tbuckley/cabot-search huggingface dataset:
Giant cell arteritis of the leg in a patient with hepatitis C virus infection
Authors: C. VITALI, E. GALLUZZO, E. M CIANCIA, A. MORETTI, S. MARCHI
Journal: Annals of the Rheumatic Diseases (1997)

14 children, aged between 15 months and 14 years, with brucellosis were treated with oral rifampicin only (20 mg/kg per day) for 3 weeks. Laboratory diagnosis depended on blood culture (positive for Brucella melitensis in 11 of the cases), serum agglutination, complement-fixation test, and Coomb9s test. Response was good in each child, with fever clearing between the 2nd and 8th day. 2 children relapsed, but one relapse was probably a reinfection from contaminated cheese. Both children were given a further course of treatment (rifampicin and co-trimoxazole) which was successful. Despite the reasonably good results with rifampicin alone, it is advisable to combine the drug with co-trimoxazole when treating brucellosis.
Points: Alcohol: still going backwards
Authors: D. Hayter
Journal: BMJ (1986)

has provided a reliable and accurate means of imaging in inflammatory bowel disease.In the 70 scans performed only one false negative result has occurred.The quality of the pictures obtained has been consistently good, as evidenced by the published photographs.Indeed, other centres in Australia have successfully reproduced our findings3 using the labelling methods referred to in our paper.Dr Peters and his colleagues claim to be puzzled that our paper did not report the detection of other inflammatory manifestations of inflammatory bowel disease, such as abscesses, and infer, incorrectly, that the uptake observed by us in inflamed bowel was not due to the migration of inflamed cells but resulted from some poorly understood "non-specific" mechanism.We have indeed observed abscesses and fistulous tracts in our scans of patients with inflammatory bowel disease, but, like the preliminary report of Saverymuttu et al,4 these were not within the scope ofour prelimiary paper.We reiterate the advantages of the 9mTc labelled phagocyte technique for scanning in inflammatory bowel disease.As stated correctly by DrPeters and colleagues, these are considerable: technically simple cell preparation, better image resolution, and lower radiation dose.
877 INCREASED REGULATORY POTENTIAL AND IMBALANCE OF THE VDELTA1/VDELTA2 RATIO IN PATIENTS WITH DIFFERENT MANIFESTATIONS OF HEPATITIS C
Authors: S. Ferri, R. Menichella, M. Bassi, C. De Molo, A.C. Dall'Aglio, A. Granito, G. Pappas, C. Quarneti, P. Muratori, A. Belardinelli, F.B. Bianchi, M. Lenzi, L. Muratori
Journal: Journal of Hepatology (2009)
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q− polycythemia vera
Authors: Fabiana Perna, Nadia Gurvich, Ruben Hoya-Arias, Omar Abdel-Wahab, Ross L. Levine, Takashi Asai, Francesca Voza, Silvia Menendez, Lan Wang, Fan Liu, Xinyang Zhao, Stephen D. Nimer
Journal: Blood (2010)
Epidemiology of Tuberculosis in the United States, 1985 Through 1992
Authors: Michael F. Cantwell
Journal: JAMA (1994)

To examine the distribution and sources of increased tuberculosis (TB) morbidity in the United States from 1985 through 1992.Review of TB surveillance data.All incident TB cases in the United States reported to the Centers for Disease Control and Prevention from 1980 through 1992.Changes in reported number of TB cases from 1985 through 1992 were analyzed by sex, race/ethnicity, age, county of birth (1986 through 1992), site of disease, geographic location, and socioeconomic status (through 1991). From 1985 through 1992, reported number of cases was compared with expected number of cases, extrapolated from 1980 through 1984 trends, to estimate excess cases by sex, race/ethnicity, and age.Increases in number of cases from 1985 through 1992 were concentrated among racial/ethnic minorities, persons 25 to 44 years of age, males, and the foreign-born. Excess cases occurred in both sexes, all racial/ethnic groups, and all age groups. Foreign-born cases accounted for 60% of the total increase in the number of US cases from 1986 through 1992 and had the greatest impact among Asians, Hispanics, females, and persons other than those 25 to 44 years of age. Human immunodeficiency virus infection had the greatest impact on TB morbidity among whites, blacks, males, and persons 25 to 44 years of age. From 1985 through 1992, the number of cases among children 4 years old or younger increased 36%, suggesting that transmission of TB increased during this period.Multiple factors contributed to the recent increases in the number of TB cases. The effectiveness of TB screening in immigrants needs further evaluation. Intensified efforts to determine the human immunodeficiency virus status of persons with TB are needed. Screening of subpopulations at increased risk for tuberculous infection or TB should be expanded.
Multifunctional PEGylated Multiwalled Carbon Nanotubes for Enhanced Blood Pool and Tumor MR Imaging
Authors: Shihui Wen, Qinghua Zhao, Xiao An, Jingyi Zhu, Wenxiu Hou, Kai Li, Yunpeng Huang, Mingwu Shen, Wei Zhu, Xiangyang Shi
Journal: Advanced Healthcare Materials (2014)

Long-circulating multifunctional Gd(III)-loaded multiwalled carbon nanotubes (MWCNTs) modified with polyethylene glycol are designed and synthesized. The formed MWCNTs are water-dispersible, stable, and have good cytocompatibility and antifouling property. With the low r 2/r 1 relaxivity ratio and relatively long blood circulation time, the multifunctional MWCNTs are able to be used as a platform for enhanced blood pool and tumor MR imaging. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
Authors: Alice Bourdon, Limor Minai, Valérie Serre, Jean-Philippe Jais, Emmanuelle Sarzi, Sophie Aubert, Dominique Chrétien, Pascale de Lonlay, Véronique Paquis-Flucklinger, Hirofumi Arakawa, Yusuke Nakamura, Arnold Munnich, Agnès Rötig
Journal: Nature Genetics (2007)
Engineering and physiological approaches to the study of cardiovascular function: alternative or complementary?
Authors: M. I M Noble
Journal: Cardiovascular Research (1992)

Journal Article Engineering and physiological approaches to the study of cardiovascular function: alternative or complementary? Get access Mark I M Noble Mark I M Noble Academic Unit of Cardiovascular Medicine, Charing Cross and Westminster Medical School, 17 Horseferry Road, London SW1P 2AR, United Kingdom Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 3, March 1992, Pages 218–220, https://doi.org/10.1093/cvr/26.3.218 Published: 01 March 1992
Patient groups accuse European parliament of putting economic interests ahead of safety on medical devices
Authors: D. Cohen
Journal: BMJ (2013)

The European parliament has put economic interests ahead of patient safety when it comes to tightening regulation of medical devices, several patient groups and members of the European parliament have said.

The criticisms come after MEPs voted to change how certain—but not all—high risk medical devices come on to the market. Other changes to their regulation have been watered down over time too.

Ilaria Passarani, senior health policy officer at the European Consumer Organisation said, “Unfortunately, in this time of economic crisis, arguments regarding jobs, growth and innovation have greater weight than arguments about patient safety.”

Christian Zahn, vice president of AIM, the International Association of Mutual Benefit Societies, many of whose members have to decide which products to reimburse in their countries, said that “the opportunity to improve the safety of patients is wasted.”

“I am surprised that economic reasons are more important …
221 IS EXPANDING MILAN CRITERIA SAFE? USE OF EXPANDED CRITERIA FOR LIVER TRANSPLANT DOES NOT SIGNIFICANTLY DECREASE OUTCOMES IN PATIENTS WITH HEPATOCELLULAR CARCINOMA
Authors: Q. Lai, A. Avolio, G. Tisone, A. Molinaro, F. Melandro, S. Agnes, P.B. Berloco, M. Rossi
Journal: Journal of Hepatology (2010)
Prognostic Indicators for Coronary Artery Disease
Authors: Robert E. Goldstein, Eric S. Holmboe
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proliferation of Cardiac Technology in Canada
Authors: David A. Alter, Therese A. Stukel, Alice Newman
Journal: Circulation (2006)

Background— Critics remain skeptical about the long-term sustainability of Medicare in Canada because of the proliferation of health technology and escalating expenditures. The objective of this study was to examine the temporal trends in the utilization and costs of cardiovascular technologies for the evaluation and/or management of patients with ischemic heart disease in Canada. Methods and Results— This repeated cross-sectional population-based study of Ontario residents examined the temporal trends in the utilization and costs associated with echocardiography, stress (imaging and nonimaging) testing, coronary angiography, percutaneous coronary intervention (PCI), and bypass surgery between 1992 and 2001. Annual costs increased by nearly 2-fold over the 10-year study period and cumulatively accounted for more than $2.8 billion (Canadian) in expenditures. The proliferation in use of cardiac testing/interventions over time outstripped both demographic shifts and changes in the prevalence of coronary artery disease. Annual increases were widespread for all procedures ( P &lt;0.001) and ranged from 2% per year for nonimaging stress tests to 12% per year for PCI, after adjustment for age and sex. Generally, utilization rates were higher among the elderly, males, and those of low socioeconomic status. With few exceptions, annual increases in the utilization rates of cardiac tests and procedures were disproportionately higher among the elderly and women, but they were similar across socioeconomic subgroups. Increases in utilization appeared to reflect referrals toward higher-risk populations. Conclusions— Although definitive conclusions about the appropriateness of temporal patterns cannot be ascertained, the proliferation of cardiac testing challenges the sustainability of Medicare in Canada, especially given uncertainty as to whether the accompanying incremental rise in total expenditures translates into significant outcome benefits in the population.
B7-H2 Is a Costimulatory Ligand for CD28 in Human
Authors: Sheng Yao, Yuwen Zhu, Gefeng Zhu, Mathew Augustine, Linghua Zheng, Diana J. Goode, Megan Broadwater, William Ruff, Sarah Flies, Haiying Xu, Dallas Flies, Liqun Luo, Shengdian Wang, Lieping Chen
Journal: Immunity (2011)
Up-Regulation of CysLT2 Receptor Expression and Cysteinyl Leukotrienes-Induced Calcium Signaling By Th2 Cytokines in Human Endothelial Cells
Authors: Hideaki Shirasaki, Etsuko Kanaizumi, Tetsuo Himi, Manabu Fujita
Journal: Journal of Allergy and Clinical Immunology (2015)
The Sequel to a Case of Gastro-Enterostomy
Authors: A. E. Barker
Journal: BMJ (1887)

three eldest are healthy the two youngest are markedly ricketty, the elder of the two has undergone an operation for bow-legs.The' patient's mother is alive and :healthy; his father wasp man of good bodily health, but grieved so over his son's condition that he became deranged and destroyed himself.thepevi.Hi stru come outad aoe it thnbnsuo From a photograph taken when aged 5.
1075 DIRECT NON-INVASIVE SERUM MARKERS OF LIVER FIBROSIS PREDICT FIBROSIS EVOLUTION IN CHRONIC HEPATITIS C BUT ARE INCREASED BY INTERFERON-BASED THERAPY
Authors: S. Tanwar, P.M. Trembling, E. Ellis, J. Parkes, C. Herold, D. Schuppan, W.M. Rosenberg
Journal: Journal of Hepatology (2012)
A prospective cohort study of hamstring injuries in competitive sprinters: preseason muscle imbalance as a possible risk factor
Authors: S S Yeung, A M Y Suen, E W Yeung
Journal: British Journal of Sports Medicine (2009)

Background: Hamstring injuries are common in sprinters. Identifying preseason risk factors is essential to target injury-prone athletes and develop injury preventive measures. Objective: To investigate the incidence of hamstring muscle injury in sprinters over an athletic season and to explore the preseason predictor of this injury. Design: Prospective cohort study. Participants: 44 sprinters from the Hong Kong Sports Institute, the Hong Kong Amateur Athletic Association and intercollegiate athletic teams were recruited. Methods: Preseason assessment of hamstring flexibility, concentric and eccentric isokinetic peak torque and peak torque angle were obtained at the beginning of an athletic season. The athletes were followed over 12 months and were asked to report all injuries resulting from training and competition. Results: Eight athletes sustained hamstring injuries over the season. The injury rate was 0.87 per 1000 h of exposure. The incidence of injuries was higher at the beginning of the season, with 58.3% injuries occurring in the first 100 h of exposure. Cox regression analysis revealed that athletes with a decrease in the hamstring : quadriceps peak torque ratio of less than 0.60 at an angular velocity of 180°/s have a 17-fold increased risk of hamstring injury. Conclusion: Performing preseason hamstring : quadriceps peak torque ratio assessments may be useful to identify sprinters susceptible to hamstring injury.
Simulation in surgical training
Authors: N. Watson
Journal: BMJ (1990)

Acute otitis media SIR,-Mr George G Browning and colleagues state that diagnosing acute otitis media is not easy even when carried out by specialists.'Unfortunately, in two of the studies quoted2 the diagnosis was made predominantly by doctors without specialist training.If only half of children with otalgia have acute otitis media some ofthe figures quoted may be underestimated by a factor of two.Even if the data are accurate, surely a failure of resolution in 15% of "untreated" children is unacceptably high?The advocated policy of withholding antibiotics
Genetic causes of human heart failure
Authors: Hiroyuki Morita, Jonathan Seidman, Christine E. Seidman
Journal: Journal of Clinical Investigation (2005)

Factors that render patients with cardiovascular disease at high risk for heart failure remain incompletely defined. Recent insights into molecular genetic causes of myocardial diseases have highlighted the importance of single-gene defects in the pathogenesis of heart failure. Through analyses of the mechanisms by which a mutation selectively perturbs one component of cardiac physiology and triggers cell and molecular responses, studies of human gene mutations provide a window into the complex processes of cardiac remodeling and heart failure. Knowledge gleaned from these studies shows promise for defining novel therapeutic targets for genetic and acquired causes of heart failure.
Lobbyists' document shows close working between private sector and government over health bill
Authors: G. Iacobucci
Journal: BMJ (2012)

The close relations between private healthcare lobbyists and the prime minister’s office during the “pause” in the passage of the Health and Social Care Bill last year is revealed by a document published this week.

David Worskett, director of the NHS Partners Network, which represents firms such as Care UK, Circle, and UnitedHealth, described the network’s access to the prime minister’s office in a briefing paper published by the Social Investigations blog (http://socialinvestigations.blogspot.co.uk). Health ministers had told him that they shared the network’s views on the key issues, he said. 

The two month “listening exercise,” announced by Prime Minister David Cameron in April 2011, was launched in response to fierce criticism from the medical profession and opposition politicians of the plans to expand competition in the NHS in England.1

The briefing from Worskett, written in May 2011 during the pause, said, “Several members [of the NHS partners network] have used their own …
INHALATION OF BARIUM IN SOLUTION
Authors: C. R. Fishel
Journal: JAMA (1923)

Miss G. W., aged 46, a schoolteacher, referred by Dr. Broman for complete gastro-intestinal examination, which was negative, stated that five years before she had an abscess at the junction of the esophagus and stomach, and that a cavity still remained which she could wash out by the use of salt water and then regurgitate it. <h3>RESULTS OF EXAMINATION</h3> Barium was added to the solution, and she proceeded to wash out the so-called abscess cavity. After one or two unsuccessful attempts she succeeded in getting a liberal amount of the fluid down, which passed directly into the trachea. At the bifurcation, contrary to the usual rule, the greater portion passed into the left bronchus. It passed well out in the smaller bronchi in the lower half of each lung. The patient showed no more inconvenience to the passage of the fluid into the trachea than she would have shown if
For Whose Benefit Do We Write?
Authors: E. F. Wells
Journal: JAMA (1899)

<h3>My Dear Doctor:</h3> —A medical friend of mine recently mentioned in a complimentary way an article you lately read before the Chicago Society of Internal Medicine, entitled "Pulmonary Tuberculosis." I am desirous of securing a scientific clinical report on paper on the therapeutic use of —. This preparation is, as you all know, ethic and scientific, and has been used extensively in phthisis. I would like an article of about a thousand words, and am willing to pay you for your careful observation and report. Of course I want the privilege of publishing the paper in the medical press. If you have the time and inclination to do this work for me, and need literature and samples, I will take pleasure in sending them to you. Thanking you in advance for an early reply, I am, very truly yours, -. Sincerely,
High performance liquid chromatographic separation of eight drugs collected in Chinese Pharmacopoeia 2010 on amylose ramification chiral stationary phase
Authors: Yan Wang, Ying Zhou, Chao Ma, Beibei Yang, Ru Feng, Yiying Zhang, Jie Fu, Wenjing Chen, Yupeng Sun, Jingyi Ma, Qiming Zhang, Yulin Deng, Yukui Zhang, Wenyi He
Journal: Acta Pharmaceutica Sinica B (2012)

The enantiomers separation of eight pharmaceutical racemates collected in Chinese Pharmacopoeia 2010 (Ch.P2010), including nitrendipine, felodipine, omeprazole, praziquantel, sulpiride, clenbuterol hydrochloride, verapamil hydrochloride and chlorphenamine maleate, was performed on chiral stationary phase of amylose ramification by high performance liquid chromatography (HPLC) on Chiralpak AD-H column and Chiralpak AS-H column with the mobile phase consisted of isopropanol and n-hexane. The detection wavelength and the flow rate were set at 254 nm and 0.7 mL/min, respectively. The effects of proportion of organic additives, alcohol displacer and temperature on the separation were investigated. The results indicated that eight chiral drugs were separated on chiral stationary phase of amylase ramification in normal phase chromatographic system. The chromatographic retention and resolution of enantiomers were adjusted by factors, including the changes of the concentration of alcohol displacer in mobile phase, organic alkaline modifier and column temperature. It was shown that the resolution was improved with reducing concentration of alcohol displacer. When the concentration of organic alkaline modifier was 0.2%, the resolution and the peak shape were fairly good. Most racemates mentioned above had the best resolution at column temperature of 25 °C. The best temperature should be kept unchanged in the process of separation so as to obtain stable separation results.
Oncogenic KRAS promotes malignant brain tumors in zebrafish
Authors: Bensheng Ju, Wenbiao Chen, Brent A Orr, Jan M Spitsbergen, Sujuan Jia, Christopher J Eden, Hannah E Henson, Michael R Taylor
Journal: Molecular Cancer (2015)

Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most devastating and difficult to treat. In this study, we evaluated zebrafish as a brain tumor model by overexpressing a human version of oncogenic KRAS (KRAS(G12V)).Using zebrafish cytokeratin 5 (krt5) and glial fibrillary acidic protein (gfap) gene promoters, we activated Ras signaling in the zebrafish central nervous system (CNS) through transient and stable transgenic overexpression. Immunohistochemical analyses were performed to identify activated pathways in the resulting brain tumors. The effects of the MEK inhibitor U0126 on oncogenic KRAS were evaluated.We demonstrated that transient transgenic expression of KRAS(G12V) in putative neural stem and/or progenitor cells induced brain tumorigenesis. When expressed under the control of the krt5 gene promoter, KRAS(G12V) induced brain tumors in ventricular zones (VZ) at low frequency. The majority of other tumors were composed mostly of spindle and epithelioid cells, reminiscent of malignant peripheral nerve sheath tumors (MPNSTs). In contrast, when expressed under the control of the gfap gene promoter, KRAS(G12V) induced brain tumors in both VZs and brain parenchyma at higher frequency. Immunohistochemical analyses indicated prominent activation of the canonical RAS-RAF-ERK pathway, variable activation of the mTOR pathway, but no activation of the PI3K-AKT pathway. In a krt5-derived stable and inducible transgenic line, expression of oncogenic KRAS resulted in skin hyperplasia, and the MEK inhibitor U0126 effectively suppressed this pro-proliferative effects. In a gfap-derived stable and inducible line, expression of oncogenic KRAS led to significantly increased mitotic index in the spinal cord.Our studies demonstrate that zebrafish could be explored to study cellular origins and molecular mechanisms of brain tumorigenesis and could also be used as a platform for studying human oncogene function and for discovering oncogenic RAS inhibitors.