tbuckley/cabot-search huggingface dataset:
Remarques sur un groupe Balint fonctionnant depuis cinq ans
Authors: G. Besançon, C. Ganry, G. de la Rochefordière
Journal: Psychotherapy and Psychosomatics (1972)

This is a record of the operating of the Nantes Balint group in 1964. After calling to mind a historical account of the group, the authors call forth the dynamics of a group meeting: a new case being brought to light or an already known case; is a long pause followed with diffused questions put to the leaders; opened in a self-assertive style by the drawing of names. A brief survey then takes place about the varied attitude of the group Doctors, the crisis undergone, the ensuing modifications (particularly after one of the leaders departure), and the problem of a psychoanalyst being present or not in such a group.
Decreased human epidermal antigen-presenting cell activity after ultraviolet A exposure: dose–response effects and protection by sunscreens
Authors: P.E. Stoebner, R. Poosti, K. Djoukelfit, J. Martinez, L. Meunier
Journal: British Journal of Dermatology (2007)

Ultraviolet (UV) exposure of human skin causes immunosuppression that contributes to the growth of skin cancer. The contribution of UVA in these processes is still a matter of debate.The purpose of our study was first to find a dose-response effect of UVA exposure on human epidermal antigen-presenting cell (APC) activity and to evaluate the protective capacity of two sunscreen formulations against a high level of acute UVA exposure. We also tried to evaluate the protective capacity afforded by the same sunscreens against UVA-induced clinical changes such as redness and pigmentation.The functional assessment of the alloantigen-presenting capacity of epidermal cells prepared from skin keratotome samples 3 days after UVA exposure was measured with a mixed epidermal cell-lymphocyte reaction (MECLR) in each healthy volunteer (n = 16). Redness and pigmentation were assessed by chromametry 24 h after exposure to a single UVA dose.In vivo UVA exposure to 15, 30 and 60 J cm(-2) resulted in a dose-dependent decrease in purified allogeneic T cell (CD4+ T cells) proliferation induced by UVA-irradiated epidermal cells. The epidermal APC function was significantly decreased with a suberythemal exposure corresponding to 15 J cm(-2). The decrease, partial and not statistically different between 30 and 60 J cm(-2), exhibits a plateau-response effect. There was no correlation between the decrease of the epidermal APC function and the intensity of erythema and persistent pigment darkening. Both sunscreen formulations strongly inhibited the UVA-induced reduction of MECLR at 90 J cm(-2).Our results clearly demonstrate that UVA impairs the APC activity of the epidermal cells and thus may contribute to UV-induced immunosuppression in humans. They also indicate that erythema and immunosuppression have different dose-response curves in the UVA range. The two sunscreen formulations afforded a significant protection against the decrease in epidermal APC activity induced by exposure to a high UVA dose (90 J cm(-2)).
Human multiple organ-reactive monoclonal autoantibody recognizes growth hormone and a 35,000-molecular weight protein.
Authors: J Satoh, K Essani, P R McClintock, A L Notkins
Journal: Journal of Clinical Investigation (1984)

By fusing peripheral leukocytes from a patient with insulin-dependent diabetes with mouse myeloma cells, a heterohybridoma was isolated that, for over one year, has secreted a human monoclonal autoantibody, designated MOR-h1 (multiple organ-reactive human 1). This antibody reacts with antigens in several endocrine organs including the pituitary, thyroid, stomach, and pancreas. By double immunofluorescence, MOR-h1 was found to react specifically with growth hormone (GH)-containing cells in the anterior pituitary and, by enzyme-linked immunosorbent assay, MOR-h1 was shown to react with both natural and biosynthetic GH. Absorption experiments revealed that GH could remove the capacity of MOR-h1 to react not only with cells in the anterior pituitary, but also with cells in the thyroid, stomach, and pancreas. The demonstration with hyperimmune serum that these organs do not contain GH indicated that MOR-h1 was reacting with a different molecule(s) in these organs. By passing extracts of pituitary, thyroid, and stomach through an MOR-h1 affinity column and analyzing the eluted antigens by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, a 35,000-mol wt polypeptide was isolated from each of these organs. In addition, a 21,500-mol wt polypeptide with an electrophoretic mobility identical to purified human GH was isolated from the pituitary, but not the other organs. It is concluded that MOR-h1 reacts with a 35,000-mol wt polypeptide present in the pituitary, thyroid, and stomach and that this antibody also recognizes a determinant on GH.
Anesthesia for the Uninterested
Authors: J. S. Gravenstein
Journal: JAMA (1976)

This is a good book. This is a bad book. And the good and bad aspects interact in a perplexing way. Birch and Tolmie set out to write for medical students a brief and readable introduction to anesthesia. They cover such mundane areas as how to start an IV, how to monitor vital signs, how to adjust an operating room table, and how to protect a patient on the table against nerve palsies. They even mention practice arrangements and malpractice problems. They also provide brief and sometimes breezy accounts of acidbase balance and ventilators, in addition to the obvious subjects for a primer in anesthesia. All that is good. There is no book that does not contain some errors, nor is there a reviewer who could not find an example of misplaced emphasis. I won't mention these because the biggest questions the book raises lie elsewhere. In their attempt to
Evaluation continues of "HBO' clinical uses
Authors: P. Gunby
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Statin Use After Colorectal Cancer Diagnosis and Survival: A Population-Based Cohort Study
Authors: Chris R. Cardwell, Blanaid M. Hicks, Carmel Hughes, Liam J. Murray
Journal: Journal of Clinical Oncology (2014)

To investigate whether statins used after colorectal cancer diagnosis reduce the risk of colorectal cancer-specific mortality in a cohort of patients with colorectal cancer.A cohort of 7,657 patients with newly diagnosed stage I to III colorectal cancer were identified from 1998 to 2009 from the National Cancer Data Repository (comprising English cancer registry data). This cohort was linked to the United Kingdom Clinical Practice Research Datalink, which provided prescription records, and to mortality data from the Office of National Statistics (up to 2012) to identify 1,647 colorectal cancer-specific deaths. Time-dependent Cox regression models were used to calculate hazard ratios (HR) for cancer-specific mortality and 95% CIs by postdiagnostic statin use and to adjust these HRs for potential confounders.Overall, statin use after a diagnosis of colorectal cancer was associated with reduced colorectal cancer-specific mortality (fully adjusted HR, 0.71; 95% CI, 0.61 to 0.84). A dose-response association was apparent; for example, a more marked reduction was apparent in colorectal cancer patients using statins for more than 1 year (adjusted HR, 0.64; 95% CI, 0.53 to 0.79). A reduction in all-cause mortality was also apparent in statin users after colorectal cancer diagnosis (fully adjusted HR, 0.75; 95% CI, 0.66 to 0.84).In this large population-based cohort, statin use after diagnosis of colorectal cancer was associated with longer rates of survival.
VALUE OF CALMETTE VACCINATION IN PREVENTION OF TUBERCULOSIS IN CHILDHOOD
Authors: ARVID WALLGREN
Journal: JAMA (1934)

In a critical survey of the reports on experimental vaccination on human beings I attempted in 1926 to draw up some principles for carrying out an anti-tuberculous vaccination. Tentatively I began working along these lines and as the experiment seemed to turn out well I have continued along the path struck. In 1928 I published inThe Journala preliminary account of my experiments, 1 and I now submit the results achieved up to the present.  The history of the production of the B C G vaccine is no doubt well known and I shall therefore content myself with mentioning that the vaccine is composed of an originally virulent strain of bovine tubercle bacilli, which by means of certain methods of cultivation has been made very nearly avirulent. To be approved, a vaccine of this kind should fulfil at least these two primary conditions: It should be free from any
Every hospital must improve in-hospital resuscitation
Authors: V M K Bhaskarabhatla
Journal: BMJ (1999)

EDITOR—Timely and properly performed cardiopulmonary resuscitation and defibrillation save many lives.1 The first few moments and minutes are all-important.

Prehospital cardiac care is increasingly being used, and improvements must now be made to in-hospital cardiopulmonary resuscitation. Health care in hospitals is being increasingly compartmentalised, but provision of cardiopulmonary resuscitation should …
Renal Pseudotumor Due to Infolding Column of Bertin
Authors: Myo M. Kyaw
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In spite of a few welldocumented reports in the literature on this recently popularized entity of renal pseudotumors,<sup>1-5</sup>the one due to the infolding renal column of Bertin is still not widely known. Consequently, patients have been subjected to unnecessary surgical procedures for this innocent apparent renal mass lesion.<sup>1,3</sup>Although the pyelographic appearance may suggest a mass in the kidney, the diagnosis of pseudotumor consisting of normal renal parenchyma can be easily established by renal angiogram. Obviously, awareness and recognition of pseudotumor due to infolding renal column is extremely important, so that the apparent mass consisting of normal parenchymal tissues is not mistakenly diagnosed as neoplasm. <h3>Report of a case.—</h3> This is a 22-year-old man who was found to be hypertensive during routine physical examination. The patient was completely asymptomatic and particularly denied having any symptoms referrable to the genitourinary system. The past history was
The differential effects of positive inotropic and vasodilator therapy on diastolic properties in patients with congestive cardiomyopathy.
Authors: J D Carroll, R M Lang, A L Neumann, K M Borow, S I Rajfer
Journal: Circulation (1986)

Symptoms of congestive heart failure frequently reflect abnormalities in both systolic and diastolic performance. While much work has been reported regarding the mechanisms by which positive inotropic and vasodilator therapy affect systolic performance, little is known about their effect on diastolic function. In 12 patients with diffuse congestive cardiomyopathy micromanometer left ventricular and aortic pressure measurements were recorded simultaneously with two-dimensionally targeted M mode echocardiograms and thermodilution-determined cardiac output. Each patient received dopamine (2, 4, and 6 micrograms/kg/min), and dobutamine (2, 6, and 10 micrograms/kg/min), and 10 received nitroprusside (0.125 to 2.0 micrograms/kg/min). Baseline hemodynamics were characterized by low cardiac index (2.1 +/- 0.7 liter/min/m2, mean +/- SD), high left ventricular end-diastolic pressure (24 +/- 10 mm Hg), and increased end-diastolic (6.8 +/- 1.0 cm) and end-systolic dimensions (6.0 +/- 1.0 cm). All patients had abnormal left ventricular pressure decay with a prolonged time constant (67 +/- 20 msec) and reduced peak diastolic lengthening rates. Dopamine and dobutamine decreased the time constant of relaxation and increased the peak lengthening rate. Dobutamine also reduced the minimum diastolic pressure from 14 +/- 7 to 10 +/- 9 mm Hg (p less than .01); neither drug reduced end-diastolic pressure. In fact, dopamine elevated end-diastolic pressures in seven patients, despite more rapid pressure decay. Diastolic pressure-dimension relations after dopamine and dobutamine showed a leftward shift with a reduced end-systolic chamber size, but no significant changes in passive chamber stiffness. Nitroprusside decreased left ventricular minimum diastolic pressure by 4 +/- 2 mm Hg and end-diastolic pressure by 7 +/- 4 mm Hg (p less than .01). It did not consistently accelerate left ventricular pressure decay at the doses tested. The decreased end-diastolic pressure with nitroprusside was due to a reduced end-diastolic dimension in five patients. In the other patients, all of whom had elevated right atrial pressures, diastolic pressure-dimension relations showed a parallel downward shift after nitroprusside. Thus, positive inotropic therapy with beta 1-adrenoceptor agonists enhances early diastolic distensibility by accelerating relaxation, augmenting filling, and reducing end-systolic chamber size. Vasodilator therapy is much more effective in lowering diastolic pressures.(ABSTRACT TRUNCATED AT 400 WORDS)
Metformin: framed again?
Authors: D. J Preiss, N. Sattar
Journal: BMJ (2009)

Fitzgerald and colleagues show that metformin treatment should be avoided in acute renal failure,1 but their focus on metformin associated lactic acidosis is misplaced.

Metformin has long been suggested as a cause of lactic acidosis in published case reports, but evidence from large cohorts and meta-analyses of controlled trials remains conspicuously absent.2 Metformin is often …
But the Patient Died
Authors: John B. Stetson
Journal: JAMA (1964)

British hospitals, like those in this country, are similar to isolated villages, if we think in terms of the close and constant contact of staff members. St. Justin's Hospital (imaginary) is no exception. Geoffrey Tremaine arrives to begin his new appointment as surgical registrar in time to find Everard Nicholson, the senior administrator, on the floor of his office in a coma. Nicholson (well-hated by most of the people at St. Justin's) goes on to die after the successful removal of a brain tumor. The stage is set for an excellent "who-done-it." The specialists and hospital personalities are all there. The author's information about hospital life indicates extensive research (or good advice, or both); the character sketches of the specialists reminds us painfully of people we have met. All in all,<i>But the Patient Died</i>, will entertain any physician; those who enjoy mysteries will probably finish it at one sitting.
The CCU and Mortality
Authors: OSLER L. PETERSON
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 March 1972The CCU and MortalityOSLER L. PETERSON, M.D., BENEDICT J. DUFFY, M.D.OSLER L. PETERSON, M.D.Search for more papers by this author, BENEDICT J. DUFFY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-3-510 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The following statement by Moss and colleagues (1) in the December issue raises a seriously neglected question.Since the introduction of coronary care units, the reduced mortality from acute myocardial infarction is primarily owing to the prevention and prompt treatment of electrical instability of the cardiac rhythm. Although coronary care units have lowered the in-hospital mortality of acute coronary disease to about 15%. . . .The question relates to the evidence upon which the widely accepted assumption about the benefits of these units is based.Many of the clinical reports purporting to demonstrate the benefit of...References1. MOSS A, SCHNITZLER R, and GREEN R: Ventricular arrhythmias weeks after acute myocardial infarction. Ann Intern Med 75:837-841, 1971 LinkGoogle Scholar2. : Leading Component of Upturn in Mortality, U.S. 1952-67. Series 20, No. 11, DHEW Publication No. 72-1008 Google Scholar3. MATHER N, PEARSON N, and REED K: Acute myocardial infarction: home and hospital treatment. Br Med J 3:334-338, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: OSLER L. PETERSON, M.D.; BENEDICT J. DUFFY, M.D.Affiliations: Tufts University School of Medicine Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTechnology in Medicine 1 March 1972Volume 76, Issue 3Page: 510-511KeywordsAcute myocardial infarctionCardiac care unitMortality ePublished: 1 December 2008 Issue Published: 1 March 1972 PDF downloadLoading ...
In Search of Equipoise
Authors: Vineet Chopra
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic biliary stenting in a district general hospital.
Authors: K J Rao, N M Varghese, H Blake, A Theodossi
Journal: Gut (1995)

During a 48 month period to December 1990, 367 patients, median age 75 years, with obstructive jaundice caused by common bile duct stones (201), malignant biliary obstruction (148), and benign biliary strictures (18), underwent therapeutic endoscopic retrograde cholangiopancreatography. Endoscopic biliary stenting and drainage was achieved in 343 of 367 patients attempted (93%), seven patients requiring a combined percutaneous endoscopic approach. Endoscopic stenting failed in 24 patients because of malignant duodenal infiltration (10), Billroth 2 gastrectomy (6), tight and extensive biliary strictures (6), peripapillary diverticulum (1), and technical failure (1). Prolonged follow up was available in 91% (311 of 343). The 30 day mortality was 5% (17 of 343), which included two procedure related deaths (0.6%) from fulminant pancreatitis and major sphincterotomy site bleeding. Early complications occurred in 14% (48 of 343) and late complications occurred in 11.9% (35 of 294) patients, as of the original 343, 17 had died within 30 days and another 32 were lost to follow up. Eighty patients with incomplete bile duct clearance and eight patients with benign biliary strictures had biliary stents inserted for 12-48 months (median 30). Endoscopic biliary stenting services are necessary in a district general hospital with technical success, death and morbidity rates comparable to other studies.
Intra-articular distension and steroids in the management of capsulitis of the shoulder.
Authors: L G Jacobs, M A Barton, W A Wallace, J Ferrousis, N A Dunn, D H Bossingham
Journal: BMJ (1991)

OBJECTIVE--To determine whether there is any synergistic effect in the administration of intraarticular steroids with distension in the management of early capsulitis of the shoulder. DESIGN--Prospective randomised trial of three treatments--namely distension only, steroid only, and steroid with distension. SETTING--Academic department of orthopaedic and accident surgery at Queen9s Medical Centre, Nottingham. SUBJECTS--47 patients (30 women) with capsulitis affecting 50 shoulders. INTERVENTIONS--Three intra-articular injections into the shoulder given at six week intervals by the same technique. MAIN OUTCOME MEASURES--Passive range of abduction, forward flexion, and external rotation; results of shoulder dynamometry measuring work done and torque produced; pain levels at rest and with resisted movement. RESULTS--All patients reported improvement during the study. Analysis of the mean improvements in abduction and forward flexion showed these to be significantly greater in the steroid with distension and steroid only groups than in the distension only group (mean improvements in abduction (degrees/week (95% confidence interval)) 4.3 (3.4 to 5.2), 3.4 (2.4 to 4.5), and 1.0 (-0.8 to 2.8) in the three groups respectively; mean improvements in flexion (degrees/week (95% confidence interval)) 3.6 (3.2 to 4.0), 3.3 (2.3 to 4.3), and 1.5 (0.5 to 2.5) respectively). Shoulder dynamometry failed to show a significant difference among the treatment groups. No severe complications occurred as a result of the injections, but two patients reported facial flushing related to the use of steroids. CONCLUSION--Intra-articular steroid injections have a useful role in the outpatient management of early capsulitis.
Possible involvement of copper(II) in Alzheimer disease.
Authors: Teresa Kowalik-Jankowska, Monika Ruta-Dolejsz, Kornelia Wisniewska, Leszek Lankiewicz, Henryk Kozlowski
Journal: Environmental Health Perspectives (2002)

The beta-amyloid (Abeta) peptide is a principal component of insoluble amyloid plaques that are characteristic neuropathological features of Alzheimer disease (AD). The amyloid peptide also exists as a normal soluble protein that undergoes a pathogenic transition to an aggregated, fibrous form. This transition can be affected by extraneous proteinaceous elements and nonproteinaceous elements such as copper ions, which may promote aggregation and/or stabilization of the fibrils. Copper has been found in abnormally high concentrations in amyloid plaques and AD-affected neuropil, and copper-selective chelators have been shown to dissolve Abeta peptide from postmortem brain specimens. Although Cu(2+) is an essential element for life and the function of numerous enzymes is basic to neurobiology, free or incorrectly bound Cu(2+) can also catalyze generation of the most damaging radicals, such as hydroxyl radical, giving a chemical modification of the protein, alternations in protein structure and solubility, and oxidative damage to surrounding tissue.