tbuckley/cabot-search huggingface dataset:
OBSERVATIONS ON THE FINE STRUCTURE OF MATURE HERPES SIMPLEX VIRUS AND ON THE COMPOSITION OF ITS NUCLEOID
Authors: M. A. Epstein
Journal: The Journal of Experimental Medicine (1962)

The fine structure and composition of mature herpes virus have been investigated in thin sections by electron microscopy. The virus was grown in cultured HeLa cells and was collected with them. Tests for the biological activity of the infected cultures were included in the first half of the work. Preparations were fixed with both osmium and permanganate, and were embedded either in methacrylate or in aquon, a water-miscible fraction of a commercially available epoxy resin. In further experiments material fixed with permanganate was subjected to the action of specific nucleases or control medium before embedding. All the preparations showed numerous uniform particles around and between the cells and this was paralleled by considerable biological activity where tests were made on samples of the culture fluids. Mature herpes virus has been found to be round and to measure, when dehydration shrinkage is avoided, about 165 mmicro in diameter. The particle contained an eccentric round-ended rod-shaped, electron-opaque nucleoid lying in an inner zone of low density. A dense outer zone or viroplasm surrounded this, no membrane being present between the two zones. After permanganate fixation the particle was found to have an outer limiting membrane showing a triple-layered structure morphologically indistinguishable from that of the plasma membrane of the HeLa cells. The results of the digestion experiments show that herpes virus contains nucleic acid of deoxyribose type and that this is localized in the dense nucleoid. Both the findings and the methods used are discussed.
HIV, Heterosexual Transmission, and Women
Authors: Mary E. Guinan
Journal: JAMA (1992)

THE HUMAN immunodeficiency virus (HIV) epidemic has moved into the heterosexual population in the United States. This probably started in the 1970s but was making significant inroads by 1982 as determined from a backcalculation model.<sup>1</sup>Given the methodologic difficulties in estimating HIV incidence, trend data may give the most reliable picture of the emerging epidemic. As of March 1992, a total of 12 881 patients with the acquired immunodeficiency syndrome (AIDS) had been reported who acquired their infection through heterosexual intercourse, 5100 men and 7781 women.<sup>2</sup> Women have outnumbered men in the heterosexual contact transmission category in the United States since the epidemic was recognized in 1981.<sup>3</sup>Four-year trends in reported AIDS cases show that women accounted for an increasing proportion of total cases between 1988 (10.4%) and 1991 (12.8%) and heterosexual contact accounted for a greater proportion of female cases each year from 1988 through 1991
Adenovirus–mediated in vivo gene transfer and expression in normal rat liver
Authors: H. A. Jaffe, C. Danel, G. Longenecker, M. Metzger, Y. Setoguchi, M. A. Rosenfeld, T. W. Gant, S. S. Thorgeirsson, L. D. Stratford-Perricaudet, M. Perricaudet, A. Pavirani, J.-P. Lecocq, R. G. Crystal
Journal: Nature Genetics (1992)
Scottish scientists hope to supply human stem cells at low cost in 2007
Authors: Bryan Christie
Journal: BMJ (2006)

Scientists in Scotland expect to supply international research teams with quality assured human embryonic stem cells next year for research and therapeutic purposes.

They aim to make cell lines available at low cost to help promote worldwide efforts to exploit the potential of stem cell technology to treat disease and develop drugs.

The initiative is the result of the establishment of Roslin Cells, a publicly funded and not for profit research centre. It combines the expertise of the Roslin Institute, which cloned Dolly the sheep; scientists at the University of Edinburgh; …
Detection of IgE‐binding activity in serum after intranasal treatment of normal rabbits with <i>P. judaica</i> extract
Authors: G. Mistrello, G. Raplsarda, P. Falagiani
Journal: Allergy (1991)

Local intranasal immunotherapy relieves the allergic symptoms of rhinitic patients but little is known about the absorption and distribution of inhaled allergens in the body. The aim of this study was to establish whether allergenic proteins are able to reach the bloodstream by penetrating through the nasal mucosa when aqueous P. judaica extract was administered into the nostrils of normal rabbits. Optimal conditions for a sensitive modified RAST (immunocapture RAST) were set up and the method was used to detect clinically relevant allergenic activity in the systemic circulation. The kinetic profile after intranasal treatment was compared with the profile after intravenous injection of the allergenic extract. The findings are discussed in relation to the mechanism by which local immunotherapy acts.
Why the TDH fails to contribute to a neurology of syntax
Authors: Alan Beretta
Journal: Behavioral and Brain Sciences (2000)

An important part of Grodzinsky's claim regarding the neurology of syntax depends on agrammatic data partitioned by the Trace Deletion Hypothesis (TDH), which is a combination of trace-deletion and default strategy. However, there is convincing evidence that the default strategy is consistently avoided by agrammatics. The TDH, therefore, is in no position to support claims about agrammatic data or the neurology of syntax.
California stem cell research unit is admired but needs better governance
Authors: B. Roehr
Journal: BMJ (2012)

The California Institute for Regenerative Medicine has done a good job overall but should make several changes to enhance its viability, credibility, and operations, says a new report.1

California voters approved the creation of the institute and authorized a $3bn (£1.9bn; €2.3bn) bond issue in 2004 to fund stem cell research. The purpose was to assure the state’s leadership in the emerging field by promoting research, jobs, and, ultimately, stem cell based treatments. It inspired a handful of other states to fund other research activities. 

The institute commissioned the report into its work and governance, which was conducted by the Institute of Medicine and released on 6 December. 

Harold …
Effect of Same‐dose Single or Dual Field Irradiation on Damage to Miniature Pig Parotid Glands
Authors: Xing Yan, Bo Hai, Zhao‐chen Shan, Chang‐yu Zheng, Chun‐mei Zhang, Song‐lin Wang
Journal: International Journal of Oral Science (2009)

To evaluate the effect of single or dual field irradiation (IR) with the same dose on damage to miniature pig parotid glands. Sixteen miniature pigs were divided into two IR groups (n=6) and a control group (n=4). The irradiation groups were subjected to 20 Gy X‐radiation to one parotid gland using single‐field or dual‐field modality by linear accelerator. The dose‐volume distributions between two IR groups were compared. Saliva from parotid glands and blood were collected at 0, 4, 8 and 16 weeks after irradiation. Parotid glands were removed at 16 weeks to evaluate tissue morphology. The irradiation dose volume distributions were significantly different between single and dual field irradiation groups (t=4.177, P=0.002), although dose volume histogramin (DVH) indicated the equal maximal dose in parotid glands. Saliva flow rates from IR side decreased dramatically at all time points in IR groups, especially in dual field irradiation group. The radiation caused changes of white blood cell count in blood, lactate dehydrogenase and amylase in serum, calcium, potassium and amylase in saliva. Morphologically, more severe radiation damage was found in irradiated parotid glands from dual field irradiation group than that from single field irradiation group. Data from this large animal model demonstrated that the radiation damage from the dual field irradiation was more severe than that of the single field irradiation at the same dose, suggesting that dose‐volume distribution is an important factor in evaluation of the radiobiology of parotid glands.
Peripheral Bone Involvement of Intravascular Large B-Cell Lymphoma on 99mTc-MDP Bone Scan and 18F-FDG PET/CT
Authors: Sun Young Oh, Gi Jeong Cheon, Eugene Jeong, Sinae Lee, Tae Gyu Park, Kisoo Pahk, Jae-Gol Choe
Journal: Clinical Nuclear Medicine (2012)

A 64-year-old man was admitted for evaluation of recently developed anemia and bone pain. The bone scan showed diffusely active lesions in the peripheral bones, symmetrically. Interestingly, 18F-FDG PET/CT revealed the hypermetabolic changes in the peripheral bones as well as the internal organs. Biopsy of bone marrow confirmed the diagnosis of intravascular B-cell lymphoma. After the 3 cycles of R-CHOP chemotherapy, 18F-FDG PET/CT showed improvement of the previous hypermetabolic lesions, suggesting good response. Intravascular B-cell lymphoma is a rare and aggressive variant of diffuse large cell lymphoma characterized by proliferation of malignant cells within the vascular lumina.
A Computer-Derived Protocol to Aid in the Diagnosis of Emergency Room Patients with Acute Chest Pain
Authors: Goldman L, Weinberg M, Weisberg M, Olshen R, Cook Ef, Sargent Rk, Lamas Ga, Dennis C, Wilson C, Deckelbaum L, Fineberg H, Stiratelli R
Journal: New England Journal of Medicine (1982)

Abstract To determine whether data available to physicians in the emergency room can accurately identify which patients with acute chest pain are having myocardial infarctions, we analyzed 482 patients at one hospital. Using recursive partitioning analysis, we constructed a decision protocol in the format of a simple flow chart to identify infarction on the basis of nine clinical factors. In prospective testing on 468 other patients at a second hospital, the protocol performed as well as the physicians. Moreover, an integration of the protocol with the physicians' judgments resulted in a classification system that preserved sensitivity for detecting infarctions, significantly improved the specificity (from 67 per cent to 77 per cent, P<0.01) and positive predictive value (from 34 per cent to 42 per cent, P = 0.016) of admission to an intensive-care area. The protocol identified a subgroup of 107 patients among whom only 5 per cent had infarctions and for whom admission to non-intensive-care areas might be appropriate. This decision protocol warrants further wide-scale prospective testing but is not ready for routine clinical use. (N Engl J Med. 1982; 307:588–96.)
1071-219 Remodeling of the left atrium and pulmonary veins following catheter ablation of atrial fibrillation
Authors: Darshan Dalal, Vinod Jayam, Chandrasekhar R Vasamreddy, Lars Lickfett, Dave Bradley, Zayd Eldadah, Timm Dickfeld, Henry Halperin, Ronald Berger, Hugh Calkins
Journal: Journal of the American College of Cardiology (2004)
Effect of Prolonged Thiazide Treatment on Renal Lithium Clearance
Authors: V. Petersen, S. Hvidt, K. Thomsen, M. Schou
Journal: BMJ (1974)

Renal lithium clearances were determined after the administration of a small test dose of lithium carbonate in 22 patients when they were on long-term treatment with thiazides and when they were not on such treatment. Thiazide administration led to a 24% reduction in the lithium clearance. Diuretic drugs should be used with caution in patients given lithium treatment, and lithium should be used with caution in patients receiving diuretic treatment.
Rx for Obesity: Eat Less, Exercise More, and—Maybe—Get More Sleep
Authors: Lynne Lamberg
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene Mutations Implicated in Some Neural Tube Defect Cases
Authors: Tracy Hampton
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OUTCOME OF SECOND-GENERATION EVEROLIMUS- AND ZOTAROLIMUS-ELUTING STENTS IN ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Matthijs A. Velders, Helen Boden, Bas L. van der Hoeven, Su-San Liem, Ernst E. van der Wall, Johan W. Jukema, Martin J. Schalij
Journal: Journal of the American College of Cardiology (2012)
The Artificial Defecator and Irrigator.
Authors: ROBERT N. BARGER
Journal: JAMA (1900)

We all recognize the importance of<i>rest</i>in the treatment and cure of disease, yet in hemorrhoids and rectal troubles we have never been able to apply this, for the reason that we must defecate daily and have never had a way for avoiding it, or of doing it artificially. To secure this much needed rest to the diseased parts I have had constructed an instrument which may be called an artificial defecator and irrigator. I have found that it suits the purpose, i. e., it evacuates the bowels without any expulsory effort, or contraction of the perineal or sphincter ani muscles, thus giving the needed rest. I have used this instrument for six months and find it not only indispensable to patients suffering from hemorrhoids and rectal troubles, but also useful after all serious surgical operations, fractures of the lower limbs, accouchement cases, in all low types of fever,
Conjunctive Antithrombotic and Thrombolytic Therapy for Coronary-Artery Occlusion
Authors: Herman K. Gold
Journal: New England Journal of Medicine (1990)

Angiographic and pathological studies have established the causative role of coronary-artery thrombosis in acute transmural myocardial infarction.1 , 2 The rupture of atheromatous plaque leads to occlusive thrombosis, which produces myocardial ischemia, tissue necrosis, and loss of ventricular function. Thrombolytic therapy for acute myocardial infarction is based on the premise that dissolving the fibrin component of a coronary thrombus is necessary and sufficient for recanalization and that reflow may save myocardium that is at risk. The magnitude of the effect, however, appears to depend on timing, and late reopening of the artery may contribute to clinical benefit through mechanisms other than myocardial . . .
Fluorouracil for Skin Blemishes and Lines
Authors: Irwin I. Lubowe
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The author of a book for laymen (that has had a wide sale) advocates the use of fluorouracil for the peeling of the skin for blemishes and lines. This type of treatment has appeared in many popular lay magazines and may cause some physicians to use this method. I am enclosing two after-slides of a patient who consulted me for treatment after fluorouracil had been used on her skin with very damaging results. The patient suffered severe pain, edema, and a dermatitis of the erythema livedo reticularis type. Fortunately, I was able to clear this damaging condition with topical applications of aluminum acetate (Burow's) solution, hydrocortisonetype cream applied topically, and prednisone, 5 mg twice daily for four weeks.
Revised Labeling for Cisapride
Authors: Jane E. Henney
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Involving patients can work in home blood glucose testing
Authors: D. Kerr
Journal: BMJ (2003)

EDITOR—According to the paper by Gray et al, the single biggest cost of implementing intensive control of blood glucose concentrations in type 2 diabetes relates to the use of home blood glucose monitoring.1 This is surprising.

Firstly, currently evidence and agreement are lacking on the role of home blood glucose monitoring in type 2 diabetes.

Secondly, …
HIV-1 Transmission during Early Infection in Men Who Have Sex with Men: A Phylodynamic Analysis
Authors: Erik M. Volz, Edward Ionides, Ethan O. Romero-Severson, Mary-Grace Brandt, Eve Mokotoff, James S. Koopman
Journal: PLoS Medicine (2013)

Erik Volz and colleagues use HIV genetic information from a cohort of men who have sex with men in Detroit, USA to dissect the timing of onward transmission during HIV infection. Please see later in the article for the Editors' Summary
Detection of Mycobacterium tuberculosis Genome in Vitreous Fluid of Eyes with Multifocal Serpiginoid Choroiditis
Authors: Reema Bansal, Kusum Sharma, Amod Gupta, Aman Sharma, Mini P. Singh, Vishali Gupta, Samyak Mulkutkar, Mohit Dogra, Mangat R. Dogra, Shivali Kamal, Surya Parkash Sharma, Paul D. Fiorella
Journal: Ophthalmology (2015)
Abstract 1199: Implications of protein kinase C (PKC)α and PKCΔ on murine mammary tumor growth and metastatic dissemination; effect of retinoids
Authors: Damian E. Berardi, María Inés Díaz Bessone, Paola B. Campodónico, Andrea Motter, Elisa D. Bal de Kier Joffé, Alejandro J. Urtreger, Laura B. Todaro
Journal: Cancer Research (2011)

Abstract The retinoid system exerts some of its effects on cell differentiation and malignant phenotype reversion through the interaction of its receptors (RAR) with different PKC isoforms. In this work, using a murine mammary tumor cell line (LM3), we studied the interaction between RARs and PKC in vitro as well as whether the overexpression of α and Δ PKC isoforms could influence the effect of retinoids on cell proliferation both in vivo and in vitro. Western blot assays showed that the pharmacological inhibition of PKCΔ (Rottlerin 5μM, 24h) impaired all trans retinoic acid (ATRA)-induced RARα1 translocation to the nucleus while the pharmacological inhibition of PKCα (Gö6976 5μM, 24h) did not affect this translocation. Moreover, immunoprecipitation assays showed that only PKCΔ co-immunoprecipitated with RARα1 after ATRA treatment, suggesting a physical interaction between both molecules. However, both PKC isoforms seemed to be necessary for RARs activation as determined by a gene reporter assay. Next, by a stable transfection procedure, we overexpressed PKCα and PKCΔ in LM3 cell line. In vitro assays showed that LM3-PKCα cells presented the highest proliferative rate and were highly responsive to ATRA treatment reducing their growth capability. These genetically modified lines were also inoculated orthotopically into the mammary glands of female BALB/c mice. Ten days later, when tumors were palpable, mice were implanted with ATRA pellets (10 mg/mouse). Tumors overexpressing PKCα presented a higher growth rate and were more metastatic than control vector-transfected LM3 cells, but showed a significant response to ATRA treatment, impairing primary tumor growth and reducing lung metastases number [Md (range) 55 (20-75) vs. 16 (0-27) in non-treated and ATRA-treated LM3-PKCα cells respectively (P&amp;lt;0.05 Mann-Whitney test)]. Both control and PKCΔ overexpressing tumors were unresponsive to retinoid treatment.We can conclude that, while PKCα overexpressing cells were more aggressive than control ones, they showed an important response to retinoid treatment both in vivo and in vitro, indicating that a retinoid therapy could be successful in human mammary tumors with high PKCα levels. On the other hand, while we found an in vitro clear interaction between PKCΔ and RARα1, the overexpression of PKCΔ did not to modulate their response to the retinoid therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1199. doi:10.1158/1538-7445.AM2011-1199
Children With Disabilities—My Patients
Authors: Ruth Kahan Kaminer
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal