Endogenous Digoxin-like Material in Patients with Liver Disease
Authors: L. SHILO
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 October 1985Endogenous Digoxin-like Material in Patients with Liver DiseaseL. SHILO, M.D., M. S. SHAPIRO, M.D., S. DOLEV, B.A., L. SHENKMAN, M.D.L. SHILO, M.D.Search for more papers by this author, M. S. SHAPIRO, M.D.Search for more papers by this author, S. DOLEV, B.A.Search for more papers by this author, L. SHENKMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-4-643_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Endogenous digoxin-like immunoreactivity has been found in serum during the third trimester of pregnancy (1) and the neonatal period (2) and in patients with uremia (3) and, most recently, liver disease (4). We now corroborate the presence of this immunoreactivity in cirrhosis, and report its presence in acute viral hepatitis.Venous blood was obtained from ten patients with acute viral hepatitis and six patients with cirrhosis of the liver. Levels of digoxin were measured by two separate radioimmunoassays: a solid-phase radioimmunoassay for digoxin (Quanticoat; Kallestad Lab Inc. , Austin, Texas); and a double-antibody radioimmunoassay (RIANEN; New England...References1. GRAVESVALDESBROWN SRB. Endogenous digoxin-like immunoreactive substance in human pregnancies. J Clin Endocrinol Metab. 1984;58:748-51. CrossrefMedlineGoogle Scholar2. VALDESGRAVESBROWN RSB. Endogenous substances in newborn infants causing false positive digoxin measurements. J Pediatrics. 1983;102:947-50. CrossrefMedlineGoogle Scholar3. GRAVESBROWNVALDES SBR. An endogenous digoxin-like substance in patients with renal impairment. Ann Intern Med. 1983;99:604-8. LinkGoogle Scholar4. NANJIGREENWAY AR. Falsely raised plasma digoxin concentrations in liver disease. Br Med J. 1985;290:432-3. CrossrefMedlineGoogle Scholar5. BALZANCLERICOGRAZIA DEL CHICCA SAM. Digoxin-like immunoreactivity in normal human plasma and urine, as detected by a solid-phase radioimmunoassay. Clin Chem. 1984;30;450-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Meir Hospital Kfat Saba The Sackler School of Medicine Tel Aviv Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe influence of feeding regimens on endogenous digoxin-like immunoreactive substance concentrations in infantsInfluence of digoxin-like immunoreactive factor on late complications in patients with diabetes mellitusEndogenous factors with immunological and biological activity similar to cardiac glycosides: Biochemical and pathophysiological implicationsThe Contribution of Steroids to Digoxin-Like Immunoreactivity in Cord BloodEndogenous Digoxin-like Immunoreactive Factor Is Elevated in Advanced Chronic Respiratory FailureAtrial natriuretic peptide administration to normal and salt depleted rats — Effects on digoxin-like immunoreactive factor, aldosterone, acth, and renal function 1 October 1985Volume 103, Issue 4Page: 643-643KeywordsBloodCirrhosisHepatitisLiverLiver diseasesPregnancyRadioimmunoassays Issue Published: 1 October 1985 PDF downloadLoading ...