tbuckley/cabot-search huggingface dataset:
Micro-determination of cyclic AMP levels in human epidermis, dermis and hair follicles
Authors: K. YOSHIKAWA, K. ADACHI, V. LEVINE, K.M. HALPRIN
Journal: British Journal of Dermatology (1975)

Journal Article Micro‐determination of cyclic AMP levels in human epidermis, dermis and hair follicles Get access K. YOSHIKAWA, K. YOSHIKAWA Dermatology Service, Miami Veterans Administration Hospital and Department of Dermatology, University of Miami School of Medicine, Miami, Florida 33125, U.S.A Search for other works by this author on: Oxford Academic Google Scholar K. ADACHI, K. ADACHI Dermatology Service, Miami Veterans Administration Hospital and Department of Dermatology, University of Miami School of Medicine, Miami, Florida 33125, U.S.A address: K. Adachi, Dermatology Service. Miami VA Hospital, 1201 NW, l6th Street, Miami, Florida 33125, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar V. LEVINE, V. LEVINE Dermatology Service, Miami Veterans Administration Hospital and Department of Dermatology, University of Miami School of Medicine, Miami, Florida 33125, U.S.A Search for other works by this author on: Oxford Academic Google Scholar K.M. HALPRIN K.M. HALPRIN Dermatology Service, Miami Veterans Administration Hospital and Department of Dermatology, University of Miami School of Medicine, Miami, Florida 33125, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 3, 1 March 1975, Pages 241–248, https://doi.org/10.1111/j.1365-2133.1975.tb03072.x Published: 01 March 1975 Article history Accepted: 10 October 1974 Published: 01 March 1975
Analysis of BCR–ABL1 tyrosine kinase domain mutational spectra in primitive chronic myeloid leukemia cells suggests a unique mutator phenotype
Authors: H Grant, X Jiang, J Stebbing, L Foroni, C Craddock, M Griffiths, R E Clark, S O'Brien, J S Khorashad, G Gerrard, L Wang, J A E Irving, M Wang, L Karran, M J S Dyer, D Forrest, K Page, C J Eaves, A Woolfson
Journal: Leukemia (2010)
Psychological therapy in the NHS.
Authors: S Brandon
Journal: BMJ (1991)

such as "You mean to say, doctor, that you think this test might help my child, but it's against the law even if I want to pay for it out of mv own pocket."'Locally agreed protocols are more likely to be effective, but as Dr Jenkins points out these may be based on anecdotal evidence and personal experience.Apart from difficulties in drawing up protocols, other problems with protocols which will need to be addressed are their implementation (perhaps information technology will fulfill its promise in this respect), the long term assessment of their effectiveness, monitoring adherence, and the continuous medical effort that will be required to update them.Under whose responsibility will these fall?
Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion.
Authors: A Sen, J C Miller, R Reynolds, J T Willerson, L M Buja, K R Chien
Journal: Journal of Clinical Investigation (1988)

Previous studies have suggested that phospholipid degradation is closely associated with the development of sarcolemmal membrane injury. This study was initiated to characterize the effects of synthetic inhibitors of phospholipase activities using a cultured myocardial cell model in which arachidonic acid is liberated after treatment with the metabolic inhibitor, iodoacetate. Pretreatment with a steroidal diamine (U26,384) blocked the degradation of labeled phosphatidylcholine and the release of arachidonic acid in cultured myocardial cells during ATP depletion. Inhibition of phospholipid degradation by U26,384 prevented the development of sarcolemmal membrane defects and the release of creatine kinase from the cultured myocardial cells during ATP depletion. Pretreatment with U26,384 had no significant effect on the extent of ATP depletion after iodoacetate treatment, which indicates that the activity of this compound could not be simply ascribed to a sparing effect on ATP concentration. These results support the hypothesis that the development of sarcolemmal membrane injury and the associated loss of cell viability are causally related to progressive phospholipid degradation. In addition, these studies indicate that the release of arachidonic acid during ATP depletion is associated with the net loss of the phosphatidylcholine molecule.
Angiotensin II-induced contractions in human internal mammary artery: effects of cyclooxygenase and lipoxygenase inhibition
Authors: F Stanke-Labesque
Journal: Cardiovascular Research (2000)

Objective: This study investigated, in isolated human internal mammary artery, the involvement of the cyclooxygenase and the lipoxygenase pathways of arachidonic acid metabolism in the contraction induced by angiotensin II. Methods: Rings of human internal mammary arteries were suspended in organ baths for recording of isometric tension. In addition, the release of eicosanoids in response to angiotensin II (0.3 μM) was measured by enzyme immunoassay. Results: In human arterial rings without endothelial dependent relaxation in response to substance P or acetylcholine, the angiotensin II-induced contractions were significantly (P<0.05) reduced by 27% in the presence of GR32191 0.3 μM (thromboxane A2 (TXA2) receptor antagonist) but remained unchanged in the presence of dazoxiben 100 μM (thromboxane synthase inhibitor). In addition, angiotensin II failed to modify TXB2 and 6-keto-PGF1α production. These results suggest the contribution of a TXA2/PGH2 agonist other than TXA2 in angiotensin II-induced contractions. However, indomethacin increased (P<0.05) angiotensin II-mediated contractile response and cysteinyl leukotriene production, suggesting a redirection of arachidonic acid metabolism from the cyclooxygenase pathway to the lipoxygenase pathway. Indeed, the contractions induced by angiotensin II were inhibited (P<0.05) by phenidone 100 μM (cyclooxygenase and lipoxygenase inhibitor), baicalein 100 μM (5-, 12- and 15-lipoxygenases inhibitor), AA861 10 μM (5-lipoxygenase inhibitor) and MK571 1 μM (CysLT1 receptor antagonist). Cysteinyl leukotrienes were released in response to angiotensin II (pg/mg dry weight tissue: 32±9 (basal, n=6) vs. 49±9 (angiotensin II 0.3 μM, n=6), P<0.05). LTD4, and at a lesser degree LTC4, induced contractions of internal mammary artery and MK571 1 μM abolished the contraction to LTD4. Conclusions: This study suggests that the in vitro vasoconstrictor effects of angiotensin II in human internal mammary artery are enhanced at least in part by eicosanoids produced by the cyclooxygenase pathway, probably PGH2, acting on TXA2/PGH2 receptors, and by lipoxygenase-derived products, particularly cysteinyl leukotrienes acting on CysLT1 receptors.
Health-related fitness in physical education – 45 versus 90 minutes classes
Authors: Adilson Marques, Nuno Ferro, José Diniz, Francisco Carreiro da Costa
Journal: British Journal of Sports Medicine (2011)

The aim of the study was to quantify and assess the quality of the Physical Education (PE) lesson time spent by students in MVPA during 45 and 90 min classes. Data were collected through heart rate (HR) monitoring and SOFIT. The HR of 4 students from 6 teachers was assessed during 6 lessons (3 of 45 min and 3 of 90 min). PA levels of those students, as well as the lesson contexts in which they occurred, and teacher behaviours, were also observed and coded throughout each lesson, using SOFIT. A cluster analysis was made in reference to the students, establishing an individual comparison of different classes. Afterwards, an analysis was made in relation to the teachers. The average HR was 134±19 bpm for 45 and 131±9 bpm for 90 min classes. Teachers dedicated 60% and 57% of class time in MVPA, respectively to 45 and to 90 min lessons. In 45 min class lessons, 17% of the time was dedicated to promoting fitness and 32% to games. These percentages are superior to those of the 90 min class – 15% and 28%, respectively. As for PA intensity, despite the fact that there were no significant differences between the 45 and 90 min class, during 45 min there is a tendency for student HR to exceed 140 bpm for a longer time period. The results of the cluster analysis showed that games are the activities that characterise classes with moderate to vigorous intensity. A HR between 140 and 60 bpm is correlated with the time dedicated to fitness (r=0.64). No differences were found between the 45 and 90 min class periods, suggesting that from a pedagogical viewpoint, both options are adequate. Through SOFIT it was possible to verify that the activities with vigorous intensity happen in the periods in which the teacher had that intention, namely in the periods of fitness exercises and games. Thus, as for all teaching activities, the intensity of classes requires planning by PE teachers.
IRON ABSORPTION IN DOGS DURING ANEMIA DUE TO ACETYLPHENYLHYDRAZINE
Authors: W. B. Stewart, Philip S. Vassar, Robert S. Stone
Journal: Journal of Clinical Investigation (1953)

The mechanisms controlling the absorption of iron from the gastrointestinal tract have been under investigation for a number of years. It now appears that several factors can increase the absorption of iron above the small amounts normally absorbed. Early observations by Hahn, Bale, Lawrence, and Whipple (1) using radioactive isotopes of iron clearly demonstrated that the normal dog absorbed only small amounts of iron from the gastrointestinal tract, whereas the anemic iron deficient dog was capable of absorbing relatively large quantities of iron. This observation was extended to rats (2) and human subjects (3). It appeared, however, that in spite of adequate iron stores, excessive iron could be absorbed under certain circumstances. Patients with pernicious anemia, hemolytic anemia, and other anemias seemed to absorb more iron than normal when iron balance studies were done with the aid of radioactive isotopes (3). These types of anemia are generally associated with increased rather than decreased stores of iron. Furthermore, in several instances of prolonged anemia of various types which required multiple transfusion of blood over a number of years, there was deposited in the liver considerably more iron than had been administered by transfusion, suggesting an increase in the absorption of iron (4, 5). Studies in pigs deficient in pyridoxine (6) also suggested that the absorption of iron was increased, perhaps in this instance also because of the anemia which is regularly present. Some of the above mentioned observations sug
Patients with aortic aneurysm deserve higher priority
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

Patients with an abdominal aortic aneurysm are waiting too long for surgery, says a report from the UK national confidential inquiry into patient outcome and death.

Just over a fifth of patients (21%) with aortic aneurysm who were reviewed for the inquiry waited more than 12 weeks for an elective repair operation, even though their condition was “life threatening,”said the inquiry's chairman, Peter Simpson. He added, “Once a decision has been made to operate, this should be carried out as expeditiously as possible.”

The inquiry found that 18 patients who had emergency surgery for aortic aneurysm (out of 264) in …
Norway's Decentralized, Single-Payer Health System Faces Great Challenges
Authors: Magne Nylenna
Journal: JAMA (1995)

SOLIDARITY and equality form the ideological basis for the Scandinavian welfare state. In an international context the health care in Norway is characterized by a high level of education, proven medical competence, and equitable distribution of services. The main challenge for the future is an increasing gap between the capacity of the health services and the needs and expectations among patients. Waiting lists and rationing of health services represent significant threats to today's health care system in Norway. More resources and funding are needed to maintain the quality and public support and to avoid deterioration of the system. <h3>Norway—the Way to the North</h3> One of the northernmost countries in the world, Norway straddles the Arctic Circle, where the midnight sun shines during summer and the winters are dark and cold (Figure 1). Some 4.3 million inhabitants are scattered throughout an area of 324 000 km<sup>2</sup>, of which more than
Incidence of Febrile Neutropenia with Taxane-Based Systemic Therapy in Women with Early Stage Breast Cancer.
Authors: S. Alkhayyat, S. Dent, J. Verreault, A. Robinson, C. Germond, T. Vandenberg
Journal: Cancer Research (2009)

Abstract Background: Febrile neutropenia (FN) is one of the most significant toxicities experienced by patients treated with systemic therapy. Taxanes now play an integral role in the systemic therapy for women with early stage breast cancer. The most common taxane-containing regimen utilized in Ontario, Canada is 5-Fluorouracil/Epirubicin/Cyclophosphamide x 3 followed by Docetaxel x 3 (FEC-D). PACS 01 reported a febrile neutropenia (FN) rate of 11.2% in the FEC-D arm. In our clinical practice, clinicians have noted a much higher rate of FN. We report the FN rate with the use of FEC-D in women with early stage breast cancer treated at tertiary care centers in Ontario.Methods: All women with early stage breast cancer who were treated with FEC-D from three tertiary care cancer centers in Ontario, Canada (London, Sudbury, Ottawa) between June 2006 and December 2008 were included in this retrospective analysis. Data included: demographics, staging, hormone receptor status, primary prophylaxis use with growth factors, FN rate, admission to hospital and duration of hospital admission.Results: Median age of 630 women is 52 years (r: 24-77). Staging was: I (88), IIA (243), IIB (159), IIIA (94), IIIB (23), IIIC (14) and 9 unknown. A total of 474 (75.2%) were ER positive. Primary prophylaxis with growth factor support was given to 222 patients (35%) and 408 patients (65%) did not have upfront prophylaxis. Of the 222 patients who were given primary prophylaxis, 14 patients (6.3%) were diagnosed with FN. Of the 408 patients who did not receive primary prophylaxis, 120 patients (29.4%) were diagnosed with FN. All patients (n=120) diagnosed with FN received secondary prophylaxis with growth factor support. A total of 126 patients (20%) were admitted to hospital for FN. The median duration of hospital admission was 3.9 days (r: 1-65 days). The impact of risk factors, the use of filgastrim versus pegylated filgastrim on FN rates and the clinical ramifications of febrile neutropenia (ICU admissions/deaths) will be reported.Conclusions: The results of this retrospective analysis demonstrate a much higher risk of FN (29.4%) with FEC-D than has been previously reported. More complete reporting of primary prophylaxis is required. This rate of FN would warrant use of primary prophylaxis for patients prescribed FEC-D, particularly in high risk subgroups. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2087.
'Shoe Leather Therapy' Is Gaining on TB
Authors: Rebecca Voelker
Journal: JAMA (1996)

THROUGHOUT the dimly lit hallways of a Newark, NJ, housing project, a musty odor mingles with the smell of urine and cooking food. Darryl Sabu Kilgore takes it in stride as he gently raps on the door of Belinda Warren's one-room apartment. Warren is a young woman, but she moves slowly. She manages a faint smile for Kilgore, who's a regular visitor. So regular, in fact, that he follows Warren's frequent moves—four in the last 6 months alone. If he lost track of her, Warren might not take her tuberculosis (TB) medication. The result could be life-threatening multidrug-resistant TB for Warren and the risk of an outbreak in the building where she lives. "We're aggressive in our approach to getting people cured," says Kilgore, a public health representative at the University of Medicine and Dentistry of New Jersey—New Jersey Medical School's National Tuberculosis Center in Newark. <h3>Getting Results</h3> Kilgore, like
Environmental Health Indicators of Climate Change for the United States: Findings from the State Environmental Health Indicator Collaborative
Authors: Paul B. English, Amber H. Sinclair, Zev Ross, Henry Anderson, Vicki Boothe, Christine Davis, Kristie Ebi, Betsy Kagey, Kristen Malecki, Rebecca Shultz, Erin Simms
Journal: Environmental Health Perspectives (2009)

To develop public health adaptation strategies and to project the impacts of climate change on human health, indicators of vulnerability and preparedness along with accurate surveillance data on climate-sensitive health outcomes are needed. We researched and developed environmental health indicators for inputs into human health vulnerability assessments for climate change and to propose public health preventative actions.
Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans.
Authors: S D Salas, J E Bennett, K J Kwon-Chung, J R Perfect, P R Williamson
Journal: The Journal of Experimental Medicine (1996)

To assess the relationship between melanin production by Cryptococcus neoformans and virulence on a molecular basis, we asked: (a) is CNLAC1, the laccase structural gene of C. neoformans, expressed in vivo?; (b) can mouse virulence be restored to cnlac1 (Mel-) mutants by complementation with CNLAC1?; and (c) will targeted gene deletion of CNLAC1 decrease virulence for mice? Melanin is produced when cryptococcal laccase catalyzes the oxidation of certain aromatic compounds, including L-dopa, to quinones, which then polymerize to melanin. To assess CNLAC1 transcription, RNA was extracted from C. neoformans in cerebrospinal fluid of infected rabbits. Reverse transcriptase-polymerase chain reaction detected CNLAC1 transcript, indicating that laccase may be produced in the infected host. To assess the effect of CNLAC1 deletion on virulence, a Mel- mutant (10S) was obtained by disruption of the 5' end of the gene. After multiple backcrosses with a parental strain to remove unintended genetic defects introduced by the transformation process, a Mel- progeny was tested and found to be much less virulent for mice than a Mel+ progeny. Another Mel- strain (mel2), obtained from J.C. Edman (University of California at San Francisco, CA), produced CNLAC1 transcript but no detectable melanin. Characterization of this mutant revealed a base substitution in CNLAC1 that changed a histidine to tyrosine in a putative copper-binding site. When this base change was introduced into CNLAC1 by site-directed mutagenesis, it no longer transformed mel2 to Mel+, indicating the importance of this histidine in laccase activity. Complementation of a mel2-derived mutant with CNLAC1 restored the Mel+ phenotype and increased virulence. These results support the concept that the CNLAC1 gene product has a role in virulence.
282 HIGH INCIDENCE OF HEPARIN INDUCED THROMBOCYTOPENIA (HIT) IN SPLANCHNIC VEIN THROMBOSIS TREATED WITH LOW MOLECULAR WEIGHT HEPARIN (LMWH)
Authors: M. Primignani, A. Dell' Era, P.M. Fabris, R. Reati, A. Artoni, P.M. Mannucci
Journal: Journal of Hepatology (2008)
Hallucinations and nonsensory correlates of neural activity
Authors: Kenneth D. Harris
Journal: Behavioral and Brain Sciences (2004)

Behrendt &amp; Young (B&amp;Y) suggest that hallucinations occur as a result of decoupling of neuronal populations from sensory control. I propose that such a decoupling is in fact a constant feature of brain activity, even under nonpathological conditions. This position is justified by evidence from recent neurophysiological recording studies. I suggest that hallucinations arise because of a breakdown in segregation of internally and externally generated activity in a neuronal population.
Group of Artists
Authors: Thomas B. Cole
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hereditary complement (C9) deficiency associated with dermatomyositis
Authors: E. Ichikawa, J. Furuta, Y. Kawachi, S. Imakado, F. Otsuka
Journal: British Journal of Dermatology (2001)

A 28-year-old Japanese woman with hereditary complement (C9) deficiency and dermatomyositis is reported. She had a 3-year history of facial erythema and a 1-month history of progressive muscle weakness. Clinical and laboratory findings were suggestive of dermatomyositis; muscle biopsy confirmed an inflammatory myopathy. An unexpected finding, however, was the low titre of serum haemolytic complement (CH50). Treatment with prednisolone resulted in marked clinical improvement but did not affect the CH50 titre. Further investigation revealed a selective and total absence of the ninth complement component (C9), with direct DNA sequence analysis revealing a non-sense mutation at Arg95 of the C9 gene. This case demonstrates that the muscle lesions of dermatomyositis can occur in the presence of a complement defect that would prevent the formation of the C5b-9 membrane attack complex.
Chest Pain, Dyspnea, and Cor Pulmonale
Authors: Melvin E. Clouse
Journal: JAMA (1965)

Dr. Melvin E. Clouse: A 39-year-old man noted the onset of easy fatigability, dyspnea on exertion, but no orthopnea four months ago. Two months before admission he developed an upper respiratory infection with chills and fever lasting 48 hours. After this he was asymptomatic except for dyspnea on exertion until two weeks later when he experienced the acute onset of left pleuritic pain on the left side of the chest, made worse by motion and change of position; it radiated throughout the anterior portion of the chest and left shoulder. There were no chills, fever, sweats, syncope, or cyanosis. He was hospitalized with chest pain, but did not appear acutely ill. Blood pressure was 120/70 mm Hg with a paradoxical pulse of 10 mm Hg. Temperature was 98.6 F (37 C) and respirations 24 per minute. Pertinent physical findings included decreased excursion of the left hemidiaphragm without evidence of rubs