tbuckley/cabot-search huggingface dataset:
Emergency medical service. The concept and coronary care
Authors: W. F. Renner
Journal: JAMA (1974)

GOVERNMENTAL decisions at the national level to grant a high priority to the promotion of emergency medical services (EMSs), backed by appropriate funding, have catalyzed revolutionary changes in the concept of emergency medical care in the United States. The Emergency Medical  Systems Act of 1973 is providing $185 million over a three-year period for EMS improvements throughout the country in a program being administered by the Department of Health, Education, and Welfare (HEW).  The Federal  Commission (FCC) has sponsored a study by the Interdepartment Radio Committee in coordination with representatives of the FCC and the medical community on Communications in Support of Emergency Medical Services and a second study by Advanced Technology Systems of Arlington, Va, under FCC contract, on Rule Changes Required for Emergency Medical Communications. The FCC now is prepared to adopt rules changes based on recommendations from these studies that will facilitate the establishment of
Single-nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma
Authors: A J Greenberg, A M Lee, D J Serie, S K McDonnell, J R Cerhan, M Liebow, D R Larson, C L Colby, A D Norman, R A Kyle, S Kumar, S V Rajkumar, R B Diasio, S L Slager, C M Vachon
Journal: Leukemia (2012)
Cardiomyogenic Potential of C-Kit <sup>+</sup> –Expressing Cells Derived From Neonatal and Adult Mouse Hearts
Authors: Marc-Michael Zaruba, Mark Soonpaa, Sean Reuter, Loren J. Field
Journal: Circulation (2010)

C-kit is a receptor tyrosine kinase family member expressed in hematopoietic stem cells. C-kit is also transiently expressed in cardiomyocyte precursors during development and in a rare cell population in the normal adult heart. In the present study, the cardiomyogenic potential of c-kit(+) cells isolated from normal neonatal, normal adult, and infarcted adult mouse hearts was evaluated.Magnetic activated cell sorting was used to prepare c-kit(+) cells from the hearts of ACT-EGFP/MHC-nLAC double transgenic mice. These animals exhibit widespread enhanced green fluorescent protein (EGFP) expression and cardiomyocyte-restricted nuclear beta-galactosidase activity, thus permitting simultaneous tracking of cell survival and differentiation. A subset of the c-kit(+) cells from double transgenic neonatal hearts acquired a cardiomyogenic phenotype when cocultured with fetal cardiomyocytes (2.4% of all EGFP(+) cells screened) but rarely when cultured alone or when cocultured with mouse fibroblasts (0.03% and 0.05% of the EGFP(+) cells screened, respectively). In contrast, c-kit(+) cells from normal adult double transgenic hearts failed to undergo cardiomyogenic differentiation when cocultured with nontransgenic fetal cardiomyocytes (>18 000 EGFP(+) cells screened) or when transplanted into normal or infarcted adult mouse hearts (14 EGFP(+) grafts examined). A single c-kit(+) cell from an infarcted double transgenic adult heart was observed to acquire a cardiomyogenic phenotype in coculture (>37 000 EGFP(+) cells screened).These data suggest that the ability of cardiac-resident c-kit(+) cells to acquire a cardiomyogenic phenotype is subject to temporal limitations or, alternatively, that the cardiomyogenic population is lost. Elucidation of the underlying molecular basis may permit robust cardiomyogenic induction in adult-derived cardiac c-kit(+) cells.
Aortic input impedance in heart failure.
Authors: C J Pepine, W W Nichols, C R Conti
Journal: Circulation (1978)

The input impedance of the systemic circulation was calculated from recordings of pulsatile pressure and flow in the ascending aorta of 20 patients. Ten patients had clinical and hemodynamic evidence of heart failure. The other 10 subjects had no clinical evidence of heart failure and were used as a control group. In the heart failure patients, both input resistance and characteristic impedance (index of aortic distensibility) were significantly increased compared to pressure- and age-matched control subjects. Oscillations of impedance moduli, represented by the difference between maximum and minimum moduli, were also significantly increased in the heart failure patients compared with the control subjects. The increased characteristic input impedance in these heart failure patients suggests that the human aorta is stiffer in heart failure, and the larger oscillations in the impedance spectrum indicate an increase in pressure and flow wave reflections. From reflected wave theory in elastic tubes, reflected pressure waves add to the amplitude of incident pressure waves at the entrance of the system, whereas reflected flow waves subtract from the magnitude of the forward flow. Thus, changes in aortic distensibility could have an important influence on the pulsatile function of the failing left ventricle.
Measurement of the Interstitial Pressure in Subcutaneous Tissue in Dogs
Authors: HANS JØRGEN LADEGAARD-PEDERSEN
Journal: Circulation Research (1970)

A probe consisting of a cotton thread fitted inside a 15-cm Teflon tube with an inner diameter of 0.8 mm and connected to a transducer was used to measure the interstitial pressure in the subcutaneous tissue in six anesthetized dogs. The measurements were reproducible with a standard deviation of ±0.64 mm Hg. In six dogs the mean pressure in the subcutaneous tissue of the thorax was --2.74 mm Hg (range --3.25 to --1.99 mm Hg). After hemorrhage and dextran (10%) infusion, the mean pressure decreased by 1.70 mm Hg. After infusion of lactated Ringer's solution, the pressure increased to the control values.
L'examen par capsule endoscopique de l'intestin grêle détecte des néoplasies asymptomatiques chez les patients présentant un syndrome HNPCC
Authors: JC Saurin, E Ben Soussan, T Maniere, PN d'Halluin, M Gaudric, C Cellier, D Heresbach, JL Gaudin
Journal: Endoscopy (2008)

Rationnel: L'adénocarcinome de l'intestin grêle est une tumeur rare appartenant au spectre du syndrome HNPCC, survenant à un âge moyen de 39 à 49 ans selon les études, faisant découvrir la maladie une fois sur 4. Dans la population générale, la survie globale de ces tumeurs est de 26% à 5 ans. Identifier des lésions pré-néoplasiques ou des cancers précoces pourrait permettre une prévention ou une amélioration du pronostic de ces tumeurs. But: Evaluer l'apport d'une recherche systématique par capsule endoscopique comparativement à l'entéroscanner de tumeurs du grêle dans cette population à risque 100 fois supérieur à la population générale.
Cytoplasm of Colonic Mucosal Cells as Site of Antigen in Ulcerative Colitis
Authors: Janis V. Klavins
Journal: JAMA (1963)

THERE IS increasing evidence that ulcerative colitis is associated with immunological disorders. Many investigators have shown that an antibody is present in the sera of patients with ulcerative colitis which reacts with extracts of the colonicmucosa. The present studies were made in an attempt to demonstrate the localization of an antigen or antigens in the colon. <h3>Material and Methods</h3> Seven adults and four children suffering from ulcerative colitis were studied. Sera from these 11 patients were collected, frozen, and stored at —12 C (10.4 F). As controls, sera from five individuals without ulcerative colitis were used. These were collected from a normal individual, a patient with Whipple's disease, one with adenocarcinoma of the colon, a patient with diverticulitis, and a patient with viral hepatitis. Colonic tissue containing the entire wall was obtained from one patient with diverticulitis, one with adenocarcinoma of colon, and one with a normal colon. The
Hypersensitivity of bcr-abl-positive progenitors to hyperthermia in patients with chronic myeloid leukemia
Authors: SFT Thijsen, JW van Oostveen, GJ Schuurhuis, AP Theijsmeijer, CBM Oudejans, IJ van Wijk, MMAC Langenhuijsen, GJ Ossenkoppele
Journal: Leukemia (1997)
Haem iron intake in 12-36 month old children depleted in iron: case-control study
Authors: M. Mira, G. Alperstein, M. Karr, G. Ranmuthugala, J. Causer, A. Niec, A.-M. Lilburne
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To compare the intakes of haem and non-haem iron in iron depleted and iron replete children. <b>Design</b>: Case-control study. <b>Setting</b>: Early Childhood Centres and a long day care centre in Sydney, Australia. <b>Subjects</b>: Children aged 12-36 months depleted in iron and controls matched for age and sex. <b>Mean outcome measures</b>: Iron status by using plasma ferritin concentration. A three day weighed dietary intake record completed by the parents. Risk factors for iron deficiency assessed by questionnaire. <b>Results</b>: Fifty six iron depleted and 68 iron replete children participated. The average daily intake ofhaem iron was significantly lower in the iron depleted group (t=2.392, P=0.018); there was a tendency towards a lower average daily intake of non-haem iron (t=1.724, P=0.086) and vitamin C (t=1.921, P=0.057) for iron depleted children. Low intake ofhaem iron (&lt;0.71 mg/day) was significantly associated with iron depletion with an odds ratio of 3.0 (P=0.005). The proportion of iron depleted children who were given whole cows9 milk before 12 months of age was almost double that of iron replete children; multivariate analysis showed that both haem iron intake and age of introduction of cows9 milk were independently associated with iron depletion. <b>Conclusions</b>: The results of this study show that, in young children in developed countries, a lower haem iron intake is a major risk factor for iron depletion; the introduction of whole cows9 milk before 12 months is further confirmed as a risk factor. Parental education on nutrition should now focus on these two aspects of nutrition for infants and young children. <h3>Key messages</h3> Iron deficiency is the most common nutritional deficiency worldwide Iron deficiency may cause lowering of developmental scores and may impair behaviour Iron depleted 1 and 2 year old children have lower haem iron intake Introduction of cows9 milk as the main milk drink should be delayed until after 12 months of age Public health campaigns to reduce iron depletion and iron deficiency in preschool children should encourage adequate meat intake
Inhaled corticosteroids may decrease the severity of chronic cough
Authors: T D Yan
Journal: Thorax (2004)

▴ Chaudhuri R, McMahon AD, Thomson LJ, et al . Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. J Allergy Clin Immunol2004;113:1063–70 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] . This double blind, randomised, placebo controlled, crossover study was performed in 88 patients who had chronic cough for more than 1 year. Patients were treated with inhaled fluticasone 500 μg or matching placebo … [1]: {openurl}?query=rft.jtitle%253DJournal%2Bof%2BAllergy%2Band%2BClinical%2BImmunology%26rft.stitle%253DJournal%2Bof%2BAllergy%2Band%2BClinical%2BImmunology%26rft.aulast%253DChaudhuri%26rft.auinit1%253DR.%26rft.volume%253D113%26rft.issue%253D6%26rft.spage%253D1063%26rft.epage%253D1070%26rft.atitle%253DEffect%2Bof%2Binhaled%2Bcorticosteroids%2Bon%2Bsymptom%2Bseverity%2Band%2Bsputum%2Bmediator%2Blevels%2Bin%2Bchronic%2Bpersistent%2Bcough.%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jaci.2004.03.019%26rft_id%253Dinfo%253Apmid%252F15208586%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/j.jaci.2004.03.019&link_type=DOI [3]: /lookup/external-ref?access_num=15208586&link_type=MED&atom=%2Fthoraxjnl%2F59%2F9%2F751.atom [4]: /lookup/external-ref?access_num=000222091000010&link_type=ISI
Edematous, scarring vasculitic panniculitis: A new multisystemic disease with malignant potential
Authors: Ramon Ruiz-Maldonado, Fernando Millan Parrilla, Ma de la Luz Orozco-Covarrubias, Cecilia Ridaura, Lourdes Tamayo Sanchez, Carola Duran McKinster
Journal: Journal of the American Academy of Dermatology (1995)
Altered expression of heme oxygenase-1 in the livers of patients with portal hypertensive diseases
Authors: Nobuya Makino, Makoto Suematsu, Yoshiaki Sugiura, Hiroyasu Morikawa, Susumu Shiomi, Nobuhito Goda, Tsuyoshi Sano, Yuji Nimura, Keizo Sugimachi, Yuzuru Ishimura
Journal: Hepatology (2001)

This study was designed to determine changes in expression of heme oxygenase (HO)–1, the stress–inducible and carbon monoxide-producing enzyme, in normotensive and portal hypertensive human livers. GTS–1, a monoclonal antibody against rat HO–1 cross–reacted with the human HO–1 and blocked its enzyme activity, allowing us to examine the activity and localization of HO–1. In controls, approximately 50% of the total HO activity was from HO–1 as judged by the sensitivity to GTS–1, while the rest of activity was from other isozymes such as HO–2. HO–1 was expressed mainly in a subpopulation of Kupffer cells, and the expression in hepatic stellate cells, sinusoidal endothelial cells, and hepatocytes was little, if any. The HO–1 expression exhibited quite different pictures in the livers of portal hypertensive diseases. In cirrhotic livers, which undergo portal hypertension through increases in intrasinusoidal resistance and regenerative changes in the parenchyma, HO–1 occurred in a majority of Kupffer cells and was also observed in hepatocytes. Consequently, the total HO–1 activities became significantly greater in these tissues than those from normal individuals. By contrast, livers of idiopathic portal hypertension that are characterized by an increase in presinusoidal resistance displayed a significant decrease in the HO–1 expression in Kupffer cells, and its hepatocellular expression was not detectable. Although factors involved in altered HO–1 expression in these cells remain unknown, the results suggest that Kupffer cells could alter their expression of HO–1 in response to local hemodynamic changes associated with chronic portal hypertension in humans.
Coaxing the liver into preventing autoimmune disease in the brain
Authors: Brad E. Hoffman, Roland W. Herzog
Journal: Journal of Clinical Investigation (2008)

The liver has several unique immunological properties that affect T cell activation and immune regulation. Recent studies have uncovered opportunities for the treatment of genetic disease by directing expression of the functional therapeutic protein to hepatocytes. In a new study in this issue of the JCI, Lüth and colleagues demonstrate that hepatic expression of a brain protein is protective against neuroinflammatory disease in a mouse model of human MS (see the related article beginning on page 3403). Suppression of autoimmunity was dependent on transgene expression in the liver and was mediated by induction of antigen-specific CD4+CD25+Foxp3+ Tregs. These findings suggest that the introduction of antigens to the liver may have potential as a preventative or therapeutic intervention for autoimmune disease.
<i>Helicobacter pylori</i> Eradication Therapy for Nonulcer Dyspepsia
Authors: Ward B. Buckingham
Journal: Annals of Internal Medicine (2002)

Letters2 April 2002Helicobacter pylori Eradication Therapy for Nonulcer DyspepsiaWard B. Buckingham, MDWard B. Buckingham, MDCoos Bay, OR 97420Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-7-200204020-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I am troubled by Laine and colleagues' conclusion that there is little support for the use of H. pylori eradication therapy in patients with nonulcer dyspepsia (1). Since infected persons have a two- to sixfold increased risk for gastric cancer and certain types of lymphoma, isn't it reasonable to therefore offer curative therapy? Do we really have longitudinal studies of sufficient duration to know the actual long-term risks associated with continued H. pylori infection? In the same issue, the findings of Ohkusa and associates that precancerous gastric lesions improved after eradication of H. pylori(2) certainly support the ...References1. Laine L, Schoenfeld P, Fennerty MB. Therapy for Helicobacter pylori in patients with nonulcer dyspepsia. A meta-analysis of randomized, controlled trials. Ann Intern Med. 2001;134:361-9. [PMID: 11242496] LinkGoogle Scholar2. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, et al . Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann Intern Med. 2001;134:380-6. [PMID: 11242498] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Coos Bay, OR 97420 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImprovement in Atrophic Gastritis and Intestinal Metaplasia in Patients in Whom Helicobacter pylori Was Eradicated Toshifumi Ohkusa , Kazuhiko Fujiki , Ichizen Takashimizu , Jiro Kumagai , Toru Tanizawa , Yoshinobu Eishi , Tetsuji Yokoyama , and Mamoru Watanabe Therapy for Helicobacter pylori in Patients with Nonulcer Dyspepsia Loren Laine , Philip Schoenfeld , and M. Brian Fennerty Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia John M. Bozdech Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia Loren Laine , M. Brian Fennerty , and Philip Schoenfeld Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia Paul Moayyedi , Jonathan Deeks , and David Forman Metrics 2 April 2002Volume 136, Issue 7Page: 555KeywordsGastric cancerHelicobacter pyloriLesionsLongitudinal studiesLymphoma ePublished: 2 April 2002 Issue Published: 2 April 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ABC of mental health: Psychological treatments:
Authors: Phil Richardson
Journal: BMJ (1997)

The range of procedures that pass for a psychological treatment is broad.Over 450 distinct forms of psychotherapy have been identified, although many can be reduced to a narrower set of therapy types.The great diversity of available psychological treatments remains a potential source of confusion for referrers, service users, and purchasers.Confusion may also surround standards of training and practice.Training in psychotherapy and counselling abounds in Britain, which has no formal registration for either activity and no single professional accreditation body.The recent review of psychotherapy services in the NHS underlines the efficacy and importance of psychological treatments for mental disorders.A joint statement from the British Psychological Society and Royal College of Psychiatrists identifies the need to develop integrated psychological therapy services within the NHS that can offer assessment, treatment, and training in psychological treatments.Referral to a coordinated psychological treatments service may obviate the need for general practitioners and others to make difficult referral decisions about particular forms of treatment.However coordinated treatment services are not yet widely available, and referrers may be left to find their way through a maze of local services.
Mutations in exon 3 of the glycogen debranching enzyme gene are associated with glycogen storage disease type III that is differentially expressed in liver and muscle.
Authors: J Shen, Y Bao, H M Liu, P Lee, J V Leonard, Y T Chen
Journal: Journal of Clinical Investigation (1996)

Glycogen storage disease type HI (GSD-III), an autosomal recessive disease, is caused by deficient glycogen debranching enzyme (GDE) activity. Most GSD-III patients are GDE deficient in both liver and muscle (type IIIa), and some GSD-III patients have GDE absent in liver but retained in muscle (type IIIb). The molecular basis for this enzymatic variability is largely unknown. In the present study, the analysis of the GDE gene in three GSD-IIIb patients by single-strand conformation polymorphism (SSCP), DNA sequencing, restriction analysis, and family studies, revealed each of them as being a compound heterozygote for two different mutations. The first mutant alleles in all three patients involved mutations in exon 3 at amino acid codon 6 of the GDE protein. Two had an AG deletion at nucleotides 17 and 18 of the GDE cDNA (17delAG) which resulted in change of subsequent amino acid sequence and a truncated protein (25X); the other had a C to T transition at nucleotide 16 of the cDNA which changed a Glutamine codon to a stop codon (Q6X). The 17delAG mutation was also found in 8 of the 10 additional GSD-IIIb patients. The Q6X mutation was found in one of the remaining two GSD-IIIb patients. These two mutations were not found in any of the 31 GSD-IIIa patients, 2 GSD-IIId patients, nor 28 unrelated normal controls. The second mutant alleles in each of the three GSD-IIIb patients were R864X, R1228X, and W68OX. The R864X and R1228X were not unique for GSD-IIIb as they were also found in GSD-IIIa patients (frequency of 10.3% and 5.2% in Caucasian patients, respectively). Our data demonstrated that both IIIa and IIIb had mutations in the same GDE gene and established for the first time the molecular basis of GSD-III that differentially expressed in liver and muscle. The striking and specific association of exon 3 mutations with GSD-IIIb may provide insight into mechanisms controlling tissue-specific expression of the GDE gene. The identification of exon 3 mutations has clinical significance as well because it distinguished GSD-IIIb from IIIa hence permitting diagnosis from a blood sample rather than a more invasive muscle biopsy.
Effects of Tirofiban Maintenance 24 or 48 Hours in Patients with Anterior Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Hakan Muhammed Taş, Ziya Simsek, Arif Ayan, Ugur Aksu, Selami Demirelli, Zakir Lazoglu, Yavuzer Koza, Bedri Seven, Mahmut Açıkel, Huseyin Senocak
Journal: Journal of the American College of Cardiology (2013)
Increase of Ventricular Excitability Threshold by Hyperpotassemia
Authors: Borys Surawicz
Journal: JAMA (1965)

Hyperpotassemia increases excitability threshold of the ventricular myocardium and may be responsible for the failure of the implanted pacemakers. The following observations support this hypothesis: (1) A patient with hyperpotassemia became unresponsive to stimulation by a nondefective, implanted pacemaker. (2) In another patient with a transvenous pacemaker, excitability threshold increased from less than one volt (v) to more than six v when plasma potassium concentration was raised from 4.0 to 7.1 mEq/liter. (3) In dogs, ventricular excitability threshold increased with increasing potassium concentration. These observations suggest that in patients with implanted pacemakers hyperpotassemia must be prevented and promptly treated.