tbuckley/cabot-search huggingface dataset:
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
Authors: W A Boisvert, R Santiago, L K Curtiss, R A Terkeltaub
Journal: Journal of Clinical Investigation (1998)

Chronic macrophage-mediated inflammation is central to atherosclerosis. A role of the monocyte chemotactic and activating C-C chemokine JE/monocyte chemotactic protein-1 has been proposed. However, the human C-X-C chemokines growth-regulated oncogene (GROalpha) and IL-8, and their shared receptor, CXCR-2, also can be expressed at sites of chronic inflammation. Because we detected CXCR-2 in the intima of human atherosclerotic lesions, we examined the role of leukocyte CXCR-2 expression in affecting lesion cellularity. Atherosclerosis-susceptible LDL receptor-deficient mice were irradiated, successfully repopulated with bone marrow cells that either lacked or expressed mIL-8RH (the homologue of CXCR-2), and fed an atherogenic diet for 16 wk. In recipients of mIL-8RH+/+ marrow, mIL-8RH colocalized with densely accumulated intimal MOMA-2 positive macrophages. In contrast, lesions in recipients of mIL-8RH-/- marrow lacked mIL-8RH, had little intimal MOMA-2 staining, and were less extensive. The mIL-8RH ligand KC/GROalpha was detected in the intima of all aortic atherosclerotic lesions. Thus, the capacity of leukocytes to express mIL-8RH, and associated intralesional expression of its ligands such as KC/GROalpha, mediated the intimal accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.
Influnce of the preservation damage on the intraoperative blood products usage during orthotopic liver transplantation (OLT)
Authors: J. Moreno, F. Acosta, J.S. Ortaga, A. Olivares, R.F. Contreras, P. Parrilla, F.S. Bueno, P. Ramirez, A.S. Pefia, A.R. Ribó
Journal: Journal of Hepatology (1991)
The diagnosis of multiple accessory pathways in the Wolff-Parkinson-White syndrome from the surface electrocardiogram during sinus rhythm
Authors: Jacob Atie, Pedro Brugaca, Joep L.R.M. Smeets, Fernando E.S. Cruz, Ayrton Peres, Mauricio Duque, Hein J.J. Wellens
Journal: Journal of the American College of Cardiology (1990)
Abstract IA8: Genetic approaches to cancer
Authors: Nicole L. Solimini, Andrea L. Bredemeyer, Mamie Z. Li, Rameen Beroukhim, Matthew Meyerson, Stephen J. Elledge, Natalya N. Pavlova, Qikai Xu, Craig H. Mermel, Anthony C. Liang, Michael R. Schlabach, Ji Luo, Anna E. Burrows, Anthony N. Anselmo
Journal: Cancer Research (2012)

Abstract Breast cancer is a collection of diseases with distinct clinical behaviors and underlying genetic causes. We have searched genetically for genes that have cancer relevant phenotypes including genes that alter cellular proliferation, cellular transformation, cell survival, cellular senescence, and genes that are essential for the proliferation of cancer cells. We have approached this by the generation of libraries of shRNAs for loss of function experiments and libraries of ORFs for gain of function experiments. We will discuss these technologies and how they can be applied to the functional dissection of genes important for breast cancer. Citation Format: Nicole L. Solimini, Andrea L. Bredemeyer, Mamie Z. Li, Rameen Beroukhim, Matthew Meyerson, Stephen J. Elledge, Natalya N. Pavlova, Qikai Xu, Craig H. Mermel, Anthony C. Liang, Michael R. Schlabach, Ji Luo, Anna E. Burrows, Anthony N. Anselmo. Genetic approaches to cancer [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr IA8.
Ampicillin in Pancreatitis
Authors: ED CADMAN
Journal: Annals of Internal Medicine (1976)

ExcerptTo the editor: I wish to bring to the attention of Craig, Dordal, and Myles, ("The Use of Ampicillin in Acute Pancreatitis,"Ann Intern Med83:831-832, 1975), that, contrary to their statement "that no published controlled studies . . . evaluating prophylactic antibiotics in acute pancreatitis have been heretofore published," a previous randomized prospective study evaluating the use of prophylactic antibiotics in the treatment of acute pancreatitis was reported 10 months earlier by Howes, Zuidema, and Cameron ("Evaluation of Prophylactic Antibiotics in Acute Pancreatitis,"J Surg Res18:197-200, 1975). There were 48 patients in the antibiotic group (44 received ampicillin,...
Nasal endothelial interleukin‐10 expression is negatively correlated with nasal symptoms after allergen provocation
Authors: B. Muller, E. J. J. De Groot, I. J. M. Kortekaas, W. J. Fokkens, C. M. Van Drunen
Journal: Allergy (2009)

Despite major efforts, factors that predict or correspond to the level of allergic symptoms remain elusive. Given our previous observations of mucosal interleukin-10 (IL-10) expression by local tissue cells and its described role as immune modulator, we hypothesized that, in allergic rhinitis, nasal mucosal IL-10 expression could influence the severity of symptoms.In this study, we investigated endothelial IL-10 expression in nasal mucosa of healthy- and house dust mite allergic patients, both before and after provocation, and under nasal steroid therapy. Nasal turbinate biopsies were taken from healthy individuals as well as from house dust mite allergic patients, both before and after provocation. Allergic patients received fluticasone proprionate aqueous nasal spray or control treatment. In the allergic patients, endothelial IL-10 scores based on immunohistochemical stainings were correlated with allergic symptoms, measured by visual analog scores.At baseline, variable levels of endothelial IL-10 were detected in nasal biopsies. After nasal provocation, but not at baseline, endothelial IL-10 expression corresponded very closely to the allergic symptoms after allergen provocation. Low symptom scores were correlated with high endothelial IL-10 scores. This correlation disappeared after fluticason propionate treatment.There is a large variation in the level of endothelial IL-10 expression both in healthy individuals and in house dust mite allergic patients. Endothelial IL-10 expression may affect local immune reactions resulting in reduced levels of allergic symptoms.
Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.
Authors: S J Chen, A Zelent, J H Tong, H Q Yu, Z Y Wang, J Derré, R Berger, S Waxman, Z Chen
Journal: Journal of Clinical Investigation (1993)

Cytogenetic study of a patient with acute promyelocytic leukemia (APL) showed an unusual karyotype 46,xy,t(11;17) (q23;21) without apparent rearrangement of chromosome 15. Molecular studies showed rearrangements of the retinoic acid receptor alpha (RAR alpha) gene but no rearrangement of the promyelocytic leukemia gene consistent with the cytogenetic data. Similar to t(15;17) APL, all-trans retinoic acid treatment in this patient produced an early leukocytosis which was followed by a myeloid maturation, but the patient died too early to achieve remission. Further molecular analysis of this patient showed a rearrangement between the RAR alpha gene and a newly discovered zinc finger gene named PLZF (promyelocytic leukemia zinc finger). The fusion PLZF-RAR alpha gene found in this case, was not found in DNA obtained from the bone marrow of normals, APL with t(15;17) and in one patient with AML-M2 with a t(11;17). Fluorescence in situ hybridization using a PLZF specific probe localized the PLZF gene to chromosomal band 11q23.1. Partial exon/intron structure of the PLZF gene flanking the break point on chromosome 11 was also established and the breakpoint within the RAR alpha gene was mapped approximately 2 kb downstream of the exon encoding the 5' untranslated region and the unique A2 domain of the RAR alpha 2 isoform.
Review of abortion law demanded after abortion for cleft palate
Authors: R. Dobson
Journal: BMJ (2003)

Lawyers will next week ask the High Court for permission to begin a legal action that could lead to a tightening up of the abortion law and the definition of serious handicap.

Reverend Joanna Jepson and her lawyers are seeking the go-ahead to pursue a judicial review of a decision by West Mercia Police not to prosecute a doctor who performed a late abortion on a woman who, it is alleged, did not want a baby with a cleft palate. The woman has …
TCT-185 Association Between the Ankle-Brachial Index and the Severity of Coronary Artery Disease
Authors: Yong Kyu Park, Uk Jo, Seung Mo Kang, Shin-Eui Yoon, Hyun Woo Park, Young-Rak Cho, Gyung-Min Park, Jung-Min Ahn, Won-Jang Kim, Jong-Young Lee, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2012)
Placental Transfer of Sulfamethoxypyridazine
Authors: Mohsen Ziai, Maxwell Finland
Journal: New England Journal of Medicine (1957)

BARKER1 and Speert,2 in 1938, showed that sulfanilamide given to mothers before or during labor passed readily across the human placenta and could be demonstrated in umbilical-vein blood at the time of delivery. Subsequent studies by Speert3 , 4 indicated that sulfathiazole and sulfadiazine also traversed the placenta. He found that when these drugs were given orally during labor, they might be irregularly absorbed from the gastrointestinal tract, and therefore suggested their use intravenously3; when sodium sulfadiazine was so administered to mothers an equilibrium was established in about three hours between maternal and fetal blood. He suggested such treatment of the . . .
Osteopetrosis (Albers-Schonberg): Appearance on Three-Phase Bone Scintigraphy
Authors: DAPHNE ROITBERG, RICHARD A. VITTI, MARK M. MASLACK
Journal: Clinical Nuclear Medicine (1997)

A 47-year-old woman with osteopetrosis, diagnosed incidentally 20 years earlier on a routine pre-employment chest radiograph, presented with painful knees of approximately 3 months' duration. A three-phase bone scan of the knees was performed using Tc-99m MDP for pathophysiologic evaluation of the patient's disease process and to rule out a complication such as fracture or osteomyelitis. The bone scan revealed bilateral hyperemia, as well as abnormal radiotracer accumulation in the distal femurs and proximal tibiae bilaterally, a reflection of her disease. No fractures or signs of modeling defects (i.e., Erlenmeyer flask), clubbing, or metaphyseal splaying were demonstrated. This suggested that she most likely had type 1 autosomal dominant disease variant by scintigraphic evaluation, and furthermore confirmed that the three-phase bone scan was a useful diagnostic test to characterize and distinguish between the two main phenotypic forms of the autosomal dominant form of osteopetrosis.
Development of diabetic nephropathy in the Milan normotensive strain, but not in the Milan hypertensive strain: Possible permissive role of hemodynamics
Authors: Giuseppe Pugliese, Flavia Pricci, Paola Barsotti, Carla Iacobini, Carlo Ricci, Giovanna Oddi, Giulio Romeo, Gaetano Leto, Giuseppe Marano, Mariella Sorcini, Massimo Sabbatini, Giorgio Fuiano, Umberto Di Mario, Francesco Pugliese
Journal: Kidney International (2005)
Removing the pH From Physician Phrases
Authors: Richard E. Neiberger
Journal: JAMA (1991)

<h3>To the Editor.</h3> —I was helping a group of medical students work through a complex acid-base problem last week. I recognized again how difficult it is for a novice to understand a complex physiological abnormality when the perturbed variable (H<sup>+</sup>concentration) is expressed as the log of the reciprocal of the concentration: pH = log(1/[H<sup>+</sup>]), or the negative log of the concentration. In the days of Arrhenius, Severing-haus, and Henderson-Hasselbalch, concentrations expressed in nanomoles presented some difficulty for calculations. This is no longer true. In the 1990s, it is just as easy to consider hydrogen-ion concentration as 20, 40, or 60 nmol/L as it is to consider potassium as 3, 4, or 5 mmol/L. Using pH once served a useful purpose, like the horse and buggy, logarithms, and the slide rule. In the 1990s, pH no longer serves a useful purpose in clinical medicine. The concept of pH only adds confusion
Purine Phosphoribosyltransferase in Gilles de la Tourette Syndrome
Authors: Melvin H. Van Woert, Lily C. Yip, M. Earl Balis
Journal: New England Journal of Medicine (1977)

Gilles de la Tourette syndrome is a neurologic disorder in which there are both motor and behavioral abnormalities, approximately 75 per cent of the patients are male and the onset of the disease is usually between two and 14 years of age.1 , 2 Recently, a genetic origin has been suggested on the basis of an approximate 10 per cent family history of the disease,2 , 3 with numerous reports describing both parent and offspring with the syndrome4 , 5 and a high rate in Ashkenazic Jews and a low rate in the black population. The initial symptom is usually involuntary ticlike muscle movements. With progression . . .
Poor Asthma Control In Older Adults Is Associated With Reduced Adherence To Controller Therapies and Inability To Afford Medications
Authors: Jessica Tan, David I. Bernstein, Cheryl Koff Bernstein, Patrick Ryan, Jonathan A. Bernstein, Banu Kesavalu, Manuel S. Villareal, Andrew M. Smith, Peter Lenz, Tolly Epstein
Journal: Journal of Allergy and Clinical Immunology (2014)
Effects of antihistamines on the lung vascular response to histamine in unanesthetized sheep. Diphenhydramine prevention of pulmonary edema and increased permeability.
Authors: K L Brigham, R E Bowers, P J Owen
Journal: Journal of Clinical Investigation (1976)

To see whether antihistamines could prevent and reverse histamine-induced pulmonary edema and increased lung vascular permeability, we compared the effects of a 4-h intravenous infusion of 4 mug/kg per min histamine phosphate on pulmonary hemodynamics, lung lymph flow, lymph and plasma protein content, arterial blood gases, hematocrit, and lung water with the effects of an identical histamine infusion given during an infusion of diphenhydramine or metiamide on the same variables in unanesthetized sheep. Histamine caused lymph flow to increase from 6.0+/-0.5 to 27.0+/-5.5 (SEM) ml/h (P less than 0.05), lymph; plasma globulin concentration ratio to increase from 0.62+/-0.01 to 0.67+/-0.02 (P less than 0.05), left atrial pressure to fall from 1+/-1 to -3+/-1 cm H2O (P less than 0.05), and lung lymph clearance of eight protein fractions ranging from 36 to 96 A molecular radius to increase significantly. Histamine also caused increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2. Diphenhydramine (3 mg/kg before histamine followed by 1.5 mg/kg per h intravenous infusion) completely prevented the histamine effect on hematocrit, lung lymph flow, lymph protein clearance, and lung water content, and reduced histamine effects on arterial blood gases and pH. 6 mg/kg diphenhydramine given at the peak histamine response caused lymph flow and lymph: plasma protein concentration ratios to fall. Metiamide (10 mg/kg per h) did not affect the histamine lymph response. We conclude that diphenhydramine can prevent histamine-induced pulmonary edema and can prevent and reverse increased lung vascular permeability caused by histamine, and that histamine effects on lung vascular permeability are H1 actions.
Ambient Carbon Monoxide Associated with Reduced Risk of Hospital Admissions for Respiratory Tract Infections
Authors: Linwei Tian, Hong Qiu, Vivian C. Pun, Hualiang Lin, Erjia Ge, Jazz C. Chan, Peter K. Louie, Kin-fai Ho, Ignatius T. S. Yu
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Rationale: Recent experimental and clinical studies suggest that exogenous carbon monoxide (CO) at lower concentrations may have beneficial effects under certain circumstances, whereas population-based epidemiologic studies of environmentally relevant CO exposure generated mixed findings.Objectives: To examine the acute effects of ambient CO on respiratory tract infection (RTI) hospitalizations.Methods: A time series study was conducted. Daily emergency hospital admission and air pollution data in Hong Kong were collected from January 2001 to December 2007. Log-linear Poisson models were used to estimate the associations between daily hospital admissions for RTI and daily average concentrations of CO across three background air monitoring stations and three roadside stations, respectively, controlling for other traffic-related copollutants.Measurements and Main Results: CO concentrations were low during the study period with a daily average of 0.6 ppm in background stations and 1.0 ppm in roadside stations. Negative associations were found between ambient CO concentrations and daily hospital admissions for RTI. One ppm increase in background CO at lag 0–2 days was associated with −5.7% (95% confidence interval, −9.2 to −2.1) change in RTI admissions from the whole population according to single-pollutant model; the negative association became stronger when nitrogen dioxide or particulate matter with aerodynamic diameter less than 10 μm was adjusted for in two-pollutant models. The negative association seemed to be stronger in the adults than in the children and elderly.Conclusions: Short-term exposure to ambient CO was associated with decreased risk of hospital admissions for RTI, suggesting some acute protective effects of low ambient CO exposure on respiratory infection.
Public Funds and the Injured Motorcyclist-Reply
Authors: Timothy J. Bray
Journal: JAMA (1986)

In Reply.—  Dr Morris has recommended denial of state funds to pay for uninsured motorcycle injuries. However, he does not provide a viable option ofwhowill pay and support this multimillion dollar a year deficit. Just as smoking and drug abuse have absorbed a disproportionate health care dollar, so does the uninsured, alcohol-intoxicated motorcyclist. Luna et al1found very similar conclusions in that the intoxicated cyclist tends not to wear a helmet, to be at fault for an accident, and to have an increased risk for severe head injury. In conclusion, the body of evidence continues to build against this major expenditure of the health care dollar. Dr Morris and others have yet to prove in scientifically sound studies that intoxicated uninsured motorcyclists who do not wear helmets are safe, prudent consumers of the health care industry.  Conversely, Dr Vernon has diligently and explicitly outlined strong supporting evidence
The codes of man and beasts
Authors: David Premack
Journal: Behavioral and Brain Sciences (1983)

Abstract Exposing the chimpanzee to language training appears to enhance the animal's ability to perform some kinds of tasks but not others. The abilities that are enhanced involve abstract judgment, as in analogical reasoning, matching proportions of physically unlike exemplars, and completing incomplete (external) representations of action. The abilities that do not improve concern the location of items in space and the inferences one might make in attempting to obtain them. Representing items in space and making inferences about them could be done with an imaginal code, but representing relations and judging the relations between them, as in analogies, requires a more abstract code. Language training cannot instill such an abstract code, but for species that have the code to start with, it may enhance the animal's ability to use it.
The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissue-engineered blood vessels
Authors: Wen Zeng, Wei Yuan, Li Li, Jianhong Mi, Shangcheng Xu, Can Wen, Zhenhua Zhou, Jiaqiang xiong, Jiansen Sun, Dajun Ying, Mingcan Yang, Xiaosong Li, Chuhong Zhu
Journal: Biomaterials (2009)
Arrhythmias and Cardiac Arrest Induced By Metaraminol (Aramine) Bitartrate
Authors: Orson Smith
Journal: JAMA (1960)

The use of vasopressor agents for the treatment of hypotensive states has become widespread. The introduction of mephentermine, metaraminol, and methoxamine, agents that can be given either intravenously or intramuscularly, has further encouraged this trend.<sup>1</sup>The value of these agents is unquestioned and many lives have been saved through their use. However, the use of pressor amines is accompanied by the possibility of producing arrhythmias. The present case report concerns the production of serious atrial and ventricular arrhythmias and, indeed, cardiac arrest by the intravenous administration of 10 mg. of metaraminol (Aramine) bitartrate. <h3>Report of a Case</h3> A 49-year-old housewife was admitted to Emory University Hospital Dec. 2, 1959, for elective gastrotomy. She had been hospitalized two months previously with pneumonia of the lower lobe of the right lung. At that time, she complained of some discomfort in the epigastrium and a gastrointestinal series showed what appeared to be
Carbon Dioxide–Induced Narcosis due to Dry Ice Exposure in a Patient With Sleep Apnea
Authors: Jerrold B. Leikin
Journal: Annals of Internal Medicine (2009)

Letters3 March 2009Carbon Dioxide–Induced Narcosis due to Dry Ice Exposure in a Patient With Sleep ApneaJerrold B. Leikin, MD, Joseph F. Mitton, MD, and Thomas Freedom, MDJerrold B. Leikin, MDFrom Glenbrook Hospital, Glenview, IL 60026.Search for more papers by this author, Joseph F. Mitton, MDFrom Glenbrook Hospital, Glenview, IL 60026.Search for more papers by this author, and Thomas Freedom, MDFrom Glenbrook Hospital, Glenview, IL 60026.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-5-200903030-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Dry ice is solid carbon dioxide. In enclosed spaces, evaporated carbon dioxide can displace oxygen to produce asphyxia.Objective: To report a case of carbon dioxide–induced asphyxia after exposure to 500 lb of dry ice in an enclosed minivan.Case Report: A 70-year-old, obese, nonsmoking male with a history of type 2 diabetes mellitus, hypertension, and obstructive sleep apnea for 3 years (treated with home continuous positive airway pressure) presented to an emergency department after being found unconscious in his minivan. He was revived with oxygen. The patient said that before losing consciousness he was “hyperventilating” but could not ...References1. Tokaoka M, Morinag AK, Karakowa IC. A case report of acute carbon dioxide intoxication by dry ice. Chudoku Kenkyu. 1988;1:87. Google Scholar2. White DP. Sleep apnea. Proc Am Thorac Soc. 2006;3:124-8. [PMID: 16493160] CrossrefMedlineGoogle Scholar3. Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: pathophysiology and treatment. Chest. 2007;131:595-607. [PMID: 17296668] CrossrefMedlineGoogle Scholar4. Mokhlesi B, Tulaimat A. Recent advances in obesity hypoventilation syndrome. Chest. 2007;132:1322-36. [PMID: 17934118] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Glenbrook Hospital, Glenview, IL 60026.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 March 2009Volume 150, Issue 5Page: 361-362KeywordsAsphyxiaCarbon dioxideEdemaOxygenResearch laboratoriesSleep apneaSyncopeToxicityType 2 diabetes ePublished: 3 March 2009 Issue Published: 3 March 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...