ACTH, CORTISONE AND HYPERSENSITIVE DISEASE STATES
Authors: MILTON S. SACKS
Journal: Annals of Internal Medicine (1952)

Editorial1 March 1952ACTH, CORTISONE AND HYPERSENSITIVE DISEASE STATESMILTON S. SACKSMILTON S. SACKSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-3-911 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent studies with ACTH and cortisone have demonstrated remarkable, albeit often transitory, effects of these hormones upon a large group of diseases of known hypersensitive etiology. These results have encouraged wider exploration of the therapeutic potentialities of the corticoids in diseases of obscure etiology where hypersensitive mechanisms have been suspected, but not proved. The beneficial effects of hormonal therapy in such widely separated entities as acquired hemolytic anemia,1sympathetic ophthalmia,2ulcerative colitis,3and experimental acute disseminated encephalomyelitis,4to name but a few, have aroused renewed interest in a search for common denominators. A brief survey of recent contributions to these...1 DameshekRosenthalSchwartz WMCLI: The treatment of acquired hemolytic anemia with adrenocorticotrophic hormone (ACTH), N. Eng. J. Med. 244: 117, 1951. CrossrefGoogle Scholar2 Thorpe HE: ACTH and cortisone in ocular trauma and in eye surgery, Proc. 2nd Clin. ACTH Conf., 1951, The Blakiston Co., Philadelphia, Vol. 2, p. 340. Google Scholar3 GrayReifensteinBensonYoung SJRWJAJC: Treatment of ulcerative colitis and regional enteritis with ACTH: significance of fecal lysozyme, Arch. Int. Med. 87: 646, 1951. CrossrefGoogle Scholar4 KabatWolfBeger EAAAE: Effect of cortisone on experimental acute disseminated encephalomyelitis, Fed. Proc. 10: 412, 1951. Google Scholar5 Clark I: Effect of cortisone on protein metabolism in the rat as studied with isotopic glycine, Fed. Proc. 9: 161, 1950. Google Scholar6 Fischel E: Discussion, ACTH and Antibodies, Proc. 2nd Clin. ACTH Conference, 1951, The Blakiston Co., Philadelphia, Vol. 1, p. 492. Google Scholar7 Ingle DJ: The biologic properties of cortisone: a review, J. Clin. Endocrinology 10: 1312, 1950. CrossrefGoogle Scholar8 DoughertyWhiteChase TFAJH: Relationship of effects of adrenal cortical secretion on lymphoid tissue and on antibody titer, Proc. Soc. Exper. Biol. and Med. 56: 28, 1944. CrossrefGoogle Scholar9 WedgewoodHawnJaneway RJCVCA: The mechanism of action of ACTH in experimental nephritis due to foreign protein, Proc. 2nd Clin. ACTH Conf., 1951, The Blakiston Co., Philadelphia, Vol. 1, p. 108. Google Scholar10 BjørneboeFischelStoerk MEEHC: The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody, J. Exper. Med. 93: 37, 1951. CrossrefMedlineGoogle Scholar11 GermuthOttinger FGB: Effect of 17-hydroxy-11-dehydrocorticosterone (Compound E) and of ACTH on Arthus reaction and antibody formation in the rabbit, Proc. Soc. Exper. Biol. and Med. 74: 815, 1950. CrossrefMedlineGoogle Scholar12 Fischel EE: The relationship of adrenal cortical activity to immune responses, Bull. N. Y. Acad. Med. 26: 255, 1950. MedlineGoogle Scholar13 GrobSchoenrichWinkenwerderHarvey DEHWCAM: The influence of ACTH on the reactivity of the bronchial tree, skin and secretory glands to specific antigens, histamine and mecholyl in bronchial asthma, Proc. 2nd Clin. ACTH Conf., 1951, The Blakiston Co., Philadelphia, Vol. 1, p. 499. Google Scholar14 Sprague RG: Cortisone and ACTH: a review of certain physiologic effects and their clinical implications, Am. J. Med. 10: 567, 1951. CrossrefMedlineGoogle Scholar15 Ehrich WE: The nature of collagen diseases, Am. Heart J. 43: 121, 1952. CrossrefMedlineGoogle Scholar16 PisciottaGilibertiGreenwaltEngstrom AVJJTJWW: Acute hemolytic anemia in disseminated lupus erythematosus, Am. J. Clin. Path. 21: 1139, 1951. CrossrefMedlineGoogle Scholar17 RantzCregerChoy LAWPSH: Immunologic hyperreactivity in the pathogenesis of rheumatic fever and other diseases, Am. J. Med. 12: 115, 1952. CrossrefGoogle Scholar18 EvansTakahashiDuanePayneLiu RSKRTRCK: Primary thrombocytopenic purpura and acquired hemolytic anemia: evidence for a common etiology, Arch. Int. Med. 87: 48, 1951. CrossrefGoogle Scholar19 HarringtonMinnichHollingsworthMoore WJVJWCV: Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura, J. Lab. and Clin. Med. 38: 1, 1951. MedlineGoogle Scholar20 BethellMeyersMillerBullock FHMCSWH: Effects of ACTH and cortisone on idiopathic thrombocytopenic purpura, Tr. A. Am. Physicians 64: 199, 1951. 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CrossrefGoogle Scholar26 GlaserMerrittTraeger GHHHCH: The effect of pituitary adrenocorticotrophic hormone (ACTH) on multiple sclerosis: a preliminary report, Proc. 2nd Clin. ACTH Conf., 1951, The Blakiston Co., Philadelphia, Vol. II, p. 141. Google Scholar27 McLean JH: Discussion, ACTH and multiple sclerosis, Proc. 2nd Clin. ACTH Conf., 1951, The Blakiston Co., Philadelphia, Vol. I, p. 147. Google Scholar28 Collins RC: Experimental studies on sympathetic ophthalmia, Am. J. Ophth. 32: 1687, 1949. CrossrefMedlineGoogle Scholar29 LawsHoward AWRP: ACTH in sympathetic ophthalmia, Canad. M. A. J. 64: 530, 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie pathogenetische Bedeutung der Allergie für Blut- und Knochenmarksschäden 1 March 1952Volume 36, Issue 3Page: 911-915KeywordsAdrenocorticotropic hormoneEtiologyHormonal therapyHormones Issue Published: 1 March 1952 PDF downloadLoading ...