tbuckley/cabot-search huggingface dataset:
Altered density of glomerular binding sites for atrial natriuretic factor in bile duct–ligated rats with ascites
Authors: Alexander L. Gerbes, Margit C. Kollenda, Angelika M. Vollmar, JÜRg Reichen, Nimish Vakil, Robert M. Scarborough
Journal: Hepatology (1991)

The renal response to atrial natriuretic factor is blunted in cirrhosis with ascites. This might be due to alterations of renal receptors for atrial natriuretic factor. Therefore density and affinity of glomerular atrial natriuretic factor binding sites of bile duct-ligated rats with ascites (n = 10) and of sham-operated controls (n = 10) were determined. Glomerular atrial natriuretic factor binding sites were identified to be of the B-("biologically active") and C-("clearance") receptor type. Discrimination and quantitative determination of B and C receptors for atrial natriuretic factor were achieved by displacement experiments with atrial natriuretic factor(99-126) or des(18-22)atrial natriuretic factor(4-23), an analogue binding to C receptors only. Density of total glomerular atrial natriuretic factor binding sites was significantly increased in bile duct-ligated rats (3,518 +/- 864 vs. 1,648 +/- 358 fmol/mg protein; p less than 0.05). This was due to a significant increase of C-receptor density (3,460 +/- 866 vs. 1,486 +/- 363 fmol/mg protein; p less than 0.05), whereas density of B receptors was not significantly different in bile duct-ligated rats (58 +/- 11 vs. 162 +/- 63 fmol/mg protein). Affinity of atrial natriuretic factor to its glomerular binding sites did not differ significantly between both groups. These data suggest that an altered glomerular atrial natriuretic factor receptor density could be involved in the renal resistance to atrial natriuretic factor in cirrhosis with ascites.
On Vivisection and Scientific Surgery
Authors: S. Gamgee
Journal: BMJ (1876)

THE BRITISH MEDICAL 7OURNAL. (JUly 2a, l5k6 pons and the pyramid, down to the lateral column of the spinal cd .Wben this condition has been fully developed, no kind of treatment is of any avail; and it appears, therefore, for this reason alone, that your therapeutical efforts should not be postponed a day longer than you can help it.Ergot, in the form of the liquid extract, for the cure of any miliary aneurisms which may be in the process of formation; phosphoru.s,for improving the nutrition and function of the injured nerve-cclls in the neighbourhoodl of the lesion; galvanisation and fara- disation, for the stimulation of the paralysel parts, are our sheet- anchors in the treatment of this condition ; and, if sagaciously usedl, will do infinitely more goo(l than the merely expectant plan of treat- ment, Which has hitherto been somewhat too much the fashion in these cases.
GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses
Authors: Hao-Sen Chiang, Yun Zhao, Joo-Hye Song, Song Liu, Ninghai Wang, Cox Terhorst, Arlene H Sharpe, Megha Basavappa, Kate L Jeffrey, Hans-Christian Reinecker
Journal: Nature Immunology (2013)
Quality Indicators for Older Adults
Authors: Sei J. Lee, Louise C. Walter
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Use of a Brief Measure of Therapists’ Initial Impressions of Patients to Predict Treatment Response
Authors: Stanley P. Rosenzweig
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 The Use of a Brief Measure of Therapists' Initial Impressions of Patients to Predict Treatment Response Subject Area: Psychiatry and Psychology Stanley P. Rosenzweig Stanley P. Rosenzweig Day Treatment Center, V.A. Outpatient Clinic, Boston, Mass. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 243–245. https://doi.org/10.1159/000286874 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Stanley P. Rosenzweig; The Use of a Brief Measure of Therapists' Initial Impressions of Patients to Predict Treatment Response. Psychother Psychosom 31 December 1975; 25 (1-6): 243–245. https://doi.org/10.1159/000286874 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Surgeon is accused of carrying out unnecessary surgery
Authors: Fabio Turone
Journal: BMJ (2005)

whom they have a complaint.The report recommends that the Department of Health takes the lead in creating a better core standard for handling complaints that are met by all NHS and social care providers.The new system should adopt a culture of openness and leadership by senior managers and of following up complaints to ensure that mistakes do not recur, says the report."The fifth report of the Shipman inquiry gives us an opportunity to reflect on why the NHS complaints system is still failing patients.We must not lose this opportunity to make change happen at last," said Ms Abraham.
A CONSIDERATION OF PRURIGO, PRURITUS, AND SOME COMMON ITCHING DERMATOSES.
Authors: OLIVER S. ORMSBY
Journal: JAMA (1906)

The object of this paper is to consider the points of interest in some of the commoner diseases of the skin, which are accompanied by the sensation of itching, with special reference to their differential diagnosis. Prurigo is a rare disease, and the only reason for including it here is properly to place it and practically eliminate it. A disease productive of itching of varying intensity is one which sooner or later compels its host to seek for relief. Patients may carry for years without complaint cutaneous eruptions of different kinds that are not productive of physical discomfort, especially when these manifestations are hidden beneath the clothing; but when the peace of mind is disturbed by constant or intermittent suffering incident to the subjective symptom, itching, the physician is sought in the hope of relief. <h3>TERMS DEFINED.</h3> The terms prurigo, pruritus and itching have been used so often interchangeably that
Intestinal Suture with the Gelatin Cylinder.
Authors: C. M. Harpster
Journal: JAMA (1904)

Toledo, Ohio, July 27, 1904. <h3>To the Editor:</h3> —The<i>New York Medical Journal</i>, March 12, 1904, speaks of the work of Hepperlen with the gelatin cylinder as a support during the suturing of the cut ends of the bowel. Five years ago, while surgeon for the Edward Ford Plate Glass Co., I did a great deal of experimental work with soluble cylinders for intestinal supports during the suturing. I found the simple gelatin capsule as satisfactory as any. I add my small indorsement to this method as a simple and rapid way of holding the bowel ends, for quick suturing of the same.
Phenoxybenzamine in Benign Prostatic Obstruction-Reply
Authors: Michael J. Barry
Journal: JAMA (1988)

<h3>In Reply.—</h3> Drs Staub and Staub report a case series of patients with symptomatic benign prostatic hyperplasia (BPH) treated in their medical practice with phenoxybenzamine and suggest that this drug may be a valuable adjunct to "watchful waiting" for these patients. They report "prompt and substantial relief of... symptoms and improved bladder emptying," usually with a dosage of 10 mg/d and few side effects. There have been three small (about 20 patients per group), short (two- to five-week) placebo-controlled randomized trials of phenoxybenzamine vs a placebo.<sup>1-3</sup>The study by Caine et al<sup>1</sup>found significant improvements in frequency and flow rates, but not residual volume (bladder emptying), with 20 mg/d over two weeks. Side effects occurred in 11 of 25 patients, but were not severe enough to stop therapy. Abrams et al<sup>2</sup>found increases in flow rate and a drop in residual urine, a better overall symptom rating,
To perform or not to perform liver biopsy: an alternative view
Authors: D Joy
Journal: Gut (2003)

Roger Chapman ( Gut 2002; 51 :9–10) commenting on the recent important study from Nottingham1 concluded that there is a strong case for liver biopsy in most asymptomatic patients with persistently abnormal liver tests, even when diagnostic serology is negative. This conclusion is reasonable, particularly if diagnostic accuracy is paramount. However, accuracy is not the only consideration and other equally valid conclusions can be made from different viewpoints.

Unfortunately, liver biopsy is often painful,2 requires bed rest for at least six hours,3 and is associated with a small but definite mortality.4 We need to appraise our patients of these factors and the likely benefits so that they can make an informed choice. Standard methods of evidence based medicine can greatly assist us in doing this.

As the predominant finding on biopsy is non-alcoholic fatty liver disease (NAFLD), the first question is: can any other test reliably predict fatty liver in this situation? There are three imaging techniques which can detect fatty liver—ultrasound, computerised tomography, and magnetic …
THE DISTRIBUTION OF ACID MUCOPOLYSACCHARIDES IN COHN FRACTIONS OF HUMAN PLASMA PROTEINS1
Authors: Grace P. Kerby
Journal: Journal of Clinical Investigation (1958)

Acid mucopolysaccharides behaving similarly to chondroitin sulfate on paper electrophoresis and paper chromatography have been demonstrated previously in human leukocytes (1, 2).A chon- droitin sulfate-like substance has been recovered also from blood platelets of rats (3).A similar substance has been demonstrated in human urine (4, 5), and this substance has been identified tenta- tively as chondroitin sulfate A or C (6). Delay in recognizing the occurrence of chondroitin sulfate in plasma was occasioned by failure initially to recognize that the acid mucopolysaccharides of plasma appear to be in combination with plasma proteins.Chondroitin sulfate-like substances have been recovered from human plasma now in a number of laboratories, including our own, and reports concerning recoveries and quantitative levels have appeared (7-9).The acid mucopolysaccharides are recoverable from plasma protein precipitated in the euglobulin fraction.The present report deals with a survey of Cohn fractions of plasma proteins for acid mucopolysaccharide content.Chief occurrence of acid mucopolysaccharides was noted in Fractions III and IV-1. METHODSHuman plasma protein Cohn Fractions I, II, III, IV-1, IV-4 and V were generously furnished for the study by E. R. Squibb and Sons through the kind co- operation of Dr. J. N. Ashworth of the American Na- tional Red Cross.Duplicate 100 mg.samples were tested for acid mucopolysaccharide content by a com- bination and modification of the methods of Badin, Schubert, and Vouras (7) and DiFerrante (5).In brief, the method consisted of enzymatic hydrolysis and defatting 2 of the protein fraction, precipitation of acid
Right-Sided Heart Wall Thickening and Delayed Enhancement Caused by Chronic Active Myocarditis Complicated by Sustained Monomorphic Ventricular Tachycardia
Authors: Yoshiyuki Hama, Nobusada Funabashi, Marehiko Ueda, Tomonori Kanaeda, Masae Uehara, Koki Nakamura, Taichi Murayama, Yoko Mikami, Hiroyuki Takaoka, Miyuki Kawakubo, Kwangho Lee, Hiroyuki Takano, Issei Komuro
Journal: Circulation (2009)
NUTRITIONAL REQUIREMENTS AND FACTORS AFFECTING THE PRODUCTION OF TOXIN OF CLOSTRIDIUM SEPTICUM
Authors: Alan W. Bernheimer
Journal: The Journal of Experimental Medicine (1944)

A medium consisting of a complete acid hydrolysate of casein supplemented with cystine, tryptophan, growth accessory factors, glucose, and inorganic salts, has been developed for the cultivation of Clostridium septicum. Toxin equivalent to 400 to 700 L.D(50) per ml. has been obtained regularly in this medium. The principal factors found to affect the yield of toxin are:- (a) Phase of strain employed: Cultures of Cl. septicum may contain a number of variants. Some of these may be characterized by their colonial morphology on blood agar as: (1) rough, non-hemolytic colonies; (2) smooth, non-hemolytic colonies; (3) smooth, hemolytic colonies. Of these three variants, only the last produces toxin. (b) Quantity of growth and length of time cultures were incubated: The toxin and hemolysin content of cultures increases as the bacterial population increases, reaching a maximum value when the number of bacteria is at a maximum, or shortly thereafter. Upon further incubation, the toxin and hemolysin content decreases. (c) Presence of a hemolysin-inactivating factor: A substance, possibly lipid, and present in cooked meat, is capable of inactivating hemolysin produced in casein hydrolysate medium and can account for the absence of hemolysin from cultures grown in cooked-meat broth.
Randomised trial of two-drug and four-drug maintenance chemotherapy in advanced or recurrent Hodgkin's disease. Medical Research Council's working party on lymphomas.
Authors: P G Smith, N Wald
Journal: BMJ (1979)

Between 1970 and 1975, 108 patients who presented with advanced or recurrent Hodgkin's disease and were free of disease after six courses of chemotherapy with mustine, vinblastine, procarbazine, and prednisone (MVPP) were allocated at random to one of two regiments of maintenance treatment: either intermittent treatment with vinblastine and procarbazine or intermittent treatment with MVPP. After a median follow-up period of nearly five years there was no significant difference between the two groups in either the rate of relapse or death rate. Six of the 55 patients given the two-drug regimen died compared with 10 of the 53 given the four-drug regimen. The four-drug required hospital attendance and was less agreeable than the two-drug regimen. The efficacy of maintenance chemotherapy with the two-drug regimen was no less than that with the four-drug regimen, but the two-drug regimen had several practical advantages.
Abstract A63: Melanoma-educated CD14+ monocytes become myeloid-derived suppressor cell-like and are potent inhibitors of autologous T cells through Cox-2 production and STAT-3 signaling.
Authors: Yumeng Mao, Isabel Poschke, Yago Pico de Coaña, Erik Wennerberg, Andreas Lundqvist, Rolf Kiessling
Journal: Cancer Research (2013)

Abstract Tumors can suppress the host immune system through a variety of cellular mechanisms, such as regulatory T cells, tumor-associated macrophages and most recently discovered, myeloid-derived suppressor cells (MDSCs). We have previously demonstrated that CD14+HLA-DRlo/- cells accumulate in the peripheral blood of advanced melanoma patients and can suppress autologous T cells ex vivo in a STAT-3-dependent manner. However, the role of MDSCs in the melanoma tumor microenvironment remains to be elucidated. In the current study, early-passage human melanoma cell lines induce significant phenotypic changes on CD14+ monocytes resembling MDSCs in advanced stage melanoma patients. Moreover, such melanoma-educated monocytes strongly impair both autologous T cell proliferation and interferon-γ production. Of note, the induction of the suppressive functions in healthy donor-derived monocytes appears to require tumor contact and/or close proximity to the tumor cells, and is largely dependent on cyclooxygenase-2 (Cox-2) production and activation of STAT-3 signaling pathway. Intriguingly, we have also demonstrated that these two mechanisms are directly involved in the T cell suppression induced by these MDSC-like cells. Last but not least, CD14+ cells isolated ex vivo from advanced stage melanoma patient PBMCs (n=5) exhibited inhibition of autologous T cell functions in a dose dependent manner. Blockade of STAT-3 signaling (p=0.0358, n=4) and superoxide production (p=0.0195, n=4) significantly alleviated the T cell suppression. In conclusion, our data demonstrated the importance of STAT-3 and Cox-2 activity in inducing CD14+ monocytes to exhibit MDSC-like properties, which contributes to our knowledge of how immune suppression is initiated in the human melanoma tumor microenvironment. Citation Format: Yumeng Mao, Isabel Poschke, Yago Pico de Coaña, Erik Wennerberg, Andreas Lundqvist, Rolf Kiessling. Melanoma-educated CD14+ monocytes become myeloid-derived suppressor cell-like and are potent inhibitors of autologous T cells through Cox-2 production and STAT-3 signaling. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr A63.
The Critical Shortage—Physicians and Supporting Personnel
Authors: E. HARVEY ESTES
Journal: Annals of Internal Medicine (1968)

There is a growing deficit of physician services, primarily related to increased demands and changing patterns of practice rather than to decreased numbers, and there is a serious maldistribution of physician manpower. However, in some areas in which increased numbers of physicians have been produced, maldistribution problems remain unsolved. The overload of primary physicians is also decreasing the entry of new candidates into the field. Creation of new schools is not likely to meet the deficit; expansion of existing schools is less expensive and more rapid but still inadequate. Increased individual physician productivity must be a major part of any solution. The use of assistants is an achievable and practical goal, as evidenced by early experience with the Duke Physician Assistant Program. The success of technical devices such as computers depends on production of skilled assistants capable of operating them. Part of the advantage of group practice and other organization modifications lies in their making possible more efficient use of assistants.
X-Linked Dilated Cardiomyopathy
Authors: Barbara A. Berko, Michael Swift
Journal: New England Journal of Medicine (1987)

To study the inheritance of idiopathic dilated cardiomyopathy, we investigated a large kindred in which 11 young male members had definite or possible evidence of the disorder. The five affected males for whom we had complete clinical data survived for 5 to 12 months after the onset of symptoms, which occurred early in life (ages 15 to 21 years). In six other males, clinical data were incomplete but suggested possible cardiomyopathy. Three mothers of affected males were given a diagnosis of definite, and two of possible, late-onset dilated cardiomyopathy. These women presented in their 40s with atypical chest pain, and progressive congestive heart failure developed gradually over a period of 10 or more years. X-linked inheritance of dilated cardiomyopathy is suggested in this family by the early onset in males, late onset in females, and no evidence of male-to-male transmission. The late onset of the disease in females, in contrast to the early onset in hemizygous males, is compatible with heterozygosity for the mutant allele. Since most cases of genetically lethal X-linked syndromes appear to be sporadic, for every case of "idiopathic" dilated cardiomyopathy in which X-linked inheritance can be confirmed from family information, it is possible that there are several nonfamilial cases due to a mutation at the same locus. (N Engl J Med 1987; 316:1186–91.)
General practice needs investment to provide enhanced services, says BMA
Authors: G. Iacobucci
Journal: BMJ (2014)

The BMA has launched a new campaign to lobby for greater investment in UK general practice and raise awareness of the “unprecedented strain” currently facing the service.

The Your GP Cares campaign1 will highlight to patients how the pressures of escalating demand and a shortage of funding are affecting GP services and public access. It will urge politicians and policy makers to commit new investment to expand the overall number of GPs and practice staff and to improve premises to enable surgeries to provide an enhanced range of services.

Launching the initiative this …