tbuckley/cabot-search huggingface dataset:
Silent ischemia after coronary angioplasty: Evaluation of restenosis and extent of ischemia in asymptomatic patients by tomographic thallium-201 exercise imaging and comparison with symptomatic patients
Authors: Harvey S. Hecht, Richard E. Shaw, Henry L. Chin, Colman Ryan, Simon H. Stertzer, Richard K. Myler
Journal: Journal of the American College of Cardiology (1991)
Relation priming, the lexical boost, and alignment in dialogue
Authors: Claudine N. Raffray, Martin J. Pickering, Holly P. Branigan
Journal: Behavioral and Brain Sciences (2008)

Abstract The authors' claim that analogical reasoning is the product of relational priming is compatible with language processing work that emphasizes the role of low-level automatic processes in the alignment of situation models in dialogue. However, their model ignores recent behavioral evidence demonstrating a “lexical boost” effect on relational priming. We discuss implications of these data.
Therapeutic Biliary Endoscopy
Authors: E. L. Fogel, L. McHenry, S. Sherman, J. L. Watkins, G. A. Lehman
Journal: Endoscopy (2005)

Some steps of progress have been seen in the area of biliary therapeutic endoscopy, in the understanding and management of primary sclerosing cholangitis, problems relating to liver transplantation, malignant biliary strictures, and complications after endoscopic retrograde cholangiopancreatography, as well as sphincter of Oddi dysfunction. These topics are reviewed here.
Reduction of no-reflow and infarct size by intraaortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study
Authors: Luciano Amado, Dara L. Kraitchman, Bernhard Gerber, Ernesto Castillo, Raymond C. Boston, Joseph Grayzel, Joao A.C. Lima
Journal: Journal of the American College of Cardiology (2003)
Abstract KN1: Finding mechanisms and biomarkers of drug resistance in cancer
Authors: René Bernards
Journal: Clinical Cancer Research (2010)

Abstract Unresponsiveness to therapy remains a significant problem in the treatment of cancer, also with the new classes of targeted therapeutics. In my laboratory, we use functional genetic approaches to identify biomarkers that can predict responsiveness to clinically relevant cancer therapeutics. We focus on targeted cancer drugs such as trastuzumab (Herceptin), PI3K inhibitors, MEK inhibitors, ALK inhibitors, mTOR inhibitors, Histone Deacetylase inhibitors and retinoic acid. These drug target specific molecules or pathways that are often activated in cancer. Nevertheless, it remains poorly explained why a significant number of tumors do not respond to the therapy. We aim to elucidate the molecular pathways that contribute to unresponsiveness to targeted cancer therapeutics using a functional genetic approach. This will yield biomarkers that may be useful to predict how individual patients will respond to these drugs. Furthermore, this work may allow the development of drugs that act in synergy with the established drug in the treatment of cancer. To identify biomarkers that control tumor cell responsiveness to cancer therapeutics, we use two complementary approaches. First, we use genome wide loss-of-function genetic screens (with shRNA interference libraries) in cancer cells that are sensitive to the drug-of-interest to search for genes whose down-regulation confers resistance to the drug-of-interest (resistance screens). In addition, we use single well siRNA screens with a low dose of the drug to screen for genes whose inhibition enhances the toxicity of the cancer drug (sensitizer screens). Once we have identified resistance and/or sensitizer genes, we ask if their expression is correlated with clinical response to the drug-of-interest using tumor samples of cancer patients treated with the drug in question, whose response to therapy is documented. Examples of genetic screens to identify mechanisms of resistance to different cancer drugs will be presented. Citation Information: Clin Cancer Res 2010;16(7 Suppl):KN1
Study of factors in atherogenesis.
Authors: J. T. Salonen, R. Salonen, K. Seppanen, M. Kantola, S. Suntioinen, H. Korpela
Journal: BMJ (1992)

or her partner together may enable the doctor to ask about the influence of the disease on their partnership and thus allow them to discuss emotionally loaded topics together.Local support groups can also be invaluable.Many patients and their partners find that the leaflets, meetings, and other facilities of the Multiple Sclerosis Society and Action for Research into Multiple Sclerosis provide support that neither health nor social service professionals can give.Offering to help patients with multiple sclerosis and their families in these ways is a vital aspect of management and will remain so until traditional therapeutic endeavours become effective.
Detection of Obstructive Arterial Disease
Authors: Jay D. Coffman
Journal: New England Journal of Medicine (1972)

Many physicians do not feel competent in the diagnosis of peripheral obstructive arterial disease. This fact reflects a tendency to omit examination of the peripheral vasculature in patients without complaints in that area or in routine physical examinations. Even in university-hospital settings, peripheral pulses are often not recorded in the detailed physical examinations. If the physician is not skilled in palpating normal pulses, he cannot expect to detect the abnormal. Patients with symptomatic aortoiliac atherosclerosis are frequently treated as orthopedic or neurologic problems, and those with lumbar-disk disease, neurogenic claudication, or arthritis are often referred to vascular specialists. What is . . .
Paracetamol-induced perforation of the esophagus in a patient with eosinophilic esophagitis
Authors: T. Spahn, M. Vieth, M. Mueller
Journal: Endoscopy (2010)

A 41-year-old female patient admitted herself to the emergency room with dysphagia 18 hours after ingesting a tablet of paracetamol. She had suffered from multiple episodes of dysphagia before. As shown in [Fig. 1], an upper gastrointestinal series radiograph taken after admission revealed obstruction of the proximal third of the esophagus. Emergency esophagoscopy revealed a dilated esophagus and the tablet at the end of the oral third of the esophagus ([Fig. 2 a]). After the tablet was gently mobilized, a membranous stricture and moderate hemorrhage became visible ([Fig. 2 b]). The patient subsequently developed chest pain, and computed tomography ([Fig. 3]) showed mediastinal air consistent with perforation. The patient improved under conservative therapy and was discharged 5 days later. On day 40 she presented again with dysphagia and underwent manometry of the esophagus, which showed no evidence of motility disorders. Esophagogastroduodenoscopy (EGD) revealed multiple, small, nodular lesions in the esophagus. Biopsies showed eosinophilic esophagitis ([Fig. 4]).
Abstract 2426: Anti-Glypican3 antibody for treatment of human liver cancer
Authors: Takahiro Ishiguro, Yasuko Kinoshita, Masamichi Sugimoto, Yoko Miyazaki, Atsuhiko Kato, Kiyotaka Nakano, Hirotake Takai, Hiroyuki Tsunoda, Izumi Sugo, Iwao Ohizumi, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko Kodama, Masayuki Tsuchiya, Hisafumi Yamada Okabe
Journal: Cancer Research (2010)

Abstract Glypican-3 (GPC3) is a member of the glypican family of heparan sulfate proteoglycans, which are linked to the cell surface through a glycosyl phosphatidyl inositol anchor. GPC3 has been reported to be highly expressed in the majority (70-100%) of HCC, and considered to play a role in the tumorigenesis of HCC. Although the molecular mechanism by which GPC3 functions in tumorigenesis has not been fully elucidated, the high prevalence in HCC has led to considerable interest in GPC3 as a diagnostic marker and therapeutic target. In this study, we obtained a monoclonal antibody (mAb) against the COOH-terminal part of GPC3, which induced antibody-dependent cellular cytotoxicity (ADCC). The mAb, designated mGC33, exhibited marked tumor growth inhibition of s.c. transplanted Hep G2 and HuH-7 xenografts that expressed GPC3 but did not inhibit growth of the SK-HEP-1 that was negative for GPC3. mGC33 was efficacious even in an orthotopic model; it markedly reduced the blood alpha-fetoprotein levels of mice intrahepatically transplanted with Hep G2 cells. To develop an antibody-based immunotherapy, we generated humanized GC33 (hGC33) by complementarily determining region (CDR) grafting. hGC33 was as efficacious as mGC33 against the Hep G2 xenograft, but hGC33 lacking carbohydrate moieties caused neither ADCC nor tumor growth inhibition. Depletion of CD56+ cells from human peripheral blood mononuclear cells markedly abrogated the ADCC caused by hGC33. The results show that the antitumor activity of hGC33 is mainly attributable to ADCC, and in human, natural killer cell-mediated ADCC is one possible mechanism of the antitumor effects by GC33. We also evaluated the antitumor activity of hGC33 combined with standard chemotherapy agent sorafenib. hGC33 and sorafenib combination was more potent in inhibiting tumor growth than sorafenib alone in the s.c. transplanted Hep G2 xenograft model. Administration of sorafenib alone did not change the GPC3 expression level in xenograft tumor. These suggest that this combination regimen may be clinically useful as an anti-liver cancer therapy. In careful examination of the safety of hGC33 in nonclinical studies, specific adverse findings on GPC3 expressed tissue or organs were not observed after repeated administration. Therefore hGC33 will provide a novel treatment option for liver cancer patients with GPC3-positive tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2426.
Somatic Reenactment in the Treatment of Posttraumatic Stress Disorder
Authors: Jacob D. Lindy, Bonnie L. Green, Mary Grace
Journal: Psychotherapy and Psychosomatics (1992)

Somatic reenactments, like other intrusive symptoms in posttraumatic stress disorder, such as flashbacks and nightmares, reproduce the mental content of traumatic events. Four cases are presented from survivors of military trauma and civilian catastrophes. The patients were part of larger research projects carried out by the University of Cincinnati Traumatic Stress Study Center. Understanding such symptoms as repetitions of the trauma itself proved useful therapeutically, especially in consolidating the working alliance.
Abstract 5622: Development of an experimental model to test cellular therapy in combination with cytokines as a novel treatment for ovarian cancer
Authors: Susan Blaydes Ingersoll, Sarfraz Ahmad, Sheylan Patel, Ahad Ahmed, John R. Edwards, Neil J. Finkler, Robert W. Holloway
Journal: Cancer Research (2010)

Abstract Because current therapies for ovarian cancer have little impact on long-term survival, there is a compelling need to develop innovative treatment strategies. Our aim was to develop in vitro and in vivo models to test cellular therapy in combination with cytokines or chemotherapies to elicit a graft versus tumor response to treat refractory ovarian cancer patients. SKOV-3 ovarian cancer cells, which were transfected with Red Fluorescent Protein (SKOV3-RFP) were passaged through nude mice to create more tumorigenic sub-lines. Two sub-lines were established, SKOV3-AF1 and SKOV3-AF2, which showed increased tumorigenicity compared to parental SKOV3-RFP cells. Both lines resulted in 100% tumor incidence in 6-8 weeks at a dose of 1 × 106 cells compared to 67% tumor incidence at 14 weeks at a dose of 5 × 106 SKOV3-RFP cells. SKOV3-AF1 and -AF2 cells were assayed to determine if peripheral blood mononuclear cells (PBMC) in combination with the cytokines IL-2 and IFNα-2b elicited a cytotoxic effect against the ovarian cancer cells. SKOV3-AF1 and-AF2 sub-lines were highly sensitive to cytotoxicity (up to 70%) mediated by PBMC (20:1 PBMC: SKOV3) in combination with IL-2 (25 ng/ml) and IFNα-2b (500 U/ml). The SKOV3-AF1 and -AF2 cells showed an average of 25% increased cytoxicity compared to parental SKOV3-RFP cells (p&amp;lt;0.05, n=3). Interestingly, SKOV3-AF1 and -AF2 were more resistant to IFNα-2b compared to SKOV3-RFP when cultured in the presence of IFNα-2b alone. In addition, gene expression of E-cadherin and Cysteine-rich 61 (CCN1), which have been shown to play a role in the patho-biology of ovarian cancer, was assessed in SKOV3-RFP, -AF1, and -AF2 cells as well as solid tumors harvested from mice. All SKOV3-derived lines and solid tumor expressed E-cadherin by RT-PCR. None of the SKOV3-derived lines expressed CCN1; however, one of the two SKOV3-AF1 solid tumors tested expressed CCN1. Both SKOV3-AF2 solid tumors evaluated showed weak expression of CCN1. The SKOV3-derived sub-lines that we developed will be a better model to test novel ovarian cancer treatment regimens because these lines were found to be more susceptible to PBMC-mediated cytotoxicity, exhibit increased resistance to IFNα-2b, are more tumorigenic in a xenograph model, and tumors harvested from these lines express genes that make these tumors more aggressive. Collectively, these results suggest that cytokine enhanced cellular therapy may be a viable treatment option for ovarian cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5622.
Incidence of breast cancer is rising in Australia, while death rate falls
Authors: Stephen Pincock
Journal: BMJ (2006)

The incidence of breast cancer among Australian women continues to rise. But more patients than ever before are surviving the disease, a report published this month says.

The number of new cases of breast cancer each year has more than doubled in the past 20 years, says the report, from the National Breast Cancer Centre and the Australian Institute of Health and Welfare. A total of 12 027 women were given a diagnosis of the cancer in 2002, up from 5318 in 1983.

Helen Zorbas, director of the centre, said the rise in incidence was only partly due to better diagnosis …
Impact of changes in the International Olympic Committee Medical Commission criteria for asthma
Authors: L-P Boulet
Journal: Thorax (2005)

Objective measurements of variable airflow obstruction in athletes using inhaled bronchodilators are needed if the non-indicated use of asthma drugs is to be prevented

A large number of Olympic athletes have asthma, and intense exercise has the potential to alter their sports performances in inducing troublesome respiratory symptoms.1,2 The prevalence of asthma in Olympic athletes has been reported to be between 9% and 55%.1–5 It is particularly high in winter sports athletes and in swimmers, and its prevalence has been reported to be increasing. Furthermore, high level training is thought to contribute to the development of airway hyperresponsiveness and symptomatic asthma.2,3

Although most current asthma medications, including the frequently used inhaled short acting β2 agonists, do not seem to have performance enhancing effects when used at doses required to prevent or treat exercise-induced bronchoconstriction, their use has been regulated.6–9 To ensure that they are used for an appropriate diagnosis, the International Olympic Committee-Medical Commission (IOC-MC) has established criteria for a positive diagnosis of asthma. It includes a significant bronchodilator response, or a positive bronchial provocation challenge, a fall in forced expiratory volume in 1 second of at least 10% from pre-challenge measures being required for exercise or eucapnic voluntary hyperpnoea.10

In this issue of Thorax , Dickinson et al looked at the influence of these recently established criteria on the prevalence of asthma in the British Olympic Team participating to the 2004 Olympic Games in comparison to the year 2000.4 In 2000 the diagnosis was established by analysing the pre-Olympic medical forms …
Natural progesterone and antihypertensive action
Authors: K Dalton
Journal: BMJ (1985)

paring different drugs for the treatment of serious arrhythmias.It does not follow, however, that the data obtained from such "single drug" studies are of no value.For example, in many studies using intracardiac techniques, tape monitoring, or exercise testing the patient acts as his own control and drug effect (or lack of it) can be accurately documented.There is now very good evidence that the acute effect of a drug on a ventricular tachycardia correlates well with long term suppression of the arrhythmia and prolonged survival.9Rigorously controlled comparisons of drugs in this patient group would be clinic- ally inappropriate and beset with ethical difficulties.We believe there is no place for an empirical approach to the treatment of tachycardias.Careful analysis of spontaneous recordings should allow correct diagnosis in most cases.Armed with this information and the clinical pattern of the arrhythmia, the physician should be able rationally to select a drug with known effects with a high chance of therapeutic success.
Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.
Authors: D Balomenos, R Rumold, A N Theofilopoulos
Journal: Journal of Clinical Investigation (1998)

Congenic MRL-lpr mice homozygous and heterozygous for the IFN-gamma gene disruption were created to assess the role of this pleotropic cytokine on the lymphoaccumulation and lupus-like disease of Fas-defective mice. Early death was prevented, and glomerulonephritis severely reduced in IFN-gamma-/- mice. Hypergammaglobulinemia was maintained with a switch from IgG2a to IgG1 predominance, but the dramatic decrease in levels of the dominant IgG2a anti-dsDNA autoantibodies was not associated with a compensatory increase in TH2-associated IgG subclasses. Remarkably, early death and glomerulonephritis were also prevented in IFN-gamma+/- mice, although autoantibody levels and glomerular immune deposits were equivalent to IFN-gamma+/+ lpr mice, indicating the importance of additional locally-exerted disease-promoting effects of IFN-gamma. IFN-gamma-/- mice exhibited reduced lymphadenopathy concomitant to a decrease in DN B220(+) T cells. In vivo BrdU labeling showed reduced proliferation of DN B220(+) cells in IFN-gamma-/- vs. IFN-gamma+/+ lpr mice, while enhanced proliferation of all other T cell subsets was unaffected. Macrophages of IFN-gamma-/-lpr mice expressed markedly decreased levels of MHC class I and II molecules compared with controls. Moreover, the heightened expression of MHC class II molecules on proximal tubules of IFN-gamma+/+ lpr mice was significantly reduced in both IFN-gamma-/- and IFN-gamma+/- mice. The data indicate that IFN-gamma hyperproduction is required for lupus development, presumably by increasing MHC expression and autoantigen presentation to otherwise quiescent nontolerant anti-self T cells, and also by promoting local immune and inflammatory processes.
Joint lavage and pseudogout
Authors: P Pasquetti
Journal: Annals of the Rheumatic Diseases (2004)

Joint lavage, although its efficacy is still under debate,1–6 seems to be effective, mostly, in the treatment of gonarthritis associated or not with chondrocalcinosis (CC).2,3,7 Paradoxically, acute pseudogout is a complication of this technique.8 Our study aimed at evaluating the incidence of pseudogout in 73 patients with gonarthritis, associated or not with CC, who underwent arthroscopic lavage (AL).

In this retrospective study we assessed the incidence of pseudogout attacks that occurred 24 hours after surgery in 73 consecutive patients with gonarthritis (52 women (71%), 21 men (29%)), who underwent AL of the knee at our hospital. All the patients had medium-severe symptomatic osteoarthritis, according to Kellgren and Lawrence’s classification (II-III-IV degrees),9 and were unresponsive to drugs (that is …
Pesticide Exposure Alters Follicle-Stimulating Hormone Levels in Mexican Agricultural Workers
Authors: Rogelio Recio, Guadalupe Ocampo-Gómez, Javier Morán-Martínez, Victor Borja-Aburto, Malaquías López-Cervantes, Marisela Uribe, Luisa Torres-Sánchez, Mariano E. Cebrián
Journal: Environmental Health Perspectives (2005)

Organophosphorous pesticides (OPs) are suspected of altering reproductive function by reducing brain acetylcholinesterase activity and monoamine levels, thus impairing hypothalamic and/or pituitary endocrine functions and gonadal processes. Our objective was to evaluate in a longitudinal study the association between OP exposure and serum levels of pituitary and sex hormones. Urinary OP metabolite levels were measured by gas-liquid chromatography, and serum pituitary and sex hormone levels by enzymatic immunoassay and radioimmunoassay in 64 men. A total of 147 urine and blood samples were analyzed for each parameter. More than 80% of the participants had at least one OP metabolite in their urine samples. The most frequent metabolite found was diethylthiophosphate (DETP; 55%), followed by diethylphosphate (DEP; 46%), dimethylthiophosphate (DMTP; 32%), and dimethyldithiophosphate (DMDTP; 31%). However, the metabolites detected at higher concentrations were DMTP, DEP, DMDTP, and dimethylphosphate. There was a high proportion of individuals with follicle-stimulating hormone (FSH) concentrations outside the range of normality (48%). The average FSH serum levels were higher during the heavy pesticide spraying season. However, a multivariate analysis of data collected in all periods showed that serum FSH levels were negatively associated with urinary concentrations of both DMTP and DMDTP, whereas luteinizing hormone (LH) was negatively associated with DMTP. We observed no significant associations between estradiol or testosterone serum levels with OP metabolites. The hormonal disruption in agricultural workers presented here, together with results from experimental animal studies, suggests that OP exposure disrupts the hypothalamic-pituitary endocrine function and also indicates that FSH and LH are the hormones most affected.
Diagnosis of broad complex tachycardias with ambulatory monitoring of atrial electrography.
Authors: D P Lipkin, E J Perrins, L M Shapiro, L Ludgate, K M Fox
Journal: BMJ (1984)

Simultaneous 24 hour ambulatory monitoring of the surface electrocardiogram and the intra-atrial electrocardiogram was evaluated in eight patients with broad complex tachycardia. The technique using a J shaped atrial pacing wire permitted a distinction between ventricular tachycardia and supraventricular tachycardia in all eight patients. Formal electrophysiological testing would still be required, however, in patients in whom diagnostic doubt remained.
Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model
Authors: Ju Hee Ryu, Jung-Youn Shin, Sun Ah Kim, Sun-Woong Kang, Hyunjoon Kim, Seokyung Kang, Kuiwon Choi, Ick Chan Kwon, Byung-Soo Kim, Kwangmeyung Kim
Journal: Biomaterials (2013)