tbuckley/cabot-search huggingface dataset:
Engagement of I-Branching β-1, 6-<i>N</i>-Acetylglucosaminyltransferase 2 in Breast Cancer Metastasis and TGF-β Signaling
Authors: Haijun Zhang, Fanyan Meng, Sherwin Wu, Bas Kreike, Seema Sethi, Wei Chen, Fred R. Miller, Guojun Wu
Journal: Cancer Research (2011)

In this study, we have showed that GCNT2, a gene-encoding glucosaminyl (N-acetyl) transferase 2, I-branching enzyme, is overexpressed in highly metastatic breast cancer cell lines of human and mouse origin and basal-like breast tumor samples. GCNT2 expression is also significantly correlated to the metastatic phenotype in breast tumor samples. Functional studies showed that ectopic expression of GCNT2 enhances cell detachment, adhesion to endothelial cells, cell migration and invasion in vitro, and lung metastasis of breast cancer cells in vivo. Knockdown of GCNT2 expression decreases cell migration and invasion in vitro and lung metastasis in vivo. We have further shown the involvement of GCNT2 in the epithelial-to-mesenchymal transition (EMT). Specifically, the expression of E-cadherin is significantly changed upon GCNT2 expression at the protein level but not at the RNA level. Moreover, we have shown that GCNT2 is a direct target of the TGF-β-smad pathway and that change in GCNT2 expression modulates EMT induced by TGF-β1 treatment. Finally, we have shown that diminution of the glycosyltransferase activity of I-branching β-1, 6-N-acetylglucosaminyl transferase 2 (GCNT2) abrogates its cell migration and invasion-promoting function and synergistic effect with TGF-β to induce EMT. Our study for the first time showed that GCNT2 is a novel gene contributing to breast cancer metastasis with preferential expression in basal-like breast cancer. Moreover, we discovered that involvement of GCNT2 in EMT and TGF-β signaling, and further glycosylation modification of E-cadherin by GCNT2, are the underlying integrative mechanisms for breast cancer metastasis, implying that blocking TGF-β/GCNT2 signaling is a promising approach for targeting metastatic breast cancer.
In Vivo Comparison of Levothyroxine Preparations
Authors: Angelita Ramos-Gabatin
Journal: JAMA (1982)

Two brands of levothyroxine sodium (Levothroid and Synthroid) were found not to be bioequivalents. Until a more precise standardization for levothyroxine sodium preparation is available, patients should be consistently treated with one brand name preparation. Adjustment of the dosage may be necessary if the treatment is switched from one brand name preparation to another. (<i>JAMA</i>1982;247:203-205)
C14 studies of uric acid turnover.
Authors: J T Scott, R Arnot, H I Glass, V P Holloway
Journal: Annals of the Rheumatic Diseases (1968)

the right-hand side in a right-handed man, suggesting some correlation with use.In general, therefore, it may be that minor trauma, causing increase in vascular perme- ability, is a localizing factor, not only in relation to skin lesions, but possibly in relation to joint lesions also.DR. GOLDING: I do not think that the skin lesions were, in fact, more severe on the right than on the left side.Free Immunoglobulin Light Chains in Connective Tissue Diseases.
THREE CASES OF FAMILY DYSTROPHY OF THE HAIR AND NAILS
Authors: J. S. EISENSTAEDT
Journal: JAMA (1913)

Family dystrophy of the hair and nails is a hereditary condition previously noted, to the statistics of which I wish to add these cases. Two reports of the unusual condition have been published; one in France by Nicolle and Hallipré<sup>1</sup>the other in this country by Charles J. White.<sup>2</sup>Since that time the literature contains no further report. The three cases which I have observed are in many respects identical with the two previous eases cited, though occurring in patients enjoying somewhat better social and hygienic surroundings. My cases are in three brothers, the third, fifth and ninth children in a family of nine, eight of whom are living and in good health. One child, a girl, who was not affected, died in infancy. The following is a list of the living: Lee, aged 18; not affected. Sidney, aged
Pericarditis and Perimyocarditis Associated with Active Mycoplasma pneumoniae Infection
Authors: MILTON J. SANDS
Journal: Annals of Internal Medicine (1977)

In 13 patients an association existed from 1970-73 between Mycoplasma pneumoniae infection and acute pericarditis (in eight) or perimyocarditis (in five). In 12 patients the association was moderately probable, with a fourfold rise in complement-fixing antibody titers between acute and convalescent phase sera being noted. In the last patient, a lesser-order association was found using only convalsecent phase serum. The presence of influenza, herpes simplex, Coxsackie B, or adenovirus was excluded by serologic testing. Acute illness was variable, with four patients developing heart failure. Long-term evaluation (mean, 47 months) found eight patients asymptomatic and three symptomatic. Two patients died. Residual effects of the Mycoplasma infection seemed at least partially responsible in one compromised patient and in one who died. Mycoplasma infection should be considered in the presence of acute cardiovascular decompensation, especially when preceded by upper respiratory infection, and added to the possible causes of idiopathic cardiomyopathy.
Clinical and Molecular Characterization of Autosomal Recessive Hyper IgE Syndrome in Saudi Arabia
Authors: Z. Alsum, A. Hawwari, S. Al-Hifi, E. Borrero, H. Khalak, N. Ades, O. Alsmadi, R. Arnaout, A. Al-Ghonaium, S. Al-Muhsen, H. Al-Dhekri, B. Al-Saud, H. Al-Mousa
Journal: Journal of Allergy and Clinical Immunology (2012)
Efficacy of Topical Antifungals in the Treatment of Dermatophytosis
Authors: Inajara Rotta, Patricia K. Ziegelmann, Michel F. Otuki, Bruno S. Riveros, Noemia L. M. C. Bernardo, Cassyano J. Correr
Journal: JAMA Dermatology (2013)

<h3>Importance</h3>Considering that most randomized controlled trials compare antifungals with placebo instead of other antifungals, conventional meta-analysis is insufficient to define superiority between the evaluated strategies. To our knowledge, this is the first mixed-treatment comparison meta-analysis on antifungal treatments in the literature and shows all the evidence available at the time of the study.<h3>Objective</h3>To evaluate and compare the efficacy of topical antifungals used in dermatophytosis treatment, using mixed-treatment comparisons.<h3>Evidence Acquisition</h3>We performed a comprehensive search (up to July 31, 2012) for all entries in MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, Literatura Latino Americana e do Caribe em Ciências da Saúde, and International Pharmaceutical Abstracts. Randomized controlled trials that compared topical antifungals with one another or with placebo in dermatophytosis treatment were selected for analysis. Methodologic quality of the trials was assessed using the Jadad scale. We excluded studies that scored less than 3 points. The outcomes evaluated were mycologic cure at the end of treatment and sustained cure. A random-effects Bayesian mixed-treatment comparisons model was applied to combine placebo-controlled and direct topical antifungals comparison trials.<h3>Results</h3>Pooled data of the 65 trials identified did not show any statistically significant differences among the antifungals concerning the outcome of mycologic cure at the end of treatment. Regarding the sustained cure outcome, butenafine hydrochloride and terbinafine hydrochloride were significantly more efficacious than were clotrimazole, oxiconazole nitrate, and sertaconazole nitrate. Terbinafine also demonstrated statistical superiority when compared with ciclopirox (ciclopiroxolamine), and naftifine hydrochloride showed better response compared with oxiconazole. No inconsistency was detected in the network of evidence for both outcomes, sustaining the validity of the mixed-treatment comparisons results.<h3>Conclusions and Relevance</h3>With the outcome mycologic cure at the end of treatment, there was no significant difference among the antifungals. Butenafine, naftifine, and terbinafine might be the best strategies for maintaining cured status. Because of the different costs of the antifungals, pharmacoeconomic analysis is required to identify the most efficient strategy for dermatophytosis management.
Needle-Stick Exposure and Hepatitis
Authors: Max Bader
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In response to the question as to what action should be taken after accidental needle-stick exposure when the contact patient is not known to have hepatitis (240:2325, 1978), the Seattle-King County Health Department's viral hepatitis case survey results may be helpful. All patients whose cases were reported were contacted by a nurse and asked about possible exposure sources. These sources included work in the health professions and needle exposures. During a two-year period, only one patient recalled an accidental needle-stick exposure. It had occurred eight months before her illness, and she was given standard immune serum globulin at the time. Her hepatitis was not type B. Although only an estimated 40% to 50% of hepatitis cases were reported in the metropolitan Seattle area (1.2 million people) during that period, it seems safe to infer that while needle-stick exposures to serum from persons with unknown hepatitis antigen status
MULTICENTER EVALUATION OF THE PROGNOSTIC VALUE OF REAL TIME MYOCARDIAL PERFUSION IMAGING DURING DIPYRIDAMOLE VERSUS DOBUTAMINE STRESS ECHOCARDIOGRAPHY
Authors: Thomas Richard Porter, Juefei Wu, Feng Xie, Stacey Therrien, Valentina Lorenzoni, Sabrina Molinaro, Claudio Reverberi, Nicola Gaibazzi
Journal: Journal of the American College of Cardiology (2013)
Long-term ethanol consumption alters the hepatic response to the regenerative effects of tumor necrosis factor-α
Authors: Paul A. Akerman, Piera M. Cote, Shi Qi Yang, Craig McClain, Steve Nelson, Gregory Bagby, Anna Mae Diehl
Journal: Hepatology (1993)

The pathogenesis of chronic alcoholic liver disease is uncertain, but it may reflect an impaired wound healing response to ethanol-induced liver injury. Cell-to-cell communication such as that mediated by the cytokine tumor necrosis factor is necessary for successful liver regeneration and complete recovery from liver injury. Hence disruption of intercellular regenerative signaling may contribute to the pathogenesis of chronic alcoholic liver disease. To test this hypothesis, the cytokine and regenerative responses triggered by partial hepatectomy were compared in ethanol-fed rats and isocalorically maintained, pair-fed controls. To further clarify the effect of ethanol on tumor necrosis factor-modulated regenerative effects, we evaluated some of the rats in each feeding group after pretreatment with antibodies to tumor necrosis factor. As expected, ethanol inhibited DNA synthesis and liver cell proliferation after partial hepatectomy. Ethanol-associated inhibition of liver regeneration occurred despite apparently similar serum concentrations of the tumor necrosis factor-inducible cytokine interleukin-6. Treatment with antibodies to tumor necrosis factor 1 hr before partial hepatectomy inhibited post-partial hepatectomy induction of interleukin-6 and liver regeneration in ethanol-fed and pair-fed rats. However, serum interleukin-6 was reduced more in ethanol-fed rats than in control rats (93% vs. 66%; p < 0.05). Antibodies to tumor necrosis factor also inhibited hepatic DNA synthesis more in ethanol-fed rats than in controls (85% vs. 50%; p < 0.05). In ethanol-fed rats, the increased effect of tumor necrosis factor antibody on post-partial hepatectomy DNA synthesis suggests heightened sensitivity of hepatocytes to tumor necrosis factor.(ABSTRACT TRUNCATED AT 250 WORDS)
Atrial Electrocardiography for Diagnosis of Wide QRS Tachycardia
Authors: TED FELDMAN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 September 1986Atrial Electrocardiography for Diagnosis of Wide QRS TachycardiaTED FELDMAN, M.D.TED FELDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-462_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The caveats regarding initial therapy for wide QRS complex tachycardia presented by Stewart and coworkers (1) and the companion editorial (2) on diagnosis and therapy in the June issue are clear and pragmatic. Both articles emphasizethe importance of atrioventricular dissociation in the differential diagnosis of wide QRS tachycardia; atrioventricular dissociation is the hallmark of ventricular tachycardia. However, neither article mentions esophageal or atrial electrocardiography as a diagnostic aid for evaluation of the atrioventricular relation in patients with wide QRS tachycardia.In most patients, when the surface 12-lead electrocardiogram fails to show the presence or absence of atrioventricular...References1. STEWART R, BARDY G, and GREENE L. Wide complex tachycardia: misdiagnosis and outcome after emergent therapy. Ann Intern Med. 1986;104:766-71. LinkGoogle Scholar2. WELLENS H. The wide QRS tachycardia [Editorial]. Ann Intern Med. 1986;104:879. LinkGoogle Scholar3. HAMMILL S and PRITCHETT E. Simplified esophageal electrocardiography using bipolar recording leads. Ann Intern Med. 1981;95:14-8. LinkGoogle Scholar4. FELDMAN T and RESNEKOV L. Coexisting heart and lung disease: diagnosis and management. J Crit Illness. 1986;1:22-32. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: TED FELDMAN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Electrocardiographic Method for Positioning the Tip of Central Venous Catheters 1 September 1986Volume 105, Issue 3 Page: 462-462 Keywords Electrocardiography Tachycardia Ventricular tachycardia ePublished: 1 December 2008 Issue Published: 1 September 1986 PDF downloadLoading ...
Initial Experience With Remote Catheter Ablation Using a Novel Magnetic Navigation System
Authors: Sabine Ernst, Feifan Ouyang, Christian Linder, Klaus Hertting, Fabian Stahl, Julian Chun, Hitoshi Hachiya, Dietmar Bänsch, Matthias Antz, Karl-Heinz Kuck
Journal: Circulation (2004)

Catheters are typically stiff and incorporate a pull-wire mechanism to allow tip deflection. While standing at the patient's side, the operator manually navigates the catheter in the heart using fluoroscopic guidance.A total of 42 patients (32 female; mean age, 55+/-15 years) underwent ablation of common-type (slow/fast) or uncommon-type (slow/slow) atrioventricular nodal reentrant tachycardia (AVNRT) with the use of the magnetic navigation system Niobe (Stereotaxis, Inc). It consists of 2 computer-controlled permanent magnets located on opposite sides of the patient, which create a steerable external magnetic field (0.08 T). A small magnet embedded in the catheter tip causes the catheter to align and to be steered by the external magnetic field. A motor drive advances or retracts the catheter, enabling complete remote navigation. Radiofrequency current was applied with the use of a remote-controlled 4-mm, solid-tip, magnetic navigation-enabled catheter (55 degrees C, maximum 40 W, 60 seconds) in all patients. The investigators, who were situated in the control room, performed the ablation using a mean of 7.2+/-4.7 radiofrequency current applications (mean fluoroscopy time, 8.9+/-6.2 minutes; procedure duration, 145+/-43 minutes). Slow pathway ablation was achieved in 15 patients, whereas slow pathway modulation was the end point in the remaining patients. There were no complications.The Niobe magnetic navigation system is a new platform technology allowing remote-controlled navigation of an ablation catheter. In conjunction with a motor drive unit, this system was used successfully to perform completely remote-controlled mapping and ablation in patients with AVNRT.
Out of the mouths of babes . . . and beaks of birds? A broader interpretation of the frame/content theory for the evolution of speech production
Authors: Irene M. Pepperberg
Journal: Behavioral and Brain Sciences (1998)

Much of the material MacNeilage cites to support his frame/content theory for the evolution of speech production in humans is not unique to mammals. Parallels can be drawn for comparable evolution of vocal flexibility (specifically the reproduction of human speech) in birds. I describe several such parallels and conclude that MacNeilage's hypotheses may have broader application than he envisioned.
Apoptosis in normal and osteoarthritic human articular cartilage
Authors: F Héraud, A Héraud, M F Harmand
Journal: Annals of the Rheumatic Diseases (2000)

To investigate whether apoptosis occurs in osteoarthritis (OA), and if this phenomenon is modulated by human recombinant interleukin 1beta (hrIL1beta).Human articular cartilage samples were obtained at the time of hip arthroplasty because of femoral neck fracture (normal cartilage) (n=4) or advanced coxarthrosis (OA cartilage) (n=14). Apoptotic chondrocytes, isolated by collagenase digestion and cultivated for 24 hours, or present in situ in frozen cartilage sections, were quantified by fluorescent microscopy using two apoptosis markers: the TUNEL reaction, which detects nuclear DNA fragmentation, and Annexin-V-fluos, which labels at the membrane level the externalisation of phosphatidylserine.In OA cartilage 18-21% of chondrocytes showed apoptotic features, compared with 2-5% in normal cartilage. The results were similar for the two comparative studies (in situ and in vitro) and for both apoptosis markers. Moreover, hrIL1beta increased the apoptosis rate in vitro in a dose dependent manner in OA and normal chondrocytes.These results suggest that apoptosis may be an important factor in the evolution of OA and may be a new target for treatment of OA.
Mesenchymal Stem Cells and the Artery Wall
Authors: Moeen Abedin, Yin Tintut, Linda L. Demer
Journal: Circulation Research (2004)

The presence of ectopic tissue in the diseased artery wall is evidence for the presence of multipotential stem cells in the vasculature. Mesenchymal stem cells were first identified in the marrow stroma, and they differentiate along multiple lineages giving rise to cartilage, bone, fat, muscle, and vascular tissue in vitro and in vivo. Transplantation studies show that marrow-derived mesenchymal stem cells appear to enter the circulation and engraft other tissues, including the artery wall, at sites of injury. Recent evidence indicates that mesenchymal stem cells are also present in normal artery wall and microvessels and that they also may enter the circulation, contributing to the population of circulating progenitor cells and engrafting other tissues. Thus, the artery wall is not only a destination but also a source of progenitor cells that have regenerative potential. Although potential artifacts, such as fusion, need to be taken into consideration, these new developments in vascular biology open important therapeutic avenues. A greater understanding of how mesenchymal stem cells from the bone marrow or artery wall bring about vascular regeneration and repair may lead to novel cell-based treatments for cardiovascular disease.
997-84 Idiopathic Dilated Cardiomyopathy and the Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene
Authors: Hugh E. Montgomery, Phillip J. Keeling, Jonathen H. Goldman, Stephen E. Humphries, Phillipa J. Talmud, William J. McKenna
Journal: Journal of the American College of Cardiology (1995)
Diagnosis and Management of Obstetric Emergencies
Authors: Lionel J. Schewitz
Journal: JAMA (1983)

It is a pleasure to read a textbook that states its aims clearly and fulfills them with precision, completeness, and brevity. This multiauthored book is written primarily for family practitioners who include obstetric care in their services. I agree with the editor that the volume would be very useful also to nurse clinicians, midwives, and physician's assistants and offers an excellent review for obstetricians and obstetrical residents. The book provides an up-to-date account of the common and important emergencies of early and late pregnancy, the intrapartum and postpartum periods, and associated complications of pregnancy. Pertinent physiology and pathology are neatly summarized, and modern methods of preventive care are given due prominence. Controversy is usually avoided and, where differences of opinion might be expected, the safe and conservative course is appropriately recommended. Adequate references are given at the end of each chapter. Practical maneuvers are usually described in a lucid, simple
From the National Institutes of Health
Authors: W. R. Harlan
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maternal Blood Lead Levels and the Risk of Pregnancy-Induced Hypertension: The EDEN Cohort Study
Authors: Chadi Yazbeck, Olivier Thiebaugeorges, Thierry Moreau, Valérie Goua, Ginette Debotte, Josiane Sahuquillo, Anne Forhan, Bernard Foliguet, Guillaume Magnin, Rémy Slama, Marie-Aline Charles, Guy Huel
Journal: Environmental Health Perspectives (2009)

BackgroundPrior studies revealed associations of environmental lead exposure with risks of hypertension and elevated blood pressure.ObjectiveWe examined the effect of blood lead levels on blood pressure and the incidence of pregnancy-induced hypertension (PIH) in the second and third trimesters of pregnancy.MethodsOne thousand seventeen pregnant women were enrolled in two French municipalities between 2003 and 2005 for the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l′ Enfant) cohort study. Blood lead concentrations were measured by atomic absorption spectrometry in mothers between 24 and 28 weeks of gestation.ResultsPIH was diagnosed in 106 subjects (10.9%). Age, parity, weight gain, alcohol, smoking habits, and calcium supplementation were comparable between hypertensive and nonhypertensive women. Lead levels were significantly higher in PIH cases (mean ± SD, 2.2 ± 1.4 μg/dL) than in normotensive patients (1.9 ± 1.2 μg/dL; p = 0.02). Adjustment for potential confounder effects slightly attenuated but did not eliminate the significant association between blood lead levels and the risk of PIH (adjusted odds ratio of PIH = 3.3; 95% confidence interval, 1.1–9.7). We also observed geographic differences in lead exposure and in the incidence of PIH and found significant correlations between blood lead levels and unadjusted as well as adjusted systolic and diastolic blood pressures after 24 weeks of gestation.ConclusionsThese findings confirm the relationship between blood lead levels at mid-pregnancy and blood pressure and suggest that environmental lead exposure may play an etiologic role in PIH.