tbuckley/cabot-search huggingface dataset:
Correction: Reference in Article on Chronic Fatigue
Authors: Peter Manu
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 December 1988Correction: Reference in Article on Chronic FatiguePeter Manu, MDPeter Manu, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-12-997_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:I would like to correct reference 13 in my article (1) on the frequency of the chronic fatigue syndrome. In this reference, the name of the journal, the year of publication, and the page numbers should have beenJ Infect. 1985;10:211-22, notJ Infect Dis. 1958;10:212-27....Reference1. ManuLaneMatthews PTD. The frequency of the chronic fatigue syndrome in patients with symptoms of persistent fatigue. Ann Intern Med. 1988;109:554-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Peter Manu, MDAffiliations: University of Connecticut Health Center Farmington, CT 06032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1988Volume 109, Issue 12Page: 997-997KeywordsChronic fatigue syndromeFatigue ePublished: 1 December 2008 Issue Published: 15 December 1988 PDF downloadLoading ...
MODERN PROBLEMS OF METABOLISM.
Authors: CARL VON NOORDEN
Journal: JAMA (1905)

Your president has conferred on me a great honor in asking me to deliver one of the opening lectures of the. new Harvey Medical Society of this city. It is your aim that from this well-established center waves of scientific stimulation for research work may arise and reach not only the circles of the professional workers of this city, but even those of the whole country. At this moment, when a society, promoted under such favorable auspices, opens its career by a course of lectures, I think it is opportune, not only to recount the results of investigations already completed, but principally to consider those problems which still await solution. I am perfectly aware that in doing so I must renounce giving to my hearers the harmonious impression, which a well-worked scheme calls forth; for I am to touch manifold subjects and points of view which stand wide apart and
Adult trigger finger
Authors: J. Henton, A. Jain, C. Medhurst, S. Hettiaratchy
Journal: BMJ (2012)

A 62 year old diabetic woman complains of pain in the palm of her hand at the base of her ring finger, which is held in flexion. Extension is painful, produces an audible click, and often requires the assistance of the other hand. Trigger finger is caused by inflammation and constriction of the retinacular sheath through which the flexor tendons run as they pass from the palm of the hand into the finger. This causes irritation of the tendon, sometimes resulting in the formation of a nodule, which impinges on the pulley, causing pain and restricting movement. The retinacular sheath is composed of five annular “pulleys” which hold the tendon close to the bone and are integral to the biomechanics of finger flexion (figure⇓). The A1 pulley, at the level of the metacarpal head, is the first part of the sheath and is subject to the highest force. Consequently, triggering usually occurs at this level. Fig 1 Lateral view of a digit showing a simplified view the annular pulley system (A1-5), the flexor tendons with inflammatory nodule, and the passage of the needle for corticosteroid injection The cause is often multifactorial. Trigger finger is most common in the sixth decade, women, people with diabetes, and the dominant hand.1 ### History
Ultrastructural organisation of intraepithelial nerves in the human airway tract.
Authors: A Laitinen
Journal: Thorax (1985)

Intraepithelial nerves of human airway tract were studied by electron microscopy after conventional glutaraldehyde fixation. Specimens were obtained from five patients at three different airway levels--the trachea, the right upper lobe bronchus, and segmental bronchus. Intraepithelial axon profiles were located either near the basement membrane or close to the lumen but were rare in the intermediate area of the epithelium. Axon profiles close to the lumen were seen only in the central airways (levels 1 and 2), while profiles close to the basement membrane were seen in all three levels.
Updating Cost-Effectiveness — The Curious Resilience of the $50,000-per-QALY Threshold
Authors: Peter J. Neumann, Joshua T. Cohen, Milton C. Weinstein
Journal: New England Journal of Medicine (2014)

The ratio of $50,000 per quality-adjusted life-year (QALY) gained by using a given health care intervention has long served as a benchmark for the value of U.S. health care. But evidence suggests that it is too low and might best be thought of as an implied lower boundary.
Secular Trends in Preterm Birth
Authors: Michael S. Kramer, Robert Platt, Hong Yang, K. S. Joseph, Shi Wu Wen, Lucie Morin, Robert H. Usher
Journal: JAMA (1998)

Context.—Canada and the United States have reported a recent increase in the incidence of preterm birth, but the reasons for this increase are unknown.Objective.—To assess secular trends in preterm birth and its potential determinants.Design.—Hospital-based cohort study.Setting.—Canadian tertiary care university teaching hospital, 1978-1996.Participants.—A total of 65,574 nonreferred live births and stillbirths.Main Outcome Measures.—Changes in occurrence of preterm birth, before and after adjustment for changes in method of gestational age assessment, obstetric intervention, registration of births weighing less than 500 g, and sociodemographic, behavioral, and clinical determinants.Results.—A crude secular increase in preterm births was seen for births less than 37, 34, and 32 completed weeks using 3 alternative gestational age estimation methods. Based on an algorithm incorporating both menstrual and early ultrasound gestational age estimates, rates increased from 6.6% to 9.8% for births at less than 37 weeks' gestation, 1.7% to 2.3% at less than 34 weeks, and 1.0% to 1.2% at less than 32 weeks. Exclusion of births weighing less than 500 g and those with induction or preterm cesarean delivery without labor before each of the corresponding gestational age cutoffs eliminated the secular trends for births before 34 and 32 weeks and attenuated the trend for births before 37 weeks. Nearly half of the remaining trend for births before 37 weeks was accounted for by the increasing use of early ultrasound dating. The residual trend was eliminated after controlling for secular increases in unmarried status and the proportion of women aged 35 years or older. These factors, combined with a decrease in alcohol consumption and increases in histological chorioamnionitis and cocaine use, appear to have counteracted a reduction in preterm birth since the mid-1980s that otherwise would have been observed.Conclusions.—This hospital's increase in preterm births since 1978 parallels increases reported in population-based national studies from the United States and Canada. This trend appears largely attributable to the increasing use of early ultrasound dating, preterm induction and preterm cesarean delivery without labor, and changes in sociodemographic and behavioral factors.
Antibodies to Epstein–Barr-Virus Antigens before and after the Development of Burkitt's Lymphoma in a Patient Treated for Hodgkin's Disease
Authors: Ian Magrath, Werner Henle, Raphael Owor, Charles Olweny
Journal: New England Journal of Medicine (1975)

THE nearly universal association of Epstein–Barr virus (EBV) with African Burkitt's lymphoma has been established by serologic procedures,1 demonstration of viral DNA in tumor biopsies by nucleic acid hybridization technics2 3 4 5 and detection of EBV-determined antigens within tumor cells6 or on their membranes.7 The capacity of EBV to transform lymphocytes in vitro into permanently growing lymphoblastoid cells8 and to induce lymphoid neoplasms in several nonhuman primates9 , 10 clearly indicates that it has an oncogenic potential. Since EBV is a common virus and the cause of infectious mononucleosis,11 its putative role in the origin of Burkitt's lymphoma cannot be envisioned without introduction of . . .
Disturbed anal sphincter function following vaginal delivery.
Authors: J M Wynne, J L Myles, I Jones, R Sapsford, R E Young, A Hattam, S E Cantamessa
Journal: Gut (1996)

BACKGROUND: Recently interest in idiopathic (neurogenic) faecal incontinence has swung from denervation of the external anal sphincter to the internal sphincter. AIMS: To evaluate the effects of vaginal delivery on the internal sphincter. SUBJECTS: 1372 mothers were studied antenatally and 1202 were accepted into the study. METHODS: Sphincter pressures were measured antenatally, in the early postnatal period, and six to 10 weeks later in selected patients. RESULTS: 755 of 1202 subjects assessed antenatally were primiparous women and 447 multiparous women. Some 320 previous spontaneous vaginal deliveries (SVD) (mean 59 mm Hg) and 67 previous forceps deliveries (mean 58 mm Hg) had lower resting pressures than 755 primiparous women (mean 66 mm Hg) (p &lt; 0.01). A total of 493 subjects were reassessed postnatally. There were 372 SVDs, 47 vacuum extractions, 20 forceps, and 54 caesarean deliveries. All vaginal deliveries but not caesarean sections dropped their resting anal pressures from antenatal values (p &lt; 0.001). Some 227 first SVDs had a much greater fall than 145 subsequent SVDs. In 162 subjects who had undergone their first vaginal delivery and who were followed up there was some recovery but the resting pressures were still lowered at six to 10 weeks post partum. CONCLUSIONS: The first vaginal delivery causes a permanent lowering of resting anal pressures. The possible reasons for this are discussed.
Editorial independence at the <i>BMJ</i> : Incident at Sri Lankan medical journal may show the way
Authors: Murali Vallipuranathan
Journal: BMJ (2004)

EDITOR—Smith wrote about editorial independence at the BMJ .1 A parallel situation exists in Sri Lanka.

The Ceylon Medical Journal is a quarterly publication of the Sri Lanka Medical Association. The two editors of the journal are appointed by the council of the association every three years and they become ex officio members of the council. The journal is …
Abstract 3234: Covalent capture of protein binding partners using an azide-tagged, photo-reactive stapled alpha helical p53 peptide
Authors: Amanda L. Whiting, Joe J. Mitala, Kathryn M. Headley, Joe Reilly, Bethanie L. Morrison, Kevin A. Murray, Federico Bernal
Journal: Cancer Research (2014)

Abstract Mutations in the DNA binding region of tumor suppressor p53 render it transcriptionally inactive (dominant negative) but can also manifest in transcriptionally-independent gain-of-function (GOF) effects, possibly due to mutp53 interacting with other, as yet, unknown targets. Identification of these targets would help to elucidate the pathways and vulnerabilities involved in mutp53 GOF. Covalently linking a known handle to these unknown proteins is one method to aid in their isolation and identification. A hydrocarbon-stapled alpha helical peptide of the p53 transactivation domain (residues 14-29), SAH-p53-8, has been shown to strongly interact with known p53 targets that utilize this domain for binding (HDM2, Kd = 55 nM, HDMX, Kd = 2.3 nM). Substitution of a key interacting residue for the unnatural amino acid benzoylphenylalanine (Bpa) results in a stapled peptide that retains the biochemical properties of SAH-p53-8 (affinities of 38.1 nM and 58.3 nM, respectively) and can covalently capture known targets via photochemical reaction. The introduction of an azido group - a versatile, biochemically-inert capping group - to the N-terminus of this photo-reactive peptide allows for the attachment of various tags to the covalently bound protein(s) via a copper-catazlyzed azide alkyne cycloaddition. Tags include both fluorophores for visualization and affinity tags for protein isolation. This poster will cover the biochemical proof-of-principle of this protein isolation method and exploration into more complex cell lysate environments. Citation Format: Amanda L. Whiting, Joe J. Mitala, Kathryn M. Headley, Joe Reilly, Bethanie L. Morrison, Kevin A. Murray, Federico Bernal. Covalent capture of protein binding partners using an azide-tagged, photo-reactive stapled alpha helical p53 peptide. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3234. doi:10.1158/1538-7445.AM2014-3234
Localization of sequences regulating ancestral and acquired sites of esterase6 activity in Drosophila melanogaster
Authors: M. J. Healy, M. M. Dumancic, A. Cao, J. G. Oakeshott
Journal: Molecular Biology and Evolution (1996)

We have broadly defined the DNA regions regulating esterase6 activity in several life stages and tissue types of D. melanogaster using P-element-mediated transformation of constructs that contain the esterase6 coding region and deletions or substitutions in 5' or 3' flanking DNA. Hemolymph is a conserved ancestral site of EST6 activity in Drosophila and the primary sequences regulating its activity lie between -171 and -25 bp relative to the translation initiation site: deletion of these sequences decrease activity approximately 20-fold. Hemolymph activity is also modulated by four other DNA regions, three of which lie 5' and one of which lies 3' of the coding region. Of these, two have positive and two have negative effects, each of approximately twofold. Esterase6 activity is present also in two male reproductive tract tissues; the ejaculatory bulb, which is another ancestral activity site, and the ejaculatory duct, which is a recently acquired site within the melanogaster species subgroup. Activities in these tissues are at least in part independently regulated: activity in the ejaculatory bulb is conferred by sequences between -273 and -172 bp (threefold decrease when deleted), while activity in the ejaculatory duct is conferred by more distal sequences between -844 and -614 bp (fourfold decrease when deleted). The reproductive tract activity is further modulated by two additional DNA regions, one in 5' DNA (-613 to -284 bp; threefold decrease when deleted) and the other in 3' DNA (+1860 to +2731 bp; threefold decrease when deleted) that probably overlaps the adjacent esteraseP gene. Collating these data with previous studies suggests that expression of EST6 in the ancestral sites is mainly regulated by conserved proximal sequences while more variable distal sequences regulate expression in the acquired ejaculatory duct site.
The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis
Authors: Yuta Mishima, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Takaho A. Endo, Tetsuro Toyoda, Jun Shinga, Takuo Katsumoto, Tetsuhiro Chiba, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, Atsushi Iwama
Journal: Blood (2011)
621. Angiogenesis and Arteriogenesis in Ischemic Skeletal Muscles Following VEGF Gene Transfer by Adeno-Associated Virus Serotype 1 Vectors
Authors: Hua Yan, Xiaobing Wu, Lingyun Zu, Yanhong Guo, Peng Zhang, Wei Gao
Journal: Molecular Therapy (2005)

Top of pageAbstract
Recombinant adeno-associated viruses (rAAVs) have been widely explored for gene transfer into skeletal muscles. Serotype 2 rAAV (rAAV2) vectors have been most frequently employed. rAAV2 based vectors peudotyped with serotype 1 capsid proteins (rAAV1 vectors) may allow superior gene transfer into skeletal muscles. To assess the potential utility of rAAV1 vector gene transfer in ischemic skeletal muscles, we have generated rAAV1 vectors encoding green fluorescence protein (GFP) or LacZ as reporter gene or the 165 aa isoform of human vascular endothelial growth factor (VEGF165) as functional gene. In C2C12 derived myotubes the rAAV1-GFP vector allowed 3- to 4-fold higher gene expression in comparison with the rAAV2-GFP vector. VEGF secretion from C2C12 derived myotubes infected with rAAV1-VEGF165 vector increased significantly compared with that of rAAV2-165 vector. Following establishing ischemia in mouse hind limbs, high titer rAAV1 or rAAV2 vector preparations encoding LacZ were injected in ischemic thigh muscles. We demonstrated that the rAAV1-LacZ vector allowed higher level, broader distribution and longer lasting gene expression compared with the rAAV2-LacZ vector. At 6 months post rAAV vector injection substantial fraction of the muscle fibers were still expressing |[beta]|-gal in rAAV1-LacZ vector injected ischemic muscles, in contrast, |[beta]|-gal expression was barely detectable in rAAV2-LacZ vector injected ischemic muscles. Muscle VEGF165 production following the rAAV1-VEGF165 vector injection was 5 to 10 times higher than that following the rAAV2-VEGF165 vector injection. The average VEGF concentration was 205 |[plusmn]| 88 pg/mg total protein in the rAAV1-VEGF165 vector injected muscles compared with 38 |[plusmn]|22 pg/mg total protein in the rAAV2-VEGF165 injected muscles (P < 0.001, Fig. 1). High level VEGF165 production following the rAAV1-VEGF165 vector injection stimulated superior muscle regeneration, angiogenesis and arteriogenesis with the formation of relatively mature vascular structures in the previously ischemic skeletal muscles (Fig. 2). Thus, the rAAV1-VEGF165 vector mediated gene transfer can be a powerful tool for muscle ischemia treatment.
Early Detection of Melanoma
Authors: Martin A. Weinstock
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preimplantation Diagnosis for Fanconi Anemia Combined With HLA Matching
Authors: Yury Verlinsky
Journal: JAMA (2001)

The advent of single-cell polymerase chain reaction (PCR) has presented the opportunity for combined preimplantation genetic diagnosis (PGD) and HLA antigen testing. This is a novel and useful way to preselect a potential donor for an affected sibling requiring stem cell transplantation.To perform in vitro fertilization (IVF) and preimplantation HLA matching combined with PGD for Fanconi anemia (FA).DNA analysis for the IVS 4 + 4 A-->T (adenine to thymine) mutation in the FA complement C (FANCC) gene in single blastomeres, obtained by biopsy of embryos, to identify genetic status and HLA markers of each embryo before intrauterine transfer.In vitro fertilization programs at large medical centers in Chicago, Ill, and Denver, Colo.A couple, both carriers of the IVS 4 + 4 A-->T mutation in the FANCC gene with an affected child requiring an HLA-compatible donor for cord blood transplantation.DNA analysis of single blastomeres to preselect unaffected embryos representing an HLA match for the affected sibling.Of 30 embryos tested in 4 IVF attempts, 6 were homozygous affected and 24 were unaffected. Five of these embryos were also found to be HLA-compatible, of which 2 were transferred in the first and 1 in each of the other 3 cycles, resulting in a pregnancy and birth of an unaffected child in the last cycle.To our knowledge, this is the first PGD with HLA matching, demonstrating feasibility of preselecting unaffected embryos that can also be an HLA-compatible source for stem cell transplantation for a sibling.
Urethritis in Males Produced by Neisseria Gonorrhoeae From Asymptomatic Females
Authors: Leonard Brown
Journal: JAMA (1963)

ALTHOUGH GONORRHEA had been recognized clinically since antiquity, the etiological agent was not identified until 1879. By 1906, the gonococcus had been successfully cultured and differentially stained. With the advent of sulfonamides and penicillin, easy treatment became available for the cure of diagnosed cases. It soon became apparent, however, that the control of this disease would not be possible with therapeutic programs alone. During 1961, 265,665 cases of gonorrhea were reported in the US.<sup>1</sup>It was felt, however, that the reported number was about one tenth the actual incidence or more than 2,000,000 cases a year. Throughout the world, cases of gonorrhea have shown a steady increase, especially in teen-age groups. In almost every report, males outnumber females 3:1 in seeking medical attention for gonorrhea. With syphilis, however, statistics indicate that the prevalence is approximately the same in both sexes. Since both diseases are acquired in like manner, this