Metastatic Carcinoid
Authors: JOSEPH W. ESCHBACH
Journal: Annals of Internal Medicine (1962)

Case Studies1 October 1962Metastatic CarcinoidA Familial OccurrenceJOSEPH W. ESCHBACH, M.D., JOSEPH A. RINALDO JR., M.D.JOSEPH W. ESCHBACH, M.D.Search for more papers by this author, JOSEPH A. RINALDO JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-4-647 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe carcinoid syndrome is characterized by vasomotor phenomena, bronchoconstriction, intestinal hyperperistalsis, and stenosis and insufficieny of the pulmonary and tricuspid valves due to the effects of excessive circulating 5-hydroxytryptamine (serotonin). This symptom complex is rarely found in the absence of metastatic carcinoid tumors. The classical form is not always present. Although isolated carcinoid tumors of the gastrointestinal tract are not uncommon, liver metastases with hyperserotonemia are unusual. Their occurrence in more than one member of the same family has not been reported. This report describes a woman with a well-documented carcinoid syndrome whose brother also had metastatic carcinoid tumor and...References1. KOWLESSARLAWSLEISENGER ODDHMH: Malabsorption syndrome associated with carcinoid tumor. Amer. J. Med. 27: 673, 1959. CrossrefMedlineGoogle Scholar2. THORSON AH: Studies on carcinoid disease. Acta Med. Scand. 161: (supp. 334), 1958. MedlineGoogle Scholar3. MACDONALD RA: A study of 356 carcinoids of the gastrointestinal tract. Amer. J. Med. 21: 867, 1956. CrossrefMedlineGoogle Scholar4. PESKINORLOFF GWMJ: Carcinoids, the malignant carcinoid syndrome and 5-hydroxytryptamine (serotonin). Amer. J. Med. Sci. 237: 224, 1959. MedlineGoogle Scholar5. RITCHIE AC: Carcinoid tumors. Amer. J. Med. Sci. 232: 311, 1956. MedlineGoogle Scholar6. THORSONBIORCKBJORKMANWALDENSTROM AHGGJ: Malignant carcinoid of the small intestine with metastasis to the liver, valvular disease of the right side of the heart (pulmonary stenosis and tricuspid regurgitation without septal defects), peripheral vasomotor symptoms, bronchoconstriction and an unusual type of cyanosis. Amer. Heart J. 47: 795, 1954. CrossrefMedlineGoogle Scholar7. SJOERDSMA A: Serotonin. New Engl. J. Med. 261: 181, 1959. CrossrefMedlineGoogle Scholar8. SJOERDSMAWEISSBACHUDENFRIEND AHS: A clinical, physiologic and biochemical study of patients with a malignant carcinoid. Amer. J. Med. 20: 520, 1956. CrossrefMedlineGoogle Scholar9. SJOERDSMAWEISSBACHTERRYUDENFRIEND AHLLS: Further observations on patients with malignant carcinoid. Amer. J. Med. 23: 5, 1957. CrossrefMedlineGoogle Scholar10. MOLDAWERNARDIRAKER MPGLJW: Concomitance of multiple adenomas of the parathyroids and pancreatic islet cells with tumor of the pituitary: a syndrome with familial incidence. Amer. J. Med. Sci. 228: 190, 1954. CrossrefMedlineGoogle Scholar11. WERMER P: Genetic aspects of adenomatosis of endocrine glands. Amer. J. Med. 16: 362, 1954. CrossrefGoogle Scholar12. SCHMIDLABHARDROSSIER JRAPH: Relationship of multiple endocrine adenomas to the syndrome of ulcerogenic islet cell adenomas (Zollinger-Ellison)—occurrence of both syndromes in one family. Amer. J. Med. 31: 343, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, MichiganRequests for reprints should be addressed to Joseph A. Rinaldo, Jr., M.D., Division of Gastroenterology, Henry Ford Hospital, Detroit 2, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate MultikinaseProfiling of Ileal CarcinoidsCommon pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumorsTumeurs carcinoïdes familiales à localisation rectaleMultiple Endocrine Neoplasia Type 1Complete maternal isodisomy of chromosome 8 in an individual with an early-onset ileal carcinoid tumorGastric carcinoid tumors in a brother-sister occurrence, with special reference to ultrastructural features of endocrine granulesSimilar Rectal Carcinoid Tumors of Two Siblings with Curative Endoscopic Snare ResectionCan susceptibility to carcinoid tumors be inherited?Endokrine Tumoren des DünndarmsDie disseminierten (diffusen) endokrinen ZellenFamilial Occurrence of Metastasizing Carcinoid TumorsC. G. MOERTEL, M.D., F.A.C.P., M. B. DOCKERTY, M.D.Carcinoid tumorsThe CarcinoidHereditary Aspects of Some Less Frequently Occurring Malignancies Exclusive of The Reticuloendothelial SystemThe malignant carcinoid syndromeA familial instance of appendiceal carcinoidEditorialsMedical genetics 1962 1 October 1962Volume 57, Issue 4Page: 647-650KeywordsCarcinoid tumorDiarrheaGastrointestinal tractLiverMetastatic tumorsPeptic ulcersSerotoninStenosis Issue Published: 1 October 1962 PDF DownloadLoading ...