The Hemolytic-Uremic Syndrome: Recovery After Treatment with Vincristine
Authors: LORENCE A. GUTTERMAN
Journal: Annals of Internal Medicine (1983)

Brief Reports1 May 1983The Hemolytic-Uremic Syndrome: Recovery After Treatment with VincristineLORENCE A. GUTTERMAN, M.D., DOUGLAS M. LEVIN, M.D., BARRY S. GEORGE, M.D., HARI M. SHARMA, M.D.LORENCE A. GUTTERMAN, M.D.Search for more papers by this author, DOUGLAS M. LEVIN, M.D.Search for more papers by this author, BARRY S. GEORGE, M.D.Search for more papers by this author, HARI M. SHARMA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-612 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hemolytic-uremic syndrome is characterized by renal thrombotic microangiopathy, including acute renal failure, microangiopathic hemolytic anemia, and consumptive thrombocytopenia (1). End-stage histologic changes in the liver have also been reported in this syndrome (2). We report the case of a woman with the hemolytic-uremic syndrome who had evidence of early microscopic hepatocellular abnormalities. All manifestations of her illness subsided after vincristine sulfate therapy was given. Her recovery seemed to result from this therapy because no other treatment was administered. This drug therapy was given because of the successful treatment of thrombotic thrombocytopenic purpura with vincristine (3).A 45-year-old dental hygienist...References1. KAPLANDRUMMOND BK. The hemolytic-uremic syndrome is a syndrome [Editorial]. N Engl J Med. 1978;298:964-6. CrossrefMedlineGoogle Scholar2. CLARKSONLAWRENCEMEADOWSSEYMOUR AJRA. The haemolytic-uraemic syndrome in adults. Q J Med. 1970;39:227-44. MedlineGoogle Scholar3. GUTTERMANSTEVENSON LT. Treatment of thrombotic thrombocytopenic purpura with vincristine. JAMA. 1982;247:1433-6. CrossrefMedlineGoogle Scholar4. SHERLOCK S. Patterns of hepatocyte injury in man. Lancet. 1982;1:782-6. CrossrefMedlineGoogle Scholar5. ANTONOVYCHMOSTOFI TF. Atlas of Kidney Biopsies. Washington, D.C.: Armed Forces Institute of Pathology; 1980:237. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Riverside Methodist Hospital and The Ohio State University Hospitals Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHematologic Complications of PregnancyHematologic Complications of PregnancyA review of hemolytic uremic syndrome in patients treated with gemcitabine therapyVincristine sulfate for the treatment of thrombotic thrombocytopenic purpura refractory to plasma-exchangeThrombotic thrombocytopenic purpura: Prospective treatment with a standardized regimenThe clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeuticsRapid improvement of thrombotic thrombocytopenic purpura with vincristine and plasmapheresisHUS and TTP: Variable expression of a single entityHemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin 1 May 1983Volume 98, Issue 5_Part_1Page: 612-613KeywordsAcute renal failureBiopsyDrug therapyHemolytic anemiaHemolytic-uremic syndromeLiverSulfatesThrombotic thrombocytopenic purpura Issue Published: 1 May 1983 PDF DownloadLoading ...