tbuckley/cabot-search huggingface dataset:
Weekend Admissions and Increased Risk for Mortality: Less Urgent Treatments Only?—Reply
Authors: William L. Palmer, Alex Bottle, Charlie Davie, Charles A. Vincent, Paul Aylin
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
“Writing Scientific Papers in English”
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1975)

I fear writing a book on how to write. Especially if the topic is medical writing. The author is so vulnerable, for even if he avoids obvious grammatical errors such as using periods to set off a non-sentence, and even if he keeps his peace with Fowler, Gowers and all the rest, he still may offend some stylistic purists by, for example, beginning an editorial with the first person singular. Furthermore, my editorials are carefully screened, as were Dr. Joseph Garland's before me, by the Journal's stylistic master, Senior Assistant Editor Robert O'Leary. It is he who deletes various infelicities . . .
Nanocrystal-based per-oral itraconazole delivery: Superior in vitro dissolution enhancement versus Sporanox® is not realized in in vivo drug absorption
Authors: Annika Sarnes, Miia Kovalainen, Merja R Häkkinen, Timo Laaksonen, Johanna Laru, Juha Kiesvaara, Jukka Ilkka, Olli Oksala, Seppo Rönkkö, Kristiina Järvinen, Jouni Hirvonen, Leena Peltonen
Journal: Journal of Controlled Release (2014)
Evaluation of Myocardial Metabolism in Ischemic Heart Disease
Authors: RICHARD GORLIN
Journal: Circulation (1969)

Metabolism of the human heart during myocardial infarction may be studied by means of arterial and coronary sinus catheterization at little risk, but definite inconvenience. Ischemia has been readily detected through myocardial production or release of lactate, potassium, hydrogen, and certain enzymes. These findings may be of help in identifying the presence of acute myocardial injury or infarction and in evaluation of applied therapy. Other studies, particularly of metabolized substrates, including oxygen, have been less rewarding. The patchy nature of coronary atherosclerosis and its partial compensation by collateral vessels renders coronary venous inflow nonuniform. This makes interpretation of the meaning of the concentration of substances contained within the coronary venous effluent extremely difficult. Multiple-site venous sampling is particularly helpful in overcoming this inherent defect in the method.
Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
Authors: Jiusong Sun, Galina K. Sukhova, Min Yang, Paul J. Wolters, Lindsey A. MacFarlane, Peter Libby, Chongxiu Sun, Yadong Zhang, Jian Liu, Terri L. Ennis, Rebecca Knispel, Wanfen Xiong, Robert W. Thompson, B. Timothy Baxter, Guo-Ping Shi
Journal: Journal of Clinical Investigation (2007)

Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of which contribute to aortic dilatation. This study demonstrates that mast cells, key participants in human allergic immunity, participate in AAA pathogenesis in mice. Mast cells were found to accumulate in murine AAA lesions. Mast cell-deficient KitW-sh/KitW-sh mice failed to develop AAA elicited by elastase perfusion or periaortic chemical injury. KitW-sh/KitW-sh mice had reduced aortic expansion and internal elastic lamina degradation; decreased numbers of macrophages, CD3+ T lymphocytes, SMCs, apoptotic cells, and CD31+ microvessels; and decreased levels of aortic tissue IL-6 and IFN-gamma. Activation of mast cells in WT mice via C48/80 injection resulted in enhanced AAA growth while mast cell stabilization with disodium cromoglycate diminished AAA formation. Mechanistic studies demonstrated that mast cells participated in angiogenesis, aortic SMC apoptosis, and matrix-degrading protease expression. Reconstitution of KitW-sh/KitW-sh mice with bone marrow-derived mast cells from WT or TNF-alpha-/- mice, but not from IL-6-/- or IFN-gamma-/- mice, caused susceptibility to AAA formation to be regained. These results demonstrate that mast cells participate in AAA pathogenesis in mice by releasing proinflammatory cytokines IL-6 and IFN-gamma, which may induce aortic SMC apoptosis, matrix-degrading protease expression, and vascular wall remodeling, important hallmarks of arterial aneurysms.
Adenovirus-Mediated Overexpression of <i>O</i> -GlcNAcase Improves Contractile Function in the Diabetic Heart
Authors: Ying Hu, Darrell Belke, Jorge Suarez, Eric Swanson, Raymond Clark, Masahiko Hoshijima, Wolfgang H. Dillmann
Journal: Circulation Research (2005)

To examine whether excessive protein O -GlcNAcylation plays a role in the dysfunction of the diabetic heart, we delivered adenovirus expressing O -GlcNAcase (Adv-GCA) into the myocardium of STZ-induced diabetic mice. Our results indicated that excessive cellular O -GlcNAcylation exists in the diabetic heart, and that in vivo GCA overexpression reduces overall cellular O -GlcNAcylation. Myocytes isolated from diabetic hearts receiving Adv-GCA exhibited improved calcium transients with a significantly shortened T decay ( P &lt;0.01) and increased sarcoplasmic reticulum Ca 2+ load ( P &lt;0.01). These myocytes also demonstrated improved contractility including a significant increase in +dL/dt and −dL/dt and greater fractional shortening as measured by edge detection ( P &lt;0.01). In isolated perfused hearts, developed pressure and −dP/dt were significantly improved in diabetic hearts receiving Adv-GCA ( P &lt;0.05). These hearts also exhibited a 40% increase in SERCA2a expression. Phospholamban protein expression was reduced 50%, but the phosphorylated form was increased 2-fold in the diabetic hearts receiving Adv-GCA. We conclude that excess O -GlcNAcylation in the diabetic heart contributes to cardiac dysfunction, and reducing this excess cellular O -GlcNAcylation has beneficial effects on calcium handling and diabetic cardiac function.
ACE inhibitors and angiotensin II receptor antagonists independently but synergistically increase coronary blood flow and attenuates the severity of contractile and metabolic dysfunction in ischemic hearts
Authors: Masafumi Kitakaze, Koichi Node, Seiji Takashima, Tetsuo Minamino, Hiroshi Asanuma, Masanori Asakura, Jiyoong Kim, Shoji Sanada, Hisakazu Ogita, Yoshihiro Asano, Yasunori Shintani, Masatsugu Hori
Journal: Journal of the American College of Cardiology (2002)
THE PRESENT STATUS OF PREVENTIVE MEANS AGAINST THE SPREAD OF TUBERCULOSIS IN THE VARIOUS STATES OF THE UNION CRITICALLY REVIEWED.
Authors: S. A. KNOPF
Journal: JAMA (1897)

In order to ascertain the exact condition of prophylaxis in regard to tuberculosis, I have addressed letters of inquiry to all the secretaries of the State boards of health of all the States and Territories of the Union, and to the health officers of forty of the largest cities. To all the gentlemen who by their prompt replies so kindly aided me in compiling this report, I wish to express my sincere thanks and appreciation. Here are the results of my inquiries: <h3>Alabama.</h3> —No laws or regulations concerning tuberculosis in man or beast, and no circulars issued. <h3>Arkansas.</h3> —No laws, regulations or circulars concerning tuberculosis. Dr. Jennings, the executive officer, writes that the State not having made any appropriation, the board is handicapped for want of funds. <h3>California.</h3> —Good bovine laws and regulations, circular issued on consumption. <h3>Colorado.</h3> —Good bovine laws and regulations and a special circular, "How to prevent
Metastability Behavior of Supersaturated Bile
Authors: R. Thomas Holzbach
Journal: Hepatology (1984)

Major discrepancies exist between both the degree (or cholesterol excess limit) and duration of metastable cholesterol supersaturation in concentrated model biles and native human gallbladder bile. The comparatively reduced metastability of in vitro model systems suggests that a stabilizing factor is absent in these more concentrated systems. In contrast, the metastable supersaturation behavior of the dilute model and hepatic biles is similar particularly with respect to their markedly prolonged metastability, i.e., nucleation time. These observations suggest that changes in the lipid component alone (e.g., structural alterations resulting from dilution) could account for the similarity. The structural component in hepatic biles and in comparable dilute model systems appears to be small unilamellar vesicles which have an unusual duration of metastability and a high capacity for cholesterol transport. In this sense, metastability properties characteristic of pure micellar systems are neither observed nor to be expected in human hepatic bile and are only partially responsible for metastability in gallbladder bile.
Levels of soluble HLA-I and β2M in patients with acute myeloid leukemia and advanced myelodysplastic syndrome: association with clinical behavior and outcome of induction therapy
Authors: M Albitar, M Johnson, K A Do, A Day, I Jilani, S Pierce, E Estey, H Kantarjian, M Keating, S Verstovsek, S O'Brien, F J Giles
Journal: Leukemia (2007)
Selective stimulation of parasympathetic nerve fibers to the human sinoatrial node.
Authors: M D Carlson, A S Geha, J Hsu, P J Martin, M N Levy, G Jacobs, A L Waldo
Journal: Circulation (1992)

BACKGROUND In animals, parasympathetic nerve fibers that innervate the sinoatrial node can be selectively stimulated to increase atrial cycle length. These nerve fibers course through an epicardial fat pad at the margin of the right superior pulmonary vein, the superior vena cava, and the right atrium. We hypothesized that similar nerves exist and can be selectively stimulated in humans. METHODS AND RESULTS Microscopic examination of fat pads excised from the margin of the right superior pulmonary vein, the superior vena cava, and the right atrium during two human autopsies revealed the presence of nerve fibers and ganglia. We electrically stimulated this epicardial fat pad in 16 patients during cardiac surgery. The fat pads were stimulated with continuous-pulse trains for 15 seconds via a hand-held bipolar electrode using constant current (10-15 mA), constant pulse width (0.02-0.05 msec), and at 6.6, 10, 20, 25, and 30 Hz. The mean atrial cycle length +/- 1 SEM increased from 734 +/- 34 msec at baseline to a maximum of 823 +/- 61 msec at 6.6 Hz, 1,167 +/- 125 msec at 10 Hz, 1,734 +/- 281 msec at 20 Hz, 2,993 +/- 661 msec at 25 Hz, and 2,461 +/- 668 msec at 30 Hz during nerve stimulation. Linear regression analysis showed that the response of atrial cycle length to sinoatrial parasympathetic nerve stimulation was frequency dependent. The maximum response and complete decay of the response occurred within 4-8 seconds of initiation or termination of sinoatrial parasympathetic nerve stimulation. Atrioventricular conduction time and the PR interval did not change during sinoatrial parasympathetic nerve stimulation, even when the atria were paced at the baseline heart rate. CONCLUSIONS Electrical stimulation of parasympathetic nerve fibers in a fat pad near the sinoatrial node increased atrial cycle length without affecting atrioventricular nodal conduction. This is the first study in which such nerve fibers that innervate the sinoatrial node have been selectively stimulated in humans.
CD44 Attenuates Activation of the Hippo Signaling Pathway and Is a Prime Therapeutic Target for Glioblastoma
Authors: Yin Xu, Ivan Stamenkovic, Qin Yu
Journal: Cancer Research (2010)

Glioblastoma multiforme (GBM) is the most aggressive brain tumor that, by virtue of its resistance to chemotherapy and radiotherapy, is currently incurable. Identification of molecules whose targeting may eliminate GBM cells and/or sensitize glioblastoma cells to cytotoxic drugs is therefore urgently needed. CD44 is a major cell surface hyaluronan receptor and cancer stem cell marker that has been implicated in the progression of a variety of cancer types. However, the major downstream signaling pathways that mediate its protumor effects and the role of CD44 in the progression and chemoresponse of GBM have not been established. Here we show that CD44 is upregulated in GBM and that its depletion blocks GBM growth and sensitizes GBM cells to cytotoxic drugs in vivo. Consistent with this observation, CD44 antagonists potently inhibit glioma growth in preclinical mouse models. We provide the first evidence that CD44 functions upstream of the mammalian Hippo signaling pathway and that CD44 promotes tumor cell resistance to reactive oxygen species-induced and cytotoxic agent-induced stress by attenuating activation of the Hippo signaling pathway. Together, our results identify CD44 as a prime therapeutic target for GBM, establish potent antiglioma efficacy of CD44 antagonists, uncover a novel CD44 signaling pathway, and provide a first mechanistic explanation as to how upregulation of CD44 may constitute a key event in leading to cancer cell resistance to stresses of different origins. Finally, our results provide a rational explanation for the observation that functional inhibition of CD44 augments the efficacy of chemotherapy and radiation therapy.
Seminal plasma anaphylaxis: successful pregnancy after intravaginal desensitization and immunodetection of allergens
Authors: Jung Won. Park, Si Hwan. Ko, Cheol Woo. Kim, Chein‐soo. Hong, Sang Wook Bae
Journal: Allergy (1999)

For seminal plasma‐allergic patients to achieve pregnancy, immunotherapy or artificial insemination is recommended. However, these modalities require complicated procedures. We recently treated a patient with human seminal plasma anaphylaxis who was successfully desensitized after intravaginal rush desensitization and became spontaneously pregnant. She had a healthy full‐term infant. With immunoblotting, we identified multiple allergens in her husband's seminal plasma, with molecular masses such as 100, 75, 65, 50, 40, 38, 33, 20, and 18 kDa, and the pattern of immunoblotting did not change after desensitization. We found not only specific antibodies to the seminal plasma of the patient's partner, but also common antibodies to both the partner's and the control specimen. Our results suggest that intravaginal desensitization might be an effective and convenient initial approach for patients who want to achieve pregnancy, and also confirm the presence of both the specific and shared common allergens in the seminal plasmas of the patient's partner and the control subject.
Call of the curlew
Authors: Des Spence
Journal: BMJ (2007)

My face clung to the seats as I crossed the Pentland Firth for the first time. As the boat lurched and rolled again, the sound of cattle, terrified in the hold, resonated throughout the ship. I was unable to raise my head for fear of heaving. The Orcadians, welly booted and boiler suited, laughed and joked through cigarette smoke as they chewed on bacon rolls. I wanted to bawl.

Ten years later I stood on the deck, drenched in sea spay. I chewed a …
Efficacy of Pemetrexed as Second-Line Therapy in Advanced NSCLC after Either Treatment-Free Interval or Maintenance Therapy with Gemcitabine or Erlotinib in IFCT-GFPC 05-02 Phase III Study
Authors: Olivier Bylicki, Céline Ferlay, Christos Chouaid, Armelle Lavolé, Fabrice Barlési, Cathérine Dubos, Virginie Westeel, Jacky Créquit, Roman Corre, Alain Vergnenègre, Isabelle Monnet, Hervé Le Caer, Pierre Fournel, Fabien Vaylet, Lionel Falchero, Michel Poudenx, Pauline Linard, David Pérol, Gérald Zalcman, Maurice Pérol
Journal: Journal of Thoracic Oncology (2013)
Among Middle-income Children In NYC, Neighborhood Reports Of Mouse Sightings Were Associated With Sensitization To Mouse
Authors: M.S. Jackson-Browne, O. Olmedo, A. Divijan, I.F. Goldstein, L. Acosta, A.G. Rundle, R.B. Mellins, J.W. Quinn, F.P. Perera, R.L. Miller, J.S. Jacobson, M.S. Perzanowski
Journal: Journal of Allergy and Clinical Immunology (2012)
Re: Decreasing Women's Anxieties After Abnormal Mammograms: A Controlled Trial
Authors: D. B. Kopans
Journal: JNCI Journal of the National Cancer Institute (2004)

Anyone reading the paper by Barton et al. (1) on decreasing anxiety associated with false-positive mammograms should consider the following points.First, as explained below, there is a greater potential for false-negative mammograms when immediate interpretations are rendered than when they are not.Second, the authors have documented what is intuitively obvious, i.e.,
Photoprotective action of emollients in ultraviolet therapy of psoriasis
Authors: M.J. HUDSON-PEACOCK, B.L. DIFFEY, P.M. FARR
Journal: British Journal of Dermatology (1994)

Journal Article Photoprotective action of emollients in ultraviolet therapy of psoriasis Get access M.J. HUDSON‐PEACOCK, M.J. HUDSON‐PEACOCK Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tune, NKI 4LP, U.K. Search for other works by this author on: Oxford Academic Google Scholar B.L. DIFFEY, B.L. DIFFEY Regional Medical Physics Department, Dryburn Hospital, Durham, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.M. FARR P.M. FARR Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tune, NKI 4LP, U.K. †Correspondence: Dr P.M.Farr. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 3, 1 March 1994, Pages 361–365, https://doi.org/10.1111/j.1365-2133.1994.tb02934.x Published: 01 March 1994 Article history Accepted: 13 August 1993 Published: 01 March 1994
852. Human ANP32B Protein Binds AAV-2 Rep and Increases Viral Replication and rAAV Production
Authors: Gianluca Pegoraro, Alessandro Marcello, Michael P. Myers, Mauro Giacca
Journal: Molecular Therapy (2005)

AAV Rep proteins play a fundamental role at every phase of the viral life cycle and have pleiotropic effects on diverse cellular pathways such as transcription, cell-cycle progression and apoptosis. For these reasons we focused on identifying novel cellular factors that bind Rep and modulate its biological activities. To this aim, we designed and implemented a tagged proteomic approach by expressing a Flag-tagged version of Rep in human cells. Flag-Rep was subsequently purified by affinity chromatography and the identity of several proteins co-purifying with Rep was determined by ESI-MS/MS.
The Provision and Financing of Medical Care for AIDS Patients in US Public and Private Teaching Hospitals
Authors: Dennis P. Andrulis
Journal: JAMA (1987)

The National Association of Public Hospitals and the Association of American Medical Colleges' Council of Teaching Hospitals conducted a detailed survey on hospital care to patients with acquired immunodeficiency syndrome (AIDS) in major US public and private teaching institutions in 1985. The 169 hospitals treating patients with AIDS that responded to the survey reported providing inpatient services to 5393 patients with AIDS. These patients accounted for 171205 inpatient days and 8806 inpatient admissions, with an average length of stay of 19 days. The average costs and revenue for patients with AIDS per day were $635 and $482, respectively, with Medicaid representing the most frequent third-party payer. The average inpatient cost per patient per year was $20 320. Using Centers for Disease Control estimates of 18 720 patients diagnosed as having AIDS and alive during any part of 1985, we estimate that the total cost of inpatient care for patients with AIDS was $380 million for that year. We also found significant regional and ownership differences in source of payment for patients with AIDS and regional differences in revenues received for AIDS treatment. Results indicate that the costs of treating patients with AIDS will profoundly affect major public and private teaching institutions, but that public teaching hospitals in states with restrictive Medicaid programs will be most adversely affected. (<i>JAMA</i>1987;258:1343-1346)
CAROTID APPLANATION TONOMETRY IMPROVES CARDIOVASCULAR RISK PREDICTION SIMILARLY TO CARDIAC AND CAROTID ULTRASONOGRAPHY: A NEW SCREENING TOOL FOR WIDE POPULATIONS OF SUBJECTS AT RISK
Authors: Silvia Denti, Pier Sergio Saba, Giovanni Lorenzoni, Luca Bullitta, Enrico Mura, Antonella Oppo, Antonello Ganau
Journal: Journal of the American College of Cardiology (2011)
Susceptibility Genes for Breast Cancer
Authors: B L Weber
Journal: New England Journal of Medicine (1994)

In an era in which the importance of a scientific advance often appears to be measured by the amount of media coverage it generates, the level of reporting of the recent identification of BRCA1, a susceptibility gene for breast cancer on chromosome 17 and the first such gene to be isolated, suggests that this discovery is the most exciting breakthrough in modern times. Earlier news coverage of the “race” to find BRCA1 was noteworthy for the amount of media attention focused on something that had yet to be accomplished. This general interest in BRCA1 is illustrated by the fact that . . .
Comparison of three doses of ursodeoxycholic acid in the treatment of primary biliary cirrhosis: a randomized trial
Authors: Paul Angulo, E.Rolland Dickson, Terry M Therneau, Roberta A Jorgensen, Coleman Smith, Carolee K DeSotel, Stephen M Lange, Monte L Anderson, Douglas W Mahoney, Keith D Lindor
Journal: Journal of Hepatology (1999)
Auscultation of the Heart
Authors: Rolf M. Gunnar
Journal: JAMA (1967)

The recent advances in correlating physical signs with physiologic events of the heart have created a need for a concise review of the meanings of heart sounds, murmurs, and precordial movements. Dr. Ravin has met this need in this readable book directed to the student and practitioner. Three introductory chapters acquaint the reader with the properties and transmission of sound and with the use and abuse of the stethoscope. In addition, the author introduces a method of recording auscultatory findings which has its major merit in forcing the examiner to be methodical in eliciting the various heart sounds and murmurs. In the next six chapters Dr. Ravin discusses heart sounds and murmurs in relation to their origin and recognition. This, an excellent section for the practitioner, has its weakness for the student or cardiologist since it does not cite references. It would have been helpful to have made specific reference
Child care in general practice. Adoption.
Authors: H. N. Lewis
Journal: BMJ (1965)

The family doctor's concern with adoption may begin when he is consulted by a couple who cannot because of sterility or impotence have children of their own. As he will have tried to help them in overcoming the disability, it is to him that they will naturally turn for advice if they decide to adopt a child. He may be asked to supply a medical report either on the baby who is to be adopted or on the prospective adopting parents. Thereafter he may have the adopted child as a patient and he may be needed not only for physical illness but also for dealing with the emotional difficulties which are prone to occur in an adopted child from time to time.