THE TREATMENT OF ANGINA PECTORIS WITH KHELLIN*
Authors: JAMES J. CONN
Journal: Annals of Internal Medicine (1952)

Article1 May 1952THE TREATMENT OF ANGINA PECTORIS WITH KHELLINPart IJAMES J. CONN, M.D., R. W. KISSANE, M.D., F.A.C.P., RUTH A. KOONS, M.D., F.A.C.P., THOMAS E. CLARK, M.D.JAMES J. CONN, M.D.Search for more papers by this author, R. W. KISSANE, M.D., F.A.C.P.Search for more papers by this author, RUTH A. KOONS, M.D., F.A.C.P.Search for more papers by this author, THOMAS E. CLARK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1173 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe potent vasodilator action of khellin,†officially named visammin,1has been demonstrated in many pharmacologic laboratories by means of the heart-lung preparation and other technics during the past two decades. Among the earlier studies were those carried out by Fahmy,2Samaan3and Spaeth and Gruber,4while more recently Anrep, Barsoum and Kenawy5, 6, 7have proved that khellin has a more powerful action than many of the coronary vasodilators commonly employed. Toxicity studies in animals have not been numerous, but Samaan3found that the lethal dose in toads and rabbits was many times greater than the therapeutic dose, and the...Bibliography1. Council on Pharmacy and Chemistry. Report: Visammin as generic designation for dimethoxy-methyl-furano-chromome, J. A. M. A. 141: 26, 1949. Google Scholar2. FahmyEl Keiy IRMA: Ammi visnaga, Report Pharmacol. Soc. Cairo 3: 36, 1931. Google Scholar3. Samaan K: The pharmacological action of visammin, Quart. J. Pharm. and Pharmacol. 5: 6, 1932. Google Scholar4. SpaethGruber EW: Die Konstitution des Kellins (aus Ammi visnaga), Ber. d. deutsch. chem. Gesellsch. 71: 106, 1938. CrossrefGoogle Scholar5. AnrepBarsoumKenawy GVGSMR: The pharmacological actions of the crystalline principles of Ammi visnaga Linn, J. Pharm. and Pharmacol. 1: 164, 1949. CrossrefMedlineGoogle Scholar6. AnrepKenawyBarsoumFahmy GVMRGSAR: The biological action of the crystalline principles of Ammi visnaga , Gaz. Faculty Med. Cairo 14: 1, 1947. Google Scholar7. BarsoumKenawyEl-Sheehy GSMRA: Absorption of khellin and its estimation in blood and tissues, J. Roy. Egyptian M. A. 30: 312, 1947. MedlineGoogle Scholar8. ConnClarkKissane JJTERW: Toxicity study of khellin, Arch. Med. de San Lor. 1: 465, 1950. Google Scholar9. AnrepBarsoumKenawyMisrahy GVGSMRG: Ammi visnaga in the treatment of the anginal syndrome, Brit. Heart J. 8: 171, 1946. CrossrefGoogle Scholar10. KenawyBarsoum MRGS: Ammi visnaga in the treatment of the anginal syndrome, Gaz. Faculty Med. Cairo 13: 39, 1945. Google Scholar11. AnrepKenawyBarsoum GVMRGS: The coronary vasodilator action of khellin, Am. Heart J. 37: 531, 1949. CrossrefMedlineGoogle Scholar12. ScottIglauerGreenKaufmanBermanMcGuire RCARSJWBJ: Studies on the effect of oral and parenteral administration of visammin (khellin) in patients with angina pectoris, Circulation 3: 80, 1951. CrossrefMedlineGoogle Scholar13. BestCoe MMWS: Effect of khellin on coronary artery insufficiency as evaluated by electrocardiographic tests, Circulation 2: 344, 1950. CrossrefMedlineGoogle Scholar14. RosenmanFishmanKaplanLevinKatz RHAPSRHGLN: Observations on the clinical use of visammin (khellin), J. A. M. A. 143: 160, 1950. CrossrefMedlineGoogle Scholar15. OsherKatz HLKH: Khellin in the treatment of angina pectoris, Boston M. Quart. 1: 11, 1950. Google Scholar16. Ayad H: Khellin in angina pectoris, Lancet 1: 305, 1948. CrossrefGoogle Scholar17. GreinerGold TH: A method for the evaluation of the effect of drugs on the cardiac pain of angina of effort: a study of khellin, J. Pharmacol. and Exper. Therap. 98: 10, 1950. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES J. CONN, M.D.; R. W. KISSANE, M.D., F.A.C.P.; RUTH A. KOONS, M.D., F.A.C.P.; THOMAS E. CLARK, M.D.Affiliations: Columbus, Ohio*Received for publication August 25, 1951.From the Cardiological Departments of the College of Medicine of the Ohio State University, and White Cross Hospital, Columbus, Ohio.†The khellin used in this study was in the form of 20 mg. coated tablets supplied by the National Drug Co., Philadelphia, Pa.‡100 mg. capsules of khellin supplied by the Warren-Teed Products Co., Columbus, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnginaKhellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a ]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1AnginaRecurrent Kidney StonesEffects of khellin and timefurone on secretion and catabolism of lipoproteins by cultured rabbit and human hepatocytesBibliographyDrug evaluation in angina pectoris: Khellin, heparin, PeritrateTreatment of Angina PectorisTHE TREATMENT OF ANGINA PECTORIS WITH KHELLIN*PART IIJAMES J. CONN, M.D., R. W. KISSANE, M.D., F.A.C.P., RUTH A. KOON, M.D., F.A.C.P., THOMAS E. CLARK, M.D. 1 May 1952Volume 36, Issue 5Page: 1173-1178KeywordsAnginaDrugsHospital medicineLethal doseRabbitsToxicityVasodilators ePublished: 1 December 2008 Issue Published: 1 May 1952 PDF downloadLoading ...