tbuckley/cabot-search huggingface dataset:
Acute Benign Pericarditis Associated with Coxsackie Virus Group B, Type 5
Authors: Selig B. Weinstein
Journal: New England Journal of Medicine (1957)

THIS paper presents a case of acute benign pericarditis associated with Coxsackie virus Group B, Type 5, infection. The clinical history, along with the laboratory findings, is noted, and the etiologic relation of the virus to acute benign pericarditis is discussed.Case ReportA 25-year-old man was in good health until 6 weeks before admission, when pain in the anterior aspect of the chest, aggravated by respiration, fever and shortness of breath intensified in the reclining position, suddenly developed. The maximum temperature was 103°F. He was hospitalized elsewhere for 4 days with a diagnosis of pleurisy. Upon discharge he was . . .
Information systems for general practitioners for quality assessment: III. Suggested new prescribing profile.
Authors: R C Fraser, J T Gosling
Journal: BMJ (1985)

The information that is supplied to general practitioners by the Prescription Pricing Authority and family practitioner committees has severe limitations if used for self audit of prescribing. We studied the demand for and the extent to which general practitioners would collaborate in developing a system for providing more pertinent information about patterns of personal and practice prescribing. One hundred and eighty two doctors (36% of respondents to a questionnaire) who wished to learn more about their repeat prescribing were invited to help to generate this information and to create profiles of their personal prescribing rates based on a denominator of doctor-patient contacts. Nearly all of them translated intention into participation and also recruited 28 more doctors, since all partners in a practice had to take part. Overall, 202 doctors (40%) took part, 83% of whom participated in the combined study of repeat prescribing and rate of prescribing and 17% in the repeat prescribing exercise only. The examples of the new profiles that are provided show a more accurate representation of personal and practice prescribing patterns, differentiate between face to face contacts and repeat prescriptions, and are likely to stimulate improvements in personal or practice prescribing. We believe that this system should be offered to all practices in the United Kingdom.
Shortage of Cardiothoracic Surgeons Is Likely by 2020
Authors: Atul Grover, Karyn Gorman, Timothy M. Dall, Richard Jonas, Bruce Lytle, Richard Shemin, Douglas Wood, Irving Kron
Journal: Circulation (2009)

Even as the burden of cardiovascular disease in the United States is increasing as the population grows and ages, the number of active cardiothoracic surgeons has fallen for the first time in 20 years. Meanwhile, the treatment of patients with coronary artery disease continues to evolve amid uncertain changes in technology. This study evaluates current and future requirements for cardiothoracic surgeons in light of decreasing rates of coronary artery bypass grafting procedures.Projections of supply and demand for cardiothoracic surgeons are based on analysis of population, physician office, hospital, and physician data sets to estimate current patterns of healthcare use and delivery. Using a simulation model, we project the future supply of cardiothoracic surgeons under alternative assumptions about the number of new fellows trained each year. Future demand is modeled, taking into account patient demographics, under current and alternative use rates that include the elimination of open revascularization. By 2025, the demand for cardiothoracic surgeons could increase by 46% on the basis of population growth and aging if current healthcare use and service delivery patterns continue. Even with complete elimination of coronary artery bypass grafting, there is a projected shortfall of cardiothoracic surgeons because the active supply is projected to decrease 21% over the same time period as a result of retirement and declining entrants.The United States is facing a shortage of cardiothoracic surgeons within the next 10 years, which could diminish quality of care if non-board-certified physicians expand their role in cardiothoracic surgery or if patients must delay appropriate care because of a shortage of well-trained surgeons.
Retraction of endorsement: European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates, and the European Society of Anaesthesiology Guideline: Non-anesthesiologist administration of propofol for GI endoscopy
Authors: P. Pelosi
Journal: Endoscopy (2012)

See also: European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates, and the European Society of Anaesthesiology Guideline: Non-anesthesiologist administration of propofol for GI endoscopyEndoscopy 2010; 42(11): 960-974DOI: 10.1055/s-0030-1255728
Assessment and Management of the Seriously Ill Patient Following Abortion
Authors: Duncan E. Reid
Journal: JAMA (1967)

In patients suffering from the consequences of a nonmedical abortion, generalization as to management has distinct limitations. Patients demand an hour-by-hour evaluation during the acute phase of the illness. No method of illegal abortion is more hazardous than injection of a substance into the uterus. Local damage may be extensive, and vascular and renal disturbances are prominent features. If instrumentation was used, infection is the problem and a favorable response usually follows removal of the infected conceptus. When hypotension persists, hysterectomy should be considered. When local abortifacients have been used, exploratory laparotomy should be considered to determine the status of the reproductive system. If there is marked tissue infarction and necrosis, hysterectomy should be performed. If there is one common denominator on which to base a judgment, it appears to reside in the kidney, which presumably reflects the status of tissue perfusion.
Double blind cross over trial of ipratropium and placebo in chronic rhinorrhoea.
Authors: N P von Haacke, V Moore-Gillon, L H Capel
Journal: BMJ (1983)

Non-steroidal anti-inflammatory drugs and oral lichenoid reactionsThe aetiology of lichen planus is unknown.Stress, autoimmunity, underlying mesodermal disease, and infective agents have all been suggested as possible causes but have not gained wide support.Many drugs can provoke eruptions that clinically and histologically are similar to or even identical with lichen planus.Such lichenoid reactions may be caused by, for example, gold salts, methyldopa, quinine, and beta-blockers' and may affect mucosal or cutaneous sites, either alone or together.We describe a probable association between treatment with non-steroidal anti-inflammatory drugs and oral lichenoid reaction.Case report sentially unchanged while the patient continued to take flurbiprofen. of the superior vermis.
Genes associated with rheumatoid arthritis and mild inflammatory arthritis. I. Major histocompatibility complex class I, II, and III allotypes.
Authors: A H Puttick, D C Briggs, K I Welsh, R Vaughan, E A Williamson, M Boyce, R K Jacoby, V E Jones
Journal: Annals of the Rheumatic Diseases (1990)

Patients with mild inflammatory arthritis (IA) were compared with patients with definite rheumatoid arthritis (RA) for abnormal frequencies of major histocompatibility complex (MHC) antigens and haplotypes to determine whether a genetic predisposition either to RA or to mild self-limiting arthritis/arthralgia was present in the patients with IA. In general the MHC antigens with abnormal frequencies found in patients with IA differed from those in patients with RA and were mainly at the A and B loci. In patients with IA the frequencies of HLA-A24, A25, B27, and B35 antigens were significantly higher than those of controls and HLA-DR5 and C4A4 were slightly raised. In contrast, in patients with RA abnormal frequencies of the MHC antigens DR4 and DR2 and the extended haplotypes associated with them [B62 BfS C4A3 C4B3 DR4 GLO2] and [B7 BfS C4A3 C4B1 DR2] confirmed the observations reported on other white populations. Thus MHC antigen associations with IA and RA differ sufficiently to suggest a different genetic basis for the two conditions.
Late airway response increases at repeat allergen challenge
Authors: J. B. RASMUSSEN
Journal: Allergy (1991)

The relationship between the immediate and late responses to repeated inhalations of allergen was studied. Sixteen male atopic asthmatics were challenged twice with an interval of 2 weeks. Forced expiratory volume in 1 s (FEV1) was measured serially over an 8-hour period after challenge. The method of provocation used implied that only slight differences between the immediate responses on the two provocation days were observed. However, differences in the late responses were demonstrated. Thus, the maximum percent change in FEV1 at the first and second provocation differed significantly in the late (P less than 0.01), but not in the immediate phase. The increase in maximal late response was greater than the small change in maximal immediate response (P less than 0.05). Further, the FEV1 values from 4 to 8 h post-challenge were in each recording significantly lower on the second day suggesting a more pronounced late bronchial response to repeat challenge. The results suggest that after one challenge specific airway reactivity, i.e., reactivity to allergen, at a subsequent rechallenge is increased in the late phase. This late phase hyperreactivity seems to persist for at least 2 weeks after allergen provocation.
Hypersensitivity to Meperidine
Authors: Burton A. Waisbren
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Observation of two cases within a month of an unusual cellular type of hypersensitivity to meperidine (Demerol) hydrochloride leads us to report this type of reaction, since in both cases numerous physicians were apparently unaware that it occurs. <h3>Report of Cases.—Case 1.—</h3> A 47-year-old woman had an intravertebral disk repaired in April 1976. She was an anxious woman, previously healthy, and was given multiple intramuscular injections of meperidine postoperatively. Ten days after surgery multiple raised reddened lesions developed and were diagnosed as a drug reaction to ampicillin. Ampicillin therapy was stopped, but she was in the hospital for six weeks receiving intramuscular meperidine on numerous occasions. Two weeks after discharge numerous abscesses developed all over her body; they did not respond to antibiotics and several attempts at surgical drainage. She was referred to one of us for treatment of these multiple abscesses. Numerous antibiotics and
DNA flow cytometry of the epidermis of patients with multiple epidermal carcinomas
Authors: GERDA FRENTZ, ULLA MOLLER
Journal: British Journal of Dermatology (1984)

We used DNA flow cytometry to determine whether the uninvolved skin of twenty-four patients with multiple epidermal cancers differed from normal skin with regard to its epidermal cell kinetics. We also studied the relationship between the cell kinetics and the type of cancer, previous exposure to ionizing or UV radiation, previous arsenic intake, skin type and coexisting psoriasis. Both exposed and unexposed skin was studied. In thirteen patients the S and G2M fractions of a monoclonal tumour were compared with the values in unexposed and exposed skin. The S and G2M fractions increased progressively from unexposed skin to exposed skin to tumour tissue. Patients who had developed both squamous and basal cell carcinoma differed from those who had developed only basal cell carcinoma by having a significantly higher G2M fraction in the exposed skin, and significantly higher S and G2M fractions in the unexposed skin. Patients exposed to ionizing radiation tended to show higher G2M fractions in exposed skin compared with the remaining individuals (P = 0.06). The presence of psoriasis, exposure to UVR or sunlight and previous arsenic ingestion did not appear to affect the results.
Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma
Authors: Joseph A. Sparano, Jeannette Y. Lee, Lawrence D. Kaplan, Alexandra M. Levine, Juan Carlos Ramos, Richard F. Ambinder, William Wachsman, David Aboulafia, Ariela Noy, David H. Henry, Jamie Von Roenn, Bruce J. Dezube, Scot C. Remick, Manisha H. Shah, Lawrence Leichman, Lee Ratner, Ethel Cesarman, Amy Chadburn, Ronald Mitsuyasu
Journal: Blood (2009)
Effect of metoclopramide on gastric function in man
Authors: A. M. Connell, J. D. George
Journal: Gut (1969)

The effects of metoclopramide on gastric emptying and gastric secretion have been assessed in man using the double sampling test meal. Metoclopramide increases the rate of emptying of the stomach. The magnitude of the effect is directly related to the initial emptying time. Metoclopramide has no effect on the acid response to a water test meal.
Andrew Wakefield drops libel case against Channel 4
Authors: Clare Dyer
Journal: BMJ (2007)

Andrew Wakefield, the British gastroenterologist whose comments at a press conference in 1998 sparked a scare over the safety of the measles, mumps, and rubella vaccine (MMR vaccine), has dropped his libel action against Channel 4. 

The case was due to go to trial shortly after the end of a three month disciplinary hearing, which Dr Wakefield faces at the General Medical Council this July. 

RadcliffesLeBrasseur, the solicitors acting for the Medical Protection Society, which was funding the libel case, said in a …
Carinal resection for stenotic tuberculous tracheitis.
Authors: R Natkunam, C Y Tse, B H Ong, P Sriragavan
Journal: Thorax (1988)

Tuberculosis of the tracheobronchial tree is usually considered to be secondary to pulmonary tuberculosis and generally resolves with treatment of the primary disease.'We report a case of stricture of the trachea and right main bronchus occurring during antituberculosis treatment.
Mitochondrial and nuclear genes present conflicting portraits of human origins
Authors: J. Hey
Journal: Molecular Biology and Evolution (1997)

Human mitochondrial DNA (mtDNA) sequences reveal an abundance of polymorphic sites in which the frequencies of the segregating bases are very different. A typical polymorphism involves one base at low frequency and the other base at high frequency. In contrast, nuclear gene data sets tend to show an excess of polymorphisms in which both segregating bases are at intermediate frequencies. A new statistical test of this difference finds significant differences between mtDNA and nuclear gene data sets reported in the literature. However, differences in the polymorphism patterns could be caused by different sample origins for the different data sets. To examine the mtDNA-nuclear difference more closely, DNA sequences were generated from a portion of the X-linked pyruvate dehydrogenase E1 alpha subunit (PDHA1) locus and from a portion of mitochondrial control region I (CRI) from each of eight individuals, four from sub-Saharan Africa. The two genes revealed a significant difference in the site frequency distribution of polymorphic sites. PDHA1 revealed an excess of intermediate-frequency polymorphisms, while CRI showed an excess of sites with the low-high frequency pattern. The discrepancy suggests that mitochondrial variation has been shaped by natural selection, and may not be ideal for some questions on human origins.
Functional Gastrointestinal Disease
Authors: Bertram Fleshler
Journal: JAMA (1968)

The strength of this slim volume lies in the emphasis it places on listening to the patient and on proper interviewing techniques for understanding and managing patients' problems. Since these concepts are neither original nor particularly controversial, despite Dr. Palmer's attempt to set up a "scientist vs. clinician" argument, the value of the book is somewhat dubious. Dr. Palmer's general bias is illustrated by the quotation concerning the purpose of "laboratory physiology's unending advances"; "I doubt that many of them will ever be of much help to the patient, nor are they intended to be." Dr. Palmer presents a deliberately personal statement, essentially devoid of references to the literature, of his beliefs regarding entities such as peptic ulcer, ulcerative colitis, the irritable gut, esophageal motor disturbances, and many other disorders involving the gastrointestinal tract. The discussion of these entities is, by design, incomplete—the main thrust of the text is the
A Case of Cerebral Cholesteatoma
Authors: I. R. S. Gordon
Journal: BMJ (1941)

The following case seems to be unusual enough to merit description.Case ReportThe patient, a man aged 36, was admitted to hospital in March, 1940, complaining of headaches, attacks of giddiness, and a right-sided hemiplegia.He was quite well until 1933, when he began to suffer from attacks of giddiness, after which he could hear and see objects but was unable to understand what was said to him.These attacks continued to occur more often until in 1936 they recurred about once a month, and were associated with frequent headaches, both frontal and temporal.At this time there were no visual defects or loss of consciousness, his blood pressure was 125/90, and no abnormal physical signs were found.His headaches were controlled by 10 grains of aspirin.His case was diagnosed as petit mal.
A PERSONAL EXPERIENCE WITH SPRUE
Authors: S. M. Lambert
Journal: JAMA (1923)

Along the coast of North Queensland, Australia, there are endemic areas of sprue. In December, 1918, I began field work for the control of hookworm disease in this region, succeeding a man who had been invalided home with sprue. Previous to his departure, I had lived in close association with this man for six weeks. In January, 1919, I developed a condition that was diagnosed as sprue by Dr. Philip S. Clarke, a physician of Cairns, who has had years of experience with this infection. There were no mouth symptoms at first, but I had all the gastro-intestinal symptoms attendant on the disease: intestinal fermentation, and the characteristic frothy, straw colored stools, enormous in amount, which would begin early in the morning and continue until afternoon. These were accompanied by a mental depression out of all relation to the condition. I restricted my diet to bananas and milk, and this
A Genetic Variant in the Promoter of the Siglec8 Gene is Associated with Wheeze in a Brazilian Population
Authors: A.V. Grant, B.S. Bochner, J.P. Guo, M.I. Araujo, E.V. Ponte, A.A. Cruz, T.H. Beaty, P.S. Gao
Journal: Journal of Allergy and Clinical Immunology (2007)
PTU-118 Long-Term outcome in Severe Alcoholic Hepatitis
Authors: J R Potts, S A Goubet, M A Heneghan, S Verma
Journal: Gut (2013)

<h3>Introduction</h3> Although short-term outcome in severe alcoholic hepatitis (SAH) is well described, its long-term course is largely unknown. Our aim was to assess long-term outcome in SAH. <h3>Methods</h3> Cohort study of patients with SAH (Discriminant Function ≥32) admitted to our institute, identified retrospectively 2007–2009 then prospectively until August 2011. Clinical and laboratory parameters were recorded at accession and subsequent follow-up. Kaplan-Meier (KM) and Cox proportional hazards analyses were performed. Data are presented as mean ±SD or median (IQR). <h3>Results</h3> 109 consecutive patients with SAH were included (63.3% men, age 49.6 ± 9.4yrs) with median follow-up of 40.7 mths (95% CI 37.2–44.3). At accession median DF was 58 (34), MELD 23 (6) and Glasgow Alcoholic Hepatitis Score 8 (2). 55.0% drank spirits, 86.2% had established cirrhosis and 65.1% received corticosteroid and/or pentoxifylline therapy. Prevalence of hepatic encephalopathy (HE), infection and hepatorenal syndrome (HRS) were 38.5%, 47.7% and 18.3% respectively. Median survival was 22.4 mths (95% CI 11.1–33.7), overall mortality being 57.8% (n = 63). All except two deaths were liver related and 33.3% occurred during the index admission. In univariate analysis, AST, urea, creatinine, white cell count, and the presence of HE, HRS and infection were statistically significantly associated with mortality (p &lt; 0.10 for all), though only HRS was an independent predictor in multivariate analysis (HR 3.842, 95% CI 2.018–7.312, p &lt; 0.0001). However, all baseline factors were associated with short-term mortality and none predicted death beyond 3 mths. Of those surviving index hospitalisation (n = 87, 86 with available data), 37 (43.0%) were abstinent at last follow-up. Recidivism occurred in the remaining 49 (57.0%), of whom 33 continued to drink and 16 relapsed after initial abstinence. Abstainers were significantly less likely to require hospital readmission than those with any recidivism (median readmissions/patient 1 vs. 5, p = 0.001). In a further univariate analysis, inpatient paracetamol use and abstinence status were associated with mortality after the index hospitalisation (p = 0.032 and 0.010 respectively). Only abstinence remained an independent predictor in multivariate analysis (HR 0.402 (95% CI 0.183–0.883), p = 0.023). KM analysis showed 3 year survival to be significantly higher in abstainers (75.3%) compared to relapsed and continued drinkers (40.2% and 21.0% respectively, p = 0.005). <h3>Conclusion</h3> Recidivism is common after SAH (~65%) and is the main determinant of the high long-term mortality (~60%), which appears unrelated to the severity of the index episode. Novel strategies to improve abstinence following SAH are urgently needed, especially in view of the increasing numbers of deaths due to alcohol-related liver disease in the UK. <h3>Disclosure of Interest</h3> None Declared
High-Technology Medicine in China
Authors: Gail E. Henderson, Elizabeth A. Murphy, Samuel T. Sockwell, Zhou Jiongliang, Shen Qingrui, Li Zhiming
Journal: New England Journal of Medicine (1988)

During the past decade, the focus of medical care in China has moved from the barefoot doctor's clinic to the urban medical center. Techniques have shifted from the use of low-cost tools of prevention to that of expensive, imported diagnostic equipment. The use of high-technology medicine in any country raises three fundamental questions: Is it a reasonable use of limited resources, who will have access to it, and how will it be paid for? Given China's unique record of health achievements in primary care, its use of high-technology medicine has implications not only for its own citizens but for other . . .
Analysis of Alterations in the Retinoblastoma Gene and Tumor Grade in Bone and Soft-Tissue Sarcomas
Authors: J. S. Wunder, A. A. Czitrom, R. Kandel, I. L. Andrulis
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Analysis of Alterations in the Retinoblastoma Gene and Tumor Grade in Bone and Soft-Tissue Sarcomas Get access Jay S. Wunder, Jay S. Wunder Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrei A. Czitrom, Andrei A. Czitrom Search for other works by this author on: Oxford Academic PubMed Google Scholar Rita Kandel, Rita Kandel Search for other works by this author on: Oxford Academic PubMed Google Scholar Irene L. Andrulis Irene L. Andrulis * * Correspondence to: Irene L. Andrulis, PhD, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada M5G 1X5. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 3, 6 February 1991, Pages 194–200, https://doi.org/10.1093/jnci/83.3.194 Published: 06 February 1991 Article history Received: 06 August 1990 Revision received: 13 November 1990 Accepted: 20 November 1990 Published: 06 February 1991