Renal Lesions in Wegener's Granulomatosis
Authors: DAVID RUBIN
Journal: Annals of Internal Medicine (1975)

Comments and CorrectionsJune 1, 1975Renal Lesions in Wegener's GranulomatosisDAVID RUBIN, PHIL PETERSON, M.D., JAY I. MELTZER, M.D.DAVID RUBINSearch for more papers by this author, PHIL PETERSON, M.D.Search for more papers by this author, JAY I. MELTZER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-849 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the NIH conference on Wegener's granulomatosis (Ann Intern Med81:513-525, 1974), one of the authors (Dr. Horn) concludes that the renal lesions are the result of "immune complex deposition (that) probably triggers focal and segmental injury to the glomerulus." He supports this view by citing electron microscopic findings of subepithelial deposits and immunofluorescence studies showing IgG and complement.Concerning the electron microscopic evidence, the author states that subepithelial deposits were found in only 3 of 19 specimens in their own series. This is the largest series in the literature and is not in disagreement with other...References1. NORTONSUKISTRUNK WWS: Combined corticosteroid and azathioprine therapy in two patients with Wegener's granulomatosis. Arch Intern Med 121:554-560, 1968 CrossrefMedlineGoogle Scholar2. FAUCIWOLFF AS: Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine (Baltimore) 52:535-561, 1973 CrossrefMedlineGoogle Scholar3. BARRDANIELSSONMAGNUSSON JDP: Wegeners granulomatos, 3 fall—klinik och immunofluorescens. Nord Med 86:1291, 1971 MedlineGoogle Scholar4. MGH Case Records (Case 15-1969). N Engl J Med 280:828-834, 1969 CrossrefMedlineGoogle Scholar5. FULLEROLSENBLOCK TNA: Wegener's granulomatosis treatment with heparin in addition to azathioprine and corticosteroids. Nephron 9:225-234, 1972 CrossrefMedlineGoogle Scholar6. MCINTOSHTINGLOFKAUFMAN RBD: Immunohistology in renal disease—diagnostic, prognostic, therapeutic and etiologic value and limitations. Q J Med 159:385, 1971 Google Scholar7. MOREL-MAROGERLEATHEMRICHET LAG: Glomerular abnormalities in nonsystemic diseases—relationship between findings by light microscope and immunofluorescence in 433 renal biopsy specimens. Am J Med 53:170 1972 CrossrefMedlineGoogle Scholar8. GERMUTHPOLLACK FA: Immune complex disease III—the granulomatous lesions. Johns Hopkins Med J 121:254, 1967 MedlineGoogle Scholar1. BURKHOLDER P: Atlas of Human Glomerular Pathology. Hagerstown, Maryland, Harper and Row, Inc. 1974 Google Scholar2. GERMUTHRODRIGUEZ FE: Immunopathology of the Renal Glomerulus. Boston, Little, Brown and Co., 1973 Google Scholar3. MCCLUSKEY R: Immunologic mechanisms in renal disease, in Pathology of the Kidney, 2nd ed. Edited by HEPTINSTALL RH. Boston, Little, Brown and Co., 1974, p. 276 Google Scholar4. HORNFAUCIROSENTHAL RAA: Renal biopsy pathology in Wegener's granulomatosis. Am J Pathol 74:423-434, 1974 MedlineGoogle Scholar5. MCCLUSKEY R: Case records of the Massachusetts General Hospital. N Engl J Med 291:1079, 1974 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nephrology Division Department of Medicine Columbia University 622 West 168th Street New York, New York 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 1, 1975Volume 82, Issue 6Page: 849-850KeywordsElectron microscopy Issue Published: June 1, 1975 PDF DownloadLoading ...