tbuckley/cabot-search huggingface dataset:
Squire's Fundamentals of Radiology
Authors: J. W. Berlin
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Critical Analysis of RBRVS-Reply
Authors: James V. Maloney
Journal: JAMA (1992)

<h3>In Reply.</h3> —Each of the letters makes, in different ways, two points. First, physicians are uncomfortable with the implications of using reimbursement rates per hour for different putative skill levels—I agree. The lawyers were also uneasy until the Supreme Court (<i>Goldfarb vs Fairfax County Bar Association</i>) found that fee schedules in the learned professions violated antitrust law. My lawyer has since charged for time to the nearest 0.1 hour at rates varying from $150 per hour for junior associates to $300 for senior partners. The second is that the data of others used in the study are poor. I agree that the Mendenhall study (the only available) was elegantly done, but it is 15 years old. The HCFA spent $100 million in 3 months to revise the computer software used by regional medicare carriers to implement the latest fee schedule. Could not $250 000 be spent to learn if the
Reducing risks in sudden infant death syndrome.
Authors: D. Keeley
Journal: BMJ (1992)

by the authors are prerequisites for any major collaborative audit, and the enthusiasm with which general practitioners in Manchester have accepted the task of improving their standards in the care of diabetes, in collaboration with consultant colleagues, suggests great achievements ahead.We have similar schemes for antenatal care, hypertension, and radiology as well as for facilitating audit in individual practices.Of course, as the authors identified, this work raises educational needs, and we are addressing these.My argument with Berwick and colleagues is that, in the longer term, quality and outcomes as assessed by patients will be seen as clear objectives and that formal audit, though the main tool, may not be all that medical audit advisory groups find themselves asked to do.Already practices are asking for help with organisation and management as well as audit.Perhaps by the end of the decade we shall be restyling ourselves medical quality management groups.
Hemodynamic, fluid, and electrolyte changes in sodium-depleted, one-kidney, renal hypertensive dogs.
Authors: G A Stephens, J O Davis, R H Freeman, J M DeForrest, D M Early
Journal: Circulation Research (1979)

We evaluated the role of increased cardiac output in the development of experimental renal hypertension.The studies were made in five uninephrectomized, sodium-depleted dogs; renal blood flow was reduced by 55-00% by renal artery constriction (RAC).Blood pressure (BP), plasma renin activity (PRA), heart rate (HR), cardiac output (CO), stroke volume (SV), and plasma volume (PV) were determined in conscious dogs before and on days 2, 4, 6, 10, 14, 21, and 28 after RAC.After RAC, BP increased from a control mean value of 96 mm Hg to 118-147 mm Hg.CO fell from a control mean value of 1.92 liters/min to 1.42 and 1.63 liters/min (P < 0.05) on days 2 and 4 after RAC.After four days of RAC, CO was not significantly different from the control mean value.During hypertension, HR was consistently lower than the control mean value of 94 beats/min.Water balance was positive on days 1 and 4, but no change in PV was detected.During the control period, PRA was elevated ft-to 8fold above sodium replete values.After RAC, PRA increased transiently on days 2 and 4 and then returned to the high sodium-depleted level.Three of the five dogs were sodium repleted 28 days after RAC; arterial pressure was unchanged but CO increased, peripheral resistance fell, and PRA returned to the normal level.The results demonstrate that sodium retention and a consequent increase in cardiac output were unnecessary for the development of one-kidney experimental renal hypertension.Also, the level of chronic hypertension was unaffected by sodium and volume repletion.
COMPLETE OCCLUSION OF BOWEL.
Authors: DWIGHT E. CONE
Journal: JAMA (1900)

Nov. 2, 1899, I saw Mrs. A. B. R., of Greene, N. Y., in consultation with Dr. Williams of that town, who gave the following history: An American, aged 63, her family history was good. She had been married for forty-five years and had one child forty-two years ago. She had been troubled with what she called "bilious" attacks ever since she could remember. About thirty-five years ago she had a very severe illness which was described as inflammation of the bowels and, though "given up" to die, she gradually recovered. Since that time her troubles with her stomach, or "bilious attacks," have been more or less constant. On September 4, last, she was attacked with vomiting and free purging, and after a week felt some better. In a few days there was another and one week later a third attack lasting about one week, after which there was no
Hyperbilirubinemia and High-Density Lipoprotein Cholesterol
Authors: AMIN A. NANJI
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 November 1982Hyperbilirubinemia and High-Density Lipoprotein CholesterolAMIN A. NANJI, M.D., SUSEELA REDDY, M.D.AMIN A. NANJI, M.D.Search for more papers by this author, SUSEELA REDDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-5-786_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Slight elevations in unconjugated serum bilirubin have been reported in a large number of patients and occur in 0. 5% to 7.0% of the population (1). Most patients are unaware of this abnormality until hyperbilirubinemia is detected on incidental laboratory examination(2). Because fasting increases serum bilirubin levels (3), the incidence of this abnormality may be higher after an overnight fast. In a screening study of apparently healthy men (from 35 to 55 years old), we found 21 men with fasting serum bilirubin levels above the upper limit of the normal range (N, 0.4 to 1.0 mg/dL) (range...References1. SCHMIDMcDONAGH RA. Hyperbilirubinemia. In: STANBURY JB, WYNGAARDEN JB, FREDRICKSON DS. Metabolic Basis of Inherited Disease. New York: McGraw Hill; 1978:1221-57. Google Scholar2. FOULKBUTTOWENWHITCOMBMASON WHCFH. Constitutional hepatic dysfunction (Gilbert's disease): its natural history and related syndromes. Medicine. 1959;38:25-37. CrossrefMedlineGoogle Scholar3. BLOOMERBARRETTRODKEYBERLIN JPFN. Studies on the mechanism of fasting hyperbilirubinemia. Gastroenterology. 1971;61:479-87. CrossrefMedlineGoogle Scholar4. DAVIDSONROJAS-BUENOTHOMPSONWILLIAMS AARR. Reduced caloric intake and nicotinic acid provocation tests in the diagnosis of Gilberts syndrome. Br Med J. 1975;2:480. CrossrefMedlineGoogle Scholar5. WILSONLEES DR. Metabolic relationships among the plasma lipoproteins: reciprocal changes in the concentrations of very low and low density lipoproteins in man. J Clin Invest. 1972;51:1051-7. CrossrefMedlineGoogle Scholar6. SHEPHERD J. The influence of polyunsaturated fat diets and nicotinic acid therapy on the metabolism and subfraction distribution of human high density lipoproteins. In: GOTTO AM, MILLER NE, OLIVER MF, eds. High Density Lipoproteins. Amsterdam: Elsevier; 1978:193-206. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of British Columbia Metropolitan Laboratories Vancouver, British Columbia Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1982Volume 97, Issue 5Page: 786-786KeywordsBilirubinHigh density lipoprotein cholesterolResearch laboratories Issue Published: 1 November 1982 PDF DownloadLoading ...
TAKING P VALUES OUT OF SALES TALK
Authors: J.L. Burton
Journal: British Journal of Dermatology (1975)

Journal Article TAKING P VALUES OUT OF SALES TALK Get access J.L. Burton J.L. Burton Dermatology Department, Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 3, 1 March 1975, Page 359, https://doi.org/10.1111/j.1365-2133.1975.tb03092.x Published: 01 March 1975
Robin Miller-Catchpole, MD
Authors: William R. Hendee
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Flow cytometric DNA analysis of classic and steroid-induced Kaposi's sarcoma
Authors: Z. REIZIS, A. TRATTNER, V. KATZENELSON, M. DAVID, A. ROTEM, O. NATIV, Y. MOR
Journal: British Journal of Dermatology (2006)

Summary Flow cytometric DNA analysis of various tumours has indicated a correlation between the degree of malignancy and ploidy; results which could have clinical significance. We analysed the ploidy of Kaposi's sarcoma (KS) tumours, and classified the results according to clinical history and histological findings. We found that patients on steroid treatment had an aneuploid pattern, and most of the patients with classic-type KS had a diploid pattern on flow cytometry.
A double‐blind comparison of nasal budesonide and oral astemizole for the treatment of perennial rhinitis
Authors: C. Bunnag, P. Jareoncharsri, E. C. K. Wong
Journal: Allergy (1992)

Sixty‐nine outpatients with symptomatic perennial rhinitis were recruited to this double‐blind, parallel‐group study to compare budesonide nasal spray with oral astemizole. Following a 1‐week run‐in on placebo, 67 patients achieved a mean daily total symptom score of at least 4 (scoring for each symptom was 0 = none, 1 = mild, 2 = moderate, 3 = severe), and were randomized to study treatments ‐ 33 to budesonide, 100 ug in each nostril morning and evening, and 34 to astemizole, one 10‐mg tablet each morning, for a period of 4 weeks. No antihistamine preparations other than eye drops and no corticosteroids were permitted during the active treatment period. Patients recorded symptoms of blocked nose, runny nose, sneezing, itchy nose, sore eyes or runny eyes in diary cards each evening before retiring. Diary card data showed that there was significantly greater improvement in blocked nose, runny nose and runny eyes during the first 2 weeks of budesonide treatment than during the same period on astemizole. A similar, although non‐significant, trend was observed for sneezing and itchy nose, but there was no apparent difference in the reporting of sore eyes. After 4 weeks, blocked nose and runny nose remained significantly less troublesome in the budesonide group. Both treatments were well‐tolerated and no major adverse effects were reported. Patient ratings for treatment efficacy were significantly higher for budesonide than astemizole at both 2 weeks and 4 weeks.
Organochlorines in breast milk from two cities in Ukraine.
Authors: B C Gladen, S C Monaghan, E M Lukyanova, O P Hulchiy, Z A Shkyryak-Nyzhnyk, J L Sericano, R E Little
Journal: Environmental Health Perspectives (1999)

Reports of environmental problems in the former Soviet Union, including excess use of pesticides, have led to concerns about high levels of contamination in humans, but little information is available to assess whether these concerns are warranted. Samples of breast milk from 197 women from two cities in Ukraine were analyzed for p,p'-DDT, p,p'-DDE, endrin, dieldrin, heptachlor epoxide, trans-nonachlor, oxychlordane, hexachlorobenzene, ss-hexachlorocyclohexane (HCH), and 18 polychlorinated biphenyl congeners, and results were compared to previous reports from Europe. The median ss-HCH concentration was 731 ng/g milk fat, which is higher than other reports from Europe but lower than reports from other parts of the world. The median DDE concentration was 2,457 ng/g milk fat, which is higher than most but not all other reports from Europe. Concentrations of other chemicals were comparable to or lower than other reports from Europe. Concentrations from the city of Kyiv were generally lower than those from Dniprodzerzhinsk, but the magnitudes of these differences were modest.
Determination of left ventricular mass in dogs with rapid-acquisition cardiac computed tomographic scanning.
Authors: A J Feiring, J A Rumberger, S J Reiter, D J Skorton, S M Collins, M J Lipton, C B Higgins, S Ell, M L Marcus
Journal: Circulation (1985)

The development of left ventricular hypertrophy in patients with heart disease often has far-reaching clinical implications with respect to overall morbidity and mortality. Approaches used to assess left ventricular mass include electrocardiography, echocardiography, contrast ventriculography, single photon-emission tomography, and conventional computed tomography. However, all of these modalities suffer from some major draw back that precludes widespread application to all patients. In this study we assessed the accuracy of determinations of left ventricular mass in 22 dogs by rapid-acquisition (50 msec) computed axial tomography (RACAT), an ultrafast computed tomographic (CT) instrument. Electrocardiographically triggered, end-diastolic, short-axis cardiac scans were obtained from apex to base during administration of intravenous iodinated contrast. Myocardial edges were determined for each tomographic scan by two methods: the regional half-contour method (the CT density half way between that of the left ventricular myocardium and adjacent ventricular cavities or lung) and "interactive plateau thresholding" of the cardiac borders. Left ventricular mass by RACAT was calculated as the sum of the mass of each individual scan from apex to base (modified Simpson's rule). Postmortem left ventricular mass ranged from 58 to 160 g. The correlation between true left ventricular mass and tomographically determined mass was excellent (r = .99), with the slope and y intercept not statistically different from 1 and 0, respectively. The standard error of the estimate was 4.1 g. Interobserver and intraobserver variability for determining left ventricular mass demonstrated excellent agreement (r = .99 and r = .99, respectively). We conclude that quantitative assessment of left ventricular mass can be accurately and reproducibly performed in dogs by rapid acquisition CT scanning. It is likely that this technique will be readily transferable to the clinical settings and prove to be an important method for quantifying left ventricular mass in patients.
Abstract 500: Role of R-spondin4 in Wnt/β-catenin signaling and cell proliferation in breast cancer.
Authors: Wenyan Lu, Cuihong Lin, Taj K. King, Yonghe Li
Journal: Cancer Research (2013)

Abstract R-spondin 4 (Rspo4) is a member of the Rspo protein family, which is another group of secreted proteins that can activate Wnt/β-catenin signaling. Although it is well recognized that Wnt/β-catenin signaling is important for breast cancer development and progression, the role of Rspo4 in breast cancer is unclear. In the present study, we found that Rspo4 was expressed in breast cancer cell lines, but absent in normal mammary epithelial cells (HMECs). We also found that Rspo4 expression was up-regulated in human malignant breast tissues. Moreover, Rspo4 acted synergistically with Wnt3A to activate Wnt/β-catenin signaling in breast cancer cells. Conversely, reducing endogenous Rspo4 with siRNAs in human breast cancer cell lines suppressed Wnt/β-catenin signaling and cell proliferation. These data suggest that Rspo4 functions as a positive regulator of breast cancer proliferation by activating Wnt/β-catenin signaling. Citation Format: Wenyan Lu, Cuihong Lin, Taj K. King, Yonghe Li. Role of R-spondin4 in Wnt/β-catenin signaling and cell proliferation in breast cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 500. doi:10.1158/1538-7445.AM2013-500
Serum From Patients With Severe Heart Failure Downregulates eNOS and Is Proapoptotic
Authors: Laura Agnoletti, Salvatore Curello, Tiziana Bachetti, Fabio Malacarne, Giuseppina Gaia, Laura Comini, Maurizio Volterrani, Paolo Bonetti, Giovanni Parrinello, Moris Cadei, Pier Giovanni Grigolato, Roberto Ferrari
Journal: Circulation (1999)

Background —Cytokine activation and endothelial dysfunction are typical phenomena of congestive heart failure (CHF). We tested the hypothesis that incubating human umbilical vein endothelial cells with serum from patients with CHF will downregulate endothelial constitutive nitric oxide synthase (eNOS) and induce apoptosis. Methods and Results —We studied 21 patients with severe CHF. Levels of tumor necrosis factor-α (TNF-α) and several neuroendocrine parameters were assessed. eNOS was measured by Western Blot analysis and apoptosis by optical microscopy and flow cytometry. We observed (1) eNOS downregulation (difference versus healthy subjects at 24 hours [ P &lt;0.05] and 48 hours [ P &lt;0.001]), (2) nuclear morphological changes typical of apoptosis; and (3) a high apoptotic rate with propidium iodide (increasing from 2.1±0.4% to 11.3±1.2% at 48 hours; P &lt;0.001 versus healthy subjects) and annexin V. An anti-human TNF-α antibody did not completely counteract these effects. A strong correlation existed between eNOS downregulation and apoptosis ( r =−0.89; P &lt;0.001). Conclusions —Serum from patients with severe CHF downregulates eNOS expression and increases apoptosis. High levels of TNF-α likely play a role, but they cannot be the only factor responsible.
The global response to mental illness
Authors: Graham Thornicroft, Samantha Maingay
Journal: BMJ (2002)

The scale of the global challenge posed by mental illness has become increasingly clear in recent years.1 The inadequacy of our international response is only now apparent with the publication of three ground breaking reports from the World Health Organization.

We know that about a tenth of adults, an estimated 450 million people worldwide, are affected by mental disorders at any one time. They now account for about 12.3% of the global burden of disease,2 and this will rise to 15% by the year 2020.3 For disability alone, without the effects of premature mortality, the impact of neuropsychiatric conditions is starker still: they account for 31% of all years lived with disability. Such averages conceal substantial global variations. In Europe and the Americas, for example, these conditions now make up 43% of the total burden of disability.2

How far is our response commensurate with these challenges? The WHO has just published the …
Preventing children drowning
Authors: S. Kilpatrick, S. Kilpatrick
Journal: BMJ (1992)

Preventing children drowning SIR,-Three summers ago our 2 year old son wandered from our garden.He was found in the swimming pool of a neighbouring garden: the pool was unfenced and had a non-weightsbearing cover.Resuscitation was not successful.We know of three families within 16 km who have suffered similar tragedies: as Alison Kemp and J R Sibert point out, drowning is a common cause of acci- dental death in children.'In our society, where there is increased emphasis on out ofdoors activities, the incidence ofdrowning in children will surely increase unless effective preventive measures are taken.We have written on this matter to our member of parliament without success.We support Kemp and Sibert's recom- mendations that domestic pools should have toddler proof fences with self locking doors and covers that can bear the weight of a child.People may argue that this interferes with personal liberty: the same was said about seat belt legislation.The children whose lives are at risk are too young to appreciate such abstract arguments.
Erythroderma due to etretinate
Authors: Jeremy Levin, John Almeyda
Journal: British Journal of Dermatology (1985)

Journal Article Erythroderma due to etretinate Get access Jeremy Levin, Jeremy Levin Department of Internal Medicine, University of Geneva, Hopital Cantonal, Geneva 1205, Switzerland Search for other works by this author on: Oxford Academic Google Scholar John Almeyda John Almeyda North Middlesex Hospital, Edmonton, London N18 1QX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 112, Issue 3, 1 March 1985, Pages 373–374, https://doi.org/10.1111/j.1365-2133.1985.tb04867.x Published: 01 March 1985
Effects of low doses of inhaled fluticasone propionate on inflammation and remodelling in persistent‐mild asthma
Authors: A. M. Vignola, L. Riccobono, M. Profita, A. Foresi, R. Di Giorgi, D. Guerrera, M. Gjomarkaj, P. Di Blasi, P. L. Paggiaro
Journal: Allergy (2005)

In asthma a dysregulation of eosinophil apoptosis and an imbalance of metalloproteinase‐9 (MMP‐9) and tissue inhibitor metalloproteinase‐1 (TIMP‐1) play an important role in airway inflammation and remodelling. We evaluated the effects of a low dose of inhaled fluticasone proprionate (FP) (100 μ g bid by Diskus) for 4 weeks in 24 steroid naive patients with mild persistent asthma, symptomatic and with a sputum eosinophilia ≥3% on clinical outcomes and inflammatory markers such as the induced sputum eosinophils, the induced sputum apoptotic eosinophils, the levels of MMP‐9 and TIMP‐1 and their molar ratio in the induced sputum supernatants. After FP treatment forced expiratory volume (FEV1) and FEV1/forced vital capacity values, PEF (L/min), sputum apoptotic eosinophils, and MMP‐9/TIMP‐1 molar ratio in sputum supernatants of asthmatic subjects were significantly increased in comparison with baseline, while sputum eosinophils significantly decreased. Change (Δ) in FEV1 after treatment with FP negatively correlated with the Δ in sputum eosinophils, while the Δ in MMP‐9 values positively correlated with Δ in TIMP‐1 values. This study shows that the clinical improvement achieved by the use of low doses of FP in asthmatics is related, at least in part, to the resolution of eosinophilic inflammation and the downregulation of remodelling markers.