tbuckley/cabot-search huggingface dataset:
Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation
Authors: Younghun Jung, Jingcheng Wang, Junhui Song, Yusuke Shiozawa, Jianhua Wang, Aaron Havens, Zhuo Wang, Yan-Xi Sun, Stephen G. Emerson, Paul H. Krebsbach, Russell S. Taichman
Journal: Blood (2007)
Species heterogeneity in macrophage expression of the CD4 antigen.
Authors: P R Crocker, W A Jefferies, S J Clark, L P Chung, S Gordon
Journal: The Journal of Experimental Medicine (1987)

The CD4 antigen is expressed on T cells of all mammalian species examined and appears to play an important role in the response of T cells to antigen. In humans, the molecule acts as a receptor for the AIDS virus. Previous studies have demonstrated that M phi in the rat and human also express the CD4 antigen, which is indistinguishable from that on T cells. In this paper we demonstrate by FACS analysis, Northern blot hybridization, and immunoperoxidase labeling that, in striking contrast to the rat and human, mouse M phi do not express the CD4 (L3T4) antigen. This species heterogeneity indicates that T cells and M phi regulate CD4 antigen expression independently and that CD4 may not be essential for M phi function.
Processus de développement et processus thérapeutique
Authors: D.R. Henny
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 Processus de développement et processus thérapeutique Subject Area: Psychiatry and Psychology D.R. Henny D.R. Henny Office médico-pédagogique vaudois, Lausanne Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 65–69. https://doi.org/10.1159/000287102 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation D.R. Henny; Processus de développement et processus thérapeutique. Psychother Psychosom 31 December 1978; 29 (1-4): 65–69. https://doi.org/10.1159/000287102 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Long-term course of interferon-treated chronic hepatitis C
Authors: Calogero Cammà, Vito Di Marco, Oreste Lo Iacono, Piero Almasio, Marco Giunta, Patrizia Fuschi, Alessandra Vaccaro, Carmelo Fabiano, Silvio Magrin, Rosa Di Stefano, Celestino Bonura, Luigi Pagliaro, Antonio Craxì
Journal: Journal of Hepatology (1998)
Polychlorinated Biphenyls 105 and 118 Form Thyroid Hormone Receptor Agonists after Cytochrome P4501A1 Activation in Rat Pituitary GH3 Cells
Authors: Kelly J. Gauger, Stefanie Giera, David S. Sharlin, Ruby Bansal, Eric Iannacone, R. Thomas Zoeller
Journal: Environmental Health Perspectives (2007)

BackgroundPolychlorinated biphenyls (PCBs) may interfere with thyroid hormone (TH) signaling by reducing TH levels in blood, by exerting direct effects on TH receptors (TRs), or both.ObjectiveOur objective was to identify individual PCBs that directly affect TH signaling by acting on the TR.MethodsWe administered a mixture of six PCB congeners based on their ortho substitution pattern, including PCBs 77 and 126 (non-ortho), PCBs 105 and 118 (mono-ortho), and PCBs 138 and 153 (di-ortho), to pregnant Sprague-Dawley rats from gestational days (G) 6 to 16. This mixture, or various combinations of the components, was also evaluated in a transient transfection system using GH3 cells.ResultsThe mixture reduced serum TH levels in pregnant rats on G16 but simultaneously up-regulated the expression of malic enzyme in liver. It also functioned as a TR agonist in vitro; however, none of the individual PCB congeners comprising this mixture were active in this system. Using the aryl hydrocarbon receptor (AhR) antagonist α-naphthoflavone, and the cytochrome P450 (CYP)1A1 antagonist ellipticine, we show that the effect of the mixture on the thyroid hormone response element required AhR and CYP1A1.ConclusionsWe propose that PCB 126 induces CYP1A1 through the AhR in GH3 cells, and that CYP1A1 activates PCB 105 and/or 118 to a form a compound that acts as a TR agonist. These data suggest that some tissues may be especially vulnerable to PCBs interfering directly with TH signaling due to their capacity to express CYP1A1 in response to coplanar PCBs (or other dioxin-like molecules) if sufficient mono-ortho PCBs are present.
THE BETA-NAPHTHOL VS. HYDRO-NAPHTHOL CONTENTION.
Authors: JOHN V. SHOEMAKER
Journal: JAMA (1889)

"Who shall decide when doctors disagree?" says the poet, with as close accordance with a general truth as reason and poetry require. Yet we shall always find, even in the case of the disagreement of doctors, criteria by which rational decision may be reached. In the first place, the opinions of individual doctors, as well as of persons not doctors, are not of equal weight, as emanating from men of learning, conversant with the class of subjects under consideration, and qualified to be experimentally satisfied, if question of experiment there be, of the results which they have obtained. In the next place, personal feeling and pecuniary interest may enter into the determination of questions and, giving bias, place the decider of them in a non-judicial attitude of mind. Other things being equal, the fact of the majority, and that a large majority, on one side, is an element enabling an
Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
Authors: Hervé Avet-Loiseau, Florent Malard, Loic Campion, Florence Magrangeas, Catherine Sebban, Bruno Lioure, Olivier Decaux, Thierry Lamy, Laurence Legros, Jean-Gabriel Fuzibet, Mauricette Michallet, Bernadette Corront, Pascal Lenain, Cyrille Hulin, Claire Mathiot, Michel Attal, Thierry Facon, Jean-Luc Harousseau, Stephane Minvielle, Philippe Moreau
Journal: Blood (2010)
Controlled trial of biofeedback-aided behavioural methods in reducing mild hypertension.
Authors: C Patel, M G Marmot, D J Terry
Journal: BMJ (1981)

Employees of a large industry were screened for the presence of coronary risk factors. A total of 204 employees, aged 35-64 years, with two or more such factors (serum cholesterol concentration greater than or equal to 6.3 mmol/l (243.6 mg/100 ml), blood pressure greater than or equal to 140/90 mm Hg, and current cigarette consumption greater than or equal to 10 cigarettes a day) were randomly allocated to a biofeedback group receiving training in relaxation and management of stress or a control group. Both groups received simple health education literature. After eight weeks of training, and again eight months later, the biofeedback group showed a significantly greater fall in systolic and diastolic blood pressures than the control group (p less than 0.001). Plasma renin activity and plasma aldosterone concentration were measured in a subsample at entry to the study and again at eight weeks and eight months; both showed a greater reduction in the biofeedback compared with the control group at eight weeks' follow-up. The greater reduction in blood pressure in the subjects in the biofeedback group compared with the control group (11.0 mm Hg systolic and 8.8 mm Hg diastolic), persisting eight months after the training, suggests that relaxation-based behavioural methods might be offered as a first-time treatment to patients with mild hypertension.
Can Estrogen or Selective Estrogen-Receptor Modulators Preserve Cognitive Function in Elderly Women?
Authors: Richard Mayeux
Journal: New England Journal of Medicine (2001)

The use of estrogen-replacement therapy has been associated with a lower risk of Alzheimer's disease1 and preserved or enhanced cognitive performance in postmenopausal women.2 Despite the consistency of these observations, there are lingering doubts surrounding the observational studies of estrogen use. The failure to measure factors such as differences in the health-seeking behavior or socioeconomic status of women who choose to use or not to use estrogen has been an important limitation. It has therefore become important to conduct well-designed, controlled clinical trials of estrogen-replacement therapy for the treatment or prevention of cognitive impairment and dementia. More recently, selective estrogen-receptor . . .
Inconsistent Coding of Race and Ethnicity in Infants-Reply
Authors: Robert A. Hahn
Journal: JAMA (1992)

<h3>In Reply.</h3> —The purpose of our article was to examine inconsistencies in the coding of race and Hispanic ethnicity in infant birth and death certificates and to show the implications of inconsistent coding for the calculation of infant mortality rates.<sup>1</sup>We found that although 1.2% of infants coded as "white" at birth were coded with a different race at death and 4.3% of "black" infants at birth had a different race coded at death, 43.2% of infants coded with other races at birth were coded with different races at death. Japanese and Filipino infants were more likely to be coded with a different race than with the same race at death. Most infants whose race was inconsistently coded were coded as white at death. Racial classification at birth is most likely to be accurate; thus, we compared classifications at death with this standard. We believe that if an individual
Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: A longitudinal analysis
Authors: Mazen Noureddin, Elizabeth C. Wright, Harvey J. Alter, Shauna Clark, Emmanuel Thomas, Richard Chen, Xiongce Zhao, Cathy Conry-Cantilena, David E. Kleiner, Jake T. Liang, Marc G. Ghany
Journal: Hepatology (2013)

Interleukin (IL)28B polymorphisms are associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to therapy. Whether IL28B genotype affects fibrosis progression or clinical outcome is unclear. Our aim was to study the relationship between IL28B genotype and both histological and clinical outcomes in patients with chronic hepatitis C (CHC). Hepatic fibrosis was scored using the Ishak (0-6) scale; progression was defined as a 2-point increase in Ishak score between biopsies. Multiple logistic and Cox regressions were used to identify variables associated with fibrosis progression. In all, 1,483 patients were included in a baseline cross-sectional analysis, from which 276 were eligible for a paired biopsy analysis (median time between biopsies 4 years), and 400 for a clinical outcome analysis. At baseline biopsy, patients with IL28B CC genotype had significantly higher portal inflammation (2.4 versus 2.2) and alanine aminotransferase (ALT) levels (133 versus 105 U/L; P < 0.05 for all). In the paired biopsy analysis, there was no difference in the frequency of fibrosis progression between patients with IL28B CC and non-CC genotypes (17% versus 23%). In logistic regression, only higher baseline alkaline phosphatase, lower platelets, and greater hepatic steatosis were associated with fibrosis progression. Patients with IL28B CC were twice as likely to develop adverse clinical outcomes compared to non-CC (32% versus 16%; P = 0.007).
Influence of door-to-balloon time on mortality in primary angioplasty results in 3,648 patients in the second national registry of myocardial infarction (NRMI-2)
Authors: Christopher P. Cannon, Costas T. Lambrew, Alan J. Tiefenbrunn, William J. French, Joel M. Gore, Douglas Weaver, William J. Rogers
Journal: Journal of the American College of Cardiology (1996)
Clinical Endocrinology for Practitioners and Students
Authors: Frederick C. Goetz
Journal: JAMA (1965)

Many medical textbooks published recently in the United States consist of a series of detailed articles, each written by a different subspecialist. In this fourth edition of his text on clinical endocrinology, Dr. Martin (of Cambridge, England) chooses the other course—comprehensive coverage of a complex area of knowledge by one writer, who holds himself responsible for all aspects of his subject. (The only exception here is the chapter on the ovary, in which collaboration with a gynecologist is acknowledged.) On the whole, his effort is remarkably successful. The book, clearly intended as a practical handbook, places considerable emphasis on clinical diagnosis and treatment. However, relevant anatomy and physiology are systematically included. The style of writing is concise and has the advantage of consistency. The book is nicely printed, the format appealing and convenient. Handbooks such as this inevitably risk incompleteness and dogmatism. To some degree these faults are present here:
A Family Affair—Revisited
Authors: Alan D. Haber
Journal: Annals of Internal Medicine (2010)

On Being a Doctor4 May 2010A Family Affair—RevisitedAlan D. Haber, MDAlan D. Haber, MDFrom Fox Chase Cancer Center, Philadelphia, PA 19111.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-9-201005040-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Friday afternoon clinic was a classic rookie assignment, yet having completed my pulmonary fellowship 16 years ago I hardly felt like a newly minted physician. However, the changing winds of medical economics had shuttered the hospital where I had worked for 13 years and scattered the medical staff. I was fortunate to land at a prestigious and accommodating institution, but my former seniority carried little standing when it came to decisions of clinic space and time. My wife had hoped that someday soon I could change this assignment to be more available for family time on Friday evenings. Friday afternoon ... Author, Article, and Disclosure InformationAffiliations: From Fox Chase Cancer Center, Philadelphia, PA 19111.Corresponding Author: Alan D. Haber, MD, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111; e-mail, alan.[email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 May 2010Volume 152, Issue 9Page: 612-613KeywordsAcute respiratory distress syndromeChemotherapyChildrenDyspneaLung and intrathoracic tumorsLungsSurgeryTechniciansThoraxTransplantation ePublished: 4 May 2010 Issue Published: 4 May 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Integrating Primary Medical Care With Addiction Treatment
Authors: Constance Weisner, Jennifer Mertens, Sujaya Parthasarathy, Charles Moore, Yun Lu
Journal: JAMA (2001)

ContextThe prevalence of medical disorders is high among substance abuse patients, yet medical services are seldom provided in coordination with substance abuse treatment.ObjectiveTo examine differences in treatment outcomes and costs between integrated and independent models of medical and substance abuse care as well as the effect of integrated care in a subgroup of patients with substance abuse–related medical conditions (SAMCs).DesignRandomized controlled trial conducted between April 1997 and December 1998.Setting and PatientsAdult men and women (n = 592) who were admitted to a large health maintenance organization chemical dependency program in Sacramento, Calif.InterventionsPatients were randomly assigned to receive treatment through an integrated model, in which primary health care was included within the addiction treatment program (n = 285), or an independent treatment-as-usual model, in which primary care and substance abuse treatment were provided separately (n = 307). Both programs were group based and lasted 8 weeks, with 10 months of aftercare available.Main Outcome MeasuresAbstinence outcomes, treatment utilization, and costs 6 months after randomization.ResultsBoth groups showed improvement on all drug and alcohol measures. Overall, there were no differences in total abstinence rates between the integrated care and independent care groups (68% vs 63%, P = .18). For patients without SAMCs, there were also no differences in abstinence rates (integrated care, 66% vs independent care, 73%; P = .23) and there was a slight but nonsignificant trend of higher costs for the integrated care group ($367.96 vs $324.09, P = .19). However, patients with SAMCs (n = 341) were more likely to be abstinent in the integrated care group than the independent care group (69% vs 55%, P = .006; odds ratio [OR], 1.90; 95% confidence interval [CI], 1.22-2.97). This was true for both those with medical (OR, 3.38; 95% CI, 1.68-6.80) and psychiatric (OR, 2.10; 95% CI, 1.04-4.25) SAMCs. Patients with SAMCs had a slight but nonsignificant trend of higher costs in the integrated care group ($470.81 vs $427.95, P = .14). The incremental cost-effectiveness ratio per additional abstinent patient with an SAMC in the integrated care group was $1581.ConclusionsIndividuals with SAMCs benefit from integrated medical and substance abuse treatment, and such an approach can be cost-effective. These findings are relevant given the high prevalence and cost of medical conditions among substance abuse patients, new developments in medications for addiction, and recent legislation on parity of substance abuse with other medical benefits.
Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells
Authors: Christopher G. Kanakry, Allan D. Hess, Christopher D. Gocke, Christopher Thoburn, Ferdynand Kos, Christian Meyer, Janet Briel, Leo Luznik, B. Douglas Smith, Hyam Levitsky, Judith E. Karp
Journal: Blood (2010)
Low-Carbohydrate Diets and All-Cause and Cause-Specific Mortality
Authors: Teresa T. Fung
Journal: Annals of Internal Medicine (2010)

Background: Data on the long-term association between low-carbohydrate diets and mortality are sparse. Objective: To examine the association of low-carbohydrate diets with mortality during 26 years of follow-up in women and 20 years in men. Design: Prospective cohort study of women and men who were followed from 1980 (women) or 1986 (men) until 2006. Low-carbohydrate diets, either animal-based (emphasizing animal sources of fat and protein) or vegetable-based (emphasizing vegetable sources of fat and protein), were computed from several validated food-frequency questionnaires assessed during follow-up. Setting: Nurses' Health Study and Health Professionals' Follow-up Study. Participants: 85 168 women (aged 34 to 59 years at baseline) and 44 548 men (aged 40 to 75 years at baseline) without heart disease, cancer, or diabetes. Measurements: Investigators documented 12 555 deaths (2458 cardiovascular-related and 5780 cancer-related) in women and 8678 deaths (2746 cardiovascular-related and 2960 cancer-related) in men. Results: The overall low-carbohydrate score was associated with a modest increase in overall mortality in a pooled analysis (hazard ratio [HR] comparing extreme deciles, 1.12 [95% CI, 1.01 to 1.24]; P for trend = 0.136). The animal low-carbohydrate score was associated with higher all-cause mortality (pooled HR comparing extreme deciles, 1.23 [CI, 1.11 to 1.37]; P for trend = 0.051), cardiovascular mortality (corresponding HR, 1.14 [CI, 1.01 to 1.29]; P for trend = 0.029), and cancer mortality (corresponding HR, 1.28 [CI, 1.02 to 1.60]; P for trend = 0.089). In contrast, a higher vegetable low-carbohydrate score was associated with lower all-cause mortality (HR, 0.80 [CI, 0.75 to 0.85]; P for trend ≤ 0.001) and cardiovascular mortality (HR, 0.77 [CI, 0.68 to 0.87]; P for trend < 0.001). Limitations: Diet and lifestyle characteristics were assessed with some degree of error. Sensitivity analyses indicated that results were probably not substantively affected by residual confounding or an unmeasured confounder. Participants were not a representative sample of the U.S. population. Conclusion: A low-carbohydrate diet based on animal sources was associated with higher all-cause mortality in both men and women, whereas a vegetable-based low-carbohydrate diet was associated with lower all-cause and cardiovascular disease mortality rates. Primary Funding Source: National Institutes of Health.
NATIVE AFRICAN CHILD-MARRIAGE: ITS RELATION TO UTERINE DISEASE AND DIFFICULT PARTURITION.
Authors: ROBERT H. NASSAU
Journal: JAMA (1893)

The common impression that maternity is easy among nations uncivilized and consequently untrammeled by the restrictions of fashion and conventionality, is incorrect—certainly as to the tribes of Western Equatorial Africa. An acquaintance, based on a residence there of over thirty years, with native African customs and habits, has made it apparent to me that the sexual life of the native women is thereby marred, maternity made painful and often fatal, and diseases entailed that make their lives a burden. I have observed the following facts, which are fruitful sources of uterine disease and difficult parturition. 1. Women are taken in marriage at too early an age. Sexual connection is commonly had before the age of puperty. Under the polygamous customs of the country, little girls, even in infancy, are bargained for with their parents by suitors, each running a race, trying who shall first complete the sum of money demanded
Is active acid sphingomyelinase required for the antiproliferative response to rituximab?
Authors: Frédérique Sabourdy, Janick Selves, Leonardo Astudillo, Camille Laurent, Pierre Brousset, Marie-Bernadette Delisle, Nicole Therville, Nathalie Andrieu-Abadie, Bruno Ségui, Christian Recher, Thierry Levade
Journal: Blood (2011)
Portraits aim to highlight women's contribution to surgery
Authors: L. Eaton
Journal: BMJ (2008)

A series of portraits of women surgeons by the Edinburgh based artist Jane Brettle have gone on show at the Royal College of Surgeons of England. The commissions are intended to raise awareness of the profile of women in surgery.

“These inspirational women are fantastic role models which female medical students can aspire to,” said Helen Fernandes, consultant neurosurgeon and chairwoman of …