tbuckley/cabot-search huggingface dataset:
Denial of Handgun Purchase to Violent Misdemeanants
Authors: Paul H. Blackman
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Crime victims are given right to object to disclosure of their medical records to courts
Authors: Clare Dyer
Journal: BMJ (2006)

A Crown Court judge acted unlawfully in ordering an NHS trust to hand over the psychiatric records of a 14 year old girl—without giving her a chance to object—to the man who was accused of sexually abusing her. This was a ruling by two senior judges at the High Court in London last week.

The ruling has widespread implications throughout the criminal justice system, particularly in rape cases. Judges often order doctors to disclose a crime victim's psychiatric records to the defendant's lawyers, who want to use them to undermine the plaintiff's credibility as a …
RANK ligand and the regulation of skeletal remodeling
Authors: Norman H. Bell
Journal: Journal of Clinical Investigation (2003)

ConclusionSo where do we stand today?We now appreciate that CX3CR1 and presumably fractalkine are important players in atherogenesis, and that CX3CR1 contains polymorphisms that modulate its adhesive and signaling functions and are associated with reduced risk of atherosclerotic cardiovascular disease.But to truly understand the mechanism of CX3CR1 and other genes in a highly complex and chronic disease process such as atherosclerosis, new practical intermediate markers are required in both experimental models and clinical studies.1.
Patient Age and Comorbidity Are Major Determinants of Adjuvant Chemotherapy Use for Stage III Colon Cancer in Routine Clinical Practice
Authors: Sumitra Ananda, Kathryn M. Field, Suzanne Kosmider, Daniel Compston, Jayesh Desai, Lionel C. Lim, Frances S. Barnett, Ian T. Jones, Iain Skinner, Peter Gibbs
Journal: Journal of Clinical Oncology (2008)
Leukaemia and neoplastic processes treated with Langat and Kyasanur Forest disease viruses: a clinical and laboratory study of 28 patients.
Authors: H. E. Webb, G. Wetherley-Mein, C. E. Smith, D. McMahon
Journal: BMJ (1966)

Pain in Neck and Arm MEDICALJOURNALTemporary relief of pain at the time of treatment was recorded in 92% of the patients receiving traction and 86% of those who were positioned without traction.The rate of improvement was approximately the same in the five treatment groups, as judged by clinical assessment two weeks and four weeks after the beginning of treatment and by follow- up questionary at six weeks and six months.The improvement at four weeks was influenced by age, the initial severity of symptoms, the number of previous attacks, the duration of previous attacks, and whether the patient was getting better or worse when first seen.We are deeply indebted to all the patients, doctors, physiotherapists, secretaries, and administrative staff who helped with this trial.Dr. D. J. Newell and his staff did invaluable work in analysing the statistics.Dr. P. J. R. Nichols was responsible for organizing and co-ordinating the returns from each centre.
Effectiveness of seasonal trivalent inactivated influenza vaccine in preventing influenza hospitalisations and primary care visits in Auckland, New Zealand, in 2013
Authors: N Turner, N Pierse, A Bissielo, Q S Huang, S Radke, M G Baker, M  A Widdowson, H Kelly, Collective on behalf of the SHIVERS investigation team
Journal: Eurosurveillance (2014)

Binary file ES_Abstracts_Final_ECDC.txt matches
Successful treatment of T‐γ lymphoproliferative disease with human‐recombinant granulocyte colony stimulating factor
Authors: David F. Lang, C. S. Rosenfeld, H. S. Diamond, R. K. Shadduck, Z. R. Zeigler
Journal: American Journal of Hematology (1992)

Abstract A trial of recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) was attempted in a male with agranulocytosis, infection, and T‐gamma lymphoproliferative disease (T‐γ‐LPD). During five days of rhG‐CSF (960 μg/day), the absolute neutrophil count (ANC) increased from 0.0 to 4.5 K/μI. There were no changes in eosinophil or lymphocyte counts. In addition, there was no toxicity. Bone marrow cytotoxic/suppressor cells (CD57+/CD8+) were elevated (21.9%) before and decreased to 10.6% (normal &lt; 12%) following rhG‐CSF. By contrast, there was no change in activated T cells (CD3+DR+) or T cell gene rearrangements. These findings suggest rhG‐CSF can improve granulopoiesis in T‐γ‐LPD, possibly by altering T‐cell mediated marrow suppression. © 1992 Wiley‐Liss, Inc.
Effect of long term iloprost (prostacyclin‐stable analogue) infusion in primary and secondary severe pulmonary hypertension
Authors: M. Lazaro, M.A. Gomez Sanchez, P. Escribano, J.F. Delgado, R. Tello de Meneses, M. Pombo, M. Aranzana, A. Albarran, J. Tascon, C. Saenz de la Calzada
Journal: European Journal of Heart Failure (2000)
TREATMENT OF FRACTURE OF THE INFERIOR MAXILLA, WITH DESCRIPTION OF A SPLINT.
Authors: GEORGE MORRIS DORRANCE
Journal: JAMA (1906)

Fractures of the lower jaw are divided into fractures of the body, the ramus, the angle and the condyloid and coronoid processes. The most frequent variety is fracture of the body at the mental foramen; frequently the fracture is double, being two of the same variety or a combination of two different varieties. Numerous mechanical devices and operative procedures have been advanced for the treatment of these fractures, but, if one may judge from the numerous articles which appear each year, none give entire satisfaction. No one apparatus or operation will be satisfactory for all varieties of fracture of the inferior maxilla. The treatment of these fractures with the use of a chin cup and a Barton's bandage is antiquated and entirely unreliable, as well as being very uncomfortable. To be systematic, we will take up the different varieties in turn. <h3>FRACTURE OF THE BODY WITHIN THE ALIGNMENT OF THE</h3>
Beware of Whites Bearing Gifts
Authors: GERALD MELCHIODE, SAM C. GOULD, PAUL JAY FINK
Journal: American Journal of Psychiatry (1970)

The authors describe their study of four black students who participated in a special 13th year of schooling in predominantly white private schools. They found that the students' difficulties in the program resulted in a loss of self-esteem and the precipitation of an identity crisis to which they were particularly vulnerable because of inadequate preparation and the lack of peer support. The authors present a set of recommendations for prevention of these difficulties in other programs.
Adipose tissue explants and MDCK cells reciprocally regulate their morphogenesis in coculture
Authors: Kazuma Udo, Shigehisa Aoki, Kazuyoshi Uchihashi, Maki Kawasaki, Aki Matsunobu, Yuji Tokuda, Akifumi Ootani, Shuji Toda, Jiro Uozumi
Journal: Kidney International (2010)
Localization of Na <sup>+</sup> Channel Isoforms at the Atrioventricular Junction and Atrioventricular Node in the Rat
Authors: Shin Yoo, Halina Dobrzynski, Vadim V. Fedorov, Shang-Zhong Xu, Tomoko T. Yamanushi, Sandra A. Jones, Mitsuru Yamamoto, Vladmir P. Nikolski, Igor R. Efimov, Mark R. Boyett
Journal: Circulation (2006)

Background— The electrical activity of the atrioventricular node (AVN) is functionally heterogeneous, but how this relates to distinct cell types and the 3-dimensional structure of the AVN is unknown. To address this, we have studied the expression of Na v 1.5 and other Na + channel isoforms in the AVN. Methods and Results— The rat AVN was identified by Masson’s trichrome staining together with immunolabeling of marker proteins: connexin40, connexin43, desmoplakin, atrial natriuretic peptide, and hyperpolarization-activated and cyclic nucleotide–gated channel 4. Na + channel expression was investigated with immunohistochemistry with isoform-specific Na + channel antibodies. Na v 1.1 was distributed in a similar manner to Na v 1.5. Na v 1.2 was not detected. Na v 1.3 labeling was present in nerve fibers and cell bodies (but not myocytes) and was abundant in the penetrating atrioventricular (AV) bundle and the common bundle but was much less abundant in other regions. Na v 1.5 labeling was abundant in the atrial and ventricular myocardium and the left bundle branch. Na v 1.5 labeling was absent in the open node, penetrating AV bundle, AV ring bundle, and common bundle but present at a reduced level in the inferior nodal extension and transitional zone. Na v 1.6 was not detected. Conclusions— Our findings provide molecular evidence of multiple electrophysiological cell types at the AV junction. Impaired AV conduction as a result of mutations in or loss of Na v 1.5 must be the result of impaired conduction in the AVN inputs (inferior nodal extension and transitional zone) or output (bundle branches) rather than the AVN itself (open node and penetrating AV bundle).
Phase II Study of Bendamustine in Relapsed Chemotherapy Sensitive or Resistant Small-Cell Lung Cancer
Authors: Philip E. Lammers, Yu Shyr, Chung-I Li, Anne Smith Hutchison, Alan Sandler, David Paul Carbone, David H. Johnson, Vicki Leigh Keedy, Leora Horn
Journal: Journal of Thoracic Oncology (2014)
Abstract 1764: DOTA-conjugated antibodies for scintigraphic evaluation of new anti cancer treatments
Authors: Olivier Raguin, Mathieu Moreau, Bertrand Collin, François Brunotte, Xavier Tizon, Olivier Duchamp, Frederic Boschetti, Franck Denat
Journal: Cancer Research (2011)

Abstract Introduction: The treatment of cancer is being revolutionized by the development of targeted therapeutic biologics. Translational pharmaco-imaging represents a key step in the evaluation of these new targeted anti cancer therapies. In this respect, we have implemented and validated an antibody radiolabeling process for scintigraphic SPECT imaging. Methods: A new macrocyclic reagent (DOTAGA, bearing an anhydride function able to react with primary amines) was used for DOTA conjugation of Trastuzumab®. DOTA Trastuzumab was synthesized by directly reacting DOTAGA with Trastuzumab®. The number of DOTA per antibody was determined using mass spectrometry. The DOTA-conjugated antibodies were metallated with Indium-111. The functionality of DOTA Trastuzumab analogs was evaluated by in vitro saturation assays using two human breast cancer cell lines (SK BR 3 and HCC1954). Results: Two DOTA- Trastuzumab analogs were synthesized. The first analog was bearing one DOTA per antibody while the second was bearing 4 DOTA per antibody. The labeling yield reached 90% for both conjugates and high specific activities were obtained (400 MBq/mg). The affinity of the DOTA Trastuzumab analogs, determined on Her2 expressing SK BR 3 and HCC1954 cell lines, was 1 nM and was similar to that of Trastuzumab®. SPECT imaging experiments in tumor bearing rodents are in progress for in vivo validation of the two analogs. Conclusion: Together, these results demonstrate the efficiency of our new DOTA-synthesis and conjugation processes for biologics radiolabeling to assess biodistribution, anti-cancer efficacy and related toxicity of anti-cancer drugs by in vivo non invasive imaging. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1764. doi:10.1158/1538-7445.AM2011-1764
Epidermal Homeostasis: The Role of the Growth Hormone and Insulin-Like Growth Factor Systems
Authors: Stephanie R. Edmondson, Susan P. Thumiger, George A. Werther, Christopher J. Wraight
Journal: Endocrine Reviews (2003)

Abstract GH and IGF-I and -II were first identified by their endocrine activity. Specifically, IGF-I was found to mediate the linear growth-promoting actions of GH. It is now evident that these two growth factor systems also exert widespread activity throughout the body and that their actions are not always interconnected. The literature highlights the importance of the GH and IGF systems in normal skin homeostasis, including dermal/epidermal cross-talk. GH activity, sometimes mediated via IGF-I, is primarily evident in the dermis, particularly affecting collagen synthesis. In contrast, IGF action is an important feature of the dermal and epidermal compartments, predominantly enhancing cell proliferation, survival, and migration. The locally expressed IGF binding proteins play significant and complex roles, primarily via modulation of IGF actions. Disturbances in GH and IGF signaling pathways are implicated in the pathophysiology of several skin perturbations, particularly those exhibiting epidermal hyperplasia (e.g., psoriasis, carcinomas). Additionally, many studies emphasize the potential use of both growth factors in the treatment of skin wounds; for example, burn patients. This overview concerns the role and mechanisms of action of the GH and IGF systems in skin and maintenance of epidermal integrity in both health and disease.
ZNF423 Is Critically Required for Retinoic Acid-Induced Differentiation and Is a Marker of Neuroblastoma Outcome
Authors: Sidong Huang, Jamila Laoukili, Mirjam T. Epping, Jan Koster, Michael Hölzel, Bart A. Westerman, Wouter Nijkamp, Akiko Hata, Shahab Asgharzadeh, Robert C. Seeger, Rogier Versteeg, Roderick L. Beijersbergen, René Bernards
Journal: Cancer Cell (2009)
Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment
Authors: Yukari Muguruma, Takashi Yahata, Hiroko Miyatake, Tadayuki Sato, Tomoko Uno, Jobu Itoh, Shunichi Kato, Mamoru Ito, Tomomitsu Hotta, Kiyoshi Ando
Journal: Blood (2005)
Bulimia vs Bulimic Behaviors on a College Campus
Authors: David E. Schotte
Journal: JAMA (1987)

A self-report survey of bulimic behaviors was conducted with 1965 students who were selected to provide a cross section of a large, eastern university. Follow-up interviews of a subsample of respondents were conducted to validate the survey. After correcting for false-positive responses, only 1.3% of the female and 0.1% of the male respondents met diagnostic criteria for bulimia according to either the third edition or the proposed revision of the Diagnostic and Statistical Manual of Mental Disorders. In addition, an inflection point was found in the rates of binge eating, self-induced vomiting, and their combination at a frequency of about twice per month.
Prognosis of Intermittent Claudication
Authors: R. L. Richards
Journal: BMJ (1957)

The results justify the conclusion that, no matter how serious the rheumatic heart condition may be, pregnancy should not be terminated at any stage, nor abdominal delivery resorted to. SummaryThe case histories of 289 pregnancies complicated by rheumatic heart disease are analysed.One mother died before the end of the puerperium (0.3%).Thirteen viable infants did not survive the neonatal period (4.6%).Mitral commissurotomy was per- formed on three occasions (1 %).No caesarean section or induction of labour was performed for heart disease.No therapeutic abortion was performed.We are grateful to our colleagues at the National Maternity Hospital for their co-operation in the management of these patients.
Sural nerve oxygen tension in diabetes.
Authors: P G Newrick, A J Wilson, J Jakubowski, A J Boulton, J D Ward
Journal: BMJ (1986)

Peripheral nerve oxygen tensions were assessed in vivo by using microelectrodes to measure endoneurial oxygen tension in exposed sural nerve. In 11 diabetic patients with chronic sensorimotor neuropathy the mean endoneurial oxygen tension was 39.7 (SD 10.2) mm Hg. In all but one patient compared with none of four non-neuropathic subjects the mean nerve oxygen tensions were below dorsal foot vein values. This unphysiological state may have a role in the aetiology of diabetic neuropathy.
Re: Martin Spahn, Steven Joniau, Paolo Gontero, et al. Outcome Predictors of Radical Prostatectomy in Patients With Prostate-Specific Antigen Greater Than 20 ng/ml: A European Multi-Institutional Study of 712 Patients. Eur Urol 2010;58:1–7
Authors: Endre Zoltan Neulander, Zev Wejsman
Journal: European Urology (2010)
Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice
Authors: Valeska Heib, Marc Becker, Tobias Warger, Gerd Rechtsteiner, Christine Tertilt, Matthias Klein, Tobias Bopp, Christian Taube, Hansjörg Schild, Edgar Schmitt, Michael Stassen
Journal: Blood (2007)
ABC of computing. Computers in the laboratory.
Authors: J Drury
Journal: BMJ (1983)

PatientThe objective of the clinical laboratory is to provide meaningful information for the management of Ana,yi patients through the scientific analysis of samples.With the increase in both the number and range of investigations required, the old manual techniques and data handling systems have become unable to cope, and a disproportionate amount of time is devoted to calculating results and performing -38 simple clerical duties.The introduction of the computer into the pathology laboratory has solved many of these problems and shown the successful application of computer technology to medical practice.The processing ofa sample, which includes receipt of the sample, analysis, calculation of the result, quality assurance, storage, and manipulation and transmission of data, presents two principal challenges: the management of a large volume of data and the control of complex analytical equipment.The data handled in a laboratory are very varied.As well as the actual request for a test, the information associated with one request might comprise the details of the patient-including name, hospital number, consultant, ward-and also information that helps the pathologist judge the meaning of the results, such as age, sex, time of day and clinical details.A day's work may generate hundreds of records and millions of pieces of information, all of which must be stored compactly yet be capable of rapid retrieval.This storage problem is solved by using random access files held on magnetic discs which allow individual items in the file to be altered without disturbing others.There are several techniques for data management, and each involves a whole computer package containing several programs accessing a variety offiles.One type oflaboratory system, for example, uses three main files: the clinical file, the work file, and the report file.The clinicalfile contains two types of record.The patient identity record consists of the hospital record number, surname, first name, age, sex, consultant, etc.The second record-the result record-lists the type of specimen, the test requested, date, results obtained, and added free text comments.An identifier key precedes each record to allow direct access to data.This key is made up of the hospital record number plus an integer; if
RELATIONSHIP BETWEEN VASCULAR FUNCTION, VENTRICULAR-VASCULAR COUPLING AND PERIPHERAL PRESSURE PULSATILITY IN HYPERTROPHIC CARDIOMYOPATHY
Authors: Patrick J. Warner, Heather Nickerson, Eshan Patvardhan, Martin Maron, Craig Napolitano, Jenny Ruan, Kevin Heffernan, Richard Karas, Jeffrey Kuvin
Journal: Journal of the American College of Cardiology (2011)
Prevention of critical telomere shortening by oestradiol in human normal hepatic cultured cells and carbon tetrachloride induced rat liver fibrosis
Authors: R Sato
Journal: Gut (2004)

<b>Background and aim:</b> Significant telomere shortening of hepatocytes is associated with replicative senescence and a non-dividing state in chronic liver disease, resulting in end stage liver failure and/or development of hepatocellular carcinoma. To prevent critical telomere shortening in hepatocytes, we have focused on oestrogen dependent transactivation of the human telomerase reverse transcriptase (<i>hTERT</i>) gene as a form of telomerase therapy in chronic liver disease. <b>Methods:</b> We examined expression of <i>hTERT</i> mRNA and its protein, and telomerase activity (TA) in three human normal hepatic cell lines (Hc-cells, h-Nheps, and WRL-68) before and after treatment with 17β-oestradiol. The effects of exogenous oestradiol administration were examined in a carbon tetrachloride (CCl<sub>4</sub>) induced model of liver fibrosis in rats. <b>Results:</b> Expression of <i>hTERT</i> mRNA and its protein was upregulated by oestradiol treatment. Telomere length decreased in Hc-cells and h-Nheps with accumulated passages whereas with long term oestradiol exposure it was greater than without oestradiol. The incidence of β-galactosidase positive cells, indicating a state of senescence, decreased significantly in oestradiol treated cells in comparison with non-treated cells (p&lt;0.05). TA in both male and female rats with CCl<sub>4</sub> induced liver fibrosis was significantly higher with oestradiol administration than without (p&lt;0.05). Long term oestradiol administration markedly rescued the hepatic telomere from extensive shortening in both male and female rats. <b>Conclusion:</b> These results suggest that oestradiol acts as a positive modulator of the <i>hTERT</i> gene in the liver. Oestrogen dependent transactivation of the <i>hTERT</i> gene is a new strategy for slowing the progression of chronic liver disease.
Late Calls and Early Calls
Authors: J. C. Gilmour
Journal: BMJ (1964)

BDffMponsibilities and carry their burdens without themselves breaking under the strain.Social workers everywhere are trained to respect their clients' integrity and to en- courage them to make their own decisions with a view to helping them retain or recover their self-respect and independence as far as may be possible.Only as a last resort will a social worker seek to solve the problem by removing it-for example, by arranging insti- tutional care.Moreover, the importance they attach to the uniqueness of the individual, whoever he may be and whatever his circumstances, which is a basic principle of social casework, helps to counteract the tendency to standardization which is a recognized risk arising from the size and complexity of the social services.Admittedly, the developments just described do not and cannot go all the way to overcoming the tendency, to which all of us are liable in greater or lesser degree, to accept what is given and rely on others to see us through our difficulties, and any attempt to alleviate distress by collective provisions involves the risk of encouraging this, but I think it right, especially in view of the quota- tions cited by Pertinax, to draw attention to the fact that the most recent developments in the social services are directed towards giving individuals and families (to quote the Child- ren and Young Persons Act, 1963) "professional advice, guidance and assistance," which, it is hoped, will encourage and enable them to cope with their difficulties without forfeiting their independence and self-respect.