tbuckley/cabot-search huggingface dataset:
Follicular lymphoma: A model of lymphoid tumor progression in man
Authors: Andrew D. Zelenetz, Michael J. Campbell, David W. Bahler, Shuji Takahashi, Rachel Oren, Laura Esserman, Dale T. Umetsu, Larry W. Kwak, David G. Maloney, Sherri Brown, Thomas T. Chen, Matthew L. Andria, Shoshana Levy, Richard A. Miller, Ronald Levy
Journal: Annals of Oncology (1991)
Mismatched marrow grafts succeed thanks to two anti-T-cell agents
Authors: Beverly Merz
Journal: JAMA (1983)

The A. he patient died, but—the old story—the therapy was a success. Indeed, an Associated Press story heralded the treatment as a major medical break-through. The story, which hit newsstands across the nation on February 15, began hyperbolically, "For the first time, doctors have cured a deadly assault on the body's immune system, saving the life of a week-old baby with an experimental treatment called monoclonal antibodies." The article was referring to the treatment of Bryan Ahlers, who during surgery to repair a heart defect three days after his birth at Children's Hospital, Buffalo, NY, was given a routine blood transfusion. When rash, fever, diarrhea, and ascites developed, immunologist Byung H. Park, MD, recognized the classic symptoms of graft<i>v</i>host disease (GVHD). This seemed an unlikely response until physicians discovered that Bryan had no thymus. With no mature T lymphocytes of his own, the lymphocytes in the transfused blood
THE EFFECT OF VARIOUS TISSUE EXTRACTS UPON THE GROWTH OF ADULT MAMMALIAN CELLS IN VITRO
Authors: Albert J. Walton
Journal: The Journal of Experimental Medicine (1914)

The cultivation of cells in vitro affords a valuable means of estimating the effects of tissue extracts. Tissue extracts have a definite effect upon the growth of adult mammalian cells in vitro. The majority of tissue extracts stimulate the growth of connective tissue, but liver extract inhibits it. The extracts are to a certain extent specific in their action upon the growth of parenchymatous cells. Some cells are stimulated by one extract and inhibited by another, and those extracts which inhibit one type of parenchymatous cell may stimulate another type. Homogenous and autogenous extracts are equally efficacious in their action upon the growth of cells. The extracts may be preserved for a short period of time without suffering any change in their power of affecting the growth of cells.
Using Standardized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate
Authors: Andrew S. Levey, Josef Coresh, Tom Greene, Lesley A. Stevens, Yaping (Lucy) Zhang, Stephen Hendriksen, John W. Kusek, Frederick Van Lente
Journal: Annals of Internal Medicine (2006)

Background: Glomerular filtration rate (GFR) estimates facilitate detection of chronic kidney disease but require calibration of the serum creatinine assay to the laboratory that developed the equation. The 4-variable equation from the Modification of Diet in Renal Disease (MDRD) Study has been reexpressed for use with a standardized assay. Objective: To describe the performance of the revised 4-variable MDRD Study equation and compare it with the performance of the 6-variable MDRD Study and Cockcroft–Gault equations. Design: Comparison of estimated and measured GFR. Setting: 15 clinical centers participating in a randomized, controlled trial. Patients: 1628 patients with chronic kidney disease participating in the MDRD Study. Measurements: Serum creatinine levels were calibrated to an assay traceable to isotope-dilution mass spectrometry. Glomerular filtration rate was measured as urinary clearance of 125I-iothalamate. Results: Mean measured GFR was 39.8 mL/min per 1.73 m2 (SD, 21.2). Accuracy and precision of the revised 4-variable equation were similar to those of the original 6-variable equation and better than in the Cockcroft–Gault equation, even when the latter was corrected for bias, with 90%, 91%, 60%, and 83% of estimates within 30% of measured GFR, respectively. Differences between measured and estimated GFR were greater for all equations when the estimated GFR was 60 mL/min per 1.73 m2 or greater. Limitations: The MDRD Study included few patients with a GFR greater than 90 mL/min per 1.73 m2. Equations were not compared in a separate study sample. Conclusions: The 4-variable MDRD Study equation provides reasonably accurate GFR estimates in patients with chronic kidney disease and a measured GFR of less than 90 mL/min per 1.73 m2. By using the reexpressed MDRD Study equation with the standardized serum creatinine assay, clinical laboratories can report more accurate GFR estimates. *For a list of investigators of the Chronic Kidney Disease Epidemiology Collaboration, see the Appendix.
Extrahepatic Manifestations of Hepatitis C Virus Infection
Authors: Francesco Turturro
Journal: Annals of Internal Medicine (1996)

Letters15 August 1996Extrahepatic Manifestations of Hepatitis C Virus InfectionFrancesco Turturro, MD, Denise M. Tritz, MD, and Michael Doukas, MDFrancesco Turturro, MDUniversity of Kentucky Medical Center and Veterans Affairs Medical Center, Lexington, KY 40536Search for more papers by this author, Denise M. Tritz, MDUniversity of Kentucky Medical Center and Veterans Affairs Medical Center, Lexington, KY 40536Search for more papers by this author, and Michael Doukas, MDUniversity of Kentucky Medical Center and Veterans Affairs Medical Center, Lexington, KY 40536Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-4-199608150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:One of the extrahepatic manifestations of HCV infection outlined in the review by Gumber and Chopra [1] is the link between HCV infection and essential mixed cryoglobulinemia and the speculation that the former is an etiologic agent of the latter. We and other researchers agree that HCV may be an important etiologic agent of monoclonal gammopathies. Accordingly, we report an interesting case that we recently encountered.A 47-year-old woman was admitted to the renal service at our institution because of progressive deterioration of renal function, which necessitated hemodialysis. Our hematology service was consulted for work-up of thrombocytopenia. ...References1. Gumber SC, Chopra S. Hepatitis C: a multifaceted disease. Review of extrahepatic manifestations. Ann Intern Med. 1996; 123:615-20. Google Scholar2. Santini GF, Crovatto M, Modolo ML, Martelli P, Ceselli S. Waldenstrom macroglobulinemia: a role of HCV infection? [Letter]. Blood. 1993; 82:2932. Google Scholar3. Ferri C, La Civita L, Longombardo G, Lombardini F, Pasero G, Zignego Al, et al. Hepatitis C virus in mixed cryoglobulinemia and B cell lymphoma [Letter]. Clin Exper Rheumatol. 1994; 12:89-96. Google Scholar4. Mussini C, Ghini M, Mascia MT, Giovanardi P, Zanni G, Lattuada I, et al. Monoclonal gammopathies and hepatitis C virus [Letter]. Blood. 1995; 85:1144-5. Google Scholar5. Isobe T, Osserman EF. Pathologic conditions associated with plasma cell dyscrasia. A study of 806 cases. Ann NY Acad Sci. 1971; 190:507-18. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Kentucky Medical Center and Veterans Affairs Medical Center, Lexington, KY 40536 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1996Volume 125, Issue 4Page: 345-346KeywordsBone marrowInfectious hepatitisMegakaryocytesPolymerase chain reactionRNARaynaud syndromeResearch laboratoriesSerum albuminSerum proteinsSpleen Issue Published: 15 August 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Blowing In the Wind
Authors: Samuel Vaisrub
Journal: JAMA (1974)

The mind-blowing windorama unveiled in the<i>JAMA</i>editorial, "The Great Winds of the Earth" (227:195-196, 1974), is overawing, if not downright frightening. Apparently, the Hawaiian<i>kona</i>, the Tyrolean<i>foehn</i>, the North African<i>hamsin</i>and many other mighty winds exert an adverse effect on emotions and behavior, even on health. To such as these may well apply Shakespeare's "Ill blows the wind that profits nobody." Not all, however, is loss. There are other winds, soft and genial. "The gentle wind in the palm trees," "The Western breeze that blows kindly," and "every little breeze" that seemed to "whisper Louise" linger nostalgically in memory. And does not God "temper the wind to the shorn lamb"? "I had a sudden visual picture of myself" writes the noted columnist Stewart Alsop (<i>Saturday Rev World</i>, Dec 18, 1973, pp 20-23), a victim of leukemia, "as the shorn lamb, naked to the cold wind, and the
Abstract 5477: Gefitinib enhances arsenic trioxide (AS2O3)-induced differentiation of acute promyelocytic leukemia cell line
Authors: Eui-Kyu Noh, Hawk Kim, Min Jae Park, Jin Ho Baek, Jae-Hoo Park, Seung Joo Cha, Young Joo Min
Journal: Cancer Research (2010)

Abstract Gefitinib (Iressa, ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits growth, invasion and colony formation of various cancer cells. However, little is known about the effect of combination of gefitinib and arsenic trioxide (ATO) on differentiation of acute promyelocytic leukemia (APL). Therefore, we investigated whether gefitinib had any role in the ATO-induced differentiation of NB4 cells (APL cell line). Gefitinib induced the expression of differentiation markers including CD11b and CD14 in ATO-treated NB4 cells and facilitated ATO-induced morphologic changes and ROS generation. The results were evident that the combination of gefitinib and ATO could induce more effectively functional differentiation of leukemic cells to macrophage-like cells. Moreover, the extracellular-signal regulated kinase (ERK) pathway was necessary for the enhancement of gefitinib in ATO-induced differentiation, measured by CD11b and CD14 expression on NB4 cells. Therefore, our data indicated that gefitinib can play a potential role as an adjunctive differentiation agent in APL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5477.
Columbus' Voyage and Syphilis
Authors: Theodore James
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The medical notes on Columbus' first trip to America (236:1598, 1976), by their very nature, have interest for the inquiring mind and, naturally, where there is doubt, questions arise. One particular question that emerges fleetingly is related to the statement of Lopez that the discovery of America marks the finding of two items of medical significance. The first is tobacco, found by Columbus in Cuba during the first trip. The second is syphilis. Although the place of its origin is still argued, it is accepted by most that it came from America and that it was taken to Europe by Columbus's sailors on their return from the first trip. For this statement, Lopez cites three references. Lopez also mentions that "the note from Las Casas about sores in Navidad raises the possibility that some of the crew already had been affected with the disease at that time." However,
Multiple Myeloma and Multiple Neoplasms
Authors: Stephen M. Robins
Journal: JAMA (1976)

SIMULTANEOUS multiple primary neoplasms in a single individual are increasingly being recognized. Disordered immune surveillance might render patients to be unusually susceptible to the development of multiple tumors.<sup>1</sup>We report a patient with multiple myeloma who had at least three other primary neoplasms. <h3>Report of a Case</h3> An 83-year-old man had weight loss, bone pain, and anemia (hematocrit value, 22.7%). Protein electrophoresis showed a monoclonal spike in the gamma region. Immunoelectrophoresis demonstrated increased IgG levels (6.6 gm/100 ml) and decreased IgA and IgM levels. Urine immunoelectrophoresis showed an increased IgG level and lambda light chains. Bone marrow biopsy specimens showed a hypercellular marrow, with sheets of plasma cells comprising 50% of the cellular population. The serum calcium concentration was 12 mg/100 ml and serum phosphate and alkaline phosphatase levels were within normal limits. Stools were 4 + guaiac positive. The patient was treated with hydration, sodium biphosphate and a regimen
A Novel Sialic Acid Binding Site on Factor H Mediates Serum Resistance of Sialylated <i>Neisseria gonorrhoeae </i>
Authors: Sanjay Ram, Ajay K. Sharma, Scott D. Simpson, Sunita Gulati, Daniel P. McQuillen, Michael K. Pangburn, Peter A. Rice
Journal: The Journal of Experimental Medicine (1998)

Factor H (fH), a key alternative complement pathway regulator, is a cofactor for factor I–mediated cleavage of C3b. fH consists of 20 short consensus repeat (SCR) domains. Sialic acid binding domains have previously been localized to fH SCRs 6–10 and 13. To examine fH binding on a sialylated microbial surface, we grew Neisseria gonorrhoeae in the presence of 5′-cytidinemonophospho-N-acetylneuraminic acid, which sialylates lipooligosaccharide and converts to serum resistance gonococci previously sensitive to nonimmune serum killing. fH domains necessary for binding sialylated gonococci were determined by incubating organisms with recombinant human fH (rH) and nine mutant rH molecules (deletions spanning the entire fH molecule). rH and all mutant rH molecules that contained SCRs 16–20 bound to the sialylated strain; no mutant molecule bound to serum-sensitive nonsialylated organisms. Sialic acid was demonstrated to be the fH target by flow cytometry that showed a fourfold increase in fH binding that was reversed by neuraminidase-mediated cleavage of sialic acid off gonococci. Functional specificity of fH was confirmed by decreased total C3 binding and almost complete conversion to iC3b on sialylated gonococci. Sialic acid can therefore bind fH uniquely through SCRs 16–20. This blocks complement pathway activation for N. gonorrhoeae at the level of C3.
CARE AND USE OF INSTRUMENTS.
Authors: ALLEN DE VILBISS
Journal: JAMA (1901)

It is not my purpose to enter into a discussion of, or repeat what has been said and written on this subject, but to present a few thoughts that will indicate a way to care for and acquire the use of instruments along a line that will give the operator the kind of knowledge that will enable him to cope with exigencies that may arise. We should remember, after an operation, to put the instruments where they are perfectly dry and will remain so, to prevent rusting, and where the edges will be kept from being dulled by contact. Before an operation it is essential that the instrument should be sharp and clean. Boiling is unquestionably the best way to put them in this condition. The cutting edges are not spoiled by the heat, as is believed by some, but by a deposit of material upon the edge of the
Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150
Authors: Margherita Ghisi, Alberto Corradin, Katia Basso, Chiara Frasson, Valentina Serafin, Subhamoy Mukherjee, Lara Mussolin, Katia Ruggero, Laura Bonanno, Alessandro Guffanti, Gianluca De Bellis, Gino Gerosa, Giovanni Stellin, Donna M. D'Agostino, Giuseppe Basso, Vincenzo Bronte, Stefano Indraccolo, Alberto Amadori, Paola Zanovello
Journal: Blood (2011)
Livedoid vasculopathy: An in-depth analysis using a modified Delphi approach
Authors: Afsaneh Alavi, Jürg Hafner, Jan P. Dutz, Dieter Mayer, R. Gary Sibbald, Paulo Ricardo Criado, Patricia Senet, Jeffery P. Callen, Tania J. Phillips, Marco Romanelli, Robert S. Kirsner
Journal: Journal of the American Academy of Dermatology (2013)
The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia
Authors: Darrell J. Triulzi, Susan F. Assmann, Ronald G. Strauss, P. M. Ness, John R. Hess, Richard M. Kaufman, Suzanne Granger, Sherrill J. Slichter
Journal: Blood (2012)
Abstract 2653: Racial and ethnic differences in survival after cancer diagnosis
Authors: Andrew J. Lovy, Richard G. Gorlick, David S. Geller
Journal: Cancer Research (2012)

Abstract Introduction: Racial differences in cancer survival have been well established based on national and independent cancer registries. Multiple extrinsic factors including stage, socioeconomic status (SES) and treatment have been postulated as causative, questioning whether race is a significant independent predictor of cancer survival. The purpose of this study was to evaluate racial differences in overall cancer survival rates in a diverse NY population. Methods: Study population included 18,556 patients (28% White, 31% African American (AA), 27% Hispanic) diagnosed and/or treated for primary cancer from 1/1/2000 through 1/1/2007 at Montefiore Medical Center (MMC), identified through MMC's Cancer Registry. Demographics, clinical information and survival were obtained through the Cancer Registry. SES was determined using census tract data. Kaplan-Meier survival curves and Cox proportional hazards regression were used to compare overall survival by race. Results: White patients were older (67.6 vs. 60.9 &amp; 58.7) and of higher SES than AA and Hispanic patients, with similar rates of stage III/IV cancer and surgical treatment. Unadjusted analysis revealed that Whites had a significantly higher risk of death compared to all other patients (HR 1.29, 95%CI 1.23-1.35). Adjusting for age, sex, stage at diagnosis, surgical treatment and SES in all cancer types combined, revealed a significantly higher risk of death compared to all other patients (HR 1.14, 95%CI 1.06-1.21). However, race was no longer a significant predictor of cancer survival in multivariate models stratified by cancer type. Conclusion: Contrary to published literature, White patients had significantly lower survival rates than AA and Hispanic patients in unadjusted models. Racial differences in cancer survival diminished in adjusted models, and were absent when stratifying by cancer type. These results suggest that racial disparities in cancer survival may be better explained by variables such as age, stage at presentation, SES, treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2653. doi:1538-7445.AM2012-2653
Discoid lupus erythematosus-like lesions in an autosomal form of chronic granulomatous disease
Authors: J.F. STALDER, B. DRENO, B. BUREAU, J. HAKIM
Journal: British Journal of Dermatology (1986)

Chronic granulomatous disease (CGD) is characterized by a bactericidal defect involving the oxidative metabolism of polymorphonuclear leukocytes (PML) and is most often transmitted as an X-linked trait. The cutaneous features of this disorder include infections and lupus-like rashes. These have been described in female carriers as well as in males with the disease. Two cases of siblings presenting an autosomal form of CGD syndrome, with lupus-like cutaneous manifestations, are reported here.
Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum.
Authors: C L Scudamore, E M Thornton, L McMillan, G F Newlands, H R Miller
Journal: The Journal of Experimental Medicine (1995)

The soluble granule chymase, rat mast cell protease-II (RMCP-II), is abundantly expressed in intestinal mucosal mast cells (MMC) but its function is not known. One hypothesis is that RMCP-II degrades the epithelial basement membrane and promotes the loss of enterocytes typically associated with type I hypersensitivity reactions in the rat. To test this hypothesis more directly, ex vivo perfusion of the cranial mesenteric artery and jejunal lumen was used to monitor the anaphylactic release of RMCP-II and its effects on mucosal permeability and epithelial integrity. Within 2 min of intravascular challenge with soluble adult Nippostrongylus brasiliensis worm antigen there was a 1,000-fold (P &amp;lt; 0.02) increase in the concentration of RMCP-II in the vascular perfusate from the jejunum of Nippostrongylus-sensitized rats but not the controls. Similarly, translocation of RMCP-II into the gut lumen increased 10-fold (P &amp;lt; 0.02) after 2 min only in worm antigen-challenged immune rats. Using an identical protocol, but incorporating Evans blue-labeled human serum albumin (EB-HSA) in the vascular perfusate, the timing of the release of RMCP-II into the two compartments was very similar to the first experiment and furthermore the translocation of EB-HSA increased 18-fold (P &amp;lt; 0.05) after 4 min in sensitized rats challenged with worm antigen. To examine the effects of RMCP-II more directly 1 mg of the highly purified chymase was introduced into the cranial mesenteric artery in ex vivo perfused normal rats. A significant (P &amp;lt; 0.05) 70-fold increase in concentration of RMCP-II in jejunal perfusate occurred after 6 min. In a repeat dose-response experiment, infusion of 0.375, 0.75, or 1.5 mg of RMCP-II, together with EB-HSA, established that the cumulative amounts of RMCP-II and EB-HSA translocated from the vasculature to the gut lumen in each perfusion (during the 10-min period of RMCP-II infusion) were significantly correlated. Analysis of intestinal perfusates by SDS-PAGE and by Western blotting using monoclonal anti-RMCP-II antibody confirmed that there was a concomitant translocation of both the protease and EB-HSA into the gut lumen. Histological evaluation of the mucosa failed to reveal any significant morphological change in any of the experiments. The rapid development of macromolecular leak, its association with the translocation of RMCP-II, and the absence of gross epithelial lesions, suggest for the first time that a mast cell granule chymase increases epithelial permeability via a paracellular route and implies that the substrate may be a protein, or proteins, in the epithelial junctional complex.
Case of Lipoid Proteinosis
Authors: M. A. Cowan, S. Alexander, H. R. Vickers, R. H. Cowdell
Journal: BMJ (1961)

Lipoid proteinosis (Urbach-Wiethe disease; hyalinosis cutis et mucosae) is a rare and striking disorder in which there is a peculiar infiltration of the skin and mucous membrane.Siebenmann (1908) described a case of " ichthyosiform disease " in a 19-year-old girl under the subtitle of " hyperkeratosis cutis universalis, keratosis oris, linguae, labiorum, palati duri et mollis,
Psoriasis management: considerations in women of childbearing age
Authors: S. Davies, A.Y. Finlay
Journal: British Journal of Dermatology (2006)

Journal Article Psoriasis management: considerations in women of childbearing age Get access S. Davies, S. Davies Department of Dermatology, Wales College of Medicine, Cardiff University, CF14 4XN, U.K Search for other works by this author on: Oxford Academic Google Scholar A.Y. Finlay A.Y. Finlay Department of Dermatology, Wales College of Medicine, Cardiff University, CF14 4XN, U.K A.Y. Finlay. E‐mail: Finlayay@cf.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 1, 1 July 2006, Page 228, https://doi.org/10.1111/j.1365-2133.2006.07308.x Published: 01 July 2006
TCT-301 Feasibility and Results of Novel Side Branch Evaluation by Reconstructed 3-Dimensional Optical Coherence Tomography. Matched Analysis of Baseline and 12-month follow-up in Native, Jailed and Opened Side Branches
Authors: Niels Holm, Shengxian Tu, Rasmus Christensen, Trine Ørhøj, Michael Maeng, Lars Krusell, Christian Terkelsen, Jouke Dijkstra, Anne Kaltoft, Steen Kristensen, Hans Erik Bøtker, Leif Thuesen, Jens Lassen, Johan Reiber, Evald Høj Christiansen
Journal: Journal of the American College of Cardiology (2012)