tbuckley/cabot-search huggingface dataset:
ACPA response against fibrinogen epitopes citrullinated in vivo in the synovial membrane in RA patients detected with an autoantibody microarray
Authors: E Ossipova, M Hansson, L Mathsson, L Klareskog, P-J Jakobsson, J Rönnelid
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Backgroundand objectives</h3> Citrullination is a post-translational modification of proteins catalysed by specific peptidylarginine deiminases, which modify arginine residues to citrulline. Citrullinated proteins are frequently detected in various inflammatory states including rheumatoid arthritis, and a lot of attention has been drawn to the presence of auto-antibodies targeting proteins containing citrulline. Using high resolution mass spectrometry (MS) the authors have first identified citrullinated peptides corresponding to amino acids 559–575 of fibrinogen α-chain and corresponding to amino acids 52–77 of the fibrinogen β-chain in synovial tissues from patient with rheumatoid arthritis (RA) (Hermansson <i>et al</i> Proteomics: Clinical Applications 2010). In this work the authors have also identified citrullinated peptide corresponding to amino acids 580–599 of fibrinogen α-chain but decided do not include it to publication due to possible deamidation of asparagine or glutamine, which leads to the same mass shift as deamidation of arginine. In this follow-up study The authors test sera from RA patients for anticitrullinated protein antibodies (ACPA) response against MS identified citrullinated fibrinogen peptides. <h3>Material and methods</h3> In this work a microarray assay based on Phadia´s ImmunoCAP ISAC system, where reactivity to more than 100 antigens can be analysed simultaneously using small volumes of sera, was employed. Four synthetised fibrinogen peptides (containing citrulline at the positions 573 (Fib 573), 591 (Fib 591) within the α-chain and at the positions 72 (Fib 72) and 74 (Fib 74) within the β-chain, respectively) were immobilised onto a chemically modified glass slide in an arrayed fashion. After binding of antigens to the glass surface diluted serum from 936 RA patients (404 cyclic citrullinated peptide (CCP) positive and 532 CCP negative) and 461 healthy controls from the Epidemiological Investigations in Rheumatoid Arthritis (EIRA) case control cohort were applied into reactions sites on the glass slides, followed by fluorescent-labeled anti-human IgG antibody and scanning in a laser scanner. Cutoff values were determined as the 98th percentile of the healthy control responses. <h3>Results</h3> The authors found that 31% (among them 87% are CCP positive) of patients were positive to Fib573 peptide. For the Fib2591 peptide, the corresponding figures were 10% (65%), for the Fib74 peptide 28% (68%) and for the Fib72 peptide 20% (68%). <h3>Conclusions</h3> Here the authors show extensive autoantibody reactivity against fibrinogen epitopes that are citrullinated in vivo in RA synovial membranes. A substantial part of the ACPA peptide reactivities were found among anti-CCP2 negative RA patients. The results suggest the use of these citrullinated fibrinogen peptides as biomarkers in RA.
Colonic Localization of lndium-111 Labeled Leukocytes in Active Behcet??s Disease
Authors: RAYMOND G. HARRE, GARY R. CONRAD, JAMES E. SEABOLD
Journal: Clinical Nuclear Medicine (1988)

A patient with known Behcet's disease demonstrated intense colonic localization of In-111 labeled leukocytes. Gastrointestinal involvement had not been previously manifested, but extensive colonic inflammation was documented by endoscopy. This case illustrates the utility of In-111 labeled leukocyte imaging for detecting active bowel disease in a debilitated patient with documented Behcet's vasculitis.
Standardized Deflections on ECGs
Authors: Jack R. Harnes
Journal: JAMA (1984)

<h3>To the Editor.—</h3> A properly performed ECG should include a standardization deflection. This ensures that 1 mV of current will result in a 1-cm deflection and that the excursions of waves in successive tracings may be accurately compared. When QRS excursions are large, half standardization (1 mV=0.5 cm) may be used. When the standardization deflection shows overshooting or, more commonly, slurring (ie, the initial upright and terminal upright deflections are not at right angles to the baseline), artifactual distortion of the ECG complexes may occur. As medical director of a life insurance company, I review ECGs taken by hospitals and physicians for clinical purposes and by examining physicians and paramedical examination facilities for insurance purposes. I reviewed 500 successive ECGs in life insurance applications for the presence and nature of standardization deflections. One entry was made for successive ECGs submitted by one source on one insurance application if the nature
Cardiopulmonary Resuscitation-Reply
Authors: Arno L. Zaritsky
Journal: JAMA (1993)

<h3>In Reply.</h3> —We know that endotracheal drug administration is inferior to intravenous administration and should only be used when personnel cannot obtain intravenous access. However, when endotracheal drug administration is the only possibility, should we inject the agents through the proximal port of the endotracheal tube or through a catheter threaded down the endotracheal tube? Administration through a catheter is more cumbersome and time-consuming. Does catheter administration produce better drug levels in the circulation? Researchers have not observed consistent results regarding which technique produces superior drug delivery. The study quoted by Dr Muñiz observed no differences in the serum lidocaine levels when lidocaine diluted in saline was administered at four different locations in the lungs: upper end of the endotracheal tube, proximal carina, right main stem bronchus, or right lower lobe bronchus.<sup>1</sup>This study was limited by the fact that these were well-perfused patients with normal cardiac outputs. Absorption
Phase I Trial of MS-275, a Histone Deacetylase Inhibitor, Administered Weekly in Refractory Solid Tumors and Lymphoid Malignancies
Authors: Shivaani Kummar, Martin Gutierrez, Erin R. Gardner, Erin Donovan, Kyunghwa Hwang, Eun Joo Chung, Min-Jung Lee, Kim Maynard, Mikhail Kalnitskiy, Alice Chen, Giovanni Melillo, Qin C. Ryan, Barbara Conley, William D. Figg, Jane B. Trepel, James Zwiebel, James H. Doroshow, Anthony J. Murgo
Journal: Clinical Cancer Research (2007)

MS-275 is a histone deacetylase inhibitor that has shown potent and unique anticancer activity in preclinical models. The aims of this phase I trial were to determine the dose-limiting toxicities and maximum tolerated dose of oral MS-275 in humans administered with food on a once weekly schedule and to study the pharmacokinetics of oral MS-275.Patients with refractory solid tumors and lymphoid malignancies were treated with oral MS-275 on a once weekly schedule for 4 weeks of a 6-week cycle. Samples for pharmacokinetic and pharmacodynamic analyses were collected during cycle 1. Protein acetylation in subpopulations of peripheral blood mononuclear cells was measured using a multivariable flow cytometry assay.A total of 22 patients were enrolled, and 19 were considered evaluable for toxicity. The maximum tolerated dose was 6 mg/m(2). No National Cancer Institute Common Toxicity Criteria grade 4 toxicities were observed. Dose-limiting grade 3 toxicities were reversible and consisted of hypophosphatemia, hyponatremia, and hypoalbuminemia. Non-dose-limiting grade 3 myelosuppression was also observed. The mean terminal half-life of MS-275 was 33.9 +/- 26.2 and the T(max) ranged from 0.5 to 24 h. Although there was considerable interpatient variability in pharmacokinetics, the area under the plasma concentration versus time curve increased linearly with dose.MS-275 is well tolerated at a dose of 6 mg/m(2) administered weekly with food for 4 weeks every 6 weeks. Drug exposure increases linearly with dose, and protein acetylation increased in all the subpopulations of peripheral blood mononuclear cells following MS-275 administration.
A role for sex chromosome complement in the female bias in autoimmune disease
Authors: Deborah L. Smith-Bouvier, Anagha A. Divekar, Manda Sasidhar, Sienmi Du, Seema K. Tiwari-Woodruff, Jennifer K. King, Arthur P. Arnold, Ram Raj Singh, Rhonda R. Voskuhl
Journal: The Journal of Experimental Medicine (2008)

Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.
Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer
Authors: I-Ting Teng, Ya-Ju Chang, Li-Sheng Wang, Hsin-Yi Lu, Li-Chen Wu, Chia-Min Yang, Chih-Chung Chiu, Chih-Hsueh Yang, Shih-Lan Hsu, Ja-an Annie Ho
Journal: Biomaterials (2013)
Imaging of Abdominal and Pelvic Anatomy
Authors: D NOLAN
Journal: Gut (1998)

Imaging of Abdominal and Pelvic Anatomy. Edited by Weill FS, Manco-Johnson ML. (Pp 384; illustrated; £99.00.) Edinburgh: Churchill Livingstone, 1997. ISBN 0-443-05238-7.

During the past 20 years the newer imaging techniques of ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI) have significantly advanced the diagnosis and management …
TWO DIFFERENT WAYS IN WHICH YELLOW FEVER MAY BE TRANSMITTED BY THE CULEX MOSQUITO—STEGOMYIA TAENIATA.
Authors: CHARLES J. FINLAY
Journal: JAMA (1901)

of its entire corps of medical inspectors.The emolu- ment is $50 per month and, to cover the ground pro- perly, a man must devote his entire -working morning to the service, i. e.. from 9 a. m. to 12 m.When the ap- propriation runs low four-fifths of the inspectors are dismissed and an emergency corps representing the three major divisions of the city is selected from the eligible list.These inspectors do not make daily visits but respond to special calls from a school principal when in his opinion local conditions demand attention.This method does not, of course, compare with the regular daily visits of qualified physicians but seems to be the best that can be done by the School Board when finan- cial stress is acute.That feature of the Boston system relating to the dis- covery of infectious disease in the schoolroom, in which event the medical inspector orders the child sent home, reports the case to the Board of Health and follows the case home to see that it is properly isolated there, shows a defect in the Chicago system.When recovery is re- ported, in the former city, by the family physician, the inspector determines whether all danger of spreading the infection has ceased.Another improvement might be adopted from the New York rules in this matter, viz., that provision re- quiring the principal or head teacher in charge to make weekly reports of the names and addresses of all ab- sentees and, if absent on account of illness, naming the disease if possible.In Chicago such list might be handed to the local truant officer who has the right to
Post-vagotomy Neuroma
Authors: E. N. MacDermott
Journal: BMJ (1966)

child to hospital if it seems possible that it has been deliberately injured, whether by parents or baby-minder or older sibling.The child is then in a " place of safety " and can be kept there, as the B.P.A. memorandum makes clear.But once it is there, the best interests of the baby and the rehabilitation of the parents are not contradictory aims: they are joint ones, and the apparatus for dealing with both is available.-Iam, etc.,
Endogenous Erythroid Colony Formation in Patients with Retinal Vein Occlusion
Authors: Emmanuel Héron, Christophe Marzac, Sylvie Feldman-Billard, Jean-François Girmens, Michel Paques, Richard Delarue, Jean-Charles Piette, Nicole Casadevall, Olivier Hermine
Journal: Ophthalmology (2007)
THE CEILING EFFECT OF GLUTAMIC ACID UPON INTELLIGENCE IN CHILDREN AND IN ADOLESCENTS
Authors: FREDERIC T. ZIMMERMAN, BESSIE B. BURGEMEISTER, TRACY J. PUTNAM
Journal: American Journal of Psychiatry (1948)

1. Glutamic acid accelerates mental functioning in human subjects. 2. The acceleration is general and is not restricted to segments of the intelligence and personality of the individual. 3. The greatest improvement in intelligence and performance test scores occurs within the initial 6 months of treatment, after which the acceleration is diminished and appears to be approaching a ceiling after one year of therapy.
CHRONIC NON-TUBERCULAR AFFECTIONS OF THE LUNG.
Authors: SHERMAN G. BONNEY
Journal: JAMA (1906)

A strict interpretation of the subject embraces the consideration of such an array of conditions as to preclude their profitable discussion within the limits of this paper. A technical construction of what has been assigned would exclude chronic bronchitis and bronchiectasis on the score of their purely bronchial limitation. They almost invariably coexist, however, with emphysema, chronic interstitial pneumonia, pneumonokoniosis and non-tubercular bacterial infections, the clinical manifestations of which it is my purpose to review. No attempt is made to present an exhaustive study of the separate diseases embraced even in this restricted class of chronic pulmonary disorders. In view of the frequent interactive combination of these conditions, a liberal and practical classification is adopted in accordance with the manner of clinical presentation. To this end the thought is directed toward the composite blending of diseased conditions as exhibited in the individual, rather than to distinct affections, which rarely exist
Case 48-1981
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Robert S. Brown, David L. Gang
Journal: New England Journal of Medicine (1981)

Presentation of Case First admission. A 27-year-old man was admitted to the hospital because of renal disease.There was a long history of bronchial asthma. He was otherwise well until three weeks previously, when fever and malaise developed, followed by bilateral lumbar pain, chills, and dysuria. The urine gave a +++ test for protein; the sediment contained innumerable white cells per high-power field. A culture of urine yielded a few colonies of Escherichia coli. Ampicillin was prescribed, with rapid improvement. An intravenous pyelographic examination showed a slightly reduced concentration of contrast material in the nephrographic phase; the renal . . .
Rearrangement and expression of MDM<sub>2</sub> oncogene in chronic lymphocytic leukemia
Authors: Yao Qi Huang, Bruce Raphael, Aby Buchbinder, Jian Jun Li, Wei Gue Zhang, Alvin E. Friedman‐Kien
Journal: American Journal of Hematology (1994)

Abstract Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM 2 has been mapped to this chromosome, we examined the possible association of MDM 2 in the pathogenesis of CLL. A rearrangement of the MDM 2 gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Southern biot hybridization. Expression of MDM 2 was detected in all of the CLL samples examined by Northern blot. However, neither gross amplification nor overexpression of the MDM 2 gene was found in CLL. The data suggest that MDM 2 may play a role in the pathogenesis of CLL and may help to explain how abnormalities of chromosome 12 are related to CLL. © 1994 Wiley‐Liss, Inc.
The Cardiovascular System, vol 1: The Heart
Authors: Irvine H. Page
Journal: JAMA (1980)

An official publication of the American Physiological Society is important.<i>The Heart</i>is the first of a projected five volumes entitled<i>The Cardiovascular System</i>, edited by Robert Berne and Nick Sperelakis. Twenty-five chapters contributed from among the ablest scientists cover normal cardiac function broadly. The utility of this handbook series has already been proved by the first edition,<i>The Handbook of Physiology</i>. All of those concerned with the preparation of this volume have performed admirably, making critical review of each chapter unnecessary. Such massive, expensive, and indepth surveys issued in bound handbooks underscore the persistent problem of communication in rapidly growing fields of knowledge. In this case it is a question of who will derive the most benefit from reading this prodigious work. Although the book is full of material relevant to clinical medicine, I would guess that it will be of most interest to students of physiology and full-time
Chief medical officer's plans for undergraduate education are attacked
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

The debate about who should take responsibility for undergraduate medical education continued this week as the Royal College of Surgeons of England and the body that the chief medical officer favours for the role both agreed that a transfer may not offer any advantages over the current regulator. 

At present the General Medical Council is responsible for setting the medical undergraduate curriculum and approving medical schools. However, in his review of medical regulation published in July ( BMJ 2006;333:163) the chief medical officer for England, Liam Donaldson, recommended that the Postgraduate Medical Education and Training Board (PMETB) should take over the role to create a single regulator for medical education …
Insulin Detemir Is Characterized by a Consistent Pharmacokinetic Profile Across Age-Groups in Children, Adolescents, and Adults With Type 1 Diabetes
Authors: Thomas Danne, Kerstin Lüpke, Kerstin Walte, Wolfgang von Schuetz, Mari-Anne Gall
Journal: Diabetes Care (2003)

OBJECTIVE—This trial aimed to characterize for the first time the pharmacokinetic profile of insulin detemir, the novel soluble basal insulin analog, in children and adolescents compared with adults. Comparisons were also made with NPH insulin to determine any between-treatment difference in the effect of age on pharmacokinetic profile. RESEARCH DESIGN AND METHODS—This single-center, open-label, randomized, crossover trial included children (aged 6–12 years, n = 13), adolescents (aged 13–17 years, n = 10), and adults (aged 18–65 years, n = 11) of both sexes. Subjects were given single doses of 0.5 units/kg s.c. insulin detemir or 0.5 IU/kg NPH insulin on 2 separate days. Serial blood sampling was performed for 24 h for analysis of serum insulin detemir, human insulin, and glucose concentrations. RESULTS—The mean pharmacokinetic profile of insulin detemir was similar across all three age-groups. This was determined by statistical analyses of the data, which showed no overall age effect or between-group differences when pairwise comparisons were made between children (or adolescents) and adults on the parameters of the area under the curve (AUC), AUC from zero to infinity, AUC from 0 to 24 h [AUC(0–24 h)], and the maximum concentration measured during the 24 h after closing. No overall age effect for AUC(0–24 h) and Cmax was detected for NPH insulin, but data were only analyzable from seven adults and pairwise comparisons did indicate that children and adults had different pharmacokinetic profiles. Less total variability in the pharmacokinetics of insulin detemir than NPH insulin was indicated by lower coefficients of variation in AUC, Cmax, and time to maximum concentration in all three age-groups. CONCLUSIONS—The data suggest that insulin detemir can be used in children and adolescents with type 1 diabetes using titration guidelines similar to those used in adults. Moreover, insulin detemir may offer the advantage of greater predictability of response in comparison to NPH insulin due to lower total variability and a lesser degree of kinetic disparity across age-groups.
Rupture of the aorta after mechlorethamine HCl infusion of a bronchial artery
Authors: R. J. Steckel
Journal: JAMA (1967)

PERCUTANEOUS catheterization of the bronchial arteries by the Seldinger technique has been described and is being investigated actively in several centers. 1-7 A special catheter is introduced percutaneously into the femoral artery and is passed proximally in the aorta to the level of the aortic arch. The small bronchial artery orifices arising from the arch or proximal descending aorta can then be entered by the probing catheter tip under fluoroscopic control. This procedure is easily accomplished in the radiology department, and only local anesthesia at the femoral catheterization site is required. Since pulmonary neoplasms, both primary and metastatic, derive their blood supply from the bronchial arteries and not from the pulmonary artery, the technique opens broad new possibilities for the arteriographic diagnosis of pulmonary tumors and for palliative infusions of these tumors with chemotherapeutic agents. 1-9 The following case report describes a fatal complication arising from the infusion of a
Measurement and Modification of the Accuracy of Determinations of Urine Glucose Concentration
Authors: Leonard H Epstein, P Chris Coburn, Dorothy Becker, Allan Drash, Linda Siminerio
Journal: Diabetes Care (1980)

Studies were designed to assess the accuracy of urine glucose testing in a sample of juvenile diabetic subjects, and to determine the effects of a visual discrimination training procedure on the accuracy. In the first study, each of 81 juvenile-diabetic children was presented three prepared glucose solutions and asked to determine the glucose concentration using the 2-Drop Clinitest method. Results showed errors in 54.3% of the judgments, with greatest difficulty occurring with 1-g/dl concentrations. The majority of errors were false negatives. Study II involved similar testing accuracy on a sample of 10 nurses and 2 research technicians, before and after a visual discrimination training procedure. Results showed that the subjects were incorrect on 39% of the trials initially, with a reduction in the error rate to less than 19% after training.
A Longitudinal Study of Medicaid Coverage for Tobacco Dependence Treatments in Massachusetts and Associated Decreases in Hospitalizations for Cardiovascular Disease
Authors: Thomas Land, Nancy A. Rigotti, Douglas E. Levy, Mark Paskowsky, Donna Warner, Jo-Ann Kwass, LeAnn Wetherell, Lois Keithly
Journal: PLoS Medicine (2010)

Thomas Land and colleagues show that among Massachusetts Medicaid subscribers, use of a comprehensive tobacco cessation pharmacotherapy benefit was followed by a substantial decrease in claims for hospitalizations for acute myocardial infarction and acute coronary heart disease.
COMPOUND COMMINUTED FRACTURE AT THE KNEE—REPORT OF A CASE.
Authors: W. A. WARD
Journal: JAMA (1897)

Compound injuries of the knee have at all times been considered most serious in character, more especially when complicated with fracture; in the latter the knife and saw have been considered indispensable, their absence fatal to the life of the patient. Thus Erichsen (System of Surgery) in speaking of this class of injuries of joints, says: "This is more especially the case when the knee is the articulation injured; extensive laceration of this joint, more particularly complicated with dislocation or comminution of the bones, being cases for early amputation." Later Dr. Ashhurst (International Encyclopedia of Surgery) in discussing "Conditions calling for Amputation" places it more mildly by the remark, "Compound fractures into the knee joint may be considered a cause for amputation," yet when taken in connection with the text may almost be considered imperative. Since the days of antiseptics, which may not inaptly be termed the New Surgical Dispensation,