tbuckley/cabot-search huggingface dataset:
Childhood cancer and agricultural pesticide use: an ecologic study in California.
Authors: Peggy Reynolds, Julie Von Behren, Robert B Gunier, Debbie E Goldberg, Andrew Hertz, Martha E Harnly
Journal: Environmental Health Perspectives (2002)

We analyzed population-based childhood cancer incidence rates throughout California in relation to agricultural pesticide use. During 1988-1994, a total of 7,143 cases of invasive cancer were diagnosed among children under 15 years of age in California. Building on the availability of high-quality population-based cancer incidence information from the California Cancer Registry, population data from the U.S. Census, and uniquely comprehensive agricultural pesticide use information from California's Department of Pesticide Regulation, we used a geographic information system to assign summary population, exposure, and outcome attributes at the block group level. We used Poisson regression to estimate rate ratios (RRs) by pesticide use density adjusted for race/ethnicity, age, and sex for all types of childhood cancer combined and separately for the leukemias and central nervous system cancers. We generally found no association between pesticide use density and childhood cancer incidence rates. The RR for all cancers was 0.95 [95% confidence interval (CI), 0.80-1.13] for block groups in the 90th percentile and above for use of pesticides classified as probable carcinogens, compared to the block groups with use of < 1 lb/mi(2). The RRs were similar for leukemia and central nervous system cancers. Childhood leukemia rates were significantly elevated (RR = 1.48; 95% CI, 1.03-2.13) in block groups with the highest use of propargite, although we saw no dose-response trend with increasing exposure categories. Results were unchanged by further adjustment for socioeconomic status and urbanization.
Trefoil peptides and the gut.
Authors: N A Wright
Journal: Gut (1993)

Trefoil peptides and the gutA new group ofpeptides has recently come to the attention of gastroenterologists: the trefoil peptides are a highly con- served group of molecules that, in the human at least, are widely distributed in gastrointestinal tissues and their primary role in man is highly likely to be in the gastrointestinal
Confidentiality in Medicine
Authors: J. Taylor
Journal: BMJ (1974)

ceivably be playing a part in the aetiology of other disease entities,9 and halogenated salicylanilides and related compounds may not be the only drugs retained in this manner.'0Dr. R. H. Champion, in the article "Diseases of the Skin: Drug Therapy of Urticaria" (22 December 1973, p. 730) states that "antihistamine drugs may, if necessary, be continued for months or years with safety."How can he be sure of this?How can we be certain that any of the photosensitizing drugs which cover a wide therapeutic range and include several anti- histamines are not retained in the dermis for long periods, eventually playing a part in the production of actinic reticuloid in sus- ceptible subjects?Promethazine, an anti- histamine, and chlorpromazine, a tran- quillizer, two phenothiazine derivatives, may cause persistent photodermatitis which depends upon concomitant oral administration and external application."'3The active photocontact sensitizers cause multiple cross- sensitivities'4 and it is conceivable that one or several photosensitizing drugs retained in the dermis might be immunologically activated by an external powerful sensitizer such as fenticlor, leading to actinic reticu- loid.-Iam, etc.,
Is hypertension an autoimmune disease?
Authors: Jordan S. Pober
Journal: Journal of Clinical Investigation (2014)

T cells are required for significant blood pressure elevation in mouse models of hypertension. Recent evidence suggests that the treatments that raise blood pressure in these animal models also cause oxidation within DCs, resulting in formation of isoketal adducts of self-proteins, which activate antigen-presenting functions of these cells and serve as a source of modified self-antigens. T cells specific for these modified self-antigens then produce cytokines that promote blood pressure elevation, consistent with the idea that hypertension is an autoimmune response to altered self. Here, I will review the new evidence for this idea put forth by Kirabo and colleagues in this issue of the JCI, identify a number of as yet unanswered questions, and discuss some of the therapeutic implications.
Traumatic Rupture of the Gallbladder With Massive Biliary Ascites
Authors: Denis J. Frank
Journal: JAMA (1978)

TRAUMATIC laceration of the gallbladder with subsequent bile leakage into the peritoneum (choleperitoneum) is a rare complication of blunt abdominal trauma. Fewer than 50 cases have been reported in the English literature. Most cases have involved either children or adolescents, as the incidence of accidents in this group is the highest. The occasional cases reported in adults are usually secondary to steering wheel or seat belt injuries. If no other visceral organ is damaged and there are no signs of shock or hemoperitoneum, the delay in diagnosis can be as long as six weeks. In the rare instance when the patient has known chronic liver disease and ascites, the diagnosis may be further delayed. We present a case in which the diagnosis was established seven weeks after admission with the aid of a "skinny-needle" percutaneous transhepatic cholangiogram (PTC). <h3>Report of a Case</h3> A 53-year-old man was admitted to the hospital
Success of Endoscopic Injection Therapy in Correlation with Maximal One-Day Transfusion Requirement
Authors: J.-J. Chen, C.-S. Changchien, D.-I. Tai, S.-S. Chiou, C.-M. Lee, C.-H. Kuo, K.-W. Chiu, S.-K. Chuah, C.-C. Lin
Journal: Endoscopy (1995)

Background and Study Aims: The rate of blood transfusion is related to blood flow and the diameter of the bleeding vessel. Therapeutic endoscopy is less effective in larger vessels. To determine the effect of therapeutic endoscopy with pure ethanol injection in massive peptic ulcer bleeding, we conducted a retrospective study using the maximal one-day blood requirement as an indicator of the required blood transfusion.
Protein tyrosine phosphatase <scp>SHP</scp>2 regulates <scp>TGF</scp>‐β1 production in airway epithelia and asthmatic airway remodeling in mice
Authors: X.‐J. Qin, G.‐S. Zhang, X. Zhang, Z.‐W. Qiu, P.‐L. Wang, Y.‐W. Li, W. Li, Q.‐M. Xie, Y.‐H. Ke, J. J Lee, H.‐H. Shen
Journal: Allergy (2012)

Abstract Background Transforming growth factor ( TGF )‐β1 produced in airway epithelia has been suggested as a contributor to the airway remodeling observed in asthma patients. The protein tyrosine phosphatase SHP 2 is a demonstrable modulator of TGF ‐β1 production and thus a potential regulator of airway remodeling. Objectives To define the signal event by which SHP2 regulates asthmatic responses in airway epithelial cells by using a mouse model of experimental OVA‐induced airway remodeling. Methods The airways of Shp2 flox/flox mice were infected with recombinant adenovirus vectors expressing a Cre recombinase–green fluorescence protein ( GFP ) fusion protein as part of allergen provocation studies using mice sensitized with ovalbumin ( OVA ) and repeatedly challenged with OVA . Several endpoint pathologies were assessed, including airway hyper‐responsiveness ( AHR ), lung inflammatory score, peribronchial collagen deposition, and α‐smooth muscle actin ( SMA ) hyperplasia. In vitro studies using airway epithelial cells ( BEAS ‐2B) were used to investigate the role of SHP 2 in the regulation of pulmonary remodeling events, including the expression of collagen, α‐ SMA , and TGF ‐β1. Results Chronic OVA challenges in wild‐type mice resulted in airway remodeling and lung dysfunction (e.g., increased inflammatory scores, collagen deposition (fibrosis), smooth muscle hyperplasia, and a significant increase in AHR ). These endpoint pathology metrics were each significantly attenuated by conditional shp2 gene knockdown in airway epithelia. In vitro studies using BEAS ‐2B cells also demonstrated that the level of TGF ‐β1 production by these cells correlated with the extent of shp2 gene expression. Conclusions SHP 2 activities in airway epithelial cells appear to modulate TGF ‐β1 production and, in turn, regulate allergic airway remodeling following allergen provocation. Clinical Implications Our findings identify SHP 2 as a previously underappreciated contributor to the airway remodeling and lung dysfunction associated with allergen challenge. As such, SHP 2 represents a potentially novel therapeutic target for the treatment of asthmatics. Capsule summary Airway epithelial protein tyrosine phosphatase SHP 2 appears to modulate TGF ‐β1 activities as part of one or more cellular pathways leading to regulating the airway remodeling and lung dysfunction occurring in mouse models of allergic respiratory inflammation.
Short stature and diabetic nephropathy
Authors: P Rossing, L Tarnow, F S Nielsen, S Boelskifte, B M Brenner, H-H Parving
Journal: BMJ (1995)

A high participation rate in anonymous HIV surveillance resulted from frank discussion with prisoners, use of saliva samples, and, for study purposes, self completion questionnaires * The proportion of injecting drug users differed according to residence before prison: 41% of Glasgow residents, 21% of Edinburgh residents, and 11% of those resident else- where * A quarter of injecting drug users in Glenochil prison had started injecting while in some prison * Between a quarter and a third of men who
Rosiglitazone Lowers Blood Pressure and Increases Arterial Compliance in Postmenopausal Women With Type 2 Diabetes
Authors: Suzy Y. Honisett, Lily Stojanovska, Krishnankutty Sudhir, Bronwyn A. Kingwell, Tye Dawood, Paul A. Komesaroff
Journal: Diabetes Care (2003)

Diabetes is associated with stiff large arteries, which plays an important role in the pathogenesis of vascular disease (1) and is the primary cause of mortality and morbidity with type 2 diabetes. Similarly, after menopause, women experience a dramatic increase in large artery stiffness and the rate of cardiovascular disease (2). Thiazolidinediones modulate glucose homeostasis (3) and exhibit a number of potential antiatherogenic actions (3), the collective effects of which remain to be fully elucidated in humans.

We therefore investigated whether rosiglitazone, the second member of the thaizolidinediones group, would improve blood pressure and arterial compliance, …
Ejection fraction response to supine exercise in asymptomatic aortic regurgitation: Relation to simultaneous hemodynamic measurements
Authors: Barry M. Bassie, Barry L. Kramer, Debra Loge, Nina Topic, Barry H. Greenberg, Melvin D. Cheitlin, J. David Bristow, Randolph C. Byrd
Journal: Journal of the American College of Cardiology (1985)
The Transmission of Yellow Fever.
Authors: A. M. Fernandez Ybarra
Journal: JAMA (1903)

New York City, Aug. 11, 1903. <h3>To the Editor:</h3> —On my arrival from Cuba I perused with great interest the article of Dr. James Carroll on "The Transmission of Yellow Fever," published inThe Journal, May 23, 1903, the replies made to it by Drs. Carlos I. Finlay and Aristides Agramonte, both of Havana, Cuba, and Dr. Carroll's last rejoinder. I wish briefly to state a few facts on the matter discussed by pointing out the principal differences between the experiments of Drs. Finlay and Delgado, on one side, and the Army Yellow Fever Commission on the other. The contrast is truly remarkable, and fully explains the point in question. Finlay and Delgado were trying to find in the<i>culex</i>mosquito a prophylactic agent by means of which they could make non-immune persons immune to yellow fever, very much as it happens with the vaccine virus against smallpox; and the
PHYSICAL SIGNS IN SCHIZOPHRENIA
Authors: THEOPHIL KLINGMANN
Journal: American Journal of Psychiatry (1946)

1. Physical signs in schizophrenia are listed and classified according to type. 2. A sign of which no previous mention has been found in the literature is described—spasm of the radial arteries. It is very frequent in catatonic schizophrenia, and is of some diagnostic value. It is apparently related to the other signs of sympathicotonia seen in the hands and feet, but is more constant. 3. It is suggested that similar vasospasm in the brain might cause organic changes resulting in schizophrenia, and the desirability for further studies along these lines is emphasized.
The Long-Term Effects of In Utero Exposures — The DES Story
Authors: Annekathryn Goodman, John Schorge, Michael F Greene
Journal: New England Journal of Medicine (2011)

In 1971, Herbst et al. reported an association between in utero exposure to diethylstilbestrol (DES) and development of clear-cell adenocarcinoma of the vagina — changing medical thinking about embryologic development of the genital tract and mechanisms of carcinogenesis.
A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression
Authors: John J. Farrell, Richard M. Sherva, Zhi-yi Chen, Hong-yuan Luo, Benjamin F. Chu, Shau Yin Ha, Chi Kong Li, Anselm C. W. Lee, Rever C. H. Li, Chi Keung Li, Hui Leung Yuen, Jason C. C. So, Edmond S. K. Ma, Li Chong Chan, Vivian Chan, Paola Sebastiani, Lindsay A. Farrer, Clinton T. Baldwin, Martin H. Steinberg, David H. K. Chui
Journal: Blood (2011)
843 A SYNTHETIC CODON-OPTIMIZED HCV NON-STRUCTURAL 5A DNA VACCINE PRIMES POLYFUNCTIONAL CD8+ T CELL RESPONSES IN WILDTYPE AND NS5A-TRANSGENIC MICE
Authors: F. Holmstrom, M. Kriegs, E. Hildt, M. Sallberg, G. Ahlen, L. Frelin
Journal: Journal of Hepatology (2012)
Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII
Authors: Paris Margaritis, Valder R. Arruda, Majed Aljamali, Rodney M. Camire, Alexander Schlachterman, Katherine A. High
Journal: Journal of Clinical Investigation (2004)

Hemophilia is a bleeding disorder caused by mutations in the genes encoding coagulation Factor VIII (FVIII) or FIX. Current treatment is through intravenous infusion of the missing protein. The major complication of treatment is the development of neutralizing Ab's to the clotting factor. Infusion of recombinant activated human Factor VII (rhFVIIa), driving procoagulant reactions independently of human FVIII (hFVIII) or hFIX, has been successful in such patients and could in theory provide hemostasis in all hemophilia patients. However, its high cost and short half-life have limited its use. Here, we report a novel treatment strategy with a recombinant adeno-associated virus vector delivering a modified FVII transgene that can be intracellularly processed and secreted as activated FVII (FVIIa). We show long-term expression, as well as phenotypic correction of hemophilia B mice following gene transfer of the murine FVIIa homolog, with no evidence of thrombotic complications at these doses. These data hold promise for a potential treatment for hemophilia and other bleeding disorders.
Clinical Heterogeneity Among Patients With Gaucher's Disease
Authors: Ellen Sidransky
Journal: JAMA (1993)

<h3>SELECTED CASES</h3><h3>Case 1</h3> A girl born at term to nonconsanguineous parents by spontaneous vaginal delivery had normal early developmental milestones. She smiled at 9 weeks, cooed at 10½ weeks, and rolled over at 14 weeks. However, she developed constant irritability and, on examination, was noted to have hepatosplenomegaly. A liver biopsy performed at 7 months of age revealed Gaucher's disease. Her clinical course was characterized by progressive spasticity, respiratory difficulties, and feeding problems. Treatment of seizures and apnea required frequent hospitalizations; however, she died of apnea at 11 months of age. <h3>Comment.</h3> —This child demonstrates the clinical course that is typically associated with type 2 (acute neurologic) Gaucher's disease.<sup>1</sup>Usually, these children are clinically normal at birth and achieve early developmental milestones, but during the first year of life, degenerative neurological disease becomes apparent. The classic clinical triad that rapidly develops includes strabismus, trismus, and hyperextension of the
Rosacea induced by PUVA therapy
Authors: J.P. McFadden, A.V. Powles, M. Walker
Journal: British Journal of Dermatology (1989)

British Journal of DermatologyVolume 121, Issue 3 p. 413-413 Rosacea induced by PUVA therapy J.P. McFadden, J.P. McFadden Department of Dermatology, St Mary's Hospital, London W2, U.K.Search for more papers by this authorA.V. Powles, A.V. Powles Department of Dermatology, St Mary's Hospital, London W2, U.K.Search for more papers by this authorM. Walker, M. Walker Department of Histopathology, St Mary's Hospital, London W2, U.K.Search for more papers by this author J.P. McFadden, J.P. McFadden Department of Dermatology, St Mary's Hospital, London W2, U.K.Search for more papers by this authorA.V. Powles, A.V. Powles Department of Dermatology, St Mary's Hospital, London W2, U.K.Search for more papers by this authorM. Walker, M. Walker Department of Histopathology, St Mary's Hospital, London W2, U.K.Search for more papers by this author First published: September 1989 https://doi.org/10.1111/j.1365-2133.1989.tb01440.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume121, Issue3September 1989Pages 413-413 RelatedInformation
Rat pleural mesothelial cells show damage after exposure to external but not internal cigarette smoke.
Authors: H S Sekhon, B Keeling, A Churg
Journal: Environmental Health Perspectives (1993)

The combination of cigarette smoke and high-level occupational asbestos exposure produces a synergistic increase in the incidence of lung cancer; however, smoking does not affect the incidence of mesothelioma. Here we present the results of tests of two theories that have been proposed to explain this phenomenon; namely, that pleural mesothelial cells are resistant to cigarette smoke-induced damage and that the pleural connective tissue acts as a barrier that prevents smoke from reaching the mesothelial cells. To test these hypotheses, excised whole rat lung preparations were exposed to either internal (intratracheal) or external (pleural surface) smoke. For comparison, additional excised lung preparations were exposed to solutions of hydrogen peroxide either externally or intratracheally. Mesothelial cells exposed to external smoke showed widespread, dose-dependent uptake of Trypan blue. Mesothelial cells did not take up Trypan blue after exposure to internal smoke. Bronchial epithelial cells exposed to internal smoke did show uptake, but to a lesser degree than externally exposed mesothelial cells. Examination by scanning and transmission electron microscopy showed that internal smoke did not affect mesothelial cell ultrastructure, whereas external smoke produced obvious mesothelial cell damage and mesothelial cell detachment. Catalase and deferoxamine, scavengers of active oxygen species, provided protection against smoke-induced mesothelial cell injury, but inactivated catalase did not. External hydrogen peroxide produced a very similar, dose-dependent pattern of Trypan blue uptake and ultrastructural changes. Intratracheal hydrogen peroxide also damaged mesothelial cells, but the extent of damage was always less than with comparable concentrations of external hydrogen peroxide.(ABSTRACT TRUNCATED AT 250 WORDS)
Acne and unemployment
Authors: W.J. Cunliffe
Journal: British Journal of Dermatology (1986)

Journal Article Acne and unemployment Get access W.J. Cunliffe W.J. Cunliffe Department of Dermatology, Leeds General Infirmary, Leeds LS1 3EX, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 3, 1 September 1986, Page 386, https://doi.org/10.1111/j.1365-2133.1986.tb05757.x Published: 01 September 1986
Circulating immunoreactive endothelin in patients undergoing percutaneous transluminal coronary angioplasty
Authors: Akira Tahara, Masakazu Kohno, Shiro Yanagi, Hiroshi Itagane, Iku Toda, Kaname Akioka, Masakazu Teragaki, Mitsutaka Yasuda, Kazuhide Takeuchi, Tadanao Takeda
Journal: Metabolism (1991)
Hepatic Coma
Authors: T. Lynch Murphy, Thomas C. Chalmers, Richard D. Eckhardt, Charles S. Davidson
Journal: New England Journal of Medicine (1948)

PROLONGED coma has been recognized as a frequent terminal event of both acute hepatic necrosis and chronic hepatic fibrosis. Frerichs,1 in 1860, described the terminal mental changes in patients with acute yellow atrophy and with cirrhosis of the liver:Cases have occurred to me in which individuals who for a long period have suffered from cirrhosis of the liver, have suddenly presented a series of morbid symptoms which are foreign to that disease. They have become unconscious, and have been afterwards seized with noisy delirium, from which they passed to deep coma, and in this state have died. In most . . .
Mechanisms of anterior cruciate ligament injury in world cup alpine skiing: a systematic video analysis of 20 cases
Authors: T Bere, T W Flørenes, T Krosshaug, H Koga, L Nordsletten, C Irving, E Muller, R C Reid, V Senner, R Bahr
Journal: British Journal of Sports Medicine (2011)

Background We have limited insight into the mechanisms of anterior cruciate ligament (ACL) injuries in alpine skiing, particularly among professional ski racers. Objective To describe the mechanisms of ACL injury in World Cup alpine skiing. Design Descriptive video analysis. Setting World Cup alpine skiing. Methods 20 cases of ACL injuries reported through the International Ski Federation Injury Surveillance System for three consecutive World Cup seasons (2006–2009) were obtained on video. Seven international experts performed visual analyses of each case to describe the injury mechanisms in detail (skiing situation, skier behaviour, biomechanical characteristics). Results Three main categories of injury mechanisms were identified: the slip-catch, landing back-weighted and the dynamic snowplow. The slip-catch mechanism accounted for half of the cases (n=10), and all these injuries occurred during turning, without or before falling. The skier lost pressure on the outer ski, and while extending the outer knee to regain grip, the inside edge of the outer ski abruptly caught in the snow, forcing the knee into internal rotation and valgus. The same loading pattern was observed for the dynamic snowplow (n=3). The landing back-weighted category included cases (n=4) where the skier was out of balance backwards in-flight after a jump and landed on the ski tails with nearly extended knees. The suggested loading mechanism was a combination of tibiofemoral compression, boot induced anterior drawer and quadriceps anterior drawer. Conclusion A consistent pattern was observed where the main mechanism of ACL injury in World Cup alpine skiing appeared to be a slip-catch situation where the outer ski suddenly catches the inside edge, abruptly forcing the outer knee into internal rotation and valgus. A similar loading pattern was observed for the dynamic snowplow. Injury prevention efforts should focus on the slip-catch mechanism and the dynamic snowplow.