Pulmonary Hypertension and Liver Disease
Authors: Richard H. Moseley, Peter Traber, Jorge Gumucio
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 October 1988Pulmonary Hypertension and Liver DiseaseRichard H. Moseley, MD, Peter Traber, MD, Jorge Gumucio, MDRichard H. Moseley, MDSearch for more papers by this author, Peter Traber, MDSearch for more papers by this author, Jorge Gumucio, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-8-679_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We read with interest the article by Goldsmith and coworkers (1) on primary pulmonary hypertension in five patients with classic hemophilia. Pulmonary hypertension is a recognized, although uncommon, complication of chronic liver disease (2, 3). The rarer association of pulmonary hypertension with extrahepatic portal vein obstruction in the absence of intrinsic liver disease (4) suggests that the common mechanism for the pulmonary vascular disease is portasystemic shunting of yet-to-be identified toxic substances. We, therefore, question whether the presence of intrinsic liver disease or portal hypertension, or both, was effectively excluded in their patients. In asymptomatic hemophilic patients,...References1. GoldsmithBailyBrettler GRD Primary pulmonary hypertension in patients with classic hemophilia. Ann Intern Med. 1988;108:797-9. LinkGoogle Scholar2. LebrecCapronDhumeauxBenhamou DJDJ. Pulmonary hypertension complicating portal hypertension. Am Rev Resp Dis. 1979;120:849-56. MedlineGoogle Scholar3. McDonnellToyeHutchins PPG. Primary pulmonary hypertension and cirrhosis: are they related? Am Rev Respir Dis. 1983;127:437-41. CrossrefMedlineGoogle Scholar4. CohenRubinTaylorCuthbert MLWJ. Primary pulmonary hypertension: an unusual case associated with extrahepatic portal hypertension. Hepatology. 1983;3:588-92. CrossrefMedlineGoogle Scholar5. SperoLewisVan ThielHasibaRabin JJDUB. Asymptomatic structural liver disease in hemophilia. N Engl J Med. 1978;298:1373-8. CrossrefMedlineGoogle Scholar1. AlexanderLandwehr BG. Studies of hemophilia: I. The control of hemophilia by repeated infusion of normal human plasma. JAMA. 1948;138:174-9. CrossrefMedlineGoogle Scholar2. LesesneMorganBlattWebsterRoberts HJPWH. Liver biopsy in hemophilia A. Ann Intern Med. 1977;86:703-7. LinkGoogle Scholar3. Forbes C. Clinical aspects of the hemophilias and their treatment. In: Ratnoff OD, Forbes CH, eds. Disorders of Hemostasis. Orlando: Grune and Stratton; 1984:200-1. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center University of Michigan Medical Center Ann Arbor, MI 48105 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1988Volume 109, Issue 8Page: 679-679KeywordsChronic liver diseaseHemophilia ALiver diseasesPortal hypertensionPortal veinsPulmonary hypertensionPulmonary vascular diseases Issue Published: 15 October 1988 PDF DownloadLoading ...