tbuckley/cabot-search huggingface dataset:
Women in medicine: Doctors of both sexes are seeking balance between life and work
Authors: S F Gray
Journal: BMJ (2004)

During the COVID-19 pandemic, restrictions for visitors and caregivers in healthcare settings and long-term care (LTC) facilities were enacted in the larger context of public health policies that included physical distancing and shelter-in-place orders. Older persons residing in LTC facilities constituted over half of the mortality statistics across Canada during the first wave of the COVID-19 pandemic. Using the poststructuralist work of Agamben, Foucault and Mbembe we conducted a thematic analysis on news reports. The extracts of media stories presented in our paper suggest that the scholarship on (bio)power and necropolitics is central for understanding the ways the COVID-19 crisis reveals the pragmatic priorities—and the ‘health’ and political values—that undergird the moral imagination of the public, including the educated classes of advanced Western democracies. Our critical analysis shows that by isolating individuals who were sick, fragile, and biologically and socially vulnerable, undifferentiated population management policies like social distancing, when piled on the structural weakness of health systems, reproduced inequities and risk for those in need of medical care, advocacy, and social companionship in acute moments of illness, death and grief. Considering the unprecedented deployment of governmental power via public health interventions based on social regulation to protect the population during the crisis—how can we understand so much death and suffering among the most vulnerable?
Thank You to Our 1991 Peer Reviewers
Authors: Elaine S. Williams
Journal: JAMA (1992)

We hereby thank the 2624 peer reviewers who completed<i>JAMA</i>article reviews in 1991 and whose names appear on pages 2089-2095. Due to advances in electronic publishing, we have continued to decrease the median turnaround time for the various steps in the editing and publishing process. In 1991, it took a median of 12 days from receipt to rejection; 82 days from receipt to acceptance; and 163 days from receipt to publication. Of this time, a mean of 26 days was devoted to the peer-review process, with each reviewer handling a mean of 1.9 manuscripts per year. Forty-five percent of manuscripts were sent for outside review, most often to 3 reviewers. Forty-eight percent of manuscripts were rejected without outside review, and 6.8% of manuscripts were accepted without outside review (mostly invited editorials and cover stories). The total acceptance rate for major manuscripts was 18.3%, and the unsolicited manuscript acceptance rate
Potassium Levels After Acute Myocardial Infarction—Reply
Authors: John A. Spertus
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of reactive oxygen and nitrogen species in airway epithelial gene expression.
Authors: L D Martin, T M Krunkosky, J A Voynow, K B Adler
Journal: Environmental Health Perspectives (1998)

The body first encounters deleterious inhaled substances, such as allergens, industrial particles, pollutants, and infectious agents, at the airway epithelium. When this occurs, the epithelium and its resident inflammatory cells respond defensively by increasing production of cytokines, mucus, and reactive oxygen and nitrogen species (ROS/RNS). As inflammation in the airway increases, additional infiltrating cells increase the level of these products. Recent interest has focused on ROS/RNS as potential modulators of the expression of inflammation-associated genes important to the pathogenesis of various respiratory diseases. ROS/RNS appear to play a variety of roles that lead to changes in expression of genes such as interleukin-6 and intercellular adhesion molecule 1. By controlling this regulation, the reactive species can serve as exogenous stimuli, as intercellular signaling molecules, and as modulators of the redox state in epithelial cells. Unraveling the molecular mechanisms affected by ROS/RNS acting in these capacities should aid in the understanding of how stimulated defense mechanisms within the airway can lead to disease.
New Onset of Keratoacanthomas After Vismodegib Treatment for Locally Advanced Basal Cell Carcinomas: A Report of 2 Cases
Authors: Sumaira Aasi, Rona Silkiss, Jean Y. Tang, Ashley Wysong, Andy Liu, Ervin Epstein, Anthony E. Oro, Anne Lynn S. Chang
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
THE CURE OF HAEMORRHOIDS WITHOUT OPERATION
Authors: J. C. Lyth
Journal: BMJ (1921)

MEDICAL JOUTIN 265 almost any conLgenital deformity.In tllis connexion, Hertwig's12 work is of great interest, for be succeeded, by applying chemical solutions to the ova of fish and amphibians, in producing imany deformities, including spina bifida.A pturely chemical and metabolic factor may therefore be at work.Tfhere seems little need niow for the consideration of the discountenanced amniotic band theory as a cause of any suclh defornmlity.Con7clusions.-1.The cause of exomphalos is m-iost likely a defect in tlle developmnent or function of the mesoblastic layer of the abdonminal wall.2. Treatment, to be successful, must be immuediate and consists of open operation.To my chief, Mr. Alex.MacLennan, I am indebted,
An unfortunate (and inappropriate) gastric biopsy
Authors: F. Armelao, E. Tasini
Journal: Endoscopy (2008)

A 66-year-old man presented to the emergency department of our hospital with hematemesis and melena of 10 hours’ duration. On admission, the pulse rate was 81 bpm and blood pressure was 100/50 mm Hg. The hematocrit was 22 %, the platelet count was 103 000/mm3, and the international normalized ratio was 1.19.
Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach.
Authors: S H Safe
Journal: Environmental Health Perspectives (1998)

There is considerable public, regulatory, and scientific concern regarding human exposure to endocrine-disrupting chemicals, which include compounds that directly modulate steroid hormone receptor pathways (estrogens, antiestrogens, androgens, antiandrogens) and aryl hydrocarbon receptor (AhR) agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Based on quantitative structure-activity relationships for both AhR and estrogen receptor (ER) agonists, the relative potency (RP) of individual compounds relative to a standard (e.g. TCDD and 17-beta-estradiol) have been determined for several receptor-mediated responses. Therefore, the TCDD or estrogenic equivalent (TEQ or EQ, respectively) of a mixture is defined as TEQ = sigma[T(i)]xRP(i)or EQ=sigma[E(i)]xRP(i), where T(i) and E(i) are concentrations of individual AhR or ER agonists in any mixture. This approach for risk assessment of endocrine-disrupting mixtures assumes that for each endocrine response pathway, the effects of individual compounds are essentially additive. This paper will critically examine the utility of the TEQ/EQ approach for risk assessment, the validity of the assumptions used for this approach, and the problems associated with comparing low dose exposures to xeno and natural (dietary) endocrine disruptors.
Helicopter Rescues and Deaths Among Trekkers in Nepal
Authors: David R. Shlim
Journal: JAMA (1989)

Trekking in Nepal is a popular recreational activity that involves approximately 45,000 persons each year. The health risk of trekking in Nepal has never been calculated. We retrospectively studied all helicopter evacuations and deaths among trekkers in Nepal between Jan 1, 1984, and June 30, 1987. A total of 148,000 persons obtained trekking permits during that time. Twenty-three persons died and 111 were rescued by helicopter. The risk of dying while trekking was 15 deaths per 100,000 trekking permits. The frequency of helicopter rescue was 75 per 100,000 trekking permits. The most frequent cause of death was trauma (11 persons), followed by illness (eight persons) and acute mountain sickness (three persons). Deaths occurred equally at all altitudes from 1000 m to over 5000 m, although the number of persons at risk at different altitudes could not be calculated. These data suggest that trekking in Nepal is a relatively safe activity, but a decision to embark on a trek in Nepal should be individualized, with an understanding of the problems related to remoteness, altitude, and illness in the absence of medical facilities.
Successful management of a difficult colon stricture with an oblique-view upper scope
Authors: J. Rigaux, V. Poreddy, F. Al-Kawas
Journal: Endoscopy (2009)

We describe the use of an “oblique” view scope in the successful management of an eccentric colonic stricture. A 69-year-old woman with a history of uterine leiomyosarcoma treated by hysterectomy, radiotherapy, and sigmoid resection was referred because of a colon stricture. A recent positron emission tomography (PET) scan showed an area of abnormal uptake in the descending colon. Colonoscopy was not successful in traversing a stricture in the left colon. The patient was referred for a repeat attempt. During our examination, it was not possible to pass a pediatric colonoscope or an upper endoscope through a stricture located 35 cm from the anal verge ([Fig. 1]). Attempts to pass a biliary guide wire with a hydrophilic tip using a sphincterotome were also unsuccessful. Therefore, a prototype upper scope with an oblique-viewing angle (EG-3670QK, Pentax Precision Instruments, Orangeburg, New York, USA) was used to visualize the stricture “en face.” In addition, the elevator that was available allowed manipulation of the sphincterotome and wire to give access beyond the stricture ([Fig. 2]). The stricture was dilated with balloons. Following dilation, a pediatric colonoscope was passed, allowing full examination and biopsy of the stricture area. Pathological findings were consistent with a radiation stricture.
High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-β and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response
Authors: Marc Remke, Stefan Pfister, Corinne Kox, Grischa Toedt, Natalia Becker, Axel Benner, Wiebke Werft, Stephen Breit, Shuangyou Liu, Felix Engel, Andrea Wittmann, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Wolf-Dieter Ludwig, Claus R. Bartram, Bernhard Radlwimmer, Martina U. Muckenthaler, Peter Lichter, Andreas E. Kulozik
Journal: Blood (2009)
Efficient and stable gene transfer of growth factors into chondrogenic cells and primary articular chondrocytes using a VSV.G pseudotyped retroviral vector
Authors: Stephan Vogt, Peter Ueblacker, Christopher Geis, Bettina Wagner, Gabriele Wexel, Thomas Tischer, Achim Krüger, Christian Plank, Martina Anton, Vladimir Martinek, Andreas B. Imhoff, Bernd Gansbacher
Journal: Biomaterials (2008)
Children's respiratory morbidity prevalence in relation to air pollution in four Chinese cities.
Authors: Junfeng Jim Zhang, Wei Hu, Fusheng Wei, Guoping Wu, Leo R Korn, Robert S Chapman
Journal: Environmental Health Perspectives (2002)

We examined respiratory health effects of long-term exposure to ambient air pollution in 7,621 schoolchildren residing in eight districts of four Chinese cities. The four cities exhibited wide between-city and within-city gradients in ambient levels of four size fractions of particulate matter [less than or equal to 2.5 micro m in aerodynamic diameter (PM(2.5)), between 2.5 and 10 micro m (PM(10-2.5)), less than or equal to 10 micro m (PM(10)), and total suspended particulates (TSP)] and two gaseous pollutants (SO(2) and NO(x)). Informed consent and written responses to questionnaires about children's personal, residential, and family information, as well as their health histories and status, were obtained with the help of the parents and the school personnel. We used a two-stage regression approach in data analyses. In the first-stage logistic regressions, we obtained logits of district-specific prevalence of wheeze, asthma, bronchitis, hospitalization for respiratory diseases, persistent cough, and persistent phlegm, adjusted for covariates representing personal, household, and family parameters. Some of these covariates were found to be risk factors of children's respiratory health, including being younger in the study group, being male, having been breast-fed, sharing bedrooms, sharing beds, room being smoky during cooking, eye irritation during cooking, parental smoking, and a history of parental asthma. In several of the second-stage variance-weighted linear regressions, we examined associations between district-specific adjusted prevalence rates and district-specific ambient levels of each pollutant. We found positive associations between morbidity prevalence and outdoor levels of PM of all size fractions, but the association appeared to be stronger for coarse particles (PM(10-2.5)). The results also present some evidence that ambient levels of NO(x) and SO(2) were positively associated with children's respiratory symptoms, but the evidence for these two gaseous pollutants appeared to be weaker than that for the PM.
Nephrostomy Tube or &amp;lsquo;JJ&amp;rsquo; Ureteric Stent in Ureteric Obstruction: Assessment of Patient Perspectives Using Quality&amp;ndash;of&amp;ndash;Life Survey and Utility Analysis
Authors: H.B. Joshi, S. Adams, O.O. Obadeyi, P.N. Rao
Journal: European Urology (2001)
Abstract 3118: Chemokine-targeted colorectal cancer: improved models of human primary tumor formation, liver metastasis and chemoresistance
Authors: Huanhuan Joyce Chen, Jian Sun, Harry Hou, Winfried Edelmann, Xiling Shen, Steven M. Lipkin
Journal: Cancer Research (2014)

Abstract Current human colorectal cancer (CRC) orthotopic xenograft models require surgery and do not readily progress to form tumors in liver, the most common site for metastasis. We developed cell and patient-derived xenograft models that use chemokine-targeting to recapitulate the vast majority of recurrent human somatic CRC mutations as primary gastrointestinal (GI) tumors in mice without requiring surgery. Importantly, we incorporate early-stage mouse blastocyst microinjection techniques to extend this approach and demonstrate that it can also model primary human CRCs in immunoproficient mouse hosts. Next, we show that primary GI tumors can inducibly metastasize to liver. Finally, we use this system to demonstrate that human CRC liver metastases in vivo are more chemoresistant than paired sub-cutaneous xenografts. Overall, we anticipate that this resource can help improve our mechanistic understanding of human primary CRC growth, progression to liver metastasis and potentially provide a more physiological model than sub-cutaneous xenograft for pre-clinical drug discovery. Citation Format: Huanhuan Joyce Chen, Jian Sun, Harry Hou, Winfried Edelmann, Xiling Shen, Steven M. Lipkin. Chemokine-targeted colorectal cancer: improved models of human primary tumor formation, liver metastasis and chemoresistance. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3118. doi:10.1158/1538-7445.AM2014-3118
National director calls for five point plan on care of older people
Authors: Lynn Eaton
Journal: BMJ (2007)

The Department of Health needs a five point plan to improve healthcare services for older people, says England's national clinical director for older people, Ian Philp. 

Early intervention, management of long term conditions, early supported discharge, acute care in hospital when needed, and health and social care agencies working in partnership are all keys to the success of caring for an ageing population, he said. 

“This is already happening in some areas,” said Professor Philps, “but it needs to happen across the country.” 

His report cites examples of delivering care in innovative ways that he …
What happened to evidence in NICE guidance on heart failure?
Authors: J. Robson
Journal: BMJ (2003)

EDITOR–Recent guidelines from the National Institute for Clinical Excellence (NICE) on heart failure recommend measuring natriuretic peptide concentration in patients with suspected heart failure, in addition to electrocardiography to exclude heart failure.1 2 However, normal results on electrocardiography and chest radiography make heart failure highly unlikely.

Low concentrations of natriuretic peptides also …
The Medical Gold Brick of Chicago.
Authors: G. Frank Lydston
Journal: JAMA (1904)

Chicago, July 2, 1904. <h3>To the Editor:</h3> —A worthy gentleman of philanthropic proclivities, a promoter who is alive to the interests of humanity —which is "I," writ large—has discovered that Chicago is suffering from a lack of hospital accommodations. Incidentally he has discovered that there are a few persons who have escaped the net of the hospital grafter and are still foolish enough to employ physicians and to pay them for their services. Bent on remedying this deplorable state of affairs, he is now in Chicago for the purpose of organizing a "co-operative hospital," run on the principle of that much-to-be-anathematized institution, the London Medical Club. The members of the proposed co-operative hospital are to pay a yearly "membership" fee, and the medical staff is to be "paid for its services." The principal alleged<i>raison d'etre</i>for the new scheme is the need of providing accommodations for those "too poor
A Fellow at the Free
Authors: R. Smallwood
Journal: Gut (1978)

I had heard that the Royal Free was unlike any hospital I had ever seen, and yet I was unprepared.I walked up and down Gray's Inn Road three times before I spotted the entrance, and still I had to find the department of medicine.Over the next two years I was to direct many people to the department, and I do not think anybody made it at first attempt.Diagonally across the front square, up one and a half flights of steps and out onto the first roof, across a trail of duck-boards to a fire escape, up the fire escape to the second roof and there you were, looking at a wooden hut with a little sign saying Department of Medicine.Simple, really.I was finally ushered into Prof.'s office, and a white coated figure leapt up from her chair, and came round the large desk with hand outstretched.'Ah, Smallwood, my boy, nice to see you.How is . ..' and she asked after one or two Australian friends.'Have you found anywhere to live?No? Well, first things first.Come back when you have, and then we will see about you.Hm? Hm?' And she was out the door and gone.So that was Sheila Sherlock.
Probabilities of Eventually Developing or Dying of Cancer--United States, 1985
Authors: H. Seidman, M. H. Mushinski, S. K. Gelb, E. Silverberg
Journal: CA A Cancer Journal for Clinicians (1985)

cause of increased interest in thesesites and the changes in their incidence and mor tality rates that have taken place over the years.The probabilities are presented sep arately by sex for whites and for blacks.The method used for calculating the probabilities is the same as the one de
Bodies Willed to Science
Authors: Joseph W. Miller
Journal: JAMA (1962)

<h3>To the Editor:—</h3> I got the message. When the passing bell will toll for me, my body will go to the department of anatomy of my beloved alma mater. Your editorial of June 9, "To Him for Whom the Passing-Bell Next Tolls" (<b>180</b>:830), caused me to make this decision. The upkeep of graves is costly for the family. A buried body is of no use to anyone. It occupies valuable property which could serve better purposes. We all know death is inevitable but why should we be reminded of it every time we pass a cemetery. Bodies willed to medical schools will be useful not only in the teaching of basic anatomy, but also in atomic research, and in the acquisition of greater surgical skill and proficiency in the delicate surgery of the heart, brain, and eye and inner ear.
New York doctor charged with fraud in surgery on mentally ill patients
Authors: F. Charatan
Journal: BMJ (2002)

Dr Shaul Debbi, 48, a New York City ophthalmologist, has been charged with performing unnecessary cataract surgery on mentally ill residents of Leben Home in Queens, New York.

An FBI complaint, unsealed in federal court, stated that Dr Debbi conducted nearly 50 eye operations on more than 30 Leben residents in 1999 and 2000. The procedures cost the government …
Moynihan's Disease? the Diagnosis of Duodenal Ulcer
Authors: Howard M. Spiro
Journal: New England Journal of Medicine (1974)

THE clinical diagnosis of duodenal ulcer seems to have been revolutionized by advances in technology, particularly by the development of the fiber-endoscope during the past few years. Yet many questions still need to be asked. In many ways, to consider the clinical diagnosis of duodenal ulcer is to wander in the wiles of epistemology. How do we know? What do we know? Is the matter of duodenal ulcer and its pain simply solipsistic, pain being all that counts, or must we see the ulcer to know that it is there? Is there a different outlook for the patient with duodenal-ulcer . . .