Fatty Liver and Pleural Effusion with Ibuprofen Therapy
Authors: JAIME F. BRAVO
Journal: Annals of Internal Medicine (1977)

Brief Reports1 August 1977Fatty Liver and Pleural Effusion with Ibuprofen TherapyJAIME F. BRAVO, M.D., MICHAEL P. JACOBSON, M.D., BENNY F. MERTENS, M.D.JAIME F. BRAVO, M.D.Search for more papers by this author, MICHAEL P. JACOBSON, M.D.Search for more papers by this author, BENNY F. MERTENS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-200 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNew nonsteroidal anti-inflammatory agents have been notably free from serious side effects. We report here a case of fatal fatty metamorphosis of the liver and pleural effusions in an atopic individual with mixed connective tissue disease treated with ibuprofen (Motrin®) and ampicillin.A 48-year-old woman was first seen on 19 June 1975. She complained of symmetrical polyarthritis for 7 years as well as dry eyes and mouth, Raynaud's phenomenon, dysphagia, and weight loss for the last year. Only aspirin, 2.6 g daily, had been taken for the 3 months before her initial evaluation. She was allergic to streptomycin and para-aminosalicylic...References1. THOMPSONFOXNEWELL MHD: Ibuprofen in the treatment of arthritis. Med Proc 14:579-582, 1968 Google Scholar2. BROOKSSCHLAGELSEKHARSOBOTA CCNJ: Tolerance and pharmacology of ibuprofen. Curr Ther Res 15:180-190, 1973 MedlineGoogle Scholar3. REINICKEKLINGER CW: Influence of ibuprofen on drug-metabolizing enzymes in rat liver in vivo and in vitro. Biochem Pharmacol 24:145-147, 1975 CrossrefMedlineGoogle Scholar4. CUTHBERT M: Adverse reactions to non-steroidal antirheumatic drugs. Curr Med Res Opin 2:600-610, 1974 CrossrefMedlineGoogle Scholar5. LAWKNIGHT IH: Jaundice associated with naproxen. N Engl J Med 295:1201, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Colorado Medical Center Denver, CO 80218 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIdentification of an isoform catalyzing the CoA conjugation of nonsteroidal anti-inflammatory drugs and the evaluation of the expression levels of acyl-CoA synthetases in the human liverSystematic review: ibuprofen-induced liver injuryProtective role of c‐Jun N‐terminal kinase‐2 (JNK2) in ibuprofen‐induced acute liver injuryA simple transcriptomic signature able to predict drug-induced hepatic steatosisMechanisms Underlying the Hepatotoxicity of Nonsteroidal Antiinflammatory DrugsNonsteroidal Antiinflammatory Drugs and Leukotriene Receptor AntagonistsCentral role of mitochondria in drug-induced liver injuryHepatic injury due to drugs, herbal compounds, chemicals and toxinsIbuprofen-induced hypersensitivity syndromeMitochondrial Involvement in Drug-Induced Liver InjuryPredicting Drug‐Induced Hepatotoxicity: In Vitro , In Silico and In Vivo ApproachesDrug-Induced Respiratory Disease in Connective Tissue DiseasesIbuprofen-Induced Hepatotoxicity in Patients With Chronic Hepatitis C: A Case SeriesNSAID-INDUCED HEPATOTOXICITYHEPATOTOXICITY OF ANALGESICS AND ANTI-INFLAMMATORY AGENTSInhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicityHepatotoxityPulmonary Disease Due to Antirheumatic AgentsSevere systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapyChanges in body temperature after administration of antipyretics, LSD, Δ9-THC and related agents: IIRare adverse reactions to non-steroidal anti-inflammatory drugsAdverse reactions to nonsteroidal anti-inflammatory drugs diclofenac compared with other nonsteroidal anti-inflammatory drugsNon-steroidal and Analgesic Therapy in the ElderlyPirprofen-induced fulminant hepatitisDrug effects on the liverDrug-Induced Interstitial Lung DiseasesDrugs and Liver Disease: A Tabular Compilation of Drugs and the Histopathological Changes That Can Occur in the LiverClinical associations between arthritis and liver disease.Anti-inflammatory analgesics and drugs used in rheumatism and goutDrug-Induced Microvesicular Steatosis and Steatohepatitis 1 August 1977Volume 87, Issue 2Page: 200-201KeywordsFatty liverIbuprofenLiverMixed connective tissue diseaseMouthNSAIDsPleural effusionRaynaud syndromeStreptomycinWeight loss Issue Published: 1 August 1977 PDF downloadLoading ...