Plasma Volume and Renal Circulatory Function in Cirrhosis
Authors: RANDOLPH M. MCCLOY
Journal: Annals of Internal Medicine (1967)

Article1 February 1967Plasma Volume and Renal Circulatory Function in CirrhosisRANDOLPH M. MCCLOY, M.D., WILLIAM P. BALDUS, M.D., W. NEWLON TAUXE, M.D., W. H. J. SUMMERSKILL, M.D., F.A.C.P.RANDOLPH M. MCCLOY, M.D.Search for more papers by this author, WILLIAM P. BALDUS, M.D.Search for more papers by this author, W. NEWLON TAUXE, M.D.Search for more papers by this author, W. H. J. SUMMERSKILL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-2-307 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiminutions in plasma volume (1-6) or effective extracellular fluid volume (7-12) have been proposed as explanations for renal circulatory failure in patients with cirrhosis. Hori, Austen, and McDermott (4) and Lieberman and Reynolds (6) attributed the decrease in glomerular filtration rate to hypovolemia, and Vesin (1) believed that plasma volume is never increased and is usually low in such patients. In a later article with Traverso and colleagues (2) that described eight patients with low creatinine clearances, Vesin did not indicate whether the plasma volumes reported were normal.However, when plasma volume was measured in patients with cirrhosis (13-19), including...References1. VESIN P: Late functional renal failure in cirrhosis with ascites: pathophysiology, diagnosis and treatment, in Aktuelle Probleme der Hepatologie, edited by MARTINI, G. A. Georg Thieme Verlag, Stuttgart, Germany, 1962, pp. 98-109. Google Scholar2. TRAVERSOVESINCOMBRISSONBESSONCATTAN HPAPR: Charge intraveineuse d'albumine dans les cirrhoses ascitiques. Etude biologique. Sem. Hôp. Paris 40: 17, 1964. MedlineGoogle Scholar3. 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Author, Article, and Disclosure InformationAffiliations: Rochester, MinnesotaFrom the Gastrointestinal Research Unit and the Sections of Medicine and Clinical Pathology, Mayo Clinic and Mayo Foundation, and the Department of Gastroenterology, Mayo Graduate School of Medicine, Rochester, Minn.This study was supported in part by research grant AM-06908, National Institutes of Health, Bethesda, Md.At the time of this study Dr. McCloy was the recipient of grant AM-5259, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Mayo Clinic, 200 First St. SW, Rochester, Minn. 55901. 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SCHROEDER, M.D., PATRICIA J. NUMANN, M.D., BRUCE E. CHAMBERLAIN, M.D.Normal sulfobromophthalein retention in established liver diseaseTransplantation of Cadaveric Kidneys from Patients with Hepatorenal SyndromeRenal Failure in Cirrhosis—Role of Plasma VolumeSOLOMON PAPPER, M.D., CARLOS A. VAAMONDE, M.D.Effects of Changing Plasma Volume, Serum Albumin Concentration, and Plasma Osmolality on Renal Function in Cirrhosis 1 February 1967Volume 66, Issue 2Page: 307-311KeywordsBlood plasmaCirrhosisClinical pathologyCreatinineGlomerular filtration rateGraduate medical educationPlasma volumeRenal circulationRenal failureResearch grants Issue Published: 1 February 1967 PDF DownloadLoading ...