tbuckley/cabot-search huggingface dataset:
Mesenchymal stem cells derived from adipose tissue are not affected by renal disease
Authors: Marieke Roemeling-van Rhijn, Marlies E.J. Reinders, Annelies de Klein, Hannie Douben, Sander S. Korevaar, Fane K.F. Mensah, Frank J.M.F. Dor, Jan N.M. IJzermans, Michiel G.H. Betjes, Carla C. Baan, Willem Weimar, Martin J. Hoogduijn
Journal: Kidney International (2012)
Surgical Care of Complicated Gastric and Duodenal Ulcer in Small Hospitals
Authors: Ralph Adams, Sidney B. Luria
Journal: New England Journal of Medicine (1953)

THIS report is concerned with the surgical care of gastric and duodenal ulcers in two small hospitals in New Hampshire. It covers a period of two and a half years, ending June 30, 1953, during which gastric resection for gastric, duodenal or gastrojejunal ulcer was performed in 103 cases.The types of ulcer and primary indications for resection are presented in Table 1. Intractability includes failure of either a gastric or duodenal ulcer to heal on medical therapy, persistent pain or bleeding on a good medical program and repeated perforation.The circumstances of gastric resection are outlined in Table 2. The word . . .
Newly diagnosed rheumatoid arthritis
Authors: M H Weisman
Journal: Annals of the Rheumatic Diseases (2002)

We can now affect the natural history of RA

Although the concept would sound heretical in some quarters, rheumatoid arthritis (RA) may now be a treatable disease. The aphorism of 25 years ago that “we don't treat RA, we manage the patient with the disease” may no longer be operative. Emery and colleagues in this issue of the Annals have made a recommendation (called a “clinical guide”) for how and when primary care physicians can identify patients with suspected RA and refer them to a rheumatology specialist.1 They state, unequivocally, that the initiation of disease modifying antirheumatic drugs (DMARDs) very early in the course of RA will improve patient outcome and increase long term quality of life. Their paper makes a compelling argument in favour of this recommendation; however, several issues dealt with in the article do raise questions that are in need of additional data and clarification.

### Evaluation of published reports

The approach of Emery et al was to perform a literature database search and then to use an accepted classification scheme2 to evaluate published clinical evidence based on the potential for bias to influence the results, giving randomised clinical trials the highest marks and expert opinion the lowest. Well performed observational inception cohort studies appear to have received an intermediate value. The supporting evidence and the proposed clinical recommendation were later circulated among these six wise men for critical evaluation and consensus building. The net result of their efforts is not only a referral recommendation but also a practical clinical tool employed by primary care physicians to identify patients suspected of having RA during the early stages of the disease. The technique for evaluation of early RA, which has recently been validated,3 is based upon a composite compression test of the hand or “squeeze” test, illustrated in the article, …
The short-term benefit and long-term failure of ultraviolet light in the treatment of venous leg ulcers
Authors: H.J. DODD, I. SARKANY, P.M. GAYLARDE
Journal: British Journal of Dermatology (1989)

Journal Article The short‐term benefit and long‐term failure of ultraviolet light in the treatment of venous leg ulcers Get access H.J. DODD, H.J. DODD Department of Dermatology, Royal Free Hospital, Hampstead, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar I. SARKANY, I. SARKANY Department of Dermatology, Royal Free Hospital, Hampstead, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.M. GAYLARDE P.M. GAYLARDE Department of Dermatology, Royal Free Hospital, Hampstead, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 120, Issue 6, 1 June 1989, Pages 809–818, https://doi.org/10.1111/j.1365-2133.1989.tb01379.x Published: 01 June 1989
RUNX3 Inhibits the Expression of Vascular Endothelial Growth Factor and Reduces the Angiogenesis, Growth, and Metastasis of Human Gastric Cancer
Authors: Zhihai Peng, Daoyan Wei, Liwei Wang, Huamei Tang, Jun Zhang, Xiangdong Le, Zhiliang Jia, Qiang Li, Keping Xie
Journal: Clinical Cancer Research (2006)

Abstract Purpose: Recent studies indicated that RUNX3 exhibits potent antitumor activity. However, the underlying molecular mechanisms of this activity remain unclear. In the present study, we used a gastric cancer model to determine the effect of RUNX3 expression on tumor angiogenesis. Experimental Design: The effects of increased RUNX3 expression on vascular endothelial growth factor (VEGF) expression in and angiogenic potential of human gastric cancer cells were determined in vitro and in animal models. RUNX3 and VEGF expression was determined in 120 human gastric cancer specimens and their relationship was analyzed. Results: RUNX3 gene transfer suppressed VEGF expression in human gastric cancer cells. Down-regulation of VEGF expression correlated with a significantly impaired angiogenic potential of human gastric cancer cells. Furthermore, RUNX3 restoration inhibited tumor growth and metastasis in animal models, which was consistent with inhibition of angiogenesis as determined by evaluating VEGF expression and tumor microvessel formation. In gastric cancer specimens, loss or decrease in RUNX3 expression inversely associated with increased VEGF expression and elevated microvessel formation. Conclusions: Our clinical and experimental data provide a novel molecular mechanism for the antitumor activity of RUNX3 and may help design effective therapy targeting RUNX3 pathway to control gastric cancer growth and metastasis.
C-reactive protein, pretreatment with statins, and multifocal activation of coronary artery disease in patients with primary unstable angina
Authors: Michael N. Zairis, Stavros Manousakis, Olga Papadakie, Denis Vitalis, Maria Thoma, Evangelos Tsanis, Thomas Matsikas, George Papadopoulos, Kostas Katsaros, Demetrios Beldekos, Christopher Olympios, Stefanos Foussas
Journal: Journal of the American College of Cardiology (2002)
Kidney oxygenation during water diuresis and endothelial function in patients with type 2 diabetes and subjects at risk to develop diabetes
Authors: Panayiotis A Economides, Antonella Caselli, Chun S Zuo, Caitlin Sparks, Lalita Khaodhiar, Nicholas Katsilambros, Edward S Horton, Aristidis Veves
Journal: Metabolism (2004)
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells
Authors: Lucy J. Walker, Yu-Hoi Kang, Matthew O. Smith, Hannah Tharmalingham, Narayan Ramamurthy, Vicki M. Fleming, Natasha Sahgal, Alistair Leslie, Ye Oo, Alessandra Geremia, Thomas J. Scriba, Willem A. Hanekom, Georg M. Lauer, Olivier Lantz, David H. Adams, Fiona Powrie, Eleanor Barnes, Paul Klenerman
Journal: Blood (2011)
Ethics of Health Care
Authors: H. Tristram Engelhardt
Journal: JAMA (1975)

Medical ethics has developed as a field concerned with determining the nature of the rights and duties, and the values and goods that should be at stake in health care. As a normative enterprise focusing on what<i>ought</i>to be the case, rather than as a descriptive enterprise focusing on what<i>is</i>the case, medical ethics has become increasingly the province of theologians and philosophers. In contrast, this book draws broadly on the experitise of physicians, medical educators, lawyers, sociologists, and an economist, in addition to theologians. The volume is composed of ten major papers and 11 commentaries, given as a part of the National Academy of Science's "Conference on Health Care and Changing Values," held in November 1973. The conference title indicates the content of the volume better than the title of the book: it is a wide-ranging account of the forces and values at work in shaping the
Sympathetic Nerve Activity in End-Stage Renal Disease
Authors: Martin Hausberg, Markus Kosch, Patrick Harmelink, Michael Barenbrock, Helge Hohage, Klaus Kisters, Karl Heinz Dietl, Karl Heinz Rahn
Journal: Circulation (2002)

Background— Uremia is proposed to increase sympathetic nerve activity (SNA) in hemodialysis patients. The aims of the present study were to determine whether reversal of uremia by successful kidney transplantation (RTX) eliminates the increased SNA and whether signals arising in the diseased kidneys contribute to the increased SNA in renal failure. Methods and Results— We compared muscle sympathetic nerve activity (MSNA) in 13 hemodialysis patients wait-listed for RTX and in renal transplantation patients with excellent graft function treated with cyclosporine (RTX-CSA, n=13), tacrolimus (RTX-FK, n=13), or without calcineurin inhibitors (RTX-Ø, n=6), as well as in healthy volunteers (CON, n=15). In addition to the above patients with present diseased native kidneys, we studied 16 RTX patients who had undergone bilateral nephrectomy (RTX-NE). Data are mean±SEM. MSNA was significantly elevated in hemodialysis patients (43±4 bursts/min), RTX-CSA (44±5 bursts/min), RTX-FK (34±3 bursts/min), and RTX-Ø (44±5 bursts/min) as compared with CON (21±3 bursts/min), despite excellent graft function after RTX. RTX-NE had significantly reduced MSNA (20±3 bursts/min) when compared with RTX patients. MSNA did not change significantly with RTX in 4 hemodialysis patients studied before and after RTX (44±6 versus 43±5 bursts/min, P =NS). In contrast, nephrectomy resulted in reduced MSNA in all 6 RTX patients studied before and after removal of the second native kidney. Conclusions— Despite correction of uremia, increased SNA is observed in renal transplant recipients with diseased native kidneys at a level not significantly different from chronic hemodialysis patients. The increased SNA seems to be mediated by signals arising in the native kidneys that are independent of circulating uremia related toxins.
Metoclopramide in Diabetic Gastroparesis
Authors: WILLIAM A. HARTONG
Journal: Annals of Internal Medicine (1977)

Comments1 June 1977Metoclopramide in Diabetic GastroparesisWILLIAM A. HARTONG, JOHN MOORE, J. P. BOOTHWILLIAM A. HARTONG, JOHN MOORE, J. P. BOOTHAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-6-826_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Drs. Longstreth, Malagelada, and Kelly (1) report some interesting physiologic and therapeutic effects of metoclopraminde in gastroparesis diabeticorum. As they have noted, there have been individual reports of beneficial effect of metoclopramide in diabetic gastroparesis (2, 3). We have also observed a beneficial effect on gastric motility in a young patient with severe gastroparesis.A 30-year-old woman was referred for evaluation of recurrent vomiting and poor control of her juvenile onset diabetes mellitus. Two years, before hospital admission she had had episodes of vomiting not controlled with conventional antiemetic therapy. These episodes got worse during a pregnancy...References1. LONGSTRETHMALAGELADAKELLY GJK: Metoclopramide Stimulation of gastric motility and emptying in diabetic gastroparesis. Ann Intern Med 86:195-196, 1976 LinkGoogle Scholar2. TETECOLLARD RN: Gastroparésis et gastroplégia diabétique. La Diabétique:233-241, 1972 Google Scholar3. BROWNLEEKROOPF MS: Metoclopramide for gastroparesis diabeticorum. N Engl J Med 291:1257-1258, 1974 CrossrefMedlineGoogle Scholar4. BERKOWITZMETZGERSTURDEVANT DWR: Oral metoclopramide in diabetic gastroparesis and in chronic gastric retention after gastric surgery (abstract). Gastroenterology 70:863, 1976 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM A. HARTONG; JOHN MOORE; J. P. BOOTHAffiliations: MC USA Department of Gastroenterology Dwight D. Eisenhower Army Medical Center Fort Gordon, GA 30905 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGastroparesis and Cancer-Related GastroparesisGastroparesis and Cancer-Related GastroparesisBibliographyMetoclopramide: Pharmacology and Clinical ApplicationRIYAD ALBIBI, M.D., RICHARD W. McCALLUM, M.D.Diabetic autonomic neuropathyMetoclopramide therapy in patients with delayed gastric emptying 1 June 1977Volume 86, Issue 6Page: 826-826KeywordsDiabetes mellitusGastroparesisPregnancyVomiting ePublished: 1 December 2008 Issue Published: 1 June 1977 PDF downloadLoading ...
SOME ASPECTS OF THE NEWER PHYSIOLOGY OF THE GASTROINTESTINAL CANAL.
Authors: LAFAYETTE B. MENDEL
Journal: JAMA (1904)

The relationship which exists between the functions of the digestive tract and that ensemble of biologic processes termed nutrition is both manifold and farreaching. It may perhaps be regarded as one of the shortcomings of the strictly "cellular" physiology of the century just closed that it failed to point out the conditions of interdependence and co-operation noticeable between different physiologic tissues. The modern organo-physiology is again beginning to emphasize a large number of such connections which have too frequently been overlooked, especially in a practical way. The physician should recognize in the study of alimentation something more than the mere consideration of the solvent action which the digestive secretions can exert. Thus Bidder and Schmidt wrote over fifty years ago in their classic work,<i>'Die Verdauungssäfte und der Stoffwechsel": "Wir finden einen zweiten und wesentlichen Theil der Bedeutung der Verdauungssäfte darin, dass sie Träger und Vermittler des innerhalb</i>
The Proteasome Inhibitor Bortezomib Sensitizes Melanoma Cells toward Adoptive CTL Attack
Authors: Jens Michael Seeger, Patrick Schmidt, Kerstin Brinkmann, Andreas A. Hombach, Oliver Coutelle, Paola Zigrino, Diana Wagner-Stippich, Cornelia Mauch, Hinrich Abken, Martin Krönke, Hamid Kashkar
Journal: Cancer Research (2010)

Adoptive transfer of tumor-specific cytolytic T lymphocytes (CTL) results in target cell lysis by activating the intrinsic apoptotic cell death program. Not surprisingly, deregulation of the apoptotic machinery is one of the central mechanisms by which tumor cells escape immune destruction despite specific CTL recognition. Here we show that treatment with the proteasome inhibitor bortezomib sensitizes previously resistant tumor cells for cytolytic T-cell attack. Human T cells were redirected toward melanoma cells by engineered expression of an immunoreceptor with binding specificity for high molecular weight-melanoma-associated antigen. Established melanoma cell lines as well as primary melanoma cells from tumor biopsies, which are notoriously resistant toward T-cell lysis, became sensitive upon bortezomib treatment. Detailed analysis of the underlying molecular mechanism revealed that bortezomib treatment induced mitochondrial accumulation of NOXA, which potentiated the release of mitochondrial second mitochondria-derived activator of caspase (SMAC) in response to CTL effector functions, including caspase-8 and granzyme B. Our data indicate that proteasome inhibition increases the sensitivity of tumor cells toward cytolytic T-cell attack by NOXA-mediated enhancement of mitochondrial SMAC release.
Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.
Authors: A M Genaro, S Hortelano, A Alvarez, C Martínez, L Boscá
Journal: Journal of Clinical Investigation (1995)

Incubation of ex vivo cultured mature B cells in the presence of nitric oxide or nitric oxide-donor substances delays programmed cell death as determined by the appearance of DNA laddering in agarose gel electrophoresis or by flow-cytometry analysis of DNA. Nitric oxide also rescues B cells from antigen-induced apoptosis but fails to provide a co-stimulatory signal that converts the signal elicited by the antigen into a proliferative response. The protective effects of nitric oxide against programmed cell death can be reproduced by treatment of the cells with permeant analogues of cyclic GMP. Regarding the mechanisms by which nitric oxide prevents apoptosis in B cells, we have observed that nitric oxide release prevents the drop in the expression of the protooncogene bcl-2, both at the mRNA and protein levels, suggesting the existence of an unknown pathway that links nitric oxide signaling with Bcl-2 expression.
LifeART Super Anatomy Collection
Authors: J. K. Smelz
Journal: JAMA (1993)

Life ART Super Anatomy is a medical anatomy clip art collection. (Other LifeART products include clip art collections on health care, emergency medicine, and dental art.) Anatomy drawings in this collection include sets of images showing systems—circulatory, digestive, endocrine, head and neck, joints, muscular, nervous, reproductive, respiratory, skeletal, and urinary—and body parts, including external images. There are 142 separate anatomic images, and the sets also have 21 icons.  In practice, these images actually produce a much higher number of figures (TechPool reports over 500), since they are designed to be ungrouped and grouped. For example, deleting the superficial back muscles in the posterior torso muscles figure will reveal the intermediate back muscles, and subsequent removal of these will show the deep muscles of the back. Most internal organs can be grouped to fit into their respective body cavities. Most cross-sectional views of organs will fit under the external organ view.
Pesticides--how research has succeeded and failed in informing policy: DDT and the link with breast cancer.
Authors: M S Wolff
Journal: Environmental Health Perspectives (1995)

Investigation of chemical exposures as possible etiologic factors for breast cancer has not been a research priority in the United States, which is surprising given the evidence from animal studies that environmental chemicals cause cancer and reproductive dysfunction. Study of environmental chemicals has also been indicated by the failure of traditional epidemiologic methods to account for significant proportions of breast cancer incidence with other risk factors. The fact that breast cancer risk is strongly associated with reproductive hormones is a further clue that environmental chemicals should be investigated. In addition to cancer, specific outcomes that need to be explored are reproductive dysfunction, immunotoxicity and neurotoxicity. Policy guiding our research should encourage toxicologic investigations of exposures to environmental chemicals that use state-of-the-art methods to determine exposure and human health effects. Using the approach suggested by John McLachlan, functional toxicology should be used to assess the activity of chemicals with regard to these outcomes. Just as dioxin toxicity can be expressed as toxic equivalents, estrogenic activity, for example, can be characterized in terms of estrogenic equivalents. In addition to the need to undertake this kind of research, needs for methods development and creative research funding mechanisms are discussed. Prevention of breast cancer may require intervention at an early age. Better understanding of breast cancer etiology, and especially its environmental components, may lead us toward that goal.
Chemoembolization: Transcatheter Management of Neoplasms
Authors: Vincent P. Chuang
Journal: JAMA (1981)

"Chemoembolization," the combination of intra-arterial infusion of a chemotherapeutic agent and arterial embolization of the vascular supply to a neoplasm as proposed by Kato et al elsewhere in this issue (p 1123), presents an interesting concept with considerable potential. In addition to the direct effect of ischemia on the neoplasm by temporary occlusion, the emboli decrease the transit time through the tumor vascular bed, theoretically increasing the contact time of the chemotherapeutic agent with the neoplastic cell, increasing local drug concentration, and probably increasing tissue permeability because of the anoxia. The cytotoxic effect is not only on the neoplasm, but on the vessel embolized and infused, producing vasculitis and occlusion. The systemic toxic effect may be reduced by metabolism of the drug on its first passage through the infused organ, thereby confining the higher concentration of the chemotherapeutic agent to the target organ. There is considerable clinical support for each
CHEST ROENTGENOGRAMS OF NONTUBERCULOUS CHILDREN SUSPECTED OF BEING TUBERCULOUS
Authors: ERNST WOLFF
Journal: JAMA (1930)

There exists a marked confusion in the interpretation of the shadows in the roentgenograms of children's chests. This is well illustrated by the recent paper of Hawes and Friedman<sup>1</sup>in which it was shown that no agreement existed in the six separate interpretations of a series of films given by a pediatrician, two tuberculosis specialists and three roentgenologists. The basic reason seems to be that there is no general agreement on the possible changes to be seen in a nontuberculous chest. This preliminary study was undertaken to determine the condition in the chests of nontuberculous children in order to establish a basis for a further study of the chests of tuberculous children. The cases studied were referred to the Children's Chest Clinic of the University of California Hospital because they represented symptoms suggesting tuberculosis or were regarded as possible contact cases. The control group consisted of normal children from
Psoriasis and Anti-convulsant Drugs
Authors: D. B. Brookes, T. W. Stewart
Journal: British Journal of Dermatology (1969)

Journal Article Psoriasis and Anti‐convulsant Drugs Get access D. B. Brookes, D. B. Brookes Department of Dermatology, Liverpool Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar T. W. Stewart T. W. Stewart Department of Dermatology, Liverpool Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 11, 1 November 1969, Page 868, https://doi.org/10.1111/j.1365-2133.1969.tb15963.x Published: 01 November 1969
Incidence of Dysplasia and Carcinoma of the Uterine Cervix in an Appalachian Population
Authors: G. H. Friedell, T. C. Tucker, E. McManmon, M. Moser, C. Hernandez, M. Nadel
Journal: JNCI Journal of the National Cancer Institute (1992)

Cervical cancer mortality rates in the Appalachian population of southeastern Kentucky have been shown to be unusually high. To better understand the high cervical cancer death rate in this area, we developed a population-based cervical disease registry.This study describes the incidence of cervical dysplasia, carcinoma in situ, and invasive cervical cancer in 1986 and 1987 among White women in a 36-county area of Appalachian Kentucky based on histologic diagnoses.We compared average annual age-adjusted incidence rates for carcinoma in situ and invasive cervical cancer in the study area with those for women in the Surveillance, Epidemiology, and End Results (SEER) Program.The incidence rate of invasive cervical cancer for women in the study area (14.9 per 100,000) was nearly twice that for White women in the SEER population (7.8 per 100,000), but it was similar to that for Black women in the SEER population (15.3 per 100,000). The incidence of carcinoma in situ for women in the study population (38.2 per 100,000) was 21% higher than that for White women (31.5 per 100,000) or for Black women (31.2 per 100,000) in the SEER population. The average annual age-adjusted incidence rate for all grades of dysplasia among women in the study population was 194.6 per 100,000. No comparable population-based incidence rates for dysplasia could be identified.Cervical cancer incidence rates are higher in Appalachian Kentucky than in the SEER population. Poverty appears to be a factor associated with these rates.Low-density populations such as those in rural Appalachia deserve greater attention in cancer control research. The population-based cervical dysplasia rates reported here may be useful for comparisons in future investigations.