tbuckley/cabot-search huggingface dataset:
Reperfusion damage: free radicals mediate delayed membrane changes rather than early ventricular arrhythmias
Authors: W. A Coetzee, P. Owen, S. C Dennis, S. Saman, L. H Opie
Journal: Cardiovascular Research (1990)

Journal Article Reperfusion damage: free radicals mediate delayed membrane changes rather than early ventricular arrhythmias Get access William A Coetzee, William A Coetzee Medical Research Council Ischaemic Heart Disease Research Unit, University of Cape Town, Medical School, Observatory, Cape Town 7925, South Africa Correspondence to: Dr Coetzee Search for other works by this author on: Oxford Academic PubMed Google Scholar Patricia Owen, Patricia Owen Medical Research Council Ischaemic Heart Disease Research Unit, University of Cape Town, Medical School, Observatory, Cape Town 7925, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar Steven C Dennis, Steven C Dennis Medical Research Council Ischaemic Heart Disease Research Unit, University of Cape Town, Medical School, Observatory, Cape Town 7925, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar Selva Saman, Selva Saman Medical Research Council Ischaemic Heart Disease Research Unit, University of Cape Town, Medical School, Observatory, Cape Town 7925, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar Lionel H Opie Lionel H Opie Medical Research Council Ischaemic Heart Disease Research Unit, University of Cape Town, Medical School, Observatory, Cape Town 7925, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 2, February 1990, Pages 156–164, https://doi.org/10.1093/cvr/24.2.156 Published: 01 February 1990 Article history Received: 04 January 1989 Accepted: 04 September 1989 Published: 01 February 1990
Open access echocardiography
Authors: J. J Murphy, C. M Bossingham
Journal: BMJ (1995)

EDITOR,--C M Francis and colleagues report their experience with open access echocardiography in the management of heart failure in Edinburgh.1 General practitioners were sent a summary of the findings on scanning together with recommendations concerning changes to treatment, although the authors present no information to show that such changes were implemented.

A pilot open access service is available to general practitioners in Darlington, and over 200 patients have been referred. Before …
Abstract 3545: Alterations of molecular mechanisms in newly selected 5-fluorouracil resistant pancreatic cancer cell line and the effect of biochanin A thereon
Authors: Vikas Bhardwaj, James C.K. Lai, Alok Bhushan
Journal: Cancer Research (2010)

Abstract Resistance to drugs is one of the major contributor to the high mortality rate of pancreatic cancer. The molecular mechanisms of pancreatic cancer drug resistance are not well understood. We generated and characterized a 5FU resistant pancreatic cancer cell line (AsPC1/R). 5FU resistant pancreatic cancer cells (AsPC1/R) were selected with the increasing concentration of the drug till 6-fold resistance was achieved. Our dose response studies show that the resistant cells were cross-resistant to the gefitinib; however, the sensitivity to gemcitabine was not altered. Western blot analysis shows lower level of EGFR in the AsPC1/R as compared to AsPC1 cells. In addition, our results indicate that the resistant cells have high levels of activated Erk 1 and Akt. Levels of c-fos and c-jun in the nuclear fraction were upregulated in the resistant cells. Furthermore, invasive mechanisms such as uPAR and MMP activity are upregulated in the AsPC1/R cells compared to the parent cells. We also determined the effect of biochanin A on 5FU resistance and found that it reverses the 5FU resistance in AsPC1/R cells. Our previous studies have shown that biochanin A reduces the levels of thymidylate synthase and the levels of activated Erk and Akt. We conclude that biochanin A may overcome 5FU resistance in pancreatic cancer and could be used in combination with other chemotherapeutic agents in treating pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3545.
Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation
Authors: Covadonga Pañeda, Itziar Gorospe, Blanca Herrera, Toshikazu Nakamura, Isabel Fabregat, Isabel Varela-Nieto
Journal: Hepatology (2002)

Regulation of liver cell proliferation is a key event to control organ size during development and liver regeneration. Methionine adenosyltransferase (MAT) 2A is expressed in proliferating liver, whereas MAT1A is the form expressed in adult quiescent hepatocytes. Here we show that, in H35 hepatoma cells, growth factors such as hepatocyte growth factor (HGF) and insulin up-regulated MAT2A expression. HGF actions were time- and dose-response dependent and required transcriptional activity. Mitogen-activated protein (MAP) kinase and phosphatidylinositol 3-phosphate kinase (PI 3-K) pathways were required for both HGF-induced cell proliferation and MAT2A up-regulation. Furthermore, in H35 cells treated with HGF, the inhibition of these pathways was associated with the switch from the expression of fetal liver MAT2A to the adult liver MAT1A isoform. Fetal liver hepatocytes exhibited an identical response pattern. Treatment of H35 hepatoma cells with MAT2A antisense oligonucleotides decreased cell proliferation induced by HGF; this decrease correlated with the decay in MAT2A messenger RNA (mRNA) levels. Finally, growth inhibitors such as transforming growth factor (TGF) beta blocked HGF-induced MAT2A up-regulation while increasing MAT1A mRNA levels in H35 cells. In conclusion, our results show that MAT2A expression not only correlates with liver cell proliferation but is required for this process.
Dendrimeric poly(propylene-imines) as effective delivery agents for DNAzymes: Toxicity, in vitro transfection and in vivo delivery
Authors: F. Tack, A. Bakker, S. Maes, N. Dekeyser, M. Bruining, C. Elissen-Roman, M. Janicot, H.M. Janssen, B.F.M. De Waal, P.M. Fransen, X. Lou, E.W. Meijer, A. Arien, M.E. Brewster
Journal: Journal of Controlled Release (2006)
Endoscopic fine needle aspiration cytology in the diagnosis of gastro-oesophageal and colorectal malignancies.
Authors: S A Zargar, M S Khuroo, R Mahajan, G M Jan, K Dewani, V Koul
Journal: Gut (1991)

In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave the highest diagnostic accuracy (94%), which was significantly better than that of brush cytology (84.9%) and biopsy (87.2%) (p less than 0.005). The difference was mainly related to tumour pattern. When compared to brush cytology and biopsy aspiration cytology was significantly better in submucosal tumours (92.9% v 7.1% and 14.3%, p less than 0.001); in infiltrative malignancies (95.8% v 90.1% and 78.9%, p less than 0.01), and in ulceronecrotic malignancies (90.9% v 36.4% and 45.4%, p less than 0.05). In polypoid malignancies there was a significant trend (p less than 0.05) in favour of forceps biopsy, with a diagnostic yield of 100% compared with 95% for aspiration cytology and 93.3% for brush cytology. The accuracy of the different techniques was not significantly related to the site of the tumour. The cumulative accuracy of aspiration cytology and biopsy was significantly better than that of biopsy and brush cytology (98.5% v 90.9%, p less than 0.005). Aspiration cytology was diagnostic in 21 of 24 lesions that were negative with both brush cytology and biopsy. There were no false positive cytology or histology results. We conclude that aspiration cytology is a simple, safe, and reliable technique with a high diagnostic yield and is of particular value in submucosal, infiltrative, and ulceronecrotic tumours.
Review of Regional Limb Perfusion with Melphalan for Malignant Melanoma
Authors: W. T. Irvine, R. J. Luck
Journal: BMJ (1966)

Children's Tumours-Steward MRDIC"JoAL also to direct their investigations towards problems of the disease as it affects children. ConclusionIt is realized that centralization makes visiting of children in hospital and out-patient attendance somewhat difficult, and for this reason a case can be made for treating children with leukaemia near their homes.But the initial treatment of those with non-leukaemic tumours rarely lasts more than six weeks, and follow-up need not be very frequent.Everyone realizes that these children are suffering from a desperate disease, and there must be few parents who would not put up with a reasonable amount of inconvenience so long as they believed that their children were getting good treatment; also, this inconvenience could be reduced to a minimum by the provision of accommodation for parents in hospital.It is much easier to collect patients together if they live in a densely populated area.For example, if one centre were set up for the treatment of children with turnours from the Metropolitan regions an enormous contribution could be made.One thing must be accepted.Children's cancer research is a joint responsibility of paediatricians, radiotherapists, surgeons, and pathologists.If the treatment of children's tumours were reorganized new methods could be efficiently assessed and advantage be taken of the great research poten- tial that is available. SummaryEach year 100 children in the Manchester Hospital Region develop tumours, and 70% of these patients die.It is likely that a significant improvement in the survival rate will come only when adjuvant treatment-for example, chemotherapyis used to supplement surgery and x rays.The fact that children with tumours are treated in so many different hospitals hinders the assessment of new techniques and research.It is suggested that these patients are best treated in centres each serving a population of at least one and a half million children.This work could not have been carried out without the ready co-operation of the clinicians and pathologists of the Manchester Region.The organization for treating children with tumours has been criticized in this article.It is hoped that nobody will interpret this as a criticism of any individual-such is certainly not my intention.
Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection
Authors: I. Martin-Loeches, T. Lisboa, A. Rhodes, R. P. Moreno, E. Silva, C. Sprung, J. D. Chiche, D. Barahona, M. Villabon, C. Balasini, R. M. Pearse, R. Matos, J. Rello
Journal: Intensive Care Medicine (2010)
Understanding Marfan's syndrome.
Authors: I Young
Journal: BMJ (1991)

intercourse and maturation.Advice is often sought on participation in exercise,'3 sexual activity, contraception, employment, and insurance.In many cases too few data are available to allow informed decisions.In a recent survey we found that prospective employers and insurers were often extremely cautious about applicants with congenital heart disease because of a perceived risk of premature incapacity and death.In some cases this caution is appropriate, but in people without symptoms or residual abnormalities this approach is unnecessarily harsh.One of the major roles of a specialised cardiac service for young adults would be to define the functional capability and long term survival of patients with congenital heart disease.To care adequately for adults with congenital heart defects a specialised service must be available for referral or consulta- tion.Efforts are being made to determine the provision available in Europe and to organise care.'4The service must be able to deal with both the cardiac problems and the wide range of other medical problems that occur in these patients, to provide expert surgery, and to offer psychosocial support and advice.Concentrating on this group of patients will provide education and opportunities for research for a new specialist group of cardiologists, surgeons, and health professionals.Long term follow up data from such clinics would allow services to be planned and also enable paediatric cardiologists to modify early management to optimise later outcome.With a high level of medical care and psychosocial advice each adult with congenital heart disease would have the best chance of achieving his or her full potential.
Talking about Death with Children Who Have Severe Malignant Disease
Authors: Ulrika Kreicbergs, Unnur Valdimarsdóttir, Erik Onelöv, Jan-Inge Henter, Gunnar Steineck
Journal: New England Journal of Medicine (2004)

One of the questions faced by the parents of a child who is terminally ill with a malignant disease is whether or not they should talk about death with their child.In 2001, we attempted to contact all parents in Sweden who had lost a child to cancer between 1992 and 1997. Among 561 eligible parents, 449 answered a questionnaire, and 429 stated whether or not they had talked about death with their child.None of the 147 parents who talked with their child about death regretted it. In contrast, 69 of 258 parents (27 percent) who did not talk with their child about death regretted not having done so. Parents who sensed that their child was aware of his or her imminent death were more likely to regret not having talked about it (47 percent, as compared with 13 percent of parents who did not sense this awareness in their child; relative risk, 3.7; 95 percent confidence interval, 2.3 to 6.0). The same variable was related to having talked about death (50 percent vs. 13 percent; relative risk, 3.8; 95 percent confidence interval, 2.6 to 5.6), as was being religious (42 percent vs. 25 percent; relative risk, 1.7; 95 percent confidence interval, 1.2 to 2.3). The child's age was related to both having talked about death and the parents' regretting not having talked about it.Parents who sense that their child is aware of his or her imminent death more often later regret not having talked with their child than do parents who do not sense this awareness in their child; overall, no parent in this cohort later regretted having talked with his or her child about death.
Hepatocytes and Epithelial Cells of Donor Origin in Recipients of Peripheral-Blood Stem Cells
Authors: Martin Körbling, Ruth L. Katz, Abha Khanna, Arnout C. Ruifrok, Gabriela Rondon, Maher Albitar, Richard E. Champlin, Zeev Estrov
Journal: New England Journal of Medicine (2002)

Bone marrow contains stem cells with the potential to differentiate into mature cells of various organs. We determined whether circulating stem cells have a similar potential.Biopsy specimens from the liver, gastrointestinal tract, and skin were obtained from 12 patients who had undergone transplantation of hematopoietic stem cells from peripheral blood (11 patients) or bone marrow (1 patient). Six female patients had received transplants from a male donor. Five had received a sex-matched transplant, and one had received an autologous transplant. Hematopoietic stem-cell engraftment was verified by cytogenetic analysis or restriction-fragment--length polymorphism analysis. The biopsies were studied for the presence of donor-derived epithelial cells or hepatocytes with the use of fluorescence in situ hybridization of interphase nuclei and immunohistochemical staining for cytokeratin, CD45 (leukocyte common antigen), and a hepatocyte-specific antigen.All six recipients of sex-mismatched transplants showed evidence of complete hematopoietic donor chimerism. XY-positive epithelial cells or hepatocytes accounted for 0 to 7 percent of the cells in histologic sections of the biopsy specimens. These cells were detected in liver tissue as early as day 13 and in skin tissue as late as day 354 after the transplantation of peripheral-blood stem cells. The presence of donor cells in the biopsy specimens did not seem to depend on the intensity of tissue damage induced by graft-versus-host disease.Circulating stem cells can differentiate into mature hepatocytes and epithelial cells of the skin and gastrointestinal tract.
Anchored multiplex PCR for targeted next-generation sequencing
Authors: Zongli Zheng, Matthew Liebers, Boryana Zhelyazkova, Yi Cao, Divya Panditi, Kerry D Lynch, Juxiang Chen, Hayley E Robinson, Hyo Sup Shim, Juliann Chmielecki, William Pao, Jeffrey A Engelman, A John Iafrate, Long Phi Le
Journal: Nature Medicine (2014)
IL-36R ligands are potent regulators of dendritic and T cells
Authors: Solenne Vigne, Gaby Palmer, Céline Lamacchia, Praxedis Martin, Dominique Talabot-Ayer, Emiliana Rodriguez, Francesca Ronchi, Federica Sallusto, Huyen Dinh, John E. Sims, Cem Gabay
Journal: Blood (2011)
Intravenous glucose tolerance and maintenance haemodialysis.
Authors: E Ferrannini, A Pilo, G Buzzigoli, C Boni, M Tuoni
Journal: BMJ (1977)

MinutesEffect of baropacer stimulation on blood pressure and heart rate during low-( .)and high-( *)dose clonidine treatment.Each point on the graph represents mean value of 4-hourly readings following administration of clonidine or placebo.
Carcinoma of the Kidney Presenting as a Thyroid Nodule
Authors: Mitchell Edson
Journal: JAMA (1963)

THE THYROID gland, although a very vascular structure, is an uncommon site of metastatic involvement. Lucke and Schlumberger1found the thyroid involved in metastatic disease in 1.3% of patients on whom autopsies were performed who had renal adenocarcinoma. The over-all incidence of metastatic lesions in the thyroid is 4%. There are a number of cases reported of patients operated on, with a presumptive diagnosis of primary carcinoma of the thyroid, in whom adenocarcinoma of the kidney was later found to be the primary focus of the malignancy.  Report of a Case  A 40-yr-old white male physician had noted increased tightness of his shirt collars for a period of approximately 6 mo which he attributed to recent weight gain. While shaving, 24 hr before admission, the patient noted a mass over the right lobe of the thyroid gland. He had no other symptoms. Laboratory studies performed on admission included hemogram,
NICE sets out guidelines for hypertension
Authors: Karen Hébert
Journal: BMJ (2004)

Combination drug treatment should be used to treat hypertension, recommends the National Institute for Clinical Excellence (NICE) in its latest guidelines on the diagnosis and management in primary care of essential hypertension in adults.

Previously patients would be given one antihypertensive drug, and if this failed to control their blood pressure adequately they would be taken off that drug and given an antihypertensive from another class.

However, after a review of the evidence base, …
Abstract 5178: Evaluation of lumican expression profiles in prostate cancer
Authors: Kazuhiro Yoshimura, Marco A. De Velasco, Yuji Hatanaka, Yutaka Yamamoto, Mitsumasa Kodama, Motoyoshi Tanaka, Nobutaka Shimizu, Masahiro Nozawa, Kazuhiro Yoshikawa, Kazuto Nishio, Hirotsugu Uemura
Journal: Cancer Research (2012)

Abstract The transcription factor, Stat3, has been implicated in the growth and progression of several cancer types including lung skin, liver, ovarian, kidney, colon cancer and prostate. Stat3 has also been shown to induce the metastatic behavior of prostate cancer cells in vitro and in vivo. Activation of Stat3 occurs by the binding of various cytokines to its receptors leading to the activation of the JAK/Stat3 signaling pathway. Of these cytokines, interleukin-6 (IL-6) has been implicated in regulating growth of various malignant tumors and activated IL-6 has been shown to be elevated in the sera from patients with metastatic prostate cancer. In the present study we examined the IL6-induced Stat3 transcriptional activation in the development and progression of prostate cancer and its possible role as a target for the treatment of prostate cancer using the prostate-specific conditional targeting PTEN knockout mouse model. Homozygous PTEN-mutants develop prostate cancer in a stage-specific manner and have the ability to grow and develop castration-resistant prostate cancer after total androgen ablation by castration. ELISA assays revealed increased expression of soluble IL-6 receptor (IL-6R) in tissue lysates from prostate tumors in non-castrated and castrated mice (77.0 ± 6.17 vs. 23.75 ± 5.17 ng/g of tissue, p&amp;lt;0.001, respectively) at 32 weeks of age. Immunohistochemical analysis revealed correlated expression of with Stat3 transcriptional activation, proliferation and androgen receptor in tumors from castrated mice. To determine the role of IL-6R induced transcriptional activation of Stat3, non-castrated and castrated tumor bearing mice were treated with an anti-mouse IL-6R antibody (MR-16). Mice treated with MR-16 showed downregulation of phosphorylated Stat3, however, treatment failed to inhibit tumor development and cellular proliferation. However, it was discovered that therapeutic doses of MR16 treatment resulted in increased phosphorylation of Erk1/2. Our data suggests that inhibition of IL-6R-induced Stat3 activation alone is insufficient to suppress tumor growth; however, further studies need to be conducted to evaluate the efficacy of horizontal combination strategies targeting Stat3 and MAP kinase signaling cascades Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5178. doi:1538-7445.AM2012-5178
On the Use of Oxygen and Strychnine in Pneumonia
Authors: T. L. Brunton, M. Prickett
Journal: BMJ (1892)

troublesome and morphine not contraindicated, I find the following linctus very useful and pleasant: f Liquoris mor- phinaP hydrochlor., 3 j; acidi hydrobromic.dilut., 3 j; chloro- formi pur.iniij; tinct.limonis, 3j; syrupi simp.ad A iss. j3 tussi urgente.Several persons have come to me who have previously suffered from influenza, and have troublesome cough, pain, and slight expectoration, with the peculiar creptitation, left behind.Carbolic acid has cleared these troubles up.The neuralgia which so frequently occurs, especially at the back of the eyeballs, I have found relieved by antipyrin in 7-grain doses, and lately by exalgine in 1-grain doses.
Authors' reply to Gupta
Authors: B. Donovan, H. Ali
Journal: BMJ (2013)

Gupta asks why the national human papillomavirus (HPV) vaccination programme in Australia doesn’t cover women undergoing treatment for high grade cervical disease.1 2

The quadrivalent HPV vaccine was not designed to act as a therapeutic vaccine and theoretically provides no benefit against an existing HPV infection—just as the flu vaccine doesn’t benefit people with flu. Interestingly, a retrospective analysis of data from two randomised placebo controlled trials showed reduced recurrence of …