Ankylosing Spondylitis, Hyperuricemia, and Anomalies of the Lumbosacral Junction
Authors: GEORGE R. THOMPSON
Journal: Annals of Internal Medicine (1963)

Article1 December 1963Ankylosing Spondylitis, Hyperuricemia, and Anomalies of the Lumbosacral JunctionA Family StudyGEORGE R. THOMPSON, M.D., WILLIAM MARTEL, M.D., MILOVAN T. RAKIC, M.D., JOHN T. HAYES, M.D.GEORGE R. THOMPSON, M.D.Search for more papers by this author, WILLIAM MARTEL, M.D.Search for more papers by this author, MILOVAN T. RAKIC, M.D.Search for more papers by this author, JOHN T. HAYES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-848 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThat genetic factors exist in ankylosing spondylitis is generally accepted. Several reports (1, 2) have suggested that this disease is inherited as if due to an autosomal dominant gene with variable penetrance, being manifest much more frequently in the male. While this seems to be true in some instances, in others it would appear that the heredity is more complex and is the result of several genetic factors (3, 4).It has also been suggested that hyperuricemia and gout are inherited as autosomal dominant characteristics with variable penetrance (5-7), with clinical manifestations occurring more frequently in males than in females....References1. HERSHSTECHERSOLOMONWOLPAWHANSEN AHRMWMRH: Heredity in ankylosing spondylitis: a study of fifty families. Amer. J. Hum. Genet. 2: 391, 1950. MedlineGoogle Scholar2. GRAHAMUCHIDA WJA: Heredity in ankylosing spondylitis. Ann. Rheum. Dis. 16: 334, 1957. CrossrefMedlineGoogle Scholar3. RIECKERNEELTEST HHJVA: The inheritance of spondylitis rhizomelique (ankylosing spondylitis) in the K. family. Ann. Intern. Med. 33: 1254, 1950. LinkGoogle Scholar4. DEBLECOURTPOLMANDEBLECOURT-MEINDERSMA JJAT: Hereditary factors in rheumatoid arthritis and ankylosing spondylitis. Ann. Rheum. Dis. 20: 215, 1961. CrossrefMedlineGoogle Scholar5. SMYTHCOTTERMANFREYBERG CJCWRH: The genetics of gout and hyperuricemia—an analysis of nineteen families. J. Clin. Invest. 27: 749, 1948. CrossrefGoogle Scholar6. STECHERHERSHSOLOMON RMAHWM: The heredity of gout and its relationship to familial hyperuricemia. Ann. Intern. Med. 31: 595, 1949. LinkGoogle Scholar7. SMYTH CJ: Heredity factors in gout (a review of recent literature). Metabolism 6: 218, 1957. MedlineGoogle Scholar8. HAUGEHARVALD MB: Heredity in gout and hyperuricemia. Acta. Med. Scand. 152: 247, 1955. CrossrefMedlineGoogle Scholar9. SEEGMILLERGRAYZELLASTERLIDDLE JEAILL: Uric acid production in gout. J. Clin. Invest. 40: 1304, 1961. CrossrefMedlineGoogle Scholar10. ALEPAHOWELLSEEGMILLER FPRRJE: The occurrence of glycogen storage disease with tophaceous gout. Arthritis Rheum. 5: 634, 1962. Google Scholar11. ANSELLBYWATERSLAWRENCE BMEGJS: A family study in Still's disease. Ann. Rheum. Dis. 21: 243, 1962. CrossrefMedlineGoogle Scholar12. BOLANDPRESENT EWAJ: Rheumatoid spondylitis: a study of one hundred cases with special reference to diagnostic criteria. JAMA 129: 843, 1945. CrossrefGoogle Scholar13. HOLLANDER JL: Arthritis and allied conditions, Lea and Febiger Company, Philadelphia, p. 861, 1960. Google Scholar14. NATHANKUBOTATURNBULL LACKGC: Relative incidence of gout in Negro and white males at Cook County Hospital (1944-1952). J. Lab. Clin. Med. 42: 927, 1953. Google Scholar15. CECIL RL: Influential factors in recovery from rheumatoid arthritis. Ann. Intern. Med. 8: 315, 1934. LinkGoogle Scholar16. ALLENROGERSLANSBURY GEFBJ: Osteogenesis imperfecta tarda with hyperuricemia and gout. Amer. J. Med. Sci. 230: 30, 1955. CrossrefMedlineGoogle Scholar17. WOLFSONLEVINETINSLEY WQRM: The transport and excretion of uric acid in man. I. True uric acid in normal cerebrospinal fluid, in plasma, and in ultrafiltrates of plasma. J. Clin. Invest. 26: 991, 1947. CrossrefGoogle Scholar18. KELLGREN JH: Diagnostic criteria for population studies. Bull. Rheum. Dis. 13: 291, 1962. MedlineGoogle Scholar19. HELLMAN L: Production of acute gouty arthritis by adrenocorticotropin. Science 109: 280, 1949. CrossrefMedlineGoogle Scholar20. ROBINSONCONNBLOCKLOUISKATZ WDJWWDLHJ: Gout: The Role of the Anterior Pituitary and the Adrenal Cortex in Urate Metabolism and in Gout. Proceedings 7th International Congress on Rheumatic Diseases, W. B. Saunders Company, Philadelphia, 1952, p. 241. Google Scholar21. KERSLEYMANDELJEFFREY GDLMR: Gout—an unusual case with softening and subluxation of the first cervical vertebra and splenomegaly. Ann. Rheum. Dis. 9: 283, 1950. CrossrefGoogle Scholar22. HALLSELIN MCG: Spinal involvement in gout—a case report with autopsy. J. Bone Joint Surg. 42-A; 341, 1960. CrossrefGoogle Scholar23. DESEZESALOFF SJ: Les anomalies transitionnelles de la charniere lombo-sacree. Lo Stetoscopio 5: 333, 1951. Google Scholar24. STINCHFIELDSINTON FEWA: Clinical significance of the transitional lumbosacral vertebra, relationship to back pain, disc disease, and sciatica. JAMA 157: 1107, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the Departments of Internal Medicine, Radiology, and Orthopedic Surgery, and the Rackham Arthritis Research Unit, The University of Michigan, Ann Arbor, Michigan.This work was supported in part by the Michigan Arthritis Research Grant from the Michigan Chapter of the Arthritis and Rheumatism Foundation and by training grant 2A 5026 from the United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to George R. Thompson, M.D., 1400 Traver Road Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1963Volume 59, Issue 6Page: 848-858KeywordsAnkylosing spondylitisArthritisAutosomal dominant diseasesGeneticsHeredityMedical servicesOrthopedic surgeryResearch grantsSpineSpondylitis Issue Published: 1 December 1963 PDF DownloadLoading ...