tbuckley/cabot-search huggingface dataset:
Association of Hexachlorobenzene (HCB), Dichlorodiphenyltrichloroethane (DDT), and Dichlorodiphenyldichloroethylene (DDE) with <i>in Vitro</i> Fertilization (IVF) Outcomes
Authors: Shruthi Mahalingaiah, Stacey A. Missmer, Arnab Maity, Paige L. Williams, John D. Meeker, Katharine Berry, Shelley Ehrlich, Melissa J. Perry, Daniel W. Cramer, Russ Hauser
Journal: Environmental Health Perspectives (2011)

Hexachlorobenzene (HCB), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE) are persistent chlorinated pesticides with endocrine activity that may adversely affect the early stages of human reproduction.Our goal was to determine the association of serum levels of HCB, DDT, and DDE with implantation failure, chemical pregnancy, and spontaneous abortion in women undergoing in vitro fertilization (IVF) from 1994 to 2003.Levels of HCB and congeners of DDT and DDE were measured in serum collected during the follicular phase. Multivariable-adjusted statistical models accommodating multiple outcomes and multiple cycles per woman were used to estimate the relation between serum pesticide levels and IVF outcomes.A total of 720 women with a mean ± SD age 35.4 ± 4.2 years at enrollment contributed 774 IVF cycles. All samples had detectable levels of HCB, DDT, and DDE, with median levels of 0.087 ng/g serum for HCB, 1.12 ng/g serum for total DDT, and 1.04 ng/g serum for p,p´-DDE. Compared with the lowest quartile (Q1) of HCB, the lipid- and multivariable-adjusted odds ratio (OR) for failed implantation was significantly elevated for those with higher HCB quartiles [Q2-Q4; adjusted ORs: for Q2, 1.71; 95% confidence interval (CI): 1.03, 2.82; for Q3, 2.30; 95% CI: 1.39, 3.81; for Q4, 2.32; 95% CI: 1.38, 3.90] and showed a significantly increasing trend (p = 0.001). No statistically significant associations were observed between DDT/DDE and IVF outcomes or between HCB and chemical pregnancy or spontaneous abortion.Serum HCB concentrations were on average lower than that of the general U.S. population and associated with failed implantation among women undergoing IVF.
THE RECONSTRUCTION OF THE PELVIC STRUCTURES INCIDENT TO LESIONS OF PERINEUM.
Authors: HENRY O. MARCY
Journal: JAMA (1899)

When in London some time ago, the plastic repair of the pelvic structures was under discussion. One of the most distinguished surgeons said to me: "You will at least grant that we have settled upon the better methods for the restoration of the perineum," and yet, on further inquiry, I found that he advocated his own peculiar operation as the best, and disagreed with every other writer on the subject. I am quite sure that the methods in practice by distinguished operators differ essentially, both in principle and technic, and that which is of the most importance, the resultant, is often defective and unsatisfactory. I can not help thinking that this is due primarily to an imperfect knowledge of the structures and functions of the parts involved. Of the structures, the anatomy of the pelvic floor in woman has very generally been imperfectly described and studied. I review my own
Effect of acidosis on chloride transport in the cortical thick ascending limb of Henle perfused in vitro.
Authors: C S Wingo
Journal: Journal of Clinical Investigation (1986)

The present studies examined the effect of acute in vitro acidosis on chloride reabsorption in the rabbit cortical thick ascending limb of Henle (cTALH). Four protocols were used: hypercapnic acidosis; "isocapnic" peritubular acidosis (bath bicarbonate reduction to 10 mM); isocapnic luminal acidosis (luminal bicarbonate reduction to 10 mM); isocapnic peritubular acidosis in the absence of luminal potassium. Transepithelial voltage (VT) decreased during hypercapnic acidosis and increased with recovery. Chloride reabsorption (pmol X mm-1 X min-1) decreased from 50.3 +/- 8.4 to 15.7 +/- 5.6, then increased to 45.6 +/- 11.1 with recovery. Likewise, VT was decreased reversibly during isocapnic peritubular acidosis, and chloride reabsorption decreased by 60%. Chloride reabsorption was greater (28.3 +/- 3.6) when tubules were perfused at normal luminal pH than at an acidotic luminal pH (11.4 +/- 4.5; P less than 0.05). Luminal potassium removal reduced chloride transport, and acidosis had no significant additional effect. Decreased chloride reabsorption in the cTALH during acidosis could contribute to the chloruresis associated with systemic acidosis. The symmetrical nature of this effect suggests that acidosis inhibits chloride reabsorption through an effect on cytosolic pH.
Graphical method for depicting randomised trials of complex interventions
Authors: Rafael Perera, Carl Heneghan, Patricia Yudkin
Journal: BMJ (2007)

Making the what, when, and who of non-drug treatments easier to understand would benefit researchers and readers, say Rafael Perera and colleagues A graphical method for depicting randomised trials of complex interventionsComplex interventions consist of several separate components combined to produce a desired outcome. 1 Evaluation of such interventions in randomised trials will generally lead to complex comparisons between trial groups. 2 Moreover, text descriptions in journal articles may obscure aspects of the interventions in the trial and hinder comparison between them.To counter these problems we have produced a single image that presents the components of all interventions in the trial and compares different treatment arms.The aim is to clarify the structure of the contrasted interventions and thus aid interpretation of the trial results. The need for clear comparisonsWe studied 169 randomised trials of non-drug interventions in primary care published between 1999 and 2003.We searched Medline, PSIQInfo, Bioabstracts, and Embase using the free text search terms "randomised controlled trials" and "primary care" and their synonyms, and excluding the term "placebo" appearing in the title or abstract; we also hand searched reference lists of retrieved papers.In many of these papers the interventions were incompletely described.We identified three principal problems: identifying the different components of the intervention, establishing the time at which components were delivered, and defining the differences between intervention arms.To clarify these aspects we suggest that it would be helpful to depict the experimental and control interventions graphically.The proposed graph is similar to a flowchart, with each treatment arm represented in a specific column, and with all the intervention components presented within that column.The time scale of the trial runs from top to bottom on the left hand side, with the times of randomisation and outcome measurement (or measurements) clearly marked.Each component of an intervention is depicted separately.Components delivered concurrently are displayed side by side, while those delivered consecutively are shown one beneath the other.We regard components either as objects or activities.Objects are represented by squares (to reflect their fixed nature) and activities by circles (to reflect their flexibility).Different components are labelled with different letters.Below the diagram, a legend gives a brief description of each component, including its form, content, functions, and details of who delivers it.If necessary, additional material can be given in the text.This approach will convey as much information as a written description, will clarify the basic structure of the experimental intervention, and elucidate the differences between treatment arms, as the examples below show.
1099-86 The medicine, angioplasty, or surgery study (MASS II): Analyses in male and female populations of medical therapy, coronary angioplasty, and bypass surgery study during the first year of follow-up
Authors: Paulo R Soares, Whady A Hueb, Bernard J Gersh, Desiderio Favarato, Neusa H Lopes, Luiz A.M Cesar, Sergio A Oliveira, Jose A.F Ramires
Journal: Journal of the American College of Cardiology (2004)
Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells
Authors: Christine Karlsson, Aurélie Baudet, Natsumi Miharada, Shamit Soneji, Rajeev Gupta, Mattias Magnusson, Tariq Enver, Göran Karlsson, Jonas Larsson
Journal: Blood (2013)
Significance of Antibody to DNA in Systemic Lupus Erythematosus.
Authors: George J. Friou
Journal: Annals of Internal Medicine (1964)

s1 April 1964Significance of Antibody to DNA in Systemic Lupus Erythematosus.George J. Friou, M.D., F.A.C.P., Salvador P. Casals, M.D., Lynn Myers, M.D., Perry O. Teague, M.D.George J. Friou, M.D., F.A.C.P.Search for more papers by this author, Salvador P. Casals, M.D.Search for more papers by this author, Lynn Myers, M.D.Search for more papers by this author, Perry O. Teague, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-741 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudy of antinuclear and other antitissue antibodies has contributed to the increasing interest in concepts of immunologic mechanisms of pathogenesis of mesenchymal diseases, especially systemic lupus erythematosus. In spite of this, there has been no clinical or direct experimental evidence relating any of the antinuclear antibodies to specific disease manifestations.It has been our contention that the significance of antinuclear antibodies can only be properly elucidated by studies which distinguish between individual factors. To facilitate distinction of antibodies with different specificities we have previously described a spot test for detection of antibody to nucleoprotein, and a characteristic nuclear reaction pattern... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: George J. Friou, M.D., F.A.C.P.; Salvador P. Casals, M.D.; Lynn Myers, M.D.; Perry O. Teague, M.D.Affiliations: Oklahoma City, Oklahoma PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 741-741KeywordsAntinuclear antibodiesDNALupus erythematosusPathogenesisSpecificitySystemic lupus erythematosus ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
ECHINOCOCCUS OF THE LUNGS.
Authors: CARL BECK
Journal: JAMA (1898)

1. Sciatica, often called a neuralgia, is generally a neuritis or a p9rineuritis.2. The pain in neuritis is due to the pressure on the nervi nervorum, and therefore nerve-stretching is very beneficial.3. Neuralgia, while it may occur in any part of the body, most commonly affects the fifth cranial nerve.4. Neuralgia in very many cases is associated with anemia.5. We should use electric treatment in cases of traumatic paralysis. 6. Antitetanic serum should be used as a protective agent in doubtful cases.7. The mortality in tetanus will be very much lowered in the future.
Effects of budesonide and fluticasone propionate in a placebo‐controlled study on symptoms and quality of life in seasonal allergic rhinitis
Authors: G. Ciprandi, W. G. Canonica, M. Grosclaude, J. Ostinelli, G. G. Brazzola, J. Bousquet
Journal: Allergy (2002)

Background: Intranasal glucocorticosteroids are effective in seasonal allergic rhinitis. This study compared the efficacy of budesonide (Rhinocort ®Turbuhaler®) and fluticasone propionate (Flixonase®) in this respect. Methods: Patients ( n = 280) were randomized to receive budesonide, 140 µg (delivered dose) once daily, fluticasone, 200 µg once daily, or matching placebos for 5 weeks. The primary efficacy variable was the change in combined nasal symptom (nasal blockage, runny nose, sneezing) scores. Quality of life was measured in 121 patients by means of the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and the Short‐form Health Survey (SF‐36). Results: Both steroids significantly reduced combined nasal symptoms, compared with placebo. There was no significant difference between the two treatments. Substantial or total symptom control was achieved in 89.9% of the budesonide‐treated patients, compared with 88.7% with fluticasone and 42.7% with placebo. Four of the five domains of the RQLQ were significantly improved with budesonide, whereas with fluticasone only two domains were improved. Budesonide significantly improved scores in five out of eight domains of the SF‐36, whereas no domains were improved with fluticasone. Conclusion: There was no significant difference in efficacy between budesonide and fluticasone in this study. However, greater improvements in quality of life were seen with budesonide than with fluticasone.
A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia
Authors: Gary A. Bellus, Iain McIntosh, E. Anne Smith, Arthur S. Aylsworth, Ilkka Kaitila, William A. Horton, Giselle A. Greenhaw, Jacqueline T. Hecht, Clair A. Francomano
Journal: Nature Genetics (1995)
Lisa Joan Fook
Authors: D. Fook, N. Carroll
Journal: BMJ (2008)

Lisa Joan Fook was the first born of Joan and Gerry Fook on the 2 June 1967 at Oxford Street Maternity Hospital, Liverpool. When only 7 weeks old she was cared for by her maternal aunt, as her mother was suffering from puerperal psychosis and required essential treatment.

Lisa was a mischievous child—whizzing around in her baby walker and frightening relatives into thinking she was going to fall down the stairs. However, she was very skilled and able to manoeuvre herself around the house safely.

At 16 months Lisa’s sister Dawn was born. She loved having a younger sister and would often speak on her behalf. When almost 7, Lisa’s second sibling, Kerry, was born whom she adored instantly. Lisa was a devoted sister from the onset and would always ensure the safety and support of her siblings as well as the rest of her family as a priority.

It was evident from a young age Lisa possessed extraordinary skills. Her ability to read and recite much of what she absorbed was tremendous. By the age of 7 she was familiar with the Pears young encyclopaedia, able to name all the capitals, highest mountains, and longest rivers in the world. She enjoyed playing chess with her father, and later with her siblings.

At the age of 8 Lisa was involved in a road traffic accident, resulting in several days hospitalisation and a distinctive scar over her left eye. While very scary for Lisa, it also assisted her to consider the consequences of events and live for every moment as the future is so unpredictable.

At school she was bright and outgoing. She enjoyed sports and was able to socialise easily with other children, some of whom she remained close to throughout her life. Lisa attended St Gregory’s infant and junior …
From doctor to carer: mission impossible?
Authors: A. H Knight
Journal: BMJ (2009)

“You just need to be the carer now . . . and you have to stop being a doctor.” A wry half smile of compassion accompanied the earnest gaze of our general practitioner as the three of us sat discussing the details of Sheila’s care and the part in the plan that I hoped to be able to fulfil myself. It is now one year since my wife died from cancer, and I wonder if I ever managed to make that transition. Had I been able to give up being the doctor in our family and become the essential carer? Throughout that precious time of caring, filled with a mixture of anxiety, emotion, and physical exhaustion, there remained that dilemma. How well was I doing at my job as carer, and how successful was I at dumping the doctor within me?

Four years earlier Sheila had undergone an emergency laparotomy for peritonitis from a perforated diverticulitis. I sat watching the monitor screens, all too aware of possible postoperative disasters. …
Phenol topically applied to canine left ventricular epicardium interrupts sympathetic but not vagal afferents.
Authors: M J Barber, T M Mueller, B G Davies, D P Zipes
Journal: Circulation Research (1984)

The intracardiac pathways carrying the cardiovascular reflex responses mediated by cardiac sympathetic and vagal afferent fibers were examined in this study. We investigated the response to epicardial applications of bradykinin (5 micrograms) and nicotine (50 micrograms) before and after regional epicardial applications of 85% phenol in chloralose anesthetized open-chest dogs. Bradykinin stimulated sympathetic afferents, while nicotine stimulated vagal afferents. Topical applications of phenol were used to interrupt these pathways. Before phenol encircling, bradykinin significantly increased--whereas nicotine significantly decreased--mean arterial blood pressure when applied at the same sites. After phenol, nicotine applied to all sites within and outside the phenol circle continued to decrease mean arterial pressure, whereas bradykinin applied to sites within the circle no longer increased mean arterial pressure. Removal of aortic and carotid baroreceptors did not significantly affect these responses. Painting horizontal stripes of phenol on the anterior and posterior left ventricular free wall basal to the site of bradykinin application eliminated the elevation in mean arterial pressure produced by bradykinin. Reapplication of bradykinin basal to the stripe restored its response. Phenol stripes eliminated the nicotine vasodepressor response only when the stripe was painted in the atrioventricular groove. When bradykinin and nicotine were injected via a nonocclusive intracoronary catheter, both drugs elicited an early depressor response (interrupted by vagotomy) and, in some animals a late pressor response (interrupted by stellectomy). Epicardial phenol encircling the flow distribution of the cannulated coronary artery interrupted most or all of the sympathetic afferents mediating pressor responses to bradykinin or nicotine, while leaving the depressor responses intact. The depressor responses were eliminated by applying phenol to the atrioventricular groove or by transecting the cervical vagi. These data suggest that sympathetic afferent fibers travel in the superficial subepicardium in an apex-to-base direction. Vagal afferent fibers travel deeper in the myocardium until they approach the atrioventricular groove, where they ascend to the superficial subepicardium.
Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix
Authors: Hermelita Winter, Mike A. Rogers, Lutz Langbein, Howard P. Stevens, Irene M. Leigh, Christine Labrèze, Sylvie Roul, Alain Taieb, Thomas Krieg, Jürgen Schweizer
Journal: Nature Genetics (1997)
Unusual Finding of Benign Abrikossoff Tumor by F-18 FDG-PET Mimicking Melanoma Recurrence
Authors: Roberto Di Cicilia, Paolo Castellucci, Margherita Nannini, Tiziana Balbi, Guido Zannetti, Stefano Fanti, Guido Biasco, Maria Abbondanza Pantaleo
Journal: Clinical Nuclear Medicine (2009)

Granular cell tumor of Abrikossoff is a rare neoplasm that may occur in a wide variety of cutaneous and visceral sites. Granular cell tumor generally shows benign behavior. However, malignant outcome with metastatic spread has also been reported. Until now, no data were available on the most useful imaging approach for diagnosis and staging. We present a case of F-18 fluorodeoxyglucose positron emission tomography in Abrikossoff tumor, suggesting that F-18 fluorodeoxyglucose positron emission tomography may have a potential role in the management of this neoplasm.
Granulocyte-macrophage colony-stimulating factor enhances wound healing in diabetes via upregulation of proinflammatory cytokines
Authors: Y. Fang, J. Shen, M. Yao, K.W. Beagley, B.D. Hambly, S. Bao
Journal: British Journal of Dermatology (2009)

Summary Background Chronic ulceration, especially in diabetes, remains a substantial clinical problem. Exogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) is efficacious in the treatment of chronic wound healing in both animal models and patients, but its role in diabetic wounds remains to be explored. Objectives Using a diabetic mouse model, to investigate the role of GM-CSF in wound healing. Methods Clinical observation, histopathology, immunohistochemistry and cytokine assays. Results There was a significant reduction (50%) in GM-CSF production in the wounds of the diabetics compared with nondiabetics. Exogenous GM-CSF substantially enhanced the wound healing in diabetic mice, accompanied by increased interleukin-6 and monocyte chemoattractant protein-1 production. The elevated cytokines correlated with increased neovascularization, and infiltration of macrophages and neutrophils. GM-CSF showed no beneficial effects in nondiabetic wound healing. Conclusions Our results provide useful guidelines for the clinical management of chronic ulceration in diabetes.
T cell–depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin
Authors: Ann A. Jakubowski, Trudy N. Small, James W. Young, Nancy A. Kernan, Hugo Castro-Malaspina, Katherine C. Hsu, Miguel-Angel Perales, Nancy Collins, Christine Cisek, Michelle Chiu, Marcel R. M. van den Brink, Richard J. O'Reilly, Esperanza B. Papadopoulos
Journal: Blood (2007)
Colonel Hoagland replies in the letter which follows
Authors: Robert J. Hoagland
Journal: JAMA (1963)

The low incidence of BFP reactions in mononucleosis was explained. The reason given by Dr. Kostant was given by me; additional explanations were inadequate criteria for diagnoses and excessive importance given to isolated case reports. My purpose was to debunk the cliché that BFP reactions occur frequently in mononucleosis. There was no intent to compare the frequency of false reactions in different serologic tests. My use of modern tests does not invalidate my conclusion: that it is time to expunge the fallacy of the frequently occurring BFP from the lore of mononucleosis.
A5-03: Correlative study of EGFR mutations or protein expressions of EGFR, phosphorylated EGFR, HER2, phosphorylated HER2 and IGFR-1 with gefitinib sensitivity in patients with non-small cell lung cancer: Results of West Japan Thoracic Oncology Group trial (WJTOG0203A)
Authors: Akihito Kubo, Kazuhiko Nakagawa, Tatsuhiko Kashii, Tomonori Hirashima, Jiichiro Sasaki, Kaoru Tanaka, Shigeki Sato, Takayasu Kurata, Kenji Tamura, Masahiro Fukuoka
Journal: Journal of Thoracic Oncology (2007)
Association between anaemia and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP): Findings from the Heart and Soul Study
Authors: Arati S. Desai, Kirsten Bibbins‐Domingo, Michael G. Shlipak, Alan H.B. Wu, Sadia Ali, Mary A. Whooley
Journal: European Journal of Heart Failure (2007)