tbuckley/cabot-search huggingface dataset:
Antibody to very late activation antigen 4 prevents antigen-induced bronchial hyperreactivity and cellular infiltration in the guinea pig airways.
Authors: M Pretolani, C Ruffié, J R Lapa e Silva, D Joseph, R R Lobb, B B Vargaftig
Journal: The Journal of Experimental Medicine (1994)

This report examines the effect of an anti-VLA-4 monoclonal antibody (mAb) HP1/2 on antigen-induced bronchial hyperreactivity to methacholine, and on eosinophil and T lymphocyte infiltration in the airways of guinea pigs sensitized and challenged by aerosolized ovalbumin and used 24 h thereafter. The intravenous administration of 2.5 mg/kg of HP1/2, but not of its isotype-matched mAb 1E6, 1 h before and 4 h after antigen inhalation, markedly inhibited the increased bronchopulmonary responses to intravenous methacholine, as well as airway eosinophilia in bronchoalveolar lavage (BAL) fluid and in bronchial tissue. HP1/2 also suppressed the antigen-induced infiltration of the bronchial wall by CD4+ and CD8+ T lymphocytes, identified by immunohistochemical technique using specific mAbs that recognize antigenic epitopes of guinea pig T cells. Treatment with HP1/2 also resulted in a significant increase in the number of blood eosinophils, suggesting that inhibition by anti-VLA-4 mAb of eosinophil recruitment to the alveolar compartment may partially account for their accumulation in the circulation. These findings indicate that eosinophil and lymphocyte adhesion and subsequent infiltration into the guinea pig airways that follow antigen challenge are mediated by VLA-4. Furthermore, concomitant inhibition of antigen-induced bronchial hyperreactivity and of cellular infiltration by anti-VLA-4 mAb suggests a relationship between airway inflammation and modifications in the bronchopulmonary function.
Zotarolimus-Eluting Versus Bare-Metal Stents in Uncertain Drug-Eluting Stent Candidates
Authors: Marco Valgimigli, Athanasios Patialiakas, Attila Thury, Eugene McFadden, Salvatore Colangelo, Gianluca Campo, Matteo Tebaldi, Imre Ungi, Stefano Tondi, Marco Roffi, Alberto Menozzi, Nicoletta de Cesare, Roberto Garbo, Emanuele Meliga, Luca Testa, Henrique Mesquita Gabriel, Flavio Airoldi, Marco Ferlini, Francesco Liistro, Antonio Dellavalle, Pascal Vranckx, Carlo Briguori
Journal: Journal of the American College of Cardiology (2015)
Retraction of Article From ACP Journal Club
Authors: R. Brian Haynes
Journal: Annals of Internal Medicine (2009)

Retractions15 December 2009Retraction of Article From ACP Journal ClubFREEThis retraction concerns the following article:TherapeuticsSep 2003Combination ACE inhbitor and angiotensin-receptor blocker therapy was better than monotherapy in nondiabetic renal diseaseWolfgang J. Weise, MDWolfgang J. Weise, MDUniversity of Vermont, Burlington, Vermont, USA (W.J.W.)Search for more papers by this authorR. Brian Haynes, MD, PhDR. Brian Haynes, MD, PhDEditor, ACP Journal Club Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-12-200912150-00022 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A report of the COOPERATE trial (1) was abstracted in the September/October 2003 issue of ACP Journal Club(2). Lancet has now issued a retraction of the original article (3); as such, the abstract and commentary published in ACP Journal Club are also retracted.R. Brian Haynes, MD, PhDEditor, ACP Journal ClubReferences1. Nakao N, Yoshimura A, Morita H, Takada M, Kayano T, Ideura T. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet. 2003;361:117-24. [PMID: 12531578] CrossrefMedlineGoogle Scholar2. Combination ACE inhibitor and angiotensin-receptor blocker therapy was better than monotherapy in nondiabetic renal disease [Abstract]. ACP J Club. 2003;139(2):40. Abstract of: Nakao N, Yoshimura A, Morita H, et al. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet. 2003;361:117-24. Google Scholar3. Retraction—Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet. 2009;374:1226. [PMID: 19819378] CrossrefMedlineGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Editor, ACP Journal Club PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCombination ACE inhbitor and angiotensin-receptor blocker therapy was better than monotherapy in nondiabetic renal disease Wolfgang J. Weise Metrics 15 December 2009Volume 151, Issue 12Page: 897 ePublished: 15 December 2009 Issue Published: 15 December 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
MODERN TREATMENT OF TUBERCULOSIS.
Authors: CHARLES DENISON
Journal: JAMA (1898)

I am requested by our Chairman to formulate the theories and conclusions on the modern treatment of tuberculosis. The object is to bring out your thoughts and excite discussion, and I trust I shall not fail in this purpose. As there are no two cases of tuberculosis in a thousand alike in all their various phases, so I might almost say there are no two physicians who will treat these manifestations in the same way, even if they are all recognized, which is a question. Our mental appreciation of this most important of the diseases which afflict the human race is in a formative state. I fancy one would only have to announce a set plan of management, which he would carry out as suitable to the great majority of his own patients, and the desired controversy would at once be set in motion in opposition thereto. Taking 100 per
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis
Authors: Olivier Gribouval, Marie Gonzales, Thomas Neuhaus, Jacqueline Aziza, Eric Bieth, Nicole Laurent, Jean Marie Bouton, François Feuillet, Saloua Makni, Hatem Ben Amar, Guido Laube, Anne-Lise Delezoide, Raymonde Bouvier, Frédérique Dijoud, Elisabeth Ollagnon-Roman, Joelle Roume, Madeleine Joubert, Corinne Antignac, Marie Claire Gubler
Journal: Nature Genetics (2005)
Points from Letters: Traffic Signs for the Colour-blind
Authors: J. W. Pickard
Journal: BMJ (1964)

feather-bedded " with tax allowances and incentives the struggles of the G.P.s to improve their existing surgeries or build new ones with discouragement at every turn is one of the iniquities of the present day.Now that we are no longer members of a "fee-raising " profession, if our masters call the tune they must pay the piper in full.
Ethics. Research, and Animal Welfare
Authors: M. B. Visscher
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I welcome the opportunity presented by Kurtz' letter to clarify further the realities of the controversy over special administrative legislation governing animal experimentation. The proposed legislation which Kurtz apparently defends would state as a national policy that vertebrate animals should be employed in medical and other biological studies "only when no other feasible and satisfactory methods can be used to ascertain biological and scientific information." It would also make it very difficult or even impossible for such animals to be used in any undergraduate teaching program. The assertions by Kurtz of the "well-documented examples of abuse of laboratory animals" can be disputed on factual grounds. In the congressional hearings there were actually no "documented" examples of abuses presented whatever, if for documentation, one requires anything more than unproven assertions. It may interest readers ofThe Journalto know that, despite the furore over pet-napping for sale to
For patients' sake, don't boycott e-health records
Authors: Marlene Winfield
Journal: BMJ (2007)

Can I be the only patient scratching my head about the BMA's decision to advise general practitioners to boycott the creation of summary care records for their patients? The new record has two main purposes: to provide the NHS with crucial patient information when none is available from other sources, and to give people themselves access to a good summary of their health records whenever they need it.

For me as a patient this means that anyone I ask to help me at evenings and weekends will know basic information about me. This is particularly important now that GPs no longer provide their own out of hours cover for us. Unfortunately, I find that I usually develop a raging urinary tract infection on a Friday night and it would be really helpful for the stranger I ring to know what antibiotics worked for me before, which one caused me to come out in a …
What's in a Name? That Depends...
Authors: Lester Adelson
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Because I suffer from chronic nitpickophilia with frequent acute exacerbations, I am impelled to call attention to a misnomer for a tragic situation. The "café coronary," so thoughtfully and lucidly presented and discussed by Mittleman and Wetli (1982;247:1285), occurs, as their data indicate, most often in a locale other than a public eating place (café). Indeed, more of these catastrophes take place in the home than in any other site. Accordingly, I believe that a more appropriate (and accurate) group appellation for this occurrence is a "culinary coronary." This entity can then be broken down into "kitchen coronary," "café coronary," and "cafeteria coronary," depending on the precise location of the incident. These three phrases retain the built-in benefit of "apt alliteration's artful aid," although admittedly this is true only phonetically of the "kitchen" variety.
FOUR DEATHS ASSOCIATED WITH CHLORPROMAZINE
Authors: ROBIE T. CHILDERS
Journal: American Journal of Psychiatry (1962)

Four deaths associated and presumably linked with the administration of chlorpromazine is presented. Although the phenothiazines, which have so changed the outlook for psychiatric patients, can usually be administered with only the occurrence of minor side effects, we must always be alert to the possibility of serious side effects. Early recognition and proper treatment should materially reduce. the mortality.
ADDRESS IN SURGERY.At the Annual Meeting of the American Medical Association, Detroit. June. 1892. THE GENERAL PRINCIPLES OF THE SURGERY OF THE HUMAN BRAIN AND ITS ENVELOPES.
Authors: JOHN B. HAMILTON
Journal: JAMA (1892)

Mr. President and Gentlemen:—The duty of delivering the annual address in surgery, has this year been assigned to me, and while I deeply appreciate the honor, it was with a profound sense of the difficulties of the task, that I accepted it. The founders of the plan of general addresses no doubt intended that each address should constitute an annual review of the whole subject assigned. But at this date, the time at the disposal of your orator will not permit it, and for the past few years the custom has been, to select some particular division of the subject as the topic for the discussion. My topic on this occasion will be: "The General Principles of the Surgery of the Human Brain and its Envelopes." "On earth there is nothing great but man, In man there is nothing great but mind." The diseases and injuries of the seat of
Microtubule-Associated Proteins as Targets in Cancer Chemotherapy
Authors: Kumar M.R. Bhat, Vijayasaradhi Setaluri
Journal: Clinical Cancer Research (2007)

Abstract Natural and synthetic compounds that disrupt microtubule dynamics are among the most successful and widely used cancer chemotherapeutic agents. However, lack of reliable markers that predict sensitivity of cancers to these agents and development of resistance remain vexing issues. There is accumulating evidence that a family of cellular proteins that are associated with and alter the dynamics of microtubules can determine sensitivity of cancer cells to microtubule-targeting agents and play a role in tumor cell resistance to these agents. This growing family of microtubule-associated proteins (MAP) includes products of oncogenes, tumor suppressors, and apoptosis regulators, suggesting that alteration of microtubule dynamics may be one of the critical events in tumorigenesis and tumor progression. The objective of this review is to integrate the knowledge on these seemingly unrelated proteins that share a common function and examine their relevance to microtubule-targeting therapies and highlight MAPs-tubulin-drug interactions as a novel avenue for new drug discovery. Based on the available evidence, we propose that rational microtubule-targeting cancer therapeutic approaches should ideally include proteomic profiling of tumor MAPs before administration of microtubule-stabilizing/destabilizing agents preferentially in combination with agents that modulate the expression of relevant MAPs.
High Incidence of Gastric Reflux During Hepatobiliary Imaging in Pancreatitis
Authors: JAMES D. SLAVIN, JOSEPH J. SKARZYNSKI, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1985)

A review of 100 consecutive hepatobiliary studies revealed eight cases in which there was prominent gastric reflux of the Tc-99m diisopropyl-IDA beginning 0.5 to 2.0 hours into the procedure. Five of these individuals had pancreatitis (four acute, one chronic). Hence, pancreatitis was involved in five out of eight of the studies with marked gastric reflux. A study of discharge records showed that a total of ten of the patients in this series had pancreatitis. Since only five showed prominent gastric reflux, the incidence was 50%. Other disorders accounted for the three remaining gastric reflux cases observed in 90 patients.
Identifying Optimal Candidates for Local Treatment of the Primary Tumor Among Patients Diagnosed with Metastatic Prostate Cancer: A SEER-based Study
Authors: Nicola Fossati, Quoc-Dien Trinh, Jesse Sammon, Akshay Sood, Alessandro Larcher, Maxine Sun, Pierre Karakiewicz, Giorgio Guazzoni, Francesco Montorsi, Alberto Briganti, Mani Menon, Firas Abdollah
Journal: European Urology (2014)
Improving drug compliance after hospital discharge.
Authors: E T MacDonald, J B MacDonald, M Phoenix
Journal: BMJ (1977)

The effect of counselling on medication errors was assessed in 165 elderly patients after leaving hospital. Counselling was effective, with counselled patients making under one-third of the errors made by uncounselled patients. Three types of memory aid were tried to supplement counselling. The pill wheel increased errors, a tablet identification card was unhelpful, and only a tear-off daily calendar seemed to improve results modestly. Counselling was virtually as effective in improving compliance in poorly orientated patients. A designated member of staff should spend about 15 minutes with each elderly patient before discharge to ensure that the discharge drug regimen is fully understood and remembered, that old tablets are destroyed and that other people9s tablets are not taken.
Attractive Method for Battery Removal
Authors: Gregory L. Landry
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We appreciated the article by Kavanagh and Litovitz<sup>1</sup>entitled "Miniature Battery Foreign Bodies in Auditory and Nasal Cavities." We would like to add the use of a magnet to the list of possible battery retrieval methods. Use of a magnet to remove batteries from the stomach has been described,<sup>2</sup>but, to our knowledge, a magnet has not been used for removal of batteries from other orifices. A magnetized screwdriver worked very well in the following case. <h3>Report of a Case.—</h3> A 9-year-old girl awoke with acute otalgia in the left ear immediately after her 5-year-old play-mate inserted a miniature toy watch battery in her ear canal. Her intense pain continued and she was examined in our clinic about 90 minutes after the incident. The battery was lodged mid-way in the canal and efforts to retrieve the battery with alligator forceps were unsuccessful and painful. After
Infection With <i>Chlamydia pneumoniae</i> Accelerates the Development of Atherosclerosis and Treatment With Azithromycin Prevents It in a Rabbit Model
Authors: Joseph B. Muhlestein, Jeffrey L. Anderson, Elizabeth H. Hammond, Liping Zhao, Sanjeev Trehan, Eric P. Schwobe, John F. Carlquist
Journal: Circulation (1998)

Background — Chlamydia pneumoniae infection has been associated with atherosclerosis by serological studies and detection of bacterial antigen within plaque. We sought to evaluate a possible causal role in an animal model. Methods and Results —Thirty New Zealand White rabbits were given three separate intranasal inoculations of either C pneumoniae (n=20) or saline (n=10) at 3-week intervals and fed chow enriched with a small amount (0.25%) of cholesterol. Immediately after the final inoculation, infected and control rabbits were randomized and begun on a 7-week course of azithromycin or no therapy. Three months after the final inoculation, rabbits were euthanatized and sections of thoracic aortas were blindly evaluated microscopically for maximal intimal thickness (MIT), percentage of luminal circumference involved (PLCI), and plaque area index (PAI) of atherosclerosis. Vascular chlamydial antigen was assessed by direct immunofluorescence. MIT differed among treatment groups ( P =.009), showing an increase in infected rabbits (0.55 mm; SE=0.15 mm) compared with uninfected controls (0.16 mm; SE=0.06 mm) and with infected rabbits receiving antibiotics (0.20 mm; SE=0.03 mm) (both P &lt;.025), whereas MIT in infected/treated versus control rabbits did not differ. PLCI also tended to differ ( P &lt;.1) and PAI differed significantly ( P &lt;.01) among groups with a similar pattern. Chlamydial antigen was detected in 2 untreated, 3 treated, and 0 control animals. Conclusions —Intranasal C pneumoniae infection accelerates intimal thickening in rabbits given a modestly cholesterol-enhanced diet. In addition, weekly treatment with azithromycin after infectious exposure prevents accelerated intimal thickening. These findings strengthen the etiologic link between C pneumoniae and atherosclerosis and should stimulate additional animal and human studies, including clinical antibiotic trials.
Substantial reduction in defibrillation thresholds in dogs using a one capacitor dual biphasic waveform and multielectrode nonthoracotomy lead configurations
Authors: Paul A. Guse, Clif A. Alferness, Katherine M. Kavanagh, Patrick D. Wolf, Dennis L. Rollins, Jenny A. Hagler, Sharon B. Melnick, Raymond E. Ideker
Journal: Journal of the American College of Cardiology (1991)
Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire
Authors: W. V. Bonilla
Journal: Journal of Clinical Investigation (2005)

Rare cases of stable allograft acceptance after discontinuation of immunosuppression are often accompanied by macrochimerism (> 1% donor cells in blood) or microchimerism (< 1% donor cells in blood). Here, we have investigated whether persistence of donor cells is the cause or the consequence of long-lasting CTL unresponsiveness. We found that engraftment of splenocytes bearing a single foreign MHC class I–restricted epitope resulted in lifelong donor cell microchimerism and specific CTL unresponsiveness. This status was reversed in a strictly time- and thymus-dependent fashion when the engrafted cells were experimentally removed. The results presented herein show that microchimerism actively maintains CTL unresponsiveness toward a minor histocompatibility antigen by deleting the specific repertoire and thus excluding dominant, T cell extrinsic mechanisms of CTL unresponsiveness independent of systemically persisting donor cell antigen.
Correlations between human skin bacteria and skin lipids
Authors: J.N. KEARNEY, EILEEN INGHAM, W.J. CUNLIFFE, K. T. HOLLAND
Journal: British Journal of Dermatology (2006)

Correlation matrices were constructed for various human skin variables (propionibacteria, micrococcaceae, sebum excretion rate, percentage of free fatty acids and free fatty acid production rate). Two independent populations were studied (n = 87 and n = 103), and a subpopulation (n = 30) was investigated on three occasions at intervals of I month. In this way consistently high correlations could be differentiated from 'fortuitous' correlations. Propionibacteria versus micrococcaceae showed the highest correlation coefficient and propionibacteria versus percentage free fatty acids was also highly correlated. A scatter diagram indicated a relationship between the lower threshold of microbial density and sebum excretion rate. An explanation based on relative duct and gland size is presented.
Enveloped Viruses Disable Innate Immune Responses in Dendritic Cells by Direct Activation of TAM Receptors
Authors: Suchita Bhattacharyya, Anna Zagórska, Erin D. Lew, Bimmi Shrestha, Carla V. Rothlin, John Naughton, Michael S. Diamond, Greg Lemke, John A.T. Young
Journal: Cell Host & Microbe (2013)
Cancer group denies company funding will influence its agenda
Authors: Rory Watson
Journal: BMJ (2006)

The organisers of a pan-European cancer campaign have denied claims that they are in the pocket of the drug industry. The new organisation, Cancer United (http://www.cancerunited.org/), has received funding from Roche, the world's leading maker of anticancer drugs. The public relations firm Weber Shandwick is providing logistical support.

John Smyth, Cancer United's chairman, who is professor of medical oncology in Edinburgh and also the president of the Federation of European Cancer Societies, said that he had approached Roche …
Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients
Authors: Giovanni Targher, Lorenzo Bertolini, Christopher Day
Journal: Diabetes Care (2007)

We appreciate the comments by Schindhelm et al. (1) regarding our recent article reporting the prevalence of nonalcoholic fatty liver disease (NAFLD) and its association with cardiovascular disease (CVD) in a type 2 diabetic population (2). In that study, we found that NAFLD is extremely common in type 2 diabetes and is associated with a higher frequency of manifest CVD. The prevalence of NAFLD was 69.5% among participants, and NAFLD was the most common cause (81.5%) of hepatic steatosis on ultrasound. In contrast, the frequency of hepatic steatosis likely due to other nonalcoholic …