tbuckley/cabot-search huggingface dataset:
Malignant Potential of Adenomas of Colon and Rectum
Authors: Horatio T. Enterline
Journal: JAMA (1962)

Among approximately 1,700 polyps of the large bowel and rectum removed surgically there were 61 adenomatous polyps containing carcinoma and 81 villous adenomas with and without carcinoma. In the adenomatous polyps the incidence of both atypia and invasive carcinoma rose sharply with increase in size. No lymphnode metastases were found associated with the 61 adenomatous polyps containing carcinoma, and in no instance did the lesion cause the death of the patient. However, 45 (55%) of the 81 villous adenomas contained invasive carcinoma; in 13 of the 45, the carcinoma had involved the regional nodes and in 10 instances had killed the patient. In a separate study of 666 clinically frank carcinomas, areas of adenomatous polyp were found in 6. The authors urge that all polypoid lesions be removed for definitive histologic study unless the operative risk is prohibitive.
Evidence for the release of gastric fibrinolytic activity into peripheral blood.
Authors: H T Cox, L Poller, J M Thomson
Journal: Gut (1969)

<h3>Abstract</h3> Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant mRNAs is premature polyadenylation, which can result in non-functional protein products. Translating ribosomes that encounter poly(A) sequences are terminally stalled, followed by ribosome recycling and decay of the truncated nascent polypeptide via the ribosome-associated quality control (RQC). Here, we demonstrate that the conserved RNA-binding E3 ubiquitin ligase Makorin Ring Finger Protein 1 (MKRN1) promotes ribosome stalling at poly(A) sequences during RQC. We show that MKRN1 interacts with the cytoplasmic poly(A)-binding protein (PABP) and is positioned upstream of poly(A) tails in mRNAs. Ubiquitin remnant profiling uncovers PABP and ribosomal protein RPS10, as well as additional translational regulators as main ubiquitylation substrates of MKRN1. We propose that MKRN1 serves as a first line of poly(A) recognition at the mRNA level to prevent production of erroneous proteins, thus maintaining proteome integrity.
Pharmacist Care and Clinical Outcomes for Patients With Reactive Airways Disease
Authors: Brian L. Strom
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase I Pharmacokinetic and Pharmacodynamic Study of the Farnesyl Transferase Inhibitor BMS-214662 in Combination with Cisplatin in Patients with Advanced Solid Tumors
Authors: Helen J. Mackay, Ronald Hoekstra, Ferry A. L. M. Eskens, Walker J. Loos, Donna Crawford, Maurizio Voi, Anne Van Vreckem, T. R. Jeffrey Evans, Jaap Verweij
Journal: Clinical Cancer Research (2004)

Abstract Purpose: BMS-214662 is a potent and selective inhibitor of the farnesyl transferase enzyme with in vitro and in vivo antitumor activity. The aims of this study were to characterize the toxicities and to determine the pharmacokinetic profiles of BMS-214662 when administered in combination with cisplatin, and to determine the constitutive farnesyltransferase activity as a surrogate pharmacodynamic end point. Experimental Design: Twenty-nine patients with advanced solid malignancy, refractory to conventional therapy, and with adequate hematological, renal, and hepatic function were treated with escalating doses of BMS-214662 administered as a 1-h infusion, followed after an interval of 30 min by 75 mg/m2 cisplatin administered as a 4-h infusion and repeated every 21 days. Blood and urine samples for pharmacokinetic and pharmacodynamic analyses were collected during the first cycle of treatment only. Results: Dose-limiting toxicities occurred in 4 of 9 patients enrolled at the 225 mg/m2 BMS-214662 dose cohort, and included elevation of hepatic transaminases, nausea, vomiting, diarrhea, and renal failure. There was no apparent pharmacokinetic interaction between the two drugs at the recommended dose levels, and a dose-dependent inhibition of farnesyltransferase activity was observed, which returned to control levels within 24 h of drug administration. There were no objective responses, but disease stabilization was observed in 15 patients, including 4 patients with stable disease after 6 cycles of treatment. Conclusions: A dose of 200 mg/m2 of BMS-214662 administered as a 1-h infusion with 75 mg/m2 cisplatin over 4 h is the recommended dose for additional studies.
The Fuzzy Math of Solid Tumor Stem Cells: A Perspective
Authors: Scott E. Kern, Darryl Shibata
Journal: Cancer Research (2007)

Apparently effective therapeutic agents very often fail to cure cancer patients. It is therefore attractive to wonder whether a specific resistant cell subset should be recognized and separately targeted. In solid tumors, such as carcinomas, a minor population of "cancer stem cells" has been proposed and sought experimentally in human tumors and isolated cell populations. It is often overlooked that the rationale and supportive data are essentially numerical and can be evaluated as such. A reevaluation of the published studies and related claims within awarded U.S. patents suggests that the mathematical support for the concept of therapeutically useful stem cells is weak and may even invalidate the foundations of these publications and patent claims. Mathematical arguments should be used more consistently, because they can serve as a guide for interpreting studies into cancer stem cells of solid tumors.
Ratings Game: Lists of “Top” Physicians, Hospitals Has Unclear Impact on Public
Authors: Mike Mitka
Journal: JAMA (2009)

HOSPITAL ADMINISTRATORS, PHYSIcians, and researchers may argue over the validity of quality ratings and rankings, but the fact remains that these reports are readily available to the public. How these measures affect the relationships among clinicians remains an open question. Individuals can see ratings through a variety of sources, including Thomson Reuters’ “100 Top Hospitals” report as well as on such Web sites as US News & World Report’s “America’s Best Hospitals,” Consumer Reports Health, HealthGrades, the US Centers for Medicare & Medicaid Services’ “Hospital Compare,” and the Leapfrog Group’s online hospital ratings tool. Also, some hospitals and physicians are rated locally through community media sources. David Dranove, PhD, professor of health industry management at Northwestern University’s Kellogg School of Management in Evanston, Ill, said the cynical reason such public reporting has proliferated is to sell magazines or advertising space. But he also offered a more serious explanation for why individuals may turn to these ratings and rankings. “Consumers are often uncertain about the quality of care they are receiving,” he said. “In the last decade, there has been talk about quality of care being important, but it is not guaranteed.”
A piece of my mind. Paper patients
Authors: D. G. Kardassakis
Journal: JAMA (1990)

I recently went through one of the worst experiences of my life: I took the Boards in internal medicine. It's a little like playing the medical version of "Jeopardy," only you can't change the channel, it lasts for two long September days, and instead of winning money, you have to pay the AB IM $500 for the privilege of being hazed. I arrived at the appointed location: an old army theater with laptop boards to serve as desks and a complement of officers to proctor the exam. Their rank gave authority to the standard instructions about when we could break the test seals and when we could begin. There were about 200 of us assembled—all began the day as lean, mean, test-taking machines. The exam is made up of common presentations of uncommon diseases and of uncommon presentations of common ones. The cases were often patients initially mismanaged by their
The Role of Gastric Inhibitory Polypeptide in the Augmented Insulin Response to Sucrose
Authors: James M Falko, James C Reynolds, Thomas M O'Dorisio, Brenda Bossetti, Samuel Cataland
Journal: Diabetes Care (1982)

To evaluate the role of gastric inhibitory polypeptide (GIP) in the augmented insulin response to sucrose, seven normal volunteers ingested four separate meals of 100 g sucrose (S), 50 g glucose (G), 50 g fructose (F), and 50 g glucose + 50 g fructose (G + F). Serum insulin, glucose, and GIP were measured. In each of the 3 h after sugar ingestion the integrated insulin response to (S) was greater than to (G) with the 3-h total being 104% greater. The integrated glucose response to (S) was slightly greater than to (G) in the first and second hours but the differences were not significant. Integrated GIP response to (S) was greater than to (G) in hours 2 and 3. Although significant insulin and glucose responses to (F) occurred in hour 1, G + F led to insulin and glucose responses similar to G. G + F led to greater GIP levels than G in hour 3. These studies show that GIP may play a role in the augmented insulin response to S in hours 2 and 3. This may result from delayed gastric emptying and glucose absorption. The augmentation of insulin to S in the first hour may result from fructose, extra glucose equivalent of the sucrose test solution, or from endocrine mechanisms other than those subserved by GIP.
Correction: Review of Videotapes on Endoscopy
Authors: JACK ROUTLEDGE
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 December 1984Correction: Review of Videotapes on EndoscopyJACK ROUTLEDGEJACK ROUTLEDGESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-884_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In your August issue you published a review (1) of a series of videotapes on endoscopic procedures produced by Grandview Hospital. Although I appreciate most of the criticism provided by the reviewer and the exposure that your journal provides, I would like to clarify a few points concerning our tapes.First, the correct name of our organization is Grandview Hospital and Medical Center. Although we are an osteopathic institution, "Grandview Osteopathic Hospital," as the review states, is not the appropriate name for our facility. Second, neither the review nor the list of tapes that describes the series...Reference1. KUIPER D. Endoscopic procedures series [Audiovisual review]. Ann Intern Med. 1984;101:285-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Grandview Hospital and Medical Center 405 Grand Avenue; Dayton, OH 45405 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1984Volume 101, Issue 6Page: 884-884KeywordsEndoscopyHospitals ePublished: 1 December 2008 Issue Published: 1 December 1984 PDF downloadLoading ...
Acquired Bleeding Disorders in Children, vol 3, Abnormalities of Hemostatis; vol 4, Platelet Abnormalities and Laboratory Methods
Authors: Ruth Andrea Seeler
Journal: JAMA (1982)

Volume 3 of<i>Acquired Bleeding Disorders in Children</i>is a handy, compact, up-to-date reference on a wide variety of nonhereditary bleeding problems in children. It begins with one of the best available overviews of the interaction between platelets, plasma coagulation factors, and blood vessel endothelium. Individual chapters on a range of subjects follow, including hemorrhage in the new-born, disseminated intravascular coagulation, bleeding in acute leukemia, cyanotic congenital heart disease, and liver disease. The detailed chapter on hepatocellular disease and hemostasis with 202 references is possibly more scholarly than the general reader needs. Four subjects extensively covered by publications in internal medicine and the subspecialties that are not regularly seen by the pediatrician include bleeding in patients with renal failure, immune anticoagulants, antithrombin III, and the dangers of use of the prothrombin complex concentrates. These chapters present a nicely balanced clinical overview of their respective areas. Volume 3 will have wide
Chemical profiling and histochemical analysis of Bupleurum marginatum roots from different growing areas of Hubei province
Authors: Zhitao Liang, Jian Zhang, Guangyi Yang, Hubiao Chen, Zhongzhen Zhao
Journal: Acta Pharmaceutica Sinica B (2013)

Bupleuri Radix has been widely used in traditional Chinese medicine. In the current herbal market, the species Bupleurum marginatum Wall. ex DC. is the main source of Bupleuri Radix. Although Bupleuri Radix from the roots of B. marginatum grown wild in the North West of Hubei province has higher quality compared with those from other regions according to the previous investigations, the exhaustive exploitation driven by increasing demand has drastically reduced the wild resource. As a result, germplasm evaluation and quality resource exploration are important for the sustainable utilization and cultivation of B. marginatum. A preliminary study indicated differences in the tissue structure of B. marginatum grown in different areas of North Western Hubei province. In the current study, various tissues of the roots of B. marginatum grown in different areas of North Western Hubei were subjected to laser microdissection and analyzed by microscopy and ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC–Q-TOF-MS). The results show that wild plants from Maqiao Town, Baokang County contain the most saikosaponins distributed mainly in cork, cortex and phloem. This study provides key chemical information for evaluating the quality of B. marginatum roots.
Invest in people, not restructuring
Authors: Jeffrey Braithwaite
Journal: BMJ (2005)

EDITOR—O'Dowd reports mixed views but palpable overall concern from health service managers about current proposals to merge primary care trusts.1 Some argued that such restructuring would put trusts back 18 months or more, but others thought not.

The little evidence available shows that restructuring is often futile, fails to achieve its objectives (usually, of saving money), …
ICTAL INJECTIONS IN AN EPILEPSY MONITORING UNIT (EMU) FOR BRAIN SPECT: PROBLEMS ENCOUNTERED IN ESTABLISHING THE PROGRAM AND THEIR SOLUTIONS
Authors: K. A. Grilley, L. M. Lamki, B. J. Barron, J. Wheless, J. Wilmore, O. R. Mulhern, O. F. Zeck, S. Betrand, R. Emery
Journal: Clinical Nuclear Medicine (1996)

Grilley, K.; Lamki, L. M.; Barron, B. J.; Wheless, J.; Wilmore, J.; Mulhern, O. R.; Zeck, O. F.; Betrand, S.; Emery, R. Author Information
TRAUMATIC AND OTHER AFFECTIONS OF THE KNEE-JOINT
Authors: H. A. T. Fairbank
Journal: BMJ (1930)

pr1obably depenidenit upon a locking ulp of the sepsis in some of the cellular tisstue planes of the pelvis.Cotte5 of Lyons has clainmed to obtaini miaked relief of pelvic anid abdomiinal paiii in othierwl ise intractable cases fromii a div?ision of the maini trunks of the pelvic symipathetic wh-liere they lie in front of the fifth lumbar vertebraa, anid it nmay be that witlh the aid of this procedure we hight bringi help to some of the distressing cases I have cited.This symipathectomy as desciribed by Cotte I have carried out in one case.It is simple anid apparently has no uinitowrard effects on funcetioni, and it is tlherefore specially -orthy of conisideration in those cases in wh-ich it hlas been decided in any evenit to open the abdomen-as, for example, for the per-formanice of hyster ectomy.
71 Peginterferon Alfa-2A (40KD) (PEGASYS®) in combination with ribavirin in African American and caucasian patients with chronic hepatitis C virus genotype 1: results of a multicenter study
Authors: L JEFFERS, W CASSIDY, C HOWELL, K RAJENDERREDDY, S SHERIDAN, I HO, S KHOURI, G HARB
Journal: Hepatology (2003)
How We Age: A Doctor's Journey Into the Heart of Growing Old
Authors: Ross Andel
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HYPERTROPHIC PYLORIC STENOSIS IN INFANCY
Authors: WILLIAM D. HAGGARD
Journal: JAMA (1918)

A lusty boy baby, the first born of a healthy mother with ample milk, who about the third week begins frequent regurgitant vomiting, soon becoming projectile and associated with visible peristalsis, and in whom an olive-shaped tumor may be palpated in the upper right abdomen, is almost certainly the victim of congenital pyloric stenosis. Undoubtedly there have been many infants, whose deaths were ascribed to marasmus, gastritis, inanition, etc., who really were suffering from unrecognized pyloric stenosis. Up to 1906, the mortality results of surgical intervention in former years, 53.9 per cent., were so forbidding as almost to contraindicate it in the minds of many physicians. The results are greatly improved by substituting simple pyloroplasty, Rammstedt's operation (1912), or the operation of Strauss (1914) for gastro-enterostomy. The operation may be done in less than half the time required for a gastro-enterostomy and with nearly one half the mortality, that is,
Medicine in Saigon
Authors: Joseph F. Fazekas
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
397. AAV-Mediated Gene Transfer to Endothelial Cells
Authors: Mo-Ying Hsieh, Yi-Lin Liu, Alexander Schlachterman, Katherine A. High
Journal: Molecular Therapy (2005)

Adeno-associated virus (AAV) vectors have been evaluated in clinical studies of gene transfer for hemophilia by two different strategies, one using liver as the target tissue and the other using skeletal muscle. Both routes have resulted in long-term cures in hemophilic dogs. In humans, delivery to skeletal muscle resulted in long-term expression but at sub-therapeutic levels, while the liver-targeted study raised expression to therapeutic levels at the highest dose, although duration of expression was only short-lived (<10 weeks). Moreover, the high prevalence of hepatitis in the adult hemophilia population limits the utility of liver as a target tissue in practice. Therefore we investigated the possibility of targeting other cell types. Endothelial cells (ECs) are of interest because of their easy accessibility and the direct secretion of transgene product into the circulation.
Frank Samuel Preston
Authors: W M DIXON
Journal: BMJ (2003)

After house jobs Frank joined the Royal Navy, serving on aircraft carriers in the Far East. This experience forged his fascination with aviation medicine. On demobilisation he joined the Royal Naval Volunteer Reserve, rising to the rank of surgeon captain, which led to his appointment as honorary physician to the Queen.​Queen.




Figure 1




Following a brief dalliance with anaesthetics Frank opted for a career in occupational medicine, joining British European Airways (BEA), as it then was, as a junior medical officer with responsibilities for, among other things, aircrew health and safety. At a time of enormous expansion and technical development in air travel he embraced the health problems of both aircrew and passengers on long distance and high altitude flights and became an international authority on aviation medicine. Rising steadily through the hierarchy at British Airways he was finally appointed director of medical services, retiring in 1988.

During his career with BA he was seconded to the Concorde project in Toulouse to assess the possible effects of cosmic radiation and other hazards of high altitude on commercial flights. His applied research work also dealt with the more mundane problems of long distance travel, including the effects of time zone and climate changes, the incidence of food poisoning, the need for multiple immunisation, the frequency and duration of rest periods, the internal environment of aircraft, and the effects of ageing, injury, and illness on pilot performance. In these situations he was ever the pilots' friend, seeking to reduce stress, to improve performance, and to ease retirement, if that became necessary.

He travelled widely, visiting almost every country in the world and was as well known in aeronautical circles in Bangkok or Sydney as he was in Washington or Paris. In the United States he was vice president of the International Academy of Aviation and Space Medicine and a fellow of the Aerospace Medical Association. He was also elected a fellow of the Royal Aeronautical Society—an uncommon honour for a medical man.

He leaves a wife, Margaret; one son; and two daughters.

Frank Samuel Preston, former director of medical services British Airways (b Glasgow 1923; q Glasgow 1947; OBE, VRD, FFOM) died from carcinomatosis on 14 August 2003.