tbuckley/cabot-search huggingface dataset:
c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells
Authors: Justine E. Roderick, Jessica Tesell, Leonard D. Shultz, Michael A. Brehm, Dale L. Greiner, Marian H. Harris, Lewis B. Silverman, Stephen E. Sallan, Alejandro Gutierrez, A. Thomas Look, Jun Qi, James E. Bradner, Michelle A. Kelliher
Journal: Blood (2014)
Skeletal Involvement in Secondary Syphilis Detected by Bone Scanning
Authors: Robert R. Tight
Journal: JAMA (1976)

IN ADULTS, bony involvement in early acquired syphilis has been reported infrequently.<sup>1</sup>We describe a patient with secondary syphilis in whom clinical findings indicated syphilitic periostitis of the frontal bones and clavicles. Roentgenograms of these bones were normal, but a bone scan showed abnormalities. <h3>Report of a Case</h3> A 22-year-old man was hospitalized with a chief complaint of a painful, red, swollen left eye for approximately one month. Also, he had experienced headaches, myalgia, cervical and left preauricular lymphadenopathy, and chills with fever to 38.3 C. Three days before admission, he noted erythema, swelling, and tenderness over the left sternoclavicular joint and a nonpruritic erythematous maculopapular rash over his face and palms. His temperature was 37.6 C; pulse rate, 100 beats per minute; and blood pressure, 105/65 mm Hg. The left periorbital soft tissues and both left eyelids were erythematous and edematous. The left supraorbital ridge was exquisitely tender.
Creation and biochemical analysis of a broad-specific claudin binder
Authors: Azusa Takahashi, Yumiko Saito, Masuo Kondoh, Kyohei Matsushita, Susanne M. Krug, Hidehiko Suzuki, Hirofumi Tsujino, Xiangru Li, Hiroshi Aoyama, Koji Matsuhisa, Tadayuki Uno, Michael Fromm, Takao Hamakubo, Kiyohito Yagi
Journal: Biomaterials (2012)
A Lesson from Canada: Ontario's Health Insurance
Authors: Osler L. Peterson
Journal: New England Journal of Medicine (1978)

Mueller, a Canadian surgeon, describes Ontario's version of national health insurance in this week's issue of the Journal (p. 535). Though his subject is Canadian, the message is evidently designed for United States physicians. Although a number of comparisons of medical care in the United States and other countries, mainly European, have raised interesting questions about the importance of widely varying rates of expenditure, hospitalization, surgery and other issues, we in the United States have neglected to inform ourselves about what is happening in Canada, a nation very much like our own. Obviously, we should learn whatever we can from . . .
Abstract 1272: MALDI imaging and next generation sequencing for dissecting prostate cancer heterogeneity
Authors: Phillip Stahl, Markus Wurlitzer, Hartmut Schlüter, Herbert Thiele, Michael Becker, Ronald Simon, Joachim Weischenfeldt, Jan Korbel, Sarah Minner, Guido Sauter
Journal: Cancer Research (2012)

Abstract Prostate cancer is often heterogeneous with multiple tumor foci within the same prostate. MALDI (Matrix-Assisted Laser Desorption/Ionization) mass spectrometry imaging (MSI) allows for a comprehensive profiling of the molecular phenotype on the protein, peptide, lipid, and metabolite level across entire tissue slides without prior enrichment of tumor cells. This study aims in a MALDI-based discrimination of cancer areas that are heterogeneous with respect to morphology and molecular features. We established a method for cryopreservation of entire prostates from cancer patients, and build tissue microarrays from individual cancerous prostates representing &amp;gt;30 different areas of the primary tumor as well as multiple lymph node metastases. We analyzed these arrays for ERG fusion by FISH and for peptide signatures by MALDI MSI. In addition, 2 selected tumor areas and 4 different lymph node metastases from one prostate were subjected to paired end next generation sequencing. MALDI identified 5 masses that were specific for epithelial cells. One particular mass was strongly related to presence of ERG fusion. In one prostate, we identified another mass that was present only in 2/35 tissue spots from the primary tumor as well as in 4/10 lymph nodes. Deep sequencing of different tumor areas of this case identified distinct patterns of structural genetic alterations. A cluster analysis showed that all samples were clonally related, and identified the area inside the primary tumor that gave rise to the metastases. In conclusion, these data suggest that MALDI imaging and next generation sequencing allow for identification of genetic and proteome patterns that correspond to metastatic spread of prostate cancer cells. A combination of both techniques is suited to dissect the genetic background of distinct MALDI signatures. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1272. doi:1538-7445.AM2012-1272
Modern medicine and war: Didn't we do well?
Authors: T. Delamothe
Journal: BMJ (1988)

Medicine and the munitions industry are traditionally regarded as the beneficiaries of war. Another war, another medical advance (or two) the story usually goes. A recent symposium at the Wellcome Institute for the History of Medicine, London, did not contradict this view but did attempt to put the medical advances in context. Some advances have been important in giving a newly forming group an identity, some have been discredited, some didn't last beyond the war that spawned them. Most contributors would probably concur with the opinion of medical historian and military man Fielding Garrison, who wrote in 1929 (of the first world war),  medical innovations and the inventions of the war period seem clever, respectable, but not particularly brilliant. The administrative achievement was, how? ever, truly remarkable.1
Study of Serum Lipid Levels in Twins
Authors: B. M. Rifkind, J. A. Boyle, M. Gale, W. Greig, W. W. Buchanan
Journal: Cardiovascular Research (1968)

The influence of genetic and environmental factors on the variation in serum cholesterol, triglyceride, phospholipid, and β-lipoprotein levels was investigated by means of a twin study of 108 like-sex twin pairs. The results suggest that genetic influences are weak, and that environmental influences are established before twins separate to live apart.
The surface area of the hand and the palm for estimating percentage of total body surface area: results of a meta-analysis
Authors: J. Rhodes, C. Clay, M. Phillips
Journal: British Journal of Dermatology (2013)

The estimation of body surface area involvement is an important tool. Hand surface area (HSA) or palm surface area (PSA) is commonly used for the estimate, with an assumption that HSA represents 1% of the total body surface area (TBSA).To establish (i) the most accurate values for mean HSA% and PSA% of TBSA, and (ii) the variability of these with patient variables.The PubMed, Embase and Cochrane databases were searched and 14 eligible studies were identified. Weighted means of HSA% and PSA% were produced. The meta-analysis examined systematic variation associated with sex, age (for children), body mass index (BMI) and ethnic group using random-effects models.HSA% is 13% lower than the accepted 1% value for all adults (P = 0.004). PSA% is not significantly different from the accepted 0.5% value (P = 0.82). Men have a significantly higher HSA% than women (P < 0.0001). Children have a significantly higher HSA% than adults (P < 0.0001). HSA% falls with increasing BMI in adults (P < 0.0001). A comparison of European, Chinese and Indian subcontinent ethnic groups showed that each group was different from the others (P < 0.05).The use of HSA equating to 1% TBSA results in an overestimate for adults (particularly women) and an underestimate for children. PSA equating to 0.5% TBSA appears to be suitable for adults. Patient variables including sex and BMI result in variation of HSA as a percentage of TBSA. The heterogeneity of the included studies and the lack of data for children are the major limitations of this study.
Incidence of primary aldosteronism uncomplicated "essential" hypertension. A prospective study with elevated aldosterone secretion and suppressed plasma renin activity used as diagnostic criteria
Authors: L. M. Fishman
Journal: JAMA (1968)

In a prospective study of the incidence of primary aldosteronism among patients with "essential" hypertension, this diagnosis could be excluded in 87 of 90 patients by the demonstration of normal aldosterone secretion or lack of suppression of plasma renin activity or both. In contrast, at least four of ten patients observed during the same period because of concomitant hypertension and unprovoked hypokalemia were proven to have primary aldosteronism. Primary aldosteronism is, thus, a relatively rare cause of hypertension among patients with normal serum potassium concentrations, but should be carefully considered as a possible cause of hypertension among patients with hypokalemia. Subnormal plasma renin activity was found to be a characteristic of patients with "essential" hypertension as a group; marked suppression of plasma renin activity was found in five (21%) of 24 patients with "essential" hypertension. Thus, although subnormal plasma renin activity can be used to distinguish primary from secondary aldosteronism, taken by itself, this finding is of limited value in diagnosis since it also occurs in many patients with "essential" hypertension.
Grow the US National Health Service Corps
Authors: Jonathan F. Saxton
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The uniform anatomical gift act. A model for reform
Authors: A. M. Sadler
Journal: JAMA (1968)

Few events in recent legal history have as great a potential for beneficial impact on the medical community as the final approval of the Uniform Anatomical Gift Act on July 30, 1968, at the most recent National Conference of the Commissioners on Uniform State Laws. The Uniform Act, which is appended, received the endorsement of the American Bar Association on Aug 7, 1968. The Act is designed to facilitate the donation and use of human tissues and organs for transplantation and other medical purposes and provides a favorable legal environment for such activities.  The National Conference of Commissioners on Uniform State Laws is composed of law professors, lawyers, and judges, representing every state, whose function is to help make state laws more uniform and up to date. The Uniform Anatomical Gift Act is the product of three years of intensive study by a special committee of the conference and is particularly
Response to Letter Regarding Article, “Magnetic Resonance Imaging With 3-Dimensional Analysis of Left Ventricular Remodeling in Isolated Mitral Regurgitation: Implications Beyond Dimensions”
Authors: Chun G. Schiros, James D. Gladden, Donald Clark, Himanshu Gupta, Steven G. Lloyd, David C. McGiffin, Mustafa I. Ahmed, Inmaculada Aban, Louis J. Dell’Italia, Gilbert Perry, Thomas S. Denney
Journal: Circulation (2013)

We thank Drs Vallakati and Sharma for their comments and appreciate their interest in our work. 1As pointed out, we demonstrated the Bullet formula underestimates left ventricular end-systolic volume, and further analysis does indeed demonstrate the mean Bullet formula-calculated left ventricular ejection fraction is significantly higher than left ventricular ejection fraction measured by magnetic resonance imaging (67%±9% versus 61%±7%, P<0.0001).Referral echocardiograms in our study used a visual estimate of left ventricular ejection fraction.Furthermore, only a very small portion of the patients were found to have a left ventricular ejection fraction <60% by magnetic resonance imaging measurement; almost all had left ventricular end-systolic diameter <40 mm, and thus, we did not perform analyses based on referral echocardiographic assessment.It is of great interest whether an accurate echocardiographic volumebased assessment of end systole and ejection fraction is comparable to magnetic resonance imaging-derived measures in the evaluation of mitral regurgitation.Given the wide availability of echocardiography now with potential for 3-dimensional analysis, this represents an exciting area of future study.In our reported study of surgical patients with severe mitral regurgitation, regurgitant volume was not significantly associated with postoperative left ventricular dysfunction.However, this result must be interpreted with caution because of the relatively small sample size.We did not perform specific imaging to assess atrial remodeling and thus are reluctant to comment on its relationship with outcomes.
Not so fast: Domain-general factors can account for selective deficits in grammatical processing
Authors: Elizabeth Bates, Frederic Dick, Beverly Wulfeck
Journal: Behavioral and Brain Sciences (1999)

Normals display selective deficits in morphology and syntax under adverse processing conditions. Digit loads do not impair processing of passives and object relatives but do impair processing of grammatical morphemes. Perceptual degradation and temporal compression selectively impair several aspects of grammar, including passives and object relatives. Hence we replicate Caplan &amp; Waters's specific findings but reach opposite conclusions, based on wider evidence.
A1-adenosine receptor inhibition of adenylate cyclase in failing and nonfailing human ventricular myocardium.
Authors: R E Hershberger, A M Feldman, M R Bristow
Journal: Circulation (1991)

BACKGROUND Receptors that couple via the stimulatory G protein, Gs, to adenylate cyclase and to a positive inotropic response have been extensively investigated in falling human heart. In contrast, much less is known about receptors, such as the A1-adenosine receptor, that couple to adenylate cyclase via the inhibitory G protein, Gi, to give a negative inotropic response. Activation of such Gi-coupled receptors might worsen heart failure. Furthermore, alpha Gi is increased in failing human ventricular myocardium, which may enhance inhibitory receptor coupling to adenylate cyclase. METHODS AND RESULTS A1-Adenosine receptor inhibition of adenylate cyclase was examined in crude particulate preparations derived from 12 nonfailing and 12 failing human left ventricles. Experimental conditions were designed for maximal inhibitory responses. Dose-response curves were performed with the selective A1-adenosine receptor agonist R-phenylisopropyl-adenosine (R-PIA). No differences in nonfailing versus failing heart were observed for basal adenylate cyclase activity (49.0 +/- 4.1 versus 45.7 +/- 2.6 pmol cyclic AMP/min/mg), maximal R-PIA-mediated inhibition (31.1 +/- 2.6 versus 30.2 +/- 1.6 pmol cyclic AMP/min/mg), ED50 (R-PIA x 10(-7) 1.28 +/- 0.10 versus 1.36 +/- 0.08), or slope (1.06 +/- 0.06 versus 1.03 +/- 0.10), respectively. Furthermore, fluoride, forskolin, and manganese adenylate cyclase activation were not different in failing heart, which is consistent with no change in the catalytic unit of adenylate cyclase. The inhibitory G protein alpha Gi, as quantitated by pertussis toxin-catalyzed ADP-ribosylation, was increased in failing heart (105.7 +/- 5.8 versus 132.7 +/- 3.4 optical density units, p less than 0.003). Basal adenylate cyclase activity was reduced in failing heart (7.8 +/- 0.8 versus 4.5 +/- 0.4 pmol cyclic AMP/min/mg, p less than 0.005) with assay conditions designed to assess G protein effects. CONCLUSIONS The A1-adenosine receptor pathway exerts a major inhibitory effect on human myocardial adenylate cyclase activity. Although alpha Gi was increased in failing heart, A1-adenosine receptor inhibition of adenylate cyclase was not altered in preparations of failing versus nonfailing human ventricular myocardium.
The Uses of Psychiatry in the Law: A Clinical View of Forensic Psychiatry
Authors: Manuel P. Pardo
Journal: JAMA (1980)

The authoritative, well-organized, objectively presented material of<i>The Uses of Psychiatry in the Law</i>came out of a series of lectures given to law students by Dr Walter Bromberg. A highly respected teacher and clinician with vast courtroom experience, Bromberg has aptly subtitled his book, "A Clinical View of Forensic Psychiatry." In his preface he modestly claims that his book will be "comprehensive but not exhaustive." I think the author has succeeded in presenting a refreshing and highly enlightening piece of work containing useful and practical information. Without being carried away by philosophical discussions on moral and ethical issues in forensic psychiatry, he successfully manages to cover virtually all of the important areas in law and psychiatry. The presentation begins with a brief introduction and moves smoothly to the courtroom scene where the psychiatrist-witness is put through the process of qualifying as an expert. Bromberg includes many verbatim excerpts of
Flu Shots for Stroke Prevention?
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lysosomes, Cortisone, and Aspergillosis
Authors: PAUL P. CARBONE
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 March 1968Lysosomes, Cortisone, and AspergillosisPAUL P. CARBONE, M.D.PAUL P. CARBONE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-3-708 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of infections in man by ordinarily nonpathogenic organisms represents a problem to the internist and the surgeon who manage patients with hematologic malignancies and renal transplants (1-3). In these complex clinical situations many factors, including the underlying disease process, the use of immunosuppressive drugs and corticosteroids, and leukopenia, have been implicated. Rarely can the pathogenesis of the infection be defined. However, in the latest of a series of papers by Epstein, Verney, Miale, and Sidransky (4), a very definitive analysis of the pathogenesis of experimental aspergillosis in mice has been suggested. Utilizing the cortisone-treated mouse as an experimental...References1. TORACH RM: Fungus infections associated with antibiotics and steroid therapy. Amer. J. Med. 22: 872, 1957. CrossrefMedlineGoogle Scholar2. HUTTER RV and COLLINS HS: Occurrence of opportunistic fungus infections in a cancer hospital. Lab. Invest. 11: 1035, 1962. MedlineGoogle Scholar3. RIFKIND D, MARCHIORO TL, SCHNECK SA, and HILL RB: Systemic fungal infections complicating renal transplantation and immunosuppressive therapy. Amer. J. Med. 43: 28, 1967. CrossrefMedlineGoogle Scholar4. EPSTEIN SM, VERNEY E, MIALE TD, and SIDRANSKY H: Studies on the pathogenesis of experimental pulmonary aspergillosis. Amer. J. Path. 51: 769, 1967. MedlineGoogle Scholar5. LEADER RW: Lower animals, spontaneous disease, and man. Arch. Path. (Chicago) 78: 390, 1964. MedlineGoogle Scholar6. WEISSMAN G: Lysosomes. New Eng. J. Med. 273: 1084, 1143, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL P. CARBONE, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1968Volume 68, Issue 3Page: 708-709KeywordsAspergillosisDrugsHematologic malignanciesImmunosuppressivesLysosomesPathogenesisRenal transplantationSurgeons ePublished: 1 December 2008 Issue Published: 1 March 1968 PDF downloadLoading ...
Statues to Medical Men.
Authors: W. H. Sharp
Journal: JAMA (1894)

Parkersburg, W. Va., Nov. 19, 1894. <h3>To the Editor:</h3> —Dr. E. Cutter, in his note in the Journal of November 17, trusting to his memory, falls into an error in writing of a statue to Dr. J. D. Crawford, the discoverer of ether in 1842. It was Dr. Crawford W. Long, of Madison County, Georgia, who first used ether as an anesthetic in 1842, and who neglected to make his discovery known to the world until 1849. I doubt whether there is a statue to his memory in the rotunda at Washington. Probably the statue in the rotunda is in honor of W. Harris Crawford, one of Georgia's most distinguished citizens, who was Senator, Minister to France, Secretary of War and Treasury, and nominee for President in the congressional caucus with Jackson, Clay and Adams; at which time Adams was elected. These statues are there by action of the National
Elderly urged to get Medicare-paid flu shots; agencies try for improved awareness, accessibility
Authors: C. Marwick
Journal: JAMA (1994)

AS THE DAYS shorten with the approach of winter, the risk of influenza rises. Get immunized. It saves lives, says Bruce Vladeck, PhD, administrator of the Health Care Financing Administration (HCFA). Vladeck's agency is making a special effort this year to encourage Medicare beneficiaries to get immunized against influenza.  By definition, Medicare beneficiaries, Americans 65 years of age and older, are one of the high-risk groups recommended to receive the annual influenza vaccination (along with people with chronic conditions such as lung or heart disease, diabetes, and cancer). This is the second year that they are eligible to receive influenza vaccination without charge. The flu vaccination became a covered benefit in May 1993, after its potential cost-effectiveness was established by the Medicare Influenza Vaccine Demonstration.  Last year Medicare paid for nearly 10 million influenza vaccinations. If the agency reaches this year's goal of immunizing 60% of eligible beneficiaries— 15 million