tbuckley/cabot-search huggingface dataset:
Abstract 3824: Induction of potent antitumor immunity by intratumoral injection of mT-bet transduced dendritic cells
Authors: Yanyan Qu, Michael W. Lipscomb, Jennifer L. Taylor, Walter J. Storkus
Journal: Cancer Research (2010)

Abstract T-bet is a T-box transcription factor (Tbx21) previously identified as a master regulator of Type-1 polarization in T cells. We have previously demonstrated that ectopic expression of hT-bet converts dendritic cells (DC) into Type 1-biasing APCs. In the current study, we investigated whether mouse DC overexpressing mT-bet promote superior Type 1 anti-tumor T cell responses when applied as an intratumoral therapy. CD11c+ DCs were then purified and transduced with recombinant adenovirus to express high levels of mT-bet. DC. mT-bet stimulated stronger Tc1 and Th1 T cell responses when compared with control DC and retained the capacity to kill and then uptake tumor cells/debris, allowing for the cross-priming of specific T cell responses in vitro. Surprisingly, in contrast to human DC. T-bet, CD40L-activated DC. mT-bet produced elevated levels (vs. control DC) of IL-12p70/TNF-α. DC. mT-bet exerted potent anti-tumor activity in the (day 7 established) s.c. CMS4 sarcoma after intratumoral administration. These anti-tumor effects were mediated primarily by Tc1 cells, however, both CD4+ T cells and NK cells appeared to also be involved in therapeutic response. In situ imaging suggested that DC. mT-bet treatment inhibited the accumulation of CD11b+Gr1+ myeloid-derived suppressor cells and tumor-associated vascular structures. Collectively, these findings suggest that DC. mT-bet-based therapy has the potential to promote superior Type-1 anti-tumor immunity in vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3824.
ETIOLOGY OF NON-MALIGNANT RECTAL STRICTURE IN WOMEN.
Authors: REUBEN PETERSON
Journal: JAMA (1900)

Complete or partial narrowing of the rectum, having its origin in developmental anomalies, will not be considered in this paper. Acquired rectal strictures are much more common in women than in men. Gosselin and Dubar<sup>1</sup>estimate the proportion as 4 women to 1 man. Of the cases of rectal strictures collected by Juliusburger<sup>2</sup>, there were 103 women and 15 men, or about 7 of the former to 1 of the latter. Out of 110 cases treated by Allingham<sup>3</sup>in St. Mark's Hospital, there were 92 females to 18 males, or in the proportion of 5 to 1. The ratio is even greater in Cripp's<sup>4</sup>series of 70 cases, as out of this number there were only 7 males, or in the proportion of 9 to 1. Carré's statistics in 266 collected cases show 4 women to 1 man afflicted with the disease. The same ratio was
Haemodynamic Effects of Propranolol
Authors: M. Stannard, G. Sloman
Journal: BMJ (1967)

March 1'967 Correspondence thyrotoxicosis and taking chlordiazepoxide the T3 uptake value lay in the normal (or low normal) range, and the "'I tracei test showed depressed thyroid uptake.We can find no mention of this effect in the literature and feel it appropriate to draw attention to it.The suggestion (as put forward for some other drugs-for example, contraceptive pills) that chiordiazepoxide may interfere with the dissociation of protein-bound thyroxine into free thyroxine could explain the lowered T3 uptake, but not the depressed thyroid "'I uptake.We therefore think It possible that chlor- diazepoxide acts as an antithyroid drug (this could explain both effects)..-I am, etc.,
Inhalation of Hydrocortisone Acetate for Bronchial Asthma
Authors: W. H. Helm, F. Heyworth
Journal: BMJ (1958)

B JoRNAL and the chance of toxic effect is therefore much less.The optimum dosage is uncertain, but it probably varies from patient to patient.Little or no benefit is likely to be obtained from this form of treatment in patients with established chronic bronchitis.We are indebted to the late Dr. W. J. Dunn, Dr. J. Shafar, and many other doctors for their co-operation; to Dr. G. Behr and Mr. H.Lawrie for carrying out the biochemical estimations
Analysis of an Open Electrocardiograph Referral Service for Family Doctors
Authors: C. M. Morgans, D. B. Gillings, N. G. Pearson, D. B. Shaw
Journal: BMJ (1970)

The results of a questionary to investigate an open electrocardiograph (E.C.G.) service for family doctors suggest that the service is useful in diagnosis (26% of the E.C.G. reports were unexpected) and in management (the result of the E.C.G. led to specific treatment or alteration to regimen in 22% of cases and in a further 46% to reassurance). The results suggest that during the 45 weeks of the study many outpatient appointments were avoided.Undoubtedly an open E.C.G. service allows the family doctor to give a quicker and better service to his patients. For this reason and because of operational benefits to the hospital the service must be recommended.
Vibrio comma and pH
Authors: HOBART A. REIMANN
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 August 1973Vibrio comma and pHHOBART A. REIMANN, M.D.HOBART A. REIMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-2-290_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent letter (1) and article (2) (Bull WHO47:31-36, 1972) no reference was made to statements on gastrointestinal hydrogen ion concentration and cholera that were published 27 years ago (3): "Perhaps another factor plays a role in the susceptibility to cholera. Since the Chinese diet in general is 97% vegetarian, the intestinal fluid tends to be alkaline, providing a medium favorable toV[ibrio] comma. The addition of protein . . . to the diet may lower the hydrogen ion concentration to a point at which the comma bacillus cannot live."...References1. BROITMANZAMCHECK SN: Gastric acidity and cholera (letter). Ann Intern Med 78:780, 1973 LinkGoogle Scholar2. SACKPIERCEHENNESSEY GNK: Gastric acidity in cholera and noncholera diarrhea. Bull WHO 47:31-36, 1972 MedlineGoogle Scholar3. REIMANNCHANGCHU HGL: Asiatic cholera. Clinical study and experimental therapy with streptomycin. Am J Trop Med 26:631-647, 1946 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1973Volume 79, Issue 2Page: 290-290KeywordsAttentionBacillusCholeraDietProteinsVibrio cholerae Issue Published: 1 August 1973 PDF DownloadLoading ...
Plasma lipid and coagulation factor concentrations in insulin dependent diabetics with microalbuminuria.
Authors: S. L. Jones, C. F. Close, M. B. Mattock, R. J. Jarrett, H. Keen, G. C. Viberti
Journal: BMJ (1989)

To determine whether insulin dependent diabetics with microalbuminuria have significant abnormalities in concentrations of lipoproteins, apolipoproteins AI and B, fibrinogen, and clotting factor VII which could result in increased cardiovascular risk.Case-control study.Outpatient department of a metabolic ward.Group of 20 insulin dependent diabetics with urinary albumin excretion rates greater than 30 micrograms/min (microalbuminuria) and 20 individually matched insulin dependent diabetics with normal urinary albumin excretion rates (below 30 micrograms/min) matched for age, sex, and duration of diabetes.Fasting venous blood samples were taken for determination of concentrations of glucose, glycated haemoglobin, lipoproteins, apolipoproteins AI and B, fibrinogen, and factor VII. Height, weight, arterial pressure, and usual insulin dose were recorded, and each patient was given a dietary questionnaire to be completed at home.Comparison of blood pressure and concentrations of lipoproteins, apolipoproteins AI and B, and fibrinogen in the diabetics with microalbuminuria and the controls.Patients with microalbuminuria had significantly higher concentrations of low density lipoprotein cholesterol (mean 3.33 (SE 0.20) v 2.84 (0.12) mmol/l) and very low density lipoprotein cholesterol (0.30 (0.05) v 0.17 (0.03) mmol/l) than controls but significantly lower concentrations of high density lipoprotein 2 subfraction cholesterol (0.32 (0.04) v 0.54 (0.04) mmol/l). Concentrations of total triglyceride (1.11 (0.14) v 0.68 (0.08) mmol/l), very low density lipoprotein triglyceride (0.56 (0.10) v 0.30 (0.05) mmol/l), apolipoprotein B (0.88 (0.06) v 0.67 (0.03) g/l) and fibrinogen (2.2 (0.1) v 1.9 (0.1) g/l), and diastolic arterial pressure (80 (2) v 74 (2) mm Hg), were also higher in patients with microalbuminuria.Cardiovascular risk factors--namely, disturbances in lipoprotein and apolipoprotein concentrations, increased fibrinogen concentration, and increased arterial pressure--are already present in insulin dependent diabetics with microalbuminuria. The increased risk of coronary heart disease in patients with clinical proteinuria may result from prolonged exposure to these risk factors, which are present before any impairment of renal function.
760 RESISTANT MUTATION IN HEPATITIS C VIRUS NS5B POLYMERASE GENE IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION GENOTYPE 1B TREATED WITH PEGYLATED IFN AND RIBAVIRIN
Authors: V. Balan, A. Pivert, V. Dumbrava, P. Veillon, H. Le Guillou-Guillemette, F. Lunel-Fabiani
Journal: Journal of Hepatology (2010)
Myelinolysis after Correction of Hyponatremia
Authors: Robert Laureno
Journal: Annals of Internal Medicine (1997)

Myelinolysis is a neurologic disorder that can occur after rapid correction of hyponatremia.Initially named "central pontine myelinolysis," this disease is now known to also affect extrapontine brain areas. Manifestations of myelinolysis usually evolve several days after correction of hyponatremia. Typical features are disorders of upper motor neurons, spastic quadriparesis and pseudobulbar palsy, and mental disorders ranging from mild confusion to coma. Death may occur. The motor and localizing signs of myelinolysis differ from the generalized encephalopathy that is caused by untreated hyponatremia. Experiments have duplicated the clinical and pathologic features of myelinolysis by rapidly reversing hyponatremia in animals.Myelinolysis is more likely to occur after the treatment of chronic rather than acute hyponatremia and is more likely to occur with a rapid rate of correction. The exact pathogenesis of myelinolysis has not been determined. Optimal management of hyponatremic patients involves weighing the risk for illness and death from untreated hyponatremia against the risk for myelinolysis due to correction of hyponatremia.Experiments in animals and clinical experience suggest that correction of chronic hyponatremia should be kept at a rate less than 10 mmol/L in any 24-hour period.
Removal of Ovaries During a Hysterectomy
Authors: Walter L. Palmer
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The purpose of this letter is to protest the reply given by an unnamed consultant to the question (<i>JAMA</i><b>174</b>:920 [Oct. 15] 1960) as to whether "the ovaries should be removed in women 40 or 45 years of age who undergo a total hysterectomy and whose ovaries appear normal on gross inspection at the time of operation? It is assumed that these women, at the time of operation, have either large myomas, severe bleeding problems, or other adequate criteria for the hysterectomy, and show some symptoms of being at least in an early phase of the menopause." The writer concedes that "oophorectomy has been advocated on the grounds that ovarian function ceases and atrophy occurs soon after hysterectomy and that removal prevents the subsequent development of cancer of the ovary." The writer continues, "The arguments against removal are (1) that many such women still menstruate; (2)
Are randomised controlled trials in the BMJ different?
Authors: M. Egger, C. Bartlett, P. Juni
Journal: BMJ (2001)

<h3>Abstract</h3> New Zealand, a geographically remote Pacific island with easily sealable borders, implemented a nation-wide lockdown of all non-essential services to curb the spread of COVID-19. New Zealand has now effectively eliminated the virus, with low numbers of new cases limited to new arrivals in managed quarantine facilities at the border. Here, we generated 649 SARS-CoV-2 genome sequences from infected patients in New Zealand with samples collected between 26 February and 22 May 2020, representing 56% of all confirmed cases in this time period. Despite its remoteness, the viruses imported into New Zealand represented nearly all of the genomic diversity sequenced from the global virus population. The proportion of D614G variants in the virus spike protein increased over time due to an increase in their importation frequency, rather than selection within New Zealand. These data also helped to quantify the effectiveness of public health interventions. For example, the effective reproductive number, R<sub>e</sub>, of New Zealand's largest cluster decreased from 7 to 0.2 within the first week of lockdown. Similarly, only 19% of virus introductions into New Zealand resulted in a transmission lineage of more than one additional case. Most of the cases that resulted in a transmission lineage originated from North America, rather than from Asia where the virus first emerged or from the nearest geographical neighbour, Australia. Genomic data also helped link more infections to a major transmission cluster than through epidemiological data alone, providing probable sources of infections for cases in which the source was unclear. Overall, these results demonstrate the utility of genomic pathogen surveillance to inform public health and disease mitigation.
Hyperinsulinemia in Macrosomic Infants of Nondiabetic Mothers
Authors: Bente Hoegsberg, Philip A Gruppuso, Donald R Coustan
Journal: Diabetes Care (1993)

Objective— We tested the hypothesis that macrosomic infants of nondiabetic mothers are more likely to have hyperinsulinemia and increased subcutaneous fat. Research Design and Methods— Plasma insulin concentrations were measured in cord blood from 50 macrosomic infants and 32 normal-sized (control), term infants. All mothers had had a normal 50-g 1-h GCT. Skin-fold measurements of the triceps and subscapular area were done on 44 macrosomic infants with a Halpern caliper. Results— No difference was observed in GCT between mothers of macrosomic (5.8 ± 1.0 mM) and normal (5.7 mM) infants. The insulin level in macrosomic infants (18.75 ± 19.08 μU/ml) was significantly higher than in control infants (8.67 ± 6.64 μU/ml). Macrosomia was a predictor of hyperinsulinemia and vice versa (R2 = 0.26). Maternal height, prepregnancy weight, and weight gain were predictors for macrosomia (R2 = 0.26). No differences were noted in anthropometric measurements between hyperinsulinemic and normoinsulinemic infants. Conclusions— A subset of macrosomic infants have hyperinsulinemia. Maternal anthropometric factors as well as hyperinsulinemia are correlated with macrosomia. The macrosomia may be causally related to the high insulin levels.
Pegylated interferon-associated retinopathy is frequent in hepatitis C virus patients with hypertension and justifies ophthalmologic screening
Authors: Stela Vujosevic, Diego Tempesta, Franco Noventa, Edoardo Midena, Giada Sebastiani
Journal: Hepatology (2012)

Treatment with pegylated interferon alpha (PegIFNα) and ribavirin is still regarded as the standard of care for chronic hepatitis C virus (HCV). Retinopathy has been occasionally described but prospective, longitudinal data are lacking. We investigated the frequency and clinical significance of retinopathy during therapy with PegIFNα and ribavirin in 97 consecutive HCV patients. In all, 54 (55.7%) and 43 (44.3%) patients were treated with PegIFNα 2a and PegIFNα 2b, respectively. Ophthalmologic examination was performed before therapy (baseline), at 3 and 6 months (3T and 6T, respectively) of therapy, and 3 months after the end of therapy (3ET). All patients underwent the baseline and 3T examination, 95.9% and 90.7% of patients underwent 6T and 3ET examination, respectively. Overall, 30.9% of patients developed retinopathy, as defined by the presence of cotton wool spots and/or retinal hemorrhages. Variables significantly associated with retinopathy during treatment were age (P = 0.004), metabolic syndrome (P = 0.05), hypertension (P < 0.0001), cryoglobulinemia (P = 0.05), and preexisting intraocular lesions at baseline (P = 0.01). By multivariate analysis, the only variable independently associated with PegIFNα-associated retinopathy was hypertension (hazard ratio [HR] = 4.99, 95% confidence interval [CI] 2.29-10.89). The frequency of retinopathy was significantly higher in hypertensive patients versus those without hypertension at all timepoints (18.5% versus 5.7% at baseline, P = 0.05; 48.1% versus 15.7% at 3T, P = 0.0009; 68.0% versus 19.1% at 6T, P < 0.0001; 32.0% versus 6.2%, P = 0.0005 at 3ET). In one (1.1%) hypertensive patient, who developed bilateral branch retinal vein occlusion at 6T, the therapy was discontinued. A cost analysis showed that screening for PegIFNα-associated retinopathy was cost-effective as compared with thyroid-stimulating hormone screening.Retinopathy is frequent during treatment with PegIFNα and ribavirin, especially in hypertensive patients, who may develop serious complications. Screening for PegIFNα-associated retinopathy should be recommended for HCV patients with hypertension.
Mandatory Reporting of HIV Testing Would Deter Men From Being Tested
Authors: Susan M. Kegeles
Journal: JAMA (1989)

<h3>To the Editor.—</h3> People at risk for acquired immunodeficiency syndrome (AIDS) are less likely to seek testing when it is offered confidentially rather than anonymously.<sup>1,2</sup>Some propose that positive test results be reported to public health officials and that testing be required to receive specific health care services. However, this may draw people away from testing because of concerns about loss of health insurance and discrimination. Some might forgo health care if testing was required.<sup>3</sup> <h3>Study.—</h3> Our longitudinal sample of homosexual men (N = 574) has been described previously.<sup>4</sup>The majority (56.2%) have obtained human immunodeficiency virus antibody testing. Respondents were presented with two scenarios (they are seeking care for AIDS/AIDS-related complex symptoms and seeking testing for venereal disease) and were asked if they would (1) consent to antibody testing if results had to be reported to public health officials and (2) seek health care if testing was
Id3 Knockout Mice as a New Model for Sjögren's Syndrome
Authors: Marjan A. Versnel
Journal: Immunity (2004)

Id3−/− mice were found to have autoantibodies, lymphocytic infiltrates in, and decreased secretion by exocrine glands. Similar symptoms are found in primary Sjögren's Syndrome. In this issue of Immunity, Li and colleagues (Li et al. 2004Li H. Dai M. Zhuang Y. Immunity. 2004; 21 (, this issue): 551-560Abstract Full Text Full Text PDF PubMed Scopus (99) Google Scholar) suggest an important role for Id3 function in T cell development and Sjögren's Syndrome.
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.
Authors: M Shlomchik, M Mascelli, H Shan, M Z Radic, D Pisetsky, A Marshak-Rothstein, M Weigert
Journal: The Journal of Experimental Medicine (1990)

The proximate cause of autoantibodies characteristic of systemic autoimmune diseases has been controversial. One hypothesis is that autoantibodies are the result of polyclonal nonspecific B cell activation. Alternatively, autoantibodies could be the result of antigen-driven B cell activation, as observed in secondary immune responses. We have approached this question by studying monoclonal anti-DNA autoantibodies derived from unmanipulated spleen cells of the autoimmune MRL/lpr mouse strain. This analysis shows that anti-DNAs, like rheumatoid factors (19), are the result of specific antigen-driven stimulation. In addition, correlation of sequences with fine specificity shows that: (a) somatic mutations can cause specificity for dsDNA and that such mutations are selected for; (b) arginine residues play an important role in determining specificity; and (c) anti-idiotypes that recognize the majority of anti-DNA are probably not specific for any one family of V regions.
Abstract 3475: Progranulin as a prognostic biomarker of advanced epithelial ovarian cancer.
Authors: Sharon Fitzgerald, Minshu Yu, John Hays, Nicola Di Santo, Laura Havrilesky, Elise Kohn
Journal: Cancer Research (2013)

Abstract Late diagnosis and early recurrence make epithelial ovarian cancer (EOC) the leading cause of gynecologic cancer death in the US. Indicators of early relapse may allow triage of high-risk patients to earlier therapy. Progranulin (PGRN) is a growth and survival factor overexpressed in EOC. We hypothesize that elevated serum (s)PGRN concentrations after clinical complete response (CCR) to primary platinum and taxane-based combination chemotherapy prognosticates disease recurrence and decreased survival in advanced EOC patients. We previously demonstrated high plasma (p)PGRN concentration (cutoff 59ng/ml) at first CCR distinguished early from late recurrence and predicted long-term survival (ROC AUC=0.944; sensitivity 93%; specificity 100%). In multivariate analysis, high pPGRN concentration predicted early recurrence (HR=23.5; 95%CI: 2.49-221; P&amp;lt;0.006). As PGRN is cleaved into proinflammatory granulins by neutrophil elastase, we wished to investigate the reliability of sPGRN as a biomarker. We compared PRGN concentrations in ten blinded, paired serum and plasma samples, using commercial PRGN ELISA assays; paired two-tailed t-test demonstrated comparability (P=0.90, R2= 0.002). A cohort of 35 blinded serum samples from a different institution was analyzed using the ELISA. The optimal dichotomization concentration of sPGRN, 49.5ng/ml, was determined by ROC statistics at a specificity of 90%, and applied to outcome analyses using Cox proportional hazards and Kaplan-Meier modeling. This PGRN cutoff significantly differentiated progression-free survival (PFS; P=0.0013). Subjects with low sPGRN had 100% survival (OS) at 2 years (N=11; range 2-12). Further validation of PGRN's discriminatory value could lead to its clinical investigation as a prognostic biomarker to stratify those at high risk for recurrence to closer monitoring or maintenance therapy, as well as its examination as a predictive biomarker for response to initial therapy. Citation Format: Sharon Fitzgerald, Minshu Yu, John Hays, Nicola Di Santo, Laura Havrilesky, Elise Kohn. Progranulin as a prognostic biomarker of advanced epithelial ovarian cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3475. doi:10.1158/1538-7445.AM2013-3475
APPLICATION OF THE TIMI RISK SCORE, A SIMPLE BEDSIDE TOOL, FOR TIMING OF DISCHARGE AFTER FIBRINOLYSIS OR PRIMARY ANGIOPLASTY FOR ST-ELEVATION MI IN THE EXTRACT-TIMI 25 AND TRITON-TIMI 38 TRIALS
Authors: Sean R. Wilson, Stephen D. Wiviott, Elliott M. Antman, Robert P. Giugliano, Sabina A. Murphy, Sarah Sloan, Eugene Braunwald, David A. Morrow
Journal: Journal of the American College of Cardiology (2010)