Dimethyl Sulfoxide and Extravasation of Anthracycline Agents
Authors: H. JEFFREY LAWRENCE
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 June 1983Dimethyl Sulfoxide and Extravasation of Anthracycline AgentsH. JEFFREY LAWRENCE, M.D., SCOTT H. GOODNIGHT JR., M.D.H. JEFFREY LAWRENCE, M.D.Search for more papers by this author, SCOTT H. GOODNIGHT JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1025_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Extravasation of anthracycline chemotherapeutic agents into subcutaneous tissues is a feared complication of cancer treatment. Immediate maneuvers to prevent or reduce tissue necrosis include application of ice packs; local instillation of sodium bicarbonate, corticosteroids, or both together; and early surgical debridement (1, 2). Unfortunately, tissue necrosis often occurs despite these efforts. Desai and Teres (3) recently reported from a controlled study that topical dimethyl sulfoxide prevented tissue necrosis after intradermal injections of doxorubicin in Spraque-Dawley rats. This experimental observation has not been confirmed by others (DORR RT. Unpublished observation).We recently observed a possible beneficial effect of...References1. DORRFRITZ RW. Cancer Chemotherapy Handbook. New York: Elsevier; 1980:109-34. Google Scholar2. ZWEIGKABAKOW JB. An apparently effective countermeasure for doxorubicin extravasation [Letter]. JAMA. 1978;239:2116. CrossrefMedlineGoogle Scholar3. DESAITERES MD. Prevention of doxorubicin-induced skin ulcers in the rat and pig with dimethyl sulfoxide (DMSO). Cancer Treat Rep. 1982;66:1371-4. MedlineGoogle Scholar4. MARTINHAUTHAL DH. Dimethyl Sulphoxide. New York: Halsted Press; 1975:467-74. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Oregon Health Sciences University School of Medicine Portland, OR 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDexrazoxane: a management option for anthracycline extravasationsDimethyl Sulfoxide and Sodium Bicarbonate in the Treatment of Refractory Cancer PainDaunorubicinAnthracycline Extravasation: A Comprehensive Review of Experimental and Clinical TreatmentsManagement of Anthracycline Extravasation InjuriesDérivés organiques soufrésDaunorubicinDaunorubicinPrevention and Management of Antineoplastic Extravasation InjuryReview : Utilization of dimethyl sulfoxide for treating anthracycline extravasationTopical dimethylsulfoxide may prevent tissue damage from anthracycline extravasationFree radical formation by antitumor quinonesThe optimal management of cytotoxic‐drug extravasation: solving the burning questionThe management of cytotoxic‐drug extravasation: guide‐lines drawn up by a working party for the Clinical Oncological Society of AustraliaPrevention of cytotoxic drug induced skin ulcers with dimethyl sulfoxide (DMSO) and α-tocopheroleDaunorubicin (z.B. Daunoblastin®) 1 June 1983Volume 98, Issue 6Page: 1025-1025KeywordsBicarbonatesCancer treatmentChemotherapeutic agentsIntradermal injectionsNecrosisSodium Issue Published: 1 June 1983 PDF downloadLoading ...