tbuckley/cabot-search huggingface dataset:
Lithium and Leukocytosis
Authors: F. ANTHONY GRECO
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 January 1976Lithium and LeukocytosisF. ANTHONY GRECO, M.D.F. ANTHONY GRECO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-1-102_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their recent paper "Lithium Salts: 1970-1975" (Ann Intern Med83:527-533, 1975), Baldessarini and Lipinski briefly mention the leukocytosis (granulocytosis) that occurs in patients taking lithium. The authors hint that the corresponding temporary increase in circulating adrenocorticosteroids is probably not responsible for the persistent leukocytosis. There is evidence suggesting that lithium induces human granulocyte proliferation (1, 2). Circulating (in vivo) unsaturated vitamin B12binding capacity, an index of total blood granulocyte pool (3), is elevated in patients with granulocytosis who are taking lithium (1). Lithium added to human bone marrow in vitro also increases granulocyte colony formation...References1. TISMANHERBERTROSENBLATT GVS: Evidence that lithium induces human granulocyte proliferation. Elevated serum vitamin B12 binding capacity in vivo and granulocyte colony proliferation in vitro. Br J Haematol 24:767-771, 1973 CrossrefMedlineGoogle Scholar2. GUPTAROBINSONSMYTH RWC: Efficacy of lithium in rheumatoid arthritis with granulocytopenia (Felty's Syndrome). Arthritis Rheum 18:179-184, 1975 CrossrefMedlineGoogle Scholar3. CHIKKAPPACORCINOGREENBERG GLM: Correlation between various blood white cell pools and the serum B12-binding capacities. Blood 37:147-151, 1971 CrossrefGoogle Scholar4. TISMAN G: Lithium carbonate protection against drug-induced leukopenia in lymphosarcoma patients. J Int Res Commun (Research on Cancer, Clinical Pharmacology and Therapeutics, Hematology) 2:1509, 1974 Google Scholar5. JACOBHERBERT EV: Lithium therapy for neutropenias (abstract). Clin Invest 53:35-36, 1974 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIncrease of Natural Killer Activity of Mouse Lymphocytes Following in vitro and in Vivo Treatment with LithiumLithium Modulates Mitogen Induced Natural Killer Activlty and Interferon ProductionThe effect of lithium carbonate on lymphocyte, granulocyte, and platelet functionThe Bactericidal Defect of Neutrophil Function with Lithium Therapy 1 January 1976Volume 84, Issue 1Page: 102-102KeywordsBloodBone marrowGranulocytesLeukocytosisSalts Issue Published: 1 January 1976 PDF downloadLoading ...
Charity Hospital, New Orleans
Authors: Wayne F. Larrabee
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Radiologist as a Consultant
Authors: William P. Shuman, Richard S. Heilman
Journal: JAMA (1979)

IN TRADITIONAL clinical-radiologic interactions, the radiologic workup of diagnostic problems is orchestrated by the clinical service. This relationship works satisfactorily in the evaluation of straightforward clinical problems, but commonly breaks down if the workup is complex. This is true in large measure because few areas of medicine have shown greater recent change than has diagnostic radiology. Radiologic techniques unheard of ten years ago, such as computerized axial tomography, ultrasonography, percutaneous biopsy technique, and subselective angiography, are now generally available and regarded as nearly indispensable tools. In addition to remarkable advances in imaging techniques, radiology now offers startling interventionist services such as percutaneous internal biliary drainage, selective embolization procedures, and transcutaneous intraarterial dilation. Even if a referring physician were to make extraordinary effort to review the contemporary radiologic literature pertinent to his specialty, he would still be relatively unfamiliar with the particulars of the radiologic equipment, skills, and biases available to
The Spleen: Structure, Function and Clinical Significance
Authors: T. Michael White
Journal: JAMA (1991)

Prior to initiating a review of<i>The Spleen</i>I suspected that I would find little to aid my clinical practice that would not be readily available within a few moments by interfacing with a computerized medical literature search such as Grateful Med. I was wrong. This monograph is an intriguing, useful text that deserves attention as an efficient starting point for the scientist, internist, or surgeon pursuing an enigma involving the spleen. The text itself is exceptionally handsome and well indexed. It includes helpful schematic drawings and electron micrographs. Useful tables and figures are plentiful. Data presented are meticulously referenced. In the preface editor Anthony J. Bowdler chooses to review for the reader the historical progress of the scientific and clinical communities in relating structure and function to the clinical significance of Galen's "organ of mystery." I found this to be a particularly enjoyable, informative, and effective orientation for the
Toward a Personalized Treatment of Hodgkin's Disease
Authors: Vincent T. DeVita, José Costa
Journal: New England Journal of Medicine (2010)

In this issue of the Journal, Steidl et al.1 provide a technically sound and important model for using molecular tools to better predict how various cancers will respond to currently effective treatments. One example of such cancers is Hodgkin's disease, which has been curable in its early stages with radiotherapy and in its advanced stages with combination chemotherapy for almost 40 years. However, until recently, Hodgkin's disease has trailed behind other cancers in the application of molecular analysis because of the rarity of the malignant Reed–Sternberg cell in the lesion and the complex composition of the tumor tissue. Despite . . .
Smoke Screen: Women's Smoking And Social Control
Authors: N. Britten
Journal: BMJ (1996)

Lorraine Greaves Scarlet Press, £9.99, pp 144 ISBN 1 85727 058 4

Smoking is an emotive issue. Some doctors refuse to treat patients who smoke, while others simply don't understand why people continue to smoke. The value of this book is that it helps non-smokers understand the meaning of smoking.

Young women now have higher smoking rates than young men in several countries. In the feminist tradition of Hilary Graham and Bobbie Jacobsen, Greaves has conducted qualitative research into Canadian and Australian women's feelings …
Impassive Support for The Active Voice
Authors: Rosamond Bettencourt
Journal: JAMA (1973)

To the Editor.—  The virtual ban on the passive  is not all that virtual; most experienced medical writers agree that a smooth blending of active and passive voice is often a hallmark of that rare entity, the exquisitely written medical paper—the breed is not quite yet extinct. As an ex-newspaper woman, I protest that newspaper writing and medical papers are so at variance that it is grammar-schoolish to remind us that in the former type of writing, Man bites dog has more bite (a sorry pun) than Dog bitten by man. May I refer you to your unfortunately discontinued series on medical writing, from which I have derived benefit? One of these articles was entitled Monotony and dealt with overuse (not ban) of the passive voice. True, case-report kinds of medical articles leave little leeway for activity of the voice; however, I have managed to liven some case reports
Coupling of Hemodynamic Measurements With Oxygen Consumption During Exercise Does Not Improve Risk Stratification in Patients With Heart Failure
Authors: Donna Mancini, Stuart Katz, Lisa Donchez, Keith Aaronson
Journal: Circulation (1996)

Background Measurement of peak V̇ o 2 has become an accepted method to select patients for cardiac transplantation. Some investigators have suggested that the addition of exercise hemodynamic measurements can further enhance risk stratification because these measurements may identify patients with a noncardiac limitation to exercise. Methods and Results Accordingly, we performed maximal bicycle exercise with respiratory gas analysis and hemodynamic measurements in 65 patients (47 men, 18 women) 53±10 years old (mean±SD) who underwent a transplant evaluation at Columbia Presbyterian Medical Center. Skeletal muscle oxygenation of the vastus lateralis during exercise was assessed with near-infrared spectroscopy. Exercise hemodynamic, ventilatory, and muscle oxygenation measurements were obtained in all patients. For each subject, a linear correlation was derived between V̇ o 2 and pulmonary artery saturation (PA Sa o 2 ). The slope of this relationship and a theoretical V̇ o 2max at a PA Sa o 2 of 0% (V̇ o 2 intercept) was derived. Baseline measurements were left ventricular ejection fraction, 22±9%; pulmonary capillary wedge pressure (PCWP), 16±10 mm Hg; cardiac index (CI), 2.1±0.5 L·min −1 ·m −2 ; and PA Sa o 2 , 53±8%. The cardiac output response to exercise was categorized as normal or abnormal by comparison to the linear equation of peak V̇ o 2 versus peak cardiac output as described by Higginbotham. Exercise measurements were peak V̇ o 2 , 12.1±3.0 mL·kg −1 ·min −1 ; V̇ o 2 intercept, 19.1±5.5 mL·kg −1 ·min −1 ; PCWP, 31±11 mm Hg; CI, 3.8±1.3 L·min −1 ·m −2 ; and PA Sa o 2 , 27±9%. Only 6% of patients exhibited a normal cardiac output response to exercise. Multivariate analysis was performed with peak V̇ o 2 , V̇ o 2 intercept, skeletal muscle oxygenation at end exercise, and peak exercise hemodynamic variables. Only left ventricular stroke work and left ventricular stroke work index were shown to be predictive of survival. Conclusions Addition of exercise hemodynamic measurements to noninvasive metabolic stress testing minimally improves risk prognostication in patients with severe heart failure.
Dual luciferase labelling for non-invasive bioluminescence imaging of mesenchymal stromal cell chondrogenic differentiation in demineralized bone matrix scaffolds
Authors: Marta Vilalta, Christian Jorgensen, Irene R. Dégano, Yuti Chernajovsky, David Gould, Danièle Noël, José A. Andrades, José Becerra, Nuria Rubio, Jerónimo Blanco
Journal: Biomaterials (2009)
STUDIES ON LYMPHOGRANULOMA VENEREUM
Authors: Geoffrey Rake, Helen P. Jones
Journal: The Journal of Experimental Medicine (1942)

Making use of the fact that the cells of the yolk sac of the developing embryo are readily infected with the agent of lymphogranuloma venereum and that the virus bodies can be readily observed in these cells because of the structure of the latter, the development of this agent has been followed at short intervals. It has been found to go through a regular cycle of development similar to that described for psittacosis in the spleen and less fully for lymphogranuloma venereum in the brain of infected mice. The development as observed microscopically can be shown to run parallel to changes in the infective titre of the yolk sac as tested in other eggs.
Familial clustering of polymorphic light eruption in relatives of patients with lupus erythematosus: evidence of a shared pathogenesis
Authors: T.P. Millard, C.M. Lewis, M.A. Khamashta, G.R.V. Hughes, J.L.M. Hawk, J.M. Mcgregor
Journal: British Journal of Dermatology (2001)

Abnormal photosensitivity is a common feature of many forms of lupus erythematosus (LE).To examine the role of polymorphic light eruption (PLE) as a possible predisposing factor for cutaneous forms of LE.Eighty-five patients with well-characterized subacute cutaneous LE (SCLE) and discoid LE (DLE) were recruited from outpatient clinics, and the prevalence of PLE determined by detailed interview and clinical examination.Symptoms consistent with PLE were reported in 61% and 55% of SCLE and DLE patients, respectively; this was significantly higher than the overall population prevalence of 13.6% (P < 0.001), giving a relative risk (RR) for PLE in SCLE patients of 3.37 (95% confidence interval, CI 2.46--4.28) and DLE patients of 3.11 (95% CI 2.31--3.91). PLE developed before the onset of LE in 61% of cases (median interval 12 years, range 1--40), concomitantly in 24%, and subsequently in a further 15% (median interval 3.5 years, range 1--25). To delineate the relationship between PLE and LE further, the prevalence of PLE was determined in 103 otherwise unaffected first-degree relatives of SCLE and DLE probands; we had previously demonstrated clustering of PLE in families, reflecting a strong genetic component. We found a significantly higher PLE prevalence in relatives of the LE probands than in the general population (P < 0.001), giving an RR for PLE of 2.29 (95% CI 1.55--3.03) and 2.61 (95% CI 1.32--3.89) for female and male relatives, respectively.The high prevalence of PLE in LE patients, together with clustering of PLE among first-degree relatives of SCLE and DLE probands, suggests that there may be a shared pathogenetic basis for PLE and cutaneous LE. We propose that predisposition to PLE may contribute to the LE phenotype in otherwise susceptible individuals.
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
Authors: Elsa Suberbielle, Pascal E Sanchez, Alexxai V Kravitz, Xin Wang, Kaitlyn Ho, Kirsten Eilertson, Nino Devidze, Anatol C Kreitzer, Lennart Mucke
Journal: Nature Neuroscience (2013)
Early evidence of scleroderma
Authors: J. Dequeker, L. Vanopdenbosch, A. C. Ojugas
Journal: BMJ (1995)

The painting of Archangel Raphael and Bishop Francisco Domonte by Murillo (1680) is in the Pushkin Museum of Fine Arts in Moscow (fig 1). The portrait of the bishop in the lower right hand corner shows several characteristic features of scleroderma. The most striking alterations of the skin are the numerous small telangiectases on the face, lips, and hands and the tight skin around the nose, cheeks, and forehead (fig2)). At the finger the transverse skin plicae of the knuckles are not visible and the …
President of British Pain Society is forced from office after refusing to denounce NICE guidance on low back pain
Authors: Z. Kmietowicz
Journal: BMJ (2009)

The president of the British Pain Society was forced to resign on 21 July after a campaign from members who were unhappy with guidelines on the management of low back pain from the National Institute for Health and Clinical Excellence (NICE), which he helped develop.

In a letter to the BMJ this week Michael Rawlins, chairman of NICE, and Peter Littlejohns, the institute’s clinical and public health director, called the move to oust Paul Watson as “shameful” and “professional victimisation of the worst kind” ( BMJ 2009:339:b3028, doi:10.1136/bmj.b3028).

Professor Watson, who has been president of the society since April, said he was “very disappointed” about what had …
HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection
Authors: Charles R.M. Bangham, Lucy B. Cook, Anat Melamed
Journal: Seminars in Cancer Biology (2013)

Human T lymphotropic virus type 1 (HTLV-1) causes a range of chronic inflammatory diseases and an aggressive malignancy of T lymphocytes known as adult T-cell leukaemia/lymphoma (ATLL). A cardinal feature of HTLV-1 infection is the presence of expanded clones of HTLV-1-infected T cells, which may persist for decades. A high viral burden (proviral load) is associated with both the inflammatory and malignant diseases caused by HTLV-1, and it has been believed that the oligoclonal expansion of infected cells predisposes to these diseases. However, it is not understood what regulates the clonality of HTLV-1 in vivo, that is, the number and abundance of HTLV-1-infected T cell clones. We review recent advances in the understanding of HTLV-1 infection and disease that have come from high-throughput quantification and analysis of HTLV-1 clonality in natural infection.
Book Review Markers in Cardiology: Current and Future Clinical Applications (American Heart Association Monograph Series.) Edited by Jesse E. Adams III, with Fred S. Apple, Allan S. Jaffe, and Alan H.B. Wu. 272 pp. Armonk, N.Y., Futura, 2001. $79. 0-87993-472-7
Authors: Bertil Lindahl
Journal: New England Journal of Medicine (2001)
A method to quantitate cell numbers of muscle cells and non-muscle cells in homogenised heart cell cultures
Authors: A VAN DER LAARSE, L HOLLAAR, E J M VAN DER VALK, S HAMERS
Journal: Cardiovascular Research (1989)

Journal Article A method to quantitate cell numbers of muscle cells and non-muscle cells in homogenised heart cell cultures Get access A VAN DER LAARSE, A VAN DER LAARSE From the Department of Cardiology, University Hospital, Leiden, The Netherlands Address for correspondence and reprints: A van der Laarse, PhD, Department of Cardiology, Building 1, C5-P24, University Hospital, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands. Search for other works by this author on: Oxford Academic PubMed Google Scholar L HOLLAAR, L HOLLAAR From the Department of Cardiology, University Hospital, Leiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar E J M VAN DER VALK, E J M VAN DER VALK From the Department of Cardiology, University Hospital, Leiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar S HAMERS S HAMERS From the Department of Cardiology, University Hospital, Leiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 11, November 1989, Pages 928–933, https://doi.org/10.1093/cvr/23.11.928 Published: 01 November 1989 Article history Accepted: 15 May 1989 Published: 01 November 1989
THE NATURE OF THE COLICIN K RECEPTOR OF ESCHERICHIA COLI CULLEN
Authors: Hans Ulrich Weltzien, Margeris A. Jesaitis
Journal: The Journal of Experimental Medicine (1971)

Cell walls of E. coli strains B and Cullen contain specific receptors for colicin K and for the T2, T6, and C16 phages. The receptors for the bacteriocin and the T6 virus are located in the outer layers of the cell wall of these microorganisms and are absent in their cytoplasmic membrane. The receptors for colicin K, phage T2, and the T6 and C16 viruses differ in their stability toward enzymes and chemical reagents. Their specificity must therefore be determined by different chemical groupings. The colicin K receptor is inactivated by certain proteolytic enzymes and by reagents which combine with tryptophan. It is concluded therefore that proteins or peptides containing this amino acid are essential for biological activity of the receptor.
The stem cell niche: tissue physiology at a single cell level
Authors: Jonathan Hoggatt, David T. Scadden
Journal: Journal of Clinical Investigation (2012)

Stem cells are the critical unit affecting tissue maintenance, regeneration, and repair, with particular relevance to the tissues with high cell turnover. Stem cell regulation accommodates the conflicting needs of prompt responsiveness to injury and long-term preservation through quiescence. They are, in essence, the fundamental unit by which a tissue handles changing physiologic needs throughout the lifetime of the organism. As such, they are the focal point of dynamic tissue function, and their governance is physiology expressed at a cellular and molecular level. Here, we discuss the multiple components representing the stem cell niche in hematopoiesis and argue for a unbiased mapping of the niche constituents under different conditions as the first step in developing systems physiology.
Unexpectedly High Recanalization Rate in Patients with Pulmonary Embolism Treated with Anticoagulants Alone
Authors: Raffaele Pesavento, Lucia Filippi, Antonio Pagnan, Adriana Visonà, Paolo Pauletto, Giorgio Vescovo, Stefano Cuppini, Giampietro Beltramello, Sabina Villalta, Giorgio De Conti, Valentina Vedovetto, Anna Chiara Frigo, Paolo Prandoni
Journal: American Journal of Respiratory and Critical Care Medicine (2014)
THE INFLATIONARY FORCE PRODUCED BY PULMONARY VASCULAR DISTENTION IN EXCISED LUNGS. THE POSSIBLE RELATION OF THIS FORCE TO THAT NEEDED TO INFLATE THE LUNGS AT BIRTH
Authors: Mary Ellen Avery, N. Robert Frank, Irwin Gribetz
Journal: Journal of Clinical Investigation (1959)

Among the forces that may contribute to the first inflation of the lungs after birth, those de- veloped through changes in the pulmonary circu- latory system have been assigned primary impor- tance by Jaykka (1), Bonham Carter (2) and Adams, Karlberg and Lind (3).Possibly the ear- liest basis for this view was provided during the last century by von Basch (4) who showed in ani- mals and also in experimental models that pulmo- nary vascular congestion, presumably at the capil- lary level, tends to increase the volume of gas in the lungs.Recently, it was demonstrated in ex- cised cats' lungs that the expansile force resulting from vascular congestion is greatest when the lungs are collapsed (5).Together, these findings might be taken as evidence underscoring the role of vas- cular distention in expanding the lungs at birth.Before this view is accepted, however, two facts must be established.One is that the increase in pulmonary blood flow precedes the first breath.This is contrary to the findings of Dawes in fetal lambs that pulmonary blood flow is increased only after inflation has occurred (6).The other is that the force developed through vascular filling or con- gestion is sufficiently large to cause air to enter the lung.The object of this study was to test this sec- ond possibility.Experiments were carried out to compare the distending forces produced by a wide range of pulmonary vascular pressures with the force required to inflate the lungs.Measure- ments were made on excised lungs of adult cats and dogs that were freed of gas to simulate their condition at birth, and on lungs of puppies and newborn infants that had not breathed.