A New Synthetic Thyroid Hormone Combination for Clinical Therapy
Authors: HERBERT A. SELENKOW
Journal: Annals of Internal Medicine (1967)

Article1 July 1967A New Synthetic Thyroid Hormone Combination for Clinical TherapyHERBERT A. SELENKOW, M.D., F.A.C.P., MARVIN S. WOOL, M.D.HERBERT A. SELENKOW, M.D., F.A.C.P.Search for more papers by this author, MARVIN S. WOOL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-90 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThyroid hormone preparations of animal origin have been used extensively for over three quarters of a century. Their striking metabolic effects in correcting human thyroid insufficiency are well-known to physicians, and their therapeutic use in suppression of goiter as well as in non-thyroidal metabolic disorders is common practice. Less appreciated, however, are the variations in potency and hormonal constitution that may occur among preparations derived from the same or from different animal species or that are a consequence of a particular method of processing (1-9). Widely varying or even impotent preparations of commercially available thyroid (3, 4, 6, 10-12) can...References1. DEVLINSTEPHENSON WFNR: The chemical determination of liothyronine and thyroxine in enzymic hydrolysates of pork thyroid. J. Pharm. Pharmacol. 14: 597, 1962. CrossrefMedlineGoogle Scholar2. WIBERGDEVLINSTEPHENSONCARTERBAYNE GSWFNRJRAJ: A comparison of the thyroxine: triiodothyronine content and biological activity of thyroid from various species. Ibid., p. 773. Google Scholar3. PILEGGIGOLUBLEE VJOJND: Determination of thyroxine and triiodothyronine in commercial preparations of desiccated thyroid and thyroid extract. J. Clin. Endocr. 25: 949, 1965. CrossrefGoogle Scholar4. DEVLINWATANABE WFH: Thyroxin-triiodothyronine concentrations in thyroid powders. J. Pharm. Sci. 55: 390, 1966. CrossrefMedlineGoogle Scholar5. LEMIEUXTALMAGE RJM: The determination of liothyronine and thyroxine in thyroid preparations. J. Pharm. Pharmacol. 18: 94, 1966. CrossrefMedlineGoogle Scholar6. KOLOGLUSCHWARTZCARTER SHLAC: Quantitative determination of the thyroxine, triiodothyronine, monoiodotyrosine and diiodotyrosine content of desiccated thyroid. Endocrinology 78: 231, 1966. CrossrefMedlineGoogle Scholar7. WCOLSELENKOW MSHA: Physiologic combinations of synthetic thyroid hormones in myxedema. Clin. Pharmacol. Ther. 6: 710, 1965. CrossrefMedlineGoogle Scholar8. MACGREGOR AG: Why does anybody use thyroid B.P.? Lancet 1: 329, 1961. CrossrefMedlineGoogle Scholar9. STASILLIKROC NRRL: Biologic activity of pork and beef thyroid preparations. J. Clin. Endocr. 16: 1595, 1956. CrossrefGoogle Scholar10. CATZGINSBURGSALENGER BES: Clinically inactive thyroid U.S.P. A preliminary report. New Eng. J. Med. 266: 136, 1962. CrossrefMedlineGoogle Scholar11. WILLIAMSMEISTERFLORSHEIM ADLWH: Chemical identification of defective thyroid preparations. J. Pharm. Sci. 52: 833, 1963. CrossrefMedlineGoogle Scholar12. WILLIAMSMEISTERFAIRCLOTHFLORSHEIM ADLMWH: Significance of phosphorous-nitrogen ratio in U.S.P. thyroid. J. Pharm. Sci. 53: 1415, 1964. CrossrefMedlineGoogle Scholar13. ZAKWILLARDMYERSBOYLE BHHGAJ: Chloric acid method for determination of protein bound iodine. Anal. Chem. 24: 1345, 1952. CrossrefGoogle Scholar14. SCHOENHEIMERSPERRY RWM: Micromethod for the determination of free and combined cholesterol. J. Biol. Chem. 106: 745, 1934. CrossrefGoogle Scholar15. MITCHELLHARDENO'ROURKE MLABME: The in vitro resin sponge uptake of triiodothyronine I-131 from serum in thyroid disease and in pregnancy. J. Clin. Endocr. 20: 1474, 1960. CrossrefMedlineGoogle Scholar16. STERLINGBRENNER KMA: Free thyroxine in human serum: simplified measurement with the aid of magnesium precipitation. J. Clin. Invest. 45: 155, 1966. CrossrefGoogle Scholar17. CLARKHORN FDB: Assessment of thyroid function by the combined use of the serum protein-bound iodine and resin uptake of 131-I triiodothyronine. J. Clin. Endocr. 25: 39, 1965. CrossrefMedlineGoogle Scholar18. SELENKOWASPER HASP: The effectiveness of L-triiodothyronine or L-thyroxine administered orally in treatment of myxedema. J. Clin. Endocr. 15: 285, 1955. CrossrefGoogle Scholar19. TAPLEY DF: Pharmacology treatment, in The Thyroid, 2nd ed., edited by WERNER, S. C. Harper & Row, Publishers, New York, 1962, p. 817. Google Scholar20. SELENKOWINGBAR HASH: Diseases of the thyroid, in Principles of Internal Medicine, edited by HARRISON, T. H., ADAMS, R. D., BENNETT, I. L., JR., RESNIK, W. H., THORN, G. W., WINTROBE, M. M. McGraw-Hill Book Co., New York, 1965, p. 421. Google Scholar21. WILLIAMSBAKKE RHJL: The thyroid, in Textbook of Endocrinology, 3rd ed., edited by WILLIAMS, R. H. W. B. Saunders Co., Philadelphia, 1962, p. 96. Google Scholar22. WISWELL JG: The diagnosis and treatment of primary and secondary hypothyroidism, in Current Concepts in Hypothyroidism, edited by CRISPELL, K. R. The Macmillan Co., New York, 1963, p. 117. Google Scholar23. ASTWOOD EB: Thyroid and antithyroid drugs, in The Pharmacological Basis of Therapeutics, 3rd ed., edited by GOODMAN, L. S., GILMAN, A. The Macmillan Co., New York, 1965, p. 1466. Google Scholar24. SELENKOWHOLLANDER HACS: Physiologic, pharmacologic and therapeutic considerations in surgery for hyperthyroidism. Anesthesiology 24: 425, 1963. CrossrefMedlineGoogle Scholar25. HERBSTSELENKOW ALHA: Hyperthyroidism during pregnancy. New Eng. J. Med. 273: 627, 1965. CrossrefMedlineGoogle Scholar26. DANOWSKILIMAYESUNDERCOHNMOSES TSNRJHREC: Hydrocortisone and/or desiccated thyroid in physiologic dosage. XVII. Major and minor thyroidal indices during therapy with large doses of desiccated thyroid. Metabolism 14: 950, 1965. CrossrefMedlineGoogle Scholar27. CESANODE MARTINISDOGLIOLAURORUSSO LCRRP: [Distribution of the thyroid hormone between the maternal and fetal compartments] (Ital.). Boll. Soc. Ital. Biol. Sper. 42: 210, 1966. MedlineGoogle Scholar28. DENAYERMALVAUXVAN DEN SCHRIECKBECKERSDEVISSCHER PPHGCM: Free thyroxine in maternal and cord blood. J. Clin. Endocr. 26: 233, 1966. CrossrefGoogle Scholar29. MARKSHAMLINZACK JFMP: Neonatal thyroid function. II. Free thyroxine in infancy. J. Pediat. 68: 559, 1966. CrossrefGoogle Scholar30. SELENKOWWOOL HAMS: Thyroid hormones, in Topics in Medicinal Chemistry, edited by RABINOWITZ, J., MYERSON, R. M. John Wiley, Philadelphia, 1967. Google Scholar31. BRAVERMANINGBAR LESH: Anomalous effects of certain preparations of desiccated thyroid on serum protein-bound iodine. New Eng. J. Med. 270: 439, 1964. CrossrefMedlineGoogle Scholar32. LAVIETESEPSTEIN PHFH: Thyroid therapy of myxedema: a comparison of various agents with a note on the composition of thyroid secretion in man. Ann. Intern. Med. 60: 79, 1964. LinkGoogle Scholar33. WERMER PL: Thyroid gland preparations (correspondence). JAMA 166: 401, 1958. CrossrefGoogle Scholar34. HUBATA JA: Thyroid stability demonstrated (correspondence). Idem. Google Scholar35. Editorial: Thyroid outdated. Pharm. J. 186: 131, 1961. Google Scholar36. FRIEND DG: Suggestions for improving drug therapy. Clin. Pharmacol. Ther. 7: 276, 1966. CrossrefMedlineGoogle Scholar37. HUNTSEIDELL RA: Commercial thyroid preparations and suggestions as to the standardization of thyroid. JAMA 51: 1385, 1908. CrossrefGoogle Scholar38. TAYLOR S: A new thyroid preparation (letter to the editor). Lancet 1: 341, 1961. CrossrefGoogle Scholar39. ODDIEFISHEREPPERSON THDAD: Effect of exogenous thyroxine on thyroid accumulation and secretion in euthyroid subjects. J. Clin. Endocr. 25: 1196, 1965. CrossrefGoogle Scholar40. WYNN JO: Components of the serum protein-bound iodine following administration of I-131-labelled hog thyroglobulin. J. Clin. Endocr. 21: 1572, 1961. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Department of Medicine, Harvard Medical School and the Peter Bent Brigham Hospital, Boston, Mass.This study was supported in part by general research grant FR-05489-01, the U. S. Public Health Service, Washington, D. C., and in part by the Warner-Lambert Research Institute, the Research Division of Warner-Chilcott Laboratories, Morris Plains, N. J. Portions of this investigation were carried out in the Clinical Research Center of the Harvard Medical School and the Peter Bent Brigham Hospital under grant 2M01 -FR-31-06, the National Institutes of Health, Bethesda, Md.Dr. Wool is a Fellow under endocrine training grant T1-AM-5100, the U. S. Public Health Service.Preliminary data from this study were presented at the 47th Annual Session of the American College of Physicians, April 18, 1966, and at the Tenth Pan American Congress of Endocrinology, Mexico City, Mexico, October 15, 1965.Requests for reprints should be addressed to Herbert A. Selenkow, M.D., Peter Bent Brigham Hospital, 721 Huntington Ave., Boston, Mass. 02115. 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R. STEPHENSON, PH.D. 1 July 1967Volume 67, Issue 1Page: 90-99KeywordsEndocrinologyHospital medicineMedical servicesMetabolic disordersResearch grantsThyroidThyroid hormones Issue Published: 1 July 1967 PDF DownloadLoading ...