tbuckley/cabot-search huggingface dataset:
Air Pollution and Odor in Communities Near Industrial Swine Operations
Authors: Steve Wing, Rachel Avery Horton, Stephen W. Marshall, Kendall Thu, Mansoureh Tajik, Leah Schinasi, Susan S. Schiffman
Journal: Environmental Health Perspectives (2008)

Odors can affect health and quality of life. Industrialized animal agriculture creates odorant compounds that are components of a mixture of agents that could trigger symptoms reported by neighbors of livestock operations.We quantified swine odor episodes reported by neighbors and the relationships of these episodes with environmental measurements.Between September 2003 and September 2005, 101 nonsmoking volunteers living within 1.5 mi of industrial swine operations in 16 neighborhoods in eastern North Carolina completed twice-daily odor diaries for approximately 2 weeks. Meteorological conditions, hydrogen sulfide, and particulate matter <or= 10 microm in aerodynamic diameter (PM10) were monitored in each neighborhood. We used mixed models to partition odor variance within and between people and between neighborhoods, and to quantify relationships between environmental factors and odor.Participants reported 1,655 episodes of swine odor. In nine neighborhoods, odor was reported on more than half of study-days. Odor ratings were related to temperature, PM10, and semivolatile PM10 in standard but not mixed models. In mixed models, odor increased 0.15 +/- 0.05 units (mean +/- SE) for a 1-ppb increase in H2S, and 0.45 +/- 0.14 units for a 10-microg/m3 increase in PM10 at wind speeds > 6.75 miles per hour. The odds of reporting a change in daily activities due to odor increased 62% for each unit increase in average odor during the prior 12 hr (t-value = 7.17).This study indicates that malodor from swine operations is commonly present in these communities and that the odors reported by neighbors are related to objective environmental measurements and interruption of activities of daily life.
Nanosize Titanium Dioxide Stimulates Reactive Oxygen Species in Brain Microglia and Damages Neurons <i>in Vitro</i>
Authors: Thomas C. Long, Julianne Tajuba, Preethi Sama, Navid Saleh, Carol Swartz, Joel Parker, Susan Hester, Gregory V. Lowry, Bellina Veronesi
Journal: Environmental Health Perspectives (2007)

Titanium dioxide is a widely used nanomaterial whose photo-reactivity suggests that it could damage biological targets (e.g., brain) through oxidative stress (OS).Brain cultures of immortalized mouse microglia (BV2), rat dopaminergic (DA) neurons (N27), and primary cultures of embryonic rat striatum, were exposed to Degussa P25, a commercially available TiO(2) nanomaterial. Physical properties of P25 were measured under conditions that paralleled biological measures.P25 rapidly aggregated in physiological buffer (800-1,900 nm; 25 degrees C) and exposure media (approximately 330 nm; 37 degrees C), and maintained a negative zeta potential in both buffer (-12.2 +/- 1.6 mV) and media (-9.1 +/- 1.2 mV). BV2 microglia exposed to P25 (2.5-120 ppm) responded with an immediate and prolonged release of reactive oxygen species (ROS). Hoechst nuclear stain was reduced after 24-hr (>or=100 ppm) and 48-hr (>or=2.5 ppm) exposure. Microarray analysis on P25-exposed BV2 microglia indicated up-regulation of inflammatory, apoptotic, and cell cycling pathways and down-regulation of energy metabolism. P25 (2.5-120 ppm) stimulated increases of intracellular ATP and caspase 3/7 activity in isolated N27 neurons (24-48 hr) but did not produce cytotoxicity after 72-hr exposure. Primary cultures of rat striatum exposed to P25 (5 ppm) showed a reduction of immunohistochemically stained neurons and microscopic evidence of neuronal apoptosis after 6-hr exposure. These findings indicate that P25 stimulates ROS in BV2 microglia and is nontoxic to isolated N27 neurons. However, P25 rapidly damages neurons at low concentrations in complex brain cultures, plausibly though microglial generated ROS.
405 TREATMENT RESPONSE IN CHRONIC HCV INFECTION DEPENDS ON IFN CONCENTRATION IN THE SERUM ONE MONTH AFTER THE INITIATION OF THE TREATMENT
Authors: C. François, V. Descamps, E. Brochot, A. Baron, I. Duchaussoy, R.E. Pecquet, E. Nguyen-Khac, D. Capron, S. Castelain, G. Duverlie
Journal: Journal of Hepatology (2011)
The Insignificant Difference: Discordant Incidence of Anorexia Nervosa in Monozygotic Twins
Authors: HILDE BRUCH
Journal: American Journal of Psychiatry (1969)

Two instances of anorexia nervosa in one of a pair of monozygotic twins offered the opportunity to evaluate the relative importance of constitutional and psychological factors and to highlight patterns of experience relevant for the psychodynamic understanding of the disorder. Significant characteristics were the patients' smaller birth size, being more difficult to raise and nondominant, and parental overstressing of twinship, uniformity, and similarities. Manifest illness occurred when the leader twin established her independence and separateness. This constellation is strikingly similar to what has been recognized as characteristic for the occurrence of primary anorexia nervosa in general.
Antiallergic activity of loratadine, a non‐sedating antihistamine
Authors: W. Kreutner, R. W. Chapman, A. Gulbenkian, M. I. Siegel
Journal: Allergy (1987)

Loratadine is a new non‐sedating antihistamine. The present studies compared loratadine and terfenadine, another non‐sedating antihistamine, for their ability to inhibit the bronchial response to histamine and other autacoids which have been implicated as contributing to the symptoms of an allergic reaction. In addition, the two antihistamines were evaluated in models of immunologically mediated allergic reactions. Loratadine is a more potent inhibitor of histamine‐induced bronchospasm in guinea pigs than is terfenadine. Both antihistamines exhibit marked antiserotonin activity at doses 10 times their antihistamine ED 50 values. In contrast, loratadine and terfenadine produce little or no inhibition of the bronchial responses to methacholine, leukotriene C 4 or platelet‐activating factor. An allergic bronchospasm in guinea pigs is inhibited by loratadine (ED 50 = 0.40 mg/kg, p.o.) and terfenadine (ED 50 = 1.7 mg/kg, p.o.). The bronchospasm associated with allergic anaphylaxis in rats is significantly inhibited by 10 mg/kg, p.o. loratadine and 30 mg/kg, p.o. terfenadine. Loratadine exhibits antiallergy activity in vitro. At micromolar concentrations, loratadine inhibits the release of histamine from Con A and A23187‐stimulated rat peritoneal mast cells and the release of histamine and leukotrine C 4 from a Con A‐stimulated cloned murine mast cell line
Copper intrauterine devices and the small intestine.
Authors: P J Watney
Journal: BMJ (1978)

Copper 7 and Copper T IUDs have a tendency to enter the peritoneal cavity.  Three cases of embedded Copper 7s found two lodged in the small intestine and one in the posterior surface of the uterus.  All three patients made satisfactory recoveries from the removal operation.  The cases give no incidence of perforation but compared to .4/1000 perforations by the Lippes Loop the Copper T resulted in two perforations for 880 cases the Copper 7 1 perforation in 1156 insertions.  Early laparotomy in all cases of intra-abdominal copper bearing IUDs was necessary due to surrounding adhesions.
Motor Disorders of the Esophagus
Authors: Sidney Cohen
Journal: New England Journal of Medicine (1979)

ESOPHAGEAL motor disorders are clinical abnormalities in esophageal motility that are caused by a disruption in the neurohumoral or muscular control of peristalsis or lower-esophagealsphincter (LES) function. Recent progress in the classification, pathophysiology and treatment of the major esophageal motor disorders is presented in this review.Physiology of Esophageal FunctionThe functions of the esophagus depend on myogenic properties, innervation and circulating humoral substances. An orderly, progressive contraction of the esophageal body occurs in response to swallowing (primary peristalsis) or esophageal distension (secondary peristalsis). Both types of peristalsis have similar dimensions of amplitude and propagation, although they occur through different . . .
Boost and loss of immune responses against tumor-associated antigens in the course of pregnancy as a model for allogeneic immunotherapy
Authors: Mathias Lutz, Andrea Worschech, Miriam Alb, Sabine Gahn, Laura Bernhard, Michael Schwab, Stefanie Obermeier, Hermann Einsele, Ulrike Kämmerer, Peter Heuschmann, Erdwine Klinker, Christoph Otto, Stephan Mielke
Journal: Blood (2014)
Senile Deterioration of the Central Nervous System
Authors: T. H. Howell
Journal: BMJ (1949)

STAPH.PYOGENES AND DENTAL CARIES practically all be included in those designated pyogenes.Other staphylococci are less proteolytic and saccharolytic on substrates usually tested in culture, and are less haemolytic and toxigenic.They would therefore be less likely than Staph.pyogenes to be concerned in the aetiology of caries.Conclusion A combined clinical and bacteriologicalinvestigation using a highly sensitive and selective medium for the isola- tion of Staph.pyogenes has failed to reveal an aetiological relationship between this organism and dental caries.We desire to express our thanks to Mr. R. Bradbury, school dental officer, Borough of Stretford, for arranging and assisting with the examination of the children.
Management of Heart Failure
Authors: Nancy K. Sweitzer
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pratique du psychodrame freudien
Authors: Anne Cain
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 Pratique du psychodrame freudien Subject Area: Psychiatry and Psychology Anne Cain Anne Cain Marseille Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 267–270. https://doi.org/10.1159/000287139 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Anne Cain; Pratique du psychodrame freudien. Psychother Psychosom 31 December 1978; 29 (1-4): 267–270. https://doi.org/10.1159/000287139 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Pigmented villonodular synovitis
Authors: W. P DOCKEN, M. ZUBER
Journal: Annals of the Rheumatic Diseases (1997)

Pigmented villonodular synovitisI write with regard to the paper by Zuber and colleagues that purports to demonstrate a case of pigmented villonodular synovitis (PVNS). 1 The pathology material presented by the authors, however, is not diagnostic of PVNS, in that the cellular infiltrate did not demonstrate the large polyhedral cellsusually dubbed histiocytes-that are requisite for the diagnosis of PVNS.Villi, nodules, giant cells, and haemosiderin are not specific, and may be seen in a variety of conditions other than PVNS.It is the histiocyte that renders the pathology of PVNS unique and diagnostic.Indeed, Lichtenstein has described PVNS as a 'histiocytosis' of the synovial membrane. 2n addition, the authors suggest that in their patient PVNS was found to aVect the second to fifth MCP joints.However, the diffuse form of PVNS is nearly always monarticular; documented cases of polyarticular (usually biarticular) involvement by PVNS are exceptionally rare, and probably number less than half a dozen in the medical literature.The patient under discussion-who presented with progressive, bilateral ulnar deviation at the MCPs-most probably had rheumatoid disease, not PVNS.If there is a 'lesson' to this case, it is that the correct diagnosis of an unusual condition such as PVNS requires awareness of the characteristic clinical presentation of the disease and attentiveness to its diagnostic histopathology.
Choice of Platelet Anticoagulants
Authors: VIJAY S. KUDESIA
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 April 1984Choice of Platelet AnticoagulantsVIJAY S. KUDESIA, M.D.VIJAY S. KUDESIA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-613_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read the article by Dr. Kelton (1) with interest and found one statement questionable. Kelton wrote that "Only edetic-acid-anticoagulated capillary tubes should be used (not capillary tubes anticoagulated with heparin, because heparin causes platelet clumping and can result in a spuriously low platelet count)." In-vitro clumping of platelets resulting in a spuriously low count is one of the mechanisms of pseudothrombocytopenia; however, review of literature seems to implicate the presence of edetic acid in such a phenomenon (2). In this study platelet agglutination was seen in presence of edetic acid as well as penta-acetic acid and...References1. KELTON J. Management of pregnant patient with idiopathic thrombocytopenic purpura. Ann Inter Med. 1983;99:796-800. LinkGoogle Scholar2. SHREINERBELL DW. Pseudothrombocytopenia: manifestation of a new type of platelet agglutinin. Blood. 1973;42:541-9. CrossrefMedlineGoogle Scholar3. KJELDSBERGHERSHGOLD CE. Spurious thrombocytopenia. JAMA. 1974;227:628-30. CrossrefMedlineGoogle Scholar4. ZIEGLER Z. In vitro granulocyte-platelet rosette formation mediated by an IgG immunoglobulin. Haemostasis. 1974;3:282. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cook County Hospital 1835 W. Harrison St.; Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1984Volume 100, Issue 4Page: 613-613KeywordsAnticoagulantsCapillariesEthylenediaminetetraacetic acidHeparinPlatelets Issue Published: 1 April 1984 PDF DownloadLoading ...
Role of living liver donation: Surgery violates principles of beneficence and autonomy
Authors: M. Potts
Journal: BMJ (2003)

Editor—Neuberger and Price admit that there is a significant morbidity and an up to 1% mortality among living liver donors.1 They argue that a combination of the potential benefits to the recipient, the right of donors to make an altruistic decision to help someone else, an acceptable “societal ceiling” concerning mortality and morbidity, and an acceptable risk-benefit ratio, are sufficient for living liver donation to be morally acceptable.

However, the fundamental goals of medicine, without which medicine could not exist as a practice, are more important than either the notion of patient autonomy or a utilitarian cost-benefit analysis. The fundamental end of medicine is to help an individual sick or injured patient; from this prime goal stem the principles of non-maleficence, “Do no harm,” and beneficence, “Benefit the patient.”

The surgery to remove a portion of a healthy person's liver may benefit the recipient, but at considerable risk to the donor's health, with some risk to the donor's life. The surgery is not for the benefit of the donor's health; the surgery can only cause bodily harm to an individual who would have remained healthy otherwise. This violates both the ends of helping this individual patient and not harming this individual patient.

Utilitarian considerations, such as the benefit to the recipient or even the potential satisfaction of the donor should the transplant be successful with minimal complications to both parties, do not change this fact. Neither does the principle of patient autonomy, which is not an absolute right (as Neuberger and Price themselves recognise), but is valid in so far as it fits into the fundamental goal of medicine to help an individual patient in need.

Since surgery on the donor does not benefit the health of that individual patient and is potentially harmful, it violates both the principles of beneficence and autonomy, and should not be considered a morally acceptable part of the practice of medicine.
Metabolic Screening After the American Diabetes Association's Consensus Statement on Antipsychotic Drugs and Diabetes
Authors: Elaine H. Morrato, John W. Newcomer, Siddhesh Kamat, Onur Baser, James Harnett, Brian Cuffel
Journal: Diabetes Care (2009)

OBJECTIVE Several second-generation antipsychotic (SGA) drugs have been associated with weight gain, hyperglycemia, and dyslipidemia. We evaluated whether glucose and lipid testing increased after the American Diabetes Association (ADA) consensus statement recommending metabolic monitoring for SGA-treated patients. RESEARCH DESIGN AND METHODS Laboratory claims for serum glucose and lipid testing were identified for an incident cohort of 18,876 adults initiating SGA drugs in a U.S. commercial health plan (2001–2006) and a control group of 56,522 adults with diabetes not receiving antipsychotics. Interrupted time-series models were used to estimate the effect of ADA recommendations on baseline and annual testing trends after adjusting for differences in age, sex, mental health diagnoses, and cardiovascular risk using propensity score matching. RESULTS Mean baseline testing rates for SGA-treated patients during the study period were 23% (glucose) and 8% (lipids). Among persistent users of SGA medication, annual testing rates were 38% (glucose) and 23% (lipid). Before the ADA statement, screening rates for SGA-treated patients were increasing (glucose: baseline 3.6% per year, annual 7.2% per year; lipid: baseline 1.2% per year, annual 4.8% per year; P &amp;lt; 0.001 for each trend). Increases were similar to background testing trends in control subjects. The ADA statement was not associated with an increase in screening rates. CONCLUSIONS In a commercially insured population, glucose and lipid testing for SGA-treated adults was infrequent. A gradual increase in screening rates occurred over the 6-year period, but the changes were not temporally associated with the ADA statement. More effort is needed to improve diabetes and dyslipidemia screening in these at-risk patients.
THE VALUE OF A 24-HOUR IMAGE (FOUR-PHASE BONE SCAN) IN ASSESSING OSTEOMYELITIS
Authors: Naomi Alazraki, Fred Datz, David Dries, Peter F. Lawrence, Harry E. Greenberg, Andrew Taylor
Journal: Clinical Nuclear Medicine (1984)

To assess the value of 24-hour static images for Tc-99m-labeled phosphate bone scans in patients with suspected osteomyelitis, twenty-one scans on seventeen patients referred for evaluation of osteomyelitis were reviewed and correlated with surgical pathology and/or clinical course. Scan criteria for osteomyelitis were increasing lesion to background activity from 2 to 24 hours for four-phase study and from 2 to 6–8 hours for three-phase study. If lesion to background activity remained abnormal and unchanged, it was read as indeterminate; if lesion to background activity decreased, it was read as no osteomyelitis. Images were recorded on computer for normalization of count rates and intensities. Results showed that in 13 scans, there was agreement of no osteomyelitis with pathology and/or clinical course for both three and four-phase studies. In two cases of no osteomyelitis, three-phase studies were indeterminate or false/positive, while 24-hour image showed no osteomyelitis. In five proven osteomyelitis patients, four scans were positive (three and four-phase) and one was false/negative for four-phase, but positive for three-phase. Thus, in four of twenty-one scans, the 24-hour image favorably influenced the interpretation of the study; in one scan the 24-hour image was unfavorable. There was agreement between three and four-phase bone scans on sixteen of twenty-one scans. Accuracy for fourphase was 86%; three-phase was 76%.
Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate‐lowering properties
Authors: Daniela Dobre, Jeffrey S. Borer, Kim Fox, Karl Swedberg, Kirkwood F. Adams, John G.F. Cleland, Alain Cohen‐Solal, Mihai Gheorghiade, Francois Gueyffier, Christopher M. O'Connor, Mona Fiuzat, Athul Patak, Ileana L. Piña, Giuseppe Rosano, Hani N. Sabbah, Luigi Tavazzi, Faiez Zannad
Journal: European Journal of Heart Failure (2013)