tbuckley/cabot-search huggingface dataset:
PROFESSOR FLINT'S DOCTRINE OF THE SELF-LIMITATION OF PHTHISIS.Read at the Sixteenth Annual Meeting of the Mississippi Valley Medical Association, at Louisville, Oct. 8, 1890.
Authors: WILLIAM PORTER
Journal: JAMA (1890)

Sometime before his death Prof. Flint promulgated the doctrine of the self-limitation of phthisis, and presented it with all of his well known power and great ability to the profession. This very interesting proposition was at the time the subject of free debate in various medical societies, and at a former meeting of the Association I had the honor to partially discuss the position taken by this learned teacher and writer. The recent years have been full of the wonderful results of the study of pulmonary disease and bacteriologie research, and the possibility of a positive diagnosis has overshadowed the equally interesting question of prognosis. That Prof. Flint's arguments, however, have not been lost to the profession is evidenced by the repeated references to it in recent current medical literature, and many are ready to say with Prof. Stephen Burt, of New York, that "not a few cases of phthisis
The Dynamics of Pulsatile Blood Flow
Authors: LYSLE H. PETERSON
Journal: Circulation Research (1954)

The theory of dynamic fluid motion involving the forces manifested by mass, acceleration, viscous friction and vessel wall tension have been considered and studied when arterial blood flow and pressure are pulsatile. These studies and considerations have resulted in the conclusion that arterial blood pressure is dependent upon all of these parameters and that the relationship of pressure and flow is more complex and nonlinear than heretofore generally believed.
Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen
Authors: Valeria Cento, Formijn Van Hemert, Maria Neumann-Fraune, Carmen Mirabelli, Velia-Chiara Di Maio, Romina Salpini, Ada Bertoli, Valeria Micheli, Guido Gubertini, Sara Romano, Michela Visca, Giuseppe-Maria De Sanctis, Ben Berkhout, Nicoletta Marino, Francesco Mazzotta, Giuseppina Cappiello, Alberto Spanò, Cesare Sarrecchia, Francesca Ceccherini-Silberstein, Massimo Andreoni, Mario Angelico, Jens Verheyen, Carlo Federico Perno, Valentina Svicher
Journal: Journal of Infection (2013)
Abstract 1085: Nuclear localization and function of EphB4 in prostate cancer cells
Authors: Inga Mertens-Walker, Leslie Burke, Adrian C. Herington, Sally-Anne Stephenson
Journal: Cancer Research (2011)

Abstract EphB4 is a member of the largest group of receptor tyrosine kinases. EphB4 is significantly overexpressed in prostate cancer where it contributes to tumour progression as demonstrated through knock down of EphB4 in both in vitro and in vivo cell models. EphB4's interaction with its preferred ligand ephrin-B2 may lead, in some cases, to tumour suppression, suggesting therefore that ligand-independent effects are oncogenic. EphB4 is usually located to the plasma membrane, but using an in-house specific monoclonal antibody we have identified EphB4 in the nucleus of prostate cancer cell lines and patient tumour samples. Accordingly, we hypothesise that EphB4 can directly regulate gene expression in prostate cancer cells and that this may be at least one mechanism through which the ligand-independent effects on tumour progression may be manifested. Using chromatin immunoprecipitation with the specific EphB4 antibody we were able to precipitate numerous DNA sequences that are currently being validated. Using confocal microscopy we have discovered that EphB4 colocalises with SUMO-1 (small ubiquitin-like modifier-1). SUMOylation is a posttranslational modification by which one or multiple SUMO molecules are attached to certain lysine residues of a target protein and this can result in cytoplasmic-nuclear shuttling. In silico analysis of EphB4 revealed that it contains a highly conserved potential sumoylation site, K616. This is a highly novel and significant finding in the Eph receptor field and may provide a mechanism by which EphB4 localises to the nucleus. Further characterisation of EphB4 sumoylation and nuclear translocation is currently being undertaken. This study provides novel insight into Eph receptor biology and may identify a major new mechanism by which EphB4 can control gene expression and potentially influence cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1085. doi:10.1158/1538-7445.AM2011-1085
TCT-810 Long-term Safety of Everolimus-Eluting Bioresorbable Vascular Scaffold versus Cobalt-Chromium XIENCE V Stent in a Porcine Coronary Artery Model
Authors: Fumiyuki Otsuka, Erica Pacheco, Laura E. Perkins, Jennifer P. Lane, Qing Wang, Marika Kamberi, Kenichi Sakakura, Kazuyuki Yahagi, Elena Ladich, Richard Rapoza, Frank D. Kolodgie, Renu Virmani
Journal: Journal of the American College of Cardiology (2013)
Cognitive behavioural therapy for medically unexplained physical symptoms: a randomised controlled trial
Authors: A. E M Speckens, A. M van Hemert, P. Spinhoven, K. E Hawton, J. H Bolk, H. G M Rooijmans
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective</b>: To examine the additional effect of cognitive behavioural therapy for patients with medically unexplained physical symptoms in comparison with optimised medical care. <b>Design</b>: Randomised controlled trial with follow up assessments six and 12 months after the baseline evaluation. <b>Setting</b>: General medical outpatient clinic in a university hospital. <b>Subjects</b>: An intervention group of 39 patients and a control group of 40 patients. <b>Interventions</b>: The intervention group received between six and 16 sessions of cognitive behavioural therapy. Therapeutic techniques used included identification and modification of dysfunctional automatic thoughts and behavioural experiments aimed at breaking the vicious cycles of the symptoms and their consequences. The control group received optimised medical care. <b>Main outcome measures</b>: The degree of change, frequency and intensity of the presenting symptoms, psychological distress, functional impairment, hypochondriacal beliefs and attitudes, and (at 12 months of follow up) number of visits to the general practitioner. <b>Results</b>: At six months of follow up the intervention group reported a higher recovery rate (odds ratio 0.40; 95% confidence interval 0.16 to 1.00), a lower mean intensity of the physical symptoms (difference −1.2; −2.0 to −0.3), and less impairment of sleep (odds ratio 0.38; 0.15 to 0.94) than the controls. After adjustment for coincidental baseline differences the intervention and control groups also differed with regard to frequency of the symptoms (0.32; 0.13 to 0.77), limitations in social (0.35; 0.14 to 0.85) and leisure (0.36; 0.14 to 0.93) activities, and illness behaviour (difference −2.5; −4.6 to −0.5). At 12 months of follow up the differences between the groups were largely maintained. <b>Conclusion</b>: Cognitive behavioural therapy seems to be a feasible and effective treatment in general medical patients with unexplained physical symptoms.
Antazoline-induced allergic pneumonitis.
Authors: A Pahissa, J Guardia, J M Bofill, R Bacardi
Journal: BMJ (1979)

Antazoline-induced allergic pneumonitisAsthma and acute or chronic interstitial pneumonitis may be induced by several drugsl 2 but antazoline has not been incriminated.We therefore report a case of antazoline-induced acute interstitial pneumonitis and rash that was confirmed by a challenge test. Case reportA 35-year-old woman who smoked 20 cigarettes daily developed erythema at the injection site of an immunoglobulin preparation given for chronic rhinitis.The erythema was treated with antazoline hydrochloride (Antistin- Privine), 50 mg six-hourly.Seven hours after the second dose she complained of fever, rash, and dyspnoea, which subsided spontaneously.Three weeks later she was given 400 mg antazoline hydrochloride daily for two days.Because of dyspnoea, cough, fever, and an exanthematous rash, mainly on the anterior surface of the arms and legs, she was admitted to this hospital.No immunoglobulin preparations were given.Her temperature was 37 5'C.No rales were heard.Chest radiography showed alveolointerstitial shadows in the lower lung fields.White cell count (WCC) was 31 x 109/1 (31 000/mm3), with 87 % segmented neutrophils, 9 % band neutrophils, 2 % monocytes, 2 % lymphocytes, and no eosinophils.Rheumatoid factor was not detected but antinuclear factor antibody titre was 1/10 by indirect immunofluorescence.Concentrations of IgG, IgA, IgM, IgE, C3, and C4 were normal.Lung function values were: carbon monoxide transfer factor
The Training of the Internist
Authors: JEREMIAH A. BARONDESS
Journal: Annals of Internal Medicine (1979)

Efforts to provide an increased focus on the primary care activities of internists have been characterized by some as requiring a substantial increase in experience with ambulatory patients and significant training time invested in office gynecology, office orthopedics, otorhinolaryngology, and dermatology. These changes have been recommended as more reflective of the "real world" of the internist's practice than intensive experience with seriously ill inpatients. It is argued that such skills in training threaten to reduce clinical scope and deep competence and will thereby reduce rather than enhance effectiveness in the care of ambulatory patients. Deep clinical competence should be the hallmark of the internist, and training programs in internal medicine should be designed to produce this type of physician. In addition, consultant-level general internists should be trained for consultative, teaching, and investigative responsibilities and would be powerful role models for trainees.
A Case of Disseminated Insular Sclerosis
Authors: E. T. Wilson
Journal: BMJ (1876)

3. In a case I saw with Dr. Messer of Helensburgh, a feeble gentle- man, who had lived much abroad and was suffering from malignant disease of the bowel, had, a year before his fatal attack, suffered from complete obstruction for many days; and finally passed, with horrible pain, two very hard black and large masses (he had been taking iron at the time), after which his bowels acted freely and largely.I have only once known obstruction arise apparently from gall-s/ones; and the case is related, because it differs in an essential point from those recorded of occlusion from such a cause.Usually, it is one large gall-stone which has ulcerated its way out of the gall-bladder into the intestine; but here it seemed to be due to the rolling up of many com- mon gall-stones into a ball.4. A farmer's wife, aged 63, came to Glasgow from Perthshire to visit a son.She had suffered for years from " attacks of gall-stones", and had only recently recovered from a prolonged and severe seizure- to aid her recovery from which had been one object of her coming south.During the first week she was in town, she had one scanty motion; but for eight days before I was asked to see her, she had had no movement of her bowels.When I visited her, she had some pain down the right side of her abdomen and across the umbilicus.Pres- sure augmented this pain.There was somefulness of the belly.She was drowsy, and had some hiccup.She had rejected her food for the first time the night before I saw her, and, as she had continued to do this, her friends became alarmed and sought my aid.She supposed that she was about to suffer an attack of her old enemy, and had taken opium freely to relieve the pain.She had also taken large doses of various purgatives without medical advice.I could find nothing in the abdomen worthy of note, except the pain on pressure, the distension, and slight tympanites.A large enema passed easily and removed very little material from the bowel, though its use gave her a feeling of relief.Some flatus was occasionally passed.In the evening, the drowsiness having disappeared and the pain and restlessness being considerable, a large poultice was put over the belly, morphia administered subcutane- ously, and milk and ice in small quantities allowed.Beef-tea was twice thrown into the bowel during the night.Next day, there was little change.The pain was less, but the distension was greater and she was very sick and restless.Fifteen grains of calomel were given and retained, and at night (no motion having occurred) ten grains more were
103 VIROLOGICAL AND BIOCHEMICAL RESPONSE IN PATIENTS WITH HBEAG-NEGATIVE CHRONIC HEPATITIS B TREATED WITH PEGINTERFERON ALFA-2A (40KD) WITH OR WITHOUT LAMIVUDINE: RESULTS OF 4-YEAR FOLLOW-UP
Authors: P. Marcellin, T. Piratvisuth, M. Brunetto, F. Bonino, G.K.K. Lau, P. Farci, C. Yurdaydin, J. Wu, M. Popescu
Journal: Journal of Hepatology (2008)
Perindopril monotherapy and PROGRESS in Europe
Authors: Richard Wennberg, Camilla Zimmermann
Journal: BMJ (2005)

A tale of two Germanys Health problems in eastern Germany are clearly related to transitionEditor-The fall of the Berlin Wall in 1989 marked the beginning of the end of communism in eastern Europe and in eastern Germany.As McKee and Fister point out, 1 certain constellations of epidemiological and demographic variables characterise the resultant process of political and economic transition: low or even decreasing life expectancy (especially for men) and higher prevalences of alcoholism and obesity.This has happened in the postcommunist Länder (federal states) of eastern Germany.East Germany is different from other east European countries in that its healthcare sector was not deconstructed, with periods of severe dysfunction: it simply adopted the healthcare system of West Germany.Despite this, life expectancy at birth is still lower in eastern Germany than in western Germany, although the difference had diminished at the end of the 1990s. 2 Alcoholic disease is a feature of the typical transition process.The number of people discharged from hospital with alcoholic disease was higher in eastern Germany in 1994 and 1999 than in western Germany. 3 Obesity is another transition related problem and a risk factor for many diseases. 4 The proportion of the population with obesity (body mass index > 29.9) is higher in eastern Germany than in western Germany.This difference has remained for over 10 years after the fall of the Berlin Wall.In the medium term, the situation is set to even out.But it is remarkable that in spite of the same, well equipped (curative) health system, health care does not strongly modify mainly lifestyle linked health effects in a population that is exposed to transition after communism.For eastern Germany, the end of this transition process is in sight.
Corticosteroids for HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome
Authors: Timothy L Clenney, Anthony J Viera
Journal: BMJ (2004)

At our monthly meeting on maternal morbidity we discussed a 31 year old woman at 35 weeks' gestation. She was admitted to the labour and delivery ward because of elevated blood pressure (155/90 mm Hg). Laboratory tests showed increased levels of aspartate aminotransferase and alanine aminotransferase in addition to proteinuria. Her platelet count was 68 000. She received no corticosteroids antepartum or post partum for HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome, and both she and her infant did well.

In recent months we had cared for other women with HELLP syndrome who were given corticosteroids on the recommendation of our obstetrical consultants (none were present at the meeting). This experience raised the issue of whether such patients benefit from corticosteroids. The family physicians, obstetricians, and nurse midwives at the meeting were unable to reach consensus on this topic, and those with opinions were unaware of supporting evidence. As our question remained unanswered, we decided to assess current evidence. In doing so we framed the question: “Among patients with HELLP syndrome, does the administration of corticosteroids improve maternal morbidity in terms of both laboratory and clinical parameters?”

We searched Medline from 1966 to February 2004 using the key words “HELLP syndrome” (all subheadings) AND “corticosteroids” (which mapped to “adrenal cortex hormones”). Our search produced 36 citations. We reviewed the titles to determine which articles might answer …
When to Start Antiretroviral Therapy — Ready When You Are?
Authors: Paul E. Sax, Lindsey R. Baden
Journal: New England Journal of Medicine (2009)

The optimal time to start antiretroviral therapy in asymptomatic patients has been one of the central controversies in the care of patients with the human immunodeficiency virus (HIV) since the introduction of the first antiretroviral agent, zidovudine, more than two decades ago.1 Since then, periods of enthusiasm for aggressive early intervention2 have been followed by a more cautious approach.3 This slowly swinging pendulum has been pushed back and forth by the extraordinary benefits of antiretroviral therapy on one side4 and emerging data on its adverse effects on the other.5 The absence of a controlled, prospective study comparing early and deferred . . .
Does second-line therapy affect the radiological progression of rheumatoid arthritis?
Authors: T Pullar, J A Hunter, H A Capell
Journal: Annals of the Rheumatic Diseases (1984)

The effect of 9second-line9 drugs on radiological progression in rheumatoid arthritis is not clear, and previous studies have yielded contradictory results. Sixty-seven patients with rheumatoid arthritis have been followed up clinically and radiologically for approximately 2 years (26 patients were receiving intramuscular gold, 21 penicillamine, 10 levamisole, and there were 10 controls who had consistently refused second-line therapy). Patients on gold and penicillamine showed improvement in erythrocyte sedimentation rate and haemoglobin over 2 years which was not seen in levamisole and control patients, but hand radiograph scores in all 4 groups showed statistically significant deterioration. There was a trend towards slowing of the rate of erosion in the gold and penicillamine groups in comparison with controls, but healing of erosions was extremely unusual.
<i>The Organization of Life: A Revaluation of Evidence Relative to the Primary Factors in the Activity and Evolution of Living Organisms, Including a Factorial Analysis of Human Behavior and Experience.</i>By Seba Eldridge, Associate Professor in the University of Kansas. Introduction by H. S. Jennings, Professor of Zoology in Johns Hopkins University. (<i>New York: T. Y. Crowell Co., 1925.</i>)
Authors: Harry Stack Sullivan
Journal: American Journal of Psychiatry (1926)
Metabolic Syndrome in Brazilian Adolescents
Authors: Isabel Cristina Britto Guimarães, Alessandro Moura de Almeida, Armênio Costa Guimarães
Journal: Diabetes Care (2008)

Overweight/obesity plays a central role in metabolic syndrome, a major health problem from infancy to adulthood (1). To identify and apply preventive and therapeutic measures at its earliest stages, the prevalence of its components were studied among a sample of high normal–weight, overweight, and obese Brazilian adolescents (2).

A total of 314 adolescents aged mean ± SD 13.8 ± 1.97 years were selected from two private and two public schools, of whom 178 (56.7%) were girls and 163 (51.9%) nonwhites. The approval of the university ethics committee and written informed consent were obtained. The students were divided into three BMI-based groups: high normal (≥50th and <85th percentile) …
Illness and Indignity
Authors: Thomas S. Szasz
Journal: JAMA (1974)

ALL OF us in the health professions share certain fundamental aspirations and goals, among which the most important ones are keeping the healthy person healthy; restoring the sick person to health; and, most generally, safeguarding and prolonging life. That these ends are so overwhelmingly good and noble is what makes their pursuit so gratifying, and those in the health professions so richly honored and rewarded. Life would be simpler than it is if health and longevity were its only, or even its principal, purposes; or, to put it differently, if there were no goals or values that often conflict with their pursuit. One of the values that men and women—and children, too—cherish, and that often conflicts with their pursuit of health at any cost, is dignity. Dignity is, of course, that ineffable and yet obvious quality of human encounters and situations that enriches the participants' self-esteem. For example, in these
Structure, genesis, and criteria
Authors: Carol A. Miller, Ulrich Müller
Journal: Behavioral and Brain Sciences (2004)

We agree that social interaction is crucial for understanding the development of theory of mind, but suggest that further elaboration of certain issues is needed. Detailed description of the knowledge structure of a developing theory of mind is necessary, and the notion of criteria for the use of mental state terms requires consideration of the sentence structures in which such terms appear.
Abstract SY33-04: Tumor suppression by the DNA damage response
Authors: John Petrini
Journal: Cancer Research (2014)

Abstract The DNA damage response (DDR) is activated by oncogenic stress, but the mechanisms by which this occurs and the particular DDR functions that constitute barriers to tumorigenesis remain unclear. We established a mouse model of sporadic oncogene-driven breast tumorigenesis in a variety of mutant mouse strains with specific DDR deficiencies to reveal a novel role for the Mre11 complex (comprised of Mre11, Nbs1, and Rad50) in the response to oncogene activation. We demonstrate that the Mre11-mediated DDR suppresses tumorigenesis by inducing a G2 arrest and a program of chromatin alteration that, when compromised, results in oncogene-induced mammary hyperplasias that progress to invasive and metastatic breast cancers. In contrast, we provide genetic evidence that the intra-S checkpoint and the DNA damage-induced apoptosis functions of the DDR are dispensable for tumor suppression. These findings provide novel insight into the mechanism of DDR engagement by activated oncogenes, and reveal the particular DDR functions that must be overcome during tumorigenesis. We further demonstrate that impairment of these Mre11-dependent functions promotes metastatic dissemination, particularly upon secondary inactivation of the Ink4a-p19Arf (CDKN2a) locus. These findings provide insight into the mechanism of DDR engagement by activated oncogenes, and reveal a novel genetic interaction between the DDR and Ink4a-p19Arf pathways in suppression of oncogene-driven tumorigenesis and metastasis. Citation Format: John Petrini. Tumor suppression by the DNA damage response. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr SY33-04. doi:10.1158/1538-7445.AM2014-SY33-04
Heparin Lock-Induced Alterations in the Activated Partial Thromboplastin Time
Authors: Thomas J. O'Neill
Journal: JAMA (1974)

The placement of heparin locks can result in marked transient alterations in the activated partial thromboplastin time (APTT). This is noteworthy because of the current interest in mini-dose heparin regimens for preventing venous thrombosis and the recommendation that base line values for the APTT be obtained before starting therapy.