tbuckley/cabot-search huggingface dataset:
Patients with fatigue in general practice: a prospective study.
Authors: L Ridsdale, A Evans, W Jerrett, S Mandalia, K Osler, H Vora
Journal: BMJ (1993)

OBJECTIVE--To describe the characteristics of patients attending their general practitioners and complaining of fatigue or being "tired all the time." DESIGN--Prospective study of cohort aged 16 years and older with follow up at two weeks and by questionnaires at two and six months. SUBJECTS--220 patients (164 women) with mean age 43 years and an age-sex matched comparison group. SETTINGS--Doctors and patients in four practices in Lancashire, Mid Glamorgan, Suffolk, and Surrey. MAIN OUTCOME MEASURES--General clinical data, results from standard group of laboratory tests, fatigue questionnaire, and 12 item general health questionnaire. RESULTS--Over twice as many patients with fatigue had high scores on the health questionnaire compared with the comparison group (156 (75%) v 69 (34%)). Results of laboratory tests were abnormal and contributed to the diagnosis in 19 patients. 59 out of 102 patients who responded had high fatigue scores six months later. Patients with persistent fatigue were more likely to have a history of anxiety or depression and to have had fatigue for more than three months on entry to the study. CONCLUSIONS--Women are particularly at risk of fatigue. The outcome is better if patients have had symptoms for three months or less or there is no history of emotional illness.
A5.30 Systemic Inflammation and B-Cells in Rheumatoid Arthritis
Authors: M Blits, S Vosslamber, J Lubbers, S de Ridder, AE Oostlander, GJ Wolbink, D van Schaardenburg, MT Nurmohamed, DM Pegtel, CL Verweij
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background and Objectives</h3> Rheumatoid arthritis (RA) is heterogeneous in clinical symptoms, clinical parameters, pathogenesis and gene expression levels. Previously, we demonstrated variation in B-cell related gene expression between RA patients. The aim was to explore the relation of B-cell related gene expression to clinical parameters of disease severity in early arthritis (EA) and established RA (esRA). <h3>Methods</h3> B-cell related gene expression (B-cell score) was determined in peripheral blood cells of 26 EA and 180 esRA patients, using multiplex real-time PCR. For the EA cohort, B-cell counts were also measured using flow cytometry. The esRA cohort was (randomly) divided into test and validation group of each 90 RA patients, with a mean DAS28 of 5.0 and 5.2, respectively. Associations were assessed between B-cell scores and the clinical disease parameters DAS28, CRP, RF, anti-CCP, nodules and erosions in all cohorts and B-cell counts only in EA cohort. Statistical testing was executed according to a bootstrap method which randomises the esRA group a 1000 times into two equally sized groups. <h3>Results</h3> We demonstrated that the B-cell score reflected the peripheral blood B-cell count (p &lt; 0.0001, r = 0.7463). In EA, the B-cell score revealed a significant negative correlation with CRP levels (p = 0.0175; r = –0.4618). In the esRA group we also observed a negative correlation between the B-cell score and CRP levels (p = 0.0006, r = –0.3542; p = 0.0096 after Benjamini-Hochberg multiple testing correction). This result was confirmed in the independent validation group (p = 0.0356; r = –0.2218). Additionally, we performed a randomisation with the bootstrap method, which showed the same significant correlations in almost all cases. However, no correlations were found between B-cell score and DAS28, RF, anti-CCP, nodules or erosions. <h3>Conclusions</h3> The B-cell score reflects the B-cell count in RA and a low B-cell count is associated with an increased marker of systemic inflammation in RA.
Caring for patients with chronic leg ulcer
Authors: C V Ruckley
Journal: BMJ (1998)

<b>Background</b>: The key measure of treatment success for <i>Mycobacterium avium</i> complex (MAC) lung disease is conversion of sputum mycobacterial cultures. Decreasing semi-quantitative mycobacterial culture scores have been interpreted, though not systematically evaluated, as predictive of culture conversion. <b>Methods</b>: Mycobacterial cultures obtained every 1-2 months for 12 months from MAC lung disease patients on therapy were evaluated with a semi-quantitative ordinal score; 0=no growth, 1=liquid media growth only; 2= &lt;50 colonies on solid media; 3-6=1+ to 4+ growth on solid media. We performed logistic regression on culture data to evaluate the predictive value of early changes in culture scores for culture conversion by 12 months. <b>Results</b>: We evaluated 180 MAC lung disease patients on therapy with mean of 13.3±7.7 cultures collected/patient. For each unit decrease in the 2<sup>nd</sup> culture result (median= 35 days from baseline culture), for each unit change in the 3<sup>rd</sup> culture result (median= 36 days from culture 2) and for each unit change in the 4<sup>th</sup> culture result (median= 113 days from culture 3), patients were, respectively 40% (p=0.002), 2 (p&lt;0.001) and 5 times (p&lt;0.001) more likely to have culture conversion. For each unit change in the difference between the baseline and 2<sup>nd</sup> cultures, and for each unit change in the difference between the baseline and 3<sup>rd</sup> cultures, patients were 9.5 (CI 4.3-21.1) and 12.1 (CI 4.8-30.3) times, respectively, more likely to have culture conversion. <b>Conclusions</b>: Early decreases in semi-quantitative culture scores are predictive of mycobacterial culture conversion for patients on therapy for MAC lung disease.
Analysis of tumor‐specific immunoglobulin gene rearrangement in peripheral blood B‐cells of multiple myeloma patients
Authors: L. Baldini, L. Cro, D. Delia, O. Chiorboli, A. Neri, A. T. Maiolo
Journal: American Journal of Hematology (1991)

Abstract The search for bone marrow clone neoplastic precursors in the peripheral blood of multiple myeloma (MM) patients has been the subject of a number of studies which, using different methodological approaches, have led to conflicting results. With the aim of contributing toward resolving this controversy, immunoglobulin (lg) gene rearrangement in the bone marrow mononuclear cells (BMMC) and B‐lymphocyte enriched peripheral cells (BePBC) of 11 appropriately selected advanced MM patients was studied by means of Southern blotting. Peripheral mononuclear cells (PBMC) and BePBC were studied immunophenotypically by evaluating the presence of cytoplasmic Ig positive cells (Cylg+) and CD19/PCA‐1 reactivity. A pattern of Ig gene rearrangement identical to that observed in the respective BMMC was found in only two patients who, moreover, had a significant number of Cylg+ cells. Ig gene rearrangement was not found in any of the remaining patients who showed no evidence of the presence of Cylg+ cells, although there were CD19/PCA‐1 positive cells. Consequently, the significance of the presence of malignant pre‐plasma cell peripheral B‐lymphocytes needs to be reconsidered and, in any case, these cells should be looked for in cell populations greatly enriched in B‐lymphocytes and, above all, completely lacking in plasma cells or Cylg+ cells.
Researchers find no link between XMRV and chronic fatigue syndrome
Authors: B. Roehr
Journal: BMJ (2012)

A study designed to find a definitive answer to the question of whether there is a link between the xenotropic murine leukaemia virus (XMRV) and chronic fatigue syndrome has come up with an unequivocal no. The answer was delivered at an 18 September news conference in New York City, and published in the online journal mBio 1.

A 2009 paper by Judy Mikovits published in the journal Science ,2 and a subsequent paper by Harvey Alter in Proceedings of the National Academies of the United States of America that identified a similar murine retrovirus, claimed to have established a causal relation with chronic fatigue syndrome.3

Mikovits subsequently was involved in convoluted …
Vertebral "Void" on Radiogallium Imaging after Radiation Therapy
Authors: RICHARD P. SPENCER, JONATHAN R. ARNOW, NAILA KAYANI, HASSANALI KASSAMALI
Journal: Clinical Nuclear Medicine (1988)

Three cases are described in which there was decreased radiogallium uptake in several vertebrae after radiation therapy. Therapeutic radiation, in addition to its known effects on bone uptake of Tc-99m phosphonates and marrow accumulation of radiocolloids, may be affecting the mechanisms of radiogallium concentration in osseous tissue.
Suicide by Rifampin Overdose
Authors: Richard O. Broadwell
Journal: JAMA (1978)

RIFAMPIN is a potent antibiotic with the capacity for serious and unusual side effects, even in therapeutic dosages.<sup>1,2</sup>Deaths in patients taking therapeutic dosages have been attributed to an unknown immunologic mechanism and have occurred almost exclusively in patients taking the drug at irregular intervals.<sup>3</sup>Massive overdose, "the red man syndrome," has been reported in one patient whose clinical course was uneventful.<sup>4</sup>We report the first case, to our knowledge, of rifampin overdose resulting in death after deliberate ingestion. <h3>Report of a Case</h3> A 26-year-old mentally retarded man had been well until 24 hours before admission, when considerable nausea, vomiting, and diffuse abdominal pain developed. He took magnesium sulfate with symptomatic improvement. However, within two hours of the onset of symptoms, an intense generalized pruritus developed. During the next 30 minutes, a faint, orange discoloration of the skin became apparent, and he was brought to the emergency
Research Reveals Low Immunization Rates and Vaccination Awareness Among Adults
Authors: Tracy Hampton
Journal: JAMA (2008)

ANEW US SURVEY REPORTS UNACceptably lowadult immunization rates and a lack of public awareness of the threat of infectious diseases, say public health officials. The most recentNationalImmunizationSurveyfrom the US Centers for Disease Control and Prevention (CDC) indicates that while mostindividualsarefamiliarwiththebenefitsof influenzavaccination,theyareunawareof themanyotherdiseases thatare preventable by immunization (http: //www.cdc.gov/nis/). In the United States alone, there are morethan1millioncasesofshingles,more than 6 million new human papillomavirus (HPV) infections, and nearly 10 000 casesofcervicalcancerdetectedannually. Incidence of pertussis also has risen significantly over the past few decades. “As of today, an American adult who followstherecommendedimmunization schedule will be protected against 14 infectiousdiseases,”saidKristinNichol,MD, MPH,of theUniversityofMinnesotaand the Minneapolis VA Medical Center and Medicine,atarecentnewsconferenceheld bytheNationalFoundationforInfectious Diseases.
Glucagon-Stimulated and Postprandial Plasma C-Peptide Values as Measures of Insulin Secretory Capacity
Authors: Pertti J Koskinen, Jorma SA Viikari, Kerttu MA Irjala
Journal: Diabetes Care (1988)

Basal, postprandial (2 h after breakfast), and glucagonstimulated plasma C-peptide concentrations were determined in a group of 36 adult diabetic patients. Basal and postprandial C-peptide values were measured on consecutive days to estimate the degree of variation of C-peptide secretion. In a subgroup of 15 diabetic patients treated chronically with diet and oral hypoglycemic agents (sulfonylureas or a combination of sulfonylureas and metformin), we studied whether administration of sulfonylureas immediately before breakfast had any effect on postprandial C-peptide values. Absolute differences between two consecutive fasting C-peptide concentrations in insulin-requiring patients were &amp;lt;0.1 nM in all but 1 patient, in whom the difference was 0.18 nM. In subjects treated with oral hypoglycemic agents the median difference was 0.12 nM (range 0-0.38 nM). Absolute differences between two consecutive postprandial C-peptide concentrations were all &amp;lt;0.1 nM in insulin-requiring patients. No significant difference was found between postprandial C-peptide concentrations with or without preceding administration of oral hypoglycemic agents (medians 1.35 and 1.30 nM, respectively). Glucagon-stimulated C-peptide concentrations were somewhat higher than the postprandial values. However, equal discrimination between insulin-requiring and non-insulin-requiring diabetic patients was found by measuring postprandial or glucagon-stimulated C-peptide concentrations.
The epidemiology of acute respiratory distress syndrome in pediatric intensive care units in China
Authors: Wen-Liang Yu, Zhu-Jin Lu, Ying Wang, Li-Ping Shi, Feng-Wu Kuang, Su-Yun Qian, Qi-Yi Zeng, Min-Hui Xie, Guo-Ying Zhang, De-Yi Zhuang, Xun-Mei Fan, Bo Sun
Journal: Intensive Care Medicine (2008)
Single-Beat Estimation of End-Systolic Elastance Using Bilinearly Approximated Time-Varying Elastance Curve
Authors: Toshiaki Shishido, Kazuko Hayashi, Kenji Shigemi, Takayuki Sato, Masaru Sugimachi, Kenji Sunagawa
Journal: Circulation (2000)

Background —Although left ventricular end-systolic elastance (E es ) has often been used as an index of contractility, technical difficulties in measuring volume and in changing loading conditions have made its clinical application somewhat limited. By approximating the time-varying elastance curve by 2 linear functions (isovolumic contraction phase and ejection phase) and estimating the slope ratio of these, we developed a method to estimate E es on a single-beat basis from pressure values, systolic time intervals, and stroke volume. Methods and Results —In 11 anesthetized dogs, we compared single-beat E es with that obtained with caval occlusion. Although the decrease (but not the increase) in contractility (5.3 to 11.4 mm Hg/mL) and the change in loading conditions (3.7 to 34.0 mm Hg/mL) over wide ranges significantly altered the slope ratio, the estimation of E es was reasonably accurate ( y =0.97 x +0.46, r =0.929, SEE=2.1 mm Hg/mL). Conclusions —E es can be estimated on a single-beat basis from easily obtainable variables by approximating the time-varying elastance curve by a bilinear function.
Localization of Aminoacridine Fluorescence in Lung Tumors of Rats
Authors: Norman B. Ackerman, Alvin Shemesh
Journal: JAMA (1964)

ACRIDINE ORANGE has been used for years as a supravital stain for localization of nucleic acids. This dye is relatively nontoxic when given to the living animal, and it causes an intense staining of the ribonucleic acids of the nucleolus and of the desoxyribonucleic acids of the nucleus.<sup>1,2</sup>Studies were initiated in this laboratory on the uptake of acridine orange and other aminoacridine compounds by tumors in animals. Many of these compounds were screened by Lewis and associates in the late 1940's for cancer chemotherapy properties, and, although the results were not especially striking, gross staining of the tumors was noted following the administration of some of the compounds.<sup>3, 4</sup>The aminoacridine chemicals are an interesting group; they include antimalarial and antiparasitic drugs such as quinacrine (Atabrine) hydrochloride and diethylaminoethylamino-4-methylthiaxanthone hydrochloride (Miracil D), antibacterial agents (proflavine and acriflavine), and numerous commercial and laboratory dyes. Most of these chemicals are brightly
A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster
Authors: Xueqing Zhang, Zheng Lian, Carolyn Padden, Mark B. Gerstein, Joel Rozowsky, Michael Snyder, Thomas R. Gingeras, Philipp Kapranov, Sherman M. Weissman, Peter E. Newburger
Journal: Blood (2009)
TCT-827 Interaction Between Perivalvular aortic regurgitation and delivery approach: Impact on clinical outcome after TAVI - Insights from the France 2 Registry
Authors: Eric Van Belle, Francis Juthier, Pierre - Yves Litzler, Martine Gilard, Helene Eltchaninoff, Bernard Lung, Carlo Banfi, Pascal Leprince, Jean Fajadet, Alain Leguerrier, Alain Prat, Marc Laskar, Emmanuel Teiger
Journal: Journal of the American College of Cardiology (2012)
Sudden Cardiac Death without Warning
Authors: Stephen E. Epstein, Arshed A. Quyyumi, Robert O. Bonow
Journal: New England Journal of Medicine (1989)

Sudden death or acute and extensive myocardial infarction are common presenting manifestations of coronary artery disease.1 , 2 In attempting to determine whether screening tests can identify persons at risk of sudden death, three studies in which asymptomatic subjects were followed prospectively after having undergone electrocardiographic exercise stress testing demonstrated a fascinating but disturbing fact.3 4 5 6 As expected, asymptomatic subjects with normal results on stress tests had a much lower mortality rate than asymptomatic subjects with abnormal results. However, the very large low-risk group with normal responses to exercise testing (constituting about 95 percent of the entire cohort) contained, in absolute terms, the . . .
High Expression of Karyopherin-α2 Defines Poor Prognosis in Non–Muscle-Invasive Bladder Cancer and in Patients with Invasive Bladder Cancer Undergoing Radical Cystectomy
Authors: Jørgen Bjerggaard Jensen, Pia Pinholt Munksgaard, Christoffer Mørk Sørensen, Niels Fristrup, Karin Birkenkamp-Demtroder, Benedicte Parm Ulhøi, Klaus Møller-Ernst Jensen, Torben F. Ørntoft, Lars Dyrskjøt
Journal: European Urology (2011)
Nonparoxysmal Junctional Tachycardia Complicating Acute Myocardial Infarction
Authors: LEE L. KONECKE, SUZANNE B. KNOEBEL
Journal: Circulation (1972)

Twenty-one instances of nonparoxysmal junctional tachycardia (NPJT) were observed in 203 consecutive patients with acute myocardial infarction. The arrhythmia complicated both anterior and inferior wall infarction and was associated with an ominous prognosis, particularly in patients with anteror wall infarction. The NPJT is probably a manifestation of the severity of the lesion. The exact mechanisms of the enhanced A-V junctional activity remain obscure. The possible role of increased levels of epinephrine and norepinephrine and localized increases of potassium in the A-V junction from adjacent necrotic myocardium is suggested.
Changes in airways conductance on smoking a cigarette: A study of repeatability and of the effect of particulate and vapour phase filters
Authors: B. G. Clarke, A. R. Guyatt, J. H. Alpers, C. M. Fletcher, I. D. Hill
Journal: Thorax (1970)

Measurements of airways conductance using a body plethysmograph were made on 25 men before and after smoking one cigarette on each of four days and before and after a control period without smoking on another day. The repeatability of these measurements and of the bronchoconstrictor effect of smoking was studied. The variance was as great as that observed in a previous field study in industry despite close supervision and a stable environment before the measurements. We think this variation is due to random fluctuation rather than to the lack of close supervision inevitable in a field survey. A second study was made on 16 of the men in which the bronchoconstrictor effect of plain and filtered cigarettes was compared. Filters which removed either the particulate or the vapour phase of the smoke had a similar effect in reducing the bronchoconstrictor response of cigarette smoking.
Study of the Cardiac Arrhythmias by the Ultrasonic Doppler Method
Authors: SAMUEL BELLET, JOHN KOSTIS
Journal: Circulation (1968)

The Doppler tracing is a sensitive method for depicting movement of the heart wall, valves, and blood flow. This communication reports the authors' experience with the Doppler method in normal persons and patients with various cardiac arrhythmias. Three main components are recognized in the Doppler tracing: the presystolic component, a ; component v s due to systolic movement of the ventricles; and component v d corresponding to the movement of ventricles during early diastole. Evidence is presented that component a is due to atrial contraction. This has been substantiated in this study by the simultaneous recording of the Doppler tracing with the electrocardiogram, phonocardiogram, apex cardiogram, jugular venous tracing, right atrial pressure tracing, and the inscription of the Doppler tracing frame by frame in the right atrial cineangiocardiogram. These findings are of interest since they introduce a relatively new method of studying cardiac wall movement, particularly that of the right atrium. In addition, simultaneous recording of the Doppler tracing of the atria with the electrocardiogram may be of help in the diagnosis of certain cardiac arrhythmias.
Transcription Factor SCL Is Required for c-kit Expression and c-Kit Function in Hemopoietic Cells
Authors: Gorazd Krosl, Gang He, Martin Lefrancois, Frédéric Charron, Paul-Henri Roméo, Paul Jolicoeur, Ilan R. Kirsch, Mona Nemer, Trang Hoang
Journal: The Journal of Experimental Medicine (1998)

In normal hemopoietic cells that are dependent on specific growth factors for cell survival, the expression of the basic helix-loop-helix transcription factor SCL/Tal1 correlates with that of c-Kit, the receptor for Steel factor (SF) or stem cell factor. To address the possibility that SCL may function upstream of c-kit, we sought to modulate endogenous SCL function in the CD34+ hemopoietic cell line TF-1, which requires SF, granulocyte/macrophage colony–stimulating factor, or interleukin 3 for survival. Ectopic expression of an antisense SCL cDNA (as-SCL) or a dominant negative SCL (dn-SCL) in these cells impaired SCL DNA binding activity, and prevented the suppression of apoptosis by SF only, indicating that SCL is required for c-Kit–dependent cell survival. Consistent with the lack of response to SF, the level of c-kit mRNA and c-Kit protein was significantly and specifically reduced in as-SCL– or dn-SCL– expressing cells. c-kit mRNA, c-kit promoter activity, and the response to SF were rescued by SCL overexpression in the antisense or dn-SCL transfectants. Furthermore, ectopic c-kit expression in as-SCL transfectants is sufficient to restore cell survival in response to SF. Finally, enforced SCL in the pro–B cell line Ba/F3, which is both SCL and c-kit negative is sufficient to induce c-Kit and SF responsiveness. Together, these results indicate that c-kit, a gene that is essential for the survival of primitive hemopoietic cells, is a downstream target of the transcription factor SCL.
A Brighter Future for Patients With Amyotrophic Lateral Sclerosis Through Imaging?
Authors: Bradley R. Foerster, Eva L. Feldman
Journal: JAMA Neurology (2014)

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