tbuckley/cabot-search huggingface dataset:
ME researcher accused of cooking the books
Authors: C. Dyer
Journal: BMJ (1997)

An authority on chronic fatigue syndrome has been accused of “cooking” the results of research linking the syndrome to organophosphates in a case awaiting judgment in the High Court in London.

Peter Behan, professor of neurology at Glasgow University and honorary consultant neurologist to teaching hospitals in Glasgow, admitted there was an error in a paper published last year in the Journal of Nutritional and Environmental Medicine . Professor Behan was an expert witness for John Hill, a former farm worker bringing a test case for compensation for organophosphate poisoning.

Mr Hill is …
Letter: Non-union of the scaphoid.
Authors: F C Dwyer
Journal: BMJ (1974)

the experience of a sighted person.Blind- foldinig will give some idea of the physical disabilities of the blind but no idea of the heightening of his other senses which he may eventually employ.It cannot reproduce the emotional background.We are so used to "eye to eye" relationships with our fellows that we inevitably feel insecure at our first meeting with someone with whom this is impossible.As for teaching, I do not foresee any im- provement in the situation as less and less time becomes available for specialized teach- ing of this sort.The task of equipping the family doctor ito anticipate the odd ophthalmnic disaster is bound to take pre- cedence over training him for all but the most rudimentary aspects of care and rehabilitation of the blind and partiallysighted.Nevertheless, the family practitioner musit have confident recourse to others who can supply this expertise, and such others will be grateful to Dr. Shaw for helping their understanding.-Iam, etc.,
Pulsatile Stretch Stimulates Superoxide Production in Human Aortic Endothelial Cells
Authors: Keiichi Hishikawa, Thomas F. Lüscher
Journal: Circulation (1997)

Free radicals such as superoxide and nitric oxide (NO) play a key role in the pathophysiology of atherosclerosis. Mechanical forces such as pulsatile stretch may be involved in free radical production. We studied superoxide production by pulsatile stretch in human endothelial cells.Human cultured aortic endothelial cells were exposed to pulsatile stretch up to 24 hours, and superoxide production was examined. Short-term stretch for 1 hour (10% average elongation, 50 cycles per minute) increased superoxide production 2.2-fold. This effect was reduced by diphenyleneiodonium chloride, an NADPH oxidase inhibitor, but not by the xanthine oxidase inhibitor oxypurinol or the cyclooxygenase inhibitor indomethacin. Prolonged stretch up to 6 hours increased superoxide production, but it returned to near the control level after 24 hours of stretch. However, after blockade of NO production, 24 hours of stretch did increase superoxide production 2.4-fold compared with 24 hours of stretch alone. Moreover, 24-hour stretch doubled NO synthase (NOS) (III) protein and mRNA expression. The tetrahydrobiopterin synthesis inhibitor 2,4-diamino-6-hydroxypyrimidine had no effect on unstretched cells but doubled superoxide production compared with 24-hour stretch alone; this increase was halved by cotreatment with 6-methyl-5,6,7,8-tetrahydropterine, a lipid-soluble form of tetrahydrobiopterine.Short-term stretch increased superoxide production from human aortic endothelial cells via NADPH oxidase and NOS (III), whereas prolonged stretch increased both superoxide and NO production. The increase in NOS (III) protein with prolonged stretch acts as a scavenger mechanism whereby NO inactivates superoxide. Tetrahydrobiopterin determines the balance of superoxide and NO production from NOS (III) after prolonged stretch in which NOS (III) level is upregulated.
Doctor might escape conviction on a technicality
Authors: J. Ciment
Journal: BMJ (1998)

A contentious legal struggle that is likely to be settled on narrow technicalities rather than broad ethical questions has emerged over the assisted suicide of Thomas Youk. The 52 year old man from Michigan, United States, had amyotrophic lateral sclerosis, an inoperable disease of the nervous system that is popularly known as Lou Gehrig's disease.

Jack Kevorkian, 70, the Michigan doctor who claims to have assisted the suicides of over 130 terminally ill patients, faces up to seven …
Problems in the Early Recognition of Congenital Hip Dislocation
Authors: G. Walker
Journal: BMJ (1971)

Seven cases of infants whose hips were clinically normal at birth, and in whom hip dislocation was later recognized, are reported. In spite of the widespread practice of routine examination of the hips of newborn babies, infants and young children are still presenting with congenital dislocation of the hip. This is probably owing to there being two aetiological types. Every opportunity to re-examine the hips of children under 2 or even 3 years of age must be taken and a high level of suspicion maintained.
Reply from Authors re: Alexandre Mottrie, Marco Borghesi, Vincenzo Ficarra. Is Traditional Laparoscopy the Real Competitor of Robot-assisted Partial Nephrectomy? Eur Urol 2012;62:1034–6 and Reply from Authors re: Anthony T. Corcoran, Alexander Kutikov, Robert G. Uzzo. Meaningful Comparison of Robotics Versus Laparoscopy for Nephron-sparing Surgery: No Contest or No Dice? Eur Urol 2012;62:1037–8
Authors: Omar M. Aboumarzouk, Jihad H. Kaouk, Remi Eyraud, Georges-Pascal Haber, Piotr L. Chlosta, Bhaskar K. Somani, Robert J. Stein
Journal: European Urology (2012)
Bromocriptine in Congestive Heart Failure
Authors: WIJDAN LUQMAN
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 December 1985Bromocriptine in Congestive Heart FailureWIJDAN LUQMAN, M.D.WIJDAN LUQMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-958_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Bromocriptine has been reported to be useful in 33% to 86% of patients with acromegaly (1). Increases in cardiac stroke volume and lowering of peripheral resistance have also been seen with it (2, 3). We report the case of a patient who presented with frank pulmonary edema.A 65-year-old woman had been diagnosed in the past at another institution as having acromegaly but refused neurosurgical or radiation treatment. She had had subtotal parathyroidectomy for hyperparathyroidism, but no evidence of pancreatic tumor was found on celiac angiography. She had history of severe congestive heart failure for several years....References1. VANCEEVANSTHORNER LWM. Bromocriptine. Ann Intern Med. 1984;100:78-91. LinkGoogle Scholar2. FRANCISGOLDSMITHLEVINEOLIVARICOHN GSTMJ. The neurohumoral axis in congestive heart failure. Ann Intern Med. 1984;101:370-7. LinkGoogle Scholar3. CLARK B. Dopamine receptors and the cardiovascular system. Postgrad Med J. 1981;57(suppl 1):45-54. MedlineGoogle Scholar4. CAREYVAN LOONBAINESKAISER RGAD. Suppression of basal and stimulated noradrenergic activities by the dopamine agonist bromocriptine in man. J Clin Endocrinol Metab. 1983;56:595-602. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kuwait University Kuwait, Arabian Gulf PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1985Volume 103, Issue 6_Part_1Page: 958-958KeywordsAcromegalyAngiographyEdemaHeart failureHyperparathyroidismParathyroidectomyStroke Issue Published: 1 December 1985 PDF DownloadLoading ...
Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels
Authors: Robert T. Eberhardt, Lillian McMahon, Stephen J. Duffy, Martin H. Steinberg, Susan P. Perrine, Joseph Loscalzo, Jay D. Coffman, Joseph A. Vita
Journal: American Journal of Hematology (2003)

Abstract The purpose of the study was to examine endothelium‐dependent and ‐independent vasodilation of conduit and resistance vessels in sickle cell anemia (HbSS). We measured the effects of intra‐arterial infusion of methacholine, sodium nitroprusside, and N G ‐monomethyl‐L‐arginine (L‐NMMA) on forearm blood flow using venous occlusion plethysmography in eight patients with HbSS and 11 HbAA controls. We assessed vasodilation of the conduit brachial artery using ultrasound in 17 patients with HbSS and 41 nonanemic controls. Forearm blood flow response to methacholine was similar in HbSS and HbAA, while the response to sodium nitroprusside was greater in those with HbSS. Nitric oxide synthase inhibition with L‐NMMA attenuated methacholine‐induced forearm blood flow to a lesser extent in HbSS compared to HbAA, suggesting diminished nitric oxide (NO) contribution to endothelium‐dependent vasodilation. Flow‐mediated and nitroglycerin‐induced dilation were impaired in HbSS compared to controls and were not affected by the antioxidant vitamin C or the precursor substrate for NO synthesis L‐arginine. NO bioactivity is reduced but differs in peripheral conduit and resistance vessels in HbSS. Resistance vessels have preserved response to exogenous NO donors but have diminished contribution of NO to endothelium‐dependent vasodilation. Conduit vessels demonstrate impaired vasodilation to endogenous and exogenous NO. Am. J. Hematol. 74:104–111, 2003. © 2003 Wiley‐Liss, Inc.
Anesthetic actions within the spinal cord: contributions to the state of general anesthesia
Authors: J.G. Collins, Joan J. Kendig, Peggy Mason
Journal: Trends in Neurosciences (1995)

The behavioral state known as general anesthesia is the result of actions of general anesthetic agents at multiple sites within the neuraxis. The most common end point used to measure the presence of anesthesia is absence of movement following the presentation of a noxious stimulus. The actions of general anesthetics within the spinal cord have been shown to contribute significantly to the suppression of pain-evoked movements, an important component of clinical anesthesia. Studies in the spinal cord are likely to increase our understanding of the pharmacology by which general anesthetics alter the transmission of somatomotor information. It now appears that the pharmacology responsible for the production of anesthesia is agent- and site-selective, and not the result of a unitary mechanism of action.
Large Thrombus Originating From Left Atrial Diverticulum
Authors: Takayuki Nagai, Akira Fujii, Kazuhisa Nishimura, Katsuji Inoue, Jun Suzuki, Teruhito Kido, Michitsugu Nakamura, Yuji Matsumoto, Hironori Izutani, Teruhito Mochizuki, Kanji Kawachi, Jitsuo Higaki, Akiyoshi Ogimoto
Journal: Circulation (2011)
Regulation of interleukin-2 and interferon-γ gene expression in renal failure
Authors: Lisya Gerez, Liora Madar, Tamar Shkolnik, Batya Kristal, Gila Arad, Ayelet Reshef, Asnat Steinberger, Mali Ketzinel, Dror Sayar, Shaul Shasha, Raymond Kaempfer
Journal: Kidney International (1991)
Improved Specificity of Prone Versus Supine Thallium SPECT Imaging
Authors: GEORGE M. SEGALL, MICHAEL J. DAVIS, MICHAEL L. GORIS
Journal: Clinical Nuclear Medicine (1988)

A 56-year-old man without a history of myocardial infarction was referred for a SPECT thallium exercise study following successful angloplasty of the right coronary artery. The study showed a fixed defect in the inferior wall when the patient was imaged supine. However, when the patient was imaged prone the defect was no longer seen. Decreased inferior and inferoseptal activity is a frequent artifact seen in SPECT thallium myocardial perfusion studies. The finding has been variously attributed to attenuation of myocardial activity by the diaphragm or by the interposition of abdominal viscera, as well as patient motion and excessive myocardial motion due to diaphragmatic excursion, so called "upward creep." This is the first case that demonstrates that the specificity of a SPECT thallium study may be improved by imaging the patient prone instead of supine. Improved specificity is most likely due to better separation of the diaphragm and inferior wall, similar to the improvement seen in planar studies when patients are imaged in the right lateral decubitus position.
Congenital malformation associated with intrauterine contraceptive device.
Authors: H Barrie
Journal: BMJ (1976)

Two infants with fibular aplasia and related limb-reduction defects were born to mothers who were using copper-containing intrauterine contraceptive devices. The possibility of a casual association is consistent with the known hazards of intrauterine devices and cannot be excluded on the available experimental evidence. More information is urgently needed, and searches, including radiography of placenta and pelvis, should be made for such devices in mothers who have used them in the past and who give birth to malformed infants.
PREVENTING ADVERSE CONCUSSION OUTCOMES: THE ONLINE CONCUSSION AWARENESS TRAINING TOOLKIT (CATT)
Authors: S Babul, P Korn, R Goldman, I Pike, C Hay
Journal: British Journal of Sports Medicine (2014)

Background Concussion recognition, treatment and management is crucial in supporting recovery and decreasing the risk of long-term brain damage. Long-term effects are often not recognized early enough to prevent post-concussion syndrome, resulting in an impact on social and professional lives. The need to standardize care is vital in preventing adverse concussion outcomes. Objective To determine if concussion knowledge, attitudes and practices (KAP) are significantly improved among physicians and nurses following completion of CATT. Design A pre/post-intervention questionnaire designed to measure changes in physician/nurse KAP. Setting Primary setting was hospital emergency departments in the Lower Mainland, British Columbia. Participants Physicians/nurses working in emergency departments/trauma care facilities. Intervention Based upon established international principles, CATT is an online toolkit ( www.cattonline.com ) providing learner-directed concussion awareness training for health practitioners as well as assessment resources (SCAT3, Child-SCAT3), links to clinical resources, patient handouts, journal articles (including the Zurich Consensus Statement), related websites, concussion videos and study cases. Main outcome measures Change in physician/nurse knowledge, attitudes and practices regarding concussion recognition, treatment and management. Results 44 physicians and 35 nurses were recruited. Post-intervention questionnaires were completed by 34 physicians (77.3%) and 25 nurses (71.4%). Physicians demonstrated a statistically significant positive change in concussion practices (P=.001). Change in physician knowledge was not significant, while attitudes had a negative change (P=.041). Positive change in physician knowledge was detected for those who typically see more than 10 concussions per year (P=.039). Nurses demonstrated statistically significant positive change in practices (P=.005) and attitudes (P=.035), but no change in knowledge. Conclusions CATT is effective in improving concussion knowledge and practices among physicians and nurses, which will potentially minimize adverse concussion outcomes and lower health care costs among concussion patients. Phase 2 includes a toolkit for Parents, Players and Coaches, currently undergoing an evaluation with sporting associations in BC.
Spinal-cord compression in myeloma.
Authors: W J Benson, J H Scarffe, I D Todd, M Palmer, D Crowther
Journal: BMJ (1979)

Clinical records of 47 patients in whom spinal-cord compression was the presenting feature of plasma-cell myeloma were analysed retrospectively. Patients were referred during 1954-78. Median survival was 30 months and prognosis was best for those in whom the site of cord compression was the thoracic region. Early laminectomy and decompression followed by adequate radiotherapy resulted in complete or good partial response in over a third of patients who presented with complete paraplegia. Improvements in supportive care and more effective chemotherapy allow spinal-cord compression in myeloma to be treated promptly and vigorously, thus improving duration and quality of survival in a substantial proportion of patients.
Are Weekly Courses of Antenatal Steroids Beneficial or Dangerous?
Authors: Kellie E. Murphy, Mary Hannah, Peter Brocklehurst
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome after bronchiolitis depends on disease definition
Authors: M. Hyvarinen, M. Ruotsalainen, M. Korppi
Journal: Thorax (2010)

Thirdly, there are inconsistencies in the data in their figure 2. 1 Seven subjects have PD 20 values close to zero (possibly 0.1 mmol?), and therefore should have DRS values of w200 (ie, 20% fall/0.1 mmol) and CIR values of w2.3 (ie, log 200).These subjects do not appear in figure 2B,C.Furthermore, the distribution of AQLQ differs between figure 2A andB.The advantage of a continuous measure of airway responsiveness such as DRS, rather than PD 20 , is not that DRS provides qualitatively different information but rather that it yields an estimate of airway responsiveness in all subjects, not just the subset with AHR.Airway responsiveness is a continuum, with the cut-off point for AHR defined arbitrarily.However, AHR can be normalised with inhaled corticosteroid therapy, 3 and subjects with asthma can move in and out of the abnormal range.A more appropriate interpretation of the difference between PD 20 and 'reactivity' in their relationships with AQLQ reported by Cisneros et al 1 would be that quality of life is worse in subjects with AHR, but does not worsen with increasing severity of AHR.
Intradermal vs Intramuscular Hepatitis B Vaccinations
Authors: J. Wistrom, B. Settergren, A. Gustafsson, P. Juto, R. S. Norrby
Journal: JAMA (1990)

<h3>To the Editor.—</h3> A high response rate after intradermal (ID) vaccination with the plasma-derived hepatitis B vaccine has been demonstrated in several trials.<sup>1-3</sup>To study the immunogenicity of a DNA-recombinant hepatitis B vaccine we initiated a controlled, randomized, open trial in which 80 healthy medical students and hospital employees who gave verbal consent were randomized to either ID vaccination in the forearm with 2 μg or intramuscular (IM) vaccination in the deltoid muscle with 10 μg of DNA-recombinant hepatitis B vaccine (Recombivax-HB, Merck Sharp &amp;Dohme, West Point, Pa, expiration date December 1988). Vaccinations were performed by two experienced nurses at 0,1, and 6 months between December 1987 and September 1988. Hepatitis B surface antigen (HBsAg), antibody to hepatitis B core antigen, and antibody to HBsAg (expressed as international units [IU/L] according to the World Health Organization standard) were analyzed by radioimmunoassay. Thirty-eight subjects (20 women and 18 men) with a mean age of 30.1 years (range, 21 to 50 years) and 37 subjects (20 women and 17 men) with a mean age of 29.4 years (range, 20 to 55 years) could be analyzed for efficacy in the ID and IM groups, respectively.
Review: Oral drugs for gestational diabetes do not increase adverse maternal and neonatal outcomes more than insulin
Authors: Denice Feig
Journal: Annals of Internal Medicine (2009)

Source Citation Nicholson W, Bolen S, Witkop CT, et al. Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review. Obstet Gynecol. 2009:113:193-205. 19104375
Response to Comment on Hong et al. Effects of Metformin Versus Glipizide on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Coronary Artery Disease. Diabetes Care 2013;36:1304–1311
Authors: Jie Hong, Yifei Zhang, Shenghan Lai, Guang Ning
Journal: Diabetes Care (2013)

We thank Lund and Gong (1) for their letter and for taking an interest in our recent article (2). The following are responses to specific inquiries on the details of the trial. First, we respond to the statement that although our randomized clinical trial (RCT) is probably the first report of cardiovascular (CV) outcomes comparing the long-term effects of glipizide and metformin on the major CV events in type 2 diabetic patients who had a history of coronary artery disease, “several previous …
High dose heparin as pretreatment for primary angioplasty in acute myocardial infarction: the Heparin in Early Patency (HEAP) randomized trial
Authors: Aylee Liem, Felix Zijlstra, Jan Paul Ottervanger, Jan C.A Hoorntje, Harry Suryapranata, Menko-Jan de Boer, Freek W.A Verheugt
Journal: Journal of the American College of Cardiology (2000)
Dutch probiotics study is criticised for its "design, approval, and conduct"
Authors: T. Sheldon
Journal: BMJ (2010)

A joint investigation by three Dutch authorities has criticised the preparation and execution of a study of the use of probiotics in patients with acute pancreatitis.

Their two year investigation was launched ( BMJ 2008;336:296-7, doi:10.1136/bmj.39482.327350.C2) after it emerged that the mortality rate among the trial participants who had received the probiotics preparation was higher (24 of 152 participants died) than that among those who had received a placebo (nine of 144).

The Dutch Healthcare Inspectorate, the Central Commission on Research involving Human Participants, and the Food and Consumer Product Safety Authority now conclude that the study’s design, approval, and conduct had “major shortcomings.” Their …
Informing Patients About Total Hip Replacement-Reply
Authors: John Callaghan
Journal: JAMA (1996)

<h3>In Reply.</h3> —In response to Dr Hubers, Drs Toumbis and Nasser, and Dr Pottenger, I can only give them the benefit of the doubt that by not actually being at my presentation, seeing Mrs W, and listening to the discussion that occurred, much of the message was lost. However, if they would read the Clinical Crossroads article in detail, I believe they would agree that I adequately explained the pros and cons of hip replacement surgery to Mrs W. I think I explained all of the potential risks and benefits, especially the fact that Mrs W may not be able to perform simple tasks, such as putting on her shoes, after the surgery. I emphatically stated that only Mrs W could decide whether to have the surgery. My colleagues who commented after my presentation were trying to give the patient and her family perspective on various ways to evaluate her disease (osteoarthritis)