Frequency of Hemoglobinopathies in Sarcoidosis
Authors: SIGMUND R. GREENBERG
Journal: Annals of Internal Medicine (1965)

Brief Communications1 January 1965Frequency of Hemoglobinopathies in SarcoidosisSIGMUND R. GREENBERG, M.D., JEAN ATWATER, B.S., HAROLD L. ISRAEL, M.D., F.A.C.P.SIGMUND R. GREENBERG, M.D., JEAN ATWATER, B.S., HAROLD L. ISRAEL, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-125 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo disorders commonly affecting american Negroes are sarcoidosis and hemoglobinopathies. There is no recorded study of their relationship, and for this reason the frequency of abnormal hemoglobin patterns in patients with sarcoidosis has been determined.METHODS AND MATERIALSOne hundred Negro patients, 31 male and 69 female, with diagnosis of sarcoidosis supported by biopsy were studied in a 2-year period at the Jefferson Hospital Sarcoidosis Clinic. The age of the patients ranged from 18 to 59 years with a mean of 33 years; none had had prior hematologic study.Hemoglobin analysis was performed on each patient's blood by lysing the...References1. SINGERCHERNOFFSINGER KAIL: Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation. Blood 6: 413, 1951. CrossrefMedlineGoogle Scholar2. SMITHCONLEY EWCL: Filter paper electrophoresis of human hemoglobins with special reference to incidence and clinical significance of hemoglobin C. Bull. Hopkins Hosp. 93: 94, 1953. MedlineGoogle Scholar3. KUNKELWALLENIUS HGG: New hemoglobin in normal adult blood. Science 122: 288, 1955. CrossrefMedlineGoogle Scholar4. GOLDBERG CA: Identification of human hemoglobins. Clin. Chem. 3: 1, 1957. CrossrefMedlineGoogle Scholar5. ROBINSONROBSONHARRISONZUELZER ARMAPWW: A new technique for differentiation of hemoglobin. J. Lab. Clin. Med. 50: 745, 1957. MedlineGoogle Scholar6. INGRAM VM: Abnormal human haemoglobins. I. Comparison of normal human and sicklecell haemoglobins by fingerprinting. Biochim. Biophys. Acta 28: 539, 1958. CrossrefMedlineGoogle Scholar7. BAGLIONI C: An improved method for the fingerprinting of human hemoglobin. Biochim. Biophys. Acta 48: 392, 1961. CrossrefMedlineGoogle Scholar8. HUISMANMEYERING THCA: Studies on the heterogeneity of hemoglobin. I. The heterogeneity of different human hemoglobin types in carboxymethyl-cellulose and in Amberlite IRC-50 chromatography: qualitative aspects. Clin. Chim. Acta 5: 103, 1960. CrossrefMedlineGoogle Scholar9. BAGLIONILEHMANN CH: Chemical heterogeneity of haemoglobin O. Nature 196: 229, 1962. CrossrefMedlineGoogle Scholar10. BAGLIONIINGRAM CVM: Abnormal human haemoglobins. V. Chemical investigation of haemoglobins A, G, C, X from one individual. Biochim Biophys. Acta 48: 253, 1961. CrossrefMedlineGoogle Scholar11. ATWATERSCHWARTZTOCANTINS JIRLM: A variety of human hemoglobin with four distinct electrophoretic components. Blood 15: 901, 1960. CrossrefMedlineGoogle Scholar12. MYERSONHARRISONLOHMULLER RMEHW: Incidence and significance of abnormal hemoglobins. Amer. J. Med. 26: 543, 1959. CrossrefMedlineGoogle Scholar13. SCHNEIDER RG: Incidence of electrophoretically distinct abnormalities of hemoglobin in 1,550 Negro hospital patients. Amer. J. Clin. Path. 26: 1270, 1956. CrossrefMedlineGoogle Scholar14. HAYNIEDOBSONHETTIG TPHLRA: Molecular diseases of hemoglobin. I. Introduction and incidence. Ann. Intern. Med. 46: 1031, 1957. LinkGoogle Scholar15. CHERNOFF AI: On the prevalence of hemoglobin D in the American Negro. Blood 11: 907, 1956. CrossrefMedlineGoogle Scholar16. GOLDSTEINRATPON GPANIJMINNICH MANV: The incidence of elevated hemoglobin A2 levels in the American Negro. Ann. Intern. Med. 60: 95, 1964. LinkGoogle Scholar17. ISRAELSONES HLM: Sarcoidosis—clinical observation on one hundred and sixty cases. Arch. Intern. Med. (Chicago) 102: 766, 1958. CrossrefGoogle Scholar18. BUCKMCKUSICK AAVA: Epidemiologic investigations of sarcoidosis. III. Serum proteins, syphilis; association with tuberculosis; familial aggregation. Amer. J. Hyg. 74: 174, 1961. MedlineGoogle Scholar19. JÖRGENSENWURM GK: The ABO blood group in sarcoidosis. International Conference on Sarcoidosis, Stockholm, 1963. Google Scholar20. LEWISWOODS JGAC: The ABO and Rhesus blood groups in patients with respiratory disease. Tubercle 42: 362, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Sarcoidosis Clinic and the Charlotte Drake Cardeza Foundation of Jefferson Medical College Hospital, Philadelphia, Pa.Requests for reprints should be addressed to Harold L. Israel, M.D., Jefferson Medical College, 1025 Walnut St., Philadelphia, Pa. 19107. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySARCOIDOSIS PRESENTING WITH MASSIVE SPLENOMEGALY IN A CHILD WITH A HISTORY OF IRIDOCYCLITIS AND SENSORINEURAL DEAFNESSSickle cell disease, pulmonary hypertension, and sarcoidosisHemoglobin C/β+ thalassemia and sarcoidosisSarcoidosisHemoglobin Studies in SarcoidosisRICHARD J. HIRSCHMAN, B.A., CAROL J. JOHNS, M.D. 1 January 1965Volume 62, Issue 1Page: 125-128KeywordsAttentionBiopsyBiostatisticsBloodGeneticsHemoglobinHemoglobinopathiesHospitalsSarcoidosis Issue Published: 1 January 1965 PDF DownloadLoading ...