Recurrent Severe Acute Hepatitis and Omeprazole
Authors: Juan F. Navarro
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Recurrent Severe Acute Hepatitis and OmeprazoleJuan F. Navarro, MD, Eduardo Gallego, MD, and Juan Aviles, MDJuan F. Navarro, MDHospital Nuestra Senora de Candelaria; 38010 Santa Cruz de Tenerife, Spain, Eduardo Gallego, MDHospital Nuestra Senora de Candelaria; 38010 Santa Cruz de Tenerife, Spain, and Juan Aviles, MDHospital Nuestra Senora de Candelaria; 38010 Santa Cruz de Tenerife, SpainAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Omeprazole is widely used to treat acid-related disorders. The overall incidence of adverse events is low; most events, including diarrhea, flatulence, constipation, and abdominal pain, involve the gastrointestinal tract [1, 2]. Isolated reports have described other adverse effects, including fulminant hepatic failure [3]. We report a case of recurrent severe acute hepatitis induced by omeprazole.A 30-year-old man with advanced renal failure secondary to diabetic nephropathy was admitted to our hospital in September 1995 because of epigastric pain, nausea, and darkened stools. He had been taking ranitidine, calcium carbonate, furosemide, and nifedipine for the previous 4 months. ...References1. McTavish D, Buckley MM, Heel RC. Omeprazole. An up-dated review of its pharmacology and therapeutic use in acid-related disorders. Drugs. 1991; 42:138-70. Google Scholar2. Wilde MI, McTavish D. Omeprazole. An up-dated review of its pharmacology and therapeutic use in acid-related disorders. Drugs. 1994; 48:91-132. Google Scholar3. Jochem V, Kirkpatrick R, Greenson J, Brogan M, Sturgis T, CookGlenn C. Fulminant hepatic failure related to omeprazole. Am J Gastroenterol. 1992; 87:523-5. Google Scholar4. Loe WH. Drug-induced hepatotoxicity. N Engl J Med. 1995; 333:1118-27. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hospital Nuestra Senora de Candelaria; 38010 Santa Cruz de Tenerife, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmune‐mediated drug‐induced liver injury secondary to Omeprazole: A case reportDrugs and ToxinsUne hépatite aiguë grave au sévofluraneOmeprazoleHepatic injury due to drugs, herbal compounds, chemicals and toxinsAcute Hepatitis Attack After Exposure to TelithromycinHepatitis aguda colestásica por omeprazolOmeprazoleAcute upper gastrointestinal haemorrhage resulting in transient hepatic failure following liver resectionLansoprazole-Induced Hepatic DysfunctionThe Role of Cisapride in the Treatment of Pediatric Gastroesophageal RefluxAcute Hepatitis Related to OmeprazoleGastrointestinal drugsOmeprazole 15 December 1997Volume 127, Issue 12Page: 1135-1136KeywordsAbdominal painAlanine aminotransferaseDrugsHepatitisHepatitis ALiverLiver function testsResearch laboratoriesSerum glutamic oxaloacetic transaminaseUltrasound imaging Issue Published: 15 December 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...