Emerging Resistance to Fluoroquinolones in Staphylococci: An Alert
Authors: Michele Trucksis, David C. Hooper, John S. Wolfson
Journal: Annals of Internal Medicine (1991)

Editorials1 March 1991Emerging Resistance to Fluoroquinolones in Staphylococci: An AlertMichele Trucksis, PhD, MD, David C. Hooper, MD, John S. Wolfson, MD, PhDMichele Trucksis, PhD, MD, David C. Hooper, MD, John S. Wolfson, MD, PhDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-5-424 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe fluoroquinolones are orally administered antimicrobial agents introduced in the mid-1980s. Although they are particularly effective for treating gram-negative bacillary infections, some agents, including ciprofloxacin, ofloxacin, and pefloxacin, are also active against gram-positive organisms. These agents have shown promise as alternatives to parenteral vancomycin for treating infections with methicillin-resistant Staphylococcus aureus. With fluoroquinolone use, however, therapeutic failures associated with isolation of fluoroquinolone-resistant strains of staphylococci are being increasingly documented. We discuss the use of fluoroquinolones as therapeutic agents for staphylococcal infections, problems with bacterial resistance, and approaches to suppression of resistance.Staphylococci have long been important causes of both community-...References1. HoranCulverJarvis TDW. Pathogens causing nosocomial infections: preliminary data from the national nosocomial infections surveillance system. Antimicrobic Newsletter. 1988;5:65-7. CrossrefGoogle Scholar2. BarryJones AR. In vitro activity of ciprofloxacin against gram-positive cocci. Am J Med. 1987;82(Suppl 4A):27-32. MedlineGoogle Scholar3. Mitsuhashi S. Comparative antibacterial activity of new quinolone-carboxylic acid derivatives. Rev Infect Dis. 1988;10(Suppl. 1):S27-31. CrossrefMedlineGoogle Scholar4. EspinozaChinNovelliNeu ANAH. 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Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital Harvard Medical School Boston, MA 02114-2696 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOpportunities to Improve Fluoroquinolone Prescribing in the United States for Adult Ambulatory Care VisitsAntimicrobial Prophylaxis in HematologyQuinolonesAntibacterial activities of nemonoxacin against clinical isolates of Staphylococcus aureus: an in vitro comparison with three fluoroquinolonesTreatment of Experimental and Human Bacterial Endocarditis with Quinolone Antimicrobial AgentsHigh expression of a plectasin-derived peptide NZ2114 in Pichia pastoris and its pharmacodynamics, postantibiotic and synergy against Staphylococcus aureusCiprofloxacinSurmounting antimicrobial resistance in the Millennium Superbug: Staphylococcus aureusGender Differences in Emerging Infectious DiseasesQuinolonesBarrier precautions, prophylaxis and neutropenic feverThe Use of 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