tbuckley/cabot-search huggingface dataset:
Adenocarcinoma of the Breast Metastatic to Malignant Lymphoma
Authors: Gerald L. Woolam
Journal: JAMA (1966)

MULTIPLE primary malignancies involving different tissues in a patient are no longer considered to be rare; they occurred in 2.3% of 36,547 surgical patients with cancer and in 8.1% of 2,902 necropsies of cancer patients in a study by Moertel and associates.<sup>1</sup>However, metastasis of a cancer to a second primary malignancy has been reported with decidedly less frequency. The case presented in this communication is, to our knowledge, the first documented and illustrated instance of carcinoma of the breast metastatic to malignant lymphoma. <h3>Report of a Case</h3> A 60-year-old housewife came to this clinic for a general examination in January 1965. She had known of an enlarging mass in her left breast for approximately one year but had deferred medical consultation because of fear of possible breast surgery. In 1956, an examination had demonstrated a small plaque at the 2-o'clock position in the left breast, but this had not
JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer
Authors: Shoji Yamamoto, Zhenhua Wu, Hege G. Russnes, Shinji Takagi, Guillermo Peluffo, Charles Vaske, Xi Zhao, Hans Kristian Moen Vollan, Reo Maruyama, Muhammad B. Ekram, Hanfei Sun, Jee Hyun Kim, Kristopher Carver, Mattia Zucca, Jianxing Feng, Vanessa Almendro, Marina Bessarabova, Oscar M. Rueda, Yuri Nikolsky, Carlos Caldas, X. Shirley Liu, Kornelia Polyak
Journal: Cancer Cell (2014)
Impaired uptake of conjugated bile acids and hepatitis b virus pres1‐binding in na+‐taurocholate cotransporting polypeptide knockout mice
Authors: Davor Slijepcevic, Christina Kaufman, Catharina G.K. Wichers, Eduardo H. Gilglioni, Florian A. Lempp, Suzanne Duijst, Dirk R. de Waart, Ronald P.J. Oude Elferink, Walter Mier, Bruno Stieger, Ulrich Beuers, Stephan Urban, Stan F.J. van de Graaf
Journal: Hepatology (2015)

The Na + ‐taurocholate cotransporting polypeptide (NTCP) mediates uptake of conjugated bile acids (BAs) and is localized at the basolateral membrane of hepatocytes. It has recently been recognized as the receptor mediating hepatocyte‐specific entry of hepatitis B virus and hepatitis delta virus. Myrcludex B, a peptide inhibitor of hepatitis B virus entry, is assumed to specifically target NTCP. Here, we investigated BA transport and Myrcludex B binding in the first Slc10a1 ‐knockout mouse model ( Slc10a1 encodes NTCP). Primary Slc10a1−/− hepatocytes showed absence of sodium‐dependent taurocholic acid uptake, whereas sodium‐independent taurocholic acid uptake was unchanged. In vivo , this was manifested as a decreased serum BA clearance in all knockout mice. In a subset of mice, NTCP deficiency resulted in markedly elevated total serum BA concentrations, mainly composed of conjugated BAs. The hypercholanemic phenotype was rapidly triggered by a diet supplemented with ursodeoxycholic acid. Biliary BA output remained intact, while fecal BA excretion was reduced in hypercholanemic Slc10a1−/− mice, explained by increased Asbt and Ostα/β expression. These mice further showed reduced Asbt expression in the kidney and increased renal BA excretion. Hepatic uptake of conjugated BAs was potentially affected by down‐regulation of OATP1A1 and up‐regulation of OATP1A4. Furthermore, sodium‐dependent taurocholic acid uptake was inhibited by Myrcludex B in wild‐type hepatocytes, while Slc10a1−/− hepatocytes were insensitive to Myrcludex B. Finally, positron emission tomography showed a complete abrogation of hepatic binding of labeled Myrcludex B in Slc10a1‐/‐ mice. Conclusion: The Slc10a1 ‐knockout mouse model supports the central role of NTCP in hepatic uptake of conjugated BAs and hepatitis B virus preS1/Myrcludex B binding in vivo ; the NTCP‐independent hepatic BA uptake machinery maintains a (slower) enterohepatic circulation of BAs, although it is occasionally insufficient to clear BAs from the circulation. (H epatology 2015;62:207–219)
Scintigraphy of Kidneys Located at Different Depths: The Geometric Mean Method for Determination of Differential Renal Function
Authors: OLE J. HARTLING, JENS MARVING, OLE MUNCK
Journal: Clinical Nuclear Medicine (1987)

In patients with kidneys located at different depths, differential renal function cannot simply be determined with Tc-99m DMSA scintigraphy using the accumulated count rates from each kidney in the anteroposterior or posteroanterior projection. This will give grossly misleading results. In patients with abnormally located kidneys, scintigrams in both the anteroposterior and posteroanterior views may be obtained so that the geometrical mean method can be applied. An example of the use of this method is given.
Accuracy of Magnetic Resonance Imaging in Diagnosis of Liver Iron Overload: A Systematic Review and Meta-analysis
Authors: Maria Sarigianni, Aris Liakos, Efthymia Vlachaki, Paschalis Paschos, Eleni Athanasiadou, Victor M. Montori, Mohammad Hassan Murad, Apostolos Tsapas
Journal: Clinical Gastroenterology and Hepatology (2014)
NEUROLOGIC SIGNS AND THEIR DISCOVERERS
Authors: GEORGE W. HALL
Journal: JAMA (1930)

I have briefly reviewed some of the more common neurologic signs with the hope that, by including a history of their discovery, such signs may be more deeply impressed on the minds of those who are not so familiar with their significance and value as employed in their own specialty. The neurologists have been accused of using too freely the names of discoverers of these neurologic signs as a means of denoting organic change. Such names in themselves have no meaning as far as the underlying pathologic condition is concerned, and in the opinion of the general practitioner the method is much abused. In reply, one might say that such terms as the "acute abdomen" so frequently employed by the surgeons are also much abused and rather meaningless as far as expressing a diagnosis is concerned. <h3>ARGYLL ROBERTSON PUPIL</h3> Douglas Moray Cooper Lamb Argyll Robertson was born in Edinburgh in
Facilitation of calcium blocking and membrane effects by intrinsic sympathomimetic activity
Authors: H. J SMITH, S. E HALLIDAY, M. G BRISCOE, H M. SNOW
Journal: Cardiovascular Research (1984)

Journal Article Facilitation of calcium blocking and membrane effects by intrinsic sympathomimetic activity Get access HOWARD J SMITH, HOWARD J SMITH * From: ICI Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire *Address for reprint requests: Dr H J Smith, Clinical Research Department ICI Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire SK10 4TG. Search for other works by this author on: Oxford Academic PubMed Google Scholar SHARON E HALLIDAY, SHARON E HALLIDAY From: ICI Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire Search for other works by this author on: Oxford Academic PubMed Google Scholar MARTYN G BRISCOE, MARTYN G BRISCOE From: ICI Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire Search for other works by this author on: Oxford Academic PubMed Google Scholar H MICHAEL SNOW H MICHAEL SNOW From: ICI Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 1, January 1984, Pages 30–36, https://doi.org/10.1093/cvr/18.1.30 Published: 01 January 1984
Hemodynamic and radionuclide effects of acute captopril therapy for heart failure: changes in left and right ventricular volumes and function at rest and during exercise.
Authors: B Massie, B L Kramer, N Topic, S G Henderson
Journal: Circulation (1982)

Although the resting hemodynamic effects of captopril in congestive heart failure are known, little information is available about the hemodynamic response to captopril during exercise or about changes in noninvasive measurements of the size and function of both ventricles. In this study, 14 stable New York Heart Association class III patients were given 25 mg or oral captopril. Rest and exercise hemodynamic measurements and blood pool scintigrams were performed simultaneously before and 90 minutes after captopril. The radionuclide studies were analyzed for left and right ventricular end-diastolic volumes, end-systolic volumes, ejection fractions and pulmonary blood volume. The primary beneficial responses at rest were decreases in left and right ventricular end-diastolic volumes from 388 +/- 81 to 350 +/- 77 ml (p less than 0.01) and from 52 +/- 26 to 43 +/- 20 volume units (p less than 0.01), respectively, and in their corresponding filling pressures, from 24 +/- 10 to 17 +/- 9 mm Hg and 10 +/- 5 to 6 +/- 5 mm Hg (both p less than 0.001). Although stroke volume did not increase significantly, both left and right ventricular ejection fractions increased slightly, from 19 +/- 6% to 22 +/- 5% and from 25 +/- 9% to 29 +/- 11%, respectively (both p less than 0.01). During exercise, similar changes were noted in both hemodynamic and radionuclide indexes. Thus, in patients with moderate symptomatic limitation from chronic heart failure, captopril predominantly reduces ventricular volume and filling pressure, with a less significant effect on cardiac output. These effects persist during exercise, when systemic vascular resistance is already very low. Radionuclide techniques are valuable in assessing the drug effect in these subjects, particularly when ventricular volumes are also measured.
Update of the ACCORD Eye Study
Authors: Emily Y. Chew, Walter T. Ambrosius
Journal: New England Journal of Medicine (2011)

To the Editor: We wish to update our report on the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Eye study (July 15, 2010, issue).1 We made a mistake in the calculation of vision loss that also affected another article.2 Our intent was to define moderate vision loss as a 15-letter decrease on the visual acuity score from baseline in either eye. However, in the analyses described in the published reports,1,2 this calculation was erroneously made on the basis of the right eye only, resulting in fewer events as well as fewer people in whom a change in visual . . .
Immunologic Abnormalities in Wegener's Granulomatosis
Authors: K. ANDRASSY
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 July 1983Immunologic Abnormalities in Wegener's GranulomatosisK. ANDRASSY, G. DARAI, J. KODERISCH, E. RITZK. ANDRASSYSearch for more papers by this author, G. DARAISearch for more papers by this author, J. KODERISCHSearch for more papers by this author, E. RITZSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-1-127_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article by Fauci and associates (1) on Wegener's granulomatosis. We feel it is paradoxical that despite the known responsiveness to cyclophosphamide, immunohistologic and serologic evidence for immune abnormalities is scarce in this disease. We have recently seen four consecutive patients with Wegener's granulomatosis in whom antibodies against SSA (RO) were consistently shown during the active stage of the disease.A 55-year old man had a 5-week history of pneumonia and arthralgia; on admission he had fever, renal insufficiency, nephritic sediment, several nodular cavitating pulmonary infiltrates, and oro-nasal ulcers. Renal biopsy showed extracapillary...References1. FAUCIHAYNESKATZWOLFF ABPS. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98:76-85. LinkGoogle Scholar2. ALSPAUGHTAN ME. Antibodies to cellular antigens in Sjögren's syndrome. J Clin Invest. 1975;55:1067-73. CrossrefMedlineGoogle Scholar3. ALSPAUGHMADDISON MP. Resolution of the identity of certain antigen-antibody systems in systemic lupus erythematosus and Sjögren's syndrome: an interlaboratory collaboration. Arthritis Rheum. 1979;22:796-8. CrossrefMedlineGoogle Scholar4. HENDRICKWOLINRINKELERNERSTEITZ JSJMJ. RO SC RNP are a subclass LA RNP: further characterisation of the RO and La small ribonucleoproteins from uninfected mammalian cells. Mol Cell Biol. 1981;1:1138-49. CrossrefMedlineGoogle Scholar5. HARDINRAHNSHEN JDC. Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles. J Clin Invest. 1982;70:141-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medizinische Universitätsklinik und Institut für Virologie der Universität Heidelberg Heidelberg West Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySICCA SYNDROME IN PATIENTS WITH WEGENER'S GRANULOMATOSIS 1 July 1983Volume 99, Issue 1Page: 127-128KeywordsAntibodiesArthralgiaBiopsyCyclophosphamideFeversPneumoniaUlcersWegener granulomatosis Issue Published: 1 July 1983 PDF DownloadLoading ...
Evaluating new surgical procedures
Authors: I. Russell
Journal: BMJ (1995)

Surgery has been slow to take up the challenge of British epidemiologist Archie Cochrane: to prevent the introduction of new therapeutic procedures until randomised trials have shown them to be more effective than existing treatments.1 For example, laparoscopic cholecystectomy was first performed in 1987 and became the standard treatment for symptomatic gall stones within about seven years. During this period no more than 10 trials comparing laparoscopic with conventional forms of cholecystectomy were published worldwide. Of three peer reviewed randomised trials comparing laparoscopic and minilaparotomy cholecystectomy published in Britain since 1992,2 3 4 only one randomised more than 100 patients,5 justified this with a calculation of sample size, and analysed the results by intention to treat.6

Many potential problems have been cited to explain the shortage of rigorous surgical trials.7 Some are practical--for example, recruiting patients may be difficult. This problem can be resolved …
Abdominal Sections Performed during 1883
Authors: T. Savage
Journal: BMJ (1884)

3Z!MTI, ?I3WICaL J-O'U-lA (43 of a cakitts-is near the h]ddef; or so far id'w/ the ureter as tobe quite away fomith1p6sesibility of dislodgment.'.' ' SurgeOn to the Birmingham 'ospital fo Wotnme. .'ci f 4 i .l't hI.2
POST-OPERATIVE HEMORRHAGE.
Authors: A. H. CORDIER
Journal: JAMA (1901)

I know of no condition in my work that is more horrifying than to realize that a patient upon whom I have just performed an abdominal operation is bleeding dangerously. I know of no condition under which the surgeon will more quickly realize the importance of his work and appreciate more fully the great responsibility existing in every abdominal operation. An avoidable accident to a patient that may result in the death of that patient is a very serious matter and should not be passed over as a trifling affair by the surgeon. Trying to give contentment to the sorrowing family and friends by assuring them that the all-wise Providence willed it thus may satisfy the unsuspecting and confiding family circle; but does it relieve the mind of the surgeon or save the patient? The use of unstable ligature material on large pedicles and in localities where the same is
Coupled complementation of immune response genes controlling responsiveness to the H-2.2 alloantigen.
Authors: M E Dorf, J H Stimpfling
Journal: The Journal of Experimental Medicine (1977)

The ability of various B10 congenic resistant strains to respond to the alloantigen H-2.2 was tested. High and low antibody-producing strains were distinguished by their anti-H-2.2 hemagglutinating respones. However, these strains do not differ in their ability to respond to these antigenic differences in the mixed lymphocyte culture. The humoral response to the H-2.2 alloantigen was shown to be controlled by two interacting genes localized within the H-2 complex. Thus, F1 hybrids prepared between parental low responder strains could yield high level immune responses. In addition, strains bearing recombinant H-2 haplotypes were used to map the two distinct genes controlling the immune response. The alleles at each locus were shown to be highly polymorphic as evidenced by the asymmetric complementation patterns observed. The restricted interactions of specific alleles was termed coupled complementation. The significance of the results in the terms of mechanisms of Ir gene control are discussed.
Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-α expression
Authors: Michelina Nascimbeni, Leïla Perié, Laurent Chorro, Seckou Diocou, Louis Kreitmann, Stéphanie Louis, Laurent Garderet, Bettina Fabiani, Anne Berger, Jürgen Schmitz, Jean-Pierre Marie, Thierry Jo Molina, Jérôme Pacanowski, Jean-Paul Viard, Eric Oksenhendler, Stéphanie Beq, Orly Abehsira-Amar, Rémi Cheynier, Anne Hosmalin
Journal: Blood (2009)
In vitro factor VIII recovery during the delivery of ultra-pure factor VIII concentrate by continuous infusion
Authors: Donna M. DiMichele, Martin E. Lasak, Connie H. Miller
Journal: American Journal of Hematology (1996)

Factor VIII (FVIII) replacement by continuous infusion has been advocated as a cost-effective method for maintaining stable plasma levels of FVIII in the hemophilia A patients during surgery or life-threatening hemorrhage. Continuous delivery of monoclonal or recombinant FVIII concentrates to our pediatric patients using a traditional delivery system (dilution in normal saline of 2-10 U/ml infused at a rate of 20 ml/hr) has frequently yielded higher than expected factor usage to achieve desired levels and unexpected variability in plasma levels under presumed steady-state conditions. To determine if diminished in vitro FVIII recovery was responsible for these observations, a study of four ultrapure concentrates during 8 hr of in vitro continuous delivery was performed using four delivery systems. When reconstituted concentrate was added to normal saline in polyvinylchloride bags at a concentration of 10 U/ml (method IA), monoclonal products showed a stable recovery of 84-109% of time 0 levels. Recombinant product recovery dropped to 57-76% of time 0 levels before reapproximating the time 0 level at 2 hr. The addition of 10 mg/ml human albumin to the bags (method IB) did not improve recoveries. When reconstituted concentrate was delivered undiluted (method IIA), the early drop in recombinant recovery was eliminated; stable recovery of 78-117% of time 0 level was achieved with all products. In using method IA, a large discrepancy was seen between the actual time 0 recoveries and those expected based on vial assays, most striking for recombinant products (49-57% of expected. Method IIA allowed 75-90% recovery; addition of 20 mg/ml albumin of reconstituted but undiluted concentrate (method IIB) maximized recovery at 85-98% of expected.
The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats
Authors: Hiroshi Kajiwara, Takayoshi Yamaza, Masao Yoshinari, Tetsuya Goto, Shinji Iyama, Ikiru Atsuta, Mizuho A Kido, Teruo Tanaka
Journal: Biomaterials (2004)
Investigation of mycobacteria in Crohn's disease tissue by Southern blotting and DNA hybridisation with cloned mycobacterial genomic DNA probes from a Crohn's disease isolated mycobacteria.
Authors: P D Butcher, J J McFadden, J Hermon-Taylor
Journal: Gut (1988)

A mycobacterial aetiology for Crohn's disease (CD) has been suggested. Slow growing mycobacteria indistinguishable from M paratuberculosis, the causative agent of enteritis in ruminants (Johne's disease) have been isolated from CD tissues. We have used cloned genomic DNA probes derived from a CD isolated mycobacteria strain Ben, to investigate the presence of mycobacterial DNA sequences in CD tissues. DNA was extracted from total tissue from 17 CD and four control gut specimens. DNA was digested with restriction endonucleases, electrophoresed and transferred to nylon membranes by Southern blotting and hybridised to radiolabelled DNA probes. No mycobacterial DNA was detected in any tissue sample studied. Reconstitution experiments with known numbers of in vitro cultured mycobacteria showed sensitive detection of mycobacterial DNA. DNA extracted from mouse liver, infected with M lepraemurium revealed a strong hybridisation signal and showed the applicability of the experimental approach to the detection of mycobacterial DNA in naturally infected tissues. The results do not provide evidence for the involvement of mycobacteria in the pathogenesis of CD but do not exclude the possibility of low levels of infection in subsets of intestinal cells with spheroplast or cell wall deficient forms of mycobacteria.
Commentary: The obituary of general surgery?
Authors: R Greenhalgh
Journal: BMJ (1994)

Good organisation of vascular surgical services need not be accompanied by the emergence of vascular surgery as a separate specialty, but J A Michaels and colleagues are right to point to the need for change. Patients referred to a surgeon by their general practitioner often ask the surgeon whether he or she is a specialist in their problem. By the next century no patient will wish to be sent to a general surgeon. The obituary of general surgery is in view.

Vascular surgery is a good example of these trends, and so the main thrust of the comments of Michaels and colleagues should be supported. Patients can indeed expect emergencies to be managed by expertly trained vascular surgeons doing elective vascular surgery during the day, and patients must have proper access to the necessary skills. The current requirement …
Cardiac arrest associated with bone cement.
Authors: J N Powell, P J McGrath, S K Lahiri, P Hill
Journal: BMJ (1970)

Two cases of cardiac arrest during the operative replacement of a femoral head with a Thompson prosthesis are reported. CASE 1An 81-year-old woman was admitted to hospital with a subcapital fracture of the left femur.She was febrile (100.5'F.; 38-10 C.) and had cardiomegaly and signs of congestive failure.Blood pressure was 150/90 mm.Hg.She had glycosuria and a fasting blood sugar of 160 mg./100 ml.On bed rest, Russell