tbuckley/cabot-search huggingface dataset:
Whipple's Disease Presenting as Aortic Insufficiency
Authors: David G. Bostwick, Klaus G. Bensch, Jerome S. Burke, Margaret E. Billingham, D. Craig Miller, Jean C. Smith, David F. Keren
Journal: New England Journal of Medicine (1981)

CONGESTIVE heart failure, pericardial friction rubs, systolic murmurs, nonspecific electrocardiographic changes, and hypotension usually herald cardiac involvement in patients with Whipple's disease and occur after documentation of disease in the small intestine.1 2 3 4 5 6 7 8 9 10 11 12 Cardiac manifestations are associated with collections of periodic acid–Schiff (PAS)-positive macrophages within the pericardium and myocardium,1 2 3 4 5 6 7 8 9 10 , 13 and these cells may also give rise to endocardial and valvular vegetations, usually of the mitral valve.1 , 2 , 6 , 12 Our clinical observation of a middle-aged woman has revealed that Whipple's disease may present as aortic insufficiency before clinically apparent intestinal, articular, or systemic involvement, despite the presence of widespread disease.Case ReportIn January . . .
Lentivirus Mediated HO-1 Gene Transfer Enhances Myogenic Precursor Cell Survival After Autologous Transplantation in Pig
Authors: Thomas Laumonier, Sheng Yang, Stephane Konig, Christine Chauveau, Ignacio Anegon, Pierre Hoffmeyer, Jacques Menetrey
Journal: Molecular Therapy (2007)

Cell therapy for Duchenne muscular dystrophy and other muscle diseases is limited by a massive early cell death following injections. In this study, we explored the potential benefit of heme oxygenase-1 (HO-1) expression in the survival of porcine myogenic precursor cells (MPCs) transplanted in pig skeletal muscle. Increased HO-1 expression was assessed either by transient hyperthermia or by HO-1 lentiviral infection. One day after the thermic shock, we observed a fourfold and a threefold increase in HSP70/72 and HO-1 levels, respectively. This treatment protected 30% of cells from staurosporine-induced apoptosis in vitro. When porcine MPC were heat-shocked prior to grafting, we improved cell survival by threefold at 5 days after autologous transplantation (26.3 +/- 5.5% surviving cells). After HO-1 lentiviral transduction, almost 60% of cells expressed the transgene and kept their myogenic properties to proliferate and fuse in vitro. Apoptosis of HO-1 transduced cells was reduced by 50% in vitro after staurosporine induction. Finally, a fivefold enhancement in cell survival was observed after transplantation of HO-1-group (47.5 +/- 9.1% surviving cells) as compared to the nls-LacZ-group or control group. These results identify HO-1 as a protective gene against early MPC death post-transplantation.
Left atrial pressure-volume relation in humans: A new method based on direct nontransseptal left atrial catheterization and echocardiography
Authors: Costas Stratos, Christodoulos Stefanadis, Asimakis Sideris, Charalambos Vlachopoulos, Anastasios Antoniou, Konstantinos Toutouzas, Spyros Lambrou, Harisios Boudoulas, Pavlos Toutouzas
Journal: Journal of the American College of Cardiology (1996)
Protein May Play Dual Role in Diabetes Pathogenesis
Authors: Tracy Hampton
Journal: JAMA (2013)

A protein known to drive programmed death of pancreatic beta cells in both type 1 and type 2 diabetes also causes these cells to stop making insulin, report researchers from the University of Alabama at Birmingham (Xu G et al. Nat Med. doi:10.1038/nm.3287 [published online August 25, 2013]).
Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia
Authors: N. Torkamani, N.W. Rufaut, L. Jones, R. Sinclair
Journal: British Journal of Dermatology (2014)

Journal Article Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia Get access N. Torkamani, N. Torkamani Department of Dermatology School of Medicine and Dentistry University of Melbourne Carlton Vic. AustraliaDepartment of Dermatology 185‐187 Hoddle Street level one Epworth Health Dermatology Laboratory Richmond Vic. 3121 Australia Search for other works by this author on: Oxford Academic Google Scholar N.W. Rufaut, N.W. Rufaut Department of Dermatology School of Medicine and Dentistry University of Melbourne Carlton Vic. AustraliaDepartment of Dermatology 185‐187 Hoddle Street level one Epworth Health Dermatology Laboratory Richmond Vic. 3121 Australia Search for other works by this author on: Oxford Academic Google Scholar L. Jones, L. Jones Department of Dermatology School of Medicine and Dentistry University of Melbourne Carlton Vic. AustraliaDepartment of Dermatology 185‐187 Hoddle Street level one Epworth Health Dermatology Laboratory Richmond Vic. 3121 Australia Search for other works by this author on: Oxford Academic Google Scholar R. Sinclair R. Sinclair Department of Dermatology School of Medicine and Dentistry University of Melbourne Carlton Vic. AustraliaDepartment of Dermatology 185‐187 Hoddle Street level one Epworth Health Dermatology Laboratory Richmond Vic. 3121 Australia Correspondence Rodney Sinclair. E‐mail: rodney.sinclair@epworthdermatology.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 6, 1 June 2014, Pages 1291–1298, https://doi.org/10.1111/bjd.12921 Published: 01 June 2014
Transplantation Biology and Medicine
Authors: Felix T. Rapaport
Journal: JAMA (1979)

THE RAPID growth of transplantation since its relatively modest beginnings at the biennial conferences of the New York Academy of Sciences almost a quarter of a century ago has extended the duration of the international congresses to a full five days. The number of new ideas and facts presented at these gatherings continues to attest to the vitality of the transplantation community. More than ever this discipline has continued to benefit from the intimate interaction (and not infrequently cross-irritation) of biologists and clinicians for whom the Transplantation Society serves as a unique, common forum. These considerations were never more in evidence than at the recently concluded Seventh International Congress of the Transplantation Society—a broadly interdisciplinary gathering of more than 1,400 contributors representing 38 different nations throughout the world. There is no question that a preponderance of the 455 reviews, special reports, and invited talks presented at this gathering will have
A Plastic Tube for the Maintenance of the Straightening of the Sigmoid Colon during Coloscopy
Authors: P. Deyhle
Journal: Endoscopy (1972)

In order to maintain the straightening of the sigmoid colon during coloscopy a less flexible plastic tube is put over the coloscope after straightening. - The tube has the advantage compared to the method with the flexible steel wire, that the instrument channel is free for suction. It is of great help in putting the coloscope as far as the cecum.
Atrial Mapping and Radiofrequency Catheter Ablation in Patients With Idiopathic Atrial Fibrillation
Authors: Fiorenzo Gaita, Riccardo Riccardi, Leonardo Calò, Marco Scaglione, Lucia Garberoglio, Renzo Antolini, Michele Kirchner, Filippo Lamberti, Elena Richiardi
Journal: Circulation (1998)

Background —Knowledge of the electrophysiological substrates and the cure of atrial fibrillation (AF) is still unsatisfactory. The goal of this study was to evaluate the electrophysiological features of idiopathic AF and their relationship to the results of radiofrequency (RF) catheter ablation of AF and the safety and effectiveness of this procedure. Methods and Results —Sixteen patients with idiopathic AF underwent atrial mapping during AF and then RF ablation in the right atrium. The atrial activation was simultaneously recorded in four regions in the right atrium: high lateral wall (HL), low lateral wall (LL), high septum (HS), and low septum (LS) and in the left atrium through the coronary sinus (CS). In these regions, we evaluated the atrial fibrillation intervals (FF) and the morphological features of AF recordings by Wells’ classification. No complications occurred during RF ablation. Of the 16 patients, 9 (56%) without AF recurrences during the follow-up (11±4 months) were considered successfully ablated. These patients showed a significantly shorter mean FF interval in the HS and the LS (122±32 and 126±28 ms, respectively) than in the HL and LL (159±24 and 156±28 ms, respectively). Moreover, the septum had more irregular electrical activity with greater beat-to-beat changes in FF and a higher prevalence of type III AF than the lateral region. The CS had similar behavior to the septum. Conversely, patients with unsuccessful ablation had an irregular atrial activity in the lateral wall, septum, and CS with no significant differences between the different sites. Conclusions —Right atrial endocardial catheter ablation of AF is a safe procedure and may be effective in some patients with idiopathic AF. The atrial mapping during AF showed a more disorganized right atrial activation in the septum than in the lateral wall in patients with successful ablation.
Low nicotine and nicotine-free cigarettes no less harmful to smokers, research finds
Authors: Roger Dobson
Journal: BMJ (2008)

Perceptions that low nicotine and nicotine-free cigarettes are less harmful than conventional cigarettes are not supported by research.

Smokers might have reduced exposure to some toxicants, but exposure to others is greater, say researchers in Toxicology (2008 May 24 doi: 10.1016/j.tox.2008.05.009).

“This situation would likely be exacerbated by the users compensating for the lower nicotine yield and inhaling more, thereby further altering the smoke chemistry,” say the authors, whose tests showed that condensates of smoke from the nicotine-free and low nicotine cigarettes had …
Identification of Nursing Homes Needs
Authors: Frederick C. Swartz
Journal: JAMA (1966)

The nursing home in the United States has changed, is changing. The changes have not been uniform. In general, there seems to be more of the early type house on the Atlantic seaboard. In the Middle West and Far West the nursing home has become a more sophisticated unit of the health team. Many new structures are built to meet the nursing-home function and are equipped with modern conveniences and safety features. They no longer cater to the aging ill alone. It has been reported that some homes have patients as young as five years of age. The average age of the patients in the nursing homes is in the low 60's, and will soon go lower. The patient load is made up largely of the chronically ill and disabled of all ages. This type institution is not "a road's end" station but a health facility fitting into the medical
What next for electronic communication and health care?
Authors: Alejandro R Jadad, Tony Delamothe
Journal: BMJ (2004)

What next for electronic communication and health care?New tools that require new thinking T he past decade has brought a range of electronic communication tools that promised to improve health care.As editors of this theme issue, we invited submissions describing how these innovations had lived up to their promise. 1These are our reflections on what we did and did not receive.
Absorption and secretion by the colon.
Authors: J H Cummings
Journal: Gut (1975)

Electrolytes and WaterThe role which the colon plays in conserving water and electrolytes has been known for some time, deduced largely from a comparison of the volume and composition of ileostomy effluent with that of faeces and confirmed by perfusion of the colon in vivo.The quantity of these substances absorbed daily by the colon has, however, to be revised, since it has been shown that the flow of ileal contents into the colon each day is three times the normal volume of ileostomy effluent (Kanaghinis, Lubran, and Coghill, 1963;Phillips and Giller, 1973).Fasting ileal flow rates, measured by slow intestinal on July 23,
Significant Improvement of the Survival of Seminoma Cells In Vitro by Use of a Rat Sertoli Cell Feeder Layer and Serum-Free Medium
Authors: J. C. Berends, S. E. Schutte, F. M. F. van Dissel-Emiliani, D. G. de Rooij, L. H. J. Looijenga, J. W. Oosterhuis
Journal: JNCI Journal of the National Cancer Institute (1991)

Seminoma cell lines, essential to the study of the biology of seminoma, do not exist. Tissue culture conditions for establishing such cell lines have to be developed. Under conventional culture conditions, seminoma cells usually die within the first 3 days after plating. The enhanced survival of rat gonocytes when cocultured with rat Sertoli cells in serum-free medium suggests that seminoma cells, the neoplastic counter parts of gonocytes, might benefit from the same conditions. Indeed, when cocultured with rat Sertoli cells in a serum-free medium, viable seminoma cells could be demonstrated on the 11th day of culture. This result is a significant improvement over the results with conventional methods. [J Natl Cancer Inst 83:1400–1403, 1991]
Cancer
Authors: Elizabeth H. Wood, James H. Doroshow
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-192: Circulating tumor cell clusters are precursors of breast cancer metastasis
Authors: Nicola Aceto, Aditya Bardia, Joel A. Spencer, Ben S. Wittner, Min Yu, Maria C. Donaldson, Adam Pely, Amanda Engstrom, Huili Zhu, Brian W. Brannigan, Ravi Kapur, Shannon L. Stott, Toshi Shioda, Sridhar Ramaswamy, David T. Ting, Charles P. Lin, Mehmet Toner, Daniel A. Haber, Shyamala Maheswaran
Journal: Cancer Research (2014)

Abstract The metastatic spread of breast cancer, typically to bone, lung, liver and brain, accounts for the vast majority of cancer-related deaths. Breast cancer metastases are thought to be derived primarily from individual migratory cancer cells, reaching distant sites through the bloodstream and initiating proliferation within distant organs. In addition to these single circulating tumor cells (CTCs), CTC-clusters have been detected in the blood of patients with cancer. In patients with breast cancer, we find that presence of such CTC-clusters is correlated with decreased progression-free survival. To study their functional role, we used mouse models, demonstrating that breast cancer cells injected intravascularly as clusters are more prone to survive and colonize the lungs than similarly injected single cancer cells. Primary orthotopic mammary tumors comprised of differentially tagged cells give rise to oligoclonal CTC-clusters, with 40-fold increased metastatic potential to the lung, compared with single CTCs. Using in vivo flow cytometry, we show that CTC-clusters are rapidly cleared from peripheral vessels, consistent with their trapping in small capillaries. Together, our observations suggest that primary tumor cells break off into the vasculature as CTC-clusters, and exhibit greatly enhanced metastatic propensity. Citation Format: Nicola Aceto, Aditya Bardia, Joel A. Spencer, Ben S. Wittner, Min Yu, Maria C. Donaldson, Adam Pely, Amanda Engstrom, Huili Zhu, Brian W. Brannigan, Ravi Kapur, Shannon L. Stott, Toshi Shioda, Sridhar Ramaswamy, David T. Ting, Charles P. Lin, Mehmet Toner, Daniel A. Haber, Shyamala Maheswaran. Circulating tumor cell clusters are precursors of breast cancer metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-192. doi:10.1158/1538-7445.AM2014-LB-192
Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus.
Authors: R J DeHoratius, R P Messner
Journal: Journal of Clinical Investigation (1975)

57% of sera from 124 relatives of 28 patients with systemic lupus erythematosus (SLE) were found to have antibody directed against lymphocytes. The incidence in 60 members of 16 control families was 3%. Both consanguineous and nonconsanguineous relatives had the antibody in their sera. 68% of close household contacts of the SLE patients showed lymphocytotoxic antibody whereas only 23% of consanguineous relatives who had no household contact with the probands had this antibody. These data suggest that environmental factors may be important in the pathogenesis of SLE.
Is HIV Prophylaxis Effective for Sexual Exposures?
Authors: Cori Vanchieri
Journal: Annals of Internal Medicine (1998)

Currents15 March 1998Is HIV Prophylaxis Effective for Sexual Exposures?Cori VanchieriCori VanchieriSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail By releasing guidelines for prophylactic treatment for sexual exposures to HIV, two San Francisco researchers hope that the lessons learned from treating occupational exposures can provide a sufficient road map. They recognize that the routes diverge in places but feel the need to act now.Meanwhile, they and others are starting the pilot studies that must be done before anyone can determine whether postsexual exposure prophylaxis (PEP) can block seroconversion. They are initially investigating how access to prophylaxis will affect behavior and whether people at risk for HIV can maintain the strict multidrug regimen.As the feasibility studies begin, Mitchell ... Author, Article, and Disclosure InformationAuthors: Cori Vanchieri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1998Volume 128, Issue 6Page: 513-514KeywordsBehaviorDrugsHIVHealth care providersHuman sexual behaviorPilot studiesPostexposure prophylaxisPrevention, policy, and public healthProphylaxisTreatment guidelines ePublished: 15 August 2000 Issue Published: 15 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Insulin binding to monocytes in trained athletes: changes in the resting state and after exercise.
Authors: V A Koivisto, V Soman, P Conrad, R Hendler, E Nadel, P Felig
Journal: Journal of Clinical Investigation (1979)

Insulin binding to monocytes was examined in trained athletes (long distance runners) and in sedentary control subjects in the resting state and after 3 h of exercise at 40% of maximal aerobic power. At rest, specific binding of 125-I-insulin to monocytes was 69% higher in athletes than in sedentary controls and correlated with maximal aerobic power. The increase in insulin binding was primarily due to an increase in binding capacity. During acute exercise, insulin binding fell by 31% in athletes but rose by 35% in controls. The athletes had a smaller decline in plasma glucose and a lower respiratory exchange ratio during exercise than did controls. We conclude that physical training increases insulin binding to monocytes in the resting state but results in a fall in insulin binding during acute exercise. Changes in insulin binding in athletes thus may account for augmented insulin sensitivity at rest as well as a greater shift from carbohydrate to fat usage during exercise than is observed in untrained controls.
Lymphocyte reactivity in rheumatoid arthritis. Mixed lymphocyte culture.
Authors: E M Caperton, D R Baker, R A King
Journal: Annals of the Rheumatic Diseases (1975)

Lymphocyte function in rheumatoid arthritis has been assessed by the mixed lymphocyte culture assay. In contrast to previous studies, no difference was found between lymphocytes from healthy volunteers and patients with rheumatoid arthritis. An occasional patient's lymphocytes failed to respond on a given day, but were normal on restudy. All 44 arthritic patient's lymphocytes underwent blast transformation on stimulation with lymphocytes from unrelated donors. By reaction in mixed lymphocyte culture, lymphocytes from patients with rheumatoid arthritis appear to be normal and no different from normal cells studied simultaneously.
Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes
Authors: Christian Herder, Eric J. Brunner, Wolfgang Rathmann, Klaus Strassburger, Adam G. Tabák, Nanette C. Schloot, Daniel R. Witte
Journal: Diabetes Care (2008)

OBJECTIVE—Interleukin-1 receptor antagonist (IL-1Ra), a natural inhibitor of interleukin-1β, has been shown to improve β-cell function and glycemic control in patients with type 2 diabetes. The aim of this study was to investigate whether baseline systemic levels of IL-1Ra are associated with incident type 2 diabetes during more than 10 years of follow-up. RESEARCH DESIGN AND METHODS—We measured serum IL-1Ra concentrations in a nested case-control study (181 case and 376 age-, sex-, and BMI-matched normoglycemic control subjects) within the Whitehall II cohort (U.K.). RESULTS—IL-1Ra concentrations were higher in case subjects (P = 0.0006) and associated with incident type 2 diabetes (odds ratio for a 1-SD increase of IL-1Ra 1.48 [95% CI 1.21–1.80]). This association remained significant after adjustment for multiple potential confounders but was attenuated by adjusting for 2-h glucose. CONCLUSIONS—Our findings indicate that individuals who will develop type 2 diabetes are characterized by a complex immune activation that also includes upregulation of the anti-inflammatory cytokine IL-1Ra.
Elevated serum hepatocyte growth factor/scatter factor levels in inflammatory lung disease.
Authors: J Maeda, N Ueki, T Hada, K Higashino
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Hepatocyte growth factor/scatter factor (HGF/SF) plays an important role in tissue repair in liver and renal damage. The clinical significance of this growth factor in these diseases has also been reported. The lung is one of the major sources of HGF/SF; because of this, we investigated serum HGF/SF levels in 26 patients with inflammatory lung disease (15 with interstitial pneumonitis [IP], 11 with bacterial pneumonia [BP]) by enzyme-linked immunosorbent assay. As controls, we measured HGF/SF in the serum of 13 stable outpatients with chronic respiratory failure. All patients had no significant liver or renal dysfunction. Serum HGF/SF levels were significantly elevated in patients with IP (1.16 +/- 0.22 ng/ml) or BP (0.96 +/- 0.27 ng/ml) compared with those in the control subjects (0.29 +/- 0.03 ng/ml, both p < 0.01). Serum HGF/SF levels in 14 healthy subjects were also studied, and the results (0.30 +/- 0.02 ng/ml) were not remarkably different from those of the control subjects. There were no significant correlations between serum HGF/SF levels and C-reactive protein and lactate dehydrogenase. Serum HGF/SF levels in the surviving patients rapidly decreased with treatment, but they did not change in the patients who ultimately died. Our results demonstrate the clinical significance of serum HGF/SF level as a useful indicator of prognosis in inflammatory lung disease.
Intramedullary fixation of femoral cortical osteotomies with interlocked biodegradable self-reinforced poly-96l/4d-lactide (SR-PLA96) nails
Authors: A. Saikku-Bäckström, R.-M. Tulamo, J.E. Räihä, T. Pohjonen, T. Toivonen, P. Törmälä, P. Rokkanen
Journal: Biomaterials (2003)