A Clinical Study of Sjögren's Syndrome
Authors: NEAL A. VANSELOW
Journal: Annals of Internal Medicine (1963)

Article1 January 1963A Clinical Study of Sjögren's SyndromeNEAL A. VANSELOW, M.D., VERNON N. DODSON, M.D., DAVID C. ANGELL, M.D., IVAN F. DUFF, M.D., F.A.C.P.NEAL A. VANSELOW, M.D.Search for more papers by this author, VERNON N. DODSON, M.D.Search for more papers by this author, DAVID C. ANGELL, M.D.Search for more papers by this author, IVAN F. DUFF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-124 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of rheumatoid arthritis, keratoconjunctivitis sicca, and xerostomia, with or without swelling of the salivary glands, has been termed Sjögren's syndrome. Since the initial description by Henrik Sjögren in 1933 (1), clinical studies have demonstrated the not uncommon occurrence of purpura, Raynaud's phenomenon, achylia gastrica, alopecia, splenomegaly, and leukopenia, as well as dryness of the skin, nasal mucosa, and larynx in patients with this disorder. A close relationship with connective tissue diseases other than rheumatoid arthritis has been suggested by the observation that systemic lupus erythematosus (2), scleroderma (3), periarteritis nodosa (4), or polymyositis (5) may in some instances...References1. SJÖGREN H: A New Conception of Keratoconjunctivitis Sicca, Australasian Medical Publishing Company, Ltd., Sydney, 1943 (translated by Hamilton, J. B.). Google Scholar2. BAIN GO: The pathology of Mikulicz-Sjögren disease in relation to disseminated lupus erythematosus. Canad. Med. Ass. J. 82: 143, 1960. MedlineGoogle Scholar3. SHEARN MA: Sjögren's syndrome in association with scleroderma. Ann. Intern. Med. 52: 1352, 1960. 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Prepared by a committee of the American Rheumatism Association. JAMA 171: 1205, 1345, 1680, 1959. CrossrefGoogle Scholar11. MORGAN WS: The probable systemic nature of Mikulicz's disease and its relation to Sjögren's syndrome. New. Engl. J. Med. 251: 5, 1954. CrossrefMedlineGoogle Scholar12. WOLFSONCOHN WQC: Rapid Chemical Micromethods for the Analytic Fractionation of Serum Proteins, The Overbeck Company, Ann Arbor, 1951. Google Scholar13. HOWE PE: The determination of proteins in blood—a micro method. J. Biol. Chem. 49: 109, 1921. CrossrefGoogle Scholar14. A Method for Serum Proteins Using Bromphenol Blue Dye in Aqueous Solution, Technical Bulletin No. TB 6049A, Spinco Division, Beckman Instruments, Inc., Palo Alto, California, April, 1958. Google Scholar15. ZIMMERHARGRAVES FEMM: The effect of blood coagulation on L. E. cell formation. Proc. Mayo Clin. 27: 424, 1952. MedlineGoogle Scholar16. ZIFF M: A hemagglutination test for rheumatoid arthritis with enhanced sensitivity using the euglobulin fraction. Bull. Rheum. Dis. 5: 75, 1954. MedlineGoogle Scholar17. SINGERPLOTZ JMCM: The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Amer. J. Med. 21: 888, 1956. CrossrefMedlineGoogle Scholar18. THOMPSON G: Personal communication. Google Scholar19. SHORTBAUERREYNOLDS CLWWE: Rheumatoid Arthritis. A Definition of the Disease and a Clinical Description Based on a Numerical Study of 293 Patients and Controls, Harvard University Press, Cambridge, 1957. CrossrefGoogle Scholar20. WEISSMAN G: Sjögren's syndrome; review of the literature and report of a case with achalasia of the esophagus. Amer. J. Med. 24: 475, 1958. MedlineGoogle Scholar21. STOLTZEHANLONPEASEHENDERSON CADGGLJW: Keratoconjunctivitis sicca and Sjögren's syndrome. Arch. Intern. Med. 106: 513, 1960. CrossrefGoogle Scholar22. HEATON JM: Sjögren's syndrome and systemic L. E.: Brit. Med. J. 1: 466, 1959. CrossrefMedlineGoogle Scholar23. SHEARN MA: The Sjögren-Mikulicz syndrome. Calif. Med. 95: 159, 1961. MedlineGoogle Scholar24. MIKKELSENDUFFGOODSONCOULTERHERTZ WMIFLWHC: A comparative study of some recent serologic tests for rheumatoid arthritis. Ann. Intern. Med. 52: 1051, 1960. LinkGoogle Scholar25. Rheumatism and arthritis: review of American and English literature of recent years (Thirteenth Rheumatism Review). Ann. Intern. Med. 53: 38 (December 30) 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: NEAL A. VANSELOW, M.D.; VERNON N. DODSON, M.D.; DAVID C. ANGELL, M.D.; IVAN F. DUFF, M.D., F.A.C.P.Affiliations: Ann Arbor, MichiganFrom the Departments of Internal Medicine and Pathology and the Rackham Arthritis Research Unit, The University of Michigan Medical Center, Ann Arbor, Michigan.The Rackham Arthritis Research Unit is supported by a grant from the Horace H. Rackham School of Graduate Studies.Requests for reprints should be addressed to Neal A. Vanselow, M.D., Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan. 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SHEARN, M.D., F.A.C.P.Antinuclear and Precipitating Auto-antibodies in Sjogren's SyndromeThe Relation of SJögren's Syndrome to Rheumatoid Arthritis 1 January 1963Volume 58, Issue 1Page: 124-135KeywordsArthritisLupus erythematosusNasal mucosaPolymyositisProteinsRaynaud syndromeRheumatoid arthritisSalivary glandsSclerodermaSplenomegaly ePublished: 1 December 2008 Issue Published: 1 January 1963 PDF downloadLoading ...