tbuckley/cabot-search huggingface dataset:
Effect of filming projection and interobserver variability on angiographic biplane left ventricular volume determination.
Authors: W J Rogers, L R Smith, W P Hood, J A Mantle, C E Rackley, R O Russell
Journal: Circulation (1979)

Although biplane right anterior oblique-left anterior oblique (RAO/LAO) quantitative left ventricular (LV) angiography is commonly performed, justification of LV volume calculation using the area length method (originally formulated from anteroposterior-lateral (AP/LAT) angiograms) has been limited. To assess whether RAO/LAO and AP/LAT LV volumes are similar when computed by the area length method formula, we performed biplane cine LV angiography in both RAO/LAO and AP/LAT projections in random sequence in 21 patients and four LV models of known volume. LV silhouettes were drawn independently by two trained observers. Calculated angiographic volume of the models correlated almost exactly with their true volume (r = 0.999), establishing the absolute accuracy of this system. Rotation of the LV models through 90 degrees of obliquity at 10 degree increments demonstrated a mean change from true volume of only -5.4 +/- 0.7% (p less than 0.001). In the patient studies, rotation to the 30 degree RAO/60 degree LAO position was associated with significant changes in magnitude of biplane areas and long axes, but area length volume estimates were unchanged. Excellent correlation was found between area length calculated AP/LAT and RAO/LAO volumes with r = 0.90, 0.97, and 0.91 for end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF), respectively. Furthermore, interobserver agreement in volume assessment was excellent, with r = 0.98, 0.99, and 0.94 between observers for EDV, ESV, and EF, respectively. Interobserver and inter-method variability for estimates of LV volume and EF ranged from 5--10%. We conclude that when using RAO/LAO LV angiography, volume calculation by the area length method is justified.
Ampicillin Dosage and Use of Prednisolone in Treatment of Pneumonia: Co-operative Controlled Trial
Authors: V. U. McHardy, M. E. Schonell
Journal: BMJ (1972)

A controlled trial was carried out to investigate whether the rate of recovery from pneumonia treated with ampicillin is dose related. Sixty-three patients received 1 g ampicillin daily and 63 received 2 g ampicillin daily for seven or 14 days depending on the rate of response. Twenty patients in each of these groups received, in addition, 20 mg prednisolone daily for seven days. The treatment groups were comparable and the results of treatment were similar in the four groups. The only difference which was of statistical significance was that a larger proportion of patients receiving 1 g ampicillin daily became afebrile within one week. All the ampicillin rashes occurred in the patients receiving 2 g ampicillin daily with and without prednisolone. Ampicillin 1 g daily appears to be adequate dosage in the treatment of pneumonia, and the rate of recovery has not been shown to be accelerated by using 2 g. No deleterious effects were noted with additional prednisolone therapy and this appeared to increase the rate at which the patients became afebrile, although the figures were not statistically significant.
TENNESSEE STATE MEDICAL ASSOCIATION
Authors: O. Dulaney
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transmission of Syphilis by Blood Transfusion
Authors: J. A. W. McCluskie
Journal: BMJ (1939)

MDCL ORA indirect inguinal hernia.At operation the condition conformed in every way to that in Case 1, and it was treated in the same manner, except that silk was used to repair the hole in the transversalis fascia, and a silk darning-repair made of the inguinal canal.His recovery was uninterrupted.-,/,rm oLE .. ', HtMIALlC 4
A nudge in the right direction for organ donation--but is it enough?
Authors: H. Wellesley
Journal: BMJ (2011)

Applicants for a UK driving licence are now asked to decide whether to join the NHS Organ Donor Register. <b>Hugo Wellesley</b> argues that although this should boost the number of people on the register, the number of people who ultimately donate organs will not rise unless we act to increase people's underlying willingness to donate
1162 ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN INTERFERON STIMULATED GENES WITH CHRONIC HEPATITIS C TREATMENT OUTCOME
Authors: R. Lopez-Rodriguez, M. Roman, Á. Hernández-Bartolomé, M.J. Borque, F. Abad-Santos, Y. Rodríguez-Muñoz, S. Martin-Vilchez, M. Trapero-Marugán, L. Rodrigo, P. Muñoz de Rueda, J. Salmeron, R. Moreno-Otero, P. Sanz-Cameno
Journal: Journal of Hepatology (2011)
Biofeedback: Behavioral Medicine
Authors: Seymour Diamond
Journal: JAMA (1974)

In a field that has suffered because of false and misleading claims and commercial exploitation, it is refreshing to find a book that will put biofeedback in its proper perspective for the practicing physician. Mathematician Norbert Weiner, who coined the term, defined feedback as "a method of controlling the system by reinserting into it the results of its past performance." Biofeedback is accomplished when a biological system is mediated by man-made detections, amplification, and display instruments. The development of instrumental techniques that can bring previously involuntary bodily activities under voluntary control represents a major new frontier for clinical medicine and psychiatry. The book is divided into 13 chapters written by various pioneers in the field. The opening chapters provide an adequate introduction and scientific orientation for the physician who has no previous knowledge of biofeedback, and the sections on clinical applications will whet the interest of those who are psychologically
Tubercles of the Choroid
Authors: R. S. Illingworth, T. Wright
Journal: BMJ (1948)

<h3>Abstract</h3> <i>Escherichia coli</i> is a Gram-negative bacterium that colonizes the human intestine and virulent strains can cause severe diarrhoeal and extraintestinal diseases. The protein SslE is secreted by a range of pathogenic and some commensal <i>E. coli</i> strains. It can degrade mucins in the intestine, promotes biofilm maturation and it is a major determinant of infection in virulent strains, although how it carries out these functions is not well understood. Here we examine SslE from the <i>E. coli</i> Waksman and H10407 strains and reveal that it has a novel and dynamic structure. In response to acidification within mature biofilms we show how SslE forms a unique functional aggregate that interacts with cellulose and regulates the distribution of exopolysaccharides in macrocolony biofilms. Our data indicates that the spatial organization of SslE polymers and local pH are critical for biofilm maturation and SslE is a key factor that drives persistence of SslE-secreting bacteria during acidic stress.
A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
Authors: Judith E. Karp, Rebecca M. Ricklis, Kumudha Balakrishnan, Janet Briel, Jacqueline Greer, Steven D. Gore, B. Douglas Smith, Michael A. McDevitt, Hetty Carraway, Mark J. Levis, Varsha Gandhi
Journal: Blood (2007)
LEFT BUNDLE BRANCH BLOCK BENIGN?
Authors: SANDERS T. FRANK
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 August 1969LEFT BUNDLE BRANCH BLOCK BENIGN?SANDERS T. FRANKSANDERS T. FRANKSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-2-431 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In regard to the article on "Benign Left Bundle Branch Block" by Dr. Beach and co-workers (Ann. Intern. Med. 70: 269, 1969), I have recently had under my care a similar patient with at least a 15-year follow-up. This patient, a 54-year-old Air Force Colonel, has been known to have left bundle branch block for at least 15 years (since his first electrocardiogram). He has been evaluated several times, felt to be free of cardiac disease, and allowed to continue his military service.In early April 1969 he noted the insidious onset of dyspnea and coughing that...References1. BOURASSOBOITEAUALLENSTEIN MGGMBJ: Hemodynamic studies during intermittent left bundle branch block. Amer. J. Cardiol. 10: 792, 1962. CrossrefMedlineGoogle Scholar2. JOHNSTONMULLINSGUPTAMITCHELL RRCBDNJH: Effect of intermittent right bundle branch block in right ventricular contractility. Amer. J. Cardiol. 17: 813, 1966. CrossrefGoogle Scholar3. KOSOWSKYSCHERLAGDAMATO BDBJAN: Re-evaluation of the atrial contribution to ventricular function. Amer. J. Cardiol. 21: 518, 1968. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SANDERS T. FRANKAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1969Volume 71, Issue 2Page: 431-432KeywordsArmed forcesCoughingDyspneaElectrocardiographyHeart diseasesLeft bundle branch blockPatients ePublished: 1 December 2008 Issue Published: 1 August 1969 PDF downloadLoading ...
FIVE YEAR EXPERIENCE WITH RADIOACTIVE IODINE IN TREATMENT OF HYPERTHYROIDISM
Authors: D. E. Clark
Journal: JAMA (1952)

Since Hertz and Roberts,<sup>1</sup>and Hamilton and Lawrence<sup>2</sup>reported in 1942 on the first patients with thyrotoxicosis treated with radioactive iodine, successful remissions have been obtained in a large number of patients with hyperthyroidism using this isotope. The results of treatment have established a definite place for radioactive iodine (I<sup>131</sup>) in the treatment of selected cases. At present over 130 hospitals and clinics<sup>3</sup>are using I<sup>131</sup>for such cases. During the past five years we have had an opportunity to institute therapy in approximately 500 cases of primary or secondary hyperthyroidism. The purpose of this paper is to report our experiences in the management of 384 patients who have been followed for a period of from 6 months to approximately 60 months and whose therapy has been completed. <h3>SELECTION OF PATIENTS</h3> There are some differences among groups of investigators who are using radioactive iodine in
Molecular Pathways: GLI1-Induced Drug Glucuronidation in Resistant Cancer Cells
Authors: Hiba Ahmad Zahreddine, Katherine L.B. Borden
Journal: Clinical Cancer Research (2015)

Abstract Drug resistance remains a major impediment in the development of durable cancer therapies. Studies in acute myelogenous leukemia (AML) patients revealed a new form of multidrug resistance. Here, increased glioma-associated protein GLI1 leads to elevation of the UDP-glucuronosyl transferase (UGT) enzymes. UGTs add glucuronic acid to xenobiotics and metabolites. Traditionally, the loss of these enzymes is thought to contribute to cancer as a result of impaired clearance of environmental carcinogens. However, we demonstrate that overexpression of UGTs can contribute to oncogenesis by promoting drug resistance. Indeed, UGT levels in AML patients treated with ribavirin and/or cytarabine were elevated at relapse relative to diagnosis. This was reversed by GLI1 inhibition, suggesting a clinically relevant strategy to overcome drug resistance. Further, overexpression of UGTs can also lead to drug resistance in other cancers, such as certain Hsp90 inhibitors and vorinostat in colorectal and chronic lymphoblastic leukemia, respectively. Not all drugs are targets of glucuronidation, suggesting that UGT status could be relevant to treatment choice. Here, we describe several facets of UGT biology and how these could be exploited clinically. These studies demonstrate how drugs in cancer cells can be metabolized differentially than their normal counterparts. In summary, we describe a new form of drug resistance relevant to a variety of cancer contexts. Clin Cancer Res; 21(10); 2207–10. ©2015 AACR.
Occupational allergic contact dermatitis and major allergens in France: temporal trends for the period 2001-2010
Authors: L. Bensefa-Colas, M. Telle-Lamberton, C. Paris, S. Faye, S.J. Stocks, A. Luc, J.-L. Bourrain, M.-N. Crépy, D. Dupas, P. Frimat, R. Garnier, M.-P. Lehucher-Michel, J.-C. Pairon, J.-M. Soulat, G. Lasfargues, D. Choudat, I. Momas
Journal: British Journal of Dermatology (2014)

Occupational allergic contact dermatitis (OACD) is one of the most common occupational skin diseases in developed countries, but data about its temporal trends in incidence remain sparse.The aim of this study is to describe OACD trends in terms of industrial activities and main causal agents in France over the period 2001-2010.Data were collected from the French National Network of Occupational Disease Vigilance and Prevention (RNV3P, Réseau National de Vigilance et de Prévention des Pathologies Professionnelles). All OACD considered probably or certainly associated with an occupational exposure were included in the study. Trends were examined (i) on annual crude numbers of OACD and (ii) on reported odds ratios of OACD calculated using logistic regression models.Overall, 3738 cases of OACD were reported and the mean age of OACD cases was 35 years, 52% being women. The most frequent occupations were hairdressers, health care workers, cleaning staff and masons. The total number of OACD cases remained stable over the study period, but increases in OACD related to isothiazolinones (P = 0·002), epoxy resins (P = 0·012) and fragrances (P = 0·005) were observed. Conversely, decreases were noted for cement compounds (P = 0·002) and plant products (P = 0·031). These trends highlight specific sectors and exposures at risk of OACD.Trends in OACD depend on the nature of exposure. Observed decreases were consistent with prevention measures taken during the study period, and the increases observed serve to highlight those areas where preventative efforts need to be made to reduce skin allergies in the workplace.
Which is the best way to analyze the efficacy of albumin dialysis in hepatic encephalopathy?
Authors: Rafael Bañares, Agustín Albillos, María‐Vega Catalina
Journal: Hepatology (2008)

We read with interest the article by Hassanein et al.1 and the editorial comments by Ferenci and Kramer2 regarding the use of albumin dialysis for the treatment of advanced hepatic encephalopathy (HE). Surprisingly, the interpretations of the results of the trial were quite contradictory. Although the authors describe a positive relevant effect of albumin dialysis for this indication, the criticisms mentioned in the editorial, mainly referring to the use of nonstandardized tools to assess HE and the outcome of patients after therapy, indicate that "at present, the data do not reveal any major benefit of extracorporeal albumin dialysis in the management of patients with liver failure". We disagree with this last comment for the following reasons: (1) The response to therapy was clearly defined and the evaluation tools established at the time of the trial design, and methodological procedures were carefully conducted during the trial; (2) The use of new approaches for the evaluation of HE seems reasonable considering that, as the authors mention, there is no widely used scale in this setting. Moreover, the outcome measures implemented in the trial consider maintenance of the treatment effect through time such that any improvement in HE will also be identified. It is important to emphasize that the trial was neither designed nor powered to detect differences in survival. Thus, failure of albumin dialysis to reduce mortality does not necessarily translate to failure of the experimental arm; (3) The results of this trial are in agreement with previous studies assessing albumin dialysis in which improvements in both relevant physiopathological variables3, 4 and clinical outcomes, including survival,5 have been noted; (4) Finally, we believe that the results of this trial should be analyzed not only in the context of treatment efficacy but should also be considered for their potential contribution in the design of new hypotheses, the selection of a more adequate target population, etc. In addition, it is important to remark that the use of albumin dialysis in severely affected patients was associated with no significant safety problems. From this perspective, we believe that the results of the trial by Hassanein et al. are truly encouraging and support ongoing large-scale randomized trials with major applications for the future development of artificial liver support in the treatment of liver failure. Rafael Bañares* , Agustín Albillos ?, María-Vega Catalina* , * Liver Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain, Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain, Universidad Complutense de Madrid, Madrid, Spain, ? Department of Gastroenterology, Hospital Universitario Ramon y Cajal, Universidad de Alcalá, Madrid, Spain.
Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer
Authors: Kaoru Nishikawa, Tomohiro Asai, Hirokazu Shigematsu, Kosuke Shimizu, Hisakazu Kato, Yoshihiro Asano, Seiji Takashima, Eisuke Mekada, Naoto Oku, Tetsuo Minamino
Journal: Journal of Controlled Release (2011)
Faecal Incontinence and Related Problems in the Older Adult
Authors: T. M Thomas
Journal: BMJ (1994)

James A Barrett Arnold, pounds sterling 30, pp 216 ISBN 0-340-54361-2

Although there is widespread acknowledgment that with better bowel management faecal incontinence in the elderly can be reduced to a minimum, the condition remains a “heart sink” for professionals as well as for sufferers and their carers. Consequences …
The Role of Parental Cognitive, Behavioral, and Motor Profiles in Clinical Variability in Individuals With Chromosome 16p11.2 Deletions
Authors: Andres Moreno-De-Luca, David W. Evans, K. B. Boomer, Ellen Hanson, Raphael Bernier, Robin P. Goin-Kochel, Scott M. Myers, Thomas D. Challman, Daniel Moreno-De-Luca, Mylissa M. Slane, Abby E. Hare, Wendy K. Chung, John E. Spiro, W. Andrew Faucett, Christa L. Martin, David H. Ledbetter
Journal: JAMA Psychiatry (2014)

Most disorders caused by copy number variants (CNVs) display significant clinical variability, often referred to as incomplete penetrance and variable expressivity. Genetic and environmental sources of this variability are not well understood.
Clinical Outcomes After Bilevel Positive Airway Pressure Treatment for Acute Asthma Exacerbations
Authors: Christopher Golden, Meng Xu, Cristina M. Estrada, Donald H. Arnold
Journal: JAMA Pediatrics (2014)

Guidelines for the management of acute asthma exacerbations recommend noninvasive ventilation as an "experimental approach for treatment of respiratory failure due to severe asthma exacerbation." 1(p398) Clinicians in our tertiary pediatric emergency department have the option to use bilevel positive airway pressure (BiPAP) as treatment for children with asthma exacerbations who have no signs of respiratory failure.We sought to examine whether these patients have improved clinical outcomes.Methods | The study protocol was approved by the institutional review board of Vanderbilt University.Written informed consent was obtained from the parents and verbal assent from the participants.We performed a secondary analysis of data (which were not deidentified) from a prospective observational study of 933 children and adolescents aged 5 to 17 years who were admitted to our pediatric emergency department with acute asthma exacerbations.The objective of the
Pneumococcal vaccination: current and future issues
Authors: Å. Örtqvist
Journal: European Respiratory Journal (2001)

Infection with Streptococcus pneumoniae remains a major global health burden meaning the development of effective vaccines is urgently needed. The current 23-valent polysaccharide vaccine has been shown to prevent pneumococcal pneumonia in immunocompetent young adults, but not in elderly persons. However, in prevention of invasive pneumococcal disease, the vaccine is efficacious in the elderly and may also be effective in some groups of immunocompromised patients. The polysaccharide vaccine is, therefore, recommended in all older (≥55–65 yrs of age) adults and in young children (&gt;2 yrs of age) who have a high risk for pneumococcal disease. Revaccination can be safely performed and is recommended 5 yrs after the first dose. In children &lt;2 yrs of age, the new polysaccharide-protein conjugate vaccines, including 7–11 serotypes, seem to be effective in the prevention of invasive disease, severe pneumonia and serotype-specific (and vaccine-related types) otitis media. The low serotype coverage, need for repeated doses, and high price, may decrease the usefulness of the new conjugates. However, the included serotypes correspond to those most often associated with penicillin resistance and vaccination is, therefore, a possible tool in limiting the spread of antibiotic-resistant pneumococci.
MPs call for English hospitals to publish productivity rates
Authors: Andrew Cole
Journal: BMJ (2011)

The House of Commons Public Accounts Committee wants all hospitals in England to publish their year on year clinical productivity rates as part of the drive to find £20bn (€23bn; $32bn) of efficiency savings in the NHS by 2014-15.

It is also calling for the Payments by Results scheme, by which hospitals are paid per procedure, to cover all their activities and for better use of pay contracts to boost staff performance.

Its latest report is a response to a report by the National Audit Office last year showing that hospital productivity fell by 1.6% a year between 2000-1 and 2010-11 despite a record increase in annual NHS …
TCT-815 Treatment of Functional Mitral Regurgitation by Percutaneous Annuloplasty Using the Carillon Mitral Contour System Results in Improved Clinical Efficacy – The TITAN II Study
Authors: Michael Haude, Hubertus Degen, Tomasz Siminiak, Piotr Kalmucki, Horst Sievert, Jochen Müller-Ehmsen, Benjamin Krausgrill, Janusz Lipiecki
Journal: Journal of the American College of Cardiology (2014)