Metabolic Abnormalities of Lactic Acid in Burkitt-type Lymphoma with Malignant Effusions
Authors: JEROME B. BLOCK
Journal: Annals of Internal Medicine (1966)

Case Studies1 July 1966Metabolic Abnormalities of Lactic Acid in Burkitt-type Lymphoma with Malignant EffusionsJEROME B. BLOCK, M.D., WILLIAM R. BRONSON, M.D., WILLIAM R. BELL, M.D.JEROME B. BLOCK, M.D.Search for more papers by this author, WILLIAM R. BRONSON, M.D.Search for more papers by this author, WILLIAM R. BELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-1-101 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElevations of blood lactic acid rarely are observed in patients with cancer uncomplicated by shock or hypoxia. However, Field, Block, and Rall (1) and Field, Block, Levin, and Rall (2) noted an occasional relationship between extensive leukemia and development of clinical lactic acidosis. They suggested that lactic acid produced by leukemic tissue may be the cause of such a metabolic disorder although leukemic cells are paradoxically characterized by low in vitro rates of glycolysis (2-6), in contrast to most malignant neoplasms (7-10).Recently, a patient with "Burkitt's lymphoma" was admitted to the National Cancer Institute. The initial manifestations of the...References1. FIELDBLOCKRALL MJBDP: Lactic acidosis in acute leukemia (abstract). Clin. Res. 11: 193, 1963. Google Scholar2. FIELDBLOCKLEVINRALL MJBRDP: The significance of elevations of blood lactate in patients with neoplastic and other proliferative disorders. Amer. J. Med. 40: 528, 1966. CrossrefGoogle Scholar3. BECKVALENTINE WSWN: Aerobic carbohydrate metabolism of leukocytes in health and leukemia. Cancer Res. 12: 818, 1952. MedlineGoogle Scholar4. MCKINNEYRUNDLES GRRW: Lactate formation and glyoxalase activity in normal and leukemic human leukocytes in vitro. Cancer Res. 16: 67, 1956. MedlineGoogle Scholar5. BIRDCLEMENTSBECKER RWJACM: The metabolism of leukocytes taken from peripheral blood of leukemic patients. Cancer 4: 1009, 1951. CrossrefMedlineGoogle Scholar6. LUGANOVASEYTS ISIF: Two types of leukocyte metabolism in acute leukemia. Aktual'niye voprosy perelivaniya Krovi, No. 7 p. 122, 1959. Google Scholar7. WARBURGWINDNEGELEIN OFE: The metabolism of tumors in the body. J. Gen. Physiol. 8: 519, 1927. CrossrefMedlineGoogle Scholar8. BUSCH H: An Introduction to the Biochemistry of the Cancer Cell. Academic Press, New York, 1962, pp. 313-352. Google Scholar9. BURK D: A colloquial consideration of the Pasteur and neo-Pasteur effects. Cold Spring Harbor Symposia Quant. Biol. 7: 420, 1939. CrossrefGoogle Scholar10. WARBURG O: Metabolism of Tumors. Smith, New York, 1931. Google Scholar11. FALLONFREIDAVIDSONTRIERBURK HJEJDJSD: Leukocyte preparations from human blood: evaluation of their morphologic and metabolic state. J. Lab. Clin. Med. 59: 779, 1962. MedlineGoogle Scholar12. SEGALBLAIRWYNGAARDEN SAEJB: An enzymatic spectrophotometric method for the determination of pyruvic acid in blood. J. Lab. Clin. Med. 48: 137, 1956. MedlineGoogle Scholar13. HOFFMAN WS: A rapid photo-electric method for the determination of glucose in blood and urine. J. Biol. Chem. 127: 51, 1937. CrossrefGoogle Scholar14. VESELL ES: Localization of lactic acid dehydrogenase activity in serum fractions. Proc. Soc. Exp. Biol. Med. 84: 704, 1953. MedlineGoogle Scholar15. HASTINGSSALVESENSENDROYVAN SLYKE ABHAJDD: Studies of gas and electrolyte equilibria in the blood. IX. The distribution of electrolytes between transudates and serum. J. Gen. Physiol. 8: 701, 1927. CrossrefMedlineGoogle Scholar16. GREENBOLLMANKEITHWAKEFIELD CHJLNMEG: The distribution of electrolytes between serum and transudates. J. Biol. Chem. 91: 203, 1931. CrossrefGoogle Scholar17. GILLIGANVOLKBLUMGART RMCHL: Observations on the chemical and physical relation between blood serum and body fluids. I. The nature of edema fluid and evidence regarding the mechanisms of edema formation. J. Clin. Invest. 13: 365, 1934. CrossrefMedlineGoogle Scholar18. PINNERMOERKE MG: Pleural effusions: laboratory findings and clinical correlation. Amer. Rev. Tuberc. 22: 121, 191. Google Scholar19. O'CONORRAPPAPORTSMITH GTHEB: Childhood lymphoma resembling "Burkitt tumor" in the U. S. Cancer 18: 411, 1965. CrossrefMedlineGoogle Scholar20. DORFMAN RE: Childhood lymphosarcoma in St. Louis, Missouri, clinically and histologically resembling Burkitt's tumor. Ibid., p. 418. Google Scholar21. RECANTLACY LP (editors): Lymphosarcoma in a St. Louis girl clinically and histologically resembling Burkitt's African Lymphoma (Clinicopathologic Conference, Washington University, School of Medicine). Amer. J. Med. 38: 96, 1965. CrossrefMedlineGoogle Scholar22. PRENTICESIRIJOINER TCWEE: Quantitative studies of ascitic fluid circulation with tritium labelled water. Amer. J. Med. 13: 668, 1952. CrossrefMedlineGoogle Scholar23. TYOR M: HSA tagged with I131 in patients with ascites caused by abdominal carcinomatosis and portal cirrhosis: the rates of exchange between the vascular compartment and peritoneal cavity. J. Lab. Clin. Med. 44: 110, 1954. MedlineGoogle Scholar24. KEMPMENDEL AB: How does the Ehrlich ascites tumor obtain its energy for growth? Nature (London) 180: 132, 1957. CrossrefGoogle Scholar25. DEL MONTEROSSI UCB: Glucose supply by the living host and glycolysis of Yoshida ascites heptatoma in vivo. Cancer Res. 23: 363, 1963. MedlineGoogle Scholar26. WATERSHALLSCHWARTZ WCJDWB: Spontaneous lactic acidosis. The nature of the acid-base disturbance and considerations in diagnosis and management. Amer. J. Med. 35: 781, 1963. CrossrefMedlineGoogle Scholar27. ELKINTON JR: Hydrogen ion turnover in health and in renal disease. Ann. Intern. Med. 57: 660, 1962. LinkGoogle Scholar28. JUDGEVAN EYS MAJ: Excretion of D-lactic acid by humans. J. Nutr. 76: 310, 1962. CrossrefMedlineGoogle Scholar29. HANDLER JS: The role of lactic acid in the reduced excretion of uric acid in toxemia of pregnancy. J. Clin. Invest. 39: 1526, 1960. CrossrefMedlineGoogle Scholar30. YUSIROTABERGERHALPERNGUTMAN TFJHLMAB: Effect of sodium lactate infusion or urate clearance in man. Proc. Soc. Exp. Biol. Med. 96: 809, 1957. CrossrefMedlineGoogle Scholar31. ALTSCHULEPERRINHOLLIDAY MDGMPD: Effect of intravenous administration of lactate on blood pyruvate level in man. Proc. Soc. Exp. Biol. Med. 91: 446, 1956. CrossrefMedlineGoogle Scholar32. HUCKABEE WE Abnormal resting blood lactate. II. Lactic acidosis. Amer. J. Med. 30: 840, 1961. CrossrefMedlineGoogle Scholar33. CORICORI CFGT: The carbohydrate metabolism of tumors. I. The free sugar, lactic acid, and glycogen content of malignant tumors. J. Biol. Chem. 64: 11, 1925. CrossrefGoogle Scholar34. KAHLERROBERTSON HWV: Hydrogen ion concentration of normal liver and hepatic tumors. J. Nat. Cancer Inst. 3: 495, 1943. Google Scholar35. GULLINOCLARKEGRANTHAM PSHFH: Interstitial fluid of solid tumors. Cancer Res. 24: 780, 1964. MedlineGoogle Scholar36. O'CONORRABSON GTAS: Herpes-like particles in an American lymphoma: preliminary note. J. Nat. Cancer Inst. 35: 899, 1965. MedlineGoogle Scholar37. PULVERTAFT RJ: Cytology of Burkitt's tumor. Lancet 1: 238, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Medicine Branch, National Cancer Institute, and the Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Jerome B. Block, M.D., Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md. 20014. 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