tbuckley/cabot-search huggingface dataset:
Lymphomatoid Granulomatosis Presenting as Fever of Unknown Origin
Authors: Charles C. Yockey
Journal: JAMA (1977)

IN 1972, Liebow et al<sup>1</sup>published a description of lymphomatoid granulomatosis (LYG), an angiocentric and angiodestructive lymphoreticular proliferative disorder that predominantly involves the lungs. We report a case that presented in a manner not previously described in literature. <h3>Report of a Case</h3> A 26-year-old man was admitted to USAF Hospital, Bitburg, Germany, on July 1, 1974, with complaints of fever, ataxia, diplopia, and a 4.5 kg weight-loss over a three-month period. On physical examination his body temperature was 38.3 °C orally. Axillary and inguinal adenopathy, hepatosplenomegaly, hyperactive deep tendon reflexes, ankle clonus, and Babinski's sign were present. Auscultation and percussion of the chest were unremarkable as was the chest roentgenogram. Hematocrit, alkaline phosphatase, creatinine phosphokinase (CPK), and total bilirubin levels were normal. Total WBC count ranged from 1,400 to 3,100/cu mm. Contrast roentgenogram of the upper gastrointestinal tract, SGOT, EEG, and biopsy specimens of the liver and right inguinal
Ionic Mechanisms of Regional Action Potential Heterogeneity in the Canine Right Atrium
Authors: Jianlin Feng, Lixia Yue, Zhiguo Wang, Stanley Nattel
Journal: Circulation Research (1998)

Abstract —Atrial action potential heterogeneity is a major determinant of atrial reentrant arrhythmias, but the underlying ionic mechanisms are poorly understood. To evaluate the basis of spatial heterogeneity in canine right atrial repolarization, we isolated cells from 4 regions: the crista terminalis (CT), appendage (APG), atrioventricular ring (AVR) area, and pectinate muscles. Systematic action potential (AP) differences were noted: CT cells had a “spike-and-dome” morphology and the longest AP duration (APD; value to 95% repolarization at 1 Hz, 270±10 ms [mean±SEM]); APG and pectinate muscle cells had intermediate APDs (180±3 and 190±3 ms, respectively; P &lt;0.001 versus CT for each), with APG cells having a small phase 1; and AVR cells had the shortest APD (160±4 ms, P &lt;0.001 versus other regions). The inward rectifier and the slow and ultrarapid delayed rectifier currents were similar in all regions. The transient outward K + current was significantly smaller in APG cells, explaining their small phase 1 and high plateau. L-type Ca 2+ current was greatest in CT cells and least in AVR cells, contributing to their longer and shorter APD, respectively. The E-4031–sensitive rapid delayed rectifier K + current was larger in AVR cells compared with other regions. Voltage- and time-dependent current properties were constant across regions. We conclude that myocytes from different right atrial regions of the dog show systematic variations in AP properties and ionic currents and that the spatial variation in ionic current density may explain AP differences. Regional variation in atrial ionic currents may play an important role in atrial arrhythmia generation and may present opportunities for improving antiarrhythmic drug therapy.
Accessible medical research
Authors: T. Groves
Journal: BMJ (2011)

New journal BMJ Open provides open access to even more research

The world’s first website was launched in August 1992 at info.cern.ch. With rapid growth of the world wide web over the following decade came the idea that articles reporting publicly funded research, particularly in health, ought to be accessible to anyone. Although many traditional publishers remain wary of this concept, at BMJ Group our approach has been to see what works best for readers, authors, and funders while still paying the bills. So, within two and a half years of the birth of the web, “eBMJ” was online at bmj.com, and in 1998 the BMJ became one of the first journals to provide full free access to all of its contents.

From 2005 bmj.com gradually introduced a pay wall for non-research articles, so that income from subscriptions could support continuing free access to research articles.1 In 2010 the BMJ introduced article processing fees for research articles, …
Introducing <i>New Strategies in...</i>
Authors: James L. Abbruzzese, Alexander M.M. Eggermont, Eric H. Rubin
Journal: Clinical Cancer Research (2010)

Article by Brian I. Rini, [p. 1348][1]

To further the mission of Clinical Cancer Research to be the bridge between the laboratory and the clinic, we are pleased to introduce in this issue of Clinical Cancer Research a new, organ-specific special feature that will present the latest, state-of-the-
Insurance-Industry Investments in Tobacco
Authors: J. Wesley Boyd, David Himmelstein, Steffie Woolhandler
Journal: New England Journal of Medicine (2009)

7 of these patients 3 ; there were overlaps between these two groups of patients.The cases of hypoglycemia reported in both articles pertained only to the sexual-enhancement drug called Power 1 Walnut.We did not cite these articles, and we regret these omissions.
Agrammatism, syntactic theory, and the lexicon: Broca's area and the development of linguistic ability in the human brain
Authors: Claudio Luzzatti, Maria Teresa Guasti
Journal: Behavioral and Brain Sciences (2000)

Grodzinsky's Tree-Pruning Hypothesis can be extended to explain agrammatic comprehension disorders. Although agrammatism is evidence for syntactic modularity, there is no evidence for its anatomical modularity or for its localization in the frontal lobe. Agrammatism results from diffuse left hemisphere damage – allowing the emergence of the limited right hemisphere linguistic competence – rather than from damage to an anatomic module in the left hemisphere.
Does hepatitis GB virus-C infection cause hepatocellular carcinoma in black Africans?
Authors: K Lightfoot, M Skelton, M C Kew, M C Yu, M Kedda, A Coppin, J Hodkinson
Journal: Hepatology (1997)

The newly cloned and characterized hepatitis GB virus-C (HGBV-C), which is the same virus as the independently discovered hepatitis G virus, has a global distribution, is transmitted parenterally, and causes chronic viremia. The pathological consequences of infection with HGBV-C are uncertain, and its hepatocarcinogenic potential is unknown. We used a case-control format to compare the prevalence of HGBV-C infection in 167 southern African blacks with hepatocellular carcinoma (HCC) and 167 race-, age-, and sex-matched hospital-based control subjects, and to test for possible interactive effects between this virus and hepatitis B and C viruses in the development of the tumor. The presence of HGBV-C ribonucleic acid was detected in serum samples by reverse transcription, amplification of the resulting complementary deoxyribonucleic acid by the polymerase chain reaction (PCR), and Southern hybridization using a probe from the NS3/helicase region of the genome. Serum samples were also tested for the presence of hepatitis B virus surface antigen, antibodies to hepatitis C virus, and hepatitis C virus ribonucleic acid. Individuals infected with HGBV-C did not have an increased relative risk of developing HCC (relative risk 0.9; 95% confidence limits 0.5, 1.7). Moreover, co-infection with HGBV-C did not further increase the risk of tumor development in patients who were chronically infected with hepatitis B and/or C viruses. HGBV-C is unrelated to hepatocellular carcinoma development in black Africans.
Radiolabeled Native Low-Density Lipoprotein Injected Into Patients With Carotid Stenosis Accumulates in Macrophages of Atherosclerotic Plaque
Authors: L. Iuliano, A. Mauriello, E. Sbarigia, L. G. Spagnoli, F. Violi
Journal: Circulation (2000)

Background —Accumulation of LDL within the arterial wall appears to play a crucial role in the initiation and progression of atherosclerotic plaque. The dynamic sequence of this event has not been fully elucidated in humans. Methods and Results —In 7 patients with previous transient ischemic attack or stroke and critical (&gt;70%) carotid stenosis, autologous native [ 125 I]-labeled LDL or [ 125 I]-labeled human serum albumin were injected 24 to 72 hours before endarterectomy. Carotid specimens obtained at endarterectomy were analyzed by autoradiography and immunohistochemistry. Autoradiographic study showed that LDL was localized prevalently in the foam cells of atherosclerotic plaques, whereas the accumulation in the lipid core was negligible. Immunohistochemistry revealed that foam cells that had accumulated radiolabeled LDL were mostly CD68 positive, whereas a small number were α-actin positive. No accumulation of the radiotracer was detected in atherosclerotic plaques after injection of radiolabeled human serum albumin. In 3 patients treated for 4 weeks with vitamin E (900 mg/d), an almost complete suppression of radiolabeled LDL uptake by macrophages was observed. Conclusions —This study shows that circulating LDL rapidly accumulates in human atherosclerotic plaque. The prevalent accumulation of LDL by macrophages provides strong support to the hypothesis that these cells play a crucial role in the pathogenesis of atherosclerosis.
A guide to microarray experiments-an open letter to the scientific journals
Authors: Catherine A Ball, Gavin Sherlock, Helen Parkinson, Philippe Rocca-Sera, Catherine Brooksbank, Helen C Causton, Duccio Cavalieri, Terry Gaasterland, Pascal Hingamp, Frank Holstege, Martin Ringwald, Paul Spellman, Christian J Stoeckert Jr, Jason E Stewart, Ronald Taylor, Alvis Brazma, John Quackenbush
Journal: The Lancet (2002)
Admissions to a U.K. teaching hospital with nonnecrotizing lower limb cellulitis show a marked seasonal variation
Authors: S.F. Haydock, S. Bornshin, E.C. Wall, R.M. Connick
Journal: British Journal of Dermatology (2007)

Journal Article Admissions to a U.K. teaching hospital with nonnecrotizing lower limb cellulitis show a marked seasonal variation Get access S.F. Haydock, S.F. Haydock Acute Medical Services, Box 275, Addenbrooke's Hospital, Hills Road, Cambridge CB4 2QQ, U.K. E‐mail: stephen.haydock@addenbrookes.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar S. Bornshin, S. Bornshin Acute Medical Services, Box 275, Addenbrooke's Hospital, Hills Road, Cambridge CB4 2QQ, U.K. E‐mail: stephen.haydock@addenbrookes.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar E.C. Wall, E.C. Wall Acute Medical Services, Box 275, Addenbrooke's Hospital, Hills Road, Cambridge CB4 2QQ, U.K. E‐mail: stephen.haydock@addenbrookes.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar R.M. Connick R.M. Connick Acute Medical Services, Box 275, Addenbrooke's Hospital, Hills Road, Cambridge CB4 2QQ, U.K. E‐mail: stephen.haydock@addenbrookes.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 5, 1 November 2007, Pages 1047–1048, https://doi.org/10.1111/j.1365-2133.2007.08124.x Published: 01 November 2007
Complementary medicine. Acupuncture has weak scientific foundations.
Authors: I S Johnson
Journal: BMJ (1993)

vascular granulomatosis or pulmonary "mainline" granulomatosis.'Symptoms include cough and dyspnoea, and in severe cases pulmonary hypertension is a consequence.Talc (magnesium trisilicate), a constituent of pentazocine, methyl- phenidate, and tripelennamine (tablets which are commonly injected) seems to be the agent most often implicated in such cases.Our evidence suggests that chronic misuse of injected temazepam may produce a similar pulmonary syndrome.We recently examined the lungs of a 31 year old drug misuser who died suddenly after an electromechanical dissociation cardiac arrest.He had admitted injecting a suspension of temazepam
EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity
Authors: Junli Yan, Siok-Bian Ng, Jim Liang-Seah Tay, Baohong Lin, Tze Loong Koh, Joy Tan, Viknesvaran Selvarajan, Shaw-Cheng Liu, Chonglei Bi, Shi Wang, Shoa-Nian Choo, Norio Shimizu, Gaofeng Huang, Qiang Yu, Wee-Joo Chng
Journal: Blood (2013)
Unusual Reaction to Penicillin in Oil and Wax
Authors: Clarence E. Burt, Sheldon M. Caplan
Journal: New England Journal of Medicine (1948)

AS new forms and combinations of penicillin have been developed, the reported incidence of hypersensitivity has also increased. Keefer1 states that the incidence of hypersensitivity following the use of amorphous penicillin in aqueous solution has varied between 2 and 5 per cent. Although there is a belief that hypersensitive reactions are somewhat greater when penicillin in peanut oil and beeswax is used, conclusive evidence is not yet available.2 Beeswax itself has been regarded as nonantigenic,3 but some authorities think that certain persons may become sensitized to it.1 Extensive studies have failed to show that pollen extracts are carried over in . . .
Intermittent Claudication With Pheochromocytoma
Authors: Yehuda Scharf
Journal: JAMA (1971)

Two patients with pheochromocytoma developed symptoms and signs of peripheral vascular disease, and in both cases, all peripheral pulses were palpable. At autopsy, no anatomical changes in the peripheral blood vessels could be found. These findings support the hypothesis that the circulatory changes were caused by excessive secretion of catecholamines. Symptoms and signs of peripheral vascular disease in the presence of palpable pulses in a hypertensive patient should raise the suspicion of pheochromocytoma.
Steroids for Idiopathic Sudden Sensorineural Hearing Loss
Authors: Jay F. Piccirillo
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ONTOGENY OF THE IMMUNE RESPONSE
Authors: G. M. Williams, G. J. V. Nossal
Journal: The Journal of Experimental Medicine (1966)

Polymerized flagellin from Salmonella adelaide was labeled with I125 and injected into rats varying in age from 0 to 42 days. Lymphoid organs were removed at various intervals and the progressive development of antigen-capturing structures was studied using autoradiography. The chief findings were as follows: 1. Newborn rats lack the follicular and medullary antigen-trapping structures characteristic of adult animals. 2. At the age of 10 to 14 days, the first signs of specific cortical antigen localization appear in lymph nodes. This initially takes the form of a continuous "cortical rim" of antigen localization. 3. Within a further 4 to 6 days, the Anlagen of true follicular antigen-capturing structures appear, the continuous rim being only a transitional mechanism. 4. The antigen-capturing part of the follicle appears before the lymphoid component; follicle Anlagen can be defined only on autoradiographs and cannot be seen on ordinary histological sections. 5. The system of medullary macrophages develops gradually over the period 2 to 6 weeks of age. 6. The ability of lymph nodes to retain antigen increases progressively, there being a fivefold increase in the amount of antigen retained per unit weight of lymphoid tissue between 2 and 6 wk of age.
Abstract 4470: The dual PI3K/mTOR inhibitor BEZ235 impairs gastric cancer growth in vitro and in vivo
Authors: Thorsten Füreder, Agnes Jaeger-Lansky, Doris Hoeflmayer, Claudia Kundtner, Thomas Wanek, Pamina Pflegerl, Volker Wacheck
Journal: Cancer Research (2010)

Abstract Background Gastric cancer is still a major health problem and the prognosis at advanced stage of disease with the current chemotherapeutic treatment strategies remains poor. Therefore novel treatment strategies and molecular targets for gastric cancer therapy are desperately needed. PI3K/mTOR pathway mutations, especially PTEN, PI3K3C and AKT mutations and pS6 overexpression, frequently occur in gastric cancer. Thus, we tested the activity of the dual PI3K and mTOR BEZ235 against gastric cancer in vitro and in vivo. Materials and Methods Three gastric cancer cell lines (N87, Mkn28 and MKN45) were treated with BEZ235 (20-80nM) and assessed for cell viability, cell death and cell cycle via celltiter blue and FACS analysis, respectively. PI3K/mTOR protein target modulation was measured by Western blotting. For in vivo studies athymic nude mice were inoculated with N87 or Mkn45 cells bilaterally and treated daily with 20 or 40mg/kg BEZ235. Results In vitro, treatment of gastric cancer cells with 20-80nM BEZ235 decreased cell growth in a dose dependent manner in all cell lines tested (up to −70%). This anti-proliferative activity was accompanied with a G1 cell cycle arrest of gastric cancer cells (up to 75%), whereas no significant levels of cell death were detected. On the molecular level, BEZ235 therapy resulted in a decrease of phosphorylation of AKT and S6 protein at 80nM. Notably, lower concentrations abolished mTOR downstream signalling but had no effect on AKT phosphorylation. In vivo, treatment with 20 and 40mg/kg BEZ235 resulted in a significant anti-tumor effect in a N87 gastric cancer xenograft mouse model. Interestingly, BEZ235 therapy displayed no anti-tumor activity in the MKN45 gastric cancer xenograft mouse model. In both models, we observed similar results in terms of PI3K/mTOR pathway downregulation in xenografts. Conclusion BEZ235 has pronounced anti-tumor activity in gastric cancer cells at low nanomolar range, which is linked with PI3K/mTOR downregulation and G1 cell cycle arrest. In vivo, N87 gastric cancer cells responded to BEZ235 treatment, whereas MKN45 cells were resistant. Thus, in our models in vitro sensitivity of BEZ235 did not predict for in vivo activity. We are currently conducting a microPET mouse study in order to evaluate whether PET is a suitable tool to predict BEZ235 sensitivity in vivo and the results will be presented at the meeting. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4470.
Intermittent Intravenous Procaine Amide to Treat Ventricular Arrhythmias
Authors: ELSA-GRACE V. GIARDINA
Journal: Annals of Internal Medicine (1973)

Twenty patients with ventricular arrhythmias were treated with procaine amide to determine an antiarrhythmic plasma drug concentration range and to observe procaine amide's effect on blood pressure and the electrocardiogram. Each received 100 mg of procaine amide intravenously every 5 minutes until arrhythmia was abolished, 1 g of drug was given, or untoward drug effects appeared. Arrhythmia was abolished in 17 patients and partially suppressed in 2 patients at a plasma drug concentration between 4 and 10 µg/ml; 1 patient did not respond. Therapy never had to be interrupted because of drug-induced hypotension, atrioventricular or intraventricular conduction disturbances, or arrhythmias. A strong linear relation was found between plasma procaine amide concentration and cumulative dose:- plasma procaine amide concentration (µg/ml) = 0.84 + 0.73x, where x is the cumulative procaine amide dose (mg/kg body weight). Intermittent intravenous procaine amide administration rapidly and safely produces antiarrhythmic plasma drug concentrations.
402. Intracellular Trafficking of QD-FRET Nanoparticles for Gene Delivery
Authors: Hunter H. Chen, Yi-Ping Ho, Tza-Huei Wang, Kam W. Leong
Journal: Molecular Therapy (2006)

Development of a safe and effective nonviral gene vector remains a significant challenge in the field of gene therapy. Rational design of more efficient gene carriers will be possible only with mechanistic insights of the rate-limiting steps in the nonviral gene transfer process. In order to examine the intracellular transport of DNA nanoparticles and their dissociated individual components, we have labeled nanoparticles with quantum dots (QD) and fluorescent organic dyes as a donor and acceptor pair for fluorescence resonance energy transfer (FRET). QDs have emerged as efficient FRET donors due to their broad absorption and narrow emission spectra, and high quantum yield, thus minimizing cross-talk between the donor and acceptor. Chitosan and plasmid DNA (pEGFP-C1) were individually labeled with a fluorescent organic dye and CdSe-ZnS quantum dots, respectively. Nanoparticles were subsequently formed by complex coacervation. Development of a safe and effective nonviral gene vector remains a significant challenge in the field of gene therapy. Rational design of more efficient gene carriers will be possible only with mechanistic insights of the rate-limiting steps in the nonviral gene transfer process. In order to examine the intracellular transport of DNA nanoparticles and their dissociated individual components, we have labeled nanoparticles with quantum dots (QD) and fluorescent organic dyes as a donor and acceptor pair for fluorescence resonance energy transfer (FRET). QDs have emerged as efficient FRET donors due to their broad absorption and narrow emission spectra, and high quantum yield, thus minimizing cross-talk between the donor and acceptor. Chitosan and plasmid DNA (pEGFP-C1) were individually labeled with a fluorescent organic dye and CdSe-ZnS quantum dots, respectively. Nanoparticles were subsequently formed by complex coacervation.
Prevalence of Cardiovascular and Renal Complications in Older Adults With Normal or Impaired Glucose Tolerance or NIDDM: A population-based study
Authors: Deborah L Wingard, Elizabeth L Barrett-Connor, Christa Scheidt-Nave, Janice B McPhillips
Journal: Diabetes Care (1993)

Objective— To determine the prevalence of CVD and renal disease by glucose tolerance status in a population-based study. Research Design and Methods— The study consisted of 991 men and 1243 women, aged 50-89 yr, living in the upper-middle class community of Rancho Bernardo, CA. All participants received a standard OGTT between 1984 and 1987. Results— A total of 159 men and 158 women had NIDDM, whereas 237 men and 348 women had IGT. Age-adjusted prevalence of complications generally was highest in those who were previously diagnosed with NIDDM. A significant correlation was observed between increases in the prevalence of complications and increases in glucose intolerance for microproteinuria, macroproteinuria, and myocardial infarction (borderline), as well as for stroke and claudication in men and myocardial infarction and stroke in women. In men with IGT or NIDDM, the age-adjusted prevalence of proteinuria and CVD was highest when other complications were present whereas in women such a prevalence was highest when other complications were absent. In men with diabetes, microproteinuria was associated with duration of disease. Conclusions— Prevalent CVD and renal disease were increased in adults with NIDDM and elevated in adults with IGT compared to those with normal glucose tolerance. The prevalence of complications in NIDDM subjects in this population-based study was substantially lower than that reported for clinic-based diabetic populations.