tbuckley/cabot-search huggingface dataset:
STUDIES ON ACHILLES TENDINOSIS: BILATERAL RECOVERY AFTER UNILATERAL SURGERY, AND SIMILAR HISTOPATHOLOGICAL APPEARANCES BILATERALLY
Authors: H Alfredson, C Spang, S Forsgren
Journal: British Journal of Sports Medicine (2013)

It is frequently observed that midportion Achilles tendinopathy/tendinosis occurs bilaterally. With this as a background, the outcome of unilateral operations was evaluated in 13 patients (seven males and six females) with chronic painful bilateral midportion Achilles tendinopathy (tendinosis) (symptom duration: 6–12 months). Prolonged periods of rest did not have an effect. As surgical treatment, an ultrasound and Doppler-guided scraping procedure outside the ventral part of the tendon was performed in local anaesthesia, a method that recently has been found to be successful for patients with Achilles tendinosis. Surgical treatment was performed only on one side, the other side being left untreated. The patients started walking on the first day after surgery, and were followed over time. In an additional part of the study, specimens from Achilles and plantaris tendons in 3 patients with bilateral Achilles tendinosis were examined. Follow-ups showed postoperative improvement also on the non-operated side in 11/13 patients, and a final follow up after 37 (mean) months showed significant pain relief and patient satisfaction on both sides for these 11 patients. In 2/13 patients, operation on the other, initially non-operated side, was needed. Morphologically, it was found that there were similar morphological characteristics and similar immunohistochemical patterns concerning enzymes involved in signal substance production bilaterally, the microscopic findings being in line with previous information from tendinosis tendons. It can be concluded that the structural affections are similar on both sides in bilateral Achilles tendinosis. The study showed that unilateral operative treatment can also have benefits contra-laterally. A hypothesis is that unilateral influences on the sensory innervation in the peritendinous tissue in response to the scraping operation have secondary effects contralaterally, that is, influences on the pattern of primary-afferent activation on one side can have effects contra-laterally. The interpretation concerning a presumable cross-talk between right and left sides are in line with the results of recent experimental studies in animals showing that tendinosis-like features occur bilaterally in the Achilles tendons in response to unilateral overuse, suggesting that there is an involvement of central neuronal mechanisms. The observations of bilateral effects in response to unilateral treatment have clinical implications.
Clofazimine in the treatment of discoid lupus erythematosus
Authors: J.P. MACKEY, J. BARNES
Journal: British Journal of Dermatology (1974)

Clofazimine, a rimino-phenazine dye with immunosuppressive activity, was employed in the treatment of twenty-six cases of chronic discoid lupus erythematosus. Seventeen of these cases went into remission.
Chemokine receptor expression profile of eosinophils in disordered conditions
Authors: Hiroyuki Nagase, Koichiro Kudo, Shinyu Izumi, Ken Ohta, Nobuyuki Kobayashi, Masao Yamaguchi, Kouji Matsushima, Yutaka Morita, Kazuhiko Yamamoto, Koichi Hirai
Journal: Journal of Allergy and Clinical Immunology (2002)
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
Authors: Laura J. Blair, Bryce A. Nordhues, Shannon E. Hill, K. Matthew Scaglione, John C. O’Leary, Sarah N. Fontaine, Leonid Breydo, Bo Zhang, Pengfei Li, Li Wang, Carl Cotman, Henry L. Paulson, Martin Muschol, Vladimir N. Uversky, Torsten Klengel, Elisabeth B. Binder, Rakez Kayed, Todd E. Golde, Nicole Berchtold, Chad A. Dickey
Journal: Journal of Clinical Investigation (2013)

Aggregation of tau protein in the brain is associated with a class of neurodegenerative diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by FKBP5) forms a mature chaperone complex with Hsp90 that prevents tau degradation. In this study, we have shown that tau levels are reduced throughout the brains of Fkbp5-/- mice. Recombinant FKBP51 and Hsp90 synergized to block tau clearance through the proteasome, resulting in tau oligomerization. Overexpression of FKBP51 in a tau transgenic mouse model revealed that FKBP51 preserved the species of tau that have been linked to Alzheimer's disease (AD) pathogenesis, blocked amyloid formation, and decreased tangle load in the brain. Alterations in tau turnover and aggregate structure corresponded with enhanced neurotoxicity in mice. In human brains, FKBP51 levels increased relative to age and AD, corresponding with demethylation of the regulatory regions in the FKBP5 gene. We also found that higher FKBP51 levels were associated with AD progression. Our data support a model in which age-associated increases in FKBP51 levels and its interaction with Hsp90 promote neurotoxic tau accumulation. Strategies aimed at attenuating FKBP51 levels or its interaction with Hsp90 have the potential to be therapeutically relevant for AD and other tauopathies.
Rosuvastatin increases insulin sensitivity and reduces atherosclerotic plaque volume and plaque macrophage and oxidized LDL content in obese dyslipidemic mice in the absence of cholesterol reduction
Authors: Wim Verreth, Jean-Luc Balligand, Dieuwke De Keyzer, Penelope Davey, Ann Mertens, Marie-Christine Herregods, Graham Smith, Fanny Desjardins, Paul Holvoet
Journal: Circulation (2006)
Electron microscopic and immunological evidence of nanobacterial-like structures in calcified carotid arteries, aortic aneurysms, and cardiac valves
Authors: Todd E. Rasmussen, Brenda L. Kirkland, Jon Charlesworth, George Rodgers, Sandra R. Severson, Jeri Rodgers, Robert L. Folk, Virginia M. Miller
Journal: Journal of the American College of Cardiology (2002)
Low-Energy Cardioversion of Spontaneous Atrial Fibrillation
Authors: Samuel Lévy, Philippe Ricard, Max Gueunoun, Florence Yapo, Jacques Trigano, Chadia Mansouri, Franck Paganelli
Journal: Circulation (1997)

Background Recent studies have suggested that induced atrial fibrillation (AF) could be successfully terminated by using a two-catheter electrode system and low energy (&lt;400 V). This study evaluated the efficacy and safety of low-energy cardioversion in spontaneous chronic and paroxysmal AF. Methods and Results Forty-two consecutive patients with spontaneous AF underwent low-energy electrical cardioversion. AF was chronic (≥1 month) with a mean duration of 9±19 months in 28 patients (group I) or paroxysmal with a history of recurrent attacks and a mean duration of the present episode of 7±16 days in 14 patients (group II). An underlying heart disease was present in 28 patients. A 3/3-ms biphasic shock was delivered between catheters positioned in the right atrium and the coronary sinus in 32 patients. In 10 patients, the left pulmonary artery branch was used. The catheters were connected to a custom external defibrillator. The shocks were synchronized to the R wave. Following a test shock of 60 V, the energy was increased in 40-V steps until a maximum of 400 V or restoration of sinus rhythm. Sinus rhythm was restored in 22 of the 28 patients (78%) of group I by using a mean leading-edge voltage of 297±57 V (mean energy, 3.3±1.3 J) and in 11 of 14 patients (78%) of group II by using a mean leading-edge voltage of 223±41 V (mean energy, 1.8±0.7 J). The energy required for terminating chronic AF was significantly ( P &lt;.001) higher than that required for terminating paroxysmal AF. Among the other variables studied, the duration of AF significantly affected the successful voltage. Ventricular proarrhythmia occurred in 1 patient with atrial flutter due to an unsynchronized shock. Of the 22 patients of group I in whom sinus rhythm was restored, 14 (63%) remained in sinus rhythm with a mean follow-up of 9±3 months. Pain level showed a good correlation with increasing voltage. However, a marked interindividual variation was noted. Conclusions Atrial defibrillation using low energy between two intracardiac catheters with an electrical field between the right and left atria and the protocol used is feasible in patients with persistent spontaneous AF. The technique is safe provided synchronization to the R wave is achieved. A low recurrence rate of AF was seen in patients in whom sinus rhythm was restored.
The Chemokine Receptor CXCR6 Controls the Functional Topography of Interleukin-22 Producing Intestinal Innate Lymphoid Cells
Authors: Naoko Satoh-Takayama, Nicolas Serafini, Thomas Verrier, Abdessalem Rekiki, Jean-Christophe Renauld, Gad Frankel, James P Di Santo
Journal: Immunity (2014)
Novel natrluretic peptide receptor A genetic variant associated with higher blood pressure values in normotensive subjects
Authors: Maria V. Pitzalis, Paolo Dessi-Fulgheri, Sandro Sorrentino, Cinzia Forleo, Riccardo Sarzani, Fabio Salvi, Pietro Guida, Massimo Iacoviello, Katia Lucarelli, Alessandro Rappelli, Paolo Rizzon
Journal: Journal of the American College of Cardiology (2002)
Review: Calprotectin testing differentiates inflammatory bowel disease from the irritable bowel syndrome
Authors: Paul Moayyedi
Journal: Annals of Internal Medicine (2014)

Source Citation Waugh N, Cummins E, Royle P, et al. Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation. Health Technol Assess. 2013;17:xv-xix, 1-211. [Epub ahead of print] 24286461
Early and Midterm Clinical Experience of 3-Dimensional Saddle Shape Rigid Annuloplasty Ring in Mitral Valve Repair
Authors: Sabit Sarıkaya, Eray Aksoy, Özge Altaş Yerlikhan, Mehmet Dedemoğlu, Akın Arslan, Ahmet Elibol, Deniz Günay, Ekin Can Çelik, Kaan Kırali
Journal: Journal of the American College of Cardiology (2013)
Combined Continuous Subcutaneous Insulin Infusion and Multiple Subcutaneous Injections in Type I Diabetic Patients
Authors: Alicia Schiffrin, Mimi Belmonte
Journal: Diabetes Care (1981)

Seven insulin-dependent diabetic patients (aged 16–34 yr) were treated for 10 mo with a combination of continuous subcutaneous insulin infusion (CSII) during the night and premeal boluses of insulin during the day. The technology and strategy of the system are discussed. Three of these patients had been on CSII for 1 yr before the start of this study. Mean fasting (126 ± 44 mg/dl), mean preprandial blood glucose (131 ± 54 mg/dl), and mean postprandial blood glucose (216 ± 73 mg/dl) before starting this treatment fell to 86 ± 12 mg/dl, 83 ± 19 mg/dl, and 132 ± 1 7 mg/dl, respectively, after 1 mo of treatment. Glycosylated hemoglobin (10,8 ± 2.9% before the study) reached normal values (7.8 ± 0.6%) after 2 mo of treatment. Improvement of glycemic control may be achieved with this form of insulin administration, which is of immediate practical application, until an ideal system of insulin delivery becomes available. This technique provides the conditions for testing the hypothesis that near normalization of glycemic control prevents or minimizes the degenerative complications associated with diabetes mellitus.
THE RELATIONSHIP BETWEEN THE VASCULAR MANIFESTATIONS OF SHOCK PRODUCED BY ENDOTOXIN, TRAUMA, AND HEMORRHAGE
Authors: Benjamin W. Zweifach, Lewis Thomas
Journal: The Journal of Experimental Medicine (1957)

The vascular effects of lethal doses of E. coli endotoxin, as observed in the mesentery of the rat, resemble the reactions of traumatic and hemorrhagic shock in the following respects: a profound inhibition of arteriolar and precapillary reactivity to topical epinephrine occurs after an initial stage of hyperreactivity; the small veins show failure to relax completely following constrictor doses of epinephrine; and the terminal vessels develop an unusual sensitivity to fluctuations in temperature of the fluid irrigating the tissue. Rats in which tolerance to bacterial endotoxin is induced, by repeated doses given daily, become highly resistant to the lethal effects of both drum trauma and hemorrhagic shock. However, rats in which the adaptation to traumatic shock is produced by repeated exposure to drum trauma, do not develop a significant degree of tolerance to lethal doses of endotoxin. The injection of small non-lethal doses of bacterial endotoxin during non-lethal episodes of trauma or hemorrhage, leads to the development of irreversible shock and death. The bearing of these findings on the problem of the relationship between endotoxin and traumatic shock is discussed.
Health technology assessment in universal health coverage
Authors: Kalipso Chalkidou, Robert Marten, Derek Cutler, Tony Culyer, Richard Smith, Yot Teerawattananon, Francoise Cluzeau, Ryan Li, Richard Sullivan, Yanzhong Huang, Victoria Fan, Amanda Glassman, Yu Dezhi, Martha Gyansa-Lutterodt, Sam McPherson, Carlos Gadelha, Thiagarajan Sundararaman, Neil Squires, Nils Daulaire, Rajeev Sadanandan, Konuma Shiro, Alexandre Lemgruber
Journal: The Lancet (2013)
Unstable Rest Angina with ST-Segment Depression
Authors: PHILIP B. OLIVA
Journal: Annals of Internal Medicine (1984)

Because of recent findings, a reassessment is needed of the concept that rest angina associated with ST-segment depression is due to a spontaneous, transient increase of blood pressure or heart rate, or both, in the presence of critical coronary artery stenosis. Continuous hemodynamic and electrocardiographic recordings done before and during attacks of rest angina and thallium-201 scintigrams done during pain indicate that a transient reduction of flow is the immediate cause of ischemia in most, but not all, instances. Flow reduction, in turn, appears to be due to coronary arterial spasm or platelet aggregation, or both, acting at a site of atherosclerotic narrowing. Therapy for unstable rest angina should include measures to prevent both transient reductions of flow and increases of myocardial oxygen consumption. A combination of long-acting nitrates, a beta-blocker, a calcium-channel blocker, and aspirin or heparin is suggested for this purpose. Intravenous nitroglycerin is useful when angina occurs despite this therapy or when frequent attacks of ischemia are occurring at the time of admission.
Abstract 1146: A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small cell lung cancer
Authors: Yi Young Choi
Journal: Cancer Research (2012)

Abstract Introduction: The 15q25 region was associated with lung cancer risk and might be associated with prognosis of lung cancer. This study was conducted to determine the impact of a functional polymorphism in the CHRNA3 gene on chromosome 15q25 on the survival of patients with early stage non-small cell lung cancer (NSCLC). Methods: Five hundred eighty-three consecutive patients with surgically-resected NSCLC were enrolled. The rs6495309C&amp;gt;T polymorphism in the promoter of the CHRNA3 gene was investigated. The association between genotype and overall survival and disease-free survival was analyzed. Results: Patients with the rs6495309 CT or TT genotype had a significantly better OS and DFS than the rs6495309 CC genotype (adjusted hazard ratio for overall survival = 0.56, 95% confidence interval = 0.41-0.75, P = 0.0001; and adjusted hazard ratio for disease-free survival = 0.61, 95% confidence interval = 0.48-0.79, P = 0.0001). An association between the rs6495309C&amp;gt;T polymorphism and survival outcome was demonstrated in smokers and never-smokers, and in squamous cell carcinomas and adenocarcinomas. Conclusion: The CHRNA3 rs6495309C&amp;gt;T polymorphism may affect survival in patients with early-stage NSCLC. Analysis of the rs6495309C&amp;gt;T polymorphism can help identify patients at high risk of a poor disease outcome. Key words: CHRNA3, polymorphism, non-small cell lung cancer, survival Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1146. doi:1538-7445.AM2012-1146
Paediatricians propose plan to insure every US child
Authors: S. Gottlieb
Journal: BMJ (1999)

The American Academy of Pediatrics announced a new health insurance proposal that would create a national programme in the United States in which all children and young people up to the age of 21 are automatically eligible for full, government funded healthcare coverage. At present, 11 million children are not covered by insurance.

The new programme would have uniform eligibility and benefits, and if enacted, would replace a patchwork of existing programmes that provide partial but not complete …
Treatment of Life-Threatening Digitalis Intoxication with Digoxin-Specific Fab Antibody Fragments
Authors: Thomas W. Smith, Vincent P. Butler, Edgar Haber, Harry Fozzard, Frank I. Marcus, W. Fraser Bremner, Ira C. Schulman, Anthony Phillips
Journal: New England Journal of Medicine (1982)

Purified Fab fragments of digoxin-specific antibodies obtained from sheep were used to treat 26 patients with advanced, life-threatening digoxin (23 cases) or digitoxin (3 cases) toxicity. These patients had advanced cardiac arrhythmias, and in some cases hyperkalemia, which were resistant to conventional treatment. All patients had an initial favorable response to doses of Fab fragments calculated (in most cases) to be equivalent, on a molar basis, to the amount of cardiac glycoside in the patient's body. In four patients treated after prolonged hypotension and low cardiac output, death ensued from cerebral or myocardial hypoperfusion. In one case the available Fab fragment supply was inadequate to reverse a massive suicidal ingestion of digoxin, and the patient died after recurrent ventricular arrhythmias. In the remaining 21 patients, cardiac rhythm disturbances and hyperkalemia were rapidly reversed, and full recovery ensued. There were no adverse reactions to the treatment. We conclude that the use of purified digoxin-specific Fab fragments is a safe and effective means to reverse advanced, life-threatening digitalis intoxication.
Body Dissatisfaction and Its Interrelations with Other Risk Factors for Bulimia nervosa in 12 Countries
Authors: B. Jaeger, G.M. Ruggiero, B. Edlund, C. Gomez-Perretta, F. Lang, P. Mohammadkhani, C. Sahleen-Veasey, H. Schomer, F. Lamprecht
Journal: Psychotherapy and Psychosomatics (2001)

&lt;i&gt;Background:&lt;/i&gt; It is widely accepted that risk factors for bulimia nervosa, mainly body dissatisfaction, are dependent on cultural factors. However, to date few studies have compared data from different cultures with an appropriate methodology. Therefore we aimed to gather reliable information on body dissatisfaction and other risk factors for bulimia from different nations and to reveal their functional interrelations. &lt;i&gt;Methods:&lt;/i&gt; A series of 10 silhouettes, designed to be as far as possible free from cultural and other detailed aspects, was shown to 1,751 medical and nursing students in 12 nations. A functional model was applied to each sample and tested by structural equation methodology. &lt;i&gt;Results:&lt;/i&gt; The most extreme body dissatisfaction was found in northern Mediterranean countries, followed by northern European countries. Countries currently undergoing a process of westernization show an intermediate amount of body dissatisfaction, and non-western countries demonstrate rather low values. Body dissatisfaction is the most important influence on dieting behaviour in most countries. &lt;i&gt;Conclusions:&lt;/i&gt; Despite ongoing adoption of western values worldwide, we observe remarkable differences in body dissatisfaction between different cultures. That body dissatisfaction seems disturbingly partly detached from the actual BMI, i.e. possible overweight, as well as from feelings of low self-esteem in some western countries, raises new questions about the possible origin of the pressure to be thin.
Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome
Authors: Giuseppe Pilia, Rhiannon M. Hughes-Benzie, Alex MacKenzie, Primo Baybayan, Ellson Y. Chen, Reid Huber, Giovanni Neri, Antonio Cao, Antonino Forabosco, David Schlessinger
Journal: Nature Genetics (1996)
Weight Gain From Combined Phenothiazine and Tricyclic Therapy-Reply
Authors: Stephen B. Lewis
Journal: JAMA (1978)

Dr Pfister's comments are most helpful and demonstrate the efficacy of the combination of amitriptyline and a phenothiazine in other syndromes characterized by chronic pain. We have not observed substantial weight gain in our group of diabetics; it would be interesting to compare the dosages of the drugs used in our patients with those used by Dr Pfister. However, since Dr Pfister noted weight gain only after several months of therapy, and more than half of our patients received treatment for less than six months, it is possible that weight gain is noted as a manifestation of therapy only after a lengthy treatment period. In our experience, these drugs offer prompt, dramatic relief of pain to some patients with the painful peripheral neuropathy seen in diabetes mellitus. We have found, however, that a long-term commitment to therapy is not necessary in the majority of patients since spontaneous remissions
Ototoxicity in Children With High-Risk Neuroblastoma: Prevalence, Risk Factors, and Concordance of Grading Scales—A Report From the Children's Oncology Group
Authors: Wendy Landier, Kristin Knight, F. Lennie Wong, Jin Lee, Ola Thomas, Heeyoung Kim, Susan G. Kreissman, Mary Lou Schmidt, Lu Chen, Wendy B. London, James G. Gurney, Smita Bhatia
Journal: Journal of Clinical Oncology (2014)

Platinum-based therapy is the mainstay for management of high-risk neuroblastoma. Prevalence of platinum-related ototoxicity has ranged from 13% to 95% in previous reports; variability is attributable to small samples and disparate grading scales. There is no consensus regarding optimal ototoxicity grading. Furthermore, prevalence and predictors of hearing loss in a large uniformly treated high-risk neuroblastoma population are unknown. We address these gaps in our study.Audiologic testing was completed after administration of cisplatin alone (< 400 mg/m(2); exposure one) or after cisplatin (400 mg/m(2)) plus carboplatin (1,700 mg/m(2); exposure two). Hearing loss was graded using four scales (American Speech-Language-Hearing Association; Brock; Chang; and Common Terminology Criteria for Adverse Events, version 3 [CTCAEv3]).Of 489 eligible patients, 333 had evaluable audiologic data. Median age at diagnosis was 3.3 years. Prevalence of severe hearing loss differed by scale. For those in the exposure-one group, prevalence ranged from 8% per Brock to 47% per CTCAEv3 (Brock v CTCAEv3 and Chang, P < .01; CTCAEv3 v Chang, P = .16); for those in the exposure-two group, prevalence ranged from 30% per Brock to 71% per CTCAEv3 (all pair-wise comparisons, P < .01). In patients requiring hearing aids, hearing loss was graded as severe in 49% (Brock), 91% (Chang), and 100% (CTCAEv3). Risk factors for severe hearing loss included exposure to cisplatin and carboplatin compared with cisplatin alone and hospitalization for infection.Severe hearing loss is prevalent among children with high-risk neuroblastoma. Exposure to cisplatin combined with myeloablative carboplatin significantly increases risk. The Brock scale underestimates severe hearing loss and should be used with caution in this setting.