Ethchlorvynol (Placidyl®) Intoxication
Authors: FREDERIC B. WESTERVELT
Journal: Annals of Internal Medicine (1966)

Article1 June 1966Ethchlorvynol (Placidyl®) IntoxicationExperience with Five Patients, Including Treatment with HemodialysisFREDERIC B. WESTERVELT JR., M.D.FREDERIC B. WESTERVELT JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1229 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe self-administered overdose of hypnotic-sedative drugs has long been a popular means of expressing situational protest and, not infrequently, accomplishing an intended suicidal act. While the barbiturates have been the agents most frequently used, the recent efforts of the pharmaceutical industry to provide the ideal hypnotic agent have made available an ever-increasing number of compounds to the suicide-bent. These, added to the long list of ataractic agents, make the diagnostic and the therapeutic tasks of the clinical toxicologist a trying one, indeed.Ethchlorvynol (Placidyl®), introduced in 1955, has achieved remarkably little notoriety in this regard. Consequently, we know little concerning...References1. ALGERIKATSASLUONGO EJGGMA: Determination of ethchlorvynol in biologic mediums, and report of two fatal cases. Amer. J. Clin. Path. 38: 125, 1962. CrossrefMedlineGoogle Scholar2. WOLFKEMPKILEYCURRIE AVDGJEGD: Artificial kidney function: kinetics of hemodialysis. J. Clin. Invest. 30: 1062, 1951. CrossrefMedlineGoogle Scholar3. MAHERSCHREINERWESTERVELT JFGEFB: Acute gluthetimide intoxication. I. Clinical experience (twenty-two patients) compared to acute barbiturate intoxication (sixty-three patients). Amer. J. Med. 33: 70, 1962. CrossrefMedlineGoogle Scholar4. WESTERVELT FB: Ethchlorvynol: its toxicity and in vitro dialysance (abstract). Clin. Res. 13: 55, 1965. Google Scholar5. 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FLANIGANHENDERSONMERRILL WJLWJP: The clinical application and technique of peritoneal dialysis. GP 28: 98, 1963. MedlineGoogle Scholar13. SCHREINER GE: The role of hemodialysis (artificial kidney) in acute poisoning. Arch. Intern. Med. (Chicago) 102: 896, 1958. CrossrefGoogle Scholar14. MAHERSCHREINER JFGE: Hazards and complications of hemodialysis. New Eng. J. Med. 273: 370, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FREDERIC B. WESTERVELTJR., M.D.Affiliations: Charlottesville, VirginiaFrom the Renal Section, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Va.Requests for reprints should be addressed to Frederic B. Westervelt, Jr., M.D., Box 229, University of Virginia Hospital, Charlottesville, Va. 22901. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBarbituriques et autres hypnotiques et sédatifsBarbiturates and Other Hypnotics and SedativesEthchlorvynol overdoseThe effects of totigestational exposure to ethchlorvynol on development and behaviorA death due to ethchlorvynol abuse. A case reportResin Hemoperfusion for EthchlorvynolNEAL L. BENOWITZ, M.D., JON ROSENBERG, M.D., SUSAN POND, M.D.Resin hemoperfusion in dogs intoxicated with ethchlorvynol (Placidyl®)Resin Hemoperfusion for Treatment of Ethchlorvynol OverdoseROBERT I. LYNN, M.D., CHRISTINE L. HONIG, M.D., PETER I. JATLOW, M.D., ALAN S. KLIGER, M.D.Ethchlorvynol (Placidyl⌖)-Induced Pulmonary EdemaFREDERICK L. GLAUSER, M.D., WILLIAM RICHARD SMITH, M.D., ALEX CALDWELL, M.D., MELVIN HOSHIKO, M.D., GEOFFREY S. DOLAN, M.D., HAROLD BAER, M.D., NEAL OLSHER, M.D.Hemolysis and Pancytopenia in Ethchlorvynol OverdoseJOHN C. KLOCK, M.D.Ethchlorvynol in biological fluids: Specificity of assay methodsEthchlorvynol (“Placidyl”): Determination in Serum and UrineDialysis of Poisons and DrugsExtracorporeal and Peritoneal Dialysis of DrugsAcute Ethchlorvynol (Placidyl®) IntoxicationBRENDAN P. TEEHAN, M.D., JOHN F. MAHER, M.D., F.A.C.P., JAMES J. H. CAREY, M.D., PAULINE D. FLYNN, B.S., GEORGE E. SCHREINER, M.D., F.A.C.P.Ethchlorvynol IntoxicationON SPECIAL TRAITS OF ACUTE ETHCHLORVYNOL POISONING 1 June 1966Volume 64, Issue 6Page: 1229-1236KeywordsAddictionAttentionComaGratitudeHypotensionIngestionIntoxicationResearch laboratories ePublished: 1 December 2008 Issue Published: 1 June 1966 PDF downloadLoading ...