Multiple Carcinomata Following Ingestion of Medicinal Arsenic
Authors: STANLEY MINKOWITZ
Journal: Annals of Internal Medicine (1964)

Case Studies1 August 1964Multiple Carcinomata Following Ingestion of Medicinal ArsenicSTANLEY MINKOWITZ, M.D.STANLEY MINKOWITZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-296 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptArsenical preparations were first related etiologically to epidermoid carcinomata when Jonathan Hutchinson incriminated them in 1887 (1-8). Notably multicentric in origin these malignancies are generally preceded and accompanied by disseminated keratoses and precanceroses, and tend to appear in a younger population than do similar nonarsenical forms of cancer (4, 5, 8, 9). Like late radiation neoplasia, a variable, rather long latent period is frequently observed between the time of exposure to the implicated arsenical and the clinical appearance of the neoplasm. The purpose of this paper is to re-emphasize that arsenical carcinomata are potentially extremely malignant lesions and that endless,...References1. HUTCHINSON J: Arsenic cancer. Brit. Med. J. 2: 1280, 1887. Google Scholar2. ARHELGERKREMEN SWAJ: Arsenical epitheliomas of medicinal origin. Surgery 30: 977, 1951. MedlineGoogle Scholar3. HILLFANNING ABEL: Studies in the incidence of cancer in a factory handling inorganic compounds of arsenic. Brit. J. Industr. Med. 5: 2, 1948. Google Scholar4. NEUBAUER O: Arsenical cancer: a review. Brit. J. Cancer 1: 192, 1957. CrossrefGoogle Scholar5. NEUMANSCHWANK ER: Multiple malignant and benign epidermal and dermal tumors following arsenic. Acta Dermatovener. 40: 400, 1960. MedlineGoogle Scholar6. ROSSET ML: Arsenical keratosis associated with carcinoma of internal organs. Canadian Med. Ass. J. 78: 416, 1958. MedlineGoogle Scholar7. ROTH F: The sequelae of chronic arsenic poisons in Moselle Vintners. German Med. Monthly 2: 172, 1957. 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Author, Article, and Disclosure InformationAffiliations: Brooklyn, New YorkFrom the Department of Pathology of the College of Medicine, State University of New York, Downstate Medical Center, and The Institute of Pathology, Kings County Hospital Medical Center, New York.Requests for reprints should be addressed to Stanley Minkowitz, M.D., Downstate Medical Center, State University of New York, 450 Clarkson Avenue, Brooklyn, New York 11203. 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