tbuckley/cabot-search huggingface dataset:
John Hope Henderson
Authors: P. Kennedy
Journal: BMJ (2010)

At the age of 33, John Hope Henderson became physician superintendent of Elgin Hospital, embarking on a five year programme of ambitious and innovative community and hospital service modernisation. A few years later he became head of the much larger Bangour Village Hospital in East Lothian and continued reforming and modernising services. He became one of the early exponents of social psychiatry, in which clinical skills were melded with the ability to understand and respond to the social circumstances of patients and families. His influence on mental health in Scotland expanded further in 1974, …
Psychiatric Syndromes in Persian Gulf War Veterans: An Association of Handling Dead Bodies with Somatoform Disorders
Authors: Lawrence A. Labbate, Etzel Cardeña, Juliette Dimitreva, Michael Roy, Charles C. Engel
Journal: Psychotherapy and Psychosomatics (1998)

Traumatic combat experience has been associated with the development of posttraumatic stress disorder, but there have been few studies about the association of military combat experience and the development of somatoform disorders.The authors evaluated 131 referred Gulf War veterans for medical and psychiatric syndromes thought related to their involvement in the Gulf War. Patients completed questionnaires regarding their traumatic experiences and were interviewed using the Structured Clinical Interview for DSM III-R.For the sample, 69% had axis I conditions. Major depression, undifferentiated somatoform and posttraumatic stress disorders were the most common diagnoses. Reports of traumatic events were associated with both posttraumatic stress disorder (p < 0.05) and somatoform diagnoses (p < 0.05). Veterans who handled dead bodies had a 3-fold risk of receiving a somatoform diagnosis (p < 0.05).Psychiatric syndromes may explain some medical complaints following involvement in the Persian Gulf War. The results suggest that some psychological and nonspecific somatic symptoms persisting since the Gulf War may be related to exposure to psychological trauma.
A PATHOLOGIC STUDY OF SEVEN CASES OF PARALYSIS WITHOUT GROSS ANATOMIC CHANGE.
Authors: JOHN H. W. RHEIN
Journal: JAMA (1906)

Notwithstanding all these studies the cause of uremic hemiplegia has not been satisfactorily explained. One is forced to the conclusion that it may be due not to any one cause in all cases, but to one of a number of causes; in some cases, perhaps, to autointoxication; in others to edema or arteriosclerosis; and in still others to the presence of microscopic areas of necrosis which have been described in this paper. Some confusion seems to exist as to what really constitutes uremic hemiplegia. It is a mistake to diagnose all cases of one-sided paralysis occurring in a subject who suffers from chronic kidney disease, uremic paralysis. Strictly speaking, a diagnosis of uremic paralysis should be restricted to those cases which develop during uremia, transient palsy, or a palsy which may persist to the end in fatal cases. There is no way, however, that I know of, by which it
The Child With Congenital Heart Disease After Surgery
Authors: Grace S. Wolff
Journal: JAMA (1977)

This excellent volume brings together the papers presented at the 1975 Ontario Heart Foundation Symposium on Congenital Heart Disease. The book, divided into three sections, consists of contributions from outstanding physicians and surgeons knowledgeable in the care of the child with heart disease. Part 1 interweaves anatomical descriptions with surgical approaches to common as well as uncommon defects. There is extensive discussion of the tetralogy of Fallot and transposition of the great vessels, with special attention to the repair of these defects in early infancy. Additionally, the surgical problems of complex lesions (atrioventricular canal, tricuspid atresia, and single ventricle) are presented. Corrective and palliative procedures are analyzed from functional, anatomical, and hemodynamic perspectives. Part 2 continues the review of operative results and focuses on modes for evaluating these results. The authors consider the conventional investigative methods—ECGs, cardiac catheterization, and exercise testing—and also emphasize newer techniques. The chapters concerned with electrophysiology,
Changed Character of Osteomyelitis
Authors: R. L. Huckstep
Journal: BMJ (1967)

s hypothesis, which is also Poskanzer's,' is that early exposure to infec- ton in low risk areas prevents the later development of M.S.If this were true, how- ever, the "unexposed" immigrants should show a much higher attack rate than is found in their native lands, which seems not to be the case in Australia, Dutch Antilles, Israel, or South Africa.Further, the native-born English-speaking South Africans, as well as the Israelis, are recent arrivals, and from neither land do the current prevalence studies indicate any appreciable rate of M.S. in the parents of the subjects.Thus the evidence suggests that M.S. is " caught" in the high risk areas and brought by the migrants in a latent form into these low risk regions which provide such an invaluable human laboratory for M.S.What is the latent period can perhaps be better defined from the points raised here with the data available to Dr.
Abstract 356: Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer
Authors: Yun-Yong Park, Kyoungjyun Kim, Sang-Bae Kim, Bryan Hennessy, Soo Mi Kim, Eun Sung Park, Jae Yun Lim, Jane Li, Yiling Lu, Ana Gonzalez-Angulo, Gordon Mills, Stephen Safe, Ju-Seog Lee
Journal: Cancer Research (2011)

Abstract ESR1 is one of the most important oncogenes and therapeutic targets in breast cancer. By applying systems-level re-analysis of publicly available gene expression data, we uncovered potential regulator of ESR1. We demonstrated that orphan nuclear receptor NR2E3 regulates ESR1 via direct binding to the ESR1 promoter with concomitant recruitment of PIAS3 to promoter in breast cancer cells, and is essential for physiological cellular activity of ESR1 in estrogen receptor (ER)-positive breast cancer cells. Moreover, expression of NR2E3 was significantly associated with recurrence-free survival and favorable response to tamoxifen treatment in women with ER-positive breast cancer. Our results provide mechanistic insight into how ESR1 is regulated by NR2E3 and clinical relevance of NR2E3 in breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 356. doi:10.1158/1538-7445.AM2011-356
Bilateral lymphocytic alveolitis: a common reaction after unilateral thoracic irradiation
Authors: C. Martín, S. Romero, J. Sánchez-Payá, B Massutí, J.M. Arriero, L. Hernández
Journal: European Respiratory Journal (1999)

The main aim of the present study was to assess the early diagnostic value of bronchoalveolar lavage (BAL) in radiation-induced lung injury in patients with breast carcinoma. Twenty-six females receiving postoperative radiotherapy for breast cancer were evaluated before and 0, 15, 30, 60, and 180 days after radiotherapy. History, physical examination, chest radiographs, and pulmonary function tests were obtained. BAL, including lymphocyte subsets analysis, was limited to the second evaluation after radiotherapy. A group of 21 healthy females were used as control. Findings after radiotherapy in asymptomatic patients were compared with findings in a group of patients with radiation pneumonitis. Irradiated patients showed a significantly (p<0.01) greater percentage (29.5+/-15.7%) of BAL lymphocytes than controls (6.2+/-3.3%). No statistical differences existed in BAL findings between the irradiated and unirradiated sides of the chest. Percentages of BAL lymphocytes did not differ significantly between patients who developed subsequent pneumonitis (24.5+/-13.5%) and those who did not develop pneumonitis (32.8+/-16.5%). Patients with pneumonitis at the time of BAL had significantly higher (p<0.05) alveolar CD4 subset cells (24.8+/-10.2%) than asymptomatic patients (15.2+/-8.9%). Maximal reductions in total lung capacity (p<0.01), and residual volume (p<0.05) occurred 60 days after irradiation. The early lymphocytic alveolitis induced by unilateral thoracic radiotherapy in most patients with breast cancer is always bilateral and does not predict the subsequent development of radiological evidence of pneumonitis.
Abstract 207: Dual targeting of DLL4 and VEGF signaling by a novel bispecific antibody inhibits tumor growth and reduces cancer stem cell frequency
Authors: Wan-Ching Yen, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cecile Chartier, Marcus Fischer, Shirley Ma, Rene Meisner, Janak Raval, Jalpa Shah, Austin Gurney, John Lewicki, Timothy Hoey
Journal: Cancer Research (2014)

Abstract Both Notch/Delta-like ligand 4 (DLL4) and vascular endothelial growth factor (VEGF) pathways play a critical role in angiogenesis and tumor growth. Due to differential regulatory effects of VEGF and DLL4 on the vasculature, inhibition of DLL4 or VEGF inhibits tumor growth by distinct mechanisms: anti-DLL4 treatment induces an abnormal increase of poorly perfused blood vessels, which results in a nonproductive angiogenesis unable to support tumor growth, whereas the anti-VEGF therapy significantly decreases vasculature reducing the blood supply to tumors. We have recently developed a high binding affinity bispecific monoclonal antibody that targets both human DLL4 and human VEGF. In vitro, this antibody exhibited nanomolar affinity to hVEGF and hDLL4, and reduced HUVEC proliferation induced by VEGF. The bispecific antibody demonstrated significant in vivo anti-tumor efficacy in various solid tumors, delayed tumor recurrence following termination of chemotherapy, and decreased the frequency of tumor initiating cells. Analysis of tumor vasculature after treatment with anti-DLL4/VEGF revealed inhibition of vascular gene expression and endothelial cell proliferation, indicating that the anti-VEGF effect on the vasculature is dominant over the anti-DLL4 effect. Notably, at doses where both anti-DLL4 and anti-VEGF alone produced suboptimal anti-tumor effect, dual targeting resulted in additive tumor growth inhibition. These results indicate that our bispecific anti-DLL4/VEGF is broadly efficacious and may be useful for treatment of a variety of solid tumors. Citation Format: Wan-Ching Yen, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cecile Chartier, Marcus Fischer, Shirley Ma, Rene Meisner, Janak Raval, Jalpa Shah, Austin Gurney, John Lewicki, Timothy Hoey. Dual targeting of DLL4 and VEGF signaling by a novel bispecific antibody inhibits tumor growth and reduces cancer stem cell frequency. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 207. doi:10.1158/1538-7445.AM2014-207
Evaluation of new flexible bipolar hemostatic forceps in a randomized study
Authors: M Bergström, P-O Park, C Cunningham, GL Long, OJ Vakharia, GJ Bakos, KR Bally, P Swain, RI Rothstein
Journal: Endoscopy (2008)

Objective: A flexible bipolar hemostatic forceps „BELA“ to be used through the accessory channel (3.7 mm) has been developed by Ethicon Endosurgery. The aim of this study was to compare BELA with a laparoscopic hemostatic forceps (ERBE BiClamp 5 mm) in an acute porcine model.
A CASE OF PROBABLE GUMMATA OF THE LIVER IN A CHILD OF SIX.
Authors: MAURICE OSTHEIMER
Journal: JAMA (1903)

The case which I have the honor to report is that of a girl of 6, rather small and thin, but, according to her mother's account, always well except, temporarily, during attacks of measles and whooping cough. Her parents are both living, but are generally intoxicated; if only one be found, the other is probably "off on a spree." The father is a steady drinker and contracted syphilis about twenty years ago. Out of thirteen pregnancies, seven of which terminated by abortion, but two children are still living, a healthy man of 23 and this little girl. The others died between 3 and 10 years of age from various causes. No history of tuberculosis was obtainable. The patient, who was not living with her mother, was first brought to the dispensary of the University Hospital, July 21, 1902. She had complained of pain in her right side two weeks before;
Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis
Authors: Kepeng Wang, Min Kyoung Kim, Giuseppe Di Caro, Jerry Wong, Shabnam Shalapour, Jun Wan, Wei Zhang, Zhenyu Zhong, Elsa Sanchez-Lopez, Li-Wha Wu, Koji Taniguchi, Ying Feng, Eric Fearon, Sergei I. Grivennikov, Michael Karin
Journal: Immunity (2014)
Contractile Reserve and Calcium Regulation Are Depressed in Myocytes From Chronically Unloaded Hearts
Authors: Kenta Ito, Masaharu Nakayama, Faisal Hasan, Xinhua Yan, Michael D. Schneider, Beverly H. Lorell
Journal: Circulation (2003)

Background— Chronic cardiac unloading of the normal heart results in the reduction of left ventricular (LV) mass, but effects on myocyte contractile function are not known. Methods and Results— Cardiac unloading and reduction in LV mass were induced by heterotopic heart transplantation to the abdominal aorta in isogenic rats. Contractility and [Ca 2+ ] i regulation in LV myocytes were studied at both 2 and 5 weeks after transplantation. Native in situ hearts from recipient animals were used as the controls for all experiments. Contractile function indices in myocytes from 2-week unloaded and native (control) hearts were similar under baseline conditions (0.5 Hz, 1.2 mmol/L [Ca 2+ ] o , and 36°C) and in response to stimulation with high [Ca 2+ ] o (range 2.5 to 4.0 mmol/L). In myocytes from 5-week unloaded hearts, there were no differences in fractional cell shortening and peak-systolic [Ca 2+ ] i at baseline; however, time to 50% relengthening and time to 50% decline in [Ca 2+ ] i were prolonged compared with controls. Severe defects in fractional cell shortening and peak-systolic [Ca 2+ ] i were elicited in myocytes from 5-week unloaded hearts in response to high [Ca 2+ ] o . However, there were no differences in the contractile response to isoproterenol between myocytes from unloaded and native hearts. In 5-week unloaded hearts, but not in 2-week unloaded hearts, LV protein levels of phospholamban were increased (345% of native heart values). Protein levels of sarcoplasmic reticulum Ca 2+ ATPase and the Na + /Ca 2+ exchanger were not changed. Conclusions— Chronic unloading of the normal heart caused a time-dependent depression of myocyte contractile function, suggesting the potential for impaired performance in states associated with prolonged cardiac atrophy.
1116-8 Early and mid-term results of cypher stents in unprotected left main
Authors: Alaide Chieffo, Dejan Orlic, Flavio Airoldi, Iassen Michev, Matteo Montorfano, Nicola Corvaja, Ghada W Mikhail, Davide Maccagni, Antonio Colombo
Journal: Journal of the American College of Cardiology (2004)
Abstract 5642: Wound-healing drainages contribute to triple negative breast cancers aggressiveness
Authors: Francesca Bianchi, Marianna Sasso, Federica Turdo, Roberto Agresti, Cristina Ghirelli, Mattia Cremona, Rosaria Orlandi, Elda Tagliabue, Manuela Campiglio
Journal: Cancer Research (2012)

Abstract The triple negative breast cancers (TNBC) is an extremely aggressive cancer subtype that although account for only 10-17% of breast cancers carries the higher rate of distant recurrence and death than women with other breast cancer subtypes and, unfortunately has limited treatment options. The TNBC pattern of recurrence present a distant recurrence peak at approximately 3 years and then declines rapidly thereafter. It's now well known that growth-factors released during the healing process can accelerate the early recurrences in breast cancer patients. We speculate that wound healing drainages (WHD) stimulation may specifically contribute to TNBC early relapse. To this aim, a panel of TNBC cell lines (BT-549; HCC1937, MDA-MB-157; MDA-MB-231; MDA-MB-468; SUM159; SUM149) and the luminal cell lines MCF7 were treated with WHD. All breast carcinoma cell lines are induced to proliferate in response to more than 20 drainage fluids obtained from breast cancer patients, but median proliferation level was 3-folds higher in TNBC- compared to luminal-cell line. To identify which receptors/pathways can be activated and play a driving role in TNBC progression, a reverse phase protein microarray (RPMA) experiment on TNBC cells WHD stimulated was performed. We revealed a specific activation of PDGFR, VEGFR and their downstream pathways, whereas no significant changes were observed in other receptors, such as EGFR, IRS, Met and ERB3. Conversely, PDGFR and VEGFR pathways were not activated in MCF7. The type of activated receptors suggested the involvement of angiogenic properties, besides canonical proliferation pathways, upon WHD stimulation. To prove whether the receptors found activated by WHD play a key role in in vitro and in vivo TNBC progression, we targeted PDGFR, VEGFR and other receptors possibly involved in proliferation and angiogenic capabilities with sunitinib (targeting PDGFR, VEGFR, FGF and c-kit), anti-bFGF antibody (targeting the ligand bFGF) and bevacizumab (targeting the VEGF) in TNBC cells WHD-stimulated. Sunitinib and anti-bFGF antibody halved the proliferation of TNBC cell lines, whereas bevacizumab modestly affect proliferation. Notably, sunitinib and anti-bFGF antibody strongly inhibited MDA-MB-231 and MDA-MB-468 xenografts tumor growth (sunitinib: 80%, and 70% Growth Index (GI), respectively; anti-bFGF antibody 70% and 60% GI, respectively) whereas bevacizumab determined no more than 30% decrease of tumor volume. In conclusion, WHD promotes TNBC progression probably by sustaining both proliferation and angiogenic. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5642. doi:1538-7445.AM2012-5642
T Cell Recognition and Killing of Vascular Smooth Muscle Cells in Acute Coronary Syndrome
Authors: Sergey Pryshchep, Kayoko Sato, Jörg J. Goronzy, Cornelia M. Weyand
Journal: Circulation Research (2006)

Loss of vascular smooth muscle cells (VSMCs) has been proposed to destabilize the atherosclerotic plaque and contribute to plaque rupture, superimposed thrombosis, and acute coronary syndromes (ACSs). We examined whether VSMCs are susceptible to T cell-induced apoptosis and found that CD4 T cells are highly effective in establishing cell-cell contact with VSMCs and triggering apoptotic death. Visualization of the T cell-VSMC contact zone on the single-cell level revealed that both patient-derived and control CD4 T cells reorganized their cell membrane to assemble an immunologic synapse with the VSMCs. Within 4 to 10 minutes, the membrane proximal signaling molecule ZAP-70 was recruited and phosphorylated. However, only patient-derived CD4 T cells sustained an intact immunologic synapse beyond 10 minutes and generated intracellular calcium signals. CD4 T cells that maintained a synaptic contact and appeared to be responsible for VSMC apoptosis accounted for approximately 20% of the circulating memory T cell population in ACS patients and were rare in the blood of age-matched controls. CD4 T cells from ACS patients were also hyperresponsive to T cell receptor-mediated stimulation when triggered by a superantigen and non-VSMC target cells. Lowered setting of the T cell activation threshold, attributable to excessive amplification of proximal CD3-mediated signals, may contribute to CD4 T cell-mediated killing of VSMCs and promote plaque instability.
Myocardial Blood Flow and Oxygen Consumption during Postprandial Lipemia and Heparin-Induced Lipolysis
Authors: TIMOTHY J. REGAN, KENAN BINAK, SEYMOUR GORDON, VALENTINO DEFAZIO, HARPER K. HELLEMS
Journal: Circulation (1961)

The role of the physical state of plasma as a determinant of oxygen availability to the myocardium has been investigated during the course of alimentary lipemia. After the development of substantial plasma lactescence, the coronary blood flow (nitrous oxide method) and myocardial oxygen consumption were assessed in 7 normal human subjects and repeated after heparin-induced lipolysis. The lipemic state was further contrasted with a control fasting group, comparable in age and sex. The mean coronary blood flow for 15 fasting controls was 83 ml. per 100 Gm. of left ventricle per minute with a myocardial oxygen extraction of 11.04 volumes per cent, and a myocardial oxygen consumption of 9.0 ml. per 100 Gm. of left ventricle per minute. By contrast, the mean coronary blood flow during maximal lipemia in the 7 subjects fed cream was 20 per cent below normal, with a value of 67 ml. per 100 Gm. per minute ( p =&lt; 0.01). As the extraction of oxygen was not significantly affected, the calculated myocardial oxygen consumption was proportionately reduced to 7.02 ml. per 100 Gm. per minute ( p =&lt; 0.01). A failure of the anticipated oxygen extraction increment in the face of coronary blood flow reduction suggests an impediment of blood-tissue oxygen transport during lipemia. After the administration of 60 mg. of heparin to the 7 lipemic subjects, a 65 per cent decline in plasma lactescence was observed by 45 minutes, when the coronary blood flow and myocardial oxygen consumption were elevated to 87 ml. per 100 Gm. per minute ( p =&lt; 0.05) respectively. Thus, the reduced coronary flow and myocardial oxygen consumption were restored in each instance to normal levels during the process of plasma clearing. There were no associated systemic hemodynamic changes to account for such increments. These heparin effects appear dependent on the lipemia-clearing property, for no alteration in coronary dynamics was found in 6 additional patients in whom this activity was not manifest after the same heparin dosage. The residual lactescence after post-heparin lipolysis was associated with no significant deviation of coronary dynamics from the normal. That a concentration-dependent phenomenon is operative, was confirmed in a separate group of patients in whom low lactescence values developed in the course of alimentary lipemia without affecting myocardial oxygen consumption. The relevance of the lipemic state, per se, to the pathophysiology of myocardial ischemia appears to depend upon the establishment of an oxygen gradient within the myocardium, presumably through altered pressure-flow relationships produced by lipemic blood within a pathologic vessel.