tbuckley/cabot-search huggingface dataset:
Cimetidine in Eosinophilie Fasciitis
Authors: Herson Serge
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 September 1990Cimetidine in Eosinophilie FasciitisHerson Serge, MD, Sabine Brechignac, MD, Godeau Pierre, MDHerson Serge, MDSearch for more papers by this author, Sabine Brechignac, MDSearch for more papers by this author, Godeau Pierre, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-5-412_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors: Eosinophilic fasciitis is a recently discovered syndrome, first described by Shulman in 1974. Corticotherapy is the usual treatment, providing dramatic improvement in induration and swelling. Some papers (1-3) recently reported that Cimetidine is an effective treatment.We used Cimetidine in six patients with this syndrome with no benefit. There were three men and three women (mean age, 44 years; range, 32 to 69 years at time of diagnosis). The diagnosis of eosinophilic fasciitis was supported in these patients by the rapid onset of painful edema with subcutaneous induration of the limbs and trunk, sparing the face...References1. SolomonBarlandRifkin GPH. Eosinophilic fasciitis responsive to cimetidine. Ann Intern Med. 1982;97:547-9. LinkGoogle Scholar2. LasoPastorDe Castro FIS. Cimetidine and eosinophilic fasciitis. Ann Intern Med. 1983;98:1026. LinkGoogle Scholar3. Garcia-MorteoMaldonado-CoccoBarreiraBarcelo OJJH. Cimetidine and eosinophilic fasciitis. Ann Intern Med. 1984;100: 318-9. LinkGoogle Scholar4. GriswoldAlessiBadgerPosteHanna DSAGN. Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists. J Immunol. 1984;132:3054-7. MedlineGoogle Scholar5. Loftin E. Cimetidine and eosinophilic fasciitis. Ann Intern Med. 1983;98:111-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Université Pierre et Marie Curie 75651 Paris France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEosinophilic fasciitis: demographics, disease pattern and response to treatment: report of 12 cases and review of the literature 1 September 1990Volume 113, Issue 5Page: 412-413KeywordsEdemaInflammation ePublished: 1 December 2008 Issue Published: 1 September 1990 PDF downloadLoading ...
Bioluminescence imaging allows measuring CD8 T cell function in the liver
Authors: Dirk Stabenow, Marianne Frings, Christina Trück, Katja Gärtner, Irmgard Förster, Christian Kurts, Thomas Tüting, Margarete Odenthal, Hans‐Peter Dienes, Karin Cederbrant, Ulrike Protzer, Percy A. Knolle
Journal: Hepatology (2010)

In vivo evaluation of CD8 T cell effector (cytotoxic T lymphocyte [CTL]) function in peripheral organs such as the liver is currently not possible but would greatly improve our understanding of local immune regulation, because simple determination of antigen-specific CTL numbers does not predict the outcome of immune responses. In particular, measurement of alanine aminotransferase serum levels is not sensitive enough to detect T cell immunity against low numbers of target hepatocytes. We developed a procedure that detects virus-specific effector function of CTLs in the liver after simultaneous adenoviral transfer of reporter and immune target genes into hepatocytes, followed by bioluminescence imaging of reporter genes. Bioluminescence imaging enabled detection of as few as 10,000 infected hepatocytes in vivo, and even more importantly, quantification of antiviral effector function of as few as 50,000 CTLs. Conclusion: Our results provide evidence that low numbers of antigen-specific CTLs are sufficient to control viral gene expression and eliminate viral infection from hepatocytes. The experimental system established here is a highly sensitive method to simultaneously detect viral infection of hepatocytes and to quantify antiviral CTL function in the liver in vivo and will help in characterizing principles of hepatic immune regulation. (HEPATOLOGY 2010;51:1430–1437)
Marihuana and the Diabetic Coma
Authors: James E. Hughes
Journal: JAMA (1970)

Marihuana ingestion by a 21-year-old man was followed by severe diabetic ketoacidosis. Following oral ingestion of marihuana, nausea, vomiting, diuresis, and an elevation of blood glucose level have previously been noted. It is speculated that when the stress of marihuana ingestion is greater than the adaptive capacity of the glucose-regulating system, diabetic ketoacidosis might evolve.
THE WASSERMANN REACTION IN SCARLET FEVER PATIENTS
Authors: GROVER E. CHRISTENSEN
Journal: JAMA (1923)

The idea that the Wassermann reaction may be positive because of scarlet fever, independently of syphilis, is apparently current. Having had a desire to learn more as to the truth of such an idea, I have been prompted to make this investigation. The purpose of this report is briefly to summarize the literature bearing on this topic, and to give the results of my own investigations.  At a time when the Wassermann reaction was first beginning to attract attention—before the technic was well standardized, and when many observers were publishing many sorts of conclusions based on their faulty work—there appeared an article by Much and Eichelberg 1 to the effect that this reaction was positive in a large proportion of patients with scarlet fever. Appearing at the time it did, this article naturally made a more profound impression than it would have made if it had appeared later. The impression
UroVysion Compared with Cytology and Quantitative Cytology in the Surveillance of Non–Muscle-Invasive Bladder Cancer
Authors: Paula M.J. Moonen, Gerard F.M. Merkx, Pim Peelen, Herbert F.M. Karthaus, Dominique F.C.M. Smeets, J. Alfred Witjes
Journal: European Urology (2006)
Abstract OT1-1-01: A phase II study of neoadjuvant epirubicin/cyclophosphamide (EC) followed by weekly nanoparticle albumin-bound paclitaxel with or without trastuzumab for node-positive breast cancer
Authors: A Hirano, A Hattori, M Kamimura, K Ogura, N Kim, Y Setoguchi, F Okubo, H Inoue, N Jibiki, R Miyamoto, J Kinoshita, K Kimura, M Fujibayashi, T Shimizu
Journal: Cancer Research (2012)

Abstract Background: Paclitaxel is considered standard treatment for metastatic breast cancer (MBC) and is often used as adjuvant and neoadjuvant chemotherapy for patients with early-stage disease. Conventional paclitaxel requires solvents such as polyoxyethylated castor oil; however, such solvents are associated with toxicity including peripheral neuropathy and hypersensitivity reaction. Moreover, the use of the drug requires special tubing and in-line filters. Therefore, nanoparticle albumin-bound paclitaxel (nab-PTX) requiring no solvent has been developed. Nab-PTX was effective in patients with MBC and as a neoadjuvant therapy. A comparison between weekly and triweekly nab-PTX suggested that weekly nab-PTX was superior in progression-free survival. Trial design: This is a phase II trial to evaluate the efficacy and toxicity of neoadjuvant epirubicin/cyclophosphamide (EC) (epirubicin/cyclophosphamide) followed by weekly nab-PTX with or without trastuzumab for node-positive breast cancer. Patients receive four cycles of epirubicin (90 mg/m2) and cyclophosphamide (600 mg/m2) every 3 weeks, followed by four cycles of nab-PTX (125 mg/m2) on days 1, 8 and 15 in a 28-day cycle. Fifteen cycles of trastuzumab (2 mg/kg, loading 4 mg/kg) are added to the nab-PTX regimen in HER2-positive patients every week. Eligibility criteria: Patients with histologically diagnosed invasive breast cancer based on a core needle biopsy of the T1-4 N1-3 without previous operation or chemotherapy are included in this trial. Eligible patients are aged between 20 years and 70 years with a performance status of 0 to 2 and adequate organ functions. Specific aims: The primary endpoint is the pathologic complete response (pCR) rate in the breast and axilla, and the secondary endpoints are the breast conserving rate, toxicities, feasibility and overall survival. Statistical methods: The sample size was calculated using the Simon method, with a type I error of 10% and a study power of 80%. 1. HER2-negative patients The expected rate of pCR was 25% and the required number of patients was estimated to be 33. 2. HER2-positive patients The expected rate of pCR was 50%, and the required number of patients was estimated to be 21. Present and target accrual: Patient accrual within two medical centers started in April 2011 with 20 patients being on study to date (2012, June 12). A total of 56 patients (22 are HER2-positive and 34 are HER2-negative) are planned to be enrolled in the trial. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr OT1-1-01.
Left Ventricular Diastolic Function in Hypertension and Role of Plasma Glucose and Insulin
Authors: A. Jain, G. Avendano, S. Dharamsey, A. Dasmahapatra, R. Agarwal, A. Reddi, T. Regan
Journal: Circulation (1996)

Background Experimental production of glucose intolerance has been associated with increased diastolic stiffness of the left ventricle, accompanied by interstitial fibrosis. Because carbohydrate metabolism is altered in hypertension, we undertook the present study to assess the relation of diastolic dysfunction in hypertension to plasma glucose and insulin concentrations. The latter are also affected by obesity. To facilitate this analysis, we studied moderately obese hypertensives. Elucidation of these relations was then sought in diabetic subjects. Methods and Results Subjects undergoing catheterization for chest pain were included in the study when significant coronary disease was not present. In groups 1 (lean), 2 (obese), 3 (lean hypertensive), and 4 (obese hypertensives), intraventricular pressures and volumes were determined. Fasting plasma glucose, insulin, hemoglobin AIC , and glucose tolerance were assessed. Basal ejection fraction and end-systolic wall stress were normal in the four groups. Chamber stiffness was significantly elevated in the hypertensives and was higher in group 4 than in group 3 ( P &lt;.05). Diastolic dysfunction was correlated with fasting blood glucose ( r =.69, P &lt;.006) but not with plasma insulin or left ventricular mass. Chamber stiffness was also increased in diabetics, with a larger effect in the obese. Conclusions Hypertension is associated with increased diastolic stiffness of the left ventricle, which is enhanced by moderate obesity, and abnormal carbohydrate metabolism. Experimentally and in humans, hypertension is associated with interstitial fibrosis of mycardium, the presumed basis for the diastolic dysfunction. Chamber stiffness in group 4 hypertensives was similar to that in the lean diabetics but less than that in the obese diabetics. Although the latter exhibited a correlation with plasma hemoglobin AIC , the large rise in stiffness suggests a potential role for growth factors in further alteration of myocardial composition.
Nine million Americans have lost health insurance in recession
Authors: B. Roehr
Journal: BMJ (2011)

An estimated nine million of the 13.7 million adult Americans who have lost their jobs in the current economic recession lost the health insurance coverage previously provided by their employer, warns a health insurance survey by the Commonwealth Fund, published on 16 March.

Adults earning less than 200% of the federal poverty level were much more likely to have become uninsured than those whose income was higher than this level (70% versus 42%). Adults in this lower income group were less likely to have gained coverage under a spouse’s health insurance plan or through other means (22% versus 29%). And they were much less likely to have been able to …
Abstract 307: EphB4 promotes or suppresses Ras/ERK pathway depending on cellular contexts: Implications for EphB4 as a cancer target
Authors: Zhan Xiao, Rosa A. Carrasco, Krista Kinneer, Darrin Sabol, Steve Coats, Bahija Jallal, David Tice
Journal: Cancer Research (2010)

Abstract EphB4 is a member of the Eph RTK family. Its classical role has been shown to act in neuronal guidance and mediate venal/arterial separation. In contrast to these more established roles, EphB4's function in cancer is controversial since both tumor promoting as well as tumor suppressing functions have been ascribed to it. Here we provide a vivid illustration of this intriguing dichotomy by showing that EphB4 activation resulted in inhibition of the Ras/ERK pathway in endothelial cells but induction of the same pathway in MCF-7 breast cancer cells. This was true if EphB4 was stimulated with ephrinB2, its natural ligand, or an EphB4-specific fully human monoclonal antibody. The reason for these dramatic differences is due to potential functional coupling of EphB4 to different downstream effectors. In HUVEC cells, the RNAi knockdown of p120 RasGAP, a Ras inhibitor, abrogated the inhibitory effect on Ras/ERK pathway. However, in MCF7 cells, RNAi knockdown of PP2A, which has been shown to activate the Ras/ERK pathway through removal of the inhibitory phosphorylation on c-Raf, negated EphB4-driven activation of the Ras/ERK pathway. This represents the first time a functional coupling between Eph receptor and PP2A has been established, and this interaction appears to confer activation but not suppression of an oncogenic pathway. Our study also demonstrates the caveats and potential challenges of targeting EphB4 for cancer therapy due to the presumed conflicting effects on cancer cell and endothelial cell compartments. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 307.
Diabetes and the Eye
Authors: A. R. Colwell
Journal: JAMA (1969)

This small, compact work summarizes the natural history and biochemical and pathological investigations of ocular disease in diabetes. Because of the increasing frequency of these complications, which produce blindness in 10,000 people annually in England and Wales alone, clinicians should find it valuable. Although only 7% of aphakia is caused by diabetic retinopathy, half the book is devoted to this problem. That its pathogenesis involves deposition of glycoprotein, causing thickening of the basement membrane, is suspected but still unproved. Since the disease correlates with the duration of diabetes, it must be considered part of the associated microangiopathy syndrome. Half of patients having malignant retinopathy die after five years, usually of renal disease. Two thirds of the patients with retinopathy subjected to pituitary ablation either show improved vision or their condition fails to deteriorate as rapidly as prior to surgery. Laser photocoagulation is now employed in treating new blood-vessel growth. A
The Missouri State Board of Health.
Authors: F. J. Lutz
Journal: JAMA (1894)

St. Louis, Mo., Oct. 26, 1894. <h3>To the Editor:</h3> —The Missouri State Board of Health at its meeting held in St. Louis on October 25, unanimously adopted the following resolution: "No medical college guilty of issuing a catalogue or prospectus in which are contained material misrepresentations concerning its teaching facilities, course of study or false representations in the list of students matriculated, or in attendance, shall be in good standing with this Board." Very respectfully,
Preload, contractility, and afterload as determinants of stroke volume during elevation of aortic blood pressure in dogs
Authors: B. BUGGE-ASPERHEIM, F. KIIL
Journal: Cardiovascular Research (1973)

Aortic blood pressure was raised at various end-diastolic volumes at high and low myocardial contractility, and after autonomic blockade. Elevation of aortic blood pressure elicited a stroke volume-increasing effect by raising end-diastolic volume (preload) and a stroke volume-reducing effect by raising afterload. Large end-diastolic volume and low myocardial contractility favoured a fall in stroke volume, whereas stroke volume rose during elevation of aortic blood pressure at high myocardial contractility, especially at small end-diastolic volume. The interactions of preload, contractility, and afterload on stroke volume are predictable from an analysis of ventricular function curves (relationship between stroke volume and end-diastolic volume).
Deaths from Electric Shock in 1962 and 1963
Authors: W. R. Lee
Journal: BMJ (1965)

During this century the number of deaths from electric shock has risen from 8 in 1901 to 154 in 1963 (Registrar-General, 1902-1964), and there is no indication that we have seen the end of this increase.That is not to say there has been a deterioration in electrical safety.When the number of deaths in each year is related to the amount of electricity supplied it wi be seen (Table I) that the number of fatalities per million kilowatt hours consumed has steadily fallen.Nevertheless, the steady rise in fatalities merits serious attention.TABLE I.-Incidence of Death, Consumption of Electricity, and Ratio of Deaths to Electricity Consumed (1901-62) Average Rates Average of Deaths to Average No.
Rationale for psychostimulants in ADHD
Authors: Alan Dugdale
Journal: BMJ (2005)

Evidence based medicine: does it make a difference? Use wiselyEditor-The term "evidence based medicine" entered the scientific lexicon only a little more than a decade ago. 1 What caused its remarkable spread, and what are the implications of its broad and rapid diffusion?The team that coined the term at first considered using the phrase "scientific medicine" but rejected it because it implied that other approaches were by definition unscientific. 2However, critics have argued that the term evidence based medicine carries a similar moral valence and linguistic slipperiness. 3 Who could argue against the notion of providing care that integrates individual clinical skill and the best external evidence? 4 Originally developed as a method for teaching medical residents, evidence based medicine is being applied ever more broadly to the organisation and delivery of medical services.Multiple stakeholders now seek to assume its mantle for purposes that often contradict its original intent.Managers, equating lack of evidence with lack of effectiveness, use it as a rationale for cutting services.Industry generates evidence of questionable quality to promote its products.Medical researchers come to believe that they hold a monopoly on generating and interpreting evidence.Evidence based medicine, developed as a means of taming the unscientific and messy world of clinical practice, has itself entered the unscientific and messy world of politics. 5ike any technology, evidence based medicine carries risks and benefits and can be used appropriately or inappropriately.Overly inclusive definitions threaten to deprive the term of meaning, and unchecked use increases the risk of misuse.In the past decade, evidence based medicine has contributed much to how we teach, deliver, and think about clinical services.In the coming decade, we must continue to ensure that it is not only used widely but wisely.
Re: Gyorgyike Soos, Ioannis Tsakiris, Janos Szanto, Csaba Turzo, P. Gabriel Haas and Balazs Dezso. The prevalence of prostate carcinoma and its precursor in Hungary: an autopsy study. Eur Urol 2005;48:739–44
Authors: K. Stamatiou, A. Alevizos, A. Mariolis, F. Sofras
Journal: European Urology (2006)
Intravascular Ultrasound Findings After Successful Primary Angioplasty for Acute Myocardial Infarction: Predictors of Abrupt Occlusion
Authors: Masashi Iwabuchi, Seiichi Haruta, Atsushi Taguchi, Yoshito Ichikawa, Tomoo Genda, Satoshi Katai, Takeshi Imaoka, Yosihito Shimizu, Mafumi Owa
Journal: Journal of the American College of Cardiology (1997)
Health in Africa: Time to wake up to cancer's toll
Authors: Scott A Murray, Elizabeth Grant, Faith Mwangi-Powell
Journal: BMJ (2005)

Time to wake up to cancer's tollEditor-As exemplified by your theme issue on Africa of 1 October, cancer has remained comparatively neglected in Africa although increasingly prevalent: 70% of people with cancer live in the economically developing world, where by 2020 the annual death toll is predicted to reach 20 million. 1 In sub-Saharan Africa measures to prevent cancer emphasised in the developed world-such as smoking cessation and screening-are not nationally adopted.One third of African cancers are preventable, but the influence of tobacco companies with mass media advertising and high crop payments is real.Traditional cancers, such as gastric and hepatocellular carcinoma, and newer cancers, such as lung cancer, breast cancer, and AIDS related Kaposi's sarcoma, are increasing in incidence. 2 3 Patients' expectations for oncological treatment are low in Africa.Lack of money, or a concern not to place their family in debt, prevents many from seeking medical help. 4 Lack of awareness of predisposing factors, warning symptoms or signs of cancer, or treatment options mean that patients present late.Cost and difficulty of travel over rough terrain also discourage service use.After diagnosis patients may tend to look for peace of mind and spiritual comfort rather than a physical cure.In Africa disease modifying cancer treatment and basic control of symptoms are largely absent.Even when analgesia is available, patients with cancer may experience severe and inadequately managed pain, as health professionals underprescribe strong analgesics, fearing drug dependency. 5 Individual sub-Saharan countries cannot tackle the challenges of cancer in isolation.A new, cooperative approach and research base are being advocated for preventing, treating, and palliating cancer to bridge the gap between developed and developing nations.
Pre-immigration screening for pulmonary tuberculosis
Authors: Z. Mor, Y. Lerman, A. Leventhal
Journal: European Respiratory Journal (2009)

Tuberculosis (TB) screening policies are influenced by the structure of the national TB programme, the existing financial resources, the expertise of available professionals and the sense of apprehension expressed by the local population in the host country.The aim of our study was to evaluate the unique screening process performed in Ethiopian immigrants arriving in Israel, and to share our experience with the ERJ's readers.
Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries
Authors: B Chen, W-L Zhao, J Jin, Y-Q Xue, X Cheng, X-T Chen, J Cui, Z-M Chen, Q Cao, G Yang, Y Yao, H-L Xia, J-H Tong, J-M Li, J Chen, S-M Xiong, Z-X Shen, S Waxman, Z Chen, S-J Chen
Journal: Leukemia (2005)
DIABETOGENIC, THYROTROPIC, ADRENOTROPIC AND PARATHYROTROPIC FACTORS OF THE PITUITARY
Authors: J. B. COLLIP
Journal: JAMA (1935)

<h3>Note.—</h3> This article and the articles in the previous issues ofThe Journalare part of a series published under the auspices of the Council on Pharmacy and Chemistry. Other articles will appear in succeeding issues ofThe Journal. When completed, this series will be published in book form.—Ed. <h3>I. DIABETOGENIC SUBSTANCE</h3> Numerous observations made both in the clinic and in the laboratory are to be found in the literature of the last few years which indicate either directly or indirectly that the pituitary gland may influence definitely the metabolism of both carbohydrate and fat; for this reason there has been a growing conviction that the pituitary has some endocrine relationship with the pancreatic islets or their secretion. Borchardt<sup>1</sup>noted the frequent occurrence of glycosuria in acromegaly, and this was confirmed by Goetsch, Cushing and Jacobson.<sup>2</sup>More recently, Houssay<sup>3</sup>and Eidelsberg<sup>4</sup>have called attention to the frequent occurrence of