tbuckley/cabot-search huggingface dataset:
Platelet-Aggregating Factor in Thrombotic Thrombocytopenic Purpura
Authors: JAMES N. ATKINS
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 April 1985Platelet-Aggregating Factor in Thrombotic Thrombocytopenic PurpuraJAMES N. ATKINS, M.D.JAMES N. ATKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-560 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: the interesting article by Dr. Kelton and colleagues (1) concerning the detection of platelet-aggregating factor in thrombotic thrombocytopenic purpura raises two questions that I hope they will clarify.First, when they evaluated aggregation, did they control for isoagglutins? Their article indicated that when they pooled platelets they used ABO-compatible donors, but did the aggregation studies use ABO-compatible platelets with ABO-appropriate serum and cryoprecipitate?Second, why did they use an endpoint of visible agglutination rather than using phase microscopy to look for agglutination or using an aggretometer as Dr. Lain and colleagues (2) did in their study? Visible...References1. KELTON J, MORE J, SANTOS A, and SHERIDAN D. Detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. Ann Intern Med. 1984;101:589-93. LinkGoogle Scholar2. LAIN EC, HARKNESS D, BYRNES J, WALLACH H, and NUNEZ R. Presence of a platelet aggregating factor in the plasma of patients with thrombotic thrombocytopenic purpura (TTP) and it's inhibition by normal plasma. Blood. 1979;53:333-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES N. ATKINS, M.D.Affiliations: Goldsboro Medical Specialists Goldsboro, NC 27530 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBlood Diseases and Neurologic Symptoms 1 April 1985Volume 102, Issue 4Page: 560-561KeywordsMicroscopyPlateletsThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 April 1985 PDF downloadLoading ...
Selective engraftment of donor CD4+25high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation
Authors: Markus G. Seidel, Gerhard Fritsch, Thomas Lion, Birgit Jürgens, Andreas Heitger, Rosa Bacchetta, Anita Lawitschka, Christina Peters, Helmut Gadner, Susanne Matthes-Martin
Journal: Blood (2009)
Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis
Authors: Patrick G. Gallagher, Laurie A. Steiner, Robert I. Liem, Ashley N. Owen, Amanda P. Cline, Nancy E. Seidel, Lisa J. Garrett, David M. Bodine
Journal: Journal of Clinical Investigation (2010)

Defects of the ankyrin-1 gene are the most common cause in humans of hereditary spherocytosis, an inherited anemia that affects patients of all ethnic groups. In some kindreds, linked -108/-153 nucleotide substitutions have been found in the upstream region of the ankyrin gene promoter that is active in erythroid cells. In vivo, the ankyrin erythroid promoter and its upstream region direct position-independent, uniform expression, a property of barrier insulators. Using human erythroid cell lines and primary cells and transgenic mice, here we have demonstrated that a region upstream of the erythroid promoter is a barrier insulator in vivo in erythroid cells. The region exhibited both functional and structural characteristics of a barrier, including prevention of gene silencing in an in vivo functional assay, appropriate chromatin configuration, and occupancy by barrier-associated proteins. Fragments with the -108/-153 spherocytosis-associated mutations failed to function as barrier insulators in vivo and demonstrated perturbations in barrier-associated chromatin configuration. In transgenic mice, flanking a mutant -108/-153 ankyrin gene promoter with the well-characterized chicken HS4 barrier insulator restored position-independent, uniform expression at levels comparable to wild-type. These data indicate that an upstream region of the ankyrin-1 erythroid promoter acts as a barrier insulator and identify disruption of the barrier element as a potential pathogenetic mechanism of human disease.
Colonoscopy for Small Adenomas
Authors: James C. Hurowitz
Journal: Annals of Internal Medicine (1999)

Letters20 April 1999Colonoscopy for Small AdenomasJames C. Hurowitz, MDJames C. Hurowitz, MDThe Hurowitz Medical Group; Worcester, MA 01609 (Hurowitz)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-8-199904200-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The 15 August 1998 issue of Annals included recommendations for colonoscopy that are, essentially, diametrically opposed to each other.Wallace and colleagues (1) conclude that colonoscopy is unnecessary in patients found to have single tubular adenomas 5 mm or less in diameter during screening sigmoidoscopy because the prevalence of advanced, more proximal polyps is so low. Dr. Greenberger, on the other hand (2), cites the study by Read and colleagues, which concludes the opposite.As someone trained in epidemiology, I have become increasingly cynical about the value of population studies because it seems that their conclusions can ...References1. Wallace MB, Kemp JA, Trnka YM, Donovan JM, Farraye FA. Is colonoscopy indicated for small adenomas found by screening flexible sigmoidoscopy? Ann Intern Med. 1998;129:273-8. LinkGoogle Scholar2. Greenberger NJ. Update in gastroenterology. Ann Intern Med. 1998;129:309-16. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: James C. Hurowitz, MDAffiliations: The Hurowitz Medical Group; Worcester, MA 01609 (Hurowitz) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIs Colonoscopy Indicated for Small Adenomas Found by Screening Flexible Sigmoidoscopy? Michael B. Wallace , James Alan Kemp , Yvona M. Trnka , Joanne M. Donovan , and Francis A. Farraye Colonoscopy for Small Adenomas Kenneth W. Stubbs Colonoscopy for Small Adenomas Thomas E. Read , Julie D. Read , and Lynn F. Butterly Colonoscopy for Small Adenomas Norton J. Greenberger Colonoscopy for Small Adenomas Michael B. Wallace , Francis A. Farraye , and James Alan Kemp Metrics 20 April 1999Volume 130, Issue 8Page: 700KeywordsAdenomasColonoscopyEpidemiologyPatients ePublished: 15 August 2000 Issue Published: 20 April 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Epidemic ataxia in Western Nigeria.
Authors: T S David-West
Journal: BMJ (1972)

of the specialized tissue.He felt that for inhibition to occur it should be shown that the vagus nerve innervated the entire ventricular specialized network, and that acetyl- choline should be shown to suppress spon- taneous activity of ventricular Purkinje fibres.It would seem that these two conditions also require to be met with regard to vera- pamil and the human heart before the claims of Drs.Livesley and Oram can be justified.-I am, etc.,
Drug-induced photo-onycholysis: three sub-types revealed in a study of 15 cases
Authors: R. Baran, L. Juhlin
Journal: British Journal of Dermatology (1987)

We have studied 15 patients with photo-onycholysis induced by tetracycline derivatives, trioxsalen and fiuoroquinolones.1 Histological examination was performed in five cases. Three distinct clinical sub-types of onycholysis were seen, a classification justified by their different appearence. In Type I (nine cases) several fingers showed the separating part of the nail plate to be half-moon shaped, concave distally with varying pigmentation proximally. Type II (three cases) demonstrated on just one finger a well-defined, circular notch, widest distally and with a brownish hue proximally; the shape was as if the distal nail plate had acted as a convex lens focusing the light on the hyponychium and the distal nail bed. Type III (three cases) showed on several fingers such changes in the central part of the pink nail bed with no connection to the distal or lateral nail margins. This type shows the link between photo-onycholysis and subungual photo-haemorrhage. The latter represents an aspect or a sequel of photo-onycholysis and depends on the timing. UV-irradiation of normal fingernails with various wavelengths (313, 340, 360 and 400 nm) showed that 3–20% of the radiation could penetrate. The different patterns of photo-damage are due to the fact that the nail acts as a lens. Less protection through lack of melanin, and absence of sebum and a stratum granulosum favour penetration of UV-radiation and explain why the skin is not always affected. Discrete subungual hyperkeratosis resulting in keratin dust also explains some changes, such as nail dyschromia, so far attributed to haemorrhages or melanin deposition.
The spectrum of Evans syndrome in adults: new insight into the disease based on the analysis of 68 cases
Authors: Marc Michel, Valérie Chanet, Agnès Dechartres, Anne-Sophie Morin, Jean-Charles Piette, Lorenzo Cirasino, Giovanni Emilia, Francesco Zaja, Marco Ruggeri, Emmanuel Andrès, Philippe Bierling, Bertrand Godeau, Francesco Rodeghiero
Journal: Blood (2009)
Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments
Authors: Mikhail Kosiborod, Gabriel E. Soto, Philip G. Jones, Harlan M. Krumholz, William S. Weintraub, Prakash Deedwania, John A. Spertus
Journal: Circulation (2007)

Background— Identification of heart failure outpatients at increased risk for clinical deterioration remains a critical challenge, with few tools currently available to assist clinicians. We tested whether serial health status assessments with the Kansas City Cardiomyopathy Questionnaire (KCCQ) can identify patients at increased risk for mortality and hospitalization. Methods and Results— We evaluated 1358 patients with heart failure after an acute myocardial infarction in the Eplerenone’s Neurohormonal Efficacy and Survival Study, a multicenter randomized trial that included serial KCCQ assessments. Cox proportional-hazards models were used to examine whether changes in KCCQ scores during successive outpatient visits were independently associated with all-cause mortality and cardiovascular mortality or hospitalization. Change in KCCQ (ΔKCCQ) was linearly associated with all-cause mortality (hazard ratio [HR], for each 5-point decrease in ΔKCCQ, 1.11; 95% CI, 1.04 to 1.19) and the combined outcome of cardiovascular mortality or hospitalization (HR for each 5-point decrease in ΔKCCQ, 1.12; 95% CI 1.07 to 1.18). In Kaplan-Meier survival analysis, all-cause mortality among patients with ΔKCCQ of ≤−10, &gt;−10 to &lt;10, and &gt;10 points was 26%, 16%, and 13%, respectively ( P =0.008). After multivariable adjustment, the linear relationship between ΔKCCQ and both all-cause mortality and combined cardiovascular death and hospitalization persisted (HR, 1.09; 95% CI, 1.00 to 1.18; and HR, 1.11; 95% CI, 1.05 to 1.17 for each 5-point decrease in ΔKCCQ, respectively). Conclusions— In heart failure outpatients, serial health status assessments with the KCCQ can identify high-risk patients and may prove useful in directing the frequency of follow-up and the intensity of treatment.
Responding to out of hours requests for visits: a survey of general practitioner opinion
Authors: B V Court, C P Bradley, K K Cheng, R J Lancashire, R J Lancashire
Journal: BMJ (1996)

The effect of general practitioner fundholding on access to outpatient services is unclear but is of great importance as fundholding expands * Patients of fundholders had no better access than patients of non-fundholders to orthopaedic services before the practices became fundholding * Fundholders controlled their referrals better than non-fundholders and achieved a better balance between referrals and attendances * Fundholders' patients were more likely to be seen quickly, especially if the receiving hospital laid on specific clinics exclusively for fundholders * Information on case mix is needed to identify whether the lower referral rate among fundholders benefits or disadvantages patients
C1q/Tumor Necrosis Factor-Related Protein-3, a Newly Identified Adipokine, Is a Novel Antiapoptotic, Proangiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart
Authors: Wei Yi, Yang Sun, Yuexing Yuan, Wayne Bond Lau, Qijun Zheng, Xiaoliang Wang, Yajing Wang, Xiying Shang, Erhe Gao, Walter J. Koch, Xin-Liang Ma
Journal: Circulation (2012)

Background— Obesity and diabetes mellitus adversely affect postischemic heart remodeling via incompletely understood mechanisms. C1q/tumor necrosis factor–related protein-3 (CTRP3) is a newly identified adipokine exerting beneficial metabolic regulation, similar to adiponectin. The aim of the present study was to determine whether CTRP3 may regulate postischemic cardiac remodeling and cardiac dysfunction, and, if so, to elucidate the underlying mechanisms. Methods and Results— Male adult mice were subjected to myocardial infarction (MI) via left anterior descending coronary artery occlusion. Both the effect of MI on endogenous CTRP3 expression/production and the effect of exogenous CTRP3 (adenovirus or recombinant CTRP3) replenishment on MI injury were investigated. MI significantly inhibited adipocyte CTRP3 expression and reduced the plasma CTRP3 level, reaching a nadir 3 days after MI. CTRP3 replenishment improved survival rate ( P &lt;0.05), restored cardiac function, attenuated cardiomyocyte apoptosis, increased revascularization, and dramatically reduced interstitial fibrosis (all P &lt;0.01). CTRP3 replenishment had no significant effect on cardiac AMP-activated protein kinase phosphorylation but significantly increased Akt phosphorylation and expression of hypoxia inducing factor-1α and vascular endothelial growth factor. Surprisingly, treatment of human umbilical vascular endothelial cells with CTRP3 did not directly affect nitric oxide production or tube formation. However, preconditioned medium from CTRP3-treated cardiomyocytes significantly enhanced human umbilical vascular endothelial cell tube formation, an effect blocked by either pretreatment of cardiomyocytes with a PI3K inhibitor or pretreatment of human umbilical vascular endothelial cells with a vascular endothelial growth factor inhibitor. Finally, the protective effect of adipocyte-conditioned medium against hypoxia-induced cardiomyocyte injury is significantly blunted when CTRP3 is knocked down. Conclusion— CTRP3 is a novel antiapoptotic, proangiogenic, and cardioprotective adipokine, the expression of which is significantly inhibited after MI.
The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
Authors: Mateusz Legut, David K Cole, Andrew K Sewell
Journal: Cellular and Molecular Immunology (2015)

Abstract γδ T cells form an important part of adaptive immune responses against infections and malignant transformation. The molecular targets of human γδ T cell receptors (TCRs) remain largely unknown, but recent studies have confirmed the recognition of phosphorylated prenyl metabolites, lipids in complex with CD1 molecules and markers of cellular stress. All of these molecules are upregulated on various cancer types, highlighting the potential importance of the γδ T cell compartment in cancer immunosurveillance and paving the way for the use of γδ TCRs in cancer therapy. Ligand recognition by the γδ TCR often requires accessory/co-stimulatory stress molecules on both T cells and target cells; this cellular stress context therefore provides a failsafe against harmful self-reactivity. Unlike αβ T cells, γδ T cells recognise their targets irrespective of HLA haplotype and therefore offer exciting possibilities for off-the-shelf, pan-population cancer immunotherapies. Here, we present a review of known ligands of human γδ T cells and discuss the promise of harnessing these cells for cancer treatment.
Systemic haemodynamic changes due to pulmonary embolization in rabbits as influenced by trimethaphancamsylate
Authors: J. KASALICKY
Journal: Cardiovascular Research (1972)

The effect of trimethaphancamsylate (Arfonad, Roche) on the transformation of systemic circulation occurring as a result of pulmonary embolization was examined in a group of rabbits with pulmonary embolization caused by x-ray contrast blood clots. This group was compared with a control group and with a group of rabbits with pulmonary embolization after the application of Arfonad. Pulmonary embolization results in systemic arterial hypotension, decrease of total systemic resistance, and decrease of perfusion in kidneys, splanchnic organs, and in lungs and skin, whereas the perfusion of myocardium and skeletal muscle is retained. Arfonad abolished this vasoconstriction; nevertheless it also decreased cardiac output, probably due to the reduced venous return, and aggravated the systemic hypotension. This effect of Arfonad indicated that the transformation of circulation in pulmonary embolization was of reflex origin.
Genetic Regulation of the Response to Her-2 DNA Vaccination in Human Her-2 Transgenic Mice
Authors: Olga Radkevich-Brown, Jennifer Jacob, Michael Kershaw, Wei-Zen Wei
Journal: Cancer Research (2008)

Genetic regulation of immune reactivity to Her-2 vaccination and the consequent antitumor effect was tested in human Her-2 transgenic (Tg) mice of C57BL/6 (B6), BALB/c (BALB), and (B6x BALB) F1 (F1) background. Mice were electrovaccinated with Her-2 DNA with or without pretreatment with CD25 monoclonal antibody to remove CD25(hi) regulatory T cells. When CD25(+) T cells were intact, BALB Her-2 Tg mice were more responsive than the other two strains in both humoral and cellular immunities, and their tumor growth was significantly delayed. B6 Her-2 Tg mice responded poorly and F1 mice showed modest immune reactivity, but tumor growth did not change in either strain. Depletion of CD25(hi) T cells before vaccination significantly improved protection from tumor challenge in F1 Her-2 Tg mice. This was associated with elevated levels of Her-2 IgG1, IgG2a, and IgG2c antibodies, and some mice also showed IFN-gamma producing T-cell response. The same treatment induced modest improvement in B6 Her-2 Tg mice. In BALB Her-2 Tg mice, however, depletion of CD25(hi) T cells did not further improve antitumor efficacy. Although their Her-2-specific IgG1 and interleukin-5-secreting T cells increased, the levels of IgG2a and IFN-gamma-secreting T cells did not change. These results are the first to show genetic regulation of the response to a cancer vaccine and an unequal effect of removing CD25(hi) T cells on antitumor immunity. These results warrant individualized treatment plans for patients with heterogeneous genetic backgrounds and possibly differential intrinsic immune reactivity to tumor antigens.
ACUTE CHOREA, RECOVERY.
Authors: CHARLES S. WALKER
Journal: JAMA (1902)

ABSTRACT F. O. B., male, aged 31, single, with no particular occupation, but having worked in a wood planing-mill in Massachusetts, entered the New Hampshire State Hospital, Concord, N. H., Oct. 9, 1901. He had not been well for four weeks. In the history of the case it was intimated that he had been a little odd since childhood—not quite as adept a scholar as some of his chums. His family medical attendant said the only severe illness that the patient had ever had was enteric fever, 15 years ago, from which he made a perfect recovery.Physical examination showed height, 5 ft. 6% in.; weight 122 pounds; poorly nourished; pulse 68; tongue slightly coated; complexion pale; pupils somewhat dilated, but equally, reflexes normal. There was a peculiar dragging to left leg on walking, which was said to be congenital. It is said that his mother, while pregnant, was frightened by
Prescribing antibiotics in general practice
Authors: W Howe
Journal: BMJ (1994)

as Jenkdns and Wingate commented on.Twelve of the children were concerned by change in the affected parent's mental sate or personality; nine expressed uncertainties and fears about the future and fears of getting the disease themselves; eight complained of a limited social life and limited communication in the family; six complained of constant nagging and trivial talk; six said that they could not turn to their affected parent for advice or decisions; and four complained that the affected parent had no idea of their feelings.Our results highlight how even minor or subtle disabilities in a parent can cause children considerable anxiety.While the impact of disability on partners or adult carers is well recognised, the impact on different generations is neglected3 and worthy of further discussion.The complexities of meeting the varied needs of those suffering from multiple sclerosis is being increasingly recognised,4 although the needs of children and young people still fail to be addressed.Meeting the practical needs is straightforward through care attendant schemes.5We still have great difficulties in meeting emotional needs.We wish to emphasise the emotional impact of a disabled parent on his or her children.This is particularly important with regard to cognitive impairments or if the parent is deteriorating (however subtly) from emotional, intellectual, or physical impairments.
Active Myocarditis in the Spectrum of Acute Dilated Cardiomyopathies
Authors: G. William Dec, Igor F. Palacios, John T. Fallon, H. Thomas Aretz, John Mills, Daniel C-S. Lee, Robert Arnold Johnson
Journal: New England Journal of Medicine (1985)

We studied the clinical features and course (average follow-up time, 18 months) of 27 patients with acute dilated cardiomyopathy (symptoms for less than 6 months) who were referred for endomyocardial biopsy. Almost 40 per cent of the patients subsequently had a rise in left ventricular ejection fraction (on average, from 0.21 to 0.41) and substantial improvement in heart failure; the remainder died or had chronic dilated cardiomyopathy. Biopsy revealed myocarditis in 18 patients, and this finding was especially common (89 per cent) in patients who had been ill for less than four weeks. But the biopsy specimen was negative in four patients whose clinical features and later course were diagnostic of myocarditis. Nine patients received immunosuppressive drugs, and four improved--a rate that did not differ from the rate of spontaneous improvement. Neither the histologic features of the biopsy specimen nor the clinical features at presentation were clearly correlated with subsequent improvement, whether or not immunosuppressive drugs were given. We conclude that many cases of unexplained dilated cardiomyopathy result from myocarditis. Definitive histologic confirmation depends on the duration of illness. The efficacy of immunosuppressive treatment must still be established.