tbuckley/cabot-search huggingface dataset:
A numerical method for the calculation of the time constant of exponential functions
Authors: C. FRY
Journal: Cardiovascular Research (1993)

Journal Article A numerical method for the calculation of the time constant of exponential functions Get access CHRIS FRY CHRIS FRY Division of Physiology, UMDS (St Thomas' Campus), Lambeth Palace Road, London SE1 7EH, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 8, August 1993, Pages 1552–1553, https://doi.org/10.1093/cvr/27.8.1552 Published: 01 August 1993
EXPEDITIOUS, ACCURATE, ROENTGEN-RAY METHOD OF DETERMINING SEVENTH CERVICAL VERTEBRA
Authors: William J. Manning
Journal: JAMA (1924)

In cases of fracture or dislocation and other pathologic or traumatic conditions that may arise in the spinal column and vertebrae, it will be found most convenient to mark the seventh cervical vertebra in an unmistakable manner so that a lesion can be determined accurately and quickly in any given or specific vertebra as to numerical position by a count either toward or from this particular vertebra and a marking thereon, bearing in mind the various anatomic divisions, such as the seven cervical vertebrae, or the twelve thoracic or dorsal vertebrae. Lesions or foreign bodies existing in or on any organ manifested by roentgenogram within the thorax, larynx, or the lungs, diaphragm and abdomen can be accurately located in measured distances from the specific line on the surface and internally from the negative. The technic of procedure is very simple if either the first or the second method described is
Making Connexions: Enhancing the Therapeutic Potential of PatientClinician Relationships
Authors: Dale A. Matthews
Journal: Annals of Internal Medicine (1993)

Healers must try to understand what the illness means to the patient and create a therapeutic sense of connection in the patientclinician relationship. A favorable climate for connexional experiences can be created through the use of various interviewing techniques. Attending to rapport, silencing internal talk, accessing unconscious processes, and communicating understanding can help clinicians enhance their sensitivity to the subtle clues on which issues of meaning and connection often depend. Several risks are associated with the establishment of closer patientclinician relationships, including dependence and power issues, sexual attraction, and deeper exposure of the clinician to the patient's pain. Prepared with an awareness of these risks and techniques to address them, clinicians are encouraged to deepen their level of dialogue with patients, to compare their experiences with those of other clinicians, and to thereby develop a more systematic understanding of therapeutic relationships.
False-positive Liver Scan due to Ascites
Authors: MICHAEL G. VELCHIK
Journal: Clinical Nuclear Medicine (1985)

Extrahepatic structures (breast, costal margin, kidney, pleural effusion, right lower lobe lung mass) may occasionally result in a false-positive liver scan by causing attenuation of the gamma rays emenating from the liver, thereby simulating an apparent intrahepatic lesion. A false-positive diagnosis of intrahepatic pathology may often be avoided by simple maneuvers such as elevating the breast, obtaining another projection, etc. A case of false-positive liver scan due to loculated ascites is presented in which these maneuvers failed to resolve the problem. Ultrasound or CT examination may be helpful in this circumstance due to the cross-sectional nature of the information they provide.
Norepinephrine and Epinephrine Content of Normal and Diseased Human Hearts
Authors: WILHELM RAAB, WILDA GIGEE
Journal: Circulation (1955)

Because of the exquisitely oxygen-wasting and potentially hypoxia-producing effect of epinephrine on the myocardium, its relative (compared with norepinephrine) and absolute concentration in 85 human hearts was investigated. Significant increases above normal were found in cases of fresh myocardial infarction, in congestive heart failure, and in renal uremia. It is believed that the hypoxiating action of excess epinephrine in the heart muscle constitutes an important pathogenic factor in the origin of certain forms of functional and degenerative heart disease. Prolonged illnesses of various kinds seem to reduce the myocardial norepinephrine content.
INDICATIONS FOR TOTAL HYSTERECTOMY.
Authors: AUGUSTUS P. CLARKE
Journal: JAMA (1895)

I can vividly recall to mind the able discussion which took place at Washington in 1887, during the meeting of the Ninth International Medical Congress, on the subject of extirpation of the uterus for relief of carcinoma. Since that time my attention has been more particularly directed to the subject. At the time that the treatment of cancer by extirpation of the uterus was brought before the congress, I felt that the advocates of the measure had taken an advanced step. We all now recognize that the various procedures necessary in abdominal surgery have been more carefully considered and that the individual experiences have tended to do much toward placing that kind of work on a firmer basis. So far as statistics are concerned, as to the results of the different cases treated, they can not afford any very definite help, for in dealing with any case in which hysterectomy
Derek Julius Salfield
Authors: Stephen Salfield, Nicolas Salfield
Journal: BMJ (2006)

Former consultant child psychiatrist Derbyshire (b Berlin 1915; q Leipzig 1949; MD, FRCPsych, DPM), d 9 February 2006.

Born Kurt Joachim Dietrich Karl Julius Saalfeld, Dieter grew up in Berlin. He was permitted to study medicine in Leipzig as his mother was Aryan, but the Nazis prevented him from sitting finals as his father was Jewish. He escaped, unqualified, to the United Kingdom in 1938 and was interned. In 1945 he attained a BSc in psychology and worked as a clinical psychologist. Dieter returned to Leipzig in 1949 to take his medical finals. In the 1950s he trained in psychiatry, becoming consultant psychiatrist in Sedgefield and in 1955 the consultant child psychiatrist for Derby-shire. He leaves four children from his first marriage and three children from his second marriage.
Is the Dalkon Shield more dangerous than other IUCDs?
Authors: W Savage
Journal: BMJ (1985)

0742 580033), which can respond with support aind information very promptly.As with much else called psychiatry, it is true that doctors other than psychiatrists could cope.Laymen too can do most things that are needed, but others have not rushed in to help with this important sociopsvchological problem, and there may be a case for a centralised policy, very much influenced by psychiatrists, such as we have struggled to produce in Sheffield and, despite Dr O'Donnell, are hoping to maintain.We feel that prescrilping drugs of addiction comes close to colludipg with and maintaining the habit.The Sheffield police imply that the reduction in medical prescribing has probably helped to reduce other problems in the city and not increased them.
Ambulatory Electrocardiography
Authors: HAROLD L. KENNEDY
Journal: Annals of Internal Medicine (1977)

Advances in modern technology have made it possible to record and analyze the electrocardiographic data of ambulatory persons for as many as 24 h or more. This capability and an increasing awareness of cardiac dysrhythmias and myocardial ischemia as a cause of morbidity and mortality have led to the more widespread use of ambulatory electrocardiography in the examination of patients for various clinical conditions. From a clinical viewpoint, we review and summarize the present state-of-the-art of ambulatory electrocardiography and discuss when such studies are indicated, frequently warranted, or may be useful.
Thrombotic thrombocytopenic purpura in patients with human immunodeficiency virus infection: A report of three cases and review of the literature
Authors: Mark U. Rarick, Byron Espina, Robert Mocharnuk, Yvonne Trilling, Alexandra M. Levine
Journal: American Journal of Hematology (1992)

Three cases of thrombotic thrombocytopenic purpura (TTP) and coexistent human immunodeficiency virus (HIV) infection are presented with a review of 15 cases reported in the literature. Of the 18 total patients, one-half presented with no symptoms of HIV infection while nine patients presented with symptomatic HIV disease before or simultaneous to the diagnosis. The presenting symptoms were similar to those with classic TTP and included fever in 75% and 40% with neurologic symptoms. Laboratory parameters reflected the microangiopathic hemolytic anemia typically seen in patients with TTP. The median hematocrit was 19.4%, while the median platelet count was 16,000/mm3. As with classic TTP, patients with HIV-related TTP only had mild renal dysfunction (median creatinine of 1.2 mg/dl, range 0.8-4.8 mg/dl). Plasma exchange produced clinical remission in a majority of the patients. Importantly, approximately one-third of the patients died prior to the initiation of therapy. We conclude that TTP is a rare but treatable condition in patients with HIV infection. A TTP diagnosis should be considered in patients with HIV infection who present with severe anemia and thrombocytopenia. Plasma exchange should be considered as initial therapy. The role of both antiplatelet therapy and aspirin is unknown.
Hypertriglyceridemia and Atherosclerosis
Authors: Henry N. Ginsberg
Journal: Annals of Internal Medicine (1998)

Letters1 January 1998Hypertriglyceridemia and AtherosclerosisHenry N. Ginsberg, MDHenry N. Ginsberg, MDCollege of Physicians & Surgeons of Columbia University; New York, NY 10032Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-1-199801010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Despite my attempts to portray the complexity the issue and, therefore, make physicians aware that treatment was not based on data as good as those for LDL Cholesterol, Dr. Avins obviously feels that my editorial was misdirected. In response to the major points of the letter: First, I omitted a very important recent paper from Hokanson and Austin [1] from my editorial. This meta-analysis convincingly demonstrated that triglyceride levels are independent predictors of future coronary artery disease in both men and women [1] and is more recent than either the 1989 or 1995 reports Dr. Avins coauthored.Second, ...References1. Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol: a meta-analysis of population-based prospective studies. J Cardiovasc Risk. 1996; 3:213-9. Google Scholar2. Canner PL, Berge KG, Wenger NK, Stamler J, Friedman L, Prineas RJ, et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986; 8:1245-55. Google Scholar3. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, et al. Prevention of coronary heart diseases with prvastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995; 333:1301-7. Google Scholar4. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994; 344:1383-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: College of Physicians & Surgeons of Columbia University; New York, NY 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1998Volume 128, Issue 1Page: 74KeywordsCoronary heart diseaseDrugsEpidemiologyForecastingLipoproteinsLow density lipoproteinMortalityNiacinStable coronary artery diseaseStatins Issue Published: 1 January 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Combination treatment of non-segmental vitiligo with a 308-nm xenon chloride excimer laser and topical high-concentration tacalcitol: A prospective, single-blinded, paired, comparative study
Authors: Sang Ho Oh, Taegyun Kim, Hyunjung Jee, Jeong Eun Do, Ju Hee Lee
Journal: Journal of the American Academy of Dermatology (2011)
Current Perspectives on the Use of Alternative Species in Human Health and Ecological Hazard Assessments
Authors: Edward J. Perkins, Gerald T. Ankley, Kevin M. Crofton, Natàlia Garcia-Reyero, Carlie A. LaLone, Mark S. Johnson, Joseph E. Tietge, Daniel L. Villeneuve
Journal: Environmental Health Perspectives (2013)

Background: Traditional animal toxicity tests can be time and resource intensive, thereby limiting the number of chemicals that can be comprehensively tested for potential hazards to humans and/or to the environment.Objective: We compared several types of data to demonstrate how alternative models can be used to inform both human and ecological risk assessment.Methods: We reviewed and compared data derived from high throughput in vitro assays to fish reproductive tests for seven chemicals. We investigated whether human-focused assays can be predictive of chemical hazards in the environment. We examined how conserved pathways enable the use of nonmammalian models, such as fathead minnow, zebrafish, and Xenopus laevis, to understand modes of action and to screen for chemical risks to humans.Results: We examined how dose-dependent responses of zebrafish embryos exposed to flusilazole can be extrapolated, using pathway point of departure data and reverse toxicokinetics, to obtain human oral dose hazard values that are similar to published mammalian chronic toxicity values for the chemical. We also examined how development/safety data for human health can be used to help assess potential risks of pharmaceuticals to nontarget species in the environment.Discussion: Using several examples, we demonstrate that pathway-based analysis of chemical effects provides new opportunities to use alternative models (nonmammalian species, in vitro tests) to support decision making while reducing animal use and associated costs.Conclusions: These analyses and examples demonstrate how alternative models can be used to reduce cost and animal use while being protective of both human and ecological health.Citation: Perkins EJ, Ankley GT, Crofton KM, Garcia-Reyero N, LaLone CA, Johnson MS, Tietge JE, Villeneuve DL. 2013. Current perspectives on the use of alternative species in human health and ecological hazard assessments. Environ Health Perspect 121:1002–1010; http://dx.doi.org/10.1289/ehp.1306638
Cladribine in the treatment of systemic lupus erythematosus nephritis
Authors: V. KONTOGIANNIS, P. C LANYON, R. J POWELL
Journal: Annals of the Rheumatic Diseases (1999)

Cladribine in the treatment of systemic lupus erythematosus nephritisSystemic lupus erythematosus (SLE) nephritis often requires treatment with cyclophosphamide, which carries the risk of major side eVects including infection, ovarian failure and bladder malignancy.Therapeutic strategies that would specifically target lymphocytes are appealing.Following the first report of the use of the purine nucleoside analogue cladribine (2-chloro-2'deoxyadenosine), a selective lymphocyte depleting agent, in the treatment of lupus nephritis, 1 we report our experience in two patients with severe renal involvement.
Abstract LB-24: C-terminal PTEN is essential for maintenance of genomic stability and tumor suppression
Authors: Wen H. Shen, Yuxin P. Yin
Journal: Cancer Research (2014)

Abstract Tumor suppressor PTEN controls genomic stability and inhibits tumorigenesis. It is well established that the N-terminal phosphatase domain of PTEN dephosphorylates lipid PIP3 to PIP2, which antagonizes PI3K/AKT signaling. However, the C-terminal function of PTEN is much less defined. Here we describe a knock-in mouse model of a nonsense mutation that results in deletion of the entire Pten C-terminal region, referred to as PtenΔC. Mice heterozygous for PtenΔC develop multiple spontaneous tumors, including cancers of different origins and B cell lymphoma. We found that heterozygous deletion of the Pten C-terminal domain also causes genomic instability and common fragile site rearrangement. We found that Pten C terminal disruption induces p53 and its downstream targets, causing cell death by apoptosis. Simultaneous depletion of p53 promotes metastasis of thyroid cancer without influencing initiation of tumors, suggesting that p53 mainly suppresses tumor progression but not tumor initiation. This is the first evidence that PTEN and p53 plays distinct roles at different stages of tumor development. Our data highlight the essential role of the PTEN C-terminus in the maintenance of genomic stability and suppression of tumorigenesis. Finally, our work reveals a network of PTEN and p53 that controls cellular responses to environmental stresses. Citation Format: Wen H. Shen, Yuxin P. Yin. C-terminal PTEN is essential for maintenance of genomic stability and tumor suppression. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-24. doi:10.1158/1538-7445.AM2014-LB-24
Changing belief in iridology after an empirical study.
Authors: P. Knipschild
Journal: BMJ (1989)

200 auteurs d'articles dans des revues medicales sont interroges sur leur opinion sur la valeur de l'iridologie dans le diagnostic de certaines maladies. 83 d'entre eux ont repondu. Leurs opinions ont souvent change apres lecture d'un article niant la valeur de l'iridologie
Linking: a dynamic electrophysiologic phenomenon in macroreentry circuits.
Authors: M H Lehmann, S Denker, R Mahmud, A Addas, M Akhtar
Journal: Circulation (1985)

The term "linking" has been used specifically to describe the mechanism for perpetuation of functional anterograde bundle branch block: namely, repetitive transseptal retrograde concealed penetration by impulses propagating along the contralateral bundle. We present selected examples that demonstrate tht linking-type phenomena actually have a wide spectrum of expression in human macroreentry circuits, particularly those incorporating either the bundle branches and His bundle or the normal pathway and Kent bundle. The examples presented are as follows: (1) persistent retrograde functional conduction delays in the His-Purkinje system during right ventricular pacing, (2) anterograde Kent bundle condution at rapid rates, dependent on prior block in the normal pathway, (3) persistent anterograde functional infra-His block of atrial impulses during rapid ventricular pacing in the presence of a retrogradely conducting accessory pathway, and (4) transient advancement of His activation with ventricular fusion complexes during overdrive ventricular pacing of bundle branch reentrant tachycardia. Based on these examples, we characterize linking as a generalized electrophysiologic phenomenon in which each successive impulse entering a macroreentry circuit propagates preferentially along one limb because of functional block in the contralateral limb resulting from the effects of the prior impulse. It is proposed that such functional block may be dynamically maintained either by repetitive impulse interference, which perpetuates local refractoriness (examples No. 1 to 3), or by repetitive impulse collision (example No. 4). The general conceptual scheme outlined can be applied to specific electrophysiologic phenomena associated with a wide variety of reentry circuits in man.
Thirty years on: examination performance and career success of the 1950-1 intake of Cambridge medical students.
Authors: R Wakeford, S Roberts
Journal: BMJ (1983)

The relation between preclinical tripos and clinical examination results and subsequent career success of 188 medical graduates of Cambridge University was measured using five indicators of success. A generally positive relation was found, but this was not specific enough to make accurate individual predictions. Present levels of appointment were more closely related to clinical than preclinical results. No support was found for the local assertion that "2.1s" do better than "firsts" in clinical medicine. Since undergraduate examination results seem to be inaccurate predictors of later performance they should not be used as the principal evidence in making selection decisions.
Sequential Cardiorespiratory Events During and After Dextran-4O Infusion in Normal and Shock Patients
Authors: PATRICIA A. MOHR, DAVID O. MONSON, CYNTHIA OWCZARSKI, WILLIAM C. SHOEMAKER
Journal: Circulation (1969)

Sequential measurements of cardiac output, intravascular pressures, blood gases, pH, blood volume, and oxygen consumption were made in normal subjects and patients in shock before, during, and after infusions of dextran-40. In eight normal subjects the responses were: increased central venous pressure, increased cardiac index, decreased peripheral resistance, and decreased hemoglobin concentrations. These changes were of short duration and were attributed largely to increased plasma volume from the infusion. Nineteen of 26 patients in shock responded to administration of dextran-40 with increased central venous pressure, cardiac index, plasma volume, and central blood volume, as well as decreased mean transit time and total peripheral resistance. Lesser increases in blood pressure, stroke index, and left ventricular stroke work were observed. The increase in cardiac index was preceded by increased central venous pressure and decreased peripheral resistance. The hemodynamic changes were more marked and of longer duration than those of the normal subjects. In addition to these hemodynamic changes, dextran increased oxygen consumption in all but one of the patients whose major problem was hemorrhage and trauma. Increased oxygen consumption suggests that tissue perfusion improved after dextran possibly because of increased small vessel flow as well as increased plasma volume. In patients who were in shock because of sepsis, no change in oxygen consumption was observed despite hemodynamic improvement. As in the normal subjects, these hemodynamic changes were attributable to plasma expansion. In seven patients, dextran increased central venous pressure without improving cardiac index or other hemodynamic parameters. It is suggested that these patients were functioning with limited cardiac reserve.
Ultrasonically-guided Liver Biopsy
Authors: S. N. Rasmussen, H. H. Holm, J. K. Kristensen, H. Barlebo
Journal: BMJ (1972)

A method is described of fine-needle aspiration biopsy of liver metastases under direct guidance by ultrasonic scanning. Comparing the results with this technique and those with liver biopsy by Menghini9s method in 18 cases, we found that it was more accurate than the usual blind method.
Love is all you need..
Authors: D Carnall
Journal: BMJ (1994)

Well, what would happen if a senior house officer in a teaching hospital found himself endowed with miraculous powers to heal the sick? The Healer set out to explore this interesting idea, with mixed results.

Paul Rhys played Dr Lassiter, a shambling Irish doctor who emerges from three years in the wilderness to take on a senior house officer's job. After several minor miracles on sundry animals and old ladies, he hits the big time by healing a 5 year old boy of an intracranial haematoma. While the boy's duly grateful mother offers to endow the hospital with a £1.5 million MRI scanner, the …