tbuckley/cabot-search huggingface dataset:
The Facial Palsies
Authors: Fred Harbert
Journal: JAMA (1981)

The authors of<i>The Facial Palsies</i>present a compendium of current knowledge and practice with a large bibliography and numerous figures. Fifteen of the 19 chapters are by J. Moldaver, who stresses electrodiagnostic tests. The large number of test figures may delight the technician, but have questionable relevance to the clinician. Moldaver advocates revival of intensity-duration curves (chronaxie) and less emphasis on conduction time and electromyography. Peripheral motor-unit tests are stressed over trunk stimulation of the facial nerve. A modified classification of nerve injuries is proposed, but Moldaver questions the ability to accurately localize and forecast prognosis because of pathology mixtures and bundle sparings. Bell's palsy is considered an acute nonprogressive condition, probably of viral etiology, which is not influenced by medical treatment or decompression. His warnings against slitting the epineurium and perineurium are corroborated by P. S. Spencer's histological findings. Scholarly discussions of anatomic and ethnic variations of mimetic
A mouse Fcγ-Fcε protein that inhibits mast cells through activation of FcγRIIB, SH2 domain–containing inositol phosphatase 1, and SH2 domain–containing protein tyrosine phosphatases
Authors: Elisabeth Mertsching, Lisa Bafetti, Henry Hess, Stuart Perper, Keith Giza, Lisa Chan Allen, Ella Negrou, Karen Hathaway, Jennifer Hopp, Julie Chung, Daniel Perret, Michael Shields, Andrew Saxon, Marilyn R. Kehry
Journal: Journal of Allergy and Clinical Immunology (2007)
Immediate and Late Clinical Outcomes of Carotid Artery Stenting in Patients With Symptomatic and Asymptomatic Carotid Artery Stenosis
Authors: Gary S. Roubin, Gishel New, Sriram S. Iyer, Jiri J. Vitek, Nadim Al-Mubarak, Ming W. Liu, Jay Yadav, Camilo Gomez, Richard E. Kuntz
Journal: Circulation (2001)

Carotid stenting is a less invasive percutaneous procedure than carotid endarterectomy for the treatment of carotid stenosis. Reports suggest that it can be performed with periprocedural complication rates similar to those of carotid endarterectomy. The purpose of this study was to determine short- and long-term outcomes in the largest prospective cohort of carotid stenting patients.This study followed 528 consecutive patients (604 hemispheres/arteries) undergoing carotid stenting. There was a 0.6% (n=3) fatal stroke rate and 1% (n=5) nonstroke death rate at 30 days. The major stroke rate was 1% (n=6), and the minor stroke rate was 4.8% (n=29). The overall 30-day stroke and death rate was 7.4% (n=43). Over the 5-year study period, the 30-day minor stroke rate improved from 7.1% (n=7) for the first year to 3.1% (n=5) for the fifth year (P:<0.05 for trend). The best predictor of 30-day stroke and death was age >/=80 years. After the 30-day period, the incidence of fatal and nonfatal stroke was 3.2% (n=31). On Kaplan-Meier analysis, the 3-year freedom from ipsilateral or fatal stroke was 92+/-1%.Experience from a single group of operators demonstrates that carotid stenting can be performed with an acceptable 30-day complication rate. Late follow-up also demonstrates a low rate of fatal and nonfatal stroke. These results suggest that carotid stenting may be comparable to carotid endarterectomy, and it underscores the clinical equipoise and premise for the National Institute of Health-supported, randomized Carotid Revascularization Endarterectomy Versus Stent Trial comparing carotid stenting with carotid endarterectomy.
Acute Intravascular Hemolysis and Acute Liver Failure Associated as a First Manifestation of Wilson's Disease
Authors: JACQUELINE ROCHE-SICOT
Journal: Annals of Internal Medicine (1977)

In three patients, the first manifestation of Wilson's disease was a syndrome in which acute intravascular hemolysis and acute liver failure were associated. This syndrome developed in three periods; the first, lasting 3 to 14 days, was characterized by fatigue, fever, and jaundice; the second, lasting 1 or 2 days, by severe acute intravascular hemolysis; and the third, lasting 2 to 6 days, by hepatic encephalopathy. All of the patients died from liver failure 7 to 21 days after the onset of the syndrome. The association of acute intravascular hemolysis and acute liver failure is a characteristic manifestation of Wilson's disease; it is rarely associated with other liver diseases. This association might result from hepatic cell necrosis due to accumulation of copper, the consequences being acute liver failure and destruction of erythrocytes by the large amounts of copper released from the necrotic hepatic cells to the plasma.
Severe and fatal anthracycline cardiotoxicity at cumulative doses below 400 mg/m<sup>2</sup>: Evidence for enhanced toxicity with multiagent chemotherapy
Authors: Raymond G. Watts
Journal: American Journal of Hematology (1991)

Three cases of severe, progressive, and in two cases, fetal cardiomyopathy secondary to anthracycline chemotherapy are reported. All of the patients were receiving multiagent chemotherapy for extremity sarcomas consisting of doxorubicin, high-dose methotrexate, bleomycin, cyclophosphamide, dactinomycin, and cisplatinum at the onset of their congestive heart failure. Cardiomyopathy developed in each patient at cumulative anthracycline doses less than 400 mg/m2. These cases suggest that enhanced cardiotoxicity may occur when anthracyclines are used in combination with other agents such as cyclophosphamide, bleomycin, cisplatinum, and methotrexate and that cumulative anthracycline doses considered to be "safe" may need to be lowered in these circumstances.
What Does the Duty to Warn Require?
Authors: Seema K. Shah, Sara Chandros Hull, Michael A. Spinner, Benjamin E. Berkman, Lauren A. Sanchez, Ruquyyah Abdul-Karim, Amy P. Hsu, Reginald Claypool, Steven M. Holland
Journal: The American Journal of Bioethics (2013)

"What Does the Duty to Warn Require?." The American Journal of Bioethics, 13(10), pp. 62–63 Acknowledgments This article is not subject to U.S. Copyright Law. This research was supported by the Intramural Research Program of the National Institutes of Health (NIH) in the Warren G. Magnuson Clinical Center. The opinions expressed are the view of the authors. They do not represent any position or policy of the U.S. National Institutes of Health, the Public Health Service, or the Department of Health and Human Services.
Plasma insulin, C-peptide, and glucagon levels in acute phase of ethanol-induced hypoglycaemia.
Authors: B I Joffe, R Shires, H C Seftel, L G Heding
Journal: BMJ (1977)

The possible association with bullous pemphigoid has not been reported.The occurrence of factor V inhibitors seems to have been associated with "autoimmune" disturbances in at least three of the 12 patients reported3-for example, penicillin allergy and the presence of autoantibodies such as antinuclear and rheumatoid factors.Antibodies to factor VIII have occurred in patients suffering from diseases with an autoimmune basis, such as asthma, rheumatoid arthritis, ulcerative colitis, and allergic reactions to penicillin.The association with pemphigoid may therefore suggest that the inhibitor may be a manifestation of some generalised autoimmune disturbance.
Rapid activation of the stat3 transcription complex in liver regeneration
Authors: Drew E. Cressman, Robert H. Diamond, Rebecca Taub
Journal: Hepatology (1995)

Liver regeneration in response to partial hepatectomy is a physiological growth response observed in the intact animal. Understanding the early signals that trigger liver regeneration is of vital importance to understand the liver's response to injury. It has been observed that several growth factors and cytokines, including epidermal growth factor (EGF) and interleukin-6 (IL-6), can activate members of the signal transducers and activators of transcription (Stat) family of transcription factors resulting in tyrosine phosphorylation of these factors, nuclear translocation, and an active DNA binding transcriptional complex. Because Stat3 participates in the regulation of primary growth response genes, we wondered if it is induced in the early phase of liver regeneration. We found that Stat3 DNA-binding activity is increased in the remnant liver within 30 minutes of partial hepatectomy and peaks at more than 30-fold at 3 hours. This induction is not observed after sham surgery. The induction of Stat3 appears to be part of the initial response of the remnant liver to partial hepatectomy, because it occurs in the presence of cycloheximide-mediated protein synthesis blockade. Activation of Stat3 is unusual, because it extends beyond the immediate-early time period and remains near peak level at 5 hours posthepatectomy. Although insulin-treated H35 cells activate many of the same immediate-early genes as regenerating liver, Stat3 is not induced in these cells. Because Stat factors are known to be inactivated by protein tyrosine phosphatases (PTPase), we showed that a PTPase is able to eliminate the DNA binding of hepatic Stat3.(ABSTRACT TRUNCATED AT 250 WORDS)
Erythema elevatum diutinum mimicking porphyria cutanea tarda
Authors: L. REQUENA, A. BARAT, A. HASSON, D. ARIAS, M.C. GUTIERREZ, L. MARTIN, A. CASTRO
Journal: British Journal of Dermatology (1991)

Journal Article Erythema elevatum diutinum mimicking porphyria cutanea tarda Get access L. REQUENA, L. REQUENA Department of Dermatology, Fundacion Jimenez Diaz, Clinica Nuestra Senora de la Conception, Universidad, Autonoma, Madrid, Spain Dr Luis Requena, C/Leopoldo Alas Clarin 4–6 °F. 28035 Madrid. Spain. Search for other works by this author on: Oxford Academic Google Scholar A. BARAT, A. BARAT Department of Pathology, Fundacion Jimenez Diaz, Clinica Nuestra Senora de la Conception, Universidad, Autonoma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar A. HASSON, A. HASSON Department of Dermatology, Fundacion Jimenez Diaz, Clinica Nuestra Senora de la Conception, Universidad, Autonoma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar D. ARIAS, D. ARIAS Department of Dermatology, Fundacion Jimenez Diaz, Clinica Nuestra Senora de la Conception, Universidad, Autonoma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar M.C. GUTIERREZ, M.C. GUTIERREZ Department of Dermatology, Fundacion Jimenez Diaz, Clinica Nuestra Senora de la Conception, Universidad, Autonoma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar L. MARTIN, L. MARTIN Department of Dermatology, Fundacion Jimenez Diaz, Clinica Nuestra Senora de la Conception, Universidad, Autonoma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar A. DE CASTRO A. DE CASTRO Department of Dermatology, Fundacion Jimenez Diaz, Clinica Nuestra Senora de la Conception, Universidad, Autonoma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 1, 1 January 1991, Pages 89–91, https://doi.org/10.1111/j.1365-2133.1991.tb03289.x Published: 01 January 1991
Chronic Sympathoexcitation through Loss of Vav3, a Rac1 Activator, Results in Divergent Effects on Metabolic Syndrome and Obesity Depending on Diet
Authors: Mauricio Menacho-Márquez, Rubén Nogueiras, Salvatore Fabbiano, Vincent Sauzeau, Omar Al-Massadi, Carlos Diéguez, Xosé R. Bustelo
Journal: Cell Metabolism (2013)

The role of the sympathetic nervous system, stress, and hypertension in metabolic syndrome and obesity remains unclear. To clarify this issue, we utilized genetically engineered mice showing chronic sympathoexcitation and hypertension due to lack of Vav3, a Rac1 activator. Here, we report that these animals develop metabolic syndrome under chow diet. However, they show protection from metabolic syndrome and obesity under fatty diets. These effects are elicited by α1-adrenergic- and diet-dependent metabolic changes in liver and the α1/β3 adrenergic-mediated stimulation of brown adipocyte thermogenesis. These responses seem to be engaged by the local action of noradrenaline in target tissues rather than by long-range effects of adrenaline. By contrast, they are not triggered by low parasympathetic drive or the hypertensive state present in Vav3-deficient mice. These results indicate that the sympathetic system plays divergent roles in the etiology of metabolic diseases depending on food regimen, sympathoexcitation source, and disease stage.
Hierarchies in Mental Hospitals
Authors: P. Sykes
Journal: BMJ (1964)

BmMHRIT 945 some real fresh air in the luxuriant grounds -even to go shopping in the nearby town.Old-fashioned visitors, bearing their pre- mortuary flowers, will be nonplussed to find their loved ones playing gin-rummy in the day-room instead of lying safely tucked up, wan and hush-voiced, in beds of sickness.Within less than a fortnight most patients will decide they are whole again, and will discharge themselves as fit to get on with the business of living.There will be no need, moreover, for expensive convalescent and rehabilitation units, except for those comparatively rare cases left with some per- manent disability which has to be circum- vented.Illnesses, operations, physicians, and surgeons (it may be regretted) will have lost their mystique, their prestige, and their glamour.A stay in hospital will have come to be regarded as a slightly discreditable inci- dent, like a visit to the dentist, instead of- as now-a sacred ritual comparable to the lengthy Arapesh initiation ceremony.'Mind you, there is another school of thought which predicts that by A.D. 2014 a dental extraction will involve 14 days' bed- rest in a vitiated sleepless atmosphere, two weeks' convalescence, six weeks' sick benefit, and, of course, out-patient follow-up for six months.This may be true: indeed, such may be the present trend; but my bet is that in a further 50 years the pendulum will have swung the other way.My way.Any takers ?-I am, etc.,
Radiology for psychiatric patients
Authors: M J Thomas, R Srivastav, A V Bhide, K Nandini
Journal: BMJ (1986)

lithotripsy debate once again reinforces the truth that we do not.Patients in this country are being treated with methods now outmoded in com- parable Westernised societies-for example, the large number of open prostatectomies still being performed by general surgeons' while patients in the rest of the world are treated with less traumatic and sophisticated transurethral resection.We currently have the lowest rate of lithotripsy per head in the West apart from Egypt.The Department of Health 4nd Social Security-was informed five years ago that lithotripsy would become a principal technique for treating renal stones, and it is the DHSS that has inhibited our patients from benefiting-from this highly effective and atraumatic procedure.The controlled trial is a heaven sent opportunity to avoid making a commitment.We are hardly determining here whether a pink pill is slightly better than a green one: the
Public Policy Governing Organ and Tissue Procurement
Authors: Aaron Spital
Journal: Annals of Internal Medicine (1996)

Letters1 February 1996Public Policy Governing Organ and Tissue ProcurementAaron Spital, MDAaron Spital, MDThe Gennessee Hospital; Rochester, NY 14607Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-3-199602010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent study, Siminoff and colleagues [1] found that despite widespread public support for organ and tissue donation, family refusal was “the major impediment to procurement.” This important observation confirms previous suggestions that the need to obtain family approval represents a major barrier to the donation process [2, 3]. It is therefore unfortunate that, in contrast to the authors' assertion, our approach to organ and tissue procurement has emphasized the family, rather than the individual person. Although the Uniform Anatomical Gift Act does give adults legal authority to make binding decisions for themselves regarding donation, public ...References1. Siminoff LA, Arnold RM, Caplan AL, Virnig BA, Seltzer DL. Public policy governing organ and tissue procurement in the United States. Results from the National Organ and Tissue Procurement Study. Ann Intern Med. 1995; 123:10-7. Google Scholar2. Spital A. Consent for organ donation: time for a change. Clin Transpl. 1993; 7:525-8. Google Scholar3. Spital A. Mandated choice: a plan to increase public commitment to organ donation. JAMA. 1995; 273:504-6. Google Scholar4. Hessing DJ, Elffers H. Attitude toward death, fear of being declared dead too soon, and donation of organs after death. OMEGA. 1986-87:17:115-26. Google Scholar5. “Texas State Legislature House Bill 271; 1991.” Google Scholar Author, Article, and Disclosure InformationAuthors: Aaron Spital, MDAffiliations: The Gennessee Hospital; Rochester, NY 14607 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1996Volume 124, Issue 3Page: 374KeywordsAdultsFearPilot studiesPublic policy ePublished: 15 August 2000 Issue Published: 1 February 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cloning and the U.S. Congress
Authors: George J Annas
Journal: New England Journal of Medicine (2002)

Legislation is pending in the Congress that could affect research using embryonic stem cells. In a Legal Issues in Medicine article, Annas outlines the bill passed by the House of Representatives, the bills pending in the Senate, and the position of the current administration on these issues. In his opinion, the issue of reproductive cloning must be considered separately from issues related to therapeutic cloning if any real progress is to be made. The controversy surrounding the scientific and medical use of stem cells is further explored in two Sounding Board articles by Weissman and Evers. Weissman discusses the situation in the United States, and Evers presents the European perspective.
Experimental toxicology of pyrolysis and combustion hazards.
Authors: H H Cornish, K J Hahn, M L Barth
Journal: Environmental Health Perspectives (1975)

Data are presented on the acute toxicity (mortality only) of the thermal degradation products of polymers obtained by two methods of degradation. One system utilized a slowly increasing temperature (5 degrees C/min) and gradual degradation of the polymer with the rats being exposed to degradation products as they were evolved. In this system the more toxic polymers included wool, polypropylene, poly(vinyl chloride), and urethane foam. The second system utilized conditions of rapid combustion and exposure of rats to the total products of combustion for a period of 4 hr. In this system the more toxic materials included red oak, cotton, acrylonitrile-butadiene-styrene (ABS), and styrene-acrylonitrile. It is of interest to note that the natural product wool is among the least toxic under these rapid combustion conditions and among the most toxic under slow pyrolysis conditions. Other materials also vary in the comparative toxicity of their thermal degradation products, depending upon the conditions of degradation and animal exposure. The two experimental techniques presented here may well represent the two extreme conditions of rapid combustion versus slow pyrolysis. Intermediate types of fire situations might be expected to result in relative acute toxicities somewhere between these two extremes. This report deals with acute toxicity on the basis of mortality data only and does not include other parameters of toxicity such as organ weights and histopathology.
Caffeine for Apnea of Prematurity
Authors: Eduardo Bancalari
Journal: New England Journal of Medicine (2006)

Caffeine is one of the most commonly prescribed drugs among premature infants. It is a potent respiratory stimulant indicated primarily to reduce the incidence of episodes of apnea associated with an immature central nervous system. It is also used frequently in these infants to facilitate weaning from mechanical ventilation. Despite the widespread use of caffeine for these indications, the evidence to support its use is based on the results of a few relatively small and short-term studies.1 Information is lacking on possible long-term effects of prolonged administration of caffeine on the development of the brain and other organs.In this . . .
USE OF DIPHTHERIA ANTITOXIN IN THE TREATMENT AND PREVENTION OF DIPHTHERIA.
Authors: WILLIAM H. PARK
Journal: JAMA (1900)

The final test of the value of diphtheria antitoxin in diphtheria is the results derived from its use. The difficulty, however, of knowing what would have been the course of a case, if antitoxin had not been used or had been used, is so great that it is well to gather proofs from other possible sources, as well as from personal experience. Therefore, I will consider certain facts derived from laboratory experience and from statistics. Is the diphtheria bacillus capable of growing in the human throat and there producing poisons, which when absorbed and brought in contact with the cells of the body excite processes which we call diphtheria? The truth of this is established. Personally I know of three instances in which the virulent bacillus we use in our laboratory was sucked into the mouth by mistake. In two severe diphtheria developed within sixty hours, and in the third