tbuckley/cabot-search huggingface dataset:
NEW ROENTGENOGRAPHIC TECHNIQUE IN BRONCHIAL ASTHMA
Authors: C. Jiménez Díaz
Journal: JAMA (1952)

During the past two years, we have been utilizing a technique of making roentgenographs of the chest in asthmatic persons that has given us considerable information concerning the pulmonary function of the patient. In this report we wish to present this method and to elaborate on some of the results obtained from it. <h3>TECHNIQUE AND RESULTS</h3> The first roentgenograph is taken during forced inspiration. Immediately after, a second roentgenograph is taken in deep expiration, the patient remaining in exactly the same position. The roentgenographs are then superimposed one on the other and studied comparatively. In placing the second film upon the first, the spinal column, especially the first dorsal vertebra, serves as a guide; the outline of the vertebral body and of the transverse processes can be clearly distinguished. Once they have been correctly superimposed, the changes of the diaphragm, ribs, and clavicles occurring during expiration are sketched on the
SIX-MONTH CLINICAL OUTCOMES AFTER BELOW-THE-KNEE ANGIOPLASTY FOR CRITICAL LIMB ISCHEMIA IN PATIENTS ON HEMODIALYSIS
Authors: Nakano Masatsugu, Toshiya Muramatsu, Reiko Tsukahara, Keisuke Hirano, Yoshiaki Itou, Hiroshi Ishimori, Masahiro Yamawaki, Motoharu Araki, Yasunari Sakamoto, Shinya Sasaki, Ittuki Komatsu
Journal: Journal of the American College of Cardiology (2010)
Erythropoietin for Total Hip Joint Arthroplasty
Authors: Brian G. Feagan
Journal: Annals of Internal Medicine (2001)

Letters18 September 2001Erythropoietin for Total Hip Joint ArthroplastyBrian G. Feagan, MDBrian G. Feagan, MDUniversity of Western Ontario; London Clinical Trials Research Group; London, Ontario N6A 5K8, CanadaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-6-200109180-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our study of transfusion practice reflected the “real world” management by surgeons of patients with total hip joint arthroplasty. This approach is more relevant than the alternative, suggested by Dr. Kontor, of imposing arbitrary, non–evidence-based strict transfusion criteria. Most participants (64%) in the second Canadian Orthopedic Perioperative Erythropoietin Study (COPES II) who received transfusion had a hemoglobin concentration less than 80 g/L. Most clinicians accept that treatment or prevention of this degree of anemia in elderly patients undergoing total hip joint arthroplasty is desirable.While we acknowledge that little evidence exists to support the notion that transfusion improves ...References1. Carson JL, Duff A, Berlin JA, Lawrence VA, Poses RM, Huber EC, et al . Perioperative blood transfusion and postoperative mortality. JAMA. 1998;279:199-205. [PMID: 9438739] CrossrefMedlineGoogle Scholar2. Zuccalà G, Bernabei R, Carbonin P. Perioperative blood transfusion [Letter]. JAMA. 1998;279:1610-2. [PMID: 9613903] CrossrefMedlineGoogle Scholar3. Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, et al . A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340:409-17. [PMID: 9971864] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Western Ontario; London Clinical Trials Research Group; London, Ontario N6A 5K8, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 September 2001Volume 135, Issue 6Page: 471KeywordsAnemiaAttentionBlood transfusionDeath ratesErythropoietinHemoglobinHip fracturesMortalitySurgeonsTotal hip arthroplasty ePublished: 18 September 2001 Issue Published: 18 September 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Visualization of Ebstein's anomaly of the tricuspid valve by two-dimensional and standard echocardiography.
Authors: M Matsumoto, H Matsuo, S Nagata, Y Hamanaka, T Fujita
Journal: Circulation (1976)

Seven patients with Ebstein's anomaly were studied by two-dimensional echocardiography, with and without stop-action technique, and by standard echocardiography. Sagittal two-dimensional echocardiograms visualized a small functional right ventricle and a large atrialized right ventricle. These two parts of the chamber were separated by the anterior tricuspid leaflet and its chordae tendineae. The echocardiograms corresponded to the findings of the right ventriculogram. In horizontal two-dimensional echocardiograms a huge anterior tricuspid leaflet, atrialized right ventricle, and a displaced septal tricuspid leaflet, intervening between the functional right ventricle and the sinus portion of the functional right ventricle, were visualized. The origin of the septal tricuspid leaflet was clearly shown to be abnormal in five cases. The left ventricle was small with distinct clockwise rotation of the interventricular septum. Two-dimensional echocardiography provided information useful in evaluation of the functions of the right ventricle and the tricuspid valve and determination of what surgical procedure to follow.
Lichenoid tattoo reactions
Authors: Jacqueline Clarke, Martin M. Black
Journal: British Journal of Dermatology (1979)

Journal Article Lichenoid tattoo reactions Get access JACQUELINE CLARKE, JACQUELINE CLARKE Department of Dermatology, St Thomas' Hospital, London SE1 7EH Search for other works by this author on: Oxford Academic Google Scholar MARTIN M. BLACK MARTIN M. BLACK Department of Dermatology, St Thomas' Hospital, London SE1 7EH Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 100, Issue 4, 1 April 1979, Pages 451–455, https://doi.org/10.1111/j.1365-2133.1979.tb01649.x Published: 01 April 1979
Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium
Authors: Audrey Rakian, Wu-Chen Yang, Jelica Gluhak-Heinrich, Yong Cui, Marie A Harris, Demitri Villarreal, Jerry Q Feng, Mary MacDougall, Stephen E Harris
Journal: International Journal of Oral Science (2013)

Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP. Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP. These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. An important protein involved in tooth development also plays a critical role in the formation of the surrounding dental tissues and the tooth-root. To investigate the role of bone morphogenetic protein 2 (BMP2) in the development of structures that support teeth, a team led by Stephen Harris at the University of Texas Health Science Center at San Antonio, USA, deleted the Bmp2 gene in a mouse model. They observed major defects in tooth-root formation, as well as in the establishment of cementum, periodontal ligament and alveolar bone — all part of supporting structures that surround tooth-roots. BMP2 is also involved in the proper development of teeth themselves. As such, the findings shed light on one key developmental pathway shared by cells across the dental tissue spectrum.
Effects of surgical operation and bed rest on cardiovascular responses to exercise in hospital patients
Authors: E. J. BASSEY, T. BENNETT, A. T. BIRMINGHAM, P. H. FENTEM, D. FITTON, R. GOLDSMITH
Journal: Cardiovascular Research (1973)

Male hospital patients were examined for changes in the responses to exercise after operation and bed rest of different durations. One of the changes observed was an enhanced increase in heart rate during exercise; this could be reversed by ambulation or physiotherapy.
Oral lichen planus: an immunoperoxidase study using monoclonal antibodies to lymphocyte subsets
Authors: J. B. MATTHEWS, C. M. SCULLY, A. J. C. POTTS
Journal: British Journal of Dermatology (1984)

Journal Article Oral lichen planus: an immunoperoxidase study using monoclonal antibodies to lymphocyte subsets Get access J. B. MATTHEWS, J. B. MATTHEWS Department of Oral Pathology, University of Birmingham, Birmingham Dr J. B. Matthews, Immunology Laboratory, Department of Oral Pathology, The Dental School, St Chad's Queensway, Birmingham B4 6NN, U. K. Search for other works by this author on: Oxford Academic Google Scholar C. M. SCULLY, C. M. SCULLY Department of Oral Medicine and Oral Surgery, University of Bristol, Bristol, U.K. Search for other works by this author on: Oxford Academic Google Scholar A. J. C. POTTS A. J. C. POTTS Department of Oral Pathology, University of Birmingham, Birmingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 5, 1 November 1984, Pages 587–595, https://doi.org/10.1111/j.1365-2133.1984.tb06629.x Published: 01 November 1984 Article history Accepted: 20 April 1984 Published: 01 November 1984
Cold facts concerning hypothermia
Authors: Phil Gunby
Journal: JAMA (1980)

A woman is found in the snow with much of her clothing removed. Looking at the cold, still body, police conclude that she may have been raped and murdered during the night. They begin to cordon off the area and urge others at the scene, including a physician, to stay away from the body in order to preserve clues. As underwater oil exploration proceeds in the North Sea, an average of six divers a year die. For at least half of these deaths, there is no—or only a partial—explanation. In addition, many other divers do not die but suffer unexplained confusion or loss of consciousness. Virtually all participants in a recent Kingston, RI, conference would counsel the physician in the first case not to be put off by the police but to examine the woman. The main reason? She may not be dead. An oft repeated maxim in
The role of lymphocytes in the experimental progressive glomerulonephritis
Authors: Yohei Ikezumi, Katsue Kanno, Tamaki Karasawa, Gi Dong Han, Yumi Ito, Hiroko Koike, Shinichi Toyabe, Makoto Uchiyama, Fujio Shimizu, Hiroshi Kawachi
Journal: Kidney International (2004)
453 Apolipoprotein H and E gene polymorphisms and outcome of hepatitis B virus infection
Authors: M. Burlone, R. Minisini, C. Fabris, E. Caldera, D. Bitetto, E. Falleti, C. Smirne, S. Grazioli, P. Toniutto, M. Pirisi
Journal: Journal of Hepatology (2006)
ANGINA AND ANTI-ANGINAL THERAPY IN WOMEN WITH SIGNS AND SYMPTOMS OF ISCHEMIA AND NO OBSTRUCTIVE CORONARY ARTERY DISEASE
Authors: Puja K. Mehta, Tara Sedlak, Tanya Kenkre, B. Delia Johnson, Chrisandra Shufelt, John Petersen, Babak Azarbal, Bruce Samuels, R. Anderson, Leslee Shaw, Saibal Kar, Eileen Handberg, Sheryl Kelsey, Carl Pepine, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2013)
Iodinating activity of thyroid tissue in toxic diffuse goiter.
Authors: S Nagataki, H Uchimura, H Ikeda, N Kuzuya, Y Masuyama
Journal: Journal of Clinical Investigation (1977)

Thyroid tissue obtained from 12 patients with Graves' disease and treated with thionamide drugs for 3-7 mo before subtotal thyroidectomy, from 12 patients with Graves' disease, similarly treated, and given 50 mug of triiodothyronine (T3) for 10 days before surgery, and from 12 euthyroid patients with solitary cold nodules was investigated to compare in vitro iodination of thyroglobulin in toxic diffuse goiter and in normal thyroid tissue. The supernates of the homogenates (105,000g) were subjected to sucrose density gradient centrifugation (5--28%) to separate the thyroglobulin fraction. The precipitates were treated with 1% digitonin and centrifuged to collect the supernate (particulate fraction). When thyroglobulin and particulate fractions obtained from the same patient were incubated with 125I-, iodide, glucose, and glucose oxidase, the amount of iodine bound to thyroglobulin was several times greater in toxic diffuse goiter than in normal thyroid tissue; administration of T3 did not affect iodination in toxic diffuse goiter. When the thyroglobulin fraction from each patient was incubated with a standardized quantity of peroxidase instead of the individual particulate fraction, the amount of iodine bound to thyroglobulin was the same among the three groups of patients. Finally, when bovine serum albumin was substituted for thyroglobulin from each of the patients, iodination of bovine serum albumin was several times greater with the particulate fraction obtained from toxic diffuse goiter tissue than with that obtained from normal tissue. The guaiacol-oxidizing activity oty. These results suggest that in vitro iodination of thyroglobulin is increased in toxic diffuse goiter even when patients are made euthyroid by treatment with thionamide drugs as well as when they are given additional T3 for 10 days before operation. The increase in iodination of thyroglobulin appears to be due to an increase in peroxidase activity in the particulate fraction.
Intraperitoneal Urine Leak Following Renal Transplant
Authors: BOHDAN BYBEL, I. DAVID GREENBERG
Journal: Clinical Nuclear Medicine (1998)

A 47-year-old man with chronic renal failure underwent renal transplantation. He remained anuric and was diagnosed with an intraperitoneal urine leak by Tc-99m MAG3 renal scintigraphy. The diagnosis was confirmed by imaging fluid withdrawn via the peritoneal dialysis catheter.
Abstract 2023: The role of RASSF1A in FasL expression and function
Authors: Janaki Perera, Jordyn Burger, Sadie Aznavoorian-Cheshire, Joanne C. Pratt
Journal: Cancer Research (2012)

Abstract RASSF1A is a tumor suppressor protein that is epigenetically silenced in a variety of tumor cells, including those of lymphocytic origin. Several previous studies have identified a role for RASSF1A in death receptor-dependent apoptosis in abnormal cells of epithelial origin downstream of tumor necrosis factor receptor 1 (TNF-R1) engagement; however relatively little is known about a possible role for Rassf1A in lymphocytic cells. Interaction of Fas ligand (FasL) on activated T lymphocytes with the Fas receptor on other immune cells plays a major role in down-modulating immune responses through activation-induced cell death (AICD). Apoptosis of T cells that have undergone clonal expansion in response to antigenic stimulation through the TCR is a key regulatory feature of the adaptive immune response that prevents the accumulation of excessive lymphocytes once the antigen has been cleared. We have examined the effect of RASSF1A overexpression on FasL transcriptional activation and function in the Jurkat human T cell line. We have demonstrated that over-expression of RASSF1A induced a significant increase in FasL promoter (FasLp) activity. Similar-fold increases in transcriptional activity were observed when the distal NFAT binding site (3X NFAT plus minimal promoter) within FasLp was used in co-transfection reporter assays; however, other transcription reporters (AP1, NFkB) were unaffected. Experiments with mutant Jurkat cell lines indicate that early signaling mediators, including tyrosine kinases and PLCγ, are critical in the RASSF1A-induced enhancement of FasL production. Poly (ADP-ribose) polymerase (PARP) cleavage is mediated by caspases, and is indicative of apoptosis. Supernatants from anti-CD3 stimulated Jurkat cells that stably overexpress RASSF1A show an increased ability to induce cleavage of PARP in apoptosis-sensitive J16 target cells when compared to anti-CD3 stimulated vector-transfected cells. Taken together, these results indicate that RASSF1A plays a role in expression of soluble FasL leading to increased apoptosis-inducing activity by these lymphocytic cells. The loss of this activity could contribute to outgrowth of malignant clones of lymphocytic origin in which RASSF1A is silenced. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2023. doi:1538-7445.AM2012-2023
Pneumoconiosis in Pennsylvania's Bituminous Mining Industry
Authors: Jan Lieben
Journal: JAMA (1963)

The extent of the pneumoconiosis problem in the Pennsylvania bituminous coal industry has been under discussion for some time. Some believe that there is a problem and others deny its existence. A satisfactory answer to this question cannot be found in the literature. Therefore, more than 16,000 working and retired coal miners in the central and western Pennsylvania bituminous coal districts were screened over a 3-year period. An occupational, personal history, vital capacity, and 14-by-17-in chest xray were obtained on each man. In the study of over 5,000 bituminous miners in central Pennsylvania, 34% were found to have roentgen evidence of pneumoconiosis, whereas 14% of the 10,000 western Pennsylvania bituminous miners studied showed such evidence.
Great Paths Cross: Freud and James at Clark University, 1909
Authors: ROBERT I. SIMON
Journal: American Journal of Psychiatry (1967)

The historic meeting of Freud and James at Clark University, where Freud presented his first exposition of psychoanalysis in America, is described. The reactions of these two great men to the encounter are recalled, and the author speculates as to the possible outcome of further dialogue between them had the illness and death of James not intervened.
Report shows doubling of care staff in Wales sacked for alleged abuse
Authors: R. Dobson
Journal: BMJ (2009)

<h3>Background</h3> Shift work is a feature of many occupations and has been associated with a range of adverse health outcomes, including obesity, diabetes, depression and cancer. The main proposed mechanism linking them is a disruption in circadian rhythms, particularly among night shift workers. DNA methylation may serve as a biomarker for circadian disruption and a potential mechanism by which shift work influences disease risk. In the context of a longitudinal study, we aimed to investigate whether shift work is associated with DNA methylation. <h3>Methods</h3> Methylation profiling was performed using Illumina EPIC micro-arrays on whole-blood DNA samples, obtained from British Household Panel Survey (BHPS) participants of <i>Understanding Society</i> from 2010–2012. BHPS comprises a clustered random sample of households recruited in 1991, with all members followed annually. After pre-processing, 1175 samples and 857,071 CpG sites remained for investigation. Shift work variables were derived from 17 time points between 1991 and 2009: ever (n=359), current (n=88) and long-term (<sup>3</sup> 3 years) shift work (n=154) (night and rotating). Epigenome-wide association analysis was performed using multivariable regression with adjustment for age, sex, batch and blood processing day. Further models were adjusted for cell-type composition and socio-economic variables. Methylation age was also estimated based on the Horvath epigenetic clock and the impact of shift work on ‘epigenetic age acceleration’ (EAA) was investigated. <h3>Results</h3> In epigenome-wide association analysis, 50 CpG sites were associated with shift work with a nominal p-value&lt;1 × 10<sup>-5</sup> across the 9 main analyses, with the strongest signal of association at cg12880856 (<i>PPARG</i>) identified in relation to ever working night shifts (p=7.3 × 10<sup>−8</sup>). There was nominal evidence for an inverse association between current shift and rotating work with accelerated ageing (EAA) (mean difference=-0.98 (-1.93, -0.39); p=0.041 and −1.11 (−2.19,–0.04); p=0.041, respectively). <h3>Conclusion</h3> Shift work was associated with differential methylation in blood, including a CpG site in <i>PPARG</i>. This CpG site is specific to the Illumina EPIC array, not being present on the predecessor 450 K array, and represents a potentially novel finding. PPAR-gamma has been implicated in the pathology of obesity, diabetes and cancer, although further work is required to appraise the causal effect of methylation on health outcomes. Furthermore, there was some evidence that current shift workers had decelerated methylation age compared with non-shift workers. However, the number of shift workers in this study was relatively small and further validation of findings is required.
The effect of concentration on hepatic transport of exogenous epidermal growth factor
Authors: Susan Jo Burwen, Mary E. Barker, Ira S. Goldman, Albert L. Jones
Journal: Hepatology (1985)

Epidermal growth factor (EGF), taken up by rat liver hepatocytes, is primarily transported to the lysosomes and degraded. However, a small but significant percentage of endocytosed EGF is transported by a nonlysosomal pathway and is secreted intact into bile. There is no information as to the mechanisms that regulate the selection of transport pathway and thereby determine the different metabolic fates for EGF. The experiments reported here were undertaken to determine whether the amount of exogenous EGF administered to the liver (the transport load) might affect the selection of the transport pathway. If “excess” EGF, exceeding some as yet undetermined threshold, is preferentially transported by the lysosomal pathway, then the proportion of degraded EGF secreted into bile should increase as a function of the amount of EGF administered. 125I-EGF (3 to 175 ng) was injected into rat portal veins, and bile samples were collected via cannula. The radioactivity secreted into bile was measured, and the bile samples were immunoprecipitated with anti-EGF antiserum. The proportion of intact vs. degraded EGF in bile was determined by the percentage of immunoprecipitable radioactivity. Regardless of the amount of EGF injected, the pattern of its secretion was unaltered. The percentage of immunoprecipitable EGF in bile was the same for all doses. Therefore, the amount of EGF that was degraded did not change as a function of EGF concentration, implying that the lysosomal pathway was not preferentially utilized as the transport load increased. In conclusion, transport load does not appear to be a regulatory mechanism in the selection of transport pathway utilized by EGF.