tbuckley/cabot-search huggingface dataset:
Abstract P6-12-06: Oral Vinorelbine and Capecitabine Plus Bevacizumab in Recurrent Inflammatory Breast Cancer: Gene Profiling and Response to Treatment
Authors: L Fumagalli, G Curigliano, M Locatelli, V Bagnardi, F Bertolini, P Mancuso, S Giudici, A. Goldhirsch
Journal: Cancer Research (2010)

Abstract Background: Therapies that target vasculolymphatic processes - angiogenesis, lymphangiogenesis, and vasculogenesis — have shown potential in the treatment of inflammatory breast cancer. Methods: We randomly assigned 46 patients to receive oral vinorelbine 55 mg per square meter of body surface on days 1 and 3 and capecitabine 2000 mg per square meter on days 1 to 14 every 3 weeks either concurrent or sequential to bevacizumab 15 mg per kilogram of body weight on days 1 and 21 (BEVIX). The primary end point was progression-free survival; the response rate and overall survival were a secondary end point. For correlative studies we collected baseline tissue and blood samples of all patients. Gene expression profiling was performed using Affymetrix HG-U133 Plus 2.0 arrays. Data were analyzed using Partek Genomic Suite 6.4 and GeneSpring 7.0. Tissue from normal breast was used as control. Results: From July 2007 through January 2010, a total of 46 patients were enrolled. Concurrent oral vinorelbine and capecitabine plus bevacizumab significantly increased the objective response rate as compared to the sequential treatment (11.1% vs. 46.4%, p=0.025). No difference in progression-free survival was observed between the two arms (median time to progression 4.3 vs. 4.7 months, p=0.69; Hazard Ratio: 0.86, 95% CI: 0.41-1.80). The median overall survival was 9.1 months in concurrent arm and 15.8 months in sequential arm, (p=0.43). Global gene expression was analyzed in tumor samples from 18 pts bearing a triple negative phenotype. This cohort displayed a specific gene expression profile, including high expression levels of several cytokeratins, Aurora kinase A, Cyclin E and others, similar to the basal-like subtype. This profile did not include genes previously reported as differentially expressed in inflammatory breast cancers. We identified a set of 75 genes whose expression correlates with response to bevacizumab base therapy. Conclusions: BEVIX is an active treatment for patients with recurrent inflammatory breast cancer. These tumors showed a gene expression pattern similar to that of basal-like type. We identified a set of 75 genes whose expression levels predict the response to BEVIX. The validity of this expression signature is currently being assessed. Supported by Roche and Associazione Italiana per la Ricerca sul Cancro (AIRC) grants. Data partially submitted to 2010 ASCO Meeting Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-12-06.
A NEW NASAL SPECULUM.
Authors: O. B. MONOSMITH
Journal: JAMA (1903)

Realizing that the bivalve speculum, opening transversely, did not meet all of the requirements of a nasal speculum, I was led to devise one for my own use that would overcome these difficulties. That I have succeeded, at least to my own satisfaction, is the excuse for presenting it to the profession. Its evolution extended over a period of about three years, during which time I made many modifications. The model, a cut of which I present, I have used about a year, and, in the majority of nares, it meets all of the requirements of an ideal speculum, both diagnostic and operative. It has merits that will appeal to the specialist as well as the general practitioner. The instrument is to be held in the left hand of the operator for both nares, with the ball of the thumb on the screw head, thus
Law, Medicine, and the "Gag Rule"
Authors: John R. Ball
Journal: Annals of Internal Medicine (1991)

Editorials1 September 1991Law, Medicine, and the "Gag Rule"John R. Ball, MD, JDJohn R. Ball, MD, JDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-5-403 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Supreme Court of the United States, in Rust v. Sullivan (1), decided late this spring that regulations prohibiting counseling concerning abortion in federally funded family planning clinics (the "gag rule") were valid. Whatever one's personal views about abortion and on whichever end of the political spectrum one stands, both the decision and the reasoning behind it should raise broad alarm. The decision's rationale has implications for society and for medical care far beyond the specific effect of the decision on family planning clinics, the people who work there, and their patients.The interface of two cultures, like the tidal...References1. Irving Rust, et al. v. Louis W. Sullivan, Secretary of Health and Human Services, — U.S. — (1991). Google Scholar2. Edward J. DeBartolo Corp. v. Florida Gulf Coast Building & Construction Trades Council, 485 U.S. 568, 575 (1988). Google Scholar3. Rust, supra, quoting Harris v. McRae, 448 U.S. 297, 316 (1980). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John R. Ball, MD, JDAffiliations: Philadelphia, PA 19106 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byP 1 September 1991Volume 115, Issue 5 Page: 403-404 Keywords Reasoning ePublished: 1 December 2008 Issue Published: 1 September 1991 PDF downloadLoading ...
GPs want longer consultations, BMA survey finds
Authors: A. Rimmer
Journal: BMJ (2015)

GPs want more time to treat their patients, a survey of the profession has found. 

The survey of GPs’ work, carried out by IMC Unlimited on behalf of the BMA, received 15 560 responses from GPs across the United Kingdom.1 The BMA has described it as one of the largest recent tests of the profession’s opinion. 

It found that less than a 10th of GPs (8%) thought that the standard 10 minute consultation in general practice was adequate. Around two thirds (68%) of respondents thought that it would be better to provide longer consultations of greater quality, even …
S55 Cost-effectiveness and quality of life results from the ASTER study: endobronchial and endoscopic ultrasound vs surgical staging in potentially resectable lung cancer
Authors: R. C. Rintoul, J. T. Annema, K. G. Tournoy, C. Dooms, E. Wheaton, V. Hughes, A. Grant, G. Griffith, M. Buxton, L. Sharples
Journal: Thorax (2011)

<h3>Background</h3> We recently published clinical results of ASTER, a randomised controlled trial in which endosonography, a strategy of combined endoscopic (EUS) and endobronchial (EBUS) ultrasound (followed by surgical staging if these tests were negative for malignancy), had significantly higher sensitivity and negative predictive value than surgical staging alone for mediastinal staging in NSCLC. Here we present ASTER quality of life (QoL) and cost-effectiveness outcomes. <h3>Methods</h3> EuroQoL EQ-5D questionnaire was performed at baseline, end of staging, 2 and 6 months post randomisation. The UK EQ-5D social tariff was applied to calculate utility values. Quality-adjusted survival was estimated using the area under the utility curve. Full resource use information was recorded for all patients and NHS 2008–2009 Reference Costs were applied. Total expected costs over 6 months were estimated by summing the resource use multiplied by its unit cost and taking the sample average for each group. <h3>Results</h3> Of 241 randomised patients, 144 (60%) provided EQ-5D data at baseline; of these 139 (97%) were followed up at the end of staging, 132 (92%) at 2 months and 124 (86%) at 6 months. At the end of staging, those randomised to endosonography had significantly better QoL than those randomised to surgical staging (utility difference=0.11, 95%CI 0.02 to 0.19). At all other time points, there was little difference between the groups, so that quality adjusted survival over the 6 months was similar (4.1 vs 4.0 months respectively). Complete resource use data were available for 172/214 (71%) patients. Other than the number of thoracotomies performed (66% of patients in the surgical staging arm and 53% in the endosonography arm) resource use did not differ between the two groups. The endosonography group had a non-significant cost saving of £746 per patient compared to the surgical staging group. <h3>Conclusions</h3> Given that (a) the sensitivity of endosonography was significantly higher than that of the surgical staging arm; (b) QoL post-staging was higher in the endosonography arm and (c) there is no difference in cost between the two strategies, mediastinal staging should commence with endosonography proceeding to surgical staging if there is no evidence of malignancy.
Renal bicarbonate reabsorption in the rat. I. Effects of hypokalemia and carbonic anhydrase.
Authors: G Capasso, R Kinne, G Malnic, G Giebisch
Journal: Journal of Clinical Investigation (1986)

Free-flow micropuncture studies were carried out on superficial rat proximal and distal tubules to assess the participation of different nephron segments in bicarbonate transport. Particular emphasis was placed on the role of the distal tubule, and micro-calorimetric methods used to quantitate bicarbonate reabsorption. Experiments were carried out in control conditions, during dietary potassium withdrawal, and after acute intravenous infusions of carbonic anhydrase. We observed highly significant net bicarbonate reabsorption in normal acid-base conditions as evidenced by the maintenance of significant bicarbonate concentration gradients in the presence of vigorous fluid absorption. Distal bicarbonate reabsorption persisted in hypokalemic alkalosis and even steeper transepithelial concentration gradients of bicarbonate were maintained. Enhancement of net bicarbonate reabsorption followed the acute intravenous administration of carbonic anhydrase but was limited to the nephron segments between the late proximal and early distal tubule. The latter observation is consistent with a disequilibrium pH along the proximal straight tubule (S3 segment), the thick ascending limb of Henle, and/or the early distal tubule.
Disease, Drug Response Linked to Loss or Gain of Big DNA Chunks in Genome
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nocardia asteroides Sinusitis
Authors: Paul Katz, Anthony S. Fauci
Journal: JAMA (1977)

A patient with a yearlong fever of unknown origin responded to trimethoprim-sulfamethoxazole and was discovered to have culture-proved<i>Nocardia asteroides</i>sinusitis, with absence of detectable disease in other organs. An inhalational route is postulated as the mode of entry of the organism, with localization in the maxillary sinus. <i>JAMA</i>238:2397-2398, 1977)
Hypothermia: Pathophysiology, Clinical Settings, and Management
Authors: JAMES B. REULER
Journal: Annals of Internal Medicine (1978)

Hypothermia, defined as a core temperature less than 35 °C, is frequently not recognized, in part because of the inadequacy of standard thermometers. This entity has multiple causes and unique pathophysiologic consequences that complicate diagnosis and treatment. Understanding of the physiology of thermoregulation is important in light of recent advances in therapy using core rewarming. Pathophysiology, etiology and management of the hypothermia syndrome are reviewed.
Delayed haemorrhagic disease of the newborn.
Authors: A Minford, O B Eden
Journal: BMJ (1979)

0 1 2 3 4 5 6 7 8 9 Days since transplantation Serum creatinine concentration by time.figure are transformed back into the original units serum creatinine concentrations change smoothly with time.A quadratic curve fits the data reasonably well, although a more appropriate model might be to fit separate exponential curves to the periods of improvement and deterioration.It is hard to see why they have chosen to use the artificial method of taking reciprocals rather than study the raw data.The authors rightly say that "a time when renal allograft rejection occurs can be determined only if there is a sudden event rather than slow changes from a non-rejecting to a rejecting state."I cannot accept that they have established this.Lastly, their approach assumes that onset of rejection results in an immediate rise in serum creatinine.Is this really so ?
AbbVie considers harms to be commercially confidential information: sign a petition
Authors: P. C. Gotzsche
Journal: BMJ (2013)

In 2010, the Nordic Cochrane Centre got access to clinical study reports and trial protocols at the European Medicines Agency (EMA) after filing a complaint to the European ombudsman, who concluded that these documents do not contain commercially confidential information.1 2

Since December 2010, the EMA has released more than 1.5 million pages on clinical information about medicinal products. However, in the spring of 2013, two US drug companies, AbbVie and InterMune, challenged the EMA’s new openness policy at the European …
STUDIES ON THALASSEMIA PART I. AN EXTRACORPUSCULAR DEFECT IN THALASSEMIA MAJOR PART II. THE EFFECTS OF SPLENECTOMY IN THALASSEMIA MAJOR WITH AN ASSOCIATED ACQUIRED HEMOLYTIC ANEMIA12
Authors: Herbert C. Lichtman, R. Janet Watson, Felix Feldman, Victor Ginsberg, Jean Robinson
Journal: Journal of Clinical Investigation (1953)
Letter: Reorganization and nurse training.
Authors: C Fairweather
Journal: BMJ (1975)

biopsy of patients or hyperthermic indiividuals would provide material of doubtful value for detailed biochemical investigations in vitro.We have used nitrous oxide in conjunction with thiopentone to anaesthetize more than 150 susceptible pigs without triggering M.H.Our experience in pigs therefore appears to conflict with that of Ellis et al.} which incriminated nitrous oxide in a single human patient.This suggests that the aetiology is not entirely a pharmacological effect but may be associated with some other aspect of anaesthesia.The observation of Ellis et al. that M.H. may be satisfactorily treated with large doses of glucocorticoids will no doubt lead to the development of several hypotheses on the mode of action of these drugs, as occurred following the use of procaine.It should also be remembered that when no specific therapy could be recommended 36% of the patients survived.9Thus isolated case reports should be considered with caution until any new therapy can be critically appraised.'0-We are, etc.,
Toxic epidermal necrolysis in a patient receiving vemurafenib for treatment of metastatic malignant melanoma
Authors: R. Sinha, K. Lecamwasam, K. Purshouse, J. Reed, M.R. Middleton, L. Fearfield
Journal: British Journal of Dermatology (2013)

Journal Article Toxic epidermal necrolysis in a patient receiving vemurafenib for treatment of metastatic malignant melanoma Get access R. Sinha, R. Sinha Department of Dermatology Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH U.K E‐mail: rs280@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar K. Lecamwasam, K. Lecamwasam Department of Dermatology Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH U.K Search for other works by this author on: Oxford Academic Google Scholar K. Purshouse, K. Purshouse Department of Oncology University of Oxford Oxford U.K Search for other works by this author on: Oxford Academic Google Scholar J. Reed, J. Reed Department of Oncology University of Oxford Oxford U.K Search for other works by this author on: Oxford Academic Google Scholar M.R. Middleton, M.R. Middleton Department of Oncology University of Oxford Oxford U.K Search for other works by this author on: Oxford Academic Google Scholar L. Fearfield L. Fearfield Department of Dermatology Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 4, 1 April 2014, Pages 997–999, https://doi.org/10.1111/bjd.12796 Published: 01 April 2014
P3-164: A phase II trial of pemetrexed(p) in patients (pts) with performance status (PS) 2 and 3 as 1st– and 2nd– line treatment for advanced non–small–cell lung cancer (NSCLC)
Authors: Ralph G. Zinner, Frank V. Fossella, Merrill Kies, Roy S. Herbst, Charles Lu, Faye Johnson, Justina Price, Charles Cleeland, Shirley Wang
Journal: Journal of Thoracic Oncology (2007)
Transmission of Enteric Pathogens by Barium Enemas
Authors: Howard L. Steinbach
Journal: JAMA (1960)

After performing barium enemas, we have noted repeatedly the presence of feces in residual barium sulfate. The plastic tubing used in preparatory enemas, therefore, was closely observed, and in many cases feces and mucus were seen to pass from the rectum into the tube for varying distances, sometimes all the way into the enema can. Since for the next patient only the enema tip was discarded and replaced, it became obvious that we were contaminating some patients with rectal contents from patients previously examined.  Radiologists in different parts of the country were queried about their methods of preventing cross-contamination of patients. Their replies indicated that in the majority of institutions and private offices the rectal tubes are changed and either washed, discarded, or sterilized. More barium sulfate is added to the residue for the examination of the next patient. Only occasionally is the barium sulfate discarded and the can and
Treatment of Cancer of Cervix by Radium and Deep X-Rays
Authors: George W. Waterman, Sumner I. Raphael
Journal: New England Journal of Medicine (1950)

THE purpose of this paper is to report to the New England Surgical Society the results of treatment of cancer of the cervix at the Rhode Island Hospital from 1933 through 1943. The year 1933 is chosen as a starting point because in that year the use of deep x-ray therapy as a part of the "planned treatment" was inaugurated.Four hundred and thirty-two consecutive cases of cancer of the cervix are found in the clinical files for this period. From a study of five-year and ten-year survival rates in this series of cases, we hope to draw conclusions regarding . . .
Genetic and Molecular Ecotoxicology: A Research Framework
Authors: Susan Anderson, Walter Sadinski, Lee Shugart, Peter Brussard, Michael Depledge, Tim Ford, JoEllen Hose, John Stegeman, William Suk, Isaac Wirgin, Gerald Wogan
Journal: Environmental Health Perspectives (1994)

Participants at the Napa Conference on Genetic and Molecular Ecotoxicology assessed the status of this field in light of heightened concerns about the genetic effects of exposure to hazardous substances and recent advancements in our capabilities to measure those effects. We present here a synthesis of the ideas discussed throughout the conference, including definitions of important concepts in the field and critical research needs and opportunities. While there were many opinions expressed on these topics, there was general agreement that there are substantive new opportunities to improve the impact of genetic and molecular ecotoxicology on prediction of sublethal effects of exposure to hazardous substances. Future studies should emphasize integration of genetic ecotoxicology, ecological genetics, and molecular biology and should be directed toward improving our understanding of the ecological implications of genotoxic responses. Ecological implications may be assessed at either the population or ecosystem level; however, a population-level focus may be most pragmatic. Recent technical advancements in measuring genetic and molecular responses to toxicant exposure will spur rapid progress. These new techniques have considerable promise for increasing our understanding of both mechanisms of toxicity on genes or gene products and the relevance of detrimental effects to individual fitness. — Environ Health Perspect 102(Suppl 12):3–8 (1994)
DANGER OF INTRAVENOUS MERCURIAL INJECTIONS IN NEPHROSIS
Authors: MARY CATHERINE TYSON
Journal: JAMA (1941)

Mercurial diuretics have been used freely for more than a dozen years. Poll and Stern<sup>1</sup>have emphasized the dangers of extreme dehydration from overenthusiastic use of these drugs, and Greenwald and Jacobson<sup>2</sup>have presented 2 cases and Wolf<sup>3</sup>a third case of sudden death following an intravenous injection of a mercurial diuretic. I wish to present 2 further cases and to point out the striking similarities in all 5 cases. Greenwald and Jacobson's first case was that of a child aged 2 years with nephrosis who was given 0.5 cc. of neptal (a mercurial diuretic<sup>4</sup>) intramuscularly, followed by 1 cc. intramuscularly four days later. One week later 1 cc. of neptal given intravenously caused dyspnea, cyanosis, cardiac standstill and death within one minute of injection. Their second case was that of a child aged 3 years with nephrosis who received 0.5 cc. of neptal intravenously followed
Skin Color as a Clinical Datum
Authors: HENRY ROTHSCHILD
Journal: Annals of Internal Medicine (1979)

Letters1 February 1979Skin Color as a Clinical DatumHENRY ROTHSCHILD, M.D., PH.D., FRED M. HUNTER, M.D.HENRY ROTHSCHILD, M.D., PH.D.Search for more papers by this author, FRED M. HUNTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-280_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Mansbach and colleagues (1) in a brief report mention the patient's skin color twice within two paragraphs but give little other sociologic, economic, or genetic information. Skin color as a designation of race is an arbitrary sociologic classification and rarely, if ever, adds to our diagnostic, pathogenic, or therapeutic knowledge. Some journals now remove references to race in articles to be published, except of course, where race has, or may have, implications for the acquisition, course, or treatment of a disease. Our knowledge of a patient's history would be better served if his race, when pertinent, were...Reference1. MANSBACHSHELBURNESTEVENSDOBBINS CJRW: Lymph-node bacilliform bodies resembling those of Whipple's disease in a patient without intestinal involvement. Ann Intern Med 89:64-66, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisiana State University Medical Center New Orleans, LA 70112 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySkin Color and Race in Clinical MedicineMICHAEL GUTWEIN, M.D. 1 February 1979Volume 90, Issue 2Page: 280-280KeywordsClinical geneticsPathogensRacial and ethnic issues Issue Published: 1 February 1979 PDF DownloadLoading ...