tbuckley/cabot-search huggingface dataset:
Adverse Events Associated With Mohs Micrographic Surgery
Authors: Murad Alam, Omer Ibrahim, Michael Nodzenski, John M. Strasswimmer, Shang I. Brian Jiang, Joel L. Cohen, Brian J. Albano, Priya Batra, Ramona Behshad, Anthony V. Benedetto, C. Stanley Chan, Suneel Chilukuri, Courtney Crocker, Hillary W. Crystal, Anir Dhir, Victoria A. Faulconer, Leonard H. Goldberg, Chandra Goodman, Steven S. Greenbaum, Elizabeth K. Hale, C. William Hanke, George J. Hruza, Laurie Jacobson, Jason Jones, Arash Kimyai-Asadi, David Kouba, James Lahti, Kristi Macias, Stanley J. Miller, Edward Monk, Tri H. Nguyen, Gagik Oganesyan, Michelle Pennie, Katherine Pontius, William Posten, Jennifer L. Reichel, Thomas E. Rohrer, James A. Rooney, Hien T. Tran, Emily Poon, Diana Bolotin, Meghan Dubina, Natalie Pace, Natalie Kim, Wareeporn Disphanurat, Ummul Kathawalla, Rohit Kakar, Dennis P. West, Emir Veledar, Simon Yoo
Journal: JAMA Dermatology (2013)

Detailed information regarding perioperative risk and adverse events associated with Mohs micrographic surgery (MMS) can guide clinical management. Much of the data regarding complications of MMS are anecdotal or report findings from single centers or single events.To quantify adverse events associated with MMS and detect differences relevant to safety.Multicenter prospective inception cohort study of 21 private and 2 institutional US ambulatory referral centers for MMS. Participants were a consecutive sample of patients presenting with MMS for 35 weeks at each center, with staggered start times.Mohs micrographic surgery. MAIN OUTCOMES AND MEASURES Intraoperative and postoperative minor and serious adverse events.Among 20 821 MMS procedures, 149 adverse events (0.72%), including 4 serious events (0.02%), and no deaths were reported. Common adverse events reported were infections (61.1%), dehiscence and partial or full necrosis (20.1%), and bleeding and hematoma (15.4%). Most bleeding and wound-healing complications occurred in patients receiving anticoagulation therapy. Use of some antiseptics and antibiotics and sterile gloves during MMS were associated with modest reduction of risk for adverse events.Mohs micrographic surgery is safe, with a very low rate of adverse events, an exceedingly low rate of serious adverse events, and an undetectable mortality rate. Common complications include infections, followed by impaired wound healing and bleeding. Bleeding and wound-healing issues are often associated with preexisting anticoagulation therapy, which is nonetheless managed safely during MMS. We are not certain whether the small effects seen with the use of sterile gloves and antiseptics and antibiotics are clinically significant and whether wide-scale practice changes would be cost-effective given the small risk reductions.
Stressing the ubiquitin-proteasome system
Authors: N. P. Dantuma, K. Lindsten
Journal: Cardiovascular Research (2009)

Unfolded and misfolded proteins are inherently toxic to cells and have to be quickly and efficiently eliminated before they intoxicate the intracellular environment. This is of particular importance during proteotoxic stress when, as a consequence of intrinsic or extrinsic factors, the levels of misfolded proteins are transiently or persistently elevated. To meet this demand, metazoan cells have developed specific protein quality control mechanisms that allow the identification and proper handling of non-native proteins. An important defence mechanism is the specific destruction of these proteins by the ubiquitin-proteasome system (UPS). A number of studies have shown that various proteotoxic stress conditions can cause functional impairment of the UPS resulting in cellular dysfunction and apoptosis. In this review, we will summarize our current understanding of proteotoxic stress-induced dysfunction of the UPS and some of its implications for human pathologies.
Rooting the Eukaryotic Tree with Mitochondrial and Bacterial Proteins
Authors: R. Derelle, B. F. Lang
Journal: Molecular Biology and Evolution (2011)

By exploiting the large body of genome data and the considerable progress in phylogenetic methodology, recent phylogenomic studies have provided new insights into the relationships among major eukaryotic groups. However, confident placement of the eukaryotic root remains a major challenge. This is due to the large evolutionary distance separating eukaryotes from their closest relatives, the Archaea, implying a weak phylogenetic signal and strong long-branch attraction artifacts. Here, we apply a new approach to the rooting of the eukaryotic tree by using a subset of genomic information with more recent evolutionary origin—mitochondrial sequences, whose closest relatives are α-Proteobacteria. For this, we identified and assembled a data set of 42 mitochondrial proteins (mainly encoded by the nuclear genome) and performed Bayesian and maximum likelihood analyses. Taxon sampling includes the recently sequenced Thecamonas trahens, a member of the phylogenetically elusive Apusozoa. This data set confirms the relationships of several eukaryotic supergroups seen before and places the eukaryotic root between the monophyletic “unikonts” and “bikonts.” We further show that T. trahens branches sister to Opisthokonta with significant statistical support and question the bikont/excavate affiliation of Malawimonas species. The mitochondrial data set developed here (to be expanded in the future) constitutes a unique alternative means in resolving deep eukaryotic relationships.
ASSESSMENT OF THE INCIDENCE AND CORRELATES OF UPWARD CREEP DURING GATED SPECT EXERCISE THALLIUM CARDIAC IMAGING.
Authors: T. D. Payne, J. J. Pippin, J. J. Nemec, A. D. Ross, C. J. Branstetter, S. M. Devers, C. M. Carr, S. J. Durham
Journal: Clinical Nuclear Medicine (1997)

Payne, T. D.; Pippin, J. J.; Nemec, J. J.; Ross, A. D.; Branstetter, C. J.; Devers, S. M.; Carr, C. M.; Durham, S. J. Author Information
The Prevalence of Coffee Drinking Among Hospitalized and Population-Based Control Groups
Authors: Debra T. Silverman, Robert N. Hoover, G. Marie Swanson, Patricia Hartge
Journal: JAMA (1983)

Data on coffee-drinking habits obtained from a case-control study conducted in Detroit were used to compare the proportions of coffee drinkers in a hospital and a population control series. The comparison was based on interviews with 262 hospitalized controls and 427 population controls. The overall proportion of coffee drinkers in the total hospital control group was similar to that in the population control group. However, the proportion of moderate-to-heavy coffee drinkers among controls hospitalized for conditions that may have caused them to alter their diet (eg, gastrointestinal disorders and cardiovascular disease) was lower than that among population controls. In contrast, the proportion of moderate-to-heavy coffee drinkers among controls hospitalized for conditions that probably did not cause a change in diet (eg, fractures) was almost identical to that among population controls. These results suggest that, in hospital-based case-control studies of the effects of coffee consumption, it would be prudent to restrict the referent group to those patients hospitalized for conditions that probably did not cause a change in diet. The magnitude of bias resulting from failure to exclude controls hospitalized for diet-altering conditions will depend on two factors that may vary between studies: (1) the distribution of diet-altering conditions among the hospital controls, and (2) the relationship of these diseases to coffee consumption.
Jaundice Occurring in a Patient Treated with Chlorothiazide
Authors: A. L. Drerup, W. A. Alexander, George D. Lumb, A. J. Cummins, G. M. Clark
Journal: New England Journal of Medicine (1958)

THE recently demonstrated effectiveness of chlorothiazide as a diuretic and antihypertensive agent has led to its increasing use in the treatment of congestive cardiac failure and hypertension. For this reason, the occurrence of jaundice in a patient taking this compound is of interest.Case ReportO.G., a 62-year-old colored woman, was known to have had diabetes mellitus since 1948 that had required hospital care for regulation on several occasions. In addition, treatment for congestive cardiac failure secondary to arteriosclerotic heart disease had been required. At previous examinations, an enlarged liver had been palpated, and xanthelasma over both eyelids had been . . .
Soluble CD40 Ligand in Morbidly Obese Patients
Authors: Juan A. Baena-Fustegueras, Eva Pardina, Eva Balada, Roser Ferrer, Roberto Catalán, Joaquín Rivero, Isidre Casals, Albert Lecube, Jose M. Fort, Víctor Vargas, Julia Peinado-Onsurbe
Journal: JAMA Surgery (2013)

<h3>Importance</h3>In recent years, the CD40/CD40L system has been implicated in the pathophysiology of severe chronic inflammatory diseases. Recently, obesity has been described as a low chronic inflammatory disease, so this system could also be involved in the inflammatory process.<h3>Objective</h3>To study soluble CD40 ligand (sCD40L) and other factors implicated in coagulation (plasminogen activator inhibitor 1, antithrombin III, and fibrinogen) and inflammation (C-reactive protein) in patients with morbid obesity and different body mass indexes (BMIs) (calculated as weight in kilograms divided by height in meters squared), before and after weight loss induced by bariatric surgery.<h3>Design</h3>Plasma samples were obtained before and after a bariatric surgery intervention. Several inflammatory markers were then studied (sCD40L, plasminogen activator inhibitor 1, antithrombin III, and C-reactive protein). The values obtained were compared with a control group of nonobese persons.<h3>Participants</h3>Thirty-four morbidly obese patients undergoing gastric bypass surgery and 22 normal-weight controls matched for age and sex.<h3>Interventions</h3>A Roux-en-Y gastric bypass was performed in morbidly obese patients.<h3>Main Outcome Measures</h3>Levels of sCD40L, plasminogen activator inhibitor 1, antithrombin III, fibrinogen, and C-reactive protein 12 months after bariatric surgery.<h3>Results</h3>Obese men showed a tendency for decreased plasma sCD40L levels 1 year after surgery (mean [SEM], 246.5 [70.4] pg/mL before vs 82.2 [23.2] pg/mL after surgery; P &lt; .05), whereas there were not any significant changes in obese women (285.9 [67.5] pg/mL before vs 287.0 [56.9] pg/mL after surgery). Levels of the other markers studied decreased significantly with weight loss in both sexes. However, all other studied markers tend to have higher concentrations in patients with higher BMIs, except for sCD40L, which tended to have lower concentrations in patients with BMIs higher than 55. The decreases with weight loss were lower with higher BMIs for all measurements, except for antithrombin III.<h3>Conclusions and Relevance</h3>Increased BMI, but not sex, influences recovery to normal levels for the markers studied, possibly indicating a worse prognosis.
Surgical Correction of Funnel Chest-Reply
Authors: Albert Fink
Journal: JAMA (1962)

<h3>To the Editor:—</h3> The attitude expressed by Dr. Lester in his letter serves to exemplify the existing controversy on the consequences of pectus excavatum. We are disappointed that in view of Dr. Lester's passion for accuracy, he was not more precise in paraphrasing the editorial. Also, our curiosity was aroused (and piqued) as to the reasons for his completely unsupported claims that the attitude of our article and the editorial were based on "inaccurate" and "irrelevant" studies. The main issue he raises concerns the problem of exercise capacity. We disagree with Dr. Lester that exercise intolerance is "the outstanding feature in funnel chest." Careful questioning of our cases revealed that only 2 of the Group I patients had noteworthy limitation of activity, and in both subjects it could be related to factors beside the thoracic defect. Moreover, Dr. Lester is seemingly unaware of the large cardiac catheterization study by Fabricius
Comparative Survival of Transplanted Heart and Skin in Inbred Rats
Authors: JAN S. FREEMAN, KEITH REEMTSMA, DAVID STEINMULLER
Journal: Circulation (1970)

Skin, kidney, and heart allografts are all rejected acutely by inbred rats when the donor and recipient strains are incompatible at the Ag-B or major rat histocompatibility locus. In contrast, in Ag-B compatible strain combinations, kidney allografts usually survive indefinitely even though skin allografts are still rejected acutely. Unfortunately, matching at major loci may not insure the prolonged survival of organ as opposed to skin allografts in general because heart allografts in the Ag-B compatible Fischer to Lewis strain combination are rejected acutely, like skin. Evidence that donor pretreatment of rat heart allografts with leukocidal agents can prolong graft survival suggests that the degree of immunogenicity of grafts may be related in part to their leukocyte content.
CALCINOSIS CIRCUMSCRIPTA PRESENTING AS VARICOSE ULCERATION.
Authors: STANLEY RIVLIN
Journal: British Journal of Dermatology (1958)

Journal Article CALCINOSIS CIRCUMSCRIPTA PRESENTING AS VARICOSE ULCERATION. Get access STANLEY RIVLIN, M.R.C.S. STANLEY RIVLIN, M.R.C.S. Surgeon to the London Varicose Clinic, S.W.11 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 70, Issue 3, 1 March 1958, Pages 107–109, https://doi.org/10.1111/j.1365-2133.1958.tb13299.x Published: 01 March 1958
Cardiomyopathy of pregnancy.
Authors: C. A. Ross
Journal: BMJ (1968)

judged by this trial, the 500 pg.dosage pro- vided a reasonable safety margin to allow for irregular taking of therapy.A similar trial on pregnant patients with established folate deficiency, administering either 500 fg.or 5 mg.folic acid three times daily, also showed no significant difference in response between the two dosage groups.Nevertheless, the need for continued clinical and laboratory supervision needs emphasis, since, even when 15 mg.folic acid is given daily, a small proportion of patients fail to show a satisfactory response.Could we also draw attention to a minor error in your article ?It is stated that oral preparations of folic acid alone in the microgramme range are generally not available.A tablet of folic acid B.P. 100 jug.
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.
Authors: S Han, B Zheng, J Dal Porto, G Kelsoe
Journal: The Journal of Experimental Medicine (1995)

Germinal centers (GCs) are the sites of antigen-driven V(D)J gene hypermutation and selection necessary for the generation of high affinity memory B lymphocytes. Despite the antigen dependence of this reaction, injection of soluble antigen during an established primary immune response induces massive apoptotic death in GC B cells, but not in clonally related populations of nonfollicular B lymphoblasts and plasmacytes. Cell death in GCs occurs predominantly among light zone centrocytes, is antigen specific, and peaks within 4-8 h after injection. Antigen-induced programmed death does not involve cellular interactions mediated by CD40 ligand (CD40L) or Fas; disruption of GCs by antibody specific for CD40L was not driven by apoptosis and C57BL/6.lpr mice, though unable to express the Fas death trigger, remained fully susceptible to soluble antigen. Single injections of antigen did not significantly decrease GC numbers or average size, but repeated injections during an 18-h period resulted in fewer and substantially smaller GCs. As cell loss appeared most extensive in the light zone, decreased GC cellularity after prolonged exposure to soluble antigen implies that the Ig- centroblasts of the dark zone may require replenishment from light zone cells that have survived antigenic selection. GC cell death is avidity-dependent; oligovalent antigen induced relatively little apoptosis and GC B cells that survived long exposures to multivalent antigen expressed atypical VDJ rearrangements unlikely to encode high affinity antibody. Antigen-induced apoptotic death in GCs may represent a mechanism for the peripheral deletion of autoreactive B cell mutants much as the combinatorial repertoire of immature B lymphocytes is censored in the bone marrow.
Survivors of Cancer in Childhood
Authors: FREDERICK P. LI
Journal: Annals of Internal Medicine (1976)

Late effects of childhood cancer in 142 patients, presently aged 18 years and older, were examined with a medical record review and questionnaire survey. Seventy-four patients (52%) had major defects in treated organs, while 17 (12%) developed second primary neoplasms (10 malignancies and 7 benign tumors). Despite these disorders, most patients had fully active lives. Eighty-six (61%) had attended college, and many were employed as professionals or managers. Seventy-five (53%) were married; 46 had progeny. Disabling psychological illness attributed to cancer in childhood was uncommon. These findings indicate the potential for high quality of extended life for most survivors of childhood cancer. Comprehensive long-term care of these patients may further reduce adverse physiologic and psychosocial sequelae.
Breast cancer trials--a new initiative.
Authors: M Spittle
Journal: BMJ (1981)

<h3>Abstract</h3> <h3>Objective</h3> To examine the association between dipeptidyl peptidase-4 inhibitors and gallbladder or biliary diseases. <h3>Design</h3> Systematic review and pairwise and network meta-analysis. <h3>Data sources</h3> PubMed, EMBASE, Web of Science, and CENTRAL from inception until 31 July 2021. <h3>Eligibility criteria</h3> Randomised controlled trials of adult patients with type 2 diabetes who received dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, and sodium-glucose cotransporter-2 inhibitors compared with placebo or other antidiabetes drugs. <h3>Main outcome measures</h3> Composite of gallbladder or biliary diseases, cholecystitis, cholelithiasis, and biliary diseases. <h3>Data extraction and data synthesis</h3> Two reviewers independently extracted the data and assessed the quality of the studies. The quality of the evidence for each outcome was assessed using the Grading of Recommendations, Assessment, Development and Evaluations framework (GRADE) approach. The meta-analysis used pooled odds ratios and 95% confidence intervals. <h3>Results</h3> A total of 82 randomised controlled trials with 104 833 participants were included in the pairwise meta-analysis. Compared with placebo or non-incretin drugs, dipeptidyl peptidase-4 inhibitors were significantly associated with an increased risk of the composite of gallbladder or biliary diseases (odds ratio 1.22 (95%confidence interval 1.04 to 1.43); risk difference 11 (2 to 21) more events per 10 000 person years) and cholecystitis (odds ratio 1.43 (1.14 to 1.79); risk difference 15 (5 to 27) more events per 10 000 person years) but not with the risk of cholelithiasis and biliary diseases. The associations tended to be observed in patients with a longer duration of dipeptidyl peptidase-4 inhibitor treatment. In the network meta-analysis of 184 trials, dipeptidyl peptidase-4 inhibitors increased the risk of the composite of gallbladder or biliary diseases and cholecystitis compared with sodium-glucose cotransporter-2 inhibitors but not compared with glucagon-like peptide-1 receptor agonists. <h3>Conclusions</h3> Dipeptidyl peptidase-4 inhibitors increased the risk of cholecystitis in randomised controlled trials, especially with a longer treatment duration, which requires more attention from physicians in clinical practice. <h3>Systematic review registration</h3> PROSPERO CRD42021271647.
Tuberculosis Screening and Indications for Preventive Therapy-Reply
Authors: Stephen S. Lefrak
Journal: JAMA (1992)

<h3>In Reply.</h3> —Dr Carlen's letter quite correctly discusses the indications for isoniazid prophylaxis in close contacts of children with tuberculosis whose initial tuberculin tests are negative. The article to which he is referring was discussing the interpretation of tuberculin testing in elderly patients and not the indications for isoniazid prophylaxis, especially in children. I certainly agree that children, particularly infants, should receive isoniazid prophylaxis if they are close contacts of patients with tuberculosis, regardless of their initial tuberculin test results. Although one could argue this point for adults, it seems reasonable to begin isoniazid prophylaxis initially and repeat the tuberculin test in 4 to 6 weeks and judge continuation of treatment at that point.
Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity
Authors: Julia D Suerth, Tobias Maetzig, Martijn H Brugman, Niels Heinz, Jens-Uwe Appelt, Kerstin B Kaufmann, Manfred Schmidt, Manuel Grez, Ute Modlich, Christopher Baum, Axel Schambach
Journal: Molecular Therapy (2012)

Comparative integrome analyses have highlighted alpharetroviral vectors with a relatively neutral, and thus favorable, integration spectrum. However, previous studies used alpharetroviral vectors harboring viral coding sequences and intact long-terminal repeats (LTRs). We recently developed self-inactivating (SIN) alpharetroviral vectors with an advanced split-packaging design. In a murine bone marrow (BM) transplantation model we now compared alpharetroviral, gammaretroviral, and lentiviral SIN vectors and showed that all vectors transduced hematopoietic stem cells (HSCs), leading to comparable, sustained multilineage transgene expression in primary and secondary transplanted mice. Alpharetroviral integrations were decreased near transcription start sites, CpG islands, and potential cancer genes compared with gammaretroviral, and decreased in genes compared with lentiviral integrations. Analyzing the transcriptome and intragenic integrations in engrafting cells, we observed stronger correlations between in-gene integration targeting and transcriptional activity for gammaretroviral and lentiviral vectors than for alpharetroviral vectors. Importantly, the relatively "extragenic" alpharetroviral integration pattern still supported long-term transgene expression upon serial transplantation. Furthermore, sensitive genotoxicity studies revealed a decreased immortalization incidence compared with gammaretroviral and lentiviral SIN vectors. We conclude that alpharetroviral SIN vectors have a favorable integration pattern which lowers the risk of insertional mutagenesis while supporting long-term transgene expression in the progeny of transplanted HSCs.
The Autonomous Heart in Diabetic Autonomic Neuropathy
Authors: Samuel Vaisrub
Journal: JAMA (1976)

When autonomic neuropathy involving the cardiovascular system of a diabetic patient is manifested by postural hypotension, it is easily recognizable. Much less obvious and less well known is the effect of the neuropathy on the regulation of the heart rate. That this effect may be striking could be surmised from animal experiments<sup>1</sup>and, more important, from the unique model of cardiac denervation provided by cardiac transplantation in the human. Griepp et al<sup>2</sup>demonstrated that the heart rate increased only slightly during the initial phase of exercise in patients with transplanted hearts. A pronounced increase occurred later in exercise, presumably when catecholamines reached the heart after they had been released into the circulation from extracardiac sites. In some patients, the heart rate barely changed during maneuvers designed to stimulate or inhibit the autonomic nervous system. Lloyd-Mostyn and Watkins<sup>3</sup>recently reported a near-total nonsurgical cardiac denervation in a patient
Effect of rush immunotherapy on airway inflammation and airway hyperresponsiveness after bronchoprovocation with allergen in asthma☆☆☆★
Authors: Yasurou Kohno, Kenji Minoguchi, Naruhito Oda, Takuya Yokoe, Naomi Yamashita, Tsuyoshi Sakane, Mitsuru Adachi
Journal: Journal of Allergy and Clinical Immunology (1998)