tbuckley/cabot-search huggingface dataset:
ADDRESS ON DIETETICS.— MEDICAL FOOD ETHICS NOW AND TO COME.
Authors: EPHRAIM CUTTER
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-644 Stent thrombosis rates of the biodegradable polymer biolimus-eluting stent versus the durable polymer everolimus-eluting stent in all-comers undergoing PCI: A pooled analysis of the COMPARE II and NEXT trials at 1 year
Authors: Pieter C. Smits, Georgios J. Vlachojannis, Ken Kozuma, Masahiro Natsuaki, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2014)
Arthritis
Authors: Jack Edeiken
Journal: JAMA (1975)

THE PRIMARY-CARE physician is usually the first to examine a patient with arthritis. He may not appreciate the seriousness of the disease, since its onset may be insidious, the symptoms trivial, and the roentgenographic changes absent. Roentgenograms of a joint are really inadequate for visualizing the structures primarily involved in arthritis. The "joint space" is not a space at all, but contains the cartilage and synovia. Since the density of these structures approaches water density, their morphologic state cannot be discerned roentgenologically, and inflammation and destruction may be invisible. Thus, symptoms and clinical findings may long antedate the roentgenographic changes. After sufficient cartilaginous destruction has occurred, the joint finally narrows. The decreased joint space may be the first roentgenographic sign of the disease, but by this time irreparable damage has been done. Secondary erosive destruction of the adjacent bone also occurs at a late stage. Conversely, in some patients roentgenographic
Do treatment protocols improve end results?
Authors: M. McCarthy
Journal: BMJ (1989)

except in a hope that domiciliary fetal monitoring will promote more rational and convenient moni- toring policies.56We agree that there is a risk of overuse,4 and we are sure the debate on the value of antenatal cardiotocographs and the mission to deliver healthy babies should continue in the widest context.Meanwhile, we fully support any call for further evaluation of domiciliary fetal monitoring, and we have recently embarked on a major collaborative research programme in the south Wales valleys.This new application is potentially useful and deserves a fair hearing.
Cause of Hematic Cysts of the Orbit: Increased Fibrinolysis and Immunohistologic Expression of Tissue Plasminogen Activator
Authors: Koichi Yoshikawa, Hirosuke Fujisawa, Koji Kajiwara, Masami Fujii, Shoichi Kato, Tatsuo Akimura, Sadahiro Nomura, Toshikazu Gondo, Michiyasu Suzuki
Journal: Ophthalmology (2008)
Prevalence of Body Dysmorphic Disorder in a Community Sample of Women
Authors: Michael W. Otto, Sabine Wilhelm, Lee S. Cohen, Bernard L. Harlow
Journal: American Journal of Psychiatry (2001)

In a large population-based study, the authors examined the prevalence and correlates of body dysmorphic disorder, a debilitating and chronic condition characterized by an imagined defect in appearance.Rates and diagnostic correlates of body dysmorphic disorder were examined by using data from the Harvard Study of Moods and Cycles. This study used in-person structured clinical interviews to characterize the diagnostic status of a population-based, cross-sectional sample of 318 depressed and 658 nondepressed women between the ages of 36 and 44 who were selected from seven Boston metropolitan area communities.The presence of body dysmorphic disorder was significantly associated with the presence of major depression and anxiety disorders. The authors estimated the overall point prevalence of body dysmorphic disorder as 0.7% in women in this age range in the community.The authors found that the presence of body dysmorphic disorder was linked to the presence of major depression and anxiety disorders, which is similar to findings in clinical studies. Their estimate of the point prevalence of body dysmorphic disorder is consistent with data from a community-based sample of Italian women and suggests a prevalence similar to that of other serious psychiatric disorders in women (e.g., schizophrenia and drug abuse and dependence). These prevalence data encourage the further development of treatment options for this debilitating condition.
The cytokine network in asthma and chronic obstructive pulmonary disease
Authors: Peter J. Barnes
Journal: Journal of Clinical Investigation (2008)

Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory diseases of the airways. They both cause airway narrowing and are increasing in incidence throughout the world, imposing enormous burdens on health care. Cytokines play a key role in orchestrating the chronic inflammation and structural changes of the respiratory tract in both asthma and COPD and have become important targets for the development of new therapeutic strategies in these diseases.
Screening for Thyroid Dysfunction: Which Test Is Best?-Reply
Authors: Carole A. Spencer
Journal: JAMA (1993)

In Reply.  —Our letter 1 was written to accurately reflect optimal practice guidelines for the clinician as currently recommended by the ATA. The letter was prompted by a need to disseminate information as to the diagnostic impact of recent improvements in TSH assay sensitivity on optimal thyroid test selection. In the opinion of our experts, other recent guidelines 2 not fully utilizing the newer TSH assays do not reflect optimal practice, particularly since the role of TSH measurement in detection of subclinical thyroid dysfunction and in monitoring and adjusting levothyroxine therapy is given inadequate recognition.  We would not argue with Helfand and Schmittner that published studies do not justify conclusions that TSH is the best initial test in all clinical  Indeed, our letter clearly takes the position that no test is best in all clinical situations. However, the well-established log/linear relationship between TSH and FT 4 I dictates that
Hyperproduction of erythropoietin in nonanemic lead-exposed children.
Authors: P Factor-Litvak, V Slavkovich, X Liu, D Popovac, E Preteni, S Capuni-Paracka, S Hadzialjevic, V Lekic, N LoIacono, J Kline, J Graziano
Journal: Environmental Health Perspectives (1998)

Lead (Pb) poisoning has numerous effects on the erythropoietic system, but the precise mechanism whereby high dose exposure causes anemia is not entirely clear. We previously reported that Pb exposure is associated with depressed serum erythropoietin (EPO) in pregnant women residing in a Pb mining town and in a nonexposed town in Kosovo, Yugoslavia. In a prospective study, we tested the hypothesis that blood Pb concentration (BPb) may be associated with depressed EPO in children. BPb, hemoglobin (Hgb), and serum EPO were measured at ages 4.5, 6.5, and 9.5 years in 211, 178, and 234 children, respectively. At 4.5 years of age, mean BPbs were 38.9 and 9.0 microg/dl in the exposed and nonexposed towns, respectively; BPbs gradually declined to 28.2 and 6.5 microg/dl, respectively, by age 9.5 years. No differences were found in Hgb at any age. At age 4. 5 years, a positive association between BPb and EPO (beta = 0.21; p = 0.0001), controlled for Hgb, was found. The magnitude of this association declined to 0.11 at age 6.5 years (p = 0.0103) and 0.03 at age 9.5 years (p = 0.39). These results were confirmed using repeated measures analyses. We concluded that in Pb-exposed children, the maintenance of normal Hgb requires hyperproduction of EPO. With advancing age (and continuing exposure), this compensatory mechanism appears to be failing, suggesting a gradual loss of renal endocrine function due to Pb exposure.
The AMA, Chiropractic, and Judge Getzendanner's Injunction
Authors: Carl F. Needles
Journal: JAMA (1988)

<h3>To the Editor.</h3> —Mr Johnson's<sup>1</sup>critique of Judge Getzendanner's<sup>2</sup>ruling does not go far enough. What the judge has done is to penalize the American Medical Association (AMA) because it allegedly tried to deprive the plaintiffs of their rights under the guarantees of free speech and free enterprise and thereby injured them economically. She was unable to see that a profession that exploits superstition, prejudice, and other human frailties for profit may deserve a boycott. She does not see that a therapeutic maneuver can be effective without having scientific merit. She does not see that a boycott does not eliminate chiropractic; rather, it prevents AMA members from abetting chiropractic. When she says that "the AMA decided to contain and eliminate chiropractic as a profession," she is seeing something that isn't there. This injunction needs to be countered on medical as well as legal grounds.
Inducible Ventricular Tachycardia Due to Dermatomyositis-Related Cardiomyopathy in the Era of Implantable Cardioverter-Defibrillator Therapy
Authors: Polychronis Dilaveris, Panagiota Pietri, Dimitris Tsiachris, Konstantinos Gatzoulis, Christodoulos Stefanadis
Journal: Circulation (2012)
Evaluation of Urinary Level of NMP22 as a Diagnostic Marker for Stage pTa-pT1 Bladder Cancer: Comparison with Urinary Cytology and BTA Test
Authors: Alberto DelNero, Nicola Esposito, Anna Curr&ograve;, Davide Biasoni, Emanuele Montanari, Barbara Mangiarotti, Alberto Trinchieri, Gianpaolo Zanetti, MariaPia Serrago, Enrico Pisani
Journal: European Urology (1999)
Alcohol use disorders identification test has bias
Authors: Rahul Rao
Journal: BMJ (2006)

One-time general consent for research on biological samples Opt out system for patients is optimal and endorsed in many countriesEditor-Wendler's valuable overview of empirical studies of patients' preferences about the use of residual (leftover) tissue for research is not complete. 1 The discussion has already been settled by legislation in many countries.In 2004 the Danish act on patient rights was amended with an opt out system for using residual tissue for research.In 2004 the US Office for Human Research Protections (OHRP) issued guidance that research on residual tissue which is anonymous to the researcher is not human subject research and therefore the tissue can be used without consent. 2Earlier the Dutch Federation of Medical Research Societies' code of conduct on research with residual tissue drafted with patients' organisations had an opt out system for research on samples anonymous to the researcher. 3 In the recent UK Human Tissue Act no form of consent is needed for the use of fully anonymous or coded (or linked) residual tissue that is anonymous to the researcher, provided that an ethical review board has permitted the study.The more restrictive provisions in the original bill were amended also because of pressure from patient groups afraid that research to their benefit would be hampered by the proposed consent system.Wendler emphasises autonomy and argues that one-time consent protects the autonomy of individuals and protects them from serious risks.There are two major arguments against this.Firstly, autonomy should be balanced against other values such as the interests of patients who might benefit from this research. 4 Secondly, autonomy as such cannot protect individuals from risks but only from risks they do want to carry.Research on residual tissue, whether anonymous or anonymously used and being coded, does not carry any risks to individuals.Ethical review boards should oversee that sufficient measures have been taken to ensure that the samples used in research remain anonymously used.It should be possible to enrich data from tissue research with patient data.Fully anonymising samples, as suggested by Wendler, is a waste of valuable information.
DEMONSTRATION OF THE SEQUENTIAL DEVELOPMENT OF VACCINIAL ANTIGENS AND VIRUS IN INFECTED CELLS: OBSERVATIONS WITH CYTOCHEMICAL AND DIFFERENTIAL FLUORESCENT PROCEDURES
Authors: Philip C. Loh, John L. Riggs
Journal: The Journal of Experimental Medicine (1961)

Virus-induced alterations in vaccinia virus-infected HeLa cells have been followed by immunofluorescent and cytochemical techniques. In a time sequence study, infected cells show an early increase in cytoplasmic RNA content, followed by appearance of centers of viral DNA synthesis in the cytoplasm. The centers of synthesis were detected at 4 hours post infection, with the acridine orange fluorochrome stain as compared to 6 hours with Feulgen and methyl green-pyronin stains. Marginal fragmentation of the inclusion bodies was seen at 8 to 10 hours post infection, and appears to coincide with the first increase in cell-associated virus. With the immunofluorescent technique, it was found that the LS antigen of the virus can be detected at about 4 hours post infection. This is followed at 5 to 6 hours post infection by the appearance of the NP antigen. Both antigens are found only in the cytoplasm, and precede the appearance of the infective particle. The HA antigen, a by-product of virus-cell interaction, is not seen until about 10 hours post infection; that is, several hours after the appearance of both the LS and NP antigens, and only after the appearance of mature virus. The successful application of the use of two immune sera, each labeled with a different fluorescent dye for the simultaneous visualization of two antigens within a cell, is reported. Using this technique, the sites of LS and NP antigen synthesis, were easily differentiated. The intimate mixing of the two antigens at a later stage appears to coincide with the fragmentation of the inclusion body and the first detectable increase in cell-associated virus. The evidence obtained strongly suggests that the typical inclusion body observed in vaccinia-infected cells is composed mainly of the NP antigen.
Preventing Tobacco Purchases by Underage Youths
Authors: Greg Hewett
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bronchiectasis and oligospermia: two families.
Authors: M Greenstone, A Newman-Taylor, P Cole
Journal: Thorax (1986)

Bronchiectasis and oligospermia: two families SIR,-We were interested to read the paper by Dr Pamela B Davis and colleagues describing the association of oligospermia and bronchiectasis (May 1985;40:376-9) in two fam- ilies, which they suggest is a new syndrome.It is, however, open to question whether the condition described really is new or, as seems possible, details two further families with primary ciliary dyskinesia (PCD).The clinical histories, including neonatal pneumonia, lifelong productive cough, and recurrent otitis media requiring repeated gromet insertion, against a background of general good health and reasonable lung function, are typical of primary ciliary dys- kinesia.It is unfortunate that no measurements of nasal or
Gravlee Jet Irrigator as a Screening Method?-Reply
Authors: Leo B. Twiggs
Journal: JAMA (1976)

The favorable results Drs Casey and Madden experienced with the Gravlee jet irrigation technique are to be commended. Certainly, strict control of all variables will increase the reliability of this technique. As the correspondents suggest, it is possible that our results could have been improved by varying the processing method; however, our pathology department tested and then discarded the permeable membrane filter (Millipore) technique, as did Dr Gravlee,<sup>1</sup>since it added little information. In our study, collection of gross tissue fragments was accomplished by rinsing the tip of the irrigator in the fixing solution as a terminal step in gathering the specimen. It is perhaps teleologic that the onset of symptoms is directly proportional to the extent of the disease. Thus, the accuracy of a given technique would increase in patients with symptoms and presumably more advanced lesions. Possibly, this is not the case. On the other hand,
Complications of Intrahospital Transport in Critically III Patients
Authors: SIDNEY S. BRAMAN
Journal: Annals of Internal Medicine (1987)

To determine the frequency of hemodynamic and respiratory complications during movement within the hospital, we conducted a prospective study involving 36 critically ill, ventilator-dependent patients who needed procedures done outside the intensive care unit. During the first 20 transports, patients received ventilation through a manual resuscitation bag. Arterial blood gas measurements showed frequent changes from baseline with alterations in PCO2 ( > 10 torr) or pH ( > 0.05) occurring on 14 occasions. In a subsequent study, 16 patients received ventilation during transit with the aid of a portable mechanical ventilator. Although 6 patients showed changes in arterial blood gas values, mean changes in PCO2 and pH were significantly less than in the group that received manual ventilatory support (p < 0.01). Hemodynamic complications of hypotension and cardiac arrhythmia showed a significant correlation with disturbances in arterial blood gases (p < 0.05). Although limited by the lack of a control period, this study shows that the transport of critically ill patients may result in severe hemodynamic complications; it also suggests that these complications might be prevented by more careful monitoring of ventilation.
THE NEW DIETETIC TREATMENT OF DIABETES MELLITUS
Authors: P. J. Cammidge
Journal: BMJ (1917)

Every effort is made to retain fragments of bone at the seat of a compound fracture, as, if necrosis can be avoided, these fragments play an important part in the subsequent union of the bone.Plating a fracture is out of the ques- tion until the woound is hlealed, and even tllen must be delayed some time until tlle health of the patient lhas improved and therb is less rislk of operation stirringc up a quiescent local septic focus.Fragments of metal in the bone are no (letriment to plating so long as they are causing no irritation.In one case of non-union of a frac-
Interactions Between Physicians and the Health Care Technology Industry
Authors: Robert M. Tenery, Jr
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and tolerability of three different doses of oral pimecrolimus in the treatment of moderate to severe atopic dermatitis: a randomized controlled trial
Authors: K. Wolff, C. Fleming, J. Hanifin, K. Papp, S. Reitamo, M. Rustin, N. Shear, W. Silny, N. Korman, I. Marks, R. Cherill, S. Emady-Azar, C. Paul
Journal: British Journal of Dermatology (2005)

Background Adult atopic dermatitis (AD) can seriously affect quality of life of patients and their families, and patients' disease is frequently not satisfactorily controlled with topical therapy. There is a need for alternatives to topical treatment in patients with moderate to severe AD. Objectives To investigate the efficacy and safety of oral pimecrolimus, and to determine the response to three different doses in the treatment of AD. Methods In a double‐blind, placebo‐controlled, parallel‐group, dose‐finding study, patients with moderate to severe AD were randomized to receive either placebo, or oral pimecrolimus 10, 20 or 30 mg twice daily. The study consisted of a pretreatment phase, a 12‐week double‐blind treatment phase, and a 12‐week post‐treatment phase. Results In total, 103 patients were randomized. A clear, dose‐dependent therapeutic effect of pimecrolimus treatment was observed, with a statistically significant onset of efficacy at week 2 and the greatest reduction from baseline of the Eczema Area and Severity Index of 66·6% at week 7 in the 30 mg twice daily dose group. Oral pimecrolimus was well tolerated and there were no signs of nephrotoxicity or the induction of hypertension. Conclusions These data demonstrate the clinically relevant efficacy and short‐term safety of oral pimecrolimus in adults with moderate to severe AD. Longer‐term studies in larger cohorts are now required.