tbuckley/cabot-search huggingface dataset:
Radiation fears prompt possible restrictions on wi-fi and mobile phone use in schools
Authors: R. Watson
Journal: BMJ (2011)

The putative role of IL-4 in human and animal models of hepatitis has not yet been directly determined. We now report that direct expression of IL-4 in the liver of rats or mice using recombinant adenoviruses coding for rat or mouse IL-4 (AdrIL-4 and AdmIL-4, respectively) results in a lethal, dose-dependent hepatitis. The hepatitis induced by IL-4 was characterized by hepatocyte apoptosis and a massive monocyte/macrophage infiltrate. IL-4-induced hepatitis was independent of T cell-mediated immune responses. Hepatitis occurred even after gene transfer of IL-4 into nude rats, CD8-depleted rats, cyclosporine A-treated rats, or recombinase-activating gene 2<sup>−/−</sup> immunodeficient mice. Peripheral depletion of leukocytes using high doses of cyclophosphamide, and/or the specific depletion of liver macrophages with liposome-encapsulated dichloromethylene diphosphonate in rats did not block lethal IL-4-induced hepatitis. Direct transduction of hepatocytes with adenoviruses was not essential, since injection of AdrIL-4 into the hind limb induced an identical hepatitis. Finally, primary rat hepatocytes in culture also showed apoptosis when cultured in the presence of rIL-4. IL-4-dependent hepatitis was associated with increases in the intrahepatic levels of IFN-γ, TNF-α, and Fas ligand. Administration of AdmIL-4 to IFN-γ, TNF-α receptor type I, or TNF-α receptor type II knockout mice also resulted in lethal hepatitis, whereas a moderate protection was observed in Fas-deficient <i>lpr</i> mice. IL-4-dependent hepatocyte apoptosis could be abolished by treatment with caspase inhibitory peptides. Our results thus demonstrate that IL-4 causes hepatocyte apoptosis, which is only partially dependent on the activation of Apo-1-Fas signaling and is largely independent of any immune cells in the liver.
Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: A prospective study
Authors: Alfredo J. Lucendo, Ángel Arias, Livia C. De Rezende, Jose Luis Yagüe-Compadre, Teresa Mota-Huertas, Sonia González-Castillo, Rubén A. Cuesta, José M. Tenias, Teresa Bellón
Journal: Journal of Allergy and Clinical Immunology (2011)
Backup Cameras in Most Vehicles Coming in 2018
Authors: Mike Mitka
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LYMPHATIC CONTRACTILITY
Authors: Ralph O. Smith
Journal: The Journal of Experimental Medicine (1949)

The most peripheral lymphatic vessels of rats, mice, and guinea pigs were found to possess a spontaneous intermittent contractility. (a) The rate of contraction was shown to be directly proportional to the rate of formation of lymph and contractions were apparently initiated by an increase in intraluminal pressure. (b) Epinephrine and pituitrin caused an increased contractile rate, or lymphatic spasm, whereas novocaine caused cessation of movement and lymphatic dilatation. (c) Section or electric stimulation of femoral and sciatic nerves did not alter the contractile rate of popliteal lymphatics. This spontaneous lymphatic contractility was not observed in rabbits and dogs although the lymphatic vessels did contract when irritated. Epinephrine, pituitrin, and novocaine produced the same effects as observed in the smaller mammals. Dilatation of lymphatic vessels produced by intradermal injection of fluid, massage, or passive motion was followed by a rapid return of the vessel to normal caliber. The frequency of valves in lymphatic vessels, the distensibility of the lymphatics, and their ability to return to normal caliber against an increased gradient of pressure are considered to be the essential elements of an intrinsic mechanism contributing to the transport of lymph.
Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs
Authors: Ole D. Mjøs
Journal: Journal of Clinical Investigation (1971)

Myocardial function and oxygen consumption (MV̇O2) were studied during increased myocardial uptake of free fatty acids (FFA) induced by intravenous infusion of a fat emulsion (Intralipid) after heparinization in anesthetized and intact dogs. During raised myocardial uptake of FFA, MV̇O2 increased in all experiments. On the average, MV̇O2 rose from 8.6 to 10.7 ml/min·100 g, or 26% (P < 0.001). This was mainly due to elevated myocardial oxygen extraction, as myocardial blood flow was unchanged, or increased slightly. In the recovery period, MV̇O2 returned to normal. Left ventricular pressure, the maximal rate of rise of left ventricular pressure (dP/dt), heart rate, and cardiac output remained unchanged during the raised myocardial uptake of FFA.
Cyclosporine treatment improves mesenteric perfusion and attenuates necrotizing enterocolitis (NEC)-like intestinal injury in asphyxiated newborn piglets during reoxygenation
Authors: Richdeep S. Gill, Namdar Manouchehri, Tze-Fun Lee, Woo Jung Cho, Aducio Thiesen, Thomas Churchill, David L. Bigam, Po-Yin Cheung
Journal: Intensive Care Medicine (2011)
Influence of Induced Hypothermia on Digitalis Toxicity
Authors: E. T. ANGELAKOS, H. I. HURWITZ
Journal: Circulation Research (1961)

Toxic doses of ouabain were injected in animals which were subsequently cooled. The mortality- in this group was compared to that of similarly treated controls. Lowering of body- temperature by 8 to 12 C. reduced the arrhythmias produced by the toxic doses of ouabain but did not alter the overall incidence of mortality from ventricular fibrillation when compared to the controls. However, cooled animals survived for considerably longer periods of time than the normothermic controls. It is concluded that subsequently induced hypothermia does not afford an effective protection from digitalis toxicity, even though arrhythmias are reduced and survival is prolonged. These results support the hypothesis that partial protection from ventricular arrhythmias is not necessarily associated with, protection from lethal ventricular fibrillation.
Magnetic Resonance Imaging–Transectal Ultrasound Image-fusion Biopsies Accurately Characterize the Index Tumor: Correlation with Step-sectioned Radical Prostatectomy Specimens in 135 Patients
Authors: Eduard Baco, Osamu Ukimura, Erik Rud, Ljiljana Vlatkovic, Aud Svindland, Manju Aron, Suzanne Palmer, Toru Matsugasumi, Arnaud Marien, Jean-Christophe Bernhard, John C. Rewcastle, Heidi B. Eggesbø, Inderbir S. Gill
Journal: European Urology (2014)
Particle Tracking Analysis for the Intracellular Trafficking of Nanoparticles Modified with African Swine Fever Virus Protein p54-derived Peptide
Authors: Hidetaka Akita, Kaoru Enoto, Hiroki Tanaka, Hideyoshi Harashima
Journal: Molecular Therapy (2012)

Previous studies showed that the cytoplasmic transport of nanoparticles to the nucleus is driven by a vesicular sorting system. Artificial approaches for targeting a microtubule-associating motor complex is also a challenge. We describe herein the development of a liposomal nanoparticle, the surface of which is modified with stearylated octa-arginine (STR-R8), and a dynein light chain (LC8)-associated peptide derived from an African swine fever virus protein p54 (p54(149-161)) with polyethyleneglycol (PEG) as a spacer (p54(149-161)-PEG/R8-liposomal nanoparticles (LNPs)). The p54(149-161)-PEG/R8-LNPs preferentially gain access to the nucleus, resulting in a one- to two-order of magnitude higher transfection activity in comparison with p54(149-161)-free nanoparticles (PEG/R8-LNPs). Further studies of particle tracking in HeLa cells stably expressing green fluorescent protein (GFP)-tagged tubulin (GFP/Tub-HeLa) indicate that p54(149-161) stimulated the transport of nanoparticles along fibrous tubulin structures. Moreover, a part of the p54(149-161)-PEG/R8-LNPs appeared to undergo quasi-straight transport without sharing the tracks corresponding to PKH67, the plasma membrane of which had been prestained with a marker just before transfection, while corresponding movement was never observed in the case of PEG/R8-LNPs. These findings suggest that a portion of the p54(149-161)-modified nanoparticles can use microtubule-dependent transport without the need for an assist by a vesicular sorting system.
New PHS Agency To Set Treatement Guidelines
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article New PHS Agency To Set Treatement Guidelines Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 13, 4 July 1990, Pages 1086–1087, https://doi.org/10.1093/jnci/82.13.1086 Published: 04 July 1990
Intersex and Abnormalities of Autosomes and Blood-Group Inheritance in a Kindred
Authors: Raymond J. Caffrey
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Life and Letters of Dr. Henry Vining Ogden 1857-1931
Authors: Earl F. Nation
Journal: JAMA (1987)

The title of this book, while appropriate, will not appeal to as large an audience as does the text. It is a book of regional medical interest but much more. All Oslerians will find it a rich mine of information, much of it personal, about the "Beloved Physician." Most of those interested in the local aspects will probably be aware of the book. The larger audience, the Oslerians and others interested in Osier's era of medical education and practice, should be made aware of it. Those who are familiar with Harvey Cushing's great Pulitzer Prize-winning biography of Sir William Osler may remember the name Henry Vining Ogden. Few know that Cushing said his single greatest source of information, particularly about Osier's early life, was Dr Ogden and his correspondence with his friend William Osler. Fifty-nine letters from Osler and Cushing to Ogden are in the collections of the Milwaukee Academy
OPSONINS AND THE USE OF THERAPEUTIC VACCINES IN TREATING GENERAL PARALYSIS OF THE INSANE.
Authors: JOHN D. O'BRIEN
Journal: JAMA (1907)

spinal cord symptom; in not a few instances the patients complain of numbness and tingling in the fingers, even before the attention is called to the appearance of pallor, weakness, etc.There is another symptom noticed, the symptom to which Hunter called attention, the sore mouth and sore tongue.The more one looks for this in cases of pernicious anemia, the more often will it be noted.Therefore, Dr. Herrick believed that while we should not neglect a careful blood examination, we should pay more attention to the paresthesias and other subjective symptoms which might ultimately enable us to es- tablish fairly definitely a symptom-complex of the disease.Dr. W. S. Thayer, Baltimore, insisted that pernicious anemia is much more common than is generally supposed.He emphasized the importance of paying attention to the early nervous signs.Paresthesia is perhaps the earliest symptom complained of.Dr. Thayer gave illustrative cases.Dr. G. W. McCaskey, Fort Wayne, Ind., said that he be- lieves it to be a reasonable assumption that pernicious anemia is due to some toxic condition.It is often due to changes
Physician Compensation, Cost, and Quality
Authors: Robert H. Brook
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TREATMENT OF HARE-LIP
Authors: H. F. MacAuley
Journal: BMJ (1925)

TREATMENT OF HARE-LIP.tDDxJ*w""253 ideal to be 'aimed at.In effect that method provided a supply of milk of which 2 per cent.came from tuberculin tested cows, and was sold at a price which was beyond the pocket of the average consumer: the remaining 98 per cent, was pasteurized milk.He wished to point out; that there was an' alternative to this which had been found to be very'successful in those districts in which it had received adequate support-namely, the prod'uction of Grade A tuberculin tested milk, the price of which was very much less than that of certified milk.In the town of Reading this milk formed not less than one-sixth of the total supply of the town, was sold without treatment, and was purchased bv the poor in quantities at least equal to those whiich were purchased by the rich.Dr. C. A. MORTLOCK-BROWN (Braunton) called attention to the need for a clean water supply and an incinerator on dairy farms.Mr. WILFRED BUCKLEY, in reply, said that lhe proposed in future to test hiis cattle for tuberculosis-once by the subcutanieous metlhod and once by the intradermal.He
A STUDY OF THE ACTION OF CALCIUM IN EXPERIMENTAL COCAIN POISONING
Authors: SOMA WEISS
Journal: JAMA (1923)

Some time ago, Dr. Emil Mayer, chairman of the Committee for the Study of Toxic Effects of Local Anesthetics, called my attention to a paper by Karl Mayer 1 and one by Hofvendahl, 2 with a request that a report on their results be prepared for the committee. Shortly after my report was submitted to Dr. Mayer, the chairman of the committee, a paper was published by Frank, Strauss and Smiley 3 in which they stated that they were unable to observe any antagonistic action of calcium toward cocain, such as Karl Mayer had reported. They offered no explanation of the discrepancy between their results and those of Mayer, and it seems desirable, therefore, to publish the result of my investigation and to explain the discrepancy mentioned.  Karl Mayer's work is fundamentally faulty, so far as one can judge from his paper, in that he did not determine the fatal
Metastatic Tumors of the Central Nervous System
Authors: Julian T. Hoff
Journal: JAMA (1982)

Metastatic tumors of the CNS are increasing in importance as clinicians treat primary tumors more aggressively and life expectancy of patients with metastatic disease lengthens. This text reviews the basis for changing attitudes about metastatic tumors and outlines current diagnostic and therapeutic approaches to patients with a variety of neoplasms.  The book is written by three neurosurgeons and a neuropathologist (Hirano). Two of the six chapters review the pathology of metastatic tumors of the CNS, based on a study of 8,000 autopsies at the Montefiore Hospital in New York. Chapter 2, concerning the pathology of metastases affecting the CNS, is well written and beautifully illustrated. This chapter alone is worth the price of the book. Chapter 5, concerning metastases within the spinal canal, is also nicely done.  Clinical experience with 616 patients, managed by various means at the University of Tokyo, is described in detail in chapters 3 and 4.
A handout about tetanus immunisation: influence on immunisation rate in general practice.
Authors: C J Cates
Journal: BMJ (1990)

To assess the influence of giving patients a handout about tetanus immunisation on the rate of immunisation against tetanus among adults in a general practice.Monthly tetanus immunisation rates were audited before and after the handout was introduced.A practice with six doctors and a list of 11,000 patients in an urban area of Hertfordshire.In the first month reception staff were instructed to give a handout about tetanus immunisation to all adults presenting at the reception desk. In the next seven months the doctors used the handouts opportunistically during consultations.No significant change in immunisation rate was detected in the first month in which the handouts were used. During the next seven months the median monthly rate rose threefold.Handouts given to patients can increase the uptake of preventive services in general practice.
DO MEDICAL STUDENTS "FAIL?"
Authors: CHARLES W. SCHLAGETER
Journal: American Journal of Psychiatry (1963)

Records of all the medical students who left the Northwestern University Medical School during the 5-year period 1955-1960 were studied. Their average pre-medical grades and medical college aptitude test scores when compared to the same averages of the entire entering freshman classes for those years showed no statistically significant differences. Psychiatric interviews were available in 18 of the 43 students who left and did not return to school. The significance of a student leaving school whether by academic failure or voluntary resignation is discussed. It is suggested that students leave medical school, no matter by what route, as a way of coping with anxiety engendered by their presence in school.
Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats.
Authors: J Holoshitz, A Matitiau, I R Cohen
Journal: Journal of Clinical Investigation (1985)

Adjuvant arthritis is an experimental disease of rats induced by immunization to antigens of Mycobacterium tuberculosis. Our observation that arthritis could be induced in irradiated rats by the A2 line of T lymphocytes in the absence of mycobacterial antigens suggested that adjuvant arthritis is an autoimmune disease. Moreover, the A2 line could be used to vaccinate unirradiated rats against the subsequent induction of adjuvant arthritis by active immunization to Mycobacteria. In the present study we found that thymus cells obtained from A2 vaccinated rats could transfer resistance to adjuvant arthritis to naive rats. This indicates that the mechanism of resistance induced by A2 vaccination is probably immunological and involves thymus-derived lymphocytes.
Rate of Change in Aortic Valve Area During a Cardiac Cycle Can Predict the Rate of Hemodynamic Progression of Aortic Stenosis
Authors: Steven J. Lester, Doff B. McElhinney, Joseph P. Miller, Juergen T. Lutz, Catherine M. Otto, Rita F. Redberg
Journal: Circulation (2000)

The ability to predict the rate of hemodynamic progression in an individual patient with valvular aortic stenosis has been elusive. The purpose of the present study was to evaluate whether the rate of change in aortic valve area (AVA) measured during the ejection phase of a cardiac cycle predicts the rate of hemodynamic progression in patients with asymptomatic aortic stenosis.In 84 adults with initially asymptomatic aortic stenosis and a baseline AVA of > or =0.9 cm(2), annual echocardiographic data were obtained prospectively (mean follow-up 2.8+/-1.3 years). With the initial echocardiogram, the ratio of AVA measured at mid-acceleration and mid-deceleration to the AVA at peak velocity was calculated. The primary outcome variable was the annual rate of change in AVA (rate of progression), with rate of progression classified as rapid (a reduction in AVA of > or =0.2 cm(2)/y) or slow (<0.2 cm(2)/y). Rapid progression was significantly associated with an AVA ratio of > or =1.25 (P=0.004, risk ratio 3.1, 95% CI 1.2 to 7.9). The sensitivity, specificity, and positive predictive value of AVA ratio of > or =1.25 for the prediction o rapid progression of valvar aortic stenosis was 64%, 72%, and 80% respectively. The decrease in ejection fraction measured from the initial to final echocardiogram was small but greater for patients with an AVA ratio of > or =1.25 (-4+/-7% versus +2+/-7%, P<0.001).A flow-dependent change in AVA can be measured during a routine transthoracic echocardiographic study. The rate of change in AVA is an additional measure of disease severity and may be used to predict an individual's risk for subsequent rapid disease progression.
Sumatriptan: A Receptor-Targeted Treatment for Migraine
Authors: Michael A. Moskowitz, F. Michael Cutrer
Journal: Annual Review of Medicine (1993)

Sumatriptan, recently introduced for the treatment of migraine, heralds the beginning of a molecular era in the pharmacological treatment of migraine headache. An indole (non-ergot alkaloid) derivative with agonist properties at a receptor resembling the 5-HT1D subtype (so-called 5-HT1-like receptor), sumatriptan is the first antimigraine medication to exhibit receptor-selective properties. Clinical data indicate that sumatriptan relieves headache, nausea, and photophobia in a majority of acute migraine patients, and it possesses favorable side effect and safety profiles. Of great importance, sumatriptan acts through a novel mechanism that we now know is shared by dihydroergotamine and other useful compounds for the treatment of acute migraine headaches. In this summary, we briefly review the drug's mechanism of action and the emerging clinical experience with its use.