tbuckley/cabot-search huggingface dataset:
A Sign of Heroin Use in Methadone Programs
Authors: Robert Tarail
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Our counselors have accurately suspected secret use of heroin by noting a puffy face in clients maintained on methadone in our clinic. This observation stimulated me to pay heed to the phenomenon myself and then to report it. The syndrome has not as far as we know been described before. The symptoms and signs are edema (face, extremities, and abdomen), arthritis, arthalgia (swelling, stiffness, pain, limitation of motion of fingers, wrists, and sometimes elbow or knee), and general sluggishness. Uniformly, such a client has been using heroin in addition to prescribed methadone. After heroin use stops (though methadone use continues), the disorder recedes. The syndrome has been observed in a substantial fraction of clients who consistently abuse heroin while receiving methadone. Ages range from about 20 to 50 years. We suspect that the combination of the synthetic relative of opium (methadone) when mixed in the appropriately sensitive
TCT-572 Impact of calcium-deposit for left circumflex ostium narrowing after crossover stenting in distal left main bifurcation: An Intravascular Ultrasound Study in the Milan and Fukuyama Registry.
Authors: Katsumasa Sato, Toru Naganuma, Hideo Takebayashi, Kenji Goto, Charis Costopoulos, Tadashi Miyazaki, Azeem Latib, Seiichi Haruta, Antonio Colombo
Journal: Journal of the American College of Cardiology (2013)
Plasma and Urinary 11-Hydroxycorticosteroids in Differential Diagnosis of Cushing's Syndrome
Authors: D. Mattingly, C. Tyler
Journal: BMJ (1972)

Morning plasma 11-hydroxycorticoids, urinary 11-hydroxycorticoids, and urinary 17-oxogenic steroids were measured before and during a dexamethasone suppression test. This consisted in the administration by mouth of 2 mg of dexamethasone daily for 48 hours, followed by 8 mg daily for 48 hours. In addition midnight plasma 11-hydroxycorticoids were measured before the start of the test. The subjects investigated were 21 patients with Cushing's syndrome, 27 obese female patients, 10 female patients with the Stein-Leventhal syndrome, and 8 female patients with idiopathic hirsutism.The results showed that the clearest distinction between the groups was made by measurement of the basal urinary 11-hydroxycorticoid excretion, where, in the group of patients with Cushing's syndrome, all the levels were well above the upper limit of normal. In addition raised midnight plasma 11-hydroxycorticoid levels were of great diagnostic value. By using these results together with those of the dexamethasone suppression tests it was possible to make a firm preoperative diagnosis of pituitary-dependent Cushing's syndrome in 90% of patients in this series.
The impact of cellular senescence and DNA damage on colorectal tumour progression
Authors: Helen K Angell, Marie Tosolini, Bernhard Mlecnik, Gabriela Bindea, Tessa Fredriksen, Lucie Lafontaine, Maximilian Waldner, Franck Pagès, Viia Valge-Archer, Jérôme Galon
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts We have previously defined the immune contexture as the type, density, location and functional orientation of tumour infiltrating immune cells, associated with patient prognosis in colorectal cancer (CRC). Here we describe potential mechanisms, including the DNA damage response (
Corticosteroids in Ophthalmology
Authors: A. C. Shuttleworth
Journal: BMJ (1960)

<h3>Abstract</h3> CTCF is the most likely ancestor of proteins that contain large clusters of C2H2 zinc finger domains (C2H2) and is conserved among most bilateral organisms. In mammals, CTCF functions as the main architectural protein involved in the organization of topology-associated domains (TADs). In vertebrates and <i>Drosophila</i>, CTCF is involved in the regulation of homeotic genes. Previously, null mutations in the <i>dCTCF</i> gene were found to result in death during the stage of pharate adults, which failed to eclose from their pupal case. Here, we obtained several new null <i>dCTCF</i> mutations and found that the complete inactivation of dCTCF appears to be limited to phenotypic manifestations of the <i>Abd-B</i> gene and fertility of adult flies. Many modifiers that are not associated with an independent phenotypic manifestation can significantly enhance the expressivity of the null <i>dCTCF</i> mutations, indicating that other architectural proteins are able to functionally compensate for dCTCF inactivation in <i>Drosophila</i>. We also mapped the 715–735 aa region of dCTCF as being essential for the interaction with the BTB (Broad-Complex, Tramtrack, and Bric a brac) and microtubule-targeting (M) domains of the CP190 protein, which binds to many architectural proteins. However, the mutational analysis showed that the interaction with CP190 was not essential for the functional activity of dCTCF <i>in vivo</i>. <h3>Highlights</h3> The dCTCF 715–735 aa region interacts with the BTB and M domains of CP190 Interaction with CP190 is not essential for dCTCF function <i>in vivo</i> Null <i>dCTCF</i> mutants are viable but show severely reduced fertility
Illness in Returned Travelers
Authors: Paul D. Blanc
Journal: Annals of Internal Medicine (2013)

Letters18 June 2013Illness in Returned TravelersPaul D. Blanc, MD, MSPHPaul D. Blanc, MD, MSPHFrom University of California, San Francisco, San Francisco, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-12-201306180-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Leder and colleagues’ surveillance report (1) on illnesses among persons returning from foreign travel provides rich data. The authors, however, could have been more circumspect in the interpretation of their observations and more catholic in their categorization of travel for work purposes. As Table 4 notes, 7 among 28 deaths (25%) occurred among “business” travelers, even though this category as defined accounted for only 13.6% of 42 173 cases (Table 1), reported in Figure 3 as n = 5728. On the basis of these data, the authors suggest “that employers consider their potential liability if a consultation before travel ...References1. Leder K, Torresi J, Libman MD, Cramer JP, Castelli F, Schlagenhauf P, et al; GeoSentinel Surveillance Network. GeoSentinel surveillance of illness in returned travelers, 2007–2011. Ann Intern Med. 2013;158:456-68. [PMID: 23552375] LinkGoogle Scholar2. Bailar JC, Ederer F. Significance factors for the ratio of a Poisson variable to its expectation. Biometrics. 1964;20:639-43. CrossrefGoogle Scholar Author, Article, and Disclosure InformationAuthors: Paul D. Blanc, MD, MSPHAffiliations: From University of California, San Francisco, San Francisco, California.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGeoSentinel Surveillance of Illness in Returned Travelers, 2007–2011 Karin Leder , Joseph Torresi , Michael D. Libman , Jakob P. Cramer , Francesco Castelli , Patricia Schlagenhauf , Annelies Wilder-Smith , Mary E. Wilson , Jay S. Keystone , Eli Schwartz , Elizabeth D. Barnett , Frank von Sonnenburg , John S. Brownstein , Allen C. Cheng , Mark J. Sotir , Douglas H. Esposito , and David O. Freedman , for the GeoSentinel Surveillance Network* Illness in Returned Travelers Karin Leder , Michael D. Libman , and Mark J. Sotir Metrics 18 June 2013Volume 158, Issue 12Page: 924KeywordsConflicts of interestMotivation ePublished: 18 June 2013 Issue Published: 18 June 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sepsis Due to<i>Escherichia coli</i>in Neonates with Galactosemia
Authors: Harvey L. Levy, Stephen J. Sepe, Vivian E. Shih, Gordon F. Vawter, Jerome O. Klein
Journal: New England Journal of Medicine (1977)

Galactosemia, an inborn error of galactose metabolism, is characterized by jaundice, weight loss, lethargy and vomiting in the neonate and by cataracts, mental retardation and cirrhosis in later infancy or early childhood.1 However, the high frequency of neonatal death from sepsis among infants with galactosemia has not been widely recognized, though it has been mentioned in several reports.2 3 4 5 As a result of routine newborn screening for galactosemia, conducted in Massachusetts for approximately 12 years (from 1964 to 1965 and 1966 to the present), eight infants with "classic" galactosemia due to galactose-1-phosphate uridyl transferase (transferase) deficiency have been identified among over . . .
Abstract 4601: The role of nicotine-induced oxidative stress in oral cancer cells
Authors: Xiaofei Tang, Yanhua Zhang, Min Zhang
Journal: Cancer Research (2012)

Abstract Objective To investigate the role of nicotine-induced oxidative stress in SCC15 oral cancer cells. Methods The growth, apoptosis, ROS level, Prx1 expression and NF-αb DNA binding activity were detected in SCC15 oral cancer cell using MTT assay, RT-PCR, Western blotting, flow cytometry, ELISA. Results The ROS level was elevated in SCC15 cells treated with nicotine for 24h at different concentrations (0.1μM, 1μM, 10μM). Cell growth was induced by nicotine for 24h, 48h at different concentrations. Few SCC15 cells were induced apoptotic cell death treated with nicotine for 24h, there was no obvious changes in cell apoptosis for 48h, 72h, compared with control. Prx1 mRNA and protein expression were up-regulation treated with nicotine. NF-αb DNA binding activity was increased treated with nicotine for 24h, 48h, 72h. Conclusion Nicotine induced oxidative stress and cell proliferation, which maybe regulated by Prx1/NF-αb axis in oral cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4601. doi:1538-7445.AM2012-4601
Differential Gene Expression in Normal Human Mammary Epithelial Cells Treated with Malathion Monitored by DNA Microarrays
Authors: Maureen R. Gwinn, Diana L. Whipkey, Lora B. Tennant, Ainsley Weston
Journal: Environmental Health Perspectives (2005)

Organophosphate pesticides are a major source of occupational exposure in the United States. Moreover, malathion has been sprayed over major urban populations in an effort to control mosquitoes carrying West Nile virus. Previous research, reviewed by the U.S. Environmental Protection Agency, on the genotoxicity and carcinogenicity of malathion has been inconclusive, although malathion is a known endocrine disruptor. Here, interindividual variations and commonality of gene expression signatures have been studied in normal human mammary epithelial cells from four women undergoing reduction mammoplasty. The cell strains were obtained from the discarded tissues through the Cooperative Human Tissue Network (sponsors: National Cancer Institute and National Disease Research Interchange). Interindividual variation of gene expression patterns in response to malathion was observed in various clustering patterns for the four cell strains. Further clustering identified three genes with increased expression after treatment in all four cell strains. These genes were two aldo-keto reductases (AKR1C1 and AKR1C2) and an estrogen-responsive gene (EBBP). Decreased expression of six RNA species was seen at various time points in all cell strains analyzed: plasminogen activator (PLAT), centromere protein F (CPF), replication factor C (RFC3), thymidylate synthetase (TYMS), a putative mitotic checkpoint kinase (BUB1), and a gene of unknown function (GenBank accession no. AI859865). Expression changes in all these genes, detected by DNA microarrays, have been verified by real-time polymerase chain reaction. Differential changes in expression of these genes may yield biomarkers that provide insight into interindividual variation in malathion toxicity.
Study of London taxi drivers wins Ig Nobel prize
Authors: J. Lenzer
Journal: BMJ (2003)

Paper airplanes, Nobel laureates, opera singers, Miss Sweetie Poo, and the Stud Muffins of Science all graced the stage of Harvard University's Sanders Theater for the annual Ig Nobel prize ceremony last week. Cheers, hoots, and shouts of disbelief greeted the winners.

The Ig Nobel prizes, awarded to scientists whose work “first makes people laugh—then makes them think,” are given to mostly honoured, sometimes insulted, scientists who fly themselves to Boston from around the world to receive their “Ig” and explain their work. Scientists from four continents were awarded prizes in 10 categories this year.

For her work showing that the brains of London taxi drivers were more highly developed than the brains of non-taxi drivers, Eleanor Maguire won the 2003 Ig Nobel medicine prize. Dr Maguire, senior …
Angiotensin converting enzyme and kininase-II-like activities in cultured valvular interstitial cells of the rat heart
Authors: L. C Katwa, A. Ratajska, J. P. Cleutjens, Y. Sun, G. Zhou, S. J. Lee, K. T Weber
Journal: Cardiovascular Research (1995)

Objective: The function of angiotensin converting enzyme (ACE) at cell sites of high collagen turnover, such as heart valves, is uncertain. The aim of this study was to assess ACE and kininase-II-like activities and collagen turnover in cultured valvular interstitial cells of the adult rat heart. Methods: The valvular interstitial cell phenotype was determined by immunolabelling (rhodamine phalloidin, desmin, and Griffonia simplicifolia lectin), and the presence of ACE mRNA and protein was confirmed by reverse transcriptase-polymerase chain reaction analysis, ACE monoclonal antibody and in vitro autoradiography, respectively. ACE and kininase-II-like activities in valvular interstitial cells were analysed by high performance liquid chromatography. Angiotensin II (AT1) and bradykinin receptors in valvular interstitial cell membranes were examined by western immunoblotting and binding assay. Type I collagen and collagenase in valvular interstitial cell culture media were determined by elisa and zymography, respectively. Type I collagen mRNA expression in cultured valvular interstitial cells was determined by northern blot analysis and in situ hybridisation. Results: In intact valvular interstitial cells or their cell membrane we found: (1) actin microfilaments, but not desmin or lectin labelling; (2) ACE mRNA expression and binding activity; (3) conversion of angiotensin I to angiotensin II, which was completely inhibited by 50 μM lisinopril, while kininase-II-like activity exceeded ACE activity and was not inhibited by lisinopril; (4) AT1 and bradykinin receptors in valvular interstitial cell membrane preparations; (5) type I collagen mRNA expression and collagenase activity; and (6) angiotensin II induced increase in type I collagen synthesis and mRNA expression. Conclusions: Cultured valvular interstitial cells represent a non-endothelial, non-smooth-muscle cell type that expresses mRNA for ACE and type I collagen. ACE and kininase-II-like activities in valvular interstitial cells may be involved in the regulation of peptides that influence collagen turnover. Angiotensin II stimulates type I collagen synthesis and mRNA expression in these cells.
Bone metabolism in rheumatoid arthritis compared with postmenopausal osteoporosis.
Authors: R M van Soesbergen, P Lips, A van den Ende, J K van der Korst
Journal: Annals of the Rheumatic Diseases (1986)

Calcium and bone metabolism in 29 rheumatoid arthritis (RA) patients were compared with those in 27 postmenopausal osteoporotic patients. Signs of vitamin D deficiency were found in 20 RA patients, including 12 who took recommended amounts of vitamin D in their diets and were exposed to sufficient sunlight, and in none of the osteoporotic patients. There were no signs of malabsorption. In six out of 15 patients we found increased liver enzyme activity, which may have a role in vitamin D metabolism. We propose the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on vitamin D metabolism in the liver as a possible explanation.
Simian Immunodeficiency Virus in People
Authors: Max Essex
Journal: New England Journal of Medicine (1994)

The simian immunodeficiency viruses (SIVs) were initially identified on the basis of antibody cross-reactivity with human immunodeficiency virus type 1 (HIV-1)1. Serum samples from macaque monkeys from Asia with AIDS-like diseases were found to have antibodies that reacted with HIV-1 antigens. The reactivity was most pronounced for the viral core antigens and less evident for the type-specific viral envelope antigens. HIV type 2 (HIV-2) was subsequently identified in West African prostitutes on the basis of a serologic antibody profile that more closely resembled the profile of macaque SIV than that of HIV-12.Seroepidemiologic studies reveal that wild African . . .
Abstract P5-10-11: Ongoing Evaluation of Capecitabine-Based Therapy in Early Breast Cancer (EBC)
Authors: C Poole, C Barrios, J O'Shaughnessy, M Martin, V. Möbus
Journal: Cancer Research (2010)

Abstract Background: Capecitabine (C) is an established agent in MBC &amp; is being evaluated in anthracycline/taxane-based adjuvant (adj) &amp; neoadjuvant (neoadj) regimens. Methods: We summarise available data for C from randomised phase III studies in EBC. Results: Significant efficacy benefits were reported with two C-based regimens in EBC: recurrence-free survival (RFS) was significantly improved when C was added to an adj regimen in the FinXX trial (3-year RFS: 93% vs 89% control; HR 0.66 [95% CI: 0.47-0.94]; p=0.02) [Lancet Oncol 2009;10:1145-51]. Pathological complete response (pCR) was significantly higher when C was integrated into a standard neoadj regimen in the ABCSG-24 study (24.3% vs 16.0% control; p=0.02) [ECCO-ESMO 2009; Abst 4BA]. Two studies were negative: one adj [Muss et al. NEJM 2009;360:2055-65] &amp; one neoadj [GeparQuattro JCO 2010;2024-31]. D=docetaxel; Cyc=cyclophosphamide; E=epirubicin; F=5-FU; A=doxorubicin; P=paclitaxel; bev=bevacizumab; G=gemcitabine; M=methotrexate; DFS=disease-free survival; EFS=event-free survival Safety data are available from 3 other adj studies: in the GEICAM trial, ED→C was generally well tolerated and associated with significantly better hair recovery than control (incomplete hair recovery: 28% ECyc→D vs 11% ED→C; p=0.0004); in the GAIN study, haematological toxicities were more common in the E→P→Cyc arm &amp; discontinuations more frequent with ECyc→CP; in the ICE study in pts aged &amp;gt;65 yrs, a low incidence of grade 3/4 AEs was reported with C &amp; significantly higher global QoL scores were attained with C vs control (week 20, p=0.008). Several phase III trials are ongoing (table): US Oncology is conducting a study in high-risk EBC, which will report efficacy data shortly; CIBOMA collaborative group is conducting a trial of C maintenance therapy after adj anthracycline/taxane in triple-negative EBC; the TACT2 study has a 2x2 factorial design in resected/operable EBC; safety data are expected from both studies: MINDACT is an EORTC/collaborative group study in node-negative EBC and compares a 70-gene signature with traditional methods of risk evaluation; pts with high-risk disease receive anthracyclines or CD. Conclusions: The ongoing evaluation of C in EBC encompasses &amp;gt;20,000 pts. Following initial positive data for C in EBC, further results of these trials are eagerly awaited to define the clinical utility of C-based therapy in this setting. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P5-10-11.
HOW IS THE EARLY DIAGNOSIS OF PULMONARY TUBERCULOSIS TO BE MADE?
Authors: A. Garvie
Journal: BMJ (1917)

C m lmJoU 741 for them free of charge under those Acts; h-lowever, such cases can be multiplied indefinitely wlhere people consider it more desirable to employ a handy-woman wlho remains in residence during the lying-in, period, and washes and liouselieeps for the household, wllile the unremunerated disiensary doctor is compelled to take over the work, and also the opprobritum of the untrained midwives' too- frequently-fatal mistakes.Where in the bill are we empowered to expel untrained women from the charge of a " Poor Law emnergency case " and substitute our trained lnurse?No suclh provision is made.Is the Local Government Board prepared to
Infarct size reduction by propranolol before and after coronary ligation in dogs.
Authors: M M Rasmussen, K A Reimer, R A Kloner, R B Jennings
Journal: Circulation (1977)

Coronary occlusion in the dog results in irreversible myocardial cell injury which develops first in subendocardial areas of severe ischemica and subsequently spreads into mid and subepicardial areas of moderate ischemia. The effect of propranolol on this progression of ischemic injury was evaluated. Three groups of dogs were studied: 1) untreated, 2) treated with propranolol before and throughout coronary ligation, and 3) treated with propranolol beginning three hours after ligation. Dogs were sacrificed 24 hours after coronary ligation and necrosis was quantitated from histologic sections of transmural slices through the posterior papillary muscle. Propranolol reduced infarct size by preventing necrosis in peripheral (subepicardial) areas of moderately ischemic myocardium. Pretreatment with propranolol reduced necrosis from 85 +/- 3% (untreated) to 52 +/- 4% (P less than 0.05). Delayed propranolol therapy was about half as effective as pre-treatment and reduced necrosis to 71 +/- 3% (P less than 0.05). Propranolol also limited microvascular injury so that perfusion defects, detected with the dye thioflavin S, were smaller in treated dogs.
DMAA as a Dietary Ingredient—Reply
Authors: Pieter A. Cohen
Journal: JAMA Internal Medicine (2013)

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797-2 Increased Tissue Factor at Sites of Thrombosis in an Atherosclerotic Animal Model
Authors: Michael T. Johnstone, Jaime E. Murillo, Richard Dalfen, Tom Daly, Aruna Pawashe, William Konigsberg, Michael Ezekowitz, William Quist, Tom Aretz, James E. Muller, Geoffrey H. Tofler, Victor Gurewich
Journal: Journal of the American College of Cardiology (1995)
Foot Infections in Swimming Baths
Authors: J. C. Gentles, E. G. V. Evans
Journal: BMJ (1973)

A 10% random sample of all bathers at a public swimming bath were examined for tinea pedis and verruca.The overall incidence of tinea pedis was 8.5% and of verruca 4.8%. The incidence of tinea pedis in 205 male adults was 21.5%, in 288 boys 6.3%, in 60 adult females 3.3%, and in 220 girls 0.9%. The incidence of verruca in juveniles ranged from 4.2% in boys to 10.5% in girls.It was clear that both infections spread within the baths, and since a relatively small proportion of users admitted to taking precautions to avoid contracting or developing infections it seems advisable that more publicity about recommendations on foot care should be provided.