tbuckley/cabot-search huggingface dataset:
Lymphomatoid granulomatosis complicating other haematological malignancies
Authors: F.M. Muller, S. Lewis-Jones, S. Morley, N. Kernohan, D. MeikleJohn, J.R. Goodlad, A. Evans
Journal: British Journal of Dermatology (2007)

Journal Article Lymphomatoid granulomatosis complicating other haematological malignancies Get access F.M. Muller, F.M. Muller Departments of Dermatology E‐mail: f.muller@nhs.net Search for other works by this author on: Oxford Academic Google Scholar S. Lewis‐Jones, S. Lewis‐Jones Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar S. Morley, S. Morley Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar N. Kernohan, N. Kernohan Pathology Search for other works by this author on: Oxford Academic Google Scholar D. MeikleJohn, D. MeikleJohn Haematology, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.R. Goodlad, J.R. Goodlad Department of Pathology, Western General Hospital, Edinburgh, U.K. Search for other works by this author on: Oxford Academic Google Scholar A. Evans A. Evans Pathology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 2, 1 August 2007, Pages 426–429, https://doi.org/10.1111/j.1365-2133.2007.08038.x Published: 01 August 2007
Abstract 2979: Wolf-Hirschhorn syndrome candidate 1 plays an important role in the pathogenesis of head and neck cancer.
Authors: Vassiliki Saloura, Hyun-Soo Cho, Mark Lingen, Terri Li, Can Gong, Seiwert Tanguy, Ezra Cohen, Ryuji Hamamoto, Yusuke Nakamura
Journal: Cancer Research (2013)

Abstract Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is a histone lysine methyltransferase (HMT) which was initially found to be deregulated in a subset of multiple myeloma cells with the t(4;14) (p16;q32) translocation and poor prognosis. Recently, our group as well as others found that WHSC1 was overexpressed in a variety of tumors, including lung and esophageal squamous cell carcinomas, with low or no expression in normal tissues except the testis. Long-term survival of patients with squamous cell carcinoma of the head and neck (SCCHN) remains poor and thus new therapeutic strategies are urgently needed. Epigenetic alterations have mainly been studied as a potential mechanism of progression from dysplasia to squamous cell carcinoma. Given the promising potential of HMTs as novel drug targets and the aforementioned interesting expression patterns, we further investigated the role of WHSC1 in carcinogenesis through immunohistochemical analysis (IHC) using tissue microarrays of 123 locoregionally advanced SCCHN patients, and 6 samples of fibroepithelial hyperplasia lesions obtained from oral biopsies. We classified its expression levels with a scoring scale of 0 (no expression), +1 (mild), +2 (moderate) or +3 (strong). WHSC1 expression in the nucleus and cytoplasm was moderate (score +2, 37%) or strong (score +3, 38%) in 75% of SCCHN samples, while 25% showed mild (score +1, 24%) or no (score 0, 1%) expression. WHSC1 staining of normal epithelial regions revealed an exclusively nuclear expression pattern in the basal and parabasal layers. This is consistent with reports suggesting a physiologic role of the Wnt-pathway, which was recently found to be induced by WHSC1, in the differentiation process of the squamous epithelium. We also performed Western blot analysis of WHSC1 in 8 SCCHN cells lines, 3 control fibroblast cell lines and 1 keratinocyte cell line. We observed moderate to strong overexpression of WHSC1 in 4 of 8 SCCHN cell lines, while no expression was detected in the normal keratinocytes or the fibroblast cell lines. These findings support a potential role of the WHSC1 pathway in the pathogenesis of SCCHN and provides a new therapeutic avenue for drug discovery in this fatal disease. Citation Format: Vassiliki Saloura, Hyun-Soo Cho, Mark Lingen, Terri Li, Can Gong, Seiwert Tanguy, Ezra Cohen, Ryuji Hamamoto, Yusuke Nakamura. Wolf-Hirschhorn syndrome candidate 1 plays an important role in the pathogenesis of head and neck cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2979. doi:10.1158/1538-7445.AM2013-2979
A Practical Approach to Infectious Diseases
Authors: John Z. Montgomerie
Journal: JAMA (1984)

I began reviewing this book skeptical about the need for an additional book on infectious diseases at the present time but was pleasantly surprised by the amount of new material and the new approach.  The chapters are well written and the editing has resulted in remarkable uniformity. The chapters deal with the clinical approach to the diagnosis and management of infections. The book has covered the major areas in infectious diseases, but I believe a section on infections in the immunosuppressed patient would have been of value. All areas have been well researched and the references are well selected. The physician with an infectious disease problem will use this as an important reference in treatment.  Some readers may be troubled by the way in which the text is tabulated, but I believe this is useful to help organize the information. The print is small, and I am sorry that it
Liver Scan in The Budd-Chiari Syndrome
Authors: Tapan K. Chaudhuri
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The appearance of the liver scan of a patient with proven Budd-Chiari syndrome (BCS) is presented. While the liver scans in cases of hepatic neoplasm show focal defects and those of cirrhosis of liver have been characterized as "shift of colloid"—increased splenic and skeletal uptake of colloid—it is at present premature to characterize the liver scan in BCS, which appears almost the same as that in advanced cirrhosis of liver. In the Figure, the liver scan of a case of BCS (proven by hepatic venogram) shows diminution and irregular distribution of colloid uptake, and increased splenic and bone marrow uptake of colloid. The scan is indistinguishable from that of a patient with advanced cirrhosis of liver. Further studies of scans of more patients with BCS are needed before we can characterize the scan findings in BCS, thus differentiating it from cirrhosis of liver. This report would also
Cryotherapy of PUVA lentigines
Authors: D. LEROY, A. DOMPMARTIN, A. DUBREUIL, S. LOUVET
Journal: British Journal of Dermatology (1996)

PUVA lentigines do not subside after discontinuation of photochemotherapy. Cryotherapy with liquid nitrogen was done on a small area in a patient who presented with numerous PUVA lentigines. Five years after this treatment, the PUVA lentigines had not returned. Cosmelically disturbing PUVA lentigines can be treated with cryotherapy.
Genomewide Association Study of Leprosy
Authors: Fu-Ren Zhang, Wei Huang, Shu-Min Chen, Liang-Dan Sun, Hong Liu, Yi Li, Yong Cui, Xiao-Xiao Yan, Hai-Tao Yang, Rong-De Yang, Tong-Sheng Chu, Chi Zhang, Lin Zhang, Jian-Wen Han, Gong-Qi Yu, Cheng Quan, Yong-Xiang Yu, Zheng Zhang, Ben-Qing Shi, Lian-Hua Zhang, Hui Cheng, Chang-Yuan Wang, Yan Lin, Hou-Feng Zheng, Xi-An Fu, Xian-Bo Zuo, Qiang Wang, Heng Long, Yi-Ping Sun, Yi-Lin Cheng, Hong-Qing Tian, Fu-Sheng Zhou, Hua-Xu Liu, Wen-Sheng Lu, Su-Min He, Wen-Li Du, Min Shen, Qi-Yi Jin, Ying Wang, Hui-Qi Low, Tantoso Erwin, Ning-Han Yang, Jin-Yong Li, Xin Zhao, Yue-Lin Jiao, Li-Guo Mao, Gang Yin, Zhen-Xia Jiang, Xiao-Dong Wang, Jing-Ping Yu, Zong-Hou Hu, Cui-Hua Gong, Yu-Qiang Liu, Rui-Yu Liu, De-Min Wang, Dong Wei, Jin-Xian Liu, Wei-Kun Cao, Hong-Zhong Cao, Yong-Ping Li, Wei-Guo Yan, Shi-Yu Wei, Kui-Jun Wang, Martin L Hibberd, Sen Yang, Xue-Jun Zhang, Jian-Jun Liu
Journal: New England Journal of Medicine (2009)

The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on and the biologic understanding of leprosy. Host genetic factors are thought to influence susceptibility to infection as well as disease progression.We performed a two-stage genomewide association study by genotyping 706 patients and 1225 controls using the Human610-Quad BeadChip (Illumina). We then tested three independent replication sets for an association between the presence of leprosy and 93 single-nucleotide polymorphisms (SNPs) that were most strongly associated with the disease in the genomewide association study. Together, these replication sets comprised 3254 patients and 5955 controls. We also carried out tests of heterogeneity of the associations (or lack thereof) between these 93 SNPs and disease, stratified according to clinical subtype (multibacillary vs. paucibacillary).We observed a significant association (P<1.00x10(-10)) between SNPs in the genes CCDC122, C13orf31, NOD2, TNFSF15, HLA-DR, and RIPK2 and a trend toward an association (P=5.10x10(-5)) with a SNP in LRRK2. The associations between the SNPs in C13orf31, LRRK2, NOD2, and RIPK2 and multibacillary leprosy were stronger than the associations between these SNPs and paucibacillary leprosy.Variants of genes in the NOD2-mediated signaling pathway (which regulates the innate immune response) are associated with susceptibility to infection with M. leprae.
Points: Real and imaginary halitosis
Authors: J. Dunn
Journal: BMJ (1987)

causalgia.Clinical experience suggests that superficial mechanical stimulation of P6 is as effective as elec- trical stimulation, but confirmation by a properly controlled clinical trial is required. Dangers from dissolution of latex in Celestin endo-oesophageal tubeDr A E HANWELL (Keymed, Essex SS2 5QH) writes: Dr S A Hussain and others (14 February, p 413) state, in their report of the dangers of the disintegration of Celestin tubes, that this problem is well recognised, but is it?In addition to the five references listed with the case report we found a further five reports of similar disintegration, going back as far as 1976.'-5 For this period we cannot find a single report of similar problems encountered with a prosthesis constructed from silicone rubber, which is much more resistant to disintegration.6 1 Brown P, Hughes RG.Late complication of endoscopic oeso-
Hereditary renal amyloidosis caused by a new variant lysozyme W64R in a French family
Authors: Sophie Valleix, Séverine Drunat, Jean-Baptiste Philit, Daniel Adoue, Jean-Charles Piette, Dominique Droz, Brigitte MacGregor, Denis Canet, Marc Delpech, Gilles Grateau
Journal: Kidney International (2002)
Enhancing Blood Glucose Awareness in Adolescents and Young Adults With IDDM
Authors: Michael A Nurick, Suzanne Bennett Johnson
Journal: Diabetes Care (1991)

Objective To determine the effectiveness of an intervention program designed to improve blood glucose awareness. Research Design and Methods Eight young-adult outpatients (mean age 22 yr) and six adolescent inpatients (mean age 14.5 yr) with insulin-dependent diabetes mellitus participated in the intervention program. Nine adolescent inpatients (mean age 13.9 yr) served as an untreated comparison group. One adult outpatient with unreliable data was removed. Before treatment, each patient completed a minimum of 40 blood glucose estimations, blood glucose tests, and symptom-rating checklists. Symptoms of hypo- or hyperglycemia were identified for each patient. The three-session intervention focused on internal (e.g., personal symptoms) and external (e.g., timing and amount of insulin, food, and exercise) cues that could be used to enhance blood glucose awareness. At postintervention, patients completed a minimum of 40 additional blood glucose estimates and tests. Comparison subjects completed the pre-postassessments but did not receive the intervention. Results Blood glucose estimation accuracy was evaluated with error grid analysis. All estimated-actual blood glucose values were plotted into one of five zones: accurate estimates (zone A), benign errors (zone B), and clinically dangerous errors (zones C, D, and E). An overall accuracy index (AI) was calculated by subtracting the summed percentage of clinically dangerous estimates (zones C, D, and E) from the percentage of accurate estimates (zone A). At study entry, the adolescent inpatients' mean AI of 7% was significantly poorer than the 32% mean AI exhibited by the outpatient young-adult sample (P &amp;lt; 0.02). At postintervention, the adolescents' mean AI improved to 30% (P &amp;lt; 0.02) and the young adults' mean outpatient AI improved to 45% (P &amp;lt; 0.06). The treated sample as a whole exhibited increased sensitivity to both hypo- (P &amp;lt; 0.005) and hyperglycemia (P &amp;lt; 0.05). Similar improvements did not occur in the untreated comparison sample. Conclusions Adolescents may exhibit poorer blood glucose awareness than adults. Although this intervention program improved blood glucose awareness in both adolescent and adult patients, postintervention blood glucose estimation accuracy remained far from ideal.
African ministers adopt declaration to reduce environmental threats to health
Authors: J. Zarocostas
Journal: BMJ (2008)

Health and environment ministers from African countries adopted a declaration during a conference sponsored by the United Nations in Gabon last week, creating a strategic alliance to reduce environmental threats to human health.

The declaration “is the first step towards saving the lives of millions of people from harmful effects of changes in the environment,” said Luis Sambo, director of the World Health Organization’s Africa regional office. “I am delighted that we have managed to secure political commitment to catalyse institutional changes.”

WHO says that over 23% of all deaths in Africa, estimated at more than 2.4 …
Serotyping for Homotransplantation. XXII, Specificity of Cytotoxic Antibodies Developing after Renal Transplantation
Authors: P. J. Morris, M. R. Mickey, D. P. Singal, P. I. Terasaki
Journal: BMJ (1969)

Cytotoxic antibodies against allogeneic lymphocytes were detected in 13 patients after removal of a renal allograft. Antibodies were not detected in seven patients who had grafts in situ for less than two months, but were detected in 13 out of 17 patients who had grafts in situ for longer than two months. The HL-A specificity of these positive sera was compatible with the HL-A antigen mismatch of the donor-recipient pairs in most instances, providing further evidence that such antibodies result from direct sensitization by the allograft and may play some part in renal allograft rejection.
US drug companies will meet more than half the cost of drug approval
Authors: D. Josefson
Journal: BMJ (2002)

The US Food and Drug Administration and the drug companies it regulates have reached a tentative agreement to increase the fees the companies pay to the FDA—in return for speedier reviews of drug and medical devices.

Although a portion of the increase is to be earmarked for safety monitoring, consumer groups question whether there is an inherent conflict of interests at play, because much of the FDA's funding now comes from the industry it regulates, rather than from an independent third party. Dr Sidney Wolfe, of the consumer group …
Abstract 2561: Genistein restored chemosensitivity to oxaliplatin in gemcitabine resistant pancreatic cancer cells in vitro and in orthotopic xenograft mouse model
Authors: Sanjeev Banerjee, Zhiwei Wang, Asfar Azmi, Dejuan Kong, Aamir Ahmad, Fazlul H. Sarkar
Journal: Cancer Research (2010)

Abstract Chemotherapy remains the main stay for pancreatic cancer (PC) treatment with Gemcitabine showing modest benefit. Oxaliplatin has been used as a second line therapy in combination with gemcitabine but the beneficial effect was mitigated due to ‘off target’ toxicity as well as due to de novo and acquired resistance. However, effort toward restoration of sensitivity of PC cells to low concentrations of oxaliplatin is an emerging area of research. Here we report our in vitro and in vivo preclinical evidence in support of chemo-sensitization of gemcitabine resistant PC cells (Panc-1, Panc-28 and MiaPaCa-2) by a non-toxic chemopreventive agent known as genistein. Genistein pretreatment of PC cells exhibiting moderate (Panc-1, Panc-28) to less gemcitabine sensitivity (MiaPaCa-2) using low concentrations of oxaliplatin resulted in a significant reduction in the viability of cells concomitant with increased apoptosis (p&amp;lt;0.01) occurred in a synergistic manner as assessed by colony formation experiments. Since drug-resistance of PC is allegedly linked with constitutive activation of NF-κB as well as further activation by conventional chemotherapeutic agents including oxaliplatin, our mechanistic showed that inactivation of NF-κB by genistein prior to treatment of cell with oxaliplatin is required for the killing of drug resistant cells, which indeed was consistent with the down- regulation of NF-κB and its downstream anti-apoptotic genes (Bcl-2 XIAP's, survivin) leading to the appearance of cleaved PARP and induction of apoptosis. Most importantly, our in vivo experiments using orthotopic mouse model of pancreatic cancer showed significant reduction in tumor size (p&amp;lt;0.01) and reduction of locoregional lymph node metastasis when genistein was given in combination with oxaliplatin compared to monotherapy. These results were also consistent with inactivation of NF-κB and the down-regulation of NF-kB downstream targets (Bcl-xL, survivin and XIAP), all of which was consistent with in vitro findings. Both in vitro as well as in vivo findings were also consistent with immunohistochemistry findings on proliferation marker (Ki-67), apoptosis (TUNEL) and phospho p-65 immunostaining. From these results, we conclude that our results provide strong in vivo evidence in support of our hypothesis showing that genistein sensitizes drug-resistant pancreatic cancer to oxaliplatin, which is mechanistically linked with inactivation of NF-κB, which could be a useful strategy for the treatment of PC in the future. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2561.
Retrograde vs Conventional Dissection Technique in Pancreaticoduodenectomy
Authors: Hai-Yang Zhou, Yi Wang, Jian Zhang, Can-Ping Ruan, Wei-Jun Wang, Yan-Ping Sun, Zhi-Qian Hu
Journal: JAMA Surgery (2014)

A retrograde dissection technique of pancreaticoduodenectomy in a caudocranial direction has been described recently.Fifteen consecutive patients who underwent retrograde pancreaticoduodenectomy were compared with 15 consecutive patients operated on through a conventional approach. The mean (SD) intraoperative blood loss was 407 (202) mL in the retrograde group compared with 423 (253) mL in the conventional group (P = .84). The mean (SD) operative duration was 255 (57) minutes in the retrograde group compared with 264 (54) minutes in the conventional group (P = .66). The overall morbidity was 7 of 15 patients (47%) in the retrograde group and 6 of 15 (40%) in the conventional group (P > .99). Neither group had a positive resection margin or a perioperative death.The retrograde dissection technique had no significant difference in perioperative outcomes compared with the conventional dissection technique and could serve as an alternative dissection approach in pancreaticoduodenectomy.
Diabetic Ketoacidosis and Alcoholic Ketosis
Authors: MlLFORD FULOP
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 November 1979Diabetic Ketoacidosis and Alcoholic KetosisMlLFORD FULOP, M.D., HENRY D. HOBERMAN, PH.D., M.D.MlLFORD FULOP, M.D., HENRY D. HOBERMAN, PH.D., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-796_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The data in the article "Hyperchloremic Acidosis during the Recovery Phase of Diabetic Ketosis" by Oh and colleagues in the December 1978 issue (1) fit well with our findings in patients with diabetic ketoacidosis (2) (Table 1). There are, however, differences in the pretreatment findings in both Oh's and our patients withdiabeticketoacidosis on the one hand, and those in our patients withalcoholicketosis on the other (3) (Table 1). For the comparisons, we have omitted three of our original 21 patients with alcoholic ketosis (3) whose various blood specimens were not obtained simultaneously. Because...References1. OHCARROLLGOLDSTEINFEIN MHDI. Hyperchloremic acidosis during the recovery phase of diabetic ketosis. Ann Intern Med. 1978;89:925-7. LinkGoogle Scholar2. FULOP M. The ventilatory response in uncomplicated diabetic ketoacidosis. Crit Care Med. 1977;5:190-2. CrossrefMedlineGoogle Scholar3. FULOPHOBERMAN MH. Alcoholic ketosis. Diabetes. 1975;24:785-90. CrossrefMedlineGoogle Scholar4. COOPERMANDAVIDOFFSPARKPALLOTTA MFRJ. Clinical studies of alcoholic ketoacidosis. Diabetes. 1974;23:433-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albert Einstein College of Medicine Bronx, NY 10461 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRenal Disorders and Cardiovascular DiseaseKetone body modulation of ligand-gated ion channelsRenal Disorders and Cardiovascular DiseaseLes pièges de l'acidocétose diabétiqueAlcoholic KetoacidosisAlcoholic KetoacidosisAlcoholic KetoacidosisAlcoholism, ketoacidosis, and lactic acidosisALCOHOL AND TREATMENT OF DIABETESAlcoholic Ketoacidosis: A Case ReportAlcoholic ketoacidosis: an underdiagnosed condition?7Alcoholic ketoacidosis: Clinical and laboratory presentation, pathophysiology and treatmentNutritional and metabolic effects of alcoholAnion Gap and Serum Bicarbonate 1 November 1979Volume 91, Issue 5Page: 796-797KeywordsAlcoholicsBlood Issue Published: 1 November 1979 PDF DownloadLoading ...
Control of Gastric Hyperacidity in Peptic Ulcer
Authors: W. E. Smith
Journal: BMJ (1941)

percentage of deaths as the mice inijected with phenolized saline.Having excluded the possibility of the production of non- specific immunity by bacteria, we found in the second experiment that there was no substantial difference between the resistance of animals in the four groups to subsequent infection with influenza virus.These experiments indicate that the simultaneous applica- tioni of heterogeneous substances had no influence on the production of immunity against influenza virus.REFERENCES
Swollen Painless Knee
Authors: J. P. Lavender
Journal: JAMA (1963)

Dr. James J. Pollard: A 77-year-old white male complained of swelling of the left knee for one and one-half years. This began when he injured his left knee in a fall. There had been a gradual increase of painless swelling which was not incapacitating. X-ray examination done elsewhere following the injury was interpreted as negative. The examination was repeated six months later and at that time an abnormality was questioned and operation recommended, but this was refused. On admission to Massachusetts General Hospital, physical examination showed a massive, fusiform swelling about the left knee and the tissues around the proximal tibia. There was a discrete, painless mass measuring 4 cm by 4 cm attached to the proximal tibia in the popliteal space. The hemoglobin, white blood cell count, sedimentation rate, serum calcium, phosphorus, alkaline phosphatase, and acid phosphatase levels were normal. Interpretation of the knee films (Fig 1 and 2)
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming
Authors: Padraic G Fallon, Takashi Sasaki, Aileen Sandilands, Linda E Campbell, Sean P Saunders, Niamh E Mangan, John J Callanan, Hiroshi Kawasaki, Aiko Shiohama, Akiharu Kubo, John P Sundberg, Richard B Presland, Philip Fleckman, Nobuyoshi Shimizu, Jun Kudoh, Alan D Irvine, Masayuki Amagai, W H Irwin McLean
Journal: Nature Genetics (2009)