Tamoxifen and Metastatic Breast Cancer
Authors: Kathleen I. Pritchard, J. William Meakin, Robert E. Myers, Donald J. A. Sutherland, Betty G. Mobbs
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 November 1978Tamoxifen and Metastatic Breast CancerKATHLEEN I. PRITCHARD, M.D., F.R.C.P.(C), J. WILLIAM MEAKIN, M.D., F.R.C.P.(C), ROBERT E. MYERS, M.D., F.R.C.P.(C), DONALD J. A. SUTHERLAND, M.D., F.R.C.P.(C), BETTY G. MOBBS, PH.D.KATHLEEN I. PRITCHARD, M.D., F.R.C.P.(C)Search for more papers by this author, J. WILLIAM MEAKIN, M.D., F.R.C.P.(C)Search for more papers by this author, ROBERT E. MYERS, M.D., F.R.C.P.(C)Search for more papers by this author, DONALD J. A. SUTHERLAND, M.D., F.R.C.P.(C)Search for more papers by this author, BETTY G. MOBBS, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-721_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent article by Legha, Davis, and Muggia (Ann Intern Med 88:69-77, 1978) documents the effectiveness of tamoxifen in postmenopausal women with metastatic breast cancer but refers to only one report of its use in premenopausal women (1). Other reports have documented its use only occasionally in premenopausal women (2-5). We report here the preliminary results of a phase II trial of tamoxifen in premenopausal women with metastatic breast cancer.Thirty premenopausal patients with measurable metastatic breast cancer who had received no prior hormonal manipulation were given tamoxifen, 40 mg daily, in two divided doses. Of the...References1. MORGANSCHEINHOTHMCDONALDPOSEYBEAZLEYTRENCH LPDJLRL: Therapeutic use of tamoxifen in advanced breast cancer: a correlation with biochemical parameters (abstract). Proc Am Assoc Cancer Res 17:126, 1976 Google Scholar2. HEUSON J: Current overview of EORTC clinical trials with tamoxifen. Cancer Treat Rep 60:1463-1466, 1976 MedlineGoogle Scholar3. MANNITRUVILLOMARSHALLPEARSON AJJO: Antiestrogen induced remissions in stage IV breast cancer. Cancer Treat Rep 60:1445-1450, 1976 MedlineGoogle Scholar4. LERNERBANKISRAELLEUNG HPLB: Phase II study of tamoxifen: report of 74 patients with stage IV breast cancer. Cancer Treat Rep 60:1431-1435, 1976 MedlineGoogle Scholar5. TORMEYSIMONLIPPMANBULLMYERS DRMJC: Evaluation of tamoxifen dose in advanced breast cancer: a progress report. Cancer Treat Rep 60:1451-1459, 1976 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KATHLEEN I. PRITCHARD, M.D., F.R.C.P.(C); J. WILLIAM MEAKIN, M.D., F.R.C.P.(C); ROBERT E. MYERS, M.D., F.R.C.P.(C); DONALD J. A. SUTHERLAND, M.D., F.R.C.P.(C); BETTY G. MOBBS, PH.D.Affiliations: University of Toronto Toronto, ON M5S 1A8 Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCytological Evaluation of the Effect of Tamoxifen In Premenopausal and Post-Menopausal Women With Primary Breast Cancer By Analysis of the Karyopyknotic Indices of Vaginal SmearsOn the role of additive hormone monotherapy with tamoxifen, medroxyprogesterone acetate and aminoglutethimide, in advanced breast cancerChemohormonal therapy and endocrine function in breast cancer patientsTreatment of advanced breast cancer with megestrol acetate after therapy with tamoxifenLactation from Tamoxifen in Breast CancerGREGORY R. FAVIS, M.D., JANE B. ALAVI, M.D., JOHN H. GLICK, M.D. 1 November 1978Volume 89, Issue 5_Part_1Page: 721-722KeywordsBreast cancerPhase 2 trials ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...