tbuckley/cabot-search huggingface dataset:
Fish and Omega-3 Fatty Acid Intake and Risk of Coronary Heart Disease in Women
Authors: Frank B. Hu
Journal: JAMA (2002)

Higher consumption of fish and omega-3 fatty acids has been associated with a lower risk of coronary heart disease (CHD) in men, but limited data are available regarding women.To examine the association between fish and long-chain omega-3 fatty acid consumption and risk of CHD in women.Dietary consumption and follow-up data from 84 688 female nurses enrolled in the Nurses' Health Study, aged 34 to 59 years and free from cardiovascular disease and cancer at baseline in 1980, were compared from validated questionnaires completed in 1980, 1984, 1986, 1990, and 1994.Incident nonfatal myocardial infarction and CHD deaths.During 16 years of follow-up, there were 1513 incident cases of CHD (484 CHD deaths and 1029 nonfatal myocardial infarctions). Compared with women who rarely ate fish (<1 per month), those with a higher intake of fish had a lower risk of CHD. After adjustment for age, smoking, and other cardiovascular risk factors, the multivariable relative risks (RRs) of CHD were 0.79 (95% confidence interval [CI], 0.64-0.97) for fish consumption 1 to 3 times per month, 0.71 (95% CI, 0.58-0.87) for once per week, 0.69 (95% CI, 0.55-0.88) for 2 to 4 times per week, and 0.66 (95% CI, 0.50-0.89) for 5 or more times per week (P for trend =.001). Similarly, women with a higher intake of omega-3 fatty acids had a lower risk of CHD, with multivariable RRs of 1.0, 0.93, 0.78, 0.68, and 0.67 (P<.001 for trend) across quintiles of intake. For fish intake and omega-3 fatty acids, the inverse association appeared to be stronger for CHD deaths (multivariate RR for fish consumption 5 times per week, 0.55 [95% CI, 0.33-0.90] for CHD deaths vs 0.73 [0.51-1.04]) than for nonfatal myocardial infarction.Among women, higher consumption of fish and omega-3 fatty acids is associated with a lower risk of CHD, particularly CHD deaths.
Heart failure and cognitive function in the general population: the Hoorn Study
Authors: Katja van den Hurk, Yael D. Reijmer, Esther van den Berg, Marjan Alssema, Giel Nijpels, Piet J. Kostense, Coen D.A. Stehouwer, Walter J. Paulus, Otto Kamp, Jacqueline M. Dekker, Geert Jan Biessels
Journal: European Journal of Heart Failure (2011)
64 Overexpression of cyclin E2 and liver-fatty acid binding protein in cirrhotic liver is associated with the development of hepatocellular carcinoma in patients with hepatitis C
Authors: A. Lupo, D. Dargere, I. Bieche, V. Paradis, F. Degos, J. Belghiti, P. Bedossa
Journal: Journal of Hepatology (2006)
Abstract 3740: Temozolomide-perillyl alcohol conjugate is cytotoxic for glioma cancer stem cells.
Authors: Niyati Jhaveri, Fabienne Agasse, Florence M. Hofman, Thomas C. Chen
Journal: Cancer Research (2013)

Abstract Glioblastoma multiforme (GBM), the most malignant glioma, is a highly invasive tumor which is usually fatal within 2 years. The chemotherapeutic agent of choice is temozolomide (TMZ); however glioma patients inevitably become resistant to TMZ and tumors recur. Tumor recurrence has been associated with highly invasive, chemoresistant cancer stem cells (CSC) which is resistant to TMZ. We have constructed a new chemical entity by conjugating TMZ to perillyl alcohol (POH) via a carbamate bond. This compound, TMZ-POH, contains POH, a naturally occurring monoterpene that reduces tumor cell migration and has anti-tumor properties against gliomas as well as other cancers. In the studies presented here we demonstrate that TMZ-POH is cytotoxic to CSCs without affecting normal stem cells. The mechanism of TMZ-POH induced cytotoxicity is mediated in part through the DNA damage response pathway and apoptosis. Furthermore, the TMZ-POH conjugate is 5 to 10 fold more effective in inducing cell death compared to TMZ, POH or the mixture of these agents. Our data show that TMZ-POH is a promising novel compound directed against cancer stem cells and therefore important for the treatment of drug resistant, recurrent gliomas. Citation Format: Niyati Jhaveri, Fabienne Agasse, Florence M. Hofman, Thomas C. Chen. Temozolomide-perillyl alcohol conjugate is cytotoxic for glioma cancer stem cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3740. doi:10.1158/1538-7445.AM2013-3740
The AHCPR Unstable Angina Algorithm in Practice-Reply
Authors: John L. Griffith
Journal: JAMA (1997)

<h3>In Reply.</h3> —We agree with the authors of both letters that the inclusion criteria are critical to both the clinical application and the evaluation of the AHCPR unstable angina guideline. Our data suggest that, among ED patients diagnosed with unstable angina, a very small proportion will be defined as "low risk" by the guideline's criteria. As detailed in our article, we used the Imminent Myocardial Infarction Rotterdam (IMIR) inclusion criteria, which include not only chest pain and the usual chest pain equivalents (chest discomfort, arm pain, neck pain) but also shortness of breath, dizziness, palpitations, and other symptoms suggestive of acute cardiac ischemia. We then restricted our analysis to a broad spectrum of unselected patients with unstable angina, including patients for whom the ED diagnosis of unstable angina was less than certain. The letters also question why our evaluation did not include patients with diagnoses other than unstable angina, such as "rule
Alcohol and Immune Defense
Authors: Fabrizio Spinozzi
Journal: JAMA (1987)

To the Editor.—  We read with interest the article by MacGregor 1 in the Sept 19 issue concerning alcohol abuse and immune defense. This excellent review summarizes clinical and laboratory aspects of various dysfunctions in the cellular, humoral, and polymorphonuclear arms of the immune system in patients with alcoholic liver disease (ALD). However, some aspects of cell-mediated dysfunction in alcoholism need clarification, because several studies on thymus-dependent lymphocytes have given conflicting results.  Study.—  We performed a phenotypic and functional evaluation (by using monoclonal antibodies in a double-color immunofluorescence assay and pokeweed mitogen—driven coculture experiments) of circulating T cells and helper and suppressor T-cell activity on B-cell differentiation in ALD. Our results indicate a normal absolute T-cell number with an expansion of T4 + helper T cells that also coexpress on their surface interleukin 2—receptor complex (as detected by anti-Tac monoclonal antibody). Patients with ALD had 69.9% ±3.1% (0.699 ±0.031) T4 + lymphocytes
J.H.S. Beau and his descriptions of transverse depressions on nails
Authors: KAARE WEISMANN
Journal: British Journal of Dermatology (1977)

Journal Article J.H.S. Beau and his descriptions of transverse depressions on nails Get access KAARE WEISMANN KAARE WEISMANN Department of Dermatology, University of Copenhagen, Rigshospital, DK‐2100 Copenhagen, Denmark Accepted for publication 23 May 1977 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue 5, 1 May 1977, Pages 571–572, https://doi.org/10.1111/j.1365-2133.1977.tb14138.x Published: 01 May 1977
Whither Prometheus' Liver? Greek Myth and the Science of Regeneration
Authors: Carl Power, John E.J. Rasko
Journal: Annals of Internal Medicine (2008)

Stem-cell biologists and those involved in regenerative medicine are fascinated by the story of Prometheus, the Greek god whose immortal liver was feasted on day after day by Zeus' eagle. This myth invariably provokes the question: Did the ancient Greeks know about the liver's amazing capacity for self-repair? The authors address this question by exploring the origins of Greek myth and medicine, adopting a 2-fold strategy. First, the authors consider what opportunities the ancient Greeks had to learn about the liver's structure and function. This involves a discussion of early battlefield surgery, the beginnings of anatomical research, and the ancient art of liver augury. In addition, the authors consider how the Greeks understood Prometheus' immortal liver. Not only do the authors examine the general theme of regeneration in Greek mythology, they survey several scholarly interpretations of Prometheus' torture.
Cardiac Outcomes in Young Adult Survivors of the Arterial Switch Operation for Transposition of the Great Arteries
Authors: Daniel Tobler, William G. Williams, Anusha Jegatheeswaran, Glen S. Van Arsdell, Brian W. McCrindle, Matthias Greutmann, Erwin N. Oechslin, Candice K. Silversides
Journal: Journal of the American College of Cardiology (2010)
Streptococcal Pneumonia: Recent Outbreaks in Military Recruit Populations. A Clinical and Epidemiologic Review.
Authors: James L. Basiliere, Herbert W. Bistrong, William F. Spence
Journal: Annals of Internal Medicine (1967)

s1 May 1967Streptococcal Pneumonia: Recent Outbreaks in Military Recruit Populations. A Clinical and Epidemiologic Review.James L. Basiliere, Herbert W. Bistrong, William F. SpenceJames L. BasiliereSearch for more papers by this author, Herbert W. BistrongSearch for more papers by this author, William F. SpenceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1045_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical and epidemiological features of an epidemic of streptococcal pneumonia (95 cases) are presented. This type of pneumonia is characterized by rather sudden onset of severe symptoms, the most striking of which is chest pain. The clinical course is remarkable in the low prevalence of positive blood cultures and the high frequency of empyema.Therapy consisted of the early vigorous use of antibiotics and the early adequate drainage of the pleural space. Complications other than empyema were few and consisted of pericarditis, pyopneumothorax, toxic psychosis, and lung abscess. Long-term complications included bronchiectasis and pleural thickening. The pleural thickening was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInfectious diseases. Annual review of significant publications. 1 May 1967Volume 66, Issue 5Page: 1045-1045KeywordsAbscessesAntibioticsArmed forcesBloodBronchiectasisClinical epidemiologyIschemiaLungsPneumoniaPopulation statistics Issue Published: 1 May 1967 PDF DownloadLoading ...
Kinetic study of adenosine concentrations and the expression of adenosine deaminase in mononuclear cells during hemodialysis
Authors: Bertrand Dussol, Emmanuel Fenouillet, Phillippe Brunet, Radj Purgus, Nicole Sauze, Louis Carrega, Laurence Mercier, Ibrahim Zouher, Guy Bechis, Yvon Berland, Regis Guieu
Journal: Kidney International (2004)
SUBSTITUTE INFANT-FEEDING.
Authors: HENRY DWIGHT CHAPIN
Journal: JAMA (1900)

The question of the home preparation of an infant's food is one that occasions more or less difficulty to the average practitioner. Very little disturbance of digestion is caused by average breast milk but when it comes to bottle-feeding, trouble often appears, and here the physician has abundant opportunity to show his knowledge of dietetics. There is no end to the number of the so-called "perfect substitute for mother's milk" that are widely advertised, but the mainstay of successful bottle-feeding is good cow's milk. Anything else must be only a temporary substitute. The infants who can not take properly prepared cow's milk are very rare. The trouble often comes from the inability of the physician to properly modify the milk, so as to make it suitable for the case in hand. It is impossible to lay down fixed rules for infant-feeding, as each case must be treated by itself, but
Untreated asymptomatic bacteriuria in girls: II--Effect of phenoxymethylpenicillin and erythromycin given for intercurrent infections.
Authors: S. Hansson, U. Jodal, K. Lincoln, C. Svanborg-Eden
Journal: BMJ (1989)

OBJECTIVE--To investigate the effects of phenoxymethylpenicillin and erythromycin on urinary isolates from patients with untreated asymptomatic bacteriuria. DESIGN--Retrospective study of subgroup of patients from cohort followed up till the end of 1986. SETTING--Outpatient clinic for children with urinary tract infections. PATIENTS--51 Girls aged under 15 with untreated asymptomatic bacteriuria. INTERVENTIONS--Before 1982 intercurrent infections (mostly tonsillitis or otitis) were treated with phenoxymethylpenicillin; after 1982 erythromycin treatment was preferred. END POINTS--Change of bacterial strain in urinary tract and symptomatic recurrences of disease. MEASUREMENTS AND MAIN RESULTS--Bacteria identified by serotype and electrophoretic type and compared before and after antibiotic treatment. Bacteriuria eradicated and replaced by new strains in most patients treated with phenoxymethylpenicillin, leading to symptomatic recurrences in about 15%. Conversely, patients given erythromycin rarely showed change in bacteriuria and none suffered symptomatic recurrence. CONCLUSIONS--In girls with untreated asymptomatic bacteriuria the use of phenoxymethylpenicillin for intercurrent infections may lead to a change of urinary bacteria and leave them at substantial risk of acute pyelonephritis. With erythromycin this risk is small (2/20 courses in this series).
Physiologic Assessment of Jailed Side Branch Lesions Using Fractional Flow Reserve
Authors: Bon-Kwon Koo, Hyun-Jai Kang, Tae-Jin Youn, In-Ho Chae, Dong-Joo Choi, Hyo-Soo Kim, Dae-Won Sohn, Byung-Hee Oh, Myoung-Mook Lee, Young-Bae Park, Yun-Shik Choi, Seung-Jae Tahk
Journal: Journal of the American College of Cardiology (2005)
Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation
Authors: Ashish Jain, Chi A. Ma, Eduardo Lopez-Granados, Gary Means, William Brady, Jordan S. Orange, Shuying Liu, Steven Holland, Jonathan M.J. Derry
Journal: Journal of Clinical Investigation (2004)

Hypomorphic mutations in the zinc finger domain of NF-κB essential modulator (NEMO) cause X-linked hyper-IgM syndrome with ectodermal dysplasia (XHM-ED). Here we report that patient B cells are characterized by an absence of Ig somatic hypermutation (SHM) and defective class switch recombination (CSR) despite normal induction of activation-induced cytidine deaminase (AID) and Iε-Cε transcripts. This indicates that AID expression alone is insufficient to support neutralizing antibody responses. Furthermore, we show that patient B cells stimulated with CD40 ligand are impaired in both p65 and c-Rel activation, and whereas addition of IL-4 can enhance p65 activity, c-Rel activity remains deficient. This suggests that these NF-κB components have different activation requirements and that IL-4 can augment some but not all NEMO-dependent NF-κB signaling. Finally, using microarray analysis of patient B cells we identified downstream effects of impaired NF-κB activation and candidate factors that may be necessary for CSR and SHM in B cells.
Quality Controls in Cellular Immunotherapies: Rapid Assessment of Clinical Grade Dendritic Cells by Gene Expression Profiling
Authors: Luciano Castiello, Marianna Sabatino, Yingdong Zhao, Barbara Tumaini, Jiaqiang Ren, Jin Ping, Ena Wang, Lauren V Wood, Francesco M Marincola, Raj K Puri, David F Stroncek
Journal: Molecular Therapy (2012)

Cell-based immunotherapies are among the most promising approaches for developing effective and targeted immune response. However, their clinical usefulness and the evaluation of their efficacy rely heavily on complex quality control assessment. Therefore, rapid systematic methods are urgently needed for the in-depth characterization of relevant factors affecting newly developed cell product consistency and the identification of reliable markers for quality control. Using dendritic cells (DCs) as a model, we present a strategy to comprehensively characterize manufactured cellular products in order to define factors affecting their variability, quality and function. After generating clinical grade human monocyte-derived mature DCs (mDCs), we tested by gene expression profiling the degrees of product consistency related to the manufacturing process and variability due to intra- and interdonor factors, and how each factor affects single gene variation. Then, by calculating for each gene an index of variation we selected candidate markers for identity testing, and defined a set of genes that may be useful comparability and potency markers. Subsequently, we confirmed the observed gene index of variation in a larger clinical data set. In conclusion, using high-throughput technology we developed a method for the characterization of cellular therapies and the discovery of novel candidate quality assurance markers.
Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer
Authors: Martin D. Forster, Konstantin J. Dedes, Shahneen Sandhu, Sophia Frentzas, Rebecca Kristeleit, Alan Ashworth, Christopher J. Poole, Britta Weigelt, Stan B. Kaye, L. Rhoda Molife
Journal: Nature Reviews Clinical Oncology (2011)
A pressure overload model of congestive heart failure in rats
Authors: S. DESJARDINS, R. W MUELLER, M. J CAUCHY
Journal: Cardiovascular Research (1988)

Approximately 32% of the rats used as animal models showed an elevated heart weight/body weight ratio (0.432[SEM 0.022] g.100 g-1 compared to 0.293[0.009] g.100 g-1 for sham-operated rats), a hydrothorax, pulmonary and liver congestion, and specific histological changes 82-93 weeks after surgically induced aortic constriction. The histological changes were comparable to those observed in hearts of people suffering from long term hypertension. Cardiac failure was also confirmed by depressed contractility as measured by maximum and minimum dP/dt (first derivative of left ventricular pressure), which were 4604(346) and 3627(526) mm Hg.sec-1, respectively, compared with 9165(745) and 5835(268) mm Hg.sec-1 respectively in rats that did not develop left ventricular hypertrophy and failure (CLIP rats). Systolic and left ventricular blood pressures measured under anaesthesia were also decreased: 71.6(5.0) and 88.1(6.3) mm Hg respectively in rats with congestive heart failure, compared with 83.6(2.4) and 109.5(3.6) mm Hg in CLIP rats. Except for a prolonged mean PQ interval associated with a lower heart rate and for a slightly shorter QRS interval in the conscious state, the electrocardiograms of rats with congestive heart failure did not show any major abnormalities specific to ventricular hypertrophy and/or failure. This model could be useful for studying the pathology and adaptative mechanisms in compensated pressure overload induced congestive heart failure as well as in studies comparing pathological changes and means of treatment of congestive heart failure with different aetiologies encountered in the human population.
Liver Enzymes and Liver Biopsy
Authors: Jonathan P. Whitney
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 February 1990Liver Enzymes and Liver BiopsyJonathan P. Whitney, MDJonathan P. Whitney, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-311_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:As an office-based community internist, I believe that the conclusion in the article by Van Ness and Diehl (1) that liver biopsies are helpful in evaluating liver enzyme abnormalities has some flaws. The study's first problem is in how the patients were "referred" to the outpatient gastroenterology clinic at Bethesda Naval Hospital. These patients were apparently already sorted out by primary care physicians and, for one reason or another, were referred to a gastroenterologist for further evaluation. The decisions may have been based on symptoms that the patient presented with or signs that the physician detected during...Reference1. Van NessDiehl MA. Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes? Ann Intern Med. 1989;111:473-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cowley Associates Camp Hill, PA 17011 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1990Volume 112, Issue 4Page: 311-311KeywordsBiopsyEnzymesGastroenterology and hepatologyLiverOutpatient clinicsPrimary care physicians Issue Published: 15 February 1990 PDF DownloadLoading ...
Preliminary identification of a low molecular weight serological mediator in chronic idiopathic urticaria
Authors: C. E. H. GRATTAN, C. G. B. HAMON, M. A. COWAN, R. J. LEEMING
Journal: British Journal of Dermatology (1988)

Sixteen patients with chronic idiopathic urticaria were skin tested with their own serum, 10 with autologous plasma and five with serum that had been heated to 56° C to inactivate complement. Eight showed a weal and flare response to whole serum, four to plasma and five to heat‐treated serum. All serum‐positive patients showed the same response to their own plasma and to heated serum, indicating that the mediator concerned is not generated by clotting and is not dependent on a functioning complement pathway. Three control subjects were negative to autologous serum, plasma and heated serum. Local tachyphylaxis was demonstrated in five serum‐positive patients on reinjection of the same site with autologous serum on 3 consecutive days. This raises the possibility that the serological mediator may be acting by mast cell degranulation or directly on receptors in blood vessels and that repeated injections could induce a change in the number of receptors. Passage of whole autologous serum from four serum‐positive patients through ultrafiltration membranes showed that fractions with a molecular weight of less than 30,000 daltons were still able to produce a positive skin test response, but those less than 1000 daltons were not. All serum fractions from two serum‐negative patients and three normal controls were negative. Whole autologous serum from five serum‐positive patients and two control subjects was separated by column chromatography. On skin testing with pooled fractions, the greatest response was produced by fractions of 10,000–15,000 daltons in the serum‐positive patients, but there was no response in the controls.
Dextropropoxyphene (Distalgesic) overdosage in the West Midlands.
Authors: R M Whittington
Journal: BMJ (1977)

<i>Pseudomonas aeruginosa</i> is the leading pathogen in cystic fibrosis (CF) lungs. Since there is great concern about clonal spread in CF centres, this study examined the <i>P. aeruginosa</i> genotypes of colonised residents of a CF rehabilitation centre. The isolates from the sputum of 76 <i>P. aeruginosa</i>-colonised patients were genotyped by fluorescent amplified fragment length polymorphism on arrival and departure. A total of 71 different <i>P. aeruginosa</i> genotypes were identified from 749 isolates. Forty-nine patients had one genotype, 20 had two genotypes and seven had three. Forty-four patients had one or more genotypes in common with other patients (<i>i.e.</i> cluster types). Thirty-two patients were colonised by a single genotype not shared by any other patient. Thirty-eight of the 44 patients with a cluster type already carried their cluster type strain(s) on arrival. Patient-to-patient transmission could not be excluded for eight patients. For five of these, this infection was transient. None of the environmental <i>P. aeruginosa</i> isolates had a genotype similar to the patients9 genotypes. In summary, most patients were colonised by only one or two <i>P. aeruginosa</i> genotypes and the risk of persistent patient-to-patient transmission was low during the study period (4%). Most patients with a cluster-type strain carried this strain on arrival, indicating that transmission could have happened in the past. No environmental contamination could be established.