tbuckley/cabot-search huggingface dataset:
OBSERVATIONS ON DOUBLE ALBUMIN: A GENETICALLY TRANSMITTED SERUM PROTEIN ANOMALY *†
Authors: David P. Earle, Martin P. Hutt, Karl Schmid, David Gitlin
Journal: Journal of Clinical Investigation (1959)

Knedel (3,4) has published observations on "double albumin" noted on electrophoresis of the serum proteins of eight members of two families in Germany.The anomaly appeared in three generations of one of the families.Immunochemical studies demonstrated that botlh fractions in the albumin region, designated A1 and A, by Knedel, were indeed albumin.The present paper is a report of a similar anomaly in 25 of 43 members of a family of Nor- wegian descent living in Illinois.A number of immunoand physicochemical observations on the anomalous protein are described.In our preliminary report (1) we designated the two fractions A and B, being unaware at the time of Knedel's prior work and designations of fractions A1 and A2.Despite Knedel's priority, we have decided to retain our terminology of al- bumin A and albumin B. Albumin A corresponds to Knedel's fraction A1 and probably is normal albumin, as will be shown.Albumin B corre- sponds to Knedel's fraction A., and is an anoma- lous albumin.No evidence exists that the anoma- lous albumin fractions in the several unrelated families are chemically identical.Paralbumin, therefore, might be a more acceptable general designation for the anomalous protein.OBSERVATIONS 1. Discovery of anomaly, clintical and genietic data.A 22 year old white male complained of pain in the right costo-vertebral angle area.The urine contained 2 plus * Some of these data were presented at the annual meet- ing of the
A Guinea Pig's View of Research
Authors: Michael J. Bernstein
Journal: JAMA (1982)

ABSTRACT The scientific method has created for biologists the need for organisms that possess specific characteristics, that facilitate experimental studies. Discovery of such creatures relies heavily on serendipity, and this may explain the peculiar array of living things now found in the laboratory. For example, a relatively insignificant insect like the fruit fly has been elevated to celebrity status by geneticists who exploit the short life-cycle and easily discernible phenotypes of Drosophila melanogaster. Mammalian experiments have always favored the use of rodents, which provide an easily manipulated biologic system remarkably similar to our own. Perhaps in this capacity they have repaid their debt to human society incurred as vectors in the spread of disease. One rodent worthy of mention is Cavia porcellus, the guinea pig. The popularity of this denizen of the laboratory has fostered the use of its name as a metaphor for virtually any experimental animal.Not least on
Application of Percutaneous Transluminal Coronary Angioplasty to Coronary Arterial Stenosis in Kawasaki Disease
Authors: Toshihiro Ino, Katsumi Akimoto, Mataichi Ohkubo, Kei Nishimoto, Keijiro Yabuta, Junji Takaya, Hiroshi Yamaguchi
Journal: Circulation (1996)

Background Percutaneous transluminal coronary angioplasty (PTCA) has rarely been performed on patients with coronary lesions that result from Kawasaki disease. In this study, we retrospectively evaluated the effectiveness of PTCA in five patients with coronary arterial stenosis that resulted from Kawasaki disease and reviewed previous reports for possible indicators of PTCA effectiveness. Methods and Results Five patients, ranging in age from 2 to 16 years (median, 8 years), underwent conventional PTCA for localized stenosis. The lesion targeted for PTCA was located in the middle right coronary artery of three patients and in the left anterior descending artery in two patients. In four of the five patients, PTCA was angiographically effective, with stenosis rates improving from 84±10% to 33±11% ( P &lt;.05). When the previously reported cases of six similar patients were taken into consideration, the only predictor of successful PTCA seemed to be the time elapsed between the onset of Kawasaki disease and performance of this procedure. Conclusions In cases in which patients show significant localized stenosis as a result of Kawasaki disease, PTCA should be attempted within 6 to 8 years of the onset of the disease. Additionally, intravascular ultrasound imaging was found to be a useful tool for evaluating internal morphology before and after PTCA. In older patients with coronary calcification, other alternatives to PTCA, such as the use of a rotablator or an atherectomy catheter, should be considered.
Difference between Evolutionarily Effective and Germ line Mutation Rate Due to Stochastically Varying Haplogroup Size
Authors: L. A. Zhivotovsky, P. A. Underhill, M. W. Feldman
Journal: Molecular Biology and Evolution (2006)

Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3–4 times smaller.
Two Cases of Congenital Absence of One Kidney in Same Family
Authors: J. P. Bound
Journal: BMJ (1943)

tion showed a normal pudendum, except that the vagina could not be found.On rectal examination the ovaries could be felt, but the uterus was not palpated.Intravenous pyelography showed that the kidneys were normal in position and function.The patient was extremely anxious for operation and willing to accept its limitations. Report of OperationThe operation was performed in July, 1942.The patient was placed in the lithotomy position and the recto-vesical space dissected up to the peritoneum.A long tissue forceps was put in the cavity and the Trendelenburg position adopted for the second stage of the operation.The abdomen was next opened by a right paramedian incision; the ovaries, tubes,
Medical Ethics' Assault Upon Medical Values
Authors: Colleen D. Clements
Journal: JAMA (1983)

The authors argue that current theories of medical ethics, based on a philosophical patient-oriented autonomy model, have subverted values that are essential to medicine. They analyze the concept of autonomy, then outline attempts to apply the autonomy ethic to medicine by establishing its primacy over principles such as paternalism or patient good. Critics of autonomy ethics have proposed alternatives that are equally at odds with traditional medical values. After tracing the decline of traditional medical norms, Clements and Sider call for a new clinical ethic concerned with the adaptation, function, and best interest of the patient.
Pancreatic endoscopic ultrasound-assisted rendezvous procedure to facilitate drainage of nondilated pancreatic ducts
Authors: G. Papachristou, F. Gleeson, B. Petersen, M. Levy
Journal: Endoscopy (2007)

The use of therapeutic transmural endoscopic ultrasound-assisted rendezvous procedures has been reported previously in patients with obstructive chronic pancreatitis [1] [2] [3] [4] [5]. However, there have been no reports describing the use of this technique in patients with normal pancreatic duct dimensions.
Bismuth 213–labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts
Authors: Brenda M. Sandmaier, Wolfgang A. Bethge, D. Scott Wilbur, Donald K. Hamlin, Erlinda B. Santos, Martin W. Brechbiel, Darrell R. Fisher, Rainer Storb
Journal: Blood (2002)
Body potassium content and capacity of elderly individuals with and without cardiac failure
Authors: M. LYE
Journal: Cardiovascular Research (1982)

Journal Article Body potassium content and capacity of elderly individuals with and without cardiac failure Get access MICHAEL LYE MICHAEL LYE * From the Department of Geriatric Medicine, University of Manchester *Address: University Hospital of South Manchester, Nell Lane, Manchester M20 8LR. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 16, Issue 1, January 1982, Pages 22–25, https://doi.org/10.1093/cvr/16.1.22 Published: 01 January 1982
Sclerotherapy of Oesophageal Varices after Variceal Haemorrhage
Authors: Ph. Van Hootegem, P. Rutgeerts, J. Fevery, L Broeckaert, J. de Groote, G. Vantrappen
Journal: Endoscopy (1984)

Fifty-six patients with recent variceal haemorrhage were studied in a trial of repeated injection sclerotherapy through the flexible oesophagoscope, with a mean follow-up of 15.2 months (1-39). Twenty-five patients (45%) did not suffer further bleedings. The risk of bleeding per patient-month of follow-up decreased significantly (p less than 0.05) after starting therapy, in all groups of cirrhosis, classified according to Child's criteria. Mortality during the study period was 39% (19.6% due to recurrence of variceal bleeding). The main complications of the procedure were the development of oesophageal wall ulcerations and oesophageal stricture.
Long-term circadian effects of salmeterol in asthmatic children treated with inhaled corticosteroids.
Authors: G G Meijer, D S Postma, P G Mulder, W M van Aalderen
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The present study was set up to investigate whether salmeterol in children with asthma already treated with inhaled corticosteroids (ICS) leads to a sustained bronchodilator effect and decreased bronchial responsiveness, both during the day and night. Furthermore, we investigated whether cessation of salmeterol leads to a rebound increase in bronchial responsiveness. Forty children with asthma (aged 7-15 yrs) using ICS participated in a randomized, double-blind, parallel study. They received either twice daily 50 micrograms salmeterol or placebo. FEV1 and provocative concentration of methacholine that caused a 20% fall in FEV1 (PC20) were measured at 4:00 P.M. and 4:00 A.M. at baseline and after 16 wk. The same measurements were performed at 4:00 P.M. at 8 h after the first dose, and after 1 and 8 wk. After cessation of the study drug, FEV1 and PC20 were measured at 12 and 20 h and after 1 wk. Overall mean FEV1 from 1 to 16 wk of treatment was significantly higher in the salmeterol group than in the placebo group (difference, 4.9 +/- 2.0%, p = 0.01). Evolution in time of FEV1 did not differ significantly between the two groups (p = 0.09). Overall mean PC20 from 1 to 16 wk of treatment was not significantly higher with salmeterol than with placebo (difference, 0.7 +/- 0.4 doubling dose [DD] p = 0.07); evolution in time of PC20 did not differ significantly between the two groups (p = 0.58).(ABSTRACT TRUNCATED AT 250 WORDS)
The Art of Self-Mutilation
Authors: Kenneth M. Halprin
Journal: JAMA (1966)

In this form of self-induced lesions of the skin, patients have the unshakable conviction that they are infested with some insect of microscopic size. Excoriations and scars attest to the vigilance with which the pests have been searched for and destroyed with fingernails, knives, and caustics. A physician is consulted not to heal the wounds but to better identify and combat the invading parasites. Insignificant defects in normal skin are pointed out as harboring the parasite. Before the observing eye of the physician, the patient will demonstrate exactly how the search for and destruction of the parasite is accomplished. Fear of the parasite is surprisingly not part of the pattern, but rather it consists of an obsessional preoccupation accompanied by no little satisfaction when a likely bit of skin has been removed. As with "neurotic excoriations," lesions are predominantly in readily accessible areas such as the outer aspects of the
Detection of Coxsackie B Virus Myocarditis on Tc-99m PYP Myocardial Imaging
Authors: CHIA-HUNG KAO, SHYH-JEN WANG, SHIH-HWA YEH
Journal: Clinical Nuclear Medicine (1992)

A 40-year-old woman was admitted because of an onset of acute anterior chest pain and palpitation with lowgrade fever. Coxsackie B virus myocarditis was diagnosed. The Tc-99m HMPAO labeled WBC heart scan, Ga-67 citrate heart scan, and Tc-99m PYP heart scan were arranged to detect the existence and severity of myocarditis.
FDG PET/CT Demonstrated Rapid Progression of Mediastinal Lymphadenopathy in Sarcoidosis
Authors: Cheng-Yi Cheng, Wen-Sheng Huang, Daniel H. Shen, Yu-Ming Fan, Hsian-Her Hsu, Shiou-Chi Cherng, Shih-Chun Lee
Journal: Clinical Nuclear Medicine (2007)

Mediastinal lymphadenopathy is usually a sign of serious underlying disease. A patient who had nodular patchy opacity of the right hilum from a routine screening chest radiograph was referred for the whole-body PET/CT scan with FDG. The initial PET/CT scan demonstrated mediastinal lymphadenopathy and a 2-month follow-up PET/CT revealed the progression of lymphadenopathy with several newly developed FDG-avid nodes. Biopsy demonstrated chronic noncaseating granulomatous process, which was consistent with sarcoidosis. This report may suggest the possibility that rapid progression in size and FDG uptake of mediastinal nodes could be sarcoidosis and not malignancy.
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
Authors: Alfonso Quintás-Cardama, Kris Vaddi, Phillip Liu, Taghi Manshouri, Jun Li, Peggy A. Scherle, Eian Caulder, Xiaoming Wen, Yanlong Li, Paul Waeltz, Mark Rupar, Timothy Burn, Yvonne Lo, Jennifer Kelley, Maryanne Covington, Stacey Shepard, James D. Rodgers, Patrick Haley, Hagop Kantarjian, Jordan S. Fridman, Srdan Verstovsek
Journal: Blood (2010)
Relationship between plasma concentration and dose of digoxin in patients with and without renal impairment.
Authors: R D Okada, W D Hager, P E Graves, M Mayersohn, D G Perrier, F I Marcus
Journal: Circulation (1978)

The purpose of this study was to determine if there is a linear relationship between oral doses of digoxin and various measurements of steady-state digoxin plasma concentration and urinary excretion in patients with wide range of renal function. Ten patients (mean age 58 years) with creatinine clearances greater than 50 ml/min/1.73 m2 BSA (mean creatinine clearance 80 ml/min/1.73 m2 BSA) and nine patients mean age 61 years) with creatinine clearances less than 50 ml/min/1.73 m2 BSA (mean creatinine clearance 20 ml/min/1.73 m2 BSA) were given digoxin tablets orally at two or three different dose levels (dose range 0.0313--0.5 mg/day). After a dosing period equal to at least five half-lives, three to four consecutive daily digoxin plasma concentrations were determined. Plasma concentrations and urinary digoxin excretion were measured during one 24-hour dosing interval at each dose level. Digoxin plasma and urine concentrations were determined in triplicate using radioimmunoassay. Individual patient plots provided evidence of linearity for: digoxin 24-hour steady-state plasma concentration vs dose; digoxin 24-hour cumulative urinary excretion versus dose; and area under the digoxin plasma concentration-time curve during a 24-hour dosing interval vs dose. Absolute values for these various parameters indicated substantial interpatient variation probably due to patient differences in both digoxin absorption and digoxin total body clearance. These results indicate that there is a linear relationship between digoxin plasma concentration and dose in patients with normal and decreased renal function. This linearity is support for dose-independent pharmacokinetics of digoxin in man. We conclude from these data that a change in digoxin dose should result in a proportional change in digoxin plasma concentration over the dose range examined.
TCT-379 A Comparison of the Success Rates and Long-Term Outcomes after percutaneous coronary intervention Between In-stent Restenosis and de novo Chronic Total Occlusion lesions
Authors: Seung-Young Roh, Hyung Joon Joo, Jae Hyoung Park, Chul-Min Ahn, Soon Jun Hong, Cheol Woong Yu, Do-Sun Lim
Journal: Journal of the American College of Cardiology (2013)
Nonsustained Ventricular Tachycardia in Ambulatory Patients: Characteristics and Association with Sudden Cardiac Death
Authors: WILLIAM P. FOLLANSBEE
Journal: Annals of Internal Medicine (1980)

Thirty-seven patients with nonsustained ventricular tachycardia (greater than or equal to triplets) were identified retrospectively from a population of 518 consecutive patients referred for 24-hour Holter monitoring and studied to determine the prognostic significance of this finding. Ten of these 37 patients suffered sudden cardiac death during a mean follow-up of 19 +/- 5 months. Nine of 19 patients with a diagnosis of congestive cardiomyopathy or history of congestive heart failure died suddently compared to only one of the other 18 patients. No other patient data were predictive of sudden death. Remarkably, no characterisitc of the ventricular tachycardia including beats per episode, episodes per day, rate, prematurity index (RR1/QT) of the initiating beat, or the occurrence of associated arrhythmias was important prognostically. Thus, patients with congestive cardiomyopathy or congestive heart failure and nonsustained paroxysmal ventricular tachycardia are at a high risk for sudden death and are ideal candidates for prophylactic interventions.
Diagnostic accuracy of clathrin heavy chain staining in a marker panel for the diagnosis of small hepatocellular carcinoma
Authors: Luca Di Tommaso, Annarita Destro, Valentina Fabbris, Gaia Spagnuolo, Anna Laura Fracanzani, Silvia Fargion, Marco Maggioni, Carlo Patriarca, Roberto Maria Macchi, Michela Quagliuolo, Mauro Borzio, Massimo Iavarone, Angelo Sangiovanni, Massimo Colombo, Massimo Roncalli
Journal: Hepatology (2011)

Abstract The American Association for the Study of Liver Diseases guidelines recommend the use of all available markers for improving the accuracy of the diagnosis of small hepatocellular carcinoma (HCC). To determine whether clathrin heavy chain (CHC), a novel HCC marker, is effective in combination with glypican 3 (GPC3), heat shock protein 70, and glutamine synthetase, we compared the performances of a three-marker panel (without CHC) and a four-marker panel (with CHC) in a series of small HCCs (≤2 cm) and nonsmall HCCs by core biopsy with a 20- to 21-gauge needle. The series included 39 nonsmall HCCs and 47 small HCCs (86 in all); the latter showed a well-differentiated histology [small grade 1 (G1)] in 30 cases (63.8%). The panel specificity was analyzed with the adjacent/extranodular cirrhotic liver (n = 30) and low-grade (n = 15) and high-grade dysplastic nodules (n = 16) as a control group. Absolute specificity (100%) for HCC was obtained only when at least two of the markers were positive (which two markers were positive did not matter). The addition of CHC to the panel increased the diagnostic accuracy for small HCCs (from 76.9% to 84.3%), and there was an important gain in sensitivity (from 46.8% to 63.8%). The four-marker panel had lower rates of accuracy (67.4%) and sensitivity (50%) for small G1 HCCs versus nonsmall G1 HCCs (93.9% and 88.2%, respectively). In seven cases (including six small G1 HCCs), there was no staining with any of the markers. Cirrhotic control livers were stained for CHC in four cases (13.3%) and for GPC3 in one case (3.3%). Conclusion: The addition of CHC to the panel supports the diagnosis of small HCCs in challenging nodules on thin core biopsy samples. Small G1 HCCs include a group of earlier tumors characterized by a more silent phenotype and the progressive acquisition of the markers under study. The search for additional markers for early HCC diagnosis is warranted. (Hepatology 2011;)
Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans.
Authors: B J O'Connor, S Uden, T J Carty, J D Eskra, P J Barnes, K F Chung
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Inhaled PAF provokes bronchoconstriction, causes peripheral blood neutropenia with rebound neutrophilia, and generates urinary production of the bronchoconstrictor eicosanoids, thromboxane (TX)A2, and the cysteinyl leukotrienes. We examined the effects of an oral PAF antagonist UK,74505 on each of these responses to a single 36 micrograms dose of inhaled PAF. In a double-blind randomized placebo-controlled crossover study, 12 normal male subjects inhaled PAF on two consecutive days, 3 and 24 h after intake of two doses of UK,74505 25 mg and 100 mg, or matched placebo (P). After P, inhalation of PAF provoked bronchoconstriction, measured at regular time points for 60 min as a change in sGaw from baseline and computed as area under the curve (AUC), induced a neutropenia at 5 min and rebound neutrophilia at 2 h, and stimulated production of urinary eicosanoids. Bronchoconstriction was maximal at 5 min but had receded at 1 h; (AUC mean [95% Cl]; 20.0 [13.2, 26.8] at 3 h; 11.0 [5.3, 16.6] at 24 h) and was completely abolished by both doses of UK,74505 at 3 h and by the higher 100 mg dose at 24 h. PAF-induced neutropenia and rebound neutrophilia were abolished by both doses of drug; neutropenia at 5 min (expressed as mean [95% Cl] change from baseline; -2.5 x 10(9)/L [-2.9, -2.1] after P; -0.3 [-0.7, 0.1] after 25 mg; 0.1 [-0.3, 0.4] after 100 mg), neutrophilia at 2 h (2.0 [-1.3, 2.6] after P; -0.2 [-0.8, 0.5] after 25 mg; -0.1 [-0.8, 0.5] after 100 mg).(ABSTRACT TRUNCATED AT 250 WORDS)
Diagnostic Laparotomy and Splenectomy for Staging Hodgkin's Disease
Authors: STANLEY LOWENBRAUN
Journal: Annals of Internal Medicine (1970)

Diagnostic laparotomies and splenectomies were performed on 12 patients to determine more accurately the extent of Hodgkin's disease in the abdomen. Preoperatively, the patients were carefully staged as recommended by the Rye Conference in 1966. At laparotomy four out of nine positive lymphograms were uncorroborated by surgical findings and biopsies, as was one positive inferior vena cavogram. Splenic disease was found in four out of six patients whose preoperative evaluations were negative in this regard. Hodgkin's infiltration of porta hepatic, splenic hilar, and mesenteric lymph nodes was found in three, two, and one patient, respectively. In one patient a retroperitoneal mass was discovered that extended 4 cm laterally to nodes visualized by lymphography and outside usual fields for radiotherapy. None of the hepatic wedge biopsies were positive. Three patients had their stages changed on the basis of laparotomy findings, and an additional seven patients had changes in their known extent of lymphomatous involvement.