tbuckley/cabot-search huggingface dataset:
Characterization of the T‐cell epitopes of a major peanut allergen, Ara h 2
Authors: I. N. Glaspole, M. P. De Leon, J. M. Rolland, R. E. O'Hehir
Journal: Allergy (2004)

Background: The development of safe and effective immunotherapy for peanut allergy has been complicated by the high anaphylactic potential of native peanut extracts. We sought to map the T‐cell epitopes of the major peanut allergen, Ara h 2 in order to develop T‐cell targeted vaccines. Methods: A panel of eight peanut‐specific CD4+ T‐cell lines (TCL) was derived from eight peanut‐allergic subjects and proliferative and cytokine responses to stimulation with a set of overlapping 20‐mer peptides representing the entire sequence of Ara h 2 determined. Proliferation was assessed in 72 h assays via tritiated thymidine incorporation, while interleukin (IL)‐5 and interferon (IFN)‐ γ production were assessed via sandwich enzyme‐linked immunosorbent assay (ELISA) of cell culture supernatants. Results: Eight of the 17 Ara h 2 peptides were recognized by one or more subjects, with the two peptides showing highest reactivity [Ara h 2 (19–38) and Ara h 2 (73–92)] being recognized by three subjects each. Adjoining peptides Ara h 2 (28–47) and Ara h 2 (100–119) induced proliferative responses in two subjects. Each of these peptides was associated with a Th2‐type cytokine response. Conclusion: Two highly immunogenic T‐cell reactive regions of Ara h 2 have been identified, Ara h 2 (19–47) and Ara h 2 (73–119), providing scope for the development of safe forms of immunotherapy for peanut allergy.
Dermatoglyphics in Children with Acute Leukaemia
Authors: S. G. Purvis-Smith, M. A. Menser
Journal: BMJ (1973)

The dermatoglyphics of 135 children with acute leukaemia differed significantly from those of normal controls, and examination of 174 of the patients' first degree relatives indicated that familial factors were involved. The findings suggested that within the racial group studied dermatoglyphics may partly identify a population subgroup which is at increased risk of leukaemogenesis. While these observations may not have immediate clinical application, they are likely to contribute to a greater understanding of individuals who have increased constitutional susceptibility to leukaemia.
Impairment of forearm vasodilatation to acetylcholine in hypercholesterolemia is reversed by aspirin
Authors: J Noon
Journal: Cardiovascular Research (1998)

Objective: Impaired cholinergic vasodilatation in the forearm in hypertension and hypercholesterolemia has been attributed to impaired nitric oxide bioavailability. However, inhibition of cyclooxygenase reverses the impaired cholinergic dilatation in hypertensive animals and patients. The aim of this study was to examine the effect of aspirin on cholinergic vasodilatation in hypercholesterolemic patients. Methods: We examined responses to brachial artery infusion of acetylcholine and the endothelium-independent vasodilator sodium nitroprusside in the presence or absence of aspirin in 10 hypercholesterolemic patients (7 men/3 women; aged 38–63 yr; systolic blood pressure 133±5 mmHg; diastolic blood pressure 80±3) compared with 10 matched controls (7 men/3 women; aged 38–63 yr; systolic blood pressure 126±2; diastolic blood pressure 77±2). Results: In hypercholesterolemic patients, forearm vasodilatation was impaired in response to acetylcholine (112±20 vs. 346±30% increase in blood flow in controls, at the highest dose [15 μg min−1]; P<0.0001) but not in response to sodium nitroprusside. With the addition of aspirin, baseline forearm blood flow was unaltered. However, forearm vasodilatation to acetylcholine was partially restored in hypercholesterolemics (from 112±20 to 193±30%; P<0.001) though not affected in controls. Vasodilator responses to sodium nitroprusside were unaffected by aspirin in either group. Conclusions: In hypercholesterolemia, an altered balance between vasoconstrictor and dilator prostanoids, favouring constrictors, may contribute to endothelial dysfunction either directly or through an effect on nitric oxide synthesis. Restoration of this imbalance may be a component of the therapeutic benefit of aspirin in cardiovascular disease.
"Third drug" trial: comparative study of antihypertensive agents added to treatment when blood pressure remains uncontrolled by a beta blocker plus thiazide diuretic.
Authors: D McAreavey, L E Ramsey, L Latham, A D McLaren, A R Lorimer, J L Reid, J I Robertson, M P Robertson, R J Weir
Journal: BMJ (1984)

Hydralazine, labetalol, methyldopa, minoxidil, prazosin, and placebo were compared when added by random allocation to atenolol 100 mg and bendrofluazide 5 mg daily in a series of 238 hypertensive patients inadequately controlled by the beta blocker-diuretic combination. Atenolol was withdrawn in those allocated to labetalol, and minoxidil was given only to men. The order of acceptability was: placebo, hydralazine, prazosin, methyldopa, minoxidil, labetalol. Minoxidil was more effective than the other active drugs, which had similar potency to one another. All the active agents were more effective than placebo. Hydralazine was the most generally suitable third drug, with prazosin a close second. Minoxidil was especially effective in patients with less severe hypertension but the same regimen caused fluid retention in those with more severe disease. Labetalol should probably be introduced at a low dose (150 mg daily) even when replacing full doses of a previously administered beta blocker.
Reticulate pigmented anomaly of the flexures (Dowling, Degos): a new genodermatosis
Authors: E. Wilson Jones, K. Grice
Journal: British Journal of Dermatology (1974)

Journal Article Reticulate pigmented anomaly of the flexures (Dowling, Degos): a new genodermatosis Get access E. Wilson Jones, E. Wilson Jones St John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar K. Grice K. Grice St John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Page 36, https://doi.org/10.1111/j.1365-2133.1974.tb12503.x Published: 01 July 1974
Mosquitoes, Malaria and Man: A History of the Hostilities Since 1880
Authors: Lester S. King
Journal: JAMA (1978)

Malaria, well known since the time of Hippocrates, was one of the first diseases for which a specific remedy—quinine—became available, but not until the end of the 19th century did the inner mysteries of the disease, the details of its pathogenesis, become known. The hero was Ronald Ross, a strange character indeed, who in his early life gave no hint of future greatness. In this book Harrison provides a fascinating tableau of the achievement. Ross started with negligible preliminary training. However, encouraged by Patrick Manson, he was able to overcome environmental difficulties, government red tape, official muddleheadedness, and through unremitting determination he finally achieved his goal—to find the specific parasite and prove its causal involvement in the disease. Manson had emphasized that the mosquito was probably the vector, but there were many kinds of mosquitoes whose strict specificity, in regard to malaria, was not at first suspected. Then, too, the
Common Variable Immunodeficiency Syndrome and Nodular Lymphoid Hyperplasia in the Small Intestine
Authors: Christiane Bästlein, R. Burlefinger, E. Holzberg, Ch. Voeth, M. Garbrecht, R. Ottenjann
Journal: Endoscopy (1988)

We report on a case of nodular lymphoid hyperplasia (NLH) of the small intestine in a patient with common variable immunodeficiency (CVID) syndrome. The CVID syndrome comprises a group of heterogeneous immunological disorders. It is characterised by hypogammaglobulinemia, recurrent sinopulmonary infections, gastrointestinal disorders (including diarrhoa, infestation with Giardia lamblia, chronic-atrophic gastritis and nodular lymphoid hyperplasia (NLH), and an increased risk of malignancy. NLH is frequently associated with gastrointestinal lymphomas. It has also been found in the terminal ileum of children and in adult patients with Gardner's syndrome. NLH is found in about 20 % of patients with the CVID syndrome. The diagnosis of NLH requires endoscopic and bioptic-histological examinations and the determination of the immunoglobulins.
Will Centrifugal Forces Destroy the Medical Profession?
Authors: Walter W. Benjamin
Journal: New England Journal of Medicine (1989)

THE American Medical Association was born in the middle of the 19th century, when almost all physicians were general practitioners, virtually indistinguishable from one another. Now, with more than 100 specialties and subspecialties, the center of the medical profession is not holding. Aside from the M.D. degree, what do a psychiatrist and a pathologist have in common? A public health physician and an anesthesiologist? A specialist in nuclear medicine and an ophthalmologist?In years past, with medical knowledge expanding, everyone had enough to do that turf wars were minimal. Now, with medical supply exceeding demand, with nonmedical healers wanting to . . .
Credibility of Reporting of Malformations in Birth Certificates
Authors: Muriel Mackeprang
Journal: JAMA (1972)

<h3>To the Editor.—</h3> A comparison of the hospital records of newborns and matching birth certificates revealed that malformations of major severity were reported on certificates of birth more frequently than minor malformations. Easily recognized malformations were also more frequently reported than those less easily recognized. Certifying the birth of an infant is such a routinely accepted procedure that in most hospitals where deliveries occur, aides or clerks prepare the forms. The attending physician, who is legally responsible for preparing and filing certificates of birth, can be reasonably confident that the members of the clerical staff are competent to record necessary identifying data. The portion of the birth certificate on which medical information is requested is less easily delegated to others. While complications relating to maternal conditions are of less urgent public health concern today than they were at the time medical data were first requested on birth certificates, there still
Subclinical lead exposure: a possible cause of gout.
Authors: B C Campbell, M R Moore, A Goldberg, L A Hernandez, W C Dick
Journal: BMJ (1978)

of prednisolone was reduced to 5 mg daily without relapse.The direct antiglobulin test became negative three months after he started treatment.He has remained well and control of his myasthenia has been unaffected.Thymectomy has not been recommended because of his poor respiratory reserve.
Management of Angioma
Authors: Francesco Ronchese
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In regard to the management of angioma, I disagree with Dr. Kindel's statement inThe Journal, Oct. 15, 1960, page 872, that the "watchful waiting" type of management is currently popular and accepted dogmatically. If it were so, we would have far more statistics to offer concerning the results of such therapy. I cannot see what terrible circumstances will follow if an angioma the size of a half dollar on an infant's buttock is left untreated. It is tragic indeed to see the same angioma located on an infantile vulva treated with radiation or by surgery. I have saved several from such a fate. Bleeding of a small angioma should not cause worry. In the cases in which I witnessed spontaneous involution, the result was cosmetically far superior to any treated ones, with any method. Dr. Kindel's paper is rather dogmatic in stating that radiations are the
Group cognitive and behavioural treatment for hypochondriasis.
Authors: R Stern, M Fernandez
Journal: BMJ (1991)

To assess the feasibility of carrying out group cognitive and behavioural treatment for hypochondriasis in a general hospital setting.Assessment of patients referred for therapy.District general hospital.Six patients aged 35 to 55 (mean 43) years with a mean duration of symptoms of 12 years who fulfilled the Diagnostic and Statistical Manual for Mental Disorders (DSM III-R) criteria for hypochondriasis.Number of visits to their doctors, time spent thinking about illness, and scores on the hospital anxiety and depression scales.The mean number of visits to a doctor fell significantly after treatment (3 before treatment v 0.8 after treatment; p = 0.03) as did the time spent thinking about illness (57.3 v 40.6; p = 0.14). The depression and anxiety scores also fell, although the differences were not significant (depression: 9.5 before v 8.5 after; anxiety: 13 before v 12 after).It is feasible to carry out group cognitive and behavioural treatment in patients with hypochondriasis, and controlled studies are now indicated.
Suspension of hepatitis B vaccinationcondemned
Authors: A. Dorozynski
Journal: BMJ (1998)

The World Health Organisation and French paediatricians have condemned the French government's decision to suspend hepatitis B vaccinations in schools.

Dr Bernard Kouchner, secretary of state for health, made the decision earlier this month as a temporary measure, pending an investigation into the possibility that hepatitis B vaccine could cause multiple sclerosis or other forms of demyelination …
Correction: Left Ventricular Contractility and Blood-Ionized Calcium
Authors: Marcus A. Krupp
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 October 1988Correction: Left Ventricular Contractility and Blood-Ionized CalciumMarcus A. Krupp, MDMarcus A. Krupp, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-7-600_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The transition to SI units for reporting clinical chemistry results has been difficult enough for the reader accustomed to the old method. It becomes more difficult, therefore, to identify errors in reports. The article by Lang and colleagues (1) on the effects of blood-ionized calcium (should be plasma-ionized calcium) contains an error in reporting total calcium. In Table 1, the values for calcium (that is, total calcium) are 7.2, 10.5, and 12.3 mmol/L. If indeed the unit millimoles per litre was meant, then the total calcium levels become 28.8, 42.0, and 49.2 mg/dL, respectively. Surely, the authors...Reference1. LangFellnerNeumannBushinskyBorow RSADK. Left ventricular contractility varies directly with blood ionized calcium. Ann Intern Med. 1988;108:524-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1988Volume 109, Issue 7Page: 600-600KeywordsCalciumClinical chemistry ePublished: 1 December 2008 Issue Published: 1 October 1988 PDF downloadLoading ...
Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.
Authors: L De Franceschi, L Fumagalli, O Olivieri, R Corrocher, C A Lowell, G Berton
Journal: Journal of Clinical Investigation (1997)

Src-family kinases play a central role in regulation of hematopoietic cell functions. We found that mouse erythrocytes express the Src-family kinases Fgr and Hck, as well as Lyn. To directly test whether Fgr and Hck play any role in erythrocyte function, we analyzed red cells isolated from fgr-/-, hck-/-, and fgr-/- hck-/- knock-out mice. Mean corpuscular hemoglobin concentration and median density are increased, while K content is decreased, in fgr-/- hck-/- double-mutant erythrocytes compared with wild-type, fgr-/-, or hck-/- erythrocytes. Na/K pump and Na/K/Cl cotransport were not altered, but K/Cl cotransport activity was significantly and substantially higher (approximately three-fold) in fgr-/- hck-/- double-mutant erythrocytes. This enhanced K/Cl cotransport activity did not depend on cell age. In fact, in response to bleeding, K/Cl cotransport activity increased in parallel with reticulocytosis in wild-type erythrocytes, while abnormal K/Cl cotransport did not change as a consequence of reticulocytosis in fgr-/- hck-/- double-mutant erythrocytes. Okadaic acid, an inhibitor of a phosphatase that has been implicated in activation of the K/Cl cotransporter, inhibited K/Cl cotransport in wild-type and fgr-/- hck-/- double-mutant erythrocytes to a comparable extent. In contrast, staurosporine, an inhibitor of a kinase that has been suggested to negatively regulate this same phosphatase enhanced K/Cl cotransport in wild-type but not in fgr-/- hck-/- double-mutant erythrocytes. On the basis of these findings, we propose that Fgr and Hck are the kinases involved in the negative regulation of the K/Cl cotransporter-activating phosphatase. Abnormality of erythrocyte K/Cl cotransport in fgr-/- hck-/- double-mutant animals represents the first demonstration that Src-family kinases may be involved in regulation of membrane transport.
Israel delayed medical treatment during attack on Gaza aid flotilla, says UN
Authors: J. Zarocostas
Journal: BMJ (2010)

Israeli forces that stormed the humanitarian aid flotilla seeking to break the blockade of Gaza on 31 May committed serious breaches of international and human rights law, including mistreatment of injured people needing medical care, a report by an independent UN factfinding panel has said.

The three member panel, headed by Judge Karl T Hudson-Phillips QC, a retired judge of the International Criminal Court and former attorney general of Trinidad and Tobago, concluded that such behaviour “constituted grave violations of human rights law and international …
Thrombotic Thrombocytopenic Purpura
Authors: James N George
Journal: New England Journal of Medicine (2006)

A 40-year-old obese black woman has had weakness and epigastric pain for several weeks and diarrhea and vomiting for four days. She does not appear acutely ill; the physical examination is normal except for abdominal tenderness. Her hematocrit is 25 percent. The platelet count is 10,000 per cubic millimeter. The peripheral-blood smear shows occasional fragmented and polychromatophilic red cells. The serum creatinine level is 1.1 mg per deciliter (97.2 μmol per liter), bilirubin 2.5 mg per deciliter (42.8 μmol per liter), and lactate dehydrogenase 722 U per liter (normal, <250). How should this case be managed?
Effect of ischaemia on overdrive suppression in isolated, blood-perfused atrial preparations of dogs
Authors: S. CHIBA, T. W. SIMMONS, M. N. LEVY, H. A. ZIESKE
Journal: Cardiovascular Research (1976)

The magnitude of overdrive suppression of the SA nodal pacemaker activity was markedly influenced by its ischaemia which was produced by occlusion of the perfusion tubing close to the sinus node artery in the in-situ and isolated canine sino-atrial node preparations. In all isolated preparations, postdrive suppression was significantly augmented after occlusion of the perfusion system for at least 120 seconds. It is concluded that total ischaemia depresses sino-atrial node function in the atropinized canine heart and that postdrive suppression is a good index of such impaired function.
Value of booster immunisation with influenza vaccine in patients undergoing haemodialysis.
Authors: D J Versluis, W E Beyer, N Masurel, W Weimar, P Kramer, P P Diderich
Journal: BMJ (1987)

Necessite de doses augmentees parce que les reponses en anticorps sont diminuees chez les malades sous hemodialyses
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
Authors: Ernst Holler, Gerhard Rogler, Hans Herfarth, Julia Brenmoehl, Peter Johannes Wild, Joachim Hahn, Günther Eissner, Jürgen Schölmerich, Reinhard Andreesen
Journal: Blood (2004)
Experimental evaluation of coronary collateral development
Authors: E Unger
Journal: Cardiovascular Research (2001)

During the last decade, there has been great interest in the potential use of biologic agents and mechanical techniques to enhance myocardial collateral development. Available experimental methods to detect the effects of interventions designed to improve collateral function include assessment of vascular cell proliferation, quantification of vessel number and size, appraisal of myocardial perfusion, and evaluation of myocardial function. The purpose of this review is to discuss the various experimental approaches for the evaluation of coronary collateral development, highlighting the relative strengths and limitations of the commonly used animal models and methods of assessment.
Treatment of hypertension with ascorbic acid
Authors: StephenJ Duffy, Noyan Gokce, Monika Holbrook, Annong Huang, Balz Frei, John F Keaney, Joseph A Vita
Journal: The Lancet (1999)

In a randomised, double-blind, placebo-controlled study we showed that treatment of hypertensive patients with ascorbic acid lowers blood pressure. Further studies of ascorbic acid to treat hypertension, with clinical endpoints, are warranted.
Women who have had surgery for obesity have raised risk of preterm babies
Authors: J. Wise
Journal: BMJ (2013)

Women who have had bariatric surgery are at an increased risk of giving birth to a preterm or small baby, a Swedish study has found.1

Researchers from the Karolinska Institute in Stockholm carried out a population based cohort study to examine the association between bariatric surgery and perinatal outcomes. They compared 2562 births after bariatric surgery with 12 468 control births between 1992 and …
Development of Diabetic Complications despite the Absence of Growth Hormone in a Patient with Post-Pancreatectomy Diabetes
Authors: David Radin, Zachary T. Bloomgarden, Stephen S. Feman, Thomas Q. Davis
Journal: New England Journal of Medicine (1984)

IN 1953 Poulsen described a patient with diabetes mellitus in whom retinopathy was ameliorated after postpartum pituitary infarction.1 He pointed out the possible analogy of the events in his patient to the observation of Houssay that experimental diabetes in animals was modified by hypophysectomy.2 Poulsen cautioned against extrapolating his observations to clinical areas.1 Nevertheless, the hypothesis was advanced that some pituitary factor, possibly growth hormone, might be implicated in the pathogenesis of diabetic retinopathy.3 Over the next two decades, many hundreds of diabetic patients underwent some form of therapy designed to ablate or reduce pituitary function.3 Although a beneficial effect . . .
Surgeons cleared of serious professional misconduct by GMC
Authors: O. Dyer
Journal: BMJ (2002)

Two surgeons who argued over their operation notes after destroying a patient's liver in an unnecessary operation have been cleared of serious professional misconduct by the General Medical Council.

Locum consultant surgeon Adel Zaki Demian, 59, and Vijay Vardhini, 37, were found guilty of several charges, but the council's professional conduct committee chose not to sanction them after hearing expert testimony that the patient's condition was unusual enough to confuse any doctor.

Mother of three Elif Aksu, 34, appeared at the accident and emergency ward of the Homerton Hospital, east London, on 1 December 1997, complaining of abdominal …
Denis Edward Fletcher
Authors: Anne Hobbs, Charles Fletcher
Journal: BMJ (2005)

​FormerFormer consultant radiologist Barrow-in-Furness (b Tadcaster 1923; q Leeds 1945; MD, FFR), d 30 April 2005.




Figure 1




After three years in the Royal Air Force Denis trained in radiology at Manchester University and then took up the post of senior consultant radiologist for the Furness hospitals group, based at Barrow. He held this post for almost 30 years, during which time he established and ran the school of radiography and took his MD based on a study of asbestos related disorders. Denis had many external interests, including family history and collecting coins and local fossils. He also made a considerable amount of carved oak furniture and meticulous railway engines and layouts. He leaves a wife, Elizabeth; two children; and two grandchildren.