tbuckley/cabot-search huggingface dataset:
Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin
Authors: Don E. Eslin, Chunyan Zhang, Kathleen J. Samuels, Lubica Rauova, Li Zhai, Stefan Niewiarowski, Douglas B. Cines, Mortimer Poncz, M. Anna Kowalska
Journal: Blood (2004)
Individualization of Phenytoin Therapy
Authors: Victor R. Adebimpe
Journal: JAMA (1976)

To  Editor.—  Although it is well known that plasma levels are better than dosages in  assessment of clinical response to phenytoin, it is probably less widely recognized that  values of such levels given in textbooks and in  Physician's Desk Reference (PDR) are below  therapeutic range for some patients. 1,2   I recently treated a patient suffering from psychomotor seizures with increasing doses of phenytoin, deliberately aiming for  higher plasma levels recorded in  literature before considering a change to another medication.  Despite  absence of side effects, early signs of toxicity, or abnormalities in serial laboratory investigations (blood chemistry, hematology tests, ECG),  patient's rising levels of phenytoin were paralleled by  anxiety and panic of nurses, resident house staff, and fellow attending physicians, who were all concerned about this departure from the Gospel according to PDR .  As a result of  ensuing hue and
Tropical Infectious Diseases: Principles, Pathogens, and Practice
Authors: A. Clinton White, Robert L. Atmar, Stephen B. Greenberg
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes18 January 2000Tropical Infectious Diseases: Principles, Pathogens, and PracticeA. Clinton White Jr., MD, Robert L. Atmar, MD, and Stephen B. Greenberg, MDA. Clinton White Jr., MDBaylor College of Medicine and Ben Taub General Hospital, Houston, Texas. (White, Atmar, Greenberg)Search for more papers by this author, Robert L. Atmar, MDBaylor College of Medicine and Ben Taub General Hospital, Houston, Texas. (White, Atmar, Greenberg)Search for more papers by this author, and Stephen B. Greenberg, MDBaylor College of Medicine and Ben Taub General Hospital, Houston, Texas. (White, Atmar, Greenberg)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-2-200001180-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 2 volumes. Guerrant RL, Walker DH, Weller PF, eds. 1644 pages. Philadelphia: Churchill Livingstone; 1999. $295.00. ISBN 0443079080. Order phone 800-543-1918.Field of medicine: Infectious diseases and tropical medicine.Format: Two hardcover books.Audience: Specialists in infectious disease and tropical medicine; generalists who treat immigrants and travelers from developing countries; and practitioners in tropical countries.Purpose: To provide a comprehensive scholarly textbook on tropical infectious diseases.Content: The first section of the book discusses general considerations and noninfectious conditions. The second section covers individual bacterial, rickettsial, fungal, parasitic, and viral pathogens. Chapters on pathogens that are common worldwide (such as ... Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine and Ben Taub General Hospital, Houston, Texas. (White, Atmar, Greenberg) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agentsA Bibliometric Analysis of Global Scientific Research on Scrub Typhus 18 January 2000Volume 132, Issue 2Page: 168KeywordsHospital medicineInfectious diseasesPneumococcusSoftware toolsStaphylococcusStreptococcusToxinsTropical diseasesTuberculosisViral pathogens ePublished: 15 August 2000 Issue Published: 18 January 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Amphetamine facilitating Electrically Induced Convulsions
Authors: K. C. Bailey
Journal: BMJ (1943)

BMEITISHthe first case may have an underlying endocrinopathy as an aetiological factor.Endocrines and Ophthalmology In 1938 Sir Walter Langdon-Brown gave a lecture to the Oxford Ophthalmological Congress reviewing the ocular mani- festations of endocrinopathies as they present themselves to the ophthalmologist.Parathyroid, pineal, pituitary, thyroid, adrenal medullary, gonad, and pancreatic disorders may all show ophthalmological signs, and these may for a time be the presenting feature.Endocrines and Cancer Experiments in small animals, such as mice, indicate that oestrogens in large doses over long periods may,rinduce neo- plastic growth in genital and other organs.Thus Allen (1942) records cancer of cervix uteri (mice), uterine fibromyomas (guinea-pigs), mammary cancer (mice), interstitial cell tumours of the testis (mice), adenomatous tumours of the pituitary (rats and mice), tumours of the suprarenal cortex (mice), and osteogenetic transformations of bones including tumours (mice).Such neoplastic changes are not found in monkeys, and there is no clinical evidence of the endocrines being responsible for malignant changes in the genital or other organs in man.
Progress in the wrong direction
Authors: A P J Lake
Journal: BMJ (1991)

<h3>ABSTRACT</h3> Bio-instructive materials that prevent bacterial biofilm formation and drive an appropriate host immune response have the potential to significantly reduce the burden of medical device-associated infections. Since bacterial surface attachment is known to be sensitive to surface topography, we experimentally survey 2,176 combinatorially generated shapes using an unbiased high-throughput micro topographical screen on polystyrene. This identifies topographies that reduce colonization <i>in vitro</i> by up to 15-fold compared with a flat surface for both motile and non-motile bacterial pathogens. Equivalent reductions are achieved on polyurethane, a polymer commonly used in medical devices. Using machine learning methods, a set of design rules based on generalisable descriptors is established for predicting bacteria-resistant micro topographies. In a murine foreign body infection model, anti-attachment topographies are shown to be refractory to <i>P. aeruginosa</i> and to recruit a productive host response, highlighting the potential of simple topographical patterning of non-eluting implants for preventing medical device associated infections.
An Analysis of Two Thousand Consecutive Cases in Midwifery Occurring in Private Practice
Authors: G. Rigden
Journal: BMJ (1859)

conjectured that if, in addition to that, his breathing had been oppressed by compression of the lungs from air accumulating in the cavity of the pleura, he could not have survived.We may, therefore, look on the escape of air into the cellular membrane, external to the chest, as having been a source of safety-like the steam let off by the engineer, from an overcharged boiler.In the course of watching the case, we had to keep our minds directed to three distinct sources of difficult breathing: first, that which might depend on the patient's former disease of the chest, of the nature of which we had no exact information;secondly, that which might be the ordinary effect of several ribs having been broken at the same time; thirdly, that which might arise at any moment from the air that escaped at the wound becoming confined, and increasing in quantity within the cavity of the pleura, so as to compress and stop the breathing in one or both lungs.You will have observed that we applied the rib-roller at first, and immediately afterwards removed it; but again, when the
Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009
Authors: C R Simpson, N I Lone, K Kavanagh, L D Ritchie, C Robertson, Aziz Sheikh, J McMenamin
Journal: Eurosurveillance (2015)

Binary file ES_Abstracts_Final_ECDC.txt matches
Medical Department, United States Army. Internal Medicine in World War II. Vol. 2: Infectious Diseases
Authors: John H. Talbott
Journal: JAMA (1963)

Paul Havens, as editor for internal medicine in the series on the history of the Medical Department of the Army, has recruited a distinguished contributing staff in preparing the documentary treatise on infectious diseases. In this venture, he deserves full credit for one of the important chronicles in American medicine. World War II was the first major war for the US Army in which infection and contagion were less devastating than battle injuries. The discovery of the antimicrobial action of the sulfonamides in the 1930's and the penicillins shortly after was a determining factor. The antimalarials and, near the end of the war, streptomycin likewise were suppressive or curative agents of great practical significance. In World War I, there were more than 46,000 deaths from acute pulmonary diseases and measles. In World War II, in which the army was more than twice the size of the World War I army,
THIN–CAP FIBROATHEROMA CONCOMITANT WITH CALCIUM DEPOSITION IS A POWERFUL PREDICTOR OF PERIPROCEDURAL ENZYME ELEVATION DURING ELECTIVE PCI
Authors: Tomoya Ueda, Shiro Uemura, Yu Sugawara, Tsunenari Soeda, Makoto Watanabe, Yukiji Takeda, Hiroyuki Kawata, Yoshihiko Saito
Journal: Journal of the American College of Cardiology (2013)
THE CAUSE OF DEATH IN THIRTY CASES OF RHEUMATOID ARTHRITIS
Authors: EDWARD F. ROSENBERG
Journal: Annals of Internal Medicine (1943)

Article1 July 1943THE CAUSE OF DEATH IN THIRTY CASES OF RHEUMATOID ARTHRITIS(Abstract)EDWARD F. ROSENBERG, ARCHIE H. BAGGENSTOSS, PHILIP S. HENCHEDWARD F. ROSENBERGSearch for more papers by this author, ARCHIE H. BAGGENSTOSSSearch for more papers by this author, PHILIP S. HENCHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-1-114 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe have studied the cause of death in 30 cases of rheumatoid arthritis. This number represents all the cases of this condition in which necropsy has been performed at the Mayo Clinic in the past 25 years.In each case the arthritis had been progressive and had produced some degree of crippling. The articular changes were easily detected and included spindle shaped swellings of joints, atrophy of muscles, synovial thickening and effusions, and some degree of fibrous ankylosis. In a few early cases roentgenograms were negative, but in most of the cases the roentgenograms showed swellings of soft tissues, osteoporosis,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNiere bei Tumoren, Blutkrankheiten und ParaproteinämienAmyloidosis in Rheumatoid Arthritis: INVESTIGATED BY MEANS OF RECTAL BIOPSYRheumatoid aortitis with aortic regurgitationSYNDROMES OF RHEUMATOID ARTHRITISRheumatoid spondylitis with carditisReview of the Literature on Acute Rheumatism During the Years 1939-1945 1 July 1943Volume 19, Issue 1Page: 114-118KeywordsArthritisAtrophyInflammationMusclesOsteoporosisRheumatoid arthritisSoft tissues ePublished: 1 December 2008 Issue Published: 1 July 1943 PDF downloadLoading ...
HUMAN TEMPERATURE IN DISEASE.
Authors: NORMAN BRIDGE
Journal: JAMA (1900)

We are always seeking for symptoms that tell the exact nature of the diseases of the human body. If there were idiopathic signs the people would learn many of them, and hardly need doctors, except for the mysteries of treatment; and even these they would more or less master in time, as now they often think they have mastered them. The doctors are alert for the smallest hint of a new sign that can show without error the goings-on in the sick body. The treatment of disease troubles us rather less than the diagnosis; and we are usually more chagrined at our errors of diagnosis than at blunders of treatment. The temperature of the body in health is maintained at a given point, with slight fluctuations, in all climates and conditions; and it fluctuates peculiarly in disease, and probably with some approach to a typical manner. How these mutations may
Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death
Authors: Nese Imeryuz, Veysel Tahan, Abdullah Sonsuz, Fatih Eren, Suleyman Uraz, Meral Yuksel, Sertac Akpulat, Dervis Ozcelik, Goncagul Haklar, Cigdem Celikel, Erol Avsar, Nurdan Tozun
Journal: Journal of Hepatology (2007)
Abstract 875: Ovarian and uterine carcinosarcoma: A comparative analysis of prognostic variables and survival outcomes
Authors: Gunjal Garg, Jay P. Shah, Christopher Bryant, Sanjeev Kumar, Robert T. Morris
Journal: Cancer Research (2010)

Abstract Objective: Carcinosarcomas (malignant mixed mullerian tumor) of the female genital tract are rare tumors associated with poor outcome. Previous studies have demonstrated that even tumors of similar histology originating in organs that are in proximity may be biologically distinct entities by virtue of their occurrence through different molecular pathways. The objective of this study was to identify site specific differences in the clinical behavior and survival outcome of carcinosarcomas originating in female genital tract by comparing carcinosarcomas arising in the uterus and ovaries. Methods: Data on patients with uterine carcinosarcoma and ovarian carcinosarcoma were extracted from the Surveillance, Epidemiology, and End Results database between 1988 and 2005. Kaplan-Meier log rank and Cox proportional hazards models were used for survival analysis and to identify possible predictors for survival. Results: The identified cohort included 3,683 women, with 2,759 (75%) uterine carcinosarcomas and 924 (25%) ovarian carcinosarcomas. Uterine carcinosarcoma patients were older than patients with ovarian carcinosarcoma (median age 67.61 vs. 65.83 years, p&amp;lt;0.001). Women with uterine carcinosarcomas compared with ovarian carcinosarcoma were more often African American (17.3% versus 6%; P&amp;lt;0.001) and presented more often with early stage disease (Stage I/II 56.6% compared with 24.6%; P &amp;lt;0.001). Uterine compared to ovarian carcinosarcomas differed significantly with regards to the performance of salpingo-oopherectomy (96 % versus 99.4 %; P = 0.001), lymphadenectomy (62.6% versus 41.2%; P &amp;lt;0.001), and administration of radiotherapy (38.2% versus 4.8%; P &amp;lt;0.001). No difference was found in survival between patients with uterine and ovarian carcinosarcoma on stage- stratified Kaplan- Meier survival analysis or multivariate analysis using Cox model. Although, age (p&amp;lt;0.001), race (p&amp;lt;0.001), marital status (p&amp;lt;0.001), stage (p&amp;lt;0.001), lymphadenectomy (p&amp;lt;0.001), and radiation (p=0.005) were all significant prognostic factors in uterine carcinosarcoma, only age (p=0.001), stage (p&amp;lt;0.001), and lymphadenectomy(p&amp;lt;0.001) reached statistical significance in ovarian carcinosarcoma on multivariate analysis. Conclusion: Ovarian carcinosarcomas present at a more advanced stage and have a comparable prognosis at each stage with uterine carcinosarcomas. Improved survival observed in lymphadenectomy group argues in favor of routinely performing lymph node dissection in patients with uterine and ovarian carcinosarcoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 875.
EXPERIMENTALLY INDUCED ACUTE ORAL CANDIDOSIS IN THE RAT
Authors: J. H. JONES, D. Adams
Journal: British Journal of Dermatology (1970)

SUMMARY.– The Wistar rat has been shown to be a suitable experimental animal in a model for the study of oral candidosis. The micro-organisms penetrated the stratum corneum of the tongue and buccal mucosa producing lesions resembling those in acute oral candidosis in humans. Salivary flow as varied in this experiment does not appear to be important in the genesis of this infection.
PET Imaging of Cerebral and Pulmonary Nocardia Infection
Authors: Neil B. Mascarenhas, Dorothy Lam, Garrett R. Lynch, Ronald E. Fisher
Journal: Clinical Nuclear Medicine (2006)

We report the case of a 69-year-old man who was suspected to have lung cancer with a single metastasis to the brain. Initial workup for neurologic and pulmonary symptoms demonstrated a ring-enhancing lesion in his right frontal lobe on MRI and a lung mass on CT. An F-18 fluorodeoxyglucose positron emission tomography (FDG PET) scan demonstrated marked glucose hypermetabolism in the lung and brain lesions with maximal standard uptake values (SUV) in both lesions of approximately 11. Biopsy of the brain mass revealed an abscess and cultures grew Nocardia. He was treated for nocardiosis, and a repeat CT of the chest in 2 months and MRI of the brain in 5 months showed nearly complete resolution of the lesions. Currently, there are few reported cases of PET evaluation of brain abscesses, particularly Nocardia. We discuss the appearance of brain infections on FDG PET scans in immunocompetent and immunocompromised patients.
Sins of the fathers
Authors: L. Farrell
Journal: BMJ (1995)

I was raised as a Catholic; so although I'm now searching for my own truths, and although I see more and more the pernicious effects of organised religion, I do retain some affection for the church of my forefathers, and it gives me no satisfaction to observe the scandal which is sweeping Ireland.

New reports of child sex abuse by priests are occurring almost daily. We shouldn't really be surprised; people wishing for that kind of life are very different from the rest of us to begin with. Their training and lifestyle exacerbate this difference, and finally, to complete the fatal mixture, they are placed in positions of …
Immunohemolytic Anemia Due to Antipenicillin Antibodies
Authors: Marilynne A. Swanson, Devendrathan Chanmougan, Robert S. Schwartz
Journal: New England Journal of Medicine (1966)

HEMOLYTIC anemia with a positive direct antiglobulin test is generally considered to be the result of autoimmunization. In a few cases, however, sensitization to drugs has been demonstrated to be the underlying mechanism of this disorder. Stibophen (Fuadin)1 and quinidine,2 for example, have been identified as haptens that can result in immunohemolytic anemia. Penicillin hypersensitivity has also been associated with hemolytic anemia, but the role of penicillin antibodies in this disease has not been definitely established.3 4 5 The purpose of this report is to describe a case of immunohemolytic anemia in which circulating antipenicillin antibodies were directly involved.MethodsRoutine hematologic . . .
Polymorphism of tandem repeat in promoter of 5‐lipoxygenase in ASA‐intolerant asthma: a positive association with airway hyperresponsiveness
Authors: S.‐H. Kim, J.‐S. Bae, C.‐H. Suh, D.‐H. Nahm, J. W. Holloway, H.‐S. Park
Journal: Allergy (2005)

5-Lipooxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) are known as key enzymes in cysteinyl-leukotriene (cys-LT) production, critical mediators in aspirin acetylsalicyclic acid (ASA)-intolerant asthma (AIA). To date, studies of the promoter region of ALOX5 gene has revealed the potential influence of a variable number of tandem repeats of a Sp1- and Egr1-binding motif, on the transcription rate.To understand the pathological process that arises from cys-LT overproduction in AIA, we genotyped ALOX5 Sp1 and ALOX5AP poly(A) repeat promoter polymorphism by fluorescent-based capillary electrophoresis in the Korean population.No significant differences in allele and genotype frequencies of the ALOX5 and ALOX5AP promoter polymorphisms were observed between the three groups. However, there was a strong association of the ALOX5 Sp1 repeat polymorphism with airway hyperresponsiveness (AHR; PC20 methacholine); AIA patients carrying a mutant allele (n > 5 or n < 5 repeats) showed increased AHR compared to AIA patients with wild-type genotype (P=0.003).Although the alleles of the ALOX5 and ALOX5AP promoter cannot be considered as a prominent risk factor in the development of AIA, the genetic variant of tandem repeat (GGGCGG; Sp1-binding motif) in ALOX5 promoter is associated with the severity of airway hyperresponsiveness in AIA patients.
Optimizing technique in elliptical excisional surgery: some pearls for practice
Authors: W. Hussain, N.J. Mortimer, P.J.M. Salmon
Journal: British Journal of Dermatology (2009)

Journal Article Optimizing technique in elliptical excisional surgery: some pearls for practice Get access W. Hussain, W. Hussain Dermatological Surgical Unit, Skin Centre Specialist Medical Facility, Cameron Road, Tauranga, New Zealand E‐mail: dr_w_hussain@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar N.J. Mortimer, N.J. Mortimer Dermatological Surgical Unit, Skin Centre Specialist Medical Facility, Cameron Road, Tauranga, New Zealand E‐mail: dr_w_hussain@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar P.J.M. Salmon P.J.M. Salmon Dermatological Surgical Unit, Skin Centre Specialist Medical Facility, Cameron Road, Tauranga, New Zealand E‐mail: dr_w_hussain@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 161, Issue 3, 1 September 2009, Pages 697–698, https://doi.org/10.1111/j.1365-2133.2009.09312.x Published: 01 September 2009
Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects
Authors: Joon-Keun Park, Dominik N. Müller, Eero M.A. Mervaala, Ralf Dechend, Anette Fiebeler, Folke Schmidt, Markus Bieringer, Olaf Schäfer, Carsten Lindschau, Wolfgang Schneider, Detlev Ganten, Friedrich C. Luft, Hermann Haller
Journal: Kidney International (2000)
The Waning Effect of Postmenopausal Estrogen Therapy on Osteoporosis
Authors: Bruce Ettinger, Deborah Grady
Journal: New England Journal of Medicine (1993)

Almost all physicians and their patients believe that estrogen treatment can prevent osteoporosis. Evidence from the Framingham Study reported in this issue of the Journal supports this hypothesis1. In women less than 75 years old who had received long-term estrogen therapy, bone mineral density was higher than in women who had never taken estrogen. In women more than 75 years old, however, there was little difference in bone density between women who had taken estrogen and those who had not. How can we reconcile these results with what is known about the effect of estrogen on the risk of . . .