tbuckley/cabot-search huggingface dataset:
TCT-138 Clopidogrel Pretreatment in Non ST Elevation Acute Coronary Syndroms: no effect on mortality, decrease in ischemic endpoints at a price of more major bleeding.
Authors: Anne Bellemain-Appaix, Stephen A. O'Connor, Johanne Silvain, Michel Cucherat, Jean-Philippe Collet, Francois Bernasconi, Gilles Montalescot
Journal: Journal of the American College of Cardiology (2013)
Statistical analysis of epidemiologic data of pregnancy outcomes.
Authors: W J Butler, L A Kalasinski
Journal: Environmental Health Perspectives (1989)

In this paper, a generalized logistic regression model for correlated observations is used to analyze epidemiologic data on the frequency of spontaneous abortion among a group of women office workers. The results are compared to those obtained from the use of the standard logistic regression model that assumes statistical independence among all the pregnancies contributed by one woman. In this example, the correlation among pregnancies from the same woman is fairly small and did not have a substantial impact on the magnitude of estimates of parameters of the model. This is due at least partly to the small average number of pregnancies contributed by each woman.
Case of Malignant Disease of the Humerus
Authors: W. Newnham
Journal: BMJ (1844)

The subject of the following observations was in his 17thyear-was a youth of considerable talent and most amiable manifestations of mind; lie bad distinguished himself at Harrow, and was equally admired and beloved by those who knew him.Generally speaking, he was a very healthy person, blut when he returned home from Harrow, at the Eas- ter tiaiion of 184, he was out of healtb, and com- plWed of headache, and of inability to fix his atten- tion upon his usual objects of study, without bringing on Piia of the Wibehead, and general distress of the nelouis ytem.fli pulse *as rather feeble, but not 9ulckene; a4 the tongue was not loaded, but whitish; in ftAt, a cerebral tongue; and it seemeed evident that thi ain had been overworked.The principles of treatment were very clear, viz., to moderate the work f the biain, and to rouse its energies, so as to bear with impunity the ordinary studious habits of an aspiring `vWd talented young man.He did not retirn to Haio* after the recess, but remained under my eai' till I could conscieptiously give him his " exeat " fret home, and allow him to resume his scholastic dtitie.PSeviousy to his return, he consulted me one day in gay last, for an affection of the upper arm, which he IO$ me; he had hurt while playing with his sisters.Icosifes I thouit little of this injury, believed ftto lie an undue stretching, or, perhaps, rupture of a few ow the fibres of the deltid, and trusting that quiet andtpatience wouId soon mnake all right again, I pre-spibe4 some liniment, and thought I should hear no He returned tn THarrow, whoner T enntinued to re. eegod accounts of him from time to time.Again in Aput le came home, and his anxious friends were *mmed4tely struck by his not looking well; by the powerlessness of his arm; by the pain produced when it W apted to be placed in certain positions, and by th ft elicited from him, as a matter of history, t*,t .pyhvcommunicated to the arm gave him grt pain.I. a. happmeed that just at this period I had left bome on a tour inl search of health, and, in conse- qiencea of this absence, he was taken to town to an em_esit Surgeon, well known to the family, and of whom, as they were -well aware, I entertained the Aighet osplk opinion.Another surgeon being at his
CLINICAL IMPACT OF TISSUE PROTRUSION AFTER STENT IMPLANTATION: AN ADAPT-DES IVUS SUBSTUDY
Authors: Fuyu Qiu, Gary Mintz, Bernhard Witzenbichler, David Metzger, Michael Rinaldi, Peter Duffy, Giora Weisz, Thomas Stuckey, Bruce Brodie, Ke Xu, Ajay Kirtane, Gregg Stone, Akiko Maehara
Journal: Journal of the American College of Cardiology (2014)
(14) Skin pigmentation due to minocycline therapy for acne vulgaris
Authors: Sarah C.F. Rogers, Mary M.M. McCabe
Journal: British Journal of Dermatology (1984)

Journal Article (14) Skin pigmentation due to minocycline therapy for acne vulgaris Get access Sarah C.F. Rogers, Sarah C.F. Rogers City of Dublin Skin and Cancer Hospital, Dublin Search for other works by this author on: Oxford Academic Google Scholar Mary M.M. McCabe Mary M.M. McCabe St Vincent's Hospital, Dublin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Pages 59–61, https://doi.org/10.1111/j.1365-2133.1984.tb05284.x Published: 01 July 1984
Can China's Health Care Be Transplanted without China's Economic Policies?
Authors: Robert J. Blendon
Journal: New England Journal of Medicine (1979)

China's economic policies of the past 25 years have shaped its present health-care system. China's leadership has decided to have neither a national health-insurance system nor a national health service. Instead, it decided that its health system would mirror the workings of its industrial and agricultural system. Decisions to minimize imports, ban private economic activity, assign university graduates on a compulsory basis, control wages, maintain a large domestic standing army and prevent professions or universities from acquiring independent status led directly to the present system of medical care. Consequently, transplantation of China's striking achievements in health-care delivery to the United States or other countries is unlikely to occur in the absence of transfer of the underlying economic policies.
Scottish GPs will not manage budgets for secondary services
Authors: B. Christie
Journal: BMJ (1998)

The first clear signs that a devolved Scotland will develop its health service along different lines from the rest of Britain have appeared in the government's recently published NHS white paper Designed to Care .

The paper was substantially revised after the decision by the Scottish electorate in September to vote in favour of devolution, and, although many common strands remain between the Scottish and English white papers, there are also important differences. Unlike their counterparts in England, Scottish GPs are not being allowed to manage budgets …
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease
Authors: Scott M. Wilson, Bula Bhattacharyya, Rivka A. Rachel, Vincenzo Coppola, Lino Tessarollo, Deborah B. Householder, Colin F. Fletcher, Richard J. Miller, Neal G. Copeland, Nancy A. Jenkins
Journal: Nature Genetics (2002)
Use of the capture-recapture technique to evaluate the completeness of systematic literature searches
Authors: P. Spoor, M. Airey, C. Bennett, J. Greensill, R. Williams
Journal: BMJ (1996)

CommentThe presence of HIV in semen has been well documented,2 3 but the relation between the viral load in semen and peripheral blood CD4 counts is not a simple one.'No studies have looked at the serial viral load of genital fluids during treatment for other sexually transmitted diseases, although a single case report has suggested that chlamydial urethritis may increase shed- ding of HIV-1 in the semen.4Our results help explain how transmission of HIV may be facilitated by concomitant sexually transmitted diseases and add further support for an aggressive approach to treating sexually transmitted diseases in HIV infected patients, as a means of reducing transmission of HIV and for reinforcing the benefits of using condoms.5
Further Perspectives on Concierge Medicine
Authors: Marcy Zwelling-Aamot
Journal: Annals of Internal Medicine (2010)

Letters17 August 2010Further Perspectives on Concierge MedicineMarcy Zwelling-Aamot, MDMarcy Zwelling-Aamot, MDFrom American Academy of Private Physicians, Glen Allen, VA 23058.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-4-201008170-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Thanks to Stillman for his reasoned article on concierge medicine (1). His questions about whether working more directly for our patients actually results in better-quality care at a lower overall cost are just and appropriate. We believe that it does, and some literature supports this. Back in 2006, the Journal of Ambulatory Care Management published an article by Wasson and Baker (2) that said that collaborative care, a centerpiece of direct care, was associated with better blood pressure management, blood glucose level, and serum cholesterol level, as well as better control of pain and emotional issues. The ...References1. Stillman M. Concierge medicine: a “regular” physician's perspective. Ann Intern Med. 2010;152:391-2. [PMID: 20231570] LinkGoogle Scholar2. Wasson JH, Baker NJ. Balanced measures for patient-centered care. J Ambul Care Manage. 2009;32:44-55. [PMID: 19104293] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From American Academy of Private Physicians, Glen Allen, VA 23058.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoConcierge Medicine: A “Regular” Physician's Perspective Michael Stillman Further Perspectives on Concierge Medicine Robert A. Swerlick Further Perspectives on Concierge Medicine Robert P. Fields Further Perspectives on Concierge Medicine Christine Harter Further Perspectives on Concierge Medicine James Bowers Further Perspectives on Concierge Medicine Harry M. Walen Metrics 17 August 2010Volume 153, Issue 4Page: 275-276KeywordsCholesterolConflicts of interestDecision makingEmotionsGlucoseHealth careHealth care qualityLower back painPatient advocacyPatients ePublished: 17 August 2010 Issue Published: 17 August 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
TCT-13 Final Five Year Results From The All-comer COMPARE Trial: A Prospective, Randomized Trial of Everolimus-Eluting vs. Paclitaxel-Eluting Stents
Authors: Pieter C. Smits, Kaiyum Sheikjoesoef, Kees-Jan Royaards, Georgios Vlachojannis, Elvin Kedhi, Jochem Wassing, Eugene P. McFadden, Carlos Van Mieghem, Martin van der Ent
Journal: Journal of the American College of Cardiology (2013)
Prenatal and molecular diagnosis of hemophilia B
Authors: Ji-Hsiung Young, Jyh-Chwan Wang, Jyh-Pyng Gau, Han-Tien Hu
Journal: American Journal of Hematology (1996)

Prenatal diagnosis was carried out on a woman who had previously given birth to a son with a spontaneous mutation of C → T transition at nt 31133 of the factor IX (F.IX) gene. The diagnosis was performed on chorionic villi sampling by the method of amplification-created restriction site (ACRS). It revealed a female fetus with a normal F.IX gene, as confirmed by DNA sequencing after delivery. Meanwhile, a survey using the ACRS method to evaluate the inheritance of 63 individuals from 8 hemophilia B families was done. A different single-point mutation in each family was proved by DNA sequencing. One individual had a mutation with a naturally-created restriction site. In each of the remaining patients, we were able to show an enzyme-cutting site in their DNA amplification product for ACRS with the designed mutagenesis primers. All patients and carriers could be diagnosed accurately by comparing ACRS results with clinical and laboratory findings. There were new novel mutations among the patients. © 1996 Wiley-Liss, Inc.
Abstract 3451: Interactions between N-myc and Sox9 promote medulloblastoma and determine cell fate decisions in cerebellar neural stem cells
Authors: Fredrik J. Swartling, Anders I. Persson, Jasmine Lau, Paul A. Northcott, Matthew R. Grimmer, Louis Chesler, Arie Perry, Joanna J. Phillips, Michael D. Taylor, William A. Weiss
Journal: Cancer Research (2011)

Abstract The proto-oncogene MYCN (N-myc in mice) regulates normal brain development, and is often misexpressed in childhood brain tumors, including medulloblastoma. While most medulloblastoma arise independently of Sonic hedgehog (Shh), about ∼25% of are Shh-dependent and have a more favorable prognosis. We recently induced Shh-independent classic and large cell anaplastic medulloblastoma by driving MYCN from the glial Glutamate Transporter 1 promoter in a tet-regulated transgenic mouse model (Swartling et al, 2010). To characterize cell of origin, we used BrdU labeling in premalignant transgenic mice, demonstrating increased proliferation in cerebellar Bergmann glial cells. Bergmann glia showed high levels of glial marker GFAP as well as the transcription factor Sox9. Whereas neural stem cells (NSCs) from normal perinatal cerebellum contained a high proportion of Sox9-positive cells, primary cultures of tumor spheres showed low levels of Sox9, suggesting that MYCN suppresses Sox9 during medulloblastoma progression. To clarify mechanism, we transduced wild-type (WT) or mutationally-stabilized N-myc-T58A into GFAP-positive NSCs from perinatal murine cerebellum. Transplantation of N-myc-WT NSCs was insufficient for tumor formation. N-myc-T58A cerebellar NSCs generated both Shh-dependent and Shh-independent medulloblastoma, as a function of prenatal or postnatal cerebellar age, respectively. Expression of Sox9 correlated directly with Sonic Hedgehog (Shh) dependence in both murine and human medulloblastoma samples. In addition, forced expression of Sox9 induced Shh-dependence and self-renewal in the Shh-negative mouse medulloblastoma spheres. Our data suggest 1). A glial cell of origin for MYCN-driven medulloblastoma, and 2). Sox9 as a critical target for MYCN during medulloblastoma initiation, with activation of Sox9 leading to Shh-dependence, and inhibition of Sox9 leading to Shh-independent medulloblastoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3451. doi:10.1158/1538-7445.AM2011-3451
Randomized angiographic trial of recombinant tissue-type plasminogen activator (alteplase) in myocardial infarction
Authors: Robert J. Carney, Gregory A. Murphy, Thomas R. Brandt, Patrick J. Daley, Ernest Pickering, Harvey J. White, Timothy J. McDonough, Suzanne K. Vermilya, Sam L. Teichman
Journal: Journal of the American College of Cardiology (1992)
Chemoembolization for intermediate HCC: Is there proof of survival benefit?
Authors: Alejandro Forner, Josep M. Llovet, Jordi Bruix
Journal: Journal of Hepatology (2011)

Hepatocellular carcinoma (HCC) results in more than 600,000 deaths per year. Transarterial embolisation(TAE) and transarterial chemoembolisation (TACE) have become standard loco-regional treatments for unresectable HCC.To assess the beneficial and harmful effects of TACE or TAE.We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Cancer Network register,The Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, Science Citation Index Expanded, and The Latin American Caribbean Health Sciences Literature(LILACS) from dates of inceptions up to September 2010.We considered for inclusion all randomised trials that compared TACE or TAE versus placebo, sham, or no intervention.Co-interventions were allowed if comparable between intervention groups. Trials with inadequate randomisation were excluded.For all-cause mortality, we calculated the log hazard ratio (HR) with standard error as point estimate and pooled them for meta-analysis using the inverse variance method. Sub-group analyses were performed regarding intervention regimen, trial truncation, or co-interventions. We validated the results with trial sequential analyses. We used random-effects model in all meta-analyses in anticipation of statistical heterogeneity among the trials.We included nine trials with 645 participants. Six trials assessed TACE versus control and three trials assessed TAE versus control. Seven trials had low risk of selection bias based on adequate generation of allocation sequence and concealment – but all these trials had other risks of bias. Three trials were stopped early due to interim inspections and one due to slow accrual. For all-cause mortality,statistical heterogeneity between trials was low to moderate(I2) = 30%). Meta-analysis of trials with low risk of selection bias showed that TACE or TAE versus control does not significantly increase survival (HR 0.88; 95% CI 0.71–1.10). Two trials with low risk of selection bias, no early stopping, and no co-intervention did not establish any significant effect of TACE or TAE on overall survival(hazard ratio 1.22, 95% confidence interval 0.82–1.83; P = 0.33). Trials equential analysis confirmed the absence of evidence for a beneficial effect of TACE or TAE on survival indicating the need for future randomisation of up to 383 additional participants. Substantial differences in criteria for assessing tumor response did not allow quantitative analyses. One trial investigated quality of life but did not detect any significant differences between the intervention groups. A range of adverse events including post-embolisation syndrome and serious complications were reported. AUTHORS’There is no firm evidence to support or refute TACE or TAE for patients with unresectable HCC. More adequately powered and bias-protected trials are needed.
Treatment of Acute Graves Orbitopathy
Authors: Michael Kazim, Stephen Trokel, Sally Moore
Journal: Ophthalmology (1991)

The therapeutic options for the treatment of acute Graves orbitopathy include high-dose oral corticosteroids, surgical decompression, and radiotherapy. The former two treatments are associated with significant morbidity. Although there have been a number of reports of the efficacy of radiotherapy, its role in the management of this disease is still questioned. The authors reviewed 84 cases of acute Graves orbitopathy treated with either high-dose systemic corticosteroids or radiotherapy (2000 rad to each involved orbit). Radiotherapy resulted in significant improvement in subjective and objective signs of orbital congestion and was more effective than high-dose corticosteroids in relieving compressive optic neuropathy. Of the patients with compressive optic neuropathy, only 1 of 29 treated with radiotherapy required surgical decompression, whereas, 6 of 16 treated with corticosteroids required surgery. This study suggests that radiotherapy has greater efficacy and fewer complications than highdose systemic corticosteroids in the treatment of acute Graves orbitopathy.
ABNORMAL REFLEXES CAUSED BY MORPHIN POISONING IN A TABETIC
Authors: MICHAEL OSNATO
Journal: JAMA (1918)

The patient is a physician, aged 48, married. He is bedridden and undoubtedly has a well advanced case of tabes, in the paralytic stage. The diagnosis has been confirmed by serologic and spinal fluid examinations, both of which have been performed under the supervision of Major Joseph Collins at the Neurological Institute. Mentally, the patient shows a pure acute depression. For a number of weeks prior to the taking of the overdose of morphin, he had been talking of committing suicide, lamenting his fate and the hopelessness of his condition. He cried a great deal, and was irritable and complaining. For several days before taking the morphin he had suffered from moderately severe laryngeal and cardiac crises, and also from root pains in both lower extremities. His memory was good and there was no mental deterioration. There was no expansiveness, no excitement other than the agitated depression, and there were
DO WE DRAIN TOO FREQUENTLY IN PELVIC SURGERY?
Authors: W. H. HUMISTON
Journal: JAMA (1898)

Since the publication of a few cases in the February, 1898, number of the<i>Medical Council</i>, I have had a series of pus cases, some of which were of such a serious nature, and of such a virulent infection, that a most thorough test of non-drainage of these cases has been made, and the results in all have been satisfactory and beyond my expectation. I am fully alive to the fact that there must be a certain (small) percentage of our cases in which death can not be averted whatever the technique may be, but on the other hand I am assured from the careful study of my own, and the cases of other surgeons, during the past five years, that the mortality in pelvic surgery has been kept too high,<i>partly</i>by the indiscriminate use of some form of drainage. Lawson Tait says, "That there is an inevitable mortality
THE MODERN SUBJECTION OF SCIENCE AND EDUCATION TO PROPAGANDA.
Authors: WM. T. SEDGEWICK
Journal: JAMA (1902)

One of the sad pages in the history of science and education is that which relates how, on the death of Alexander the Great, the teacher of his youth, the much greater Aristotle, rightly regarded by the Middle Age as the "master of those who know" when more than sixty years old was driven from Athens into exile by a patriotic propaganda of the anti-Macedonians. A darker and a bloody page tells how Hypatia of Alexandria, the beautiful and learned daughter of Theon, was cruelly and brutally murdered in a Christian church in the year 415 of our era as a victim of a fanatical propaganda against paganism, condoned, if not conducted, by the Christian Archbishop Cyril, Patriarch of Alexandria. Copernicus hesitated long before publishing his splendid discoveries on the movements of the heavenly bodies and the heliocentric theory, for fear of ecclesiastical interference, and when soon after Galileo, more
Acute Renal Infection in Women: Treatment with Trimethoprim-Sulfamethoxazole or Ampicillin for Two or Six Weeks
Authors: WALTER E. STAMM
Journal: Annals of Internal Medicine (1987)

We compared the efficacy of orally administered ampicillin, 2 g/d, with that of trimethoprim-sulfamethoxazole, 320 mg/d-1600 mg/d, given for 2 or 6 weeks for outpatient management of acute uncomplicated renal infection in women. Of 98 women participating in the trial, 60 had renal infections with susceptible strains, complied with drug therapy, and completed 6 weeks of follow-up. Before treatment, 39 women had symptoms and signs of acute pyelonephritis; 21 had symptoms of cystitis but positive tests for antibody-coated bacteria. All 60 women had alleviation of symptoms and resolution of bacteriuria after 7 days of therapy. Subsequent recurrences occurred in 12 of 27 women given ampicillin, compared with 4 of 33 given trimethoprim-sulfamethoxazole (p= 0.008). Serotyping showed that most recurrences were reinfections with ampicillinresistant strains. With each drug, a 2-week regimen of therapy proved as efficacious as a 6-week regimen, but the longer regimen was less well tolerated. We conclude that a 2-week treatment regimen is sufficient to manage acute pyelonephritis in outpatients and that trimethoprim-sulfamethoxazole is preferable to ampicillin therapy.
Chikungunya Virus Spreading in the Caribbean and South America
Authors: M. J. Friedrich
Journal: JAMA (2014)

A major outbreak of the mosquito-borne chikungunya virus, which causes fever and debilitating joint pain, is occurring in a growing number of countries and territories in the Caribbean and South America since its arrival in the Western Hemisphere in December 2013 (http://1.usa.gov/1pWoglc).
Gene expression profiling of plasma cells at myeloma relapse from tandem transplantation trial Total Therapy 2 predicts subsequent survival
Authors: Bijay Nair, John D. Shaughnessy, Yiming Zhou, Marie Astrid-Cartron, Pingping Qu, Frits van Rhee, Elias Anaissie, Yazan Alsayed, Sarah Waheed, Klaus Hollmig, Jackie Szymonifka, Nathan Petty, Antje Hoering, Bart Barlogie
Journal: Blood (2009)
THE FUTURE OF THE MEDICAL PROFESSION
Authors: J. Brown
Journal: BMJ (1918)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following THE FUTURE OF THE MEDICAL PROFESSION Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.