tbuckley/cabot-search huggingface dataset:
Smoking Out the Barons: The Campaign Against the Tobacco Industry
Authors: Ronald M. Davis
Journal: JAMA (1987)

<i>Smoking Out the Barons</i>describes the recent antismoking campaign in the United Kingdom, the major goal of which is to ban all tobacco advertising or, as an interim measure, at least to prohibit tobacco sponsorship of sporting events. The book includes an inside look at the evolution of the campaign, "lessons for campaigners," and important studies on the effects of cigarette advertising. The book contains five sections: (1) a narrative account of the British Medical Association's (BMA's) campaign against the tobacco industry, launched in October 1984; (2) a previously published treatise by Simon Chapman on the effects of cigarette advertising; (3) a chapter on cigarette advertising policy and on coverage of smoking and health in women's magazines; (4) a report on investments in the United Kingdom's tobacco industry, including those by health, religious, and charity organizations; and (5) a previously published study of the effects of cigarette sponsorship of televised
1131. Generation of Whole Cell Vaccines for Acute Myeloid Leukaemia by Lentivirus Mediated IL-2/CD80 Transduction
Authors: Lucas Chan, Nicola Hardwich, Dave Darling, Joop Gäken, Joanna Galea-Lauri, Steve Devereux, Ghulam Mufti, Farzin Farzaneh
Journal: Molecular Therapy (2005)

Despite recent treatment advances, the prognosis for the majority of AML patients remains bleak, particularly in the elderly, those with poor prognostic cytogenetics, and/or progression from myelodysplasia. We and others have previously shown that tumour cells engineered to express CD80 and IL-2 can stimulate T and NK cell responses against the unmodified tumour cells, and that vaccination with irradiated CD80/IL-2 expressing leukaemic cells can prolong survival in mouse models of leukaemia. In order to test the therapeutic potential of this approach, we have devised an efficient gene transfer protocol for primary human acute myeloid leukaemia blasts. Based on a previously established methodology for retroviral vectors, we show that disabled SIN-lentiviral vectors can be conjugated to streptavidin paramagnetic microparticles (PMP) after covalent linkage of biotin to 293T packaging cells. Biotin coated lentivirus is then captured and magnetically concentrated, resulting in up to 2600 fold titre enhancements after 100 fold volume reductions to achieve titres in excess of 109 cfu/ml for amphotropic or VSV-G pseudotypes. A self-inactivating lentiviral backbone, incorporating the HIV flap region and a myeloid efficient internal promoter, derived from spleen focus forming virus (SFFV), is used for the efficient co-expression of CD80 and IL-2 in primary AML blasts. These vectors express CD80 and IL-2 as a single fusion protein that incorporates the recognition sequence for a golgi/ER located ubiquitous endoprotease |[ndash]| furin between the CD80 and IL-2 moieties. This fusion protein is post-synthetically cleaved by furin to generate biologically active membrane anchored CD80 and secreted IL-2. Following a single round of infection of primary or established AML cells at an MOI of 10, between 40%-99% of AML blasts express CD80 and secrete 2-15 ng of IL-2/106/24hrs. The combined expression of IL-2 and CD80 enables the increased in vitro stimulation of allogeneic and autologous T cells obtained from AML patients, either before or following the induction of remission, with or without preceding bone marrow transplantation. The stimulated lymphocytes have a TH1 cytokine secretion profile and show evidence of specificity, as indicated by their increased proliferation in the presence of unmodified AML compared to remission bone marrow cells. The stimulated T cells also demonstrate cytotoxic activity against AML blasts. This data supports the notion that IL-2/CD80 whole cell vaccination could stimulate therapeutically useful immune responses in AML patients, particularly following chemotherapy induced remission and allogeneic bone marrow transplantation. We have recently been granted permission for the vaccination of poor prognosis AML patients with lentivirus mediated ex vivo transduced AML blasts expressing CD80 and IL-2.
Brahe, looking for Kepler
Authors: Shimon Edelman
Journal: Behavioral and Brain Sciences (2000)

Arbib, Érdi, and Szentágothai's book should be a required reading for any serious student of the brain. The scope and the accessibility of its presentation of the neurobiological data (especially the functional anatomy of select parts of the central nervous system) more than make up for the peculiarities of the theoretical stance it adopts.
Does HIV status influence the outcome of patients admitted to a surgical intensive care unit? A prospective double blind study
Authors: S. Bhagwanjee, D. J J Muckart, P. M Jeena, P. Moodley
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objectives:</b> (<i>a</i>) To assess the impact of HIV status (HIV negative, HIV positive, AIDS) on the outcome of patients admitted to intensive care units for diseases unrelated to HIV; (<i>b</i>) to decide whether a positive test result for HIV should be a criterion for excluding patients from intensive care for diseases unrelated to HIV. <b>Design:</b> A prospective double blind study of all admissions over six months. HIV status was determined in all patients by enzyme linked immunosorbent assay (ELISA), immunofluorescence assay, western blotting, and flow cytometry. The ethics committee considered the clinical implications of the study important enough to waive patients9 right to informed consent. Staff and patients were blinded to HIV results. On discharge patients could be advised of their HIV status if they wished. <b>Setting:</b> A 16 bed surgical intensive care unit. <b>Subjects:</b> All 267 men and 135 women admitted to the unit during the study period. <b>Interventions:</b> None. <b>Main outcome measures:</b> APACHE II score (acute physiological, age, and chronic health evaluation), organ failure, septic shock, durations of intensive care unit and hospital stay, and intensive care unit and hospital mortality. <b>Results:</b> No patient had AIDS. 52 patients were tested positive for HIV and 350 patients were tested negative. The two groups were similar in sex distribution but differed significantly in age, incidence of organ failure (37 (71%) <i>v</i> 171 (49%) patients), and incidence of septic shock (20 (38%) <i>v</i> 54 (15%)). After adjustment for age there were no differences in intensive care unit or hospital mortality or in the durations of stay in the intensive care unit or hospital. <b>Conclusions:</b> Morbidity was higher in HIV positive patients but there was no difference in mortality. In this patient population a positive HIV test result should not be a criterion for excluding a patient from intensive care. <h3>Key messages</h3> HIV positive patients admitted to intensive care for diseases unrelated to their HIV status have a similar mortality and duration of stay when compared with HIV seronegative patients The incidence of septic shock and multiple organ dysfunction is higher in HIV seropositive patients and needs further investigation HIV status cannot be used to deny critically ill patients admission to intensive care The HIV and AIDS epidemic raises unique ethical considerations that must be carefully addressed during clinical studies
Selecting is not abstracting
Authors: Stellan Ohlsson
Journal: Behavioral and Brain Sciences (1999)

Barsalou's hypothesis that mental representations are constructed by selecting parts of percepts encounters the same difficulties as other empiricist theories: They cannot explain concepts for which instances do not share perceptible features (e.g., furniture ) or for which there are no relevant percepts (e.g., the end of time ). Barsalou's attempt to reduce falsity to failed pattern matching is an elementary error, and the generativity of his simulators cannot be attained without nonterminal symbols. There is not now, and there never was, any reason to be interested in empiricist theories of knowledge. Abstraction is a fundamental aspect of human cognition.
Pathology of the Cardiac Conduction System in Hemochromotosis.
Authors: Thomas N. James
Journal: Annals of Internal Medicine (1964)

s1 February 1964Pathology of the Cardiac Conduction System in Hemochromotosis.Thomas N. James, M.D., F.A.C.P.Thomas N. James, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-317_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCardiac involvement by hemochromatosis is one of the well-known manifestations of this disease, and atrial arrhythmias and heart block are commonly observed. This is a report of the pathology of the cardiac conduction system in four patients with hemochromatosis who developed atrial arrhythmias or heart block.The blood supply to the sinus node and atrioventricular (A-V) node was carefully dissected in each case. Subserial sections of both nodes were prepared for microscopic study with the Goloner trichrome stain and Gomori's iron reaction.In all four hearts the fibers of the A-V node contained large amounts of iron and exhibited focal... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 317-318KeywordsArrhythmiaBloodCardiovascular therapyHeartHeart diseasesHemochromatosis Issue Published: 1 February 1964 PDF DownloadLoading ...
BMA chairman calls for end to market in health care
Authors: A. Cole
Journal: BMJ (2009)

The chairman of the BMA council, Hamish Meldrum, called on England’s new health secretary, Andy Burnham, to end once and for all the “waste and inefficiency” of the private finance initiative (PFI) and the “experiment” of a market in health care.

A recent analysis by the University of East Anglia indicated that the government could save £2.4bn (€2.8bn; $4bn) if it bought out all the private finance contracts in the NHS.

Dr Meldrum said, “Yet what do …
MENTAL EVOLUTION IN MAN.
Authors: R. M. BUCKE
Journal: JAMA (1897)

About sixty years ago, in the time of the Millerite excitement, a man who believed that the world was about to end expressed his fears to Emerson, who replied that it was really a matter of little consequence, "for," said he, "we can do very well without it." There are wise men who teach that each man creates the world he lives in, and as he gives it its substance so also does he give it its quality, insomuch that it is good or bad as he is good or bad. Be this as it may, it is certain that each one of us is of more consequence to himself than is all the outside world. Not only so, but the essential part of each man is what we call his mind, in comparison to which the body is an insignificant factor. <h3>The study of psychology.</h3> —Psychology ought to be
Early Nutrition in Critically Ill Patients
Authors: Juan B. Ochoa Gautier, Flávia R. Machado
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tyrosine kinase inhibitors for the treatment of fibrotic diseases such as systemic sclerosis: towards molecular targeted therapies
Authors: J H W Distler, O Distler
Journal: Annals of the Rheumatic Diseases (2009)

Systemic sclerosis (SSc) is a fibrosing connective tissue disease with significantly increased mortality. Therapeutic options to treat fibrosis are limited. The small molecule tyrosine kinase inhibitor imatinib and related drugs such as dasatinib and nilotinib target simultaneously two of the major profibrotic pathways, TGFβ- and PDGF- signaling. Imatinib, dasatinib and nilotinib inhibit collagen synthesis in cultured fibroblasts and have potent anti-fibrotic effects in animal models of different fibrotic diseases. Moreover, several case reports, case series and uncontrolled studies on patients with SSc, mixed connective tissue disease, nephrogenic systemic fibrosis and in particular sclerodermatous graft versus host disease (cGvHD) report regression of fibrosis and good tolerability. However, the results of larger controlled trials, which are currently ongoing, are needed before any conclusions on efficacy and tolerability can be drawn. Until the results of these trials are available, we discourage off-label use of Imatinib in single patients.
Controls in Cancer Chemotherapy
Authors: B. J. Kennedy, Athanasios Theologides
Journal: Annals of Internal Medicine (1972)

Editorials1 February 1972Controls in Cancer ChemotherapyB. J. KENNEDY, MD., F.A.C.P., ATHANASIOS THEOLOGIDES, M.D., PH.D., F.A.C.P.B. J. KENNEDY, MD., F.A.C.P.Search for more papers by this author, ATHANASIOS THEOLOGIDES, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-2-321 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe combination of several drug agents for the treatment of malignant diseases represents a new era in the chemotherapy of cancer and emphasizes that cure of some neoplastic diseases is a potentially attainable goal. In Hodgkin's disease, lymphoma, acute leukemia, and breast cancer, combination drug therapy has made possible a higher rate of regression (tumor shrinkage) and, more important, a higher rate of complete remission (disappearance of measurable tumor). As a result, combination chemotherapy is being endorsed by clinicians. This mode of therapy has been accepted, however, for many malignant neoplasms without adequately controlled studies.Historically, the first phase of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Minnesota School of Medicine Minneapolis, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCombination versus successive single agent chemotherapy in lymphocytic lymphoma 1 February 1972Volume 76, Issue 2Page: 321-322KeywordsBreast cancerCancer chemotherapyCancer treatmentChemotherapyCombination chemotherapyDrug regulationDrug therapyDrugsHodgkin lymphomaPrecursor cells Issue Published: 1 February 1972 PDF DownloadLoading ...
Abstract 1880: Role of fatty acid synthase and do novo lipogenesis in liver cancer development in mice.
Authors: Xin Chen, Lei Li, Chunmei Wang, Matthias Evert, Diego F. Calvisi, Clay F. Semenkovich
Journal: Cancer Research (2013)

Abstract Aberrant metabolism, including increased de novo lipogenesis, is one of the hallmarks of cancer. Fatty Acid Synthase (Fasn) catalyzes the de novo synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. Increased Fasn expression has been reported in multiple tumor types, and inhibition of Fasn expression has been shown to have tumor-suppressing activity. However, how increased de novo lipogenesis contributes to tumor initiation and progression, especially in vivo, remains unknown. In our previous studies, we showed that overexpression of the activated form of AKT (myr-AKT) induced de novo lipogenesis, hepatocyte proliferation and, eventually, liver cancer formation in mice. The tumorigenesis process could be significantly accelerated via co-expression of activated form of Ras. In the AKTRas tumor model, tumors were predominantly (&amp;gt;80%) hepatocellular carcinoma (HCC), and the remaining (&amp;lt;20%) were intrahepatic cholangiocarcinoma (ICC). The ICCs were induced via hepatocyte-biliary epithelial cell metaplasia in a Notch dependent manner. Intriguingly, fat droplet formation, increased expression of Fasn and other lipogenesis pathway genes were identified in HCC lesions, but not ICC lesions. To define whether Fasn-mediated de novo lipogenesis is a key metabolic event downstream of mTORC1 during AKTRas-induced hepatocarcinogenesis, we utilized Fasn flox/flox mice, and co-expressed AKTRas in the Fasn KO hepatocytes. Of note, we found that ablation of Fasn completely inhibited AKT induced lipogenesis and hepatocyte proliferation in mice. However, loss of Fasn modestly delayed AKTRas-induced liver tumor development. Histological analysis revealed that these tumor lesions were predominantly ICCs. The ICC cells were highly proliferative, and did not express Fasn or any other lipogenic pathway gene. The results suggest that Fasn-mediated de novo lipogenesis is required for AKTRas-induced HCC formation, but this process is dispensable for ICC formation. In summary, our experiments support a critical role for Fasn as a downstream effector of mTORC1 in HCC pathogenesis. However, Fasn-mediated do novo fatty acid synthesis is not required in all tumor types. It is likely that other sources of fatty acids, presumably including those derived from the diet, can be utilized by cancer cells for membrane synthesis during cell proliferation. Citation Format: Xin Chen, Lei Li, Chunmei Wang, Matthias Evert, Diego F. Calvisi, Clay F. Semenkovich. Role of fatty acid synthase and do novo lipogenesis in liver cancer development in mice. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1880. doi:10.1158/1538-7445.AM2013-1880 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Relation between plasma soluble intercellular adhesion molecule-1 level and the severity and the mortality of patients with congestive heart failure
Authors: Takayoshi Tsutamoto, Tomoko Hisanaga, Keiku Maeda, Yukiharu Moeda, Atsuyuki Wada, Daisuke Fukai, Masato Ohnishi, Masahiko Kinoshita
Journal: Journal of the American College of Cardiology (1996)
Individual psychology, market scaffolding, and behavioral tests
Authors: Daniel John Zizzo
Journal: Behavioral and Brain Sciences (2001)

Hertwig and Ortmann (H&amp;O) rightly criticize the usage of deception. However, stationary replication may often have no ecological validity. Many economic experiments are not interactive; when they are, there is not much specifically validating H&amp;O's psychological views on script enactment. Incentives in specific market structures may scaffold even zero rational decision-making, but this says very little about individual psychology.
Administration of anti-interleukin 18 antibody fails to inhibit development of dermatitis in atopic dermatitis-model mice NC/Nga
Authors: S. Higa, M. Kotani, M. Matsumoto, A. Fujita, T. Hirano, M. Suemura, I. Kawase, T. Tanaka
Journal: British Journal of Dermatology (2003)

Journal Article Administration of anti‐interleukin 18 antibody fails to inhibit development of dermatitis in atopic dermatitis‐model mice NC/Nga Get access S. Higa, S. Higa Department III of Internal Medicine, Osaka University Medical School, 2‐2 Yamada‐oka, Suita City, Osaka 565‐0871, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Kotani, M. Kotani Research and Development Center, Sunstar Incorporation, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Matsumoto, M. Matsumoto Research and Development Center, Sunstar Incorporation, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Fujita, A. Fujita Research and Development Center, Sunstar Incorporation, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hirano, T. Hirano Department III of Internal Medicine, Osaka University Medical School, 2‐2 Yamada‐oka, Suita City, Osaka 565‐0871, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Suemura, M. Suemura Nissay Hospital, Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar I. Kawase, I. Kawase Department III of Internal Medicine, Osaka University Medical School, 2‐2 Yamada‐oka, Suita City, Osaka 565‐0871, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Tanaka T. Tanaka Department III of Internal Medicine, Osaka University Medical School, 2‐2 Yamada‐oka, Suita City, Osaka 565‐0871, Japan Toshio Tanaka. E‐mail: ttanak@imed3.med.osaka‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 1, 1 July 2003, Pages 39–45, https://doi.org/10.1046/j.1365-2133.2003.05406.x Published: 01 July 2003 Article history Accepted: 28 November 2002 Published: 01 July 2003
Rules and fallacies
Authors: T. Dalrymple
Journal: BMJ (2011)

There has long been a controversy over how the name M’Naghten, of the so called M’Naghten Rules, or criteria for legal insanity, should be spelt. Richard Moran, in his 1981 book on the case, Knowing Right from Wrong, says that there are 12 known spellings; he plumps for McNaughtan.

This, of course, is not the only controversy surrounding it. M’Naghten shot Edward Drummond, Sir Robert Peel’s private secretary, in 1843, mistaking him for the prime minister himself. (Oddly enough, Professor Moran adds to the confusion by being unable to decide whether the victim was called Edward or Edmund Drummond.) M’Naghten believed that he was being persecuted by the government and the Tory party and was found not guilty by reason …
Randomized trial of lamivudine versus hepatitis B immunoglobulin for long-term prophylaxis of hepatitis B recurrence after liver transplantation
Authors: Nikolai V Naoumov, A.Ross Lopes, Patrizia Burra, Lucio Caccamo, Rosa M Iemmolo, Robert A de Man, Margaret Bassendine, John G O'Grady, Bernard C Portmann, Gaya Anschuetz, Catherine A Barrett, Roger Williams, Mark Atkins
Journal: Journal of Hepatology (2001)
Bioimaging and pulmonary applications of self-assembled Flt1 peptide–hyaluronic acid conjugate nanoparticles
Authors: Hyemin Kim, Hyun Taek Park, You Me Tae, Won Ho Kong, Dong Kyung Sung, Byung Woo Hwang, Ki Su Kim, Yoon Keun Kim, Sei Kwang Hahn
Journal: Biomaterials (2013)