tbuckley/cabot-search huggingface dataset:
Consequences of Pressure Overload on Sarcomere Protein Mutation-Induced Hypertrophic Cardiomyopathy
Authors: Joachim P. Schmitt, Christopher Semsarian, Michael Arad, Joseph Gannon, Ferhaan Ahmad, Catherine Duffy, Richard T. Lee, Christine E. Seidman, J.G. Seidman
Journal: Circulation (2003)

Whether ventricular remodeling from hypertrophic cardiomyopathy (HCM), systemic hypertension, or other pathologies arises through a common signaling pathway or through independent molecular mechanisms is unknown. To study this, we assessed cardiac hypertrophy in a mouse model of HCM subjected to increased left ventricular (LV) load.Transverse aortic banding of mice with or without an Arg403Gln cardiac myosin heavy chain mutation (alphaMHC403/+) produced similarly elevated LV pressures (120+/-30 versus 112+/-14 mm Hg; P=NS). No mice developed heart failure, and mortality (26% alphaMHC403/+, 35% wild-type) was comparable. Load-induced hypertrophy was identical in banded 129SvEv alphaMHC403/+ mice (LV anterior wall [LVAW]=1.28+/-0.11) and 129SvEv wild-type mice (LVAW=1.29+/-0.11 mm; P=NS). Genetically outbred Black Swiss (BS) alphaMHC403/+ mice showed only mildly exaggerated hypertrophy in response to aortic banding (BS alphaMHC403/+ LVAW=1.30+/-0.13 mm; BS wild-type LVAW=1.17+/-0.15 mm; P=0.03), suggesting some effect from a BS genetic locus that modifies hypertrophy induced by the cardiac MHC Arg403Gln mutation. Histopathology and molecular markers of hypertrophy were comparable in all banded 129SvEv or BS mice. Banded alphaMHC403/+ mice had potential for greater hypertrophy, because cyclosporin A treatment markedly augmented hypertrophy.The uniform hypertrophic response to increased ventricular load in wild-type and alphaMHC403/+ mice indicates independent cardiac remodeling pathways and predicts that coexistent hypertension and HCM should not profoundly exacerbate cardiac hypertrophy. In contrast, sarcomere mutation and cyclosporin A-mediated calcineurin inhibition stimulate a shared hypertrophic signaling pathway. Defining distinct signaling pathways that trigger myocyte growth should help to tailor therapies for cardiac hypertrophy.
Abord psychothérapique des mères célibataires dans le cadre des hotels maternels
Authors: M. de Senarclens, J.-D. Stucki
Journal: Psychotherapy and Psychosomatics (1972)

Multidisciplinary research on a number of unmarried mothers who, since the delivery, chose to live with their child in homes called 'Hotels Maternels', where great attention is given to a good psychological environment and best care to the baby. The clinical observation (medical, psychological tests etc.) has been devoted to the somatic and psychoaffective development of the offspring from birth to school age; the investigation on the mother concerns her personality, emotional state and psychiatric pathology. Special consideration is given to mother-child relationship. The aim is to appreciate the chances of a good social integration for the mother and the baby as well as the effect of good care for both. The first results of the research show no gross maternal psychiatric pathology, but clearly indicate that a lonely motherhood represents a transitional state with ambivalence and feelings of incompleteness very much like those experienced by a married woman living existential or personal difficulties.
Abstract 3440: Cell-based screening identify gene expression signature correlated with sensitivity to an MEK1/2 inhibitor
Authors: Jing Zhang
Journal: Cancer Research (2014)

Abstract The mitogen-activated extracellular signal-regulated kinase (MEK) family is one of the key kinase regulators involved in tumor oncogenic growth and progression. Multiple MEK inhibitors are currently under clinical investigation for cancer treatment and more agents targeting MEK are under preclinical development. The mechanisms underlying resistance to MEK inhibitor are unclear. Here we examined the anti-proliferation activity of a new small molecule MEK inhibitor in a panel of cell lines harboring either ras or raf mutation. We found 23 lines that are sensitive to the inhibitor and 24 lines are resistant. We compared gene expression by Affymetrix U219 arrays and gene copy number by Affymetrix SNP6.0 arrays in these two cell line groups. With a p-value cutoff set at0.01, we identified 549 genes differentially expressed and 328 genes demonstrated different copy numbers between the two groups. 23 genes were both detected by gene expression profiling and gene copy number data. These genes include MEK family members MAP2K3 and MAP2K7, as well as other important molecule markers in cancer biology, including PIK3R2 and BRCA2. The results suggested a potential genomic signature that could be predictive of response to the MEK inhibitor in vitro. Further investigation and validation in patient-derived xenograft (PDX) models will undoubtfully provide valuable information for selecting patients that are likely to receive clinical benefit. Citation Format: Jing Zhang. Cell-based screening identify gene expression signature correlated with sensitivity to an MEK1/2 inhibitor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3440. doi:10.1158/1538-7445.AM2014-3440
Therapeutic Theophylline Levels and Adverse Cardiac Events
Authors: Michael Shannon
Journal: Annals of Internal Medicine (1994)

Letters15 May 1994Therapeutic Theophylline Levels and Adverse Cardiac EventsMichael Shannon, MD, MPHMichael Shannon, MD, MPHChildren's Hospital; Harvard Medical School; Boston, MA 02115Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-10-199405150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Raggi's comments on the potential for normally therapeutic theophylline levels to produce significant cardiac disturbances. This risk has been reported by many investigators. In a separate study, Bittar and colleagues [1] reported that among elderly patients receiving theophylline, those with serum concentrations between 10 and 20 mg/L had an 3.7-fold greater risk for cardiac disturbances than did patients of similar age with nondetectable serum theophylline concentrations. In an in vitro study, Lin and coworkers [2] found that theophylline has specific arrhythmogenic effects on human atrial tissue. Although their data suggest that theophylline has direct actions ...References1. Bittar G, Friedman HS. The arrhythmogenicity of theophylline. A multivariate analysis of clinical determinants. Chest. 1991; 99:1415-20. Google Scholar2. Lin CI, Chuang IN, Cheng KK, Chiang BN. Arrhythmogenic effects of theophylline in human atrial tissue. Int J Cardiol. 1987; 17:289-97. Google Scholar3. Sessler CN, Cohen MD. Cardiac arrhythmias during theophylline toxicity. A prospective continuous electrocardiographic study. Chest. 1990; 98:672-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Children's Hospital; Harvard Medical School; Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1994Volume 120, Issue 10Page: 891KeywordsAttentionBlood plasmaCatecholaminesCoronary arteriesDepolarizationDrugsElderlyIntoxicationOxygenRisk management ePublished: 15 August 2000 Issue Published: 15 May 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Validation of the Harvard Six Cities Study of Particulate Air Pollution and Mortality
Authors: Daniel Krewski, Richard T. Burnett, Mark S. Goldberg, Kristin Hoover, Jack Siemiatycki, Michael Abrahamowicz, Warren H. White
Journal: New England Journal of Medicine (2004)

To the Editor: In a 16-year prospective cohort study of six cities in the northeastern and midwestern United States beginning in the 1970s, Dockery et al.1 reported that long-term exposure to ambient fine particles (with an aerodynamic diameter of 2.5 μm) was positively associated with both overall mortality and mortality from cardiopulmonary causes. Because the Harvard Six Cities Study played a pivotal and controversial role2–6 in the establishment of the current U.S. objective for ambient air quality with respect to fine particles,7 the Environmental Protection Agency, industry, and nongovernmental organizations called for an independent reanalysis of this study to . . .
Iatrogenic pulmonary artery pseudoaneurysm: images from different modalities
Authors: A S McQueen, L Mitchell, M Muller, G MacGowan, P Corris
Journal: Thorax (2008)

Iatrogenic pulmonary artery pseudoaneurysm: images from different modalitiesA 68-year-old woman was referred for investigation of pulmonary artery hypertension.Right heart catheterisation was performed and the tip of the catheter was positioned in the right middle lobe pulmonary artery under fluoroscopic guidance.A Swan-Ganz balloon was inflated to record a pressure of 78/23 mm Hg (mean 42 mm Hg).Immediately after the balloon was inflated, the patient experienced small volume haemoptysis.A CT pulmonary angiogram was performed later the same day to investigate the cause of her pulmonary artery hypertension.This showed a 3 cm pseudo-aneurysm arising from a right middle lobe subsegmental pulmonary artery with associated pulmonary haemorrhage (fig 1).The patient remained haemodynamically stable and was scheduled for elective embolisation of the pseudo-aneurysm.Before this, cardiac MRI was performed (6 days after catheterisation) to assess right ventricular dimensions, allowing the opportunity to visualise the pseudoaneurysm on the MRI scan (fig 2).A catheter angiogram was performed the following day with embolisation of the inflow artery by uncoated platinum coils (fig 3).
Does This Dizzy Patient Have a Serious Form of Vertigo? Comment and Correction-Reply
Authors: David A. Froehling
Journal: JAMA (1994)

In Reply.  —We appreciate the comments by Dr Warr regarding the study by Herr et al. 1 In reviewing the published literature on dizziness, we found only a few articles that addressed the accuracy of the history and physical examination in categorizing the various causes of dizziness and many of these had limitations.  The sensitivity and specificity of the history and physical examination findings in the evaluation of a patient with dizziness and vertigo depend on the physician's knowledge, experience, and skill. The positive and negative predictive value of the history and physical examination also depends on the prevalence of disease in the medical setting in which the patients are evaluated. In Table 3 of the article, we reported that the negative predictive value of a cluster of specific history and examination findings was 88% for serious causes of dizziness.  Dr Warr's comments about the comfort threshold and decision making
Nonvisualization of a Sentinel Lymph Node on Lymphoscintigraphy Requiring Reinjection of Sulfur Colloid in a Patient With Breast Cancer
Authors: Christine B. Teal, Rachel F. Brem, Jocelyn A. Rapelyea, Esma A. Akin
Journal: Clinical Nuclear Medicine (2008)

The injection techniques and use of lymphoscintigraphy for sentinel lymph node (SLN) biopsy in breast cancer patients vary. Some do not advocate routine use of lymphoscintigraphy. The purpose of this case report is to illustrate when lymphoscintigraphy should be used.At our institution, we use periareolar intradermal injections of 0.6 mCi Tc-99m sulfur colloid followed by lymphoscintigraphy with reported identification rates greater than 99%. The only patient in our series who did not have a SLN identified had presented after excisional biopsy of an upper outer quadrant cancer. We report the case of another patient who presented after excision of an upper outer quadrant invasive ductal carcinoma and had no evidence of lymphatic drainage on lymphoscintigraphy after the periareolar injections of radioisotope.Additional injections of 0.4 mCi Tc-99m sulfur colloid were performed lateral to the incision in the upper outer quadrant. On lymphoscintigraphy a SLN was visualized and was subsequently successfully identified intraoperatively.This case report supports the value of lymphoscintigraphy for successful identification of a SLN in a patient with prior surgery. We therefore recommend imaging patients who have had prior breast surgery, particularly excisions in the upper outer quadrant.
Case of Cataract Occurring in Early Life
Authors: A. Prichard
Journal: BMJ (1847)

On Tuesday, the 17th of August, two stone opera- tions took place at the Lowestoft Infirmary, one patient was a boy, 8 years old, the other a female, aged 19, from the neighbourhood of Cromer.As the calculus removed from the female was of rather large dimen- sions, and accomplished with great facility by means of dilatation, I am induced cursorily to notice the case in your Journal.Many of our best surgeons are divided in opinion as to the sait mode of extracting calculi from the female bladder.There are some who deem an incision the best practice, and who assert that the use of the knife is less frequently followed by incontinence of urine than when dilatation is employed.Stone in the;female bladder not being of frequent occurrence, experience doesnot permit me to offer a decided opinion on the subject.I am enabled, howevet, to' state, that in a couversation which I had the ptivilege of holding with Mr. Crosse, of Norwich, a few days after the operation, le informed me he had had.repeated experience of both ways of proceeding to relieve a female patient of stone in the bladder; and that he was fixed in the opinion that dilating is to be preferred to incision, when the calculus is of moderate size, and even when the size of the foreign body cannot be satis- factorily estimated, or is believed to be large, he prefers commencing by the dilating process, until the finger can be freely admitted into the bladder, when cutting can then be practised to the extent required.The dilatation, he moreover remarked, should be effected
Cooler Heads (of State) Prevail... Voilà, French-American HIV Test Accord
Authors: Charles Marwick
Journal: JAMA (1987)

TOO MANY VOICES with too little authority thwarted resolution of the French-American dispute over the identification of the virus now known as the cause of the acquired immunodeficiency syndrome (AIDS) for more than 12 months. The legal case involved patent rights for the virus antibody test, alleged breach of contract, and other issues. Only after intervention at the highest levels of the American and French governments was the Tower of Babel silenced and amity ultimately achieved. Within days of quieting the numerous official and nonofficial would-be participants, two individuals, representing the two disputing parties, met. They agreed on the course of action they would pursue. A little more than two months later, after a whole year of fruitless legal and scientific wrangling, an agreement was reached that satisfied both sides. The speed with which an acceptable agreement was reached once the disputants agreed to appoint a single reprosentative for each
Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought conditions
Authors: Yusaku Uga, Kazuhiko Sugimoto, Satoshi Ogawa, Jagadish Rane, Manabu Ishitani, Naho Hara, Yuka Kitomi, Yoshiaki Inukai, Kazuko Ono, Noriko Kanno, Haruhiko Inoue, Hinako Takehisa, Ritsuko Motoyama, Yoshiaki Nagamura, Jianzhong Wu, Takashi Matsumoto, Toshiyuki Takai, Kazutoshi Okuno, Masahiro Yano
Journal: Nature Genetics (2013)
THE CLINICAL USEFULNESS OF NUCLEAR IMAGING IN PATIENTS UNDERGOING PARATHY-ROIDECTOMY
Authors: R. J. Gorten, R. E. Millis, G. L. Jackson
Journal: Clinical Nuclear Medicine (1992)

S: APRIL 9–12, 1992 San Antonio Convention Center & Hyatt Regency Hotel SAN ANTONIO, TEXAS Southwestern Chapter Society of Nuclear Medicine SPECT/PET Nuclear Cardiology Symposium and 37th Annual Meeting: PDF Only
?-thalassemia trait might increase the severity of hemochromatosis in subjects with the C282Y mutation in the HFE gene
Authors: Valder R. Arruda, Marcela F. Agostinho, Rodolfo Can�ado, Fernando F. Costa, Sara T.O. Saad
Journal: American Journal of Hematology (2000)

With the C282Y Mutation in the HFE GeneTo the Editor: The association between hereditary hemochromatosis and thalassemia syndrome might lead to a severe iron overload [1,2], but the results are still controversial.By PCR and restriction enzyme digestion [3], we analyzed the C282Y and H63D mutations in the HFE gene in one family whose propositus carried the ␤-thalassemia trait.The patient was a female, 38 years old, presenting weakness and arthralgia.She had 4 children and received transfusion (1 unit of red cell) during her last gestation.She did not present diabetes or cardiac disease and her hepatic enzymes were normal.Her mother and 2 sons also carried the ␤-thalassemia trait.
Hemothorax Complicating Translumbar Aortography
Authors: Esmond Braun
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The translumbar method of abdominal aortography is advocated by Leadbetter and Markland<sup>1</sup>for renal artery studies, and their compilation of experience shows relatively few serious complications. Perhaps the commonest complication is hemorrhage, which is usually self-limited, manifested as a retroperitoneal hematoma noted subsequently at surgery, and rarely of any magnitude. However, retroperitoneal dissection and exsanguination may develop. Presented here is a most unusual hemorrhagic complication, that of massive bleeding into the chest. A 38-year-old Negro male was under investigation for arterial hypertension (180/110 Hg mm) of recent origin. The intravenous pyelogram, regitine test, and total and differential renal function studies were normal. Under epidural anesthesia, an 18-gauge needle was passed through the left flank and into the aorta on the first attempt. A 5 cc test dose of 50% sodium diatrizoate was injected and the films examined for needle placement, which was deemed satisfactory. The second
It's Over, Debbie
Authors: Peter A. Singer
Journal: JAMA (1988)

<h3>To the Editor.</h3> —The article<sup>1</sup>in which a gynecology resident describes how he injected a patient with a fatal overdose of morphine begs the question: What's over? Debbie's life is over. Also over, however, is the tenet that killing is an act that our society finds abhorrent. That the resident could kill a patient, let alone one whom he did not know or with whom he had no relationship, represents a breach of any semblance of medical ethics and the rule of law. That<i>JAMA</i>could publish this cavalier description of homicide, however, bespeaks a social milieu that is tolerant to the killing of patients by physicians. Over is an era when the physician's goal is to restore the health and wellbeing of the patient or, if he cannot achieve this, to withhold or withdraw life-sustaining therapies and provide adequate analgesia, care, and company to relieve the suffering and
Confidentiality and Electronic Medical Records
Authors: John Roberts
Journal: Annals of Internal Medicine (1998)

Letters15 March 1998Confidentiality and Electronic Medical RecordsJohn Roberts, MT, Sheila R. Decter, MA, and Denise Nagel, MDJohn Roberts, MTAmerican Civil Liberties Union of Massachusetts; Boston, MA 02111American Jewish Congress, New England Region; Boston, MA 02210National Coalition for Patient Rights; Lexington, MA 02173Search for more papers by this author, Sheila R. Decter, MAAmerican Civil Liberties Union of Massachusetts; Boston, MA 02111American Jewish Congress, New England Region; Boston, MA 02210National Coalition for Patient Rights; Lexington, MA 02173Search for more papers by this author, and Denise Nagel, MDAmerican Civil Liberties Union of Massachusetts; Boston, MA 02111American Jewish Congress, New England Region; Boston, MA 02210National Coalition for Patient Rights; Lexington, MA 02173Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We write in response to Rind and colleagues' article on maintaining the confidentiality of electronic medical records shared over the Internet [1]. Although the proposed policy has some excellent features, we believe it also contains the following flaws.First, no explicit procedure is provided for informing all patients that they may object to the electronic transmission of their records between institutions. Second, it is not clear how clinicians will obtain information about the existence of a patient's records at other institutions and whether this will be done in a way that does not violate patient confidentiality. Third, ...References1. Rind DM, Kohane IS, Szolovits P, Safran C, Chueh HC, Barnett GO. Maintaining the confidentiality of medical records shared over the Internet and the World Wide Web. Ann Intern Med. 1997; 127:138-41. Google Scholar Author, Article, and Disclosure InformationAuthors: John Roberts, MT; Sheila R. Decter, MA; Denise Nagel, MDAffiliations: American Civil Liberties Union of Massachusetts; Boston, MA 02111American Jewish Congress, New England Region; Boston, MA 02210National Coalition for Patient Rights; Lexington, MA 02173 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRe-presenting Reality, Recovering the Social: The Poetics and Politics of Social Realism and Visual Art 15 March 1998Volume 128, Issue 6Page: 510KeywordsElectrode recordingElectronic medical recordsHealth careInternet ePublished: 15 August 2000 Issue Published: 15 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Particulars of a Lawsuit.
Authors: J. B. Murphy
Journal: JAMA (1902)

Chicago, Dec. 11, 1902. <h3>To the Editor:</h3> —Referring to the notice inThe Journal, December 6, concerning suit brought against me for damages, allow me to state the facts: During an operation by Dr. Lemke in the year 1898 his patient had a cerebral embolism, followed by a partial hemiplegia. Shortly after that a lawsuit was commenced against Dr. Lemke, and I was included in the suit, on account of the supposed financial relations between Dr. Lemke and myself. I was not present at the time Dr. Lemke operated, and had nothing to do with the case. The case was tried two weeks ago, and when the plaintiff had completed his evidence, and without the presentation of witnesses and without a defense on the part of Dr. Lemke or myself, the judge instructed the jury to return a verdict in favor of the defendants, thus exonerating Dr. Lemke from any