tbuckley/cabot-search huggingface dataset:
Site of Reentry in Paroxysmal Supraventricular Tachycardia in Man
Authors: BRUCE N. GOLDREYER, J. THOMAS BIGGER
Journal: Circulation (1971)

His bundle recordings during spontaneous and induced episodes of paroxysmal supraventricular tachycardia (SVT) demonstrated that the site of reentry responsible for this arrhythmia was in the A-V node. In five patients studied, A-V conduction time and refractory periods were normal, but atrial premature depolarizations (APD) within a portion of the relative refractory period of the A-V node consistently produced atrial reentry—echoes or sustained SVT. In two patients, APDs falling within the A-V effective refractory period failed to excite the His bundle but still reentered within the A-V node and began SVT. It was noted that the various relationships between atrial and ventricular depolarizations on the surface ECG did not reflect different mechanisms for SVT, but only variations in A-V nodal conduction time.
Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes
Authors: Fong-Yu Cheng, Saprina Ping-Hsien Wang, Chio-Hao Su, Tsung-Liu Tsai, Ping-Ching Wu, Dar-Bin Shieh, Jyh-Horng Chen, Patrick Ching-Ho Hsieh, Chen-Sheng Yeh
Journal: Biomaterials (2008)
Major Bleeding, Mortality, and Efficacy of Fondaparinux in Venous Thromboembolism Prevention Trials
Authors: John W. Eikelboom, Daniel J. Quinlan, Martin O'Donnell
Journal: Circulation (2009)

Background— Bleeding is a strong predictor of death in patients hospitalized for arterial thrombosis who are treated with antithrombotic therapy, but the prognostic importance of bleeding in patients receiving antithrombotic prophylaxis for venous thromboembolism is uncertain. Methods and Results— Using Cox proportional hazards modeling, we examined the association between major bleeding and death at 30 days using pooled individual patient data from 8 large randomized controlled trials (n=13 085) comparing fondaparinux with control (low-molecular-weight heparin or placebo) for the prophylaxis of venous thromboembolism in hospitalized surgical or medical patients. Patients who developed major bleeding were older, were more likely to be male, had a lower body weight and lower creatinine clearance, and were more likely to be receiving fondaparinux. At 30 days, the risk of death was 7-fold higher among patients with a major bleeding event (8.6% versus 1.7%; adjusted hazard ratio, 6.96; 95% confidence interval, 4.60 to 10.51). There was a consistent pattern of reduced mortality in patients treated with fondaparinux irrespective of whether patients experienced major bleeding (6.8% versus 11.4%; hazard ratio, 0.58; 95% confidence interval, 0.27 to 1.23) or no major bleeding (1.5% versus 1.9%; hazard ratio, 0.77; 95% confidence interval, 0.59 to 1.02; P for heterogeneity=0.47). Conclusions— Major bleeding in hospitalized surgical and medical patients participating in venous thromboembolism prevention trials is a strong predictor of mortality.
Adiposity and Sex Hormones in Postmenopausal Breast Cancer Survivors
Authors: Anne McTiernan, Kumar B. Rajan, Shelley S. Tworoger, Melinda Irwin, Leslie Bernstein, Richard Baumgartner, Frank Gilliland, Frank Z. Stanczyk, Yutaka Yasui, Rachel Ballard-Barbash
Journal: Journal of Clinical Oncology (2003)

Purpose: Overweight and obese women with breast cancer have poorer survival compared with thinner women. One possible reason is that breast cancer survivors with higher degrees of adiposity have higher concentrations of tumor-promoting hormones. This study examined the association between adiposity and concentrations of estrogens, androgens, and sex hormone–binding globulin (SHBG) in a population-based sample of postmenopausal women with breast cancer. Methods: We studied the associations between body mass index (BMI), body fat mass, and percent body fat, measured by dual-energy x-ray absorptiometry scan, waist circumference, and waist-to-hip circumference ratio, with concentrations of estrone, estradiol, testosterone, SHBG, dehydroepiandrosterone sulfate, free estradiol, and free testosterone in 505 postmenopausal women in western Washington and New Mexico with incident stage 0 to IIIA breast cancer. Blood and adiposity measurements were performed between 4 and 12 months after diagnosis. Results: Obese women (BMI ≥ 30) had 35% higher concentrations of estrone and 130% higher concentrations of estradiol compared with lighter-weight women (BMI &lt; 22.0; P = .005 and .002, respectively). Similar associations were observed for body fat mass, percent body fat, and waist circumference. Testosterone concentrations also increased with increasing levels of adiposity (P = .0001). Concentrations of free estradiol and free testosterone were two to three times greater in overweight and obese women compared with lighter-weight women (P = .0001). Conclusion: These data provide information about potential hormonal explanations for the association between adiposity and breast cancer prognosis. These sex hormones may be useful biomarkers for weight loss intervention studies in women with breast cancer.
A Surgeon Replies
Authors: Adrian Marston
Journal: Journal of the Royal Society of Medicine (2004)

It is a pity that one phrase, perhaps a rather inept pleasantry in what was on the whole a friendly and sympathetic review, should have provoked sadness. Of course it's true that the College of Physicians never discovered anything— in contrast to the College of Surgeons which through the Institute of Basic Medical Sciences discovered quite a lot, and accumulated some Nobel Prizewinners.
Therapeutic Hypercapnia Reduces Pulmonary and Systemic Injury following <i>In Vivo</i> Lung Reperfusion
Authors: JOHN G. LAFFEY, MOTOSHI TANAKA, DOREEN ENGELBERTS, XIAOPING LUO, SHIZENG YUAN, A. KEITH TANSWELL, MARTIN POST, THOMAS LINDSAY, BRIAN P. KAVANAGH
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Permissive hypercapnia, involving tolerance to elevated PaCO2 , is associated with reduced acute lung injury (ALI), thought to result from reduced mechanical stretch, and improved outcome in ARDS. However, deliberately elevating inspired CO2 concentration alone (therapeutic hypercapnia, TH) protects against ALI in ex vivo models. We investigated whether TH would protect against ALI in an in vivo model of lung ischemia–reperfusion (IR). Anesthetized open chest rabbits were ventilated (standard eucapnic settings), and were randomized to TH (Fi CO2 0.12) versus control (Fi CO2 0.00). PaCO2 and arterial pH values achieved in the TH versus CON groups were 101 ± 3 versus 44.4 ± 4 mm Hg and 7.10 ± 0.03 versus 7.37 ± 0.03, respectively. Following left lung ischemia and reperfusion, TH versus control was associated with preservation of lung mechanics, attenuation of protein leakage, reduction in pulmonary edema, and improved oxygenation. Indices of systemic protection included improved acid–base and lactate profile, in the absence of systemic hypoxemia. In the TH group, mean BALF TNF- α levels were 3.5% of CON levels (p < 0.01), and mean 8-isoprostane levels were 30% of CON levels (p = 0.02). Western blot analysis demonstrated reduced lung tissue nitrotyrosine in TH, indicating attenuation of tissue nitration. Finally, preliminary data suggest that TH may attenuate apoptosis following lung IR. We conclude that in the current model TH is protective versus IR lung injury and mechanisms of protection include preservation of lung mechanics, attenuation of pulmonary inflammation, and reduction of free radical mediated injury. If these findings are confirmed in additional models, TH may become a candidate for clinical testing in critical care.
5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.
Authors: J W Woods, M J Coffey, T G Brock, I I Singer, M Peters-Golden
Journal: Journal of Clinical Investigation (1995)

5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are two key proteins involved in the synthesis of leukotrienes (LT) from arachidonic acid. Although both alveolar macrophages (AM) and peripheral blood leukocytes (PBL) produce large amounts of LT after activation, 5-LO translocates from a soluble pool to a particulate fraction upon activation of PBL, but is contained in the particulate fraction in AM irrespective of activation. We have therefore examined the subcellular localization of 5-LO in autologous human AM and PBL collected from normal donors. While immunogold electron microscopy demonstrated little 5-LO in resting PBL, resting AM exhibited abundant 5-LO epitopes in the euchromatin region of the nucleus. The presence of substantial quantities of 5-LO in the nucleus of resting AM was verified by cell fractionation and immunoblot analysis and by indirect immunofluorescence microscopy. In both AM and PBL activated by A23187, all of the observable 5-LO immunogold labeling was found associated with the nuclear envelope. In resting cells of both types, FLAP was predominantly associated with the nuclear envelope, and its localization was not affected by activation with A23187. The effects of MK-886, which binds to FLAP, were examined in ionophore-stimulated AM and PBL. Although MK-886 inhibited LT synthesis in both cell types, it failed to prevent the translocation of 5-LO to the nuclear envelope. These results indicate that the nuclear envelope is the site at which 5-LO interacts with FLAP and arachidonic acid to catalyze LT synthesis in activated AM as well as PBL, and that in resting AM the euchromatin region of the nucleus is the predominant source of the translocated enzyme. In addition, LT synthesis is a two-step process consisting of FLAP-independent translocation of 5-LO to the nuclear envelope followed by the FLAP-dependent activation of the enzyme.
The printing on the wall
Authors: J O Drife
Journal: BMJ (1994)

Graffitology (the study of graffiti) is now an established subdiscipline of the social sciences, but little attention has been paid to its medical equivalent. Hospital staff, too well behaved to write on walls but nonetheless keen on self expression, decorate their working environment with posters and newspaper cuttings. Their efforts are the subject of the emerging science of bluetackology.

Only selected walls are used. Operating theatres are free of plaques saying YOU DON'T HAVE TO BE MAD TO WORK HERE - BUT IT HELPS!!! and consulting rooms are usually bare in hospital, though not in the community. In a health …
Subacute sclerosing panencephalitis: detection of measles virus sequences in RNA extracted from circulating lymphocytes
Authors: J.-G. Fournier, J. Gerfaux, A.-M. Joret, P. Lebon, S. Rozenblatt
Journal: BMJ (1988)

disorder may therefore play a part in the pathogenesis of both IgA nephropathy and Buerger's disease.3The lymphocytes of our first patient carried HLA B5 antigen, which has been associated with both Buerger's disease4 and, in some cases, familial IgA nephritis.5The association of the two diseases in our patients may not have been coincidental.1 Adar R. Buerger's disease.The need for diagnosis criteria.
BRCA1, LMO4, and CtIP mRNA Expression in Erlotinib-Treated Non–Small-Cell Lung Cancer Patients with EGFR Mutations
Authors: Niki Karachaliou, Carlota Costa, Ana Gimenez-Capitan, Miguel Angel Molina-Vila, Jordi Bertran-Alamillo, Clara Mayo, Bartomeu Massuti, Margarita Majem, Enric Carcereny, Teresa Moran, Jose Javier Sanchez, Santiago Viteri, Amaya Gasco, Luciano Wannesson, John Souglakos, Jose Jimeno, Rafael Rosell
Journal: Journal of Thoracic Oncology (2013)
GW25-e3569 Targeted Delivery of Hydrogen Sulfide Using Ultrasound and Intravenous Microbubbles Attenuates Myocardial Ischemia-reperfusion Injury
Authors: Gangbin Chen, Jianping Bin, Shengcun Guo, Chuanxi Zhang, Yongkang Lu, Yan Wang, Shuxin Shen, Xinzhong Li, Juefei Wu
Journal: Journal of the American College of Cardiology (2014)
Platelet-derived growth factor is involved in the augmentation of airway responsiveness through remodeling of airways in diesel exhaust particulate–treated mice
Authors: Naomi Yamashita, Kentaro Sekine, Takashi Miyasaka, Ruji Kawashima, Yasuyuki Nakajima, Junichi Nakano, Toshiko Yamamoto, Tadashi Horiuchi, Koichi Hirai, Ken Ohta
Journal: Journal of Allergy and Clinical Immunology (2001)
Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning
Authors: K BOENGLER, G DODONI, A RODRIGUEZSINOVAS, A CABESTRERO, M RUIZMEANA, P GRES, I KONIETZKA, C LOPEZIGLESIAS, D GARCIADORADO, F DILISA
Journal: Cardiovascular Research (2005)

Journal Article Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning Get access Kerstin Boengler, Kerstin Boengler aInstitut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Giuliano Dodoni, Giuliano Dodoni bDipartimento di Chimica Biologica, Universita di Padova, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Antonio Rodriguez-Sinovas, Antonio Rodriguez-Sinovas cServicio de Cardiologia, Hospital Vall d'Hebron, Barcelona, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar Alberto Cabestrero, Alberto Cabestrero cServicio de Cardiologia, Hospital Vall d'Hebron, Barcelona, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar Marisol Ruiz-Meana, Marisol Ruiz-Meana cServicio de Cardiologia, Hospital Vall d'Hebron, Barcelona, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar Petra Gres, Petra Gres aInstitut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Ina Konietzka, Ina Konietzka aInstitut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Carmen Lopez-Iglesias, Carmen Lopez-Iglesias cServicio de Cardiologia, Hospital Vall d'Hebron, Barcelona, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar David Garcia-Dorado, David Garcia-Dorado cServicio de Cardiologia, Hospital Vall d'Hebron, Barcelona, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar Fabio Di Lisa, Fabio Di Lisa bDipartimento di Chimica Biologica, Universita di Padova, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Gerd Heusch, Gerd Heusch aInstitut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Rainer Schulz Rainer Schulz * aInstitut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany *Corresponding author. Email address: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 67, Issue 2, August 2005, Pages 234–244, https://doi.org/10.1016/j.cardiores.2005.04.014 Published: 01 August 2005 Article history Received: 21 October 2004 Revision received: 14 March 2005 Accepted: 05 April 2005 Published: 01 August 2005
Heart Rate Response During Positive Exercise Stress Test Predicts Coronary Artery Disease and Its Severity in High- Risk Type 2 Diabetic Patients With Silent Ischemia
Authors: Simonetta Bacci, Tommaso Iangialonga, Massimo Villella, Anna Rauseo, Raffaele Fanelli, Vincenzo Trischitta
Journal: Diabetes Care (2003)

Diagnosis of coronary artery disease (CAD) before symptoms appear can reduce mortality in diabetes (1). ST depression at exercise stress test (EST) independent of angina is a hallmark of CAD (2); however, if a positive EST is characterized by the lack of angina, a second test to better stratify the risk of ischemia is recommended (3). Heart rate response at EST with ST depression can improve risk stratification in the general population (4), but no such data are available in diabetic patients.

We studied the relationship between heart rate response and CAD in 33 consecutive patients with type 2 diabetes and silent ischemia at EST (i.e., horizontal or downsloping ST depression ≥1 mm at 0.08 s after J point, without angina). Patients (22 men and …
Cell Sorting: Microfluidic Cell Sorter (<i>μ</i>FCS) for On‐chip Capture and Analysis of Single Cells (Adv. Healthcare Mater. 4/2012)
Authors: Jaehoon Chung, Huilin Shao, Thomas Reiner, David Issadore, Ralph Weissleder, Hakho Lee
Journal: Advanced Healthcare Materials (2012)

Many cancers shed malignant cells into the circulation. These cancer cells are important for both diagnostic and therapeutic purposes but their purification, quantification and characterization remain challenging. On page 432, Hakho Lee, Ralph Weissleder, and co-workers present a low-cost, rapid microfluidic cell sorter (μFCS) device for the detection and molecular analysis of circulating tumor cells (CTCs). The μFCS efficiently enriches CTCs from unprocessed whole blood, allows on-chip culture and molecular profiling, and provides cell retrieval for subsequent analyses. The potential clinical application of the technology is demonstrated by capturing and genetically analyzing CTCs in tumorbearing mice.
1121-62 Pattern of bracytherapy failure in unselected patients treated with gamma and beta radiation for saphenous vein graft in-stent restenosis
Authors: Jonathan Bridges, Duane S Pinto, Christopher C Pickett, Kalon K Ho, Donald E Cutlip, Roger J Laham, David J Cohen, Joseph P Carrozza
Journal: Journal of the American College of Cardiology (2004)
An extreme failure of concordance
Authors: R. Smith
Journal: BMJ (2003)

Trial results have dramatically reduced HRT useThe publication of the combined oestrogenprogestogen trial from the Women's Health Initiative, which generated extensive media coverage in 2002, has affected women's decisions to use hormone replacement therapy (HRT).In a cross sectional survey of women attending general practices in New Zealand, Lawton and colleagues (p 845) investigated the effect of the publication on the use of HRT in known users.Over half of those surveyed had stopped taking HRT, and stopping was significantly associated with increasing age, use of combined HRT, and use for more than five years.The authors say that women sought appropriate advice from health professionals and that stopping HRT was in line with recommendations in international guidelines.
Recurrent annular erythema with purpura: a new variant of leucocytoclastic vasculitis responsive to dapsone
Authors: B. CRIBIER, J. F CUNY, B. SCHUBERT, A. COLSON, F. TRUCHETET, E. CROSSHANS
Journal: British Journal of Dermatology (1996)

Journal Article Recurrent annular erythema with purpura: a new variant of leucocytoclastic vasculitis responsive to dapsone Get access B. CRIBIER, B. CRIBIER Clinique Dermatologique des Hopitaux Universitaires, l Place de l'Hopital 67091, Strasboury, France Search for other works by this author on: Oxford Academic Google Scholar J. F CUNY, J. F CUNY Services de Dermatologie, CHR Metz‐Thionville, Frence Search for other works by this author on: Oxford Academic Google Scholar B. SCHUBERT, B. SCHUBERT Services de Dermatologie et d'Anatomopathologie, Mulhouse, France Search for other works by this author on: Oxford Academic Google Scholar A. COLSON, A. COLSON Services de Dermatologie et d'Anatomopathologie, Mulhouse, France Search for other works by this author on: Oxford Academic Google Scholar F. TRUCHETET, F. TRUCHETET Services de Dermatologie, CHR Metz‐Thionville, Frence Search for other works by this author on: Oxford Academic Google Scholar E. CROSSHANS E. CROSSHANS Clinique Dermatologique des Hopitaux Universitaires, l Place de l'Hopital 67091, Strasboury, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 6, 1 December 1996, Pages 972–975, https://doi.org/10.1046/j.1365-2133.1996.d01-1105.x Published: 01 December 1996 Article history Accepted: 29 May 1996 Published: 01 December 1996
Heart disease mortality declining with fewer and less deadly attacks
Authors: Z Kmietowicz
Journal: BMJ (1999)

The decline in mortality from coronary heart disease seen in some countries over the past decade is the result of a reduction in the number of events rather than improved survival, according to the 10 year study monitoring trends and determinants in cardiovascular disease (MONICA).

Investigators from the World Health Organisation's MONICA project monitored the trends in coronary heart disease across 37populations …
TREATMENT OF LOCALIZED APPENDICULAR ABSCESS
Authors: KNOTT VAN BUREN
Journal: JAMA (1910)

No attempt shall be made in this brief paper to consider the treatment of appendicitis in detail. The time-worn and hackneyed questions of "When should we operate?" and "When should we delay operation?" will be scrupulously avoided, as will many other phases of this familiar subject. It is my intention to confine these few remarks to a consideration of the question, "Should or should we not remove the appendix in practically every case of localized appendicular abscess?" In perusing the literature on this question, or in attendance at the various surgical clinics throughout the country, we find as probably the most frequently employed plan, the removal of the appendix when it presents itself freely within the confines of the abscess, while in those cases in which it is adherent and buried by the intestinal coils, the operation is limited to simple incision and drainage, leaving the appendix to be removed
Preventive effect of acupuncture on histamine-induced itch: A blinded, randomized, placebo-controlled, crossover trial
Authors: F PFAB, M HAMMES, M BACKER, J HUSSMARP, G ATHANASIADIS, T TOLLE, H BEHRENDT, J RING, U DARSOW
Journal: Journal of Allergy and Clinical Immunology (2005)
Treatment of Primary Pulmonary Hypertension with Nifedipine
Authors: LEWIS J. RUBIN
Journal: Annals of Internal Medicine (1983)

To evaluate the potential value of nifedipine treatment for primary pulmonary hypertension, hemodynamic and scintigraphic measurements were made before and 15 to 30 minutes after nifedipine, 10 to 20 mg, was given sublingually to nine patients. Nifedipine treatment increased cardiac output (mean ± SD, 3.6 ± 1.7 to 5.3 ± 2.8 L/min, p < 0.001) and decreased mean aortic pressure (99 ± 19 to 85 ± 12 mm Hg, p < 0.001) and total pulmonary and total systemic resistances (1605 ± 787 to 1025 ± 540 dyn · s · cm-5 and 2761 ± 1557 to 1591 ± 823 dyn · s · cm-5, respectively; p < 0.005). Heart rate and mean pulmonary arterial pressure did not change significantly. Right ventricular end-diastolic volume decreased 10% (p = 0.01), end-systolic volume decreased 15% (p < 0.01), and right ventricular ejection fraction increased 18% (p < 0.05) in eight patients. After 4 to 14 months (mean, 7.3 ± 3.8) of treatment with nifedipine, 40 to 120 mg/d, in six patients, cardiac output increased (3.6 ± 2.0 to 5.0 ± 1.8 L/min, p < 0.01) and total pulmonary resistance decreased (1572 ± 730 to 987 ± 586 dyn · s · cm-5, p = 0.025), whereas pulmonary arterial pressure remained unchanged (59 ± 23.2 to 55 ± 28.6 mm Hg, p > 0.05) compared with baseline values. We conclude that nifedipine therapy may be useful in the chronic management of patients with primary pulmonary hypertension.