tbuckley/cabot-search huggingface dataset:
Coronary Stenting After Rotational Atherectomy in Calcified and Complex Lesions
Authors: Issam Moussa, Carlo Di Mario, Jeffrey Moses, Bernhard Reimers, Lucia Di Francesco, Giovanni Martini, Jonathan Tobis, Antonio Colombo
Journal: Circulation (1997)

Background Treatment of calcified (in contrast to simple) lesions with PTCA has been associated with a lower success rate and more procedural complications. Rotablation can improve acute results, but the high restenosis rate remains a problem. The purpose of this study was to evaluate the clinical and angiographic outcome of patients with complex and calcified lesions treated with a combination of rotablation and stenting. Methods and Results Seventy-five consecutive patients with 106 lesions had rotablation prior to coronary stenting. Intravascular ultrasound–guided stenting was used without subsequent anticoagulation in 93% of patients. Procedural success was achieved in 93.4% of lesions. Acute stent thrombosis occurred in two lesions (1.9%), and subacute stent thrombosis in one lesion (0.9%). Angiographic follow-up was performed in 82.5% of lesions at 4.6±1.9 months with an angiographic restenosis rate of 22.5%. Clinical follow-up was performed in all patients at 6.4±3 months; target lesion revascularization was needed in 18% of lesions, Q-wave myocardial infarction occurred in 1.3%, coronary bypass surgery in 4.0%, and death in 1.3%. Conclusions Optimal coronary stenting after rotablation in calcified and complex lesions can be performed with a high success rate, an acceptable rate of procedural complications, and a low rate of stent thrombosis. This approach was associated with a low incidence of angiographic restenosis compared with results usually obtained with other interventional strategies in calcified and complex lesion subsets.
French health costs rising rapidly
Authors: A. Dorozynski
Journal: BMJ (2000)

Health expenditure in France during the first half of this year has grown at a rate of 4.9 —almost twice the rate voted by parliament for the year 2000.

To control the rapidly increasing costs of health care parliament had voted an annual budget of Fr658.3bn (£61.2bn; $92bn) for the year 2000, which represented an increase of 2.5% over the previous year.

The highest increase …
CD5‐Negative, CD10‐Negative small B‐cell leukemia: Variant of chronic lymphocytic leukemia or a distinct entity?
Authors: Salwa S. Sheikh, Bhaskar V.S. Kallakury, Khawla A. Al‐Kuraya, Jeanne Meck, Dan P. Hartmann, Adam Bagg
Journal: American Journal of Hematology (2002)

CD5- and CD10-negative chronic lymphocytic leukemias are quite uncommon as compared to the CD5-positive CLL. We reviewed 250 sequential cases of peripheral blood lymphocytosis to characterize cases of small B-cell lymphoproliferative disorders, submitted with a clinical diagnosis of chronic lymphocytic leukemia exhibiting a non-classic immunophenotypic profile. Six cases of CD5-, CD10-negative chronic lymphocytic leukemias and no tissue involvement were identified that revealed high-density surface-membrane immunoglobulin and CD20 expression, with variable expression of CD11c, CD23, and CD25. Most had a profound leukocytosis (mean WBC 180 x 10(9)/L) with proliferation of mature-appearing lymphocytes. Subsequent bone marrow biopsies showed diffuse infiltration by neoplastic cells in all evaluated patients. The clinical course appeared indolent, with follow-up revealing three patients alive (survival time 38-68 months), while two died of unrelated causes and one was lost to follow-up soon after diagnosis. These cases may represent somewhat unusual chronic lymphoproliferative disorders, with morphologic features and immunophenotypic profile not readily classifiable, but which are certainly atypical for classic chronic lymphocytic leukemia. Some of these features are reminiscent of those seen in marginal-zone lymphoma. However, it is most unusual for this known to be tissue-based disease to present primarily as leukemia rather than lymphoma.
Review calls for improved patient identification systems for blood
Authors: S. Mayor
Journal: BMJ (1999)

Unique patient identification systems are being recommended in a report from a steering group of all professions involved in blood transfusion in the British Isles, in response to a review showing increased reports of incidents involving incorrect components being transfused.

The Serious Hazards of Transfusion group–which includes representatives from eight Royal Colleges plus other professional bodies–has suggested that funding should be provided to evaluate and develop computerised …
B. I. Chi-Lum, MD, Is 14th JAMA Fishbein Fellow
Authors: Phil Gunby
Journal: JAMA (1994)

BONNIE I. CHI-LUM, MD, becomes<i>JAMA</i>'s 14th Morris Fishbein Fellow in Medical Journalism on July 1. She is about to receive a master of public health degree (health administration) from Loma Linda (Calif) University, from which she also received her undergraduate and MD degrees and where—in addition to Kaiser Permanente Hospital, Fontana—she received postgraduate training. She is scheduled to hold the Fishbein Fellowship in<i>JAMA</i>'s Chicago, Ill, offices through June 30, 1995. <h3>History of the Fellowship</h3> The fellowship itself honors Morris Fishbein, MD, who served longer (1924 to 1949) than any other physician as editor of<i>JAMA</i>. He died nearly 18 years ago (<i>JAMA</i>. 1976;236:1820-1822) at the age of 87. Within months of his death came the announcement of "The 1977-1978 American Medical Association Dr Morris Fishbein Fellowship in Medical Journalism." Jeffrey R. M. Kunz, MD, became the first recipient (<i>JAMA</i>. 1977; 238:464). Since then, holders of the
Trastuzumab Treatment in T1ab, Node-Negative, Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Carcinomas
Authors: Manuel Jorge Rodrigues, Johanna Wassermann, Laurence Albiges, Etienne Brain, Suzette Delaloge, Denise Stevens, Jean-Marc Guinebretière, Marie-Christine Mathieu, Youlia Kirova, Eugénie Guillot, Anne Vincent-Salomon, Paul H. Cottu
Journal: Journal of Clinical Oncology (2010)
Effects and Correlates of Blood Glucose Awareness Training Among Patients With IDDM
Authors: Daniel J Cox, Linda A Gonder-Frederick, Jana H Lee, Diana M Julian, William R Carter, William L Clarke
Journal: Diabetes Care (1989)

Whereas self-monitoring of blood glucose (SMBG) is the recommended source of information on which to make self-care decisions, patients frequently use estimates of their own blood glucose (BG). This study evaluated whether patients with insulin-dependent diabetes mellitus (IDDM) could learn to improve accuracy of BG estimations and whether this would lead to improved metabolic control. Subjects in BG awareness training improved both their BG-estimation accuracy and glycosylated hemoglobin (HbA1) compared with the control group. Initial BG-estimation accuracy was marginally associated with pretreatment HbA1 and months of previous SMBG experience. Posttreatment improvement was associated with pretreatment BGestimation accuracy and the ability to counterregulate to insulin-induced hypoglycemia.
Treatment of Pulmonary Mycotic Infections with Amphotericin B
Authors: Daniel E. Smith, James H. Matthews
Journal: New England Journal of Medicine (1960)

EFFECTIVE therapy for most of the deep mycoses has not been available until recently. With the exceptions of iodides for sporotrichosis, penicillin for actinomycosis, sulfadiazine for nocardiosis and the stilbamidines for blastomycosis, drug therapy of mycotic infections was generally disappointing before the use of the antifungal antibiotic, amphotericin B.Early reports1 , 2 on amphotericin B treatment of patients with histoplasmosis and cryptococcosis were favorable. Subsequently, it was demonstrated that amphotericin B is also effective in the treatment of coccidioidomycosis,3 , 4 North American blastomycosis5 and other systemic fungous infections.6 Since the total reported experience with this drug is still small, a report of . . .
Sudden infant death syndrome and advice for safe sleeping
Authors: R. S. C. Horne, F. R. Hauck, R. Y. Moon
Journal: BMJ (2015)

#### The bottom line

Sudden infant death syndrome (SIDS) is currently defined as “the sudden and unexpected death of an infant under 1 year of age, with the onset of the lethal episode apparently occurring during sleep, that remains unexplained after a thorough investigation including performance of a complete autopsy and review of the circumstances of death.”1 Before this 2004 definition a diagnosis of SIDS did not require a death scene investigation or to have occurred during sleep, and therefore the definition for SIDS varies in the studies cited in this review.

#### Sources and selection criteria

We searched PubMed for articles in English published between 1980 and January 2015 using the search terms “sudden infant death syndrome”, “SIDS”, and “cot death”. To date most studies have used a case-control design and there are no randomised controlled trials. The information in this review results primarily from the literature arising from these case-control studies and from the policy statements and …
A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential
Authors: Ares Rocanin-Arjo, William Cohen, Laure Carcaillon, Corinne Frère, Noémie Saut, Luc Letenneur, Martine Alhenc-Gelas, Anne-Marie Dupuy, Marion Bertrand, Marie-Christine Alessi, Marine Germain, Philipp S. Wild, Tanja Zeller, Francois Cambien, Alison H. Goodall, Philippe Amouyel, Pierre-Yves Scarabin, David-Alexandre Trégouët, Pierre-Emmanuel Morange
Journal: Blood (2013)
Parental History and Myopia: Taking the Long View
Authors: Josh Wallman
Journal: JAMA (1994)

<h3>To the Editor.</h3> —I wish to take issue with the conclusions of Dr Zadnick and colleagues<sup>1</sup>that the slightly greater incidence of myopia and long eyes among the school-age children of myopes is evidence for a strong genetic determination of myopia. I would like to suggest how environmental influences might produce such results, to correct a technical error, and to point out a misleading interpretation. Consider that there are two mechanisms for clearing blurred images: accommodation, which rapidly adjusts the optical power of the lens, and emmetropization, which slowly adjusts the length of the eye during growth (shown clearly by animals compensating for myopia or hyperopia imposed by spectacle lenses<sup>2</sup>). Because the two mechanisms act in parallel, the better accommodation is, the more in focus images would be, and the less the eye would need to elongate and become myopic to clear the images. Conversely, poor accommodation might
Abstract 1392: HEDS selectively radiosensitizes human cancer cells in glucose-deprived environments via inhibition of Ku protein function
Authors: Kathleen M. Ward, Jie Li, Donglan Zhang, Eswarkumar Dayanandam, Albert S. DeNittis, George C. Prendergast, Iramoudi S. Ayene
Journal: Cancer Research (2010)

Abstract There remains great interest in strategies to increase the efficacy of radiation therapy in cancer patients. Glucose depletion occurs commonly in certain regions of bulky solid tumors, owing to high glucose metabolism combined with poor perfusion caused by a disorganized blood vasculature. Evidence suggests that cancer cells located in glucose-deprived regions are resistant to therapeutic killing. Agents that sensitize glucose-deprived cancer cells might offer useful adjuvants for tumor radiotherapy. In an earlier study, we demonstrated that rodent cells which are genetically deficient in the oxidative pentose phosphate cycle (OPPC) display a heightened response to hydroxyethyldisulfide (HEDS), a thiol-specific oxidant that can radiosensitize cells by blocking the redox-dependent function of DNA repair protein Ku. Since glucose is the chief substrate of the OPPC, and the OPPC is responsible for detoxifying HEDS, we reasoned that glucose deprivation should phenocopy the effects of OPPC deficiency in enhancing radiosensitization by HEDS. To test this prediction, we compared the effects of HEDS treatment in human colon cancer cell lines HCT116 or HT29, which are radiation sensitive or resistant, respectively. In both cell lines, HEDS was detoxified by OPPC-mediated conversion to mercaptoethanol (ME) in high-glucose media but not in low-glucose media. Consistent with the decrease in cellular bioreductant activity by glucose depletion, HEDS greatly decreased free glutathione levels under low-glucose conditions. Similarly, HEDS greatly decreased the free thiol content of total proteins and impaired the Ku DNA binding activity in low-glucose conditions. Most significantly, in clonogenic cell growth assay, the cytotoxic effects of HEDS were greatly increased under low glucose conditions, when added by itself to HCT116 cells but particularly when added in combination with irradiation to HCT116 or HT29 cells. Together, our findings indicate that glucose depletion enhances the ability of HEDS to radiosensitize cancer cells. More broadly, our findings suggest the potential to use HEDS in a novel strategy to enhance killing of radioresistant regions of tumors that are characterized by a glucose-depleted state. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1392.
Effects of increased pericardial pressure on the coupling between the ventricles
Authors: W. P Santamore, K. S Li, T. Nakamoto, W. E Johnston
Journal: Cardiovascular Research (1990)

Journal Article Effects of increased pericardial pressure on the coupling between the ventricles Get access William P Santamore, William P Santamore Correspondence to: Dr Santamore Search for other works by this author on: Oxford Academic PubMed Google Scholar Kun S Li, Kun S Li Search for other works by this author on: Oxford Academic PubMed Google Scholar Takaaki Nakamoto, Takaaki Nakamoto Search for other works by this author on: Oxford Academic PubMed Google Scholar William E Johnston William E Johnston Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 9, September 1990, Pages 768–776, https://doi.org/10.1093/cvr/24.9.768 Published: 01 September 1990 Article history Received: 11 December 1989 Accepted: 18 April 1990 Published: 01 September 1990
Ammonia in the upper gastrointestinal tract of man: quantitations and relationships.
Authors: W H Summerskill, T Aoyagi, W B Evans
Journal: Gut (1966)

EDITORIAL SYNOPSIS This paper concerns the concentration and output of ammonia in the stomach, duodenum, and jejunal juices in health and in various diseases.The effects of gastric, pancreatic, and biliary secretions are measured and it is suggested that ammonia undergoes non-ionic diffusion across the gut membrane relevant to the different pH levels.The place of upper gastrointestinal dialysis with acid is considered for the management of hyperammonaemia.
High Prevalence of Recent Cocaine Use and the Unreliability of Patient Self-report in an Inner-city Walk-in Clinic
Authors: Sally E. McNagny
Journal: JAMA (1992)

To determine the prevalence of recent cocaine use and the reliability of patient self-reported cocaine use.A survey with blinded comparison to a criterion standard.Walk-in clinic of a large public hospital in metropolitan Atlanta, Ga.Male patients, aged 18 to 39 years, presenting to the triage desk for immediate care during weekdays. Of the 415 eligible men who agreed to participate (acceptance rate, 82%), the average age was 29.5 years, 91.6% were black, and 89% were uninsured.None.Comparison of self-reported illicit drug use with results from urinary immunoassays for benzoylecgonine, a major cocaine metabolite. Determination of which drug history questions produce the most accurate responses using anonymous urine testing as the criterion standard.Thirty-nine percent of patients tested positive for the presence of benzoylecgonine and were statistically more likely to be older, black, and have a prior history of sexually transmitted disease (P less than .01). Seventy-two percent of men with positive urinary assays denied illicit drug use in the 3 days prior to sampling. When queried with several formats, subjects with positive urine assays were more likely to admit to "any illegal drug" use (87.5%) than to the more specific "any form of cocaine" use (60.6%) within the prior year (P less than .0001).These results underscore the magnitude of cocaine abuse among black, inner-city men. Patient self-report of illicit drug use is highly inaccurate. Accuracy of self-report may be increased by asking less specific questions.
Tumor Radiosensitization by Monomethyl Auristatin E: Mechanism of Action and Targeted Delivery
Authors: Lisa Buckel, Elamprakash N. Savariar, Jessica L. Crisp, Karra A. Jones, Angel M. Hicks, Daniel J. Scanderbeg, Quyen T. Nguyen, Jason K. Sicklick, Andrew M. Lowy, Roger Y. Tsien, Sunil J. Advani
Journal: Cancer Research (2015)

Abstract Intrinsic tumor resistance to radiotherapy limits the efficacy of ionizing radiation (IR). Sensitizing cancer cells specifically to IR would improve tumor control and decrease normal tissue toxicity. The development of tumor-targeting technologies allows for developing potent radiosensitizing drugs. We hypothesized that the anti-tubulin agent monomethyl auristatin E (MMAE), a component of a clinically approved antibody-directed conjugate, could function as a potent radiosensitizer and be selectively delivered to tumors using an activatable cell-penetrating peptide targeting matrix metalloproteinases and RGD-binding integrins (ACPP–cRGD–MMAE). We evaluated the ability of MMAE to radiosensitize both established cancer cells and a low-passage cultured human pancreatic tumor cell line using clonogenic and DNA damage assays. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule- and dose-dependent manner, correlating with mitotic arrest. Radiosensitization was evidenced by decreased clonogenic survival and increased DNA double-strand breaks in irradiated cells treated with MMAE. MMAE in combination with IR resulted in increased DNA damage signaling and activation of CHK1. To test a therapeutic strategy of MMAE and IR, PANC-1 or HCT-116 murine tumor xenografts were treated with nontargeted free MMAE or tumor-targeted MMAE (ACPP–cRGD–MMAE). While free MMAE in combination with IR resulted in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produced a more robust and significantly prolonged tumor regression in xenograft models. Our studies identify MMAE as a potent radiosensitizer. Importantly, MMAE radiosensitization can be localized to tumors by targeted activatable cell-penetrating peptides. Cancer Res; 75(7); 1376–87. ©2015 AACR.
Another Side of the Life Insurance Question.
Authors: W. W. Vinnedge
Journal: JAMA (1895)

La Fayette, Ind., Oct. 2, 1895. <h3>To the Editor:</h3> —Allow me to call attention to the communication of Dr. John L. Davis, Medical Director of the Union Central Life Insurance Company, Cincinnati, which appears in theJournalof September 23, page 524, in order to speak briefly in behalf of the members of the common herd in the profession who are interested directly and indirectly in the subject of professional work for life insurance companies. I am glad that the Doctor has discussed, in a public way, the practical side of the life insurance question in its relation to the medical profession; for I do not know of any one professional topic that needs it more. The perusal of the Doctor's article gives me the impression that its author is only practically familiar with the whole question theoretically, and that his opinions and estimates of the local examiner have been
Demand v Need v Physician Prerogatives in the Use of the WBC Differential
Authors: William A. Rock
Journal: JAMA (1983)

The clinical use of the WBC differential was investigated before and after it was made available on demand. The results indicate that no consistent policy existed in our hospital for the ordering of a differential. When differentials were made available on demand, the number of differentials did not increase compared with earlier periods. The demand for differentials may have been caused more by the denial of a physician's prerogative to order a differential rather than by its requirement for patient care. (<i>JAMA</i>1983;249:613-616)
EARLY STENTING VERSUS CONSERVATIVE TREATMENT AFTER SUCCESSFUL FIBRINOLYSIS FOR STEMI: RESULTS OF THE RANDOMIZED ANGIOGRAPHIC APRICOT-3 TRIAL
Authors: Hendrik-Jan Dieker, Wim R. Aengevaeren, John French, Kurt Huber, Marc Brouwer, Freek Verheugt
Journal: Journal of the American College of Cardiology (2012)
Identification and care pathways for common mental health disorders: summary of NICE guidance
Authors: S. Pilling, C. Whittington, C. Taylor, T. Kendrick
Journal: BMJ (2011)

At any one time, as many as 15% of people in the United Kingdom1 experience common mental health problems such as depression and anxiety disorders, including generalised anxiety disorder, panic disorder, post-traumatic stress disorder, and obsessive-compulsive disorder. These may cause considerable impairment and disability, with high costs for both the person and society. Most people who are diagnosed with a common mental health disorder (about 80%) are treated in primary care2; however, there is widespread under-recognition of depression and anxiety disorders.3 4

This article summarises the most recent recommendations from the National Institute for Health and Clinical Excellence (NICE) to improve identification of common mental health disorders, access to services, and pathways to care.5 The guideline also adopted or adapted treatment recommendations from existing NICE guidance on depression,6 7 generalised anxiety disorder and panic disorder,8 post-traumatic stress disorder,9 obsessive-compulsive disorder,10 and antenatal and postnatal mental health11 and organised them into a common stepped care framework.

NICE recommendations are based on systematic reviews of best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the Guideline Development Group’s experience and opinion of what constitutes good practice. Evidence levels for the recommendations are in the full version of this article on bmj.com.

### Identification of common mental health disorders

If a person answers “yes” to either of the above questions consider depression and follow …