Hepatic Histologic and Immunohistochemical Changes in Chronic Hepatitis B after Prolonged Clearance of Hepatitis B e Antigen and Hepatitis B Surface Antigen
Authors: Robert P. Perrillo, Elizabeth M. Brunt
Journal: Annals of Internal Medicine (1991)

Brief Reports15 July 1991Hepatic Histologic and Immunohistochemical Changes in Chronic Hepatitis B after Prolonged Clearance of Hepatitis B e Antigen and Hepatitis B Surface AntigenRobert P. Perrillo, MD, Elizabeth M. Brunt, MDRobert P. Perrillo, MD, Elizabeth M. Brunt, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-2-113 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe treatment of chronic hepatitis B with recombinant alpha-interferon results in the disappearance of hepatitis B e antigen (HBeAg) and hepatitis B virus DNA (HBV DNA) from serum in nearly 40% of patients (1, 2). In addition, hepatitis B surface antigen (HBsAg) seroconversion occurs in approximately one third of responders (2). Improvement in serum aminotransferase levels and partial resolution of hepatic inflammation have been seen in most responders when evaluated 6 to 12 months after the completion of therapy (2-4). Whereas recent data indicate that the disappearance of serum markers for viral replication and improvement in liver function are often...References1. HoofnaglePetersMullen JMK. Randomized, controlled trial of recombinant human alpha interferon in patients with chronic type B hepatitis. Gastroenterology. 1988;95:1318-25. CrossrefMedlineGoogle Scholar2. PerrilloSchiffDavis REG. A randomized, controlled trial of interferon alfa-2b, alone and after prednisone withdrawal in the treatment of chronic hepatitis B. N Engl J Med. 1990;323:295-301. CrossrefMedlineGoogle Scholar3. BrookPetrovicMacDonaldScheuerThomas MLJPH. Evidence of histological improvement following antiviral treatment in chronic hepatitis B virus carriers and identification of histological features that predict response. In: Zuckerman AJ, ed. Viral Hepatitis and Liver Disease. New York: Alan R. Liss, 1988:906-8. Google Scholar4. PerrilloRegensteinPeters RFM. Prednisone withdrawal followed by recombinant alpha interferon in the treatment of chronic type B hepatitis. Ann Intern Med. 1988;109:95-100. LinkGoogle Scholar5. KorenmanBakerWaggoner JBJ. Long-term remission of chronic hepatitis B after alpha-interferon therapy. Ann Intern Med. 1991;114:629-34. LinkGoogle Scholar6. KuhnsMcNamaraPerrilloCabalCampbell MARCC. Quantitation of hepatitis B viral DNA by solution hybridization: comparison with DNA polymerase and hepatitis B e antigen during antiviral therapy. J Med Virol. 1989;27:274-81. CrossrefMedlineGoogle Scholar7. KnodellIshakBlack RKW. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981;1:431-5. CrossrefMedlineGoogle Scholar8. Di BisceglieWaggonerHoofnagle AJJ. Hepatitis B virus deoxyribonucleic acid in liver of chronic carriers. Gastroenterology. 1987;93:1236-41. CrossrefMedlineGoogle Scholar9. MarcellinMartinot-PeignouxLoriot PMM. Persistence of hepatitis B virus DNA demonstrated by polymerase chain reaction in serum and liver after loss of HBsAg induced by antiviral therapy. Ann Intern Med. 1990;112:227-8. LinkGoogle Scholar10. KuhnsMasonMcNamaraPerrillo MAAR. Polymerase chain reaction in the detection of HBV DNA after HBsAg clearance in chronic hepatitis B. [Abstract]. Hepatology. 1990;12:904. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From St. Louis Veterans Affairs Medical Center and Washington University School of Medicine, St. Louis, Missouri. For current author addresses, see end of text. 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