tbuckley/cabot-search huggingface dataset:
Electrophysiological Mechanisms of Spontaneous Termination of Sustained Monomorphic Reentrant Ventricular Tachycardia in the Canine Postinfarction Heart
Authors: Nabil El-Sherif, Hong Yin, Edward B. Caref, Mark Restivo
Journal: Circulation (1996)

Background The electrophysiological mechanisms of spontaneous termination of sustained monomorphic ventricular tachycardia (SMVT), in the postinfarction heart, generally considered secondary to a reentrant mechanism, have not been fully investigated. Method and Results Epicardial activation maps of spontaneous termination of 20 different episodes of SMVT (lasting 30 seconds to 10 minutes) from 8 dogs, 4 to 5 days after one-stage ligation of the left anterior descending coronary artery, were analyzed with the use of 254 bipolar electrode recordings with high density (2.5 to 2.8 mm between bipolar electrodes) in the ischemic zone. All ventricular tachycardias (VTs) were due to circus movement reentry with a characteristic figure-8 configuration. Termination always occurred when the two circulating wave fronts blocked in the central common pathway (CCP). Two basic mechanisms of spontaneous termination were observed: (1) In 15 episodes, acceleration of conduction occurred in parts of the reentrant circuit and was associated with slowing of conduction and finally conduction block in the CCP. Acceleration of conduction occurred in the last few cycles of VT both at the outer border of the arcs of functional conduction block in the “normal” myocardial zone and at the pivot points to the entrance to the CCP. When acceleration of conduction was compensated on a beat-to-beat basis by an equal degree of slowing in the CCP, there was no discernible change in the cycle length of the VT in the ECG. In some episodes, the termination of the original reentrant circuit was followed by the development of a different, slower reentrant pathway that lasted for one or a few cycles prior to termination. (2) In 5 VT episodes, the activation wave front in the CCP abruptly broke across a stable arc of functional conduction block, resulting in premature activation of the CCP and conduction block. Conclusions Distinct electrophysiological changes always preceded spontaneous termination of stable SMVT. The electrophysiological basis for acceleration of conduction in parts of the reentrant circuit during the last few beats prior to termination and of the abrupt reactivation across a stable arc of block remains to be determined.
Abstract 204: Molecular function of the RNA binding protein EWS in RNA processing
Authors: Bethsaida I. Nieves, Shuang Niu, Dedeepya Vaka, Julia Salzman, Patrick Brown, Alejandro I. Sweet-Cordero
Journal: Cancer Research (2012)

Abstract The Ewing Sarcoma (EWS) protein is a member of the FET family of RNA-binding proteins and is involved in chromosomal translocations that generate oncogenic fusion genes found in a variety of sarcomas. EWS has been recently reported to be involved in regulating transcription, pre-mRNA processing, translation and DNA repair. However, the precise physiological role of EWS in RNA processing remains largely unknown. Using cross-linking immunopercipitation coupled with high-throughput sequencing (CLIP-Seq), we identified the full complement of RNAs bound to EWS in Hela cells. Analysis of RNA binding by EWS revealed that the greatest increase in binding was to mRNAs coding for A-I editing enzymes ADAR1, ADARB1 and ADARB2. EWS also bound to non-coding RNAs (lncRNAs) NEAT1 and MALAT1. Interestingly, these lncRNAs localize to specific subnuclear structures and have been implicated in regulating RNA editing and RNA splicing respectively. We hypothesize that EWS could play a role in regulating the subnuclear localization of other proteins involved in editing and splicing by virtue of its association with NEAT1 and MALAT1. We also found that binding of EWS to pre-mRNAs influenced alternative splicing. Paired-end RNA-Seq of the transcriptome revealed that knock down of EWS resulted in the over expression of 116 genes and the down regulation of 68 genes, including EWS itself. Further analysis identified 16 alternatively spliced genes following EWS knock down across two independent RNA seq experiments. Of these genes, 6 were also shown to bind EWS by CLIP-seq. These genes include, CENPA, CSTF1, RBBP6, RAC1, FANC1 and ANAPC5. These studies highlight a potential role for EWS as a critical regulator of alternative splicing and A-I editing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 204. doi:1538-7445.AM2012-204
A generalized Mantel-Haenszel analysis of the regression of blood pressure on blood lead using NHANES II data.
Authors: J R Landis, K M Flegal
Journal: Environmental Health Perspectives (1988)

This paper proposes an alternative analysis of the statistically significant blood pressure/blood lead relationship reported for males, ages 12 to 74, based on data from the second National Health and Nutrition Examination Survey. Because of the substantial decline, both for blood lead levels and blood pressures, during the 4-year survey period, there is considerable interest in the extent to which this association can be attributed to concurrent secular trends. The statistical methods illustrate the use of a randomization model-based approach to testing the statistical significance of the partial correlation between blood lead level and diastolic blood pressure, adjusting for age, body mass index, and the 64 sampling sites. The resulting analyses confirm that the significant linear association between blood lead levels and diastolic blood pressures cannot be dismissed as a spurious association due to concurrent secular trends in the two variables across the 4-year survey period. In a conservative approach to this investigation, a randomization model-based test statistic, using the actual level of the natural log of blood lead and diastolic blood pressure, remained statistically significant at the 5% level, even when averaging the association across 478 subgroups formed by the cross-classification of age, body mass index, and the 64 sampling sites.
Let's CHAT about Adenotonsillectomy
Authors: Robert T. Brouillette
Journal: New England Journal of Medicine (2013)

Obstructive sleep apnea is common among children, with an estimated point prevalence of 1 to 5%.1 Important sequelae include cardiovascular, growth, cognitive, and behavioral deficits. Adenotonsillectomy, the usual first-line treatment, most often cures or ameliorates the disorder. Each year, 77% of the 530,000 tonsillectomies in the United States are performed for obstructive sleep apnea.2,3 Given 4 million births in the United States annually, approximately one in eight American children will eventually have their tonsils removed, thus suggesting a prevalence of obstructive sleep apnea during childhood as high as 10%. Despite the frequency and severity of pediatric obstructive sleep apnea, . . .
Anomalous pulmonary venous drainage shown by duplex sonography, computed tomography, and plain radiography.
Authors: P Huebsch, A Neuhold, H Mayr, D Glogar
Journal: Thorax (1989)

In a patient with the scimitar syndrome duplex Doppler sonography was used to show the point of entry of the abnormal pulmonary vein into the inferior vena cava to determine blood flow. Chest radiography and computed tomography also showed the vein descending to the diaphragm.
Short-chain acyl-coenzyme A dehydrogenase deficiency. Clinical and biochemical studies in two patients.
Authors: B A Amendt, C Greene, L Sweetman, J Cloherty, V Shih, A Moon, L Teel, W J Rhead
Journal: Journal of Clinical Investigation (1987)

We describe two patients with short-chain acyl-coenzyme A (CoA) dehydrogenase (SCADH) deficiency. Neonate I excreted large amounts of ethylmalonate and methylsuccinate; ethylmalonate excretion increased after a medium-chain triglyceride load. Neonate II died postnatally and excreted ethylmalonate, butyrate, 3-hydroxybutyrate, adipate, and lactate. Both neonates' fibroblasts catabolized [1-14C]butyrate poorly (29-64% of control). Neonate I had moderately decreased [1-14C]octanoate catabolism (43-60% of control), while neonate II oxidized this substrate normally; both catabolized radiolabeled palmitate, succinate, and/or leucine normally. Cell sonicates from neonates I and II dehydrogenated [2,3-3H]butyryl-CoA poorly (41 and 53% of control) and [2,3-3H]octanoyl-CoA more effectively (59 and 95% of control). Mitochondrial acyl-CoA dehydrogenase (ADH) activities with butyryl- and octanoyl-CoAs were 37 and 56% of control in neonate I, and 47 and 81% of control in neonate II, respectively. Monospecific medium-chain ADH (MCADH) antisera inhibited MCADH activity towards both butyryl- and octanoyl-CoAs, revealing SCADH activities to be 1 and 11% of control for neonates I and II, respectively. Fibroblast SCADH and MCADH activities were normal in an adult female with muscular SCADH deficiency.
On Cases of Cerebral Tumour and Other Forms of Brain-Disease, with Special Reference to the Doctrine of Localisation
Authors: T. R. Glynn
Journal: BMJ (1878)

it71tcoutdpition remains some ticme without my other bad syptom1 the addition of a small quantity of watery extract of aloes to the above drugs; in others, small doses of sulpbate of magnesia frequently re- peated, have proved most effective, either being at once stopped on the return-of any acute symptom.By these means, most of my cases of obstruction have bad a favour.able termination.In those which have unhappily terminated fatally, the pdst mortem examinations have shown that abdominal taxis under ether (which I have never employed, although probably of the greatest use in exceptional cases) would have been useless, and that no further relief would have been possible, except by opening either the colon or the small bowel by operation.In another paper, I hope to be able to give an analysis of a number of cases, also a new mode by which, I believe, obstruction of the colon may be more accurately diagnosed.
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis
Authors: Pilar Esteve, Africa Sandonìs, Marcos Cardozo, Jordi Malapeira, Carmen Ibañez, Inmaculada Crespo, Severine Marcos, Sara Gonzalez-Garcia, Maria Luisa Toribio, Joaquin Arribas, Akihiko Shimono, Isabel Guerrero, Paola Bovolenta
Journal: Nature Neuroscience (2011)
Abstract 652: Reproductive and hormonal factors and ovarian cancer: Case-control study
Authors: Seunghyun ma, Sue K. Park, Keun-Young Yoo, Tae Joong Kim, Byoung-Gie Kim, Yong-Man Kim, Jae Weon Kim
Journal: Cancer Research (2012)

Abstract Backgrounds: Menstrual, reproductive and hormonal factors have been related to ovarian cancer risk, but further quantification of their role in various populations is required. Patients and methods: Cases were 77 women, below age 79, with incident, histologically confirmed epithelial ovarian cancer, and 117 women with, histologically confirmed benign ovarian tumor and controls 776 women, age matched controls The study was conducted from 2009 to 2010 in five hospitals in Seoul, South Korea. Data were obtained through in-person interviews and analysis was conducted using unconditional logistic regression Results: A statistically significant inverse association was observed between parity and ovarian cancer risk and between parity and benign ovarian tumor (Odds ratio [OR] = 0.18; 95% confidence interval [CI] = 0.06-0.50, OR=0.08, CI (0.02-0.30))No consistent association was observed with time since first or last birth, nor with spontaneous or induced abortions Breastfeeding was associated with a significant reduction in risk of ovarian cancer and benign neoplasm. (OR=0.33, CI (0.17-0.68), OR=0.42 CI(0.34-0.94)) Conclusion: This uniquely asian study confirms and further quantities the relation between hormonal and reproductive factors and ovarian cancer.The pattern of risk observed cannot be totally explained by a role of ovulation in ovarian carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 652. doi:1538-7445.AM2012-652
Predictors of progression of liver disease in chronic hepatitis C patients with minimal fibrosis: kinetic of serum tumor necrosis factor and transforming growth factor serum levels
Authors: Manuela Neuman, Izabella Malkiewicz, Jean-Pierre Benhamou, Dominique Valla, Michelle Martinot-Peignoux, Raoudha Akremi, Tarik Asselah, Patrick Marcellin
Journal: Journal of Hepatology (2002)
Electrocardiographic effects of experimental nontransmural myocardial infarction.
Authors: D M Mirvis, L Ingram, M K Holly, J L Wilson, K B Ramanathan
Journal: Circulation (1985)

Clinical and experimental data have documented the ability of nontransmural myocardial infarction to produce abnormal Q waves on both the epicardial and body surfaces. We undertook this study to define the anatomic determinants of such Q wave development. Thirty dogs were studied before and after occlusion-reperfusion (26 dogs) or latex embolization (four dogs) of the left circumflex coronary artery. Occlusion was maintained for 60 to 240 min before reperfusion to produce nontransmural lesions of various sizes. Electrocardiographic data were registered from 84 torso electrodes by body surface mapping techniques before and 1 week after infarction. Infarct size was quantitated by computer analysis of heart slices stained with triphenyl tetrazolium chloride. Six dogs did not develop infarction. Of the remaining 24, 10 did and 14 did not develop significant changes in body surface Q wave duration and width. The incidence of Q wave changes was not different in dogs with nontransmural and those with transmural lesions. Infarct size (expressed as a percentage of the left ventricle infarcted), the percentage of endocardium subjacent to infarction, the average depth of necrosis, the percent of the four outer fifths of the ventricular wall infarcted, and the duration of occlusion were significantly (p less than .05) greater in dogs with than in those without Q wave changes. Logistic regression modeling demonstrated that only two anatomic parameters--percentage of left ventricle infarcted and average lesion depth--significantly and independently predicted Q wave development. A model including only these two variables accurately classified all 24 cases.(ABSTRACT TRUNCATED AT 250 WORDS)
Late recurrence of thrombotic thrombocytopenic purpura after splenectomy.
Authors: D J Howard, A B Roberts, F T Page
Journal: BMJ (1975)

The second patient was investigated by his G.P. at the age of 34 in 1952.He had been married for 14 vears with no children.A phvsical examination was normal, as was his sexual function.No abnormalities had been found when his wife was investigated in 1946.In 1968 he was referred from his G.P. with a three-week history of diarrhoea.Faecal fats were 22 g/dy, and jejunal biopsy showed subtotal villous atrophv.He was diagnosed as having coeliac disease and started on a gluten-free diet.In 1973 a repeat jejunal biopsy showed normal histology.
Pneumatic Rupture of the Colon
Authors: J. C. Comline
Journal: BMJ (1952)

FIFE MEDIIplained of pain in the back of the neck as well as subcostal pain.Movement of the trunk and waiking increased the pain in several cases.The pain was accompanied by sick- ness and vomiting in only two cases, and only one com- plained of constipation.Four patients had sore throat and nine had headache.All but three had a rise in temperature, the range being from 99 to 1020 F. (37.2 to 38.90 C.).Upper abdominal tenderness was present in nine, being in the right subcostal region in five.One patient had pain at the right shoulder-tip on deep palpation in the right hypochondrium.Tenderness over the lower thorax was' noted in one case.Apart from these signs no other abnormality was noted on abdominal examination.Examination of the chest at the onset of the illness revealed no definite abnormality except restricted breathing and occa- sionally inverse breathing.In five cases pleural friction was noted four to ten days after the onset (Table II).One patient TABLE II.-Cases with Pleural Friction
Acute Primary HIV-Esophagitis
Authors: J. F. W. M. Bartelsman, J. M. A. Lange, R. van Leeuwen, J. G. van den Tweel, G. N. J. Tytgat
Journal: Endoscopy (1990)

We report on a case of acute primary HIV-esophagitis in a 29-year-old man, who presented with fever, diarrhea, odynophagia and a skin rash. Endoscopy of the esophagus revealed multiple small shallow ulcerations. HIV-I p24 antigen could only be shown in the blood on the day of admission to hospital, 7 days after the acute onset on the disease. Seroconversion for HIV-I antibodies took place 2 days after the onset.
Use of Tape-Recorded Heart Sounds in Screening of Children for Heart Disease
Authors: JACQUES M. SMITH, ROBERT A. MILLER, CARL MARIENFELD, BETTY HAHNEMAN, JOEL WILLARD
Journal: Circulation (1959)

An automated tape-recording unit for use in screening large populations of school children for heart disease has been developed and field tested. A technician can produce good quality apex and base heart sound recordings from 250 children during an average school day. The physician can listen to these recordings at a rate of 140 children per hour, recalling for examination each child considered to have an abnormal recording. Since almost all heart disease in children has some acoustic manifestation, a screening technic based on the heart sounds seems to be a logical one. The studies done with this unit have demonstrated its ability to select children with heart disease from a large number of normal children. Agreement between readers is satisfactory, and the number of "false positives" is considered reasonable.
The Clinical Interview for Depression: A Comprehensive Review of Studies and Clinimetric Properties
Authors: Jenny Guidi, Giovanni A. Fava, Per Bech, Eugene Paykel
Journal: Psychotherapy and Psychosomatics (2010)

&lt;i&gt;Background:&lt;/i&gt; A comprehensive assessment of the wide spectrum of depressive symptomatology, particularly in its subclinical forms, is lacking in standard rating scales. There is also an emerging need for instruments that can detect small differences in therapeutic studies and have good sensitivity. The purpose of this paper is to review the clinimetric characteristics of Paykel’s Clinical Interview for Depression (CID) and to examine the results of the studies in which the interview has been used. &lt;i&gt;Methods:&lt;/i&gt; Published reports which involved the use of the CID were identified by searching the following electronic databases: Medline, PsychINFO, EMBASE, and Web of Science. A manual search of the literature was also performed. &lt;i&gt;Results:&lt;/i&gt; The initial strategies yielded 169 published reports for potential inclusion in the review: 98 are discussed here. The CID has been used extensively in a variety of studies, including descriptive studies, classification by means of factor analysis and cluster analysis, and predictor variables of response to treatment or relapse. The CID has also been used as an outcome measure in several controlled clinical trials and follow-up studies of pharmacotherapy and psychotherapy of affective disorders. It has been shown to be valid and reliable, to discriminate depressives from controls, or different subgroups of depressed patients, and to reflect changes during the course of treatment, particularly when individual symptoms are considered. &lt;i&gt;Conclusions:&lt;/i&gt; Evidence from these studies highlights the utility of the CID in clinical research and practice. Its clinimetric characteristics, particularly the broad evaluation of affective symptomatology and the sensitivity to change, make it an instrument of choice in therapeutic trials.
Self-expandable metal stents as a new treatment option for perforated duodenal ulcer
Authors: M. Bergström, J. Vázquez, P.-O. Park
Journal: Endoscopy (2012)

Primary stenting and drainage has been shown to be an effective and safe way to treat esophageal perforations and anastomotic leaks after gastric bypass surgery. We present a case series of eight patients with perforated duodenal ulcers treated with covered self-expandable metal stents (SEMS). The first two patients received their stents because of postoperative leakage after initial traditional surgical closure. The following six patients had SEMS placed as primary treatment due to co-morbidities or technical surgical difficulties. Endoscopy and stent treatment in these six patients was performed at a median of 3 days (range, 0 – 7 days) after initial symptoms. Six patients had percutaneous abdominal drainage. Early oral intake, 0 – 7 days after stent placement, was possible. All patients except one recovered without complications and were discharged 9 – 36 days after stent placement. This series indicates that primary treatment with SEMS and drainage might be an alternative to surgery in patients with perforated ulcer disease.
A Prospective, Blinded Comparison of Magnetic Resonance (MR) Imaging–Ultrasound Fusion and Visual Estimation in the Performance of MR-targeted Prostate Biopsy: The PROFUS Trial
Authors: James S. Wysock, Andrew B. Rosenkrantz, William C. Huang, Michael D. Stifelman, Herbert Lepor, Fang-Ming Deng, Jonathan Melamed, Samir S. Taneja
Journal: European Urology (2013)
METABOLISM AND FUNCTION OF GAMMA GLOBULIN IN ALEUTIAN DISEASE OF MINK
Authors: David D. Porter, Frank J. Dixon, Austin E. Larsen
Journal: The Journal of Experimental Medicine (1965)

Aleutian disease-affected mink, which are markedly hypergammaglobulinemic, show a decreased half-life of the serum gamma globulin indicating that the hyperglobulinemia is due to increased production. No evidence that the gamma globulin was antibody to the infectious agent, to autologous or isologous tissues, or to antigens the animal was responding to prior to development of the disease was obtained. The increased gamma globulin was found to be of the 6.4S variety, and gamma globulin containing protein-protein complexes of 9S to 17S and 22S to 25S classes were observed in serums of affected mink. The findings are most consistent with the Aleutian disease virus acting as a direct and somewhat selective stimulus to plasma cell proliferation. There is no evidence that the arterial and glomerular lesions of Aleutian disease have an immunologic pathogenesis. It seems possible that these vascular changes may be directly caused by the viral agent, or may be the result of the increased gamma globulin levels.