tbuckley/cabot-search huggingface dataset:
Severe Thrombocytopenia and Sarcoidosis
Authors: Arthur R. Knodel
Journal: JAMA (1980)

SEVERE thrombocytopenia is a rare manifestation of sarcoidosis, with only 24 cases and six deaths, including the patient described here, reported. Severe thrombocytopenia in sarcoidosis is most probably secondary to an immune process leading to increased peripheral destruction. Treatment consists of correction of the platelet deficiency and use of corticosteroids. <h3>Report of a Case</h3> A 23-year-old woman was asymptomatic until four days prior to admission, when she had the onset of cough, sore throat, and rhinitis. In the ensuing three days, she noted easy bruisability, epistaxis, and, one day prior to admission, a petechial rash. On the day of admission, she experienced an acute bifrontal headache and became increasingly lethargic. She denied history of chronic cough, exercise intolerance, lymphadenopathy, prior skin rash, fevers, weight change, fatigue, malaise, or bleeding dyscrasias. At the time of admission, her temperature was 37.5 °C; pulse rate, 130 beats per minute; blood pressure, 120/90 mm
Urinary Retention and Episodic Paresthesias
Authors: Nirmish Singla, Alok Sachdeva, Ann Little
Journal: JAMA Surgery (2015)

A36-year-oldmanpresentedwith2weeksof episodicnumbnessandparesthesias inboth feet,with symptom-free intervalsbetweenepisodes.Episodesprogressed in frequencyand duration, occurring several times daily and lasting for hours. His symptoms were prominentafteractivityandreliably triggeredbystrainingwith urinationandterminatedby lyingsupine.Thepatientalso reported a 1-weekhistory of urinary retention requiring intermittent self-catheterization. Neurological examinations both during and between episodes revealed symmetric patellar and Achilles hyperreflexia with bilateral crossed adductor response, but otherwise the resultswere normal. A thoracic spine magnetic resonance imaging scan with fast imaging employing steady-state acquisition (FIESTA) sequences was obtained (Figure). A dynamic computed tomographic myelogram demonstrated a lesion compressing the dorsal spinal cord at the T7 level (Video). Video at jamasurgery.com
A CASE OF INSULIN EDEMA
Authors: Aaron Leifer
Journal: JAMA (1928)

Although I am certain that edema develops frequently in diabetic patients treated with insulin, very few cases have been reported in the literature. I therefore am reporting the following case: I. F., a man, aged 41, a mechanical dentist, seen by me on the afternoon of June 15, 1927, complained of dryness of the mouth and throat, thirst, polyuria, loss of weight, marked weakness and chilliness, all of only one week's duration. The previous medical and surgical history was negative. There was no history of venereal diseases. On physical examination it was observed that the patient was emaciated and pale, well oriented, and not dyspneic. There was a marked odor of acetone to the breath. The head and scalp were normal. The pupils were equal and regular and reacted to light and in accommodation; ocular movements were normal. The nose was normal. Pyorrhea was marked; there were many decayed
Abstract LB-293: Indirubins decrease glioma growth and invasion <i>in vivo:</i> A novel treatment paradigm combining antimigratory and antiangiogenic effects
Authors: Shante’ P. Williams, Michal O. Nowicki, E. Antonio Chiocca, Sean E. Lawler
Journal: Cancer Research (2010)

Abstract The invasive nature of gliomas is a major obstacle to their effective treatment. We demonstrated in a recent report that lithium blocks glioma cell migration and that this involved the inhibition of glycogen synthase kinase-3 (GSK-3). Here we report that treatment of glioma cells with GSK-3 inhibitors of the indirubin family leads to a potent and specific blockade of glioma cell migration. Indirubins inhibited GSK-3 to a greater extent than lithium in glioma cells as assessed by ß-catenin TCF/LEF luciferase reporter assays and were effective at much lower concentrations than other GSK-3 inhibitors so far tested. When examined in intracranial xenograft models in nude mice, 6-bromo-indirubin acetoxime (BIA) led to a significant reduction of invasion of normal, both in terms of diffuse invasion around the tumor, and the number of tumor foci. Interestingly treatment with BIA also led to decreased tumor proliferation and significantly improved survival of tumor-bearing animals. Histological examination of tumors showed a substantial decrease in blood vessel density in tumors. Finally we showed that indirubins block motility of endothelial cells in vitro, and also cause increased production of anti-angiogenic proteins in BIA treated glioma cells. This data suggests that anti-invasive glioma therapy with indirubins, and potentially other GSK-3 inhibitors, not only inhibits invasion of tumor cells, but also blocks angiogenesis providing a novel treatment paradigm for invasive gliomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-293.
Current Practice of Surgery
Authors: George E. Moore
Journal: JAMA (1994)

<i>Current Practice of Surgery</i>is a three-volume, loose-leaf surgical text for $295 with—count them—235 contributors. Semiannual updates are promised, the first included in the purchase price; the volume and cost of subsequent updates are expected to vary but are not available at this writing. The mechanical aspects of such tomes are both good and bad. One can remove a section for review at home or elsewhere without carrying many kilograms of paper. Because of the updatable format, each section begins on its own page 1. The index is cumbersome: entries include roman numerals identifying sections and standard numbers identifying pages for the subjects (analogous to chapters) within the section. The top of each index page lists the volume and the sections in the volume, but it is still awkward to use. Each section has its own title page that lists the "chapters" in that section, but the page numbers are
Abstract P1-02-04: Array based resolution of HER2 amplification status in breast carcinomas displaying apparent chromosome 17 aneusomy
Authors: BP Portier, Z Wang, E Minca, C Lanigan, E Downs-Kelly, RR Tubbs
Journal: Cancer Research (2013)

Abstract Background: Molecular inversion probe (MIP) arrays offer high-quality copy number and genotype data with whole-genome coverage and high resolution of cancer related genes. The MIP array assay is specifically designed for use with Formalin Fixed Paraffin Embedded (FFPE) tissue due to its design which utilizes hybridization of short sequence inversion probes. In this study, we performed MIP array analysis on a cohort of breast carcinomas with putative chromosome 17 aneusomy identified by HER2/CEP17 dual probe FISH. We hypothesized that MIP array performed on cases with chromosome 17 aneusomy would allow HER2 amplification status resolution and provide additional clinically actionable data on genes with predictive and prognostic significance. Design: DNA was extracted from formalin fixed paraffin embedded tissue (Qiagen,Valencia, CA) from invasive breast carcinomas following macrodisection. Breast carcinomas utilized in this study segregated into three groups: 1) Aneusomic 2) Monosomic, and 3) Eusomic cases as determined by FISH utilizing a centromere 17 reference probe (PathVysion; Abbott Molecular). Matched patient normal lymph nodes were performed for a subset of cases from each group. MIP-array data was collected using the Affymetrix OncoScan™ array (Affymetrix, Santa Clara, CA). Analysis of array data was performed using Nexus software v6 (BioDiscovery, Inc., Hawthorne, CA). Result: Array-based detection of HER2 amplification in aneusomic breast carcinomas showed 100% concordance with single probe (HER2) FISH. However, based on genomic profiling, these cases showed great variability in regions of aneusomy along chromosome 17. In our aneusomic cohort, one region of chromosome 17 showed conserved eusomy status. This region was utilized for both array and FISH based ratio to resolve HER2 amplification status in 18 of 22 (82%) of cases. In addition to HER2 status resolution by MIP array, gains and losses in genes involved in modulating therapy were also identified, using this single assay. Conclusion: Use of MIP array-based genotyping as a single reflex assay in breast carcinomas with apparent chromosome 17 aneusomy resulted in HER2 amplification status resolution. In addition, use of this assay in our aneusomic cohort resulted in identification of a highly conserved region of chromosome 17 that is highly resistant to gains or losses in ploidy. The “D17S122” region was confirmed by FISH and use of a HER2/D17S122 ratio, allowed resolution of HER2 amplification status. In addition to HER2 status resolution and copy number data, MIP Array also provided comprehensive genomic coverage for analysis of non EGFR family genes potentially important for prognosis and therapy response prediction. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-02-04.
Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma
Authors: Monica Loi, Serena Marchiò, Pamela Becherini, Daniela Di Paolo, Marco Soster, Flavio Curnis, Chiara Brignole, Gabriella Pagnan, Patrizia Perri, Irene Caffa
Journal: Journal of Controlled Release (2010)
Clinical Features of Diabetes Mellitus in Japan
Authors: Shigeaki Baba, Soichiro Morita
Journal: Diabetes Care (1980)

The first Symposium on Diabetes Mellitus in Asia was held in Kobe, Japan, in 1970 and the second symposium in Kyoto, Japan, in 1975. These two symposia raised many questions. Participants from various countries compared their findings on the frequency of diabetes and its complications. Such comparisons are usually complicated because of the differences in diagnostic criteria used, the age groups compared, and duration of diabetes observed, etc. In spite of these problems, careful analysis and close comparisons may offer important clues as to the pathogenesis of diabetes and the factors related to its complications. Japanese and Caucasian diabetes have some differences resulting from the Japanese diabetic pathophysiologic, ethologic, and ecologic factors. In this paper, diabetes is discussed from an ecologic viewpoint, especially characteristics of the disease and its prognosis in relation to the complications and food habits in Japan.
Nitrous Oxide in Prehospital Care
Authors: R. D. Stewart
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The report by Thal et al (1979;242:2418) concerning the use of nitrous oxide and oxygen mixtures in prehospital care and the comments by Richard N. Hindin, MD (1980;244: 769), raise questions that have been under study for some months at the University of Pittsburgh. The issue of environmental levels of nitrous oxide within ambulance compartments is the subject of a study now being carried out within the mobile intensive care units of the Pittsburgh Emergency Medical Services Department. Preliminary results would indicate that paramedical personnel, while attending patients breathing a self-administered gas mixture, are exposed to higher concentrations of nitrous oxide than have been documented in operating theaters. This exposure is of brief duration, however, and occurs infrequently during an average working day. In initial testing designed to evaluate performance of the ambulance crew, we have been unable to detect any change from control values. The results
Epilepsy and pregnancy.
Authors: M D O'Brien, S Gilmour-White
Journal: BMJ (1993)

ceptualisation and psychoanalytic treatment of psychosis in French psychiatry throughout the 1960s and 1970s.The questionnaire survey showed that British and French psychiatrists also differed over the management of schizophrenia.Although opinion should be distinguished from behaviour, the difference in views probably affects clinical practice.Thus the same patient might be treated very differently in the two countries, even if they happened to have received the same diagnostic label.Conclusion-In psychiatry there is a need for further collaborative projects within the European Community to promote mutual understanding, facilitate communication, and arrive at a consensus for the diagnosis and management of schizophrenia and other psychiatric disorders.In a dialectical Europe different psychiatric traditions should be able to leam from each other but talk in a common language.
Procainamide Hydrochloride and Lupus Erythematosus
Authors: Robert Paine
Journal: JAMA (1965)

Four patients developed a lupus erythematosus (LE)-like syndrome while taking procainamide hydrochloride. All four presented with acute pain in the joints; three with fever; two with pulmonary infiltration; and three with chest pain. Prompt subsidence of symptoms and signs followed cessation of procainamide administration in three patients, while joint symptoms and LE cells persisted until dexamethasone was given to another. Partial subsidence of symptoms and signs, despite continued administration, was observed in one patient. The importance of long-term administration in the genesis of this reaction to procainamide is noted.
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Authors: Ekaterina Rogaeva, Yan Meng, Joseph H Lee, Yongjun Gu, Toshitaka Kawarai, Fanggeng Zou, Taiichi Katayama, Clinton T Baldwin, Rong Cheng, Hiroshi Hasegawa, Fusheng Chen, Nobuto Shibata, Kathryn L Lunetta, Raphaelle Pardossi-Piquard, Christopher Bohm, Yosuke Wakutani, L Adrienne Cupples, Karen T Cuenco, Robert C Green, Lorenzo Pinessi, Innocenzo Rainero, Sandro Sorbi, Amalia Bruni, Ranjan Duara, Robert P Friedland, Rivka Inzelberg, Wolfgang Hampe, Hideaki Bujo, You-Qiang Song, Olav M Andersen, Thomas E Willnow, Neill Graff-Radford, Ronald C Petersen, Dennis Dickson, Sandy D Der, Paul E Fraser, Gerold Schmitt-Ulms, Steven Younkin, Richard Mayeux, Lindsay A Farrer, Peter St George-Hyslop
Journal: Nature Genetics (2007)
Renal Homotransplantation in 24 Patients
Authors: G. Dunea, S. Nakamoto, R. A. Straffon, J. E. Figueroa, A. A. Versaci, M. Shibagaki, W. J. Kolfe
Journal: BMJ (1965)

There are now in the world about 30 patients who have lived longer than one year after homotransplantation from donors other than identical twins (Murray, personal communication, 1964).Several centres in Europe and the United States have made outstanding contributions to the clinical field, and encouraging results have been reported by Hume et al. (1963), Merrill et al. (1963), Shackman et al. (1963), Woodruff et al. (1963), and Starzl et al. (1964a).Results obtained at the present time indicate that useful prolongation of life is possible in from 30 to 50% of patients having terminal renal failure.Between January 1963 and June 1964 27 renal transplanta- tions were performed on 24 patients at the Cleveland Clinic (Table I).Six cases have been reported in detail (Figueroa et al., 1964).As this is a rapidly advancing field we believe it is appropriate to analyse our results and draw preliminary conclusions for future guidance. MethodsPre-operative Treatment.-Al1patients had terminal renal failure ; the nature of the disease is indicated in Table I.Seven patients had been maintained on a chronic haemodialysis programme (Brandon et al., 1962) from 6 to 18 months and had received from 72 to 138 haemodialyses.Since December 1963 dialysis was used mainly to prepare patients for trans- plantation.Bilateral nephrectomy was performed about two weeks before living-donor-kidney transplantations and about 10 to 14 days after cadaver-kidney transplantations.Splenectomy was performed in eight patients and thymectomy in nine.Choice of Donors.-Closeblood relatives served as living donors and an unrelated living donor (brother-in-law) was used only once.A general medical examination, tests of renal function, and renal arteriography were carried out on all living donors.Donors with young children or having family respon- sibilities were avoided.Cadaver donors with a history of renal disease or hypertension were not used. Operative DetailsCadaver donors were heparinized after death, an infusion of low-molecular-weight dextran' was given, and closed chest cardiac massage and artificial respiration were performed until
839. Long-Term Knockdown of Phospholamban in Cultured Neonatal Rat Cardiomyocytes by a Viral Vector Expressing PLB-shRNAs
Authors: Lennart Suckau, Jens Kurreck, Roland Vetter, Stefan Weger, Jos Lamers, Wolfgang Poller, Henry Fechner
Journal: Molecular Therapy (2006)

Top of pageAbstract
Impaired function of the phospholamban (PLB)-regulated sarcoplasmic reticulum (SR) Ca2+ pump (SERCA2a) is crucial for contractile dysfunction in heart failure. Recently, downregulation of PLB by a synthetic small interfering (si) RNA was found to be linked to up-regulation of the SR Ca2+ pump activity of neonatal rat cardiomyocytes. However, the application of latter approach under in vivo conditions may be limited due to the low transfer efficacy and the poor stability of siRNA. Therefore, we constructed an adenoviral vector expressing a PLB-shRNA from a murine polymerase III U6 promoter for knocking down PLB expression. The efficacy of this vector to suppress PLB expression and to modulate SERCA2a- catalysed reticular Ca2+ transport was examined. Transduction of cultured neonatal rat cardiomyocytes with the vector resulted in a marked and sustained decrease of PLB gene expression. At day 2 after transduction, the PLB-mRNA signal was suppressed by more than 95% and stayed at this low level until the end of the experiment at day 13. At the protein level, maximum PLB downregulation was achieved at day 7 (-90% vs. control). SERCA2a and Na/Ca exchanger expression were not altered. PLB knockdown was associated with a marked increase of the oxalate-supported Ca2+ uptake rate that was measured in cell homogenates at 0.34 |[mu]|M free Ca2+. Thus, the use of adenoviral PLB-shRNA is a powerful approach for a long-term increase of the SERCA2a-catalysed Ca2+ transport into the SR of cultured neonatal rat cardiomyocytes.
Persistent expression of CXCR5 on plasmablasts in IgG4-related disease
Authors: Syuichi Koarada, Satoko Tashiro, Yukiko Tokuda, Yukihide Ono, Yuri Sadanaga, Rie Suematsu, Nobuyuki Ono, Akihide Ohta, Yoshifumi Tada
Journal: Annals of the Rheumatic Diseases (2015)

Persistent expression of CXCR5 on plasmablasts in IgG4-related diseaseWe read with interest the papers by Fox and Fox, 1 and Wallace et al 2 on IgG4 levels and plasmablasts as a marker for IgG4-related disease (IgG4-RD).We strongly approve their results and have reported plasmablasts lacking RP105 (CD180) in IgG4-RD in your journal. 3Recently, we have found an important and additional result about plasmablasts in IgG4-RD.RP105-negative B cells are assigned as five subsets of activated late B cells (subset 1), early or pre-plasmablasts (subset 2), plasmablasts (subset 3), early plasma cells (subset 4) and plasma cells (subset 5). 4 However, precise phenotype of RP105-negative B cells in IgG4-RD was hitherto unknown. 5To clarify the phenotype of RP105-negative B cells, multicolour analysis (more than 200 antigens on B cells) has been performed using a flow cytometry in IgG4-RD (n=10), patients with systemic lupus erythematosus (SLE) (n=11) and normal subjects (n=5).Increased RP105-negative plasmablasts are found in patients with both IgG4-RD and SLE.Interestingly, while early plasma
Outbreaks Following Wild Poliovirus Importations—Europe, Africa, and Asia, January 2009–September 2010
Authors: Norman M Kaplan
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systematic Review on the Efficacy of Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis From Colorectal Carcinoma
Authors: Tristan D. Yan, Deborah Black, Renaldo Savady, Paul H. Sugarbaker
Journal: Journal of Clinical Oncology (2006)

The efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for patients with peritoneal carcinomatosis from colorectal carcinoma remains to be established.A systematic review of relevant studies before March 2006 was performed. Two reviewers independently appraised each study using a predetermined protocol. The quality of studies was assessed. Clinical effectiveness was synthesized through a narrative review with full tabulation of results of all included studies.Two randomized controlled trials, one comparative study, one multi-institutional registry study, and 10 most recent case-series studies were evaluated. The level of evidence was low in 13 of the 14 eligible studies. The median survival varied from 13 to 29 months, and 5-year survival rates ranged from 11% to 19%. Patients who received complete cytoreduction benefited most, with median survival varying from 28 to 60 months and 5-year survival ranging from 22% to 49%. The overall morbidity rate varied from 23% to 44%, and the mortality rate ranged from 0% to 12%.The current evidence suggests that cytoreductive surgery combined with perioperative intraperitoneal chemotherapy is associated with an improved survival, as compared with systemic chemotherapy for peritoneal carcinomatosis from colorectal carcinoma.
METHOD FOR THE ISOLATION AND RAPID IDENTIFICATION OF DYSENTERIC BACILLI
Authors: I. J. KLIGLER
Journal: JAMA (1918)

Bacillary dysentery is endemic in the United States, and localized epidemics occur from time to time. Our Army and Navy particularly stand in danger from this disease. Of late, confusion has arisen regarding its etiology, as a result of the failure of the isolation of<i>B. dysenteriae</i>from the stools of patients. These fac tors have led us to devise an improved method of isolation and rapid identification of these organisms. The failure on the part of some workers to isolate the true dysentery bacilli from cases of clinical dysentery is attributable largely to two factors: (1) the improper selection of stool specimens for cultures, and (2) the use of unfavorable culture mediums. <h3>1. Selection of Stool Specimens for Plating.</h3> —Too much emphasis cannot be laid on the importance of choosing a satisfactory sample of stool. If possible, one containing blood and mucus with little or no fecal matter should
Histology-Related Associations of ERCC1, RRM1, and TS Biomarkers in Patients with Non–Small-Cell Lung Cancer: Implications for Therapy
Authors: Martin K.H. Maus, Philip C. Mack, Stephanie H. Astrow, Craig L. Stephens, Gary D. Zeger, Peter P. Grimminger, Jack H. Hsiang, Eric Huang, Tianhong Li, Primo N. Lara, Kathleen D. Danenberg, David R. Gandara
Journal: Journal of Thoracic Oncology (2013)