tbuckley/cabot-search huggingface dataset:
Controlled Electroencephalographic Investigation of Patients with Neurotic Excoriations
Authors: Kjeld Fruensgaard, Henry Nielsen, Anders Hjortsh&oslash;j
Journal: Psychotherapy and Psychosomatics (1980)

Because of the self-destructive character of neurotic excoriations (n.ex.), it is probable that relatively unmasked aggression plays a greater role than in 'normal' neurotics. In this investigation EEG abnormalities have been found for 51.9% of a group of 54 consecutive patients with n.ex. as against an abnormality frequency of 25% in a control group of neurotics without n.ex. The frequency of abnormalities in the n.ex. group is of the same level as for aggressive psychopaths, a finding which supports the above-mentioned hypothesis. In the majority of cases these abnormalities took the form of unspecific changes mainly showing bilateral theta activity. The basis of the registered left-sided preponderance of EEG abnormalities is discussed.
Acute Torsion of the Gall-bladder
Authors: A. H. Barber
Journal: BMJ (1939)

MEDICE J3oRRtALmay contintue for as long as for-tnight before the nex-t phase beconies manifest.The discharge now becomes progressively more muicoid, and gradually diminishes in amount until the ear is only moist.The argyrol is then omitted and the ear simply cleaned out daily, dried with spirit, and a little boric powder insufflated.
Lumbar epidural analgesia in labour: a 24-hour service provided by obstetricians.
Authors: A B Taylor, S H Abukhalil, M M El-Guindi, B Tharian, J A Watkins
Journal: BMJ (1977)

Of 309 consecutive cases of epidural analgesia provided by obstetricians, 250 set up by junior obstetric staff. Midwives managed the epidural analgesia and gave the top-up doses as part of their traditional role in providing pain relief in labour. This practice was thought to be influential in producing a high sponn epidural analgesic service can safely be provided by obstetricians in a small maternity hospital.
Children's height and weight in rural and urban populations in low-income and middle-income countries: a systematic analysis of population-representative data
Authors: Christopher J Paciorek, Gretchen A Stevens, Mariel M Finucane, Majid Ezzati
Journal: The Lancet Global Health (2013)

Urban living affects children's nutrition and growth, which are determinants of their survival, cognitive development, and lifelong health. Little is known about urban-rural differences in children's height and weight, and how these differences have changed over time. We aimed to investigate trends in children's height and weight in rural and urban settings in low-income and middle-income countries, and to assess changes in the urban-rural differentials in height and weight over time.
Rethinking<i>Roe v. Wade</i>: Defending the Abortion Right in the Face of Contemporary Opposition
Authors: Bertha Alvarez Manninen
Journal: The American Journal of Bioethics (2010)

In 2008, many states sought to pass Human Life Amendments, which would extend the definition of personhood to encompass newly fertilized eggs. If such an amendment were to pass, Roe v. Wade, as currently defended by the Supreme Court, may be repealed. Consequently, it is necessary to defend the right to an abortion in a manner that succeeds even if a Human Life Amendment successfully passes. J.J. Thomson's argument in "A Defense of Abortion" successfully achieves this. Her argument is especially strong when one considers that her central thesis—that one person's right to life does not entail the right to use another's person's body for continued sustenance—is pervasive in legal policies in the U.S.A.
Subtle spine abnormalities in patients with back pain: fracture vs. congenital anomaly.
Authors: D Resnick
Journal: Annals of the Rheumatic Diseases (1978)

Klebsiella pneumoniaeSir, We are grateful for the opportunity of replying to the letters of Drs Brewerton and Warren and Dr Eastmond, Professors Cooke, and Wright (Annals, 37, 298)
Innovative Program Offers HIV Therapy to Internally Displaced Persons in Uganda
Authors: Tracy Hampton
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Diagnosis of Thyroid Cancer
Authors: M. D. Staunton, W. P. Greening
Journal: BMJ (1973)

In a survey of 293 patients with carcinoma of the thyroid, a goitre or enlarged lymph nodes in the neck were the commonest symptoms and a mass confined to one lobe the commonest sign. Hardness of the mass was an important diagnostic feature, and at least two-thirds of the tumour could be recognized before operation. It is suggested that the preoperative evaluation of thyroid swellings should be classified as benign, cancer suspected, and cancer probable.
285Hyperosmolarity-enhanced cox-2 expression contributes to high glucose-induced microangiopathy
Authors: R Madonna, MA Teberino, FV Renna, YJ Geng, R De Caterina
Journal: Cardiovascular Research (2014)

Aim: Diabetic hyperglycemia increases plasma osmolarity, leading to adaptive cellular responses. Cycloxygenase-2 (COX-2) plays a role in angiogenesis and plaque stability. We tested whether glucose-induced hyperosmolarity promotes angiogenesis through activation of COX-2 expression. Methods: Human aortic endothelial cells (HAEC) and dermal microvascular endothelial cells (HMVEC) were incubated with 5.5 mmol/L glucose (normoglycemia), high glucose (HG, at 12.5, 25 and 45 mmol/L), or equimolar concentrations of the hyperosmolar control mannitol (HM). Results: Both HG and HM increased the expression of the water channel aquaporin-1 (AQP1) and of COX-2. HG and HM for 1 h increased the nuclear accumulation of Tonicity enhancer binding protein (TonEBP) and its binding to Tonicity enhancer element at electrophoretic mobility shift assay. HG and HM induced endothelial migration at a fluorimetric assay, and tubulization in Matrigel. Targeting the osmosignaling pathway with small interfering RNAs to AQP1 and to TonEBP both reverted the inducing effects of HG and HM on COX-2 expression, as well as angiogenic activities. Finally, compared with age- and sex-matched C57/BL6 control mice (N=5 wild type, WT), the retina of Ins2 Akita diabetic mice (N=5, male, 1 year-old mice) showed higher vascular density as visualized with CD31 staining (Figure, panel A-B; legend: ONL, outer nuclear layers; OPL, outer plexiform layers; INL, inner nuclear layers; IPL, inner plexiform layers), and increased expression of AQP1 and COX-2 (panel C-E) (** p<0.01 by ANOVA and t-test). Diabetic retinopathy
SV40 Oncoproteins Enhance Asbestos-Induced DNA Double-Strand Breaks and Abrogate Senescence in Murine Mesothelial Cells
Authors: Jodie R. Pietruska, Agnes B. Kane
Journal: Cancer Research (2007)

Abstract SV40 virus has emerged as a potential cofactor with asbestos in the development of diffuse malignant mesothelioma, but its precise role in the pathogenesis of this tumor is unclear. SV40 large T antigen is known to inactivate cellular proteins involved in DNA damage and senescence, including p53 and pRb. We hypothesize that SV40 oncoproteins will sensitize mesothelial cells to DNA damage induced by asbestos or chemotherapeutic agents. SV40 oncoprotein expression in murine mesothelial cell lines enhanced spontaneous and asbestos-induced double-strand breaks, indicated by γ-H2AX foci, and potentiated micronucleus formation. Mesothelial cells exposed to asbestos or bleomycin for 96 h acquired senescent-like morphology and displayed elevated senescence-associated β-galactosidase activity, reduced bromodeoxyuridine (BrdUrd) incorporation, and reduced colony formation. SV40 oncoprotein expression abrogated the senescent phenotype, and transfected cell lines showed an increase in both BrdUrd incorporation and colony formation after prolonged DNA damage. Murine mesothelial cell lines lacking wild-type p53 due to a point mutation or gene rearrangement also failed to senesce in response to asbestos or chemotherapeutic agents. In addition, stress-induced senescence in human mesothelial cell lines was impaired by SV40 oncoprotein expression (MeT-5A), p53 small interfering RNA, or spontaneous p53 mutation (REN). These studies suggest that exposure to DNA-damaging agents can induce senescence in both murine and human mesothelioma cell lines and suggest a major, although not exclusive, role for p53 in this response. SV40 virus may contribute to mesothelioma progression by impairing stress-induced senescence, in part through p53 inactivation, thereby favoring survival and proliferation of mesothelial cells that have sustained DNA damage. [Cancer Res 2007;67(8):3637–45]
Blood Pyruvate and a-Ketoglutarate in Normal and Diabetic Subjects
Authors: M. J. H. Smith, K. W. Taylor
Journal: BMJ (1956)

I am also grateful to Dr. R. C. Tudway, who has allowed me to use the facilities of the Radiotherapy Department of the United Bristol Hospitals and to the physicists at Bristol General Hospital for their ready co-operation.Miss J. A.
Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12
Authors: Shau-Ping Lin, Neil Youngson, Shuji Takada, Hervé Seitz, Wolf Reik, Martina Paulsen, Jerome Cavaille, Anne C Ferguson-Smith
Journal: Nature Genetics (2003)
Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides
Authors: Jingwei Li, Liang Feng, Li Fan, Yuan Zha, Liangran Guo, Qizhi Zhang, Jun Chen, Zhiqing Pang, Yuchen Wang, Xinguo Jiang, Victor C. Yang, Longping Wen
Journal: Biomaterials (2011)
Impact of Positive and Negative Lesion Site Remodeling on Clinical Outcomes
Authors: Shinji Inaba, Gary S. Mintz, Naim Z. Farhat, Jean Fajadet, Dariusz Dudek, Antonio Marzocchi, Barry Templin, Giora Weisz, Ke Xu, Bernard de Bruyne, Patrick W. Serruys, Gregg W. Stone, Akiko Maehara
Journal: JACC. Cardiovascular imaging (2014)
COMBINED PERPHENAZINE-AMITRIPTYLINE AS ADJUVANT THERAPY IN PSYCHIATRIC AFTERCARE
Authors: ELSE B. KRIS, DAVID GERST
Journal: American Journal of Psychiatry (1964)

An amitriptyline-perphenazine combination was used to treat the mixed anxiety, tension, and depression which may occur in patients being maintained on phenothiazines. Of 33 such patients seen regularly in a community aftercare clinic, 29 (88%) showed considerable or total remission of symptoms. Dizziness, nausea, and vomiting required discontinuing amitriptyline-perphenazine therapy in 3 patients. One patient complained of dry mouth. This drug combination may be of great help in the maintenance therapy of psychotic outpatients. Further study would seem to be warranted.
Carbenoxolone Sodium in the Treatment of Peptic Ulcer
Authors: John R. Lewis
Journal: JAMA (1974)

THE dates on which several new therapeutic agents were introduced in the United States and Great Britain have recently been compared by Wardell.<sup>1</sup>He also conducted a survey on the usage of these new drugs by British physicians, and the awareness of them by American physicians.<sup>2</sup> Among the drugs available in Great Britain but not in this country, carbenoxolone sodium is notable for two reasons: (1) the "lead" time that it has been available in Great Britain is among the longest of the drugs surveyed (ten years), and (2) it is recognized as "the only drug therapy that has been shown unequivocally to promote the healing of gastric ulcers."1 Several reviews of carbenoxolone have appeared in the foreign literature<sup>3-6</sup>but, with the exception of one report on the proceedings of a symposium,<sup>7</sup>only a brief summary of the drug's actions by Wolf<sup>8</sup>has been published
Two new approaches to the diagnosis of thyroid disorders
Authors: Z. Danilevicius
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P236 Superior lung function with once-daily QVA149 translates into improvements in patient-reported breathlessness compared with placebo and tiotropium in COPD patients: the BLAZE study
Authors: A D'Urzo, DA Mahler, M Decramer, H Worth, T White, VKT Alagappan, N Gallagher, H Chen, K Kulich, D Banerji
Journal: Thorax (2013)

<h3>Introduction</h3> QVA149, a novel once-daily inhaled dual bronchodilator combining a fixed dose of the long-acting β<sub>2</sub> agonist indacaterol and the long-acting muscarinic antagonist glycopyrronium, has demonstrated improvements in dyspnoea versus its mono-components (indacaterol and glycopyrronium), tiotropium, and salmeterol/fluticasone using the interviewer-based Transition Dyspnoea Index (TDI) questionnaire.<sup>1,2</sup> The BLAZE study evaluated the effect of once-daily QVA149 on patient-reported dyspnoea versus placebo and blinded tiotropium in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD). <h3>Methods</h3> This was a 6 week, multicentre, randomised, blinded, double-dummy, placebo-controlled, 3-period, cross-over study. Patients aged ≥40 years with moderate-to-severe COPD, post-bronchodilator forced expiratory volume in 1 second (FEV<sub>1</sub>) ≥30% and &lt;80% of the predicted normal, and post-bronchodilator FEV<sub>1</sub>/ forced vital capacity &lt;0.7 were randomised to receive QVA149 110/50 μg (via the Breezhaler<sup>®</sup> device) or placebo (via the Breezhaler®/ HandiHaler<sup>®</sup> device) or blinded tiotropium 18 μg (via the HandiHaler<sup>®</sup> device). The primary objective of the study was to evaluate the superiority of QVA149 versus placebo in the improvement of patient-reported dyspnoea as assessed by Self-Administered Computerised (SAC) version of the Baseline Dyspnoea Index (BDI)/TDI after 6 weeks of treatment. Other objectives included; standardised FEV<sub>1</sub> area under the curve from 0 to 4 hours post-dose (AUC<sub>0–4 h</sub>); rescue medication use; safety and tolerability. <h3>Results</h3> Of the 247 patients (mean age 62.8 years) randomised, 191 completed the study. The SAC TDI total score was significantly improved with QVA149 compared with placebo and tiotropium after 6 weeks (figure). FEV<sub>1</sub> AUC <sub>0–4 h</sub> was significantly higher for QVA149 versus placebo and tiotropium at Day 1 and Week 6 (all p &lt; 0.001). Rescue medication use was significantly lower with QVA149 versus placebo (p &lt; 0.001) and tiotropium (p = 0.002). Incidence rate of adverse events was similar across all the treatment groups (QVA 149: 35.0%; tiotropium: 35.5%; placebo: 39.4%). <h3>Conclusion</h3> The BLAZE study provides evidence that the improved lung function with QVA149 translates into greater relief of breathlessness and improved patient-reported outcomes. <h3>Reference</h3> Bateman <i>et al</i>. Eur Respir J. 2013 May 30. Vogelmeier <i>et al</i>. Lancet Respir Med. 2013; 1:51–60.
Autologous Bone Marrow Transplantation in Non-Hodgkin's Lymphoma
Authors: Saul A. Rosenberg
Journal: New England Journal of Medicine (1987)

IT is generally agreed that patients with intermediate-grade and high-grade non-Hodgkin's lymphomas who have a relapse after initial therapy have a grave prognosis. Despite attempts at secondary (often called "salvage") therapy with irradiation or chemotherapy or both, few patients can be expected to be cured of their recurrent disease.Among the experimental approaches to this clinical situation is bone marrow transplantation after maximal cytoreductive chemotherapy, usually with whole-body irradiation. The use of autologous bone marrow in the procedure has obvious advantages. It also has theoretical disadvantages. The chief advantage, of course, is avoidance of the serious problems of graft-versus-host disease . . .
Effects of Exercise Training on Left Ventricular Function and Peripheral Resistance in Patients With Chronic Heart Failure
Authors: Rainer Hambrecht
Journal: JAMA (2000)

Exercise training in patients with chronic heart failure improves work capacity by enhancing endothelial function and skeletal muscle aerobic metabolism, but effects on central hemodynamic function are not well established.To evaluate the effects of exercise training on left ventricular (LV) function and hemodynamic response to exercise in patients with stable chronic heart failure.Prospective randomized trial conducted in 1994-1999.University department of cardiology/outpatient clinic in Germany.Consecutive sample of 73 men aged 70 years or younger with chronic heart failure (with LV ejection fraction of approximately 0.27).Patients were randomly assigned to 2 weeks of in-hospital ergometer exercise for 10 minutes 4 to 6 times per day, followed by 6 months of home-based ergometer exercise training for 20 minutes per day at 70% of peak oxygen uptake (n=36) or to no intervention (control group; n=37).Ergospirometry with measurement of central hemodynamics by thermodilution at rest and during exercise; echocardiographic determination of LV diameters and volumes, at baseline and 6-month follow-up, for the exercise training vs control groups.After 6 months, patients in the exercise training group had statistically significant improvements compared with controls in New York Heart Association functional class, maximal ventilation, exercise time, and exercise capacity as well as decreased resting heart rate and increased stroke volume at rest. In the exercise training group, an increase from baseline to 6-month follow-up was observed in mean (SD) resting LV ejection fraction (0.30 [0.08] vs 0.35 [0.09]; P=.003). Mean (SD) total peripheral resistance (TPR) during peak exercise was reduced by 157 (306) dyne/s/cm(-5) in the exercise training group vs an increase of 43 (148) dyne/s/cm(-5) in the control group (P=.003), with a concomitant increase in mean (SD) stroke volume of 14 (22) mL vs 1 (19) mL in the control group (P=.03). There was a small but significant reduction in mean (SD) LV end diastolic diameter of 4 (6) mm vs an increase of 1 (4) mm in the control group (P<.001). Changes from baseline in resting TPR for both groups were correlated with changes in stroke volume (r=-0.76; P<.001) and in LV end diastolic diameter (r=0.45; P<.001).In patients with stable chronic heart failure, exercise training is associated with reduction of peripheral resistance and results in small but significant improvements in stroke volume and reduction in cardiomegaly. JAMA. 2000.
The Effect of Sodium Malate Combinations Upon Gastric Acidity
Authors: John C. Krantz, A. A. Silver, Bernard J. Hoffman
Journal: Annals of Internal Medicine (1931)

Article1 May 1931The Effect of Sodium Malate Combinations Upon Gastric AcidityJOHN C. KRANTZ JR., Ph.D., A. A. SILVER, M.D., BERNARD J. HOFFMANJOHN C. KRANTZ JR., Ph.D., A. A. SILVER, M.D., BERNARD J. HOFFMANAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-11-1441 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous communication to this journal, one of us (J.K.) (1) studied the metabolism of a certain sodium malate mixture when employed as a dietary substitute for sodium chloride. The mixture studied consisted of 85.5 per cent of disodium malate, 9 per cent of trisodium citrate, 5 per cent of triammonium citrate and 0.5 per cent of manganese bromide. In this work the administration of this mixture of salts in the form of a condiment was shown to influence the acid-base equilibrium of the urine in the direction of the alkaline side. The malic acid was apparently completely metabolized....Bibliography1 KRANTZ JC: Ann. Int. Med., 3 (1930): 826. LinkGoogle Scholar2 WEBSTERKOCH : Manual Physiol. Chem., University Press, Chicago. Google Scholar3 WILSON J: Ind. and Eng. Chem. 17 (1925): 74. CrossrefGoogle Scholar4 SHOHLKING ATJH: Bull. Johns Hopkins Hosp. 31 (1920): 158. Google Scholar5 GORTNER RA: Outlines of Biochemistry, Wiley and Sons, New York, 1929, p. 93. Google Scholar6 REHFUSS ME: J. Am. Med. Ass'n., 71 (1918): 1534. CrossrefGoogle Scholar7 VAN SLYKE DD: J. Biol. Chem., 52 (1922): 525. CrossrefGoogle Scholar8 KRANTZ JC: J. Am. Pharm. Ass'n. 18 (1929): 469. Google Scholar9 KRANTZ JC: J. Am. Pharm. Ass'n., 19 (1930): 366. Google Scholar10 KRANTZCARR JCCJ: J. Phys. Chem. 35 (1931): 756. CrossrefGoogle Scholar11 , APPLIED BIOCHEM., MORSE.: Saunders & Co., Philadelphia, 1927, p. 433. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOral Penicillin with Basic Aluminum Aminoacetate 1 May 1931Volume 4, Issue 11Page: 1441-1446KeywordsSaltsSodiumSodium chlorideUrine Issue Published: 1 May 1931 PDF DownloadLoading ...
Virus-specific interferon action. Protection of newborn Mx carriers against lethal infection with influenza virus.
Authors: O Haller, H Arnheiter, I Gresser, J Lindenmann
Journal: The Journal of Experimental Medicine (1981)

The efficacy of interferon in antiviral protection of newborn mice differing at the Mx locus was investigated. Adult mice bearing the allele Mx exhibit a high degree of specific resistance toward lethal challenge with influenza viruses. In contrast, newborn Mx carriers are virtually as susceptible to influenza viruses as newborn mice devoid of Mx. Resistance can be abrogated by treating adult animals with anti-interferon serum. Here, we provide direct evidence of a virus-specific effect of interferon in vivo: newborn mice carrying the resistance gene Mx could be protected against lethal influenza virus infection with doses of interferon that were not protective in the absence of Mx. The efficacy of interferon towards a picornavirus (encephalomyocarditis virus) and a rhabdovirus (vesicular stomatitis virus) was independent of Mx.