Effects of Testosterone Replacement on Response to Sildenafil Citrate
Authors: Allen D. Seftel, Geoffrey Hackett
Journal: Annals of Internal Medicine (2013)

Letters2 April 2013Effects of Testosterone Replacement on Response to Sildenafil CitrateAllen D. Seftel, MD and Geoffrey Hackett, MDAllen D. Seftel, MDFrom Cooper Medical School of Rowan University, Cooper University Hospital, Camden, New Jersey, and Good Hope Hospital, Birmingham, United Kingdom.Search for more papers by this author and Geoffrey Hackett, MDFrom Cooper Medical School of Rowan University, Cooper University Hospital, Camden, New Jersey, and Good Hope Hospital, Birmingham, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-7-201304020-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Spitzer and colleagues' article (1) purports to show that, in men with erectile dysfunction (ED), adding testosterone replacement therapy to a successful course of phosphodiesterase type 5 (PDE5) inhibitor therapy (oral sildenafil) to further augment erectile function was not beneficial. The International Index of Erectile Function's (IIEF's) erectile function domain (EFD) was used to assess baseline and posttreatment erectile function, with a mean baseline EFD score of 12.2 for the testosterone group and 12.0 for the placebo group. A score of 12.0 places these men in the “moderate” ED category (2).Sildenafil administration alone was associated with ...References1. Spitzer M, Basaria S, Travison TG, Davda MN, Paley A, Cohen B, et al. Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: a parallel, randomized trial. Ann Intern Med. 2012;157:681-91. [PMID: 23165659] LinkGoogle Scholar2. Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology. 1999;54:346-51. [PMID: 10443736] CrossrefMedlineGoogle Scholar3. Rosen RC, Allen KR, Ni X, Araujo AB. Minimal clinically important differences in the erectile function domain of the International Index of Erectile Function scale. Eur Urol. 2011;60:1010-6. [PMID: 21855209] CrossrefMedlineGoogle Scholar4. Buvat J, Hatzichristou D, Maggi M, Farmer I, Martínez-Jabaloyas JM, Miller PJ, et al. Efficacy, tolerability and satisfaction with sildenafil citrate 100-mg titration compared with continued 50-mg dose treatment in men with erectile dysfunction. BJU Int. 2008;102:1645-50. [PMID: 18710446] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Allen D. Seftel, MD; Geoffrey Hackett, MDAffiliations: From Cooper Medical School of Rowan University, Cooper University Hospital, Camden, New Jersey, and Good Hope Hospital, Birmingham, United Kingdom.Disclosures: Dr. Seftel: Board membership: Journal of Urology; Consultancy: Lilly, Endo, Auxilium, Abbott, Actient. Dr. Hackett: Payment for lectures including service on speakers bureaus: Pfizer, Lilly. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Testosterone Replacement on Response to Sildenafil Citrate in Men With Erectile Dysfunction Matthew Spitzer , Shehzad Basaria , Thomas G. Travison , Maithili N. Davda , Amanda Paley , Beth Cohen , Norman A. Mazer , Philip E. Knapp , Samson Hanka , Kishore M. Lakshman , Jagadish Ulloor , Anqi Zhang , Katie Orwoll , Richard Eder , Lauren Collins , Nurahmed Mohammed , Raymond C. Rosen , Leonard DeRogatis , and Shalender Bhasin Effects of Testosterone Replacement on Response to Sildenafil Citrate Antonio Aversa , Emmanuele A. Jannini , Mario Maggi , and Andrea Lenzi Effects of Testosterone Replacement on Response to Sildenafil Citrate Matthew Spitzer , Shehzad Basaria , Thomas G. Travison , and Shalender Bhasin Effects of Testosterone Replacement on Response to Sildenafil Citrate Steven Smoger Metrics 2 April 2013Volume 158, Issue 7Page: 569KeywordsCohort studiesConflicts of interestErectile dysfunctionPhosphodiesterasesTestosteroneUrology ePublished: 2 April 2013 Issue Published: 2 April 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...