tbuckley/cabot-search huggingface dataset:
Abstract C37: Reduced annexin A6 expression enhances EGFR degradation and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors
Authors: Rainelli B. Koumangoye, Josiah Ochieng, Amos M. Sakwe
Journal: Cancer Research (2013)

Abstract The role of annexin A6 (AnxA6), a calcium-dependent phospholipid binding protein, in breast carcinogenesis remains poorly understood. Some reports suggest that AnxA6 inhibits the activation and down-stream signaling of epidermal growth factor receptor (EGFR). On the contrary, other studies have shown that AnxA6 not only stabilizes activated receptors on the cell surface but also promotes the expression of differentiation markers in chondrocytes. Together with our recent study showing that AnxA6 expression is reduced in breast cancer, we investigated whether AnxA6 expression status influences breast cancer outcome in patients and whether this may be attributed to its modulation of EGFR expression. We show that low AnxA6 expression correlates with reduced distant metastasis-free and overall survival, but is associated with a higher probability for recurrence-free survivalof patients with basal-like breast cancer. To determine whether these effects are mediated via EGFR, a predictive marker of basal-like breast cancer, we examined the effects of altered expression of AnxA6 in AnxA6-high invasive triple negative breast cancer cells. Interestingly, depletion of AnxA6 in invasive BT-549 cells was accompanied by decreased expression of EGFR protein and mRNA. We also show that in invasive breast cancer cells, AnxA6 expression is required for sustained membrane localization of activated EGFR and persistent downstream signaling. Consequently, AnxA6-depleted cells exhibited decreased cell motility, and increased sensitivity to the tyrosine kinase inhibitors (TKIs), lapatinib and PD153035. On the contrary, over-expression of AnxA6 in AnxA6-low HCC1806 cells did not affect their motility but as expected, inhibited their growth in 3D matrigel cultures. These data suggest that AnxA6-modulation of EGFR expression and activity underlies at least in part, the changes in proliferation, metastatic potentials and sensitivity to EGFR-targeted TKIs of invasive breast cancer cells. Our data also suggest that AnxA6 expression status may predict the survival and likelihood to respond to EGFR-targeted therapies of patients with basal-like breast cancer. Citation Format: Rainelli B. Koumangoye, Josiah Ochieng, Amos M. Sakwe. Reduced annexin A6 expression enhances EGFR degradation and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr C37.
Human Chorionic Gonadotropin — A Hormone Secreted for Many Reasons
Authors: Judith L. Vaitukaitis
Journal: New England Journal of Medicine (1979)

Human chorionic gonadotropin, a glycoprotein hormone secreted in large quantities by the placenta, normally circulates at readily detectable levels only during gestation. It shares a common quaternary structure of two dissimilar subunits (designated alpha and beta) with the pituitary glycoprotein hormones luteinizing hormone, follicle-stimulating hormone and thyroid-stimulating hormone. Although the amino-acid sequences of the alpha subunits of the human glycoprotein hormones are essentially identical, those of the beta subunits differ and account for the unique immunologic and biologic activities of each glycoprotein hormone.1 Although luteinizing hormone and human chorionic gonadotropin have biologic activities in common, reflecting the 80 per cent . . .
Intravascular air and CT
Authors: W-J Lee, K-L Liu, S-J Chen
Journal: Thorax (2007)

Dr Ku and co-workers wrote an interesting article describing a patient with air emboli in the superior vena cava surrounding a central venous catheter (CVC) and bilateral pulmonary opacities recognised on contrast enhanced chest CT.1 The round pulmonary opacity was noted on chest radiograph soon after insertion …
Levels of house‐dust‐mite allergen in homes of nonallergic people in Pavia, Italy
Authors: G. Moscato, L. Perfetti, E. Galdi, V. Pozzi, C. Minoia
Journal: Allergy (2000)

HDM distribution varies between geographic areas and may be affected by housing characteristics. We quantified Der p 1 and Der f 1 and assessed the relationships between their levels and housing characteristics in homes of nonallergic subjects.Der f 1 and Der p 1 were measured by ELISA in dust samples from living-room floors and mattresses of 44 homes of nonallergic subjects in Pavia. Information about household characteristics was obtained by questionnaire.Der p 1 and Der f 1 concentrations (microg/g dust, median) were 0.34 and 7.8 on mattresses, and 0.15 and 0.83 on living-room floors. Higher Der f 1 levels on mattresses were associated with synthetic pillows (P<0.05), and (only when expressed as microg/m2) with bedding washing temperature of < or = 60 degrees C (P<0.05). Der f 1 levels were higher on the living-room floors of homes located on lower (< or =first) floors (P<0.05). Good correlations were found between Der p 1 and Der f 1 expressed as microg/g dust and microg/m2 on both mattresses and living-room floors.In homes of nonallergic subjects in northern Italy, Der f 1 exceeded the threshold for sensitization in a high proportion of mattress samples.
Arterial Calcification and Gangrene in Uremia
Authors: Sandor A. Friedman, Stuart Novack, Gerald E. Thomson
Journal: New England Journal of Medicine (1969)

CHRONIC renal failure is often accompanied by metastatic calcification. In the two uremic patients described below severe arterial calcification and extensive gangrene of the upper extremities developed.Case ReportCase 1. R.L., a 29-year-old man, was first hospitalized because of fatigue, hypertension and uremia. He gave a 10-year history of proteinuria. Wrist pulses were normal. For 6 months he received intermittent peritoneal dialysis. He was then readmitted to the hospital because of severe pain in the right thumb and left 4th and 5th fingers.Examination was within normal limits except for peripheral edema, a blood pressure of 150/110 and the . . .
Future trends in cystic fibrosis demography in 34 European countries
Authors: Pierre-Régis Burgel, Gil Bellis, Hanne V. Olesen, Laura Viviani, Anna Zolin, Francesco Blasi, J. Stuart Elborn
Journal: European Respiratory Journal (2015)

Median survival has increased in people with cystic fibrosis (CF) during the past six decades, which has led to an increased number of adults with CF. The future impact of changes in CF demographics has not been evaluated. The aim of this study was to estimate the number of children and adults with CF in 34 European countries by 2025. Data were obtained from the European Cystic Fibrosis Society Patient Registry. Population forecasts were performed for countries that have extensive CF population coverage and at least 4 years of longitudinal data by modelling future entering and exiting flows in registry cohorts. For the other countries, population projections were performed based on assumptions from knowledge of current CF epidemiology. Western European countries’ forecasts indicate that an increase in the overall number of CF patients by 2025, by approximately 50%, corresponds to an increase by 20% and by 75% in children and adults, respectively. In Eastern European countries the projections suggest a predominant increase in the CF child population, although the CF adult population would also increase. It was concluded that a large increase in the adult CF population is expected in the next decade. A significant increase in adult CF services throughout Europe is urgently required.
Sustained exposure to bacterial antigen induces interferon-γ-dependent T cell receptor ζ down-regulation and impaired T cell function
Authors: Noemí Bronstein-Sitton, Leonor Cohen-Daniel, Ilan Vaknin, Analía V Ezernitchi, Benny Leshem, Amal Halabi, Yael Houri-Hadad, Eugenia Greenbaum, Zichria Zakay-Rones, Lior Shapira, Michal Baniyash
Journal: Nature Immunology (2003)
A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma
Authors: Benjamin Ory, Matthew R. Ramsey, Catherine Wilson, Douangsone D. Vadysirisack, Nicole Forster, James W. Rocco, S. Michael Rothenberg, Leif W. Ellisen
Journal: Journal of Clinical Investigation (2011)

The p53 tumor suppressor, a central mediator of chemosensitivity in normal cells, is functionally inactivated in many human cancers. Therefore, a central challenge in human cancer therapy is the identification of pathways that control tumor cell survival and chemosensitivity in the absence of functional p53. The p53-related transcription factors p63 and p73 exhibit distinct functions—p73 mediates chemosensitivity while p63 promotes proliferation and cell survival—and are both overexpressed in squamous cell carcinomas (SCCs). However, how p63 and p73 interact functionally and govern the balance between prosurvival and proapoptotic programs in SCC remains elusive. Here, we identify a microRNA-dependent mechanism of p63/p73 crosstalk that regulates p53-independent survival of both human and murine SCC. We first discovered that a subset of p63-regulated microRNAs target p73 for inhibition. One of these, miR-193a-5p, expression of which was repressed by p63, was activated by proapoptotic p73 isoforms in both normal cells and tumor cells in vivo. Chemotherapy caused p63/p73-dependent induction of this microRNA, thereby limiting chemosensitivity due to microRNA-mediated feedback inhibition of p73. Importantly, inhibiting miR-193a interrupted this feedback and thereby suppressed tumor cell viability and induced dramatic chemosensitivity both in vitro and in vivo. Thus, we have identified a direct, microRNA-dependent regulatory circuit mediating inducible chemoresistance, whose inhibition may provide a new therapeutic opportunity in p53-deficient tumors.
Addiction Medicine Specialists Add a New Therapeutic Approach
Authors: Stephen Lurie
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ferritin in the Serum of Normal Subjects and Patients with Iron Deficiency and Iron Overload
Authors: A. Jacobs, F. Miller, M. Worwood, M. R. Beamish, C. A. Wardrop
Journal: BMJ (1972)

The concentration of ferritin in serum gives a quantitative measure of the amount of storage iron in normal subjects and those with iron deficiency or overload. The mean level in normal men is 69 ng/ml, compared with 35 ng/ml in normal women. A concentration below 10 ng/ml is associated with a low transferrin saturation and iron-deficient erythropoiesis.
CASE OF PURPURA HAeMORRHAGICA TREATED BY TURPENTINE
Authors: G. Willis
Journal: BMJ (1854)

IIQM I. O.ONS dications w favourabe, the beat of the heart ws natural, and the air pased fredy throughout both lungs; but the chest movements on the right side.were not quite so fe as en the left.There was nothing that appeaed in the patient'sgeneal condition to forbid the us of chloroform.In accordance with the usual practice for some years past St the Bristol Infirmary, the chloroform was administered to this patient in the ward, previous to her removal into he operating theatre.The patient is transferred from the ward in a narrow wicker basket, containing a small mat- tress, and is easily carried by two persons.The galvanic battery is always kept at hand, in case of accidents.The chloroform of Messrs. Duncan, Flockart, and Co., of Edin- burgh, is that which is employed in the infirmary, and is administered on a cupped porous sponge, care being taken to ensure a due passage of atmospheric air.The patient, Jane Morgan, having taken no food since her breakfast, commenced the inhalation of one drachm of chloreform, on the 21st of January, at 2 P.M., in bed in her ward, under the superintendence of Mr. Hore, the house surgeon.Nothing unusual occurring in the patient's ge- neral condition during inhalation, a second drachm, in about five minutes from the commencement of the first, was poured
Rhymes to Meet Snakes By
Authors: George B. Murray
Journal: JAMA (1988)

<h3>To the Editor.</h3> —Since erroneous identification of the Eastern coral snake was the most common situation resulting in snakebite in Kitchens and Van Mierop's article,<sup>1</sup>an old Boy Scout dictum would have been helpful to the victims. The photographs of the Eastern coral snake and the scarlet king snake were quite helpful, but the dictum, referring to the contiguousness of the colored bands on each snake, is a pearl: "Red and black, friend of Jack [king]/Red and yellow, kill a fellow [coral]."
Dimensions of the ‘Endangered Self’ in Anorexia nervosa
Authors: Klaus Engel, Martina Fuchs, Iris Meier, Fritz Deneke
Journal: Psychotherapy and Psychosomatics (1988)

In addition to the diagnosis of symptoms we recently proposed the empirical analysis of psychodynamic levels; this paper aims at an empirical study of a third, and most essential, problem area: disturbances and/or regulatory processes of the self-system. Based on Deneke's newly developed questionnaire, 30 anorexia nervosa patients were examined, and then compared with 64 normal controls (female university students). A self-profile comprising 18 scales is used to graphically illustrate the disturbances. The primary deficits were found in the subscales of the 'endangered self' and the 'hypochondriac self', while the sub-scales of the 'classic narcissistic self' and the 'idealistic self' were found to be irrelevant. The significant self-system scales were then related to the symptomatology. The conclusion of the paper contains some therapy considerations.
Treatment for benign positional vertigo
Authors: G. M Weiner
Journal: BMJ (1996)

EDITOR,—In their review on benign positional vertigo Thomas Lempert and colleagues place great faith in the histological finding of particulate matter in the posterior semicircular canal,1 although there is a paucity of evidence that such particles are directly implicated in benign positional vertigo. Schuknecht's original observation was based on two postmortem studies.2 …
First Annual Medical Alliance Month Starts Today
Authors: Phil Gunby
Journal: JAMA (1995)

THIS IS the first day of the first annual Medical Alliance Month.  More than 60 000 women and men are active in Medical Alliance programs in connection with local and state medical societies and the American Medical Association (AMA). Medical Alliance is today's name for what most medical associations once called the Medical Auxiliary.  Much of the credit for the month-long observance that begins today, AMA Alliance officials say, goes to Barbara Tippins, the current national president (and wife of an Atlanta, Ga, area obstetrician-gynecologist). Among other goals, this month's effort emphasizes Medical Alliance dedication to public health.  Nationwide Challenges  As Medical Alliance Month gets under way, some 602 alliance initiatives in 36 states are engaged in heightening public awareness of family violence and providing support to its victims.  In addition, more than 2200 alliance programs have begun to address the challenges associated with immunization, tobacco addiction, sex education, teenage
Pressure Curves from the Right Auricle and the Right Ventricle in Chronic Constrictive Pericarditis
Authors: A. TYBJAERG HANSEN, P. ESKILDSEN, H. GÖTZSCHE
Journal: Circulation (1951)

Characteristic patterns of the pressure curves from the right auricle and the right ventricle have been found in chronic constrictive pericarditis by various investigators. It has been uncertain, however, whether or not the findings were pathognomonic, and whether they were reliable pictures of the pressure conditions or artefacts. Consequently the views upon the underlying mechanism have been different too. It is concluded from the studies here presented that the pressure curves are pathognomonic when in their most pronounced form, and that they are not artefacts and thus furnish a proper basis for inferences as to the hemodynamics in chronic constrictive pericarditis.
Secretory function of Barrett's epithelium.
Authors: N B Hershfield, J F Lind, J A Hildes, L S McMorris
Journal: Gut (1965)

A detailed study is recorded of a patient with the oesophagus lined with gastric type epithelium associated with a hiatus hernia, and a benign stricture and peptic ulceration at the level of the aortic arch.Investigations showed that ectopic epithelium was present in biopsies taken along the whole length of the oesophagus and that the motor function of the body of the oesophagus was disordered and the gastro-oesophageal sphincter feeble and incompetent.Biopsies of the mucosa had the typical histological appearance of gastric mucosa, containing both chief cells with pepsinogen granules and parietal cells which responded to histamine stimulation by the secretion of hydrochloric acid.Over a year following these investigations the patient was readmitted and died with a carcinoma of the mid oesophagus.Post-mortem examination showed that the gastriclike mucosa was distributed in islands throughout the entire oesophagus.
Stent Retriever for Dilation of Pancreatic and Bile Duct Strictures
Authors: B. Brand, F. Thonke, S. Obytz, K. F. Binmoeller, V. Rathod, U. Seitz, S. Bohnacker, S. Jäckle, N. Soehendra
Journal: Endoscopy (1999)

Dilation of high grade strictures of pancreatic or biliary ducts using dilating or balloon catheters may fail. We evaluated the efficacy of the 7-Fr Soehendra Stent Retriever used as a dilator.Following sphincterotomy, the stricture was first negotiated with a 260 cm long 0.032-inch J-type Terumo wire. Dilation was then attempted using a 7-Fr dilating catheter. If the stricture could not be traversed, the 7-Fr Stent Retriever was inserted over the Terumo wire to dilate the stricture. Between May 1996 and January 1997, the Stent Retriever was used for dilation in 32 patients with biliary or pancreatic duct strictures.The indication for therapeutic endoscopic retrograde cholangiopancreatography (ERCP) was symptomatic chronic pancreatitis in 21 patients (twelve men, nine women; mean age 45.7, range 26-70). The mean length (+/-SD) of the pancreatic duct strictures was 20mm+/-10 (range 3-55) with a prestenotic ductal diameter of 9mm+/-2 (range 2-15). Out of 21 patients, nine suffered from pancreaticolithiasis and were treated with extracorporeal shock wave lithotripsy. All but three patients underwent successful stenting in the same session. Another 11 patients (four men, seven women; mean age 67.4, range 47-85) had cholestasis because of benign or malignant bile duct strictures. The mean length of the strictures was 20mm+/-5 (range 3-40), and the mean prestenotic diameter was 10mm+/-5 (range 4-21). Stenting was easily done in all of these patients in the same session. Symptom relief was observed within the first week after stenting in all patients with a biliary or pancreatic stricture. In seven cases, material for cytological examination was obtained from the bile duct, which revealed malignancy in two cases. There was no complication associated with the use of the Stent Retriever. One subcapsular liver perforation was caused by the guide wire and occurred prior to the use of the Retriever.Tight pancreatic and bile duct strictures can be dilated successfully with the Stent Retriever. The procedure is of low risk. In addition, tissue sampling is possible in some cases.
On the Production of Articulate Sound (Speech)
Authors: O. Coles
Journal: BMJ (1872)

i8i animal vigour is here meant not so much bodily strength, as its higher representatives-tenacity of purpose, industry and energy.Premature intellectual development is a sign of inferiority.For lower animals are almost born into the fulness of their mind, but it is chiefly automatic mind-instinct.The inferior races of man reach their development, such as it is, earlier, but never arrive at the development of the superior races.Again, precocious children are not those of whom a high kind of mental ability is expected in after years.Their higher qualities ap- proach too much their lower, in the general sense of being more auto-
Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1
Authors: L. W. T. Cheung, K. W. Leung, C. K. C. Wong, R. N. S. Wong, A. S. T. Wong
Journal: Cardiovascular Research (2010)

Ginsenoside-Rg1, the most prevalent active constituent of Panax ginseng, has been shown to possess potent pro-angiogenic properties and therefore poses special interest for the development as a novel modality for angiotherapy. Rg1 can activate the glucocorticoid receptor (GR). However, the mechanism that transmits these pro-angiogenic effects is still unclear. By using human umbilical vein endothelial cells (HUVECs), we show for the first time that in the presence of Rg1, GR and fibroblast growth factor receptor-1 (FGFR-1) cooperate to activate a non-genomic signalling cascade that results in angiogenic activity. The activation of FGFR-1 by Rg1 was blocked by the GR antagonist RU486. Depletion of FGFR-1 expression or inhibition of its activity using small interfering RNA and small molecule inhibitor, respectively, significantly inhibited Rg1-induced phosphatidylinositol 3-kinase/Akt phosphorylation and subsequent endothelial nitric oxide synthase activation and angiogenic tube formation, confirming that the effect was FGFR-1 specific. On exploring how GR might regulate the activation of FGFR-1, we found that GR-mediated FGFR-1 activation was ligand-independent. In addition, we have shown that FGFR-1 regulation by GR was associated with GR/FGFR-1 complex formation. This study provides important new insights into the mechanism regarding the beneficial effects of Rg1 on angiogenesis. We propose that Rg1 could be a novel prototype of nutraceutical that can induce therapeutic angiogenesis.
THE PATHOLOGY OF JOINT TUBERCULOSIS: TUBERCULOUS SINUSES
Authors: LEONARD W. ELY
Journal: JAMA (1910)

In numerous articles in the past I have called attention to the importance of avoiding secondary infection of the walls of tuberculous sinuses and abscesses by the germs of suppuration, and have pointed out the danger the patient incurs if this secondary infection take place. In this I have followed the teachings of others and my own experience, an experience gathered in treating many cases of joint tuberculosis. On the other hand, the custom of opening, scraping and packing tuberculous abscesses is still widespread, and those who practice it do so either from ignorance or because their experience teaches them that it is correct. Now, the experience of one man may be said to be as good as that of another, and until we can bring proof to sustain us we shall hardly convince our opponents. A very suggestive case of tarsal tuberculosis has recently furnished us with additional evidence