The Deletion Allele of Angiotensin-Converting Enzyme Gene Polymorphism as a Cardiovascular Risk Factor in Patients Undergoing Long-Term Hemodialysis
Authors: Toshihiko Ishimitsu
Journal: Annals of Internal Medicine (2000)

Letters5 December 2000The Deletion Allele of Angiotensin-Converting Enzyme Gene Polymorphism as a Cardiovascular Risk Factor in Patients Undergoing Long-Term HemodialysisToshihiko Ishimitsu, MD, Kazuyoshi Hosoya, MD, and Hiroaki Matsuoka, MDToshihiko Ishimitsu, MDDokkyo University School of Medicine; Mibu, Tochigi 321-0293, Japan (Ishimitsu, Hosoya, Matsuoka)Search for more papers by this author, Kazuyoshi Hosoya, MDDokkyo University School of Medicine; Mibu, Tochigi 321-0293, Japan (Ishimitsu, Hosoya, Matsuoka)Search for more papers by this author, and Hiroaki Matsuoka, MDDokkyo University School of Medicine; Mibu, Tochigi 321-0293, Japan (Ishimitsu, Hosoya, Matsuoka)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-11-200012050-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:There is continuing interest about the link between the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene and cardiovascular diseases. Previous studies have shown conflicting results on the association of the D allele and risk for cardiovascular disease (1-4). These reports were mostly based on cross-sectional observations, and prospective follow-up studies are needed to obtain a definitive conclusion.For 3 years, we followed 218 patients undergoing long-term hemodialysis and evaluated the relation of ACE gene polymorphism with the incidence of cardiovascular diseases. The numbers of patients with the II, ID, and DD genotypes were 93, 92, ...References1. Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, et al . Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature. 1992;359:641-4. CrossrefMedlineGoogle Scholar2. Winkelmann BR, Nauck M, Klein B, Russ AP, Bohm BO, Siekmeier R, et al . Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease. Ann Intern Med. 1996;125:19-25. LinkGoogle Scholar3. Butler R, Morris AD, Struthers AD. Angiotensin-converting enzyme gene polymorphism and cardiovascular disease [Editorial]. Clin Sci Colch. 1997;93:391-400. CrossrefGoogle Scholar4. Schunkert H. Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease. J Mol Med. 1997;75:867-75. CrossrefMedlineGoogle Scholar5. Eknoyan G. Cardiovascular mortality and morbidity in dialysis patients. Miner Electrolyte Metab. 1999;25:100-4. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Dokkyo University School of Medicine; Mibu, Tochigi 321-0293, Japan (Ishimitsu, Hosoya, Matsuoka) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Presence of PAI-1 4G/5G and ACE DD Genotypes Increases the Risk of Early-Stage AVF Thrombosis in Hemodialysis PatientsACE I/D polymorphism is associated with mortality in a cohort study of patients starting with dialysis 5 December 2000Volume 133, Issue 11Page: 924KeywordsAllelesAngiotensin converting enzymeCardiovascular diseasesHeart failureMedical risk factorsMyocardial infarctionProspective studiesRenal failureSuicideUpper respiratory tract infections ePublished: 5 December 2000 Issue Published: 5 December 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...