tbuckley/cabot-search huggingface dataset:
Color Doppler Ultrasound and Deep Venous Thrombosis
Authors: Richard H. White
Journal: Annals of Internal Medicine (1993)

Letters1 June 1993Color Doppler Ultrasound and Deep Venous ThrombosisRichard H. White, MDRichard H. White, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-11-199306010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Davidson and colleagues [1] report that color Doppler ultrasound has poor diagnostic accuracy for proximal thrombi in high-risk asymptomatic patients receiving medical prophylaxis. The results of this study could affect clinical practice in several different situations. Although clinicians rarely order an ultrasound screening test in patients receiving heparin prophylaxis, they do screen patients at high risk for thrombosis who cannot be given prophylaxis [2] and patients with suspected pulmonary embolism who have an indeterminate lung scan. The low accuracy of ultrasound suggests that venography should be ordered in these situations. However, some reservations about the study methods ...References1. Davidson BL, Elliot CG, Lensing AW, for the RD Heparin Arthroplasty Group. Low accuracy of color flow Doppler ultrasound in the detection of proximal vein thrombosis in asymptomatic high-risk patients. Ann Intern Med. 1992; 117:735-8. Google Scholar2. White RH, Goulet JA, Bray TJ, Daschbach MM, McGahan JP, Hartling RP. Deep-vein thrombosis after fracture of the pelvis: assessment using serial duplex-ultrasound screening. J Bone Joint Surg. 1990; 72-A:495-500. Google Scholar3. McLachlan MS, Thomson JG, Kelly ME, Sackett DL. Observer variation in the interpretation of lower limb venograms. AJR. 1979; 132: 227-9. Google Scholar4. Ginsberg JS, Caco CC, Brill-Edwards PA, Panju AA, Bona R, Demers CM, et al. Venous thrombosis in patients who have undergone major hip or knee surgery: detection with compression ultrasound and impedance plethysmography. Radiology. 1991; 181:735-8. Google Scholar5. Mattos KJ, Londrey GL, Leutz DW, Hodgson KJ, Ramsey DE, Barkmeier LD, et al. Color flow duplex scanning for the surveillance and diagnosis of acute deep venous thrombosis. J Vasc Surg. 1992; 15: 366-76. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDuplex scanning in the postoperative surveillance of patients undergoing total hip arthroplasty 1 June 1993Volume 118, Issue 11Page: 906-907KeywordsLungsOrthopedicsProphylaxisPulmonary embolismRadiologistsSurgeryTechniciansThrombosisUltrasound imagingVeins Issue Published: 1 June 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
GASTRO-HYSTEROPEXY AS A SAFE AND RELIABLE MEANS OF CORRECTING PROLAPSUS AND RETRO-DISPLACEMENTS OF THE UTERUS.
Authors: YOUNG H. BOND
Journal: JAMA (1894)

By far the most frequent displacements to which the uterus is liable are the downward and backward, namely, the various degrees of prolapsus, retroversion and retroflexion. But few if any troubles in the entire field of gynecology impose more of suffering and misery than is entailed by the inflammatory consequences of these affections. The reflex disturbances and the general ill-health that usually follow often lead to melancholia, hysteria, and even more pronounced insanity. In many instances the physical health is wrecked, and the functions of the various systems of the body are so perverted as to lead to a condition of general impairment of nutrition, which predisposes to the activity of any inherited tendency to disease. I should like to emphasize the significance of the phrase, "inflammatory consequences," in this connection; for it is to these that symptoms are chiefly due; for example, pelvic peritonitis, with adhesions binding the uterus,
Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor–resistant acute myeloid leukemia cells
Authors: Warren Fiskus, Rekha Rao, Pravina Fernandez, Bryan Herger, Yonghua Yang, Jianguang Chen, Ravindra Kolhe, Aditya Mandawat, Yongchao Wang, Rajeshree Joshi, Kelly Eaton, Pearl Lee, Peter Atadja, Stephen Peiper, Kapil Bhalla
Journal: Blood (2008)
145 THERAPEUTIC TARGETS IN LIVER TRANSPLANTATION: ANGIOTENSIN II IN NON-STEATOTIC GRAFTS AND ANGIOTENSIN-(1–7) IN STEATOTIC GRAFTS
Authors: I. Alfany-Fernandez, A. Casillas-Ramirez, M. Bintanel-Morcillo, K.B. Brosnihan, C.M. Ferrario, A. Rimola, V. Arroyo, J. Rodés, J. Roselló-Catafau, C. Peralta
Journal: Journal of Hepatology (2009)
A Dozen Eggs
Authors: Gulshan Sharma
Journal: Annals of Internal Medicine (2011)

On Being a Doctor3 May 2011A Dozen EggsGulshan Sharma, MD, MPHGulshan Sharma, MD, MPHFrom The University of Texas Medical Branch at Galveston, Galveston, TX 77555-0561.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-9-201105030-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Not every physician gets patted down daily in his own hospital. The security guard ran his fingers over my picture ID to ensure authenticity.“Sir, you are clear to enter.”As I walked the long tunnel connecting the outside world to the prison hospital, I couldn't prevent mixed feelings, but there was no time to explore them. At the end of the tunnel, I was buzzed in through a second hefty barred door. It opened into a circular enclosure housing the “command center,” manned by a uniformed guard. Seven doors defined the perimeter, with each door definitively shut. I stood ... Author, Article, and Disclosure InformationAffiliations: From The University of Texas Medical Branch at Galveston, Galveston, TX 77555-0561.Corresponding Author: Gulshan Sharma, MD, MPH, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The University of Texas Medical Branch at Galveston, 301 University Boulevard, JSA-5.112, UTMB, Galveston, TX 77555-0561. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 May 2011Volume 154, Issue 9Page: 640-641KeywordsChemotherapyEmotionsHispanic peopleIntensive care unitsNursesNutrientsOutpatient clinicsOxygenRespiratory rateWalking ePublished: 3 May 2011 Issue Published: 3 May 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Induction of myocardial hypertrophy after coronary ligation in rats decreases ventricular dilatation and improves systolic function.
Authors: S E Litwin, T E Raya, P G Anderson, C M Litwin, R Bressler, S Goldman
Journal: Circulation (1991)

BACKGROUND Previous studies have shown that hypertrophy of surviving myocytes after myocardial infarction (MI) is limited. Progressive ventricular dilatation after MI may occur when compensatory hypertrophy cannot restore left ventricular (LV) wall stress to normal. METHODS AND RESULTS To test whether induction of additional myocyte hypertrophy might prevent pathological LV remodeling after large MI, we administered 2-tetradecylglycidic acid (TDGA) 20 mg/kg/day to sham-operated (n = 12) and MI (n = 10) rats for 10 days, beginning the third day after infarction. We have previously shown that chronic inhibition of long-chain fatty acid oxidation with TDGA in rats results in myocardial hypertrophy without any apparent impairment of LV systolic function. When compared with untreated MI rats (n = 9), we found that TDGA-treated MI rats had increases in LV weight/body wt, myocyte cross-sectional area, and peak developed LV pressure during abrupt aortic occlusion. MI rats treated with TDGA had lower LV end-diastolic pressures and smaller end-diastolic volumes, whereas stroke volume was maintained. The ex vivo passive LV pressure-volume relation was shifted toward the pressure axis compared with untreated infarct rats. In sham-operated rats, TDGA caused increases in LV weight/body wt, myocyte size, peak developed LV pressure, cardiac index, and stroke volume index, and a shift of the passive LV pressure-volume relation toward the pressure axis. CONCLUSIONS Induction of myocardial hypertrophy with an inhibitor of long-chain fatty acid oxidation retarded the process of LV dilatation and produced beneficial effects on systolic function after large myocardial infarction. These data support the hypothesis that inadequate hypertrophy of residual myocardium after infarction may contribute to LV dilatation and the development of congestive heart failure.
Incidence of Prostate Cancer Diagnosis in the Eras Before and After Serum Prostate-Specific Antigen Testing
Authors: Steven J. Jacobsen
Journal: JAMA (1995)

<h3>Objective.</h3> —To estimate the incidence of prostate cancer in Olmsted County, Minnesota, from 1983 through 1992 to describe the secular changes that have occurred since the introduction of serum prostate-specific antigen (PSA) testing to the community medical practice in 1987. <h3>Design.</h3> —Population-based, descriptive epidemiological study with ecologic and individual level comparisons over time. <h3>Study Setting.</h3> —Olmsted County, Minnesota, where the Rochester Epidemiology Project provides passive surveillance of the population for health outcomes. <h3>Subjects.</h3> —All 511 biopsy-proven incident cases of adenocarcinoma of the prostate diagnosed from 1983 through 1992. The community inpatient and outpatient medical records of all incident cases were reviewed to evaluate the presenting characteristics of men at the time of diagnosis. <h3>Results.</h3> —The age-adjusted incidence of biopsy-proven prostate cancer increased from 64 per 100 000 person-years in 1983 to 215 per 100 000 person-years in 1992. The increase occurred primarily between 1987 and 1988 and was predominately for organ-confined tumors. The age-specific incidence increased dramatically in this same period among men aged 50 years and older. Among men aged 70 years and older, however, prostate carcinoma incidence rates declined after 1990 following the initial increase. This decline among older men contrasted with community-based estimates of PSA utilization rates, which demonstrated consistent increases since 1987 to nearly 50% of the older population in 1992. <h3>Conclusion.</h3> —These results support the premise that the recent increase in prostate cancer is due in part to the increased utilization of serum PSA testing. Further, the increased incidence appears to be a transient phenomenon due to the depletion of previously undiagnosed cases from the prevalence pool. Finally, these data suggest that, in terms of stage at diagnosis, early detection efforts may be effective in identifying more early stage (smaller) cancers. (<i>JAMA</i>. 1995;274:1445-1449)
Factor V Leiden and third-generation oral contraceptives
Authors: Carolyn Westhoff, KittyW.M. Bloemenkamp, FritsR. Rosendaal, FransM. Helmerhorst, HarryR. Büller, JanP. Vandenbroucke
Journal: The Lancet (1996)

The authors respond to Carolyn Westhoffs critique of their study on the association between exposure to oral contraceptives and deep vein thrombosis (DVT).  They found an apparent multiplication of risks which was more clearly present for oral contraceptives containing a third-generation progestogen than for those containing a second-generation progestogen.  The risks seem to multiply but there is no reason why they should.  The authors explain that the appearance of independence of such risks is merely the result of the use of multiplicative models that is relative risks or logistic models.  These models are a simple result of a mathematical convenience and have no intrinsic biological meaning which becomes clearer when looking at the same data on an additive scale.  The authors agree with Westhoff that the biological interpretation of interaction is considerably more difficult.  They do not however believe that they overstated misinterpreted or misled by suggesting that the observed difference in risk among factor V Leiden positive individuals may offer a clue to the biological mechanism underlying the increased risk of venous thrombosis of third-generation oral contraceptives.
Control of Viscerocutaneous Fistulas by a New Suction Device
Authors: Harry S. Goldsmith
Journal: New England Journal of Medicine (1961)

A SITUATION that can be devastating to a patient as well as tax to the utmost the skill of a surgeon is that of a viscerocutaneous fistula. These fistulas can be of relatively short duration and present little or no problems, an example being the removal of a T tube after common-duct exploration. As opposed to this situation is a lateral duodenal fistula, which can present innumerable problems. This latter type is treated mainly by the protection of the skin surrounding the fistulous orifice and the replacement of fluids and electrolytes.An apparatus† developed for such a problem by removing . . .
Response to Letter Regarding Article, “Right Ventricular Mechanics and QRS Duration in Patients With Repaired Tetralogy of Fallot: Implications of Infundibular Disease”
Authors: Anselm Uebing, Sonya V. Babu-Narayan, Gerhard P. Diller, Konstantinos Dimopoulos, Omer Goktekin, Mark S. Spence, Kai Andersen, Michael A. Gatzoulis, Wei Li, Derek G. Gibson, Michael Y. Henein
Journal: Circulation (2008)

Implications of Infundibular Disease"We thank Dr Abdul-Khaliq and his colleagues for their interest in our study 1 and for their comments to Circulation.We submit that apparent differences between our 2 studies 1,2 are largely methodological in origin.In order to isolate the potential effects of activation, we measured the time interval from Q to onset of motion using M-mode with its high repetition rate.Abdul-Khaliq et al used strain imaging to measure the time interval to maximum strain, which they took to coincide with aortic valve closure (A2). 2 This latter interval also includes ventricular ejection and is thus potentially influenced by loading conditions.As we pointed out in our article, we had very similar results when we took the time interval to peak shortening velocity, which is inscribed at mid ejection and thus subjected to similar influences. 1 We take issue with Abdul-Khaliq et al, however, on the subject of rate dependence.We note that heart rate was not found to be a significant determinant in the particular circumstances of their study.However, the time from Q to A2 has been extensively investigated in the setting of the systolic time intervals, and its rate dependence has been clearly documented. 3Such dependence must always be recognized among other potential confounding factors when any time interval that includes ventricular ejection is studied.A wide scatter was present in the severity of pulmonary regurgitation in our group of patients with repaired tetralogy.The extent of outflow tract asynchrony, however, did not correlate with pulmonary regurgitation but rather with markers of right ventricular outflow tract disease such as akinetic area size or with whether an outflow tract patch was used at the time of repair.It is thus apparent that the degree of pulmonary regurgitation does not necessarily reflect the extent of right ventricular outflow tract damage at the time of tetralogy repair. 4e fully agree with Abdul-Khaliq et al as to the limitations of tissue Doppler in assessing the timing of ventricular motion, limitations that we referred to in our report and which were also underscored by the recent Predictors of Response to Cardiac Resynchronization Therapy (PROSPECT) study.
The New Danger of Thirdhand Smoke: Why Passive Smoking Does Not Stop at Secondhand Smoke
Authors: Carmela Protano, Matteo Vitali
Journal: Environmental Health Perspectives (2011)

ÖZETSigara ya da diğer tütün ürünlerinin yanması sonucu ortaya çıkan duman ile sigara içen kişinin soluğuyla yayılan dumanın bileşimi
A FATAL CASE OF MULTIPLE SUBCUTANEOUS GUMMATA.
Authors: WILLIAM S. GOTTHEIL
Journal: JAMA (1896)

The so-called tertiary lesions are not a necessary consequence of the syphilitic infection. They occur according to Finger's statistics, only in 5 to 40 per cent. of the cases; and Haslund, Mauriac and Neumann give the still lower figures of 5 to 15 per cent. No case of syphilitic infection is, however, safe from the possibility of their occurrence; and the length of time that has elapsed since the commencement of the disease is no guarantee against their appearance. Fournier reports a well authenticated case occurring fifty years after the initial lesion; and tertiarism appearing ten or fifteen years after the sclerosis is not uncommon. The average and most common time, however, is five years. On the other hand, they may appear quite early in malignant syphilis; Mauriac reported a case in which gummata occurred a few months after the infecting chancre, forming what the French call<i>syphilis maligne précoce</i>
Molecular Evidence of Lentiviral Vector-Mediated Gene Transfer into Human Self-Renewing, Multi-potent, Long-Term NOD/SCID Repopulating Hematopoietic Cells
Authors: Laurie Ailles, Manfred Schmidt, Francesca Romana Santoni de Sio, Hanno Glimm, Simona Cavalieri, Stefania Bruno, Wanda Piacibello, Christof Von Kalle, Luigi Naldini
Journal: Molecular Therapy (2002)

A major challenge in gene therapy is to achieve efficient transduction of hematopoietic stem cells (HSC). It has previously been shown that lentiviral vectors (LV) transduce efficiently human cord blood-derived NOD/SCID mouse repopulating cells (SRC). Here we studied the effect of cytokines during the short ex vivo incubation with vector. Although SRC transduction was efficient without stimulation, the presence of cytokines significantly improved it. The treatment did not affect the engraftment level or the SRC frequency, but seemed to enhance SRC susceptibility to LV. SRC transduced in both conditions repopulated primary and secondary recipients, maintaining stable multi-lineage transgene expression. Using linear amplification-mediated PCR, we then analyzed vector integration in the bone marrow and CFC of the engrafted mice to monitor the clonal activity of the transduced SRC in vivo. We showed polyclonal engraftment, multi-lineage differentiation, and propagation to secondary recipients of individual SRC. We observed multiple integrations in most clones. These results provide the first formal demonstration that primitive human HSC with self-renewal and multi-lineage repopulation capacities were transduced by LV. Our findings are relevant for the design of clinical protocols that exploit this system to reach significant engraftment by genetically modified HSC in the absence of in vivo selection or strong conditioning regimens.
Hurrah for Empirical Bioethics (Where Hermeneutically Clarified) or How Perception of Facts ‘Depends’ on Values
Authors: Dawson S. Schultz
Journal: The American Journal of Bioethics (2009)

Hurrah for the benefits, yet beware of the burdens, of Alexander Kon's (2009) approach to empirical bioethics and of evidence-based ethics generally. (For present purposes, I shall refer to these a...
A 24/7 service needs many more doctors
Authors: D. E. Newton
Journal: BMJ (2013)

Written in the vacuum of the ethics dimension, this paper reminds me of the phrase, “it’s the economy stupid.”1 We used these arguments in the BMA negotiating committee, with Barbara Castle and David Owen.

In the 1970s I worked a one in two rota, all night on call. Droves of juniors were resident, however, as were experienced senior registrars. …
Long Term Persistence of IgE Anti-Influenza A HIN1 Virus Antibodies in Serum of Pediatric and Adult Humans Post Influenza A H1N1 Infection
Authors: M. Kusonruksa, D. Wong, K.B. Norowitz, R. Joks, H.G. Durkin, M.H. Bluth, T.A. Smith-Norowitz
Journal: Journal of Allergy and Clinical Immunology (2011)
Chronic hemodynamic overload of the atria is an important factor for gap junction remodeling in human and rat hearts
Authors: C RUCKERMARTIN, P MILLIEZ, S TAN, X DECROUY, M RECOUVREUR, R VRANCKX, C DELCAYRE, J RENAUD, I DUNIA, D SEGRETAIN
Journal: Cardiovascular Research (2006)

Objectives: The expression and distribution of connexins is abnormal in a number of cardiac diseases, including atrial fibrillation, and is believed to favor conduction slowing and arrhythmia. Here, we studied the role of atrial structural remodeling in the disorganization of gap junctions and whether redistributed connexins can form new functional junction channels.
THREE CASES OF PARALYSIS OF THE SERRATUS MAGNUS AND THE TRAPEZIUS— ALAR SCAPULA.
Authors: AUGUSTUS A. ESHNER
Journal: JAMA (1902)

The scapula affords attachment for many large and powerful muscles that play an important part in the varied movements, not alone of the shoulder but also of the entire upper extremity. Thus, the trapezius aids in elevating the scapula and approximating it to the spine; also in rotating the scapula, causing the acromion to ascend and the lower angle to move outward. The action of the trapezius is supplemented by that of the elevator muscle of the angle of the scapula and of the rhomboids, the latter of which rotate the scapula on its outer angle and cause the lower angle to move inward. The serratus magnus moves the scapula outward, forward and slightly upward. It tends to rotate the scapula on its inner angle and thus to elevate the acromion, but in this it is opposed by the elevator muscle of the angle of the scapula and the rhomboids.
Pilot study of recombinant human interleukin 2 for chronic type B hepatitis
Authors: Shinichi Kakumu, Akihiko Fuji, Kentaro Yoshioka, Hirofumi Tahara, Yoshiyuki Ohtani, Hideo Hirofuji, Kenichi Murase, Tsuneto Aoi
Journal: Hepatology (1988)

Recombinant human interleukin 2 was administered to 10 patients with chronic type B hepatitis as a part of a pilot study to evaluate its antiviral activity. Patients received 1 to 3 x 10(5) units per day of interleukin 2 for 21 to 28 days, and all completed the treatment schedule. During therapy, serum values of DNA polymerase decreased in 6 and became negative in four patients. However, when therapy was discontinued, DNA polymerase levels increased to pretreatment levels in most cases. Serum HBeAg levels did not change during treatment. Serum aminotransferase levels transiently increased in 6 of the 10 patients during therapy; but once therapy was stopped, levels fell markedly. Side effects of interleukin 2 therapy included fever, chills, anorexia and fatigue. After 1 year of follow-up, three treated patients had lost HBeAg and had marked improvement in aminotransferase levels. These serologic and biochemical improvements occurred 1.5 to 11 months after therapy was stopped. Whether a 3- to 4-week course of interleukin 2 therapy leads to an increased rate of seroconversion from HBeAg to antibody in chronic type B hepatitis deserves further evaluation in prospectively randomized, controlled trials.
TCT-629 Effect of the Absorb Bioresorbable Vascular Scaffold (BVS) on Coronary Plaque Regression in a Familial Hypercholesterolemic Swine: 1-Year Follow-Up
Authors: Qing Wang, LAURA E. Perkins, Alexander Sheehy, Jenn McGregor, Yanping Cheng, Carlos A. Gongora, Masahiko Shibuya, James J. Benham, Byron Lambert, Dan Cox, Greg L. Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2014)