tbuckley/cabot-search huggingface dataset:
Long-Term Evolution and Prognostic Stratification of Biopsy-Proven Active Myocarditis
Authors: Marco Anzini, Marco Merlo, Gastone Sabbadini, Giulia Barbati, Gherardo Finocchiaro, Bruno Pinamonti, Alessandro Salvi, Andrea Perkan, Andrea Di Lenarda, Rossana Bussani, Jozef Bartunek, Gianfranco Sinagra
Journal: Circulation (2013)

Active myocarditis is characterized by large heterogeneity of clinical presentation and evolution. This study describes the characteristics and the long-term evolution of a large sample of patients with biopsy-proven active myocarditis, looking for accessible and valid early predictors of long-term prognosis.From 1981 to 2009, 82 patients with biopsy-proven active myocarditis were consecutively enrolled and followed-up for 147±107 months. All patients underwent clinical and echocardiographic evaluation at baseline and at 6 months. At this time, improvement/normality of left ventricular ejection fraction (LVEF), defined as a LVEF increase > 20 percentage points or presence of LVEF≥50%, was assessed. At baseline, left ventricular dysfunction (LVEF<50%) and left atrium enlargement were independently associated with long-term heart transplantation-free survival, regardless of the clinical pattern of disease onset. At 6 months, improvement/normality of LVEF was observed in 53% of patients. Persistence of New York Heart Association III to IV classes, left atrium enlargement, and improvement/normality of LVEF at 6 months emerged as independent predictors of long-term outcome. Notably, the short-term reevaluation showed a significant incremental prognostic value in comparison with the baseline evaluation (baseline model versus 6 months model: area under the curve 0.79 versus 0.90, P=0.03).Baseline left ventricular function is a marker for prognosis regardless of the clinical pattern of disease onset, and its reassessment at 6 months appears useful for assessing longer-term outcome.
Communicating the Results of Randomized Clinical Trials: Do Patients Understand Multidimensional Patient-Reported Outcomes?
Authors: Angus G.K. McNair, Sara T. Brookes, Christopher R. Davis, Miltiadis Argyropoulos, Jane M. Blazeby
Journal: Journal of Clinical Oncology (2010)

Purpose Evidence suggests that patient-reported outcomes (PROs) from randomized trials in oncology may not influence clinical decision making and patient choice. Reasons for this are currently unclear and little is known about patients' interpretation of PROs. This study assessed patients' understanding of multidimensional PROs in a graphical format. Patients and Methods Semistructured interviews in which patients interpreted a series of graphs depicting simple, then multiple different hypothetical PROs associated with two treatments with identical chances of survival were audio recorded. The interviewer and a blinded observer (listening to audio recordings) scored patients' understanding of the graphs. Logistic regression examined the associations between patient understanding of the graphs and clinical and sociodemographic details. Results One hundred thirty-two patients with esophageal and gastric cancer were interviewed and 115 understood the first two graphs depicting different PROs of two treatments (87%; 95% CI,81 to 93). Simultaneous interpretation of adverse and beneficial treatment effects was achieved by 74 (66%; 95% CI, 57 to 75). Graphs showing complex, longitudinal data were correctly interpreted by 97 (73%; 95% CI, 66 to 81) and 108 (81%; 95% CI, 75 to 88), respectively. Univariable analyses demonstrated associations between patient understanding and patient age, educational level, and cancer site (P ≤ .02 for all); however, in a multivariable model each of these associations was attenuated. Conclusion Most patients understand graphical multidimensional PROs, although a smaller majority were able to interpret more complex, or simultaneous, presentations. Additional work is needed to define methods for communicating clinical and PRO data from trials to allow patients to make informed treatment choices.
Abstract LB-263: Synthetic lethal targeting of PTEN-associated homologous recombination (HR) deficient melanoma cells by human apurinic/apyrimidinic endonuclease (APE1) inhibitors
Authors: Rachel M. Abbotts, Rebeka Sultana, Claire Seedhouse, Poulam M. Patel, David M. Wilson, Srinivasan Madhusudan
Journal: Cancer Research (2012)

Abstract Background Mutation of the tumour suppressor PTEN is well-characterised in many advanced malignancies, including 30-50% of metastatic melanomas. Emerging evidence suggests a new role for PTEN in DNA repair, through transcriptional downregulation of the critical HR protein RAD51. Tumour cells deficient in HR (such as BRCA-deficient breast and ovarian cancers) have been therapeutically targeted in a synthetic lethality (SL) strategy using PARP inhibitors that block single strand break repair (SSBR), a pathway related to base excision repair (BER). We have previously identified novel inhibitors of the critical BER enzyme APE1, and demonstrated these can induce SL in BRCA-deficient cell lines. In the current study, we have evaluated SL relationships in PTEN-proficient and -deficient melanoma systems for a potential novel treatment strategy. Method We screened a panel of melanoma cell lines (MeWo, MM418, SkMel28, SkMel30, HT144, UACC62) for PTEN, APE1 and RAD51 protein expression. We tested for SL using clonogenic survival assays in PTEN- and RAD51-deficient cell lines using our recently developed APE1 DNA repair domain inhibitors, methoxyamine (indirect APE1 inhibitor) and NU1025 (PARP inhibitor), either alone or in combination. Aldehyde reactive probe assay, neutral comet assay, γH2AX immunofluorescence and FACS analyses were performed to confirm biological activity in cells. Results Of the screened cell lines, SkMel28, HT144 and UACC62 were deficient in PTEN and RAD51 protein expression. APE1 inhibitors were more toxic to PTEN-deficient cells compared to PTEN-proficient cells (p&amp;lt;0.01). Significant sensitivity was also seen in PTEN-deficient cells treated with methoxyamine (p&amp;lt;0.05) and PARP inhibitors (p&amp;lt;0.001), confirming that BER modulation results in SL in PTEN deficiency. This increased cytotoxicity in PTEN deficiency is associated with accumulation of DNA double strand breaks (DSB), as assessed by comet assay (p&amp;lt;0.001) and γH2AX accumulation (p&amp;lt;0.05). DSB accumulation leads to G2/M arrest and apoptosis, as demonstrated by FACS analysis. Conclusion Our data provides the first pre-clinical evidence that targeting APE1 in PTEN-RAD51 deficient melanoma cells is a promising new SL strategy. We are complementing the current small molecule studies by developing PTEN knockout systems using shRNA technology. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-263. doi:1538-7445.AM2012-LB-263
Testing patients to allow tailored drug treatment
Authors: Peter Leman, Shaun Greene
Journal: BMJ (2005)

The application of pharmacogenetics in preventing adverse drug reactions as illustrated by Konstantopoulou et al1 is not new. In 510 bc Pythagoras observed that only some individuals—those with a deficiency of glucose-6-phosphate dehydrogenase (G6PD)—developed a potentially fatal reaction after ingesting fava beans. For nearly 50 years anaesthetists have been identifying patients who may have a deficiency of normal plasma cholinesterase (leading to prolonged suxamethonium neuromuscular blockade or “scoline apnoea”) by taking a simple patient history.2

Although the development of modern pharmacogenetic assays designed to reduce the incidence of adverse drug reactions is still its infancy, the case presented by Konstantopoulou et al …
Subacute Thrombosis and Vascular Injury Resulting From Slotted-Tube Nitinol and Stainless Steel Stents in a Rabbit Carotid Artery Model
Authors: Sushil Sheth, Frank Litvack, Vishva Dev, Michael C. Fishbein, James S. Forrester, Neal Eigler
Journal: Circulation (1996)

Background Our objectives were to quantify the thrombogenicity and extent of vascular injury created by slotted-tube geometry stainless steel and nitinol coronary stents in a rabbit carotid artery model. Methods and Results Stents were implanted in rabbit right carotid arteries without antiplatelet therapy. Stainless steel stents were implanted for 4 days while nitinol stents were placed for 4 and 14 days (n=8, 8, and 6, respectively). Stent thrombosis was assessed by thrombus weight, grading thrombus encroachment of the lumen, and by blood flow in the stented and contralateral arteries. Stainless steel stents at 4 days contained more thrombus than 4- and 14-day nitinol stents (20.0±5.9 versus 2.5±0.6 and 2.7±0.3 mg, respectively; P &lt;.000001). Stainless steel stents were more often occluded by thrombus (6 of 8) or contained more subocclusive thrombus (2 of 8) than nitinol stents (0 of 14, P &lt;.002). Resting blood flow was reduced in arteries with stainless steel stents compared with 4- and 14-day nitinol stents (1.5±2.8 versus 24.0±2.0 and 25.5±1.9 mL/min, respectively, P &lt;.000001). Stainless steel stents were less uniformly expanded, had deeper strut penetration into the vascular wall, and were associated with more extensive medial smooth muscle cell necrosis. There were strong correlations ( r =.77 to .95) between variables of thrombosis extent (thrombus weight and grade) and histologically determined vascular injury (strut penetration and medial necrosis). Conclusions Slotted-tube stainless steel stents were more thrombogenic and created more extensive vascular injury than nitinol stents in a rabbit carotid artery model. The mechanisms underlying these differences probably are related to metallurgic and design geometry properties of the two stent types.
Approaches to Regional Nodes in Patients With Melanoma
Authors: Danielle K. DePeralta, Mai P. Hoang, Kenneth K. Tanabe
Journal: Journal of Clinical Oncology (2014)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2013.52.3571 Journal of Clinical Oncology - published online before print February 10, 2014 PMID: 24516017 Approaches to Regional Nodes in Patients With Melanoma Danielle K. DePeraltaxDanielle K. DePeraltaSearch for articles by this author Mai P. HoangxMai P. HoangSearch for articles by this author Kenneth K. TanabexKenneth K. TanabeSearch for articles by this author Show More Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MAMassachusetts General Hospital and Harvard Medical School, Boston, MAMassachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA https://doi.org/10.1200/JCO.2013.52.3571 First Page Full Text PDF Figures and Tables © 2014 by American Society of Clinical Oncology
The Interferon Regulatory Transcription Factor IRF-1 Controls Positive and Negative Selection of CD8+ Thymocytes
Authors: Josef M Penninger, Christian Sirard, Hans-Willi Mittrücker, Anne Chidgey, Ivona Kozieradzki, Mai Nghiem, Anne Hakem, Tohru Kimura, Emma Timms, Richard Boyd, Tadatsugu Taniguchi, Toshifumi Matsuyama, Tak W Mak
Journal: Immunity (1997)
Effect of pulsed electromagnetic fields on proteoglycan biosynthesis of articular cartilage is age dependent
Authors: K Bobacz
Journal: Annals of the Rheumatic Diseases (2005)

To investigate the effects of a pulsed electromagnetic field (EMF) on articular cartilage matrix biosynthesis with regard to age and cartilage damage using a matrix depleted cartilage explant model.Cartilage explants were obtained from metacarpophalangeal joints of calves and adult cows. After depletion of the extracellular matrix by trypsin digestion, samples were maintained in serum-free basal medium with and without the addition of interleukin 1beta (IL1beta). Half the samples were subjected to an EMF for 24 minutes daily; the other half were left untreated. Undigested and untreated explants served as negative controls. After 7 days, biosynthesis of matrix macromolecules was assessed by [35S]sulphate incorporation and values were normalised to hydroxyproline content.The EMF increased matrix macromolecule synthesis in undigested, untreated explants (p<0.009). In matrix depleted samples the EMF had no stimulatory effect on proteoglycan biosynthesis. IL1beta significantly decreased the de novo synthesis of matrix macromolecules (p<0.00004) in young and adult samples, but an EMF partly counteracted this inhibitory effect in cartilage samples from young, but not old animals.EMF promoted matrix macromolecule biosynthesis in intact tissue explants but had no stimulatory effect on damaged articular cartilage. The supressive effects of IL1beta were partially counteracted by EMF exposure, exclusively in cartilage derived from young animals. An EMF has age dependent chondroprotective but not structure modifying properties when cartilage integrity is compromised.
Hyperthermia Research Rekindled After Poor U.S. Start
Authors: L. Seachrist
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Hyperthermia Research Rekindled After Poor U.S. Start Get access Lisa Seachrist Lisa Seachrist Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 21, 3 November 1993, Pages 1713–1715, https://doi.org/10.1093/jnci/85.21.1713 Published: 03 November 1993
A CASE OF LYMPHADENOMA WITH CUTANEOUS LESIONS.‡
Authors: DUDLEY CORBETT
Journal: British Journal of Dermatology (1917)

Journal Article A CASE OF LYMPHADENOMA WITH CUTANEOUS LESIONS. Get access DUDLEY CORBETT, M.D. DUDLEY CORBETT, M.D. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 29, Issue 1, 1 January 1917, Pages 46–58, https://doi.org/10.1111/j.1365-2133.1917.tb09651.x Published: 01 January 1917
DOES OBESITY AFFECT RESPONSE TO TREATMENT IN ACUTE DECOMPENSATED HEART FAILURE? A DIURETIC OPTIMIZATION STRATEGIES EVALUATION (DOSE) TRIAL SUBSTUDY
Authors: Achal Gupta, Josef Stehlik, Steven McNulty, Kerry L. Lee, Edward M. Gilbert, Deborah Budge, Kevin Anstrom, David A. Bull, G. Michael Felker, Divya R. Verma, Stavros G. Drakos, Theophilus Owan, Christopher M. O'Connor, Sheldon E. Litwin
Journal: Journal of the American College of Cardiology (2011)
Heterogeneous impact of the non-contributory pension programme 70 y más on nutritional status of the elderly in rural Mexico
Authors: Martha M Téllez-Rojo, Betty Manrique-Espinoza, Karla Moreno-Tamayo, Vanessa De la Cruz-Góngora, Gustavo Ángeles, Aarón Salinas-Rodríguez
Journal: The Lancet (2013)
Effect of divalent cations and pH on intrinsic factor-mediated attachment of vitamin B12 to intestinal microvillous membranes
Authors: Iain L. Mackenzie, Robert M. Donaldson
Journal: Journal of Clinical Investigation (1972)

Calcium, but not other divalent cations, is required for optimal uptake of intrinsic factor-bound (57)Co-labeled cyanocobalamin (IFB(12)) by microvillous membranes isolated from hamster ileal-absorptive cells. Chelation of divalent cations by disodium ethylenediaminetetraacetate (EDTA) promptly removes IFB(12) previously attached to microvillous membranes. High concentrations of CaCl(2) or MgCl(2) also markedly inhibit membrane uptake of IFB(12) and rapidly remove previously attached IFB(12). Similarly, reduction of pH to below 5.4 prevents membrane attachment of IFB(12) and removes virtually all IFB(12) already bound to microvillous membranes. The effects of calcium depletion, increased salt concentrations, and acidification on membrane uptake of IFB(12) were completely reversible. These findings are consistent with the concept that the formation of calcium salt bridges is essential for attachment of IFB(12) to the ileal-absorptive surface.
At 10 years, 55% of patients with Parkinson disease died; 23% had a good outcome
Authors: Joseph H. Friedman
Journal: Annals of Internal Medicine (2013)

Source Citation Williams-Gray CH, Mason SL, Evans JR, et al. The CamPaIGN study of Parkinsons disease: 10-year outlook in an incident population-based cohort. J Neurol Neurosurg Psychiatry. 2013;84:1258-1264. 23781007
Surgical Emergencies in the Newborn
Authors: John G. Raffensperger
Journal: JAMA (1972)

A surgical emergency in the newborn infant is the real reason for the existence of pediatric surgeons. Congenital anomalies incompatible with life require prompt diagnosis and correction by a surgeon who is experienced with the unique physiologic responses of the newborn infant. Drs. Haller and Talbert have focused on the early diagnosis and therapy of anomalies of the respiratory, cardiovascular, and gastrointestinal tract, as well as on neonatal trauma. Perhaps the most valuable portions of the book deal with preoperative and postoperative care. The authors have had considerable experience in monitoring the ill postoperative newborn infant, and perhaps they place too much stress on invasive monitoring techniques. Each venipuncture for blood sampling and each catheter placement for monitoring venous and arterial pressure is a potential entry site for sepsis. Thoughtful observation with a few simple measurements are sufficient to guide most babies through major surgery. The authors did not lay
Message and medium: Lowly and action-related origins
Authors: Peter F. MacNeilage, Barbara L. Davis
Journal: Behavioral and Brain Sciences (2003)

Hurford presents a much-needed lowly origins scenario for the evolution of conceptual precursors to lexical items. But more is still needed on action, regarding both the message level of lexical concepts and the medium. We summarize our complementary action-based lowly origins (frame/content) scenario for the vocal auditory medium of language, which, like Hurford's scenario, is anchored in a phylogenetically old neurological dichotomy.
Socioeconomic status and antisocial behaviour among children and adolescents: A systematic review and meta-analysis
Authors: Patrycja J. Piotrowska, Christopher B. Stride, Simone E. Croft, Richard Rowe
Journal: Clinical Psychology Review (2014)

Previous research on the association between socioeconomic status (SES) and child and adolescent antisocial behaviour has produced mixed findings showing variation in the strength of association. This systematic review and meta-analysis aimed to summarise evidence on the relationship between socioeconomic status and broadly conceptualised antisocial behaviour, investigating variation across a range of antisocial subtypes and other potential moderators, including age, sex and informant. We identified 133 studies containing data suitable for effect size calculation, and 139 independent effect sizes were analysed (total N=339868). The global meta-analysis showed that lower family socioeconomic status was associated with higher levels of antisocial behaviour. Moderation analyses revealed this relationship was stronger where callous-unemotional traits were the outcome, and where antisocial behaviour was reported by parents or teachers rather than self-reported. The relationship between family SES and antisocial behaviour, however, was independent of higher-level constructs such as national income inequality. These results indicate that SES can be considered a robust correlate of broadly conceptualised antisocial behaviour but the strength of this relationship may depend on the antisocial subtype under investigation and the design of the study.
JAMA 100 Years Ago
Authors: G. S. Franklin
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contractile Reserve of Dysfunctional Myocardium After Revascularization: A Dobutamine Stress Echocardiography Study
Authors: Antonella Lombardo, Francesco Loperfido, Carlo Trani, Faustino Pennestrí, Elisabetta Rossi, Alessandro Giordano, Gianfederico Possati, Attilio Maseri
Journal: Journal of the American College of Cardiology (1997)
Heat stress limits infarct size in the isolated perfused rabbit heart
Authors: D M Walker, E Pasini, S Kucukoglu, M S Marber, E Iliodromitis, R Ferrari, D M Yellon
Journal: Cardiovascular Research (1993)

Objective: Heat stress, with the expression of heat stress proteins, has been shown to protect the rabbit heart in vitro against global ischaemia/reperfusion injury, though no benefit is apparent in an in vivo rabbit model of infarct size. The aim of this study was therefore to investigate this discrepancy and to discover whether heating itself has any effect which could negate the protection derived from myocardial stress protein synthesis. Methods: (1) To ascertain whether heat stress could limit infarct size in the absence of blood, isolated buffer perfused hearts, with or without prior heat stress, were subjected to 45 min of regional ischaemia and 120 min reperfusion, and the resulting infarct size was expressed as a percentage of the risk area (I/R%). (2) The observations were repeated in an isolated blood perfused heart model in which a support rabbit (heat stressed or control) was used to perfuse the isolated heart. Results: In the buffer perfused heart, prior heat stress reduced I/R from 70.8(SEM 4.4)%, n=10, in controls to 51.5(5.7)%, n=12 (p<0.05). In hearts perfused by support rabbits, prior heat stress reduced I/R [from 34.7(3.7)%, n=16, to 23.5(3.3)%, n=15 (p<0.05)] only when the perfusing rabbit was a control (not heat stressed). If the perfusing rabbit had been heated, I/R was greater in both heat stressed and control hearts [51.9(7.0)% and 44.9(3.3)%, p<0.05 v control support rabbit]. Conclusions: Heat stress limits infarct size in this rabbit model. However it appears to have additional adverse effects, probably on the blood, which may override any benefit associated with myocardial stress protein synthesis. Cardiovascular Research 1993;27:962-967