tbuckley/cabot-search huggingface dataset:
Leukocyte Alkaline Phosphatase in Sickle-Cell Anemia
Authors: Takeshi Wajima, Alfred P. Kraus
Journal: New England Journal of Medicine (1975)

LEUKOCYTE alkaline phosphatase scores are often lower than control values in patients with sickle-cell anemia.1 , 2 This difference is especially marked in such patients with leukocytosis, in whom we have observed that leukocyte alkaline phosphatase scores increase during bacterial infections, in contrast to painful, febrile crises.Materials and MethodsForty-one patients with electrophoretically proved sickle-cell anemia were studied during the steady state. Leukocyte alkaline phosphatase scores were again obtained in 25 of these cases during a vaso-occlusive crisis without evidence of infection. All patients with crisis had some degree of fever. Sixteen were restudied during bacterial infections with or without a . . .
CLINICAL STUDY ON MORTALITY AND MORBIDITY OF PATIENTS WITH EISENMENGER SYNDROME -JAPANESE MULTICENTER STUDY
Authors: Hisanori Sakazaki, Koichiro Niwa, Makoto Nakazawa, Tsutomu Saji, Toshio Nakanishi, Motoki Takamuro, Michihiko Ueno, Hitoshi Katou, Shinichi Takatsuki, Seiki Matsushima, Namiko Kojima, Fukiko Ichida, Shigetoyo Kogaki, Sachiko Kido, Yoshio Aragaki, Kenji Waki, Teiji Akagi, Kunitaka Jo, Atsushi Souuchi, Kenji Suda
Journal: Journal of the American College of Cardiology (2010)
The Extent and Character of Drug Consumption During Pregnancy
Authors: Paul L. Doering
Journal: JAMA (1978)

One hundred sixty-eight obstetrical patients' conditions were monitored prospectively throughout the prenatal, perinatal, and postpartum periods to obtain data on maternal drug consumption. In the prenatal period, all patients received at least two different drug products: 93.4% received five or more, while one patient reported taking 32 different products. The average number of drug products used in the prenatal period was 11.0. The mean perinatal exposure in patients undergoing vaginal delivery was 7.0. Analysis by therapeutic category was performed. Information gathered confirms the fact that pregnant women do take a large number of different types of medications, the consequences of which remain unknown.
Manufacturers in the Secular Press.
Authors: W. S. Fullerton
Journal: JAMA (1897)

Duluth, Minn, March 3, 1897. <h3>To the Editor:</h3> —Permit me through your columns to call the attention of the regular profession throughout the United States to the fact that McKesson &amp; Robbins of New York, hitherto considered by medical practitioners a reputable firm, have recently adopted the methods of the patent medicine vendors in putting upon the market a remedy for the cure of a certain disease and advertising the same to the general public through the secular press, as witness the following from the<i>Literary Digest</i>of Feb. 20, 1897. This speaks for itself, and should not be allowed to pass unnoticed by the profession at large, to which this house is looking chiefly for support. Yours truly, "Tartarlithine, the new cure for rheumatism. L. E. B., Clifton Hotel, Ottawa, Ill., writes: 'On Sunday, April 5, 1896, I was introduced to a citizen of this city who had not
Systems Analysis of Adverse Drug Events-Reply
Authors: David J. Cullen
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Dickey and Mr Hatlie challenge our estimates of the extent of iatrogenic injury as "sweeping and scientifically invalid" because they are based "solely" on the MPS. Unfortunately, those results were consistent with results from a 1975 California study that showed an adverse event rate of 4.2%. Both undoubtedly underestimated the extent of injury because they relied on information recorded in medical records. As every physician knows, all events are not recorded in the medical record. In addition, neither study measured adverse events in the outpatient setting. A recent study in Australia, using MPS methodology, found an adverse event rate of 16%.<sup>1</sup> We agree with Dickey and Hatlie that the health care system is safe for the vast majority of patients and that health care professionals are dedicated to preventing injuries, points we have made repeatedly to the press and public. We have never questioned the commitment
Survival After Ovarian Cancer Treatment
Authors: Fabio Levi
Journal: JAMA (1993)

<h3>To the Editor.</h3> —In the article by Hand et al,<sup>1</sup>significantly improved survival rates were shown in patients with stage III ovarian cancer who received platinum-based chemotherapy as compared with those who did not. In order to provide further population-based evidence on the favorable impact of platinumcontaining drugs, we took advantage of data on incident cases of ovarian cancer in the Registry of the Swiss Canton of Vaud (1980 population of about 530000). A more detailed description of the pathological characteristics and prognostic factors of these patients is provided elsewhere.<sup>2</sup>Since information on treatment was absent, for the present comparison purposes, two calendar periods were chosen (1974 through 1981 and 1982 through 1988) on the basis of the time when platinum-containing drugs spread in Switzerland (J. de Vasconcellos, MD, Institute for Medical Information and Statistics, Zing, Switzerland, written communication, September 1992). A total of 649 new ovarian primary
LESIONS CAUSED IN SUCKLING MICE BY CERTAIN VIRUSES ISOLATED FROM CASES OF SO CALLED NON-PARALYTIC POLIOMYELITIS AND OF PLEURODYNIA
Authors: Alwin M. Pappenheimer, Joan B. Daniels, F. S. Cheever, T. H. Weller
Journal: The Journal of Experimental Medicine (1950)

A study has been made of the lesions produced in suckling mice by the following viruses: Powers, Matulaitis, DeMole, Kine, McCarthy, Conn. 5, Ohio R, High Point, WS No. 4, EMC, and Col. SK. Pathologic alterations have been found in myocardium, lungs, liver, pancreas, thymus, brain and spinal cord, adipose tissue, and skeletal muscles. A comparison of the lesions produced by the individual strains has disclosed certain differential features which are discussed in detail. Within the group of so called Coxsackie viruses, myositis has not proved to be a constant finding, and it may occur in suckling mice infected with other types of virus.
Food-Borne Streptococcal Pharyngitis in a Hospital Pediatrics Clinic
Authors: Michael D. Decker
Journal: JAMA (1985)

After a potluck luncheon, more than half the staff of a hospital pediatrics clinics became ill. Group A Streptococcus (M precipitin, nontypable; T agglutination type, 8/25; and serum opacity reaction, positive) was isolated from 12 of the 20 ill persons. Food-consumption analysis implicated a rice dressing as the vehicle of transmission. The dressing was prepared by a clinic employee in whom pharyngitis had developed three weeks before the luncheon. This is an unusual outbreak in that the implicated food product was not institutionally or commercially prepared and was not preponderantly composed of milk, eggs, or meat.
TCT-597 Predictors of Stent Expansion After Drug-eluting Stents: An ADAPT-DES IVUS substudy
Authors: Nobuaki Kobayashi, Gary S. Mintz, Bernhard Witzenbichler, D. Christopher Metzger, Michael Rinaldi, Ernest L. Mazzaferri, Peter L. Duffy, Giora Weisz, Thomas Stuckey, Bruce R. Brodie, Ke Xu, Gregg Stone, Akiko Maehara
Journal: Journal of the American College of Cardiology (2013)
Visual space is not cognitively impenetrable
Authors: Yiannis Aloimonos, Cornelia Ferm&uuml;ller
Journal: Behavioral and Brain Sciences (1999)

Cognitive impenetrability (CI) of a large part of visual perception is taken for granted by those of us in the field of computational vision who attempt to recover descriptions of space using geometry and statistics as tools. These tools clearly point out, however, that CI cannot extend to the level of structured descriptions of object surfaces, as Pylyshyn suggests. The reason is that visual space – the description of the world inside our heads – is a nonEuclidean curved space. As a consequence, the only alternative for a vision system is to develop several descriptions of space–time; these are representations of reduced intricacy and capture partial aspects of objective reality. As such, they make sense in the context of a class of tasks/actions/plans/purposes, and thus cannot be cognitively impenetrable.
Surgery and salmonella
Authors: G Stansby, K Dawson, G Hamilton
Journal: BMJ (1990)

phenomenon.' Thev refer, however, to onlyr one study, and although this studv showed an improvement in finger cutaneous blood flow, it showed no change in either the number or the severity of Raynaud's attacks.Subjective benefit has been claimed in other studies of captopril both in patients with primary Raynaud's phenomenon and in those with secondary disease, but these studies were either uncontrolled or confined to case reports.By contrast, the double blind placebo controlled studv of Madsen and Hvidt did not support these claims."Furthermore, our results of a double blind placebo controlled study of enalapril showed no evidence ofeither objective or subjective improvement during treatment for one month.rWe believe that at present there is insufficient evidence to support the use of angiotensin con- verting enzyme inhibitors in patients with Raynaud's phenomenon.Nevertheless, further controlled studies are required to determine whether there is a dose dependent response to these inhibitors and to resolve the disparity between the subjective and objective effects seen in some studies.
Abstract LB-41: Rictor undergoes GSK3-dependent, FBXW7-mediated ubiquitination and proteasomal degradation.
Authors: Junghui Koo, Xiayun Wu, Ping Yue, Zixu Mao, Fadlo R. Khuri, Shi-Yong Sun
Journal: Cancer Research (2013)

Abstract Rictor directly interacts with mTOR and other proteins to form an important complex (i.e., mTOR complex 2, mTORC2) that plays critical role in regulation of cellular homeostasis primarily by phosphorylating some AGC kinases such as Akt, PKC and SGK. Moreover, rictor also exerts biological functions such as regulation of protein degradation by interacting with other proteins independent of mTORC2. However the degradation of rictor itself and underlying mechanism are largely unknown and thus are the focuses of this study. We found that inhibition of proteasome with the proteasome inhibitor MG132 increased rictor levels accompanied with elevated rictor ubiquitination. Consistently inhibition of F-box and WD repeat domain-containing 7 (FBXW7; also known as FBW7 and CDC4) with various genetic means including knockdown, knockout and enforced expression of a dominant-negative mutant inhibited rictor ubiquitination and increased rictor levels, whereas enforced expression of FBXW7 decreased rictor stability and levels. Moreover, we detected an interaction between FBXW7 and rictor by immunoprecipitation. Hence, rictor is degraded through a FBXW7-mediated ubiquitination/proteasome mechanism. This process is dependent on GSK3 because GSK3 was associated with rictor and directly phosphorylated the Thr1695 site in a putative CPD motif of rictor; mutation of this site impaired the interaction between rictor and FBXW7, decreased rictor ubiquitination and increased rictor stability. Collectively we conclude that rictor undergoes GSK3-dependent, FBXW7-mediated ubiquitination and proteasomal degradation. (J Koo and X Wu contributed equally to this work. This study was supported by Georgia Cancer Coalition Distinguished Cancer Scholar award and NIH R01 CA118450, R01 CA160522 and P01 CA116676. FR Khuri and S-Y Sun are Georgia Cancer Coalition Distinguished Cancer Scholars.) Citation Format: Junghui Koo, Xiayun Wu, Ping Yue, Zixu Mao, Fadlo R. Khuri, Shi-Yong Sun. Rictor undergoes GSK3-dependent, FBXW7-mediated ubiquitination and proteasomal degradation. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-41. doi:10.1158/1538-7445.AM2013-LB-41
Isointegral analysis of body surface maps: surface distribution and temporal variability in normal subjects.
Authors: T J Montague, E R Smith, D A Cameron, P M Rautaharju, G A Klassen, C S Felmington, B M Horacek
Journal: Circulation (1981)

Isointegral analysis of body surface potential maps has been proposed as a useful approach to data reduction.To determine the normal magnitude and surface distribution of a series of time-integral measurements, we acquired body surface potential maps from 40 men and 15 women, ages 20-46 years, who were clinically normal.In a subset of 16 subjects, variability in serial maps was assessed as the root-mean- square difference in time-integral values between maps using the same electrode application (recordings separated by 15 minutes) as well as when different electrode applications were required (recordings separated by 1-7 days).Isointegral maps of the QRS, ST-T, QRST, ST-segment and Q-zone time integrals all demonstrated pre- dominantly bipolar body surface distributions, with positive values located over the precordium and negative values over the right chest and back.Men had significantly (p < 0.05) greater maximum and minimum values than women for all time integrals except Q zone.Variability in serial maps was small and was significantly greater (p < 0.001) between maps acquired with different, compared to the same, electrode application.More- over, variability tended to be greatest for time integrals that reflected repolarization events.We conclude that time-integral analysis of body surface potential mapping is a practical method for data reduction that holds considerable promise as a technique to rapidly assess the ECG effects of many drugs and interventions.Variability in sequential maps is small but must be considered before serial alterations in time integrals are accepted as meaningful.
Who saw the "histological findings"?
Authors: B. Deer
Journal: BMJ (2011)

We recently added to our series “Secrets of the MMR scare” with more on the claim that Wakefield and colleagues discovered a new inflammatory bowel disease.1 This was one of two sides to the infamous Lancet paper—the other linking the vaccine with autism.2

The paper said that “histological findings” of colitis were made in 11 of 12 children. “Formalin fixed biopsy samples of …
Laboratory Tests in Infectious Mononucleosis
Authors: Robert A. McDougal
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The answer to a question about the diagnostic value of the quantitative heterophile titer in QUESTIONS AND ANSWERS (239:440, 1978) contains some misleading information. First and most important, the heterophile test of Davidsohn is a two-stage test, the test antigen being sheep RBCs. This antigen reacts with the antibody of infectious mononucleosis (IM) and the Forssman antibody. Absorption of the patient's serum is required to remove the latter. The "mononucleosis tests" have an antigen of stabilized or specially processed horse RBCs for a simple, rapid, and accurate slide-test detection of the antibody of IM. They do not react with the Forssman antibody and thus do not "measure the same antibody" as the answer states. Miale<sup>1</sup>states that his laboratory uses the slide test exclusively, and Wintrobe<sup>2</sup>states that it is 99% accurate. I would agree that a titer (of horse RBCs) does not add to
THE DETAILS OF THE PHOTOGRAPHICALLY RECORDED VENOUS PULSE IN AURICULAR FIBRILLATION
Authors: Walter L. Niles, Carl J. Wiggers
Journal: The Journal of Experimental Medicine (1917)

While auricular fibrillation is easily recognized by arterial and jugular tracings or by electrocardiograms, it is not possible to interpret all the waves found in these records. The venous tracings may in general be placed in one of two classes: (a) those in which prominent systolic waves predominate or occur alone; and (b) those in which large or small diastolic waves occur occasionally, in groups, or in a continued series averaging 250 to 500 per minute. The prominent systolic waves have generally been attributed to tricuspid regurgitation, the inference being that tricuspid regurgitation is a common state in auricular fibrillation. The diastolic waves are so numerous and so many electrocardiograms show diastolic waves that it is impossible to account for them on the assumption that the auricle is in a dilated and finely fibrillating state. It has been suggested that in these instances a condition of coarse fibrillation, which is closely allied to auricular flutter, obtains. The systolic and diastolic waves of the venous pulse of twenty-five clinical cases of auricular fibrillation, recorded by photographic methods, were studied. Six types of systolic waves (Text-Fig. 1) were found: (1) an intensified impact wave, the most common and often the only characteristic feature, indicating vigorous ventricular action; (2) a peaked impact followed by a rapid systolic drop due to light pressure of the tambour; (3) the intra-auricular type of systolic variation, so called from its resemblance to intra-auricular pressure curves found in animals, occurring in clinical cases only when ventricular systole is weak; (4) double systolic waves, attributed to a systolic tug of the ventricle on the auricles and large veins; (5) a systolic impact followed by a stasis wave, present when intravenous pressure is high; (6) a regurgitation wave composed of a steep rise continued into a systolic plateau with murmur vibrations superimposed. Our study showed (1) that tricuspid regurgitation, as indicated by the presence of regurgitation waves, is a rare accompaniment of auricular fibrillation; and (2) that the contrary opinion, arrived at by the frequent presence in polygraph tracings of ventricular types of waves, is due to the fact that the contour of intensified impact waves is distorted by polygraph levers so that they simulate regurgitation waves. Recurrent diastolic waves were frequently present in our records. Their relative size depended, to a considerable extent, on the pressure of the tambour. There was no constant relation to similar waves in the recorded electrocardiogram, nor is it proven that they are indicative of a coarse type of fibrillation or an associated flutter.
Complications of Local Corticosteroid Injections-Reply
Authors: Norman L. Gottlieb
Journal: JAMA (1981)

In Reply.—  Although local corticosteroid injection treatment of rheumatic disorders has been widely practiced for several decades, the optimal dose and frequency of administration and the preferred preparation are controversial. Exemplifying the contrasting opinions on the former issues, Bentley and Goodefellow 1 conclude that even a single injection requires strong justification, while Balch et al 2 have administered 15 injections in four years to 167 injections in 12 years to 65 knees of patients with rheumatoid arthritis or osteoarthritis with little detrimental effect. Coonrad and Hooper 3 have injected 290 patients with lateral epicondylitis (tennis elbow) from one to 13 times at two-week- to six-month intervals with gratifying results and few complications.  We are not in disagreement with Dr Neustadt's position that local corticosteroid treatment generally is safe and effective and that adverse reactions are in part directly related to the frequency of injection. At the present time, however, in
Childhood Diabetes and Intensive Insulin Therapy-Reply
Authors: Mitchell E. Geffner
Journal: JAMA (1983)

<h3>In Reply.—</h3> Dr Baptist's letter interprets our report to indicate that multiple insulin injections are mandatory for good glycemic control. In fact, this is not necessarily implied. What is mandatory is that good control be achieved, and, as we indicated, in most patients this requires multiple injections. The group of patients in whom this may not be necessary, as implied by Dr Baptist, may be "protected" early in the course of their diabetes, when endogenous insulin secretion may still contribute to modulation of control. However, in our experience and that of others,<sup>1</sup>the vast majority of patients do not fall into this group. We would also prefer not to leave the reader with the idea that multiple insulin injections, as opposed to one, are necessarily more traumatic to parent or child. Depending on how the initial experience is handled, the number of injections usually is not a problem. Conversely,
FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2
Authors: Tao Zuo, Runhua Liu, Huiming Zhang, Xing Chang, Yan Liu, Lizhong Wang, Pan Zheng, Yang Liu
Journal: Journal of Clinical Investigation (2007)

S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle dysregulation and carcinogenesis; however, the genetic lesions that cause this upregulation are poorly understood. We recently demonstrated that forkhead box P3 (FOXP3) is an X-linked breast cancer suppressor and an important repressor of the oncogene ERBB2/HER2. Since FOXP3 suppresses tumor growth regardless of whether the tumors overexpress ERBB2/HER2, additional FOXP3 targets may be involved in its tumor suppressor activity. Here, we show that mammary carcinomas from mice heterozygous for a Foxp3 mutation exhibited increased Skp2 expression. Ectopic expression of FOXP3 in mouse mammary cancer cells repressed SKP2 expression with a corresponding increase in p27 and polyploidy. Conversely, siRNA silencing of the FOXP3 gene in human mammary epithelial cells increased SKP2 expression. We also show that Foxp3 directly interacted with and repressed the Skp2 promoter. Moreover, the analysis of over 200 primary breast cancer samples revealed an inverse correlation between FOXP3 and SKP2 levels. Finally, we demonstrated that downregulation of SKP2 was critical for FOXP3-mediated growth inhibition in breast cancer cells that do not overexpress ERBB2/HER2. Our data provide genetic, biochemical, and functional evidence that FOXP3 is a novel transcriptional repressor for the oncogene SKP2.
Patients can opt out of controversial national records system
Authors: Michael Day
Journal: BMJ (2007)

NHS patients in England will be able opt out of a controversial national medical records system, the government has said. 

The government's U turn comes after growing concerns about the risks to patients' privacy when their medical details are transferred to a national NHS system. After a task force that was set up to investigate the new system expressed similar fears in its report, health minister Norman Warner said on 18 December that the Department of Health would allow concerned patients to opt out of the summary care record system. 

“If patients don't want to have information upload, they can stop it before it …
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
Authors: Wing-Kin Sung, Hancheng Zheng, Shuyu Li, Ronghua Chen, Xiao Liu, Yingrui Li, Nikki P Lee, Wah H Lee, Pramila N Ariyaratne, Chandana Tennakoon, Fabianus H Mulawadi, Kwong F Wong, Angela M Liu, Ronnie T Poon, Sheung Tat Fan, Kwong L Chan, Zhuolin Gong, Yujie Hu, Zhao Lin, Guan Wang, Qinghui Zhang, Thomas D Barber, Wen-Chi Chou, Amit Aggarwal, Ke Hao, Wei Zhou, Chunsheng Zhang, James Hardwick, Carolyn Buser, Jiangchun Xu, Zhengyan Kan, Hongyue Dai, Mao Mao, Christoph Reinhard, Jun Wang, John M Luk
Journal: Nature Genetics (2012)