Albright's Hereditary Osteodystrophy Comprising Pseudohypoparathyroidism and Pseudo-pseudohypoparathyroidism
Authors: JOEL B. MANN
Journal: Annals of Internal Medicine (1962)

Review1 February 1962Albright's Hereditary Osteodystrophy Comprising Pseudohypoparathyroidism and Pseudo-pseudohypoparathyroidismWith a Report of Two Cases Representing the Complete Syndrome Occurring in Successive GenerationsJOEL B. MANN, M.D., SEYMOUR ALTERMAN, M.D., A. GORMAN HILLS, M.D.JOEL B. MANN, M.D.Search for more papers by this author, SEYMOUR ALTERMAN, M.D.Search for more papers by this author, A. GORMAN HILLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-315 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSome 20 years ago Albright, Burnett, Smith, and Parson (1) first called attention to a syndrome in which certain skeletal abnormalities coexist with chemical and clinical findings characteristic of hypoparathyroidism. The chemical derangements (hypocalcemia, hyperphosphatemia) found in all three cases originally reported were refractory to correction by administration of parathyroid extract. Parathyroid biopsy obtained from their first patient, after treatment with dihydrotachysterol had corrected the hypocalcemia, disclosed normal parathyroid histology. The authors inferred that the renal tubule was failing to respond to an adequate quantity of circulating parathyroid hormone, and christened the condition "pseudohypoparathyroidism." Subsequently Elrick and others (2), reporting...References1. ALBRIGHTBURNETTSMITHPARSON FCHPHW: Pseudohypoparathyroidism—an example of 'Seabright-Bantam Syndrome.' Endocrinology 30: 922, 1942. Google Scholar2. ELRICKALBRIGHTBARTTERFORBESREEVES HFFCAPJD: Further studies on pseudohypoparathyroidism: report of four new cases. Acta Endocr. 5: 199, 1950. CrossrefMedlineGoogle Scholar3. CUSMANOBAKERFINBY JVDHN: Pseudohypoparathyroidism. Radiology 67: 845, 1956. 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Hormone Res. 8: 379, 1953. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Miami, FloridaFrom the Section of Endocrinology and Metabolism, Department of Medicine, University of Miami School of Medicine, Coral Gables, Florida, and the Combined Diabetic-Endocrine-Metabolic Clinics, Jackson Memorial Hospital, Miami 36, Florida.Supported by Training Grant 2A-5061 and Research Grant A-2442 of the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U. S. Department of Health, Education, and Welfare.Requests for reprints should be addressed to A. Gorman Hills, M.D., Department of Medicine, University of Miami School of Medicine, Jackson Memorial Hospital, Miami 36, Florida. 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