tbuckley/cabot-search huggingface dataset:
Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization.
Authors: S S Reddy, V Lauris, C R Kahn
Journal: Journal of Clinical Investigation (1988)

Insulin receptor function was examined in cultured skin fibroblasts from three patients with leprechaunism (Ark-1, Minn-1, and Can-1), a rare syndrome of severe insulin resistance and neonatal growth retardation. All three patients cell lines demonstrated insulin binding less than 15% of control. This was primarily due to reduced affinity of the receptor in Can-1 and due to reduced number of receptors in the other two cell lines (Ark-1 and Minn-1). When expressed as a fraction of total insulin bound, the percentage of cell-associated insulin internalized and degraded did not differ between the patient cell lines and the controls. However, chloroquine, which inhibited degradation by 50% in the control cells, had no effect in the cells from the patients. When normalized to insulin binding, insulin receptor autophosphorylation was normal in cells from Can-1, but reduced in those of Ark-1 and Minn-1. In contrast, the receptor-associated tyrosine kinase activity toward exogenous substrates was decreased in all three patient cell lines. These results suggest that leprechaunism is a biochemically heterogenous disease associated with a variety of alterations in receptor function. Cells from Ark-1 and Minn-1 exhibit parallel alterations in receptor autophosphorylation and kinase activity. Cells from Can-1 demonstrate normal receptor autophosphorylation but reduced kinase activity, thus displaying a unique form of a mutant insulin receptor. Despite reduced kinase activity, all three cell lines exhibit normal rates of insulin internalization, but decreased lysosomal-mediated degradation. Our data imply that receptor autophosphorylation and kinase activity may be regulated separately and that kinase activity may be linked to insulin degradation, but not necessarily internalization.
Rapid pacing heart failure
Authors: J. N Cohn
Journal: Cardiovascular Research (1992)

Journal Article Rapid pacing heart failure Get access Jay N Cohn Jay N Cohn Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 8, August 1992, Page 815, https://doi.org/10.1093/cvr/26.8.815 Published: 01 August 1992
The Patient with Chronic Renal Failure: A Marginal Man
Authors: MELANIE K. LANDSMAN
Journal: Annals of Internal Medicine (1975)

Four years of experience in counseling more than a hundred patients with renal disease has led to a specific overview of a basic problem in self-image. Despite vast differences in patient personalities and life styles, there is one outstanding common element that has been seen repeatedly. These patients all share a desperate struggle to determine for themselves a realistic set of expectations and goals. They tend, after the initial impact of illness dissipates, to find themselves adrift somewhere between the world of the sick and the world of the well; they are, in effect, marginal men.
Value of an Exfoliative-Cytology Study in a Small Community
Authors: Karl T. Phillips
Journal: New England Journal of Medicine (1960)

THIS is a report of the results of a free cytologic-smear program made possible by a $17,000 gift from a generous patient with cancer. The program was under the direction of the Tumor Clinic at the Day Kimball Hospital in Putnam, Connecticut. Twenty physicians obtained the smears during routine office examinations. All the smears were examined by the Hartford Hospital Cytology Laboratory, and reports were recorded by the Secretary of its tumor clinic before they were sent to the attending physicians.From May, 1955, when this program was started, until August, 1959 (four and a quarter years), 10,331 smears were . . .
Narrow QRS Ventricular Tachycardia
Authors: John J. Hayes, Robert B. Stewart, H. Leon Greene, Gust H. Bardy
Journal: Annals of Internal Medicine (1991)

Objective: To determine the frequency and clinical characteristics of narrow QRS ventricular tachycardia (QRS duration ≤ 0.11 seconds). Design: Consecutive survey of patients with ventricular tachycardia. Setting: Tertiary, referral-based arrhythmia service at a university medical center. Patients: Sequential sample of patients with inducible ventricular tachycardia who had a 12-lead electrocardiogram of the tachycardia available for review. Measurements and Main Results: Of 106 patients with ventricular tachycardia, 5 (4.7%; 95% CI, 2.1% to 10.6%) had ventricular tachycardia with a QRS duration ≤ 0.11 seconds. Three of the five patients were previously incorrectly diagnosed as having supraventricular tachycardia. AU five patients had at least two electrocardiographic findings other than QRS duration to suggest ventricular tachycardia. Conclusions: Narrow QRS ventricular tachycardia should be considered in the differential diagnosis of narrow QRS tachycardias. Electrocardiographic findings other than QRS duration are usually present to suggest the diagnosis.
Molecular localization of human class II MT2 and MT3 determinants.
Authors: C K Hurley, R C Giles, G Nunez, R DeMars, L Nadler, R Winchester, P Stastny, J D Capra
Journal: The Journal of Experimental Medicine (1984)

The specificities of the monoclonal antibodies I-LR2 and 109d6, which recognize MT2- and MT3-like serologic determinants, respectively, have been confirmed by panel testing. In addition, the relationships of these antibodies to other monoclonal antibodies and alloantisera have been studied by means of cell surface fluorescence, complement-dependent cytotoxicity and immunoprecipitation. Using these monoclonal antibodies, molecules encoded by the HLA-D region have been isolated and characterized by amino acid sequencing and peptide mapping. By these criteria, the major populations of molecules bearing MT2- and MT3-like determinants are indistinguishable from DR molecules.
Health Care Costs
Authors: J. L. Gibbs
Journal: JAMA (1969)

<h3>To the Editor:—</h3> What prompts me to put down these thoughts on health care costs is attendance at a recent conference sponsored by the Department of Health, Education, and Welfare. It was obvious that many of the problems in the field of health care costs alluded to at the conference can only be resolved by the physician who renders the care. Physicians are not as concerned with this problem as they might be. Concern today over the spiraling costs of medical services requires the medical profession to take a closer look at the factors affecting these costs. Physicians must influence those factors that lie within their province, and enlist the aid of other agencies and the public, itself, in effecting economies. Criticism of rising health costs directed in part toward the medical profession could be overcome to a great extent by a concerted effort by the physicians to curb them.
Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas.
Authors: J Peltonen, H Larjava, S Jaakkola, H Gralnick, S K Akiyama, S S Yamada, K M Yamada, J Uitto
Journal: Journal of Clinical Investigation (1989)

VLA integrins in human skin were examined by indirect immunofluorescence utilizing antibodies recognizing the beta 1, alpha 2, alpha 3, or alpha 5 subunits. Staining of fetal, newborn, or adult skin with antibodies to beta 1, alpha 2, or alpha 3 subunits gave essentially similar staining patterns: intense staining was associated with the basal layer of the epidermis, hair follicles, and blood vessel walls. The alpha 5 subunit could be detected only in epidermis and the inner root sheath of hair follicles in fetal skin. In epidermis, the staining reaction for the beta 1 subunit was not only found in sites interfacing with the basement membrane zone, but also around the entire periphery of these cells. We speculate that these receptors might have previously unrecognized functions in cell-cell interactions or that these findings may suggest the presence of previously unrecognized ligands in the intercellular spaces of keratinocytes. Examination of nine nodular basal cell carcinomas revealed a prominent staining reaction with anti-beta 1 and anti-alpha 3 antibodies at the periphery of the tumor islands. In contrast, staining of five squamous cell carcinomas revealed either the absence of integrins or altered and variable expression. Thus, matrix components and their receptors may participate in modulation of growth, development, and organization of human skin.
LATE RESUSCITATION IN APNŒA NEONATORUM.
Authors: Elmer Glover
Journal: JAMA (1883)

<h3>Editor Journal of the American Medical Association:</h3> I desire to collect information and statistics on the resuscitation of the asphyxiated new-born where prolonged efforts at restoration have met with success. The history of any such cases, with comments or opinions, from readers of this journal, will be thankfully received and acknowledged. Terre Haute, Ind.
Liver transplantation for primary sclerosing cholangitis; predictors and consequences of hepatobiliary malignancy
Authors: B Brandsæter, Helena Isoniemi, Ulrika Broomé, Michael Olausson, Lars Bäckman, Bent Hansen, Erik Schrumpf, Antti Oksanen, Bo-Göran Ericzon, Krister Höckerstedt, Heikki Mäkisalo, Preben Kirkegaard, Styrbjörn Friman, Kristian Bjøro
Journal: Journal of Hepatology (2004)
13C-egg white breath test: a non-invasive test of pancreatic trypsin activity in the small intestine
Authors: P Evenepoel
Journal: Gut (2000)

<h3>BACKGROUND</h3> The recent availability of egg white protein highly enriched with <sup>13</sup>C has allowed breath test technology to be adapted for the study of protein digestion and absorption. Pancreatic trypsin is considered to be the key enzyme in the proteolytic cascade. <h3>AIM</h3> To evaluate trypsin activity in the small intestine of healthy volunteers and patients with pancreatic disease by a recently developed<sup>13</sup>C-egg white breath test. <h3>METHODS</h3> A total of 48 healthy volunteers and 30 patients with pancreatic disease were studied after ingestion of a test meal consisting of 22 g<sup>13</sup>C-labelled egg protein. Breath samples were taken before and after ingestion of the meal and analysed for<sup>13</sup>CO<sub>2</sub> concentration. Moreover, pancreatic trypsin output after maximal stimulation was measured in 13 patients and nine healthy volunteers. <h3>RESULTS</h3> The six hour cumulative <sup>13</sup>CO<sub>2</sub> excretion in breath was significantly lower in patients than controls (mean (SEM): 6.23 (0.82)% <i>v </i>19.16 (0.58)%, p&lt;0.0001). An excellent correlation was found between the six hour cumulative<sup>13</sup>CO<sub>2</sub> excretion and trypsin activity after maximal pancreatic stimulation. <h3>CONCLUSION</h3> The non-invasive <sup>13</sup>C-egg white breath test is promising as an indirect pancreatic proteolytic function test.
Management and Complications of Severe Pulmonary Burn
Authors: William L. Donnellan
Journal: JAMA (1965)

WITH RECENT improvements in the management of shock and sepsis due to burns, the problem of respiratory-tract damage has become increasingly important to the management of severe thermal injuries. The following case report describes the successful management of a case of deep tracheopulmonary burns, and demonstrates that bronchiectasis and bronchial stenosis may develop after recovery from the burn. <h3>Report of a Case</h3> A 5-year-old boy weighing 50 lb (22.7 kg) was burned in a tenement fire in which two siblings died and a sister was burned to a lesser degree. A half hour after the injury, the patient's pulse rate was 180 beats per minute; the temperature, 103 F (39.4 C); respirations, 40 per minute; and the blood pressure, 70/0 mm Hg. First- and second-degree burns were present over the face, ears, and scalp, together with third-degree burns over 30% of the trunk, arms, hands, and upper thighs. The pharynx
Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia
Authors: Eugene Park, Eun Ji Gang, Yao-Te Hsieh, Paul Schaefer, Sanna Chae, Lars Klemm, Sandra Huantes, Mignon Loh, Edward M. Conway, Eun-Suk Kang, Hong Hoe Koo, Wolf-Karsten Hofmann, Nora Heisterkamp, Louis Pelus, Ganesan Keerthivasan, John Crispino, Michael Kahn, Markus Müschen, Yong-Mi Kim
Journal: Blood (2011)
Interleukin-2, interleukin-12, and interferon-γ levels and risk of young adult Hodgkin lymphoma
Authors: Wendy Cozen, Parkash S. Gill, Muhammad T. Salam, Alexandra Nieters, Rizwan Masood, Myles G. Cockburn, W. James Gauderman, Otoniel Martínez-Maza, Bharat N. Nathwani, Malcolm C. Pike, David J. Van Den Berg, Ann S. Hamilton, Dennis M. Deapen, Thomas M. Mack
Journal: Blood (2007)
A year in management
Authors: R. Ayres
Journal: BMJ (1997)

How would you like a medical job with good money (£55 000 plus), flexible hours, and no on call? It sounds good—but it does exist and I have just given it up.

Perhaps not too many people have moved from being medical director to medical senior house officer, an experience which has given me a unique view of two sides of the NHS. One is a world of crowded corridors and peeling paint; of patients, bleeps, and telephones. The other is of conference suites and hotels, meetings and minutes of meetings; coffee cups and biscuits.

There has been an explosion of new managers into the NHS since 1990—20 000 or so. In every town of any size there will be a listed building, converted stately home, or modern office block full of them.

Many managers have come into health from business, bringing “market skills,” but others have come from within the NHS, especially nurses, therapists, and doctors. Some maintain a clinical commitment, but many do not, and they rapidly take to sharp suits, mobile phones, and other trappings of their new trade. It is often reckoned to be a …
Expanded Screening for HIV in the United States — An Analysis of Cost-Effectiveness
Authors: A. David Paltiel, Milton C. Weinstein, April D. Kimmel, George R. Seage, Elena Losina, Hong Zhang, Kenneth A. Freedberg, Rochelle P. Walensky
Journal: New England Journal of Medicine (2005)

Although the Centers for Disease Control and Prevention (CDC) recommend routine HIV counseling, testing, and referral (HIVCTR) in settings with at least a 1 percent prevalence of HIV, roughly 280,000 Americans are unaware of their human immunodeficiency virus (HIV) infection. The effect of expanded screening for HIV is unknown in the era of effective antiretroviral therapy.
A Biochemical Abnormality in Cerebrotendinous Xanthomatosis IMPAIRMENT OF BILE ACID BIOSYNTHESIS ASSOCIATED WITH INCOMPLETE DEGRADATION OF THE CHOLESTEROL SIDE CHAIN
Authors: T. Setoguchi, Gerald Salen, G. S. Tint, E. H. Mosbach
Journal: Journal of Clinical Investigation (1974)

Bile acid production in cerebrotendinous xanthomatosis (CTX) is subnormal, yet the activity of cholesterol 7alpha-hydroxylase, the rate-determining enzyme of bile acid synthesis, is elevated. To explain this discrepancy, bile acid precursors were sought in bile and feces of three CTX subjects. Over 10% of the total sterols excreted in bile and feces consisted of compounds more polar than cholesterol. Chromatographic analysis of the polar fractions in conjunction with gasliquid chromatography (GLC)-mass spectrometry indicated two major constituents, 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol and 5beta-cholestane-3alpha,7alpha,12alpha,24xi,25-pentol. After i.v. injection of [4-(14)C]cholesterol both bile alcohols were radioactive proving that they were derived from cholesterol. The accumulation of alcohols hydroxylated at C-25 and C-24,25 suggests that decreased bile acid synthesis in CTX results from impaired oxidation of the cholesterol side chain. This finding and the virtual absence of intermediates hydroxylated at C-26 indicate that current views of the major pathway of bile acid synthesis may require revision.
Characteristic Regional Cerebral Blood Flow Patterns in Anorexia Nervosa Patients With Binge/Purge Behavior
Authors: Tetsuro Naruo, Yoshiaki Nakabeppu, Ken-ichiro Sagiyama, Takao Munemoto, Naoko Homan, Daisuke Deguchi, Masayuki Nakajo, Shin-ichi Nozoe
Journal: American Journal of Psychiatry (2000)

The authors' goal was to investigate the effect of imagining food on the regional cerebral blood flow (rCBF) of anorexia nervosa patients with and without habitual binge/purge behavior.The subjects included seven female patients with purely restrictive anorexia, seven female patients with anorexia and habitual binge/purge behavior, and seven healthy women. Single photon emission computed tomography examination was performed before and after the subjects were asked to imagine food. Changes in rCBF count ratios (percent change) were then calculated and compared. The subjects were also asked to assess their degree of fear regarding their control of food intake.The anorexia nervosa patients with habitual binge/purge behavior had a significantly higher percent change in the inferior, superior, prefrontal, and parietal regions of the right brain than the patients with purely restrictive anorexia and the healthy volunteers. The patients with habitual binge/purge behavior also had the highest level of apprehension in regard to food intake.Specific activation in cortical regions suggests an association between habitual binge/purge behavior and the food recognition process linked to anxiety in patients with anorexia nervosa.
Sanity and Survival: Psychological Aspects of War and Peace
Authors: Samuel Friedman
Journal: JAMA (1968)

Here Dr. Frank, a psychiatrist of broad vision, speaks against war, as indeed do all men of good will. Perfection of weaponry has made the possibility of nuclear war too horrible to contemplate. Among others, Hans Bethe, the Nobel prize physicist, has stated, "both sides can now destroy each other within a day, perhaps an hour." The arms race has jeopardized the very survival of the human race. Frank vigorously supports the thesis that, despite certain risks, disarmament presents a lesser danger. In pleading for a world government, he affirms, "The formation of a genuine world state... is a necessary condition for an international system of enduring peace." The author points to lack of mass communications as one of the problems that has impaired trust among nations. Closer knowledge and more personal contacts would diminish mutual hostility. But may not familiarity breed jealousy, envy, and covetousness, as well as contempt?
The Healing Gods of Ancient Civilizations
Authors: John H. Raach
Journal: JAMA (1962)

We know that our primitive ancestors believed in varying degrees of pantheism. Nearly all peoples had their pantheons of gods and goddesses. Moreover, deities of healing were especially prevalent in these ancient cultures. Most of us know of Asklepios, the Greek god of healing, and of Imhotep, his Egyptian counterpart, but the remainder of the healing deities are virtually unknown. In this volume, a host of such gods and goddesses are presented from the ancient cultures of Europe, the Middle East, and India. Short descriptions are given of each deity, some of whom had been outstanding physicians in their day and were subsequently raised to supernatural rank by a grateful people. The ruins of temples to these gods may be found from India to Ireland. An account of the medical concepts of each of these ancient civilizations is given, with the result that one is impressed by the similarities of
NATURAL HISTORY OF RENAL FUNCTION FOLLOWING ACUTE CORONARY SYNDROME IN PATIENTS WITH IN-HOSPITAL DECLINE IN RENAL FUNCTION
Authors: Jayasree Pillarisetti, Oni Olurinde, Archana Goel, Ram Sharma, Dhanunjaya Lakkireddy, Kamal Gupta, Veterans Affairs
Journal: Journal of the American College of Cardiology (2015)
N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes.
Authors: M Watanabe, T Igarashi, T Kaminuma, T Sofuni, T Nohmi
Journal: Environmental Health Perspectives (1994)

Acetyl-CoA:N-hydroxyarylamine O-acetyltransferase is an enzyme involved in the metabolic activation of N-hydroxyarylamines derived from mutagenic and carcinogenic aromatic amines and nitroarenes. The O-acetyltransferase gene of Salmonella typhimurium has been cloned, and new Ames tester substrains highly sensitive to mutagenic aromatic amines and nitroarenes have been established in our laboratory. The nucleotide sequence of the O-acetyltransferase gene was determined. There was an open reading frame of 843 nucleotides coding for a protein with a calculated molecular weight of 32,177, which was close to the molecular weight of the O-acetyltransferase protein determined by using the maxicell technique. Only the residue of Cys69 in O-acetyltransferase of S. typhimurium and its corresponding residue (Cys68) in N-acetyltransferase of higher organisms were conserved in all acetyltransferase enzymes sequenced so far. The amino acid sequence Arg-Gly-Gly-X-Cys, including the Cys69, was highly conserved. A mutant O-acetyltransferase of S. typhimurium, which contained Ala69 instead of Cys69, no longer showed the activities of O- and N-acetyltransferase. These results suggest that the Cys69 of S. typhimurium and the corresponding cysteine residues of the higher organisms are essential for the enzyme activities as an acetyl-CoA binding site. We propose a new catalytic model of acetyltransferase for S. typhimurium and the higher organisms.