tbuckley/cabot-search huggingface dataset:
THE “BLACK HOLE” SIGN OF LEFT VENTRICULAR ANEURYSM IN Tl-201 SPECT IMAGES
Authors: A. C. Civelek, I. Shafique, J. Weiss, K. Durski, J. Brinker, M. Clausen, C. Szeles, H. N. Wagner
Journal: Clinical Nuclear Medicine (1988)

Fifty-three of 83 patients with transmural perfusion defects had a “black hole” within the left ventricle on Tl-201 SPECT images. A “black hole” was defined as a focal, oval area of no activity within the left ventricular cavity adjacent to the transmural perfusion defect. 30 patients had only transmural perfusion defects with no “black hole”. Transmural defect is defined as an area of decreased perfusion with activity equal to or less than background. All had contrast ventriculography and/or echocardiography or gated blood pool studies. Fifty out of 53 patients with a “black hole”, and one out of 30 patients with only a transmural defect had left ventricular aneurysm. Of these 50 true positives, 13 had parallel, 10 had converging and 27 had a diverging configuration of the left ventricle walls towards the apex. In the three false positives two had parallel and one had converging left ventricle walls. The criterion of a “black hole” for the diagnosis of left ventricular aneurysm in patients with transmural myocardial perfusion defect had a 98% sensitivity, 91% specificity, 95% accuracy and 94% predictive value. Combining the criterion of diverging configuration of left ventricle walls with transmural perfusion defect and a “black hole” increased the predictive value for left ventricular aneurysm to 100%. Thus the “black hole” sign in Tl-201 SPECT images is highly accurate in the diagnosis of left ventricular aneurysm.
Making Boxing Safer
Authors: Robert Ludwig
Journal: JAMA (1986)

BOXING is a dangerous sport. There is always a risk of brain damage. Professional boxing has been banned in Sweden since 1969. Medical supervision of amateur boxing is very strict and now well accepted. Special rules and restrictions to protect the boxer's health have now been practiced for more than ten years. As a consequence of this, there have been fewer knockouts (last season only 1%) and no brain damage has been detected. There are 136 boxing clubs in Sweden with 1,080 active boxers. Only five currently active boxers have had more than 100 matches. No boxer is more than 30 years old, and none has been knocked out more than twice. No actual boxing is allowed before the age of 15 years. Between 10 and 15 years of age, only technical training is permitted. In competition, points are counted for different technical details. In this age range, a boxer
Miliary Appearances in the Lungs in Mitral Stenosis
Authors: H. G. Nelson
Journal: BMJ (1947)

MEDCALBIRA 587 once more to swayback, I have ascertained that the soil in the Peak district where swayback is prevalent is heavily charged with lead.Is it possible that the present outbreak of infantile paralysis has a copper displacement factor in its aetiology?One mineral has been used to an extraordinary extent during the war years and since.I refer to tin.Aluminium cooking vessels were difficult to get during the war years, but since the shops have been flooded with them.Might I suggest that in each case of infantile paralysis the urine should be tested for traces of tin and aluminium ?-I am, etc., Kenwood, Chesterfield.
Nosocomial Infection, the Deficit Reduction Act, and Incentives for Hospitals
Authors: Nicholas Graves
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metastatic Follicular Carcinoma of the Thyroid With Tumor Thrombus in the Superior Vena Cava and Right Brachiocephalic and Internal Jugular Veins
Authors: Madhavi Tripathi, Rajnish Sharma, Abhinav Jaimini, Namita Singh, Sanjiv K. Saw, Anil K. Mishra, Anupam Mondal
Journal: Clinical Nuclear Medicine (2008)

A 48-year-old woman who had undergone subtotal thyroidectomy with right modified neck dissection underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) for assessing the extent of disease postoperatively (restaging). Biopsy was reported as follicular carcinoma thyroid. Abnormal linear FDG uptake was seen extending along the entire extent from the superior vena cava into the right brachiocephalic vein (RBCV), and up to the right internal jugular vein in the neck. An FDG-avid metastatic lymph node mass was seen in the right paratracheal location, which was infiltrating into the RBCV. CT angiography further confirmed invasion of this mass into the RBCV with extension of tumor thrombus into the superior vena cava not reaching the right atrium. This case shows that it is possible for metastatic follicular carcinoma thyroid to invade into great veins, which can be well depicted on FDG PET-CT.
Eruptive naevi: report of two cases, with enzyme histochemical, light and electron microscopical findings
Authors: R.A.J. EADY, J.J.H. GILKES, E. WILSON JONES
Journal: British Journal of Dermatology (1977)

The cases of two young adults with widespread multiple eruptive naevi are described. In the first patient, more than 100 lesions appeared during a period of 6 months. Young lesions were small fleshcoloured telangiectatic papules; older lesions were larger and verrucose with histological features of cellular naevi. In the second patient, a great number of lentigines developed in the course of 2 years. Light and electron microscopy showed that giant melanosomes were present within the lesions. The plasma level of β‐MSH‐like immuno‐reactivity was normal.
New law bans selling of products with unjustified health claims
Authors: Rory Watson
Journal: BMJ (2008)

Consumers in the United Kingdom are to receive stronger legal safeguards against products that claim, without any identifiable scientific evidence, to provide physical and mental health benefits such as tackling obesity or depression.

The protection will be provided by the consumer protection regulations that come into force on 26 May, which implement new pan-European rules on unfair commercial practices.

The scope of the legislation is deliberately wide and is the biggest shake up in consumer law for decades. It targets any unfair selling to consumers by any business. It is designed to …
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells
Authors: LiQi Li, Raja Jothi, Kairong Cui, Jan Y Lee, Tsadok Cohen, Marat Gorivodsky, Itai Tzchori, Yangu Zhao, Sandra M Hayes, Emery H Bresnick, Keji Zhao, Heiner Westphal, Paul E Love
Journal: Nature Immunology (2010)
Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload.
Authors: C B Porter, R A Walsh, F R Badke, R A O'Rourke
Journal: Circulation (1983)

To compare the hemodynamic effects of a calcium-channel blocker with those of a conventional vasodilator in the awake preinstrumented dog, diltiazem and nitroprusside were administered in equihypotensive infusions before (decrease in mean aortic pressure by 10%; p less than .001, n = 6) and after (decrease in mean aortic pressure by 12%; p less than .001) chronic volume overload (CVO) produced by an infrarenal aortocaval fistula. Diltiazem had no effect on preload either before or after CVO. The maximal rate of change in left ventricular pressure (dP/dtmax) was unaffected by diltiazem before the aortocaval fistula (decrease in dP/dtmax by 6%; p = NS) but was significantly reduced by calcium-channel blockade after CVO (decrease in dP/dtmax by 22%; p less than .001). By contrast, at matched aortic pressures nitroprusside significantly reduced left ventricular end-diastolic dimension (LVEDD) and pressure (LVEDP) in the same animals before (decrease in LVEDD by 10%, p less than .05; decrease in LVEDP by 7 +/- 2 mm Hg, p less than .001) and after CVO (decrease in LVEDD by 7%, p less than .05; decrease in LVEDP by 5 +/- 2 mm Hg, p less than .001) without altering dP/dtmax. We conclude that the calcium entry blocker diltiazem, unlike conventional vasodilators, may depress left ventricular function in CVO by direct negative inotropic properties in amounts that are without myocardial depressant effects in the presence of normal left ventricular performance.
Aristolochic Acid, an Herbal Carcinogen, Sold on the Web after FDA Alert
Authors: Lois Swirsky Gold, Thomas H. Slone
Journal: New England Journal of Medicine (2003)

this virus is very rarely a cause of hepatomegaly, hyperbilirubinemia, or thrombocytopenia, 2 all of which were prominent presenting manifestations in the case under discussion.
Paget's disease of bone treated with a five day course of oral tiludronate.
Authors: J Y Reginster, M P Lecart, R Deroisy, D Ethgen, B Zegels, P Franchimont
Journal: Annals of the Rheumatic Diseases (1993)

Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have only been seen at doses much higher than those required to decrease osteoclastic activity, it could be given at high doses over a short period of time. Eighteen patients with Paget's disease of bone were randomly allocated to three therapeutic groups receiving respectively 600, 800, and 1200 mg/day tiludronate for five days. Serum alkaline phosphatase activity and the urinary hydroxyproline/creatinine ratio were quickly and drastically reduced in all three groups. A significant reduction of serum alkaline phosphatases and the hydroxyproline/creatinine ratio was still present six months after the five day therapeutic course, reflecting a sustained activity of tiludronate even after stopping treatment. Dose dependent short and long term reductions of bone turnover rate were observed. Biochemical assessment of haematological, renal, or hepatic tolerance did not show any toxicity of tiludronate. Fifty per cent of patients treated by a dose of 1200 mg/day reported gastrointestinal disturbances, however, making this dosage unsuitable for clinical practice.
CD11b is a therapy resistance– and minimal residual disease–specific marker in precursor B-cell acute lymphoblastic leukemia
Authors: Peter Rhein, Rita Mitlohner, Giuseppe Basso, Giuseppe Gaipa, Michael N. Dworzak, Renate Kirschner-Schwabe, Christian Hagemeier, Martin Stanulla, Martin Schrappe, Wolf-Dieter Ludwig, Leonid Karawajew, Richard Ratei
Journal: Blood (2010)
Particle assembly incorporating a VP22–BH3 fusion protein, facilitating intracellular delivery, regulated release, and apoptosis
Authors: N.D. Brewis, A. Phelan, N. Normand, E. Choolun, P. O'Hare
Journal: Molecular Therapy (2003)

Previously we showed that addition of purified VP22, a structural protein of herpes simplex virus, to short oligonucleotides (ODN) induced the spontaneous assembly of novel particles incorporating both protein and ODN. These particles were not toxic, entered cells, and resided stably in the cytoplasm. Surprisingly the particles could be activated by light in a regulated synchronous manner to release ODN and protein to the cell cytosol and nuclei. Here we construct a fusion protein containing a short peptide from the proapoptotic BH3 domain family member Bak. The BH3-VP22 protein was recruited into particles that entered cells and remained stable in the cytoplasm without toxicity. Light activation rapidly disrupted the particles, a process captured in living cells by time-lapse microscopy, and this synchronized regulated release resulted in subsequent cell death by apoptosis. In control experiments, particles containing a mutant BH3 peptide, although indistinguishable in cell uptake and regulated release, showed no apoptotic effect. Regulated release of VP22-based particles may find application in mechanistic analysis of apoptotic pathways, in cell-based screening assays both of peptides and of oligonucleotides, or as therapeutic agents incorporating specific additional components.
TOXIC PSYCHOSIS DUE TO IODOFORM
Authors: ALAN L. MORGENSTERN
Journal: American Journal of Psychiatry (1963)

Toxic psychosis due to iodoform hypersensitivity is uncommon and is rarely recognized. It generally occurs when the drug is painted on large surfaces which allow its absorption or when iodoform gauze is used as a packing in cavities. This case showed the typical mental symptoms of depression followed by delirium. The treatment is removal of the drug and general supportive measures until recovery is effected.
Primary Lymphosarcoma of the Small Intestine
Authors: J. S. Cornes
Journal: BMJ (1961)

CHRONIC PULMONARY TUBERCULOSISMEDICAL JOUSRNA 13etailed studies suggest that the relapse in these cases could be largely attributed to the fact that on release from close supervision as in-patients both these persons failed to persevere with the chemotherapy and with the more general measures required for the complete arrest of their pulmonary lesions.Further periods of hospital treatment have been provided, using other chemotherapy, but to date the sputa have remained persistently positive.We can therefore still maintain the conclusion stated above, that ethionamide is a valuable antituberculous drug.
Immunohistochemical demonstration of acetaldehyde-modified epitopes in human liver after alcohol consumption.
Authors: O Niemelä, T Juvonen, S Parkkila
Journal: Journal of Clinical Investigation (1991)

Acetaldehyde, the toxic product of ethanol metabolism in the liver, covalently binds to a variety of proteins. Recent studies indicate that such binding can stimulate the production of antibodies against the acetaldehyde adducts. We raised rabbit antibodies which recognized various protein-acetaldehyde conjugates but not the corresponding control proteins. Such antibodies were used in immunohistochemical studies to find out whether acetaldehyde-generated epitopes can be detected from liver specimens of 13 human subjects with different degrees of alcohol consumption. While the specimens obtained from alcohol abusers (n = 4) and alcoholics (n = 3) exhibited marked positive staining for acetaldehyde adducts inside the hepatocytes in a granular uneven pattern, the control samples (n = 6) were almost devoid of immunoreactivity. In the alcohol abusers with an early stage of alcohol-induced liver damage, staining was detected exclusively around the central veins. The data indicate that intracellular acetaldehyde adducts occur in the centrilobular region of the liver of individuals consuming excessive amounts of alcohol. Immunohistochemical detection of such adducts may prove to be of value in the early identification of alcohol abuse and in elucidating the mechanisms of alcohol-induced organ damage.
Early Bactericidal Activity and Sterilizing Activity of Ciprofloxacin in Pulmonary Tuberculosis: From the Authors
Authors: S. H. Gillespie, N. Kennedy
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Early Bactericidal Activity and Sterilizing Activity of Ciprofloxacin in Pulmonary Tuberculosis: From the Authors." American Journal of Respiratory and Critical Care Medicine, 151(3_pt_1), pp. 921–922
Failure of suicide prevention measures at Risley.
Authors: E. Martin
Journal: BMJ (1988)

in response to hormone deficiency and replace- ment.This is shown by our longitudinal data and those of others.3The menopause is the most important factor in determining bone loss at the femoral neck.4Like Dr Selby and colleagues we do not know whether minor effects seen in cortical bone in the forearm or metacarpal have any relevance to the femoral neck.Their misquotation of a study of osteoporotic women in which no significant effect of calcium on cortical area was found does not add weight to their argument.Nor does Dr Gillespie's misinterpreta- tion of our table II, where negative percentage change values represent bone loss.There are certain times during life when extra calcium intake is required physiologically.These include growth, pregnancy, and lactation; but not the postmenopause.
The Changed Nature of Scut: An Absence at the Bedside
Authors: Jonathan M. Green
Journal: Annals of Internal Medicine (2007)

On Being a Doctor16 October 2007The Changed Nature of Scut: An Absence at the BedsideJonathan M. Green, MDJonathan M. Green, MDFrom Washington University School of Medicine, St. Louis, MO 63110.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-8-200710160-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It was a late night on call when my pager went off. I called the floor. The nurse informed me that my patient, Mr. McDonough, had a fever. I grumbled and trudged to the ward to do one of the numerous fever work-ups of my internship.“Hi, Mr. McDonough, I hear you have a bit of a temperature,” I said as I entered the room. He looked at me, tried to smile, and agreed. He was sweating, and his blanket was tossed from his bed. I looked for a vein to draw blood and noted his clammy skin. His pulse ... Author, Article, and Disclosure InformationAffiliations: From Washington University School of Medicine, St. Louis, MO 63110.Corresponding Author: Jonathan M. Green, MD, Washington University School of Medicine, 660 South Euclid Avenue, Box 8052, St. Louis, MO 63110; e-mail, [email protected]wustl.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byResigned professionalism? Non-acute inpatients and resident educationClinical Triggers: An Alternative to a Rapid Response Team 16 October 2007Volume 147, Issue 8Page: 588KeywordsBloodFeversHeart rateIntensive care unitsNursesShockSputumTechniciansThoraxUrine ePublished: 16 October 2007 Issue Published: 16 October 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Treatment of psoriasis with alefacept in patients with hepatitis C infection: a report of two cases
Authors: D. Thaci, S. Patzold, R. Kaufmann, W-H. Boehncke
Journal: British Journal of Dermatology (2005)

Journal Article Treatment of psoriasis with alefacept in patients with hepatitis C infection: a report of two cases Get access D. Thaçi, D. Thaçi Department of Dermatology, Johann Wolfgang Goethe‐University, Theodor‐Stern‐Kai 7, D‐60590 Frankfurt am Main, Germany Search for other works by this author on: Oxford Academic Google Scholar S. Pätzold, S. Pätzold Department of Dermatology, Johann Wolfgang Goethe‐University, Theodor‐Stern‐Kai 7, D‐60590 Frankfurt am Main, Germany Search for other works by this author on: Oxford Academic Google Scholar R. Kaufmann, R. Kaufmann Department of Dermatology, Johann Wolfgang Goethe‐University, Theodor‐Stern‐Kai 7, D‐60590 Frankfurt am Main, Germany Search for other works by this author on: Oxford Academic Google Scholar W‐H. Boehncke W‐H. Boehncke Department of Dermatology, Johann Wolfgang Goethe‐University, Theodor‐Stern‐Kai 7, D‐60590 Frankfurt am Main, Germany Wolf‐Henning Boehncke. E‐mail: boehncke@em.uni‐frankfurt.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 5, 1 May 2005, Pages 1048–1050, https://doi.org/10.1111/j.1365-2133.2005.06423.x Published: 01 May 2005 Article history Accepted: 16 September 2004 Published: 01 May 2005
Fewer law firms to handle NHS negligence cases
Authors: C. Dyer
Journal: BMJ (1998)

Dozens of law firms with years of experience defending NHS trusts and health authorities against large medical negligence claims will no longer be allowed to handle such cases, the NHS Litigation Authority has decided.

Trusts have been able to choose their own firms until now, and the casework has been spread among more than 90 law firms. But from 1 April trusts will …
Where have all the nurses gone?
Authors: P. J B Hubner
Journal: BMJ (1980)

maximum part-time contracts" he states that "'many regions regard travel, administration, and emergency duties as representing two NHDs weekly for the generality of maximum part-time consultants."This seems to indicate that in those many regions maximum part- time consultants will be contracted to work for 28 hours in order to qualify for 10/1 lths of the whole-time salary.It would be helpful if Mr Bolt could com-
RU-486: Hoechst-Roussel (US), Hoechst AG, Roussel Uclaf SA, and Hoechst-Roussel Pharmaceuticals Inc
Authors: Daniel J. Stone
Journal: JAMA (1991)

<h3>To the Editor. —</h3> Regelson et al<sup>1</sup>did a fine job of summarizing the clinical promise of the progesterone antagonist RU-486 in their Commentary. Although the article concentrated on the less-publicized applications of the drug, the authors appropriately observed that the availability of RU-486 in areas where abortion remains a legal option "must be decided by clinical data and not on the basis of economic threats." The alternative would be to allow abortion opponents to maximize the morbidity and mortality of the procedure in order to deter some women from choosing abortion. As long as termination of pregnancy is legal, physicians have a responsibility to optimize its safety and to prevent the lives and health of women patients from being used as a political football. As Regerlson et al suggest, the fact that the care of cancer victims and others who could potentially benefit from the drug is being
Does a Low Level of Expression of HLA Molecules Engender Autoimmunity?
Authors: D. H. Raulet, O. Schillaci, F. Scopinaro, L. R. Abramson, S. Retsas, D. N. Krag, Jr Moffat, T. Ashikaga, K. M. McMasters, M. J. Edwards, Merrick I Ross
Journal: New England Journal of Medicine (1999)

The immune system can summon a variety of defenses against invaders from the outside. Among these deterrents are three types of killer lymphocytes that attack and lyse cellular targets. One type consists of cytotoxic, or CD8, T cells with α/β antigen receptors that interact with the HLA class I glycoproteins on nearly all cells. These HLA molecules bind to peptides derived from intracellular antigens, such as viral proteins, and display them on the cell surface. Binding of the α/β antigen receptor to complexes of HLA class I molecules and peptide fragments of an invading virus induces the T lymphocyte to . . .
Rectal quinine for malaria: Authors' reply
Authors: H Barennes, E Pussard
Journal: BMJ (2006)

EDITOR—Hypoglycaemia resulting from quinine induced hyperinsulinaemia is indeed a side effect of quinine treatment. We assumed that the risk of hypoglycaemia is similar after rectal or intramuscular quinine because rectal administration of doses of 16 or 20 mg/kg …