tbuckley/cabot-search huggingface dataset:
Application of the “covered-stent-in-uncovered-stent” technique for easy and safe removal of embedded biliary uncovered SEMS with tissue ingrowth
Authors: F. Arias Dachary, C. Chioccioli, P. Deprez
Journal: Endoscopy (2010)

Removal of embedded biliary uncovered self-expandable metal stents (uSEMS) is regarded as difficult or even impossible when the duration of indwell exceeds a couple of weeks, because of the ingrowth of tissue [1] [2] [3]. The presence of diffuse and severe ingrowth is the main feature limiting SEMS removal [1]. In the esophagus, placement of a self-expanding plastic stent (SEPS) inside the SEMS has been shown to induce pressure necrosis of this tissue hyperplasia, allowing subsequent removal of the stent [4]. We applied this technique in a 58-year-old patient with a history of alcohol abuse, obstructive jaundice, and suspected malignancy, in whom an uSEMS 10 mm wide and 6 cm long (Wallflex; Boston Scientific, Natick, Massachusetts, USA) had been mistakenly inserted more than 1 year before. The patient had experienced recurrent cholangitis due to stent obstruction caused by tissue ingrowth. Stent removal was therefore considered, but was unsuccessful using conventional maneuvers. A covered SEMS (Wallflex) was then placed inside the uSEMS ([Figs. 1], [2]).
Portfolio for Health — Policy on Heart Transplants — Labour Party's Health Plans
Authors: John Lister
Journal: New England Journal of Medicine (1973)

IN the early years of the National Health Service the immediate task of the Ministry of Health, later incorporated in the Department of Health and Social Security, was to ensure that adequate standards of medical and surgical care, either in the home or in the hospital, were made available to the population of the whole country. The majority of the hospitals inherited by the Service were old, and much ingenuity was required to upgrade them with the limited finance available. More recently, there has been considerable activity in new hospital building; gradually, a pattern is emerging, with district general hospitals . . .
Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST
Authors: Agnieszka Wozniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray-Coquard, Isabelle Hostein, Hans-Ulrich Schildhaus, Axel Le Cesne, Elzbieta Bylina, Janusz Limon, Jean-Yves Blay, Janusz A. Siedlecki, Eva Wardelmann, Raf Sciot, Jean-Michel Coindre, Maria Debiec-Rychter
Journal: Clinical Cancer Research (2014)

Abstract Purpose: Although the mutational status in gastrointestinal stromal tumors (GIST) can predict the response to treatment with tyrosine kinase inhibitors, the role of tumor genotype as a prognostic factor remains controversial. The ConticaGIST study sought to determine the pathologic and molecular factors associated with disease-free survival (DFS) in patients with operable, imatinib-naive GIST. Experimental Design: Clinicopathologic and molecular data from 1,056 patients with localized GIST who underwent surgery with curative intention (R0/R1) and were registered in the European ConticaGIST database were prospectively obtained and reviewed. Risk of tumor recurrence was stratified using the modified NIH criteria. The median follow-up was 52 months. Results: On testing for potential prognostic parameters, the following were associated with inferior DFS on multivariable Cox model analysis: primary nongastric site, size &amp;gt;10 cm, mitotic index &amp;gt;10 mitoses per 50 high power field, and the KIT exon 9 duplication [hazard ratio (HR), 1.47; 95% confidence interval (CI), 0.9–2.5; P = 0.037] and KIT exon 11 deletions involving codons 557 and/or 558 [KITdel-inc557/558; HR, 1.45; 95% CI, 1.0–2.2; P = 0.004]. Conversely, PDGFRA exon 18 mutations were indicators of better prognosis [HR, 0.23; 95% CI, 0.1–0.6; P = 0.002]. KITdel-inc557/558 were an adverse indicator only in GIST localized in the stomach (P &amp;lt; 0.001) but not in tumors with nongastric origin. In gastric GIST, all other mutations presented remarkably superior 5-year DFS. Conclusions: In conclusion, tumor genotype is an independent molecular prognostic variable associated with gastric GIST and should be used for optimizing tailored adjuvant imatinib treatment. Clin Cancer Res; 20(23); 6105–16. ©2014 AACR.
Quantitative Analysis of Intraventricular Dyssynchrony Using Wall Thickness by Multidetector Computed Tomography
Authors: Quynh A. Truong, Jagmeet P. Singh, Christopher P. Cannon, Ammar Sarwar, Khurram Nasir, Angelo Auricchio, Francesco F. Faletra, Antonio Sorgente, Cristina Conca, Tiziano Moccetti, Mark Handschumacher, Thomas J. Brady, Udo Hoffmann
Journal: JACC. Cardiovascular imaging (2008)
OPERATION FOR CANCER OF THE MOUTH.
Authors: W. W. GRANT
Journal: JAMA (1905)

The advantages claimed for the new operation which I have recommended<sup>1</sup>for carcinoma of the lip are: a better, more useful mouth, and, with less tension, a fuller and more natural lip and expression. There is also the distinct esthetic advantage that the lines of incision are less conspicuous, and in men, the usual victims of carcinoma, are soon covered entirely by beard. Plastic surgery means the free use of the knife in liberal incisions, and infinite patience and attention to details. In some respects this is more important in the surgery of the face than of any other part of the body. I know of no department of surgery which taxes more severely the skill, nice sense of proportion, harmony and delicate technic of the surgeon. In the unusually bad cases I report, the operation is tedious, bloody, of rather extensive proportions, and formidable in appearance during its progress;
Building Bridges Between Medical Care and Public Health
Authors: Nicole Lurie
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Redefining memory consolidation
Authors: Mercedes Atienza, Jose L. Cantero
Journal: Behavioral and Brain Sciences (2005)

Based on brain state-dependent behavioral changes, consolidation of sensorimotor memories has been posited to evolve in two different functional stages. Only the second of these stages requires sleep and leads to performance benefits. Recent results, however, suggest that sleep is not always crucial for the expression of delayed behavioral gains but might be critical for enhancing automaticity in the absence of attention, another expression of memory consolidation.
Presence of bone-marrow- and neural-crest-derived cells in intimal hyperplasia at the time of clinical in-stent restenosis
Authors: D Skowasch
Journal: Cardiovascular Research (2003)

Objective: Intralesional data of coronary target lesions following stent implantation are infrequent. In addition, there is ongoing controversy on the origin of neointimal cells. In this respect, several lines of evidence revealed bone-marrow-derived endothelial progenitor and dendritic cells (DCs) as well as neural-crest-derived cells (NCCs) to contribute to atherosclerosis. Therefore, the objective of the present study was to assess cellularity, cell type and origin of neointimal cells in in-stent restenosis (ISR). Methods: Atherectomy specimens from 17 patients with coronary in-stent restenosis (n = 10; time post-stenting 5±3 months) and with peripheral in-stent restenosis (n = 7; 7±3 months) versus those from 10 patients with primary lesions were immunohistochemically examined for the presence of the determinants CD34, AC133, S100, glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), nerve growth factor receptor (NGFR) and α-smooth muscle actin followed by computer-assisted morphometry. Results: In-stent restenosis probes consistently demonstrated homogeneous hypercellularity (942±318 cells/mm2) compared to de novo lesions (347±120 cells/mm2, P<0.001). α-smooth muscle actin positive cells occupied 67% of intimal cells in in-stent restenosis. As a key finding, expression of endothelial progenitor cells (CD34: 7.1±2.5% positive/total cells vs. 0.6±0.7%, P<0.001; AC133: 7.0±3.4% vs. 1.0±0.7%, P<0.001), dendritic cells (S100: 9.8±5.6% vs. 1.4±1.1%, P<0.001) and neural-crest-derived cells (GFAP: 7.9±2.4% vs. 3.1±1.0%; NSE: 4.4±2.6% vs. 1.3±1.6%; NGFR: 4.2±2.5% vs. 1.1±0.7%; each P<0.001) was significantly increased in in-stent restenosis compared to primary lesions. Conclusions: Bone-marrow- and neural-crest-derived cells, the most dendritic cells, are consistently present in in-stent restenosis, whereas α-smooth muscle actin positive cells constitute the largest intimal cell pool. Our data suggest the recruitment of primarily extravascular cells within neointima formation in human in-stent restenosis.
Splenic irradiation in treating warm autoimmune haemolytic anaemia.
Authors: H Markus, J C Forfar
Journal: BMJ (1986)

An elderly man with severe congestive heart failure was noted to have a haemoglobin concentration of 87 g/l and a reticulocyte count of 13%. Direct Coombs test yielded a positive result and the serum contained a moderate amount of warm antibody (IgG class). Steroids were given, but to no avail, and the patient9s condition precluded splenectomy. A course of splenic irradiation was therefore tried (midline dose 2000 cGy (rads)), and 60 days later the blood film showed similar appearances to those in patients treated successfully by splenectomy. Haemoglobin concentration subsequently rose to normal. Splenic irradiation may offer a simple treatment for resistant warm autoimmune haemolytic anaemia when splenectomy is contraindicated.
Sport and exercise medicine for pharmacists
Authors: C Milne
Journal: British Journal of Sports Medicine (2006)

Edited by Steven B Kayne. Published by Pharmaceutical Press, 2006, pp 376. £29.95, softcover. ISBN 0853696004

I offered to review this book as, firstly, I am interested in the topic and, secondly, I am married to a pharmacist (she is the health professional I see most often). Her views are included along with my own.

What should pharmacists be taught about sports medicine in a 350 page book? Pretty well the range of topics covered by the chapters in this monograph, with some variation in content as I will suggest below.

The opening chapters describe the physiology of exercise, sports nutrition, and the role of physical activity in the community. Each of these is an excellent synopsis of the current state of knowledge in each of these areas, with …
Ultrasonography and perinatal mortality rates.
Authors: D J Cahill
Journal: BMJ (1991)

with her strong need to express love-two very different things.Among all deaths the sudden traumatic death of a young person tends to have the greatest impact on the bereaved, who therefore need particularly careful handling.Bereaved people should always be offered the chance to see the body, and generally this should be encouraged.It is an important part of accepting the reality and often helps to dispel the imagined disfigurement.Fact is generally preferable to fantasy, and what right have we to protect bereaved people?The deceased is their relative, and their feelings will tell them what they need to do.We are perhaps just protecting ourselves and hindering them in the process.Seeing the body is also a chance for the people to inspect, touch, hold, kiss, or say goodbye to their loved one.Staff should give permission for these free expressions, as well as allow the chance for bereaved people to be left alone with the body.2Some may need several visits.Sheila Awooner-Renner was unnecessarily (and cruelly) kept waiting, and when she eventually got to her son she felt inhibited and was watched.There was no need to wait for the coroner's officer.How are we to avoid this well meaning but inappropriate handling of distressed relatives?The hospice movement has led the way, but the acute sector needs a system for coping 24 hours a day.Accident and emergency departments are increasingly recognising the needs of bereaved people, regarding them as unofficial patients (often led by nurses).As well as the senior accident and emergency staff hospital chaplains, social workers,
Cost effectiveness analysis in health care: contraindications
Authors: C. Donaldson
Journal: BMJ (2002)

In economic evaluation of healthcare interventions, the dominant practice is to calculate an incremental cost effectiveness ratio, usually based on the comparison of a new intervention against current practice. Canadian and UK health economists question the economic foundations of such an approach Who could resist implementing the results of a study showing that using alteplase (tPA; tissue plasminogen activator) rather than streptokinase in treatment of acute myocardial infarction costs $32 678 (£21 340; €33 330) per life year gained, which the authors declare to be "cost effective by customary criteria"?1 Despite similar claims from several such studies, the impact of economic evaluation on setting of priorities remains unclear.2–4 Among the reasons given for this are that opportunities for reducing costs while maintaining quality still arise, and that cost effectiveness analyses do not take all factors into account.3 Achieving the same result more cheaply—a success for economics—represents a classic cost effectiveness approach. The possibility that not all factors have been considered suggests that other approaches may make economic evaluation more relevant. We contend that, beyond the classic approach, many studies labelled as cost effectiveness analyses of health care are not really that at all. At best, this mislabelling is confusing: at worst, conclusions drawn by the studies' authors could be harmful to patients' health. Thus, there are contraindications to the use of cost effectiveness analysis in health care, and an alternative economic approach is required. In this paper we revisit the basic economic principles. Then we make the case that lack of adherence to such principles, through current practice of reducing everything to incremental cost effectiveness ratios, leads to contraindications. #### Summary points
Gastritis, aspirin, and alcohol.
Authors: G K Hodgkin, J Whewell
Journal: BMJ (1967)

of these cases was strongly positive on the bone marrow, though only very weakly posi- tive on the peripheral blood.The anti-D antibody titre was 1/1,024.Exaimination of this infant's blood showed that virtually only Rh-negative cells (that is, like those given by transfusion) were present.This observation supports the hypothesis that the late anaemia seen in verysevere Rh disease is due to the persistence of antibodies in the blood.This phenomenon has become apparently more common recently, since, because intrauterine transfusion is now per- formed, these infants do not require large exchange transfusion at birth, and also there is an increasing survival of severe cases.-We are, etc.,
Idiopathic Pulmonary Haemosiderosis in an Adult
Authors: J. R. Edge, A. P. B. Waind
Journal: Thorax (1959)

Sputum contained many macrophages heavily laden with haemosiderin, and many red cells, but no eosinophils.On culture, it gave a mixed growth of pneumococci and coliform bacilli.An electrocardiogram was normal.The urine on, routine testing showed no abnormality.Haemoglobin concentration was 80%.Erythrocytes numbered 4,320,000 per c.mm., of which reticulocytes were 1 % ; platelets numbered 250,000, and leucocytes 9,300 per c.mm., with a normal differential on August 20,
Is Worrying Bad for Your Heart?
Authors: Laura D. Kubzansky, Ichiro Kawachi, Avron Spiro, Scott T. Weiss, Pantel S. Vokonas, David Sparrow
Journal: Circulation (1997)

Worry is an important component of anxiety, which recent work suggests is related to increased incidence of coronary heart disease (CHD). Chronic worry has also been associated with decreased heart rate variability. We hypothesized that high levels of worry may increase CHD risk.We examined prospectively the relationship of worry with CHD incidence in the Normative Aging Study, an ongoing cohort of older men. In 1975, 1759 men free of diagnosed CHD completed a Worries Scale, indicating the extent to which they worried about each of five worry domains: social conditions, health, financial, self-definition, and aging. During 20 years of follow-up, 323 cases of incident CHD occurred: 113 cases of nonfatal myocardial infarction (MI); 86 cases of fatal CHD; and 124 cases of angina pectoris. Worry about social conditions was the domain most strongly associated with incident CHD. Compared with men reporting the lowest levels of social conditions worry, men reporting the highest levels had multivariate adjusted relative risks of 2.41 (95% CI, 1.40 to 4.13) for nonfatal MI and 1.48 (95% CI, 0.99 to 2.20) for total CHD (nonfatal MI and fatal CHD). A dose-response relation was found between level of worry and both nonfatal MI (P for trend, .002) and total CHD (P for trend, .04).These results suggest that high levels of worry in specific domains may increase the risk of CHD in older men.
A Functional Polymorphism in the RANTES Gene Promoter Is Associated with the Development of Late-Onset Asthma
Authors: Nobuyuki Hizawa, Etsuro Yamaguchi, Satoshi Konno, Yoko Tanino, Eisei Jinushi, Masaharu Nishimura
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

The CC chemokine regulated upon activation, normal T-cell expressed and secreted (RANTES) attracts eosinophils, basophils, and T cells during inflammation and immune response, indicating a possible role for this chemokine in asthma. Both the -403A and -28G alleles of the RANTES promoter region exhibit significantly enhanced promoter activity in reporter constructs in vitro. We therefore investigated the genetic influence of these alleles on the development of asthma using case-control analysis in a Japanese population (298 patients with asthma and 311 control subjects). Given the evidence for heterogeneity of asthma according to age at onset, we divided patients with asthma into three subgroups: 117 late-onset patients with asthma (onset at more than 40 years of age), 83 middle-onset patients with asthma (onset at 20 to 40 years of age), and 98 early-onset patients with asthma (onset at less than 20 years of age). The -28G allele was significantly associated with late-onset asthma (odds ratio = 2.033; 95% confidence interval, 1.379-2.998; corrected p < 0.0025) but was not associated with the other two asthma subgroups. The -403A allele was not associated with any of the asthma subgroups. Further evidence of the importance of the -28G allele was a significant increase in the production of RANTES in vitro in individuals who carried this allele. Our findings suggest that, among Japanese, the -28G allele of the RANTES promoter region confers susceptibility to late-onset asthma.
Effect of Early Industrialism on the Health of the Community
Authors: M. C. Buer
Journal: BMJ (1927)

On this McCollum2 wrote: " Osborne and Mendel observed calculi of calcium phosphate in the urinary tract in 91 [read 81) animals among 857 necropsies; 43 per cent. of these had not had a satisfactory supply of vitamin A. In McCollum and Simmonds's experience calculi have occurred so frequently in animals whose diets contained an abundance of this factor, buit were faulty in other respects, that it would seem to be the results of general debility rather than lowered vitality brought about by specii1C cause."The contradiction in, the observations of the experi- menters led me to control the records of the rats of the laboratory of tlle Netherlands Instituto of Nutrition.I have examined 886 rats, piebalds and albinos, of which 405 were males and 481 females.Among them are 241 rats (see Other Lesions.NubrCases of ___ Diet.Nubrca1 cu- of Rats.
Pneumococcal Meningitis in the Adult: Clinical, Prognostic, and Therapeutic Findings in Forty-three Patients.
Authors: J. C. Kirby
Journal: Annals of Internal Medicine (1961)

Abstracts1 May 1961Pneumococcal Meningitis in the Adult: Clinical, Prognostic, and Therapeutic Findings in Forty-three Patients.Authors: J. C. Kirby, M.D., R. A. Olsson, M.D., and M. J. Romansky, M.D., F.A.C.P.Author, Article, & Disclosure InformationPublication: Annals of Internal MedicineVolume 54, Number 5https://doi.org/10.7326/0003-4819-54-5-1056_1 Get AccessSubmit a CommentContributors must reveal any conflict of interest. Comments are moderated. Please see our information for authorsregarding comments on an Annals publication.Name (if multiple authors, separate names by comma)Name field is requiredComment TitleTitle field is requiredAffiliation & Institution (max characters: 200)Affiliations field is requiredCommentComment field is requiredPlease disclose any conflicts of interest or leave the box unchecked if you have noneDisclosure of Any Conflicts of InterestCancelSubmit
Treatment of Patients with Metastatic Pancreatic Cancer: the Tata Memorial Centre (TMC) Experience
Authors: Sirohi Bhawna, Dawood Shaheenah, Ostwal Vikas, Bal Munita, Shetty Nitin, Pandey Avinash, Engineer Reena, Shrikhande Shailesh
Journal: Annals of Oncology (2014)
Space station, shuttle offer new medical possibilities
Authors: Phil Gunby
Journal: JAMA (1984)

While space adaptation syndrome is being studied, two more "firsts"—one with implications for medicine—are scheduled in space next month. At the same time, planning is under way for yet another first. It's a permanent space station, announced earlier this year and expected to be in orbit about 400 km (250 miles) above the earth within ten years. In a matter of days, not years, however,<i>Discovery</i>, the newest of the space shuttle vehicles, is scheduled to make its first flight. That June 21 launch will be a first, and so is the plan for mission-long production of a so-far-undisclosed biologic material. Two companies are collaborating on this bioprocessing in space, using continuous flow electrophoresis. Continuous flow electrophoresis in space separates whatever product is desired from a flow of the sample or culture material through use of an electric field. In the weightlessness of space, a much more concentrated solution can