tbuckley/cabot-search huggingface dataset:
Lupus anticoagulant and venous leg ulceration
Authors: A.M. Fink, A. Kottas-Heldenberg, W. Mayer, H. Partsch, P.M. Bayer, R. Bednar, A. Steiner
Journal: British Journal of Dermatology (2002)

Most leg ulcers occur in patients with venous insufficiency. However, not all patients with venous insufficiency develop leg ulcers. Recent studies have found that factors causing clotting abnormalities, e.g. anticardiolipin antibody (ACA), are associated with leg ulcers. Although lupus anticoagulant, like ACA, belongs to the group of antiphospholipid antibodies, its presence in patients with venous leg ulceration has not been previously reported.To determine the presence of lupus anticoagulant in patients with venous leg ulceration.We investigated the presence of lupus anticoagulant in 27 patients with venous leg ulcers and compared these data with controls. Lupus anticoagulant was evaluated in all subjects by the Russell's viper venom test.Of 27 patients with venous leg ulceration, 16 (59%) were shown to have lupus anticoagulant, while only one of 32 controls (3%) was found to have lupus anticoagulant. Thus, lupus anticoagulant was significantly more frequent in patients with venous leg ulcers than in controls (P < 0.001).We suggest that lupus anticoagulant could be a hitherto unknown factor contributing to the development of venous leg ulcers.
SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer
Authors: Guoqiang Li, Weimin Ci, Subhradip Karmakar, Ke Chen, Ruby Dhar, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Yuwen Ke, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Liqun Zhou, Xianghong Li, Matthew F. Calabrese, Edmond R. Watson, Sandip M. Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda A. Schulman, Jiang Liu, Kevin P. White
Journal: Cancer Cell (2014)
Vascular Endothelial Growth Factor Blockade Reduces Intratumoral Regulatory T Cells and Enhances the Efficacy of a GM-CSF–Secreting Cancer Immunotherapy
Authors: Betty Li, Alshad S. Lalani, Thomas C. Harding, Bo Luan, Kathryn Koprivnikar, Guang Huan Tu, Rodney Prell, Melinda J. VanRoey, Andrew D. Simmons, Karin Jooss
Journal: Clinical Cancer Research (2006)

Abstract Purpose: The purpose of the present study was to evaluate granulocyte macrophage colony-stimulating factor (GM-CSF)–secreting tumor cell immunotherapy in combination with vascular endothelial growth factor (VEGF) blockage in preclinical models. Experimental Design: Survival and immune response were monitored in the B16 melanoma and the CT26 colon carcinoma models. VEGF blockade was achieved by using a recombinant adeno-associated virus vector expressing a soluble VEGF receptor consisting of selected domains of the VEGF receptors 1 and 2 (termed sVEGFR1/R2). Dendritic cell and tumor infiltrating lymphocyte activation status and numbers were evaluated by fluorescence-activated cell sorting analysis. Regulatory T cells were quantified by their CD4+CD25hi and CD4+FoxP3+ phenotype. Results: The present study established that GM-CSF–secreting tumor cell immunotherapy with VEGF blockade significantly prolonged the survival of tumor-bearing mice. Enhanced anti-tumor protection correlated with an increased number of activated CD4+ and CD8+ tumor-infiltrating T cells and a pronounced decrease in the number of suppressive regulatory T cells residing in the tumor. Conversely, overexpression of VEGF from tumors resulted in elevated numbers of regulatory T cells in the tumor, suggesting a novel mechanism of VEGF-mediated immune suppression at the tumor site. Conclusion: GM-CSF–secreting cancer immunotherapy and VEGF blockade increases the i.t. ratio of effector to regulatory T cells to provide enhanced antitumor responses. This therapeutic combination may prove to be an effective strategy for the treatment of patients with cancer.
1121 EARLY MARKERS OF METABOLIC SYNDROME ARE ASSOCIATED WITH DISTINCT HCV GENOTYPES, WHILE ABNORMAL GLUCOSE TOLERANCE SUBSTANTIALLY DECREASES THE LIKELIHOOD OF SVR
Authors: E. Jaeckel, E. Zehnter, T. Lutz, A. Carlebach, R. Link, C. John, G. Teuber, W. Schmidt, H.R. Bruch, R. Heyne, P. Geyer, B. Weber, M. Stern, U. Naumann, U. Spengler, C. Herold, A. Stoehr, P. Sandow, S. Stoll, M.P. Manns
Journal: Journal of Hepatology (2012)
Health Care on the Hill — Democrats Set the Agenda
Authors: John K. Iglehart
Journal: New England Journal of Medicine (2007)

Interview with U.S. Representative Jim Cooper on Blue Dog Democrats and health care in the 110th Congress. (06:40)Download Democratic legislators, energized by their new (if slim) majorities in the 110th Congress, now face the daunting challenge of enacting an ambitious policy agenda while fulfilling their pledge to restore "pay-as-you-go" rules to new legislation. Since 2002, when the Republican-controlled Congress let these rules expire, GOP-approved measures have been fueling large annual budget deficits — the three largest in U.S. history in 2003 ($378 billion), 2004 ($413 billion), and 2005 ($318 billion). Restoration of the rules, which House Speaker Nancy Pelosi (D-CA) said she planned to accomplish in the first 100 hours of the new session, will mean that any . . .
Steroid Resistance in Bronchial Asthma
Authors: HOWARD J. SCHWARTZ
Journal: Annals of Internal Medicine (1968)

The eosinopenic response to 40 mg of cortisol given intravenously was studied in 19 unselected asthmatics (group A) and in 6 asthmatics who exhibit clinical resistance to cortisol's antiasthma effect (group B). The changes in total eosinophil counts were -35%, -77%, and -73% in group A; and -10%, -36%, and 3.6% in group B at 2, 4, and 6 hr after administration. Cortisol turnover studies in four subjects from each group were done using a tracer dose of tritium-labeled cortisol immediately followed by 40 mg of unlabeled cortisol intravenously. Plasma levels were measured at 30, 60, 90, and 120 min; 6-hr urine collections were made. Cortisol half-life values in group A were 123, 133, 120, and 132 min; in group B they were 81, 96, 75, and 90 min. Thus, asthma requiring unusually large doses of steroid for control may be associated with a decreased eosinopenic response to cortisol and an accelerated plasma cortisol clearance.
Environmental public health surveillance: possible estuary-associated syndrome.
Authors: L C Backer, A S Niskar, C Rubin, K Blindauer, D Christianson, L Naeher, H S Rogers
Journal: Environmental Health Perspectives (2001)

Public health surveillance involves the collection, analysis, and dissemination of data for use in public health practice. A surveillance system includes the capacity to collect and analyze data as well as the ability to disseminate the data to public health agencies that can undertake effective prevention and control activities. An emerging issue in environmental public health surveillance involves human exposure to the toxins produced by microorganisms present in oceans and estuaries. One of these organisms is Pfiesteria piscicida Steidinger &amp; Burkholder, a dinoflagellate found in estuaries along the Atlantic and gulf coasts of the United States. There have been reports of both human illness associated with occupational exposures to concentrated laboratory cultures of P. piscicida and massive fill kills associated with the presence of the organism in rivers and estuaries. These reports, and anecdotal reports from people who worked on rivers where the organism has been found, generated concern that environmental exposures to P. piscicida, similar organisms, or perhaps a toxin or toxins produced by the organism(s), could cause adverse human health effects. To begin to evaluate the public health burden associated with P. piscicida, investigators from the National Center for Environmental Health at Centers for Disease Control and Prevention and health agencies from states along the Atlantic coast collaborated to develop a passive surveillance system for collecting, classifying, and tracking public inquiries about the organism. Specifically, the group developed exposure and symptom criteria and developed data collection and reporting capabilities to capture the human health parameters collectively referred to as possible estuary-associated syndrome (PEAS). The surveillance system was implemented in six states (Delaware, Florida, Maryland, North Carolina, South Carolina, Virginia) beginning in June 1998. From 1 June 1998 through 30 June 2001, the six state health agencies participating in the PEAS surveillance system received 3,859 calls: 3,768 callers requested information and 91 callers reported symptoms. Five individuals have been identified as meeting PEAS criteria.
PERI-PROCEDURAL OUTCOMES AFTER CAROTID ARTERY STENTING WITH THE FIRST 10,000 PATIENTS ENROLLED IN THE SAPPHIRE WORLDWIDE STUDY NEUROVASCULAR ENDOVASCULAR
Authors: Robert Hibbard, Rasesh Shah, Christopher Metzger, Douglas Massop, Richard Smalling, Majdi Ashchi, Donald Heck
Journal: Journal of the American College of Cardiology (2011)
Local Delivery of Plasmid DNA Into Rat Carotid Artery Using Ultrasound
Authors: Yoshiaki Taniyama, Katsuro Tachibana, Kazuya Hiraoka, Tsunetatsu Namba, Keita Yamasaki, Naotaka Hashiya, Motokuni Aoki, Toshio Ogihara, Kaneda Yasufumi, Ryuichi Morishita
Journal: Circulation (2002)

Background — Although viral vector systems are efficient to transfect foreign genes into blood vessels, safety issues remain in relation to human gene therapy. In this study, we examined the feasibility of a novel nonviral vector system by using high-frequency, low-intensity ultrasound irradiation for transfection into blood vessels. Methods and Results — Luciferase plasmid mixed with or without echo contrast microbubble (Optison) was transfected into cultured human vascular smooth muscle cells (VSMC) and endothelial cells (EC) with the use of ultrasound. Interestingly, luciferase activity was markedly increased in both cell types treated with Optison. We then transfected luciferase plasmid mixed with Optison by means of therapeutic ultrasound into rat artery. Two days after transfection, luciferase activity was significantly higher in carotid artery transfected with luciferase gene with Optison and ultrasound than with plasmid alone. In addition, we transfected an anti-oncogene (p53) plasmid into carotid artery after balloon injury as a model of gene therapy for restenosis. Two weeks after transfection, the intimal-to-medial area ratio in rats transfected with wild-type p53 plasmid complexed with Optison by means of ultrasound was significantly decreased as compared with control, accompanied by a significant increase in p53 protein. No apparent toxicity such as inflammation could be detected in blood vessels transfected with plasmid DNA with ultrasound and Optison. Conclusions — Overall, we demonstrated that an ultrasound transfection method with Optison enhanced transfection efficiency of naked plasmid DNA into blood vessels without any apparent toxicity. Transfection of p53 plasmid with the use of this method should be useful for safe clinical gene therapy without a viral vector system.
Use of Selective Serotonin Reuptake Inhibitors during Pregnancy and Risk of Autism
Authors: Anders Hviid, Mads Melbye, Björn Pasternak
Journal: New England Journal of Medicine (2013)

Studies have raised concern about an association between the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and an increased risk of autism spectrum disorders in the offspring.We conducted a cohort study of all singleton live births in Denmark from 1996 through 2005 (626,875 births), with follow-up through 2009. Using Danish population registries, we linked information on maternal use of SSRIs before and during pregnancy, autism spectrum disorders diagnosed in the offspring, and a range of potential confounders. We used a survival analysis of the time to diagnosis in the offspring with Poisson regression to estimate rate ratios of autism spectrum disorders according to maternal use of SSRIs.During 5,057,282 person-years of follow-up, we identified 3892 cases of autism spectrum disorder (incidence rate, 77.0 per 100,000 person-years). A total of 52 cases during 42,400 person-years of follow-up involved offspring of women who were exposed to SSRIs during their pregnancy (incidence rate, 122.6 per 100,000 person-years). As compared with no use of SSRIs both before and during pregnancy, use during pregnancy was not associated with a significantly increased risk of autism spectrum disorders (fully adjusted rate ratio, 1.20; 95% confidence interval [CI], 0.90 to 1.61). Among women who received SSRIs before pregnancy but not during pregnancy, the corresponding fully adjusted rate ratio was 1.46 (95% CI, 1.17 to 1.81).We did not detect a significant association between maternal use of SSRIs during pregnancy and autism spectrum disorder in the offspring. On the basis of the upper boundary of the confidence interval, our study could not rule out a relative risk up to 1.61, and therefore the association warrants further study. (Funded by the Danish Health and Medicines Authority.).
Management of appendicitis.
Authors: A W Clark
Journal: BMJ (1976)

of an acute episode of abdominal pain and pre- sented the findings at the meeting of the British Paediatric Association in 1975.Briefly, we found that the 235 admissions with acute abdominal pain accounted for 9-4% of nonwaiting-list admissions in that 12-month period.Thirty-one admissions were for chronic or recurrent pain and 204 for acute pain.A breakdown of diagnoses followed the same general pattern as found by Mr Jones and was as follows: Unexplained.360% Appendicitis .28%oUpper respiratory infection (including 7 cases of influenza B) .11Constipation with soiling or urinary retention 3% Gastroenteritis.30 Urinary infection.3,, Mesenteric adenitis .30Major psychological problems 3%' Pneumonia on chest x-ray. . .2% Miscellaneous (including 5 admissions with duodenal ulcer pain) . .8
β‐thalassemia intermedia caused by compound heterozygosity for Hb Malay (β codon 19 AAC→AGC; Asn→Ser) and codons 41/42 (‐CTTT) β <sup>0</sup> ‐thalassemia mutation
Authors: S.K. Ma, Eudora Y.D. Chow, Amy Y.Y. Chan, Nelson N.S. Kung, John S. Waye, L.C. Chan, David H.K. Chui
Journal: American Journal of Hematology (2000)

We report a case of beta-thalassemia intermedia caused by compound heterozygosity for hemoglobin (Hb) Malay and codon 41/42 (-CTTT) beta(0)-thalassemia mutation in a 38-year-old Chinese woman. This patient has long-standing anemia with a baseline Hb level of around 70 g/L. She worked as a full-time cashier and had not required regular blood transfusions. Nevertheless, she had splenomegaly necessitating splenectomy, cholelithiasis, and iron overload. This case illustrates the varied phenotypic expression associated with compound heterozygosity for Hb Malay and other beta-thalassemia mutations. Since Hb Malay migrates as Hb A on electrophoresis and chromatography, this variant Hb mutation ought to be included in the differential diagnosis for beta-thalassemia major or intermedia patients of Southeast Asian descent who are reported to have Hb A on the basis of Hb analysis. The possible presence of this mutation should also be considered in appropriate cases for genetic counseling in couples at risk of conceiving fetuses with beta-thalassemia major or intermedia.
T. violaceum. Infection of the Scalp
Authors: I. Anderson
Journal: BMJ (1957)

JOURNAL 24 hours varied between 46 and 86% of the oral dose, the average being 65%.During these observa- tions no measurements of the urinary pH were made, but no patients received alkalis or acetazolamide whilst being treated with mecamylamine.In view of the fact that human urine is usually acid in reaction, it is not thought that the variations observed were due to any alterations in pH.If it can be assumed that the excretion of mecamylamine reflects its absorption, then these findings suggest that it is fairly consistently and reliably absorbed during continued oral administration.0 O A.J. dT Aged 54.S.V. d' Aged 41. 20 80 °10mg.I.V. urine pH 0-0 8mg.I.V. urine 80 7 5 or above.pH 7 5 or above.* ~10mg.L.V. urine pH ~8mg.I.V. urine 100 6*5 or below.pH 6.5 or below.
Repeated Blood Donations and Erythropoietin Levels
Authors: Paul Martin Kempen
Journal: JAMA (1989)

To the Editor. —  The recent study of the human erythropoietin response to autologous donation1concluded that the current guidelines for autologous blood banking (hematocrit >0.34) do not allow a significant degree of anemia to develop in patients. Increased levels of erythropoietin and erythropoiesis were not observed, implying that preoperative autologous storage may not increase the total red blood cell mass at the time of surgery.  These findings may be methodological artifacts typical of suboptimal clinical predonation programs. Most patients deposited 3 U or less at three-day intervals over a short period (nine to 12 days). The spontaneous erythropoietic response to sustained phlebotomy-induced anemia requires seven to nine days to initiate and becomes maximal at three weeks, with adequate iron stores.2Phlebotomy is best begun four to five weeks from the date of planned surgery. This maximizes the preoperative period of increased erythropoiesis, within the limits of liquid
Effect of electrical cardioversion on myocardial cells in patients in intensive care
Authors: G Neumayr, P Schratzberger, G Friedrich, H Ganzer, C J Wiedermann
Journal: BMJ (1998)

For about 30 years electrical cardioversion has been routine for converting arrhythmias. 1 Whether the application of shocks in the usual dosage is safe is still controversial as minimal myocardial cell injury cannot be excluded. 2If simultaneous muscle damage occurs the measurement of common cardiac markers, especially creatine kinase and its isoenzyme creatine kinase MB, lacks specificity.We therefore also measured the concentration of cardiac troponin T as this is the most sensitive and specific marker to date.
The Charisma of Subgroups and the Subgroups of CHARISMA
Authors: Marc A. Pfeffer, John A. Jarcho
Journal: New England Journal of Medicine (2006)

Antiplatelet therapy with aspirin, an irreversible inhibitor of platelet cyclooxygenase, has earned its rightful place as a cornerstone of treatment for reducing cardiovascular events in patients with established vascular disease.1,2 This statement is based on consistent results favoring aspirin in a large number of randomized, controlled trials in populations with either acute or long-term disease. Clopidogrel, by inhibiting the adenosine diphosphate P2Y12 receptor, offers a distinctly different mechanism to reduce platelet activation and aggregation. As monotherapy, clopidogrel has been shown to be effective in reducing the risk of vascular events in patients with established vascular disease.3 Even more . . .
New Osteoporosis Treatment
Authors: Rebecca Voelker
Journal: JAMA (1998)

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High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors
Authors: Claudia Cattoglio, Danilo Pellin, Ermanno Rizzi, Giulietta Maruggi, Giorgio Corti, Francesca Miselli, Daniela Sartori, Alessandro Guffanti, Clelia Di Serio, Alessandro Ambrosi, Gianluca De Bellis, Fulvio Mavilio
Journal: Blood (2010)
Left ventricular diastolic function. Doppler echocardiographic changes soon after cardiac transplantation.
Authors: F G StGoar, R Gibbons, I Schnittger, H A Valantine, R L Popp
Journal: Circulation (1990)

In acute cardiac rejection, left ventricular diastolic function is altered, and a restrictive ventricular filling pattern occurs. Doppler echocardiographic indexes of mitral inflow have been proposed as sensitive markers of the rejection process. As rejection progresses, the restrictive ventricular filling pattern is reflected by a shortening of isovolumic relaxation time and mitral valve pressure half-time and by an increase in early transmitral filling velocity. Diastolic function is also compromised in the nonrejecting cardiac transplant recipient during the early postoperative period. This study examined the progression in Doppler-derived mitral filling indexes in 25 recent cardiac transplant recipients who demonstrated no histological evidence of transplant rejection. Isovolumic relaxation time, mitral valve pressure half-time, and early transmitral filling velocity were measured at postoperative weeks 1, 2, 4, and 6 on the day that surveillance right ventricular endomyocardial biopsies were performed. The initial indexes were comparable to previously described restrictive parameters and over the 6-week study period evolved into a nonrestrictive filling pattern. This evolution reflects a progressive improvement in postoperative diastolic function and a decrease in left heart filling pressures. None of the evaluated clinical characteristics, including preoperative pulmonary pressures, total ischemic time of the transplanted heart, cardiopulmonary bypass time, and age of the donor heart, correlated with this process. Given the increasing use of Doppler echocardiography as a means of screening for transplant rejection, it is important to have a thorough understanding of normal postoperative changes in left ventricular diastolic function.
Evaluation of nurse triage in a British accident and emergency department.
Authors: S. George, S. Read, L. Westlake, B. Williams, A. Fraser-Moodie, P. Pritty
Journal: BMJ (1992)

OBJECTIVE--To compare formal nurse triage with an informal prioritisation process for waiting times and patient satisfaction. SETTING--Accident and emergency department of a district general hospital in the midlands in 1990. DESIGN--Patients attending between 8:00 am and 9:00 pm over six weeks were grouped for analysis according to whether triage was operating at time of presentation and by their degree of urgency as assessed retrospectively by an accident and emergency consultant. PATIENTS--5954 patients presenting over six weeks. MAIN OUTCOME MEASURES--Time waited between first attendance in the department and obtaining medical attention, and patient satisfaction measured by questionnaire. RESULTS--Complete data on waiting time were collected on 5037 patients (85%). Only 1213 of the 2515 (48%) patients presenting during the triage period were seen by a triage nurse. Patients in the triage group waited longer than those in the no triage group in all four retrospective priority categories, though differences were significant for only the two most urgent categories (difference in median waiting time 10.5 (95% confidence interval 3.5 to 14) min for category 1 and 8.5 (3 to 12) min for category 2). Responses to the patient satisfaction questionnaire were similar in the two groups except for the question relating to anxiety relating to pain. CONCLUSIONS--This study fails to show the benefits claimed for formal nurse triage. Nurse triage may impose additional delay for patient treatment, particularly among patients needing the most urgent attention.