Serum Uric Acid and Cardiovascular Disease Risk
Authors: Michael H. Alderman
Journal: Annals of Internal Medicine (2000)

Letters4 April 2000Serum Uric Acid and Cardiovascular Disease RiskMichael H. Alderman, MDMichael H. Alderman, MDAlbert Einstein College of Medicine; Bronx, NY 10461 (Alderman)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Culleton and colleagues' carefully performed and valuable observational study from the Framingham Heart Study reports that the positive association between a single baseline uric acid level and cardiovascular events was not sustained after accounting for other variables (1).Other epidemiologic studies, arguably performed with equal care and with at least equally detailed knowledge of potential confounders, have found just the opposite (2, 3). The National Health and Nutrition Examination Survey (NHANES) I epidemiologic follow-up study reported a significant, independent association between increasing uric acid levels and cardiovascular events in women (2). More recently, among 7978 hypertensive participants ...References1. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med. 1999;131:7-13. LinkGoogle Scholar2. Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid to mortality and ischemic heart disease: the NHANES I epidemiologic follow-up study. Am J Epidemiol. 1995;141:637-44. CrossrefMedlineGoogle Scholar3. Alderman MH, Cohen H, Madhavan S, Kivlighn S. Serum uric acid and cardiovascular events in successfully treated hypertensive patients. Hypertension. 1999;34:144-50. CrossrefMedlineGoogle Scholar4. Franse LV, Pahor M, Di Bari M, Shorr RI, Wan JY, Somes GW, et al. Serum uric acid, its change with diuretic use and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP) [Abstract]. Am J Hypertension. 1999; 12(4 Part 2):13A. Google Scholar5. Levine W, Dyer AR, Shekelle RB, Schoenberger JA, Stamler J. Serum uric acid and 11.5-year mortality of middle-aged women: findings of the Chicago Heart Association Detection Project in Industry. J Clin Epidemiol. 1989;42:257-67. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Albert Einstein College of Medicine; Bronx, NY 10461 (Alderman) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSerum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study Bruce F. Culleton , Martin G. Larson , William B. Kannel , and Daniel Levy Serum Uric Acid and Cardiovascular Disease Risk Michael Poullis Metrics Cited byGraphene–carbon nanotube composite aerogel for selective detection of uric acidAII antagonists in hypertension, heart failure, and diabetic nephropathy: focus on losartanRenal regulation of plasma total antioxidant capacity 4 April 2000Volume 132, Issue 7Page: 591KeywordsCardiovascular disease riskEpidemiologyHealth surveysLongitudinal studiesNutritionObservational studiesRisk managementStandard deviationSystolic pressureUric acid ePublished: 15 August 2000 Issue Published: 4 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...