SMS 201-995, A Somatostatin Analogue, and Diarrhea in the Acquired Immunodeficiency Syndrome (AIDS)
Authors: Edward N. Robinson
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 October 1988SMS 201-995, A Somatostatin Analogue, and Diarrhea in the Acquired Immunodeficiency Syndrome (AIDS)Edward N. Robinson Jr., MD, Ronald Fogel, MDEdward N. Robinson Jr., MDSearch for more papers by this author, Ronald Fogel, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-8-680 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: One manifestation of the acquired immunodeficiency syndrome (AIDS) is noninfectious, unremitting diarrhea and accompanying weight loss of unknown cause (1). Somatostatin inhibits pathologic secretion in the human intestine and also improves the secretory diarrhea of patients with AIDS who are colonized with Cryptosporidia species (2-5). We evaluated SMS 201-995, a long-acting somatostatin analogue (Sandoz, Inc., East Hanover, New Jersey) as a therapeutic approach for refractory AIDS-associated wasting and diarrhea without demonstrable cryptosporidial infestation.A 27-year-old homosexual man, with antibodies to HIV, was evaluated in March 1987 for weight loss, watery diarrhea, urgency, and fecal incontinence. He was...References1. GillinShikeAlcock JMN Malabsorption and mucosal abnormalities of the small intestine in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;102:619-22. LinkGoogle Scholar2. VinikTsaiMoattariCheungEckhauserCho ASAPFK. Somatostatin analogue (SMS 201-995) in the management of gastroenteropancreatic tumors and diarrhea syndrome. Am J Med. 1986;81:23-9. CrossrefMedlineGoogle Scholar3. EdwardsConnReadHoldsworth CPNC. The effect of somatostatin analogue SMS 201-995 on fluid and electrolyte transport in a patient with secretory diarrhea. Scan J Gastroenterol. 1986;(Suppl):259-61. CrossrefGoogle Scholar4. CookKeltonStaniszCollins DJAS. Somatostatin treatment for cryptosporidial diarrhea in a patient with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1988;108:708-9. LinkGoogle Scholar5. KatzErstadRose MBC. Treatment of severe cryptosporidiumrelated diarrhea with Octreotide in a patient with AIDS. Drug Intell Clin Pharm. 1988;22:134-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Louisville School of Medicine Louisville, KY 40292 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLanreotide Autogel in the Treatment of Idiopathic Refractory Diarrhea: Results of an Exploratory, Controlled, Before and After, Open-label, Multicenter, Prospective Clinical TrialSomatostatin Analogs in the Gastrointestinal TractOctreotide in the Management of Chemoradiotherapy-Induced Diarrhea Refractory to Loperamide in Patients with Rectal CarcinomaRole of the Enteric Nervous System in the Pathophysiology of Secretory DiarrheaSystematic review: the use of somatostatin or octreotide in refractory diarrhoeaDiarrhea in Palliative Care PatientsThe adverse effects of octreotide on the healing of colonic anastomoses in ratsNeuro-Immune Pathobiology of Infectious Enteric DiseaseOctreotide Acetate in Refractory Bone Marrow Transplant-Associated DiarrheaLanreotide inhibits human jejunal secretion induced by prostaglandin El in healthy volunteersOctreotide treatment of chemotherapy-induced diarrhoeaReview article: anti-diarrhoeal pharmacology and therapeuticsExpanding uses of octreotideTherapeutic Uses of Gastrointestinal PeptidesHuman Immunodeficiency Virus and Infectious ConsiderationsBowel rest, intravenous hydration, and continuous high-dose infusion of octreotide acetate for the treatment of chemotherapy-induced diarrhea in patients with colorectal carcinomaEffective treatment of diabetic diarrhoea with somatostatin analogue, octreotide.Octreotide in the Treatment of Disorders of the Gastrointestinal SystemEffect of Octreotide on Refractory AIDS-associated Diarrhea A Prospective, Multicenter Clinical TrialJohn P. Cello, MD, James H. Grendell, MD, Paul Basuk, MD, Douglas Simon, MD, Louis Weiss, MD, Murray Wittner, MD, Richard P. Rood, MD, C. Mel Wilcox, MD, Chris E. Forsmark, MD, Alexandra E. Read, MD, Julie A. Satow, RN, Cynthia S. Weikel, MD, Cheryl Beaumont, RNManagement of AIDS-Related DiarrheaSomatostatin and octreotide in gastroenterologyNutritional Support of Patients with AIDSPeptides of human immunodeficiency virus (HIV) evoke rat colonic electrolyte secretion inhibitable by the somatostatin analog octreotideDrug Information Analysis Service; Octreotide Use in AIDSTreatment of endocrine and nonendocrine secretory diarrheal states with Sandostatin®Future medical prospects for SandostatinAmyloidosis, Diarrhea, and a Somatostatin AnalogueCarolyn R. O'Connor, MD, Thomas M. O'Dorisio, MD 15 October 1988Volume 109, Issue 8Page: 680-681KeywordsAIDSAntibodiesDiarrheaHIVHomosexualsIncontinenceSomatostatinWeight loss Issue Published: 15 October 1988 PDF DownloadLoading ...