tbuckley/cabot-search huggingface dataset:
Abstract 2240: TERT promoter mutations are highly prevalent in bladder cancer and represent a potential new urinary biomarker
Authors: Carolyn D. Hurst, Fiona M. Platt, Margaret A. Knowles
Journal: Cancer Research (2014)

Abstract Somatic mutation of the promoter region of the telomerase reverse transcriptase (TERT) gene was recently reported as a potential mechanism by which telomerase becomes activated in cancer cells. Here, we aimed to assess the frequency and spectrum of TERT promoter mutations in bladder cancer and detect mutations in voided urine. A SNaPshot assay designed to simultaneously interrogate two positions (-124bp and -146bp) previously reported as mutated in melanoma was used to screen 47 bladder cancer cell lines and 262 tumors. Forty cell lines and 201 tumors carried mutations at either -124bp or -146bp. Mutations at these positions were mutually exclusive. A germline mutation at -57bp (T&amp;gt;G) was previously reported in a melanoma-prone family. A second SNaPshot assay was designed to interrogate position -57bp and we screened all samples that were wildtype at positions -124bp and -146bp. Mutations at -57bp were detected in two cell lines and eight tumors. Matched blood samples were available for six of the tumors and one cell line, and somatic mutation status was confirmed. Sanger sequencing of the TERT core promoter in samples that were wildtype at positions -57bp, -124bp and -146bp revealed a further nine somatic mutations. Four mutations at positions -45bp, -72/-77bp, -141bp, and -54bp were novel, and all but one (-54bp) created new binding sites for ETS/TCF transcription factors. Overall, TERT promoter mutations were detected in 89% of cell lines and 83% of tumors. There was no association of TERT promoter mutation status with stage (p=0.1089, chi-square test) or grade (p=0.2438, chi-square test). As mutations are highly frequent in both non-muscle-invasive and invasive bladder cancer, these represent potential biomarkers for urine-based disease monitoring. For sixty-four tumors used in this study, matched urine samples were also collected prior to surgery. Fifty-three of the tumors had mutations at -124bp or -146bp and using the -124bp/-146bp SNaPshot assay we were able to detect 51 of these in the corresponding urine samples including all mutations (n=23) in 29 patients with low-grade noninvasive tumors. The use of TERT promoter mutation analysis in combination with other DNA-based biomarkers could markedly improve the sensitivity for urine-based detection of recurrent disease. Citation Format: Carolyn D. Hurst, Fiona M. Platt, Margaret A. Knowles. TERT promoter mutations are highly prevalent in bladder cancer and represent a potential new urinary biomarker. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2240. doi:10.1158/1538-7445.AM2014-2240
The stagnation of left atrial appendage blood during sinus rhythm in patients with transient atrial fibrillation assessed by transpulmonary contrast echocardiography
Authors: Shiro Izumi, Tetsuro Ohta, Shigeo Kobayashi, Hiromi Shimizu, Shigenori Ishikawa, Hiroshi Nosaka
Journal: Journal of the American College of Cardiology (1996)
Aspartame and its effects on health: Approach seems simplistic in electronic responses to editorial
Authors: Nick Finer
Journal: BMJ (2005)

Save the FDAEditor-Abbasi asks whether drug regulation is failing. 1 The US Food and Drug Administration (FDA) performs a thankless task.Patients want new drugs available immediately and agitate to accomplish this.Patients also wish medicines to be guaranteed safe, and blame the FDA when toxicity leads to a drug's withdrawal.Clinical scientists complain that the FDA obstructs their investigations.Pharmaceutical companies see the FDA as an adversary, not a protector.Practising in the USA for 20 years, I encountered many FDA agents.A few revered regulations for their own sake.Such people are irksome, but without strict oversight valueless and toxic agents would be marketed.A prime example is Laetrile (laevo-mandelonitrile-beta-glucuronoside), a useless and poisonous drug promoted for cancer treatment.The FDA, supported by the National Cancer Institute, successfully resisted extreme public pressure to allow its marketing, saving many lives and a multimillion dollar fraud.The FDA faces serious accusations.Attempting to suppress David Graham's whistleblowing on rofecoxib assaults scientific honesty. 2 3 The FDA's refusal to allow non-prescription sales of emergency contraception indicates unacceptable political pressure from the religious right.Unduly close relations between the FDA and pharmaceutical companies may lead to premature marketing approvals.How should the FDA be saved?Firstly, officials ordering withdrawal of a drug should be independent of those who approve marketing.Secondly, making the FDA a quango would protect from political pressures.Thirdly, conflicts of interest involving FDA employees and consultants must be rigorously scrutinised, even more severely than editors scrutinise the interests of contributors.The UK's Medicines and Healthcare products Regulatory Agency is accused of proindustry bias.Housecleaning there and at the FDA will benefit patients, doctors, and the pharmaceutical industry itself.
The DC-SIGN–related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells
Authors: Angeles Dominguez-Soto, Laura Aragoneses-Fenoll, Enrique Martin-Gayo, Lorena Martinez-Prats, Maria Colmenares, Marisa Naranjo-Gomez, Francesc E. Borras, Pilar Munoz, Mercedes Zubiaur, Maria L. Toribio, Rafael Delgado, Angel L. Corbi
Journal: Blood (2007)
"SOME COMPARATIVE RESULTS IN CITIES AND IN COUNTIES AS HEALTH UNITS"
Authors: L. L. Lumsden
Journal: JAMA (1922)

<h3>To the Editor:</h3> —The article of Dr. A. J. Warren on "Some Comparative Results in Cities and in Counties as Health Units" (The Journal, July 29, 1922, p. 362) should be of general interest because of the importance of careful consideration of the economic principles involved in public health work. It is of especial interest to me because the author twists into the theme of his paper a quotation from one of my official reports in such a way as to furnish a basis for radical misunderstanding of my attitude toward rural health work. If it were discovered that, in general, rural health work can be conducted at relatively<i>less</i>cost than urban health work of equivalent degree, I should be glad to accept the discovery and use it for whatever it might be worth in the advocacy of county health work. Therefore, my statement that "rural health work, on
Functional and Morphological Imaging of Extraadrenal Myelolipoma
Authors: Stefan Adams, Dieter Liermann, Stefan Mruck
Journal: Clinical Nuclear Medicine (2009)

Myelolipoma is a rare, hormonally inactive, benign tumor consisting of fat and hematopoietic cells. It is often encountered in the adrenal gland. Less frequently, it may occur in extraadrenal sites. Although myelolipoma is well defined by criteria of morphologic imaging, functional characteristics may be crucial to exclude malignancy. We present a case of histologically proven extraadrenal myelolipoma which was successfully diagnosed by bone marrow scintigraphy, using a monoclonal antibody directed against myeloid elements.
Different Patterns for Bile Leakage Following Cholecystectomy Demonstrated by Hepatobiliary Imaging
Authors: ASLAM R. SIDDIQUl, JAMES H. ELLIS, JAMES A. MADURA
Journal: Clinical Nuclear Medicine (1986)

Tc-99m labeled iminodiacetic acid (Tc-99m IDA) studies were performed in three patients with bile leaks. The radiotracer distribution was different in all three. A diffuse peritoneal pattern was seen in one patient. Localized radioactivity was seen in two; in one in the gallbladder bed and in the other in the perihepatic region.
The Bittersweet Fruit of the Knowledge Tree
Authors: Samuel Vaisrub
Journal: JAMA (1979)

It is becoming increasingly difficult to fool some of the people even some of the time unless, of course, one peddles an arthritis cure or a megavitamin panacea. It is especially difficult to fool patients with advanced cancer about the nature and prognosis of their disease. Some of the causes of this difficulty—wide dissemination of information by the media, obvious implications of chemotherapy, and fear of litigation—are discussed at length by Novack et al (p 897) and by Freireich (on this page).  Clearly, there is no arguing with reality. Practical obstacles to withholding the unwelcome truth from cancer patients are often insurmountable. What is open to argument, however, are the philosophic considerations frequently put forth in defense of complete, frank disclosures. Most of these considerations are based on the aura of sanctity that enshrouds truth, be it the revealed truth of the Scriptures or the no less devoutly worshipped truth
SPILLED GALLSTONES AT LAPAROSCOPIC CHOLECYSTSECTOMY – A REASON FOR RE-OPERATION IN THOSE WITH INCIDENTAL GALLBLADDER CANCER?
Authors: A I W Mayne, J Ahmad, C Jones, B V Dasari, L D McKie, T Diamond, M Loughrey, M A Taylor
Journal: Gut (2013)

<h3>Introduction</h3> Laparoscopic Cholecystectomy is the gold standard treatment of symptomatic gallstone disease. Incidental gallbladder cancer is found in 0.6–2.1% of cases. Patients with Tis or T1a tumours generally undergo no further intervention. We present a case report and suggest the need for an aggressive management approach in patients with incidental Tis or T1a gallbladder cancer who had spilled stones at primary laparoscopic cholecystectomy. <h3>Method</h3> A 37 year-old lady underwent a laparoscopic cholecystectomy for symptomatic gallstone disease. At operation, a number of gallstones were spilled into the peritoneal cavity. Subsequent histological examination showed an incidental pT1a gallbladder cancer, with areas of high grade dysplasia. HPB MDM discussion agreed on regular six-monthly outpatient follow-up. The patient re-presented to outpatient clinic 2 years later with recurrent right upper quadrant pain. Computed Tomography imaging revealed a small lesion in segment 6 of the liver. The patient underwent a diagnostic laparotomy which found multiple metastatic deposits, which on histological examination, were felt to have derived from the spilled gallstones at initial laparoscopic cholecystectomy. Due to the multiple metastatic deposits, the disease was un-resectable and she is to be treated with palliative chemotherapy. <h3>Results</h3> Spilled gallstones occur in around 5-7% of laparoscopic cholecystectomies. There is a paucity of literature on the management of patients with spilled gallstones who subsequently are found to have incidental gallbladder cancer. Gallbladder cancers stage Tis or T1a have a favourable prognosis and are normally treated with simple cholecystectomy alone but this case has demonstrated a devastating outcome to this management approach. <h3>Conclusion</h3> We suggest an aggressive management approach to patients with spilled gallstones who are subsequently found to have low grade Gallbladder Cancer.
Treatment of a Submucosal Hemangioma of the Esophagus Using Simultaneous Video-Assisted Thoracoscopy and Esophagoscopy: Description of a New Minimally Invasive Technique
Authors: O. J. Rämö, J. A. Salo, R. Bardini, A. T. Nemlander, M. Färkkilä, S. P. Mattila
Journal: Endoscopy (1997)
Audible Auricular Heart Sounds in Auricular Flutter
Authors: John P. Rattigan, William W. Byrnes, Henry Kraus, Herbert S. Sise
Journal: New England Journal of Medicine (1952)

THE bedside diagnosis of auricular flutter can occasionally be made on the basis of certain characteristics of the ventricular rate and its response to carotid-sinus pressure, deep inspiration and exercise, changing intensity of the first heart sound (especially when the ventricular response is irregular) and rapid auricular undulations in the neck veins. Less frequently but more conclusively the diagnosis can be established by the presence of audible auricular heart sounds at the precordium.Instances of auricular flutter in which auricular sounds have been heard and recorded by graphic methods are rare. In their excellent review of this subject, Hecht and . . .
Shift resources and focus from psychiatric beds to the community
Authors: S. Rathod, D. Kingdon, B. Nausheen
Journal: BMJ (2011)

Tyrer’s case for a moratorium on or even an increase in the number of psychiatric beds seems to be primarily based on the current poor care in units, lack of continuity, and increased risks to service users.1 However, as Johnson says,2 the evidence that risk …
Current Therapy in Allergy and Immunology 1983-84
Authors: Sonya Naryshkin
Journal: JAMA (1984)

<i>Current Therapy in Allergy and Immunology 1983-1984</i>is a guide for the physician treating patients with diagnosed diseases having allergic or immunologic bases. Also included are diseases of probable immunologic origin such as multiple sclerosis. This book is part of a series of "current therapy" books for which periodic updates are planned. The editors explain in the preface that their aim is to provide a concise and thorough guideline to the treatment of allergic and immunologic disorders. Because of the rapid changes in this field, notable differences of opinion concerning treatment regimens, and the chronic and recurrent nature of many of these diseases that make interpretation of therapeutic studies difficult, summaries of the literature can be confusing. References have therefore been purposely omitted. Instead, 91 widely recognized clinical investigators, active in the study and treatment of the diseases concerned, have been chosen to discuss the approaches they themselves take in
The doctor in the house diagnoses flux and frustration
Authors: D. L. Breo
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hereditary hemochromatosis and red cell aplasia
Authors: Paul C. Adams
Journal: American Journal of Hematology (1994)

Abstract A 63‐year‐old white man with myasthenia gravis and red cell aplasia was found to have hepatic iron overload. The differential diagnosis included hereditary hemochromatosis and secondary iron overload related to red cell aplasia. Family studies of siblings, including HLA typing, initially suggested a diagnosis of secondary iron overload. The investigation of a remote sibling led to the final diagnosis of hereditary hemochromatosis. The case illustrates the importance of complete family investigations in the differentiation between hereditary hemochromatosis and secondary iron overload and the potential hazard of using HLA typing as an indirect genetic test for hereditary hemochromatosis. © 1994 Wiley‐Liss, Inc.
Remarks ON CERTAIN INJURIES COMMONLY ASSOCIATED WITH DISPLACEMENT OF THE HEAD OF THE HUMERUS: Illustrated by a Series of Twenty-six Skiagraphs
Authors: R. Jones
Journal: BMJ (1906)

IN my experience the most common complication of fracture of the upper end of the humerus is dislocation of the shoulder.I find I have twenty-two radiographs taken of my own cases where this complication is depicted, and I can recollect in addition at least four cases where the diagnosis was obvious, but the condition of the patient would not allow of an examination by means of x rays.On three occasions when consulted regarding a fracture through the surgical neck, I have been told by the practitioner that the dislocated head had been present and had been reduced.Before Roentgen's discovery, both in the exceptionally large practice of H. 0. Thomas and in my own, I can recall several fractures of the neck complicated by dislocations of the humerus.In order of frequency, I would tabulate fractures of the shoulder connected with dislocation as follows:
Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis.
Authors: A E Koch, S L Kunkel, L A Harlow, D D Mazarakis, G K Haines, M D Burdick, R M Pope, A Walz, R M Strieter
Journal: Journal of Clinical Investigation (1994)

We and others have shown that cells obtained from inflamed joints of rheumatoid arthritis (RA) patients produce interleukin-8, a potent chemotactic cytokine for neutrophils (PMNs). However, IL-8 accounted for only 40% of the chemotactic activity for PMNs found in these synovial fluids. Currently, we have examined the production of the novel PMN chemotactic cytokine, epithelial neutrophil activating peptide-78 (ENA-78), using peripheral blood, synovial fluid, and synovial tissue from 70 arthritic patients. RA ENA-78 levels were greater in RA synovial fluid (239 +/- 63 ng/ml) compared with synovial fluid from other forms of arthritis (130 +/- 118 ng/ml) or osteoarthritis (2.6 +/- 1.8 ng/ml) (P < 0.05). RA peripheral blood ENA-78 levels (70 +/- 26 ng/ml) were greater than normal peripheral blood levels (0.12 +/- 0.04 ng/ml) (P < 0.05). Anti-ENA-78 antibodies neutralized 42 +/- 9% (mean +/- SE) of the chemotactic activity for PMNs found in RA synovial fluids. Isolated RA synovial tissue fibroblasts in vitro constitutively produced significant levels of ENA-78, and this production was further augmented when stimulated with tumor necrosis factor-alpha (TNF-alpha). In addition RA and osteoarthritis synovial tissue fibroblasts as well as RA synovial tissue macrophages were found to constitutively produce ENA-78. RA synovial fluid mononuclear cells spontaneously produced ENA-78, which was augmented in the presence of lipopolysaccharide. Immunohistochemical localization of ENA-78 from the synovial tissue of patients with arthritis or normal subjects showed that the predominant cellular source of this chemokine was synovial lining cells, followed by macrophages, endothelial cells, and fibroblasts. Synovial tissue macrophages and fibroblasts were more ENA-78 immunopositive in RA than in normal synovial tissue (P < 0.05). These results, which are the first demonstration of ENA-78 in a human disease state, suggest that ENA-78 may play an important role in the recruitment of PMNs in the milieu of the inflamed joint of RA patients.
Partial nasal reconstruction with titanium mesh: report of five cases
Authors: M.A. Rodríguez-Prieto, A. Pérez-Bustillo, T. Alonso-Alonso, P. Sánchez-Sambucety
Journal: British Journal of Dermatology (2009)

Journal Article Partial nasal reconstruction with titanium mesh: report of five cases Get access M.A. Rodríguez‐Prieto, M.A. Rodríguez‐Prieto Department of Dermatology, Complejo Asistencial de León, Altos de Nava s/n, 24071 León, Spain Search for other works by this author on: Oxford Academic Google Scholar A. Pérez‐Bustillo, A. Pérez‐Bustillo Department of Dermatology, Complejo Asistencial de León, Altos de Nava s/n, 24071 León, Spain Correspondence: A. Pérez‐Bustillo. E‐mail: aliciapebus@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar T. Alonso‐Alonso, T. Alonso‐Alonso Department of Dermatology, Complejo Asistencial de León, Altos de Nava s/n, 24071 León, Spain Search for other works by this author on: Oxford Academic Google Scholar P. Sánchez‐Sambucety P. Sánchez‐Sambucety Department of Dermatology, Complejo Asistencial de León, Altos de Nava s/n, 24071 León, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 161, Issue 3, 1 September 2009, Pages 683–687, https://doi.org/10.1111/j.1365-2133.2009.09257.x Published: 01 September 2009
Enabling like minded GPs to group together to provide and commission care
Authors: D. Albert
Journal: BMJ (2014)

The Royal College of General Practitioners, in proposing GP federations, and the King’s Fund, in proposing family care networks, are on the right track.1 But they are also repeating a mistake of the past: creating new organisations to muddle alongside existing ones, as when practice based commissioning consortiums ran alongside primary care trusts.

GP practices …
Hospital Readmissions in the Medicare Population
Authors: Gerard F. Anderson, Earl P. Steinberg
Journal: New England Journal of Medicine (1984)

Abstract In order to examine the proportion of Medicare expenditures attributable to repeated admissions to the hospital, we assessed the frequency with which 270,266 randomly selected Medicare beneficiaries were readmitted after hospital discharge between 1974 and 1977. Twenty-two per cent of Medicare hospitalizations were followed by a readmission within 60 days of discharge. Medicare spent over $2.5 billion per year (24 per cent of Medicare inpatient expenditures) on such readmissions between 1974 and 1977. Analogous expenditures in 1984 could approach $8 billion. Even a small decrease in the readmission rate could result in substantial savings for the Medicare program. The recently enacted prospective-payment legislation, however, creates economic incentives that could increase readmission rates. Attempts by professional review organizations or others to develop hospital readmission profiles will need to control for patient and hospital characteristics that are correlated with the likelihood of readmission. Further study of such characteristics could help identify high-risk patient groups for whom increased outpatient supports might prove cost effective. (N Engl J Med 1984; 311:1349–53.)
Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells
Authors: Nathalie Fiegler, Sonja Textor, Annette Arnold, Alexander Rölle, Ina Oehme, Kai Breuhahn, Gerhard Moldenhauer, Mathias Witzens-Harig, Adelheid Cerwenka
Journal: Blood (2013)