Influence of Dietary Sodium on Renal Function in Patients with Chronic Renal Disease
Authors: DANIEL M. LEVIN
Journal: Annals of Internal Medicine (1965)

Article1 February 1965Influence of Dietary Sodium on Renal Function in Patients with Chronic Renal DiseaseDANIEL M. LEVIN, M.D., ROBERT CADE, M.D.DANIEL M. LEVIN, M.D.Search for more papers by this author, ROBERT CADE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-231 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn describing the life-threatening syndrome of renal salt-wasting, Thorn, Koepf, and Clinton (1) and others (2, 3) stated that the condition is not due to a single typical pathologic lesion in the kidney. Rather, they said, it may occur in the course of any insidious but progressive renal disease. In fact, the clinical picture and laboratory finding of hyponatremia may be the first indication of previously unrecognized disease of the kidneys (2).Previous studies relating to the ability of patients with renal disease to conserve salt have yielded conflicting and inconclusive results. Cope (4) found that changes in dietary salt...References1. THORNKOEPFCLINTON GWGFJ: Renal failure simulating adrenocortical insufficiency. New Eng. J. Med. 231: 76, 1944. CrossrefGoogle Scholar2. SAWYERSOLEZ WHC: Salt-losing nephritis simulating adrenocortical insufficiency. New Eng. J. Med. 240: 210, 1949. CrossrefMedlineGoogle Scholar3. READ AE: Salt loss in chronic renal disease. Brit. Med. J. 1: 1399, 1956. CrossrefMedlineGoogle Scholar4. COPE CL: Studies of urea excretion. VII. The effects on the urea clearance of changes in protein and salt contents of the diet. J. Clin. Invest. 12: 567, 1933. CrossrefMedlineGoogle Scholar5. KEMPNER W: Compensation of renal metabolic dysfunction. N. Carolina Med. J. 6: 61, 117, 1945. Google Scholar6. MACGUIRE WB: Risk of uremia due to sodium depletion. JAMA 137: 1136, 1949. Google Scholar7. SOLOFFZATUCHNI LAJ: Syndrome of salt depletion. JAMA 139: 1136, 1949. CrossrefMedlineGoogle Scholar8. SCHROEDER H: Renal failure associated with low extracellular sodium chloride; the low salt syndrome. JAMA 141: 117, 1949. CrossrefMedlineGoogle Scholar9. WESTONHELLMANESCHEREDELMANGROSSMANLEITER RELDJISJL: Studies on the influence of the low sodium cardiac diet and the Kempner regimen on renal hemodynamics and electrolyte excretion in hypertensive subjects. J. Clin. Invest. 29: 639, 1950. CrossrefMedlineGoogle Scholar10. NICKELLOWRANCELEIFER JFPE: Effect of sodium depletion and repletion on renal function and body fluids during uremia. J. Clin. Invest. 30: 664, 1951. Google Scholar11. NICKELLOWRANCELEIFERBRADLEY JFPESE: Renal function, electrolyte excretion, and body fluids in patients with chronic renal insufficiency before and after sodium deprivation. J. Clin. Invest. 32: 68, 1953. CrossrefMedlineGoogle Scholar12. SCHREINER GE: Determination of inulin by means of resorcinol. Proc. Soc. Exp. Biol. Med. 74: 117, 1950. CrossrefMedlineGoogle Scholar13. SMITHFINKELSTEINALIMINOSACRAWFORDGRABER HWNLBM: The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man. J. Clin. Invest. 24: 388, 1945. CrossrefMedlineGoogle Scholar14. WALSERSELDINGROLLMAN MDWA: An evaluation of radiosulfate for the determination of the volume of extracellular fluid in man and dogs. J. Clin. Invest. 32: 299, 1953. CrossrefMedlineGoogle Scholar15. WIGGINSMANRYLYONSPITTS WSCHRHRF: The effect of salt-loading and salt depletion on renal function and electrolyte excretion in man. Circulation 3: 275, 1951. CrossrefMedlineGoogle Scholar16. BLACKPLATTSTANBURY DARSW: Regulation of sodium excretion in normal and salt-depleted subjects. Clin. Sci. 9: 205, 1950. MedlineGoogle Scholar17. PITTS RF: Physiology of the Kidney and Body Fluids, Year Book Medical Publishers, Inc., Chicago, 1963, p. 191. Google Scholar18. SMITH HW: The excretion of water. Bull. NY Acad. Med. 23: 177, 1947. Google Scholar19. BLAKE W: Sodium conservation and control of glomerular filtration rate. Amer. J. Physiol. 201: 149, 1961. CrossrefGoogle Scholar20. STEINLEVITTGOLDSTEINPORUSHEISNERLEVITT RMBHMHJGGMMF: The effects of salt restriction on the renal concentrating operation in normal hydropenic man. J. Clin. Invest. 41: 2101, 1962. CrossrefMedlineGoogle Scholar21. LANDISELSOMBOTTSHIELS EMKAPAE: Observations on sodium chloride restriction and urea clearance in renal insufficiency. J. Clin. Invest. 14: 525, 1935. CrossrefMedlineGoogle Scholar22. MERRILL JP: Nutrition in chronic renal failure. JAMA 173: 905, 1960. CrossrefGoogle Scholar23. CHASISGOLDRINGBREEDSCHREINERBOLOMEY HWESGEAA: Salt and protein restriction: effects on blood pressure and renal hemodynamics in hypertensive patients. JAMA 142: 711, 1950. CrossrefMedlineGoogle Scholar24. SARTORIUSROEMMELTPITTS OWJCRF: The renal regulation of acid-base balance in man. IV: The nature of the renal compensations in ammonium chloride acidosis. J. Clin. Invest. 28: 423, 1949. CrossrefGoogle Scholar25. PITTS RF: Physiology of the Kidney and Body Fluids, Year Book Medical Publishers, Inc., Chicago, 1963, p. 93. Google Scholar26. GOLDSMITHRECTORSELDIN CFCDW: Evidence for a direct effect of serum sodium concentration on sodium reabsorption. J. Clin. Invest. 41: 850, 1962. CrossrefMedlineGoogle Scholar27. GANNWRIGHT DSHK: Changes in proximal tubular reabsorption of sodium as a function of sodium intake in man. Clin. Res. 11: 241, 1963. Google Scholar28. BERLINERKENNEDYORLOFF RWTJJ: Factors affecting the transport of potassium and hydrogen ions by the renal tubules. Arch. Int. Pharmacodyn. 97: 299, 1954. MedlineGoogle Scholar29. CADESHALHOUBCANESSA-FISCHERPITTS RRJMRF: Effect of strophanthidin on the renal tubules of dogs. Amer. J. Physiol. 200: 373, 1961. CrossrefMedlineGoogle Scholar30. WELT LG: Clinical Disorders of Hydration and Acid-Base Equilibrium, Little, Brown and Co., Boston, 1959, p. 139. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Gainesville, FloridaFrom the Department of Medicine, University of Florida, College of Medicine, Gainesville, Fla.This work was supported by grants 2A-5172 from the National Institute of Arthritis and Metabolic Diseases, GM-K3-8792 from the Career Development Review Branch, and AM-05712-01A2 from the National Institute of General Medical Sciences, U. S. Public Health Service, Bethesda, Md., and from the Florida Heart Association.Requests for reprints should be addressed to Daniel M. Levin, M.D., Department of Medicine, University of Florida, College of Medicine, Gainesville, Fla. 32603. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal InsufficiencyHepatorenal syndrome. Studies of the effect of vascular volume and intraperitoneal pressure on renal and hepatic functionIntra- and Interindividual Variability in Sodium Intake in Normal Subjects and in Patients With Renal InsufficiencyMedical Treatment of Renal HypertensionThe efficacy of quantitative and qualitative chloride titrators in the estimation of human salt intakeThe Management of Renal InsufficiencyRenal Physiology and Pathophysiology of Renal FailureSodium intake and furosemide administration in hypertensive patients with renal insufficiencyRelationships of the renin-angiotensin-aldosterone system and sodium balance to blood pressure regulation in chronic renal failure of polycystic kidney diseaseManagement of Chronic renal failureUrea metabolism in patients with chronic renal failure: Influence of sodium bicarbonate or sodium chloride administrationConservative Management of Chronic Renal FailureDie fr�hdistale Natriumkonzentration in Rattennieren nach renaler Isch�mie und h�morrhagischer HypotensionMetabolic Effects of Dietary Protein in Chronic Renal FailureDANIEL M. LEVIN, M.D., ROBERT CADE, M.D. 1 February 1965Volume 62, Issue 2Page: 231-245KeywordsBlood plasmaExcretionIngestionMedical servicesMetabolic disordersPyelonephritisRenal diseasesResearch laboratoriesSaltsSodium ePublished: 1 December 2008 Issue Published: 1 February 1965 PDF downloadLoading ...