tbuckley/cabot-search huggingface dataset:
Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.
Authors: W Chen, S Khilko, J Fecondo, D H Margulies, J McCluskey
Journal: The Journal of Experimental Medicine (1994)

The contribution of major histocompatibility complex (MHC) class I-peptide affinity to immunodominance of particular peptide antigens (Ags) in the class I-restricted cytotoxic T lymphocyte (CTL) response is not clearly established. Therefore, we have compared the H-2Kb-restricted binding and presentation of the immunodominant ovalbumin (OVA)257-264 (SIINFEKL) determinant to that of a subdominant OVA determinant OVA55-62 (KVVRFDKL). Immunodominance of OVA257-264 was not attributable to the specific T cell repertoire but correlated instead with more efficient Ag presentation. This enhanced Ag presentation could be accounted for by the higher affinity of Kb/OVA257-264 compared with Kb/OVA55-62 despite the presence of a conserved Kb-binding motif in both peptides. Kinetic binding studies using purified soluble H-2Kb molecules (Kbs) and biosensor techniques indicated that the Kon for association of OVA257-264-C6 and Kbs at 25 degrees C was integral of 10-fold faster (5.9 x 10(3) M-1 s-1 versus 6.5 x 10(2) M-1 s-1), and the Koff approximately twofold slower (9.1 x 10(-6) s-1 versus 1.6 x 10(-5) s-1), than the rate constants for interaction of OVA55-62-C6 and Kbs. The association of these peptides with Kb was significantly influenced by multiple residues at presumed nonanchor sites within the peptide sequence. The contribution of each peptide residue to Kb-binding was dependent upon the sequence context and the summed contributions were not additive. Thus the affinity of MHC class I-peptide binding is a critical factor controlling presentation of peptide Ag and immunodominance in the class I-restricted CTL response.
Cardiopulmonary resuscitation: who makes the decision?
Authors: M E Hill, G MacQuillan, M Forsyth, D A Heath
Journal: BMJ (1994)

Recent guidelines suggested that cardiopulmonary resuscitation should not be given (a) when a patient competent to give informed consent does not wish to have it, (b) when a patient is not competent to give consent and resuscitation is considered to be against his or her best interests, or (c) when resuscitation would probably not be successful.1 Attempts are made, however, to resuscitate patients with little prospect of recovery,*RF 2-4* and few doctors in Britain ascertain whether a patient wishes to be resuscitated.

We explored doctors' views on resuscitation and determined if it was possible to ask patients whether they would wish to be resuscitated.

A questionnaire was sent to 80 hospital doctors to establish who took …
Programs, models, theories, and reality
Authors: Robert I. Damper
Journal: Behavioral and Brain Sciences (2001)

The question "Are 'biorobots' good models of biological behaviour?" can be seen as a specific instance of a more general question about the relation between computer programs and models, between models and theories, and between theories and reality. This commentary develops a personal view of these relations, from an antirealism perspective. Programs, models, theories and reality are separate and distinct entities which may converge in particular cases but should never be confused.
Delayed cancer results "due to apathy"
Authors: Z. Kmietowicz
Journal: BMJ (2000)

Patients with cancer from all over England have been subjected to a “potentially unsafe” testing service at a leading bone cancer centre for at least five years, waiting for up to a year to find out if their treatment has been successful, according to a report.

The Royal National Orthopaedic Hospital (RNOH) NHS Trust in north west London, which received referrals from trusts throughout England, has been at the centre of a row over delayed test …
Utilisation du magnetophone en psychothérapie
Authors: N.N. Dracoulides
Journal: Psychotherapy and Psychosomatics (1965)

Research Articles| February 11 2010 Utilisation du magnétophone en psychothérapie Subject Area: Psychiatry and Psychology N.N. Dracoulides N.N. Dracoulides Athèns Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1965) 13 (6): 466–476. https://doi.org/10.1159/000285805 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation N.N. Dracoulides; Utilisation du magnétophone en psychothérapie. Psychother Psychosom 1 June 1965; 13 (6): 466–476. https://doi.org/10.1159/000285805 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1965Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Raspail: Scientist and Reformer
Authors: Lester S. King
Journal: JAMA (1968)

F.-V. Raspail (1794-1878), although not well known to most physicians, is nevertheless an extraordinary figure, of great significance in medicine, science, politics, and sociology. A lifelong rebel, contentious and mistrustful, he could not accept authority, and he had a rather difficult personality. Nevertheless his achievements were great. His early adult life he devoted intensely to botanic science, with great skill in microscopy at a time when the microscope had not yet reached its adequate development. There is no question but that he described the cell and its contents 12 years before Schleiden and Schwann. Furthermore, he was virtually the founder of histochemistry, and used chemical techniques to identify chemical substances in cells. However, with the political commotions in France in 1830 he became involved in politics, to the detriment of science. He never took a higher degree and was never licensed to practice medicine but he devised his own medical
Multiple sclerosis in the African.
Authors: R M Foster, J R Harries
Journal: BMJ (1970)

Medical Memoranda MBAJOLwas then so far advanced as to make surgery extremely difficult.The hypertension found in the upper half of the stomach and lower oesophagus was probably due to (1) the increased inflow from the large spleen and its enlarged tortuous artery;(2) obstruction of the left gastric, splenic, and left gastroepi- ploic veins by fibrosis; and (3) high pressure in the normally low-pressure azygos system, since these veins were acting as collaterals for the venous return from the legs.No previous report of this complication could be found on reviewing the literature.
Funding the NHS: Is the NHS sustainable?
Authors: A. Harrison, J. Dixon, B. New, K. Judge
Journal: BMJ (1997)

<h3>Abstract</h3> The survival of the NHS lies largely in the hands of government, and this article suggests steps that it should take to deal with pressures on the NHS in terms of funding, managing efficiency, and demands. Changes to the system of funding may be unfeasible, but management could be improved by research to allow greater understanding of the local effects of national policies. Alternatively health authorities could be given more freedom to manage funds, although this would have to be accompanied by stiff sanctions for those who failed. Demand could be contained by strengthening policies to ensure that new technologies are cost effective. The government could try to reduce demands arising from increased expectations by encouraging informed public debate about priorities and influencing the availability of private health care. All these efforts should be guided by the values underpinning the NHS, which should be debated and decided collectively and confirmed in a new charter for NHS9s 50th anniversary in 1998.
Modeling the Demographic Effects of Endocrine Disruptors
Authors: William S.C. Gurney
Journal: Environmental Health Perspectives (2005)

In this article we describe a series of strategic models of populations and individuals subject to challenge by endocrine disruptors. These models are not designed to be fitted to detailed data on specific species but rather are intended to provide general insights on the relative importance of different demographic mechanisms in the population context. Therefore, the models contain the minimum necessary biological detail, but in recompense they are highly accessible to mathematical analysis. We show that, over a range of models with contrasting biological detail, population viability is controlled by the number of female offspring that result from the average female’s lifetime reproductive activity. Thus, male fertility changes have little effect at the population level until they become severe enough to reduce this average female output. We argue that in many circumstances endocrine disruptors are likely to produce directly deleterious effects on female fecundity at levels far below those required to reduce male fertility to dangerously low levels. Finally, we formulate a simple model of individual energetics that we argue can form the basis of a strategic discussion of the likely sensitivity of female demographic parameters to chemically induced changes in physiological function.
Long survival after excision of a primary malignant melanoma of the oesophagus.
Authors: F C Hamdy, J H Smith, A Kennedy, J A Thorpe
Journal: Thorax (1991)

A woman who had a large primary malignant melanoma of the oesophagus, with evidence of submucosal invasion and several local metastases, underwent resection two years after the onset of retrosternal pain and has survived for 12 years with no recurrence.
Pulmonary Infection After TB
Authors: M. J. Friedrich
Journal: JAMA (2012)

More than 1 million people who are treated successfully for pulmonary tuberculosis (TB) eventually develop a fungal infection called chronic pulmonary aspergillosis (CPA), report researchers in the United Kingdom and Canada (Denning DW et al. Bull World Health Organ. 2011;89[12]:864-872).
The epidermal cell kinetics of the erythrokeratodermas
Authors: I. RALFS, R. P. R. DAWBER, T. J. RYAN, N. A. WRIGHT
Journal: British Journal of Dermatology (1982)

The cell proliferation kinetics of the genodermatoses, erythrokeratoderma variabilis (EKV) and symmetrical progressive erytbrokeratoderma (SPE), were studied using flash labelling studies and cell production rates using vincristine. In EKV the results indicated a mildly hyperproliferative state, while in SPE the results, although variable, showed a prominent epidermal hyperproliferation.
A memorable patient: The senior citizen
Authors: D. Hopton
Journal: BMJ (1998)

The little elderly lady was admitted because of anal pain. As the surgical registrar on call I went to the ward after the operating list to see what problem patients had been admitted.

The staff nurse said: “The little old lady refuses treatment and says she wants to die.” So I went to talk to her. She was 75, lived alone, and had no relatives. She had suffered with pain in her bottom for weeks …
Failure to Rescue
Authors: Philip H. Pucher, Rajesh Aggarwal
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Reviewer acknowledgment 2015
Authors: Otis W. Brawley, Ted Gansler
Journal: CA A Cancer Journal for Clinicians (2015)

The Editors of CA depend on the wisdom and advice of many experts in deciding which topics to pursue, which manuscripts to publish, and what modifications to make to ensure medical and scientific accuracy and suitability for our readers. We thank our Deputy Editor and Associate Editors, who have performed these services for us in the past year. We are also greatly indebted to the expertise, dedication, and expeditious response of the following individuals for reviewing at least one and, in some cases, many manuscripts for the journal from July 1, 2014, to June 30, 2015. Abrams, Donald Ademuyiwa, Foluso Ahles, Tim Bandera, Elisa Brenner, Dean Clarke, Christina Cullen, Kevin Czito, Brian Daeninck, Paul Dancey, Janet Dizon, Don Donovan, Kristine Emberton, Mark Escalante, Carmen Foxhall, Lewis Gallagher, Thomas Gillespie, Theresa Goldman, Mindy Goodman, Martin Greenberg, Donna Grossmann, Allie Hannon, Peggy Hillyer, Grace Hoffman, Richard Holmes-Rovner, Margaret Hong, Angela Islami, Farhad Jabson, Jennifer Jagannath, Sundar Kamen, Charles Krebs, Linda Krychman, Michael Lawrentschuk, Nathan Lee, Byung-Boong Lentzsch, Suzanne Levetown, Marcia Levine, Edward Lyman, Gary Mandrell, Belinda Marks, Leonard McCullough, Marjorie Mclaughlin, Sarah Palefsky, Joel Paskett, Electra Piper, Margaret Potter, John Reisfield, Gary Roblin, Douglas Rocco, James Rubnitz, Jeffrey Russell, Christy Salner, Andrew Schnitt, Stuart Steinherz, Peter Steyerberg, Ewout Valentine, Alan Vardy, Janette Volk, Robert Wolf, Holly Wolfe, Joanne Zimmermann, Camilla
Efficacy and Tolerability of Long-Acting Injectable Naltrexone for Alcohol Dependence
Authors: James C. Garbutt, Henry R. Kranzler, Stephanie S. O’Malley, David R. Gastfriend, Helen M. Pettinati, Bernard L. Silverman, John W. Loewy, Elliot W. Ehrich, for the Vivitrex Study Group
Journal: JAMA (2005)

Alcohol dependence is a common disorder associated with significant morbidity and mortality. Naltrexone, an opioid antagonist, has been shown to be effective for treatment of alcohol dependence. However, adherence to daily oral pharmacotherapy can be problematic, and clinical acceptance and utility of oral naltrexone have been limited.To determine efficacy and tolerability of a long-acting intramuscular formulation of naltrexone for treatment of alcohol-dependent patients.A 6-month, randomized, double-blind, placebo-controlled trial conducted between February 2002 and September 2003 at 24 US public hospitals, private and Veterans Administration clinics, and tertiary care medical centers. Of the 899 individuals screened, 627 who were diagnosed as being actively drinking alcohol-dependent adults were randomized to receive treatment and 624 received at least 1 injection.An intramuscular injection of 380 mg of long-acting naltrexone (n = 205) or 190 mg of long-acting naltrexone (n = 210) or a matching volume of placebo (n = 209) each administered monthly and combined with 12 sessions of low-intensity psychosocial intervention.The event rate of heavy drinking days in the intent-to-treat population.Compared with placebo, 380 mg of long-acting naltrexone resulted in a 25% decrease in the event rate of heavy drinking days (P = .02) [corrected] and 190 mg of naltrexone resulted in a 17% decrease (P = .07). Sex and pretreatment abstinence each showed significant interaction with the medication group on treatment outcome, with men and those with lead-in abstinence both exhibiting greater treatment effects. Discontinuation due to adverse events occurred in 14.1% in the 380-mg and 6.7% in the 190-mg group and 6.7% in the placebo group. Overall, rate and time to treatment discontinuation were similar among treatment groups.Long-acting naltrexone was well tolerated and resulted in reductions in heavy drinking among treatment-seeking alcohol-dependent patients during 6 months of therapy. These data indicate that long-acting naltrexone can be of benefit in the treatment of alcohol dependence.
Enhanced External Counterpulsation Improves Peripheral Artery Flow-Mediated Dilation in Patients With Chronic Angina
Authors: Randy W. Braith, C. Richard Conti, Wilmer W. Nichols, Calvin Y. Choi, Matheen A. Khuddus, Darren T. Beck, Darren P. Casey
Journal: Circulation (2010)

Background— Mechanisms responsible for anti-ischemic benefits of enhanced external counterpulsation (EECP) remain unknown. This was the first randomized sham-controlled study to investigate the extracardiac effects of EECP on peripheral artery flow-mediated dilation. Methods and Results— Forty-two symptomatic patients with coronary artery disease were randomized (2:1 ratio) to thirty-five 1-hour sessions of either EECP (n=28) or sham EECP (n=14). Flow-mediated dilation of the brachial and femoral arteries was performed with the use of ultrasound. Plasma levels of nitrate and nitrite, 6-keto-prostaglandin F 1α , endothelin-1, asymmetrical dimethylarginine, tumor necrosis factor-α, monocyte chemoattractant protein-1, soluble vascular cell adhesion molecule, high-sensitivity C-reactive protein, and 8-isoprostane were measured. EECP increased brachial (+51% versus +2%) and femoral (+30% versus +3%) artery flow-mediated dilation, the nitric oxide turnover/production markers nitrate and nitrite (+36% versus +2%), and 6-keto-prostaglandin F 1α (+71% versus +1%), whereas it decreased endothelin-1 (−25% versus +5%) and the nitric oxide synthase inhibitor asymmetrical dimethylarginine (−28% versus +0.2%) in treatment versus sham groups, respectively (all P &lt;0.05). EECP decreased the proinflammatory cytokines tumor necrosis factor-α (−16% versus +12%), monocyte chemoattractant protein-1 (−13% versus +0.2%), soluble vascular cell adhesion molecule-1 (−6% versus +1%), high-sensitivity C-reactive protein (−32% versus +5%), and the lipid peroxidation marker 8-isoprostane (−21% versus +1.3%) in treatment versus sham groups, respectively (all P &lt;0.05). EECP reduced angina classification (−62% versus 0%; P &lt;0.001) in treatment versus sham groups, respectively. Conclusions— Our findings provide novel mechanistic evidence that EECP has a beneficial effect on peripheral artery flow-mediated dilation and endothelial-derived vasoactive agents in patients with symptomatic coronary artery disease.
Gastrointestinal Bleeding with Cirrhosis
Authors: Thomas C. Merigan, Robert M. Hollister, Paul F. Gryska, George W. B. Starkey, Charles S. Davidson
Journal: New England Journal of Medicine (1960)

FEW problems tax the clinician's diagnostic and therapeutic ingenuity as much as the patient with cirrhosis in whom gastrointestinal hemorrhage develops. Frequently, such a patient presents evidence suggesting any or all of the three lesions most commonly responsible for gastrointestinal bleeding: gastritis; peptic ulceration; and esophageal varices.1 2 3 The coexistence of two or all three of these lesions is frequently encountered at the Boston City Hospital. One of the reasons for this is the great frequency of alcoholism and cirrhosis in patients admitted to the hospital.4 It has been reported that a high percentage of patients with chronic alcoholism may have . . .
The Initial Attack of Acute Rheumatic Fever During Childhood in North India
Authors: SHYAMAL K. SANYAL, MOHINDER K. THAPAR, SYED H. AHMED, VIJAYA HOOJA, PROMILA TEWARI
Journal: Circulation (1974)

A prospective study was done to determine the clinical profile of first attacks of acute rheumatic fever in children in North India. Unlike other reports, the clinical profile described here closely resembles the spectrum prevalent in the West. Arthritis, the most common manifestation, was seen in 66.6% of the 102 patients, chorea in 20.7%, and carditis in 33.7%. Carditis was considered mild in 22 patients and severe in 12; a persistent elevation of sleeping pulse rate and mitral regurgitation was noted in each case. Patients with severe carditis also had significant cardiomegaly and apical mid-diastolic murmur. Two patients with severe carditis developed congestive heart failure; one of them had pericarditis as well. Murmur of aortic origin was not noted in this series. One patient with severe carditis died from the disease. Erythema marginatum was noted in two, both of whom had severe carditis. There were two instances of subcutaneous nodules, one with and one without carditis. The close similarity of these results with those in the West is attributed to the prospective design of the study, analysis of first attacks only and survey of a general pediatric population for all manifestations suggestive of the disease.
Prenatal Diagnosis — When and How?
Authors: Lawrence D. Platt, Dru E. Carlson
Journal: New England Journal of Medicine (1992)

Advances in prenatal diagnosis provide new opportunities for patients and their physicians to distinguish the abnormal from the normal fetus. Demands from women to learn about their fetuses earlier in pregnancy have pushed investigators to identify new methods that are useful in the first trimester. The prenatal diagnosis of many disorders, such as the fragile X syndrome, cystic fibrosis, hemoglobinopathies, inborn errors of metabolism, and hundreds of mapped inherited syndromes, is possible today with the use of molecular techniques. However, the detection of Down's syndrome is still the primary reason women seek prenatal diagnosis. Parental decisions on how to respond . . .
601 Anti-viral activity of VX-950 resolves expression of an HCV-associated gene signature
Authors: R. Ramachandran, B. Hare, K. Kelliher, J. Randle, P. Caron, M. Harding, H. Reesink, S. Zeuzem, L. McNair, S. Purdy, J. Alam, M. Botfield
Journal: Journal of Hepatology (2006)