tbuckley/cabot-search huggingface dataset:
Immunotherapy with an alum‐adsorbed <i>Parietaria</i>‐pollen allergoid: a 2‐year, double‐blind, placebo‐controlled study
Authors: M. G. Tari, M. Mancino, E. Ghezzi, E. Frank, O. Cromwell
Journal: Allergy (1997)

A double‐blind, placeo‐controlled study was performed in order to confirm the safety, suitability, and efficacy of an alum‐adsorbed Parietaria judaica ‐pollen allergoid, Allergovit®, for allergen‐specific immunotherapy. Parietaria pollen is an important cause of pollinosis, particularly in the Mediterranean zone, where it may be encountered for up to 8–9 months of the year. It is an aggressive allergen, and the doses tolerated during immunotherapy are less than those achieved with grass pollen. This factor increases the desirability of using therapeutic preparations with minimal IgE‐binding activity, such as allergoids, in order to reduce the risk of side‐effects and enable patients to tolerate a higher dose of allergen, thereby increasing the chances of successful specific immunotherapy. Forty patients with rhinitis and/or asthma were allocated at random to active‐ or placebo‐treatment groups at the beginning of the study. All patients received the active preparation during the second year of the study. Immunotherapy was well tolerated by all patients and the incidence of side‐effects was low. Treatment resulted in significant reductions in specific cutaneous reactivity and increases in nasal tolerance. A progressive improvement in nasal inspiratory peak flow in association with the immunotherapy indicated a reduction in nasal inflammation. These objective assessments of efficacy endorsed the results from the patients’ diary cards, which indicated significant improvements in symptoms and reductions in the use of medication. The immunologic activity of the therapeutic preparation was demonstrated by the induction of a significant specific‐IgG antibody response, with increases in IgG4 during the second year of treatment. We conclude that the safety and efficacy of immunotherapy with the Parietaria allergoid make it suitable for consideration in the treatment of patients with Parietaria ‐pollen‐induced rhinitis or asthma.
Triglyceride Concentration and Ischemic Heart Disease
Authors: J ørgen Jeppesen, Hans Ole Hein, Poul Suadicani, Finn Gyntelberg
Journal: Circulation (1998)

Background —The role of triglycerides as a risk factor of ischemic heart disease (IHD) remains controversial. For the present study, we examined the relation between fasting triglycerides and risk of IHD in the Copenhagen Male Study. Methods and Results —Baseline measurements of fasting lipids and other IHD risk factors were obtained for 2906 white men (age range, 53 to 74 years) who were initially free of overt cardiovascular disease. During an 8-year follow-up period, 229 men had a first IHD event. Crude cumulative incidence rates of IHD were 4.6% for the lowest, 7.7% for the middle, and 11.5% for the highest third of triglyceride levels ( P for trend &lt;.001). Compared with the lowest third level and adjusted for age, body mass index, alcohol, smoking, physical activity, hypertension, non–insulin-dependent diabetes mellitus, social class, and LDL and HDL cholesterol, relative risks of IHD (95% confidence interval) were 1.5 (1.0 to 2.3; P =.05) and 2.2 (1.4 to 3.4; P &lt;.001) for the middle and highest third of triglyceride levels, respectively. When triglyceride levels were stratified by HDL cholesterol levels (triglyceride third multiplied by HDL cholesterol third), a clear gradient of risk of IHD was found with increasing triglyceride levels within each level of HDL cholesterol, including high HDL cholesterol level, which are thought to provide protection against IHD. Conclusions —In middle-aged and elderly white men, a high level of fasting triglycerides is a strong risk factor of IHD independent of other major risk factors, including HDL cholesterol.
Anomalous pulmonary venous return with intact atrial septum: diagnosis and pathophysiology.
Authors: J S Alpert, L Dexter, W V Vieweg, F W Haynes, J E Dalen
Journal: Circulation (1977)

Twenty-one patients with partial anomalous pulmonary venous drainage with intact atrial septum have been studied. These include 13 patients not previously reported from our laboratories and eight patients with complete hemodynamics reported by others. Methods for identification of this abnormality and for identification of an intact atrial septum are described, including differential indicator dilution curves, catheter probing of the atrial septum and pulmonary angiography. Blood flow through anomalously draining lobes of the lung is usually higher than through normally drainage lobes attributable to the higher pressure differences across the anomalous lung, right atrial pressure being uniformly lower than left atrial pressure. The pulmonary vascular resistance when "standardized" to the flow of blood normally present in different portions of the lung indicated that no significant differences existed between normally and anomalously draining lobes. Six patients had coexisting rheumatic mitral stenosis and one had congenital mitral stenosis. Its influence on the hemodynamic changes produced by PAPVD is discussed.
Defence questions validity of evidence against cardiologist facing charges of sex abuse
Authors: C. Dyer
Journal: BMJ (2011)

An internationally renowned paediatric cardiologist who is facing allegations of sexual abuse of children at the General Medical Council is challenging a decision to admit hearsay evidence against him.

A barrister for Philipp Bonhoeffer, former head of cardiology at London’s Great Ormond Street Hospital for Children, asked two judges at the High Court in London to quash the decision of a GMC fitness to practise panel as irrational and a breach of his right to a fair trial.

Professor Bonhoeffer, who is suspended from the medical register under an interim order and no longer works at Great Ormond Street, is one of the world’s …
Serious Adverse Effects Can Occur With Minor Procedures
Authors: Mitchell H. Katz
Journal: JAMA Internal Medicine (2013)

Sejal Chowdhary, BS; Bolanle Bukoye, MPH, BS; Arjun M. Bhansali, MD; Alexander R. Carbo, MD; May Adra, RPh; Sheila Barnett, MD; Mark D. Aronson, MD; Daniel A. Leffler, MD, MS
Remaking Medicaid: Managed Care for the Public Good
Authors: Oliver Fein
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes2 February 1999Remaking Medicaid: Managed Care for the Public GoodOliver Fein, MDOliver Fein, MDCornell University Medical College, New York, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-3-199902020-00042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Davidson SM, Somers SA; eds. 387 pages. San Francisco: Jossey-Bass; 1998. $45.95. ISBN 0787940429. Order phone 415-433-1767.Field of medicine: Health policy and management and Medicaid managed care.Format: Hardcover book.Audience: Physicians, administrators, policymakers, and advocates for Medicaid recipients.Purpose: To explore the essential elements of the managed care strategy for Medicaid.Content: This book is a collection of 18 essays by health services researchers that analyze Medicaid managed care, its historical context, its implementation in several states, its applicability to disabled and other special needs populations, and its potential for monitoring quality and provider performance. Because more and ... Author, Article, and Disclosure InformationAffiliations: Cornell University Medical College, New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 February 1999Volume 130, Issue 3Page: 251-252KeywordsElderlyForecastingHealth careHealth care providersHealth care qualityHealth care utilizationHealth insuranceMedical servicesPopulation statisticsResearch quality assessment ePublished: 15 August 2000 Issue Published: 2 February 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hypermethylated Genes as Biomarkers of Cancer in Women with Pathologic Nipple Discharge
Authors: Mary Jo Fackler, Aeisha Rivers, Wei Wen Teo, Amrit Mangat, Evangeline Taylor, Zhe Zhang, Steve Goodman, Pedram Argani, Ritu Nayar, Barbara Susnik, Saraswati Sukumar, Seema A. Khan
Journal: Clinical Cancer Research (2009)

In a pilot study of women with pathologic nipple discharge (PND) undergoing ductoscopy, we tested quantitative assessment of gene promoter hypermethylation using quantitative multiplex methylation-specific PCR (QM-MSP) to enhance detection of duct carcinoma in situ (DCIS).Women with PND underwent ductoscopy; ducts with significant lesions were surgically resected (36 ducts in 33 women) and those with minimal findings were not (28 ducts in 16 women). QM-MSP was done on ductoscopy cell samples. Results were compared with cytology and tissue histology.Cells from ducts with significant lesions on ductoscopy had significantly higher levels of methylation than those with minimal findings. Furthermore, cells from ducts with DCIS displayed higher levels of methylation than those with benign lesions such as papilloma (P = 0.006); or ducts with minimal findings on ductoscopy (P = 0.0001). Cumulative RASSF1A, TWIST1, and HIN1 gene methylation accurately distinguished ducts with cancerous versus benign lesions (100% sensitivity, 72% specificity, and area under the curve of 0.91 according to receiving operating characteristic analyses). QM-MSP analysis was more informative than cytology (100% versus 29% sensitivity, respectively), for detecting DCIS. In a validation set of paraffin-embedded DCIS and papilloma samples from women presenting with PND, QM-MSP was significantly higher in DNA from DCIS than papilloma sections (P = 0.002).The positive predictive value of ductoscopy was more than doubled (19% versus 47%) with the addition of QM-MSP, demonstrating the benefit of targeting ducts having both high methylation and significant abnormalities on ductoscopy for surgical excision. Future large-scale studies to validate this approach are needed.
Urine Fluorescence in Ethylene Glycol Poisoning
Authors: Christopher M McStay, Peter E Gordon
Journal: New England Journal of Medicine (2007)

A 38-year-old man presented to the emergency department after reportedly ingesting antifreeze. He appeared to be intoxicated and was agitated and combative; chemical sedation was induced. Initial laboratory studies revealed a pH of 7.0, an anion gap of 22 mmol per liter, and an osmolar gap of 79 mOsm. It was noted that the patient's urine fluoresced under ultraviolet light (in the basin on the left), as compared with a negative control (in the basin on the right), which shows the purple reflection of the ultraviolet light (arrow). The patient received fomepizole, thiamine, folate, pyridoxine, and bicarbonate; he subsequently underwent . . .
Trends in Cigarette Smoking in the United States
Authors: Michael C. Fiore
Journal: JAMA (1989)

Trends in the prevalence, initiation, and cessation of cigarette smoking are reported for the US population using weighted and age-standardized data from seven National Health Interview Surveys (1974 to 1985). The decline in prevalence was linear, with the prevalence for men decreasing at 0.91 percentage points per year to 33.5% in 1985 and the prevalence for women decreasing at 0.33 percentage points per year to 27.6% in 1985. For whites the rate of decline (percentage points per year) was 0.57, to 29.4% in 1985, and for blacks the decline was 0.67, to 35.6% in 1985. Smoking cessation increased among all gender-race groups from 1974 to 1985, with the yearly rate of increase (in percentage points per year) about equivalent for blacks (0.75) and whites (0.77), while it was higher in women (0.90) than in men (0.67). Smoking initiation decreased among young men (-1.03), while it remained about the same in young women (+0.11). Initiation decreased at a more rapid rate in blacks (-1.02) than in whites (-0.35). We conclude that smoking prevalence is decreasing across all race-gender groups, although at a slower rate for women than men, and that differences in initiation, more than cessation, are primarily responsible for the converging of smoking prevalence rates among men and women.
Unicef calls for more action to reduce maternal deaths in developing world
Authors: J. Zarocostas
Journal: BMJ (2008)

Progress has been “far too slow,” and interventions must be scaled up to reduce maternal deaths, a Unicef report says.

Each year more than half a million women die through complications in pregnancy and childbirth, with more than 99% of deaths that occur in poor countries, says the report. Each year an estimated 10 million women also experience injuries, infections, disease, or disability, which can cause lifelong suffering, it adds.

“Most of these deaths and disabilities are avoidable. Where deliveries are overseen by skilled health personnel and access to emergency obstetrical care, and where women receive adequate nutrition and basic health care services, the risk of maternal death is less,” said Ann Veneman, Unicef’s executive director.

“The causes of maternal mortality are clear, as are the means to combat them,” said Peter Salama, Unicef’s chief of health. “Yet women continue to die …
Population Pharmacokinetics Analysis of Regorafenib and Its Active Metabolites From the Phase III Correct Study of Metastatic Colorectal Cancer
Authors: Zuzana Jirakova Trnkova, Axel Grothey, Alberto Sobrero, Salvatore Siena, Alfredo Falcone, Marc Ychou, Yves Humblet, Olivier Bouché, Laurent Mineur, Carlo Barone, Antoine Adenis, Josep Tabernero, Takayuki Yoshino, Heinz Joseph Lenz, Frank Cihon, Andrea Wagner, Stefanie Reif, Jean Smeets, Konstanze Diefenbach, Dirk Laurent, Eric Van Cutsem
Journal: Annals of Oncology (2013)
A cradle of reform
Authors: N. Black
Journal: Journal of the Royal Society of Medicine (2007)

This is the third of four articles that provides the background to one of the walks in a new book, Walking London's Medical History, which aims are to tell the story of how health services developed, to help preserve our legacy of buildings and to inform current debates about health care.Walking London's Medical History is available from the RSM Press website: http:// www.rsmpress.co.uk/
The periodontal membrane in systemic sclerosis
Authors: N.R. ROWELL, F.E. HOPPER
Journal: British Journal of Dermatology (1977)

The periodontal membrane is markedly involved in about 30% of patients with systemic sclerosis and some widening occurs in about 20% of the teeth at risk. Thickening of the periodontal membrane is not specific to systemic sclerosis and can occur with clinically obvious chronic periodontal disease and, to a mild extent, in normal individuals in whom it mainly involves the coronal third of the teeth. In systemic sclerosis the whole root is more likely to be involved. There is no direct relationship in systemic sclerosis between widening of the periodontal membrane and other systemic changes, and prognosis.
Thyroiditis and Phosphatase
Authors: GILBERT H. DANIELS
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 August 1978Thyroiditis and PhosphataseGILBERT H. DANIELS, M.D., FARAHE MALOOF, M.D.GILBERT H. DANIELS, M.D.Search for more papers by this author, FARAHE MALOOF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-2-288_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the paper by Dalovisio and co-workers in the April issue, "Subacute Thyroiditis with Increased Serum Alkaline Phosphatase" (Ann Intern Med88:505-507, 1978). The authors may be interested to learn that Vogt (1) reported a similar case and three of our four patients reported in 1977 (2) also had elevated serum alkaline phosphatase concentrations....References1. VOGT J: Subacute thyroiditis with elevated serum alkaline phosphatase level. Acta Endocrinol (Kbh) 34:256-260, 1960 CrossrefGoogle Scholar2. WEIHLDANIELSRIDGWAYMALOOF AGEF: Thyroid function tests during the early phase of subacute thyroiditis. J Clin Endocrinol Metab 44:1107-1114, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harvard Medical School Boston, MA 02114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1978Volume 89, Issue 2Page: 288-288KeywordsAttentionPhosphatasesThyroid Issue Published: 1 August 1978 PDF DownloadLoading ...
Autopsies Should Be Performed on All Cases
Authors: Victor Tchertkoff
Journal: JAMA (1989)

<h3>To the Editor. —</h3> The criteria for autopsy adopted by the Joint Commission on Accreditation of Healthcare Organizations listed in the editorial by Dr Lundberg<sup>1</sup>state: "MS.8.1.7.3 The Medical staff, with other appropriate hospital staff, develops and uses criteria that identify deaths in which an autopsy should be performed." This leaves the fox in charge of the hen house. The purpose of an autopsy is to correlate clinical and anatomic findings and to unearth findings not suspected by the attending physician that may or may not have had an impact on the care of the patient at hand or of future patients. If "obvious" cases are excluded, if uninteresting "stroke" cases are excluded, and if the criteria are laid down by "appropriate hospital staff," the current sad state of the autopsy service will prevail. The old adage still holds true: "There are no uninteresting cases, only uninterested physicians." Autopsies
Patterns of molecular evolution among paralogous floral homeotic genes
Authors: A. L. Lawton-Rauh, E. S. Buckler, M. D. Purugganan
Journal: Molecular Biology and Evolution (1999)

The plant MADS-box regulatory gene family includes several loci that control different aspects of inflorescence and floral development. Orthologs to the Arabidopsis thaliana MADS-box floral meristem genes APETALA1 and CAULIFLOWER and the floral organ identity genes APETALA3 and PISTILLATA were isolated from the congeneric species Arabidopsis lyrata. Analysis of these loci between these two Arabidopsis species, as well as three other more distantly related taxa, reveal contrasting dynamics of molecular evolution between these paralogous floral regulatory genes. Among the four loci, the CAL locus evolves at a significantly faster rate, which may be associated with the evolution of genetic redundancy between CAL and AP1. Moreover, there are significant differences in the distribution of replacement and synonymous substitutions between the functional gene domains of different floral homeotic loci. These results indicate that divergence in developmental function among paralogous members of regulatory gene families is accompanied by changes in rate and pattern of sequence evolution among loci.
Improving Consistency in Cervical Cytology Reporting
Authors: H Mitchell
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Improving Consistency in Cervical Cytology Reporting Get access Heather Mitchell Heather Mitchell Victorian Cervical Cytology RegistryCarlton South, Australia * See “Notes” section following “References.” Heather Mitchell, M.D., F.R.A.C.P., F.A.F.P.H.M., Medical Director, P.O. Box 161, Carlton South, Australia 3053. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 19, 6 October 1993, Pages 1592–1596, https://doi.org/10.1093/jnci/85.19.1592 Published: 06 October 1993 Article history Received: 03 March 1993 Revision received: 28 June 1993 Accepted: 06 July 1993 Published: 06 October 1993
FIVE INTESTINAL OPERATIONS ON THE SAME PATIENT
Authors: H. Hartley
Journal: BMJ (1918)

&tK"CAL Yov FIVE TNT a collodion dressiing and thie last cervical and first dlorsal laminae removed.This was done piecemeal, as the laminae were represented by an indefinite mass of old and new bone, aind it was very difficult to determine wlhen the spinal canal was reached.This was, lhowever, eventuallv well opened up, the fatty sheath -separated, anid the theca well exposedl and lifted gently to free it.PLilsation good.Wound closed without d rainage.Three days afterwards the patient volunteered that lie could " feel his feet."Lower limbs immobile, very spastic, and involuntary movemenits as trotublesome as ever.Within tenl darys the patient could, lhowever, control the " spinal convutl- sions," and considerable mulseular power was evident.By the end of June he could Nwalk without support, and on August 25tht was invalided, walking qnite normallv.Reflexes active, no clonus, anaesthesia about upper part of thorax.CASE II.
Formulating Priorities for Quality Assurance Activity
Authors: John W. Williamson
Journal: JAMA (1978)

Quality assurance activity seems to have had little documented impact in terms of improving patient health or reducing care costs. One reason may be the lack of a practical and effective decision process for selecting priority areas where improvement of health or any other target outcome will most likely be achieved. This article describes a structured procedure for meeting this need. In addition, results of 14 years of quality assurance experience with structured and nonstructured topic selection procedures in 23 multispecialty group clinics and their associated hospitals are briefly reviewed. On the basis of this experience it is suggested that this priority method is both feasible and practical and can be recommended for application to most quality assurance systems. It is especially suited for planning medical care evaluation studies of the Professional Standards Review Organizations or the performance evaluation projects of the Joint Commission on the Accreditation of Hospitals.
In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry
Authors: Joan E. Nichols, Joaquin Cortiella, Jungwoo Lee, Jean A. Niles, Meghan Cuddihy, Shaopeng Wang, Joseph Bielitzki, Andrea Cantu, Ron Mlcak, Esther Valdivia, Ryan Yancy, Matthew L. McClure, Nicholas A. Kotov
Journal: Biomaterials (2008)