tbuckley/cabot-search huggingface dataset:
Long-term follow-up of the Hancock bioprosthetic heart valve: a 6-year review.
Authors: L H Cohen, J K Koster, R B Mee, J J Collins
Journal: Circulation (1979)

Clinical experience with the Hancock porcine bioprosthetic heart valve was reviewed in 467 patients (254 men and 213 women, 18--84 years old, average, 56 years) who received 528 valves from January, 1972, to January, 1978. Associated procedures, including coronary bypass graft, ascending aortic aneurysm, and valvuloplasty were done in 102 of the 467 patients (22%). The overall operative mortality was 25/467 (5.6%), 12/226 (5.3%) for aortic valve replacement (AVR), 11/183 (6%) for mitral valve replacement (MVR), and 2/58 (3.4%) for multiple valve replacement. The first 323 patients with a minimum follow-up of 16 months (16--75 months, average 33 months) were analyzed for survival and thromboemboli. Actuarial survival at 66--75 months was 75.7% for AVR, 79% for MVR, and 75.8% for multiple valve replacement. Emboli per 100 patient-years was 0.55 for AVR (no anticoagulants), 3.9 for MVR, and 4.8 for multiple valve replacement (anticoagulants for atrial fibrillation patients only); emboli occurred only in patients with atrial fibrillation. There were seven of 528 primary dysfunctional valves (1.3%): calcification in two, tissue failure in two, and fibrosis in three. A hemodynamic study of four patients with a 21 mm Hancock Modified Orifice aortic valve prosthesis showed improved orifice areas (greater than 1.3 cm2) over the standard aortic valve. The Hancock porcine xenograft bioprosthetic heart valve has been a durable heart valve in excess of 6 years and has a low associated incidence of thromboemboli in patients off anticoagulants except in those with chronic atrial fibrillation.
THE INCORPORATION OF COPPER INTO CERULOPLASMIN IN VIVO: STUDIES WITH COPPER64 AND COPPER67*
Authors: Irmin Sternlieb, Anatol G. Morell, Walter D. Tucker, Margaret W. Greene, I. Herbert Scheinberg
Journal: Journal of Clinical Investigation (1961)

The hypothesis that ceruloplasmin exchanges its copper for ionic copper in vivo was tested, by means of ceruloplasmin labeled with copper-64 and copper- 67, in two patients with Wilson's disease and in two control subjects. No indication of exchange was found in any of three different experiments. It appears that copper is incorporated into the ceruloplasmin molecule in vivo only at the time of synthesis of the protein and not through exchange. A corollary of these results is that copper is a lifelong label of a ceruloplasmin molecule so that radioactive copper may be used for the determination of the turnover of ceruloplasmin and ceruloplasmin copper. The amount of copper incorporated daily into ceruloplasmin in a control subject corresponds closely to the amount of copper absorbed from the dietary intake. (auth)
Multistage tattoo removal using carbon dioxide laser
Authors: P.J. August, R. Birchenough, E. Godfrey, R. Williamson, M. Gunningham-Hill
Journal: British Journal of Dermatology (1985)

Journal Article Multistage tattoo removal using carbon dioxide laser Get access P.J. August, P.J. August The Skin Hospital, Manchester M3 and The Northern Laser Clinic, Manchester M3 Search for other works by this author on: Oxford Academic Google Scholar R. Birchenough, R. Birchenough The Skin Hospital, Manchester M3 and The Northern Laser Clinic, Manchester M3 Search for other works by this author on: Oxford Academic Google Scholar E. Godfrey, E. Godfrey The Skin Hospital, Manchester M3 and The Northern Laser Clinic, Manchester M3 Search for other works by this author on: Oxford Academic Google Scholar R. Williamson, R. Williamson The Skin Hospital, Manchester M3 and The Northern Laser Clinic, Manchester M3 Search for other works by this author on: Oxford Academic Google Scholar M. Gunningham‐Hill M. Gunningham‐Hill The Skin Hospital, Manchester M3 and The Northern Laser Clinic, Manchester M3 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 29–30, https://doi.org/10.1111/j.1365-2133.1985.tb12989.x Published: 01 July 1985
A Jewish Response to the Vatican's New Bioethical Guidelines
Authors: Ari Z. Zivotofsky, Alan Jotkowitz
Journal: The American Journal of Bioethics (2009)

The Vatican recently published directives (Dignitas Personae) regarding "beginning of life" issues that explain the Catholic Church's position regarding new technologies in this area. We think that it is important to develop a response that presents the traditional Orthodox Jewish position on these same issues in order to present an alternative, parallel system. There are many points of commonality between the Vatican document and traditional Jewish thought as well as several important issues where there is a divergence of opinion. The latter include the status of the zygote as produced during in vitro fertilization (IVF), the acceptable of procreation in a method other than through the conjugal act, and the permissibility of deriving benefit from the products of an illicit act. These points of agreement and disagreement are discussed in detail in this article.
Care and cost savings at the end of life
Authors: B. Madden
Journal: JAMA (1996)

To the Editor.  —I read with interest the article on cost savings at the end of life by Dr Emanuel 1 because of a personal experience. My father had chosen 2 years ago to die with the support of a hospice program.  I suggest to the author that the point at which to begin comparing the costs of hospice and nonhospice care is when it is necessary to make a decision for intervention in order to sustain life. Care that has as its primary purpose to sustain life, rather than the primary purpose of providing comfort and relief from pain and discomfort (even if it prolongs life), would be the criterion for exclusion from the hospice group.  I take issue with the author's suggestion that the indirect cost of a family member's care should be considered in the cost of hospice care. I do not believe that it is factored
EU health minister renews calls for specialist disease control centre
Authors: R. Watson
Journal: BMJ (2003)

The SARS epidemic was a wake-up call alerting European Union governments to the need for a special centre for disease prevention and control, David Byrne, EU public health commissioner, has warned.

Mr Byrne has, for some time, been arguing the need for could provide a centre which could coordinate an effective response to an epidemic. But the outbreak of severe acute respiratory syndrome (SARS) earlier this year has given the idea added urgency, he believes.

“In the modern world, infectious diseases can spread across the globe in a matter of days or even hours, and when it comes …
CHANGES IN RIGHT VENTRICULAR STRUCTURE AND PERFORMANCE IN MORBIDLY OBESE PATIENTS AFTER BARIATRIC SURGERY: A CMR STUDY
Authors: María Luaces, Victoria Cachofeiro, Sandra Secades Gonzalez, Vieira Catarina, Mariana Paiva, Jorge Cabezudo Pedrazo, Leopoldo Pérez de Isla
Journal: Journal of the American College of Cardiology (2013)
Sharp rise in deaths in South Africa is largely due to AIDS
Authors: Pat Sidley
Journal: BMJ (2005)

New statistics from the South African government show a 57% increase in the number of deaths between 1997 and 2002. Government statisticians believe that a large proportion of the increase is attributable to AIDS.

The figures have been produced by the country's statistician general of statistics, Pali Lehohla, whose own job is said to be under threat over a series of blunders in other statistical reports. Her position is thought to have been weakened further because this latest report is likely to embarrass President Thabo Mbeki, who has been ambivalent about dealing with the HIV and AIDS epidemic.

In people over 15 years old deaths increased by 62% over the …
Very severe aplastic anemia following resection of lymphocytic thymoma: Effectiveness of antilymphocyte globulin, cyclosporin A, and granulocyte-colony stimulating factor
Authors: Günçağ Dinçol, Bülent Saka, Melih Aktan, Meliha Nalçacı, Hüseyin Keskin, Şükrü Palanduz, Şükrü Öztürk, Koray Dinçol
Journal: American Journal of Hematology (2000)

To the Editor: Painful crisis is the most common complication in patients with sickle cell disease (SCD), while central retinal artery occlusion (RAO)
Book Review Clinical Practice of Transfusion Medicine Third edition. Edited by Lawrence D. Petz, Scott N. Swisher, Steven Kleinman, Richard K. Spence, and Ronald G. Strauss. 1115 pp. New York, Churchill Livingstone, 1996. $149.95. 0-443-08981-7
Authors: Eleanor S. Pollak, Leigh C. Jefferies
Journal: New England Journal of Medicine (1996)
Abstract 2623: ST3595, a new histone deacetylase (HDAC) inhibitor endowed with a peculiar mechanism of action
Authors: Claudio Pisano, Loredana Vesci, Ferdinando M. Milazzo, Mario B. Guglielmi, Marcella Barbarino, Rosanna Foderà, Valentina Zuco, Franco Zunino
Journal: Cancer Research (2011)

Abstract The novel hydroxamic acid-based compound ST3595, was identified within an in vitro screening for its inhibitory activity on histone deacetylase's (HDAC's) (Pisano C. et al., Clin Cancer Res 2010, 16 (15): 3944-53; Dalla Valle S et al., Eur J Med Chem 2009, 44 (5): 1900-12). With aim to define its antitumor potential, we investigated the in vivo activity of ST3595 in a variety of tumor models. In addition, we performed a comparative study of ST3595 and vorinostat (SAHA) to better understand the cellular/molecular basis of the antiproliferative activity. In in vivo experiments, ST3595, delivered orally or i.p. at well-tolerated doses (100 mg/kg) induced a significant tumor growth inhibition (ranging from 57 to 87%) in a variety of human tumor xenografts (H460 non-small cell lung, HCT116 colon and A2780 ovarian carcinoma). In in vitro studies, ST3595 exhibited arrest of H460 cells (wt p53) in S phase associated with a large extent of apoptosis. Under conditions producing comparable antiproliferative effects, treatment with vorinostat resulted in a G2/M arrest with a marginal induction of apoptosis. In HT29 cells (mutant p53) ST3595 caused arrest in S and G2/M phases with apoptosis induction, whereas vorinostat induced G1 accumulation without evidence of apoptosis, thus suggesting only antiproliferative effects. To explore the basis of the different cellular effects, we investigated the modulation of various factors implicated in DNA damage response and repair, cell cycle control and regulation of apoptosis. In H460 cells, we found that, in contrast to vorinostat, ST3595 was an effective inducer of p53 acetylation, supporting a role of this p53 modification in the proapoptotic activity of ST3595. In addition, in contrast to vorinostat, ST3595 strongly affected the expression of critical proteins involved in cell cycle control and DNA damage response. In particular, ST3595 induced activation and phosphorylation of H2AX, and of the checkpoint kinases chk1 and chk2, thus supporting an interference of the HDAC inhibitor in the processes controlling DNA integrity. In the light of the use of broad-specificity HDAC inhibitors in cancer therapy and in combination with other antitumor agents, the ability of ST3595 to modulate DNA damage response and it proapoptotic efficacy may have relevant implications in enhancing antitumor activity of well-established cytotoxic agents. Preclinical studies of ST3595 with genotoxic agents support this interpretation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2623. doi:10.1158/1538-7445.AM2011-2623
GMC still seen as "doctors' club" despite reforms
Authors: C. White
Journal: BMJ (2003)

The regulatory body for UK doctors, the General Medical Council, has done much to modernise itself and implement reform, but it is still seen as something of a “doctors' club” and is overly bureaucratic, the results of a small survey show.

The survey was carried out by independent consultants for the GMC in a bid to find out how the council is currently viewed by doctors, patients, government, and other bodies.

The results, which are based on detailed interviews with 37 people, show that the respondents felt …
What Matters Magnesium?-Reply
Authors: Kenneth W. Ryder
Journal: JAMA (1990)

<h3>In Reply.—</h3> We thank Drs Gayed, Roberts, and Brett for their interest in our report. Our study was designed to assess the effectiveness of physician-initiated requests vs routine determination in identifying patients with abnormal serum magnesium concentrations. Clinical correlation, although desirable, was beyond the scope of this study. It is important to note that clinical perturbation in serum magnesium can have serious implications in patient management. Refractory hypotension, respiratory arrest, and mental obtundation progressing to coma have been associated with hypermagnesemia. Hypomagnesemia can result in neurological symptoms and serious cardiac arrhythmias. How many hospitalized patients today suffer from the consequences of clinically unrecognized hypermagnesemia and hypomagnesemia remains to be determined. In our opinion, there is an analogy between serum potassium and magnesium. Most clinicians do not wait for hypokalemia to become symptomatic before treating. To wait until magnesium depletion becomes symptomatic before treating may not be in the best
ISOLATION AND IDENTIFICATION BY SEQUENCE ANALYSIS OF EXPERIMENTALLY INDUCED GUINEA PIG AMYLOID FIBRILS
Authors: Martha Skinner, Edgar S. Cathcart, Alan S. Cohen, Merrill D. Benson
Journal: The Journal of Experimental Medicine (1974)

Amyloidosis was produced experimentally in guinea pigs by multiple casein injections. Amyloid fibrils were isolated and fractionated and a protein obtained that had an amino acid composition comparable with A protein, a unique nonimmunoglobulin constituent of secondary amyloid deposits. N-terminal sequence analysis demonstrated a sequence homologous with that of A proteins from human and monkey preparations but preceded by a 5-residue peptide which had an N-terminal histidine. A definite species specificity in A protein from human and guinea pig was identified on immunologic analysis.
Cell Cycle and Cell Migration
Authors: Manfred Boehm, Elizabeth G. Nabel
Journal: Circulation (2001)

ormation of a healed arterial wound is a landmark event during the repair of vascular lesions.Adult coronary, peripheral, and cerebral arteries are exposed to multiple stresses, including mechanical trauma, endothelial denudation, damage to intimal and medial smooth muscle, abnormal shear stresses, and oxidation of LDL by macrophages, and they must undergo repair.This wound repair process, like in many other organs, requires that a complex network of molecular signals be regulated within the cytoplasm and nucleus of an endothelial or smooth muscle cell.The cell cycle is a key regulator of these signals and has direct effects on multiple cell processes, including cell proliferation, DNA repair, apoptosis, and cell migration.
Randomized Controlled Trial of Single-Agent Paclitaxel Versus Cyclophosphamide, Doxorubicin, and Cisplatin in Patients With Recurrent Ovarian Cancer Who Responded to First-Line Platinum-Based Regimens
Authors: M. G. Cantù, A. Buda, G. Parma, R. Rossi, I. Floriani, C. Bonazzi, T. Dell'Anna, Valter Torri, N. Colombo
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To assess the activity, efficacy, and tolerability of single-agent paclitaxel and a platinum-containing regimen in previously treated patients with recurrent ovarian cancer. PATIENTS AND METHODS: Patients who achieved complete remission with platinum-based regimens and whose disease recurred after a progression-free interval of more than 12 months were included in the study. Every 21 days, patients received paclitaxel 175 mg/m2 intravenously (IV) over 3 hours or cyclophosphamide 500 mg/m2, doxorubicin 50 mg/m2, and cisplatin 50 mg/m2 (CAP) IV. RESULTS: Between June 1992 and May 1995, 97 consecutive patients with assessable or measurable disease were randomized to paclitaxel (n = 50) or CAP (n = 47). The median number of cycles on each arm was six. Toxicities included grade 3/4 leukopenia (4% for paclitaxel v 34% for CAP), grade 3/4 neutropenia (13% v 36%), grade 1/2 myalgia (19% v 4%), allergic reactions (15% v 2%), and grade 2/3 nausea and vomiting (17% v 51%). Complete responses were achieved i...
P1-02-07: Epithelial-Mesenchymal Transition Correlated with Serum Cytokine Profiling in Breast Cancer Patients.
Authors: A Giordano, EN Cohen, S Anfossi, H Gao, B-N Lee, M Mego, T Sanda, V Valero, RH Alvarez, M Cristofanilli, S De Placido, GN Hortobagyi, W Woodward, NT Ueno, JM Reuben
Journal: Cancer Research (2011)

Abstract Background: Inflammation contributes to the increased invasiveness and poor prognosis in breast cancer (BC) patients. Specifically, the expression of the proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα) and interleukin-1 (IL-1) have all been linked to increased invasiveness and poor prognosis. Interestingly, the increased invasiveness was associated with an increase in the acquisition of markers of epithelial-mesenchymal transition (EMT). Therefore, we determined whether the levels of circulating proinflammatory cytokines (IL-1, IL-6, TNFα) and antiinflammatory cytokines (IL10) were correlated with the induction of EMT transcription factors (TFs), Snail1, Zeb1, Twist1, in breast cancer patients. Materials and Methods: From two laboratory-based ongoing studies at the MD Anderson Cancer Center, 41 BC patients were assessed for EMT-TFs in circulating CD45-ve cells (EMT-CTCs) and for serum proinflammatory cytokines before starting any treatment. 32 of 41 patients assessed for EMT had metastatic BC. EMT-CTCs were detected by qRT-PCR for the EMT-TFs Snail1, Zeb1 and Twist1 (Mego 2011; PMID 21387303) and serum cytokines were measured by Luminex bead array assay (MILLIPLEX™ MAP Human Cytokine/Chemokine Panel). Cytokine serum concentrations were compared with the median cytokine levels of healthy donors (HD). We examined the association of serum cytokines above the median HD levels and the presence of EMT-CTCs by non-parametric Mann-Whitney test with a statistical significance for p&amp;lt;.05. Results: Of the 41 patients assessed for both serum cytokines and EMT-CTCs, 14 (34%) were positive for at least one EMT-TF, including 3 of 9 (33%) patients with no-metastatic BC and 11 of 32 (34%) patients with metastatic BC. We found that serum levels of IL1a, IL2, TGFα, and TNFβ in patients that were above the median levels of HD sera were higher in patients with EMT-CTCs in the blood (higher IL1a concentration in patients with over expression of Snail1, Zeb1, and Twist1; IL2 with Zeb1; TGFα with Snail1; TNFβ with Zeb1, and Twist1). Further, the higher ratio of proinflammatory/anti-inflammatory cytokines, was associated with the presence of at least one EMT-TF, e.g., IL8/IL10 (p=.005) and TNFα/IL10 (p=.037). Discussion: Patients with proinflammatory cytokine (IL1a, IL2, TGFα, and TNFβ) levels above the median levels of HD or who had a predominantly proinflammatory cytokine profile were more likely to have at least one EMT-TF in their blood. These data are consistent with the hypothesis that proinflammatory cytokines promote EMT, which may be involved in tumor aggressiveness and disease progression. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-02-07.
Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry.
Authors: G G Pietra, W D Edwards, J M Kay, S Rich, J Kernis, B Schloo, S M Ayres, E H Bergofsky, B H Brundage, K M Detre
Journal: Circulation (1989)

Qualitative and quantitative studies were performed on pulmonary blood vessels in lung tissue obtained by biopsy, pneumonectomy, or autopsy from 58 patients in the Registry of Primary Pulmonary Hypertension sponsored by the Heart, Lung, and Blood Institute of the National Institutes of Health. In 49 patients (84%), the hypertensive vascular disease involved predominantly or exclusively muscular pulmonary arteries and arterioles. In each of these 49 patients, pulmonary artery medial hypertrophy was observed, and in 48 patients, it was also associated with intimal or luminal lesions. On the basis of the predominant histopathologic features, 25 of the 48 patients were classified as having pulmonary arteriopathy with plexiform lesions characterized by a combination of concentric laminar intimal fibrosis, eccentric intimal fibrosis, and plexiform lesions; in nine of these 25, recanalized thrombi were also present. Pulmonary arteriopathy with thrombotic lesions, defined by the presence of both eccentric intimal fibrosis and recanalized thrombi but without plexiform lesions, was observed in 19 patients. Intimal fibrosis, either concentric or eccentric, without plexiform or thrombotic lesions was found in four patients. Among the remaining nine patients in the Registry, pulmonary veno-occlusive disease was present in seven and chronic pulmonary venous hypertension in one. Pulmonary blood vessels were microscopically normal in a lung biopsy specimen from another patient. In general, patients with plexiform lesions and those with veno-occlusive disease had a much poorer prognosis than patients with thrombotic lesions. The present study shows the existence of several distinct histopathologic patterns of pulmonary vascular disease in individuals with primary pulmonary hypertension diagnosed by standardized clinical and laboratory criteria.
Half Empty, Half Full: What We Know About Low Birth Weight Among Blacks
Authors: Wendy Baldwin
Journal: JAMA (1986)

In 1984, Secretary of Health and Human Services Margaret Heckler appointed a task force on Black and Minority Health under the direction of Thomas E. Malone, PhD, deputy director of the National Institutes of Health. Concerned by the disparity between the health of minority Americans and that of the majority population—despite improving health for all— Secretary Heckler called for a study of the sources of the variations in health and the roles for her department in accelerating improvements in the health status of minorities. A review of the sources of the disparity showed that 80% of the excess mortality experienced by black Americans was accounted for by six categories: cancer, diabetes, cardiovascular disease, violence, substance abuse, and infant mortality. For each of these areas, a subcommittee was formed to assess the state of knowledge and make recommendations. The infant mortality/low-birth-weight subcommittee commissioned papers and reviewed current knowledge on these topics,