tbuckley/cabot-search huggingface dataset:
John Deryk Wallace Whitney
Authors: P. Wright
Journal: BMJ (2001)

Pioneer of cardiovascular gene therapy dies from a heart attack aged 53Jeffrey Isner opened up an entirely new field of revascularisation research using angiogenesis techniques to stimulate new blood vessel growth and bypass clogged vessels.At the time of Isner's death, his work was still considered visionary, yet investigational.Proof of principle had been demonstrated, but randomised trials were just getting under way.In 1994, Isner used a gene transfer technique to grow new blood vessels that could bypass damaged vessels in a patient with critical limb ischaemia and leg pain at rest.The technique delivered the protein vascular endothelial growth factor, or VEGF, through a balloon into the wall of the artery close to the blockage.The gene transfer technique was subsequently made "more straightforward, using intramuscular injection," according to Douglas Losordo, a coinvestigator with Isner at St Elizabeth's Hospital in Boston.By 1998, Isner's team performed the first procedures in the heart, injecting VEGF directly into the cardiac muscle through the chest wall.In 1999, Isner pioneered a catheter based approach.At the American Heart Association scientific sessions on 13 November 2001, two weeks after Isner's death, co-investigators reported his most recent research results.American Heart Association president David Faxon said that although a phase I trial of 19 patients using myocardial VEGF-2 gene transfer with a catheter showed "significant improvement in angina, exercise tolerance, imaging, and increased profusion, only safety-not efficacy-was
Similar topology of injury to keratinocytes and myofibres in dermatomyositis skin and muscle
Authors: S.A. Greenberg, D. Fiorentino
Journal: British Journal of Dermatology (2008)

Journal Article Similar topology of injury to keratinocytes and myofibres in dermatomyositis skin and muscle Get access S.A. Greenberg, S.A. Greenberg Department of Neurology, Brigha and Women's Hospital, Harvard Medical School, Boston, MA 02458, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar D. Fiorentino D. Fiorentino Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, U.S.A. E‐mail:sagreenberg@partners.org Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 2, 1 February 2009, Pages 464–465, https://doi.org/10.1111/j.1365-2133.2008.08967.x Published: 01 February 2009
786 ROLE OF LXRALPHA AND ITS LIPOGENIC TARGET GENES IN THE PATHOGENESIS OF HCV-RELATED STEATOSIS IN AN IN VITRO MODEL
Authors: M.V. García-Mediavilla, E. Lima, S. Pisonero-Vaquero, B. Merino-Antolín, P.L. Majano, I. Benedicto, J.L. Olcoz, J. González-Gallego, S. Sánchez-Campos
Journal: Journal of Hepatology (2010)
Tumors of the eye and adnexa in infancy and childhood.
Authors: Leonard Apt
Journal: JAMA (1963)

This work is a "personal experience" type of monograph. It is not an extensive review of all tumors that have been seen in the eye and adnexa of infants and children, but rather a presentation of those tumors that have been encountered by the authors. In the introductory chapter of the 141-page monograph, the authors first outline the general features of tumors in the pediatric patients and then briefly discuss irradiation therapy. In the remaining four chapters, tumors of the eyelid, the conjunctiva, the inner eye, and the orbit are reviewed. Dr. Iliff succinctly presents the operative steps, accompanied by simple-to-follow drawings, for exenteration and the lateral and nasal surgical approach to the orbit. The text is written in an unusually clear, concise, factual, easy-to-read manner. The book is well illustrated. The black-and-white pictures are for the most part satisfactory, but important details have no doubt been lost in many
Personal Exposure to Ultrafine Particles and Oxidative DNA Damage
Authors: Peter S. Vinzents, Peter Møller, Mette Sørensen, Lisbeth E. Knudsen, Ole Hertel, Finn Palmgren Jensen, Bente Schibye, Steffen Loft
Journal: Environmental Health Perspectives (2005)

Exposure to ultrafine particles (UFPs) from vehicle exhaust has been related to risk of cardiovascular and pulmonary disease and cancer, even though exposure assessment is difficult. We studied personal exposure in terms of number concentrations of UFPs in the breathing zone, using portable instruments in six 18-hr periods in 15 healthy nonsmoking subjects. Exposure contrasts of outdoor pollution were achieved by bicycling in traffic for 5 days and in the laboratory for 1 day. Oxidative DNA damage was assessed as strand breaks and oxidized purines in mononuclear cells isolated from venous blood the morning after exposure measurement. Cumulated outdoor and cumulated indoor exposures to UFPs each were independent significant predictors of the level of purine oxidation in DNA but not of strand breaks. Ambient air concentrations of particulate matter with an aerodynamic diameter of < or = 10 microm (PM10), nitrous oxide, nitrogen dioxide, carbon monoxide, and/or number concentration of UFPs at urban background or busy street monitoring stations was not a significant predictor of DNA damage, although personal UFP exposure was correlated with urban background concentrations of CO and NO2, particularly during bicycling in traffic. The results indicate that biologic effects of UFPs occur at modest exposure, such as that occurring in traffic, which supports the relationship of UFPs and the adverse health effects of air pollution.
Informed Consent and the First Amendment
Authors: Wendy K. Mariner, George J. Annas
Journal: New England Journal of Medicine (2015)

Interview with Prof. Wendy Mariner on state laws that regulate physicians’ speech and behavior in the context of abortion. (07:18)Download In recent years, U.S. states have been adding to the requirements for physicians seeking “informed consent.” Now, an appeals court decision striking down a North Carolina statute on pre-abortion ultrasonography may bring the issue back before the Supreme Court.
Prior treatment with the tyrosine kinase inhibitors dasatinib and nilotinib allows stem cell transplantation (SCT) in a less advanced disease phase and does not increase SCT Toxicity in patients with chronic myelogenous leukemia and philadelphia positive acute lymphoblastic leukemia
Authors: A Shimoni, M Leiba, M Schleuning, G Martineau, M Renaud, M Koren-Michowitz, E Ribakovski, P le Coutre, R Arnold, F Guilhot, A Nagler
Journal: Leukemia (2008)
What Patients Really Want From Health Care
Authors: Allan S. Detsky
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated urinary excretion of the C5b-9 complex in membranous nephropathy
Authors: Matthias Schulze, James V. Donadio, Charles J. Pruchno, Patricia J. Baker, Richard J. Johnson, Rolf A.K. Stahl, Sandra Watkins, Donald C. Martin, Reinhard Wurzner, Otto Gotze, William G. Couser
Journal: Kidney International (1991)
Hepatic fat content is a determinant of postprandial triglyceride levels in type 2 diabetes mellitus patients with normal fasting triglyceride
Authors: Hataikarn Nimitphong, Sith Phongkitkarun, Chatchalit Rattarasarn, Atthana Kongsooksai, Suwannee Chanprasertyothin, Pong-Amorn Bunnag, Gobchai Puavilai
Journal: Metabolism (2008)
Abstract LB-154: COX-2 as a mediator of oncogenic PKCε in prostate cancer.
Authors: Rachana Garg, Priti Lal, Jorge Blando, Fernando J. Benavides, Michael D. Feldman, Emer M. Smyth, Marcelo G. Kazanietz
Journal: Cancer Research (2013)

Abstract Protein kinase C epsilon (PKCε), a member of the PKC family of phorbol ester/diacylglycerol receptors, is up-regulated in many human cancers, including prostate cancer. We recently demonstrated that PKCε is an essential mediator of NF-κB activation in prostate cancer (Garg et al., JBC, 287 (44), 37570–37582, 2012). Cyclooxygenase-2 (COX-2), a well-known NF-κB regulated gene, has been reported to be up-regulated in a number of human cancers, including metastatic prostate cancer. As PKCε plays an important role in prostate cancer cell survival and cooperates with other oncogenic insults, herein we aim to determine if PKCε regulates COX-2 activation during prostate tumorigenesis. PKCε RNAi depletion diminishes TNFα- or LPS-induced COX-2 mRNA expression in LNCaP prostate cancer cells and constitutive COX-2 levels from PC3 cells. Conversely, PKCε overexpression by adenoviral means potentiates TNFα or LPS-induced COX-2 expression in LNCaP cells. Notably, transgenic overexpression of PKCε in the mouse prostate causes preneoplastic lesions with elevated COX-2 levels. Interestingly, when we intercrossed the prostate-specific PKCε transgenic mice with mice haploinsufficient for Pten, a common genetic alteration in human prostate cancer, the resulting compound mutant mice (PB-PKCε;Pten+/− mice) developed fully invasive adenocarcinoma with NF-κB hyperactivation and high COX-2 levels. Likewise, stable overexpression of PKCε in mouse prostate epithelial cell lines that are either heterozygous (P8) or homozygous (CaP8) for Pten deletion, led to significant enhancements in cell proliferation, motility and invasiveness as well as in LPS-induced COX-2 mRNA expression compared to the respective control cells, and this effect is more pronounced in CaP8 cells. Studies using human prostate tumors revealed a co-existence of PKCε overexpression, NF-κB hyperactivation, and COX-2 up-regulation. Lastly, treatment of PKCε overexpressing P8 or CaP8 cells with the selective COX-2 inhibitor NS398 caused a pronounced growth inhibition. Overall, our study identified COX-2 as a PKCε-regulated gene. Our results suggest that COX-2 as a potential mediator of PKCε oncogenesis in prostate cancer, particularly in the context of Pten loss. Citation Format: Rachana Garg, Priti Lal, Jorge Blando, Fernando J. Benavides, Michael D. Feldman, Emer M. Smyth, Marcelo G. Kazanietz. COX-2 as a mediator of oncogenic PKCε in prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-154. doi:10.1158/1538-7445.AM2013-LB-154
THE SURGICAL TREATMENT OF AURAL POLYPI.
Authors: P. B. WING
Journal: JAMA (1896)

It is the purpose of this paper to describe in a brief and concise manner the treatment which I have found most effectual for the permanent removal of those morbid growths known and described as aural polypi. Gruber defines aural polypus as a neoplasm originating in the auditory canal or in the deeper parts of the ear, which is pedunculated and consists principally of histologic elements of the soft connective tissue order. Granulations springing from a broader base are generally called polypoid proliferations. These growths have received a great variety of names by different writers, but I am of the opinion that no observer can say that this is a mucous polypus or a fibrous, but that he will find a combination of both mucous and fibroid tissue. I am also of the opinion that all polypi are at the very commencement granulation tissue and that as they grow in
An unusual cause of pain in both hips
Authors: I G S Lim
Journal: Annals of the Rheumatic Diseases (2003)

In August 2001, a 55 year old renal physician presented with a three week history of a painful right hip. There was no obvious precipitating factor. The pain was situated over the outer aspect of the right hip as well as the groin, with intermittent radiation down to the right knee. At times, he needed to place a pillow between his knees to feel comfortable when lying down. Despite these symptoms, he was able to walk freely around Vienna on holiday.

On examination, there was pain on external rotation of the right hip as well as discomfort at the extremes of abduction and adduction. There was no tenderness over the greater trochanter.

An x ray examination of the right hip was normal. Magnetic resonance imaging (MRI) disclosed a bilobed 2 cm “collar-stud” cystic lesion, with one lobe intracapsular and the other extracapsular, just inferior to the lateral edge of the right acetabulum (fig 1). …
Association Between Celiac Disease and Iron Deficiency in Caucasians, but Not Non-Caucasians
Authors: Joseph A. Murray, Stela McLachlan, Paul C. Adams, John H. Eckfeldt, Chad P. Garner, Chris D. Vulpe, Victor R. Gordeuk, Tricia Brantner, Catherine Leiendecker–Foster, Anthony A. Killeen, Ronald T. Acton, Lisa F. Barcellos, Debbie A. Nickerson, Kenneth B. Beckman, Gordon D. McLaren, Christine E. McLaren
Journal: Clinical Gastroenterology and Hepatology (2013)
Experimental and Clinical Studies on Rifampicin in Treatment of Leprosy
Authors: R. J. W. Rees, J. M. H. Pearson, M. F. R. Waters
Journal: BMJ (1970)

Rifampicin showed high activity against experimental leprosy, inhibiting the multiplication of dapsone-sensitive and dapsone-resistant strains of Mycobacterium leprae in mice fed 5 mg./kg. body weight. In a formal pilot-type trial on six previously untreated patients with active lepromatous leprosy, rifampicin (600 mg. daily by mouth) was as effective as standard treatment with dapsone. Myco. leprae, however, appeared to be killed more rapidly by rifampicin than by dapsone or other antileprosy drugs so far studied. This was confirmed on a further 10 patients, including two with dapsone resistance, and from the infectivity in mice of bacilli recovered from patients during treatment with rifampicin or dapsone. These results are consistent with the bactericidal activity of rifampicin against other micro-organisms, which could be important to the chemotherapy of leprosy, since all antileprosy drugs in current use are bacteriostatic.
UK agency recommends better monitoring of multidrug resistant <i>E coli</i>
Authors: Susan Mayor
Journal: BMJ (2005)

The Health Protection Agency, the body that monitors and advises on infectious diseases in the United Kingdom, has recommended that monitoring of multidrug resistant Escherichia coli be improved. Its report, published this week, shows a big increase over the past four years in the number of infections associated with the bacterium.

The agency found that the number of infections caused by E coli bacteria that produce extended spectrum β lactamase (ESBL) was growing. Extended spectrum β lactamase is an enzyme that hydrolyses and confers resistance to modern cephalosporin antibiotics. The increase has occurred in the …
Coexistence of Adenocarcinoma of the Jejunum and Nontropical Sprue
Authors: Charles G. Moertel
Journal: JAMA (1961)

CASES IN WHICH adenocarcinoma of the jejunum coexisted with nontropical sprue recently have been reported from the Massachusetts General Hospital 1 and by Joske. 2 Interest in this apparently rare combination of disease entities has been accentuated by the speculation of Joske that the atrophic jejunitis of nontropical sprue may be precancerous. The following case is the first in which this combination was observed at the Mayo Clinic and is also, to our knowledge, the third to appear in the literature.  Report of a Case  A 68-year-old Caucasian man of professional employ was seen in February, 1960, with the problems of anemia and upper abdominal distress. He had been seen periodically since 1933 for general examinations and for minor ailments. From that time until 1949 he had reported no symptoms referable to the bowel, and the value for hemoglobin had ranged between 12.9 gm. and 13.5 gm. per 100
Doctors working in prisons
Authors: L. Birmingham
Journal: BMJ (2002)

Until very recently responsibility for health care in prisons in England and Wales lay with the home office, the government department responsible for the criminal justice system. Under this arrangement the National Health Service, the provider of statutory health care for the general public, was not obliged to provide a service for people in prison.

The Prison Service has struggled to cope with the huge healthcare burden imposed by sick prisoners, particularly those with problems related to mental health and substance misuse, and it has been repeatedly criticised for providing inferior health care.1 Previous reports focusing on doctors working in prisons found that recruitment was a real problem, prison doctors were inadequately trained, and they were working beyond the limits of their ability. 2 3

Pressure for a modern day reform of health care in prisons increased significantly following the publication of Patient or Prisoner ?4 in which the chief inspector of prisons …
Book: The President of England
Authors: S. Harrison
Journal: BMJ (2000)

Jim Waits Minerva Press, £13.99, pp 305 ISBN 0 75411 073 7 Rating: ![Graphic][1]</img>![Graphic][2]</img> Some familiar characters appear in this novel, written by a retired NHS chief executive, including a “Democratic Labour” government taking office after the Conservatives under Thatcher and Major, a strong modernising prime minister whose initials are AB, an apparently ruthlessly cynical spin doctor, a popular and (as it transpires) wily old queen, an unpopular heir to the throne, and a dead princess. The prime minister's secret agenda is to declare a republic of … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Lipoxin A4 (LXA4) and Leukotriene C4 (LTC4) Levels in Nasal Lavages after Intranasal Provocation with Aspirin in Aspirin Sensitive and Aspirin Tolerant Patients
Authors: M. Kupczyk, I. Kupry´s-Lipi´nska, M. Boche´nska-Marciniak, A. Antczak, P. Górski, P. Kuna
Journal: Journal of Allergy and Clinical Immunology (2006)
Medicine's Number One Problem
Authors: Howard A. Rusk
Journal: New England Journal of Medicine (1953)

IMPROVEMENT in the health of the people in the developed parts of the world since 1900 constitutes one of the great achievements of the past half-century. It has been estimated, from fossil findings, that in prehistoric times the average man lived about eighteen years, his life frequently terminating in violent death. This had advanced to around twenty-five during the time of the ancient Romans. However, in 1940 in the United States, the average person could expect to live to be sixty-two, in Sweden to sixty-seven, in Canada to sixty-four, in Finland to fifty-eight, in the Netherlands to sixty-six, and in . . .
Renal and Hepatic Function Improve in Advanced Heart Failure Patients During Continuous-Flow Support With the HeartMate II Left Ventricular Assist Device
Authors: Stuart D. Russell, Joseph G. Rogers, Carmelo A. Milano, David B. Dyke, Francis D. Pagani, Juan M. Aranda, Charles T. Klodell, Andrew J. Boyle, Ranjit John, Leway Chen, H. Todd Massey, David J. Farrar, John V. Conte
Journal: Circulation (2009)

Background— The effects of continuous blood flow and reduced pulsatility on major organ function have not been studied in detail. Methods and Results— We evaluated renal (creatinine and blood urea nitrogen) and hepatic (aspartate transaminase, alanine transaminase, and total bilirubin) function in 309 (235 male, 74 female) advanced heart failure patients who had been supported with the HeartMate II continuous-flow left ventricular assist device for bridge to transplantation. To determine whether patients with impaired renal and hepatic function improve over time with continuous-flow left ventricular assist device support or whether there are any detrimental effects in patients with normal organ function, we divided patients into those with above-normal and normal laboratory values before implantation and measured blood chemistry over time during left ventricular assist device support. There were significant improvements over 6 months in all parameters in the above-normal groups, with values in the normal groups remaining in the normal range over time. Mean blood urea nitrogen and serum creatinine in the above-normal groups decreased significantly from 37±14 to 23±10 mg/dL ( P &lt;0.0001) and from 1.8±0.4 to 1.4±0.8 mg/dL ( P &lt;0.01), respectively. There were decreases in aspartate transaminase and alanine transaminase in the above-normal groups from 121±206 and 171±348 to 36±19 and 31±22 IU ( P &lt;0.001), respectively. Total bilirubin for the above-normal group was 2.1±0.9 mg/dL at baseline; after an acute increase at week 1, it decreased to 0.9±0.5 mg/dL by 6 months ( P &lt;0.0001). Both renal and liver values from patients in the normal groups remained normal during support with the left ventricular assist device. Conclusions— The HeartMate II continuous-flow left ventricular assist device improves renal and hepatic function in advanced heart failure patients who are being bridged to transplantation, without evidence of detrimental effects from reduced pulsatility over a 6-month time period. Clinical Trial Registration Information— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00121472.
Diarrhoeal disease and malnutrition
Authors: A. Tomkins
Journal: Gut (1986)

<h3>Background and Aims</h3> Systemic lupus erythematous (SLE) is a heterogeneous autoimmune disease with environmental and genetic contributing factors. The gut microbiota (GM) interacts with the immune system to maintain homeostasis. However, microbiome dysbiosis has been shown to lead to the development of autoimmune diseases. We aimed to investigate the role of GM in SLE-prone BAFF-Tg mice and study the possible benefit of GM-targeted treatments. <h3>Methods</h3> We used 16S metagenomics to compare the GM composition, before or after disease onset, and before or after treatment of established disease with several different fibre-enriched diets or antibiotics. Gut bacteria composition was identified by sequencing V3-V4 regions on an Illumina MiSeq platform in a 96-plex library configuration, and bioinformatics analysis was performed using QIIME software. Matching data on mouse disease levels was obtained by flow cytometry, autoantibody ELISA, and kidney histology. <h3>Results</h3> BAFF-Tg mice exhibited distinct GM compositions compared to WT, both before and after disease onset, with certain families of bacteria expanded or replaced prior to disease progression. GM-targeted therapy by high-fibre dietary modulation or antibiotics reduced anti-dsDNA autoantibodies to undetectable levels. <h3>Conclusions</h3> GM dysbiosis, of some particular bacterial species we identified, can be linked to the level of disease development in this lupus-prone mouse model. Therapeutic strategies targeting GM, including easily implementable dietary modulations and antibiotics, could be investigated further as novel avenues for treating and managing SLE.