tbuckley/cabot-search huggingface dataset:
Hepatic glycosphingolipid deficiency and liver function in mice
Authors: Richard Jennemann, Ulrike Rothermel, Shijun Wang, Roger Sandhoff, Sylvia Kaden, Ruud Out, Theo J. van Berkel, Johannes M. Aerts, Karen Ghauharali, Carsten Sticht, Hermann-Josef Gröne
Journal: Hepatology (2010)

Recent studies have reported that glycosphingolipids (GSLs) might be involved in obesity-induced insulin resistance. Those reports suggested that inhibition of GSL biosynthesis in animals ameliorated insulin resistance accompanied by improved glycemic control and decreased liver steatosis in obese mice. In addition, pharmacologic GSL depletion altered hepatic secretory function. In those studies, ubiquitously acting inhibitors for GSL biosynthesis have been used to inhibit the enzyme Ugcg (UDP-glucose:ceramide glucosyltransferase), catalyzing the first step of the glucosylceramide-based GSL-synthesis pathway. In the present study a genetic approach for selective GSL deletion in hepatocytes was chosen to achieve complete inhibition of GSL synthesis and to avoid possible adverse effects caused by Ugcg inhibitors. Using the Cre/loxP system under control of the albumin promoter, GSL biosynthesis in hepatocytes and their release into the plasma could be effectively blocked. Deletion of GSL in hepatocytes did not change the quantity of bile excretion through the biliary duct. Total bile salt content in bile, feces, and plasma from mutant mice showed no difference as compared to control animals. Cholesterol concentration in liver, bile, feces, and plasma samples remained unaffected. Lipoprotein concentrations in plasma samples in mutant animals reached similar levels as in their control littermates. No alteration in glucose tolerance after intraperitoneal application of glucose and insulin appeared in mutant animals. A preventive effect of GSL deficiency on development of liver steatosis after a high-fat diet was not observed. Conclusion : The data suggest that GSL in hepatocytes are not essential for sterol, glucose, or lipoprotein metabolism and do not prevent high-fat diet-induced liver steatosis, indicating that Ugcg inhibitors exert their effect on hepatocytes either independently of GSL or mediated by other (liver) cell types. Hepatology 2010
Communications to an antenatal clinic.
Authors: J A Heward, M Clarke
Journal: BMJ (1976)

When referring pregnant women to an antenatal clinic many general practitioners and midwives presented details of their care in an incomplete and inconsistent manner. As a result, hospital staff often had insufficient basic data from which to work. We recommend that those providing care decide what information they need and make the rationale of collecting this information the subject of a well-evaluated local education programme.
Loss of wild-type carrier-mediatedL-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice
Authors: Koichi Yokogawa, Masayuki Yonekawa, Ikumi Tamai, Rikiya Ohashi, Yasuaki Tatsumi, Yasuhiko Higashi, Masaaki Nomura, Noriyoshi Hashimoto, Hiroko Nikaido, Jun-ichiro Hayakawa, Jun-ichi Nezu, Asuka Oku, Miyuki Shimane, Ken-ichi Miyamoto, Akira Tsuji
Journal: Hepatology (1999)

Juvenile visceral steatosis (JVS) mice, which show systemic l -carnitine deficiency, may be an animal model of Reye's syndrome because of its phenotype of fat deposition and mitochondrial abnormalities in the liver. In this study, we compared the characteristics of the L-carnitine transport in isolated hepatocytes from wild-type and JVS mice. The uptake of l -carnitine by wild-type hepatocytes was saturable and the Eadie-Hofstee plot showed 2 distinct components. The apparent Michaelis constant ( K m ) and the maximum transport rate ( V max ) were 4.6 μmol/L and 59.5 pmol/15 min/10 6 cells, respectively, for the high-affinity component, and 404 μmol/L and 713 pmol/15 min/10 6 cells, respectively, for the low-affinity component. The high-affinity l -carnitine uptake occurred via an active carrier-mediated transport mechanism, which is characterized by Na + -, energy-, and pH-dependency. On the other hand, the high-affinity uptake was absent in JVS hepatocytes, and the values of K m and V max for the low-affinity uptake were 475 μmol/L and 557 pmol/15 min/10 6 cells, respectively. The hepatic carnitine transport properties in wild-type hepatocytes were similar to those of high-affinity mouse Octn2-transfected HEK293 cells. This study suggests that Octn2-type carnitine transporter is dysfunctional in hepatocytes of JVS mice.
Zollinger-Ellison Syndrome: Calcium, Secretin, Gastrin
Authors: CARL S. ALEXANDER
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 April 1975Zollinger-Ellison Syndrome: Calcium, Secretin, GastrinCARL S. ALEXANDER, M.D.CARL S. ALEXANDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-4-591 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent issue Kolts, Herbst, and McGuigan ( 1 ) report on having administered intravenous calcium and secretin to 3 patients with the Zollinger-Ellison syndrome; they confirmed the results of others that administration of these agents resulted in hypergastrinemia. Isenberg and colleagues (2) suggested that the rise in serum calcium might be responsible for the increased level of gastrin. Despite the fact that after secretin infusion the serum calcium appeared to increase 1.0 mg/dl, 1.0 mg/dl, and 0.5 mg/dl in Patients 1, 2, and 3, respectively, Kolts, Herbst, and McGuigan chose to consider the increase as...References1. KOLTS B, HERBST C, and MCGUIGAN J: Calcium and secretin-stimulated gastrin release in the Zollinger-Ellison syndrome. Ann Intern Med 81:758-762, 1974 LinkGoogle Scholar2. ISENBERG J, WALSH J, and PASSARO E: Unusual effect of secretin on serum gastrin, serum calcium, and gastric acid secretion in a patient with suspected Zollinger-Ellison syndrome. Gastroenterology 62:626-631, 1972 CrossrefMedlineGoogle Scholar3. NORDGREN C, NYHUS L, and BOMBECK C: The influenct of calcium on gastric acid secretion and plasma gastrin level in intact and thyroidectomized thyroxin-substituted gastric fistula cats (abstract). Gastroenterology 64:779, 1973 Google Scholar4. BLOOM S, MORTIMER C, and THORNER M: Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet 2:1106-1109, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CARL S. ALEXANDER, M.D.Affiliations: Cardiovascular Section Veterans Administration Hospital Minneapolis, Minnesota 55417 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVISUAL ACUITY MEASUREMENTS WITH GRATING PATTERNSSTREPTOZOTOCIN IN THE ZOLLINGER-ELLISON SYNDROME 1 April 1975Volume 82, Issue 4Page: 591-592KeywordsCalciumGastrinHypergastrinemiaSecretinZollinger Ellison syndrome ePublished: 1 December 2008 Issue Published: 1 April 1975 PDF downloadLoading ...
Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis.
Authors: M Ferretti, V Casini-Raggi, T T Pizarro, S P Eisenberg, C C Nast, F Cominelli
Journal: Journal of Clinical Investigation (1994)

Administration of exogenous interleukin-1 receptor antago- nist (IL-ira) is effective in reducing the severity of disease in animal models of acute inflammation.However, the func- tion of endogenous IL-ira in this process, is not yet known.We investigated the pathophysiological role of IL-ira in a rabbit model of formalin-immune complex colitis.This model has previously been shown to be IL-1 mediated and a reduction in disease severity is observed with exogenous IL-ira treatment.Colonic IL-lra was found to be elevated subsequent to IL-1, and exceeded IL-1 levels 10-fold.Peak levels of IL-ira preceded both the resolution of colitis and a significant decrease in IL-1 production.Administration of specific neutralizing antibodies against rabbit IL-ira in- creased mortality and prolonged intestinal inflammatory re- sponses.A significant increase in IL-1a colonic tissue levels was also measured as a result of exogenous anti-IL-ira treatment.These studies are the first demonstration that endogenous IL-ira may play an important role in regulating the host's inflammatory response by counteracting the deleterious and possibly lethal effects of IL-1 produced during acute inflammation.(
Lifestyle advice from Planet Granada
Authors: A. Tonks
Journal: BMJ (1995)

Does your brain hurt from watching too much intellectually demanding television? Fed up with factual, evidence based programmes, in depth analysis, and cutting edge debate? Granada Television has come up with the perfect solution: half an hour of pure escapism presented by daytime television stars Richard Madeley and Judy Finigan. Viewers of the strangely titled Get a Life! should think twice before getting one in a world where smoking is good, lipstick is fattening, and being a hypochondriac with a morbid fear of cancer is a laugh.

The well meaning pair beam, chuckle, and sympathise their way through a series of unrelated interviews and features apparently put together at random. The tragedy of a family battling …
The White Doves of Mazar
Authors: Tim McBride
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1037-142 Postsystolic shortening is consistently prevalent in nonviable myocardium in patients with acute myocardial infarction: Comparison with contrast-enhanced magnetic resonance imaging
Authors: Yan Zhang, Anna Chan, Wynnie Lam, Cheuk-Man Yu, Nina So, Gabriel Yip, John Wong, Eugene Wu, John E Sanderson
Journal: Journal of the American College of Cardiology (2004)
Late effects after radiotherapy for breast cancer
Authors: M. Daly, E. J Junor, A. N Harnett
Journal: BMJ (1995)

colleagues also mention that continual feedback may be necessary.We, however, found no significant trend towards a rise in frequency during the second period when this was analysed in smaller time intervals.Unlike us, Stratton and colleagues aspired to a standard defined a priori.The need for frequent feedback may depend on the standard aspired to.
Errors in Management of Patients Dying of Chronic Obstructive Lung Disease
Authors: Charles C. Hunter
Journal: JAMA (1967)

Recent advances in the understanding of chronic obstructive lung disease have led to the general acceptance of several principles of therapy. The primary aim of management is the maintenance of adequate alveolar ventilation. To this end, satisfactory therapy requires the prompt treatment of pulmonary infection and the avoidance of respiratory-depressant drugs. Severe hypoxemia must be alleviated by oxygen, and life threatening hypoventilation corrected by mechanical ventilation. The measures alone often are effective in relieving heart failure secondary to the primary lung disease. The extent to which adherence to the above therapeutic principles contributes to patient survival has not been objectively evaluated. This report analyzes the medical management of a group of patients dying of chronic obstructive disease in the medical wards of two teaching hospitals. The findings provide the basis for revising management of these patients. <h3>Materials and Methods</h3><h3>Selection of Patients.—</h3> The records of all patients dying with diagnosed
Endoscopic treatment for bleeding peptic ulcers: randomised comparison of adrenaline injection and adrenaline injection + Nd:YAG laser photocoagulation.
Authors: L A Loizou, S G Bown
Journal: Gut (1991)

Forty two patients with haemorrhage from peptic ulcers with visible vessels were enrolled in a randomised study comparing endoscopic haemostasis with adrenaline (1:10,000) injections (adrenaline group) and adrenaline injection + neodymium yttrium-aluminium-garnet (Nd:YAG) laser photocoagulation (adrenaline + laser group). The two groups (21 patients each) were well matched for factors affecting outcome. Surgery was performed for continued haemorrhage uncontrolled by endoscopic treatment or rebleeding after two endoscopic treatments. Haemostasis after one treatment was similar in the two groups: adrenaline 16/21 (76%), adrenaline + laser 18/21 (86%). Haemostasis after two treatments was numerically (0.05 less than p less than 0.10) greater in the adrenaline + laser group: 21/21 (100%) v 18/21 (86%). Three patients (14%) in the adrenaline group underwent uneventful emergency surgery. There were no deaths or procedure related complications in either group. Most bleeds from peptic ulcers with visible vessels can be controlled endoscopically without the need for surgery. Both treatments in this study proved highly efficacious in securing haemostasis. Adrenaline injection treatment seems to be the treatment of choice in view of its simplicity, low cost, and availability. Additional Nd:YAG laser treatment may provide a marginal improvement in efficacy, although a much larger trial would be required to prove this.
Health Status of Air Force Veterans Occupationally Exposed to Herbicides in Vietnam
Authors: Joel E. Michalek
Journal: JAMA (1990)

The Air Force Health Study is a 20-year comprehensive assessment of the current health of Air Force veterans of Operation Ranch Hand, the unit responsible for aerial spraying of herbicides in Vietnam. This report compares the noncombat mortality of 1261 Ranch Hand veterans to that of a comparison population of 19,101 other Air Force veterans primarily involved in cargo missions in Southeast Asia but who were not exposed to herbicides. The indirectly standardized all-cause death rate among Ranch Hands is 2.5 deaths per 1000 person-years, the same as that among comparison subjects. After adjustment for age, rank, and occupation, the all-cause standardized mortality ratio was 1.0. In adjusted cause-specific analyses, we found no significant group differences regarding accidental, malignant neoplasm, and circulatory deaths. These data are not supportive of a hypothesis of increased mortality among Ranch Hands.
Autoimmune Thrombocytopenic Purpura in Homosexual Men
Authors: LYNN MORRIS
Journal: Annals of Internal Medicine (1982)

Since November 1980 we have diagnosed 11 cases of severe autoimmune thrombocytopenic purpura in homosexual men; their mean platelet count (± SE) was 16 000 ± 3000/mm3. All patients have been sexually active with multiple partners and exposed to numerous viruses and drugs. During this period, we also have diagnosed 20 cases of classic autoimmune thrombocytopenic purpura in heterosexual persons, with a normal women to men ratio of 3:1. Eight of nine homosexual patients had elevated platelet IgG compared with normal values in eight of 10 homosexual control subjects having normal hemograms (p < 0.01). All responded moderately or completely to steroids. The three patients who had splenectomy had excellent responses. Four of five patients had a decreased helper/suppressor T cell ratio compared to healthy controls (p < 0.001). Circulating immune complexes and total gamma globulin levels were elevated and lymphocytes relatively decreased in homosexual patients compared with homosexual controls (p < 0.05). Thus, some sexually-active homosexual men seem to have an increased incidence of an immune regulation disorder directed against platelets.
Controversy in Obstetrics and Gynecology II
Authors: Robert W. Kistner
Journal: JAMA (1975)

This is the second edition of this compendium of controversial topics in obstetrics and gynecology. It comprises 25 subjects authored by 102 nationally known experts. The format for each controversy is arranged to present three or four alternative points of view followed by terse editorial comment. Ten subjects cover basic obstetrical problems such as management of premature rupture of the fetal membranes, impending labor prior to the 35th week, placenta praevia, fetal monitoring, pain relief, trophoblastic disease, and cesarean hysterectomy. A discussion of medical and surgical methods of conception control is an outstanding contribution since it concentrates on the ever-present controversy of vaginal hysterectomy vs tubal ligation for permanent sterilization. The authors favoring hysterectomy emphasize the fact that abnormal uterine bleeding, pelvic pain, and symptoms of descensus occur in 15% of posttubal ligation patients within three years and that 24% of these patients underwent hysterectomy within five years, 34% within
Left ventricle electro-mechanical asynchrony in patients with acute myocardial infarction correlates with infarct size
Authors: Yan Zhang, A. Chan, W. Lam, N. So, Gabriel W.K. Yip, Mei Wang, P. Ho, D. Tse, C. Chow, Cheuk-Man Yu, John E. Sanderson
Journal: Journal of the American College of Cardiology (2003)
Payment Policy Based on Measurement of Health Care Spending and Outcomes
Authors: Marco D. Huesch
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Apical Hypertrophic Cardiomyopathy: Clinical and Two-Dimensional Echocardiographic Assessment
Authors: ERIC K. LOUIE
Journal: Annals of Internal Medicine (1987)

Of 965 patients with hypertrophic cardiomyopathy evaluated by echocardiography at the National Institutes of Health during a 7-year period, 23 (2%) had a nonobstructive morphologic form, in which wall thickening occurred predominantly in the apical (distal) portion of the left ventricle. The patients ranged in age from 15 to 69 years (mean, 37) and were predominantly male (14 patients) and white (only 1 was of oriental descent). Fifteen patients had significant functional limitation, which was usually caused by exertional dyspnea and fatigue. Several electrocardiographic patterns were identified in the study group, but only 4 of these patients showed "giant" negative T waves. Only 3 patients had a morphologic expression of apical hypertrophy that closely resembled that described in Japanese patients--that is, hypertrophy that was particularly localized and confined to the true left ventricular apex (2 of these patients had giant negative T waves). Hence, hypertrophy located predominantly in the distal left ventricle was uncommon in our primarily North American patient population with hypertrophic cardiomyopathy. Most of our patients showed morphologic and clinical features that were dissimilar to those found previously in Japanese patients with apical hypertrophy.
The IDEAL Cholesterol
Authors: Christopher P. Cannon
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW METHOD OF INOCULATION TO PROVE THE INFECTIVITY OF THE SEMEN IN LATENT SYPHILIS.*
Authors: GEZA KERTSEZ
Journal: British Journal of Dermatology (1931)

Journal Article A NEW METHOD OF INOCULATION TO PROVE THE INFECTIVITY OF THE SEMEN IN LATENT SYPHILIS. Get access GÉZA KERTSÉZ GÉZA KERTSÉZ Ujpest, Hungary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 43, Issue 11, 1 November 1931, Pages 588–592, https://doi.org/10.1111/j.1365-2133.1931.tb09454.x Published: 01 November 1931
Myocardial Infarction Following Transmural Extravasation of Contrast Medium during Left Ventricular Cineangiography
Authors: TSUNG O. CHENG
Journal: Circulation (1963)

An instance of accidental injection of contrast medium into the wall of the left ventricle during retrograde cineangiocardiography is described. The transmural extravasation led to myocardial infarction from which the patient made an uneventful recovery. The mode of occurrence of this complication during selective cineangiocardiography and measures for its prevention are discussed.
F-18 FDG PET Imaging in a Patient With Granulocyte Colony Stimulating Factor Producing Pulmonary Pleomorphic Carcinoma
Authors: Saeko Takahashi, Katsuyuki Kuwabara, Makoto Sawafuji, Satoshi Akiduki, Akitoshi Ishizaka
Journal: Clinical Nuclear Medicine (2008)

We studied the diffusely increased fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) in the vertebrae of a 74-year-old man with granulocyte colony stimulating factor (G-CSF) producing pulmonary pleomorphic carcinoma. The PET findings were due to bone marrow hyperplasia induced by G-CSF and indicate that we should be careful in differentiating these findings from bone metastases and complications with hematological disease. The Tc-99m HMDP bone scan was normal. PET image in another patient with lung cancer after treatment by rhG-CSF resembles that of the described case. PET imaging in a patient with G-CSF producing carcinoma is probably rare.