tbuckley/cabot-search huggingface dataset:
Somatically generated mouse myeloma variants synthesizing IgA half-molecules.
Authors: D J Zack, S L Morrison, W D Cook, W Dackowski, M D Scharff
Journal: The Journal of Experimental Medicine (1981)

Whereas mouse myelomas that secrete IgA half-molecules have been shown to arise in vivo, their origin has not been definitely established. We show that somatic variants secreting phenotypically similar molecules can arise directly from the normal IgA-secreting myelomas S107 and W3082. In addition to being improperly assembled, the variant proteins have distinct carboxy-terminal deletions and an aberrant heavy-light chain disulfide bond. For at least one of the variants, variable region serology and affinity for hapten are both unaffected by these changes. Southern and Northern blot analyses indicate normal size DNA restriction fragments and mRNA, suggesting premature termination as the mechanism of deletion. These results are discussed in relation to possible mutational hot spots and long-range interdomain interactions.
Long-Term Evaluation of Transurethral Needle Ablation of the Prostate (TUNA) for Treatment of Symptomatic Benign Prostatic Hyperplasia: Clinical Outcome up to Five Years from Three Centers
Authors: Alexandre R. Zlotta, Xenofon Giannakopoulos, Odd Maehlum, Tonnes Ostrem, Claude C. Schulman
Journal: European Urology (2003)
Thyroid Nodules and Needle Biopsy
Authors: J. MARTIN MILLER
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 November 1984Thyroid Nodules and Needle BiopsyJ. MARTIN MILLER, M.D., JOEL I. HAMBURGER, M.D., SUDHA R. KINI, M.D.J. MARTIN MILLER, M.D.Search for more papers by this author, JOEL I. HAMBURGER, M.D.Search for more papers by this author, SUDHA R. KINI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-718_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Gharib and associates (1) report that 333 of 1970 patients with thyroid nodules who were treated at the Mayo Clinic had "suspicious" findings on fine-needle aspiration biopsy. They advised surgical excision of all such lesions because 24% of 253 excised lesions were malignant. Comparison with the published experience with fine-needle aspiration biopsy or large-needle aspiration biopsy on our first 2000 patients shows important differences (2). Gharib and associates placed their nodules in three diagnostic categories: malignant, 5%; suspicious, 17%; and benign, 78%. We also had three categories: probably malignant, 15%; possibly malignant, 17%; and probably benign, 67%....References1. GHARIBGOELLNERZINSMEISTERGRANTVAN HEERDEN HJACJ. Fine-needle aspiration biopsy of the thyroid: the problem of suspicious cytologic findings. Ann Intern Med. 1984;101:25-8. LinkGoogle Scholar2. MILLERKINIHAMBURGER JSJ. Needle Biopsy of the Thyroid. New York: Praeger; 1983:168-86. Google Scholar3. MILLERKINIHAMBURGER JSJ. Fine needle aspiration cytology, or cutting biopsy, or both in the evaluation of solitary thyroid nodules? In: THOMPSON NW, VINIK AJ, eds. Endocrine Surgery; Update. New York: Grune & Stratton; 1983:23-37. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 4400 Prudential Town Center Southfield, MI 48075 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFine-Needle Aspiration of Thyroid Nodules: Past, Present, and FutureDiagnostic value of qualitative and quantitative variables in thyroid lesionsFine needle aspiration of thyroid nodules in a rural settingFine needle aspiration of the thyroid 1 November 1984Volume 101, Issue 5Page: 718-718KeywordsBiopsyLesionsThyroid Issue Published: 1 November 1984 PDF DownloadLoading ...
Ex-ministers to face trial in French "blood scandal"
Authors: Alexander Dorozynski
Journal: BMJ (1998)

The 225 page report released last week by three French magistrates who investigated the infection of hundreds of patients with blood or blood products contaminated with HIV reads like an indictment. For the first time in recent history, three former ministers will have to answer penal charges for alleged acts during their tenure.

According to the investigating judges, the three former ministers bear a grievous share of responsibility in the “contaminated blood affair,” which first surfaced in 1992. They will answer to charges of involuntary homicide and involuntarily compromising the well being …
TYPHOID IN A COMPANY OF IMMUNIZED SOLDIERS
Authors: SAMUEL BRADBURY
Journal: JAMA (1918)

The occurrence of four cases of typhoid fever in a company of 175 men (Company F, Eleventh Engineers, (Ry.), A. E. F.), who had been immunized but five months before the occurrence of the infection, is of enough interest to warrant a brief report. The available facts are not so complete and convincing as is desirable, especially as there is a bacteriologic discrepancy to be noted later. Despite this, it is hoped to emphasize the fact that, while an effort has been made to protect our soldiers from typhoid group infection by immunizing them, the six injections they received are not a guarantee that they will not contract one of these diseases. Some persons do not develop immunity, or retain it a very short time, as is known from the not unusual second attack of typhoid, and in any event no soldier should abuse his immunity. Most of the men
ABC of Breast Diseases: BREAST RECONSTRUCTION AFTER SURGERY
Authors: J D Watson, J R C Sainsbury, J M Dixon
Journal: BMJ (1995)

The purpose of the operation is to reconstruct a breast mound to produce breast symmetry.In centres that provide reconstruction there has been a consistent increase in demand, and up to half of patients offered immediate breast reconstruction take up this offer.There is no evidence that immediate reconstruction increases the rate of local or systemic relapse, and it reduces the psychological trauma of the change in body image experienced after mastectomy.Breast reconstruction (particularly immediate reconstruction, which gives substantially better cosmetic and psychological outcomes) should be more widely available than it is at present.
GPs are dissatisfied with the care they are giving patients with eating disorders
Authors: Jill Graham
Journal: BMJ (2005)

Few GPs adhere to primary care guidelines and protocols on the management of eating disorders, and many feel dissatisfied with the treatment they are providing, according to a British study presented at the seventh international eating disorders conference, held in London last week.

Researchers at the Institute of Psychiatry sent questionnaires to all GPs and university counsellors in south London, Surrey, Sussex, and Kent, who together serve a population of 6.4 million.

Half of the GPs who responded had had at least one new case of an eating disorder during the previous year. Overall, around a quarter of these patients were managed exclusively in primary care. However, individual GPs tended to refer either all or none of the affected patients, a practice that …
Insulin and Insulin-Like Growth Factor-1 Abnormalities in Antipsychotic-Naive Schizophrenia
Authors: Ganesan Venkatasubramanian, Seetharamaiah Chittiprol, Narendran Neelakantachar, Magadi N. Naveen, Jagadisha Thirthall, Bangalore N. Gangadhar, K. Taranath Shetty
Journal: American Journal of Psychiatry (2007)

Objective: The purpose of this study was to examine the evidence for the insulin-like growth factor-1 (IGF-1) deficiency hypothesis in the pathogenesis of schizophrenia. Method: The authors examined the fasting plasma levels of glucose, insulin, IGF-1, and cortisol in antipsychotic-naive schizophrenia patients (N=44) relative to age- and sex-matched healthy comparison subjects (N=44). Patients and comparison subjects were also matched for anthropometric measures and physical activity. Results: Schizophrenia patients had a significantly higher mean plasma insulin level as well as a significantly higher mean insulin resistance score relative to healthy comparison subjects. The mean plasma IGF-1 level was significantly lower in patients. IGF-1 levels had a significant negative correlation with plasma insulin levels. The total positive symptoms score as well as the hallucinations subscore had a significant inverse relationship with IGF-1 levels. Conclusions: Deficient IGF-1 might underlie insulin resistance in schizophrenia. The IGF-1 deficit in antipsychotic-naive schizophrenia patients and its significant correlation with psychopathology scores suggest that IGF-1 might be potentially involved in the pathogenesis of schizophrenia.
<i>JAMA</i>Theme Issue on Diabetes—Call for Papers
Authors: Anne R. Cappola, Edward Livingston
Journal: JAMA (2013)

To coincide with the American Diabetes Association Scientific Sessions in June 2014, JAMA will publish a theme issue on diabetes research. Our goals are to inform readers about the latest research in both type 1 and type 2 diabetes and to provide useful reviews of the current state of basic and clinical science underlying diabetes treatments. The World Health Organization estimates that 350 million people worldwide have diabetes.1 The international obesity epidemic has certainly accelerated the need to better understand the epidemiology, identification, and treatment of diabetes. We invitemanuscripts that address the identification and management of this complex chronic disease. We are especially interested in clinical trials of prevention, treatment, and delivery of care for people with diabetes. Care requirements and treatment goals for diabetes vary by age, and we welcome studies of patient populations of any and all ages, from children to the elderly. We recognize that diabetes is a global health problem, and we encourage submission of manuscripts that address aspects of diabetes thatmay be unique to a specific regional population, such as Asia or Africa. For example, a recent study indicated that approximately 114 million individuals in China have type 2 diabetes and an additional 493 million have prediabetes.2 A recent meta-analysis estimated a 5.7% prevalence rate of diabetes associated with impaired glucose tolerance among adults in sub-Saharan Africa.3 Bothof these studieshighlight theburdenofnoncommunicable diseases, especially diabetes, which is among the most common,withmore than 80%of the 3.4million annual deaths from diabetes occurring in lowand middle-income countries.4 We encourage authors to submit reports of original research, review articles, and Viewpoints for consideration for this theme issue. We are particularly interested in reports of randomized clinical trials that represent advances in the treatment of diabetes and interventions aimed at prevention. Authors who are interested in submitting a manuscript for the diabetes theme issue should indicate this in the cover letter accompanying their manuscript submission. Manuscripts received before January 15, 2014, will have the best chance of consideration for the theme issue. Exceptions may be granted for late-breaking randomized clinical trials to be presented at the American Diabetes Association Scientific Sessions. In these cases, we recommend that authors contact us as early as possible to discuss the trial and to allow coordination of timing of publication with the scientific presentation. We also welcome questions about this theme issue. Authors should consult the JAMA Instructions for Authors for guidelines on manuscript preparation and submission.5 Highquality manuscripts submitted to JAMA that are not of sufficiently high priority for publication in JAMA may be referred to another journal in The JAMA Network. We look forward to receivingyourmanuscripts for the2014 diabetes theme issue of JAMA.
ACCIDENTAL LACERATION OF SCALP WITH REMOVAL OF A PIECE OF PARIETAL BONE
Authors: W. E. Deuel
Journal: JAMA (1930)

A most unusual injury occurred as a result of an explosion, Jan. 27, 1930, in one of the large industrial plants of New Jersey. A workman was attending to his regular duties at 2 a. m. on this date which necessitated his being near a reducer. There is a large funnel on top of this through which material is emptied into the reducer to produce a chemical reaction. Whether the workman was in the act of filling the reducer or had finished when the explosion occurred has not been determined. However, he was found lying on the floor unconscious by his fellow workmen. When he was brought to the plant hospital it was found that he had a circular laceration of the scalp over the right parietal region which measured 12 cm. in diameter. It was a clean cut flap, the base of which measured 6 cm. (fig. 1). There
Abstract 1144: Overexpression of Tripartite Motif-containing 24 contributes to human epithelium cell carcinoma and correlates with poor prognosis of patient with local advanced head and neck squamous cell carcinoma
Authors: Yan Lu, Wei Cao, Zhibin Cui, Wantao Chen
Journal: Cancer Research (2012)

Abstract BACKGROUND: To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC), we performed a genome-wide survey and found that Tripartite motif-containing 24(TRIM24) was a gene that was markedly up-regulated in HNSCC. TRIM24 is a member of transcriptional intermediary factor 1 family, functions as a co-regulator that modulate transcriptional activities of several nuclear receptors, either positively or negatively. Here, we investigated the effects of TRIM24 on proliferation, invasion and apoptotic potential in HNSCC cell lines as well as its clinical significance in HNSCC. METHODS: The expressions of TRIM24 were examined through real-time PCR and western blot in 56 pairs of HNSCC and adjacent normal samples, as well as in 8 HNSCC cell lines and primary normal keratinocytes. Three TRIM24 high-expressed cell line were transfected with TRIM24 siRNA, then the proliferation, invasion and apoptotic potential was assessed by cell-counting kit-8, colony formation, matrigel invasion chambers and flow cytometry. In addition, the clinical implication of TRIM24 was investigated in another independent 91 locally advanced HNSCC by immunohistochemistry. RESULTS: TRIM24 mRNA expression were up-regulated remarkably in HNSCC samples and cell lines through real-time PCR. Correspondingly, elevated TRIM24 translation levels were found in 2 of 3 (67%) HNSCC tissues that were selected randomly from the 56 paired HNSCC tissues and 6 of 8 HNSCC cell lines using Western blot analysis. A significant reduction in cell proliferation and increase in population of apoptotic cells were observed in TRIM24 siRNA transfected cell lines in p53-dependent manner. Moreover, 55%(50/91) of HNSCC samples show high expression of TRIM24 by immunohistochemistry and survival analyses indicated a significant association between TRIM 24 high expression and a reduced overall survival in patients with locally advanced HNSCC (log rank test, P = 0.020). CONCLUSION: Our data indicated that overexpression of TRIM24 may play an important role in HNSCC tumorigenesis and serve as an independent prognostic predictor for patients with locally advanced HNSCC. ACKNOWLEDGMENTS: This study was supported by the National Natural Science Foundation of China (Grant No. 30973343), Projects of the Shanghai Science and Technology Committee (Grant No. 08JC1414400 and 10XD1402500) and the Shanghai Leading Academic Discipline Project (S30206). *Yan Lu and Wei Cao contributed equally to this work. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1144. doi:1538-7445.AM2012-1144
The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF
Authors: Hiroko Shibata, Yasuo Yoshioka, Yasuhiro Abe, Akiko Ohkawa, Tetsuya Nomura, Kyoko Minowa, Yohei Mukai, Shinsaku Nakagawa, Madoka Taniai, Tsunetaka Ohta, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi
Journal: Biomaterials (2009)
Lower Vital Capacity Is Associated With Diabetes but Not With Metabolic Syndrome in Nonobese Japanese Men
Authors: Eiji Oda, Ryu Kawai
Journal: Diabetes Care (2009)

Lower vital capacity has been reported to be a predictor of diabetes in Western countries (1–3) and has also been reported to be associated with diabetes and other metabolic risk factors in Japanese middle-aged men (4). However, there is no report on the relationship between lower vital capacity and metabolic syndrome or diabetes in nonobese subjects. We studied cross-sectional relationships among percent vital capacity (%VC) and diabetes and metabolic risk factors using medical checkup data from 2,079 men and 1,215 women who visited our Medical Checkup Center and gave signed informed consent between April and …
Reviews and Notes: Gastroenterology: Infections of the Gastrointestinal Tract
Authors: Andrew G. Plaut
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 July 1996Reviews and Notes: Gastroenterology: Infections of the Gastrointestinal TractAndrew G. Plaut, MDAndrew G. Plaut, MDTufts University School of Medicine, New England Medical Center, Boston, MA 02111Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-1-199607010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail MJ Blaser, PD Smith, JI Ravdin, HB Greenberg, and RL Guerrants; eds. 1610 pages. New York: Raven; 1995. $245.00. ISBN 0781702267. Order phone 800-772-2295.Approximately 150 authors involved both in the care of patients and research on gut infections have packed this single-volume text with information. The 97 chapters begin with a brief history of the field and then cover infections caused by viruses, bacteria, fungi, and metazoan and protozoan parasites; infections caused by unclassifiable microorganisms; and well-classified organisms whose role in infections is uncertain. There are chapters on epidemiology, the clinical laboratory in diagnosis, prophylaxis for surgery, radiology, endoscopy ... Author, Article, and Disclosure InformationAffiliations: Tufts University School of Medicine, New England Medical Center, Boston, MA 02111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1996Volume 125, Issue 1Page: 79KeywordsAntibioticsGastrointestinal infectionsGastrointestinal tractProtozoan infectionsProtozoansSchistosomiasisSurgeryToxinsTropical diseasesVaccines ePublished: 15 August 2000 Issue Published: 1 July 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pyrosequencing Analysis of EGFR and KRAS Mutations in EUS and EBUS-Derived Cytologic Samples of Adenocarcinomas of the Lung
Authors: Jos A. Stigt, Nils A. ´t Hart, Ageeth J. Knol, Steven M. Uil, Harry J.M. Groen
Journal: Journal of Thoracic Oncology (2013)
A Spectral Event
Authors: Robert E. Fishbein
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial Endocarditis on Calcification of the Mitral Anulus Fibrosus
Authors: JOHN W. BURNSIDE
Journal: Annals of Internal Medicine (1972)

The clinical and autopsy findings in seven patients with bacterial endocarditis superimposed on degenerative calcification of the anulus fibrosus of the mitral valve are described. The calcification, with resultant deformity of the mitral valve, probably predisposed these patients to infection. The endocarditis was unusual in its location at the base of the valve and in its extension into the calcified ring and adjacent myocardium. The infection involved the posterior mitral leaflet in six patients and the anterior leaflet in one. In all cases the involved leaflet was perforated by the sepsis. The nature of this infection makes it unlikely that it is curable with either antibiotics or cardiac surgery. It is strongly recommended that appropriate endocarditis antibiotic prophylaxis be accorded all elderly patients with calcification of the mitral anulus.
Possible Defect in the Bile Secretory Apparatus in Arteriohepatic Dysplasia (Alagille's Syndrome): A Review with Observations on the Ultrastructure of Liver
Authors: Pedro Valencia-Mayoral, James Weber, Ernest Cutz, Vernon D. Edwards, M. James Phillips
Journal: Hepatology (1984)

Ultrastructural observations on 12 liver biopsies from 10 patients with arteriohepatic dysplasia syndrome (Alagille's syndrome) are reported. The electron microscopic changes in the liver in this condition are different from those seen in other forms of chronic intra- and extrahepatic cholestasis. In particular, the bile canalicular and pericanalicular changes classically observed in cholestasis are infrequently seen. When compared with other forms of intrahepatic cholestasis including syndromes associated with paucity of intrahepatic bile ducts, the ultrastructural changes in Alagille's syndrome appear to be distinctive. Bile pigment retention is found in the cytoplasm especially in lysosomes and in vesicles of the outer convex face of the Golgi apparatus (cis-Golgi), but rarely in bile canaliculi or the immediate pericanalicular region. These results suggest a block in the Golgi apparatus or in the pericanalicular cytoplasm.