tbuckley/cabot-search huggingface dataset:
Effects of N‐acetyl‐aspartyl glutamic acid and sodium cromoglycate on leukotriene B<sub>4</sub> secretion by human leukocytes
Authors: P. L. Goldschmidt, B. Vulliez‐Le Normand, I. Briquet, F. Dray
Journal: Allergy (1990)

Peripheral leukocytes from allergic subjects were treated for 30 min with sodium cromoglycate (SCG) or with N‐acetyl‐aspartyl glutamic acid (NAAGA) and challenged for leukotriene B 4 (LTB 4 ) production with calcium ionophore A 23187. NAAGA significantly inhibits LTB, release at concentrations of 10 −2 M (−86%), 5.10 −3 M (−49%) and 10 −3 M (−34%), while SCG was not able to block LTB 4 production within the range of 10 −2 –10 −4 M. In spite of the fact that SCG and NAAGA are chemically unrelated and that both show antiallergic properties, only NAAGA is able in this model to block production of LTB 4 , a chemical mediator strongly involved in inflammatory and hypersensitivity reactions.
Contraceptive steroids and breast cancer.
Authors: J D Spencer, R R Millis, J L Hayward
Journal: BMJ (1978)

The prognosis and pathological findings in 44 patients with breast cancer who had taken contraceptive steroids during the year before diagnosis were compared with those in 44 controls matched for age and parity. No significant differences between the two groups were found in the histological features of the tumour or extent of axillary lymph-node disease. In patients with axillary node disease the recurrence rate in the controls was significantly higher than in the study group and more of the control patients had died. It is concluded that oral contraceptives have no untoward effect on the prognosis of breast cancer.
Agents to Control Bleeding Show Promise
Authors: Tracy Hampton
Journal: JAMA (2007)

Every year, thousands of patients develop deep vein thrombosis (DVT) and are at risk of pulmonary embolism after undergoing surgeries, particularly orthopedic procedures in the hips and legs. Although low-molecular-weight heparin is considered the standard therapy for DVT and other forms of venous thromboembolism, it is far from an ideal anticoagulant. Its drawbacks include the need for daily injections, adverse interactions with many types of drugs, and a wide variation in patient response. Researchers have therefore continued to search for alternative therapies. A phase 2 randomized, open-label trial funded by Sanofi-Aventis assessed the potential of idraparinux for preventing DVT and pulmonary embolism. This anticoagulant, which targets a molecule in the coagulation cascade, can be taken less often than low-molecular-weight heparin. In the study,2904patientswithaprevious DVT episode were randomized to receive idraparinuxbysubcutaneous injectiononceaweekorstandardtreatment, including daily injections of lowmolecular-weightheparin.After3months of therapy, idraparinux proved to be as effectiveas thestandardtreatment inpreventing venous clot recurrence (2.9% vs 3.0% recurrence respectively). Severe bleeding, apotential adverseeffectof anticoagulants,occurredin4.5%ofpatients taking idraparinux and in 7.0% of those receiving standard therapy.
Subclinical Coronary and Aortic Atherosclerosis Detected by Magnetic Resonance Imaging in Type 1 Diabetes With and Without Diabetic Nephropathy
Authors: Won Yong Kim, Anne Sofie Astrup, Matthias Stuber, Lise Tarnow, Erling Falk, René M. Botnar, Cheryl Simonsen, Lotte Pietraszek, Peter R. Hansen, Warren J. Manning, Niels T. Andersen, Hans-Henrik Parving
Journal: Circulation (2006)

Background— Patients with type 1 diabetes and nephropathy maintain an excess cardiovascular mortality compared with diabetic patients with normoalbuminuria. We sought to evaluate coronary and aortic atherosclerosis in a cohort of asymptomatic type 1 diabetic patients with and without diabetic nephropathy using cardiovascular magnetic resonance imaging. Methods and Results— In a cross-sectional study, 136 subjects with long-standing type 1 diabetes without symptoms or history of cardiovascular disease, including 63 patients (46%) with nephropathy and 73 patients with normoalbuminuria, underwent cardiovascular magnetic resonance imaging. All subjects underwent cardiac exercise testing and noninvasive tests for peripheral artery disease and autonomic neuropathy. Coronary artery stenoses were identified in 10% of subjects with nephropathy (versus 0% with normoalbuminuria; P =0.007). Coronary plaque burden, expressed as right coronary artery mean wall thickness (1.7±0.3 versus 1.3±0.2 mm; P &lt;0.001) and maximum right coronary artery wall thickness (2.2±0.5 versus 1.6±0.3 mm; P &lt;0.001), was greater in subjects with nephropathy. The prevalence of thoracic (3% versus 0%; P =0.28) and abdominal aortic plaque (22% versus 16%; P =0.7) was similar in both groups. Subjects with and without abdominal aortic plaques had similar coronary plaque burden. Conclusions— In asymptomatic type 1 diabetes, cardiovascular magnetic resonance imaging reveals greater coronary plaque burden in subjects with nephropathy compared with those with normoalbuminuria.
Abstract IA20: Deregulation of stem cell self-renewal pathways in cancer
Authors: Michael Clarke
Journal: Cancer Research (2013)

Abstract Most common cancers, such as cancers of the breast and colon, arise in organs such as the breast that contain a small population of stem cells that constantly replenish the mature cells of the tissue. Stem cells are defined by the ability to divide and give rise to a new stem cell (self-renewal), as well as the ability to give rise to the differentiated cells of an organ, and thus are the only long-lived cell population in many tissues. Extensive molecular and cellular analyses factors that play a role in the self-renewal of normal and malignant epithelial stem cells will be discussed. Citation Format: Michael Clarke. Deregulation of stem cell self-renewal pathways in cancer. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr IA20.
‐<sup>G</sup>γ<sup>A</sup>γ‐thalassemia and γ‐chain variants in chinese newborn babies
Authors: Yi‐Tao Zeng, Shu‐Zheng Huang, T. Nakatsuji, T. H. J. Huisman
Journal: American Journal of Hematology (1985)

Abstract The occurrence of γ‐chain abnormal hemoglobins and of γ‐thalassemia in Chinese newborns was evaluated through analyses of the Hb F of over 1,100 babies and of the DNA from one baby and his parents. Gene mapping data identified this baby as a homozygote for ‐ G γ A γ‐thalassemia, which is caused by a deletion of about 5 kb due to an unequal crossing‐over between the ‐ G γ‐ and ‐ A γ‐ genes. This condition is the same as that observed in Indian and Japanese babies [2,3]. Its gene frequency among babies from the Shanghai area was 0.012. A previously unrecognized G γ chain variant, Hb F‐Shanghai or α 2 G γ 2 66(E10)Lys→Arg, was observed in one newborn. This variant was not detected by conventional techniques but only by high performance liquid chromatography, as the G γ66 Lys and G γ66 Arg chains had slightly different chromatographic mobilities. Lys at position γ66 participates in contacts with the heme group, and its substitution by another amino acid residue might interfere with physiochemical and/or functional properties. No other γ‐chain variants have been detected except the well‐known A γ T or F‐Sardinia chain (f. A γ T = 0.076).
Skin Cells Reprogrammed to Be Stem Cells
Authors: Bridget M. Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gender-based differences in children with sepsis and ARDS: The ESPNIC ARDS Database Group
Authors: Lutz Bindl, Stephan Buderus, Peter Dahlem, Sueha Demirakca, Martin Goldner, Ralf Huth, Martina Kohl, Martin Krause, Peter K�hl, Peter Lasch, Klaus Lewandowski, Ulrich Merz, Jens Moeller, Yehya Mohamad, Mark Peters, Wolfgang Porz, Anne Vierzig, Jochen R�chard, Jochem Scharf, Verena Varnholt
Journal: Intensive Care Medicine (2003)
Structured telephone-based outreach using nonmedical personnel can improve adherence to comprehensive care in families of children with sickle cell disease
Authors: M. Patik, L. Phillips, B. Kladny, A. Captain, E. Gettig, L. Krishnamurti
Journal: American Journal of Hematology (2006)

Comprehensive medical care of patients with sickle cell disease decreases morbidity, mortality, and health care resource utilization. Nonadherence to comprehensive care is a barrier to further improvement in the outcomes of these patients. We investigated the feasibility and acceptability of telephone-delivered structured follow-up, support, and education provided by nonmedical personnel and its impact on adherence to comprehensive measures. A semistructured script was designed that included a series of questions relating to the patient's well-being and health-related behaviors and was administered by a graduate student researcher in genetics. Families of all 202 children followed at Children's Hospital of Pittsburgh were attempted to be contacted at 3 monthly intervals from their last contact. A total of 76% [147] of those called were available and willing to talk. Eighteen months after initiation of the study, the number of patients who had not attended comprehensive care clinic for 2 years or more decreased from 46 (19.7%) to 23 patients (9.9%) (P = 0.0019). Similarly, the proportion of eligible patients who had undergone transcranial Doppler screening within the past 12 months increased from 34 to 49% (P = 0.0501). Structured telephone-based follow-up is feasible and well accepted and can lead to improved adherence with comprehensive care measures.
Classifying Systolic and Diastolic Heart Failure—Reply
Authors: Véronique L. Roger, Francesca Bursi
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunogenicity and safety of an investigational multicomponent, recombinant, meningococcal serogroup B vaccine (4CMenB) administered concomitantly with routine infant and child vaccinations: results of two randomised trials
Authors: Timo Vesikari, Susanna Esposito, Roman Prymula, Ellen Ypma, Igor Kohl, Daniela Toneatto, Peter Dull, Alan Kimura
Journal: The Lancet (2013)
Endoscopic Sclerotherapy: The Value of Balloon Tamponade and the Importance of Disinfection
Authors: A. Elewaut, M. De Man, M. De Vos, F. Barbier
Journal: Endoscopy (1988)

Endoscopic sclerotherapy in active variceal bleeding stopped bleeding in 48 out of 67 patients (72%). Survival of the acute bleeding episode was related to liver function: 6% mortality in Child A patients vs. 48% mortality in Child C. Comparing two treatment modalities: 24 h Linton balloon tamponade followed by sclerotherapy vs. sclerotherapy alone, our results in comparable groups slightly, although not significantly, favor tamponade-sclerotherapy treatment: 75% survival vs. 71%. As this treatment modality is more convenient and helps to avoid dangerous aspiration pneumonia, we advocate balloon tamponade prior to sclerotherapy in acute variceal bleeding. In maintenance treatment 65 patients were treated until eradication of varices. The rebleeding risk was 0.034% per patient per month, with 64% of the rebleeding within the 2 first months before complete eradication of the varices. The long-term survival depends largely on liver function: one year survival of 88% in Child A vs. 30% in Child C. Using Aethoxysklerol 1% in intravariceal injection, no stricture occurred. Using a sterile injection needle and a glutaraldehyde-disinfected endoscope, no infectious complications directly related to the procedure occurred, and all hemocultures remained negative.
University of Craiova, Faculty of Physical education, Sports &amp; Kinesiology
Authors: Rusu Ligia
Journal: British Journal of Sports Medicine (2011)

Lecture 26 University of Craiova is one of the most important universities in Romania. It includes also Faculty of Physical Education, Sport and Kinesiology that prepare the future specialists in sport performance, trainers and sport rehabilitation. Most of the teachers of this faculty are sports medicine physicians and they have also medical activity in the Sport Medicine Department of Emergency Hospital Craiova. In our university we coordinate the programmes that included important aspects of sports medicine like: anatomy and biomechanic, physiology and sport physiology, rehabilitation and recovery in sport, sports medicine in chronic diseases. Practical activity included working with sports centres from south region of Romania, by specific assistance to athletes in Sports Medicine Department of our hospital. The sports medicine physicians in accordance with European Standards of Sports Medicine speciality give specific assistance by: clinical examination, cardiology exam, orthopaedic and rehabilitation exams, assessment of effort capacity and functional assessment, biometric assessment. The final diagnosis helps the athletes to have the best recommendations regards effort, nutrition, recovery and rehabilitation. In side of our university we have a research centre named ‘Research centre for study human body motricity’. This research centre has an activity in according with European ethics recommendations. It has departments for research in field of sports medicine and sport performance, sport rehabilitation using results of fundamental research regards how the sport activity induce functional and structural changes of human body. The centre has the following departments: motric anthropology, structural anthropology, kinesiology, physical therapy, sport medicine, statistic analyse of research. Focus group of our research are physicians from sports medicine, orthopaedics, rehabilitation and also athletes and trainers. Research activity in field of sports medicine is developed in relation with practical activity in field of sports by cooperation with sports centres like: athletic team, football teams, volleyball, handball and basket teams. In Romania sports medicine is a medical speciality and the future specialist have to prepare in this field for 4 years and they obtain the title of sports medicine physician specialist. During 4 years they obtain knowledge regards traumatology, physical therapy, cardiologic assessment of heart athletes, sport specific adaptations and specific rehabilitation and training.
Patenting Instruments and Apparatus
Authors: John D. Singley
Journal: JAMA (1910)

To the Editor:  A word by way of protest against the patenting of newly devised surgical instruments and apparatus by physicians. It has long been held that any improvement in the armamentarium of the physician should be given to the profession for the benefit of the sick and afflicted. For a physician to patent a method of laboratory technic or apparatus whose purpose is to aid in the diagnosis or prevention of disease is no worse from an ethical standpoint than the patenting of a surgical instrument.  The argument that the physician should profit in this way from his ingenuity and knowledge is fallacious. Otherwise the most laudable efforts of present-day medicine, the prevention of disease, should have no legitimate place in the physician's work.  A most glaring example of this evil has been the recent exploitation of a set of instruments for perforating the skull, which have been patented.
Nephritogenic Streptococcus Antigen
Authors: Samuel Vaisrub
Journal: JAMA (1977)

In a recent communication, Reeves<sup>1</sup>listed five areas of concern to clinical immunologists: immunodeficiency, lymphoproliferative disorders, autoimmune diseases, heteroimmune diseases, and therapeutic aspects of immunology. Surprisingly, he failed to mention infectious diseases, so closely linked historically and developmentally to immunology. For this omission, Reeves was taken to task by Bryceson,<sup>2</sup>who ascribed it to the gap that has developed in British medicine between immunology and the study of infectious disease—a gap for which preoccupation with chemotherapy may be partly responsible. It is possible that Reeves neglected to include infectious disease because the link between it and immunology is so selfevident as to be taken for granted. Whatever the reason, the increasingly strengthening bond between immunology and infectious disease is easily recognized even by the layman who follows the swine flu saga or reads about new vaccines for rabies and hepatitis B. The physician, of course, need not be
OC-021 Gastric Ulcer Follow-up: The Impact Of Nice Guidelines
Authors: R Cochrane, S Thanaraj, A Sainsbury, C Selinger
Journal: Gut (2014)

<h3>Introduction</h3> While the National Institute for Health and Care Excellence (NICE) recommends a follow-up gastrocopy (FU-OGD) within 8 weeks for all gastric ulcers to exclude malignancy, internationally this recommendation is controversial. This audit examined the impact of this NICE guideline. <h3>Methods</h3> All patients with a first endoscopic diagnosis of gastric ulcer between January 2012 and September 2013 at this large teaching hospital were included. Patients with known gastric ulcers prior to the study period or those referred for tertiary assessment were excluded. Patient demographics, data on endoscopic appearance and histological reports were recorded. We analysed endoscopic assessments, compliance with NICE guidance and the malignancy yield. <h3>Results</h3> 432 patients (53% male) with a mean age of 65 years presented with a gastrointestinal bleed (38%), anaemia (13%), dyspepsia (18%) or other symptoms (31%). 142 patients were not biopsied initially (73% GI bleed, 6% anticoagulation, 21% no reason). Of these 96 received FU-OGD for biopsies after a median of 7 days. 290 patients had an average of 4.8 biopsies taken on index endoscopy. Of these 194 underwent repeat OGD after a median of 70 days. Only 33% underwent FU-OGD within the recommended time frame. Reasons for not undergoing FU-OGD were failure to request (10%), deemed medically inappropriate (98%), death before FU-OGD due (12%), patient non-attendance (24%), malignancy on 1st biopsy (9%) and unknown (26%). Ulcer healing was found in 236 patients. Gastric neoplasia was found in 27 patients (19 adenocarcinomas, 2 cases of dysplasia, 5 lymphomas, 1 melanoma) leading to a diagnosis of malignancy in 6% of patients with gastric ulcers. Of these 25 (93%) were diagnosed on first biopsy. After excluding those patients without follow-up, the cancer yield of FU-OGD after initially benign biopsy was 2 of 225 patients (0.9%). <h3>Conclusion</h3> In this large cohort of patients with gastric ulcers 6% were found to have malignant disease. Of these over 90% were diagnosed with first biopsy, highlighting the need for all gastric ulcers to be biopsied. For many patients FU-OGD was deemed inappropriate. A high non-attendance rate was also noted, which may relate to the uncomfortable and invasive nature of endoscopy. While rapid FU-OGD for biopsies was achieved in those with no initial biopsies, many patients waited longer than the recommended 8 weeks after initial benign biopsies. However, the cancer yield of FU-OGD after benign biopsies remains low. Strategies to reduce the burden of FU-OGD for both patients and the health service would be highly desirable. <h3>Disclosure of Interest</h3> R. Cochrane: None Declared, S. Thanaraj: None Declared, A. Sainsbury: None Declared, C. Selinger Grant/research support from: Ferring, Nycomed, Shire, Warner Chilcott.
Nicardipine and cardiac hypertrophy: effects on left ventricular mass. Haemodynamics and mechanical performance in renovascular hypertensive rats
Authors: J Grellet, S Bonoron-Adele, B Stuyvers, L Tariosse, P Besse
Journal: Cardiovascular Research (1991)

Journal Article Nicardipine and cardiac hypertrophy: effects on left ventricular mass. Haemodynamics and mechanical performance in renovascular hypertensive rats Get access J Grellet, J Grellet J Grellet, S Bonoron-Adèle, B Stuyvers, L Tariosse, P Besse, Department of Physiology and Pharmacology, Unité de Recherches de Cardiologie, INSERM U8-Université de Bordeaux II, Bordeaux, France Search for other works by this author on: Oxford Academic PubMed Google Scholar S Bonoron-Adèle, S Bonoron-Adèle J Grellet, S Bonoron-Adèle, B Stuyvers, L Tariosse, P Besse, Department of Physiology and Pharmacology, Unité de Recherches de Cardiologie, INSERM U8-Université de Bordeaux II, Bordeaux, France Search for other works by this author on: Oxford Academic PubMed Google Scholar B Stuyvers, B Stuyvers J Grellet, S Bonoron-Adèle, B Stuyvers, L Tariosse, P Besse, Department of Physiology and Pharmacology, Unité de Recherches de Cardiologie, INSERM U8-Université de Bordeaux II, Bordeaux, France Search for other works by this author on: Oxford Academic PubMed Google Scholar L Tariosse, L Tariosse J Grellet, S Bonoron-Adèle, B Stuyvers, L Tariosse, P Besse, Department of Physiology and Pharmacology, Unité de Recherches de Cardiologie, INSERM U8-Université de Bordeaux II, Bordeaux, France Search for other works by this author on: Oxford Academic PubMed Google Scholar P Besse P Besse J Grellet, S Bonoron-Adèle, B Stuyvers, L Tariosse, P Besse, Department of Physiology and Pharmacology, Unité de Recherches de Cardiologie, INSERM U8-Université de Bordeaux II, Bordeaux, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 25, Issue 6, June 1991, Pages 484–490, https://doi.org/10.1093/cvr/25.6.484 Published: 01 June 1991 Article history Received: 01 May 1990 Accepted: 15 February 1991 Published: 01 June 1991