tbuckley/cabot-search huggingface dataset:
Economies in NHS are being made on "arbitrary basis," BMA survey finds
Authors: N. Hawkes
Journal: BMJ (2010)

Despite reassurances from the government, the economic crisis is beginning to have an effect on the NHS, a survey by the British Medical Association indicates.

Local negotiating committees were asked whether they were aware of redundancies, unfilled posts, recruitment freezes, and changes to services or capital plans and how much, if anything, the local trust board was seeking to save.

Around a third of the negotiating committee chairs responded, of whom one in four said that redundancies were planned, for the most part of non-medical staff. Almost two thirds of respondents (62%) said that recruitment had been frozen, mostly of nurses’ posts.

More than half (55%) of those who said there was no explicit freeze said that nevertheless vacancies were unfilled; 72% said that clinical services …
Another devastating complication of the Schnitzler syndrome: AA amyloidosis
Authors: K. Claes, B. Bammens, M. Delforge, P. Evenepoel, D. Kuypers, Y. Vanrenterghem
Journal: British Journal of Dermatology (2007)

Conflicts of interest: none declared. Sir, The Schnitzler syndrome is a rare condition characterized by chronic urticaria in association with monoclonal IgM gammopathy. Other features of the syndrome are fever, elevated erythrocyte sedimentation rate (ESR), arthralgia, bone pain, osteosclerotic bone lesions, leucocytosis, hepatosplenomegaly and lymphadenopathy. Therapy is often unsatisfactory,1, 2 and to date no spontaneous complete remissions have been reported. We describe a patient who developed AA amyloidosis 18 years after presentation. In 1986, a 54‐year‐old man presented to the rheumatology department with a 3‐year history of bone pain accompanied by fever. Laboratory examination revealed an elevated ESR (69 mm in the first hour) and a slightly elevated level of IgM (4 g L−1) (normal 0·57–3·4). Bone marrow examination showed a normal plasmacytosis of 4% (normal 0–5%). Bone scintigraphy showed pathological bone turnover in both knees and left femur with bilateral fibrostosis on spot X‐rays. A tentative diagnosis of osteomyelitis was made. Because ESR and leucocyte count remained elevated, despite antibiotic therapy treatment with nonsteroidal anti‐inflammatory drugs (NSAIDs) was initiated. This gave a marked improvement of his symptoms but his inflammatory parameters remained high. He also developed nonpruritic urticarial lesions that did not respond to the treatment with NSAIDs.
Managing skin toxicities related to panitumumab
Authors: Hagit Bergman, Tara Walton, Ryan Del Bel, Jack T. Seki, Ava Rafii, Wei Xu, Gideon Koren, Neil Shear, Monika K. Krzyzanowska, Doris Howell, Geoffrey Liu
Journal: Journal of the American Academy of Dermatology (2014)
Enterococcal Endocarditis: A Report of Nineteen Cases with Long-Term Follow-up.
Authors: D. Kaye
Journal: Annals of Internal Medicine (1961)

s1 May 1961Enterococcal Endocarditis: A Report of Nineteen Cases with Long-Term Follow-up.D. Kaye, M.D., M. G. Koenig, M.D.D. Kaye, M.D.Search for more papers by this author, M. G. Koenig, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1055_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGood results have been achieved in the therapy of endocarditis caused by penicillin-sensitive streptococci. However, the treatment of endocarditis caused by penicillin-resistant streptococci, usually of the enterococcal group, continues to be associated with a significant number of therapeutic failures. The present paper reviews the clinical data, therapy, and long-term follow-up of 19 patients with enterococcal endocarditis seen at The New York Hospital since 1945. The cure and long-term survival rate in this series compare favorably with those obtained in Streptococcus viridans endocarditis.The female patients were of child-bearing age and the males were from an older age group. The most... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySolitary myeloma: Clinical and prognostic features of a review of 114 casesThe role of radiation therapy in the management of plasma cell tumorsREFERENCES 1 May 1961Volume 54, Issue 5Page: 1055-1056KeywordsAge groupsEndocarditisGroup A streptococciStreptococcus ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Pernicious Anemia in Negroes
Authors: J. G. BOHORFOUSH
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 September 1971Pernicious Anemia in NegroesJ. G. BOHORFOUSH, M.D.J. G. BOHORFOUSH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-3-474 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drs. Hart and McCurdy, in a letter to the Editor, "Pernicious Anemia in Negroes" (1), state that pernicious anemia is frequent in negroes and has the same characteristics as that of white patients. In the age group that they discuss, the latter is correct. He is undoubtedly dealing with a biased sample. In our hospital population, which reflects the general population, pernicious anemia in the negro is relatively uncommon in the age group that they describe, but in the age group under 40, of which they report no cases, it is far more common in the negro...Reference1. HARTMCCURDY RP: Pernicious anemia in Negroes (letter). Ann Intern Med 74:448, 1971 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. G. BOHORFOUSH, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRacial Patterns in Pernicious Anemia 1 September 1971Volume 75, Issue 3Page: 474-474KeywordsAge groupsPernicious anemia ePublished: 1 December 2008 Issue Published: 1 September 1971 PDF downloadLoading ...
Intracholedochal Knotting of a Guide-Wire
Authors: B. Kayhan, M. Akdoğan, O. Sezgin, S. Dişibeyaz, B. Şahin
Journal: Endoscopy (2002)

Figure 1 A 56-year-old man was diagnosed with distal cholangiocellular carcinoma, and treatment with placement of a biliary stent by endoscopic retrograde cholangiopancreatography (ERCP) was planned. After the selective cannulization of the common bile duct, we tried to find a way through to the mass with a black guide-wire, but the tip of the guide-wire became knotted. The knot was recognised at fluoroscopy
Psychological Care of Adults with Rheumatoid Arthritis
Authors: MALCOLM P. ROGERS
Journal: Annals of Internal Medicine (1982)

Physicians treating patients with chronic rheumatoid arthritis spend a considerable amount of time dealing with the psychological and social aspects of the disease. The patients' reaction to the disease can be related to age, experience, personality, and environment at work and at home. Common problems include loss of independence and self esteem, relations with family and friends, employment, and management of pain. Physicians should be attentive to the psychosocial aspects of rheumatoid arthritis and recognize their dynamic interactions to minimize their impact.
Preimplantation Genetic Diagnosis (PGD) for Genetic Prion Disorder Due to F198S Mutation in the<i>PRNP</i>Gene
Authors: Alice Uflacker, P. Murali Doraiswamy, Svetlana Rechitsky, Tricia See, Michael Geschwind, Ilan Tur-Kaspa
Journal: JAMA Neurology (2014)

<h3>Importance</h3> To describe the first case of preimplantation genetic diagnosis (PGD) and in vitro fertilization (IVF) performed for the prevention of genetic prion disease in the children of a 27-year-old asymptomatic woman with a family history of Gerstmann-Sträussler-Sheinker syndrome (GSS). <h3>Observations</h3> PGD and fertilization cycles resulted in detection of 6 F198S mutation-free embryos. Of these, 2 were selected for embryo transfer to the patient's uterus, yielding a clinical twin pregnancy and birth of healthy but slightly premature offspring with normal development at age 27 months. <h3>Conclusion and Relevance</h3> IVF with PGD is a viable option for couples who wish to avoid passing the disease to their offspring. Neurologists should be aware of PGD to be able to better consult at-risk families on their reproductive choices.
Infant Exposures and Development of Type 1 Diabetes Mellitus
Authors: Brittni Frederiksen, Miranda Kroehl, Molly M. Lamb, Jennifer Seifert, Katherine Barriga, George S. Eisenbarth, Marian Rewers, Jill M. Norris
Journal: JAMA Pediatrics (2013)

<h3>Importance</h3> The incidence of type 1 diabetes mellitus (T1DM) is increasing worldwide, with the most rapid increase among children younger than 5 years of age. <h3>Objective</h3> To examine the associations between perinatal and infant exposures, especially early infant diet, and the development of T1DM. <h3>Design</h3> The Diabetes Autoimmunity Study in the Young (DAISY) is a longitudinal, observational study. <h3>Setting</h3> Newborn screening for human leukocyte antigen (HLA) was done at St. Joseph's Hospital in Denver, Colorado. First-degree relatives of individuals with T1DM were recruited from the Denver metropolitan area. <h3>Participants</h3> A total of 1835 children at increased genetic risk for T1DM followed up from birth with complete prospective assessment of infant diet. Fifty-three children developed T1DM. <h3>Exposures</h3> Early (&lt;4 months of age) and late (≥6 months of age) first exposure to solid foods compared with first exposures at 4 to 5 months of age (referent). <h3>Main Outcome and Measure</h3> Risk for T1DM diagnosed by a physician. <h3>Results</h3> Both early and late first exposure to any solid food predicted development of T1DM (hazard ratio [HR], 1.91; 95% CI, 1.04-3.51, and HR, 3.02; 95% CI, 1.26-7.24, respectively), adjusting for the HLA-DR genotype, first-degree relative with T1DM, maternal education, and delivery type. Specifically, early exposure to fruit and late exposure to rice/oat predicted T1DM (HR, 2.23; 95% CI, 1.14-4.39, and HR, 2.88; 95% CI, 1.36-6.11, respectively), while breastfeeding at the time of introduction to wheat/barley conferred protection (HR, 0.47; 95% CI, 0.26-0.86). Complicated vaginal delivery was also a predictor of T1DM (HR, 1.93; 95% CI, 1.03-3.61). <h3>Conclusions and Relevance</h3> These results suggest the safest age to introduce solid foods in children at increased genetic risk for T1DM is between 4 and 5 months of age. Breastfeeding while introducing new foods may reduce T1DM risk.
The Visible Human
Authors: Ian P. Wicks
Journal: Annals of Internal Medicine (2014)

Ad Libitum2 December 2014The Visible HumanIan P. Wicks, MB BS, PhDIan P. Wicks, MB BS, PhDFrom Melbourne, Australia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-1851 Audio Reading - “The Visible Human” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Visible Human," by I.P. Wicks. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The line ... Author, Article, and Disclosure InformationAffiliations: From Melbourne, Australia.Current Author Address: Ian P. Wicks, MB BS, PhD; e-mail, [email protected]edu.au. PreviousarticleNextarticle Advertisement Audio Reading - “The Visible Human” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Visible Human," by I.P. Wicks. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 2 December 2014Volume 161, Issue 11Page: 844KeywordsBody weightHeartSkeleton ePublished: 2 December 2014 Issue Published: 2 December 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Incorrect Primer Sequences in the Article by Duval et al (Arthritis Rheum, October 2009)
Authors: Elise Duval, Sylvain Leclercq, Jean-Marc Elissalde, Magali Demoor, Philippe Galéra, Karim Boumédiene
Journal: Arthritis & Rheumatology (2014)

In the article by Duval et al in the October 2009 issue of Arthritis & Rheumatism (pages 3038–3048), the primer sequences for the aggrecan gene, listed in the “Chromatin Immunoprecipitation (ChIP) Assay” section of Materials and Methods, were shown incorrectly. The sequences actually used in the study (taken from the human sequence of the promoter of AGC1 gene [accession no. AF031586] and corresponding to nucleotides 60–82 [forward] and 220–240 [reverse]) were as follows: forward 5′-AATTTGAAGACCCAGAGACTCGC, reverse 5′-GCTACTGTCGGCCACGATTT.
"VIBURNUM PRUNIFOLIUM."Read in the Section on Materia Medica and Pharmacy, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: H. R. HOLMES
Journal: JAMA (1894)

It has been said that drug medication is a popular delusion of the nineteenth century. In these days of polypharmacy, the value of a single drug can not be always satisfactorily decided. The commerce of drugs, too, suggests so rapid an introduction of new remedies that even the names of many are quickly forgotten. It is rare that a remedy is discovered which will occupy an entirely new place in therapeutics. The reliable effects of remedies now being introduced and those, the actions of which are yet to be studied, will be proven, and yet seldom may it not be said that these can, at best, but substitute those whose offices have been faithfully fulfilled for long periods of time. Since we have so many drugs credited with such similarity of action surely choice will ramble, hence the reason that the true value of some of our most valuable remedies
Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
Authors: Dennis A. Smith, Barry C. Jones, Donald K. Walker
Journal: Medicinal Research Reviews (1996)

Drug metabolism input to the discovery process had historically been on an empirical case-by-case basis, since, detailed descriptors of the effect on pharmacokinetics of a change in structure or physicochemical property were not available. Considerable advances have been made in recent years, such that basic rules can be applied to predict the behavior of a compound in man based on physicochemistry and structure. This is particularly true in the areas of absorption, distribution, and clearance. In particular, knowledge of the reactions catalyzed by the enzymes of drug metabolism, including the cytochrome P450 super family, can be used in the design of new chemical entities, together with the usual pharmacological-derived SAR. The combination of both pharmacokinetics and pharmacodynamics at the discovery stage leads to drugs with optimum performance characteristics. Such drugs are easier to develop, representing a huge saving in resources. Moreover, the marketed compound is much more likely to find high clinical utilization. This review uses dofetilide, fluconazole, and amlodipine to highlight the multifaceted consequences of changing chemical structure, in terms of drug disposition, and reinforces these principles with examples from the literature.
Effects of nonfibrous minerals in the V79-4 cytotoxicity test.
Authors: G H Pigott, P J Pinto
Journal: Environmental Health Perspectives (1983)

The use of the V79-4 system as a primary screen for fiber carcinogenicity is dependent on the observed correlation between cytotoxicity of the test material in the system and mesothelioma following intrapleural injection in animals. This correlation has been established for relatively pure samples of fibrous minerals. The wider application of the system as a screen for industrial dusts may depend on the ability of the system to show an unequivocal response to small yet significant percentages of fibrous dust in the presence of a large excess of nonfibrous material. Some materials tested, including platy minerals, show a response in the test which, while clearly less than that from UICC asbestos samples, could be construed as a positive result. Some, though not all, of these minerals show a nonlinear dose response in the test. This anomalous dose response may aid in the identification of some false positive results but the variety of responses to nonfibrous minerals places a limit on the predictive value of the test mixtures. Results obtained from mixtures of "standard" dust samples suggest this limit is reached at or above 10% fibrous content. Such levels would be significant in terms of human exposure. Extension of the concentration range tested does not improve the predictive value of the test.
Optimization of Intraocular Lens Constant Improves Refractive Outcomes in Combined Endothelial Keratoplasty and Cataract Surgery
Authors: Gustavo Bonfadini, John G. Ladas, Hamilton Moreira, Mauro Campos, Mario Matthaei, Beatriz Muñoz, Kim Pratzer, Albert S. Jun
Journal: Ophthalmology (2012)
An Extracorporeal Device to Treat Barbiturate Poisoning
Authors: Thomas F. Nealon
Journal: JAMA (1966)

Each year in the United States there are more than 2,000 deaths due to barbiturates, accounting for more than 7% of all suicides.<sup>1</sup>Furthermore, in spite of all the new, potentially lethal pharmaceuticals introduced, barbiturates have been responsible for an increasing proportion of attempted suicides. This trend has been most marked in the last five years. When one considers that an estimated 7% of barbiturate suicide attempts are fatal<sup>2</sup>the incidence of barbiturate poisonings is apparently quite high. Several methods have been developed to treat the patient who is prostrated from an overdose of sleeping pills. These range from supportive therapy,<sup>3</sup>water diuresis,<sup>4</sup>alkaline diuresis,<sup>5-7</sup>alkaline or protein peritoneal dialysis,<sup>8</sup>to hemodialysis.<sup>9-11</sup>Although these methods are all applicable, a method of treatment more accessible, more rapid, and more economic would be desirable. In the past, most investigations with resins have been concerned with
Computed Tomographic Colonography (Virtual Colonoscopy): Blinded Prospective Comparison with Conventional Colonoscopy for the Detection of Colorectal Neoplasia
Authors: A. Laghi, R. Iannaccone, I. Carbone, C. Catalano, V. Panebianco, E. Di Giulio, A. Schillaci, R. Passariello
Journal: Endoscopy (2002)

Background and Study Aims: Computed tomographic colonography (CTC), also known as virtual colonoscopy, is a recently introduced imaging modality for the detection of colorectal neoplasia. The aim of our study was to evaluate the performance of CTC in a blinded comparison with conventional colonoscopy. Patients and Methods: A total of 66 consecutive, symptomatic patients underwent spiral computed tomography (CT) examination after standard bowel preparation. CT images were analyzed and subsequently compared with conventional colonoscopy findings.
Contact Dermatitis Due to Formaldehyde in Clothing Textiles
Authors: Silas E. O'Quinn
Journal: JAMA (1965)

Formaldehyde resins are widely used in the textile industry in textile finishing. Many wrinkle-proof, creaseresistant, and waterproof fabrics have been treated in this manner. Contact dermatitis due to formaldehyde contained in textiles has been reported from the European countries but no authenticated cases have been reported in the United States. This report describes three patients with allergic contact dermatitis due to formaldehyde contained in wearing apparel. The patients had positive patch tests to formaldehyde and to samples of textiles shown by chemical analysis to contain formaldehyde. There was correlation between the outbreaks of dermatitis and the use of formaldehyde-containing fabrics.
Cost-Effectiveness of Biologics in Early Rheumatoid Arthritis
Authors: Maarten Boers
Journal: Annals of Internal Medicine (2010)

Letters2 March 2010Cost-Effectiveness of Biologics in Early Rheumatoid ArthritisMaarten Boers, MSc, MD, PhDMaarten Boers, MSc, MD, PhDFrom VU University Medical Center, 1007 MB, Amsterdam, the Netherlands.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-5-201003020-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I think the authors and I agree on most of the issues, but we differ in the wording of our conclusions. It is wise to avoid firm conclusions in the face of shaky evidence. A model can never fully replace reality, and we probably need another 10 years of additional experience with biologics to be fully certain of their cost-effectiveness. Nevertheless, when we trust the model, and it points unmistakably in 1 direction, we shouldn't be afraid to clearly communicate what it shows. This is especially important in the area of biologics in rheumatoid arthritis, where intense marketing ...References1. Da Silva JA, Jacobs JW, Kirwan JR, Boers M, Saag KG, Inês LB, et al. Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data. Ann Rheum Dis. 2006;65:285-93. [PMID: 16107513] CrossrefMedlineGoogle Scholar2. Caplan L, Wolfe F, Russell AS, Michaud K. Corticosteroid use in rheumatoid arthritis: prevalence, predictors, correlates, and outcomes. J Rheumatol. 2007;34:696-705. [PMID: 17299838] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Maarten Boers, MSc, MD, PhDAffiliations: From VU University Medical Center, 1007 MB, Amsterdam, the Netherlands.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness of Biologics as First-Line Treatment of Rheumatoid Arthritis: Case Closed? Maarten Boers Treatment of Very Early Rheumatoid Arthritis With Symptomatic Therapy, Disease-Modifying Antirheumatic Drugs, or Biologic Agents Axel Finckh , Nick Bansback , Carlo A. Marra , Aslam H. Anis , Kaleb Michaud , Stanley Lubin , Marc White , Sonia Sizto , and Matthew H. Liang Cost-Effectiveness of Biologics in Early Rheumatoid Arthritis Axel Finckh , Nick Bansback , and Matthew H. Liang Metrics 2 March 2010Volume 152, Issue 5Page: 334KeywordsBiologicsConflicts of interestDisease modifying antirheumatic drugsDrugsGlucocorticoid therapyRheumatoid arthritisSafety ePublished: 2 March 2010 Issue Published: 2 March 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...