Serum Uric Acid Concentration Among Business Executives
Authors: Henry J. Montoye, John A. Faulkner, Horace J. Dodge, William M. Mikkelsen, Park W. Willis, Walter D. Block
Journal: Annals of Internal Medicine (1967)

Article1 May 1967Serum Uric Acid Concentration Among Business ExecutivesWith Observations on Other Coronary Heart Disease Risk FactorsHENRY J. MONTOYE, PH.D., JOHN A. FAULKNER, PH.D., HORACE J. DODGE, M.D., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., PARK W. WILLIS III, M.D., F.A.C.P., WALTER D. BLOCK, PH.D.HENRY J. MONTOYE, PH.D.Search for more papers by this author, JOHN A. FAULKNER, PH.D.Search for more papers by this author, HORACE J. DODGE, M.D.Search for more papers by this author, WILLIAM M. MIKKELSEN, M.D., F.A.C.P.Search for more papers by this author, PARK W. WILLIS III, M.D., F.A.C.P.Search for more papers by this author, WALTER D. BLOCK, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-838 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHistorians have noted what appears to be an increased prevalence of gout among distinguished men of genius and accomplishment (1, 2). Furthermore, Cobb and his associates (3-5) have presented evidence that business executives, mostly in the middle management level, had significantly higher levels of serum uric acid than craftsmen. There was a tendency among craftsmen for serum uric acid to be positively related to years of education. It was also reported that medical students, who aspire to a high social level, tended to have high serum uric acid concentrations. There was no significant correlation between serum uric acid concentration and...References1. STETTEN D: Gout. Perspect. Biol. Med. 2: 185, 1959. CrossrefMedlineGoogle Scholar2. COPEMAN WS: A Short History of the Gout and Rheumatic Diseases. The University of California Press, Berkeley and Los Angeles, 1964. CrossrefGoogle Scholar3. COBBDUNNBROOKSRODNAN SJPGGP: Serum urate levels in males by social class. Arthritis Rheum. 4: 412, 1961. Google Scholar4. DUNNBROOKSMAUSNERRODNANCOBB JPGWJGPS: Social class gradient of serum uric acid levels in males. JAMA 185: 431, 1963. CrossrefGoogle Scholar5. COBB S: Hyperuricemia in executives, in The Epidemiology of Chronic Rheumatism, edited by KELLGREN, J. H., JEFFREY, M. R., BALL, J. F. A. Davis Co., Philadelphia, 1963, pp. 182-188. Google Scholar6. BROOKSMUELLER GWE: Serum urate concentrations among university professors: relation to drive, achievement and leadership. JAMA 195: 415, 1966. CrossrefMedlineGoogle Scholar7. FRANCIS T: Aspects of the Tecumseh study. Public Health Rep. 76: 963, 1961. CrossrefMedlineGoogle Scholar8. MONTOYEEPSTEIN HJFH: Tecumseh community health study: an investigation of health and disease in an entire community. J. Sport Med. 5: 127, 1965. Google Scholar9. NAPIER JA: Field methods and response rates in the Tecumseh community health study. Amer. J. Public Health 52: 208, 1962. CrossrefGoogle Scholar10. EPSTEIN FH: An epidemiological study in a total community: the Tecumseh project. Univ. Mich. Bull. 26: 307, 1960. Google Scholar11. MIKKELSENDODGEVALKENBURG WMHJH: The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia: Tecumseh, Michigan 1959-1960. Amer. J. Med. 39: 242, 1965. CrossrefMedlineGoogle Scholar12. LIDDLESEEGMILLERLASTER LJEL: The enzymatic spectrophotometric method for determination of uric acid. J. Lab. Clin. Med. 54: 903, 1959. MedlineGoogle Scholar13. Autoanalyzer Method for Serum Uric Acid Determination. Technicon Laboratory, Technicon Instruments Corp., Chauncey, N. Y., 1963. Google Scholar14. ABELLLEVYBRODICKENDALL LLBBBBFE: A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. Chem. 195: 357, 1952. CrossrefMedlineGoogle Scholar15. Autoanalyzer Method for Serum Cholesterol Determination. Technicon Bulletin N24 P. Technicon Instruments Corp., Chauncey, N. Y., 1963. Google Scholar16. REIFFMONTOYEREMINGTONNAPIERMETZNEREPSTEIN GGHJRDJAHLFH: Assessment of physical activity by questionnaire and interview, in Physical Activity and the Heart. Charles C Thomas, Publisher, Springfield, Ill., 1967, pp. 336-371. Google Scholar17. MONTOYEEPSTEINKJELSBERG HJFHMO: The measurement of body fatness: a study in a total community. Amer. J. Clin. Nutr. 16: 417, 1965. CrossrefMedlineGoogle Scholar18. DODGEMIKKELSEN HJWM: The relationship of serum uric acid scores to occupation, smoking and drinking habits in Tecumseh, Michigan, 1959-1960. Presented at the Annual Meeting, American Public Health Association, New York City, Oct. 9 1964. Google Scholar19. PELLD'ALONZO SCA: Blood pressure, body weight, serum cholesterol, and smoking habits among executives and nonexecutives. J. Occup. Health 3: 467, 1961. Google Scholar20. MIKKELSEN WM: The possible association of hyperuricemia and/or gout with diabetes mellitus. Arthritis Rheum. 8: 853, 1965. CrossrefMedlineGoogle Scholar21. GERTLERGARNLEVINE MMSMSA: Serum uric acid in relation to age and physique in health and coronary heart disease. Ann. Intern. Med. 34: 1421, 1951. LinkGoogle Scholar22. OBERMANLANEMITCHELLGRAYBIEL ANEREA: The Thousand Aviator Study: Distributions and Intercorrelations of Selected Variables. Monograph 12. U. S. Naval Aerospace Medical Institute, Pensacola, Fla., 1965. CrossrefGoogle Scholar23. LEESCHNEIDER RERF: Hypertension and arteriosclerosis in executive and nonexecutive personnel. JAMA 167: 1447, 1958. CrossrefMedlineGoogle Scholar24. DAWBER TR: Coronary heart disease. Bibl. Cardiol. 13: 9, 1963. Google Scholar25. BRECKENRIDGE A: Hypertension and hyperuricemia. Lancet 1: 15, 1966. CrossrefMedlineGoogle Scholar26. STETTEN D: On the metabolic defect in gout. Bull. N. Y. Acad. Med. 28: 664, 1952. MedlineGoogle Scholar27. MOOREWEISS CBTE: Uric acid metabolism and myocardial infarction, in The Etiology of Myocardial Infarction, edited by JAMES, T. N., KEYES, J. W. Little, Brown and Co., Boston, 1963, chap. 29. Google Scholar28. KOHNPROZAN PMGB: Hyperuricemia—relationship to hypercholesterolemia and acute myocardial infarction. JAMA 170: 1909, 1959. CrossrefMedlineGoogle Scholar29. WEISSSEGALOFFMOORE TEAC: Gout and diabetes. Metabolism 6: 103, 1957. MedlineGoogle Scholar30. MARINOFFLEMPERTMANDEL SCPEE: Association of hypercholesterolemia with hyperuricemia: a review of the literature. Chicago Med. Sch. Quart. 22: 135, 1962. MedlineGoogle Scholar31. SALVINIVERDI LG: Statistical study on correlation between blood level of cholesterol, beta/alpha lipoprotein ratio and uric acid of normal and arteriosclerotic subjects. Gerontologia (Basel) 3: 327, 1959. CrossrefMedlineGoogle Scholar32. GERTLEROPPENHEIMER MB: Serum uric acid levels in men and women past the age of 65 years. J. Geront. 8: 465, 1953. CrossrefMedlineGoogle Scholar33. SCHOENFELDGOLDBERGER MRE: Serum cholesterol uric acid correlations. Metabolism 12: 714, 1963. MedlineGoogle Scholar34. BERKOWITZ D: Blood lipid and uric acid inter-relationships. JAMA 190: 856, 1964. CrossrefMedlineGoogle Scholar35. LIEBERJONESLOSOWSKYDAVIDSON CSDPMSCS: Interrelation of uric acid and ethanol metabolism in man. J. Clin. Invest. 41: 1863, 1962. CrossrefMedlineGoogle Scholar36. MONTOYEHOWARDWOOD HJGEJH: Observations of some hemochemical and anthropometric measurements in athletes. J. Sport Med. In press. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the Department of Physical Education, School of Education, and the Department of Epidemiology, School of Public Health, University of Michigan; and the Rackham Arthritis Research Unit, Department of Internal Medicine, Department of Dermatology, and Heart Station, University of Michigan Medical Center, Ann Arbor, Mich.This study was supported by the Cardiovascular Research Center, University of Michigan, under program project grant HE-6378, the National Heart Institute, National Institutes of Health, Bethesda, Md., by the Horace H. Rackham Research Fund, and by the Michigan Heart Association, Detroit, Mich.Requests for reprints should be addressed to Henry J. Montoye, Ph.D., Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Mich. 48104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUric acid and central nervous system functioning (a literature review)Correlates of uric acid and its association with asymptomatic carotid atherosclerosis: The ARIC studyHigh uric acid: A metabolic marker of coronary heart disease among alcohol abstainers?GoutRelationship Between Blood Uric Acid Level and Personality TraitsAn Epidemiologic Study on the Correlation Between Salt Threshold, Academic Test Marks, Biochemical Data, Number of Complaints, and Personality in Women College StudentsBlood Uric Acid Level and IQ: A Study in Twin FamiliesSerum uric acid and coronary heart diseasePlasma and urine uric acid levels: Heritability estimates and correlation with IQUse of the Uricase-Inhibited Rat as an Animal Model in ToxicologyEpidemiology of serum uric acid among 8000 Japanese-American men in HawaiiSerum uric acid: Its association with other risk factors and with mortality in coronary heart diseaseThe Epidemiology of Hyperuricemia and GoutCardiovascular fitness in a selected group of dentistsAre there any Promising Biochemical Correlates of Achievement Behavior and Motivation? The Evidence for Serum Uric Acid and Serum CholesterolRelation of weight change to changes in atherogenic traits: The Framingham studyLIST OF REFERENCESA Multi-Disciplinary Catalogue of Uric Acid Literature of Interest to Behavioural ScientistsSerum Urate in Healthy Men — Intermittent Elevations and Seasonal EffectBlood uric acid in executivesComparative Cardiovascular Adaptation to Exercise in Animals and Man and its Relevance to Coronary Heart DiseaseAkute Wirkung von Nicotin auf die Serumkonzentration und renale Ausscheidung von HarnsäureSERUM URATE LEVELS AND GOUT IN AUSTRALIAN MALESOccult Mood in Musculoskeletal DiseasesNineteenth rheumatism review. Part-IIIClinical survey of 354 patients with gout.Angiography of the Spinal Cord and CanalReferencesReduction of serum uric acid in young men during physical trainingBODY-WEIGHT, ABO BLOOD-GROUPS, AND ALTITUDE OF DOMICILE AS DETERMINANTS OF SERUM-URIC-ACID IN MILITARY RECRUITS IN FOUR COUNTRIESSerum urate concentrations in the Australian aboriginal.Physical characteristics and exercise performance of pedicab and upper socioeconomic classes of middle-aged Chinese menChapter 17. Atherosclerosis 1 May 1967Volume 66, Issue 5Page: 838-850KeywordsAttentionCholesterolEpidemiologyGoutHeartLongitudinal studiesMedical educationPrevention, policy, and public healthResearch fundingUric acid Issue Published: 1 May 1967 PDF DownloadLoading ...