Cyclosporin in Wegener Granulomatosis
Authors: FRANZ GREMMEL
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 March 1988Cyclosporin in Wegener GranulomatosisFRANZ GREMMEL, M.D., WILFRED DRUML, M.D., PAUL SCHMIDT, M.D., WOLFGANG GRANINGER, M.D., PH.D.FRANZ GREMMEL, M.D.Search for more papers by this author, WILFRED DRUML, M.D.Search for more papers by this author, PAUL SCHMIDT, M.D.Search for more papers by this author, WOLFGANG GRANINGER, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-3-491_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The combination of cyclophosphamide and prednisolone is the treatment of choice in Wegener granulomatosis (1). Despite the high remission rate achieved, 7% of the patients (mainly those with rapidly progressive disease) will not respond, and cytotoxic therapy carries a considerable risk, with several patients in remission having died from opportunistic infections (1, 2). We treated two patients who had Wegener granulomatosis (one with multiorgan failure unresponsive to cyyclophosphamide and the other with renal failure) with cyclosporin A. This treatment resulted in a sustained remission and recovery of renal function.A 45-year-old man was admitted to the intensive...References1. FAUCIHAYNESKATZWOLFF ABPS. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98:76-85. LinkGoogle Scholar2. KUROSSDABINKJELLSTRAND STC. Wegener's granulomatoisis with severe renal failure: clinical course and results of dialysis and transplantation. Clin Nephrol. 1981;16:172-80. MedlineGoogle Scholar3. COWARDHAMDYSHORTLANDBROWN RNJC. Renal micropolyarteritis: a treatable condition. Nephrol Dial Transplant. 1986;1:31-7. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Vienna Vienna Austria PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Use of Cyclosporine A in Rheumatology: a 2016 Comprehensive ReviewSystemic Vasculitis and Pauci-Immune GlomerulonephritisControl of a relapse and induction of long-term remission of Wegener's granulomatosis by cyclosporineVasculitis, glomerulonephritis and acute renal failurePulmonary vasculitisTreatment of small vessel vasculitis affecting the kidneysRelapsing Wegner's granulomatosis: Successful treatment with cyclosporin-ATherapy of vasculitisClassification, Pathogenesis, and Treatment of Systemic VasculitisThe treatment of Wegener's granulomatosisDiagnosis and Clinical Management of Childhood Vasculitic DiseaseIntravenous immunoglobulin in the therapy of systemic vasculitisImmunopharmacology of Vasculitic SyndromesAutoimmunity in Systemic VasculitisCiclosporin in the treatment of Wegener's granulomatosis (WG) and related diseasesWegener's granulomatosis: otorhinolaryngological manifestationsHigh dose intravenous methylprednisolone pulse therapy in patients with rheumatoid arthritis.Cyclosporin in Wegener's granulomatosis with renal failure.Treatment of polymyalgia rheumatica and giant cell arteritis.Salivary gland involvement in Wegener's granulomatosisNew strategies for plasma exchange in systemic vasculitisSouthwestern Internal Medicine Conference: Immune-complex Vasculitis: Role of Complement and IgG-Fc Receptor Functions 1 March 1988Volume 108, Issue 3Page: 491-491KeywordsCyclophosphamideOpportunistic infectionsProgressive diseasesRenal failureWegener granulomatosis Issue Published: 1 March 1988 PDF downloadLoading ...