Hypersensitivity Myocarditis Associated With Azithromycin Exposure
Authors: Amit Pursnani
Journal: Annals of Internal Medicine (2009)

Letters3 February 2009Hypersensitivity Myocarditis Associated With Azithromycin ExposureAmit Pursnani, MD, Herman Yee, MD, William Slater, MD, and Nitasha Sarswat, MDAmit Pursnani, MDFrom New York University School of Medicine, New York, NY 10016, and Albert Einstein School of Medicine, Bronx, NY 10461., Herman Yee, MDFrom New York University School of Medicine, New York, NY 10016, and Albert Einstein School of Medicine, Bronx, NY 10461., William Slater, MDFrom New York University School of Medicine, New York, NY 10016, and Albert Einstein School of Medicine, Bronx, NY 10461., and Nitasha Sarswat, MDFrom New York University School of Medicine, New York, NY 10016, and Albert Einstein School of Medicine, Bronx, NY 10461.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-3-200902030-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Myocarditis is a mysterious clinical entity that poses diagnostic and therapeutic challenges. It may be caused by a viral infection or be secondary to inflammation from a bacterial, parasitic, or fungal pathogen. Rarely, it can result from a hypersensitivity allergic reaction to an inciting drug.Objective: To report a case of fulminant myocarditis associated with azithromycin exposure.Case Report: A 48-year-old man presented to his internist 3 months before admission with an upper respiratory tract infection and was prescribed a course of azithromycin. Within hours of the first dose of azithromycin, the patient developed fever and a diffuse maculopapular ...References1. Tas S, Simonart T. Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): an update. Dermatology. 2003;206:353-6. [PMID: 12771485] CrossrefMedlineGoogle Scholar2. Sullivan JR, Shear NH. The drug hypersensitivity syndrome: what is the pathogenesis? [Editorial]. Arch Dermatol. 2001;137:357-64. [PMID: 11255340] MedlineGoogle Scholar3. Chikwava KR, Savell VH, Boyd TK. Fatal cephalosporin-induced acute hypersensitivity myocarditis. Pediatr Cardiol. 2006;27:777-80. [PMID: 17111287] CrossrefMedlineGoogle Scholar4. Kounis NG, Zavras GM, Soufras GD, Kitrou MP. Hypersensitivity myocarditis. Ann Allergy. 1989;62:71-4. [PMID: 2645814] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Amit Pursnani, MD; Herman Yee, MD; William Slater, MD; Nitasha Sarswat, MDAffiliations: From New York University School of Medicine, New York, NY 10016, and Albert Einstein School of Medicine, Bronx, NY 10461.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by"Heart in DRESS": Cardiac Manifestations, Treatment and Outcome of Patients with Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: A Systematic ReviewIsolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case reportDiagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position PaperProlonged Extracorporeal Membrane Oxygenation Support In a Patient with Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome-associated Fulminant Myocarditis – A Case Report and Literature ReviewMacrolide Allergic ReactionsPrevalence, risk factors, and mortality outcome in the drug reaction with eosinophilia and systemic symptoms patients with cardiac involvementPostmortem diagnosis of drug-induced anaphylactic death: Kounis syndrome and hypersensitivity myocarditis are the likely culprit in death of severe anaphylactic reactionsDrug reaction with eosinophilia and systemic symptoms syndrome (DRESS) syndrome associated with azithromycin presenting like septic shock: a case reportA review of DRESS-associated myocarditisAzithromycin-Induced Agitation and ChoreoathetosisMiscellaneous antibacterial drugsToxic Epidermal Necrolysis Caused by Pentamidine; Tigecycline-Induced Pancreatitis; Minocycline-Induced Drug Hypersensitivity Syndrome Followed by Autoimmune Sequelae; Fatal Hypersensitivity Myocarditis Associated with Azithromycin; Altered Mental Status Caused by High Levels of Phenytoin; Pseudogout after Polyethylene Glycol Bowel Cleansing; Severe Pseudomembranous Colitis after Moxifloxacin Use: A Case Series 3 February 2009Volume 150, Issue 3Page: 225-226KeywordsBiopsyDrugsEosinophiliaFeversHypersensitivityImmunosuppressivesMyocarditisMyocardiumRashesResearch laboratories ePublished: 3 February 2009 Issue Published: 3 February 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...