tbuckley/cabot-search huggingface dataset:
Pemphigoid nodularis (non-bullous): a clinicopathological study of five cases
Authors: A.M. Powell, S. Albert, M.J. Gratian, R. Bittencourt, B.S. Bhogal, M.M. Black
Journal: British Journal of Dermatology (2002)

Pemphigoid nodularis is a rare clinical variant of pemphigoid characterized by overlapping clinical features of both prurigo nodularis lesions and pemphigoid-like blisters. In pemphigoid nodularis, the immunopathological findings are identical to those of bullous pemphigoid (BP). We describe five patients who presented with the typical clinical phenotype of prurigo nodularis, who were found to have circulating and tissue-bound antibasement membrane zone autoantibodies. By immunoelectron microscopy and Western immunoblotting studies, the circulating antibodies were shown to target the hemidesmosome and specifically the BP antigens 1 and 2 (BP180 and BP230). In contrast to the majority of reported cases, none of these patients has ever developed blisters. The role of antibasement membrane zone antibodies in the development of the eruption, or the role of the eruption in the development and persistence of autoantibodies, is not clear. These cases demonstrate that the presence of these antibodies is not sufficient for the development of blisters.
NHS complaints system is letting patients down
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

A sound ethical framework for research in developing countries is crucial for ensuring that participants are safe from exploitation, says a report from the Nuffield Council on Bioethics.But some of the measures introduced to try to offer such protection-such as arguing that participants should have access to the same standards of care made available in developed countries-are impractical and can undermine potential research opportunities, it says.The conclusions follow a discussion paper issued by the council in 2002 and a subsequent meeting in Cape Town, South Africa, in February 2004, attended by 58 participants from 28 countries, including India, China, Kenya, and Botswana.The discussion paper published by the council looks at the current laws governing research in developing countries, including the 1964 Declaration of Helsinki, which has since been amended five times by the World Medical Association and clarified by the Council for International Organizations of Medical Sciences.Research in developing countries is crucial, the paper says, for improving health care.But researchers in these countries often cannot conduct their own research, making partnership with more developed countries essential.
Alternative Modes of Cyclophosphamide and Azathioprine Therapy in Lupus Nephritis
Authors: Huibert J. Dinant, John L. Decker, John H. Klippel, James E. Balow, Paul H. Plotz, Alfred D. Steinberg
Journal: Annals of Internal Medicine (1982)

Forty-one patients with systemic lupus erythematosus and glomerulonephritis were studied in a randomized drug trial. Thirteen patients received prednisone only (Group I), 16 received oral cyclophosphamide and oral azathioprine (1 mg/kg body weight d of each initially) (Group 2), and 12 were given boluses of intravenous cyclophosphamide (0.5 to 1.0 g/m2 body surface area every 3 months) (Group 3). The mean observation period was 42 months (range 1 to 6.5 years). Renal function deteriorated in four of 12 patients in Group 1 and three of 27 patients in Groups 2 and 3 (p = 0.114). By life-table analysis, 86% of the entire group survived 5 years after entry to the study. Marked hypertension, fluctuating changes in serum creatinine, erratic changes in levels of antibody to DNA, reduced C3 levels, increasing proteinuria or sustained hematuria, and flares of extrarenal disease activity occurred more commonly in Group 1. Infectious complications were not commoner in Groups 2 and 3. We conclude that any marginal benefits produced by the programs tested cannot be shown in this class of patients without markedly increasing the sample size. Our current studies involve more vigorous treatment of patients with more acute disease and less treatment during prolonged periods of relatively good health.
Diagnosis-specific sickness absence as a predictor of mortality: the Whitehall II prospective cohort study
Authors: J. Head, J. E Ferrie, K. Alexanderson, H. Westerlund, J. Vahtera, M. Kivimaki
Journal: BMJ (2008)

<b>Objective</b> To investigate whether knowing the diagnosis for sickness absence improves prediction of mortality. <b>Design</b> Prospective cohort study established in 1985-8. Sickness absence records including diagnoses were obtained from computerised registers. <b>Setting</b> 20 civil service departments in London. <b>Participants</b> 6478 civil servants aged 35-55 years. <b>Main outcome measures</b> All cause, cardiovascular, and cancer mortality until 2004, average follow-up 13 years. <b>Results</b> After adjustment for age, sex, and employment grade, employees who had one or more medically certified spells of sickness absence (&gt;7 days) in a three year period had a mortality 1.7 (95% CI 1.3 to 2.1) times greater than those with no medically certified spells. Inclusion of diagnoses improved the prediction of all cause mortality (P=0.03). The hazard ratio for mortality was 4.7 (2.6 to 8.5) for absences with circulatory disease diagnoses, 2.2 (1.4 to 3.3) for surgical operations, and 1.9 (1.2 to 3.1) for psychiatric diagnoses. Psychiatric absences were also predictive of cancer mortality (2.5 (1.3 to 4.7)). Associations of infectious, respiratory, and injury absences with overall mortality were less marked (hazard ratios from 1.5 to 1.7), and there was no association between musculoskeletal absences and mortality. <b>Conclusions</b> Major diagnoses for medically certified absences were associated with increased mortality, with the exception of musculoskeletal disease. Data on sickness absence diagnoses may provide useful information to identify groups with increased health risk and a need for targeted interventions.
COLON FILLING STATIONS
Authors: Anthony Bassler
Journal: JAMA (1927)

<h3>To the Editor:</h3> —History repeats itself. For years the spas in England and on the continent of Europe had bath attendants whose main work was to lavage the colons of persons who believed that they had colitis. Waters of mysterious virtues from salt to brimstone were introduced below to wash out above, and nobody in this country knew or cared much about it. Combe (L'autointoxication, page 513), a physician of some fame in his day as a serious student of biologic disorders, wrote distinctly about it and presented all that the most conspicuous exponents of this method of treatment have done, are doing today or can do in the future. Years ago he pointed out that by it we were able to wash out the supposedly inimicable proteolytic organisms occurring only in the large intestine; that it was possible to wash out as far as the cecum and to remove
Genetic Variation on Chromosome 1 Associated With Variation in Body Fat Distribution in Men
Authors: Robert A. Hegele, J. Howard Brunt, Philip W. Connelly
Journal: Circulation (1995)

Background Interindividual variation in fat deposition in swine is determined by loci on porcine chromosome 4, which are contained in a region that is syntenic with part of the long arm of human chromosome 1. We hypothesized that genomic variation of chromosome 1q would be associated with variation in the ratio of waist-to-hip circumference in male North American Hutterites, a genetic isolate characterized by significant relatedness and sharing of environmental factors. Methods and Results In 316 male Hutterites, we tested for phenotype-genotype association of two DNA polymorphisms on chromosome 1q and the ratio of waist-to-hip circumference. We included control loci on 10 other chromosomes in the multivariate model. We observed that DNA variation on chromosome 1q was significantly associated with variation in the ratio of waist-to-hip circumference in men ( P =.0029). Conclusions The association of DNA variation chromosome 1q with the ratio of waist-to-hip circumference in male Hutterites suggests that there are important structural elements in this genomic region that have a functional impact on body fat distribution.
Sex Differences in Long-Term Mortality after Myocardial Infarction
Authors: Viola Vaccarino, Robert J. Goldberg
Journal: Annals of Internal Medicine (2001)

Letters18 December 2001Sex Differences in Long-Term Mortality after Myocardial InfarctionViola Vaccarino, MD, PhD and Robert J. Goldberg, PhDViola Vaccarino, MD, PhDEmory University School of Medicine; Atlanta, GA 30306University of Massachusetts Medical School; Worcester, MA 01655Search for more papers by this author and Robert J. Goldberg, PhDEmory University School of Medicine; Atlanta, GA 30306University of Massachusetts Medical School; Worcester, MA 01655Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-12-200112180-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Ayus and Arieff, Dr. Franco-Bronson and coworkers, and Dr. Friedman present interesting hypotheses regarding possible underlying mechanisms for the higher mortality risk in younger women compared with men. Drs. Ayus and Arieff hypothesize that the effects of sex hormones on the regulation of the myocardial circulation, possibly mediated by vasopressin, may lead to increased coronary vasoconstriction. Although, as they note, these effects have been described in the cerebral circulation in the setting of hyponatremic encephalopathy, it is unknown whether similar effects apply to the coronary circulation. There is some evidence, however, that women are more subject to ...Reference1. Kimball BP, LiPreti V, Aldridge HE. Quantitative arteriographic responses to ergonovine provocation in subjects with atypical chest pain. Am J Cardiol. 1989;64:778-82. [PMID: 2801529] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Viola Vaccarino, MD, PhD; Robert J. Goldberg, PhDAffiliations: Emory University School of Medicine; Atlanta, GA 30306University of Massachusetts Medical School; Worcester, MA 01655 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSex Differences in 2-Year Mortality after Hospital Discharge for Myocardial Infarction Viola Vaccarino , Harlan M. Krumholz , Jorge Yarzebski , Joel M. Gore , and Robert J. Goldberg Sex Differences in Long-Term Mortality after Myocardial Infarction J. Carlos Ayus and Allen I. Arieff Sex Differences in Long-Term Mortality after Myocardial Infarction Kathleen Franco-Bronson , Marijo Tamburrino , and Nicolle McGowan Sex Differences in Long-Term Mortality after Myocardial Infarction Ernest H. Friedman Metrics 18 December 2001Volume 135, Issue 12Page: 1090-1091KeywordsAnxietyBrain diseasesDeath ratesForecastingMortalityMyocardial infarctionPatientsSex hormonesVasoconstrictionVasopressin ePublished: 18 December 2001 Issue Published: 18 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Susceptible periods during embryogenesis of the heart and endocrine glands.
Authors: T W Sadler
Journal: Environmental Health Perspectives (2000)

One of the original principles of teratology states that, "Susceptibility to teratogenesis varies with the developmental stage at the time of exposure to an adverse influence" [Wilson JG. Environment and Birth Defects. New York:Academic Press, 1973]. The time of greatest sensitivity encompasses the period of organ formation during weeks 3-8 following fertilization in human gestation. At this time, stem cell populations for each organ's morphogenesis are established and inductive events for the initiation of differentiation occur. Structural defects of the heart and endocrine system are no exception to this axiom and have their origins during this time frame. Although the function and maturation of these organs may be affected at later stages, structural defects and loss of cell types usually occur during these early phases of development. Thus, to determine critical windows for studying mechanisms of teratogenesis, it is essential to understand the developmental processes that establish these organs.
Shear stress induction of the tissue factor gene.
Authors: M C Lin, F Almus-Jacobs, H H Chen, G C Parry, N Mackman, J Y Shyy, S Chien
Journal: Journal of Clinical Investigation (1997)

Using flow channel, we report that the application of a laminar shear stress induced a transient increase of tissue factor (TF) procoagulant activity in human umbilical vein endothelial cells (HUVEC), which was accompanied by a rapid and transient induction of the TF mRNA in the HUVEC. Functional analysis of the 2.2 kb TF 5' promoter indicated that a GC-rich region containing three copies each of the EGR-1 and Sp1 sites was required for induction. Mutation of the Sp1 sites, but not the EGR-1 sites, attenuated the response of TF promoter to shear stress. Thus, Sp1 is a newly defined shear stress responsive element. Electrophoretic mobility shift assays showed there was no increase in binding of nuclear extracts from sheared cells to an Sp1 consensus site. In contrast, immunoblotting of these nuclear extracts with antibody against transcription factor Sp1 demonstrated that shear stress increased the phosphorylation of Sp1. We also showed that shear stress, like the phosphatase inhibitor okadaic acid, increased the transcriptional activity of Sp1. These findings suggest that the shear stress induction of TF gene expression is mediated through an increased Sp1 transcriptional activity with a concomitant hyperphosphorylation of Sp1.
Two-dimensional echocardiographic recognition of ruptured chordae tendineae.
Authors: G S Mintz, M N Kotler, B L Segal, W R Parry
Journal: Circulation (1978)

Real-time, phased-array, two-dimensional echocardiographic studies identified ruptured chordae tendineae in five patients: four patients had a flail mitral valve and one had flail mitral and tricuspid valves. The characteristic abnormality was a rapid systolic motion of the involved leaflet beyond the line of valve closure into the atrium. The maximal abnormal systolic motion was greatest at the tip of the leaflet with a loss of the normal coaptation point. By contrast, the two-dimensional echocardiographic feature of mitral valve prolapse is an abnormal systolic motion that is maximal in the body of the leaflet with intact leaflet coaptation. Thus, two-dimensional echocardiography can identify flail mitral and tricuspid valves and is useful in distinguishing ruptured chorade from valvular prolapse.
Abstract 5090: Estrogen receptor-alpha promotes multi-centrosomes by inhibition of BRCA1-Rad51 binding
Authors: Youn-Sang Jung, Ho-Young Chun, Tae-Gyun Woo, Bum-Joon Park
Journal: Cancer Research (2014)

Abstract Von Hippel Lindau gene (VHL) is frequently deleted in renal cell carcinoma and known to be negative regulator of Hypoxia inducible factor-1 (HIF-1). However, its tumor suppressive functions has not been fully explained by HIF-1 suppression, because loss of pVHL is appeared in initial stage of RCC tumorigenesis and induces the defect in cytokinesis or centrosome instability. Concerning this, we previously revealed that estrogen receptor-alpha is primary target of E3 ligase function of pVHL. In this study, we demonstrate that ER-α is responsible for mitotic defect and drug resistance in VHL-deficient cells. Activated ER-α can interact with BRCA1 or Rad51 and disrupt the BRCA1-Rad51-mediated centrosome maintaining. Thus, VHL-deficient cells, like as BRCA1-deficient cells, possessed multi-centrosome and multi-nucleated phenotypes. In addition, multi-centrosomal features rendered the resistance to Taxol. Since it is mediated by ER-α in nucleus, blocking of ER-α translocation by specific inhibitor, Faslodex, can ameliorate multi-centrosomes and induce Taxol sensitivity in RCC and BRCA1-deficient breast cancers. These results suggest that pVHL is critical for proper cell division and suppression of ER-α in RCC and BRCA1-deficient breast cancer is one of useful strategy for improving the drug sensitivity. Citation Format: Youn-Sang Jung, Ho-Young Chun, Tae-Gyun Woo, Bum-Joon Park. Estrogen receptor-alpha promotes multi-centrosomes by inhibition of BRCA1-Rad51 binding. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5090. doi:10.1158/1538-7445.AM2014-5090
Physicians' Health Practices Are Better Than Patients’—Reply
Authors: Kenneth Mukamal, Benjamin Helfand
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Renal Vein Thrombosis
Authors: DONALD E. BUTKUS
Journal: Annals of Internal Medicine (1975)

Comments1 December 1975Renal Vein ThrombosisDONALD E. BUTKUS, M.D.DONALD E. BUTKUS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-901 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the July issue, Llach, Arieff, and Massry (1) reported from a careful, prospective study that they had detected an alarmingly high incidence (33%) of renal vein thrombosis in patients with the nephrotic syndrome, which in most cases was secondary to membranous and membranoproliferative glomerulonephritis. Of equal concern was the finding that the majority of patients had no symptoms, laboratory findings, or radiographic clues on intravenous pyelography to suggest that renal vein thrombosis was present. They point out that the prognosis, as far as rapid deterioration of renal function is concerned, is not as ominous as has...Reference1. LLACHARIEFFMASSRY FAS: Renal vein thrombosis and nephrotic syndrome. A prospective study of 36 adult patients. Ann Intern Med 83:8-14, 1975 LinkGoogle Scholar1. TREWBIAVAJACOBS PCR: Renal vein thrombosis (RVT) and membranous glomerulonepathy: incidence and relationship (abstract). 7th Annual Meeting of American Society of Nephrology Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nephrology Service Fitzsimons Army Medical Service Denver, Colorado 80240 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliography 1 December 1975Volume 83, Issue 6Page: 901-902KeywordsGlomerulonephritisIntravenous pyelographyProspective studiesResearch laboratoriesVeins Issue Published: 1 December 1975 PDF downloadLoading ...
Response to CCR-07-0070
Authors: William Pao, Yixuan Gong, Marissa Balak
Journal: Clinical Cancer Research (2007)

In Response: We appreciate the comments from Dr. Toyooka and his colleagues with regard to our article entitled “Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor (EGFR)–mutant lung adenocarcinomas with acquired resistance to kinase inhibitors” ([1][1]). In
Minimum information needed by prescribers.
Authors: A Herxheimer, N D Lionel
Journal: BMJ (1978)

The prescriber needs adequate and concise information about each product that he uses, to allow him to obtain optimal effects while minimising harm. Neither the present UK data sheets nor their equivalents in other countries have succeeded in providing such information clearly or completely. This paper develops the proposals on the arrangement of drug information made in the WHO report "The selection of essential drugs." Three sets of minimum information (on tetracycline, propranolol, and aspirin) which illustrate this approach were compared with the manufacturers' data sheets: the latter were incomplete. The information content of our proposals was worked out with a group of clinical pharmacologists, general practitioners, and specialists, and we suggest that this approach should be extended to other drugs.
Feasibility of outpatient consolidation chemotherapy in older versus younger patients with acute myeloid leukemia
Authors: Lalit Saini, Mark D. Minden, Andre C. Schuh, Karen W.L. Yee, Aaron D. Schimmer, Vikas Gupta, Eshetu G. Atenafu, Cindy Murray, Shannon Nixon, Joseph M. Brandwein
Journal: American Journal of Hematology (2011)

Intensive consolidation chemotherapy for acute myeloid leukemia (AML) patients in complete remission is being increasingly administered on an outpatient basis. Although this approach has been found to be safe and feasible in younger patients, its safety in older patients remains unknown. We therefore undertook an evaluation of outpatient-based consolidation chemotherapy in older AML patients, and compared results to younger patients treated at the same institution over the same time period. The overall rate of readmission was ~50%, mostly for infections, with mean admission duration of 2 weeks. The overall mortality rate was 2.2%. Readmission rates and duration of readmission were somewhat higher in older patients, but infection rate, intensive care (ICU) admissions, and mortality rates were comparable to those in the younger patient cohort. However, we also observed that rates of febrile neutropenia, bacteremia, ICU admission, and death were significantly higher during the second consolidation, as compared with the first, in both younger and older patients. We conclude that outpatient-based consolidation therapy can be safely undertaken in a substantial proportion of fit older patients with AML.
Double effect is a myth leading a double life
Authors: Claud Regnard
Journal: BMJ (2007)

Kelly Taylor's request to use morphine “to make her unconscious” under the principle of double effect is a puzzling choice.1

Evidence over the past 20 years has repeatedly shown that, used correctly, morphine is well tolerated and does not shorten life or hasten death.2 Its sedative effects wear off quickly (making it useless …