Penicillin Hypersensitivity in Patients with Bacterial Endocarditis
Authors: MICHAEL H. GRIECO
Journal: Annals of Internal Medicine (1964)

Article1 February 1964Penicillin Hypersensitivity in Patients with Bacterial EndocarditisMICHAEL H. GRIECO, M.D., MICHAEL R. DUBIN, M.D., JOHN L. ROBINSON, M.D., MILES J. SCHWARTZ, M.D., F.A.C.P.MICHAEL H. GRIECO, M.D.Search for more papers by this author, MICHAEL R. DUBIN, M.D.Search for more papers by this author, JOHN L. ROBINSON, M.D.Search for more papers by this author, MILES J. SCHWARTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-204 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince its discovery, penicillin has remained the antibiotic of choice for the treatment of bacterial endocarditis. This disorder requires therapy with bacteriocidal agents, for the literature is replete with reports of the inefficiency of bacteriostatic drugs (1). Thus the physician who must manage a penicillin-sensitive patient afflicted with bacterial endocarditis is faced with a major dilemma. In our experience this problem is not infrequent.The treatment of bacterial endocarditis in patients allergic to penicillin receives only superficial mention in the medical literature. Some articles propose solutions to this problem, which are wholly inaccurate. Others reflect a basic misunderstanding of penicillin...References1. FINLAND M: Current status of therapy in bacterial endocarditis. JAMA 166: 364, 1958. CrossrefMedlineGoogle Scholar2. RAFFEL S: Immunity, 2nd ed., Appleton-Century-Cross, Inc., New York, 1961, p. 279. Google Scholar3. SIEGAL S: Allergic reactions to antibiotics. New York J. Med. 55: 2303, 1955. MedlineGoogle Scholar4. GUTHEIDSÖEWILLCOX TORR: Untoward penicillin reactions. Bull. WHO 19: 427, 1958. MedlineGoogle Scholar5. WILENSKY AO: Fatal delayed anaphylactic shock after penicillin. JAMA 131: 1384, 1946. 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Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Department of Medicine, St. Luke's Hospital, New York, N. Y.Requests for reprints should be addressed to Miles J. Schwartz, M.D., 102 East 81st Street, New York 28, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnaphylaxis and Anaphylactic ShockPenicillin AllergyAllergic Reactions to DrugsDrug allergy—Problems and strategiesPrevention and Treatment of Drug AllergiesSynergism of Cefazolin-Gentamicin Against EnterococciPenicillin Desensitization — A Case ReviewDrug AllergyBacterial endocarditis in regularly dialyzed patientsPOSSIBLE ADVANTAGES OF HIGHLY PURIFIED PENICILLIN IN AVOIDING PENICILLOYL-SPECIFIC SENSITIZATION AND ALLERGIC REACTIONS.SPECIFIC HYPOSENSITIZATION OF PATIENTS WITH PENICILLIN ALLERGYTreatment of Bacterial Endocarditis in Patients with Penicillin HypersensitivityGEORGE R. GREEN, M.D., GUSTAVUS A. PETERS, M.D., F.A.C.P., JOSEPH E. GERACI, M.D., F.A.C.P.Antimicrobial therapy in patients sensitive to penicillinMixed septicemias and gastrointestinal diseaseKinetics of Reactions Involved in Penicillin Allergy ITreatment of Bacterial Endocarditis with Cephalosporin Derivatives in Penicillin-Allergic PatientsInfective Endocarditis in the Antibiotic EraUse of Steroids in Penicillin-Sensitive Patients with Bacterial Endocarditis 1 February 1964Volume 60, Issue 2_Part_1Page: 204-216KeywordsAllergy and immunologyAnaphylaxisAntibioticsDrug therapyEndocarditisHospital medicineHypersensitivityPenicillinStreptococcus Issue Published: 1 February 1964 PDF downloadLoading ...