The Blood-cerebrospinal Fluid Barrier in Uremia
Authors: RICHARD B. FREEMAN
Journal: Annals of Internal Medicine (1962)

Article1 February 1962The Blood-cerebrospinal Fluid Barrier in UremiaRICHARD B. FREEMAN, M.D., MICHAEL F. SHEFF, PH.D., JOHN F. MAHER, M.D., GEORGE E. SCHREINER, M.D., F.A.C.P.RICHARD B. FREEMAN, M.D., MICHAEL F. SHEFF, PH.D., JOHN F. MAHER, M.D., GEORGE E. SCHREINER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-233 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients suffering from renal failure develop characteristic progressive signs of mental and neuromuscular dysfunction (1-3). The pathogenesis of these symptoms has been extensively studied, and numerous attempts have been made to correlate the symptomatology of uremia with the panorama of biochemical changes accompanying renal failure. The pathologic anatomy of the brain in uremia has also been thoroughly studied (4). Less attention has been paid to the chemistry of the cerebrospinal fluid (CSF) in uremia, and there has been virtually no evaluation of the integrity of the blood-brain barrier in uremic patients.The blood-brain barrier is a collective term for the...References1. SCHREINERMAHER GDJ: Uremia: Biochemistry, Pathogenesis, and Treatment. Charles C Thomas, Springfield, 1961. Google Scholar2. SALISBURYGRENELLSCHREINERSELIGSON PRGEDB: The nature of the uremic state (panel discussion). Trans. Amer. Soc. Artif. Intern. Organs 4: 178, 1958. Google Scholar3. SCHREINER GE: Mental and personality changes in the uremic syndrome. Med. Ann. D. C. 28: 316, 1959. MedlineGoogle Scholar4. KNUTSONBAKER JAB: The central nervous system in uremia. A clinico-pathological study. Arch. Neurol. Psychiat. 54: 130, 1945. CrossrefGoogle Scholar5. BAKAY L: The Blood Brain Barrier, Charles C Thomas, Springfield, 1956. Google Scholar6. DOBBING J: The blood brain barrier. Physiol. Rev. 41: 130, 1961. 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J. 60: 261, 1955. CrossrefMedlineGoogle Scholar14. BAUR M: Zur Pharmakologie des Harnstoffs. (Beitroge zum Problem der Urämie.) Arch. Exp. Path. Pharm. 167: 104, 1932. Google Scholar15. HENKINBYATTMAXWELL REPHMH: Evidence for the presence of a dialysable "toxic" factor in the sera of uremic patients. Clin. Res. 9: 202, 1961. Google Scholar16. SHEFFELLIOTT MFFA: Unpublished data. Google Scholar17. DAVSON H: Physiology of the Ocular and Cerebrospinal Fluids, J. & A. Churchill, Ltd., London, 1956. Google Scholar18. HARRISONMASONRESNIK TRMFH: Observation on the mechanism of muscular twitching in uremia. J. Clin. Invest. 15: 463, 1936. Google Scholar19. MASONRESNIKMINOTRAINEYPILCHERHARRISON MFHASJCTR: Mechanism of experimental uremia. Arch. Intern. Med. 60: 312, 1937. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Department of Neurology and the Division of Medicine of The Pennsylvania Hospital, Philadelphia, Pennsylvania, the Department of Medicine, Georgetown University School of Medicine, and the Renal and Electrolyte Division of the Georgetown University Hospital, Washington, D. C.Supported by grants from the John A. Hartford Foundation, Inc.Requests for reprints should be addressed to Richard B. Freeman, M.D., United States Public Health Service Hospital, 15th Avenue and Lake Street, San Francisco 18, Calif. 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A study of regional circulatory factors in squirrel monkeys.IN VITRO POLAROGRAPHIC STUDIES of RAT BRAIN OXYGEN UPTAKE IN SIMULATED URAEMIA and HEPATIC COMANeurologic Disorders in Renal FailureDisequilibrium Syndrome in HemodialysisDrug Selection and Dosage in Renal InsufficiencyUremia: Newer Concepts in Pathogenesis and TreatmentRenal DiseasePenicillin encephalopathyNeurologic disorders in renal failureHazards and Complications of DialysisThe effect of uraemic blood constituents on certain cerebral enzymesOliguric Renal Failure and Acute Tubular Necrosis 1 February 1962Volume 56, Issue 2Page: 233-240KeywordsAttentionBlood-brain barrierColony stimulating factorHospital medicineNeurologyPathogenesisProteinsRenal failureUreaUric acid Issue Published: 1 February 1962 PDF DownloadLoading ...