tbuckley/cabot-search huggingface dataset:
Significance of Somatic Complaints in Patients Suffering from Psychotic Depression
Authors: D. Jones, S.B. Hall
Journal: Psychotherapy and Psychosomatics (1963)

Research Articles| February 10 2010 Significance of Somatic Complaints in Patients Suffering from Psychotic Depression Subject Area: Psychiatry and Psychology D. Jones; D. Jones Liverpool Search for other works by this author on: This Site PubMed Google Scholar S.B. Hall S.B. Hall Liverpool Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1963) 11 (3-4): 193–199. https://doi.org/10.1159/000285676 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation D. Jones, S.B. Hall; Significance of Somatic Complaints in Patients Suffering from Psychotic Depression. Acta Psychotherapeutica et Psychosomatica 31 December 1963; 11 (3-4): 193–199. https://doi.org/10.1159/000285676 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1963Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Secondary centres should provide neonatal intensive care.
Authors: J F Dossetor, D A Barter, S Rubin
Journal: BMJ (1993)

Radiologists' advice about breast lumps EDITOR,-I write to correct the headline in the news section about the warning on unnecessary x ray examinations.'The advice regarding women with breast lumps is for any age, not just women under 50.It is not new but has been included in the second edition of our booklet of advice for referring clinicians, which is new.2There is no new joint report from the college and the National Radio- logical Protection Board on this topic.The college did, however, issue such a report in 19903: this endorsed the recommendation of the Forrest report on breast screening that it should be reserved for women aged 50-64.4
Quantification of myocardial infarct size by thallium-201 single-photon emission computed tomography: experimental validation in the dog.
Authors: F Prigent, J Maddahi, E V Garcia, Y Satoh, K Van Train, D S Berman
Journal: Circulation (1986)

To evaluate the potential advantages of thallium-201 (201T1) single-photon emission computerized tomography (SPECT) to assess myocardial infarct size in the experimental animal, six normal dogs and 14 dogs with 6 to 8 hr closed-chest coronary occlusion (eight left anterior descending and six left circumflex) were studied. Ten minutes after intravenous administration of 2 mCi of 201T1, 30 projections were obtained over 180 degrees. The dogs were killed and their hearts sliced and stained by triphenyl tetrazolium chloride (TTC). Pathologic infarct size was calculated for each slice and for the entire left ventricular myocardium as percent weight. Tomograms were quantified by automatically generating maximum-count circumferential profiles, which were compared with normal limit profiles derived from the six normal dogs. Tomographic infarct size was defined as the percentage of circumferential points falling below normal for each tomogram. SPECT and TTC infarct size on 71 slices correlated highly (mean +/- SD 27.9 +/- 23.4% and 26.7 +/- 25.3%, respectively; r = .93, p less than .001, SEE = 9.4%). To determine SPECT infarct size as percent total left ventricular myocardial weight, infarct sizes from each slice were added to one another after each was multiplied by a coefficient that reflected the contribution of that slice to the total left ventricular weight. SPECT and TTC infarct size for the entire left ventricle correlated closely (mean +/- SD 20.5 +/- 7.6% and 19.3 +/- 8.3%, respectively; r = .86, p less than .001, SEE = 4.5%). It is concluded that 201T1 SPECT is a valid method for the noninvasive assessment of experimental myocardial infarct size.
Hemodynamics at Rest and during Exercise in Combined Aortic Stenosis and Insufficiency
Authors: PHILIP O. ETTINGER, MARTIN J. FRANK, GILBERT E. LEVINSON
Journal: Circulation (1972)

The effects of exercise in combined aortic stenosis and insufficiency were evaluated in 10 patients by pressure measurements and the measurement of forward (Q F ) and regurgitant (Q R ) flows by simultaneous upstream and downstream sampling using indocyanine green. While heart rate increased, systolic aortic valve pressure gradient (mean, 37 ± 9 mm Hg) did not change. Increased Q F (mean, 4.54 ± 0.34 at rest and 6.89 ± 0.42 liters/min with exercise, P &lt; 0.001) was balanced by decreased Q R (means, 4.09 ± 1.02 and 2.33 ± 0.71 liters/min, P &lt; 0.02), and total flow did not change significantly. Although diastolic regurgitant period declined, total diastolic seconds per minute decreased by only 6%, while calculated systemic resistance decreased by 30%. Left ventricular systolic and aortic pressures increased, while left ventricular end-diastolic pressure and diastolic aortic valve gradients were unchanged. Mean systolic aortic valve area, calculated by utilizing total valve flow, was 1.8 ± 0.3 cm 2 in both states. Thus, exercise reduces regurgitant fraction in mixed aortic lesions as in pure aortic insufficiency. This observation confirms the necessity of measuring total valve flow in evaluation of mixed valve lesions. Reduced regurgitation primarily reflects an altered relationship of peripheral resistance to backflow resistance. While the stenotic valve is demonstrated to behave as a fixed systolic orifice, the diastolic aortic orifice area cannot be calculated from the Gorlin equation as it does not account for peripheral resistance.
Book Review Cerebrovascular Disease Edited by H. Hunt Batjer, with Louis R. Caplan, Lars Friberg, Ralph G. Greenlee, Jr., Thomas A. Kopitnik, Jr., and William L. Young. 1276 pp., illustrated. Philadelphia, Lippincott–Raven, 1997. $275. 0-397-51661-4
Authors: Dennis W. Choi
Journal: New England Journal of Medicine (1998)
Virchowʼs Node on F-18 FDG PET/CT
Authors: Daniel Cham, Robert Henderson, Peter S. Conti
Journal: Clinical Nuclear Medicine (2004)

Virchow's node is a solitary supraclavicular adenopathy, most commonly found on the left side. It is usually palpable and is associated with metastases from squamous cell carcinoma of the head and neck, primary lung cancer, esophageal cancer, or cancer of the uterine cervix. When undifferentiated tissue is found, lymphoma is also included in the differential diagnostic list. Whole-body F-18 FDG scintigraphy was performed for staging in a 56-year-old man with recent diagnosis of esophageal carcinoma. Previous CT demonstrated an abnormality in the distal esophagus and normal-size lymph nodes near the gastroesophageal junction. PET scintigraphy was done in conjunction with CT attenuation correction of multiple axial views of the chest, abdomen, and pelvis. The scintigraphic pattern showed a large primary carcinoma of the mid to distal esophagus above the level of the gastroesophageal junction, two normal-size right retrocrural nodes, and left supraclavicular adenopathy.
17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry
Authors: James H. Flory, Patrick M. Sleiman, Jason D. Christie, Kiran Annaiah, Jonathan Bradfield, Cecilia E. Kim, Joseph Glessner, Marcin Imielinski, Hongzhe Li, Edward C. Frackelton, Hou Cuiping, George Otieno, Kelly Thomas, Ryan Smith, Wendy Glaberson, Maria Garris, Rosetta Chiavacci, Julian Allen, Jonathan Spergel, Robert Grundmeier, Michael Grunstein, Michael Magnusson, Struan F.A. Grant, Klaus Bønnelykke, Hans Bisgaard, Hakon Hakonarson
Journal: Journal of Allergy and Clinical Immunology (2009)
On the Protection from Waterborne Disease Afforded by the Pasteur-Chamberland and Berkefeld Filters
Authors: W. H. Horrocks
Journal: BMJ (1901)

MAN.Y investigations have been made with the object of ascer- taining the extent and duration of the protection from water- borne disease afforded by the Pasteur-Chamberland and Berkefeld:filters.Experiments soon showed that the direct passage of micro-organisms through the candles of tllese filters, consequent on some flaw in the material or imperfec- tion in the fittings, must be distinguished from the indirect passage of bacteria, consequent on the gradual growth of the organisms through the lacunar spaces of the filter material.The direct passage is easily tested by means of some colour- producing organism, such as the B. prodigiosus, and all the experiments made with Pasteur-Chamberland and Berkefeld filters show that the direct passage of bacteria is prevented, provided the flow through the candles is steady and con- tinuous.If the flow be intermittent, there appear -to be strong reasons for believing that with each action of an attached pump the direct passage of micro-organisms will take place.This intermittent action is easily obviated by introducing an air chamber between the pump and the filter- ing candle.The indirect passage of pathogenic and non-patho- genic micro-organisms through the Pasteur-Chamber- land and Berkefeld candles has been the subject of much
Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation.
Authors: G Q Jia, J A Gonzalo, C Lloyd, L Kremer, L Lu, C Martinez-A, B K Wershil, J C Gutierrez-Ramos
Journal: The Journal of Experimental Medicine (1996)

We have cloned a novel mouse CC chemokine cDNA from the lung during an allergic inflammatory reaction. The protein encoded by this cDNA is chemotactic for eosinophils, monocytes, and lymphocytes in vitro and in vivo. Based on its similarities in sequence and function with other CC chemokines, we have named it mouse monocyte chemotactic protein-5 (mMCP-5). Under noninflammatory conditions, expression of mMCP-5 in the lymph nodes and thymus is constitutive and is generally restricted to stromal cells. Neutralization of mMCP-5 protein with specific antibodies during an allergic inflammatory reaction in vivo resulted in a reduction in the number of eosinophils that accumulated in the lung. Moreover, mMCP-5 mRNA expression in vivo is regulated differently from that of other major CC chemokines in the lung during the allergic reaction, including Eotaxin. The presence of lymphocytes is essential for expression of mMCP-5 by alveolar macrophages and smooth muscle cells in the lung, and the induction of mMCP-5 RNA occurs earlier than that of the eosinophil chemokine Eotaxin during allergic inflammation. In contrast to Eotaxin, mRNA for mMCP-5 can be produced by mast cells. From these results, we postulate that mMCP-5 plays a pivotal role during the early stages of allergic lung inflammation.
Three puzzling cases
Authors: George Dunea
Journal: BMJ (2004)

The clinicopathological conference is a time honoured exercise in which a participant is given a clinical protocol and tries to make a diagnosis. It has been variously lauded as an instructive teaching exercise or derided as an unreal situation.

The cases are often puzzling. What, for example, is one to make of a wasted man, deathly pale, with web-like thin hair, exaggerated sensitivity to noise, odours, light, or touch, where the course of the …
Production of Two Distinct and Independent Hepatic Immunoregulatory Molecules by the Perfused Rat Liver
Authors: Francis V. Chisari, Mary Nakamura, David R. Milich, Keith Han, Daniel Molden, Geert G. Leroux-Roels
Journal: Hepatology (1985)

By manipulating dietary sugar intake and perfusate glucose concentration, we have identified two independent hepatic immunoregulatory molecules produced by the perfused rat liver. The first is released by injured hepatocytes, appears in perfusates together with hepatocellular glutamic pyruvic transaminase, is quantitatively inhibited by exogenous L-arginine and coelutes with arginase on high-pressure liquid chromatography. Based on these findings, we conclude that this activity is due to the release of cytoplasmic arginase from injured hepatocytes. Since supplementation studies reveal that lymphocyte proliferation is exquisitely arginine-dependent, it is conceivable that arginase released by injured hepatocytes might influence lymphocyte function in vivo by local arginine depletion. The second immunoregulatory molecule is released by noninjured hepatocytes following induction by sugar, particularly glucose, both in vivo or in vitro. This inducible activity is arginase-independent, triglyceride-rich and floats at a density less than 1.006 gm per ml upon ultracentrifugation. Based on these characteristics, we tentatively ascribe this activity to hepatic very low density lipoprotein, the serum counterpart of which is known to express many immunoregulatory properties. These results directly illustrate for the first time the pathophysiological conditions required for the secretion and release of these distinct and independent hepatic immunoregulatory molecules, and they suggest possible routes by which they may influence immunological homeostasis and immunologically mediated liver disease.
Abstract 1422: Interleukin-17A activates tumor progression locus 2 to induce neoplastic cell transformation and breast carcinogenesis.
Authors: Garam Kim, Hong Seok Choi
Journal: Cancer Research (2013)

Abstract Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated CD4+ memory T cells. Although the role of T cells in cancer promotion has been examined, little is known about the underlying molecular mechanisms of interleukin-17 A (IL-17A) in carcinogenesis. In the present study, we first found that IL-17A induces neoplastic transformation of JB6 Cl41 cells through activation of tumor progression locus 2 (TPL2). IL-17A activates MEKs-ERKs, JNKs-c-Jun, and STAT3 signaling pathways, which are inhibited by a TPL2 kinase inhibitor (TKI). Furthermore, IL-17A activates c-fos and c-jun promoter activity, resulting in increased activator protein-1 (AP-1) activity. When small interfering RNA (siRNA) of IL-17A receptor (IL-17R), IL-17A, and TPL2 were introduced into JB6 Cl41 cells, respectively, IL-17A-induced AP-1 activity was significantly decreased compared to control cells. Similarly, TPL2 inhibition suppressed AP-1 activity induced by IL-17A. The knockdown of IL-17R and TKI treatment in JB6 Cl41 cells resulted in decreased IL-17A-induced cell transformation. The in vivo chorioallantoic membrane (CAM) assay also showed that IL-17A increased tumor formation of JB6 Cl41 cells, whereas TKI inhibited the tumorigenesis promoted by IL-17A. Consistent with these observations, knockdown of IL-17A and/or inhibition of TPL2 attenuated tumorigenecity of human breast cancer MCF7 cells. Moreover, immunohistochemical staining showed that both expressions of IL-17A and TPL2 were highly upregulated in human breast cancers. Together, our findings point to a critical role for the IL-17A-induced TPL2 signaling pathway in supporting cancer-associated inflammation in the tumor microenvironment. Therapeutic approaches that target this pathway may therefore effectively inhibit carcinogenesis. Citation Format: Garam Kim, Hong Seok Choi. Interleukin-17A activates tumor progression locus 2 to induce neoplastic cell transformation and breast carcinogenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1422. doi:10.1158/1538-7445.AM2013-1422 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Children have rights to medicines
Authors: C. Essex, G. Rylance
Journal: BMJ (1997)

Editor—If a medicine was restricted to certain racial groups or to one sex on the basis of information from studies limited to these groups there would be an understandable outcry. Yet one group of the population—children—is denied access to treatment on this basis. This unacceptable situation persists because children have no vote, no spending power, and little voice. John Warden's article on the report by the …
Epidemiology of chickenpox in England and Wales, 1967-85
Authors: C. A Joseph, N. D Noah
Journal: BMJ (1988)

Routine sources of data on chickenpox morbidity and mortality in England and Wales were reviewed for 1967-85. Only two epidemics occurred, one in 1967 and one in 1980, both of which were immediately followed by two to three years of low incidence. The age distribution of the disease appears to be changing, with more cases now being reported in children aged 0-4 years. The number of deaths in adults have, however, increased, particularly those deaths that are associated with pneumonia and immunosuppression. At present in England and Wales more deaths are attributed to chickenpox than to whooping cough and mumps. Widespread use of selective immunisation against chickenpox might be justified in England and Wales, but before routine immunisation of the child population can be considered special surveys to determine the incidence and severity of chickenpox and the effect of the vaccine on the subsequent development of herpes zoster are needed as well as cost-benefit studies of immunisation.
Ibutilide, a Methanesulfonanilide Antiarrhythmic, Is a Potent Blocker of the Rapidly Activating Delayed Rectifier K <sup>+</sup> Current (I <sub>Kr</sub> ) in AT-1 Cells
Authors: Tao Yang, Dirk J. Snyders, Dan M. Roden
Journal: Circulation (1995)

Ibutilide is an action potential-prolonging antiarrhythmic currently in clinical trials. The drug shares structural similarities with E-4031 and dofetilide, specific blockers of the rapidly activating delayed rectifier K+ current (IKr). However, previous in vitro studies in guinea pig myocytes have indicated that ibutilide does not block IKr but rather increases a slow inward sodium current.In this study, we compared the effects of ibutilide with those of dofetilide on outward current in mouse atrial tumor myocytes (AT-1 cells), a preparation in which, unlike guinea pig, a typical IKr is the major delayed rectifier and can be readily recorded in isolation from other currents. In AT-1 cells, ibutilide and dofetilide were both potent IKr blockers, with EC50 values of 20 (n = 12) and 12 (n = 8) nmol/L, respectively, at +20 mV. The time and voltage dependence of IKr inhibition by the two compounds were virtually identical. The following characteristics were most consistent with open channel block: (1) block increased with depolarizing pulses; (2) block increased with longer pulses; (3) currents deactivated more slowly in the presence of drug, resulting in a "crossover" typical of open channel block; and (4) with repetitive pulsing after drug wash-in, use-dependent block was observed.These data suggest that the clinical actions of ibutilide are mediated at least in part by block of IKr; an effect on inward currents is not excluded. AT-1 cells are a useful model system for the study of drug block of this important repolarizing current.
Graftskin, a Human Skin Equivalent, Is Effective in the Management of Noninfected Neuropathic Diabetic Foot Ulcers
Authors: Aristidis Veves, Vincent Falanga, David G. Armstrong, Michael L. Sabolinski
Journal: Diabetes Care (2001)

OBJECTIVE— We assessed in a randomized prospective trial the effectiveness of Graftskin, a living skin equivalent, in treating noninfected nonischemic chronic plantar diabetic foot ulcers. RESEARCH DESIGN AND METHODS— In 24 centers in the U.S., 208 patients were randomly assigned to ulcer treatment either with Graftskin (112 patients) or saline-moistened gauze (96 patients, control group). Standard state-of-the-art adjunctive therapy, which included extensive surgical debridement and adequate foot off-loading, was provided in both groups. Graftskin was applied at the beginning of the study and weekly thereafter for a maximum of 4 weeks (maximum of five applications) or earlier if complete healing occurred. The major outcome of complete wound healing was assessed by intention to treat at the 12-week follow-up visit. RESULTS— At the 12-week follow-up visit, 63 (56%)Graftskin-treated patients achieved complete wound healing compared with 36(38%) in the control group (P = 0.0042). The Kaplan-Meier median time to complete closure was 65 days for Graftskin, significantly lower than the 90 days observed in the control group (P = 0.0026). The odds ratio for complete healing for a Graftskin-treated ulcer compared with a control-treated ulcer was 2.14 (95% CI 1.23-3.74). The rate of adverse reactions was similar between the two groups with the exception of osteomyelitis and lower-limb amputations, both of which were less frequent in the Graftskin group. CONCLUSIONS— Application of Graftskin for a maximum of 4 weeks results in a higher healing rate when compared with state-of-the-art currently available treatment and is not associated with any significant side effects. Graftskin may be a very useful adjunct for the management of diabetic foot ulcers that are resistant to the currently available standard of care.