tbuckley/cabot-search huggingface dataset:
All Souls' Day
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2011)

Ad Libitum18 January 2011All Souls' DayJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom Setauket, NY 11733.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-2-201101180-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail So much depends on this frail old manwho lurches from his seat—I'm next!—and works his cane across the room.He purses his lips, like a clarinetistleading a parade among the graveson All Souls' Day. So much dependson the white elastic rim of shortsthat shows above his belt, on the caphe swoops above his speckled head,Hey, doc! I'm almost there! WhetherI pick up my instrument and dancebehind him, or spread my picnicon a white sarcophagus, or justcarry my dead inside, so muchdepends on this frail old manthe ... Author, Article, and Disclosure InformationAffiliations: From Setauket, NY 11733.Current Author Address: Jack Coulehan, MD, MPH, 4 Townsend Court, Setauket, NY 11733. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 January 2011Volume 154, Issue 2Page: 93KeywordsSwallowing ePublished: 18 January 2011 Issue Published: 18 January 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation
Authors: Rihab Nasr, Estelle Chiari, Marwan El-Sabban, Renaud Mahieux, Youmna Kfoury, Maher Abdulhay, Victor Yazbeck, Olivier Hermine, Hugues de Thé, Claudine Pique, Ali Bazarbachi
Journal: Blood (2006)
THE USE OF QUININE IN NORMAL LABOUR
Authors: D. A. Mitchell
Journal: BMJ (1930)

There may, even yet, be purists or idealists who will quarrel with the title of this paper. I have a keen recol lection of entering a vicarage at 6 p.m. one day, persuad ing the hostess of a tea party to retire (most reluctantly) to an upper room, and being able to congratulate her on the birth of her eldest daughter while yet the vicar was speeding the parting guests at 6.20 p.m. This is the ideal of midwifery at which we should aim ; but, unfortunately, it is very rarely realized, and there are few of us who would not, if we could, fortify the parturient woman against the possible dangers of her labour. About five years ago I brought before the Clinical Society of Bath a method of pre-natal quininization which owed its origin to Dr. Philip Jones of Coleford. At that time, our claims for the method were very modest. They were, roughly, that labour was considerably hastened ; that it was rendered easier; and that the general well-being of the patients was improved. Since that time a large number of cases have been given this routine, and some thing over 400 of them have been under the direct observa tion of Dr. Jones and myself. In all, the method has been on trial for seven years, and, so far from modifying the claims of five years ago, further experience has made it necessary to add to them. This progress has led me to a careful study of quinine? the drug?and has brought to my notice the experiences of various workers who have studied the action of quinine in every stage of pregnancy. Such a study would tend to make one very critical of any claim made for this routine; but, rather to my own surprise, this study of the drug ?in my own case?appeared to intensify the logic of such conclusions as have been brought forward. I propose, therefore, to mention a few of the more important points noted in the study of quinine in pregnancy, as opposed to labour.
Activation of the Hemostatic Mechanism After Pharmacological Cardioversion of Acute Nonvalvular Atrial Fibrillation
Authors: Luigi Oltrona, Marco Broccolino, Piera A. Merlini, Alessandra Spinola, Antonio Pezzano, Pier M. Mannucci
Journal: Circulation (1997)

Given that the restoration of sinus rhythm after chronic atrial fibrillation is associated with embolic events, anticoagulation is prescribed before and after pharmacological and electrical cardioversion. However, the need for anticoagulation in patients with acute atrial fibrillation (lasting <48 hours) who undergo cardioversion is less clear. In addition, it is not known whether cardioversion to sinus rhythm determines a hypercoagulable state in these patients.In 21 patients with acute nonvalvular atrial fibrillation, plasma median concentrations of thrombin-antithrombin complex, a marker of thrombin generation, significantly increased from 2.8 ng/mL (interquartile range, 2.1 to 4.0 ng/mL) on hospital admission to 3.5 ng/mL (interquartile range, 2.9 to 6.0 ng/mL) after cardioversion to sinus rhythm obtained by means of infusion of antiarrhythmic drugs and decreased to 2.5 ng/mL (interquartile range, 2.0 to 3.5 ng/mL) at the 1-month follow-up visit (P=.04). Similarly, the levels of fibrinopeptide A, a marker of thrombin activity, increased from 1.1 nmol/L (interquartile range, 0.7 to 1.5 nmol/L) at baseline to 1.8 nmol/L (interquartile range, 1.1 to 3.0 nmol/L) after cardioversion and returned to 0.8 nmol/L (interquartile range, 0.6 to 1.1 nmol/L) at the 1-month follow-up visit (P=.02).A significant increase in plasma levels of the markers of thrombin generation and activity was observed in patients with acute atrial fibrillation early after pharmacological cardioversion to sinus rhythm. This is the first biochemical evidence that cardioversion of recent-onset atrial fibrillation determines a hypercoagulable state.
A Rapid Method for Screening Sputums for<i>Histoplasma capsulatum</i>Employing the Fluorescent-Antibody Technic
Authors: Harold J. Lynch, Kathryn L. Plexico
Journal: New England Journal of Medicine (1962)

THE prevalence of mycotic pulmonary disease, especially the chronic form of histoplasmosis that mimics tuberculosis, has led many laboratories to attempt routine isolation of the fungus from the sputum in suspected cases. However, experience indicates that successful mycologic identifications take time and require exacting technic.The direct method of fluorescent-antibody staining has been found to have many useful applications in studies of bacterial and viral diseases. In 1958 Gordon1 used this technic to differentiate species of candida and later2 demonstrated reliable staining of pure cultures of Histoplasma capsulatum. The present study reports on the use of this method as a . . .
Role of complement in xenotransplantation
Authors: T. E. Mollnes, A. E. Fiane
Journal: Allergy (2002)

The xenotransplantation research is driven by the increasing gap between the number of patients with end-stage organ failure on waiting lists for transplantation and the supply of allografts. The lack of success in developing suitable artificial organs for permanent treatment of organ failure has further strengthened the need for xenotransplantation research. Pigs are now generally accepted to be the source animal of choice. Transplantation of pig organs to humans faces several barriers which have to be overcome before it comes to clinical application: (1) anatomical and physiological conditions; (2) immunological rejection mechanisms; (3) molecular compatibility between signal molecules of the two species; (4) risk of transmission of microorganisms, particularly pig endogenous retroviruses; and (5) legal and ethical aspects both with respect to the animal and the recipient. Here we will focus on the role of the complement system in the rejection of immediately vascularized pig-to-primate xenografts. The hyperacute rejection occurring within minutes after transplantation is mediated by binding of natural antibodies to the Galalpha(l-3)Gal epitope on the endothelial cells with subsequent complement activation. Whereas inhibition of complement activation protects against hyperacute rejection, the role of complement in the later rejection phases is less clarified.
A Case of Gout
Authors: W. H. Pearse
Journal: BMJ (1886)

mother, one of whose brothers has had repeated attacks of the dis- eas, and a sister has also had slight gouty symptoms.Two other members of the mother's family have had liver-disee, and one of them glycosmria.CAsE rr.-The last case I have to mention is one that came before me in 1879.Of this, I regret that I have few notes, excepting of the condition of the urine.It is that of a boy, aged 12, who was brought to me on May 12th, 1879, on account of symptoms which led me to examine the urine at once.There was found in it one-twelfth of albumen.He was put to bed on a milk-diet; and, as in Case Ii, by the following day the a]bumen had disappeared.Two days afterwards, a trace was detected.On the 19th, 22nd, 23rd, and 31st, the urine was free from albumen; but, on each occasion, it contained a trace of sugar.On June 4th, there was neither albumen nor sugar.The patient's family, some time afterwards, removed from this neighbourhood.For the purposes of this paper, I. the other day, wrote to the father to inquire whether there was any gout in the family.lie replied that his father, the grandfather of the boy, had been for many years occasionally troubled with gout.We havo here, then, four cases of so-called albuminuria of adoles- cence, in all of which a gouty family history can be traced.The affection, so far as I am aware, seems to have been observed mainly amongst the more cultivated classes, and to be frequently associated with severe mental work, and, perhaps still more, with mental worry, conditions which are well known to be tlho frequent precursors, in older people, of undoubted attacks of gout.It is stated, in a leading article in the Lcancet, I know not on what authority, that Sir Andrew Clark hlas ascertained that 10 per cent. of the young men competing for places in the Indian Civil Service become subjects of albumin- uria."
Implantation of an esophageal squamous cell carcinoma at the site of a percutaneous endoscopic gastrostomy
Authors: K. Volkmer, T. Meyer, M. Sailer, M. Fein
Journal: Endoscopy (2007)

A 54-year-old man presented with a stenosing, moderately differentiated squamous cell carcinoma (SCC) of the proximal esophagus. Tumor stage was cT3-4N1M0. The patient underwent radiochemotherapy with curative intent. A percutaneous endoscopic gastrostomy (PEG) was placed using the standard pull-through method.
Rupture of spleen at colonoscopy.
Authors: W R Ellis, J M Harrison, R S Williams
Journal: BMJ (1979)

proportionating system was dismantled and a gas leak found in the Cambridge Bourdon tube type dialysate temperature gauge which caused the needle pointer to register about 20'C too low.The fault had come on over a period of time and, unfortunately, it had been assumed that the Cambridge gauge was indicating the true dialysate temperature.Therefore the back-up temperature alarm system and the dialysate heater were adjusted to maintain the Cambridge gauge recording in the range 35-41°C.Probably, however, the dialysate was much hotter (possibly as much as 58°C).with topical corticosteroid treatment only and the baby was discharged home after 21 days.AFP concentrations in the bullous fluid and neonatal serum were 6-0 and 5-6 mg/l respectively, indicating transudation of serum.
Expired nitric oxide and airway reactivity in infants at risk for asthma
Authors: Robert S. Tepper, Conrado J. Llapur, Marcus H. Jones, Christina Tiller, Cathy Coates, Risa Kimmel, Jeffrey Kisling, Barry Katz, Yan Ding, Nancy Swigonski
Journal: Journal of Allergy and Clinical Immunology (2008)
Using biological monitoring to assess human exposure to priority toxicants.
Authors: J L Pirkle, E J Sampson, L L Needham, D G Patterson, D L Ashley
Journal: Environmental Health Perspectives (1995)

Scientifically valid exposure assessment is crucial to risk assessment, risk management, and prevention of environmental disease. Scientists have used three tools to assess exposure: exposure history/questionnaire, environmental monitoring (including personal monitoring), and biological monitoring. Combinations of these tools usually provide the exposure information needed to meet objectives of human studies evaluating the exposure-health effect relationship. Biological monitoring is a capable exposure assessment tool that has provided important information used in public health decisions. We briefly describe how risk assessment and risk management decisions for lead, dioxin, and volatile organic compounds have substantially benefited from exposure information obtained from biological monitoring.
Rewarding Women in Academic Medicine
Authors: Phyllis L. Carr
Journal: Annals of Internal Medicine (1994)

Letters15 April 1994Rewarding Women in Academic MedicinePhyllis L. Carr, MD, Lewis E. Kazis, ScD, and Mark A. Moskowitz, MDPhyllis L. Carr, MDMassachesetts General Hospital; Boston, MA 02114Boston University School of Medicine; Boston, MA 02118Search for more papers by this author, Lewis E. Kazis, ScDMassachesetts General Hospital; Boston, MA 02114Boston University School of Medicine; Boston, MA 02118Search for more papers by this author, and Mark A. Moskowitz, MDMassachesetts General Hospital; Boston, MA 02114Boston University School of Medicine; Boston, MA 02118Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-8-199404150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We share Dr. Weisse's concern that seniority is a critical factor in any study comparing the rewards of men and women in academic medicine. For this reason, year of graduation from medical school was evaluated as a continuous variable, as a step function with 5-year intervals, and as a variable dichotomized at the median. The results were the same with each method. We adjusted for year of graduation from medical school as an independent variable in all the multivariable models for outcome, including rank and compensation. Differences persisted despite appropriate adjustment for this critical factor. Likewise, we also ... Author, Article, and Disclosure InformationAffiliations: Massachesetts General Hospital; Boston, MA 02114Boston University School of Medicine; Boston, MA 02118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1994Volume 120, Issue 8Page: 697-698KeywordsAcademic medicineFellowships ePublished: 15 August 2000 Issue Published: 15 April 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A LARGE TERATOMA CONTAINING RUDIMENTARY ARM BONES AND A HAND
Authors: R. J. Brines
Journal: JAMA (1934)

A man, aged 24, a farmer, came to the outpatient clinic in August 1932 for the treatment of a large tumor on the left buttock, which had increased in size gradually since birth. The man was well developed and healthy. When surgical removal was advised he became frightened and returned home. After some correspondence he was encouraged to return, and, March 2, 1933, the tumor was removed without any surgical difficulties being encountered. Large reflected skin flaps were sewed over the denuded area to which the tumor had been attached. Convalescence was uneventful. The tumor weighed 31 pounds (14.1 Kg.) and was firmly attached at one side to the coccyx by dense fibrous tissue. The remainder of the anterior side was loosely attached to the gluteal region. Bones could be felt along the entire posterior medial side of the tumor. A ball-like mass protruded from the upper lateral side. This
Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients
Authors: Y-L. Choi, J-A. Kim, K-T. Jang, D-S. Kim, W-S. Kim, J-H. Lee, J-M. Yang, E-S. Lee, D-Y. Lee
Journal: British Journal of Dermatology (2006)

Although cytomegalovirus (CMV) disease is a severe complication among immunocompromised patients, its cutaneous features have not been frequently reported. As herpes simple virus (HSV) infection commonly develops in CMV skin lesions, a study is needed on the pathogenetic role of CMV in cutaneous lesion formation.The purpose of this study is to characterize the clinical and histopathological features of cutaneous CMV infection and to determine whether CMV plays a true pathogenetic role in cutaneous lesions, or if it is just an innocent bystander during HSV infection among non-AIDS (acquired immune deficiency syndrome), immunocompromised patients.A total of nine human immunodeficiency virus-negative patients diagnosed with cutaneous CMV infection from July 1999 to February 2005 at Samsung Medical Center were analysed in terms of their clinical and histopathological characteristics. In addition, we examined for the co-presence of HSV by performing immunohistochemical analysis and polymerase chain reaction.All the patients were immunocompromised; five had haematological diseases and four were organ transplant recipients. The clinical and histopathological features were similar to those of previous studies of patients with AIDS. Multiple anogenital ulcerations were the most frequent cutaneous presentation (66.7%). Most cytopathic changes were found in the dermis, particularly within the vascular endothelial cells (77.8%) and macrophages (66.7%). However, the association of CMV with concurrent HSV infection was even lower than that seen in patients with AIDS. Only one patient revealed a co-existing cutaneous HSV infection.In non-AIDS individuals, the cutaneous lesions from CMV infection showed similar clinical and histopathological features to those of patients with AIDS. However, skin lesions may not be highly associated with HSV, and CMV does seem to contribute to lesion development as a cutaneous manifestation among the CMV infected, non-AIDS, immunocompromised patients.
Abstract LB-219: Synthetic lethal screening reveals FGFR as one of combinatorial targets to overcome resistance to Met-targeted therapy
Authors: Bogyou Kim
Journal: Cancer Research (2014)

Abstract Met is a receptor tyrosine kinase that promotes cancer progression. In addition, Met has been implicated in resistance of tumors to various targeted therapies such as EGFR inhibitors in lung cancers, and has been prioritized as a key molecular target for cancer therapy. However, the underlying mechanism of resistance to Met targeting drugs is poorly understood. Here, we describe screening of 1310 genes to search for key regulators related to drug resistance to an anti-Met therapeutic antibody (SAIT301) by employing a siRNA-based synthetic lethal screening method. We found that knockdown of 69 genes in Met-amplified MKN45 cells sensitized the anti-tumor activity of SAIT301. Pathway analysis of these 69 genes implicated FGFR as a key regulator for anti-proliferative effects of Met targeting drugs. Inhibition of FGFR3 increased target cell apoptosis through the suppression of Bcl-xL expression, followed by reduced cancer cell growth in the presence of Met targeting drugs. Treatment of cells with the FGFR inhibitors substantially restored the efficacy of SAIT301 in SAIT301-resistant cells and enhanced the efficacy in SAIT301-sensitive cells. In addition to FGFR3, integrin β3 is another potential target for combination treatment with SAIT301. Suppression of integrin β3 decreased AKT phosphorylation in SAIT301-resistant cells and restores SAIT301 responsiveness in HCC1954 cells, which are resistant to SAIT301. Gene expression analysis from using CCLE DB shows cancer cells with high levels of FGFR and integrin β3 are resistant to crizotinib treatment, suggesting FGFR and integrin β3 could be used as predictive markers for Met targeted therapy and provide a potential therapeutic option to overcome acquired and innate resistance for the Met targeting drugs. Citation Format: Bogyou Kim. Synthetic lethal screening reveals FGFR as one of combinatorial targets to overcome resistance to Met-targeted therapy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-219. doi:10.1158/1538-7445.AM2014-LB-219
Thrombosis of the Deep Leg Veins Due to Prolonged Sitting
Authors: John Homans
Journal: New England Journal of Medicine (1954)

"SPONTANEOUS" thrombosis, according to DeCamp, Landry, Ochsner and DeBakey,1 represents between 4 and 5 per cent of all venous thrombosis in the limbs (the lower limbs almost exclusively). The very word indicates that the conditions under which the disease occurs in ambulatory persons have not been recognized. How sudden muscular efforts and strains may cause thrombosis in the deep lower-leg veins of even young and active men has been pointed out by Crane,2 but such an influence is as often absent as present. Perhaps Naide's3 account of thrombosis in tall men gives a better hint of the nature of the . . .
Repeated prolonged whole-body low-intensity exercise: effects on insulin sensitivity and limb muscle adaptations
Authors: Joern W. Helge, Kristian Overgaard, Rasmus Damsgaard, Karsten Sørensen, Jesper L. Andersen, Stig E.U. Dyrskog, Kjeld Hermansen, Bengt Saltin, Jørgen F.P. Wojtaszewski
Journal: Metabolism (2006)
Echocardiography in Wolff-Parkinson-White syndrome.
Authors: M S Chandra, R E Kerber, D D Brown, D C Funk
Journal: Circulation (1976)

Twenty-six patients with Wolff-Parkinson-White (WPW) syndrome were studied by echocardiography. They were classified into the following WPW types: anterior right ventricular pre-excitation (Type I) - six patients; posterior right ventricular pre-excitation (Type II) - six patients; posterior left ventricular pre-excitation (Type III) - fourteen patients. Twenty-three patients were in WPW at the time of study. Four patients with Type I WPW had abnormal systolic motion of the interventricular septum: three paradoxical and one flat. Patients with Type II and Type III WPW had no septal motion abnormalities related to pre-excitation. Three patients had intermittent WPW, Type III; in all three only minor changes in normal septal motion were apparent on WPW beats. Associated cardiac abnormalities were evident in six patients: two mitral prolapse (one Type II WPS and one Tpe III); one idiopathic hypertrophic subaortic stenosis (Type III); one congestive cardiomyopathy (Type III); one hypertrophic nonobstructive cardiomyopathy (Type I); and one atrial septal defect (Type II). We conclude that abnormal interventricular septal motion may occur with Type I WPW abnormality. Other abnormalities are detectable by echocardiography in a high proportion of WPW patients, but do not appear to be associated with any single Wolff-Parkinson-White type.