tbuckley/cabot-search huggingface dataset:
America's Neglect of the Nobel Prizes.
Authors: A. E. Engzelius
Journal: JAMA (1906)

Wakefield, Neb., Oct. 29, 1906. <h3>To the Editor:</h3> —Referring to your editorial of April 15, 1905, on "Our attitude toward the Nobel prizes," I would like to ask if any effort has as yet been made to secure any of these prizes for American work? Believing that the expression of jealousy in the news columns ofThe Journal, Dec. 25, 1905, page 1966, shows plainly the existence of misconception or lack of knowledge regarding the method of awarding these prizes, I reproduce the following authoritative description of the "Nobel Foundation" under which name this prize-awarding institution is officially known.<sup>1</sup> "Alfred Nobel bequeathed nearly the whole of his fortune (more than 30 million kronor) to a fund, the interest of which shall be annually paid out to those who during the immediate past 'have conferred the greatest benefit on mankind' in certain lines. The interest is to be divided into
Canadian doctors brace themselves as cannabis becomes legal
Authors: D. Spurgeon
Journal: BMJ (2001)

Canada's new regulations on the medical use of cannabis have drawn criticism from both its medical profession and current users.

The new regulations, which allow cannabis to be used by people with a terminal condition and serious medical illness, came into effect at the end of July and make Canada the first country to take such a step (14 July, p 68).

Peter Barrett, president of the Canadian Medical Association, said that most physicians were reluctant to participate in the government's programme for the medical use of marijuana because they worry about recommending a drug that has …
ASPIRIN FAILURE IS ASSOCIATED WITH WORSE CLINICAL OUTCOME BUT NOT WITH AN INADEQUATE PLATELET RESPONSE TO ASPIRIN IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Roy S. Beigel, Hanoch Hod, Boris Shenkman, Paul Fefer, Naphtali Savion, David Varon, Shlomi Matetzky
Journal: Journal of the American College of Cardiology (2010)
Diastolic characteristics and cardiac energetics of isolated hearts exposed to volume and pressure overload
Authors: P. FRIBERG
Journal: Cardiovascular Research (1988)

The relation between diastolic dimensions and systolic function was studied in isolated rat hearts exposed to pressure (primary hypertension) and to volume load (hyperthyroidism). The hearts were arrested in diastole and cardiac dimensions analysed. Cardiac function was determined using an anterograde working heart preparation. Both models of cardiac overload produced significant left ventricular hypertrophy, however with different design. One concentric and one eccentric form of left ventricular hypertrophy were found in the spontaneously hypertensive rat obtained from two different breeders. An even more pronounced form of eccentric left ventricular hypertrophy was seen in hyperthyroid rats. The hearts with an eccentric form of hypertrophy had a higher maximal stroke volume when perfused at a high aortic pressure than those with a concentric form. At a low aortic pressure and hence a limited coronary perfusion cardiac performance was diminished in both types of spontaneously hypertensive rats but remained normal in hyperthyroid rats. Furthermore, oxygen consumption was reduced in all hypertrophied hearts compared with non-hypertrophied hearts. These data therefore suggest (a) that hearts having an eccentric type of hypertrophy may be in a more favourable situation, delivering a higher stroke volume for a given degree of myocardial fibre shortening; and (b) that the development of coronary vascular structural changes in spontaneously hypertensive rats, thereby increasing vascular resistance, leads to a decrease in left ventricular function at a low coronary perfusion pressure, whereas no such reduction was observed in hyperthyroid hearts, probably owing to a normal vascular resistance.
THE PSYCHOANALYTICAL APPROACH TO THE MASCULINE AND FEMININE PRINCIPLES IN MUSIC
Authors: MARGARET TILLY
Journal: American Journal of Psychiatry (1947)

Mother-complex, shown by lifelong dependency on women or effeminate men, culminating in an attachment to a masculine woman. Feminine tendencies also shown in the enjoyment of soft luxurious life, love of clothes, moodiness, sentimentality, over-subjective attitude, lack of robustness in both physique and creative work. Mother-complex, shown in dependency first on his mother, then transferred first to many women throughout his life and finally to the Church, where the father confessor takes up the mother role. Narcissism shows by his concentration on the effect of his own personality on those around him and his love of all that was showy and ornamental for its own sake. Independence, stability, power and vigour, self-assurance and a voluntary assuming of responsibility and protection towards those about him, a long and happy marriage, pelus a lifetime spent in the glorification of form, add up to an outstandingly mature and masculine personality. A deeply introverted personality, unable to adjust to the outside world, showing evidence of a persecution complex, probably brought about by his deafness. His life, while undoubtedly neurotic, shows no sign of an over-stressed Anima, nor is there evidence of neurotic femininity in his music. Feminine passages in his scores, are the warm, balanced demonstrations found in a man in whom the masculine principle predominates.
Variations in Recommendations of Ethics Consultants-Reply
Authors: Ellen Fox
Journal: JAMA (1994)

In Reply.  —Had our survey respondents felt they needed additional information to select an appropriate recommendation, as Drs Moseley and McCrary suggest, we assume they would have indicated this on their questionnaires by selecting option E (other) and/or by commenting under explain or qualify your recommendation. Instead, most respondents gave specific recommendations in response to every vignette, and few criticized the questionnaire format in general or its lack of detail in particular.  Although it is impossible to accurately and concisely summarize the hundreds of comments we received, we are happy to provide a few of many possible examples in support of our conclusion of wide variability in ethics consultants' recommendations.  Regarding vignette 2 (patient did not want to be kept alive, family members want everything possible done to prolong life), 57% of the respondents selected option A (discontinue fluid and nutrition). Of these, most justified their recommendation by citing the
Obsolescence in the Hospital
Authors: Charles D. Aring
Journal: JAMA (1974)

LARGE hospitals have become disquieting places, as anyone who has recently been a patient there can testify. To begin, the appointments are more expensive than can be afforded, and in general, they hardly can be considered to be arranged for the benefit of the patient. In the hospital family, the patient is usually low man on the totem pole in an organization that is largely for the convenience of others. To put aside for the moment the mundane reasons for the discomfort known to everybody, the business philosophy of obsolescence is abroad in the land, with prosperity contingent on waste. This pervasive need "to be rid of" has extended to human beings. Patients are obsolete, mesmerized—as we have become—by the business ethic because they can no longer contribute to the gross national product. The deterioration of the spirit of the extended family contributes to the widening of the gap between
Effect of L-thyroxine on gastric secretion in the pylorus-ligated rat.
Authors: D W Blair, M J Williams, A J Carr, S J Kilpatrick
Journal: Gut (1965)

EDITORIAL SYNOPSIS L-thyroxine is shown to have an inhibitory effect on gastric secretion initially, but gastric secretion returns to normal some weeks later in spite of continued administration of L-thyroxine.
New rules on storing and using human organs put out for consultation
Authors: Clare Dyer
Journal: BMJ (2005)

New draft guidelines for the storage, use and disposal of human organs and tissue, including donations for transplantation, were issued this week by the new Human Tissue Authority.

The authority, set up under the Human Tissue Act 2004, launched its first round of public consultation with five draft codes covering the key areas of consent, donation for transplantation, post mortem, anatomical examination and removal and storage and disposal. Consultation ends on 4 October.

The authority was set up in response to the revelation in the 1990s that doctors at Bristol Royal Infirmary, …
892 ERK5 IS OVEREXPRESSED IN EXPERIMENTAL LIVER INJURY AND IN HEPATOCELLULAR CARCINOMA (HCC) AND IS MODULATED BY SOLUBLE FACTORS IN HCC CELLS
Authors: E. Rovida, N. Navari, S. Cannito, P. Dello Sbarba, M. Parola, F. Marra
Journal: Journal of Hepatology (2010)
The <i>Pax-5</i> Gene: A Pluripotent Regulator of B-cell Differentiation and Cancer Disease
Authors: Pierre O'Brien, Pier Morin, Rodney J. Ouellette, Gilles A. Robichaud
Journal: Cancer Research (2011)

Abstract The Pax-5 oncogene encodes a potent transcription factor that plays a key role in B-cell development and cancerous processes. In normal B-lymphopoiesis, Pax-5 accomplishes a dual function by activating B-cell commitment genes while concomitantly repressing non–B-lineage genes. Given the pivotal importance of Pax-5–mediated processes in B-cell development, an aberrant regulation of Pax5 expression has consistently been associated with B-cell cancers, namely, lymphoma and lymphocytic leukemias. More recently, Pax-5 gene expression has been proposed to influence carcinogenic events in tissues of nonlymphoid origin by promoting cell growth and survival. However, in other cases, Pax-5 products have opposing effects on proliferative activity, thus redefining its generally accepted role as an oncogene in cancer. In this review, we attempt to summarize recent findings about the function and regulation of Pax-5 gene products in B-cell development and related cancers. In addition, we present new findings that highlight the pleiotropic effects of Pax-5 activity in a number of other cancer types. Cancer Res; 71(24); 7345–50. ©2011 AACR.
Intermittent corticotrophin treatment: Ventilatory tests in asthmatic subjects
Authors: R. C. Lowry, J. S. Mackay, B. Sheridan, J. A. Weaver
Journal: BMJ (1969)

Ventilatory tests (F.E.V.(1)/F.V.C.) have been studied in 16 asthmatic subjects during intermittent administration of corticotrophin, and the responses correlated with the plasma cortisol levels. The improvement in respiratory function was found to last for a longer period than the enhanced adrenocortical activity.
Involvement of the biliary system in autoimmune pancreatitis: a follow-up study
Authors: Kenji Hirano, Yasushi Shiratori, Yutaka Komatsu, Natsuyo Yamamoto, Naoki Sasahira, Nobuo Toda, Hiroyuki Isayama, Minoru Tada, Takeshi Tsujino, Ryo Nakata, Tateo Kawase, Tetsuo Katamoto, Takao Kawabe, Masao Omata
Journal: Clinical Gastroenterology and Hepatology (2003)
Rediscovering Turing's brain
Authors: Alex Kirlik
Journal: Behavioral and Brain Sciences (1997)

The embodied AI paradigm represents a distinct shift toward an ecological perspective on intelligent behavior. I outline how Ballard et al. have made a promising advance in expanding the seat of intelligence to include sensory and motor systems, but they have not gone far enough. Sustained growth toward truly generalizable accounts of intelligent systems will also require expanding the locus of intelligence to include the environmental structure participating in intelligent behavior.
Is day care equivalent to inpatient care for active rheumatoid arthritis? Randomised controlled clinical and economic evaluation
Authors: C M. Lambert, N. P Hurst, J. F Forbes, A. Lochhead, M. Macleod, G. Nuki
Journal: BMJ (1998)

To test the clinical equivalence and resource consequences of day care with inpatient care for active rheumatoid arthritis.Randomised controlled clinical trial with integrated cost minimisation economic evaluation.Rheumatic diseases unit at a teaching hospital between 1994 and 1996.118 consecutive patients with active rheumatoid arthritis randomised to receive either day care or inpatient care.Clinical assessments recorded on admission, discharge, and follow up at 12 months comprised: the health assessment questionnaire, Ritchie articular index, erythrocyte sedimentation rate, hospital anxiety and depression scale, and Steinbrocker functional class. Resource estimates were of the direct and indirect costs relating to treatment for rheumatoid arthritis. Secondary outcome measures (health utility) were ascertained by time trade off and with the quality of well being scale.Both groups had improvement in scores on the health assessment questionnaire and Ritchie index and erythrocyte sedimentation rate after hospital treatment (P < 0.0001) but clinical outcome did not differ significantly between the groups either at discharge or follow up. The mean hospital cost per patient for day care, 798 Pounds (95% confidence interval 705 Pounds to 888 Pounds), was lower than for inpatient care, 1253 Pounds (1155 Pounds to 1370 Pounds), but this difference was offset by higher community, travel, and readmission costs. The difference in total cost per patient between day care and inpatient care was small (1789 Pounds (1539 Pounds to 2027 Pounds) v 2021 Pounds (1834 Pounds to 2230 Pounds)). Quantile regression analysis showed a cost difference in favour of day care up to the 50th centile (374 Pounds; 639 Pounds to 109 Pounds).Day care and inpatient care for patients with uncomplicated active rheumatoid arthritis have equivalent clinical outcome with a small difference in overall resource cost in favour of day care. The choice of management strategy may depend increasingly on convenience, satisfaction, or more comprehensive health measures reflecting the preferences of patients, providers, and service commissioners.
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Authors: Idoya Lahortiga, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Frank Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules P P Meijerink, Jan Cools
Journal: Nature Genetics (2007)
Group-Y Meningococcal Disease
Authors: MARK E. REINECKE
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 May 1975Group-Y Meningococcal DiseaseMARK E. REINECKE, M.D.MARK E. REINECKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-5-719 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article "Group-Y meningococcal disease" by J. D. Smilack in the December issue (Ann Intern Med 81:740-745, 1974) was read with interest. Two cases of pneumonia occurred among 12 cases of group-Y meningococcemia.I wish to present briefly our experience with pneumonitis among cases of group-C meningococcemia seen at Madigan General Hospital during 1969. These data were presented at the VA Armed Forces Pulmonary Disease Research Conference in Cincinnati in 1970 and have not been published.Ninety-four cases of meningococcal disease among recruits were documented by either blood culture or cerebrospinal fluid culture. Admission chest roentgenograms from...References1. YOUNGLAFORCEHEAD LFJ: A simultaneous outbreak of meningococcal and influenza infections. N Engl J Med 287:5-9, 1972 CrossrefMedlineGoogle Scholar2. RISKOHODGES JG: Neisseria meningitidis serogroup Y: incidence and description of clinical illness. Am J Med Sci 267: 345-352, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Marshfield Clinic Marshfield, Wisconsin 54449 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1975Volume 82, Issue 5Page: 719-720KeywordsArmed forcesBloodCerebrospinal fluidMeningococcal diseaseMeningococcemiaPneumoniaPneumonitisPulmonary diseasesThorax Issue Published: 1 May 1975 PDF DownloadLoading ...
Anti-IgM-mediated B cell signaling. Molecular analysis of ligand binding requisites for human B cell clonal expansion and tolerance.
Authors: S M Rudich, K H Roux, R J Winchester, P K Mongini
Journal: The Journal of Experimental Medicine (1988)

The ligand binding requisites for membrane IgM-mediated signaling of human B lymphocyte clonal expansion and B cell tolerance were investigated with a well-characterized set of soluble murine anti-human IgM mAbs. Evaluation of the impact of mu chain domain specificity, affinity, and binding stoichiometry for membrane IgM on antibody-induced regulation of normal and leukemic B cell DNA synthesis revealed that the ligand binding requisites for inducing or, alternatively, suppressing B cell DNA synthesis are significantly different. First, while the induction of S phase entry required micrograms/ml concentrations of ligand, orders of magnitude lower concentrations of ligand sufficed for inhibitory signaling. Second, while an upper affinity threshold for achieving maximal stimulation of B cell DNA synthesis was never detected, inhibitory signaling by bivalent ligands appeared to become relatively affinity independent at Fab binding affinities greater than 7.0 x 10(6) M-1. Third, while a C mu 1-specific mAb with an enhanced incidence of monogamous binding to mIgM was ineffective at inducing B cell DNA synthesis, the antibody was not significantly compromised in ability to initiate inhibitory signals. These differences could be observed in a clonal B cell population which positively or negatively responded to mIgM ligation depending upon its state of activation. The accumulated observations indicate that the ligand binding requisites for inhibitory signal transduction in human B lymphocytes are much less rigorous than those for stimulatory signal transduction and suggest that many physiologically relevant anti-Ig antibodies are more likely to function in the negative feedback regulation of B cell responses than in the direct triggering of human B cell clonal expansion.
Phenotype of asthmatics with increased airway <i>S</i>-nitrosoglutathione reductase activity
Authors: Nadzeya V. Marozkina, Xin-Qun Wang, Vitali Stsiapura, Anne Fitzpatrick, Silvia Carraro, Gregory A. Hawkins, Eugene Bleecker, Deborah Meyers, Nizar Jarjour, Sean B. Fain, Sally Wenzel, William Busse, Mario Castro, Reynold A. Panettieri, Wendy Moore, Stephen J. Lewis, Lisa A. Palmer, Talissa Altes, Eduard E. de Lange, Serpil Erzurum, W. Gerald Teague, Benjamin Gaston
Journal: European Respiratory Journal (2014)

S -Nitrosoglutathione is an endogenous airway smooth muscle relaxant. Increased airway S -nitrosoglutathione breakdown occurs in some asthma patients. We asked whether patients with increased airway catabolism of this molecule had clinical features that distinguished them from other asthma patients. We measured S -nitrosoglutathione reductase expression and activity in bronchoscopy samples taken from 66 subjects in the Severe Asthma Research Program. We also analysed phenotype and genotype data taken from the program as a whole. Airway S -nitrosoglutathione reductase activity was increased in asthma patients (p=0.032). However, only a subpopulation was affected and this subpopulation was not defined by a “severe asthma” diagnosis. Subjects with increased activity were younger, had higher IgE and an earlier onset of symptoms. Consistent with a link between S -nitrosoglutathione biochemistry and atopy: 1) interleukin 13 increased S -nitrosoglutathione reductase expression and 2) subjects with an S -nitrosoglutathione reductase single nucleotide polymorphism previously associated with asthma had higher IgE than those without this single nucleotide polymorphism. Expression was higher in airway epithelium than in smooth muscle and was increased in regions of the asthmatic lung with decreased airflow. An early-onset, allergic phenotype characterises the asthma population with increased S -nitrosoglutathione reductase activity.
Kinin Release after Gastric Surgery
Authors: A. Cuschieri, O. A. Onabanjo
Journal: BMJ (1971)

Kinin studies were performed in six patients with vasomotor dumping after gastric surgery and in six control patients who had had similar surgical procedures without subsequent dumping. Depletion of the precursor, kininogen, was found in all the patients with dumping and increased free plasma kinin activity in four after a 50-g carbohydrate meal which precipitated an attack. No significant changes were found in the control group after a high carbohydrate intake.
SOME PERSONAL EXPERIENCES IN THE USE OF ELECTRICITY IN OPHTHALMIC PRACTICE.
Authors: W. FRANKLIN COLEMAN
Journal: JAMA (1907)

This report will be limited by request to the use of the galvanic and the form of alternating current known as the sinusoidal. That the subject of electricity in ophthalmic practice has received scant attention appears from a statement by the secretary of this section, Dr. Bulson: "For several years the subject has received no consideration. In 1898 Dr. Starkey read a paper on 'The Use of Galvanism in Pterygium,' and Dr. LeMond on 'The Value of Faradism in Choroiditis.' Since then nothing has been presented except some papers on the galvanic cautery and the magnet." It is probably safe to say that there is no remedy which causes so varied physiologic manifestations and therapeutic results as electricity. By proper selection of modality, current strength, tension, polarity, length and frequency of application, etc., stimulation or sedation of the nervous and vasomotor systems, muscular contraction, decomposition and destruction of tissue, changes
Post-mortem CT scan with contrast injection and chest compression to diagnose pulmonary embolism
Authors: Claire Pichereau, Eric Maury, Laurence Monnier-Cholley, Simon Bourcier, Gabriel Lejour, Mikael Alves, Jean-Luc Baudel, Hafid Ait Oufella, Bertrand Guidet, Lionel Arrivé
Journal: Intensive Care Medicine (2014)
To Hydrate or Not to Hydrate: How Should It Be?
Authors: Eduardo Bruera, Neil MacDonald
Journal: Journal of Clinical Oncology (2000)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.5.1156 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10694570 To Hydrate or Not to Hydrate: How Should It Be? Eduardo BrueraxEduardo BrueraSearch for articles by this author , Neil MacDonaldxNeil MacDonaldSearch for articles by this author https://doi.org/10.1200/JCO.2000.18.5.1156 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical Oncology