tbuckley/cabot-search huggingface dataset:
18F-FDG PET/CT in an Unusual Case of Cardiac Plexiform Neurofibromatosis
Authors: Maria Mathew D’souza, Puneet Sondhi, Paschal D’souza, Rajnish Sharma, Abhinav Jaimini, Santosh Pandey, Anupam Mondal, Rajendra Prashad Tripathi
Journal: Clinical Nuclear Medicine (2015)

Cardiac involvement is rare in neurofibromatosis 1 (NF 1). Very few cases of cardiac masses in this entity have been documented in the world literature. We present the F-FDG PET/CT findings in a rare case of cardiac plexiform neurofibromatosis.
THE IATROMETEOROLOGY OF HIPPOCRATES
Authors: A. Haviland
Journal: BMJ (1854)

Amr hou, prscbed to the lnguid lady; but a large mount of anatomial knowledge, of m anical dexterity, et pactical acquaintance with surgy, and of knowledge of its great rules, are essential; and therefore we maintai that, on the eve of a war, the thirty-five appointments made within the last few weeks, should have been prizes worthy of the elik of our hospitals and dissecting rooms.'The East India Company could at once secure such select surgical officers; and why should our glorious British Navy have to put up with those who can get no other employment?Notwithstanding this Parliamentary defeat, let each of us keep the subject before the public, and bring it privately before every member of both Houses with whom he may come in contact; for who among them are not per-.onallyinterested in the efficiency of the naval medical service?Who among them, in a few weeks, or even at the present moment, may not have sons, or brothers, or connexions, exposed to the most appaIlipg injuries, requiring the highest skill?The degradation of the naval medical service is, in fact, exposing to bad surgery not only the finest fellows in the world-the body of sailors-but likewise the officers, among whom are the glite of our aristocracy. ASSOCIATrON INTELLIGENCE.MEDIC.AL BENEVOLENT FUND.At the last meeting of the Committee, the health of Mr.Newnlham not permitting him to continue the arduous duties -of Honorar Secretary to the Funid, in addition to those of Treasnrer, Dr. James Bright, haing offered to uindertake the -office of Honorary Secretary, was unanimously appointed.Mlr.Toynbee still retains the office of HIonorary
297Osteoglycin regulates cardiac fibrosis in the pressure-overloaded heart
Authors: S Deckx, L Van Aelst, P Carai, A Papageorgiou, S Heymans
Journal: Cardiovascular Research (2014)

Hypertension and/or aging impose stress on the heart with consecutive cardiac hypertrophy, inflammation and fibrosis, processes that lead to heart failure. Our group has previously shown that non-structural matrix proteins such as TSP-2 and SPARC are critical during hypertension, fibrosis, and age-related cardiac dysfunction. Osteoglycin (OGN) is a class III member of the small leucine rich proteoglycans, and was recently identified as a marker of increased left ventricular mass in a study using genomics in recombinant inbred hypertensive rat strains. Its precise biological role in cardiac remodeling, however, remains unclear. We hypothesize that OGN will influence cardiac hypertrophy and fibrosis and hence is critical in the cardiac response during hypertension and aging. We show in young adult mice (3 months old) that hypertension-induced pressure overload of the heart causes two phases of cardiac fibrosis, following 28 days of angiotensin-II (AngII) infusion. The first phase develops between days 3 to 7 after the AngII-treatment and consists of diffuse interstitially deposited loose fibers. During the second wave of fibrosis, which starts at 14 days, these loose fibers transition into more localized scars of denser collagens. Interestingly, the expression of OGN mRNA also shows a biphasic response, significantly decreasing prior to each phase of fibrosis, at day 1 (96% decrease, p=0.002) and day 14 (84% decrease, p=0.004) respectively. Moreover, hypertension causes exaggerated cardiac fibrosis (7.54±1.58 vs. 3.65±0.62 %, p=0.04) and increased heart weight to body weight ratios (6.39±0.31 vs. 5.42±0.17 mg/g, p=0.01) in young adult OGN null mice when compared to WT littermates, but no differences in the amount of infiltrating leukocytes (31.48±9.82 vs. 36.32±18.75 cells/mm2), after 28 days of AngII infusion. In addition, aging results in decreased cardiac function, as measured by ejection fraction, in 18 months versus 3 months old OGN null mice (42.65±2.74 vs. 58.05±1.37 %, p=0.0001), which is absent in WT mice (51.01±3.11 vs. 53.01±1.67 %, p=0.62). Furthermore, a follow-up study in WT and OGN null mice showed a decrease in stroke volume over time in the OGN null mice (39.30±2.90 μl at 6 months, 35.54±1.95 μl at 12 months and 31.13±1.29 μl at 18 months, p=0.04 between 6 and 18 months) but not in the WT mice (41.61±2.02 μl at 6 months, 39.04±1.95 μl at 12 months and 41.04±3.05 μl at 18 months). Collectively, these data suggest that OGN regulates cardiac fibrosis during pressure overload and is therefore important in the remodeling response to hypertension and aging.
Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN)
Authors: Antonio Palumbo, Sara Bringhen, Heinz Ludwig, Meletios A. Dimopoulos, Joan Bladé, Maria V. Mateos, Laura Rosiñol, Mario Boccadoro, Michele Cavo, Henk Lokhorst, Sonja Zweegman, Evangelos Terpos, Faith Davies, Christoph Driessen, Peter Gimsing, Martin Gramatzki, Roman Hàjek, Hans E. Johnsen, Fernando Leal Da Costa, Orhan Sezer, Andrew Spencer, Meral Beksac, Gareth Morgan, Hermann Einsele, Jesus F. San Miguel, Pieter Sonneveld
Journal: Blood (2011)
948-46 Preserved Cardiac Baroreflex Control of Renal Cortical Blood Flow in Advanced Heart Failure Patients: A Positron Emission Tomography Study
Authors: Holly R. Middlekauff, Egbert U. Nitzsche, Michele A. Hamilton, Heinrich R. Schelbert, Gregg C. Fonarow, Jaime D. Moriguchi, Antoine Hage, Saleh Saleh, G. Gary Gibbs
Journal: Journal of the American College of Cardiology (1995)
Preventive Medicine
Authors: Harold J. Magnuson
Journal: JAMA (1966)

The Section on Preventive Medicine is the American Medical Association's home of those special interests in medicine that have been identified under the American Board of Preventive Medicine —currently public health, aerospace medicine, occupational medicine, and general preventive medicine. Discontent with the term "preventive medicine," with the specialty groupings under preventive medicine, and with the emphasis of various residency programs is frequently expressed. Is this discontent purely one of semantics or are there differences in goals and purposes that preclude a unified approach? If we could agree on goals and purposes, are the means of attaining these goals so diverse that the means themselves determine widely different professional capabilities? These are issues which can be reviewed superficially at best in the space allotted. I believe examination of the major components will identify more that unite than divide us and that the jobs to be done in the years ahead call
Early Diagnosis and Treatment of Endocrine Disorders
Authors: Richard J. Comi
Journal: Annals of Internal Medicine (2003)

Medical Writings: Book Notes19 August 2003Early Diagnosis and Treatment of Endocrine DisordersRichard J. Comi, MDRichard J. Comi, MDDartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-4-200308190-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Bar RS, ed. 369 pages. Totowa, NJ: Humana Pr; 2003. $135.00. ISBN 1588291936. Order phone 973-256-1699.Field of medicine: Adult endocrinology.Format: Hardcover, multiauthored book.Audience: Medical students, housestaff, primary care physicians, and endocrinologists.Purpose: To provide the basis for early recognition and treatment of endocrine disorders.Content: This book has 18 chapters, organized by topics, not symptoms. Each chapter is authored by an expert or experts in the field. The topics emphasize straightforward major hormonal disorders that would be considered or cared for in an internal medicine practice. The book contains many tables, relatively few figures, and extensive bibliographies. ... Author, Article, and Disclosure InformationAffiliations: Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 August 2003Volume 139, Issue 4Page: 312KeywordsEndocrinologyEpidemiologyGlucose intolerancePrevention, policy, and public healthPrimary care physiciansSoftware tools ePublished: 19 August 2003 Issue Published: 19 August 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Somalia: Medicine and the Military
Authors: Michael J. VanRooyen
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Despite being out of the international spotlight, the civil war in Somalia continues to destroy the socioeconomic structure of the country. Warring factions have displayed persistent aggression against relief workers and have forced many organizations providing humanitarian assistance to leave the country. While US military personnel treated many Somali patients,<sup>1</sup>we propose that the most significant medical contribution by military forces was the provision of security measures. This enabled nongovernment organizations to provide humanitarian aid and played a vital role in the delivery of medical assistance. We worked as members of a mobile medical team in urban and rural Somalia with Samaritan's Purse/World Medical Missions, an international medical relief organization. The clinics, staffed by four physicians and six nurses, treated 44563 patients in an 11-month period. Security issues were a major concern, and mobile clinics were designed to avoid the problems associated with permanent medical facilities,
The Bard in His Outcast State
Authors: Steve Schlozman
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-Dose Corticosteroids for Septic Shock
Authors: Edward H. Kass
Journal: New England Journal of Medicine (1984)

No aspect of clinical medicine is more dramatic than the presentation of severe infection with vasomotor collapse, and none more difficult to evaluate and to treat successfully. Every clinician has seen patients with high fever, coma, and undetectable blood pressure, has given the inevitable hopeless prognosis, and yet has seen some patients recover after antimicrobial treatment. Antimicrobial drugs, when first introduced, deserved to be called "miracle drugs." Unhappily, in severe sepsis, such miracles have been sporadic and unpredictable, and the search goes on for a better understanding and treatment of the complex events that occur in severe infection.When adrenal . . .
Evaluation and the Recent Medical Graduate
Authors: Richard L. Egan
Journal: JAMA (1982)

Current efforts to improve the methods of evaluating the knowledge and ability of recent medical graduates have served to emphasize the complexity and difficulty of the task, because the process requires several distinct methods and involves several groups. For the recent medical graduate, two evaluation procedures are critical: one determines the eligibility for appointment to an accredited residency, and the other determines the issuance of a license to practice medicine. The bottom line: Is this graduate knowledgeable, skilled, and competent to care for the patient? There are qualifiers, required by both evaluation procedures, that are intended to provide the measure of assurance. Both are concerned with documented, educational preparation and the evaluation of the ability of the individual. Both evaluation procedures require satisfactory completion of an acceptable program of medical education leading to the degree, doctor of medicine, or its equivalent. Graduation from a medical school accredited by the Liaison
Antibacterial Agents: Enzyme‐Coated Mesoporous Silica Nanoparticles as Efficient Antibacterial Agents In Vivo (Adv. Healthcare Mater. 10/2013)
Authors: Li‐li Li, Hao Wang
Journal: Advanced Healthcare Materials (2013)

On page 1351, Li-li Li and Hao Wang report lysozyme-coated mesoporous silica nanoparticles as anti-bacterial agents that exhibit efficient antibacterial activity both in vitro and in vivo with low cytotoxicity and negligible hemolytic side effect. The lysozyme corona provides multivalent interaction between nanoparticles and bacterial walls, promoting hydrolysis of peptidoglycans and increased membrane-perturbation abilities. The survival bacteria in colon are three orders of magnitude lower than that in the untreated group.
Acute Nonlymphocytic Leukemia
Authors: RONALD R. REIMER
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 June 1979Acute Nonlymphocytic LeukemiaRONALD R. REIMER, M.D., CARL W. GROPPE JR., M.D.RONALD R. REIMER, M.D.Search for more papers by this author, CARL W. GROPPE JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-989_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although acute leukemia is a potential long-term complication of alkylating agent therapy (1), interactions between these drugs and radiation therapy or radiomimetic drugs are poorly understood. Doxorubicin (adriamycin) is a radiomimetic drug carcinogenic to laboratory animals (2). It is frequently used in conjunction with cyclophosphamide and radiation therapy for various solid tumors. We have recently evaluated a patient who developed acute leukemia after such combined modality therapy.A 56-year-old white woman received preoperative pelvic radiation (5000 rad) in February 1976 for an adenosquamous carcinoma of the endometrium. At surgery, her uterus and both ovaries contained tumor, and...References1. REIMERHOOVERFRAUMENIYOUNG RRJR: Acute leukemia after alkylating-agent therapy of ovarian cancer. N Eng J Med 297:177-181, 1977 CrossrefMedlineGoogle Scholar2. MARQUARDTPHILIPSSTERNBERG HFS: Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin. Cancer Res 36:2065-2069, 1976 MedlineGoogle Scholar3. GRECOBRERETONKENTZIMBLERMERRILLJOHNSON FHHHJR: Adriamycin and enhanced radiation reaction in normal esophagus and skin. Ann Intern Med 85:294-298, 1976 LinkGoogle Scholar4. MINOWBENJAMINGOTTLIEB RRJ: Adriamycin cardiomyopathy —an overview with determination of risk factors. Cancer Chemother Rep 6:195-201, 1975 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland Clinic Foundation Cleveland, OH 44106 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySecond malignancies and Hodgkin's disease — The Royal Marsden Hospital experienceCytotoxic Drugs and LeukaemogenesisAcute myeloblastic leukemia following treatment for non-hematopoietic cancers: Report of 19 cases and review of the literature 1 June 1979Volume 90, Issue 6Page: 989-989KeywordsAcute myeloid leukemiaDrug interactionsDrug therapyDrugsEndometriumOvariesRadiation therapyResearch laboratoriesSurgeryUterus Issue Published: 1 June 1979 PDF downloadLoading ...
Abstract B51: Ligand-independent EphA2 signaling through Akt is preferentially activated in prostate cancer bone metastases and is important for tumor growth
Authors: Aaron Petty, Hui Miao, Hong Guo, Colm Morrissey, Arul Chinnaiyan, Hong Wu, Bingcheng Wang
Journal: Cancer Research (2012)

Abstract Prostate cancer progression to castration-resistance (CRPC) and metastasis represent the major challenges to effective prostate cancer therapy. PI3 kinase/Akt pathway activation has been linked to CRPC progression and metastasis, but the precise mechanisms have only been partially determined. Recently, we discovered that ligand-independent activation of the EphA2 receptor tyrosine kinase by Akt on a serine 897 site (S897) promotes cell migration and invasion, while stimulation with its ligand, ephrin-A1, downregulates EphA2 and inhibits migration and invasion. In the current study, we sought to determine whether ligand-independent EphA2 activation by Akt is linked to prostate cancer metastasis and progression to CRPC through biochemical and immunohistochemical analyses. Analysis of a panel of human prostate cancer tissues revealed EphA2 overexpression and increased S897 phosphorylation primarily in bone metastases, the primary metastatic site. Similarly, EphA2 was overexpressed in human cell lines from bone and brain metastases, but not in those from lymph node metastasis or primary tumor. Further analysis in a PTEN-deletion mouse model of aggressive prostate cancer revealed increased S897 phosphorylation in prostate glands from PTEN-null mice, compared to wild type prostate glands. To determine the potential link of EphA2 phosphorylation to CRPC progression, we compared S897 phosphorylation in xenograft tumors from both LAPC9 androgen-dependent and castration-resistant prostate cancer cell lines and found increased S897 phosphorylation in tumors from castration-resistant cells. Finally, abolishing S897 phosphorylation through the S897A point mutation inhibited growth of PC3 prostate cancer cells in a xenograft mouse model. Our study supports a link between ligand-independent EphA2 activation and prostate cancer progression and metastasis to bone, as well as primary tumor growth, highlighting a potential new mechanism involved in malignant prostate cancer progression. Citation Format: Aaron Petty, Hui Miao, Hong Guo, Colm Morrissey, Arul Chinnaiyan, Hong Wu, Bingcheng Wang. Ligand-independent EphA2 signaling through Akt is preferentially activated in prostate cancer bone metastases and is important for tumor growth [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr B51.
CONTAMINATION OF BARIUM ENEMA APPARATUS DURING ITS USE
Authors: Phillip H. Meyers
Journal: JAMA (1960)

An analysis of methods in which barium enemas are performed in some departments of radiology will usually show that complete asepsis is lacking. In most, the enema tip is disposable, but the enema set (can, all tubing, glass connecting rods, and tips) is autoclaved or disposed of after each examination in very few, if any, departments. Recently M. H. Nathan<sup>1</sup>demonstrated sudden rapid increases in rectal pressure, which he interpreted as mass peristalsis. He observed that pressures above 75 cm. H<sub>2</sub>O (55.5 mm. Hg) resulted in backflow of fecal matter into the enema container which was suspended at a height of 2.5 ft. above the table; this occurred in 12 of 14 patients who exhibited mass peristalsis. It is the purpose of this paper to demonstrate the pressure changes during barium enema examination which may result in contamination of the apparatus and to prevent possible contamination by
Hepatitis B Virus Vaccine
Authors: John D. Hamilton
Journal: JAMA (1983)

At the Duke University Medical Center, Durham, NC, there are approximately ten recognized hepatitis B virus (HBV) infections per year in employees. The hospital's hepatitis control program costs $91,995 per year, including costs for workman's compensation, hyperimmune globulin, laboratory tests, lost revenue, liability, personnel, and medical treatment. A program to immunize high-risk medical center personnel and to accommodate residual HBV problems in nonimmunized employees would cost $206,304 in the first year. By seven years the cumulative costs of an immunization program would equal those without a program and at ten years would be cost saving ($746,742 with program<i>v</i>$919,950 without a program). Given certain assumptions, HBV vaccine is a cost-beneficial alternative for a major employee health hazard. (<i>JAMA</i>1983;250:2145-2150)
Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut
Authors: Nancy M. Joseph, Shenghui He, Elsa Quintana, Yun-Gi Kim, Gabriel Núñez, Sean J. Morrison
Journal: Journal of Clinical Investigation (2011)

It is unclear whether neurogenesis occurs in the adult mammalian enteric nervous system (ENS). Neural crest-derived cells capable of forming multilineage colonies in culture, and neurons and glia upon transplantation into chick embryos, persist throughout adult life in the mammalian ENS. In this study we sought to determine the physiological function of these cells. We discovered that these cells could be identified based on CD49b expression and that they had characteristics of enteric glia, including p75, GFAP, S100B, and SOX10 expression. To test whether new neurons or glia arise in the adult gut under physiological conditions, we marked dividing progenitors with a thymidine analog in rodents under steady-state conditions, or during aging, pregnancy, dietary changes, hyperglycemia, or exercise. We also tested gut injuries including inflammation, irradiation, benzalkonium chloride treatment, partial gut stenosis, and glial ablation. We readily observed neurogenesis in a neurogenic region of the central nervous system, but not reproducibly in the adult ENS. Lineage tracing of glial cells with GFAP-Cre and GFAP-CreERT2 also detected little or no adult ENS neurogenesis. Neurogenesis in the adult gut is therefore very limited under the conditions we studied. In contrast, ENS gliogenesis was readily observed under steady-state conditions and after injury. Adult enteric glia thus have the potential to form neurons and glia in culture but are fated to form mainly glia under physiological conditions and after the injuries we studied.
Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL
Authors: Yongzhi Cui, Masahiro Onozawa, Haven R. Garber, Leigh Samsel, Ziyao Wang, J. Philip McCoy, Sandra Burkett, Xiaolin Wu, Peter D. Aplan, Crystal L. Mackall
Journal: Blood (2015)