tbuckley/cabot-search huggingface dataset:
Experiments With Phenylhydrazine
Authors: Herbert Z. Giffin, Edgar V. Allen
Journal: Annals of Internal Medicine (1928)

Article1 March 1928Experiments With PhenylhydrazineI. Studies On the Blood*HERBERT Z. GIFFIN, M.D., EDGAR V. ALLEN, M.D.HERBERT Z. GIFFIN, M.D., EDGAR V. ALLEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-9-655 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince 1918, when Eppinger and Kloss (1) first introduced phenylhydrazine in the treatment of polycythemia vera, an increasing number of reports from the clinical standpoint have been recorded, notably those of Owen (2) and Brown and Giffin (3). Notwithstanding the excellence of these reports, certain fundamental questions in connection with the effect of the drug remain unanswered. This is due to the difficulty of keeping in touch with patients over long periods and more particularly to the impossibility of subjecting them to the rigid research methods which can be conveniently carried out on animals.The experimental work on animals has... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: †Bibliography for Studies I and II given at the end of Study II.*Abstracted for Proceedings of the Staff Meetings of the Mayo Clinic, 1927, ii, 154-156.The material in this paper was presented in a thesis by Edgar V. Allen to the Facsity of Minnesota in partial fulfillment of ulty of the Graduate School of the Univerthe requirements for the degree of M.S. in Medicine, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCombined repeated dose and reproductive/developmental toxicity screening test of tert-butylhydrazine monohydrochloride in ratsPhenylhydrazine haematotoxicityPhenylhydrazine-induced anemia in chinook salmonThe effect of acetylphenylhydrazine upon epithelial turnover in the small intestineAregenerative Anemia Associated with Benign ThymomaDas ReticulocytenvolumenThe permeability and the lipid content of immature red cellsDie Entgiftung des PhenylhydrazinsÜber den Verlauf der akuten, experimentellen Blutgiftanämie im Höhenklima und im Tieflande unter Darreichung von kolloidalem EisenoxydVersuch einer Behandlung des Morbus maculosus Werlhofii mit Phenylhydracinum hydrochloricumDie erythrolytische Komponente des Phenylhydrazin-Hydrochlorids 1 March 1928Volume 1, Issue 9Page: 655-676KeywordsDrugsGraduate medical educationPolycythemia veraTouch Issue Published: 1 March 1928 PDF DownloadLoading ...
1024-48 Intraprocedural stent thrombosis: A potentially new emerging complication with usage of long stents in the drug-eluting stent era
Authors: Alaide Chieffo, Erminio Bonizzoni, Dejan Orlic, Renata Rogacka, Flavio Airoldi, Matteo Montorfano, Nicola Corvaja, Ghada W Michail, Antonio Colombo
Journal: Journal of the American College of Cardiology (2004)
Letter: Anticoagulants in infective endocarditis.
Authors: J A Kanis
Journal: BMJ (1973)

We consider that a self-administered questionnaire can be used to detect depression, although a single direct question such as we asked would not be very sensi- tive.However, it is noteworthy that 29 °/, of the replies to the question were positive.There was no excess of positive replies in patients taking methyldopa compared with patients taking other drugs.Patients who became severely depressed on any treatment regimen would have their treatment altered.These patients, however, represent only a stnall proportion of the patients studied.Drs. R. P. Snaith and M. McCoubrie (personal communication) have given the Wakefield Self-Assessment Depression In- ventory to 134 patients receiving me-thyldopa, and have also failed to demonstrate an increase in depression while taking this drug.-Weare, etc.,
Transplacental haemorrhage in Rh-haemolytic disease.
Authors: B. G. Grobbelaar
Journal: BMJ (1968)

DWIALJOUWALthese thousands of problems together rather than separately.These days there is a bitter competition among psychiatrists to discharge more and more long-stay patients, but very little thought has been given to the other side of the story: the community tolerance, its costs, and its limitations.Physical discharge of a patient is no substitute for cure.The criterion is that he should be happier and more useful in the community than in the hospital.I believe there is a case for moder- ating our enthusiasm to empty the mental hospitals with some research on discharged 'patients by individuals working exclusively in the community.-Iam, etc.,
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
Authors: Susanne Schnittger, Claudia Schoch, Wolfgang Kern, Cristina Mecucci, Claudia Tschulik, Massimo F. Martelli, Torsten Haferlach, Wolfgang Hiddemann, Brunangelo Falini
Journal: Blood (2005)
Effects on Pulmonary Function of Once-Daily (qd) Budesonide and Formoterol Administered via One Pressurized Metered-Dose Inhaler (pMDI) in Adults and Adolescents With Asthma Previously Stable With Twice-Daily (bid) Budesonide/Formoterol pMDI
Authors: E KERWIN, J OPPENHEIMER, C LAFORCE, C MILLER, L ODOWD, M GOLDMAN
Journal: Journal of Allergy and Clinical Immunology (2008)
A hepatitis like picture in typhoid fever.
Authors: P Pais
Journal: BMJ (1984)

5 observations de fievre typhoide avec ictere, presentant un tableau clinique semblable a celui de l'hepatite virale A. Hemoculture positive pour Salmonella typhi, resultats negatifs des tests de virus d'hepatite. Efficacite des traitements appropries: co-trimoxazole et chloramphenicol dans 4 cas, gentamycine et ampicilline dans le 5eme
Effect of the Sphere Standards on the incidence of communicable and infectious diseases in a returnee camp in South Sudan
Authors: Masashi Rotte, Harsh Sule, Bon Ku
Journal: The Lancet Global Health (2014)

BackgroundThe Sphere Standards are primarily focused on factors that acutely affect survival instead of guiding long-term development in displaced populations and have gained consensus in more than 200 aid organisations. However, research was not available to back up every Standard and in those cases the Standards were based on expert or consensus opinion. Therefore, research to validate or refine the Standards will be of benefit to the humanitarian community and the people they serve.MethodsA retrospective study was done at a UN High Commissioner for Refugees camp for returnees from Sudan to South Sudan before and after an intervention to introduce the Sphere Standards for water, sanitation, and hygiene (WASH). Data were collected from May 17, 2012, to July 31, 2012. The daily proportion of the camp diagnosed with a communicable or infectious disease was calculated by comparing the daily camp population to the daily counts from the camp's medical clinic. A χ2 analysis was done to compare the weekly disease proportions before and after the camp met the Sphere Standards for WASH.FindingsThe camp clinic recorded 12 655 consultations. The weekly prevalences of the camp population diagnosed with diarrhoea, an upper respiratory tract infection, or a lower respiratory tract infection in the week before the camp met the Sphere Standards were 0·67%, 0·59%, and 0·34%, respectively. 2 weeks afterwards, they were 0·99%, 1·68%, and 0·57%, respectively. In the fourth week the prevalences for all three decreased (0·82%, 1·48%, and 0·39%, respectively). This pattern was statistically significant for all age groups and also for subgroup analysis on returnees younger than 5 years. Percentages for the diseases tracked ranged from 0·14% to 1·68% with p<0·05.InterpretationFactors such as the massive influx of returnees to the camp and the introduction of local pathogens into the returnee camp population probably muted the initial effects of improved WASH on the camp. These results suggest that achievement and maintainence of the Sphere Standards will have a significant, although possibly delayed, effect on the incidence of communicable and infectious diseases during a complex humanitarian emergency.FundingNone.
How I'd like to be treated if I was terminally ill
Authors: K. E Groves
Journal: BMJ (1995)

I'd like to know that my lump or bump would be removed quickly, in its entirety, before I've had time to fiddle with it so much that I blame myself for it metastasising or before a fine needle aspiration has aspirated all the normal cells, left the “baddies” laughing, and lulled me into a false sense of security.

I would wish to be told the outcome and prognosis by a doctor who will neither have me dead and buried before the diagnostic ink has dried on the paper, nor give me false reassurance and try to treat my untreatable illness until I haven't the strength to endure the attempt. Then I would like to hear that prognosis in terms of months rather than years, weeks rather than months, or even days rather than weeks, instead of as an absolute six weeks or six months (even as an approximation) so that I don't start ticking the days off on the calendar and then jump up and down for joy when I realise I've passed my “sell by date” and that therefore they must have been wrong and really I'm ok.

I would want to be able to choose a consultant who would sit on my bed, without his (or her) entourage, unafraid of what I might ask him and be prepared to explain to me, repeatedly, in words of one syllable, what I cannot grasp—and then do it all over again in one week or two weeks or one month later with a gentle consistency and sensitive honesty that leaves me in no doubt as to the truth of the …
Toxic Tricyclic Antidepressant Levels and the ECG
Authors: David A. Johnson
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The cardiovascular dynamics of tricyclic antidepressant (TCA) overdoses have been the subject of several recent reports.<sup>1-5</sup>Several clinical variables, in particular the ECG, have been proposed as guides to the severity of the poisoning. Tachycardia and QRS prolongation are particularly important signs.<sup>3</sup>In the absence of plasma level determinations, QRS prolongation is the most reliable indicator of a serious overdose.<sup>4</sup>There is one previous report of an amitriptyline hydrochloride overdose with toxic plasma levels in which the QRS intervals were normal and the only ECG abnormality was a sinus tachycarida.<sup>5</sup>We report a case of a TCA overdose involving doxepin hydrochloride (Sinequan) with an entirely normal ECG. <h3>Report of a Case.—</h3> A 49-year-old woman with a long history of psychiatric disorders was brought to the emergency room of Naval Regional Medical Center, Portsmouth, Va, after her husband found her in a somnolent state.
NITROUS OXID AND OXYGEN ANESTHESIA
Authors: WILLIAM D. HAGGARD
Journal: JAMA (1910)

Dr. Morse spoke of the value of getting a record from the mother of the exact dietary of the child.I never treat a child without doing this, and I think it is exceedingly im¬ portant.I secure not only a list of the various foods ad¬ ministered, but also a statement of the amounts of each food.The examination of the stools, as has been suggested by Dr. Talbot, is not a difficult procedure, and one can gather much valuable information from the macroscopic .studyal.The microscopic examination is important, but not so much so as the macroscopic.The sooner we realize that the examination of the stools is an easy procedure, the sooner Wo shall employ it as a routine measure.
Transpapillary Placement of an Endoprosthesis with the Aid of the Frimberger Varioguide
Authors: Jutta Gospos, W. Kühner, J. Weingart, A. Sommer, R. Ottenjann
Journal: Endoscopy (1988)

The guide wire, an important requisite for the placement of endoscopic transpapillary biliary prostheses, should combine two, normally incompatible, properties: a high degree of flexibility for atraumatic passage through irregular or "bent" stenoses, and a high degree of stiffness, to prevent sidewise deviation during advancement of the prosthesis. These opposing, formerly incompatible, properties are combined in a new type of guide wire, known as the Varioguide. With the aid of a tension controller, the stiffness of the Varioguide can be varied steplessly. In 88.2% of 68 patients with stenosis of the bile duct we succeeded in placing a transpapillary endoprosthesis with the Varioguide. In 13 cases in which a previous attempt with the conventional guide wire was unsuccessful, placement of the endoprosthesis was successfully accomplished with the Varioguide; the reverse was true in only a single patient. In the case of very narrow, rigid high stenoses, in which placement of a transpapillary endoprosthesis is especially difficult, the Varioguide has proved highly suitable (stenoses of the bile duct bifurcation).
Perforation of Duodenal Ulcer into Common Hepatic Duct
Authors: B. Ruebner
Journal: BMJ (1954)

Thompson et,al. (1952), in reporting a case of Ki. pneu- moniae meningitis with bacteriaemia and-pneumonia, made a careful review of the literature and analysed 118 cases, 31 with recovery.According to their Table 3, in the pre- sulphonamide era, of 60 cases only 4 recovered, but with sulphonamides alone, of 20 cases 9 recovered.With a combination of sulphonamides and penicillin, of 15 cases 9 recovered; and with sulphonamides, penicillin, and streptomycin, of 13 cases 7 recovered.It is noteworthy that with penicillin and streptomycin, alone or in combination, none recovered.On the other hand, one case (Martin and Sureau, cited by Bombardier, 1950) recovered with chloramphenicol treatment after failure of sulphonamides, penicillin, and streptomycin.On theoretical grounds it would appear that the drug of choice in the treatment of Bacterium friedldnderi meningitis is chloramphenicol, because of the ready attainment of therapeutic levels in the cerebrospinal fluid (Ross et al., 1949; Hewitt and Williams, 1950).There is some evidence that oxytetracycline (" terramycin ") also crosses the blood- brain barrier (Werner et al., 1950), but aureomycin is known to be a poor drug for systemic administration in meningitic disease.The case here reported did extremely well on sulpha- dimidine alone, and this shows -that clinical judgment must remain, in the last.analysis, the supreme arbiter, even in questions of treatment.Except when confronted with fulminating disease, I would renew a plea, made by Banks and others, for withholding intrathecal treatment with antibiotics in purulent meningitis until the bacteriological diagnosis and the clinical course of the disease show it to be imperative.Sulphonamides by the oral or parenteral route, when they do not effect a cure, always give time for deliberation and for completely informed final treatment.My thanks are due to Dr.
Mirror writing: Adults making A-non-B errors?
Authors: Mark L. Latash
Journal: Behavioral and Brain Sciences (2001)

Errors and episodes of “freezing” seen during mirror writing by adults can be incorporated into the model suggested in Thelen et al.'s target article This requires assigning an important role to internal inverse models stored in memory. The strongly anti-dualism position of Thelen et al.'s leaves little room for the Bernsteinian notion of activity.
Welsh Assembly appoints health secretary
Authors: R. Dobson
Journal: BMJ (1999)

Israel issues new rules on detainees:The facility to use chains and handcuffs to restrain security prisoners and detaineesmostly Palestinians but also Israelis-in hospital beds has been much reduced by new regulations issued by Israel's justice ministry.Under the new rules, physical restraints may be used only when other reasonable methods cannot prevent a risk of escape.The patient must be untied if chaining interferes with medical treatment
PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth
Authors: Gary A. Wayman, Diptiman D. Bose, Dongren Yang, Adam Lesiak, Donald Bruun, Soren Impey, Veronica Ledoux, Isaac N. Pessah, Pamela J. Lein
Journal: Environmental Health Perspectives (2012)

Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) promote dendritic growth in hippocampal neurons via ryanodine receptor (RyR)-dependent mechanisms; however, downstream signaling events that link enhanced RyR activity to dendritic growth are unknown. Activity-dependent dendritic growth, which is a critical determinant of neuronal connectivity in the developing brain, is mediated by calcium ion (Ca(2+))-dependent activation of Ca(2+)/calmodulin kinase-I (CaMKI), which triggers cAMP response element binding protein (CREB)-dependent Wnt2 transcription. RyRs regulate the spatiotemporal dynamics of intracellular Ca(2+) signals, but whether RyRs promote dendritic growth via modulation of this signaling pathway is not known.We tested the hypothesis that the CaMKI-CREB-Wnt2 signaling pathway couples NDL PCB-enhanced RyR activity to dendritic arborization.Ca(2+) imaging of dissociated cultures of primary rat hippocampal neurons indicated that PCB-95 (2,2',3,5'6-pentachlorobiphenyl; a potent RyR potentiator), enhanced synchronized Ca(2+) oscillations in somata and dendrites that were blocked by ryanodine. As determined by Western blotting and quantitative polymerase chain reaction, PCB-95 also activated CREB and up-regulated Wnt2. Blocking CaMKK, CaMKIα/γ, MEK/ERK, CREB, or Wnt2 prevented PCB-95-induced dendritic growth. Antagonism of γ-aminobutyric acid (GABA) receptors with bicuculline (BIC) phenocopied the dendrite-promoting effects of PCB-95, and pharmacological antagonism or siRNA knockdown of RyR blocked BIC-induced dendritic growth in dissociated and slice cultures of hippocampal neurons.RyR activity contributes to dynamic remodeling of dendritic architecture in response to NDL PCBs via CaMKI-CREB-Wnt2 signaling in rats. Our findings identify PCBs as candidate environmental risk factors for neurodevelopmental disorders, especially in children with heritable deficits in calcium signaling associated with autism.
Health Insurance Reform and the Physician-Patient Relationship-Reply
Authors: Wendy E. Parmet
Journal: JAMA (1993)

In Reply.  —Both Dr Casey and Mr Kupor make the valuable point that reform of the health care financing system alone will not resolve the problems associated with malpractice litigation. Nor will it ensure quality care. Nevertheless, there is still reason to believe that guaranteeing universal access to care, especially through a centralized system, will help.  While Kupor is correct in stating that some studies suggest that the abolition of the collateral source rule has led to only modest reductions in damages in those states in which it has been tried, such experiences may not predict accurately the effects of universal access. Under current conditions, abolition of the collateral source rule has no effect whatsoever in the case of uninsured patients. Nor can would-be litigants and jurors be assured that all future medical expenses associated with an injury will be covered by existing medical insurance. With universal coverage, these problems
Pathologic Features of Atrioventricular and Intraventricular Conduction Disturbances in Acute Myocardial Infarction
Authors: D. B. HACKEL, E. H. ESTES
Journal: Circulation (1971)

of continuous elec- trocardiographic monitoring techniques has resulted in recognition that conduction disturbances occur more frequently in patients with acute myocardial infarction than was previously thought to be the case.Complete atrioventricular (A-V) block has been report- ed in up to 9% of patients who have had acute infarcts,1 and bundle-branch block has been recorded in 13% of cases.2Complete A-V block is an especially important complication of acute infarction since it is associated with a higher mortality rate.For example, in a recent report by Kostuk and Beanlands, the mortality in 378 patients with acute myocardial infarc- tion was 20%, whereas in those patients who also developed complete A-V block the mortality was 50%.1 Important differences have been described between A-V block occurring during the course of acute posterior as contrasted with acute anterior infarction (table 1).A-V block occurs more frequently in patients with acute posterior wall infarction, but it is associated with a lower mortality rate than A-V block with acute anterior infarction.For example, Norris reported that out of 34 cases of second and third degree A-V block occurring in 276 patients with acute infarctions, 26 had a posterior and eight an anterior infarct.3
The price of poor pandemic communication
Authors: T. Abraham
Journal: BMJ (2010)

<h3>ABSTRACT</h3> The striatum is thought to play a central role in action selection and reinforcement, and optogenetic experiments suggest differential roles for direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs). However, the encoding of value-related information in dMSNs and iMSNs during adaptive decision-making is not well understood. We trained mice on a dynamic foraging task where they had to learn the value of different options based on their recent history of choices and outcomes. Single-cell calcium imaging in dorsomedial striatum revealed that dMSNs and iMSNs were oppositely modulated by the updated value of the different options. Additionally, we found that iMSNs were more active as animals slowed between trials, likely reflecting ongoing changes in motivational state. Together, our results demonstrate that co-activation of dMSNs and iMSNs during action initiation does not simply encode action identity, but instead reflects pathway-specific encoding of movement, motivation, and value information necessary for adaptive decision-making.
Cyclin B1 and Other Cyclins as Tumor Antigens in Immunosurveillance and Immunotherapy of Cancer
Authors: Ann Marie Egloff, Laura A. Vella, Olivera J. Finn
Journal: Cancer Research (2006)

Abstract Uncontrolled cell division is an indispensable event in tumor progression, and numerous molecules involved in this process have been the focus of intense investigation in tumor biology. Cyclins, molecules that orchestrate normal cell cycle progression, are abnormally overexpressed in various human cancers. We review evidence that the immune system recognizes some abnormally expressed cyclins as tumor antigens, such as cyclin B1, and we analyze the potential of cyclins D, E, and A to serve a similar function in cancer immunosurveillance. (Cancer Res 2006; 66(1): 6-9)
Uncommon Causes of Stroke
Authors: Mario Di Napoli
Journal: JAMA (2009)

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