tbuckley/cabot-search huggingface dataset:
Increased endogenous catalase activity caused by heat stress does not protect the isolated rat heart against exogenous hydrogen peroxide
Authors: S E Steare, D M Yellon
Journal: Cardiovascular Research (1994)

Objective: The aim was to investigate the potential for the enhancement of endogenous catalase activity after heat stress to protect the isolated rat myocardium from the injurious effects of exogenous hydrogen peroxide. Methods: Male Sprague-Dawley rats were randomised to either heat stress or sham treatment. At 24 and 48 h after treatment hearts were retrogradely perfused at a constant flow rate of 10 ml·min−1. After a 15 min stabilisation period hearts were perfused with 75 μM hydrogen peroxide for 85 min. Mechanical function was measured by an intraventricular isovolumic latex balloon while coronary perfusate was collected for measurement of lactate dehydrogenase activity. At the end of the perfusion period the glutathione status of the hearts was determined. In separate experiments baseline cardiac catalase activity and glutathione state were measured 24 and 48 h after heat stress or sham treatment. Results: Cardiac catalase activity was increased by 49% at both 24 and 48 h after heat stress in comparison with sham controls. Glutathione concentrations were reduced by 12% 24 h after heat stress but had recovered by 48 h. Perfusion of sham hearts with 75 μM hydrogen peroxide resulted in a progressive decline in mechanical function as evident by a fall in developed pressure and rise in diastolic pressure. Coronary resistance also rose during the perfusion period as shown by a progressive increase of coronary perfusion pressure. Coronary effluent lactate dehydrogenase release was only increased above basal concentrations at the end of the perfusion period, whereas cardiac glutathione concentrations were severely depleted. Hearts taken 24 h after heat stress showed a reduced resistance to the effect of 75 μM hydrogen peroxide on mechanical activity, although there was no difference in the pattern of lactate dehydrogenase release or depletion of glutathione. Perfusion of hearts taken 48 h after heat stress with 75 μM hydrogen peroxide resulted in the same effect on mechanical dysfunction, coronary resistance, lactate dehydrogenase release, and cardiac glutathione depletion as sham controls. Conclusion: The increase in endogenous cardiac catalase activity caused by prior heat stress is insufficient to protect the isolated rat heart from injury induced by exogenous hydrogen peroxide.
Sacrament of the Sick
Authors: Jack Coulehan
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical Tests for Shoulder Disorders
Authors: Alexis Descatha, Diane Godeau, Zakia Mediouni
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A study of the human heart as a multiple dipole source. IV. Left ventricular hypertrophy in the presence of right bundle branch block.
Authors: J H Holt, A C Barnard, J O Kramer
Journal: Circulation (1977)

This report concerns the task of electrocardiographic (ECG) diagnosis and quantitation of left ventricular hypertrophy (LVH) in patients with right bundle branch block (RBBB). In 36 patients with RBBB the left ventricular mass (LVM) of each patient was independently known from quantitative biplane angiography. Two ECG techniques, standard 12-lead ECG and multiple dipole electrocardiography (MDECG), were evaluated. In diagnosing LVH, the best performance of the several standard ECG criteria was sensitivity = 29%, specificity = 100%, and that of the MDECG was sensitivity = 94%, specificity = 96%. In quantitating LVH, the standard ECG gave a correlation with LVM of r = 46% and a standard error of estimate of 98 g. The corresponding figures for the MDECG were r = 81% and the root mean square prediction error = 64 g. These results confirm other studies showing that the conventional ECG is of only marginal value in the task of diagnosing LVH in the presence of RBBB. In contrast, the MDECG performs well both in this task and that of quantitating LVH. The results provide further support of the accuracy of the model of the cardiac electrical generator and volume conductor used in the MDECG method.
Uses of Dreams
Authors: Louis A. Gottschalk
Journal: Psychotherapy and Psychosomatics (1995)

Editorials| February 18 2010 Uses of Dreams Subject Area: Psychiatry and Psychology Louis A. Gottschalk Louis A. Gottschalk Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, and Southern California Psychoanalytic Institute, Los Angeles, Calif., USA Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1995) 64 (3-4): 113–115. https://doi.org/10.1159/000289000 Article history Published Online: February 18 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Louis A. Gottschalk; Uses of Dreams. Psychother Psychosom 31 December 1995; 64 (3-4): 113–115. https://doi.org/10.1159/000289000 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1995Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
IN VIVO OPTICAL COHERENCE TOMOGRAPHY ASSESSMENT OF VERY LATE DRUG-ELUTING STENT THROMBOSIS COMPARED WITH LATE IN-STENT RESTENOSIS
Authors: Shinichiro Miyazaki, Yoshikazu Hiasa, Takefumi Takahashi, Po-min Chen, Keitaro Mahara, Riyo Ogura, Shinobu Hosokawa, Koichi Kishi, Ryuji Ohtani
Journal: Journal of the American College of Cardiology (2011)
Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
Authors: Sara Aleffi, Ilaria Petrai, Cristiana Bertolani, Maurizio Parola, Sebastiano Colombatto, Erica Novo, Francesco Vizzutti, Frank A. Anania, Stefano Milani, Krista Rombouts, Giacomo Laffi, Massimo Pinzani, Fabio Marra
Journal: Hepatology (2005)

Leptin upregulates collagen expression in hepatic stellate cells (HSCs), but the possible modulation of other actions has not been elucidated. The aim of this study was to investigate the expression and function of leptin receptors (ObR) in human HSCs and the biological actions regulated by leptin. Exposure of HSCs to leptin resulted in upregulation of monocyte chemoattractant protein 1 (MCP-1) expression. Leptin also increased gene expression of the proangiogenic cytokines vascular endothelial growth factor (VEGF) and angiopoietin-1, and VEGF was also upregulated at the protein level. Activated HSCs express ObRb and possibly other ObR isoforms. Exposure to leptin increased the tyrosine kinase activity of ObR immunoprecipitates and resulted in activation of signal transducer and activator of transcription 3. Several signaling pathways were activated by leptin in HSCs, including extracellular-signal–regulated kinase, Akt, and nuclear factor κB, the latter being relevant for chemokine expression. Leptin also increased the abundance of hypoxia-inducible factor 1α, which regulates angiogenic gene expression, in an extracellular-signal–regulated kinase– and phoshatidylinositol 3-kinase–dependent fashion. In vivo, leptin administration induced higher MCP-1 expression and more severe inflammation in mice after acute liver injury. Conversely, in leptin-deficient mice, the increase in MCP-1 messenger RNA and mononuclear infiltration was less marked than in wild-type littermates. Finally, ObR expression colocalized with VEGF and α-smooth muscle actin after induction of fibrosis in rats. In conclusion, ObR activation in HSCs leads to increased expression of proinflammatory and proangiogenic cytokines, indicating a complex role for leptin in the regulation of the liver wound-healing response.(HEPATOLOGY 2005;42:1339–1348.)
The Effects of Triparanol (MER-29) in Subjects with and without Coronary Artery Disease
Authors: William Hollander
Journal: JAMA (1960)

Triparanol, an inhibitor of cholesterol biosynthesis, significantly reduced the serum cholesterol in 71 of 89 subjects with and without hypercholesterolemia. The compound in a maximally effective dose of 250 mg. per day was well tolerated and caused no serious side effects. The decrease in serum cholesterol (Abell) averaged 45 mg. % and ranged from 20 to 110 mg. %. The ratio of serum cholesterol to serum phospholipid also was favorably influenced by therapy. Triparanol, as indicated by radioisotopic tracer studies, also appeared to reduce the total sterol and cholesterol content of the body by decreasing the formation of cholesterol the body. The compound appeared to have an anti-anginal effect in 12 of 28 subjects and to improve the electrocardiographic responses to exercise in 3 of 11 subjects with angina pectoris. These effects were associated with a fall in serum cholesterol.
Survival in patients without acute ST elevation after cardiac arrest and association with early coronary angiography: a post hoc analysis from the TTM trial
Authors: J. Dankiewicz, N. Nielsen, M. Annborn, T. Cronberg, D. Erlinge, Y. Gasche, C. Hassager, J. Kjaergaard, T. Pellis, H. Friberg
Journal: Intensive Care Medicine (2015)
Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone.
Authors: M Klin, M Smogorzewski, Z Ni, G Zhang, S G Massry
Journal: Journal of Clinical Investigation (1996)

Post-heparin hepatic lipase activity is reduced in chronic renal failure (CRF). This could be due to reduced synthesis, decreased activity, and/or impaired secretion of the enzyme. Further, the factor(s) responsible for such derangements are not elucidated. We examined hepatic lipase metabolism in normal, 6-wk-old CRF rats, CRF-PTX (parathyroidectomized) rats, and CRF and normal rats treated with verapamil (CRF-V, normal-V) using liver homogenate, hepatic cell culture for 8 h, and in vitro liver perfusion. The Vmax of hepatic lipase in liver homogenate was significantly (P < 0.01) reduced and the Km was significantly (P < 0.01) increased in CRF rats, but the values were normal in CRF-PTX, CRF-V, and normal-V rats. Culture of hepatic cells for 8 h was associated with an increase in hepatic lipase activity but the increment in CRF rats was significantly (P < 0.01) lower than that of normal, CRF-PTX, CRF-V, and normal-V rats. Both parathyroid hormone (PTH)-(1-84) and 1-34 inhibited the production of hepatic lipase in cultured cells from normal, CRF-PTX, CRF-V, and normal-V rats. The expression of the mRNA of the hepatic lipase was significantly reduced in CRF animals with the ratio between it and that of house keeping gene G3DPH being 15 +/-3% compared to 40 +/- 1.3% in normal, 44+/-2.9% CRF-PTX, 44 +/- 5.4% in CRF-V, and 39 +/- 3.9% in normal-V rats. Infusion of heparin to the in vitro hepatic perfusion system increased the activity of hepatic lipase in the effluent in all groups of rat except in CRF animals. Infusion of PTH-(1-34) in dose of 10(-6) M into the liver perfusion system inhibited the increase in post-heparin hepatic lipase activity. The data show that in CRF (a) the mRNA of hepatic lipase is downregulated, and hepatic lipase production, activity and release are impaired, (b) that this is due to the state of secondary hyperparathyroidism of CRF since both acute and chronic excess of PTH were associated with these abnormalities, (c) and that prevention of excess PTH by PTX of CRF rats or blocking the effect of PTH by treatment with verapamil corrected the derangement in hepatic lipase metabolism.
Pathology departments are still holding human tissue, report says
Authors: M. Day
Journal: BMJ (2008)

Seven years on from the public inquiry into the retention of organs at Alder Hey, pathology departments are still routinely holding on to human tissue because they are unsure of what to do with it, a report by the Human Tissue Authority said this week.

In the first comprehensive review of the 2004 Human Tissue Act—introduced in response to concerns about inappropriate retention of organs after postmortem examinations—the authority’s report said that disposal of human tissue remains a major problem. 

The review was based on site visits to 49 mortuaries in NHS hospitals and local authorities—targeted because initial administrative checks indicated that they might be high risk …
Insulinlike growth factor—ii/mannose 6-phosphate receptor is expressed on ccl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells
Authors: Pieter J. De Bleserc, Peggy Jannes, Sylvia C. Van Buul-Offers, Cok M. Hoogerbrugge, Christiaan F. H. Van Schravendijk, Toshiro Niki, Vera Rogiers, Jan L. Van Den Brande, Eddie Wisse, Albert Geerts
Journal: Hepatology (1995)

Transforming growth factor β (TGF-β), a potent fibrogenic cytokine, is secreted in latent form. We examined which cell type in both normal and carbon tetrachloride (CCl4)-induced fibrotic rat liver bears surface type II IGF/mannose 6-phosphate (IGF-II/M6P) receptor, known to facilitate activation of TGF-β. In addition, the role of the IGF-II/M6P receptor in activation of latent TGF-β was investigated in a coculture system with sinusoidal endothelial cells. Northern hybridization analysis for IGF-II/M6P receptor messenger RNA (mRNA) was performed on total RNA of different isolated and purified liver cell types. In normal liver, cells expressed little IGF-II/M6P receptor mRNA. In fibrotic liver, we found significant expression only in fat-storing cells. The presence of IGF-II/M6P receptors was established by [125I]IGF-II binding assays on freshly isolated fat-storing cells from normal and CCl4-exposed rat livers. We found specific binding of [125I]IGF-II only on CCl4 exposed fat-storing cells. As determined by polyacrylamide gel electrophoresis after affinity labeling, the specific binding involved 220 kD type II IGF receptors. Scatchard analysis revealed the presence of 3,043 ± 1,378 IGF-II/M6P high-affinity receptors/fat-storing cell, with a Kd of 387 ± 165 pmol/L. With a mink lung epithelial cell (Mv1Lu) proliferation inhibition assay, inhibition of proliferation (a measure of active TGF-β function) was determined using conditioned media of activated fat-storing cells, cocultures of fat-storing cells, and endothelial cells and pure endothelial cell cultures. We found that conditioned media of cocultures of fat-storing cells and endothelial cells inhibits the growth of Mv1Lu cells more strongly than conditioned media of homotypic cultures. Addition of neutralizing anti-TGF-β antibodies neutralizes this effect. The contribution of IGF-II/M6P receptors on the cell membrane of activated fat-storing cells to the activation of latent TGF-β was demonstrated by incubating the cells with M6P, or antibodies directed to the IGF-II/M6P receptor, both of which diminishes activation of TGF-β. We conclude that IGF-II/M6P receptors are present on activated fat-storing cells and that the presence of this receptor at the cell surface is necessary, but not sufficient, for activation of latent TGF-β. Other factors, derived from endothelial cells, are involved.
Continuous intrauterine copper contraception for 3 years: comparison of replacement at 2 years with continuation of use.
Authors: J Newton, R Illingworth, J Elias, J McEwan
Journal: BMJ (1977)

A total of 1245 women had a copper 7 intrauterine contraceptive device (IUD) inserted in 1971-3 were followed up for three years (22 761-5 women months of use). After 24 months 483 women elected to continue with the same copper 7 (continuation group), and 183 had their copper 7 replaced with a new one (replacement group). The subsequent pregnancy and expulsion rates were both significantly lower in the replacement group. The higher pregnancy rate among the women who continued to use their copper 7 device for a third year suggests that although the copper is still there, it is not available for contraceptive action. Replacing the device at 24 months did not seem to cause again the problems that usually occur in the first six months of IUD use.
A Lecture ON VARICOCELE IN THE FEMALE: Given to Graduates at St. Mary's Hospital, Manchester, November, 1921
Authors: W. E. Fothergill
Journal: BMJ (1921)

A RECEN-T writer remarks that perlhaps no subject in the field of gynaecology lhas been so thoroughly neglected as varicose veins in the femiale pelvis.He rightly says that tllere are but a few important clinical reports oil the topic in the literature, and lie mentions tllose by Winkel in 1886, by Dudley in 1889, by Miller and Kanavel in 1905, also Skenc's textbook written in 1895.As these communicationis are not easily available for referenice I nmay miention that I referred to tLe subject in my Hla7lndbook of Disea7ses of TWonen, publislhed in 1910, and gave a cliniical
Reversible Causes of Mental Impairment
Authors: Velandy Manohar
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The article entitled "Senility Reconsidered: Treatment Possibilities for Mental Impairment in the Elderly" by the Task Force sponsored by the National Institute on Aging (1980;244:259) is informative and helpful. There are, however, inaccuracies that have crept into it, especially in the table entitled "Reversible Causes of Mental Impairment" on p 261. The first one is Cushing's syndrome, which is denoted as a cause of dementia. In fact, Cushing's syndrome produces acute psychosis and confusional states more frequently when drug induced. Cushing's disease, itself, produces an organic brain syndrome or depression-like syndrome with about 10% making suicidal attempts.<sup>1</sup> Second, traumatic intracerebral hemorrhage is known to cause an acute organic brain syndrome (OBS), and during the recovery phase, varying degrees of neurological and intellectual impairment.<sup>2(p1065-1078)</sup>Therefore, it should be denoted as a cause of both dementia and delirium. Epidural hematoma can cause both acute OBS and dementia.
Mrs Bottomley announces changes to London's health services GPs report deterioration in community care services NHS dental care will be targeted on neediest patients GPs' current night visit fee structure will continue
Authors: L. Beecham
Journal: BMJ (1995)

# Mrs Bottomley announces changes to London's health services {#article-title-2}

Last week the health secretary announced changes to the health services in London that resulted in her being castigated by many fellow Tories (p 962). Mrs Virginia Bottomley explained in a written parliamentary answer that the changes were the results of “four comprehensive consultation exercises carried out by the relevant district health authorities.” She had, she said, taken full account of the comments, particularly about the pace of change. For example, the accident and emergency departments at Guy's and Edgware General Hospitals would not close until alternative and related services were fully equipped. Alternative facilities for treating minor injuries would be provided at both sites.

The short stay and specialist services at the Royal Hospitals Trust will be concentrated at the Royal London Hospital, in Whitechapel, and between now and the end of the century services will transfer from St Bartholomew's and the London Chest Hospitals.

Emergency and specialist services at present split between the two sites of the Guy's and St Thomas's Trust will be concentrated at St Thomas's. Guy's Hospital will be developed as a major medical research and teaching campus.

Accident and emergency services will continue to be improved at King's College and Lewisham Hospitals, with investments of pounds sterling8m and pounds sterling5m respectively. A major new neurosciences centre will be created at King's College Hospital, and the neurosurgery provided at the Brook Hospital will transfer to King's.

A new district hospital will be established at Greenwich (currently the Queen Elizabeth Military Hospital) from August.

Barnet General Hospital will be upgraded at a cost …