Lipoprotein(a) in Acromegaly
Authors: Pietro Maffei
Journal: Annals of Internal Medicine (1999)

Letters16 March 1999Lipoprotein(a) in AcromegalyPietro Maffei, MD, Nicola Sicolo, MD, and Mario Plebani, MDPietro Maffei, MDUniversità degli Studi di Padova; 35100 Padova, Italy (Maffei)Università degli Studi di Padova; 35100 Padova, Italy (Sicolo)Azienda Ospedaliera di Padova; 35100 Padova, Italy (Plebani)Search for more papers by this author, Nicola Sicolo, MDUniversità degli Studi di Padova; 35100 Padova, Italy (Maffei)Università degli Studi di Padova; 35100 Padova, Italy (Sicolo)Azienda Ospedaliera di Padova; 35100 Padova, Italy (Plebani)Search for more papers by this author, and Mario Plebani, MDUniversità degli Studi di Padova; 35100 Padova, Italy (Maffei)Università degli Studi di Padova; 35100 Padova, Italy (Sicolo)Azienda Ospedaliera di Padova; 35100 Padova, Italy (Plebani)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-6-199903160-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Lipoprotein(a) is a genetically regulated atherogenic lipoprotein (1). Acromegaly is characterized by premature cardiovascular mortality and morbidity, but the precise pathways by which it occurs are unknown (2, 3). Although growth hormone greatly influences lipid metabolism (4), hypertriglyceridemia has been observed in some studies but not in others (2). Moreover, elevated as well as reduced cholesterol concentrations have been observed, whereas little is known about lipoprotein(a) levels (5). We assessed lipid measures in patients with acromegaly.Forty-two acromegalic patients (21 men and 21 women; mean age ± SD, 48 ± 12 years), and 57 controls (24 men ...References1. Utermann G. The mysteries of lipoprotein(a). Science. 1989;246:904-10. CrossrefMedlineGoogle Scholar2. Saccà L, Cittadini A, Fazio S. Growth hormone and the heart. Endocr Rev. 1994;15:555-73. CrossrefMedlineGoogle Scholar3. Maffei P, Corfini A, de Carlo E, Martini C, Bozza G, Photiou E, et al . Gender-dependent variability of signal-averaged electrocardiogram in acromegaly. Cardiology. 1995;86:114-9. CrossrefMedlineGoogle Scholar4. Davidson MB. Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev. 1987;8:115-31. CrossrefMedlineGoogle Scholar5. Lam KS, Pang RW, Janus ED, Kung AW, Wang CC. Serum apolipoprotein(a) correlates with growth hormone levels in Chinese patients with acromegaly. Atherosclerosis. 1993;104:183-8. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Pietro Maffei, MD; Nicola Sicolo, MD; Mario Plebani, MDAffiliations: Università degli Studi di Padova; 35100 Padova, Italy (Maffei)Università degli Studi di Padova; 35100 Padova, Italy (Sicolo)Azienda Ospedaliera di Padova; 35100 Padova, Italy (Plebani) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of endocrine disorders on lipids and lipoproteinsLipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice GuidelineThe Endothelium in AcromegalyPreclinical markers of atherosclerosis in acromegaly: a systematic review and meta-analysisAmbulatory arterial stiffness indexes in acromegalyIncreased oxidized low density lipoprotein associated with high ceruloplasmin activity in patients with active acromegalyAlterations in biomarkers of cardiovascular disease (CVD) in active acromegalyDistúrbios cardiovasculares na acromegaliaImprovement of Endothelial Dysfunction in Acromegaly after Transsphenoidal SurgeryIncrease of Classic and Nonclassic Cardiovascular Risk Factors in Patients with AcromegalySystemic Complications of Acromegaly: Epidemiology, Pathogenesis, and ManagementCardiac Abnormalities in AcromegalyLow plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities in growth hormone deficient and acromegalic men: role in altered high density lipoproteinsEffects of normalization of GH hypersecretion on lipoprotein(a) and other lipoprotein serum levels in acromegaly 16 March 1999Volume 130, Issue 6Page: 537-538KeywordsAcromegalyBlood plasmaGrowth hormoneHypercholesterolemiaInsulin-like growth factorsLipid metabolismLipidsLipoproteinsMorbidityMortality ePublished: 15 August 2000 Issue Published: 16 March 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...