tbuckley/cabot-search huggingface dataset:
TRB3 Function in Cardiac Endoplasmic Reticulum Stress
Authors: Joan Avery, Sharon Etzion, Brian J. DeBosch, Xiaohua Jin, Traian S. Lupu, Bassel Beitinjaneh, Jacob Grand, Attila Kovacs, Nandakumar Sambandam, Anthony J. Muslin
Journal: Circulation Research (2010)

Tribbles (TRB)3 is an intracellular pseudokinase that modulates the activity of several signal transduction cascades. TRB3 has been reported to inhibit the activity of Akt protein kinases. TRB3 gene expression is highly regulated in many cell types, and amino acid starvation, hypoxia, or endoplasmic reticulum (ER) stress promotes TRB3 expression in noncardiac cells.The objective of this work was to examine TRB3 expression and function in cultured cardiac myocytes and in mouse heart.Agents that induced ER stress increased TRB3 expression in cultured cardiac myocytes while blocking insulin-stimulated Akt activation in these cells. Knockdown of TRB3 in cultured cardiac myocytes reversed the effects of ER stress on insulin signaling. Experimental myocardial infarction led to increased TRB3 expression in murine heart tissue in the infarct border zone suggesting that ER stress may play a role in pathological cardiac remodeling. Transgenic mice with cardiac-specific overexpression of TRB3 were generated and they exhibited normal contractile function but altered cardiac signal transduction and metabolism with reduced cardiac glucose oxidation rates. Transgenic TRB3 mice were also sensitized to infarct expansion and cardiac myocyte apoptosis in the infarct border zone after myocardial infarction.These results demonstrate that TRB3 induction is a significant aspect of the ER stress response in cardiac myocytes and that TRB3 antagonizes cardiac glucose metabolism and cardiac myocyte survival.
Allergen‐specific immunotherapy in birch‐ and grass‐pollen‐allergic rhinitis. II. Side‐effects
Authors: L. Winther, H.‐J. Malling, H. Mosbech
Journal: Allergy (2000)

Allergen-specific immunotherapy (IT) involves the risk of side-effects. Different side-effect profiles have been reported for different allergens, and it would be of great benefit to be able more precisely to predict patient- and allergen-related risk factors.Fifty-two patients with rhinoconjunctivitis and allergy to birch as well as grass pollen participated in a 3-year IT study, with a baseline year followed by 2 years of treatment. During the first treatment year, the patients received double-blinded IT with either birch (Betula verrucosa) or grass (Phleum pratense) pollen extracts adsorbed to aluminum hydroxide. The following year, the other allergen extract was added. Assessment of systemic reactions (SRs) was performed, and related to patient pretreatment parameters such as seasonal symptoms and medication requirement, skin prick test (SPT), conjunctival provocation test (CPT), nasal provocation test (NPT), total and specific IgE, basophil histamine release (HR), eosinophil count (EOS), eosinophil cationic protein (ECP), and eosinophil protein X (EPX).In total, 44 and 47 patients started IT with birch- and grass-pollen extracts, respectively. All SRs occurred during the dose-increase phase. No life-threatening SRs were observed. There were a higher number of patients with SRs during IT with grass pollen than IT with birch pollen, 21 vs five patients (P<0.001), with SRs to 3.3% of grass-pollen injections compared to 0.7% of birch-pollen injections (P<0.0001). The SRs of birch-pollen IT were mild, consisting of rhinoconjunctivitis and oral-pharyngeal itching, whereas asthma and urticaria episodes were observed in the grass-pollen IT. No difference was found in sensitivity to birch and grass, when measured by SPT, CPT, NPT, specific IgE, or HR, and no difference was found in age, duration of allergic symptoms, prevalence of asthma, mean seasonal birch/grass symptom score, eye-drop use, or antihistamine or prednisolone intake between the group with and without subsequent SRs to IT. No difference was found in EOS, serum ECP, or EPX, between the group with and without subsequent SRs to IT.IT with grass-pollen extract seems to be associated with a higher number and more severe SRs than birch-pollen IT. Neither demographic data nor diagnostic tests of allergy such as specific IgE, HR, SPT, CPT, and NPT could identify the patients with subsequent SRs.
Cultural variations on the SIMS model
Authors: Christine M. Covas-Smith, Justin Fine, Arthur M. Glenberg, Eric Keylor, Yexin Jessica Li, Elizabeth Marsh, Elizabeth A. Osborne, Tamer Soliman, Claire Yee
Journal: Behavioral and Brain Sciences (2010)

Abstract Niedenthal et al. recognize that cultural differences are important when interpreting facial expressions. Nonetheless, many of their core observations derive more from individualistic cultures than from collectivist cultures. We discuss two examples from the latter: (1) lower rates of mutual eye contact, and (2) the ubiquity of specific “functional smiles.” These examples suggest constraints on the assumptions and applicability of the SIMS model.
Radiological damage in patients with rheumatoid arthritis on sustained remission
Authors: G Cohen, L Gossec, M Dougados, A Cantagrel, P Goupille, J. Daures, N Rincheval, B Combe
Journal: Annals of the Rheumatic Diseases (2006)

To assess the radiological damage progression in patients with recent rheumatoid arthritis in sustained remission.A cohort of 191 patients with active early (<1 year) rheumatoid arthritis was prospectively assessed at baseline, 3 and 5 years by the Disease Activity Score (DAS) and the Sharp-van der Heijde Score (SHS) for radiographic damage. Patients in remission (DAS<1.6) at the 3-year and 5-year time points were compared with patients with a persistently active rheumatoid arthritis by Wilcoxon's signed rank test.57 patients died, were lost to follow-up or had incomplete data; 30 (15.7% of those who completed) patients were in remission at 3 and 5 years. The SHS in these two groups was not significantly different at baseline (p = 0.15), but was lower in the remission group at 5 years (p = 0.0047). The median (IQR) radiographic score increased from 0.5 (0-7) at baseline to 2.5 (0-14) after 5 years for the remission group (p = 0.18) and from 2 (0-7) to 13 (3-29) in the group with active rheumatoid arthritis (p<0.001). 5 (16.7%) patients in remission had relevant progression of radiographic damage (ie, progression >4.1 points) and 6 (20%) presented new erosions in a previously unaffected joint between the third and the fifth years.Patients with early rheumatoid arthritis in sustained remission did not present statistically significant radiographic degradation at the group level; nevertheless, 16.7% of these patients did present degradation. Absence of progression should be part of the remission definition in rheumatoid arthritis.
Osseous regeneration in preclinical models using bioabsorbable delivery technology for recombinant human bone morphogenetic protein 2 (rhBMP-2)
Authors: Jennifer L. Smith, Lisa Jin, Thomas Parsons, Thomas Turek, Eyal Ron, C. Michael Philbrook, Richard A. Kenley, Leslie Marden, Jeffrey Hollinger, Mathias P.G. Bostrom, E. Tomin, J.M. Lane
Journal: Journal of Controlled Release (1995)
Amino-acid-based peritoneal dialysis solution improves amino-acid transport into skeletal muscle
Authors: M. Asola, K. Virtanen, K. Någren, S. Helin, M. Taittonen, H. Kastarinen, B. Anderstam, J. Knuuti, K. Metsärinne, P. Nuutila
Journal: Kidney International (2008)
Activation of Nuclear Factor κB <b> <i>In vivo</i> </b> Selectively Protects the Murine Small Intestine against Ionizing Radiation-Induced Damage
Authors: Yong Wang, Aimin Meng, Hainan Lang, Stephen A. Brown, Jennifer L. Konopa, Mark S. Kindy, Richard A. Schmiedt, John S. Thompson, Daohong Zhou
Journal: Cancer Research (2004)

Abstract Exposure of mice to total body irradiation induces nuclear factor κB (NFκB) activation in a tissue-specific manner. In addition to the spleen, lymph nodes, and bone marrow, the tissues that exhibit NFκB activation now include the newly identified site of the intestinal epithelial cells. NFκB activated by total body irradiation mainly consists of NFκB p50/RelA heterodimers, and genetically targeted disruption of the NFκB p50 gene in mice significantly decreased the activation. By comparing tissue damage and lethality in wild-type and NFκB p50 knockout (p50−/−) mice after they were exposed to increasing doses of total body irradiation, we additionally examined the role of NFκB activation in total body irradiation-induced tissue damage. The results show that p50−/− mice are more sensitive to total body irradiation-induced lethality than wild-type mice (LD50/Day 7: wild-type = 13.12 Gy versus p50−/− = 7.75 Gy and LD50/Day 30: wild-type = 9.31 Gy versus p50−/− = 7.81 Gy). The increased radiosensitivity of p50−/− mice was associated with an elevated level of apoptosis in intestinal epithelial cells and decreased survival of the small intestinal crypts compared with wild-type mice (P &amp;lt; 0.01). In addition, RelA/TNFR1-deficient (RelA/TNFR1−/−) mice also exhibited a significant increase in intestinal epithelial cell apoptosis after they were exposed to total body irradiation as compared with TNFR1-deficient (TNFR1−/−) mice (P &amp;lt; 0.01). In contrast, no significant increase in total body irradiation-induced apoptosis or tissue injury was observed in bone marrow cells, spleen lymphocytes, and the liver, heart, lung, and kidney of p50−/− mice in comparison with wild-type mice. These findings indicate that activation of NFκB selectively protects the small intestine against ionizing radiation-induced damage.
Abstract LB-184: Identification of breast cancer susceptibility genes using whole exome sequencing
Authors: Ella Thompson, Jason Ellul, Jason Li, Maria Doyle, Ian Campbell
Journal: Cancer Research (2010)

Abstract Discussion Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-184.
THE CHILD WHO REFUSES TO ATTEND SCHOOL
Authors: T. P. MILLAR
Journal: American Journal of Psychiatry (1961)

School refusal would seem to be a symptom complex appearing in more than one psychological configuration. In its acute form, it is felt to arise out of difficulties that the child has experienced in achieving a sense of autonomy. This has been due primarily to fluctuant limit setting by over involved parents. Direct management of the situation to control the symptom is essential to restore the child to normal growth patterns. Since symptom displacement and recurrence are not common it is suggested that the symptom in its acute form is more situational in character than indicative of a structured neurotic illness.
Re-entrant ventricular arrhythmias in the late myocardial infarction period. 3. Manifest and concealed extrasystolic grouping.
Authors: N El-Sherif, R Lazzara, R R Hope, B J Scherlag
Journal: Circulation (1977)

Re-entrant beats with regular extrasystolic grouping were seen in 44- of dogs 3--7 days following ligation of the anterior descending coronary artery. Utilizing direct recording of the re-entrant pathway (RP) from the epicardial surface of the infarction zone, we found extrasystolic grouping to be based on the infarction tachycardia-dependent conduction disorders in a potentially RP. Trigeminy and quadrigeminy were related, respectively, to a 3:2 and 4:3 Wenckebach-like conduction cycle in a RP. However, quadrigeminy could also be due to an underlying bigeminal rhythm with concealment of alternate re-entrant beats, i.e., concealed bigeminy. A bigeminal rhythm was the result of a 2:1 conduction pattern in a re-entrant pathway with a sufficient degree of conduction delay during the conducted beat of the 2:1 cycle to result in re-entry. A trigeminal or quadrigeminal rhythm could change to a bigeminal rhythm on critical shortening of the cardiac cycle. Fixed and variable coupling were related, respectively, to stable and changing conduction pattern in a re-entrant pathway. On the other hand, extrasystolic grouping could be concealed due to either block in the re-entrant pathway or entrapment in a small area of the closely bordering normal zone.
The VA Advantage for Appropriate TAVR Use
Authors: Rosemary F. Kelly, Karol Mudy
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
THE WOUNDED OF THE PORTO RICAN CAMPAIGN.
Authors: N. SENN
Journal: JAMA (1898)

The Cuban and Porto Rican invasions have confirmed the experience of the past in showing that the greatest horrors of war are caused by disease and its consequences rather than the implements of destruction. If the battle-grounds are in the extreme north or south, climate enters as an important factor in decimating the ranks and in increasing the sufferings of the contending armies. A war of invasion requires more preparation, foresight and forethought on the part of those who plan and conduct the campaign than one of defense, a fact we have been painfully made aware of during the last two months. The more remote the seat of conflict, the more difficult the task of providing food and clothing for the army, and the more serious becomes the problem of properly caring for the sick and wounded, and the greater becomes the difficulty in returning the survivors to their homes.
730-6 Histopathologic Findings in Ostial Coronary Lesions Treated with Directional Atherectomy
Authors: Jonathan D. Bier, Sunit Mukherjee, Ramin Ebrahimi, Andrew P. Chados, David Gagnon, Kathleen Horton, Alice K. Jacobs
Journal: Journal of the American College of Cardiology (1995)
A Family Study of Child Abuse
Authors: LENORE C. TERR
Journal: American Journal of Psychiatry (1970)

Ten battered children and their families were evaluated by the author over a six-year period. It was found that important factors leading to abuse were fantasies of the abuser about the child, exaggerated dominant-submissive patterns in the marriage, and contributions of the child to the battering. The author offers several suggestions for using a family approach in treating battered children.
The Relationship of Renal Blood Flow to Cardiac Output in Normal Individuals as Determined by Concomitant Radioisotopic Measurements
Authors: R. E. Botti, M. A. Razzak, W. J. MacIntyre, W. H. Pritchard
Journal: Cardiovascular Research (1968)

Renal blood flow and cardiac output were determined in normal men using single injection radioisotopic techniques. These methods use external monitoring to obviate the discomforts and difficult chemical determinations of older methods. The average cardiac index of 3·36 ± 0·35 l./min/m2 and the average renal blood flow of 629 ± 70·0 ml./min/m2 compare favourably with previously reported values.
Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis
Authors: E Anyukhovsky
Journal: Cardiovascular Research (2002)

Objective: The incidence of atrial fibrillation increases with age. We hypothesized that aging-associated changes in the atrial action potential (AP) and conduction velocity provide a substrate for abnormal conduction and arrhythmogenesis. Methods: We used microelectrode techniques to record AP from the endocardium of the right atrial wall of dogs aged 1–5 (adult) and >8 years (old). Conduction velocity was measured between two microelectrodes 3–10 mm apart. Histological study was carried out to assess fibrosis. Results: Whereas resting potential, AP amplitude and Vmax did not differ with age, the plateau was more negative and AP duration was longer in old tissue. The L-type calcium current (ICa,L) agonist Bay K8644 (10−8–10−6 mol/l) elevated the plateau and shortened APD more in old than in adult, such that AP contour in old atria approached that of adult. In contrast, the ICa,L blocker nisoldipine (10−8–10−5 mol/l) depressed the plateau in adult and had no effect in old. There was no difference between the two groups in conduction velocity of normal beats, whereas for early premature impulses, reduced conduction velocity and a wider time window manifesting slow conduction were detected in old in comparison to adult tissue. A twofold increase in the amount of fibrous tissue was detected in old atria. Conclusions: Our data show significant differences in contour of AP in adult and old atria. The responses to Bay K8644 and nisoldipine suggest a decreased ICa,L in old atrial tissue. The alterations in AP contour and increased fibrosis may be responsible for slower conduction of early premature beats in old atria. The age-related changes in conduction of premature beats are consistent with those observed in patients with paroxysmal atrial fibrillation and may contribute to the greater propensity to atrial fibrillation in the aged.
Bioconversion of C-6 Sulfidopeptide Leukotrienes by the Responding Guinea Pig Ileum Determines the Time Course of its Contraction
Authors: Steven Krilis, Robert A. Lewis, E. J. Corey, K. Frank Austen
Journal: Journal of Clinical Investigation (1983)

The naturally occurring sulfidopeptide leukotrienes, leukotriene (LT) C4 (LTC4) [5(S)-hydroxy - 6(R) - S - glutathionyl - 7,9 - trans, 11,14 - cis - eicosatetraenoic acid] and its cysteinylglycine (LTD4) and cysteinyl (LTE4) analogs, which are derived by peptide cleavage, differ in the concentrations required to elicit comparable contractions of the guinea pig ileum, with respective potencies of 1.2:5:1. The effect of the ongoing bioconversion of LTC4 and LTD4 on the contractile response of the guinea pig ileum to each was determined by recording the pattern of the contraction and quantitating the initial agonist and its metabolic products. The contraction was elicited by radiolabeled agonist, and its conversion products were sampled at defined intervals and resolved by their retention times on reverse-phase high performance liquid chromatography. After a latent period of 60 s. LTC4 initiated a linear response, followed by a slower, progressive response to a maximum level that was maintained without relaxation. The metabolic conversion of LTC4 was <5% during the linear phase of contraction and complete inhibition of bioconversion of LTC4 to LTD4 by the presence of serine-borate complex did not alter the pattern of the spasmogenic response. As the maximum response in the presence of serine-borate complex was three-quarters of that obtained without the inhibitor of bioconversion, the predominant response was to LTC4 itself. The spasmogenic response of the ileum to LTD4 was immediate, linear to a maximum level, and immediately followed by a marked relaxation. That the failure of LTD4 to sustain a contraction was due to its immediate, rapid, and quantitative conversion to the less potent LTE4 was established by pharmacologically inhibiting and anatomically deleting the converting activity. In the presence of L-cysteine the conversion of LTD4 to LTE4 was largely inhibited and the maximum contractile response was well maintained. After anatomic removal of the mucosa that contained the LTD4 dipeptidase activity, the longitudinal smooth muscle preparation gave a maximal response to LTD4 that was fully maintained. Thus, bioconversion is not a prerequisite for the spasmogenic activity of LTC4 and accounts for the transient response of the ileum to LTD4.
Voltage dependence of intracellular [Ca2+]i transients in guinea pig ventricular myocytes.
Authors: L Barcenas-Ruiz, W G Wier
Journal: Circulation Research (1987)

[Ca2+]i transients, elicited by voltage-clamp depolarization of single guinea pig cardiac ventricular cells, were observed through use of the fluorescent Ca2+ indicator, fura-2. Individual cells, loaded with fura-2 either by internal perfusion or by exposure to fura-2/AM, were studied with the use of an inverted microscope that was equipped with ultraviolet epifluorescence illumination, an intensified silicon intensifier target camera, and a photomultiplier tube. Variation of membrane voltage and exposure of cells to verapamil (a Ca2+ channel blocker) and ryanodine (which was assumed to abolish selectively the release of Ca2+ from the sarcoplasmic reticulum) were used to investigate the cellular processes that determine the [Ca2+]i transient. The principal results of the study are: When appropriate methods are used, the properties of cytosolic fura-2 inside guinea pig cells are similar to those of fura-2 in solution, irrespective of the method of loading. The amplitude (at 100 msec) of verapamil-sensitive fluorescence transients elicited by pulse depolarization (range -30 to 80 mV) has a bell-shaped dependence on membrane voltage (maximum at 10 mV). Rapid, ryanodine-sensitive and verapamil-sensitive "tail transients" are elicited on repolarization from membrane potentials greater than 30 mV; their amplitude increases as the amplitude of the preceding pulse increases. The amplitude of slow fluorescence transients that are insensitive to verapamil and ryanodine increases continuously with membrane potential throughout the range -20 to 80 mV. The voltage dependence and pharmacology of the rapid transients elicited by pulse depolarization or by repolarization are consistent with their having arisen from Ca2+ released from the sarcoplasmic reticulum, via Ca2+-induced Ca2+ release.(ABSTRACT TRUNCATED AT 250 WORDS)
A Silent Follicle-Stimulating Hormone-Producing Pituitary Adenoma in a Teenage Male
Authors: Hiroyuki Tamiya, Noriaki Fukuhara, Naohiro Yoshida, Hisanori Suzuki, Akira Takeshita, Naoko Inoshita, Hiroshi Nishioka, Yasuhiro Takeuchi, Toshiaki Sano, Shozo Yamada
Journal: Endocrine Pathology (2011)
Haematuria in rheumatoid arthritis: a follow up study.
Authors: C A Kelly, P Mooney, L D Hordon, I D Griffiths
Journal: Annals of the Rheumatic Diseases (1988)

Twenty one patients with seropositive rheumatoid arthritis and previously documented isolated haematuria were recalled at a median 7.7 years (range 3-12) after initial investigation. Eighteen subjects had previously undergone renal biopsy, which had shown mesangial glomerulonephritis in all but four cases. Renal function was found to have remained normal in all patients with previous mesangial changes despite the presence of persistent haematuria in most cases.
CARCINOMA OF THE LUNG OF LONG DURATION
Authors: ALFRED GOLDMAN
Journal: JAMA (1942)

Hardly a series of cases of carcinoma of the lung has been reported without mention of some cases in which the duration was two years or more. In Brunn's<sup>1</sup>series (1926) there were 20, or 7.5 per cent, of cases in which the disease had such a duration. In the reports published before 1932<sup>2</sup>it is unlikely that adenoma was differentiated from carcinoma. It seemed advisable to review our cancer material to determine whether, exclusive of possible adenoma, cancer of long duration existed. Eleven cases of cancer of a duration of more than two years, proved histologically, were encountered and studied. In the course of the study certain data were discovered which may be a clue to earlier recognition of some types of carcinoma. The age distribution of the patients was not remarkable, the ages ranging from 40 to 70. But wider variations are found in larger series.