tbuckley/cabot-search huggingface dataset:
Endoscopic Resection of Ampullary Carcinoma
Authors: P. Neves, M. Leitão, F. Portela, J. M. Pontes, M. Areia, D. Brito, H. T. Sousa, P. Souto, E. Camacho, P. Andrade, H. Gouveia, D. Freitas
Journal: Endoscopy (2006)

Endoscopic resection may be an appropriate alternative treatment in selected patients with ampullary tumors [1] [2].
Public Policy Governing Organ and Tissue Procurement
Authors: Laura A. Siminoff
Journal: Annals of Internal Medicine (1996)

Letters1 February 1996Public Policy Governing Organ and Tissue ProcurementLaura A. Siminoff, PhD, Robert Arnold, MD, and Arthur Caplan, PhDLaura A. Siminoff, PhDUniversity of Pittsburgh; Pittsburgh, PA 15213University of Pennsylvania; Philadelphia, PA 19104Search for more papers by this author, Robert Arnold, MDUniversity of Pittsburgh; Pittsburgh, PA 15213University of Pennsylvania; Philadelphia, PA 19104Search for more papers by this author, and Arthur Caplan, PhDUniversity of Pittsburgh; Pittsburgh, PA 15213University of Pennsylvania; Philadelphia, PA 19104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-3-199602010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Large segments of the U.S. public have serious reservations about organ donation. Dr. Spital questions our interpretation of Hessing and colleagues' study [1], which found that 18.2% of respondents reported a fear of being declared dead too soon and a significant association with willingness to donate. A fear reported by 18.2% of the population would be considered “common” by most social scientists.Seltzer, Siminoff, and Arnold presented data at the Third Biennial Conference on Psychiatric, Psychosocial and Ethical Issues in Organ Transplantation showing that 28.0% (n = 414) of respondents reported agreeing with the statement “I worry that ...References1. Hessing DJ, Elffers H. Attitude toward death, fear of being declared dead too soon, and donation of organs after death. OMEGA. 1986-1987; 17:115-26. Google Scholar2. Seltzer DL, Siminoff LA, Arnold RM. Public attitudes concerning organ donation and transplantations and alternative procurement procedures. Third Biennial Conference on Psychiatric, Psychosocial and Ethical Issues in Organ Transplantation. Richmond, VA, 5-6 October 1994. Google Scholar Author, Article, and Disclosure InformationAuthors: Laura A. Siminoff, PhD; Robert Arnold, MD; Arthur Caplan, PhDAffiliations: University of Pittsburgh; Pittsburgh, PA 15213University of Pennsylvania; Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1996Volume 124, Issue 3 Page: 374-375 Keywords Fear Organ transplantation Prevention, policy, and public health Public policy Scientists ePublished: 15 August 2000 Issue Published: 1 February 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
X Inactivation in Females with X-Linked Disease
Authors: Jennifer M. Puck, Huntington F. Willard
Journal: New England Journal of Medicine (1998)

X-linked recessive disorders affect males, whereas female carriers are generally spared. This is due in part to the random inactivation in females of one of the two X chromosomes in all somatic cells. Normal females are thus a mosaic of two cell populations, each expressing the alleles from one X chromosome or the other. Thus, in female carriers of an X-linked mutation, approximately 50 percent of cells on average have the normal allele on the active X chromosome (with the mutant allele being on the inactive X chromosome), and these functionally normal cells are generally sufficient to spare females from . . .
Rheumatology outpatient training: Time for a re-think?
Authors: J E McDONAGH
Journal: Annals of the Rheumatic Diseases (1997)

Rheumatology, as a specialty, presents the education and training process with particular challenges. The rheumatology trainee is likely to spend more time alone seeing patients in an outpatient clinic than on ward rounds with bedside teaching. Whereas the teaching ward round is still a familiar phenomenon in hospital medicine, true ‘teaching clinics’ are still in their infancy. With heightened patient expectations, financial constraints, and increasing workloads, there is a growing concern of how an appropriate balance between training and service will be maintained for rheumatology trainees in the outpatient ‘classroom’.

In contrast with inpatient teaching, time is more limited in outpatient clinics for in depth discussion, opportunity to probe the trainee’s knowledge of cases, and to observe the patient-trainee interaction. Furthermore, there is limited time to demonstrate clinical skills, to reflect upon the experience, and for assessment and feedback. A recent North American review of research literature on education in the outpatient setting for both medical undergraduates and graduates during the period 1980–1994, reported it to be characterised by variability, unpredictability, immediacy, and lack of continuity with comparatively few cases discussed with the attending physician and even fewer examined by them.1 

Rheumatology education has been discussed in this journal from various viewpoints.2-4 The aim of this editorial is specifically to consider the issues implicit in teaching in outpatient departments, which is where most future clinical specialist rheumatology training will take place. Hopefully discussion will thus be stimulated and imagination ‘fired’ in this most important area of postgraduate education. For the remainder of the text ‘trainee’ will refer to the specialist registrar grade and ‘trainer’ to the consultant grade.

‘You learn as you go along’

In recent years, rheumatology postgraduate training has often followed, right or wrong, the ‘learn as you go along’ approach. Learning from isolated clinical experience …
Abstract 2795: Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.
Authors: Ryuhei Tada, Hiromasa Yamamoto, Masashi Furukawa, Kazuhiko Shien, Shinsuke Hashida, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichi Toyooka, Shinichiro Miyoshi
Journal: Cancer Research (2013)

Abstract Malignant pleural mesothelioma (MPM) is a poor prognostic malignancy that is distinctly resistant to the conventional therapies. Cell lines are useful materials for studying the biological characteristics of the tumors, thus the establishment of MPM cell lines is valuable for exploring the new therapeutic strategies of MPM. We established 4 MPM cell lines (YUMC8, YUMC44, YUMC63 and YUMC64) from Japanese patients, consisting of 2 epithelioid and 2 sarcomatoid types for histological subtype. We analyzed the status of methylation, mutation, copy number gains (CNGs), and protein expression in representative genes and the sensitivity to several drugs in these 4 cell lines. We detected the complete methylation of P16 in 3 cell lines, in which the protein expression of p16 was lost. Methylation of RASSF1A was observed in 3 of 4 cell lines. Copy number gains (CNGs) in EGFR, HER2 and MET were not detected in all the cell lines. Mutations in various genes including EGFR, KRAS, HER2, BRAF, and PIK3CA, which are frequently detected in non-small cell lung cancer, were not detected in all 4 cell lines. As for microRNA, miR-34b/c was completely methylated in 2 of 4 MPM established cell lines. About cell adhesion molecules, E-cadherin expression was detected in two epithelioid type MPM cell lines, whereas N-cadherin expression was detected in all four established cell lines by Western blot analysis. Vimentin was strongly expressed in two sarcomatoid type MPM cell lines. All established MPM cell lines showed no dramatic responses to the drugs tested including NVP-AUY922, 17-DMAG, Trichostatin A and Vorinostat. Although new molecular findings were not observed in the process of the current characterization of these new MPM cell lines, they seem to be useful for the future extensive analyses of biological behavior of MPM, so as to the development of new therapeutic strategies. Citation Format: Ryuhei Tada, Hiromasa Yamamoto, Masashi Furukawa, Kazuhiko Shien, Shinsuke Hashida, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichi Toyooka, Shinichiro Miyoshi. Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2795. doi:10.1158/1538-7445.AM2013-2795
Comparative hospitalization of hemodialysis and peritoneal dialysis patients in Canada
Authors: Sean W. Murphy, Robert N. Foley, Brendan J. Barrett, Gloria M. Kent, Janet Morgan, Paul Barré, Patricia Campbell, Adrian Fine, Marc B. Goldstein, S. Paul Handa, Kailash K. Jindal, Adeera Levin, Henry Mandin, Norman Muirhead, Robert M.A. Richardson, Patrick S. Parfrey
Journal: Kidney International (2000)
Positive and negative prediction of sustained virologic response at weeks 2 and 4 of treatment with albinterferon alfa-2b or peginterferon alfa-2a in treatment-naïve patients with genotype 1, chronic hepatitis C
Authors: Avidan U. Neumann, Stephen Pianko, Stefan Zeuzem, Eric M. Yoshida, Yves Benhamou, Moshe Mishan, John G. McHutchison, Erik Pulkstenis, G. Mani Subramanian
Journal: Journal of Hepatology (2009)
Statistical Discrimination of Male Myocardial Infarction Patients and Healthy Males by Means of a Psychological Test and a Tracing of Basic Dimensions of the Infarction Personality
Authors: H. van Dijl, N. Nagelkerke
Journal: Psychotherapy and Psychosomatics (1980)

434 male MI patients and 731 'healthy' controls filled out the retrospective RSL psychological questionnaire. This test has shown to discriminate significantly between a considerable number of clinical statements describing MI patients, and a healthy population. A principal factor analysis (with Varimax rotation) on 27 discriminating items from a multivariate discriminant function produced four factors: depressiveness, hostility, work involvement, and job responsibility. The dimensions of work involvement, and job responsibility are well known from other studies on psychological characteristics of the assumed MI personality. The dimensions of depressiveness and hostility, however, may constitute important new contributions.
Mesoridazine Versus Chlorpromazine in Acute Schizophrenia: A Double-Blind Investigation
Authors: T. A. HAMID, WILLIAM J. WERTZ
Journal: American Journal of Psychiatry (1973)

A double-blind comparison of mesoridazine and chlorpromazine with 91 newly admitted, acutely psychotic patients showed that symptoms grouped in the following composites improved significantly more in the mesoridazine patients than in the chlorpromazine patients: motor activity, attitude and behavior, emotional response, and ideation and thought processes. The mesoridazine patients experienced less sedation than the chlorpromazine patients.
Improvement of White Matter Changes on Neuroimaging Modalities After Stem Cell Transplant in Metachromatic Leukodystrophy
Authors: Martje E. van Egmond, Petra J. W. Pouwels, Jaap-Jan Boelens, Caroline A. Lindemans, Frederik Barkhof, Martijn D. Steenwijk, Peter M. van Hasselt, Marjo S. van der Knaap, Nicole I. Wolf
Journal: JAMA Neurology (2013)

We sought to illustrate improvement of cerebral white matter changes in metachromatic leukodystrophy after treatment with hematopoietic stem cell transplant (HSCT).We conducted serial magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS) as standard follow-up after HSCT with cord blood in 1 patient with juvenile metachromatic leukodystrophy diagnosed before frank degenerative symptoms developed. We measured MRI and 1H-MRS changes. The white matter changes first increased after HSCT, then decreased in relation to the pre-HSCT MRI and 1H-MRS.Hematopoietic stem cell transplant, if performed early in metachromatic leukodystrophy, can not only stabilize but even improve cerebral white matter abnormalities. Our findings suggest a biological effect of HSCT.
The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors
Authors: Vı́t Karafiát, Marta Dvořáková, Petr Pajer, Jarmila Králová, Zuzana Hořejšı́, Vladimı́r Čermák, Petr Bartůněk, Martin Zenke, Michal Dvořák
Journal: Blood (2001)
Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4
Authors: Frank Echtermeyer, Michael Streit, Sarah Wilcox-Adelman, Stefania Saoncella, Fabienne Denhez, Michael Detmar, Paul F. Goetinck
Journal: Journal of Clinical Investigation (2001)

The syndecans make up a family of transmembrane heparan sulfate proteoglycans that act as coreceptors with integrins and growth factor tyrosine kinase receptors. Syndecan-4 is upregulated in skin dermis after wounding, and, in cultured fibroblasts adherent to the ECM protein fibronectin, this proteoglycan signals cooperatively with β1 integrins. In this study, we generated mice in which the syndecan-4 gene was disrupted by homologous recombination in embryonic stem cells to test the hypothesis that syndecan-4 contributes to wound repair. Mice heterozygous or homozygous for the disrupted syndecan-4 gene are viable, fertile, and macroscopically indistinguishable from wild-type littermates. Compared with wild-type littermates, mice heterozygous or homozygous for the disrupted gene have statistically significant delayed healing of skin wounds and impaired angiogenesis in the granulation tissue. These results indicate that syndecan-4 is an important cell-surface receptor in wound healing and angiogenesis and that syndecan-4 is haplo-insufficient in these processes.
Cocaine-Induced Cerebral Vasoconstriction Detected in Humans With Magnetic Resonance Angiography
Authors: Marc J. Kaufman, Jonathan M. Levin, Marjorie H. Ross, Nicholas Lange, Stephanie L. Rose, Thellea J. Kukes, Jack H. Mendelson, Scott E. Lukas, Bruce M. Cohen, Perry F. Renshaw
Journal: JAMA (1998)

Clinical observations and case reports suggest that there are important cerebrovascular complications of cocaine use, but no studies have documented a direct link.To determine whether low-dose cocaine administration induces cerebral vasoconstriction in healthy cocaine users.Randomized controlled trial.Twenty-four healthy and neurologically normal men (mean age, 29 years) reporting median cocaine use of 8 lifetime exposures (range, 3 to >40).Double-blind intravenous administration of cocaine (0.4 or 0.2 mg/kg) or placebo, with cerebral magnetic resonance angiography performed at baseline and 20 minutes following infusion.Cocaine-induced angiographic change indicative of vasoconstriction, as independently and concordantly rated by 2 reviewers blind to treatment condition.Cocaine-induced cerebral vasoconstriction in a dose-related fashion (P=.03), with angiograms indicative of vasoconstriction found in 5 of 8 and 3 of 9 subjects receiving 0.4- and 0.2-mg/kg cocaine, respectively, compared with 1 of 7 subjects administered placebo. Outcome stratification by frequency of self-reported lifetime cocaine use (3-10 times, 11-40 times, or >40 times) revealed a statistically stronger dose-related effect (P<.001), suggesting that greater lifetime cocaine use was associated with a greater likelihood of vasoconstriction.Cocaine administration induced dose-related cerebral vasoconstriction on magnetic resonance angiograms. These changes occurred at low cocaine doses and in the absence of other risk factors, including polydrug abuse, hypertension, or cerebrovascular disease. Outcome stratification by prior cocaine use statistically strengthened the relationship between cocaine administration and vasoconstriction, suggesting that cocaine may have a cumulative residual effect in promoting cerebrovascular dysfunction.
Scintigraphic Findings in a Case of Variant Mirizzi Syndrome
Authors: ALKA KUMAR, SHASHI AGGARWAL, SIAN E. ILES, DAVID C. BARNES
Journal: Clinical Nuclear Medicine (1991)

Mirizzi syndrome has over the years been characterized by four components: the presence of an impacted stone either in the cystic duct or in Hartmann's pouch; an anatomic variation of the cystic duct so that it lies almost parallel to the common bile duct; partial mechanical obstruction of the common bile duct either by the calculus or resultant inflammation; and, at times, associated cholangitis. The definition has been broadened to include other biliary tract diseases, as well, such as carcinoma of the gallbladder, primary cystic duct carcinoma, and inflammatory stricture of the common hepatic duct. They have in common extrinsic compression of the common bile duct. The resulting syndrome has been called Mirizzi syndrome, or one of its variants, and it can cause obstructive jaundice. Features of this syndrome have been identified by noninvasive as well as by invasive imaging modalities, but they have not been adequately addressed in nuclear medicine. The authors present the scintigraphic findings in a proven case of acute cholecystitis causing acute, complete bile duct obstruction (variant Mirizzi syndrome).
Racial differences in primary cytogenetic abnormalities in multiple myeloma: a multi-center study
Authors: A J Greenberg, S Philip, A Paner, S Velinova, A Badros, R Catchatourian, R Ketterling, R A Kyle, S Kumar, C M Vachon, S V Rajkumar
Journal: Blood Cancer Journal (2015)

We examined four clinically assessed cytogenetic subtypes (t(11;14), t(4;14), monosomy 13/del13q and monosomy 17/del17p in 292 black patients with newly diagnosed multiple myeloma (MM) from four medical centers, who had fluorescent in situ hybridization testing results available in their medical records. We then compared the prevalence of these abnormalities with a previously characterized Mayo Clinic cohort of 471 patients with MM. We found a significant difference in the prevalence of the t(11;14) immunoglobulin heavy chain (IgH) translocation between blacks and whites, 6.5% versus 17.6%, respectively, P<0.0001. Blacks also had lower rates of the t(4;14) IgH translocation, (5.5% versus 10%); monosomy 13/del13q (29.1 versus 49.3%); and monosomy 17/del17p (7.9% versus 13%). Consequently, 63.4% of blacks versus 34.6% of whites did not have any of the four abnormalities that we studied, P<0.001. As almost all MM is associated with either an IgH translocation or trisomies, we hypothesize that MM in blacks is associated with either excess prevalence of either the trisomic (hyperdiploid) form of MM or an IgH translocation besides t(11;14) or t(4;14). We conclude that there are significant differences in the cytogenetic subtypes of MM that occur in blacks and whites.
Semaphorin 5A Is a Bifunctional Axon Guidance Cue Regulated by Heparan and Chondroitin Sulfate Proteoglycans
Authors: David B. Kantor, Onanong Chivatakarn, Katherine L. Peer, Stephen F. Oster, Masaru Inatani, Michael J. Hansen, John G. Flanagan, Yu Yamaguchi, David W. Sretavan, Roman J. Giger, Alex L. Kolodkin
Journal: Neuron (2004)
Coordinate-Free Analysis of Mitral Valve Dynamics in Normal and Ischemic Hearts
Authors: P. Dagum, T. A. Timek, G. R. Green, D. Lai, G. T. Daughters, D. H. Liang, M. Hayase, N. B. Ingels, D. C. Miller
Journal: Circulation (2000)

The purpose of this investigation was to study mitral valve 3D geometry and dynamics by using a coordinate-free system in normal and ischemic hearts to gain mechanistic insight into normal valve function, valve dysfunction during ischemic mitral regurgitation (IMR), and the treatment effects of ring annuloplasty.Radiopaque markers were implanted in sheep: 9 in the ventricle, 1 on each papillary tip, 8 around the mitral annulus, and 1 on each leaflet edge midpoint. One group served as a control (n=7); all others underwent flexible Tailor partial (n=5) or Duran complete (n=6) ring annuloplasty. After an 8+/-2-day recovery, 3D marker coordinates were measured with biplane videofluoroscopy before and during posterolateral left ventricular ischemia, and MR was assessed by color Doppler echocardiography. Papillary to annular distances remained constant throughout the cardiac cycle in normal hearts, during ischemia, and after ring annuloplasty with either type of ring. Papillary to leaflet edge distances similarly remained constant throughout ejection. During ischemia, however, the absolute distances from the papillary tips to the annulus changed in a manner consistent with leaflet tethering, and IMR was observed. In contrast, during ischemia in either ring group, those distances did not change from preischemia, and no IMR was observed.This analysis uncovered a simple pattern of relatively constant intracardiac distances that describes the 3D geometry and dynamics of the papillary tips and leaflet edges from the dynamic mitral annulus. Ischemia perturbed the papillary-annular distances, and IMR occurred. Either type of ring annuloplasty prevented such changes, preserved papillary-annular distances, and prevented IMR.
Blood Glucose Concentration Influences Postprandial Fullness in IDDM
Authors: KL Jones, M Horowitz, M Berry, JM Wishart, S Guha
Journal: Diabetes Care (1997)

OBJECTIVE Upper gastrointestinal (GI) symptoms and delayed gastric emptying both occur frequently in patients with long-standing IDDM, but the relationship between them is relatively weak. Recent studies in normal subjects have indicated that blood glucose concentration may increase the perception of sensations arising from the upper GI tract. The purpose of this study was to examine the relationships among postprandial fullness, the rate of gastric emptying, and blood glucose concentration in IDDM patients. RESEARCH DESIGN AND METHODS We studied measurements of gastric emptying, blood glucose concentrations, cardiovascular autonomic nerve function, upper GI symptoms, and postprandial hunger and fullness in 40 IDDM patients (16 men, 24 women). ages 19–63 years. Gastric emptying of solids and liquids was measured scintigraphically, upper GI symptoms were measured by questionnaire immediately before ingestion of the test meal, and fullness and hunger were measured by visual analog scales every 15 min. Blood glucose concentrations were measured at −5, 30, 60, 90, and 120 min. RESULTS Solid gastric emptying was delayed in 58% of the patients, and both solid and liquid gastric emptying were slower (P &amp;lt; 0.05) in women than in men. The score for upper GI symptoms was not significantly related to gastric emptying. In contrast, postprandial fullness, but not hunger, was related to the amount of solid (r = 0.36, P &amp;lt; 0.05) but not liquid in the stomach. Both before (r = 0.39, P &amp;lt; 0.05) and after (r = 0.47, P &amp;lt; 0.01) the meal, fullness was related to blood glucose concentration. Postprandial fullness was also related to autonomic nerve dysfunction (r = 0.39, P &amp;lt; 0.05). Multiple regression analysis confirmed that blood glucose concentration, the rate of solid gastric emptying, and autonomic nerve dysfunction were independent determinants of postprandial fullness, together accounting for 47% of the variance. CONCLUSIONS These observations demonstrated that, in IDDM, postprandial fullness is influenced by blood glucose concentration, the rate of solid gastric emptying, and autonomic nerve function.