Prostaglandin A<sub>1</sub>: Antihypertensive and Renal Effects
Authors: JAMES B. LEE
Journal: Annals of Internal Medicine (1971)

Article1 May 1971Prostaglandin A1: Antihypertensive and Renal EffectsStudies in Patients with Essential HypertensionJAMES B. LEE, M.D., JOHN C. MCGIFF, M.D., HARTMUT KANNEGIESSER, M.D., YAVUZ Y. AYKENT, M.D., J. GERARD MUDD, M.D., THOMAS F. FRAWLEY, M.D.JAMES B. LEE, M.D., JOHN C. MCGIFF, M.D., HARTMUT KANNEGIESSER, M.D., YAVUZ Y. AYKENT, M.D., J. GERARD MUDD, M.D., THOMAS F. FRAWLEY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-703 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProstaglandin A1(PGA1) was infused intravenously for 1 hr into six patients with fixed diastolic essential hypertension. Low infusion rates (0.1 to 2.1 µg/kg body weight per min) were not associated with a change in blood pressure but resulted in a significant increase in effective renal plasma flow (ERPF), glomerular filtration rate (GFR), urinary flow, and urinary sodium and potassium excretion. At higher infusion rates (2.1 to 11.2 µg/kg body weight per min) the blood pressure fell from a mean control of 200/112 mm Hg to 140/85 mm Hg. This was associated with a reduction in previously elevated ERPF, GFR, urinary flow, and sodium and potassium excretions to or toward preinfusion levels. Thus, decreased renal perfusion secondary to a reduction in systemic arterial pressure offset the direct renal vasodilating and natriuretic action of PGA1. The net result was that normotension induced by PGA1in hypertensive patients was associated with a normal renal blood flow and a normal sodium excretion....References1. KOLETSKY S and PRITCHARD W: Vasodepressor material in experimental hypertension. 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FRAWLEY, M.D.Affiliations: St. Louis, Missouri▸From the Sections of Experimental Medicine and Cardiology, Department of Internal Medicine, St. Louis University School of Medicine, St. Louis, Mo. 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Antihypertensive AgentsChapter 15. Prostaglandins and Related CompoundsEndocrinological Implications of Prostaglandins 1 May 1971Volume 74, Issue 5Page: 703-710KeywordsBlood pressureBody weightExcretionHeart diseasesMetabolic disordersNatriuretic peptidesPotassiumProstaglandinRenal circulationSodium ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...