Tardive Dyskinesia Associated with Olanzapine
Authors: Andrés Herrán, Jose Luis Vázquez-Barquero
Journal: Annals of Internal Medicine (1999)

Letters6 July 1999Tardive Dyskinesia Associated with OlanzapineAndrés Herrán, MD and Jose Luis Vázquez-Barquero, PhDAndrés Herrán, MDUniversity Hospital Marqués de Valdecilla; Santander, Spain (Herrán)University Hospital Marqués de Valdecilla; Santander, Spain (Luis, Vázquez-Barquero) and Jose Luis Vázquez-Barquero, PhDUniversity Hospital Marqués de Valdecilla; Santander, Spain (Herrán)University Hospital Marqués de Valdecilla; Santander, Spain (Luis, Vázquez-Barquero)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-1-199907060-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Tardive dyskinesia is the most feared side effect of prolonged neuroleptic treatment (1). The new atypical antipsychotic agents are supposed to reduce the incidence of tardive dyskinesia. Olanzapine, for example, may also help alleviate preexisting symptoms of this condition (2). We report two cases of tardive dyskinesia that developed after olanzapine use.Patient A was a 30-year-old woman with schizophrenia. She had moderate rigidity and akinesia and clinical features of residual schizophrenia (apathy, anhedonia). Her global score on the Positive and Negative Syndrome Scale (3) was 60; this reflected mild psychopathology. She was being treated with haloperidol, ...References1. Ebadi M, Srinivasan SK. Pathogenesis, prevention, and treatment of neuroleptic-induced movement disorders. Pharmacol Rev. 1995;47:575-604. MedlineGoogle Scholar2. Kimberly HL, Craig GJ, Steven L, Carol DP. Marked reduction of tardive dyskinesia with olanzapine. Arch Gen Psychiatry. 1998;55:279-80. CrossrefMedlineGoogle Scholar3. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261-76. CrossrefMedlineGoogle Scholar4. Munetz MR, Benjamin S. How to examine patients using the Abnormal Involuntary Movement Scale. Hosp Comm Psychiatry. 1988;39:1172-7. MedlineGoogle Scholar5. Tollefson GD, Beasley CM, Tamura RN, Tran PV, Potvin JH. Blind, controlled, long-term study of the comparative incidence of treatment-emergent tardive dyskinesia with olanzapine or haloperidol. Am J Psychiatry. 1997;154:1248-54. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital Marqués de Valdecilla; Santander, Spain (Herrán)University Hospital Marqués de Valdecilla; Santander, Spain (Luis, Vázquez-Barquero) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClozapine Treatment of Olanzapine-induced Tardive Dyskinesia: A Case ReportOlanzapineReduction in Tardive Dyskinesia Symptoms During Treatment With Olanzapine or HaloperidolLes effets indésirables des psychotropes chez le sujet âgé : étude rétrospective de 35 casAntioxidants as a Treatment and Prevention of Tardive DyskinesiaThe tardive syndromesThe Neuroprotective Efficacy of VitaminsNEUROLEPTIC DRUGSThe Tardive SyndromesAdverse Effects of Atypical AntipsychoticsEpidemiology of tardive dyskinesia: Is risk declining with modern antipsychotics?OlanzapineAdverse Effects of Atypical Antipsychotics in the ElderlyTardive Dyskinesia in the Era of Typical and Atypical Antipsychotics. Part 2: Incidence and Management Strategies in Patients with SchizophreniaNeuroleptic-Induced Movement Disorders: Deconstructing Extrapyramidal SymptomsOlanzapine treatment for tardive dyskinesia in schizophrenia patients: a prospective clinical trial with patients randomized to blinded dose reduction periodsTardive Dyskinesia Associated with Olanzapine in a Neuroleptic-Naive Patient with SchizophreniaThe Epidemiology Of Tardive DyskinesiaHaloperidol-induced dyskinesia is associated with striatal NO synthase suppression: Reversal with olanzapineAtypical antipsychotics and mood stabilization in bipolar disorderCLASSIFICATION AND TREATMENT OF TARDIVE SYNDROMESExtrapyramidal symptom profiles in Japanese patients with schizophrenia treated with olanzapine or haloperidolEffects of Newer Antipsychotics on Extrapyramidal FunctionAntipsychotic drugsAtypical Antipsychotics in the Treatment of Bipolar DisorderOlanzapine 6 July 1999Volume 131, Issue 1Page: 72KeywordsAntipsychoticsDiagnostic and Statistical Manual of Mental DisordersDrugsEmotionsSchizophreniaTongue Issue Published: 6 July 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...