tbuckley/cabot-search huggingface dataset:
Systemic mastocytosis in the elderly
Authors: Joseph H. Butterfield, Catherine R. Weiler
Journal: American Journal of Hematology (2013)

"Later onset" of systemic mastocytosis (SM) has been associated with a poorer prognosis. We examined clinical and laboratory findings, associated disorders, and survival in an older mastocytosis population. After receiving Mayo Clinic Institutional Review Board approval, we identified 42 patients aged 70 years and older at the time of diagnosis of SM. Associated disorders, cytogenetic abnormalities, laboratory findings, and survival were recorded. Only 10 patients had no associated hematologic disorder. Single or multiple chromosomal abnormalities, exclusive of the KIT Asp816Val mutation, were detected in eight patients (19%). KIT Asp816Val mutation was present in 14 patients, negative in three, and not tested in 25. Slight to marked bone marrow hypercellularity was observed in 33 patients (79%). Concurrent hematologic abnormalities included chronic myelomonocytic leukemia (n = 7), acute myelocytic leukemia (n = 1), myelodysplastic syndrome (MDS; n = 7), eosinophilia (n = 7), myelofibrosis (n = 1), myeloproliferative disorder (n = 1), multiple myeloma (n = 1), B-cell lymphoma (n = 1), and thrombocytopenia (n = 4). Eight patients had a hematologic disorder that preceded the diagnosis of SM. Tryptase levels were elevated in 38 of 39 patients tested. Survival from the diagnosis of SM was poor for patients with associated thrombocytopenia, leukemias, and MDS. In conclusion, patients with SM diagnosed at age 70 or older have an increased risk of secondary hematologic disorders and abnormal laboratory findings. Cytogenetic abnormalities are common, and survival is short in many SM patients with associated leukemias, MDS, or eosinophilia.
US bill proposes speeding up free online access to federally funded research
Authors: J. Lenzer
Journal: BMJ (2012)

A new bill in the US Congress would require all federally funded research to be placed online for free access within six months of publication, instead of the present 12 months.

The Federal Research Public Access Act comes on the heels of a heated battle over the Research Works Act, a bill introduced to Congress in December 2011 that would have prevented federal agencies from requiring researchers to freely disseminate their work without the publisher’s prior permission ( BMJ 2012;344:e452, doi:10.1136/bmj.e452).

The Research Works Act was initially supported by the global publishing giant Elsevier until late February, when it withdrew its support after widespread criticism of the act …
Abstract 3084: The role of RNA-binding protein HuR in lung metastasis of triple-negative breast cancer
Authors: Patsharaporn Techasintana, Matthew Michael Gubin, Joseph David Magee, Garrett MacKenzie Dahm, Ulus Atasoy
Journal: Cancer Research (2011)

Abstract Breast cancer is the second most common cancer among women worldwide. It is estimated that approximately one million women are diagnosed with breast cancer annually. Furthermore, more than 410,000 women will die each year from the disease primarily due to tumor metastasis. Currently, even the most effective treatments often result in recurrence and metastasis, in part due to genetic factors. Therefore, understanding the mechanism of breast cancer related gene regulation is crucial for the development of novel treatments and preventive strategies to those who are predisposed to developing breast cancer. Previously, we have shown that the RNA-binding protein HuR posttranscriptionally regulates various proto-oncogenes by stabilizing their mRNAs and facilitating their translation into proteins. Additionally, HuR upregulation and cytoplasmic localization has been associated with invasive cancer progression and poor prognosis. HuR has been described to control genes in multiple areas of the acquired capabilities model of cancer and has been hypothesized to be a tumor-maintenance gene, allowing for cancers to proliferate once they are established. HuR regulates genes involved in angiogenesis, cell growth and cell cycle regulation including VEGFα, TSP1, HIF1α, CDKN1A(p21) and β-catenin. In this study, we investigated the role of HuR in an aggressive triple-negative (estrogen receptor ER-, human epidermal growth factor receptor 2 (HER2)- and progesterone receptor (PR)-) breast cancer cell subline LM-2. The LM-2 cells were derived from triple-negative breast cancer cells MDA-MB-231 which were isolated from two rounds of in vivo selection of the cancer cells which metastasized to the lungs. The LM-2 cells were retrovirally transduced with triple-fusion protein reporter construct encoding thymidine kinase1, green fluorescent protein (GFP) and firefly luciferase in order to obtain nuclear imaging, fluorescent and bioluminescent properties for in vivo and in vitro tracking. LM2 cells were further transfected with a plasmid containing HA-HuR or empty vector control to investigate the function of HuR in LM2 cells. Two clones of HuR overexpressing LM2 cells were shown to grow faster in vitro compared to the empty vector control. Also, HuR overexpression significantly facilitates tumor invasion in vitro by matrigel invasion assay. Further analysis of HuR overexpressing LM2 cells using in vivo imaging system (IVIS) will reveal the role of HuR in breast cancer growth and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3084. doi:10.1158/1538-7445.AM2011-3084
116 A multicenter italian study of rescue adefovir dipivoxil therapy in lamivudine resistant patients: A 2-year analysis of 650 patients
Authors: P. Lampertico, A. Marzano, M. Levrero, T. Santantonio, P. Andreone, M. Brunetto, V. Di Marco, S. Fagiuoli, G. Mazzella, G. Raimondo
Journal: Journal of Hepatology (2006)
Anti-inflammatory drugs and bowel perforations and haemorrhage
Authors: J M Dixon, A B Lumsden
Journal: BMJ (1985)

several new perforations in the small bowel were repaired.Apart from the persistence of an entero- cutaneous fistula there were no further abdominal problems.Following three months of total paren- teral nutrition his fistula closed, and enteral feeding was reintroduced without any problems.
Amenorrhoea after Discontinuing Combined Oestrogen-Progestogen Oral Contraceptives
Authors: S. J. Steele, B. Mason, A. Brett
Journal: BMJ (1973)

Out of 210 women seen at the Middlesex Hospital with secondary amenorrhoea the 63 who developed it after stopping oral contraceptives were fully investigated. Five had organic disease sufficient to account for the amenorrhoea (one had severe diabetes, one a pituitary tumour, and three premature ovarian failure); two patients had galactorrhoea (one of whom also had the pituitary tumour); two had anorexia nervosa.Of the 63 women 40 (63%) had suffered from amenorrhoea or prolonged or irregular menstrual cycles before taking the pill, and this suggested that combined oestrogen-progestogen oral contraceptives should be used with caution for women with irregular menstruation.Nineteen patients wished to become pregnant and 12 have so far done so after treatment with clomiphene or gonadotrophins.In another study 204 women recorded when their first menstrual cycle occurred after stopping the pill. Seventy-four had a cycle longer than five weeks but only five exceeded three months, and only one of the five had more than six months' amenorrhoea. These results confirm that the incidence of amenorrhoea after stopping oral contraceptives is low.
Management of Pregnancy in Women With Immune Thrombocytopenic Purpura
Authors: Harry W. Carloss
Journal: JAMA (1980)

Immune thrombocytopenic purpura (ITP) may develop during pregnancy or affect later pregnancies. When this occurs, the obstetrician usually seeks the internist for help. The mother and fetus are at serious risk from thrombocytopenia and the measures that can control it. Case reports published since 1950 examine the pathogenesis of ITP and its special problems during pregnancy. Recommendations for management derive from these problems. (<i>JAMA</i>1980;244:2756-2758)
Endothelial progenitor cells are clonal and exhibit the JAK2V617F mutation in a subset of thrombotic patients with Ph-negative myeloproliferative neoplasms
Authors: Luciana Teofili, Maurizio Martini, Maria Grazia Iachininoto, Sara Capodimonti, Eugenia Rosa Nuzzolo, Lorenza Torti, Tonia Cenci, Luigi Maria Larocca, Giuseppe Leone
Journal: Blood (2011)
Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer
Authors: Jian-Guo Wang, Julia E. Geddings, Maria M. Aleman, Jessica C. Cardenas, Pichika Chantrathammachart, Julie C. Williams, Daniel Kirchhofer, Vladimir Y. Bogdanov, Ronald R. Bach, Janusz Rak, Frank C. Church, Alisa S. Wolberg, Rafal Pawlinski, Nigel S. Key, Jen Jen Yeh, Nigel Mackman
Journal: Blood (2012)
Letter from Eritrea.
Authors: J Black
Journal: BMJ (1983)

No 1 uniform, plus the lambskin gloves. And, or course, ? Os Od to my parachute rigger, who in retrospect was grossly under-rewarded. My claim to H M government was for the equivalent of $125, which an eagle eyed accounts section, in its wisdom, reduced to $75. In 1952 my wife and I returned to Annan. The airfield was difficult to find, and its very existence was apparently not known to the younger inhabitants of the area. We stood there, silently. The wind moaned, the grasses bent, low cloud scudded. We were chilled. Eerie feelings pervaded. We left.
Air pollution and short term mortality
Authors: E. Hennessy
Journal: BMJ (2002)

The widely held belief that European levels of air pollution might seriously affect human health has been hard to verify. Most studies investigate the immediate effects on mortality, comparing day to day variations in atmospheric pollutants, temperature, and humidity with variations in deaths. High and low temperatures increase mortality while the effects of cold at least are prolonged1 and temperature is associated with pollution. Most investigators attempt to adjust for this confounding, although methods vary. Because both relations are complex, simple adjustments for confounding may be inadequate and some or all the apparent effects of pollutants may be indirect associations caused by the effects of temperature. A recent paper by Keatinge and Donaldson now questions whether this is true for some recent studies such as those from the “air pollution and health—a European approach” (APHEA) project, citing sulphur dioxide as an example.2

Several reports suggest that atmospheric sulphur dioxide is associated with short term mortality, although the variability in results needs explanation. The APHEA project was designed to investigate this by, among other things, using several years of daily measurements from 15 European cities and standardised analyses.3 Katsouyanni et al concluded from it that rising sulphur dioxide levels increased mortality in western but not eastern Europe, although their results also varied.4 The protocol for temperature adjustment for …
Amenorrhoea in the Feeding Disorders: Anorexia Nervosa and Obesity
Authors: G.F.M. Russell, C.J. Beardwood
Journal: Psychotherapy and Psychosomatics (1970)

Serial urinary gonadotrophin measurements were made during dietary treatment of patients with anorexia nervosa and with obesity. Results indicate that food restriction and weight loss give rise to a general reduction in gonadotrophin excretion. An important endocrine feature of anorexia nervosa is a lack of cyclical gonadotrophin excretion even after normal body weight has been restored. This loss of rhythmicity cannot be accounted for simply in terms of weight loss. It is suggested, on the basis of reported animal studies, that the endocrine disturbance in anorexia nervosa may be due to a failure of the anterior hypothalamic mechanisms concerned with the control of rhythmic gonadotrophin secretion.
Incidence of Amyotrophic Lateral Sclerosis Among American Indians and Alaska Natives
Authors: Paul H. Gordon, Jason M. Mehal, Robert C. Holman, Lewis P. Rowland, Andrew S. Rowland, James E. Cheek
Journal: JAMA Neurology (2013)

Importance: More thorough evaluation of amyotrophic lateral sclerosis (ALS) and motor neuron disease in unique populations could provide clues to etiologies for these idiopathic conditions, and educational programs for American Indian and Alaska Native (AI/AN) people and health care professionals on reservations could improve awareness, understanding, diagnosis, and treatment.In the ongoing search for susceptibility genes, studying particular racial groups, such as AI/ANs, might facilitate the identification of new mutations.Objective: To provide better understanding of ALS and secondarily of motor neuron disease among AI/AN people by estimating the incidence and prevalence among AI/ANs served by the Indian Health Service health care system.Design and Setting: Analysis of electronic records for AI/ANs with ALS and with motor neuron disease separately for the calendar years 2002-2009 using inpatient and outpatient visit data from the Indian Health Service, which provides health care to eligible AI/ANs nationwide.Participants: Cases were defined by at least 2 inpatient or outpatient visits with the diagnosis.Main Outcome Measures: Crude and age-adjusted incidence and prevalence rates were calculated.Results: Seventy-one AI/ANs were diagnosed with ALS, yielding an average annual crude incidence rate of 0.63 cases per 100 000 and an age-adjusted incidence of 0.92.The median age at onset was 56.0 years and was higher among women than men (62.0 vs 55.0 years; P=.06).Agespecific incidence increased to 70 to 74 years.The crude and age-adjusted point prevalence rates were 2.00 and 4.12, respectively.The crude and age-adjusted incidence rates for motor neuron disease were 1.08 and 1.50, respectively.The annual rates were unchanged across the study period. Conclusions and Relevance:The incidence of ALS among AI/ANs appears to be lower than that reported for white populations, a finding congruent with reports of other minority populations.Community-based studies are important to confirm these findings and to examine reasons for the low rate of ALS among AI/ANs.
Antiretroviral treatment of HIV infected adults
Authors: Steven G Deeks
Journal: BMJ (2006)

It has been about 10 years since the first report that three drug combination antiretroviral therapy can durably suppress HIV replication. 1 Subsequent studies have confirmed that when used appropriately highly active antiretroviral therapy can suppress viral replication to such low levels that the virus is unable to generate drug-resistance mutations.Theoretically, once this level of viral suppression is achieved, treatment should work indefinitely, and the long term risk of morbidity and morality related to HIV associated immunodeficiency becomes negligible.Experience to date suggests that lifelong suppression of HIV is feasible.This review is aimed at informing clinicians about the current management of HIV infection.Authoritative and continuously updated reviews are available on the web (for example, the US Department of Health and Human Services treatment guidelines at www.hivatis.org);this review does not attempt to exhaustively summarise the literature or to provide guidance to clinicians with expertise in HIV.Rather, I summarise those issues that are likely to confront clinicians, including those who do not routinely treat people infected with HIV. Sources and selection criteriaI searched PubMed databases for studies pertaining to antiretroviral therapy and its complications, lipodystrophy and lipoatrophy, and immune reconstitution.I also consulted recently published national and international treatment guidelines and considered unpublished data presented at international meetings.
Everest, the Testing Place
Authors: Frederick L. Glauser
Journal: JAMA (1986)

<i>Everest, the Testing Place</i>by John B. West, MD, is a chronicle of the 1981 American research expedition to Mount Everest organized and led by Dr West, who is a professor of medicine and physiology at the University of California, San Diego. Dr West is recognized and respected for his pioneering work in ventilation perfusion relationships and high-altitude physiology. This expedition combined scientific objectives with the adventure of climbing at extreme altitudes and, in some ways, was a continuation of the 1960-1961 Himalayan scientific mountaineering expedition, of which Dr West was a member. Dr West begins his book by detailing the history of mountaineering with emphasis on scientific investigations at high altitudes. He then describes the challenging problems encountered in obtaining funding, selecting team members, developing new equipment for high-altitude cardiopulmonary research, and assembling and transporting the equipment. The trek to the base camp is detailed, as are the problems
THE "IMPRISONMENT PSYCHOSIS" WITH REPORT OF CASES
Authors: W. W. Richardson
Journal: American Journal of Psychiatry (1912)

1. The symptom-complex under discussion cannot be regarded as a disease entity. 2. It develops most often in the adolescent or young criminal. 3. While it may complicate other psychoses it very often occurs simply upon a markedly defective basis, which in some cases amounts to imbecility. 4. It is not infrequently associated with evidences of an attempt at simulation. 5. While related to hysteria in nature it can hardly be regarded as a hysterical psychosis, though of psychogenic origin. 6. Great apprehensiveness with partial stupor, hallucinations of sight and hearing, and often mutism are frequently the most prominent symptoms. Their rapid disappearance upon transfer to a hospital for insane is usual and striking.
A kidney from the family.
Authors: R G Simmons, K Hickey, C M Kjellstrand, R L Simmons
Journal: BMJ (1971)

Elsewhere in the Scottish report' Doctors in an Integrated Health Service it states that "the community medicine specialist could en- sure that rehabilitation and after-care were co-ordinated."Perhaps it would have been prudent, before pre-empting areas of rehabilitation for this new grouping of community medicine, to wait until the two committees which have been studying the place of re- habilitation within the Health Service for the past three years in England and Wales and in Scotland, under the chairmanship of Sir Ronald Tunbridge and myself respectively, had resorted.
Family Psychotherapy – a Frame of Reference for Choosing Methods of Treatment in a Psychiatric Hospital
Authors: Per Vaglum
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Family Psychotherapy – a Frame of Reference for Choosing Methods of Treatment in a Psychiatric Hospital Subject Area: Psychiatry and Psychology Per Vaglum Per Vaglum Gjettum Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 279–282. https://doi.org/10.1159/000286881 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Per Vaglum; Family Psychotherapy – a Frame of Reference for Choosing Methods of Treatment in a Psychiatric Hospital. Psychother Psychosom 31 December 1975; 25 (1-6): 279–282. https://doi.org/10.1159/000286881 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
CLINICAL FEATURES AND PROGNOSTIC FACTORS IN PATIENTS WITH TUBERCULOUS AND IDIOPATHIC PERICARDIAL EFFUSION
Authors: Suk-Won Choi, Jong-Min Song, Hyung Oh Choi, Sung-Ho Jung, Dae-Hee Kim, Duk-Hyun Kang, Jae-Kwan Song
Journal: Journal of the American College of Cardiology (2012)
Books on Sports Medicine
Authors: CLAUDE A. FRAZIER
Journal: Annals of Internal Medicine (1974)

Comments1 January 1974Books on Sports MedicineCLAUDE A. FRAZIER, M.D.CLAUDE A. FRAZIER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-1-121_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am currently editing three books: the prevention and treatment of the medical problems of golfers, the prevention and treatment of the medical problems of swimmers, and the prevention and treatment of sports medical problems in general. They are to be written by physicians for the sports-minded laymen. I would appreciate hearing from anyone wishing to contribute a chapter to any or all of these books or who would be able to suggest someone to contribute chapters to these books. Any replies should be sent to me at this address: 4-C Doctors' Park, Asheville, NC 28801.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1974Volume 80, Issue 1Page: 120-120KeywordsHearingSportsSports and exercise medicine ePublished: 1 December 2008 Issue Published: 1 January 1974 PDF downloadLoading ...