tbuckley/cabot-search huggingface dataset:
In allergic asthma experimental exposure to allergens is associated with depletion of blood eosinophils overexpressing LFA‐1
Authors: S. Lantero, D. Spallarossa, M. Silvestri, F. Sabatini, L. Scarso, E. Crimi, G. A. Rossi
Journal: Allergy (2002)

Background: In atopic individuals, exposure to allergens is followed by recruitment of blood eosinophils in the target tissue. We investigated whether allergen inhalation challenge could result in depletion of blood eosinophils overexpressing adhesion molecules involved in eosinophil migration. Methods: Blood eosinophils were isolated from seven atopic asthmatic patients and seven control subjects and the “at baseline” expression of lymphocyte function‐associated antigen‐1 (LFA‐1), macrophage antigen‐1 (Mac‐1) and very late antigen‐4 (VLA‐4) was assessed by monoclonal antibody staining and flow cytometry analysis. Asthmatic patients underwent allergen challenge and the expression of LFA‐1, Mac‐1 and VLA‐4 by blood eosinophils was again evaluated 3 h and 24 h after allergen challenge. Results: As compared to controls, eosinophils from atopics showed at baseline enhanced LFA‐1 expression ( P =0.0012), but similar Mac‐1 or VLA‐4 expression ( P &gt; 0.1, each comparison). In atopics, the percentage and absolute number of blood eosinophils were significantly decreased 3 h after allergen challenge ( P =0.001 and P =0.022, respectively) but returned to similar values to prechallenge values after an additional 21 h ( P &gt; 0.1). Allergen challenge was also followed by a significant decrease in LFA‐1 expression by eosinophils, at 3 h ( P =0.002) and at 24 h ( P =0.038), while no changes in Mac‐1 and VLA‐4 were observed. A significant correlation between postchallenge decrease in LFA‐1 expression and in blood eosinophilia, both expressed as percentage ( r =0.88; P &lt; 0.01) or absolute number ( r =0.87; P &lt; 0.01) was demonstrated at 3 h ( r =0.88; P &lt; 0.01) but not at 24 h ( r =0.64, P &gt; 0.05 and r=0.11; P &gt; 0.05, respectively). Conclusion: In allergic asthma, an early recruitment of blood eosinophils overexpressing LFA‐1 occurs in the first hours after allergen challenge.
Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice
Authors: Andreas L. Birkenfeld, Hui-Young Lee, Fitsum Guebre-Egziabher, Tiago C. Alves, Michael J. Jurczak, Francois R. Jornayvaz, Dongyang Zhang, Jennifer J. Hsiao, Alejandro Martin-Montalvo, Antje Fischer-Rosinsky, Joachim Spranger, Andreas F. Pfeiffer, Jens Jordan, Martin F. Fromm, Jörg König, Stefanie Lieske, Christopher M. Carmean, David W. Frederick, Dirk Weismann, Felix Knauf, Pablo M. Irusta, Rafael De Cabo, Stephen L. Helfand, Varman T. Samuel, Gerald I. Shulman
Journal: Cell Metabolism (2011)
Interpretation of systolic wall thickening. Can thickening of a discrete layer reflect fibre performance?
Authors: E. Hexeberg, D. C Homans, R. J Bache
Journal: Cardiovascular Research (1995)

Journal Article Interpretation of systolic wall thickening. Can thickening of a discrete layer reflect fibre performance? Get access Erik Hexeberg, Erik Hexeberg * aDepartment of Surgery, University of Bergen, Haukeland Hospital, N-5021 Bergen, Norway *Correspondence to Dr Hexeberg. Search for other works by this author on: Oxford Academic PubMed Google Scholar David C Homans, David C Homans bDepartment of Medicine, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J Bache Robert J Bache bDepartment of Medicine, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 1, January 1995, Pages 16–21, https://doi.org/10.1016/S0008-6363(96)88540-3 Published: 01 January 1995 Article history Received: 03 June 1994 Accepted: 30 August 1994 Published: 01 January 1995
Profuse Haemorrhage from Ruptured Corpus Luteum Simulating an Ectopic Pregnancy
Authors: C. J. Dewhurst
Journal: BMJ (1950)

the remaining eight occurred early and were probably dorsal to the sacrum.SummaryA series of 203 cases of single-injection analgesia and 8 cases of continuous caudal analgesia have been described.The single-injection technique is shown to be an extremely useful method of producing analgesia in vaginal repairs and forceps delivery, and an ideal one for anal operations.In addition it provides training in needle insertion.Some of the difficulties and complications are mentioned.I wish to thank Dr. J. A. Lee for interesting me in caudal analgesia and for continuous help and encouragement; Miss E. M. Whapham, Mrs. F
Acute liver failure: Summary of a workshop
Authors: William M. Lee, Robert H. Squires, Scott L. Nyberg, Edward Doo, Jay H. Hoofnagle
Journal: Hepatology (2008)

Acute liver failure (ALF) is a rare but challenging clinical syndrome with multiple causes; a specific etiology cannot be identified in 15% of adult and 50% of pediatric cases. The course of ALF is variable and the mortality rate is high. Liver transplantation is the only therapy of proven benefit, but the rapidity of progression and the variable course of ALF limit its use. Currently in the United States, spontaneous survival occurs in approximately 45%, liver transplantation in 25%, and death without transplantation in 30% of adults with ALF. Higher rates of spontaneous recovery (56%) and transplantation (31%) with lower rates of death (13%) occur in children. The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia (≈60% spontaneous survival), and poor prognoses with drug-induced ALF, hepatitis B, and indeterminate cases (≈25% spontaneous survival). Excellent intensive care is critical in management of patients with ALF. Nonspecific therapies are of unproven benefit. Future possible therapeutic approaches include N-acetylcysteine, hypothermia, liver assist devices, and hepatocyte transplantation. Advances in stem cell research may allow provision of cells for bioartificial liver support. ALF presents many challenging opportunities in both clinical and basic research. (HEPATOLOGY 2008.)
When actions are carved at the joints
Authors: Merideth Gattis, Harold Bekkering, Andreas Wohlschläger
Journal: Behavioral and Brain Sciences (1998)

We focus on Byrne &amp; Russon's argument that program-level imitation is driven by hierarchically organized goals, and the related claim that to establish whether observed behavior is evidence of program-level imitation, empirical studies of imitation must use multi-stage actions as imitative tasks. We agree that goals play an indispensable role in the generation of action and imitative behavior but argue that multi-goal tasks, not only multi-stage tasks, reveal program-level imitation.
Biomechanics of the elbow joint in tennis players and relation to pathology
Authors: Denise Eygendaal, F Th G Rahussen, R L Diercks
Journal: British Journal of Sports Medicine (2007)

Elbow injuries constitute a sizeable percentage of tennis injuries. A basic understanding of biomechanics of tennis and analysis of the forces, loads and motions of the elbow during tennis will improve the understanding of the pathophysiology of these injuries. All different strokes in tennis have a different repetitive biomechanical nature that can result in tennis-related injuries. In this article, a biomechanically-based evaluation of tennis strokes is presented. This overview includes all tennis-related pathologies of the elbow joint, whereby the possible relation of biomechanics to pathology is analysed, followed by treatment recommendations.
Depolarization-Induced Ca2+ Release in Ischemic Spinal Cord White Matter Involves L-type Ca2+ Channel Activation of Ryanodine Receptors
Authors: Mohamed Ouardouz, Maria A Nikolaeva, Elaine Coderre, Gerald W Zamponi, John E McRory, Bruce D Trapp, Xinghua Yin, Weili Wang, John Woulfe, Peter K Stys
Journal: Neuron (2003)
Generic Drugs: Bioequivalence and Bioavailability-Reply
Authors: Stuart L. Nightingale
Journal: JAMA (1988)

In Reply.  —Dr Ansbacher's letter raises several important points of which prescribers should be aware.  Dr Ansbacher begins by stating that our article did not mention bioavailability. The concept of bioavailability, of course, underlies the entire discussion of bioequivalence, which was the focus of our article. Indeed, in vivo bioequivalence studies are comparative bioavailability studies. Nevertheless, this point is not central to the subject of the letter, which is basically subpotency rather than bioavailability or bioequivalence per se.  We emphasize that, as stated in our article, the Food and Drug Administration (FDA) does not recommend substitution for drugs that have not been designated as therapeutically equivalent. Such drug products account for fewer than 20% of the multisource drugs approved by the FDA for marketing. Conjugated estrogens are a case in point. In our list of approved drugs with therapeutic equivalence evaluations (the Orange Book), 1 we rate all conjugated and
The Pulse-Rate in Pulmonary Tuberculosis
Authors: T. Campbell
Journal: BMJ (1901)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following The Pulse-Rate in Pulmonary Tuberculosis Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Turning the Page at the CMAJ
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (2006)

Since the editor-in-chief and senior deputy editor of the Canadian Medical Association Journal (CMAJ) were fired in February 2006, there has been passionate public debate about editorial independence and the governance of the publication.1,2 In March, the Canadian Medical Association (CMA) appointed a review panel. In July, the panel made its recommendations for change,3 and the association immediately accepted them.4 The report is silent on the underlying reasons for the firings, which may never be publicly clarified.The CMAJ is the leading general health sciences journal in Canada and has been published continuously since 1911.3 Appearing biweekly, it is . . .
Polycystic Ovary Syndrome and Infertility
Authors: Holger S. Willenberg, Maryam Bahlo, Matthias Schott
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Medroxyprogesterone Acetate on Vascular Inflammatory Markers in Postmenopausal Women Receiving Estrogen
Authors: Akihiko Wakatsuki, Yuji Okatani, Nobuo Ikenoue, Takao Fukaya
Journal: Circulation (2002)

Background — Estrogen increases C-reactive protein (CRP) in postmenopausal women. Estrogen also decreases cell adhesion molecules, whereas elevated CRP stimulates the expression of cell adhesion molecules. Because androgens have antiinflammatory effects, androgenic progestins such as medroxyprogesterone acetate (MPA) may inhibit proinflammatory effects of estrogen. We investigated the effects of MPA on estrogen-induced changes in acute inflammatory proteins and cell adhesion molecules in postmenopausal women. Methods and Results — Postmenopausal women were treated daily with conjugated equine estrogen (CEE, 0.625 mg), CEE plus MPA 2.5 mg, or CEE plus MPA 5.0 mg for 3 months. CEE significantly increased CRP concentrations by 320.1±210.2% ( P &lt;0.05). The addition of MPA to CEE, however, inhibited the increase in CRP in a concentration-dependent manner (MPA 2.5 mg, 169.8±66.9%, P &lt;0.05; MPA 5 mg, 55.0±30.4%, not significant). Similarly, CEE increased amyloid A protein concentrations, whereas MPA reversed this effect. Interleukin-6 concentration did not change significantly in any treatment group. CEE alone significantly decreased the concentration of E-selectin, but the concentrations of intercellular adhesion molecule and vascular cellular adhesion molecule did not change significantly. The addition of MPA tended to decrease the levels of cell adhesion molecules, and use of 5.0 mg MPA showed significant decreases in all cell-adhesion molecule concentrations. Conclusions — Concurrent MPA administration may attenuate estrogen’s proinflammatory effect. Because MPA in combination with CEE decreased cell adhesion molecule concentrations, the anti-inflammatory effect of MPA may actually be responsible for the favorable effect of estrogen-progestogen combinations on cell adhesion molecules in postmenopausal women.
Evidences of Arsenical Poisoning
Authors: Walter S. Haines
Journal: JAMA (1913)

<h3>To the Editor:</h3> —In an editorial on this subject inThe Journal, May 31, 1913, p. 1710, it is stated that "by no ordinary measures, such as those to which criminals would be likely to resort, could arsenic be introduced into the body after death and be carried by the ordinary processes of diffusion to a point [the brain] so remote from the central portions of the body." This is so at variance with established facts that I wish to direct your attention to the matter in the interest of medical jurisprudence. It is true, as the editorial points out, that formerly the belief was entertained that if arsenic is found in the brain of a cadaver, the poison must have been introduced into the body before death. During the past thirty years, however, many experiments on the dead bodies of man and of the lower animals have abundantly established
Do Borderline Hypertensive Patients Have Labile Blood Pressure?
Authors: MICHAEL J. HORAN
Journal: Annals of Internal Medicine (1981)

The 24-hour patterns of ambulatory blood pressure were investigated in borderline (labile) hypertensive patients (office blood pressures fluctuating about 140/90 mm Hg). Sixty-three patients (21 normotensive, 21 borderline hypertensive, and 21 fixed hypertensive) had blood pressures recorded every 7.5 to 15 minutes using noninvasive automatic recorders. The mean 24-hour blood pressures (normotensive, 115 +/- 14/74 +/- 12 mm Hg; borderline hypertensive, 127 +/- 16/81 +/- 13 mm Hg; fixed hypertensive, 143 +/- 17/91 +/- 12 mm Hg) were significantly different from each other (p less than 0.005), but the standard deviations were not significantly different. The percentages of elevated blood pressures on the 24-hour recordings of the borderline hypertensive patients were intermediate between those of the normotensive and fixed hypertensive patients, but within the borderline group there was a broad range in percentage of elevated blood pressures (7.9% to 81.2%). Thus, borderline hypertensive patients have blood pressures no more labile than those in normotensive or fixed hypertensive patients, but because of their broad range of percentage of elevated blood pressures, their pressures are best evaluated with multiple measurements.
Kucers’ The Use of Antibiotics
Authors: William A. Petri
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies on the Origin of the Lipid Components of Xanthomata
Authors: JEAN D. WILSON
Journal: Circulation Research (1963)

As the result of in vitro studies of lipid synthesis in slices of rabbit and human xanthomata and of studies on the origin of xanthoma cholesterol in the intact rabbit it has been concluded that although slight amounts of cholesterol may be synthesized in situ, the xanthoma cholesterol is derived predominantly from the blood stream. It has also been demonstrated that the xanthomata possesses the ability to synthesize actively two other lipid components in these lesions--phospholipids and fatty acids.
On Oracles, Education, and the Public Weal
Authors: Nicholas E. Davies
Journal: JAMA (1976)

DELPHI, the seat of the most famous oracle of ancient Greece, was located on a rocky declivity on the southern side of Parnassus. There, questions were asked about future events, and answers were received that were always equivocal and obscure. To assure an answer, questions were accompanied by gifts, often magnificent offerings whose value was in direct proportion to the importance of the question. The answers were given as murmurings by the oracle, and the murmurings were interpreted by nameless priests, undoubtedly contemporary bureaucrats, whose answers tended to uphold and lend support to the religious, political, and civil structures of the time. <h3>The Delphi Method</h3> Man has always wanted to predict the future. Toward this end, the Rand Corporation, during the last decade, devised an interesting experimental device that under certain circumstances may be successful in doing just that.<sup>1</sup>This device is called the Delphi method. Using this method,
Development of 5q‐ myelodysplasia in a patient with sarcoidosis
Authors: Allan R. Tunkel, Kenneth J. Sebastianelli, Niraj Pandit, Jerome I. Brody
Journal: American Journal of Hematology (1990)

Abstract Sarcoidosis has been observed in association with numerous blood dyscrasias including lymphoma, leukemia, and multiple myeloma. This report describes a patient with sarcoidosis and a refractory anemia whose bone marrow karyotype showed deletion of the long arm of chromosome 5, consistent with a myelodysplastic syndrome. Concurrent sarcoidosis and myelodysplasia may relate to the continued availability of cytokines as a consequence of repeated macrophage, T‐cell, and B‐cell interactions, with evolution to the 5q‐ abnormality. This association may merit specific attention in the future approach to the diagnostic evaluation in certain patients with sarcoidosis.
Propagated Vasodilation in the Microcirculation of the Hamster Cheek Pouch
Authors: BRIAN R. DULING, ROBERT M. BERNE
Journal: Circulation Research (1970)

Propagated vasodilation has been observed in the peripheral vasculature and may be significant in integrating the behavior of terminal arterioles and larger vessels. We have studied the characteristics of propagated vasodilation induced by acetylcholine in the microcirculation of the cheek pouch of the golden hamster. The technique of microionophoresis was used as a means of achieving relatively precise temporal and spatial application of drugs to single arterioles. Application of acetylcholine to an arteriole usually resulted in vasodilation which spread rapidly upstream and downstream from the point of application at a rate much greater than could be accounted for by diffusion or by other means of movement of the agent. Longitudinal propagation velocities for a series of arterioles 20 to 40µ in diameter averaged 0.02 cm/sec. The propagated response was relatively specific, being induced by acetylcholine but not by histamine, K + , H + , or eledoisin. The response was graded in both extent and magnitude, was propagated bidirectionally from the point of origin, was observed in vessels as small as 15µ o.d., and could be blocked by lidocaine.
Replication-competent Lentivirus Analysis of Clinical Grade Vector Products
Authors: Kenneth Cornetta, Jing Yao, Aparna Jasti, Sue Koop, Makhaila Douglas, David Hsu, Larry A Couture, Troy Hawkins, Lisa Duffy
Journal: Molecular Therapy (2010)

Lentiviral vectors are now in clinical trials for a variety of inherited and acquired disorders. A challenge for moving any viral vector into the clinic is the ability to screen the vector product for the presence of replication-competent virus. Assay development for replication-competent lentivirus (RCL) is particularly challenging because recombination of vector packaging plasmids and cellular DNA leading to RCL has not been reported with the current viral vector systems. Therefore, the genomic structure of a RCL remains theoretical. In this report, we describe a highly sensitive RCL assay suitable for screening vector product and have screened large-scale vector supernatant, cells used in vector production, and cells transduced with clinical grade vector. We discuss the limitations and challenges of the current assay, and suggest modifications that may improve the suitability of this assay for screening US Food and Drug Administration (US FDA)-licensed products. Lentiviral vectors are now in clinical trials for a variety of inherited and acquired disorders. A challenge for moving any viral vector into the clinic is the ability to screen the vector product for the presence of replication-competent virus. Assay development for replication-competent lentivirus (RCL) is particularly challenging because recombination of vector packaging plasmids and cellular DNA leading to RCL has not been reported with the current viral vector systems. Therefore, the genomic structure of a RCL remains theoretical. In this report, we describe a highly sensitive RCL assay suitable for screening vector product and have screened large-scale vector supernatant, cells used in vector production, and cells transduced with clinical grade vector. We discuss the limitations and challenges of the current assay, and suggest modifications that may improve the suitability of this assay for screening US Food and Drug Administration (US FDA)-licensed products.