tbuckley/cabot-search huggingface dataset:
Use of Fingertip Blood in Detection of Rheumatoid Factor
Authors: Irwin Oreskes
Journal: JAMA (1966)

Rheumatoid factor originally demonstrated in sera from patients with rheumatoid arthritis is now known to be present in many other conditions. Among these are leprosy, hepatic disorders, connective-tissue diseases, subacute bacterial endocarditis, sarcoidosis, and syphilis. (Communications by Vaughn<sup>1</sup>and Singer<sup>2</sup>are general reviews.) Rheumatoid factor has also been found in a small percentage of normal, healthy populations and in a high percentage of residents of homes for the aged.<sup>3</sup>As a consequence, there has been increasing interest in recent years in surveying various other populations (eg, ethnic, occupational, and disease) for the presence of rheumatoid factor. In many of these investigations, the latex fixation test of Singer and Plotz,<sup>4</sup>or some variation of it, has been used for rheumatoid factor detection. However for studying large groups of patients, the majority of who would show negative results, this test may be tedious and time consuming. In an
Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity.
Authors: A Welling, Y W Kwan, E Bosse, V Flockerzi, F Hofmann, R S Kass
Journal: Circulation Research (1993)

At least four calcium channel subtypes (P, T, N, and L) have now been classified on the basis of their biophysical and/or pharmacological properties. L-type channels, a channel family particularly important to physiological function of the cardiovascular system, are identified by their slow voltage- and calcium-dependent inactivation as well as their sensitivity to dihydropyridine (DHP) calcium channel antagonists. In this study, we report the results of experiments in which we have measured the DHP modulation of recombinant calcium channel activity in cells transfected with alpha 1 subunits of cardiac and smooth muscle L-type calcium channels. We find subunit-dependent differences in the voltage and concentration dependence of channel modulation. Our results provide evidence for a molecular basis for DHP sensitivity of heart and smooth muscle calcium channels and, additionally, indicate that, even within one family of calcium channels, slight differences in channel structure can cause marked differences in channel pharmacology.
Military Medicine Responds to Terrorism
Authors: Phil Gunby
Journal: JAMA (1996)

MENTAL HEALTH teams from Landstuhl (Germany) Regional Army-Air Force Medical Center are working with survivors of the terrorist bombing of the Khobar Towers US military housing complex in Dhahran, Saudi Arabia. At the same time, the approximately 20 000 US military people serving in the Persian Gulf area are bracing for possible further terrorism. Military medical personnel are reviewing emergency support plans. Some of this emergency medical planning was put into effect promptly after the housing in Dhahran's al-Khobar suburb was blasted by a truck bomb. Forward Area Surgical Teams from Ramstein (Germany) and Incirlik (Turkey) bases rushed to the scene. And a Critical Care Augmentation Transport Team that was supporting North Atlantic Treaty Organization peace enforcers in Bosnia-Herzegovina moved into standby position. Some 30 US Air Force medical personnel already were stationed at the Dhahran area King Abdul Aziz Air Base staging site, including 4 physicians. One flight surgeon
Appraisal of Methysergide in Treatment of Vascular Headaches of Migraine Type
Authors: Arnold P. Friedman
Journal: JAMA (1963)

The authors administered methysergide maleate to 421 patients who previously had been treated, without success, for recurrent headaches over periods as long as 55 yr. The drug was given in amounts ranging from 6 to 16 mg per day in divided doses. The treatment, essentially prophylactic, was continued for periods up to 29 mo. Side effects were frequent and adjustment of dosage was necessary. The data led to the conclusion that methysergide maleate has no value in treating the acute attack, but is effective in the prophylactic treatment of all forms of migraine headache.
Diagnosis of Invasive Pulmonary Aspergillosis
Authors: Crawford Chung
Journal: JAMA (1978)

A TRANSBRONCHIAL lung biopsy specimen confirmed a diagnosis of invasive pulmonary aspergillosis, a condition that has hitherto required more invasive diagnostic techniques. <h3>Report of a Case</h3> A 55-year-old man had a six-month history of increasing cough and sputum production and a four-day history of fever and chills. He had been treated for active pulmonary tuberculosis 18 years and again nine years previously. Chest roentgenograms since eight years before admission showed only minimal apical scarring on the left without any other abnormality. He was a cachectic, chronically ill man with a temperature of 39 °C. The hematocrit level was 32.7%; WBC count, 22,000/cu mm, with 37% bands, 44% segmented forms, 9% lymphocytes, 3% eosinophils, and 7% monocytes. The serum electrolyte level was normal. There was a left upper lobe cavity on the chest roentgenogram with surrounding infiltration (Fig 1). No fungus balls were seen. Sputum smears were repeatedly negative for acid-fast
Rituals in antenatal care. Women should understand the need for change.
Authors: G Chamberlain
Journal: BMJ (1993)

Rituals in antenatal careConsider women's psychosocial needs EDITOR,-We welcome Philip Steer's call to dis- card outdated rituals in antenatal care and to explore more promising interventions.'A con- siderable body of evidence casts doubt on many of the procedures carried out in antenatal consultations; the work of Hall et al in Aberdeen2 and comparative evidence from Europe3 suggest that fewer antenatal visits may be acceptable.However, we would urge caution on two counts before the schedule of visits is changed.Firstly, although the experience in Aberdeen is reassuring, as is that of a trial in Zimbabwe (S P Munjanja, conference on the Royal College of Obstetricians and Gynaecologists and safe motherhood, 13-14 July 1992), there are no results from randomised controlled trials of different schedules ofvisits in Britain.Perhaps more importantly, any proposed changes in the schedule of antenatal visits should be shown to meet women's psychosocial needs as well as to be clinically safe.Although trials of social support have not shown any great effects on traditional clinical outcomes, the evidence shows that "supported mothers are more likely . . . to feel 'in control' during pregnancy and postpartum, to be satisfied with their medical care, not to feel unhappy after the birth, to have partners who feel involved with the baby, to be breastfeeding, to report physical well-being and to have babies with fewer worrying health problems."4If the number of antenatal visits is reduced without these important measures being taken into account, benefits may be lost.We are currently conducting a randomised controlled trial of a reduction in the number of antenatal visits for low risk women.We hope that this will provide helpful information about the clinical and psychosocial effectiveness of different schedules ofvisits.
When to stop a clinical trial.
Authors: E. J. Neale
Journal: BMJ (1992)

risk.In many cases the equipment, if issued after certain dates, must comply with agreed European or national standards.These new regulations will operate alongside some of the existing legislation, such as the Control of Substances Hazardous to Health Regulations, which already require employers to protect employees from such hazardous substances as glutaraldehyde, anaesthetic gases, infected blood, and other body tissues.4Accident and emergency staff who do not wear suitable personal protective equipment may therefore be in breach of new health and safety legislation, specifically the Personal Protective Equipment at Work Regula- tions and, generally, the Health and Safety at Work, etc, Act 1974 and the proposed "general provisions" regulations.It is rumoured that when the general provisions regulations are finally agreed they will be renamed the Management of Health and Safety at Work Regulations, which would put the onus of compliance for health and safety on management.
A Parathyroid Cyst with Adenoma on Thallium-201/Technetium-99m Subtraction Imaging
Authors: KWANG G. JOO, GEORGE R. BAEUMLER
Journal: Clinical Nuclear Medicine (1987)

A case of a parathyroid cyst with adenoma was seen on TI-201/Tc-99m subtraction imaging. The literature regarding parathyroid cysts and the subtraction technique for parathyroid adenoma imaging was reviewed.
Negotiators explain flexible training under the new deal
Authors: N. Mamode
Journal: BMJ (2002)

EDITOR—We led the team that negotiated the new pay deal for junior doctors and read Davies and Eaton's criticisms.1 They seem to believe we obtained too much money for flexible trainees. Many doctors who were previously paid less than their childminder to combine a career in medicine and a family might disagree.

Band 3 (non-compliant posts under the new deal) is intended to be a penal rate for trusts. Both sides involved in negotiating the deal believed that as flexible trainee posts are supernumerary nothing should prevent …
Water Hardness and Heart Disease
Authors: J. R. Marier
Journal: JAMA (1981)

<h3>To the Editor.—</h3> In a recent COMMENTARY, Hammer and Heyden (1980;243:2399) have concluded that any postulated interrelation between water hardness and heart disease is unjustifiable. However, in all discussions of this topic, the essential thing to remember is that regional geochemical factors can influence the proportionality of the waterborne magnesium-vs-calcium interrelation, and this means that a given "water hardness" designation can denote waters of extremely different composition when one is comparing distinct geographic localities. Therefore, absolute reliance on water hardness per se is contraindicated. Recent studies in Canada and elsewhere have demonstrated that some aspects of this "water story" are indeed valid.<sup>1</sup>This recent approach does not rely strictly on the water hardness factor but emphasizes individual waterborne elements, along with consideration of myocardial tissue composition and food-beverage dietary intake of the individual elements (and their interrelation). In such a context, it is possible to demonstrate why the
Advances in International Maternal and Child Health
Authors: Stephen C. Joseph
Journal: JAMA (1982)

<i>Advances in International Maternal and Child Health</i>, volume 1, edited by D. B. Jelliffe and E. F. Patrice Jelliffe, is envisaged as the first of a series "with the intention of drawing together up-to-date information on major conditions affecting the health of mothers and young children from a global point of view." In this difficult task, made more complex by the need to give primacy to the problems of mothers and children in less-developed countries, the editors and authors have succeeded admirably; it is to be hoped that this will be the initial volume of an annual series. Each chapter in the volume is written by a recognized authority in the field. Among the topics covered that will be of special interest to US physicians are chapters on immunization, adolescent reproductive health, an overview of family planning issues, two excellent chapters on oral rehydration, one on low-birth-weight infants, and two
Validation of a Model to Identify Young Patients for Lymph Node Biopsy
Authors: Gail B Slap, James L. Connor, Robert S. Wigton, J. Sanford Schwartz
Journal: JAMA (1986)

A model to identify 9- to 25-year-old patients with malignant or granulomatous lymphadenopathy demonstrated a sensitivity/specificity of 0.95/0.96 in the original sample. This study tests the performance of the model in three new samples (n=34, 87, 46) of young patients with peripheral lymphadenopathy. Patient charts were reviewed for the biopsy diagnosis and for the three variables in the model (lymph node size, recent ear-nose-throat symptoms, and chest roentgenogram). Prevalence rates of malignancy or granuloma in the three samples were 0.71, 0.37, and 0.37. The model's sensitivity/specificity in the three samples were 0.96/1.00, 0.88/0.80, and 0.82/0.83. Receiver operating characteristic curve areas for the model ranged from 0.87 to 0.98, indicating excellent discrimination. Likelihood ratios were calculated for all scores to allow adjustment of the model's predictions for population differences in the prevalence of malignancy or granuloma. We conclude that the model performs well and can help physicians to select those young patients with peripheral lymphadenopathy who should undergo biopsy. (<i>JAMA</i>1986;255:2768-2773)
Considerations for Attending Rounds
Authors: Paul Bergl, Vineet Arora, Jeanne Farnan
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Conserved Higher-Order Chromatin Regulates NMDA Receptor Gene Expression and Cognition
Authors: Rahul Bharadwaj, Cyril J. Peter, Yan Jiang, Panos Roussos, Annie Vogel-Ciernia, Erica Y. Shen, Amanda C. Mitchell, Wenjie Mao, Catheryne Whittle, Aslihan Dincer, Mira Jakovcevski, Venu Pothula, Theodore P. Rasmussen, Stella G. Giakoumaki, Panos Bitsios, Ajfar Sherif, Paul D. Gardner, Patricia Ernst, Subroto Ghose, Pamela Sklar, Vahram Haroutunian, Carol Tamminga, Richard H. Myers, Kensuke Futai, Marcelo A. Wood, Schahram Akbarian
Journal: Neuron (2014)
Operability in Bronchogenic Carcinoma-Reply
Authors: Irwin L. Stoloff
Journal: JAMA (1975)

In Reply.—  Drs Gueldner and Lawrence raise the question of operability on patients with an endoscopic biopsy-demonstrated cancer and state that they have observed seven long-term, clinically cancer-free patients among that group. My observations suggest that, in terms of long-term survival, a better discriminant could be obtained in their series were they to isolate all cancers located within the main stem bronchi (227:299, 1974). Using the date of roentgenographic detection as the date of entry into the study, the five-year survival for such persons was 2%. This meant one long-term survivor of 132 persons with main stem lesions, and this patient lived five years from the date of x-ray diagnosis, without a surgical resection. When one looks at persons with tumors distal to the main stem bronchus, such as those in peripheral bronchi, with bronchoscopic abnormalities other than the detection of a tumor, or persons with normal bronchoscopic findings, the
A New Evacuator.
Authors: M. G. Sloan
Journal: JAMA (1895)

Dexter, Iowa, June 9, 1895. <h3>To the Editor:</h3> —Having had occasion a few months since to use Bigelow's evacuator in doing the operation of litholapaxy, I discovered the instrument was sadly defective in the manner of the connection between the rubber bulb and the glass bulb for receiving the<i>débris</i>; it being made by securing the rim of the glass bulb to a metallic ring by means of plaster-of-Paris; this metallic ring being in turn adjusted to the metal connection of the lower end of the rubber bulb by means of a bayonet joint on one side only. After evacuating about half of the crushed stone from the bladder, I found that there was a large leak from the plaster-of-Paris joint, as well as a smaller one from the bayonet joint above. The leak increased so rapidly that in a few moments more the instrument became practically useless and I
Ectodermal dysplasia–skin fragility syndrome resulting from a new homozygous mutation, 888delC, in the desmosomal protein plakophilin 1
Authors: Sibel Ersoy-Evans, Gül Erkin, Hiva Fassihi, Ien Chan, Amy S. Paller, Selçuk Sürücü, John A. McGrath
Journal: Journal of the American Academy of Dermatology (2006)
EFFECTS OF GLYCOPROTEIN IIB/IIIA INHIBITORS IN COMBINATION WITH VORAPAXAR, A PLATELET THROMBIN-RECEPTOR ANTAGONIST, AMONG PATIENTS WITH NON-ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROMES: INSIGHTS FROM THE TRACER TRIAL
Authors: J.H. Cornel, Pierluigi Tricoci, john Horton, David Moliterno, Lars Wallentin, Paul Armstrong, Philip Aylward, Zhen Huang, Yuliya Lokhnygina, Edmond Chen, Sergio Leonardi, Frans Van de Werf, Harvey White, Claes Held, John Strony, Kenneth Mahaffey, Robert Harrington
Journal: Journal of the American College of Cardiology (2013)
Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation.
Authors: M-C. Gonzalez, C. Marteau, J. Franchi, D. Migliore-Samour
Journal: British Journal of Dermatology (2001)

Journal Article Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation Get access M‐C. Gonzalez, M‐C. Gonzalez FRE 2134 CNRS, GNC, Institut de Transgénose, 3b rue de la Férollerie, 45071, Orléans cedex 2, France *Laboratoire de Recherche et Développement, LVMH Branche Parfums et Cosmétiques, 45804, Saint Jean de Braye cedex, France Search for other works by this author on: Oxford Academic Google Scholar C. Marteau, C. Marteau FRE 2134 CNRS, GNC, Institut de Transgénose, 3b rue de la Férollerie, 45071, Orléans cedex 2, France *Laboratoire de Recherche et Développement, LVMH Branche Parfums et Cosmétiques, 45804, Saint Jean de Braye cedex, France Search for other works by this author on: Oxford Academic Google Scholar J. Franchi, J. Franchi FRE 2134 CNRS, GNC, Institut de Transgénose, 3b rue de la Férollerie, 45071, Orléans cedex 2, France *Laboratoire de Recherche et Développement, LVMH Branche Parfums et Cosmétiques, 45804, Saint Jean de Braye cedex, France Search for other works by this author on: Oxford Academic Google Scholar D. Migliore‐Samour D. Migliore‐Samour FRE 2134 CNRS, GNC, Institut de Transgénose, 3b rue de la Férollerie, 45071, Orléans cedex 2, France *Laboratoire de Recherche et Développement, LVMH Branche Parfums et Cosmétiques, 45804, Saint Jean de Braye cedex, France Dr D.Migliore‐Samour.E‐mail: migliore@cnrs‐orleans.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 5, 1 November 2001, Pages 749–757, https://doi.org/10.1046/j.1365-2133.2001.04490.x Published: 01 November 2001
Detection of Finger Clubbing and Primary Lung Tumor on Tc-99 MDP Bone Scintigraphy in a Patient With a Scaphoid Fracture
Authors: Hosahalli K. Mohan, Ashley M. Groves, Susan E.M. Clarke
Journal: Clinical Nuclear Medicine (2004)

Clubbing of the fingers has a myriad of causes. It is a well-recognized paraneoplastic phenomenon in nonsmall cell carcinoma of the lung. The pathogenesis is still not fully understood, but it is associated with increased vascularity in the nail beds. The authors present a Tc-99 MDP bone scintigram illustrating clubbing in the hand, a primary lung tumor, as well as the underlying bony abnormality. The case emphasizes the importance of vigorously exploring the nonskeletal components of bone scintigraphy.
An elderly woman with obstruction
Authors: A. Tilley, A. Khanafer, A. Chakrabarty, R. Balasubramaniam, P. Waterland, T. Fox
Journal: BMJ (2009)

A thin, 87 year old, white woman presented with absolute constipation that had lasted for three days, abdominal pain, and vomiting. She also complained of a severe pain in her right thigh radiating to the knee. She had no preceding bowel symptoms, but she reported bouts of vomiting and abdominal pain lasting several days for the previous 18 months. The patient was unsure of recent weight loss. She lived alone and was independent, although her daughter helped with shopping. Medical history included osteoporosis and occasional dyspepsia. The patient had no history of any abdominal surgery. Medications were weekly risedronate and daily omeprazole. On examination she had a distended and tender abdomen with no palpable masses or hernias. Bowel sounds were high pitched and “tinkling.” She also demonstrated right sided painful hip flexion. Abdominal radiography revealed dilated loops of small bowel suggestive of obstruction, and computed tomography of the abdomen was requested (fig 1⇓). Fig 1 Computed tomogram of the patient’s abdomen ### Short answers
A METHOD FOR DETERMINING THE DIFFERENTIAL SEDIMENTATION OF PROTEINS IN THE HIGH SPEED CONCENTRATION CENTRIFUGE
Authors: Thomas P. Hughes, Edward G. Pickels, Frank L. Horsfall
Journal: The Journal of Experimental Medicine (1938)

A method is presented for determining the relative degree of sedimentation of proteins and other small particles, either in pure form or in a mixture, utilizing the concentration centrifuge of Bauer and Pickels. Chemical analysis or biological assay of material obtained at different fluid levels by means of a special sampling device is used to measure the degree of sedimentation. The results are reproducible within 10 per cent and, under the conditions of the experiments cited, are characteristic for the proteins thus far investigated.
Spasm of a normal or minimally narrowed coronary artery in the presence of severe fixed stenoses of the remaining vessels: clinical and angiographic observations.
Authors: P Mercurio, I Kronzon, H Winer
Journal: Circulation (1982)

Four patients with medically refractory unstable angina are presented. Each patient had ST-segment abnormalities during some episode of pain. Three patients had at least one episode of documented ST-segment elevation with their spontaneously occurring chest pain. One had recurrent ventricular tachycardia. Two patients had prior myocardial infarction. Angiography demonstrated localized left ventricular akinesis and a severe fixed stenosis in the coronary artery supplying the abnormal segment. There were severe, fixed lesions in two coronary arteries in two patients and in one vessel in two patients. After i.v. ergonovine maleate, coronary artery spasm was documented in a normal or minimally diseased coronary artery in each patient. In two patients, ergonovine-induced spasm not only occluded the vessel, but also markedly decreased retrograde filling of a vessel with severe, fixed narrowing. Each patient's characteristic symptoms appeared with the ergonovine-induced spasm. Thus, ergonovine maleate can provoke spasm of a normal coronary artery, even in the presence of severe fixed stenoses of the remaining vessels. This observation may have an important role in the diagnosis and clinical management of patients with chest pain.