tbuckley/cabot-search huggingface dataset:
Leadership in American Medicine
Authors: John Gordon Freymann
Journal: New England Journal of Medicine (1964)

There is today no subject. . . that deserves and will require more careful, exhaustive, dispassionate and unprejudiced study than social insurance, or that will, whatever the final conclusions, demand greater tact, diplomacy and good judgment in practical handling. It is, therefore, of the utmost importance that physicians both as individuals and organizations abandon the attitude of unreasoning opposition which has characterized many of our professional discussions on this question and make an honest effort to study the problems involved and to arrive at conclusions which can be justified. . . By the end of another year the question may . . .
LYMPHOID CELLULAR RESPONSES IN THE BLOOD AFTER IMMUNIZATION IN MAN
Authors: D. Crowther, G. Hamilton Fairley, R.L. Sewell
Journal: The Journal of Experimental Medicine (1969)

A combined morphological and metabolic study has been made of the lymphoid cells in the blood during the immune response in man. Similar changes were observed in both primary and secondary responses to a number of different microbial antigens. The cellular response involved an increase in numbers of three types of cell; hyperbasophilic medium lymphocytes, plasma cells, and large lymphoid cells. The large lymphoid cells were about 20 micro in diameter with large nuclei, prominent nucleoli, and an intensely basophilic cytoplasm with numerous polyribosomes. About 30% of these cells were in the DNA synthetic phase of cell growth. Electron microscopy has shown that many of the basophilic medium-sized cells have sufficient well-organized endoplasmic reticulum to be included in the plasma cell series. The hyperbasophilic cells labeled more heavily with tritiated uridine and tritiated leucine than the normal small and medium lymphocytes from the peripheral blood of patients not under antigenic stimulation. The evidence in this paper supports the argument that the atypical mononuclear cells first described by Türk and others in the blood of patients with infections are immunoblasts, plasma cells, and other reactive lymphoid cells representing a circulating population of lymphoid cells derived from lymphoid tissue responding to antigenic stimulation. The presence of such cells may be a valuable indication that an immunological reaction is in progress when direct proof is lacking.
ON MEDICAL EVIDENCE
Authors: J. G. Davey
Journal: BMJ (1856)

range of buildings, ued as an rmo. a aitary point of view, this high wall and circular building ae de.trimental; but the building itself being very high, and aU the wards up stairs at a considerable elevation, the ill effects of this arrangement are not so objectionable.It is, in fact, an imposing old building, and in summer makes an excellent hospital.The supply of water is pretty good, but the quality of it is not what it should be.ation and Diet.These are good.The former are duly inspected by the officers; the men mess together; have three meals; and recruits soon become stout and ro- bust.The hospital diets, under the control of the medical officer, are good, and varied as required.The meat is of good quality, and, for hospital diets, a little higher price is allowed to be given for it.The effect of the men's messing together is very beneficial, and teaches them orderly habits.Duty and Eqnyloyment.The duty is moderate and very regular, and by no means so severe as to prove prejudicial to the health of the men.Inter,na Economy.No canteen exists; hence intem- perance is checked, but by no means prevented, as one-half the regiment is billeted out, and consequently, in a large seaport town like Hull, the men are much exposed to temp- tation.Crimes and Punishment.Crimes and punishment, for the number of men, are below the average; and, on the whole, their conduct has been exemplary, and the men are popular with the residents.Desertions were not frequent, and generally amongst the recruits who were attested, but did not join when the regiment was embodied.Three or four were branded with letter D. The propriety of this may be fairly questioned in a militia regiment.Exercise, etc.The barrack-yard and ramparts afford space for exercise and amusement.Cricket, football, quoits, racket, and other games, are encouraged, in which the officers join (the "doctor " not the least active of the on 20 August
HERPES ZOSTER FOLLOWING TRIVIAL INJURY: WITH NOTES OF A CASE
Authors: JOHN KINNEAR
Journal: British Journal of Dermatology (1952)

Journal Article HERPES ZOSTER FOLLOWING TRIVIAL INJURY: WITH NOTES OF A CASE Get access JOHN KINNEAR, O. B. E., M. D., M. R. C. P. Ed JOHN KINNEAR, O. B. E., M. D., M. R. C. P. Ed Department of Dermatology of the University of St. Andrews Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 64, Issue 9, 1 September 1952, Pages 324–328, https://doi.org/10.1111/j.1365-2133.1952.tb15814.x Published: 01 September 1952
Echocardiographic measurement of right ventricular wall thickness. A new application of subxiphoid echocardiography.
Authors: H Matsukubo, T Matsuura, N Endo, J Asayama, T Watanabe
Journal: Circulation (1977)

The feasibility of subxiphoid echocardiography to measure the thickness of the right ventricular wall (RVWT) was investigated. In 87 (90.6%) of the 96 patients studied, adequate visualization of the echoes from the right ventricular wall was obtained using the subxiphoid technique. RVWT averaged 0.34 +/- 0.08 cm (mean +/- 1 SD), ranging from 0.2 to 0.5 cm in 25 normal individuals. This was not significantly different from the values in the left ventricular overload group (0.36 +/- 0.10 cm). However, the RVWT was increased significantly (P less than 0.001) in the combined group (0.62 0.18 cm), the right ventricular (RV) pressure overload group (0.60 +/- 0.13 cm) and the RV volume overload group (0.53 +/- 0.11 cm). Thirty-two patients underwent diagnosis right heart catheterization which revealed a good correlation between the RVWT measured echocardiographically and the right ventricular peak systolic pressure (r = 0.84). Subxiphoid echocardiography was considered to be useful in diagnosing right ventricular hypertrophy in adults.
A REGISTRY OF BIODEGRADABLE VERSUS DURABLE POLYMER PACLITAXEL - ELUTING STENTS.
Authors: Peter P. Buszman, Bartlomiej Orlik, Michal Kozlowski, Marek Krol, Marek Kondys, Janusz Drzewiecki, Michal Tendera, R. Stefan Kiesz, Pawel E. Buszman
Journal: Journal of the American College of Cardiology (2010)
Fulminant hepatitis related to transmission of hepatitis B variants with precore mutations between spouses
Authors: Shigeru Yotsumoto, Mineo Kojima, Isao Shoji, Kayoko Yamamoto, Hiroaki Okamoto, Shunji Mishiro
Journal: Hepatology (1992)

A precore defective variant of hepatitis B virus has been indicated to cause fulminant hepatitis in various instances such as intrahospital outbreaks or mother-to-child transmission of hepatitis B virus. To learn whether similar variants are involved in interspouse transmission, we analyzed three cases of fulminant hepatitis B that developed in formerly healthy subjects whose only exposure to hepatitis B virus was contact with their longtime spouses, who were carriers of HBV and positive for antibody to HBe. The DNA clones for precore and S genes were propagated from patients and spouses and sequenced. Because of the conservation of S-gene sequences and the identity of subtypes between patient and spouse, it was suggested that patients were infected with hepatitis B virus from their spouses, not from other sources. A TGG-to-TAG mutation at the 28th codon of the precore gene of hepatitis B virus was commonly observed in all DNA clones from patients with fulminant hepatitis and from their spouses. A 29th-codon GGC-to-GAC mutation was additionally evident in DNAs from one patient-and-spouse couple. A significant rise in the circulating hepatitis B virus concentration was transiently observed in the index spouse of this case just before development of fulminant hepatitis in her husband. The increase in circulating HBV DNA was associated with a rise in abundancy of variants with mutations at both the 28th and 29th codons, compared with variants with only a 28th-codon mutation. The double mutation in hepatitis B virus DNA may either help the virus escape immune surveillance or replicate at a higher rate than before.
Bone Scintigraphy in Childhood Idiopathic Hypertrophic Osteoarthropathy
Authors: JOHN R. STY, KUMUDCHANDRA SHETH, ROBERT J. STARSHAK
Journal: Clinical Nuclear Medicine (1982)

STY, JOHN R. M.D.; SHETH, KUMUDCHANDRA M.B., M.R.C.P.(C), D.C.H.; STARSHAK, ROBERT J. M.D. Author Information
Accelerated Atherosclerosis and Calcification in Vein Grafts
Authors: J.H.P. Lardenoye, M.R. de Vries, C.W.G.M. Löwik, Q. Xu, C.R. Dhore, J.P.M. Cleutjens, V.W.M. van Hinsbergh, J.H. van Bockel, P.H.A. Quax
Journal: Circulation Research (2002)

Vein grafts fail due to development of intimal hyperplasia and accelerated atherosclerosis. Many murine genetic models in which genes are overexpressed, deleted, or mutated have been introduced recently. Therefore, mouse models are very well suited to dissect the relative contribution of different genes in the development of accelerated atherosclerosis. In the present study, we evaluated whether accelerated atherosclerosis in human vein grafts could be mimicked in hypercholesterolemic APOE*3 Leiden transgenic mice. Venous bypass grafting was performed in the carotid artery in APOE*3 Leiden mice fed either a standard chow diet or a high cholesterol-rich diet for 4 weeks. At several time points (0 hour to 28 days), mice were euthanized and the morphology of the vein grafts was analyzed. In normocholesterolemic mice, vein graft thickening up to 10-fold original thickness, predominantly consisting of alpha-smooth muscle cell actin-positive cells, was observed after 28 days. In hypercholesterolemic mice, accelerated atherosclerosis with accumulation of lipid-loaded foam cells was observed within 7 days after surgery. This accelerated atherosclerosis progressed in time and resulted in significant increase in vein graft thickening up to 50 times original thickness with foam cell-rich lesions and calcification within 28 days after surgery. The atherosclerotic lesions observed in these murine grafts show high morphological resemblance with the atherosclerotic lesions observed in human vein grafts. This accelerated, diet-dependent induction of atherosclerotic-like lesions in murine vein grafts provides a valuable tool in evaluating the mechanisms of accelerated atherosclerosis and therapeutic interventions of vein graft disease.
Bevacizumab in Glioblastoma — Still Much to Learn
Authors: Howard A Fine
Journal: New England Journal of Medicine (2014)

Glioblastoma, which remains one of the most lethal tumors, is associated with a median survival of only approximately 15 months, despite aggressive combination therapy. Interest in therapeutic targeting of the florid angiogenesis characteristic of glioblastoma led to several phase 2 trials of bevacizumab, a humanized monoclonal antibody targeted against vascular endothelial growth factor (VEGF), in patients with recurrent glioblastoma.13 These early trials showed dramatic and unprecedented responses on magnetic resonance imaging (MRI) (and, occasionally, clinical responses) among patients with a recurrent tumor for which no effective treatment existed, thereby leading to approval of bevacizumab by the Food and Drug . . .
Systemic-Pulmonary Arterial Shunts in the First Year of Life
Authors: NESTOR J. TRUCCONE, FREDERICK O. BOWMAN, JAMES R. MALM, WELTON M. GERSONY
Journal: Circulation (1974)

Results of systemic to pulmonary arterial shunts during the first year of life are reported in 86 infants under one year of age. Survival rates were highest in older patients and among infants whose basic cardiac defects were considered to be eventually amenable to surgical repair. Persistent hypoxia accounted for the majority of deaths. Congestive heart failure secondary to too large anastomoses occurred in 32.5% of Waterston shunts, but could be successfully managed medically in the majority of patients. Surgical revision of the shunt was accomplished successfully in two infants with subsequent alleviation of symptoms. Congestive heart failure occurred in only one of 26 patients after a Blalock shunt. Ten of the twelve patients in this series survived open-heart repair for cardiac lesions. It will eventually be necessary to compare these data with the results of single stage corrective surgery in the infant group.
Prothrombin Pattern over the 24 hours in Patients receiving Oral Anticoagulants
Authors: H. L. Matthews, M. J. Meynell, C. G. Parsons, E. G. Warburton, J. A. H. Waterhouse
Journal: BMJ (1955)

Much is known about daily prothrombin concentration in patients receiving oral anticoagulants, but we can find no published observations on prothrombin levels at shorter intervals.The purpose of this investigation was to determine the variation of prothrombin concentrations throughout the 24 hours.Methods Nineteen patients were studied (17 males and 2 females); 9 had myocardial infarcts, 4 coronary insufficiency, 3 venous thromboses in the leg, and 3 pulmonary embolisms.Ten patients received phenindione (" dindevan") and 9 ethyl biscoumacetate (" tromexan ").All prothrombin estima- tions were made by one of us (E.G. W.), using Quick's one- stage method.The anticoagulant was given as a single dose at 6 p.m., and blood specimens were taken two-hourly from 6 p.m. until 6 p.m. the following day.The interval between the start of treatment and the 24-hour test period varied from patient to patient.Results The two-hourly prothrombin concentrations are expressed as a percentage of normal in Tables I andIU.The mean
Extrapyramidal side effects of lithium treatment.
Authors: B Johnels, L Wallin, J Walinder
Journal: BMJ (1976)

Pyloric stenosis and sustained-release iron tablets SIR,-The case reported below gives an interesting and salutary warning about the possible effects of giving long-acting iron tablets to patients with a history of peptic ulceration or long-standing dyspepsia.The patient, an arthritic spinster of 74 who was known to live on a diet of cake and Maltesers, was started on treatment with Ferrogradumet C for a
Depletion of reactive advanced glycation endproducts from diabetic uremic sera using a lysozyme-linked matrix.
Authors: T Mitsuhashi, Y M Li, S Fishbane, H Vlassara
Journal: Journal of Clinical Investigation (1997)

Diabetic uremic sera contain excessive amounts of reactive advanced glycation endproducts (AGEs), which accelerate the vasculopathy of diabetes and end-stage renal disease. To capture in vivo-derived toxic AGEs, high affinity AGE-binding protein lysozyme (LZ) was linked to a Sepharose 4B matrix. Initial studies showed that > 80% of 125I-AGE-BSA was retained by the LZ matrix, compared with < 10% retained by a control matrix. More than 60% of AGE-lysine was captured by the LZ matrix, and the LZ-bound fraction retained immunoreactivity and cross-linking activity, but had little intrinsic fluorescence (370/440 nm). After passage through the LZ matrix, AGE levels in diabetic sera (0.37+/-0.04 U/mg) were significantly reduced to a level (0.09+/-0.01 U/mg; n = 10; P < 0. 0001) comparable with the level of normal human serum, whereas total protein absorption was < 3%. The AGE-enriched serum fraction exhibited cross-linking activity, which was completely prevented by aminoguanidine. Among numerous LZ-bound proteins in diabetic uremic sera, three major proteins "susceptible" to AGE modification were identified: the immunoglobulin G light chain, apolipoprotein J (clusterin/SP-40,40), and the complement 3b beta chain. These findings indicate that the LZ-linked AGE affinity column may serve as an efficient method for the depletion of toxic AGEs from sera, including specific AGE-modified proteins that may be linked to altered immunity, lipoprotein metabolism, and accelerated vasculopathy in renal failure patients with or without diabetes.
International Aspects of US Government Tobacco Bills
Authors: Judith Mackay
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of B cells malignancies with anti-CD19 CAR+, TCR-, CD52- allogeneic T cells
Authors: Cécile Schiffer Mannioui, Laëtitia Lemaire, Laurent Poirot, Agnes Gouble, Sylvain Arnould, Roman Galetto, Julianne Smith, Andrew Scharenberg
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Encouraging data have emerged from adoptive T-cell therapies in advanced forms of cancer. Anti-tumor immunity is found in tumor infiltrating lymphocytes as well as engineered T cells where exogenous expression of a chimeric antigen receptor (CAR) confers cancer recognition on the
Why the Citation?
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1974)

IF plans had materialized, an invited scientific editorial would have appeared in this spot. At the last moment, however, the author withdrew his excellent contribution because he could not accept the Journal's format for citing references. According to this system, the number of authors' names for any item listed under "References" is limited to three, those remaining being subsumed under "et al." This practice, modeled after and sanctioned by the National Library of Medicine's Index Medicus, is observed by at least 30 other American biomedical publications. It finds its immediate cause in the multiple authorship of so many of . . .
Alpha gliadin antibody levels: a serological test for coeliac disease.
Authors: C O'Farrelly, J Kelly, W Hekkens, B Bradley, A Thompson, C Feighery, D G Weir
Journal: BMJ (1983)

The diagnostic value in coeliac disease of circulating antibodies to casein, crude gliadin, and alpha gliadin was assessed using an adaption of the enzyme linked immunosorbent assay system. alpha Gliadin was the only antigen which consistently separated 26 patients with untreated coeliac disease from 26 normal controls and 13 patients with chronic inflammatory bowel disease. The mean assay index for the 26 patients was 3.1 (SD 1.2) compared with 1.05 (0.5) for the normal controls and 1.1 (0.6) for patients with chronic inflammatory bowel disease. The alpha gliadin antibody levels of six patients with coeliac disease who had maintained a gluten free diet for at least two years were not significantly higher than normal (1.0 (0.4)). The validity of the test was determined in 90 consecutive patients who were being investigated for the presence of coeliac disease. Levels of alpha gliadin antibody were raised in 36 out of 44 patients found to have histologically proved coeliac disease and in six out of 46 subjects whose jejunal mucosa was normal. Serial alpha gliadin concentrations were measured in 12 patients with coeliac disease who had repeat jejunal biopsies performed six months after starting a gluten free diet. The levels of antibody fell in seven of the eight patients whose jejunal mucosa improved on maintaining the diet. They remained raised in four patients who did not adhere to the diet and whose mucosa did not improve. Although a test measuring alpha gliadin antibodies is unlikely to replace jejunal biopsy in the diagnosis of coeliac disease it may be useful in screening for the disease among outpatients.
The Only EKG Book You'll Ever Need
Authors: L. Thomas Sheffield
Journal: JAMA (1989)

This is an attractive textbook with a nicely designed soft cover. The breezy title establishes a sense of informality carried through with humorous illustrations and comments that serve to allay the reader's anxiety about the prospects for being able to read electrocardiograms. The attractive overall design of the book is further complemented by the well-executed and appropriately used drawings of the heart and conduction system. The book begins with an introductory chapter and another devoted to hypertrophy and enlargement. The three-chapter section on arrhythmias and conduction disturbances is placed before the chapter on coronary heart disease. There is a chapter called "Finishing Touches" that contains well-chosen examples of miscellaneous conditions with electrocardiographic manifestations, and the book ends with a review chapter containing a simplified method for reading electrocardiograms and a set of review charts. There are a few minor inaccuracies that do not detract from the overall usefulness of the
The fluctuant nature of precipitating antibodies in dairy farmers.
Authors: Y Cormier, J Belanger
Journal: Thorax (1989)

Four hundred and forty five of 888 dairy farmers studied in an epidemiological survey four years previously were restudied to determine change in precipitins and in clinical features. Subjects answered the same questionnaire, which was filled in by the same nurse in the same winter months, and had blood withdrawn for precipitin analysis (double diffusion technique). Of the 445 subjects retested, 48 (10.8%) had been precipitin positive at the first study; of these, 34 remained positive four years later and 14 had reverted to negative. Twenty eight subjects previously negative for precipitins had become positive, so that 62 subjects in all were precipitin positive when restudied (13.9%). Of the 445 farmers, 369 were precipitin negative at both studies. The prevalence of symptoms, including cough, sputum production, wheezing, dyspnoea, and fever and chills, was similar for subjects who were consistently negative for precipitins and consistently positive and for those who changed from one to the other. Only one subject developed farmer9s lung; he had precipitins in both studies. This study shows a fluctuation in the precipitin state of dairy farmers, suggesting that more farmers have precipitins at least once in their lifetime than are identified by screening at a single point in time. Relatively few develop farmer9s lung or other respiratory symptoms. The presence of precipitins in a symptomless farmer appears to have no clinical importance.