tbuckley/cabot-search huggingface dataset:
Myocardial Infarction in Treated Hypertensive Patients
Authors: Michael H. Alderman, Hillel W. Cohen, Shantha Madhavan
Journal: Circulation (2000)

Background —Despite the impressive decline in coronary heart disease death rates, a mortality differential between blacks and whites persists. Our study objective was to determine whether excess mortality among well-controlled hypertensive black men compared with whites is due to differences in disease incidence or in case fatality. Methods and Results —Of 3382 male subjects (1266 blacks and 2116 whites) enrolled between 1973 and 1996 and followed up through 1997 in a work-site hypertension control program, 2343 were followed up until 60 years of age, and 1884 were followed up until &gt;60 years of age (either continuing after 60 years [n=845] or beginning treatment at ≥60 years [n=1039]), with a mean follow-up of 5.2 and 5.5 years, respectively. During follow-up, 186 myocardial infarction (MI) events (including 31 revascularizations) occurred, with 63 in patients &lt;60 years and 123 in patients ≥60 years of age. Age-adjusted MI incidence was nearly twice as high for whites as blacks in younger (6.3 versus 3.4/1000 person-years) and older (14.1 versus 7.5 person-years) subjects. In contrast, the age-adjusted case fatality rate was 3-fold higher for younger blacks than for whites (37.8% versus 12.2%). In older patients, case fatality did not differ significantly between blacks and whites (37.6% versus 50.3%). In separate Cox regression analyses, among younger blacks but not younger whites, history of diabetes and smoking were significantly associated with both incidence and fatality. Conclusions —In these treated male hypertensive patients with good blood pressure control (139.6/85.7 mm Hg), young blacks, despite a lower MI incidence, had higher MI mortality than did their white counterparts. Their higher case fatality rate was associated with fewer coronary artery revascularizations and a higher prevalence of diabetes and smoking.
Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML
Authors: Amy Sexauer, Alexander Perl, Xiaochuan Yang, Michael Borowitz, Christopher Gocke, Trivikram Rajkhowa, Christian Thiede, Mark Frattini, Grant E. Nybakken, Keith Pratz, Judith Karp, B. Douglas Smith, Mark Levis
Journal: Blood (2012)
PTH-018 Towards Novel Non Invasive Methods to Diagnose Colorectal Cancer Using an Electronic Noses (E-Nose) And Field Asymmetric Ion Mobility Spectrometry (Faims)
Authors: J Covington, E Westinbrink, N O’Connell, C Bailey, S Smith, C Nwokolo, C Harmston, K Bardhan, R Arasaradnam
Journal: Gut (2013)

<h3>Introduction</h3> Using an electronic nose (E-nose) we have previously demonstrated its ability to detect inflammatory bowel disease (IBD) by shifts in the patterns of volatile organic compounds (VOCs) in the gases and vapours that emanate from urine samples. A similar distinction could be made using FAIMS, which involves a different principle, but still with gas phase samples. Here, we have extended our work to detect colon cancer from odours from urine alone. <h3>Methods</h3> Technology Principles: The E-nose uses an array of gas phase chemical sensors which are broadly tuned to different chemical groups (e.g. alcohols, gases). When a sample is presented to the sensor array, as each sensor is different, it will produce a unique response to that sample. By taking all of the sensor responses together, we can create a ‘bio-odorant fingerprint’ of that sample; thus mimicking the human olfactory system. FAIMS operates on similar principles, but produces its fingerprint by measuring the differences in mobility of ionised chemicals in high electric fields. 47 subjects were recruited; 20 with colonic adenocarcinoma (CRC) and 27 controls. The latter comprised 20 with ulcerative colitis (UC) in remission (defined as SCAI score &lt; 4) and 7 healthy subjects. 10 ml urine aliquots were collected and stored frozen. For assay, the containers were first heated to 60 ± 0.1oC. The headspace (the air above the sample) was analysed by an AlphaMOS FOX 4000 E-nose and by an Owlstone Lonestar FAIMS instrument. Discriminant Function Analysis and Fisher Discriminant Analysis were used for statistical evaluation, respectively. <h3>Results</h3> The E-nose (Figure 1) and FAIMS plots (not shown) shows those with CRC are tightly grouped and distinct from healthy controls and those with UC (p &lt; 0.001). <h3>Conclusion</h3> This pilot study suggests that both E-nose and FAIMS offer a different and non-invasive approach with high potential to identify those with CRC. <h3>Disclosure of Interest</h3> None Declared.
Obstetric Adversity and Age at First Presentation With Schizophrenia: Evidence of a Dose-Response Relationship
Authors: Brendan D. Kelly, Larkin Feeney, Eadbhard O’Callaghan, Roy Browne, Majella Byrne, Niamh Mulryan, Ann Scully, Mary Morris, Anthony Kinsella, Noriyoshi Takei, Thomas McNeil, Dermot Walsh, Conall Larkin
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: The purpose of the study was to determine if a dose-response relationship exists between obstetric adversity and age at first presentation with schizophrenia. METHOD: The Dublin Psychiatric Case Register was used to identify subjects with schizophrenia. Data on obstetric complications, social class of origin, and family history of psychiatric illness were obtained for those subjects. RESULTS: A total of 409 patients with ICD-9 schizophrenia were identified. Patients with a history of obstetric complications presented earlier to psychiatric services. As the number of complications increased, the mean age at first presentation decreased. This effect was independent of social class of origin and family history of psychiatric illness. CONCLUSIONS: Obstetric adversity exerts an independent influence on the age at first presentation with schizophrenia, in a dose-response manner. This finding supports the existence of a causal relationship between obstetric adversity and age at first presentation with schizophrenia.
Efficacy of Sonovue, a new second generation echocontrast agent, for the evaluation of microvascular perfusion after acute myocardial infarction by real-time perfusion imaging: comparison with SPECT
Authors: Luciano Agati, Stefania Funaro, Maria Pina Madonna, Daniela Bokor, Massimo Bona, Gabriele Veneroso, Francesca De Maio
Journal: Journal of the American College of Cardiology (2002)
Hypoxia-inducible gene expression system using the erythropoietin enhancer and 3′-untranslated region for the VEGF gene therapy
Authors: Minhyung Lee, Donghoon Choi, Min Ji Choi, Ji Hoon Jeong, Won Jong Kim, Seungjoon Oh, Yong-Hee Kim, David A. Bull, Sung Wan Kim
Journal: Journal of Controlled Release (2006)
Microalbuminuria in diabetes: Data dispersion: Author's reply
Authors: J Yip, H Vora, G C Viberti
Journal: BMJ (1993)

<h3>Abstract</h3> A growing body of evidence demonstrates visual, perceptual, and oculomotor abilities contribute to batting performance in baseball and there is interest in whether training such abilities can transfer positively to batting performance. The current study tested this question through a pre-registered randomized, and placebo-controlled intervention, conducted with 24 collegiate baseball players at two Division 1 universities. Athletes were randomized to receive either dynamic vision training consisting of stroboscopic, anticipatory timing, and eye quickness drills, or placebo drills stylized after control procedures in previous vision therapy studies. Generalized near-transfer was tested via a digital visual-motor task battery (<i>n</i> = 20), while sports-specific intermediate and far transfer of training were evaluated through instrumented batting practice metrics (<i>n</i> = 14) and box score performance in NCAA-sanctioned games (<i>n</i> = 12). The effects of training group were tested on these outcome measures while controlling for covariates such as pre-training expectations and site. Participants averaged 8.50 hours of training with no significant training group differences in adherence, expectations, or baseline assessments. ANCOVA revealed no group differences in measures of visual-motor skills or NCAA game statistics. However, batting practice demonstrated significant improvements in launch angle (<i>p</i> = 0.002, Cohen’s <i>d</i> = 0.74) and hit distance (<i>p</i> &lt; 0.001, Cohen’s <i>d</i> = 0.70) for the active cohort relative to the placebo control. This controlled and pre-registered pilot study therefore provides preliminary evidence that vision training may improve batting practice performance, creating new opportunities for the transfer of skill training and warranting further study. <h3>Pre-Registration</h3> At Open Science Framework on August 9, 2018. DOI 10.17605/OSF.IO/496RX. Accessible at https://osf.io/jxh8u
Diagnosis and Treatment of Cutaneous Anthrax
Authors: J. A. Holgate, R. A. Holman
Journal: BMJ (1949)

FACTORS A AND B RDITSJH 57L 5 370 C. for both A1 and A2 cells.Further, there was a prozone phenomenon in the test for A1 agglutination at 40 C. It was shown by a blocking test (Race, 1944 ; Wiener, 1944) that this prozone was due to the presence of an anti-A blocking antibody.Time o~f ClsTm.Serum Dilutions Test Cels Temp.1/1 | 1/21 1/22 1/28 1/24 1/25 1/28 1/27 1/28 1/29 T 1 , 37'C ++ + w Day of 4' C. 3* 3* 3* 2w2 1 ++++ _ _ - transfu-A, 37{ C. + + + w _ w sion A 40 C. 3 3 2 2 + ++++-A, 370 C. 2 2 1 + w 4th day 40 C. 4 4 4 3 3 2 1 + + + + _ A,t 37°C.++ ++ (+) ?? 3 2 40 C. 4 3* 3 3 1* + ( w -2 A, 37'C. 4 4 4 4 4 3 2 1 * + +-8th day 40 C. 4 4 4 4 3 2 2* l* + +(+)-A, U370 C. 4 4 3* 31 3 2* 1 * + + (+)-V40 C. 4 4 4 3* 3* 3 3 2 * + +-A, 370 C. 2* 4 3* 31 3* 31 3 2* 2 2 - 30th day ' 4'C.++ (+) + + + + 2 3* 3* 2 1 + + A, f370 C.2 2 3 2 3* 3 2* 2 2 1* - 40 C. 3* 3* 2* 3 3 3 2* 2 1 ++ - Scores for agglutination are given in arabic signs (for visual agglutination) and the signs usually employed for microscopical agglutination in Rh work (M.R.C.
Falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine.
Authors: A P Hall, E B Doberstyn, V Mettaprakong, P Sonkom
Journal: BMJ (1975)

Quinine (at least four doses given at intervals of eight to 12 hours) followed by a single dose of sulfadoxine-pyrimethamine (Fansidar) is the most effective treatment of chloroquine-resistant falciparum malaria. This regimen cured 96% of patients (302 out of 314) with an average initial parasite count of 90 X 10-9/1.
Report of the British Lying-In Hospital for 1883
Authors: H. Smith, F. Barnes
Journal: BMJ (1884)

THt SsAR ,O Jo r2 1t#: 9nd of hysterical conditions, on the secretion of t'ine, andthe pro-' bability bf a close connection between the different parts of the uri- nartr 1tack, we are inclined to suspect that A temporaxy derange- lent 'of the Action'of the kidney has soniething.to do with the.s-rlty of somp of these cases, even though such derangement is n6tr-evealed by post mortem examination.The effect produced on the kidneys would be dependent on two main factors-the magni-
The Treatment of Post Partum Haemorrhage by the Intra-Uterine Injection of Hot Water
Authors: W. Walter
Journal: BMJ (1880)

Cold applied by ice, or the application of iced-water into the uterus or the rectum, or by the sudden shock of a wet cloth to the vulva, was the remedy on which for many years I most relied in cases of flooding.But I now believe that, although of unquestionable utility in ordinary htemorrhagic discharge, or in violent floodings of short duration occurring in robust plethoric women, with a high bounding pulse, it is not suitable in the treatment of flooding in anaemic patients, and in such cases the undue continuance of cold injections may become an additional cauise of uterine inertia, and thus increase, instead of checking, the flooding.Hot fVater injections, in the circumstances just referred to, offer a rational, and, as Dr. Atthill has recently proved, effectual alternative treatment.Tyansfusion.-Thesuccess of transfusion, in a few cases of collapse from flooding, is hardly sufficient to warrant much dependence on it, save as a last resource.At some future time, this operation, in an im- proved form, is likely to fill a prominent place in medical and surgical, as well as in midwifery, practice; but, at present, its uncertainty, risks, and difficuilties are only equalled by the gravity of the conditiou in which its performance is justified.The promises held out when, upwards of half a century ago, Dr. Blundell revived transfusion, are apparently as far as ever from being realised.Nor have any of the more recent sug- gestions-such, for instance, as Dr. Aveling's direct arm-to-arm method, or Dr. R. MIcDonnell's operation with defibrinated blood, however superior in a physiological or theoretical aspect-afforded much better practical results than Dr. Blundell accomplished.Of six cases of transfusion, narrated in the Dublin Obstetrical Triansactions, within the last few years, three were successful, and in three the patients died.Cases of Tr-ans.fusion.Auth'-ority.Method Employed. Amounit of BloodResult.T'ransfused.
Formaldehyde-releasing biocides
Authors: K.D. Crow
Journal: British Journal of Dermatology (1982)

Journal Article Formaldehyde‐releasing biocides Get access K.D. Crow K.D. Crow Department of Dermatology, University Central Hospital, Snellmaninkatu 14, SF‐00170 Helsinki 17, Finland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 2, 1 February 1982, Page 251, https://doi.org/10.1111/j.1365-2133.1982.tb00939.x Published: 01 February 1982
Adoption, non-adoption, and abandonment of a personal electronic health record: case study of HealthSpace
Authors: T. Greenhalgh, S. Hinder, K. Stramer, T. Bratan, J. Russell
Journal: BMJ (2010)

<b>Objective</b> To evaluate the policy making process, implementation by NHS organisations, and patients’ and carers’ experiences of efforts to introduce an internet accessible personal electronic health record (HealthSpace) in a public sector healthcare system. <b>Design</b> Mixed method, multilevel case study. <b>Setting</b> English National Health Service; the basic HealthSpace technology (available throughout England) and the advanced version (available in a few localities where this option had been introduced) were considered. <b>Main outcome measures</b> National statistics on invitations sent, HealthSpace accounts created, and interviews and ethnographic observation of patients and carers. Data analysis was informed by a socio-technical approach which considered macro and micro influences on both adoption and non-adoption of innovations, and by the principles of critical discourse analysis. <b>Participants</b> 56 patients and carers (of whom 21 opened a basic HealthSpace account, 20 had diabetes but were not initially using HealthSpace, and 15 used advanced HealthSpace accounts to exchange messages with their general practitioner), 3000 pages of documents (policies, strategies, business plans, minutes of meetings, correspondence), observational field notes, and 160 interviews with policy makers, project managers, and clinical staff. <b>Results</b> Between 2007 and October 2010, 172 950 people opened a basic HealthSpace account. 2913 (0.13% of those invited) opened an advanced account, compared with 5-10% of the population anticipated in the original business case. Overall, patients perceived HealthSpace as neither useful nor easy to use and its functionality aligned poorly with their expectations and self management practices. Those who used email-style messaging were positive about its benefits, but enthusiasm beyond three early adopter clinicians was low, and fewer than 100 of 30 000 patients expressed interest. Policy makers’ hopes that “deploying” HealthSpace would lead to empowered patients, personalised care, lower NHS costs, better data quality, and improved health literacy were not realised over the three year evaluation period. <b>Conclusion</b> Unless personal electronic health records align closely with people’s attitudes, self management practices, identified information needs, and the wider care package (including organisational routines and incentive structures for clinicians), the risk that they will be abandoned or not adopted at all is substantial. Conceptualising such records dynamically (as components of a socio-technical network) rather than statically (as containers for data) and employing user centred design techniques might improve their chances of adoption and use. The findings raise questions about how eHealth programmes in England are developed and approved at policy level.
On Nursing Systems
Authors: J. E. Neale
Journal: BMJ (1880)

THE BRITISH AfEDTCAL 70URNAL.[Jan.I7, i88o.thinner, and refusing to graze."On further inquiry, I-found the amount of milk given was now but sufficient for household purposes, and that it creamed badly.Here, then, I thought, is the clue to this chronic typhoid condition.How, then, is this result to be arrived at ?First, the frecal matter from the water-closet drain is poured into an open stream; the water of the stream becomes mere sewage, and this contaminated water is the only drink the cow can get.So perverse were these good folks in their belief that it was impossible that the milk from their cow could be the cause of their illness, that I had the greatest difficulty in persuading them to refrain from drinking it.After they consented to send their cow away, and get their milk from a neighbour- ing farm, a tardy but permanent convalescence resulted.
Scintigraphic Demonstration of Splenosis
Authors: CHARLES A. STEWART, IVAN T. SAKIMURA, MICHAEL E. SIEGEL
Journal: Clinical Nuclear Medicine (1986)

A case of splenosis, or the autotransplantation of splenic tissue following trauma, was encountered unexpectedly on a routine liver scan performed in the workup of alcoholic liver disease. Confirmatory scintigraphic images using Tc-99m labeled, heat-damaged, autologous erythrocytes are presented with CT scans of the abdomen.
Clinical Aspects of Operable Heart Disease
Authors: Denton A. Cooley
Journal: JAMA (1969)

This text attempts to survey the field of cardiovascular surgery, summarizing the most significant developments of the past two decades. A correlation between clinical features and operative findings is well presented. Throughout the text the pathologic physiology is stressed in each case to corroborate the findings of diagnosis, natural history, and therapy. Among the 24 chapters, 20 are devoted to specific lesions, grouping aortic valvular lesions with left ventricular outflow tract abnormalities. The remaining four chapters are concerned with methods of diagnosis, extracorporeal circulation, preoperative and postoperative care, and heart transplantation. Because of the continuous expansion of the field of cardiovascular surgery, the text may be destined for rather early obsolescence as new techniques appear. For example, the treatment for persistent truncus arteriosus is discussed as being questionably surgical, whereas during the past year the operative correction of this anomaly has been successfully accomplished in a growing number of cases.
Long-term benefit of early thrombolytic therapy in patients with acute myocardial infarction: 5 year follow-up of a trial conducted by the Interuniversity Cardiology Institute of the Netherlands
Authors: Maarten L. Simoons, Jeroen Vos, Jan G.P. Tijssen, Frank Vermeer, Freek W.A. Verheugt, X. Hanno Krauss, Volkert Manger Cats
Journal: Journal of the American College of Cardiology (1989)
The Law and Medical Advances
Authors: WARREN E. BURGER
Journal: Annals of Internal Medicine (1967)

Article1 September 1967The Law and Medical AdvancesWARREN E. BURGER, LL.D.WARREN E. BURGER, LL.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-15 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Wright, in his opening statement, suggested that the pace of man's development of standards of ethics and law does not seem to keep abreast of science. I do not think that they can do so. We cannot compare rates of development in two such totally dissimilar and unrelated areas as science and ethics or law. What has been said thus far underscores my own feeling that a lawyer or a judge has very little to contribute to this kind of a discussion except observations that will seem essentially negative to you, or at least to many of you. Many...References1. STUMPF SE: Some moral dimensions of medicine. Ann. Intern. Med. 64: 460, 1966. LinkGoogle Scholar2. SCHREINER GE: Liability: use of investigational drugs. Food, Drug, and Cosmetic Law Journal, July 1963, p. 403. Google Scholar3. OPPENHEIMER JR: Where is science heading? Réalitiés: Science Today—Special Issue, September 1963. Google Scholar4. BOWEN CD: The Lion and the Throne: The Life and Times of Sir Edward Coke. Little, Brown and Co., Boston and Toronto, 1957. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WARREN E. BURGER, LL.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe unfinished legacy of liver transplantation: Emphasis on immunologyMultinational Drug Development and Clinical Research: A Bird's Eye View of Principles and Practice 1 September 1967Volume 67, Issue 3_Part_2Page: 15-18KeywordsEmotionsMedical law ePublished: 1 December 2008 Issue Published: 1 September 1967 PDF downloadLoading ...
Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23)
Authors: E A Coenen, C M Zwaan, J Stary, A Baruchel, V de Haas, R W Stam, D Reinhardt, G J L Kaspers, S T C J M Arentsen-Peters, C Meyer, R Marschalek, L L Nigro, M Dworzak, R Pieters, M M van den Heuvel-Eibrink
Journal: Leukemia (2014)
Cerebral Vascular Diseases
Authors: Nicholas A. Vick
Journal: JAMA (1971)

<h3>Cerebral Circulation and Stroke,</h3> by K. J. Zülch, 222 pp, 71 illus, $17.10, New York: Springer-Verlag, 1971. These two well-produced volumes contain a wealth of current information in the field of cerebrovascular disease. They show the methods by which medicine investigates and analyzes the causes of this important condition, and makes us realize how vigorous and myriad are the approaches currently used. Zülch's book contains an important but brief chapter on internal carotid artery stenosis and an interesting section in which the factors of hypertension, hypotension, and thrombosis and microembolism are considered and compared as probable causes of cerebral infarction. The latter chapters are written by some of the main proponents of these mechanisms. A brief but masterful chapter by Wiley reviews the possibility of surgical therapy and, as Zülch notes, Wiley's clear and personal summary does not differ profoundly from the results of the American cooperative studies. The latter