tbuckley/cabot-search huggingface dataset:
The Changing Face of Asthma-Reply
Authors: Diane K. Wagener
Journal: JAMA (1991)

<h3>In Reply.—</h3> In our articles, the intent was to demonstrate that recent trends are not an artifact resulting from diagnostic changes. The records systems used for our analyses were not designed to collect information on the many risk factors for asthma. The National Hospital Discharge Survey is based on a sample of hospitals and does not have data appropriate for small, local-area analysis of exposures to factors such as air quality or person-specific information. The US vital record system can be used to study small, local areas. However, death from asthma is a relatively infrequent event; hence, reliable statistics cannot be calculated for small populations, or even large populations over a small period of time. Dr Christian reasonably suggests that air pollutants may be influencing these recent trends. A number of experimental studies and analyses of health event clusters implicate various air pollutants as bronchial irritants. Questions related to asthma
Familial Hodgkin Disease
Authors: Emeka G. Olisa
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Approximately 100 cases of familial Hodgkin disease are recorded in the literature. None showed any distinctive clinical or pathological features.<sup>1</sup>No multiplecase family with Hodgkin disease has been described in blacks, as far as it can be ascertained. This report describes the almost simultaneous occurrence of Hodgkin disease in two black brothers. Both developed nodular sclerosing Hodgkin disease of the right inguinal lymph nodes. <h3>Report of Cases.—Case 1.—</h3> This 24-year-old black man was first seen in 1971 because of inguinal lymph node enlargement on the right side. Biopsy yielded a diagnosis of reactive hyperplasia. Three years later, in May 1974, an enlarged 7×4-cm mass, occurring at the same site, was diagnosed as nodular sclerosing Hodgkin disease, from a biopsy specimen. The patient is employed by a construction firm as a journeyman. Both parents are alive; his mother has hypertension. Physical examination, apart from the
Medication Reconciliation Practices and Potential Clinical Impact of Unintentional Discrepancies
Authors: Bruno Michel, Bapiste Quelennec, Emmanuel Andres
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
901. Targeting of Viral Vectors to Motor Neurons by Botulinum Toxin Binding Domain To Treat ALS
Authors: Yang Lu, Robert Adams, Wenji Sun, Iris Lee, Irina Debromilskaya, Daniel B. Drachman
Journal: Molecular Therapy (2006)

Amyotrophic lateral sclerosis (ALS) is a progressive disorder of motor neurons, leading inevitably to paralysis and death. Recent advances in knowledge of the pathogenesis of ALS have suggested several attractive candidate treatment strategies. However, a key problem in ALS therapy in human patients is the enormous difficulty in delivering agents to the motor neurons. Attempts to deliver agents orally, by injections, or even by infusions into the subarachnoid space have generally not been successful, possibly because of limited access to motor neurons. Recently, viral vectors injected intramuscularly in mice have been used with some success to deliver potentially therapeutic genes to motor neurons, via retrograde transport. However, the efficiency of this method is limited, and the prospect of extensive intramuscular injections is daunting.
Localization of the gene for coagulation factor XIII a-chain to chromosome 6 and identification of sites of synthesis.
Authors: L J Weisberg, D T Shiu, C S Greenberg, Y W Kan, M A Shuman
Journal: Journal of Clinical Investigation (1987)

Factor XIII, the clotting factor essential for covalent stabilization of the fibrin clot, is a heterodimer consisting of a2 and b2 subunits, with catalytic function residing in the a-chain. In order to address questions regarding sites of synthesis and chromosomal localization of the Factor XIII a-chain, cDNA was cloned from a lambda gt11 human placental cDNA library. Nucleotide and amino acid sequences were determined from the cDNA. Amino acid sequencing of purified platelet Factor XIII a-chains confirmed the authenticity of the lambda gt11 clone. The gene for Factor XIII a-chain was mapped uniquely to chromosome 6. Northern blot analysis of human placental and U937 (monocytelike) cell poly (A)+ mRNA showed a single approximately 4.0-kb message for the Factor XIII a-chain. These results provide conclusive evidence that the a-chain is synthesized by placenta and monocyte cell lines.
Achieving guideline-based asthma control: does the patient benefit?
Authors: E.D. Bateman, L.F. Frith, G.L. Braunstein
Journal: European Respiratory Journal (2002)

Asthma management guidelines define asthma control, but the outcome criteria used do not include the patient's own assessment of their health. The objective of the present study was to determine the association between the achievement of asthma control, as defined by the Global Initiative for Asthma (GINA) guidelines, and patient-assessed asthma-related quality of life (QOL), particularly whether maximal or near-maximal QOL scores were attainable. Clinical data from three studies that compared salmeterol/fluticasone propionate combination therapy (SFC) with other treatments in patients with persistent asthma were retrospectively analysed. Achievement of asthma control was determined over an 8-week period in each study according to six parameters derived from the GINA guideline treatment goals. Asthma Quality of Life Questionnaire (AQLQ) scores (a 7-point scale, where 1=severe impairment and 7=no impairment) were analysed by treatment group for well-controlled and not well-controlled patients. The analysis showed that, across a range of severities, well-controlled asthma patients had consistently higher AQLQ scores at endpoint and larger AQLQ improvements from baseline, than patients who were not well controlled. For many well-controlled patients, endpoint scores approached 7, indicating little or no impact of asthma on their QOL. However, AQLQ scores of not well-controlled patients also improved substantially in some treatment groups, particularly the SFC group. These results suggest a relationship between the achievement of guideline-based asthma control and improvements in quality of life to levels where there is little or no impact of asthma on quality of life. Guideline-based asthma control is therefore beneficial to the patient and should be tested in prospective studies.
Host immunity affects survival in myelodysplastic syndromes: Independent prognostic value of the absolute lymphocyte count
Authors: Nisha L. Jacobs, Shernan G. Holtan, Luis F. Porrata, Svetomir N. Markovic, Ayalew Tefferi, David P. Steensma
Journal: American Journal of Hematology (2009)

Abstract The prognostic significance of the peripheral blood absolute lymphocyte count (ALC) has been carefully examined in lymphoid malignancies, but the importance of the baseline ALC in chronic myeloid neoplasms is less clear. In a recent analysis of myelodysplastic syndromes (MDS) associated with deletion of chromosome 5q, we observed that an ALC &lt; 1.2× 10 9 cells/L at diagnosis is independently associated with poorer survival. Clinicopathological data from 503 patients with non‐del(5q) MDS evaluated at Mayo Clinic between 1996 and 2007 were reviewed to determine the prognostic impact of ALC at diagnosis in non‐del(5q) MDS. Patients with MDS and an ALC at diagnosis ≥1.2× 10 9 ( N = 248) experienced a superior overall survival (OS) compared with patients with an ALC &lt; 1.2× 10 9 /L ( N = 255, median OS of 26.6 months versus 18.5 months, P &lt; 0.001, respectively). ALC at diagnosis was an independent predictor for OS when compared with the International Prognostic Scoring System and the WHO‐based Prognostic Scoring System. This study suggests that ALC at diagnosis is a prognostic factor for OS in MDS, and argues in favor of further studies to assess the role of host immunity in MDS clinical outcomes. Am. J. Hematol. 2010. © 2009 Wiley‐Liss, Inc.
Bilateral central retinal artery occlusion secondary to sickle cell disease
Authors: Ishak A.E. Mansi, Ahmed M. Alkhunaizi, Adil A. Al-Khatti
Journal: American Journal of Hematology (2000)

To the Editor: Painful crisis is the most common complication in patients with sickle cell disease (SCD), while central retinal artery occlusion (RAO)
The Present Status of Surgery for Rheumatic Heart Disease.
Authors: Dwight C. McGoon
Journal: Annals of Internal Medicine (1965)

s1 May 1965The Present Status of Surgery for Rheumatic Heart Disease.Dwight C. McGoon, M.D.Dwight C. McGoon, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1073_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSurgery for valvular rheumatic heart disease can now be accomplished with a startling degree of safety and success. It is within the surgeon's capability to replace the aortic valve at a hospital mortality rate of less than 2%, the mitral valve at 14%, and both of these valves or all three valves (including the tricuspid) at a risk of 14%. The safety of the procedure itself, however, does not yet allow recommendation for early surgery in the asymptomatic patient, since certain complications relating to prosthetic valves may appear even after an apparently normal convalescence. The selection of patients for operation... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1073-1073KeywordsAortic valveCardiac surgeryCardiovascular therapyConvalescenceDeath ratesSafetySurgery Issue Published: 1 May 1965 PDF DownloadLoading ...
THE VAGINAL ROUTE IN OPERATION FOR RUPTURED TUBAL PREGNANCY.
Authors: J. WESLEY BOVÉE
Journal: JAMA (1897)

Ruptured tubal pregnancy has been so forciby kept to the front during the past fifteen years, that many of the profession have been led to think it is a condition in which, without exception, the life of the individual suffering from it is in great danger. We are obliged to believe it is not so dangerous in many cases, and that quite often it escapes attention either from the little discomfort caused by it, or from the physician failing to realize the condition and procrastination allowing the absorption of the escaped blood. This latter variety can not include a very large percentage of cases however, or it would more often be found as a complication of other forms of pelvic disease. We have reason to think also, that occasionally Fallopian tubes are ruptured by over-distension from blood, not due to pregnancy, but mistaken for that condition. We have recently had
Impasse over patient consent may delay NHS computerisation
Authors: Michael Cross
Journal: BMJ (2006)

A continuing impasse over patient consent threatens to delay the most critical phase of the £12.4bn (€18.3bn; $24.1bn) programme to computerise the NHS in England. 

From March next year, early adopter NHS organisations are expected to begin loading summaries of clinical information onto a central electronic “spine,” from which they will be available to any authorised user. 

However, the BMA and the central agency Connecting for Health remain at odds over whether patients should give explicit consent before records go on the system. According to the latest survey by the medical polling company Medix, 51% of GPs said they would not upload records without explicit consent. 

Figures published …
Theory and Practice of Histological Techniques
Authors: Robin T. Vollmer
Journal: JAMA (1983)

The second edition of this book is a complete and well-written work on histological techniques, and I recommend it highly. Its 31 chapters and 22 authors leave very little subject matter untreated. In addition to chapters on routine and special stains, there are chapters on electron microscopy, including the techniques of scanning electron microscopy, electron probe, freeze fracture, and electron immunohistochemistry; on immunohistochemistry, including the newer<i>p</i>-aminophenazone (PAP) immunoperoxidase method; on histomorphometry, including stereology; on plastic-embedding techniques; on autoradiography; and on bone evaluation, including quantitation of osteoid in undecalcified specimens. These appear with excellent discussions of fixation, laboratory safety, staining theory, frozensection techniques, and amyloid. Potentially important omissions were few but included Bank's method for secondary fixation with zinc sulfate,<sup>1</sup>Michel's transport-fixative solution for preservation of immunoglobulins,<sup>2</sup>Wright's potassium permanganate technique for differentiating AA amyloid from other amyloids,<sup>3</sup>Warkel's modified Warthin-Starry stain for melanin,<sup>4</sup>use
USEFULNESS OF RIGHT VENTRICULAR VOLUME ANALYSIS WITH FOUR DIMENSIONAL ECHOCARDIOGRAPHY TO MEASURE RIGHT VENTRICULAR VOLUME AND FUNCTION : VALIDATION WITH CARDIAC MRI
Authors: Masaomi Gohbara, Noriaki Iwahashi, Nobuhiko Maejima, Mitsuaki Endo, Kengo Tsukahara, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2012)
Aneurysm of Common-Iliac Arteries With Coarctation of the Aorta
Authors: Bernard L. Segal
Journal: JAMA (1966)

AORTIC ANEURYSM is a complication of coarctation of the aorta. Abbott's classic autopsy studies revealed that 39 of 200 cases with coarctation of the aorta had an associated aortic aneurysm.<sup>1</sup>Reifenstein and his associates reviewed 104 additional autopsies on patients who had died with this defect; an associated aneurysm was present in 24.<sup>2</sup>In other studies, aneurysms were found to occur in conjunction with coarctation in approximately 7% to 23% of cases reported.<sup>3,4</sup>In addition to the usual thoracic aortic aneurysm, Skandalakis and his associates found, in a total of 106 patients with coarctation of the aorta, 9 cases of aneurysms of the sinus of Valsalva, 12 aneurysms of the intercostal arteries, and 6 of extra-thoracic arteries.<sup>5</sup>These extra-thoracic aneurysms involve the bronchial artery, superior mesenteric artery, innominate artery, vertebral and rarely the common-iliac artery. This review also reports that 14 patients had multiple aneurysms.<sup>5</sup>
The Economic Laws of Scientific Research
Authors: T. Wilkie
Journal: BMJ (1996)

Terence Kealey Macmillan, £15.99, pp 382 ISBN 0 333 65755 1

Kealey believes that Britain has too many scientists; that the state should not finance scientific research (other than for military purposes); and that if the state withdraws then this will release money in the form of tax cuts, allowing private industry or charities to step into the gap. Because many individuals would take the decisions to fund science if it were left to the private and charitable sectors, this would lead to a more rational outcome than the state would produce.

The problem with this ideology is that the experiment has already been tried. Until the first world war, successive British governments took little interest in science other …
FURTHER OBSERVATIONS ON THE BLOOD CHOLESTEROL OF RABBITS IN RELATION TO ATHEROSCLEROSIS
Authors: Kenneth B. Turner, Emily H. Bidwell
Journal: The Journal of Experimental Medicine (1935)

1. The action of potassium iodide in preventing a significant rise in the blood cholesterol of rabbits fed cholesterol was temporary. After about 4 months it lost its effectiveness and the blood cholesterol rose. 2. In rabbits with hypercholesterolemia resulting from long continued cholesterol feeding, the administration of potassium iodide caused a marked rise in the blood cholesterol. 3. On the other hand, dried whole thyroid given to such animals produced a sharp fall in the blood cholesterol. This fall was temporary and was followed by a rise to new high levels. 4. In thyroidectomized rabbits fed cholesterol and potassium iodide, both thyroid and thyroxin delayed but did not prevent a rise in blood cholesterol. Even with the hypercholesterolemia in these animals, however, the incidence of atherosclerosis was low. 5. Age apparently played a part in determining the response of the blood cholesterol to cholesterol feeding. In a group of old rabbits when compared with a younger group the rise in the cholesterol of the blood was greater and the subsequent return toward normal was slower when the feeding was stopped.
Effect of Low Molecular Weight Dextran on Red Blood Cell Charge During Clinical Extracorporeal Circulation
Authors: EUGENE F. BERNSTEIN, FRED G. EMMINGS, ROBERT L. EVANS, ALDO CASTANEDA, RICHARD L. VARCO
Journal: Circulation (1963)

Low molecular weight dextran, when included in the priming mixture of a pump oxygenator for clinical extracorporeal circulation, almost uniformly increased the electric charge of red blood cells. In perfusions in which 5 per cent dextrose and water were used as the priming vehicle, there appeared to be no change in red blood cell charge. The increase in red blood cell electronegativity, associated with the presence of low molecular weight dextran, appeared to decrease red blood cell aggregation and permit improved tissue perfusion.
Gallbladder Adenocarcinoma with Florid Neuroendocrine Cell Nests and Extensive Paneth Cell Metaplasia
Authors: Mika Sakaki, Mitsuyoshi Hirokawa, Toshiaki Sano, Hidehisa Horiguchi, Shingo Wakatsuki, Shinya Ogata
Journal: Endocrine Pathology (2000)
The Necessity for Better Provision for Legal Medicine in This Country.
Authors: Walter T. Dannreuther
Journal: JAMA (1906)

Jersey City, N. J., Oct. 6, 1906. <h3>To the Editor:</h3> —In a letter inThe Journal, September 8, I took exception to a statement you had made in a previous editorial (August 25) that certain New York medical schools make no mention of the subject of medical jurisprudence. In informing you that a course in medical jurisprudence is given each year at the Long Island College Hospital, Brooklyn, my letter was written only to correct your error. InThe Journal, October 6, p. 1116, Dr. Leffmann refers rather sarcastically to my letter of September 8. I had no intention of discussing the value of instruction in medical jurisprudence as it is taught or the merits of any one particular course. The course I referred to, however, does consist of exactly what Dr. Leffmann mentions: "Questions of ethics, general and legal, limitations of professional duties and rights, and cognate questions." And
Studies on the Activity of Pyruvate Kinase in Hemolysates of Normal and Glucose-6-Phosphate Dehydrogenase-deficient Erythrocytes.
Authors: Robin D. Powell
Journal: Annals of Internal Medicine (1965)

s1 May 1965Studies on the Activity of Pyruvate Kinase in Hemolysates of Normal and Glucose-6-Phosphate Dehydrogenase-deficient Erythrocytes.Robin D. Powell, M.D., Richard L. DeGowin, M.D.Robin D. Powell, M.D.Search for more papers by this author, Richard L. DeGowin, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1086_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPyruvate kinase catalyzes a key, adenosine triphosphate-generating step of anaerobic glycolysis. This pathway constitutes the main source of energy in mature erythrocytes of human beings. We have studied the activity of pyruvate kinase in hemolysates of erythrocytes from normal and from glucose-6-phosphate dehydrogenase (G6PD)-deficient American Negro men. G6PD-deficient erythrocytes are susceptible to drug-induced hemolysis. The life span of G6PD-deficient erythrocytes in vivo is shorter than normal, even in the absence of hemolytic drugs, and older G6PD-deficient erythrocytes are more susceptible to hemolysis than are younger cells.The mean activity of pyruvate kinase in hemolysates of erythrocytes from 12 G6PD-deficient men... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHEMOLYSIS DUE TO INHERITED ERYTHROCYTE ENZYME DEFICIENCIESHEMOLYSIS DUE TO INHERITED ERYTHROCYTE ENZYME DEFICIENCIES 1 May 1965Volume 62, Issue 5Page: 1086-1086KeywordsAdenosineCellsDehydrogenasesDrugsPyruvate Issue Published: 1 May 1965 PDF DownloadLoading ...
Clinical crossroads: an 88-year-old woman facing the end of life
Authors: G. L. Solomon
Journal: JAMA (1997)

To the Editor.  —While I am reluctant to find fault with Dr Lynn's article 1 elucidating the issues involved with dying patients and offering concrete suggestions for managing them, I am disturbed by the implication that achieving excellence in the care of the dying patient will have an adverse financial effect under capitation. While this is a possibility, there are no data offered to support this statement.  The patients in health maintenance organizations who switch medical groups will probably need to leave their specialists along with their primary care physician. I believe that ill patients would want to stay with physicians who know them rather than move to a new group (even if it does have a reputation for excellence). Also, there is no reason to assume that awareness of an organization's exceptional reputation would not attract a higher proportion of healthy patients than ill patients. I believe sicker patients