Nephrogenic Diabetes Insipidus Associated with Foscarnet Treatment of Cytomegalovirus Retinitis
Authors: Robert V. Farese
Journal: Annals of Internal Medicine (1990)

Brief Reports15 June 1990Nephrogenic Diabetes Insipidus Associated with Foscarnet Treatment of Cytomegalovirus RetinitisRobert V. Farese Jr., MD, Morris Schambelan, MD, Harry Hollander, MD, Suzan Stringari, RN, MSN, Mark A. Jacobson, MDRobert V. Farese Jr., MDSearch for more papers by this author, Morris Schambelan, MDSearch for more papers by this author, Harry Hollander, MDSearch for more papers by this author, Suzan Stringari, RN, MSNSearch for more papers by this author, Mark A. Jacobson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-12-955 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNephrogenic diabetes insipidus occurs both as a rare X-linked genetic disorder and, more commonly, as a complication of therapy with lithium carbonate and various other drugs (1). We report a case of a patient with the acquired immunodeficiency syndrome (AIDS) who developed nephrogenic diabetes insipidus as a complication of treatment of cytomegalovirus (CMV) retinitis with foscarnet (trisodium phosphonoformate).Case ReportA 37-year-old homosexual man was hospitalized at the General Clinical Research Center at San Francisco General Hospital for evaluation of polydipsia and polyuria. He had been diagnosed with AIDS more than 2.5 years earlier when he developed Kaposi sarcoma. Subsequently,...References1. SingerForrest IJ. Drug-induced states of nephrogenic diabetes insipidus. Kidney Int. 1976;10:82-95. CrossrefMedlineGoogle Scholar2. JacobsonO'DonnellMills MJJ. Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. Antimicrob Agents Chemother. 1989;33:736-41. CrossrefMedlineGoogle Scholar3. MillerDalakosMosesFellermanStreeten MTAHD. Recognition of partial defects in antidiuretic hormone secretion. Ann Intern Med. 1970;73:721-9. LinkGoogle Scholar4. WalmsleyChewRead SES. Treatment of cytomegalovirus retinitis with trisodium phosphonoformate hexahydrate (foscarnet). J Infect Dis. 1988;157:569-72. CrossrefMedlineGoogle Scholar5. KlintmalmLonnqvistOberg GBB. Intravenous foscarnet for the treatment of severe cytomegalovirus infection in allograft recipients. Scand J Infect Dis. 1985;17:157-63. CrossrefMedlineGoogle Scholar6. RingdenLonnqvistPaulin OBT. Pharmacokinetics, safety and preliminary clinical experiences using foscarnet for the treatment of cytomegalovirus infections in bone marrow and renal transplant recipients. J Antimicrob Chemother. 1986;17:373-87. CrossrefMedlineGoogle Scholar7. SjovallBergdahlMovinOgenstadSaarimaki JSGSM. Pharmacokinetics of foscarnet and distribution to cerebrospinal fluid after intravenous infusion in patients with human immunodeficiency virus infection. Antimicrob Agents Chemother. 1989;33:1023-31. CrossrefMedlineGoogle Scholar8. Robertson G. Diagnosis of diabetes insipidus. In: Czernichow AP, Robinson A, eds. Diabetes Insipidus in Man: Frontiers of Hormone Research, v 13. New York: Karger; 1985:127-55. CrossrefGoogle Scholar9. YusufiSzczepanska-KonkelKempsonMcAteerDousa AMSJT. Inhibition of human renal epithelial Na+/Pi cotransport by phosphonoformic acid. Biochem Biophys Res Commun. 1986;139:679-86. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert V. FareseJr., MD; Morris Schambelan, MD; Harry Hollander, MD; Suzan Stringari, RN, MSN; Mark A. Jacobson, MDFrom San Francisco General Hospital, San Francisco, California; and AIDS Clinic, University of California San Francisco, San Francisco, California. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFoscarnet-Associated Nephrogenic Diabetes InsipidusHypernatremic StatesElectrolyte disturbances associated with commonly prescribed medications in the intensive care unitNéphropathies rencontrées au cours de l’infection par le virus de l’immunodéficience humaine (VIH)The Renal SystemAntiviral agentsHypernatremic StatesHIV-1 Infection and the Kidney: An Evolving Challenge in HIV MedicineAntiretroviral therapy and the kidney: balancing benefit and risk in patients with HIV infectionNéphropathies rencontrées au cours de l'infection par le virus de l'immunodéficience humaine (VIH)Causes of reversible nephrogenic diabetes insipidus: A systematic reviewDrugs and the retinaAntiviral agentsNEUROENDOCRINE ABNORMALITIES ASSOCIATED WITH HIV INFECTIONFoscarnet-Induced Electrolyte Abnormalities in a Bone Marrow Transplant Patient Receiving Parenteral NutritionAdipsic hypernatremia in two patients with aids and cytomegalovirus encephalitisEffects of Etoposide (VP16) on Vertebrate Retinal FunctionRenal Complications of Intravenous Drug Abuse and Human Immunodeficiency Virus InfectionAntiviral agentsENDOCRINOLOGIC COMPLICATIONS OF HIV INFECTIONEndocrine Implications of Human Immunodeficiency Virus InfectionNephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapyNew Aspects of Oral Viral DiseasesFoscarnet alters antidiuretic hormone-mediated transportPharmacology and clinical use of foscarnet1 Aetiology and pathogenesis of hormonal and metabolic disorders in HIV infection2 Hypothalamic and pituitary function in AIDSConcurrent Use of Foscarnet and Ciprofloxacin May Increase the Propensity for SeizuresCytomegalovirus: a virus of increasing relevance to oral medicine and pathologyFamotidinAntiviral drugsSystemic antiviral drugs used in ophthalmologyMaintenance therapy for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome: FoscarnetCentral diabetes insipidus: a complication of herpes simplex type 2 encephalitis in a patient with aidsCentral diabetes insipidus: A complication of herpes simplex type 2 encephalitis in a patient with AIDS 15 June 1990Volume 112, Issue 12Page: 955-956KeywordsAIDSEndocrinologyHomosexualsHospitalsKaposi sarcomaLungsMedical servicesOral medicineResearch grantsRetinitis ePublished: 1 December 2008 Issue Published: 15 June 1990 PDF downloadLoading ...