tbuckley/cabot-search huggingface dataset:
USE OF MEDICAL THERAPY IN PATIENTS 12 MONTHS POST-ACUTE MYOCARDIAL INFARCTION
Authors: Sarah B. Windle, Sonia Grandi, Avi Shimony, Andre Gervais, Lawrence Joseph, Jennifer O&apos;Loughlin, Gilles Paradis, St&eacute;phane Rinfret, Louise Pilote, Mark Eisenberg
Journal: Journal of the American College of Cardiology (2012)
Murder most ordinary
Authors: T. Dalrymple
Journal: BMJ (2008)

Perhaps it is only my nostalgia for the good old days, but I can’t help believing that coroner’s courts used to be less hostile to—or merely less searching of—doctors than they are now.

The first time I ever attended a coroner’s court is etched on my memory. For some reason, the flat and monotonous voice of a pathologist, reading out the findings from his postmortem examination of a murder victim over the public address system in the lobby of the court, was more soothing than, say, pop music.

I realised I had nothing to fear when the coroner assured the family of the deceased in the case before mine, a man who died as a result of …
Case finding for the fragile X syndrome and its consequences
Authors: G. Turner, H. Robinson, S. Wake, S. Laing, M. Partington
Journal: BMJ (1997)

The fragile X syndrome is a cause of mental disability in both males (1/4000 births) and females (1/8000 births). 1 Diagnosis is often delayed into mid-childhood or beyond, and in some families it is never made.The inheritance pattern is X linked, which means that members of the extended family are at risk of being carriers.These individuals have a right to information and counselling in making their own choices about reproduction.In New South Wales a programme of active case finding has been in place for 10 years. 2 We describe this programme and look at the outcome and possible future directions.
The Patient with Cancer, the Referring Physician and the Radiation Therapist
Authors: Victor Drucker
Journal: New England Journal of Medicine (1957)

THE radiation therapist holds a somewhat unenviable position in medicine. The surgeon and he are the only physician specialists who presently can offer the cancer patient any hope of cure or palliation: yet, he must regretfully admit that he does not share any of the high esteem and regard accorded the former by that patient. Furthermore, the patient is usually apprehensive of him and fearful of his armamentarium of roentgen rays, radium and radioactive isotopes. The radiologist himself is unhappy about the fact that such a small percentage of these patients will be completely cured. The entire picture is one . . .
HPV Prevalence and Transmission
Authors: Tyler Cymet
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract BS1-2: Reactive Stroma as Therapeutic Targets in Breast Cancer Bone Metastasis
Authors: Y Kang
Journal: Cancer Research (2012)

Abstract Metastasis represents the most devastating stage of cancer progression. Bone metastasis is a frequent occurrence in breast cancer, affecting more than 70% of late stage cancer patients. Discovering bone metastasis genes that are clinically relevant and functionally important are critical for the development of novel therapeutics for high-risk breast cancer patients. We apply a multidisciplinary approach to analyze the molecular basis of breast cancer bone metastasis, combining functional genomics tools with animal models and clinical analysis of cancer metastasis. Candidate bone metastasis genes were identified from gene expression profiling of highly bone metastatic cells derived after in vivo selection in animal models. Functional characterization of these genes revealed their novel role in mediating tumor-stromal interactions essential for the formation of osteolytic bone metastasis. We discovered a novel metalloprotease-initiated, EGFR-dependent paracrine signaling cascade among tumor cells, osteoblasts and osteoclasts that promotes the maturation of bone-degrading osteoclasts and formation of osteolytic lesions. Using in vivo imaging technology, we showed that TGFbis released from bone matrix upon bone destruction, and signals to breast cancer to further enhance their malignancy in developing bone metastasis. We furthered identified Jagged1 as a TGFb target genes in tumor cells that engaged bone stromal cells through the activation of Notch signaling to provide a positive feedback to promote tumor growth and to activate osteoclast differentiation. More recently, we identified osteoclast-derived miRNAs as biomarkers and therapeutic targets of osteolytic bone metastasis. Importantly, pharmaceutical inhibitors against EGFR, TGFb and Notch signaling pathways and miRNAs blocking osteoclast differentiation significantly reduce the development of bone metastasis, suggesting novel avenues for clinical management of skeletal complications of breast cancer. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr BS1-2.
Effect of aminonucleoside nephrosis on immune complex localization in autologous immune complex nephropathy in rats.
Authors: W G Couser, N B Jermanovich, S Belok, M M Stilmant, J R Hoyer
Journal: Journal of Clinical Investigation (1978)

The effect of increased capillary permeability on glomerular immune complex localization was studied in rats immunized with proximal tubular antigen (Fx1A) to induce autologous immune complex nephropathy (AICN). AICN rats were made proteinuric by injection or unilateral renal perfusion with aminonucleoside of puromycin (PA) before developing subepithelial complex deposits. Control AICN kidneys developed diffuse granular deposits of IgG and Fx1A on the subepithelial surface of the glomerular basement membrane (GBM) at 3 wk by immunofluorescence and electron microscopy, and deposits increased in subsequent weekly biopsies. In contrast, PA-nephrotic AICN kidneys developed few or no GBM deposits and a significant increase in mesangial localization of IgG and Fx1A during the period of PA-induced proteinuria. These alterations in complex localization were documented both in rats with PA nephrosis and in unilaterally PA-nephrotic kidneys compared with contralateral controls in the same animals, thus excluding any effect of PA on the immunopathogenetic mechanism in AICN as an explanation for these findings. The absence of GBM deposits closely correlated with reduced staining for polyanionic glomerular sialoprotein in proteinuric kidneys, since PA-perfused kidneys studied 2 wk after resolution of proteinuria demonstrated return of normal staining for sialoprotein and development of subepithelial complex deposits similar to those in contralateral control kidneys. These studies demonstrate that properties of the glomerulus itself play an important role in determining the site of complex deposition in experimental AICN and suggest that electrophysical characteristics of the glomerular capillary wall may influence complex localization on the GBM.
Sour grapes: our changing relationship with alcohol
Authors: D. Spence
Journal: BMJ (2011)

We are not French—we are party people. A pervading British logic runs: “Why drink frequent, small amounts of alcohol when we can save our weekly rations for the weekend?” Sod the medical advice, because celebratory or (depending on your view) binge drinking is in our bloodstream and is a defining British social trait. City centres on weekend nights are full of young people spewed across the pavements, decerebrated through alcohol. Hair awry, crumpled clothes: these are just friendly fire casualties of our “work hard, play harder” culture. Emergency services look on, too bemused …
Association of Electrocardiographically Determined Left Ventricular Mass With Incident Diabetes, 1985–1986 to 2010–2011
Authors: Mercedes R. Carnethon, Hongyan Ning, Elsayed Z. Soliman, Cora E. Lewis, Pamela J. Schreiner, Stephen Sidney, Donald M. Lloyd-Jones
Journal: Diabetes Care (2012)

Electrocardiographic indices reflecting left ventricular hypertrophy are associated with incident diabetes in clinical populations at risk for coronary heart disease. We tested whether electrocardiographically determined left ventricular mass was positively associated with incident diabetes in a population sample.Coronary Artery Risk Development in Young Adults (CARDIA) study participants (n = 4,739) were followed from 1985-1986 to 2010-2011 for incident diabetes. Validated sex- and race-specific formulas were applied to standard electrocardiograms to determine left ventricular mass.Over 25 years, 444 participants developed diabetes (9.4%). After adjustment for demographic, behavioral, and clinical covariates, participants in the highest quartile of left ventricular mass index (LVMI) were twice as likely to develop diabetes than participants in the lower three quartiles (hazard ratio 2.61 [95% CI 2.16-3.17]). Neither Cornell voltage nor Cornell voltage product was associated with incident diabetes in fully adjusted models.Electrocardiographically determined LVMI may be a useful noninvasive marker for identifying adults at risk for diabetes.
The use of Toll-like receptor-7 agonist in the treatment of basal cell carcinoma: an overview
Authors: E. Stockfleth, U. Trefzer, C. Garcia-Bartels, T. Wegner, T. Schmook, W. Sterry
Journal: British Journal of Dermatology (2003)

Journal Article The use of Toll‐like receptor‐7 agonist in the treatment of basal cell carcinoma: an overview Get access E. Stockfleth, E. Stockfleth Department of Dermatology, University Hospital Charité, Schumannstraße 20–21, D‐10117 Berlin, Germany Prof. Dr med. E Stockfleth E‐mail: eggert.stockfleth@charite.de Search for other works by this author on: Oxford Academic Google Scholar U. Trefzer, U. Trefzer Department of Dermatology, University Hospital Charité, Schumannstraße 20–21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar C. Garcia‐Bartels, C. Garcia‐Bartels Department of Dermatology, University Hospital Charité, Schumannstraße 20–21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Wegner, T. Wegner Department of Dermatology, University Hospital Charité, Schumannstraße 20–21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Schmook, T. Schmook Department of Dermatology, University Hospital Charité, Schumannstraße 20–21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar W. Sterry W. Sterry Department of Dermatology, University Hospital Charité, Schumannstraße 20–21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue s66, 1 November 2003, Pages 53–56, https://doi.org/10.1046/j.0366-077X.2003.05626.x Published: 01 November 2003
Tomographic Study of the Inflection Points of the Pressure–Volume Curve in Acute Lung Injury
Authors: Guillermo M. Albaiceta, Francisco Taboada, Diego Parra, Luis H. Luyando, Juan Calvo, Rafael Menendez, Jesús Otero
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

The inflection points of the pressure-volume curve have been used for setting mechanical ventilation in patients with acute lung injury. However, the lung status at these points has never been specifically addressed. In 12 patients with early lung injury we traced both limbs of the pressure-volume curve by means of a stepwise change in airway pressure, and a computed tomography (CT) scan slice was obtained for every pressure level. Although aeration (increase in normally aerated lung) and recruitment (decrease in nonaerated lung) were parallel and continuous along the pressure axis during inflation, loss of aeration and derecruitment were only significant at pressures below the point of maximum curvature on the deflation limb of the pressure-volume curve. This point was related to a higher amount of normally aerated tissue and a lower amount of nonaerated tissue when compared with the lower inflection point on both limbs of the curve. Aeration at the inflection points was similar in lung injury from pulmonary or extrapulmonary origin. There were no significant changes in hyperinflated lung tissue. These results support the use of the deflation limb of the pressure-volume curve for positive end-expiratory pressure setting in patients with acute lung injury.
Real-world Experience in the Midst of an Exserohilum Meningitis Outbreak
Authors: George R. Thompson, Dimitrios P. Kontoyiannis, Thomas F. Patterson
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholestasis with altered structure and function of hepatocyte tight junction and decreased expression of canalicular multispecific organic anion transporter in a rat model of colitis
Authors: Takumi Kawaguchi, Shotaro Sakisaka, Keiichi Mitsuyama, Masaru Harada, Hironori Koga, Eitaro Taniguchi, Kurumi Sasatomi, Rina Kimura, Takato Ueno, Norimasa Sawada, Michio Mori, Michio Sata
Journal: Hepatology (2000)

Cholestasis is frequently associated with inflammatory bowel disease. Because some cholestasis is resulted from altered hepatocyte tight junctions (TJs) or the canalicular multispecific organic anion transporter, we have investigated the following topics in a rat model of inflammatory bowel disease: (1) alterations in hepatocyte TJs and in the canalicular multispecific organic anion transporter, (2) etiologic factors for cholestasis, and (3) effects of antibiotics on cholestasis. Rats with trinitrobenzene sulfonic acid-induced colitis were studied 24 hours after treatment. Hepatocyte TJs and the canalicular multispecific organic anion transporter were evaluated by immunostaining for TJ-associated proteins, 7H6 and ZO-1, and multidrug resistance protein 2 (mrp2). To investigate etiologic factors causing cholestasis, portal endotoxin and proinflammatory cytokines were examined. The effects of polymyxin B, penicillin G, or metronidazole on immunostaining for 7H6, ZO-1, mrp2, and cholestasis were investigated. (1) Immunostaining for 7H6 and ZO-1 colocalized outlining the bile canaliculi and immunostaining for mrp2 localized on the canalicular membrane in controls. Treatment with trinitrobenzene sulfonic acid induced significant cholestasis and caused translocation of immunostaining for 7H6, but not that for ZO-1, to the cytoplasm and diminished immunostaining for mrp2 on the canaliculus membrane. (2) The levels of portal endotoxin, but not proinflammatory cytokines, was increased. (3) Polymyxin B, but not the other antibiotics, prevented alterations in immunostaining for both 7H6 and mrp2, and cholestasis. We described that both hepatocyte TJs and the canalicular multispecific organic anion transporter were altered and that gut-derived endotoxin levels in the portal blood were increased in this rat colitis model.
IT-02 * INITIATION OF CLINICAL STUDIES WITH SL-701, A SYNTHETIC MULTI-PEPTIDE VACCINE WITH ENHANCED IMMUNOSTIMULATORY PROPERTIES TARGETING MULTIPLE GLIOMA-ASSOCIATED ANTIGENS, IN ADULTS WITH FIRST RECURRENCE OF GLIOBLASTOMA
Authors: J. Boockvar, I. Bodhinayake, C. Brooks, J. Chen, J. Schwartz, E. Rowinsky, D. Reardon
Journal: Neuro-Oncology (2014)

Immune targeting presents an important therapeutic approach in glioblastoma (GBM). The SL-701 vaccine, a synthetic multi-peptide designed to induce maximal activation of the immune system against key targets in gliomas involving adults and children, demonstrated tumor regression and durable complete and partial responses when administered in combination with poly:ICLC in investigator-sponsored Phase 1/2 trials in adults with GBM and children with high- grade glioma and diffuse intrinsic pontine glioma (Okada et al., JCO, 29(3):330-6 2011; Pollack et al., JCO 2014 in press). We present an optimized version of this therapy for enhanced immune stimulation with the addition of a synthetic, highly immunogenic mutant to target survivin, a member of the inhibitor of apoptosis family of proteins that is overexpressed in tumors. Other immunogenic mutant peptides in SL-701 target interleukin-13 receptor alpha-2 (IL-13Rα2), which has also been constructed with an amino acid substitution to enhance immunostimulatory activity, and ephrin A2 (EphA2). Most glioma cell lines and primary tumor tissues from patients studied to date express 2 or 3 of these targets. Additionally, target expression was seen on cancer stem cells (CSCs) of GBM. Along with SL-701's well-selected peptide constituents, the immunostimulants GM-CSF and imiquimod, which activate multiple arms of the immune system, will be co-administered to further augment the immune response. Treatment will be delivered as a subcutaneous injection every 2 weeks for 6 months and every 28 days thereafter. This optimized version of SL-701 is now entering a multicenter clinical trial for adult patients with first recurrence GBM with the primary endpoints of overall response rate and overall survival.
US Supreme Court delays enforcement of strict Texas abortion law
Authors: M. McCarthy
Journal: BMJ (2014)

The US Supreme Court has temporarily blocked enforcement of parts of a Texas abortion law that had reduced the number of operating abortion clinics to seven. Texas is larger than France and the second largest state in area and, with 26 million people, the second most populous.

The order, issued 14 October,1 bars the enforcement of a requirement that all abortion clinics, even those that handle only medical abortions, must meet the facility standards required for ambulatory surgical centers, pending the outcome of a …
A mRNA coding for an inactive gamma-glutamyl transpeptidase in human tissues
Authors: G. Guellaën, A. Pawlak, E.H. Cohen, J.N. Octave, R. Schwhickhardt, F. Bulle, N. Chikhi, J.H. Baik, G. Ginili, S. Siegrist
Journal: Journal of Hepatology (1990)
TCT-129 Percutaneous Transfemoral Management of Severe Secondary Tricuspid Regurgitation with Edwards Sapien XT Bioprosthesis in patients with severe heart failure: first in man experience
Authors: Michael Laule, Gert Baumann, Fabian Knebel, Wasiem Sanad, Verena Stangl, Karl Stangl
Journal: Journal of the American College of Cardiology (2013)
A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13
Authors: Alexandra Schiviz, Kuno Wuersch, Christina Piskernik, Barbara Dietrich, Werner Hoellriegl, Hanspeter Rottensteiner, Friedrich Scheiflinger, Hans Peter Schwarz, Eva-Maria Muchitsch
Journal: Blood (2012)
Viral Burden and Disease Progression in HIV-1–Infected Patients with Sickle Cell Anemia
Authors: Omar Bagasra, Robert M. Steiner, Samir K. Ballas, Oswaldo Castro, Geethanjali Dornadula, Stephen Embury, Donald Jungkind, Lisa Bobroski, Abdullah Kutlar, Sandra Burchott
Journal: American Journal of Hematology (1998)

The spleen and lymph nodes are major sites of human immunodeficiency virus type 1 (HIV-1) replication, mutation, and genetic variation in vivo. If a major portion of the lymphatic tissue, such as the spleen, is removed or otherwise is unavailable for invasion by the HIV-1 virus, will the course of the infection be altered, resulting in a prolonged symptom-free interval or even increased survival? The spleen of most adults with sickle cell anemia (SS) is nonfunctional due to recurrent episodes of microinfarction. If autosplenectomized SS patients are exposed to HIV-1, they may be ideal candidates to examine the question of whether absence of splenic function at the time of infection will positively alter the course of HIV-1-related disease. All SS patients with a diagnosis of HIV-1 infection at five university sickle cell centers were included in the patient cohort. Patients in active treatment or in follow-up (group A, n = 11) underwent a series of quantitative viral studies to determine their HIV-1 viral burden. The studies included the branched-DNA signal amplification assay, quantitative DNA-polymerase chain reaction (PCR), quantitative reverse transcription (RT)-initiated–PCR, and in situ PCR. All patients who died of the complications of the acquired immunodeficiency syndrome (AIDS) or of SS, lost to follow-up, or were otherwise unavailable for study (Group B: n = 7) were included in the total patient group. None of the patients in group B underwent quantitative viral studies. In addition, a control population (group C, n = 36) of HIV-1–infected African Americans without SS, of similar age and gender to the SS patients, were compared with the study population for outcomes. In eight of 11 active patients (group A), the CD4+ T-lymphocyte counts were normal and viral burdens were low for an average of 10.25 years following diagnosis. These eight patients all from group A were the only long-term nonprogressors (44%) among a total of 18 SS patients (groups A and B). In group C (control), only five patients of 36 were long-term nonprogressors (13.9%). Five patients (28%) of the total SS group (groups A and B) succumbed to AIDS. One of the five was from Group A. The evaluation of a limited number of adult individuals suggests that a significant proportion of HIV-1–seropositive SS patients (44%) may be asymptomatic long-term nonprogressors. In these patients, the CD4+ T-lymphocyte counts remained high and their viral burdens were remarkably lower than in non-SS HIV-1–seropositive individuals. Whereas this study does not prove an "autosplenectomy" hypothesis, it suggests that in patients with both SS and HIV-1 infection, the retroviral disease may be ameliorated by host factors of which absence of splenic function prior to HIV-1 infection may be one. Am. J. Hematol. 59:199–207, 1998. © 1998 Wiley-Liss, Inc.