tbuckley/cabot-search huggingface dataset:
Economic evaluation of methyl aminolaevulinate-based photodynamic therapy in the management of actinic keratosis and basal cell carcinoma
Authors: K. Caekelbergh, L. Annemans, J. Lambert, R. Roelandts
Journal: British Journal of Dermatology (2006)

Journal Article Economic evaluation of methyl aminolaevulinate‐based photodynamic therapy in the management of actinic keratosis and basal cell carcinoma Get access K. Caekelbergh, K. Caekelbergh HEDM (Health Economics and Disease Management), Brussels, Belgium Search for other works by this author on: Oxford Academic Google Scholar L. Annemans, L. Annemans HEDM (Health Economics and Disease Management), Brussels, BelgiumFaculty of Medicine, University of Ghent, Ghent, Belgium Lieven Annemans. E‐mail: lannemans@be.imshealth.com Search for other works by this author on: Oxford Academic Google Scholar J. Lambert, J. Lambert Department of Dermatology, University Hospital Antwerp, Antwerp, Belgium Search for other works by this author on: Oxford Academic Google Scholar R. Roelandts R. Roelandts Photodermatology Unit, University Hospital Leuven, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 4, 1 October 2006, Pages 784–790, https://doi.org/10.1111/j.1365-2133.2006.07483.x Published: 01 October 2006 Article history Accepted: 18 May 2006 Published: 01 October 2006
Procedural skills of practicing pulmonologists. A national survey of 1,000 members of the American College of Physicians.
Authors: T G Tape, L L Blank, R S Wigton
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We surveyed pulmonologists to determine which procedures they do in practice, where they learned the procedures, and how much training they recommend to attain and maintain clinical competence in each. We mailed a survey to a random sample of 1,000 members of the American College of Physicians who were identified as practicing pulmonologists; 755 (75%) responded. Respondents performed a variety of pulmonary procedures, an average of 17 of the 29 listed. Pulmonologists who were more recent graduates, who worked longer hours, and who were involved in critical care did a greater variety of procedures. Only 26% of practicing pulmonologists currently do all the procedures required for board certification in pulmonary medicine. For each of 13 specific procedures, the number reported done in the past year was generally unrelated to practice factors. Many respondents who learned procedures in practice did so without formal training or supervision. Respondents' recommendations regarding numbers of procedures required to attain or maintain competence did not vary greatly. Pulmonologists vary considerably in the types of procedures they do. Their opinions about the training needed for competence help to better define requirements for training programs. More attention should be focused on training and certifying practicing pulmonologists in procedures learned after formal fellowship training.
MicroRNA-Mediated Control of Oligodendrocyte Differentiation
Authors: Xianghui Zhao, Xuelian He, Xiaolei Han, Yang Yu, Feng Ye, Ying Chen, ThaoNguyen Hoang, Xiaomei Xu, Qing-Sheng Mi, Mei Xin, Fan Wang, Bruce Appel, Q. Richard Lu
Journal: Neuron (2010)
Clonal T-large granular lymphocyte proliferations associated with clonal B cell lymphoproliferative disorders: report of eight cases
Authors: T Papadaki, K Stamatopoulos, C Kosmas, G Paterakis, V Kapsimali, G Kokkini, Th Economopoulos, K Stefanoudaki-Sofianatou, T Marinakis, E Gardikas, T Kalmantis
Journal: Leukemia (2002)
Medicare Prescription Drug Coverage Gap
Authors: Scott A. Berkowitz, Gary Gerstenblith, Gerard F. Anderson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General practitioner contract
Authors: T. G Plunkett
Journal: BMJ (1990)

puter numbers?A unique identifying number could be used by general practitioners, family practitioner committees, and hospitals for records, specimens, and exchange of information.At the moment, even within a district, hospitals have their own numbering systems, and a patient may have several hospital numbers.If this is not considered now we may lose a valuable opportunity to improve communication within the health service.Despite the investment in computers we could discover that they cannot talk to one another.Would the NHS number fulfil this role?
Fœtid AND SWEATING FEET.
Authors: J. F. Jenkins
Journal: JAMA (1883)

Red Oak, Iowa, Oct. 25, 1883. <h3>Dear Editor:</h3> — In theAmerican Medical Journalof October 13, p. 428, among the "Medical Progress" articles, there is one for " Relief of Fœtid Sweating Feet by Subnitrate of Bismuth," a remedy which I have never tried, but will inclose a formula that with the correct observation of the instructions has been very certain of success in all the cases on which I know of its being tried: [unk] Aluminii et Ammo. Exic., grs. 2 Acidi Boracici........... " 2 Aquæ Simp. or Rosæ..... " 35 Mix. Sig.: Apply with soft sponge without rubbing, just as soon as the shoes and stockings are removed, while the feet are yet moist. This is quite necessary, as also the care not to rub. Let this be repeated every two or three days, in the evening, and I have yet to know of its failure to check the profuse
Death begets failure in the heart
Authors: Roger S.-Y. Foo, Kartik Mani, Richard N. Kitsis
Journal: Journal of Clinical Investigation (2005)

Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.
P80Cannabinoid receptor CB2 prevents development of heart failure in a murine model of pressure overload
Authors: GD Duerr, JC Heinemann, J Kley, W Roell, A Ottersbach, A Zimmer, B Lutz, A Welz, O Dewald
Journal: Cardiovascular Research (2014)

Purpose: Cardiac adaptation to pressure overload is associated with inflammatory reaction, which untreated leads to myocardial fibrosis and heart failure. We have recently demonstrated that endogenous cannabinoids and the cannabinoid receptor 2 (CB2) are activated and associated with persistent inflammation in hypertrophic myocardium of patients with aortic valve stenosis. Therefore, we investigated the role of the CB2 in a mouse model of pressure overload. Methods: Transverse aortic constriction was performed in CB2-/--mice and their wildtype littermates (CB2+/+; n=8-12/group). Taqman® RT-qPCR analysis was performed after 3 and 7 days. After M-mode echocardiography and Millar® pressure-volume left ventricular catheter at days 7 and 21, hearts were harvested and subjected to immunohistochemical analysis. Results: Heart weight/tibia length-ratio and cardiomyocyte diameter as hypertrophy parameters were comparable in CB2-/--mice and their littermates after 7 and 21 days. Collagen area measurements using picrosirius red planimetry revealed a significantly increased collagen deposition in CB2+/+ mice after 7 and 21 days than in sham mice. CB2-/--mice presented with more collagen deposition than in littermates at the same time points due to intramural confluent infarcted areas. We found also significantly more α-smac positive, collagen producing myofibroblasts in the CB2-/--mice after 7 days. Echocardiography showed significant worse left ventricular function in CB2-/--mice compared to their littermates after 21 days. Analysis of inflammatory response after 3 days revealed significantly induced CCL2 mRNA-expression in CB2+/+-mice compared to sham, being also significantly higher than in the CB2-/--mice. The resolution of inflammatory response was significantly delayed in CB2-/--mice as shown by IL-10 mRNA-expression. The cellular analysis after 7 days revealed significantly higher macrophage density in both genotypes when compared to shams, whereas CB2-/--mice had significantly more macrophage accumulation than their littermates. Macrophage maturation factor osteopontin-1 was only transiently, but significantly increased in CB2+/+-mice after 7 days in contrast to the continuous increase of it in CB2-/--mice until 21 days. Conclusions: Our study suggests a cardioprotective mechanism of CB2 receptor being associated with modulation of inflammatory response and myocardial remodeling during cardiac adaptation to pressure overload in a murine model of transverse aortic constriction.
Intraperitoneal Urine Leak in a Patient With a Renal Transplant on Tc-99m MAG3 Imaging
Authors: MAURICE GOODEAR, LINDSAY BARRATT, ALLAN WYCHERLEY
Journal: Clinical Nuclear Medicine (1998)

Although urine leaks are common after renal transplantation, these are usually obvious as external leakage through the surgical wound or drain or as the development of an extraperitoneal urinoma. A communication, with urine leakage, from a transplanted urinary tract to the peritoneal cavity is very uncommon. This case demonstrates the value of radionuclide renal imaging in demonstrating such an abnormality.
Immune cell populations in cutaneous delayed-type hypersensitivity.
Authors: J L Platt, B W Grant, A A Eddy, A F Michael
Journal: The Journal of Experimental Medicine (1983)

Delayed-type hypersensitivity (DTH) is a prototypic T lymphocyte-mediated response to antigenic challenge. In this study, mononuclear cells infiltrating the skin during cutaneous response to tuberculin in presensitized human subjects (responders) and nonimmune controls were identified using monoclonal antibodies by indirect immunofluorescence. In both responders and controls the infiltrate consisted mainly of T lymphocytes (T11+ and OKT3+) and monocytes (OKM1+, 63D3+, Mo2+) which initially accumulated in proximity to small blood vessels and later infiltrated the interstitial dermis and epidermis. More T lymphocytes reacted with OKT4 than with OKT8. 6 h after tuberculin the ratio of OKT4/OKT8 in tissue from responders exceeded that in blood, whereas in tissues studied at 15-48 h and in all control tissues those ratios in blood and tissue were similar. Evidence of T lymphocyte activation was sought using monoclonal antibodies anti-Tac, OKT9, and OKT10. In responders but not in controls the proportion of infiltrating cells reactive with these antibodies increased during the course of DTH. The presence of activated T lymphocytes in tissue was not associated with a comparable increase in peripheral blood cell populations identified by anti-Tac and OKT10. Studies using anti-B1, Leu-7, and anti-IgD/IgM revealed comparatively few reactive cells. Dual-labeling studies demonstrated that most Leu-7--reactive cells also bound T11 while fewer bound OKM1 or OKT8 and that cells reactive with OKIa1 and T11 constituted largely nonoverlapping populations. Specific patterns of reactivity were not observed when tissues were stained with anti-human C3, or poly C9-MA, a monoclonal antibody reactive with a neoantigen on polymerized C9 of the membrane attack complex of complement. The number of epidermal Langerhans cells identified by OKT6 was similar in responders and controls. Thus, the cutaneous response to tuberculin in sensitized individuals is characterized by early enrichment of the OKT4 subpopulation of T lymphocytes in tissue infiltrates and subsequent (15-48 h) evidence of T lymphocyte activation.
The New Frontier of Reproductive Age
Authors: Martin M. Quigley
Journal: JAMA (1992)

A female infant is born with a limited complement of ovarian oocytes. These oocytes are either ovulated or undergo atresia until menopause occurs when the complement of oocytes is exhausted. Although the average age for menopause in the United States is 51 years, menopause is generally preceded by a decade or more of declining reproductive capability, manifested by decreased cycle fecundity and increased rate of pregnancy loss. This decline is usually attributed to "aging" of the oocytes. While the Bible mentions pregnancy at advanced age,<sup>1</sup>it is only relatively recently, with the combination of in vitro fertilization (IVF) and oocyte donation, that the means exist to establish pregnancies in women who would normally conceive infrequently, if at all.<sup>2</sup> There are certainly legal, ethical, and pragmatic concerns associated with the use of donated oocytes in general. However, these concerns are limited when donated oocytes are used to establish pregnancies
Abstract A92: Killing quiescent cancer cells in vitro and in vivo with tumor targeting <i>Salmonella typhimurium</i> A1-R
Authors: Shuya Yano, Yong Zhang, Fuminari Uehara, Yukihiko Hiroshima, Shinji Miwa, Robert M. Hoffman, Ming Zhao
Journal: Cancer Research (2013)

Abstract Quiescent cancer cells are resistant to cytotoxic agents which target only proliferating cancer cells. Cancer cells were imaged to indicate the cell-cycle phase of each cancer cell in real time in solid tumors growing in vivo as well for cancer cells as in vitro using a fluorescence ubiquitination cell cycle indicator (FUCCI). With FUCCI, quiescent cancer cells express mKusabira-Orange fluorescent protein (red) and proliferating cells express mAzami-Green fluorescent protein (green). FUCCI-labeled cancer cells in monolayer culture and tumor spheres were treated with Salmonella typhimurium A1-R. Time-lapse confocal imaging showed that A1-R encircled and invaded quiescent cancer cells in monlayer culture, thereby eliminating them. Cancer cells in tumor spheres in serum-free culture become and remain quiescent. A1-R infected and killed quiescent cancer cells in tumor spheres. In contrast, cytotoxic agents did not kill quiescent cancer cells in tumor spheres. A1-R infection of FUCCI-expressing subcutaneous tumors growing in nude mice resulted in killing quiescent cancer cells resistant to cytotoxic agents. This study demonstrates that A1-R can kill quiescent cancer cells and suggest a new therapeutic paradigm potentially more effective than current therapy of cancer. Citation Format: Shuya Yano, Yong Zhang, Fuminari Uehara, Yukihiko Hiroshima, Shinji Miwa, Robert M. Hoffman, Ming Zhao. Killing quiescent cancer cells in vitro and in vivo with tumor targeting Salmonella typhimurium A1-R. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A92.
Does Change Imply Betterness?
Authors: H. Close Hesseltine
Journal: JAMA (1961)

THE ADDRESSES of the chairmen of the Section on Obstetrics and Gynecology of the American Medical Association have varied greatly in content and purpose. They have been literary, historic, scientific, and philosophic. This presentation intends to provoke questions and to stimulate ideation on some subjects of major concern to those practicing obstetrics and gynecology, and particularly on the implications and complications incidental to changes.  Definitions  It may facilitate one's thoughts to recall the meaning of the word  and also the word betterness. According to Webster's New Collegiate Dictionary , change means: 1. To alter by substituting something else for, or by giving up for something else; to put or take another or others in place of. 2. To make different; to convert. 3. To exchange. 4. To be altered or to vary. 5. To shift. The synonyms for  are alter, vary, and modify.  Change may be made because of
Ventricular Performance after Angiocardiography
Authors: SHAHBUDIN H. RAHIMTOOLA, JOHN P. DUFFY, H. J. C. SWAN
Journal: Circulation (1967)

Ventricular performance was assessed before and after angiocardiography in 22 patients with normal left ventricle, mitral stenosis, aortic stenosis, and myocardial disease. The increased circulating blood volume known to occur after angiocardiography is a determinant of the increased ventricular pre-load. The after-load is unchanged. Patients with normal left ventricle and some patients with valve stenosis responded by an increase in the work performed and some had only a minimal or no increase. A group of patients with serious heart disease performed less work. If the ventricular response can be considered on the basis of the Frank-Starling principle, then the abnormal response of such patients is due to an altered length-tension relationship.
Phenylbutazone and chromosomal damage.
Authors: S Walker, A Price Evans, P.A Benn, T.R Littler, L.D Halliday
Journal: Annals of the Rheumatic Diseases (1975)

Investigation of 44 paired test and control patients, all suffering from rheumatoid arthritis, following exposure to phenylbutazone (PBZ) and/or oxyphenbutazone (OPB), suggests that there is no significant increase in the level of chromosomal damage in lymphocytes. The control subjects comprised two series, one previously exposed to PBZ and/or OPB, but not for at least 1-5 years, and the other never exposed to PBZ or OPB. No significant difference in the level of chromosome damage was found between patients never exposed, previously exposed, or now receiving PBZ and/or OPB.
The Diagnostic Significance of Haematuria
Authors: R. Saundby
Journal: BMJ (1887)

when cultivated and inoculated in healthy animals, is capable of settimg up a septic inflammation.Indeed, the post-mortern appear- ances observed by Dr. Klein point iu my mind only to septic com- plication, which may equally-occur in cow-pox, in acarlatina, and in other febrile diseases.I think that the explanation of this micro- coccus being found occasionally in sc*rlatina is that in severe cases, with ulcerated throat, the blood is unable to cope with the invasion of micrococci from the surface lesion.If this be so, the opinion which I wrote early in 1886,4 concerning the micrococci which had been described in measles, applies also to this micrococcus, namely, that in this and in many other cases I on:ly described these organ- isms as distinct species "from their association with particular diseases, not because they are believed to be causally related, fol there is very little evidence in favour of that belief as yet, but purely for convenience of reference.In many cases they are probably onlv septic organisms which have found a pabulum in dead tissue, others appear to be identical with organisms which have been found in pus."Conclusions.-As the practical outcome of this research, I would strongly urge that prompt measures be.enforced for isolating diseased animals and preventing the spread of the disease through the herd.And as the milk is liable to be contaminated with blood, pus, and dis- charges from the teats, I consider that it would only be consistent with the most elementary rules of sanitation that only the milk ob- tained from the healthy cows in the herd should be seut into the market.Such measures, I trust, will lead to the alleviation of much suffering in the cows, insure greater cleanliness in the milk, and provide another source of vaccine for public use. 4Manual ofBacteriology, p. 291.
Overprescribing iron tablets to elderly people in Sweden.
Authors: P Reizenstein, G Ljunggren, B Smedby, I Agenas, M Penchansky
Journal: BMJ (1979)

Iron should not be prescribed to middle-aged men or older women with anaemia unless the possibility that the iron deficiency is caused by a gastrointestinal tumour has been considered. Thus the prescribing of iron to elderly people was investigated by studying four different prescription statistics and by reviewing records. Over one in 10 women aged over 65 were prescribed iron tablets. Men and women in the oldest age groups were prescribed iron most frequently. The reasons for prescribing iron were examined at a rural health centre. Out of 327 records of patients who were prescribed iron during 1975, 157 were randomly selected and reviewed. Only 18 out of 48 (38%) patients aged 45-75 (men) and 55-75 (women) and 29 out of 109 (27%) aged over 75 years had probable or possible iron-deficiency anaemia as established from the records. Only nine (19%) of the younger patients had a plausible reason for the anaemia other than a bleeding tumour. Ten (9%) of the older patients were considered to be inoperable cases. Thus, according to the records, only 18 (17%) of the patients over 75 years and nine (19%) of those in the younger age group have been prescribed iron. About 70% of all the patients were considered not to have iron deficiency; 7% had had iron deficiency previously, and 20% probably had anaemia as a result of chronic disease; for 43% no real reason for the iron prescription could be found in the record. Thus it is concluded that iron is overprescribed in Sweden, particularly for elderly people. It should not be prescribed until the possibility of a bleeding gastrointestinal tumour has been excluded.
High Residual Platelet Reactivity After Clopidogrel Loading and Long-Term Clinical Outcome After Drug-Eluting Stenting for Unprotected Left Main Coronary Disease
Authors: Angela Migliorini, Renato Valenti, Rossella Marcucci, Guido Parodi, Gabriele Giuliani, Piergiovanni Buonamici, Giampaolo Cerisano, Nazario Carrabba, Gian Franco Gensini, Rosanna Abbate, David Antoniucci
Journal: Circulation (2009)

No data exist about the impact of high residual platelet reactivity (HRPR) after clopidogrel loading on long-term clinical outcome in patients undergoing drug-eluting stent (DES) implantation for unprotected left main disease (ULMD).Consecutive patients who underwent percutaneous coronary intervention for ULMD had prospective platelet reactivity assessment by light transmittance aggregometry after a loading dose of 600 mg of clopidogrel. The primary end point of the study was cardiac mortality, and the secondary end point was stent thrombosis. From January 2005 to September 2008, 215 consecutive patients were treated with DES for ULMD. The incidence of HRPR after clopidogrel loading was 18.6%. The median follow-up was 19.3 months. The overall estimated 1-, 2- and 3-year cardiac mortality rate was 3.9+/-1.3%, 7.5+/-2.2%, and 12.2+/-3.4%, respectively. The 3-year cardiac mortality rate was 8.0+/-3.1% in the low residual platelet reactivity (LRPR) group and 28.3+/-10.4% in the HRPR group (P=0.005). The 3-year stent thrombosis rate was 4.2+/-1.8% in the low residual platelet reactivity group and 16.0+/-7.3% in the HRPR group (P=0.021). By forward stepwise regression analysis, HRPR after clopidogrel loading was the only independent predictor of cardiac death (hazard ratio, 3.82; 95% confidence interval,1.38 to 10.54; P=0.010) and stent thrombosis (hazard ratio, 3.69; 95% confidence interval, 1.12 to 12.09; P=0.031).HRPR after 600-mg clopidogrel loading is a strong marker of increased risk of cardiac death and DES thrombosis in patients receiving DES stenting for ULMD. Routine assessment of in vitro residual platelet reactivity after clopidogrel loading in patients with ULMD potentially suitable for DES-supported percutaneous coronary intervention should be considered to guide patient care decisions.