tbuckley/cabot-search huggingface dataset:
Triple-Phase Bone Scan Findings in Aggressive Fibromatosis Before and After Radiation Therapy
Authors: KILLOL J. THAKORE, TERRY M. HUDSON, DAVID K. MONSON, KENNETH A. SCHEIDT
Journal: Clinical Nuclear Medicine (1994)

The authors present comparative triple-phase bone scan findings in three cases of histologically proven aggressive fibromatosis both before (initial evaluation) and after radiation therapy. The purpose of the study was to compare triple-phase bone scan findings in aggressive fibromatosis both before and after radiation therapy and to determine whether any additional physiological information could be obtained. Before radiation therapy, the triple-phase bone scintigraphy demonstrated increased flow and radiotracer pooling in the areas of tumors on dynamic flow and Immediate blood pool images, respectively. However, the delayed static images demonstrated variable radiotracer uptake. When compared to preradiation therapy triple-phase bone scan, decreased vascularity was well demonstrated in all three patients after radiation therapy. In addition, it also provided information regarding the changes in the size and extent of tumor, nonlnvaded underlying bone, and remainder of the skeleton. This additional information can be particularly useful in patients with equivocal or questionable histologic diagnosis especially from small, unrepresentative biopsies.
WHO calls for better access to medical devices in poor nations
Authors: J. Zarocostas
Journal: BMJ (2010)

<h3>Background/aims</h3> Preventing and treating proliferative vitreoretinopathy (PVR) remain a serious challenge for vitreoretinal surgeons. PVR is a devastating complication of retinal detachment that results in recurrent detachment and limits visual recovery. At present, there is no effective treatment for PVR. <h3>Materials and methods</h3> A retrospective review was performed on a cohort of five consecutive eyes with severe PVR and recurrent retinal detachment that were treated with relaxing retinectomy, extended perfluorocarbon liquid tamponade (4–5 weeks) and a series of intravitreal methotrexate (MTX) injections (100–200 µg/0.05 mL for 10 weeks). <h3>Results</h3> All five patients remained reattached (100%) with 11–27 months of follow-up (mean = 17.4). 4 eyes recovered ambulatory vision (&gt;20/200) with normal intraocular pressure and non-fibrotic laser scars along with the relaxing retinectomy. The initial patient remained reattached, but only had hand motions vision. The only adverse effect noted was mild superficial punctate keratopathy in one patient. <h3>Conclusion</h3> This small, retrospective study suggests that a series of MTX injections may be beneficial for treating complex retinal detachment caused by PVR. Further study is indicated.
Biliary Stenting with a Prototype Expandable Teflon Endoprosthesis
Authors: J. Haringsma, K. Huibregtse
Journal: Endoscopy (1998)

Background and Study Aims: A new balloon-expandable Teflon endoprosthesis was developed for endoscopic placement in the biliary tree. After deployment to its maximum diameter the stent is hardened by exposure to UV light. We present our preliminary results with a prototype 18 Fr prosthesis.
β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination
Authors: Rebecca De Smet, Tine Demoor, Stephanie Verschuere, Melissa Dullaers, Gary R. Ostroff, Georges Leclercq, Liesbeth Allais, Charles Pilette, Marijke Dierendonck, Bruno G. De Geest, Claude A. Cuvelier
Journal: Journal of Controlled Release (2013)
Anti- 2GPI-antibody-induced endothelial cell gene expression profiling reveals induction of novel pro-inflammatory genes potentially involved in primary antiphospholipid syndrome
Authors: C Hamid, K Norgate, D P D'Cruz, M A Khamashta, M Arno, J D Pearson, G Frampton, J J Murphy
Journal: Annals of the Rheumatic Diseases (2007)

<b>Objective:</b> To determine the effects of primary antiphospholipid syndrome (PAPS)-derived anti-β<sub>2</sub>GPI antibodies on gene expression in human umbilical vein endothelial cells (HUVEC) by gene profiling using microarrays. <b>Methods:</b> Anti-β<sub>2</sub>GPI antibodies purified from sera of patients with PAPS or control IgG isolated from normal subjects were incubated with HUVEC for 4 h before isolation of RNA and processing for hybridisation to Affymetrix Human Genome U133A-2.0 arrays. Data were analysed using a combination of the MAS 5.0 (Affymetrix) and GeneSpring (Agilent) software programmes. For selected genes microarray data were confirmed by real-time PCR analysis or at the protein level by ELISA. <b>Results:</b> A total of 101 genes were found to be upregulated and 14 genes were downregulated twofold or more in response to anti-β<sub>2</sub>GPI antibodies. A number of novel genes not previously associated with APS were induced, including chemokines CCL20, CXCL3, CX3CL1, CXCL5, CXCL2 and CXCL1, the receptors Tenascin C, OLR1, IL-18 receptor 1, and growth factors CSF2, CSF3 IL-6, IL1β and FGF18. The majority of downregulated genes were transcription factors/signalling molecules including ID2. Quantitative real-time RT-PCR analysis confirmed the microarray results for selected genes (CSF3, CX3CL1, FGF18, ID2, SOD2, Tenascin C). <b>Conclusions:</b> This study reveals a complex gene expression response in HUVEC to anti-β<sub>2</sub>GPI antibodies with multiple chemokines, pro-inflammatory cytokines, pro-thrombotic and pro-adhesive genes regulated by these antibodies in vitro<i>.</i> Some of these newly identified anti-β<sub>2</sub>GPI antibody-regulated genes could contribute to the vasculopathy associated with this disease.
Psychological impact of alopecia
Authors: Martin F Brewster
Journal: BMJ (2005)

Endovascular repair is not worse than open repair of abdominal aortic aneurysmsEditor-The title and interpretation of the EVAR trial results in the POEM are misleading and incorrect. 1Mortality figures were quoted both as aneurysm related and all cause deaths.The 30 day mortality was 1.7% in the EVAR group, which is significantly lower than 4.7% in the open repair group.Surprisingly, the POEM somehow interpreted 30 day mortality to be less than 1% for both groups, which is clearly an error.The confidence intervals (odds ratio 0.35, 95% confidence interval 0.16 to 0.77, P = 0.009) make type I error unlikely.If preintervention deaths are added to the figures 30 day mortality was calculated at 3.5% for endovascular repair and 7.1% for open surgery. 2 The advantage of endovascular repair is sustained at four years, with 4% aneurysm related deaths in the EVAR group compared with 7% in the open repair group.This confers a 3% absolute reduction in aneurysm related mortality.The all cause mortality rate was comparable in both groups at four years.Endovascular repair offers a 30 day lower risk treatment compared with open surgery in patients who are medically fit with an abdominal aortic aneurysm.Compared with open repair, endovascular repair offers no advantage with respect to all cause mortality and health related quality of life; and is more expensive; however, it confers a 3% improved aneurysm related survival which persists at four years.The POEM's message that endovascular repair is worse than open repair is inaccurate and not evidence based.
Nonlinear finite element analysis of three implant–abutment interface designs
Authors: Chun-Bo Tang, Si-Yu Liu, Guo-Xing Zhou, Jin-Hua Yu, Guang-Dong Zhang, Yi-Dong Bao, Qiu-Ju Wang
Journal: International Journal of Oral Science (2012)

The objective of this study was to investigate the mechanical characteristics of implant–abutment interface design in a dental implant system, using nonlinear finite element analysis (FEA) method. This finite element simulation study was applied on three commonly used commercial dental implant systems: model I, the reduced-diameter 3i implant system (West Palm Beach, FL, USA) with a hex and a 12-point double internal hexagonal connection; model II, the Semados implant system (Bego, Bremen, Germany) with combination of a conical (45° taper) and internal hexagonal connection; and model III, the Brånemark implant system (Nobel Biocare, Gothenburg, Sweden) with external hexagonal connection. In simulation, a force of 170 N with 45° oblique to the longitudinal axis of the implant was loaded to the top surface of the abutment. It has been found from the strength and stiffness analysis that the 3i implant system has the lowest maximum von Mises stress, principal stress and displacement while the Brånemark implant system has the highest. It was concluded from our preliminary study using nonlinear FEA that the reduced-diameter 3i implant system with a hex and a 12-point double internal hexagonal connection had a better stress distribution, and produced a smaller displacement than the other two implant systems. Modeling of dental implant systems with nonlinear finite element analysis (FEA) can differentiate their resistance to physical stress. Chun-Bo Tang of Nanjing Medical University, China, along with dental and engineering colleagues in Nanjing, tested the FEA method in a study of three commonly used designs of implant from different countries. In three dimensions, they simulated the stresses of a force of 170 newtons exerted at an angle of 45° onto the top of the attachment point or abutment of each system. From their results, Tang and colleagues concluded that none of the implants was likely to fail under such a force. The way the implants distributed stress, however, suggested that the design from the USA was superior to those from Germany and Sweden, and was likely to be displaced a smaller distance when in use.
Abstract 1332: Pediatric sarcomas are infiltrated with myeloid derived suppressive cells
Authors: Najat Bouchkouj, Haiying Qin, Susana Galli, John Buckley, Joanna L. Meadors, Shannon Larabee, Crystall L. Mackall, Maria G. Tsokos, Terry J. Fry
Journal: Cancer Research (2010)

Abstract Introduction: Pediatric cancers have been reported to be infiltrated with macrophages. Tumor associated macrophages and myeloid derived suppressive cells (MDSCs) are increasingly recognized to play an important role in cancer immune escape, promote tumor progression by suppression of adaptive immunity, and are associated with poor prognosis in adult cancers. Little is known about the presence and the role of these cells in the pathobiology of pediatric cancers. We sought to analyze pediatric sarcomas for the presence of myeloid cells expressing inducible nitric oxide synthase (iNOS), arginase1 (Arg1), and/or indolamine 2,3 deoxygenase (IDO). Concomitantly, we used a murine model of embryonal rhabdomyosarcoma (ERMS) to further explore MDSCs associated with pediatric sarcomas. Methods: We conducted immunohistochemical (IHC) studies on 20 paraffin embedded tumor samples of rhabdomyosarcoma, Ewing's sarcoma, desmoplastic small round cell tumor and malignant peripheral nerve sheath tumor, assessing for CD68, CD163, iNOS, Arg1 and IDO immunoreactivity. In the murine model, 1×106 RMS M3-9-M murine ERMS cells were injected intramuscularly into the gastrocnemius muscle of C57BL/6 mice. Tumors and spleens were excised on days 7, 12, 16 and 19 post injection and tumor and spleen myeloid cell were analyzed for CD11b, CD11c, Gr-1 and IL4R alpha expression and for gene expression of iNOS, Arg1 and IDO using RT-PCR. Results: Pediatric sarcomas demonstrate significant macrophage infiltration with iNOS, Arg1 and IDO present in most of these samples. Murine ERMS also shows substantial numbers of MDSCs both in the tumor and spleen of tumor bearing mice, with increasing numbers as tumor burden increased. Comparisons between different myeloid cells subsets by relative quantitation of gene expression reveal the presence of an expanded population of cells that bear the hallmarks of MDSCs by expressing iNOS and Arg1. Significantly higher IDO expression was seen in MDSCs compared to other myeloid cells as tumors progressed. Conclusion: Macrophages infiltrating pediatric sarcomas expressed markers associated with MDSCs, which have been shown to contribute to immune evasion and augment tumor growth in several other model systems. Similarly, murine ERMS M3-9-M induced accumulation of MDSCs in spleen and tumor microenvironment, with increasing numbers associated with tumor progression, suggesting that they may play an important role in growth of pediatric sarcomas. Immunomodulation of these cells might be a key step in enhancing the effectiveness of immune-based therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1332.
THE MEDICAL EXAMINER SYSTEM
Authors: TIMOTHY LEARY
Journal: JAMA (1927)

This year is the fiftieth anniversary of the establishment by the state of Massachusetts of the medical examiner system to replace the coroner system. During this period the manifest common sense of the plan, and its successful solution of problems dealing with the violent deaths of human beings, have led to the adoption of the system by all but one of the New England states and by the state of New York. Interest in the system has led to inquiries about it from so large a number of the remaining states that a review of the conditions leading to its foundation, and of the practical outcome of its functioning during this half century, is here presented.  THE CORONER SYSTEM   coroner is of purely English derivation, and the system was inherited by us from our Anglo-Saxon forebears. The office of Coroner is of so greatAntiquity, saith the well read
Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TG 26 mice leading to the prevention of colitis
Authors: C Veltkamp
Journal: Gut (2005)

<b>Background and aims:</b> Erroneous thymic selection of developing T lymphocytes may be responsible for the expansion of self reactive T cells or may contribute to the absence of regulatory T cells important in controlling peripheral inflammatory processes. Colitis in bone marrow (BM) transplanted Tgε26 mice is induced by abnormally activated T cells developing in an aberrant thymic microenvironment. We investigated the protective role of regulatory CD4<sup>+</sup>CD25<sup>+</sup> T cells in this model. <b>Methods:</b> BM from (C57BL/6×CBA/J) F1 mice was transplanted into specific pathogen free Tgε26 mice (BM⇒Tgε26). Transplanted mice received no cells (control), sorted CD4<sup>+</sup>CD25<sup>+</sup>, or CD4<sup>+</sup>CD25<sup>−</sup> cells from mesenteric lymph nodes (MLN) of normal mice. MLN cell subsets were analysed using membrane markers. Cytokine secretion of MLN cells was measured using intracellular cytokine staining and cytokine secretion in anti-CD3 stimulated cell cultures. Colitis was measured by histological scores. <b>Results:</b> CD4<sup>+</sup>CD25<sup>+</sup> cells were reduced in the MLNs of BM⇒Tgε26 mice. Transfer of regulatory CD4<sup>+</sup>CD25<sup>+</sup> but not of CD4<sup>+</sup>CD25<sup>−</sup> cells reduced the number of MLN CD4<sup>+</sup> T cells in BM⇒Tgε26 recipients and increased the number of MLN CD8<sup>+</sup> cells, thereby normalising the CD4<sup>+</sup>/CD8<sup>+</sup> ratio. CD4<sup>+</sup>CD25<sup>+</sup> but not CD4<sup>+</sup>CD25<sup>−</sup> cell transfer into BM⇒Tgε26 mice reduced the number of tumour necrosis factor α<sup>+</sup> CD4<sup>+</sup> cells and increased the secretion of transforming growth factor β by MLN cells. Transfer of 3×10<sup>5</sup> CD4<sup>+</sup>CD25<sup>+</sup> cells after BM transplantation into Tgε26 mice prevented colitis whereas CD4<sup>+</sup>CD25<sup>−</sup> cells had no protective effect. <b>Conclusions:</b> These results suggest that defective selection or induction of regulatory T cells in the abnormal thymus is responsible for the development of colitis in BM⇒Tgε26 mice. Transfer of CD4<sup>+</sup>CD25<sup>+</sup> cells can control intestinal inflammation in BM⇒Tgε26 mice by normalising the number and function of the MLN T cell pool.
TCT-872 Results of transfemoral TAVI in Partner-like Patients – A comparison with Real-World Patients
Authors: Fadi Al-Rashid, Alexander Sedaghat, Alexander Ghanem, Thomas Konorza, Daniel Wendt, Matthias Thielmann, Eberhard Grube, Georg Nickenig, Heinz Jakob, Jan Malte Sinning, Philipp Kahlert, Raimund Erbel, Nikos Werner
Journal: Journal of the American College of Cardiology (2012)
Preventing and treating influenza
Authors: K. Stohr
Journal: BMJ (2003)

WHO estimates that seasonal influenza epidemics result in three to five million cases of severe illness and 250 000 to 500 000 deaths each year in the industrialised world alone. Although vaccination remains the most important measure for reducing this sizeable public health burden, the influenza virus neuraminidase inhibitors, zanamivir and oseltamivir, have been welcomed as long awaited additional tools for treatment and prevention. However, in terms of meeting public health objectives, which include clinical effectiveness in high risk groups and preparedness for the next influenza pandemic, they have important limitations.

As documented in the paper by Cooper et al p 1235) in this issue, neuraminidase inhibitors are clinically effective for the treatment of influenza in otherwise healthy adults and children as well as for prevention of the disease.1 When used as a treatment, they can reduce the duration of uncomplicated disease by about one day, and the likelihood of complications requiring antimicrobial treatment. Taken prophylactically they can decrease the likelihood of developing influenza by 70-90% depending on the …
Stroke vs Alzheimer Disease
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IL-25 and Its Receptor (IL-25R) in Allergic Inflammation: Its Role in VEGF-mediated Angiogenesis
Authors: Q. Meng, W. Wang, C. Fang, L.V. Z., Y. Fan, Y. An, Y. Wang, Y. Liu, T.H. Lee, C.J. Corrigan
Journal: Journal of Allergy and Clinical Immunology (2009)
Myogenic Tone in Isolated Perfused Vessels: OCCURRENCE AMONG VASCULAR BEDS AND ALONG VASCULAR TREES
Authors: EIICHI UCHIDA, DAVID F. BOHR
Journal: Circulation Research (1969)

In situ studies yield only indirect evidence as to whether non-neurogenic vascular tone results from an intrinsic myogenic tendency of the smooth muscle cell to contract or is due to stimulation of the muscle by some vasoactive humoral influence of the environment. In the current study, small resistance vessels from different vascular beds, from various levels of the arterial tree, and from several species were isolated and perfused with physiological salt solution. Under these conditions the environment is devoid of any vasoactive, in-situ, humoral influence, and tonic contraction would have to be of myogenic origin. Myogenic tone was consistently present in smooth muscle from some vascular beds, whereas it was absent from other beds. Myogenic tone was more prevalent in smaller vessels (50 to 100µ o.d.) than in larger ones (100 to 400µ o.d.). Significant differences in this property were observed among the species studied. We conclude that, contrary to the properties classically assigned it as a multiunit smooth muscle, most vascular smooth muscle from resistance vessels is intrinsically and spontaneously active.
Cutaneous melanoma in a patient with neurofibromatosis: a case report and review of the literature
Authors: S. DUVE, J. RAKOSKI
Journal: British Journal of Dermatology (2006)

Journal Article Cutaneous melanoma in a patient with neurofibromatosis: a case report and review of the literature Get access S. DUVE, S. DUVE Department of Dermatology, Technical University, Munich, Germany Dr R.S.Duve, Kurfürstenstrasse 21, 80801 München, Germany. Search for other works by this author on: Oxford Academic Google Scholar J. RAKOSKI J. RAKOSKI Department of Dermatology, Technical University, Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 2, 1 August 1994, Pages 290–294, https://doi.org/10.1111/j.1365-2133.1994.tb08508.x Published: 01 August 1994 Article history Accepted: 07 January 1994 Published: 01 August 1994
Comparative effects of APSAC and rt-PA on infarct size and left ventricular function in acute myocardial infarction. A multicenter randomized study.
Authors: J P Bassand, J Cassagnes, J Machecourt, J R Lusson, T Anguenot, J E Wolf, J Maublant, B Bertrand, F Schiele
Journal: Circulation (1991)

BACKGROUND Recombinant tissue-type plasminogen activator (rt-PA or alteplase) and anisoylated plasminogen streptokinase activator complex (APSAC or anistreplase) have been demonstrated to limit infarct size significantly and to preserve left ventricular function when injected soon after acute myocardial infarction. However, as yet, the efficacy and safety of these two thrombolytic agents have not been directly compared in one trial; this was the aim of this study. METHODS AND RESULTS One hundred eighty-three patients suffering from a first acute myocardial infarction were randomly allocated to either APSAC (30 units over 5 minutes) or single-chain rt-PA (100 mg over a 3-hour period) within 4 hours of the onset of symptoms. Global and regional left ventricular function were assessed from contrast angiography an average of 5.3 +/- 2.3 days after initial therapy. Radionuclide angiography and thallium-201 single-photon emission computerized tomography were performed before hospital discharge. Infarct size was assessed by single-photon emission computerized tomography and expressed in percentage of the total myocardial volume. Ninety patients received APSAC and 93 received rt-PA within a mean period of 172 +/- 52 minutes after the onset of symptoms. The two groups were similar in age, location of the acute myocardial infarction, Killip class, and time of randomization. The patency rate of the infarct-related artery was 72% in the APSAC group and 76% in the rt-PA group (NS). Initial and predischarge left ventricular ejection fraction as well as infarct size were similar in both therapeutic groups (0.50 +/- 0.14 versus 0.52 +/- 0.12 for initial and 0.48 +/- 0.10 versus 0.47 +/- 0.10 for predischarge ejection fraction, 11 +/- 7% versus 9 +/- 7% for infarct size, respectively, for APSAC- and rt-PA-treated patients). Bleeding complications requiring blood transfusion occurred in one APSAC patient and in two rt-PA patients. One patient in the rt-PA group died of a massive intracranial hemorrhage. At the end of the 3-week follow-up period, five APSAC patients (5.5%) and seven rt-PA patients (7.5%) had died. CONCLUSIONS The early infusion of APSAC or rt-PA in acute myocardial infarction produced a similar patency rate, limitation of infarct size, and preservation of left ventricular systolic function with an equivalent rate of bleeding complications.