tbuckley/cabot-search huggingface dataset:
Phentolamine for Primary Pulmonary Hypertension
Authors: SE DO CHA
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 December 1979Phentolamine for Primary Pulmonary HypertensionSE DO CHA, M.D., MICHAEL KIRSCHBAUM, D.O., VLADIR MARANHAO, M.D., EMMONS PAINE, M.D., ALDEN S. GOOCH, M.D.SE DO CHA, M.D.Search for more papers by this author, MICHAEL KIRSCHBAUM, D.O.Search for more papers by this author, VLADIR MARANHAO, M.D.Search for more papers by this author, EMMONS PAINE, M.D.Search for more papers by this author, ALDEN S. GOOCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-6-927_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the May issue, Ruskin and Hutter (1) reported a case of primary pulmonary hypertension in a patient who showed impressive symptomatic and hemodynamic improvement after a trial of phentolamine. We have studied another case using similar protocol and relate a different experience.A 21-year-old white woman was found to have abnormal chest roentgenogram and was referred for evaluation in 1975. At that time she was asymptomatic. She had a palpable second heart sound and grade II/VI ejection systolic murmur at base. Electrocardiogram findings were normal. Vectorcardiogram showed right ventricular hypertrophy. Chest roentgenogram revealed an enlarged pulmonary...Reference1. RUSKINHUTTER JA. Primary pulmonary hypertension treated with oral phentolamine. Ann Intern Med. 1979;90:772-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Deborah Heart and Lung Center Browns Mills, NJ 08015 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimary pulmonary hypertension: A look at the futureDoes Pulmonary Vasoconstriction Play an Important Role in Patients with Primary Pulmonary Hypertension?Vasodilator Therapy for Primary Pulmonary Hypertension Limitations and HazardsMILTON PACKER, M. D.Calcium channel blockers in hypoxic pulmonary hypertensionManagement of primary pulmonary hypertension.Vasodilator Therapy for Primary Pulmonary HypertensionNitroglycerin therapy in the management of pulmonary hypertensive disordersDrugs in the Treatment of Primary Pulmonary Arterial HypertensionDeleterious Effects of Hydralazine in Patients with Pulmonary Hypertension 1 December 1979Volume 91, Issue 6Page: 927-928KeywordsElectrocardiographyHeartHemodynamicsPulmonary hypertensionSystolic ejection murmurThorax Issue Published: 1 December 1979 PDF downloadLoading ...
FRACTURES OF THE SHAFT OF THE FEMUR
Authors: W. K. WEST
Journal: JAMA (1927)

This report gives the results of treatment in ten cases of fracture of the shaft of the femur in which adhesive traction in connection with a plaster spica was used. No compound fractures will be considered.  The points to be remembered in treating a fracture of the shaft of the femur are: (1) union; (2) length; (3) alinement; (4) apposition, and (5) resulting conditions of adjacent joints. In addition, there are such general considerations as the condition of the patient; the age of the patient; the condition of the skin; accessibility to a properly equipped hospital, and the training of the individual surgeon.  In recent years there has been a tendency toward operations in the treatment of these fractures. On account of the many tragic results following this procedure, the pendulum has swung back to the conservative method of treatment. The closed methods are being used in the greater percentage
Authors' reply to Fishman and Soutter
Authors: D. Rojas-Rueda, A. de Nazelle, M. J. Nieuwenhuijsen
Journal: BMJ (2011)

We started with the assumption that 90% of Bicing users previously made the same trip by car and conducted further (sensitivity) analyses using other scenarios of mode shift (assuming that 9.6% of Bicing users came from cars, 55.1% from public transport, and 26.1% from walking) (see web appendix to …
A Case of Pethidine Sensitivity
Authors: D. Zuck
Journal: BMJ (1951)

two were apparently undetected ambulatory cases and were able to develop a chronic carrier state.Despite the variety of medical and surgical procedures that have been advocated to rid the individual of his carrier con- dition, and despite the introduction of chloramphenicol, it would appear that the treatment of the carrier state in typhoid fever still has to be solved.
IgA autoantibodies bind to pemphigus vulgaris antigen in a case of intraepidermal neutrophilic IgA dermatosis
Authors: Catherine Prost, Liliane Intrator, Janine Wechsler, Celeste Lebbe, Martine Bagot, Jean-Claude Roujeau, Louis Dubertret, Jean Revuz
Journal: Journal of the American Academy of Dermatology (1991)
Hippocampus, recognition, and recall: A new twist on some old data?
Authors: Jonathan K. Foster
Journal: Behavioral and Brain Sciences (1999)

This commentary attempts to reconcile the predictions of Aggleton &amp; Brown's theoretical framework with previous findings obtained from experimental tests of laboratory animals with selective hippocampal lesions. Adopting a convergent operations approach, the predictions of the model are also related to human neuroimaging data and to other complementary research perspectives (cognitive, computational, psychopharmacological).
Asthma care in Darley Dale: general practitioner audit.
Authors: C. R. Martys
Journal: BMJ (1992)

OBJECTIVE--To complete a first audit cycle of asthma care in Darley Dale after starting an asthma clinic. DESIGN--Pre-clinic (1989) and post-clinic (1990) analysis of medical records of patients with asthma. SETTING--A group practice in Derbyshire. PATIENTS--161 pre-clinic, 238 post-clinic patients with asthma. MAIN OUTCOME MEASURES--Term "asthma" in the patient9s computerised problem list, recording of peak expiratory flow rate, smoking history, clinical review, medication, and hospital admissions for asthma. RESULTS--There were significant improvements post-clinic with respect to the term "asthma" in the computer file (1989, 93/161 (58%); 1990, 233/238 (98%) (difference 0.40; 95% confidence interval 0.32 to 0.48)); at least one peak flow measurement (1989, 24/161 (15%); 1990, 143/238 (60%) (0.45; 0.37 to 0.53)); three or more peak flow measurements (1989, 15/161 (9%); 1990, 40/238 (17%) (0.08; 0.02 to 0.14)); and smoking history (1989, 24/161 (15%); 1990, 133/238 (56%) (0.41; 0.33 to 0.49)). There were no significant differences post-clinic with respect to asthma reviewed at least once (1989, 61/161 (38%); 1990, 74/238 (31%) (0.07; -0.03 to 0.17)); recording long term medication; treating acute asthma; or ratio of average to best peak flow rate of 38 patients who had one or more measurements (1989, 31/38 (82%); 1990, 34/38 (89%) (0.08; -0.08 to 0.24)). CONCLUSIONS--Setting up an asthma clinic resulted in better recording of data relevant to patients with asthma. However, objective improvement in patients9 asthma could not be detected. Renewed emphasis on prophylactic measures may result in measurable improvement in these patients9 asthma in the future.
Dissociation Between ln-111 Chloride and Tc-99m Colloid Bone Marrow Scintigraphy in Refractory Anemia with Excess Blasts
Authors: HISAO ITOH, MIE KANAMORI, NORIO TAKAHASHI
Journal: Clinical Nuclear Medicine (1990)

Marked renal uptake of ln-111 was found in a patient with refractory anemia with excess blasts (RAEB). A 46-yearold man was admitted to the hospital with severe anemia and splenomegaly. Bone marrow scintigraphy was performed using ln-111 chloride and Tc-99m tin colloid, and there was a strikingly different distribution between these two agents. A bone marrow aspirate from the sternum revealed myeloid dominant hypercellularity with excess blasts, and he was finally diagnosed as having RAEB. Repeated blood transfusions resulting in a saturation of transferrin seemed to be a cause of the dissociation.
Identification of an alternative CD20 transcript variant in B-cell malignancies coding for a novel protein associated to rituximab resistance
Authors: Carole Henry, Marina Deschamps, Pierre-Simon Rohrlich, Jean-René Pallandre, Jean-Paul Rémy-Martin, Mary Callanan, Alexandra Traverse-Glehen, Camille GrandClément, Francine Garnache-Ottou, Remy Gressin, Eric Deconinck, Gilles Salles, Eric Robinet, Pierre Tiberghien, Christophe Borg, Christophe Ferrand
Journal: Blood (2010)
Spot-blot hybridization assay for the detection of hepatitis b virus dna in serum: Factors determining its sensitivity and specificity
Authors: Eike Walter, Hubert E. Blum, Wolf-Bernhard Offensperger, Christine Zeschnigk, Silke Offensperger, Wolfgang Gerok
Journal: Hepatology (1987)

Factors determining the sensitivity and specificity of the spot-blot hybridization technique for the detection of hepatitis B virus DNA in serum were systematically investigated. Methods for pretreatment of serum samples, mode of application of the samples to the transfer membranes, blot treatment and hybridization conditions were all found to affect the sensitivity of the assay. The optimum hybridization procedure was found to be incubation of serum samples with salt, NaOH, formaldehyde and detergent, followed by spot application of the samples. This method specifically detected hepatitis B virus DNA in serum with a sensitivity 5 to 15 times higher than the presently used assay procedures.
Pin1 regulates parathyroid hormone mRNA stability
Authors: Rajiv Kumar
Journal: Journal of Clinical Investigation (2009)

Secondary hyperparathyroidism often occurs in chronic kidney disease (CKD) and vitamin D deficiency, resulting in increased fractures and mortality. Understanding factors that stimulate parathyroid hormone (PTH) synthesis is important for devising methods to treat this condition. Previous work has demonstrated that murine Pth mRNA levels are regulated by proteins that bind AU-rich elements (AREs) within the 3' UTR region of Pth mRNA and influence Pth mRNA stability. In this issue of the JCI, Nechama et al. demonstrate that in murine secondary hyperparathyroidism associated with CKD or Ca deficiency, the activity of Pin1, a peptidyl-prolyl isomerase, is reduced (see the related article beginning on page 3102). Reduced Pin1 activity resulted in the phosphorylation and degradation of an ARE-binding protein, K-homology splicing regulator protein (KSRP), which normally enhances the degradation of Pth mRNA. The activity of other ARE-binding proteins, such as AU-rich binding factor 1 (AUF1), that increase Pth mRNA stability, was increased, thereby increasing PTH synthesis. This work suggests new ways by which to regulate PTH synthesis in secondary hyperparathyroidism.
Projected Impacts of Climate Change on Environmental Suitability for Malaria Transmission in West Africa
Authors: Teresa K. Yamana, Elfatih A.B. Eltahir
Journal: Environmental Health Perspectives (2013)

Background: Climate change is expected to affect the distribution of environmental suitability for malaria transmission by altering temperature and rainfall patterns; however, the local and global impacts of climate change on malaria transmission are uncertain.Objective: We assessed the effect of climate change on malaria transmission in West Africa.Methods: We coupled a detailed mechanistic hydrology and entomology model with climate projections from general circulation models (GCMs) to predict changes in vectorial capacity, an indication of the risk of human malaria infections, resulting from changes in the availability of mosquito breeding sites and temperature-dependent development rates. Because there is strong disagreement in climate predictions from different GCMs, we focused on the GCM projections that produced the best and worst conditions for malaria transmission in each zone of the study area.Results: Simulation-based estimates suggest that in the desert fringes of the Sahara, vectorial capacity would increase under the worst-case scenario, but not enough to sustain transmission. In the transitional zone of the Sahel, climate change is predicted to decrease vectorial capacity. In the wetter regions to the south, our estimates suggest an increase in vectorial capacity under all scenarios. However, because malaria is already highly endemic among human populations in these regions, we expect that changes in malaria incidence would be small.Conclusion: Our findings highlight the importance of rainfall in shaping the impact of climate change on malaria transmission in future climates. Even under the GCM predictions most conducive to malaria transmission, we do not expect to see a significant increase in malaria prevalence in this region.Citation: Yamana TK, Eltahir EA. 2013. Projected impacts of climate change on environmental suitability for malaria transmission in West Africa. Environ Health Perspect 121:1179–1186; http://dx.doi.org/10.1289/ehp.1206174
Free Cefixime in Community Health Centers
Authors: Cynthia Carmichael
Journal: JAMA (1990)

<h3>To the Editor. —</h3> As family practitioners working in community health centers, we were dismayed to receive a letter (March 1, 1990) informing us of the National Association of Community Health Centers' involvement with the "Suprax Family Health Fund." Lederle Laboratories has donated $10 million worth of cefixime to be distributed free of charge to patients at community health clinics. Cefixime, a third-generation cephalosporin, is marketed by Lederle for "the treatment of otitis media, pharyngitis, tonsillitis, acute bronchitis, acute exacerbations of chronic bronchitis, and uncomplicated urinary tract infections." The<i>Medical Letter on Drugs and Therapeutics</i>reviewed clinical trials comparing cefixime with amoxicillin and cefaclor in the treatment of urinary tract infection, otitis media, pharyngitis, and bronchitis and concludes that "cefixime... demonstrated no clinical advantage over previously available drugs including some that cost much less."<sup>2</sup>We are concerned that using a third-generation cephalosporin to treat uncomplicated infections may select for
"Practices being railroaded" into consortiums, GP leader claims
Authors: J. Wise
Journal: BMJ (2011)

Tensions are starting to emerge between some grassroots GPs and pathfinder consortiums as the government’s changes to the NHS get under way. Meanwhile, a survey of GP pathfinder consortiums finds that many are planning to outsource areas of commissioning support to the private sector.

GPs in Buckinghamshire and Berkshire have told their local medical council that they did not feel fully informed about what was happening in their local emerging consortiums and complained of a lack of consultation on commissioning decisions.

At a local medical council meeting Bracknell GPs expressed concern that the agenda seemed to be led by a limited group of GPs. They also said they were feeling under pressure to join the emerging consortium. And they called for a clear divide to be established between any current and possible future provider organisations and the GP commissioning organisation.

Paul Roblin, chief executive of Buckinghamshire, Berkshire and Oxfordshire local medical councils, told the BMJ : “Some GPs in Buckinghamshire …
How to Make More Published Research True
Authors: John P. A. Ioannidis
Journal: PLoS Medicine (2014)

N Currently, many published research findings are false or exaggerated, and an estimated 85% of research resources are wasted.N To make more published research true, practices that have improved credibility and efficiency in specific fields may be transplanted to others which would benefit from them-possibilities include the adoption of large-scale collaborative research; replication culture; registration; sharing; reproducibility practices; better statistical methods; standardization of definitions and analyses; more appropriate (usually more stringent) statistical thresholds; and improvement in study design standards, peer review, reporting and dissemination of research, and training of the scientific workforce.N Selection of interventions to improve research practices requires rigorous examination and experimental testing whenever feasible.N Optimal interventions need to understand and harness the motives of various stakeholders who operate in scientific research and who differ on the extent to which they are interested in promoting publishable, fundable, translatable, or profitable results.N Modifications need to be made in the reward system for science, affecting the exchange rates for currencies (e.g., publications and grants) and purchased academic goods (e.g., promotion and other academic or administrative power) and introducing currencies that are better aligned with translatable and reproducible research.
The effects of ultraviolet light irradiation on viral infections
Authors: M. NORVAL, A. EL-GHORR, J. GARSSEN, H. LOVEREN
Journal: British Journal of Dermatology (1994)

Exposure to ultraviolet radiation is associated with the development of cutaneous carcinomas, and with suppression of immune responses to a variety of antigens, including those of fungal, bacterial and parasitic origin, and contact sensitizers. UV irradiation also influences viral infections. It can affect viral mutation, the photolocalization of viral exanthems, viral oncogenesis, activation of viral genomes, and the suppression of immune responses to viruses. The evidence for, and mechanisms involved in, each of these categories is presented, and the effect of UV radiation on the virus‐host interaction, particularly during persistent infections, is discussed.
Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate.
Authors: T Münzel, A Mülsch, J Holtz, H Just, D G Harrison, E Bassenge
Journal: Circulation (1992)

BACKGROUND L-Methionine potentiates systemic hemodynamic effects of intravenous glyceryl trinitrate (GTN) in tolerant and nontolerant patients to a similar extent as N-acetylcysteine (NAC). This potentiation of GTN action by L-methionine has been attributed to enhanced intracellular formation of nitrosothiols, known to be potent stimulators of soluble guanylyl cyclase. This study was performed to analyze directly the effects of L-methionine on GTN-induced dilation of large epicardial arteries and the venous capacitance system of the dog in the tolerant and nontolerant states. Cultured rat aortic vascular smooth muscle cells and purified guanylyl cyclase were used to study potential intracellular and extracellular mechanisms responsible for this interaction. METHODS AND RESULTS In awake nontolerant dogs, L-methionine (100 mg/kg) potentiated the tachycardic response to GTN (5.0 and 15 micrograms/kg/min) and enhanced the hypotensive action of GTN (1.5 and 5.0 micrograms/kg/min) in anesthetized, nonreflexic dogs. In nontolerant and tolerant dogs, however, L-methionine did not alter the dose-response of large epicardial artery dilation to intravenous GTN challenges and did not modify nitrate tolerance of the low pressure system of the dog. The infusion of L-methionine (100 mg/kg) significantly increased plasma methionine levels (from 52 +/- 12 to 1,141 +/- 239 microM), cystine levels (from 12 +/- 4 to 26 +/- 7 microM), but not homocystine levels. In vitro, the L-methionine conversion product L-cysteine (0.1-1.0 mM) but not homocysteine significantly enhanced the augmentation of purified guanylyl cyclase activity by GTN (100 microM). Incubation of cultured rat aortic smooth muscle cells with L-methionine (10 microM or 1 mM) did not result in a significant increase of free intracellular sulfhydryl group content. CONCLUSIONS The L-methionine conversion product L-cysteine mediates tolerance independent the potentiation of GTN action. This may result from an L-cysteine-induced formation of a vasoactive metabolite of GTN (nitric oxide) or nitrosothiol. This effect occurs primarily in the resistance vessel circulation, not in large epicardial arteries and veins. The lack of effect of L-methionine on sulfhydryl group content in large conductance vessels indicates that hepatic L-methionine metabolism constitutes the significant source of L-cysteine. These findings strongly suggest that administration of sulfhydryl-group precursor L-methionine does not represent a therapeutic alternative to a nitrate-free interval to restore nitrate sensitivity in tolerant large epicardial arteries and veins.
WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4
Authors: Qian Liu, Haoqian Chen, Teresa Ojode, Xiangxi Gao, Sandra Anaya-O'Brien, Nicholas A. Turner, Jean Ulrick, Rosamma DeCastro, Corin Kelly, Adela R. Cardones, Stuart H. Gold, Eugene I. Hwang, Daniel S. Wechsler, Harry L. Malech, Philip M. Murphy, David H. McDermott
Journal: Blood (2012)
The Relevance of Psychiatric and Somatic Comorbidity in Depressed Chronic Benzodiazepine Users
Authors: Jaap E. Couvée, Abraham Bakker, Frans G. Zitman
Journal: Psychotherapy and Psychosomatics (2002)

&lt;i&gt;Background:&lt;/i&gt; Comorbid conditions may add to the burden of depressed patients and hamper their treatment. We therefore investigated the impact of anxiety disorders and somatic comorbidity in a group of depressed chronic benzodiazepine users on disease status, treatment, benzodiazepine history and discontinuation outcome. &lt;i&gt;Methods:&lt;/i&gt; At screening for a discontinuation programme, full psychiatric status was determined using the MINI-interview and psychopathology was assessed using several rating scales. Relevant medical history, including surgeries, was recorded as well. &lt;i&gt;Results:&lt;/i&gt; Patients with comorbid anxiety disorders were 8 years younger (p &lt; 0.001), more anxious (p = 0.004) and reported more benzodiazepine withdrawal symptoms (p = 0.011) than depressed patients without comorbid anxiety disorders. They also had been using more long-acting benzodiazepines (p = 0.003), in higher dosages (p = 0.019). However, this did not result in more difficulty in tapering off benzodiazepines, either at post-test, or at follow-up 2.3 years later. Somatic comorbidity was not associated with the level of psychopathology and not related to the outcome of the discontinuation programme. &lt;i&gt;Conclusions:&lt;/i&gt; Comorbid anxiety disorders are associated with a more severe disease status in depressed chronic benzodiazepine users, but have no influence on the benzodiazepine discontinuation. Somatic comorbidity has no impact on the severity of the psychopathology, or on benzodiazepine discontinuation.
Daily Bisphenol A Excretion and Associations with Sex Hormone Concentrations: Results from the InCHIANTI Adult Population Study
Authors: Tamara Galloway, Riccardo Cipelli, Jack Guralnik, Luigi Ferrucci, Stefania Bandinelli, Anna Maria Corsi, Cathryn Money, Paul McCormack, David Melzer
Journal: Environmental Health Perspectives (2010)

Bisphenol A (BPA) is a high production volume chemical widely used in packaging for food and beverages. Numerous studies have demonstrated that BPA can alter endocrine function in animals, yet human studies remain limited.
Bihormonal theory of diabetes gets solid backing
Authors: Catherine Macek
Journal: JAMA (1982)

Researchers at the University of Arizona, Tucson, have discovered evidence to support the "bihormonal" theory of diabetes—that the disease is caused by an excess of glucagon as well as a deficiency of insulin. Professor of chemistry Victor J. Hruby, PhD, working with Marvin D. Bregman, PhD, and Dev Trivedi, MS, produced an analog of glucagon ([1-Nα-trinitrophenylhistidine, 12-homoarginine] glucagon, or THG) by altering the side groups of two amino acids on the hormone. The resulting THG is a potent antagonist of the glucagon-stimulated adenylate cyclase system in rat liver. It presumably works by reversibly binding to glucagon receptors on liver cells, competing successfully with glucagon and thereby preventing glycogenolysis (and release of glucose) in the liver. The substance was tested for its ability to lower blood glucose concentrations in diabetic rats by David G. Johnson, MD, associate professor of pharmacology, and Camy Ulichny Goebel, of the Department of Internal Medicine at