tbuckley/cabot-search huggingface dataset:
Initial Human Feasibility of Infusion Needle Catheter Ablation for Refractory Ventricular Tachycardia
Authors: John L. Sapp, Christopher Beeckler, Robert Pike, Ratika Parkash, Christopher J. Gray, Katja Zeppenfeld, Vikas Kuriachan, William G. Stevenson
Journal: Circulation (2013)

Ablation of ventricular tachycardia (VT) is sometimes unsuccessful when ablation lesions are of insufficient depth to reach arrhythmogenic substrate. We report the initial experience with the use of a catheter with an extendable/retractable irrigated needle at the tip capable of intramyocardial mapping and ablation.Sequential consenting patients with recurrent VT underwent ablation with the use of a needle-tipped catheter. At target sites, the needle was advanced 7 to 9 mm into the myocardium, permitting pacing and recording. Infusion of saline/iodinated contrast mixture excluded perforation and ensured intramyocardial deployment. Further infusion was delivered before and during temperature-controlled radiofrequency energy delivery through the needle. All 8 patients included (6 male; mean age, 54) with a mean left ventricular ejection fraction of 29% were refractory to multiple antiarrhythmic drugs, and 1 to 4 previous catheter ablation attempts (epicardial in 4) had failed. Patients had 1 to 7 (median, 2) VTs present or inducible; 2 were incessant. Some intramyocardial VT mapping was possible in 7 patients. A mean of 22 (limits, 3-48) needle ablation lesions were applied in 8 patients. All patients had at least 1 VT terminated or rendered noninducible. During a median of 12 months follow-up, 4 patients were free of recurrent VT, and 3 patients were improved, but had new VTs occur at some point during follow-up. Two died of the progression of preexisting heart failure without recurrent VT. Complications included tamponade in 1 patient and heart block in 2 patients.Intramyocardial infusion-needle catheter ablation is feasible and permits control of some VTs that have been refractory to conventional catheter ablation therapy, warranting further study.
Lansley denies that restructuring of the NHS will cost 2-3bn
Authors: Z. Kmietowicz
Journal: BMJ (2010)

The health secretary Andrew Lansley clashed with members of the Health Select Committee on 15 December over the timing of his reforms to the NHS and his inability to put a price tag on how much they will cost.

During the committee’s last evidence gathering hearing into commissioning, Andrew George, Liberal Democrat for St Ives, pointed out that parliament would be taking its decision on the white paper, Liberating the NHS—widely dubbed “The Lansley challenge”—after many of the proposals were already in place.

“It will be a train that has already left the station and is way down the track before parliament can begin expressing a view on it,” he said.

Mr Lansley replied, “The criticism would be fine if this were not an …
Intrahepatic Cholestasis with Fatal Termination Following Norethandrolone Therapy
Authors: Enid F. Gilbert
Journal: JAMA (1963)

THE ANABOLIC STEROIDS which produce nitrogen retention with minimal androgenic activity are receiving wide application in the treatment of cachexia associated with chronic diseases, burns, osteoporosis, and fractures and as an adjunct in prolonged steroid therapy. 1 These agents which include norethandrolone, methyltestosterone, and methandrostenolone may produce alterations in liver function 2-6 and may cause an intrahepatic cholestasis with obstruction and jaundice. This paper presents a case of intrahepatic biliary obstruction due to cholestasis after prolonged administration of norethandrolone.  Report of a Case  A 74-year-old male was treated with norethandrolone in a dosage of 30 mg per day, after a hemiplegia and x-ray evidence of osteoporosis. Therapy was instituted on June 2, 1960. The patient did well until Nov 18, at which time he was noted to be severely icteric. A total serum bilirubin level of 32.4 mg/100 cc with a direct bilirubin of 21.8 mg/100 cc was found at
Akt Phosphorylates Tal1 Oncoprotein and Inhibits Its Repressor Activity
Authors: Alexey Palamarchuk, Alexey Efanov, Vadim Maximov, Rami I. Aqeilan, Carlo M. Croce, Yuri Pekarsky
Journal: Cancer Research (2005)

Abstract The helix-loop-helix transcription factor Tal1 is required for blood cell development and its activation is a frequent event in T-cell acute lymphoblastic leukemia. The Akt (protein kinase B) kinase is a key player in transduction of antiapoptotic and proliferative signals in T cells. Because Tal1 has a putative Akt phosphorylation site at Thr90, we investigated whether Akt regulates Tal1. Our results show that Akt specifically phosphorylates Thr90 of the Tal1 protein within its transactivation domain in vitro and in vivo. Coimmunoprecipitation experiments showed the presence of Tal1 in Akt immune complexes, suggesting that Tal1 and Akt physically interact. We further showed that phosphorylation of Tal1 by Akt causes redistribution of Tal1 within the nucleus. Using luciferase assay, we showed that phosphorylation of Tal1 by Akt decreased repressor activity of Tal1 on EpB42 (P4.2) promoter. Thus, these data indicate that Akt interacts with Tal1 and regulates Tal1 by phosphorylation at Thr90 in a phosphatidylinositol 3-kinase–dependent manner.
THE IMPACT OF CAROTID ARTERY ATHEROSCLEROSIS ON CARDIOVASCULAR OUTCOMES IS DEPENDENT ON PRE-EXISTENT CORONARY ARTERY DISEASE STATUS
Authors: Arie Steinvil, Ben Sadeh, Maayan Konigstein, Ofer Havakuk, Sharon Greenberg, Natan Borenstein, Yaron Arbel, Shmuel Banai, Amir Halkin
Journal: Journal of the American College of Cardiology (2014)
ETHICS OF HUMAN EXPERIMENTATION
Authors: MICHAEL J. BRENNAN
Journal: Annals of Internal Medicine (1966)

Letters and Comments1 December 1966ETHICS OF HUMAN EXPERIMENTATIONMICHAEL J. BRENNAN, M.D.MICHAEL J. BRENNAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1342 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I found your editorial in the August issue of the ANNALS one of great interest. As one whose work has been in the field of medical oncology and as a man committed not only to scientific and medical ideals but to religious ones as well, I have faced the moral issues of investigational medicine for some years. Besides the three basic requirements you propose on p. 372, lower paragraph, I believe there is a fourth. The facilities must be suitable and the work must be published.We need to consider the ordering of diagnostic tests and, certainly,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Michigan Cancer Foundation Detroit, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1966Volume 65, Issue 6Page: 1342-1343 Issue Published: 1 December 1966 PDF DownloadLoading ...
Plasma Interleukin-5 Levels Are Related to Antibodies Binding to Oxidized Low-Density Lipoprotein and to Decreased Subclinical Atherosclerosis
Authors: Maritta Sämpi, Olavi Ukkola, Markku Päivänsalo, Y. Antero Kesäniemi, Christoph J. Binder, Sohvi Hörkkö
Journal: Journal of the American College of Cardiology (2008)
Hematuria Complicating Varicella
Authors: Forris E. Chick
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Dr. A. D. Amar reported a case of hematuria due to varicella lesions of the bladder (<b>196</b>:450, 1966), stating that he was unable to find any reference to this complication in a fairly extensive review of the literature. I was immediately struck by the marked similarity in findings to those in the case I am reporting. At the time I saw this patient, I did not realize that it was such a rare complication of varicella although it was and is the only such case in my experience. <h3>Report of a Case:—</h3> A 7-year-old, well-developed, normal child was seen at her home suffering from varicella of moderate severity involving the skin and the mucous membranes of the mouth. A very few of these lesions appeared slightly hemorrhagic. She ran a moderately severe course with temperatures as high as 102 F for three days, but with full
Herbal Pharmacology and Medical Therapy in the People's Republic of China
Authors: LOUIS LASAGNA
Journal: Annals of Internal Medicine (1975)

A scientific delegation visited the People's Republic of China for the purpose of assessing the current status of herbal pharmacology and medicine there. China is attempting to wed traditional and Western medicine so as to take advantage of the potential contributions of both. This wedding seems possible at the empiric level despite theoretical contradictions. Traditional remedies are widely prescribed, but the actual impact of such medication on disease is difficult to assess, because of the failure of the Chinese up until now to evaluate such remedies by modern clinical trial methodology. All Western drugs are readily available in China, and indeed are manufactured for export as well as for use within the country. The current chinese approach to the patient-doctor relation, and some novel ideas with regard to both medical and surgical therapy pose provocative questions for Western physicians.
The Economic and Academic Status of Women Physicians
Authors: Carlotta Rinke
Journal: JAMA (1981)

THE PROBLEMS that women physicians encounter with professional socialization, peer acceptance, and a career structure that does not accommodate interruptions exact an enormous toll on financial and academic success. Practicing women physicians' incomes have consistently lagged behind men: surveys of 1978 median annual incomes for office-based physicians show that men earn about $65,000 and women earn somewhere from 60% to 69% of that amount.<sup>1,2</sup> Discrepancies arise, however, when averaging incomes for male and female physicians, since the latter aggregate in lower-paying medical specialties. In a 1978 office-based physician population, 53% of practicing women physicians were either psychiatrists, pediatricians, or general-family practitioners. While women cluster in these lower income brackets of medicine, they are poorly represented in the higher income ranks of surgery and its specialties: 24% of male practitioners are surgeons compared with 4% of female surgeons.<sup>1</sup> Thus, the average woman physician not only works in a poorer
National Public Health Leader Caswell Evans Talks of 'Doing Less With Less'
Authors: Thomas B. Cole
Journal: JAMA (1996)

CASWELL A. Evans, Jr, DDS, MPH, had a busy year in 1995. As president of the American Public Health Association (APHA), he presided over the nation's largest organization of public health workers and teachers at a time when federal assistance to state and local public health agencies was being scaled back and managed care organizations were beginning to compete with local agencies for publicly and privately insured patients. Closer to home, where Evans serves as Director of Public Health Programs and Services for Los Angeles County, the public health infrastructure was quaking. California voters approved Proposition 187, a statewide initiative to deny public services to undocumented immigrants, sending a tremor through this community (<i>JAMA</i>. 1995;273:1642-1643). An injunction barred implementation of the new law and required all health care institutions and medical offices to post notices that care would be provided without scrutiny of immigration status, but the issue awaits final
Net digestive absorption and adaptive hyperphagia in adult short bowel patients
Authors: P Crenn
Journal: Gut (2004)

<b>Background and aims:</b> Intestinal adaptation after small bowel resection in humans is debated. We have quantified in adult short bowel (remnant small bowel length &lt;2 m) patients oral intake and net digestive absorption and their evolution over time. <b>Patients and methods:</b> Oral intake and faecal output were studied over three days in 90 patients (39 and 51 without or with parenteral nutrition, respectively) and in 14 patients in early (&lt;6 months) and late (&gt;6 months) periods after digestive continuity. Nitrogen and fat output were measured using chemiluminescence and Van de Kamer techniques, respectively. <b>Results:</b> In the whole group, 81% of patients had hyperphagia (spontaneous oral intake &gt;1.5×resting energy expenditure), independently and negatively related to fat absorption (p&lt;0.01) and body mass index (p&lt;0.001) but not braked by the presence of parenteral nutrition. Protein and fat absorption were related to small bowel length. We observed, in the late in comparison with the early period after digestive continuity: an increase in oral intake (1.6 <i>v</i> 2.3 resting energy expenditure), decrease in stool weight/oral intake ratio, no reduction in per cent fat absorption, and protein absorption improvement associated with a significant increase in the amount of protein absorbed (40 <i>v</i> 64 g/day; p&lt;0.05), both being correlated with remnant small bowel length (p&lt;0.01). <b>Conclusions:</b> This study confirms an adaptive hyperphagia in adult short bowel patients. Over time, hyperphagia and amount of protein absorbed increased, the latter being related to remnant small bowel length, indicating a behavioural adaptation that allows expression of intestinal absorptive adaptation.
Mapping the gene causing X-linked recessive idiopathic hypoparathyroidism to Xq26-Xq27 by linkage studies.
Authors: R V Thakker, K E Davies, M P Whyte, C Wooding, J L O'Riordan
Journal: Journal of Clinical Investigation (1990)

Idiopathic hypoparathyroidism has been reported to occur as an X-linked recessive disorder in two multigeneration kindreds. Affected individuals, who are males, suffer from infantile onset of epilepsy and hypocalcemia, which appears to be due to an isolated congenital defect of parathyroid gland development; females are not affected and are normocalcemic. We have performed linkage studies in these two kindreds (5 affected males, 11 obligate carrier females, and 44 unaffected members) and have used cloned human X chromosome sequences identifying restriction fragment length polymorphisms to localize the mutant gene causing this disorder. Our studies established linkage between the X-linked recessive idiopathic hypoparathyroid gene (HPT) and the DXS98 (4D.8) locus, peak LOD score = 3.82 (theta = 0.05), thereby mapping HPT to the distal long arm of the X chromosome (Xq26-Xq27). Multilocus analysis indicated that HPT is proximal to the DXS98 (4D.8) locus but distal to the F9 (Factor IX) locus, thereby revealing bridging markers for the disease. The results of this study will improve genetic counseling of affected families, and further characterization of this gene locus will open the way for elucidating the factors controlling the development and activity of the parathyroid glands.
Opposite relationships between circulating Dkk-1 and cartilage breakdown in patients with rheumatoid arthritis and knee osteoarthritis: Table 1
Authors: N Voorzanger-Rousselot, N Charni Ben-Tabassi, P Garnero
Journal: Annals of the Rheumatic Diseases (2009)

Recent animal and clinical studies have suggested that Dkk-1, a secreted inhibitor of the canonical Wnt signalling pathway, could play an important role in mediating the alterations of joint tissue turnover associated with rheumatoid arthritis (RA) and osteoarthritis. Diarra et al 1 showed that blockage of Dkk-1 abolished bone erosion in an inflammatory mouse model and that circulating Dkk-1 was increased in patients with active RA. More recently, we reported that increased Dkk-1 was associated with a higher risk of radiological bone erosion in patients with early RA receiving anti-tumour necrosis factor therapy.2 On the other hand, elevated circulating levels of Dkk-1 were reported to be moderately associated with reduced radiological progression of hip osteoarthritis in one study …
338. Microarray Analysis of Genes Regulated during Induction of Osteogenesis by Human Lim Mineralization Protein-3 (LMP-3) in Human Mesenchymal Stem Cells
Authors: Wanda Lattanzi, Camilla Bernardini, Enrico Pola, Andrea Gambotto, Fabrizio Michetti, Paul D. Robbins
Journal: Molecular Therapy (2006)
Respiratory Symptoms in Children and Parental Smoking and Phlegm Production
Authors: J. R. T. Colley
Journal: BMJ (1974)

A study of respiratory symptoms in 2,426 schoolchildren aged 6-14 years was carried out in Aylesbury, Buckinghamshire, in 1971. The prevalence of cough in the children was associated with the parents' smoking habits; prevalence was lowest where both parents were non-smokers, highest where both parents smoked, and lay between these two levels where only one parent smoked. A close association was found between parents' and children's respiratory symptoms that was independent of parents' smoking habits. There was no suggestion that exposure to the cigarette smoke generated when parents smoked had any more than a small effect upon the child's respiratory symptoms. While the sharing of genetic susceptibility between parents and children is a factor, therefore, cross infection, particularly in the families where parents smoke, is an important element in the association.
Case-control study of melanocytic nevi on the buttocks in atypical mole syndrome: Role of solar radiation in the pathogenesis of atypical moles
Authors: Michelle C Abadir, Ashfaq A Marghoob, Johnny Slade, Thomas G Salopek, Sandhya Yadav, Alfred W Kopf
Journal: Journal of the American Academy of Dermatology (1995)

<h2>Abstract</h2> <b>Background:</b> It is not known why melanocytic nevi (MN) become dysmorphic (atypical) in patients with the atypical mole syndrome (AMS). A complex origin for acquired MN has been postulated. Genetic predisposition, solar radiation, and/or the formation of a sun-induced circulating mitogenic factor may contribute to the formation of MN. <b>Objective:</b> This study was undertaken to help elucidate the pathogenesis of atypical MN in patients with AMS. <b>Methods:</b> The number of common and atypical MN was determined for a defined sun-protected area on the buttocks in 150 patients with AMS (cases) and 150 control subjects without AMS. Patients and control subjects were matched for age and sex and were classified into risk groups for the development of malignant melanoma according to the Rigel classification. <b>Results:</b> MN on the buttocks were found in 23% of patients with AMS and 9% of control subjects (<i>p</i> < 0.003). In patients versus control subjects the mean number (1.3 vs 1.2, respectively) and mean diameter (5.7 vs 5.9 mm, respectively) of MN on the buttocks did not differ significantly. The MN in both patients and control subjects were not atypical clinically. The odds ratio for having AMS if MN were present on the buttocks was calculated to be 1.56 (95% confidence interval, 1.25 to 1.95). <b>Conclusion:</b> Although the patients were 2.6 times more likely to have MN on their buttocks than the control subjects, clinically the MN did not differ significantly in number or appearance from those found on the buttocks of control subjects. It is hypothesized that the formation of some atypical MN requires direct solar radiation for their phenotypic expression.
Genetic Factors in Septic Shock
Authors: Anand Kumar
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer
Authors: Hiroyuki Yasuda, Eunyoung Park, Cai-Hong Yun, Natasha J. Sng, Antonio R. Lucena-Araujo, Wee-Lee Yeo, Mark S. Huberman, David W. Cohen, Sohei Nakayama, Kota Ishioka, Norihiro Yamaguchi, Megan Hanna, Geoffrey R. Oxnard, Christopher S. Lathan, Teresa Moran, Lecia V. Sequist, Jamie E. Chaft, Gregory J. Riely, Maria E. Arcila, Ross A. Soo, Matthew Meyerson, Michael J. Eck, Susumu S. Kobayashi, Daniel B. Costa
Journal: Science Translational Medicine (2013)

Crystal structure and detailed analysis of different EGFR mutants explain why some mutations in exon 20 make lung cancers resistant to EGFR inhibitors and others make them more sensitive.
Incomplete Financial Disclosure in a Study of Escitalopram and Problem-Solving Therapy for Prevention of Poststroke Depression
Authors: Robert G. Robinson
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Senator Kennedy's Legacy to U.S. Health and Health Care
Authors: Mona Sarfaty
Journal: New England Journal of Medicine (2009)

Edward M. Kennedy, the long-serving senior senator from Massachusetts who died on August 25, 2009, had a major impact on Americans who deliver or receive health care services and left a vast legacy to our health care system. Kennedy arrived in Congress in 1963 with a dedication to fairness, justice, and equal opportunity and a deep well of personal commitment and energy. He brought his values to bear on the policy areas of his Senate committee assignments, one of which was Health, Education, Labor, and Pensions. The result was an unswerving devotion to universal access to health care, enhanced education . . .