tbuckley/cabot-search huggingface dataset:
1036 Pretransplant meld score and posttransplant survival in adult patients undergoing live donor liver transplantation
Authors: Z KARASU, M AKYILDIZ, M KILIC, Y YUZER, U AKARCA, Y TOKAT, A CELEBI, G ERSOZ, Y BATUR, F GUNSAR
Journal: Hepatology (2003)

With the extensive use of living donor liver grafts in adult patients, controversy over small-for-size syndrome has escalated in recent years. Although several symptoms have been suggested as manifestations of the syndrome, small-for-size syndrome remains difficult to diagnose because these symptoms are neither specific nor inevitable. The occurrence of small-for-size syndrome also seems to depend on a number of recipient and graft factors. Potential pathogenic mechanisms include persistent portal hypertension and portal overperfusion. At present, several techniques are being explored in an attempt to ameliorate the impact of small-for-size syndrome. Recent experience suggests that the occurrence of small-for-size syndrome is multifactorial and that complications relating to small-for-size grafts should be examined in relation to a variety of graft, recipient, and technical factors. (Liver Transpl 2003;9:S29-S35.)
Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection
Authors: Jamie F.S. Mann, Paul F. McKay, Samantha Arokiasamy, Reeyeshkumar K. Patel, Katja Klein, Robin J. Shattock
Journal: Journal of Controlled Release (2013)

Vaccination through mucosal surfaces has been shown to elicit antiviral immune responses against a number of mucosal pathogens. Here we demonstrate that both mucosal and systemic immune responses can be elicited against a model HIV-1 CN54gp140 antigen when cation-complexed plasmid DNA vaccines are applied topically to the murine pulmonary mucosa as an immune priming strategy. Furthermore, using an influenza challenge model we show that a plasmid DNA vaccine complexed to a less toxic form of PEI called dPEI (a nearly fully hydrolysed linear PEI with 11% additional free protonatable nitrogen atoms) can provide significant protection against a respiratory challenge infection in mice. Furthermore, we show that dPEI polyplexes have the potential to transfect not only mucosal epithelium, but also to enter deeper into tissues through the modulation of tight junction integrity. Taken together, these results demonstrate that less toxic forms of PEI can be effective delivery vehicles for plasmid DNAs to elicit cellular and humoral protective responses in vivo. Moreover, our observations suggest that these less toxic derivatives of PEI could be utilised for topical plasmid DNA vaccine delivery to human mucosal tissue surfaces, and that this application may permit dissemination of the immune responses through the linked mucosal network thus providing protective immunity at distal portals of pathogen entry.
Clinical Utility of In-111 Leukocyte Imaging in Crohnʼs Disease
Authors: FARHAD NAVAB, CHARLES M. BOYD
Journal: Clinical Nuclear Medicine (1995)

Thirty six patients with Crohn's disease were studied with in-111 leukocyte imaging. There was a correlation of the presence of activity on early (4 hour) imaging (r=0.516, P < 0.001) and on delayed 18-24 hour) imaging (r=0.457, P < 0.003). In the total group of 36 patients, the results of imaging were useful in the immediate management of 13 patients (36.1%). These included four patients (11.1%) who refused to undergo colonoscopic examination and nine patients (25%), six of whom had previous intestinal resection.
α-Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration
Authors: Amanda E. Boggs, Michele I. Vitolo, Rebecca A. Whipple, Monica S. Charpentier, Olga G. Goloubeva, Olga B. Ioffe, Kimberly C. Tuttle, Jana Slovic, Yiling Lu, Gordon B. Mills, Stuart S. Martin
Journal: Cancer Research (2014)

Abstract Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic strategies that remain wanting. In this study, we report that elevated levels of α-tubulin acetylation are a sufficient cause of metastatic potential in breast cancer. In suspended cell culture conditions, metastatic breast cancer cells exhibited high α-tubulin acetylation levels that extended along microtentacle (McTN) protrusions. Mutation of the acetylation site on α-tubulin and enzymatic modulation of this posttranslational modification exerted a significant impact on McTN frequency and the reattachment of suspended tumor cells. Reducing α-tubulin acetylation significantly inhibited migration but did not affect proliferation. In an analysis of more than 140 matched primary and metastatic tumors from patients, we found that acetylation was maintained and in many cases increased in lymph node metastases compared with primary tumors. Proteomic analysis of an independent cohort of more than 390 patient specimens further documented the relationship between increased α-tubulin acetylation and the aggressive behaviors of basal-like breast cancers, with a trend toward increased risk of disease progression and death in patients with high-intensity α-tubulin acetylation in primary tumors. Taken together, our results identify a tight correlation between acetylated α-tubulin levels and aggressive metastatic behavior in breast cancer, with potential implications for the definition of a simple prognostic biomarker in patients with breast cancer. Cancer Res; 75(1); 203–15. ©2014 AACR.
P3-047: NSCLC: Primary tumor size – radiation dose related accelerated, twice daily radiotherapy by target splitting, preceded by 2 cycles of chemotherapy: First results of a prospective study
Authors: Karl Wurstbauer, Heinz Deutschmann, Peter Kopp, Florian Merz, Manfred Kranzinger, Olaf Nairz, Michael Studnicka, Felix Sedlmayer
Journal: Journal of Thoracic Oncology (2007)
General Medical Council launches fresh inquiry into pathologist in G20 protest case
Authors: C. Dyer
Journal: BMJ (2011)

Acetylmethylcarbinol (acetoin) formed during yeast fermentations of sugar reaches a maximum of about 25 to 100 ppm about midway through fermentation, and then largely disappears, presumably by reduction to 2,3-butanediol. The peak of acetoin content coincided with the maximum level of acetaldehyde formation, which follows a similar pattern of rise and decline. The acetoin content of sweet (dessert) wines produced by the addition of wine spirits to half fermentation was much higher (50 to 200 ppm) than corresponding dry wines produced by complete fermentation (about 5 to 20 ppm). Significantly higher levels of acetoin (up to 350 ppm) were found in sherry samples produced by the submerged flor yeast fermentation than in those of comparable baked-type sherry. However, diacetyl was not higher (less than 1 ppm) as a result of the oxidative conditions of the submerged flor process. The creatine-αnaphthol colorimetric method was used for acetoin for measurement, but it gave erroneously high values for diacetyl in the presence of acetoin, so diacetyl was determined by a colorimetric nickel dimethylglyoxime method. The possible significance of acetoinic compounds in wines is discussed.
Central nervous system and ophthalmic involvement in nephropathia epidemica (European type of haemorrhagic fever with renal syndrome)
Authors: C. Ahlm, C. Lindén, M. Linderholm, O.A. Alexeyev, J. Billheden, F. Elgh, M. Fagerlund, B. Zetterlund, B. Settergren
Journal: Journal of Infection (1998)
Response to Letter Regarding Article, “A Sensitive Dissection: Profound Bradycardia Complicating Carotid Dissection”
Authors: Daisy Dulay, Paul A. Gould, Andrew D. Krahn, Andrew Leung
Journal: Circulation (2009)

Profound Bradycardia Complicating Carotid Dissection"We thank Dr Sarikaya and colleagues for their response to our image and case report on carotid dissection and profound bradycardia, and we welcome diversity of interpretation of the underlying mechanism of the observations. 1The profound progressive bradycardia observed was reminiscent of reflex bradycardia seen most often in vasovagal syncope and carotid sinus sensitivity.The patient's history of vasovagal syncope in combination with local injury to the carotid bulb region lead us to conclude that the most likely explanation for the profound and recurrent bradycardia was a local one, but this is by no means either conclusive or exclusive.We were unable to perform carotid sinus massage in this case, which may have strengthened the mechanistic association.The insult in this case involves dissection between intima and media with hemorrhage into the arterial wall where the carotid receptors reside, with secondary thrombosis and occlusion.The very transient nature of the bradycardia suggested a brief reflex response and not an ongoing central mechanism influencing heart rate and blood pressure control, though this cannot be excluded.Clearly the insula is important in the "brain-heart" interaction and may have played a role in this case. 2ith respect to the assertion by Dr Sarikaya and colleagues that they have not observed this in 136 patients, failing to observe this by no means excludes carotid hypersensitivity, given that "absence of proof is not proof of absence."Mokri et al described syncope in 1 of 36 patients with carotid dissection, which would have been our case had the patient not presented an hour later. 3Individuals with carotid-related tumors are also well known to present with syncope and bradycardia, though they are thankfully rare. 4Furthermore, syncope in conjunction with stroke is well described, 5 and cardiac monitoring is not necessarily in place early in the course of stroke to correlate with.As indicated in our discussion, the mechanism of bradycardia may have been a "carotid sinus hypersensitivity variant, and insular mediated arrhythmia after stroke."Analogous to the incomplete understanding of the mechanism underlying vasovagal syncope, it is likely that the final explanation is both complex and multifactorial.
BMA's chairman calls on Labour to face the facts
Authors: L. Beecham
Journal: BMJ (1998)

The chairman of the BMA's council has called on the government to “face the facts.”

Giving his last address as council chairman to the annual representative meeting in Cardiff this week, Sir Alexander Macara said that the government had accepted GPs' concerns about the headlong implementation of primary care groups. It needed to face the fact that hospital specialists and public health doctors had a crucial …
[718] HEPATIC MANIFESTATION OF METABOLIC SYNDROME (MS): NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND SERUM ADIPOKINES
Authors: M. Jarrar, B. Ranard, M. Stepanova, C. Nugent, H. Elariny, C. Bennett, R. Collantes, Z. Goodman, V. Chandhoke, A. Baranova, Z. Younossi
Journal: Journal of Hepatology (2007)
Integrin-linked kinase: both Jekyll and Hyde in rhabdomyosarcoma
Authors: Paul C. McDonald, Shoukat Dedhar, Charles Keller
Journal: Journal of Clinical Investigation (2009)

Although the molecular differences between embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) have been extensively interrogated, effective therapies tailored to a particular rhabdomyosarcoma subtype have yet to emerge. Patients with ERMS have shown incremental improvement using current multimodal therapy, but survival rates for metastatic ARMS remain poor. In this issue of the JCI, Durbin and colleagues demonstrate that integrin-linked kinase (ILK) acts as a tumor suppressor in ERMS and as a proto-oncogene in ARMS, and that the opposing functions of this enzyme are dependent on the JNK1 signaling pathway (see the related article beginning on page 1558). Their findings suggest that targeting ILK may represent a focused therapeutic strategy for the treatment of ARMS.
Bitter lemon purpura.
Authors: J A Murray, I Abbott, D A Anderson, A D Morgan
Journal: BMJ (1979)

the genesis of pruritus ani.Faeces contain bacteria whose metabolic products include endopeptidases, which can produce itching in experimental conditions.5 6Although dysfunction of the anal sphincter itself may not be the cause of pruritus ani, it may be an important contributing factor.Further studies are required ofthe action of the sphincters in this condition, together with studies of the faecal and perianal skin flora.Nevertheless, the results reported here suggest an important new approach that may help to elucidate this trouble- some ailment.
Early amniocentesis: a cytogenic evaluation.
Authors: T. W. Meade, A. M. Grant
Journal: BMJ (1989)

recruitment restricts the sample to members of peer groups and hence does not give a true picture of the range of workers (and presumably risks) involved in the sex industrv.This method may unintentionallv introduce bias into the results by increasing group awareness of the existence and aims of the study.We believe that a combination of recruitment tactics generates a more representative sample of the heterogeneous population of male prostitutes.
Pleasant memories: remembering immune protection while forgetting about graft-versus-host disease
Authors: Paul M. Sondel, Ilia N. Buhtoiarov, Kenneth DeSantes
Journal: Journal of Clinical Investigation (2003)

Graft-versus-host disease (GVHD) represents a major cause of morbidity and mortality following conventional allogeneic hematopoietic stem cell transplantation (HSCT). A study in mice (see related article on pages 101–108) demonstrates that the selective administration of donor memory CD4+ T cells results in immune reconstitution without GVHD, a result that, if translatable to humans, has important clinical implications for HSCT.
Vascular Endothelial Growth Factor-Delivery Systems for Cardiac Repair: An Overview
Authors: Teresa Simón-Yarza, Fabio R. Formiga, Esther Tamayo, Beatriz Pelacho, Felipe Prosper, María J. Blanco-Prieto
Journal: Theranostics (2012)

Since the discovery of the Vascular Endothelial Growth Factor (VEGF) and its leading role in the angiogenic process, this has been seen as a promising molecule for promoting neovascularization in the infarcted heart. However, even though several clinical trials were initiated, no therapeutic effects were observed, due in part to the short half life of this factor when administered directly to the tissue. In this context, drug delivery systems appear to offer a promising strategy to overcome limitations in clinical trials of VEGF.The aim of this paper is to review the principal drug delivery systems that have been developed to administer VEGF in cardiovascular disease. Studies published in the last 5 years are reviewed and the main features of these systems are explained. The tissue engineering concept is introduced as a therapeutic alternative that holds promise for the near future.
Post-operative Hypoxaemia and Oxygen Therapy
Authors: C. M. Conway, J. P. Payne
Journal: BMJ (1963)

During preliminary experiments carried out on post- operative patients to study the efficiency of the Oxygenaire disposable oxygen mask it was observed that the control blood samples were desaturated.It was planned, therefore, to investigate not only the efficiency of the mask but also the incidence and extent of the oxygen desaturation and the effect of oxygen administration.
Histiocytosis X: Response to Vinblastine Sulfate
Authors: Jerome S. Siegel
Journal: JAMA (1966)

The designation histiocytosis X was coined as a unifying diagnostic term by Lichtenstein to draw attention to the pathological unity made up of several diverse and transitional syndromes, ie, eosinophilic xanthomatous granuloma, Hand-Schüller-Christian syndrome and Letterer-Siwe disease. Lichtenstein preferred the terms localized, chronic disseminated, and acute disseminated histiocytosis X to represent these related entities. A 40-year-old white man presented with localized histiocytosis X which progressed to a chronic disseminated form of the disease that could not be distinguished from Hand-Schüller-Christian disease. Almost complete resolution of this very resistant tumor occurred following treatment with vinblastine sulfate.
Abstract 2246: Senescence as a result of impaired ribosome biogenesis
Authors: Frédéric Lessard, Véronique Bourdeau, Xavier Deschênes-Simard, Sebastian Igelmann, Marinieve Montero, Gerardo Ferbeyre
Journal: Cancer Research (2014)

Abstract Senescence is a stable arrest of cell proliferation in which the cells remain viable and metabolically active but display a constitutive activation of the DNA damage response and of the tumor suppressors p53 and RB. The senescent phenotype can be induced by multiple stresses including short telomeres and oncogenes. We have shown that senescence, involves the ERK-dependent degradation of selective proteins involved in cell cycle progression and tumorigenesis. We call this process senescence associated protein degradation (SAPD) and it involves many nucleolar proteins that play a role in ribosome biogenesis. Using tritium pulse labelling we found a strong decrease of rRNA synthesis in senescent cells indicating that the degradation of nucleolar proteins is functionally relevant. Because we know how exactly the human 47S precursor rRNA is processed, it was possible to design primers on both sides of some processing sites and study their maturation by QPCR. In this way we showed defects in the processing of rRNA in senescent cells. Knocking down some of the nucleolar proteins degraded in senescence was sufficient to trigger the process indicating that a decrease in ribosome biogenesis is causal to cellular senescence. Mechanistically, the degradation of nucleolar proteins during senescence involves the ubiquitin-proteasome system suggesting that E3 ligases link the oncogenic stress that trigger senescence to nucleolar proteins degradation. We will discuss ongoing efforts to identify these enzymes. Citation Format: Frédéric Lessard, Véronique Bourdeau, Xavier Deschênes-Simard, Sebastian Igelmann, Marinieve Montero, Gerardo Ferbeyre. Senescence as a result of impaired ribosome biogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2246. doi:10.1158/1538-7445.AM2014-2246
He Lectures on Grace
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2010)

Ad Libitum16 November 2010He Lectures on GraceJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom Setauket, NY 11733.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-10-201011160-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The first setback to his talkon grace was the lackof sync between his laptopand their projector.An electronic screechpierced the room, but whenat last they found a manto fix the sound, it lesseneda little. And the glitchin his introductionby a ponderous former dean,who mistakenly called hima family doctor fromMissouri, while holdingthe podium up with burstsof hot gas, and then leftfor his important meetingbefore the talk—that couldhave been worse. And the lunch,a catered spread of salads,sandwiches, schmoozing,and lack of attention, didn'tactually prevent himfrom speaking. Faces arose,faces fell, the clatterresumed. How he relishedthis lesson in detachment!And began, Courage, saidErnest Hemingwayis grace under pressure.... Author, Article, and Disclosure InformationAffiliations: From Setauket, NY 11733.Current Author Address: Jack Coulehan, MD, MPH, 4 Townsend Court, Setauket, NY 11733. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 November 2010Volume 153, Issue 10Page: 692 ePublished: 16 November 2010 Issue Published: 16 November 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Tracheal botryomycosis in a patient with tracheopathia osteochondroplastica
Authors: J. Y. Shih, P. R. Hsueh, Y. L. Chang, L. N. Lee, Y. C. Chen, M. F. Chen, K. T. Luh
Journal: Thorax (1998)

Tracheal botryomycosis has never been reported in the literature. A 68 year old man presented with progressive dyspnoea and an exophytic mass below the vocal cords was found by bronchoscopy. Pathological study of the mass showed tracheal botryomycosis probably associated with Peptostreptococcus spp infection. The patient was given intravenous penicillin for six weeks. Tracheal obstruction necessitated tracheal resection and the surgical specimen revealed typical findings of tracheopathia osteochondroplastica without residual lesions of botryomycosis.
Rheumatoid heart disease.
Authors: J Kirk, J Cosh
Journal: Annals of the Rheumatic Diseases (1969)

factor, LDH cells, and protein were investigated.The clinical evaluation and temperature measurements were performed before treatment and on five occasions during the 6-week follow-up, laboratory estimations being done at the beginning and end of the trial.From the above investigations we concluded that there was no difference in the temperature curves in either group and this was confirmed statistically.Pain improved to a statistically significant degree in both groups.Joint mobility-measured in terms of knee flexions per 30 sec.-showed a statistically significant improvement at all follow-up stages in the lavage patients but not in the controls; testing between the two groups showed no significant difference.Similarly, as regards the range of
FEDERAL CONTROL OVER THE MANUFACTURE OF SERUMS AND VACCINES
Authors: JOHN F. ANDERSON
Journal: JAMA (1913)

country generally-a campaign that applies to the public, but 1 do not see that it applies much to tbe ollicials or others running corporations.If this safety campaign is needed, it should reach the ollîciiils of the railways and be taken up in the surgical associations of the different companies.Dr. Lawrence B. Pilshury, Lincoln, Neb.:Some time ago there was brought to the Nebraska Hospital for the insane a young man of about 30 who hud been employed by u In ige railway system to operate a switch-tower at a junction in one of the smaller towns of the state.The management of this road is a careful one and few disasters occur, but this man hud been working so recently that his last pay-check was sent to him after he bud been committed to the hospital.This young man bud evidently not attracted attention.The only obvious physical sign he showed was foot-drop caused by injury of the muscles of the foot in childhood, a defect which had never been repaired, The man was apparently and unquestionably a paretic, and that be should hnvc been in charge personally of signals and switches, alone in tbe tower, was obviously preposterous.Dn. ClIABLES Gorst, Mendotn, Wis.: No position connected with a railway is more important to the public than that of the man who runs a locomotive on a passenger train. 1 believe that a man's personal liberty should not be consid- ered when be is incompetent to till so important n place.My experience of nine yours in the position I now bold, that
Pancreatic Cancer
Authors: Erin Brender
Journal: JAMA (2005)

Pancreatic CancerT he pancreas is a gland that lies deep in the abdomen behind the stomach, near the intestines, and on top of the spine.It is responsible for producing juices that help digest food and for making hormones such as insulin (regulates blood sugar levels).Pancreatic cancer (cancer of the pancreas) can develop in certain individuals and is a serious disease, being the fourth leading cause of cancer-related deaths in the United States.The December 14, 2005, issue of JAMA includes an article about pancreatic cancer in smokers.
Fibrinolysis and Toxaemia of Pregnancy
Authors: E. N. Wardle
Journal: BMJ (1970)

than to take intermittent courses".However, it is also important that all women should be carefully instructed not to miss a tablet and what to do in such an event.Verton is clearly not indicated for those in whom pregnancy is absolutely contraindicated.However, it is useful for those spacing their families for whom an unexpected pregnancy would not be a disaster.-Iam, etc.,