Continuous Subcutaneous Infusion of Morphine for the Pain of Terminal Malignancy
Authors: CAM F. CAMPBELL
Journal: Annals of Internal Medicine (1983)

Brief Reports1 January 1983Continuous Subcutaneous Infusion of Morphine for the Pain of Terminal MalignancyCAM F. CAMPBELL, M.D., JOEL B. MASON, M.D., JOHN M. WEILER, M.D.CAM F. CAMPBELL, M.D.Search for more papers by this author, JOEL B. MASON, M.D.Search for more papers by this author, JOHN M. WEILER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-51 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral groups have reported successful control of pain in patients with terminal malignancy by the continuous administration of intravenous morphine sulfate (1-3). More recently this therapy has been shown to be of value in managing patients with postoperative pain (4). This mode of administration is used for more effective pain control in patients with severe pain that cannot be satisfactorily controlled by other means of morphine administration (5). Compared with intermittent intramuscular injection, continuous intravenous infusion offers the advantage of substantially reducing patient discomfort, apprehension, and the ecchymoses that often accompany frequent intramuscular or subcutaneous injections. Sometimes the parenteral route...References1. RUTTERMURPHYDUDLEY PFH. Morphine: controlled trial of different methods of administration for postoperative pain relief. Br Med J. 1980;1:12-3. CrossrefGoogle Scholar2. O'DONNELLPAPCIAK LB. When all else fails: continuous morphine infusion for controlling intractable pain. Nursing. 1981;11:69-72. CrossrefMedlineGoogle Scholar3. MISERMISERCLARK AJB. Continuous intravenous infusion of morphine sulfate for control of severe pain in children with terminal malignancy. J Pediatr. 1980;96:930-2. CrossrefMedlineGoogle Scholar4. NAYMAN J. Management of postoperative pain. Aust Fam Phys. 1981;10:276-81. MedlineGoogle Scholar5. MARKSSACHAR RE. Undertreatment of medical inpatients with narcotic analgesics. Ann Intern Med. 1973;78:173-81. LinkGoogle Scholar6. NATHANLOUAVRUCH DPJ. Intensive conventional and insulin pump therapies in adult type I diabetes: a crossover study. Ann Intern Med. 1982;97:31-6. LinkGoogle Scholar7. BERGERCUPPSFAUCI MTA. Immunoglobulin replacement therapy by slow subcutaneous infusion. Ann Intern Med. 1980;93:55-7. LinkGoogle Scholar8. WAYADLER ET. The pharmacologic implications of the fate of morphine and its surrogates. Pharmacol Rev. 1960;12:383-446. MedlineGoogle Scholar9. STANSKIGREENBLATTLOWENSTEIN DDE. Kinetics of intravenous and intramuscular morphine. Clin Pharmacol Ther. 1978;24:52-9. CrossrefMedlineGoogle Scholar10. FRASER D. Intravenous morphine infusion for chronic pain [Letter]. Ann Intern Med. 1980;93:781-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CAM F. CAMPBELL, M.D.; JOEL B. MASON, M.D.; JOHN M. WEILER, M.D.Affiliations: Veterans Administration Medical Center and the University of Iowa Iowa City, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySuccessful Dose Titration to Cancer Pain by Continuous Subcutaneous Injection of Hydromorphone Hydrochloride: A Retrospective AnalysisEffective Switching from High Concentration Morphine Citrate to High Concentration Hydromorphone Citrate for Subcutaneous Induration and Uncontrollable Pain: A Case ReportPharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult PatientsSystematic review of the role of alternative application routes for opioid treatment for moderate to severe cancer pain: An EPCRC opioid guidelines projectContinuous Subcutaneous Infusion of Opiates at End-of-LifeManaging pain and psychological issues in palliative carePalliative Medical OncologySubcutaneous morphine — a simple technique for postoperative analgesiaAllgemeine Kinetik zentraler Schmerzmittel — mit besonderer Berücksichtigung der OpioideA proposed matrix for organisational changes to improve quality of life in oncologyTreatment of Cancer-Related Pain: When Orally Administered Medications FailVerschlußikterus — diagnostische Strategien — „mehr“. 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KERR, M.D., MARCIA SONE, R.N., CARLO DeANGELIS, PHARM.D., NEILL ISCOE, M.D., ROBERT MacKENZIE, M.D., TRUDI SCHUELLER, B.Sc., PHARM.D.Pumps in PharmacotherapyDie palliative Behandlung von terminal TumorkrankenSyringe drivers in palliative care: a reviewAdvances in Control of Cancer PainAmbulatory infusion pumps: A practical view at an alternative approachAlternative drug delivery systemsSyringe driver in terminal care.A validation study of the WHO method for cancer pain reliefCancer Pain Management and Drug DeliveryA chronic sheep preparation for the study of drug pharmacokinetics in spinal and ventricular CSFTHERAPEUTIC PROGRESS—REVIEW XXIII MORPHINE ANALGESIA IN TERMINAL CAREContinuous Intravenous Morphine Infusions for Terminal Pain Control: A Retrospective ReviewThe Treatment of Cancer PainContinuous Subcutaneous Infusion of Narcotics Using a Portable Disposable PumpAnalgesic plasma concentrations of morphine in children with terminal malignancy receiving a continuous subcutaneous infusion of morphine sulfate to control severe painAmbulatory Use of High-Dose Intravenous Morphine for Severe PainSédation des douleurs cancéreuses par injection péridurale quotidienne de morphine grâce à un accès sous-cutané implantéRoutes of Morphine AdministrationMARK N. LOWENTHAL, M.D. 1 January 1983Volume 98, Issue 1Page: 51-52KeywordsHospital medicineIntramuscular injectionsMorphineSubcutaneous injections ePublished: 1 December 2008 Issue Published: 1 January 1983 PDF downloadLoading ...