tbuckley/cabot-search huggingface dataset:
Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue
Authors: David W. Scott, George W. Wright, P. Mickey Williams, Chih-Jian Lih, William Walsh, Elaine S. Jaffe, Andreas Rosenwald, Elias Campo, Wing C. Chan, Joseph M. Connors, Erlend B. Smeland, Anja Mottok, Rita M. Braziel, German Ott, Jan Delabie, Raymond R. Tubbs, James R. Cook, Dennis D. Weisenburger, Timothy C. Greiner, Betty J. Glinsmann-Gibson, Kai Fu, Louis M. Staudt, Randy D. Gascoyne, Lisa M. Rimsza
Journal: Blood (2014)
Mapping the facioscapulohumeral muscular dystrophy gene is complicated by chromosome 4q35 recombination events
Authors: B. Weiffenbach, J. Dubois, D. Storvick, R. Tawil, S.J. Jacobsen, J. Gilbert, C. Wijmenga, J.R. Mendell, S. Winokur, M.R. Altherr, P. Schultz, S. Olandt, R.R. Frants, M. Pericak-Vance, R.C. Griggs
Journal: Nature Genetics (1993)
Smoking During the Eighties: A Waning Flame
Authors: K. Broder, T. Hensley
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Smoking During the Eighties: A Waning Flame Get access Karen Broder, Karen Broder Search for other works by this author on: Oxford Academic PubMed Google Scholar Tim Hensley Tim Hensley Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 3, 7 February 1990, Pages 179–181, https://doi.org/10.1093/jnci/82.3.179 Published: 07 February 1990
Vomiting and Nausea in the First 12 Weeks of Pregnancy
Authors: George M. Iatrakis, Gerasimos G. Sakellaropoulos, Anthony H. Kourkoubas, Stavroula E. Kabounia
Journal: Psychotherapy and Psychosomatics (1988)

Vomiting and nausea occur in many pregnant women, in the first trimester of pregnancy, but the etiology of these symptoms is obscure. A specially constructed questionnaire was administered to 102 pregnant women, in the first 12 weeks of pregnancy, in an effort to see with which factors these disturbing symptoms correlated. Our findings showed that vomiting and nausea correlated with: (1) unsuitable diet with big and rare meals; (2) poor communication with the husband; (3) poor communication with the obstetrician and; (4) stress, doubts and inadequate information about pregnancy, childbirth and health of fetus.
A CASE OF ECTOPIA CORDIS
Authors: W. Rolland
Journal: BMJ (1913)

Although BPIFA1 is one of the most abundant secretory proteins in the upper airways, its9 function remains unclear. We have recently shown a reduction of BPIFA1 in the airways following influenza-A virus infection. In the present study we evaluated the host defence role of BPIFA1 in viral respiratory infection using an <i>in vitro</i> tracheal model. Tracheal epithelial cells isolated from wild-type and <i>bpifa<sup>-/-</sup></i> mice, were seeded onto transwells and differentiated in ALI culture. Differentiated epithelium was infected with influenza-A virus (H3N2). Samples were collected at 2, 24, 48 and 72 hpi (hours post infection). Our data shows that the differentiated epithelial layer mimics the original tracheal epithelium, and abundant BPIFA1 was detected in the apical secretions and cytoplasm of differentiated epithelium. Influenza-A infection initiated inflammatory gene expression, where, IL-6 (2 hpi), TNF-α, IFN-β and IFN-λ2 (24 hpi) were highly upregulated. Influenza-A primarily infected ciliated cells, these cells then lost physical cilia and they down-regulated ciliated gene expression. At low dose (MOI-0.1), BPIFA1 and MUC5B expressing cells were largely uninfected. However, at high dose (MOI-0.5), BPIFA1 +ve cells were also infected and BPIFA1 was down-regulated 6-fold within 48 hpi. At 24 and 48 hpi, viral load was 2.3-fold higher in <i>bpifa<sup>-/-</sup></i> cells with these cells exhibiting increased cell death compared to wild-type cell cultures. Our data suggest that BPIFA1 abrogates influenza-A viral infection and therefore, can be a novel target for antiviral treatment for respiratory tract infections.
Smoking Is Associated With Reduced Serum Paraoxonase Activity and Concentration in Patients With Coronary Artery Disease
Authors: Richard W. James, Ilia Leviev, Alberto Righetti
Journal: Circulation (2000)

Background —Paraoxonase is an HDL-associated enzyme that protects lipoproteins from oxidative modifications. Smoking is a major cardiovascular risk factor that promotes lipid peroxidation. Cigarette smoke has been shown in vitro to inhibit paraoxonase. The present study examined the hypothesis that smoking is associated with modulated serum activities and concentrations of paraoxonase. Methods and Results —Coronary artery disease was assessed with the use of coronary arteriography in participants recruited from a hospital cardiology division. Medical and lifestyle data were obtained, and a fasting blood sample was provided. Three smoking categories were established (never, ex-smokers, and current smokers), and serum paraoxonase variables were compared among them. The activities and concentrations of paraoxonase were significantly lower in current than in never smokers. Ex-smokers had values comparable to those of never smokers. Ex-smokers who had recently stopped (&lt;3 months) had activities and concentrations comparable to those of current smokers; values returned to the levels of never smokers within 2 years of cessation of smoking. Smoking status was an independent determinant of paraoxonase activity and concentration in multivariate analysis. Finally, lower paraoxonase was associated with more severe coronary disease and a reduced capacity to protect LDL from oxidation. Conclusions —Smoking is independently associated with significant decreases in serum paraoxonase activities and concentrations, which normalize within a relatively short time of cessation. Lower serum paraoxonase is linked to more severe coronary artery disease and a lower antioxidant capacity. The data are consistent with the hypothesis that smoking modifies serum paraoxonase such that there is an increased risk of coronary artery disease due to a diminished capacity to protect lipoproteins from oxidative stress.
LONG-TERM THERAPY WITH ROSUVASTATIN INCREASES PROTEIN EXPRESSION OF GROWTH FACTORS AND STEM CELL MARKERS IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH MODERATE HEART FAILURE
Authors: Sharad Rastogi, Michael S. Sabbah, Sudhish Mishra, Kaitlin Dye, Andrew Cavanagh, Hani N. Sabbah
Journal: Journal of the American College of Cardiology (2010)
Diagnosis of Metastatic Melanocarcinoma by Lymphography
Authors: Alex Norman
Journal: JAMA (1963)

THE ACCURACY in detecting tumor metastasis to lymph nodes by lymphography has clearly established limitations. After the initial wave of enthusiasm regarding patterns of lymph node opacification in specific disease entities, investigators in the field have developed more sober outlooks for the diagnostic value of lymphography. Our accumulated knowledge is pointing up less reliance on diagnosis of specific disease except for the group of lymphomas which demonstrate with reasonable frequency the "lacy" or "foamy" pattern of lymph node opacification. The "moth-eaten" pattern of metastatic embolic carcinomatosis to lymph nodes has been an inconsistent finding in our experience, often seen in incomplete opacification from low-volume injections into intralymphatic channels. Fischer et al<sup>1</sup>have likewise revealed radiolucencies in normal contrast medium-filled nodes, so that a filling defect cannot be unequivocally accepted as evidence of metastasis. They showed photographs of lymph nodes in eight individuals of a group of 38 normal males
The deceptive aortic root.
Authors: M Viamote, M Camacho, D R Cahill, M Viamonte, K Mori
Journal: Circulation (1975)

Coronal, horizontal, and sagittal sections through the mid-line are excellent ways of depicting the anatomical position of the aortic root and for studying its topographical relationship to the surrounding vascular structures. Minimal radiographic abnormalities or no abnormalities at all may be present with an enlarged ascending portion of the thoracic aorta. Thus, frontal chest roentgenograms obtained with high kilovoltage, fluoroscopy and left anterior oblique projections should be utilized routinely for the evaluation of the ascending aorta. Calcification of the aortic valve and of the coronary arteries and the study of aortic valve prosthesis also demand a dynamic study and the use of complementary views, such as lateral and both oblique projections.
Abstract 1057: Mutation of EZH2 A677 in human B-cell lymphoma promotes hyper-trimethylation of H3K27
Authors: Michael T. McCabe, Alan P. Graves, Gopinath Ganji, Heidi Ott, Elsie Diaz, Wendy S. Halsey, Yong Jiang, Kimberly N. Smitheman, Melissa B. Pappalardi, Kimberly E. Allen, Stephanie Chen, Anthony Della-Pietra, Edward Dul, Ashley M. Hughes, Sara H. Thrall, Peter J. Tummino, Ryan G. Kruger, Martin Brandt, Benjamin Schwartz, Sharad K. Verma, Caretha L. Creasy
Journal: Cancer Research (2012)

Abstract Trimethylation of histone H3 on lysine 27 (H3K27me3) is a repressive post-translational modification mediated by the histone methyltransferase EZH2. EZH2 is a component of the Polycomb Repressive Complex 2 (PRC2) and its expression and catalytic activity are dysregulated in cancers. While EZH2 may be over-expressed as a result of multiple mechanisms in tumors, only somatic mutation of the EZH2 Y641 residue has thus far been reported to alter its substrate preference and enhance its catalytic efficiency to generate H3K27me3. Herein, we report mutation of the A677 residue of EZH2 to a glycine (A677G) in a lymphoma cell line with aberrantly elevated H3K27me3 levels. Additional EZH2 sequence analysis in 41 primary lymphoma specimens identified another occurrence of this mutation. Biochemical evaluation of recombinant EZH2 complexes revealed that A677G EZH2 possesses catalytic activity with substrate specificity that is novel and distinct from those of wild-type and Y641 mutants. Whereas wild-type EZH2 displayed a preference for substrates with less methylation (i.e. H3K27me0&amp;gt;me1&amp;gt;me2), the Y641 mutants exhibited greatly decreased activity with H3K27me0 and increased activity with H3K27me2. The A677G EZH2, on the other hand, exhibited nearly equal efficiency for all three substrates. A677G EZH2, but not wild-type EZH2, was shown to be capable of significantly increasing global H3K27me3 when transiently expressed in an EZH2 wild-type cancer cell line. Finally, structural modeling suggests that the mutation results in a larger lysine tunnel capable of accommodating the H3K27me2 substrate while retaining the ability to properly orient H3K27me0 and H3K27me1 with the Y641 residue. In addition, functional and biochemical analyses are performed with reversible SAM-competitive EZH2 inhibitors. Therefore, this mutation appears to contribute to the aberrant epigenetic profile observed in certain lymphomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1057. doi:1538-7445.AM2012-1057
Australian government bails out medical indemnity funds
Authors: C. Zinn
Journal: BMJ (2002)

The medical profession has had mixed reactions to the federal government's reform package to safeguard medical indemnity insurance, which it has unveiled after months of negotiation.

The rescue strategy, which will cost taxpayers $A45m (£16m; $25m; €26m) a year, will see taxpayers subsidise the insurance premiums for doctors in specialties that carry a high risk, such as obstetricians, neurosurgeons, and general practitioners who perform minor surgery.

The government will also pay half the cost of medical negligence awards of more than $A2m and will extend its guarantee for the medical insurer United Medical Protection for another 12 months to December …
Multiple Effects of Silymarin on the Hepatitis C Virus Lifecycle
Authors: Jessica Wagoner, Amina Negash, Olivia J. Kane, Laura E. Martinez, Yaakov Nahmias, Nigel Bourne, David M. Owen, Joe Grove, Claire Brimacombe, Jane A. McKeating, Eve-Isabelle Pécheur, Tyler N. Graf, Nicholas H. Oberlies, Volker Lohmann, Feng Cao, John E. Tavis, Stephen J. Polyak
Journal: Hepatology (2010)

Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo. In the current study, we further characterized silymarin's antiviral actions. Silymarin had antiviral effects against hepatitis C virus cell culture (HCVcc) infection that included inhibition of virus entry, RNA and protein expression, and infectious virus production. Silymarin did not block HCVcc binding to cells but inhibited the entry of several viral pseudoparticles (pp), and fusion of HCVpp with liposomes. Silymarin but not silibinin inhibited genotype 2a NS5B RNA-dependent RNA polymerase (RdRp) activity at concentrations 5 to 10 times higher than required for anti-HCVcc effects. Furthermore, silymarin had inefficient activity on the genotype 1b BK and four 1b RDRPs derived from HCV-infected patients. Moreover, silymarin did not inhibit HCV replication in five independent genotype 1a, 1b, and 2a replicon cell lines that did not produce infectious virus. Silymarin inhibited microsomal triglyceride transfer protein activity, apolipoprotein B secretion, and infectious virion production into culture supernatants. Silymarin also blocked cell-to-cell spread of virus. Although inhibition of in vitro NS5B polymerase activity is demonstrable, the mechanisms of silymarin's antiviral action appear to include blocking of virus entry and transmission, possibly by targeting the host cell.
Multiple lesions of pyoderma gangrenosum in association with hyper-reactive malarial splenomegaly
Authors: D. Moreno-Ramirez, A. Herrera-Saval, J.J. Rios-Martin, I. Blasco-Esquivias, F. Camacho
Journal: British Journal of Dermatology (2004)

Journal Article Multiple lesions of pyoderma gangrenosum in association with hyper‐reactive malarial splenomegaly Get access D. Moreno‐Ramírez, D. Moreno‐Ramírez Departments of Dermatology, Pathology and Medicine, University Hospital Virgen Macarena, Seville, Spain D.Moreno‐Ramírez. E‐mail: morenez@yahoo.es Search for other works by this author on: Oxford Academic Google Scholar A. Herrera‐Saval, A. Herrera‐Saval Departments of Dermatology, Pathology and Medicine, University Hospital Virgen Macarena, Seville, Spain Search for other works by this author on: Oxford Academic Google Scholar J.J. Ríos‐Martín, J.J. Ríos‐Martín Departments of Dermatology, Pathology and Medicine, University Hospital Virgen Macarena, Seville, Spain Search for other works by this author on: Oxford Academic Google Scholar I. Blasco‐Esquivias, I. Blasco‐Esquivias Departments of Dermatology, Pathology and Medicine, University Hospital Virgen Macarena, Seville, Spain Search for other works by this author on: Oxford Academic Google Scholar F. Camacho F. Camacho Departments of Dermatology, Pathology and Medicine, University Hospital Virgen Macarena, Seville, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 3, 1 March 2004, Pages 605–607, https://doi.org/10.1046/j.1365-2133.2004.05824.x Published: 01 March 2004
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
Authors: Peter A. Steck, Mark A. Pershouse, Samar A. Jasser, W.K. Alfred Yung, Huai Lin, Azra H. Ligon, Lauren A. Langford, Michelle L. Baumgard, Thomas Hattier, Thaylon Davis, Cheryl Frye, Rong Hu, Bradley Swedlund, David H.R. Teng, Sean V. Tavtigian
Journal: Nature Genetics (1997)
Possible targeting of G protein coupled receptors to manipulate inflammation in vivo using synthetic and natural ligands
Authors: J F Kinsel
Journal: Annals of the Rheumatic Diseases (2003)

Cyclic AMP elevating Gs protein coupled receptors were considered for a long time to be immunosuppressive. One of these receptors, adenosine A<sub>2A</sub> receptor, was implicated in a physiological mechanism that down regulates inflammation and protects tissues from excessive immune mediated damage. Targeting of these receptors by selective agonists may lead to better protocols of anti-inflammatory treatments. At the same time inhibiting the Gs protein coupled mediated signalling with antagonists could be explored in studies of approaches to enhance inflammation and tissue damage. Enhancement of targeted tissue damage is highly desirable when it is cancerous tissue, while enhancement of inflammatory events might be desirable in the development of new vaccine adjuvants.
Self-Reported Autoimmune Disease by Sex in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
Authors: Elizabeth Buschur, Aruna V. Sarma, Massimo Pietropaolo, Rodney L. Dunn, Barbara H. Braffett, Patricia A. Cleary, Catherine Cowie, Mary E. Larkin, Hunter Wessells, David M. Nathan, Catherine Kim
Journal: Diabetes Care (2014)

People with type 1 diabetes have an increased risk for autoimmune thyroid disease, which is more common in women than in men according to at least one (1) but not all (2) studies. Exposures unique to women, such as pregnancy, exogenous estrogen, and menopause, have been linked to other autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus (3). However, studies examining such exposures in women with type 1 diabetes are unavailable.

Because the incidence of type 1 diabetes is increasing worldwide, it is important to determine the factors associated with comorbid conditions (4). We analyzed participants ( n = 1,324) in the Diabetes Control and Complications Trial (DCCT), a randomized trial of intensive insulin therapy, and its follow-up, Epidemiology of Diabetes Interventions and Complications (EDIC). With the use of Cox regression models, we estimated hypothyroid risk associated with sex, age, DCCT treatment group, diabetes duration, microvascular complications, and hemoglobin A1c (HbA1c). Among women, we further examined parity, menopause, and estrogen use. We also report the cumulative …
PHYSICAL CAUSES OF HEART DISEASE, AND TREATMENT.Read before the Section of Internal Medicine, at the Tenth International Medical Congress, Berlin, 1890.
Authors: EPHRAIM CUTTER
Journal: JAMA (1891)

Corresponding Member Belgian and Italian Microscopical S cieties; Member of American Society of Microscopists; President American Branch Society of Science, Letters and Art, of London. Things that increase the work of the heart are physical causes of its diseases, as follows: <i>A. Hæmic</i>. That is from the blood and its vessels, including the heart itself.<i>B. Trophopathic</i>—from the food, to-wit: gases, fermentation, fatty and fibrous degeneration, catarrhs.<i>C. Gynecologic</i>—from reflex uterine irritation.<i>D. Motto al</i>—as running, lifting heavy weights and climbing ascents.<i>E. Emotional</i>—as, passions.<i>F. Postural. G. Heredity. H. Inflammatory</i>, etc., to name no more. The limits allow only a brief discussion of the causes A, B, C and F. Perhaps it is best, as D, E, G and H are well understood. We start with the idea that in health the heart can do its great work. We emphasize great, for we think few realize its greatness. It
Physiologic determinants of the electrocardiographic diagnosis of left ventricular hypertrophy.
Authors: E M Antman, L H Green, W Grossman
Journal: Circulation (1979)

The relative importance of left ventricular (LV) geometry, wall thickness, and mass on the inscription of left ventricular hypertrophy (LVH) on the ECG was examined in 93 patients; 36 had no LVH on the ECG, 10 had borderline voltage for LVH, and 47 had LVH on the ECG. LV cineangiograms in the right anterior oblique projection were analyzed for LV end-diastolic volume, free wall thickness (h), semiminor radius (R), LV mass index (LVMI), and the geometric relations described by h/R, mass/volume, and h . R. Although mean LVMI was greater in patients whose ECG voltage was either borderline or diagnostic of LVH, increased LVMI also occurred without LVH on the ECG. None of the variables (h, R, h/R or mass/volume) reliably indicated when LVH would be inscribed on the ECG. The product of h . R, however, defined three electrocardiographic groups; all patients with LVH on their ECG had h . R greater than 2.6 cm2. Wall thickening sufficient to result in an increased LV mass did not result in LVH on the ECG unless sufficient concurrent chamber dilatation was present. Thus, a critical geometric relationship resulting from the interplay of wall thickness and chamber dilatation is necessary for LVH to appear on the ECG. This finding is consistent with the solid-angle theory of electrocardiography as it relates to ventricular hypertrophy.
ASPERGILLUS INFECTION OF THE HAND
Authors: John T. Myers
Journal: JAMA (1930)

Organisms commonly considered nonpathogenic may at times show definite disease-producing properties. However, they are rare experiences. Even<i>Bacillus subtilis</i>, a ubiquitous saprophyte, has been reported as the cause of panophthalmitis by Silberschmidt and others.<sup>1</sup>Charrin and Nittis<sup>2</sup>showed that<i>B. subtilis</i>acquired considerable pathogenic power by repeated transfers on blood agar. It has long been known that saprophytic molds may manifest pathogenic properties. Certain mucors, penicillium and aspergillus have been frequently reported. Harmer and Jackes<sup>3</sup>reported<i>Aspergillus fumugatus</i>in pus from a maxillary sinus; MacFarlan,<sup>4</sup>aspergillus niger from a tongue lesion; and Lynch,<sup>5</sup>following bites of the red bug (leptus), or chigger. Panayotatou<sup>6</sup>isolated a variety of penicillium which is usually harmless from a tongue lesion; the organism was definitely pathogenic for mice but not for rabbits. As might be anticipated, many cases of fungus infection have been reported in which the organism was
Contributions of the Measles Virus Nucleocapsid Gene and the SQSTM1/p62P392L Mutation to Paget's Disease
Authors: Noriyoshi Kurihara, Yuko Hiruma, Kei Yamana, Laëtitia Michou, Côme Rousseau, Jean Morissette, Deborah L. Galson, Jumpei Teramachi, Hua Zhou, David W. Dempster, Jolene J. Windle, Jacques P. Brown, G. David Roodman
Journal: Cell Metabolism (2011)
MICROBIC VIRULENCE AND HOST SUSCEPTIBILITY IN PARATYPHOID-ENTERITIDIS INFECTION OF WHITE MICE. II
Authors: Leslie T. Webster
Journal: The Journal of Experimental Medicine (1923)

1. Six strains of paratyphoid-enteritidis bacilli, isolated from man and animals, differed markedly in virulence for mice. 2. The inherent virulence of each strain for mice was not affected by repeated intraperitoneal and per os mouse passage. 3. Individual differences in the susceptibility of the mice to each strain and to graded doses of mercury bichloride were demonstrable. Such variations appear to be of a non-specific nature.