tbuckley/cabot-search huggingface dataset:
When my fiercely independent friend died
Authors: M. Barnard
Journal: BMJ (2012)

<h3>Background and Objectives</h3> Ultrasound-guided needle placement is a widely used technical skill that can be challenging to learn. The SonixGPS is a novel ultrasound needle-tracking system that has the potential to improve performance over traditional ultrasound systems. The objective of our study was to determine if the use of the SonixGPS ultrasound system improves performance of novice practitioners in ultrasound-guided needle placement compared with conventional ultrasound in the out-of-plane approach on a simulation model. <h3>Methods</h3> Twenty-six medical students without previous ultrasound experience were randomized into 2 groups. Each group performed 30 simulated ultrasound nerve blocks on a porcine meat tissue simulation (phantom) model. Both groups used the SonixGPS ultrasound; however, the study group had the needle-tracking system activated, whereas the control group did not. The participants were assessed for success rate, technical aspects of block performance, and certain behaviors that could compromise the quality of the block. Learning curves were developed to assess competence. <h3>Results</h3> The needle guidance group reached competence more often. This group had fewer attempts and quality-compromising behaviors than did those using conventional ultrasound. <h3>Conclusions</h3> Use of the SonixGPS ultrasound needle guidance system improves the performance of technical needling skills of novice trainees in an ex vivo model. The place of this technology in the wider education of ultrasound-guided regional anesthesia remains to be established.
Longterm effects of endoscopic sphincterotomy on gall bladder motility.
Authors: M Sugiyama, Y Atomi
Journal: Gut (1996)

BACKGROUND: Some of patients with an intact gall bladder develop acute cholecystitis or have gall bladder stone formation after endoscopic sphincterotomy. Endoscopic sphincterotomy may affect gall bladder motility. AIMS: To prospectively evaluate longterm effect of endoscopic sphincterotomy on gall bladder motility. PATIENTS: Thirty two patients with an intact gall bladder (15 with and 17 without gall bladder stones) who underwent endoscopic sphincterotomy for choledocholithiasis. METHODS: Gall bladder function was examined before and at from seven days to five years after sphincterotomy. Gall bladder volume, at fasting and after caerulein administration, was determined by ultrasonography. RESULTS: After endoscopic sphincterotomy, the enlarged orifice remained patent during a five year follow up period. One patient with gall bladder stones subsequently developed acute cholecystitis, the remaining being asymptomatic. In the patients before sphincterotomy, particularly in those with gall bladder stones, the gall bladder showed larger fasting volume and lower caerulein stimulated maximum contraction than normal controls. Throughout five years after sphincterotomy, fasting volume of the gall bladder decreased and its maximum contraction increased, regardless of gall bladder stones; significantly different from the values before sphincterotomy (p &lt; 0.05). CONCLUSIONS: Endoscopic sphincterotomy decreases fasting volume of the gall bladder and increases its contraction ability for a long period. These changes may rather decrease the risk of future acute cholecystitis or gall stone formation.
H REFLEX FROM SOLEUS MUSCLE AFTER ANKLE SPRAIN OF A COLLEGE BASKETBALL PLAYER
Authors: S Daikuya, A Ono, K Yabe
Journal: British Journal of Sports Medicine (2014)

Background In our previous study, we reported the neuro-muscular function after the reconstruction of anterior cruciate ligament was changed compared with healthy subjects by electrophysiological study. In this study, the electrophysiological findings were reported in the patient with ankle sprain. Objective To clarify that the fluctuation of the excitability of spinal neural function after ankle sprain, we studied the alteration of H-reflex from the soleus muscle in a patient with ankle sprain. Design and setting This study was the single case research, which belonged to the basketball team in university first division. Patient Subject was 21-year-old male college basketball player, left ankle inversed sprain (grade II). There were swelling, pain and instability. As for the activity of daily life, walking in pain was appeared, and going up and down stairs was needed too much time. Main outcome measurements H-reflex from soleus muscle was recorded at before injury (medical check), three days after injury and one month after injury. H-reflex and maximal M wave from the bilateral soleus muscle were evoked at rest and amplitude ratio of H/Mmax (H/Mmax) was calculated and H/Mmax was compared between after and before injury. Results H/Mmax was increased at three days after ankle sprain on both injured side and non-injured side compared with both before and one month after injury, and long-latency-reflex was appeared on the only injured side after three days. After one month, electrophysiological findings became the same as before injury. Conclusions It was cleared that the excitability of spinal and supra-spinal neural function related to soleus muscle at three days after was increased due to pain, joint effusion and/or instability. Even if a slight injury like ankle sprain, the neural function has to be paid attention at least one month after injury in the field of physiotherapy.
The Hospitalized Child — His Emotional Needs
Authors: Edward A. Mason
Journal: New England Journal of Medicine (1965)

HOSPITALIZATION as a significant psychologic event in childhood has been a focus of concern, investigation and action for two decades. The postwar interest in psychiatry, combined with the therapeutic controls made possible by antibiotics, encouraged a surge in the trend toward humanizing the care of children. During the decade 1944–53 several basic studies were undertaken that gave rise to dramatic and frequently controversial revisions; in the following decade the changes seem to have been less publicized but more widespread. Because these changes have often been on the basis of personal conviction more than on empirical evidence, objections have risen among . . .
P59 YES-ASSOCIATED PROTEIN (YAP) IS REQUIRED FOR THE CLONAL EXPANSION OF PRENEOPLASTIC HEPATOCYTES AND OVAL CELL PROLIFERATION
Authors: M.A. Kowalik, A. Perra, E. Ghiso, G.M. Ledda-Columbano, S. Giordano, A. Columbano
Journal: Journal of Hepatology (2014)
Phagocytosis of Staphylococci Seen in Peripheral Blood Smear
Authors: LeRoy W. Falkinburg, Edward J. West, Fouad E. Yazbak, Albert V. Troppoli
Journal: JAMA (1962)

A FEW ORGANISMS capable of causing septicemia invade the host in such massive and overwhelming numbers that they are visible intracellularly and extracellularly in the ordinary peripheral blood smear. Five organisms have been known to produce such fulminating infection, i.e.,<i>Pasteurella pestis, Neisseria meningitidis, Bacillus anthracis,</i>Staphylococcus, and Streptococcus. We have recently encountered a case of overwhelming staphylococcal septicemia in which this phenomenon was noted and we believe that the circumstances are unusual enough to report. Report of a Case <i>History</i>.—A 19-year-old woman bank teller was admitted to the Charles V. Chapin Hospital on Oct. 24, 1961, stuporous, febrile, and complaining of severe headache. Three weeks before admission she suffered from coryza accompanied by severe headaches and chills. She received an antihistaminic drug, improved, and was able to return to work. Ten days prior to admission she again suffered from severe headache, malaise, anorexia, and fever. She received parenteral penicillin
Central Nervous System Toxicity Induced by Lidocaine
Authors: Richard Selden
Journal: JAMA (1967)

Lidocaine-hydrochloride-induced central nervous system (CNS) toxic effects in a patient with liver disease occurred after an intravenous infusion of the drug in a dose much smaller than is tolerated by patients with normal hepatic function. To the best of our knowledge, this is the first clinical description of the CNS manifestations of lidocaine in a patient with hepatic insufficiency.
Treatment-Refractory Depression
Authors: Richard A. Rovin
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epithelial barrier function and atopic diathesis in rosacea and perioral dermatitis
Authors: T. Dirschka, H. Tronnier, R. Folster-Holst
Journal: British Journal of Dermatology (2004)

Rosacea and perioral dermatitis (PD) are common dermatoses, the aetiology and pathogenesis of which remain speculative. Objectives To investigate skin barrier function and features of atopy in both diseases.We studied 75 patients with rosacea and 75 with PD. Transepidermal water loss (TEWL) was measured in three regions of the face (lateral chin, perinasal cheek, side of the nose) and the patients were assessed for atopy by clinical criteria, prick tests and specific IgE against a mixture of aeroallergens (CAP SX1). The control group consisted of 125 individuals with no history of rosacea, PD or active atopic disease.In patients with PD, TEWL was significantly increased (P < 0.001) at all measurement points in comparison with the rosacea and control groups. Significantly (P < 0.001) higher values were also found regarding history and clinical signs of an atopic diathesis, prick test reactivity and specific IgE against aeroallergens.PD is characterized by a skin barrier disorder of facial skin. It differs from rosacea in that it involves a significantly increased TEWL and features of an atopic diathesis. However, it remains disputed as to whether PD is an individual skin disease or a subtype of rosacea in atopic patients.
Diagnostic sensitivity of puncture skin testing (PST) with isolated native and recombinant proteins from Hevea brasiliensis (Hev b) for the diagnosis of latex hypersensitivity in healthcare workers (HCWs)
Authors: Raymond Biagini, David I Bernstein, Ravi Karnani, Karen Murphy, Cheryl Bernstein, Brian Berendts, Jonathan A Bernstein, I Leonard Bernstein, Carol Abbott, Hoong-Yeet Yeang
Journal: Journal of Allergy and Clinical Immunology (2002)
CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness
Authors: Patrick Michl, Antoine R. Ramjaun, Olivier E. Pardo, Patricia H. Warne, Martin Wagner, Richard Poulsom, Corrado D’Arrigo, Kenneth Ryder, Andre Menke, Thomas Gress, Julian Downward
Journal: Cancer Cell (2005)
Improvement of estradiol 17β-D-glucuronide cholestasis by intravenous administration of dimethylethanolamine in the rat
Authors: Domenico Alvaro, Mario Angelico, Alfredo Cantafora, Eugenio Gaudio, Claudia Gandin, Maria Teresa Santini, Roberta Masella, Livo Capocaccia
Journal: Hepatology (1991)

The intravenous administration of dimethylethanolamine in the rat promotes a selective enrichment of liver membranes with polyunsaturated phosphatidylcholines. The effect of dimethylethanolamine pretreatment on cholestasis induced by estradiol 17 beta-D-glucuronide, a potent cholestatic agent, was assessed in this study. Dimethylethanolamine, dissolved in sodium-taurocholate was infused intravenously (0.3 mg/kg/min) for 15 hr. One group of control rats (estradiol 17 beta-D-glucuronide controls) received the bile salt only. An estradiol 17 beta-D-glucuronide bolus was then injected intravenously (10.4 mg/kg) into dimethylethanolamine-pretreated and estradiol 17 beta-D-control rats, and its effect on bile flow and biliary lipid secretion was compared for 3 hr. The estradiol 17 beta-D-glucuronide inhibitory effect on bile flow and biliary lipid secretion was significantly antagonized by dimethylethanolamine pretreatment. The maximum inhibition of bile flow was found 30 min after estradiol 17 beta-D-glucuronide administration, when it decreased from 3.5 +/- 0.4 microliters/min/100 gm (basal) to 0.9 +/- 0.3 microliters/min/100 gm in estradiol 17 beta-D-glucuronide controls, whereas in dimethylethanolamine-pretreated rats this decreased only from 3.2 +/- 0.4 (basal) to 2.3 +/- 0.4 microliters/min/100 gm. Bile flow and the biliary secretion of cholesterol, phosphatidylcholine and bile salts were significantly higher in the dimethylethanolamine-pretreated rats than in estradiol 17 beta-D-glucuronide controls (p less than 0.02) during the cholestatic phase. The inhibitory effect of estradiol 17 beta-D-glucuronide on bile flow was associated with a marked decrease of membrane fluidity (p less than 0.001) assessed by 1,6-diphenyl-1,3,5-hexatriene fluorescence anisotropy and with a cholesterol enrichment of microsomes, sinusoidal and canalicular liver plasma membranes and inhibition of sinusoidal Na+,K(+)-ATPase activity (p less than 0.05). These membrane alterations persisted 180 min after estradiol 17 beta-D-glucuronide administration despite complete normalization of bile flow. Dimethylethanolamine pretreatment significantly counteracted the reduction of membrane fluidity (p less than 0.001), the cholesterol enrichment and the inhibition of Na+,K(+)-ATPase (p less than 0.05) promoted by estradiol 17 beta-D-glucuronide administration in all membrane subfractions 30 and 180 min after administration. In addition, dimethylethanolamine-pretreated rats had more polyunsaturated fatty acids in membrane phosphatidylcholine with respect to the control groups. Dilatation of canaliculi and loss of microvilli were evident in estradiol 17 beta-D-glucuronide controls 180 min after estradiol 17 beta-D-glucuronide administration.(ABSTRACT TRUNCATED AT 400 WORDS)
Cytoskeletal function in CD8- and T cell receptor-mediated interaction of cytotoxic T lymphocytes with class I protein.
Authors: A M O'Rourke, J R Apgar, K P Kane, E Martz, M F Mescher
Journal: The Journal of Experimental Medicine (1991)

Cloned allospecific cytolytic T lymphocytes (CTL) adhere to purified class I alloantigen immobilized on plastic and degranulate in response to it. Binding and degranulation are inhibited by drugs that impair cytoskeletal function. Cytochalasins D and E, which interfere with microfilament function, and colchicine, which disrupts microtubules, were used and gave qualitatively similar results. Concentrations of these drugs that inhibited degranulation in response to alloantigen did not inhibit response to immobilized anti-T cell receptor (TCR) antibody. Neither did they inhibit response when alloantigen was co-immobilized with an antibody against class I on the CTL to promote adhesion between the CTL and antigen-bearing surface. Thus, neither transmembrane signal generation via the TCR nor degranulation per se were prevented. Instead, the drugs act to prevent the initial adhesion to alloantigen. CTL binding to alloantigen depends in part on CD8-class I interaction, and adhesion via CD8 is "activated" by crosslinking the TCR with soluble anti-TCR antibody. This adhesion, too, is shown to be cytoskeleton dependent.
First American Electrocardiography
Authors: G. E. Burch
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Chapman's interesting letter reflects considerations expressed to us previously by others. Our facts are expressed in Dr. A. E. Cohn's letter as published in our book A History of<i>Electrocardiography</i>. Dr. Cohn's electrocardiograph was brought to the United States in the fall of 1909 on the SS Adriatic. It is unlikely that both Dr. Cohn's and Dr. Barker's electrocardiographs were on the same boat. Unless this was the case, only<i>one</i>instrument reached America first and to this instrument that priority rightfully belongs. The time of arrival of Dr. Cohn's electrocardiograph in America is beyond doubt. From conversations and correspondence with many people, including Dr. Francis Dieuaide, we are satisfied that Dr. Barker's instrument reached America after Dr. Cohn's. Dr. Chapman's recommendation of dual priority is an unsatisfactory compromise. He knows very well that a dispute over a historical fact cannot be settled by a vote. Furthermore,
Red Blood Cell Gastrointestinal Bleeding Scintigraphy
Authors: ROBERT A. CAMELE, S K BANSAL, ELLIOTT H. TURBINER
Journal: Clinical Nuclear Medicine (1984)

A case report is presented describing visualization of the left ovarian vein during technetium-99m labeled red blood cell (Tc-99m RBC) gastrointestinal scintigraphy. It demonstrates the usefulness of early dynamic images in differentiating the left ovarian vein from activity within the left ureter that may occur secondary to excretion of free technetium. The left ovarian vein may be visualized during Tc-99m RBC gastrointestinal scintigraphy and should not be mistaken for aberrant vasculature.
Effect of discussion and deliberation on the public's views of priority setting in health care: focus group study
Authors: P. Dolan, R. Cookson, B. Ferguson
Journal: BMJ (1999)

<h3>Abstract</h3> <b>Objective</b>: To investigate the extent to which people change their views about priority setting in health care as a result of discussion and deliberation. <b>Design</b>: A random sample of patients from two urban general practices was invited to attend two focus group meetings, a fortnight apart. <b>Setting</b>: North Yorkshire Health Authority. <b>Subjects</b>: 60 randomly chosen patients meeting in 10 ugroups of five to seven people. <b>Main outcome measures</b>: Differences between people9s views at the start of the first meeting and at the end of the second meeting, after they have had an opportunity for discussion and deliberation, measured by questionnaires at the start of the first meeting and the end of the second meeting. <b>Results</b>: Respondents became more reticent about the role that their views should play in determining priorities and more sympathetic to the role that healthcare managers play. About a half of respondents initially wanted to give lower priority to smokers, heavy drinkers, and illegal drug users, but after discussion many no longer wished to discriminate against these people. <b>Conclusion</b>: The public9s views about setting priorities in health care are systematically different when they have been given an opportunity to discuss the issues. If the considered opinions of the general public are required, surveys that do not allow respondents time or opportunity for reflection may be of doubtful value.
Surface and Volume Three-Dimensional Displays of Tc-99m HMPAO Brain SPECT Images in Stroke Patients by a Three-Headed Gamma Camera
Authors: WEI-JEN SHIH, R E SCHLEENBAKER, V STIPP, S MAGOUN, J T SLEVIN
Journal: Clinical Nuclear Medicine (1993)

Twenty patients with strokes were studied to evaluate volume and surface three-dimensional (3D) displays in Tc-99m HMPAO brain SPECT imaging using a triplehead gamma camera interfaced with a 64-bit super computer. In each patient, after an intravenous injection of 20 to 30 mCi of Tc-99m HMPAO, a first-pass cerebral flow study and brain SPECT images at 30 to 60 minutes were obtained. Although the cerebral lesion was more clearly delineated with surface 3D and volume 3D, crossed cerebellar diaschisis in seven patients was more clearly exhibited by volume 3D rather than surface 3D imaging. Volume and surface 3D displays enhance continuity of structures and understanding of spatial relationships; these displays view the brain from all angles, and thus the location and extension of lesion(s) in the brain are much easier to appreciate. It is concluded that 1) both surface and volume 3D displays equally enhance SPECT interpretation; and 2) volume 3D display enhances demonstration of crossed cerebellar diaschisis, but surface 3D display does not.
THE USE OF PENICILLIN IN THE LOCAL TREATMENT OF PNEUMOCOCCAL EMPYEMA 12
Authors: William S. Tillett, James E. McCormack, Margaret J. Cambier
Journal: Journal of Clinical Investigation (1945)

In a previous article (1), results were presented concerning the use of penicillin, injected intra- pleurally, in the treatment of pneumococcal em- pyema.The method of treatment, its effect on the clinical course of the disease, and the final out- come were described in 8 patients.In 7 of them, the infection was eradicated and the suppurative process cleared completely without requiring more than repeated medical thoracenteses for drainage.In 1 patient, a child of 2 years of age, surgical drainage by rib resection was employed when a relapse of the infection occurred shortly after ces- sation of the first injections of penicillin.It is the purpose of the present article to supple- ment the previous report by adding the results obtained from 13 additional cases of pneumococcal empyema, which have been successfully treated in a similar manner.Pertinent features of the recent cases, hitherto unreported, will be described in the text of this article and, in addition, data from the total of 21 cases will be consolidated and discussed on the basis of the larger experience.Patients used for study.In 19 of the patients, the empyema occurred in a typical manner as a complication of lobar pneumonia.In the remain- ing 2, the history suggested that the empyema had developed from a bronchopleural fistula which occurred in association with an acute pneumonitis.Two of the patients had long-standing pulmo-
Haloperidol secreted in breast milk.
Authors: L J Whalley, P G Blain, J K Prime
Journal: BMJ (1981)

A nursing mother was given haloperidol 5 mg twice daily for puerperal psychosis and continued to breast feed under hospital supervision. Despite considerable amounts of haloperidol being secreted in the breast milk (up to 23.5 micrograms/l), the infant was apparently not sedated, fed well, and continued to thrive. The findings suggest that maternal ingestion of haloperidol for short periods has no deleterious effect on the infant9s development.
Progression of left atrial volume index in a population at risk for heart failure: a substudy of the STOP‐HF (St Vincent's Screening TO Prevent Heart Failure) trial
Authors: Patrick Collier, Chris J. Watson, Deidre F. Waterhouse, Ian R. Dawkins, Anil K. Patle, Stephen Horgan, Carmel M. Conlon, Rory O'Hanlon, John A. Baugh, Mark T. Ledwidge, Kenneth McDonald
Journal: European Journal of Heart Failure (2012)
Ethylene Glycol Poisoning
Authors: Charles D. Peterson, Allan J. Collins, Jon Marc Himes, Milton L. Bullock, William F. Keane
Journal: New England Journal of Medicine (1981)

THE treatment of patients with ethylene glycol poisoning includes both hemodialysis and ethanol.1 2 3 However, there are no data on the pharmacokinetics of ethylene glycol in human beings or on the changes in these kinetics effected by therapy. In a patient who ingested a potentially lethal dose of this toxin, serial determinations of ethylene glycol before and during these therapeutic interventions allowed us to calculate these data. In addition, we determined the oral doses of ethanol needed to achieve effective enzymatic blockade of ethylene glycol metabolism during the various phases of therapy.Case ReportA 51-year-old, 75-kg man with no history . . .