tbuckley/cabot-search huggingface dataset:
Abstract 124: Effect of RKIP on MMP expression and regulation of breast cancer metastasis
Authors: Ila J. Datar, Jingwei Feng, Gang Ren, Zehui Li, Xiaoliang Qiu, Fahd Al-Mulla, Milad S. Bitar, Miranda Yeung, Kam Yeung
Journal: Cancer Research (2014)

Abstract Raf Kinase Inhibitory Protein or RKIP was initially identified as a Raf-1 binding protein using the yeast 2-hybrid screen. RKIP inhibits the activation phosphorylation of MEK by Raf-1 by competitively inhibiting the binding of MEK to Raf-1 and thus exerting an inhibitory effect on the Raf-MEK-ERK pathway. RKIP has been identified as a metastasis suppressor gene. Metastasis is a complex multiple-step process. Expression of RKIP is low in cancer metastases. Although primary tumor growth was unaffected, re-expression of RKIP inhibits cancer metastasis. Mechanistically, RKIP constrains metastasis by inhibiting angiogenesis, local invasion, intravasation, and colonization. The molecular mechanism of how RKIP inhibits these individual steps remains undefined. Using an unbiased PCR based screening and by analyzing DNA microarray expression datasets we observed that the expression of multiple metalloproteases (MMP) including MMP1, MMP3, MMP10 and MMP13 were negatively correlated with RKIP expression in breast cancer cell lines and clinical samples. Since expression of MMPs by cancer cells is important for cancer metastasis, we hypothesize that RKIP may mediate suppression of breast cancer metastasis by inhibiting multiple MMPs. In this study we show that the expression signature of RKIP and MMPs is better at predicting high metastatic risk than the individual gene. Using a combination of loss- and gain-of-function approaches, we found that MMP13 is the cause of RKIP-mediated inhibition of local cancer invasion. Interestingly expression of MMP13 alone was not sufficient to reverse the inhibition of breast cancer cells metastasis to the lung due to the expression of RKIP. We found that RKIP negatively regulated MMP13 through the Erk2-Fra1 transcriptional axis and the repression of MMP13 by RKIP requires the presence of the a TPA-responsive element in the MMP13 proximal promoter. Together, our findings indicate that RKIP inhibits cancer cell invasion, in part, via MMP13 inhibition. These data also implicate RKIP in the regulation of MMPs transcription, suggesting a potential mechanism by which RKIP inhibits tumor progression and metastasis. Citation Format: Ila J. Datar, Jingwei Feng, Gang Ren, Zehui Li, Xiaoliang Qiu, Fahd Al-Mulla, Milad S. Bitar, Miranda Yeung, Kam Yeung. Effect of RKIP on MMP expression and regulation of breast cancer metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 124. doi:10.1158/1538-7445.AM2014-124
Myocardial Injury After Noncardiac Surgery and its Association With Short-Term Mortality
Authors: Judith A.R. van Waes, Hendrik M. Nathoe, Jurgen C. de Graaff, Hans Kemperman, Gert Jan de Borst, Linda M. Peelen, Wilton A. van Klei, Wolfgang F. Buhre, Jurgen C. de Graaff, Cor J. Kalkman, Wilton A. van Klei, Judith A.R. van Waes, Leo van Wolfswinkel, Pieter A. Doevendans, Hendrik M. Nathoe, Remco G. Grobben, Diederik E. Grobbee, Linda M. Peelen, Hans Kemperman, Wouter W. van Solinge, Tim Leiner, Gert Jan de Borst, Loek P.H. Leenen, Frans L. Moll
Journal: Circulation (2013)

Background— To identify patients at risk for postoperative myocardial injury and death, measuring cardiac troponin routinely after noncardiac surgery has been suggested. Such monitoring was implemented in our hospital. The aim of this study was to determine the predictive value of postoperative myocardial injury, as measured by troponin elevation, on 30-day mortality after noncardiac surgery. Methods and Results— This observational, single-center cohort study included 2232 consecutive intermediate- to high-risk noncardiac surgery patients aged ≥60 years who underwent surgery in 2011. Troponin was measured on the first 3 postoperative days. Log binomial regression analysis was used to estimate the association between postoperative myocardial injury (troponin I level &gt;0.06 μg/L) and all-cause 30-day mortality. Myocardial injury was found in 315 of 1627 patients in whom troponin I was measured (19%). All-cause death occurred in 56 patients (3%). The relative risk of a minor increase in troponin (0.07–0.59 μg/L) was 2.4 (95% confidence interval, 1.3–4.2; P &lt;0.01), and the relative risk of a 10- to 100-fold increase in troponin (≥0.60 μg/L) was 4.2 (95% confidence interval, 2.1–8.6; P &lt;0.01). A myocardial infarction according to the universal definition was diagnosed in 10 patients (0.6%), of whom 1 (0.06%) had ST-segment elevation myocardial infarction. Conclusions— Postoperative myocardial injury is an independent predictor of 30-day mortality after noncardiac surgery. Implementation of postoperative troponin monitoring as standard of care is feasible and may be helpful in improving the prognosis of patients undergoing noncardiac surgery.
Progressive bronchocentric granulomatosis: case report.
Authors: M D Clee, D Lamb, S J Urbaniak, R A Clark
Journal: Thorax (1982)

Bronchocentric granulomatosis was first described in 19731 and is characterised by a necrotising granulomatous des- truction of bronchial walls, bronchioles, and adjacent lung parenchyma.The bronchial lumen is filled by debris and cells, predominantly eosinophils in asthmatic patients and
Coronary Microvascular Resistance Index Immediately After Primary Percutaneous Coronary Intervention as a Predictor of the Transmural Extent of Infarction in Patients With ST-Segment Elevation Anterior Acute Myocardial Infarction
Authors: Hironori Kitabata, Toshio Imanishi, Takashi Kubo, Shigeho Takarada, Manabu Kashiwagi, Hiroki Matsumoto, Hiroto Tsujioka, Hideyuki Ikejima, Yu Arita, Keishi Okochi, Akio Kuroi, Satoshi Ueno, Hideaki Kataiwa, Takashi Tanimoto, Takashi Yamano, Kumiko Hirata, Nobuo Nakamura, Atsushi Tanaka, Masato Mizukoshi, Takashi Akasaka
Journal: JACC. Cardiovascular imaging (2009)
Defining “Community” in Emergency Preparedness
Authors: Mark P. Jarrett
Journal: Annals of Internal Medicine (2007)

Letters2 January 2007Defining “Community” in Emergency PreparednessMark P. Jarrett, MD, MBAMark P. Jarrett, MD, MBAFrom Staten Island University Hospital, Staten Island, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-1-200701020-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: The article by Braun and colleagues (1) underscores the need to accelerate integration of hospital disaster preparedness with community planning. The initial linkage for hospitals is with first responders: fire department, police department, and emergency medical service. Coordination of these services is usually provided by a governmental body, such as the Office of Emergency Management in New York City. It is clear, however, that, in a widespread disaster scenario, communities will need to be self-sufficient for at least the first 48 hours. This requires an expansion of the term “community” beyond hospitals and the agencies listed above. ...Reference1. Braun BI, Wineman NV, Finn NL, Barbera JA, Schmaltz SP, Loeb JM. Integrating hospitals into community emergency preparedness planning. Ann Intern Med. 2006;144:799-811. [PMID: 16754922] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Staten Island University Hospital, Staten Island, New York.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIntegrating Hospitals into Community Emergency Preparedness Planning Barbara I. Braun , Nicole V. Wineman , Nicole L. Finn , Joseph A. Barbera , Stephen P. Schmaltz , and Jerod M. Loeb Defining “Community” in Emergency Preparedness Barbara I. Braun , Nicole V. Wineman , Jerod M. Loeb , and Joseph A. Barbera Metrics Cited ByAnalysis of Gene Expression Changes in PHA-M Stimulated Lymphocytes – Unraveling PHA Activity as Prerequisite for Dicentric Chromosome AnalysisImproving Terrorism Preparedness for Hospitals: Toward Better Interorganizational Communication 2 January 2007Volume 146, Issue 1Page: 72KeywordsCommunication in health careConflicts of interestHealth careHealth care facilitiesHospitalsMedical dialysisPrevention, policy, and public healthTriage ePublished: 2 January 2007 Issue Published: 2 January 2007 CopyrightCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Discontinuation of Manufacture of Isocarboxazid
Authors: Julian Lieb
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Recently, I and several of my patients discovered that Hoffman-La Roche Inc had discontinued manufacturing isocarboxazid (Marplan). These patients, many of whom had episodes of delusional depression, were chronically ill before being placed on isocarboxazid. All had previously failed on trials of heterocyclic antidepressants as well as the other monoamine oxidase inhibitors. I assume that what Hoffman-La Roche does not comprehend is that there is a high level of specificity in response to antidepressants. Thus, even among those who selectively respond to monoamine oxidase inhibitors rather than to heterocyclics, almost none respond to all three inhibitors, some to two of the three, and many to only one. I currently am treating a woman who, in a 10-year period of recurrent psychotic depression, has had seven lengthy hospitalizations. Hoffman-La Roche's action will condemn this woman to a recurrence of suffering and her family to the burden of having
Who asks for vasectomy reversal and why?
Authors: G Howard
Journal: BMJ (1982)

Of the 76 men requesting reversal of vasectomy who were interviewed at Charing Cross Hospital between June 1978 and September 1981, 31 were still married. These men had decided to have a vasectomy during a crisis-a recent pregnancy or financial stress being the commonest reason. Most wanted another child but others wished to be "put back to normal," and a few hoped reversal would help their marriage. Forty-five (59%) were divorced or separated and felt disadvantaged in courtship or remarriage by being infertile, many wives or partners being "desperate" for a pregnancy. A greater number of requests for reversal came from men who had been under 35 at the time of vasectomy and who were more likely to have been divorced, especially if there had been a teenage pregnancy. The risks of regret after sterilisation appear to relate to immaturity at the time of the vasectomy and to be as great for young men as for young women.
Malaria from Viet Nam.
Authors: L. G. Hunsicker, Ronald A. Schwartz, Frank M. Barnwell
Journal: Annals of Internal Medicine (1967)

s1 May 1967Malaria from Viet Nam.L. G. Hunsicker, Ronald A. Schwartz, Frank M. BarnwellL. G. HunsickerSearch for more papers by this author, Ronald A. SchwartzSearch for more papers by this author, Frank M. BarnwellSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1046_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the period from September 1965 to February 1966 the U. S. Naval Hospital on Guam received 150 cases of malaria evacuated from the Republic of Viet Nam, mostly within a few days of their diagnosis. The clinical presentation of these patients was exceedingly varied. In many, gastrointestinal symptoms predominated; others had respiratory symptoms and the radiographic signs of bronchopneumonia. The most common complaints were retro-orbital headache, myalgias, and fever of varying and, at times, alarming degree.Of those treated with standard courses of chloroquine, 98% had recrudescences within a period of 30 days, and approximately 40% had no response... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug CombinationsThe narcotic addict as a medical patientInfectious diseases. Annual review of significant publications. 1 May 1967Volume 66, Issue 5Page: 1046-1046KeywordsChloroquineFeversHeadachesMalariaMyalgiaPneumonia Issue Published: 1 May 1967 PDF downloadLoading ...
Malabsorptive Effects of Neomycin in Commonly Used Doses
Authors: Eugene D. Jacobson
Journal: JAMA (1961)

The occurrence of malabsorption during the oral use of neomycin in large doses has been reported. A study of the effect of the commonly used daily doses of 4 to 6 Gm. has been carried out. Among 8 subjects receiving neomycin with carotene supplements, serum carotene fell sharply in 6 and resumed its premedication rise on withdrawal of neomycin. D-xylose absorption was measured in 4 of the subjects, and fat balance determination was carried out in one. Three of the 4 subjects showed a marked fall in d-xylose absorption, and fecal fat excretion doubled during the neomycin period. The results indicate that reversible intestinal malabsorption may occur with commonly used doses of neomycin.
"Normal" 0.9% Salt Solution Is Neither "Normal" Nor Physiological
Authors: Khalil G. Wakim
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In clinical and experimental literature, in circulars and house organs of the pharmaceutical industry, and on the labels of containers, the terms "normal saline" and "physiological saline" are commonly applied to 0.9% solution of sodium chloride. Although in long-standing usage and not of major significance, such terminology nevertheless is incorrect and should be avoided. At the risk of elucidating the obvious, I explain why it is wrong to designate 0.9% sodium chloride solution as "normal" or "physiological." A normal chemical solution of sodium chloride contains 58.5 gm/liter while a 0.9% solution contains only 9 gm/liter. Therefore, a normal chemical solution of sodium chloride is 6 1/2 times as strong as a 0.9% solution. Since a 0.9% solution is isotonic and isosmotic with body fluids, a normal chemical solution (5.85%) therefore is obviously damagingly hypertonic. When blood or other cells from tissues are placed in noninjurious aqueous solutions
TCT-122 Clinical Outcome in Patients Undergoing Surgical or Percutaneous Revascularization Associated to Valve Surgery
Authors: Alessandro Lualdi, Giovanni Teruzzi, Dario Pellegrini, Luca Grancini, Alessia Dalla Cia, Stefano Salis, Stefano Galli, Paolo M. Ravagnani, Daniela Trabattoni, Piero Montorsi, Antonio L. Bartorelli
Journal: Journal of the American College of Cardiology (2014)
Changing from Imperial to Metric
Authors: W. H. Spoor
Journal: BMJ (1964)

SIR,-We wish to support Dr. R. E. Smith's plea (14 March, p. 695) for a full adoption of the metric system as soon as possible, and especially his suggestion that we must abandon the past and not use the system in terms of more or less exact equivalents of the Imperial system.The 1963 editions of the British Pharmacopocia and British Pharmaceutical Codex 'both include notices stating that up to 30 June 1965 preparations in the old system may be supplied when metric or Imperial prescriptions or those without strengths are -presented.This is to allow timne for the disposal of old stocks.The time limit has now been extended to 31 July 1965 for manufacturers or wholesalers and 31 January 1966 for retailers.The General Notices of the Codex state that the Codex Revision Committee intended to reformulate all the preparations of the -Codex in rational metric terms, but it was found impossible to carry out all the necessary experimental work before the volume had to go to press.It was therefore decided that the 1963 Codex reformulation should confine this to certain solid unit dosage forms, such as lozenges, pastilles, pessaries, suppositories, and tablets.The remaining preparations will be altered in the next edition (due in 1968).Liquid formulae containing new products have, however, been formulated in rational metric quantities.This results in some linctuses, for example, being made up to a 5 ml.dose and others to a 60 minim (4 ml.) dose.The anomalies will be removed in the -next edition.This delay is unfortunate since it will prolong the confusion.As we pointed out in this journal in 1953,1 the change means a certain amount of hard- ship to those who have to alter their prescribing habits, but the eventual result will justify it.This hospital changed completely to the metric system on 1 January 1957 after two years' notice had been given, and the change -went smoothly with no serious difficulties.2A U.C.H. sister stated that " getting accustomed to the metric system was like learning a new language, and learning to think in this new language took time and effort," but she concluded that once the effort had been made " the advantage of the metric system as far as the nursing staff is con- cerned is that it is more simple and, therefore, safer."' We consider it is best to change as soon as possible to rational quantities based on 50 mg.instead of 60.As one of us has
Medical experts and the criminal courts
Authors: J. A M Gall
Journal: BMJ (2003)

Editor—Although I agree with Milroy, I think it unfortunate that he did not extend his editorial to propose a system for the auditing and assessment of quality in medicolegal work.1 Experience shows that meaningful audit could be very difficult to attain for many reasons that include the following five.

The first is the legal system. The adversarial system is simply one of winning and not one of finding the truth. This encourages the use of “hired guns” and brings pressure on experts from both sides to provide “favourable” reports in the interests of maintaining client satisfaction and obtaining further medicolegal work.

The second is the absence of evidence based forensic medicine. Properly conducted research in the field has been comparatively limited and many of the forensic “facts” are neither supported by nor based on controlled research findings but on published personal views.

The third is personalities and titles. Personality conflicts and favouritisms can interfere in the objective assessment of performance and the establishment of a list of accredited “experts.” Titles are a problem as professorial and associate professorial appointments are not always indicators of either knowledge or competence, although are often viewed as such, particularly in the courts.

The fourth is representation. People who provide medicolegal services are associated with a wide variety of learned societies and colleges. Most do not have effective audit systems in place, and even if they did, no uniform standard exists across all fields.

The last is assessment of court performance. Court presentation is an important aspect for any medicolegal practitioner but can this be objectively and inexpensively assessed?

Audit and quality assurance programmes are certainly necessary and are long overdue but the implementation of an objective system free from bias could be very difficult. Many changes are needed including consideration of both national and international governing bodies that are inclusive of all medicolegal practitioners.
Identification of citrullinated fibrinogen peptides as T cell epitopes in humanised HLA-DR4 transgenic mice
Authors: J. van Heemst, A. Feitsma, E. van der Voort, R. Toes, A. Ioan-Facsinay
Journal: Annals of the Rheumatic Diseases (2011)

<h3>Background</h3> Antibodies directed against citrullinated proteins (ACPAs) are highly specific for rheumatoid arthritis (RA). The production of ACPAs is most likely dependent on the presence of T cells, since ACPAs undergo isotype switching and are associated with the shared epitope–containing HLA-DRB1 alleles. Fibrinogen is a likely candidate protein for T cell recognition, since a large subset of patients is positive for ACPAs that are reactive with (peptides derived from) citrullinated fibrinogen. <h3>Objectives</h3> The aim of this study was to identify citrullinated fibrinogen peptides that are presented to HLA-DRB1*0401-restricted T cells. <h3>Methods</h3> HLA-DR4-transgenic mice were immunised with citrullinated fibrinogen and T cell proliferation against all possible citrullinated fibrinogen peptides derived from the α, β, γ chain was analysed. <h3>Results</h3> T cell reactivity against several different citrullinated fibrinogen peptides was observed. <h3>Discussion</h3> Ongoing research is aimed at determining whether these responses are citrulline-specific and whether there is reactivity against the identified citrullinated peptides in PBMCs of RA patients.
Publish and perish: how plagiarism can penalize perpetrators
Authors: A. Anstey
Journal: British Journal of Dermatology (2015)

We should ignore whining about the supposedly awful pressures of ‘publish or perish’ when we have little credible evidence on what motivates misconduct, or on what motivates the conduct of honest, equally stressed colleagues. Laziness, desire for fame, greed and an inability to distinguish right from wrong are just as likely to be at the root of the problem.1 Academic authors have a moral obligation to credit others accurately and fully for their work. Imagine my surprise at being alerted to four separate episodes of apparent plagiarism in papers currently undergoing peer review in the BJD. How could this happen? The reasons are complex, but not altogether surprising. Before analysing this, let us consider the context. In 2005, Martinson et al.2 published an overview of what research misconduct is generally accepted to be. They described how such misconduct manifests and estimated its extent. In the same year, a common definition of research misconduct was reissued by the U.S. Department of Health and Human Services, with plagiarism defined as follows: ‘Plagiarism is the appropriation of another person's ideas, processes, results, or words without giving appropriate credit’. They went on to note that, ‘Research misconduct does not include honest error or differences of opinion’.3
Fatal complications of endoscopic ultrasonography: a look at 18 cases
Authors: J. Lachter
Journal: Endoscopy (2007)

Endoscopic ultrasonography (EUS) is perceived and reported to be a very safe procedure, at least in expert hands. Biennial assessment of all EUS procedures done in Israel since 1999 shows 8 cases of fatal EUS complications out of a total of 20 000 procedures. In seven of the eight cases tears of the duodenum were involved (all occurring with linear-type echoendoscopes); none involved fine-needle aspiration biopsy (FNA). Duodenal diverticuli were noted in four of the eight cases. Limited experience with linear echoendoscopes on the part of the operator (around 100 procedures or fewer) was common (five of the eight cases).
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone
Authors: Omar M E Albagha, Micaela R Visconti, Nerea Alonso, Anne L Langston, Tim Cundy, Rosemary Dargie, Malcolm G Dunlop, William D Fraser, Michael J Hooper, Gianluca Isaia, Geoff C Nicholson, Javier del Pino Montes, Rogelio Gonzalez-Sarmiento, Marco di Stefano, Albert Tenesa, John P Walsh, Stuart H Ralston
Journal: Nature Genetics (2010)