Pancytopenia with Cimetidine
Authors: C. DE GALOCSY
Journal: Annals of Internal Medicine (1979)

Letters1 February 1979Pancytopenia with CimetidineC. DE GALOCSY, M.D., C. VAN YPERSELE DE STRIHOU, M.D.C. DE GALOCSY, M.D.Search for more papers by this author, C. VAN YPERSELE DE STRIHOU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-274_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Cimetidine has been recently implicated in the development of five cases of agranulocytosis and in one case of pancytopenia (1-6). We have seen an additional case in which the development of severe pancytopenia was apparently related to cimetidine treatment.A 45-year-old diabetic man had been dialysed since 1973 for terminal renal failure due to diabetic glomerulosclerosis. A duodenal ulcer had been diagnosed in 1970, with relapses in 1972 and 1973. In 1974 an abortive attempt to transplant a cadaver kidney was complicated by gastrointestinal hemorrhage, without documented recurrence of the ulcer.Cimetidine, 400 mg/day was started on...References1. CRAVENWHITTINGTON EJ: Agranulocytosis four months after cimetidine therapy (letter). Lancet 2:294-295, 1977 CrossrefMedlineGoogle Scholar2. JOHNSONBLACKHUGHESCLARKE NAAS: Leucopenia with cimetidine (letter). Lancet 2:1226, 1977 CrossrefGoogle Scholar3. UFBERGBROOKSBOSANACKINTZEL MCPJ: Transient neutropenia in a patient receiving cimetidine. Gastroenterology 73:635-638, 1977 CrossrefMedlineGoogle Scholar4. LÓPEZ-LUQUERODRIGUEZ-CUARTEROPÉREZ-GÁLVEZPOMARES-MORAPEÑA-YÁÑEZ AANJA: Cimetidine and bone-marrow toxicity (letter). Lancet 1:444, 1978 CrossrefMedlineGoogle Scholar5. KLOTZKAY SB: Cimetidine and agranulocytosis (letter). Ann Intern Med 88:579-580, 1978 LinkGoogle Scholar6. JAMESPROUT CB: Marrow suppression and intravenous cimetidine (letter). Lancet 1:987, 1978 CrossrefMedlineGoogle Scholar7. BYRON J: Cimetidine and bone-marrow toxicity (letter). Lancet 2:555-556, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cliniques Universitaires St-Luc 1200 Brussels Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcersHistamine and the BloodCimetidine induced pancytopeniaRanitidine Fails to Suppress the Growth in vitro of Haemopoietic Progenitors from Human Peripheral Blood or Bone MarrowHaematological Adverse Effects of Histamine H2-Receptor AntagonistsRational approach to long-term use of H2-antagonistsCimetidine in DermatologyAdverse Reactions and Interactions with H2-Receptor AntagonistsAcute Stress UlcerationCimetidine suppression of CFU-C in malesRanitidineRanitidine: A New H 2 -Receptor AntagonistCimetidine and GranulopoiesisS. ERIDANI, M.D., I.D.A. JOHNSTON, M.R.C.P., S. VILLA, B.SC.EFFECTS OF CIMETIDINE ON HAEMATOPOIESIS in vitroFATAL AGRANULOCYTOSIS ATTRIBUTABLE TO CIMETIDINECimetidine and hematologic suppressionCimetidine-lnduced GranulocytopeniaHARRY W. CARLOSS, M.D., MEHDI TAVASSOLI, M.D., ROBERT MCMILLAN, M.D.AntihistaminesBone-Marrow Suppression Associated with CimetidineHENRY K. CHANG, M.D., STEPHEN L. MORRISON, M.D.Cimetidine and Impaired Renal FunctionGORDON D. LUK, M.D., WENDY J. LUK, M.S., THOMAS R. HENDRIX, M.D.Cimetidine and AgranulocytosisFIRAS H. AL-KAWAS, M.D., BRUCE A. LENES, M.D., RONALD A. SACHER, M.D.Cimetidine, Cloxacillin, and PancytopeniaERIC L. WESTERMAN, M.D.Drug Evaluation After MarketingDENNIS SLONE, M.D., SAMUEL SHAPIRO, M.B., OLLI S. MIETTINEN, M.D.Ph.D., WILLIAM D. FINKLE, Ph.D., PAUL D. STOLLEY, M.D.Cimetidine and GranulocytopeniaJAMES W. FRESTON, M.D. 1 February 1979Volume 90, Issue 2Page: 274-274KeywordsDuodenal ulcersGastrointestinal hemorrhageRenal failureRenal transplantationUlcers Issue Published: 1 February 1979 PDF downloadLoading ...