Fluconazole for Cryptococcal Meningitis
Authors: Roberto Esposito, Caterina Uberti Foppa, Spinello Antinori
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 January 1989Fluconazole for Cryptococcal MeningitisRoberto Esposito, MD, Caterina Uberti Foppa, MD, Spinello Antinori, MDRoberto Esposito, MDSearch for more papers by this author, Caterina Uberti Foppa, MDSearch for more papers by this author, Spinello Antinori, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-2-170_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapy for cryptococcal meningitis in patients with the acquired immunodeficiency syndrome (AIDS) is still unsatisfactory. Although other populations generally respond well to treatment with amphotericin B and flucytosine, patients with AIDS have a markedly lower cure rate (1). Moreover, after the initial therapy, long-term maintenance treatment with an antifungal agent is mandatory, because of the high frequency of recurrences. Weekly amphotericin B therapy has been recommended for this purpose, but Zuger and colleagues (2) show that some patients have relapses despite the administration of maintenance doses of the drug. On the other hand, the severity of side effects (including...References1. DismukesCloudGallis WGH. Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks. N Engl J Med. 1987;317:334-41. CrossrefMedlineGoogle Scholar2. ZugerSchusterSimberkoffRahalHolzman AMMJR. Maintenance amphotericin B for cryptococcal meningitis in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1988;109:592-3. LinkGoogle Scholar3. DupontDrouhet BE. Cryptococcal meningitis and fluconazole [Letter]. Ann Intern Med. 1987;106:778. LinkGoogle Scholar4. ByrneWajszczuk WC. Cryptococcal meningitis in the acquired immunodeficiency syndrome (AIDS): successful treatment with fluconazole after failure of amphotericin B. Ann Intern Med. 1988;108:384-5. LinkGoogle Scholar5. Dismukes W. Azole antifungal agents: old and new. Ann Intern Med. 1988;109:177-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Milan 20157 Milan Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFluconazole therapy of disseminated cryptococcosis in AIDS patients with liver cirrhosisInterpretation and management of PACT (prescribing analysis and cost) data on formularies.Interaction between fluconazole and rifampicin.Fluconazole: A New Triazole Antifungal AgentFluconazole Success after Amphotericin B and Flucytosine Failure in Cryptococcal MeningitisFluconazole, a New Antifungal AgentJohn N. Galgiani, MDManagement of Fungal Infection in Neutropenic Patients with Fluconazole 15 January 1989Volume 110, Issue 2Page: 170-170KeywordsAIDSAmphotericinAntifungalsCryptococcal meningitisDrug administrationDrug therapyPopulation statistics Issue Published: 15 January 1989 PDF downloadLoading ...