tbuckley/cabot-search huggingface dataset:
Developmental changes in the superoxide dismutase activity of human skin fibroblasts are maintained in vitro and are not caused by oxygen.
Authors: R G Allen, A K Balin
Journal: Journal of Clinical Investigation (1988)

Confluent cultures of human skin fibroblast lines established from fetal and postnatal donors were exposed to a broad range of oxygen tensions (10-600 mmHg) for 1 wk; superoxide dismutase (SOD) activity was subsequently determined. Hyperoxia increased SOD activity slightly in postnatal lines but not in fetal lines. The magnitude of the increase in postnatal lines was not significant. Fetal lines exhibit only about one-fifth the SOD activity observed in postnatal lines. The results indicate that, while development-associated changes in SOD do occur in human cells, these alterations do not result from variations in ambient oxygen tension.
Etiology of pure tricuspid regurgitation based on anular circumference and leaflet area: Analysis of 45 necropsy patients with clinical and morphologic evidence of pure tricuspid regurgitation
Authors: Bruce F. Waller, Ann T. Moriarty, John N. Eble, Diane M. Davey, Dean A. Hawley, John E. Pless
Journal: Journal of the American College of Cardiology (1986)
KLF13 sustains thymic memory-like CD8+ T cells in BALB/c mice by regulating IL-4–generating invariant natural killer T cells
Authors: Dazhi Lai, Jinfang Zhu, Tianhong Wang, Jane Hu-Li, Masaki Terabe, Jay A. Berzofsky, Carol Clayberger, Alan M. Krensky
Journal: The Journal of Experimental Medicine (2011)

"Memory-like T cells" are a subset of thymic cells that acquire effector function through the maturation process rather than interaction with specific antigen. Disruption of genes encoding T cell signaling proteins or transcription factors have provided insights into the differentiation of such cells. In this study, we show that in BALB/c, but not C57BL/6, mice, a large portion of thymic CD4(-)CD8(+) T cells exhibit a memory-like phenotype. In BALB/c mice, IL-4 secreted by invariant natural killer T (iNKT) cells is both essential and sufficient for the generation of memory-like T cells. In C57BL/6 mice, iNKT cells are less abundant, producing IL-4 that is insufficient to induce thymic memory-like CD8(+) T cells. BALB/c mice deficient in the transcription factor Kruppel-like factor (KLF) 13 have comparable numbers of iNKT cells to C57BL/6 mice and extremely low levels of thymic memory-like CD8(+) T cells. This work documents the impact of a small number of KLF13-dependent iNKT cells on the generation of memory-like CD8(+) T cells.
FACTORY VENTILATION AND INDUSTRIAL TUBERCULOSIS
Authors: C.-E. A. WINSLOW
Journal: JAMA (1925)

The first definite step toward the first hand scientific study of industrial hygiene in the United States was inspired by a problem of factory ventilation. The objectionable atmospheric conditions in a rope factory located in a suburb of Boston led to the introduction into the Massachusetts legislature by Hon. Andrew J. Peters (later mayor of the city) of a resolution calling for an investigation of the whole subject of industrial hazards by the state board of health. This was in 1904, and the brief report of ten printed pages submitted by the board in pursuance of this act was the beginning of a most significant movement. It led to a second and more exhaustive study by the Massachusetts State Board of Health in 1905, and to the employment for the first time in America of expert medical inspectors of factories in 1907; and it was the stimulus that induced me
Scleroderma associated with Raynaud's Disease and Addisonian Pigmentation
Authors: G. C. R. Harbinson
Journal: BMJ (1904)

walk.A week later he was walking fairly well with a stick, though there was still exaggerated knee-jerk.The case then passed out of my hands.That these cases were both hysteria I have no doubt.As complete recover-y of Case ii had not taken place when I parted from him, I cannot say for certain that it was purely hysterical.It may be thought that there was a malingering element in both the cases, for both men expressed their wish to be invalided, thus revealing a sufficient motive; but that Case i, however, could have gone on to bedsores without self- mesmerizing agency is unlikely.
Arsenic-Induced Atypical Ventricular Tachycardia
Authors: Steven Goldsmith, Arthur H. L. From
Journal: New England Journal of Medicine (1980)

ARSENIC intoxication can lead to severe multi-system illness, the cardiac manifestations of which have been infrequently stressed in the literature.1 , 2 To our knowledge, associated dysrhythmia has been described only once previously.3 We report a case of severe arsenic poisoning complicated by atypical, life-threatening ventricular tachycardia. The early recognition of atypical ventricular tachycardia is crucial since its correct treatment differs markedly from that used for the usual types of ventricular tachycardia.Case ReportThe patient, a 57-year-old man, was admitted to the Minneapolis Veterans Administration Medical Center; he reported severe abdominal pain, nausea, vomiting, diarrhea, bilateral hearing deficit, and decreased sensation . . .
Drug induced lymphocytic colitis.
Authors: L Beaugerie, J Luboinski, N Brousse, J Cosnes, F P Chatelet, J P Gendre, Y Le Quintrec
Journal: Gut (1994)

Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient where the immunopathological features of mucosal immune cell activation were induced by drug rechallenge. It is concluded that lymphocytic colitis may be drug induced, secondary to a chronic activation of the mucosal immune system by one or several components of the drug.
Immunoaugmentative Therapy: Assessing an Untested Therapy
Authors: Stuart L. Nightingale
Journal: JAMA (1988)

The article on immunoaugmentative therapy (IAT) in this issue of<i>JAMA</i><sup>1</sup>is an important and timely one. Immunoaugmentative therapy has been widely promoted for well over a decade, and despite the lack of any genuine scientific study
Movement Away From Phenolphthalein in Laxatives—Reply
Authors: Ronald G. Evens
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improvement of liver function parameters in patients with type 2 diabetes treated with thiazolidinediones
Authors: Masaya Ono, Hiroshi Ikegami, Tomomi Fujisawa, Koji Nojima, Yumiko Kawabata, Masanori Nishino, Hidenori Taniguchi, Michiko Itoi-Babaya, Naru Babaya, Kaori Inoue, Toshio Ogihara
Journal: Metabolism (2005)
Spontaneous course of ST-segment elevation in acute anterior myocardial infarction.
Authors: R Essen, W Merx, S Effert
Journal: Circulation (1979)

The spontaneous course of ST-segment elevation (sigmaST) in 24 patients with acute anterior myocardial infarction (AMI) was studied by precordial ST-segment mapping, which was recorded at 2-hour intervals during the first 48 hours after admission. Change of sigmaST between two registrations was expressed as mV/hr, and was compared with clinical and hemodynamic parameters, course of MB-CK curve, calculated infarct mass and arrhythmias. After an initial rapid increase, there was a decrease of sigmaST, which reaches a plateau-like curve approximately 12 hours after the onset of chest pain. A second new increase of sigmaST exceeding a value of 0.6 mV/hr correlates well with extension of necrosis, verified by re-elevation of MB-CK. During the first 2 days, extension of necrosis could be detected in 50% of our patients. As new ischemic episodes and extension of necrosis in AMI occur frequently and are promptly indicated by an increase of sigmaST, the physician should, while monitoring therapeutic interventions, concentrate on such a second increase rather than on a decrease of sigmaST (which may occur spontaneously), as has been suggested in most previous reports.
Abstract 81: Deregulated expression of HDAC9 in B cells leads to the development of lymphoproliferative disease and lymphoma
Authors: Veronica S. Gil
Journal: Cancer Research (2014)

Abstract Aberrant epigenetics leading to changes in chromatin structure and patterns of gene expression is an important factor in cancer pathogenesis. Histone Deacetylase 9 (HDAC9) is a class IIa chromatin-modifying enzyme that, within the haematopoietic system, is preferentially expressed in the B-cell lineage. Furthermore, HDAC9 expression is deregulated in B-lymphoid malignancies. To examine the role of HDAC9 in malignant B-cell transformation, we generated an in vivo mouse model that constitutively expresses human HDAC9 from early stages of B-cell development under the control of the immunoglobulin heavy chain (IgH) enhancer (Eµ). In this study, we demonstrate that from an average of six months of age, Eµ-HDAC9 transgenic mice displayed splenomegaly and immunophenotypic features that resemble lymphoproliferative disease (LPD) in spleen. Later on in life, up to twenty-three months of age, 24% (19 out of 78) of Eµ-HDAC9 mice developed mature B-cell neoplasms such as splenic marginal zone lymphoma (SMZL) and aggressive diffuse large B-cell lymphoma (DLBCL) that could represent a progression stage of the observed lymphoproliferative disease (LPD) and monoclonal B-cell lymphocytosis (MBL). In contrast, a low background incidence of these malignancies was observed in control mice, 2% (1 out of 46) (p = 0.0008). The molecular pathogenesis of the Eµ-HDAC9 B-cell tumors seems to involve activation-deactivation of the BCL6-p53 axis by HDAC9 influenced deacetylation thus affecting DNA repair and cell cyle progression in germinal centre (GC) during immune response. Consistently, ZFN-mediated HDAC9-knockout results in cell cycle changes leading to strong inhibition of cell growth in vitro. In summary, aberrant expression of HDAC9 leads to the development of lymphoproliferative disorders, including GC and post-GC lymphomas, demonstrating an oncogenic role for HDAC9 in B-cells and highlighting its importance as a therapeutic target. Citation Format: Veronica S. Gil. Deregulated expression of HDAC9 in B cells leads to the development of lymphoproliferative disease and lymphoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 81. doi:10.1158/1538-7445.AM2014-81
PERITONEAL PSEUDO-MYXOMA ORIGINATING FROM THE VERMIFORM APPENDIX
Authors: W. Trotter
Journal: BMJ (1910)

mortem room.Many of the described examples have shown no local malignancy, displacing and not infiltrating, and remaining very definitely encapsuled.This has given -rise to the statement that absence of haematuria is charac-,teristic of this growth.This statement is, however, much too absolute.Authorities whose records cannot be ques.'tioned-Israel, for example-have described series of such eoases in many of which haematuria was a prominent eymptom.It appears clear that the renal tumours arising in adrenal "rests" do not belong exclusively either to the ,group of simple tumours or to that of malignant tumours.Some undoubtedly are simple clinically and "typical" 'histologically, others malignant clinically and " atypical" iistologically.
Functionalized carbon nanotubes as immunomodulator systems
Authors: Mario Pescatori, Davide Bedognetti, Enrica Venturelli, Cécilia Ménard-Moyon, Camilla Bernardini, Elena Muresu, Andrea Piana, Giorgio Maida, Roberto Manetti, Francesco Sgarrella, Alberto Bianco, Lucia Gemma Delogu
Journal: Biomaterials (2013)
Wolff's Headache and Other Head Pain
Authors: Dhirendra S. Bana
Journal: JAMA (1994)

Originally published in 1948,<i>Wolff's Headache and Other Head Pain</i>has been the dominant text on headache for nearly half a century. Printing of this sixth edition gives testimony to its long-term success as a leading source of instruction for generations of physicians in effectively dealing with the complex problems of headache management. This new edition once again provides the reader with current literature on headache and headache-related problems. Although this edition describes headache according to The International Headache Society Classification of Headaches (1988), the overall format of the book remains unchanged from the fifth edition, which was based on the classification of the International Association for the Study of Pain (1986). Readers familiar with that edition will recognize many of the authors and their respective topics. In most cases, original work that remains relevant today has been complemented with updates. For example, the etiology of cluster headache remains elusive,
Beneficial effects of adrenergic blockade in patients with subarachnoid haemorrhage.
Authors: P Walter, G Neil-Dwyer, J M Cruickshank
Journal: BMJ (1982)

A total of 148 patients presenting within 48 hours of subarachnoid haemorrhage were assigned at random to receive standard management only or standard management and treatment with the adrenergic-blocking agents propranolol and phentolamine (or propranolol alone) for three weeks. One hundred and thirty-four patients completed the study. Assessment at four weeks showed a strong trend for less neurological deficit in the treated group, almost statistically significant (p=0.053) in the women. During the first month the treated group suffered fewer episodes of clinical deterioration consistent with cerebral arterial spasm: thus more treated patients underwent operation and those who did had a better outcome (p=0.030). At one year fewer were dead or disabled (unable to work) in the treated group; a significant difference for women (p=0.030). Possible mechanisms for these actions may include a reduction in pulmonary oedema, prevention of myocardial infarcts, a reduction in plasma renin activity, nd a reduction in cerebral oxygen requirements. It is concluded that early adrenergic blockade benefits patients (particularly women) with subarachnoid haemorrhage for up to one year in terms of lesser neurological deficit. Beta-blocker rather than alpha-blockade appears to be the useful component. A randomised, blind extension of the present study using long-acting propranolol and placebo has shown a significant (p=0.026) decrease in deaths and significantly (p=0.003) fewer poor results in the treatment group.
4 Inhibition of VEGF receptor-2 (VEGFR-2) signaling prevents portal-systemic collateral (PSC) vessel formation in rats with portal hypertension (PH)
Authors: M. Fernandez, M. Mejias, B. Angermayr, J.C. Garcia-Pagan, J. Rodes, J. Bosch
Journal: Journal of Hepatology (2004)
Lack of effect of anti-hypertensive treatment with felodipine on cardiovascular structure of young spontaneously hypertensive rats
Authors: N C B NYBORG, M J MULVANY
Journal: Cardiovascular Research (1985)

Felodipine (4(2,3-dichlorophenyl)-1,4-dihydro-2, 6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonyl pyridine)), a selective vasodilating anti-hypertensive drug, was used in the treatment of spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto rats (WKYs) from age 6 to 14 weeks, ie during the time of high blood pressure development in SHRs. The effect of treatment on heart weight and on mesenteric resistance vessels (i.d. ca 170 microns) characteristics was investigated. In a first study, two oral doses of felodipine were added to the diet of SHRs, in concentrations of either 0.5 or 1.5 mg X g-1 rat food. Both treatments lowered mean arterial pressure by about 19% (p less than 0.001). In a second study, the lower dose of felodipine (0.5 mg . g-1 rat food) was therefore used to treat both SHRs and WKYs. Treatment did not interfere with weight or food intake of either SHRs or WKYs but increased average weekly water intake significantly. In neither strain was the pulse rate or, surprisingly, heart/body weight ratio affected by treatment. Furthermore, mesenteric resistance vessel morphology and mechanics were not affected by the blood pressure reduction. The noradrenaline and calcium sensitivity of mesenteric resistance vessels from treated rats was greater (p less than 0.001) than those from control rats. These findings indicate that blood pressure reduction with felodipine does not affect cardiovascular structure in young SHRs.
Breast Cancer of an Accessory Nipple
Authors: Leah S Gendler, Kathie-Ann Joseph
Journal: New England Journal of Medicine (2005)

A 42-year-old woman presented to the breast clinic with a mass posterior to an accessory nipple (arrow) that had been progressively enlarging over the past year. On physical examination, the patient had an irregular, hard mass, 3 cm by 4 cm, overlying the chest wall. The mass was inferior to the right inframammary fold and directly posterior to the accessory nipple. There were focal erythematous skin changes, suggesting local skin involvement. The patient also had a palpable right axillary lymph node. A punch biopsy of the mass was performed, which revealed a poorly differentiated adenocarcinoma, consistent with invasive ductal carcinoma . . .
130 A MULTIVALENT ADENOVIRUS-BASED IMMUNOTHERAPEUTIC FOR TREATMENT OF CHRONIC HEPATITIS B INDUCES BROAD, ROBUST AND POLYFUNCTIONAL T CELLS IN NAIVE AND HBV TOLERANT MICE
Authors: P. Martin, C. Dubois, E. Jacquier, A. Evlachev, H. Boukhebza, S. Dion, M. Mancini-Bourgine, O. Godon, A. Findeli, Y. Schlesinger, R. Brandely, J.-B. Marchand, T. Menguy, N. Silvestre, R. Schirmbeck, M.-L. Michel, G. Inchauspé
Journal: Journal of Hepatology (2013)
Alarmin S100A8 causes severe cartilage damage in antigen-induced arthritis through TLR4 activation and upregulation of Fc RI and Fc RIV
Authors: P. L. E. M. van Lent, L. Grevers, R. Schelbergen, A. Blom, A. Sloetjes, T. Vogl, J. Roth, W. B. van den Berg
Journal: Annals of the Rheumatic Diseases (2010)

The ‘alarmins’ S100 A8 and A9 have been described not only as markers for inflammation but may also be involved in induction of erosive cartilage destruction.1 S100A8 represents the active form whereas S100A9 binds to S100A8, protecting the protein from degradation. The aim of the study is to identify the mechanisms of S100 involvement in severe cartilage destruction during antigen-induced arthritis.

Antigen-induced arthritis (AIA) was induced in knee joints of S100A8/A9-/- mice (myeloid cells also …
Human Immunodeficiency Virus (HIV) Infection and the Kidney
Authors: Richard J. Glassock
Journal: Annals of Internal Medicine (1990)

Since the first report on the acquired immunodeficiency syndrome (AIDS) in 1981, organ involvement of AIDS has increased. We discuss the effect of human immunodeficiency virus (HIV) infection, the causative agent of AIDS, on the field of nephrology. Hyponatremia, the commonest fluid and electrolyte abnormality, is caused by various pathophysiologic mechanisms, including adrenal insufficiency. The renal parenchymal complications are diverse, but a new entity, HIV-associated nephropathy, is becoming recognized because of its characteristic clinical and pathologic features, including the fact that it causes irreversible renal failure. HIV infection in patients with end-stage renal failure, both before and after initiation of maintenance dialysis, is a significant problem. The present methods of preventing spread of virus in dialysis units seem successful. Few patients who are infected with HIV or who have AIDS have had renal transplantation, although unsuspected viral infection of cadaveric organs remains a concern.
WHO warns of a polio epidemic in Africa
Authors: Fiona Fleck
Journal: BMJ (2004)

Africa could be on the brink of a major poliomyelitis epidemic after a child in Sudan's crisis ridden Dafur region was found to have been paralysed by the disease last month, World Health Organization officials warned on Tuesday.

It was the first confirmed case of polio, which mainly affects children under the age of five, …
Electroencephalographic Changes in Children with Migraine
Authors: Dennis Whitehouse, John A. Pappas, Pablo H. Escala, Samuel Livingston
Journal: New England Journal of Medicine (1967)

THE concept of migraine as a seizure manifestation, based on the clinical picture of a paroxysmal disorder, often with a preceding aura, followed by various clinical manifestations, including neurologic signs and symptoms and a "postictal" phase of sleepiness, has considerable antiquity. The first published suggestion of a linkage between migraine and epilepsy is probably that of Liveing.1 Gowers2 was the first to use the term "Borderland of Epilepsy" to include both migraine and certain types of vertigo. Hughlings Jackson3 also had clearly considered such a relation when he demonstrated a case illustrating "the relationship between certain cases of migraine and . . .
Efficacy Of 300IR 5-Grass Pollen Sublingual Tablets In The Treatment Of Rhinitis Symptoms In Patients With Grass Pollen-Induced Allergic Rhinoconjunctivitis
Authors: Claus Bachert, Alain Didier, Laurence Ambroisine, Kathy Abiteboul, Robert K. Zeldin
Journal: Journal of Allergy and Clinical Immunology (2014)
Prospective cohort study of acute pyelonephritis in adults: Safety of triage towards home based oral antimicrobial treatment
Authors: C. van Nieuwkoop, J.W. van't Wout, I.C. Spelt, M. Becker, E.J. Kuijper, J.W. Blom, W.J.J. Assendelft, J.T. van Dissel
Journal: Journal of Infection (2009)