tbuckley/cabot-search huggingface dataset:
Army Medical Board.
Authors: John Moore
Journal: JAMA (1890)

War Dep't, Surgeon-General's Office, Washington, D. C., February 8, 1890. <h3>To the Editor:</h3> —Sir: The Surgeon-General directs me to invite your attention to the enclosed notice of the organization of an Army Medical Board, to meet in New York City on May 1, 1890, and to request that you will give it a place in your journal as a matter of news, and to call such attention editorially to it as you may deem proper. Very respectfully, Chas. R. Greenleaf, Major and Surgeon, U. S. Army. NOTICE—AN ARMY MEDICAL BOARD will be in session in New York City, N. Y., from May 1 to 31, 1890, for the examination of candidates for appointmenf in the medical corps of the United States army, to fill existing vacancies. Persons desiring to present themselves for examination by the Board will make application for the necessary invitation to the Secretary of War before April
Application of a novel ultrasound transducer for continuous monitoring treadmill exercise stress echocardiography: Utility in the detection of coronary artery stenosis
Authors: Kenichi Nakashiki, Akira Kisanuki, Yutaka Otsuji, Keiko Yuge, Toshinori Yuasa, Kunitsugu Takasaki, Takeshi Uemura, Bo Yu, Naoko Mizukami, Shuichi Hamasaki, Shinichi Minagoe, Chuwa Tei
Journal: Journal of the American College of Cardiology (2003)
Misdiagnosis of HIV Infection by HIV-1 Plasma Viral Load Testing: A Case Series
Authors: Josiah D. Rich
Journal: Annals of Internal Medicine (1999)

Background: The availability of sensitive assays for plasma HIV viral load and the trend toward earlier and more aggressive treatment of HIV infection has led to the inappropriate use of these assays as primary tools for the diagnosis of acute HIV infection. Objective: To describe limitations in the use of plasma viral load testing for the diagnosis of HIV infection. Design: Case series. Setting: Academic medical centers in Providence, Rhode Island, and Worcester, Massachusetts. Patients: Three persons in whom HIV infection was falsely diagnosed by plasma viral load testing. Measurements: Laboratory measures and clinical outcomes. Results: Two cases of false-positive results obtained by using branched-chain DNA plasma viral load assays and one case of a false-positive result obtained by using reverse transcriptase-polymerase chain reaction plasma viral load assay are reported. All three plasma viral load tests yielded positive results with low values (1254 copies/mL, 1574 copies/mL, and 1300 copies/mL). Infection with HIV was initially diagnosed in all three patients, but each patient subsequently tested negative by HIV-1 enzyme-linked immunosorbent assay and repeated plasma viral load testing. Conclusion: Physicians should exercise caution when using plasma viral load assays to detect primary HIV infection, particularly when the pretest probability of infection is low.
UK doctors' pay award phased again
Authors: L. Beecham
Journal: BMJ (1998)

Doctors in the NHS have been awarded a pay rise above the level of inflation, but the award has been phased for the third year running: they will receive 2% from 1 April and the balance on 1 December.

In the Doctors' and Dentists' Review Body's 1998 report senior and junior hospital doctors and doctors in public and community health have been awarded rises of 4.2% and GPs 5.2% for the year as a whole. When pension increases are taken into account the first group will receive 4.55% and GPs 5.55%. From 1 December a house officer will start on £16 145 ($25 830), a consultant's salary will range from £45 740 to £59 040; and the average GP will earn £49 030 (£47 540 from 1 April). Target payments will add a further £3 500. The phasing means an average increase for doctors this year of 3.9%.

The government has ignored the review body's …
Extended-duration enoxaparin reduced VTE but increased major bleeding in patients with acute medical illness
Authors: Alexander Gallus
Journal: Annals of Internal Medicine (2010)

Source Citation Hull RD, Schellong SM, Tapson VF, et al. Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial. Ann Intern Med. 2010;153:8-18. 20621900
Dermatitis herpetiformis exacerbated by indomethacin
Authors: C.E.M. GRIFFITHS, J.N. LEONARD, LIONEL FRY
Journal: British Journal of Dermatology (1985)

Journal Article Dermatitis herpetiformis exacerbated by indomethacin Get access C.E.M. GRIFFITHS, C.E.M. GRIFFITHS Department of Dermatology, St Mary's Hospital, Praed Street, London W2, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.N. LEONARD, J.N. LEONARD Department of Dermatology, St Mary's Hospital, Praed Street, London W2, U.K. Search for other works by this author on: Oxford Academic Google Scholar LIONEL FRY LIONEL FRY Department of Dermatology, St Mary's Hospital, Praed Street, London W2, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 112, Issue 4, 1 April 1985, Pages 443–445, https://doi.org/10.1111/j.1365-2133.1985.tb02318.x Published: 01 April 1985 Article history Accepted: 14 September 1984 Published: 01 April 1985
Obama overturns ban on federal funding of family planning organisations that promote abortion
Authors: F. Charatan
Journal: BMJ (2009)

The new president of the United States, Barack Obama, has signed an executive order cancelling the restrictions on foreign aid from the US Agency for International Development (USAID) to international family planning programmes that offer abortion or that advocate for abortion rights.

The restriction, first established by President Ronald Reagan in 1984, was dubbed the “global gag rule” by abortion rights groups. It was reversed by Bill Clinton in 1993 and reinstated by George W Bush in 2001. President Bush wrote in a memo to USAID: “It is my …
Incidence of extramedullary disease in patients with multiple myeloma in the era of novel therapy, and the activity of pomalidomide on extramedullary myeloma
Authors: K Detweiler Short, S V Rajkumar, D Larson, F Buadi, S Hayman, A Dispenzieri, M Gertz, S Kumar, J Mikhael, V Roy, R A Kyle, M Q Lacy
Journal: Leukemia (2011)
A CASE OF PRURITUS IN HODGKIN'S DISEASE—LYMPHOGRANULOMATOSIS PRURIGINOSA. *
Authors: F. PARKES WEBER, P. W. DOVE
Journal: British Journal of Dermatology (1918)

Journal Article A CASE OF PRURITUS IN HODGKIN'S DISEASE—LYMPHOGRANULOMATOSIS PRURIGINOSA. Get access F. PARKES WEBER, M.D., F. PARKES WEBER, M.D. Search for other works by this author on: Oxford Academic Google Scholar P. W. DOVE, M.B. (Capt., R.A.M.C). P. W. DOVE, M.B. (Capt., R.A.M.C). Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 30, Issue 1, 1 January 1918, Pages 15–22, https://doi.org/10.1111/j.1365-2133.1918.tb12369.x Published: 01 January 1918
Alveolar Surfactant Protein D Content Modulates Bleomycin-induced Lung Injury
Authors: John Casey, Jennifer Kaplan, Elena N. Atochina-Vasserman, Andrew J. Gow, Helchem Kadire, Yaniv Tomer, James H. Fisher, Samuel Hawgood, Rashmin C. Savani, Michael F. Beers
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Surfactant protein D (SP-D) is a collectin family member with demonstrated immunomodulatory properties in vitro. We hypothesized that SP-D modulates inflammation during noninfectious lung injury in vivo.
Deviation from Developmentally Appropriate Self-Care Autonomy: Association with diabetes outcomes
Authors: Tim Wysocki, Alexandra Taylor, Brenda S Hough, Thomas R Linscheid, Keith O Yeates, Jack A Naglieri
Journal: Diabetes Care (1996)

OBJECTIVE Treatment of IDDM in youth emphasized balancing children's self-care autonomy with their psychological maturity. However, few data exist to guide clinicians or parents, and little is known about correlates of deviations from this ideal. RESEARCH DESIGN AND METHODS In this cross-sectional study, IDDM self-care autonomy of 100 youth was assessed using two well-validated measures. Three measures of psychological maturity (cognitive function, social-cognitive development, and academic achievement) were also collected for each child. Composite indexes of self-care autonomy and of psychological maturity were formed, and the ratio of the self-care autonomy index to the psychological maturity index quantified each child's deviation from developmentally appropriate IDDM self-care autonomy. Based on these scores, participants were categorized as exhibiting constrained (lower tertile), appropriate (middle tertile), or excessive (higher tertile) self-care autonomy. Between-group differences in treatment adherence, diabetes knowledge, glycemic control, and hospitalization rates were explored. RESULTS Analysis of covariance controlling for age revealed that the excessive self-care autonomy group demonstrated less favorable treatment adherence, diabetes knowledge, hospitalization rates, and, marginally, glycemic control. Excessive self-care autonomy increased with age and was less common among intact two-parent families but was unrelated to other demographic factors. CONCLUSIONS The findings indicate caution about encouragement of maximal self-care autonomy among youth with IDDM and suggest that families who succeed in maintaining parental involvement in diabetes management may have better outcomes.
Persistent Mild Hyperphenylalaninemia in the Untreated State
Authors: Harvey L. Levy, Vivian E. Shih, Valerie Karolkewicz, Wilma A. French, Jane R. Carr, Victoria Cass, Joseph L. Kennedy, Robert A. MacCready
Journal: New England Journal of Medicine (1971)

There is substantial evidence that phenylketonuria causes mental subnormality unless specific dietary treatment is begun early in infancy, but much less is known about other forms of hyperphenylalaninemia. We followed nine infants with persistent mild hyperphenylalaninemia from the neonatal period into early childhood. In addition we discovered three siblings and one mother with persistent mild hyperphenylalaninemia as a result of routine study of families in which an affected neonate was found. All 13 subjects remained on a normal diet. The blood phenylalanine concentrations of all infants were no higher than 12 mg per 100 ml (normal less than 2 mg per 100 ml), and these concentrations later remained below 8 mg per 100 ml. The IQ's of the biochemically affected subjects were normal and comparable to those of the unaffected siblings. School grades of the affected children attending school were "good." Dietary therapy appears not to be needed for persistent mild hyperphenylalaninemia.
Biosimilar recombinant human erythropoietin induces the production of neutralizing antibodies
Authors: Kearkiat Praditpornsilpa, Khajohn Tiranathanagul, Pawinee Kupatawintu, Saengsuree Jootar, Tanin Intragumtornchai, Kriang Tungsanga, Tanyarat Teerapornlertratt, Dusit Lumlertkul, Natavudh Townamchai, Paweena Susantitaphong, Pisut Katavetin, Talerngsak Kanjanabuch, Yingyos Avihingsanon, Somchai Eiam-Ong
Journal: Kidney International (2011)
Abstract 2081: FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion
Authors: Jinjun Guo, Yun Zheng, Yunguang Tong, H Philip Koeffler
Journal: Cancer Research (2014)

Abstract Previous studies have shown that both Forkhead Box M1 (FoxM1) and pituitary tumor transforming gene 1 (PTTG1) were associated with cancer development and metastases. This study aims to investigate the relation between FoxM1 and PTTG1 and its role in colorectal cancer cell behavior. The microarray data of colorectal cancer were analyzed to determine the association of FoxM1 and PTTG1 expression. Luciferase reporter assay, ChIP and EMSA were used to identify the regulatory mechanisms between FoxM1 and PTTG1. PTTG1 mRNA and protein levels were examined using real-time PCR and western blot after knocking down or over expressing FoxM1. The roles of FoxM1 and PTTG in tumor metastasis were investigated by cell migration and invasion assays. Gene expression microarray data indicated that FoxM1 and PTTG1 are concordantly up-regulated in colorectal cancer tissues. Over-expression of FoxM1 up-regulated PTTG1 expression and knock-down of FoxM1 did the opposite, indicating that PTTG1 was regulated by FoxM1. Luciferase reporter assay indicated that -391 to +50 bps of PTTG1 promoter are important for FoxM1 to enhance PTTG1 promoter activity. Sequence analysis identified two potential FoxM1 binding sites. EMSA indicated that FoxM1 directly binds to PTTG1 promoter at the -350 to -343 binding motif. This binding was confirmed by chromatin immunoprecipitation in HCT116 and SW620 cells. Boyden chamber assay indicated that FoxM1 and PTTG1 concordantly regulate migration and invasion of HCT116 and SW620 colorectal cancer cells. In summary, our results elucidate that FoxM1 up-regulates PTTG1 transcription through binding to PTTG1 promoter. PTTG1 likely mediates effects of FoxM1 on colorectal cancer cell migration and invasion. Citation Format: Jinjun Guo, Yun Zheng, Yunguang Tong, H Philip Koeffler. FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2081. doi:10.1158/1538-7445.AM2014-2081
Balancing Act: Creating the Right Regulation for Coal Combustion Waste
Authors: John Manuel
Journal: Environmental Health Perspectives (2009)

collapse of a Ten nes see Valley Authority (TVA) ash pond in Kingston, Tennessee, and the arrival of the Obama administra tion the following month, the regulatory ground is shifting in regards to coal com bustion waste (CCW), the millions of tons of waste left over each year from burning coal for electricity.The U.S. Environmental Protection Agency (EPA) is pursuing a host of initiatives that could directly or indirectly affect the disposition of CCW.States, too, are revisiting their regulations.The goal of these initiatives is to ensure public health; the challenge is to do so without compromising a recycling industry that the American Coal Ash Association (ACAA) says keeps about 56 million tons of CCW per year out of the landfilled waste stream. Current Disposition of CCWCCW is created in the process of burning coal to generate steam in electric power plants.The approximately 440 coalfired
Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy
Authors: Ellen M. Lavoie Smith, Herbert Pang, Constance Cirrincione, Stewart Fleishman, Electra D. Paskett, Tim Ahles, Linda R. Bressler, Camilo E. Fadul, Chetaye Knox, Nguyet Le-Lindqwister, Paul B. Gilman, Charles L. Shapiro, for the Alliance for Clinical Trials in Oncology
Journal: JAMA (2013)

<h3>Importance</h3>There are no known effective treatments for painful chemotherapy-induced peripheral neuropathy.<h3>Objective</h3>To determine the effect of duloxetine, 60 mg daily, on average pain severity.<h3>Design, Setting, and Patients</h3>Randomized, double-blind, placebo-controlled crossover trial at 8 National Cancer Institute (NCI)–funded cooperative research networks that enrolled 231 patients who were 25 years or older being treated at community and academic settings between April 2008 and March 2011. Study follow-up was completed July 2012. Stratified by chemotherapeutic drug and comorbid pain risk, patients were randomized to receive either duloxetine followed by placebo or placebo followed by duloxetine. Eligibility required that patients have grade 1 or higher sensory neuropathy according to the NCI Common Terminology Criteria for Adverse Events and at least 4 on a scale of 0 to 10, representing average chemotherapy-induced pain, after paclitaxel, other taxane, or oxaliplatin treatment.<h3>Interventions</h3>The initial treatment consisted of taking 1 capsule daily of either 30 mg of duloxetine or placebo for the first week and 2 capsules of either 30 mg of duloxetine or placebo daily for 4 additional weeks.<h3>Main Outcome Measures</h3>The primary hypothesis was that duloxetine would be more effective than placebo in decreasing chemotherapy-induced peripheral neuropathic pain. Pain severity was assessed using the Brief Pain Inventory-Short Form “average pain” item with 0 representing no pain and 10 representing as bad as can be imagined.<h3>Results</h3>Individuals receiving duloxetine as their initial 5-week treatment reported a mean decrease in average pain of 1.06 (95% CI, 0.72-1.40) vs 0.34 (95% CI, 0.01-0.66) among those who received placebo (P = .003; effect size, 0.513). The observed mean difference in the average pain score between duloxetine and placebo was 0.73 (95% CI, 0.26-1.20). Fifty-nine percent of those initially receiving duloxetine vs 38% of those initially receiving placebo reported decreased pain of any amount.<h3>Conclusion and Relevance</h3>Among patients with painful chemotherapy-induced peripheral neuropathy, the use of duloxetine compared with placebo for 5 weeks resulted in a greater reduction in pain.<h3>Trial Registration</h3>clinicaltrials.gov Identifier: NCT00489411
Regional dynamic behaviour of the canine myocardium following brief ischaemia: wall thickness, wall thickening and blood flow
Authors: H. EGEBLAD, S. HAUNSO, O. AMTORP
Journal: Cardiovascular Research (1982)

Regional myocardial wall characteristics were studied in open-chest anaesthetised dogs. End-diastolic wall thickness and systolic wall thickening were measured by echocardiography and blood flow was quantified by the local 133Xe washout technique during and following coronary artery occlusion of 10 s to 10 min duration. End-diastolic wall thickness exhibited a small temporary increase over baseline value during reperfusion. Maximum value was observed following ischaemic periods of 1 min duration (9.0 +/- 0.5 mm [(Mean +/- 2 SEM) versus a baseline value of 8.2 +/- 0.5 mm (P less than 0.01)]. A post-ischaemic, hyperkinetic and transient systolic wall thickening was most prominent following periods of 2 min of ischaemia (7.1 +/- 0.7 mm; baseline value 4.2 +/- 0.2 mm, P less than 0.01). Extension of ischaemia from 2 min to 10 min provoked no essential change of reactive hyperaemia characteristics (maximum blood flow 257.6 +/- 27.4 cm3 . min-1 . 100 g-1 versus 238.3 +/- 57.0 cm3 . min-1 . 100 g-1, P less than 0.05; duration 62.8 s versus 71.8 s, P less than 0.05). Such extension of the ischaemia, however, made the post-ischaemic, hyperkinetic systolic and transient wall thickening disappear. Considerable asynchrony between variations of blood flow, wall thickness and wall thickening was observed. Determinants with influence on post-ischaemic wall thickness and wall thickening are discussed in relation to the data presented. The resultant of these determinants increasingly favours transient post-ischaemic hyperkinesia following ischaemia of up to 2 min duration, whereas further prolongation of the ischaemia will result in progressive impairment of the myocardial function during reperfusion.
Influence of diets high and low in animal fat on bowel habit, gastrointestinal transit time, fecal microflora, bile acid, and fat excretion.
Authors: J H Cummings, H S Wiggins, D J Jenkins, H Houston, T Jivraj, B S Drasar, M J Hill
Journal: Journal of Clinical Investigation (1978)

Epidemiological observations and animal experiments suggest that large bowel cancer is related to serveral factors. Among them, high dietary intakes of animal fat, the presence in the colon of relatively high levels of bile acids, specific patterns of intestinal microflora, slow transit through the gut, and low stool weights. Under metabolic conditions we have observed the effect on these variables of dietes containing 62 or 152 g/day of fat mainly of animal origin in six healthy young men over 4-wk periods. No change attributable to the diet was observed in the subjects' bowel habit, fecal weight, mean transit time through the gut, or in the excretion of dry matter. Total fecal bile acid excretion was significantly higher on the high fat diet (320 +/- 120 mg/day) than on the low fat diet (139.7) +/- 63 mg/day) t test = 7.78 P less than 0.001 as also was the total fecal fatty acid excretion, 3.1+/-0.71 and 1.14+/-0.35 g/day, respectively t test = 11.4 P less than 0.001). The fecal microflora including the nuclear dehydrogenating clostridia were unaltered by the dietary changes as was fecal beta-glucuronidase activity. Dietary changes which increase animal fat intake clearly influence fecal bile acid excretion in a way that would favor the development of large bowel cancer if current theories prove to be true. Dietary fat however has no effect on overall colonic function so other components of the diet must be responsible for the observed associations of bowel cancer with slow transit and reduced fecal bulk.
Hemodynamic Consequences of Pacing-Induced Changes in Heart Rate in Valvular Aortic Stenosis
Authors: JOSEPH W. LINHART
Journal: Circulation (1972)

Atrial pacing was performed in 10 patients with various degrees of aortic valvular stenosis (AVS) and the hemodynamics were compared to eight normal subjects. Similar maximum heart rates (135 ± 6/min) in each group resulted in no significant complications or symptoms and no changes in cardiac output or transvalvular pressure difference while stroke work (SW) and volume and left ventricular end-diastolic pressure (LVEDP) declined. A postpacing overshoot in LVEDP (control, 14 ± 2; postpacing, 25 ± 3 mm Hg; p = 0.01) which occurred in the cases of AVS probably reflects a decrease in myocardial compliance. Pacing ventricular function curves relating induced changes in SW and LVEDP were generally steeper in patients with AVS than in the normal subjects and were definitely abnormal in three of the former. Pulsus alternans induced in two patients was associated with abnormal myocardial function while the control LVEDP level was not a good indication of the functional response of the myocardium. Atrial pacing appears to be beneficial in the preoperative evaluation of the patient with AVS when exercise stress may be dangerous because of the possibilities of inducing arrhythmias, syncope, and sudden death. It permits precisely controlled evaluation for preoperative and postoperative comparison.
About the CoverIncorporating Art and Creativity Into Medical PracticeCreativity and the Arts in Health Care SettingsWhen Healing Is More Than Simply Clowning AroundHealing Cast in a New Light: The Therapy of Artistic CreationForgive Me, I'm Bleeding
Authors: Ron Willy
Journal: JAMA (1998)

As a medical student, I often hear comments such as "medicine is both art and science." I rarely see the incorporation of the creative arts in daily medical practice. This issue of Pulse presents new perspectives on the value of the arts in medical therapy, healing, and recovery.
Prevention of Head Injuries in Skiing: Mechanisms, Experimental Study, and Prevention
Authors: Bruno Balke
Journal: JAMA (1986)

Fortunately, most falls in downhill skiing do not cause noteworthy trauma. Accidents do occur, however, and keep ski patrol members, physicians, and hospitals in major winter-sport areas busy throughout the ski season. This fact is documented by half of the 66 references cited in this book. Prior to the late 1970s, reports of severe head injuries were rare. But in recent years, as the author clearly shows, the risk of severe trauma to the head has greatly increased. According to a cited statistical survey of skiing accidents in the Tyrolean Alps, covering the period from 1981 to 1983, injuries to the limbs have decreased from 72.4% to 62.8% while injuries to the shoulder have risen from 2.3% to 11.4% and those to the head from 10.6% to 12.2%. The improvements in boot and ski binding design are mentioned as a contributing factor in reducing injuries to the extremities while, on