Amphotericin-B-Induced Thrombocytopenia
Authors: CLARA S. P. CHAN
Journal: Annals of Internal Medicine (1982)

Brief Reports1 March 1982Amphotericin-B-Induced ThrombocytopeniaCLARA S. P. CHAN, M.D., CARMELITA U. TUAZON, M.D., LAWRENCE S. LESSIN, M.D.CLARA S. P. CHAN, M.D.Search for more papers by this author, CARMELITA U. TUAZON, M.D.Search for more papers by this author, LAWRENCE S. LESSIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-332 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite its toxicity amphotericin B is the drug of choice for treatment of most fungal infections. The known adverse effects, including anemia, hypokalemia, hypomagnesemia, and renal insufficiency, are generally reversible when therapy is interrupted (1). Thrombocytopenia has been noted in patients receiving amphotericin B (2). However, because thrombocytopenia occurred with concomitant chemotherapy, the presence of sepsis, or an underlying malignancy such as leukemia in relapse, a definite cause-and-effect relation between amphotericin B and thrombocytopenia could not be established.We describe a patient with acute leukemia in complete hematologic remission who developed reversible thrombocytopenia with two courses of amphotericin B for...References1. MILLERBATES RJ. Amphotericin toxicity. A follow-up report of 53 patients. Ann Intern Med. 1969;71:1089-95. LinkGoogle Scholar2. SWANSONCOOK MR. Drugs, Chemicals and Blood Dyscrasias. Hamilton, Illinois: Drug Intelligence Publications; 1977. Google Scholar3. KAUFFMANFRAME CP. Bone marrow toxicity associated with 5-fluorocytosine therapy. Antimicrob Agents Chemother. 1977;11:244-47. CrossrefMedlineGoogle Scholar4. KOEFFLERGOLDE HD. Amphotericin inhibition of hematopoiesis in vitro. Am J Hematol. 1977;3:57-62. CrossrefMedlineGoogle Scholar5. BANDRISS M. Anemia induced by amphotericin. Ann Intern Med. 1969;61:343-4. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CLARA S. P. CHAN, M.D.; CARMELITA U. TUAZON, M.D.; LAWRENCE S. LESSIN, M.D.Affiliations: George Washington University Medical Center Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA meta-analysis of risk factors associated with platelet transfusion refractorinessPolyenes and Amphotericin BBleeding and Thrombosis in Hematologic NeoplasiaAmphotericinHematological toxicities associated with amphotericin B formulationsToxicokinetic and mechanistic basis for the safety and tolerability of liposomal amphotericin BBleeding and Thrombosis in Hematologic NeoplasiaANTIFUNGAL DRUGSYEAST AND FUNGAL INFECTIONS OF THE FETUS AND NEONATEAntibacterial and Antifungal AgentsAmphotericinCaspofungin: A Potential Cause of Reversible Severe ThrombocytopeniaAgents for treatment of invasive fungal infectionsThrombopénie induite par l'amphotéricine B chez un très grand prématuré avec candidose congénitaleThrombocytopenia in Intensive Care Patients: A Comprehensive Analysis of Risk Factors in 314 PatientsAmphotericin BCandida: An Increasingly Important Pathogen in the NurseryAntimicrobial TherapyAntifungal drugsToxicity of amphotericin B, miconazole, and ketoconazole to human granulocyte progenitor cells in vitro 1 March 1982Volume 96, Issue 3Page: 332-333KeywordsAdverse reactionsAmphotericinAnemiaChemotherapyHematology and oncologyHypomagnesemiaSepsisToxicity ePublished: 1 December 2008 Issue Published: 1 March 1982 PDF downloadLoading ...