tbuckley/cabot-search huggingface dataset:
EXPERIMENTAL OBSERVATIONS ON IRRADIATED, NORMAL, AND PARTIALLY PARATHYROIDECTOMIZED RABBITS
Authors: Frederick L. Gates, J. H. B. Grant
Journal: The Journal of Experimental Medicine (1927)

No significant differences were found in the reactions of irradiated, normal, or partially parathyroidectomized rabbits to injections of calcium chloride or disodium hydrogen phosphate. Intravenous injections of calcium chloride caused only a transient rise in blood calcium, which returned to its former level within a few hours. The upper level of blood calcium concentration is independent of parathyroid control. Subcutaneous injections of disodium hydrogen phosphate caused, in all three groups of rabbits, a similar depression of the blood calcium level. After large doses of the phosphate solution, all of the rabbits showed signs of acute tetany in which many of them died. Death or survival was not determined, apparently, by the absolute depression of blood calcium. The rabbits that died were those, in all three groups, in which a phosphorus retention carried the initial rise in serum phosphorus to even higher levels in the hours preceding death, and so changed the normal calcium-phosphorus ratio to a small fraction of its former value.
Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1
Authors: Emilios Gemenetzidis, Daniela Elena-Costea, Eric K. Parkinson, Ahmad Waseem, Hong Wan, Muy-Teck Teh
Journal: Cancer Research (2010)

Abstract Stem cells are permanent residents of tissues and thought to be targets of cancer initiation. The frequent, and often early, upregulation of the FOXM1 transcription factor in the majority of human cancers suggests that it may participate in the initiation of human tumorigenesis. However, this hypothesis has not been tested. Herein, we show that targeting the ectopic expression of FOXM1 to the highly clonogenic cells of primary human keratinocytes with stem/progenitor cell properties, but not to differentiating cells, caused clonal expansion in vitro. We show, using a functional three-dimensional organotypic epithelial tissue regeneration system, that ectopic FOXM1 expression perturbed epithelial differentiation generating a hyperproliferative phenotype reminiscent of that seen in human epithelial hyperplasia. Furthermore, transcriptional expression analysis of a panel of 28 epithelial differentiation-specific genes reveals a role for FOXM1 in the suppression of epithelial differentiation. This study provides the first evidence that FOXM1 participates in an early oncogenic pathway that predisposes cells to tumorigenesis by expanding the stem/progenitor compartment and deregulating subsequent keratinocyte terminal differentiation. This finding reveals an important window of susceptibility to oncogenic signals in epithelial stem/progenitor cells prior to differentiation, and may provide a significant benefit to the design of cancer therapeutic interventions that target oncogenesis at its earliest incipient stage. Cancer Res; 70(22); 9515–26. ©2010 AACR.
Ku80 autoantigen as a cellular coreceptor for human parvovirus B19 infection
Authors: Yasuhiko Munakata, Takako Saito-Ito, Keiko Kumura-Ishii, Jie Huang, Takao Kodera, Tomonori Ishii, Yasuhiko Hirabayashi, Yoshio Koyanagi, Takeshi Sasaki
Journal: Blood (2005)
Testing Knowledge — Scientists in Medicine — Bleak Midwinter
Authors: John Lister
Journal: New England Journal of Medicine (1969)

FORMAL examinations have played a much more prominent part in the postgraduate training of specialists in Britain than in the United States, membership of one of the Royal Colleges of Physicians being required of intending physicians and fellowship of one of the Royal Colleges of Surgeons being required of intending surgeons. In both cases the diplomas are obtained after examinations with high failure rates.The Todd report1 on medical education favors a change in emphasis in the training of specialists away from the rigid yardstick of examination results toward the American system of planned training programs for each discipline, with . . .
Abstract 5566: Phosphoproteomic profiling of Met / K-Ras signaling in colorectal cancer by label-free LTQ-Orbitrap mass spectrometry
Authors: Shawna L. Organ, Jiefei Tong, Paul Taylor, Roya Navab, Jonathan St. Germain, Michael F. Moran, Ming-Sound Tsao
Journal: Cancer Research (2010)

Abstract Background: Colorectal cancer (CRC) is the second leading cause of death from cancer overall. Mutations in the K-ras oncogene are the most frequently observed mutations in CRC. Activation of receptor tyrosine kinases, including Met, is also common in CRC. Co-activation of both Met and K-Ras could result in preferential over-activation of specific downstream cascade(s). To address the potential importance of Met and K-Ras tandem activation, we use the DLD1 CRC cell line model. DLD1 cells contain one mutated K-ras allele, resulting in a constitutively active protein. These cells express a relatively low level of Met. A derivative of this cell line, DKO4, has its mutant K-ras allele inactivated by somatic recombination. Our lab has previously shown that overexpression of Met in DLD1 cells (DLD1-Met) enhances the tumorigenicity and metastatic potential of these cells. This did not occur in DKO4-Met cells, suggesting that activated K-Ras is necessary for these Met-mediated processes. We hypothesize that Met and K-Ras co-operate to activate novel tumourigenic and metastatic signaling pathways. Methods: We undertook a label-free mass spectrometry (MS)-based proteomics examination of protein-phosphotyrosine (pY) in the DLD1 CRC model. DLD1-Met and DKO4-Met cells were enriched for pY-containing peptides and then analyzed by LC-MS/MS using an LTQ-Orbitrap mass spectrometer. Peptide quantification was achieved by using both peptide ion spectral counting and normalized extracted ion current methods. To determine ligand-dependent vs. -independent differences in Met signaling, the parental DLD1 and DKO4 cells were stimulated with an HGF time course. Previous results in the lab show that DLD1 cells with activated K-Ras have prolonged MAPK signaling in response to HGF compared to DKO4 cells. Results: 9 proteins were found to be differentially regulated in these DLD1-Met vs. DKO4-Met. Validation by Western blotting in the empty vector and Met-overexpressing lines confirmed MS findings, as well as uncovered some pY changes mediated by both Met and K-Ras. Results from temporal analyses of pY in response to HGF stimulation will be presented to address this occurrence and suggest mechanisms of Met and K-Ras dependent tumourigenesis. Conclusions: We have identified a phosphoproteomic network associated with Met/K-Ras signaling. It may include novel therapeutic targets or prognostic markers for CRC. Supported by the CIHR MOP-64345 and the CIHR Banting and Best Doctoral Research Graduate Scholarship to SO Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5566.
Bone Density and Bone Turnover Marker Monitoring After Discontinuation of Alendronate Therapy
Authors: Margaret L. Gourlay, Kristine E. Ensrud
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Clinical Lecture on Syphilitic and Cancerous Ulceration of the Tongue
Authors: C. Heath
Journal: BMJ (1881)

ULCERATION of the tongue may be simple, syphilitic, or cancerous.The simple uler is often caused by the irritation of a sharp tooth, or may be due to dyspepsia.It is small and superficial, and, unless due to local irritation, is generally multiple, and often found beneath the tongue.It is painful, and interferes with the movements of the tongue, but yields readily to treatment.The removal of the sharp corner of a decayed tooth with a file, and the subsequent application of a stick of nitrate of silver to the ulcer, are generally sufficient to effect a cure when the cause is local.WVhen it is constitutional, a brisk purge, with the local use of the glycerine of tannin or any astringent gargle, will be sufficient treatment.Syphilitic tlceratiot may appear during the secondary stage of the disorder along the edges of the tongue, and wil'l almost always be found to have a corresponding white patch on the mucous membrane of the cheek.These ulcers have no induration at their bases, but, when healed, leave an irregular fissured border, which is very characteristic.A later form of ulceration is found in fissures of the dorsum, which leave irregular furrows in healing.The deep syphilitic ulcer is due to the breaking down of a gumma, and it is this kind which is apt to be confounded with cancerous ulcera- tions.
DNA aneuploidy in ulcerative colitis
Authors: D M Melville, J M A Northover, J R Jass, N A Shepherd, J E Lennand-Jones
Journal: Gut (1987)

Administration of anti-CD25 mAb before an aggressive murine breast tumor inoculation provoked effective antitumor immunity. Compared with CD4<sup>+</sup> T cells purified from anti-CD25 mAb-pretreated mice that did not reject tumor, CD4<sup>+</sup> T cells purified from anti-CD25 mAb-pretreated mice that rejected tumor stimulated by dendritic cells (DCs) produced more IFN-γ and IL-2, and less IL-17 in vitro, and ignited protective antitumor immunity in vivo in an adoptive transfer model. Tumor Ag-loaded DCs activated naive CD8<sup>+</sup> T cells in the presence of these CD4<sup>+</sup> T cells in vitro. Tumor Ag and adoptively transferred CD4<sup>+</sup> T cells were both required for inducing a long-term tumor-specific IFN-γ-producing cellular response and potent protective antitumor activity. Although adoptively transferred CD4<sup>+</sup> T cells ignited effective tumor-specific antitumor immunity in wild-type mice, they failed to do so in endogenous NK cell-depleted, Gr-1<sup>+</sup> cell-depleted, CD40<sup>−/−</sup>, CD11c<sup>+</sup> DC-depleted, B cell<sup>−/−</sup>, CD8<sup>+</sup> T cell-depleted, or IFN-γ<sup>−/−</sup> mice. Collectively, the data suggest that adoptively transferred CD4<sup>+</sup> T cells orchestrate both endogenous innate and adaptive immunity to generate effective tumor-specific long-term protective antitumor immunity. The data also demonstrate the pivotal role of endogenous DCs in the tumor-specific protection ignited by adoptively transferred CD4<sup>+</sup> T cells. Thus, these findings highlight the importance of adoptively transferred CD4<sup>+</sup> T cells, as well as host immune components, in generating effective tumor-specific long-term antitumor activity.
A novel mutation in MPL (Y252H) results in increased thrombopoietin sensitivity in essential thrombocythemia
Authors: Michele P. Lambert, Jing Jiang, Vandana Batra, Chao Wu, Wei Tong
Journal: American Journal of Hematology (2012)

Essential thrombocythemia (ET) is a rare type of myeloproliferative neoplasm characterized by clonal expansion of the megakaryocyte and platelet lineage. Here, we describe a novel mutation (Y252H) in the thrombopoietin (TPO) receptor, or MPL, in a JAK2 mutation-negative ET patient. The bone marrow examination revealed increased numbers of dysmorphic megakaryocytes with focal clustering. The x-inactivation pattern suggested clonal expansion of hematopoietic cells in the bone marrow. Furthermore, we found that the patient's bone marrow cells were hypersensitive to TPO in generating megakaryocyte colonies in vitro. More importantly, we demonstrated that this MPL Y252H mutant confers increased TPO/MPL-mediated cell growth and increased cell survival upon cytokine withdrawal in BaF3 cells, indicating it is a disease-driving mutation and may contribute to the development of ET in vivo. In summary, this is the first report describing a mutation in the extracellular domain of MPL underlying ET.
Recent developments in Bell's palsy: Trial for Bell's palsy is in progress in Scotland
Authors: Frank Sullivan, Fergus Daly, Iain Swan
Journal: BMJ (2004)

EDITOR—Holland and Weiner's clinical review (albeit a traditional non-systematic, opinion based one) on the important topic of Bell's palsy is welcome,1 but we are concerned that their conclusions about treatment are simply not supported by current evidence.

The most recent Cochrane reviews show that no treatment has yet been shown to be more effective than placebo.2 3 The recent studies cited have not yet been included in the systematic reviews but since they are non-randomised, statements that combination therapy …
AGED GARLIC EXTRACT AND COENZYME Q10 DECREASE ARTERIAL STIFFNESS AND RETARD PROGRESSION OF CORONARY ARTERY CALCIUM IN AT-RISK FIRE FIGHTERS
Authors: Vahid Nabavi Larijani, Irfan Zed, Ferdinand Flores, Naser Ahmadi, Matthew Budoff
Journal: Journal of the American College of Cardiology (2011)
Human lgG antigranulocyte antibodies: Comparison of detection by quantitative antiglobulin consumption and by binding of <sup>125</sup>I staph protein A
Authors: Theresa Blumfelder, Gerald Logue
Journal: American Journal of Hematology (1981)

The amount of IgG in the serum of patients with suspected immune neutropenia that binds to normal paraformaldehyde-fixed human granulocytes was measured simultaneously by a quantitative antiglobulin consumption assay and by binding of 125I-staphylococcal protein A (SPA). There was a significant linear relationship between the results of these two assays for the sera of 42 different patients. However, SPA binding appeared more sensitive than the quantitative antiglobulin assay for determining IgG antigranulocyte antibodies in serum. In a patient with Felty's syndrome who underwent splenectomy, the results of both assays on sequential serum samples correlated with clinical improvement. Thus, SPA binding appears to be a sensitive and reliable technique for measuring antigranulocyte antibodies, and there is a close correlation between antibody measured by antiglobulin consumption and those detected by SPA binding.
Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers
Authors: Giovanni B Vigna, Fabrizio Costantini, Giancarlo Aldini, Marina Carini, Alberico Catapano, Fabio Schena, Arianna Tangerini, Rosanna Zanca, Egidio Bombardelli, Paolo Morazzoni, Andrea Mezzetti, Renato Fellin, Roberto Maffei Facino
Journal: Metabolism (2003)
The role of tauroursodeoxycholic acid on adipogenesis of human adipose-derived stem cells by modulation of ER stress
Authors: Byung-Hyun Cha, Jin-Su Kim, Jong Chan Ahn, Hee-Chun Kim, Byung-Soo Kim, Dong Keun Han, Sang Gyu Park, Soo-Hong Lee
Journal: Biomaterials (2014)
SOME SEVERE CASES OF TOBACCO AND QUININ AMBLYOPIA.
Authors: E. C. ELLETT
Journal: JAMA (1898)

In presenting to your notice any observations on the subject of the toxic amblyopias, the recent exhaustive works of Wood and DeSchweinitz render references to the history and literature of the subject entirely superfluous. It is from a study of the work of these gentlemen that I am enabled to appreciate the unusual features in the few cases which I wish to report, and I present them solely for the reason that they do exhibit some points a little out of the ordinary. The first case was a young man of 26, whom I saw at the request of his physician, Dr. Thomas Henderson, Feb. 28, 1894. Since August, 1893, he had not been able to see to read, though his vision began to fail some months prior to that time. Since 12 or 13 years old he has been addicted to the use, or rather the abuse, of cigarettes,
P74. A Good Manufacturing Practice procedure to generate therapeutic numbers of highly pure anti-leukaemic virus-specific T-cells
Authors: MM van Loenen, R de Boer, E van Liempt, RS Hagedoorn, P Meij, I Jedema, JHF Falkenburg, MHM Heemskerk
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Recently, we have started a clinical trial to treat patients with high risk acute leukaemia with a donor-derived HA-1-TCR transduced virus-specific T-cell product as early as 8 weeks and 14 weeks after allogeneic stem cell transplantation (allo-SCT). Donor derived Cytomegalovirus
Construction and Validation of Improved Triple Fusion Reporter Gene Vectors for Molecular Imaging of Living Subjects
Authors: Pritha Ray, Roger Tsien, Sanjiv Sam Gambhir
Journal: Cancer Research (2007)

Multimodality imaging using several reporter genes and imaging technologies has become an increasingly important tool in determining the location(s), magnitude, and time variation of reporter gene expression in small animals. We have reported construction and validation of several triple fusion genes composed of a bioluminescent, a fluorescent, and a positron emission tomography (PET) reporter gene in cell culture and in living subjects. However, the bioluminescent and fluorescent components of fusion reporter proteins encoded by these vectors possess lesser activities when compared with the bioluminescent and fluorescent components of the nonfusions. In this study, we first created a mutant (mtfl) of a thermostable firefly luciferase (tfl) bearing the peroxisome localization signal to have greater cytoplasmic localization and improved access for its substrate, d-luciferin. Comparison between the three luciferases [mtfl, tfl, and firefly luciferase (fl)] both in cell culture and in living mice revealed that mtfl possessed 6- to 10-fold (in vitro) and 2-fold (in vivo) higher activity than fl. The improved version of the triple fusion vector carrying mtfl as the bioluminescent reporter component showed significantly (P < 0.05) higher bioluminescence than the previous triple fusion vectors. Of the three different red fluorescent reporter genes (jred, hcred, and mrfp1, isolated from jellyfish chromophore, coral Heteractis crispa, and coral Discosoma, respectively) evaluated, mrfp1 was able to preserve highest expression as a component of the triple fusion reporter gene for in vivo fluorescence imaging. A truncated version of wild-type herpes simplex virus 1 (HSV1) thymidine kinase gene (wttk) retained a higher expression level than the truncated mutant HSV1-sr39 TK (ttk) as the third reporter component of this improved triple fusion vector. Multimodality imaging of tumor-bearing mice using bioluminescence and microPET showed higher luciferase activity [(2.7 +/- 0.1 versus 1.9 +/- 0.1) x (10(6) p/s/cm(2)/sr)] but similar level of fluorine-18-labeled 2'-fluoro-2'-deoxyarabinofuranosyl-5-ethyluracil (18F-FEAU) uptake (1.37 +/- 0.15 versus 1.37 +/- 0.2) percentage injected dose per gram] by mtfl-mrfp1-wttk-expressing tumors compared with the fl-mrfp1-wttk-expressing tumors. Both tumors showed 4- to 5-fold higher accumulation (P < 0.05) of 18F-FEAU than fluorine-18-labeled 9-(4-fluoro-3-hydroxymethylbutyl)guanine. This improved triple fusion reporter vector will enable high sensitivity detection of lower numbers of cells from living animals using the combined bioluminescence, fluorescence, and microPET imaging techniques.
Public health gets a makeover
Authors: A. Tonks
Journal: BMJ (2004)

Glossy magazine launched to promote healthy lifestyles 

Last week health secretary John Reid visited a north London swimming pool to launch a new glossy lifestyle magazine. Your Life! looks like the real thing. There is a soap star turned singer and a magic diet on the cover. Rock star Ms Dynamite pouts inside. And it fits in your handbag. But Your Life! is not the real thing. It is a health promotion magazine—21st century patient information about how to look after yourself, live longer, and find a smoking cessation clinic when you need one.

Your Life! is free and funded jointly by the Department of Health and 75 primary care trusts. It is produced by Dr Foster, independent publishers best known for their consumer guides to health care. All three are hoping that 24 pages of celebrities doing what they do best (talking about themselves) will reach …
TCT-372 A Novel Optical Coherence Tomography System for Lipid-rich Plaque Detection
Authors: Aiko Shimokado, Takashi Kubo, Tsuyoshi Nishiguchi, Akira Taruya, Ikuko Teraguchi, Makoto Orii, Yasutsugu Shiono, Kunihiro Shimamura, Takashi Tanimoto, Yamano Takashi, Yoshiki Matsuo, Yasushi Ino, Tomoyuki Yamaguchi, Kumiko Hirata, Atsushi Tanaka, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2014)
Effect of Dipyridamole and Aspirin on Late Vein-Graft Patency after Coronary Bypass Operations
Authors: James H. Chesebro, Valentin Fuster, Lila R. Elveback, Ian P. Clements, Hugh C. Smith, David R. Holmes, William T. Bardsley, James R. Pluth, Robert B. Wallace, Francisco J. Puga, Thomas A. Orszulak, Jeffrey M. Piehler, Gordon K. Danielson, Hartzell V. Schaff, Robert L. Frye
Journal: New England Journal of Medicine (1984)

To study the prevention of occlusion of aortocoronary-artery bypass grafts, we conducted a prospective, randomized, double-blind trial comparing long-term administration of dipyridamole (begun two days before operation) plus aspirin (begun seven hours after operation) with placebo in 407 patients. Results at one month1 showed a reduction in the rate of graft occlusion in patients receiving dipyridamole and aspirin. At vein-graft angiography performed in 343 patients (84 per cent) 11 to 18 months (median, 12 months) after operation, 11 per cent of 478 vein-graft distal anastomoses were occluded in the treated group, and 25 per cent of 486 were occluded in the placebo group. The proportion of patients with one or more distal anastomoses occluded was 22 per cent of 171 patients in the treated group and 47 per cent of 172 in the placebo group. All grafts were patent within a month of operation in 94 patients in the placebo group and 116 patients in the treated group; late development of occlusions was reduced from 27 per cent in the placebo group to 16 per cent in the treated group. The results show that dipyridamole and aspirin continue to be effective in preventing vein-graft occlusion late after operation, and we believe that such treatment should be continued for at least one year. (N Engl J Med 1984; 310:209–14.)