tbuckley/cabot-search huggingface dataset:
Abstract 2686: Anti-tumor effects of a folate-immunoglobulin conjugate are enhanced by cytokine treatment <i>in vitro</i> and <i>in vivo</i>
Authors: Cristina Jaime-Ramirez, SriVidya Kondadasula, Natalie B. Jones, Aruna Mani, Julie Roda, Volodymyr Karpa, Yanhui Lu, Hong Li, Xiaoli Zhang, David Jarjoura, Robert J. Lee, William E. Carson
Journal: Cancer Research (2011)

Abstract Folate conjugation is a means of selectively targeting therapeutics to folate receptor (FR)-expressing cancer cells. A novel folate-bound immunoglobulin (F-IgG) was tested for its ability to target natural killer (NK) cells to folate-receptor expressing cancer cells in the presence or absence of NK-activating cytokines. FR expression by the KB and HeLa cell lines was confirmed by immunoblot analysis (IB) and flow cytometry. Binding of F-IgG to NK cell Fc receptors led to increased phosphorylation of the epidermal growth factor related kinase (ERK) as measured by IB. Lysis of FR+ KB tumor cells by NK cells was increased 8-fold following treatment with F-IgG as compared to C-IgG (p&amp;lt;0.0001 across E:T ratios from 6.25:1 to 50:1). NK cell lysis of F-IgG- coated KB target cells was significantly enhanced following treatment of NK cells with IL-2, IL-12, IL-15 and IL-21 (all at 10ng/mL). NK cell production of IFN-γ, RANTES and MIP-1α was significantly enhanced by IL-12 in response to F-IgG-coated KB target cells as compared to control-treated cells (p&amp;lt;0.005; IFN-γ-2100 vs. 1000pg/mL, RANTES-800 vs. 150pg/mL, MIP-1α 1800 vs. 500pg/mL, respectively). Studies using the L1210JF murine leukemia model confirmed the anti-tumor activity of F-IgG and the ability of NK-activating cytokines to significantly enhance its effects. NK cell depletion in tumor-bearing mice demonstrated that the anti-tumor effects of IL-12 and F-IgG are dependent on NK cells. These studies indicate that F-IgG induces an immune response by NK cells against FR-positive cancer cell lines and that cytokine treatment has a synergistic effect on this response both in vitro and in vivo. Thus F-IgG has a potential to be used as a therapeutic antibody for the treatment of FR-positive cancers in combination with immune modulatory cytokines. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2686. doi:10.1158/1538-7445.AM2011-2686
Prevalence and molecular characteristics of<i>Staphylococcus aureus</i>isolates colonizing patients with atopic dermatitis and their close contacts in Singapore
Authors: L.S. Chiu, M.S.L. Ho, L.Y. Hsu, M.B.Y. Tang
Journal: British Journal of Dermatology (2009)

Journal Article Prevalence and molecular characteristics of Staphylococcus aureus isolates colonizing patients with atopic dermatitis and their close contacts in Singapore Get access L.S. Chiu, L.S. Chiu National Skin Centre, 1 Mandalay Road, 308205 Singapore Search for other works by this author on: Oxford Academic Google Scholar M.S.L. Ho, M.S.L. Ho National Skin Centre, 1 Mandalay Road, 308205 Singapore Search for other works by this author on: Oxford Academic Google Scholar L.Y. Hsu, L.Y. Hsu Department of Medicine, National University of Singapore, Singapore Search for other works by this author on: Oxford Academic Google Scholar M.B.Y. Tang M.B.Y. Tang National Skin Centre, 1 Mandalay Road, 308205 Singapore Correspondence: Mark Tang. E‐mail: marktang@nsc.gov.sg Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 5, 1 May 2009, Pages 965–971, https://doi.org/10.1111/j.1365-2133.2009.09038.x Published: 01 May 2009
Ventilation???Perfusion Mismatch Resulting From an Aberrant Systemic Arterial Supply to Basal Segmentsof the Right Lung
Authors: A Fuat Yapar, Mehmet Aydin, Dalokay Kilic, Mehmet Reyhan, Fahri Tercan, Aysun Sukan
Journal: Clinical Nuclear Medicine (2005)

A 30-year-old woman was referred for ventilation–perfusion scintigraphy to assess the cause of massive hemoptysis. Scintigraphy showed large segmental ventilation–perfusion mismatched defects in the superior, and lateral and posterior basal segments of the right lower lobe. High-resolution computed tomography was negative for pulmonary embolism. Bronchial angiography demonstrated an arterial malformation between the bronchial and pulmonary arteries.
Silicone implants represent small risk
Authors: J. Roberts
Journal: BMJ (1996)

Silicone breast implants are unlikely to represent a serious danger to health, according to the largest US study to date. The study, published in this week's JAMA (the journal of the American Medical Association), was a retrospective cohort study of nearly 400000 women health professionals. It found that the relative risk of developing any kind of connective tissue disease was 1.24 (95% confidence …
Antibodies to Platelet Factor 4–Heparin After Cardiopulmonary Bypass in Patients Anticoagulated With Unfractionated Heparin or a Low-Molecular-Weight Heparin
Authors: Claire Pouplard, Marc-Antoine May, Sophie Iochmann, Jean Amiral, Anne-Marie Vissac, Michel Marchand, Yves Gruel
Journal: Circulation (1999)

Cardiopulmonary bypass (CPB) induces platelet activation with release of platelet factor 4 (PF4), and patients are exposed to high doses of heparin (H). We investigated whether this contributes to the development of antibodies to H-PF4 and heparin-induced thrombocytopenia (HIT).CPB was performed with unfractionated heparin (UFH) in 328 patients. After surgery, patients received UFH (calcium heparin, 200 IU. kg-1. d-1) (group 1, n=157) or low-molecular-weight heparin (LMWH, Dalteparin, 5000 IU once daily) (group 2, n=171). Eight days after surgery, antibodies to H-PF4 were present in 83 patients (25.3%), 46 in group 1 and 37 in group 2 (P=0.12). Most patients (61%) had IgG1 to H-PF4, but only 8 samples with antibodies induced platelet activation with positive results on serotonin release assay. HIT occurred in 6 patients in group 1, but no thrombocytopenia was observed in subjects receiving LMWH, although 2 had high levels of antibodies with positive serotonin release assay results. When antibodies to H-PF4 were present, mean platelet counts were lower only in patients with FcgammaRIIA R/R131 platelets.These results provide evidence that the development of antibodies to H-PF4 after CPB performed with UFH is not influenced by the postoperative heparin treatment. The antibodies associated with high risk of HIT are mainly IgG1, which is present at high titers in the plasma of patients continuously treated with UFH.
Adenosine-sensitive ventricular tachycardia. Clinical characteristics and response to catheter ablation.
Authors: D J Wilber, J Baerman, B Olshansky, J Kall, D Kopp
Journal: Circulation (1993)

Sustained ventricular tachycardia in the absence of structural heart disease may have diverse mechanisms. Termination of the tachycardia by adenosine suggests triggered automaticity as the etiology in many of these patients. We examined the clinical characteristics, electrophysiological responses, and results of catheter ablation in this patient subgroup.Intravenous adenosine terminated sustained ventricular tachycardia in seven of 14 consecutive patients without evidence of structural heart disease. In each of these patients, the tachycardia had a left bundle branch block, inferior-axis QRS configuration and occurred predominantly during stress or exertion. A morphologically similar sustained tachycardia was induced in six of seven patients during programmed ventricular stimulation, although day-to-day reproducibility was poor. Signal-averaged ECGs were normal in all patients. Imaging with 123I-metaiodobenzylguanidine did not reveal focal abnormalities in any of five patients. A discrete site of origin was identified in the free wall of the pulmonary infundibulum in all patients. Limited application of direct current shocks (two patients) or radiofrequency energy (five patients) resulted in long-term abolition of spontaneous and inducible ventricular tachycardia in all patients.Adenosine-sensitive ventricular tachycardia appears to arise from relatively discrete sites predominantly located in the free wall of the pulmonary infundibulum. The localized nature of this tachycardia renders it amenable to long-term cure by catheter ablation techniques.
Shift From Polyploidizing to Nonpolyploidizing Growth in Carcinogen-Treated Rat Liver1
Authors: G. Saeter, P. E. Schwarze, P. O. Seglen
Journal: JNCI Journal of the National Cancer Institute (1988)

Liver growth patterns in normal and carcinogen-treated young Wistar Kyoto rats were analyzed in terms of absolute hepatocyte numbers and ploidy distributions, calculated from DNA measurements made by flow cytometry and microscope counts of binucleated cells. Polyploidizing growth was observed during normal liver development, dominated by progressive polyploidization and a decrease in the number of diploid cells. Nonpolyploidizing growth was seen during liver regeneration and after treatment with 2-acetylaminofluorene (AAF). This mode of growth was characterized by an increase in all mononucleated ploidy classes in the absence of net polyploidization (no increase in binucleated cells). Additional diploid proliferation was detected after initiation with diethylnitrosamine followed by promotion with AAF. This selectively expanding diploid hepatocyte population, which persisted after AAF withdrawal, could represent the AAF-promoted progeny of diethylnitrosamine-altered cells with constitutive nonpolyploidizing growth properties. [J Natl Cancer Inst 1988; 80: 950–957]
Congenital Syphilis and Necrotizing Funisitis
Authors: Rita M. Fojaco
Journal: JAMA (1989)

During the past 5 years we encountered 16 cases of necrotizing funisitis, a deeply seated inflammatory process within the matrix of the umbilical cord, and established that all of them were associated with maternal and congenital syphilis. During that time necrotizing funisitis was not found to be associated with any other infection. The relationship was unexpected on the basis of current knowledge of the condition, but we found the older medical literature documents syphilis as the virtually specific cause of deep funisitis with angiophlebitis. Necrotizing funisitis has a characteristic macroscopic appearance, the "barberpole" cord, that permits the presumptive diagnosis of congenital syphilis at the time of birth. (<i>JAMA</i>. 1989;261:1788-1790)
Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction
Authors: Toyoharu Oba, Hideo Yasukawa, Masahiko Hoshijima, Ken-ichiro Sasaki, Nobuyoshi Futamata, Daisuke Fukui, Kazutoshi Mawatari, Takanobu Nagata, Sachiko Kyogoku, Hideki Ohshima, Tomoko Minami, Keiichiro Nakamura, Dongchon Kang, Toshitaka Yajima, Kirk U. Knowlton, Tsutomu Imaizumi
Journal: Journal of the American College of Cardiology (2012)
Mammalian Parenting: Biochemical, Neurobiological, and Behavioral Determinants
Authors: David A. Griesemer
Journal: JAMA (1991)

<i>Mammalian Parenting</i>is a fascinating and carefully edited book that draws from many disciplines to describe the current understanding of parenting behavior. Several chapters are superb reviews of basic neuroscience and animal behavior studies that may be of limited clinical interest. There are other chapters, however, that have immediate relevance for physicians. Leon Eisenberg's "Biosocial Context of Parenting" is a beautifully crafted article that should be read by all medical students and physicians. He tells of the "cataclysmic transformation" of today's family structure, which has left the United States with the highest teenage birth rate and the highest teenage abortion rate of any industrialized country. He writes with poignancy about child abuse and infanticide that result from our tolerance of conditions in our society that are associated with high infant mortality. Martin Daly's "Evolution Theory and Parental Motives" and Michael Yogman's "Male Parental Behavior" are thoughtful reviews that will offer
Firearm legislation and the Cullen inquiry
Authors: A M Morris
Journal: BMJ (1996)

Independent medical advisors and a help line would keep doctors out of   the firing line 

On 13 March 1996 Thomas Hamilton walked into the gymnasium at Dunblane Primary School and shot dead 16 children and their teacher. The Secretary of State for Scotland, on behalf of both houses of parliament, asked Lord Cullen to inquire into this tragic incident, and his report is expected at the end of September. It will include recommendations on the control of possession and use of firearms and ammunition, school security, and the vetting and supervision of adults working with children. The Secretary of State for Scotland has made it clear that parliamentary time has been set aside to implement any recommendations.

Under current legislation, people wishing to obtain a certificate to acquire, renew, or alter a firearm or shotgun must fill in a questionnaire. This asks for personal details including a specific question about whether the applicant has ever had epilepsy or any form of mental disorder. All applications must be countersigned by someone who is resident in Britain, who has known the applicant personally for at least two years, …
A Universal Practitioner's License.
Authors: S. B. Lyon
Journal: JAMA (1903)

Los Angeles, Cal., Sept. 4, 1903. <h3>To the Editor:</h3> —InThe Journal, August 29, p. 568, among the unsuccessful candidates in the Tennessee reports of registration, candidate 54, a graduate of the College of Physicians and Surgeons, Baltimore, class of 1876, failed with a per cent. of 70. This fact substantiates the remarks of Dr. T. A. Borton in his article "The Turning Down of the Old Practitioner" published inThe Journal, August 22, p. 505, with the exception that here the other unsuccessful candidates were nearly all recent graduates. Not knowing the questions asked and judging from the markings alone, I have nothing to say against this particular examining board; but I would like to have the following remarks reach those members of the profession who have more influence and power than has the average general practitioner. Something more is needed than a higher curriculum for the elevation of
Viadril: A New Steroid Anaesthetic
Authors: L. H. Lerman
Journal: BMJ (1956)

Very satisfactory 30 75 minutes later patient operation * gr.;dozing.On being scopol-roused says " feels amine fine"1/150 gr.Routine: This surgeon uses adrenaline 0-1 mg. in 60 ml.water as a prostatic capsule haemostatic.The chlorpromazine is here used as a prophylactic against pressor effects.B.P. fell steadily until unreadable, though pule good.Methylamphetamine 30 mg. restored B.P. to 120/70 immediately.
On separating pain from the willingness to report it
Authors: Wolfgang Ellermeier
Journal: Behavioral and Brain Sciences (1997)

Signal-detection methodology may be used to disentangle sensory from judgmental effects when analyzing sex differences in pain. An illustrative example is given by reanalyzing a published category-scaling experiment in terms of detection-theory indices. As a result, the apparent sex difference is recast in terms of a judgmental bias. [berkley]
Refining the definition of hypereosinophilic syndrome
Authors: Hans-Uwe Simon, Marc E. Rothenberg, Bruce S. Bochner, Peter F. Weller, Andrew J. Wardlaw, Michael E. Wechsler, Lanny J. Rosenwasser, Florence Roufosse, Gerald J. Gleich, Amy D. Klion
Journal: Journal of Allergy and Clinical Immunology (2010)
When to Start Antiretroviral Therapy in HIV-Associated Tuberculosis
Authors: M. Estée Török, Jeremy J. Farrar
Journal: New England Journal of Medicine (2011)

Tuberculosis is the most common infectious cause of death in persons infected with the human immunodeficiency virus (HIV). However, many of the basic questions have remained unanswered, such as when to start antiretroviral therapy (ART) in HIV-infected patients who present with tuberculosis. The early initiation of ART, begun either simultaneously with or soon after the start of tuberculosis therapy, may be associated with clinical deterioration related to the immune reconstitution inflammatory syndrome (IRIS), with toxic effects of drugs, drug interactions, and a high pill burden (possibly compromising adherence to therapy). Conversely, a delay in initiating ART may result in AIDS-related . . .
Aerosol Scintigraphy in the Assessment of Therapy for Cystic Fibrosis
Authors: C C KUNI, W E REGELMANN, R P duCRET, R J BOUDREAU, J R BUDD
Journal: Clinical Nuclear Medicine (1992)

Thirteen patients with cystic fibrosis (aged 11 to 32 years) who were hospitalized for exacerbation and who had sputum cultures positive for Pseudomonas organisms were treated initially for 4 days with bronchodilators and physiotherapy followed by the addition of antibiotic (14 days, n = 8) or placebo (14 days, n = 4; 7 days, n = 1). Tc-99m DTPA aerosol scintigraphy was performed on the day before bronchodilators and physiotherapy, on the day before antibiotic or placebo, and on the day after completion of antibiotic or placebo therapy. Scintigrams were evaluated for change in the number of nonventilated segments and change in the number of bronchial deposits of aerosol. Sixty-nine percent of patients showed improvement after bronchodilators and physiotherapy alone. Sixty-two percent showed further improvement after antibiotic or placebo was added; this improvement was independent of whether antibiotic or placebo was administered (P > 0.1). These aerosol scintigraphy results failed to demonstrate that the effectiveness of bronchodilators and physiotherapy is enhanced by antibiotics in the treatment of cystic fibrosis exacerbations.
Response to Letter by Gibson
Authors: Edzard Ernst
Journal: Diabetes Care (2002)

I am obliged to Nathaniel Gibson (1) for his letter in this issue of Diabetes Care because his comments enable me to clarify several points. He is correct in calling part of the evidence I quoted “anecdotal.” This pertains particularly to the cases where providers of complementary and alternative medicine (CAM) have hindered access to essential conventional treatments. Sadly, at the current time, such information can only …
Managing the new NHS: breathing new life into the NHS reforms
Authors: G. Best, D. Knowles, D. Mathew
Journal: BMJ (1994)

The essence of the NHS reforms is that they bring market forces to bear on organisations providing public services, while allowing those organisations more freedom to respond in ways that will improve the efficiency, effectiveness, and appropriateness of their services. The new structural changes to the NHS--a leaner management executive and fewer, slimmer regions--could be used either to strengthen these features of the reforms or frustrate them by allowing ministers and top management to intervene even more at local level and "overmanage" the market. To ensure that the aims of the reforms are not frustrated ministers and the management executive must restrict themselves to laying down clear strategies and then allow purchasers and providers to meet those strategies in their own ways. They also need to ensure that the whole NHS can learn and benefit from local experimentation and devise ways of managing the crises that will inevitably arise; otherwise they might be tempted to become involved in managing the market at too local a level, and the NHS will suffer the worst of both worlds: stifling bureaucracy at the top and parochial self interest locally.
Racial Disparities in Coronary Artery Disease Prevalence
Authors: Paula A. Johnson
Journal: Annals of Internal Medicine (1993)

Letters15 October 1993Racial Disparities in Coronary Artery Disease PrevalencePaula A. Johnson, MD, Thomas H. Lee, MD, and Lee Goldman, MDPaula A. Johnson, MDSearch for more papers by this author, Thomas H. Lee, MDSearch for more papers by this author, and Lee Goldman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-8-199310150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that there may be several reasons why we, like others [1, 2], found less severe coronary artery disease among African-Americans who were referred for cardiac catheterization. A higher rate of diabetes mellitus and hypertension among the African-American population may lead to a higher prevalence of angina due to small-vessel disease and left ventricular hypertrophy. Our database did not include information regarding these risk factors or left ventricular hypertrophy.Data suggest that African-Americans may have less access to primary care services [3] and support our hypothesis that more African-Americans who present to the emergency department may be ...References1. Simmons BE, Castaner A, Campo A, Ferlinz J, Mar M, Cooper R. Coronary artery disease in blacks of lower socioeconomic status: angiographic findings from the cook county Hospital Heart Disease Registry. Am Heart J. 1988; 116:90-7. Google Scholar2. Maynard C, Fisher LD, Passamani ER, Pullum T. Blacks in the coronary artery surgery study: risk factors and coronary artery disease. Circulation. 1986; 74:64-71. Google Scholar3. Blendon RJ, Aiken LH, Freeman HE, Corey CR. Access to medical care for black and white Americans. JAMA. 1989; 261:278-81. Google Scholar4. Johnson PA, Lee TH, Cook EF, Rouan GW, Goldman L. Effect of race on the presentation and management of patients with acute chest pain. Ann Intern Med. 1993; 118:593-601. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1993Volume 119, Issue 8Page: 861KeywordsAnginaCatheterizationDatabasesDiabetes mellitusEmergency departmentHeart diseasesHypertensionLeft ventricular hypertrophyMedical risk factorsStable coronary artery disease Issue Published: 15 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prinzmetal Angina and Cyproheptadine
Authors: Alison D. Schecter
Journal: Annals of Internal Medicine (1995)

Letters15 January 1995Prinzmetal Angina and CyproheptadineAlison D. Schecter, James H. Chesebro, and Valentin FusterAlison D. SchecterSearch for more papers by this author, James H. ChesebroSearch for more papers by this author, and Valentin FusterSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-2-199501150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Ambrus emphasizes that inhibition of platelet aggregation is a potential important pathophysiologic mechanism for serotonergic-receptor blockade in vasospasm. Serotonin is initially released when platelets aggregate and initiate a positive feedback loop by releasing adenosine diphosphate, thromboxane A2, and more serotonin.An early study [1] failed to show a decrease in the number of ischemic episodes in patients with vasospastic angina who were treated with ketanserin, a selective serotonin-receptor (S2) antagonist. Ketanserin was given at concentrations that inhibited in vitro platelet aggregation. The presence of serotonin-receptor families, individual patient characteristics for platelet aggregation, and differing in vivo responses ...REFERENCE1. DeCaterina R, Carpeggiani C, L'Abbate A. A double-blind, placebo-controlled study of ketanserin in patients with Prinzmetal's angina. Circulation. 1984; 69:889-94. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1995Volume 122, Issue 2Page: 155KeywordsAdenosine diphosphateAnginaAttentionPlatelet aggregationPlateletsSerotoninThromboxane Issue Published: 15 January 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...