tbuckley/cabot-search huggingface dataset:
Effects of load alteration and coronary perfusion pressure on regional end-systolic relations.
Authors: W P Miller, B P Flygenring, S H Nellis
Journal: Circulation (1988)

Left ventricular end-systolic pressure-wall thickness and pressure-segment length relations have been used to assess regional myocardial contractility. The purpose of these studies was to determine whether the method of afterload alteration, coronary perfusion pressure, and the definition of end systole affected regional end-systolic relations. In paced open-chest pig hearts (n = 10), left ventricular pressure, wall thickness, and segment length were measured during vena caval occlusions. First, regional end-systolic relations were obtained before and after an increase in afterload with intravenous phenylephrine. This comparison was performed with the coronary circulation intact (closed loop) and with coronary perfusion pressure controlled extracorporeally (open loop). Second, with the open-loop preparation, the independent effect of a range of coronary perfusion pressures (45-155 mm Hg) on end-systolic relations was assessed. In both procedures, end systole was defined by the maximal isochronal slope, termed regional Emax, and by the maximal ratio of left ventricular pressure to regional dimension, termed Ees. In the first procedure, the slope and x-axis intercept of regional Emax were unchanged with phenylephrine. In contrast, the slope of Ees decreased with phenylephrine, consistent with a decrease in contractility. The extrapolated x-axis intercept of Ees shifted in a direction consistent with an increase in contractility. In the second procedure, increases in coronary perfusion pressure did not affect regional Emax but increased the slope of Ees. A decrease in the coronary perfusion pressure, particularly with ischemia, shifted the x-axis intercepts of both Emax and Ees in a direction consistent with a decrease in contractility. Thus, regional end-systolic relations in intact hearts are dependent on the method of afterload alteration and the coronary perfusion pressure. Furthermore, Emax differs from Ees, so the assessment of regional relations depends on how end systole is defined.
917-95 Reduced LDL-Cholesterol Levels are Associated with Reduced Levels of Hemostatic Risk Factors in the Framingham Offspring Study
Authors: Francine K. Welty, Peter WF. Wilson, Murray A. Mittleman, Patrice A. Sutherland, Travis H. Matheney, Izabella Lipinska, James E. Muller, Daniel Levy, Geoffrey H. Tofler
Journal: Journal of the American College of Cardiology (1995)
Aquagenic Urticaria
Authors: Walter B. Shelley, Howard M. Rawnsley
Journal: JAMA (1964)

For years a distinctive and intensely pruritic form of hives has been noted in certain people as a result of heat, emotion, or exertion. The numerous small lesions have been labeled "cholinergic urticaria." Critical wetting of the sensitive areas of the skin surface, which triggers cholinergic urticaria, can be achieved by a few minutes immersion in a water bath, contact with distilled water, or sweating itself. Water reacts with a component of the sebum or sebaceous gland to produce a histamine liberator which is absorbed with subsequent discharge of histamine from the perifollicular mast cells. This produces pruritus, axon-reflex erythema, and follicular urticaria. Inert oil coating of the skin and systemic antihistaminics have been found effective in preventing attacks.
Thyroid Function Screening in Psychiatric Patients-Reply
Authors: Kenneth L. Cohen
Journal: JAMA (1980)

In Reply.—  We appreciate the comments by Dr Wiener but wish to clarify a few points. First, although a diagnosis of secondary hypothyroidism was made in eight patients with low thyroxine and normal thyroid-stimulating hormone levels, only one clearly had a pituitary gland lesion. The others may well have had a hypothalamic disorder—tertiary hypothyroidism. Thyrotropin-releasing hormone (TRH) testing, which was not available at the time of our study, would have helped to confirm that diagnosis. The need for thyroxine therapy in hypothalamic hypothyroidism has not been established, although we have seen several patients who were sufficiently symptomatic to warrant a trial of hormone replacement. Second, in addition to finding a modest number of new cases, the screening tests uncovered another group of patients with previously diagnosed thyroid disease who were taking inappropriate amounts of thyroid hormone, possibly contributing to their acute psychiatric problems. We think that the yield of the
Psychoanalysis, Psychotherapy and the New England Medical Scene, 1894-1944
Authors: Marjorie C. Meehan
Journal: JAMA (1978)

Although it has been a long time since Boston could claim to be the intellectual hub of the universe, New England was indeed an important center of psychiatric development in the late 19th and early 20th centuries. The influence of some leaders of that time—William James, G. Stanley Hall, even Mary Baker Eddy—is still felt. Many of today's psychiatrists and psychoanalysts received their early training and inspiration in Boston and took their direction from such leaders as William Healy, Macfie Campbell, and Helene Deutsch. It was a happy thought of George Gifford to arrange a symposium to discuss psychotherapeutic activity in New England from 1894 to 1944. Historians, psychiatrists, psychologists, and psychoanalysts, including some of the historymakers themselves, took part. This volume comprises the papers presented at this symposium, held in Boston in 1973, together with a panel discussion of Boston psychoanalytic history. Many photographs add greatly to the interest.
Pulmonary and Osseous Eosinophilic Granuloma
Authors: John R. Williams, William O. Pischnotte, Billy P. Sammons, Martin F. Sokoloff
Journal: New England Journal of Medicine (1957)

EOSINOPHILIC granuloma with both osseous and pulmonary involvement, pathologically proved, was first described by May, Garfinkle and Dugan1 in 1954, with a report of 3 cases. Since that time only 1 such case has been reported — by Childers, Middleton and Schneider2 in 1955.Because of the apparent rarity of this combination of bone and lung involvement the following case is presented.Case ReportA 21-year-old sailor was well until June, 1956, when he was awakened at night with a dull ache in the area of the posterior distal left humerus. The discomfort continued and became progressively worse; it was . . .
High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML
Authors: A Jo, S Mitani, N Shiba, Y Hayashi, Y Hara, H Takahashi, I Tsukimoto, A Tawa, K Horibe, D Tomizawa, T Taga, S Adachi, T Yoshida, H Ichikawa
Journal: Leukemia (2015)
THE VALUE OF A MIXTURE OF CYLLIN, IODOFORM, AND OLIVE OIL IN INTRATHORACIC SEPSIS
Authors: W. Gordon, M. E. Gates
Journal: BMJ (1918)

I.THE sterilization of septic wounds followed by secondarv suture or closure, lhaving for its objects tlle shiortening of the patient's stay in hospital and the lessening of impair- ment of function, is tlle ambition of most army lhospitals to-day.Many brilliant successes lhave been recorded by those following the various metlhods in vogue.Several, on account of a few failures, have become sceptical about the results claimed by otlhers, and lhave drifted back to pre- war methods.An analysis of failures often teaches us muclh.The flora of all septic wounds consists of a conglomerate variety of bacteria-staplhylococcus, streptocbecus, p)yocyaneuts,
A functional and structural basis for TCR cross-reactivity in multiple sclerosis
Authors: Heather L.E. Lang, Helle Jacobsen, Shinji Ikemizu, Christina Andersson, Karl Harlos, Lars Madsen, Peter Hjorth, Leif Sondergaard, Arne Svejgaard, Kai Wucherpfennig, David I. Stuart, John I. Bell, E. Yvonne Jones, Lars Fugger
Journal: Nature Immunology (2002)
At last---maternity statistics for England
Authors: A. Macfarlane
Journal: BMJ (1998)

After a long gestation the Department of Health has finally delivered a bulletin on maternity statistics.1 Few routine data on maternity care in England have been published since 1985, the last year of the old Hospital In-patient Enquiry. This lack has been equally frustrating to people who want to compare local performance with national statistics and those who want to monitor national trends. 2 3 Not surprisingly, the new statistics show many changes in maternity care since 1985, while revealing inadequacies in the data.

The Maternity Hospital Episode Statistics system,4 through which the data are collected, started in April 1989, and the new publication contains data for 1994-5 and trends since 1989-90. It is restricted to data about care during delivery, but a further bulletin with data for 1995-6 and 1996-97, including antenatal and postnatal episodes and data about newborn babies, is promised for the autumn. Subsequent bulletins will then appear annually.

The most dramatic changes are in caesarean section rates and the methods of operative vaginal deliveries (see figure). The caesarean section rate, which levelled off at just above 10% of …
Duodenal duplication cyst presenting with gastric outlet obstruction in an adult male
Authors: A. McArdle, J. Conneely, N. Ravi, J. Reynolds
Journal: Endoscopy (2011)

A 25-year-old man presented with postprandial vomiting and abdominal pain. He had no significant past medical history and had a normal physical examination. Duodenoscopy and endoscopic ultrasound (EUS) revealed an obstructing, intra-luminal, cystic mass in the third part of the duodenum (D3) ([Fig. 1]).
Double-blind Controlled Trial of a Micronized Preparation of Flumedroxone (Demigran) in Prophylaxis of Migraine
Authors: W. G. Bradley, P. Hudgson, J. B. Foster, D. J. Newell
Journal: BMJ (1968)

A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine. No benefit was found in males, or in females with no history of menstrual exacerbation of migraine. In women whose migraine was worse around the time of menstruation flumedroxone resulted in statistically fewer headaches of less severity. With the dose used in this trial (micronized flumedroxone 10 mg. t.d.s.) side-effects were frequent, the commonest being polymenorrhagia, which occurred in half the women of reproductive age.
Are Critical Deterioration Events the Right Metric to Determine the Impact of Rapid Response Systems?
Authors: Rashid Alobaidi, Ari R. Joffe
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
O83 NON-INVASIVE DIAGNOSIS OF LIVER FIBROSIS BY FIBROSCAN IN PATIENTS WITH ALCOHOLIC LIVER DISEASE: A META-ANALYSIS WITH INDIVIDUAL DATA
Authors: E. Nguyen-Khac, P. Nahon, J. Boursier, C. Moreno, P. Starkel, S. Mueller, V. de Ledinghen, S. Giune Kim, M. Fernandez, E. Trepo, M. Ziol, D. Chatelain, M. Diouf
Journal: Journal of Hepatology (2014)
Enzalutamide Antitumour Activity Against Metastatic Castration-resistant Prostate Cancer Previously Treated with Docetaxel and Abiraterone: A Multicentre Analysis
Authors: Klaus Brasso, Frederik B. Thomsen, Andres J. Schrader, Sebastian C. Schmid, David Lorente, Margitta Retz, Axel S. Merseburger, Christoph A. von Klot, Martin Boegemann, Johann de Bono
Journal: European Urology (2014)
Renal Cell Carcinoma Detected on Tc-99m-Labeled Red Blood Cell Imaging
Authors: Julia Cortes, Juan I. Alonso, Francisco Ruiz–Oliva, Soledad Alvarez, Julio Saenz Ormijana, Blanca Caton, Pilar Alcorta
Journal: Clinical Nuclear Medicine (2003)

A 61-year-old-man with persistent anemia was referred for a Tc-99m-labeled red blood cell (RBC) scan to detect any source of gastrointestinal bleeding. RBC scintigraphy revealed a hypervascular mass in the left renal fossa with functional loss in that kidney, suggesting the possibility of a renal cell carcinoma (RCC). Computed tomography confirmed this. Most RCC tumors are hypervascular on conventional angiography, with a maximum incidence in men in the sixth decade. The incidental diagnosis of RCC during radionuclide imaging has been documented in previous reports, but the authors are not aware of any case of RCC diagnosed during a RBC scan. This case illustrates the importance of careful attention to the appearance of the kidneys on radionuclide scans. Noticeable asymmetric renal activity in a patient without known renal parenchymal disease warrants further investigation.
The Effects of Capitation on Health and Functional Status of the Medicaid Elderly
Authors: Nicole Lurie, Jon B Christianson, Michael Finch, Ira S Moscovice
Journal: Annals of Internal Medicine (1994)

Purpose: To determine the effect on health and functional status outcomes of enrollment of noninstitutionalized elderly Medicaid recipients in prepaid plans compared with traditional fee-for-service Medicaid. Design: A randomized, controlled trial. Beneficiaries were randomly assigned to prepaid care in one of seven capitated health plans compared with fee-for-service care. Only the Medicaid portion of their care was capitated. Patients were followed for 1 year. Setting: The Medicaid Demonstration Project in Hennepin County, Minnesota, which includes Minneapolis. Patients: 800 Medicaid beneficiaries who were 65 years or older at the beginning of the evaluation. Beneficiaries were interviewed at baseline (time 1) and 1 year later (time 2). Ninety-six percent of beneficiaries were available for follow-up interviews at time 2. Main Outcome Measures: General health status, physical functioning, mental health status, activities of daily living, instrumental activities of daily living, corrected visual acuity, and blood pressure and glycosylated hemoglobin measurements for hypertensive and diabetic persons, respectively. Results: There were no differences between prepaid and fee-for-service groups in the number of deaths (20 compared with 24, P > 0.2), the proportion in fair or poor health (56.5% compared with 59.7%, P > 0.2), physical functioning, activities of daily living, visual acuity, or blood pressure or diabetic control. Patients in the prepaid group reported a trend toward better general health rating scores (10.2 compared with 9.8, P = 0.06) and well-being scores (10.0 compared with 9.7, P = 0.07) than patients in the fee-for-service group. The difference in the likelihood of a patient in the prepaid group having a physician visit relative to the fee-for-service group was −16.5%(adjusted odds ratio, 0.46; 95% CI, 0.29 to 0.74) and for an inpatient visit was −11.2%(adjusted odds ratio, 0.55; CI, 0.32 to 0.94). Conclusions: There was no evidence of harmful effects of enrolling elderly Medicaid patients in prepaid plans, at least in the short run. Whether these findings also apply to settings in which health maintenance organizations are formed exclusively for Medicaid patients should be studied further.
Tetracycline and benign intracranial hypertension: report of five cases.
Authors: B N Walters, S S Gubbay
Journal: BMJ (1981)

Benign intracranial hypertension occurred in four young women taking tetracycline for acne; two were also taking vitamin A. In a fifth case a 14-year-old boy developed papilloedema after taking a short course of tetracycline for bronchitis. All symptoms disappeared soon after stopping the drugs, though in two cases the papilloedema persisted for many months. Benign intracranial hypertension should be sought in any young woman complaining of headache during treatment with tetracycline. Moreover, young women given vitamin A and tetracycline in combination for acne may be at special risk and should be kept under surveillance.
A study of some factors affecting the mortality rate in diffuse peritonitis
Authors: J. L. Dawson
Journal: Gut (1963)

The results of a retrospective analysis of the records of 665 consecutive patients with diffuse peritonitis emphasize the considerable effect age and causal lesion have on the prognosis. The comparison of results of any innovations in the treatment of diffuse peritonitis cannot be assessed unless these factors are fully taken into account. The fallacy of comparing overall mortality figures is demonstrated. The high mortality rate for diffuse peritonitis associated with diverticulitis is noted.
Oestrogen modulator reduces risk of breast cancer
Authors: S. Gottlieb
Journal: BMJ (1999)

The selective oestrogen receptor modulator raloxifene, currently licensed to treat osteoporosis in postmenopausal women, significantly reduced the risk of breast cancer, according to a study published this week.

In the three year multicentre trial 7705 women below the age of 81 years were randomised to raloxifene or placebo and followed for a median of 40 …
Reasons for Quitting Serotonin Reuptake Inhibitor Therapy: Paradoxical Psychological Side Effects and Patient Satisfaction
Authors: Madelon Y. Bolling, Robert J. Kohlenberg
Journal: Psychotherapy and Psychosomatics (2004)

&lt;i&gt;Background:&lt;/i&gt; The goal of this study was to document the existence of psychological side effects associated with serotonin reuptake inhibitors (SSRIs) taken for depression and to determine their relationship to patients’ decisions to stop treatment, and attitudes toward taking SSRIs again. &lt;i&gt;Method:&lt;/i&gt; We conducted 161 semi-structured telephone interviews of adults who had completed a course of treatment for depression with one of the SSRIs. We identified 29 categories of unwanted psychological effects and analyzed data in terms of responders and non-responders, the former split into those who would, and those who would not take the same drug again if depressed in the future (‘take-again responders’ and ‘not-again responders’, respectively). &lt;i&gt;Results:&lt;/i&gt; Psychological side effects were cited just as often as physical side effects as the primary reason for quitting SSRI treatment. Non-responders cited psychological side effects rather than non-response as the primary reason for quitting, and not-again responders cited physical more than psychological side effects. Not-again responders and non-responders did not differ in the number of side effects experienced, and non-responders experienced significantly more unwanted psychological effects than either type of responder (χ&lt;sup&gt;2&lt;/sup&gt; = 6.767, p = 0.009). &lt;i&gt;Conclusion:&lt;/i&gt; Psychological side effects might well be included in measures and discussions of side effects, even though they present no known physical danger to the patient.
AMINO (HYDROXYETHOXYMETHYL) PURINE: A NEW WELL-ABSORBED PRODRUG OF ACYCLOVIR
Authors: P. Selby, S. Blake, E.K. Mbidde, E. Hickmott, R.L. Powles, K. Stolle, T.J. Mcelwain, P.D. Whiteman, A.P. Fiddian
Journal: The Lancet (1984)
Response to Comments by Minoli and Prada
Authors: J.-J. Gonvers, F. Froehlich, B. Burnand, I. Pache, J. Thorens, M. Fried, J. P. Vader
Journal: Endoscopy (1997)

See also: Appropriateness and Diagnostic Yield of Upper Gastrointestinal Endoscopy in an Open-Access Endoscopy UnitEndoscopy 1996; 28(08): 661-666DOI: 10.1055/s-2007-1005573
John Lawson Griffiths
Authors: B. Griffiths
Journal: BMJ (2003)

General practitioner Pen-coed, south Wales, 1951-95 (b Swansea 1925; q St Mary's Hospital, London, 1950), d 10 July 2002.

John was in general practice in Pen-coed, south Wales, until his retirement, aged 70. In 1957, while still working his general practice rota, he went into partnership with a mining engineer and opened the first of their three coal mines. The mines were a financial success, supplying domestic coal and anthracite to local homes and industrial estates. In 1969 John started building his holiday house in Newport, Pembrokeshire, and in 1980 he began to develop the land on the periphery of his farmhouse, masterminding planning, drainage, roads, and facilities. He was in the midst of his next housing development when he died suddenly following minor dental surgery. He leaves a wife, Pat; three children; and seven grandchildren.
Autonomic modulation of aminophylline influence on the electrophysiological effects of adenosine and adenosine triphosphate in the canine heart
Authors: B. BELHASSEN, R. ILIA, A. M GREENSPAN, L. N HOROWITZ
Journal: Cardiovascular Research (1987)

Journal Article Autonomic modulation of aminophylline influence on the electrophysiological effects of adenosine and adenosine triphosphate in the canine heart Get access BERNARD BELHASSEN, BERNARD BELHASSEN From the Cardiac Electrophysiology Laboratory, Likoff Cardiovascular Institute, Hahnemann University, Philadelphia, Pennsylvania, USA Address for correspondence and reprints: Dr Bernard Belhassen, Cardiac Electrophysiology Laboratory, Tel Aviv Medical Center, Ichilov Hospital, Tel Aviv 64239, Israel. Search for other works by this author on: Oxford Academic PubMed Google Scholar REUBEN ILIA, REUBEN ILIA From the Cardiac Electrophysiology Laboratory, Likoff Cardiovascular Institute, Hahnemann University, Philadelphia, Pennsylvania, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar ALLAN M GREENSPAN, ALLAN M GREENSPAN From the Cardiac Electrophysiology Laboratory, Likoff Cardiovascular Institute, Hahnemann University, Philadelphia, Pennsylvania, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar LEONARD N HOROWITZ LEONARD N HOROWITZ From the Cardiac Electrophysiology Laboratory, Likoff Cardiovascular Institute, Hahnemann University, Philadelphia, Pennsylvania, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 2, February 1987, Pages 151–160, https://doi.org/10.1093/cvr/21.2.151 Published: 01 February 1987 Article history Received: 26 September 1985 Accepted: 02 June 1986 Published: 01 February 1987
Death of the teaching autopsy: Autopsy findings are important to all clinicians, including general practitioners
Authors: B. S Hurwitz
Journal: BMJ (2004)

EDITOR—O'Grady identifies several reasons why autopsy rates have been falling worldwide, in particular why students in New Zealand are now banned from attending autopsies, with resultant loss of undergraduate teaching opportunities.1 However, attending and watching an autopsy are not the only educationally relevant facets of autopsies: their findings are important to all clinicians, including general practitioners.

Whitty et al found that autopsy findings (excluding coroners' reports) were …