associated with a broad range of diseases, including various enanthems and exanthems, hemorrhagic conjunctivitis, myocarditis, pericarditis, several central nervous system syndromes (most commonly aseptic meningitis), and undifferentiated febrile illnesses with or without respiratory tract symptoms. Almost all enteroviral infections are probably either asymptomatic or mild and self-limited. Historically, enteroviruses have been divided into the following subgroups largely on the basis of differences in the range of hosts and pathogenicity: the polioviruses, group A coxsackieviruses, group B coxsackieviruses, and echoviruses. Serologically distinct . . .
Hepatic Localization of Tc-99m MAA in Inferior Vena Cava Obstruction
Authors: HENRY W. VEA, MANUEL D. CERQUEIRA
Journal: Clinical Nuclear Medicine (1985)

Two cases of hepatic localization of Tc-99m MAA following injection through the lower extremity venous system are presented. These cases show two different patterns of hepatic uptake, which are related to the likely routes of ilioportal shunting in inferior vena cava obstruction.
Calusterone Treatment Of Breast Cancer
Authors: Ezra M. Greenspan
Journal: JAMA (1972)

To the Editor.—  Two statements in the recently published Therapeutic Grand Rounds on Clusterone in the treatment of advanced breast cancer cast some doubt on the validity of Dr. Gilbert Gordon's enthusiasm for this nontoxic, weak, androgenic steroid. In reply to the question, How effective is the agent for the young patient in her third decade who has already had bilateral oophorectomy? The reply was, It is in this group that the agent has workedextremelywell.... Dr. Gordon also stated that Also, the compound worked equally well in the unfavorable groups of young women in patients with visceral metastases in the lungs and liver. Data are not presented to support these statements. Moreover, it seemed to me that the better calusterone responders used as case illustrations may have been conditioned by previously ineffective estrogen therapy. A 51% response rate as a primary hormonal agent seems unprecedented, especially if indeed
Does It Make Clinical Sense to Equate Terminally III Patients Who Require Life-Sustaining Interventions With Those Who Do Not?
Authors: Ann Alpers
Journal: JAMA (1997)

Two US courts of appeals have ruled that competent, terminally ill patients have a constitutional right to physician-assisted suicide. The cases are now before the US Supreme Court, which is expected to issue a ruling later this year. This article analyzes the keystone of the courts' ruling: their assertion that competent, terminally ill patients who are being kept alive on life support are equivalent to competent, terminally ill patients who do not require such support. Because the former are permitted to end their lives by refusing treatment, the courts found that the latter also have a right to determine the time and manner of their death, through prescriptions for lethal doses of medication. This article analyzes whether the courts' thinking is premised on a clinically plausible view of the care of terminally ill patients. Based on a discussion of common situations involving terminal illness, we argue that the courts' reasoning is deeply flawed. The article also analyzes how the implications of the courts' reasoning might undermine the care of terminally ill patients.
A CALCAREOUS CALCULUS IN THE SUBSTANCE OF THE LIVER.
Authors: WILLIAM A. BYRD
Journal: JAMA (1884)

Read in Section of Surgery and Anatomy, American Medical Association, May, 1884. It will not be necessary for me at this place to write of the genesis of calculi in general, but to call your attention to the fact that although frequently found in the urinary bladder, kidneys, and other portions of the body, that any concretions other than biliary calculi are so seldom found in the liver that any mention of the fact has to be sought for in works upon general pathology, and mention is then made in a vague manner, as the following from a "Manual of General Pathology" by Ernst Wagner, American Edition, p. 319: "Sometimes calcification arises in consequence of metastases. In extensive resorption of earthy salts from the bones (extended caries, numerous carcinomata of the bones, etc.), and the prevented excretion of them through the kidneys, the lime-salts, e. g., are deposited in other