tbuckley/cabot-search huggingface dataset:
Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review
Authors: Anton Sculean, Dimitris Nikolidakis, George Nikou, Aleksandar Ivanovic, Iain L. C. Chapple, Andreas Stavropoulos
Journal: Periodontology 2000 (2015)

Abstract Intrabony periodontal defects are a frequent complication of periodontitis and, if left untreated, may negatively affect long‐term tooth prognosis. The optimal outcome of treatment in intrabony defects is considered to be the absence of bleeding on probing, the presence of shallow pockets associated with periodontal regeneration (i.e. formation of new root cementum with functionally orientated inserting periodontal ligament fibers connected to new alveolar bone) and no soft‐tissue recession. A plethora of different surgical techniques, often including implantation of various types of bone graft and/or bone substitutes, root surface demineralization, guided tissue regeneration, growth and differentiation factors, enamel matrix proteins or various combinations thereof, have been employed to achieve periodontal regeneration. Despite positive observations in animal models and successful outcomes reported for many of the available regenerative techniques and materials in patients, including histologic reports, robust information on the degree to which reported clinical improvements reflect true periodontal regeneration does not exist. Thus, the aim of this review was to summarize, in a systematic manner, the available histologic evidence on the effect of reconstructive periodontal surgery using various types of biomaterials to enhance periodontal wound healing/regeneration in human intrabony defects. In addition, the inherent problems associated with performing human histologic studies and in interpreting the results, as well as certain ethical considerations, are discussed. The results of the present systematic review indicate that periodontal regeneration in human intrabony defects can be achieved to a variable extent using a range of methods and materials. Periodontal regeneration has been observed following the use of a variety of bone grafts and substitutes, guided tissue regeneration, biological factors and combinations thereof. Combination approaches appear to provide the best outcomes, whilst implantation of alloplastic material alone demonstrated limited, to no, periodontal regeneration.
FRACTURE OF BOTH CLAVICLES.
Authors: SCHUYLER W. HAMMOND
Journal: JAMA (1905)

On Oct. 17, 1905, Mrs. H. W. H., aged 54, while running clothing from a second-story window out on an endless rope, was precipitated 15 feet below by the breaking of the rope. Careful examination revealed fracture of the right clavicle at its outer angle and of the left clavicle at its middle. The patient also suffered separation of the os innominatum from the sacrum at the right sacroiliac synchondrosis, with some traumatism to the sacral plexus of nerves.
TCT-321 Impact of Diabetes Duration on Long-term Clinical Outcomes following Coronary Revascularization: A Cohort Study From China's Largest Cardiac Center
Authors: Haiyang Gao, Erli Zhang, Qingrong Liu, Heng Zhang, Zhe He, Zhe Zheng, Bo Xu, Yongjian Wu, Yuejin Yang, Runlin Gao
Journal: Journal of the American College of Cardiology (2013)
High-frequency synchronisation in schizophrenia: Too much or too little?
Authors: Leanne M. Williams, Kwang-Hyuk Lee, Albert Haig, Evian Gordon
Journal: Behavioral and Brain Sciences (2003)

Abstract Phillips &amp; Silverstein's focus on schizophrenia as a failure of “cognitive coordination” is welcome. They note that a simple hypothesis of reduced Gamma synchronisation subserving impaired coordination does not fully account for recent observations. We suggest that schizophrenia reflects a dynamic compensation to a core deficit of coordination, expressed either as hyper- or hyposynchronisation, with neurotransmitter systems and arousal as modulatory mechanisms.
Hospital-Acquired Infections and Antibiotic Usage in the Boston City Hospital — January, 1964
Authors: Jay Ward Kislak, Theodore C. Eickhoff, Maxwell Finland
Journal: New England Journal of Medicine (1964)

INFECTION occurring during hospitalization is a major clinical and epidemiologic problem. Previous studies1 2 3 4 have focused primarily on hospital-acquired staphylococcal infections. Because of an impression that the frequency of such infections may have decreased and those caused by gram-negative bacilli correspondingly increased since the introduction of the penicillinase-resistant penicillins, a simple spot survey of clinically apparent infection acquired after admission to the Boston City Hospital was undertaken.MethodAll patients on the wards of the Boston City Hospital were seen by one or another of us during the week of January 21–27, 1964. Patients were considered to have hospital-acquired infection if . . .
Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo. Enoximone Multicenter Trial Group.
Authors: B F Uretsky, M Jessup, M A Konstam, G W Dec, C V Leier, J Benotti, S Murali, H C Herrmann, J A Sandberg
Journal: Circulation (1990)

A multicenter double-blind, randomized, placebo-controlled trial of oral enoximone, a phosphodiesterase inhibitor, was conducted in 102 outpatients (50 receiving enoximone and 52 receiving placebo) with moderate to moderately severe congestive heart failure. All were on a long-term regimen of digoxin and diuretics without vasodilators and converting enzyme inhibitors. Symptom score was obtained, and exercise testing was performed monthly for 4 months. There were no differences between groups in symptoms or exercise duration at the end of 4 months. A subgroup undergoing analysis of oxygen consumption with measurement of anaerobic threshold during exercise showed an increase (p less than 0.05) in anaerobic threshold at 1 month with enoximone. (2.7 +/- 0.8 ml O2/kg/min) compared with placebo (-0.8 +/- 1.2 ml O2/kg/min). This improvement was not sustained at 4 months (0.5 +/- 1.7 ml O2/kg/min with enoximone and 0.2 +/- 1.5 ml O2/kg/min with placebo). The dropout rate was significantly higher (p less than 0.02) with enoximone (46%) than with placebo (25%). Adverse effects other than death were slightly, but not significantly, higher with enoximone (32%) than with placebo (22%). During therapy, five deaths occurred in the enoximone group, and none occurred in the placebo group (p less than 0.05). Two deaths were sudden, two were from progressive congestive heart failure, and one was from acute myocardial infarction. With intention-to-treat analysis and inclusion of patients who were removed from therapy because of lack of study drug effect, 10 deaths occurred in the enoximone group, and three occurred in the placebo group (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Points from letters: Consultants' views of general practitioners
Authors: D. M. MacManus
Journal: BMJ (1967)

previously thought in young diabetics.I wish to record a recent case.A 12-year-old girl, a known diabetic for six months, had been controlled on 42 units of lente insulin daily.On the day of admission she had received her insulin and was complaining of faintness and vomiting.On examination she was ketotic and dehydrated.Urine sugar was 2% and acetone + + +.Her maximum blood sugar was 253 mg./100 ml., serum sodium 110 mEq/l., the serum potassium 4.6 mEq/l., and serum bicarbonate 3.5 mEq/l.On venepuncture the blood was pink and greasy.The serum was milky in appearance.She was treated with soluble insulin and intravenous infusion.Her serum cholesterol was 830 mg./100 ml. on the first day, and on the third, seventh, and fourteenth days was 225 mg./100 ml., 272 mg./100 ml., and 172 mg./100 ml., respectively.This case of diabetic lipaemia occurred in a girl well until 24 hours prior to admission, and cleared after two days.She has remained well since on only 60 units of lente insulin daily.
Proceedings: Symposium on the future of sports medicine in Britain. Some academic aspects.
Authors: J. E. Kane
Journal: British Journal of Sports Medicine (1975)

29overcome them where possible.3. It is not a fitness Council and seeks to promote sport as a natural, worthwhile and enjoyable form of human expression which eminently deserves support in its own right and for its own sake.4. It has not assumed any responsibility in the 'pure science' aspects of physiology or biomedicine; the M.R.C. and the S.R.C. exist to fund work in these areas.Nor is it the Sports Council's role to be concerned with the training of doctors, physiologists, sports medicine specialists and researchers.Even a cursory checking through the journals mentioned reveals the way in which sports medicine is defined operationally.Contributions from physicians and experts in applied physiology, traumatology and
Diabetes Fear of Injecting and Self-Testing Questionnaire: a psychometric evaluation.
Authors: E D Mollema, F J Snoek, F Pouwer, R J Heine, H M van der Ploeg
Journal: Diabetes Care (2000)

OBJECTIVE: To study the psychometric properties of the Diabetes Fear of Injecting and Self-Testing Questionnaire (D-FISQ). RESEARCH DESIGN AND METHODS: Two groups of patients were studied. Sample A consisted of 252 insulin-treated diabetes patients. Sample B incorporated 24 insulin-treated patients with high scores (&amp;gt; or = 95th percentile) on the D-FISQ. Test-retest correlations were assessed in both samples. Discriminant and convergent validity of the D-FISQ were assessed with questionnaires concerning fear of hypoglycemia, trait anxiety, and fear of bodily injury, illness, or death. To evaluate criterion-related validity, sample B participated in a behavioral avoidance test (BAT), in which the current level of avoidance of either self-injecting or self-testing was determined. Exploratory factor analysis (EFA) was performed to study whether 2 factors (fear of self-injecting [FSI] and fear of self-testing [FST]) could be detected. RESULTS: Test-retest correlations ranged from 0.50 to 0.68 (P &amp;lt; 0.001). Correlations between D-FISQ and fear of hypoglycemia, trait anxiety, and fear of bodily injury, illness, or death ranged from 0.28 to 0.45 (P &amp;lt; 0.001). Patients who refused to do a BAT for self-injecting or self-testing had higher scores on FSI (P = 0.095) and FST (P = 0.01). EFA yielded 2 separate factors, FSI and FST. CONCLUSIONS: Results from this study support reliability and validity of the D-FISQ, a self-report instrument that can be used for both clinical and research purposes.
Nuclear power plants do not raise risk of leukaemia in children, study finds
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Living near a nuclear power plant does not raise the risk of leukaemia or non-Hodgkin lymphoma in children aged under 5 years, a review of cases in Britain over 45 years has found.

The incidence of leukaemia near nuclear power plants in Britain was first highlighted in a television documentary in 1983 that found an excess of cancer cases among young people living near the Sellafield plant in Cumbria. A year later a report confirmed a large and unexpected incidence of childhood leukaemia in the nearby coastal village of Seascale, which led to the establishment of the Committee on Medical Aspects of Radiation in the Environment. 

The committee found a very small or no …
Phobias and their management.
Authors: I Marks, J Horder
Journal: BMJ (1987)

Disabling phobias and phobia like compulsive rituals are surprisingly common in the general population, though only a minority ask for help. Behavioural treatment (exposure) and antidepressants are the most helpful approaches. Most patients can help themselves if they use a self exposure approach systematically under the guidance of a clinician. The method seems well suited for use by general practitioners. Anti-depressants are a useful adjuvant, not a substitute, for exposure when there is evidence of depression complicating the phobias or rituals.
Case 27-1969
Authors: Arthur K. Asbury, Donald L. Price, Kilmer S. McCully
Journal: New England Journal of Medicine (1969)

Presentation of Case First admission. A sixty-one-year-old man was admitted to the hospital because of weakness of the arm and leg.For many years he had had hypertension; with guanethidine and hydrodiuril therapy the blood pressure was maintained at 190 systolic, 95 to 100 diastolic. During the five years before admission he had experienced intermittent claudication in the legs and a sensation of substernal pressure after walking. Ten months before entry there was an episode of paroxysmal atrial fibrillation of twenty-four hours' duration. Two weeks later he had a five-minute episode of transient weakness of the left arm and leg, . . .
Echocardiographic Patterns in the Systolic-Click—Late Systolic-Murmur Syndrome.
Authors: R. E. Kerber
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Echocardiographic Patterns in the Systolic-Click—Late Systolic-Murmur Syndrome.R. E. Kerber, M.D., D. M. Isaeff, M.D., E. W. Hancock, M.D., F.A.C.P.R. E. Kerber, M.D.Search for more papers by this author, D. M. Isaeff, M.D.Search for more papers by this author, E. W. Hancock, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-820_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTen patients with systolic clicks and late systolic murmurs documented phonocardiographically were studied using reflected ultrasound. In six patients the anterior leaflet of the mitral valve displayed an abrupt posterior motion in midsystole, coincident with the systolic click and onset of the systolic murmur. A similar motion of the posterior leaflet of the mitral valve was recorded definitely in one patient and possibly in three additional patients; a visible separation of the mitral valve leaflets in midsystole was thus produced. In only 1 of the 10 patients did the recorded mitral valve motion appear normal. Six additional patients with systolic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. E. Kerber, M.D.; D. M. Isaeff, M.D.; E. W. Hancock, M.D., F.A.C.P.Affiliations: Palo Alto, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 820-820KeywordsSystolic ejection murmurUltrasound imaging ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
Abstract 2355: Telomere length of tumor tissues and survival in patients with early stage non-small cell lung cancer .
Authors: Ji Woong Song, Hyo-Sung Jeon, Eung Bae Lee, Shin Yup Lee, Jae Yong Park
Journal: Cancer Research (2013)

Abstract Telomere shortening leads to genomic instability that drives oncogenesis through the activation of telomerase and the generation of other mutations necessary for tumor progression. This study was conducted to determine the impact of telomere shortening on the survival of patients with early stage non-small cell lung cancer (NSCLC). Relative telomere length in tumor tissues was measured by quantitative polymerase chain reaction in 164 patients with surgically-resected NSCLC. The association between telomere length and overall survival (OS) and disease-free survival (DFS) was analyzed. When the patients were categorized into quartiles based on telomere length, those patients with the 1st quartile (shortest) of telomere length had a significantly worse OS and DFS compared to patients with the 2nd to the 4th quartiles of telomere length (adjusted hazard ratio for OS = 2.67, 95% confidence interval = 1.50-4.75, P = 0.001; and adjusted hazard ratio for DFS = 1.92, 95% confidence interval = 1.17-3.14, P = 0.01). An association between telomere length and survival outcome was more pronounced in squamous cell carcinomas than adenocarcinomas (P-value of test for homogeneity for OS and DFS = 0.05 and 0.02, respectively). Telomere length of tumor tissues is an independent prognostic factor in patients with surgically resected early stage NSCLC. Citation Format: Ji Woong Song, Hyo-Sung Jeon, Eung Bae Lee, Shin Yup Lee, Jae Yong Park. Telomere length of tumor tissues and survival in patients with early stage non-small cell lung cancer . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2355. doi:10.1158/1538-7445.AM2013-2355
Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells
Authors: Caterina Vitali, Francesca Mingozzi, Achille Broggi, Simona Barresi, Francesca Zolezzi, Jagadeesh Bayry, Giorgio Raimondi, Ivan Zanoni, Francesca Granucci
Journal: Blood (2012)
AUTOGENOUS VACCINE THERAPY IN ENDOCARDITIS
Authors: E. C. ROSENOW
Journal: JAMA (1910)

The therapeutic value of the injection of dead bacteria in certain localized infections, particularly those of long duration, can no longer be questioned. Their effect in the more generalized infections, particularly in endocarditis, is still very questionable. Wright, 1 Conder, 2 Barr and Bell, 3 report one case each of recovery, while Thompson 4 reports three recoveries out of a total of seven cases of endocarditis under vaccine treatment. Others have reported a few recoveries. A study of the cases of recovery shows that all were acute infections caused by more or less highly virulent organisms following a definite often severe local infection, and usually developing metastatic abscesses, the cases presenting a picture of pyemia; the type of endocarditis from which every now and then a patient recovers quite independently of the kind of treatment. Horder, 5 Billings, 6 Osler, 7 Libman and others have had uniformly negative results. The
Topical psoralen plus ultraviolet A treatment for necrobiosis lipoidica
Authors: D.B. McKenna, E.J. Cooper, M.J. Tidman
Journal: British Journal of Dermatology (2000)

Journal Article Topical psoralen plus ultraviolet A treatment for necrobiosis lipoidica Get access D.B. McKenna, D.B. McKenna Department of Dermatology, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar E.J. Cooper, E.J. Cooper Department of Dermatology, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.J. Tidman M.J. Tidman Department of Dermatology, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 6, 1 December 2000, Pages 1333–1335, https://doi.org/10.1046/j.1365-2133.2000.03922.x Published: 01 December 2000
To be or not to be--an incretin or enterogastrone?
Authors: M Horowitz
Journal: Gut (2006)

<h3>OBJECTIVE</h3> The genes for killer cell inhibitory receptors (KIRs) have been cloned and their functions and responses to other molecules, including cytokines, have been partially clarified. However, the expression of KIRs has not been analysed in patients with autoimmune diseases, such as rheumatoid arthritis (RA), who are highly susceptible to microbial infection. Therefore, KIR expression on lymphocytes in patients with RA, and the regulation of KIR expression by interleukin 2 (IL2) in RA was investigated. <h3>METHODS</h3> CD158a/b expression on peripheral blood mononuclear cells (PBMC) obtained from 25 patients with RA and 14 healthy subjects was analysed by flow cytometry. Additionally, PBMC from the two groups of subjects were cultured in RPMI 1640 medium with or without IL2 for 48 hours, and then their CD158a/b expression was analysed. <h3>RESULTS</h3> The rate of CD158a expression on the CD8+ cells was lower in patients with RA than in healthy subjects, though there was no significant difference in the CD158a/b expression on the CD16+ cells between the two groups. The upregulation of CD16+CD158a/b+ cells in response to IL2 was significantly reduced in patients with RA compared with healthy subjects. <h3>CONCLUSION</h3> The reduced induction of KIR expression in response to IL2 may provide insight into the reason for the high susceptibility of patients with RA to microbial infection.
<scp>NI</scp>‐1: a novel canine mastocytoma model for studying drug resistance and <scp>I</scp>g<scp>ER</scp>‐dependent mast cell activation
Authors: E. Hadzijusufovic, B. Peter, H. Herrmann, T. Rülicke, S. Cerny‐Reiterer, K. Schuch, L. Kenner, T. Thaiwong, V. Yuzbasiyan‐Gurkan, W. F. Pickl, M. Willmann, P. Valent
Journal: Allergy (2012)

Abstract Background Advanced mast cell ( MC ) disorders are characterized by uncontrolled growth of neoplastic MC in various organs, mediator‐related symptoms, and a poor prognosis. Kit mutations supposedly contribute to abnormal growth and drug resistance in these patients. Methods We established a novel canine mastocytoma cell line, NI ‐1, from a patient suffering from MC leukemia. Results NI ‐1 cells were found to form mastocytoma lesions in NOD / SCID IL ‐2 R gamma null mice and to harbor several homozygous Kit mutations, including missense mutations at nucleotides 107( C → T ) and 1187( A → G ), a 12‐bp duplication (nucleotide 1263), and a 12‐bp deletion (nucleotide 1550). NI ‐1 cells expressed several MC differentiation antigens, including tryptase, K it, and a functional I g E receptor. Compared to the C 2 mastocytoma cell line harboring a Kit exon 11 mutation, NI ‐1 cells were found to be less responsive against the K it tyrosine kinase inhibitors ( TKI ) masitinib and imatinib, but were even more sensitive against proliferation‐inhibitory effects of the mammalian target of rapamycin ( mTOR ) blocker RAD 001 and PI 3‐kinase/ mTOR blocker NVP ‐ BEZ 235. The K it‐targeting multikinase inhibitors PK C412 and dasatinib were also found to override TKI resistance in NI ‐1 cells, and produced growth inhibition with reasonable IC 50 values (&lt;0.1 μM). Conclusion NI ‐1 may serve as a useful tool to investigate I g E ‐dependent reactions and mechanisms of abnormal growth and drug resistance in neoplastic MC in advanced mastocytosis.
Metabolic Oncologic Emergencies
Authors: D. J. Glover, J. H. Glick
Journal: CA A Cancer Journal for Clinicians (1987)

With improvements in antitumor therapy, it is important to recognize life-threatening metabolic emergencies that may be reversed by prompt treatment. Accurate diagnosis and treatment of metabolic emergencies may both improve quality of life and increase survival, allowing more oncology patients to receive an adequate trial of definitive therapy designed to eradicate or palliate their disease.