tbuckley/cabot-search huggingface dataset:
A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer
Authors: Stephan Braun, Florian D. Vogl, Bjørn Naume, Wolfgang Janni, Michael P. Osborne, R. Charles Coombes, Günter Schlimok, Ingo J. Diel, Bernd Gerber, Gerhard Gebauer, Jean-Yves Pierga, Christian Marth, Daniel Oruzio, Gro Wiedswang, Erich-Franz Solomayer, Günther Kundt, Barbara Strobl, Tanja Fehm, George Y.C. Wong, Judith Bliss, Anne Vincent-Salomon, Klaus Pantel
Journal: New England Journal of Medicine (2005)

We assessed the prognostic significance of the presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis.
Psychosocial Crisis in Diabetic Renal Failure
Authors: John A D'Elia, Suzanne Piening, Antoine Kaldany, Charlene Malarick, Kathy Unger, Susan Ice, Rev Raymond B Anderson, Donald G Miller, Andrew P Lundin
Journal: Diabetes Care (1981)

Twenty-nine diabetic renal failure patients suffered a psychosocial crisis at the time when chronic dialysis or renal transplantation was required. These patients could be classified into groups as to the impact of the crisis in terms of participation in life-support therapy. Group 1 consisted of potentially lethal mechanism (9 patients): discontinued dialysis (5); refused to start dialysis (3); overt act to cause personal harm (1). Group 2 contained probably nonlethal mechanism (11 patients): threatened to discontinue dialysis or to never start dialysis if not given a chance for a transplant (5); threatened to discontinue dialysis or to never start dialysis (5); threatened to cause personal harm (1). Group 3 consisted of a combination of mechanisms (9 patients): with drug abuse (4); without drug abuse (5). Important similarities between the groups were easier to document than were subtle differences in the kinds of options in family and employment relationships; in the degree of objective and subjective handicap due to impaired vision; in the level of expectation and/or disappointment following renal transplantation; and in the capacity to cope with changing personal relationships produced by the complications of diabetes.
ABSORPTION AND ACTION SPECTRA STUDIES ON BITHIONOL AND HALOGENATED SALICYLANILIDE PHOTOSENSITIVITY*
Authors: D. J. CRIPPST, T. ENTA
Journal: British Journal of Dermatology (1970)

Journal Article ABSORPTION AND ACTION SPECTRA STUDIES ON BITHIONOL AND HALOGENATED SALICYLANILIDE PHOTOSENSITIVITY Get access D. J. CRIPPST, D. J. CRIPPST Section of Dermatology, University of Wisconsin Medical Center, Madison, Wisconsin Search for other works by this author on: Oxford Academic Google Scholar T. ENTA T. ENTA Section of Dermatology, University of Wisconsin Medical Center, Madison, Wisconsin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 3, 1 March 1970, Pages 230–242, https://doi.org/10.1111/j.1365-2133.1970.tb12430.x Published: 01 March 1970 Article history Accepted: 08 June 1969 Published: 01 March 1970
Graphology and the Physician
Authors: K. W. Thompson
Journal: JAMA (1965)

<h3>To the Editor:—</h3> In the August 2 issue ofThe Journal(<b>193</b>:349) Dr. John K. Lattimer included in his report on the<i>Autopsy on Abraham Lincoln</i>, facsimiles of four pages of notes written by Dr. Robert King Stone, the family physician of President Lincoln, and comments on Dr. Stone's handwriting. I would like to discuss this handwriting and Dr. Lattimer's brief statement about it. One of the neglected subjects of medical science is the study of handwriting as it relates to the personality and culture of the writer. Unfortunately, graphology has not achieved a satisfactory scientific status in the United States because of its set-back by a few research studies performed at a time when methods were less adequate than they are now. Nevertheless, knowledge has been carried forward by a few dedicated workers, and using present methods much information can be obtained about a writer through an analysis
Postmenopausal Hormones and Glycemic Effects
Authors: Aidan McElduff
Journal: Annals of Internal Medicine (2003)

Letters16 December 2003Postmenopausal Hormones and Glycemic EffectsAidan McElduff, MBBS, PhD, FRACPAidan McElduff, MBBS, PhD, FRACPFrom University of Sydney, Sydney 2066, Australia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-12-200312160-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Does Kanaya and colleagues' study (1) on the glycemic effects of postmenopausal HRT establish that combined HRT prevents diabetes? Diabetes mellitus is diagnosed by the presence of hyperglycemia in the fasting state or at 2 hours after a 75-g glucose challenge (glucose tolerance test). Kanaya and colleagues quoted the Postmenopausal Estrogen/Progestin Interventions (PEPI) study, which showed that combined HRT lowered fasting glucose levels but increased 2-hour postchallenge levels. The authors then examined the effect of HRT on the occurrence of diabetes diagnosed only by fasting glucose level. As expected, given the effect of combined HRT on fasting ...Reference1. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, . Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2003;138:1-9. [PMID: 12513038] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Sydney, Sydney 2066, Australia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGlycemic Effects of Postmenopausal Hormone Therapy: The Heart and Estrogen/progestin Replacement Study: A Randomized, Double-Blind, Placebo-Controlled Trial Alka M. Kanaya , David Herrington , Eric Vittinghoff , Feng Lin , Deborah Grady , Vera Bittner , Jane A. Cauley , and Elizabeth Barrett-Connor Postmenopausal Hormones and Glycemic Effects Alka M. Kanaya , David Herrington , and Elizabeth Barrett-Connor Postmenopausal Hormones and Glycemic Effects John V.L. Sheffield and Eric B. Larson Postmenopausal Hormones and Glycemic Effects John P. Girod and Daniel J. Brotman Metrics 16 December 2003Volume 139, Issue 12Page: 1043-1044KeywordsDiabetes mellitusDiabetes preventionEstrogensGlucoseGlucose toleranceGlucose tolerance testsHormonesHyperglycemia ePublished: 16 December 2003 Issue Published: 16 December 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Health Effects of Involuntary Smoking
Authors: Jonathan E. Fielding, Kenneth J. Phenow
Journal: New England Journal of Medicine (1988)

ALTHOUGH each year since 1964 the Surgeon General has identified smoking as the single most important cause of preventable mortality, of late attention has been focused increasingly on the health effects of involuntary, or passive, smoking. When this topic was first raised in the 1972 Report of the Surgeon General,1 only a handful of studies addressed the issue. In 1979, the encyclopedic report on cancer2 devoted a chapter to passive smoking. The 1984 report on chronic obstructive lung disease3 devoted more attention to passive smoking, on the basis of studies suggesting that nonsmokers who were exposed to spouses who . . .
Temporal Trends in Recording of Diabetes on Death Certificates
Authors: Laura N. McEwen, Andrew J. Karter, J. David Curb, David G. Marrero, Jesse C. Crosson, William H. Herman
Journal: Diabetes Care (2011)

OBJECTIVE To determine the frequency that diabetes is reported on death certificates of decedents with known diabetes and describe trends in reporting over 8 years. RESEARCH DESIGN AND METHODS Data were obtained from 11,927 participants with diabetes who were enrolled in Translating Research into Action for Diabetes, a multicenter prospective observational study of diabetes care in managed care. Data on decedents (N = 2,261) were obtained from the National Death Index from 1 January 2000 through 31 December 2007. The primary dependent variables were the presence of the ICD-10 codes for diabetes listed anywhere on the death certificate or as the underlying cause of death. RESULTS Diabetes was recorded on 41% of death certificates and as the underlying cause of death for 13% of decedents with diabetes. Diabetes was significantly more likely to be reported on the death certificate of decedents dying of cardiovascular disease than all other causes. There was a statistically significant trend of increased reporting of diabetes as the underlying cause of death over time (P &amp;lt; 0.001), which persisted after controlling for duration of diabetes at death. The increase in reporting of diabetes as the underlying cause of death was associated with a decrease in the reporting of cardiovascular disease as the underlying cause of death (P &amp;lt; 0.001). CONCLUSIONS Death certificates continue to underestimate the prevalence of diabetes among decedents. The increase in reporting of diabetes as the underlying cause of death over the past 8 years will likely impact estimates of the burden of diabetes in the U.S.
A NEW AMPULE NEEDLE
Authors: George A. Clark
Journal: JAMA (1930)

During the last ten years, the use of serum has increased tremendously in the treatment of many diseases. The different biologic houses place on the market ampules varying in size from 1 cc. to 20 cc. A large number of these ampules are rubber capped and the contents must be aspirated by a syringe and needle. It is undoubtedly an awkward procedure. One must fill the syringe with air and work the plunger back and forth in order to withdraw the required amount for the injection. This usually produces a foam in the barrel of the syringe which is annoying.  I have been in the habit of injecting a small hypodermic needle into the rubber cap at the same time that I wish to withdraw the fluid by the syringe and needle. This second hypodermic needle acts as an air vent. The necessary amount of fluid can then be withdrawn
Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7
Authors: Andrea Vergani, Sara Tezza, Francesca D’Addio, Carmen Fotino, Kaifeng Liu, Monika Niewczas, Roberto Bassi, R. Damaris Molano, Sonja Kleffel, Alessandra Petrelli, Antonio Soleti, Enrico Ammirati, Maria Frigerio, Gary Visner, Fabio Grassi, Maria E. Ferrero, Domenico Corradi, Reza Abdi, Camillo Ricordi, Mohamed H. Sayegh, Antonello Pileggi, Paolo Fiorina
Journal: Circulation (2012)

Heart transplantation is a lifesaving procedure for patients with end-stage heart failure. Despite much effort and advances in the field, current immunosuppressive regimens are still associated with poor long-term cardiac allograft outcomes, and with the development of complications, including infections and malignancies, as well. The development of a novel, short-term, and effective immunomodulatory protocol will thus be an important achievement. The purine ATP, released during cell damage/activation, is sensed by the ionotropic purinergic receptor P2X7 (P2X7R) on lymphocytes and regulates T-cell activation. Novel clinical-grade P2X7R inhibitors are available, rendering the targeting of P2X7R a potential therapy in cardiac transplantation.We analyzed P2X7R expression in patients and mice and P2X7R targeting in murine recipients in the context of cardiac transplantation. Our data demonstrate that P2X7R is specifically upregulated in graft-infiltrating lymphocytes in cardiac-transplanted humans and mice. Short-term P2X7R targeting with periodate-oxidized ATP promotes long-term cardiac transplant survival in 80% of murine recipients of a fully mismatched allograft. Long-term survival of cardiac transplants was associated with reduced T-cell activation, T-helper cell 1/T-helper cell 17 differentiation, and inhibition of STAT3 phosphorylation in T cells, thus leading to a reduced transplant infiltrate and coronaropathy. In vitro genetic upregulation of the P2X7R pathway was also shown to stimulate T-helper cell 1/T-helper cell 17 cell generation. Finally, P2X7R targeting halted the progression of coronaropathy in a murine model of chronic rejection as well.P2X7R targeting is a novel clinically relevant strategy to prolong cardiac transplant survival.
Subcellular compartmentation of creatine kinase isoenzymes in guinea pig heart
Authors: E. A. OGUNRO, T. J. PETERS, D. J. HEARSE
Journal: Cardiovascular Research (1977)

Journal Article Subcellular compartmentation of creatine kinase isoenzymes in guinea pig heart Get access E. A. OGUNRO, E. A. OGUNRO From the Cardiovascular Research Unit and Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, and the Myocardial Metabolism Research Laboratories, The Rayne Institute, St Thomas' Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar T. J. PETERS, T. J. PETERS From the Cardiovascular Research Unit and Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, and the Myocardial Metabolism Research Laboratories, The Rayne Institute, St Thomas' Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar D. J. HEARSE D. J. HEARSE 2 From the Cardiovascular Research Unit and Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, and the Myocardial Metabolism Research Laboratories, The Rayne Institute, St Thomas' Hospital, London 2Address for correspondence and reprints: Dr D. J. Hearse, Myocardial Metabolism Research Laboratories, The Rayne Institute, St Thomas' Hospital, London SE1 7EH. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 11, Issue 3, May 1977, Pages 250–259, https://doi.org/10.1093/cvr/11.3.250 Published: 01 May 1977
Abstract 17313: Bedside Ultrasound for Serial Assessment of Central Venous Pressure in Patients with Volume Overload
Authors: Jonathan E Leeman, Marc A Simon, Madhurmeet Singh, James R Johnston, John J Pacella
Journal: Circulation (2011)

Background: Using bedside ultrasound, we have previously shown that a greater than 17% increase in internal jugular vein (IJ) cross sectional area (CSA) during Valsalva rules out elevated right atrial pressure (RAP &gt; 12mmHg, NPV 94%). This occurs because venous compliance increases nonlinearly with increasing pressure. Here, we sought to validate this US test in the first longitudinal study of patients undergoing acute volume removal during hemodialysis (HD) as well as patients undergoing diuresis for acute decompensated heart failure (ADHF). Methods: Images of the right IJ were captured using portable bedside US before and during the strain phase of a standardized Valsalva maneuver (Fig 1) on hospitalized patients who were either admitted for ADHF or undergoing HD. For HD patients (n=11), percent change in IJ CSA with Valsalva (ΔCSA) was assessed both before and after HD treatment. For ADHF patients (n=37), ΔCSA was measured both at admission and discharge. Results: For HD patients, analysis of US images detected elevated filling pressures (ΔCSA &lt;17%) in 11 of the patients studied. In these subjects, a mean fluid volume of 1.8L was removed and 10 subjects demonstrated an increased ΔCSA after HD (ΔCSA increase of 45 ± 40%, p17% indicating restoration of normal filling pressures. Of the 37 ADHF patients studied with elevated filling pressures at admission (ΔCSA &lt;17%), 27 demonstrated euvolemia after diuresis (ΔCSA increase of 57 ± 157%, p&lt;0.01) and an average length of stay of 7.8 days. Conclusion: US of the IJ can be used to examine intravascular volume status in response to fluid changes that occur over the course of hours (HD) or days (ADHF). This simple bedside technique could be utilized for monitoring volume changes, both acutely and longer term, to guide volume management and overcome some of the difficulties associated with traditional visual assessment of jugular venous pulsations.
Primary Malignant Melanoma of the Esophagus Presenting with Massive Hematemesis
Authors: H. Yoshikane, T. Suzuki, N. Yoshioka, Y. Ogawa, E. Hamajima, N. Hasegawa, S. Nakamura, Y. Kamiya
Journal: Endoscopy (1995)

A 66-year-old Japanese man was admitted to our hospital, presenting with massive hematemesis. Emergency endoscopy revealed a bleeding tumor at the esophagogastric junction. The endoscopic appearance of the tumor was that of a Borrmann 2-like tumor, with a brownish-black discoloration. Bioptic histology confirmed the diagnosis of malignant melanoma. Atypical melanocytes with junctional changes were also found at a small pigmented patch in the lower esophagus, separate from the gross tumor. Melanocytosis was noted in the adjacent esophageal epithelium in the resection specimen following surgery. No primary lesion was found elsewhere, even in the patient's skin. These pathologic findings support the possibility of multicentric occurrence of malignant melanoma in esophageal melanocytosis. The patient is alive 11 months later, with multiple liver metastases. Massive hematemesis is an unusual presentation of primary malignant melanoma of the esophagus.
Cytokine regulation of immunoglobulin secretion by neonatal lymphocytes.
Authors: J B Splawski, P E Lipsky
Journal: Journal of Clinical Investigation (1991)

In contrast to adult lymphocytes, neonatal lymphocytes secrete minimal amounts of Ig in response to stimulation with immobilized MAb to CD3. This deficiency could be overcome by the addition of supplemental IL-2, IL-4, or IL-6, resulting in the secretion of all Ig isotypes. There were no major differences in the distribution of Ig isotypes secreted in response to the cytokines alone or in combination. The Ig secreted in response to IL-4 or IL-6 was inhibited by MAb to CD25, suggesting that the effects of IL-4 and IL-6 were dependent on IL-2. Stimulation of neonatal lymphocytes with anti-CD3 was sufficient to induce expression of IL-2 receptors (CD25) on both T and B cells. IL-4 exerted direct effects on neonatal T cells by increasing IL-2 production and promoting IL-6 production by anti-CD3-stimulated neonatal lymphocytes. Antibody to IL-4 or IL-6 did not inhibit Ig secretion in response to IL-2 and antibody to IL-6 did not consistently inhibit Ig secretion in response to IL-4. Finally, in the presence of cyclosporin, anti-CD3-stimulated neonatal lymphocytes secreted Ig only with the combination of IL-2 and IL-4. These results have delineated unique, but not Ig isotype-specific, effects of cytokines in supporting Ig secretion by anti-CD3-stimulated neonatal lymphocytes. Deficient production of these cytokines is likely to contribute to the decreased capacity of neonatal lymphocytes to generate an Ig response.
Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma
Authors: Maymi Kato, Koichi Ohshima, Masahiro Mizuno, Masahisa Kyogoku, Keiko Hashikawa, Yoshiki Tokura, Yoshiki Miyachi, Kenji Kabashima
Journal: Journal of the American Academy of Dermatology (2009)
In Vivo Treatment of <i>Propionibacterium acnes</i> Infection with Liposomal Lauric Acids
Authors: Dissaya Pornpattananangkul, Victoria Fu, Soracha Thamphiwatana, Li Zhang, Michael Chen, James Vecchio, Weiwei Gao, Chun‐Ming Huang, Liangfang Zhang
Journal: Advanced Healthcare Materials (2013)

Abstract Propionibacterium acnes (P. acnes ) is a Gram‐positive bacterium strongly associated with acne infection. While many antimicrobial agents have been used in clinic to treat acne infection by targeting P. acnes , these existing anti‐acne agents usually produce considerable side effects. Herein, the development and evaluation of liposomal lauric acids (LipoLA) is reported as a new, effective and safe therapeutic agent for the treatment of acne infection. By incorporating lauric acids into the lipid bilayer of liposomes, it is observed that the resulting LipoLA readily fuse with bacterial membranes, causing effective killing of P. acnes by disrupting bacterial membrane structures. Using a mouse ear model, we demonstrated that the bactericidal property of LipoLA against P. acne is well preserved at physiological conditions. Topically applying LipoLA in a gel form onto the infectious sites leads to eradication of P. acnes bacteria in vivo. Further skin toxicity studies show that LipoLA does not induce acute toxicity to normal mouse skin, while benzoyl peroxide and salicylic acid, the two most popular over‐the‐counter acne medications, generate moderate to severe skin irritation within 24 h. These results suggest that LipoLA hold a high therapeutic potential for the treatment of acne infection and other P. acnes related diseases.
Genus human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study
Authors: M. R. Karagas, T. Waterboer, Z. Li, H. H. Nelson, K. M. Michael, J. N. B. Bavinck, A. E. Perry, S. K. Spencer, J. Daling, A. C. Green, M. Pawlita
Journal: BMJ (2010)

<b>Objective</b> To investigate the association between genus β human papillomaviruses and the incidence of non-melanocytic skin cancer in the general population. <b>Design</b> Population based case-control study. <b>Setting</b> New Hampshire, USA. <b>Participants</b> 2366 skin cancer cases and controls from the general population aged 25 to 74 years (663 squamous cell carcinoma, 898 basal cell carcinoma, 805 controls), with plasma samples tested for L1 antibodies to 16 genus β human papillomaviruses by multiplex serology. <b>Main outcome measures</b> Odds ratios for squamous cell carcinoma and basal cell carcinoma associated with seropositivity to β human papillomaviruses. <b>Results</b> Squamous cell carcinoma, but not basal cell carcinoma, cases had a higher prevalence of each of the individual β human papillomaviruses assayed compared with controls. The odds ratios for squamous cell carcinoma increased with the number of β types positive (odds ratio for one type positive 0.99 (95% confidence interval 0.74 to 1.33); two to three types positive 1.44 (1.03 to 2.01); four to eight types positive 1.51 (1.03 to 2.20); more than eight types positive 1.71 (1.12 to 2.62); P for trend (categorical)&lt;0.001; P for trend (continuous)=0.003). With limited statistical power, the association was stronger among long term users of systemic glucocorticoids (odds ratio 3.21, 1.22 to 8.44) than among non-users (1.23, 0.97 to 1.55). <b>Conclusions</b> These findings support a relation between genus β human papillomavirus infection and the incidence of squamous cell carcinoma of the skin in the general population, as well as potential enhancement of risk by immunosuppression.