tbuckley/cabot-search huggingface dataset:
LOW-DOSE MONOCLONAL ANTIBODY IMAGING OF NUDE MICE BEARING CEA-SECRETING XENOGRAFTS
Authors: Lawrence E. Williams, James G. Jakowatz, Raymond J. Paxton, David Porudominsky, Brian R. Clark, Barbara G. Beatty, William G. Vlahos, John E. Shively, J. David Beatty
Journal: Clinical Nuclear Medicine (1984)

Biodistributions and images of a monoclonal antibody (MoAb) to carcinoembryonic antigen (CEA) were obtained in a nude mouse model bearing the LS174T human tumor. The MoAb (T84,66), labeled with In-111 using a bi-functional chelate, was initially screened against human blood and liver cells and showed no cross-reactivity. Three levels of this IgG protein were used: 62.5, 625 and 6250 ngm per animal. Specific activity was 50 nCi/ngm. Percent injected dose per gram of tissue (% ID/gm) at 48 h post IV injection of the anti-CEA MoAb was as follows (mean ± SEM): 62.5 625 6250 ngm LS174T 7.0 ± 0.B 11.6 ± 1.8 35.0 ± 6.2 Blood 0.8 ± 0.1 1.3 ± 0.3 6.4 ± 1.4 Liver 5.7 ± 0.7 5.7 ± 0.6 13.3 ± 1.5 Imaging at even the 62.5 ngm level revealed the tumor as a distinct focus of activity. A control experiment using 62.5 ngm of anti-P450 MoAb yielded a LS174T uptake of 6.5 ± 0.5 % ID/gm (48 h), but with a tumor/blood ratio (T/B) of only 0.62 as compared to 8.8 for the anti-CEA. A second control with anti-CEA against EMT6 tumor resulted in tumor uptake of 2.4 ± 0.3 % ID/gm and T/B = 1.4. We conclude that an injection of 62.5 ngm of T84.66 MoAb provides useful imaging of CEA-secreting tumors in the nude mouse. This amount of protein is, on a per-kilogram basis, equivalent to approximately 200μgm for an adult human. Such a low dose would probably permit serial clinical studies without immune system response to the T84.66 murine antibody.
In Vivo Imaging of C. elegans Mechanosensory Neurons Demonstrates a Specific Role for the MEC-4 Channel in the Process of Gentle Touch Sensation
Authors: Hiroshi Suzuki, Rex Kerr, Laura Bianchi, Christian Frøkjær-Jensen, Dan Slone, Jian Xue, Beate Gerstbrein, Monica Driscoll, William R Schafer
Journal: Neuron (2003)
Failure of Glucagon Release in Infants of Diabetic Mothers
Authors: S. R. Bloom, D. I. Johnston
Journal: BMJ (1972)

Two hours after birth 30 normal infants had a fall in blood glucose of 20.6 mg/100 ml and a rise of plasma pancreatic glucagon of 50.7 pg/ml. Fifteen infants of diabetic mothers treated with insulin had a much greater fall in blood glucose of 77.5 mg/100 ml and a smaller rise of glucagon of 20.9 pg/ml. By comparison 14 small-for-dates infants, who are also prone to hypoglycaemia, had a blood glucose fall of 32.8 mg/100 ml and a larger rise of pancreatic glucagon of 96.0 pg/ml. It is suggested that the impaired pancreatic glucagon rise in the infants of diabetic mothers may be a significant factor in their hypoglycaemia.
THOUGHTS ON THE RELATION OF PHYSIOLOGY TO PSYCHOLOGY
Authors: Thomas Hun
Journal: American Journal of Psychiatry (1846)

ter, and of their relations, constitutes physical science, or rather the physical sciences, for there are several.The divisions of the physical sciences depend on the differences in the properties and phenomena of the objects of nature, and on the impossibility of reducing them to one general principle.Thus, we find in living beings, phenomena which are dtlThrent from those of dead matter, and it is impossible to reduce the one into the other, by any means of analyzing
Points from Letters: Review Body Report
Authors: C. H. Neaves
Journal: BMJ (1974)

some extent those retiring between 1969 and 1972 will be given less than their olleagues who retired after 24 March 1972.This means that there has to be for them a different formula from that for general practitioners retiring after 24 March 1972 and it is on this that there have been some-what protracted negotiations with the De- partment.We have certainly put every pressure on the Department to expedite matters and we hope that with the help of our professional expert advisers we -may be able to reach an early settlement."-ED.,
Prolonged Continuous Infusion of Fluorouracil With Weekly Bolus Leucovorin: A Phase II Study in Patients With Disseminated Colorectal Cancer
Authors: C. G. Leichman, L. Leichman, C. P. Spears, P. J. Rosen, S. Jeffers, S. Groshen
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Prolonged Continuous Infusion of Fluorouracil With Weekly Bolus Leucovorin: A Phase II Study in Patients With Disseminated Colorectal Cancer Get access Cynthia Gail Leichman, Cynthia Gail Leichman University of Southern CaliforniaLos Angeles, Calif. Correspondence to : Cynthia G. Leichman, M.D., Division of Medical Oncology, Department of Medicine, University of Southern California School of Medicine, 1200 N. State St. #10-611, Los Angeles, CA 90033. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lawrence Leichman, Lawrence Leichman University of Southern CaliforniaLos Angeles, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Paul Spears, C. Paul Spears University of Southern CaliforniaLos Angeles, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter J. Rosen, Peter J. Rosen University of Southern CaliforniaLos Angeles, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Susan Jeffers, Susan Jeffers University of Southern CaliforniaLos Angeles, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Susan Groshen Susan Groshen University of Southern CaliforniaLos Angeles, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 1, 6 January 1993, Pages 41–44, https://doi.org/10.1093/jnci/85.1.41 Published: 06 January 1993 Article history Received: 29 April 1992 Revision received: 24 August 1992 Accepted: 01 October 1992 Published: 06 January 1993
PAINFUL HEEL, WITH A DEMONSTRATION OF A THEORY AS TO A MECHANICAL CAUSE.
Authors: JOHN JOSEPH NTJTT
Journal: JAMA (1907)

The name which heads this article is a rather unfortunate one, as it is not at all descriptive or distinctive. All pain referred to the plantar surface of the heel is not due to this condition. Bradford and Lovett say: "This is a condition in which there is a tender and painful area under the middle of the heel." Whitman describes it with calcaneobursitis. Under painful heel he includes all pain referred to the botom of the heel. When the pain is clearly localized he says: "The cause of the symptoms in such cases may be an inflamed bursa lying between the periosteum and the fatty tissue of the heel." Walsham and Hughes do not mention the subject in "Deformities of the Human Foot." Nor does Keetley refer to it in his "Orthopedic Surgery." The French surgeons, however, have recognized this condition, and Duplay has recommended an operation which is
Comprehensive Scanning of Somatic Mitochondrial DNA Alterations in Acute Leukemia Developing from Myelodysplastic Syndromes
Authors: Bjoern Linnartz, Roswitha Anglmayer, Stefanie Zanssen
Journal: Cancer Research (2004)

Abstract Myelodysplastic syndromes (MDS) are clonal myeloid disorders characterized by ineffective hematopoiesis resulting in refractory cytopenias. Transformation resulting in acute myeloblastic leukemia is the final stage in the multistep process of MDS evolution. Functional relevant mutations of mitochondrial DNA (mtDNA) have been related to sideroblastic anemia and MDS. To investigate the role of mtDNA in malignant transformation to acute leukemia, we used high-resolution techniques such as single-strand conformational polymorphism and fluorescence sequencing for investigation of the whole mitochondrial genome from blood cells of 10 patients with MDS. Functionally relevant point mutations in mitochondrial RNA and polypeptide-encoding genes were detected in 50% of patients with MDS. Their increasing mutation load connects MDS and the developing acute myeloid leukemias. Several point mutations of mtDNA, including secondary point mutations for Leber’s hereditary optic neuropathy, occur in one bone marrow and may synergically affect bone marrow stem cells by an apoptotic pathway.
Slaughter of the Innocents
Authors: Stanley N. Stark
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Adelson's article, "The Battering Child" (222:159, 1972) is thought provoking. One theme seems to run through all but one of his case presentations—the absence of adult supervision of the deceased infants and their siblings. <h3>Case 1.—</h3> Mother was gone "several hours." Should a 12-year-old watch over a retarded 8-year-old and two other siblings? <h3>Case 2.—</h3> The babysitter was in the bathroom for "an hour," leaving a 5-year-old in charge! <h3>Case 4.—</h3> The parents were out visiting. Two brothers, aged 5 and 2 years, entered the building. Who was supposed to be supervising? <h3>Case 5.—</h3> A 7-year-old was left in charge of a 6-year-old, a 4-year-old, and the infant who died. Is this proper, even if only for ten minutes? Can you neglect this behavior? Is this not child battering by a grownup, even though he did not physically strike the child? Were these psychologically battered children? It
Outcomes in Mild Acute Ischemic Stroke Treated With Intravenous Thrombolysis
Authors: Jose G. Romano, Eric E. Smith, Li Liang, Hannah Gardener, Sara Camp, Laura Shuey, Alison Cook, Iszet Campo-Bustillo, Pooja Khatri, Deepak L. Bhatt, Gregg C. Fonarow, Ralph L. Sacco, Lee H. Schwamm
Journal: JAMA Neurology (2015)

Mild strokes have been poorly represented in thrombolytic trials and only a few series have reported outcomes after treatment with intravenous (IV) recombinant tissue plasminogen activator (rtPA) after mild stroke.To report treatment complications and short-term outcomes in patients with mild stroke who have received treatment with IV rtPA.Retrospective analysis of patients treated in the emergency department of hospitals that use the Get With the Guidelines-Stroke registry, a prospectively collected quality improvement registry used by hospitals across the United States. Patients were those admitted between May 1, 2010, and October 1, 2012, with acute ischemic stroke within 4.5 hours from symptom onset and a baseline National Institutes of Health Stroke Scale score of 5 or less. Univariable and multivariable analyses were performed to identify factors independently associated with discharge outcomes and treatment complications.Intravenous rtPA.Treatment complications included symptomatic intracranial hemorrhage, life-threatening or serious systemic hemorrhage, other serious complications, and undetermined complications. The short-term outcomes analyzed were in-hospital mortality, discharge to home, independent ambulation at discharge, and length of stay.Among 33,995 patients who arrived within 4.5 hours of symptom onset and were treated with IV rtPA, 7621 (22.4%) had a National Institutes of Health Stroke Scale score of 5 or less and 5910 had complete data for analysis. Treatment complications were infrequent: symptomatic intracranial hemorrhage, 1.8%; life-threatening or serious systemic hemorrhage, 0.2%; other serious complications, 1.8%; and complications of undetermined cause, 2.4%. Mortality was low (1.3%), but at discharge 30.3% could not ambulate independently, 29.4% could not go directly home, and 73.0% had a length of stay of 3 days or longer. Worse short-term outcomes were seen in older patients, African American patients, diabetic patients, and those who arrived by ambulance, after hours, or with a higher National Institutes of Health Stroke Scale score.Many patients with ischemic stroke treated with IV rtPA have a mild stroke. Symptomatic intracranial hemorrhage is infrequent, but approximately 30% of these patients are unable to return directly home or ambulate independently at discharge. Additional studies are needed to identify strategies to improve the outcomes in patients with mild stroke who receive thrombolysis.
Association of Amiodarone Use With Acute Pancreatitis in Patients With Atrial Fibrillation
Authors: Alvaro Alonso, Richard F. MacLehose, Pamela L. Lutsey, Suma Konety, Lin Y. Chen
Journal: JAMA Internal Medicine (2015)

Amiodarone is an antiarrhythmic frequently used in the treatment of atrial fibrillation (AF). Isolated reports have suggested that use of amiodarone may cause acute pancreatitis.1–3 This potential adverse effect of amiodarone has not been explored in large studies. We assessed whether use of amiodarone or other antiarrhythmics indicated for AF management is associated with developing acute pancreatitis in a large US population.
Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions
Authors: Natalya Rapoport, Kweon-Ho Nam, Roohi Gupta, Zhongao Gao, Praveena Mohan, Allison Payne, Nick Todd, Xin Liu, Taeho Kim, Jill Shea, Courtney Scaife, Dennis L. Parker, Eun-Kee Jeong, Anne M. Kennedy
Journal: Journal of Controlled Release (2011)
Abstract B45: A cell-based screening to identify nucleolar disruptors in cancer cells
Authors: Lucia Morgado-Palacin, Susana Llanos, Carmen Blanco-Aparicio, Diego Megias, Joaquin Pastor, Manuel Serrano
Journal: Cancer Research (2013)

Abstract Cancer cells require highly elevated levels of ribosome biogenesis to meet the demand for increased protein synthesis. Ribosome biogenesis, one of the most energy demanding processes, takes place in nucleoli. Notably, changes in number, size and morphology of nucleoli have been long recognized as a reliable feature of cancer cells. Interestingly, the nucleolus is well known to be a hub in the stress response. Approximately 70% of the ~4500 nucleolus-associated proteins are involved in functions other than ribosome biogenesis, including cell cycle control, apoptosis or DNA repair. This places the nucleolus as an important integrator between ribosome synthesis, cell cycle progression and stress signaling. A large variety of cellular insults trigger alterations in the dynamics of nucleolar proteins and/or ribosomal RNA. Stabilization of the tumor suppressor p53 has been observed as a result of the relocalization of certain ribosomal proteins in the nucleoplasm, notably L5 and L11, where they can bind and inhibit MDM2. The aim of this work is to identify new potential anti-tumoral drugs by means of disrupting the nucleolar integrity. By using a high content cell-based screening in which nucleolar morphology is monitored by GFP-L37, we have identified several compounds that cause nucleolar disruption thereby leading cancer cells to proliferative arrest or apoptosis. Interestingly, one of our best hits is compound 2,4,7,9-tetramethylbenzo[b][1,8]naphthyridin-5-amine (TMBNA). This compound has been previously reported by other investigators to intercalate DNA and to activate p53, although the underlying molecular pathway is unknown. Our data indicates that TMBNA activates p53 through nucleolar disruption and binding of the ribosomal protein L11 to MDM2, ultimately resulting in cell cycle arrest and apoptosis. These results highlight the relevance of the nucleolus as a main target of cancer drugs. Citation Format: Lucia Morgado-Palacin, Susana Llanos, Carmen Blanco-Aparicio, Diego Megias, Joaquin Pastor, Manuel Serrano. A cell-based screening to identify nucleolar disruptors in cancer cells. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr B45.
Ankle sprain surgery a winner for athletes
Authors: Catherine Macek
Journal: JAMA (1982)

The escalating popularity of jogging and other running sports has resulted in an increased incidence of the most common athletic injury—the sprained ankle. But for those suffering from recurrent ankle sprains, surgical treatment is highly successful in returning the athlete to the gridiron or jogging trail, according to a study by orthopedic surgeons in Atlanta and Durham, NC. At the recent American Orthopaedic Foot Society meeting in New Orleans, Rick K. St Pierre, MD, an orthopedic resident at Emory University School of Medicine in Atlanta, reviewed 53 ankle ligamentous reconstructions carried out over a 21-year period by 16 surgeons. The patient population included 35 men and 15 women ranging in age from 14 to 40 years, with a mean age of 22 years. Many were college students who did not respond to conservative treatment, such as strapping or plaster casting. Three patients required bilateral surgery. The surgeons employed one of
Familial combined hyperlipoproteinemia. Evidence for a role of growth hormone deficiency in effecting its manifestation.
Authors: T J Merimee
Journal: Journal of Clinical Investigation (1980)

Hyperlipidemia associated with an isolated deficiency of growth hormone was investigated in 10 subjects with hypercholesterolemia consistently present over a 10-yr period. 8 of these 10 had serum triglyceride concentrations greater than 185 mg/dl. 13 growth hormone-deficient patients with normal serum lipids, 28 age-matched controls, and 6 families possessing both growth hormone-deficient and hormonally normal members were also studied. Hyperlipidemia occurred with growth hormone deficiency only in families in which hormonally normal subjects likewise exhibited hyperlipidemia. However the elevation of serum lipids, particularly cholesterol, was invariably greater in the growth hormone-deficient members of these families. Studies were most consistent with the classification of this trait as familial combined hyperlipoproteinemia. Basal serum concentrations of insulin, glucose, and free fatty acids were similar in all groups. After oral glucose (1.5 g/kg of body wt) both hyperlipidemic and normolipidemic dwarfs exhibited a similar degree of glucose intolerance associated with insulinopenia. Sensitivity to insulin, assessed after the intravenous injection of insulin (0.05 U/kg of body wt), increased and was virtually identical in the two dwarf groups. Administration of 5 mg of human growth hormone twice a day for 1 wk to five subjects did not alter serum lipid patterns. The data provide no conclusive evidence concerning a direct effect of growth hormone deficiency on hyperlipoproteinemia. We postulate that in some individuals growth hormone deficiency may unmask an underlying defect in lipoprotein metabolism.
Tobacco Industry Campaign Contributions Are Affecting Tobacco Control Policymaking in California
Authors: Stanton A. Glantz
Journal: JAMA (1994)

<h3>Objective.</h3> —To test the hypothesis that tobacco industry campaign contributions are influencing the behavior of members of the California legislature. <h3>Design.</h3> —Multivariate simultaneous-equations regression was used to analyze data on campaign contributions from the tobacco industry to members of the California legislature in 1991 and 1992, members' tobacco control policy positions, and members' personal characteristics. <h3>Data Sources.</h3> —The following sources were analyzed: campaign contributions from disclosure statements filed with the California Fair Political Practices Commission; constituent attitudes on tobacco control from the California Tobacco Survey; legislators' personal characteristics, from a survey of key informants conducted by the<i>California Journal</i>; and the tobacco policy score, a survey of key informants working on tobacco issues in the state legislature. Specific voting on tobacco-related bills was also analyzed. <h3>Setting.</h3> —California legislature in 1991 and 1992. <h3>Patients or Other Participants.</h3> —All members of the California legislature in 1991 and 1992. <h3>Main Outcome Measures.</h3> —Tobacco policy score, campaign contributions, and votes on individual tobacco-related bills. <h3>Results.</h3> —The tobacco industry is having a statistically detectable effect on behavior of members of the California legislature on tobacco policymaking. On a scale of 0 to 10, a legislator's tobacco policy score dropped (ie, became more protobacco industry) by -0.11 for every $1000 in tobacco campaign contributions, after accounting for the fact that a more protobacco position was associated with greater contributions ($1855 for each -1.0 reduction in score). Members who were rated as effective received larger contributions from the industry. Members rated higher in integrity and intelligence were more antitobacco (higher scores) and Republicans more protobacco (lower scores) after taking into account the effects of contributions from the industry. Constituent attitudes were not reflected in legislators' perceived behavior. <h3>Conclusion.</h3> —Tobacco industry campaign contributions influence California legislators in matters related to tobacco policymaking, independent of constituents' support for tobacco control. (<i>JAMA</i>. 1994;272:1176-1182)
REPRODUCIBILITY VARIANTS IN THALLIUM-201 MYOCARDIAL IMAGING
Authors: David Romo, Thomas D. Kay, Gwynne K. Neufeld, David L. Johnson, Mary E. Thompson, Sandy J. Riahi, George M. McGranahan
Journal: Clinical Nuclear Medicine (1982)

Riahi, Sandy J.; Kay, Thomas D.; Johnson, David L.; Romo, David; Thompson, Mary E.; Neufeld, Gwynne K.; McGranahan, George M. Jr. Author Information
Gestational and Chronic Low-Dose PFOA Exposures and Mammary Gland Growth and Differentiation in Three Generations of CD-1 Mice
Authors: Sally S. White, Jason P. Stanko, Kayoko Kato, Antonia M. Calafat, Erin P. Hines, Suzanne E. Fenton
Journal: Environmental Health Perspectives (2011)

Prenatal exposure to perfluorooctanoic acid (PFOA), a ubiquitous industrial surfactant, has been reported to delay mammary gland development in female mouse offspring (F1) and the treated lactating dam (P0) after gestational treatments at 3 and 5 mg PFOA/kg/day.We investigated the consequences of gestational and chronic PFOA exposure on F1 lactational function and subsequent development of F2 offspring.We treated P0 dams with 0, 1, or 5 mg PFOA/kg/day on gestation days 1-17. In addition, a second group of P0 dams treated with 0 or 1 mg/kg/day during gestation and their F1 and F2 offspring received continuous PFOA exposure (5 ppb) in drinking water. Resulting adult F1 females were bred to generate F2 offspring, whose development was monitored over postnatal days (PNDs) 1-63. F1 gland function was assessed on PND10 by timed-lactation experiments. Mammary tissue was isolated from P0, F1, and F2 females throughout the study and histologically assessed for age-appropriate development.PFOA-exposed F1 dams exhibited diminished lactational morphology, although F1 maternal behavior and F2 offspring body weights were not significantly affected by P0 treatment. In addition to reduced gland development in F1 females under all exposures, F2 females with chronic low-dose drinking-water exposures exhibited visibly slowed mammary gland differentiation from weaning onward. F2 females derived from 5 mg/kg PFOA-treated P0 dams displayed gland morphology similar to F2 chronic water exposure groups on PNDs 22-63.Gestational PFOA exposure induced delays in mammary gland development and/or lactational differentiation across three generations. Chronic, low-dose PFOA exposure in drinking water was also sufficient to alter mammary morphological development in mice, at concentrations approximating those found in contaminated human water supplies.
Gut in 2000
Authors: M. FARTHING
Journal: Gut (2000)

There are a limited number of ways in which the success of a biomedical journal can be assessed. The impact factor, with all its limitations, remains an internationally accepted index and can be used as a comparator between related specialist journals. Gut 's impact factor increased to 5.111 in 1999, placing us third behind Hepatology (5.621) and Gastroenterology (10.330). Gut is closing on the heels of Hepatology and we hope to move into second place in 2000.

Gut 's rising impact factor is likely to be one reason why the number of original manuscripts submitted to the journal has risen by an annual 8–10% during the past three to four years. We have been delighted to receive an increasing number of high quality manuscripts on liver research and can reaffirm the journal's intention to remain committed to our subtitle—“ An …