tbuckley/cabot-search huggingface dataset:
Androgens Up-regulate the Insulin-like Growth Factor-I Receptor in Prostate Cancer Cells
Authors: Giuseppe Pandini, Rossana Mineo, Francesco Frasca, Charles T. Roberts, Marco Marcelli, Riccardo Vigneri, Antonino Belfiore
Journal: Cancer Research (2005)

In this study, we show that androgens up-regulate insulin-like growth factor-I receptor (IGF-IR) expression and sensitize prostate cancer cells to the biological effects of IGF-I. Both dihydrotestosterone and the synthetic androgen R1881 induced an approximately 6-fold increase in IGF-IR expression in androgen receptor (AR)-positive prostate cancer cells LNCaP. In accordance with IGF-IR up-regulation, treatment with the nonmetabolizable androgen R1881 sensitized LNCaP cells to the mitogenic and motogenic effects of IGF-I, whereas an IGF-IR blocking antibody effectively inhibited these effects. By contrast, these androgens did not affect IGF-IR expression in AR-negative prostate cancer cells PC-3. Reintroduction of AR into PC-3 cells by stable transfection restored the androgen effect on IGF-IR up-regulation. R1881-induced IGF-IR up-regulation was partially inhibited by the AR antagonist Casodex (bicalutamide). Two other AR antagonists, cyproterone acetate and OH-flutamide, were much less effective. Androgen-induced IGF-IR up-regulation was not dependent on AR genomic activity, because two AR mutants, AR-C619Y and AR-C574R, devoid of DNA binding activity and transcriptional activity were still able to elicit IGF-IR up-regulation in HEK293 kidney cells in response to androgens. Moreover, androgen-induced IGF-IR up-regulation involves the activation of the Src-extracellular signal-regulated kinase pathway, because it was inhibited by both the Src inhibitor PP2 and the MEK-1 inhibitor PD98059. The present observations strongly suggest that AR activation may stimulate prostate cancer progression through the altered IGF-IR expression and IGF action. Anti-androgen therapy may be only partially effective, or almost ineffective, in blocking important biological effects of androgens, such as activation of the IGF system.
Treatment of Hyponatremia
Authors: Robert W. Schrier
Journal: New England Journal of Medicine (1985)

In 1978 Forrest et al.1 reported that demeclocycline was superior to lithium in the treatment of the chronic syndrome of inappropriate secretion of antidiuretic hormone. They studied 10 patients with the syndrome who had a mean serum sodium concentration of 122±4 mmol per liter in spite of severe water restriction. After 5 to 14 days of 600 to 1200 mg of demeclocycline, the mean serum sodium concentration in the 10 patients was 139±1 mmol per liter, with unrestricted water intake. In three patients, treatment with lithium was unsuccessful, and adverse central nervous system side effects developed in two of them. . . .
Pityriasis rubra pilaris in Indians
Authors: V.N. Sehgal, M.K. Jain, R.P. Mathur
Journal: British Journal of Dermatology (1989)

Journal Article Pityriasis rubra pilaris in Indians Get access V.N. Sehgal, V.N. Sehgal Departments of Dermatology and Venereology and *Pathology, Maulana Azad Medical College and Associated LNJPN and GB Pant Hospitals, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar M.K. Jain, M.K. Jain Departments of Dermatology and Venereology and *Pathology, Maulana Azad Medical College and Associated LNJPN and GB Pant Hospitals, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar R.P. Mathur R.P. Mathur Departments of Dermatology and Venereology and *Pathology, Maulana Azad Medical College and Associated LNJPN and GB Pant Hospitals, New Delhi, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 6, 1 December 1989, Pages 821–822, https://doi.org/10.1111/j.1365-2133.1989.tb08229.x Published: 01 December 1989
Clinical and Histopathologic Studies of Two Families with Lattice Corneal Dystrophy and Familial Systemic Amyloidosis (Meretoja Syndrome)
Authors: Tomy Starck, Kenneth R. Kenyon, Laila A. Hanninen, Charles Beyer-Machule, Richard Fabian, Robert A. Gorn, F. Dickinson McMullan, Jules Baum, Keith P.W.J. McAdam
Journal: Ophthalmology (1991)
Alcohol, Nutrient Intake, and Hypertension
Authors: Robert A. Holden
Journal: JAMA (1985)

To the Editor.—  In their report, Alcohol, Nutrient Intake, and Hypertension in US Adults, Gruchow et al 1 conclude that their results reaffirm the importance of sodium intake on blood pressure among US adults. This conclusion is open to criticism on two counts.  First, the authors do not make specific reference to any previous large general-population studies similar to theirs, the results of which they reaffirm. In fact, previous investigators endeavoring to find an association between sodium intake and blood pressure within large general-population groups have been unable to do so. 2-8   Second, the association between sodium intake and blood pressure found by the authors is so weak that it could as easily have been interpreted to reaffirm a lack of importance of sodium intake on blood pressure. Despite doing multiple comparisons, the authors used only P
Sarcoidosis, Liver Transplantation, and Cyclosporine
Authors: F. Adrian Casavilla
Journal: Annals of Internal Medicine (1993)

Letters1 December 1993Sarcoidosis, Liver Transplantation, and CyclosporineF. Adrian Casavilla, MD, David H. Van Thiel, MD, and Judith S. Gavaler, MDF. Adrian Casavilla, MDSearch for more papers by this author, David H. Van Thiel, MDSearch for more papers by this author, and Judith S. Gavaler, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-11-199312010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Cyclosporine inhibits T-helper cells, reduces interleukin-2 secretion and interleukin-2 receptor expression, and inhibits a wide range of inflammatory responses; T-helper cells and interleukin-2 are believed to be important in the pathogenesis of sarcoidosis.Our nine patients did well while receiving cyclosporine after liver transplantation. In contrast, in the patient described by Dr. Bain and colleagues, the disease was exacerbated. Although they suggest that immunosuppression may have participated in the reactivation of disease, their comment that post-transplant immunosuppression with cyclosporine and low-dose steroids was insufficient to prevent reactivation may be closer to the mark. Their report does not include ...References1. Cunnah D, Chew S, Wass J. Cyclosporin for central nervous system sarcoidosis. Am J Med. 1988; 85:580-1. Google Scholar2. York FL, Kovithavongs T, Man P, Rebuck AS, Sproule BJ. Cyclosporine and chronic sarcoidosis. Chest. 1990; 98:1026-7. Google Scholar Author, Article, and Disclosure InformationAuthors: F. Adrian Casavilla, MD; David H. Van Thiel, MD; Judith S. Gavaler, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRecurrent hepatic sarcoidosis following liver transplantation 1 December 1993Volume 119, Issue 11Page: 1148-1149KeywordsCellsLiver diseasesLiver transplantationNauseaPathogenesisQuality of lifeSarcoidosisSteroidsTransplantationVomiting ePublished: 15 August 2000 Issue Published: 1 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE OCCURRENCE OF SEASONAL VARIATIONS IN THE GOITER OF RABBITS PRODUCED BY FEEDING CABBAGE
Authors: Bruce Webster, David Marine, Anna Cipra
Journal: The Journal of Experimental Medicine (1931)

The evidence presented indicates that cabbage maturing in the spring and summer months has little goiter-produdag power. Cabbage maturing in the late autumn has much greater goiter-produdng power, although this shows considerable variation in different years. It has not been possible to correlate available meteorological data with these variations.
Simple Tests Are Often Best
Authors: William R. Barclay
Journal: JAMA (1981)

The introduction into medical practice of each new, and usually expensive, instrument, gadget, isotope, biochemical test, or drug is followed by a flurry of manuscripts being sent to medical editors. The authors usually include in their manuscript the much overused phrase "To the best of our knowledge, we are the first to report...." Receipt of such manuscripts generally drives the editor's spirits to a new low for the week. With pleasure we publish in this issue ofThe Journal(p 1682) quite a different type of report; the use of a simple, inexpensive, easy to use, and readily available instrument, the stethoscope, which if physicians will take the trouble to use it, provides a remarkably reliable clue to the diagnosis of peripheral vascular disease. Certainly, today, physicians are aided by a wondrous array of electronic and chemical marvels, but once in awhile we need reminding that application of the five
VASCULAR RESPONSE TO DRUG-ELUTING STENT IMPLANTATION IN A COMPLEX ATHEROSCLEROTIC PIG MODEL
Authors: Dhavalkumar B. Patel, Raul Llano, Dawn Winsor-Hines, Paul S. Seifert, Damir Hamamdzic, Martin G. Keane, Barbara A. Huibregtse, Robert L. Wilensky
Journal: Journal of the American College of Cardiology (2011)
International Perspectives on DSM-III
Authors: Paul Chodoff
Journal: JAMA (1984)

The core of this volume is a series of chapters, by invited contributors, describing regional and national psychiatric reactions to the third edition of the American Psychiatric Association's<i>Diagnostic and Statistical Manual of Mental Disorders (DSM-III)</i>. The responses make it clear that this system of psychiatric classification, sponsored by the American Psychiatric Association and used by American psychiatrists since 1980, has had an unexpectedly profound effect on psychiatrists throughout the world. This is one American export that clearly is not in the "ugly American" category! The chapter authors are well-known psychiatrists from all over the world, including not only countries in western Europe but also from Asia and the Third World. The critiques that they have produced are generally thoughtful and interesting. The overall tone is positive, although, as is to be expected, there is a considerable variation in degrees of approval. Possibly the most favorable assessment emanates from the
Correction: Error in Article on Airflow Obstruction
Authors: Israel Rubinstein
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 August 1990Correction: Error in Article on Airflow ObstructionIsrael Rubinstein, MDIsrael Rubinstein, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-4-334_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Our article had two typographic errors (1). The first was in the abstract underDesign. The sentence should have read, "Case-control study, using nonobese, age- and height-matched nonsmokers." The second error was in the second line of the legend to Figure 1. It should have read "V50 = forced expiratory volume at 50% of vital capacity."...Reference1. RubinsteinZamelDuBarryHoffstein INLV. Airflow limitation in morbidly obese, nonsmoking men. Ann Intern Med. 1990;112:828-32. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Nebraska Medical Center Omaha, NE 68198-2465 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHigh-Frequency Percussive Ventilation Rescue Therapy in Morbidly Obese Patients Failing Conventional Mechanical Ventilation 15 August 1990Volume 113, Issue 4Page: 334-334KeywordsForced expiratory volume Issue Published: 15 August 1990 PDF DownloadLoading ...
Hormones and Behavior: A Survey of Interrelationships between Endocrine Secretions and Patterns of Overt Response.
Authors: Frank A. Beach
Journal: Annals of Internal Medicine (1951)

Hormones and behavior: a survey of in terrelation ships between endocrine secretions and patterns of overt response , Hormones and behavior: a survey of in terrelation ships between endocrine secretions and patterns of... , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
The Destroying Angel: Sex, Fitness and Food in the Legacy of Degeneracy Theory, Graham Crackers, Kellogg's Corn Flakes and American Health History
Authors: Domeena C. Renshaw
Journal: JAMA (1985)

This is an interesting, erudite, carefully researched history of antisexualism in the United States during the 18th and 19th centuries. The author claims that in those years the degeneracy theory triggered an intense long-lasting campaign against masturbation, on the grounds that it was the cause of most of the ailments seen by physicians. He points out that while promoting sexual abstinence, a health-reform movement advocated temperance, vegetarianism (to eliminate carnal passion, allegedly resultant from eating flesh), and fitness through regular exercise. A proponent of this theory was Sylvester Graham, a popular speaker and an evangelist in the midst of an epidemic of cholera in 1830. He promoted harmonious health protection from cholera and many other diseases through the eating of his dried whole wheat bread (later modified and called "Graham crackers"). Although Graham later declined in popularity, his doctrine of sexual purity and exercise and his Graham bread diet was
AN INVESTIGATOR ON RESEARCH
Authors: William Allen Pusey
Journal: JAMA (1927)

<h3>To the Editor:</h3> —In<i>Science</i>, August 5, p. 117, Dr. R. E. Rose, head of the research department of the great DuPont Company, has a searching and provocative paper on research. It is not altogether orthodox. Indeed, his attitude must affect the orthodox believers in research "from cover to cover" a good deal as higher criticism does the fundamentalists. For Rose submits to careful scrutiny our tendencies in academic research; criticizes a great deal of it; thinks that it is unduly expensive, carelessly directed, unproductive as research and of doubtful value; and acts in general a good deal like an unbeliever in the Temple. It is a good deal like one of the talks of Dean Inge to the high churchmen. It is not that he is not a firm believer in the value of research, or that he does not recognize the value of knowledge for knowledge's sake and
ENHANCED INTERLEUKIN-1 ACTIVITY IN PLASMA OF PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE
Authors: Benjamin W. Van Tassell, Lucas Gambill, Ijeoma Okogbue, Stefano Toldo, Eleonora Mezzaroma, Ignacio M. Seropian, Roshanak Robati, Rosemary Rengel, Scott Midwall, Antonio Abbate
Journal: Journal of the American College of Cardiology (2011)
Ethacrynic Acid as Potential Drug for Diuretic Renography in Instance of Sulfonamide Allergy
Authors: Ba D. Nguyen, Michael C. Roarke, Osborn H. Howard
Journal: Clinical Nuclear Medicine (2010)

Furosemide is a sulfonamide derivative loop diuretic routinely used in the scintigraphic evaluation of obstructive uropathy. However, in the clinical context of severe allergy to sulfonamide antibiotics, it is prudent to avoid any potentially harmful cross-reaction with furosemide in renography. The authors present a case of alternative use of ethacrynic acid, a loop diuretic without sulfa moiety, which provides adequate and useful results in the assessment of the uretero-pelvic junction syndrome.
Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila
Authors: Emmanuel Perisse, Yan Yin, Andrew C. Lin, Suewei Lin, Wolf Huetteroth, Scott Waddell
Journal: Neuron (2013)

In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the αβ neurons, revealing a value-specific role for the ∼160 αβ core (αβc) neurons. Blocking neurotransmission from αβ surface (αβs) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking αβc only impaired appetitive memory. The αβc were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate αβc and αβs in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the αβ ensemble but only from the αβs for conditioned aversion.
Federal agencies vie with food habit surveys
Authors: Phil Gunby
Journal: JAMA (1980)

The federal government is becoming as interested as any local supermarket manager in the food-buying and eating habits of Americans. For example, the National Center for Health Statistics, Hyattsville, Md, is winding up its second Health and Nutrition Examination Survey (HANES II). Artemis P. Simopoulos, MD, chairman of the Nutrition Coordinating Committee at the National Institutes of Health, told the Western Hemisphere Nutrition Congress VI in Los Angeles recently that "HANES II will provide us with not only an update on health status but also the first look at change in the nutritional status of the population over time." At the same time, the US Department of Agriculture (USDA) has been making a survey of food consumption in low-income households. Betty B. Peterkin, a USDA supervisory home economist, told the Los Angeles conference: "The objectives of this year's survey are to show the effect on diets of inflation during the
INFLUENCE OF EARLY ADULT MODIFIABLE CARDIOVASCULAR RISK FACTORS ON LEFT ATRIAL INDEX: THE CARDIA STUDY
Authors: Anderson Armstrong, Samuel Gidding, Laura A. Colangelo, Satoru Kishi, Kiang Liu, Steven Sidney, Suma Konety, Cora Lewis, Luis Correia, Joao Lima
Journal: Journal of the American College of Cardiology (2012)
Up-regulation of Fas Ligand at Early Stages and Down-regulation of Fas at Progressed Stages of Intrahepatic Cholangiocarcinoma Reflect Evasion From Immune Surveillance
Authors: Tomonori Shimonishi, Kumiko Isse, Fumie Shibata, Isao Aburatani, Koichi Tsuneyama, Hemragul Sabit, Kenichi Harada, Kohji Miyazaki, Yasuni Nakanuma
Journal: Hepatology (2000)

We examined immunohistochemically the possible participation of the Fas/Fas ligand (FasL) system in intrahepatic cholangiocarcinoma (ICC) during the escape from immune surveillance, using 68 cases of ICC, 29 cases of normal intrahepatic large bile ducts, and 18 cases of biliary dysplasia. Apoptosis of tumor-infiltrating lymphocytes (TIL) was examined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL). Fas was weakly expressed in normal intrahepatic bile ducts. Almost all biliary dysplasia and well-differentiated ICCs showed moderate to marked expression of Fas, while Fas expression was variable in moderately and poorly differentiated ICCs. Down-regulation of Fas expression was significantly correlated with histologic de-differentiation, vascular invasion, the size of ICCs, and short survival of ICC patients. By in situ hybridization, FasL mRNA were frequently and strongly expressed in biliary dysplasia compared with non-neoplastic intrahepatic bile duct. In well-differentiated ICCs, FasL mRNA expression was frequent and intense. But, the expression gradually decreased in moderately and poorly differentiated ICCs. Down-regulation of FasL mRNA expression in ICCs was correlated with perineural invasion and tumor size (over 4 cm) ( P &lt; .05). Apoptotic TIL were more frequent in ICC foci than in non-neoplastic foci remote from ICC foci. These findings suggest that a tumor evasion mechanism involving Fas/FasL exists in ICC; frequent and intense expression of FasL mRNA in well-differentiated ICCs enable them to escape immune surveillance by counterattacking Fas-bearing TIL. This counterattack becomes insensitive in poorly differentiated ICCs, in which the down-regulation of Fas gives them a resistance against the FasL-expressing TIL. These mechanisms may be involved in the tumor progression.
Timothy Andrew Plunkett
Authors: Robert Rubens
Journal: BMJ (2005)

A pioneer of open heart surgeryBill Cleland was one of the surgeons who developed open heart surgery in London in the late 1950s.He was at Hammersmith Hospital in 1952-3 when Professor Dennis Melrose developed the first heart-lung machine.Melrose and Cleland conducted extensive animal tests before trying the machine in 1953 on patients whose prognosis was poor.In the early days there were postoperative deaths, which taught them the importance of meticulous postoperative care, and the clinical programme was restarted successfully in 1957.Cleland was one of the machine's earliest users, and it enabled him to perform a wide range of new operations, specialising in mitral valvotomy, the surgical treatment of ventricular septal defect, and aortic valve replacement.He was the first to operate on the newly identified condition of obstructive cardiomyopathy-known in the United States as hypertrophic subaortic stenosisby excising muscle from the interventricular septum via the aortic valve.Russian surgeons were impressed by Melrose's heart-lung machine, and Professor Aleksandr Bakulev from the then Soviet Union bought one; he then invited the Hammersmith team to operate in Moscow in May 1959.It was at the height of the cold war and they were the first foreign doctors to perform surgery there.Melrose, Cleland, and another surgeon, Hugh Bentall, went.The Russians chose two adults and four children with congenital heart defects.Two of them had Fallot's tetralogy, which Cleland and his colleagues had never operated on before.All six operations were successful.Cleland remarked that this was helped by God, who had so little to do in Russia that he was able to give the children his undivided attention.The trip was a success in other ways.Cleland took his cine camera and filmed the army parade in Red Square, and was astonished not to be arrested.The team then returned on the inaugural UK flight of the Tupolev 104, the Soviet Union's first jet powered passenger airliner.Cleland was a meticulous surgeon, possessed of great energy, and a great teacher.He was warm hearted, and remained calm in emergencies.He was
Laparoscopic Versus Open Nephroureterectomy for the Treatment of Upper Urinary Tract Urothelial Carcinoma: A Systematic Review and Cumulative Analysis of Comparative Studies
Authors: Shaobin Ni, Weiyang Tao, Qiyin Chen, Lianxin Liu, Hongchi Jiang, Hailong Hu, Ruifa Han, Chunyang Wang
Journal: European Urology (2012)
Synovial sarcoma of the sellar region
Authors: Bernd W. Scheithauer, Ana Isabel Silva, Keith Kattner, Jason Seibly, Andre M. Oliveira, Kalman Kovacs
Journal: Neuro-Oncology (2007)

Primary sarcomas of the sellar region are uncommon, although a wide variety have been reported. To date, no cases of primary synovial sarcoma have been described as occurring at this site. We report an immunohistochemically and molecular genetically confirmed primary synovial sarcoma involving the sellar/parasellar region and cavernous sinus in an adult male. Subtotal resection and radiosurgery proved to be efficacious. The spectrum of primary sellar region sarcomas is summarized.