Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women
Authors: Tom A. Elasy, Matthew J. Levinsky
Journal: Annals of Internal Medicine (2000)

Letters1 February 2000Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly WomenTom A. Elasy, MD, MPH and Matthew J. Levinsky, MDTom A. Elasy, MD, MPHVanderbilt University Medical Center; Nashville, TN 37232 (Elasy)Vanderbilt University Medical Center; Nashville, TN 37232 (Levinsky)Search for more papers by this author and Matthew J. Levinsky, MDVanderbilt University Medical Center; Nashville, TN 37232 (Elasy)Vanderbilt University Medical Center; Nashville, TN 37232 (Levinsky)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-3-200002010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Recker and colleagues (1) add to the body of knowledge on the bone-sparing efficacy and tolerability of low-dose estrogen and progesterone. We have two substantial concerns about aspects of the analysis and presentation of the data that detract from an otherwise well-done study. Figure 2 compares changes in the treatment and placebo groups. By presenting only one standard error of the mean with the effect measure, a reader may be led to believe that the differences are statistically significant. That is not the case. The authors have effectively presented a 68% confidence interval. Although we do not ...References1. Recker RR, Davies KM, Dowd RM, Heaney RP. The effect of low-dose continuous estrogen and progesterone therapy with calcium and vitamin D on bone in elderly women. A randomized, controlled trial. Ann Intern Med. 1999;130:897-904. LinkGoogle Scholar2. Lang TA, Secic M. How To Report Statistics in Medicine. Annotated Guidelines for Authors, Editors, and Reviewers. Philadelphia: American Coll of Physicians; 1997:63. Google Scholar Author, Article, and Disclosure InformationAffiliations: Vanderbilt University Medical Center; Nashville, TN 37232 (Elasy)Vanderbilt University Medical Center; Nashville, TN 37232 (Levinsky) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Robert R. Recker , K. Michael Davies , Rachel M. Dowd , and Robert P. Heaney Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Jeffrey Brian Barnes and David T. Bess Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Robert R. Recker , Robert P. Heaney , and K. Michael Davies Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Francisco R. Lafita and Belinda Garcia Metrics 1 February 2000Volume 132, Issue 3Page: 244KeywordsBone densityCalciumConfidence intervalsElderlyEstrogensHormone replacement therapyProgesteroneStandard error of the meanStatistical dataVitamin D ePublished: 15 August 2000 Issue Published: 1 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...