tbuckley/cabot-search huggingface dataset:
Abstract P5-13-06: Seasonal variation in onset of inflammatory breast cancer: Evidence of an infectious trigger
Authors: S Hashmi, Y Liu, J Bethony, M Cristofanilli, PH Levine
Journal: Cancer Research (2013)

Abstract Introduction: Inflammatory breast cancer (IBC) is a rare but extraordinarily aggressive disease with a number of studies indicating that environmental factors play the most important role. We have identified four reported clusters of IBC and our investigations thus far suggest that local toxic or infectious agents could be involved in the pathogenesis of the disease. IBC, like Burkitt's lymphoma (BL) has been reported to cluster and both have been implicated with infectious agents. Since BL has been reported to have a seasonal variation attributed to acute malaria symptoms as the precipitating agent, we decided to investigate the seasonality of IBC in two populations. Methods: For our analysis we used the datasets of two IBC referral groups. The first group consisted of a series of 163 consecutive cases of patients seen at Fox Chase Cancer Center (FCCC) almost all being from the Northeast U.S. (NE) and Canada. At the time of initial visit a detailed series of questions was specifically directed at identifying the accurate time of the first onset of symptoms/signs including skin rash, swelling, pain, nipple retraction and palpable mass. The second was the IBC registry (IBCR), established at the George Washington University with the purpose of collecting standardized clinical and epidemiologic data (including a detailed interview) and biospecimens from patients with IBC in the U.S and Canada. Complete data on patients in both groups were evaluated, including diagnostic workup, pathologic findings and treatment. Results: Of the 163 FCCC patients, 156 had the month of onset of symptoms clearly delineated. Of the 161 patients in the IBCR, 153 had month of symptomatic onset defined. In the combined groups, 181 NE patients were compared with 63 from the South. A seasonal pattern was noted in the NE patients, a bimodal pattern showing most patients with onset in March and July-Sept. No seasonal pattern was noted in patients from the South. Conclusion: The reports of IBC clusters are consistent with an acute triggering factor, possibly an infection. The seasonality we observed in NE patients but not in southern patients is consistent with this hypothesis. We are currently continuing to investigate clusters of IBC and are testing for specific candidate infectious agents as well as candidate environmental toxic agents to further understand possible triggers for this disease. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-13-06.
Issues in the management of prisoners infected with HIV-1: the King's College Hospital HIV prison service retrospective cohort study
Authors: S. Edwards
Journal: BMJ (2001)

Concern has been raised about the quality of health care provided to prisoners in England and Wales. 1 2 The management of prisoners infected with HIV-1 is challenging: a high proportion are injecting drug users, there are issues regarding confidentiality, and administering complex antiretroviral regimens may be difficult in prison. We reviewed our experience of providing specialist HIV care to prisoners between October 1994 and July 1999.

In October 1994, King's College Hospital was contracted to provide care to male prisoners with HIV-1 and sexually transmitted diseases at Wandsworth and Brixton prisons in south London. Prisoners access the service through self referral or referral by wing officers and prison healthcare workers.

Between October 1994 and July 1999 six prisoners were newly diagnosed as positive for antibodies to HIV-1 and 121 said that they had previously tested positive for antibodies to HIV-1. Of those 121, 75 were confirmed as positive for antibodies to HIV-1 and 25 tested negative for antibodies to HIV-1. Fourteen …
Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue
Authors: S. M Sacre, S. K Drexler, E. Andreakos, M. Feldmann, F. M Brennan, B. M J Foxwell
Journal: Annals of the Rheumatic Diseases (2007)

In the last decade the development of a number of biological therapies has revolutionised the treatment of rheumatic diseases. The first and most widely used of these approaches, tumour necrosis factor (TNF) blockade (infliximab, entanercept, adalimumab), has now been administered to over a million patients. However, the success of these biological therapies has also highlighted their limitations. None of these treatments has shown a 100% patient response; normally responses are in the 50–70% range. As proteins, these drugs cannot be given orally and they are expensive to produce, a cost ultimately borne by the patient/health provider that can seriously limit the availability of these drugs. Lastly, these treatments, whether involving the systemic neutralisation of a cytokine (eg, TNF or IL6 receptor blockade (tocilizumab)), the ablation of a B cell population (anti-CD20, rituximab), or the potential disruption of important cellular interactions as with CTLA4-Ig (abatacept), can cause major perturbations of the immune system, the long-term effects of which are still unclear. At present, treatments such as TNF blockade can result in an increased infectious risk and the reactivation of tuberculosis can be a major issue in certain populations. As with all therapies, there is an increasing large refractory population over time. Therefore, despite the undoubted success of these therapies, there is room for improvement. Although it might be too much to expect any new treatment to affect a "cure" (all the current biological therapies require repeated administrations), there are definite gains to be made in terms of cost, oral bioavailability and a more selective interference with the immune–inflammatory response.
Haemodynamic changes during tilt after autonomic blockade in spontaneously hypertensive rats
Authors: E. NORESSON, J. V. JONES, M. HALLBACK
Journal: Cardiovascular Research (1977)

The haemodynamic shifts during head up and head down tilt were investigated in adult spontaneously hypertensive rats (SHR) and matched normotensive control rats (NCR) under nembutal anaesthesia and autonomic blockage. During head up tilt a greater fall in blood pressure and stroke volume was observed in SHR than in NCR, while the reverse was true when tilted in the opposite direction. This altered cardiac response to venous filling, also observed in patients with essential hypertension, is suggested to be caused by an altered Frank-Starling relationship of the hypertrophied heart in hypertensive individuals.
Natural regulatory T cells control the development of atherosclerosis in mice
Authors: Hafid Ait-Oufella, Benoît L Salomon, Stéphane Potteaux, Anna-Karin L Robertson, Pierre Gourdy, Joffrey Zoll, Régine Merval, Bruno Esposito, José L Cohen, Sylvain Fisson, Richard A Flavell, Göran K Hansson, David Klatzmann, Alain Tedgui, Ziad Mallat
Journal: Nature Medicine (2006)
Evaluation of cutaneous photodamage using a photographic scale
Authors: C. LARNIER, J.-P. ORTONNE, A. VENOT, B. FAIVRE, J.-C. BEANI, P. THOMAS, T.C. BROWN, E. SENDAGORTA
Journal: British Journal of Dermatology (1994)

Clinical assessments of photodamage are based upon a subjective evaluation of characteristic features such as wrinkling and pigmentary change, and are influenced by inter-observer differences in grading criteria. In an effort to standardize the grading of photodamage severity, we have developed a six-point photographic scale in which each of the six grades of overall photodamage severity is depicted by three photographs. The use of three photographs to portray each grade illustrates the diversity and range of manifestations within each grade. This photographic scale was tested by two groups of dermatologists, who used it on two occasions to grade the overall photodamage severity of a single group of female Caucasian subjects. Results indicate high inter-observer agreement, with chance-corrected agreement ranging from 0.44 to 0.63 and from 0.54 to 0.76 on the first and second occasions, respectively. Intra-observer repeatability was high, with chance-corrected agreement ranging from 0.56 to 0.78. Inter- and intra-observer differences were within one category in nearly all cases. Similar grades were assigned by dermatologists with and without experience in treating photodamaged patients. We conclude that application of this scale results in consistent and reproducible clinical evaluations of overall photodamage severity in Caucasian subjects. The scale may be useful in categorizing subjects for epidemiological studies, or in selecting patients for clinical trials.
Cytomegalovirus-associated Gastric Ulcer
Authors: Wendy J. Munckhof, Michael J. Richards
Journal: Annals of Internal Medicine (1992)

Letters15 November 1992Cytomegalovirus-associated Gastric UlcerWendy J. Munckhof, MBBS, Michael J. Richards, MBBSWendy J. Munckhof, MBBSSearch for more papers by this author, Michael J. Richards, MBBSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-10-877_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Gastric ulceration in association with cytomegalovirus (CMV) most commonly occurs in immunocompromised patients (1, 2). We report a case of CMV-associated gastric ulceration in an immunosuppressed patient in whom healing of ulceration and rapid resolution of fever and constitutional symptoms occurred twice after treatment with ganciclovir.A 74-year-old woman presented with a 3-week history of fever, weight loss, and epigastric pain after meals. She had a history of autoimmune haemolytic anaemia (treated with azathioprine, 100 mg daily, and danazol), pernicious anaemia, renal impairment, and IgA deficiency. Gastroscopy showed shallow ulcers in the stomach, and histologic examination showed...References1. ShusterCoxBhatiaMiner LGPP. Gastric mucosal nodules due to cytomegalovirus infection. Dig Dis Sci. 1989;34:103-7. CrossrefMedlineGoogle Scholar2. BuhlesMastreTinker WBA. Ganciclovir treatment of life- or sight-threatening cytomegalovirus infection: experience in 314 immunocompromised patients. Rev Infect Dis. 1988;10(Suppl 3):S495-506. CrossrefMedlineGoogle Scholar3. Balfour H. Management of cytomegalovirus disease with antiviral drugs. Rev Infect Dis. 1990;12(Suppl 7):S849-60. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Austin Hospital Heidelberg, Victoria, Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCYTOMEGALOVIRUS‐ASSOCIATED GASTRIC ULCERS IN IMMUNOCOMPROMISED PATIENTSDisseminated Cytomegalovirus Infection in an Immunocompetent Adult Successfully Treated with Ganciclovir 15 November 1992Volume 117, Issue 10Page: 877-877KeywordsCytomegalovirus infectionFeversGastric ulcersGastroenterology and hepatologyStomachUlcersWeight loss Issue Published: 15 November 1992 PDF DownloadLoading ...
Stress fracture of a rib.
Authors: J Pereira
Journal: British Journal of Sports Medicine (1985)

26like muscle stiffness, corns and callosities.Female middle distance runners had no injuries in the muscles but ligamentous injuries of the knee and ankle with tendon involvement of both tibialis anterior and Achilles tendons.Female long distance runners were the second largest group in their sex with more ligamentous injuries of the foot and ankle and miscellaneous injuries like shin-splints, metatarsalgia and muscle stiffness.No injury of tendon, bursae, cartilage and bone was seen.Male counterparts had the predominance of cartilage injuries, chondromalacia patellae, early osteoarthritic changes and cystic meniscus and knee injuries of the collateral ligaments and patellofemoral pain.
Adenoviral mediated overexpression of human β2 adrenergic receptor after direct delivery into canine myocardium
Authors: Scott C. Silvestry, Karsten Peppel, R.Eric Lilly, Greg Heintz, Walther J. Koch, Carmelo Milano, Donald D. Glower, Robert J. Lefkowitz
Journal: Journal of the American College of Cardiology (1996)
Smoking and Type 2 Diabetes
Authors: Eric L. Ding, Frank B. Hu
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone Marrow Granulomatous Inflammation
Authors: Yiyan Liu
Journal: Clinical Nuclear Medicine (2008)

Fluorodeoxyglucose (FDG) is not specific for malignancies and various forms of inflammatory lesions may demonstrate increased uptake. We report a case of a 46-year-old woman who presented with chronic leg pain, and MRI showed abnormal signal of the leg. FDG PET-CT demonstrated multiple foci of intense uptake of the bone marrow of the lower extremities suspicious for hematopoietic malignancy. Biopsy revealed necrotizing granulomatous inflammation. Even though granulomatous inflammation is uncommon in the bone marrow, it should be included in the differential diagnoses in cases with abnormal focal FDG uptake on PET images.
Antidepressants in Pregnancy Don’t Lead to Cardiac Defects in Infants
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPARISON OF EVEROLIMUS-ELUTING AND SIROLIMUS-ELUTING STENTS FOR CORONARY REVASCULARIZATION: THE IRIS-DES REGISTRY
Authors: Seung-Jung Park, Duk-Woo Park, Gyung-Min Park, Ki Won Hwang, Yong Giun Kim, Jung-Min Ahn, Hae Geun Song, Won-Jang Kim, Jong-Young Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee
Journal: Journal of the American College of Cardiology (2011)
DECAY OF DECIDUOUS TEETH
Authors: Oliver T. Osborne
Journal: JAMA (1927)

<h3>To the Editor:</h3> —In Queries and Minor Notes (The Journal, March 26, p. 1024) is an answer to a correspondent from Minnesota who asks how he can prevent decay of deciduous teeth. Scrubbing the teeth will not do a particle of good. These children are apparently short on lime; the mother's milk was insufficient. The correspondent should have been advised to give the child proper food, including plenty of vitamins and plenty of milk, as well as feeding extra calcium. These children are often short on thyroid, and poor thyroid makes for teeth that decay rapidly in young children. Parathyroid extract may be of some value, and so is thymus at times. Apparently, the mother's milk of these children does not contain the proper elements of nutrition. I would recommend a careful study of the article on this subject by dentist Weston A. Price of Cleveland (<i>Am. J. Dis. Child.</i>
???Halo??? Sign on Indium-111 Leukocyte Scan in Gangrenous Cholecystitis
Authors: JOHN M. BAUMAN, MAYOLA BOYKIN, MICHAEL F. HARTSHORNE, MICHAEL A. CAWTHON, ALFRED J. LANDRY
Journal: Clinical Nuclear Medicine (1986)

A 56-year-old man with a long history of Crohn's disease was evaluated by In-111 labeled leukocyte scanning. A “halo” of leukocyte activity was seen around the gallbladder fossa. A gangrenous gallbladder was removed at surgery.
A Measles Epidemic Threshold in a Highly Vaccinated Population
Authors: Jacco Wallinga, Janneke C. M Heijne, Mirjam Kretzschmar
Journal: PLoS Medicine (2005)

Mass vaccination against measles has successfully lowered the incidence of the disease and has changed the epidemic pattern from a roughly biennial cycle to an irregular sequence of outbreaks. A possible explanation for this sequence of outbreaks is that the vaccinated population is protected by solid herd immunity. If so, we would expect to see the fraction of susceptible individuals remaining below an epidemic threshold. An alternative explanation is the occurrence of occasional localised lapses in herd immunity that allow for major outbreaks in areas with a low vaccine coverage. In that case, we would expect the fraction of susceptible individuals to exceed an epidemic threshold before outbreaks occur. These two explanations for the irregular sequence of measles outbreaks can be tested against observations of both the fraction of susceptible individuals and infection attack rates.We have estimated both the fraction of susceptible individuals at the start of each epidemic year and the infection attack rates for each epidemic year in the Netherlands over a 28-y period. During this period the vaccine coverage averaged 93%, and there was no sustained measles transmission. Several measles outbreaks occurred in communities with low vaccine coverage, and these ended without intervention. We show that there is a clear threshold value for the fraction of susceptible individuals, below which only minor outbreaks occurred, and above which both minor and major outbreaks occurred. A precise, quantitative relationship exists between the fraction of susceptible individuals in excess of this threshold and the infection attack rate during the major outbreaks.In populations with a high but heterogeneous vaccine coverage, measles transmission can be interrupted without establishing solid herd immunity. When infection is reintroduced, a major outbreak can occur in the communities with low vaccine coverage. During such a major outbreak, each additional susceptible individual in excess of the threshold is associated with almost two additional infections. This quantitative relationship offers potential for anticipating both the likelihood and size of future major outbreaks when measles transmission has been interrupted.
Ronald Crum MacLeod
Authors: D. MacLeod
Journal: BMJ (2003)

Former medical officer of health Devon (b 1912; q Glasgow 1937; DPH, DTM&H, MD, MFCM), d July 2002.

After qualifying, he joined the army and spent most of the second world war in Persia, reaching the rank of lieutenant colonel. After the war he became medical officer for the East Africa Groundnut Scheme. He then lived briefly in Liverpool before joining the department of infectious diseases at the University of Glasgow. In 1955 he became medical officer of health for east Devon. He had a lifelong interest in history and in Scotland. He leaves a wife, Heather; two children; and five grandchildren.
AGAIN, THE OPERATION FOR HALLUX VALGUS
Authors: ALBERT H. FREIBERG
Journal: JAMA (1924)

It is not to be gainsaid that the ideal operation for hallux valgus would be one that would leave the foot as nearly like a normal foot as possible; this refers at once to the external conformation, intrinsic structure; mobility up to the normal limits, and function which would combine efficiency and complete comfort. If there is occasion to add anything to a literature of respectable proportions, it must lie in the fact that there is reason for dissatisfaction with what has been heretofore proposed or practiced. I know of no procedure which, at least from a theoretical point of view, approaches the ideal to the extent that is reached by the plastic operation of Silver.1He holds the chief abnormality to lie in the alterations of the capsule of the joint, together with a degree of hypertrophy of bone on the mesial side of the metatarsal head which
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
Authors: Alex J. Tipping, Cristina Pina, Anders Castor, Dengli Hong, Neil P. Rodrigues, Lorenza Lazzari, Gillian E. May, Sten Eirik W. Jacobsen, Tariq Enver
Journal: Blood (2009)
Maintenance Therapy in Advanced Ovarian Cancer: Progression-Free Survival and Clinical Benefit
Authors: Robert F. Ozols
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.03.039 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12829660 Maintenance Therapy in Advanced Ovarian Cancer: Progression-Free Survival and Clinical Benefit Robert F. OzolsxRobert F. OzolsSearch for articles by this author Show More Fox Chase Cancer Center, Philadelphia, PA https://doi.org/10.1200/JCO.2003.03.039 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
IODODERMA FROM IODIZED OIL
Authors: GEORGE H. BELOTE
Journal: JAMA (1927)

Since the introduction by Sicard and Forestier<sup>1</sup>of iodized oil as an aid in roentgen-ray diagnosis, it has been very widely used in connection with the roentgen ray, not only in the spinal canal but also in various other organs and structures of the body as a diagnostic procedure. The French preparation lipiodol, and the Danish preparation iodumbrin, are said to be very closely similar in that they contain approximately equal amounts of iodine (40 per cent), and in that they are both highly stable. The relative stability of these compounds is evidenced by the few reports of untoward symptoms following their use during the five years of their employment. Here and there one finds fever and dyspnea reported immediately after the use of these oils. O. Lichtwitz<sup>2</sup>reported a rapidly progressive pulmonary tuberculosis which flared up after their use, and Moeller and von Magnus<sup>3</sup>and Armand-DeLille
The Predictive Value of Intraventicular Dyssynchrony in Response to Levosimendan Therapy in Patients with Decompensated Heart Failure
Authors: Zehra Güven Çetin, Mustafa Çetin, Müslüm Şahin, Emrullah Kızıltunç, Muhammed Bora Demirçelik, Hülya Çiçekçioğlu, Özgül Uçar, Ender Örnek, Feridun Vasfi Ulusoy
Journal: Journal of the American College of Cardiology (2013)