Specificity of the Philadelphia Chromosome
Authors: KONG-OO GOH
Journal: Annals of Internal Medicine (1964)

Article1 October 1964Specificity of the Philadelphia ChromosomeCytogenic Studies in Cases of Chronic Myelocytic Leukemia and Myeloid MetaplasiaKONG-OO GOH, M.D., SCOTT N. SWISHER, M.D., F.A.C.P.KONG-OO GOH, M.D.Search for more papers by this author, SCOTT N. SWISHER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-609 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1960 Nowell And Hungerford demonstrated a "cancer cell marker" in cytogenetic studies of the leukocyte chromosome pattern in chronic myelocytic leukemia (1). This finding has been confirmed by others (2-6), and the name "Philadelphia" or "Ph1" has been applied to this abnormal chromosome (3).Our interest in cytogenetic studies was stimulated by the difficulties encountered in the clinical differential diagnosis of occasional cases of chronic myelocytic leukemia (CML) and myeloid metaplasia (MM). It has been found that mature peripheral blood neutrophils in cases of polycythemia vera and in most cases of myeloid metaplasia have high activity of alkaline phosphatase....References1. NOWELLHUNGERFORD PCDA: A minute chromosome in human chronic granulocytic leukemia (abstract). Science 132: 1497, 1960. Google Scholar2. BAIKIECOURT-BROWNBUCKTONHARNDENJACOBSTOUGH AGWMKEDGPAIM: A possible specific chromosome abnormality in human chronic myeloid leukaemia. Nature (London) 188: 1165, 1960. CrossrefMedlineGoogle Scholar3. 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Google Scholar26. GERMANDEMAYOBEARN JAA: Inheritance of an abnormal chromosome in Down's syndrome (mongolism) with leukemia. Amer. J. Hum. Genet. 14: 31, 1962. MedlineGoogle Scholar27. BUCKTONJACOBSCOURT-BROWNDOLL KEPWR: A study of the chromosome damage persisting after X-ray therapy for ankylosing spondylitis. Lancet 2: 676, 1962. CrossrefMedlineGoogle Scholar28. CHUGILESPASSANO ENK: Types and frequencies of human chromosome aberrations induced by X-ray. Proc. Nat. Acad. Sci. USA 47: 830, 1961. CrossrefMedlineGoogle Scholar29. CONENLANSKY PEGS: Chromosome damage during nitrogen mustard therapy. A case report. Brit. Med. J. 2: 1055, 1961. CrossrefMedlineGoogle Scholar30. ANSTEYKEMPSTAFFORDTANNER LNHJLRK: Leukocyte alkaline-phosphatase activity in polycythaemia rubra vera. Brit. J. Haemat. 9: 91, 1963. CrossrefMedlineGoogle Scholar31. HONDAPUNNETTCHARNEYMILLERTHIEDE FHEJH: Serial cytogenetic and hematologic studies on a trisomy-21 mongol with acute congenital leukemia. J. Pediat. (in press). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New YorkFrom the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.Supported in part by the Monroe County Cancer Association and the Blood Research Fund of the University of Rochester, Rochester, N. Y.Presented in part at the Forty-fifth Annual Session of the American College of Physicians at Atlantic City, N. J., April 6-10, 1964.Requests for reprints should be addressed to Kong-oo Goh, M.D., The University of Rochester School of Medicine and Dentistry, Strong Memorial Hospital, 260 Crittenden Blvd., Rochester, N. Y. 14620. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIsochromosome 17q in Ph-negative chronic myelocytic leukemiaDiagnosis and management of myeloproliferative disordersIn vivo leukemic transformation: Cytogenetic evidence of in vivo leukemic transformation of engrafted marrow cellsCytogenetic Studies of the Spleen in Chronic Granulocytic LeukaemiaThe Peripheral Blood in Polycythaemia Vera and MyelofibrosisChromosomal Changes in Human Tumors and LeukemiasParoxysmal Nocturnal Haemoglobinuria and Chronic Myeloid Leukaemia in the Same PatientAnomalies of the Small Acrocentric (chromosomes in Human Tumour Cells*Spontaneous Cyclic Leukocytosis and Thrombocytosis in Chronic Granulocytic LeukemiaTesting for Ph 1 Chromosome on Mailed Specimens of Peripheral BloodBIBLIOGRAPHYChronic myelocytic leukemia.Chromosome studies of a patient and his nonleukemic identical twinChromosomentranslokation bei chronisch-myeloproliferativem SyndromPhiladelphia-Chromosom und alkalische Leukocyten-Phosphatase bei chronischer MyeloseCHROMOSOMES IN EFFUSIONSATYPICAL Ph1 CHROMOSOME BY PERICENTRIC INVERSIONObservations cytogénétiques dans la maladie de VaquezHeredity and Malignancies of The Reticuloendothelial SystemZur Frage der Zuordnung von Genen zu bestimmten Autosomen des Menschen mit Hilfe von ChromosomenaberrationenAUTOLOGOUS VERSUS HOMOLOGOUS CULTURE MEDIA IN BLOOD CULTURES FROM PATIENTS WITH CHRONIC MYELOGENOUS LEUKAEMIA. COMPARISON OF THE CYTOGENETIC PICTURESObservations on the in vitro Growth of Peripheral Leucocytes from Patients with Myeloproliferative DisordersHuman Effects of Chronic, Low Dose RadiationChronic Neutrophilic LeukemiaHARRY RUBIN, M.D.CHRONIC MYELOID LEUKÆMIA ASSOCIATED WITH MULTIPLE CHROMOSOME ABNORMALITIESCase 28-1966Coexistent lymphosarcoma and chronic granulocytic leukemiaChromosome abnormalities in human cancer. Report of a patient with chronic myelocytic leukemia and his nonleukemic monozygotic twinPhiladelphia Chromosome Abnormality in Agnogenic Myeloid MetaplasiaRALPH H. FORRESTER, JOSE M. LOURODoppel-Philadelphia-Chromosom und Isochromosom 17 in der terminalen Phase der chronischen myeloischen LeukämieChromosomenuntersuchungen bei chronisch-myeloischer LeukämieHuman cytogenetics 1 October 1964Volume 61, Issue 4Page: 609-624KeywordsBloodBone marrowChromosomesChronic myelocytic leukemiaCytogeneticsHematocritPhosphatasesResearch laboratoriesSplenomegalyWhite blood cells Issue Published: 1 October 1964 PDF DownloadLoading ...