Endogenous Digoxin-like Substance(s) and Combined Hepatic and Renal Failure
Authors: M. Henry Gault, Sudesh C. Vasdev, Linda L. Longerich
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 October 1984Endogenous Digoxin-like Substance(s) and Combined Hepatic and Renal FailureM. HENRY GAULT, M.D., SUDESH C. VASDEV, PH.D., LINDA L. LONGERICH, M.SC.M. HENRY GAULT, M.D.Search for more papers by this author, SUDESH C. VASDEV, PH.D.Search for more papers by this author, LINDA L. LONGERICH, M.SC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-567_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: An endogenous digoxin-like substance has recently been described in the blood of neonates (1), and we read with interest two recent reports in the Annals. Graves and colleagues (2) found a similar substance in concentrations up to 1 ng/mL by radioimmunoassay in patients with renal impairment, and Heazlewood and colleagues(3), using a fluorescence polarization immunoassay (TDX System, Abbott Laboratories, North Chicago, Illinois), found no detectable digoxin immunoreactivity in 60 patients with acute or chronic renal failure. We report what may be an additional endogenous digoxin-like substance in three patients with combined hepatic and acute renal failure.These...References1. PUDEKSECCOMBEJACOBSONWHITFIELD MDBM. Seven different digoxin immunoassay kits compared with respect to interference by a digoxin-like immunoreactive substance in serum from premature and full-term infants. Clin Chem. 1983;29:1972-4. CrossrefMedlineGoogle Scholar2. GRAVESBROWNVALDES SBR. An endogenous digoxin-like substance in patients with renal impairment. Ann Intern Med. 1983;99:604-8. LinkGoogle Scholar3. HEAZLEWOODHEAZLEWOODJELLETT VRL. An endogenous digoxin-like substance and renal failure [Letter]. Ann Intern Med. 1984;100:618. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. HENRY GAULT, M.D.; SUDESH C. VASDEV, PH.D.; LINDA L. LONGERICH, M.SC.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySpecial Issues in Therapeutic Drug Monitoring in Patients With Uremia, Liver Disease, and in Critically Ill PatientsDigoxinTherapeutic Drug Monitoring of DigoxinEndogenous glycosides in critically ill patientsEndogenous and Exogenous Digoxin-like Immunoreactive SubstancesComparison of Microparticle Enzyme and Fluorescence Polarization Immunoassays in Pediatric Patients Not Receiving DigoxinA Critical Evaluation of Different Assays for the Determination of Digitoxin in Human Serum.Digoxin-like immunoreactive substance in liver failure: effect of liver transplantation and relationship to presence of hepatic encephalopathyComparison of Different Assays for the Determination of Digoxin in Human SerumInfluence of digoxin-like immunoreactive factor on late complications in patients with diabetes mellitusThe Use of Cardiovascular Drugs in Chronic Renal FailureDigoxin-like Immunoreactive Substances in the Plasma of Intensive Care Unit Patients: Relationship to Organ DysfunctionDigoxin-like factors in liver diseaseHow to digitalize and to maintain optimal digoxin levels in cogestive heart failureA Comparative Trial of Digoxin and Digitoxin in the Treatment of Congestive Heart FailureDigoxin-like immunoreactive substances in severe acute liver disease due to viral hepatitis and paracetamol overdoseDigoxin-Like Immunoreactive Substance (DLIS) in Liver Disease: Comparison of Clinical and Laboratory Parameters in Patients with and without DLISDigitalis-like factors in plasma of healthy human adultsHigh-performance liquid chromatographic analysis of an endogenous digoxin-like immunoreactive substance in uremic serum 1 October 1984Volume 101, Issue 4Page: 567-568KeywordsAcute renal failureAttentionBloodImmunoassaysInfantsRadioimmunoassaysRenal failure ePublished: 1 December 2008 Issue Published: 1 October 1984 PDF downloadLoading ...