"Ouch-Ouch" Disease: The Osteomalacia of Cadmium Nephropathy
Authors: B. T. EMMERSON
Journal: Annals of Internal Medicine (1970)

Editorial Notes1 November 1970"Ouch-Ouch" Disease: The Osteomalacia of Cadmium NephropathyB. T. EMMERSON, M.D., F.R.A.C.P.B. T. EMMERSON, M.D., F.R.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-5-854 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA concentration of patients with a particular syndrome in one geographical location sometimes provides the necessary pointer to a single disease entity and ultimately the clue to the appreciation of a new etiological or pathological process. Itai-Itai ByŌ, the literal translation of which is "ouch-ouch" disease, is derived from the typical cry of patients with extreme bone pain due to osteomalacia, who are commonly seen in Toyama city on Japan's Inland Sea. Such patients might not be remarkable when seen individually, but the realization that a large proportion of them came from one limited area of the Fuchu-machi plain just...References1. TSUCHIYA K: Causation of Ouch-Ouch Disease (Itai-Itai ByŌ) Part I. Nature of the disease. Part II. Epidemiology and evaluation. Keio J Med 18:181-194, 195-211, 1969 CrossrefMedlineGoogle Scholar2. CHISHOLMHARRISONEBERLEIN JHW: Aminoaciduria, hypophosphatemia, and rickets in lead poisoning. Amer J Dis Child 89:159-168, 1955 Google Scholar3. NICAUDLAFITTEGROS PAA: Les lésions osseuses de l'intoxication chronique par le cadmium. Aspects radiologigues, à type de syndrome de milkman. Efficacité du traitement calcique et vitaminique (vitamin D). Bull Soc Med Hop Paris 19:204, 1942 Google Scholar4. KAZANTZISFLYNNSPOWAGE GFJ: Renal tubular malfunction and pulmonary emphysema in cadmium pigment workers. Quart J Med 32:165-192, 1963 MedlineGoogle Scholar5. BUTLERFLYNN EF: The proteinuria of renal tubular disorders. Lancet 2:978-980, 1958 CrossrefMedlineGoogle Scholar6. KENCHSUTHERLAND JE: Tryptophan content of serum albumin of normal and of cadmium-poisoned monkeys. Brit J Industr Med 24:326-329, 1967 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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BROWDER, M.D., F.A.C.P. 1 November 1970Volume 73, Issue 5Page: 854-855KeywordsAttentionBoneCadmium Issue Published: 1 November 1970 PDF downloadLoading ...