Hodgkin's Disease: Intramedullary Phagocytosis with Pancytopenia
Authors: LOUIS Y. KORMAN
Journal: Annals of Internal Medicine (1979)

Brief Reports1 July 1979Hodgkin's Disease: Intramedullary Phagocytosis with PancytopeniaLOUIS Y. KORMAN, M.D., J. ROBERT SMITH, M.D., STEPHEN A. LANDAW, M.D., Ph.D., FREDERICK R. DAVEY, M.D.LOUIS Y. KORMAN, M.D.Search for more papers by this author, J. ROBERT SMITH, M.D.Search for more papers by this author, STEPHEN A. LANDAW, M.D., Ph.D.Search for more papers by this author, FREDERICK R. DAVEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-60 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBone marrow failure as a result of marrow involvement has been considered the major cause of pancytopenia in patients with Hodgkin's disease. We describe here the case of a patient with lymphocyte-depletion Hodgkin's disease in which the destruction of blood elements by intramedullary macrophages resulted in severe, refractory pancytopenia.A 62-year-old white man presented with a 2-month history of night sweats and weight loss. At physical examination he was icteric; his temperature was 38 °C, pulse 90/min, respiratory rate 16/min, and blood pressure 90/60 mm Hg. Liver span measured 13 to 14 cm; the spleen tip was palpable. Ascites and...References1. MURPHY S and GARDNER F. Effect of storage temperature on maintenance of platelet viability: deleterious effect of refrigerated storage. N Engl J Med. 1969;280:1094-8. CrossrefMedlineGoogle Scholar2. NEIMAN R, ROSEN P, and LUKES R. Lymphocyte-depletion Hodgkin's disease: a clinicopathological entity. N Engl J Med. 1973;288:751-5. CrossrefMedlineGoogle Scholar3. COHEN J. Idiopathic thrombocytopenic purpura in Hodgkin's disease. Cancer. 1978;41:743-6. CrossrefMedlineGoogle Scholar4. EISNER E, LEY A, and MAYER K. Coombs'-positive hemolytic anemia in Hodgkin's disease. Ann Intern Med. 1967;66:258-73. LinkGoogle Scholar5. GUERRA L, NAJMAN A, HOMBERG J, DUHAMEL G, and ANDRÉ R. Autoanticorps multiples au cours d'une maladie de Hodgkin. Nouv Rev Fr Hematol. 1969;9:601-10. MedlineGoogle Scholar6. MARTON P. Erythrophagocytosis in human bone marrow as disclosed by iliacal bone biopsies. Scand J Haematol. 1975;14:153-9. CrossrefMedlineGoogle Scholar7. DAMESHEK W and SCHWARTZ S. Acute hemolytic anemia (acquired hemolytic icterus, acute type). Medicine (Baltimore). 1940;19:231-7. CrossrefGoogle Scholar8. CHANDRA P, CHAUDHERY S, ROSNER F, and KAGEN M. Transient histiocytosis with striking phagocytosis of platelets, leukocytes, and erythrocytes. Arch Intern Med. 1975;135:989-91. CrossrefMedlineGoogle Scholar9. URANO Y, TANGE T, and NAKAZAWA M. Destruction intramédullaire des plaquettes dans un cas de purpura thrombopénique idiopathique. Nouv Presse Med. 1976;5:928-9. MedlineGoogle Scholar10. BYRNE G and RAPPAPORT H. Malignant histiocytosis. Gann Monogr Cancer Res. 1973:15:145-62. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LOUIS Y. KORMAN, M.D.; J. ROBERT SMITH, M.D.; STEPHEN A. LANDAW, M.D., Ph.D.; FREDERICK R. DAVEY, M.D.Affiliations: Veterans Administration Medical Center Upstate Medical Center Syracuse, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySequential Transplants for Respective Relapse of Hodgkin Disease and Hemophagocytic LymphohistiocytosisProlonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: a case reportHodgkin's lymphoma, Epstein-Barr virus reactivation and fatal haemophagocytic syndromeAspects étiologiques des hémophagocytoses réactionnelles: étude rétrospective chez 99 patientsHemolytic anemia and cancerSyndrome d'activation macrophagique : un diagnostic à évoquer devant une pancytopénie fébrile inexpliquée en réanimationA case of histiocytic medullary reticulosis complicated with x-ray-irradiated oral cancerA 26-year-old man with Hodgkin's disease and rapidly progressive pancytopeniaBone Marrow Findings in Malignant Histiocytosis and/or Malignant Lymphoma with Concurrent Hemophagocytic SyndromeFatal Virus-Associated Hemophagocytic Syndrome in a Young Adult Producing Nontraumatic Splenic RuptureHematologic manifestations of malignancyPeripheral T-cell lymphoma presenting as hemophagocytic syndromeHaemophagocytic syndrome complicating acute lymphoblastic leukaemiaHistiocytic cytophagic panniculitisMediastinal Germ Cell Tumor Associated with the Hemophagocytic SyndromeThomas J. 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