tbuckley/cabot-search huggingface dataset:
THE LIGHT SENSE, WITH SPECIAL REFERENCE TO NAVIGATION
Authors: A. F. Fergus
Journal: BMJ (1922)

Andrews constitute the climax of one of the remnarkable careers in the annals of present-day medicine.This work is beneficent, not only for the direct results it is achievina, but for its influence in bringing back men's minds to the fundamental importance of studying the patient-a stuly whiclh lhad become somewhat overshadowed by the advances in laboratory metlhods.From anotlher aspect biochemistry will, I venture to think, more and more tlhrow light on the changes premonitory of disease.By the co-ordination of the two methods of inquiry the sirest progress will be achieved.Correspon-ding to this trend of thoualgt within the profes- slon there is a notable change in the attitude of the public, in whose mind health has become a po3itive conception, and is no longer regarded as tlle same tlhing as freedom from disease.Strengthl and perfection of frame are coming to be reaarded as both a duty and pride of achievement, and people will pay more attention to digression from this hligh standard.To be too fat or purple and breathless in the prime of life will be the object of censure, just as now it is considered bad form to have a neglected mouth.As a result-if I may indulge in prophecy-methods of treatment will alter.For these early departures from health will not hostels of health replace -lhospitals to cure disease?While continuing his employment the man who is lapsing from anatomical or physiological rectitude will reside in a lhostel for a brief -space, and under a suitable regime of rest, .exercise,diet, training, and other treatment will be restored to tlhe joy of fitness.At present this growina sense of the value of health is too exclusively concerned withi the physical aspect.Tlle importance of mind liealth, however, will in time gain recognition unless its significance is obscured by wild advocacy.And that recognition will be followed by a greatly needed chanae in tlIin opinions and demands concern- ing popular recreations anlJ tisl lsments.ORGANIZATION OF MEDICAL INSTITUTIONS.In conclusion I will consider, briefly, developments whlicl affect our medical organization.Growtlh of mnedical knowledge and the increasing number of sciences associated witlh it are steadily making diagnosis and treatment rest on collective rather than individual efiforts.Collective effort, to be efficient and economical, needs to be aggregated into organizations.It follows tllat institutions especially equipped as hiospitals and clinics, with tlleir-labora- tories and accessories, will be necessary throuahout the
Abstract LB-401: The chemosensitizing properties of iniparib in combination with DNA-damaging agents in the MDA-MB-468(−) triple-negative breast cancer (TNBC) cell line
Authors: Valeria Ossovskaya, Chang-Uk Lim, Gary Schools, Swathi Kalurupalle, Igor B. Roninson, Eugenia Broude
Journal: Cancer Research (2011)

Abstract BACKGROUND: Iniparib (BSI-201) has demonstrated promising efficacy and safety in the treatment of patients with metastatic triple-negative breast cancer (TNBC). The addition of iniparib to gemcitabine (G) and carboplatin (C) improved the clinical benefit rate from 34% to 56% (P = 0.01) and the overall response rate from 32% to 52% (P = 0.02) in a phase II clinical study (O'Shaughnessy et al. N Engl J Med. 2011).We investigated the chemosensitizing properties of iniparib with irinotecan (I) or ionizing radiation (IR). METHODS: The chemosensitizing properties of a single dose of iniparib combined with I or IR were evaluated in TNBC MDA-MB-468 breast carcinoma cells. Cell proliferation was evaluated with FACS-based cell cycle analysis, including DNA staining and bromodeoxyuridine incorporation. RESULTS: FACS analysis showed that in TNBC MDA-MB-468 breast carcinoma cells iniparib potentiated cell cycle arrest induced by I, with cells arrested in S and G2/M phases, or potentiated cell cycle arrest induced by IR, with cells arrested mostly in G2/M, at 72 hours after treatment (Table 1). CONCLUSIONS: These data demonstrate the potentiation of the antiproliferative activity of I and IR by iniparib in TNBC MDA-MB-468 breast carcinoma cells. These data support investigation of iniparib in combination with these DNA-damaging agents in clinical studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-401. doi:10.1158/1538-7445.AM2011-LB-401
THE INFECTION OF FERRETS WITH SWINE INFLUENZA VIRUS
Authors: Richard E. Shope
Journal: The Journal of Experimental Medicine (1934)

The experiments described confirm the earlier observation of Smith, Andrewes, and Laidlaw that the swine influenza virus is pathogenic for ferrets when administered intranasally. A disease that is clinically more severe and pathologically more extensive than that described by the above workers is obtained if inoculation with the virus is performed under ether anesthesia. Animals infected in this way show at autopsy an edematous type of pneumonia of lobar distribution which may terminate fatally. The virus maintains its pathogenicity for ferrets when stored in 50 per cent glycerol at refrigerator temperature for as long as 75 days. After serial passage through 16 ferrets the virus is still capable of inducing swine influenza when mixed with H. influenzae suis and administered intranasally to swine. Ferret passage causes no apparent attenuation of the virus for swine. Serum from pigs recovered from swine influenza is capable of neutralizing the ferret-passaged virus for either swine or ferrets. Likewise serum from recovered ferrets neutralizes the swine influenza virus for either ferrets or swine.
Death By Decision: The Medical, Moral, and Legal Dilemmas of Euthanasia
Authors: Melvin J. Krant
Journal: JAMA (1975)

<h3>Beneficent Euthanasia</h3> edited by Marvin Kohl, 255 pp, $10.95, paper $4.95, Buffalo, NY (923 Kensington), Prometheus Books, 1975. The question of death is intimately bound to questions of the dying experience, and to the nature of human pain and suffering, the value of patience and endurance, and the potential for technical maintenance of a viable body in the absence of several critical determinants that describe a human being, namely, awareness, sentience, self-control. These two volumes present arguments that euthanasia be viewed in a positive sense. The essential position has been stated many times in the recent decades: that technology can extend the dying process for individuals with fatal illnesses of various kinds, but that this process of dying is not the same as meaningful living. Since this technology has been developed only lately, the philosopher, the ethicist, and the medical decision-makers are faced with quandaries that did not exist just
On the New French Codex
Authors: P. Squire
Journal: BMJ (1867)

again, after the admission of the second case, I found that the covered drain behind the outer grating was still blocked up with mud.This I again represented; and, in consequence, the covered drain, twenty-six feet long, was opened throughout, and found completely filled with mud, so that fluid could only percolate slowly through it.The barrack contractor told me that this drain had not been opened for the last fifteen years.I went in while they were preparing the new drain, and noticed that the back water in the open gutter contained soap, which first led me to the knowledge of the practice of washing the bedclothes in the open yard.These washings were the only source of organic matters in the drain, which, as I before said, was only intended for the surface rain water.The drain was remodeled on July 21st.An artillery-stable had recently been made in the forage-yard, and this was separated from the light labour shed, by a wooden partition, through which the smell of stables was very perceptible.I mention this that no circumstance may be omitted; but with- out attributing any value to it as determining the fever, which seems to me most probably due to the obstruction of the drain, and to gaseous emanations through the grating which was at the angle of junc- tion of the hard labour and light labour sheds, the former being on the side of the reserve-ground, the latter on the side of the forage-yard.An instance such as this tends strongly to confirm the view, that enteric fever may originate from putrid emanations unconnected with fwcal contamination or sewage.
Dream production is not chaotic
Authors: Mauro Mancia
Journal: Behavioral and Brain Sciences (2000)

The AIM model proposed by Hobson et al. is interesting: We know the neurophysiological aspects of the activation process (A) and the external input (I), but very little about the internal input and neurocognitive process (M). Internal input could be an expression of unconscious experiences memorised by the subject containing his emotional and cognitive history. Therefore internal input could not be chaotic but might have an emotional and affective sense bound to the unconscious. The fact that dreams are present in the absence of REM sleep means that they may originate from other structures besides the pons. These structures may represent the archives of dreamer's affective history. [Hobson et al.; Solms]
[154] SURVIVAL ANALYSIS OF HIV INFECTED PATIENTS REFERRED TO A LIVER TRANSPLANT UNIT
Authors: J.C. Duclos-Vallee, V. Delvart, F. Blandin, E. Teicher, T. Antonini, D. Azoulay, B. Roche, F. Saliba, P. Ichai, R. Adam, D. Castaing, D. Vittecoq, D. Samuel
Journal: Journal of Hepatology (2007)
Acute overuse injury:- a case of tenosynovitis
Authors: J. G. P. Williams
Journal: British Journal of Sports Medicine (1971)

The patient C.B. presented with pain, swelling and creaking on the dorsum of the right forearm.Two weeks previously he had taken part in the 126 mile Devizes to Westminster Canoe race which, with his partner, he had won in record time under rather unfavourable weather conditions.
Dietary Microbes Modulate Transgenerational Cancer Risk
Authors: Theofilos Poutahidis, Bernard J. Varian, Tatiana Levkovich, Jessica R. Lakritz, Sheyla Mirabal, Caitlin Kwok, Yassin M. Ibrahim, Sean M. Kearney, Antonis Chatzigiagkos, Eric J. Alm, Susan E. Erdman
Journal: Cancer Research (2015)

Abstract Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer. Cancer Res; 75(7); 1197–204. ©2015 AACR.
SURFACE ALLOANTIGENS OF PLASMA CELLS
Authors: Toshitada Takahashi, Lloyd J. Old, Edward A. Boyse
Journal: The Journal of Experimental Medicine (1970)

A serological study of immunoglobulin-forming cells of the mouse, normal and malignant, shows that they lack all known surface differentiation antigens of the thymocyte-lymphocyte axis: TL, theta, Ly-A, Ly-B, and MSLA. Two systems of normal alloantigens are expressed on these cells, H-2 and a new system named PC. The gene Pca (Plasma cell antigen) which specifies PC.1 alloantigen segregates as a mendelian dominant not closely linked with H-2. This cell surface antigen is absent from thymocytes, leukemias, and very probably from thymus-derived lymphocytes also; it is present on cells of the liver, kidney, brain, and lymph nodes as well as on hemolytic plaque-forming cells of the spleen, and on myelomas. So PC.1 is properly classified as a differentiation alloantigen. The strain distribution of PC.1 does not conform to that of any known immunoglobulin allotype or cell surface alloantigen previously described. Thus the cell surface antigens of immunoglobulin-producing cells are clearly different from those of cells belonging to the thymocyte-lymphocyte axis. Each family of cells has distinctive alloantigens, and the two families share alloantigens of only one known system, H-2. This implies that either immunoglobulin-producing cells are not derived from thymic lymphocytes, or if they are, the program responsible for the transition must include extensive revision of cell surface structure.
A clinico-immunological study of ulcerative colitis and ulcerative proctitis
Authors: A. H. Smith, I. W. Macphee
Journal: Gut (1971)

Fifteen patients with ulcerative colitis and 11 patients with ulcerative proctitis have been observed and studied for periods ranging from one to 15 years. It is suggested that the clinical course of the two disorders is quite distinct. Further, while the serum immunoglobulins were within normal limits in ulcerative proctitis, significant increases in the serum alpha(2)-, beta-, and gamma-globulins and in the IgA and IgG concentrations were found in ulcerative colitis. Despite total colectomy for ulcerative colitis, the serum IgG and IgA concentration remained high and even after subsequent rectal resection the relative IgA concentration continued to increase. The significance of these findings is discussed.
Using T Cells to Treat B-Cell Cancers
Authors: Judy Lieberman, Rachel J. Buchsbaum
Journal: New England Journal of Medicine (1994)

The Epstein-Barr virus (EBV), a ubiquitous herpesvirus estimated to infect 90 percent of the world's population,1 has been linked to a growing number of diseases, especially in immunocompromised hosts. The first ties between neoplastic disease and EBV were discovered in Burkitt's lymphoma2 and nasopharyngeal carcinoma. The virus has also been found in immunoblastic lymphomas in allograft recipients and persons infected with the human immunodeficiency virus (HIV),3 and in the oral hairy leukoplakia of AIDS. Recently, the EBV genome has been detected in Reed-Sternberg cells in some cases of Hodgkin's disease4 and in KI-1+ lymphoma, various T-cell lymphomas, thymic carcinoma, and . . .
Surgical Management of Cerebrovascular Disease
Authors: Julian T. Hoff
Journal: JAMA (1984)

This book offers guidelines for the surgical management of cerebrovascular diseases, based on the authors' clinical experience at the Massachusetts General Hospital, Boston. Each of its 25 chapters includes a discussion of clinical signs and symptoms, current diagnostic techniques, illustrative case descriptions, and various treatment options. Complications of treatment and outcome conclude each chapter. Surgical techniques used at Massachusetts General Hospital are described and clearly illustrated. The first nine chapters concern occlusive cerebrovascular disease. The remaining 16 offer concise discussions of the surgical management of aneurysms, arteriovenous anomalies, and brain hemorrhage. The book is thorough but not exhaustive, practical, and up to date. It is well written and nicely illustrated. Color photographs, line drawings, and roentgenograms of excellent quality are featured. Controversial issues, such as carotid endarterectomy for acute stroke and asymptomatic bruit, are presented in an unbiased and well-balanced fashion. Physicians and surgeons who treat patients with stroke would
Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate
Authors: Zhixiang Liu, Jingfeng Zhou, Yi Li, Fei Hu, Yao Lu, Ming Ma, Qiru Feng, Ju-en Zhang, Daqing Wang, Jiawei Zeng, Junhong Bao, Ji-Young Kim, Zhou-Feng Chen, Salah El Mestikawy, Minmin Luo
Journal: Neuron (2014)
Cardiovascular effects of fish oils. Beyond the platelet.
Authors: A Leaf
Journal: Circulation (1990)

T here has been considerable interest recently in the potential of fish oils to prevent coronary artery disease.The article by Braden et al, "Dietary Fish Oil Accelerates the Response of Cor- onary Thrombolysis With Tissue Plasminogen Acti- vator: Evidence for a Modest Platelet Inhibitory Effect In Vivo" in a recent issue of Circulation' is another in a series of rigorous studies on the effects of fish oils on experimental thrombosis performed by these Vanderbilt University investigators.They have nicely demonstrated that feeding high levels of the two important polyunsaturated fatty acids of fish oils, namely eicosapentaenoic acid (EPA) (C20: 5w-3) and docosahexaenoic acid (DHA) (C22: 6c-3), sig- nificantly shortens the time for recombinant tissue- type plasminogen activator (rt-PA) to cause reperfu- sion in thrombosed coronary arteries in dogs.However, the high intake of fish oils failed to delay the development of an occluding thrombus when the endothelial surface of a cannulated coronary artery was injured electrically and failed to reduce the incidence of reocclusion as compared with control animals fed the usual dog chow.The study was designed, as the investigators state, "to determine whether fish oils inhibited plateletdependent events in vivo."It was nicely designed for that purpose.However, that is not to say that it was ideally designed to isolate the effects of only throm- boxane and prostacyclin on the parameters mea- sured.In any in vivo manipulation that results in a blood clot and its lysis, one must consider the potent effects of thrombin on platelet aggregation, as well as those of thromboxane.Thrombin is a more aggressive aggregator of platelets than is thromboxane.Aspirin will inhibit platelet aggregation caused by thrombox- ane, but thrombin will aggregate platelets even in the presence of aspirin except at very low concentrations.In a recent study, Fitzgerald, Wright, and FitzGerald2 used this same canine model to examine the effect of a dose of aspirin that was selected to achieve a more than 95% inhibition of serum throm- boxane B2 (TXB2) in the dog.Compared
Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis
Authors: Sylvia Hofmann, Andre Franke, Annegret Fischer, Gunnar Jacobs, Michael Nothnagel, Karoline I Gaede, Manfred Schürmann, Joachim Müller-Quernheim, Michael Krawczak, Philip Rosenstiel, Stefan Schreiber
Journal: Nature Genetics (2008)
Antitumor Activity and Bystander Effect of Adenovirally Delivered Tissue Inhibitor of Metalloproteinases-3
Authors: Matti Ahonen, Risto Ala-Aho, Andrew H. Baker, Sarah J. George, Reidar Grénman, Ulpu Saarialho-Kere, Veli-Matti Kähäri
Journal: Molecular Therapy (2002)

We have studied the effect of a newly identified tumor suppressor tissue inhibitor of metalloproteinases- 3 (TIMP-3) on the growth of human melanoma and squamous-cell carcinoma (SCC). Adenoviral delivery of the TIMP-3 gene to human melanoma (A2058) and SCC (UT-SCC-7) cells ex vivo inhibited tumorigenesis after subcutaneous (s.c.) injection of the infected cells into SCID/SCID mice. Three daily consecutive intratumoral injections of 1.4×109 plaque-forming units (pfu) of TIMP-3 adenovirus (RAdTIMP-3) inhibited the growth of preestablished melanoma and SCC xenografts in SCID/SCID mice, whereas growth of control virus-injected tumors was not affected. The antitumor effect of RAdTIMP-3 was obtained with in vivo adenoviral transduction efficiency of 8–10%, and it was more potent than that of adenovirally delivered p53. Adenovirusmediated expression of TIMP-3 potently reduced gelatinolytic activity, increased the number of apoptotic cells, and inhibited vascularization of melanomas. Escalation of the adenoviral dose to three rounds of three daily consecutive injections with 1.4×109 pfu of RAdTIMP-3 every 6 days entirely inhibited growth of injected melanomas for 32 days. Mixing RAdTIMP-3-infected A2058 cells with uninfected cells in 1:1 ratio in culture resulted in death of all cells in 96 hours. Adenovirally delivered TIMP-3 was also expressed by A2058 cells in soluble form into the culture medium, where it exerted a cytotoxic effect on uninfected A2058 cell cultures after relocating to the cell layer. These results identify TIMP-3 as a novel type of secreted tumor suppressor, which has antiinvasive, antiangiogenic, and proapoptotic effects in vivo, and which displays a potent bystander effect validating further exploration of its applicability in human cancer gene therapy.
Low nuclear MAD2 expression is associated with of lack of response to chemotherapy and radiotherapy in oestrogen receptor negative breast cancer patients
Authors: Elma Anna O'Reilly, Shiva Sharma, Michele Harrison, Karolina Weiner-Gorzel, Ciara Kelly, Aoife Maguire, Janet McCormack, Susie Conlon, Susan Aherne, Caitlin Beggan, Richard Bambury, Tiffany Dorsey, Stefan Ambs, Darran O'Connor, John McCaffrey, Reem Salman, Sharon A. Glynn, Fiona Furlong, Amanda McCann, Malcolm Kell, Cecily Quinn, Rut Klinger
Journal: International Journal of Surgery (2013)
Trusts fail to discipline those who manipulate waiting lists
Authors: A. Ferriman
Journal: BMJ (2002)

Public confidence in the NHS has been undermined by the way that waiting lists have been deliberately manipulated, Edward Leigh MP, chairman of the Committee of Public Accounts, said this week at the publication of the committee's two latest reports.

The committee found that arrangements for identifying those responsible for manipulating lists and for taking disciplinary action fell well short of good practice.

The reports said that although there had been …
Cyclosporin in the treatment of paltno-plantar pustulosis
Authors: S. Reitamo, P. Puska, A. Lassus
Journal: British Journal of Dermatology (1989)

Journal Article Cyclosporin in the treatment of paltno‐plantar pustulosis Get access S. Reitamo, S. Reitamo Helsinki University Central Hospital, Department of Dermatology, Snellmaninkatu 14, SF‐00170 Helsinki, Finland. Search for other works by this author on: Oxford Academic Google Scholar P. Puska, P. Puska Helsinki University Central Hospital, Department of Dermatology, Snellmaninkatu 14, SF‐00170 Helsinki, Finland. Search for other works by this author on: Oxford Academic Google Scholar A. Lassus A. Lassus Helsinki University Central Hospital, Department of Dermatology, Snellmaninkatu 14, SF‐00170 Helsinki, Finland. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 120, Issue 6, 1 June 1989, Page 857, https://doi.org/10.1111/j.1365-2133.1989.tb01389.x Published: 01 June 1989
CLINICAL PHYSIOPATHOLOGY.THE NEED OF A NEW CLASSIFICATION OF DISEASES OF THE NERVOUS SYSTEM.
Authors: L. HARRISON METTLER
Journal: JAMA (1907)

One who meets large numbers of undergraduates in the class room and general practitioners in consultation is often confronted with the assertion that neurology is the hardest, or at least one of the hardest, branches of scientific medicine to comprehend. Some genuine difficulties must be present in order to account for the prevalence of such an opinion. It would be absurd to assume that so many intelligent men can not grasp what to others of no greater mental capacity seems so easy of comprehension and so self-evident. The view has been expressed, and in my judgment rightly so, that for preciseness, reasonableness and scientific accuracy the teachings and findings of modern neurology give this department of medicine a rank second only to that of ophthalmology. If this view be but approximately correct, then it would seem that many intelligent men are not as capable as they appear to be, or