tbuckley/cabot-search huggingface dataset:
Basic calcium phosphate crystals induce synthesis and secretion of 92 kDa gelatinase (gelatinase B/matrix metalloprotease 9) in human fibroblasts
Authors: G. M McCarthy, A. M Macius, P. A Christopherson, L. M Ryan, T. Pourmotabbed
Journal: Annals of the Rheumatic Diseases (1998)

OBJECTIVE Synovial fluid basic calcium phosphate (BCP) crystals are associated with severe joint degeneration accompanied by synovial hypertrophy. The metalloprotease 92 kDa gelatinase (MMP-9) has been implicated in the degradation of extracellular matrix in osteoarthritis, but the ability of BCP crystals to induce gelatinase in human fibroblasts or in adult porcine chondrocytes has not previously been studied. The hypothesis that the mitogenic response to BCP crystals is accompanied by induction and secretion of MMP-9 was studied. METHODS MMP-9 messenger RNA (mRNA) was detected by northern blot and reverse transcription-polymerase chain reaction (RT-PCR). Gelatinase secretion was identified by western blot and zymography of conditioned media. RESULTS BCP crystals caused a concentration dependent induction of MMP-9 mRNA accumulation and protein secretion in human fibroblasts but not in adult porcine chondrocytes. CONCLUSION BCP crystals induce MMP-9 production by HF but not adult porcine chondrocytes. Fibroblast MMP-9 may be an important mediator of the joint destruction associated with synovial fluid BCP crystals.
Adherence of Glucan-Positive and Glucan-Negative Streptococcal Strains to Normal and Damaged Heart Valves
Authors: Carlos H. Ramirez-Ronda
Journal: Journal of Clinical Investigation (1978)

The adherence of 18 strains of streptococci to sections of normal canine and human aortic, mitral, and tricuspid valves and to canine interatrial septum was compared in an in vitro system. Quantitative measurements of adherence ratios were performed by two independent methods. Adherence ratios for Streptococcus mutans, S. sanguis, S. bovis, and Group D streptococci were higher (0.0058-0.0101) than for the other streptococcal strains studied (0.0025-0.0041). With the exception of Group D streptococci, adherence ratios for each bacterial strain were similar with the aortic, mitral, and tricuspid valve sections. Adherence ratios with normal human and canine valve leaflets were similar, but adherence ratios with interatrial septum were lower than with normal valve sections.
Clinical Features of 52 Neonates with Hyperinsulinism
Authors: Pascale de Lonlay-Debeney, Florence Poggi-Travert, Jean-Christophe Fournet, Christine Sempoux, Carlo Dionisi Vici, Francis Brunelle, Guy Touati, Jacques Rahier, Claudine Junien, Claire Nihoul-Fékété, Jean-Jacques Robert, Jean-Marie Saudubray
Journal: New England Journal of Medicine (1999)

Neonatal hyperinsulinemic hypoglycemia is often resistant to medical therapy and is often treated with near-total pancreatectomy. However, the pancreatic lesions may be focal and treatable by partial pancreatic resection.
Welsh heart surgeons demand expansion in services
Authors: R. Dobson
Journal: BMJ (1999)

Clinicians in Wales have claimed that the number of heart operations carried out in the principality needs to double. Wales has more than 800 people on waiting lists and a 20% higher mortality from heart disease than England, so for a population of 2.5 million the number of operations should be 2400 rather than the existing 1200, said …
Management of Pain Through Cerebral Activation
Authors: Charles D. Kaplan, Michael Wogan
Journal: Psychotherapy and Psychosomatics (1976)

The present experiment was designed to explore the relationship between pain, language and cerebral functioning in normal subjects, as an analogue to alexithymia. Left hemisphere cerebral activation, as measured by an EEG-alpha ratio score, was found to be associated with a reported increase in painful sensation during painful stimulation. Right hemisphere activation was found to be associated with a decrease in reported pain. The results were interpreted in terms of the mobilization of fantasy processes, following experimental instructions, which seem to be mediated by right hemisphere activation. Uninstructed subjects, lacking a stable visualization, utilize a left-hemisphere, verbal mode to cope with the pain. It is suggested that left-hemisphere mobilization, and a lack of right-hemisphere processing of painful stimulation may be in part responsible for the alexithymic patients' psychosomatic symptoms.
Increased Risk of Neuroectodermal Tumors and Stomach Cancer in Relatives of Patients With Ewing's Sarcoma Family of Tumors
Authors: B. Novakovic, A. M. Goldstein, L. H. Wexler, M. A. Tucker
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Increased Risk of Neuroectodermal Tumors and Stomach Cancer in Relatives of Patients With Ewing's Sarcoma Family of Tumors Get access Biljana Novakovic, Biljana Novakovic Genetic Epidemiology Branch, National Cancer InstituteBethesda, Md Correspondence to: Biljana Novakovic, M.D., National Cancer Institute. EPN, Rm. 400, 6130 Executive Blvd., Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar Alisa M. Goldstein, Alisa M. Goldstein Genetic Epidemiology Branch, National Cancer InstituteBethesda, Md Search for other works by this author on: Oxford Academic PubMed Google Scholar Leonard H. Wexler, Leonard H. Wexler Pediatric Branch, National Cancer InstituteBethesda, Md Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret A. Tucker Margaret A. Tucker Genetic Epidemiology Branch, National Cancer InstituteBethesda, Md Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 22, 16 November 1994, Pages 1702–1706, https://doi.org/10.1093/jnci/86.22.1702 Published: 16 November 1994 Article history Received: 13 May 1994 Revision received: 23 August 1994 Accepted: 23 August 1994 Published: 16 November 1994
Managing major public health crises
Authors: A. Nicoll, D. Wilson, N. Calvert, P. Borriello
Journal: BMJ (2001)

The recent terrorist attacks in New York have shown how all societies need rescue, health, and public health services to respond immediately to major disasters. Subsequent covert releases of anthrax (and scares and hoaxes) have been straining public health and reference laboratory services.1 The epidemic of foot and mouth disease in the United Kingdom has not directly threatened human health, but its control has required huge efforts and resources. Control measures have affected health services: primary care has had to deal with the stress experienced by affected communities; public health services have responded to disposing of over four million animals with concomitant zoonoses like bovine spongiform encephalopathy, Escherichia coli O157, and the specialist microbiological reference laboratories were needed to exclude cases of human infection.2

What lessons can be learnt from these events? This question is timely in Britain, because the arrangements for health protection in the new NHS are yet to be finalised, though we know that regional directors of public health will oversee this function (see box 1). 3 4

### Box 1 : Components of health protection3

Monitoring of and protection against communicable disease

Protection against non-communicable environmental hazards

Planning for and response to emergencies RETURN TO TEXT

Events in the United States emphasise the need to be able to deliver …
New focus on spinal cord injury
Authors: I. Gunby
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen replacement therapy in breast cancer survivors
Authors: C. D. Atkins
Journal: JAMA (1995)

To the Editor.  —Dr Cobleigh and colleagues 1 state that the 27 studies they analyzed  not consistently demonstrate an increased risk of breast cancer among women who have ever used ERT [estrogen replacement therapy]. However, they fail to recognize that most negative studies do not have sufficient power to rule out clinically significant differences (see confidence intervals in Table 1 of Cobleigh et al). Since the most reliable estimates of association of any factor with a disease are obtained from prospective cohort studies rather than retrospective case-control studies, it is important that a prospective analysis based on the Nurses' Health Study 2 showed a moderate increase in the risk of breast cancer associated with current use of ERT. Bergkvist et al 3 also found an increased risk of breast cancer in their prospective study from Sweden, which, in addition, showed no protection from the addition of progestins.  Cobleigh et
Previous Hospital Care as a Risk Factor for Pneumonia
Authors: David S. Fedson
Journal: JAMA (1982)

In the Oxford Record Linkage Study population in 1970, seven hundred ninety-three persons were hospitalized for or died as a result of pneumonia. Thirty-six percent who survived and 49% who died had been discharged from hospital within the previous five years. For the period 1963 through 1970, cohort analysis determined the probability of subsequent readmission and/or death caused by pneumonia within the next five years for patients discharged with any condition and with high-risk conditions only. From this analysis, it was estimated that pneumococcal immunization of relatively few discharged patients would prevent each subsequent readmission and death from pneumococcal pneumonia. These results suggest that, in addition to age and underlying medical condition, patterns of previous hospital care can be used to identify many persons at increased risk of developing pneumonia. If current patterns of previous hospital care are similar to those found in Oxfordshire, physicians should consider giving pneumococcal vaccine to patients who are discharged from hospitals.
Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34− fraction
Authors: David C. Taussig, Jacques Vargaftig, Farideh Miraki-Moud, Emmanuel Griessinger, Kirsty Sharrock, Tina Luke, Debra Lillington, Heather Oakervee, Jamie Cavenagh, Samir G. Agrawal, T. Andrew Lister, John G. Gribben, Dominique Bonnet
Journal: Blood (2010)
Patient leaflets are worthless
Authors: Des Spence
Journal: BMJ (2012)

In the 1990s our offices were crammed with stuff: plastic joints, stress balls, wall clocks, and broken lamps—nobody was seemingly able to resist pharma’s freebie tat, however useless. I also had a pile of textbooks but most clinical knowledge remained in the head of the local specialist. But the greatest space culprit was the patient leaflets, deemed the “must have” for the empowerment of patients. Filing cabinets were jammed closed with leaflets for everything, spewing across the desks and on to the floor. 

Research suggested that patients retained nothing that they were …
American Medical Schools and the Practice of Medicine: A History
Authors: Richard C. Hermann
Journal: JAMA (1988)

This book presents an intensely quantitative and highly informative history and analysis of American medical schools. In the first half of the book, the author, a sociologist at the University of Maryland, addresses the historical development of medical education from the 18th century to 1950. The second half combines post-1950 developments with a critique of the contemporary medical school. Rothstein supports his assertions with data of most every sort. He cites surveys, studies, and statistics to characterize faculty, students, and practicing physicians of every period. He similarly evaluates hospitals, patients, diseases, and the efficacy of treatments of each era. Observations of historical participants add perspective to the data, as do the author's own summaries and conclusions. The historical half of the book alternates between the subjects of medical care and medical education. It examines the expansion of useful materia medica from the 18th century's evacuants and opium and traces the
Smoking Habits and Coronary Atherosclerotic Heart Disease
Authors: David M. Spain
Journal: JAMA (1961)

In this study of 3,000 males the statistical association of coronary artherosclerotic heart disease (CAHD) and smoking habits was most striking under the age of 51. In this group 21 (11.7%) of 179 heavy cigarette smokers had CAHD, whereas 100 (6.5%) of 1,521 other individuals had CAHD. The ratio of myocardial infarcts to isolated angina pectoris was 1.3:1 in heavy smokers, and 0.5:1 in other categories. Heavy cigarette smoking was also associated with higher serum cholesterol levels. It was suggested not so much as a factor in atherogenesis, but as a factor in precipitating acute clinical events in individuals with advanced CAHD. Cigar, pipe, and light cigarette smoking did not appear to be related to the problem.
Ghazal for Global Health
Authors: Ali M. Tahvildari
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of parathyroid hormone on delayed renal allograft function.
Authors: C J Ferguson, J D Williams, A Silver, J S Woodhead, J R Salaman
Journal: BMJ (1991)

Diabetic Association on reuse and insisted that they should be used only once.' Diabetic patients therefore received conflicting advice from the DHSS and high street chemists (who had an added financial incentive in advocating the single use of syringes) on the one hand, and from diabetic clinic staff on the other.Our present study shows that patients heeded the advice of clinic staff and continued to reuse syringes.Indeed, the frequency of reuse of syringes by these patients actually increased.No systematic advice was given to the patients and there is no obvious reason why the reuse of syringes increased over time.One possible explanation is that patients increased the reuse of syringes as their confidence and experience grew.This did not seem to be a conscious decision as most patients were unaware that they had increased their frequency of reuse.The conflict should now be resolved as the Department of Health has recently issued Drug Tariff Specification No 39A bearing the heading "Sterile Single Use or Single Patient Use," although it seems likely that the labels on the syringes will continue to read "For single use only."I Alexander aWD, Tattersall R. Plastic insulin sN ringes: reusc or waste i:8m a Near.
Diffuse Liver and Splenic Activity with Tc-99m MDP Associated with Iohexol Injection
Authors: THOMAS B. POULTON, JOHN N. RAUCHENSTEIN, WILLIAM D. MURPHY
Journal: Clinical Nuclear Medicine (1992)

POULTON, THOMAS B. M.D.; RAUCHENSTEIN, JOHN N. M.D.; MURPHY, WILLIAM D. M.D. Author Information
Adequate use of pulmonary embolism clinical prediction rule in COPD patients
Authors: L. Bertoletti, M. Righini
Journal: European Respiratory Journal (2010)

reflex cough peak flow and voluntary cough peak flow, there are few individuals (highlighted in circle, both patients and controls) in whom reflex cough flow is lower than voluntary cough flow, but, contrary to Widdicombe and Addington's proposal, there was none in whom reflex cough flow rate was greater than voluntary cough.
Systematic Review and Meta-analysis of Studies Reporting Urinary Continence Recovery After Robot-assisted Radical Prostatectomy
Authors: Vincenzo Ficarra, Giacomo Novara, Raymond C. Rosen, Walter Artibani, Peter R. Carroll, Anthony Costello, Mani Menon, Francesco Montorsi, Vipul R. Patel, Jens-Uwe Stolzenburg, Henk Van der Poel, Timothy G. Wilson, Filiberto Zattoni, Alexandre Mottrie
Journal: European Urology (2012)
Intranodal Administration of Peptide-Pulsed Mature Dendritic Cell Vaccines Results in Superior CD8<sup>+</sup>T-Cell Function in Melanoma Patients
Authors: Isabelle Bedrosian, Rosemarie Mick, Shuwen Xu, Harvey Nisenbaum, Mark Faries, Paul Zhang, Peter A. Cohen, Gary Koski, Brian J. Czerniecki
Journal: Journal of Clinical Oncology (2003)

Purpose: We evaluated the feasibility, safety, and immunogenicity of mature, peptide-pulsed dendritic cell (DC) vaccines administered by different routes. Patients and Methods: We performed a randomized, phase I, dose-escalation study in 27 patients with metastatic melanoma receiving four autologous peptide-pulsed DC vaccinations. Patients were randomly assigned to an intravenous (IV), intranodal (IN), or intradermal (ID) route of administration (ROA). For each route, primary end points were dose-limiting toxicity, maximum-tolerated dose, and T-cell sensitization. Sensitization was evaluated through tetramer staining, in vitro peptide recognition assays, and delayed-type hypersensitivity (DTH) responses. Results: Twenty-two (81.5%) of 27 patients completed all four vaccinations. Vaccinations were well tolerated; a few patients exhibited grade 1 to 2 toxicities including rash, fever, and injection site reaction. All routes of administration induced comparable increases in tetramer-staining CD8 + T cells (five of seven IV, four of seven IN, and four of six ID patients). However, the IN route induced significantly higher rates for de novo development of CD8 + T cells that respond by cytokine secretion to peptide-pulsed targets (six [85.7%] of seven IN patients v two [33%] of six ID patients v none [0%] of six IV patients; P = .005) and de novo DTH (seven [87.5%] of eight IN patients v two [33.3%] of six ID patients v one [14.3%] of seven IV patients; P = .01) compared with other routes. Conclusion: Administration of this peptide-pulsed mature DC vaccine by IN, IV, or ID routes is feasible and safe. IN administration seems to result in superior T-cell sensitization as measured by de novo target-cell recognition and DTH priming, indicating that IN may be the preferred ROA for mature DC vaccines.
Coarctation of the Aorta: Hemodynamic, Angiographic, and Anatomic Correlations.
Authors: D. Luke Glancy
Journal: Annals of Internal Medicine (1968)

s1 May 1968Coarctation of the Aorta: Hemodynamic, Angiographic, and Anatomic Correlations.D. Luke Glancy, M.D., William C. Roberts, M.D., Allan L. Simon, M.D., Eugene Braunwald, M.D., F.A.C.P., Andrew G. Morrow, M.D.D. Luke Glancy, M.D.Search for more papers by this author, William C. Roberts, M.D.Search for more papers by this author, Allan L. Simon, M.D.Search for more papers by this author, Eugene Braunwald, M.D., F.A.C.P.Search for more papers by this author, Andrew G. Morrow, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1155_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough many studies of coarctation of the aortic isthmus have been reported, none have correlated the hemodynamic, angiographic, and pathologic findings. Of 84 patients (62 male, 22 female; age range, 1 to 49 years, average, 17 years), all had murmurs; 78 had absent, diminished, or delayed femoral pulsations; 51 had cuff systolic blood pressures in the arm above 140 mm Hg, and 30 had diastolic pressures above 90 mm Hg. Fifty-two patients had angiograms. Average pressure gradients (millimeters of mercury) obtained by direct measurements above and below the coarctations in 35 patients were peak systolic, 44; mean, 17; diastolic, 5.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: D. Luke Glancy, M.D.; William C. Roberts, M.D.; Allan L. Simon, M.D.; Eugene Braunwald, M.D., F.A.C.P.; Andrew G. Morrow, M.D.Affiliations: Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPatient Study 36Cardiac Catheterization: II. Detection and Assessment of Common Cardio-vascular Abnormalities 1 May 1968Volume 68, Issue 5Page: 1155-1155KeywordsAngiographyAortaBlood pressureHemodynamics ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
MALT1 Protease: A New Therapeutic Target in B Lymphoma and Beyond?
Authors: Linda M. McAllister-Lucas, Mathijs Baens, Peter C. Lucas
Journal: Clinical Cancer Research (2011)

The identification of mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) as a gene that is perturbed in the B-cell neoplasm MALT lymphoma, already more than a decade ago, was the starting point for an intense area of research. The fascination with MALT1 was fueled further by the observation that it contains a domain homologous to the catalytic domain of caspases and thus, potentially, could function as a protease. Discoveries since then initially revealed that MALT1 is a key adaptor molecule in antigen receptor signaling to the transcription factor NF-κB, which is crucial for lymphocyte function. However, recent discoveries show that this function of MALT1 is not restricted to lymphocytes, witnessed by the ever-increasing list of receptors from cells within and outside of the immune system that require MALT1 for NF-κB activation. Yet, a role for MALT1 protease activity was shown only recently in immune signaling, and its importance was then further strengthened by the dependency of NF-κB-addicted B-cell lymphomas on this proteolytic activity. Therapeutic targeting of MALT1 protease activity might, therefore, become a useful approach for the treatment of these lymphomas and, additionally, an effective strategy for treating other neoplastic and inflammatory disorders associated with deregulated NF-κB signaling.