Digital Necrosis and Disseminated Pneumocystis carinii Infection after Aerosolized Pentamidine Prophylaxis
Authors: Richard T. Davey
Journal: Annals of Internal Medicine (1989)

Brief Reports15 October 1989Digital Necrosis and Disseminated Pneumocystis carinii Infection after Aerosolized Pentamidine ProphylaxisRichard T. Davey Jr, MD, David Margolis, MD, David Kleiner, MD, Lawrence Deyton, MD, William Travis, MDRichard T. Davey Jr, MD, David Margolis, MD, David Kleiner, MD, Lawrence Deyton, MD, William Travis, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-8-681 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPneumocystis carinii pneumonia occurs with unusually high frequency in patients with human immunodeficiency virus (HIV) infection and contributes substantially to the morbidity and mortality associated with the acquired immunodeficiency syndrome (AIDS). A feature of infection with this pathogen is that disease is almost always confined to the lung, with extrapulmonary spread rarely reported. As a result, recent strategies to prevent pneumocystis infection without causing systemic toxicity have focused on aerosolized drug delivery to the lungs (1).In 1982, a 26-year-old heterosexual male developed stage III testicular germ cell malignancy that was treated with orchiectomy and combination chemotherapy. He did well...References1. GoldenChernoffHollanderFeigalConte JDHDJ. Prevention of Pneumocystis carinii pneumonia by inhaled pentamidine. Lancet. 1989;1:654-7. CrossrefMedlineGoogle Scholar2. AfessaGreenWilliams BWW. Pneumocystis carinii pneumonia complicated by lymphadenopathy and pneumothorax. Arch Intern Med. 1988;148:2651-4. CrossrefMedlineGoogle Scholar3. UngerRosenblumKrown PMS. Disseminated Pneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. Hum Pathol. 1988;19:113-6. CrossrefMedlineGoogle Scholar4. GrimesLaPookBarWassermanDwork MJMHA. Disseminated Pneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. Hum Pathol. 1987;18:307-8. CrossrefMedlineGoogle Scholar5. MacherBardensteinZimmerman ADL. Pneumocystis carinii choroiditis in a male homosexual with AIDS and disseminated pulmonary and extrapulmonary P. carinii infection [Letter]. N Engl J Med. 1987;316:1092. CrossrefMedlineGoogle Scholar6. VogelzangBoslJohnsonKennedy NGKB. Raynaud's phenomenon: a common toxicity after combination chemotherapy for testicular cancer. Ann Intern Med. 1981;95:288-92. LinkGoogle Scholar7. KovacsMasur JH. Pneumocystis carinii pneumonia: therapy and prophylaxis. J Infect Dis. 1988;158:254-9. CrossrefMedlineGoogle Scholar8. Hopewell P. Pneumocystis carinii pneumonia: diagnosis. J Infect Dis. 1988;157:1115-9. CrossrefMedlineGoogle Scholar9. WalzerPerlKrogstadRawsonSchultz PDDPM. Pneumocystis carinii pneumonia in the United States. Epidemiologic, diagnostic, and clinical features. Ann Intern Med. 1974;80:83-93. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Richard T. DaveyJr, MD; David Margolis, MD; David Kleiner, MD; Lawrence Deyton, MD; William Travis, MDAffiliations: From the National Institute of Allergy and Infectious Diseases and the National Cancer Institute, Bethesda, Maryland. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExtrapulmonary Pneumocystis jirovecii Infection in an Immunocompromised Patient With Concomitant Cytomegalovirus Reactivation: A Case Report and Literature ReviewDisseminated Pneumocystosis in a Toy PoodleTumor-Like Lesions of the Hepatobiliary Tract Caused by Fungal InfectionsTumor-like Lesions of the Hepatobiliary Tract Caused by Fungal InfectionsBrain Abscesses in HIV-Positive Patients due to Pneumocystis jiroveciProtozoaPneumocystis jiroveci PneumoniaVasculitisPneumocystis jiroveci thyroiditis: report of 15 cases in the literatureDual Infection with Mycobacterium tuberculosis and Pneumocystis jiroveci Lymphadenitis in a Patient with HIV Infection: Case Report and Review of the LiteratureFungal Infections of the Gastrointestinal TractDetection of Pneumocystis carinii DNA in Blood Specimens from Human Immunodeficiency Virus-Infected Patients by Nested PCRHyperthyroidism Due to Lymphoma Involving the Thyroid Gland in a Patient with Acquired Immunodeficiency Syndrome: Case Report and Review of the LiteraturePneumocystis carinii Meningoradiculitis in a patient with AIDSCentral Nervous System Pneumocystosis in a Patient with AIDSExtrapulmonary pneumocystosisSkin Involvement With Pneumocystis Despite Dapsone Prophylaxis:A Rare Cause of Skin Nodules in a Patient With AIDSSkin Involvement With Pneumocystis Despite Dapsone Prophylaxis: A Rare Cause of Skin Nodules in a Patient With AIDSPNEUMOCYSTIS CARINIICutaneous Pneumocystis carinii and Cryptococcus neoformans in AIDSCutaneous Pneumocystis carinii and Cryptococcus neoformans in AIDSCase 3-1995AIDS und HIV-InfektionPulmonary manifestations of acquired immunodeficiency syndromeVasculitisIntroduction to AIDS PathologyA Randomized Comparison of Once-monthly or Twice-monthly High-dose Aerosolized Pentamidine ProphylaxisGeneral PathologyPneumocystis cariniiDisseminated Pneumocystosis Presenting as a Pleural EffusionPneumocystis carinii Pneumonia Presenting as an Upper Lobe Cavity after Aerosolized Pentamidine Prophylaxis in an HIV-infected PatientDigital gangrene following chemotherapy for aids-related Kaposi's sarcomaCutaneous Pneumocystis carinii Infection Mimicking Kaposi SarcomaMargaret A. Litwin, MD, Carmen Myrie Williams, MDAcquired Immunodeficiency SyndromeTherapie der Infektionssyndrome bei AIDS und HIV-InfektionPneumocystis carinii in fna of the thyroidContemporary approaches in aerosolized drug delivery to the lungCase Report: Hypothyroidism Due to Pneumocystis Carinii Thyroiditis in a Patient with Acquired Immunodeficiency SyndromeBacterial, Viral, Fungal, and Parasitic Infections in HIV Disease and AIDSPneumocystis carinii pleuropneumonia after aerosolized pentamidine prophylaxisExtrapulmonary pneumocytosis in AIDSDisseminated Histoplasmosis Presenting as an Ulcerated Verrucous Plaque in a Human Immunodeficiency Virus-Infected Man.Aids und HIV-InfektionDissemination of Pneumocystis carinii in Patients with AIDSAtypical Presentations of Pneumocystis carinii Pneumonia in Patients Receiving Inhaled Pentamidine ProphylaxisAcquired Immunodeficiency SyndromePneumocystis Carinii Choroiditis After Long-Term Aerosolized Pentamidine TherapyExperience with Home Aerosolized Pentamidine Treatment in Patients with AidsTherapie der Lungenkrankheiten bei AidsEXTRAPULMONARY PNEUMOCYSTOSIS IN PATIENTS TAKING AEROSOLISED PENTAMIDINE 15 October 1989Volume 111, Issue 8Page: 681-682KeywordsAIDSAllergy and immunologyInfectious diseasesLungsPathogensPneumocystisPneumocystis carinii pneumoniaProphylaxisResearch laboratoriesToxicity ePublished: 1 December 2008 Issue Published: 15 October 1989 PDF downloadLoading ...