tbuckley/cabot-search huggingface dataset:
Physician's Guide to Drug Eruptions
Authors: Howard Kurshenbaum
Journal: Annals of Internal Medicine (1998)

Medical Writings15 September 1998Physician's Guide to Drug EruptionsHoward Kurshenbaum, MDHoward Kurshenbaum, MDKaiser Permanente, La Mesa, CaliforniaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-6-199809150-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Physician's Guide to Drug Eruptions; Litt JZ. 261 pages. New York: Parthenon; 1998. $68.00. ISBN 1850700036. Order phone 800-735-4744.Field of medicine: Dermatology.Format: Softcover book.Audience: Dermatologists and primary care physicians.Purpose: To serve as an easy-to-use reference on cutaneous side effects of more than 250 common prescription and nonprescription medications.Content: This guide is a state-of-the-art reference on common adverse skin reactions. It starts with a thorough list of generic and trade names of common medications, which are detailed in the body of the book. The major section is an easy-to-use alphabetic guide that provides generic names of ... Author, Article, and Disclosure InformationAffiliations: Kaiser Permanente, La Mesa, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCorrection: Book Note 15 September 1998Volume 129, Issue 6Page: 511KeywordsAdverse reactionsDermatologyDrug interactionsDrugsPrimary care physiciansSkin reaction ePublished: 15 August 2000 Issue Published: 15 September 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ESGE Newsletter2<sup>nd</sup> European Symposium on Ethics in Gastroenterology and Digestive EndoscopyKos, Greece, 6 - 8 July, 2006
Authors: S. Ladas, C. Stanciu
Journal: Endoscopy (2006)

The members of the Organizing Committee of the 2nd European Symposium on Ethics in Gastroenterology and Digestive Endoscopy are grateful to all their colleagues who contributed to making this meeting as successful as the first symposium, which was held 4 years ago. The meeting was organized by the European Society of Gastrointestinal Endoscopy (ESGE) and the World Organization for Gastrointestinal Endoscopy (OMED), in association with the United European Gastroenterology Federation (UEGF), and was held on the island of Kos, the home of Hippocrates, which provided an appropriate historical atmosphere for such a scientific event.
759. Liver Transduction with an SV40 Vector Encoding Insulin-Like Growth Factor I Reduces Hepatic Damage and Delays Cirrhosis Progression
Authors: Maria Vera, Laura Martinez, Mikel Zaratiegui, Carlos Rodriguez, Jesus Prieto, Puri Fortes
Journal: Molecular Therapy (2005)

Top of pageAbstract
Circulating insulin-like growth factor I (IGF-I) is mainly of hepatic origin and its levels are markedly decreased in liver cirrhosis. Treatment with IGF-I displays hepatoprotective properties and improves nutrition and hypogonadism in experimental cirrhosis. In this study we analyzed the efficacy of a Simian Virus 40 (SV40)-based vector encoding IGF-I to treat rats subjected to CCl4 inhalation. Recombinant SV40 vectors (rSV40) efficiently infect hepatocytes where they drive durable transgene expression. In this study we found that luciferase expression in rSV40-infected mouse livers can be detected with a CCD camera for more than seven months. Even if expression from rSV40 is low, hepatic luciferase activity significantly increased after induction of liver damage with CCl4. Luciferase levels also increased in response to IGF-I administration, thus favouring transgene expression from IGF-I expressing rSV40 vectors. A rSV40 vector encoding functional IGF-I (rSVIGF-I) was used to infect healthy male Wistar rats in which liver cirrhosis was induced by CCl4 inhalation during 36 weeks. At the end of this period rSVIGF-I-treated rats had normal levels of serum bilirubin and serum transaminases and showed a significant increase of IGFBP3, an IGF-I binding protein positively regulated by IGF-I. Interestingly, fibrosis score was reduced in rats that received CCl4 and rSVIGF-I as compared with control animals given CCl4. Moreover, testis weight was reduced in control cirrhotic rats but was normal in CCl4-treated rats that received rSVIGF-I. These results indicate that the rSVIGF-I vector is an efficient alternative for prevention and treatment of liver cirrhosis development.
RIVAROXABAN REDUCES SPONTANEOUS AND LARGE MYOCARDIAL INFARCTIONS: FINDINGS FROM THE ATLAS ACS 2 – TIMI 51 TRIAL
Authors: Matthew Cavender, Eugene Braunwald, C. Michael Gibson, Stephen Wiviott, Sabina Murphy, Marcos Amuchastegui, Anton Oude Ophuis, Maarten van Hessen, Jessica Mega
Journal: Journal of the American College of Cardiology (2013)
Aorta to Right Pulmonary Artery Anastomosis (Waterston's Operation) for Cyanotic Heart Disease
Authors: JANE SOMERVILLE, M. YACOUB, D. N. ROSS, K. ROSS
Journal: Circulation (1969)

Thirty patients with cyanotic heart disease, including Fallot's tetralogy, transposition of the great arteries, and tricuspid atresia had Waterston's anastomosis for gross effort intolerance or cyanotic attacks. The results were good in 28. Spontaneous closure of the anastomosis occurred in one patient. There was a tendency for preferential perfusion of the right lung, and unilateral pulmonary edema occurred in nine patients. Congestive heart failure appeared when the stoma was too large. Surgical technic to avoid kinking of the right pulmonary artery has been modified, and the importance of limiting the size of the anastomosis has been emphasized. Transaortic closure of the anastomosis through the aorta at the time of definitive correction was simple in three patients.
Mechanism of liposoluble drugs and general anaesthetic's membrane action: action of difluorodichloromethane (FC 12) on different types of cardiac fibres isolated from sheep hearts
Authors: Y. LESSARD, G. PAULET
Journal: Cardiovascular Research (1985)

Journal Article Mechanism of liposoluble drugs and general anaesthetic's membrane action: action of difluorodichloromethane (FC 12) on different types of cardiac fibres isolated from sheep hearts Get access YVON LESSARD, YVON LESSARD * From the Laboratoire de Physiologie Médicale, Universite de Rennes, Rennes, France * Address for correspondence and reprint requests: Dr Yvon Lessard, Laboratoire de Physiologie Mtdicale, Faculté de Médecine, 2 Avenue du Pr Léon Bernard, 35043 Rennes Cedex, France. Tel (16-99) 59.20. 20 poste 494. Search for other works by this author on: Oxford Academic PubMed Google Scholar GEORGES PAULET GEORGES PAULET From the Laboratoire de Physiologie Médicale, Universite de Rennes, Rennes, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 19, Issue 8, August 1985, Pages 465–473, https://doi.org/10.1093/cvr/19.8.465 Published: 01 August 1985
Predicting Outcome after Traumatic Brain Injury: Development and International Validation of Prognostic Scores Based on Admission Characteristics
Authors: Ewout W Steyerberg, Nino Mushkudiani, Pablo Perel, Isabella Butcher, Juan Lu, Gillian S McHugh, Gordon D Murray, Anthony Marmarou, Ian Roberts, J. Dik F Habbema, Andrew I. R Maas
Journal: PLoS Medicine (2008)

Background Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance. We aimed to develop prognostic models with readily available traditional and novel predictors. Methods and Findings Prospectively collected individual patient data were analyzed from 11 studies. We considered predictors available at admission in logistic regression models to predict mortality and unfavorable outcome according to the Glasgow Outcome Scale at 6 mo after injury. Prognostic models were developed in 8,509 patients with severe or moderate TBI, with cross-validation by omission of each of the 11 studies in turn. External validation was on 6,681 patients from the recent Medical Research Council Corticosteroid Randomisation after Significant Head Injury (MRC CRASH) trial. We found that the strongest predictors of outcome were age, motor score, pupillary reactivity, and CT characteristics, including the presence of traumatic subarachnoid hemorrhage. A prognostic model that combined age, motor score, and pupillary reactivity had an area under the receiver operating characteristic curve (AUC) between 0.66 and 0.84 at cross-validation. This performance could be improved (AUC increased by approximately 0.05) by considering CT characteristics, secondary insults (hypotension and hypoxia), and laboratory parameters (glucose and hemoglobin). External validation confirmed that the discriminative ability of the model was adequate (AUC 0.80). Outcomes were systematically worse than predicted, but less so in 1,588 patients who were from high-income countries in the CRASH trial. Conclusions Prognostic models using baseline characteristics provide adequate discrimination between patients with good and poor 6 mo outcomes after TBI, especially if CT and laboratory findings are considered in addition to traditional predictors. The model predictions may support clinical practice and research, including the design and analysis of randomized controlled trials.
The lymphoid lineage–specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells
Authors: Yinming Liang, Margot Cucchetti, Romain Roncagalli, Tadashi Yokosuka, Aurélie Malzac, Elodie Bertosio, Jean Imbert, Isaac J Nijman, Miloslav Suchanek, Takashi Saito, Christoph Wülfing, Bernard Malissen, Marie Malissen
Journal: Nature Immunology (2013)
Incidence of liver abnormalities in Fanconi anemia patients
Authors: Caroline Masserot‐Lureau, Nadir Adoui, Françoise Degos, Cédric de Bazelaire, Jean Soulier, Sylvie Chevret, Gérard Socié, Thierry Leblanc
Journal: American Journal of Hematology (2012)

Patients with Fanconi anemia (FA) are prone to liver tumors, especially after androgen treatment, but other liver abnormalities have not been described for these patients. Here, we systematically reviewed liver manifestations in a cohort of 64 adult and pediatric patients with FA followed in a single center. "Significant biological liver abnormalities(SBLA)" in the absence of any androgen treatment were found in five patients, including two children, belonging to rare FA groups; these two patients presented with a very severe chronic cytolysis pattern which may be classified as a new FA phenotype. Liver radiological abnormalities, which include hepatic tumors (n 5 4), hepatomegaly(n 5 1), hyperechogenicity (n 5 2), and a previously undescribed biliary duct dilatation as demonstrated by magnetic resonance cholangiopancreatography(MRCP) (n 5 2), were found in eight patients who received androgen treatment or who had iron overload. Lastly, we found no correlation between cytolysis intensity and high levels of alpha-fetoprotein (AFP); this common finding in FA patients cannot therefore be explained by hepatocyte regeneration.
Evidence-based testing of the hamstring muscles using wireless surface emg
Authors: K Kotila, T Sveinsson, Á Árnason
Journal: British Journal of Sports Medicine (2011)

Background The re-injury rate of the hamstring muscle group is reported as high as 12%. This emphasises the need for better testing procedures when considering increasing the workload or allowing a player to return to sport. Objective To test the between-days reliability of functional exercises of the hamstring muscles using wireless surface Electromyography (sEMG; Kine ehf). Design The study was a test-retest design and sEMG was recorded on the hamstring muscles bilaterally. The exercises are: Nordic Hamstring Lower (HL), One leg horizontal hop (HH), 30 m sprint (S). A normalisation procedure preceded the testing, using maximum voluntary contraction of the hamstring muscles as reference measurement. Participants and setting The physiotherapist/principal investigator and three physiotherapist students participated as testers. Male players from two local soccer teams and the sports college were invited to participate. Of 48 players that were invited, 22 accepted and 16 completed the testing. Only players with no physical ailments were allowed to participate. The testing took place at an indoor soccer facility. Methods For HL, maximum power output quantified as MaxRMS and the percentage of the drop in median frequency (MF) through repetitions was calculated. For HH, MaxRMS was calculated. For S, total power output and MF was calculated. Data was analyzed for each exercise using paired t-test. Typical error (TE) was calculated for test/retest. Results No systematic error was detected. HL (MaxRMS): TE ranging from 21% to 44%. HL (MF): TE ranging from 107% to 170%. More results are pending. Conclusion TE is ranging at an unacceptable high level for HL. MaxRMS shows a lower TE value for all muscles compared to MF, indicating that a true change in the muscles activity will be easier detected with MaxRMS. Future studies need to be done to determine the cause(s) for this lack of reliability and possible techniques that can improve it.
Aneurysm of the rabbit common carotid artery induced by periarterial application of calcium chloride in vivo.
Authors: S D Gertz, A Kurgan, D Eisenberg
Journal: Journal of Clinical Investigation (1988)

Experimental aneurysmatic dilatation of the rabbit common carotid artery was induced by a single, periarterial application of calcium chloride in vivo. Vessels were fixed in situ after 3 d, 1 wk, 3 wk, 6 wk, and 12 wk by intracardiac perfusion of glutaraldehyde and tissues prepared for light, scanning, and transmission electron microscopy. Progressive focal aneurysmal dilatation was seen limited to the site of calcium application with endothelial damage and thrombus formation in areas of irregular luminal contour. Disruption of the elastic network of the intima and media was seen with varying degrees of intimal fibromuscular hyperplasia and medial disorganization. The calcium-elastic tissue complex was the focus of the inflammatory, arteriosclerotic reaction and subsequent aneurysm formation. The inflammatory cell infiltration initially included primarily neutrophils followed by lymphocytes, plasma cells, monocytes, and multinucleated giant cells. These studies support the hypothesis that disruption of the elastic tissue network of the vascular wall represents an important pathogenetic factor in the initiation of aneurysmal dilatation. In addition, the results of these studies suggest that interaction of calcium with the elastica of the arterial wall may represent an important pathogenetic factor in the initiation of giant cell arteritis.
Points: Kidney pseudotumour diagnosed by emission computed tomography
Authors: E. M Watkin
Journal: BMJ (1983)

December, p 1617) of a patient in whom atenolol treatment apparently precipitated renal artery thrombosis.Recent reports suggest that the angiotensin converting enzyme inhibitor captopril may cause the same complication in patients with pre-existing renal artery stenosis.Oelkers' has described two patients with renovascular hypertension who developed renal artery occlusion during treatment with captopril, and, according to Hollenberg,' about 10% of patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney developed rapidly progressive renal failure during the first few weeks of treatment with captopril.Half of these patients recovered renal function with a reduction in dosage of captopril.No details of the remaining patients were given, but one might speculate that some or all of them may also have developed renal artery thrombosis.
Hypoglycemia in Patients With Diabetes on Antidiabetic Medications Who Fast for Laboratory Tests
Authors: Saleh Aldasouqi, Ahmad Sheikh, Pam Klosterman, Sheila Kniestedt, Lisa Schubert, Rosie Danker, Mary Austin
Journal: Diabetes Care (2011)

We would like to report the results of a pilot study that we undertook to evaluate the risk of hypoglycemia in patients with diabetes on antidiabetic medications because of the repeated calls from our laboratory reporting critical glucose results, typically after patients who had come earlier for blood tests had already left the laboratory. We have become increasingly concerned about these occurrences and realized that our patients may not be adequately educated on the proper preparation for tests requiring overnight fasting.

Patients with diabetes are generally given instructions regarding medication adjustments when they fast overnight for surgical or diagnostic procedures, but we became concerned that there may not be such instructions for overnight fasting for laboratory tests. It could be argued that some clinicians may take the initiative of providing such instructions. However, being diabetes specialists ourselves, we acknowledge that we had not paid adequate attention to this issue. Similarly, from talking with diabetes educators (S.A., personal communications), we realized that this educational piece is not included in traditional curricula. Extensive literature search retrieved no publications on this critical issue or educational guidelines on how to prepare patients with …
Characterization of a Human Monoclonal Antibody With Broad Reactivity to Malignant Tumor Cells1
Authors: H. Saito, K. Uchiyama, I. Nakamura, H. Hiraoka, Y. Yamaguchi, M. Taniguchi
Journal: JNCI Journal of the National Cancer Institute (1988)

Lymphocytes from mediastinal lymph nodes of 9 patients with primary lung cancer were fused with murine myeloma cells (P3U1). One of the clones (4G12) was stable for secretion (10 μg/ml) of human IgMλ for 24 months. The antigen detected by 4G12 was sensitive to both trypsin and periodic acid-Schiff treatment. It immunoprecipitated a glycoprotein with an Mr of 65,000 upon analysis in sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reduced conditions. Immunohistochemical staining demonstrated that 4G12 possessed a high reactivity to squamous cell carcinomas of the lung (29 of 29) and also reacted with other lung carcinomas [adenocarcinomas (14 of 20) and large cell carcinomas (3 of 8)] and with some nonpulmonary malignant tumors (15 of 56). However, it did not react with small cell carcinomas of the lung. No benign tumors (0 of 26) so far tested have been positive. 4G12 did not react with most of the normal tissues; an exception was that it was weakly reactive on the glandular cells of the trachea and bronchi and on the proximal tubular cells of the kidneys. Thus 4G12 showed a broad reactivity to malignant tumors (68% of lung carcinomas, 27% of nonpulmonary carcinomas, and 0% of benign tumors). The reactivity of 4G12 on tissues from squamous cell carcinomas of the lung indicated that the expression of the antigenic determinant was much more in the well-differentiated grade than in the poorly differentiated grade. Thus the antigen detected by 4G12 appears to be related to tumor differentiation. Moreover, fluorescence-activated cell sorter analysis demonstrated that the expression of the antigen epitope depended on the cell cycle (G2-M). These data suggest that the 4G12 monoclonal antibody detects a new tumor-associated antigen that is recognized by the human immune system. [J Natl Cancer Inst 1988;80:728–734]
Serial Hemodynamics During Intra-aortic Balloon Counterpulsation for Cardiogenic Shock
Authors: RALPH B. DILLEY, JOHN ROSS, EUGENE F. BERNSTEIN
Journal: Circulation (1973)

The use of intra-aortic balloon counterpulsation (IABC) has achieved some success in the treatment of cardiogenic shock, but there has been little objective documentation of the serial hemodynamic effects of counterpulsation in man. Six patients who satisfied strict criteria for refractory cardiogenic shock were treated with IABC. The following determinations were made serially: systemic blood pressure (BP), pulmonary artery pressures (PAP), pulmonary artery wedge pressure (PAW), cardiac index (CI), stroke volume index (SVI), and A-VO 2 difference. The average duration of balloon assist was 5.8 days (range 1.5 to 21 days). There was immediate improvement in all patients in that pressors could be maintained at lower levels. Although mean systolic BP did not change significantly from control values, augmented diastolic BP was maintained between 112 and 120 mm Hg. Initially, there were significant decreases in mean PAP (–13.4 mm Hg, P &lt; 0.02), mean PAW (–10 mm Hg, P &lt; 0.01), and A-VO 2 difference (–2.12 ml/100 ml) and increases in CI (+ 1.02 L/min/m 2 , P &lt; 0.05). The improvement in diastolic BP, CI, and A-VO 2 difference persisted in each patient, but mean PAP increased from 22.6 to 32.3 mm Hg ( P &lt; 0.05) and mean PAW from 14.4 to 22 mm Hg ( P &lt; 0.05) by the fourth day of IABC. We conclude that IABC causes marked immediate improvement in hemodynamic variables and that prolonged survival is possible. However, progressive elevation of mean PAP and PAW, reflecting deterioration of left ventricular function, occurs and can prohibit a successful outcome with IABC alone.
Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report
Authors: Leslie K. Jacobsen, Julie K. Staley, Sami S. Zoghbi, John P. Seibyl, Thomas R. Kosten, Robert B. Innis, Joel Gelernter
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: Evidence of a relationship between genotype and binding availability was assessed for the dopamine and serotonin transporter genes. METHOD: The authors assessed dopamine transporter genotype at the SLC6A3 3′ variable number of tandem repeats (VNTR) polymorphism and serotonin transporter genotype at the SLC6A4 promotor VNTR polymorphism in 30 healthy subjects who also underwent single photon emission computed tomography with [123I]β-CIT. RESULTS: Subjects homozygous for the 10-repeat allele at the SLC6A3 locus demonstrated significantly lower dopamine transporter binding than carriers of the nine-repeat allele. There was no effect of SLC6A4 genotype upon serotonin transporter binding. CONCLUSIONS: These findings suggest that genetic variation at the SLC6A3 3′ VNTR polymorphism may modify dopamine transporter function.
Impact of Nationwide Catastrophic Health Insurance
Authors: George H. Harris, Harry B. Wissmann
Journal: New England Journal of Medicine (1975)

Of the national health-insurance proposals currently before the Congress, most include some coverage for catastrophically expensive illness and several provide catastrophic coverage only. A study recently completed by Arthur D. Little, Incorporated for the Health Resources Administration, United States Department of Health, Education, and Welfare (DHEW), examined the impact on health-care costs and service utilization of a nationwide catastrophic health-insurance program covering persons under the age of 65. The study found that such a program could be expected to have very minor inflationary effects, even without an upper limit on benefits. Benefits under Senator Russell B. Long's Catastrophic Health Insurance . . .
ACUTE AND CHRONIC BACILLARY DYSENTERY AND CHRONIC ULCERATIVE COLITIS
Authors: Joseph Felsen
Journal: JAMA (1953)

During the past two decades there has occurred an increasing interest in the subject of the infectious diarrheas, particularly bacillary dysentery and chronic ulcerative colitis. It is our purpose to present the newer and poorly understood features of acute bacillary dysentery and to establish a relationship between it and chronic ulcerative colitis.  RISING INCIDENCE OF ACUTE BACILLARY DYSENTERY  In 1933, we directed attention to the inadequacy of available data on the prevalence of acute bacillary dysentery in the United States. 1 In 15 states it was not even a reportable disease. This condition was subsequently corrected through the cooperation of public health officials. We also pointed out new and atypical clinical forms of the disease and described a characteristic three stage progression of intestinal pathological change readily demonstrable at sigmoidoscopy. Due largely to the work of Boyd, 2 a more accurate classification of dysentery strains by serologic methods became available.