Mechanisms of the Crystal Deposition Diseases-Gout and Pseudogout
Authors: DANIEL J. MCCARTY
Journal: Annals of Internal Medicine (1973)

Editorial1 May 1973Mechanisms of the Crystal Deposition Diseases-Gout and PseudogoutDANIEL J. MCCARTY JR., M.D.DANIEL J. MCCARTY JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-767 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMonosodium urate crystal-deposition disease (gout) is the clinician's friend, for it can be diagnosed with precision and treated with specificity. For goutisthese urate crystals, whether they are interacting with phagocytes in the acute episode or hardening into concretions in the nearly avascular structures in and about joints. The crystals are invariably present in gout regardless of the cause of the antecedent hyperuricemia and may be identified rapidly by using polarized light microscopy ( 1 ). In a bridge game one peek is worth two finesses; in the differential diagnosis of arthritis one peek through the polarizing microscope is...References1. MCCARTYHOLLANDER DJ: Identification of urate crystals in gouty synovial fluid. Ann Intern Med 54:452-460, 1961 LinkGoogle Scholar2. MCCARTY D: Pseudogout; articular Chondrocalcinosis. Calcium pyrophosphate crystal deposition disease, in Arthritis and Allied Conditions, 8th ed., edited by HOLLANDER JL, MCCARTY DJ. Philadelphia, Lea & Febiger, 1972, pp. 1140-1160 Google Scholar3. MCCARTY D: Phagocytosis of urate crystals in gouty synovial fluid. Am J Med Sci 243:288-295, 1962 CrossrefGoogle Scholar4. MCCARTYKOHNFAIRES DNJ: The significance of calcium phosphate crystals in the synovial fluid of arthritic patients: the "pseudogout syndrome." I. Clinical aspects. Ann Intern Med 56:711-737, 1962 LinkGoogle Scholar5. BLUHMRIDDLEBARNHART GJM: Ultrathin study of exudative leukocytes provoked by acticular urate crystals (abstract). Arthritis Rheum 12:657-658, 1969 Google Scholar6. SCHUMACHERPHELPS HP: Sequential changes in human polymorphonuclear leukocytes after urate crystal phagocytosis. An electron microscopic study. Arthritis Rheum 14:513-526, 1971 CrossrefMedlineGoogle Scholar7. SCHUMACHER H: Phagocytosis of calcium pyrophosphate crystals by polymorphonuclear leukocytes: sequential electron microscopic observations (abstract). Arthritis Rheum 15:453, 1972 Google Scholar8. SCHUMACHER H: The synovitis of pseudogout: electron microscopic observations. Arthritis Rheum 11:426-435, 1968 CrossrefMedlineGoogle Scholar9. MCCARTY D: Urate crystal phagocytosis by polymorphonuclear leukocytes and the effects of colchicine, in Phagocytic Mechanisms in Health and Disease, edited by WILLIAMS RC, FUDENBERG HH. New York, International Medical Book Corp., 1972, pp. 107-121 Google Scholar10. WALLINGFORDMCCARTY WD: Differential membranolytic effects of microcrystalline sodium urate and calcium pyrophosphate dihydrate. J Exp Med 133:100-112, 1971 CrossrefMedlineGoogle Scholar11. WALLINGFORDTREND WB: Phagolysosome rupture after monosodium urate (MSU) but not calcium pyrophosphate dihydrate (CPPD) phagocytosis in vitro (abstract). Arthritis Rheum 14:420-421, 1971 Google Scholar12. WEISSMANNZURIERSPIELER GRP: Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. J Exp Med 134 (no. 3, part 2):149s-165s, 1971 CrossrefMedlineGoogle Scholar13. ANDREWSPHELPS RP: Release of lysosomal enzymes from polymorphonuclear leukocytes (PMN) after phagocytosis of monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals: effect of colchicine and indomethacin (abstract). Arthritis Rheum 14:368, 1971 Google Scholar14. WEISSMANNRITA GG: Molecular basis of gouty inflammation: interaction of monosodium urate crystals with lysosomes and liposomes. Nature [New Biol] (Lond) 240:167-172, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. 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Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Chicago Pritzker School of Medicine Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByWhy Does Hyperuricemia Not Necessarily Induce Gout?GoutPositive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flaresArticular Pathology of Gout, Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate Crystal Deposition ArthropathiesCrystal-Associated ArthropathiesSequential Study of Pleural Peritoneal and Blood Cells in Acute Pleurisy Induced by Calcium Pyrophosphate in the RatEarly changes in immune parameters induced by an acute nonantigenic inflammation in mouse: Influence of imuthiol2′5′-oligoadenylate synthetase activity level: An interferon-induced enzyme in macrophages derived from normal or inflamed miceIn vivo effects of an acute nonimmunological inflammation in rats on the lymphoproliferative response to mitogensAcute non-specific inflammation and modification of macrophage and lymphocyte funtionsThe effect of inorganic pyrophosphate (PPi) anions on the in vitro collagen fibril formationHeberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.Initial Events in the Development of an Acute Attack of Gouty ArthritisPathogenesis of Crystal-Induced SynovitisRheumatology: An Annotated Bibliography of Recent Literature References to Journal Articles and Other PapersRHEUMATOLOGY COMMITTEE, MEDICAL-KNOWLEDGE SELF-ASSESSMENT PROGRAM IV, AMERICAN COLLEGE OF PHYSICIANSRoentgenographic aspects of calcium pyrophosphate dihydrate crystal deposition disease (pseudogout)Pathogenese der Harnsäureablagerungen und des GichtanfallesLOCAL CONCENTRATION OF URATE IN THE PATHOGENESIS OF GOUT 1 May 1973Volume 78, Issue 5Page: 767-771KeywordsArthritisGamesGoutLight microscopyPhagocytesSpecificityUric acid Issue Published: 1 May 1973 PDF DownloadLoading ...