tbuckley/cabot-search huggingface dataset:
Early Left Ventricular Dysfunction and Chelation Therapy in Thalassemia Major
Authors: ANTHONY P. FREEMAN
Journal: Annals of Internal Medicine (1983)

Exercise radionuclide angiography was used to assess the incidence of subclinical abnormalities of left ventricular function in 23 asymptomatic patients with thalassemia major. Left ventricular ejection fraction (LVEF) at rest was normal in 18 patients and abnormal in 5. A normal LVEF response during exercise was shown in only 5 of the patients with normal resting left ventricular function. A normal response during exercise occurred more often in those patients who had received a smaller transfusional iron load and had a lower serum ferritin level (p < 0.05). Twelve of the twenty-three patients were receiving chelation therapy with subcutaneous deferoxamine. Ejection fraction at rest was normal in 11 of these patients. During exercise a normal ventricular response was shown in 4 patients. After 1 year of intensive chelation therapy in these 12 patients, left ventricular function was reassessed. A normal exercise response was seen in an additional 4 patients; 3 of these showed an increase in peak exercise LVEF, and in the remaining patient no change of peak exercise LVEF was shown. The response during exercise was unchanged in 3 patients and had deteriorated in 1 patient.
Efficient inhibition of HIV-1 replication in human immature monocyte-derived dendritic cells by purified anti–HIV-1 IgG without induction of maturation
Authors: Vincent Holl, Maryse Peressin, Sylvie Schmidt, Thomas Decoville, Susan Zolla-Pazner, Anne-Marie Aubertin, Christiane Moog
Journal: Blood (2006)
Massive Hepatic Necrosis Following Portacaval Shunt
Authors: Lynn C. Koenemann
Journal: JAMA (1966)

Complications of portacaval-shunt procedure are many and varied. In two cases of a hitherto undescribed complication, massive "anoxic pseudolobular necrosis" of the hepatic parenchyma developed immediately following side-to-side procedures. Factors other than the anastomosis (gastrointestinal bleeding and shock) were operative in one of the cases, but no explanation other than hemodynamic alterations in the liver following the shunt procedure were found in the second case. Although previously unreported, earlier stages of this complication may be the basis for many of the immediate postoperative deaths labeled "hepatic coma" or "hepatic failure" by different authors.
The Growth and Development of the Allied Health Schools
Authors: Darrel J. Mase
Journal: JAMA (1968)

With the mandate of society to extend comprehensive health care to all of our citizenry, it becomes essential to update our procedures for preparing the health manpower needed. Health is our third largest industry and shall soon become the largest. In 1900 there was one supportive person for each physician. It is estimated that today the ratio is 13 to 1. By 1975 it is expected that this ratio will be 20 or 25 to 1. These supportive personnel are most commonly referred to as those in the allied or health related professions and/or occupations. This estimate in no way implies a lessening of the current projections for more physicians and dentists. Historically many of these supportive personnel were trained in hospitals. With the extension of education beyond high school for the masses, it becomes essential to prepare those for the health professions and occupations in our junior colleges, colleges,
Smoking Cessation Reminders
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypnosis for burn patients: healing body and spirit
Authors: B. Merz
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UK government postpones publishing report on sexual health services
Authors: C. White
Journal: BMJ (2015)

Publication of a report on the effect of NHS reforms on sexual health provision in England has been postponed indefinitely despite being originally scheduled for publication in November last year.

The Department of Health review was supposed to have reported on the implementation of A Framework for Sexual Health Improvement in England ,1 which was published in March 2013 just ahead of the introduction of the Health and Social Care Act in April. The legislation made local government accountable for the bulk of services as part of its new public health remit, with the remainder split between primary care and NHS England.

When the report did not appear in November, the …
Adenosine inhibits exocytotic release of endogenous noradrenaline in rat heart: a protective mechanism in early myocardial ischemia.
Authors: G Richardt, W Waas, R Kranzhöfer, E Mayer, A Schömig
Journal: Circulation Research (1987)

The effects of exogenous and endogenous adenosine on exocytotic noradrenaline release were studied in rat hearts perfused in situ. Exocytotic release of endogenous noradrenaline (determined by high pressure liquid chromatography) was induced by electrical stimulation of the left cervicothoracic ganglion. Exogenous adenosine significantly reduced noradrenaline overflow from the heart. This suppression of noradrenaline overflow was not influenced by desipramine, indicating a mechanism independent from noradrenaline reuptake. The A1 subtype specific agonists cyclohexyladenosine and R-phenylisopropyladenosine had inhibitory effects at lower concentrations than adenosine and S-phenylisopropyladenosine, suggesting the relevance of presynaptic inhibitory adenosine receptors of the A1 subtype. Short ischemic periods of 3 minutes resulted in a marked coronary venous overflow of adenosine during reperfusion. This was accompanied by an inhibition of noradrenaline release evoked by nerve stimulation during ischemia. The adenosine antagonists theophylline and 8-phenyltheophylline prevented this suppression of noradrenaline release. Blockade of oxidative phosphorylation by cyanide in combination with glucose-free perfusion induced an increased formation of endogenous adenosine and suppression of stimulation-evoked noradrenaline overflow. Again, in the presence of the adenosine antagonists theophylline or 8-phenyltheophylline, this suppression was abolished. These results indicate that adenosine is a potent inhibitor of exocytotic noradrenaline release in the heart with relevance during conditions of increased endogenous adenosine formation such as myocardial ischemia.
Higher influenza-related paediatric admission rates in the tropics than in temperate regions
Authors: D D Creer
Journal: Thorax (2003)

▴ Chiu S S, Lung Lau Y, Chan K H, et al . Influenza-related hospitalisations among children in Hong Kong. N Engl J Med2002;347:2097–103 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] This retrospective population based study calculated the rate of excess hospital admissions due to influenza in children aged 15 or under with acute respiratory disease. The data were collected from the Hospital Authority of the Hong Kong Special Administrative Region, China. The excess admissions … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DChiu%26rft.auinit1%253DS.%2BS.%26rft.volume%253D347%26rft.issue%253D26%26rft.spage%253D2097%26rft.epage%253D2103%26rft.atitle%253DInfluenza-Related%2BHospitalizations%2Bamong%2BChildren%2Bin%2BHong%2BKong%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa020546%26rft_id%253Dinfo%253Apmid%252F12501221%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa020546&link_type=DOI [3]: /lookup/external-ref?access_num=12501221&link_type=MED&atom=%2Fthoraxjnl%2F58%2F3%2F251.atom [4]: /lookup/external-ref?access_num=000180040900002&link_type=ISI
Petition Targets Painkiller Marketing in Effort to Curb Overdose Deaths
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcium Supplementation with and without Hormone Replacement Therapy To Prevent Postmenopausal Bone Loss
Authors: John F. Aloia
Journal: Annals of Internal Medicine (1994)

To determine whether augmentation of dietary calcium is effective in the prevention of early postmenopausal bone loss.Three-arm, placebo-controlled, randomized parallel trial. The study duration was 2.9 +/- 1.1 (SD) years.General community.118 healthy, white women 3 to 6 years after spontaneous menopause, recruited by community announcement.Random allocation to daily intake of 1700 mg of calcium (calcium carbonate given in divided doses with meals); placebo; or conjugated equine estrogens (0.625 mg; days 1 to 25), progesterone (10 mg; days 16 to 25), and 1700 mg of elemental calcium daily. Each participant received 400 IU of vitamin D daily.Total body calcium measured by delayed gamma neutron activation analysis and whole-body counting; bone mineral density of the spine, femur, and radius measured by photon absorptiometry.Bone mineral density declined in the placebo group for the lumbar spine (-2.1%/y; 95% Cl, -3.3 to -0.9), femoral neck (-2.0%/y; Cl, -2.6 to -1.2), trochanter (-1.6%/y; Cl, -2.4 to -0.8), Ward triangle (-2.7%/y; Cl, -3.7 to -1.7), and total body calcium (-2.0%/y; Cl, -2.2 to -1.8). Rates of change were intermediate for calcium augmentation compared with placebo and estrogen-progesterone-calcium but statistically significant compared with placebo for total body calcium (-0.5%/y; Cl, -0.9 to -0.1; P = 0.006) and the femoral neck (-0.8%/y; Cl, -1.4 to -0.2; P = 0.03).Although less effective than estrogen-progesterone-calcium, calcium augmentation alone significantly retards bone loss from the femoral neck and improves calcium balance in recently postmenopausal women. Dietary calcium augmentation should be recommended as a strategic option in helping to prevent early postmenopausal bone loss.
Quantification of function in normal and infarcted regions of the left ventricle
Authors: J. HEIKKILA, B. S. TABAKIN, P. C. HUCENHOLTZ
Journal: Cardiovascular Research (1972)

The extent to which non-functioning or infarcted myocardial segments impose a detrimental load on left ventricular performance is not easily measured and its significance may be underestimated. A method for quantifying contractility in multiple segments of the left ventricle and for assessing the role of the resulting ventricular asynergy was investigated in 15 open-chested pigs with experimental myocardial infarction. High-speed cineradiography of metal clips and cineventriculography showed normal systolic epicardial shortening and transmural wall thickening to an average 15·8% and 31·7% respectively from their end-diastolic values. An unexpected degree of thickening of the left ventricular wall (31·2% of total systolic thickening) was observed in the isovolumic phase. Isoproterenol enhanced contraction mechanics markedly, again mostly during the isovolumic phase. The changes in epicardial segment length and wall thickness completely separated transmural infarction areas from adjacent or remote regions with normal muscle function (P<0·001). Ventricular asynergy occurred, and often reached its maximum extent, in the isovolumic phase. Force-velocity analysis of muscle function also confirmed significant deterioration of total ventricular function. Increased end-diastolic segment length in association with normal rate of contraction in the uninvolved muscle areas indicated compensating mechanism of the Frank-Starling type to occur immediately after acute infarction. The clinical implications of the measurement of wall thickness changes during systole for the assessment of left ventricular function are discussed.
IMMUNOLOGICAL AND CHEMICAL INVESTIGATIONS OF VACCINE VIRUS
Authors: Robert F. Parker, Thomas M. Rivers
Journal: The Journal of Experimental Medicine (1936)

Humoral antibodies and a certain degree of resistance to infection with vaccinia, probably not enduring, are produced in rabbits by the repeated injections of inactive formolized (0.3 per cent) elementary bodies of vaccinia and virus-free filtrates of dermal vaccine virus. Single injections of large amounts of elementary bodies are not as effective as similar amounts administered in small repeated doses. Drastic treatment (10 per cent formaldehyde or boiling for 2 hours) almost completely alters or destroys the antigenicity of elementary bodies. It appears that the production of precipitins and agglutinins does not parallel that of neutralizing antibodies and that the mere presence of such antibodies in the serum of a rabbit as the result of injections of inactive elementary bodies does not necessarily indicate that the animal possesses a great degree of resistance to infection with a potent vaccine virus. The fact that some neutralizing antibodies appeared in the sera of rabbits that had received injections of inactive elementary bodies can be interpreted as indicating that at least not all neutralizing antibodies for vaccine virus are the result of a reaction to an antigen produced by the host in consequence of a vaccinal infection. No evidence was obtained to show that elementary bodies inactivated by our methods (0.3 per cent formaldehyde) would serve as a suitable vaccine for the protection of human beings against smallpox.
Blood Fibrinolytic Activity in Man
Authors: DOUGLAS R. ROSING, PIETER BRAKMAN, DAVID R. REDWOOD, ROBERT E. GOLDSTEIN, G. DAVID BEISER, TAGE ASTRUP, STEPHEN E. EPSTEIN
Journal: Circulation Research (1970)

This investigation was undertaken in normal subjects to define the relationship between the intensity of exercise and magnitude of fibrinolytic response and to examine the effect of diurnal variations on the exercise response. Fibrinolytic activity was measured on fibrin plates and expressed as mm 2 . Diurnal variations occurred with lowest activity at 8:00 AM (mean, 66 mm 2 ), and peak activity between 5:00 and 8:00 PM (mean, 266 mm 2 , P &lt;0.001). Five minutes of maximal treadmill exercise caused a marked increase in mean activity from 90 to 658 mm 2 ( P &lt;0.001). Five minutes of 70% maximal exercise produced no significant increase, but 30 minutes increased activity to 626 mm 2 ( P &lt;0.005). In contrast, 30 minutes of 40% maximal exercise produced a small elevation from 80 to 173 mm 2 ( P &lt;0.005). Maximal and 40% maximal exercise evoked greater responses at 4:00 PM than 8:00 AM . Exercise produces increases in fibrinolytic activity which are related to the relative intensity of exercise, its duration, and the time of day it is performed. Short bursts of intense exercise cause marked increases, but more prolonged bouts of moderate exercise are required to produce similar increases. The increases with prolonged mild exercise are small and comparable to those observed during resting diurnal variations.
Evaluation of the OSM2 Hemoximeter
Authors: R. J. McKINNEY, E. A. HARRIS
Journal: Cardiovascular Research (1978)

The linearity and repeatability of measurements of total haemoglobin concentration ([Hb]) and oxygen saturation (So2) by the OSM2 oximeter have been studied. Standard deviations (SD) of measurements from linearity were as follows: [Hb], 4.2 g . litre-1; So2, 1.14 to 1.08% between zero and 100% saturation. Reproducibility by a single operator was within SD 1.1 g . litre-1 for [Hb] and 0.32% for So2, and between operators the means of 5 measurements had SD 0.42 g . litre-1 for [Hb] and 0.19% for So2, suggesting little if any extra variation from one operator to another. Foetal haemoglobin behaved as adult haemoglobin, but carboxyhaemoglobin caused a systematic and reproducible error in So2 measurement, from which HbCO concentration can be derived.
Treatment of common and plantar viral warts with human lymphoblastoid interferon-α—pilot studies with intralesional, intramuscular and dermojet injections
Authors: J.R. GIBSON, S.G. HARVEY, D. KEMMETT, J. SALISBURY, P. MARKS
Journal: British Journal of Dermatology (1986)

Pilot studies with human lymphoblastoid interferon-alpha(Wellferon), utilizing the intralesional, intramuscular and dermojet routes, have been performed in 39 patients with common and plantar viral warts resistant to conventional therapy. Clinical efficacy, local and systemic toxicity, and effects on haematological and clinical chemistry parameters has been measured. Our results indicate that the intralesional route is the most favourable as it combines an acceptable therapeutic ratio with a procedure that may be performed quickly and with no prior preparation of the lesion.
Endoscopic Ultrasonographic Study of the Azygos Vein Before and After Endoscopic Obliteration of Esophagogastric Varices by Injection Sclerotherapy
Authors: M. A. Kassem, A. Z. Salama, S. M. Zakaria, None Hassaballah, S. M. Hunter
Journal: Endoscopy (2000)

Background and Study Aims: The azygos vein plays an important role as a drainage system for the superior portosystemic collateral circulation in portal hypertensive patients. Endoscopic ultrasonography (EUS) and Doppler EUS allow the performance of hemodynamic studies of the azygos vein. In this study, we observed the changes in the azygos vein which occur with variceal obliteration by endoscopic injection sclerotherapy (EIS).
UNILOCULAR OVARIAN CYST, WEIGHING NINETY-FIVE POUNDS, SUCCESSFULLY REMOVED.
Authors: GEO. E. RANNEY
Journal: JAMA (1884)

The following case is one of interest for a number of reasons, and especially so on account of the size of the tumor, which, as far as I know, is the largest of the kind ever removed, while few tumors of any variety have exceeded it in weight. A case (occurring in a negro woman) of fibro-cyst of the uterus, weighing 130 pounds, including seventy-one pounds of fluid drawn from the cyst, six days before the death of the patient, together with the solid portion of the tumor, and twenty-four pounds of fluid removed after death, is reported by Dr. C. C. Stockard, of Miss., in the New York<i>Med. Record</i>, Aug. 16, 1884, concerning which he says it is, as far as he can learn, the largest one on record. In this case the question may arise as to whether the most of the twenty-four pounds removed on post-mortem
Risk identification and interventions to prevent type 2 diabetes in adults at high risk: summary of NICE guidance
Authors: H. Chatterton, T. Younger, A. Fischer, K. Khunti
Journal: BMJ (2012)

Almost three million people in the United Kingdom have diabetes and 850 000 people may be undiagnosed. It has been estimated that five million people will have diabetes by 2025. About 90% of them will have type 2 diabetes.1 About 15% (one in seven) of adults have impaired glucose regulation,2 and an estimated 5-12% of these people develop type 2 diabetes each year.1 People with impaired glucose regulation are 5-15 times more likely to develop type 2 diabetes than those with normal glucose values.3 Successful prevention requires population based action for the whole community,4 together with interventions targeted at those at greatest risk. This article summarises the recommendations from the National Institute for Health and Clinical Excellence (NICE) on the identification and management of type 2 diabetes in people aged 18 or more who are at high risk.5 NICE recommendations are based on systematic reviews of best available evidence and explicit consideration of cost effectiveness. When limited evidence is available, recommendations are based on expert testimony and the Programme Development Group’s experience and opinion of what constitutes good practice. Evidence levels for the recommendations are given in italic in square brackets. ### Risk identification: stage 1