tbuckley/cabot-search huggingface dataset:
Bee Bite and the Toxic Shock Syndrome
Authors: RONALD KLUG
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 March 1982Bee Bite and the Toxic Shock SyndromeRONALD KLUG, M.D., RICHARD IMMERMAN, M.D., JOSE A. GIRON, M.D.RONALD KLUG, M.D.Search for more papers by this author, RICHARD IMMERMAN, M.D.Search for more papers by this author, JOSE A. GIRON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-382_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report an unusual case of toxic shock syndrome.A 25-year-old man was stung on the left lower back by a bee 6 days before admission. There had been no immediate reaction but 3 days before admission a red pruritic rash had appeared around his groin and had spread to his back and trunk by the next day. The day before admission the rash had further spread to both antecubital areas, and he had had fever, shaking chills, anorexia, severe myalgias, and arthralgias. That evening he had had some neck stiffness; photophobia; and headache without dizziness, disorientation,...References1. TODDFISHANTKAPRAL JMF. Toxic shock syndrome associated with phage-group I staphylococci. Lancet. 1978;2:1116-8. CrossrefMedlineGoogle Scholar2. TOFTEWILLIAMS RD. Toxic shock syndrome: evidence of a broad clinical spectrum. JAMA. 1981;246:2163-7. CrossrefMedlineGoogle Scholar3. . Morbid Mortal Weekly Rep. 1980;29:229-30. Google Scholar4. TOFTEWILLIAMS RD. Toxic shock syndrome: clinical and laboratory features in 15 patients. Ann Intern Med. 1981;94:149-56. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Queens Hospital Center Affiliation The Long Island Jewish-Hillside Medical Center Jamaica, NY 11432 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAnimal Studies of Toxic Shock Syndrome 1 March 1982Volume 96, Issue 3Page: 382-382KeywordsArthralgiaBeesFeversHeadachesMyalgiaRashesStiffnessToxic shock syndrome Issue Published: 1 March 1982 PDF DownloadLoading ...
Medical Thinking: A Historical Preface
Authors: William C. Gibson
Journal: JAMA (1982)

This is a scholarly statement of the ingredients of medical progress made, sometimes slowly, over man's written history. It is no mere recounting of alleged "milestones" in any popular sense. Rather, it is an analytical and carefully documented account of man's attempt to meet the recurrent diagnostic problems posed by patients from historic times to the present. Instead of denigrating the efforts of early physicians in this regard, Dr King, a highly qualified pathologist and teacher, holds up for all to see the imaginative and innovative theories that have tried to account for major disease entities. In this elegantly produced volume, the reader will find just the right mix of the personal history of the discoverers or contributors of the past along with a clear statement of the problems addressed. An excellent feature of the treatise is the clarification for today's readers of the descriptive terms used by earlier writers.
TCT-667 Relationship Between Renal Function and Lesion Morphology: An ADAPT-DES VH-IVUS sub-study
Authors: Shigeo Saito, Gary S. Mintz, Bernhard Witzenbichler, D. Christopher Metzger, Michael Rinaldi, Ernest L. Mazzaferri, Peter L. Duffy, Giora Weisz, Thomas Stuckey, Bruce R. Brodie, Ke Xu, Gregg Stone, Akiko Maehara
Journal: Journal of the American College of Cardiology (2013)
Comparative hazards of chrysotile asbestos and its substitutes: A European perspective.
Authors: P T Harrison, L S Levy, G Patrick, G H Pigott, L L Smith
Journal: Environmental Health Perspectives (1999)

Although the use of amphibole asbestos (crocidolite and amosite) has been banned in most European countries because of its known effects on the lung and pleura, chrysotile asbestos remains in use in a number of widely used products, notably asbestos cement and friction linings in vehicle brakes and clutches. A ban on chrysotile throughout the European Union for these remaining applications is currently under consideration, but this requires confidence in the safety of substitute materials. The main substitutes for the residual uses of chrysotile are p-aramid, polyvinyl alcohol (PVA), and cellulose fibers, and it is these materials that are evaluated here. Because it critically affects both exposure concentrations and deposition in the lung, diameter is a key determinant of the intrinsic hazard of a fiber; the propensity of a material to release fibers into the air is also important. It is generally accepted that to be pathogenic to the lung or pleura, fibers must be long, thin, and durable; fiber chemistry may also be significant. These basic principles are used in a pragmatic way to form a judgement on the relative safety of the substitute materials, taking into account what is known about their hazardous properties and also the potential for uncontrolled exposures during a lifetime of use (including disposal). We conclude that chrysotile asbestos is intrinsically more hazardous than p-aramid, PVA, or cellulose fibers and that its continued use in asbestos-cement products and friction materials is not justifiable in the face of available technically adequate substitutes.
alpha-Adrenergic receptors and coronary spasm: an elusive link.
Authors: S Chierchia, G Davies, G Berkenboom, F Crea, P Crean, A Maseri
Journal: Circulation (1984)

In 14 consecutive patients with variant angina we investigated the possible role of coronary alpha-adrenergic receptors in the genesis of coronary spasm. In eight patients, computerized, beat-by-beat analysis of the electrocardiogram recorded during continuous Holter monitoring failed to reveal any increase of heart rate and corrected QT interval (both indexes of cardiac sympathetic activation) in the period preceding the onset of ST segment changes in 197 episodes of ischemia caused by coronary spasm. In the same patients, analysis of the circadian distribution of ischemic episodes revealed a significantly higher incidence in the early morning hours, when sympathetic activity is at the lowest level. Twelve patients underwent serial provocative testing with cold pressor, phenylephrine, or norepinephrine infusion and administration of ergonovine maleate. Ergonovine consistently reproduced coronary spasm in all 12 patients, while results of cold pressor testing were positive in only one. Infusion of phenylephrine (eight patients) or norepinephrine after beta-blockade (four patients) failed to precipitate myocardial ischemia. In five patients infusion of phentolamine at the highest tolerated dose did not reduce significantly the number of ischemic attacks when compared with placebo. In contrast to results of previous reports, our data seem to rule out the hypothesis that an increase of sympathetic outflow to the heart plays an important role in the genesis of coronary spasm. We cannot, however, exclude the possibility of localized alpha-stimulation of epicardial arteries.
Relations between Pain, Anxiety, Mood and Muscle Tension in Chronic Pain Patients
Authors: Steven J. Linton, Gunnar Götestam
Journal: Psychotherapy and Psychosomatics (1985)

The relationship between psychological variables, particularly depressed mood and anxiety, and pain has received a good deal of attention. In this study, 16 chronic pain patients rated their mood, anxiety level, pain, muscle tension, and reclining time daily over a period of about 6 weeks. Correlations were calculated for each combination of variables for each individual patient. The results indicated a good deal of variability between patients. The majority of patients did have significant correlations for pain vs. mood, pain vs. anxiety, pain vs. reclining time, anxiety vs. muscle tension, anxiety vs. mood, and reclining time vs. mood. However, the size of the correlations was sometimes small, and some patients even occasionally had correlations in the opposite direction of that predicted. Overall, the data suggest that psychological variables are related to the experience of chronic pain, but that the size of the relationship may be smaller than previously thought. Furthermore, the high degree of individual variability needs to be stressed.
MORVAN'S DISEASE; WITH THE CLINICAL REPORT OF A CASE.Read before the Chicago Medical Society. March 2, 1891.
Authors: ARCHIBALD CHURCH
Journal: JAMA (1891)

The first description of the diseased state which by courtesy and for convenience may be called "Morvan's disease," was made by Dr. Morvan, of Lannelis, in Brittany, and published in the<i>Gazette hebdomidaire de Médicine et de Chirurgie</i>in 1883, under the title of "Parésie Analgesique avec Panaris des Extremities Superieures." Since that date he has made numerous communications on the same subject in the same journal, with the reports of eighteen cases. In 1885 M. Broca (<i>Ann. de Dermat. et de Syphilog</i>.) published a case, and in 1887 M. Prouff (<i>Gazette Hebdom</i>.), another Breton physician, recorded one, followed by Hanoi in the same year. In 1888 d'Oger de Speville collated in a Paris thesis nine cases from various sources. In 1889 Heckel published a clinical observation (<i>Berlin Klin. Wochenschrift</i>). The same year (<i>Sem. Méd.</i>), Gombault reported the autopsy of Prouff's case before the Sociéte Medicale des Hôpitaux de
Fatal Pulmonary Intra-Alveolar Fibrosis after Paraquat Ingestion
Authors: Graeme M. Copland, Arnošt Kolín, Harry S. Shulman
Journal: New England Journal of Medicine (1974)

THE herbicidal properties of paraquat were discovered in 1955, and it has been in widespread use in Europe since 1958. Several million gallons1 are now used annually, and more than 120 deaths have been reported after its ingestion.2 Mortality after accidental ingestion has been said to be from 33 to 50 per cent.2 A list of the weed killers containing paraquat is presented in Table 1.We report a fatal North American case with some unusual histologic features.Case ReportAfter the ingestion of a "mouthful" of paraquat, a 39-year-old man was hospitalized, and a gastric lavage performed. Initial physical examination . . .
Impact of effective tumor necrosis factor-alfa inhibitor treatment on arterial intima-media thickness in psoriasis: Results of a pilot study
Authors: Hajnalka Jókai, József Szakonyi, Orsolya Kontár, Márta Marschalkó, Klára Szalai, Sarolta Kárpáti, Péter Holló
Journal: Journal of the American Academy of Dermatology (2013)
The relationship between cardiac and liver iron evaluated by MR imaging in haematological malignancies and chronic liver disease
Authors: J M Virtanen, K J Remes, M A Itälä-Remes, J P Saunavaara, M E Komu, A M Partanen, R K Parkkola
Journal: Blood Cancer Journal (2012)

Although iron overload is clinically significant, only limited data have been published on iron overload in haematological diseases. We investigated cardiac and liver iron accumulation by magnetic resonance imaging (MRI) in a cohort of 87 subjects who did not receive chelation, including 59 haematological patients. M-HIC (MRI-based hepatic iron concentration, normal values <36 μmol/g) is a non-invasive, liver biopsy-calibrated method to analyse iron concentration. This method, calibrated to R2 (transverse relaxation rate), was used as a reference standard (M-HIC(R2)). Transfusions and ferritin were evaluated. Mean M-HIC(R2) and cardiac R* of all patients were 142 μmol/g (95% CI, 114–170) and 36.4 1/s (95% CI, 34.2–38.5), respectively. M-HIC(R2) was higher in haematological patients than in patients with chronic liver disease or normal controls (P<0.001). Clearly elevated cardiac R2* was found in two myelodysplastic syndrome (MDS) patients with severe liver iron overload. A poor correlation was found between liver and cardiac iron (n=82, r=0.322, P=0.003), in contrast to a stronger correlation in MDS (n=7, r=0.905, P=0.005). In addition to transfusions, MDS seemed to be an independent factor in iron accumulation. In conclusion, the risk for cardiac iron overload in haematological diseases other than MDS is very low, despite the frequently found liver iron overload.
Abstract 4962: TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells
Authors: Hector R. Biliran, Scott Jennings, Shubha Skale Ireland, Chris Brunquell, Renwei Chen, Erkki Ruoslahti
Journal: Cancer Research (2012)

Abstract TLE1 is a Groucho related transcriptional repressor protein that exerts survival and anti-apoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer. In the present study, we found that TLE1 is a critical regulator of anoikis in normal mammary epithelial and breast carcinoma cells. The induction of apoptosis following loss of cell attachment to the extracellular matrix (ECM) (anoikis) in untransformed mammary epithelial MCF10A cells was associated significant downregulation of TLE1 expression while forced expression of exogenous TLE1 in these cells promoted resistance to anoikis. In stark contrast, TLE1 expression was significantly upregulated following detachment from the ECM in malignant and anoikis resistant breast cancer cell lines, MDA-MB-231 and MCF7. Importantly, enforced suppression of TLE1 in these cells resulted in attenuation of anoikis resistance and decreased anchorage-independent growth with no impact on cell viability in adherent conditions. Consistently, enforced ectopic TLE1 expression further enhanced the anoikis resistance and anchorage-independent growth of MDA-MB-231 cells. The pro-survival and anti-apoptotic role of TLE1 during loss of cell attachment is in part attributed to its ability to inhibit the caspase-independent anoikis function of Bit1. Interestingly, the TLE1 protein is channelled to proteosomal degradation by Bit1 during anoikis. Taken together, these findings indicate a novel role for TLE1 in the maintenance of anoikis resistance in breast cancer cells. This conclusion is supported by an immunohistochemical analysis of a breast cancer tissue array illustrating that TLE1 is selectively upregulated in invasive breast tumors relative to noninvasive ductal carcinoma in situ (DCIS) and normal mammary epithelial tissues. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4962. doi:1538-7445.AM2012-4962
The 51st Landmark Article
Authors: Marc H. Hollender
Journal: JAMA (1983)

FIFTY landmark articles, published inThe Journalduring its first century, will be republished during this, the centennial, year. Doing so seems most appropriate. But what about the articles that were rejected because they were too far ahead of their time? No matter how careful the scrutiny or how sound the judgment of an editor, it is to be expected that some important articles would be turned down. A notable instance is the preceding article by Denslow Lewis, MD, entitled "The Gynecologic Consideration of the Sexual Act," presented at the annual meeting of the American Medical Association in 1899. Howard A. Kelly of Johns Hopkins, a discussant of the paper, stated that the discussion of sex "is attended with more or less filth and we besmirch ourselves by discussing it in public," and George H. Simmons, editor ofThe Journal, stated that he was opposed to publishing "this class of
Aid agencies fear for future of pastoralists in Horn of Africa
Authors: Peter Moszynski
Journal: BMJ (2007)

The prime minister set out his priorities for the health service in the Queen's speech this week-with plans to legislate for a new quality control regulator and changes in the way doctors are regulated and in the rules concerning assisted reproduction and embryo research.Gordon Brown used his first Queen's speech to announce the creation of a new regulator, whose aim will be "to ensure clean and safe services and high quality care."The new body for England, to be known as the Care Quality Commission (or Ofcare for short), will take over the functions of the Healthcare Commission, the Commission for Social Care Inspection, and the Mental Health Act Commission.It will be set up under the proposed Health and Social Care Bill and will have the authority to fine hospitals and shut down wards.The Health and Social Care Bill also includes UK-wide measures to abandon the criminal standard of proof (that is, beyond reasonable doubt) in cases where doctors' fitness to practise is questioned.Instead doctors could be struck off the medical register on the lower civil standard of "balance of probabilities."The draft Human Tissue and Embryo Bill, which was published in May this year, will also be debated in the next session of parliament.It aims to update the Human Fertilisation and Embryology Act 1990, which is based on scientific knowledge and debate from the 1980s.The new bill has already been criticised by a cross party group of MPs and peers, in a report published in August.The committee said that the new bill should include a provision to record on birth certificates the fact that a child has been born after egg or sperm donation.At the moment parents are not obliged to tell children that they were conceived from donated sperm or eggs, and children can't check who their biological parents are until they reach the age of 18. Queen speech gives plans for new health regulatorUK NEWS Annual incidence of MRSA falls in England, p 959 WoRld NEWS A �a��e�� of life o�� dea���� ��ina�s ���ansplan�a�ion p��ac�ice, p 9��A �a��e�� of life o�� dea���� ��ina�s ���ansplan�a�ion p��ac�ice, p 9�� , p 9�� b�j.co�Suicide ��a�e of �o�en doc�o��s in US is ��ice ��a� of o��e�� �o���ing �o�en Suicide ��a�e of �o�en doc�o��s in US is ��ice ��a� of o��e�� �o���ing �o�en
Pleuritic pain: Fitz Hugh Curtis syndrome in a man.
Authors: A C Davidson, D A Hawkins
Journal: BMJ (1982)

Pleurisy of the right side that occurs as a feature of gonococcal infection and is related to a perihepatitis is called the Fitz Hugh Curtis syndrome.12 The syndrome may also be caused by Chlamydia trachomatis.3 4 This syndrome has been confused with cholecystitis, pneumonia, pulmonary embolism, and perforation of a viscus.5 It may be overlooked and underreported.6 There have been two reports of it in men.7 8 We report on a man in whom the diagnosis was confused. The case highlights the frequency with which multiple infections are acquired sexually.
Electrocardiogram, Myocardial Oxygen and Contraction in Scar and Collaterally Supplied Muscle After Experimental Coronary Ligation
Authors: John J. Sayen, Warner F. Sheldon, George Peirce, Aaron H. Katcher, Peter T. Kuo
Journal: Circulation Research (1962)

Studies of myocardial electrocardiograms, oxygen, and cinematographic muscle contraction were carried out in dogs during coronary branch ligation and after 2 to 12 weeks' recovery. Scars were found in 12 of 13 animals. Five were transmural at some point and seven entirely subendocardial. Myocardial electrocardiographic abnormalities were found in every animal with a scar. Epicardial electrocardiographic abnormalities (localized Q waves or low R waves) were roughly conterminous with the surface projection of the entire extent of all transmural scars and of six out of seven subendocardial scars. Precordial leads were abnormal in only three animals, all with transmural scars. Responses to oxygen inhalation, hypoxia, and levarterenol for these animals were within the range of normal variation, but there was a tendency to develop ventricular fibrillation, unrelated to the amount of scar. Study of the acute ischemic dysfunction consequent to coronary ligation is not of great value for the interpretation of the situation at re-exploration two or more weeks later. The behavior of recovered collaterally supplied muscle, assessable by the techniques employed in these studies (provided that epicardial thickening has been avoided by minimizing exposure and trauma at the time of ligation), has relevance to many human coronary disease situations in which regional circulation is carried on by intramyocardial or small caliber vessels.
Anaesthesia in War Time
Authors: R. R. Macintosh, F. B. Pratt
Journal: BMJ (1939)

<h3>ABSTRACT</h3> This literature review presents a quantitative synthesis of 57 studies on product placement and shows which factors are most effective. It shows that placement characteristics, such as placement commerciality, modality, and prominence, have a strong impact on audience reactions. Audience characteristics, such as attitudes and beliefs about brand placement, advertising, and media, also shape audience reactions to brand placement. Advertising and psychological theories provide valuable explanations for the majority of the effects. However, the authors call for development of theories on capacity constraints and implicit processing as these can explain effects that are specific to brand placement.
Puerperal Fever Treated by Antistreptococcus Serum
Authors: H. L. G. Leask
Journal: BMJ (1896)

Low molecular weight (LMW) IgM is the monomeric subunit of pentameric IgM. It was not found in the sera of 20 healthy subjects but was detected in all six patients with mixed cryoglobulinaemia with a mean value of 1.4 g/l, representing 34% of the total IgM. In three of four patients studied LMW IgM was monoclonal and of the same light chain type (kappa) as the pentameric monoclonal IgM rheumatoid factor (RF) observed in the cryoprecipitate. LMW IgM was proportionately under-represented, however, in the cryoprecipitate compared with the corresponding serum, possibly because of the lower valency of the LMW molecule. Immunoblot analysis of sera showed the presence of other oligomers of IgM in addition to monomeric IgM, suggesting that a disorder of IgM assembly was responsible for its occurrence, and this was supported by the secretion of large proportions of LMW IgM in vitro by peripheral blood mononuclear cells (PBMC) from one patient with this disorder but not from healthy controls. In conclusion, the occurrence of large quantities of monoclonal LMW IgM in mixed cryoglobulinaemia was observed, and it is suggested that this is unlikely to have a direct pathogenic significance. It is postulated that its presence reflects a disturbance of assembly of the monomeric IgM subunits that occurs during the polymerization of the pentameric molecule.
Subacute Splenic Abscess
Authors: WALTER AMMANN, BRIAN K.Y. CHIU, JAMES M. WRIGHT
Journal: Clinical Nuclear Medicine (1986)

A case of a 23-year-old man with an encapsulated, anaerobic splenic abscess is reported. Both the In-111 leukocyte and Tc-99m sulfur colloid scans demonstrated an intrasplenic defect. The Ga-67 citrate scan revealed uptake in the rim of the abscess only where the abscess cavity was relatively photon-deficient. The combined Tc-99m sulfur colloid/In-111 leukocyte/Ga-67 scan appearance of a subacute splenic abscess has not been described previously. In cases suspected to be splenic abscesses the combined In-111 leukocyte/Tc-99m sulfur colloid imaging is the most useful.