tbuckley/cabot-search huggingface dataset:
Abstract 2306: MicroRNA 199a*: a potent suppressor of tumor metastasis and angiogenesis.
Authors: Alip Ghosh, Amit Ghosh, Debanjali Dasgupta, Shrabasti Roychowdhury, Shrabasti Roychowdhury, Simanti Datta, Abhijit Chowdhury, Soma Banerjee
Journal: Cancer Research (2013)

Abstract The growth of a solid tumor depends on diffusion of nutrients from the tumor microenvironment through vascular system. Angiogenesis, the new blood vessels formation is the primary route by which tumor cells get nutrients as well as exit from primary site and enter into the blood circulation. The proliferation and migration of vascular endothelial cells are triggered by angiogenic growth factors secreted by tumor cells, such as VEGF, TGF-β etc. Recent evidences showed HGF also plays an important role in angiogenesis by enhancing the proliferative activity and intracellular signaling. HGF/its receptor, c-MET and VEGF/VEGFR1 are two independent pathways for angiogenesis and metastasis. Thus detection of a molecule that hits both pathways could be a potent therapeutic agent that could facilitate the inhibition of improved barrier function. Recently mir199a* has been shown to target both CD44 and cMET molecule to block the metastasis in cancer. The present study aim to show that mir199a* also target HGF, the key modulator of the HGF/c-Met signaling cascade in epithelial cells to shut off the mesenchymal transition and VEGFR1 to prevent angiogenesis more effectively. Luciferase 3’ UTR assay was performed to investigate HGF as a target of mir-199a*. HGF mRNA and protein expression was determined by real time RT-PCR, Western blot analysis in liver stellate cell line LX2 transfected with mir-199a* and HGF shRNA. The cultured media of mir-199a* transfected LX2 cells was used to verify the effect of mir-199a* on HGF induced migration and invasion ability on metastatic cell lines using Boyden chamber assay with or without matrigel coated membrane and angiogenesis by tube formation assay. The mir-199a* binding site was detected by pictar, target scan analysis of the 3’UTR of HGF and VEGFRs. The binding of mir-199a* to the 3′UTR of HGF and VEGFR1 were confirmed by luciferase assay, mutagenesis and western blotting. Down regulation of HGF protein expression in HGF producing hepatic stellate cell, LX2 was observed by mir-199a*. Addition of LX2 conditioned media transfected with mir199a* to metastatic cell reduces the migration and invasion and also block angiogenesis in endothelial cells. As Mir-199a* could target HGF/cMET, CD44-cMET and VEGF/VEGFR1 signaling cascade, it could be used as a potential therapeutic target of HCC. Citation Format: Alip Ghosh, Amit Ghosh, Debanjali Dasgupta, Shrabasti Roychowdhury, Shrabasti Roychowdhury, Simanti Datta, Abhijit Chowdhury, Soma Banerjee. MicroRNA 199a*: a potent suppressor of tumor metastasis and angiogenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2306. doi:10.1158/1538-7445.AM2013-2306
Radiation Therapy for Age-Related Macular Degeneration
Authors: Paul T. Finger
Journal: JAMA (1997)

To the Editor.  —While I commend Mr Skolnick 1 for covering this promising experimental treatment option for  (neovascular) macular degeneration, it was disturbing that only radiation oncologists were quoted with respect to the results of treatment. Since ophthalmologists were (or should have been) required to evaluate each patient's eligibility, measure visual acuity, and determine funduscopic changes, why were they conspicuously absent in the article?  As an ophthalmologist and specialist in ophthalmic radiation therapy, I have determined eligibility, supervised irradiation, and provided follow-up care for 300 patients with wet macular degeneration. I have determined that each patient had the wet form of macular degeneration, determined that each patient should be referred for radiation therapy consultation, treatment, or both, and followed up with each closely for evidence of both adverse effects and response to treatment. During the last 4 years, we have reviewed our charts periodically and noted few adverse effects
Increased Risks of Coronary Heart Disease and Stroke Among Spousal Caregivers of Cancer Patients
Authors: Jianguang Ji, Bengt Zöller, Kristina Sundquist, Jan Sundquist
Journal: Circulation (2012)

Background— Spousal caregivers of cancer patients suffer psychological and physical burdens that may affect their risk of subsequently developing coronary heart disease and stroke. Methods and Results— Cancer patients were identified in the Swedish Cancer Registry, and information on their spouses was retrieved from the Swedish Multi-Generation Register. Follow-up of caregivers was performed from the date of the first diagnosis of cancer in their spouses through 2008. Standardized incidence ratios were calculated for spousal caregivers of cancer patients compared with those without an affected spouse. After the cancer diagnosis in wives, the risks of coronary heart disease, ischemic stroke, and hemorrhagic stroke in husbands were 1.13 (95% confidence interval [CI], 1.10–1.16), 1.24 (95% CI, 1.21–1.27), and 1.25 (95% CI, 1.18–1.32), respectively. The corresponding risks in wives with an affected husband were 1.13 (95% CI, 1.10–1.16), 1.29 (95% CI, 1.26–1.32), and 1.27 (95% CI, 1.19–1.34). The increases were consistent over time and were more pronounced if the spouse was affected by a cancer with a high mortality rate, such as pancreatic and lung cancers. Conclusions— Spousal caregivers of cancer patients have increased risks of coronary heart disease and stroke that persist over time. Clinical attention should be paid to spousal caregivers, especially those caring for cancer patients with high mortality rates.
Exposure to Perfluoroalkyl Acids and Markers of Kidney Function among Children and Adolescents Living near a Chemical Plant
Authors: Deborah J. Watkins, Jyoti Josson, Beth Elston, Scott M. Bartell, Hyeong-Moo Shin, Veronica M. Vieira, David A. Savitz, Tony Fletcher, Gregory A. Wellenius
Journal: Environmental Health Perspectives (2013)

Serum levels of perfluorooctanoic acid (PFOA) have been associated with decreased renal function in cross-sectional analyses, but the direction of the association is unclear. We examined the association of measured and model-predicted serum PFOA concentrations with estimated glomerular filtration rate (eGFR), a marker of kidney function, in a highly exposed population (median serum PFOA, 28.3 ng/mL). We measured serum creatinine, PFOA, perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) and calculated eGFR in 9,660 children 1 to < 18 years of age at study enrollment. We predicted concurrent and historical serum PFOA concentrations using a validated environmental, exposure, and pharmacokinetic model based on individual residential histories, and used linear regression to estimate the association between eGFR and measured and predicted serum PFOA concentrations. We hypothesized that predicted serum PFOA levels would be less susceptible to reverse causation than measured levels. An interquartile range increase in measured serum PFOA concentrations [IQR ln(PFOA) = 1.63] was associated with a decrease in eGFR of 0.75 mL/min/1.73 m(2) (95% CI: -1.41, -0.10; p = 0.02). Measured serum levels of PFOS, PFNA, and PFHxS were also cross-sectionally associated with decreased eGFR. In contrast, predicted serum PFOA concentrations at the time of enrollment were not associated with eGFR (-0.10; 95% CI: -0.80, 0.60; p = 0.78). Additionally, predicted serum PFOA levels at birth and during the first ten years of life were not related to eGFR. Our findings suggest that the cross-sectional association between eGFR and serum PFOA observed in this and prior studies may be a consequence of, rather than a cause of, decreased kidney function.
Genome-wide expression profiling of B lymphocytes reveals IL4R increase in allergic asthma
Authors: Marien Pascual, Sergio Roa, Asunción García-Sánchez, Catalina Sanz, Laura Hernandez-Hernandez, John M. Greally, Félix Lorente, Ignacio Dávila, María Isidoro-García
Journal: Journal of Allergy and Clinical Immunology (2014)
Genome-wide association study of the age of onset of childhood asthma
Authors: Erick Forno, Jessica Lasky-Su, Blanca Himes, Judie Howrylak, Clare Ramsey, John Brehm, Barbara Klanderman, John Ziniti, Erik Melén, Goran Pershagen, Magnus Wickman, Fernando Martinez, Dave Mauger, Christine Sorkness, Kelan Tantisira, Benjamin A. Raby, Scott T. Weiss, Juan C. Celedón
Journal: Journal of Allergy and Clinical Immunology (2012)
Abdominal Pain in a Runner
Authors: Kenneth Stevens
Journal: JAMA (1983)

<h3>To the Editor.—</h3> In the reply to a question regarding the workup of abdominal pain in an otherwise healthy 17-year-old female distance runner (1983;249:409), I believe that several important points were omitted. Many distance runners will readily admit that running by itself is a natural cathartic. Severe stresses such as competition or intense practices can easily cause gastrointestinal (GI) distress. As previously noted (1980;243:1743), the increased parasympathetic nervous system tone found in runners could be involved with increasing baseline GI tract peristaltic activity in this patient. In addition, relative gut ischemia during exertion (1981;246:1404) could also be involved. Several key questions in the data base must be answered. Have there been any substantial changes in diet? Was there any history of lactose intolerance, malabsorption, or excessive carbohydrate intake (any of which could cause an osmotic diarrhea)? Was the stool checked for ova and parasites? Was the development of the patient's
Bioethics and the Future of Medicine: A Christian Appraisal
Authors: David C. Thomasma
Journal: JAMA (1996)

There is an increasing backlash to secular bioethics today, and it will continue to grow. Evidence of this backlash is found in the creation of a new journal devoted to theologically recovering the sources of bioethics, and in religious institutes focusing on the losses of traditional Hippocratic conceptions of medicine and medicine's duties to patients caused by an ever-growing entrepreneurial spirit of medicine during the past 50 years. The editors and authors in this timely collection share a conviction that the postmodern and post-Christian era reconstructs human nature to fit its own ends—ends that are manipulative rather than healing. Persons and nature itself are made exceptionally vulnerable as a result. Predictably, changes in practice inevitably create changes in understanding. Alterations in traditional medicine and the myriad cultural and philosophical responses to those alterations have raised recent concerns that traditional Judeo-Christian values and the Hippocratic commitment to the primacy of the
Access to primary care
Authors: P. Hall, I. van der Loeff, R. Feldman, R. Bragg, F. Qureshi, M. Birch, Y. Azad, L. Power, S. Sceats
Journal: BMJ (2009)

Newdick’s editorial on failed asylum seekers’ legal entitlements to free NHS health care requires comment.1

Firstly, nobody is excluded by law from free NHS primary health care because of their residency or immigration status. General practitioners retain a discretion to register failed asylum seekers to the same extent that …
An introduction to philosophical medical ethics: the Arthur case.
Authors: R Gillon
Journal: BMJ (1985)

The application of moral theory to decisions involving medical ethics is illustrated by the 1981 case in which a British pediatrician, Dr. Leonard Arthur, was acquitted of attempted murder for prescribing dihydrocodeine and "nursing care only" for a Down's syndrome newborn after the child had been rejected by his mother. Gillon outlines the moral arguments of the "prosecution" and the "defense," and then categorizes their various premises in accordance with concepts of normative ethical theory.
Plasma 25-Hydroxyvitamin D Concentration and Metabolic Syndrome Among Middle-Aged and Elderly Chinese Individuals
Authors: Ling Lu, Zhijie Yu, Xu Lin
Journal: Diabetes Care (2009)

We thank Hjelmesaeth et al. (1) for their comments on our recent publication (2). It would be ideal to evaluate the effects of plasma parathyroid hormone (PTH), calcium, and 25-hydroxyvitamin D [25(OH)D] simultaneously on metabolic syndrome; however, with limited plasma samples, neither PTH nor calcium could be measured in our study. Nonetheless, besides reporting that PTH level was associated with metabolic …
When Walking Fails: Mobility Problems of Adults with Chronic Conditions
Authors: Helen Hoenig
Journal: Annals of Internal Medicine (2003)

Medical Writings: Book Notes5 August 2003When Walking Fails: Mobility Problems of Adults with Chronic ConditionsHelen Hoenig, MD, MPHHelen Hoenig, MD, MPHDuke University Medical Center and Physical Medicine and Rehabilitation Service, Durham Veterans Affairs Medical Center, Durham, North Carolina.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-3-200308050-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Iezzoni L. 355 pages. Berkeley: Univ of California Pr. $19.95. ISBN 0520238192. Order at www.ucpress.edu.Field of medicine: Internal medicine, rheumatology, geriatrics, neurology, family practice, physical medicine, and rehabilitation.Format: Softcover book.Audience: Primary care practitioners, physician specialists treating patients with mobility disorders, residents, medical students, nurses, rehabilitation therapists, and consumers.Purpose: This book focuses on the issues that arise as progressive chronic health conditions compromise patients' everyday lives, with two goals: 1) advocating for community-dwelling Americans who have difficulty walking and 2) informing policymakers about health insurance and other public policies that are barriers to improving mobility.Content: The ... Author, Article, and Disclosure InformationAffiliations: Duke University Medical Center and Physical Medicine and Rehabilitation Service, Durham Veterans Affairs Medical Center, Durham, North Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 August 2003Volume 139, Issue 3Page: 236KeywordsDisabilitiesEpidemiologyHealth insurancePhysical functioningPublic policyRehabilitation medicineRheumatologySoftware toolsSystemic diseasesWalking ePublished: 5 August 2003 Issue Published: 5 August 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Letter: Phenformin and lactic acidosis.
Authors: J C Edwards
Journal: BMJ (1976)

when the patient was ill and taking drugs.These drugs may have included (for example) aspirin, which can be a potent cause of hyperuricaemia.Such a diagnosis would be acceptable only if urate crystals had been identified in the joint aspirate, a simple test which for some reason was neglected here.The information provided suggests that the patient actually had a pyo- genic arthritis partly suppressed by antibiotics.The second error was in management.Treating acute gout with a short course of allopurinol is not only useless but may actually be harmful by provoking a new attack.
S118 The ventilatory response to CO2 within obstructive sleep apnea patients
Authors: CMN Earing, JP Moore, DJ McKeon, H-P Kubis
Journal: Thorax (2013)

<h3>Introduction</h3> Obstructive Sleep Apnea (OSA) is a condition defined by the collapse of the upper airway and cessation of respiration during sleep. The resulting hypoventilation leads to intermittent nocturnal hypoxia and increased arterial pCO<sub>2 </sub>(hypercapnia). Control of ventilation is largely dependent on two interactive pathways, the central and peripheral chemoreceptors. Both chemoreceptors’ respond to H<sup>+</sup> ions liberated as a result of the presence of CO<sub>2.</sub> However, the peripheral chemoreceptors also respond to hypoxia particularly when PaO<sub>2</sub> falls below 70 Torr. Hypoxia has a synergistic effect on the ventilatory response to CO<sub>2</sub>. Our study therefore investigated the ventilatory response to CO<sub>2</sub> with and without the presence of moderate hypoxia to determine whether the central and/or peripheral chemoreflex response to CO<sub>2</sub> is modified with the development of OSA. <h3>Methods</h3> The ventilatory response to CO<sub>2 </sub>amongst 33 newly diagnosed male OSA patients (AHI: 32.6 ± 24.8; age: 53.1 ± 10.3 years, BMI: 36.4 ± 6.8 kg/m<sup>2</sup>) was measured whilst breathing four different gas mixtures balanced with N<sub>2</sub> (Mixture 1: ambient air; mixture 2: 25% O<sub>2</sub>/6% CO<sub>2</sub>; mixture 3: 13% O<sub>2</sub>; mixture 4: 13% O<sub>2</sub>/6% CO<sub>2</sub>). The minute ventilation of each participant, normalised by their body surface area (BSA), was recorded with subjects blinded to the order of test gases. Additionally, fasted venous blood samples were taken to assess plasma leptin concentrations. <h3>Results</h3> Mild and moderate OSA patients (AHI: 13.76 ± 7.01) revealed a significantly (<i>p</i> &lt;.01) greater change in their ventilatory response to the hyperoxic-hypercapnic gas mixture (5.22 ± 1.95 l x min<sup>-1 </sup>x BSA<sup>-1</sup>) compared to severe OSA patients (AHI: 55.31 ± 18.25) (3.26 ± 1.64 l x min<sup>-1 </sup>x BSA<sup>-1</sup>). There was no significant change in ventilation between the hyperoxic and hypoxic-hypercapnic conditions in both groups. A significant negative correlation (r = -0.39; <i>p</i> &lt;.05) was found between AHI and ventilation change (l x min<sup>-1 </sup>x BSA<sup>-1</sup>) to the hyperoxic-hypercapnic gas mixture. <h3>Conclusion</h3> These findings suggest the reduced ventilatory response to hypercapnia amongst severe OSA patients is likely a result of adaptation to the central chemoreceptors.
Pen Marking Technique for Safer Polypectomy with Detachable Snares
Authors: Y. Tomiki, K. Shinmura, T. Maeda, Y. Kojima, K. Terai, S. Kasamaki, Y. Ishibiki, K. Sakamoto, T. Nakajima, T. Kamano
Journal: Endoscopy (2005)

The detachable snare designed by Hachisu [1] is a useful and safe instrument for preventing hemorrhage during and after endoscopic polypectomy for large pedunculated polyps in the colon.
Effects of Hyperoxia on Ventilatory Limitation During Exercise in Advanced Chronic Obstructive Pulmonary Disease
Authors: DENIS E. O'DONNELL, CHRISTINE D'ARSIGNY, KATHERINE A. WEBB
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

We studied interrelationships between exercise endurance, ventilatory demand, operational lung volumes, and dyspnea during acute hyperoxia in ventilatory-limited patients with advanced chronic obstructive pulmonary disease (COPD). Eleven patients with COPD (FEV1.0 = 31 ± 3% predicted, mean ± SEM) and chronic respiratory failure (PaO2 52 ± 2 mm Hg, PaCO2 48 ± 2 mm Hg) breathed room air (RA) or 60% O2 during two cycle exercise tests at 50% of their maximal exercise capacity, in randomized order. Endurance time (Tlim), dyspnea intensity (Borg Scale), ventilation (V˙ e), breathing pattern, dynamic inspiratory capacity (ICdyn), and gas exchange were compared. PaO2 at end-exercise was 46 ± 3 and 245 ± 10 mm Hg during RA and O2, respectively. During O2, Tlim increased 4.7 ± 1.4 min (p < 0.001); slopes of Borg, V˙ e, V˙ co 2, and lactate over time fell (p < 0.05); slopes of Borg–V˙ e, V˙ e–V˙ co 2, V˙ e–lactate were unchanged. At a standardized time near end-exercise, O2 reduced dyspnea 2.0 ± 0.5 Borg units, V˙ co 2 0.06 ± 0.03 L/min, V˙ e 2.8 ± 1.0 L/min, and breathing frequency 4.4 ± 1.1 breaths/min (p < 0.05 each). ICdyn and inspiratory reserve volume (IRV) increased throughout exercise with O2 (p < 0.05). Increased ICdyn was explained by the combination of increased resting IRV and decreased exercise breathing frequency (r2 = 0.83, p < 0.0005). In conclusion, improved exercise endurance during hyperoxia was explained, in part, by a combination of reduced ventilatory demand, improved operational lung volumes, and dyspnea alleviation.
Isolated Fracture of the Carpal Cuneiform
Authors: W. P. Greening
Journal: BMJ (1942)

LUNG TUMOURS IN MICE MEDIBRLOURNArlonger was threefold that for controls.Certain of the increases were ndt so impressive as expected.Some of these dusts (Czechoslovak, tarred road, silica, iron oxide) are under sus- picion as causes of lung tumours in man.Heredity, age, the so-called carcinogenic agents, and some dusts are definite factors in the experimental development of lung tumours in mice.Efforts to inhibit lung tumours with alumina or calcium carbonate were unsuccessful.The dusts produced about a fourfold increase in the incidence of hyperplasia of lymph tissue in the lungs and a threefold increase for tracheo-bronchial lymph glands.There was also an increase in most experiments in the incidence of the pneumonias.Silicotic nodules were produced in the tracheo-bronchial Iymph glands of mice breathing an amorphous silica; this confirms the first (Campbell, 1940(Campbell, , 1941) ) demonstration of silicosis produced without the crystal unit of quartz.I am indebted to Prof. J. Lowy for the active sample of Czechoslovak dust; to my colleague Dr. H. King's department for some a4yice and help with certain of the analyses to Mr. C.
Reversal of sterilisation.
Authors: A Cartwright
Journal: BMJ (1977)

It is difficult to know what conclusions one can reach in a study of 103 women who asked for reversal of sterilization (Mr. R.M.L. Winston, July 30, p. 305) when there are no data about the numbers and characteristics of the women who were sterilized and have not asked for reversal. And Mr. Winston's conclusion that it "seems unwise to sterilise women under 30 particularly immediately after pregnancy or if their marriage is in jeopardy" is therefore difficult to justify and has a disconcertingly paternalistic ring. It also implies that the stability or otherwise of a marriage should be a prime concern of obstetricians when women request sterilization. But what distrubed me most about Mr. Winston's article was his statement that "most women in this survey had been told that termination would not be undertaken without sterilisation." I wonder if this form of ultimatum, which Mr. Winston condemns, is likely to increase now that this operation is performed under a fee-for-service system?
Points: Olympics for the handicapped
Authors: J R Mirrey
Journal: BMJ (1979)

Iliopsoas abscess is a very rare pathology in the neonatal period. There is a lack of reports in the literature on bilateral psoas abscess with hip joint arthritis. We report a case of bilateral iliopsoas abscess with concomitant right hip septic arthritis, caused by methicillin-resistant Staphylococcus aureus in a 28-day-old male infant. The baby presented with bilateral diffuse swelling of the groins and upper thighs. He was treated successfully by ultrasound-guided percutaneous drainage along with systemic antibiotic therapy. Clinical improvement was observed within 24-48 hours of drainage.
Clinical results and in vivo valve function after implantation of a bicer valve prosthesis in the aortic position
Authors: Kanji Kawachi, Soichiro Kitamura, Ryuichi Morita, Tsutomu Nishii, Toshio Seki, Shigeki Taniguchi, Kiyoshi Inoue
Journal: Journal of the American College of Cardiology (1989)