tbuckley/cabot-search huggingface dataset:
Thalidomide‐associated hepatitis: A case report
Authors: Robert Fowler, Kevin Imrie
Journal: American Journal of Hematology (2001)

Abstract We report a case of hepatitis in a 58‐year‐old woman being treated with thalidomide for end‐stage plasma cell leukemia. The patient had a medical history including chronic stable hepatitis C infection. At diagnosis there was a severe anemia, thrombocytopenia, hypercalcemia, IgG paraproteinemia, peripheral blood myeloma cells, and a marrow plasmacytosis with lytic bony lesion. The disease was refractory to standard chemotherapy, and she was treated with oral thalidomide. Within 1 week she became jaundiced and developed a marked transaminitis. This promptly resolved upon cessation of thalidomide alone. Thalidomide has recently enjoyed renewed interest as a treatment in many disorders, including plasma cell leukemia. To our knowledge, this is the first reported case of thalidomide‐associated hepatotoxicity. Although the mechanism of its actions on the liver are uncertain, it is possible that thalidomide acts as a direct hepatotoxin or as an immuno‐modulator, altering the activity of chronic viral hepatitis. We present this case to increase awareness of a new potential side effect of thalidomide as its clinical indications expand. Am. J. Hematol. 66:300–302, 2001. © 2001 Wiley‐Liss, Inc.
PATIENT CHARACTERISTICS AND OPERATIVE RISK WITH STAND-ALONE TRANSMYOCARDIAL REVASCULARIZATION
Authors: Keith B. Allen, Massoud A. Alzeerah, Geoffrey A. Answini, James E. Lowe, Averel B. Snyder, Pierre R. Tibi, Michael J. Mack, Timothy D. Henry
Journal: Journal of the American College of Cardiology (2011)
Savings from Canadian Internet Pharmacies Are Limited
Authors: Mark J. Eisenberg, Rafael Firszt, Bradley Quon
Journal: Annals of Internal Medicine (2006)

Letters7 February 2006Savings from Canadian Internet Pharmacies Are LimitedMark J. Eisenberg, MD, MPH, Rafael Firszt, MD, MBA, and Bradley Quon, MD, MBAMark J. Eisenberg, MD, MPHFrom Jewish General Hospital, McGill University, Montréal, Québec, H3T 1E2 Canada.Search for more papers by this author, Rafael Firszt, MD, MBAFrom Jewish General Hospital, McGill University, Montréal, Québec, H3T 1E2 Canada.Search for more papers by this author, and Bradley Quon, MD, MBAFrom Jewish General Hospital, McGill University, Montréal, Québec, H3T 1E2 Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-3-200602070-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Rothberg that Americans should not have to look north of the border to access more affordable medications. The underlying premise of our article was not to promote the purchase of Canadian pharmaceuticals but to quantify and highlight the differences in brand-name medication prices between the 2 countries. The average savings of 24% per unit that we cited should serve as a benchmark for Congress to target in lowering brand-name medication prices domestically for all Americans. Canadian-style strategies to lower medication prices, including price control through the Patented Medicines Price Review Board and the use ...Reference1. Pharmacy Benefits Management Strategic Healthcare Group. Drug and pharmaceutical prices. Accessed at www.pbm.va.gov/PBM/prices.htm on 17 November 2005. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Jewish General Hospital, McGill University, Montréal, Québec, H3T 1E2 Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Comparison of Brand-Name Drug Prices between Canadian-Based Internet Pharmacies and Major U.S. Drug Chain Pharmacies Bradley S. Quon , Rafael Firszt , and Mark J. Eisenberg Savings from Canadian Internet Pharmacies Are Limited Michael Rothberg Metrics 7 February 2006Volume 144, Issue 3Page: 224-225KeywordsConflicts of interestDrug pricesDrug regulationDrugsInternet ePublished: 7 February 2006 Issue Published: 7 February 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of electromagnetic fields on photophasic circulating melatonin levels in American kestrels.
Authors: K J Fernie, D M Bird, D Petitclerc
Journal: Environmental Health Perspectives (1999)

Birds reproduce within electromagnetic fields (EMFs) from transmission lines. Melatonin influences physiologic and behavioral processes that are critical to survival, and melatonin has been equivocally suppressed by EMFs in mammalian species. We examined whether EMFs affect photophasic plasma melatonin in reproducing adult and fledgling American kestrels (Falco sparverius), and whether melatonin was correlated with body mass to explain previously reported results. Captive kestrel pairs were bred under control or EMF conditions for one (short-term) or two (long-term) breeding seasons. EMF exposure had an overall effect on plasma melatonin in male kestrels, with plasma levels suppressed at 42 days and elevated at 70 days of EMF exposure. The similarity in melatonin levels between EMF males at 42 days and controls at 70 days suggests a seasonal phase-shift of the melatonin profile caused by EMF exposure. Melatonin was also suppressed in long-term fledglings, but not in short-term fledglings or adult females. Melatonin levels in adult males were higher than in adult females, possibly explaining the sexually dimorphic response to EMFs. Melatonin and body mass were not associated in American kestrels. It is likely that the results are relevant to wild raptors nesting within EMFs.
Cockcroft’s Formula Underestimates Glomerular Filtration Rate in Diabetic Subjects Treated by Lipid-Lowering Drugs
Authors: Caroline Perlemoine, Vincent Rigalleau, Laurence Baillet, Nicole Barthe, Marie-Christine Delmas-Beauvieux, Catherine Lasseur, Henri Gin
Journal: Diabetes Care (2002)

Comment -I interpret these results to support the recommendation of both the American Kidney Foundation and the American Diabetes Association that ACR can be used instead of a timed collection.Timed collections, 24 h or otherwise, are very inconvenient and often not collected accurately.Since albumin excretion is highly variable from day to day (up to 25%), a repeat ACR to fulfill the criterion of two of three positive values within a 3-to 6-month period as recommended for the diagnosis of microalbuminuria would very likely have reduced the false-positive rate of 6%.Mogensen CE: Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.
Putting the cart before the horse: testing to improve learning
Authors: Kevin W Eva
Journal: BMJ (2007)

One source of tension and debate among educators is the role that tests should play in education.On the one hand, some argue that there is a clear need for reliable and valid assessment.Others, however, worry about negative consequences of tests, such as "cramming."Although the cost:benefit ratio is highly dependent on the context in which testing is used, recent literature is burgeoning with suggestions that there may be pedagogical benefits to testing that have been underappreciated and understudied.
B7-CD28 costimulation unveils the hierarchy of tumor epitopes recognized by major histocompatibility complex class I-restricted CD8+ cytolytic T lymphocytes.
Authors: J V Johnston, A R Malacko, M T Mizuno, P McGowan, I Hellström, K E Hellström, H Marquardt, L Chen
Journal: The Journal of Experimental Medicine (1996)

Immunization of mice with tumors genetically engineered to express the B7 costimulatory molecules amplifies the antitumor immune response mediated by CD8+ cytolytic T lymphocytes (CTL). In this report, we examined the effect of B7-CD28 costimulation on the hierarchy of tumor epitopes. Using a combination of affinity chromatography/reversed-phase high performance liquid chromatography and CTL cloning, we show that major histocompatibility complex (MHC) class I molecules from EL4 lymphoma cells can present at least six distinct CTL epitopes presented by MHC class I molecules. Nevertheless, mice immunized with wild-type B7-negative EL4 cells develop CTL only to one immunodominant epitope. In contrast, immunization with B7-transduced EL4 cells led to not only the amplification of the CTL response to this immunodominant epitope, but also to the recognition of five otherwise silent subdominant epitopes. The adoptive transfer of a CTL clone against such a subdominant epitope cured mice bearing EL4 lymphoma growing as an ascites tumor. The fact that CTL response can be spread to normally silent epitopes as a result of B7-CD28 costimulation suggests a novel approach to manipulate the hierarchy of CTL epitopes and offers an opportunity to explore novel targets for T cell-mediated cancer therapy.
Viruria in dogs after injection of coxsackie B-1 virus into a renal artery.
Authors: I Schultz, C L Flanagan
Journal: Journal of Clinical Investigation (1965)

from blood to the urine after injection into a renal artery. Similar findings were noted after injection of virus into the aorta or into a peripheral vein. Moreover, with the stop-flow technique (6), localization of the point of initial viruria was possible. The site appears to be in a distal portion of the nephron, perhaps in the distal tubule.
Sodium bicarbonate and hyperventilation in treating an infant with severe overdose of tricyclic antidepressant.
Authors: D Hodes
Journal: BMJ (1984)

La malade (11 mois) a absorbe environ 13 comprimes de 75 mg de dothiepine (100 mg/kg). Coma avec convulsions et arythmie. Apres traitement des convulsions et lavage d'estomac, une bradycardie a 50/mn s'installe. Le traitement par bicarbonate i.v. et hyperventilation etablit une alcalose qui se montre efficace. Extubation au bout de 48 h
Acute Hemorrhage and Necrosis of the Intestines Associated with Digitalization
Authors: PETER C. GAZES, CHARLES R. HOLMES, VINCE MOSELEY, H. RAWLING PRATT-THOMAS
Journal: Circulation (1961)

Eleven cases with acute hemorrhage and necrosis of the bowel are described. In all cases there was high dosage of digitalis and definite toxicity in seven. Digitalis was considered as the main associated factor, especially since there was no mesenteric arterial involvement and, in four cases, there was no congestive failure at autopsy. Hepatic vein or sinusoidal sphincter constriction with resulting portal splanchnic venous congestion was considered as possible mechanisms by which digitalization produced this syndrome.
Book Review Rome II: The Functional Gastrointestinal Disorders Second edition. Edited by Douglas A. Drossman, with Enrico Corazziari, Nicholas H. Talley, W. Grant Thompson, and William E. Whitehead. 764 pp., illustrated. McLean, Va., Degnon, 2000. $99.50. 0-96568-371-0
Authors: Lawrence S. Friedman
Journal: New England Journal of Medicine (2001)
A pharmacogenetic effect of factor XIII valine 34 leucine polymorphism on fibrinolytic therapy for acute myocardial infarction
Authors: Francisco Marín, Rocío González-Conejero, Kaeng W. Lee, Javier Corral, Vanessa Roldán, Francisca López, Francisco Sogorb, Juan Caturla, Gregory Y.H. Lip, Vicente Vicente
Journal: Journal of the American College of Cardiology (2004)
William Knott Pallister
Authors: G Westbury, D J Pearce
Journal: BMJ (2008)

William Knott Pallister (“Bill”) was born in Sunderland in 1926, and at the age of 10 moved to Newport, Monmouthshire, where he attended Newport High School, excelling academically and in sport. He won an entrance scholarship to Westminster Medical School in 1944, where he qualified in 1949. He represented the medical school in rugby and cricket and …
Women with heart attacks have characteristic symptoms, says new study
Authors: F. Charatan
Journal: BMJ (2003)

Unusual fatigue, sleep disturbance, and shortness of breath are common symptoms in women who later have a heart attack, says a study published in Circulation, a journal of the American Heart Association, yet less than a third report chest discomfort before the attack.

The study surveyed 515 women aged 29 to 97, with an average age of 66, who had been discharged four to six months earlier from five hospitals in Arkansas, North Carolina, and Ohio, after having had a heart attack.

The women were surveyed for prodromal and acute symptoms. The researchers defined prodromal symptoms as being new or changing in intensity or frequency before the heart attack, being intermittent before the heart …
Quantification of the weakness and fatigue in thoracic outlet syndrome with isokinetic measurements
Authors: L Özçakar, F İnanıcı, B Kaymak, G Abalı, A Çetin, Z Hasçelik
Journal: British Journal of Sports Medicine (2005)

Patients with thoracic outlet syndrome (TOS) complain of many subjective symptoms that are difficult to measure and quantify. In this study we have tried to assess the weakness (muscle strength) and fatigue (endurance) of these patients with an objective measurement method, isokinetic muscle testing.Twenty three TOS patients and 15 age matched healthy controls were enrolled in the study. Detailed histories of the patients were taken and the patients underwent complete physical examinations. Cervical radiographies, Doppler ultrasonography, electromyography, and isokinetic measurements were carried out. The isokinetic measurements were carried using the Biodex System 3 dynamometer during concentric shoulder flexions and extensions at velocities of 60 degrees /s, 180 degrees /s, and 240 degrees /s.Although the muscle strengths of both groups seemed to be similar, the fatigue ratios of TOS patients at 60 degrees /s and 180 degrees /s were found to be higher compared with those of healthy controls (p = 0.029, p = 0.007).TOS patients were found to have muscular performance similar to controls, but their upper extremities developed fatigue more easily than those of healthy individuals.
Healing Skills for Medical Practice
Authors: Larry R. Churchill, David Schenck
Journal: Annals of Internal Medicine (2008)

It is well recognized that physicians' relationships with their patients can have healing effects, but the skills in this area of medical practice are understudied. This article reports on research designed to identify a core set of healing skills. The authors interviewed 50 practitioners, who were identified by their peers as healers, representing both allopathic and complementary medicine and alternative medicine. Interviews were tape-recorded, transcribed, made anonymous, and analyzed independently, and differences were reconciled by discussion. Eight skills emerged as pivotal from the transcripts of these interviews: do the little things; take time; be open and listen; find something to like, to love; remove barriers; let the patient explain; share authority; and be committed. Mastery of these skills would provide enduring improvements in patient care and reaffirm medicine's calling as a healing profession.
Danger in Many Forms Lurks Around US Military Medical Bases in Bosnia
Authors: Phil Gunby
Journal: JAMA (1997)

RENEWED fighting among warring factions in the former Yugoslavia is a continuing threat to US military medical and other personnel supporting the North Atlantic Treaty Organization (NATO) peace-enforcement effort.  But there are other dangers as well. NATO troops patrol in convoys of at least 4 vehicles, supported by heavy weapons, and await efforts of an estimated 170 000 refugees to return to the 4-km demilitarized area between Bosnian Serbs, Croats, and Muslims. Military medical people from the United States and other NATO member countries are standing by, taking care of the various illnesses and other problems that arise in their soldier populations and hoping that they will not be called on to treat battle casualties.  In the meantime, there are concerns about land mines—2 local women accidentally triggered a mine near a US base in Bosnia-Herzegovina recently, resulting in the death of one and serious injury of the other—rabies and
Reduction, supervenience, and physical emergence
Authors: John Collier
Journal: Behavioral and Brain Sciences (2004)

After distinguishing reductive explanability in principle from ontological deflation, I give a case of an obviously physical property that is reductively inexplicable in principle. I argue that biological systems often have this character, and that, if we make certain assumptions about the cohesion and dynamics of the mind and its physical substrate, then it is emergent according to Broad's criteria.
TEST-yolk media and sperm quality
Authors: R. Jeyendran
Journal: Human Reproduction Update (1995)

Journal Article TEST-yolk media and sperm quality Get access R.S. Jeyendran, R.S. Jeyendran 1 1Andrology Laboratory Services, Inc.680 North Lake Shore Drive, Suite 1025, Chicago, IL 60611;2Department of Obstetrics and Gynecology, Northwestern University Medical SchoolChicago, IL, USA3Department of Physical Medicine and Rehabilitation, Northwestern University Medical SchoolChicago 1 To whom correspondence should be addressed at Andrology Laboratory Services Search for other works by this author on: Oxford Academic PubMed Google Scholar V.K. Gunawardana, V.K. Gunawardana 1 1Andrology Laboratory Services, Inc.680 North Lake Shore Drive, Suite 1025, Chicago, IL 60611; 1 To whom correspondence should be addressed at Andrology Laboratory Services Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Barisic, D. Barisic 1Andrology Laboratory Services, Inc.680 North Lake Shore Drive, Suite 1025, Chicago, IL 60611; Search for other works by this author on: Oxford Academic PubMed Google Scholar A.C. Wentz A.C. Wentz 2Department of Obstetrics and Gynecology, Northwestern University Medical SchoolChicago, IL, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction Update, Volume 1, Issue 1, 1 January 1995, Pages 73–79, https://doi.org/10.1093/humupd/1.1.73 Published: 01 January 1995 Article history Received: 31 August 1994 Accepted: 02 September 1994 Published: 01 January 1995
Late Recognition of Bronchogenic Carcinoma in the Thoracic Inlet
Authors: Richard K. Hughes
Journal: JAMA (1965)

Bronchogenic carcinoma in the thoracic inlet prior to obvious signs and symptoms of Pancoast's syndrome is difficult to recognize, and should be considered more frequently as a cause of pain in the shoulder and arm. This study of four cases illustrates this fact. Abnormal physical findings are late manifestations of the lesion. Interpretation of conventional thoracic roentgenograms may be misleading unless apical regions are carefully compared. The clinician should beware of roentgenologic findings interpreted as thickened apical pleura. Recent reports indicate possible cures of this tumor following a combination of radiation therapy and resection. In view of such reports, early recognition of bronchogenic carcinoma in the thoracic inlet is of greater importance than ever.
Pseudohyperphosphataemia in multiple myeloma.
Authors: E. V. McCloskey, J. Galloway, M. A. Morgan, J. A. Kanis
Journal: BMJ (1989)

intravenous nutrition solutions have been well tolerated when the osmolality is less than 983 mmol/l but the daily risk of extravasation is 0-54 for "butterfly" needles and ofphlebitis 0 25 for short plastic catheters.'The daily risk of phlebitis with our fine silicone catheters was 0-016, with a median period of function of nine days.One patient with pancreatic abscess received 60 days of complete intravenous nutrition through a single catheter.There were no bacteraemic episodes related to the catheter, while the expected rate with central intravenous nutrition is 4%.Intravenous nutrition solutions providing 70% of non-protein calories as lipid are efficacious,,' but their use has been limited because they are unsupported by an adequate delivery system.Their use with a fine silicone catheter may avoid the need for central vein cannulation in 89% of inpatients requiring intravenous nutrition.1 Muller JM.Parenteral approaches in total parenteral nutrition tjherapy.Peripheral venous catheter versus central venous catheter.
Assessment of Caspase Activities in Intact Apoptotic Thymocytes Using Cell-Permeable Fluorogenic Caspase Substrates
Authors: Akira Komoriya, Beverly Z. Packard, Martin J. Brown, Ming-Lei Wu, Pierre A. Henkart
Journal: The Journal of Experimental Medicine (2000)

To detect caspase activities in intact apoptotic cells at the single cell level, cell-permeable fluorogenic caspase substrates were synthesized incorporating the optimal peptide recognition motifs for caspases 1, 3/7, 6, 8, and 9. Caspase activities were then assessed at various times after in vitro treatment of mouse thymocytes with dexamethasone or anti-Fas antibody. Dexamethasone induced the following order of appearance of caspase activities as judged by flow cytometry: LEHDase, WEHDase, VEIDase, IETDase, and DEVDase. Since the relative order of caspases 3 (DEVDase) and 6 (VEIDase) in the cascade has been controversial, this caspase activation order was reexamined using confocal microscopy. The VEIDase activity appeared before DEVDase in every apoptotic cell treated with dexamethasone. In contrast, anti-Fas stimulation altered this sequence: IETDase was the first measurable caspase activity and DEVDase preceded VEIDase. In an attempt to determine the intracellular target of the potent antiapoptotic agent carbobenzoxy-valyl-alanyl-aspartyl(beta-methyl ester)-fluoromethyl ketone (Z-VAD[OMe]-FMK), we examined its ability to inhibit previously activated intracellular caspases. However, no significant reductions of these activities were observed. These fluorogenic caspase substrates allow direct observation of the caspase cascade in intact apoptotic cells, showing that the order of downstream caspase activation is dependent on the apoptotic stimulus.