tbuckley/cabot-search huggingface dataset:
Pyogenic cocci in infantile eczema throughout one year.
Authors: R J Smith, V G Alder, R P Warin
Journal: BMJ (1975)

To determine the source of pyococci causing attacks of sepsis in infantile eczema 20 patients with continuing eczema were followed up for one year, regular swabs being taken from the skin, nose, throat, and family contacts. The staphylococci were phage typed and the streptococci serologically typed. Staphylococci of the same phage type in most cases remained in reservoir sites on the skin and coincidently in the nose. Staphylococci causing attacks of clinical sepsis arose from these persistently colonized sites. Staphylococci of the same phage type were also common in family contacts. Streptococci of the same group in most cases did not remain on the skin. Streptococci causing attacks of clinical sepsis arose as new infections from external sources, sometimes from throat infections in the patient or family contacts. Strains of streptococci which are known to be associated with glomerulonephritis were isolated. It has been confirmed that staphylococci resistant to neomycin and sodium fusidate quickly emerge after the topical use of these antibiotics. Streptococci are highly resistant to neomycin and gentamicin, and moderately resistant to sodium fusidate, so the use of these antibiotics in topical steroid preparations will have little effect in preventing further attacks of clinical sepsis in these patients.
Autoimmune Hemolytic Anemia and Myasthenia Gravis Associated with Thymoma
Authors: Ira. C. Halperin, William F. Minogue, Zacharias D. Komninos
Journal: New England Journal of Medicine (1966)

NEOPLASMS of the thymus are associated with a wide spectrum of diseases, including myasthenia gravis,1 idiopathic acquired agammaglobulinemia,2 primary aregenerative anemia,3 Cushing's syndrome4 and systemic lupus erythematosus.5 In addition, there are 2 case reports of autoimmune hemolytic anemia and thymoma.6 , 7 The following case is the unique occurrence of both autoimmune hemolytic anemia and myasthenia gravis in a patient with a thymoma.Case ReportJ.B. 179545, a 62-year-old Armenian man, was admitted to St. Vincent's Hospital on February 14, 1964, complaining of weakness, double vision and slurred speech of 1 month's duration. Five months previously he had undergone a prostatectomy at . . .
A novel form of human STAT1 deficiency impairing early but not late responses to interferons
Authors: Xiao-Fei Kong, Michael Ciancanelli, Sami Al-Hajjar, Laia Alsina, Timothy Zumwalt, Jacinta Bustamante, Jacqueline Feinberg, Magali Audry, Carolina Prando, Vanessa Bryant, Alexandra Kreins, Dusan Bogunovic, Rabih Halwani, Xin-Xin Zhang, Laurent Abel, Damien Chaussabel, Saleh Al-Muhsen, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis
Journal: Blood (2010)
Maternal Glycemic Control and Hypoglycemia in Type 1 Diabetic Pregnancy
Authors: Elisabeth R. Mathiesen, Brendan Kinsley, Stephanie A. Amiel, Simon Heller, David McCance, Santiago Duran, Shannon Bellaire, Anne Raben
Journal: Diabetes Care (2007)

To assess the safety and efficacy of insulin aspart (IAsp) versus regular human insulin (HI) in basal-bolus therapy with NPH insulin in pregnant women with type 1 diabetes.Subjects (n = 322) who were pregnant or planning pregnancy were randomized to IAsp or HI as meal-time insulin in an open-label, parallel-group, multicenter study. Subjects had A1C < or =8% at confirmation of pregnancy. Insulin doses were titrated toward predefined glucose targets and A1C <6.5%. Outcomes assessed included risk of major maternal hypoglycemia, A1C, plasma glucose profiles, and maternal safety outcomes.Major hypoglycemia occurred at a rate of 1.4 vs. 2.1 episodes/year exposure with IAsp and HI, respectively (relative risk 0.720 [95% CI 0.36-1.46]). Risk of major/major nocturnal hypoglycemia was 52% (RR 0.48 [0.20-1.143]; P = NS) lower with IAsp compared with HI. A1C was comparable with human insulin in second (IAsp-HI -0.04 [-0.18 to 0.11]) and third (-0.08 [-0.23 to 0.06]) trimesters. A total of 80% of subjects achieved an A1C < or =6.5%. At the end of first and third trimesters, average postprandial plasma glucose increments were significantly lower with IAsp than HI (P = 0.003 and P = 0.044, respectively), as were mean plasma glucose levels 90 min after breakfast (P = 0.044 and P = 0.001, respectively). Maternal safety profiles and pregnancy outcomes were similar between treatments.IAsp is at least as safe and effective as HI when used in basal-bolus therapy with NPH insulin in pregnant women with type 1 diabetes and may potentially offer some benefits in terms of postprandial glucose control and preventing severe hypoglycemia.
Defibrinogenation after Intra-Amniotic Injection of Hypertonic Saline
Authors: Jerry L. Spivak, Donald B. Spangler, William R. Bell
Journal: New England Journal of Medicine (1972)

In one patient generalized hemorrhage associated with hypofibrinogenemia and elevated fibrinogen-fibrin degradation products occurred two hours after the intra-amniotic injection of hypertonic saline. Serial coagulation studies were then performed on 12 patients undergoing abortion by intra-amniotic injection of 20 per cent sodium chloride, and six patients during normal labor and delivery. During normal delivery there was only a slight elevation of fibrinogen-fibrin degradation products. After injection of hypertonic saline solution, fibrinogen and platelets decreased significantly, and fibrinogen-fibrin degradation products increased.
EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction
Authors: Joseph J. Lynch, Gary L. Stump, Audrey A. Wallace, Carla A. Painter, Justina M. Thomas, Sandra E. Kusma, Robert J. Gould, William Grossman
Journal: Journal of the American College of Cardiology (1999)
The Staphylococcus and the Newborn Child
Authors: V. D. Plueckhahn
Journal: BMJ (1961)

attractively painted community nurseries in which the air was kept moving by the coming and going of nursing and medical staff, by cots being made, babies being changed, and dirty linen being sorted.All these things greatly increased the ease of transmission of the ubiquitous staphylococcus (Table I).Many changes in the conduct of the maternity wing were adopted as a result of these surveys (Plueckhahn and Banks, 1961) and were effected, except for " room- ing-in," by May, 1957.Special " rooming-in " cots were purchased in June, 1958, and from this time the babies were removed from the central nurseries after the first 24 hours of life and then-entirely cared for by their mothers.The only exceptions were for medical reasons concerning either the mother or the baby, and these occurred in approximately 5°' of all deliveries.Incidence of Staphylococcal Disease in 1957-9 All babies born after April, 1957, were examined daily while in hospital for signs of staphylococcal disease.The incidence is shown in Table II.TABLE II.-Inifectioni Rate in Babies Grouped in Three-month
Bronchodilator delivery by metered-dose inhaler in mechanically ventilated COPD patients: influence of flow pattern
Authors: E. Mouloudi, G. Prinianakis, E Kondili, D Georgopoulos
Journal: European Respiratory Journal (2000)

AIMS--To determine the prevalence of Helicobacter pylori in five main nationality groups with gastric ulcer, duodenal ulcer, and non-ulcer dyspepsia; and to determine the histopathological types of gastritis and assess the graded variables of Helicobacter associated gastritis. METHODS--Gastric antral and corpus biopsy specimens from 437 patients were examined for the prevalence of H pylori, 337 of which were classified and graded histologically according to the Sydney system. RESULTS--The overall colonisation rate of H pylori was 90%, and there was no significant difference between groups of different ethnic origins. The colonisation rates were 99%, 89%, and 78% in patients with duodenal ulcer, non-ulcer dyspepsia, and gastric ulcer, respectively. Helicobacter associated gastritis was the most common form of chronic gastritis (87%). H pylori density was greater in the antrum than the body. Gastric atrophy in helicobacter associated gastritis was seen in 54% of the cases (43% grade I, 10% grade II, 1% grade III) and increased the older the patients. Atrophy of the corpus alone was very rare (1%). Atrophy and intestinal metaplasia were more prevalent in patients with gastric ulcer than duodenal ulcer. CONCLUSION--The colonisation rate of H pylori was similar in the five groups studied and was almost invariably present in gastric biopsy specimens in patients with duodenal ulcer. H pylori associated gastritis was the most common form of gastritis. Atrophy was mainly of low grade and increased the older the patient.
Letter: Drinking drivers and the law.
Authors: K Norcross
Journal: BMJ (1976)

brain damage and continued excessive drink- ing represents a particularly serious threat to the lives of other road users, and if we are to take this threat seriously the assessment of convicted drunken drivers with the Hal- stead-Reitan test battery and the EMI-Scanner deserves our careful consideration not only as a possible index of current disability but also as a possible prognostic guide.I hope shortly to produce a six-year followup of our series of 33 alcoholics which may tell us whether the likelihood of relapse is related to objective indices of the extent of brain damage.
NOVEL LOW-DOSE CONTRAST CARDIAC CT ANGIOGRAPHY FOR AORTIC VALVE ANULUS SIZING IN TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Molly C. Mack, Deepika Gopalakrishnan, Paul Grayburn, Alicia Avila, Marina Lovil, Isabel Chacon, James M. Rampoldi, A. Cecile Mahoney, Jill Fowler, Angela Riley, William T. Brinkman, David L. Brown, Michael J. Mack, Ambarish Gopal
Journal: Journal of the American College of Cardiology (2014)
Genetic Polymorphisms of Interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and Risk of Prostate Cancer
Authors: Dominique S. Michaud, Sarah E. Daugherty, Sonja I. Berndt, Elizabeth A. Platz, Meredith Yeager, E. David Crawford, Ann Hsing, Wen-Yi Huang, Richard B. Hayes
Journal: Cancer Research (2006)

Abstract Chronic intraprostatic inflammation is suspected to play a role in the pathogenesis of prostate cancer. Polymorphisms in cytokine genes can influence inflammation and immune response and may be related to the risk of prostate cancer. Four common single nucleotide polymorphisms (SNPs) in the genes encoding interleukin-1B (IL-1B), IL-6, and IL-8 were assessed in 503 prostate cancer cases and 652 controls, and three SNPs in IL-10 were assessed in an additional 817 prostate cancer cases and 1,190 controls (for a total of 1,320 prostate cancer cases and 1,255 controls). Cases and controls were selected from the on-going Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial and were frequency matched on age, ethnicity, time-period since initial screening, and date of blood draw. Single-locus analyses were conducted using conditional logistic regression. In addition, we did a haplotype analysis for the three IL-10 SNPs tested. Overall, no associations were detected between the seven polymorphisms in the four cytokine genes examined in this study and prostate cancer risk. Further stratifying by use of nonsteroidal anti-inflammatory drugs did not modify the associations. Findings were similar for early or advanced prostate cancers. Similarly, we observed no association between the major IL-10 haplotypes and the risk of prostate cancer. At least seven common polymorphisms in genes of inflammatory cytokines IL-1B, IL-6, IL-8, and IL-10 do not seem to play a role in the risk of prostate cancer. (Cancer Res 2006; 66(8): 4525-30)
Misclassification of Bronchioloalveolar Carcinoma with Cytologic Diagnosis of Lung Cancer
Authors: Dan J. Raz, Jason A. Zell, Anthony N. Karnezis, Anobel Odisho, S.H. Ignatius Ou, Hoda Anton-Culver, David M. Jablons
Journal: Journal of Thoracic Oncology (2006)
Increased Survival, Proliferation, and Migration in Metastatic Human Pancreatic Tumor Cells Expressing Functional CXCR4
Authors: Federica Marchesi, Paolo Monti, Biagio Eugenio Leone, Alessandro Zerbi, Annunciata Vecchi, Lorenzo Piemonti, Alberto Mantovani, Paola Allavena
Journal: Cancer Research (2004)

Abstract In this study, we have evaluated 11 pancreatic tumor cell lines and tumor cells from surgical samples of patients with pancreatic adenocarcinoma for expression of the chemokine receptor CXCR4. Six of 11 cell lines expressed detectable mRNA of CXCR4, with three cell lines (AsPC1, Capan1, and Hs766T) having substantial amounts of transcripts. Expression was higher in lines derived from metastatic lesions compared with those derived from primary tumors. Different inflammatory cytokines did not modify expression, whereas IFN-γ down-regulated and hypoxia up-regulated CXCR4 transcripts. Transcript expression was associated with surface expression in pancreatic carcinoma cell lines. All surgical carcinoma samples tested expressed higher levels of CXCR4 than normal pancreatic ducts, which were used as reference tissue. The chemokine CXCL12 induced chemotaxis in CXCR4-positive pancreatic carcinoma cell lines, which was inhibited by anti-CXCR4 monoclonal antibody and by the antagonist AMD3100. Transendothelial migration, Matrigel invasion, and activation of matrix metalloproteases were also enhanced by CXCL12. In CXCR4-positive cell lines, CXCL12 stimulated cell proliferation. The cell line Hs766T produces high levels of CXCL12, and addition of the CXCR4 antagonist AMD3100 partially inhibited proliferation, indicating an autocrine loop. Moreover, the addition of exogenous CXCL12 inhibited apoptosis induced by serum starvation. These results indicate that the CXCR4 receptor is frequently expressed in metastatic pancreatic tumor cells. CXCR4 not only stimulates cell motility and invasion but also promotes survival and proliferation. Strategies to target CXCR4 expressed on tumor cells may be of benefit in patients with pancreatic cancer.
Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
Authors: Arun J. Sanyal, Colin Banas, Carol Sargeant, Velimir A. Luketic, Richard K. Sterling, Richard T. Stravitz, Mitchell L. Shiffman, Douglas Heuman, Adrian Coterrell, Robert A. Fisher, Melissa J. Contos, Alan S. Mills
Journal: Hepatology (2006)

The objective of this study was to prospectively define outcomes of cirrhosis due to nonalcoholic steatohepatitis (NASH) and compare them with those associated with hepatitis C virus (HCV) infection. We compared 152 patients with cirrhosis due to NASH with 150 matched patients with cirrhosis due to HCV. Over 10 years, 29/152 patients with cirrhosis due to NASH died compared with 44/150 patients with HCV (P < .04). This was mainly due to the lower mortality rate in patients with Child class A cirrhosis due to NASH versus HCV (3/74 vs. 15/75; P < .004). There were no significant across-group differences in mortality in patients with Child class B or C cirrhosis. Sepsis was the most common cause of death in both groups; patients with NASH had a higher cardiac mortality (8/152 vs. 1/150; P < .03). Patients with Child class A cirrhosis due to NASH also had a significantly lower risk of decompensation, defined by a 2-point increase in Child-Turcotte-Pugh score (P < .007). Cirrhosis due to NASH was associated with a lower rate of development of ascites (14/101 vs. 40/97 patients at risk; P < .006). NASH also had a significantly lower risk of development of hepatocellular carcinoma (10/149 vs. 25/147 patients at risk; P < .01). In conclusion, compensated cirrhosis due to NASH is associated with a lower mortality rate compared with that due to HCV. It is also associated with a lower rate of development of ascites, hyperbilirubinemia, and hepatocellular carcinoma. However, cardiovascular mortality is greater in patients with NASH. (HEPATOLOGY 2006.)
Coronary angioplasty versus repeat coronary artery bypass grafting for patients with previous bypass surgery
Authors: William J. Stephan, James H. O'Keefe, Jeffrey M. Piehler, Ben D. McCallister, Rajiv S. Dahiya, Thomas M. Shimshak, Robert W. Ligon, Geoffrey O. Hartzler
Journal: Journal of the American College of Cardiology (1996)
NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines
Authors: Serges P Tsofack, Chantal Garand, Chris Sereduk, Donald Chow, Meraj Aziz, David Guay, Hongwei H Yin, Michel Lebel
Journal: Molecular Cancer (2011)

Abstract Background YB-1 is a multifunctional protein that affects transcription, splicing, and translation. Overexpression of YB-1 in breast cancers causes cisplatin resistance. Recent data have shown that YB-1 is also overexpress in colorectal cancer. In this study, we tested the hypothesis that YB-1 also confers oxaliplatin resistance in colorectal adenocarcinomas. Results We show for the first time that transfection of YB-1 cDNA confers oxaliplatin resistance in two colorectal cancer cell lines (SW480 and HT29 cell lines). Furthermore, we identified by mass spectrometry analyses important YB-1 interactors required for such oxaliplatin resistance in these colorectal cancer cell lines. A tagged YB-1 construct was used to identify proteins interacting directly to YB-1 in such cells. We then focused on proteins that are potentially involved in colorectal cancer progression based on the Oncomine microarray database. Genes encoding for these YB-1 interactors were also examined in the public NCBI comparative genomic hybridization database to determine whether these genes are localized to regions of chromosomes rearranged in colorectal cancer tissues. From these analyses, we obtained a list of proteins interacting with YB-1 and potentially involved in oxaliplatin resistance. Oxaliplatin dose response curves of SW480 and HT29 colorectal cancer cell lines transfected with several siRNAs corresponding to each of these YB-1 interactors were obtained to identify proteins significantly affecting oxaliplatin sensitivity upon gene silencing. Only the depletion of either NONO or RALY sensitized both colorectal cancer cell lines to oxaliplatin. Furthermore, depletion of NONO or RALY sensitized otherwise oxaliplatin resistant overexpressing YB-1 SW480 or HT29 cells. Conclusion These results suggest knocking down NONO or RALY significant counteracts oxaliplatin resistance in colorectal cancers overexpressing the YB-1 protein.
Liver Transplantation in Man--IV, Haemorrhage and Thrombosis
Authors: P. T. Flute, M. O. Rake, R. Williams, M. J. Seaman, R. Y. Calne
Journal: BMJ (1969)

Blood coagulation and fibrinolytic factors have been measured in 13 patients treated by liver transplantation. During operation intravascular coagulation and fibrinolysis were increased, but seldom to a degree which would cause abnormal bleeding. Measurement of the catabolism of radioactive fibrinogen showed that increased intravascular coagulation continued for long periods after the operation. Despite secondarily increased fibrinolysis, there was a high incidence of thrombosis. Treatment with anticoagulants or with fibrinolysis inhibitors may be valuable in these patients.
The Natural History of Electrocardiographic Preexcitation in Men
Authors: Andrew D. Krahn, Jure Manfreda, Robert B. Tate, Francis A. L. Mathewson, T. Edward Cuddy
Journal: Annals of Internal Medicine (1992)

▪Objective: To examine the natural history of preexcitation occurring on the routine electrocardiogram (ECG). ▪Design: A longitudinal cohort study of 3983 originally healthy men followed prospectively for 40 years. ▪Setting: Free-living (community-dwelling) study members residing predominantly in Canada. ▪Participants: Nineteen male study members with preexcitation occurring during routine examination in the 40-year follow-up of the Manitoba Follow-up Study. ▪Measurements: Routinely requested clinical examinations and ECGs, supplemented by information supplied by the study member or his physician. ▪Main Results: Ten study members were found to have preexcitation at enrollment, for a prevalence of 2.5 per 1000 (95% Cl, 1.2 to 4.6). A delta wave was first detected during follow-up in an additional nine study members. Seventeen of 19 study members did not have the delta wave at some later time, and preexcitation was intermittently present in most of these members. Over time there was a loss of preexcitation, with 15 of 19 study members no longer exhibiting a delta wave by the end of follow-up. Five of 11 study members with symptoms had physician confirmation of an arrhythmia. Fourteen study members remain alive, and none of the five deaths was attributed to preexcitation. ▪Conclusions: Preexcitation found on routine ECG in our originally healthy male study group did not confer excess morbidity or mortality, even in those study members who developed symptomatic arrhythmias. Most preexcitation was intermittent and disappeared over time.
Acquired immunodeficiency syndrome in Romania
Authors: F. Popovici, R.C. Apetrei, L. Zolotusca, N. Beldescu, A. Calomfirescu, Z. Jezek, D.L. Heymann, A. Gromyko, B.S. Hersh, M.J. Oxtoby
Journal: The Lancet (1991)
Dilantin®-Induced Disseminated Intravascular Coagulation with Purpura Fulminans
Authors: STEPHAN R. TARGAN
Journal: Annals of Internal Medicine (1975)

A patient developed disseminated intravascular coagulation with purpura fulminans 1 month after starting Dilantin® therapy for a seizure disorder. In addition, the patient developed exfoliative dermatitis, hepatitis, cutaneous vasculitis, and microangiopathic hemolytic anemia. She was successfully treated with adrenal steroids and heparin for her purpura fulminans. The hepatitic dermatologic, along with hemorrhagic, complications of Dilantin® are reviewed, and the possible origin of the vasculitis and disseminated intravascular coagulation is discussed.
Von Willebrand factor and soluble E-selectin in hyperlipidaemia: Relationship to lipids and vascular disease
Authors: Andrew D. Blann, Alison Davis, J. Paul Miller, Charles N. McCollum
Journal: American Journal of Hematology (1997)

Our objective was to determine whether endothelial cell products von Willebrand factor and soluble E-selectin are related to serum lipids, lipoprotein (a), and vascular disease in patients with hyperlipidaemia. In order to achieve our aim, blood samples were obtained for four experiments from 1) 160 patients (49 with symptomatic vascular disease) with hypercholesterolaemia and an equal number of age and sex matched controls; 2) 31 patients who were studied serially before and after successful resolution of their hypercholesterolaemia; 3) 15 patients with hypertriglyceridaemia; and 4) 20 controls, half of whom consumed a lipid-rich breakfast. von Willebrand factor and soluble E-selectin were measured by enzyme linked immunosorbent assay (ELISA) using commercial reagents. In experiment (1) von Willebrand factor was increased in the patients with hypercholesterolaemia (P=0.0077) and was higher still in patients with vascular disease (P<0.0001). Soluble E-selectin was not influenced by hypercholesterolaemia or vascular disease. The correlation of von Willebrand factor with total and LDL cholesterol (both P<0.001) remained after both age and blood pressure were controlled. Experiment (2) showed that serial studies in patients over an average of 7 months a reduction in total cholesterol was associated with a reduction in von Willebrand factor (r=0.51, P=0.002). Experiment (3) demonstrated that von Willebrand factor was not increased in patients with hypertriglyceridaemia (median 8.9 mmol/L), and in experiment (4) a lipid-rich breakfast taken by fasted, healthy controls produced an increase in serum triglycerides (P<0.01) but did not influence von Willebrand factor over an 8 hour period. We conclude that von Willebrand factor, but not soluble E-selectin, is raised in hypercholesterolaemia and therefore may be a potential indicator of endothelial cell physiology in subjects with, or at risk of, atherosclerotic vascular disease. Am. J. Hematol. 55:15-23, 1997. © 1997 Wiley-Liss, Inc.