tbuckley/cabot-search huggingface dataset:
The association between serum levels of Th cytokines and rhinoconjunctivitis caused by methyltetrahydrophthalic anhydride
Authors: K. Yokot, K. Yamaguchi, T. Takeshita, K. Morimoto
Journal: Allergy (1998)

Background There are few epidemiologic studies on the association between serum levels of T helper (Th) cytokines and allergic symptoms caused by sensitizing agents. Methods A population of 147 workers from two condenser plants using epoxy resin with methyltetrahydrophthalic anhydride (MTHPA) underwent a questionnaire survey and serologic investigations. Total and MTHPA‐specific IgE levels were measured by the Pharmacia CAP System, and serum levels of interleukin (IL)‐4, IL‐13, and interferon‐gamma (IFN‐γ) by enzyme immunoassay. Results A significant association was found between work‐related eye and nasal symptoms and a range of atopic characteristics, including the frequency of positive specific IgE, specific and total IgE levels, and IL‐4 levels. A positive correlation was observed between levels of IL‐4 and IL‐13 (r=0.42). Furthermore, multiple logistic analysis revealed significant contributions of specific IgE and I H3 to the work‐related symptoms. A similar but nonsignificant association was also found for IL‐4 (P=0.07). On the other hand, a multiple regression model with specific IgE levels as a dependent variable showed a significant association with total IgE, but not with IL‐4, IL‐13, and IFN‐γ. Conclusions These results suggest that work‐related eye and nasal symptoms are closely related to specific IgE antibodies, and that allergic responses, mediated by IgE, to MTHPA may lead to a shift in the balance between Thl and Th2 cells.
The Canadian “National Program for hemophilia mutation testing” database: A ten‐year review
Authors: Rydz Natalia, Leggo Jayne, Tinlin Shawn, James Paula, Lillicrap David
Journal: American Journal of Hematology (2013)

A reference genotyping laboratory was established in 2000 at Queen's University, Kingston, to provide genetic testing for Hemophilia A (HA) and B (HB) and create a Canadian mutation database. Canadian hemophilia treatment centers and genetics clinics provided DNA and clinical information from November 2000 to March 2011. The factor VIII (F8) gene was analyzed in 1,177 patients (47% of HA population) and 787 female family members and the factor IX (F9) gene in 267 patients (47% of HB population) and 123 female family members, using Southern Blot, PCR, conformation sensitive gel electrophoresis, and/or direct sequencing. The mutation detection rates for HA and HB were 91% and 94%, respectively. 380 different F8 mutations were identified: inversions of intron 22 and intron 1, 229 missense, 45 nonsense, eight deletions, 70 frameshifts, 25 splice site, and one compound mutation with a splice site and intron 1 inversion. Of these mutations, 228 were novel to the Hemophilia A Database (HADB, http://hadb.org.uk/ ). A total 125 different F9 mutations were identified: 80 missense, 12 frameshift, 12 splice site, nine nonsense and seven promoter mutations, three large deletions, and two compound mutations with both missense and nonsense changes. Of these mutations, 36 were novel to the International Haemophilia B Mutation database ( http://www.kcl.ac.uk/ip/petergreen/haemBdatabase.html ). The Canadian F8 and F9 mutation database reflects the allelic heterogeneity of HA and HB, and is similar to previously described populations. This report represents the largest and longest duration experience of a national hemophilia genotyping program documented, to date. Am. J. Hematol. 88:1030–1034, 2013. © 2013 Wiley Periodicals, Inc.
499 The impact of sustained virological response (SVR) on health-related quality of life (HRQL) in patients with chronic hepatitis C (CHC) and persistently normal ALT levels (PNALT) treated with peginterferon alfa-2A (PEGASYS®) and ribavirin (COPEGUS®)
Authors: C. O'Brien, N. Wintfeld, K.K. Patel, S. Zeuzem, M.L. Shiffman, M. Diago, A. Tran, P. Pockros, J. Green
Journal: Journal of Hepatology (2004)
BONY BRIDGING IN TUBERCULOSIS OF THE SPINE
Authors: ROBERT B. COFIELD
Journal: JAMA (1922)

Bony bridging of the vertebrae in spondylitis has been considered, since the advent of roentgenology, a distinct evidence of the nontuberculous nature of the disease. Hypertrophic changes and bony ankylosis have long been known to occur subsequent to mixed infections resulting from incision and drainage of cold abscesses produced by tuberculous infection, but the fact that such bony changes occur when no drainage has been established has been considered sufficient evidence to rule out tuberculosis, and has been generally accepted as pathognomonic of certain other types of infection. Tuberculous spondylitis has been frequently and necessarily confused with such conditions as spondylitis deformans, traumatic spondylitis and other vertebral affections in their incipience; but as soon as hypertrophic bony changes were manifest, the possibility of the lesion being tuberculous was dismissed and the condition has generally been treated as a nontuberculous disease. The fallacy of this deduction was first brought forcibly to
Fortnightly review: Oral cancer
Authors: J. M Zakrzewska
Journal: BMJ (1999)

The survival of patients with oral cancer remains poor despite recent surgical advances.About 30-40% of patients with intra-oral cancers will survive five years; the short survival time is caused, largely, by late detection. 1Public awareness of oral cancer as compared with other cancers is low and this contributes to delays in diagnosis. 2However, the mouth can be examined by healthcare professionals with much greater ease and accuracy than many other parts of the body.All healthcare workers need to be aware that a patient with an ulcer or white patch that persists beyond three weeks should be referred for further evaluation to an oral physician or to an oral and maxillofacial surgeon.Tobacco use is a major cause of oral cancer, and doctors and other health professionals can contribute to primary prevention by making patients aware that tobacco, in all forms, predisposes them to oral cancer. MethodsThe majority of references in this article were obtained from a personal collection built during 10 years of work in this subject and during a study of screening for oral cancer.A Medline search of articles published between 1966 and 1998 using the terms ''mouth'' and ''neoplasms'' yielded 20 664 articles.Adding the keywords ''systematic'' and ''review'' did not identify any systematic reviews.The Cochrane database does not list any protocols or completed systematic reviews of randomised controlled trials of head and neck surgery. 3 Searching the Cochrane Controlled Trials Register identified 11 randomised controlled trials, mainly on the use of chemotherapy.The American College of Physicians Journal Club and Evidence-Based Medicine database (1991-1997) lists no articles relating to mouth neoplasms.
The 2', 3'-cyclic AMP 3'-phosphohydrolase in normal and psoriatic epidermis
Authors: MICHAEL MEZEI, DENIS R.S. HOWELL
Journal: British Journal of Dermatology (1979)

The activity of the enzyme 2', 3'-cyclic AMP 3'-phosphohydrolase is significantly greater in the 'involved' psoriatic skin than in the 'uninvolved' psoriatic skin or in skin samples taken from persons having clinically normal skin. Although the physiological function of this enzyme is not established, it is possible that, besides being associated with myelin, it may also play some role in cell proliferation and maturation, probably at the membrane level.
Chest wall tumour following iodized talc pleurodesis
Authors: J. W. Jackson, M. H. Bennett
Journal: Thorax (1973)

<b>Jackson, J. W., and Bennett, M. H. (1973).</b><i>Thorax</i>, <b>28</b>, 788-793. <b>Chest wall tumour following iodized talc pleurodesis.</b> A man of 37 had an iodized talc pleurodesis carried out for recurrent spontaneous pneumothorax. There was no history of industrial exposure to asbestos. Two years later he presented with pain in the right chest and radiographs at that time showed some localized pleural thickening at the site of the thoracoscopy cannulation for introduction of talc. A provisional diagnosis of talc granuloma, chemical abscess or tumour was made and exploratory thoracotomy revealed a tumour involving the chest wall, lung, and pleura which, on histological examination, showed adenocarcinoma of varying degrees of differentiation and in some parts also presenting a more squamoid appearance. Numerous doubly refractile talc particles were intimately associated with the tumour and fibrous tissue. Shortly after excision the patient developed evidence of systemic dissemination of the disease and died four months later. The possibility of this tumour being induced by the talc is discussed. A brief review is made of the various forms of talc used in surgery over the past 40 years and attention is drawn to the significance of the proportion of asbestos mineral which is present in talc as mined in various parts of the world. We do not consider that this is a case of mesothelioma of the pleura.
Consensus Proposals for a Unified System of Nomenclature of Hepatitis C Virus Genotypes *
Authors: Peter Simmonds, Jens Bukh, Christophe Combet, Gilbert Deléage, Nobuyuki Enomoto, Stephen Feinstone, Phillippe Halfon, Geneviève Inchauspé, Carla Kuiken, Geert Maertens, Masashi Mizokami, Donald G. Murphy, Hiroaki Okamoto, Jean-Michel Pawlotsky, François Penin, Erwin Sablon, Tadasu Shin-I, Lieven J. Stuyver, Heinz-Jürgen Thiel, Sergei Viazov, Amy J. Weiner, Anders Widell
Journal: Hepatology (2005)

Abstract International standardization and coordination of the nomenclature of variants of hepatitis C virus (HCV) is increasingly needed as more is discovered about the scale of HCV-related liver disease and important biological and antigenic differences that exist between variants. A group of scientists expert in the field of HCV genetic variability, and those involved in development of HCV sequence databases, the Hepatitis Virus Database (Japan), euHCVdb (France), and Los Alamos (United States), met to re-examine the status of HCV genotype nomenclature, resolve conflicting genotype or subtype names among described variants of HCV, and draw up revised criteria for the assignment of new genotypes as they are discovered in the future. A comprehensive listing of all currently classified variants of HCV incorporates a number of agreed genotype and subtype name reassignments to create consistency in nomenclature. The paper also contains consensus proposals for the classification of new variants into genotypes and subtypes, which recognizes and incorporates new knowledge of HCV genetic diversity and epidemiology. A proposal was made that HCV variants be classified into 6 genotypes (representing the 6 genetic groups defined by phylogenetic analysis). Subtype name assignment will be either confirmed or provisional, depending on the availability of complete or partial nucleotide sequence data, or remain unassigned where fewer than 3 examples of a new subtype have been described. In conclusion , these proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future. (Hepatology 2005.)
Miller’s Anesthesia
Authors: Martin H. Dauber
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advisory on Medical Telemetry System Interference Problem
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
Authors: Kevin Wei, Stephanie M Piecewicz, Lisa M McGinnis, Cullen M Taniguchi, Stanley J Wiegand, Keith Anderson, Carol W-M Chan, Kimberly X Mulligan, David Kuo, Jenny Yuan, Mario Vallon, Lori C Morton, Etienne Lefai, M Celeste Simon, Jacquelyn J Maher, Gilles Mithieux, Fabienne Rajas, Justin P Annes, Owen P McGuinness, Gavin Thurston, Amato J Giaccia, Calvin J Kuo
Journal: Nature Medicine (2013)
Mitochondrial DNA Mutations and Apoptosis in Mammalian Aging
Authors: Gregory C. Kujoth, Christiaan Leeuwenburgh, Tomas A. Prolla
Journal: Cancer Research (2006)

Abstract Mutations in mitochondrial DNA (mtDNA) accumulate during aging, but their significance to longevity and age-associated disease has been uncertain. Recently, in support of the hypothesis that mtDNA integrity is important, we have shown that age-associated diseases arise more rapidly in mice where mtDNA mutations and increased levels of apoptosis occur at higher rates than normal due to expression of an error-prone mtDNA polymerase. Further studies in this model may provide deeper insights into the relationship between mitochondria, aging, and susceptibility to age-associated diseases, such as cancer. (Cancer Res 2006; 66(15): 7386-9)
THE APPLICATION OF THE ROENTGEN RAYS TO MEDICAL DIAGNOSIS.
Authors: CHARLES LESTER LEONARD
Journal: JAMA (1897)

The application of the Roentgen rays to medical science has already given to surgery a method of diagnosis the precision of which makes it of the greatest value; this value lies in the absolute pictures which we are able to secure by its means, and loses its preeminence as soon as we are compelled to substitute for the absolute picture in black and white, mental pictures which always involve the personal equation of the observer. It is worse than useless to suppose that any new method of forming mental pictures, no matter how startling or radical, can equal in accuracy or approach in value those which the science of medical diagnosis has already taught us to form with well-nigh infallible precision. It would be supererogation on the part of anyone to think that the mental pictures which he might form by the use of the Roentgen rays could replace or
Value of FDG PET Imaging in the Management of Patients With Thyroid, Neuroendocrine, and Neural Crest Tumors
Authors: Daniel R. Scanga, William H. Martin, Dominique Delbeke
Journal: Clinical Nuclear Medicine (2004)

The purpose of this study was to evaluate the value and impact on management of FDG PET imaging in patients with biopsy-proved neuroendocrine and neural crest tumors, as well as thyroid carcinoma of various types.This is a retrospective review of imaging and clinical data of 60 consecutive patients presenting for evaluation of suspected recurrence who underwent FDG PET imaging between August 1993 and February 2002. All patients were referred for PET because of equivocal findings on conventional evaluation (most often increasing tumor markers and negative conventional workup) or for restaging. The final diagnosis was established with pathology (n = 19) or at least 6 months of follow-up (n = 41). The FDG images were acquired 1 hour after the intravenous administration of 10 mCi FDG with 1 of 2 dedicated PET tomographs (Siemens ECAT 933, CTI, Knoxville, TN; and GE Advance, General Electric Medical Systems, Milwaukee, WI).Thirty-four patients had recurrent disease and 26 had no evidence of recurrence. FDG PET imaging revealed at least as many focal abnormalities as concurrent CT, magnetic resonance, or other nuclear imaging modalities in 46 of 60 patients (77%). There were 17 patients (28%) in whom FDG PET found abnormalities not seen with other modalities. In the small group (n = 18) of cases of carcinoid, pheochromocytoma, Merkel cell tumor, and neuroblastoma, all cases were true positive (T+) or true negative (T-). In the group of 42 cases of thyroid carcinoma, the sensitivity was 67%. There were 16 T+, 18 T-, and 8 false-negative (F-) cases. Six F- cases presented with increasing thyroglobulin levels and negative whole-body I-131 scans. Four of these 6 F- cases were proved by surgery, 1 by a positive post I-131 therapy scan, and 1 by normalization of thyroglobulin levels after I-131 therapy. Two of the 8 F- PET cases had a positive I-131 scan. FDG PET imaging had an impact on the management of 13 of 60 of these patients (22%) by demonstrating extensive metastases and cancelling surgery (n = 2), and by detecting recurrence and guiding surgery (n = 5) or radiation therapy (n = 6).FDG PET is helpful in the evaluation of thyroid, neuroendocrine, and neural crest tumors. Although the sensitivity was only 76%, there were no false-positive findings, and FDG PET findings changed the management of 22% of the patients.
Blood flow and perfusion in acute haemorrhagic pancreatitis in the dog.
Authors: J G Studley, R T Mathie, M I Gibbons, L H Blumgart
Journal: Gut (1986)

Experimental evidence suggests that in acute haemorrhagic pancreatitis in the dog the percentage of the cardiac output distributed to the pancreas falls. Histological evidence indicates arteriovenous shunt flow, but this has not been confirmed by flow measurements. It has recently been reported that in experimental preparations in which pancreatic blood flow is measured through the superior pancreaticoduodenal artery after ligation of other (accessory) vessels, perfusion is reduced in distal regions of the gland. There are no data regarding regional perfusion measurements in acute pancreatitis or the effect of ligating accessory vessels. This study therefore evaluates blood flow and regional perfusion in haemorrhagic pancreatitis in various preparations of the canine pancreas. Perfusion was assessed by measuring the clearance of Krypton-85 after injection into the arterial blood supply of the pancreas. Arterial blood flow was measured by the electromagnetic flow technique. The results show that perfusion in different regions of the gland is similar both before and during disease. If accessory vessels are ligated, however, only perfusion in the head of the gland is maintained. No arteriovenous shunt flow was shown. The percentage of the cardiac output being distributed to the gland did not change in any of the experiments; this contradiction to previous reports may arise from the effective control of acid base balance in this study.
Infant feeding practices.
Authors: P D Manuel, J A Walker-Smith
Journal: BMJ (1978)

report by Raz et al,' on the clinical occurrence of stress incontinence in three women after medication with diphenylhydantoin for grand mal epilepsy.Using in-vitro techniques of measurement of the urethral pressure profile by the Brown and Wickham method on the urethra of the female dog, they proceeded to show a fall in the urethral pressure after administration of intravenous diphenylhydan- toin.They gave intravenous noradrenaline, which produced a rise in urethral pressure but which was subsequently cancelled when diphenylhydantoin was administered.The suggested mode of action of diphenylhydantoin was to prevent the effective depolarisation of muscle cells, hence blocking the ax-adrenergic effect of noradrenaline.I would like to point out one error in this article: the dose of propantheline was in- correctly stated as 15-200 mg three times a day, whereas it should have read 15-20 mg three times a day.
Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy
Authors: Kathleen C. Barnes, Linda R. Freidhoff, Renate Nickel, Yen-Feng Chiu, Suh-Hang Juo, Nobuyuki Hizawa, Raana P. Naidu, Eva Ehrlich, David L. Duffy, Carsten Schou, Paul N. Levett, David G. Marsh, Terri H. Beaty
Journal: Journal of Allergy and Clinical Immunology (1999)

<h2>Abstract</h2> <b>Background:</b> Asthma is a complex disease characterized by a high prevalence of allergic diathesis and the almost ubiquitous presence of upper airway disease (eg, rhinitis). Previously, we observed linkage of asthma among Afro-Caribbean families to markers in chromosome 12q, which contains a number of genes encoding for products closely related to allergic airway inflammation and disease. <b>Objective:</b> To identify susceptibility loci in chromosome 12q contributing to the genetics of upper and lower airway diseases and to expand the region to include genes encoding IFN-γ (<i>IFNG</i> ) and one of the signal transducers and activators of transcription (<i>STAT6</i> ), we conducted further linkage studies among 33 multiplex families. <b>Methods:</b> We characterized 528 subjects from Barbados for asthma; 82% were characterized for allergic rhinitis. Two-point and multipoint linkage analysis of 22 microsatellite markers (spanning ~79 centimorgan) was performed. <b>Results:</b> Affected sib-pair analysis revealed significant evidence for linkage to asthma over approximately 30 cM (<i>P</i> < .05 to .002), with the best evidence for linkage at a CA repeat polymorphism in the first intron of <i>IFNG</i> in 12q21.1 (<i>P</i> = .002). Evidence of linkage to allergic rhinitis was observed in the same region (<i>D12S313</i> , <i>P</i> = 0.006, and <i>IFNGCA</i> , <i>P</i> = .01, respectively). Multipoint linkage analysis also provided evidence for linkage to asthma, with the best nonparametric linkage analysis score at <i>D12S326</i> (nonparametric linkage score=3.8, <i>P</i> = .0008). Modest evidence for linkage to allergic rhinitis was observed next to <i>D12S326</i> at <i>D12S1052</i> (<i>P</i> = .036). <b>Conclusions:</b> Our findings suggest that (1) one or more loci in the chromosome 12q13.12–q23.3 region are contributing to the expression of the clinical phenotype asthma and the strongest evidence for linkage is in a region near the gene encoding <i>IFNG</i> and (2) a susceptibility locus for both asthma and allergic rhinitis maps to this region. (J Allergy Clin Immunol 1999;104:485-91.)