tbuckley/cabot-search huggingface dataset:
Temporomandibular Joint Dislocation Mistaken as Dystonia
Authors: Shobhana B. Vora
Journal: JAMA (1979)

To the Editor.—  The recently encountered a case in which dislocation of the temporomandibular joint was mistaken as dystonia.  Report of a Case.—  A 42-year-old woman was admitted to the inpatient psychiatric unit for treatment of an acute exacerbation of a chronic schizophrenic disorder.  On the 18th day, she experienced a phenothiazine-induced extrapyramidal reaction, including cogwheel rigidity, bradykinesia, and orofacial dystonia with spasmodic movements of the tongue. She was given benztropine mesylate, 1 mg intramuscularly, which relieved the rigidity and bradykinesia. Her face remained distorted and she was unable to close her mouth. This problem was treated for 24 hours as a dystonic extrapyramidal side effect. Finally, the correct diagnosis of temporomandibular joint dislocation was made and the condition treated manually by the oral surgeon.  Six days later, the dislocation recurred. The patient was treated again in the oral surgery clinic; on the way back to the psychiatric unit, she
A case of severe tongue ulceration and laryngeal inflammation induced by low-dose nicorandil therapy
Authors: H-S. Jang, J-H. Jo, B-S. Kim, G-J. Jun, J-B. Lee, M-B. Kim, C-K. Oh, K-S. Kwon
Journal: British Journal of Dermatology (2004)

Sir, We read with great interest the article by Desruelles et al.1 in which the authors suggested that a minimum dosage of 30 mg per day of nicorandil may be necessary to induce oral ulceration. However, we would suggest that oral ulceration and laryngeal inflammation can occur even at lower doses of nicorandil. A 62‐year‐old man was referred to our hospital with a 1‐year history of persistent and painful ulcerative lesions at the dorsal tongue and buccal mucosa, which had resulted in significant functional impairments such as difficulty in eating and swallowing since 2002. He had no previous history of oral ulceration or allergic disorders. His oral ulcers had been recalcitrant and showed a relapsing course. Before admission, treatment with local and systemic glucocorticoids had failed to induce healing. He had been treated empirically from January 2003 with itraconazole 100 mg daily, without benefit. He had been diagnosed as having angina pectoris 2 years previously, followed by percutaneous transluminal coronary angioplasty. He had been on daily medication with aspirin 100 mg, isosorbide mononitrate 60 mg, cilostazol 100 mg and nicorandil 10 mg for 1 year, under the care of a cardiologist.
The incidences of lung cancer and breast cancer in women in Glasgow.
Authors: C. R. Gillis, D. J. Hole, D. W. Lamont, A. C. Graham, S. Ramage
Journal: BMJ (1992)

safety of bovine gangliosides was carried out in Ferrara, Italy.No case of Guillain-Barre syndrome was found, but the sample was small (18 945 person years) given the incidence of the syndrome (0-6 to 19/100000 population yearly).'Studying the aetiology of conditions whose pathophysiology and clinical course are poorly understood may be difficult and controversial.Formal epidemio- logical studies in this setting, however, can be justified only if the efficacy of the suspected causal drug is clearly delineated.This is not the case with gangliosides, and hence the Spanish National Commission of Pharmacovigilance has proposed their withdrawal.
Circulating immune complexes in cutaneous and systemic vasculitis: clinicopathological correlations.
Authors: J Barratt, M Sindrey, R Summerly, G M Aber, P Naish
Journal: Annals of the Rheumatic Diseases (1982)

A high incidence of raised levels of circulating immune complexes has found in a group of patients with idiopathic vasculitis. Serial measurements in 8 patients with systemic vasculitis showed a good correlation between clinical status and circulating immune complex levels. Some correlation existed between the constituents of circulating and tissue-bound complexes in 6 patients so studied. However, there was no correlation between apparent organ involvement and hypocomplementaemia and the levels of size of circulating immune complexes. It is concluded that the measurement of circulating immune complexes may be clinically useful in vasculitis, but that no direct evidence is yet available that they are pathogenetically related to those which are tissue-bound.
Tetracycline-Antacid Interactions
Authors: David S. Tatro
Journal: JAMA (1972)

To the Editor.—  Concerning the interaction of antibiotics with other drugs (219:206, 1972), Kabins is correct in stating that gastrointestinal binding of tetracycline with polyvalent cations (aluminum, calcium, and magnesium) may decrease the absorption of the antibiotic.  It is of interest that the absorption of tetracycline has recently been shown to be decreased by concurrent therapy with antacids in the absence of chelation.1In this instance, depressed blood levels of tetracycline were noted when the antibiotic was administered with sodium bicarbonate. Patients receiving 250-mg capsules of tetracycline and 2.0 gm of sodium bicarbonate concomitantly were compared to patients receiving tetracycline alone. Approximately a 50% decrease in absorption (as reflected by urinary tetracycline excretion) was seen for the patients given the tetracycline-sodium bicarbonate regimen. The results of this study indicate that higher pH environments (above 3) decrease the dissolution rate of tetracycline capsules and lead to lower plasma levels.
High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism
Authors: Takakazu Kawase, Yasuo Morishima, Keitaro Matsuo, Koichi Kashiwase, Hidetoshi Inoko, Hiroh Saji, Shunichi Kato, Takeo Juji, Yoshihisa Kodera, Takehiko Sasazuki
Journal: Blood (2007)
CHANGING MORPHOLOGIC PATTERNS OF RESTENOSIS WITH THE 2ND GENERATION DRUG-ELUTING STENT: A SHIFT TOWARDS FOCAL RESTENOSIS
Authors: Sahmin Lee, Chang-Hwan Yoon, Il-Young Oh, Jung-Won Suh, Young-Seok Cho, Goo-Yeong Cho, In-Ho Chae, Dong-Ju Choi, Tae-Jin Youn
Journal: Journal of the American College of Cardiology (2012)
TCT-617 Short- and long-term safety evaluation of a novel bioresorbable scaffold in a miniature swine coronary artery model
Authors: Kazuyuki Yahagi, Erica Pacheco, Masataka Nakano, Fumiyuki Otsuka, Kenichi Sakakura, OSCAR D. SANCHEZ, Elena Ladich, Frank D. Kolodgie, Antoine Lafont, Michael Joner, Renu Virmani
Journal: Journal of the American College of Cardiology (2014)
Detection of Intraluminal Tracheal Metastasis of Thyroid Papillary Carcinoma by 18F-FDG PET/CT
Authors: Elgin Ozkan, Mine Araz, Cigdem Soydal, Nuriye Ozlem Kucuk, Erkan Ibis
Journal: Clinical Nuclear Medicine (2012)

We present a case of a 66-year-old female patient with thyroid papillary carcinoma. On the fluorine-18 fluorodeoxyglucose (F18-FDG) positron emission tomography/computed tomography (PET/CT) performed for thyroglobulin elevation accompanied by negative radioiodine whole-body scan, there was an intense 18F-FDG uptake in the polypoid soft tissue invading the tracheal cartilage and extending into the lumen. Dedifferentiated tumor with high metabolic rate can be easily detected by 18F-FDG PET/CT.
Coexpression of <i>Oct4</i> and <i>Nanog</i> Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell–Like Properties and Epithelial–Mesenchymal Transdifferentiation
Authors: Shih-Hwa Chiou, Mong-Lien Wang, Yu-Ting Chou, Chi-Jen Chen, Chun-Fu Hong, Wang-Ju Hsieh, Hsin-Tzu Chang, Ying-Shan Chen, Tzu-Wei Lin, Han-Sui Hsu, Cheng-Wen Wu
Journal: Cancer Research (2010)

Abstract Epithelial–mesenchymal transition (EMT), a critical process of cancer invasion and metastasis, is associated with stemness property of cancer cells. Though Oct4 and Nanog are homebox transcription factors essential to the self-renewal of stem cells and are expressed in several cancers, the role of Oct4/Nanog signaling in tumorigenesis is still elusive. Here microarray and quantitative real-time PCR analysis showed a parallel, elevated expression of Oct4 and Nanog in lung adenocarcinoma (LAC). Ectopic expressions of Oct4 and Nanog in LACs increased the percentage of CD133-expressing subpopulation and sphere formation, enhanced drug resistance, and promoted EMT. Ectopic expressions of Oct4 and Nanog activated Slug and enhanced the tumor-initiating capability of LAC. Furthermore, double knockdown of Oct4 and Nanog suppressed the expression of Slug, reversed the EMT process, blocked the tumorigenic and metastatic ability, and greatly improved the mean survival time of transplanted immunocompromised mice. The immunohistochemical analysis demonstrated that expressions of Oct4, Nanog, and Slug were present in high-grade LAC, and triple positivity of Oct4/Nanog/Slug indicated a worse prognostic value of LAC patients. Our results support the notion that the Oct4/Nanog signaling controls epithelial–mesenchymal transdifferentiation, regulates tumor-initiating ability, and promotes metastasis of LAC. Cancer Res; 70(24); 10433–44. ©2010 AACR.
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
Authors: Alan J Russell, James J Hartman, Aaron C Hinken, Alexander R Muci, Raja Kawas, Lena Driscoll, Guillermo Godinez, Kenneth H Lee, David Marquez, William F Browne, Michael M Chen, David Clarke, Scott E Collibee, Marc Garard, Richard Hansen, Zhiheng Jia, Pu-Ping Lu, Hector Rodriguez, Khalil G Saikali, Julia Schaletzky, Vipin Vijayakumar, Daniel L Albertus, Dennis R Claflin, David J Morgans, Bradley P Morgan, Fady I Malik
Journal: Nature Medicine (2012)
Design of a Computer-Assisted Program for Therapy of Urinary Tract Infections (UTI).
Authors: A. M. Tannenberg
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Design of a Computer-Assisted Program for Therapy of Urinary Tract Infections (UTI).A. M. Tannenberg, M.D., M. E. Plaut, M.D., E. R. Gabrieli, M.D.A. M. Tannenberg, M.D.Search for more papers by this author, M. E. Plaut, M.D.Search for more papers by this author, E. R. Gabrieli, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-777_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this program is to eliminate the informational gap between expanding medical research and bedside medicine in the context of therapy for urinary tract infections (UTI). Systems analysis has established logical sequences leading to the diagnosis of UTI, criteria for urgency to treat, the required bacteriology backup, and choice of therapeutic agent. Major logical decision-points identified and information barriers that had arisen between clinician and bacteriologist were eliminated, providing a flow of pertinent information between specialists involved in the therapy of UTI. The resultant data bank contains the therapeutic agents usable for UTI along with all the pertinent... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 777-777KeywordsBacteriologySequence analysisSoftware tools Issue Published: 1 May 1970 PDF DownloadLoading ...
Abstract 1577: The Impact of M1/M2 Tumor Associated Macrophage (TAM) Polarization on Cancer Progression in NSCLC
Authors: Yi-Jing Hsiao, Sung-Liang Yu, Huei-Wen Chen, Jeremy J.W. Chen, Ang Yuan, Pan-Chyr Yang
Journal: Cancer Research (2011)

Abstract Tumor microenvironment has important influences on tumor progression. One of the effectors is tumor-associated macrophages (TAMs) that are characterized as M1/M2 by their different immune responses, induced by Th1 and Th2. In our study, we polarized THP-1 into classically (M1) and alternatively (M2) activated macrophages and evaluated some different markers to distinguish M1 and M2 subtype (M2a, M2c). M1 macrophage expressed high IL-1, IL-6, IL-12, IL23, TNF-α, and a surface maker CCR7; M2a and M2c macrophages expressed high IL-10 and a surface maker CD206, but expressed CD23 and CD163, respectively. Microarray analysis was used to evaluate the alteration of gene expression of lung cancer cell line (A549) after coculture with different subtype TAMs (M0, M1, M2a and M2c). Bioinformatics analysis indicated that TAMs mainly alter cell cycle, coagulation and cell adhesion pathways in tumor cells. The M0, M2a and M2c promoted the invasion ability of A549 after coculture for 2days. Otherwise, M1 condition medium reduced cell viability and induced apoptosis of A549 but not H1299, the p53 null cell line. Moreover, the M2 macrophage condition medium but not M1 increased the drug resistance ability of A549 cells after long-term coculture. More importantly, in vivo tumorigenesis assay indicated that M2 can promote tumor growth and angiogenesis. Different subtypes of macrophages can modify behaviors of cancer cells and may contribute to tumor progression. Further studies in the detailed mechanisms involved in the interaction of TAMs and cancer cells will unveil the role of macrophages in tumor progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1577. doi:10.1158/1538-7445.AM2011-1577
Anesthesia and Monoamine Oxidase Inhibitors
Authors: Clifford Gevirtz
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I wish to register my strong disagreement with your consultants Drs Hirshman and Lindeman<sup>1</sup>and their assertion that it is safe to administer an elective anesthetic to a patient receiving monoamine oxidase inhibitors.<sup>1</sup>I believe that theirs is a minority viewpoint. An informal telephone survey of 60 board-certified anesthesiologists attending the Postgraduate Assembly in Anesthesia in New York, NY, on December 15 revealed that only 8 (13.3%) would administer an anesthetic in the case described. Of those who answered affirmatively, all stated that they would perform invasive blood pressure monitoring before proceeding. Several major textbooks<sup>2-4</sup>and the<i>Physicians' Desk Reference</i><sup>5</sup>all emphasize the need to discontinue monoamine exidase inhibitors for 2 weeks prior to the administration of an anesthetic. There have been no published case reports using alfentanil or sufentanil in patients receiving monoamine oxidase inhibitors. At the very least, a fully informed
Vertebral Body Hemangioma Visualized on Tc-99m HMPAO-Labeled Leukocyte SPECT/CT
Authors: Jonathan R. Dillman, Richard K. J. Brown, Kirk A. Frey, Douglas J. Quint
Journal: Clinical Nuclear Medicine (2008)

Tc-99m hexamethylpropyleneamine oxime (HMPAO)-labeled leukocyte scintigraphy is commonly used to evaluate suspected occult acute and chronic pyogenic infectious processes. With the advent of fused single photon emission computed tomography (SPECT)/computed tomography (CT) imaging, areas of scintigraphic abnormality can be immediately and unequivocally anatomically localized. Osteomyelitis of the spine, when present, can demonstrate either focally increased or decreased labeled leukocyte uptake. We present a case of focally decreased labeled leukocyte uptake within the lumbar spine that scintigraphically mimicked osteomyelitis but was determined to represent a vertebral body hemangioma on fused SPECT/CT imaging.
Interleukin-2-induced lung injury. The role of complement.
Authors: R Rabinovici, M D Sofronski, P Borboroglu, A M Spirig, L M Hillegas, J Levine, J Vernick, S M Scesney, N Feuerstein, G Feuerstein
Journal: Circulation Research (1994)

Pulmonary edema and sepsis-like syndrome are grave complications of interleukin-2 (IL-2) therapy. Recent animal studies have suggested IL-2-induced microvascular injury as the underlying mechanism. Since complement factors have been shown to mediate increased vascular permeability in diverse conditions that lead to pulmonary injury and recombinant human IL-2 is known to activate the complement system in patients undergoing IL-2 therapy, we hypothesized that complement factors play a pivotal role in the development of increased vascular permeability after IL-2 treatment. To test this hypothesis, we evaluated the capacity of recombinant soluble human complement receptor type 1 (sCR1, BRL 55730), a new highly specific complement inhibitor, to attenuate IL-2-induced lung injury in the rat. Recombinant human IL-2 (intravenously for 60 minutes) at 10(6) U per rat (n = 4) elevated lung water content (37 +/- 6%, P &lt; .05), myeloperoxidase activity (162 +/- 49%, P &lt; .05), and serum thromboxane B2 (30 +/- 1 pg/100 microL, P &lt; .01) and had no effect on serum tumor necrosis factor-alpha sCR-1 at 30 mg/kg (n = 5), but not at 10 mg/kg (n = 6), attenuated the elevation of lung water content (18 +/- 2%, P &lt; .05) and myeloperoxidase activity (42 +/- 9%, P &lt; .05) but failed to alter serum thromboxane B2 response to IL-2. These data suggest the involvement of complement in the pathogenesis of IL-2-induced pulmonary microvascular injury and point to the potential therapeutic capacity of complement inhibitors in combating this toxic effect of IL-2 therapy.
Incorrect Decapeptide Sequence in the Article by Lauvsnes et al (Arthritis Rheum, December 2013)
Authors: Maria B. Lauvsnes, Stian S. Maroni, Simone Appenzeller, Mona K. Beyer, Ole J. Greve, Jan T. Kvaløy, Erna Harboe, Lasse G. Gøransson, Anne B. Tjensvoll, Roald Omdal
Journal: Arthritis & Rheumatology (2014)

In the article by Lauvsnes et al in the December 2013 issue of Arthritis & Rheumatism (pages 3209–3217), a character was missing from the reported sequence of the synthetic decapeptide mentioned in the “Anti-NR2 antibodies in blood” and “Anti-NR2 antibodies in CSF” paragraphs of Patients and Methods. The correct sequence is DWEYSVWLSN. We regret the errors.
Some factors affecting cerebral tissue saturation during obstructive sleep apnoea
Authors: A. Valipour, A.D. McGown, H. Makker, C. O'Sullivan, S.G. Spiro
Journal: European Respiratory Journal (2002)

Measurement of cerebral tissue saturation during obstructive sleep apnoea (OSA) may provide additional information to conventional peripheral oxygen saturation. Thirteen subjects with OSA (mean apnoea/hypopnoea index 65.7±27.9) were monitored using full polysomnography and monitoring of near-infrared cerebral tissue oxygenation index (TOI). One-thousand and thirty-six apnoeas and hypopnoeas were analysed, in terms of duration, sleep stage, arterial oxygen saturation ( S a,O 2 ) dip, minimum S a,O 2 , TOI dip and minimum TOI. Cerebral TOI is a measure of cerebral tissue saturation of haemoglobin with oxygen, calculated using near-infrared spatially resolved spectroscopy, which has been shown to have a high specificity for intracranial changes. Decreases in cerebral oxygenation were observed during apnoeas and hypopnoeas. Baseline TOI ranged from 50.1–73.0% and mean apnoea/hypopnoea related TOI dips ranged from 1.43–6.85%. Mean S a,O 2 dips varied from 3.8–21.7%. In regression analysis, factors significantly predicting the magnitude of the TOI dip were S a,O 2 dip, minimum S a,O 2 , apnoea duration and rapid eye movement sleep stage. The effect of apnoea duration and sleep stage remained significant after S a,O 2 was included in the regression equation. Near-infrared spectroscopy provides a noninvasive technique for monitoring cerebral tissue saturation during obstructive sleep apnoea.
Management of urinary tract infections in children: Authors' reply
Authors: M. G Coulthard
Journal: BMJ (2003)

EDITOR—Jadresic is concerned that our nurse led study of general practice management of children with urine infection resulted in many children undergoing imaging but few kidney scars being found. Sandell also advocates investigating fewer children, as he believes serious disease is rare.

Their conclusions are misleading, however, because they ignore the …
Psoriasis Severity and the Prevalence of Major Medical Comorbidity
Authors: Howa Yeung, Junko Takeshita, Nehal N. Mehta, Stephen E. Kimmel, Alexis Ogdie, David J. Margolis, Daniel B. Shin, Rosemary Attor, Andrea B. Troxel, Joel M. Gelfand
Journal: JAMA Dermatology (2013)

Despite the growing literature on comorbidity risks in psoriasis, there remains a critical knowledge gap on the degree to which objectively measured psoriasis severity may affect the prevalence of major medical comorbidity.OBJECTIVE To examine the prevalence of major medical comorbidity in patients with mild, moderate, or severe psoriasis, classified objectively based on body surface area involvement, compared with that in patients without psoriasis.DESIGN, SETTING, AND PARTICIPANTS Population-based cross-sectional study of patient data from United Kingdom-based electronic medical records; analysis included 9035 patients aged 25 to 64 years with psoriasis and 90 350 age-and practice-matched patients without psoriasis. MAIN OUTCOMES AND MEASURES Prevalence of major medical comorbidity included in the Charlson comorbidity index.RESULTS Among patients with psoriasis, 51.8%, 35.8%, and 12.4%, respectively, had mild, moderate, or severe disease based on body surface area criteria.The mean Charlson comorbidity index was increasingly higher in patients with mild (0.375 vs 0.347), moderate (0.398 vs 0.342), or severe psoriasis (0.450 vs 0.348) (each P < .05).Psoriasis overall was associated with higher prevalence of chronic pulmonary disease (adjusted odds ratio, 1.08; 95% CI, 1.02-1.15),diabetes mellitus (1.22; 1.11-1.35),diabetes with systemic complications (1.34; 1.11-1.62),mild liver disease (1.41; 1.12-1.76),myocardial infarction (1.34; 1.07-1.69),peptic ulcer disease (1.27; 1.03-1.58),peripheral vascular disease (1.38; 1.07-1.77),renal disease (1.28; 1.11-1.48),and rheumatologic disease (2.04; 1.71-2.42).Trend analysis revealed significant associations between psoriasis severity and each of the above comorbid diseases (each P < .05). CONCLUSIONS AND RELEVANCEThe burdens of overall medical comorbidity and of specific comorbid diseases increase with increasing disease severity among patients with psoriasis.Physicians should be aware of these associations in providing comprehensive care to patients with psoriasis, especially those presenting with more severe disease.
Routine Angioplasty after Fibrinolysis — How Early Should “Early” Be?
Authors: Freek W.A. Verheugt
Journal: New England Journal of Medicine (2009)

Reperfusion therapy has represented a great leap forward in the management of myocardial infarction with ST-segment elevation. Its goal is early and complete recanalization of the infarct-related artery to salvage myocardium and improve both early and late clinical outcomes. Complete reperfusion can be achieved with either fibrinolysis or primary percutaneous coronary intervention (PCI), but with primary PCI the success rate is higher than 90%, whereas current fibrinolytic therapy leads to full reperfusion in only 50 to 55% of recipients. Primary PCI, therefore, looks like the most appropriate reperfusion tool, but there are substantial logistic restrictions associated with it. The door-to-balloon . . .