tbuckley/cabot-search huggingface dataset:
Novel Molecular Approach for Detecting the Changes in Mice Heart After Rolipram Treatment via FTIR Spectroscopy
Authors: Ipek Komsuoglu, Sevgi Turker, Umut Celikyurt, Oguz Mutlu, Esen Gumuslu, Furuzan Yıldız Akar, Dilek Ural
Journal: Journal of the American College of Cardiology (2013)
C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia
Authors: Rick Kapur, Katja M. J. Heitink-Pollé, Leendert Porcelijn, Arthur E. H. Bentlage, Marrie C. A. Bruin, Remco Visser, Dirk Roos, Richard B. M. Schasfoort, Masja de Haas, C. Ellen van der Schoot, Gestur Vidarsson
Journal: Blood (2014)
Chronic Stable Angina
Authors: Jonathan Abrams
Journal: New England Journal of Medicine (2005)

A 47-year-old man reports a six-month history of intermittent chest discomfort while playing squash. He describes lower substernal tightness with numbness of the left upper arm only during exertion. He does not smoke. His father died suddenly at the age of 49 years. His blood pressure is 138/84 mm Hg. The level of total cholesterol is 261 mg per deciliter, low-density lipoprotein cholesterol 172 mg per deciliter, and high-density lipoprotein cholesterol 50 mg per deciliter, and the triglyceride level is 113 mg per deciliter. An exercise test is positive, with pain and 1.5 mm of horizontal ST-segment depression at stage 4 of the Bruce protocol. How should the patient's case be managed?
Control of Glucose Level-Reply
Authors: Stephen B. Lewis
Journal: JAMA (1981)

<h3>In Reply.—</h3> Although patients 1 and 2 became mildly and briefly hypoglycemic (nadir of serum glucose, 54 and 48 mg/dL, respectively), we readily detected, corrected, and modified our protocol to avoid this problem in the next six patients. Infusion of insulin requires careful blood glucose monitoring as we stressed in our article. Patient 3 was severely hyperglycemic before surgery (264 mg/dL). Furthermore, it is well known that surgical and anesthetic stress may elevate serum glucose, a phenomenon avoided in patient 3 by insulin infusion. Finally, we warn those who seek normoglycemia perioperatively to be alert to the need for higher insulin infusion than recommended in our article for the diabetic who has infection or who is receiving high-dose corticosteroids or other forms of stress adding to that of general anesthesia and surgery.
Inhibition of marrow CFU-E colony formation from human immunodeficiency virus-infected patients by β- and γ-interferon
Authors: Gail Dallalio, Melissa North, Robert T. Means
Journal: American Journal of Hematology (1996)

Increased production of cytokines such as β-interferon (IFN) and γ-IFN may contribute to the anemia frequently observed in patients with human immunodeficiency virus (HIV) infection. The hypothesis that HIV infection might enhance the susceptibility of erythroid progenitors to cytokine-mediated inhibition was evaluated by comparing the effects of β- and γ-IFN on in vitro colony formation by marrow erythroid colony-forming units (CFU-E) from HIV patients, normal volunteers, and anemic non-HIV-infected individuals. CFU-E colony formation from HIV patients was not significantly different from controls, and the degree of inhibition by IFN did not differ among patient subsets. HIV infection does not appear to impair baseline CFU-E colony formation, nor does it appear to enhance the susceptibility of CFU-E to suppression by cytokines. © 1996 Wiley-Liss, Inc.
Identification of viable myocardium by echocardiography during dobutamine infusion in patients with myocardial infarction after thrombolytic therapy: Comparison with positron emission tomography
Authors: Luc A. Piérard, Christian M. De Landsheere, Christian Berthe, Pierre Rigo, Henri E. Kulbertus
Journal: Journal of the American College of Cardiology (1990)
Hypertrophic Obstructive Cardiomyopathy in an Infant — Propranolol Therapy for Three Years
Authors: David G. Shand, C. Gordon Sell, John A. Oates
Journal: New England Journal of Medicine (1971)

ALTHOUGH the beta-adrenergic blocking drug, propranolol, has been used in adults with hypertrophic obstructive cardiomyopathy,1 2 3 its use in children has not yet been reported. The youngest child in whom the diagnosis has been confirmed was one year of age,4 and operative correction was unsuccessful. The eight-week-old child described below had a three-year follow-up of propranolol treatment. Because there was no information on pediatric dosage, therapy was monitored by measurements of plasma levels of the drug.Case ReportThis infant with no relevant past or family history was delivered normally at full-term weighing 3.7 kg. She failed to thrive and weighed . . .
The Importance of Methicillin-Resistant Staphylococcus aureus.
Authors: E. Jack Benner
Journal: Annals of Internal Medicine (1969)

s1 May 1969The Importance of Methicillin-Resistant Staphylococcus aureus.E. Jack Benner, M.D., F.A.C.P., F. H. Kayser, M.D.E. Jack Benner, M.D., F.A.C.P.Search for more papers by this author, F. H. Kayser, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1089_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSizable outbreaks of infections caused by methicillin-resistantStaphylococcus aureushave occurred in Europe, England, and now the United States. The clinical significance, epidemiological factors, and antimicrobic susceptibility of these unusual staphylococci have been defined by analysis of 139 isolates containing these organisms. The kinds of infections occurring were those to be expected in nosocomial problems. Patients afflicted with chronic debilitating diseases were the usual victims. At least 50% of the infections were not acquired until at least 21 days of hospitalization, and all were contracted in a hosiptal setting. Infections were a common cause of death; 18 of 29 patients... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Davis, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByANTIBIOTIC COMBINATIONSInfectious diseases: annual review of significant publications. 1 May 1969Volume 70, Issue 5Page: 1089-1089KeywordsFactor analysisHospitalizationsMethicillin-resistant Staphylococcus aureusNosocomial infectionsStaphylococcal infection Issue Published: 1 May 1969 PDF DownloadLoading ...
Carotid artery intima-media thickness and lipid profile in adults with growth hormone deficiency after long-term growth hormone replacement
Authors: Débora Vieira Soares, Luciana Diniz Carneiro Spina, Rosane Resende de Lima Oliveira Brasil, Eliane Maria Carvalho da Silva, Priscila Marise Lobo, Elizabeth Salles, Claúdia Medina Coeli, Flávia Lúcia Conceição, Mario Vaisman
Journal: Metabolism (2005)
Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta‐analysis
Authors: C. Anandan, U. Nurmatov, A. Sheikh
Journal: Allergy (2009)

There is conflicting evidence on the use of omega 3 and omega 6 supplementation for the prevention of allergic diseases. We conducted a systematic review evaluating the effectiveness of omega 3 and 6 oils for the primary prevention of sensitization and development of allergic disorders.We searched The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, LILACS, PsycInfo, AMED, ISI Web of Science and Google Scholar for double-blind randomized controlled trials. Two authors independently assessed articles for inclusion. Meta-analyses were undertaken using fixed effects modelling, or random effects modelling in the event of detecting significant heterogeneity.Of the 3129 articles identified, 10 reports (representing six unique studies) satisfied the inclusion criteria. Four studies compared omega 3 supplements with placebo and two studies compared omega 6 supplements with placebo. There was no clear evidence of benefit in relation to reduced risk of allergic sensitization or a favourable immunological profile. Meta-analyses failed to identify any consistent or clear benefits associated with use of omega 3 [atopic eczema: RR = 1.10 (95% CI 0.78-1.54); asthma: RR = 0.81 (95% CI 0.53-1.25); allergic rhinitis: RR = 0.80 (95% CI 0.34-1.89) or food allergy RR = 0.51 (95% CI 0.10-2.55)] or omega 6 oils [atopic eczema: RR = 0.80 (95% CI 0.56-1.16)] for the prevention of clinical disease.Contrary to the evidence from basic science and epidemiological studies, our systematic review and meta-analysis suggests that supplementation with omega 3 and omega 6 oils is probably unlikely to play an important role as a strategy for the primary prevention of sensitization or allergic disease.
THE SYNTAX SCORE AND THE PRESENCE OF TOTAL OCCLUSION LESIONS AS PREDICTOR OF MORTALITY IN PATIENTS WITH ACUTE CORONARY SYNDROME COMPLICATED BY CARDIOGENIC SHOCK
Authors: Hidenori Adachi, Yoshinori Yasuoka, Yuhei Nojima, Kiyoshi Kume, Susumu Hattori, Yoshiki Noda, Ryo Matsutera, Yasuaki Kohama, Motohiro Kosugi, Takuro Yoshio, Masashi Yamato, Tatusya Sasaki
Journal: Journal of the American College of Cardiology (2014)
Strategies utilized by migrating neurons of the postnatal vertebrate forebrain
Authors: Steven A Goldman, Marla B Luskin
Journal: Trends in Neurosciences (1998)

<h2>Abstract</h2> Structural brain repair has become a possibility with the identification and characterization of persistent neuronal progenitor cells in both the neonatal and adult brain. However, despite recent advances in the identification, propagation and expansion of these cells, they will not be useful therapeutically until methods are available for directing or delivering them to sites of need. As a result, the natural history and induction of neuronal migration into adult brain tissue has assumed new importance in clinical neurobiology. In this review we consider the cellular and molecular bases of neuronal migration into the postnatal forebrain. In particular, we discuss two natural paradigms of postnatal neuronal recruitment: radial-cell-directed neuronal migration to the songbird neostriatum, and neurophilic migration to the rodent olfactory bulb. In each, we will focus on the dynamic interactions between the migrants, their cellular guides and the local environment, and the effect of those interactions on migrational success.
Prenatal chromosomal diagnosis. Racial and geographic variation for older women in Georgia
Authors: D. C. Sokal
Journal: JAMA (1980)

In a study of Georgia women aged 40 years and older, 15% made use of prenatal chromosomal diagnosis. There was, however, substantial racial and geographic variation, ranging from a use ratio of 60% among whites in two large urban counties to 0.5% among blacks outside Augusta and Atlanta health districts. This simple population-based epidemiologic analysis suggests that future program planning for genetic services in Georgia should address ways to increase access by rural women, especially blacks. Similar analyses in other states could be used for planning genetic services. (<i>JAMA</i>244:1355-1357, 1980)
Growth Changes in Children and Adolescents With Short-Term Diabetes
Authors: Emilio Bognetti, Maria Cristina Riva, Riccardo Bonfanti, Franco Meschi, Matteo Viscardi, Giuseppe Chiumello
Journal: Diabetes Care (1998)

OBJECTIVE Height and weight changes during the first 3 years of diabetes were prospectively followed in 152 diabetic children and adolescents. RESEARCH DESIGN AND METHODS The study sample consisted of 152 Caucasian diabetic patients (84 boys; 68 girls) followed from diabetes onset in the Paediatric Diabetes Unit and 80 Caucasian normal subjects (49 boys; 31 girls) assessed in the Outpatient General Paediatric Clinic of the same hospital for routine examination and not affected by problems that might influence growth. Diabetic patients and control subjects were consecutively enrolled in the study between 1989 and 1992; diabetic patients with positive markers for celiac disease (positive antiendomysial antibodies) and thyroid disease (positive antimicrosomial antibodies) or any other chronic disease were not considered in the study. Mean age of diabetic patients (8.9 ± 4.1 years) and control subjects (8.5 ± 4.2 years) at recruitment in the study was similar. RESULTS At onset of diabetes, the mean height expressed as the height standard deviation score (HSDS) was significantly greater than the expected values (P &amp;lt; 0.0001) and was independent of sex and pubertal stage. During the first 3 years of diabetes, HSDS decreased significantly (F = 6.9; P &amp;lt; 0.001). Meanwhile, growth velocity as standard deviation score (SDS) decreased significantly between the 1st and 2nd year (−0.12 ± 2.1; −0.76 ± 2.6, respectively; P &amp;lt; 0.05), but it was similar between the 2nd and 3rd year of diabetes. Weight expressed as SDS increased significantly during the first 2 years of diabetes but not thereafter. Height changes during the study period were independent from pubertal stage and sex. Metabolic control and insulin requirement, in our series, were not clearly related to height and weight changes. CONCLUSIONS Diabetic patients at onset of diabetes are taller than age- and sex-matched nondiabetic subjects. During the first years of the disease, linear growth decreases independently of metabolic control and weight changes.
Tumor Necrosis Factor–α rs361525 Polymorphism Is Associated with Increased Local Production and Downstream Inflammation in Chronic Obstructive Pulmonary Disease
Authors: Elizabeth Sapey, Alice M. Wood, Ali Ahmad, Robert A. Stockley
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: Chronic obstructive pulmonary disease (COPD) has a genetic component, explaining susceptibility. Tumor necrosis factor (TNF)-α polymorphisms have been associated with COPD, but it is unclear if genotype influences clinical phenotype, protein expression, and bioactivity.Objectives: To determine if a functional polymorphism was important by assessing TNF-α expression and activity and its association with clinical severity over time.Methods: Patients with COPD with rs361525 polymorphism were matched to patients with COPD without rs361525 polymorphism. TNF-α, its antagonists, and downstream mediators were measured in plasma and sputum. To determine TNF-α bioactivity, IL-8 secretion from primary bronchial epithelial cells (PBECs) was measured, and neutrophil migration was assessed using sputum from both subject groups in the presence and absence of TNF-α antibody. Subjects were followed annually and compared.Measurements and Main Results: Patients with polymorphism had more chronic bronchitis, a lower body mass index, and a greater annual decline in FEV1 than patients with COPD without rs361525 polymorphism. TNF-α concentrations were 100-fold higher in airway secretions from the patients with the rs361525 polymorphism, with no difference in TNF-α antagonists. Their lung secretions contained more IL-8 and myeloperoxidase, consistent with downstream inflammation. Sputum from patients with rs361525 polymorphism induced greater secretion of IL-8 from PBECs and increased neutrophil migration. These effects could be abrogated by TNF-α antibody, demonstrating the bioactivity of TNF-α in lung secretions from this group.Conclusions: This TNF-α polymorphism is associated with clinical features of disease including progression. There is clear evidence of TNF-α overexpression and bioactivity with neutrophilic inflammation. The polymorphism is likely to be a factor that influences a COPD disease phenotype and its progression.
Points from Letters: Drug Traffic
Authors: F. M. Owers
Journal: BMJ (1967)

example-English doctors.Surely the sen- sible thing for the Government of Pakistan would be to encourage these doctors to return to Pakistan, and if necessary " exploit" the services of their wives.England may suffer by losing these qualified people, but surely Pakistan's need of their services is even greater.The B.M.A. has played a great part in medical history, and surely its sister associa- tion, with Professor Hamid Ali Khan in the chair, could follow its example in this way and attempt the abolition of the reverse "'colour bar."I hope many of my fellow- countrymen will pluck up courage to fight this absurd undemocratic law and injustice.I also must remain anonymous.-Iam, etc., ANON.
Normal haematological values: sex difference in neutrophil count.
Authors: B J Bain, J M England
Journal: BMJ (1975)

Blood counts were performed on 100 male and 100 female staff to establish normal ranges for our hospital. Neutrophil counts were found to be on average 0.66 times 10-9/1 (660/mm-3) higher in women than in men. Statistically this difference was highly significant and was not due to the fact that many of the women were taking oral contraceptives. The neutrophil counts of the men and women were also on average 0.50 times 10-9/1 (500/mm-3) greater in the afternoon than in the morning. A correlation was observed between the neutrpphil and the monocyte counts.
Effect of on-line conductivity plasma ultrafiltrate kinetic modeling on cardiovascular stability of hemodialysis patients
Authors: F Locatelli, S Andrulli, S Di Filippo, B Redaelli, S Mangano, C Navino, R Ariano, M Tagliaferri, T Fidelio, M Corti, S Civardi, C Tetta
Journal: Kidney International (1998)
Respiratory Cancer and Inhaled Inorganic Arsenic in Copper Smelters Workers: A Linear Relationship with Cumulative Exposure that Increases with Concentration
Authors: Jay H. Lubin, Lee E. Moore, Joseph F. Fraumeni, Kenneth P. Cantor
Journal: Environmental Health Perspectives (2008)

Inhalation of high levels of airborne inorganic arsenic is a recognized cause of respiratory cancer. Although multiple epidemiologic studies have demonstrated this association, there have been few analyses of the mathematical relationship between cumulative arsenic exposure and risk of respiratory cancer, and no assessment as to whether and how arsenic concentration may modify this association.
Natural Killer Cell–mediated Lysis of Autologous Cells Modified by Gene Therapy
Authors: Concetta Liberatore, Marusca Capanni, Nicola Albi, Isabella Volpi, Elena Urbani, Loredana Ruggeri, Amedea Mencarelli, Francesco Grignani, Andrea Velardi
Journal: The Journal of Experimental Medicine (1999)

This study investigated the role of natural killer (NK) cells as effectors of an immune response against autologous cells modified by gene therapy. T lymphocytes were transduced with LXSN, a retroviral vector adopted for human gene therapy that carries the selectable marker gene neo, and the autologous NK response was evaluated. We found that (i) infection with LXSN makes cells susceptible to autologous NK cell-mediated lysis; (ii) expression of the neo gene is responsible for conferring susceptibility to lysis; (iii) lysis of neo-expressing cells is clonally distributed and mediated only by NK clones that exhibit human histocompatibility leukocyte antigen (HLA)-Bw4 specificity and bear KIR3DL1, a Bw4-specific NK inhibitory receptor; and (iv) the targets are cells from HLA-Bw4(+) individuals. Finally, neo peptides anchoring to the Bw4 allele HLA-B27 interfered with KIR3DL1-mediated recognition of HLA-B27, i.e., they triggered NK lysis. Moreover, neo gene mutations preventing translation of two of the four potentially nonprotective peptides reduced KIR3DL1(+) NK clone-mediated autologous lysis. Thus, individuals expressing Bw4 alleles possess an NK repertoire with the potential to eliminate autologous cells modified by gene therapy. By demonstrating that NK cells can selectively detect the expression of heterologous genes, these observations provide a general model of the NK cell-mediated control of viral infections.
Diffuse peritonitis and chronic ascites due to infection with Chlamydia trachomatis in patients without liver disease: new presentation of the Fitz-Hugh-Curtis syndrome.
Authors: U A Marbet, G A Stalder, J Vogtlin, J Loosli, A Frei, B Althaus, K Gyr
Journal: BMJ (1986)

Two women were admitted for increasing abdominal pain, vaginal discharge, and severe or moderate chronic ascites. Diffuse peritonitis without evidence of liver disease was found in both cases, and in one the ascites and vaginal discharge contained Chlamydia trachomatis. Both patients responded to doxycycline, and this and the laboratory findings pointed strongly to C trachomatis as the aetiological agent. C trachomatis may cause severe peritoneal infections with chronic ascites formation in the absence of liver disease in women with the Fitz-Hugh-Curtis syndrome. Prompt diagnosis and antibiotics lead to rapid cure.
Infant Death Rates
Authors: Bruce E. Balfe
Journal: JAMA (1971)

To  Editor.—  I agree wholeheartedly with Phillips' point that  differences in infant death rates between  United States and various European nations cannot be attributed to differences in statistical reporting and technique. Indeed, one of my major purposes in writing  editorial was to silence those who repeatedly suggest that the United States is really number one if  truth were known.  I am familiar with Moriyama's work, and I am also aware of various efforts to develop an index of health which will hopefully provide a more comprehensive measure of health status than  infant death rate. Such an index will include infant death as one of many factors which should be monitored in evaluating  health of a population. The editorial was written to encourage this type of effort and discourage those who believe, despite empirical evidence to  contrary, that  United States health system
Permanent Plastic-Embedded Minifilms
Authors: Robert B. Stonehill
Journal: JAMA (1962)

IN THE EVALUATION of patients with abnormal chest roentgenograms, comparison with previous x-ray films is always desirable. When the abnormalities are suggestive of neoplasm or active granulomatous infections, procurement of previous films assumes paramount diagnostic importance. In addition, the less striking abnormalities of the lung, thorax, mediastinum, cardiac silhouette, and pleura can be more accurately interpreted when previous studies are available. The procurement of earlier roentgenograms is frequently a vexing, time-consuming problem. This is true especially in a migrating population, such as the armed forces personnel and their dependents. The same difficulty is encountered in civilian medical practice, but less often. Delays in diagnosis and therapy frequently result while attempts are made to procure the earlier films. The anxiety of the patient also increases during the waiting period. Occasionally, the patient is submitted to surgical, diagnostic procedures which could have been avoided if previous x-ray films had been available. Therefore,
30 ACUTE LIVER FAILURE: CURRENT EUROPEAN PERSPECTIVE
Authors: J. Wendon, M. Manns, G. Alexander, M. Aldersley, A. Burroughs, K. Simpson, D. Mutimer, F. Nevens, W. Bernal, P.-F. Laterre, Y. Ilan, M. Hudson, F. Stolze-Larsen, F. Saliba, V. Arroyo, N. Murphy, G. Lalazar, J. O'Bierne, J. Hadem, D. Samuel
Journal: Journal of Hepatology (2010)