A Urinary Cryoprotein in Multiple Myeloma
Authors: PHILIP VARRIALE
Journal: Annals of Internal Medicine (1962)

Case Studies1 November 1962A Urinary Cryoprotein in Multiple MyelomaPHILIP VARRIALE, M.D., DONALD M. GINSBERG, M.D., MARTIN D. SASS, M.S.PHILIP VARRIALE, M.D.Search for more papers by this author, DONALD M. GINSBERG, M.D.Search for more papers by this author, MARTIN D. SASS, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-5-819 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMultiple myeloma is characteristically associated with one or more of 3 distinct abnormalities in protein metabolism: (a) the production of abnormal serum globulins (myeloma globulins); (b) urinary excretion of Bence Jones protein; and (c) deposition in the tissues of a protein known as paramyloid (primary amyloid). In a small percentage of cases of multiple myeloma, a cold-precipitable protein of the serum has been identified and termed a cryoglobulin (1). The purpose of this report is to present a case of multiple myeloma associated with the urinary excretion of a unique paraprotein with the combined properties of "cryoglobulin" and a Bence...References1. MACKAYERIKSENMOTULSKYVOLWILER IRNAGW: Cryo- and macroglobulinemia. Electrophoretic, ultracentrifugal and clinical studies. Amer. J. Med. 20: 564, 1956. CrossrefMedlineGoogle Scholar2. SNAPPERORES IRO: Determination of Bence Jones protein in the urine. JAMA 173: 1137, 1960. CrossrefGoogle Scholar3. BENCE JONES H: Cited in Multiple Myeloma, by Snapper, I., Turner, L. B., and Muscovitz, H. L., Grune & Stratton, New York, 1953. Google Scholar4. PUTNUM FW: In The Plasma Proteins, Vol. 2, ed. by Putnam, F. W., Academic Press, New York, 1960, p. 345. CrossrefGoogle Scholar5. WINTROBEBUELL MMMV: Hyperproteinemia associated with multiple myeloma: with report of a case in which an extra-ordinary hyperproteinemia was associated with thrombosis of the retinal veins and symptoms suggesting Raynaud's disease. Bull. Johns Hopkins Hosp. 52: 156, 1933. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New YorkFrom the Medical Service, Veterans Administration Hospital, Brooklyn, New York.Requests for reprints should be addressed to Philip Varriale, M.D., The St. Vincent's Hospital of the City of New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA rare case of IgD gammopathy associated with free light-chain cryoglobulinemia and a gelling Bence Jones proteinA unique case of kappa light-chain disease associated with cryoglobulinemia, pyroglobulinemia, and hyperviscosity syndromeConformational stability of a human cryoglobulinCryoglobulins and PyroglobulinsThermodynamic and conformational studies on an immunoglobulin light chain which reversibly precipitates at low temperaturesAmino acid sequence of the first hypervariable region of 2κ and Aλ Bence Jones cryoglobulinImmunological and physicochemical study of a crystallizable Bence-Jones cryoproteinStudies on cryoprecipitation: Covalent structure of a human IgG cryoglobulin and its gelation characteristicsThe NH2-terminal amino acid sequence of and κ and A λ Bence-Jones cyroglobulinA urinary cryo-Bence Jones protein gelling at room temperatureParaproteinämische HämoblastosenEffects of chemical modification of a Bence Jones cryoglobulinAbnormal Proteinuria in Malignant DiseasesUse of Immunoelectrophoresis and Immunodiffusion in Clinical MedicineThe Gamma GlobulinsCryoglobulinuria: Studies of a cryo-Bence Jones protein1 1 November 1962Volume 57, Issue 5Page: 819-823KeywordsAmyloid proteinsExcretionGlobulinsMedical servicesMultiple myelomaMyelomaProtein metabolismProteinsSerum proteins Issue Published: 1 November 1962 PDF DownloadLoading ...