Effects of Aspirin on Glomerular Filtration Rate in Normal Humans
Authors: RICHARD S. MUTHER
Journal: Annals of Internal Medicine (1980)

Brief Reports1 March 1980Effects of Aspirin on Glomerular Filtration Rate in Normal HumansRICHARD S. MUTHER, M.D., WILLIAM M. BENNETT, M.D.RICHARD S. MUTHER, M.D., WILLIAM M. BENNETT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-386 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAspirin recently has been reported to produce clinically significant declines in renal blood flow and glomerular filtration rate (1-5). Aspirin-induced inhibition of renal prostaglandin synthesis is thought to be responsible for this effect (5, 6). The most dramatic changes in renal function have been observed in patients with underlying renal diseases, although similar changes have been noted in normal humans (1, 3).The clinical significance of these changes has been difficult to interpret because previous measurements of the glomerular filtration rate have shown some variability (7) and the study conditions of the subjects have not been precisely defined. We therefore...References1. ROBERT M, FILLASTRE J, BERGER H, and MALANDAIN H. Effect of intravenous infusion of acetylsalicylic acid on renal function. Br Med J. 1972; 2:466-7. Letter. CrossrefMedlineGoogle Scholar2. BURRY H, DIEPPE P, BRESNIHAN F, and BROWN C. Salicylates and renal function in rheumatoid arthritis. Br Med J. 1976; 1:613-5. CrossrefMedlineGoogle Scholar3. KIMBERLY R and PLOTZ P. Aspirin-induced depression of renal function. N Engl J Med. 1977; 296:418-24. CrossrefMedlineGoogle Scholar4. BERG K. Acute effects of acetylsalicylic acid in patients with chronic renal insufficiency. Eur J Clin Pharmacol. 1977;11:111-6. CrossrefMedlineGoogle Scholar5. KIMBERLY R, GILL J, BOWDEN R, KEISER H, and PLOTZ P. Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus. Ann Intern Med. 1978;89:336-41. LinkGoogle Scholar6. KIMBERLY R. Renal prostaglandins in ischemic lupus erythematosus. Lancet. 1978;2:553-5. CrossrefMedlineGoogle Scholar7. BURRY H and DIEPPE P. Apparent reduction of endogenous creatinine clearance by salicylate treatment. Br Med J. 1976; 2:16-7. CrossrefMedlineGoogle Scholar8. BENNETT W and PORTER G. Endogenous creatinine clearance as a clinical measure of glomerular filtration rate. Br Med J. 1971;4:84-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD S. MUTHER, M.D.; WILLIAM M. BENNETT, M.D.Affiliations: Department of Medicine University of Oregon Health Sciences Center Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxic NephropathiesTreatment of pain in patients with renal insufficiency: The World Health Organization three-step ladder adaptedClinical Consequences of Nonnarcotic Analgesic UseDoes aspirin cause acute or chronic renal failure in experimental animals and in humans?Ketorolac Induced Acute Renal Failure Following a Single DoseIndomethacin-induced renal dysfunction in patients with well-compensated cirrhosisRenal Blood FlowRenal Prostaglandins and Other EicosanoidsRenal response to Indomethacin in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathyAspirin alters methotrexate disposition in rheumatoid arthritis patientsPrediction of organ system toxicity with antirheumatic drug therapyRenal effects of angiotensin-converting enzyme inhibition in congestive heart failurePharmacologic Treatment of Chronic PainEffect of an Analgesic Dose of Aspirin on Electrolyte Disposition in Healthy SubjectsArachidonic acid metabolism in renal diseaseReversible Acute Decrease in Renal Function by NSAIDs in CirrhosisClinical pharmacology of non-steroidal anti-inflammatory drugsInterstitial nephropathies and pyelonephritis in the agedInteraction of nonsteroidal anti-inflammatory drugs with antihypertensive and diuretic agents: Control of vascular reactivity by endogenous prostanoidsEffects of nonsteroidal anti-inflammatory drugs in healthy subjectsRenal Effects of Nonsteroidal Antiinflammatory DrugsNon-steroidal and Analgesic Therapy in the ElderlyRenal hemodynamic effects of therapeutic plasma levels of sulindac sulfide during hemorrhageProstaglandins and nonsteroidal anti-inflammatory drugs: Effects on renal hemodynamicsDrug-drug and drug-disease interactions with nonsteroidal anti-inflammatory drugsPharmaco—Epidemiological Considerations in Patients with Arthritis and Vascular Disease of the KidneyEffects of prostaglandin synthesis inhibitors on the renin-angiotensin system and renal function.Statement on the Release of Ibuprofen as an Over-the-Counter MedicineEffects of ibuprofen, naproxen, and sulindac on prostaglandins in menRenal Insufficiency Associated With Nonsteroidal Anti-inflammatory AgentsRenal Syndromes Associated with Nonsteroidal Antiinflammatory DrugsNephrotoxicity of Nonsteroidal Anti-Inflammatory DrugsAspirin and renal diseaseOrthopedic surgeryRenal ProstaglandinsTubular Actions of Arachidonic Acid MetabolitesNephrotoxicity of Nonsteroidal Anti-Inflammatory AgentsUrinary Excretion of Prostaglandin F2α and 6-Keto-Prostaglandin F1αa during Volume Expansion in Patients with GlomerulonephritisAngiotensin-induced sodium excretion patterns in cirrhosis: Role of renal prostaglandinsAspirin-Induced Depression of Glomerular Filtration Rate in Normal Humans: Role of Sodium BalanceRICHARD S. MUTHER, M.D., DONALD M. POTTER, M.D., WILLIAM M. BENNETT, M.D. 1 March 1980Volume 92, Issue 3 Page: 386-387 Keywords Aspirin Glomerular filtration rate Prostaglandin Renal circulation Renal diseases ePublished: 1 December 2008 Issue Published: 1 March 1980 PDF downloadLoading ...