tbuckley/cabot-search huggingface dataset:
Elevated C Reactive Protein (CRP) is associated with a higher risk of thrombotic occlusion and poorer flow following percutaneous coronary intervention in patients with acute coronary syndromes: a TACTICS TIMI 18 angiographic substudy
Authors: Michael Gibson, David Morrow, Ralph Vicari, Graham Wong, Laura Demopolous, Peter DiBattiste, Sabina A. Murphy, Christopher P. Cannon, Eugene Braunwald
Journal: Journal of the American College of Cardiology (2002)
The Hebbian paradigm reintegrated: Local reverberations as internal representations
Authors: Daniel J. Amit
Journal: Behavioral and Brain Sciences (1995)

Abstract The neurophysiological evidence from the Miyashita group's experiments on monkeys as well as cognitive experience common to us all suggests that local neuronal spike rate distributions might persist in the absence of their eliciting stimulus. In Hebb's cell-assembly theory, learning dynamics stabilize such self-maintaining reverberations. Quasi-quantitive modeling of the experimental data on internal representations in association-cortex modules identifies the reverberations (delay spike activity) as the internal code (representation). This leads to cognitive and neurophysiological predictions, many following directly from the language used to describe the activity in the experimental delay period, others from the details of how the model captures the properties of the internal representations.
Comparison of Dermatophagoides pteronyssinus allergens from culture medium extract and whole body extract by using the same probe of pooled human serum
Authors: T. Abe, A. Ishii
Journal: Allergy (1987)

Two distinct allergens of Dermatophagoides pteronyssinus were isolated from culture medium extract and whole body extract monitored by the same probe of pooled human serum and compared. IgE‐binding activity of allergens from the two sources was detected by microplate‐ELISA with the same probe throughout the column chromatography. An allergen obtained from culture medium extract (Ag‐CME) had a molecular weight of 27,000 by SDS‐polyacrylamide gel electrophoresis (PAGE) and two isoelectric point ranges, pI 4.0–4.7 and 5.9–6.8. Another allergen from whole body extract (Ag‐WBE) had a molecular weight of 15,000 by SDS‐PAGE and an isoelectric point range, pI 4.8–5.3. Ag‐CME and Ag‐WBE are probably the same allergens as antigen P1 and DpX, respectively.
Activation of peroxisome proliferator-activated receptor-γ coactivator 1α ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury
Authors: Yanggang Yuan, Songming Huang, Wenyan Wang, Yingying Wang, Ping Zhang, Chunhua Zhu, Guixia Ding, Bicheng Liu, Tianxin Yang, Aihua Zhang
Journal: Kidney International (2012)
Adverse reactions to intravascular contrast agents
Authors: Peter Dawson
Journal: BMJ (2006)

<h3>Background</h3> To develop preliminary classification criteria for the cryoglobulinaemic syndrome or cryoglobulinaemic vasculitis (CV). <h3>Methods</h3> Study part I developed a questionnaire for CV to be included in the formal, second part (study part II). Positivity of serum cryoglobulins was defined by experts as an essential condition for CV classification. In study part II, a core set of classification items (questionnaire, clinical and laboratory items, as agreed) was tested in three groups of patients and controls—that is, group A (new patients with the CV), group B (controls with serum cryoglobulins but lacking CV) and group C (controls without serum cryoglobulins but with features which can be observed in CV). <h3>Results</h3> In study part I (188 cases, 284 controls), a positive response to at least two of three selected questions showed a sensitivity of 81.9% and a specificity of 83.5% for CV. This questionnaire was employed and validated in study part II, which included 272 patients in group A and 228 controls in group B. The final classification criteria for CV, by pooling data from group A and group B, required the positivity of questionnaire plus clinical, questionnaire plus laboratory, or clinical plus laboratory items, or all the three, providing a sensitivity of 88.5% and a specificity of 93.6% for CV. By comparing data in group A versus group C (425 controls), the same classification criteria showed a sensitivity 88.5% and a specificity 97.0% for CV. <h3>Conclusion</h3> Classification criteria for CV were developed, and now need validation.
Interim guidelines for management of abnormal cervical cytology. The 1992 National Cancer Institute Workshop
Authors: R. J. Kurman
Journal: JAMA (1994)

THE INCIDENCE of and mortality from cervical cancer in the United States have decreased dramatically over the past 40 years, in part because of early diagnosis and treatment of cervical cancer precursor lesions. The success of cervical cytological screening has served as a model for early diagnosis of other types of cancer. Although numerous studies have shown that lack of cytological screening is a major risk factor for the development of invasive cervical cancer,<sup>1-3</sup>it is important to emphasize that none of the screening, diagnostic, or therapeutic techniques used in medicine are perfect.<i>Accordingly, a few women will develop cervical cancer despite adherence to accepted screening protocols</i>. In addition, problems inherent with sampling, interpretation, and effective clinical follow-up preclude total prevention of cervical cancer. In recent years it has become evident that the cost and morbidity associated with the detection and treatment of low-grade cervical lesions have escalated, probably
The case for closer cooperation between local authorities and the NHS
Authors: D J Hunter
Journal: BMJ (1995)

for administering publicly funded health services.Although this course was not followed in 1948, it is important to remember that the argument for the local government alternative resurfaced during the 1974 reorganisation.Once again the local government option was rejected, but less decisively and with much less confidence in the rival schemes.By 1974 the traditional arguments against local government control of the health services were no longer tenable.Reorganised local government was generally suitable for this responsibility; there was no longer a requirement for local services to be predominantly locally funded; and the medical profession had largely, although not entirely, forgotten its distaste for local councils.Although it would be naive to assert that local government control of the health services would have been trouble free, it might well have provided a more stable basis for the health service than was offered by its rivals.The experience of nearly fifty years suggests that all attempts to arrive at viable alternative forms of administration outside local government have resulted in failure, forcing us yet again to contemplate fundamental readjustments in the health service.It would be a serious mistake to embark on commitments to further change without taking account of the strength of the argument for a much greater degree of integration between local governnent and the health services.
Resolution of nicotinic acid-induced acanthosis nigricans by substitution of an analogue (acipimox) in a patient with type V hyperlipidaemia
Authors: P. COATES, D. SHUTTLEWORTH, A. REES
Journal: British Journal of Dermatology (1992)

A patient with type V hyperlipidaemia is described, who developed acanthosis nigricans when treated with nicotinic acid and in whom resolution of the skin lesions and successful lipid control was achieved with an analogue of nicotinic acid (acipimox).
Patient-Centered Performance Management
Authors: Eve A. Kerr, Rodney A. Hayward
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy of Paroxysmal Pulmonary Edema by Antifoaming Agents
Authors: ALDO A. LUISADA
Journal: Circulation (1950)

Inhalation of certain volatile substances decreases the amount of foam in the respiratory passages and may be helpful in acute pulmonary edema. Experiments with several agents were performed in animals with different types of acute edema of the lungs. The best results were obtained with ethyl alcohol, which decreased the severity of the edema and prolonged the survival of the animals. Alcohol, while acting as an antifoaming agent, has no untoward side effects and is well tolerated. This method of therapy is now undergoing clinical tests.
Pretreatment with platelet derived growth factor-BB modulates the ability of costochondral resting zone chondrocytes incorporated into PLA/PGA scaffolds to form new cartilage in vivo
Authors: C.H. Lohmann, Z. Schwartz, G.G. Niederauer, D.L. Carnes, D.D. Dean, B.D. Boyan
Journal: Biomaterials (2000)
Hepatic regeneration in the isolated perfused rat liver followed by liver transplantation
Authors: José Luiz De Godoy, Monique Fabre, Brigitte Cherruau, Maritza McIntyre, Olivier Soubrane, Didier Houssin, Jorge E. Cardoso
Journal: Hepatology (1998)

Controlling the S phase of the hepatocyte cell cycle would be of considerable help for stable retroviral foreign gene transfer. The aim of this article is to study hepatocyte regeneration during S phase in isolated, perfused rat liver followed by liver transplantation. Normal livers (G I: n = 7) were perfused with blood from normal rats for 6.1 ± 0.3 hours. Regenerating livers (G II; n = 7) obtained 18 hours after partial hepatectomy were perfused for 6.0 ± 0.3 hours with blood from rats partially hepatectomized 18 hours before. Regenerating livers (G III; n = 7) obtained 22 hours after partial hepatectomy were perfused for 2.4 ± 0.1 hours with blood from normal rats. In the normothermal perfusion system, a bolus of 25 mg of 5-bromo-2′-deoxyuridine (BrdU) was added to the perfusate. Liver biopsies were taken at the end of each experiment. In group II, a biopsy was also taken 1 hour after BrdU introduction. At the end of each experiment, livers were orthotopically transplanted. The percentage of BrdU positive hepatocyte nuclei was 0.2% in G I; 14.8% and 38.4% after 1 hour and 6.1 hours, respectively, in G II; and 46.5% after 2.4 hours in G III. In G I, five rats died at day 1, 5, 6, 7, and 48 and two rats were still alive after 17 months. In G II, all the rats died before day five. In G III, two rats died at day one, one at day six, and four were still alive after 12 months. This study shows that, after 6 hours of normothermal perfusion, organ viability allows successful liver transplantation and that rat hepatocyte regeneration during cell cycle S phase in isolated normothermal conditions progresses in a similar way-quantity and timing-to liver regeneration found in vivo after partial hepatectomy.
Integration of Cardiac Proteome Biology and Medicine by a Specialized Knowledgebase
Authors: Nobel C. Zong, Haomin Li, Hua Li, Maggie P.Y. Lam, Rafael C. Jimenez, Christina S. Kim, Ning Deng, Allen K. Kim, Jeong Ho Choi, Ivette Zelaya, David Liem, David Meyer, Jacob Odeberg, Caiyun Fang, Hao-jie Lu, Tao Xu, James Weiss, Huilong Duan, Mathias Uhlen, John R. Yates, Rolf Apweiler, Junbo Ge, Henning Hermjakob, Peipei Ping
Journal: Circulation Research (2013)

Rationale : Omics sciences enable a systems-level perspective in characterizing cardiovascular biology. Integration of diverse proteomics data via a computational strategy will catalyze the assembly of contextualized knowledge, foster discoveries through multidisciplinary investigations, and minimize unnecessary redundancy in research efforts. Objective : The goal of this project is to develop a consolidated cardiac proteome knowledgebase with novel bioinformatics pipeline and Web portals, thereby serving as a new resource to advance cardiovascular biology and medicine. Methods and Results : We created Cardiac Organellar Protein Atlas Knowledgebase (COPaKB; www.HeartProteome.org ), a centralized platform of high-quality cardiac proteomic data, bioinformatics tools, and relevant cardiovascular phenotypes. Currently, COPaKB features 8 organellar modules, comprising 4203 LC-MS/MS experiments from human, mouse, drosophila, and Caenorhabditis elegans , as well as expression images of 10 924 proteins in human myocardium. In addition, the Java-coded bioinformatics tools provided by COPaKB enable cardiovascular investigators in all disciplines to retrieve and analyze pertinent organellar protein properties of interest. Conclusions : COPaKB provides an innovative and interactive resource that connects research interests with the new biological discoveries in protein sciences. With an array of intuitive tools in this unified Web server, nonproteomics investigators can conveniently collaborate with proteomics specialists to dissect the molecular signatures of cardiovascular phenotypes.
Stress Incontinence Treated by Electrical Stimulation
Authors: S. A. Vincent
Journal: BMJ (1967)

arterial hypertension and right ventricular failure, and this may occur rapidly and therefore be seen when the patient still has pain.Elevation of the jugular venous pres- sure is therefore not a distinguishing point between pulmonary embolism and myocardial infarction, unless left ventricular failure can be confidently excluded.-Iam, etc.,
Inflammation and autoimmune responses are independent of peripheral MHC class II expression driven by CIITA pIV in collagen induced arthritis
Authors: J.-M. Waldburger, G. Palmer, C. Seemayer, C. Lamacchia, A. Finckh, P. Christofilopoulos, D. Baeten, W. Reith, C. Gabay
Journal: Annals of the Rheumatic Diseases (2011)

<h3>Background</h3> In rheumatoid arthritis (RA), non-professional antigen presenting cells (APCs) such as fibroblast-like synoviocytes (FLS) can express MHC class II (MHCII) molecules and function as non-professional APCs in vitro. <h3>Objective</h3> To examine the regulation of MHCII expression in FLS and to investigate the role of FLS as non-professional APCs in collagen-induced arthritis (CIA). <h3>Methods</h3> Expression of MHCII, CIITA and Ciita isoforms pI, pIII and pIV was examined by RT-qPCR, immunohistochemistry and flow cytometry in human synovial tissues, arthritic mouse joints and human as well as mouse FLS. CIA was induced in mice knockout for the isoform IV of Ciita (pIV-/-), in pIV-/- mice transgenic for CIITA in the thymus (pIV-/- K14 CIITA) and in control littermates in the DBA/1 background by immunising with bovine collagen type II (CII) in complete Freund9s adjuvant. <h3>Results</h3> HLA-DRA, total CIITA and CIITA pIII mRNA levels were significantly increased in the synovial tissues from RA compared to osteoarthritis patients. Human FLS expressed surface MHCII via CIITA pIII and pIV, while MHCII expression in murine FLS was entirely mediated by pIV. pIV-/- mice lacked both inducible MHCII expression on non-professional APCs including FLS, and in the thymic cortex. The thymic defect in pIV-/- mice impaired CD4+ positive selection, thus protecting pIV-/- mice from CIA by preventing CD4+ T cells immune responses against CII and blocking the release of IFN-γ and IL-17 in ex vivo stimulated lymph node cells. The production of T dependent, arthritogenic anti-CII antibodies was also impaired in pIV-/- mice. A normal thymic expression of MHCII and CD4+ T cell repertoire was obtained in pIV-/- K14 CIITA Tg mice. Immune responses against CII were restored in pIV-/- K14 CIITA Tg mice, as well as the arthritis incidence and clinical severity despite the lack of MHCII expression by mouse FLS. At histology, inflammation and neutrophils infiltration scores were not reduced in pIV-/- K14 CIITA Tg mice, while the bone erosion score was significantly lower than in controls. <h3>Conclusion</h3> Over expression of MHCII is tightly correlated with CIITA pIII in the arthritic human synovium. MHCII is induced via CIITA pIII and pIV in human FLS. In the mouse, MHCII expression in the thymic cortex and in FLS is strictly dependent upon Ciita pIV. The lack of Ciita pIV in the periphery of pIV-/- K14 CIITA Tg mice lowered the bone erosion score but did not significantly protect from inflammation and autoimmune responses in CIA. <h3>Funding</h3> Supported by grants from the Albert Böni foundation (to JMW), Carlos et Elise de Reuters foundation (to JMW), and the Swiss National Science Foundation (grant No 310030_122477 to JMW; No 320000-119728 to CG; No 320000-120319 (to GP).
Evaluation of Diffusion-Weighted Magnetic Resonance Imaging for Follow-up and Treatment Response Assessment of Lymphoma: Results of an 18F-FDG-PET/CT–Controlled Prospective Study in 64 Patients
Authors: Marius E. Mayerhoefer, Georgios Karanikas, Kurt Kletter, Helmut Prosch, Barbara Kiesewetter, Cathrin Skrabs, Edit Porpaczy, Michael Weber, Thomas Knogler, Christian Sillaber, Ulrich Jaeger, Ingrid Simonitsch-Klupp, Philipp Ubl, Leonhard Müllauer, Werner Dolak, Julius Lukas, Markus Raderer
Journal: Clinical Cancer Research (2015)

To determine the value of diffusion-weighted MRI (DWI-MRI) for treatment response assessment in 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-avid lymphoma.Patients with FDG-avid Hodgkin (HL) or non-Hodgkin lymphoma (NHL) at pretherapeutic 18F-FDG-PET/CT, who had also undergone pretherapeutic whole-body DWI-MRI, were included in this prospective study. Depending on the histologic lymphoma subtype, patients received different systemic treatment regimens, and follow-up DWI-MRI and 18F-FDG-PET/CT were performed at one or more time points, depending on the clinical course. For each follow-up DWI-MRI, region-based rates of agreement, and rates of agreement in terms of treatment response (complete remission, partial remission, stable disease, or progressive disease), relative to the corresponding 18F-FDG-PET/CT, were calculated.Sixty-four patients were included: 10 with HL, 22 with aggressive NHL, and 32 with indolent NHL. The overall region-based agreement of DWI-MRI with 18F-FDG-PET/CT was 99.4%. For the 51 interim examinations (performed after 1-3 therapy cycles), region-based agreement of DWI-MRI with 18F-FDG-PET/CT was 99.2%, and for the 48 end-of-treatment examinations, agreement was 99.8%. No significant differences, in terms of region-based agreement between DWI-MRI and 18F-FDG-PET/CT, were observed between the three lymphoma groups (HL, aggressive NHL, indolent NHL; P = 0.25), or between interim and end-of-treatment examinations (P = 0.21). With regard to treatment response assessment, DWI-MRI agreed with 18F-FDG-PET/CT in 99 of 102 follow-up examinations (97.1%), with a κ value of 0.94 (P < 0.0001).In patients with FDG-avid lymphoma, DWI-MRI may be a feasible alternative to 18F-FDG-PET/CT for follow-up and treatment response assessment.
The New Zealand rugby injury and performance project. III. Anthropometric and physical performance characteristics of players.
Authors: K L Quarrie, P Handcock, A E Waller, D J Chalmers, M J Toomey, B D Wilson
Journal: British Journal of Sports Medicine (1995)

OBJECTIVE: To investigate the anthropometric and physical performance characteristics of New Zealand rugby players of different ages and both sexes. METHODS: 356 rugby players (264 male, 92 female) took part in the study during a single season. Playing grade ranged from schoolboys and schoolgirls to senior men and women. Assessment of height, weight, neck circumference, and somatotype was performed before the competitive rugby season. A battery of six physical performance assessments was completed after the anthropometry. Analysis of variance was used to examine differences in these variables between field positions and grades. RESULTS: Significant differences between forwards and backs on anthropometric and physical performance variables were apparent at all grades assessed. In terms of anthropometric characteristics, forwards of a given grade were generally taller, possessed greater body mass, and were more endomorphic and less ectomorphic than backs of the same grade. The backs tended to perform better on physical performance measures than forwards, being more aerobically fit, faster, more agile, and possessing a higher degree of muscular endurance. Differences in anthropometry and physical performance attributes were also apparent between players from the various grades. The players at higher levels were generally larger, and performed better on tests of physical performance than the players at lower levels. These differences were found in both sexes. CONCLUSIONS: The greater body mass of the forwards allows them to obtain greater momentum than the backs when sprinting. The ability to obtain greater momentum is important in the body contact phases of the game. Forwards may compromise their aerobic fitness and speed to some extent in order to maintain a high body mass. The anthropometric and physical performance characteristics of players appear to reflect the demands placed on them by the sport.
Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1
Authors: Matthew S. Goldberg, Antonio Pisani, Marian Haburcak, Timothy A. Vortherms, Tohru Kitada, Cinzia Costa, Youren Tong, Giuseppina Martella, Anne Tscherter, Andrea Martins, Giorgio Bernardi, Bryan L. Roth, Emmanuel N. Pothos, Paolo Calabresi, Jie Shen
Journal: Neuron (2005)