Acute Hepatitis E Virus Infection in an HIV-Infected Person in the United States
Authors: Jennifer A. Curry
Journal: Annals of Internal Medicine (2009)

Letters3 February 2009Acute Hepatitis E Virus Infection in an HIV-Infected Person in the United StatesJennifer A. Curry, MD, Nehkonti Adams, MD, and Nancy F. Crum-Cianflone, MD, MPHJennifer A. Curry, MDFrom Naval Medical Center, San Diego, CA 92134, and Uniformed Services University of Health Sciences, Bethesda, MD 20814., Nehkonti Adams, MDFrom Naval Medical Center, San Diego, CA 92134, and Uniformed Services University of Health Sciences, Bethesda, MD 20814., and Nancy F. Crum-Cianflone, MD, MPHFrom Naval Medical Center, San Diego, CA 92134, and Uniformed Services University of Health Sciences, Bethesda, MD 20814.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-3-200902030-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Hepatitis E virus (HEV) is an enterically transmitted cause of viral hepatitis that is rarely noted without international travel.Objective: To report the first case of an HIV-infected man with acute hepatitis due to HEV infection who had not traveled outside the United States.Case Report: A 45-year-old HIV-positive man had mildly elevated aminotransferase levels that were asymptomatic. He had a CD4 cell count of 0.36 × 109 cells/L (31%) with undetectable HIV RNA (<50 copies/mL) while receiving abacavir–lamivudine, atazanavir, and ritonavir. He had visited Maine and Illinois 4 weeks previously but reported no exposure to sick persons, nonmunicipal water, or ...References1. Amon JJ, Drobeniuc J, Bower WA, Magaña JC, Escobedo MA, Williams IT, et al. Locally acquired hepatitis E virus infection, El Paso, Texas. J Med Virol. 2006;78:741-6. [PMID: 16628579] CrossrefMedlineGoogle Scholar2. Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engle RE, et al. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol. 2002;40:117-22. [PMID: 11773103] CrossrefMedlineGoogle Scholar3. Balayan MS, Fedorova OE, Mikhailov MI, Rytick PG, Eremin VF, Danilova TI, et al. Antibody to hepatitis E virus in HIV-infected individuals and AIDS patients. J Viral Hepat. 1997;4:279-83. [PMID: 9278226] CrossrefMedlineGoogle Scholar4. Montella F, Rezza G, Di Sora F, Pezzotti P, Recchia O. Association between hepatitis E virus and HIV infection in homosexual men [Letter]. Lancet. 1994;344:1433. [PMID: 7968090] CrossrefMedlineGoogle Scholar5. Kamar N, Selves J, Mansuy JM, Ouezzani L, Péron JM, Guitard J, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med. 2008;358:811-7. [PMID: 18287603] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jennifer A. Curry, MD; Nehkonti Adams, MD; Nancy F. Crum-Cianflone, MD, MPHAffiliations: From Naval Medical Center, San Diego, CA 92134, and Uniformed Services University of Health Sciences, Bethesda, MD 20814.Note: The opinions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Departments of the Army, Navy, or Air Force or the Department of Defense. The authors have no commercial or other association that might pose a conflict of interest in this work. This work is original and has not been published elsewhere.Grant Support: By the Infectious Disease Clinical Research Program (IDCRP), Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, of which the TriService AIDS Clinical Consortium is a component. The IDCRP is a Department of Defense tri-service program executed through USUHS and the Henry M. Jackson Foundation for the Advancement of Military Medicine in collaboration with the Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases/Department of Conservation and Recreation through Interagency Agreement HU0001-05-2-0011.Disclosures: None disclosed. 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