tbuckley/cabot-search huggingface dataset:
Effects of Motive-Oriented Therapeutic Relationship in a Ten-Session General Psychiatric Treatment of Borderline Personality Disorder: A Randomized Controlled Trial
Authors: Ueli Kramer, Stéphane Kolly, Laurent Berthoud, Sabine Keller, Martin Preisig, Franz Caspar, Thomas Berger, Yves de Roten, Pierre Marquet, Jean-Nicolas Despland
Journal: Psychotherapy and Psychosomatics (2014)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Motive-oriented therapeutic relationship (MOTR) was postulated to be a particularly helpful therapeutic ingredient in the early treatment phase of patients with personality disorders, in particular with borderline personality disorder (BPD). The present randomized controlled study using an add-on design is the first study to test this assumption in a 10-session general psychiatric treatment with patients presenting with BPD on symptom reduction and therapeutic alliance. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; A total of 85 patients were randomized. They were either allocated to a manual-based short variant of the general psychiatric management (GPM) treatment (in 10 sessions) or to the same treatment where MOTR was deliberately added to the treatment. Treatment attrition and integrity analyses yielded satisfactory results. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; The results of the intent-to-treat analyses suggested a global efficacy of MOTR, in the sense of an additional reduction of general problems, i.e. symptoms, interpersonal and social problems (F&lt;sub&gt;1, 73&lt;/sub&gt; = 7.25, p &lt; 0.05). However, they also showed that MOTR did not yield an additional reduction of specific borderline symptoms. It was also shown that a stronger therapeutic alliance, as assessed by the therapist, developed in MOTR treatments compared to GPM (Z&lt;sub&gt;55&lt;/sub&gt; = 0.99, p &lt; 0.04). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; These results suggest that adding MOTR to psychiatric and psychotherapeutic treatments of BPD is promising. Moreover, the findings shed additional light on the perspective of shortening treatments for patients presenting with BPD.
The therapeutic efficiency of FP-PEA/TAM67 gene complexes via folate receptor-mediated endocytosis in a xenograft mice model
Authors: Rohidas B. Arote, Soon-Kyung Hwang, Hwang-Tae Lim, Tae-Hee Kim, Dhananjay Jere, Hu-Lin Jiang, You-Kyoung Kim, Myung-Haing Cho, Chong-Su Cho
Journal: Biomaterials (2009)
Antibody Response to Cannabis
Authors: Charles M. Shapiro
Journal: JAMA (1974)

Cannabis metabolites are antigenic and capable of eliciting an immune response. With the indirect Coombs test, humoral antibodies were found in 15 of 17 subjects who were habitual smokers of the plant. The relationship of cannabis-induced antibody formation to clinical disease was not determined. (<i>JAMA</i>230:81-82, 1974)
Massive plasmocytosis due to methimazole‐induced bone marrow toxicity
Authors: D.V. Breier, P. Rendo, J. Gonzalez, G. Shilton, M. Stivel, S. Goldztein
Journal: American Journal of Hematology (2001)

Pancytopenia is a rare complication of the thionamide therapy reported secondary to aplastic anemia, the bone marrow being invariably hypocellular. We present a case of a 16-year-old female with Graves' disease who presented with massive bone marrow plasmocytosis mimicking multiple myeloma. The patient had already been on methimazole for a month when she was admitted to the Pediatric Unit with the diagnosis of sepsis. CBC revealed pancytopenia. Bone marrow aspirations showed hypocellular-normocellular bone marrow, 98% of plasma cells. At that time, MMI was discontinued and the patient was started on broad-spectrum antibiotics, dexamethasone, and G-CSF. Bone marrow aspiration day +4 still showed hypo-normocellular marrow, with remaining 6% plasma cells. Myeloma screen was negative; ANC >1,000 at day +7, platelets >50,000 at day +24. Twenty-four months after patient's discharge, her clinical condition, CBC, and bone marrow remained normal. To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.
Periodic screening with prostate-specific antigen testing reduced mortality from prostate cancer
Authors: Steven E. Canfield
Journal: Annals of Internal Medicine (2009)

ACP Journal Club16 June 2009Periodic screening with prostate-specific antigen testing reduced mortality from prostate cancerSteven E. Canfield, MDSteven E. Canfield, MDUniversity of Texas Medical School at Houston, Houston, Texas, USA (S.E.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-12-200906160-02005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSchröder FH, Hugosson J, Roobol MJ, et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009;360:1320-8. https://pubmed.ncbi.nlm.nih.gov/19297566Clinical Impact RatingsGIM/FP/GP: Oncology: References1 Thompson IM, Pauler DK, Goodman PJ, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level ≤ 4.0 ng per milliliter. N Engl J Med. 2004;350:2239-46. [PMID: 15163773] Google Scholar2 Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71-96. [PMID: 18287387] Google Scholar3 Johansson JE, Andrén O, Andersson SO, et al. Natural history of early, localized prostate cancer. JAMA. 2004;291:2713-9. [PMID: 15187052] Google Scholar4 Draisma G, Boer R, Otto SJ, et al. Lead times and overdetection due to prostate-specific antigen screening: estimates from the European Randomized Study of Screening for Prostate Cancer. J Natl Cancer Inst. 2003;95:868-78. [PMID: 12813170] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Medical School at Houston, Houston, Texas, USA (S.E.C.)This article was published at Annals.org on 2 June 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAnnual screening for prostate cancer did not reduce mortality from prostate cancer Steven E. Canfield Metrics 16 June 2009Volume 150, Issue 12Page: JC6-5KeywordsAntigensCancer preventionCancer screeningCancer treatmentDeath ratesForecastingLikelihood ratioMortalityProstate cancerRelative risk ePublished: 16 June 2009 Issue Published: 16 June 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A green humidifier chamber
Authors: J. Tolson, P. Rochford, C. Worsnop
Journal: European Respiratory Journal (2008)

may be too low [9, 10], assaying the ex vivo reactivity of bronchoalveolar lavage T-cells towards Mycobacterium tuberculosis-specific antigens by flow cytometry may further improve the diagnostic accuracy of on-site immune based assays for the diagnosis of smear-negative tuberculosis.
THE TREATMENT OF FRACTURES
Authors: G. A. Wright
Journal: BMJ (1907)

Autoreactive CD4+ T cells exist in normal individuals and retain the capacity to initiate autoimmune disease. The current study investigates the role of CD4+CD25+ T-regulatory (TR) cells during autoimmune disease using the CD4+ T cell-dependent myelin oligodendrocyte glycoprotein (MOG)-specific experimental autoimmune encephalomyelitis model of multiple sclerosis. In vitro, TR cells effectively inhibited both the proliferation of and cytokine production by MOG35–55-specific Th1 cells. In vivo, adoptive transfer of TR cells conferred significant protection from clinical experimental autoimmune encephalomyelitis which was associated with normal activation of autoreactive Th1 cells, but an increased frequency of MOG35–55-specific Th2 cells and decreased CNS infiltration. Lastly, transferred TR cells displayed an enhanced ability to traffic to the peripheral lymph nodes and expressed increased levels of the adhesion molecules ICAM-1 and P-selectin that may promote functional interactions with target T cells. Collectively, these findings suggest that TR cells contribute notably to the endogenous mechanisms that regulate actively induced autoimmune disease.
931 HEPATIC MITOCHONDRIA OBTAINED FROM 6-OHDA-LESIONED PARKINSONIAN RATS EXHIBIT DECREASED ENERGY CAPACITY AND MEMBRANE POTENTIAL
Authors: M. Vairetti, A. Ferrigno, V. Rizzo, G. Ambrosi, A. Bianchi, P. Richelmi, F. Blandini, M.T. Armentero
Journal: Journal of Hepatology (2010)
Rheological determinants in patients with Gaucher disease and internal inflammation
Authors: Ari Zimran, Amir Bashkin, Deborah Elstein, Bernard Rudensky, Rivka Rotstein, Meirav Rozenblat, Tamar Mardi, David Zeltser, Varda Deutsch, Itzhak Shapira, Shlomo Berliner
Journal: American Journal of Hematology (2004)

The purpose of this study was to determine whether the inflammatory response in patients with Gaucher disease (GD) is accompanied by enhanced adhesiveness/aggregation of both red and white blood cells. Sixty patients with GD and matched controls were included. The degree of erythrocyte and leukocyte adhesiveness/aggregation was determined by using a simple slide test and image analysis. Patients with GD had significantly elevated concentrations of fibrinogen (328 vs. 262 mg/dl, P < 0.0001) and accelerated erythrocyte sedimentation rates (27 vs. 13 mm/H, P < 0.005). This was accompanied by a significantly enhanced degree of erythrocyte (75 vs. 85, P < 0.0001) and leukocyte (3.5 vs. 1.3, P < 0.002) adhesiveness/aggregation. The low-grade, smoldering, and subclinical internal inflammation in individuals with GD is accompanied by an increased degree of erythrocyte and leukocyte adhesiveness/aggregation. These findings might have rheological consequences in terms of microcirculatory slow flow and tissue hypoxemia.
Evidence of a "Silent" Bacillemia in Primary Tuberculosis
Authors: WILLIAM W. STEAD
Journal: Annals of Internal Medicine (1971)

A case is described in which a chest-wall abscess appears to have developed during the course of a silent primary tuberculous infection caused by localization of bacilli in the site of blunt trauma. This demonstration of the occurrence of bacillemia in the course of primary tuberculosis in man adds credibility to the "unitary concept" of the pathogenesis of tuberculosis in man.
Anticoagulation Therapy in Atrial Fibrillation in Combination With Acute Myocardial Infarction Influences Long-Term Outcome
Authors: Ulf Stenestrand, Johan Lindbäck, Lars Wallentin
Journal: Circulation (2005)

The American and European guidelines do not agree with regard to antithrombotic treatment in patients with atrial fibrillation (AF) and acute myocardial infarction (AMI), thus causing uncertainty among physicians. We investigated the prescription of oral anticoagulation (OAC) in patients discharged alive with AF after an AMI and the influence of OAC treatment on 1-year mortality.This was a prospective cohort study using data from the Register of Information and Knowledge about Swedish Heart Intensive care Admissions (RIKS-HIA) on patients admitted to the coronary care units of 72 Swedish hospitals from 1995 to 2002. A total of 6182 patients discharged alive with first registry-recorded AMI and AF on discharge ECG were included. One-year mortality data were obtained from the Swedish National Cause of Death Register. Only 30% (n=1848) of the 6182 patients with AF were prescribed OAC. At 1 year, the unadjusted mortality was 31% (1183 deaths) in the platelet-inhibitors only group and 22% (414 deaths) in the OAC-treated group. In Cox regression analysis with adjustment for confounding factors, OAC treatment was associated with a reduction in 1-year mortality (relative risk 0.73; 95% CI 0.62 to 0.86; P<0.001) in hospital survivors of AMI with AF. The reduction in mortality appeared to be caused primarily by a lower rate of ischemic heart death (55.6% versus 62.0%) and fatal stroke (5.7% versus 7.5%) in the OAC group. This reduction of mortality was similar among most subgroups based on age, sex, baseline characteristics, previous disease manifestations, and medications.In daily clinical practice, OAC was only given to a minority (30%) of AMI patients with AF, despite the fact that OAC was associated with a 29% relative and 7% absolute reduction in 1-year mortality after adjustment for confounding variables. The results emphasize the importance of OAC treatment for AF after AMI.
Abstract 1935: Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients and is different in gender.
Authors: Thomas Greither, Franziska Koser, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Steffen Goebel, Hans-Jürgen Holzhausen, Sven Wach, Peter Würl, Helge W. Taubert
Journal: Cancer Research (2013)

Abstract The family of Argonaute genes is essential for stem cell maintenance and RNA interference. Piwi-like genes as a subclass of the Argonaute genes are expressed mainly in the germline. However, these genes may be re-expressed in tumors, and expression of the Piwi-like genes is associated with prognosis in several types of tumors. We analyzed the expression of Piwi-like mRNAs (Piwi-like 2-4) in 125 soft tissue sarcoma (STS) samples by qPCRs. Statistical tests were applied to study the correlation of expression levels with tumor-specific survival for STS patients. In multivariate Cox's regression analyses, we detected that low Piwi-like 2 and Piwi-like 4 mRNA expression were significantly associated with a worse prognosis (RR = 1.87; p = 0.032 and RR = 1.82; p = 0.039). In addition, low expression of both genes was associated with a 2.58-fold increased risk of tumor-related death (p = 0.01). Next we analysed expression of Piwi-like genes gender specific. Piwi-like 4 and combined Piwi-like 2 and 4 mRNA levels correlated significantly with prognosis (RR = 3.53; p = 0.002 and RR = 5.23; p = 0.004) only for female but not for male patients. However, combined low Piwi-like 2 and 3 transcript levels were associated with worse survival (RR = 5.90; p = 0.02) for male patients. In this study, we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients. A connection between gender and the impact of Piwi-like mRNA expressions on STS patients’ prognosis was shown for the first time. Citation Format: Thomas Greither, Franziska Koser, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Steffen Goebel, Hans-Jürgen Holzhausen, Sven Wach, Peter Würl, Helge W. Taubert. Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients and is different in gender. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1935. doi:10.1158/1538-7445.AM2013-1935
Rural-Urban Differences in Access to Specialist Providers of Colorectal Cancer Care in the United States
Authors: Jonathan K. Aboagye, Heather E. Kaiser, Awori J. Hayanga
Journal: JAMA Surgery (2014)

Although early detection and treatment of colorectal cancer has been shown to improve outcomes, geographic proximity may influence access to these services.To examine the disparities that may exist in colorectal cancer screening and treatment by comparing the distribution of providers of these services in rural and urban counties in the United States.A retrospective population-based study using data obtained from the 2009 Area Resource File for the entire US population within each county.Counties in the United States were categorized as rural or urban using rural-urban continuum codes as our primary exposure. The proportion of gastroenterologists, general surgeons, and radiation oncologists per 100,000 people in each county was estimated as primary outcomes. Multivariate linear regression analysis adjusted for county-level socioeconomic variables, such as percentages of females, blacks, population without insurance, those with a high school diploma, and median household income, to estimate the relative density of each category of these providers between urban and rural counties.In total, 3220 counties were identified, comprising 1807 rural and 1413 urban counties. An unadjusted analysis showed an increased density of gastroenterologists, general surgeons, and radiation oncologists per 100,000 people in urban vs rural counties. A multivariable analysis revealed a significantly higher density of gastroenterologists (1.63; 95% CI, 1.40-1.85; P < .001), general surgeons (2.01; 95% CI, 1.28-2.73; P < .001), and radiation oncologists (0.68; 95% CI, 0.59-0.77; P < .001) per 100,000 people living in urban vs rural counties.A rural-urban disparity exists in the density of gastroenterologists, general surgeons, and radiation oncologists who traditionally provide colorectal cancer screening services and treatment. This might affect access to these services and may negatively influence outcomes for colorectal cancer in rural areas.
Experimental right ventricular hypertrophy and failure in swine
Authors: K. C. WELHAM, E. D. SILOVE, R. K. H. WYSE
Journal: Cardiovascular Research (1978)

Following pulmonary arterial constriction, 22 pigs developed right ventricular failure and 10 right ventricular hypertrophy. Comparing results with those obtained in 21 normal pigs (no pulmonary artery constriction), it was found the right ventricular peak systolic and end-diastolic pressures, cardiac output, and right ventricular weight distinguished hypertrophied and failing hearts from normal ones. Cardiac output was lower in failing hearts than in hypertrophied hearts and was the only variable which significantly differentiated between these two groups. Left ventricular pressures and left ventricular and right ventricular dP/dtmax, and maximum [(dP/dt) / P] did not distinguish failing from hypertrophied hearts. Left ventricular pressure, maximum [(dP/dt) / P] and left ventricular and right ventricular dP/dtmax were not significantly different in the three groups.
Uncurl those lips
Authors: I. Robertson
Journal: BMJ (1995)

Those who believe the French scientists' claim that the Murorua explosion is perfectly safe should have a word with the citizens of Caithness in Scotland, whose fast breeder nuclear reactor programme spewed out lumps of radioactive waste to the extent that the beaches near Dounreay had to be closed. Scientists in both France and Caithness offered reassurances about the safety of their schemes—often in the tones of weary patronage so beloved of scientists talking to their public. When it comes to knowing which side their bread is buttered, however, scientists are no different from the rest of the population: it's hard to face up to …
Chemical and toxicological characterization of residential oil burner emissions: I. Yields and chemical characterization of extractables from combustion of No. 2 fuel oil at different Bacharach Smoke Numbers and firing cycles.
Authors: J A Leary, K Biemann, A L Lafleur, E L Kruzel, G P Prado, J P Longwell, W A Peters
Journal: Environmental Health Perspectives (1987)

Particulates and complex organic mixtures were sampled from the exhaust of a flame retention head residential oil burner combusting No. 2 fuel oil at three firing conditions: continuous at Bacharach Smoke No. 1, and cyclic (5 min on, 10 min off) at Smoke Nos. 1 and 5. The complex mixtures were recovered by successive Soxhlet extraction of filtered particulates and XAD-2 sorbent resin with methylene chloride (DCM) and then methanol (MeOH). Bacterial mutagenicity [see Paper II (8)] was found in the DCM extractables. Samples of DCM extracts from the two cyclic firing conditions and of the raw fuel were separated by gravity column chromatography on alumina. The resulting fractions were further characterized by a range of instrumental methods. Average yields of both unextracted particulates and of DCM extractables, normalized to a basis of per unit weight of fuel fired, were lower for continuous firing than for cyclic firing. For cyclic firing, decreasing the smoke number lowered the particulates emissions but only slightly reduced the average yield of DCM extractables. These and similar observations, here reported for two other oil burners, show that adjusting the burner to a lower smoke number has little effect on, or may actually increase, emissions of organic extractables of potential public health interest. Modifications of the burner firing cycle aimed at approaching continuous operation offer promise for reducing the amount of complex organic emissions. Unburned fuel accounted for roughly half of the DCM extractables from cyclic firing of the flame retention head burner at high and low smoke number. Large (i.e., greater than 3 ring) polycyclic aromatic hydrocarbons (PAH) were not observed in the DCM extractables from cyclic firing. However, nitroaromatics, typified by alkylated nitronaphthalenes, alkyl-nitrobiphenyls, and alkyl-nitrophenanthrenes were found in a minor subfraction containing a significant portion of the total mutagenic activity of the cyclic low smoke samples (8). Oxygen-containing PAH, typified by phenalene-1-one and its alkyl derivatives, are important mutagens from cyclic firing at high smoke conditions. Thus, oil burner effluents differ markedly from those of several other combustors, including the automotive diesel engine, where multiring PAH, typified by fluoranthene and alkylated phenanthrenes, account for a significant portion of the effluent mutagenicity. Implications for combustion and emissions source identification are discussed.
A Two-Year Experience With a Series of Rural Skin and Oral Cancer Detection Clinics
Authors: Peyton E. Weary
Journal: JAMA (1971)

Farmers and ranchers are more prone to develop skin cancer as an occupational hazard. In order to promote early detection of premalignant and malignant skin lesions a number of skin and oral cancer detection clinics were held in rural communities in central Virginia. The results of these clinics were very gratifying with an overall detection rate of 21.6% premalignant or malignant lesions in the population examined.
IgE Synthesis <i>in vitro</i>: Attempt to Isolate Stimulating Factors
Authors: B. De La Parra, N. Vulliet, J.‐P. Girard
Journal: Allergy (1986)

Studies made in our laboratory have demonstrated the presence in atopic serum of enhancing factors(s) for in vitro IgE synthesis by peripheral blood lymphocytes (BPL). Here we show that these enhancing factors can be recovered from human serum by means of immunoabsorbents. This factor is able to stimulate in vitro IgE synthesis by PBL independent of presence of IgE.
Epidemiology and clinical impact of hepatitis D virus (delta) infection
Authors: Ira M. Jacobson, Jules L. Dienstag, Barbara G. Werner, Doreen B. Brettler, Peter H. Levine, Isa K. Mushahwar
Journal: Hepatology (1985)

We tested sera collected between 1976 and 1984 from 362 persons in a variety of epidemiologic categories with acute and chronic hepatitis B and from 76 hemophiliacs and drug addicts with hepatitis B antibodies for hepatitis D markers. Hepatitis D markers were common in hemophiliacs, drug addicts, Afghanistanis, prisoners and hemodialysis patients; rare in persons from other hepatitis–B endemic areas, persons with sporadic hepatitis B and homosexual men; and absent in health–care workers and institutionalized mentally retarded persons. No change was observed in the frequency of this infection during the 9 years of this study. We found hepatitis D markers in 5% of patients with acute hepatitis B, 1 of 3 with fulminant hepatitis and in 4 (1 in a homosexual male) of 12 episodes of acute hepatitis in hepatitis B carriers. Hepatitis D markers were more frequent in chronic liver disease (18%) than in asymptomatic hepatitis B carriage (2%), but there was no association between severity of chronic hepatitis and hepatitis D. These findings indicate that, to date, health–care workers and institutionalized mentally retarded persons have been spared from infection with this agent but suggest that homosexual males may not continue to be spared. Even in an area nonendemic for hepatitis D, this agent contributed to 20 to 30% of chronic hepatitis B and acute hepatitis superimposed on chronic hepatitis B infection.