A New Role for Glucagon
Authors: Francis C. Wood, Daniel Porte
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 April 1967A New Role for GlucagonFRANCIS C. WOOD JR., M.D., DANIEL PORTE JR., M.D.FRANCIS C. WOOD JR., M.D.Search for more papers by this author, DANIEL PORTE JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-812 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent months corroborating reports have established two new facts about glucagon: [1] Glucagon is a potent stimulus to insulin release, and [2] glucagon, or a compound closely related immunochemically and physiologically, can be isolated from the gastrointestinal tract. These unanticipated discoveries are leading to a reappraisal of the concept that the major role of glucagon is the maintenance of glucose homeostasis by increasing hepatic glucose production during hypoglycemia or starvation.Early demonstrations of insulin release after glucagon administration were thought to reflect a secondary response to induced hyperglycemia. However, insulin release has been shown in vitro to occur without...References1. GRODSKYBENNETT GMLL: Time sequence in the release of insulin: the effect of glucose, glucagon and potassium. Diabetes 15: 521, 1966. Google Scholar2. DEVRIMRECANT SL: Effect of glucagon on insulin release in vitro. Lancet 2: 1227, 1966. CrossrefMedlineGoogle Scholar3. SAMOLSMARRIMARKS EGV: Interrelationship of glucagon, insulin and glucose: the insulinogenic effect of glucagon. Diabetes 15: 855, 1966. CrossrefMedlineGoogle Scholar4. CROCKFORDPORTEWOODWILLIAMS PMDFCRH: Effect of glucagon on serum insulin, plasma glucose and free fatty acids in man. Metabolism 15: 114, 1966. CrossrefMedlineGoogle Scholar5. SOKAL JE: Glucagon—an essential hormone. Amer. J. Med. 41: 331, 1966. CrossrefMedlineGoogle Scholar6. KETTERERDUPRÉEISENTRAUTUNGER HJAMRH: Insulin-releasing factors of the gastrointestinal tract. Diabetes 15: 522, 1966. Google Scholar7. MAKMANSUTHERLAND MHEW: Use of liver adenyl cyclase for assay of glucagon in human gastro-intestinal tract and pancreas. Endocrinology 75: 127, 1964. CrossrefMedlineGoogle Scholar8. SAMOLSTYLERMEGYESIMARKS EJCV: Immunochemical glucagon in human pancreas, gut, and plasma. Lancet 2: 727, 1966. CrossrefMedlineGoogle Scholar9. HANSONOHNEDAEISENTRAUTUNGER JAARH: Characterization of gut "glucagon" (abstract). Clin. Res. 15: 43, 1967. Google Scholar10. MCINTYREHOLDSWORTHTURNER NCDDS: New interpretation of oral glucose tolerance. Lancet 2: 20, 1964. CrossrefMedlineGoogle Scholar11. ELRICKSTIMMLERHLADARAI HLCJY: Plasma insulin response to oral and intravenous glucose administration. J. Clin. Endocr. 24: 1076, 1964. CrossrefGoogle Scholar12. DUPRÉROJASWHITEUNGERBECK JLJJRHJC: Effects of secretin on insulin and glucagon in portal and peripheral blood in man. Lancet 2: 26, 1966. CrossrefMedlineGoogle Scholar13. KETTEREROHNEDADUPRÉEISENTRAUTUNGER HAJARH: Effects of enteric hormones on insulin and glucagon secretion. J. Lab. Clin. Med. 68: 888, 1966. Google Scholar14. SAMOLSTYLERMARRIMARKS EJGV: Stimulation of glucagon secretion by oral glucose. Lancet 2: 1257, 1965. CrossrefMedlineGoogle Scholar15. UNGEREISENTRAUTMADISON RHAMLL: The effects of total starvation upon the levels of circulating glucagon and insulin in man. J. Clin. Invest. 42: 1031, 1963. CrossrefMedlineGoogle Scholar16. CAHILLHERRERAMORGANSOELDNERSTEINKELEVYREICHARDKIPNIS GFMGAPJSJPLGADM: Hormone-fuel interrelationships during fasting. J. Clin. Invest. 45: 1751, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRANCIS C. WOODJR., M.D.; DANIEL PORTEJR., M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGlucagonCarbohydrate Metabolism in EskimosCardiovascular effects of glucagon in man 1 April 1967Volume 66, Issue 4Page: 812-813KeywordsGastrointestinal tractGlucagonGlucoseHyperglycemiaHypoglycemiaInsulinStarvation ePublished: 1 December 2008 Issue Published: 1 April 1967 PDF downloadLoading ...