tbuckley/cabot-search huggingface dataset:
Correlation of Goblet Cell Density and Mucosal Epithelial Membrane Mucin Expression with Rose Bengal Staining in Patients with Ocular Irritation
Authors: Stephen C. Pflugfelder, Scheffer C.G. Tseng, Kenichi Yoshino, Dagoberto Monroy, Carlos Felix, Brenda L. Reis
Journal: Ophthalmology (1997)

Purpose: This study was designed to compare goblet cell densities and mucosal epithelial membrane mucin (MEM) expression in impression cytology specimens obtained from control subjects and patients with one of the following clinically defined diseases: aqueous tear deficiency (ATD) associated with Sjögren syndrome, ATD not associated with Sjögren syndrome, inflammatory Meibomian gland disease associated with rosacea, and Meibomian gland atrophy. These data were correlated with ocular surface rose Bengal staining scores, Schirmer scores, and HLA-DR antigen staining of conjunctival epithelial cells. Methods: Goblet cell density and MEM expression were studied by impression imprints with immunohistochemical staining using an anti-mucosal epithelial membrane mucin antibody in the temporal and inferior bulbar and inferior tarsal conjunctiva of study subjects. Results: Goblet cell density adjacent to the temporal limbus was significantly reduced at 3 mm posterior to the temporal limbus in both aqueous tear deficiency groups compared with the other groups and in patients with Sjögren syndrome compared with all other groups. In the inferior tarsus, goblet cell density was significantly reduced in patients with non-Sjögren syndrome ATD as compared with all other groups, except those with inflammatory Meibomian gland disease. Mucosal epithelial membrane mucin expression in the bulbar and tarsal conjunctiva was absent in a greater percentage of patients with Sjögren syndrome compared with all other groups. Total ocular surface rose Bengal staining scores were significantly higher in patients with Sjögren syndrome as compared with all other groups and in patients with non-Sjögren syndrome ATD as compared with control groups. Rose Bengal staining scores and Schirmer I test results (without anesthesia) were inversely correlated with bulbar, but not tarsal, conjunctival goblet cell densities, and with the absence of bulbar conjunctival MEM expression. Conclusions: These results suggest that reduced goblet cell density and mucosal epithelial cell mucin expression could explain increased rose Bengal staining in patients with aqueous tear deficiency. In addition, MEM may be regarded as a marker for normal differentiation of ocular surface epithelia, with its absence signifying the development of squamous metaplasia.
Differential Expression of Biomarkers in Primary Non-small Cell Lung Cancer and Metastatic Sites
Authors: Carlos Gomez-Roca, Christophe M. Raynaud, Frederique Penault-Llorca, Olaf Mercier, Frederic Commo, Luc Morat, Laure Sabatier, Philipe Dartevelle, Estelle Taranchon, Benjamin Besse, Pierre Validire, Antoine Italiano, Jean-Charles Soria
Journal: Journal of Thoracic Oncology (2009)
Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain.
Authors: J S de Caestecker, A Pryde, R C Heading
Journal: Gut (1992)

Ten healthy volunteers and 13 patients with oesophageal motility disorders whose primary presenting complaint was chest pain were studied by distending an intraoesophageal balloon in 1 ml steps to the point of a sensation of discomfort. The net balloon pressure (intra-balloon pressure when inflated within the oesophagus minus the pressure recorded at the same volume outside the patient) was measured at each volume increment and the distension volume at the perception of discomfort was noted. The measurements were repeated after intravenous injection of edrophonium (80 micrograms/kg) and again after 1.2 mg intravenous atropine. Oesophageal wall compliance was similar in patients and controls, and the two groups showed a similar effect of decreased compliance with edrophonium and increased compliance after atropine. There were no significant differences between patients and controls of distending volume at perception of discomfort. Edrophonium, however, resulted in a significant reduction in distension threshold for pain (p less than 0.03) in patients. A similar though non-significant trend was seen in controls. In both controls and patients, distension volume for pain production after atropine was significantly (p less than 0.01) higher than after edrophonium. From these results and other published data, we suggest that the pain receptor for noxious stretch and after edrophonium challenge is likely to be an 9in series9 mechanoreceptor located in oesophageal longitudinal muscle.
Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke — Research for Biomarkers in Ischemic Stroke (REBIOS)
Authors: Takahiro Kuwashiro, Tetsuro Ago, Masahiro Kamouchi, Ryu Matsuo, Jun Hata, Junya Kuroda, Kenji Fukuda, Hiroshi Sugimori, Masayo Fukuhara, Hideto Awano, Tetsu Isomura, Kazuo Suzuki, Masahiro Yasaka, Yasushi Okada, Yutaka Kiyohara, Takanari Kitazono
Journal: Metabolism (2014)
Role of glutathione in hepatic bile formation during reperfusion after cold ischemia of the rat liver
Authors: Thomas A. Koeppel, Michael Trauner, Mennone Albert, Marco Arrese, Laura Rios-Velez, James L. Boyer
Journal: Journal of Hepatology (1998)

Liver reperfusion following cold ischemia is frequently associated with diminished bile flow in patients undergoing liver transplantation. Glutathione is a major determinant of bile-acid independent bile flow, and the effects of cold ischemia on biliary glutathione excretion are unknown.We examined the effects of cold ischemia (University of Wisconsin solution (4 degrees C), 24 h) with subsequent reperfusion (100 min) on biliary glutathione excretion in a recirculating system. Since glutathione might represent an important antioxidant within the biliary tract and oxidative stress in the biliary tract during reperfusion could contribute to the pathogenesis of bile duct injury after liver transplantation, we also assessed bile duct morphology in reperfused livers of mutant TR- -rats, in whom biliary excretion of glutathione is already impaired.Hepatic bile formation was diminished in reperfused Wistar rat livers after cold ischemia. Biliary glutathione concentrations and output were significantly decreased and correlated with postischemic changes in bile secretion. An increased biliary oxidized glutathione/glutathione ratio, indicating oxidative stress, was detected only immediately after the onset of reperfusion. Basal bile flow rates in TR- -rat livers which were already markedly reduced in control-perfused livers, decreased further during the early but not the later reperfusion period. Reperfusion of both Wistar and TR- -rat livers was not associated with electron microscopic evidence of bile duct damage.We conclude that impaired biliary excretion of glutathione contributes to decreased bile flow after cold ischemia. The absence of biliary glutathione does not appear to promote ultrastructural evidence of bile duct injury during reperfusion in the isolated perfused rat liver.
Dendritic cell differentiation potential of mouse monocytes: monocytes represent immediate precursors of CD8- and CD8+ splenic dendritic cells
Authors: Beatriz León, Gloria Martínez del Hoyo, Verónica Parrillas, Héctor Hernández Vargas, Paloma Sánchez-Mateos, Natividad Longo, María López-Bravo, Carlos Ardavín
Journal: Blood (2003)
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
Authors: Eugenia C. Pacheco-Pinedo, Amy C. Durham, Kathleen M. Stewart, Ashley M. Goss, Min Min Lu, Francesco J. DeMayo, Edward E. Morrisey
Journal: Journal of Clinical Investigation (2011)

Although mutations in Kras are present in 21% of lung tumors, there is a high level of heterogeneity in phenotype and outcome among patients with lung cancer bearing similar mutations, suggesting that other pathways are important. Wnt/β-catenin signaling is a known oncogenic pathway that plays a well-defined role in colon and skin cancer; however, its role in lung cancer is unclear. We have shown here that activation of Wnt/β-catenin in the bronchiolar epithelium of the adult mouse lung does not itself promote tumor development. However, concurrent activation of Wnt/β-catenin signaling and expression of a constitutively active Kras mutant (KrasG12D) led to a dramatic increase in both overall tumor number and size compared with KrasG12D alone. Activation of Wnt/β-catenin signaling altered the KrasG12D tumor phenotype, resulting in a phenotypic switch from bronchiolar epithelium to the highly proliferative distal progenitors found in the embryonic lung. This was associated with decreased E-cadherin expression at the cell surface, which may underlie the increased metastasis of tumors with active Wnt/β-catenin signaling. Together, these data suggest that activation of Wnt/β-catenin signaling can combine with other oncogenic pathways in lung epithelium to produce a more aggressive tumor phenotype by imposing an embryonic distal progenitor phenotype and by decreasing E-cadherin expression.
Reduction of CK and CK-MB indexes of infarct size by intravenous nitroglycerin.
Authors: W D Bussmann, D Passek, W Seidel, M Kaltenbach
Journal: Circulation (1981)

The effect of i.v. nitroglycerin administration on indexes of infarct size was examined in 31 patients with acute myocardial infarction. Serial creatine kinase (CK) and CK-MB isoenzyme determinations were used to calculate infarct size. Twenty-nine patients served as controls. Two subgroups of the study group were formed to evaluate differences between early and late intervention. In the first group (n = 22), continuous infusion of nitroglycerin over 48 hours was initiated within 8 hours (mean 4.5 hours) after the onset of symptoms. Peak CK activity for the nitroglycerin-treated patients (n = 9) in this subgroup was 544 U/1 vs 871 U/1 for the controls (n = 13) (p less than 0.05). The rate of CK release was reduced from 79 to 33 U/1.hr (58%), as was total CK and CK-MB release (p less than 0.02). Calculated infarct size was 69 gEq in the controls and 48 gEq in patients receiving nitroglycerin (CK-MB: 69 vs 43 gEq, p less than 0.05). In the late intervention subgroup, nitroglycerin therapy was begun more than 8 hours (mean 12.8 hours) after the onset of symptoms. Here, too, use of the agent was associated with lower peak CK and CK-MB levels as well as a reduction in calculated infarct size (p less than 0.05). Hemodynamic measurements, recorded every 4 hours, showed that nitroglycerin also reduced left ventricular filling pressure significantly and cardiac output increased. Blood pressure fell slightly, and systemic vascular resistance declined. The results indicate that i.v. nitroglycerin reduces CK and CK-MB release and thus calculated infarct size in both early and late intervention.
THE ETIOLOGY OF RICKETS
Authors: R. Lee
Journal: BMJ (1908)

<h3>Abstract</h3> Collective cell spreading takes place in spatially continuous environments, yet it is often modelled using discrete lattice-based approaches. Here, we use data from a series of cell proliferation assays, with a prostate cancer cell line, to calibrate a spatially continuous individual based model (IBM) of collective cell migration and proliferation. The IBM explicitly accounts for crowding effects by modifying the rate of movement, direction of movement, and the rate of proliferation by accounting for pair-wise interactions. Taking a Bayesian approach we estimate the free parameters in the IBM using rejection sampling on three separate, independent experimental data sets. Since the posterior distributions for each experiment are similar, we perform simulations with parameters sampled from a new posterior distribution generated by combining the three data sets. To explore the predictive power of the calibrated IBM, we forecast the evolution of a fourth experimental data set. Overall, we show how to calibrate a lattice-free IBM to experimental data, and our work highlights the importance of interactions between individuals. Despite great care taken to distribute cells as uniformly as possible experimentally, we find evidence of significant spatial clustering over short distances, suggesting that standard mean-field models could be inappropriate.
After Transplantation—The Child's Emotional Reactions
Authors: DOROTHY M. BERNSTEIN
Journal: American Journal of Psychiatry (1971)

This study examined the emotional responses and adaptation of 36 children who had received renal transplants. They were examined immediately following their hospital discharge and upon return visits to a post transplant clinic up to six years later. Of the 32 children who survived, four showed significant emotional reactions. The author stresses the need for alertness on the part of the nephrologist, surgeon, and psychiatrist in dealing with emotional problems of child transplant patients.
The relationship between chronological age and the erythemal response to ultraviolet B radiation
Authors: N.H. COX, B.L. DIFFEY, P.M. FARR
Journal: British Journal of Dermatology (1992)

Journal Article The relationship between chronological age and the erythemal response to ultraviolet B radiation Get access N.H. COX, N.H. COX Department of Dermatology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne, U.K. Dr N.H.Cox, Department of Dermatology, Cumberland Infirmary, Carlisle CA2 7HY, U.K. Search for other works by this author on: Oxford Academic Google Scholar B.L. DIFFEY, B.L. DIFFEY Department of Medical Physics, Dryburn Hospital, Durham, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.M. FARR P.M. FARR Department of Dermatology, Royal Victoria Infirmary, Newcastle‐upon‐Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 126, Issue 4, 1 April 1992, Pages 315–319, https://doi.org/10.1111/j.1365-2133.1992.tb00671.x Published: 01 April 1992
Spindle cell lipoma of the mandibular mucogingival junction: a case report of unusual oral neoplasm
Authors: Manal Abdulaziz Al Sheddi, Ahmad Assari, Hezekiah Mosadomi
Journal: International Journal of Oral Science (2014)

Spindle cell lipoma (SCL) is a benign lipomatous neoplasm typically located in the posterior neck and back of older males. It presents as a well-circumscribed mass in the buccal mucosa, tongue, floor of the mouth or hard palate. There are only two case reports of SCL in the gingiva and alveolar ridge. Here, we report a case of SCL in the mandibular mucogingival junction of a 68-year-old male. Clinical, histopathological and immunohistochemical findings are presented. Although oral SCL is rare, it should be considered in the differential diagnosis of spindle cell neoplasms occurring in the oral cavity.
A5.10 ∆4BAFF Alternative Splicing is Regulated by IFN-γ and SC35 Protein
Authors: Gabriel J Tobo‘n, Laurent Corcos, Laëtitia Le Pottier, Gwendal Dujardin, Pierre Youinou, Jacques-Olivier Pers
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The B-cell activating factor (BAFF) is a potent survival factor involved in the pathogenesis of autoimmune diseases. Recently, we reported the discovery of a new transcript for BAFF, ∆4BAFF – lacking exon 4 –, which is mainly detected in autoimmune diseases and acts as a transcription factor for its own gene. However, the mechanisms implicated in ∆4BAFF induction and up-regulation are unknown. In this study we analysed the induction and regulation of ∆4BAFF. <h3>Materials and Methods</h3> First, to study the alternative splicing of <i>BAFF</i> exon 4, we transfected a minigene construct, centred on exon 4, into RAMOS B cells. To determine the proteins implicated in exon 4 inclusion/exclusion, we co-transfected the minigene together with each of the plasmids coding for the main splicing proteins (SC35, SRp40, SRp55, SRp20 and hnRNPA1), and the ratios between exon4 inclusion/exclusion were evaluated by RT-PCR. Second, we examined the effects of different cytokines on ∆4BAFF induction. <h3>Results</h3> RAMOS cells presented exon 4 skipping (ratio inclusion/exclusion: 6.8) after minigene transfection. Following co-transfection of the minigene with coding plasmids for splicing proteins, only the overexpression of SC35 showed effect in the splicing of exon 4, promoting exon 4 inclusion (ratio: &gt;30). Incubation of different cell lines with several cytokines showed that IFN-γ was able to induce ∆4BAFF-transcript. Thus, after IFN-γ stimulation in the minigene model, the ratio inclusion/exclusion markedly decreased (1.5). IFN-γ modifies the balance between SC35 and another member of hnRNPs family (hnRNP C1/C2) favouring the alternative splicing of exon 4. <h3>Conclusions</h3> These results demonstrated that IFN-γ induces ∆4BAFF, modifying the function of SC35 protein and increasing the hnRNPC1/C2. Our study provides an expanded conceptual view of BAFF gene regulation, and contributes to a better understanding of the mechanisms involved in BAFF up-regulation in autoimmunity.
Further Observations on "Necrosing Ethmoiditis."
Authors: Ed. Woakes
Journal: BMJ (1893)

I"NECROSING ETHMOIDITIS."LJUNB 10, 1893.and citric acid, after some time, "saltish."The trapezius on the right side is much wasted, so that the right shoulder is considerably lower than the left, and the right supraspinous fossa of the scapula is flatter than the left.The right sterno-mastoid is also smaller than on the opposite side There is no deviation of the head.
Automatic External Defibrillators and Sudden Cardiac Death
Authors: Jeremy N. Ruskin
Journal: New England Journal of Medicine (1988)

Sudden cardiac arrest claims approximately 400,000 lives a year in the United States alone. It is the leading cause of death in men between 20 and 65 years of age. In the vast majority of cases, cardiac arrest is caused by the sudden onset of ventricular tachycardia, which is either sustained or, more commonly, progresses to ventricular fibrillation. Although most people who die of sudden cardiac arrest have underlying ischemic heart disease and associated left ventricular dysfunction, unexpected cardiac arrest is usually a primary electrical event not associated with a new myocardial infarction. If treated promptly, ventricular fibrillation is reversible . . .
Frequency of booster injections of allergoids
Authors: Philip S. Norman, Peter S. Creticos, David G. Marsh
Journal: Journal of Allergy and Clinical Immunology (1990)

In 1982, 43 ragweed-sensitive patients receiving maintenance injections of full doses of ragweed allergoid were selected for a study of the immunologic and clinical efJicacy of booster injections only four times a year, These patients had participated for 2 to 7 years as part of a trial of mixes of up to four allergoids to common pollens in the mid-Atlantic area tailored to each patient's skin test sensitivity.They were divided into a group (21 patients) to receive injections every 3 months and a group (22 patients) to receive injections about every 6 weeks (eight injections per year).Patients were rerandomized after 1 year so that half of each original group switched to the alternate treatment, and this program was continued until after the ragweed season of 1985.Thirty-four patients were still under study the last year.Doses, per injection, were IO0 allergoid units (I allergoid unit equals 100 PNU) of each allergen in the mixture.Symptom scores during the 8 weeks of each of the four ragweed seasons were not sign$cantly higher in the j-month treated group.IgG antibody levels to Amb a I (antigen E) were followed until early 1984 and were not signt$cantly difSerent in the two groups, even though the &week treated patients received a two times higher cumulative dose per year.Rates of local and systemic reactions (percent of injections eliciting reactions) were not different in the groups, which means that the 3-month treated group had about half as many reactions by virtue of taking half as many injections.We conclude that maintenance treatment with large doses of mixed allergoid preparations maintains effective treatment when it is administered only four timesperyear.
PREVALENCE OF ARTERIAL ANEURYSMS IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA: A REPORT FROM THE UNITED STATES REGISTRY FOR FIBROMUSCULAR DYSPLASIA
Authors: Jordan Gavin, Xiaokui Gu, Jeffrey Olin, Heather Gornik, Soo Hyun Kim, Bruce Gray, Michael Jaff, Robert McBane, Barry Katzen, Christopher White, Pamela Mace, Eva Kline–Rogers, James Froehlich
Journal: Journal of the American College of Cardiology (2013)
Randomized, controlled trial with interferon-alpha plus ribavirin with and without amantadine sulphate in patients with chronic hepatitis C relapsing after previous successful antiviral treatment
Authors: G. Teuber, M. Pascu, M. Lafrenz, H. Weidenbach, J. Schoelmrich, P. Wietzke-Braun, R. Arnold, J. Pausch, G. Lock, S. Zeuzem
Journal: Journal of Hepatology (2002)
ORAL IMMUNIZATION AGAINST THE PNEUMOCOCCUS
Authors: Victor Ross
Journal: The Journal of Experimental Medicine (1930)

1. Feeding heat killed pneumococci grown in milk produces a fair degree of immunity. 2. Feeding acid killed degraded aruvilent organisms produces little protection. 3. Feeding the desiccated, mechanically disrupted organisms creates a high degree of protection. 4. Feeding the Berkefeld filtrate of sodium glycocholate dissolved cells produce a high degree of immunity. 5. A single ingestion of this material equivalent to between 1 and 5 cc. growth is sufficient to protect a rat against 1000 to 10,000 fatal doses. Among rats fed the equivalent of 0.1 cc. an occasional one survives. 6. This degree of protection is present 48 hours after the feeding, and to a smaller extent exists in occasional animals at the end of 24 hours. 7. The treated animals are resistant to subcutaneous as well as intraperitoneal injections. 8. A single ingestion of hydrochloric acid killed pneumococci equivalent to between 1 and 5 cc. growth also protects within 48 hours against 1000 to 10,000 fatal doses intraperitoneally injected. 9. Reference is made to results obtained in preliminary experiments with human beings.
Characteristics of prostate-derived growth factors for cells of the osteoblast phenotype.
Authors: M Koutsilieris, S A Rabbani, H P Bennett, D Goltzman
Journal: Journal of Clinical Investigation (1987)

We examined the characteristics of mitogens extracted from human benign prostatic hyperplasia and prostatic adenocarcinoma tissue. Although mitogens for fetal rat skin fibroblasts as well as for rat calvarial osteoblasts and osterosarcoma cells were found, distinct entities that acted selectively in cells of the osteoblast phenotype could be obtained by sequential reverse-phase high performance liquid chromatography. Two peptides with apparent molecular weights of 10,000 and 13,000 D were derived from hyperplastic tissue, whereas a single moiety of 10,000 D was obtained from malignant tissue. These entities increased cell numbers and alkaline phosphatase activity in osteoblastlike cells consistent with effects on both growth and differentiation. Prostatic peptides did not stimulate adenylate cyclase in osteosarcoma cells. Mitogenic activity selective for osteoblastlike cells was identified in postpubertal but not prepubertal normal prostate. The results demonstrate the existence of osteoblastic growth factors in prostatic tissue whose presence may accompany postpubertal development.
Dutch murder case leads to talks with attorney general
Authors: Tony Sheldon
Journal: BMJ (2005)

Talks have begun this week between the Dutch Medical Association and the country's attorney general after the collapse in July of a murder case against a Dutch hospital doctor who gave palliative care to a dying patient.

Doctors reacted with alarm after it emerged that the doctor, Peter Vencken, had spent nine days in custody before being charged with murder after prescribing morphine and the sedative midazolam to a terminally ill patient.

Dr Vencken, a trainee anaesthetist, was on duty as casualty doctor when he treated a 77 year old man who had had a large cerebral …