tbuckley/cabot-search huggingface dataset:
Abstract 5157: A role of the FGF-pathway in the VEGF/VEGFR targeting
Authors: Ilya Tsimafeyeu, Lev Demidov, Nygel Wynn
Journal: Cancer Research (2011)

Abstract Background: The growth of new blood vessels is regulated at multiple steps by interactions between several pro- and antiangiogenic factors. We believe that the angiogenesis induced by basic fibroblast growth factor (bFGF) is resistant to anti-VEGF/VEGFR (vascular endothelial growth factor/receptor) therapy. Methods: The Corneal Micro Pocket Assay was performed. 70 Charles River female C57BL/6 mice (age at start day, 6 weeks) were randomized to 7 arms (10 mice in each group): 1) bFGF; 2) VEGF-A; 3) bFGF negative, VEGF-A negative; 4) bFGF and sunitinib; 5) VEGF-A and sunitinib; 6) bFGF and bevacizumab; 7) VEGF-A and bevacizumab. Doses of bFGF, VEGF-A (R&amp;D Systems), sunitinib (Pfizer), and bevacizumab (Roche) were 200 ng, 400 ng, 10 mg/kg, 50 mg/kg per animal, respectively. Hydron pellets preparation, surgical procedure, and quantification of angiogenesis (angiogenic score) were performed as previously reported (Kenyon BM et al.). Statistical significance was determined by the Student's t test. Results: There was no neovascularization in bFGF negative, VEGF-A negative group (mean, 0). The effect of 200 ng/pellet of bFGF (mean, 4.2; SEM, 0.05) was compared with that of 400 ng/pellet VEGF-A (mean, 4.08; SEM, 0.09), P=0.7. In bFGF-induced angiogenesis, sunitinib (mean, 3.9; SEM, 0.1; P=0.2) and bevacizumab (mean, 4.71; SEM, 0.33; P=0.85) did not impact on neovascularization in comparison with bFGF positive control. The angiogenic effect of VEGF-A was significantly inhibited by both sunitinib (mean, 0.38; SEM, 0.06; P=0.001) and bevacizumab (mean, 0.75; SEM, 0.05; P=0.001) in comparison with VEGF-A positive control. No significant differences between 2 targeted agents in bFGF and VEGF-A models were obtained. Conclusion: Our recent findings demonstrate that anti-VEGF(R) therapy significantly impacts on VEGF-A-induced angiogenesis and not on bFGF-induced neovascularization. Further studies are needed to assess the role of FGF-pathway in resistance to VEGF(R) therapy. The study was supported by Terry Fox Foundation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5157. doi:10.1158/1538-7445.AM2011-5157
Community care has led to loss of staff from psychiatric wards
Authors: Andrew Cole
Journal: BMJ (2005)

A new report indicates that the growing emphasis on caring for mental health patients in the community is having a serious effect on hospital care, leading to an exodus of staff and worsening conditions for inpatients.

The survey, by the Sainsbury Centre for Mental Health, was commissioned by the National Institute for Mental Health in England and is one of the most detailed assessments of hospital care ever carried out in England, covering more than 50 trusts and 300 wards.

Nearly a third of ward managers reported that their patients were now more severely ill and had higher levels of …
In vivo formation and persistence of modified nucleosides resulting from alkylating agents.
Authors: B Singer
Journal: Environmental Health Perspectives (1985)

Alkylating agents are ubiquitous in the human environment and are continuously synthesized in vivo. Although many classes exist, interest has been focused on the N-nitroso compounds, since many are mutagens for bacteria, phage, and cells, and carcinogens for mammals. In contrast to aromatic amines and polyaromatic hydrocarbons which can react at carbons, simple alkylating agents react with nitrogens and oxygens: 13 sites are possible, including the internucleotide phosphodiester. However, only the N-nitroso compounds react extensively with oxygens. In vivo, most possible derivatives have been found after administration of methyl and ethyl nitroso compounds. The ethylating agents are more reactive toward oxygens than are the methylating agents and are more carcinogenic in terms of total alkylation. This is true regardless of whether or not the compounds require metabolic activation. It has been hypothesized that the level and persistence of specific derivatives in a
Abstract 5021: Native accessible ChIP: A novel approach to interrogate protein-DNA interactions in accessible chromatin
Authors: Steven T. Okino, Xiangdong Meng, Michelle Kong, Yan Wang
Journal: Cancer Research (2012)

Abstract Recently we developed novel technology for isolating accessible chromatin. When cells are permeabilized and treated with nuclease in situ, small DNA fragments, corresponding to accessible chromatin can be easily isolated and characterized. These DNA fragments, when analyzed by next-generation sequencing, provide a global map of accessible chromatin. We now report that the accessible chromatin isolated from cells is still associated with its cognate DNA-binding proteins and histones. Based on this, we developed a novel chromatin immunoprecipitation (ChIP) assay that does not require protein-DNA cross-linking or DNA shearing. Using this method, termed NA-ChIP (for native accessible ChIP), we demonstrate that RNA polymerase II (RNAPII), TBP and H3K4me3 are all associated with active promoters, but are rarely detected at silenced promoters. Comparison of NA-ChIP and a standard ChIP assay shows that immunoprecipitation (IP) efficiency is similar, but IP specificity is dramatically different. To measure IP specificity we compared the ratio of active promoter DNA precipitated with RNAPII (signal) relative to inactive promoter DNA precipitated (noise). We find that NA-ChIP is highly specific with a signal-to-noise ratio &amp;gt;500; standard ChIP is less specific with a signal-to-noise ratio of about 9. We conclude that NA-ChIP offers significant advantages over standard ChIP, including dramatically reduced background and an easier workflow. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5021. doi:1538-7445.AM2012-5021
An Abundance of Urine
Authors: Leonard B. Berman
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Twenty-four-hour Cortisol Profiles Demonstrate Exaggerated Nocturnal Rise in Diabetic Children
Authors: Tessa G Lebinger, Paul Saenger, David K Fukushima, Jacob Kream, Richard Wu, Jordan W Finkelstein
Journal: Diabetes Care (1983)

Plasma cortisol was measured every 20 min for 24 h in 12 normal and 8 insulin-dependent, nonketotic, diabetic children treated with one daily injection of insulin. Plasma glucose was also measured every 20 min in the diabetic children. The diurnal pattern of cortisol secretion was identical. The mean 24- h plasma cortisol was similar in both groups, but significantly elevated in the diabetic children between 0200 and 0920 h. Peak cortisol levels were higher in the diabetic than in the normal children. No correlation was found between average plasma glucose and average plasma cortisol, or between the nocturnal change in plasma glucose and average nocturnal plasma cortisol in the diabetic subjects. These studies demonstrate an exaggeration of the normal nocturnal rise in plasma cortisol in diabetic children not related to the levels of plasma glucose.
TWO CASES OF ECTOPIC GESTATION.
Authors: E. E. GELDER
Journal: JAMA (1907)

As tubal pregnancy must often times be diagnosed from the history rather than by physical findings, a complete history of each case should be reported. Each specimen removed at operation or autopsy should be studied to ascertain, if possible, the cause of failure of the impregnated ovum to descend the tube and enter the uterus. In pursuance of these ideas I make this report. <h3>Case 1.</h3> —In July 1906, I saw this woman at her home, in consultation with her physician, Dr. W. H. Willis of this city, and obtained the following history: <h3>History.</h3> —Mrs. —, aged 30, had been married nine years but had not been pregnant previously. Her menstrual periods had always been regular, not painful, and the flow normal in quantity and duration. She never had intermenstrual bleeding or leucorrhea, and never had symptoms referable to inflammatory or infectious disease or any of the pelvic viscera. In
Dialysis in Treatment of Neomycin Overdosage
Authors: Frank A. Krumlovsky, Janet Emmerman, Richard H. Parker, Max Wisgerhof, Francesco Del Greco
Journal: Annals of Internal Medicine (1972)

A 39-year-old woman developed severe nephrotoxicity secondary to neomycin overdosage. A moderately high dialysance of neomycin was demonstrated. Hemodialysis is an effective method of therapy for neomycin overdosage, especially in the presence of renal insufficiency. Previously described techniques for neomycin assay have been significantly improved.
Effect of alterations of dietary sodium on the severity of asthma in men.
Authors: O J Carey, C Locke, J B Cookson
Journal: Thorax (1993)

BACKGROUND--There is some evidence of a positive association between increased dietary salt consumption and both increased bronchial reactivity and mortality from asthma in men. This study assesses the effects of alterations in dietary salt consumption on the clinical severity of asthma in adult male asthmatic patients. METHODS--A randomised, double blind, placebo controlled, crossover design was employed. Twenty seven mild to moderate asthmatic patients were established on a low sodium diet (80 mmol/day) at the end of a 4-5 day run in period and then randomised to receive 200 mmol/day slow sodium or matching placebo for five weeks, crossing over to the alternative regime for a further five weeks. Patients used diary cards to record twice daily peak expiratory flow rates, daily symptom scores, and bronchodilator consumption. Spirometry and degree of bronchial responsiveness (methacholine challenge test) were measured at screening and at the end of each treatment period. Twenty four hour urinary sodium excretion was measured at screening and in duplicate for each treatment period. RESULTS--Twenty two patients completed the study. For these patients the mean (95% confidence interval (CI)) difference in 24 hour sodium excretion between treatments was 204 (175 to 235) mmol. Compared with placebo, sodium supplementation resulted in deleterious alterations of all measured parameters. Bronchial reactivity rose on slow sodium with a 0.73 (0.2 to 1.3) doubling dose methacholine difference compared with placebo. Estimated median (95% CI) difference in bronchodilator consumption was 1.3 (0.4 to 2.1) puffs per day, the estimated median difference in symptom score was 0.6 (0.2 to 0.9), and mean forced expiratory volume in one second fell by 0.21 (0.05 to 0.37) 1. The peak expiratory flow rate rose on placebo and fell on slow sodium. Median differences between treatments were 5.6% (2.2% to 9.8%) for morning and 7.8% (3.9% to 12.9%) for evening peak expiratory flow rate. CONCLUSIONS--Our results suggest that large increases in dietary sodium result in physiological deterioration and increased morbidity in male asthmatic patients.
Probabilistic application of plasma carcinoembryonic antigen assay in cancer patients.
Authors: L K Ashman, J Ludbrook, V R Marshall
Journal: BMJ (1975)

Plasma carcinoembryonic antigen (C.E.A.) levels in inpatients proved at necropsy to be cancer free were used to assess the ability of the C.E.A. assay to distinguish benign and malignant disease. The patients had a mean C.E.A. level significantly greater than that for young healthy people. In view of the considerable overlap of the ranges of plasma C.E.A. concentration in cancer patients and patients with non-malignant disease a probabilistic interpretation is advocated rather than the use of a simple cut-off between positive and negative. On the basis of the cancer-free control group, 19 out of 64 untreated patients with various solid tumours had plasma C.E.A. levels considered to correspond to a greater than 95% probability of cancer.
Permanent repigmentation of piebaldism by erbium:YAG laser and autologous cultured epidermis
Authors: L. Guerra, G. Primavera, D. Raskovic, G. Pellegrini, O. Golisano, S. Bondanza, S. Kuhn, P. Piazza, A. Luci, F. Atzori, M. De Luca
Journal: British Journal of Dermatology (2004)

Several surgical techniques have been proposed for the treatment of piebaldism. These procedures, however, are poorly suited for the treatment of large leucodermal lesions, can cause scars and require multiple donor sites. Recently, it has been reported that autologous cultured epidermis induces scarless repigmentation of large vitiligo lesions, using a single small donor site.To induce permanent repigmentation of large achromic lesions in patients suffering from piebaldism by means of autologous cultured epidermal grafts using a rapid, simple and non-invasive surgical procedure.Six patients with piebaldism were enrolled in this study. Achromic epidermis was removed by means of appropriately set erbium:YAG laser and autologous cultured epidermal grafts were applied on to the recipient bed. Melanocyte content was evaluated by 3,4-dihydroxyphenylalanine reaction. The percentage of repigmentation was calculated using a semiautomatic image analysis system.Autologous cultured epidermis, bearing a controlled number of melanocytes, induced repigmentation of all piebald lesions. The mean percentage repigmentation was 95.45% (2791.5 cm2 repigmented/2924.2 cm2 transplanted).Autologous cultured epidermal grafts induce permanent and complete repigmentation of piebald lesions, in the absence of scars. Erbium:YAG laser surgery is a rapid and precise tool for disepithelialization, hence allowing treatment of large piebald lesions during a single surgical operation.
An Address ON THORACIC ANEURYSM: Delivered before the Cleveland Division of the British Medical Association at Ormesby Hospital, Middlesbrough
Authors: T. Oliver
Journal: BMJ (1907)

WHEN YOU did me the honour of inviting.meto give a lecture, and suggested as a title Thoracic Aneurysm, I felt that this was a subject which we in this particular part, the north-east coast of England, had many opportunities of seeing and treating, and, therefore, of expressing an opinion upon.Thoracic aneurysm may be one of the simplest diseases to diagnose-it may also be one of the most -difficult.There is a type of aneurysm which is recognized by physical signs and another mainly by symptoms.Occasionally the disease is present without giving rise to any complaint on the part of 4a patient.A ruptured aneurysm is occasionally found at the pos8tmortem examination of persons who have died suddenly.Men are more liable -to -thoracic aneurysm than women.The proportion is given as nine males.to one female, but in the Newcastle Infirmary it is probably nearer twelve.than nine.It is a malady that affects men in the early part of the prime of life.Taking at random 17 cases of thoracic aneurysm from'our infirmary patients I find that 12.were men between the ages of 35 and 45, 4 were between 45 and 55, while 3 of the men affected were between 55 and 60.Et is during the strenuous part of a man's life that the diseased wall of the aorta yields before the strain to which it is exposed, the change commencing in the intima but outstripped in the course of time by the middle coat becoming the more affected.Aneurysms are spoken of as fusiform and sacculated.In afusiform aneurysm a segment of an artery is more or less regularly distended throughout its circumference, and it is spindle-shaped; but a sacculated aneurysm, formed as it is'by a dilatation of a particular portion of the wall of an artery, is often in appearance not unlike a diverticulum of the-intestine.It is in sacculated aneurysms that the middle'.coat of the vessel is found to have become thinned out in many instances to disappearance, and in which the interior is lined by laminated clotted blood, the layers next the wall of the aneurysm being pale and stratified, while internal to this the blood clot is red and -soft.Sometimes,' as in the drawing I show you, a crack occurs in the intimaof the aorta and penetrates into the middle coat,often
Turning over a new leaf. Tobacco.
Authors: B E Fisher
Journal: Environmental Health Perspectives (1999)

Anticipating a diminishing market for cigarettes and other tobacco products in the future, researchers around the country are studying alternative uses for tobacco plants. The most promising field of research for tobacco involves the genetic engineering of tobacco plants to produce various substances such as industrial chemicals, pharmaceuticals, and consumer product ingredients. Tobacco has been called the "fruit fly of the plant kingdom" because of the ease with which it can be genetically engineered. There are countless possibilities for the use of tobacco, but current efforts are concentrating on engineering tobacco to produce vaccines, human enzymes, and plastics. Tobacco researchers have been successful in expressing bovine lysozyme, an enzyme with antibacterial properties, and insulin.
983-33 Safety Evaluation of a New Infusion-Perfusion Catheter: Vectocardiographic, Left Ventricular and Coronary Hemodynamic During Local Drug Delivery
Authors: Edoardo Camenzind, Carlo di Mario, Jurgen Ligthart, Peter de Jaegere, Pim de Feyter, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (1995)
Inhibition of microsomal glucose-6-phosphate transport in human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction in glycogen storage disease type 1b
Authors: Rosanna Leuzzi, Gábor Bánhegyi, Tamás Kardon, Paola Marcolongo, Piero-Leopoldo Capecchi, Hans-Joerg Burger, Angelo Benedetti, Rosella Fulceri
Journal: Blood (2003)
Cobalt-57-bleomycin scanning of hila and mediastinum in patients with bronchial carcinoma: a prospective study.
Authors: J J Rasker, H Beekhuis, A M van de Wal, J N Homan van der Heide, M G Woldring
Journal: Thorax (1976)

Because the results with cobalt-57-bleomycin (57Co-bleo) as a tumour-seeking agent in patients with pulmonary tumours were promising, a prospective study was carried out to test the sensitivity and selectivity of this technique for metastases in lung hila and mediastinum in a group of patients with bronchial cancer. The sensitivity of 57Co-bleo scintigraphy appeared to be higher than that of routine radiological investigations and mediastinoscopy. For this reason it is suggested that 57Co-bleo scintigraphy can be used as a method to select patients for mediastinoscopy.
Serum levels of seven cytokines in premature ventilated newborns: correlations with old and new forms of bronchopulmonary dysplasia
Authors: Giovanni Vento, Ettore Capoluongo, Piero G. Matassa, Paola Concolino, Valentina Vendettuoli, Cinzia Vaccarella, Simona Frezza, Cecilia Zuppi, Costantino Romagnoli, Franco Ameglio
Journal: Intensive Care Medicine (2006)
Comparative Imaging
Authors: BRUCE A. SCHROEDER, ROBERT G. WELLS, JOHN R. STY
Journal: Clinical Nuclear Medicine (1987)

Approximately 5% of pheochromocytomas present during childhood. Pheochromocytomas in children occur in an extra-adrenal location in approximately 30% of cases. The majority of extra-adrenal pheochromocytomas occur in the organ of Zuckerkandl (near the aortic bifurcation), within the bladder wall, or along the course of the ureters. Comparative imaging in extra-adrenal pheochromocytoma is illustrated in a 4-year-old female. At operation an extra-adrenal pheochromocytoma was removed from a paraspinous location medial to the lower pole of the left kidney.
Measuring quality of life in epidermolysis bullosa in Mexico: Cross-cultural validation of the Hispanic version of the Quality of Life in Epidermolysis Bullosa questionnaire
Authors: John W. Frew, Rodrigo Cepeda Valdes, Giulio Fortuna, Dedee F. Murrell, Julio Salas Alanis
Journal: Journal of the American Academy of Dermatology (2013)
MORE ON DUPLICATE ABSTRACTS AND FILING
Authors: ISTVÁN KRISKÓ
Journal: Annals of Internal Medicine (1968)

ExcerptTo the Editor:Allow me to thank you for writing the editorial "Where Did I See That Paper?" (ANNALS OFINTERNALMEDICINE, August 1967) Having just gone through some small agonies of decision-making about my filing "system," I find your thoughts and advice both comforting and stimulating. I suppose my liking of your editorial in a way is similar to our appreciation of Shakespeare: Hamlet not only speaks to us, but at times he speaks for us....
Thromboembolism After Hip Reconstruction
Authors: J. George Sharnoff
Journal: JAMA (1973)

To the Editor.—  I was sorry to see the result reported by Evarts and Alfidi inThe Journal(225:515, 1973) on heparin prophylaxis of total hip reconstruction. I note that they have used Mr. Kakkar's program and not the one advocated by me.1His is a dangerous modification of my program and has created difficulties, as admitted by Mr. Kakkar2and by Mr. Charnley. Furthermore, Mr. Charnley has told me  know that dextran doesn't work. I, on the other hand, guided by the findings of the pulmonary megakaryocytes and heparin controlled by the Dale and Laidlaw coagulometer, have experienced little difficulty. With my program giving 10,000 units of aqueous heparin subcutaneously the midnight before surgery and continuing postoperative small doses every six hours, not for just five to seven days as Mr. Kakkar recommends but until full reactivation or discharge, we have not had problems of hemorrhage
Pericardial Calcification Associated with Histoplasmosis
Authors: J. K. Hurwitz, Bernard H. Pastor
Journal: New England Journal of Medicine (1959)

HISTOPLASMOSIS is known to involve many tissues, but pericardial involvement has rarely been reported. Since histoplasmosis is a generalized infection of the reticuloendothelial system, with proliferation of the parasitic form of the fungus within the cells,1 it seems unlikely that it would spare the pericardium. We have recently seen a patient with a calcified pericardium that we believe to be due to histoplasmosis.Case ReportA 50-year-old man was admitted to the Ophthalmology Ward of the Philadelphia Veterans Administration Hospital on April 2, 1958, because of blurring of vision in the left eye. He had noted decreased vision intermittently since . . .
Intake of macronutrients and risk of breast cancer
Authors: S. Franceschi, A. Favero, A. Russo, A. Decarli, C. La Vecchia, M. Ferraroni, A. Decarli, E. Negri, C. La Vecchia, D. Amadori, E. Conti, M. Montella, A. Giacosa
Journal: The Lancet (1996)