Primary Bile Duct Cancer and von Recklinghausen Disease
Authors: DIRK P. SPRENGERS
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 May 1987Primary Bile Duct Cancer and von Recklinghausen DiseaseDIRK P. SPRENGERS, M.D., DANIEL C. KNOCKAERT, M.D., WERNER VAN STEENBERGEN, M.D., FREDDY PENNINCKX, M.D.DIRK P. SPRENGERS, M.D.Search for more papers by this author, DANIEL C. KNOCKAERT, M.D.Search for more papers by this author, WERNER VAN STEENBERGEN, M.D.Search for more papers by this author, FREDDY PENNINCKX, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-772_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The association of neurofibromatosis (von Recklinghausen disease) with malignant tumors of neural crest origin is well documented, but common cancers like colon, lung, and breast cancer are underreported (1, 2). Neurofibromas and neurogenic tumors of the gastrointestinal tract are found in 10% to 25% of patients (3). We report two cases of bile duct cancer, an uncommon type of adenocarcinoma, in patients with neurofibromatosis.A 50-year-old man with known neurofibromatosis was hospitalized because of painless jaundice. His total serum bilirubin level was 23.7 mg/dL, and alkaline phosphatase level 1033 IU/L. Endoscopic retrograde cholangiopancreatography showed hilar obstruction, and...References1. HOPEMULVIHILL DJ. Malignancy in neurofibromatosis. Adv Neurol. 1981;29:33-56. MedlineGoogle Scholar2. SORENSENMUBIRHILLNIELSEN SJA. Long-term follow-up of von Recklinghausen neurofibromatosis: survival and malignant neoplasms. N Engl J Med. 1986;314:1010-5. CrossrefMedlineGoogle Scholar3. HOCHBERSDASILVAGALDABINIRICHARDSON FAJE. Gastrointestinal involvement in von Recklinghausen's neurofibromatosis. Neurology. 1974;24:1144-51. CrossrefMedlineGoogle Scholar4. BOISSONASBUTTINKHALIFA ASP. Tumeur carcinoïdienne vatéro-duodenale et neurofibromatose de Recklinghausen. Ann méd interne. 1985;136:46-8. MedlineGoogle Scholar5. MEYERGRIFFITHSCOHENJOHNSONWEAVER GWLLM. Hepatobiliary involvement in von Recklinghausen's disease. Ann Intern Med. 1982;97:722-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Hospital Gasthuisberg Leuven Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeoplasms Associated with Germline and Somatic NF1 Gene MutationsSegmentally Distributed Neurofibromatosis Associated with Adenocarcinoma of the ColonAmpullary Adenocarcinoma in Neurofibromatosis Type 1. Case Report and Literature ReviewPancreatic cancer and hypercalcemia associated with von Recklinghausen's diseasePlexiform neurofibromatosis of the liver: Case report and review of the literatureAnomalous pancreaticobiliary communication in a neurofibromatosis patientGastrointestinal manifestations of type 1 neurofibromatosis (von Recklinghausen's disease)Multiple Primary NeoplasmsAdenocarcinoma of the Vater's Ampulla and von Recklinghausen DiseaseFRANÇOIS PARAF, M.D., THIERRY POYNARD, M.D., Ph.D., PIERRE BEDOSSA, M.D., FRANCOIS GAYRAL, M.D., SYLVIE NAVEAU, M.D., JEAN-PIERRE PIGNON, M.D., GUY LEMAIGRE, M.D., JEAN-CLAUDE CHAPUT, M.D. 1 May 1987Volume 106, Issue 5Page: 772-772KeywordsBile ductsBilirubinBreast cancerColorectal cancerEndoscopic retrograde cholangiopancreatographyGastrointestinal tractLung and intrathoracic tumorsMalignant tumorsNeurofibromatosis type 1Phosphatases Issue Published: 1 May 1987 PDF downloadLoading ...