Hypogammaglobulinemia
Authors: ANANDA S. PRASAD
Journal: Annals of Internal Medicine (1964)

Case Studies1 August 1964HypogammaglobulinemiaIodinated Gamma Globulin StudiesANANDA S. PRASAD, M.D., PH.D., M. A. ABOUD, M.R.C.P., D.C.H., A. SALAWI, M.D., ARTHUR R. SCHULERT, PH.D.ANANDA S. PRASAD, M.D., PH.D.Search for more papers by this author, M. A. ABOUD, M.R.C.P., D.C.H.Search for more papers by this author, A. SALAWI, M.D.Search for more papers by this author, ARTHUR R. SCHULERT, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-319 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBruton first described primary agammaglobulinemia in male children in 1952 (1). Soon after, this condition was reported in adult females (2-5). This led to the recognition of two types of primary agammaglobulinemia: the congenital type seen in male children and an acquired variety occurring in adults of both sexes. Since then, approximately 200 cases of both kinds have been reported (6). Subsequently it has been shown that these patients have small quantities of gamma globulin in their plasma, and therefore the condition properly should be designated as hypogammaglobulinemia (7, 8). According to Good, Zak, Condie, and Bridges (8), the clinical...References1. BRUTON OC: Agammaglobulinemia. Pediatrics 9: 722, 1952. MedlineGoogle Scholar2. PRASADKOZA ASDW: Agammaglobulinemia. Ann. Intern. Med. 41: 629, 1954. LinkGoogle Scholar3. SANFORDFAVOURTRIBEMAN JPCBMS: Absence of serum gamma globulins in an adult. New Eng. J. Med. 250: 1027, 1954. CrossrefMedlineGoogle Scholar4. ZINNEMANHALLHELLER HHWHBI: Acquired agammaglobulinemia. JAMA 156: 1390, 1954. CrossrefMedlineGoogle Scholar5. GRANTWALLACE GHWD: Agammaglobulinemia. Lancet, II: 671, 1954. CrossrefGoogle Scholar6. WOLF JK: Primary acquired agammaglobulinemia. New Eng. J. Med. 266: 473, 1962. CrossrefMedlineGoogle Scholar7. PRASADREINERWATSON ASECJ: Syndrome of hypogammaglobulinemia, splenomegaly and hypersplenism. Blood 12: 926, 1957. CrossrefMedlineGoogle Scholar8. GOODZAKCONDIEBRIDGES RASJRMRA: Clinical investigation of patients with agammaglobulinemia and hypogammaglobulemia. Pediat. Clin. N. Amer. 7: 397, 1960. CrossrefMedlineGoogle Scholar9. PEARCEPERINPANAYAGAM KMMS: Congenital idiopathic hypogammaglobulinemia. Arch. Dis. Child. 32: 422, 1957. CrossrefMedlineGoogle Scholar10. PRASADFLINK ASEB: Effect of carbon dioxide on concentration of calcium in an ultrafiltrate of serum obtained by centrifugation. J. Appl. Physiol. 10: 103, 1957. CrossrefMedlineGoogle Scholar11. GORDONSPENCER BDS: Hypogammaglobulinemia. JAMA 174: 269, 1960. CrossrefMedlineGoogle Scholar12. PRASADMIALEFARIDSCHULERTSANDSTEAD ASAZAHH: Zinc metabolism in normals and patients with the syndrome of iron deficiency anemia, hypogonadism and dwarfism. J. Lab. Clin. Med. 61: 537, 1963. MedlineGoogle Scholar13. VALLEE BL: Biochemistry, physiology and pathology of zinc. Physiol. Rev. 39: 443, 1959. CrossrefMedlineGoogle Scholar14. MARTINGORDONMCCULLOUGH CMRSNB: Acquired hypogammaglobulinemia in an adult. New Eng. J. Med. 254: 449, 1956. CrossrefMedlineGoogle Scholar15. MARTINGORDONFELTSMCCULLOUGH CMRSWRNB: Studies on gamma globulin. J. Lab. Clin. Med. 49: 607, 1957. MedlineGoogle Scholar16. GOOD RA: Disturbances in gamma globulin synthesis as "experiments of nature." Pediatrics 18: 109, 1956. MedlineGoogle Scholar17. GITLINJANEWAYAPTCRAIG DCALJM: Agammaglobulinemia, in Cellular and Humoral Aspects of the Hypersensitive States. Edited by LAWRENCE, H. S. Hoeber, New York, 1959. Google Scholar18. JANEWAYGITLIN CAD: The gamma globulin. Advances Pediat. 9: 65, 1955. Google Scholar19. HAVENSDICKENSHEETSBIERLYEBERHARD WPJJNTP: The half-life of I-131 labeled normal human gamma globulin in patients with hepatic cirrhosis. J. Immun. 73: 256, 1954. MedlineGoogle Scholar20. ARMSTRONGKUKRALHERSHMANMCLEODWOLTER SHJJKJ: Comparison of the persistence in the blood of gamma globulin labeled with S35 and I131 in the same subjects. J. Lab. Clin. Med. 44: 762, 1954. Google Scholar21. VAUGHANARMATOGOLDTHWAITBRACHMANFAVOURBAYLES JHAJCPCBTB: A study of gamma globulin in rheumatoid arthritis. J. Clin. Invest. 34: 75, 1955. CrossrefMedlineGoogle Scholar22. VOLWILERGOLDSWORTHYMACMARTINWOODMACKAYFREMONT-SMITH WPDMPPAIRK: Biosynthetic determination with radioactive sulfur of turnover rates of various plasma proteins in normals and cirrhotic man. J. Clin. Invest. 34: 1126, 1955. CrossrefMedlineGoogle Scholar23. WIENERGORDON ASEB: Studies on human serum gamma globulin. J. Lab. Clin. Med. 49: 258, 1957. MedlineGoogle Scholar24. GITLIN D: Some concepts of plasma protein metabolism. Pediatrics 19: 657, 1957. MedlineGoogle Scholar25. LUCK JM: "Turnover" of Plasma Proteins (editorial). Amer. J. Med. 20: 317, 1956. CrossrefMedlineGoogle Scholar26. LIPPINCOTTKORMANFONGSTICKLEYWOLINSHUGHES SWSCEWWL: Turnover of labelled normal gamma globulin in multiple myeloma. J. Clin. Invest. 39: 565, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cairo,, Nashville, TennesseeFrom the Medical Department of the U.S. Naval Medical Research Unit No. 3, Cairo, Egypt, U.A.R., the Division of Nutrition of the Departments of Medicine and Biochemistry, Vanderbilt University, Nashville, Tennessee, and the Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt, U.A.R.Supported by research contract Nonr-2149 from the Office of Naval Research and by a grant from the National Institutes of Health, United States Public Health Service, Bethesda, Maryland.The opinions and assertions contained in this paper are those of the authors and are not to be construed as official or reflecting the views of the Navy Department, the naval service at large, or the Egyptian Ministry of Public Health.Requests for reprints should be addressed to Ananda S. Prasad, M.D., Department of Medicine, Wayne State University College of Medicine, Detroit 7, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1964Volume 61, Issue 2Page: 319-325KeywordsBiochemistryBlood plasmaChildrenExcretionGlobulinsHemolytic anemiaMedical servicesNutritionPrevention, policy, and public health Issue Published: 1 August 1964 PDF downloadLoading ...