tbuckley/cabot-search huggingface dataset:
Major rectal bleeding following transrectal needle prostate biopsy
Authors: B. Arroja, C. Gonçalves, F. Silva, I. Cotrim, H. Vasconcelos
Journal: Endoscopy (2009)

Transrectal ultrasound (TRUS)-guided prostate core biopsy is a very useful diagnostic tool in urological diseases. It constitutes a simple and safe outpatient procedure in the majority of patients, although hemorrhagic complications, ranging from transient hematuria to catastrophic rectal bleeding, may occur [1].
The Term Hispanic/Latino
Authors: Natalia Jaimes, Virginia Londono, Allan C. Halpern
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Heart rate-lowering calcium channel blockers (diltiazern, verapamil) do not adversely affect long-term cardiac death or non-fatal infarction in post-infarction patients: Data pooled from 3 randomized, placebo-controlled clinical trials of 5,677 patients
Authors: William E. Boden, Franz H. Messerli, Jørgen Fischer Hansen, Kenneth B. Schechtman
Journal: Journal of the American College of Cardiology (1996)
A Cohort Study of Fat Intake and Risk of Breast Cancer
Authors: Geoffrey R. Howe, Christine M. Friedenreich, Meera Jain, Anthony B. Miller
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article A Cohort Study of Fat Intake and Risk of Breast Cancer Get access Geoffrey R. Howe, Geoffrey R. Howe Search for other works by this author on: Oxford Academic PubMed Google Scholar Christine M. Friedenreich, Christine M. Friedenreich Search for other works by this author on: Oxford Academic PubMed Google Scholar Meera Jain, Meera Jain Search for other works by this author on: Oxford Academic PubMed Google Scholar Anthony B. Miller Anthony B. Miller Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 5, 6 March 1991, Pages 336–340, https://doi.org/10.1093/jnci/83.5.336 Published: 06 March 1991 Article history Received: 04 October 1990 Revision received: 06 December 1990 Accepted: 12 December 1990 Published: 06 March 1991
Launching the Healthy Michigan Plan — The First 100 Days
Authors: John Z. Ayanian, Sarah J. Clark, Renuka Tipirneni
Journal: New England Journal of Medicine (2014)

Interview with Dr. John Ayanian on the implementation and lessons of the Healthy Michigan Plan. (07:46)Download The early experience with Medicaid expansion in Michigan, a Republican-controlled state that received a federal waiver to implement modifications, may provide useful insights as this new coverage option continues to be debated and implemented in other states.
Parasympathetic nervous system in nocturnal asthma.
Authors: C. M. Gelder, D. Hubble, M. R. Hetzel
Journal: BMJ (1988)

furthcr by additional techniques such as computer aided diagnosis' and fine catheter aspiration peritoneal cytology.'Are Messrs Perry and Rhodes contcnt to continuc with their current surgical practice of performing an Linnecessary appendi- cectomy on one in five ot their patients while at the same time criticising the training and performance of others?
Enriched Formula Supplement Aids in Pressure Ulcer Healing
Authors: Anita Slomski
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Big Doctoring in America: Profiles in Primary Care
Authors: J. Chao
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transurethral Prostatic Resection After Myocardial Infarction
Authors: Gershom J. Thompson, Panayotis P. Kelalis, Daniel C. Connolly
Journal: JAMA (1962)

Transurethral prostatic resection performed on 192 men with previous myocardial infarction was followed by 9 postoperative deaths from cardiovascular disease. Three of these deaths followed resection performed soon after another major surgical procedure. Mortality was no greater in patients operated on within 6 months of infarction than in the series as a whole. Risk of operation, although increased by previous myocardial infarction, is acceptable if the patient has significant obstructive symptoms. It appears safer, after a recent major surgical procedure, to postpone transurethral surgery for 2 or even 3 months, during which time catheter drainage is used if necessary. It is concluded that transurethral prostatic resection should not be denied the patient with significant obstructive symptoms even though myocardial infarction has occurred previously.
Evaluation of a Risk Assessment Questionnaire Used to Target Tuberculin Skin Testing in Children
Authors: Philip O. Ozuah
Journal: JAMA (2001)

Context Universal tuberculin skin testing of children has been shown to be costly and inefficient.In response, several authorities have recommended targeted screening based on epidemiological risk.In 1996, the New York City Department of Health (NYCDOH) developed questions to identify children who require a tuberculin skin test.Objective To determine the sensitivity, specificity, and predictive validity of the NYCDOH tuberculosis risk assessment questionnaire.Design Prospective criterion standard study in which tuberculin skin tests and the NYCDOH questionnaire were administered simultaneously between August 1996 and January 1998.Specific questions asked about contact with a tuberculosis case, birth in or travel to endemic areas, regular contact with high-risk adults, and human immunodeficiency virus infection in the child.Setting Ambulatory clinic in South Bronx, New York, NY.Participants Consecutive sample of 2920 children aged 1 to 18 years. Main Outcome MeasuresSensitivity, specificity, positive and negative predictive values of the questionnaire, and odds ratio (OR) of reactive skin test results. ResultsThe NYCDOH questionnaire identified 413 children (14%) as having at least 1 risk factor.Of these, 23 (5.6%) had a positive skin test result; 4 (0.16%) of the 2507 without risk factors had a positive result.Results for the full NYCDOH questionnaire were sensitivity, 85.2%; specificity, 86.0%; negative predictive value, 99.8%; positive predictive value, 5.4%; and OR, 35.2 (95% confidence interval, 12.1-102.4). ConclusionThe NYCDOH questionnaire is a valid instrument for identifying children for tuberculin skin testing.
Professor files complaint of scientific misconduct over allegation of ghostwriting
Authors: B. Roehr
Journal: BMJ (2011)

A complaint of scientific misconduct has been filed with the US Office of Research Integrity regarding a ghostwritten paper on paroxetine (marketed as Paxil), published in 2001 in the American Journal of Psychiatry .

In the complaint Jay Amsterdam, a professor of psychiatry at the University of Pennsylvania and co-principal investigator of the paroxetine study 352 for bipolar depression, claims that he was “excluded from the final data review, analysis, and publication.”

Professor Amsterdam’s lawyer wrote in a letter to the university’s president, Amy Gutmann, “It is my client’s belief that the data from his study was effectively stolen from him, manipulated and used in a ghostwritten article . . . in order to advance a marketing scheme by GlaxoSmithKline to …
I.U.D. and uterine bleeding.
Authors: N K Bhide, S T Gogte
Journal: BMJ (1972)

The possibility that a water-soluble constituent of polyethylene intrauterine devices (IUD) contributes to uterine bleeding was investigated.  Lippes loop and Antigon IUDs were placed in a distilled water-saline solution and allowed to stand for 1-3 days. Samples of the solution were then combined with human or dog blood and the clotting time was measured.  In comparison to control solutions the clotting times for human and dog blood were significantly delayed in the IUD flui d (p = .001; p = .05 respectively).  A similar delay in clotting time was observed with solutions that had been exposed to an IUD for 18 months 3 days and 1 hour.  The findings may be explained by the low-solubility of the water-soluble IUD constitutent.
Abstract 5213: microRNA-mediated loss of KDM5B expression leads to suppression of the malignant bladder cancer phenotype
Authors: Abhimanyu Veerakumarasivam, Radha Kodiappan, Soon Choy Chan, Azad Hassan Abdul Razack, Teng Aik Ong
Journal: Cancer Research (2014)

Abstract We recently identified KDM5B as a putative oncogene. The expression of KDM5B correlated with increased cellular proliferative capacity and was found to be overexpressed in many cancers including bladder cancer (BC). KDM5B is a histone demethylase enzyme that modifies chromatin structure to specify cellular transcriptional states. It is a cancer/testis antigen; whereby in normal conditions, expression is limited to early embryonic stages and the testis in adults. Thus, KDM5B is an excellent therapeutic target. Since the expression of KDM5B in embryonic stem cells is orchestrated by miRNAs and that the expression of miRNAs are altered in BC, we hypothesized that miRNAs may be the switch that can abate the expression of KDM5B and thus affect the malignant phenotype of BC cells. This study was aimed at identifying and modulating the expression of miRNAs that are able to regulate KDM5B expression and BC phenotypes. By coupling in silico screens with RT-QPCR analysis of in vitro expression of BC cells of different malignant potential, we predicted several miRNAs as potential regulators of KDM5B transcripts. The functional effects of specific miRNAs on KDM5B expression, cell cycle, proliferation and invasion of BC cells was determined by modulating the expression of these miRNAs using mimics (upregulation) and antagomirs (downregulation). Expression of miR-137 in BC cells was found to be inversely correlated with KDM5B expression. Ectopic overexpression of miR-137 led to the repression of KDM5B expression, reduced cell growth and invasion as well as increased apoptosis of BC cells. In contrast, the downregulation of miR-137 expression led to reverse effects. The expression modulation of miR-137 also affected the expression of other BC-associated genes such as JDP2 and EGR2. While our results suggest that miR-137 can mitigate the KDM5B-associated BC phenotype, further studies on understanding the effect on aberrant histone methylation patterns are warranted. Citation Format: Abhimanyu Veerakumarasivam, Radha Kodiappan, Soon Choy Chan, Azad Hassan Abdul Razack, Teng Aik Ong. microRNA-mediated loss of KDM5B expression leads to suppression of the malignant bladder cancer phenotype. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5213. doi:10.1158/1538-7445.AM2014-5213
Finding the Right Balance of BRAF Inhibition in Melanoma
Authors: Michael A. Davies
Journal: Cancer Discovery (2014)

Abstract Summary: Paradoxical activation of the mitogen-activated protein kinase pathway can cause secondary malignancies in patients treated with inhibitors of BRAFV600 proteins. Characterization of a patient with concurrent BRAF-mutant melanoma and NRAS-mutant leukemia treated intermittently with combined BRAF and MEK inhibition provides new insights into the potential clinical and molecular effects of this therapeutic strategy. Cancer Discov; 4(5); 510–2. ©2014 AACR. See related article by Abdel-Wahab et al., p. 538
Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses
Authors: Hiroko Saito Akei, Eric B. Brandt, Anil Mishra, Richard T. Strait, Fred D. Finkelman, Manoj R. Warrier, Gurjit K. Khurana Hershey, Carine Blanchard, Marc E. Rothenberg
Journal: Journal of Allergy and Clinical Immunology (2006)
Cyclic Eosinophilic Myositis and Hyperimmunoglobulin-E
Authors: W. ASHLEY SYMMANS
Journal: Annals of Internal Medicine (1986)

A 40-year-old man had regular cyclic episodes of weight gain and eosinophilic myositis associated with hyperimmunoglobulin-E and hypereosinophilia for 9 years. During the episodes his body weight increased up to 10.8%; eosinophil counts reached 41.3 X 10-9 cells/L; and IgE levels reached 18 000 IU/mL. These values changed regularly in a definite sequence relative to the clinical state. Attempts to document a parasitic cause were unsuccessful, and several courses of antihelminthic therapy were ineffective. An oral dose of prednisone, 10 mg/d, begun in July 1982 resulted in an immediate lessening of the severity of the episodes and a progressive lengthening of the cycle from 35 to 170 days. No further episodes have occurred since March 1984. The patient is fit and well on prednisone therapy, 12.5 mg on alternate days. This apparently unique syndrome has a benign course and is a cyclic disease involving skeletal muscle as the target organ.
Government must give guidance on care of failed asylum seekers who cannot return home
Authors: C. Dyer
Journal: BMJ (2009)

Failed asylum seekers are not entitled to free treatment on the NHS in England, the Court of Appeal has ruled, overturning a High Court judgment last year.

But the appeal court judges held that, although NHS trusts have a discretion to withhold treatment, they also have a discretion to provide treatment even when a patient has no means of paying.

The judges ruled that Department of Health guidance to trusts on providing treatment for overseas visitors is “seriously misleading” in failing to tackle the question of failed asylum seekers who cannot return home. The guidance will have to be rewritten to set out how the discretion to withhold or provide treatment should be exercised in …
Influence of Chronic Aortic Insufficiency on the Coronary Artery Diameter
Authors: Hamza Sunman, Kadriye Yayla, Mehmet Erat, Furkan Şahan, Ali Nallbani, Mehmet Aytürk, Tolga Han Efe, Murat Bilgin, Ahmet Akyel, Tolga Çimen, Sadık Açıkel, Mehmet Doğan, Ekrem Yeter
Journal: Journal of the American College of Cardiology (2013)
Abstract P5-04-18: Identification of a novel combination therapy that prevents the metastatic outgrowth and reduces the viability of dormant breast cancer cells: implications for clinical translation
Authors: LH El Touny, A Vieira, A Mendoza, C Khanna, MJ Hoenerhoff, JE Green
Journal: Cancer Research (2013)

Abstract Recurrent metastatic disease many years after initial therapy is a major cause of breast cancer (BC) mortality and strongly suggests that disseminated cells survive long periods in a growth-arrested state that is refractory to chemotherapy, known as “cellular dormancy.” Alterations in the components of the extracellular matrix (ECM), such as fibrotic foci and collagen-1 (Col-1) deposition, are associated with more aggressive breast cancer, increased metastasis and poor prognosis for BC patients. This suggests that ECM alterations may have a role in influencing the behavior of dormant BC cells. In fact, we have previously shown both in vitro (using 3-dimensional culture) and in vivo (preclinical model of fibrosis at the lung metastatic site) that alterations in the ECM surrounding disseminated, dormant BC cells can induce signaling pathways requiring Src and ERK1/2 activation that switch dormant cells into a proliferative state. We now demonstrate using the Src inhibitor AD0530 or Src shRNA, that the proliferative outbreak of dormant BC cells in Col-1-enriched microenvironments is prevented through the induction of a reversible G1-phase arrest and the upregulation of nuclear cyclin dependent kinase inhibitor p27Kip1, without affecting the viability of the dormant cells. Src inhibition, however, is not efficacious in regressing already established metastatic lesions, suggesting that Src signaling is crucial to engage the dormant-to-proliferative switch but is not necessary for survival once the cells have begun to proliferate. Since ERK1/2 activation is also required for the dormant-to-proliferative switch, we determined the effect of the MEK1/2 inhibitor AZD6244 that prevents ERK1/2 activation on the proliferative switch alone and in combination with the Src inhibitor. Importantly, we show that combination treatment with AZD0530 and the MEK1/2 inhibitor AZD6244 of dormant cells undergoing the dormant-to-proliferative switch induces apoptotic cell death in a significant fraction of the dormant cells, which is not seen with either inhibitor alone, and significantly delays metastatic outgrowth in the lung metastatic site. In conclusion, inhibition of Src alone prevents the proliferative response of dormant cells to external stimuli without affecting survival, but the addition of a MEK1/2 inhibitor suppresses survival of dormant cells, indicating that this combination may have clinical value in preventing breast cancer recurrence. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-04-18.
Estimation of Brain Amine Metabolism in Affective Illness: Cerebrospinal Fluid Studies Utilizing Probenecid
Authors: Robert M. Post, Frederick K. Goodwin
Journal: Psychotherapy and Psychosomatics (1974)

In order to assess central serotonin and dopamine metabolism in patients with affective illness, cerebrospinal fluid amine metabolites 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) were measured under base-line conditions and after probenecid administration. Since probenecid inhibits transport of 5 HIAA and HVA out of CSF, their accumulation after probenecid provides an estimate of amine turnover. The 5HIAA and HVA accumulations were increased by the respective amine precursors, tryptophan and L-dopa, and were decreased by inhibitors of synthesis, parachlorphenylalanine and α-methylparatyrosine. In depressed and manic patients, 5HIAA levels were similar to those in controls while probenecid-induced accumulations of 5HIAA tended to be lower than those in controls. HVA accumulation in depressed patients was low compared to that in controls. Amitriptyline and imipramine treatment significantly lowered 5HIAA accumulation, suggesting that the tricyclic antidepressants decrease central serotonin turnover.
Rapid Serial Angiography in the Investigation of the Pharmacology of Brain Circulation in the Dog
Authors: GIANCARLO CANOSSI, BRUNELLO BRUNELLI, NICOLA CORTESI, AMILCARE CARPI
Journal: Circulation Research (1962)

The values of cerebral circulation time were determined by means of rapid serial angiography in the chloralosed dog under control conditions, after administration of strychnine and after injection of ergotamine. These results were compared with those obtained by the simultaneous registration of the intracranial venous pressure. Confirming previous observations made by means of this latter technique, the angiographic results showed that strychnine reduces the cerebral circulation time by provoking an increase in cerebral blood flow, whereas ergotamine causes a cerebral vasoconstriction, thereby increasing intracranial circulation time. Moreover, a statistically significant inverse correlation exists between the values of the intracranial pressure and the cerebral circulation time. New evidence of the relationship between the extra- and the intracranial circulation was obtained by the angiographic observations; these latter data are discussed in relation with the problem of the lability of cerebral vasoconstrictor reactions.