tbuckley/cabot-search huggingface dataset:
A Study of Unipolar Left Back Leads and Their Application to Posterior Myocardial Infarction
Authors: STEPHEN R. ELEK, LAWRENCE M. HERMAN, GEORGE C. GRIFFITH
Journal: Circulation (1953)

The electrocardiographic diagnosis of myocardial infarction of the posterior wall is often missed because it is largely dependent on lead and because this electrode position often does not subtend the diseased myocardium. To remedy this defect, a new method is described—unipolar left back leads. The validity of this method in registering potential from the posterior left ventricular wall is discussed as well as its importance in the diagnosis of myocardial infarction of the posterior wall. Left back leads can illuminate the significance of questionable Q waves.
Erratum: Corrigendum: Ligand-induced conformational changes allosterically activate Toll-like receptor 9
Authors: Eicke Latz, Anjali Verma, Alberto Visintin, Mei Gong, Cherilyn M Sirois, Dionne C G Klein, Brian G Monks, C James McKnight, Marc S Lamphier, W Paul Duprex, Terje Espevik, Douglas T Golenbock
Journal: Nature Immunology (2007)
On a Preparation of Milk for Diabetic Patients
Authors: S. Ringer
Journal: BMJ (1895)

stage of rodent ulcer.In the end, however, such warts on the lip are apt to degenerate into deeply penetrating epitheliomata.Vascular growths may form on the lip, usually assuming the form of venous nwevi, dark purplish, soft prominences, of the size of half a pea or larger.They are not very uncommon on the underlip of elderly women, cause no subjective set sa- tions, but are disfiguring.They can be dealt with very satisfactorily by electrolysis.
The Role Of Induced Sputum Cytology In Clinical Monitorizing Of Childhood Asthma
Authors: Z. Tamay, B. Kucukemre Aydın, G. Kılıc, A. Suleyman, F. Aydın, D. Yılmazbayhan, N. Guler
Journal: Journal of Allergy and Clinical Immunology (2012)
Myocardial Infarction in Pregnancy
Authors: Edward Phillips
Journal: JAMA (1962)

ABSTRACT To the Editor:— Myocardial infarction in pregnancy is not as rare as the literature would indicate. It is reasonable to suppose that only a minority of such cases are reported in the medical literature. I have seen 3 cases in the last 10 years in the city of Los Angeles. As Dr. Shapiro et al. (JAMA179:966 [March] 1962) indicated, the prognosis seems to be good if the patient survives the first few days of the myocardial infarction.One patient had a myocardial infarction on Jan. 13, 1955, when she was 26 years of age. She was normotensive and without any other concomitant or complicating disease. Her father had died of a myocardial infarction at 51 years of age and her mother was suffering from hypertensive heart disease. After an uneventful recovery from an anterior myocardial infarction, the patient delivered spontaneously a normal child. Seven years later, signs of
Christopher Douglas Rennie
Authors: Steve Payne, Barrie Fischer
Journal: BMJ (2005)

Consultant urologist Bromsgrove (b Port Dixon, Malaya, 1948; q Birmingham 1972; FRCS), died from a heart attack on 14 September 2005.

Chris was brought up in and around Birmingham, returning to Redditch in 1985 as the first full time consultant urologist, after training at St Mary's, Northwick Park, and the Institute of Urology. His commitment to reforming the way in which urology was delivered locally led to the establishment of a five person urology unit in his hospital and a centre to train urologists for the future. Chris was a keen sailor, skier, and golfer, who was learning to become part of a family again. He leaves a son, and a partner, Helen, and her family.
Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536–541
Authors: Anubhav Thukral, Sujoy Ghosh, Satinath Mukhurjee, Subhankar Chowdhury
Journal: Diabetes Care (2012)

We were very enthused to read an interesting article in Diabetes Care (1) that shows that increased insulin resistance in puberty actually starts as many as 3 to 4 years prepubertally, and more than 50% of this variance is unaccounted for by fat percentage, IGF-1, or age of the individual. We would also like to point out a study by Bavdekar et al. (2) that found increased insulin resistance in 8-year-old children from India; most of them were …
Anicteric Carbenicillin Hepatitis
Authors: Francis M. Wilson
Journal: JAMA (1975)

Carbenicillin disodium was temporally associated with eight episodes of a mild reversible anicteric hepatitis characterized by nausea, vomiting, and a tender, somewhat enlarged liver. Serum glutamic and oxaloacetic transaminase as well as alkaline phosphatase levels rose, but serum bilirubin values remained normal. There usually were no signs of concomitant allergy to penicillin, and other penicillins could be given subsequently without ill effects. Biopsy specimens of the liver showed spotty liver cell necrosis with no cholestasis. (<i>JAMA</i>232:818-821, 1975)
Renal vasoconstriction during inhibition of NO synthase: Effects of dietary salt
Authors: Xiaolin Deng, William J. Welch, Christopher S. Wilcox
Journal: Kidney International (1994)

Since dietary salt loading enhances nitric oxide (NO) generation in the kidney, we investigated the hypothesis that changes in salt intake have specific effects on vascular resistance in the kidney mediated by the L-arginine-NO pathway. We contrasted changes in renal and hindquarter vascular resistances (RVR and HQVR) in anesthetized rats during intravenous infusions of graded doses of the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME). Groups (N = 8 to 10) of rats were maintained on a high salt (HS) or low salt (LS) diet for two weeks. Compared to those on LS, rats on HS had a greater increase in mean arterial pressure (delta MAP; +32 +/- 4 vs. +22 +/- 3%; P = 0.05) and RVR (+160 +/- 17 vs. +83 +/- 10%; P < 0.005) and a greater fall in renal blood flow (delta RBF; -47 +/- 3 vs. -32 +/- 4%; P < 0.01); changes in HQVR were similar in the two groups. The enhanced RVR response to L-NAME in HS rats could not be ascribed to the higher renal perfusion pressure (RPP) since it persisted in rats whose RPP was controlled by adjustment of a suprarenal aortic clamp. Changes in RVR with an NO donor (SIN-1) were similar in HS and LS rats. L-NAME reduced plasma renin activity in both HS and LS rats. After inhibition of ACE with captopril, or of angiotensin II type I (AT1) receptor with losartan, the increase in RVR with L-NAME remained greater in HS than LS rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Mel-18 Negatively Regulates <i>INK4a/ARF</i>-Independent Cell Cycle Progression via Akt Inactivation in Breast Cancer
Authors: Jeong-Yeon Lee, Ki-Seok Jang, Dong-Hui Shin, Mi-Yun Oh, Hyun-Jun Kim, Yongseok Kim, Gu Kong
Journal: Cancer Research (2008)

Abstract Mel-18, a polycomb group (PcG) protein, has been suggested as a tumor suppressor in human breast cancer. Previously, we reported that Mel-18 has antiproliferative activity in breast cancer cells. However, its functional mechanism has not been fully elucidated. Here, we investigated the role of Mel-18 in human breast cancer. We saw an inverse correlation between Mel-18 and phospho-Akt, which were expressed at low and high levels, respectively, in primary breast tumor tissues from 40 breast cancer patients. The effect of Mel-18 on cell growth was examined in two breast cancer cell lines, SK-BR-3 and T-47D, which express relatively low and high levels of endogenous Mel-18, respectively. On Mel-18 overexpression in SK-BR-3 cells, cell growth was attenuated and G1 arrest was observed. Likewise, suppression of Mel-18 by antisense expression in T-47D cells led to enhanced cell growth and accelerated G1-S phase transition. In these cells, cyclin-dependent kinase (Cdk)-4 and Cdk2 activities were affected by Mel-18, which were mediated by changes in cyclin D1 expression and p27Kip1 phosphorylation at Thr157, but not by INK4a/ARF genes. The changes were both dependent on the phosphatidylinositol 3-kinase/Akt signaling pathway. Akt phosphorylation at Ser473 was reduced by Mel-18 overexpression in SK-BR-3 cells and enhanced by Mel-18 suppression in T-47D cells. Akt-mediated cytoplasmic localization of p27Kip1 was inhibited by Mel-18 in SK-BR-3 cells. Moreover, Mel-18 overexpression showed reduced glycogen synthase kinase-3β phosphorylation, β-catenin nuclear localization, T-cell factor/lymphoid enhancer factor promoter activity, and cyclin D1 mRNA level. Taken together, we established a linear relationship between Mel-18→Akt→G1 phase regulators. [Cancer Res 2008;68(11):4201–9]
Comment: Conservatism vs Radicalism in Treatment
Authors: Philip Rubin
Journal: JAMA (1968)

The survival results in bladder cancer become poorer as the treatment becomes more radical. In Jewett's report, for stage A lesions, transurethral resection provides a 70% success rate, whereas total cystectomy provides only 50%. For stage Bl, there is little difference in survival with the more aggressive procedures (50% ± 5%). Examination of the radiation results offered by Friedman again illustrates that the more conservative method of treatment (radium as a central source) yields a three-year survival rate, which is distinctly superior to the rate with 2 mev x-ray irradiation therapy, 93% vs 62%, respectively. This observation was also found in the detailed analysis of the experience at the Royal Marsden Hospital in London.<sup>16</sup> Although the figures clearly argue for conservatism in therapy, the truth lies in the unreported facts. The selection of one criterion, depth of penetration, is inadequate to make the patients in any series comparable. In
Follow-up and indications for liver biopsy in HBeAg-negative chronic hepatitis B virus infection with persistently normal ALT: A systematic review
Authors: George V. Papatheodoridis, Spilios Manolakopoulos, Yun-Fan Liaw, Anna Lok
Journal: Journal of Hepatology (2012)

The adequacy of monitoring HBeAg-negative patients based on ALT activity is controversial and current guidelines favor liver biopsy in HBeAg-negative cases with normal ALT and HBV DNA >2000 IU/ml. We systematically reviewed all the available histological data on HBeAg-negative patients with persistently normal ALT (PNALT) to determine the prevalence of significant liver disease and its associating factors.Literature search to identify studies with adult HBeAg-negative patients who had PNALT as defined by the authors, a minimum follow-up of 1 year and histological data. Traditional cut-off values of normal ALT were used in all studies. The definitions of PNALT were considered as acceptable or good if there were ≥3 ALT determinations at unspecified intervals during 6-12 months or predefined intervals during ≥12-month periods, respectively.Six studies including 335 patients met our inclusion criteria. Of these, four studies with 246 patients had good or acceptable definitions of PNALT. In the latter four studies, more than minimal (usually mild) necro-inflammatory activity was observed in 10% and more than mild fibrosis in 8% of all patients (moderate fibrosis: 7%, severe fibrosis: 1%, cirrhosis: 0%), and in 3% and 5% of patients with HBV DNA ≤20,000 IU/ml, respectively.Histologically significant liver disease is rare in HBeAg-negative patients with PNALT based on stringent criteria and serum HBV DNA ≤20,000 IU/ml. Such cases can be considered as true inactive HBV carriers, who require neither liver biopsy nor immediate therapy but continued follow-up.
ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell–derived Flk1+ mesodermal precursor cells
Authors: Hyung Joon Joo, Dong-Kyu Choi, Joon Seo Lim, Jin-Sung Park, Seung-Hun Lee, Sukhyun Song, Jennifer H. Shin, Do-Sun Lim, Injune Kim, Ki-Chul Hwang, Gou Young Koh
Journal: Blood (2012)
Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels
Authors: William W Du, Fengqiong Liu, Sze Wan Shan, Xindi Cindy Ma, Shaan Gupta, Tianru Jin, David Spaner, Sergey N Krylov, Yaou Zhang, Wenhua Ling, Burton B Yang
Journal: Molecular Therapy (2015)

Steatosis is a pivotal event in the initiation and progression of nonalcoholic fatty liver disease (NAFLD) which can be driven by peroxisome proliferator-activated receptor-α (PPAR-α) dysregulation. Through examining the effect of PPAR-α on fatty liver development, we found that PPAR-α is a target of miR-17-5p. Transgenic mice expressing miR-17 developed fatty liver and produced higher levels of triglyceride and cholesterol but lower levels of PPAR-α. Ectopic expression of miR-17 enhanced cellular steatosis. Gain-of-function and loss-of-function experiments confirmed PPAR-α as a target of miR-17-5p. On the other hand, PPAR-α bound to the promoter of miR-17 and promoted its expression. The feed-back loop between miR-17-5p and PPAR-α played a key role in the induction of steatosis and fatty liver development. Mice with high levels of miR-17-5p were sensitive to Dexamethasone-induced fatty liver formation. Inhibition of miR-17-5p suppressed this process and enhanced PPAR-α expression in mice treated with Dexamethasone. Clofibrate, Ciprofibrate, and WY-14643: three agents used for treatment of metabolic disorders, were found to promote PPAR-α expression while decreasing miR-17-5p levels and inhibiting steatosis. Our studies show that miR-17-5p inhibitor and agents used in metabolic disorders may be applied in combination with Dexamethasone in the treatment of anti-inflammation, immunosuppression, and cancer patients. Steatosis is a pivotal event in the initiation and progression of nonalcoholic fatty liver disease (NAFLD) which can be driven by peroxisome proliferator-activated receptor-α (PPAR-α) dysregulation. Through examining the effect of PPAR-α on fatty liver development, we found that PPAR-α is a target of miR-17-5p. Transgenic mice expressing miR-17 developed fatty liver and produced higher levels of triglyceride and cholesterol but lower levels of PPAR-α. Ectopic expression of miR-17 enhanced cellular steatosis. Gain-of-function and loss-of-function experiments confirmed PPAR-α as a target of miR-17-5p. On the other hand, PPAR-α bound to the promoter of miR-17 and promoted its expression. The feed-back loop between miR-17-5p and PPAR-α played a key role in the induction of steatosis and fatty liver development. Mice with high levels of miR-17-5p were sensitive to Dexamethasone-induced fatty liver formation. Inhibition of miR-17-5p suppressed this process and enhanced PPAR-α expression in mice treated with Dexamethasone. Clofibrate, Ciprofibrate, and WY-14643: three agents used for treatment of metabolic disorders, were found to promote PPAR-α expression while decreasing miR-17-5p levels and inhibiting steatosis. Our studies show that miR-17-5p inhibitor and agents used in metabolic disorders may be applied in combination with Dexamethasone in the treatment of anti-inflammation, immunosuppression, and cancer patients.
A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus
Authors: Zhe Jin, Yulan Cheng, Wen Gu, Yingye Zheng, Fumiaki Sato, Yuriko Mori, Alexandru V. Olaru, Bogdan C. Paun, Jian Yang, Takatsugu Kan, Tetsuo Ito, James P. Hamilton, Florin M. Selaru, Rachana Agarwal, Stefan David, John M. Abraham, Herbert C. Wolfsen, Michael B. Wallace, Nicholas J. Shaheen, Kay Washington, Jean Wang, Marcia Irene Canto, Achyut Bhattacharyya, Mark A. Nelson, Paul D. Wagner, Yvonne Romero, Kenneth K. Wang, Ziding Feng, Richard E. Sampliner, Stephen J. Meltzer
Journal: Cancer Research (2009)

Abstract Esophageal adenocarcinoma risk in Barrett's esophagus (BE) is increased 30- to 125-fold versus the general population. Among all BE patients, however, neoplastic progression occurs only once per 200 patient-years. Molecular biomarkers are therefore needed to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression. We therefore performed a retrospective, multicenter, double-blinded validation study of eight BE progression prediction methylation biomarkers. Progression or nonprogression were determined at 2 years (tier 1) and 4 years (tier 2). Methylation was assayed in 145 nonprogressors and 50 progressors using real-time quantitative methylation-specific PCR. Progressors were significantly older than nonprogressors (70.6 versus 62.5 years; P &amp;lt; 0.001). We evaluated a linear combination of the eight markers, using coefficients from a multivariate logistic regression analysis. Areas under the ROC curve (AUC) were high in the 2-year, 4-year, and combined data models (0.843, 0.829, and 0.840; P &amp;lt; 0.001, &amp;lt;0.001, and &amp;lt;0.001, respectively). In addition, even after rigorous overfitting correction, the incremental AUCs contributed by panels based on the 8 markers plus age versus age alone were substantial (Δ-AUC = 0.152, 0.114, and 0.118, respectively) in all 3 models. A methylation biomarker–based panel to predict neoplastic progression in BE has potential clinical value in improving both the efficiency of surveillance endoscopy and the early detection of neoplasia. [Cancer Res 2009;69(10):4112–5]
Residual Venous Thrombosis and Recurrent Thromboembolism
Authors: Vijay Rajput
Journal: Annals of Internal Medicine (2003)

Letters19 August 2003Residual Venous Thrombosis and Recurrent ThromboembolismVijay Rajput, MBBSVijay Rajput, MBBSRobert Wood Johnson Medical School, Camden, NJ 08103 (Rajput)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-4-200308190-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the article by Prandoni and colleagues (1), veins were considered recanalized if they measured 3.0 mm or less in diameter during a 6-year period. However, in a previous study of 1017 patients, it was very unusual to observe a diameter less than 5 mm in cases of DVT (2), and 5 mm was proposed as the minimum threshold value for diagnosis of thrombus (2). Meissner and associates (3) studied patients with unilateral thrombosis and found that segments with residual disease were 0.07 to 0.28 cm smaller than those on the contralateral disease-free side. In addition, the ...References1. Prandoni P, Lensing AW, Prins MH, Bernardi E, Marchiori A, Bagatella P, . Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med. 2002;137:955-60. [PMID: 12484710] LinkGoogle Scholar2. Bosson JL, Riachi M, Pichot O, Michoud E, Carpentier PH, Franco A. Diameters of acute proximal and distal deep venous thrombosis of the lower limbs. Int Angiol. 1998;17:260-7. [PMID: 10204659] MedlineGoogle Scholar3. Meissner MH, Manzo RA, Bergelin RO, Strandness DE. Venous diameter and compliance after deep venous thrombosis. Thromb Haemost. 1994;72:372-6. [PMID: 7855786] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Robert Wood Johnson Medical School, Camden, NJ 08103 (Rajput) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoResidual Venous Thrombosis as a Predictive Factor of Recurrent Venous Thromboembolism Paolo Prandoni , Anthonie W.A. Lensing , Martin H. Prins , Enrico Bernardi , Antonio Marchiori , Paola Bagatella , Michela Frulla , Laura Mosena , Daniela Tormene , Andrea Piccioli , Paolo Simioni , and Antonio Girolami Residual Venous Thrombosis and Recurrent Thromboembolism Paolo Prandoni , Anthonie W.A. Lensing , and Martin H. Prins Residual Venous Thrombosis and Recurrent Thromboembolism James L. Sebastian and Dario M. Torre Residual Venous Thrombosis and Recurrent Thromboembolism Joseph Emmerich and Jean-Nol Fiessinger Metrics 19 August 2003Volume 139, Issue 4Page: 303-304KeywordsThrombosisVeinsVenous thromboembolism ePublished: 19 August 2003 Issue Published: 19 August 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
998 Direct inhibition of intracellular hepatitis C virus replication by ribavirin and its synergistic action used in combination with interferon-alpha
Authors: Y TANABE, N SAKAMOTO, N ENOMOTO, M KUROSAKI, E UEDA, S MAEKAWA, T YAMASHIRO, M NAKAGAWA, C CHEN, N KANAZAWA
Journal: Hepatology (2003)
A Stereoscopic Camera.
Authors: G. H. Stover
Journal: JAMA (1905)

Denver, Colo., Aug. 30, 1905. <h3>To the Editor:</h3> —In making portraits of my patients for the purpose of keeping an accurate record of their condition, I have found it of great advantage to make use of a stereoscopic camera. As ordinarily furnished, these cameras are hardly satisfactory for the purpose, as the portrait is rather small to show details of many lesions. I put on each lens a little portrait attachment sold by photo dealers; this enables me to come close to the subject, giving me a good-sized portrait; but in coming close the images are thrown almost off the plate; this is overcome by putting on the front of the lens carrier a brass sheet, in which a hole has been cut in front of the lenses, and over these holes I placed ten-degree-plane prisms with the bases out, thus bringing the images back on the plate. I make
Variability of transient myocardial ischemia in ambulatory patients with coronary artery disease.
Authors: E G Nabel, J Barry, M B Rocco, S Campbell, K Mead, T Fenton, E J Orav, A P Selwyn
Journal: Circulation (1988)

Ambulatory electrocardiographic (ECG) monitoring of patients with chronic stable angina has demonstrated frequent and prolonged episodes of ischemic ST segment depression, but its clinical use requires an understanding of the components and extent of variability. Therefore, variations in the frequency and duration of episodes of ST segment depression were evaluated with ambulatory ECG recording at daily, weekly, and monthly intervals in 42 patients with chronic stable angina and known coronary artery disease. Data were analyzed with a nested analysis of variance design that yields estimates of variance components. From the estimates of variance components, power calculations and minimum significant percent reductions in frequency and duration of ischemia were derived. During 4,656 hours of ambulatory ECG monitoring, 1,262 episodes of ischemic ST segment depression were detected. The frequency of episodes was 6.3 +/- 0.45/24 hr (mean +/- SEM), and the duration of episodes was 18.3 +/- 2.8/24 hr. Because of variability over time, the ability to detect significant changes was dependent upon the number of subjects, length of monitoring period, and intervals between monitoring periods. In a clinical trial, for example, a sample size of 25 patients monitored for 48 hours with 1 week between control and test conditions would require a 65% reduction in frequency, whereas a sample size of 50 patients monitored under similar conditions would require a 46% reduction in frequency, to attribute the change with 90% power to a therapeutic intervention rather than to a spontaneous variation. When monitoring a single patient for 48 hours with 1 week or 1 month between control and repeat monitoring sessions, episodes of ischemic ST depression must be eliminated to detect significant therapeutic changes in ischemic activity at the 95% confidence level.(ABSTRACT TRUNCATED AT 250 WORDS)
507 SIMULTANEOUS DETECTION OF HEPATITIS C VIRUS ANTIGEN AND ANTIBODIES USING DRIED BLOOD SPOTS SAMPLES
Authors: L.M. Villar, C.P.U. Brandao, B.L.C. Marques, E.F. da Silva, V.A. Marques, C.A. Villela-Nogueira, K.M.R. do Ó, M.T. de Paula, L.L. Lewis-Ximenez, J.A. Sá Ferreira, E. Lampe
Journal: Journal of Hepatology (2013)