tbuckley/cabot-search huggingface dataset:
Effect of Escherichia coli on Fluid Transport across Canine Small Bowel MECHANISM AND TIME-COURSE WITH ENTEROTOXIN AND WHOLE BACTERIAL CELLS
Authors: R. L. Guerrant, U. Ganguly, A. G. T. Casper, E. J. Moore, N. F. Pierce, C. C. J. Carpenter
Journal: Journal of Clinical Investigation (1973)

An Escherichia coli strain isolated from a patient with severe cholera-like diarrhea elaborates a partly heat-labile enterotoxin shown to cause prompt adenyl cyclase stimulation and isotonic fluid secretion by canine jejunum. Both responses disappear upon removal of the enterotoxin. The duration of action of a submaximal dose of this E. coli enterotoxin was brief, despite sustained exposure to the jejunum, suggesting inactivation of the enterotoxin by its interaction with the mucosa. Inoculation of whole bacterial cultures of this E. coli strain into canine duodenum was followed by bacterial survival and induction of net secretion after 4-7 h. The onset of fluid production was associated with increasing gut mucosal adenyl cyclase activity. Washed bacterial cells could also produce fluid secretion. In vivo multiplication of this enterotoxin-producing E. coli was demonstrated 6-12 h after intraduodenal inoculation of approximately 10(6) organisms. This was associated with fluid secretion. Intestinal fluid production occurred without microscopic pathology in the mucosa.
Exposure-effect relationship of platinum salt allergy in a catalyst production plant: Conclusions from a 5-year prospective cohort study
Authors: Rolf Merget, Rupprecht Kulzer, Alexandra Dierkes-Globisch, Rolf Breitstadt, Anja Gebler, Annegret Kniffka, Sabine Artelt, Hans-Peter Koenig, Friedrich Alt, Reinhard Vormberg, Xaver Baur, Gerhard Schultze-Werninghaus
Journal: Journal of Allergy and Clinical Immunology (2000)
Progressive Multifocal Leukoencephalopathy in a Male Homosexual with T-Cell Immune Deficiency
Authors: James R. Miller, Robert E. Barrett, Carolyn B. Britton, Michael L. Tapper, Gerald S. Bahr, Peter J. Bruno, Merlin D. Marquardt, Arthur P. Hays, James G. McMurtry, Jack B. Weissman, Michael S. Bruno
Journal: New England Journal of Medicine (1982)

AN acquired immune deficiency in male homosexuals that is manifested by infection with one or more opportunistic microorganisms has recently been recognized. These agents have included cytomegalovirus, Toxoplasma gondii, Pneumocystis carinii, Candida albicans, Mycobacterium avium–intracellulare, and Cryptococcus neoformans.1 2 3 4 A prolonged clinical course with an otherwise self-limited infection, such as herpes simplex infection, has also been described,3 and a remarkable incidence of Kaposi's sarcoma has been reported.1 2 3 4 5 In this milieu, the occurrence of progressive multifocal leukoencephalopathy (PML) might be expected. We present the case of a male homosexual with a T-cell immune deficiency, in whom PML . . .
Phylogenetic analysis of a retrotransposon with implications for strong evolutionary constraints on reverse transcriptase
Authors: B. F. McAllister, J. H. Werren
Journal: Molecular Biology and Evolution (1997)

This study examines the evolutionary dynamics of a retrotransposon in a group of parasitoid wasps. A region containing the reverse transcriptase (RT) domain was sequenced for 43 elements from the genomes of nine different wasp species. Phylogenetic analysis of the elements revealed concordance with taxonomic classification of the host species, and the pattern was consistent with that expected for vertical transmission of a multicopy element during differentiation of the species. Twenty-three of the 43 elements had comparable intact open reading frames in the amplified region, and these were used in an analysis of evolutionary constraint on the amino acid sequence. As previously documented for retroelements, closely related elements exhibited nearly equal substitution rates at nonsynonymous and synonymous sites, but relative nonsynonymous substitution rates decreased as increasingly divergent elements were compared. A statistical test indicated that the decrease was not due to saturation of weakly selected sites. The pattern is most likely caused by a "pseudogene effect." Individual elements are not subject to purifying selection, and therefore, synonymous and nonsynonymous substitutions accumulate at equal rates. Comparisons among closely related elements are influenced strongly by this pseudogene evolution, whereas comparisons among distantly related elements reveal selection on the actively replicating lineages connecting the elements. These distant comparisons more accurately reflect the constraints on the amino acid sequence, and the comparisons among elements in this study indicated strong constraints on RT.
The Confidence in Diabetes Self-Care Scale
Authors: Nicole C.W. van der Ven, Katie Weinger, Joyce Yi, Frans Pouwer, Herman Adèr, Henk M. van der Ploeg, Frank J. Snoek
Journal: Diabetes Care (2003)

OBJECTIVE—To examine psychometric properties of the Confidence in Diabetes Self-Care (CIDS) scale, a newly developed instrument assessing diabetes-specific self-efficacy in Dutch and U.S. patients with type 1 diabetes. RESEARCH DESIGN AND METHODS—Reliability and validity of the CIDS scale were evaluated in Dutch (n = 151) and U.S. (n = 190) outpatients with type 1 diabetes. In addition to the CIDS scale, assessment included HbA1c, emotional distress, fear of hypoglycemia, self-esteem, anxiety, depression, and self-care behavior. The Dutch sample completed additional measures on perceived burden and importance of self-care. Test-retest reliability was established in a second Dutch sample (n = 62). RESULTS—Internal consistency (Cronbach’s α = 0.86 for Dutch patients and 0.90 U.S. patients) and test-retest reliability (Spearman’s r = 0.85, P &amp;lt; 0.0001) of the CIDS scale were high. Exploratory factor analysis showed one strong general factor. Spearman’s correlations between the CIDS scale and other measures were moderate and in the expected directions, and high HbA1c levels were associated with low CIDS scores in the U.S. sample only. Low CIDS scores were positively associated with self-care but not with glycemic control in the original samples. CIDS scores in the U.S. and Dutch samples did not show any statistically significant differences. U.S. men had higher CIDS scores than U.S. women. CONCLUSIONS—The CIDS scale is a reliable and valid measure of diabetes-specific self-efficacy for use in patients with type 1 diabetes. High psychometric similarity allows for cross-cultural comparisons.
Endocardial mapping of ventricular tachycardia in the intact human ventricle. III. Evidence of multiuse reentry with spontaneous and induced block in portions of reentrant path complex
Authors: Eugene Downar, Junichi Saito, J. Colin Doig, Thomas C.K. Chen, Elias Sevaptsidis, Stephane Masse, Shane Kimber, Lynda Mickleborough, Louise Harris
Journal: Journal of the American College of Cardiology (1995)
ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia
Authors: Januario E. Castro, Carlos E. Prada, Olivier Loria, Adeela Kamal, Liguang Chen, Francis J. Burrows, Thomas J. Kipps
Journal: Blood (2005)
Effectiveness of Systems Training for Emotional Predictability and Problem Solving (STEPPS) for Borderline Personality Problems in a ‘Real-World’ Sample: Moderation by Diagnosis or Severity?
Authors: Elisabeth H. Bos, E. Bas van Wel, Martin T. Appelo, Marc J.P.M. Verbraak
Journal: Psychotherapy and Psychosomatics (2011)

&lt;i&gt;Background:&lt;/i&gt; Systems Training for Emotional Predictability and Problem Solving (STEPPS) is a group treatment for borderline personality disorder (BPD). Two prior randomized controlled trials (RCTs) have shown the efficacy of this training. In both RCTs, patients with borderline features who did not meet the DSM-IV criteria for BPD were excluded, which were many. We investigated the effectiveness of STEPPS in a sample representative of routine clinical practice and examined whether DSM-IV diagnosis and/or baseline severity were related to differential effectiveness. &lt;i&gt;Methods:&lt;/i&gt; Patients whom their practicing clinician diagnosed with BPD were randomized to STEPPS plus adjunctive individual therapy (STEPPS, n = 84) or to treatment as usual (TAU, n = 84). &lt;i&gt;Results:&lt;/i&gt; STEPPS recipients showed more improvement on measures of general and BPD-specific psychopathology as well as quality of life than TAU recipients, both at the end of treatment and at a 6-month follow-up. Presence of DSM-IV-diagnosed BPD was not related to differential treatment effectiveness, but dimensional measures of symptom severity were; STEPPS was superior to TAU particularly in patients with higher baseline severity scores. &lt;i&gt;Conclusions:&lt;/i&gt; The findings show the effectiveness of STEPPS in a ‘real-world’ sample, and underscore the importance of dimensional versus categorical measures of personality disturbance.
Abstract 5383: The plasmonic photothermal therapy efficacy of Au NRs <i>in vivo</i> using a SCCHN xenograft mouse model
Authors: Xianghong Peng, Megan A. Mackey, Adegboyega Oyelere, Jun Zhang, Georgia Chen, Shuming Nie, Mostafa A El-Sayed, Dong M Shin
Journal: Cancer Research (2014)

Abstract The plasmonic photothermal therapy (PPTT) is promising for the treatment of cancer because it overcomes the challenges in conventional treatments by avoiding drug resistance, surgery infections, and minimizing healthy cell destruction. It is well suited for the treatment of the squamous cell carcinoma of the head and neck (SCCHN) as this type of cancer is readily accessible to NIR light. We have synthesized the Au nanorods (NRs) with different sizes (25nm and 40nm) and modified the particle surface with PEG stabilizer, and conjugated Au NRs with SCCHN-targeted HNSCP peptides. The new Au NRs -assisted PPTT was tested in a SCCHN xenografted tumor model. The SCCHN xenograft tumors were inoculated by injection of 1x106 Tu212 cells subcutaneously into the right flank of nude mice and allowed to grow to approximately 100 mm3. Fifty nude mice were divided into ten groups (n=5) in a way to minimize weight and tumor size differences among the groups: control group treated with PBS (A), laser treatment (diode laser, 808 nm, 1-2 W/cm2, 1cm diameter, 2 min) (B), non-targeted AuNRs ( 25nm size) with (C)or without laser treatment(D), HNSCP-Au NRs(25 nm size) with (E) or without laser treatment( F), non-targeted Au NRs (40 nm size) with (G) or without laser treatment (H), HNSCP-Au NRs(40 nm size) with (I) or without laser treatment (J). Au NRs (25 μL) at concentration of, 25 nM in PBS buffer were injected into mice via intratumoral injection. Our results showed that the Au NRs with laser treatment could significantly inhibit the tumor growth in vivo compared with that of control and laser treatment only groups (without Au NRs). In addition, the tumor targeted Au NRs didn't show enhanced antitumor efficacy compared with the non-tumor targeted Au NRs. The mice showed complete response to the PPTT didn't have tumor relapse after 15 weeks of the treatment. There are no remarkable toxicities observed. (This research was supported by the National Cancer Institute award 5U01CA151802 ) Citation Format: Xianghong Peng, Megan A. Mackey, Adegboyega Oyelere, Jun Zhang, Georgia Chen, Shuming Nie, Mostafa A El-Sayed, Dong M Shin. The plasmonic photothermal therapy efficacy of Au NRs in vivo using a SCCHN xenograft mouse model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5383. doi:10.1158/1538-7445.AM2014-5383
Asthma control in Europe: A real-world evaluation based on an international population-based study
Authors: Lucia Cazzoletti, Alessandro Marcon, Christer Janson, Angelo Corsico, Deborah Jarvis, Isabelle Pin, Simone Accordini, Enrique Almar, Massimiliano Bugiani, Adriana Carolei, Isa Cerveri, Enric Duran-Tauleria, David Gislason, Amund Gulsvik, Rain Jõgi, Alessandra Marinoni, Jesús Martínez-Moratalla, Paul Vermeire, Roberto de Marco
Journal: Journal of Allergy and Clinical Immunology (2007)
STUDIES ON THE ETIOLOGY OF HEARTWATER
Authors: E. V. Cowdry
Journal: The Journal of Experimental Medicine (1925)

The evidence offered in the first of these studies indicative of a causative relationship between Rickettsia ruminantium and heartwater is supplemented by the following observations concerning the ticks which carry the disease. When larvae, which had taken no food since hatching, were allowed to feed upon cases of heartwater, they acquired Rickettsioe which appeared to be identical with those in the tissues of animals suffering from heartwater, whereas control larvae hatched from eggs deposited by the same female and fed on normal animals remained free of Rickettsioe. After larvae presumably infective had moulted, the resultant nymphae containing Rickettsioe in their alimentary tracts, when fed upon susceptible animals produced in them typical attacks of heartwater, which the control nymphae, devoid of Rickettsioe, failed to do. The tissues of animals thus infected were found upon histological examination to contain typical Rickettsioelig;.
Which animal model for understanding human navigation in a three-dimensional world?
Authors: Guy A. Orban
Journal: Behavioral and Brain Sciences (2013)

Abstract Single-cell studies of monkey posterior parietal cortex (PPC) have revealed the extensive neuronal representations of three-dimensional subject motion and three-dimensional layout of the environment. I propose that navigational planning integrates this PPC information, including gravity signals, with horizontal-plane based information provided by the hippocampal formation, modified in primates by expansion of the ventral stream.
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury
Authors: Nam-On Ku, Roy M. Soetikno, Bishr M. Omary
Journal: Hepatology (2003)

Hepatocytes express keratins 8 and 18 (K8/18) as their only cytoskeletal intermediate filament (IF) proteins, and K8/18 mutations predispose their carriers to liver cirrhosis. Transgenic mice that overexpress mutant human K18 (Arg89→Cys [R89C]) develop mild chronic hepatitis, hepatocyte fragility, keratin filament disruption, and increased susceptibility to drug–induced liver injury. K18 is a major caspase substrate during apoptosis, and K8– or K18–null mice are significantly predisposed to Fas– and possibly tumor necrosis factor (TNF)–mediated apoptosis in the liver. Here we tested the potential role of the K18 R89C mutation on Fas– or TNF–mediated apoptotic liver injury by injecting Fas antibody (Ab) or TNF–α plus actinomycin D into mice that overexpress wild–type (WT) human K18 (with intact filament network, termed TG2 mice) or into K18 R89C mice (with disrupted filament network). K18 R89C mice are significantly more susceptible to Fas–mediated liver injury compared with nontransgenic and TG2 mice. This included differences in lethality, histology, apoptosis, and serum transaminase levels. In contrast, K18 WT and R89C mice manifest similar sensitivity to TNF–induced injury. Both Fas– and TNF–induced apoptosis in liver tissues are associated with caspase–mediated K18 degradation and increased keratin phosphorylation on several but not all sites. In conclusion, transgenic mouse K18 mutation and its consequent keratin filament disruption predispose hepatocytes to Fas– but not TNF–mediated apoptotic injury. This supports the association of keratin mutations with cirrhosis in patients with liver disease and suggests that keratins modulate apoptosis induced by Fas but not TNF.
Reduced nonspecific bronchial reactivity and decreased airway response to antigen challenge in atopic asthmatic patients treated with the inhaled leukotriene D<sub>4</sub> antagonist, L‐648,051
Authors: J. B. Rasmussen, L.‐O. Eriksson, P. Tagari, E. G. Stahl, K.‐E. Andersson
Journal: Allergy (1992)

We studied the effect of the inhaled leukotriene D4 antagonist, L-648,051, on antigen-induced bronchoconstriction and nonspecific bronchial reactivity. Ten males with mild atopic asthma completed a double-blind, randomized, two-period, placebo-controlled cross-over study. For a 7-day period patients inhaled either placebo or 6 mg of L-648,051 four times daily. Bronchial reactivity to methacholine was measured at base line (day 1) and after 6 days, treatment (day 7). On day 8, after inhaling 6 mg of the antagonist (or placebo), the patients were challenged by inhaled antigen; they received an additional 6 mg of the antagonist (or placebo) 3 h later. Pulmonary function (forced expiratory volume in 1 s, FEV1) was measured serially through an 8-h post-antigen challenge. Nonspecific airway reactivity was again measured on day 9. Compared to placebo, L-648,051 treatment diminished the methacholine reactivity, on both day 7 (NS) and on day 9 (P < 0.05). In addition, the immediate and late bronchial responses to antigen challenge on day 8 were attenuated in the patients when treated with L-648,051. In the immediate phase (0-3 h postchallenge), the airway response was significantly reduced at all recordings between 20 min and 1 h postchallenge. In the late phase (3-8 h postchallenge), the pulmonary response was also reduced. However, the reduction was statistically significant only at the 5-h recording. The results suggest that sulfidopeptide leukotrienes are of importance for nonspecific airway reactivity, and that leukotriene D4 is a significant mediator in the immediate asthmatic reaction.
Studies of Cryoproteins in Systemic Lupus Erythematosus*
Authors: Lonnie B. Hanauer, Charles L. Christian
Journal: Journal of Clinical Investigation (1967)

Cryoproteins observed in patients with systemic lupus erythematosus were shown to be of "mixed type," consisting largely of IgG and IgM. The IgM moiety possessed anti-IgG globulin reactivity and precipitated in the cold after mixing with a source of IgG. The IgM fraction of one cryoprotein precipitated only with the same patient's IgG. Antisera prepared against purified cryoproteins regularly recognized IgM, IgG, the 11 S component of C', and alpha(2)-macroglobulin. C'4 (beta(1E)) and C'3 (beta(1C)) were recognized by four and two antisera, respectively. Antisera prepared against two cryoproteins reacted (after absorption) only with the sera of origin. These "unique" antigens were associated with IgM, were destroyed by mercaptoethanol treatment, and, in one patient, were shown to disappear subsequent to clinical improvement.
CORONARY ARTERY REMODELING AND PLAQUE COMPOSITION IN NON INFARCT RELATED CORONARY ARTERIES IN PATIENTS PRESENTING WITH ST SEGMENT ELEVATION MYOCARDIAL INFARCTION: WHERE IS THE NECROTIC CORE?
Authors: Rasmus Egede, Lisette O. Jensen, Gary S. Mintz, Knud N. Hansen, Knud E. Pedersen, Anders Junker, Henrik S. Hansen, Per Thayssen
Journal: Journal of the American College of Cardiology (2010)
Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodelling in hypertension in rats
Authors: D Badenhorst
Journal: Cardiovascular Research (2003)

Objective: To assess whether the variable impact of quantitative changes in myocardial collagen on left ventricular (LV) diastolic myocardial stiffness (myocardial k) and remodelling (increased volume intercept of diastolic pressure–volume relations) in LV hypertrophy (LVH) is associated with alterations in myocardial collagen cross-linking. Methods: We evaluated myocardial collagen content (hydroxyproline concentrations [HPRO]) and the degree of myocardial collagen cross-linking (solubility to cyanogen bromide digestion) in 14–15- and 21–22-month-old spontaneously hypertensive rats (SHRs), and in aortic-banded rats with pressure overload hypertrophy (POH). Results: In rats with POH and in SHRs irrespective of age, increases in myocardial [HPRO] were noted. However, hypertensive rats differed in the material and geometric properties of the myocardium, and in qualitative aspects of fibrosis. In 14–15-month-old SHRs myocardial k (determined from diastolic stress–strain relations) and insoluble (cross-linked) [HPRO] were increased, but no LV remodelling or increases in myocardial soluble (non-cross-linked) [HPRO] were noted. In rats with POH, LV remodelling and increases in soluble myocardial [HPRO] occurred, but no increase in k or insoluble myocardial [HPRO] were observed. In 21–22-month-old SHRs, increases in k, soluble and insoluble myocardial [HPRO], as well as LV remodelling occurred. Conclusions: Collagen cross-linking may determine the diverse relation that exists between increases in myocardial collagen concentrations and either myocardial stiffness or chamber remodelling in hypertension. These findings support the notion that fibrosis contributes to myocardial stiffness as well as LV dilatation in LVH, albeit an effect that is modulated by collagen quality.
FREQUENCY OF CONDUCTION DISTURBANCES AFTER PERCUTANEOUS BALLOON AORTIC VALVULOPLASTY
Authors: Ana Laynez Carnicero, Itsik Ben-Dor, Kohei Wakabayashi, Rafael Romaguera, Manuel A. Gonzalez, Gabriel Sardi, Michael A. Gaglia, Michael Mahmoudi, Gabriel Maluenda, Rebecca Torguson, Zhenyi Xue, William O. Suddath, Lowell F. Satler, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2011)
Abstract IA9: Pathway-directed therapy
Authors: Douglas A. Levine
Journal: Clinical Cancer Research (2013)

Abstract The Cancer Genome Atlas (TCGA) has recently completed its first formal analysis of the genomic and clinical data from the ovarian carcinoma project. The landscape of ovarian cancer is changing due to our improved understanding of risk factors, histopathology, and cancer genomics. Ovarian cancer is a unique disease with extensive activation of canonical cancer pathways. This session will update the latest advances in ovarian cancer research with a focus on pathway-based therapeutics. The incorporation of biomarkers to predict clinical outcome and for the selection of molecularly targeted agents will be examined. Throughout the session examples will be provided from recent literature and clinical trials. At the conclusion of the session, the participants should have a better understanding of the latest molecular progress and the application to screening, prevention, and therapeutic stratification. Citation Format: Douglas A. Levine. Pathway-directed therapy. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr IA9.