tbuckley/cabot-search huggingface dataset:
GLOMERULI: LOCAL AND FOCAL
Authors: WILLIAM J. KLEIN
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 November 1969GLOMERULI: LOCAL AND FOCALWILLIAM J. KLEIN JR., M.D.WILLIAM J. KLEIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-5-1025_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The presentation by Dr. Dunea on "Brucella Nephritis" (Ann. Intern. Med. 70: 783, 1969) was stimulating, but a common confusion about "local" and "focal" has been reinforced.When the words local and focal are used in the description of renal histopathology, it is the accepted convention that the former refers to change in part of a glomerulus whereas the latter denotes involvement of some but not all glomeruli.The legends for Figures 1 and 2 contain statements about focal changes in one glomerulus. Rather, this is a local change.The legend for Figure 7 describes focal atrophy... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM J. KLEINJR., M.D.Affiliations: Division of Nephrology Duke University Medical Center Durham, N. C. 27706 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1969Volume 71, Issue 5_Part_1Page: 1025-1025KeywordsAtrophyBrucellaHistopathologyNephritis ePublished: 1 December 2008 Issue Published: 1 November 1969 PDF downloadLoading ...
A DEFENSE OF GROUP MEDICINE
Authors: John W. Visher
Journal: JAMA (1922)

<h3>To the Editor:</h3> —The communication by Dr. Wilson on the disadvantages and limitations of clinic or group medicine inThe Journal, June 24, provoked in me a decided reaction. Much of the criticism he offered is true, but, as he said, can be applied with equal justice to the consultant and to the general practitioner. Other criticisms of group practice need only to be recognized to be obviated. A properly organized and managed modern clinic in a small city is far from being a "soulless corporation." Its members are conscientious physicians with as definite a clientele as the so-called family physician. What is the evidence that the average consultant or even general practitioner takes into account the individual's "psychologic reaction" any more definitely than does a member of a small group in a small city? The question whether specialists in the large cities and medical centers should unite into groups
Smoking bans reduce heart attack admissions
Authors: R. Dobson
Journal: BMJ (2008)

Bans on smoking substantially reduce hospital admissions for heart attacks, research has shown.

On the first anniversary of the ban on public smoking in England, a report shows that smoke-free laws worldwide reduce admissions by almost one fifth ( Preventive Medicine 2008 Jun 18; doi: 10.1016/j.ypmed.2008.06.007).

This meta-analysis of published studies shows that the effects were immediate. “The fact that many studies from so many locations around the world provide consistent findings of a substantial drop in acute myocardial infarction associated with the implementation of smoke-free laws increases the confidence that . . . smoke-free policies have immediate and …
The Meaning of Movement
Authors: R. Pierloot, H. van Coppenolle
Journal: Psychotherapy and Psychosomatics (1973)

The problem of the connection between psychological functioning and somatic process can be approached by studying the content of psychological experiences related to bodily processes. Movement, having been a favourite subject for theoretical phenomenological descriptions, offers the opportunity for such a study. In our pilot study we have tried to describe different patterns of content in movement experience. Therefore, we analyzed the motivations for liking or disliking movement situations indicated by 100 female psychiatric patients, having been involved in movement therapy. Four types of experience content emerge: the pleasure seeking, the emotional expressive, the communicative and the individual affirmative. Based on open-end questioning in an investigation without circumscribed comparable groups, these findings are considered only as a preliminary basis for further research, in developing a tool for investigating the influence of psychopathological and personality factors on the meaning experienced in movement situations.
Evolution of poliovirus since introduction of attenuated vaccine.
Authors: Y E Cossart
Journal: BMJ (1977)

Genetic marker tests were performed on 997 strains of poliovirus isolated from patients with neurological disease and from healthy people in England and Wales. Before the introduction of live attenuated vaccine most strains could multiply at raised temperatures. Now, however, many strains isolated from cases of poliomyelitis or from healthy persons with no known contact with vaccine cannot grow above 37 degrees C, and in this respect resemble the vaccine strains. The three serotypes are also much more evenly represented. Hence probably to a limited extent the vaccine-like strains have established themselves in the community.
Abstract 866: D,L-Sulforaphane-induced apoptosis in human breast cancer cells is regulated by growth factor adaptor protein p66Shc
Authors: Kozue Sakao, Shivendra V. Singh
Journal: Cancer Research (2011)

Abstract D,L-Sulforaphane (SFN), a synthetic racemic analogue of broccoli constituent L-sulforaphane, inhibits chemically-induced cancer in experimental rodents. SFN administration also suppresses cancer development in transgenic mouse models. Anticancer effect of SFN is associated with apoptosis induction but the mechanism of cell death is not fully understood. Using MDA-MB-231 (an estrogen-independent cell line) and MCF-7 (an estrogen-responsive cell line) human breast cancer cells as a model, we now demonstrate that the SFN-induced apoptosis is regulated by growth factor adapter protein p66Shc. Exposure of MDA-MB-231 and MCF-7 cells to SFN resulted in increased Ser36 phosphorylation of p66Shc. Immortalized mouse embryonic fibroblasts derived from p66Shc knockout mouse were significantly more resistant to SFN-mediated growth inhibition (judged by trypan blue dye exclusion assay) and apoptosis induction (judged by cytoplasmic histone-associated apoptotic DNA fragmentation) compared with embryonic fibroblasts from wild-type mouse. Moreover, transient transfection of MDA-MB-231 and MCF-7 cells with p66Shc-targeted siRNA conferred significant protection against SFN-induced cytoplasmic histone-associated DNA fragmentation. Protein level of prolyl isomerase 1 (Pin1), a protein implicated in mitochondrial translocation of p66Shc, was decreased on a 24-hour treatment with SFN in both MDA-MB-231 and MCF-7 cells. However, apoptosis induction resulting from SFN exposure was not affected by ectopic expression of Pin1 (MCF-7). In conclusion, the present study provides novel insights into the molecular circuitry of SFN-induced apoptosis involving p66Shc. This investigation was supported by the USPHS grant RO1 CA115498-05, awarded by the National Cancer Institute. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 866. doi:10.1158/1538-7445.AM2011-866
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
Authors: John R B Perry, Lisette Stolk, Nora Franceschini, Kathryn L Lunetta, Guangju Zhai, Patrick F McArdle, Albert V Smith, Thor Aspelund, Stefania Bandinelli, Eric Boerwinkle, Lynn Cherkas, Gudny Eiriksdottir, Karol Estrada, Luigi Ferrucci, Aaron R Folsom, Melissa Garcia, Vilmundur Gudnason, Albert Hofman, David Karasik, Douglas P Kiel, Lenore J Launer, Joyce van Meurs, Michael A Nalls, Fernando Rivadeneira, Alan R Shuldiner, Andrew Singleton, Nicole Soranzo, Toshiko Tanaka, Jenny A Visser, Michael N Weedon, Scott G Wilson, Vivian Zhuang, Elizabeth A Streeten, Tamara B Harris, Anna Murray, Tim D Spector, Ellen W Demerath, André G Uitterlinden, Joanne M Murabito
Journal: Nature Genetics (2009)
Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy
Authors: Christopher Schliehe, Constanze Schliehe, Marc Thiry, Ulrich I. Tromsdorf, Joachim Hentschel, Horst Weller, Marcus Groettrup
Journal: Journal of Controlled Release (2011)
A METHOD OF BIMANUAL ROTATION IN OCCIPITO-POSTERIOR POSITIONS OF THE VERTEX.
Authors: WILLIAM D. PORTER
Journal: JAMA (1907)

Practically all methods which have been recommended for manual rotation in occipito-posterior positions of the vertex involve grasping the head with a hand in the vagina. To grasp such a smooth, globular, slippery mass securely is not easy. If such a grasp be secured the rotating force which can be exerted is inadequate in difficult cases. The attempt to grasp the head usually lifts it up to a higher plane of the pelvis, and this elevation of the head often results in diminished flexion; both undesirable occurrences. In right occipito-posterior positions of the vertex, which, for convenience, we shall assume throughout this paper unless otherwise stated, the grasping of the occiput necessarily moves it away from the right side of the pelvis, against which it is uniformly found. This disturbance of position often leads to a serious complication. With the occiput snug against the right side of the pelvis there
1276 Activated hepatic stellate cells express a variant hyaluronic acid receptor, CD44-V6, that is required for migration
Authors: S KIKUCHI, S WANG, C GRIFFIN
Journal: Hepatology (2003)

The 22 γ-protocadherins (γ-Pcdhs) potentially specify thousands of distinct homophilic adhesive interactions in the brain. Neonatal lethality of mice lacking the Pcdh-γ gene cluster has, however, precluded analysis of many brain regions. Here, we use a conditional Pcdh-γ allele to restrict mutation to the cerebral cortex and find that, in contrast to other central nervous system phenotypes, loss of γ-Pcdhs in cortical neurons does not affect their survival or result in reduced synaptic density. Instead, mutant cortical neurons exhibit severely reduced dendritic arborization. Mutant cortices have aberrantly high levels of protein kinase C (PKC) activity and of phosphorylated (inactive) myristoylated alanine-rich C-kinase substrate, a PKC target that promotes arborization. Dendrite complexity can be rescued in Pcdh-γ mutant neurons by inhibiting PKC, its upstream activator phospholipase C, or the γ-Pcdh binding partner focal adhesion kinase. Our results reveal a distinct role for the γ-Pcdhs in cortical development and identify a signaling pathway through which they play this role.
Studies on the effect of vagotomy on small intestinal motility using the radio-telemetering capsule
Authors: B. Ross, B. W. Watson, A. W. Kay
Journal: Gut (1963)

The radio-telemetering capsule (radio-pill) has been used to study the return of motility in the small bowel after vagotomy with a drainage procedure, gastric operations not involving vagotomy, and non-gastric operations. Small intestinal movements returned in about 10 hours after vagotomy, about four hours after the various gastric operations, and within one hour in those operations not involving handling of the viscera. The implications of these results are discussed in relation to the management of patients after gastric surgery.
Stress Electrocardiograms-Reply
Authors: David H. Spodick
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Another Thyrotoxic Criminal?
Authors: FRANK DITURI
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 September 1971Another Thyrotoxic Criminal?FRANK DITURI, M.D., F.A.C.P.FRANK DITURI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-3-478 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After reading the article, "Three Thyrotoxic Criminals," by Davis and associates (Ann Intern Med 74:743-745, 1971), I was prompted to review a chart on a patient I had examined at the request of the Public Defender of a neighboring county. The patient was a 27-year-old man on trial for possession of a sawedoff shotgun, a felony in California. Because of a history of thyrotoxicosis, the Public Defender asked if I would examine the patient and give medical testimony at his trial.The young man's medical and criminal history dated back to the age of 18 when he... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 10401 Balboa Blvd. Granada Hills, Calif. 91344 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1971Volume 75, Issue 3Page: 478-479KeywordsChartsFirearm injuries Issue Published: 1 September 1971 PDF DownloadLoading ...
Prenatal growth, subsequent marital status, and mortality: longitudinal study
Authors: D. Vagero
Journal: BMJ (2002)

We replicated the studies undertaken by Phillips et al to test their propositions that early growth restriction which they claim leads people to remain unmarried is linked with the susceptibility to cardiovascular disease and that the link between marital status and health may have its origin during intrauterine life. 1 2

The Uppsala birth cohort study is a lifelong follow up study of people born in 1915-29. 3 4 We used official registers to follow their marital status and mortality from 1970 through to 1995. Complete data were available for 5577 men and 5227 women. We collected school results at age 10 and body height (for men) at conscription (age 18) for a random sample of 405 boys and 411 girls (8%).

To indicate fetal growth we calculated birth weight for …
Release of triamcinolone acetonide from mucoadhesive polymer composed of chitosan and poly(acrylic acid) in vitro
Authors: Jae-Soon Ahn, Hoo-Kyun Choi, Myong-Kwan Chun, Jei-Man Ryu, Jae-Hee Jung, Yue-Un Kim, Chong-Su Cho
Journal: Biomaterials (2002)
TREATMENT OF FIBROUS ANKYLOSIS OF KNEE AND ELBOW JOINTS
Authors: S. D. Calonge
Journal: JAMA (1927)

In fractures, dislocations, trauma or infections adjacent to or involving the articulations of the knee or elbow, temporary or permanent loss of function of these joints occurs in a large percentage of cases. In more than 90 per cent the disability is due to limited flexion caused by fibrous formation affecting the joint proper or the tendons and ligaments concerned in the leverage as applied in normal motion of these articulations. The appliances here shown are indicated in this class of cases. In a small percentage actual bony ankylosis occurs and must be dealt with as another surgical problem; therefore this class of cases will not be benefited by use of the appliances here presented. The appliance for increasing the flexion of the elbow (as shown in the accompanying diagram) consists of: (1) a figure-of-eight shoulder strap and (2) a 1¼ inch wide elastic band passing from a point over
Personalized Messages Invite More Mammography
Authors: Rebecca Voelker
Journal: JAMA (1994)

TAILORED LETTERS and telephone calls may emerge as effective new weapons in the stepped-up fight against breast cancer. The tactics can't come quickly enough. New national figures show that more women past age 40 have received mammograms in recent years, but most still are not routinely screened. Conflicting guidelines don't help. Many physicians now question what constitutes "routine" screening, so experts say it's increasingly important to discuss mammography, along with breast self-examination, with patients. And even though family physicians may be trying to prompt more women to have mammograms, experts attribute low screening rates to high-risk patients being cared for by specialists who overlook the need for mammography. <h3>Patterns in Mammography</h3> From 1987 to 1990, the number of women older than age 40 who received a mammogram in the past year nearly doubled, from 17% to 33%, according to figures compiled by the National Center for Health Statistics, Hyattsville, Md.
On Combination Therapy of Diabetes With Metformin and Dipeptidyl Peptidase IV Inhibitors
Authors: Simon A. Hinke, Christopher H. S. McIntosh, Torsten Hoffmann, Kerstin Kühn-Wache, Leona Wagner, Joachim Bär, Susanne Manhart, Michael Wermann, Raymond A. Pederson, Hans-Ulrich Demuth
Journal: Diabetes Care (2002)

Recently, data were presented showing that metformin increased plasma active glucagon-like peptide (GLP)-1[7–36NH2] concentrations in obese nondiabetic male patients (1), and it was suggested that metformin was a direct dipeptidyl peptidase (DP) IV inhibitor. Contradiction of this hypothesis is simply found by examining the modes of action of metformin and of the DP IV inhibitors. Although the specific molecular target of metformin is still unknown, biguanides generally act to sensitize peripheral tissues to insulin action (particularly, skeletal muscle) and inhibit hepatic gluconeogenesis and glycogenolysis (2,3,4). In contrast, DP IV inhibitors act to enhance the insulin response to a meal, via preservation of …
Treatment and Metabolic Studies with Human Growth Hormone in Retarded Growth.
Authors: Herbert Gershberg
Journal: Annals of Internal Medicine (1966)

s1 May 1966Treatment and Metabolic Studies with Human Growth Hormone in Retarded Growth.Herbert Gershberg, M.D., F.A.C.P., Dobroslav Matiasevic, M.D., Zenaida C. Javier, M.D.Herbert Gershberg, M.D., F.A.C.P.Search for more papers by this author, Dobroslav Matiasevic, M.D.Search for more papers by this author, Zenaida C. Javier, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1161_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEighteen subjects with retarded growth were treated with human growth hormone (HGH) for up to 7 years. The group included 5 with idiopathic hypopituitarism, 1 with isolated growth hormone deficiency, 3 with achondroplasia and dyschondroplasia, 1 with vitamin D-resistant rickets, 1 with malabsorption resulting from massive resection of the small intestine, 1 with regional ileitis, 1 with gonadal dysgenesis, 2 with corticosteroid-induced dwarfism, 1 with Fanconi's anemia, 1 with glycogen-storage disease, and 1 with constitutional dwarfism.Significant improvement in growth (at least twice the pretreatment rate) was most marked in the children with pituitary insufficiency and in the 2 children... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Herbert Gershberg, M.D., F.A.C.P.; Dobroslav Matiasevic, M.D.; Zenaida C. Javier, M.D.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1161-1161KeywordsAnemiaChildrenGrowth hormoneHuman growth hormoneSmall intestine ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
Endosonography Versus Helical Computed Tomography for Locoregional Staging of Gastric Cancer
Authors: M. Polkowski, J. Palucki, E. Wronska, A. Szawlowski, A. Nasierowska-Guttmejer, E. Butruk
Journal: Endoscopy (2004)

Background and Study Aims: Endosonography (EUS) has been shown to be more accurate than incremental computed tomography (CT) in the local (T) and regional (N) staging of gastric carcinoma; however, EUS has never been compared with helical CT (HCT). The fifth edition of the TNM classification changed the guidelines for N-staging of gastric carcinoma. The accuracy of imaging methods in this new system remains unknown. Patients and Methods: Staging accuracy of EUS and HCT were compared prospectively with pathological or intraoperative findings in 88 gastric carcinoma patients. Staging was done according to the fourth and fifth editions of the TNM classification. EUS was done with a radial echo endoscope, and HCT with a scanner with two rows of detectors (two-phase contrast-enhanced scanning of a water-filled stomach). Results: The T-staging accuracy of EUS (63 %, CI 52 - 73 %) was superior to the accuracy of HCT (44 %, CI 34 - 55 %; P = 0.021). N-staging accuracy of both methods was similar when the fourth edition of the TNM classification was used (EUS 47 %, CI 34 - 60 %; HCT 52 %, CI 38 - 65 %). However, HCT was more accurate than EUS when the fifth edition of the classification was applied (EUS 30 %, CI 18 - 43 %, HCT 47 %, CI 34 - 60 %; P = 0.044). The accuracy of detection of lymph node metastases was similar for both methods (EUS 67 %, CI 54 - 78 %; HCT 77 %, CI 64 - 86 %). Conclusions: EUS is more accurate than HCT in the T-staging of gastric carcinoma. Both methods are comparable for N-staging, when this is done according to the older, fourth edition of the TNM classification. If the fifth edition is used, EUS is less accurate than HCT.
Propranolol to Treat Hemangiomas of Infancy: Safety and Side Effect Recognition
Authors: Jonathan A. Dyer
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal