tbuckley/cabot-search huggingface dataset:
Erratum: Corrigendum: The genome sequence of the orchid Phalaenopsis equestris
Authors: Jing Cai, Xin Liu, Kevin Vanneste, Sebastian Proost, Wen-Chieh Tsai, Ke-Wei Liu, Li-Jun Chen, Ying He, Qing Xu, Chao Bian, Zhijun Zheng, Fengming Sun, Weiqing Liu, Yu-Yun Hsiao, Zhao-Jun Pan, Chia-Chi Hsu, Ya-Ping Yang, Yi-Chin Hsu, Yu-Chen Chuang, Anne Dievart, Jean-Francois Dufayard, Xun Xu, Jun-Yi Wang, Jun Wang, Xin-Ju Xiao, Xue-Min Zhao, Rong Du, Guo-Qiang Zhang, Meina Wang, Yong-Yu Su, Gao-Chang Xie, Guo-Hui Liu, Li-Qiang Li, Lai-Qiang Huang, Yi-Bo Luo, Hong-Hwa Chen, Yves Van de Peer, Zhong-Jian Liu
Journal: Nature Genetics (2015)
Abstract 3521: B7-H3 associated with tumor progression and epigenetic regulatory activity in cutaneous melanoma.
Authors: Jinhua Wang, Kelly Chong, Sharon Huang, Dave Hoon
Journal: Cancer Research (2013)

Abstract B7-H3 is a transmembrane glycoprotein and a member of the B7/CD28 immunoglobulin superfamily which plays an important functional role in tumor surveillance by T-cells. High expression of B7-H3 has been related to a poor prognosis in some tumor types. Melanoma is the most aggressive form of skin cancer. B7-H3 expression was evaluated by RT-qPCR and IHC analysis on individual melanoma specimens and then verified in clinically annotated melanoma stage III and stage IV metastasis tissue microarrays(TMA) in a double blind study. B7-H3 mRNA expression was shown to be significantly increased with stage of melanoma(P&amp;lt;0.0001) and significantly associated with melanoma-specific survival(MSS) in both stage III(P&amp;lt;0.0001) and stage IV(P&amp;lt;0.012) melanoma patients. B7-H3 expression was related to migration and invasion of melanoma cells; overexpression B7-H3 increased migration and invasion while knockdown of B7-H3 reduced cell migration and invasion. MiR-29c expression was shown to inversely regulate B7-H3. Furthermore, we demonstrated that B7-H3 expression was related to p-STAT3 expression in melanoma. These results suggest B7-H3 may be a useful biomarker for melanoma progression and patients’ outcome. Citation Format: Jinhua Wang, Kelly Chong, Sharon Huang, Dave Hoon. B7-H3 associated with tumor progression and epigenetic regulatory activity in cutaneous melanoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3521. doi:10.1158/1538-7445.AM2013-3521
737. Induction of Molecular Chimerism in Rhesus Macaques Reconstituted with Autologous CD34+ Cells Transduced with the Gene Encoding the α(1-3)galactosyltranferase (αGT)
Authors: Lorenzo Benatuil, Robert Donahue, Aylin Bonifacino, Cynthia Dunbar, John Iacomini
Journal: Molecular Therapy (2005)

Background: Anti-donor antibodies remain a significant problem in discordant xenotransplantation, and are believed to play a significant role in chronic allograft rejection. We have previously shown that genetic engineering of autologous bone marrow stem cells to induce molecular chimerism can be used to establish B cell tolerance in mice. In this study, we examined whether a similar approach could be used to induce B cell tolerance in Rhesus macaques, a preclinical animal model. To this end, we investigated whether induction of molecular chimerism could be used to affect production of antibodies specific for the carbohydrate ep|[iacute]|tope Gal|[alpha]|1-3Gal|[beta]|1-4GlcNAc-R (|[alpha]|Gal).
P13 Interferon-gamma release assay (IGRA) conversion, reversion and implications for the diagnosis of latent tuberculosis infection using a multimodality approach: a retrospective, observational study within a central London TB centre
Authors: M. H. Almond, M. O'Donoghue, N. Drey, S. Seneviratne, A. Lalvani, M. Wickremasinghe, O. M. Kon
Journal: Thorax (2011)

<h3>Introduction and Objectives</h3> Accurate diagnosis &amp; management of latent tuberculosis infection (LTBI) among TB contacts is critical for both the health of infected individuals and prevention of disease transmission. Interferon gamma release assays (IGRAs) measure T cell release of interferon-gamma following stimulation by antigens not confounded by the BCG vaccination. The current NICE guidelines recommend their use following a positive TST. In addition some centres have moved to a single step IGRA test for LTBI. Our institution adopts a triple investigation approach comprising a chest radiograph (CXR), TST and IGRA on presentation followed by a rescreen if the TST &amp; IGRA are discordant or if pulmonary contacts are screened prior to 6 weeks. The aim of our study was to evaluate the prevalence of IGRA conversion and reversion in rescreened asymptomatic TB contacts that attended our centre. <h3>Methods</h3> This was a retrospective, observational study carried out at a central London teaching hospital. The study population comprised 593 consecutive, adult TB contacts screened between 1 January 2008 and 31 December 2010. Data were collected through retrospective review of chest radiographs, TST &amp; IGRA tests. <h3>Results</h3> Of 498 asymptomatic TB contacts screened, 460 had both an initial TST and IGRA performed (Abstract P13 figure 1). 81 (17.7%) contacts had discordant TST &amp; IGRA results. 52 (64%) of these discordant cases had a positive TST &amp; Negative IGRA; these patients would have been discharged under NICE guidelines however, our rescreen revealed 9 (17%) positive 2<sup>nd</sup> IGRAs that is, conversion. Three of these patients were under 35 and would therefore by eligible for chemoprophylaxis. Twenty-nine (36%) of the discordant cases had a negative TST and positive IGRA however, 8 (28%) of these IGRAs reverted to negative. It is important to note that if following a single-step IGRA screening protocol (ie, without a rescreen) these cases may have been commenced on chemoprophylaxis unnecessarily (four of these reversion cases were under the age of 35). <h3>Conclusions</h3> Our results show that adoption of either a sequential TST + ve/IGRA approach or single IGRA approach can result in a significant number of false negative LTBI diagnoses due to IGRA conversion. Conversely, we have also shown that an IGRA rescreen because of discordant TST/IGRA tests can improve LTBI diagnostic specificity and therefore reduce unnecessary chemoprophylaxis due to the effect of reversion.
Low-Fat Diet and Cardiovascular Disease
Authors: Dariush Mozaffarian
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tadalafil Alleviates Muscle Ischemia in Patients with Becker Muscular Dystrophy
Authors: Elizabeth A. Martin, Rita Barresi, Barry J. Byrne, Evgeny I. Tsimerinov, Bryan L. Scott, Ashley E. Walker, Swaminatha V. Gurudevan, Francine Anene, Robert M. Elashoff, Gail D. Thomas, Ronald G. Victor
Journal: Science Translational Medicine (2012)

The phosphodiesterase 5A inhibitor tadalafil restores normal blood flow regulation in exercising skeletal muscle of patients with Becker muscular dystrophy.
Tolrestat in the Primary Prevention of Diabetic Neuropathy
Authors: Dario Giugliano, Rita Acampora, Raffaele Marfella, Giosué Di Maro, Nicoletta De Rosa, Lucio Misso, Antonio Ceriello, Antonio Quatraro, Felice D'Onofrio
Journal: Diabetes Care (1995)

OBJECTIVE To compare the effects of tolrestat and placebo in patients with subclinical diabetic neuropathy. RESEARCH DESIGN AND METHODS Non-insulin-dependent diabetes mellitus (NIDDM) patients with early involvement of the autonomic nervous system were identified by only one pathological (outside the 99% confidence interval of the normal population) squatting test (vagal or sympathetic). Fifty-seven patients entered a randomized, placebo-controlled, double-blind, parallel 52-week study of tolrestat at a dose of 200 mg/day. Cardiovascular reflex tests (squatting vagal and sympathetic tests, pressure gain, deep breathing, lying-to-standing, Valsalva maneuver, and orthostatic hypertension), vibration thresholds, tendon reflexes, and muscle strength were assessed throughout the study. RESULTS At 12 months, nerve function significantly improved in patients receiving tolrestat and deteriorated in patients taking placebo. At baseline, the squatting vagal test was normal in 16 patients in the tolrestat group and in 15 patients in the placebo group. At 12 months, 25 patients taking tolrestat had a normalized squatting test, but only 6 patients taking placebo did (P = 0.02). Vibration perception threshold improved by a value of 6 ± 3 V in the tolrestat group (P &amp;lt; 0.001) and deteriorated by a value of 3 ± 1.8 V (P &amp;lt; 0.001) in the placebo group. CONCLUSIONS Tolrestat may be useful in the primary prevention of diabetic neuropathy.
Microcystic cyanobacteria causes mitochondrial membrane potential alteration and reactive oxygen species formation in primary cultured rat hepatocytes.
Authors: W X Ding, H M Shen, Y Shen, H G Zhu, C N Ong
Journal: Environmental Health Perspectives (1998)

Cyanobacteria contamination of water has become a growing public health problem worldwide. Microcystis aeruginosa is one of the most common toxic cyanobacteria. It is capable of producing microcystins, a group of cyclic heptapeptide compounds with potent hepatotoxicity and tumor promotion activity. The present study investigated the effect of microcystic cyanobacteria on primary cultured rat hepatocytes by examining mitochondrial membrane potential (MMP) changes and intracellular reactive oxygen species (ROS) formation in cells treated with lyophilized freshwater microcystic cyanobacteria extract (MCE). Rhodamine 123 (Rh-123) was used as a fluorescent probe for changes in mitochondrial fluorescence intensity. The mitochondrial Rh-123 fluorescence intensity in MCE-treated hepatocytes, examined using a laser confocal microscope, responded in a dose- and time-dependent manner. The results thus indicate that the alteration of MMP might be an important event in the hepatotoxicity caused by cyanobacteria. Moreover, the parallel increase of ROS formation detected using another fluorescent probe, 2',7'-dichlorofluorescin diacetate also suggests the involvement of oxidative stress in the hepatotoxicity caused by cyanobacteria. The fact that MMP changes precede other cytotoxic parameters such as nuclear staining by propidium iodide and cell morphological changes suggests that mitochondrial damage is closely associated with MCE-induced cell injury in cultured rat hepatocytes.
Effect of secretogogues on mucosal blood flow in the antrum and corpus of the stomach.
Authors: T V Taylor, B R Pullan, J Goddard, B Torrance
Journal: Gut (1978)

Gastric mucosal blood flow in the rat was determined by the indicator fractionation technique of Sapirstein using Rb86Cl. Antral and corpus flow rates were determined in response to increasing doses of pentagastrin and histamine and the effect of vagotomy was determined. With progressive stimulation the antral:corpus flow ratio increased with both stimulants; however, vagotomy and noradrenaline reduced blood flow in both areas of mucosa. It is concluded that the antrum, as well as the corpus, actively responds to secretory stimulants by an increase in mucosal blood flow and support is provided for the theory that the antrum plays an active role in the control of parietal cell blood flow and secretion.
The hepatic microcirculation in the isolated perfused human liver
Authors: J Villeneuve, M Dagenais, P Huet, A Roy, R Lapointe, D Marleau
Journal: Hepatology (1996)

In cirrhosis, capillarization of sinusoids could result in impaired exchanges between the hepatocytes and the blood perfusing the liver and contribute to liver failure irrespective of the metabolic capacity of the liver. To characterize anomalies of the hepatic microcirculation, we used the multiple-indicator dilution approach in isolated perfused livers obtained from patients with cirrhosis at the time of transplantation, and from organ donors with normal or near-normal livers or hepatic steatosis. In organ donors, the sinusoidal volume and the permeability of sinusoids to albumin, sucrose, and water were found to be comparable to that of normal dog and rat livers. The sinusoidal volume and the extravascular volume (EVV) accessible to diffusible tracers were larger after hepatic artery than after portal vein injection, probably because of an unshared arterial sinusoidal bed. In cirrhotic livers, two kinds of alterations were found: the appearance of a barrier between the sinusoids and the hepatocytes (capillarization) and intrahepatic shunts. The extravascular space accessible to albumin decreased with increasing severity of cirrhosis, and the diffusion of sucrose in the space of Disse showed a barrier-limited pattern, instead of the normal flow-limited behavior. In cirrhotic livers, a correlation was found between the hepatic extraction of indocyanine green (ICG) and the extravascular space accessible to albumin ( r = .84, P &lt; .05), suggesting that the impaired access of this protein-bound dye to the hepatocyte surface contributed to its impaired elimination. Intrahepatic shunts were found between portal and hepatic vein (21% ± 16% of portal flow), but not between hepatic artery and hepatic veins. We conclude that (1) the behavior of diffusible tracers in human livers with normal liver architecture is comparable to that reported in normal animals; (2) the permeability of sinusoids in cirrhotic livers is abnormal, (3) permeability changes are related to changes in liver function in cirrhosis.
Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay
Authors: Orathai Jirapongsananuruk, Harry L. Malech, Douglas B. Kuhns, Julie E. Niemela, Margaret R. Brown, Mindy Anderson-Cohen, Thomas A. Fleisher
Journal: Journal of Allergy and Clinical Immunology (2003)
Work-related asthma and implications for the general public.
Authors: Edward L Petsonk
Journal: Environmental Health Perspectives (2002)

Asthma has been increasing over the last two decades in the United States. The onset of asthma has also been increasingly reported as a result of occupational exposures to over 350 different agents. Work-related asthma (WRA) has become the most frequently diagnosed occupational respiratory illness. Epidemiologic studies from the United States reported WRA incidence rates of 29-710 cases per million workers per year and suggest that 10-25% of adult asthma is work related. Much can be learned about asthma in the general population from investigations of asthma in the workplace. Surveillance of WRA continues to highlight an important role for low molecular weight chemical sensitizers, as well as high molecular weight antigens. Additionally, recent reports implicate mixed exposures, including commercial cleaning solutions, solvents, and other respiratory irritants, as well as contamination in nonindustrial environments, including schools and offices. Investigations of WRA have demonstrated a clear dose-related increase in sensitization and symptoms for exposures to both chemical and protein sensitizers. High proportions of exposed working groups can be affected. Skin exposures may affect the likelihood of individuals developing respiratory symptoms. Atopy increases the risk of sensitization and illness from workplace exposure to antigens but not to chemical sensitizers. Irritant exposures can act as adjuvants among individuals exposed to sensitizing substances, increasing the proportion who become sensitized. Atopy might also be a result of irritant exposures in some persons. Occupational asthma often has important long-term adverse health and economic consequences but can resolve completely with timely control of exposures. Detailed study of such asthma "cures" may prove useful in understanding factors that influence asthmatic airway inflammation in the general population.
Children’s Exposure to Testosterone Gel Spurs FDA to Order Boxed Label Warning
Authors: Rebecca Voelker
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence
Authors: Michael Lie-A-Ling, Elli Marinopoulou, Yaoyong Li, Rahima Patel, Monika Stefanska, Constanze Bonifer, Crispin Miller, Valerie Kouskoff, Georges Lacaud
Journal: Blood (2014)
Abstract LB-170: A role of sphingosine kinase 1 in peritoneal macrophages on the early stages of colon carcinogenesis
Authors: Toshihiko Kawamori, Hideki Furuya, Yoshiko Shimizu, Paulette M. Yamada
Journal: Cancer Research (2012)

Abstract Our previous studies indicate that the Sphingosine kinase 1 (SphK1)/Sphingosine 1-phosphate (S1P) pathway mediates colon carcinogenesis at least by regulating COX-2 expression and prostaglandin E2 (PGE2) production. However, the mechanisms by which this pathway regulates colon carcinogenesis are still unclear. First, we show that SphK1 deficient mice significantly attenuated azoxymethane (AOM)-induced colon carcinogenesis as measured by colon tumor incidence, multiplicity, and volume. We found that AOM activates peritoneal macrophages to induce SphK1, COX-2, and TNF-α expression in WT mice. Interestingly, SphK1 KO mice revealed significant reduction of COX-2 and TNF-α expression from AOM-activated peritoneal macrophages, suggesting that SphK1 regulates COX-2 and TNF-α expression in peritoneal macrophages. Finally, we found that inoculation of WT peritoneal macrophages “rescued” the carcinogenic effect of AOM in Sphk1 KO mice as measured by aberrant crypt foci (ACF) formation, preneoplastic lesions of colon cancer, indicating that SphK1 expression in peritoneal macrophages is required in the early stages of colon carcinogenesis when induced by AOM. These results suggest that SphK1 expression plays a pivotal role in the early stages of colon carcinogenesis through regulating COX-2 and TNF-α expression from activated peritoneal macrophages. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-170. doi:1538-7445.AM2012-LB-170
Intestinal Scleroderma With Malabsorption
Authors: Ernest Atlas
Journal: JAMA (1968)

To the Editor:—  I was very much interested in the report by Meihoff et al, Small Intestinal Scleroderma With Malabsorption and Pneumatosis Cystoides Intestinalis ( 204 : 854,1968). While a resident in medicine at the University of Washington Hospitals I had the opportunity of caring for an identical case. I should appreciate the opportunity of reporting this third case of the association between scleroderma with small intestinal involvement, malabsorption, and the presence of gas in the wall of the intestine known as pneumatosis cystoides intestinalis.  Report of a Case:—  A 40-year-old white woman was referred to the University of Washington Hospitals for evaluation and therapy of scleroderma. She had first noted the onset of blanching of the fingertips with exposure to cold some 22 years ago. This gradually progressed to deep cyanosis and ulcerations. Ten years later she first noted a feeling of tightness in her throat with some difficulty swallowing. Gastrointestinal
Endobronchial Metastasis of Uterine Leiomyosarcoma
Authors: James C. Giudice
Journal: JAMA (1979)

<h3>To the Editor.—</h3> A recent article published inThe Journalon the endobronchial metastasis of uterine leiomyosarcoma (240:2080, 1978) prompted us to report a similar case in which the patient sustained a massive hemoptysis. <h3>Report of a Case.—</h3> A 56-year-old woman was admitted to our hospital with progressive hemoptysis of approximately one week's duration and that certainly was properly classified as massive<sup>1</sup>in description. Her condition had been diagnosed as uterine leiomyosarcoma approximately one year before at the University of Pennsylvania. A total abdominal hysterectomy was performed, and the patient was relatively free of symptoms until approximately one month before admission. The admission chest roentgenogram was clearly abnormal with multiple nodules consistent with metastatic disease. Fiberoptic bronchoscopy was performed on the second hospital day, and bleeding polypoid lesions were noted in the superior segment of the right lower lobe and the lateral segment of the right middle lobe. Because
RELATIVE CONTRIBUTION OF AFTERLOAD AND INTERSTITIAL TISSUE FIBROSIS TO PREOPERATIVE LONGITUDINAL FUNCTION IN PATIENTS WITH SEVERE AORTIC STENOSIS: IMPLICATIONS FOR POSTOPERATIVE FUNCTIONAL RECOVERY
Authors: Julie Melchior, Sophie Pierard, Stephanie Seldrum, Caroline Bouzin, Christophe de Meester de Ravenstein, Frédéric Maes, Agnes Pasquet, Anne-Catherine Pouleur, David Vancraeynest, Bernhard Gerber, Gebrine El Khoury, Sophie Minjauw, Jean-Louis Vanoverschelde
Journal: Journal of the American College of Cardiology (2013)
The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation
Authors: Irma Isordia-Salas, Robin A. Pixley, Hemant Parekh, Satya P. Kunapuli, Fengling Li, Anthony Stadnicki, Yingzhang Lin, R. Balfour Sartor, Robert W. Colman
Journal: Blood (2003)