tbuckley/cabot-search huggingface dataset:
Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia.
Authors: K J Lackner, J C Monge, R E Gregg, J M Hoeg, T J Triche, S W Law, H B Brewer
Journal: Journal of Clinical Investigation (1986)

The apolipoprotein B-100 (apoB-100) gene in leukocytes and the apoB-100 messenger RNA (mRNA) and translated apolipoprotein in the livers from normal and abetalipoproteinemic individuals were evaluated. Four complementary DNA probes for apoB-100 covering the 5', middle, and 3' regions of the apoB-100 mRNA were utilized and Southern blot analysis indicated that the apoB-100 gene is present in abetalipoproteinemia without major insertions or deletions. Polyadenylated hepatic apoB-100 mRNA from two abetalipoproteinemic patients was normal in size, and the concentration of apoB-100 mRNA was increased sixfold compared with control hepatic apoB-100 mRNA levels. ApoB-100 was detected in hepatocytes of abetalipoproteinemic patients by immunohistochemical techniques. These results indicate that the biochemical defect in abetalipoproteinemic patients studied is most consistent with a posttranslational defect in apoB-100 processing or secretion with an up-regulation of the apoB-100 mRNA.
Development: Evolutionary ecology's midwife
Authors: Karthik Panchanathan, Willem E. Frankenhuis, H. Clark Barrett
Journal: Behavioral and Brain Sciences (2010)

We agree with Henrich et al. that documenting cultural universality and variability provides an indispensable window into human nature. We want to stress the mediating role development plays between evolution and culture. Moving beyond the mere documentation of universality or variability, developmental approaches can provide mechanistic explanations, linking ecology to phenotype. Combining phylogeny and adaptationism, evolutionary approaches can explain the properties of developmental systems.
To Meet the Nation's Health Needs
Authors: Robert Q. Marston
Journal: New England Journal of Medicine (1968)

IT is a high honor and privilege to deliver a lecture bearing the name of one of those remarkable families of New England — families that have helped to shape the destiny of this state, this region and the nation as a whole. Dr. Joseph Garland, in his lecture to this Society a few years ago, traced this distinguished dynasty through four generations, from Dr. George Cheyne Shattuck 1st, whose bequest endowing this lectureship was among his many outstanding legacies to medicine in Massachusetts, through his grandson, Dr. George Brune Shattuck, who appropriately delivered the first lecture in 1890, to . . .
73 TAK1 SUPPRESSES A NEMO-DEPENDENT, BUT NF-KAPPAB-INDEPENDENT PATHWAY TO LIVER CANCER
Authors: K. Bettermann, M. Vucur, J. Haybaeck, C. Liedtke, F. Tacke, M. Heikenwalder, C. Trautwein, T. Luedde
Journal: Journal of Hepatology (2010)
Crunch time for the government on alcohol pricing in England
Authors: G. Scally
Journal: BMJ (2013)

Backtracking on the minimum unit price pledge would be a public health disaster

Last week, David Cameron was questioned in parliament on a claim that the forthcoming budget speech would be used to announce that the government would not be implementing a minimum price per unit of alcohol in England.1 If the prime minister does not implement his pledge to introduce a minimum unit price for alcohol it will be not be just a policy U-turn but a wilful disregard for the health and wellbeing of the English population. According to the figures quoted in the government’s own alcohol strategy published in 2012, there were almost one million alcohol related violent crimes and 1.2 million alcohol related hospital admissions in 2010-11 alone.2 In its written evidence to the 2012 Health Select Committee, the Department of Health estimated the total costs of alcohol misuse in England at about £21bn (€24.5bn; $31.8bn) …
Bringing Patient-Centered Care to Patients With Alcohol Use Disorders
Authors: Katharine A. Bradley, Daniel R. Kivlahan
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Authors: Naomi Ori, Aya Refael Cohen, Adi Etzioni, Arnon Brand, Osnat Yanai, Sharona Shleizer, Naama Menda, Ziva Amsellem, Idan Efroni, Irena Pekker, John Paul Alvarez, Eyal Blum, Dani Zamir, Yuval Eshed
Journal: Nature Genetics (2007)
Severe Hyperosmolar Metabolic Acidosis Due to a Large Dose of Intravenous Lorazepam
Authors: Jean H Tayar, George Jabbour, Subodh J. Saggi
Journal: New England Journal of Medicine (2002)

To the Editor: In a 34-year-old woman with a history of alcohol abuse, cardiomyopathy, and AIDS, acute respiratory failure developed as a result of Escherichia coli sepsis and pneumonia. Initial laboratory studies revealed a pH of 7.2, a bicarbonate level of 8.8 mmol per liter, a partial pressure of carbon dioxide of 26 mm Hg, an anion gap of 15.4 mmol per liter, a lactate level of 6.9 mmol per liter, and a creatinine level of 1.8 mg per deciliter, with a normal blood sugar level and no ketones. After four days of treatment, the patient's acidosis was worse (pH, . . .
The Kidney Disease: Improving Global Outcomes website: Comparison of guidelines as a tool for harmonization
Authors: H. Vanbelleghem, R. Vanholder, N.W. Levin, G. Becker, J.C. Craig, S. Ito, J. Lau, F. Locatelli, C. Zoccali, K. Solez, M. Hales, N. Lameire, G. Eknoyan
Journal: Kidney International (2007)
Kinetics of CLL cells in tissues and blood during therapy with the BTK inhibitor ibrutinib
Authors: Dominik Wodarz, Naveen Garg, Natalia L. Komarova, Ohad Benjamini, Michael J. Keating, William G. Wierda, Hagop Kantarjian, Danelle James, Susan O’Brien, Jan A. Burger
Journal: Blood (2014)
Metabolic Aggressiveness in Benign Meningiomas with Chromosomal Instabilities
Authors: Daniel Monleón, José Manuel Morales, Ana Gonzalez-Segura, José Manuel Gonzalez-Darder, Rosario Gil-Benso, Miguel Cerdá-Nicolás, Concepción López-Ginés
Journal: Cancer Research (2010)

Meningiomas are often considered benign tumors curable by surgery, but most recurrent meningiomas correspond to histologic benign tumors. Because alterations in chromosome 14 among others have suggested clinical aggressiveness and recurrence, determining both the molecular phenotype and the genetic profile may help distinguish tumors with aggressive metabolism. The aim of this study was to achieve higher specificity in the detection of meningioma subgroups by measuring chromosomal instabilities by fluorescence in situ hybridization and cytogenetics and metabolic phenotypes by high-resolution magic angle spinning spectroscopy. We studied 46 meningioma biopsies with these methodologies. Of these, 34 were of WHO grade 1 and 12 were of WHO grade 2. Genetic analysis showed a subgroup of histologic benign meningioma with chromosomal instabilities. The metabolic phenotype of this subgroup indicated an aggressive metabolism resembling that observed for atypical meningioma. According to the metabolic profiles, these tumors had increased energy demand, higher hypoxic conditions, increased membrane turnover and cell proliferation, and possibly increased resistance to apoptosis. Taken together, our results identify distinct metabolic phenotypes for otherwise benign meningiomas based on cytogenetic studies and global metabolic profiles of intact tumors. Measuring the metabolic phenotype of meningioma intact biopsies at the same time as histopathologic analysis may allow the early detection of clinically aggressive tumors.
The Duck Lady
Authors: Adria Burrows
Journal: JAMA (1989)

We used to call her "the Duck Lady." The Duck Lady always sat on a stone ledge in front of our inner-city hospital with a shopping bag nearby, quacking like a duck. She was a short woman with no teeth and a dirty scarf wrapped around her head. She always wore a tattered raincoat and her feet were bare, although they were so filthy it looked almost as if she had shoes on. I wondered how she ate and if she lived anywhere. Once I saw the corner hot-dog man give her a hot dog. On rainy days she was nowhere to be seen. My classmates made fun of her at some of our teaching sessions, imitating her choppy gait and making duck sounds. One even used a drawing of her in a slide presentation, as a joke. I wondered if she knew her name, or had any family. Once,
The role of V2 vasopressin antagonists in hyponatremia
Authors: C Palm
Journal: Cardiovascular Research (2001)

Hyponatremia is a frequent electrolyte disorder. It is often found in congestive cardiac failure, liver cirrhosis, plasma volume contraction and in SiADH. In these disorders hyponatremia is caused by nonosmotic vasopressin and sustained fluid intake. This provides a rationale for V2 vasopressin receptor antagonists in the treatment of hyponatremia. There is now convincing evidence from different animal models of congestive cardiac failure that peptide and non-peptide V2 vasopressin antagonists effectively increase renal water diuresis and plasma sodium concentration. In addition, several of the experimental studies also showed an improvement of hemodynamic changes of cardiac failure in response to V2 antagonists. Data in patients indicated that oral non-peptide V2-antagonists correct hyponatremia and may improve hemodynamic derangements in cardiac failure. In addition, experimental and clinical studies of V2 antagonists have been undertaken in liver cirrhosis and SiADH. In those studies hyponatremia was improved or corrected, too. Taken together, V2 vasopressin antagonists promise to become therapeutic agents in hyponatremic disorders.
Thromboembolism Problems In the Presence of Endocardiac Catheters
Authors: Oglesby Paul
Journal: JAMA (1969)

To the Editor:—  I am writing you regarding the article, Pulmonary Thromboembolism in the Presence of an Endocardiac Pacing Catheter, by Prozan et al which appeared inThe Journal(206:1564, 1968), The authors report the case of an 88-year-old white man who died with apparent multiple areas of pulmonary infarction. The case was of particular interest since a transvenous catheter was in place in the right side of the heart and thrombi were seen along its course in the right atrium and ventricle and adjacent areas of the endocardium.  It is of course possible that the areas of thrombus formation in the right side of the heart may have represented the sources of embolic material to the lungs. However before such an assumption can be made, it would be necessary to have information regarding the leg veins. As the authors indicate, pulmonary emboli in a patient with chronic congestive
On Business and Medicine
Authors: Miles F. Shore, Harry Levinson
Journal: New England Journal of Medicine (1985)

The push is clearly on to make the delivery of health services more businesslike. National concern about the cost of health care and competition for scarce resources have led both health care institutions and providers to become preoccupied with altering traditional practices in an effort to be more successful as fiscal and administrative enterprises. Hospital trustees, once free to pursue singlemindedly the interests of their institutions, exert pressure as members of the business community to restrain hospital costs. Hospital directors, fresh from the regulatory wars of cost reimbursement, are urged to retool so that they can thrive in a competitive . . .
People in coastal regions of Asia are likely to be worst hit by climate change, report says
Authors: M. Limb
Journal: BMJ (2014)

Climate change will have a devastating effect on populations around the world but the United Kingdom is expected to be spared the worst potential effects on health by 2050, leading scientists have said.

A long awaited study, Climate Change 2014: Impacts, Adaptation, and Vulnerability , is expected to be published next week by the United Nations’ Intergovernmental Panel on Climate Change.

Extracts of a final draft published in UK newspapers this week showed that many millions of people living in coastal regions of Asia are likely to suffer the worst hardship, especially those living in cities.

Extreme weather …
Effects of anesthesia on cardiovascular control mechanisms.
Authors: S F Vatner
Journal: Environmental Health Perspectives (1978)

The manner in which general anesthesia affects circulatory control was studied by examining the effects of commonly employed anesthetics on left ventricular function and distribution of cardiac output, and the extent to which responses to physiological and pharmacological stimuli are modified by general anesthesia. While commonly employed anesthetics affect almost every aspect of the circulatory system, the importance of general anesthesia on the circulation tends to be underestimated by considering only its direct effects. More important is the modification of the organism's integrative response to any perturbation. Major differences often directionally opposite, in responses of conscious and anesthetized animals were found for reflex control of the circulation, effects of hemorrhage and alterations in preload and after load. In addition, commonly employed pharmacologic agents, e.g., cardiac glycosdies, catecholamines, and morphine sulfate exerted differing actions in the conscious and anesthetized states. Thus, while it is generally held that the overall responses to complex physiological functions such as exercise or eating can be best described in the intact, conscious organism, the importance of conducting any experiment involving integrative control of the circulation in the conscious organism should also be recognized.
Any Known Star
Authors: Gary Pasternak
Journal: Annals of Internal Medicine (2014)

Ad Libitum1 April 2014Any Known StarGary Pasternak, MDGary Pasternak, MDFrom Mission Hospice and Home Care, San Mateo, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M13-2302 Audio Reading - “Any Known Star” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Any Known Star," by G. Pasternak. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Of all the myriad mysterious thingsNot the least of which is the way heFinally allows the mechanical bed to bePlaced next to the French Doors by the courtyardWhere shafts of sunlight illuminate himWith impeccably rare andPrecise timingNow thrown ... Author, Article, and Disclosure InformationAffiliations: From Mission Hospice and Home Care, San Mateo, California.Current Author Address: Gary Pasternak, MD; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement Audio Reading - “Any Known Star” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Any Known Star," by G. Pasternak. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 1 April 2014Volume 160, Issue 7Page: 504KeywordsFallsThorax ePublished: 1 April 2014 Issue Published: 1 April 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Presenting features of polymyalgia rheumatica (PMR) and rheumatoid arthritis with PMR-like onset: a prospective study
Authors: R Caporali
Journal: Annals of the Rheumatic Diseases (2001)

To evaluate in a prospective study whether patients with polymyalgia rheumatica (PMR) and patients with rheumatoid arthritis (RA) with PMR-like onset show distinctive clinical and laboratory features.A cohort of 116 consecutive patients with bilateral girdle pain for at least one month and raised erythrocyte sedimentation rate (ESR) was studied and followed up for 12 months. Laboratory tests included determination of ESR, IgM rheumatoid factor, haemoglobin, white blood cell count, platelet count, percentage of CD8 lymphocytes, serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and glutamyltransferase concentrations.At first examination, RA was diagnosed in 22/116 (19%) patients and PMR in 94 (81%) patients. During the follow up period, 19 additional patients developed RA, and the diagnosis of PMR was confirmed in 65 (56%) patients at the end of the study. Of the clinical and laboratory features, only the presence of peripheral synovitis could differentiate patients who will develop RA from those with "true" PMR, but the positive predictive value of this feature was poor.At present, there are no clinical or routine laboratory features allowing early differentiation between PMR and RA with PMR-like onset.
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Paclitaxel-Carboplatin Alone or with Endostar for Advanced Non-small Cell Lung Cancer
Authors: Baohui Han, Qingyu Xiu, Huimin Wang, Jie Shen, Aiqin Gu, Yi Luo, Chunxue Bai, Shuliang Guo, Wenchao Liu, Zhixiang Zhuang, Yang Zhang, Yizhuo Zhao, Liyan Jiang, Jianying Zhou, Xianqiao Jin
Journal: Journal of Thoracic Oncology (2011)
Towards the development of a standard test procedure for mouthguard assessment
Authors: A Greasley, B Karet
Journal: British Journal of Sports Medicine (1997)

A simulated upper jaw, made from a rubber arch containing replaceable ceramic teeth and a renewable composite jawbone, offers promise in assessing the performance of custom made mouthguard designs. Impact tests, involving precise assessment of jaw and tooth fractures caused by projectiles of various energies and profiles, simulate conditions that approximate to common clinical observation. Such conditions offer the most sensitive indices for assessing both improved mouthguard designs and product quality and reliability. Damage caused by the dissipation of the impact energy may be transferred within this simulated oral cavity by minor changes to the impact conditions.
THE BASAL METABOLIC RATE, FASTING BLOOD SUGAR, GLUCOSE TOLERANCE, AND SIZE OF THE SELLA TURCICA IN HOMOSEXUALS
Authors: WILLIAM R. ROSANOFF, FRANCIS E. MURPHY
Journal: American Journal of Psychiatry (1944)

Basal metabolic rate determinations, fasting blood sugar determinations, glucose tolerance tests, and measurements of X-ray films of the pituitary fossae were made on a group of male homosexuals. No significant deviations from the normal were found.
Descending aortic doppler velocities after balloon-expandable stent implantation for coarctation of the aorta: are they related to pressure changes by the Bernoulli Equation?
Authors: Sebastian T. Schindera, Monica T. Young, Xiaokui Li, George D. Giraud, Huifang Wang, Grant H. Burch, Deniz Kececioglu, David J. Sahn
Journal: Journal of the American College of Cardiology (2002)
Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis
Authors: Antonin R. de Fougerolles, Andrew G. Sprague, Cheryl L. Nickerson-Nutter, Gloria Chi-Rosso, Paul D. Rennert, Humphrey Gardner, Philip J. Gotwals, Roy R. Lobb, Victor E. Koteliansky
Journal: Journal of Clinical Investigation (2000)

Adhesive interactions play an important role in inflammation by promoting leukocyte attachment and extravasation from the vasculature into the peripheral tissues. However, the importance of adhesion molecules within the extracellular matrix–rich environment of peripheral tissues, in which cells must migrate and be activated, has not been well explored. We investigated the role of the major collagen-binding integrins, α1β1 and α2β1, in several in vivo models of inflammation. mAb’s against murine α1 and α2 were found to significantly inhibit effector phase inflammatory responses in animal models of delayed-type hypersensitivity (DTH), contact hypersensitivity (CHS), and arthritis. Mice that were α1-deficient also showed decreased inflammatory responses in the CHS and arthritis models when compared with wild-type mice. Decreased leukocyte infiltration and edema formation accompanied inhibition of antigen-specific models of inflammation, as nonspecific inflammation induced by croton oil was not inhibited. This study demonstrates the importance in vivo of α1β1 and α2β1, the collagen-binding integrins, in inflammatory diseases. The study also extends the role of integrins in inflammation beyond leukocyte attachment and extravasation at the vascular endothelial interface, revealing the extracellular matrix environment of peripheral tissues as a new point of intervention for adhesion-based therapies.
Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
Authors: Daejong Jeon, Sangwoo Kim, Mattu Chetana, Daewoong Jo, H Earl Ruley, Shih-Yao Lin, Dania Rabah, Jean-Pierre Kinet, Hee-Sup Shin
Journal: Nature Neuroscience (2010)