tbuckley/cabot-search huggingface dataset:
Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission
Authors: Nicole M.F. van Gerven, Bart J. Verwer, Birgit I. Witte, Bart van Hoek, Minneke J. Coenraad, Karel J. van Erpecum, Ulrich Beuers, Henk R. van Buuren, Rob A. de Man, Joost P.H. Drenth, Jannie W. den Ouden, Robert C. Verdonk, Ger H. Koek, Johannes T. Brouwer, Maureen M.J. Guichelaar, Chris J.J. Mulder, Karin M.J. van Nieuwkerk, Gerd Bouma
Journal: Journal of Hepatology (2012)
Epithelial-Specific Methylation Marker: A Potential Plasma Biomarker in Advanced Non-small Cell Lung Cancer
Authors: Chanida Vinayanuwattikun, Virote Sriuranpong, Suebpong Tanasanvimon, Poonchavist Chantranuwat, Apiwat Mutirangura
Journal: Journal of Thoracic Oncology (2011)
A piece of my mind. Midnight visiting hour
Authors: S. H. Miles
Journal: JAMA (1989)

There are many kinds of darkness in the hospital. There are the inner darknesses of fear, despair, and sadness. There is the enveloping darkness of unspoken troubles. There is uncertainty and incomplete knowledge, the darknesses inherent in medical science. To patients, medical care itself is often shrouded in darkness, just as patients' and families' lives are dark to us. There is the quiet darkness of the ward at midnight where luminous insights are kindled from the flint of life's preciousness and the tinder of its mortality. My grandmother Elsie is 96. She rules four generations as an empress whose powers are constitutionally limited though her herald still speaks with ancient authority. The calls come at night: another fall, a bloody stool, a sigmoidoscopy, an ulcerated ischemic colon. Her son and her daughter arrive in the early afternoon. As she has in the past, she declines surgery and repeats her wish
Obama administration wins first appeal court ruling on health reform
Authors: J. H. Tanne
Journal: BMJ (2011)

The US Sixth Circuit Court of Appeals in Cincinnati, Ohio, ruled on 29 June that the US health reform act was constitutional, including the requirement that from 2014 most citizens buy health insurance.

It was the first appeals court ruling on the law, which has been challenged in 26 lawsuits in lower courts. Some of the lower courts’ rulings have supported the health reform act, while others have ruled it unconstitutional.

The health reform act, known as the Affordable Care Act, was passed in March 2010. It requires most US citizens to purchase health insurance in 2014 or …
Brachial Plexus Neuropathy
Authors: Edward R. Wolpow
Journal: JAMA (1975)

Two patients had acute, self-limiting, unilateral brachial plexus neuropathy in association with desensitizing subcutaneous injections of extracts of dusts and molds. Diminution of pain and return of function of the affected limb followed a short course of prednisone therapy, although a beneficial effect of the steroid cannot be considered proved. There is a large variety of antigenic substances already known to produce neuropathy following intramuscular injection; desensitizing antiallergy injections should be added to this list. (<i>JAMA</i>234:620-621, 1975)
GMC drops fresh misconduct charges against GP who ran out-of-hours service
Authors: C. Dyer
Journal: BMJ (2014)

The General Medical Council has dropped new misconduct charges against Ravi Sondhi, who ran an out-of-hours GP service in south London, on the eve of a week long hearing. Lawyers who represent doctors appearing before the Medical Practitioners Tribunal Service said it was highly unusual for a case to be dropped the afternoon before the hearing was due to start.

Sondhi was previously suspended for nearly four years. He faced a string of charges relating to the Croydoc service, which provided out-of-hours care in south London. The charges included taking unauthorised money advances from the service and failing to provide good clinical care because he was …
How do cultural variations emerge from universal mechanisms?
Authors: Douglas T. Kenrick, Jill M. Sundie
Journal: Behavioral and Brain Sciences (2005)

Diverse cultural norms governing economic behavior might emerge from a dynamic interaction of universal but flexible predispositions that get calibrated to biologically meaningful features of the local social and physical ecology. This impressive cross-cultural effort could better elucidate such gene-culture interactions by incorporating theory-driven experimental manipulations (e.g., comparing kin and non-kin exchanges), as well as analyses of mediating cognitive processes.
Purified Duck Embryo Rabies Vaccine
Authors: K. E. Nelson, V. Vithayasai, S. Makornkawkayoon, M. D. Batt, K. Panas-amporn, J. T. Anderson
Journal: JAMA (1977)

Seroconversion and adverse reaction rates were studied in 92 persons given four or five doses in a two-week period of duck embryo rabies vaccine (DEV) or duck embryo rabies vaccine purified by ultracentrifugation (P-DEV). Mouse-neutralizing antibodies developed in 78 of 92 (84.8%) persons in these accelerated schedules. There were no significant differences in the frequency of antibody conversion or in geometric mean titers of antibody between persons given either vaccine. However, local and systemic adverse reactions were substantially less common with P-DEV. These data suggest that four or five doses of DEV or P-DEV given in a two-week course can be used for preexposure prophylaxis in situations where the more drawn-out regimens would result in continuation of a high-risk of rabies exposure. The antibody response of persons given this more accelerated regimen must be determined. (<i>JAMA</i>238:218-220, 1977)
Delayed liver regeneration in peroxisome proliferator-activated receptor-α-null mice
Authors: Steven P. Anderson, Lawrence Yoon, Erika B. Richard, Corrie S. Dunn, Russell C. Cattley, Christopher J. Corton
Journal: Hepatology (2002)

Peroxisome proliferator chemicals, acting via the peroxisome proliferator-activated receptor-α ( Pparα ), are potent hepatic mitogens and carcinogens in mice and rats. To test whether Pparα is required for hepatic growth in response to other stimuli, we studied liver regeneration and hepatic gene expression following partial hepatectomy (PH) of wild-type and Pparα -null mice. Pparα -null mice had a 12- to 24-hour delay in liver regeneration associated with a delayed onset and lower peak magnitude of hepatocellular DNA synthesis. Furthermore, these mice had a 24-hour lag in the hepatic expression of the G 1 /S checkpoint regulator genes Ccnd1 and cMyc and increased expression of the IL-1β cytokine gene. Hepatic expression of Ccnd1 , cMyc , IL-1r1 , and IL-6r was induced in wild-type mice, but not Pparα -null mice, after acute exposure to the potent Pparα agonist Wy-14,643, indicating a role for Pparα in regulating the expression of these genes. Expression of the fatty acid ω-hydroxylase gene Cyp4a14 , a commonly used indicator gene for Pparα activation, was strongly induced in wild-type mice after hepatectomy, suggesting that altered hepatocyte lipid processing may also contribute to the impaired regeneration in mice lacking the Pparα gene. In conclusion, liver regeneration in Pparα -null mice is transiently impaired and is associated with altered expression of genes involved in cell cycle control, cytokine signaling, and fat metabolism. (Hepatology 2002;36:544-554.)
Prolonged Exposure to Sublingual Immunotherapy Improves Safety of Oral Immunotherapy
Authors: S. Seopaul, C.A. Keet, P.A. Frischmeyer-Guerrerio, A. Thyagarajan, J.T. Schroeder, R. Hamilton, S. Boden, P. Steele, S. Driggers, A.W. Burks, R.A. Wood
Journal: Journal of Allergy and Clinical Immunology (2012)
Suspected Acute Cholecystitis Comparison of Hepatobiliary Scintigraphy Versus Ultrasonography
Authors: J E FREITAS, S H MIRKES, D M FINK-BENNETT, R L BREE
Journal: Clinical Nuclear Medicine (1982)

One hundred ninety-fine patients with suspected acute cholecystitis (AC) underwent both hepatobiliary scintigraphy (HBS) and static gray-scale ultrasonography (US) to assess the relative value of each imaging modality in this clinical setting. HBS was performed after the intravenous injection of 5 mCi Tc-99m iprofenin. Abnormal HBS indicative of AC visualized the common bile duct, but not the gallbladder, within 1 to 4 hours after tracer administration. Abnormal US indicative of AC demonstrated cholelithiasis and/or gallbladder wall edema. In this series, HBS surpassed US in sensitivity (98.3% versus 81.4%), specificity (90.2% versus 60.2%), predictive value of an abnormal test (91.4% versus 51.6%), and predictive value of a normal test (100% versus 92%), HBS should be the procedure of choice for the rapid detection of AC.
Uptake of 99mTc-Pyrophosphate in Liver Necrosis
Authors: RENE A. ECHEVARRIA, CAROL BONANNO, DAVID K. DAVIS
Journal: Clinical Nuclear Medicine (1977)

The liver was visualized on a routine bone scan performed with 99mTc-pyrophosphate. There was laboratory evidence of liver cell necrosis and this was confirmed at autopsy a week later. The radionuclide is thought to have been taken up by the necrotic liver cells. The possibility that the necrotic liver may be consistently visualized by bone-seeking radionuclides deserves further exploration.
Evaluation of dextrose 50 % as a medium for injection-assisted polypectomy
Authors: S. Varadarajulu, A. Tamhane, R. Slaughter
Journal: Endoscopy (2006)

Background and study aims: Injection-assisted polypectomy (IAP) is traditionally carried out by using normal saline as the submucosal fluid cushion. However, normal saline, being isotonic, does not maintain the elevation of the mucosa for prolonged periods. It was hypothesized that dextrose 50 %, as a hypertonic solution, might be an ideal medium for IAP. This study evaluated the efficacy and safety of dextrose 50 % for performing IAP. Patients and methods: All patients undergoing IAP during gastroscopy or colonoscopy were randomly assigned on a prospective basis to receive either normal saline or dextrose 50 % as the submucosal fluid cushion. The endoscopist was blinded to the type of solution injected. The volume of solution and number of sites injected to elevate the lesion, the number of times IAP was interrupted to inject more fluid to maintain elevation, the rates of en bloc and complete resections, and the complication rates were compared in the two groups. The mean follow-up period was 10 months. Results: Fifty-two sessile lesions were removed in 50 patients. In comparison with normal saline, smaller volumes (median 7 ml vs. 5 ml; P = 0.02) and fewer injections (median 2 vs. 1; P = 0.003) were required to perform IAP when dextrose 50 % was used. The en bloc resection rate was higher with dextrose 50 % than with normal saline (82 % vs. 44 %; P = 0.01). Elevation of the submucosal area persisted even after completion of IAP in 96 % of the patients randomly assigned to dextrose 50 %, compared with 20 % of those receiving normal saline (P < 0.001). There were no significant differences in the rates of complete resection or complications between the two groups. Conclusions: Dextrose 50 % is superior to normal saline as a submucosal fluid cushion, as it allows better en bloc resection during injection-associated polypectomy.
TCTAP A-170 Efficacy of Everolimus-eluting Stent Implantation in Patients with Small Coronary(≦2.5mm) Arteries: Outcomes of 2-year Clinical Follow-up
Authors: Wataru Koguchi, Hideki Yano, Yoshimasa Shibata, Shigeo Horinaka, Mayuko Ishikawa, Toshihiko Ishimitsu
Journal: Journal of the American College of Cardiology (2014)
Influence of non-inherited maternal HLA antigens on occurrence of rheumatoid arthritis
Authors: R.R.P. de Vries, J. D'Amaro, G.M.Th. Schreuder, F.H.J. Claas, J.J. van Rood, S. ten Wolde, F.C. Breedveld, P. Rubinstein
Journal: The Lancet (1993)
Acute brucellosis with unexpected source.
Authors: B T Rogers, P M Keir, W G Henderson
Journal: BMJ (1974)

Acute brucellosis is uncommon in a wholly urban setting in the United Kingdom.We report here a case of pyrexia of unknown origin which appeared unlikely at first to be brucellosis but in which proof of this diagnosis was obtained by isolation of Brucella abortus from blood culture and positive serological results.
Hypokalemia and Arrhythmias in Myocardial Infarction
Authors: Erich H. Loewy
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The article on thiazide-induced hypokalemia by Martin Duke, MD (239:43, 1978), was interesting. It has seemed obvious to me for some time that the use of diuretics of the thiazide type, and to a lesser degree of the loop type, is filled with the danger of hypokalemia. Certainly the literature amply attests to this. The routine use of potassium supplements or of potassium-sparing agents has been found unnecessary in the routine case by many authorities. Nevertheless, I always have believed that in treating hypertension, or for that matter most edematous states, we are dealing with a population group especially susceptible to, and having a high instance of, acute myocardial infarction. Treating this group for hypokalemia after their arrival in the emergency room seems rather late, and it is not impossible that the prehospital mortality from ventricular fibrillation could be substantially reduced if the patients' potassium levels were kept
C1-02: Randomized Phase II study of vandetanib alone or in combination with carboplatin and paclitaxel as 1st-line treatment for advanced NSCLC
Authors: Bruce E. Johnson, Luis Paz-Ares, Filippo De Braud, Martin Sebastian, David J. Stewart, Wilfried Eberhardt, Annetta Krebs, Peter Langmuir, Roy S. Herbst, John V. Heymach
Journal: Journal of Thoracic Oncology (2007)
The Costs of HIV Infections
Authors: Carl M. Harris
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Arno et al<sup>1</sup>estimate a cost of approximately $5 billion (1989 dollars) for a prospective program of early intervention involving antiretroviral treatment and<i>Pneumocystis carinii</i>pneumonia prophylaxis for human immunodeficiency virus (HIV) pre— acquired immunodeficiency syndrome (AIDS) seropositive patients in the United States. We would like to raise some questions about the validity of two aspects of the authors' calculations, namely, the decline in caseloads for 1989 through 1991 and the adoption of a 50% access-to-treatment level. The General Accounting Office, in its June 1989 report entitled "AIDS Forecasting," analyzed 13 national forecasts of HIV/AIDS and asserted that a common deficiency of all forecasts was underestimation of the numbers of AIDS cases being projected; a conclusion reached in that report was that most forecasts needed adjustment upward by 50% to compensate for various forms of systematic undercounting. The growth in cumulative AIDS cases is the most
Pesticide safety among farmworkers: perceived risk and perceived control as factors reflecting environmental justice.
Authors: Thomas A Arcury, Sara A Quandt, Gregory B Russell
Journal: Environmental Health Perspectives (2002)

Farmworkers in the United States constitute a population at risk for serious environmental and occupational illness and injury as well as health disparities typically associated with poverty. Pesticides are a major source of occupational injury and illness to which farmworkers are exposed. Efforts to provide safety training for farmworkers have not been fully evaluated. Based on the Health Belief Model, this analysis examines how safety information affects perceived pesticide safety risk and control among farmworkers and how perceived risk and control affect farmworker knowledge and safety behavior. Data are based on interviews conducted in 1999 with 293 farmworkers in eastern North Carolina as part of the Preventing Agricultural Chemical Exposure in North Carolina Farmworkers' Project. Perceived pesticide risk and perceived pesticide control scales were developed from interview items. Analysis of the items and scales showed that farmworkers had fairly high levels of perceived risk from pesticides and perceived control of pesticide safety. Receiving information about pesticide safety (e.g., warning signs) reduced perceived risk and increased perceived control. Pesticide exposure knowledge was strongly related to perceived risk. However, perceived risk had a limited relationship to safety knowledge and was not related to safety behavior. Perceived control was not related to pesticide exposure knowledge, but was strongly related to safety knowledge and safety behavior. A key tenet of environmental justice is that communities must have control over their environment. These results argue that for pesticide safety education to be effective, it must address issues of farmworker control in implementing workplace pesticide safety.
Remitting Seronegative Symmetric Synovitis with Pitting Edema: Scintigraphic and Magnetic Resonance Imaging Findings
Authors: Takashi Takeguchi, Yoshifumi Sugawara, Keiichi Kikuchi, Hitoshi Miki, Teruhito Mochizuki, Junpei Ikezoe, Eiji Sada, Hitoshi Hasegawa, Masako Seike
Journal: Clinical Nuclear Medicine (2003)

Remitting seronegative symmetric synovitis with pitting edema (RS3PE) was first reported by McCarty et al in 1985 and refers to a rheumatologic set of symptoms with acute onset, with no erosive bone lesions, with seronegative findings, affecting the elderly more frequently, and showing an excellent prognosis with low-dose steroid therapy. Although these characteristics make it possible to differentiate it from rheumatoid arthritis and rheumatic polymyalgia, there have been very few reports on the imaging findings. The authors present scintigraphic and magnetic resonance images in a case of RS3PE.
Rare Case of Cardiac Hemangioma Causing Massive Pericardial Effusion
Authors: Soji Nishio, Kunihiko Kosuga, Senri Miwa, Yasue Fujiwara, Kazuhiko Katsuyama, Tatsuhiko Hata, Masaharu Okada, Yuzo Takeuchi, Shinsaku Takeda, Yasutaka Inuzuka, Junya Seki, Eiji Takeuchi, Tsuyoshi Terashima, Shigeru Ikeguchi
Journal: Circulation (2015)
Clinical Pharmacology of Oral Antidiabetic Agents
Authors: Jan Koch-Weser, Shiao-Wei Shen, Rubin Bressler
Journal: New England Journal of Medicine (1977)

The oral hypoglycemic agents available in the United States (Fig. 1) include the sulfonylureas tolbutamide (Orinase), chlorpropamide (Diabinese), acetohexamide (Dymelor), tolazamide (Tolinase) and the biguanide phenformin hydrochloride (DBI, DBI-TD).Since the clinical introduction of oral hypoglycemic agents 20 years ago, a large number of diabetic patients have been treated with these drugs, and much animal experimentation has been carried out. With the publication of the results of the controversial University Group Diabetes Program (UGDP), questions have been raised regarding the use of oral hypoglycemic agents. This review will in part address itself to this problem.Sulfonylureas and PhenforminPharmacology Absorption . . .
The Latex Agglutination and Inhibition Reactions
Authors: Arthur P. Hall, Alma D. Mednis, Theodore B. Bayles
Journal: New England Journal of Medicine (1958)

C INCE the observation by Cecil et al.,1 in 1930, that ^ serum from patients with rheumatoid arthritis would agglutinate certain strains of streptococci, and by Waaler,2 in 1940, that such serums would also agglutinate sheep cells sensitized with rabbit antisheep-cell serum, it has become clear that serums from rheumatoid patients contain a factor (or factors) that is either absent or present in minimal amounts in the serums of normal persons. The presence of such a factor has been demonstrated not only by a variety of serologic indicator systems but also by paper chromatography,3 ion-exchange chromatography4 and the ultracentrifuge.5 Although . . .
Epithelial dysplasia in Caroli's disease.
Authors: N I Walker, R W Strong
Journal: Gut (1990)

SIR, -The comments of Drs Colombel, Janin, and Torpier are of interest.We agree that the immune processes which may contribute to the mucosal lesion of coeliac disease may be multifactorial.The eosinophil is a major com- ponent of the inflammatory infiltrate in coeliac disease, although this is frequently not emphasised in descriptions of the lesion.We have recently produced additional evidence that eosinophils and polymorphs are present in increased numbers in the coeliac mucosa: using monoclonal antibodies to Fc receptors (for the gamma chain of IgG) types II and III, which are found on eosinophils and polymorphs, a marked increase in reactive cells was found.The evidence of Dr Colombel and colleagues that many of these eosinophils have degranulated and the associated finding of increased release of granule components points to mech- anisms whereby eosinophils might mediate damage.The possibility that IgA, produced in large quantities in the damaged intestine, may be involved in eosinophil degranulation through interaction with IgA Fc receptors should also be considered.The finding that many coeliac patients react rapidly to gluten challenge (both symptomatically and histologically) is in keeping with more immediate mechanisms of damage also participating in the development of the lesion.Eosinophils are good candidates for such a mechanism.
Molecular characterization of β-thalassemia genes in an Argentine population
Authors: Ariel Roldán, Marina Gutiérrez, Ana Cygler, Mariana Bonduel, Gabriela Sciuccati, Aurora Feliu Torres
Journal: American Journal of Hematology (1997)

This study was designed to identity the β-thalassemia mutations in an Argentine population. Seventy-one pediatric patients and 101 available relatives were studied (85 chromosomes). Diagnosis of β-thalassemia was made by conventional hematological procedures. Molecular studies were carried out by dot-blot and restriction endonuclease analysis on amplified DNA to detect the eight most frequent mutations in the Mediterranean area. We were able to identify 95.3% of the β-thalassemia mutations in the subjects under study. The four common defects (C-39, 47%; IVS-I nt 110, 22.4%; IVS-I nt 1, 9.4%; and IVS-I nt 6, 5.9%) account for 84.7% of the β-thalassemia alleles. The alleles and their distributions showed a close similarity to the spectrum of alleles in Italy. The differences might represent the influence of other immigrations, especially from Spain. We conclude that β-thalassemia in Argentina originated mainly from Italian immigrants. This study will enable us to design an adequate approach to genetic counseling and/or prenatal diagnosis for couples at risk. Am. J. Hematol. 54:179–182, 1997 © 1997 Wiley-Liss, Inc.
Circle of Light
Authors: Narda Lyn Butler
Journal: JAMA (1996)

Into the dark night, we pile out of the back of the van en masse. I have joined this group of national volunteers primarily out of curiosity. The specific skills for which I was hired are important for the treatment of disease but are not integral for this part of the research project. The volunteer ranks have swelled since the acquisition of an air-conditioned vehicle. Words of another language are tossed into the air, and there is much laughter. "Flash, flash!" Words in English! A box is brought forth, followed quickly by the distinct clicks of flashlights illuminating. Specimen-collection materials are gathered and distributed. The large fluorescent light ingeniously attached to a battery is lit. We follow the circle of light off the dirt road and onto a dusty footpath. The quiet, rhythmic rustle of sugar cane leaves accompanies our trek into another world: the research site. The sky is
Basic questions on toxicology and pharmacology of anthralin
Authors: H. IPPEN
Journal: British Journal of Dermatology (1981)

Journal Article Basic questions on toxicology and pharmacology of anthralin Get access H. IPPEN H. IPPEN Universitätshautklinik, v. Siebold‐Strasse 3, D‐3400 Göttingen, W. Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s20, 1 August 1981, Pages 72–76, https://doi.org/10.1111/j.1365-2133.1981.tb01015.x Published: 01 August 1981