Resorcinol-Induced Hypothyroidism in a Patient on Chronic Hemodialysis
Authors: M. J. KATIN
Journal: Annals of Internal Medicine (1977)

Letters1 April 1977Resorcinol-Induced Hypothyroidism in a Patient on Chronic HemodialysisM. J. KATIN, M.D., B. P. TEEHAN, M.D., F.A.C.P., M. H. SIGLER, M.D., F.A.C.P., C. R. SCHLEIFER, M.D., G. S. GILGORE, M.D.M. J. KATIN, M.D.Search for more papers by this author, B. P. TEEHAN, M.D., F.A.C.P.Search for more papers by this author, M. H. SIGLER, M.D., F.A.C.P.Search for more papers by this author, C. R. SCHLEIFER, M.D.Search for more papers by this author, G. S. GILGORE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-4-447 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn increased frequency of thyroid function abnormalities has been noted in patients on hemodialysis (1). Several causes have been suggested, including decreased elimination of goitrogenic substances, iodine deficiency, iodine excess malnutrition, the presence of fluoride in the dialysate, impaired conversion of thyroxine (T4) to triiodothyronine (T3), and direct interference of the uremic state on thyroid function. We have observed hypothyroidism in a patient on chronic hemodialysis who applied extraordinarily large amounts of a commonly used resorcinol-containing skin cream because of pruritus. The prompt correction of the hypothyroid state with withdrawal of the skin preparation strongly suggests that it acted as...References1. RAMÍREZJUBIZGUTCH GWC: Thyroid abnormalities in renal failure. Ann Intern Med 79:500-504, 1973 LinkGoogle Scholar2. BABBSTRANDUVELLI AMD: Quantitative description of dialysis treatment: a dialysis index. Kidney Int 7(Suppl 2):23-29, 1975 Google Scholar3. BULLFRASER GR: Myxoedema from resorcinol ointment applied to leg ulcers. Lancet 258:851-855, 1950 CrossrefGoogle Scholar4. FAWCETTKIRKWOOD DS: The mechanism of the antithyroid action of iodide ion and of the "aromatic" thyroid inhibitors. J Biol Chem 204:787-796, 1953 CrossrefMedlineGoogle Scholar5. ROSENBERG I: The antithyroid activity of some compounds that inhibit peroxidase. Science 116:503-505, 1952 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. J. KATIN, M.D.; B. P. TEEHAN, M.D., F.A.C.P.; M. H. SIGLER, M.D., F.A.C.P.; C. R. SCHLEIFER, M.D.; G. S. GILGORE, M.D.Affiliations: Department of Nephrology Lankenau Hospital Philadelphia, PA 19151 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA comparison of potency differences among thyroid peroxidase (TPO) inhibitors to induce developmental toxicity and other thyroid gland-linked toxicities in humans and ratsHazardous Chemical Substances:Resorcin [MAK Value Documentation in German language, 2002]Resorcinol [MAK Value Documentation, 2003]Scientific Opinion on the use of Resorcinol as a food additiveToxicology Review and Risk Assessment of Resorcinol: Thyroid EffectsApproaches to the assessment of toxicity data with endpoints related to endocrine disruptionDrugs used on the skin 1 April 1977Volume 86, Issue 4Page: 447-449KeywordsHypothyroidismMalnutritionPruritusThyroidThyroxineTriiodothyronine ePublished: 1 December 2008 Issue Published: 1 April 1977 PDF downloadLoading ...