The Implications of HL-A W27
Authors: FRANK C. ARNETT
Journal: Annals of Internal Medicine (1976)

Editorials1 January 1976The Implications of HL-A W27FRANK C. ARNETT JR., M.D.FRANK C. ARNETT JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-1-94 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe paper by Cohen and colleagues in this issue of the Annals brings into sharp focus the importance of the association of the histocompatibility antigen, HL-A W27, with the spondylitic group of diseases. Their data show that the prevalence of spondylitis may far exceed the 0.4% previously estimated and may actually approach 1% to 2%, a figure comparable to that for rheumatoid arthritis (1). Another recent study supports this same high frequency of "spondylitis stigmata" in "apparently healthy" W27-positive male blood donors but additionally reports a similar risk for women (2). From these studies it would appear that spondylitis has...References1. NUKIBROOKSBUCHANAN GRW: The economics of arthritis. Bull Rheum Dis 23:726-733, 1972 MedlineGoogle Scholar2. CALINFRIES AJ: Striking prevalence of ankylosing spondilitis in "healthy" W27 positive males and females. N Engl J Med 293:835-839, 1975 CrossrefMedlineGoogle Scholar3. CEPPELLINIVANROOD RJ: The HL-A system. I. Genetics and molecular biology. Semin Hematol 11:233-251, 1974 MedlineGoogle Scholar4. SCHLOSSTEINTERASAKIBLUESTONE LPR: High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med 288:704-706, 1973 CrossrefMedlineGoogle Scholar5. BREWERTONHARTNICHOLLS DFA: Ankylosing spondylitis and HL-A 27. Lancet 1:904-907, 1973 CrossrefMedlineGoogle Scholar6. MORRISMETZGERBLUESTONE RAR: HL-A W27—a clue to the diagnosis and pathogenesis of Reiter's syndrome. N Engl J Med 290:554-556, 1974 CrossrefMedlineGoogle Scholar7. MCCLUSKEYLORDONARNETT ORF: HL-A 27 in Reiter's syndrome and psoriatic arthritis: a genetic factor in disease susceptibility and expression. J Rheum 1:263-268, 1974 Google Scholar8. METZGERMORRISBLUESTONE ARR: HL-A W27 in psoriatic arthropathy. Arthritis Rheum 18:111-115, 1975 CrossrefMedlineGoogle Scholar9. MORRISMETZGERBLUESTONE RAR: HL-A W27—a useful discriminator in the arthropathies of inflammatory bowel disease. N Engl J Med 290:1117-1119, 1974 CrossrefMedlineGoogle Scholar10. AHOAHVONENLASSUS KPA: HL-A 27 in reactive arthritis: a study of Yersinia arthritis and Reiter's disease. Arthritis Rheum 17:521-526, 1974 CrossrefMedlineGoogle Scholar11. BREWERTONNICHOLLSCAFFREY DAM: Acute anterior uveitis and HL-A 27. Lancet 2:994-996, 1973 CrossrefGoogle Scholar12. RACHELEFSKYTERASAKIKATZ GPR: Increased prevalence of W27 in juvenile rheumatoid arthritis. N Engl J Med 290:892-893, 1974 CrossrefMedlineGoogle Scholar13. MCDEVITTBODMER HW: Histocompatibility antigens, immune responsiveness and susceptibility to disease. Am J Med 52:1-8, 1972 CrossrefMedlineGoogle Scholar14. DICKSTURROCKGOEL HRG: The association between HL-A antigens, ankylosing spondylitis and sacroiliitis. Tissue Antigens 5:26-32, 1975 CrossrefMedlineGoogle Scholar15. VAN DER LINDENKEUNINGWUISMAN JJJ: HL-A 27 and ankylosing spondylitis. Lancet 1:520-521, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Medicine The Johns Hopkins University Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe BackHLA loss variants of a B27+ lymphoblastoid cell line: Genetic and cellular characterizationIn vitro t lymphocyte proliferative response toyersinia enterocolitica in reiter's syndromeFollowup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27Immunology of renal transplantationA Logical Approach to ArthritisThe role of HLA B27 in the diagnosis and management of low-back pain and sciaticaAnkylosing Spondylitis: Recent Advances in Diagnosis and TreatmentHLA-B27 AND MODIFIED BONE FORMATIONLOW INCIDENCE OF HLA-B27 IN AMERICAN BLACKS WITH SPONDYLOARTHROPATHIES 1 January 1976Volume 84, Issue 1Page: 94-95KeywordsBlood donorsMajor histocompatibility antigensRheumatoid arthritisRisk managementSpondylitis Issue Published: 1 January 1976 PDF downloadLoading ...