<i>N</i>-of-1 (Single-Patient) Trials for Statin-Related Myalgia
Authors: Oladimeji Akinboro, Linda Williams, Daniel Pomerantz
Journal: Annals of Internal Medicine (2014)

Letters7 October 2014N-of-1 (Single-Patient) Trials for Statin-Related MyalgiaOladimeji Akinboro, MD, MPH, Linda Williams, MD, and Daniel Pomerantz, MD, MPHOladimeji Akinboro, MD, MPHFrom Montefiore New Rochelle Hospital, New Rochelle, New York., Linda Williams, MDFrom Montefiore New Rochelle Hospital, New Rochelle, New York., and Daniel Pomerantz, MD, MPHFrom Montefiore New Rochelle Hospital, New Rochelle, New York.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In Joy and colleagues' article (1), placebo and the intervention were each administered for 3 weeks in randomized sequences with intervening 3-week washout periods. However, prior studies suggest that statin-induced myalgia begins within weeks to months of starting therapy, with a mean period of 6 months reported in a review by Hansen and associates (2, 3). In their review, the mean period for resolution of symptoms was 2 months. Therefore, the question that arises is whether the 3-week treatment and intervening washout periods used in this study were long enough for the study participants to develop and ...References1. Joy TR, Monjed A, Zou GY, Hegele RA, McDonald CG, Mahon JL. N-of-1 (single-patient) trials for statin-related myalgia. Ann Intern Med. 2014;160:301-10. [PMID: 24737272] doi:10.7326/M13-1921 LinkGoogle Scholar2. Hansen KE, Hildebrand JP, Ferguson EE, Stein JH. Outcomes in 45 patients with statin-associated myopathy. Arch Intern Med. 2005;165:2671-6. [PMID: 16344427] CrossrefMedlineGoogle Scholar3. Bruckert E, Hayem G, Dejager S, Yau C, Bégaud B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients—the PRIMO study. Cardiovasc Drugs Ther. 2005;19:403-14. [PMID: 16453090] CrossrefMedlineGoogle Scholar4. Lillie EO, Patay B, Diamant J, Issell B, Topol EJ, Schork NJ. The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Per Med. 2011;8:161-173. [PMID: 21695041] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Montefiore New Rochelle Hospital, New Rochelle, New York.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0293. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoN-of-1 (Single-Patient) Trials for Statin-Related Myalgia Tisha R. Joy , Alaa Monjed , Guang Yong Zou , Robert A. Hegele , Charlotte G. McDonald , and Jeffrey L. Mahon N-of-1 (Single-Patient) Trials for Statin-Related Myalgia Tisha R. Joy , Guang Yong Zou , and Jeffrey L. Mahon N-of-1 (Single-Patient) Trials for Statin-Related Myalgia Tisha R. Joy , Guang Yong Zou , and Jeffrey L. Mahon Metrics Cited ByUsing Knowledge Graph for Analysis of Neglected Influencing Factors of Statin-Induced Myopathy 7 October 2014Volume 161, Issue 7Page: 531KeywordsConflicts of interestDisclosureForecastingMyalgiaStatins ePublished: 7 October 2014 Issue Published: 7 October 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...