tbuckley/cabot-search huggingface dataset:
(14) Epidermolysis bullosa acquisita
Authors: Robert Tan
Journal: British Journal of Dermatology (1977)

Journal Article (14) Epidermolysis bullosa acquisita Get access Robert Tan Robert Tan Royal United Hospital, Bath Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Pages 46–48, https://doi.org/10.1111/j.1365-2133.1977.tb14322.x Published: 01 December 1977
Acute Myocardial Infarction: Prognosis after Recovery
Authors: MYRON H. LURIA
Journal: Annals of Internal Medicine (1976)

A prognostic index for 2-year survival after recovery from acute myocardial infarction was constructed from variables obtained during its course. One hundred ten of 143 patients survived 2 years, and 27 of 33 patients died of cardiac-related causes. Univariate analysis showed that 12 variables were significantly different between the surviving and nonsurviving groups. Discriminant analysis indicated five variables with meaningful predictive value to be included in a prognostic index: admission systolic blood pressure; highest blood urea nitrogen level in the cardiac care unit; atrial arrhythmias in the cardiac care unit; angina pectoris for more than 3 months or a previous myocardial infarction; and more than one ventricular ectopic beat per hour recorded on a dynamic electrocardiogram during the 17th to 24th hospital day. The prognostic index emphasizes the importance of extensive myocardial impairment and provides a means for identifying patients at risk of early mortality.
Effect of chronic renal failure on the level of albumin messenger RNA
Authors: Atsushi Yamauchi, Enyu Imai, Tamio Noguchi, Takehiko Tanaka, Shigeo Yamamoto, Hiroshi Mikami, Yoshifumi Fukuhara, Masamitsu Fujii, Yoshimasa Orita, Takenobu Kamada
Journal: Metabolism (1989)
Cela n'etait pas une couverture
Authors: John R. Hughes
Journal: JAMA (1989)

To  Editor.—  The cover of your most recent issue on smoking— La trahison des images (Ceci n'est pas une pipe) —is ostensibly a painting of a tobacco-connected product. Yet your cover discussant, Dr Southgate, 1 states  painting is intended to illustrate how an object can have multiple realities; eg,  painting is a pipe, is a picture of a pipe, is a symbol representing all pipes, etc. Dr Southgate suggests the viewer must... distinguish among  various realities and perhaps even begin to wonder what reality is.  I believe this cover is especially appropriate as tobacco has several realities in our society. The Surgeon General 2 and  American Psychiatric Association 3 state that tobacco is a drug of dependence. The majority of  lay public,  Food and Drug Association, and  tobacco industry state tobacco is not a drug. The Department of Agriculture states tobacco is
WHO fills three key posts
Authors: A. Mach
Journal: BMJ (1998)

The World Health Organisation (WHO) has announced three key appointments: the project managers for the two top priority cabinet projects--the Tobacco Free initiative and the Roll Back Malaria project--and the director of public relations.

“These are the first three director level posts that have been publicly advertised,” said the organisation's senior policy adviser, Denis Aitken “This marks a break with the past,” he said, “opening up the WHO to external candidates, especially qualified women.” Of the three appointments, two were external, and one of these was a woman.

Derek Yach, a South African epidemiologist, has been acting project manager of the Tobacco Free initiative since July and has now been confirmed by the WHO's director general for a three …
UK patients' reports of adverse reactions are more detailed than doctors'
Authors: S. Mayor
Journal: BMJ (2011)

Patients’ reports of adverse reactions to drugs are richer in detail and better at describing the impact of suspected side effects on their daily lives than information provided by healthcare professionals, shows a UK study.

Researchers assessed the effect of inviting patients or their representatives to report to the United Kingdom’s yellow card scheme for reporting adverse reactions. Healthcare professionals have reported side effects to this voluntary scheme since 1964, but it was opened up to patients in October 2005. Yellow card reports are submitted to the Medicines and Healthcare Products Regulatory Agency by post or telephone or through the internet.

The study compared 26 129 yellow card reports made by patients (20% …
Role of AT-1 receptor in regulation of vascular MCP-1, IL-6, PAI-1, MAP kinase, and matrix expressions in obesity
Authors: Nosratola D. Vaziri, Zhong-Gao Xu, Ashkan Shahkarami, Kevin T. Huang, Bernardo Rodruguez-Iturbe, R. Natarajan
Journal: Kidney International (2005)
Defective spectrin integrity and neonatal thrombosis in the first mouse model for severe hereditary elliptocytosis
Authors: Nancy J. Wandersee, Amanda N. Roesch, Nancy R. Hamblen, Joost de Moes, Martin A. van der Valk, Roderick T. Bronson, J. Aura Gimm, Narla Mohandas, Peter Demant, Jane E. Barker
Journal: Blood (2001)
Intermediate-term effectiveness of balloon valvuloplasty for congenital aortic stenosis. A prospective follow-up study.
Authors: B K O'Connor, R H Beekman, A P Rocchini, A Rosenthal
Journal: Circulation (1991)

BACKGROUND Percutaneous balloon valvuloplasty has proven to be acutely effective in the treatment of congenital valvar aortic stenosis; however, the intermediate- and long-term effectiveness of the procedure remain to be documented. METHODS AND RESULTS To assess the intermediate-term effectiveness of balloon valvuloplasty, repeat catheterization was performed in 27 of 30 children 1.7 +/- 0.1 years after balloon valvuloplasty for congenital aortic stenosis (AS). In 33 children the peak AS gradient was reduced acutely by 55% from 77 +/- 4 to 35 +/- 3 mm Hg (p less than 0.001), and left ventricular systolic pressure was reduced from 176 +/- 4 to 138 +/- 4 mm Hg (p less than 0.001). Despite a technically adequate valvuloplasty procedure, three patients had inadequate relief of obstruction and required complex surgical intervention. Twenty-seven of the 30 patients available for late reevaluation (90%) enrolled in the follow-up study. The peak AS gradient remained significantly reduced compared with that present before valvuloplasty (29 +/- 3 versus 77 +/- 4 mm Hg, p less than 0.001). Furthermore, there was no difference in peak AS gradient at follow-up compared with that immediately after valvuloplasty. The greatest increase in gradient at reevaluation was 14 mm Hg. Twenty of 27 patients (74%) had no change in the degree of aortic insufficiency at follow-up compared with that present before valvuloplasty. At follow-up, 16 patients had no aortic insufficiency at all, and only two had moderate-to-severe (3-4+) insufficiency. Femoral artery injury was documented in four patients, three of whom were under 12 months of age at valvuloplasty. CONCLUSIONS Balloon aortic valvuloplasty provides safe and effective intermediate-term gradient relief without early restenosis in children and adolescents with congenital AS.
REVERSIBLE CHANGES IN THE SUSCEPTIBILITY OF MICE TO BACTERIAL INFECTIONS
Authors: René J. Dubos, Russell W. Schaedler
Journal: The Journal of Experimental Medicine (1956)

MICE WERE INJECTED INTRAPERITONEALLY WITH ONE OF THE FOLLOWING BACTERIAL PRODUCTS HAVING ENDOTOXIN ACTIVITY: pertussis vaccine, a suspension of heat-killed cells of Klebsiella pneumoniae (type C), or a purified lipopolysaccharide prepared from cultures of Salmonella typhosa. Following treatment with either one of these materials, the animals were infected intravenously with virulent cultures of coagulase-positive staphylococci, with bovine tubercle bacilli, or Friedländer bacilli. The effect of treatment with endotoxin materials on resistance to Friedländer bacilli, staphylococci, or tubercle bacilli was estimated by observing the mortality rates in infected animals, and by determining quantitatively the numbers of living bacteria in the organs at different periods of time after infection. It was found that mice receiving the infective dose of virulent culture a few hours after treatment with the endotoxin material, were usually more susceptible to infection than were untreated animals. In contrast, mice infected at a later period proved far more resistant to infection than did untreated animals. The duration of the negative and of the positive phase of resistance was affected by the amount of endotoxin injected. Marked increase in resistance of mice to infection with staphylococci or tubercle bacilli was still evident several weeks after treatment with pertussis vaccine or with purified lipopolysaccharide extracted from typhoid bacilli.
Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease
Authors: Torgun Wæhre, Jan K Damås, Lars Gullestad, Are M Holm, Terje R Pedersen, Kjell E Arnesen, Harald Torsvik, Stig S Frøland, Anne G Semb, P.ål Aukrust
Journal: Journal of the American College of Cardiology (2003)
Pleurisy and pulmonary granulomas after treatment with acebutolol.
Authors: G M Wood, R P Bolton, M F Muers, M S Losowsky
Journal: BMJ (1982)

clinical lecturer in surgery Pleurisy and pulmonary granulomas after treatment with acebutolol Many patients currently take beta-blockers to control hypertension or angina and such medication is often continued for years.Side effects are uncommon but reports of ocular, cutaneous, and serosal damage led to the withdrawal of the cardioselective beta-blocker practolol from long-term use.We report a case in which treatment with acebutolol was followed by recurrent attacks of pleurisy neces- sitating withdrawal of the drug. Case report
Automated Data Processing and Computer Analysis in Renal Transplantation
Authors: Keith Reemtsma
Journal: JAMA (1966)

Renal transplantation offers unique opportunities in the development of automated methods of data processing. Various groups working in renal transplantation use similar methods in selection, evaluation, and treatment of cases, thereby simplifying development of standard forms for data reporting. Furthermore, the large amount of data accumulated in these cases is difficult to analyze by standard methods. Full and prompt sharing of research information is a long-recognized and widely accepted goal in the scientific community. Complexities of biomedical research and limitations of communications, however, often preclude such sharing. By traditional methods, each investigator collects data, interprets results, and presents this information if, when, and how he chooses. A delay between accumulation of data and publication or presentation thus is inevitable. In some areas of medical research these delays are relatively unimportant or even desirable, as is the case, for example, when results are assessed in such terms as 5-year or 20-year
Psychosomatic Interaction between Mother and Infant during Breast Feeding
Authors: T.M. Tamminen, R.K. Salmelin
Journal: Psychotherapy and Psychosomatics (1991)

Within the context of a major research project on the impact of mother's depression on breast feeding, this study presents a qualitative analysis of mother-infant interaction during a single breast feeding situation. From the holistic perspective there emerged five central themes of interaction, which all displayed a different purpose. Mothers had quite often difficulties in psychosomatic interaction during a phase of hungry eating. More detailed analysis revealed some interesting differences between the depressed and nondepressed mothers.
Cell therapy generates a favourable chemokine gradient for stem cell recruitment into the infarcted heart in rabbits
Authors: Bai‐Chin Lee, Hsiu‐Ching Hsu, Wen‐Yih I. Tseng, Ching‐Yi Chen, Hung‐Ju Lin, Yi‐Lwun Ho, Ming‐Jai Su, Ming‐Fong Chen
Journal: European Journal of Heart Failure (2009)
S121 Assessment of interlobarcollateral ventilation prior to endobronchial valves treatment for severe emphysema
Authors: Sk Banerjee, J Babar, A Balan, R Mahadeva
Journal: Thorax (2013)

<h3></h3> Bronchoscopic lung volume reduction (BVLR) with one-way endobronchial valves are employed to reduce hyperinflation to improve symptoms and lung function. The clinical benefits of Zephyr (PulmonX) valves in achieving target lobe volume reduction are most marked in those without collateral ventilation (CV) between ipsilateral non-target and target lobes. The presence of CV can be assessed by visual assessment of fissure integrity on CT scan and by measurement of flow and resistance following balloon catheter occlusion of the target lobe bronchus (Chartis; PulmonX). We have compared these two techniques for assessing collateral ventilation in patients with severe emphysema referred for EBV treatment. Two respiratory radiologists reviewed the CT images in 19 consecutive patients. Fissure integrity was classified as complete, incomplete minor defect, incomplete major defect. Chartis assessment for CV status was performed on potential target lobes in the same patients, and results compared for the two methods. There was 57.9% (11/19), 63.2% (12/19) and 78.9% (15/19) agreement between radiologists on fissure analysis of the right horizontal (RH), right oblique (RO) and left oblique (LO) fissures (Table 1). In 11 patients with no collateral ventilation on Chartis evaluation to the target lobe; Radiologist 1 reported 9 complete and 2 with incomplete minor defects compared to Radiologist 2; 10 complete and one with incomplete major defect. In 8 found to be CV positive by Chartis, radiologist 1; 3 complete, 3 incomplete major and 2 incomplete minor defects, and radiologist 2; 4 complete, 2 incomplete major and 2 incomplete minor defects. In conclusion, there was inter-observer difference in reporting fissure integrity particularly for right sided fissures, with better agreement for left oblique fissure. However, when experienced chest radiologists scored fissures as complete, there was a high correlation with CV negative status by Chartis. If radiologists scored fissures as incomplete major only one case was found to be CV negative whilst 2 CV negative cases were incomplete minor. This data indicates that visual assessment of fissure integrity by experienced respiratory radiologists can be used as a screening tool to determine appropriateness for subsequent Chartis EBV assessment.
A CASE OF COR BOVINUM AND HORSE-SHOE KIDNEY—NECROPSY.
Authors: A. M. BEAL
Journal: JAMA (1896)

On Jan. 3, 1896, Dr. B. F. Hall and the writer, assisted by Drs. W. K. Sloan and G. G. Craig, conducted a necropsy on the remains of O. N. R., an American, aged 43 yrs. 5 mos., which presented excellent specimens of the so-called cor bovinum and the horse-shoe kidney. The heart was found to weigh forty ounces and measured eight inches in length, five inches in breadth, four inches in thickness and fifteen inches in its greatest circumference. The hypertrophy was due mainly to an increase in the muscular tissue of the walls of the ventricles, and no indications of degeneration of this tissue could be found. The hypertrophy was so nearly uniform in the walls of the two ventricles as to preserve quite completely the symmetrical appearance of the organ. The right ventricular wall was half an inch in the greatest thickness; the left, one and one-fourth
Combination electro-gene therapy using herpes virus thymidine kinase and interleukin-12 expression plasmids is highly efficient against murine carcinomas in vivo
Authors: Tomoaki Goto, Toru Nishi, Osamu Kobayashi, Takahiko Tamura, Sukhendu B. Dev, Hideo Takeshima, Masato Kochi, Jun-ichi Kuratsu, Tsuneaki Sakata, Yukitaka Ushio
Journal: Molecular Therapy (2004)

We report the use of plasmid DNA-mediated combination gene therapy for tumor-bearing mice using in vivo electroporation, also called electro-gene therapy (EGT), that resulted in uncomplicated and complete cures in more than 90% of the mice. Subcutaneously inoculated CT26 tumors in syngeneic BALB/c mice were subjected to repeated EGT treatments consisting of intratumoral co-injection of naked plasmids encoding the cytokine interleukin-12 (IL-12) (p35 and p40 subunits) and the suicide gene herpes simplex virus thymidine kinase (HSV-tk), followed by in vivo electroporation. The early anti-tumor effect was always stronger, and the rate of cure, as seen in the long-term follow-up, was always greater in the groups treated with combination EGT than in those treated with IL-12 or HSV-tk EGT alone. Systemic levels of IL-12 and IFN-γ increased in both combination and IL-12-alone EGT-treated groups. Moreover, combination EGT for established subcutaneous tumors strongly reduced hematogenous lung metastases and increased survival time when live CT26 tumor cells were injected through the tail vein. Limited experiments on C57/B16 mice with murine melanoma also showed very similar trends. These results suggest that this simple and safe method of plasmid-mediated combination EGT may provide a potentially effective gene therapy for cancer.
α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion
Authors: Shangang Zhao, Yves Mugabo, Jose Iglesias, Li Xie, Viviane Delghingaro-Augusto, Roxane Lussier, Marie-Line Peyot, Erik Joly, Bouchra Taïb, Matthew A. Davis, J. Mark Brown, Abdelkarim Abousalham, Herbert Gaisano, S.R. Murthy Madiraju, Marc Prentki
Journal: Cell Metabolism (2014)
A Dual-Energy X-ray Absorptiometry Scan
Authors: Lorna A. Lynn
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Plenty of fuel for Agent Orange dispute
Authors: Phil Gunby
Journal: JAMA (1979)

More studies are under way or planned in the Agent Orange controversy. The latest study will be conducted by the US Air Force beginning in October and will focus on an intensively exposed population: military personnel who sprayed the defoliant on Vietnam's jungles from the air for more than eight years so as to deny cover and food crops to the enemy. Agent Orange contains 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), a synthetic growth-regulating compound that has been used as a herbicide since 1944 in the United States and elsewhere because it can kill broadleaf plants by overstimulating their phototropic response. The Environmental Protection Agency (EPA) banned most herbicidal uses in this country five months ago, citing "a high miscarriage rate [130 spontaneous abortions within three months] following the spraying of 2,4,5-T in forests around Alsea, Ore." There continue to be widely varying opinions about the Alsea Basin data and about other possible
Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma.
Authors: M Cravo, R Pinto, P Fidalgo, P Chaves, L Gloria, C Nobre-Leitao, F Costa Mira
Journal: Gut (1996)

BACKGROUND: Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS: The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS: Gastric specimens were obtained from 49 patients and histologically classified as: normal 10, superficial gastritis 14, chronic atrophic gastritis with intestinal metaplasia 15, and intestinal type of gastric carcinoma 10. Global DNA methylation was assessed by incubating DNA with (3H)-S-adenosylmethionine and Sss1 methylase. A higher incorporation of (3H) methyl groups reflects a lower degree of intrinsic methylation. RESULTS: A graduated increase in (3H) methyl group incorporation into DNA was found over the range extending from normal gastric mucosa, to superficial gastritis and to chronic atrophic gastritis (136,556 (24,085) v 235,725 (38,636) v 400,998 (26,747 dpm/micrograms/DNA respectively; p = 0.0002). No further increase was found in specimens from patients with carcinoma. No differences were found between extent of DNA methylation in neoplastic or non-neoplastic mucosa from patients with gastric carcinoma. Hypomethylation of DNA increased substantially with severe atrophy (p = 0.01) or with type III intestinal metaplasia (p = 0.15). CONCLUSIONS: Global DNA hypomethylation occurs in the early stages of gastric carcinogenesis, and it may be a novel biomarker of gastric neoplasia, useful in monitoring the response to chemopreventive agents.
Scuba Tank Capacity
Authors: Lloyd F. Walk
Journal: JAMA (1973)

To the Editor.—  In the Nov 6, 1972 issue ofThe Journal, Dr. Ronald M. Sommer submits a letter regarding the capacity of a scuba diving tank (222:705, 1972). It is apparent from the information published that Dr. Sommer did not do his homework on the physics of diving and the gas laws involved. Had he done so, he would have found that his 70-cu ft of air single tank, which he states would last 70 minutes at sea level (that presumes a use rate of 1 cu ft/min) would last 35 minutes at 33 feet, 21 minutes at 36 feet, and 17.5 minutes at 99 feet. Dr. Sommer had the right idea but his mathematical progression was wrong.
Danazol Therapy for Autoimmune Hemolytic Anemia
Authors: Yeon S. Ahn, William J. Harrington, Ravindra Mylvaganam, Jorge Ayub, Lorraine M. Pall
Journal: Annals of Internal Medicine (1985)

We evaluated the use of danazol in 15 patients with autoimmune hemolytic anemia of the warm antibody type. Danazol, 600 to 800 mg/d, was added to previous regimens or given initially in conjunction with high-dose prednisone treatment. Twelve patients with autoimmune hemolytic anemia associated with nonmalignant disorders or idiopathic autoimmune hemolytic anemia and 1 of 3 patients with underlying neoplasms showed a rise in hematocrit within 1 to 3 weeks. Thereafter, glucocorticoid doses were tapered to a minimum requirement or stopped. Once remission was sustained, the dose of danazol was reduced to 200 to 400 mg/d. Although levels of erythrocyte-bound IgG antibody and C3 decreased with therapy, only the decrease in C3 was statistically significant (p less than 0.05) in this limited study. Danazol was effective regardless of the severity of the disorder and success or failure of previous treatments. Danazol is valuable in the treatment of autoimmune hemolytic anemia and may be better suited than glucocorticoids for long-term management.