tbuckley/cabot-search huggingface dataset:
Sclerosant treatment for hydroceles and epididymal cysts.
Authors: J R Nash
Journal: BMJ (1980)

Snail-eating mummy?SIR,-As a parasitologist I was most interested in the review "Buried treasure" by Dr John Cole (1 December, p 1412), which mentioned the finding of a calcified worm of Dracunculus (guinea-worm) in the abdominal wall of a mummy.However, without wishing to appear
TWO YEAR ANALYSIS OF THE SAFETY AND TOLERABILITY OF EVOLOCUMAB: THE OSLER-1 STUDY
Authors: Michael J. Koren, Robert Giugliano, Frederick Raal, David Sullivan, Michael Bolognese, Gisle Langslet, Fernando Civeira, Andrew Lowy, Ransi Somaratne, Thomas Liu, Scott Wasserman, Robert Scott, Marc Sabatine
Journal: Journal of the American College of Cardiology (2015)
MPHOSPH1: A Potential Therapeutic Target for Hepatocellular Carcinoma
Authors: Xinran Liu, Yafan Zhou, Xinyuan Liu, Anlin Peng, Hao Gong, Lizi Huang, Kaige Ji, Robert B. Petersen, Ling Zheng, Kun Huang
Journal: Cancer Research (2014)

MPHOSPH1 is a critical kinesin protein that functions in cytokinesis. Here, we show that MPHOSPH1 is overexpressed in hepatocellular carcinoma (HCC) cells, where it is essential for proliferation. Attenuating MPHOSPH1 expression with a tumor-selective shRNA-expressing adenovirus (Ad-shMPP1) was sufficient to arrest HCC cell proliferation in a manner associated with an accumulation of multinucleated polyploid cells, induction of postmitotic apoptosis, and increased sensitivity to taxol cytotoxicity. Mechanistic investigations showed that attenuation of MPHOSPH1 stabilized p53, blocked STAT3 phosphorylation, and prolonged mitotic arrest. In a mouse subcutaneous xenograft model of HCC, tumoral injection of Ad-shMPP1 inhibited MPHOSPH1 expression and tumor growth in a manner correlated with induction of apoptosis. Combining Ad-shMPP1 injection with taxol administration enhanced antitumor efficacy relative to taxol alone. Furthermore, Ad-shMPP1 tail vein injection suppressed formation of orthotopic liver nodules and prevented hepatic dysfunction. Taken together, our results identify MPHOSPH1 as an oncogenic driver and candidate therapeutic target in HCC.
In-Hospital Cardiopulmonary Resuscitation-Reply
Authors: George E. Taffet
Journal: JAMA (1989)

<h3>In Reply.—</h3> We applaud the efforts of Evers et al, Gregory and Dunn, and Draur and encourage additional studies. Their information assists in meaningful and informed dialogue between patients, families, and physicians in each respective setting. Revealing the differences between populations highlights the importance of our caveats concerning widespread application of our findings. The contribution of future studies will be uncertain without reporting arrest definition, selection ratio, and relationships between gender and outcome. The data in all three studies are notably consistent with other cited CPR studies: the 70 years and older group did more poorly, although ageassociated differences were not statistically significant. Drs Rutherford and Sherman have difficulty in two areas of interpretation with our study. While we submit that a prospective study would allow the neurological consequences of CPR to be assessed more directly, we still believe that our implication that the elderly frequently regain cardiac, but lesser
Intensive Plasma Therapy in the Hemophilias
Authors: Harold R. Roberts, George D. Penick, Kenneth M. Brinkhous
Journal: JAMA (1964)

THE BASIC OBJECTIVE in the clinical management of the hemophilias is to replace the missing plasma procoagulants in quantities sufficient to insure an effective hemostatic mechanism. Currently, the most easily available and least expensive supply of the procoagulants is normal human plasma. The basic principles underlying the use of plasma in the treatment of hemorrhagic crises in patients with classical hemophilia were outlined in 1955.<sup>1</sup>Application of these principles to the treatment of patients with other hereditary hemorrhagic disorders has demonstrated that the majority of bleeding episodes can be adequately treated with plasma alone provided that it is used with appropriate laboratory controls. This report will be limited to our experience with the use of plasma for the prevention or treatment of hemorrhagic episodes in the most common hereditary hemorrhagic disorders, namely classical hemophilia (factor VIII or antihemophilic factor deficiency, hemophilia A ), hemophilia B ( factor IX or plasma thromboplastic
Effects of Physical Training on Exertional S-T-Segment Depression in Coronary Heart Disease
Authors: JEAN-MARIE DETRY, ROBERT A. BRUCE
Journal: Circulation (1971)

Symptom-limited maximal oxygen intake (V O O2 S-L ) and electrocardiographic responses to multistage treadmill test were determined before and after 3 months of physical training in 14 patients with coronary heart disease. Six patients also had hemodynamic studies done at several submaximal work loads in the upright position before and after training. S-T-segment responses were measured by computer averaging of 100-beat samples. After physical training, the heart rate ( P &lt; 0.01) and the product of heart rate and systolic blood pressure ( P &lt; 0.02) at submaximal exercise were lower and attended by significantly less S-T-segment depression. At maximal exercise, however, the heart rate ( P &lt; 0.01) and the product of heart rate and systolic blood pressure ( P &lt; 0.02) were higher after training, and the S-T-segment depression was more pronounced ( P &lt; 0.005). The quantitative relationships of S-T-segment depression to either exercise heart rate, product of heart rate and systolic blood pressure, or to pressure-rate product (product of heart rate and mean blood pressure) were unaffected by physical training. The V O O2 S-L increased by 20.8% ( P &lt; 0.001); the product of heart rate and systolic blood pressure at symptom-limited exercise increased by 10% ( P &lt; 0.005) in the angina patients, which may indicate a higher angina threshold after physical training. It is concluded that physical training of coronary patients changes S-T-segment responses to submaximal and maximal exercise: these modifications presumably result from changes in heart-rate and blood-pressure responses to exercise, rather than from an improved coronary circulation.
SALPINGITLS; WITH A REPORT OF TWO CASES.Read at the Forty-sixth Annual Meeting of the Ohio State Medical Society, Sandusky, O., June 17, l8, 19, 1891.
Authors: A. B. WALKER
Journal: JAMA (1891)

It has been but a few years since we have known much regarding diseases of the Fallopian tubes. Thirty-three years ago Bernutz, in his writings, clearly described the pathology of pelvic inflammations. But little advance, however, was made until Mr. Lawson Tait, in 1872, made known his remarkable success in removing diseased tubes by laparotomy.  The writings of Battey, in America, and Hegar, in Germany, on the removal of ovaries for other diseases than that of ovarian tumors had much influence in developing the proper method in treating diseases of the uterine appendages.  It was hot until 1882-3 in America that the operation of laparotomy was made for removal of diseased tubes, the first operator being W. Gill Wylie, of New York.  During the years 1883-4 numerous cases were operated upon for salpingitis by gyecologists and surgeons, since which time the operation has been very frequently performed.  Previous to the
Levodopa and Chronic Bronchitis
Authors: M. Sandler
Journal: BMJ (1974)

bilirubinemia in the newborn, as has been suggested.5Finally, practically nothing is known.about the influence of diazepam upon the developing fetal brain or the developing neurological functions of the newborn.Thus we do not reconmnend the subchronic use of diazepam in any stage of pregnancy or in doses higher than 10-20 mg to the mother during labour.-Weare, etc.,
Atlas of Nuclear Medicine, vol 2: Lung and Heart
Authors: James L. Quinn
Journal: JAMA (1971)

Lung and heart scanning have been accepted as valuable diagnostic procedures in a variety of diseases. The lung scan is very sensitive in depicting pulmonary perfusion. Since many diseases alter perfusion, the nonspecificity of the test leads to diagnostic confusion. This atlas tries to unscramble some of these problems through careful attention to patterns and specific locations of abnormal perfusion. The book is divided into sections on lung, radioangiocardiography, heart blood pool, and myocardial scanning. The greatest emphasis is placed on the use of the lung scan in cases of pulmonary embolism. The distribution of radioactivity in relation to the segmental anatomy of the lung is stressed. However, there is no mention of the lower lobe medial basal segments. There are many fine illustrations of segmental perfusion defects, but it was often difficult to concur with the authors' specific locations. This was compounded by their use of an anterior anatomic
Photodynamic therapy-mediated modulation of inflammatory cytokine production by Epstein–Barr virus-infected nasopharyngeal carcinoma cells
Authors: Ho-Kee Koon, Kwok-Wai Lo, Kwok-Nam Leung, Maria Li Lung, Chris Chi-Kwong Chang, Ricky Ngok-Shun Wong, Wing-Nang Leung, Nai-Ki Mak
Journal: Cellular and Molecular Immunology (2010)
EXCESSIVELY HIGH TEMPERATURE IN A CASE OF INCIPIENT PULMONARY TUBERCULOSIS
Authors: O. H. BROWN
Journal: JAMA (1910)

The patient in this case was in the Missouri State Sanatorium for from twelve to fourteen months. One morning, a year or more ago, the nurse brought a thermometer to me complaining that she could not tell where it registered. She said that this happened every time she shook the mercury down and returned the thermometer to the mouth of this particular patient. The nurse also complained that the patient had bitten the bulb off from one or two thermometers. On examining, I found that the mercury extended nearly to the free end of the thermometer. I was aware that a patient sometimes plays a trick on the nurse by holding the mercury bulb in the steam-jet of the radiator, so I took the thermometer and placed it in the patient's mouth and stayed by her side. Soon the patient complained that the thermometer bulb was broken in her mouth.
They don't train 'em like they used to
Authors: J. S Taylor, S. Nicholson
Journal: BMJ (2008)

<h3>Abstract</h3> Oxidative stress and neuroinflammation play a central role in Alzheimer’s Disease (AD) pathogenesis. However, the mechanism by which these processes lead to neurodegeneration is still not fully understood. Thioredoxin-1 (Trx1) is an antioxidant protein that can be cleaved into a peptide known as Thioredoxin-80 (Trx80), which modulates monocyte function in the periphery and shows anti-amyloidogenic properties in the brain. In this study we aimed to further clarify the biological function of this peptide and its regulation in the brain. We show that neurons are the main producers of Trx80 in the brain. Trx80 levels increase <i>in vivo</i> both in normal aging and in young APP<sup><i>NL-G-F</i></sup> mouse model of amyloid pathology. Trx80 levels were increased in neurons in primary culture treated with either rotenone or 27-hydroxycholesterol, what suggests that Trx80 production is stimulated upon oxidative stress. RNA-sequencing followed by differential gene expression analysis revealed that Trx80 induces microglia activation into a phenotype compatible with interferon response microglia. Finally, we determine that the induction of this microglia phenotype by Trx80 is Trem2-dependent. This study identifies Trx80 as a novel neuron-derived signaling mechanism that modulates microglia function under stress conditions. Strategies to regulate Trx80 levels could be beneficial against AD pathology.
Avoiding the Ciprofloxacin-Didanosine Interaction
Authors: Jan Sahai
Journal: Annals of Internal Medicine (1995)

Letters1 September 1995Avoiding the Ciprofloxacin-Didanosine InteractionJan Sahai, PharmDJan Sahai, PharmDOttawa General Hospital; Ottawa, Ontario K1H 8L6; CanadaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-5-199509010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Because of multiple drug allergies and the emergence of drug-resistant mycobacterial infections, the fluoroquinolones are widely used in patients with human immunodeficiency virus infection. The absorption of ciprofloxacin is dramatically reduced when it is coadministered with didanosine [1]. The interaction is caused by complexation between the magnesium and aluminum cations and the ciprofloxacin molecule, which results in the formation of a nonabsorbable complex. Standard references and the package insert for recommendations for avoiding this interaction suggest separating the dosing schedules of the agents by 2 hours [2-4]. This suggestion is clearly incorrect. Nix and colleagues [5] have ...References1. Sahai J. Gallicano K, Oliveras L, Khaliq S, Hawley-Foss N, Garber G. Cations in the didanosine tablet reduce ciprofloxacin bioavailability. Clin Pharmacol Ther. 1993; 53:292-7. Google Scholar2. American Hospital Formulary Service (AHFS) Drug Information. Bethesda, MD: American Society of Hospital Pharmacists; 1995:424. Google Scholar3. Compendium of Pharmaceuticals and Specialties. Ottawa, Ontario: Canadian Pharmaceutical Association; 1995:1472. Google Scholar4. Didanosine (Videx) package insert. Princeton, NJ: Bristol-Myers Squibb, Inc. Google Scholar5. Nix DE, Watson WA, Lener ME, et al. Effects of aluminum and magnesium antacids and ranitidine on the absorption of ciprofloxacin. Clin Pharmacol Ther. 1989; 46:700-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Jan Sahai, PharmDAffiliations: Ottawa General Hospital; Ottawa, Ontario K1H 8L6; Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAIDS/HIV: Drugs for Opportunistic InfectionsClinical PharmacologyManagement of Drug Interactions in Patients with HIV 1 September 1995Volume 123, Issue 5Page: 394-395KeywordsAllergy and immunologyAttentionBloodBlood plasmaCationsDrug interactionsDrugsHIVMagnesiumMinimum inhibitory concentration ePublished: 15 August 2000 Issue Published: 1 September 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
1003-92 Relationship between acute hyperglycemia and microvascular injury after primary coronary angioplasty for acute myocardial infarction
Authors: Takefumi Takahashi, Yoshikazu Hiasa, Takeshi Tomokane, Koji Yamaguchi, Riyo Ogura, Hitoshi Miyajima, Yoshikazu Ohara, Tatsuro Ogata, Kenichiro Yuba, Naoki Suzuki, Shinobu Hosokawa, Koichi Kishi, Ryuji Ohtani
Journal: Journal of the American College of Cardiology (2004)
Venous blebs on the toes in type IV Ehlers-Danlos syndrome
Authors: None Neelam, None Charles-Holmes, None Pope
Journal: British Journal of Dermatology (1999)

Journal Article Venous blebs on the toes in type IV Ehlers–Danlos syndrome Get access Neelam, Neelam Department of Dermatology, Warwick Hospital, Warwick CV34 5BW, U.K. Search for other works by this author on: Oxford Academic Google Scholar Charles‐Holmes, Charles‐Holmes Department of Dermatology, Warwick Hospital, Warwick CV34 5BW, U.K. Search for other works by this author on: Oxford Academic Google Scholar Pope Pope Institute of Medical Genetics, University of Wales College of Medicine, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 140, Issue 3, 1 March 1999, Pages 543–544, https://doi.org/10.1046/j.1365-2133.1999.02730.x Published: 01 March 1999
Herpes gestationis and anti-HLA immunization
Authors: E. EBERST, M.M. TONGIO, B. EBERST, S. MAYER, A. BASSET
Journal: British Journal of Dermatology (1981)

The lymphocytotoxicity technique at +15°C and +37°C was used to identify anti‐HLA and cold lymphocytotoxic antibodies in sera from two women with herpes gestationis. The degree of severity of the illness was different in the two cases. The more serious case (widespread cutaneous involvement, repeated fetal deaths) had a very powerful anti‐HLA‐A9+anti‐HLA‐B5 antibody (titre 1/1000); the other had Icss severe skin lesions; she had an anti‐HLA‐B13 antibody (titre was 1/256). Both cases had cold lymphocytotoxic auto‐antibodies.
Characterizaiton of two populations of human lymphocytes bearing easily detectable surface immunoglobulin.
Authors: D A Horwitz, P I Lobo
Journal: Journal of Clinical Investigation (1975)

Two separate lymphocyte populations, each bearing easily detectable surface immunoglobulin, have been detected in human peripheral blood. The first, B cells, has surface determinants that are stable at 37degreeC, but are removed by pronase and regenerate in culture. The cells are nylon adherent and have a receptor for C3, and studies with unit gravity sedimentation indicate they are mostly small lymphocytes. B cells comprise 9.5% of the total lymphocytes, with the normal range from 3-16%. As many or more lymphocytes lack membrane-incorporated Ig determinants but have an Fc receptor that binds IgG1 and IgG3 in normal serum maximally at 4degreeC. This receptor for cytophilic IgG is removed by pronase but not by trypsin. The second population has been named L lymphocytes because of membrane-labile IgG determinants. L cells do not adhere to nylon, do not form rosettes with sheep erythrocytes sensitized with antibody and mouse complement, and are larger than small lymphocytes. These lymphocytes with cold-reactive Fc receptors for serum IgG do not form E-rosettes or respond to phytohemaggutinin. Since L cells do not have surface markers of T and B lymphocytes, it is likely that they comprise a separate population.
Persistent Low Back Pain
Authors: Eugene J. Carragee
Journal: New England Journal of Medicine (2005)

A 49-year-old maintenance worker with a history of depression and previous reports of minor back pain is seen during four months of continuing low back pain. He has remained out of work for fear of worsening the injury. Magnetic resonance imaging two weeks after the onset of pain showed only mild degenerative changes in the lumbar region without spinal stenosis or disk collapse or extrusion. How should this patient be evaluated and treated?
ORAL CONTRACEPTION AND VENOUS THROMBOSIS
Authors: Edward T. Tyler
Journal: JAMA (1963)

Between 1961 and 1963 there were 347 instances of thrombophlebitis in women using a norethynodrel-estrogen combination (Enovid) for contraception reported to the manufacturer. Fatal pulmonary embolism occurred in 35 cases, of which 9 were due to causes other than Enovid. There is a serious lack of reliable statistics concerning the occurrence of thrombophlebitis or pulmonary embolism in the female population at various ages. A meeting of specialists in 1962 concluded that no evidence was available to relate spontaneous intravascular clotting with the use of oral contraceptives. Supporters of a simple contraceptive maintain that if Enovid is responsible for the problems noted, the incidence is extremely low and would probably be consistent with the rare-drug idiosyncrasy or sensitivity. There would be a greater health risk to those women who, through nonuse of any contraceptives (when they would have used the oral method), become pregnant and develop thromboembolism as a consequence of pregnancy.
Closure of Coronary Arteriotomy in the Dog by Means of an Autogenous Arterial Patch
Authors: KHAGENDRA N. CHATTERJEE, RICHARD WARREN
Journal: Circulation (1963)

A simple technique of application of a patch graft to a coronary arteriotomy without using a cardiopulmonary bypass is described. Twelve dogs were subjected to this procedure, the circumflex coronary artery being used in eight, and the left anterior descending coronary artery in four. A 66 per cent patency of the segment was obtained. In one dog, a coronary arteriogram showed a patent segment six months later. Histological study revealed some intimal thickening of the patch, as well as of the host artery. Gross myocardial infarction was observed in those with occluded segments.
Seasonal Variations in Urinary Excretion of Calcium
Authors: W. G. Robertson, J. C. Gallagher, D. H. Marshall, M. Peacock, B. E. C. Nordin
Journal: BMJ (1974)

A retrospective study over a three-year period has shown a noticeable seasonal variation in the daily urinary excretion of calcium in healthy men, healthy women, and men prone to form stones. This reached a maximum in July or August and a minimum in December or January in all three groups. For any given month the stone formers had higher urinary calcium values than healthy men, who, in turn, had higher values than healthy women.
Polymyositis, not polymyalgia rheumatica.
Authors: N D Hopkinson, D J Shawe, J M Gumpel
Journal: Annals of the Rheumatic Diseases (1991)

The distinction between polymyalgia rheumatica and polymyositis is important for treatment and prognosis. Four elderly patients were diagnosed and treated for polymyalgia: raised creatine kinase led to muscle biopsy and a diagnosis of polymyositis.
Patency of Percutaneous Transluminal Coronary Angioplasty Sites at 6-Month Angiographic Follow-Up
Authors: Eric Van Belle, Régis Ketelers, Christophe Bauters, Marc Périé, Kaveh Abolmaali, Florence Richard, Jean-Marc Lablanche, Eugène P. McFadden, Michel E. Bertrand
Journal: Circulation (2001)

Background —Several reports have demonstrated a high mortality rate in diabetic patients treated by standard coronary balloon angioplasty. No clear explanation has been provided for this finding. Methods and Results —Consecutive diabetic patients successfully treated by standard coronary balloon angioplasty (n=604) were enrolled in a follow-up program including repeated angiography at 6 months and long-term clinical follow-up. Clinical follow-up was available in 603 patients (99.8%). Twelve patients died, 2 underwent bypass surgery before scheduled repeated angiography, and 76 declined angiography. Determinants of long-term mortality were analyzed in the 513 patients with angiography at 6 months and long-term clinical follow-up (mean follow-up, 6.5±2.4 years). On the basis of the results of repeated angiography, 3 groups of patients were defined: group 1, 162 patients without restenosis (32%); group 2, 257 patients with nonocclusive restenosis (50%); and group 3, 94 patients with coronary occlusion (18%). Overall actuarial 10-year mortality rate was 36%. Actuarial 10-year mortality was 24% in group 1, 35% in group 2, and 59% in group 3 ( P &lt;0.0001). Multivariate analysis demonstrated that coronary occlusion was a strong and independent correlate of long-term total mortality (hazard ratio, 2.16; 95% CI, 1.43 to 3.26; P =0.0003) and cardiac mortality (hazard ratio, 2.38; 95% CI, 1.48 to 3.85; P =0.0004). Conclusions —This study demonstrates that restenosis, especially in its occlusive form, is a major determinant of long-term mortality in diabetic patients after coronary balloon angioplasty.
ON SPECIFIC INHIBITION OF BACTERIOPHAGE ACTION BY BACTERIAL EXTRACTS
Authors: Philip Levine, A. W. Frisch
Journal: The Journal of Experimental Medicine (1934)

1. Experiments are presented demonstrating specific inhibition of phage by soluble products of bacteria. 2. The inhibition proceeds more rapidly when the phage and bacterial extracts are incubated at 37 degrees than at ice box temperature. 3. The specificity of the reaction in the instances studied is probably connected with the presence of specific soluble carbohydrates. 4. A reaction is available for the study of the chemistry of bacillary antigens in terms of bacteriophage.