tbuckley/cabot-search huggingface dataset:
Cure of Mediastinal Seminoma
Authors: Kishan J. Pandya, Yuang-Chi Chang
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 October 1982Cure of Mediastinal SeminomaKISHAN J. PANDYA, M.D., YUANG-CHI CHANG, M.D.KISHAN J. PANDYA, M.D.Search for more papers by this author, YUANG-CHI CHANG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-4-618_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the report of successful treatment of patients with advanced extragonadal germ-cell tumors with combination chemotherapy by Hainsworth and associates (1). We wish to report a patient with massive mediastinal seminoma apparently cured 21Z2 years after receiving only two courses of combination chemotherapy.A 26-year-old man presented with weight loss of about 4 kg, fever, shortness of breath of 2 months duration, and recent hoarseness of voice. At physical examination the patient had a temperature of 38.6 °C, bilateral small anterior cervical and axillary lymph nodes, pericardial rub, and liver edge 4 cm below...Reference1. HAINSWORTHEINHORNWILLIAMSSTEWARTCREIO JLSMA. Advanced extragonadal germ-cell tumors: successful treatment with combination chemotherapy. Ann Intern Med. 1982;97:7-11. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KISHAN J. PANDYA, M.D.; YUANG-CHI CHANG, M.D.Affiliations: St. Mary's Hospital Rochester, NY 14611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe role of radiotherapy in the treatment of primary mediastinal seminomaCorrection: Dactinomycin DoseJONATHAN D. ADAMS, PHARM, D., JAMES P. WILSON, PHARM, D. 1 October 1982Volume 97, Issue 4Page: 618-618KeywordsCombination chemotherapyDyspneaFeversLiverLymph nodesPatientsTemperatureWeight loss ePublished: 1 December 2008 Issue Published: 1 October 1982 PDF downloadLoading ...
ABC of General Paediatric Surgery: INGUINAL HERNIA, HYDROCELE, AND THE UNDESCENDED TESTIS
Authors: M. Davenport
Journal: BMJ (1996)

Clinical embryology and anatomy of the inguinal region dutomna '~The testis is formed from coelomic epithelium and primordial germ cells in a longitudinal fold high on the posterior abdominal wall at a similar level to the developing kidneys.As gestation proceeds, the testis migrates down the posterior wall towards the deep inguinal ring, probably under the control of the hormone mullerian duct inhibitory factor.The gubernaculum, a condensation of mesenchyme, forms _ within the future inguinal canal and guides the testis through the layers i_______ of the body wall towards the scrotum.Two factors seem to be important in this second stage-the release of testosterone from the fetal testis itself and an intact genitofemoral nerve, which probably -\ l <;releases substances causing gubernacular contraction.A tongue of the peritoneal cavity also precedes the migrating testis through the canal-the processus vaginalis.After birth this peritoneal communication should obliterate and disappear, but failure to do this may lead to two of the commonest problems of this region, hernias and .....%'..%-.hydroceles.Anatomy of the processus vaginalis. Inguinal herniasAnatomically these are virtually all indirect and often complete (that is, the sac comes all the way t-o the scrotum).Infantile hernias occur in about 1-2% of births and are much more common in premature babies than in full term infants.They appear as an intermittent, usually reducible, lump in the groin.The correct management is a surgical herniotomy when the child's condition allows.In most uncomplicated cases this should be within two or three weeks of diagnosis.Infant Possible reasons for an impalpable testis* Anorchia-There is no testis * Intra-abdominal testis-The testis is undescended and lies within the abdomen * Dysplastic testis-The testis is small and usually very abnormal
SIGNIFICANCE AND PREDICTORS OF PROSTHESIS–PATIENT MISMATCH IN PATIENTS UNDERGOING TAVR WITH COREVALVE AND SAPIEN XT
Authors: Konstantinos Stathogiannis, Konstantinos Toutouzas, Konstantinos Spargias, George Latsios, Andreas Synetos, Antonios Mastrokostopoulos, Stella Brili, Michalis Chrissoheris, Antonios Chalapas, Aias Antoniades, Gregory Pavlides, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2013)
Temporal trends (1975 through 1990) in the incidence and case-fatality rates of primary ventricular fibrillation complicating acute myocardial infarction. A communitywide perspective.
Authors: D Chiriboga, J Yarzebski, R J Goldberg, J M Gore, J S Alpert
Journal: Circulation (1994)

BACKGROUND As part of a population-based study of acute myocardial infarction, we examined changes over time in the incidence and in-hospital case-fatality rates of primary ventricular fibrillation complicating acute myocardial infarction. METHODS AND RESULTS Patients with validated acute myocardial infarction hospitalized at 16 hospitals in the Worcester, Mass, metropolitan area between 1975 and 1990 comprised the study sample. During the 15-year study period, 5.1% of patients developed primary ventricular fibrillation in the setting of uncomplicated acute myocardial infarction, with this rate remaining relatively constant over time. Both age- and multivariable-adjusted analyses showed no significant trend in the incidence rates of primary ventricular fibrillation during the study period. The in-hospital case-fatality rate for patients with primary ventricular fibrillation was significantly elevated compared with the rate for those without primary ventricular fibrillation and uncomplicated acute myocardial infarction (48.3% versus 1.5%, P &lt; .001). No significant change over time was noted in in-hospital case-fatality rates associated with primary ventricular fibrillation while controlling for a variety of short-term prognostic factors. CONCLUSIONS The results of this communitywide observational study suggest that neither the incidence nor the prognosis associated with primary ventricular fibrillation resulting from acute myocardial infarction has improved over time.
Australia Antigen and Malignant Hepatoma
Authors: G. THEODOROPOULOS
Journal: Annals of Internal Medicine (1975)

LettersJune 1, 1975Australia Antigen and Malignant HepatomaG. THEODOROPOULOS, M.D., A. ARCHIMANDRITIS, M.D., B. ANGELOPOULOS, M.D.G. THEODOROPOULOS, M.D.Search for more papers by this author, A. ARCHIMANDRITIS, M.D.Search for more papers by this author, B. ANGELOPOULOS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-809 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1970 Sherlock and co-workers (1) were the first to describe five cases of malignant hepatoma associated with a positive Au(1) serologic test. Some months later, there was a report of a high prevalence of Au(1) in the serum of Ugandan patients with hepatocellular carcinoma. These findings "provided suggestive evidence that virus hepatitis B at least is a precancerous condition" (2). However, the results of other investigations carried out in different areas of the world to establish this association are controversial. A high prevalence of Au(1) has been observed in patients suffering from hepatoma in Senegal, Uganda, India, Spain, Chile,...References1. SHERLOCKFOXNIAZI SRS: Chronic liver disease and primary liver-cell cancer with hepatitis-associated (Australia) antigen in serum. Lancet 1:1243-1247, 1970 CrossrefMedlineGoogle Scholar2. SHERLOCK S: Diseases of the liver and biliary system, 4th ed. Oxford and Edinburgh, Blackwell Scientific Publications, 1971, p. 338 Google Scholar3. PRINCEBROTMANJASS ABD: Specificity of the direct solid-phase radioimmunoassay for detection of hepatitis B antigen. Lancet 1:1346-1350, 1973 CrossrefMedlineGoogle Scholar4. ALPERTHERSHBERGSCHUR ERP: α-Fetoprotein in human hepatoma: improved detection in serum and quantitative studies using a new sensitive technique. Gastroenterology 61:137-143, 1971 CrossrefMedlineGoogle Scholar5. SUTNICK A: Australia antigen: progress report. Med Clin North Am 57:1029-1043, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Pathologic Physiology Medical School University of Athens Athens 609 Greece PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 1, 1975Volume 82, Issue 6Page: 809-810KeywordsAntigens Issue Published: June 1, 1975 PDF downloadLoading ...
Epidemic Expenses?-Reply
Authors: Bernard S. Bloom
Journal: JAMA (1985)

In Reply.—  Dr Lau is correct in his use of the traditional definition of epidemiology. However, we felt it quite appropriate to expand the definition to include those  states and events in populations as used by Last 1 in our study of the economic effects of children's cancer. 2 We were examining the effects of this disease over time in a defined population using epidemiologic techniques. One needs to study not only the distribution of disease and determinants of health, but also those related events bearing on disease and health, to still feel comfortable in referring to it as an epidemiologic investigation.
TCT-815 Positive Vascular Remodeling and Plaque Vulnerability: Biological Insights from the Novel Familial Hypercholesterolemic Swine Model of Atherosclerosis
Authors: Masahiko Shibuya, Armando Tellez, Yanping Cheng, Carlos A. Gongora, Athanasios Peppas, Matthew Purdy, Samantha G. Stone, William Rate, Christian Krueger, Dhanansayan Shanmuganayagam, Greg L. Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2013)
Abstract 4148: Rapamycin potentiates the effects of paclitaxel in uterine papillary serous carcinoma (UPSC) cells through inhibition of cell proliferation and induction of apoptosis
Authors: Albert Mendivil, Chunxiao Zhou, Leigh Cantrell, Paola Gehrig, Kim Malloy, Victoria L. Bae-Jump
Journal: Cancer Research (2010)

Abstract Objectives: Treatment of women with uterine papillary serous carcinoma (UPSC) using cytotoxic chemotherapeutic agents has been met with limited success. This has led to the search for an additional agent that could be used in combination with more traditional therapies to dramatically increase therapeutic efficacy while not increasing toxicities. Among the most promising of these for endometrial cancer are inhibitors of the mammalian target of rapamycin (mTOR). Rapamycin and paclitaxel have been found to be synergistic in type I endometrial cancer cell lines. Thus, our objective was to examine the effects of combined therapy with rapamycin and paclitaxel in a UPSC cell line. Methods: The UPSC cell line, SPEC-2 was used. Cell proliferation was assessed after exposure to rapamycin or paclitaxel alone or in combination, and viable cell densities were determined by measuring conversion of the metabolic dye, MTT. Apoptosis was assessed by flow cytometric analysis of annexin-V expression. hTERT expression, as a marker of telomerase activity, was determined by real-time RT-PCR. Western immunoblotting was performed to determine the expression of the downstream targets of the mTOR pathway, including phosphorylated S6 and 4E-BP-1. Results: Paclitaxel inhibited proliferation in a dose-dependent manner in the SPEC-2 cell line, with an IC50 value of 1-10 nM. Simultaneous exposure of cells to various doses of paclitaxel in combination with rapamycin (1 nM) resulted in a significant synergistic anti-proliferative effect (p=0.0032-0.0059). In addition, rapamycin increased paclitaxel-induced apoptosis over that of paclitaxel alone. Rapamycin decreased hTERT mRNA expression while paclitaxel alone had no effect on telomerase activity. Rapamycin decreased phosphorylation of the S6 and 4E-BP-1 proteins after 24 hrs of exposure. In contrast, paclitaxel had little effect on 4E-BP-1 phosphorylation but did induce phosphorylation of S6 at higher doses (10 nM). Treatment with paclitaxel and rapamycin resulted in overall decreased phosphorylation of both S6 and 4E-BP-1. Conclusions: We demonstrate that rapamycin potentiates the effects of paclitaxel in UPSC cells through inhibition of cell proliferation and induction of apoptosis. This suggests that the combination of rapamycin and paclitaxel may be a promising effective targeted therapy for UPSC, an aggressive and often lethal subtype of endometrial cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4148.
535 MODERATE TO SEVERE CHRONIC RENAL DYSFUNCTION INFLUENCES LONG-TERM SURVIVAL AFTER LIVER TRANSPLANTATION (LT)
Authors: S. Faure, Y. Duny, G. Thoni, B. Vicendo, A. Herrero, B. Yung, F. Navarro, S. Jaber, D. Larrey, G.P. Pageaux
Journal: Journal of Hepatology (2011)
Pleural effusions associated with pancreaticopleural fistula.
Authors: S G Williams, A Bhupalan, N Zureikat, P J Thuluvath, G Santis, N Theodorou, D Westaby
Journal: Thorax (1993)

Two cases of pancreaticopleural fistula are reported. The delay in diagnosis and extensive investigations performed highlight the need for pleural fluid amylase estimation at an early stage.
How to Read a Paper: The Basics of Evidence-Based Medicine
Authors: David Warriner
Journal: BMJ (2008)

Now in its third edition, this respected book guides the reader through medical research and the jungle of jargon it comprises. The subject matter is divided into types of research, literature searches, presenting and analysing data, and publication and appraisal of research. Its definitions are superb, and it clearly delineates between commonly confused topics such as reliability and validity, systematic reviews and meta-analyses, and protocol and guidelines.

In the 12 years since the book’s inception evidence based medicine has evolved from illegitimacy to prodigy, thanks to champions such as David Sackett, Brian Haines, and Greenhalgh herself. They encourage clinicians to formulate the right question with three specific …
TCT-857 Three Dimensional Multi-detector Computed Tomography Predictors Of Prosthesis-Patient Mismatch In Transcatheter Aortic Valve Replacement
Authors: Melanie Freeman, John Webb, Alexander Willson, Miriam Wheeler, Robert Moss, Chris Thompson, Brad Munt, Bjarne Nørgaard, James Min, Steen Poulsen, Ronald Binder, Stefan Toggweiler, Cameron Hague, David Wood, Jonathon Leipsic
Journal: Journal of the American College of Cardiology (2012)
Epidemic spread of Salmonella hadar in England and Wales.
Authors: B Rowe, M L Hall, L R Ward, J D de Sa
Journal: BMJ (1980)

Salmonella hadar is now the second commonest serotype isolated from cases of food poisoning in England and Wales. Turkeys are the main reservoir of the organism and there is an urgent need to eradicate it from the breeding stocks; though this would be expensive, the cost must be balanced against the cost of treating the human disease.
Pulse Methylprednisolone Therapy in Idiopathic, Rapidly Progressive Glomerulonephritis
Authors: OLU OREDUGBA
Journal: Annals of Internal Medicine (1980)

Idiopathic crescentic glomerulonephritis is associated with a 70% to 80% incidence of end-stage renal failure. Oral corticosteroid therapy in combination with immunosuppressive agents or anticoagulants has not altered the prognosis of this disease. We have seen five adults with idiopathic crescentic glomerulonephritis and treated them with intravenous methylprednisolone. Before therapy, the average serum creatinine concentration was 7.4 ± 1.3 mg/dL (chi-square ± SEM). This value declined to 2.0 ± 0.48 mg/dL within 4 weeks. All patients continue to maintain stable renal function over an average follow-up period of 19 months (range, 1.5 to 36 months). These data suggest that a prospective controlled trial of this therapy is warranted in the management of this entity.
Bedside Prediction of Clostridium difficile Colitis
Authors: David E. Langdon
Journal: Annals of Internal Medicine (1997)

Letters15 June 1997Bedside Prediction of Clostridium difficile ColitisDavid E. Langdon, MDDavid E. Langdon, MDArlington, TX 76015Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-12-199706150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The John Hopkins group's paper on diagnosing Clostridium difficile colitis [1], several letters to the editor and the Hopkins researchers' reply [2], and Dr. Surawicz's commentary in another journal [3] all discuss clinical associations, laboratory diagnostics, and options. Surprisingly, none mentions that diagnosing this condition is one of the few remaining roles for the highly portable old proctoscope! In these sick patients, if laboratory results are delayed or negative, then, with super suction ready and using left lateral decubitus position (the patient usually in the hospital room and in bed) one can, within a few comfortable inches, ...References1. Manabe YC, Vinetz JM, Moore RD, Merz C, Charache P, Bartlett JG. Clostridium difficile colitis: an efficient clinical approach to diagnosis. Ann Intern Med. 1995; 123:835-40. Google Scholar2. Vinetz JM, Manabe Y, Bartlett JG. Diagnosis of Clostridium difficile colitis [Letter]. Ann Intern Med. 1996; 125:516. Google Scholar3. Surawicz CM. World literature review. Am J Gastroenterol. 1996; 91:1662-3. Google Scholar Author, Article, and Disclosure InformationAuthors: David E. Langdon, MDAffiliations: Arlington, TX 76015 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1997Volume 126, Issue 12Page: 1004KeywordsC difficile colitisClinical laboratoriesColitisDiagnostic techniquesEndoscopyRectumResearch laboratories ePublished: 15 August 2000 Issue Published: 15 June 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Edoxaban was noninferior to warfarin for preventing recurrent venous thromboembolism, with less bleeding
Authors: Stephan Thomé
Journal: Annals of Internal Medicine (2014)

ACP Journal Club21 January 2014Edoxaban was noninferior to warfarin for preventing recurrent venous thromboembolism, with less bleedingStephan Thomé, MDStephan Thomé, MDMayo Clinic College of Medicine, Rochester, Minnesota, USA (S.T.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-160-2-201401210-02004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationHokusai-VTE Investigators. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med. 2013;369:1406-15. https://pubmed.ncbi.nlm.nih.gov/23991658Clinical Impact RatingsGIM/FP/GP: Cardiology: Hematology: References1 Eikelboom JW, Connolly SJ, Brueckmann M, et al; RE-ALIGN Investigators. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med. 2013;369:1206-14. [PMID: 23991661] Google Scholar2 EINSTEIN Investigators, Bauersachs R, Berkowitz SD, et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Eng J Med. 2010;363;2499-510. [PMID: 21128814] Google Scholar3 Agnelli G, Buller HR, Cohen A; AMPLIFY Investigators. Oral apixaban for the treatment of acute venous thromboembolism. N Eng J Med. 2013;369;799-808. [PMID: 23808982] Google Scholar Author, Article, and Disclosure InformationAuthors: Stephan Thomé, MDAffiliations: Mayo Clinic College of Medicine, Rochester, Minnesota, USA (S.T.)This article was published at Annals.org on 7 January 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIdentification of potential drug targets based on a computational biology algorithm for venous thromboembolism 21 January 2014Volume 160, Issue 2 Page: JC4 Keywords Cancer treatment Creatinine Deep vein thrombosis Hazard ratio Hemorrhage Heparin Pulmonary embolism Safety Venous thromboembolism Vitamin K ePublished: 21 January 2014 Issue Published: 21 January 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Rheumatoid Arthritis in a Patient with Hageman Trait
Authors: Virginia H. Donaldson, Helen I. Glueck, Timothy Fleming
Journal: New England Journal of Medicine (1972)

UPON activation, the Hageman factor in plasma initiates blood coagulation as well as events that lead to the release of biologically active polypeptides, called kinins. Kinins produce signs of inflammation by inducing vasodilatation, increased vascular permeability and pain.1 2 3 4 5 6 The case to be described raises an important exception to the proposal that activation of Hageman factor may be required for the formation of kinins in synovial fluids and symptoms of rheumatoid arthritis,7 8 9 10 11 for rheumatoid arthritis developed in a woman with a severe deficiency of Hageman factor.Case ReportA 43-year-old married woman was seen in January, 1967, because of acutely red, . . .
Correction: Disputed Pakistan-India Territory
Authors: None Afrasiab
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 October 1988Correction: Disputed Pakistan-India TerritoryAfrasiabAfrasiabSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-7-600_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In the article by Simon and Hyman (1), the map of the geography and political boundaries of Afghanistan is incorrect. On the map, the area of Jammu and Kashmir, which is a disputed territory, has been shown as part of India. According to a resolution of the United Nations, the final status of this area is yet to be decided. Moreover, all of the publications of the United Nations and the major publishers of these maps have indicated the disputed nature of Kashmir by inserting explanatory notes in their maps. Thus, the disputed area should have been...Reference1. SimonHyman RM. Establishing underground medical clinics in rural Afghanistan: the international medical corps experience. Ann Intern Med. 1988;108:477-80. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1988Volume 109, Issue 7Page: 600-600 ePublished: 1 December 2008 Issue Published: 1 October 1988 PDF downloadLoading ...