tbuckley/cabot-search huggingface dataset:
Long-term therapy and retreatment of hepatorenal syndrome type 1 with ornipressin and dopamine
Authors: Veit Gülberg, Manfred Bilzer, Alexander L. Gerbes
Journal: Hepatology (1999)

Peripheral vasodilation is considered an important factor in the pathophysiology of the hepatorenal syndrome (HRS). Therefore, the aim of this study was to evaluate the therapeutic potential of the vasoconstrictor ornipressin plus dopamine in the treatment of the most severe form of HRS, namely HRS type 1. Seven cirrhotic patients (creatinine clearance 15 +/- 1 mL/min, UNaV 7 +/- 2 mmol/24 h) with HRS type 1 were included in the study after normalization of central venous pressure with intravenous albumin and low-dose dopamine had failed to prevent further deterioration of renal function. Ornipressin was given continuously (intravenous 6 IU/h) in combination with dopamine (2-3 microgram/kg/min) until creatinine clearance had increased to above 40 mL/min or adverse events prevented further treatment. HRS was reverted in 4 of 7 patients after 5 to 27 days (creatinine clearance 51 +/- 4 mL/min, UNaV 47 +/- 11 mmol/24 h) of treatment. Withdrawal was necessary in 1 patient after 15 days because of intestinal ischemia. Treatment failure was observed in 2 of 7 patients (creatinine clearance 19 +/- 10 mL/min, UNaV 8 +/- 3 mmol/24 h). Two of 4 responders had recidivant HRS 2 and 8 months after initial therapy, respectively. HRS in 1 of these patients was reverted with 18 days of ornipressin retreatment. The other patient had to be withdrawn from ornipressin after 2 hours because of ventricular tachyarrhythmia. Altogether, 3 of 7 patients survived HRS type 1, 1 after successful ornipressin therapy and liver transplantation, 1 with 2 successful courses of ornipressin, and 1 with liver transplantation after ornipressin treatment had failed. Thus, ornipressin plus dopamine can be a useful therapeutic option in patients with HRS type 1, especially as bridge to liver transplantation.
Histological renal osteodystrophy, and 25 hydroxycholecalciferol and aluminum levels in patients on continuous ambulatory peritoneal dialysis
Authors: Raman Gokal, Jose M. Ramos, Hewett A. Ellis, Ian Parkinson, Vicky Sweetman, Jim Dewar, Michael K. Ward, David N.S. Kerr
Journal: Kidney International (1983)
The Adolescence of Child Health Services Research
Authors: Lisa A. Simpson
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Hepatitis B virus infection in thalassaemia major treated in London and Athens.
Authors: G Mieli-Vergani, D Vergani, Y White, A P Mowat, B Wonke, C J Kennedy, A Karameau, D Politis, M Laulicht, A V Hoffbrand
Journal: BMJ (1984)

Hepatitis B virus infection in thalassaemia major treated in London and Athens Chronic liver disease is a common complication of , thalassaemia major.'This complication might result from iron overload or blood- borne viral infection, or both.We investigated the incidence of hepatitis B virus infection in two groups of patients with thalas- saemia major on identical iron chelation treatment-one in an area endemic for hepatitis and one in a non-endemic area.
Preservation of calcium pyrophosphate dihydrate crystals: effect of Mayer's haematoxylin staining period
Authors: T Ohira
Journal: Annals of the Rheumatic Diseases (2001)

To clarify the deleterious effects of Mayer's haematoxylin staining procedure which result in a decrease in, or complete loss of, the number of calcium pyrophosphate dihydrate (CPPD) crystals, and to determine the proper staining period for preserving the crystals in a histological paraffin section of articular tissues.Paraffin sections of CPPD crystal-bearing articular tissues of six patients were stained with Mayer's haematoxylin for 3, 8, or 15 minutes, and subsequently with eosin for one minute. The specimens were examined with an Olympus BHS polarised light microscope. The pH of Mayer's haematoxylin solution was measured with a TOA pH meter.Positive birefringent CPPD crystals were seen clearly in all specimens stained with Mayer's haematoxylin for three minutes. The specimens stained for eight minutes showed a reduced number of crystals. No crystals were seen in the specimens stained for 15 minutes. Ordinary light microscopy showed no notable differences in the stainability of nucleus, cell membrane, and their surrounding tissues among specimens when stained with Mayer's haematoxylin for either 3, 8, or 15 minutes. The pH of Mayer's haematoxylin solution was 2.31.To find CPPD crystals in the paraffin sections of articular tissues, the staining period with Mayer's haematoxylin should be limited to three minutes. The longer the staining period, the greater the reduction in the number of crystals owing to the strong acidity of the haematoxylin solution. A staining period of 15 minutes causes a complete loss of CPPD crystals.
Why does NICE not recommend laparoscopic herniorraphy?
Authors: R. W Motson
Journal: BMJ (2002)

NICE's reluctance to recommend laparoscopic repair of hernias is based mainly on economic considerations, some of which are inaccurate, according to Roger Motson

More than 100 000 inguinal herniorraphies are carried out each year in the United Kingdom, making it one of the commonest operations. Newer techniques have superseded the simple suture technique popularised by Bassini more than 100 years ago: firstly the tension-free darn with monofilament nylon and then the Lichtenstein repair with a polypropylene mesh patch. 1 2 Although there was no initial randomised trial of the Lichtenstein technique, it rapidly gained popularity during the past decade. Laparoscopic repair, which places a considerably larger polypropylene mesh patch against the inner surface of the abdominal wall than that used in the Lichtenstein technique, was first performed about 10 years ago. 3 4 This larger patch reinforces the entire groin, covering the sites of both indirect and direct inguinal hernias and also of femoral hernias. The position of the mesh is the same as that used in the open Stoppa repair,5 but the laparoscopic approach has the great advantage of avoiding the large incision required for this technique.

#### Summary points

Inguinal herniorraphy is one of the commonest operations in the United Kingdom

Laparoscopic herniorraphy is less painful postoperatively than traditional open repair and allows the patient to return to work more quickly

The true costs of laparoscopic repair are lower than those of open repair, particularly when it allows detection and simultaneous repair of an undiagnosed contralateral hernia

Surgeons are under-represented on NICE's appraisal panel

Laparoscopic repair has been subject to a number of randomised trials, recently summarised by the European Hernia Trials Group, who found that the incidences of recurrence in laparoscopic and Lichtenstein repairs were similar (2.3% and 2.9%, respectively).6 The only differences in clinical outcomes were a …
Occupational and Environmental Disease
Authors: ROSEMARY K. SOKAS
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 February 1984Occupational and Environmental DiseaseROSEMARY K. SOKAS, M.D., M.O.H.ROSEMARY K. SOKAS, M.D., M.O.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-2-321_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The American Lung Association's report (1) on taking the occupational history is a useful reminder of the importance of occupational and environmental illness to the practicing internist. A few additional points may be worth the attention of internists as they incorporate the occupational history into practice, particularly in group practice or in house officer training settings.Exposures identified in the history belong in the active problem list in the same way that drug allergies do. Problem lists will remind physicians of the need for intervention or screening, such as providing additional emphasis on smoking cessation or annual...References1. . Taking the occupational history. Ann Intern Med. 1983;99:641-51. LinkGoogle Scholar2. Medical Surveillance Requirements and NIOSH Recommendations for Employees Exposed to Toxic Substances and Other Work Hazards. Washington, D.C.: NASA Occupational Health Office; 1980. Available from the National Institute for Occupational Safety and Health, 4676 Columbia Parkway; Cincinnati, OH 45226 Google Scholar3. RUTSTEIN D, MULLAN R, FRAZIER T, HALPERIN W, MELIUS J, and SESTITO J. Sentinel health events (occupational): a basis for physician recognition and public health surveillance. Am J Public Health. 1983;73:1054-62. CrossrefMedlineGoogle Scholar4. Occupational Health and Safety: COSH Groups (Fact Sheet) 1983, No. 3. Available from the United Auto Workers Health and Safety Department, 8000 East Jefferson; Detroit, MI 84214. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROSEMARY K. SOKAS, M.D., M.O.H. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOccupational sentinel health events: An up-dated list for physician recognition and public health surveillance 1 February 1984Volume 100, Issue 2 Page: 321-322 Keywords Allergy and immunology Drugs Lungs Smoking cessation ePublished: 1 December 2008 Issue Published: 1 February 1984 PDF downloadLoading ...
New Ways to Get Pregnant
Authors: Marcia Angell
Journal: New England Journal of Medicine (1990)

Last month, newspapers reported two legal disputes involving new reproductive methods. The first (Davis v. Davis)1 was a battle for custody of seven frozen embryos, conceived by in vitro fertilization two years ago. A lower court had referred to them as "children in vitro," and granted them full protection under the law. The Tennessee Court of Appeals gave joint custody to the parents, who divorced shortly after the embryos were created. Since they cannot agree on the disposition of the embryos, it would seem that the "children in vitro" are destined to enjoy their legal protection in the . . .
Mechanisms responsible for the initiation and maintenance of atrial fibrillation assessed by noncontact endocardial mapping system
Authors: Seung Woon Rha, Young-Hoon Kim, Sang Weon Park, Cheol Ung Choi, Seong Mi Park, Wan Joo Shim, Young Moo Ro
Journal: Journal of the American College of Cardiology (2003)
Photodynamic Therapy for Villous Adenomas of the Colon and Rectum
Authors: C. S. Loh, P. Bliss, S. G. Bown, N. Krasner
Journal: Endoscopy (1994)

Endoscopic thermal laser therapy of colorectal villous adenomas is associated with a high recurrence rate due to incomplete tumor ablation, as treatment over carries a risk of perforation. Photodynamic therapy has been shown to be a promising in the treatment of small malignant tumors, and may be useful for benign adenomas. Eight patients with nine colosigmoid villous adenomas measuring 1-5 cm in length were treated with photodynamic therapy using either haematoporphyrin derivative or Photofrin as photosensitizer and multiple (4-16) applications of interstitial photoirradiation with red light (630 nm, 100 mW × 500 s per application). All but one adenoma had previously been incompletely treated with Nd-YAG laser therapy. Some skin sensitivity to light was seen in one patient. Seven adenomas were eradicated (follow-up 9-56 months, median = 12) as judged by follow-up endoscopy and biopsy. No local complications were seen. Substantial necrosis was produced in the other two adenomas, but they were not completely destroyed, probably due to inadequate light. PDT holds promise in the non-surgical management of villous adenomas, particularly after initial tumour debulking with the Nd-YAG laser.
Growth hormone (GH) response to GH-releasing peptide-6 and GH-releasing hormone in normal-weight and overweight patients with non-insulin-dependent diabetes mellitus
Authors: D. Micić, Dj. Macut, V. Popović, A. Kendereški, M. Šumarac-Dumanović, S. Zorić, C. Dieguez, F.F. Casanueva
Journal: Metabolism (1999)
Affected sib-pair analysis in endometriosis
Authors: Stephen Kennedy, Simon Bennett, Daniel E. Weeks
Journal: Human Reproduction Update (2001)

This paper (i) reviews the current clinical and molecular genetic data which strongly suggest that endometriosis has a genetic basis; (ii) outlines the general principles of affected-sib pair analysis; and (iii) describes the Oxford Endometriosis Gene (OXEGENE) Study which aims, using a positional cloning approach, to identify susceptibility genes involved in the development of the disease.
Fundamentals of Abdominal and Pelvic Ultrasonography
Authors: Wayne S. Chilcote
Journal: JAMA (1976)

The discipline of diagnostic ultrasound presents a definite challenge to authors and publishers due to continued growth and refinement in technology, diagnostic detail, and diagnostic criteria. This challenge has been met by a few books published recently. Although the present volume is clearly devoted to those beginning in ultrasonography, the authors presume that the reader has a basic acquaintance with ultrasound physics and delve immediately into techniques of ultrasound scanning. The chapters are organized on an organ by organ basis and deal mainly with normal anatomy, with only the more common pathologic conditions presented. Extremely rare or unusual cases are not used. Although there is a chapter devoted to gray-scale imaging, the bulk of the book is limited by publishing constraints to bistable images of vintage and recent origin. An extremely valuable section is a series of 12 color illustrations photographed from transverse and sagittal cadaver sections. Each of these
Giardia in the Well
Authors: Stuart A. Smith
Journal: JAMA (1988)

<h3>To the Editor.</h3> —As a curious groundwater microbiologist, I scan<i>JAMA</i>periodically for reports involving possible cases of well contamination by human pathogens. The most recent was the report by Drs Shaw and Stevens<sup>1</sup>that related the case of a physician living on a farm in rural Maryland who contracted giardiasis. While the focus of the report was the patient's arthritis, the authors make several statements about the patient's environment and the mode of transmission for<i>Giardia lamblia</i>, including (1) that the patient raised dogs and horses and had been pulling ticks, (2) that<i>G lamblia</i>was identified in her stool samples and in her well water, and (3) that well water is a prominent source of<i>G lamblia</i>. What really was the source of the patient's<i>G lamblia</i>infection? These protozoa, although cyst forming, are not part of the known normal groundwater flora. Dogs are probably the most
Renal disease and use of topical non-steroidal: anti-inflammatory drugs
Authors: C A O'Callaghan, P A Andrews, C G Ogg
Journal: BMJ (1994)

by misclassification of spontaneously resolving cases.Reported rises in perforation rates with duration of symptoms may also be explained by selection bias due to spontaneous resolution of milder inflammation.'5The perforation rate is therefore worthless as a measure ofquality in the management ofappendicitis.That appendicitis commonly resolves implies that future diagnostic and therapeutic policies should aim at early detection and operation in patients with perforating appendicitis or progressive inflammation and at active observation and investigation ofalternative diagnoses in other patients.Studies on clinical signs and laboratory findings in relation to the degree of inflammation or perforation have shown promising results.289The role of explorative laparoscopy in this context is as yet unclear but may increase the yield of alternative diagnoses in prolonged abdominal pain.30
China’s Health System Reform and Medical Education
Authors: Maxime Maignan
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deep Tissue Traumatism from Roentgen Ray Exposure
Authors: D. Walsh
Journal: BMJ (1897)

MEDICAL JOURNALJ FRO may be set up occasionally on the infliction of.the wound, but this is merely a temporary inconvenience, which can be removed if necessary by pushing the chloroform until the struggling ceases, or until anaesthesia is complete.The following case, taken from the anmsthesia notebook, illustrate the method of administration:AFZULGUNJ HOSPITAL.April 28th, I897.Mir Soobhan Ali, aged 3I, years, male, had food last at 7 o'clock to-day.Is very weak and emaciated, passing twelve to fourteen dysenteric stools a day.Operation, aspiration of liver abscess.Chloro- formist.Miss Tenducey, fourth year student.Administration commenced in one drachm doses at: H. M. S. 8 50 30 Breathing naturally, quiet. 853 30 Chloroform added to the cap, one breath of air. 852 15 Unconscious.Aspirated in seventh space.Six ounces of serum evacuated.8 53 3I Needle withdrawn.8 55 o Patient removed on a stretcher.The entire operation, from the time the chloroform was begun till the patient was taken away, occupied 4t minutes, and there was no sickness or discomfort afterwards.A brief account of the case will show how important a part the partial anaesthesia played in the patient's recovery.He was admitted into the Afzulgunj Hospital on April 21st, I897, suffering from dysentery and a large abscess of the liver.The dysentery was treated throughout with bismuth and Dover's powder, which he is still taking; and the aspirations were carried out as follows:April 22nd.First aspiration under partial anaesthesia with chloroform.Thirty-five ounces of thick sterile pus were evacuated.The operation lasted 9 minutes and 45 seconds.April 24th.Second aspiration under partial anmesthesia with chloro- form.Fourteen ounces of pus were removed; and the operation lasted 5 minutes and 55 seconds.April 25th.Third aspiration,under partial anuesthesia.Eight ounces of pus and serum were evacuated, and the operation lasted 5 minutes and 25 seconds.April 28th.Fourth aspiration under partial anaesthesia.Six ounces of sterile serum only were removed, and the operation lasted 41 minutes.May 6th.Fifth aspiration under partial anaesthesia.The abscess cavity was found entirely empty.The exploratory operation lasted 5 minutes.Rapid improvement had taken place after the aspira- tion on April 28th, when nothing but serum was found, and the temperature remained normal.The patient passes from one to three stools, free from blood and mucus, in the twenty-four hours; he is free from pain and feels quite well.
The role of double-balloon enteroscopy in diagnosis and management of incomplete small-bowel obstruction
Authors: B. Sun, R. Shen, S. Cheng, C. Zhang, J. Zhong
Journal: Endoscopy (2007)

Double-balloon enteroscopy (DBE) is a newly developed endoscopic technique for investigating various small-bowel diseases. The aim of this study was to evaluate the diagnostic yield and therapeutic impact of DBE in patients with incomplete small-bowel obstruction (SBO).This study is a prospective analysis of 45 consecutive patients specifically referred to our hospital between December 2004 and January 2006 for investigation of incomplete SBO that had been confirmed by both clinical symptoms and imaging tests. Patients with a high suspicion of postoperative adhesion were excluded and DBE was performed in stable patients. The final management was guided by the results of DBE and radiographic studies. Demographic, clinical, procedural, and outcome data were collected for analysis.A total of 30 DBEs were performed in 29 patients (11 women, 18 men; mean age 52.0 +/- 13.5 years). DBE identified causes of incomplete SBO in 27 patients (93.1%) and allowed histopathologic evaluation in 17 patients (58.6%). The more common abnormalities detected were small-bowel tumors (48.3%) and strictures caused by Crohn's disease (24.1%). In detecting small-bowel abnormalities, DBE showed a sensitivity of 96.4%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 50%. DBE influenced the therapeutic strategy in 41.4% of patients by adding more information regarding appropriate treatment. Follow-up data were obtained for 26 patients (89.7%), for a mean 9.4 months (range 4-18 months). Of the 26 patients with follow-up, 21 (72.4%) had no further SBO.Double-balloon enteroscopy is a feasible diagnostic tool for detecting the causes of incomplete SBO in patients without a history of abdominal surgery and also influences therapy in patients without a definite cause detected by conventional radiography.
Acute Monarticular Arthritis Following Patellar Metastasis
Authors: Eric P. Gall
Journal: JAMA (1974)

METASTATIC neoplasm to the patella is unusual, and a monarticular arthritis related to such a lesion appearing as the initial sign of a previously unrecognized carcinoma must be rare indeed. In most cases of arthritis associated with malignant neoplasms, the underlying tumor is evident. We describe a patient with monarticular arthritis secondary to metastatic patellar spread of bronchogenic carcinoma as the earliest symptom of his primary tumor. <h3>Report of a Case</h3> A 63-year-old man was admitted to the hospital for evaluation of arthritis in the left knee. The patient had been initially hospitalized at a sanatorium in 1968 for suspected pulmonary tuberculosis; sputum cultures were negative. In spite of this, he received triple antituberculous drug therapy for one year. Three months before his final admission, he noted pain in the left knee, following a fall. The knee became increasingly swollen until he was unable to bear weight. Chest x-ray films