tbuckley/cabot-search huggingface dataset:
Triiodothyronine alters the cornification of cultured human keratinocytes
Authors: R.R. ISSEROFF, K.T. CHUN, R.M. ROSENBERG
Journal: British Journal of Dermatology (1989)

Scaly skin occurs in 80‐90% of patients who are hypothyroid, the pathogenesis of which is unknown. Since thyroid hormone (T3) affects growth and differentiation in other organs, we examined the effects of its absence on keratinocytes in vitro. Human neonatal foreskin keratinocytes were cultivated and second passage cells were switched to T3‐depleted (–T3) medium at 50% confluence. Cells maintained in the –T3 medium demonstrated increased (1.5 fold) levels of the cross‐linking enzyme transglutaminase and increased (1.5 fold) formation of cornified envelopes, when compared to keratinocytes maintained in medium containing physiologic levels (2 × 10−9 M) of T3. Additionally, in the –T3 cultures, the level of the protease plasminogen activator (PA), an enzyme implicated in the process of shedding of cornified cells, was decreased 70‐80% of that measured in +T3 media. Absence of T3 from keratinocyte culture‐medium increased both the level of the enzyme responsible for cross‐linking cornified envelope precursors and the rate of envelope formation in cultured cells. The decreased levels of PA observed in the –T3 cultures could result in decreased shedding of cornified cells. These alterations in the process of keratinocyte differentiation may explain the clinically observed scaliness associated with hypothyroidism in humans. The molecular mechanism by which T3 alters keratinocyte cornification is not yet known.
Effects of chronic sunlight exposure on the immunological function of the human epidermis
Authors: J. Peguet-Nvarro, J. Viac, A. Gueniche, F.-M. Ratis, C. Larner, A. Claudy, D. Schmitt
Journal: British Journal of Dermatology (1995)

Journal Article Effects of chronic sunlight exposure on the immunological function of the human epidermis Get access J. Peguet‐Nvarro, J. Peguet‐Nvarro INSERM U 346, Pavillion R, Hopital E. Herriot, 69437, Lyon 03, France Search for other works by this author on: Oxford Academic Google Scholar J. Viac, J. Viac INSERM U 346, Pavillion R, Hopital E. Herriot, 69437, Lyon 03, France Search for other works by this author on: Oxford Academic Google Scholar A. Gueniche, A. Gueniche INSERM U 346, Pavillion R, Hopital E. Herriot, 69437, Lyon 03, France Search for other works by this author on: Oxford Academic Google Scholar F.‐M. Ratis, F.‐M. Ratis INSERM U 346, Pavillion R, Hopital E. Herriot, 69437, Lyon 03, France Search for other works by this author on: Oxford Academic Google Scholar C. Larner, C. Larner Produits Roche, 52, boulevard du Parc, 92521, Neuilly/Seine, France Search for other works by this author on: Oxford Academic Google Scholar A. Claudy, A. Claudy PECLIC Pavillion R, Hospital E. Herriot, 69437, Lyon 03, France Search for other works by this author on: Oxford Academic Google Scholar D. Schmitt D. Schmitt INSERM U 346, Pavillion R, Hopital E. Herriot, 69437, Lyon 03, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 4, 1 October 1995, Pages 660–661, https://doi.org/10.1111/j.1365-2133.1995.tb02729.x Published: 01 October 1995
Emergency Coloscopy in the Management of the Acute Peranal Hemorrhage
Authors: P. Deyhle, A. Blum, H. Nüesch, S. Jenny
Journal: Endoscopy (1974)

It is difficult to locate sources of acute hemorrhage in the colon. Angiography has hitherto been the leading diagnostic method, providing positive results in about 60% of cases. With coloscopy in 17 out of 18 suspected cases of acute hemorrhage from the colon the source of bleeding could either be accurately located (15 cases) or excluded (2 cases). In only one case, when the hemorrhage was associated with diverticular disease, could the bleeding diverticulum not be identified. Endoscopy provides not only a method of locating the source of the hemorrhage but also the nature of this and thus helps to decide the type of treatment. Furthermore, it is also possible to treat a hemorrhagic source by endoscopic techniques in special cases. Coloscopy is in our experience the method of choice in the diagnosis of acute hemorrhage from the colon.
The Immunology Series Comes to an End
Authors: Fred S. Rosen, Ian Mackay
Journal: New England Journal of Medicine (2001)

The thought-provoking article by Zinkernagel in this issue of the Journal 1 brings to a close the series of review articles on immunology that have been appearing in these pages during the past 17 months. Those who have read these reviews will conclude that extraordinary progress has been made in this field in recent decades but also that the major clinical problems of allergy, autoimmunity, and inflammation remain unsolved. We have reached a point at which advances in immunology and genetics should explain what causes the immune system to respond at times by damaging normal tissues instead of eliminating an invading . . .
P514Towards cell-specific targeting of proteasomes in vascular cells
Authors: S Wieber, BI Florea, AH Wagner, HS Overkleeft, M Hecker, O Drews
Journal: Cardiovascular Research (2014)

Introduction: Within the past decade, it has been demonstrated that the outcome of multiple cardiovascular diseases can be modulated via the proteasome, which is already a target of cancer chemotherapeutics. However, the proteasome is a heterogenous group of multi-protein complexes and their precise assembly in vascular cells remains unknown. Therefrore, aim of the study was to map the functional subproteome of 20S proteasome complexes in vascular cells in detail. Methods and Results: Proteasome complexes of cell lysates as well as intact cells were analyzed based on the covalent binding of fluorescent inhibitors, which target only active proteolytic subunits in fully assembled 20S proteasomes. Application of both approaches revealed the existence of an unanticipated proteasome heterogeneity in human vascular and blood-derived cells with a mixed assembly of constitutive and inducible proteasomal subunits even under baseline conditions. Remarkably, the ratio of constitutive to inducible proteasomal subunits allowed to differentiate between the cells. The results obtained via living cell targeting showed that the highest abundance of functional, inducible subunits exists in lymphocytes (LC) and monocytes (MC) followed by platelets (Plt) and endothelial cells (EC), and was minimal in smooth muscle cells (SMC) (e.g. subunit β5i +50% in MC vs. EC, +90% in MC vs. SMC, p<0.01, n=4-8). On the other hand, the functional constitutive counterparts of the inducible proteolytic subunits were most abundant in EC and least abundant in Plt (e.g. subunit β5 +75% in EC vs. MC, +85% in EC vs. LC, + 90% in EC vs. Plt, p<0.01, n=4-8). Notably, the overall abundance of functional proteasome complexes was cell-type dependent as well. Thus, incorporation of proteolytic subunits in active 20S proteasomes was a function of subunits targeted by the fluorescent inhibitors and proteasome concentration in the cell. To validate the results obtained for EC and SMC under cell culture conditions, murine aortae were perfused with the fluorescent inhibitors. Fluorescence microscopy confirmed tissue penetration of the fluorescent inhibitors into the intima, media and adventitia, thus enabling a highly specific staining of active proteolytic subunits of the proteasome, whereby the proteasome assembly in the tissue matched that of cultured cells. Conclusion: Proteasome assembly is characteristic among vascular cells predicting an opportunity for a cell-directed proteasome targeting not only in the pathology of blood-borne cancer, but also in cardiovascular disorders.
Definitive Diagnosis of Obstructed Total Anomalous Pulmonary Venous Drainage in a Critically Ill Newborn With High-Resolution Computed Tomography
Authors: Phalla Ou, David S. Celermajer, Bertrand Stos, Eloi Marijon, Pascal Vouhé, Francis Brunelle, Damien Bonnet, Daniel Sidi
Journal: Circulation (2006)
“Hyper-Thyroiditis” — A Diagnostic Pitfall
Authors: Ivor M.D. Jackson
Journal: New England Journal of Medicine (1975)

Subacute thyroiditis is an acute, subacute or chronic, generalized, self-limiting, nonbacterial, inflammation of the thyroid. Characteristic histologic findings include giant cells, granulomas and pseudotubercles. Characteristically, the thyroid gland is enlarged, painful and tender. The local pain may radiate to the jaw or ear, and there may be systemic manifestations of fever, malaise, and aches in muscles and joints. In at least 50 per cent of cases a hypermetabolic state suggestive of thyrotoxicosis is present, and measurement of circulating thyroid hormones will often demonstrate increased levels of thyroxine and tri-iodothyronine. However, unlike classic thyrotoxicosis, the radioactive iodine (131I) uptake is . . .
Intracoronary thrombolysis to abort heart attacks: Wave of the future?
Authors: Elizabeth Rasche González
Journal: JAMA (1981)

The audience emitted a collective gasp. On a movie screen in front of them, a nasty clot was high-tailing it through a coronary artery. Within about 30 s, the clot had dissolved. The man who had caused the clot lysis—William Ganz, MD, professor of medicine at UCLA and senior research scientist, Cedars-Sinai Medical Center, Los Angeles—modestly denied "planning" the event that his extraordinary film footage captured so that it would occur at that precise moment. There is no clinical marker for mobilization of the thrombus, he said, but generally it<i>will</i>get going if you infuse a thrombolytic agent as close to its exact location as possible. Ganz and colleagues use a standard catheter through which they advance a special soft catheter (diameter, 0.022 in) to the site of the clot. They then infuse Thrombolysin (a combination of streptokinase and plasminogen) through the special catheter at a dosage of 2,000
<i>Child Protection Companion</i> : editorial group's reply to royal college rewriting history
Authors: Jean Price, Chris Hobbs, Jacqueline Mok, Alison Mott, Margaret Crawford, Sara Ghulam
Journal: BMJ (2006)

EDITOR—Gornall is correct to raise the issue of Roy Meadow's and David Southall's omission from the reference list in the Child Protection Companion .12 Southall, along with others, made contributions to the sections on fabricated and induced illness and imposed airway obstruction in chapter 6 of the Companion . Considerable notice was taken of Southall's views on these topics.

The editorial group discussed how to manage the references throughout the book and, for these sections, chose to reference only the two documents on fabricated and induced illness produced by the Royal College of Paediatrics and Child Health (2002) and the Department of Health …
Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung
Authors: Corinna Pfeifer, Guenther Hasenpusch, Senta Uezguen, Manish Kumar Aneja, Dietrich Reinhardt, Julian Kirch, Marc Schneider, Sarah Claus, Wolfgang Frieß, Carsten Rudolph
Journal: Journal of Controlled Release (2011)
Treatment Services at a Mental Hospital in Transition
Authors: HERBERT C. SCHULBERG, RALPH NOTMAN, EDWARD BOOKIN
Journal: American Journal of Psychiatry (1967)

A survey of the treatment program at a large mental hospital indicated that with a redeployment of services, the number of patients uninvolved in any specific treatment was reduced by 50 percent. The change was related primarily to greater use of drugs, although verbal treatments also increased. Patient characteristics associated with treatment pattern are described.
"PERNICIOUS ANEMIA AND TUBERCULOSIS"
Authors: Alexander Josewich
Journal: JAMA (1933)

To the Editor:  —On reading Dr. Moses Barron's article inThe Journal, May 20, one is left in doubt as to whether the conclusions reached in this study contribute as much to the consideration of this question as could be expected. Dr. Barron does not tell the number of tuberculosis cases present in this series of over 16,000 postmortem examinations, nor does he tell how careful a search was made to determine the actual existence of pernicious anemia in all the bodies examined. It is obvious, however, that over 2 per cent of the bodies examined and found to have pernicious anemia also showed active tuberculosis. It would be of value to know whether more than 330 cases of active tuberculosis were encountered in the whole series. One would like to know just what the incidence of pernicious anemia is in the general run of patients encountered in the general
Cardiotocographs at a distance.
Authors: P. J. Steer, M. C. Carter
Journal: BMJ (1989)

work is to cease.With the cost of surgical footwear at more than £15m a year, the difficulties in recruitment of skilled shoemakers, and the delays that cause such dissatisfaction, this policy can only be described as staggeringly shortsighted.Any bioengineering development of this sort is expensive, but it is also vital if Britain is to maintain any kind of position in this specialty.The proposed devolvement of responsibility to regional health authorities makes the future look even bleaker.
WHO in retreat: is it losing its influence?
Authors: F. Godlee
Journal: BMJ (1994)

WHO says it has three main functions: to set normative standards; to provide technical advice and assistance on medical matters; and to advocate changes in health policy. During its 46 year history the first two functions have been a constant and uncontroversial backbone through which WHO has earned its reputation for scientific excellence. The third function, advocacy, came to the fore with the launch of Health for All in 1977, after which WHO took a key role in influencing international health policy. WHO's friends and critics alike now say that the organisation is losing its influence and retreating into its technical and biomedical shell. This article maps the changes in WHO's approach over the past 46 years and considers whether fears about its loss of influence are justified.
Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities
Authors: Mariella Gruber Filbin, Sukriti K Dabral, Maria F Pazyra-Murphy, Shakti Ramkissoon, Andrew L Kung, Ekaterina Pak, Jarom Chung, Matthew A Theisen, Yanping Sun, Yoko Franchetti, Yu Sun, David S Shulman, Navid Redjal, Barbara Tabak, Rameen Beroukhim, Qi Wang, Jean Zhao, Marion Dorsch, Silvia Buonamici, Keith L Ligon, Joseph F Kelleher, Rosalind A Segal
Journal: Nature Medicine (2013)
An Update on the Vitamin D Content of Fortified Milk from the United States and Canada
Authors: Tai C. Chen, Qing Shao, Hunter Heath, Michael F. Holick
Journal: New England Journal of Medicine (1993)

To the Editor: We reported previously (April 30, 1992, issue)1 that 71 percent of 42 milk samples purchased in five Eastern states in 1991 did not contain 80 to 120 percent of the amount of vitamin D claimed on the label. These results confirmed an earlier study by the Food and Drug Administration (FDA)2. As a result of these observations, there has been increased awareness of the need to monitor the fortification of milk with vitamin D more carefully. Between May 1992 and June 1993, we therefore purchased 94 milk samples in seven Eastern states, including the same five . . .
Tuberculosis Care: When and Where?
Authors: LEE B. REICHMAN
Journal: Annals of Internal Medicine (1974)

Modem medical management of tuberculosis is widely accepted and practiced; however, beyond medical methods and principles, the attitudes of the medical professionals and lay persons alike reflect long-standing, unwarranted fear rather than true scientific thinking. This is mainly because tuberculosis has always been and often still is handled outside the mainstream of medical care. Much specific research and even more circumstantial evidence dictate that tuberculosis is spread mainly before diagnosis, so that hospitalization usually is unnecessary to protect contacts; is spread mainly by droplet aerosol from an untreated patient, so that gowns and most isolation procedures provide a false, unnecessary security; can be treated efficiently in an outpatient setting, so routine hospitalization is unnecessary for treatment; and becomes noninfectious rapidly, so most patients can return to work quickly. Unfortunately, most of these advances are not accepted by practicing physicians and public health officials. Except for the advent of drugs, tuberculosis is now treated emotionally, as it was in the last century.
Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor.
Authors: C Bilato, R R Pauly, G Melillo, R Monticone, D Gorelick-Feldman, Y A Gluzband, S J Sollott, B Ziman, E G Lakatta, M T Crow
Journal: Journal of Clinical Investigation (1995)

Intracellular signaling pathways activated by both PDGF and basic fibroblast growth factor (bFGF) have been implicated in the migration of vascular smooth muscle cells (VSMC), a key step in the pathogenesis of many vascular diseases. We demonstrate here that, while bFGF is a weak chemoattractant for VSMCs, it is required for the PDGF-directed migration of VSMCs and the activation of calcium/calmodulin-dependent protein kinase II (CamKinase II), an intracellular event that we have previously shown to be important in the regulation of VSMC migration. Neutralizing antibodies to bFGF caused a dramatic reduction in the size of the intracellular calcium transient normally seen after PDGF stimulation and inhibited both PDGF-directed VSMC migration and CamKinase II activation. Partially restoring the calcium transient with ionomycin restored migration and CamKinase II activation as did the forced expression of a mutant CamKinase II that had been "locked" in the active state by site-directed mutagenesis. These results suggest that bFGF links PDGF receptor stimulation to changes in intracellular calcium and CamKinase II activation, reinforcing the central role played by CamKinase II in regulating VSMC migration.
Unwarranted referral of relatives
Authors: G H Pitt
Journal: BMJ (1989)

group of fit 29 year old men.The slight reductions in protein synthesis in the patients with myalgic encephalomyelitis might well be explained by the differences in age, sex, and body build between the control and study groups.In addition, since there was no evidence of muscle wasting in the patients it follows that protein degradation was reduced to the same degree as protein synthesis.We have studied patients with muscle pain and weakness, many of whom dated the onset of their
Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart
Authors: Kirsten Leineweber, Thekla Wangemann, Christine Giessler, Heike Bruck, Stefan Dhein, Martin Kostelka, Friedrich-Wilhelm Mohr, Rolf-Edgar Silber, Otto-Erich Brodde
Journal: Journal of the American College of Cardiology (2002)
Litigation for medical malpractice has failed to improve patient care, hears conference
Authors: R. Coombes
Journal: BMJ (2010)

Pursuing doctors for compensation through the courts when errors occur can amount to “torture” for the professional concerned and does not improve patient care, a safety conference heard.

In a debate on whether litigation improves patient care, Shelia McLean, chair of law and ethics in medicine at Glasgow University, said that the United Kingdom’s adversarial system had failed. She was speaking at Risky Business, a conference on patient safety hosted by Great Ormond Street Hospital for Children and supported by the BMJ .

Professor McLean, who has been investigating the possibility of introducing a no fault compensation scheme in Scotland, said, “Studies show that most patients want a meaningful apology, a meaningful explanation, and an assurance that policies have changed. Very …
“Drink plenty of fluids”: Argument was not convincing
Authors: Yiu Wing Cheung
Journal: BMJ (2004)

Editor—I am not convinced by the paper by Guppy et al that drinking fluid is harmful to all patients with respiratory infection.1 Thinking that increased secretion of antidiuretic hormone secretion in infections of the lower respiratory tract is a common phenomenon is not correct. Hyponatraemia is a well known complication of infections of the lower respiratory tract, but it is not common.

Furthermore, it is difficult to prove whether the incidence or the death of patients with hyponatraemia related to infections of the lower respiratory tract was associated with increased water intake. Hyponatraemia could still occur even with normal fluid intake.

Fluid restriction may not be helpful to all infections of the lower respiratory tract. To restrict fluid to the extent of causing dehydration may even be harmful. The authors' data cannot be extrapolated to patients with upper respiratory infection because there was no definite evidence. In Hong Kong the newspapers quoted the study and said that plenty of fluid in flu can be harmful. I worry that the community might have a misconception about the findings of this study.
SPINAL ANESTHESIA IN GYNECOLOGY, OBSTETRICS AND ABDOMINAL SURGERY
Authors: W. WAYNE BABCOCK
Journal: JAMA (1913)

In 1885 Dr. J. Leonard Corning<sup>1</sup>of New York published the first article onspinal anesthesia. Not considering it feasible to introduce the solution within the arachnoid, Dr. Corning injected a solution of cocain between the spinous processes in the lower dorsal region of a man and a dog. Although in both instances there were evidences of anesthesia, and although Dr. Corning considered the feasibility of operating under this method, nearly fifteen years elapsed before August Bier at Bonn, Germany, first produced intradural anesthesia. Bier had the experiment made on himself and later injected his assistant, an example of medical herosim that recalls Sir James Y. Simpson's demonstration of the anesthetic value of Chloroform. Despite the warning from Bier, the intradural injection was promptly tried in many of the clinics of the world but soon was abandoned from imperfections in the technic and disadvantages attending the use of cocain. In 1902, with the discovery of a series of synthetic alkaloid-like bodies having local analgesic properties, the method was revived and came into larger use. Of these substances,
Alton Ochsner: Biographical Materials
Authors: IRA HARKEY
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 February 1977Alton Ochsner: Biographical MaterialsIRA HARKEY, PH.D.IRA HARKEY, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-247_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: For a biography of Dr. Alton Ochsner of Ochsner Clinic, New Orleans, opinions, evaluations, anecdotes, reminiscences, and photographs are needed. Photographs will be carefully handled and returned. All material gratefully received by me.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 401 Metairie Road, 706 Metairie, LA 70005 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1977Volume 86, Issue 2Page: 247-247 ePublished: 1 December 2008 Issue Published: 1 February 1977 PDF downloadLoading ...