tbuckley/cabot-search huggingface dataset:
Breast Health and Common Breast Problems: A Practical Approach
Authors: Marilyn Terranella
Journal: Annals of Internal Medicine (2004)

Medical Writings: Book Notes20 July 2004Breast Health and Common Breast Problems: A Practical ApproachMarilyn Terranella, MDMarilyn Terranella, MDFrom Kalamazoo Center for Medical Studies, Michigan State University, Kalamazoo, Michigan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-2-200407200-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Ganschow PS, Norlack FE, Jacobs EA, Marcus EA, eds. 304 pages. Philadelphia: American Coll of Physicians; 2004. $32.00. ISBN 1930513224. Order phone 800-523-1546.Field of medicine: Women's health.Format: Softcover book.Audience: Primary care physicians, nurse practitioners, and other clinicians involved in the care of women.Purpose: To provide a comprehensive, practical, and systematic approach to “frequently encountered questions about breast health, cancer risk, and the prevention, evaluation, and management of common breast disorders.”Content: This text is well organized into 5 categories of breast concerns. The opening sections of the book discuss normal breast anatomy, development, and function. The ... Author, Article, and Disclosure InformationAffiliations: From Kalamazoo Center for Medical Studies, Michigan State University, Kalamazoo, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 July 2004Volume 141, Issue 2Page: 164KeywordsBreast cancerCancer preventionHealth information technologyNursesObstetrics and gynecologyPrimary care physiciansRisk assessmentsSigns and symptomsSoftware toolsTestosterone ePublished: 20 July 2004 Issue Published: 20 July 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Oral 3,CHILD syndrome with unusual cutaneous features
Authors: C. Feighery, S. McKee, D.K.B. Armstrong
Journal: British Journal of Dermatology (2007)

We report a case of a rare epidermal naevus genetic disorder which presented with unusual cutaneous features which to our knowledge have not previously been described. A 5-year-old girl of Indian origin was noted at birth to have a shortened left leg, left arm and left index finger. A rash was first noted at 3 months of age with a red scaling eruption in the left groin and medial thigh which resolved over a few weeks leaving a residual area of macular hyperpigmentation on the thigh area. The groin eruption has since recurred. A rash with a similar morphology appeared at the age of 6 months affecting the perianal area (predominantly left sided) and this rash has persisted. The fingernails of her left hand were noted to be dystrophic at the age of 18 months as were several toenails (bilateral but not universal). In addition, she has developed hyperkeratotic areas on both soles and at the left popliteal fossa. Several of these areas have a linear morphology. There is no history of consanguinity or any family history of similar skin problems. Genetic analysis revealed a mutation in the NSDHL gene, which is responsible for CHILD syndrome. Her mother did not exhibit this mutation.
The significance of human jagged 1 mutations detected in severe cases of extrahepatic biliary atresia
Authors: Takao Kohsaka, Zeng-rong Yuan, Shu-xia Guo, Manabu Tagawa, Akio Nakamura, Miwako Nakano, Hideo Kawasasaki, Yukihiro Inomata, Koichi Tanaka, Jun Miyauchi
Journal: Hepatology (2002)

Mutations of human jagged 1 (JAG1) gene are responsible for Alagille Syndrome (AGS), whose 2 main symptoms are intrahepatic bile duct hypoplasia and pulmonary stenosis. We examined the JAG1 mutation in extrahepatic biliary atresia (EHBA), which is similar in phenotype to AGS, although a different pathogenesis is suggested. In 102 cases of EHBA, 9 missense mutations were detected, including 2 intrafamilial expressions in the propositus and an aunt of one family. These mutations were all missense and sporadic except for those of this particular family. The JAG1 gene mutations were generally found in severely ill patients subjected to liver transplantation at less than 5 years of age. None of the 9 cases of EHBA revealed any of the 5 major symptoms of AGS nor any identical pathological findings after 3 years of follow-up. Our cases were clearly separated from AGS by pathological findings and clinical features, and could be diagnosed as EHBA and not as atypical AGS. The increase of interleukin 8 (IL-8) production induced by tumor necrosis factor α (TNF-α) in Huh 7 cells was suppressed by the coexistence of JAG1 protein. We examined the different influences between wild-type cells and the 3 kinds of mutants detected in EHBA on Huh 7 cells and found that 2 of 3 mutants showed about half of the repressed activity compared with that of wild type. In conclusion, these results suggest that the JAG1 gene abnormality may be an aggravating factor in EHBA.
Mitochondrial Creatine Kinase in Cancer Patients
Authors: T. W. Stewart
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Mitochondrial creatine kinase (CK-MIT) is an isoenzyme of creatine kinase thought to be of mitochondrial origin that migrates cathodically to the MM fraction on electrophoresis. Bark, in his report entitled "Mitochondrial Creatine Kinase" (1980;243:2058), observed CK-MIT in eight patients, most of whom suffered acute myocardial infarction. All experienced shock with poor tissue perfusion, and six of the eight died within a brief period. He concluded that the presence of CK-MIT indicated severe tissue damage, particularly myocardial, and poor prognosis. We recently detected apparent CK-MIT in two patients without heart disease or shock, both of whom had metastatic carcinoma. <h3>Report of Cases.—Case 1.—</h3> A 63-year-old man complained of low-back pain, night sweats, weakness, and a 12-kg (27-lb) weight loss over several weeks. An examination led to an exploratory laparotomy, at which time multiple nodules were found in the liver. Biopsy findings indicated malignant lymphoma. Although his
Taking Heart — Cardiac Transplantation Past, Present, and Future
Authors: Sharon A. Hunt
Journal: New England Journal of Medicine (2006)

Heart transplantation hit the international news with a splash in December 1967, when the first human-to-human transplantation was performed in South Africa by Christiaan Barnard, and the first transplantation in the United States, performed by Norman Shumway at Stanford University, followed a month later. Initial enthusiasm for the procedure was quickly curbed, however, when it became evident that survival rates were usually measured in days or weeks. This poor survival was due not to poor surgical technique, but to an inadequate understanding of the type of postoperative complications one should anticipate and a lack of tools for addressing these complications . . .
Endogenous insulin-like growth factor (IGF) binding proteins cause IGF-1 resistance in cultured fibroblasts from a patient with short stature.
Authors: S E Tollefsen, E Heath-Monnig, M A Cascieri, M L Bayne, W H Daughaday
Journal: Journal of Clinical Investigation (1991)

The ED50 of insulin-like growth factor (IGF)-I-stimulated alpha-aminoisobutyric acid (AIB) uptake (mean +/- SD) in cultured fibroblasts from a child with short stature that we have reported (1.40 +/- 0.24 nM), is significantly higher than the ED50 of IGF-I-stimulated AIB uptake in fibroblasts from 11 normal subjects (0.42 +/- 0.12 nM) and from 127 short children (0.35 +/- 0.11 nM). Similarly, the ED50 of IGF-I-stimulated thymidine incorporation in fibroblasts from this child is 2.8 times higher than that in fibroblasts from four normal subjects. To minimize potential modulation of IGF-I action by endogenous IGF binding proteins in these assays, fibroblast responsiveness to [Q3,A4,Y15,L16]IGF-I, an IGF-I variant that has a 600-fold reduced affinity for serum IGF binding proteins, has been examined. The biological activity of this variant is comparable in the patient's and normal fibroblasts, suggesting that the resistance to IGF-I action cannot be attributed to a defective IGF-I receptor. To investigate directly the possibility that IGF-I sensitivity in the patient's fibroblasts is reduced by endogenous IGF binding proteins (IGFBP), binding proteins that are secreted into AIB assay buffer during a 3-h collection and that are cell-associated at the end of the collection have been analyzed. Ligand blot analysis of conditioned AIB assay buffer demonstrates that fibroblasts from the patient secrete 1.3-2.2 times more of Mr 46,400/42,900, 32,000, and 26,800 binding proteins than normal fibroblasts. The major difference between fibroblasts from the patient and from normal subjects is a striking 10-fold increase in the amount of a cell surface Mr 32,000 binding protein in the patient's fibroblasts. The Mr 32,000 binding protein is similar in size to IGFB-1 and different from IGFBP-2 and IGFBP-3, but it does not cross-react with an antibody against IGFBP-1. We conclude that the resistance to IGF-I action in the patient's fibroblasts is caused by an abnormal production and/or cell association of IGF binding proteins.
Studies of lymphocytes in rheumatoid arthritis. I. Uptake of 125I-heat aggregated human IgG by Fc-receptor bearing lymphocytes.
Authors: P H Wooley, G S Panayi
Journal: Annals of the Rheumatic Diseases (1978)

The uptake of 125I-heat aggregated human IgG (125I-HAGG) by monocyte-free peripheral blood lymphocytes was investigated in patients with active rheumatoid arthritis (RA), inactive RA patients with other inflammatory joint diseases (ankylosing spondylitis and Still9s disease), and in normal controls. The lymphocytes of patients with RA, whether active or inactive, showed significantly raised levels of 125I-HAGG uptake when compared with normals. Patients with other inflammatory joint diseases showed normal levels of HAGG uptake. High uptake was not due to the presence of cytophilic antibodies and was not related to drug treatment, rheumatoid factor status, patient age, duration of disease, and did not correlate with disease activity. These results indicate that Fc-receptor bearing lymphocytes in patients with RA differ from those of normal subjects and patients with other inflammatory joint diseases. This difference was not due to differences in numbers of Fc-receptor bearing lymphocytes but may be due either to increased numbers of Fc-receptors on each cell or to increased avidity of such receptors for HAGG.
Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis
Authors: Qing Liu, Zhong Ping Duan, Da Kang Ha, Stig Bengmark, Jelica Kurtovic, Stephen M. Riordan
Journal: Hepatology (2004)

Minimal hepatic encephalopathy (MHE) is an important disorder that may seriously impair daily functioning and quality of life in patients with cirrhosis. Treatment with lactulose is of benefit. The possible role of synbiotics (probiotics and fermentable fiber) has not been assessed. We screened 97 consecutive cirrhotic patients without overt hepatic encephalopathy for MHE using the number connection test and measurement of brainstem auditory evoked potentials. MHE, defined by abnormality on at least one test modality, was present in 58 (60%) patients. Fifty-five of these patients with MHE were randomized to receive a synbiotic preparation (n = 20), fermentable fiber alone (n = 20), or placebo (n = 15) for 30 days. Cirrhotic patients with MHE were found to have substantial derangements in the gut microecology, with significant fecal overgrowth of potentially pathogenic Escherichia coli and Staphylococcal species. Synbiotic treatment significantly increased the fecal content of non-urease-producing Lactobacillus species at the expense of these other bacterial species. Such modulation of the gut flora was associated with a significant reduction in blood ammonia levels and reversal of MHE in 50% of patients. Synbiotic treatment was also associated with a significant reduction in endotoxemia. The Child-Turcotte-Pugh functional class improved in nearly 50% of cases. Treatment with fermentable fiber alone was also of benefit in a substantial proportion of patients. In conclusion, treatment with synbiotics or fermentable fiber is an alternative to lactulose for the management of MHE in patients with cirrhosis. (Hepatology 2004;39:1441-1449.)
Help Conserve Gamma Globulin
Authors: Alex J. Steigman
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The dosage of gamma globulin recommended for adults for the prevention of hepatitis with jaundice in the 1961 edition of the "Redbook" of the American Academy of Pediatrics has been questioned by Drs. Gellis and McComb. The Committee on Control of Infectious Diseases which is charged with the revision of the "Redbook" realizes that the optimum dose of gamma globulin for adults is not known. Although there is good evidence based on well-controlled studies that 0.01 ml. per pound of body weight is effective in preventing jaundice in children, comparable evidence is lacking in adults. Recommended dosages by various investigators and authoritative groups vary from 0.01 ml. to 0.06 ml. per pound. The Army Technical Bulletin, Medical-114, states that a dose of 0.05 ml. per pound is recommended. This dosage has been reaffirmed in March, 1961, and again in June, 1961, by the Hepatitis Subgroup of the
Case of Renal Calculus
Authors: W. H. Day
Journal: BMJ (1863)

urine, it flowed freely from the opening; for it ap- peared tolerably certain that the canal was an open urachus.I was anxious to admit the child into Guy's, to see if anything could be done for his re- lief; but the mother refused, and I consequently had no opportunity of carrying out my wishes.Cases like these are very rare, and are, therefore, worthy of a separate record.* The paini of colic is often associated with sickniess and retchiig; atnd it may occupy those parts of the abdomen which correspond t) the place of the ureters.The uirinary functionis are unadisturbed, and this is a capital poinit of distinctioni.The numbness of the thigh an(d drawing up of the testicle are sufficiently characteristic wheu tbey
A NOTE ON THE USE OF COLLOID MERCURY SULPHIDE
Authors: R. MARINKOVITCH
Journal: British Journal of Dermatology (1936)

Journal Article A NOTE ON THE USE OF COLLOID MERCURY SULPHIDE Get access R. MARINKOVITCH, M.D. R. MARINKOVITCH, M.D. Deputy Venereal Diseases Officer, City of Salford Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 48, Issue 4, 1 April 1936, Pages 194–196, https://doi.org/10.1111/j.1365-2133.1936.tb10325.x Published: 01 April 1936
Several grateful patients
Authors: Duncan I Campbell
Journal: BMJ (2006)

Patients who have previously been inactive must decide and plan for themselves how to incorporate more physical activity into their current lifestyle-for example, less sitting and more standing, less television, walking some of the way to work, gardening, and cycling.Walking initiatives in the patient's area may be useful (www.whi.org.uk).Patients may think that they have to go to exercise classes, but this may be unrealistic for their current activity levels and lifestyle.Other people may enjoy attending organised classes and the peer support this provides.Recording physical activity in a diary can be used in much the same way as a diet diary.Patients may find it difficult to attain the levels of moderate activity recommended initially, but this should be the long term goal.Although the Department of Health's recommended goals for physical activity clearly reduce the risk of cardiovascular disease for people who are overweight and obese, they are not sufficient to counteract all the ill effects of obesity.Helping someone to change their behaviour to prevent or reduce obesity requires a flexible approach tailored to that individual, with encouragement when, inevitably, setbacks occur.
A 75-Year-Old Woman With an Abdominal Aortic Aneurysm and Emphysema, 1 Year Later
Authors: Richard A. Parker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of direct to consumer pharmaceutical advertising and patients' requests on prescribing decisions: two site cross sectional survey
Authors: Barbara Mintzes, Morris L Barer, Richard L Kravitz, Arminée Kazanjian, Ken Bassett, Joel Lexchin, Robert G Evans, Richard Pan, Stephen A Marion
Journal: BMJ (2002)

Only the United States and New Zealand allow advertising of prescription drugs directed at patients.US spending on such advertising grew rapidly during the 1990s, reaching $2.47bn (£1650m) in 2000. 1 The dramatic increase in investment by the US pharmaceutical industry is evidence of an expected effect on sales.On the rationale that such advertising provides important information to consumers and patients who may benefit from advertised products, pharmaceutical manufacturers have campaigned in the European Union 2 and Canada 3 for the relaxing of current regulatory restrictions.We examined the relation between direct to consumer advertising and patients' requests for prescriptions and the relation between patients' requests and prescribing decisions.
Tc-99m Red Blood Cell Scintigraphic Detection of CMV-Induced Small Bowel Hemorrhage
Authors: Nikhil Bhagat, Nasrin V. Ghesani, Iona M. Monteiro, Debra S. Heller, Lionel S. Zuckier
Journal: Clinical Nuclear Medicine (2007)

A 4-month-old female child, recently diagnosed with parentally-acquired HIV complicated by moderate immunosuppression and pneumocystis carinii pneumonia (PCP), presented with hematochezia. A Tc-99m bleeding study was performed and demonstrated a site of brisk bleeding in the distal ileum. The patient was taken to the operating room and resection of the distal ileum revealed the presence of cytomegalovirus (CMV) enteritis. In immunocompromised children presenting with gastrointestinal (GI) hemorrhage, CMV enteritis should be considered.
The autosomal recessive isolated deafness, DFNB2, and the Usher 1B syndrome are allelic defects of the myosin-VIIA gene
Authors: Dominique Weil, Polonca Küssel, Stéphane Blanchard, Gallia Lévy, Fabienne Levi-Acobas, Mohamed Drira, Hammadi Ayadi, Christine Petit
Journal: Nature Genetics (1997)
Breach of Professional Etiquette
Authors: J. B. Maughan
Journal: BMJ (1842)

PROFES SIONAL ETIQUETTE.321 rending struggle for a profession they have not the means of attaining.I am also of opinion, that any locality which is capable of supporting a medical man, will equally well miiaintain a druggist; for even niow, in the country, this trade is combined frequently with anotlher.In my last I spoke of the expense of dis- pensing; let us look over our files at our drug bills
Subclavian vein cannulation: a new complication.
Authors: J R Allsop, A R Askew
Journal: BMJ (1975)

TABLE II-Mean (± SE of mean) plasma urate concentrations (mmol/l) in patients who suffered AMI according to whether they were given diuretics Day: 1 4 7 14Diuretics given (n = 38) 0-354 ± 0-015 0 409 ±0-021 * 0-392 +0-018 0-382 ±0-016 Diuretics not given (n = 32) 0 340 ±0-012 0-327 0-015* 0-368 ±0-018 0-368 0-018 *P<0-01.ate concentrations, may play a part in altering the renal handling of urate.These organic acids are thought to share a common secretory mechanism with urate and produce hyperuricaemia by competing with urate for this secretory site.11 12Possibly also a more rapid turnover of preformed purines or increased de novo synthesis may have produced hyperuricaemia in the AMI group.Further study is in progress to elucidate the mechanism.
GLOBAL SYSTEMIC VENTRICULAR LONGITUDINAL STRAIN IS REDUCED IN ADULTS WITH TRANSPOSITION OF THE GREAT ARTERIES AND A SYSTEMIC RIGHT VENTRICLE AND RELATES TO SUBPULMONARY VENTRICULAR FUNCTION AND ADVERSE CLINICAL OUTCOME
Authors: Jelena Radojevic, Gerhard-Paul Diller, Aleksander Kempny, Rafael Alonso-Gonzalez, Liodakis Emmanouil, Stefan Orwat, Konstantinos Dimopoulos, Lorna Swan, Wei Li, Michael A. Gatzoulis, Helmut Baumgartner
Journal: Journal of the American College of Cardiology (2011)
Active Coxsackieviral B Infection Is Associated With Disruption of Dystrophin in Endomyocardial Tissue of Patients Who Died Suddenly of Acute Myocardial Infarction
Authors: Laurent Andréoletti, Lydie Ventéo, Fatima Douche-Aourik, Frédéric Canas, Geoffroy Lorin de la Grandmaison, Jérôme Jacques, Hélène Moret, Nicolas Jovenin, Jean-François Mosnier, Mathieu Matta, Sébastien Duband, Michel Pluot, Bruno Pozzetto, Thomas Bourlet
Journal: Journal of the American College of Cardiology (2007)