tbuckley/cabot-search huggingface dataset:
Collaborative Care for Post-CABG Depression—Reply
Authors: Bruce L. Rollman
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Successful Case of Loreta's Operation on the Stomach
Authors: F. Treves
Journal: BMJ (1889)

opinion it did not give good results.As Musser, of Philadelphia.in his paper entitled " Oil of Eucalyptus in some Malarial Affections," seemed to show that the drug is useful in certain febrile states, I made a number of observations with the medicine in Malta fever.In the cases in which it was given it was always well borne, and as it is said to act as an antiseptic, carminative, and stimulating expectorant, further experience may prove it to be really beneficial.My own opinion is that it has no effect on the course of the fever.
Fetal Monitoring and Neonatal Death Rates
Authors: Andre E. Hellegers
Journal: New England Journal of Medicine (1978)

The study by Neutra et al. in this issue of the Journal continues a debate that has been ongoing in this decade. It concerns the value of electronic fetal monitoring in labor. The issue was recently the subject of hearings before a Senate subcommittee.In theory electronic fetal heart monitoring makes good sense. Before its development the fetal heart rate was examined with a fetoscope. Rates of less than 100 or more than 160 per minute were held to denote fetal distress. It was also realized that compression of the fetal head, as during labor contractions, could slow the fetal . . .
Force, velocity of shortening and sarcomere length in cardiac muscle
Authors: H E D J T. KEURS, B WOHLFART, L RICCIARDI, B J M MULDER, J J J BUCX, A VAN DER LAARSE
Journal: Cardiovascular Research (1985)

Force, velocity of shortening and sarcomere length in cardiac muscle Get access H E D J TER KEURS, H E D J TER KEURS **From the University of Calgary, Canada, Search for other works by this author on: Oxford Academic PubMed Google Scholar B WOHLFART, B WOHLFART ††University of Lund, Sweden. Search for other works by this author on: Oxford Academic PubMed Google Scholar L RICCIARDI, L RICCIARDI ‡‡University of Pavia, Italy, Search for other works by this author on: Oxford Academic PubMed Google Scholar B J M MULDER, B J M MULDER §§University of Leiden, The Netherlands, Search for other works by this author on: Oxford Academic PubMed Google Scholar J J J BUCX, J J J BUCX Search for other works by this author on: Oxford Academic PubMed Google Scholar A VAN DER LAARSE A VAN DER LAARSE §§University of Leiden, The Netherlands, Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 19, Issue 9, September 1985, Page 518, https://doi.org/10.1093/cvr/19.9.518 Published: 01 September 1985
DEFLEXION ATTITUDES IN BREECH PRESENTATION
Authors: IRVING F. STEIN
Journal: JAMA (1941)

The management of breech presentation has received considerable attention in recent obstetric literature and various plans for delivery have been described with a view to improvement in results. In these contributions, the attack on common practice has been directed against unwarranted haste, premature traction, the abuse of cesarean section and the necessity of anesthesia. All these criticisms, I believe, are on a rational basis. It has been more or less accepted by many authorities on obstetrics that breech presentation is merely a reversed cephalic presentation which can be readily turned by external manipulation, thus obviating the difficulties so often encountered during delivery. Efforts to avoid breech extraction appear to be warranted in view of the fact that the fetal mortality in delivery by breech extraction is from three to five times that by vertex extraction and has been estimated by Rulison1to claim 14,000 babies annually in the United
β3 Integrin Subunit Mediates the Bone-Resorbing Function Exerted by Cultured Myeloma Plasma Cells
Authors: Marco Tucci, Raffaele De Palma, Lucia Lombardi, Gabriella Rodolico, Liberato Berrino, Franco Dammacco, Franco Silvestris
Journal: Cancer Research (2009)

alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells from patients with no evidence of bone disease. We therefore explored the alpha(v)beta(3) transcriptional pathway in the bone-resorbing cells. Silencing of beta(3) chain abrogated the ability to produce erosion pits and extracellular signal-regulated kinase 1/2 phosphorylation resulting in the defective function of cFos and nuclear factor activator T cell 1, the terminal effectors of osteoclast activation. A similar defect occurred in constitutively beta(3)-deficient cells from patients with no skeleton disease. Microarray gene analysis of beta(3)(+) myeloma cells showed that several osteoclast-related genes were up-regulated. Their functions include the activation of receptor pathways beta(3) and c-fms that regulate several osteoclast functions. These data emphasize the postulated role of myeloma cells in multiple myeloma bone disease and suggest that their osteoclast-like activity is regulated, at least in vitro, by the beta(3) subunit of the integrin.
VALUE OF CARBON TETRACHLORID AS AN ANTHELMINTIC
Authors: J. F. DOCHERTY
Journal: JAMA (1923)

From a published report on the use of carbon tetrachlorid as an anthelmintic in the treatment of ancylostomiasis one is led to conclude that as such it is more efficacious than any of the other three drugs in general use in hookworm campaigns. In this report an attempt has been made to make a comparative estimate of the value of the four vermifuges thymol, betanaphthol, chenopodium and carbon tetrachlorid, definite fixed doses of each being used. An absolute control of persons under treatment was necessary. Three hundred prisoners in two of the island jails were selected with their own consent and with the permission and assistance of the superintendent of prisons; of these, 215 completed the prescribed course of treatment, the remainder falling out on account of discharge, illness and personal objections. The men selected were those who had been exposed to hookworm infection previous to imprisonment and who had
236 SELECTIVE INTRAHEPATIC ARTERIAL INFUSION OF AN ENDOTHELIN-A (ET-A)-RECEPTOR INHIBITOR INCREASES THE HEPATIC ARTERIAL FLOW AND DECREASES THE PORTAL VENOUS PRESSURE IN DECOMPENSATED CIRRHOTIC PATIENTS
Authors: A. Zipprich, M.M. Dollinger, M. Winkler, G. Kleber, W.E. Fleig
Journal: Journal of Hepatology (2009)
Dame Cicely Saunders
Authors: Caroline Richmond
Journal: BMJ (2005)

Founder of the modern hospice movementCicely Saunders founded the first modern hospice and, more than anybody else, was responsible for establishing the discipline and the culture of palliative care.She introduced effective pain management and insisted that dying people needed dignity, compassion, and respect, as well as rigorous scientific methodology in the testing of treatments.St Christopher's Hospice opened in south west London in 1967.It is now one of many but is still the leader in the field.It was her personal achievement and has been imitated all over the world.She raised the funds for the hospice and contributed some of her own money.Saunders introduced the idea of "total pain," which included the physical, emotional, social, and spiritual dimensions of distress.A good listener, she paid systematic attention to patient narratives.One St Christopher's patient, transferred from another hospital, said, "They used to see how long I could go without an injection.I used to be pouring with sweat because of the pain.I couldn't speak to anyone and I was having crying fits.I think I've only cried once since I've been here . . .The biggest difference is feeling so calm.I don't get worked up or upset."Cicely Mary Strode Saunders was born in Barnet, Hertfordshire, in 1918.She was sent to Roedean School when she was 10.Taller than the other girls, she felt she never fitted in, which, she said, gave her a feeling for people who were outsiders.She also suffered from a painful and slightly crooked spine, and was made to lie flat on the floor for 40 minutes a day.Her father disapproved of her desire to be a nurse, and so instead she went to study at Oxford.After the outbreak of the second world war she abandoned her course and defied her parents' advice, enrolling as a student nurse at St Thomas' Hospital in 1944.However, her back was still painful, and she was advised to quit nursing.After returning to Oxford for a year she gained a "war degree" and qualified as a social worker, or what was then called a lady almoner, in 1947.Saunders was originally an agnostic, but, while on holiday in Cornwall with some
The Revision of the U. S. Pharmacopœia of 1890.
Authors: D. Benjamin
Journal: JAMA (1890)

<h3>To the Editor:</h3> —Please find herein enclosed, a copy of report, by me, as Chairman of the Committee from this State, to Convention for Revision of U. S. P. 1890, held at Washington, D. C., May 7-10, and delivered to New Jersey State Medical Society June 11th. As I think the report contains matter of importance to the entire medical profession, it is submitted to you; and I would say that it is my opinion the American Medical Association should take decidedly more interest in the work of the Convention. Very truly yours, Camden, N. J., June 12, 1890.
The ARTIFICIAL FEEDING of CHILDREN
Authors: A. Macphail
Journal: BMJ (1896)

In January, 1895, she noticed a swelling in the ]eft groin, growing at first slowly, and then rapidly.Her general health was now giving way.She had much difficulty in sitting down from pain in the back, which was much increased when rising from a chair; no pain when seated.During this time she had had no treatment.She came to my out-patients in April, x895, complaining of a large swelling, occupying the position of a psoas abscess.There was no spinal angularity no pain over the lumbar region, and no abnurmality about the hip-joint.She further complained of losing weight, of pain of a gnawing, aching character over the left buttock, close to the spine.This was increased on pressure of the ilia together or apart.The swelling in the thigh did not alter its shape or position on flexion of the legg; it Bad no impulse on coughing, but had a tense, deep sense of fluctuation.The circumference of the leg was 2 inches greater than that of its fellow.Patient walked slightly lame, with short steps.On point pressure over thb sacro-iliac joint she complained of sickening pain.She could not lie
THE HEMODYNAMICS OF THYROTOXICOSIS IN MAN WITH SPECIAL REFERENCE TO CORONARY BLOOD FLOW AND MYOCARDIAL OXYGEN METABOLISM 1
Authors: George G. Rowe, John H. Huston, Arvin B. Weinstein, Herman Tuchman, John F. Brown, Charles W. Crumpton, Audrey Peterson, Beryl Welch, Phyllis Fosshage
Journal: Journal of Clinical Investigation (1956)
Standards in medical research Criticism unjustified and unfair
Authors: W Kelly, M Kelly, R Mahmood, S Turner, K Elliott, I H Lewis
Journal: BMJ (1994)

EDITOR, - We wish to clarify the matter raised in the letter from Ray Jones and colleagues, which was published under the subheading “sloppy use of literature often to blame.”1 Our paper on the influence of social deprivation on illness in diabetic patients2 was prominently cited as an example of sloppy use of the literature.

To make these adverse criticisms of our research is unjustified and partly misdirected for reasons that may not have been apparent. Our article was originally submitted as a full length paper with numerous references. The paper was accepted as a short report and hence was reduced to only 600 words with at most five references; we note that in their letter Jones and colleagues were allowed 17 references, three of which they seem to consider that we had overlooked; two of these, however, were irrelevant to the …
Bad Medicine: Doctors Doing Harm Since Hippocrates
Authors: Iain McClure
Journal: BMJ (2006)

I recently read George Bernard Shaw's The Doctor's Dilemma and experienced an unexpected sense of insult on behalf of my profession. In this celebrated play (see also Editor's choice, BMJ 2 September 2006 (doi: 10.1136/bmj.333.7566.0-f)), Shaw serially indicts various kinds of late 19th century doctor—the hypocrite, the self publicist, and (most dangerous of all) the blinkered zealot. While I admired the plot construction, I suspected that Shaw had created such character extremes for comic effect. However, having read David Wootton's Bad Medicine , I am now no longer insulted and, on behalf of my profession, feel somewhat grateful to Shaw for his restraint. For, as Wootton painstakingly argues in this short but undoubtedly explosive new book, the history of medicine has been nothing less than a failure and doctors have been the culprits.

Although Bad Medicine is short, Wootton has written “three books in one.” In the first part he surveys a tradition of therapy that survived for 2300 …
Prognosis in Nontraumatic Coma
Authors: DAVID E. LEVY
Journal: Annals of Internal Medicine (1981)

We conducted serial neurologic examinations on 500 patients in nontraumatic coma to identify factors predicting recovery. Overall, 81 patients (16%) led an independent life at some point within the first year; the remainder either died without recovery from coma (61%), never improved beyond the vegetative state (12%), or regained consciousness but remained dependent on others for daily activities (11%). Functional recovery did not depend on age but was to some degree related to the cause of coma (subarachnoid hemorrhage and other cerebrovascular disease having the worst recovery; hypoxia-ischemia, intermediate; and hepatic and miscellaneous causes, best) and especially to early clinical signs of brain dysfunction. Even within hours of the onset of coma, only one of 120 patients lacking two of corneal, pupillary, and oculovestibular responses ever regained independent function. The study identifies clinical features of comatose patients that appear within the first week and that are important for predicting recovery and designing future therapeutic trials.
Abstract 347: Gene expression signature of the gross morphology and the specific role of EpCAM in hepatocellular carcinoma
Authors: Shinji Tanaka, Ayano Murakata, Kaoru Mogushi, Mahmut Yasen, Daisuke Ban, Norio Noguchi, Takumi Irie, Atsushi Kudo, Noriaki Nakamura, Johji Inazawa, Hiroshi Tanaka, Shigeki Arii
Journal: Cancer Research (2011)

Abstract Tumor morphologies have been identified to associate with their malignant properties such as the invasive, metastatic and/or even recurrent potentials after the cancer treatment. Hepatocellular carcinoma (HCC) is known to demonstrate a variety of morphological appearances. Eggel's nodular type of HCC is morphologically subclassified into single nodular type (SN), single nodular type with extranodular growth (SNEG), and confluent multinodular type (CM), but their biomolecular differences remain unclear. In this study, the clinicopathologic characteristics as well as genome-wide gene expressions were analyzed in relation to the gross morphology of curatively resected HCC. Among 275 patients with nodular type HCC (124 SN-type, 91 SNEG-type and 60 CM-type), significantly poor prognosis was recognized in CM-type in overall survival (p=0.0020) as well as recurrence-free survival (p=0.0066) after the curative resection. The genome-wide expression patterns were evaluated by 3D principal component analysis using Kruskal-Wallis test, and p-value distribution histograms using Mann-Whitney U test. Both of the analyses on the gene expression signature revealed the significant deference in CM-type HCC compared to either SN or SNEG-type HCC. In particular, a stem cell marker EpCAM was dominantly expressed in CM-type HCC. Immunohistochemical studies confirmed the specific expression of EpCAM in HCC cancer cells of CM-type. In multivariate analysis, the gross morphology of CM type was significantly associated with EpCAM expression (p=0.0133), AFP-L3 level (p=0.0311) and the portal vein invasion (p=0.0138). Furthermore, EpCAM was predictive for poor prognosis in overall and recurrence-free survivals of patients with CM-type HCC (p=0.0082 and p=0.0043, respectively). Our studies suggested the distinct signature of gene expression closely related to the morphological progression in HCC. Especially, EpCAM might play a critical role in the aggressiveness of CM-type HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 347. doi:10.1158/1538-7445.AM2011-347
Increasing incidence of tuberculosis in England and Wales: a study of the likely causes
Authors: N Bhatti, M R Law, J K Morris, R Halliday, J Moore-Gillon
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective</b>: To examine factors responsible for the recent increase in tuberculosis in England and Wales. <b>Design</b>: Study of the incidence of tuberculosis (a) in the 403 local authority districts in England and Wales, ranked according to Jarman score, and (b) in one deprived inner city district, according to ethnic origin and other factors. <b>Setting</b>: (a) England and Wales 1980-92, and (b) the London borough of Hackney 1986-93. <b>Main outcome measure</b>: Age and sex adjusted rate of tuberculosis. <b>Results</b>: In England and Wales notifications of tuberculosis increased by 12% between 1988 and 1992. The increase was 35% in the poorest 10th of the population and 13% in the next two; and in the remaining 70% there was no increase. In Hackney the increase affected traditionally high risk and low risk ethnic groups to a similar extent. In the "low risk" white and West Indian communities the incidence increased by 58% from 1986-8 (78 cases) to 1991-3 (123), whereas in residents of Indian subcontinent origin the increase was 41% (from 51 cases to 72). Tuberculosis in recently arrived immigrants—refugees (11% of the Hackney population) and Africans (6%)—accounted for less than half of the overall increase, and the proportion of such residents was much higher than in most socioeconomically deprived districts. The local increase was not due to an increase in the proportion of cases notified, to HIV infection, nor to an increase in homeless people. <b>Conclusions</b>: The national rise in tuberculosis affects only the poorest areas. Within one such area all residents (white and established ethnic minorities) were affected to a similar extent. The evidence indicates a major role for socioeconomic factors in the increase in tuberculosis and only a minor role for recent immigration from endemic areas. <h3>Key messages</h3> Key messages The increase affected only the poorer areas; in the poorest 10th of the population it was 35% Data from one such area suggest that the increase affected white people, West Indians, and residents of Indian subcontinent origin to a similar extent; the recent entry of refugees was likely to be only a minor factor in the national increase in tuberculosis Socioeconomic factors affecting all residents are likely to be predominantly responsible for the increase in tuberculosis—not factors specific to high risk ethnic minority groups
Diagnosis in a Patient With Acute Diarrhea-Reply
Authors: Terry K. Satterwhite, Herbert L. DuPont
Journal: JAMA (1977)

We thank Drs Morris and Chiprut for their helpful comments and are in complete agreement that proctoscopy is a valuable tool in the examination of a wide spectrum of patients with diarrhea. Our algorithm focused sharply on the patient with infectious diarrhea of less than two weeks' duration, and purposely excluded those with more protracted illnesses. Proctoscopy is useful in establishing the presence of colitis, which may be found in patients with shigellosis, salmonellosis or amebiasis. We feel that the fecal leukocyte test, when combined with stool cultures, is a reasonable way to establish the diagnosis of shigellosis or salmonellosis. Sampling an ulcer through a proctoscope will increase the yield of<i>Entamoeba histolytica</i>in patients with amebiasis. In the patient with chronic or intermittent diarrhea, proctosigmoidoscopy may be the key in the diagnosis of inflammatory bowel disease, radiation colitis, or neoplasm. In this patient, other tests may be
Suicide and "The Befrienders".
Authors: T A Holding
Journal: BMJ (1975)

The short-term effect of "The Befrienders"--an 11-episode weekly series on B.B.C. 1 portraying the Samaritans as a suicide prevention service--on suicide and undetermined deaths was monitored in Edinburgh. No preventive effect was observed though the series was associated with a dramatic rise in new client referrals to the Edinburgh branch of the Samaritans.
Family doctors and innovation in general practice
Authors: N. Bosanquet, B. Leese
Journal: BMJ (1988)

Family doctors have been presented with changes in government policies and incentives in a recent white paper on primary care. Little work has been done, however, to find out how general practitioners respond to such measures. The response of general practitioners to professional and economic incentives was examined in relation to the location of the practice and the characteristics of the practitioners in seven different areas of England. The areas represented urban, rural, affluent, and deprived communities. The overall response rate was 74%, but the response varied among the areas, being poorest (64%) in an inner city area. Practices were subdivided as innovative, traditional, or intermediate, according to whether they employed a nurse and participated in the cost rent scheme and the vocational training scheme. Innovative practices were defined as fulfilling two of these criteria and traditional practices as fulfilling none; the remainder were classed as intermediate. The results showed that these three types of practice had distinct strategies that were related to financial constraints and the local population. Innovative practices had more partners and were often located in rural or affluent suburban areas; traditional practices had fewer partners and were more common in urban and working class areas. Innovative practices seemed to be in the best position to increase their services, and hence their incomes, in response to the recent proposals in the white paper. Practices in areas of developmental difficulty (predominantly urban but not necessarily inner city areas) had been less able to respond to existing incentives and had a smaller margin available for developing their services. In view of the effect of local constraints of economics and population on the strategy of practices, concentrating resources for primary care in local budgets for working class and urban areas may be preferable to extending the system of charging fees for services provided by family doctors.