tbuckley/cabot-search huggingface dataset:
CAN TRANSTHORACIC DOPPLER ECHOCARDIOGRAPHY BE USED TO DETECT CORONARY SLOW FLOW PHENOMENON?
Authors: Shao-Ping Nie, Li-Li Geng, Xiao Wang, Xiao-Shan Zhang, Ya Yang, Edmundo P. LOPES LAO, Jun Li, Yan Qiao, Xin-Min Liu, Tai-Yang Luo, Jian-Zeng Dong, Xiao-Hui Liu, Chang-Sheng Ma
Journal: Journal of the American College of Cardiology (2011)
CHARACTERISTIC FEATURES OF SLEEP DISORDERED BREATHING IN THE CONVALESCENT PHASE OF AORTIC DISSECTION: COMPARATIVE ANALYSIS WITH STABLE CORONARY ARTERY DISEASE
Authors: Toru Inami, Yoshihiko Seino, Nakahisa Kimata, Masanori Yamamoto, Kazunori Tomita, Akihiro Shirakabe, Ryo Munakata, Daisuke Murakami, Takuro Shinada, Masamichi Takano, Takayoshi Ohba, Chikao Ibuki, Noritake Hata, Kyoichi Mizuno
Journal: Journal of the American College of Cardiology (2013)
796. In Vivo Elimination of Human Leukaemia Cells by WT1 Specific TCR Transduced T Cells
Authors: Shao-An Xue, Liquan Gao, Daniel Hart, Waseem Qasim, Adrian Thrasher, Jane Apperley, Wolfgang Uckert, Emma Morris, Hans Stauss
Journal: Molecular Therapy (2005)

Previously, we have shown that to circumvent T cell tolerance to the Wilms tumor antiegn-1 (WT1), cytotoxic T lymphocytes (CTL) specific for an HLA-A2-presented peptide epitope of the WT1 have been generated from allogeneic donors, and these CTL can selectively kill immature human leukemia progenitor and stem cells in vitro. In this study we have isolated the T cell receptor (TCR) genes of an allorestricted CTL line for retroviral gene transfer into T lymphocytes obtained from both leukemia patients and healthy donors. Here we show that TCR transduced CTL kill T2 target cells coated with the WT1 peptide but not with irrelevant peptide, and these T cells also kill leukemia cells in vitro and display WT1-specific cytokine production. Intravenous injection of TCR transduced T cells into NOD/SCID mice harbouring human leukemia cells resulted in leukaemia elimination, whilst transfer of control T cells transduced with an irrelevant TCR was ineffective. These data suggest that adoptive immunotherapy with WT1-TCR gene modified patient T cells should be considered for the treatment of human leukemia.
Abstract 3539: Overexpression of the ATP Binding Cassette Gene ABCA1 determines resistance to curcumin in M14 melanoma cells
Authors: Emanuel Kronski, Cristina M. Iancu, Peter Killian, Valentina Mirisola, Marianne Jochum, Andreas Nerlich, Ulrich Pfeffer, Beatrice Bachmeier
Journal: Cancer Research (2010)

Abstract Background: Curcumin induces apoptosis in many cancer cells and it reduces xenograft growth and the formation of lung metastases in nude mice. Moreover, the plant derived polyphenol has been reported to be able to overcome drug resistance to classical chemotherapy. These features render the drug a promising candidate for tumor therapy especially for cancers known for their high rates concerning therapy resistance like melanoma. Results: We show here that the melanoma cell line M14 is resistant to Curcumin induced apoptosis, which correlates with the absence of any effect on NFkappaB signaling. We show that CXCL1 a chemokine that is down regulated in breast cancer cells by Curcumin in an NFkappaB dependant manner is expressed at variable levels in human melanomas. Yet in M14 cells, CXCL1 expression did not change upon Curcumin treatment. Following the hypothesis that Curcumin is rapidly removed from the resistant cells, we analyzed expression of known multi drug resistance genes and cellular transporters in M14 melanoma cells and in the Curcumin sensitive breast cancer cell line MDA-MB-231. ATP-binding cassette transporter ABCA1, a gene involved in the cellular lipid removal pathway is over-expressed in resistant M14 melanoma as compared to the sensitive MDA-MB-231 breast cancer cells. Gene silencing of ABCA1 by siRNA sensitizes M14 cells to the apoptotic effect of Curcumin most likely as a result of reduced basal levels of active NFkappaB. Moreover, ABCA1 silencing alone also induces apoptosis and reduces p65 expression. Conclusion: Resistance to Curcumin thus follows classical pathways and ABCA1 expression should be considered as response marker. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3539.
Accommodating Planned Exercise in Type I Diabetic Patients on Intensive Treatment
Authors: A Schiffrin, Sagar Parikh
Journal: Diabetes Care (1985)

To achieve optimal metabolic control in type I diabetic patients treated with continuous subcutaneous insulin infusion (CSII) and multiple subcutaneous injections of insulin (MSI) appropriate adjustments of the insulin prescription should be made for exercise, which is a normal component of everyday life. The present study describes the responses of seven type I diabetic adolescents treated with CSII and six patients treated with MSI to specific insulin dose changes in anticipation of postprandial exercise. The effect of 45 min of cycle ergometer exercise at 55% VO2 on glucose regulation was studied 2 h after morning insulin and a breakfast meal. To quantify the potential benefit of modifying the insulin dose before exercise, the subjects were studied on five different days in a random order: (1) resting control day, (2) postprandial exercise preceded by the usual dose of insulin, (3) postprandial exercise preceded by one-half of the usual dose of insulin, (4) postprandial exercise preceded by two-thirds of the usual dose of insulin, and (5) postprandial exercise without the usual dose of insulin. In all cases insulin was injected or infused subcutaneously in the anterior abdominal wall. When exercise was performed without changing the usual insulin dose, there was a significant fall in glycemia in both groups, with the nadir occurring after 45 min. In the CSII group, the ± SEM plasma glucose was 57 ± 5 mg/dl (P &amp;lt; 0.05 versus rest) with hypoglycemia occurring in four patients. In the MSI group, the mean ± SEM plasma glucose fell to 65 ± 10 mg/dl (P &amp;lt; 0.05 versus rest) and hypoglycemia occurred in three patients. This was corrected with the administration of approximately 25 g of glucose by mouth. When exercise was performed after one-half and two-thirds of the usual insulin dose, the plasma glucose profile observed during exercise in both groups was not statistically different from that observed during the rest day. Postprandial exercise without prior insulin resulted in significant hyperglycemia in both groups (P &amp;lt; 0.01). Plasma free insulin levels remained unchanged throughout the exercise period in all protocols. A 50–66% reduction of the insulin dose in anticipation of postprandial exercise of moderate intensity resulted in near-normal glycemic values and prevented hypoglycemia. Alternatively, in the case of unplanned postprandial exercise of 45 min duration, the intake of 25–30 g of glucose may prevent hypoglycemia in the CSII- and MSI-treated type I diabetic patients.
Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn's disease and ulcerative colitis
Authors: A Sturm
Journal: Gut (2004)

Different abnormalities of T cell effector function distinguish Crohn's disease (CD) from ulcerative colitis (UC). Because cell cycling determines effector function, pathogenic events in CD and UC may depend on cell cycle changes unique to each condition.Cell cycle kinetics, cycle regulatory molecule expression, apoptosis, caspase and telomerase activity, and cellular expansion were evaluated in CD2 and CD3 activated control, CD, and UC lamina propria T cells.Compared with normal cells, CD T cells cycle faster, express increased phosphorylated Rb and decreased phosphorylated p53 levels, display less caspase activity but more telomerase activity, die less, and undergo vigorous cellular expansion. In contrast, UC T cells cycle slower, express normal levels of phosphorylated Rb and p53, display more caspase activity but have no telomerase activity, die more, and have a limited capacity to expand.T cell cycle abnormalities in CD indicate a state of hyperreactivity compatible with loss of tolerance, but a hyporeactive state compatible with anergy in UC. Thus distinct and divergent T cell cycle characteristics underlie the pathogenesis of the two main forms of inflammatory bowel disease.
The Exceptional Child in the Family: Helping Parents of Exceptional Children
Authors: Marjorie C. Meehan
Journal: JAMA (1964)

Although no child is completely normal or fails to present problems to his parents, there are some groups of children who deviate so greatly from the average that they create special difficulties. The crippled, the blind or deaf, the mentally retarded or emotionally disturbed, as well as adopted children or the unusually gifted, all require special attention and may be described as "exceptional." While their problems vary, they have in common the quality of being unusual and the consequent insecurity felt by themselves and their families. Alan Ross, a child psychologist, wrote this book as a guide for the professional personnel—doctors, nurses, social workers, educators— who must advise the parents of exceptional children. What doctor, regardless of specialty, does not occasionally have this difficult task? Ross does not attempt to discuss all the problems of each type of handicap, or to answer such specific questions as whether bright children should
Type of disinfectant in drinking water and patterns of mortality in Massachusetts.
Authors: S Zierler, R A Danley, L Feingold
Journal: Environmental Health Perspectives (1986)

Chlorination has been the major strategy for disinfection of drinking water in the United States. Concern about the potential health effects of the reaction by-products of chlorine has prompted use of alternative strategies. One such method is chloramination, a treatment process that does not appear to have carcinogenic by-products, but may have less potent biocidal activity than chlorination. We examined the patterns of mortality of residents in Massachusetts who died between 1969 and 1983 and lived in communities using drinking water that was disinfected either by chlorine or chloramine. Comparison of type of disinfectant among 51,645 cases of deaths due to selected cancer sites and 214,988 controls who died from cardiovascular, cerebrovascular, or pulmonary disease, or from lymphatic cancer showed small variation in the patterns of mortality. Bladder cancer was moderately associated with residence at death in a chlorinated community (mortality odds ratio = 1.7, 95% confidence interval = 1.3-2.2) in a logistic regression analysis using controls who died from lymphatic cancer. A slight excess of deaths from pneumonia and influenza was observed in communities whose residents drank chloraminated water compared to residents from chlorinated communities, as well as to all Massachusetts residents (standardized mortality ratio = 118, 95% confidence interval = 116-120 for chloraminated communities, and standardized mortality ratio = 98, 95% confidence interval = 95-100 for chlorinated communities). These results are intended to be preliminary and crude descriptions of the relationship under study.(ABSTRACT TRUNCATED AT 250 WORDS)
Reye's Syndrome Among Patients With Juvenile Rheumatoid Arthritis
Authors: Kevin M. Sullivan
Journal: JAMA (1988)

<h3>To the Editor. —</h3> The JOURNALhas presented convincing evidence from case-control studies that aspirin use among children increases the risk for Reye's syndrome.<sup>1-3</sup>In recent years, there has been a dramatic decline in the reported incidence of Reye's syndrome nationally, which has paralleled the decline in the use of aspirin.<sup>4</sup>More recently, Sienko et al<sup>5</sup>reported further supporting population-based evidence for the association between aspirin and Reye's syndrome, stating that decreasing aspirin use has made Reye's syndrome an "endangered syndrome." We would like to address the possible concern regarding children who routinely take aspirin for chronic illnesses. Two studies<sup>6,7</sup>have shown that children who take aspirin routinely are at increased risk of Reye's syndrome. While the prevalence of juvenile rheumatoid arthritis (JRA) has been estimated to range from 0.1 to 1.1 per 1000 children,<sup>6</sup>a hospital-based study<sup>7</sup>of Reye's syndrome found a disproportionate
An interesting case of acute abdomen
Authors: R. Durai, S. Kumar, S.-N. Ruhomauly, H. Hoque
Journal: BMJ (2008)

A 61 year old man presented with a ten day history of right sided non-colicky abdominal pain radiating to the back, and four episodes of fever with rigor, each of which lasted an hour. He had no other gastrointestinal or urinary symptoms. His only medical history was a ureteric stone. He did not take any drugs, and drunk alcohol in moderate amounts regularly. 

On examination he seemed well, apyrexial but tachycardic with a pulse rate of 110 beats per minute. His blood pressure was normal. His chest was clear. Examination of his abdomen showed a tender 15×10 cm swelling in the right anterior lumbar region. 

Chest radiograph did not show pneumoperitoneum. His blood test showed neutrophilia (20×109/l and a raised C reactive protein of 200 mg/l. The rest of the blood tests including amylase were in the normal range. An abdominal radiograph and computed tomogram of the abdomen and pelvis were performed.⇓



1 What can you see in the abdominal computed tomogram?

2 What is the diagnosis and why?

3 How would you treat this condition?

### Short answers

1 The abdominal computed tomogram shows an 11×7 cm abscess (figure 1)⇑ with an air fluid level. It adheres to the right anterior abdominal wall, medial to the caecum and the ascending colon.

2 The abscess is separate from the small bowel and is most likely to be …
Recovery from Acute Phenobarbital Intoxication After Prolonged Coma
Authors: Leroy D. Vandam
Journal: JAMA (1963)

THIS REPORT of recovery from acute phenobarbital intoxication is, we believe, of general interest because of the high blood concentration of barbiturate initially found, the prolonged coma that followed, and the simplicity of the therapeutic approach. Despite recent developments in the treatment of barbiturate poisoning, the experience recorded here reaffirms faith in the essentiality of supportive treatment for the unconscious patient particularly as it may be applied in a relatively isolated community hospital. <h3>Report of a Case</h3> A 39-yr-old married woman was admitted unconscious to the hospital at 8:30 am on Aug 10, 1962. There was a history of several hospital admissions for symptoms of spastic colitis and for infrequent transient blackouts. A cholecystectomy had been performed sometime in the past. She had been taking 15 mg of phenobarbital 4 times daily, 100 mg of dephenylhydantoin (Dilantin) twice daily, and three to four 2-mg tablets of perphenazine (Trilafon) a day
Eliminating Rubella From the United States
Authors: William Kindrachuk
Journal: JAMA (1986)

<h3>To the Editor.—</h3> In the article entitled "The Opportunity and Obligation to Eliminate Rubella From the United States," Orenstein et al<sup>1</sup>advise physicians "to vaccinate susceptible adults especially women of childbearing age when they bring in their infants and children for routine well-baby care and immunizations." Since April, I have tried to find mothers who may be in need of rubella vaccine and have been unsuccessful. Mothers vaguely recall blood having been drawn by the delivering physician, but few recall the exact status of their rubella immunity. Furthermore, discussion about future or actual hysterectomy, tubal ligation, vasectomy, and pregnancy ensues and brings up interesting possibilities, but does not help in determining rubella immunity. In short, this specific approach suggested by Orenstein et al has been neither practical nor useful. Have the authors had successful experience or are they familiar with effective programs that have identified and vaccinated mothers in
Physical therapy in chronic bronchitis.
Authors: D Newton
Journal: BMJ (1979)

window seal.The fact that the authors did not find a perilymph fistula does not exclude this possibility as they can heal very rapidly, as after routine stapedectomy.I note that tinnitus and nausea had resolved by the time of surgery.Incidentally, experimental inocula- tion of mumps virus at the oval window does not lead to labyrinthitis in monkeys.
Thrombospondin 1 Is an Autocrine Negative Regulator of Human Dendritic Cell Activation
Authors: Virginie Doyen, Manuel Rubio, Deborah Braun, Toshiaru Nakajima, Jun Abe, Hirohisa Saito, Guy Delespesse, Marika Sarfati
Journal: The Journal of Experimental Medicine (2003)

Thrombospondin 1 (TSP) elicits potent antiinflammatory activities in vivo, as evidenced by persistent, multiorgan inflammation in TSP null mice. Herein, we report that DCs represent an abundant source of TSP at steady state and during activation. Human monocyte-derived immature dendritic cells (iDCs) spontaneously produce TSP, which is strongly enhanced by PGE2 and to a lesser extent by transforming growth factor (TGF) β, two soluble mediators secreted by macrophages after engulfment of damaged tissues. Shortly after activation via danger signals, DCs transiently produce interleukin (IL) 12 and tumor necrosis factor (TNF) α, thereby eliciting protective and inflammatory immune responses. Microbial stimuli increase TSP production, which is further enhanced by IL-10 or TGF-β. The endogenous TSP produced during early DC activation negatively regulates IL-12, TNF-α, and IL-10 release through its interactions with CD47 and CD36. After prolonged activation, DCs extinguish their cytokine synthesis and become refractory to subsequent stimulation, thereby favoring the return to steady state. Such “exhausted” DCs continue to release TSP but not IL-10. Disrupting TSP–CD47 interactions during their restimulation restores their cytokine production. We conclude that DC-derived TSP serves as a previously unappreciated negative regulator contributing to arrest of cytokine production, further supporting its fundamental role in vivo in the active resolution of inflammation and maintenance of steady state.
2-[F-18]FLUORO-2-DEOXY-D-GLUCOSE POSITRON EMISSION TOMOGRAPHY (PET-FDG) IN THE ASSESSMENT OF PRIMARY AND RECURRENT HEAD AND NECK CANCER
Authors: D. Lamonica, L. Steinbrenner, M. Spaulding, L. Meyers, H. Simpson, P. Galantowicz, V Cronin, H. Abdel-Nabi
Journal: Clinical Nuclear Medicine (1995)

Lamonica, D.; Steinbrenner, L.; Spaulding, M.; Meyers, L.; Simpson, H.; Galantowicz, P.; Cronin, V; Abdel-Nabi, H. Author Information
THE PSYCHIATRIC SIDE-EFFECTS OF IPRONIAZID
Authors: GEORGE E. CRANE
Journal: American Journal of Psychiatry (1956)

Iproniazid is a powerful stimulant which can be very useful in the treatment of debilitated individuals. Its use is limited because of the severity and frequency of side-effects. The psychiatric complications are more frequent than the systemic or neurological toxic reactions. Poor psychiatric risks should not be treated with Iproniazid; all patients receiving the drug should be under constant psychiatric observation.
Mycobacterium tuberculosis Bacteremia and Disseminated Coagulation
Authors: John P. Manzella
Journal: JAMA (1985)

<h3>To the Editor.—</h3> There have been few case reports of culture-proved mycobacteremia due to<i>Mycobacterium tuberculosis</i>.<sup>1,2</sup>Using the Isolator lysis centrifugation blood culture system, we documented<i>M tuberculosis</i>bacteremia in a patient with disseminated tuberculosis and disseminated coagulation (DIC). <h3>Report of a Case.—</h3> A 71-year-old man was admitted to the hospital with a one-week history of productive cough and intermittent temperature elevations to 40 °C. Five years earlier, the result of an intermediate-strength purified protein derivative skin test was positive and several sputum samples for acid-fast bacilli were obtained and yielded no growth. Physical findings included a blood pressure of 102/80 mm Hg; pulse rate, 90 beats per minute; respirations, 16/min; and temperature, 38.5 °C. No petechiae or ecchymoses were seen; the fundi were normal and there was no adenopathy. Chest examination revealed bibasilar rales, cardiac examination findings were normal, and the abdomen revealed no tenderness or organomegaly. Laboratory
Endoscopic Incision of Choledochal Cysts (Choledochocele)
Authors: J.H. Siegel, G.T. Harding, F. Chateau
Journal: Endoscopy (1981)

Congenital cysts of the ble ducts and liver usually present with symptoms of compression, obstruction or infection. The management of these problems has been the surgical approach with extirpation or diversion techniques. Cysts of the common hepatic or bile ducts should be completely excised if possible while intrahepatic cysts are treated by anastomosis of the ducts to isolated intestinal loops. Diversion techniques for distal intraduodenal cysts leads to development of the sump syndrome, and, it has been our experience in two patients to treat these, choledochocele, by incision during performance of a sphincterotomy.
Pantoun on Lines by William Osler
Authors: Jack Coulehan
Journal: JAMA (2009)

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A graphical method for detecting recombination in phylogenetic data sets
Authors: G. McGuire, F. Wright, M. J. Prentice
Journal: Molecular Biology and Evolution (1997)

Current phylogenetic tree reconstruction methods assume that there is a single underlying tree topology for all sites along the sequence. The presence of mosaic sequences due to recombination violates this assumption and will cause phylogenetic methods to give misleading results due to the imposition of a single tree topology on all sites. The detection of mosaic sequences caused by recombination is therefore an important first step in phylogenetic analysis. A graphical method for the detection of recombination, based on the least squares method of phylogenetic estimation, is presented here. This method locates putative recombination breakpoints by moving a window along the sequence. The performance of the method is assessed by simulation and by its application to a real data set.