The Diagnosis of Common Hereditary Hemorrhagic Diseases
Authors: ARMAND J. QUICK
Journal: Annals of Internal Medicine (1961)

Article1 August 1961The Diagnosis of Common Hereditary Hemorrhagic DiseasesARMAND J. QUICK, M.D.ARMAND J. QUICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-2-201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe logical clinical approach to diagnosis is history, physical examination, and laboratory studies, in the order given. For didactic purposes, however, it is advantageous to begin the discussion of the diagnosis of the hereditary hemorrhagic diseases with a consideration of laboratory studies because all known congenital bleeding diseases, with the exception of telangiectasia, appear to have a defect in the clotting mechanism which can be detected by laboratory tests. The first requisite, therefore, for the diagnosis of this group of diseases is an understanding of the principal reactions involved in the clotting process.THE COAGULATION MECHANISMA clotting scheme has...References1. QUICK AJ: Influence of erythrocytes on the coagulation of blood. Amer. J. Med. Sci. 239: 51, 1960. CrossrefMedlineGoogle Scholar2. QUICKEPSTEIN AJE: Thromboplastic activity in human blood. J. App. Physiol. 4: 840, 1952. CrossrefMedlineGoogle Scholar3. QUICKHUSSEYEPSTEIN AJCVE: Activation of thromboplastinogen by thrombin. Amer. J. Physiol. 174: 123, 1953. CrossrefMedlineGoogle Scholar4. QUICK AJ: 'Erythrocytin' and 'erythrochelatin.' Nature 179: 54, 1957. CrossrefMedlineGoogle Scholar5. QUICK AJ: The hereditary haemorrhagic diseases: their classification and diagnosis. Brit. Med. J. 1: 1059, 1959. CrossrefMedlineGoogle Scholar6. QUICK AJ: Hemolysate prothrombin consumption time: a new test for thromboplastinogenic coagulation defects. J. Lab. Clin. Med. 57: 290, 1961. MedlineGoogle Scholar7. BIGGSDOUGLAS RAS: The thromboplastin generation test. J. Clin. Path. 6: 23, 1953. CrossrefMedlineGoogle Scholar8. IZARNHUSSEYQUICK PCVAJ: Comparative thromboplastin activity of acetone-de-hydrated rabbit and human brain. Proc. Soc. Exp. Biol. Med. 91: 193, 1956. CrossrefMedlineGoogle Scholar9. Unpublished data. Google Scholar10. QUICKHUSSEY AJCV: Hyperheparinemia: report of a case. Amer. J. Med. Sci. 234: 251, 1957. MedlineGoogle Scholar11. QUICK AJ: Hemorrhagic Diseases, Lea & Febiger, Philadelphia, 1957. Google Scholar12. QUICKHONORATOSTEFANINI AJRCM: The value and limitations of the coagulation time in the study of the hemorrhagic diseases. Blood 3: 1120, 1948. CrossrefMedlineGoogle Scholar13. QUICKHUSSEY AJCV: Hemophilia B (PTC deficiency or Christmas disease). Arch. Intern. Med. 103: 762, 1959. CrossrefGoogle Scholar14. VON WILLEBRAND EA: Über hereditare Pseudohämophilie. Acta Med. Scand. 76: 521, 1931. CrossrefGoogle Scholar15. QUICK AJ: Sporadic hemophilia. Arch. Intern. Med. 106: 335, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARMAND J. QUICK, M.D.Affiliations: Milwaukee, WisconsinReceived for publication May 5, 1961.Presented as The John Phillips Memorial Award Lecture at the Forty-second Annual Session of The American College of Physicians, Bal Harbour, Florida, May 11, 1961.This work was supported by a grant from the National Heart Institute, National Institutes of Health, U. S. Public Health Service.Requests for reprints should be addressed to Armand J. Quick, M.D., Dept. of Biochemistry, Marquette University School of Medicine, 561 N. 15th St., Milwaukee 3, Wis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe effects of induced cold torpor and time of year on blood coagulation in Pseudemys scripta elegans and Chrysemys picta belliStandardisierung des Quick-Testes Referenz-Thromboplastin oder Referenz-PlasmenA Clinical Evaluation of Plasma Thromboplastin Antecedent (PTA) DeficiencyFRED G. CONRAD, WILLIAM L. BRENEMAN, DOROTHY B. GRISHAM, B.S.Die hämorrhagischen DiathesenTHE INTERPRETATION OF HEMOSTATIC TESTS IN UNEXPLAINED BLEEDING*THEORETICAL CONSIDERATIONS IN ANALYSIS OF PSYCHOPHYSIOLOGICAL DATA*Anticoagulant Action of Adenosine TriphosphateSimultaneous hypoprothrombinemia, indirect hyperbilirubinemia, and diabetes mellitusMedical genetics 1961 1 August 1961Volume 55, Issue 2Page: 201-209KeywordsBlood plasmaGenetic diseasesHeartHemophilia AHemorrhageLaboratory testsMedical servicesPrevention, policy, and public healthResearch laboratories ePublished: 1 December 2008 Issue Published: 1 August 1961 PDF downloadLoading ...