Low-Level Teicoplanin Resistance and Heteroresistance to Vancomycin
Authors: Krzysztof Sieradzki
Journal: Annals of Internal Medicine (1998)

Letters1 February 1998Low-Level Teicoplanin Resistance and Heteroresistance to VancomycinKrzysztof Sieradzki, Paolo Villari, and Alexander TomaszKrzysztof SieradzkiThe Rockefeller University; New York, NY 10021Search for more papers by this author, Paolo VillariThe Rockefeller University; New York, NY 10021Search for more papers by this author, and Alexander TomaszThe Rockefeller University; New York, NY 10021Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-3-199802010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Concern about the appearance of glycopeptide resistance among staphylococci prompted us to examine 41 methicillin-resistant coagulase-negative staphylococcal clinical isolates recovered in a New York City hospital during a 5-month period between September 1995 and February 1996. Twenty-eight of 41 strains showed elevated teicoplanin MICs (8 to 32 µg/mL), and all 6 strains examined in more detail by population analysis profiles [1] also exhibited heteroresistance to vancomycin: Dense cultures contained bacteria with low frequencies (10−5 to 10−7) that could grow at 12 µg of the antibiotic per mL [2]. Pulsed-field gel electrophoresis showed that the 28 isolates represented ...References1. Tomasz A, Nachman S, Leaf H. Stable classes of phenotypic expression in methicillin resistant clinical isolates of staphylococci. Antimicrob Agents Chemother. 1991; 35:124-9. Google Scholar2. Sieradzki K, Villari P, Tomasz A. Decreased susceptibility to teicoplanin and vancomycin among coagulase-negative methicillin-resistant clinical isolates of staphylococci. Antimicrob Agents Chemother. [In press]. Google Scholar3. Sieradzki K, Tomasz A. Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus. J Bacteriol. 1997; 179:2557-66. Google Scholar4. Staphylococcus aureus with reduced susceptibility to vancomycin-United States, 1997. MMWR Morb Mortal Wkly Rep. 1997; 46:765-6. Google Scholar5. Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC. Methicillin resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Agents Chemother. 1997; 40:135-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: The Rockefeller University; New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByManagement of Multi-Drug Resistant Methicillin Resistant Staphylococcus aureus Induced Pneumonia with New Antibiotic Adjuvant Entity: A Retrospective StudyMinimum inhibitory concentration (MIC) of crude preparations of Brevibacillus laterosporus SA14 bioactive material compared to vancomycin and oxacillin, against clinical isolates of methicillin-resistant Staphylococcus aureusLinezolid versus Vancomycin for the Treatment of Methicillin‐Resistant Staphylococcus aureus InfectionsLow-level resistance to glycopeptides amongst staphylococcus species: Surveillance in a university hospital and evaluation of a vancomycin screening agarActivities of LY333328 and Vancomycin Administered Alone or in Combination with Gentamicin against Three Strains of Vancomycin-Intermediate Staphylococcus aureus in an In Vitro Pharmacodynamic Infection ModelActivities of Trovafloxacin and Ampicillin-Sulbactam Alone or in Combination versus Three Strains of Vancomycin- Intermediate Staphylococcus aureus in an In Vitro Pharmacodynamic Infection ModelAntimicrobial resistance in Staphylococcus aureus 1 February 1998Volume 128, Issue 3Page: 245KeywordsBacteriaDNADrugsExcretionMethicillin-resistant Staphylococcus aureusMinimum inhibitory concentrationPhenotypesPulsed-field gel electrophoresisResearch laboratoriesVancomycin Issue Published: 1 February 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...