tbuckley/cabot-search huggingface dataset:
Relationship of Ornithine Decarboxylase activity and histological findings in human hepatocellular carcinoma
Authors: Akihiro Tamori, Shuhel Nishiguchi, Tetsuo Kuroki, Shuichi Seki, Kenzo Kobayashi, Hiroaki Kinoshita, Shuzo Otani
Journal: Hepatology (1994)

To evaluate the correlation between the polyamine metabolism and the degree of malignancy in hepatocellular carcinoma, we measured ornithine decarboxylase activity and polyamine concentrations in neoplastic tissue and adjacent noncancerous tissue from resected specimens of liver from 30 patients. Ornithine decarboxylase activity, polyamines (putrescine, spermidine and spermine) and ornithine decarboxylase mRNA levels were significantly higher in hepatoma tissue than in noncancerous tissue. The activity of this enzyme in the tumor tissue had a negative correlation with the histological degree of differentiation judged according to a modification of the Edmondson and Steiner classification. Resected hepatoma tissue was stained immunohistochemically with antibodies for proliferating cell nuclear antigen (also called cyclin), a marker of cell proliferation. We noted correlation between ornithine decarboxylase activity and the number of cells stained for this antigen (r = 0.882, p < 0.001). These results indicate that ornithine decarboxylase activity is high in human hepatocellular carcinoma, leading to increased intracellular concentrations of polyamines. Ornithine decarboxylase activity also reflected the rate of tumor proliferation and was correlated with the histological findings.
Multifocal Osteoarticular Tuberculosis Resembling Skeletal Metastatic Disease Evaluation With Tc-99m MDP and Ga-67 Citrate
Authors: RUTH HARDOFF, MOSHE EFRAT, SARA GIPS
Journal: Clinical Nuclear Medicine (1995)

Extrapulmonary tuberculosis Is uncommon In the western world. In the United States, skeletal involvement accounts for 1-2% of all cases of tuberculosis and about 10% of extrapulmonary disease. As a result of lymphohematogenous dissemination, infection of bone and joints with Mycobacterlum tuberculosis occurs concomitantly with the pulmonary Infection. Because malignant bone disease is more common even in children, the diagnosis of tuberculosis may be delayed. Ga-67 scintigraphy is generally used for follow-up in soft tissue and bone infection. However, its pattern in multifocal osteoarticular tuberculosis has not been reported. The authors describe the scintlgraphic patterns of bone and Ga-67 imaging in a 12-year-old girl with multifocal bone and joint tuberculosis.
Traitement endoscopique des sténoses iléales, coliques ou rectales bénignes post opératoires par dilatation associées à des injections locales de corticoïdes. Faisabilité et évolution
Authors: A Baju, L Lefrou, JP Barbieux, EH Metman
Journal: Endoscopy (2007)

Les injections intralésionnelles de corticoïdes de longue durée d'action sont proposées dans la prise en charge endoscopique des sténoses oesophagiennes car elles permettent de diminuer le nombre de séances de dilatations nécessaires. Il n'existe que peu de données concernant leur utilisation au niveau du tractus digestif inférieur. Le but de cette étude rétrospective était d'évaluer la faisabilité et de décrire l'évolution à long terme des dilatations endoscopiques associées à des injections de corticoïdes dans la prise en charge des sténoses bénignes survenues sur des anastomoses chirurgicales situées au niveau iléal, colique ou rectal.
Centralisation of cancer services vindicated
Authors: P. J. Cathcart, J. v. d. Meulen, M. Emberton, J. Kelly
Journal: BMJ (2010)

Mayer and colleagues evaluated the relation between volume and mortality for radical cystectomy in England.1 Their finding—that patients undergoing surgery in medium volume hospitals have a poorer outcome than those in low volume hospitals—contrasts with most published data.2 3

A weakness of Mayer and colleagues’ study is …
Cryotherapy for skin cancer: results over a 5-year period using liquid nitrogen spray cryosurgery
Authors: P. J. A. HOLT
Journal: British Journal of Dermatology (1988)

Three hundred and ninety five selected non-melanoma skin cancers were treated and followed up during the period 1981-1986, using a standardized cryosurgical technique. There was an overall cure rate of 97%. Recurrences were seen in 6 out of 225 (2.7%) treated basal cell carcinomas at a median time of 18 months, 1 of 34 (2.9%) squamous cell carcinomas, with a recurrence at 6 months post-operatively and 1 out of 128 (0.8%) of Bowen's tumours which recurred 6 months after treatment. The patients were treated as out-patients using local anaesthesia and all tolerated the treatment well. This study has shown that cryosurgery is a safe, low cost and effective method of treating selected non-melanoma skin cancer and produced excellent cosmetic results with a high cure rate. It is suggested that patients treated with cryosurgery are followed up carefully for 2 years post-operatively.
Diagnostic Value of Differential Expression of CK19, Galectin-3, HBME-1, ERK, RET, and p16 in Benign and Malignant Follicular-Derived Lesions of the Thyroid: An Immunohistochemical Tissue Microarray Analysis
Authors: J. E. Barroeta, Z. W. Baloch, P. Lal, T. L. Pasha, P. J. Zhang, V. A. LiVolsi
Journal: Endocrine Pathology (2006)
Electroporation for the Delivery of DNA-based Vaccines and Immunotherapeutics: Current Clinical Developments
Authors: Angela M Bodles-Brakhop, Richard Heller, Ruxandra Draghia-Akli
Journal: Molecular Therapy (2009)

This review demonstrates the wide-reaching ability of DNA delivery with EP to treat or prevent numerous diseases. The continued research into this approach will enable this technology to be applied to many more conditions that are lacking effective therapies. Recently, the technique of EP itself, independent of DNA delivery, has been shown to recruit and trigger cells involved in antigen presentation and immune response.81Chiarella P Massi E De Robertis M Sibilio A Parrella P Fazio VM et al.Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration.Expert Opin Biol Ther. 2008; 8: 1645-1657Crossref PubMed Scopus (70) Google Scholar Therefore, EP has adjuvant-like properties that will enhance the continued development and success of DNA vaccines and immunotherapeutics. The results from the current phase I studies will provide important safety information as well as preliminary efficacy data in humans for EP-assisted delivery of plasmid DNA enabling the transition to phase II and III studies and ultimately for use in clinical practice. Interim data from some of the current clinical trials as discussed suggest that the technique of EP for the administration of DNA vaccines and immunotherapies is a powerful tool for combating diseases. Not only does EP enhance humoral and cellular immune responses, but it also decreases injection volume, minimizes the number of applications, and prolongs the vaccine or therapeutic effects. The route of administration will also likely play a large role in the transition of EP to humans. Although most preclinical studies to date have centered on IM applications, the ID route of application will likely be more readily accepted by the majority of the population. Together with the fact that skin administration has been the status quo for vaccinations, the ease of accessibility and the reduced pain level compared to IM injections may increase public acceptance. Evolution of the EP device itself from a lab-like instrument to an esthetically pleasing, biosafe medical tool that is easily operated and portable with low-cost disposables will also be necessary for its future widespread use. Therefore, the further development and application of EP will be of significant importance in administration of vaccines to the public, in terms of compliance and economical feasibility.
Placebo-Controlled Trials
Authors: Robert Temple, Susan S. Ellenberg
Journal: Annals of Internal Medicine (2001)

Letters3 July 2001Placebo-Controlled TrialsRobert Temple, MD and Susan S. Ellenberg, PhDRobert Temple, MDU.S. Food and Drug Administration; Rockville, MD 20857 (Temple, Ellenberg)Search for more papers by this author and Susan S. Ellenberg, PhDU.S. Food and Drug Administration; Rockville, MD 20857 (Temple, Ellenberg)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-1-200107030-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Djulbegovic argues that the principle of equipoise must be of particular concern in placebo-controlled trials because placebo-treated patients may be disadvantaged and should not “sacrifice themselves for the benefit of others.” It seems important, as we emphasized in our papers, to distinguish between studies of treatments for serious illness and studies of symptomatic treatments. Exposure to placebo in the former requires genuine uncertainty about the outcome. Exposure to placebo in a trial of headache, anxiety, or seasonal allergy, however, cannot reasonably be said to constitute “sacrifice” of oneself. It is, at worst, the sort of choice to ... Author, Article, and Disclosure InformationAffiliations: U.S. Food and Drug Administration; Rockville, MD 20857 (Temple, Ellenberg) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPlacebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 1: Ethical and Scientific Issues Robert Temple and Susan S. Ellenberg Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 2: Practical Issues and Specific Cases Susan S. Ellenberg and Robert Temple Placebo-Controlled Trials Benjamin Djulbegovic Metrics 3 July 2001Volume 135, Issue 1Page: 63-64KeywordsAnxietyCancer chemotherapyCancer treatmentChemotherapyCyclophosphamideDrugsHeadachesMorbidityPatientsPopulation statistics ePublished: 3 July 2001 Issue Published: 3 July 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Mantle Cell Lymphoma 12 Years After Allogeneic Bone Marrow Transplantation Occurring Simultaneously in Recipient and Donor
Authors: Beth Christian, Weiqiang Zhao, Mehdi Hamadani, Eduardo M. Sotomayor, Willis Navarro, Steven M. Devine, Frederick Racke, Kristie A. Blum
Journal: Journal of Clinical Oncology (2010)
Are There Really Alternatives to the Use of Fetal Tissue from Elective Abortions in Transplantation Research?
Authors: D J Garry, A L Caplan, D E Vawter, W Kearney
Journal: New England Journal of Medicine (1992)

Researchers believe fetal tissue can be easily transplanted into and cure people with incurable debilitating diseases such as Parkinson's disease. In 1988, the Reagan Administration stopped funding transplantation research of fetal tissue from induced abortions. An advisory panel later decided that it is an acceptable public policy as long as certain conditions a re met. Yet the Bush Administration continued the ban. In 1992, it erroneously claimed that transplantation research could use alternative sources of fetal tissue. 1 alternative is fetal tissue obtained from ectopic pregnancies. Yet spontaneously aborted ectopic pregnancies tend not to produce recognizable or viable in culture fetal tissue and if they do the tissue has been ischemic for days. Ectopic pregnancies requiring surgical sterilization tend to be morphologically abnormal. The only likelihood of viable fetal tissue form ectopic pregnancies is a fetus with myocardial contractility before surgery. The administration also recommended use of fetal tissue from spontaneous abortions but these fetuses often have a major chromosomal or other fatal defect. Researchers cannot use chromosomally abnormal fetal tissue since it growth, development, and function are unreliable. Expulsion of the necrotic fetus tends to occur a couple of weeks after death. The Bush Administration also proposed use of tissue from stillbirths but their tissue tends to be nonviable and the tissue, even if it were viable, is generally not at the developmental stage needed for transplantation. The placenta and yolk sac were other suggested alternatives, but the placenta is likely to be less immunogenic than embryonic tissue. It can help develop certain cell lines which produce insulin or neurotransmitters like dopamine, however. The yolk sac could replace fetal liver cells in transplantation. Nevertheless the only advantage of using the suggested alternatives is the perception of them raising less ethical concern than fetal tissue from an induced abortion.
The Use of in Vitro Technics to Study Drug-Induced Pancytopenia
Authors: John G. Kelton, Andrew T. Huang, Nelda Mold, Gerald Logue, Wendell F. Rosse
Journal: New England Journal of Medicine (1979)

The confirmation of drug-induced marrow aplasia is difficult since rechallenging the patient can lead to serious morbidity. We used marrow-culture technics to challenge in vitro the bone marrow of a patient with marrow aplasia after ingestion of quinidine. There was no clinical or laboratory evidence of quinidine-mediated destruction of erythrocytes, leukocytes or platelets. By contrast, use of quinidine in combination with the patient's serum substantially inhibited in vitro growth of allogeneic marrow granulocytic and erythroid series. Furthermore, use of quinidine in combination with acute-phase serum (but not acute-phase serum alone or quinidine in combination with recovery-phase serum) inhibited growth of the patient's marrow. This observation suggests that both a transient serum factor and quinidine were responsible for the marrow aplasia. These technics could be applied with minimal risk to similar patients and would permit in vitro rechallenge with the suspected drug.
Abstract A05: Ubiquilin1 represses migration and epithelial to mesenchymal transition of human non-small cell lung cancer cells.
Authors: Parag P. Shah, William W. Lockwood, Kumar Saurabh, Zimple Kurlawala, Sabine Waigel, Wolfgang Zacharias, Levi J. Beverly
Journal: Clinical Cancer Research (2014)

Abstract Ubiquilin1 (UBQLN1) is a ubiquitin-like domain and a ubiquitin-associated domain containing protein that has been reported to be involved in shuttling proteins to the proteasome, especially during endoplasmic reticulum-associated protein degradation (ERAD). Thus, UBQLN1 function has been shown to be critical for combating a number of neurological disorders caused by protein aggregation, such as Amyotrophic lateral sclerosis (ALS), Alzheimer's disease and Huntington's disease. A role for UBQLN1 in regulating processes involved in tumorigenesis has not been demonstrated. Herein, we show that loss of UBQLN1 causes increased cell migration and invasion, actin cytoskeleton reorganization and induction of epithelial mesenchymal transition (EMT). Loss of UBQLN1 results in a significant decrease in the expression of epithelial markers including E-cadherin and claudin1, whereas expression of mesenchymal markers including Vimentin, Snail and ZEB1 are significantly elevated. Interestingly, we found that ZEB1 is required for induction of mesenchymal-like properties following loss of UBQLN1 and ZEB1 is capable of repressing expression of UBQLN1, suggesting a physiological, reciprocal regulation of EMT by UBQLN1 and ZEB1. Furthermore, we observed that loss of UBQLN1 sensitizes lung cancer cells to treatment with cytotoxic drugs. These observations have potential clinical relevance because the UBQLN1 gene is lost and under-expressed in a large percentage of human cancer cell lines and primary human lung cancer samples. Taken together, our results suggest for the first time a role of UBQLN1 in the regulation of EMT and a potential role in cancer biology and in predictive cancer therapeutics. Citation Format: Parag P. Shah, William W. Lockwood, Kumar Saurabh, Zimple Kurlawala, Sabine Waigel, Wolfgang Zacharias, Levi J. Beverly. Ubiquilin1 represses migration and epithelial to mesenchymal transition of human non-small cell lung cancer cells. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr A05.
Latex allergy in health‐care workers in an English district general hospital
Authors: None Handfield‐Jones
Journal: British Journal of Dermatology (1998)

Immediate hypersensitivity to latex protein is a serious and potentially life-threatening problem. This study found that eight of 867 (0.9%) medical and nursing staff in a district general hospital were allergic to latex with resultant hand eczema and/or urticaria. Wheezing occurred when latex became airborne, adsorbed to starch powder. Sensitized individuals are at risk of anaphylaxis when they themselves become patients. Measures to prevent latex sensitization include pre-employment advice regarding hand care and glove use, particularly for atopics, who are at increased risk. Gloves made from synthetic latex must be available for a sensitized individual, both to use at work and when undergoing medical examinations, surgery and dentistry. Increased awareness of the problem by health-care workers is important in order to recognize those at risk.
Henry ("Harry") Tubmen
Authors: M. Hickson
Journal: BMJ (2003)

Former general practitioner Pelton, County Durham (b Hetton-le-Hole, Tyne and Wear, 1928; q Durham 1951), died from cryptogenic cirrhosis and diabetes on 24 June 2002.

Henry completed his house jobs at Newcastle, and subsequently spent two years doing national service in Malaya. On returning to England, he worked in obstetrics before joining general practice, where he worked until his retirement in 1990. He was a medical officer in the Territorial Army for many years and was awarded the Territorial Decoration. He leaves a wife, Jeanette, and two children.
The Decision to 'Unmedicate'
Authors: Walter Flamenbaum
Journal: JAMA (1985)

Inherent in prescribing drugs is a decision that the benefit resulting from therapy is greater than the risk associated with a given medication. A corollary of this concept should be an ongoing review of whether it is necessary to continue the administration of a particular drug indefinitely, or whether it is safe to "unmedicate" under certain circumstances. Reviews of this type have shown, for example, that adult epileptics taking phenytoin can be unmedicated with impunity in 60% of the cases.<sup>1</sup>Another well-accepted but controversial precept of medical care concerns the role of nonpharmacologic therapy for patients with hypertension. Specifically, the effect of weight reduction and sodium restriction on the drug treatment of hypertension, and the resultant influence on morbidity and mortality, remains incompletely elucidated. Langford and co-workers<sup>2</sup>report in this issue ofThe Journalthe results of a study designed to determine whether patients receiving aggressive antihypertensive therapy
The Total Eosinophil Count in Obstructive Pulmonary Disease
Authors: Francis C. Lowell
Journal: New England Journal of Medicine (1975)

The article by Horn et al. in this issue of the Journal presents data on some clinical uses of the total eosinophil count confirming some earlier observations. These data establish the count as a useful laboratory test in the diagnosis and management of obstructive pulmonary disease. The following discussion is based on their observations and those of others, including our extensive experience with the total eosinophil count in the Allergy Unit of the Massachusetts General Hospital.The count has a wide range in asthma, often exceeding 1000 per cubic millimeter. The lower values in asthma (350 to 400 per cubic . . .
HCV NS5A (1b) mutants show different phosphorylations pattern, inhibitinterferon (IFN) antiviral activity, but do not affect PKR and cellproliferation status
Authors: P. Podevin, A. Sabile, R. Gajardo, A. Abadie, F. Leone, C. Bréchot, L. Béretta
Journal: Journal of Hepatology (2000)
An ACE inhibitor reduces Th2 cytokines and TGF-β1 and TGF-β2 isoforms in murine lupus nephritis
Authors: Deijanira Alves De Albuquerque, Vijay Saxena, David E. Adams, Gregory P. Boivin, Hermine I. Brunner, David P. Witte, Ram Raj Singh
Journal: Kidney International (2004)
STERILIZING WATER AND MILK IN HERMETICALLY SEALED BOTTLES.
Authors: W. E. GAMBLE
Journal: JAMA (1894)

Professor C. A. Cary of Auburn, Ala., while visiting me last summer, called my attention to a sterilizer of water and milk which he had originated. His method is a new one to me, and I think to the rest of the profession; it consists in the use of hermetically sealed bottles. I have used a simple contrivance which has served me much better than any other sterilizer. I use pint beer bottles with "lightning stoppers." (Fig. A.) They can be obtained of any liquor dealer or grocer. The bottles are placed in a vessel (Fig. C), a six quart tin bucket is a suitable size for family use, as about six pints of milk or water can be sterilized at a time. The lid of the bucket has six one and one-half inch openings through which the necksof the bottles pass. (Fig. C.) A loose false bottom rests on
Walter Vincent Cuschieri
Authors: A. A Cuschieri
Journal: BMJ (2001)

John F Kennedy was rushed to the emergency room after being shot on Friday 22 November 1963.Crenshaw, a junior member of the team, did a cutdown on Kennedy's right leg to insert an intravenous line and watched others trying to save the president.Two days later, on Sunday 24 November 1963, Crenshaw was part of the team that tried to save Lee Harvey Oswald, thought to be the Kennedy assassin, after Oswald was shot by Jack Ruby.The Warren Commission investigating Kennedy's death did not call Crenshaw because Parkland officials did not want to publicise the role of residents in
Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge
Authors: Daphne A Stanley, Anna N Honko, Clement Asiedu, John C Trefry, Annie W Lau-Kilby, Joshua C Johnson, Lisa Hensley, Virginia Ammendola, Adele Abbate, Fabiana Grazioli, Kathryn E Foulds, Cheng Cheng, Lingshu Wang, Mitzi M Donaldson, Stefano Colloca, Antonella Folgori, Mario Roederer, Gary J Nabel, John Mascola, Alfredo Nicosia, Riccardo Cortese, Richard A Koup, Nancy J Sullivan
Journal: Nature Medicine (2014)