tbuckley/cabot-search huggingface dataset:
Prospective 12-Year Follow-up Study of Clinical and Hemodynamic Sequelae After Deep Vein Thrombosis in Low-Risk Patients (Zürich Study)
Authors: Ulrich K. Franzeck, Ilse Schalch, Kurt A. Jäger, Ernst Schneider, Jörg Grimm, Alfred Bollinger
Journal: Circulation (1996)

Background No prospective study of the long-term sequelae of more than 10 years after acute deep vein thrombosis exists so far. Therefore, 58 low-risk patients with DVT were included in a prospective study to evaluate the natural history of postthrombotic syndrome. Methods and Results Clinical and hemodynamic examinations were performed at the time of admission; after 3, 6, and 12 months; after the 2nd, 3rd, 4th, 5th years; and finally after the 12th year. All patients received heparin initially and oral anticoagulants subsequently. After 12 years, 64% of the patients exhibited normal findings. Mild skin changes were found in 28%, marked trophic changes in 5%, and only one venous ulcer occurred. Regular use of compression stockings was reported by 54% of the patients with multilevel thrombosis. Although mean maximum venous outflow was significantly reduced from the acute event to 12 years later ( P &lt;.003) compared with the contralateral leg, a significant ( P &lt;.05) improvement was observed 6 months later. Recanalization of calf vein thrombosis was detected by Doppler sonography after 3 months. Sixty-four percent of the multilevel thromboses were recanalized completely or in part after 1 year; in 69%, valvular incompetence was found. Conclusions In contrast to earlier reports, this prospective study up to 12 years after deep vein thrombosis demonstrates a low incidence of postthrombotic syndrome by administration of oral anticoagulants and regular compression therapy. However, the adverse clinical event rate (mortality 14%) and a recurrence rate of 24% show that the prognosis after deep vein thrombosis does not appear favorable even in low-risk patients.
Tuberculous pleural effusion: experience with six months of treatment with isoniazid and rifampicin.
Authors: C Canete, I Galarza, A Granados, E Farrero, R Estopa, F Manresa
Journal: Thorax (1994)

BACKGROUND--Tuberculous pleurisy is associated with small numbers of bacteria. Due to the low rate of primary resistance to antituberculous drugs a two-drug regimen was used to treat the condition. METHODS--Patients received isoniazid 5 mg/kg and rifampicin 10 mg/kg daily for six months. Clinical, radiological, and haematological assessments were performed during treatment and patients were followed up for a median period of 41 (range 6-96) months. RESULTS--One hundred and thirty patients were studied with a mean age of 27 (range 11-53) years. Seven were withdrawn due to parenchymal disease and eight were lost to follow up during the treatment period. Side effects during treatment were frequent (20.7%), but only three patients required a change in medication. No treatment failures were observed. One hundred and fifteen patients completed therapy and were followed up for 41 (range 6-96) months with no evidence of a relapse. CONCLUSIONS--Tuberculous pleurisy responds well to a two-drug regimen of antituberculous therapy given for six months.
Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma
Authors: Tracy-Ann Read, Marie P. Fogarty, Shirley L. Markant, Roger E. McLendon, Zhengzheng Wei, David W. Ellison, Phillip G. Febbo, Robert J. Wechsler-Reya
Journal: Cancer Cell (2009)
Treatment of Pre-eclampsia or Toxaemia of Pregnancy
Authors: I. MacGillivray
Journal: BMJ (1964)

sidered and the logical consequences of continued autonomy studied.In the meantime, however, local medical committees have a responsibility at the forthcoming annual elections to the General Medical Services Committee of making an exchange transfusion of new blood that is so long overdue.An opportunity to make changes that may alter the whole future of general practice is upon us.It behoves us to get the intraprofessional machinery to mould those changes efficiently.These changes must evolve slowly and we must eschew haste in the moment of crisis if we are to avoid disaster.First, therefore, let us see that machinery within our own professional organizations is efficient.-Iam, etc.,
Maternal Age and Births in the 1980s
Authors: Melissa M. Adams
Journal: JAMA (1982)

Projections from the US Bureau of the Census show that as the large "baby boom" cohort ages in the 1980s, the percentage of births to women 35 years or older will increase by 37%, while the percentage of births to teenaged women, the small post-baby-boom cohort, will decrease by 32%. Between 1980 and 1990, for women aged 35 to 44 years, fertility rates are projected to increase modestly, whereas for teenagers aged 15 to 19 years, fertility rates are projected to decrease modestly. Assuming that half of pregnant women aged 35 years or older request prenatal chromosomal diagnosis, an estimated 1.1 million pregnant women aged 35 years or older will request this service during the 1980s, increasing substantially the demand for it. Simultaneously, demand for prenatal care for teenagers will decrease, due to the decrease in births to teenagers. (<i>JAMA</i>1982;247:493-494)
Contact profilometry and correspondence analysis to correlate surface properties and cell adhesion in vitro of uncoated and coated Ti and Ti6Al4V disks
Authors: Andrea Bagno, Marco Genovese, Alessandra Luchini, Monica Dettin, Maria Teresa Conconi, Anna Michela Menti, Pier Paolo Parnigotto, Carlo Di Bello
Journal: Biomaterials (2003)
Accuracy and Impact of Presumed Cause in Patients With Cardiac Arrest
Authors: Istepan Kürkciyan, Giora Meron, Wilhelm Behringer, Fritz Sterz, Andrea Berzlanovich, Hans Domanovits, Marcus Müllner, Hans C. Bankl, Anton N. Laggner
Journal: Circulation (1998)

International guidelines recommend differentiation between cardiac and noncardiac causes of cardiac arrest. The aim of this study was to find the rate of agreement between primarily postulated and definitive causes of cardiac arrest.We retrospectively analyzed the primarily presumed cause of cardiac arrest as determined by the emergency room physician on admission in all patients admitted to the emergency department of one urban tertiary care hospital. This was compared with the definitive cause as established by clinical evidence or autopsy. Within 4 years, the initially presumed cause was unclear in 24 (4%) of 593 patients. In the remaining 569 patients, the presumed cause was correct in 509 (89%) and wrong in 60 (11%) cases. Cardiac origin was presumed in 421 (71%) and the definitive cause in 408 (69%) cases. Noncardiac origin was presumed in 148 (25%) and the definitive cause in 185 (31%) patients. Presumed cardiac cause was sensitive (96%) but less specific (77%). Noncardiac causes such as pulmonary embolism, cerebral disorders, or exsanguination were those most frequently overlooked. Asystole occurred significantly more often in patients in whom presumed cause remained undetermined or differed from the definitive cause.Cause of cardiac arrest is not as easily recognized as anticipated, especially when the initial rhythm is different from ventricular fibrillation. This might affect comparability of study results, therapeutic strategies, prognosis, and outcome. Patients in whom the presumed cause was confirmed as being correct had significantly better survival and neurological outcome.
Abnormal 31P NMR stress test is predictive of myocardial events: a report from the NIH-NHLBI sponsored Women's Ischemia Syndrome Evaluation(WISE)
Authors: Gerald M. Pohost, Steven D. Buchthal, B.Delia Johnson, Hee-Won Kim, Jan A. den Hollander, Marion B. Olson, Kate N. Scott, Carl J. Pepine, Sunil Mankad, Sheryl F. Kelsey, Leslee Shaw, Noel Bairey-Merz
Journal: Journal of the American College of Cardiology (2002)
Risks and benefits of omega 3 fats: Health benefits of omega 3 fats are in doubt
Authors: Johanna M Geleijnse, Ingeborg A Brouwer, Edith J M Feskens
Journal: BMJ (2006)

EDITOR—In their systematic review of observational studies and randomised controlled trials Hooper et al conclude that omega 3 fats do not have a clear effect on overall mortality, combined cardiovascular events, or cancer.1

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We do not agree with their approach of pooling α linolenic acid (which is of vegetable origin) with omega 3 fatty acids from fish. Furthermore, fatal and non-fatal …

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Von Recklinghausen's Disease and Gastrointestinal Carcinoids
Authors: Lewis Johnson
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The occasional association of von Recklinghausen's disease (VRD) with visceral tumors, such as neurofibromas, meningiomas, gliomas, and pheochromocytomas, is well documented<sup>1</sup>; however, its association with gastrointestinal (GI) carcinoids is limited to only a few case reports.<sup>1,2</sup>The purpose of this letter is to document further this association. <h3>Report of a Case.—</h3> A 53-year-old woman with VRD since adolescence was admitted to the hospital for right-sided upperquadrant abdominal pain of 24 hours' duration. Physical examination showed several fleshy pedunculated cutaneous tumors, café-au-lait skin lesions, and a right-sided peroneal palsy. Moderate right-sided upper quadrant abdominal tenderness and guarding were observed. Total serum bilirubin value was 1.9 mg/dL (normal, 0.2 to 1.0 mg/dL) and serum alkaline phosphatase value, 129 units mU/ mL (normal, 30 to 105 mU/mL). Both ultrasonography and an upper GI series examination demonstrated a small tumorlike lesion in the second portion of the duodenum. Exploratory
Lactate-Induced IL-8 Pathway in Endothelial Cells—Response
Authors: Frédérique Végran, Emmanuel Seront, Pierre Sonveaux, Olivier Feron
Journal: Cancer Research (2012)

In a recent publication ([1][1]), we have documented the capacity of lactate to enter endothelial cells via the monocarboxylate transporter MCT1 and to signal by stimulating an autocrine proangiogenic NF-κB/interleukin-8 (IL-8) pathway. In this mechanistic study, the reason why we used human
Cutis marmorata telangiectatica congenita in two sisters
Authors: V.C. ANDREEV, K. PRAMATAROV
Journal: British Journal of Dermatology (2006)

Journal Article Cutis marmorata telangiectatica congenita in two sisters Get access V.C. ANDREEV, V.C. ANDREEV Institute of Dermatology, Academy of Medicine, Sofia, Bulgaria Search for other works by this author on: Oxford Academic Google Scholar K. PRAMATAROV K. PRAMATAROV Institute of Dermatology, Academy of Medicine, Sofia, Bulgaria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 101, Issue 3, 1 September 1979, Pages 345–350, https://doi.org/10.1111/j.1365-2133.1979.tb05630.x Published: 01 September 1979
Obesity, Rather Than Diet, Drives Epigenomic Alterations in Colonic Epithelium Resembling Cancer Progression
Authors: Ruifang Li, Sara A. Grimm, Kaliopi Chrysovergis, Justin Kosak, Xingya Wang, Ying Du, Adam Burkholder, Kyathanahalli Janardhan, Deepak Mav, Ruchir Shah, Thomas E. Eling, Paul A. Wade
Journal: Cell Metabolism (2014)
Replication of hepatitis C virus: Catching it in the act
Authors: A D Branch
Journal: Hepatology (1996)

Replication of Hepatitis C Virus: Catching It in the Act together at a relatively high density.In natural infec-SEE ARTICLE ON PAGE 205.tions, the presence of HCV 6 in macrophages [7][8][9] and Kupffer cells 10 suggests that Fc receptors, which bind In this issue of HEPATOLOGY, Shimizu et al. 1 build to a conserved portion of antibodies, may facilitate antibody-dependent entry into cells expressing Fc recep-on the foundation they helped to create, presenting electron micrographs of 50 nm virus-like particles in a tors.Yields of flaviviruses, which are in the same family as HCV, are increased up to 1,000-fold if the virus is liver sample from a hepatitis C virus (HCV) infected chimpanzee and in the cytoplasms of two types of tissue mixed with subneutralizing concentrations of antiviral antibodies before incubation with cells bearing Fc re-culture cells, a human T cell line used in previous investigations of HCV RNA replication, 2 and a human B-ceptors. 11 Further experiments are needed to determine whether Fc receptors are important for HCV in-cell line, Daudi lymphoblastoid cells.These longawaited images reveal that the morphological features fection and to seek alternate routes HCV might use to enter cells lacking Fc receptors.In the meantime, Fc of intracellular particles are similar to those of the 55 nm to 65 nm HCV particles previously described in receptors illustrate how the level of a particular cellular protein could influence HCV's cellular tropism.4][5] Immunoperoxidase staining, carried out with antibodies specific for a synthetic peptide rep-INSIDE A CELL, HCV REPLICATION IS resenting the HCV core protein and for a recombinant REGULATED version of the HCV envelope protein, was used to localize these HCV proteins in electron micrographs of the Viral expression is controlled by signals built into cultured cells.the molecular biology of the virus and by cellular fac-Compared to the cultured cells, the liver samples tors.Just as the population of surface receptors differs contained very few virus-like particles.Among 18 liver between cell types, the level of cellular factors needed tissues evaluated by immunofluorescence, 10 from for viral replication may also differ.In the case of HCV, chimpanzees and 8 from humans, only the liver tissue the rate of viral protein synthesis appears to be regufrom 1 chimpanzee contained a high enough level of lated, in part, by positive 12 and negative 13 translational HCV proteins to be judged suitable for ultrastructural control elements in the 5 untranslated region of the analysis.Why do these non-hepatic lymphocyte-deviral messenger (mRNA).Cellular and viral proteins rived tissue culture cells provide a richer source of vimay switch these RNA control elements on and off.rus-like HCV particles than liver tissues?Regulatory signals may be one way HCV handles the multiple demands placed on its pool of genomic RNA.
Fibrotic Conditions Occurring During Methysergide Therapy for Headache.
Authors: John R. Graham
Journal: Annals of Internal Medicine (1966)

s1 May 1966Fibrotic Conditions Occurring During Methysergide Therapy for Headache.John R. Graham, M.D., F.A.C.P., Howard I. Suby, M.D.John R. Graham, M.D., F.A.C.P.Search for more papers by this author, Howard I. Suby, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1184_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwente-seven patients who have developed retroperitoneal fibrosis while taking methysergide (Sansert®) for headache have been collected. In 14 patients the diagnosis was proved at operation. In 13 it was clinically established, and the process regressed upon withdrawal of the drug. Fibrosis involving the root of the aorta, heart valves, and pulmonary tissue during methysergide therapy will also be discussed and theories presented regarding the possible relationship of the drug to these conditions and the possible mechanisms involved.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John R. Graham, M.D., F.A.C.P.; Howard I. Suby, M.D.Affiliations: Jamaica Plain, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1184-1184KeywordsAortaDrug therapyDrugsFibrosisHeadachesHeartPulmonary fibrosis ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
A FEW NOTES ON EPILEPSY.
Authors: L. PIERCE CLARK
Journal: JAMA (1896)

The peculiar ideas that epileptics entertain about their attacks are well illustrated by some of their remarks in describing their seizures. Two or three characterized their fits as "dreamy spells." These were minor attacks in which consciousness was not completely lost, but there was confusion of ideas and a paralysis of will over many of the voluntary movements of the body. These have been designated as psychic attacks by some writers, but by others they are still classed with petit mal. The latter class of diagnosticians regard the subdivision, psychic, as an unnecessary refinement in classification and one not fully justifiable clinically. One patient has designated his aura in a dramatic manner by saying: "First red, white and blue, followed by a sensation of falling down, down for a long distance; then darkness." During the attenuation of consciousness, the brain has time to record many sensory phenomena. As the elements
Incidence of congenital hypothyroidism: retrospective study of neonatal laboratory screening versus clinical symptoms as indicators leading to diagnosis.
Authors: J Alm, L Hagenfeldt, A Larsson, K Lundberg
Journal: BMJ (1984)

Filter paper blood samples taken routinely from 100 239 newborn infants were radioimmunoassayed five years later for plasma thyrotrophin concentrations. In 32 cases (0.03%) these were found to be raised. Thirty one of these children were traced and subjected to follow up examination by a paediatrician and a psychologist. Of the 31 children, 15 were found to have been receiving treatment for congenital hypothyroidism since a median of 5 months of age (diagnosed group). Of the 16 others, seven children were found to have raised serum thyrotrophin concentrations and were classified as hypothyroid (undiagnosed group). The remaining nine children were euthyroid. Children in the diagnosed group had a mean Griffiths developmental quotient of 87 (control value 103; p less than 0.01), and five out of 13 showed impaired neurological development. Of the remainder, those in the undiagnosed group had a mean developmental quotient of 100 and those in the euthyroid group a mean developmental quotient of 107. In this study achieving a detection rate of congenital hypothyroidism of one in 3000 in a neonatal screening programme resulted in overdiagnosis of about a quarter of patients considered to have true positive findings. This was outweighed, however, by the early identification of all infants with the disease.
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice
Authors: John S. Welch, Wenlin Yuan, Timothy J. Ley
Journal: Journal of Clinical Investigation (2011)

Acute promyelocytic leukemia (APL) is characterized by the t(15;17) translocation that generates the fusion protein promyelocytic leukemia-retinoic acid receptor α (PML-RARA) in nearly all cases. Multiple prior mouse models of APL constitutively express PML-RARA from a variety of non-Pml loci. Typically, all animals develop a myeloproliferative disease, followed by leukemia in a subset of animals after a long latent period. In contrast, human APL is not associated with an antecedent stage of myeloproliferation. To address this discrepancy, we have generated a system whereby PML-RARA expression is somatically acquired from the mouse Pml locus in the context of Pml haploinsufficiency. We found that physiologic PML-RARA expression was sufficient to direct a hematopoietic progenitor self-renewal program in vitro and in vivo. However, this expansion was not associated with evidence of myeloproliferation, more accurately reflecting the clinical presentation of human APL. Thus, at physiologic doses, PML-RARA primarily acts to increase hematopoietic progenitor self-renewal, expanding a population of cells that are susceptible to acquiring secondary mutations that cause progression to leukemia. This mouse model provides a platform for more accurately dissecting the early events in APL pathogenesis.
Von Hippel-Lindau Disease and Pheochromocytoma
Authors: Hartmut P.H. Neumann, Charis Eng, Lois M. Mulligan
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Dr Neumann and colleagues<sup>1</sup>describe the importance of genetic testing in disease kindreds. We agree with the authors' findings, but feel further explanation would be helpful. The authors describe two von Hippel-Lindau (VHL) families that were clinically thought to have multiple endocrine neoplasia, type II (MEN-II). It has also been our experience that a small number of VHL mutations predispose to pheochromocytoma, with few other, if any, manifestations of VHL. We have seen nine individuals from three of 80 VHL families, whose sole manifestation of VHL was pheochromocytoma, similar to previous reports.<sup>2</sup> We also have seen two families in whom the occurrence of pheochromocytoma was frequent, and who were followed clinically as MEN-II families. Closer evaluation of these families revealed some findings compatible with VHL disease. One family was kindred 4942, in which among at-risk patients in three generations, six members had pheochromocytoma and one
STUDIES ON THE BACTERIOPHAGE OF D'HERELLE
Authors: J. Bronfenbrenner, R. Muckenfuss
Journal: The Journal of Experimental Medicine (1927)

We have been able to confirm the observations of Twort as well as of Gratia, that dead staphylococcus may undergo lysis if, in addition to a suitable bacteriophage, there is also present live staphylococcus. Moreover, we have endeavored to ascertain the mechanism of this phenomenon and have found that in order to elicit it it is necessary to control the numbers of live and dead bacteria in the mixture. An excess of dead bacteria interferes with lysis by adsorbing the bacteriophage before it has the opportunity to initiate necessary changes in the live bacteria, so that all lysis is prevented. The phenomenon is specific, that is, the lysis of live bacteria is accompanied by lysis of dead bacteria of the same species only. Lysis of dead bacteria occurs best with staphylococcus, an organism which easily undergoes spontaneous autolysis under appropriate conditions. In the case of B. coli or B. dysenteriae the lysis of the dead bacteria is uncertain. Dead bacteria need not be present in the mixture at the beginning of the experiment; they will be dissolved if added any time before, during, or after the completion of lysis of live bacteria. If the test is performed so that a suitable semipermeable membrane is interposed between the dead and live bacteria, the dead bacteria are not dissolved, in spite of the lysis of live bacteria on the other side of the membrane. The agent determining the lysis of dead bacteria is not diffusible, while the principle initiating the lysis of live bacteria diffuses freely and is demonstrably present on both sides of the membrane. The complete independence of the agent causing dissolution of dead bacteria from bacteriophage can also be shown by separating the two agents by means of filtration, or by adsorption on bacteria. The ferment-like substance responsible for the lysis of dead bacteria is different from the bacteriophage. It is not diffusible through collodion, it is easily adsorbed on clay filters, it is heat-labile, and is inactivated on standing. An agent possessing identical properties was found in cultures of staphylococcus undergoing spontaneous autolysis in the absence of bacteriophage, but in this instance the agent appeared in the filtrates considerably later than it did when phage was present.