tbuckley/cabot-search huggingface dataset:
Rapid downregulation of rat renal Na/Pi cotransporter in response to parathyroid hormone involves microtubule rearrangement
Authors: Marius Lötscher, Yvonne Scarpetta, Moshe Levi, Nabil Halaihel, Huamin Wang, Hubert K. Zajicek, Jürg Biber, Heini Murer, Brigitte Kaissling
Journal: Journal of Clinical Investigation (1999)

Renal proximal tubule cells express in their apical brush border membrane (BBM) a Na/Pi cotransporter type IIa that is rapidly downregulated in response to parathyroid hormone (PTH). We used the rat renal Na/Pi cotransporter type IIa (NaPi-2) as an in vivo model to assess early cellular events in the rapid downregulation of this transporter. When rats were treated with PTH for 15 minutes, NaPi-2 abundance in the BBM was decreased. In parallel, transporter accumulated in intracellular vesicles. Concomitantly, microtubules (MTs) were found to form dense bundles of apical-to-basal orientation. After 60 minutes of PTH action, the cells were vastly depleted of NaPi-2, whereas their microtubular cytoskeleton had returned to its normal appearance. Prevention of MT rearrangement by taxol resulted in accumulation of NaPi-2 in the subapical cell portion after 15 minutes and a strong delay in depletion of intracellular transporter after 60 minutes of PTH action. Furthermore, the subapical accumulation of NaPi-2 was associated with the expansion of dense apical tubules of the subapical endocytic apparatus (SEA). Depolymerization of MTs by colchicine likewise caused a retardation of intracellular NaPi-2 depletion. These results suggest that NaPi-2 is downregulated in response to PTH through a rapid endocytic process in 2 separate steps: (a) internalization of the transporter into the SEA, and (b) its delivery to degradative organelles by a trafficking mechanism whose efficiency depends on a taxol-sensitive rearrangement of MTs.
Fasting, Feeding and Regulation of the Sympathetic Nervous System
Authors: Lewis Landsberg, James B. Young
Journal: New England Journal of Medicine (1978)

THE importance of catecholamines in the regulation of metabolic processes has been recognized for over 50 years. Catecholamines influence metabolism in two major ways: they increase the rate of cellular metabolism,1 2 3 4 and they stimulate the conversion of complex fuels into readily usable substrates.5 The increased rate of cellular metabolism induced by catecholamines is manifested by elevations in heat production and fuel and oxygen consumption; however, the cellular mechanisms involved have not been established, and this important effect of catecholamines on energy consumption is often overlooked. Catecholamine stimulation of the breakdown of complex fuels supplies energy for increased cellular metabolism; the . . .
Will Targeting Chk1 Have a Role in the Future of Cancer Therapy?
Authors: Nandini Sakurikar, Alan Eastman
Journal: Journal of Clinical Oncology (2015)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2014.60.0767 Journal of Clinical Oncology - published online before print February 17, 2015 PMID: 25691674 Will Targeting Chk1 Have a Role in the Future of Cancer Therapy? Nandini SakurikarxNandini SakurikarSearch for articles by this author , Alan EastmanxAlan EastmanSearch for articles by this author Show More Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH https://doi.org/10.1200/JCO.2014.60.0767 First Page Full Text PDF Figures and Tables © 2015 by American Society of Clinical Oncology
Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF-independent suppression of Erk1/2 activation and Egr-1–mediated transcriptional events
Authors: Jai-Hyun Kim, Dong Soon Choi, Ok-Hee Lee, Seung-Hyun Oh, Scott M. Lippman, Ho-Young Lee
Journal: Blood (2011)
A fifth of elderly people in Israel are abused
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2005)

Israel's first national survey of elder abuse has said that 18.4% of elderly people reported being abused in the previous year. Rates of neglect were among the highest in the world, while rates of physical and sexual abuse and limitation of freedom were similar to those in North America, the United Kingdom, Australia, and Hong Kong. Economic exploitation and verbal violence were more common in Israel than in many of those countries.

The types of abuse were neglect (18.0%); verbal (8.0%) or physical or sexual abuse (2.0%); limitation of freedom (2.7%), or economic exploitation (6.6%) by a spouse or adult child. Some people had been abused in more …
Unrelated peripheral blood and cord blood hematopoietic stem cell transplants for thalassemia major
Authors: Patrick Huat‐Chye Tan, William Ying Khee Hwang, Yeow Tee Goh, Poh Lin Tan, Liang Piu Koh, Cheng Hoe Tan, Thuan Chong Quah
Journal: American Journal of Hematology (2004)

Abstract Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment available for thalassemia major. While sibling donors are usually used, unrelated bone marrow transplants have also recently been found to be successful. In this report of two patients, we show that, besides using unrelated bone marrow, peripheral blood stem cell and cord blood transplantations from unrelated donors are viable options. We believe a significant contributory factor in both our cases was the large cell dose used. Am. J. Hematol. 75:209–212, 2004. © 2004 Wiley‐Liss, Inc.
Imipenem: Interpretation of a Table
Authors: MICHAEL BARZA
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 March 1986Imipenem: Interpretation of a TableMICHAEL BARZA, M.D.MICHAEL BARZA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-449_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The ellipses marks (. . .) in Table 1 of my article in the October issue (1) shouldnotbe misinterpreted to mean that the drug had no activity. The symbols are used in the table to indicate that no entry was being made in that column of data....Reference1. BARZA M. Imipenem: first of a new class of beta-lactam antibiotics. Ann Intern Med. 1985;103:552-60. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tufts University School of Medicine New England Medical Center Hospitals Boston, MA 02111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1986Volume 104, Issue 3Page: 449-449KeywordsDrugs Issue Published: 1 March 1986 PDF DownloadLoading ...
Synthetic peptide vaccine confers protection against murine malaria.
Authors: F Zavala, J P Tam, P J Barr, P J Romero, V Ley, R S Nussenzweig, V Nussenzweig
Journal: The Journal of Experimental Medicine (1987)

A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoites.
SEPARATION OF NORMAL AND IMMUNE LYMPHOID CELLS BY ANTIGEN-COATED COLUMNS
Authors: H. Wigzell, O. Mäkelä
Journal: The Journal of Experimental Medicine (1970)

Specific fractionation of immunologically competent cells derived from normal or immune animals was achieved by filtration through antigen-coated bead columns. This selective retention of the relevant reactive cells could be shown to produce a cell population, which after passage through the column would behave like a suspension rendered immunologically tolerant by "classical" means. The immunologically specific elimination of potential antibody-forming capacity of the filtered cells could be shown to affect the IgM and the IgG system to a similar extent. Analysis of the binding characteristics of the membrane antibodies responsible for this selective retention indicate striking similarities to those of the humoral antibodies produced against the antigen. Thus, the surface receptor could distinguish isolated haptenic groups on a "foreign" carrier background and the receptor of the hapten-reactive cells in the present system (high-rate antibody-forming cells against NIP) failed to combine with carrier specific determinants in analogy with the binding behavior of the serum anti-hapten antibodies. The binding of anti-hapten reactive cells to bead-attached haptens could be specifically inhibited by the presence of free hapten in the columnar fluid during cellular filtration. The results strongly suggest that the potential humoral antibody-forming cell has preformed receptors on its outer surface with binding characteristics, indicating similarity, if not identity, to those of the eventual product of the cell, the humoral antibody.
Cause-specific mortality in patients with severe psoriasis
Authors: S.R. Feldman
Journal: British Journal of Dermatology (2010)

Conflicts of interest S.R.F. has received research, speaking and/or consulting support from Abbott, Amgen, Astellas, Centocor, Galderma, GSK/Stiefel, and National Biological Corporation. Psoriasis is a complex, immune‐mediated condition with broad effects on patients’ lives. The increased risks of serious comorbidities that have been identified in patients with psoriasis add to the complexity.1 Psoriasis management involves more than just making the diagnosis and prescribing an ointment. Recognition of the broad effects of psoriasis on patients’ quality of life necessitates addressing the psychosocial issues.2 Patients may feel untouchable and isolated; palpating the lesions is an important component of the treatment process that can help heal psychological scars. It is also critically important that dermatologists project to patients a caring attitude; patients’ perceptions of their doctors’ caring attitude largely determines patient satisfaction and, most likely, adherence to recommended treatment.3 Comprehensive management should also include an assessment of joint symptoms – joint pain, joint stiffness and back pain – that may indicate the presence of psoriatic arthritis.4 The recognition of a higher risk of cardiovascular disease and malignancy should encourage queries for and mitigation of other risk factors. The risks should be put into appropriate perspective for patients. Patients hearing there is a threefold increased risk of a lymphoma or myocardial infarction may be terrified.1, 5–7 They should be informed that if their baseline risk is low, a threefold increased risk may not mean much.
Reporting of fine needle aspiration.
Authors: M Nayagam, J M McCutcheon, A E Young
Journal: BMJ (1991)

results comparable to and in some ways superior to more traditional forms of care (W D Savage and R M Cochrane, Nivel international conference on primary care obstetrics and perinatal health, s'Hertogenbosch, 1991).We accept that such a scheme, in which hospital specialists visit local surgeries during their antenatal clinics and in which women therefore need not attend hospital at all, would be inappropriate in some areas.Nevertheless, some may wish to emulate the idea for the benefits outlined above and for the fruitful interprofessional respect that such care engenders.
Do you shake hands with mothers of floppy babies?
Authors: T H Koh
Journal: BMJ (1984)

There are very few clinical situations where the birth of a child can lead to the new diagnosis of a serious condition in the mother and her family. In the past year our unit has had two admissions which resulted in the diagnosis of myotonic dystrophy in both babies and 12 members of their families. I describe one of these two babies in whom routine handshaking with the mother led to an early diagnosis.
Effect of oral continuous progestogen therapy in microdosage on human ovary and sperm transport.
Authors: J. Zanartu, M. Pupkin, D. Rosenberg, R. Guerrero, R. Rodriguez-Bravo, M. Garcia-Huidobro, J. A. Puga
Journal: BMJ (1968)

MkMCLJOUFAAL method in 11 women; in 13 subjects who claim they used the method correctly apparently the method failed.The method is well tolerated and accepted by subjects who had experienced previous intolerance to conventional oral combined or sequential therapy.Its low cost and ease of administration makes it of interest to developing countries with limited resources for family planning.
Loans for American Students in Foreign Medical Schools
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1979)

The Office of Education of the Department of Health, Education, and Welfare is proposing new regulations for determining whether medical schools located outside the United States and Canada are eligible to participate in the Guaranteed Student Loan Program.The Commissioner of Education has announced that, for a foreign school to be eligible, at least 95 per cent of its graduates who are United States citizens and who have taken the ECFMG examination for the first time during the most recent two-year period must pass that examination.1 The intent, he explains, is to set up some objective criterion for ascertaining whether . . .
Nonsustained ventricular tachycardia in patients with coronary artery disease: role of electrophysiologic study.
Authors: A E Buxton, F E Marchlinski, B T Flores, J M Miller, J U Doherty, M E Josephson
Journal: Circulation (1987)

Sixty-two consecutive patients with chronic coronary artery disease referred for evaluation of nonsustained ventricular tachycardia (VT) underwent electrophysiologic studies. Sustained VT was induced by one to three ventricular extrastimuli in 28 patients (45%). Therapy was guided by the results of electrophysiologic testing in 44 patients: 19 patients without inducible sustained VT received no antiarrhythmic therapy, and 25 patients with inducible sustained or symptomatic nonsustained VT received therapy guided by the results of electrophysiologic studies. The results of electrophysiologic studies were ignored by physicians for a second group of 18 patients: four had inducible sustained VT but received no antiarrhythmic therapy, and 14 had inducible sustained or nonsustained VT and received antiarrhythmic therapy not guided by results of electrophysiologic testing. After a mean follow-up period of 28 months, 11 patients had died suddenly. Seven of the 11 patients who died suddenly had inducible sustained VT. Three of 44 patients in the group receiving therapy guided by electrophysiologic studies died suddenly versus eight of 18 in the group receiving therapy not guided by electrophysiologic studies (p = .001). Only one of 19 patients without inducible sustained VT who were not treated experienced sudden death. Two of four patients with inducible sustained VT who did not receive antiarrhythmic therapy died suddenly. Multivariate analysis of the relationship of induced arrhythmias, left ventricular ejection fraction, site of myocardial infarction, history of syncope, or type of antiarrhythmic therapy to outcome revealed a greater than twofold increased risk for sudden cardiac death in patients whose therapy was not guided by results of electrophysiologic study.(ABSTRACT TRUNCATED AT 250 WORDS)
Book: Houdini's Box: On the Arts of Escape
Authors: R. Persaud
Journal: BMJ (2001)

Adam Phillips Faber and Faber, £9.99, pp 176 ISBN 0 571 20620 4 Rating: ![Graphic][1]</img>![Graphic][2]</img> Adam Phillips, a psychotherapist in private practice in London, has written a readable and thought provoking short treatise on the notion of escape. He argues that much of our behaviour can be properly understood only as reflecting an unconscious desire to run away from something that we want to avoid in our lives. Using a factual account of the life of Houdini as a way of … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
P330Overexpression of the muscle specific chaperone Melusin delays heart failure and mortality in a mouse model of Emery Dreyfus cardiomyopathy
Authors: G Tarone, J Cimino, C Rubinetto, E Moiso, F Cristofani, L Zentilin, M Giacca, G Bonne, M Brancaccio
Journal: Cardiovascular Research (2014)

Purpose. Familial cardiomyopathies are caused by genetic mutations that induce accumulation of misfolded proteins with consequent cardiomyocyte death and maladaptive cardiac remodelling. Molecular chaperones are a family of proteins devoted to prevent accumulation of misfolded proteins by promoting either their refolding or degradation via the ubiquitin-proteasome or the autophagosome systems and can thus represent a potential mean to treat familial cardiomyopathies. Methods. Melusin is a muscle specific chaperone protein whose overexpression effectively prevents maladaptive cardiac remodeling and heart failure both in pressure overload and myocardial infarct mouse models. In this study we use in vivo gene delivery with cardiotropic adeno associated virus 9 vector to induce to increase melusin expression in the heart of mice carrying H222P Lamin A mutation mimicking human Emery-Dreifuss familial cardiomyopathy. Mutant male mice develop spontaneous dilated cardiomyopathy from 4 months of age and die within 10-12 months of age. Results. Homozygous mutant mice were injected with AAV9-Melusin (I.V. injection of 1012 viral particles/mouse) either at 1 month of age before development of the cardiomyopathy or at 4 months when cardiomyopathy was already present to test for both preventive and therapeutic activity. Cardiac function was monitored by echocardiography for the following months. While untreated mice progressively developed left ventricle dilation and reduced contractility (FS%), mice injected with AAV9-Melusin retained physiological level of contractility and were protected toward LV dilation. Ten months after the treatment, 40% of mutant mice died, while 100% of melusin-treated mice were alive. A second group of mutant male mice was injected with AAV9-melusin at 4 months of age when the cardiomyopathy was already detectable. Interestingly melusin prevented the deterioration of contractility in the following 6 months and significantly reduced mortality. Conclusions These data indicate that melusin chaperone overexpression can effectively delay the onset of Emery-Dreifuss cardiomyopathy as well as arrest the progression of the already established pathology.
Garlic Breath Odor
Authors: Ronald F. Buchan
Journal: JAMA (1974)

<h3>To the Editor.—</h3> A query inThe Journalregarding garlic-like breath odor in a laboratory technician was answered by your consultant with reference to certain exogenous and endogenous causes, and quite correctly, as far as he went (226:1127, 1973). Aside from garlic itself, however, the commonest source of garlic odor in expired air is exposure to selenium and tellurium in their various forms. A laboratory technician might well have exposure to such compounds, and also possibly in lipstick, if the technician is a woman. Inhalation or cutaneous absorption are common portals of entry. Habitual exposure to extremely small concentrations can cause nausea, vomiting (sudden and explosive), pharyngitis, lethargy, and the telltale garlic breath. Contact dermatitis is not uncommon. Acute intoxications also produce decerebrate central nervous system phenomena with convulsions. Death is a distinct possibility. Certain shampoos obtainable without prescription contain selenium salts, which are effective antiseborrheics. Garlic breath is frequently
Reserpine and Breast Cancer: A Perspective
Authors: Hershel Jick
Journal: JAMA (1975)

The possibility of a connection between reserpine and cancer of the female breast is currently the subject of much scientific debate and is also causing anxiety and concern among both physicians and patients. The origin of this debate and concern was the publication of three studies—conducted in the United States, Britain, and Finland—that pointed to a statistical association between reserpine use and breast cancer.<sup>1-3</sup> The first study was suggested by data from a general purpose survey designed to assess possible relationships of many commonly used drugs to a variety of illnesses. The data came from patients hospitalized in the Boston area. The other two studies, prompted by the Boston findings, were specifically designed to determine whether or not a relationship existed between reserpine-like drugs and breast cancer. The designs of these studies have been criticized, especially selections of the control series.<sup>4</sup>However, such criticisms seem unjustified in the
Medicolegal Rounds. Leading cases
Authors: B. Nortell
Journal: JAMA (1977)

EVERY week there are many court decisions that have an impact on the practice of medicine. These decisions are currently reported, in summary, in The Citation, a newsletter published twice a month by the office of the General Counsel, American Medical Association. Some of these decisions are of such special importance that they deserve the wider publicity that can be obtained through the pages ofThe Journal. Trial court decisions, which are of little precedent value and are subject to reversal, are omitted. Selected decisions are usually restricted to those of the highest state or federal court. It should be remembered, however, that a decision by a court in one state is not necessarily binding elsewhere. <h3>Medical Examinations and Patient's Attorney</h3> The Wisconsin Supreme Court has held that a patient's attorney may be present at an independent medical examination of the patient, at the discretion of the trial court.<sup>1</sup>
A DOUBLE LUMEN IN A HUMAN FALLOPIAN TUBE
Authors: Herbert Edmond Metcalf
Journal: JAMA (1918)

The specimen described was given to me by Dr. Will G. Nichols of Fargo, N. D., in response to a request for human material to be used for class work in histology. The tube was serially sectioned, and only on examination of the finished slides was the double nature of the lumen revealed. The patient from whom this tube was taken was operated on for a dislocated and adherent ovary that had caused severe pain at intervals for several years. A year and a half before the present operation her appendix had been removed by another physician as being the cause of the trouble, but the removal afforded no relief. Dr. Nichols operated to break up the adhesions around the ovary, and it was found that the ovary was large and inflamed, as was also the tube on that side. The tube had a decidedly tuberculous appearance when examined microscopically,