tbuckley/cabot-search huggingface dataset:
Anaerobic Septic Bursitis
Authors: DAVID J. TOLLERUD
Journal: Annals of Internal Medicine (1979)

Letters1 September 1979Anaerobic Septic BursitisDAVID J. TOLLERUD, M.D., LORRAINE ALBANO, B.A., FRANK J. BIA, M.D.DAVID J. TOLLERUD, M.D.Search for more papers by this author, LORRAINE ALBANO, B.A.Search for more papers by this author, FRANK J. BIA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-3-494_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their excellent article on septic bursitis in the prepatellar and olecranon bursae, Ho, Tice, and Kaplan (1) reported 24 culture-positive cases of septic bursitis, 22 withStaphylococcus aureusand two with group A, beta-hemolytic streptococci, and at least two culture-negative cases in patients taking antibiotics. This distribution is corroborated by their review of the literature and a subsequent report (2). Isolated cases of septic bursitis involving other organisms were noted, includingMycobacterium marinum, Sporothrix schenckii, and achloric algae. Notably absent were reports of anaerobic bursitis, in contrast to the well-documented association of anaerobic organisms with bone...References1. HO G, TICE A, and KAPLAN S. Septic bursitis in the prepatellar and olecranon bursae: an analysis of 25 cases. Ann Intern Med. 1978; 89:21-7. LinkGoogle Scholar2. THOMPSON G, MANSHADY B, and WEISS J. Septic bursitis. JAMA. 1978; 240:2280-1. CrossrefMedlineGoogle Scholar3. LEWIS R, SUTTER V, and FINEGOLD S. Bone infections involving anaerobic bacteria. Medicine (Baltimore). 1978;57:279-305. CrossrefMedlineGoogle Scholar4. RAFF M and MELO J. Anaerobic osteomyelitis. Medicine (Baltimore). 1978; 57:83-103. CrossrefMedlineGoogle Scholar5. MARTIN W. Human infection with B. necrophorum. AM J Clin Pathol. 1940; 10:567-75. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID J. TOLLERUD, M.D.; LORRAINE ALBANO, B.A.; FRANK J. BIA, M.D.Affiliations: Yale University School of Medicine New Haven, CT 06510 West Haven Veterans Administration Medical Center West Haven, CT 06516 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBursopatías: etiopatogenia, diagnóstico y tratamientoSeptic ArthritisSoft tissue diseaseEntzündungen bekannter ÄtiologieSeptic bursitisSOFT TISSUE INFECTIONSSEPTIC BURSITIS: EXPERIENCE IN A COMMUNITY PRACTICEInfections of Bursae and TendonsKrankheiten der SchleimbeutelBacterial Infection of the Superficial Subcutaneous BursaePredisposing Factors, Bacteriology and Antibiotic Therapy in 35 Cases of Septic BursitisAn Overview of Septic Arthritis and Septic Bursitis 1 September 1979Volume 91, Issue 3Page: 494-494KeywordsAntibioticsBoneGroup A streptococciStaphylococcus aureus ePublished: 1 December 2008 Issue Published: 1 September 1979 PDF downloadLoading ...
Cut to the core
Authors: F. Godlee
Journal: BMJ (2013)

The costs and quality of hospital care are under scrutiny as never before. How should we decide which types of secondary care represent value for money, how should we pay for them, and which treatments should be included in a tax funded service, free at the point of care (as the NHS still purports to be)?

In the first of a two part BMJ investigation, Gareth Iacobucci lifts the lid on England’s clinical commissioning groups (CCGs) as they take control of the purse strings for hospital care (doi:10.1136/bmj.f4351). Through freedom of information requests, he finds that CCGs are …
Detection of left ventricular asynchrony in patients with right bundle branch block after repair of tetralogy of Fallot using tissue-Doppler imaging-derived strain
Authors: Mohamed Y. Abd El Rahman, Wei Hui, Moustafa Yigitbasi, Fatima Dsebissowa, Stephan Schubert, Roland Hetzer, Peter E. Lange, Hashim Abdul-Khaliq
Journal: Journal of the American College of Cardiology (2005)
Benign mucous-membrane pemphigoid associated with penicillamine treatment.
Authors: J S Pegum, A C Pembroke
Journal: BMJ (1977)

3 h after the dose either before or after 10 days of drug administration.Isolated increases in plasma GH levels were noticed during the 10 days of treatment with BS 100-141 but were probably not drug-induced.No side effects were recorded.Blood pressure fell by a mean of 20'30 mm Hg.
IN PATIENTS WITH ANTERIOR ST ELEVATION MYOCARDIAL INFARCTION ST DEPRESSION IN V5 AND V6 IS A PREDICTOR OF THREE-VESSEL DISEASE
Authors: Gaetano Maria De Ferrari, Claudia Pavesi, Silvia Salaro, Gabriele Crimi, Silvia Pica, Antonella Potenza, Maurizio Ferrario
Journal: Journal of the American College of Cardiology (2011)
Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules.
Authors: E Nössner, P Parham
Journal: The Journal of Experimental Medicine (1995)

Previous studies have shown that immature mouse class I molecules transiently associate with a resident endoplasmic reticulum protein of 88 kD that has been proposed to act as a chaperone for class I assembly. Subsequently, this protein was demonstrated to be identical to calnexin and to associate with immature forms of the T cell receptor complex, immunoglobulin, and human class I HLA heavy chains. In this paper we define further the interaction of human class I HLA heavy chains with chaperone proteins and find key differences with the complexes observed in the mouse system. First, calnexin and immunoglobulin binding protein (BiP) both associate with immature HLA class I heavy chains. The two chaperones are not found within the same molecular complex, suggesting that calnexin and BiP do not interact simultaneously with the same HLA class I heavy chain. Second, only free HLA class I heavy chains, and not beta 2-microglobulin (beta 2m)-associated heavy chains are found associated with the chaperones. Indeed, addition of free beta 2m in vitro induces dissociation of chaperone-class I HLA heavy chain complexes. The kinetics for dissociation of the class I HLA heavy chain-chaperone complexes and for formation of the class I HLA heavy chain-beta 2m complex display a reciprocity that suggests the interactions with chaperone and beta 2m are mutually exclusive. Mouse class I heavy chains expressed in human cells exhibit the mouse pattern of interaction with human chaperones and human beta 2m and not the human pattern, showing the difference in behavior is purely a function of the class I heavy chain sequence.
Allogeneic and autologous stem cell transplantation for hepatosplenic T-cell lymphoma: a retrospective study of the EBMT Lymphoma Working Party
Authors: A Tanase, N Schmitz, H Stein, A Boumendil, H Finel, L Castagna, D Blaise, N Milpied, G Sucak, A Sureda, K Thomson, E Vandenberghe, A Vitek, P Dreger
Journal: Leukemia (2014)
New drugs strategy for England focuses on recovery not abstinence
Authors: J. Wise
Journal: BMJ (2010)

The new drugs strategy for England stops short of the abstinence based policy demanded by some on the Tory right but instead focuses on recovery.

The Conservative Party manifesto had criticised existing treatment programmes, saying that too many people received methadone that maintained their habit. Some on the right of the party had called for cuts in benefits for drug users who refuse treatment. But the new coalition strategy has shied away from taking such a hard line approach.

Launching the strategy, the public health minister, Anne Milton, said: “Recovery is at the heart of our new approach. As set out in our white paper, the system will be locally owned and led by directors of public health and local government. We will work with individuals and their families to offer them a clear route out of dependence.”

The strategy’s emphasis on recovery is along the same lines as the Scottish drugs strategy launched in 2007 and …
Patients' Attitudes to Medical Students in General Practice
Authors: H. J. Wright
Journal: BMJ (1974)

259 consecutive adult patients were interviewed regarding their attitudes to the presence of medical students at consultation, at examination, and at home visits. Few patients declared reluctance to discussing physical illness and smoking or drinking problems in the student9s presence, but many had appreciable inhibitions about discussing almost every other common component of consultation. Over half of the younger women interviewed would prefer students not to be present at physical or pelvic examination. Neither age nor social class showed significant association with declared preference, but previous contact with students did not decrease inhibitions among patients. Only 15% of respondents said that they would be more upset by the presence of two students rather than one.
Viral Hepatitis, Type B
Authors: Saul Krugman, Jay H. Hoofnagle, Rogert J. Gerety, Paul M. Kaplan, John L. Gerin
Journal: New England Journal of Medicine (1974)

Serial serum samples from immunized and unimmunized persons exposed to the MS-2 strain of hepatitis B virus were tested for DNA polymerase and antibody to hepatitis B core antigen (anti-HBc). First DNA polymerase and then antibody to the core antigen appeared in unimmunized persons after hepatitis B surface antigen and before or at the time of elevated liver enzymes. DNA polymerase persisted for days or weeks in acute cases and for months or years in chronic carriers, whereas antibody to hepatitis B core antigen persisted in all cases. Neither hepatitis B surface antigen, DNA polymerase, nor antibody to core antigen appeared in persons immunized with heat-inactivated MS-2. Hepatitis B surface antigen and DNA polymerase were not detected in those passively immunized with hepatitis B immune globulin, but antibody to core antigen did appear transiently in one. Thus, DNA polymerase appears to identify the period of peak hepatitis B virus replication, antibody to core antigen reflects recent or ongoing virus replication, and both tests will be useful in evaluating the safety and efficacy of future hepatitis B virus vaccines. (N Engl J Med 290:1331–1335, 1974)
Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells
Authors: Hisamitsu Ishihara, Haiyan Wang, Lester R. Drewes, Claes B. Wollheim
Journal: Journal of Clinical Investigation (1999)

Previous investigations revealed low activities of lactate dehydrogenase (LDH) and plasma membrane monocarboxylate transporters (MCT) in the pancreatic β cell. In this study the significance of these characteristics was explored by overexpressing type A LDH (LDH-A) and/or type 1 MCT (MCT-1) in the clonal INS-1 β cells and isolated rat islets. Inducible overexpression of LDH-A resulted in an 87-fold increase in LDH activity in INS-1 cells. Adenovirus-mediated overexpression of MCT-1 increased lactate transport activity 3.7-fold in INS-1 cells. Although overexpression of LDH-A, and/or MCT-1 did not affect glucose-stimulated insulin secretion, LDH-A overexpression resulted in stimulation of insulin secretion even at a low lactate concentration with a concomitant increase in its oxidation in INS-1 cells regardless of MCT-1 co-overexpression. Adenovirus-mediated overexpression of MCT-1 caused an increase in pyruvate oxidation and conferred pyruvate-stimulated insulin release to isolated rat islets. Although lactate did not stimulate insulin secretion from control or MCT-1–overexpressing islets, co-overexpression of LDH-A and MCT-1 evoked lactate-stimulated insulin secretion with a concomitant increase in lactate oxidation in rat islets. These results suggest that low expression of MCT and LDH is requisite to the specificity of glucose in insulin secretion, protecting the organism from undesired hypoglycemic actions of pyruvate and lactate during exercise and other catabolic states.
TINNITUS IN ITS RELATION TO NASAL AND AURAL AFFECTIONS.
Authors: B. ALEXANDER RANDALL
Journal: JAMA (1898)

This is a topic which appeals to all of us and it is important that clear views should be obtained of it so far as possible. The division into the objective and subjective forms is hardly worth mentioning, and yet we should remember that there is a large amount of objective tinnitus present in aneurysm, etc. Several cases bring clearly to my mind how easy it is to ignore this matter. It is inevitable that we should have a large bruit ever present, and if an anemic condition gives rise to anemic heart-sounds it may result in similar murmurs in the ear. It is important in turning to the subjective symptoms, to remember that there are at least five points where this condition may arise, marking the cerebral, the labyrinthine, the tympanic, the tubal and the purely nasal forms. With this distinction it is clear that we are all interested
Selective In Situ Parasympathetic Control of the Canine Sinoatrial and Atrioventricular Nodes
Authors: RALPH LAZZARA, BENJAMIN J. SCHERLAG, MORTON J. ROBINSON, PHILIP SAMET
Journal: Circulation Research (1973)

Methods were devised for the selective alteration of parasympathetic control over the sinoatrial (SA) or the atrioventricular (AV) node in anesthetized, thoracotomized mongrel dogs. Two epicardial sites were located at which parasympathetic nerve fibers enroute to the SA or the AV node could be stimulated or blocked. Selective nerve stimulation was accomplished with brief pulses (0.05 msec), and blockade was accomplished with topically applied lidocaine. At the intercaval site, only the SA node was affected. At the site near the coronary sinus ostium, only the AV node was affected in terms of parasympathetic control, but sometimes there were modest sympathetic effects on the SA node. The effects of stimulation at these sites, except for the SA speeding produced by stimulation at the site near the coronary sinus, were blocked by atropine. The effects were also blocked by ganglionic blockade. Probably, preganglionic parasympathetic fibers to the nodes are concentrated at these sites.
The Burden of Diabetes (Care)
Authors: Irl B. Hirsch
Journal: Diabetes Care (2003)

Now that there is a plethora of clinical trial data with clinically meaningful end points proving that the burden of diabetes can be improved by a variety of interventions, including glycemic, blood pressure, and lipid control; the use of statins, ACE inhibitors, and aspirin; appropriately timed laser therapy for diabetic retinopathy; and screening of feet at high risk for neuropathic ulcers, it is now time to evaluate just how well we do with our current level of care. Over the past few years, there have been a variety of surveys indicating that despite our evidenced-based clinical trial data, diabetes care in the U.S. has been abysmal. Several of these reports have focused on levels of diabetes care comparing how providers of different specialties (and their patients) performed when compared with each other (1–4) in addition to the national standards. The ensuing discussions and controversies did not really address the major problem: all of the providers provided less-than-optimal care, and although there are many reasons for this, perhaps the most important one is the fact that our current systems of diabetes care make outstanding management for all difficult, if not impossible. Unfortunately, many providers confuse the “burden of diabetes,” which refers to diabetes-related morbidity and mortality issues, with the “burden of diabetes care.” This latter concept is all too prevalent for too many physicians. These patients are complex, often do not take the best care of themselves, require multiple medications, and, importantly, often require follow-up between visits. For a primary care provider who may be allowed 10 or, at the most, 15 min to see this patient (an impossible task even with twice as much time), seeing many of these patients is truly …
Aspirin Increases Blood Alcohol Concentrations in Humans After Ingestion of Ethanol
Authors: Risto Roine
Journal: JAMA (1990)

Gastric first-pass metabolism of ethanol is an important determinant of blood alcohol concentrations. We studied five healthy volunteers after ingestion of ethanol (0.3 g/kg of body weight) and found that blood alcohol concentrations in the fed state (ie, 1 hour after a standard breakfast) were significantly higher when the subjects received 1 g of aspirin 1 hour before ingestion of ethanol than without the drug. In vitro, aspirin clearly decreased the activity of gastric alcohol dehydrogenase in human subjects and in rat models, but not that of hepatic alcohol dehydrogenase in rats. Furthermore, blood alcohol concentrations in rats were unaffected by ingestion of aspirin when ethanol was infused intravenously. Thus, aspirin may increase the bioavailability of ingested ethanol in humans, possibly by reducing ethanol oxidation by gastric alcohol dehydrogenase.
Decreased Insulitis and Blood Glucose Levels after Injection of GAD-Transduced Lymphocytes into NOD Mice
Authors: Fengchun Li, Maria Filippova, Omar Fagoaga, Sandra Nehlsen-Cannarella, Alan Escher
Journal: Molecular Therapy (2002)

We used NOD mice to investigate the effects of injecting transduced lymphocytes on insulitis, nonfasting blood glucose levels, and immune responses. Syngeneic splenocytes were transduced with retroviral particles carrying a cDNA construct encoding the β cell antigen glutamic acid decarboxylase (GAD65), a secreted form of GAD65 (SGAD55), or secreted alkaline phosphatase (SEAP) as a control antigen. Different multiplicities of infection (m.o.i.) were used with different constructs. Four-week-old NOD mice received intravenous injection of CD4+ cells isolated from transduced splenocytes, and insulitis and blood glucose levels were determined at 10 weeks of age. No significant effects were observed with lymphocytes transduced with gad65 and sgad55 constructs at low m.o.i. By contrast, at high m.o.i., lymphocytes transduced with the sgad55 and seap constructs caused a decrease in insulitis and blood glucose levels and in insulitis alone, respectively. ELISA of anti-GAD antibody isotypes indicated that GAD-transduced lymphocytes induced similar Th2-like responses at all m.o.i. These results suggest that retroviral particles carrying sgad55 can be used for engineering cell vaccines for type 1 diabetes and provide further evidence that Th2-like responses induced by immunization may not always be a primary cause of diabetes suppression in NOD mice.
P2-264: Impact of gender on median overall survival (MOS) in patients with advanced non–small cell lung cancer (NSCLC) treated with platinum–based chemotherapy– Single center experience
Authors: Kian Khodadad, Azadeh Zakeri, Mohammad R. Masjedi, Mojgan Padyab, Habib Emami
Journal: Journal of Thoracic Oncology (2007)
Attenuated neutrophil axis in atopic dermatitis compared to psoriasis reflects TH17 pathway differences between these diseases
Authors: Nikhil Dhingra, Mayte Suárez-Fariñas, Judilyn Fuentes-Duculan, Julia K. Gittler, Avner Shemer, Assaf Raz, Vincent A. Fischetti, James G. Krueger, Emma Guttman-Yassky
Journal: Journal of Allergy and Clinical Immunology (2013)
Preliminary Results of Gene Therapy for Retinal Degeneration
Authors: Joan W. Miller
Journal: New England Journal of Medicine (2008)

In this issue of the Journal, two groups of investigators — Bainbridge et al.1 and Maguire et al.2 — describe the first results of separate clinical trials investigating the short-term safety and preliminary efficacy of gene therapy for Leber's congenital amaurosis. Both groups present short-term data (12 months and 5 months, respectively) on three patients with Leber's congenital amaurosis in each study; the patients were enrolled in trials of recombinant adeno-associated viral delivery of the human retinal pigment epithelium-specific 65-kDa protein gene (RPE65), which was administered as a subretinal injection during vitrectomy.Originally described by Leber in 1869, . . .
Tinel's Percussion Test For Intraspinal Sensory Nerve Root Involvement
Authors: Michael Scott
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Although Tinel in 1915 introduced the percussion sign, known by his name, to evaluate interruption or regeneration of a peripheral nerve, a review of his original paper and recent texts on neurological diagnosis reveals no mention of this percussion test to diagnose or localize intraspinal sensory nerve root involvement.<sup>1-3</sup> The purpose of this letter is to recommend the use of finger tapping or percussion along the course of a sensory dermatomere to elicit the sensation of "tingling" or "pins and needles" or paresthesias, as an additional or corroboratory sign, of irritation or involvement of a specific spinal sensory nerve root supplying the percussed dermatomere. For example, if the sixth cervical root in involved intraspinally by intrinsic nerve pathologic condition or by pressure from a disk, osteophyte, or tumor, the patient will often complain of pain referred to the sensory dermatomere supplied by this cervical root, namely
Biological Therapies for Cardiac Arrhythmias
Authors: Hee Cheol Cho, Eduardo Marbán
Journal: Circulation Research (2010)

Abstract: Cardiac rhythm disorders reflect failures of impulse generation and/or conduction. With the exception of ablation methods that yield selective endocardial destruction, present therapies are nonspecific and/or palliative. Progress in understanding the underlying biology opens up prospects for new alternatives. This article reviews the present state of the art in gene- and cell-based therapies to correct cardiac rhythm disturbances. We begin with the rationale for such approaches, briefly discuss efforts to address aspects of tachyarrhythmia, and review advances in creating a biological pacemaker to cure bradyarrhythmia. Insights gained bring the field closer to a paradigm shift away from devices and drugs, and toward biologics, in the treatment of rhythm disorders.
Proposed Rule Aims to Protect Workers Exposed to Crystalline Silica
Authors: Mike Mitka
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal