Chromosome Patterns in Irradiated and Nonirradiated Patients with Rheumatoid Spondylitis
Authors: DAVID S. NEWCOMBE
Journal: Annals of Internal Medicine (1963)

Article1 December 1963Chromosome Patterns in Irradiated and Nonirradiated Patients with Rheumatoid SpondylitisDAVID S. NEWCOMBE, M.D., ALAN S. COHEN, M.D.DAVID S. NEWCOMBE, M.D.Search for more papers by this author, ALAN S. COHEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-859 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of relatively simple and specific methods for the analysis of human chromosomes, studies of heritable or genetically determined disorders have been extensive. Rheumatoid spondylitis would appear to be an appropriate disorder for such chromosome analyses for several reasons. First, there are indications that genetic mechanisms may play a role in its etiology, that is, the strong tendency toward the familial occurrence of spondylitis, the apparently autosomal dominant type of inheritance with incomplete penetrance, and the appearance of the disorder in twins (1). Second, X-irradiation, now associated with a documented increased incidence of leukemia (2), has been used...References1. HERSHSTECHERSOLOMONWOLPAWHAUSER AHRMWMRH: Heredity in ankylosing spondylitis: a study of fifty families. Amer. J. Hum. Genet. 2: 391, 1950. MedlineGoogle Scholar2. COURT-BROWNDOLL WMR: Leukaemia and aplastic anaemia in patients irradiated for ankylosing spondylitis. Med. Res. Counc. Spec. Rep. London. Series No. 295. 1957. Google Scholar3. CHUGILESPASSANO EHNHK: Types and frequencies of human chromosome aberrations induced by x-rays. Proc. Nat. Acad. Sci. USA. 47: 830, 1961. CrossrefMedlineGoogle Scholar4. BENDERGOOCH MAPC: Persistent chromosome aberrations in irradiated human subjects. Radiat. Res. 16: 44, 1962. CrossrefMedlineGoogle Scholar5. BENDERGOOCH MAPC: Types and rates of x-ray-induced chromosome aberrations in human blood irradiated in vitro. Proc. Nat. Acad. Sci. USA. 48: 522, 1962. CrossrefMedlineGoogle Scholar6. NOWELLHUNGERFORD PCDA: Chromosome studies on normal and leukemic human leukocytes. J. Nat. Cancer Inst. 25: 85, 1960. MedlineGoogle Scholar7. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. J. Nat. Cancer Inst. 27: 1013, 1961. MedlineGoogle Scholar8. GUNZFITZGERALDADAMS FWPHA: An abnormal chromosome in chronic lymphocytic leukaemia. Brit. Med. J. 2: 1097, 1962. CrossrefMedlineGoogle Scholar9. MOORHEADNOWELLMELLMANBATTIPSHUNGERFORD PSPCWJDMDA: Chromosome preparations of leukocytes cultured from peripheral blood. Exp. Cell. Res. 20: 613, 1960. CrossrefMedlineGoogle Scholar10. : A proposed standard system of nomenclature of human mitotic chromosomes. JAMA 174: 159, 1960. MedlineGoogle Scholar11. NEWCOMBECOHEN DSAS: Chromosome patterns and aberrations in rheumatoid spondylitis: Relation to x-irradiation and sex. Arthritis Rheum. 5: 652, 1962 (abstract). Google Scholar12. BUCKTONJACOBSCOURT-BROWNDOLL KEPAWMR: A study of the chromosome damage persisting after therapy for ankylosing spondylitis. Lancet 2: 676, 1962. CrossrefMedlineGoogle Scholar13. JACOBSCOURT-BROWNDOLL PAWMR: Distribution of human chromosome counts in relation to age. Nature 191: 1178, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID S. NEWCOMBE, M.D.; ALAN S. COHEN, M.D.Affiliations: Boston, MassachusettsFrom Robert Dawson Evans Department of Clinical Research, Massachusetts Memorial Hospitals, and the Department of Medicine, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts.This work was supported by grant AM 04599-03 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, and by grants from the New England Chapter of the Arthritis and Rheumatism Foundation and the Medical Foundation, Inc.Presented in abstract before the American Rheumatism Association, December, 1962 (11).Requests for reprints should be addressed to Alan S. Cohen, M.D., Boston University Medical Center, Massachusetts Memorial Hospitals, 65 East Newton Street, Boston 18, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRICERCHE RADIOBIOLOGICHE IN UNA CENTRALE ELETTRONUCLEARE DELL'ENELCancer and arthritisFunctional anatomy of a cytogenetic serviceChromosome Aberrations as a Biological DosimeterMedical genetics 1963 1 December 1963Volume 59, Issue 6Page: 859-864KeywordsAnkylosing spondylitisArthritisChromosomal diseasesChromosomesEtiologyGenetic diseasesHospital medicineMetabolic disordersSpondylitisTwins ePublished: 1 December 2008 Issue Published: 1 December 1963 PDF downloadLoading ...