tbuckley/cabot-search huggingface dataset:
Abstract 1203: Targeting FGFR4 in colorectal cancer cells
Authors: Christine Heinzle, Zeynep Erdem, Gudrun Sonvilla, Stefan Stättner, Josef Karner, Martin Klimpfinger, Bettina Grasl-Kraupp, Klaus Holzmann, Michael Grusch, Walter Berger, Brigitte Marian
Journal: Cancer Research (2012)

Abstract Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the regulation of cell proliferation, differentiation and survival as well as tumor development and therefore constitute prominent targets for cancer therapy. Over-expression of FGFR4 has been described in various cancer types and was also related to tumor aggressiveness. Reports concerning the role of FGFR4 in colorectal cancer (CRC) are still under dispute. In our study we found FGFR4 expression to be significantly up-regulated in human CRC tissue compared to normal mucosa. CRC cell line models over-expressing FGFR4 were created by transfecting SW480, HCT116 and HT29 colon carcinoma cells with a FGFR4 expression vector. This resulted in an increase of cell proliferation and colony formation under standard tissue culture conditions and colony outgrowth in soft agar was stimulated. In xenografted SCID mice tumor growth was significantly increased by FGFR4 over-expression. siRNA mediated knock down of FGFR4 in the high FGFR4 expressing cell lines HCT116 and HT29 resulted in decreased cell proliferation, viability and colony outgrowth in 2-dimensional growth assays. Additionally a dominant negative FGFR4 adenoviral construct inhibited 3-dimensional anchorage independent growth and suppressed tumor growth in vivo almost completely. Ongoing experiments analyze the effects of a soluble FGFR4 variant on 2-dimensional and 3-dimensional growth. FGFR4 up-regulation resulted in activation of survival pathways via FRS2 and PI3K leading to phosphorylation of GSK3β and S6. Signaling effects by blockage of FGFR4 dependent signaling via siRNA and the dominant negative adenoviral construct are currently being investigated. Based on our results we identified the FGFR4 as an important oncogene in the carcinogenesis which is involved in the tumor growth regulation of CRC in vitro and in vivo. Consequently FGFR4 should be regarded as a new therapeutic target in CRC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1203. doi:1538-7445.AM2012-1203
Noninvasive assessment of liver fibrosis
Authors: Stella M. Martínez, Gonzalo Crespo, Miquel Navasa, Xavier Forns
Journal: Hepatology (2010)

Liver biopsy has long been an important tool for assessing the degree of liver fibrosis. Information on the presence and degree of liver fibrosis is useful before making therapeutic decisions or predicting disease outcomes. The need to stage liver fibrosis, however, should decrease as treatment options become more successful (as has occurred with viral hepatitis). In recent years, noninvasive tests have demonstrated a reasonable ability to identify significant fibrosis, cirrhosis in particular, nor is it surprising that liver disease specialists and patients favor a noninvasive approach. However, only those tests with the highest diagnostic accuracy, cost-effectiveness, and availability should be implemented. Apart from their diagnostic accuracy, the potential ability of these tests to predict disease outcomes (a more relevant endpoint) should be compared with that of liver biopsy. Indeed, the use of a standardized system to evaluate the utility of biomarkers would facilitate their implementation in clinical practice. (Hepatology 2011.)
Rabbit antithymocyte globulin and cyclosporine as first-line therapy for children with acquired aplastic anemia
Authors: Yoshiyuki Takahashi, Hideki Muramatsu, Naoki Sakata, Nobuyuki Hyakuna, Kazuko Hamamoto, Ryoji Kobayashi, Etsuro Ito, Hiroshi Yagasaki, Akira Ohara, Akira Kikuchi, Akira Morimoto, Hiromasa Yabe, Kazuko Kudo, Ken-ichiro Watanabe, Shouichi Ohga, Seiji Kojima
Journal: Blood (2013)
Effect of Diphenylhydantoin on Left Ventricular Function in Patients with Heart Disease
Authors: ALAN D. LIEBERSON, RICHARD R. SCHUMACHER, RICHARD H. CHILDRESS, DANIEL L. BOYD, JOHN F. WILLIAMS
Journal: Circulation (1967)

The effect of 250 mg of diphenylhydantoin, administered intravenously, on left ventricular function was determined during cardiac catheterization in nine patients with heart disease. Five minutes after drug administration, left ventricular end-diastolic pressure rose in each patient from an average of 6.0 mm Hg to 10.0 mm Hg. Concurrently, stroke work and stroke power indices decreased in each patient by an average of 22.0% and 22.2%, respectively. Stroke volume index decreased in seven patients and maximum left ventricular dp/dt fell in eight patients. Over the next 25 minutes, all parameters returned to control values. Cardiac index was unchanged, whereas generally small and insignificant changes were observed in heart rate and systemic arterial pressure throughout the study. Although this study has demonstrated that diphenylhydantoin depresses myocardial function, the effect may have limited clinical significance since it was relatively short-lived and did not reduce cardiac output or greatly elevate ventricular end-diastolic pressure. Furthermore, the absence of a significant systemic hypotensive effect is of distinct clinical importance.
Stiff: The Curious Lives of Human Cadavers
Authors: J. H. Davis
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of cimetidine on upper gastrointestinal bleeding after renal transplantation: a prospective study.
Authors: S Walter, J Thorup Andersen, U Christensen, H Lokkegaard, H Kjersem, J I Dahlager Jorgensen, F Stadil
Journal: BMJ (1984)

In 97 consecutive patients undergoing renal transplantation the incidence of upper gastrointestinal bleeding was registered over 180 days after allocation to treatment with either cimetidine or placebo. Bleeding episodes occurred in 12 patients, 11 of whom were receiving placebo and only one cimetidine (p less than 0.01). All bleeding episodes occurred during the first month after allotransplantation. Treatment with cimetidine did not lead to an increased incidence of rejection of the allograft. It is concluded that cimetidine is effective and safe in protecting against upper gastrointestinal bleeding after renal transplantation.
Inhibition Experiments with Solid Phase Mite or Epithelia in House Dust Hypersensitivity
Authors: G. Pauli, J. C. Bessot, R. Thierry
Journal: Allergy (1979)

The present study was undertaken to verify that mites are not the only allergens in house dust extracts and that other allergens such as cat epithelia can also be responsible for house dust hypersensitivities detected both by house dust skin tests and house dust RAST studies. In order to determine whether mite or epithelia fixed on a solid phase could remove not only the IgE antibodies reactive with the homologous allergens, but also the IgE antibodies reactive with house dust allergens, the authors have absorbed 10 sera of house dust allergic patients with solid phase mite or epithelia. The absorption procedure removed a large part of the IgE antibodies reactive with specific immunosorbent (Dermatophagoides pteronyssinus or cat epithelia) and in the same way the IgE antibodies reactive with house dust immunosorbent. The percentage of RAST inhibition varied from 65% to 92% for Dermatophagoides pteronyssinus and from 65% to 94% for house dust in patients allergic to house dust and mite; the percentage of RAST inhibition varied from 67% to 92% for cat epithelia and from 73% to 90% for house dust in patients allergic to house dust and cat epithelia. This is in accordance with the hypothesis that house dust is not an allergen per se, but rather a complex mosaic of several allergens including mite, animal epithelia, etc.
Minerva's teeth
Authors: D. Strahan, M. Harris
Journal: BMJ (1981)

<h3>Abstract</h3> Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity of oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes is likely influenced by many aspects of the lesion environment including inflammatory signaling and extracellular matrix (ECM) deposition. These features of MS lesions are typically attributed to infiltrating leukocytes and reactive astrocytes. Here we demonstrate that fibroblasts also contribute to the inhibitory environment in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). Using Col1α1<sup>GFP</sup> transgenic mice, we show that perivascular fibroblasts are activated in the spinal cord at EAE onset, and infiltrate the parenchyma by the peak of behavioral deficits where they are closely associated with areas of demyelination, myeloid cell accumulation, and ECM deposition. We further show that both fibroblast conditioned media and fibroblast ECM inhibit the differentiation of OPCs into mature oligodendrocytes. Taken together, our results indicate that the fibrotic scar is a major component of EAE pathology that leads to an inhibitory environment for remyelination, thus raising the possibility that anti-fibrotic mechanisms may serve as novel therapeutic targets for MS.
Call for worldwide withdrawal of tiotropium Respimat mist inhaler
Authors: R. Beasley, S. Singh, Y. K. Loke, P. Enright, C. D. Furberg
Journal: BMJ (2012)

Tiotropium Respimat mist inhaler increases the risk of death

Ten years ago serious concerns were raised about a link between inhaled anticholinergics and an increased risk of serious cardiovascular events and death in chronic obstructive pulmonary disease (COPD).1 Since then our understanding has grown about the effects of individual formulations of anticholinergic drugs and about their effects in patients with COPD and comorbidities. We believe that evidence of increased mortality from cardiovascular disease and all cause mortality with the tiotropium Respimat mist inhaler is now so strong that this inhaler should be withdrawn from the market.

In 2002, a randomised placebo controlled trial showed that regular use of ipratropium by metered dose inhaler increased the risk of death from cardiovascular disease (relative risk 2.57, 95% confidence interval 1.12 to 6.62).1 In 2008, a systematic review and meta-analysis of 17 randomised controlled trials of ipratropium and tiotropium (13 645 patients) reported an increased risk of the primary composite endpoint of cardiovascular death, myocardial infarction, or stroke (1.60, 1.22 to 2.10).2 It also reported increased risks of myocardial infarction (1.52, 1.04 to 2.22) and cardiovascular death (1.92, 1.23 to 3.00) but not stroke (1.46, …
Phenotypic heterogeneity of erythroblasts in erythroblastic leukemia revealed by monoclonal antibodies
Authors: Amar Das Gupta, Subodh R. Dhond
Journal: American Journal of Hematology (1988)

Eight cases each of erythroleukemia (AML-M6) and erythroblastic crisis of chronic granulocytic leukemia (CGLBC-E) were immunophenotyped with the help of a panel of lineage-associated monoclonal antibodies (McAbs). The latter included those reactive with erythroid progenitor (BFU-E and CFU-E) and erythroid precursors at different stages of maturation. In six of eight cases of AML-M6, erythroblasts revealed an immature phenotype, as evident from reactivity of the blast cells with McAbs directed against the earlier stages of erythroid maturation. One case had the phenotype of CFU-E, and in the remaining case of AML-M6 the erythroblasts showed a "mature" surface antigenic profile. This immunophenotypic spectrum was unrelated to the morphologic maturity of the erythroblasts. In two cases of CGLBC-E, an early erythroblastic phenotype was observed, while in as many cases a "mature" phenotype was present. Four of eight cases, however, revealed a mixed, erythroid plus myeloid phenotype. In one of the four cases, two separate blast populations, which represented erythroblasts and myeloblasts, could be identified. In the remaining three cases the blasts were morphologically homogeneous and undifferentiated. High incidence of HLA-DR positivity in the latter three cases suggests the primitive nature of blasts cells and their closeness to the putative "bipotent" myeloid stem cell. Our study has shown phenotypic heterogeneity of blast cells in AML-M6 and CGLBC-E.
Life in Death
Authors: Abraham Verghese
Journal: Annals of Internal Medicine (1991)

Ad Libitum1 May 1991Life in DeathAbraham Verghese, MDAbraham Verghese, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-9-833 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI notice him in the midst of the bedlam in the room. He is standing at the foot of the bed. His black eyes—heavy lidded, with long eyelashes like those of a woman—blink slowly in the brown face, taking it all in: the jostling, the breathing of people who have run up stairs and down hallways, the many sets of hands crossing and interweaving over the bed, the needle caps and guide wires strewn on the floor, the EKG paper spewing out of the machine, forming a mound on the radiator, the raised voices—"Atropine!" "Epi! NO, NO, Epi!" "Is it... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Abraham Verghese, MDAffiliations: Iowa City, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1991Volume 114, Issue 9 Page: 833-833 Keywords Atropine Breathing ePublished: 1 December 2008 Issue Published: 1 May 1991 PDF downloadLoading ...
Clopidogrel Efficacy and Cigarette Smoking Status
Authors: Paul A. Gurbel, Thomas D. Nolin, Udaya S. Tantry
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Vernier Caliper for Interpreting Electrocardiograms
Authors: Harold R. Wainerdi, James Stewart
Journal: New England Journal of Medicine (1950)

THE measurements required in the interpretation of electrocardiograms are frequently made with relative inexactness. Considerable time may be wasted until a complex or other feature is found that falls on a line from which it may be measured with some accuracy. Experienced cardiologists learn to estimate distances with a high degree of accuracy, but even they may be encumbered with such tools as magnifying lenses and rules and often with drafting calipers. Those who are less experienced frequently need to make certain computations, which, although not elaborate, introduce the possibility of error.The illustrated device (Fig. 1) adapts, for electrocardiographic . . .
SUBCLINICAL ELEVATION OF HIGH SENSITIVE TROPONIN T LEVELS AT THE CONVALESCENT STAGE IS PREDICTIVE FOR 5-YEAR MORTALITY AFTER ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shinsuke Nanto, Masatsugu Hori, Issei Komuro
Journal: Journal of the American College of Cardiology (2014)
Abdominal distension in a 4 year old
Authors: D. Kesavelu, M. Dalzell, V. Eaton
Journal: BMJ (2011)

A 4 year old girl was referred to the paediatric department with a six month history of abdominal distension, irritable mood, reduced appetite, and weight loss.She had recently had loose stools four to five times a day without any associated blood or mucus and "crampy" type abdominal pains after eating foods such as bread and oats.This led her mother to suspect a "food allergy," and avoidance of these foods improved her symptoms.She had no other medical problems.Her birth and developmental histories were normal, and there was no family history of medical problems.On examination she had a distended abdomen, which was soft on palpation and tympanic to percussion.There was no organomegaly, ascites, or lymphadenopathy.She had no peripheral signs of gastrointestinal disease, and all other examinations were unremarkable.Her height and weight were plotted on the 25th centile, and there were no previous measurements with which to compare.Blood investigations showed haemoglobin at 78 g/L (reference range 120-160), total white blood cell count 9.7×10 9 /L (4-11), neutrophils 4.6×10 9 /L (2-7.5), and platelets 211×10 9 /L (150-500).Her blood film was normal, and C reactive protein concentration was 5 mg/L (<5).Liver enzymes and bilirubin were within normal limits, and her albumin was 350 g/L (300-400).Her globulin and immunoglobulin concentrations were normal, but antibodies to tissue transglutaminase were raised at 150 U/ml (0-7 U/ml).Abdominal ultrasound scan was unremarkable. Questions1 What are the differential diagnoses? 2 What is the most likely diagnosis?3 How would you confirm diagnosis?4 How would you manage this condition, and what is the long term prognosis?
Hypoxia and lung mast cells: influence of disodium cromoglycate.
Authors: I P Mungall
Journal: Thorax (1976)

Rats kept in 10% O2 for three or more weeks developed mast cell hyperplasia in the lungs, especially round the alveoli and the small peripheral blood vessels, which became thickened during chronic hypoxia. There was a significant correlation between the degree of right ventricular hypertrophy (RVH) and the numbers of alveolar and small vessel mast cells. However, mast cell hyperplasia developed more slowly than RVH. Daily treatment with disodium cromoglycate failed to prevent RVH in hypoxic conditions but was associated with retardation of growth in both hypoxic and control rats. Neither acute nor chronic hypoxia increased the degree of degranulation in the lung mast cells.
Effect of body mass in children with hematologic malignancies undergoing allogeneic bone marrow transplantation
Authors: Richard Aplenc, Mei-Jie Zhang, Lillian Sung, Xiaochun Zhu, Vincent T. Ho, Kenneth Cooke, Christopher Dvorak, Gregory Hale, Luis M. Isola, Hillard M. Lazarus, Philip L. McCarthy, Richard Olsson, Michael Pulsipher, Marcelo C. Pasquini, Nancy Bunin
Journal: Blood (2014)
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Authors: Leping Cheng, Akiko Arata, Rumiko Mizuguchi, Ying Qian, Asanka Karunaratne, Paul A Gray, Satoru Arata, Senji Shirasawa, Maxime Bouchard, Ping Luo, Chih-Li Chen, Meinrad Busslinger, Martyn Goulding, Hiroshi Onimaru, Qiufu Ma
Journal: Nature Neuroscience (2004)
Ligand-Independent Toll-like Receptor Signals Generated by Ectopic Overexpression of MyD88 Generate Local and Systemic Antitumor Immunity
Authors: Zachary C. Hartman, Takuya Osada, Oliver Glass, Xiao Y. Yang, Gang-jun Lei, H. Kim Lyerly, Timothy M. Clay
Journal: Cancer Research (2010)

Abstract Although critical for initiating and regulating immune responses, the therapeutic use of individual cytokines as anticancer immunotherapeutic agents has achieved only modest clinical success. Consequently, many current strategies have focused on the use of specific immunotherapeutic agonists that engage individual receptors of innate immune networks, such as the Toll-like receptor (TLR) system, each resulting in specific patterns of gene expression, cytokine production, and inflammatory outcome. However, these immunotherapeutics are constrained by variable cellular TLR expression and responsiveness to particular TLR agonists, as well as the specific cellular context of different tumors. We hypothesized that overexpression of MyD88, a pivotal regulator of multiple TLR signaling pathways, could circumvent these constraints and mimic coordinated TLR signaling across all cell types in a ligand-independent fashion. To explore this hypothesis, we generated an adenoviral vector expressing MyD88 and show that Ad-MyD88 infection elicits extensive Th1-specific transcriptional and secreted cytokine signatures in all murine and human cell types tested in vitro and in vivo. Importantly, in vivo intratumoral injection of Ad-MyD88 into established tumor masses enhanced adaptive immune responses and inhibited local tumor immunosuppression, resulting in significantly inhibited local and systemic growth of multiple tumor types. Finally, Ad-MyD88 infection of primary human dendritic cells, tumor-associated fibroblasts, and colorectal carcinoma cells elicited significant Th1-type cytokine responses, resulting in enhanced tumor cell lysis and expansion of human tumor antigen–specific T cells. Thus, Ad-MyD88 initiated robust antitumor activity in established murine tumor microenvironments and in human contexts, suggesting its potential effectiveness as a clinical immunotherapeutic strategy. Cancer Res; 70(18); 7209–20. ©2010 AACR.
Are routine superficial cultures worth while in neonatal practice?
Authors: G P Fox, T A Clarke, T G Matthews
Journal: BMJ (1988)

This was confirmed when he was no longer exposed to the chemical and his symptoms improved.People susceptible to malignant hyperthermia can lead a normal life provided that they take certain precautions, which include avoiding inappropriate anaesthetic agents and neuroleptic drugs and not taking severe exercise in hot conditions.Avoiding occupational exposure to halogenated hydrocarbons such as bromochlorodifluoromethane should be added to the list as these may cause rhabdomyolysis.