tbuckley/cabot-search huggingface dataset:
Identification of congenital malformations of the great arteries in infants by real-time two-dimensional echocardiography.
Authors: B J Maron, W L Henry, J M Griffith, R M Freedom, D T Kelly, S E Epstein
Journal: Circulation (1975)

Real-time, two dimensional echocardiography was used to identify great artery relations in 23 infants and small children, including 16 patients with angiography documented transposition of the great arteries, tetralogy of Fallot, or pulmonary aresia. Using this technique, the heart was scanned perpendicular to its long axis at the origin of the great arteries. Great arteries cross-sectioned perpendicular to their long axes appear as circles; when sectioned longitudinally these arteries appeared as elongated sausage-shaped structures. I- patients with normally related great arteries, a curcular structure (aorta) always was positioned posterior to an elongated, sausage-shaped structure (distal right ventricular outflow tract and proximal main pulmonary artery). In transposition of the great arteries, two adjacent circular structures were observed; the anterior circle (aorta) was located to the right, left or directly anterior to the posterior circle (pulmonary artery). In pulmonary atresia or hypoplasis, a large posterior circle (aorta) was associated with an anteriorly positioned structure that was either short and small (atretic right ventricular outflow tract) or elongated with an area of severe narrowing (hypoplastic right ventricular outflow tract). Thus, real-time two-dimensional echocardiography provides a rapid, noninvasive means of accurately identifying congenital malformations of the great arteries in infants and small children and may be a useful adjunct to cardiac catheterization in the diagnosis of cyanotic congenital heart disease.
Suspect endocrine disorder in cases of severe adult acne
Authors: E. Pease
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correlation Between Arterial FDG Uptake and Biomarkers in Peripheral Artery Disease
Authors: Kelly S. Myers, James H.F. Rudd, Eric P. Hailman, James A. Bolognese, Joanne Burke, Cathy Anne Pinto, Michael Klimas, Richard Hargreaves, Hayes M. Dansky, Zahi A. Fayad
Journal: JACC. Cardiovascular imaging (2012)
907 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH ELEVATED SERUM VIRAL LOAD OF HEPATITIS B VIRUS IN PATIENTS WITH CHRONIC HEPATITIS B: A GENOME-WIDE ASSOCIATION STUDY IN TAIWAN
Authors: H.-I. Yang, Y.-C. Chien, T.-N. Ho, C.-L. Jen, C.-Y. Lee, Y.R. Lin, M.-H. Lee, J. Liu, C.-H. Chen, C.-J. Chen
Journal: Journal of Hepatology (2011)
Prescriber's narcophobia syndrome: physicians' disease and patients' misfortune
Authors: B. D Veysman
Journal: BMJ (2009)

<h3>Background and problem</h3> The WHO Surgical Safety Checklist has been shown to improve patient safety as well as improving teamwork and communication in theatres. In 2009, it was made a mandatory requirement for all NHS hospitals in England and Wales. The WHO checklist is intended to be adapted to suit local settings and was modified for use in Gloucestershire Hospitals NHS Foundation Trust. In 2018, it was decided to review the use of the adapted WHO checklist and determine whether improvements in compliance and engagement could be achieved. <h3>Aim</h3> The aim was to achieve 90% compliance and engagement with the WHO Surgical Safety Checklist by April 2019. <h3>Methods</h3> In April 2018, a prospective observational audit and online survey took place. The results showed compliance for the ‘Sign In’ section of the checklist was 55% and for the ‘Time Out’ section was 91%. Engagement by the entire theatre team was measured at 58%. It was proposed to move from a paper checklist to a wall-mounted checklist, to review and refine the items in the checklist and to change the timing of ‘Time Out’ to ensure it was done immediately prior to knife-to-skin. <h3>Results</h3> Following its introduction in September 2018, the new wall-mounted checklist was reaudited. Compliance improved to 91% for ‘Sign In’ and to 94% for ‘Time Out’. Engagement by the entire theatre team was achieved 100% of the time. Feedback was collected, adjustments made and the new checklist was rolled out in stages across all theatres. A reaudit in December 2018 showed compliance improved further, to 99% with ‘Sign In’ and to 100% with ‘Time Out’. Engagement was maintained at 100%. <h3>Conclusions</h3> The aim of the project was met and exceeded. Since April 2019, the new checklist is being used across all theatres in the Trust.
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death
Authors: Carl G Feng, Lixin Zheng, Dragana Jankovic, André Báfica, Jennifer L Cannons, Wendy T Watford, Damien Chaussabel, Sara Hieny, Patricia Caspar, Pamela L Schwartzberg, Michael J Lenardo, Alan Sher
Journal: Nature Immunology (2008)
The prognosis of patients with alcoholic liver disease. An international randomized, placebo-controlled trial on the effect of malotilate on survival
Authors: Susanne Keiding, Jens H. Badsberg, Ulrik Becker, Kirsten D. Bentsen, Olaf Bonnevie, Joan Caballeria, Jan Eriksen, Finn Hardt, Niels Keiding, Marsha Morgan, Hemming Poulsen, Leo Ranek, Joan Rodés, Geert Schou, Robert Walker, Niels Tygstrup
Journal: Journal of Hepatology (1994)
Blocking <i>Scn10a</i> Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic
Authors: Tao Yang, Thomas C. Atack, Dina Myers Stroud, Wei Zhang, Lynn Hall, Dan M. Roden
Journal: Circulation Research (2012)

Rationale: Although the sodium channel locus SCN10A has been implicated by genome-wide association studies as a modulator of cardiac electrophysiology, the role of its gene product Nav1.8 as a modulator of cardiac ion currents is unknown. Objective: We determined the electrophysiological and pharmacological properties of Nav1.8 in heterologous cell systems and assessed the antiarrhythmic effect of Nav1.8 block on isolated mouse and rabbit ventricular cardiomyocytes. Methods and Results: We first demonstrated that Scn10a transcripts are identified in mouse heart and that the blocker A-803467 is highly specific for Nav1.8 current over that of Nav1.5, the canonical cardiac sodium channel encoded by SCN5A . We then showed that low concentrations of A-803467 selectively block “late” sodium current and shorten action potentials in mouse and rabbit cardiomyocytes. Exaggerated late sodium current is known to mediate arrhythmogenic early afterdepolarizations in heart, and these were similarly suppressed by low concentrations of A-803467. Conclusions: Scn10a expression contributes to late sodium current in heart and represents a new target for antiarrhythmic intervention.
Local infusion of infliximab for the treatment of acute joint inflammation
Authors: M Bokarewa
Journal: Annals of the Rheumatic Diseases (2003)

A 13 year old girl presented with auricular chondritis and recurrent episodes of unexplained chest pain, arthritis, bronchitis, conjunctivitis, prolonged steroid resistant alopecia areata, and a history of recurrent tonsillitis.Both the mosaic of autoimmunity and relapsing polychondritis were considered in the differential diagnosis.The patient was successfully treated with co-trimoxazole.The significance of co-trimoxazole, which is an antibiotic and an immunomodulatory drug, in the treatment of autoimmune disease is discussed.www.annrheumdis.
Atypical manifestations of gastrooesophageal reflux
Authors: P. Duffey
Journal: Journal of the Royal Society of Medicine (2004)

I agree with Dr Walden 1 and Dr Doney 2 that guidelines can be dangerous as they can have a spurious authority.In time all guidelines will be shown to be partly or wholly wrong.They may even be politically engineered.The 1999 publication Drug Misuse and Dependence-Guidelines on Clinical Management 3 is an example.It contains serious errors of fact and ignores good evidence that conflicts with its 'consensus' views.These guidelines are published by the Department of Health as '. . .clinical interventions for drug misuse and dependence are subject to a number of regulations for the prescribing of controlled drugs . ..' (p.xiv).If that were so then guidelines on palliative care would also be written by the Department of Health.It is clear that these guidelines are subject to political scrutiny and if unacceptable to the Department of Health they would not be published.The guidelines then state (p.xv) '. . .any doctor not fulfilling the standards and quality of care in the appropriate treatment of drug users that are set out in these Clinical Guidelines, will have this taken into account if, for any reason consideration of their performance in this clinical area is undertaken . ..'.The guidelines then say '. . . in that these Guidelines do represent a consensus view of good clinical practice, it is expected they will be a significant reference point in assisting the General Medical Council [GMC] in its power to examine reports of poor performance by medical practitioners . ..'.These guidelines are concealed government regulation that in this context is an act of deception.Also, the GMC must have been involved in discussions about these guidelines before their publication, thus gravely impairing the GMC's impartiality.Beware of guidelines!
DOES ANGIOTENSIN PLUS ALDOSTERONE INHIBITION IMPROVE CORONARY ENDOTHELIAL FUNCTION? AN ANCILLARY STUDY FROM THE NHLBI-SPONSORED WOMEN'S ISCHEMIA SYNDROME EVALUATION (WISE)
Authors: Anthony A. Bavry, Eileen M. Handberg, Xuerong Wen, R. David Anderson, Karen M. Smith, Amir Lerman, Arshed Quyyumi, Chrisandra Shufelt, Rhonda M. Cooper-DeHoff, George Sopko, Carl J. Pepine
Journal: Journal of the American College of Cardiology (2011)
Minimal Brain Dysfunction-Reply
Authors: Jerry Newton
Journal: JAMA (1976)

In my opinion, it is a disservice to both medicine and education to argue over whether there is or is not such a thing as minimal brain dysfunction. One fact is not arguable—there are large numbers of children with normal intelligence who do poorly in the traditional classroom. I understand and am sympathetic with Dr Baumann's (and Dr Burton Schmitt's) opinions, but I seriously doubt if this nomenclature has hindered any progress.  The present state of the art is a result of a natural evolutionary process that is seen in many fields of scientific endeavor. It can be described in one word—confusing. At this stage, it is only natural that we refer to it as a syndrome. Many investigators 1 have already begun to proceed with the difficult task of studying these children, and eventually the term MBD syndrome will gradually disappear along with the vapours and neurasthenia.
&lt;emph type="ital"&gt;BRCA&lt;/emph&gt; Genes and Breast Cancer
Authors: Ryszard M. Pluta, Robert M. Golub
Journal: JAMA (2011)

BRCA Genes and Breast CancerA mong women, the lifetime risk of developing breast cancer is 1 in 8, and this disease is the second leading cause of cancer deaths (after lung cancer).The presence of a mutation (inherited abnormality) in breast cancer susceptibility gene 1 or 2 (BRCA1/2) significantly increases the risk of breast and ovarian cancers.
The Antiquity of the Erosive Arthropathies
Authors: J Dequeker
Journal: Annals of the Rheumatic Diseases (1990)

<h3>ABSTRACT</h3> Chromatin elements and regulators play important roles during progression of prostate cancer, however, their involvement in response to therapy is less well understood. Using comprehensive chromatin profiling of patient-derived tumors, we find that enhancer elements marked by H3K4me1 are highly enriched in aggressive therapy-resistant prostate cancers on important resistance-driving genes, such as those involved in FOXA1, NOTCH and TGF-β signaling. Importantly, by targeting H3K4me1-elements through inhibition of the MLL complex, a H3K4 methyltransferase, we reduced the proliferative capacity and H3K4me1-associated loci in enzalutamide-resistant prostate cancer lines. We identify AR, FOXA1, HOXB13 and SOX4 as a subset of core TFs that are critical for establishing transcriptional networks via active enhancer reprogramming during acquisition of resistance to therapy. Knock-down of SOX4 reduced cell proliferation and disrupted the H3K4me1 enhancer landscape, further suggesting a role for this TF in therapy-resistance. Overall, our data implicate H3K4me1-marked enhancers as a key epigenetic feature of therapy-resistance, implicate SOX4 in enhancer reprogramming and suggest use of MLL/MENIN inhibitors as a potential therapeutic strategy in high-grade and locally advanced prostate cancers that do not respond to traditional therapies.
The hedgehog pathway regulates remodelling responses to biliary obstruction in rats
Authors: A Omenetti, Y Popov, Y Jung, S S Choi, R P Witek, L Yang, K D Brown, D Schuppan, A M Diehl
Journal: Gut (2008)

<h3>Background:</h3> Chronic biliary obstruction provokes fibrosis and accumulation of immature ductular cells. This fibroductular reaction resolves following biliary decompression, suggesting that it may also be involved in the repair of biliary damage. The hedgehog (Hh) pathway becomes activated in liver after bile duct ligation (BDL), and might modulate hepatic remodelling because Hh ligands are potent morphogens. <h3>Objective:</h3> To study the induction of the Hh pathway during progression and resolution of biliary fibrosis, and to clarify whether Hh signalling regulates accumulation of bile duct progenitor cells. <h3>Design and main outcome measures:</h3> Livers from rats with BDL were examined by quantitative real-time polymerase chain reaction analysis and immunohistochemistry to identify factors that might stimulate Hh signalling. BDL rats were subjected to Roux-en-Y hepaticojejunostomy (R-Y) to relieve biliary obstruction in order to determine whether these factors and Hh signalling declined as ductular populations and concomitant fibrosis regressed. Cultures of immature ductular cells were treated with putative Hh inducers and Hh ligands to confirm their functional relevance. <h3>Results:</h3> BDL increased expression of platelet-derived growth factor-BB (PDGF-BB) and sonic hedgehog (Shh), downregulated hedgehog-interacting protein (Hip), activated Hh signalling, and expanded populations of Hh-responsive ductular cells that expressed pancyotkeratin, a liver progenitor cell marker. After R-Y, Hip remained suppressed, expression of PDGF-BB and Shh gradually declined, and populations of hedgehog-responsive ductular cells regressed. In cultured ductular cells, PDGF-BB treatment induced Shh expression, and incubation with Shh inhibited apoptotic activity. <h3>Conclusions:</h3> These results identify a mechanism for activation of the Hh pathway during cholestasis and suggest that Hh signalling regulates ductular cell accumulation after biliary injury.
Are Mortality Differences Detected by Administrative Data Reliable and Actionable?
Authors: John P. A. Ioannidis
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genome-wide linkage analysis of serum creatinine in three isolated European populations
Authors: Cristian Pattaro, Yurii S. Aulchenko, Aaron Isaacs, Veronique Vitart, Caroline Hayward, Christopher S. Franklin, Ozren Polasek, Ivana Kolcic, Zrinka Biloglav, Susan Campbell, Nick Hastie, Gordan Lauc, Thomas Meitinger, Ben A. Oostra, Ulf Gyllensten, James F. Wilson, Irene Pichler, Andrew A. Hicks, Harry Campbell, Alan F. Wright, Igor Rudan, Cornelia M. van Duijn, Peter Riegler, Fabio Marroni, Peter P. Pramstaller
Journal: Kidney International (2009)
Effect of Antihypertensive Drugs on Insulin, Glucose, and Lipid Metabolism
Authors: Hans O L Lithell
Journal: Diabetes Care (1991)

The close relationship between diabetes and hypertension has been recognized for decades. New information indicates that resistance to insulin action on glucose uptake in peripheral tissues is a common underlying mechanism in hypertension and diabetes. In prospective trials, the effects of antihypertensive agents on insulin sensitivity and lipoprotein metabolism have been evaluated. Both beta-blockers and thiazide diuretics worsen insulin resistance and deteriorate lipoprotein metabolism. Angiotensin-converting enzyme (ACE) inhibitors, Ca2(+)-channel blockers, and alpha-blockers are neutral or improve these factors. These data may explain the unexpectedly high incidence of the development of diabetes among treated hypertensives and the poor effect on risk for coronary heart disease in intervention trials.
Not So Small Vessel Vasculitis
Authors: Anthony M. Burrows, Patrick R. Maloney, Jamie J. Van Gompel
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Reduction of lupus nephritis in MRL/lpr mice by a bacterial superantigen treatment.
Authors: C Kim, K A Siminovitch, A Ochi
Journal: The Journal of Experimental Medicine (1991)

The effects of biweekly intravenous injections of Staphylococcus Enterotoxin B (SEB) into autoimmune MRL-lpr/lpr (MRL/lpr) mice were investigated. Rather than causing the expansion of V beta 8+ T cells, SEB administration resulted in the reduction V beta 8+, CD4-CD8- "double-negative" (DN) T cells. This was shown by FACS analysis as this putative pathogenic population was diminished in both spleen and lymph node. The symptoms of systemic lupus erythematosus (SLE) in MRL/lpr, which include high titers of anti-DNA antibodies and circulating immune complexes and proteinuria, were reduced in SEB-treated mice in a dose-dependent manner. The clinical parameters of SLE in MRL/lpr, which include lymph node hyperplasia and necrotic vasculitis, were suppressed in 50-micrograms SEB-treated mice. T cells bearing V beta 6 T cell receptor, which does not interact with SEB, were not reduced with SEB administration. Thus, disease suppression was associated with a specific reduction in the number of V beta 8+, DN T cells. These results implicate a possible therapeutic role of superantigen-based immunotherapy in V beta-restricted, T cell-dominated clinical syndromes.
A Qualitative Platelet Defect in Severe Vitamin B<sub>12</sub>Deficiency
Authors: PETER H. LEVIN
Journal: Annals of Internal Medicine (1973)

Three patients with vitamin B12 deficiency had profound qualitative platelet abnormalities: lack of secondary aggregation (release reaction) with ADP stimulation, total lack of aggregation in response to standard amounts of epinephrine or collagen, and, in two patients, bleeding times of more than 20 minutes. Vitamin B12 therapy corrected all these defects. Serial studies, after vitamin B12 administration, showed increased platelet aggregation response in two of the patients, when compared with 60 healthy controls. All three developed increased platelet factor 3 availability. One patient developed evidence of arterial and venous thrombi at this time, with no thrombocytosis. A retrospective chart review suggests that thrombotic episodes during recovery from vitamin B12 deficiency are not rare. The platelet apparently is one of the cells of the body that are susceptible to metabolic abnormality in severe vitamin B12 deficiency. Platelet function may be extremely important in the pathogenesis of both hemorrhage and thrombosis.
European survey on principles of prudent antibiotic prescribing teaching in undergraduate students
Authors: C. Pulcini, F. Wencker, N. Frimodt-Møller, W.V. Kern, D. Nathwani, J. Rodríguez-Baño, G.S. Simonsen, V. Vlahović-Palčevski, I.C. Gyssens, I.C. Gyssens, F. Jacobs, W. Peetermans, I. Francetić, V. Vlahović-Palčevski, N. Frimodt-Mǿller, N. Høiby, M. Kilian, F. Ader, C. Cazorla, M. Etienne, C. Pulcini, G. Fätkenheuer, W.V. Kern, M.W. Pletz, B. Salzberger, B. Cacopardo, M. Mikulska, C. Mussini, G. Orlando, S. Stefani, I.C. Gyssens, S.H. Lowe, J.L. Nouwen, J.E. Afset, K. Bergh, F. Müller, G.S. Simonsen, B. Carevic, O. Horvat, S. Jankovic, B. Beović, J.R. Gorisek, R. Canton, M.C. Fariñas, F. Gudiol, J.R. Paño Pardo, J. Rodríguez Baño, S. Harbarth, G. Zanetti, G. Barlow, N. Brown, B. Healy, D. Nathwani
Journal: Clinical Microbiology and Infection (2014)
Basophils Autoinduced Degranulation (BAD) Test. A New Variant Of Basophils Activation Test (BAT) As Reliable In Vitro Tool For The Diagnosis Of Chronic Autoimmune Urticaria (CAU)
Authors: M. Caruso, G. Tringali, C. Russo, R. Polosa
Journal: Journal of Allergy and Clinical Immunology (2012)
Associations between CMS's Clinical Performance Measures project benchmarks, profit structure, and mortality in dialysis units
Authors: L.A. Szczech, P.S. Klassen, B. Chua, S.S. Hedayati, M. Flanigan, W.M. McClellan, D.N. Reddan, R.A. Rettig, D.L. Frankenfield, W.F. Owen
Journal: Kidney International (2006)