Light-chain Disease
Authors: RALPH C. WILLIAMS
Journal: Annals of Internal Medicine (1966)

Article1 September 1966Light-chain DiseaseAn Abortive Variant of Multiple MyelomaRALPH C. WILLIAMS JR., M.D., RICHARD D. BRUNNING, M.D., FRANK A. WOLLHEIM, M.D.RALPH C. WILLIAMS JR., M.D.Search for more papers by this author, RICHARD D. BRUNNING, M.D.Search for more papers by this author, FRANK A. WOLLHEIM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-471 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty-one per cent of 110 myeloma patients studied showed relative hypogammaglobulinemia by ordinary electrophoresis. Nine of ten living patients showed marked elevations of free serum L-chains (see Table 1) predominantly of one major L-chain type. Myeloma patients with sharp serum M-components also showed free serum L-chains and in 11%, concentrations of the same order of magnitude as was the case in the hypogammaglobulinemic patients. Attempts to detect the presence of small quantities of whole 7S myeloma protein by Gm character, immunologic deficiency, or H-chain subgrouping of gamma globulin fractions of hypogammaglobulinemic sera were generally unsuccessful. Two of ten patients studied...References1. WALDENSTRÖM J: Monoclonal and polyclonal gammopathies and the biological system of gamma globulins. Progr. Allerg. 6: 320, 1962. MedlineGoogle Scholar2. HEREMANSLAURELLMÅRTENSSONHEREMANSLAURELLSJOQUISTWALDENSTRÖM JFAHLMCBJJ: Studies on "abnormal" serum globulins (M-components) in myeloma, macroglobulinemia and related diseases. Acta Med. Scand. 170 (suppl. 367): 1, 1961. MedlineGoogle Scholar3. OSSERMANTAKATSUKI EFK: Plasma cell myeloma: gamma globulin synthesis and structure. 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Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Arthritis Unit, Department of Medicine, and Department of Laboratory Medicine, University of Minnesota, Minneapolis, Minn.This study was supported in part by grant AM 07372, U. S. Public Health Service, Bethesda, Md., and by a grant from the Minnesota Arthritis Foundation.Requests for reprints should be addressed to Ralph C. Williams, Jr., M.D., Box 442, University Hospital, Minneapolis, Minn. 55455. 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INCLUDING DATA FROM A THERAPEUTIC TRIAL CONDUCTED BY A MEDICAL RESEARCH COUNCIL WORKING PARTYDefective (incomplete) synthesis of immunoglobulin heavy polypeptide chains as the cause of a myeloma-like diseaseImmunofluorescent studies of the myeloma kidney with special reference to light chain diseaseDetection of Bence Jones ProteinuriaStudies of Monoclonal Immunoglobulins (M-Components) in Various KindredsRALPH C. WILLIAMS JR., M.D., JEFFREY L. ERICKSON, B.A., HERBERT F. POLESKY, M.D., WILLIAM R. SWAIM, M.D.Die paraproteinämischen HämoblastosenGamma-globulins, antibodies, and myeloma proteins 1 September 1966Volume 65, Issue 3Page: 471-486KeywordsArthritisAttentionGlobulinsMedical servicesMyelomaProteinsResearch laboratories Issue Published: 1 September 1966 PDF downloadLoading ...