Subcutaneous Compared with Intravenous Heparin for Deep Vein Thrombosis
Authors: Kenneth M. Moser, Peter F. Fedullo
Journal: Annals of Internal Medicine (1992)

Letters1 August 1992Subcutaneous Compared with Intravenous Heparin for Deep Vein ThrombosisKenneth M. Moser, MD, Peter F. Fedullo, MDKenneth M. Moser, MDSearch for more papers by this author, Peter F. Fedullo, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-3-265 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The meta-analysis reported by Hommes and colleagues (1) is likely to rekindle a long-simmering controversy about the relative safety and efficacy of subcutaneous compared with continuous intravenous heparin for the treatment of acute venous thromboembolism. Our reading of the extensive literature in this field has led us to conclude that these two (and other) methods of heparin administration appear to be equally safe and effective. Their meta-analysis, however, neglected the role of the activated partial thromboplastin time (APTT) response in monitoring.Their inference that using subcutaneous heparin may allow us to "achieve early ambulation . . ....Reference1. HommesBuraMazzolaiBüllerten Cate DALHJ. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. Ann Intern Med. 1992;116:279-84. LinkGoogle Scholar1. HommesBuraMazzolaiBüllerten Cate DALHJ. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. Ann Intern Med. 1992;116:279-84. LinkGoogle Scholar2. YoungEhrenpreisEhrenpreisKirshblum MEMS. Heparin-associated thrombocytopenia and thrombosis syndrome in a rehabilitation patient. Arch Phys Med Rehabil. 1989;70:468-70. CrossrefMedlineGoogle Scholar3. HyersHullWeg TRJ. Antithrombotic therapy for venous thromboembolic disease. Arch Intern Med. 1986; 146:147. Google Scholar4. HyersHullWeg TRJ. Antithrombotic therapy for venous thromboembolic disease. Chest. 1989;95:515. CrossrefGoogle Scholar1. HommesBuraMazzolaiBüllerten Cate DALHJ. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. Ann Intern Med. 1992;116:279-84. LinkGoogle Scholar1. HommesBuraMazzolaiBüllerten Cate DALHJ. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. Ann Intern Med. 1992;116:279-84. LinkGoogle Scholar2. PrandoniLensingBüllerCartaCogoVigo PAHMAM. Comparison of subcutaneous low-molecular-weight heparin with intravenous standard heparin in proximal deep-vein thrombosis. Lancet. 1992;339:441-5. CrossrefMedlineGoogle Scholar3. HullRaskobPineoGreenTrowbridgeElliott RGGDAG. Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis. N Engl J Med. 1992;326:975-82. CrossrefMedlineGoogle Scholar1. HommesBuraMazzolaiBüllerten Cate DALHJ. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. Ann Intern Med. 1992;116:279-84. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA randomized trial of the effect of low molecular weight heparin vs. warfarin on mortality in the long-term treatment of proximal vein thrombosisManagement of Suspected Acute Venous Thromboembolism in a General and Maternity HospitalLow molecular weight heparin treatment of venous thromboembolismLow-molecular-weight Heparins for the Treatment of Venous Thromboembolism 1 August 1992Volume 117, Issue 3Page: 265-266KeywordsDeep vein thrombosisHeparinPartial thromboplastin timeSafetyVenous thromboembolismWalking Issue Published: 1 August 1992 PDF DownloadLoading ...