tbuckley/cabot-search huggingface dataset:
Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis
Authors: Chaoying Hu, Liu Qian, Yi Miao, Qiuyu Huang, Ping Miao, Ping Wang, Qiwen Yu, Hong Nie, Jiying Zhang, Dongyi He, Rong Xu, Xuehua Chen, Bingya Liu, Dongqing Zhang
Journal: Cellular and Molecular Immunology (2011)
New magnetic resonance imaging methods in nephrology
Authors: Jeff L. Zhang, Glen Morrell, Henry Rusinek, Eric E. Sigmund, Hersh Chandarana, Lilach O. Lerman, Pottumarthi V. Prasad, David Niles, Nathan Artz, Sean Fain, Pierre-Hugues Vivier, Alfred K. Cheung, Vivian S. Lee
Journal: Kidney International (2013)
Primary Pulmonary Hypertension in Association with Human T-Cell Lymphotropic Virus Type I in a Hemophiliac
Authors: Toru Suzuki
Journal: Annals of Internal Medicine (1995)

Letters1 September 1995Primary Pulmonary Hypertension in Association with Human T-Cell Lymphotropic Virus Type I in a HemophiliacToru Suzuki, MDToru Suzuki, MDUniversity of Tokyo; Tokyo 153 JapanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-5-199509010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I describe the first known case of primary pulmonary hypertension (PPH) in a hemophiliac with human T-cell lymphotropic virus type I (HTLV-I).A 44-year-old Japanese man with hemophilia A had HTLV-I infection caused by blood transfusions. He experienced aggravating dyspnea on exertion. The physical examination, chest radiograph, and echocardiographic findings suggested pulmonary hypertension. Cardiac catheterization confirmed pulmonary hypertension with near systemic pulmonary artery pressures. Pulmonary capillary wedge pressures were not elevated. No secondary cause of pulmonary hypertension could be found despite extensive testing. The diagnosis of PPH was thus established. Despite transient episodes of aggravation of symptoms, ...References1. Goldsmith GH JR., Bailey, RG, Brettler DB, et al. Primary pulmonary hypertension patients with classic hemophilia. Ann Intern. Med. 1988; 108:797-9. Google Scholar2. Mette SA, Palvesky HI, Pietra GG, et al. Primary pulmonary hypertension in association with human immunodeficiency virus infection: a possiable viral etiology for some forms of hypertensive pulmonary arteriopathy. Am Rev Respir Dis. 1992; 145:1196-200. Google Scholar3. Coplan NL, Shimony RY, Ioachim HL, et al. Primary pulmonary hypertension associated with human immunodeficiency viral infection. Am J Med. 1990; 89:96-9. Google Scholar4. Speich R, Jenni R, Opravil M, Pfab M, Russi FW. Primary pulmonary hypertension in HIV infection. Chest. 1991; 100: 1268-7. Google Scholar5. Nakamura S, Salahuddin SZ, Biberfeld P, et al. Kaposi's sarcoma cells: long-term culture with growth factor from retrovirus- infected CD4+) T cells. Science. 1988; 242:426-30. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Tokyo; Tokyo 153 Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByViral infection and pulmonary hypertension: is there an association?Hypertension artérielle pulmonaire primitive et infection par le rétrovirus HTLV-1 au stade de leucémie-lymphome T de l’adulte 1 September 1995Volume 123, Issue 5Page: 394KeywordsHIVHIV infectionsKaposi sarcomaPathogenesisPulmonary arteriesPulmonary capillary wedgePulmonary hypertensionRetrovirusesT cellsThorax Issue Published: 1 September 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Oral anticoagulants controlled by the British comparative thromboplastin versus low-dose heparin in prophylaxis of deep vein thrombosis
Authors: D A Taberner, L Poller, R W Burslem, J B Jones
Journal: BMJ (1978)

The British comparative thromboplastin (BCT) was used to monitor the effectiveness of oral anticoagulants in preventing deep vein thrombosis (DVT) in patients undergoing major gynaecological surgery. All patients were screened for DVT with the use of the <sup>125</sup>I-fibrinogen scan. One hundred and forty-five patients aged 40 years or more were randomised into three groups. Group 1 received oral anticoagulant (nicoumalone) treatment, stabilised over five days before surgery and continuing into the second postoperative week. The other patients served as two contrast groups and were managed on a double-blind basis. Group 2 received a subcutaneous low-dose regimen of heparin calcium. Group 3 received subcutaneous saline. Eleven of 48 patients in the saline group, three of 49 patients in the heparin group, and three of 48 patients in the oral anticoagulant group developed DVT as judged by <sup>125</sup>I-fibrinogen scanning. The incidences in groups 1 and 2 were significantly lower than in the saline group. The falls in haemoglobin concentration and incidence of haemorrhage were similar in all three groups. The study showed that oral anticoagulant prophylaxis stabilised preoperatively and low-dose heparin were equally effective in preventing deep vein thrombosis in a moderate-risk group. Immediate preoperative prothrombin ratios of 2·0-2·5 and postoperative ratios of 2·0-4·0 with the BCT gave adequate protection without increased haemorrhagic risk.
Biblical Reason for Forbidding Use of Milk and Meat
Authors: Morris Chamurich
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In reading the several letters inThe Journalanent the above-captioned item, I was surprised that none of them raised the question of<i>Brucella</i>. It must be obvious to anyone who has studied the Bible, who has read the various tracts about the early Holy Land, and who can visualize their degree of sanitation and knowledge of disease that, while they knew nothing of bacteriology, there were those who could associate cause and effect. I merely wish to recall that the goat and sheep were the main sources of milk and meat; that the introduction of kine into the Holy Land is a comparatively recent phenomenon. With this in mind—does it need much medical imagination and acumen to visualize a better culture medium than milk and meat? The early nomads were unsophisticated but they could associate the admixture of milk and meat (both infected with<i>Brucella</i>) with
Women under 25 should be offered screening
Authors: Amanda Herbert, John H F Smith
Journal: BMJ (2007)

There may be several reasons why cervical screening coverage in young women has fallen yet again, including problems with access to appointments with general practitioners, but the new policy not to screen women aged 20-24 can hardly have helped.1 It was announced with the message that screening that age group caused more harm than good, which is unlikely to encourage them to accept their invitations from age 25. Prevalence of carcinoma in situ (CIN3) has increased in women aged 20-24 (figure …
Externally Coated Ureteral Metallic Stents: An Unfavorable Clinical Experience
Authors: George A Barbalias, Evangelos N Liatsikos, Christina Kalogeropoulou, Dimitrios Karnabatidis, Petros Zabakis, Anastasios Athanasopoulos, Petros Perimenis, Dimitrios Siablis
Journal: European Urology (2002)
Herpes simplex antibodies in rheumatoid and control patients.
Authors: C F Stanford, P V Shirodaria, K B Fraser
Journal: Annals of the Rheumatic Diseases (1972)

Heberdent Society 221 twenty rheumatoid subjects with radiologically calcified synovium, we have not found crystals.This was the only instance of concurrence of the two diseases among our 87 cases of chondrocalcinosis.DR.E. B. D. HAMILTON (London) Excluding our patients with haemochromotosis, we have seen about seventy cases of chondrocalcinosis in the last 5 years.This includes three patients with hyperparathyroidism and only one with clinical rheumatoid arthritis; although there were two others with positive tests for rheumatoid factor in low titre.More recently I have reviewed the x rays of 21 patients with hyperparathyroidism, seven of whom had chondrocalcinosis and two had co-existing rheumatoid arthritis.
Abstract A22: Clinical implication of microscopic anthracotic pigment in mediastinal staging of non-small cell lung cancer by endobronchial ultrasound-guided transbronchial needle aspiration
Authors: Young Whan Kim, Young Sik Park, Jinwoo Lee, Sang-Min Lee, Jae-Joon Yim, Sung Koo Han, Jin Chul Pang, Doo Hyun Chung, Seok-Chul Yang
Journal: Clinical Cancer Research (2012)

Abstract Introduction: Microscopic anthracotic pigment is frequently observed in EBUS-TBNA specimen from non-small cell lung cancer, but the clinical interpretation is not known. The aim of this study was to evaluate the clinical implication of microscopic anthracotic pigment in mediastinal staging of non-small cell lung cancer by EBUS-TBNA. Methods: From May 2010 to July 2011, Consecutive potentially operable non-small cell lung cancer patients who underwent EBUS-TBNA for mediastinal staging were recruited in this retrospective study. Results: Total 133 patients, male were 102 (76.7%). Median age was 68. Squamous cell carcinoma (59, 44.4%) and adenocarcinoma (57, 42.9%) were most common. Clinical stages after EBUS-TBNA were as followed; IA (18.8%), IB (17.3%), IIA (6.0%), IIB (9.0%), IIIA (36.8%), IIIB (12.0%). Total 281 mediastinal lymph nodes were sampled by EBUS-TBNA, station 4R (100, 35.8%) and station 7 (86, 30.8%) were most common sites. Malignant lymph nodes were 100 (35.8%). Microscopic anthracotic pigment was observed in 61 (21.7%) lymph nodes, and among them malignant lymph nodes were only 3 (P&amp;lt;0.001). The lymph nodes with microscopic anthracotic pigment were small (9.0 vs. 10.8 mm, P = 0.001) and low SUV on FDG-PET (5.4 vs. 6.7, P = 0.120). In multivariable analysis, microscopic anthracotic pigment was statistically significant associated with benign lymph node (adjusted OR, 14.3; 95% CI, 3.6–57.3; P&amp;lt;0.001). Conclusion: In potentially operable non-small cell lung cancer patients, microscopic anthracotic pigment in endobronchial ultrasound-guided transbronchial needle aspiration specimen was strongly associated with benign mediastinal lymph node.
Chronic subdural haematoma in the elderly
Authors: O M P Jolobe
Journal: Journal of the Royal Society of Medicine (2002)

In the series reported by Dr Asghar and colleagues (June 2002 JRSM1) one-third of the subdural haematomas were in patients receiving antithrombotic therapy. It is a perverse paradox that thromboprophylaxis of age-related disorders such as atrial fibrillation and coronary thrombosis happens to be one of the most significant risk factors for subdural haematoma. Profiling of anticoagulant-related haemorrhagic risk might be of use in identifying those patients for whom alternative strategies, such as cardioversion to sinus rhythm (including drug treatment to prevent relapse), might be preferable for managing embolic risk in disorders such as atrial fibrillation. Profiling for CYP2C0 genetic variants shows promise, in this respect, with documentation of a significant association between warfarin-related haemorrhagic risk (including risk of life-threatening bleeding episodes) and either CYP2C9#2 or CYP2C9#3 polymorphism2, the hepatic microsomal enzyme CYP2C9 being the primary pathway for the metabolism of s-warfarin. For identification of risk of warfarin-related cerebral haemorrhage there is already evidence that there is an important role for profiling of the ApoE genotype, the latter being a marker for cerebral amyloid angiopathy3. In other words, through the use of genetic markers we might be able to identify who metabolizes warfarin abnormally or whose cerebral blood vessels are excessively friable, thereby facilitating the decision between antiarrhythmic therapy and warfarin.
Consistency in Prescription Writing
Authors: Harvey M. Rappaport
Journal: Annals of Internal Medicine (1992)

Letters15 December 1992Consistency in Prescription WritingHarvey M. Rappaport, PhDHarvey M. Rappaport, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-12-1059_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Despite repeated admonitions, patients continue to misread and misinterpret prescription label directions (1). Inability to read or to comprehend does not explain it (2).The simplest way to promote effective communication is to be consistent. Research indicates that a consistent ordering of the elements of prescription label directions would be optimal for comprehension (2). Patients may already have a mental schema for taking medications, and thus "instructions should be better understood when organized to match this knowledge" (3).A recent analysis of over 10 000 computerized signatures of three national chain pharmacies suggests that a simple schema...References1. Kessler D. Communicating with patients about their medications. N Engl J Med. 1992;325:1650-2. CrossrefGoogle Scholar2. MorrellParkPoon RDL. Quality of instructions on prescription drug labels: effects on memory and comprehension in young and old adults. Gerontology. 1989;29:345-54. Google Scholar3. MorrowLeirerAltieriTanke DVPE. Elders' schema for taking medication: implications for instruction design. J Gerontol. 1991;46:378-85. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: College of Pharmacy and Health Sciences Northeast Louisiana University Monroe, LA 71209-0470 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChapter 9. Preventing Prescribing ErrorsState Prescription Label Requirements in the United States 15 December 1992Volume 117, Issue 12Page: 1059-1059KeywordsComputers Issue Published: 15 December 1992 PDF DownloadLoading ...
Are new technologies in infertility treatment always good news?
Authors: R. Hurley
Journal: BMJ (2013)

<b>Aim:</b> To report on visual outcome of patients receiving an intravitreal injection of triamcinolone acetonide for treatment of diffuse diabetic macular oedema. <b>Methods:</b> Prospective, comparative, non-randomised clinical interventional study included 136 patients with diffuse diabetic macular oedema. Patients of the study group (97 eyes) received an intravitreal injection of 20–25 mg of triamcinolone acetonide and no other retinal treatment. Patients of the control group (69 eyes) received focal or panretinal laser treatment if indicated. Mean (standard deviation) follow up was 8.4 (SD 6.0) months (range 1.03–25.2 months). <b>Results:</b> Visual acuity (VA) increased significantly (p&lt;0.001) in the study group with 66 (68%) eyes gaining in VA by at least two Snellen lines. In the control group, VA did not change significantly during the first 4 months of follow up, and decreased significantly (p&lt;0.001) towards the end of the follow up. Difference in change of best VA was significant (p&lt;0.001) between both groups. Correspondingly, the number of patients with VA improvement of two or more Snellen lines and visual loss of two or more Snellen lines, respectively, was significantly (p&lt;0.001) higher and lower, respectively, in the study group. <b>Conclusions:</b> Intravitreal triamcinolone acetonide can temporarily increase VA in some patients with diffuse diabetic macular oedema.
Sounds in the Attic
Authors: Thomas P. Duffy
Journal: New England Journal of Medicine (1993)

An 87-year-old woman who had suffered from chronic constipation came to the emergency room and reported having had abdominal pain for two days. It had begun in the lower abdomen while she was straining with a bowel movement. The pain was constant and later covered the entire abdomen. It increased in severity just before she came to the emergency room. She had no vomiting, diarrhea, melena, chills, or fever.The acute onset of constant abdominal pain makes me worry most about a catastrophic cause, such as a ruptured abdominal aneurysm, but there are obviously numerous other possible causes. . . .
A Dutch window into the development of a two tier healthcare system
Authors: J. V. Guadagno, C. H. Polman
Journal: BMJ (2010)

May we fire a warning shot across the bows—to use a maritime analogy, as is common in the Netherlands—with regard to the renegotiation of contracts in the next phase of the development of independent sector treatment centres? These centres were originally designed (partly) to introduce “apparent” healthy competition into the “inefficient” NHS in England. We say “apparent,” as we would like to emphasise that, contrary to what’s being touted, when it comes to competition it is certainly not a level playing field, to use a more British expression (as they are all level here in the Netherlands). This was brought home to us in a vivid and extreme example while reviewing a patient at the VU Medical Centre in Amsterdam, where private healthcare providers have been in competition for a number of years.

A man with rather benign but definite multiple sclerosis was re-referred to the VU’s multiple sclerosis centre at the request of a private orthopaedic clinic. He had been …
Snow in UK results in cancellation of surgery and outpatient clinics
Authors: L. Eaton
Journal: BMJ (2010)

As Britain struggled to cope with its severest winter for a decade, the NHS warned elderly people to stay home and keep warm—while many non-urgent operations and outpatient clinics were cancelled.

Many hospitals, including those in Oxford, Derby, Exeter, Lewisham, and West Sussex, were forced to cancel outpatient services and lower priority operations as temperatures fell to −13°C in some parts of the country and most areas were covered in thick snow.

“Clinical teams may take the decision to postpone some operations to ensure they can deal with acute and emergency care,” said Mike Farrar, chief executive of the North West Strategic Health Authority. “This is standard procedure. Clinicians will not take this decision lightly, and every effort will be made to reschedule patients’ treatment as soon as possible.” …
Estimating Mean Pulmonary Wedge Pressure in Patients With Chronic Atrial Fibrillation From Transthoracic Doppler Indexes of Mitral and Pulmonary Venous Flow Velocity
Authors: Fabio Chirillo, Maria Cristiana Brunazzi, Mario Barbiero, Davide Giavarina, Mario Pasqualini, Enrico Franceschini-Grisolia, Angelo Cotogni, Antonio Cavarzerani, Giorgio Rigatelli, Paolo Stritoni, Carlo Longhini
Journal: Journal of the American College of Cardiology (1997)
Apheresis in the 1990s.
Authors: E A Robinson
Journal: BMJ (1993)

motivation.5 Alternatively, media publicity or telephone or group contact may provide enough added support."'Likewise, the addition of minimal contact with a therapist seems to enhance the effectiveness of weight loss manuals, but competitive incentives are of particular benefit.9Most intervention studies are short term, focusing on reducing symptoms.Other self direction manuals have broader aims.A "heart manual," for example, covered education, an exercise programme, stress management techniques, and the self treatment of common postoperative psychological problems.At one year follow up the people using the manual were significantly less psychologically disturbed, three times less likely to die, and significantly less likely to have another infarction over the next five years than *those given only stress management training.'0Similar techniques have been used to treat emotional disorders such as depression," 12 anxiety,'314 phobias, 15-17 panics,'8 and eating disorders.'9Patients report being as satisfied with this form of treatment as they are with conventional treatment with a therapist.20The effects of self directed treatment seem to be long lasting, with improvements maintained for several years.'2-"8 2 Teaching the partners of psychiatric patients can also have benefits, increasing their understanding of the illness and strengthening core relationships.22What are the critical elements in successful self directed treatment?Simply giving general advice and information alone is insufficient, although it may lead the reader to seek help.There is plenty of evidence that self directed treatment manuals that teach users key techniques for overcoming problems give more successful results than simple education leaflets.'0 23 24But the order of delivery of components may be important.For example, problem drinkers given strategies for self regulation first and then education had a significantly greater reduction of alcohol intake than a group who received these components in the reverse order.25No differences have yet been found between competing therapeutic rationales such as behavioural and cognitive treatment.10Self directed treatments thus seem to be effective in a variety of conditions.Most of the research so far has tested written materials.Computers have the potential to add "therapeutic interactions" which printed materials cannot,26 and television interventions may also have potential.Self directed interventions are attractive because they allow the possibility of many more patients being treated closer to home and because they allow patients to play an important part in their own treatment.These interventions are unlikely to do specialists out ofa job; instead, integration ofthese approaches into practice will free clinicians' time and skill to focus on the problems of the more severely ill patients.
79 SORAFENIB PLUS TACE FOR THE TREATMENT OF ADVANCED HEPATOCELLULAR CARCINOMA – FINAL RESULTS OF THE SOCRATES TRIAL
Authors: A. Erhardt, F.T. Kolligs, M. Dollinger, E. Schott, H. Wege, M. Bitzer, C. Gog, J. Rädle, M. Schuchmann, C. Walter, D. Blondin, C. Ohmann, D. Häussinger
Journal: Journal of Hepatology (2011)
Anti-tumour necrosis factor therapy modulates ghrelin in patients with severe rheumatoid arthritis
Authors: M A Gonzalez-Gay, M T Garcia-Unzueta, A Berja, T R Vazquez-Rodriguez, C Gonzalez-Juanatey, J M de Matias, J Martin, P H Dessein, J Llorca
Journal: Annals of the Rheumatic Diseases (2008)

The mechanisms involved in inflammation related accelerated atherosclerosis and cardiovascular disease in rheumatoid arthritis (RA) require further study.1

Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, a gastric peptide playing a role in the appetite regulation, possesses anti-inflammatory properties.2 Otero et al showed reduced ghrelin plasma concentrations in patients with RA compared to controls.3

Improvement of insulin resistance in patients with severe disease who started anti-tumour necrosis factor (TNF)α therapy has been described previously.4 Additionally, we have reported a rapid improvement in endothelial dysfunction5 and insulin sensitivity6 following the infusion of the chimeric anti-TNFα/monoclonal antibody/infliximab in patients with RA with severe disease on periodical treatment with this drug. Moreover, inhibition of basal …
ANAESTHESIA IN THE HUMAN SUBJECT WITH KNOWN PERCENTAGES OF CHLOROFORM VAPOUR
Authors: N. H. Alcock
Journal: BMJ (1909)

L 325 organisms set up an arthritis early in the course of the .illnes.Leucocytosis does not seem to be a marked feature; in two acute cases (Pilcher) there was no leucocytosis, whilst in one of our chronic cases there was a slight increase (19,000), but no increase of the polymorphs ; and in an acute case of Wherry's there were 21,000, but he .doesnot mention a differential count.Ag.glutination Test.-In horses McFadyean has obtained ,positive agglutination phenomena in very weak dilutions- :1 in 1,600 as compared with 1 in 300 in healthy animals.Dr. Eyre tells us that in 3 cases recently admitted to Guy's Hospital the serums agglutinated B. mallei in dilu--tions of 1 in 100.In our Case ii no definite results could be -obtained, and various observers have obtained different results; so at present the value of this diagnostic