tbuckley/cabot-search huggingface dataset:
An Electromicroscopic Study of the Thiamine-Deficient Rat Heart.
Authors: F. Eugene Tubbs
Journal: Annals of Internal Medicine (1966)

s1 May 1966An Electromicroscopic Study of the Thiamine-Deficient Rat Heart.F. Eugene Tubbs, M.D., Yoshiharu Sako, M.D., Lamar E. Crevasse, M.D. (Associate)F. Eugene Tubbs, M.D.Search for more papers by this author, Yoshiharu Sako, M.D.Search for more papers by this author, Lamar E. Crevasse, M.D. (Associate)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1154_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThiamine-deficient hearts have been demonstrated by light microscopy to show interstitial edema with hydropic and fatty degeneration of the myocardial fibers. This report is the first ultrastructure study of thiamine-deficient cardiac muscle. Twenty-four adult male Sprague-Dawley rats were divided into two groups. Controls were fed a standard balanced diet containing 2.2 mg of thiamine 100 g of diet. The other group received the same diet, without thiamine. The thiamine-deficient group rapidly developed beri-beri, manifest by weakness, weight loss, epilation and labored respirations. They were given 5 µg of thiamine occasionally to maintain life and induce a chronic deficient state. After... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: F. Eugene Tubbs, M.D.; Yoshiharu Sako, M.D.; Lamar E. Crevasse, M.D. (Associate)Affiliations: Gainesville, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1154-1154KeywordsCardiac musclesDietEdemaHeartLight microscopyLongitudinal studiesRespirationThiamineWeight loss ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
Costs of New Treatments for Hepatitis C Infection—Reply
Authors: Troyen A. Brennan, William H. Shrank
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum cytokine levels related to multiple dimensions of fatigue in patients with primary Sjogren's syndrome
Authors: A. Hartkamp, R Geenen, Marc Bijl, A.A. Kruize, G.L R Godaert, R.H.W.M. Derksen
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objective:</b> To test whether serum levels of selected cytokines relate to different dimensions of fatigue in patients with primary Sjögren's syndrome (pSS). <b>Methods:</b> Sixty female patients with pSS filled out a questionnaire to assess multiple dimensions of fatigue. Scores were compared with values in a population based control group (n = 139). Levels of interleukin (IL)1β, IL2, IL6, IL10, and tumour necrosis factor α were measured in serum with commercial sandwich ELISAs. The relationship between self reported dimensions of fatigue and these serum cytokine levels was determined. <b>Results:</b> Patients with pSS had high scores at all dimensions of fatigue (p&lt;0.001): general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue. Fatigue levels were not related to serum cytokine levels. The incidental finding that reduced motivation was higher in patients with detectable serum levels of IL10 (p = 0.04) disappeared after correction for multiple testing. <b>Conclusion:</b> Fatigue is prominent in patients with pSS and involves all dimensions of fatigue. The findings do not suggest a widespread effect of circulating cytokines on multiple aspects of fatigue.
The regulation of vascular smooth muscle cell apoptosis
Authors: Nicola J. McCarthy, Martin R. Bennett
Journal: Cardiovascular Research (2000)

Apoptosis describes the morphological changes that identify a specific form of regulated cell death. Over recent years, the importance of either aberrant onset or suppression of apoptosis within tissues has become apparent and is associated with the development of several terminal diseases. Here we describe the relevance of apoptosis to the maintenance of vascular homeostasis. Specifically, we address the role of vascular smooth muscle cell death, how this may be regulated at the molecular level and whether any of these molecular mediators will provide targets for intervention in diseases such as atherosclerosis.
Trends in the Incidence and Survival of Patients with Hospitalized Myocardial Infarction, Olmsted County, Minnesota, 1979 to 1994
Authors: Véronique L. Roger, Steven J. Jacobsen, Susan A. Weston, Tauqir Y. Goraya, Jill Killian, Guy S. Reeder, Thomas E. Kottke, Barbara P. Yawn, Robert L. Frye
Journal: Annals of Internal Medicine (2002)

Evidence indicates that deaths from coronary disease are decreasing less in elderly persons and women. Understanding the determinants of these trends is important for prevention.To test the hypothesis that trends in incidence and survival of hospitalized myocardial infarction differ according to sex and age.Longitudinal observational study.Community-dwelling persons in Olmsted County, Minnesota.5117 patients who had an estimated 1820 incident myocardial infarctions from 1979 to 1994.Myocardial infarctions were validated by using epidemiologic criteria. Rates were directly adjusted to the age distribution of the 2000 U.S. population.Of the 1820 incident infarctions, 44% occurred in women and 36% in persons 75 years of age or older. In 1979, the age-adjusted incidence of myocardial infarction was 205 per 100 000 persons (95% CI, 162 to 247 per 100 000 persons). Between 1979 and 1994, the age-adjusted incidence of myocardial infarction decreased by 8% (CI, -23% to 10%) in men but increased by 36% (CI, 9% to 70%) in women. A 31% decrease in the incidence of infarction over time was observed in men 40 years of age compared with a 49% increase in women 80 years of age. Survival improved predominantly in younger persons.Over time, the incidence of hospitalized infarction decreased in men but increased in women and elderly persons. Survival benefits were clustered among younger persons. These results suggest that both incidence and survival contribute to the contrasting mortality trends by age and sex and that the burden of coronary disease has shifted toward elderly persons, a finding that has public health implications in an aging population.
Myocardial infarction with minimal coronary atherosclerosis in the era of thrombolytic reperfusion
Authors: Dean J. Kereiakes, Eric J. Topol, Barry S. George, Richard S. Stack, Charles W. Abbottsmith, Stephen Ellis, Richard J. Candela, Lynn Harrelson, Linda H. Martin, Robert M. Califf
Journal: Journal of the American College of Cardiology (1991)
LOCAL ANESTHESIA BY QUININ SALTS AND THE COMMITTEE REPORT
Authors: Edward J. Brown
Journal: JAMA (1923)

ABSTRACT To the Editor: —A communication by me with this title was published in The Journal, Sept. 18, 1920, and the September, 1920, Laryngoscope, in which I gave my experience with the quinin salts, and expressed the opinion that the committee of the Section on Laryngology, Otology and Rhinology on local anesthetics had not quite done justice to quinin as a local anesthetic. I had lately used quinin hydrochlorid, 1 grain in 2 drams of distilled water, with entire satisfaction. Shortly afterward, a patient had a slight slough of the wound, and I reduced the strength of solution to ¾ grain in 2 drams, since which time I have had no case of sloughing, and the anesthesia has been satisfactory. I then began the practice of using this strength of quinin hydrochlorid for the right tonsil and 0.2 per cent, of cocain for the left (5 c.c.) to secure comparative results.
Brain Scans, Dexamethasone Therapy, and Brain Tumors
Authors: James W. Fletcher, Erica A. George, Robert E. Henry, Robert M. Donati
Journal: JAMA (1975)

Eight men with primary or metastatic brain tumors were examined with brain scans before and after the administration of dexamethasone. All patients demonstrated some improvement in their clinical neurologic status during therapy, and two patients had a dramatic response. Seven of the eight patients examined showed a decrease in the apparent size of the original lesion on recent brain scan while receiving dexamethasone. Comparison of immediate scans obtained 15 to 20 minutes following the administration of sodium pertechnetate Tc 99m with those obtained two or three hours later suggests that the change in apparent size of the original lesion results from decrease in peritumor edema.
Floods in southern Africa result in cholera outbreak and displacement
Authors: Pat Sidley
Journal: BMJ (2008)

A cholera outbreak has hit Mozambique after severe flooding, with many people dying from the disease, which has spread to the capital, Maputo.

Aid agencies, such as Medicins Sans Frontieres, said that more than 70 people had died, but Mozambique’s health ministry, working from registered cases, put the figure at 48.

Mozambique’s plight has been mirrored in Zambia and Zimbabwe, with Unicef reporting that about 70 000 Zambian families have been displaced by the floods and their homes destroyed, Unicef said last week.

One concern that Unicef is trying to tackle is the availability of treatment for people with AIDS, …
Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patients
Authors: J.K. Inrig, E.Z. Oddone, V. Hasselblad, Barbara Gillespie, U.D. Patel, D. Reddan, R. Toto, J. Himmelfarb, J.F. Winchester, J. Stivelman, R.M. Lindsay, L.A. Szczech
Journal: Kidney International (2007)
Pathological Anatomy of Acute Hypertension of Pregnancy
Authors: CHARLES P. MCCARTNEY
Journal: Circulation (1964)

With the possible exception of a unique glomerular lesion, the morphological changes in patients dying with convulsions, coma, and other complications of acute hypertension are not specific for a pathological entity initiated by aberrations peculiar to the pregnant state. Renal biopsies afford a means for classifying pregnant patients with acute hypertension. The glomerular lesion, believed to be pathognomonic of preeclampsia, was not found in 25% of 63 primiparas who fulfilled the clinical criteria for preeclampsia; chronic renal disease was present without the toxemic lesion in 30% of 214 pregnant patients with acute hypertension. These findings suggest that chronic renal disease plays a more important role in the acute hypertension of pregnancy than current statistics indicate, and that data pertaining to the hypertensive disorders of pregnancy must be interpreted with caution when their differentiation is based upon clinical criteria alone.
Rim2α Determines Docking and Priming States in Insulin Granule Exocytosis
Authors: Takao Yasuda, Tadao Shibasaki, Kohtaro Minami, Harumi Takahashi, Akira Mizoguchi, Yoshitsugu Uriu, Tomohiro Numata, Yasuo Mori, Jun-ichi Miyazaki, Takashi Miki, Susumu Seino
Journal: Cell Metabolism (2010)
Inhumane starting point
Authors: F. W. Arnold
Journal: BMJ (2010)

Detention of “failed” asylum seekers for the administrative convenience of the UK Border Agency should only be for lawful removal from the UK and for the shortest possible time, but in practice it is indeterminate and can last for years.1

Many detainees are eventually found to have been inappropriately detained and are allowed to remain in the UK because they risk persecution in their …
Lack of benefit of early routime invasive strategy in reducing reinfarction rate in high-risk patients after thrombolysis (results of a randomized trial: SIAM-I)
Authors: Bernd Hammer, Cem Özbek, Jan Dyckmans, Semi Sen, Benno Hennen, Volker Hilpert, Hermann Schieffer
Journal: Journal of the American College of Cardiology (1991)
Facilitation of noradrenaline release by activation of adenosine A2A receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery
Authors: P FRESCO
Journal: Cardiovascular Research (2004)

The present work is aimed at elucidating the signalling pathway(s) triggered by activation of A(2A) receptors involved in the facilitation of noradrenaline release in rat tail artery as an attempt to clarify their role in the cardiovascular system.Electrically evoked (5 Hz, 100 pulses, 1 ms) tritium overflow was evaluated in preparations of rat tail artery, pre-incubated with [(3)H]-noradrenaline (0.1 microM), in the absence or in the presence of adenosine receptor agonists and antagonists and/or activators and inhibitors of phospholipase C (PLC)-protein kinase C (PKC) and of adenylate cyclase (AC)-cyclic adenosine-3',5'-monophosphate (cAMP)-protein kinase A (PKA) pathways.Activation of A(2A) receptors by 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680; 100 nM) enhanced tritium overflow, an effect prevented by the A(2A) receptor antagonist 5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo-[4,3]-1,2,4-triazolo[1,5]pyrimidine (SCH 58261; 20 nM), by the protein kinase A (PKA) inhibitor N-(2-[p-bromocinnamylamino]ethyl)-5-isoquinolinesulfonamide (H-89; 1 microM), or the PKC inhibitor 2-(8-[(dimethylamino)methyl-6,7,8,9-tetrahydropyrido[1,2]indol-3-yl]-3-(1-methylindol-3-yl)maleimide (Ro 32-0432; 1 microM). The PKC activator phorbol 12-myristate 13-acetate (PMA; 1 microM) and the PKA activator 8-bromo-cAMP (0.5 mM) also enhanced tritium overflow. The effect caused by PMA was blunted both by Ro 32-0432 and by H-89 whereas that caused by 8-bromo-cAMP was only prevented by H-89.In rat tail artery, the A(2A) receptor-mediated facilitation of noradrenaline release requires activation of both PKC and PKA, and PKA activation seems to occur downstream of PKC activation.
878 ALLOGENEIC ADOPTIVE IMMUNOTHERAPY OF THE HEPATOCELLULAR CARCINOMA BY INFUSION OF “READY-TO-USE” ALLOGENEIC SUICIDE GENE-MODIFIED T CELLS
Authors: C. Leboeuf, L. Mailly, C. Ferrand, P. Tiberghien, P. Wolf, M. Doffoel, T.F. Baumert, E. Robinet
Journal: Journal of Hepatology (2010)
Abstract 109: PET imaging of 89Zr-labeled Pertuzumab in HER2-positive breast cancer xenografts
Authors: Bernadette V. Marquez, Oluwatayo F. Ikotun, Brian Wright, Alexander Zheleznyak, Pierce Richard, Suzanne E. Lapi
Journal: Cancer Research (2014)

Abstract The sensitivity and quantitative properties of Positron Emission Tomography (PET) imaging combined with the selectivity and high affinity of radiolabeled monoclonal antibodies (mAbs) make a powerful tool in molecular imaging of diseases including breast cancer. Radiolabeling mAbs with the positron-emitting 89Zr has recently been useful in clinical trials due to its relatively long half-life (t1/2 = 3.3 days), which matches the pharmacokinetic properties of mAbs. Pertuzumab (Perjeta™) is an FDA-approved mAb for the treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer, in combination with Trastuzumab (Herceptin™) and chemotherapy. Herein, we evaluated 89Zr-labeled Pertuzumab as a PET imaging agent in transgenic mice-bearing human breast cancer. The 89Zr chelator, p-isothiocyanatobenzyl-desferrioxamine, was conjugated to Pertuzumab and subsequently radiolabeled with 89Zr. The immunoreactivity and specificity of 89Zr-Pertuzumab for HER2-expressing cells were determined in vitro and showed retention of 89Zr-Pertuzumab immunoreactivity and specific binding to HER2-expressing cells. Human breast cancer cells were inoculated subcutaneously in severely immunocompromised NOG mice, a model which allows for the growth of HER2-positive tumors without exogenous stimuli. 89Zr-Pertuzumab was injected via tail vein and imaged and 5 and 7 days post-injection (p.i.) followed by biodistribution studies. Optimal contrast was achieved at 5 days p.i., with higher tumor uptake in the HER2-positive xenograft than the HER2-negative model. Immunohistochemical analysis of these tumors is in agreement with PET imaging analysis. These results illustrate that 89Zr-Pertuzumab may be beneficial for the noninvasive assessment of HER2 expression. Citation Format: Bernadette V. Marquez, Oluwatayo F. Ikotun, Brian Wright, Alexander Zheleznyak, Pierce Richard, Suzanne E. Lapi. PET imaging of 89Zr-labeled Pertuzumab in HER2-positive breast cancer xenografts. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 109. doi:10.1158/1538-7445.AM2014-109
Is testing everyone for HIV logical?
Authors: J. C McILwain
Journal: BMJ (2003)

EDITOR—Ammann in his editorial on preventing HIV is either being deliberately provocative or has got it entirely wrong.1 Testing everyone for HIV, regardless of perceived risk factors, to break down the barrier that HIV only affects “us” and not “me,” is likely to do exactly the opposite. Labelling people as “having” and “not having” foments discrimination: it …
1006-41 Effect of Previous Treatment with Aspirin or Nitrates on the Clinical Manifestation of Acute Coronary Syndrome
Authors: David Garcia-Dorado, Juan Oliveras, Pilar Tornos, Gaietà Permanyer, Antonia Sambola, Maite Santos, Pierre Théroux, J. Soler-Soler
Journal: Journal of the American College of Cardiology (1995)
Active Constriction of Small Pulmonary Arteries in Rabbit
Authors: DALI J. PATEL, ALAN C. BURTON, Mrs. Dorothy Elston
Journal: Circulation Research (1957)

This communication deals with the demonstration of active pulmonary vasomotion by injecting plastic material (vinyl acetate) which forms casts of the small pulmonary arteries simultaneously on a control side and on the test side submitted to action of vasoconstrictor drugs. Comparisons were made by direct microscopic observations and by weighing the casts after the lung tissue had been digested. Other indices such as relative weight of the two lungs, relative denseness of vascularity and estimates of pulmonary resistance supplied supplementary evidence of pulmonary vasomotion.
Rationing in the NHS: audit of outcome and acceptance of restriction criteria for minor operations
Authors: C. P O'Boyle, R. P Cole
Journal: BMJ (2001)

Dextropropoxyphene was dispensed with alprazolam on 261 occasions (this combination may increase the central depressant effects of alprazolam) and with carbamazepine on 240 (this combination may cause serious toxic effects by increasing plasma concentrations of carbamazepine).Cisapride was dispensed with erythromycin on five occasions, with clarithromycin on three, fluconazole on 24, and itraconazole on one; any of these combinations may result in torsades de pointes, syncope, cardiac arrest, and sudden death. CommentAlthough the percentage of potential drug interactions that may have serious clinical consequences (type D) was low (1.4%), serious and potentially fatal drug interactions-for example, NSAID and warfarin, potassium supplements and potassium sparing diuretics, dextropropoxyphene and carbamazepine, and cisapride and fluconazole-were detected.The risk of interactions with cisapride was known in 1996, 5 and cisapride, which is still available in Sweden, is being withdrawn in many countries.Prescribing pairs of drugs with potential interactions increases the risk of, but need not lead to, an adverse reaction.Many drug interactions are susceptible to control by dose adjustment; moreover, some are beneficial and are exploited in therapeutics.National monitoring of potential drug interactions in Sweden is feasible.Differences in healthcare systems need to be considered when extrapolating the results of this study to other countries.
Follicular dendritic cells inhibit apoptosis in human B lymphocytes by a rapid and irreversible blockade of preexisting endonuclease.
Authors: E Lindhout, A Lakeman, C de Groot
Journal: The Journal of Experimental Medicine (1995)

During germinal center reactions, a minority of B lymphocytes are selected after successful binding to follicular dendritic cells (FDCs). The majority of the B cells, however, die by apoptosis. One of the characteristics of apoptosis is rapid fragmentation of DNA by an endogenous endonuclease. The regulation of apoptosis and endonuclease activity in germinal center (GC) B cells is largely unknown. In this study we have investigated the induction and inhibition of endonuclease activity in GC B cells. We also investigated the role of FDCs, surface Ig (sIg), sIgM, CD21, CD22 CD40, and intracellular Zn2+ in the regulation of endonuclease activity. We have found that DNA fragmentation in GC B cells is caused by a preexisting endonuclease very similar to NUC-18 (an 18-kD endonuclease identified in rat thymocytes). Endonuclease activity in GC B cells appears to be rapidly and irreversibly blocked after interaction with FDCs, but not after cross-linkage of sIg, sIgM, CD21, CD22, or CD40. Addition of soluble CD40-human IgM fusion protein (sCD40) to FDC-B cell cultures also did not interfere with FDC-mediated B cell rescue. Chelation of intracellular Zn2+ during FDC-B cell cultures resulted in abrogated B cell rescue. These data suggest that FDCs inhibit apoptosis in GC B cells by a rapid inactivation of preexisting endonuclease using a mechanism distinct from CD40 ligation.
Paediatrician calls for shake up in handling child abuse cases
Authors: L. Eaton
Journal: BMJ (2003)

A radical shake up is needed in the way child protection cases are tackled, with a harder line being taken when professionals suspect premeditated abuse, argue UK paediatricians in two articles in the latest issue of Archives of Disease in Childhood (2003;88:101-4, 105-7).

The authors of the two papers are consultant paediatricians Professor David Southall and Dr Martin Samuels of North Staffordshire, Stoke on Trent, and Michael Golden, emeritus professor of medicine, University of Aberdeen.

Professor Southall and …