tbuckley/cabot-search huggingface dataset:
Survey of neuroleptic prescribing in residents of nursing homes in Glasgow
Authors: A. M McGrath, G. A Jackson
Journal: BMJ (1996)

Poor cognitive performance has been associated with increased mortality in several studies of elderly people, but the underlying mechanisms are unclear * In this prospective study of 921 elderly people cognitive impairment was a strong predictor of death from ischaemic stroke * Low vitamin C intake and low plasma ascorbate concentrations were also important risk factors for death from stroke * Cognitive performance was poorest in people with the lowest vitamin C status * A high vitamin C intake may protect against both cognitive impairment and cerebrovascular disease showed that intake of the antioxidant vitamin C was a strong predictor of subsequent death from stroke.8This finding, together with the known link between atherosclerosis and cognitive impairment, suggests that subclinical deficiency of vitamin C may be a determinant rather than a consequence of impaired cognitive function in elderly people.Declining cognitive function and cerebrovascular disease are both common in old people.The results of this study tend to support the view that a considerable proportion of cognitive decline in the elderly popu- lation is vascular in origin.They also suggest that a high vitamin C intake, perhaps by an antiatherogenic mechanism, protects against both cognitive impair- ment and cerebrovascular disease.This may have important implications for prevention.We thank the Department of Health for allowing us to use data from the 1973-4 Department of Health and Social Security's nutritional survey.We are grateful to David Coggon and Clive Osmond of the MRC's environmental epidemiology unit for advice and to Paul Winter for help with computing.The DHSS survey was coordinated by the late Professor A N Exton-Smith, and the biochemical analyses were carried out by Joan Stephen.
Adenosine does not evoke pain from venous and paravascular nociceptors in the human
Authors: W. Klement, J. O Arndt
Journal: Cardiovascular Research (1992)

Objective: The pain evoking and pain modulating properties of adenosine were studied at venous and paravascular nociceptors in humans. Methods: In six volunteers, adenosine (3 to 15·10−3 M) was perfused continuously through vascularly isolated segments of dorsal hand veins or injected into occluded finger veins. The effects of adenosine on pain evoked by intravenous electrostimulation of hand veins were also studied. The subjects rated the pain intensities on a visual analogue scale. Results: Adenosine neither evoked pain nor altered the intensities of electrically evoked pain. Conclusions: Adenosine does not mediate or modulate pain via venous or paravascular nociceptors. Therefore these nociceptors are unlikely to be involved in adenosine related ischaemia pain.
What's in a structure?
Authors: Virgil Whitmyer
Journal: Behavioral and Brain Sciences (2001)

Shepard's general approach provides little specific information about the implementation of laws in brains. Theories that turn on an isomorphism between some domain and the brain, of which Shepard's is one, do not provide specific detail about the implementation of the structures they propose. But such detail is a necessary part in an explanation of mind. [Shepard]
After Bakke, What?
Authors: Carlton P. Alexis
Journal: JAMA (1978)

AFTER several weeks of great anticipation and expectation, on June 28, 1978, the Supreme Court of the United States handed down its decision in the case of the<i>Regents of the University of California vs Bakke</i>. If I understand this decision, I think it is fair to state that it was twofold. On the one hand, it directed that Bakke be admitted to the Medical School of the University of California at Davis; on the other hand, it stated that race may be considered as one factor in university admissions procedures. The reactions to the Court's decision ran the full gamut of statements and emotions. Some have believed that the Court's decision was a masterpiece of judicial statesmanship, and that while it provided Bakke with victory, it permitted the continuation of what have come to be known as "affirmative action programs." However, there are others who have believed that the
Fatal Suppurative Cholangitis without Obstruction
Authors: A. Gee
Journal: BMJ (1953)

are unusual neurological signs such as were found in the present case; in this event, adequate antisyphilitic treatment may help in averting further progress of the disease and bring clinical improvement.Summary A case of the Parkinsonian syndrome apparently due to congenital syphilis is described.The response to treatment has been satisfactory.Although syphilis is a rare cause of the condition it should be considered when the Parkinsonian syndrome develops in the 30-50 age group, particularly if there are any anomalous clinical features.I thank Dr. G. McComas for permission to publish the case and for advice
INDUSTRIAL DERMATITIS AND THE WORKMEN'S COMPENSATION ACT.*
Authors: H. MACCORMAC
Journal: British Journal of Dermatology (1937)

Journal Article INDUSTRIAL DERMATITIS AND THE WORKMEN'S COMPENSATION ACT. Get access H. MACCORMAC, C.B.E., M.D., F.E.C.P. H. MACCORMAC, C.B.E., M.D., F.E.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 49, Issue 10, 1 October 1937, Pages 409–422, https://doi.org/10.1111/j.1365-2133.1937.tb10374.x Published: 01 October 1937
Treatment of Toxemia of Pregnancy
Authors: Richard P. Perkins
Journal: JAMA (1977)

<h3>To the Editor.—</h3> In the recent communication by Keith (237:1570, 1977), once again the spectre of the use of diazoxide in the treatment of hypertension associated with pregnancy has been raised. Several misconceptions regarding the nature of toxemia in pregnancy have led the author to conclude that occasions may arise in which the use of diazoxide may be justifiable. In a recent communication<sup>1</sup>we have outlined several objections to the use of diazoxide in hypertensive conditions associated with pregnancy and would wish to acquaint those who might have been persuaded by Keith's suggestions regarding these potential problems. The author himself comments that there is the risk of a sudden drop in blood pressure associated with the use of diazoxide. This risk is a clear and present danger to the fetus, which is already severely compromised by restricted uterine perfusion. It is the majority opinion of those obstetrician-gynecologists who are knowledgeable
Birth weight, current body weight, and blood pressure.
Authors: A Grulich
Journal: BMJ (1991)

though the drug had been stopped several years previously.4More recently 25% of 60 patients given thalidomide to manage chronic discoid lupus erythematosus were reported to have developed thalidomide neuropathy5 and all eight patients given thalidomide for nodular prurigo and aphthous stomatitis were found to have a neuro- pathy.6Despite warnings," thalidomide has been used for over 20 years to manage erythema nodosum leprosum, and Waters states that "thalidomide peripheral neuropathy has not yet been reported" in such patients.4This statement requires clari- fication.Is it implying that neuropathy does not occur in patients with erythema nodosum leprosum given the drug or is it that Waters and leprologists who use thalidomide are unable to detect symptoms and signs of nerve damage?
Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
Authors: Romain Micol, Samer Kayal, Nizar Mahlaoui, Julien Beauté, Pauline Brosselin, Yasmine Dudoit, Gaëlle Obenga, Vincent Barlogis, Nathalie Aladjidi, Kamila Kebaili, Caroline Thomas, Fabienne Dulieu, Fabrice Monpoux, Raphaële Nové-Josserand, Isabelle Pellier, Olivier Lambotte, Alexandra Salmon, Agathe Masseau, Pierre Galanaud, Eric Oksenhendler, Marie-Dominique Tabone, Pierre Teira, Hélène Coignard-Biehler, Fanny Lanternier, Olivier Join-Lambert, Gaël Mouillot, Ioannis Theodorou, Jean-Claude Lecron, Marie-Alexandra Alyanakian, Capucine Picard, Stéphane Blanche, Olivier Hermine, Felipe Suarez, Marianne Debré, Marc Lecuit, Olivier Lortholary, Anne Durandy, Alain Fischer
Journal: Journal of Allergy and Clinical Immunology (2011)
Castleton Medical College
Authors: Charles Haines
Journal: JAMA (1968)

To the Editor:—  I have read with pleasure the story of Castleton Medical College ( 204 :698,1968). As you probably know the medical college at Woodstock, Vt, like that at Castleton, contributed much to the life of Vermont and New England. The memory of these institutions ought to be kept alive.  These two medical colleges sent comparatively well-trained physicians out into the state to care, as best they could, for the people. I sometimes wonder whether one can say as much for most of our modern American medical schools!  I hope that a goodly number of people will be stimulated by your article to contribute money to save the chapel.
Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes
Authors: Linda Yip, Leon Su, Deqiao Sheng, Pearl Chang, Mark Atkinson, Margaret Czesak, Paul R Albert, Ai-Ris Collier, Shannon J Turley, C Garrison Fathman, Rémi J Creusot
Journal: Nature Immunology (2009)
Significance of Phlebography in Phlebothrombosis
Authors: Michael E DeBakey, George F Schroeder, Alton Ochsner
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reflections on Histamine, Gastric Secretion and the H<sub>2</sub>Receptor
Authors: Charles F. Code
Journal: New England Journal of Medicine (1977)

"Histamine, that decarboxylated son of histidine" — these poetic words of Carl Dragstedt, the pharmacologist and brother of Lester, the great surgeon, express beautifully the frustrations and disappointments of all who are confirmed histamine addicts. And there are quite a few in the world today. Histamine has been one of my interests for over 40 years, and she has been a fickle mistress. She was discovered as a chemical curiosity in 1907, when she was synthesized in Germany by Windaus and Vogt.1 She was isolated from biologic sources, first from ergot and then from intestinal mucosa by Barger and Dale . . .
Primary Amyloidosis Presenting with a Confusing Clinical Picture
Authors: I. N. Lee
Journal: BMJ (1957)

A non-smokers.It cannot be concluded from these figures that penicillin reduces the risk of post-operative chest infections when given immediately before operation.TABLE III Penicillin No Penicillin Severe post-operative chest complications 27 30 Mild post-operative chest 15 23 No change post-operatively .. ..
Antibody Conjugate Therapeutics: Challenges and Potential
Authors: Beverly A. Teicher, Ravi V.J. Chari
Journal: Clinical Cancer Research (2011)

Antibody conjugates are a diverse class of therapeutics consisting of a cytotoxic agent linked covalently to an antibody or antibody fragment directed toward a specific cell surface target expressed by tumor cells. The notion that antibodies directed toward targets on the surface of malignant cells could be used for drug delivery is not new. The history of antibody conjugates is marked by hurdles that have been identified and overcome. Early conjugates used mouse antibodies; cytotoxic agents that were immunogenic (proteins), too toxic, or not sufficiently potent; and linkers that were not sufficiently stable in circulation. Investigators have explored 4 main avenues using antibodies to target cytotoxic agents to malignant cells: antibody-protein toxin (or antibody fragment-protein toxin fusion) conjugates, antibody-chelated radionuclide conjugates, antibody-small-molecule drug conjugates, and antibody-enzyme conjugates administered along with small-molecule prodrugs that require metabolism by the conjugated enzyme to release the activated species. Only antibody-radionuclide conjugates and antibody-drug conjugates have reached the regulatory approval stage, and nearly 20 antibody conjugates are currently in clinical trials. The time may have come for this technology to become a major contributor to improving treatment for cancer patients.
The effect of different reference transducer positions on intra-abdominal pressure measurement: a multicenter analysis
Authors: Jan J. De Waele, Inneke De laet, Bart De Keulenaer, Sandy Widder, Andrew W. Kirkpatrick, Adrian B. Cresswell, Manu Malbrain, Zsolt Bodnar, Jorge H. Mejia-Mantilla, Richard Reis, Michael Parr, Robert Schulze, Sonia Compano, Michael Cheatham
Journal: Intensive Care Medicine (2008)
The role of 1 alpha, 25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria.
Authors: R A Kaplan, M R Haussler, L J Deftos, H Bone, C Y Pak
Journal: Journal of Clinical Investigation (1977)

The cuase for the intestinal hyperabsorptionof calcium (Ca) in various forms of hypercalciurias was explored by a careful measurement of plasma 1 alpha, 25-dihydroxycholecalciferol [1 alpha, 25-(OH)I D] and by an assessment of intestinal Ca absorption and of parathyroid function. In 18 cases of primary hyperparathyroidism (PHPT), the mean plasma concentration of 1 alpha, 25-(OH)2D was significantly increased (4.9 +/- 2.2 SD ng/dl vs. 3.4 +/- 0.9 ng/dl for the control group), and was significantly correlated with fractional Ca absorption (alpha) (r = 0.80, P less than 0.001). Plasma 1 alpha, 25-(OH)2D was also correlated with urinary Ca (P less than 0.05), but not with serum Ca or phosphorus (P), P clearance, urinary cyclic AMP, or serum immunoreactive parathyroid hormone. In 21 cases of absorptive hypercalciuria (AH), plasma 1 alpha, 25-(OH)2D was elevated in one-third of cases, and the mean value of 4.5 +/- 1.1 ng/dl was significantly higher than that of the control group (P less than 0.01). Since relative hypoparathyroidism may be present, the normal absolute value of plasma 1 alpha, 25-(OH)2D, found in two-thirds of cases of AH, may be considered to be inappropriately high. Moreover, in the majority of cases of AH, the data points relating plasma 1 alpha, 25-(OH)2D and alpha fell within 95% confidence limits of values found in non-AH groups (including PHPT). The results suggest that the intestinal hyperabsorption of Ca in PHPT aw AH may be vitamin D dependent. However, the disturbance in vitamin D metabolism may not be the sole cause for the high Ca absorption in AH, since in some patients with AH, the intestinal Ca absorption appears to be inapp
Menopause-Dependent Plasma Lipoprotein Alterations in Diuretic-Treated Women
Authors: KURT BOEHRINGER
Journal: Annals of Internal Medicine (1982)

The effects of chlorthalidone, 100 mg/d given for 6 weeks, on serum lipids and lipoproteins were assessed in 22 premenopausal and 18 postmenopausal women. In the latter, chlorthalidone significantly increased total serum cholesterol (13%, p < 0.001), low-density-lipoprotein (LDL) cholesterol (21%, p < 0.001) and apoprotein B (16%, p < 0.05). In contrast, these values were not altered in the premenopausal group. Levels of LDL cholesterol, high-density-lipoprotein cholesterol, total and very-low-density triglycerides, apoproteins A1 and A2, and plasma volume, plasma glucose, insulin, epinephrine, estradiol, and free fatty acids were unchanged in both groups. Chlorthalidone-induced changes in levels of LDL cholesterol did not correlate significantly with variations in blood pressure, plasma potassium, uric acid, renin, aldosterone, or norepinephrine levels. These findings indicate that the thiazide-like diuretic chlorthalidone increases serum LDL cholesterol in postmenopausal but not in premenopausal women.
Fat-suppressed breath-hold magnetic resonance coronary angiography.
Authors: W J Manning, W Li, N G Boyle, R R Edelman
Journal: Circulation (1993)

BACKGROUND The ability to image the coronary arteries noninvasively would represent an advance in patient care. We have developed a magnetic resonance (MR) angiographic technique that allows the acquisition of complete images of coronary flow within a single breath-hold. By this method, the feasibility of noninvasive MR coronary angiography was evaluated in 25 subjects, including 19 healthy adult volunteers and six patients after diagnostic coronary angiography. METHODS AND RESULTS Noninvasive MR coronary angiography was performed with a fat-suppressed ECG-gated gradient-echo sequence with k-space segmentation. Overlapping transverse sections were initially used to image coronary flow, with oblique images obtained after identification of proximal anatomy. The left main coronary artery was seen in 24 subjects (96%), with a mean diameter of 4.8 mm (range, 3.4-6.2 mm) and average length of 10 mm (range, 8-14 mm). The left anterior descending coronary artery was seen in 100% of subjects, with a mean proximal diameter of 3.6 mm (range, 2.6-4.3 mm) and for an average length of 44 mm (range, 28-93 mm). The left circumflex coronary artery was seen in 76% of subjects, with a mean proximal diameter of 3.5 mm (range, 2.6-4.3 mm) and for an average length of 25 mm (range, 9-42 mm). The right coronary artery was also identified in 100% of subjects, with a mean proximal diameter of 3.7 mm (range, 2.7-5.1 mm) and for an average length of 58 mm (range, 24-122 mm). Quantitative angiography of normal proximal segments demonstrated a good correlation with MR-determined lumen diameters (r = 0.86, p &lt; 0.002). Occluded vessels in patients with coronary artery disease displayed an absence of flow signal distal to the occlusion, whereas vessels with significant angiographic stenoses demonstrated signal loss corresponding to the area of the stenosis, with visualization of the more distal vessel. CONCLUSIONS Breath-hold MR coronary angiography provides visualization of the major epicardial vessels. In the future, MR coronary angiography may provide a noninvasive means for the evaluation of patients with known or suspected coronary artery disease.
Hormone scandal hits France
Authors: A. Dorozynski
Journal: BMJ (1997)

Thousands of doses of potentially contaminated growth hormone were distributed in France nine months after the warning that its administration to children could cause Creutzfeldt-Jakob disease.

A judicial investigation has identified several former officials and the charges against them may be upgraded from involuntary homicide to poisoning.

In France about 1500 children were treated with growth hormone between February 1984 and February 1986. The hormone was purified at the Pasteur Institute …
Oral Minocycline in Treatment of Cutaneous Sarcoidosis
Authors: Talora Steen, Joseph C. English
Journal: JAMA Dermatology (2013)

Currently, therapeutic techniques used to treat cutaneous sarcoidosis rely on limited data from evidenced-based research.1- 2 Bachelez et al3 conducted a prospective study in which 10 of 12 patients showed improvement after minocycline therapy, and Antonovich and Callen4 reported the case of 1 woman who was successfully treated with doxycycline. On the basis of these encouraging reports, our clinic began to use minocycline, a commonly used anti-inflammatory acne therapy that does not require laboratory monitoring, as a first-line treatment for cutaneous sarcoidosis. The present retrospective study sought to evaluate our experience with minocycline treatment and to compare its effectiveness across sex and race.
Some notes on priming, alignment, and self-monitoring
Authors: Niels O. Schiller, Jan Peter de Ruiter
Journal: Behavioral and Brain Sciences (2004)

Any complete theory of speaking must take the dialogical function of language use into account. Pickering & Garrod (P&G) make some progress on this point. However, we question whether their interactive alignment model is the optimal approach. In this commentary, we specifically criticize (1) their notion of alignment being implemented through priming, and (2) their claim that self-monitoring can occur at all levels of linguistic representation.
A MICRO METHOD FOR MEASURING THE CARBON DIOXIDE RELEASE BY SMALL SKIN AREAS
Authors: F. A. J. THIELE, L. H. J. KEMPEN
Journal: British Journal of Dermatology (1972)

Summary.— In search for rapid routine methods for the measurement of carbon dioxide release by human skin, the authors succeeded in improving the infrared analytical method which, when carried out at 4·3 μm, yielded reliable results. Two techniques have been compared, viz. the steady state method (for larger skin areas of about 8 cm2) and the trap technique (which is less dependent on the area to be measured: 1 to 10 cm2). With both techniques micro amounts of carbon dioxide, eliminated by very small areas of the skin and/or the sweat glands, can be determined: 2 to 100 parts/106 of CO2 10 cm‐2 min‐1.
Oxidative Injury to Erythrocytes, Cell Rigidity, and Splenic Hemolysis in Hemodialyzed Uremic Patients
Authors: A. ROSENMUND
Journal: Annals of Internal Medicine (1975)

In 23 hemodialyzed patients the metabolic defect of erythrocytes related to uremia and potentiated by dialysis was studied to establish a possible link with the shortened erythrocyte survival. A highly significant correlation was found between sulfhemoglobin provoked by oxidative stress and erythrocyte rigidity measured by filterability. Impaired filterability also correlated with the degree of splenic sequestration. Both sulfhemoglobin and impaired filterability correlated with the degree of hemolysis. Finally, erythrocyte survival showed a highly significant correlation with the degree of anemia. From osmotic fragility, plasma trapping, erythrocyte ATP and 2,3-diphosphoglycerate (DPG), and serum phosphorus, calcium, and magnesium measurements it seems unlikely that either spheric transformation or sol-gel transformation of the membrane is causing the increased erythrocyte rigidity. In view of the impaired erythrocyte defense capacity against oxidative injury, cell content rigidity as mediated by reduced hemoglobin solubility is a more likely explanation. Our results give a rational basis for a trial of splenectomy in severely anemic hemodialyzed patients.