Chlorpromazine and Immunologic Considerations of Schizophrenia
Authors: G. DAVIS GAMMON
Journal: Annals of Internal Medicine (1980)

Letters1 March 1980Chlorpromazine and Immunologic Considerations of SchizophreniaG. DAVIS GAMMON, M.D., HISHAM HAFEZ, M.D., JOHN P. DOCHERTY, M.D.G. DAVIS GAMMON, M.D.Search for more papers by this author, HISHAM HAFEZ, M.D.Search for more papers by this author, JOHN P. DOCHERTY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-441_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Phenothiazines have had a well-known salutory impact on the treatment of psychosis. Unfortunately, a large number of schizophrenic patients remain chronically psychotic despite phenothiazine treatment. Assuming an essential similarity of neurochemical pathology, a number of mechanisms have been proposed to account for this refractoriness to drug treatment: noncompliance (1), poor absorption from the gut (2), modified receptor sensitivity (3), and accelerated liver metabolism (4).Zarrabi and colleagues (5) report an interesting and useful study suggesting a speculation that might shed further light in the problem of phenothiazine resistance in the treatment of schizophrenia. These authors showed a...References1. GITTELMAN-KLEINKLEIN RD. Long-term effects of "antipsychotic" agents. In: EFRON DH, COLE JO, LEVINE J, WITTENBORN JR, eds. Proceedings of the Sixth Annual Meeting of the American College of Neuropsychopharmacology. Washington, D.C.: U.S. Government Printing Office; 1968;1119-54. Google Scholar2. CURRYD'MELLOMOULD SAG. Destruction of chlorpromazine during absorption in the rat in vivo and in vitro. Br J Pharmacol. 1971;42:403-11. CrossrefMedlineGoogle Scholar3. FRIEDHOFFALPERT AM. Receptor sensitivity modification. In: Psychopharmacology: A Generation of Progress. LIPTON, MA, KILLAM K, DIMASCIO A. New York: Raven; 1978:797-801. Google Scholar4. LOGACURRYLADER SSM. Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man. Br J Pharmacol. 1975: 2:197-208. CrossrefGoogle Scholar5. ZARRABIZUCKERMILLER MSF. Immunologic and coagulation disorders in chlorpromazine-treated patients. Ann Intern Med. 1979;91:194-9. LinkGoogle Scholar6. AMKRAUTSOLOMONALLANSMITHMCCLELLANRAPPAPORT AGMBM. Immunoglobulins and improvement in acute schizophrenic reaction. Arch Gen Psychiat. 1973;28:673-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: G. DAVIS GAMMON, M.D.; HISHAM HAFEZ, M.D.; JOHN P. DOCHERTY, M.D.Affiliations: Department of Psychiatry Yale University School of Medicine New Haven, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntinuclear and gastric parietal cell autoantibodies in schizophrenic patients 1 March 1980Volume 92, Issue 3Page: 441-442KeywordsChlorpromazineDrug absorptionDrug metabolismDrugsLiverPhenothiazineSchizophrenia ePublished: 1 December 2008 Issue Published: 1 March 1980 PDF downloadLoading ...