tbuckley/cabot-search huggingface dataset:
Induction of B cell responses in the stomach of Helicobacter pylori- infected subjects after oral cholera vaccination.
Authors: A Mattsson, H Lönroth, M Quiding-Järbrink, A M Svennerholm
Journal: Journal of Clinical Investigation (1998)

We have evaluated the possibility of inducing antibody responses locally in the human stomach as a prerequisite for the development of a vaccine against Helicobacter pylori. Both H. pylori-infected and noninfected subjects were immunized with an oral B subunit whole cell (BS-WC) cholera vaccine, and total and vaccine-specific antibody-secreting cells (ASC) were determined by the enzyme-linked immunospot (ELISPOT) technique in cells isolated from the antrum and duodenum, respectively, before and after vaccination. Most of the subjects responded to the vaccination with high frequencies of vaccine-specific ASCs in the duodenum as well as high-serum antibody titers, and no significant differences were seen in the responses between H. pylori- infected and noninfected subjects. When studying the gastric mucosa, on the other hand, there were dramatic differences between the H. pylori-infected and the noninfected subjects. Thus, whereas none of the noninfected subjects responded to the immunization in antrum, most of the H. pylori-infected subjects had high frequencies of vaccine-specific ASCs in this location after vaccination. Furthermore, the H. pylori-infected subjects had strikingly higher (as a mean 80-fold) frequencies of total IgA-secreting cells in antrum than the noninfected subjects, whereas the frequencies of total IgA-secreting cells in the duodenum were comparable between the groups. In conclusion, these results demonstrate the possibility of inducing antibody responses locally in the gastric mucosa of H. pylori-infected individuals, a finding with obvious implications for the future development of a therapeutic vaccine against H. pylori.
Myocardial Actions of Angiotensin
Authors: JAN KOCH-WESER
Journal: Circulation Research (1964)

Synthetic angiotensin a has pronounced inotropic effects on isometrically contracting, isolated papillary muscles of kittens. The response increases with drug concentration over the range from 10 -10 M to 10 -5 M. The mean maximum increase in tension development is 120%. Contractility is raised by angiotensin through an increase in the degree of activation of the contractile elements with no significant change in the duration of their active state. Low concentrations of angiotensin have a greater inotropic action than equimolar concentrations of l -norepinephrine; but the maximum inotropic effect obtainable with l -norepinephrine is almost twice that of angiotensin. The inotropic effects of angiotensin on cat atrial muscle are slight, and the drug is inactive on frog ventricular myocardium. It has no effect on the resting length-tension relationship of mammalian atrial or ventricular muscle. The frequency of impulse formation in the SA node is not significantly changed by concentrations of angiotensin up to 10 -5 M. In marked contrast to levarterenol, angiotensin does not cause ectopic impulse formation in atrial or ventricular muscle. It is suggested that the positive inotropic effect of angiotensin on ventricular myocardium is of importance for the pressor action of the drug in the intact circulation. The increase in myocardial contractility tends to minimize or prevent decreases in cardiac output in the face of increased resistance to cardiac ejection and thus supports the elevation of arterial pressure.
Changing Attitudes Toward Therapeutic Abortion
Authors: Kenneth R. Niswander
Journal: JAMA (1966)

Few topics are as controversial as that of therapeutic abortion. Not long ago the news media reported fully the predicament of the pregnant women who had taken thalidomide. The necessity for one woman to go to Sweden to obtain an abortion previously denied her in this country dramatized the plight of these women and ignited further discussion. Many people were ready to reconsider the probability that there are conditions which justify the termination of a pregnancy, in which case, the means to such termination should be made legally available. The question remains so controversial, however, that even when the policy of a particular hospital is well established, some staff members diligently work to tighten the requirements for abortion, whereas others strive to liberalize hospital policy. Evidence is accumulating, nevertheless, that our attitudes toward abortion are changing. Ashley Montagu<sup>1</sup>has pointed out the manner in which our society may abandon
Failures of process at the GMC
Authors: R. Colman
Journal: BMJ (2000)

The General Medical Council is the organisation which doctors as well as the public are asked to trust to regulate the medical profession. While the members of the public may have doubts about the ability of the profession to regulate itself in their best interests, there are increasing doubts, after the case of the Bristol paediatric surgeons, about the ability of the GMC to be fair in the treatment of individual doctors.

> PCC procedures need to be more robust and less influenced by individuals 

I was privileged to be an elected member of the GMC for five years from 1994 to 1999. I sat on the professional conduct committee (PCC) for two years. For nine out of the 10 weeks I felt comfortable, but one week left me very disturbed. What I considered was my duty to speak led me into conflict with the GMC, which took out an injunction to prevent me from expressing my concerns (25 March, p 822).

It is the first hearing of a case before the PCC which is …
Doctors accused of discriminating against Down's syndrome patients
Authors: Debashis Singh
Journal: BMJ (2004)

The Down's Syndrome Association this week accused doctors of discriminating against people with Down's syndrome who have developed dementia by either delaying or not offering access to the full range of social and medical treatments available to them.

The association, which is the United Kingdom's main charity that champions the rights of people with the syndrome, states that lack of understanding means that many doctors overlook the possibility of dementia in middle aged people with the syndrome. Instead, doctors tend to attribute the distressing symptoms of dementia to learning difficulties that all people with Down's syndrome have to some …
Adenosine: an importance beyond ATP.
Authors: A H Watt, P A Routledge
Journal: BMJ (1986)

chronic back problems'3; nor does it reduce long term complications or prevent recurrences.Manipulation may thus speed recovery of a few of those with acute backache, which is valuable as it will get some people back to work more quickly.Alternative approaches will be needed to prevent recurrences and help those with chronic backache.
Multiple Cutaneous Swellings Associated With Sudden Collapse
Authors: Sarah J. Felton, Janice E. Ferguson
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of Murine Hepatocyte Death by Membrane-Bound CD95 (Fas/APO-1)-Ligand: Characterization of an In Vitro System
Authors: Stephan F. Schlosser, Francesco Azzaroli, Tao Dao, Ravi Hingorani, Nicholas I. Crispe, James L. Boyer
Journal: Hepatology (2000)

Hepatocytes constitutively express CD95 (also called Fas/APO-1) and are therefore potential targets for CD95-ligand (CD95L)-mediated injury. To study this mechanism of cell death in hepatocytes we developed an in vitro model of liver cell apoptosis using membrane-bound CD95L as the inducing agent. Primary mouse hepatocytes were cocultured with NIH 3T3 fibroblasts, stably transfected with mouse CD95L (F CD95L+ ). Fibroblasts stably transfected with vector only (F CD95L− ) served as controls. Hepatocytes from mice expressing low levels of CD95 (Fas lpr mice) served as controls for effects unrelated to CD95. Morphologic and biochemical studies indicate that CD95 is expressed in cultured mouse hepatocytes. Membrane-bound CD95 from transfected fibroblasts destroyed all cocultured hepatocytes within 24 hours in the absence of protein synthesis inhibitors. Characteristic features of apoptosis were observed in dying hepatocytes and occurred in the following sequence: formation of cytoplasmic blebs and nuclear condensation after 3 hours; nuclear fragmentation and DNA strand breaks after 4 hours. These changes were observed only when normal hepatocytes were cocultured with F CD95L+ and were not observed with F CD95L− or in hepatocytes from Fas lpr mice. Anti-CD95 antibody (Jo2) evoked similar changes in hepatocytes, although to a much lesser extent. We conclude that coculture of mouse hepatocytes with F CD95L+ is a useful in vitro model for CD95-mediated apoptosis induced by CD95L. The high incidence of apoptosis caused by membrane-bound CD95L differs from the much smaller effects induced by the Jo2 antibody. In view of the high sensitivity of hepatocytes towards CD95L we speculate that CD95L-induced liver damage in vivo may be minimized by restricting exposure of hepatocytes to CD95L.
Novel Methods of Management of Trapped Dormia Baskets in the Pancreatic and Biliary Ducts
Authors: M. Mutignani, A. Gabbrielli, N. Murali, V. Perri, G. Costamagna
Journal: Endoscopy (1997)

See also: Dormia Baskets Impacted in the Bile Duct: Release by Extracorporeal Shock-Wave LithotripsyEndoscopy 1995; 27(05): 384-387DOI: 10.1055/s-2007-1005718
Targeted Delivery of Oligodeoxynucleotides to Mouse Lung Endothelial Cells in Vitro and in Vivo
Authors: Annette Wilson, Wen Zhou, Hunter C. Champion, Sean Alber, Zhi-Lue Tang, Steven Kennel, Simon Watkins, Leaf Huang, Bruce Pitt, Song Li
Journal: Molecular Therapy (2005)

Pulmonary endothelium plays an important role in the maintenance of normal pulmonary physiology and its dysfunction is involved in a number of pulmonary diseases. Correction of endothelial dysfunction via antisense oligodeoxynucleotides (ODN) is dependent on the development of a delivery vehicle that can efficiently deliver the ODN to pulmonary endothelium with minimal toxicity. To this end, we have developed a novel lipidic vector that is highly efficient in targeted delivery of ODN to pulmonary endothelium. This is based on a method that utilizes an ionizable aminolipid (1,2-dioleoyl-3-dimethylammonium propane) and an ethanol-containing buffer system for encapsulating large quantities of polyanionic ODN in lipid vesicles. An endothelium-specific antibody (273-34A) is incorporated into the lipid vesicles via a distearoylphosphatidylethanolamine-poly(ethylene glycol) spacer. The 273-34A antibody efficiently mediated delivery of ODN to mouse lung endothelial cells in vitro and in vivo. Furthermore, systemic administration of this formulation is associated with minimal hematological toxicities and induces little acute change in systemic and pulmonary hemodynamics. These results provide a basis for lipid-mediated delivery of ODN for the treatment of pulmonary diseases. They also suggest the utility of this approach as a research tool to characterize the function of genes in the pulmonary endothelium.
Case 56-1963
Authors: William P. Rogers, Benjamin Castleman
Journal: New England Journal of Medicine (1963)

Presentation of CaseA thirty-year-old truck driver was admitted to the hospital because of pain in the chest.The patient had been well until eight months previously, when he experienced an attack of dyspnea while driving his truck. He was told that an electrocardiogram taken at that time was abnormal and that a subsequent radiologic examination revealed a normal heart and a "growth on a bone in the chest." Two days before admission right-sided pleuritic pain suddenly developed, without cough, sputum, hemoptysis or dyspnea. He smoked 1 or 2 packs of cigarettes daily and occasionally drank beer.Physical examination disclosed . . .
1028 RENAL SAFETY AND ANTIVIRAL EFFICACY OF TENOFOVIR DISOPROXIL FUMARATE (TDF) MONOTHERAPY IN NUCLEOS(T)IDE ANALOGUE REFRACTORY PATIENTS WITH HEPATITIS B VIRUS (HBV) MONO-INFECTION
Authors: F. van Bömmel, R.A. De Man, P. Ferenci, J.G. Reijnders, J.-P. Bronowicki, H. Wedemeyer, A. Brodzinski, B. Fülöp, K. Deterding, A. Erhardt, D. Hüppe, M. Bourlière, C. Sarrazin, J. Trojan, P.B. Buggisch, J. Petersen, U. Spengler, A. Pariente, M. Schuchmann, H. Wasmuth, K. Stein, K. Rutter, H.-H. Feucht, B. Wiedenmann, T. Berg
Journal: Journal of Hepatology (2010)
The Relation Between Pressure and Flow in the Pulmonary Circulation in Normal Subjects and in Patients with Chronic Bronchitis and Mitral Stenosis
Authors: P. Harris, N. Segel, J. M. Bishop
Journal: Cardiovascular Research (1968)

Journal Article The Relation Between Pressure and Flow in the Pulmonary Circulation in Normal Subjects and in Patients with Chronic Bronchitis and Mitral Stenosis Get access P. Harris, P. Harris * From the Department of Medicine, Queen Elizabeth Hospital, Birmingham * Present address: Institute of Cardiology, 35 Wimpole Street, London, W.1. Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Segel, N. Segel From the Department of Medicine, Queen Elizabeth Hospital, Birmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar J. M. Bishop J. M. Bishop From the Department of Medicine, Queen Elizabeth Hospital, Birmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 2, Issue 1, January 1968, Pages 73–83, https://doi.org/10.1093/cvr/2.1.73 Published: 01 January 1968 Article history Received: 20 March 1967 Published: 01 January 1968
Hair Loss during Carbimazole Therapy
Authors: F. I. Lee, N. H. Dyer
Journal: BMJ (1967)

allergies demonstrated by skin tests and was unable to show eczema, though urticaria occurred in some.Freedman' could not cause exacerbation in eczema subjects given milk, though skin tests were positive.Brown and Holman4 substitute goats' milk for cows' milk in the diet of nine children with infantile eczema without benefit.Many reports of milk allergy describe symptoms in the first few weeks of life when eczema rarely occurs.The general impres- sion given by the speakers at the conference on infantile eczema held in New York in 1963' was that local treatment was most important and that though skin tests and food allergy played some part in the urticarial reaction they bore little relationship to atopic eczema.There is therefore a considerable weight of opinion supported by a large amount of research against the importance of dietetic treatment of infantile eczema.Until it can be shown by a carefully controlled trial that the natural history of eczema can be altered by elimination diets I will remain a nondieter.Many babies with eczema do improve rapidly with a variety of treatment, and par- ticularly if the parents' anxiety is diminished by belief in their physician's advice.We all have our pet ways of managing eczema, but success may not be based on what we do but how we do it.I am sure Dr. Tate's observa- tion that his patient's do recover on diet is correct, but he underestimates the effect of his personality while overestimating the effect of the food allerdy.-Iam, etc.,
Stimuli‐Sensitive Synthetic Polypeptide‐Based Materials for Drug and Gene Delivery
Authors: Chaoliang He, Xiuli Zhuang, Zhaohui Tang, Huayu Tian, Xuesi Chen
Journal: Advanced Healthcare Materials (2011)

Abstract Stimuli‐sensitive synthetic polypeptides are unique biodegradable and biocompatible synthetic polymers with structures mimicking natural proteins. These polymers exhibit reversible secondary conformation transitions and/or hydrophilic–hydrophobic transitions in response to changes in environmental conditions such as pH and temperature. The stimuli‐triggered conformation and/or phase transitions lead to unique self‐assembly behaviors, making these materials interesting for controlled drug and gene delivery applications. Therefore, stimuli‐sensitive synthetic polypeptide‐based materials have been extensively investigatid in recent years. Various polypeptide‐based materials, including micelles, vesicles, nanogels, and hydrogels, have been developed and tested for drug‐ and gene‐delivery applications. In addition, the presence of reactive side groups in some polypeptides facilitates the incorporation of various functional moieties to the polypeptides. This Review focuses on recent advances in stimuli‐sensitive polypeptide‐based materials that have been designed and evaluated for drug and gene delivery applications. In addition, recent developments in the preparation of stimuli‐sensitive functionalized polypeptides are discussed.
The Preteen's First Book About Love, Sex, and AIDS
Authors: Lamar E. Evans
Journal: JAMA (1995)

<i>The Preteen's First Book About Love, Sex, and AIDS</i>is a very informative book because it answers questions that teens may have, such as what it means to be sexual, is sex the same as love, how to be safe from AIDS, and a lot more. I enjoyed this book because it deals with important issues in the world today. AIDS, for instance, is covered thoroughly by the author, who explains in simple terms how you can get it, how to protect yourself, and how the virus is spread. I also enjoyed the book because the author doesn't tell only about the bad things that can happen if you have sex nor does she seem to condemn teens who are sexually active, but she does make sure that a sexually active teen who reads this book will be aware of what could happen. I would recommend this book not only
PRELIMINARY REPORT OF THE TREATMENT OF IDIOPATHIC EPILEPSY BY APPENDICOSTOMY FOR COLONIC IRRIGATION.
Authors: ERNEST LAPLACE
Journal: JAMA (1906)

Epilepsy is but a symptom revealing some irritation of the general nervous system. It has been aptly divided for purposes of classification into traumatic and idiopathic. In traumatic epilepsy, the cause is evident. Pressure from bone, foreign body, or blood clot is the source which so irritates the brain as to interfere materially with the normal distribution of nerve force through the body. Certain chemical substances have a distinct affinity for the cortical cells of the brain and cord and, as a result, excite them. Among the alkaloids, strychnin is prominent. Among toxins resulting from infection, the poison of tetanus and hydrophobia afford us similar examples. These toxins generated in the body under the influence of the developing pathogenic organism finally accumulate to such an extent as to produce a violent action on the cerebrospinal system, followed by contractions of the muscular system characteristic of these diseases. Very similar is
Abstract 2802: Altered expression and the missense polymorphism of the human base excision repair gene NTH1 in gastric cancer
Authors: Masanori Goto, Kazuya Shinmura, Hiroyuki Konno, Haruhiko Sugimura
Journal: Cancer Research (2010)

Abstract Reactive oxygen species generated in living cells during normal cellular metabolism and in response to exogenous inducers cause the formation of oxidatively damaged bases in DNA. These oxidized base lesions are primarily removed by the base excision repair (BER) pathway. A BER enzyme, NTH1, has activity that is capable of removing oxidized pyrimidines, such as thymine glycol, from DNA. To clarify whether the NTH1 gene is involved in gastric carcinogenesis, we first examined the NTH1 expression level in eight gastric cancer cell lines, and the results showed that NTH1 expression was downregulated in all of them, including cell line AGS. Next, a comparison of excisional repair activity against thymine glycol by empty-vector-transfected AGS clones and FLAG-NTH1-expressing AGS clones showed that a low NTH1 expression level led to low capacity to repair the damaged base in the gastric epithelial cells. Reduced mRNA expression of NTH1 was also detected in 36% (18/50) of primary gastric cancers. Moreover, immunohistochemical analysis revealed that NTH1 was predominantly localized in the cytoplasm in 24% (12/50) of the primary gastric cancers in contrast to the nuclear localization in non-cancerous tissue, suggesting impaired excisional repair ability for nuclear DNA. Next, we found two novel genetic polymorphisms, i.e., c. −163C&amp;gt;G and c. −241_-221del, in the NTH1 promoter region, and a luciferase assay showed that both were associated with reduced promoter activity. However, there were no associations between the polymorphisms and risk of gastric cancer in a gastric cancer case-control study. Next, all the coding exons of the NTH1 gene and their boundary regions in DNAs of 23 Japanese patients with gastric cancer was searched for genetic polymorphisms by direct sequencing. A novel variant, c. −31A&amp;gt;G, and a single nucleotide polymorphism, c.98G&amp;gt;A (Arg33Lys, rs2302172) were detected at an allele frequency of 2.2%, and 4.3%, respectively. However, the c. −31A&amp;gt;G polymorphism did not affect reduction of promoter activity. We are going to reveal functional characterization of c.98G&amp;gt;A and to examine excisional repair activity against new substrates, such as oligonucleotide containing etheno adducts. Our data suggested that downregulation of NTH1 expression, abnormal localization of NTH1 and the missense polymorphism may be involved in the pathogenesis of a subset of gastric cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2802.
TCT-82 Thoracoscopically Assisted Transcatheter Ventricular Restoration Reverses Left Ventricle Remodeling in the Chronic Anteroseptal Aneurysmal Ovine Model
Authors: Yanping Cheng, Lon S. Annest, Kevin Van Bladel, Ryan A. Brown, Andrew Wechsler, Masahiko Shibuya, Gerard B. Conditt, Athanasios Peppas, Greg L. Kaluza, Juan Granada, Geng-Hua Yi
Journal: Journal of the American College of Cardiology (2014)
TCT-691 Gallium SPECT/CT and PET/CT Fusion Imaging for the Assessment of Prosthetic Valve Endocarditis Prior to Percutaneous Paravalvular Leak Closure
Authors: Chad Kliger, Ayushi Singh, Leandro C. Maranan, Robert Kumar, Vladimir Jelnin, Stephen Scharf, Itzhak Kronzon, Anja Summers, Carlos E. Ruiz
Journal: Journal of the American College of Cardiology (2013)
Corrigendum to ‘Analysing recurrent hospitalizations in heart failure: a review of statistical methodology, with application to CHARM-Preserved’ [<i>Eur J Heart Fail</i>2014;16:33-40]
Authors: Jennifer K. Rogers, Stuart J. Pocock, John J.V. McMurray, Christopher B. Granger, Eric L. Michelson, Jan Östergren, Marc A. Pfeffer, Scott D. Solomon, Karl Swedberg, Salim Yusuf
Journal: European Journal of Heart Failure (2014)
The Decameron of poor research
Authors: Vance W Berger, John P A Ioannidis
Journal: BMJ (2004)

<i>Most gracious readers, two boring researchers present a series of pitiful tales—covert and overt fraud, petty misdeeds, and misconceptions by honest and not so honest researchers, professors, industry sponsors, bureaucrats, and other legendary adventurers of modern science</i>