tbuckley/cabot-search huggingface dataset:
264. Cell Therapy of Ovarian Failure: Intraovarian Transplanted Granulosa Cells Successfully Engraft and Repopulate Growing Follicles
Authors: Ayman Al-Hendy, Hui Q. Wang, Salama A. Salama
Journal: Molecular Therapy (2005)

Objectives: Ovarian failure accounts for up to 40% of women with primary amenorrhea. This condition is devastating for the patients, who, besides being infertile, will usually face an accompanying wide range of physical and psychological problems. There is currently no effective treatment for this condition apart from symptomatic management with hormone replacement therapy. The etiology of this condition is largely unknown but generally accepted to be due to defective granulosa cells. The field of cell therapy has advanced during last decade and secured some success in treating several hematological and neurological diseases. The objective of this project is to test the ability of granulosa cells to reverse the infertility phenotype of an animal model of ovarian failure. Since this is a novel concept, we wanted first to assess the fate of gene-tagged granulosa cells when transplanted intraovarian in normal syngeneic mice.
Diseases of Medical Progress: A Study of Iatrogenic Disease
Authors: David M. Spain
Journal: JAMA (1969)

The first edition of<i>Diseases of Medical Progress</i>, published almost a decade ago, was a small monograph. The second edition, published five years later, was considerably enlarged, and now this new edition is a massive volume of 925 pages. If these three editions were placed side by side on every practicing physician's desk, they would be an impressive and constant reminder of the ever-increasing and permanent place that iatrogenic diseases occupy in modern medical practice. This last edition is an encyclopedic compilation of almost everything that has appeared in the literature pertaining to iatrogenic diseases. This fact alone makes the volume a most important reference source for the harried physician. As a multiauthored book, the volume is somewhat uneven in its content, and contains some unavoidable repetition. In contrast to the first edition, this present one has enhanced value because it discusses the mechanisms of action rather than simply listing
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
Authors: Jennifer S. Isaacs, Yun Jin Jung, David R. Mole, Sunmin Lee, Carlos Torres-Cabala, Yuen-Li Chung, Maria Merino, Jane Trepel, Berton Zbar, Jorge Toro, Peter J. Ratcliffe, W. Marston Linehan, Len Neckers
Journal: Cancer Cell (2005)
Nocardia asteroides pneumonia complicating low dose methotrexate treatment of refractory rheumatoid arthritis.
Authors: J J Cornelissen, L J Bakker, M J Van der Veen, M Rozenberg-Arska, J W Bijlsma
Journal: Annals of the Rheumatic Diseases (1991)

Low dose methotrexate is used increasingly often in the treatment of rheumatoid arthritis. Severe complications due to toxicity of the lung or bone marrow occur infrequently. This report describes a 71 year old woman with longstanding rheumatoid arthritis who developed pleuritis, a pulmonary infiltrate, and pancytopenia during treatment with low dose methotrexate. Fatal respiratory insufficiency followed, and cultures from the lung after death showed Nocardia asteroides.
Charity calls for NHS to commission services to improve health of homeless people
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Health services need to be better geared to meet the needs of homeless people, the charity Crisis has said after research it commissioned showed that people living on the streets die 30 years younger than the national average.

Homeless people should be able to register more easily with a GP and be kept in hospital until accommodation and support are set up for them in the community, says the charity for single homeless people in its report.1

A review of death records in England between 2001 and 2009 identified 1731 as being those …
Care in Childbirth and beyond
Authors: Raymond S. Duff
Journal: New England Journal of Medicine (1980)

Leboyer's Birth Without Violence is an appealing work of art that celebrates the joy of normal birth and protests against unnecessary violence during delivery.1 With cleverly chosen words and captivating photographs it focuses almost exclusively on the infant. Berezin reports that the Leboyer approach to childbirth in America involves the parents as central actors with the infant, and that such involvement may not only foster "bonding" of infant to parents (a subject in fashion these days), but may also enhance the parents' competence.2 The study by Nelson and her co-workers in this issue of the Journal helps to set us . . .
Prediction of paroxysmal atrial fibrillation in patients with congestive heart failure: a prospective study
Authors: Takahisa Yamada, Masatake Fukunami, Tsuyoshi Shimonagata, Kazuaki Kumagai, Hisakazu Ogita, Yoshihiro Asano, Akio Hirata, Masatsugu Hori, Noritake Hoki
Journal: Journal of the American College of Cardiology (2000)
Endoscopic Ultrasound-Guided Bilioduodenal Anastomosis: A New Technique for Biliary Drainage
Authors: M. Giovannini, V. Moutardier, C. Pesenti, E. Bories, B. Lelong, J. Delpero
Journal: Endoscopy (2001)

Endoscopic biliary stenting is the most common method of treating obstructive jaundice. We present a new technique of biliary drainage using endoscopic ultrasound (EUS) and EUS-guided puncture of the common bile duct (CBD). A 56-year-old man with obstructive jaundice was referred for EUS and endoscopic retrograde cholangiopancreatography (ERCP) because a computed tomography (CT) scan had shown a pancreatic mass in the head of the pancreas and a dilated CBD. The patient was enrolled in a preoperative chemoradiotherapy protocol and biliary stenting was required. Deep cannulation was not obtained even after a precut and the procedure was stopped. Using a therapeutic EUS scope (FG 38X Pentax), the CBD was punctured with a 5-F needle-knife under EUS guidance and a cholangiogram was obtained. A 0.35-inch guide wire was introduced into the CBD. The EUS scope was removed and a duodenoscope was introduced, allowing the placement through the duodenum of a 10-F plastic stent. The CBD was drained properly. No complication occurred.
Student Loan Deferment
Authors: Stephen T. Amann
Journal: JAMA (1993)

To the Editor.  —I wish to express my concerns over a recent article 1 in JAMA , regarding the new changes with the reauthorization of the Higher Education Act (HEA). The article praised the grass roots campaign instituted by the American Medical Association (AMA) Resident Physicians Section. Also, the article noted that in the final bill, 2-year deferment of student loans will continue to be offered to medical students who received a federal student loan prior to July 1, 1993. A 3-year deferment will be offered to any medical resident experiencing economic hardship. Those who have never taken out a government loan prior to July 1,1993, will not have the 2-year deferment option.  For new borrowers taking out loans after June 30, 1993, there will be no 2-year deferment. The current act essentially pacifies the current pool of residents and medical students. The people who are not in medical school yet,
Management of Neonatal Asphyxia-Reply
Authors: Albert D. Warshauer
Journal: JAMA (1980)

<h3>In Reply.—</h3> I appreciate the thoughtful comments by Dr Hein and the further opportunity to discuss neonatal asphyxia. Dr Hein is skeptical of mouth-to-mouth ventilation. Is it safe regarding meconium aspiration and infection? Is it effective in correcting hypoxemia? My personal experience of approximately 20 years as an anesthesiologist indicates the answers generally are "Yes." To place mouth-to-mouth ventilation in perspective, I shall compare it to bag-and-mask and intubation. The last two methods, as Dr Hein correctly infers, provide a much higher oxygen concentration. In addition, intubation enables suctioning of the trachea by using the tube as a straw.<sup>1</sup>But other facets also are present. Mouth-to-mouth has minimal setup time. Suctioning seldom needs to be done. No airway or endotracheal tube need be inserted. Mouth-to-mouth minimizes resistance to the flow of gas. The mouth and throat are opened widely, and no tube restricts the tracheal lumen. The rule "establish
Adjuvant activity of pollen grains
Authors: Z. Allakhverdi, S. Bouguermouh, M. Rubio, G. Delespesse
Journal: Allergy (2005)

The induction of an immune response to a biologically inert soluble protein requires an adjuvant. Here we have examined whether intact grains of pollen display such adjuvant effect, accounting for the immunogenic activity of pollen protein allergens that are devoid of intrinsic pro-inflammatory/adjuvant property.Human monocyte-derived dendritic cells (DCs) were cultured with intact grains of grass or ragweed pollen for 48 h. The state of DCs maturation was analyzed by FACS and their cytokine production by ELISA. T cell priming activity of DCs was examined in co-cultures with naïve cord blood-derived CD4(+) T cells.Contact with grains of pollen induced a distinct maturation program in immature DCs. Pollen up-regulated the expression of CD54, CD80, CD83, CD86, HLA-DR, CCR7, and CD40 on DCs. Moreover, CCR5 expression was up-regulated by pollen but suppressed by LPS. In sharp contrast to LPS-stimulated DCs, pollen-treated DCs did not produce cytokines [interleukin (IL)-10, IL-12, tumor necrosis factor (TNF)-alpha] but retained the ability to secrete high levels of these cytokines upon simulation with soluble CD40 ligand and interferon (IFN)-gamma. Pollen-primed DCs strongly stimulated the proliferation of allogeneic naïve CD4(+) T cells and promoted their development into effector cells producing high levels of IL-5 and IL-13 together with moderate levels of IFN-gamma and IL-4.Intact grains of pollen induce activation and maturation of DCs in vitro. Similar mechanisms may be effective in vivo, suggesting that pollen grain is not only an allergen carrier but also acts as an adjuvant in the induction phase of the allergic immune response.
Study of Norethindrone in Contraception
Authors: Joseph W. Goldzieher
Journal: JAMA (1962)

The contraceptive effectiveness of 10 mg norethindrone plus .06 mg ethinyl estradiol, administered orally for 20 days of the menstrual cycle, was evaluated in 210 women over 6232 cycles at the Planned Parenthood Center of San Antonio, Texas. There were no unplanned pregnancies during the study period, and not a single patient discontinued use because of side effects. Dysmenorrhea and premenstrual tension diminshed considerably. The incidence of menstrual irregularities, was low. 99 of the women reported an increase in libido. Of 18 patients who discontinued use to become pregnant, 16 became pregnant within the first 3 cycles. The contraceptive effect of norethindrone is thought to be due to the inhibition of ovulation, reinforced by additional protective mechanisms.
Studies on the antigenic determinants in the self-association of IgG rheumatoid factor
Authors: FA Nardella, DC Teller, M Mannik
Journal: The Journal of Experimental Medicine (1981)

The number, location, and other characteristics of the antigenic determinants for self-association of IgG-rheumatoid factors (IgG-RF) were examined using the IgG-RF isolated from the plasma of one patient as a model system. Affinity chromatography was employed for isolation of the IgG-RF. Sedimentation equilibrium ultracentrifugation was used to study the various interactions. The antigenic valence of IgG-RF Fc, normal human Fc, and rabbit Fc fragments was two for the interaction with Fab fragments from IgG-RF, as might be expected from the molecular symmetry of IgG. The antigenic valence of intact normal IgG, however, was only one, indicating that when one of the available antigenic determinants interacted with the Fab fragment of IgG-RF, the other determinant becomes sterically inaccessible. Reduction and alkylation, known to increase the flexibility of the hinge region, did not alter the antigenic valence of IgG for Fab fragments of IgG-RF. The antigenic valence of IgG-RF in self-association could not be experimentally determined but must be two to permit the observed concentration-dependent further polymer formation of IgG-RF dimers. Unique antigenic determinants on the Fc fragments of IgG-RF were sought and not found, thus reaffirming the formation of two antigen-antibody bonds as the basis for dimerization of IgG-RF molecules. The pFc' and Fc' fragments, representing Cγ3 domains of IgG, failed to show significant interaction with Fab fragments of IgG-RF, indicating that the antigenic determinants were not expressed by the Cγ3 regions but are located either on Cγ2 region or require intact Cγ2 and Cγ3 regions for expression. These conclusions were corroborated by the antigenic valence of one for the Fc(i) fragment, a new papain-generated intermediate fragment of Fc, composed of two intact Cγ3 domains and one intact Cγ2 domain. Normal IgG, because of its valence of one for interaction with IgG-RF, would effectively terminate further polymerization of IgG-RF dimers. This may well in part explain the finding of smaller IgG-RF complexes in the serum than in synovial fluid of patients with rheumatoid arthritis.
The Impact of Retail-Sector Delivery of Artemether–Lumefantrine on Malaria Treatment of Children under Five in Kenya: A Cluster Randomized Controlled Trial
Authors: Beth P. Kangwana, Sarah V. Kedenge, Abdisalan M. Noor, Victor A. Alegana, Andrew J. Nyandigisi, Jayesh Pandit, Greg W. Fegan, James E. Todd, Simon Brooker, Robert W. Snow, Catherine A. Goodman
Journal: PLoS Medicine (2011)

It has been proposed that artemisinin-based combination therapy (ACT) be subsidised in the private sector in order to improve affordability and access. This study in western Kenya aimed to evaluate the impact of providing subsidized artemether-lumefantrine (AL) through retail providers on the coverage of prompt, effective antimalarial treatment for febrile children aged 3-59 months.We used a cluster-randomized, controlled design with nine control and nine intervention sublocations, equally distributed across three districts in western Kenya. Cross-sectional household surveys were conducted before and after the delivery of the intervention. The intervention comprised provision of subsidized packs of paediatric ACT to retail outlets, training of retail outlet staff, and community awareness activities. The primary outcome was defined as the proportion of children aged 3-59 months reporting fever in the past 2 weeks who started treatment with AL on the same day or following day of fever onset. Data were collected using structured questionnaires and analyzed based on cluster-level summaries, comparing control to intervention arms, while adjusting for other covariates. Data were collected on 2,749 children in the target age group at baseline and 2,662 at follow-up. 29% of children experienced fever within 2 weeks before the interview. At follow-up, the percentage of children receiving AL on the day of fever or the following day had risen by 14.6% points in the control arm (from 5.3% [standard deviation (SD): 3.2%] to 19.9% [SD: 10.0%]) and 40.2% points in the intervention arm (from 4.7% [SD: 3.4%] to 44.9% [SD: 11.7%]). The percentage of children receiving AL was significantly greater in the intervention arm at follow-up, with a difference between the arms of 25.0% points (95% confidence interval [CI]: 14.1%, 35.9%; unadjusted p = 0.0002, adjusted p = 0.0001). No significant differences were observed between arms in the proportion of caregivers who sought treatment for their child's fever by source, or in the child's adherence to AL.Subsidizing ACT in the retail sector can significantly increase ACT coverage for reported fevers in rural areas. Further research is needed on the impact and cost-effectiveness of such subsidy programmes at a national scale.Current Controlled Trials ISRCTN59275137 and Kenya Pharmacy and Poisons Board Ethical Committee for Clinical Trials PPB/ECCT/08/07.
Oral Glucose Tolerance Test Evaluation With Forearm and Fingertip Glucose Measurements in Pregnant Women
Authors: Charalampos Stavrianos, Eleni Anastasiou
Journal: Diabetes Care (2004)

It is known that glucose levels in capillary blood in the fingertip after a liquid glucose load are constantly higher when compared with venous blood measurements (1). Recently alternative sites for capillary blood drawing (e.g., forearm) have been proposed (2) that are less painful compared with fingertip. Data have shown that there was no significant difference between the capillary blood drawn from forearm and fingertip in diabetic patients with glucose values in a wide range (3). Nevertheless, some data have shown that glucose results from alternative sites and fingertip were not identical. This difference was more pronounced when there was a rapid increase or decrease of blood glucose …
Intracardiac Phonocardiography: Evolution from an Investigative to a Diagnostic Technique.
Authors: Charles F. Wooley
Journal: Annals of Internal Medicine (1964)

s1 April 1964Intracardiac Phonocardiography: Evolution from an Investigative to a Diagnostic Technique.Charles F. Wooley, M.D., Richard F. Leighton, M.D., Richard S. Goodwin, M.S., Joseph M. Ryan, M.D., F.A.C.P., Hugh S. Levin, M.D.Charles F. Wooley, M.D.Search for more papers by this author, Richard F. Leighton, M.D.Search for more papers by this author, Richard S. Goodwin, M.S.Search for more papers by this author, Joseph M. Ryan, M.D., F.A.C.P.Search for more papers by this author, Hugh S. Levin, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-711_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntracardiac phonocardiography, an interesting investigative technique, adds another dimension to cardiac diagnosis when combined with conventional techniques.Use of an intracardiac micromanometer (capable of recording simultaneous sound and pressure), with an image amplifier, an external speaker system and external phonocardiograms, allows certainty both as to location of the sound-sensing device and discrimination of artifact.Sixty-eight individuals (adolescents and adults) were studied with right heart catheterization. Nineteen with innocent systolic murmurs had no heart disease; 49 had organic heart disease with characteristic intracardiac murmurs. Correlation was with catheterization, angiographic or surgical findings.Typical findings included tricuspid insufficiency (six), a regurgitant systolic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 711-711KeywordsAdolescentsCardiovascular therapyCatheterizationDiagnostic techniquesHeartSystolic ejection murmur Issue Published: 1 April 1964 PDF downloadLoading ...
Intervention Techniques for the Chemically Dependent Adult: The Do's and Don'ts
Authors: Barry Liskow
Journal: JAMA (1988)

As with most diseases, substance abuse is best managed when diagnosed and treated early in its course. However, early detection of substance abuse frequently does not lead to early treatment because patients often deny to themselves and others that they have a problem.  Attempts to deal with this denial have led, in the past several years, to the development of a technique, labeled confrontation or intervention, that applies significant pressure to the substance user to accept treatment. Basically, the technique, which is well described and dramatized in this videotape, involves gathering significant others (spouse, boss, parent, children) in the user's environment and teaching them to confront the abuser in a supportive but factual manner regarding his or her past behavior resulting from substance abuse, indicate the consequences they will impose (job loss, separation, etc) if use continues, and urge/ demand that the user seek treatment. The manner in which an
High- and Low-Potency Neuroleptics in Elderly Psychiatric Patients
Authors: Marc H. Branchey
Journal: JAMA (1978)

The efficacy and side effects of a low-potency neuroleptic, thioridazine hydrochloride, and those of a high-potency neuroleptic, fluphenazine hydrochloride, were compared in 30 elderly chronic schizophrenic patients. Through a crossover design, each patient received both drugs with an intervening washout period. Although both drugs produced a similar degree of improvement, their side effects differed. Fluphenazine caused slightly more extrapyramidal effects than thioridazine, though few occurred with use of either drug. Thioridazine caused weight gain, blood pressure decreases, and ECG changes. High-potency neuroleptic agents appear to be the drugs of choice for elderly schizophrenic patients.
The Health Careers Institute: A Mental Health Strategy for an Urban Community
Authors: HARRIS B. PECK, TOM LEVIN, MELVIN ROMAN
Journal: American Journal of Psychiatry (1969)

The authors describe their experience operating a health careers program in a disadvantaged urban area. They feel that this type of mental health service is ideal for such a setting. The health careers strategy is designed to: 1) provide the manpower for its program; 2) develop personnel so as to establish more effective collaboration with allied health programs; 3) effect psychosocial change in residents of the community exposed to the program; and 4) make an effective contribution to aspects of the community's development that are closely related to the mental health of its citizens.
Plasma CXCL9 elevations correlate with chronic GVHD diagnosis
Authors: Carrie L. Kitko, John E. Levine, Barry E. Storer, Xiaoyu Chai, David A. Fox, Thomas M. Braun, Daniel R. Couriel, Paul J. Martin, Mary E. Flowers, John A. Hansen, Lawrence Chang, Megan Conlon, Bryan J. Fiema, Rachel Morgan, Prae Pongtornpipat, Kelly Lamiman, James L. M. Ferrara, Stephanie J. Lee, Sophie Paczesny
Journal: Blood (2013)
Pulse oximetry at the roadside: a study of pulse oximetry in immediate care.
Authors: P. Silverston
Journal: BMJ (1989)

The measurement of tissue oxygen saturation with a pulse oximeter is of proved value in the hospital setting. The development of a portable oximeter has allowed this investigation to be performed during the prehospital phase of a patient's care. Pulse oximetry was performed at the roadside in 25 patients with abnormal trauma scores and found to be of benefit in detecting and monitoring hypoxia in patients with airway obstruction, depressed respiration due to head injury, and, in particular, with closed chest injuries. There were no practical difficulties associated with the use of the instrument either at the roadside or in a moving ambulance. The portable pulse oximeter is a valuable aid in the prehospital monitoring of patients with trauma.