Ringed Sideroblasts and Intramitochondrial Iron in Cases of Mechanical Hemolytic Anemia
Authors: LAWRENCE D. PETZ
Journal: Annals of Internal Medicine (1966)

Case Studies1 March 1966Ringed Sideroblasts and Intramitochondrial Iron in Cases of Mechanical Hemolytic AnemiaSignificance of These Findings and Observations on the Etiology of HemolysisLAWRENCE D. PETZ, M.D., JOSEPH R. GOODMAN, PH.D.LAWRENCE D. PETZ, M.D., JOSEPH R. GOODMAN, PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-635 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemolytic anemia on a mechanical basis has been well documented as an unusual complication of the use of prosthetic cardiovascular materials (1-12). The characteristic features of mechanical hemolytic anemia are the presence of numerous irregularly contracted erythrocytes in the blood film associated with signs of intravascular hemolysis (absent serum haptoglobin, elevated plasma hemoglobin, hemoglobinuria, and hemosiderinuria). However, the question still remains as to why some patients with artificial cardiovascular prostheses have clinically significant hemolysis whereas a majority do not (1, 2).The purposes of this paper are: [1] to report two patients who developed hemolytic anemia after insertion of the...References1. MARSH GW: Intravascular haemolytic anaemia after aortic-valve replacement. Lancet 2: 986, 1964. CrossrefMedlineGoogle Scholar2. YEHELLISONWRIGHT TJRGC: Hemolytic anemia due to a ruptured prosthetic aortic cusp. J. Thorac. Cardiov. Surg. 49: 963, 1965. CrossrefMedlineGoogle Scholar3. STOHLMANSARNOFFCASENESS FSJRBAT: Hemolytic syndrome following the insertion of a lucite ball valve prosthesis into the cardiovascular system. Circulation 13: 586, 1956. CrossrefMedlineGoogle Scholar4. SAYEDDACIEHANDLEYLEWISCLELAND HMJVDASMWP: Haemolytic anaemia of mechanical origin after open heart surgery. Thorax 16: 356, 1961. CrossrefMedlineGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: San Francisco, CaliforniaFrom the Department of Research, Veterans Administration Hospital, San Francisco, Calif.Requests for reprints should be addressed to Lawrence D. Petz, M.D., Clinical Investigator, Veterans Administration Hospital, 42nd Ave. and Clement St., San Francisco, Calif. 94121. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmune Hemolysis Associated with TransplantationErythropoeseREFERENCESReversible Megaloblastic and Sideroblastic Marrow Abnormalities in Alcoholic PatientsHemolytic Anemia Due to Progressive Enlargement of Silastic Ball Component of Aortic ProsthesisLangzeitbeobachtungen nach künstlichem Ersatz der Aorten- bzw. Mitralklappe unter besonderer Berücksichtigung von Klappeninsuffizienzen, Thrombembolien, Endokarditiden und BallveränderungenAccumulation of Iron in Mitochondria of ErythroblastsMicroangiopathic Hemolytic Anemia in Carcinoma of the StomachSevere Mechanical Hemolytic Anemia Due to Valvular Heart Disease Without ProsthesisSAUL ZIPEROVICH, M.D., H. W. PALEY, M.D.Renal Siderosis Morphology, Etiology, Pathogenesis and Differential Diagnosis 1 March 1966Volume 64, Issue 3Page: 635-643KeywordsAnemiaBlood plasmaElectron microscopyHaptoglobinsHematology and oncologyHemodynamicsHemoglobinHemolytic anemia Issue Published: 1 March 1966 PDF DownloadLoading ...