tbuckley/cabot-search huggingface dataset:
An allergen from <i>Olea europaea</i> pollen (Ole e 7) is associated with plant‐derived food anaphylaxis
Authors: J. F. Florido Lopez, J. Quiralte Enriquez, J. M. Arias de Saavedra Alías, B. Saenz de San Pedro, E. Martin Casañez
Journal: Allergy (2002)

Background Several cross‐reacting proteins have been identified as responsible of the co‐occurrence of pollinosis and plant‐derived food allergy. This association has been mainly described in the birch–apple syndrome but other pollens such as Olea europaea and other fruits may also contain homologous proteins. Objective To evaluate the associations between sensitization to allergens of Olea europaea pollen and confirmed plant‐derived food allergy, in addition to investigate if any pattern of clinical hypersensitivity of food allergy reaction (oral allergy syndrome (OAS) or anaphylaxis) and/or any fresh fruit or nut allergy, are associated to one or several Olea pollen allergen(s). Methods One‐hundred and thirty‐four consecutive patients diagnosed with pollinosis by Olea were studied. Of these patients only 40, reported adverse reaction to plant‐derived food. Twenty‐one (group A) were classified as OAS and 19 (group B) as anaphylaxis. Skin‐tests with six Olea pollen allergens and several groups of fruits, were performed. Double‐blind placebo‐controlled food challenge (DBPCFC), confirmed the diagnostics of food allergy with the exception of patients who suffered previous anaphylactic reaction. Results All patients, showed a positive skin prick test (SPT), against one or more of Olea europaea allergens. Sensitization to Ole e 7, was more frequent ( P = 0.02) in patients from group B. A total of 84 DBPCFC were performed with 44% positive results. Challenge confirmed at least the 50% of positive SPT in any case (peach: 68.42%; pear: 50%; melon: 71.42% and kiwi: 53.84%). In patients from group B, significant association with O. europaea pollen allergens were found between positive SPT to Rosaceae fruits and Ole e 3 ( P = 0.045) and Ole e 7 ( P = 0.03); Cucurbitaceae and Ole e 7 ( P = 0.03) and Actinidiaceae with Ole e 3 ( P = 0.04). Conclusions The results of this study, establish a new spectrum of associations between pollens and plant‐derived foods: sensitization to olive profilin (Ole e 2) is not more frequent in OAS patients. Patients with anaphylactic reaction after eating fruit are also sensitized to Ole e 7, a LTP present in Olea pollen, and suffer pollinic symptoms. Finally a polcalcin (Ole e 3) could be also associated to Olea pollen respiratory and food allergy.
A Thin Green Line
Authors: Scott Waters
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of urea for treatment of water retention in hyponatraemic cirrhosis with ascites resistant to diuretics.
Authors: G Decaux, P Mols, P Cauchi, F Delwiche
Journal: BMJ (1985)

Une observation, cirrhose en decompensation ictero-ascitique. Le traitement intermittent par l'uree (voie orale) a amene une augmentation de la diurese et une perte de poids. En outre l'hyponatremie est corrigee apres le traitement par l'uree malgre la continuation des diuretiques et l'absorption d'eau non limitee
Postinfarction heart failure in rats is associated with upregulation of GLUT-1 and downregulation of genes of fatty acid metabolism
Authors: N Rosenblatt-Velin
Journal: Cardiovascular Research (2001)

Increasing evidence suggests that left ventricular remodeling is associated with a shift from fatty acid to glucose metabolism for energy production. The aim of this study was to determine whether left ventricular remodeling with and without late-onset heart failure after myocardial infarction is associated with regional changes in the expression of regulatory proteins of glucose or fatty acid metabolism.Myocardial infarction was induced in rats by ligation of the left anterior descending coronary artery (LAD). In infarcted and sham-operated hearts the peri-infarction region (5-mm zone surrounding the region at risk), the interventricular septum and the right ventricular free wall were separated for analysis.At 8 and 20 weeks after LAD ligation, the peri-infarction region and the septum exhibited marked re-expression of atrial natriuretic factor [+252+/-37 and +1093+/-279%, respectively, in the septum (P<0.05)] and of alpha-smooth muscle actin [+34+/-10 and +43+/-14%, respectively, in the septum (P<0.05)]. At 8 weeks, when left ventricular hypertrophy was present without signs of heart failure, myocardial mRNA expression of glucose transporters (GLUT-1 and GLUT-4) was not altered, whereas mRNA expression of medium-chain acyl-CoA dehydrogenase (MCAD) was significantly reduced in the peri-infarction region (-25+/-7%; P<0.05). In hearts exhibiting heart failure 20 weeks after infarct-induction there was a change in all three ventricular regions of both mRNA and protein content of GLUT-1 [+72+/-28 and +121+/-15%, respectively, in the peri-infarction region (P<0.05)] and MCAD [-29+/-9 and -56+/-4%, respectively, in the peri-infarction region (P<0.05)].In rats with large myocardial infarction, progression from compensated remodeling to overt heart failure is associated with upregulation of GLUT-1 and downregulation of MCAD in both the peri-infarction region and the septum.
Elderly patients in a general surgical unit: do they block beds?
Authors: J P Wattis
Journal: BMJ (1982)

upper gastrointestinal endoscopy are to enable the examination to be carried out safely and comfortably and to ensure adequate amnesia so that the frequent necessity of repeat endoscopy is never unacceptable to the patient.It seems unnecessary to perform neuroticism inventories, which in any case are not predictive of unfavourable or violent reactions, when safe and simple agents are almost always efficacious.ROGER JONES Andover, Hants JP10 3LI)Elderly patients in a general surgical unit: do they block beds?
End pharma influence on CME, says AMA journal
Authors: Janice Tanne
Journal: BMJ (2006)

The American Medical Association's ethics journal has suggested reducing drug companies' influence on doctors' prescribing habits by stopping the companies paying for continuing medical education (CME; American Medical Association Journal of Ethics 2006;46:357-436).

Such education is required in most US states and by many medical societies. The journal devoted its entire June issue to ways to reduce or manage drug company influence on doctors.

In 2004, more than $2bn (£1.1bn; €1.6bn) was spent on continuing medical education. Medical communications companies and medical schools depend heavily on drug companies to develop educational programmes, say the authors, Dr Adriane Fugh-Berman, an adjunct associate professor and specialist in complementary and alternative medicine at Georgetown …
782. Long-Term Expression of EIAV Lentivectors Pseudotyped with Influenza Virus Spike Glycoproteins after Nasal Delivery to Mice
Authors: Angela M. Giddings, Manij Patel, Lawrence E. Ostrowski, John C. Olsen
Journal: Molecular Therapy (2006)

There are multiple challenges for achieving long-term expression by lentivirus-mediated gene transfer. Potential problems include down-regulation or destruction of transduced cells due to an immune response or shut down of gene expression due to silencing. Cell- specific promoters may help alleviate some of these potential problems by restricting expression to a smaller subset of cells, or by promoting regulated expression in terminally differentiated cells. The purpose of this study was to determine how constructs containing various airway-specific promoters behave in an in vivo mouse model for airway gene transfer. Specifically, we were interested in the duration of expression following nasal delivery and whether there was an immune response to lentivectors based upon equine infectious anemia virus (EIAV). SIN vectors were constructed containing gfp, luciferase, or lacZ reporter genes driven by the human FOXJ1 promoter or the long terminal repeats (LTR) of Jaagsiekte Sheep Retrovirus (JSRV) or Enzootic Nasal Tumor Virus (ENTV). Control vectors contained a composite CMV/beta-actin (CB) promoter. Adult outbred mice were inoculated intranasally with luciferase vectors pseudotyped with influenza hemagglutinin (HA). We utilized a cooled-coupled device (CCD) camera to image the mice starting at week 2 post-infection. At week 12, some of the mice were infected with a second HA-pseudotyped vector that expressed GFP or beta-galactosidase. Blood was drawn from these mice prior to infection and at 1 and 14 weeks post-infection to determine if there was a neutralizing antibody response to HA pseudotyped vectors or to control vectors pseudotyped with VSV- G. Stable luciferase expression was observed through week 22 in mice receiving the FOXJ1-luciferase vector. Mice receiving the ENTV, JSRV and CB promoter constructs showed more variation in levels of expression. Luciferase expression was still observed in most of the mice at week 14 when all but three of the FOXJ1-luciferase mice were sacrificed. Analysis of heat-inactivated serum demonstrated that neutralizing antibodies directed against the HA pseudotyped vector were produced in mice that received two doses of at least 100,000 infectious vector particles. Neutralizing activity was not observed after a single dose of the vector. Experiments are in progress to determine vector expression levels following re-administration to mice that have developed neutralizing serum antibodies. In conclusion, we observed expression from the EIAV FOXJ1-luciferase vector for at least 22 weeks following a single administration to the nose. Stability of luciferase expression was dependent upon the promoter used to drive transcription. Expression from the FOXJ1 promoter showed the most consistency between mice and was more stable over time than the other promoters that were tested.
The management of teenage pregnancy
Authors: F. P. McCarthy, U. O'Brien, L. C. Kenny
Journal: BMJ (2014)

<h3>Summary</h3> All eutherian mammals show chromosomal sex determination with contrasting sex chromosome dosages (SCDs) between males (XY) and females (XX). Studies in transgenic mice and humans with sex chromosome trisomy (SCT) have revealed direct SCD effects on regional mammalian brain anatomy, but we lack a formal test for cross-species conservation of these effects. Here, we develop a harmonized framework for comparative structural neuroimaging and apply this to systematically profile SCD effects on regional brain anatomy in both humans and mice by contrasting groups with SCT (XXY and XYY) vs. XY controls. We show that total brain size is substantially altered by SCT in humans (significantly decreased by XXY and increased by XYY), but not in mice. Controlling for global effects reveals robust and spatially convergent effects of XXY and XYY on regional brain volume in humans, but not mice. However, mice do show subtle effects of XXY and XYY on regional volume, although there is not a general spatial convergence in these effects within mice or between species. Notwithstanding this general lack of conservation in SCT effects, we detect several brain regions that show overlapping effects of XXY and XYY both within and between species (cerebellum, parietal, and orbitofrontal cortex) - thereby nominating high priority targets for future translational dissection of SCD effects on the mammalian brain. Our study introduces a generalizable framework for comparative neuroimaging in humans and mice and applies this to achieve a cross-species comparison of SCD effects on the mammalian brain through the lens of SCT. <h3>Highlights</h3> Parallel structural neuroimaging in humans and mice with sex chromosome trisomies Divergent X- and Y-chromosome effects on human brain size, but convergent effects on regional anatomy Muted impact of additional X or Y on mouse brain, but subtle regional effects evident Evidence for conserved cross-species impact of X and Y on fronto-parietal cortices and cerebellum
DIGITAL FIBROUS SWELLINGS IN CHILDREN
Authors: A. W. McKENZIE, F. L. F. INNES, J. M. RACK, A. S. BREATHNACH, M. GROSS
Journal: British Journal of Dermatology (1970)

Journal Article DIGITAL FIBROUS SWELLINGS IN CHILDREN Get access A. W. McKENZIE, A. W. McKENZIE Norfolk and Norwich Hospital Search for other works by this author on: Oxford Academic Google Scholar F. L. F. INNES, F. L. F. INNES Norfolk and Norwich Hospital Search for other works by this author on: Oxford Academic Google Scholar J. M. RACK, J. M. RACK Norfolk and Norwich Hospital Search for other works by this author on: Oxford Academic Google Scholar A. S. BREATHNACH, A. S. BREATHNACH Department of Anatomy, St Mary's Hospital Medical School, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar M. GROSS M. GROSS Department of Anatomy, St Mary's Hospital Medical School, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 4, 1 October 1970, Pages 446–458, https://doi.org/10.1111/j.1365-2133.1970.tb15077.x Published: 01 October 1970 Article history Accepted: 26 May 1970 Published: 01 October 1970
Narrative based medicine: A narrative approach to mental health in general practice
Authors: J. Launer
Journal: BMJ (1999)

This is the second in a series of five articles on narrative based medicine

There is a tension between the complex narrative that a patient brings into the consulting room and a doctor's understanding of what is really going on as formulated in a diagnosis or an idea about pathology. Which is a “truer” account of reality: the patient's or the doctor's? Can both be true? If so, how?

   ![][1] 

These questions are particularly relevant in mental health care for a number of reasons. Firstly, sociology and ethnography have identified psychiatry alone among the medical specialties as peculiarly culture bound. 1 2 Secondly, psychiatry lies in an uncomfortable no man's land between conventional medical science and the search for meaning which may extend into political and religious domains.3 Thirdly, mental health professionals often use confusing and contradictory language to describe their observations. When compared with the babel of explanatory models which often seem to disqualify each other or which may simply be a way of asserting the therapist's power, the patient's own story may gain in authority and seem saner than the professional's version.4 Finally, psychiatry is the only area of specialist medicine in which talking and listening are explicitly understood to be therapeutic.5

#### Summary points

In a book on the use of narrative in family therapy, Papadopoulos and …

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Laboratory diagnosis of gastrointestinal bleeding
Authors: L. Steingold, A. A. Roberts
Journal: Gut (1961)

The value of four tests to detect occult alimentary blood loss has been compared in normal subjects, in patients with and without alimentary disease, and in patients with congestive heart failure, and the sensitivities of these tests have been compared using suspensions of blood alone and blood in faeces. The Occultest proved almost as sensitive as did the benzidine test in the detection of faecal blood loss, and, if combined with a spectroscopic test for protoporphyrin, minimizes the number of ;false' positive results that are reported. Such false positive results will inevitably occur but are reduced by dietary restriction before the test is made.
A major role of TGF-β1 in the homing capacities of murine hematopoietic stem cell/progenitors
Authors: Claude Capron, Catherine Lacout, Yann Lécluse, Valérie Jalbert, Hédia Chagraoui, Sabine Charrier, Anne Galy, Annelise Bennaceur-Griscelli, Elisabeth Cramer-Bordé, William Vainchenker
Journal: Blood (2010)
Pharmacotherapy in Chronic Kidney Disease Patients Presenting With Acute Coronary Syndrome
Authors: Jeffrey B. Washam, Charles A. Herzog, Amber L. Beitelshees, Mauricio G. Cohen, Timothy D. Henry, Navin K. Kapur, Jessica L. Mega, Venu Menon, Robert L. Page, L. Kristin Newby
Journal: Circulation (2015)
Pattern analysis of human cutaneous mast cell populations by total body surface mapping
Authors: A. Weber, J. Knop, M. Maurer
Journal: British Journal of Dermatology (2003)

Mast cells (MCs), critical effector cells in allergic inflammation and innate immunity to bacteria, are located in large numbers in tissues that interface the external environment, including the skin. However, little is known about the distribution and numbers of human skin MCs.To assess the influence of age, sex and skin region on size and spatial distribution of MC populations in normal human skin.Biopsies of healthy skin were obtained from 150 male and female individuals (age range 10-86 years). MCs were quantified and mapped planimetrically by histomorphometry in 15 anatomical sites (abdomen, thorax, lower and upper back, lower and upper arm, lower and upper leg, foot, hand, chin, nose, cheek, forehead, back of head).No differences in skin MC numbers or distribution were found when comparing skin obtained from male or female and from young or old individuals. At all skin sites, regardless of age or sex, MC numbers were highest in the most superficial skin layers where up to 10-fold more MCs were found as compared with the subcutis, which consistently contained the lowest numbers of MCs. Interestingly, MC numbers were highest at peripheral skin sites (maximum: chin and nose) and lowest at central skin sites (minimum: abdomen). Thus, healthy human skin exhibits a proximal/distal and a central/peripheral MC gradient and 'skin MC numbers' may vary by a factor of more than 20, depending on the skin layer and skin site analysed.These findings support the recently identified role of MCs in the elicitation of protective immune responses against infectious microorganisms. One possible explanation for these unexpected findings is that skin site/layer-specific factors (e.g. the density of nerves or vessels, exposure to ultraviolet irradiation, frequency of minimal trauma) are involved in the regulation of skin MC numbers and distribution.
Improved Survival After Out-of-Hospital Cardiac Arrest Is Associated With an Increase in Proportion of Emergency Crew–Witnessed Cases and Bystander Cardiopulmonary Resuscitation
Authors: Jacob Hollenberg, Johan Herlitz, Jonny Lindqvist, Gabriel Riva, Katarina Bohm, Mårten Rosenqvist, Leif Svensson
Journal: Circulation (2008)

Out-of-hospital cardiac arrest (OHCA) is a major public health problem. We sought to describe changes in 1-month survival after OHCA in patients given cardiopulmonary resuscitation (CPR) during the last 14 years in Sweden.All patients experiencing OHCA in whom CPR was attempted between 1992 and 2005 and who were reported to the Swedish Cardiac Arrest Register were included in the study. In all, 38,646 patients were included in this survey. The proportion of patients who were admitted alive to a hospital increased from 15.3% in 1992 to 21.7% in 2005 (P for trend <0.0001). The corresponding values for patients being alive after 1 month were 4.8% and 7.3%, respectively (P for trend <0.0001). The increase in 1-month survival was particularly evident among patients found with a shockable rhythm (increase from 12.7% in 1992 to 22.3% in 2005; P for trend <0.0001). The corresponding figures for patients found with a nonshockable rhythm were 1.2% in 1992 and 2.3% in 2005 (P for trend=0.044). Factors that potentially contributed to the improved survival rate were an increase in emergency medical crew-witnessed cases from 9% in 1992 to 15% in 2005 (P for trend <0.0001) and, to a lesser degree, an increase in bystander CPR from 31% in 1992 to 50% in 2005 (P for trend <0.0001). After adjustment for potential risk factors, the increase in survival remained significant.We found a significant increase in survival after OHCA in Sweden over the last 14 years. The increase was particularly marked among patients found with a shockable rhythm and was associated with an increase in the proportion of crew-witnessed cases and, to a lesser degree, an increase in the performance of bystander CPR.
The Lurking Sperm: Vasectomy Failures-Reply
Authors: Stanwood S. Schmidt
Journal: JAMA (1988)

<h3>In Reply. —</h3> I appreciate the letters in response to my editorial on vasectomy. Scientific progress is made by discussion and the exchange of knowledge. Dr Alderman's results have provided us with a valuable yardstick with which to measure the most popular method of vasectomy, and he has done us a favor. The fact that I feel that there is a better way does not diminish the personal regard that I have for this fine man. I cannot say why others have not published their experiences with the fulguration, fascial interposition method, but I have many friends who have had excellent results with it. Any failures could only result from improperly carrying out the operation, such as incompletely covering the vas end with fascia. Dr Barnhouse, in leaving the testicular end of the vas untouched, brings up a point that I had avoided when I wrote that "at least one
Department without daylight
Authors: S. M Hewitt
Journal: BMJ (1993)

corrected for wrong addresses will improve the apparent efficiency of screening while failing to locate those who are being missed.Other methods of improving lists of patients' addresses that we have used in our research studies include periodic mailings to patients, recording an alternative contact address, using Post Office returns (which identified 40% of inaccurate addresses in one mailing in our experience), examining general practices' manual and com- puterised records, and using local telephone books.The relative cost effectiveness of these methods depends on the extent of automation that can be achieved.Direct linkage of computerised records of practices and family health services authorities, with a formal protocol for checking and updating a practice's address records at each contact with a patient, probably holds out the best hope of achieving a register with minimal errors in addresses to optimise uptake of screening.The technology to achieve this has already been adopted in other European countries.
The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection
Authors: Shinji Kakimoto, Tsutomu Hamada, Yuuki Komatsu, Masahiro Takagi, Toshizumi Tanabe, Hideki Azuma, Seiji Shinkai, Takeshi Nagasaki
Journal: Biomaterials (2008)
Behaviour of the bovine pericardium used in cardiac bioprostheses when subjected to a real fatigue assay
Authors: A. Carrera San Martin, J.M. Garci´a Paez, E. Jorge-Herrero, I. Milla´n, R. Navidad, J.V. Garci´a Sestafe, I. Candela, J.L. Castillo-Olivares
Journal: Biomaterials (1993)