tbuckley/cabot-search huggingface dataset:
Adopting Gayet’s Techniques of Totally Laparoscopic Liver Surgery in the United States
Authors: Andrew A. Gumbs, Brice Gayet
Journal: Liver Cancer (2013)

Professor Brice Gayet of the Institut Mutualiste Montsouris in Paris, France, has developed totally laparoscopic techniques for all segments of the liver. As a pioneer in the field of minimally invasive hepato-pancreato-biliary surgery, he started a Minimally Invasive Hepato-Pancreato-Biliary Fellowship in 2006. A retrospective review of all hepatic cases performed by a single surgeon since completing this Fellowship was undertaken. From November 2007 to October 2012, a total of 80 liver resections were done, of which 73 were begun with the intention of completing the case laparoscopically. Of these, more than 90% were completed laparoscopically and 88% were for malignant disease. One of the foundations of Professor Gayet's techniques is the low lithotomy or 'French' position and the utilization of a small robotically controlled laparoscope holder that is sterilizeable and considerably more economic than complete surgical systems. Prototypes exist of robotically controlled hand-held laparoscopic instruments that, unlike the complete surgical system, enable surgeons to maintain a sense of touch (haptics). Proper training in minimally invasive hepato-pancreato-biliary techniques can be obtained with surgeons able to independently perform laparoscopic major hepatectomies without senior minimally invasive backup. Furthermore, miniature and more affordable robotics may enable more surgeons to enjoy the benefits of minimally invasive surgery while maintaining patient safety and minimizing the rising burden of health-care costs worldwide.
Case 47-1969
Authors: Nicholas M. Nelson, Allan L. Friedlich, David L. Page
Journal: New England Journal of Medicine (1969)

Presentation of CaseA four-week-old male infant was admitted to the hospital because of respiratory distress.He was the product of a full-term, uneventful gestation and uncomplicated delivery. The weight at birth was 3.64 kg. He was apparently healthy; the only problem was intermittent vomiting after feeding. Five days before admission, when seen for a routine examination, he was active, with normal color. The pulse was 120; no cardiac murmurs were heard. The liver was felt 3 fingerbreadths below the right costal margin, and the spleen was palpable below the left costal margin. Three days later he vomited in the . . .
Disulfiram for the Treatment of Alcoholism
Authors: RICHARD K. FULLER
Journal: Annals of Internal Medicine (1979)

One hundred twenty-eight alcoholic men were assigned randomly to receive either a regular dose of disulfiram (250 mg), a pharmacologically inactive dose (1 mg), or no disulfiram. There were no statistically significant differences among the three treatment groups in total abstinence, percentage of drinking days, days worked, family stability (living with same relative), or percent of scheduled appointments kept. However, 21% of those who received the regular dose of disulfiram and 25% who received the pharmacologically inactive dose remained abstinent, whereas only 12% of those who received no disulfiram did so. These results indicate that disulfiram may be of limited value in the treatment of alcoholism, fear of the disulfiram-ethanol reaction is important in preventing drinking, and patients willing to take disulfiram are more likely to be abstinent if given the drug. We also found that complete abstinence correlated significantly with compliance and obtaining employment.
Viral warts, herpes simplex and herpes zoster in patients with secondary immune deficiencies and neoplasms
Authors: WARWICK L. MORISON
Journal: British Journal of Dermatology (1975)

The incidence of viral warts, recurrent herpes simplex and herpes zoster has been assessed in a group of patients with possible secondary immune deficiency states and compared to a control group. Patients with cell-mediated immune deficiency appear to be more prone to warts and zoster infection as compared to patients with humoral immune deficiency. Recurrent herpes simplex infection was not increased in either group.
Coronary Artery Disease: What is a Reasonable Diagnostic Strategy?
Authors: WILLIAM B. STASON
Journal: Annals of Internal Medicine (1981)

Editorials1 September 1981Coronary Artery Disease: What is a Reasonable Diagnostic Strategy?WILLIAM B. STASON, M.D., M.S., HARVEY V. FINEBERG, M.D., PH.D.WILLIAM B. STASON, M.D., M.S., HARVEY V. FINEBERG, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-3-385 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe evaluation of patients with suspected coronary artery disease has important implications not only for the individual but also for society. A recent conference sponsored by the National Center for Health Care Technology ("Coronary Artery Bypass Surgery: Economic, Ethical, and Social Issues," Washington, D.C., 21-23 April 1981.) addressed clinical and economic questions on the "reasonable workup" of the patient with suspected coronary artery disease. Our views on this perplexing problem are summarized here.The choice of a diagnostic strategy is complicated both by the broad clinical spectrum of the disease and by the wide variety of diagnostic options available to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM B. STASON, M.D., M.S.; HARVEY V. FINEBERG, M.D., PH.D.Affiliations: Harvard School of Public Health Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byACC/AHA guidelines for cardiac catheterization and cardiac catheterization laboratoriesACC/AHA guidelines for cardiac catheterization and cardiac catheterization laboratories. American College of Cardiology/American Heart Association Ad Hoc Task Force on Cardiac Catheterization. 1 September 1981Volume 95, Issue 3Page: 385-386KeywordsCoronary arteriesHealth careHealth economicsStable coronary artery diseaseSurgery ePublished: 1 December 2008 Issue Published: 1 September 1981 PDF downloadLoading ...
Thyroid Antibodies in Cerebrospinal Fluid
Authors: R. Hall, S. G. Owen
Journal: BMJ (1960)

We recently had the opportunity of examining the spinal fluid from a patient with neurosyphilis and coincident Hashimoto's disease.Antibody to thyroglobulin was detected in appreciable concentration and has since been found in the C.S.F. of four other patients with autoimmune thyroiditis. MethodsAntibody to thyroid protein was estimated, using an adaptation of the tannic acid haemagglutination technique (Boyden, 1951; B3oyden and Sorkin, 1955).
THE EFFECTS OF ADRENAL MASSAGE ON BLOOD-PRESSURE
Authors: R. G. HOSKINS
Journal: JAMA (1913)

In spite of considerable evidence to the contrary, the opinion widely prevails that adrenal secretion has exclusively a pressor effect on vascular tension. From time to time since Oliver and Schaefer first investigated the subject, different observers have reported that dilute solutions of adrenal extract cause a fall of arterial pressure; but this effect has been ascribed to general depressants which occur in almost any tissue extract. For instance, Moore and Purington reported in 1900 that extracts of adrenal glands from the ox when given in minute dosage cause in the dog a fall of pressure, but that when larger amounts are used the effect is a rise. 1   More recently Elliott 2 has noted that stimulation of the splanchnic nerves in the cat results not only in augmented pressure due to vasoconstriction in the abdominal viscera, but also in a secondary fall of pressure due to liberation of epinephrin
Increased coronary sinus temperature in patients with significant atherosclerotic lesions in left coronary artery determined by a new technique: The coronary sinus thermography
Authors: Manolis Vavouranakis, Eleftherios Tsiamis, Sophia Vaina, Konstantinos Toutouzas, John Gialafos, Harrisios Boudoulas, Pavlos Toutouzas, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2003)
Factors influencing the long-term prognosis of treated patients with variant angina.
Authors: D D Waters, D D Miller, J Szlachcic, A Bouchard, M Méthé, J Kreeft, P Théroux
Journal: Circulation (1983)

To determine the prognosis of variant angina and the factors influencing it, 169 consecutive patients hospitalized in our coronary unit were followed for a mean of 15.3 months (range 1 to 68). Survival at 1, 2, and 3 years was 95%, 90%, and 87%, respectively; survival without myocardial infarction was 80%, 78%, and 75%. Twenty of the 22 myocardial infarctions and eight of the 14 deaths occurred within the first 3 months. Mantel-Haenszel log-rank analysis demonstrated that coronary disease, ventricular function, and the degree of disease activity were significant interdependent variables that influenced both survival and survival without infarction. At 1, 2, and 3 years, survival for patients with multivessel disease was 81%, 76%, and 66%; for patients with one-vessel disease, 97%, 92%, and 92%; and for patients without stenoses greater than or equal to 70%, 98% at each year (p = .0003). Survival without infarction at 1 year was 88% in patients with no stenoses greater than or equal to 70% and 82% in patients with single-vessel disease; it did not change thereafter in either group, but was 62%, 58%, and 50% at 1, 2, and 3 years in patients with multivessel disease (p = .001). Treatment did not influence survival in any subgroup (only 14 patients died overall) or survival without infarction in patients with multivessel disease. However, in patients without multivessel disease, treatment with nifedipine, diltiazem, and verapamil improved survival without infarction compared to treatment with perhexiline maleate or long-acting nitrates alone (92% vs 67% at 1, 2, and 3 years; p less than .005). Thus in addition to preventing angina, nifedipine, diltiazem, and verapamil appear to reduce complications in patients with variant angina without multivessel disease.
Corneal repair by human corneal keratocyte-reprogrammed iPSCs and amphiphatic carboxymethyl-hexanoyl chitosan hydrogel
Authors: Yueh Chien, Yi-Wen Liao, Dean-Mo Liu, Heng-Liang Lin, Shih-Jen Chen, Hen-Li Chen, Chi-Hsien Peng, Chang-Min Liang, Chung-Yuan Mou, Shih-Hwa Chiou
Journal: Biomaterials (2012)
Isolated Antibody to Hepatitis B Surface Antigen and Response to Hepatitis B Vaccination
Authors: BARBARA G. WERNER
Journal: Annals of Internal Medicine (1985)

To determine the need for immunization of health workers with antibody to hepatitis B surface antigen (anti-HBs) as their only serologic marker of previous hepatitis B exposure, we studied the level, persistence, and immunologic specificity of isolated anti-HBs in 46 persons identified during screening for hepatitis B vaccine. We rescreened these persons 1 year later, administered a single dose of hepatitis B vaccine, and determined the anti-HBs level at 1, 2, and 8 weeks after vaccination. Isolated anti-HBs levels were low and antibody did not persist; 22 subjects tested had lost detectable anti-HBs within 19 months even though immunologic specificity was shown in vitro in 34. Anamnestic responses suggesting previous exposure and immunity were seen in only 10 subjects; 5 of these subjects had moderate-level, persistent anti-HBs. Although some persons with naturally acquired, isolated anti-HBs may be protected from hepatitis B, the immunologic specificity and protective value of anti-HBs, especially when levels are low, remain questionable.
Workplace Demands, Economic Reward, and Progression of Carotid Atherosclerosis
Authors: John Lynch, Niklas Krause, George A. Kaplan, Riitta Salonen, Jukka T. Salonen
Journal: Circulation (1997)

Background Characteristics of the work environment have been associated with cardiovascular morbidity and mortality, but it is unclear whether these factors are associated with preclinical manifestations of disease. Methods and Results We investigated the association between job demands, economic reward, and the 4-year progression of carotid atherosclerosis in a population-based sample of 940 Finnish men. Data from the Kuopio Ischemic Heart Disease Risk Factor Study were used to estimate changes in plaque height, maximum and mean intima-media thicknesses across combinations of job demands, and income. Associations were examined in relation to atherosclerotic risk factors and were stratified by baseline levels of atherosclerosis and prevalent ischemic heart disease. Men who had jobs with high demands and low economic rewards had significantly greater 4-year progression of plaque height (0.33 mm, P =.008) and maximum intima-media thickness (0.32, P =.03) than men with low-demand, high-income jobs. The magnitude of these differences was not greatly attenuated by risk factor adjustment and did not differ when examined by the level of workplace resources, social support, or employment status. Larger differences were observed in a subsample of men who had more advanced atherosclerosis at baseline. Conclusions These results show that men with demanding work that produces little economic reward have significantly greater progression of carotid atherosclerosis than more advantaged men. The relationship between job demands and health should be understood in a broad framework of interacting economic conditions, social circumstances, and behaviors that cascade over the life course and may ultimately contribute to socioeconomic inequalities in morbidity and mortality.
Trends in head injuries among child bicyclists
Authors: W R Pitt, S Thomas, J Nixon, R Clark, D Battistutta, C Acton
Journal: BMJ (1994)

Wearing of approved helmets by bicyclists has been recently made compulsory in several states in Australia and the United States, and similar legislation is being promoted in the United Kingdom. Those against helmets argue that they are not effective in collisions with motor vehicles. Evidence supporting helmet legislation has included decreases in the number of head injuries associated with wearing a helmet1 and a reduction in the risk of bicycle related head injury among helmet wearers in a case-control study.2 We examined trends in the incidence of head injuries and bicycle related injuries in Brisbane children by using injury surveillance …
Farbmetrische Untersuchungen amnioskopischer Beleuchtungsquellen
Authors: J. Dudenhausen
Journal: Endoscopy (1970)

The greenish tint cast of glass fiber illumination systems simulated a greenish coloration of the amniotic fluid during initial experiments. Therefore, this type of illumination was not considered suitable for amnioscopy. Using a procedure from colourmetrics, various glass fiber illumination systems were compared. The “Endolux” Light Projector 10301 and the “Cold Light Fontäne Universal” are glass fiber illumination systems which – expecially in the high switch steps – adequately meet the demands of amnioscopy.
The Reemergence of Smokeless Tobacco
Authors: Gregory N. Connolly, Deborah M. Winn, Stephen S. Hecht, Jack E. Henningfield, Bailus Walker, Dietrich Hoffmann
Journal: New England Journal of Medicine (1986)

Smokeless tobacco (snuff and chewing tobacco) is reemerging as a popular form of tobacco, particularly among male adolescents. In different regions of the United States, from 8 to 36 percent of male high-school students are regular users. The use of smokeless tobacco has been shown to cause oral-pharyngeal cancer. The strongest link is with cancers of the cheek and gum. White mucosal lesions (leukoplakia) are found in 18 to 64 percent of users, often at the site where the tobacco was held. Other associations have been suggested for cancers of the esophagus, larynx, and pancreas. Nitrosamines, found in high concentrations in smokeless tobacco, most likely have a role in its carcinogenicity. Other health problems include periodontal disease, acute elevations of blood pressure, and dependence. In early 1986, after action at the state level, Congress enacted a federal law requiring health-warning labels on packages of smokeless tobacco and a ban on electronic advertising. Other regulatory measures under consideration include raising state and federal excise taxes, tightening controls on advertising, and prohibiting sales to minors. In view of the recent growth of this problem, policy makers are taking the opportunity to intervene with preventive measures to protect a new generation of tobacco users.
Aspirin for Asymptomatic Carotid Artery Stenosis
Authors: Robert G. Hart
Journal: Annals of Internal Medicine (1996)

Letters1 September 1996Aspirin for Asymptomatic Carotid Artery StenosisRobert G. Hart, MD and Diane H. Solomon, MDRobert G. Hart, MDUniversity of Texas Health Sciences Center, San Antonio, TX 78217Search for more papers by this author and Diane H. Solomon, MDUniversity of Texas Health Sciences Center, San Antonio, TX 78217Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Cote and colleagues [1] did not cite the relevant results of a randomized trial from the Mayo Clinic [2] that involved patients with asymptomatic carotid stenosis and was stopped prematurely because of reduced myocardial infarction (P < 0.01) in patients given aspirin, 80 mg/d, compared with those who had carotid endarterectomy and received no aspirin (most myocardial infarctions were unrelated to surgery). Presumably, many of the 533 patients who did not participate in this study because of a medical requirement for aspirin had manifest coronary artery disease. This condition may have contributed to the unusual predominance of ...References1. Cote R, Battista RN, Abrahamowicz M, Langlois Y, Bourque F, Mackey A, et al. Lack of effect of aspirin in asymptomatic patients with carotid bruits and substantial carotid narrowing. Ann Intern Med. 1995; 123:649-55. Google Scholar2. Results of a randomized, controlled trial of carotid endarterectomy for asymptomatic carotid stenosis. Mayo Clinic Asymptomatic Carotid Endarterectomy Study Group. Mayo Clin Proc. 1992; 67:513-8. Google Scholar3. Collaborative overview of randomized trials of antiplatelet therapy. Antiplatelet Trialists Collaboration. BMJ. 1994; 308:81-106. Google Scholar4. Final report on the aspirin component of the ongoing Physician Health Study. Steering Committee of the Physician Health Study Research Group. N Engl J Med. 1991; 325:445-53. Google Scholar Author, Article, and Disclosure InformationAuthors: Robert G. Hart, MD; Diane H. Solomon, MDAffiliations: University of Texas Health Sciences Center, San Antonio, TX 78217 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1996Volume 125, Issue 5Page: 420KeywordsAspirinCarotid arteriesCarotid endarterectomyClinical trialsMyocardial infarctionRandomized trialsStable coronary artery diseaseStenosisSurgery ePublished: 15 August 2000 Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
WHO's crisis handling to be overhauled after slow response to Ebola
Authors: A. Gulland
Journal: BMJ (2015)

International health leaders have voted for reorganisation at the World Health Organization in the wake of its poor initial handling of the epidemic of Ebola virus disease in west Africa.

At a special session of WHO’s executive board, delegates passed a resolution to overhaul the organisation’s emergency response, including the establishment of a 1500 strong global health reserve workforce and a $100m (£66m; €89m) contingency fund. Many delegates spoke of WHO’s poor crisis handling capacity, with Tom Frieden, director of the US Centers for Disease Control and Prevention speaking on behalf of the US government, saying, “The WHO we have is not the one we need.”

A spokesman for the charity Medecins Sans Frontieres told the meeting that thousands of people had died from the disease because of “international negligence,” adding, “It has become alarmingly evident that there is no functioning global response mechanism to a potential pandemic in countries with fragile …
Zoxazolamine — A Potent Uricosuric Agent
Authors: Elizabeth B. Reed, Thomas V. Feichtmeir, Forrest M. Willett
Journal: New England Journal of Medicine (1958)

ZOXAZOLAMINE¶ has been widely used during the past two years for the purpose of decreasing spasm of skeletal muscle, presumably via a depressant effect upon polysynaptic pathways in the central nervous system. Occasional side effects, such as drowsiness, lightheadedness, dizziness, abdominal discomfort, vomiting, headache and transient blotching of the skin, are transitory, and the most troublesome, the gastrointestinal symptoms, are usually avoided by administration of the drug with food. No changes in blood pressure, respiration, blood count, urinalysis tests or of hepatic and renal function were noted in the clinical study by Amols.1 Serious toxicity is apparently absent, and the . . .
Abstract 3159: ZAR2 transcriptionally represses the ATPase ATP6V0A4 to negatively regulate invasiveness of breast cancer cells
Authors: Smita Misra, Gautam Chaudhuri
Journal: Cancer Research (2014)

Abstract ZAR2 is a recently characterized RNA-dependent transcriptional repressor protein that is implicated in the cell cycle-dependent regulation of BRCA2 gene expression. We have shown previously that ZAR2 mRNA is transcribed from the overlapping bi-directional promoter of the BRCA2 gene, binds to the overlapping promoter and prevents the expression of BRCA2 through chromatin remodeling. ZAR2 level is significantly low in the invasive breast cancer cells and tissues as compared to the non-invasive cells. Knockdown of ZAR2 in the non-invasive breast cancer cells increased the in vitro invasiveness of these cells whereas forced expression of ZAR2 in the invasive breast cancer cells prevented their invasiveness. To understand the possible mechanism of ZAR2-mediated regulation of invasiveness of the breast cancer cells we studied differential gene expression in the ZAR2 knocked down non-invasive breast cancer cells by RNA-seq analysis. One of the genes that are significantly elevated in the ZAR2 knocked down cells is the invasion determining enzyme ATP6V0A4. ATP6V0A4 is transcribed from an overlapping bi-directional promoter along with its partner TMEM213 in the breast cancer cells. We found that both ATP6V0A4 and TMEM213 levels are increased in the ZAR2 knocked down cells whereas cells with forced expression of ZAR2 have a significant decrease in the levels of these proteins. ZAR2 cell cycle dependently binds to the ATP6V0A4/TMEM213 gene promoter to repress the activity of this bi-directional promoter. This study thus reports a new pathway for the regulation of the invasiveness of breast cancer cells. Supported in part by DOD grants BC990678 and BC050641 to GC and NIH grant 1U54RR026140 to SM. Citation Format: Smita Misra, Gautam Chaudhuri. ZAR2 transcriptionally represses the ATPase ATP6V0A4 to negatively regulate invasiveness of breast cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3159. doi:10.1158/1538-7445.AM2014-3159