tbuckley/cabot-search huggingface dataset:
Transduction of Fetal Mice With a Feline Lentiviral Vector Induces Liver Tumors Which Exhibit an E2F Activation Signature
Authors: Reba Condiotti, Daniel Goldenberg, Hilla Giladi, Temima Schnitzer-Perlman, Simon N Waddington, Suzanne MK Buckley, Denise Heim, Wing Cheung, Matthew Themis, Charles Coutelle, Alina Simerzin, Emma Osejindu, Henning Wege, Michael Themis, Eithan Galun
Journal: Molecular Therapy (2013)

Lentiviral vectors are widely used in basic research and clinical applications for gene transfer and long-term expression; however, safety issues have not yet been completely resolved. In this study, we characterized hepatocarcinomas that developed in mice 1 year after in utero administration of a feline-derived lentiviral vector. Mapped viral integration sites differed among tumors and did not coincide with the regions of chromosomal aberrations. Furthermore, gene expression profiling revealed that no known cancer-associated genes were deregulated in the vicinity of viral integrations. Nevertheless, five of the six tumors exhibited highly significant upregulation of E2F target genes, of which a majority are associated with oncogenesis, DNA damage response, and chromosomal instability. We further show in vivo and in vitro that E2F activation occurs early on following transduction of both fetal mice and cultured human hepatocytes. On the basis of the similarities in E2F target gene expression patterns among tumors and the lack of evidence implicating insertional mutagenesis, we propose that transduction of fetal mice with a feline lentiviral vector induces E2F-mediated major cellular processes that drive hepatocytes toward uncontrolled proliferation culminating in tumorigenesis.
Development of a diagnostic role for a clinical nurse specialist
Authors: N.N. Goyal, G.B. Colver
Journal: British Journal of Dermatology (2007)

Journal Article Development of a diagnostic role for a clinical nurse specialist Get access N.N. Goyal, N.N. Goyal Department of Dermatology, Royal Liverpool & Broadgreen University Hospitals NHS Trust, Liverpool, U.K. *Department of Dermatology, Chesterfield Royal Hospital, Chesterfield, U.K. Correspondence: N.N. Goyal. E‐mail: madhunil11@aol.com, nilesh.goyal@rlbuht.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar G.B. Colver G.B. Colver Department of Dermatology, Royal Liverpool & Broadgreen University Hospitals NHS Trust, Liverpool, U.K. *Department of Dermatology, Chesterfield Royal Hospital, Chesterfield, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 5, 1 May 2007, Pages 1060–1061, https://doi.org/10.1111/j.1365-2133.2007.07785.x Published: 01 May 2007
Arg16Gly Polymorphism of the β2-adrenergic Receptor Gene Does Not Modulate Clinical Response to Salmeterol in Subjects with Asthma
Authors: E BLEECKER, H NELSON, J CORREN, M KRAFT, S YANCEY, H ORTEGA, D REILLY, A EMMETT, W ANDERSON
Journal: Journal of Allergy and Clinical Immunology (2008)
Clinical Analysis of Immediate Hypersensitivity to Hydrolyzed Wheat Proteins in Soap
Authors: Akiko Yagami, Masashi Nakamura, Kayoko Suzuki, Akiyo Sano, Masaru Arima, Yohei Iwata, Tsukane Kobayashi, Kazuhiro Hara, Kayoko Matsunaga
Journal: Journal of Allergy and Clinical Immunology (2015)
Exercise Capacity and the Risk of Death in Women
Authors: Martha Gulati, Dilip K. Pandey, Morton F. Arnsdorf, Diane S. Lauderdale, Ronald A. Thisted, Roxanne H. Wicklund, Arfan J. Al-Hani, Henry R. Black
Journal: Circulation (2003)

Cardiovascular disease is the leading cause of death among women and accounts for more than half of their deaths. Women have been underrepresented in most studies of cardiovascular disease. Reduced physical fitness has been shown to increase the risk of death in men. Exercise capacity measured by exercise stress test is an objective measure of physical fitness. The hypothesis that reduced exercise capacity is associated with an increased risk of death was investigated in a cohort of 5721 asymptomatic women who underwent baseline examinations in 1992.Information collected at baseline included medical and family history, demographic characteristics, physical examination, and symptom-limited stress ECG, using the Bruce protocol. Exercise capacity was measured in metabolic equivalents (MET). Nonfasting blood was analyzed at baseline. A National Death Index search was performed to identify all-cause death and date of death up to the end of 2000. The mean age of participants at baseline was 52+/-11 years. Framingham Risk Score-adjusted hazards ratios (with 95% CI) of death associated with MET levels of <5, 5 to 8, and >8 were 3.1 (2.0 to 4.7), 1.9 (1.3 to 2.9), and 1.00, respectively. The Framingham Risk Score-adjusted mortality risk decreased by 17% for every 1-MET increase.This is the largest cohort of asymptomatic women studied in this context over the longest period of follow-up. This study confirms that exercise capacity is an independent predictor of death in asymptomatic women, greater than what has been previously established among men. The implications for clinical practice and health care policy are far reaching.
Abstract 1720: Maritoclax, a selective Mcl-1 inhibitor, sensitizes melanoma cells to the Bad BH3-mimetic ABT-737.
Authors: Manoj K. Pandey, Krishne Gowda, Kenichiro Doi, Arun Sharma, Hong-Gang Wang, Shantu Amin
Journal: Cancer Research (2013)

Abstract Melanoma is the most aggressive form of skin cancer. Despite the development of the therapies it remains one of the most invasive and highly drug resistance cancers. The dysregulation of apoptosis are thought to be one barrier to effective systemic treatment of melanoma. The overexpression of anti-apoptotic Bcl-2 family proteins has been associated with inferior survival, poor prognosis and chemoresistance of several cancers including malignant melanoma. ABT-737, a small-molecule inhibitor of Bcl-2, Bcl-xL and Bcl-w, has demonstrated efficacy in several forms of hematological and non-hematological cancers. However, the efficacy of ABT-737 is diminished in cancer cells with high levels of Mcl-1, another anti-apoptotic member of the Bcl-2 family. The overexpression of Mcl-1 is frequently observed in melanoma and therefore, specifically targeting of Mcl-1 may overcome the resistance of ABT-737. In this study, we investigated the effects of Maritoclax, a novel Mcl-1-selective inhibitor, alone and in combination with ABT-737, on the survival of human melanoma cells. The treatments of Maritoclax reduce the cell viabilities of melanoma cells with an IC50 of between 2.2-5.0μM. Further, treatment of melanoma cells with 2.5 μM Maritoclax for 24 h showed significant decrease in Mcl-1 expression. We found that Maritoclax is able to induce apoptosis in melanoma cells in a caspase-dependent manner. Moreover, Maritoclax induces Mcl-1 degradation via the proteasome system, which is associated with its pro-apoptotic activity. Importantly, Maritoclax markedly enhances the efficacy of ABT-737 against melanoma cells. As a single agent, ABT-737 was not efficient in killing UACC 903 cells with IC50 values of &amp;gt;30 μm. However, in combination with a sub-optimal dose of Maritoclax (2.5μM), the efficacy of ABT-737 was enhanced (IC50 1.3 μm). Similarly, Maritoclax potentiated apoptotic effects of ABT-737 from 20%-71% and 18%-62% when measured by Live and Dead and annexin-V assay, respectively. Taken together, these results suggest that targeting of Mcl-1 by Maritoclax may represent a new therapeutic strategy to sensitize melanoma cells to ABT-737-induced apoptosis. Citation Format: Manoj K. Pandey, Krishne Gowda, Kenichiro Doi, Arun Sharma, Hong-Gang Wang, Shantu Amin. Maritoclax, a selective Mcl-1 inhibitor, sensitizes melanoma cells to the Bad BH3-mimetic ABT-737. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1720. doi:10.1158/1538-7445.AM2013-1720
TRANSCATHETER AORTIC VALVE IMPLANTATION FOR PATIENTS WITH ELLIPTICAL AORTIC ANNULUS
Authors: Kentaro Hayashida, Erik Bouvier, Thierry Lefèvre, Bernard Chevalier, Thomas Hovasse, Mauro Romano, Philippe Garot, Yusuke Watanabe, Arnaud Farge, Patrick Donzeau–Gouge, Bertrand Cormier, Marie–Claude Morice
Journal: Journal of the American College of Cardiology (2013)
Helen Macfarlane Thompson (nee Mair)
Authors: J. A M Findlay, G. N Dutton
Journal: BMJ (2008)

On the point of taking her MRCOG, Helen Macfarlane Thompson (nee Mair) sailed to India with her husband, Bryan ( BMJ 2008;337:a912; doi:10.1136/bmj.a912), in 1955, and served a poor rural population in St Luke’s Hospital …
Eccrine angiomatous hamartoma of the fingers with nail destruction
Authors: E. Sezer, R.D. Koseoglu, N. Filiz
Journal: British Journal of Dermatology (2006)

Journal Article Eccrine angiomatous hamartoma of the fingers with nail destruction Get access E. Sezer, E. Sezer Departments of Dermatology and Pathology, Gaziosmanpasa University School of Medicine, Tokat 60100, Turkey E‐mail: eseze@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar R.D. Koseoglu, R.D. Koseoglu Departments of Dermatology and Pathology, Gaziosmanpasa University School of Medicine, Tokat 60100, Turkey Search for other works by this author on: Oxford Academic Google Scholar N. Filiz N. Filiz Departments of Dermatology and Pathology, Gaziosmanpasa University School of Medicine, Tokat 60100, Turkey Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 5, 1 May 2006, Pages 1002–1004, https://doi.org/10.1111/j.1365-2133.2006.07199.x Published: 01 May 2006
Interaction of cardiopulmonary and carotid baroreflex control of vascular resistance in humans.
Authors: R G Victor, A L Mark
Journal: Journal of Clinical Investigation (1985)

Previous studies in experimental animals indicate an important inhibitory interaction between cardiopulmonary and arterial baroreflexes. In the dog, for example, cardiopulmonary vagal afferents modulate carotid baroreflex control of vascular resistance. On the other hand, previous studies in human subjects have not produced convincing evidence of a specific interaction between these baroreceptor reflexes. The purpose of this study was to determine whether unloading of cardiopulmonary baroreceptors in humans with nonhypotensive lower body negative pressure selectively augments the reflex vasoconstrictor responses to simulated carotid hypotension produced by neck pressure. In nine healthy subjects, we measured forearm vascular responses with plethysmography during lower body negative pressure alone (cardiopulmonary baroreflex), during neck pressure alone (carotid baroreflex), and during concomitant lower body negative pressure and neck pressure (baroreflex interaction). Lower body negative pressure produced a greater than twofold augmentation of the forearm vasoconstrictor response to neck pressure. This increase in resistance was significantly greater (P less than 0.05) than the algebraic sum of the increase in resistance from lower body negative pressure alone plus that from neck pressure alone. In contrast, lower body negative pressure did not potentiate the forearm vasoconstrictor responses either to intra-arterial norepinephrine or to the cold pressor test. Thus, the potentiation of the vasoconstrictor response to neck pressure by lower body negative pressure cannot be explained by augmented reactivity to the neurotransmitter or to a nonspecific augmentation of responses to all reflex vasoconstrictor stimuli. In conclusion, nonhypotensive lower body negative pressure selectively augments carotid baroreflex control of forearm vascular resistance. These experiments demonstrate a specific inhibitory cardiopulmonary-carotid baroreflex interaction in humans.
The Renal Response to Streptococcal Infection.
Authors: Philip Freedman
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970The Renal Response to Streptococcal Infection.Philip Freedman, M.D., H. Peter Meister, M.D., Hwa Ja Lee, M.D., Earl Smith, M.D., Bun Siu Co., M.D., Bernard Nidus, M.D.Philip Freedman, M.D., H. Peter Meister, M.D., Hwa Ja Lee, M.D., Earl Smith, M.D., Bun Siu Co., M.D., Bernard Nidus, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-802_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA prospective study was conducted on patients with streptococcal infection to determine the prevalence and degree of renal involvement as compared and contrasted with classical clinical acute poststreptococcal glomerulonephritis. A total of 1,246 patients presenting with sore throat were identified as suffering from beta hemolytic streptococcal infection. Six hundred fifteen patients returned on at least 1 occasion for examination, and significant urinary abnormalities were found in 191. Three hundred five patients attended regularly for follow-up, and 103 were admitted for further study. In 55 patients in whom renal biopsy was performed, edema was present in 10, hypertension in 7, bilateral... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Philip Freedman, M.D.; H. Peter Meister, M.D.; Hwa Ja Lee, M.D.; Earl Smith, M.D.; Bun Siu Co., M.D.; Bernard Nidus, M.D.Affiliations: Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 802-802KeywordsBiopsyEdemaGlomerulonephritisHypertensionPharyngitisProspective studiesStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
Chromosomes and causation of human cancer and leukemia: XXVIII. Value of detailed chromosome studies on large numbers of cells in CML
Authors: Shin‐Ichi Sonta, Avery A. Sandberg
Journal: American Journal of Hematology (1977)

Abstract Comparison of the chromosome findings obtained on routine examination (10‐50 cells) of the marrows from patients with Ph 1 ‐positive CML with those based on a large number (110‐500 cells) of metaphases in six of these patients, in whom appropriate material was available, revealed the presence of small percentages of aneuploid cells in the marrow during the chronic phase of the disease and not seen with the routine procedure. These aneuploid cells may ultimately constitute the dominant clone during the blastic phase of the chronic myelocytic leukemia (CML). Furthermore, karyotypically abnormal cells, in addition those observed on routine study, were detected in the blastic phase when a large number of cells was examined. The value and implications of these observations are discussed.
Effects of assisted ventilation on the work of breathing: volume-controlled versus pressure-controlled ventilation.
Authors: G Cinnella, G Conti, F Lofaso, H Lorino, A Harf, F Lemaire, L Brochard
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

During assisted ventilation, the same tidal volume can be delivered in different ways, with the possibility for the physician to vary the ventilatory target (pressure or volume) and the peak flow setting. We compared the effects on the respiratory work rate of assisted ventilation, delivered either with a square wave flow pattern (assist control ventilation [ACV]) or with a decelerating flow pattern and a constant pressure (assisted pressure-control ventilation [APCV]). In the first part of the study where seven patients were studied, inspiratory time and tidal volume were similar in the two modes of ventilation. High and moderate levels of tidal volume (VT) were studied (12 ml/kg and 8 ml/kg, respectively). To obtain moderate VT, inspiratory time was kept constant and, therefore, mean inspiratory flow was reduced. At high VT, no difference between ACV and APCV was noted for breathing pattern, respiratory drive indexes, respiratory muscle work, or arterial blood gases. All patients exhibited respiratory alkalosis. At moderate VT, normal pH was achieved. In this situation significantly lower levels were observed during APCV than during ACV for the power of breathing (10 +/- 2 versus 19 +/- 5 J/min, p<0.05), transdiaphragmatic pressure swing (7 +/- 1 versus 11 +/- 2 cm H2O, p<0.05), and pressure-time index (252 +/- 43 versus 484 +/- 114 cm H2O.s, p<0.05), even though breathing pattern and gas exchange were similar. In the second part of the study where six additional patients were studied, tidal volume was kept constant at a moderate level (8 ml/kg), and we studied the effect of shortening inspiratory time and increasing mean inspiratory flow. At moderate VT and high inspiratory flow, no significant differences could be found between ACV and APCV, and although pressure-time index tended to be lower during APCV, absolute levels of effort were of small magnitude (56 +/- 55 versus 76 +/- 55 cm H2O.s). We conclude that at moderate VT and low flow rates only, inspiratory assistance delivered at a constant pressure reduces the respiratory work rate more effectively than assist control ventilation.
Risk factors for developing non-insulin dependent diabetes: a 10 year follow up of men in Uppsala.
Authors: E T Skarfors, K I Selinus, H O Lithell
Journal: BMJ (1991)

OBJECTIVE--To analyse anthropometric and metabolic characteristics as risk factors for development of non-insulin dependent diabetes mellitus in middle aged normoglycaemic men. DESIGN--Prospective population study based on data collected in a health survey and follow up 10 years later. SETTING--Uppsala, a middle sized city in Sweden. SUBJECTS--2322 men aged 47-53, of whom 1860 attended the follow up 7-14 years later, at which time they were aged 56-64. MAIN OUTCOME MEASURES--Incidence of non-insulin dependent diabetes. RESULTS--In a multivariate logistic regression analysis, variations of 1 SD from the mean of the group that remained euglycaemic were used to calculate odds ratios and 95% confidence intervals. Blood glucose concentration 60 minutes after the start of an intravenous glucose tolerance test (odds ratio = 5.93, 95% confidence interval 3.05 to 11.5), fasting serum insulin concentration (2.12, 1.54 to 2.93), acute insulin increment at an intravenous glucose tolerance test (1.71, 1.21 to 2.43), body mass index (1.41, 1.01 to 1.97), and systolic blood pressure (1.23, 0.97 to 1.56) were independent predictors of diabetes. In addition, the use of antihypertensive drugs at follow up (selective or unselective beta blocking agents, thiazides, or hydralazine) was an independent risk factor (1.70, 1.11 to 2.60). CONCLUSIONS--Metabolic and anthropometric characteristics associated with or reflecting insulin resistance as well as a poor acute insulin response to glucose challenge were important predictors of future diabetes in middle aged men. Antihypertensive drugs were found to constitute a further, iatrogenic risk factor.
A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome
Authors: Makiko Meguro, Akiko Kashiwagi, Kohzoh Mitsuya, Mitsuyoshi Nakao, Ikuko Kondo, Shinji Saitoh, Mitsuo Oshimura
Journal: Nature Genetics (2001)
Induction of human B cell antigens in non-T cell acute lymphoblastic leukemia.
Authors: L M Nadler, J Ritz, M P Bates, E K Park, K C Anderson, S E Sallan, S F Schlossman
Journal: Journal of Clinical Investigation (1982)

Leukemic cells from 70% of patients with Ia+CALLA+ non-T cell acute lymphoblastic leukemia (ALL) express an antigen (B1) found on all normal B lymphocytes. In this study, ALL cells that do not express the B1 antigen were studied in an attempt to further elucidate the cellular lineage of these tumors. Non-T cell ALL lines and tumor cells isolated from patients with non-T cell ALL that are Ia + CALLA + B1- were studied in vitro with a variety of agents known to promote cellular differentiation. Phorbol diester (TPA) or phytohemagglutinin conditioned leukocyte culture media were capable of inducing the expression of B1 on all four non-T cell ALL lines tested. In contrast, B1 could not be induced under the identical conditions on a promyelocytic leukemia line or a T cell lymphoblastic leukemia line. With the induction of B1 on non-T cell ALL lines, cytoplasmic mu-heavy chain (c mu) became undetectable, whereas the expression of CALLA and Ia were unchanged. The expression of B1 was accompanied by a decrease of cellular proliferation and DNA synthesis, but not significant morphologic changes were noted. In addition, no other B or T cell antigens were detected. The cellular origin of non-T cell ALL was further investigated using tumor cells isolated from leukemic patients. Tumor cells from eight patients with Ia + CALLA + B1-c mu- ALL could be induced in vitro with TPA to express both B1 and c mu. In contrast, cells from five patients with Ia + CALLA-B1-c mu- non-T cell ALL could not be induced with TPA to express CALLA, B1 or c mu. These studies suggest that the non-T cell ALL are heterogeneous and represent a spectrum of early B cell differentiation including the pre- pre-B cell (Ia + CALLA + B1-c mu-), the intermediate pre-B cell (Ia + CALLA +B1 + c mu-), and finally the "true" pre-B cell (Ia + CALLA + B1 + c mu+). The cellular origin of the remaining Ia + CALLA-B1-c mu- form of non-T cell ALL (20%) is still unknown.
Reply to the Letter to the Editor from Watanabe et al
Authors: Alberto Malesci, Luigi Laghi, Paolo Bianchi
Journal: Clinical Cancer Research (2008)

In Response: Dr. Watanabe and colleagues argue that we might have underestimated the actual prognostic benefit conferred by tumor microsatellite instability (MSI; ref. [1][1]), because the vast majority of MSI cancers were in the proximal colon, a tumor location possibly associated with poorer
Clinical Dermatology: Diagnosis and Therapy of Common Skin Diseases
Authors: Philip C. Anderson
Journal: JAMA (1983)

Many excellent dermatology textbooks have been written in the last few years. In the best of these, the student learns of current medical knowledge with the author's own interpretation of the utility of these facts supported by references to the best in up-to-date basic science. In the Fitzpatrick textbook (<i>Dermatology in General Medicine</i>, New York, McGraw-Hill, 1979), for example, appreciation and anticipation of new research is contagious. In these important regards this textbook by Vasarinsh, concerned primarily with terminology, classification, and descriptions of skin diseases, seems old-fashioned. Often the list of supporting references is too short and favors the more general review articles of lesser value, in my opinion, and so the sense of a logically essential underlying science is lost in many sections. The beginning student seeking a very general and practical clinical textbook knowledgably written and thoughtfully traditional may examine this new 744-page Canadian offering. The pictures are
An episode of transient neurological symptoms
Authors: C. B Josephson, R. A.-S. Salman, S. J Phillips
Journal: BMJ (2009)

A 72 year old, right handed man presented with weakness of the right hand and difficulty expressing himself, although he was able to comprehend those around him. The symptoms were maximal at onset and resolved spontaneously within one hour. He had a history of hypertension and type 2 diabetes mellitus. His only drugs were metformin and a thiazide diuretic. His neurological and general examinations were normal, and his blood pressure was 140/90 mm Hg. Computed tomography of his brain was normal. ### Short answers