tbuckley/cabot-search huggingface dataset:
Electrophysiological Documentation of Bilateral Bundle Branch Block as the Common Cause of Complete Heart Block.
Authors: Charles Steiner
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Electrophysiological Documentation of Bilateral Bundle Branch Block as the Common Cause of Complete Heart Block.Charles Steiner, M.D., Sun H. Lau, M.D., Emanuel Stein, M.D., F.A.C.P., Andrew L. Wit, Ph.D., Melvin B. Weiss, M.D., Anthony N. Damato, M.D., Jacob I. Haft, M.D.Charles Steiner, M.D.Search for more papers by this author, Sun H. Lau, M.D.Search for more papers by this author, Emanuel Stein, M.D., F.A.C.P.Search for more papers by this author, Andrew L. Wit, Ph.D.Search for more papers by this author, Melvin B. Weiss, M.D.Search for more papers by this author, Anthony N. Damato, M.D.Search for more papers by this author, Jacob I. Haft, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-778_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent pathological and serial ECG studies have suggested that many cases of complete heart block may be due to bilateral block in the bundle branches rather than block in the AV node. The technique of recording the His bundle electrogram with a catheter allows the site of AV block to be differentiated into that occurring proximal or distal to the common bundle. In 16 elderly patients in chronic complete heart block studied at the time of insertion of a permanent pacemaker or at the time of a battery change the block was proximal to the His in only 2 patients... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Charles Steiner, M.D.; Sun H. Lau, M.D.; Emanuel Stein, M.D., F.A.C.P.; Andrew L. Wit, Ph.D.; Melvin B. Weiss, M.D.; Anthony N. Damato, M.D.; Jacob I. Haft, M.D.Affiliations: Staten Island and Bronx, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssessment of atrioventricular conduction in left and right bundle branch block using his bundle electrograms and atrial pacing 1 May 1970Volume 72, Issue 5Page: 778-778KeywordsCathetersElderlyElectrophysiological techniquesHeartLongitudinal studiesPacemakers ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
BCG Vaccination for American Indians
Authors: RONALD E. PUST
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 December 1970BCG Vaccination for American IndiansRONALD E. PUST, M.D.RONALD E. PUST, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-6-1043 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Concern regarding tuberculosis in the first Americans continues to be appropriate. In their letter Dr. MacGregor and associates (August 1970 ANNALS) urged "the widespread use of . . . BCG. vaccination" in the American Indian and Eskimo populations. Using as a point of departure Dr. Donald W. Smith's review of Bacillus Calmette Guérin (BCG) in the March issue (1), they cite the Indians' higher incidence of active tuberculosis (which may reach 2 per 1,000 yearly as compared with 0.2 per 1,000 in the overall U.S. population) as well as personal clinical experience in Seattle with former reservation...References1. SMITH D: Why not vaccinate against tuberculosis? Ann Intern Med 72:419-422, 1970 LinkGoogle Scholar2. TODERLUND K: BCG-induced allergy and immunity in guinea pigs during the first year after vaccination. Bull WHO 36:747, 1967 MedlineGoogle Scholar3. HART P, SUTHERLAND I, and THOMAS J: The immunity conferred by effective BCG and vole bacillus vaccines, in relation to individual variations in induced tuberculin sensitivity and to technical variations in the vaccine. Tubercle 48:201, 1967 CrossrefGoogle Scholar4. ARONSON J, ARONSON C, and TAYLOR H: A twenty-year appraisal of BCG vaccination in the control of tuberculosis. Arch Intern Med (Chicago) 101:881, 1958 CrossrefGoogle Scholar5. EDWARDS L: An atlas of sensitivity to tuberculin, PPD-B, and histoplasmin in the United States. Amer Rev Resp Dis 99 (suppl), 1969 Google Scholar6. PUST R: Unpublished observations, 1970 Google Scholar7. HART P: Efficacy and applicability of mass BCG vaccination in tuberculosis control. Brit Med J 1:587, 1967 CrossrefMedlineGoogle Scholar8. SPRINGETT V: The value of BCG vaccination. Tubercle 46: 76, 1965 CrossrefMedlineGoogle Scholar9. DEUSCHLE K: Tuberculosis among the Navajo. Amer Rev Resp Dis 80:200, 1959 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RONALD E. PUST, M.D.Affiliations: Navajo Area Indian Health Service Window Rock, Ariz. 86515 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1970Volume 73, Issue 6Page: 1043-1044KeywordsBacille calmette guerinBacillusNative American peoplePopulation statistics ePublished: 1 December 2008 Issue Published: 1 December 1970 PDF downloadLoading ...
Autoregulation of cardiac output by passive elastic characteristics of the vascular capacitance system.
Authors: C F Rothe, M L Gaddis
Journal: Circulation (1990)

After a change in cardiac output, the magnitude of potential blood volume redistribution was investigated in 10 dogs anesthetized with chloralose. All of the venous return was pumped into a reservoir, using servocontrolled pumps to maintain fixed superior and inferior vena cava pressures. The cardiac output was set at various levels by pumping from the reservoir into the right atrium. Changes in reservoir volume were assumed to reflect the changes in vascular blood volume. After measuring the control responses, cardiovascular reflexes were blocked with hexamethonium. Reducing the cardiac output, for example, from 110 to 80 ml/(min.kg) with reflexes intact, caused a 9.2-ml/kg transfer of blood from the dog to the reservoir. With reflexes blocked, the same change in cardiac output caused 6.8 ml/kg of the blood to be transferred. Under the control conditions, throughout the range of 50-140 ml/(min.kg), an increase or decrease of cardiac output of 1 ml/(min.kg) elicited a 0.304 +/- 0.086 (mean +/- SD) ml/kg change in dog blood volume; with reflexes blocked, the flow sensitivity was 0.239 +/- 0.062 ml/kg. Thus, only 21% of the total blood volume redistribution was attributable to active reflex responses. Deterioration of the preparation may have attenuated the magnitude of active reflex activity. Neither the systemic vascular compliance of 1.80 +/- 0.35 ml/mm Hg.kg nor the fraction of venous return from the superior vena cava of 26.5 +/- 4.6% was significantly changed by reflex blockade.(ABSTRACT TRUNCATED AT 250 WORDS)
Pharmaceutical Promotion and Physician Requests to Hospital Formularies
Authors: Paul H. Rubin
Journal: JAMA (1994)

<h3>To the Editor.</h3> —It is not surprising that Drs Chren and Landefeld<sup>1</sup>found that spending by pharmaceutical companies increased the sales of their products, in this case through addition of the products to formularies. After all, the purpose of promotion is to promote. However, the interpretation of these results is important. Some might interpret the findings as indicating that pharmaceutical companies unduly influence behavior of physicians through promotional expenditures. This interpretation should be resisted. Rather, the article documents the social benefit of information provision by pharmaceutical companies. The article indicates that all requests for addition of new drugs to the formulary were at the request of physicians, often after interactions with drug companies. Thirteen of the requests were for drugs that represented a major therapeutic advance over existing drugs, and 13 were for drugs with a modest therapeutic advantage. Thus, the study indicates that pharmaceutical promotion was responsible for
The ecological fallacy
Authors: P. Sedgwick
Journal: BMJ (2011)

Researchers explored the relation between morbidity from injury in children and socioeconomic deprivation. An ecological cross sectional study of 862 electoral wards in the Trent region of northern England was performed.1 For each electoral ward the researchers obtained rates of admission of children to hospital for all injuries between 1992 and 1997. All hospitals in the Trent region were included, and data were aggregated for each electoral ward, regardless of which hospital children were admitted to. The Townsend score associated with each electoral ward was obtained. This score assesses socioeconomic deprivation in families and includes measurement of employment status, overcrowding, car ownership, and owner occupation …
571. Development of a Quantitative Potency Assay for Quality Control Testing for pVGI.1(VEGF2), a Naked DNA Vector
Authors: Li-chun Huang, Qing Wang, Jiemin Zhou, Hsing-yi Jan, Yawen L. Chiang
Journal: Molecular Therapy (2005)

The plasmid pVGI.1(VEGF2) contains 5283 base pairs and encodes the full length cDNA of the VEGF-2 gene. Preclinical studies and earlier clinical trials demonstrated that injecting the pVGI.1(VEGF2) directly into muscles provided therapeutic angiogenic effects both in the heart (CAD) and in the limb (PAD). Presumably, the VEGF-2 protein expressed from pVGI.1(VEGF2) promotes angiogenesis in the injected tissues. In vitro, it has been shown that the purified VEGF-2 protein mediated proliferative and chemotactic responses in endothelial cells through the binding to the VEGF receptors VEGFR-2 (KDR) or VEGFR-3 (Flt-4).
Is calcitriol [1,25(OH)2D3] harmful to renal function?
Authors: S. G. Massry
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypothalamic-pituitary-adrenal axis in corticosteroid-resistant bronchial asthma.
Authors: S J Lane, B A Atkinson, R Swaminathan, T H Lee
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We have examined whether the lack of clinical response to corticosteroids seen in corticosteroid resistant (CR) bronchial asthma is reflected in abnormalities of endogenous cortisol secretion and in the sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis in CR subjects by using a modification of the standard dexamethasone suppression test (DST) in response to 0.25 and 1 mg oral dexamethasone. Five corticosteroid-sensitive (CS) and five CR asthmatic subjects were studied on two occasions 1 mo apart. In the first limb of the study subjects received 0.25 mg of oral dexamethasone, and in the second limb they received 1 mg. Urinary cortisol was measured by fluorimetry after extraction, and plasma cortisol and adrenocorticotropic hormone (ACTH) concentrations were estimated by enzyme-linked immunosorbent assay (ELISA) and immunoradiometric assays, respectively. On Day 1, a 24-h urine sample was collected for estimation of urinary free cortisol. On Day 2, a fasting blood sample was taken at 9:00 A.M. for estimation of plasma cortisol and ACTH. At 11:00 P.M., 0.25 mg (1 mg) of dexamethasone was taken orally by each subject. On Day 3, blood was taken at 9:00 A.M. and 3:00 P.M. for similar estimations. The levels of urinary free cortisol (nmol/24 h) and predose plasma ACTH (ng/L) and cortisol (nmol/L) were 199 +/- 42, 27.4 +/- 5.7, and 300 +/- 48 (mean +/- SEM), respectively, in the CS group, and 210 +/- 74, 23.4 +/- 6.7, and 263 +/- 32 (mean +/- SEM), respectively, in the CR group (p > 0.05 for all comparisons). Plasma ACTH and cortisol concentrations were not significantly suppressed in either group after 0.25 mg dexamethasone, but were equally suppressed in both groups to undetectable levels by 1 mg dexamethasone. We conclude that CR asthma is not reflected in an altered secretory rate of endogenous cortisol or in an altered sensitivity of the HPA axis to dexamethasone suppression.
ACCENT-Based Web Calculators to Predict Recurrence and Overall Survival in Stage III Colon Cancer
Authors: Lindsay A. Renfro, Axel Grothey, Yuan Xue, Leonard B. Saltz, Thierry André, Chris Twelves, Roberto Labianca, Carmen J. Allegra, Steven R. Alberts, Charles L. Loprinzi, Greg Yothers, Daniel J. Sargent
Journal: JNCI Journal of the National Cancer Institute (2014)

Current prognostic tools in colon cancer use relatively few patient characteristics. We constructed and validated clinical calculators for overall survival (OS) and time to recurrence (TTR) for stage III colon cancer and compared their performance against an existing tool (Numeracy) and American Joint Committee on Cancer (AJCC) version 7 staging. Data from 15936 stage III patients accrued to phase III clinical trials since 1989 were used to construct Cox models for TTR and OS. Variables included age, sex, race, body mass index, performance status, tumor grade, tumor stage, ratio of positive lymph nodes to nodes examined, number and location of primary tumors, and adjuvant treatment (fluoropyrimidine single agent or in combination). Missing data were imputed, and final models internally validated for optimism-corrected calibration and discrimination and compared with AJCC. External validation and comparisons against Numeracy were performed using stage III patients from NSABP trial C-08. All statistical tests were two-sided. All variables were statistically and clinically significant for OS prediction, while age and race did not predict TTR. No meaningful interactions existed. Models for OS and TTR were well calibrated and associated with C-indices of 0.66 and 0.65, respectively, compared with C-indices of 0.58 and 0.59 for AJCC. These tools, available online, better predicted patient outcomes than Numeracy, both overall and within patient subgroups, in external validation. The proposed ACCENT calculators are internally and externally valid, better discriminate patient risk than AJCC version 7 staging, and better predict patient outcomes than Numeracy. These tools have replaced Numeracy for online clinical use and will aid prognostication and patient/physician communication.
Guanine nucleotide-binding protein, alpha i-3, directly activates a cation channel in rat renal inner medullary collecting duct cells.
Authors: D B Light, D A Ausiello, B A Stanton
Journal: Journal of Clinical Investigation (1989)

We examined whether GTP binding proteins (G proteins) regulate sodium conducting channels in the apical membrane of renal inner medullary collecting duct (IMCD) cells and thereby modulate sodium absorption. Patch clamp studies were conducted on inside-out patches of the apical membrane of IMCD cells grown in primary culture. Guanosine 5'-triphosphate (GTP) and the nonhydrolyzable GTP analogue, GTP gamma S, which activate G proteins, increased the open probability of the cation channel. In contrast, the nonhydrolyzable GDP analogue, GDP beta S, which decreases G protein activity, inhibited the channel. Pertussis toxin also reduced the open probability of the channel. Addition of the alpha *i-3 subunit of Gi to the solution bathing the cytoplasmic surface of the membrane increased the open probability in a dose-dependent manner (2-200 pM). The threshold concentration for activation by alpha *i-3 was 2 pM. Activation of the cation channel by alpha *i-3 was not mediated via a protein kinase. The IMCD is the first polarized epithelium in which an ion channel has been shown to be directly regulated by a G protein. Thus, G proteins are important elements in regulating sodium absorption by the IMCD.
Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function
Authors: M. Pilar Gil, Mickaël J. Y. Ploquin, Wendy T. Watford, Seung-Hwan Lee, Kwangsin Kim, Xin Wang, Yuka Kanno, John J. O'Shea, Christine A. Biron
Journal: Blood (2012)
Intraaortic balloon counterpulsation with and without reperfusion for myocardial infarction shock.
Authors: M A DeWood, R N Notske, G R Hensley, J P Shields, W P O'Grady, J Spores, M Goldman, J H Ganji
Journal: Circulation (1980)

Forty patients were treated for cardiogenic shock secondary to acute myocardial infarction. Twenty-one (group 1) were treated with intraaortic balloon counterpulsation and 19 (group 2) were treated with counterpulsation and coronary artery bypass grafting. The groups were similar in age, incidence of previous infarction, initial hemodynamics and coronary anatomy. The in-hospital mortality between group 1 (52.4%) and group 2 (42.1%) was not significantly different. The difference in long-term mortality between group 1 and group 2 was substantially different (71.4% vs 47.3%). The subset of group 2 (n = 12) that underwent reperfusion and counterpulsation within 16 hours from the onset of symptoms of infarction had a lower mortality (25.0%) than the subset (n = 7) that underwent operation more than 18 hours after the onset of symptoms (71.4%). The long-term mortality in the subset of group 2 patients operated on within 16 hours after the onset of infarction was significantly different from that in group 1 (25.0% vs 71.4%, p less than 0.03). The data suggest that reperfusion with counterpulsation is more effective when carried out early. Patients who develop shock more than 18 hours after the onset of symptoms of infarction appear to benefit most if treated with counterpulsation alone.
Experience with radiofrequency ablation of hepatocellular carcinoma in patients awaiting liver transplantation
Authors: V. Mazzaferro, D. Sarli, S. Perrone, M. Schiavo, F. Garbagnati, A. Marchiano, T. Camerini, J. Coppa, R. Romito, A. Pulvirenti, E. Regalia, S. Andreola
Journal: Journal of Hepatology (2003)
ST-ELEVATION MYOCARDIAL INFARCTION IN THE MODERN ERA: HAVE WE REDUCED THE GENDER DISPARITY?
Authors: Sara DeReath Collins, Itsik Ben-Dor, Gabriel Maluenda, Manuel Gonzalez, Michael A. Gaglia, Asmir I. Syed, Kohei Wakabayashi, Rebecca Torguson, Zhenyi Xue, Adrian D. Margulies, Nicholas Hanna, Cedric Delhaye, Kenneth M. Kent, Nelson Bernardo, Augusto D. Pichard, William O. Suddath, Lowell F. Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2010)
The Other Side
Authors: Inginia Genao
Journal: Annals of Internal Medicine (2014)

On Being a Doctor16 September 2014The Other SideInginia Genao, MDInginia Genao, MDFrom Yale University School of Medicine, New Haven, Connecticut.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0437 Audio Reading - “The Other Side” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Other Side," by I. Genao. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Early one morning I got the news of my mother's admission to the hospital. My drive to see her was quiet and solemn. The trees were leaning forward with the weight of snow, almost forming an arch over some parts of the road. The scene was enchanting as well as terrifying, as I thought of my non–English-speaking mother, my pillar of strength, hunched over in pain and fear in a hospital room. I thought of how much she must need me now, her oldest daughter. Among her siblings, she is the only one in the United States.She immigrated to ... Author, Article, and Disclosure InformationAffiliations: From Yale University School of Medicine, New Haven, Connecticut.Corresponding Author: Inginia Genao, MD, 333 Cedar Street, New Haven, CT 06820; inginia.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “The Other Side” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Other Side," by I. Genao. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 16 September 2014Volume 161, Issue 6Page: 451-452KeywordsChildrenFoodForecastingHealth careHearingHospitalsNursesPatient advocacyPatientsSafety ePublished: 16 September 2014 Issue Published: 16 September 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Neural reuse as a source of developmental homology
Authors: David S. Moore, Chris Moore
Journal: Behavioral and Brain Sciences (2010)

Abstract Neural reuse theories should interest developmental psychologists because these theories can potentially illuminate the developmental relations among psychological characteristics observed across the lifespan. Characteristics that develop by exploiting pre-existing neural circuits can be thought of as developmental homologues. And, understood in this way, the homology concept that has proven valuable for evolutionary biologists can be used productively to study psychological/behavioral development.
An altered platelet granule glycoprotein in patients with essential thrombocythemia.
Authors: W J Booth, M C Berndt, P A Castaldi
Journal: Journal of Clinical Investigation (1984)

The protein profiles of washed platelets from nine patients with essential thrombocythemia were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In four patients, an additional protein band (reduced Mr of 170,000) was clearly identified in both unstimulated platelet preparations and thrombin-released supernatant fractions. This band was also evident, though to a lesser extent, in three more patients, but it could not be located in the two remaining patients nor in any of ten controls. Subsequent characterization of the 170,000 reduced protein in one patient indicated that (a) it was glycosylated, as judged by periodic acid-Schiff staining, and (b) that native protein was a disulfide-linked multimer (possibly trimeric), which (c) partially bound to the activated platelet plasma membrane in the presence of calcium, and (d) was immune precipitated by anti-glycoprotein G antisera. The combined evidence is consistent with the 170,000 reduced protein being a modified form of the normal subunit of the platelet alpha-granule constituent, glycoprotein G (also termed thrombospondin and thrombin-sensitive protein).