tbuckley/cabot-search huggingface dataset:
Postsurgical Staphylococcic Infections
Authors: Andre J. Nahmias
Journal: JAMA (1960)

Epidemics of staphylococcic infection in operating rooms have stimulated a critical interest in the origin and mode of transmission. The patience, ingenuity, and thoroughness required for the solution of such problems are illustrated by the account of Surgeon C, identified as the precipitating source of an epidemic. He was involved in 15 thoracic operations in which staphylococcic complications developed. Strains of staphylococci cultured from his face, nose, and hands were found, by antibiograms and phage typing, to be the same as those obtained from lesions in the infected patients. Pertinent questions are the reasons for Surgeon C's propensity for carrying epidemic strains and for his reversion, without treatment, to a negative carrier state. After a carrier has been identified and transferred, strict adherence to aseptic techniques will reduce the morbidity and mortality.
Some perturbations in medicine. An interview with Robert G. Petersdorf, MD
Authors: R. G. Petersdorf
Journal: JAMA (1982)

<h3>The Appearance of Full-time Professors</h3><h3>JAMA:</h3> How did US academic medicine develop? <h3>Petersdorf:</h3> I would like to trace the development of modern academic medicine in the United States from the time when full-time professors of medicine in this country began to appear: 1900 to 1930. The first departments of medicine with a full-time professor were established at The Johns Hopkins, Columbia, and, later, at Cornell and Barnes Hospitals, and, of course, the "Big Three in Boston": The Massachusetts General Hospital, the Peter Bent Brigham Hospital, and the Boston City Hospital. These early departments of medicine involved only a handful of people. There was usually one professor, and he had a number of assistants who would work primarily on his research interests and help to care for his patients. The major change that differentiated these professors from their predecessors in medical schools was that they were not primarily in private practice.
Recurrent Erythema Multiforme and Herpes Genitalis (Type 2)
Authors: Marie Britz
Journal: JAMA (1975)

IN 1972, MacDonald and Feiwel<sup>1</sup>cultured herpes simplex (HS) type 2 from the cutaneous bullae of a woman who had an erosive herpetic cervicitis, erythema multiforme (EM), and an elevated antibody titer to HS type 2. The purpose of this communication is to report what is, to our knowledge, the first case of recurring EM with mucous membrane involvement that was associated with culturally proved HS type 2 genital infection. Recognition of this clinical picture and familiarity with the diagnostic techniques of viral culture in these cases is imperative, as the incidence of EM associated with herpes is expected to parallel the rise in herpes genitalis.<sup>2</sup> <h3>Report of a Case</h3> A 17-year-old youth was admitted to the hospital in July 1973 complaining of photophobia, dysuria, and vesicoerosive lesions on the glans penis and coronal sulcus. On admission, he did not appear acutely ill. Examination disclosed erythematous papules and
New corn technology: scientists are all eyes and ears.
Authors: K Brown
Journal: Environmental Health Perspectives (1999)

Corn and other crops contaminated with the fungus Aspergillus flavus give off a carcinogenic by-product called aflatoxin, which is blamed for high rates of liver cancer in Asia and Africa, where rice and corn are food staples. In the United States, aflatoxin's major threat is to farm animals, which can get sick or even die from consuming too much of the toxin. Scientists are working on ways to keep the deadly toxin out of the food supply. Two techniques under development identify aflatoxin-tainted corn by using infrared light to elicit telltale sounds and light from contaminated kernels. Other scientists hope to protect corn from A. flavus in the first place by designing genetically engineered aflatoxin-resistant grain species and by working with drugs such as oltipraz that reportedly detoxify aflatoxin already in the body.
Ambulatory Centers Match Hospital Safety for Outpatient Colonoscopy, Study Says
Authors: Rebecca Voelker
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Natalizumab Therapy for Highly Active Pediatric Multiple Sclerosis
Authors: Barbara Kornek, Fahmy Aboul-Enein, Kevin Rostasy, Ruxandra-Iulia Milos, Irene Steiner, Johann Penzien, Kerstin Hellwig, Kalliopi Pitarokoili, Karin Storm van's Gravesande, Michael Karenfort, Astrid Blaschek, Andreas Meyer, Rainer Seidl, Diana Debelic, Karl Vass, Daniela Prayer, Wolfgang Kristoferitsch, Antonios Bayas
Journal: JAMA Neurology (2013)

<h3>Importance</h3>Given the high frequency of failure of first-line therapies, there is an urgent need for second-line treatment strategies for pediatric patients with multiple sclerosis (MS).<h3>Objective</h3>To report the use of natalizumab in pediatric MS. Natalizumab, a humanized monoclonal antibody targeting α4 integrin, is effective against active relapsing-remitting MS in adults.<h3>Design</h3>Retrospective study.<h3>Setting</h3>Eleven centers for neurology and pediatric neurology in Germany and Austria.<h3>Participants</h3>A total of 20 pediatric patients with MS who started treatment with natalizumab prior to 18 years of age. These patients underwent magnetic resonance imaging as clinically indicated, despite the fact that 19 of these 20 patients were undergoing first-line disease-modifying therapy. The mean (SD) age at initiation of natalizumab therapy was 16.7 (1.1) years, and the mean (SD) pretreatment period was 18 (10) months.<h3>Intervention</h3>Natalizumab, 300 mg every 4 weeks.<h3>Main Outcome Measures</h3>Annualized relapse rates, Expanded Disability Status Scale scores, number of new T2/fluid-attenuated inversion recovery lesions and contrast-enhancing lesions on magnetic resonance imaging, number of adverse events, the prevalence of neutralizing antibodies against natalizumab, and serum JC virus–antibody status.<h3>Results</h3>Treatment with natalizumab was associated with reductions in mean annualized relapse rates (3.7 without treatment vs 0.4 with treatment; P &lt; .001), median Expanded Disability Status Scale scores (2 without treatment vs 1 with treatment; P &lt; .02), and mean number of new T2/fluid-attenuated inversion recovery lesions per year (7.8 without treatment vs 0.5 with treatment; P &lt; .001). Two patients developed high-titer neutralizing antibodies against natalizumab and had to stop therapy. Adverse events included headaches, asthenia, infections, and hypersensitivity. Abnormal laboratory results were found for 8 patients. JC virus antibodies were found in 5 of 13 patients. After the discontinuation of natalizumab therapy, relapse activity occurred in 6 of 8 patients within 6 months.<h3>Conclusions and Relevance</h3>Our data indicate that natalizumab may be safe and effective against MS in pediatric patients with breakthrough disease.
P170Peripheral and coronary vasodilator response in chronic weary heart
Authors: L Ciobanu, M Popovici, E Panfile, V Cobet, V Ivanov, I Moraru, M Todiras
Journal: Cardiovascular Research (2014)

Aim: in vitro evaluation of the isolated aorta rings and coronary reactivity of isovolimic heart in fluorine induced on rat heart defeat (FHD).
Restoring invisible and abandoned trials: a call for people to publish the findings
Authors: P. Doshi, K. Dickersin, D. Healy, S. S. Vedula, T. Jefferson
Journal: BMJ (2013)

Unpublished and misreported studies make it difficult to determine the true value of a treatment. <b>Peter Doshi and colleagues</b> call for sponsors and investigators of abandoned studies to publish (or republish) and propose a system for independent publishing if sponsors fail to respond
Childhood Idiopathic Thrombocytopenic Purpura
Authors: Alton L. Lightsey
Journal: JAMA (1975)

Idiopathic thrombocytopenic purpura (ITP) in childhood is usually a benign, self-limited illness. Life-threatening complications, such as central nervous system (CNS) hemorrhage, occur in less than 1% of cases. We report a case in which the patient failed to respond to splenectomy and high-dose corticosteroid therapy. Immunosuppressive therapy with cyclophosphamide, vincristine sulfate, and corticosteroids in conjunction with frequent transfusions of platelets was associated with a complete remission that persisted after therapy was discontinued.
The Contributions of Authors
Authors: Drummond Rennie
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMPACT OF DRONEDARONE STARTED RAPIDLY AFTER AMIODARONE DISCONTINUATION
Authors: Peter R. Kowey, Bramah N. Singh, Stuart J. Connolly, Harry J. Crijns, Denis Roy, Alessandro Capucci, David Radzik, Etienne M. Aliot, Stefan H. Hohnloser
Journal: Journal of the American College of Cardiology (2010)
Assessment of respiratory function in patients with chronic obstructive airways disease.
Authors: I P Mungall, R Hainsworth
Journal: Thorax (1979)

The reproducibility of some respiratory function tests and a simple self-paced walking test were assessed in 13 patients with stable chronic obstructive airways disease by making observations on six occasions at two to three weekly intervals. The coefficients of variation of the various tests were as follows: forced expiratory volume in one second, +/- 14.8%; forced vital capacity, +/- 11.1%; transfer factor (single breath carbon monoxide), +/- 15%; total lung capacity, +/- 8.8% by helium dilution and +/- 8.3% by body plethysmography; increase in heart rate and minute ventilation for an increase in oxygen uptake of 0.5 1 min-1, +/- 19.4% and +/- 16.3%; distance covered in a 12-minute walking test, +/- 8.2%. The 12-minute distance increased significantly over the first three studies. The considerable variations in the result of these tests in subjects with apparently stable clinical states and without changes in treatment should be considered when assessing the results of changes in treatment.
Bardet–Biedl syndrome highlights the major role of the primary cilium in efficient water reabsorption
Authors: Vincent Marion, Dominique Schlicht, Anaïs Mockel, Sophie Caillard, Olivier Imhoff, Corinne Stoetzel, Paul van Dijk, Christian Brandt, Bruno Moulin, Hélène Dollfus
Journal: Kidney International (2011)
Cinefluorographic Study of Hyperextension of the Neck and Upper Airway Patency
Authors: David G. Greene
Journal: JAMA (1961)

Cinefluorographic techniques were used in order to locate the sites of obstruction in the upper airways when artificial respiration was given by mouth-to-mouth and mouth-to-nose methods. In 15 adult volunteer subjects anesthetized to apnea 3 sites of obstruction were observed with the subject's head in the neutral position. Two were areas of contact of the pharyngeal wall with (1) the soft palate and (2) the base of the tongue; the third was at the lips. Obstruction at (1) and (2) was relieved when the head was moved back into the extended position by the two-handed hyperextension maneuver. This head-tilt maneuver is a reliable, simple, versatile method of clearing the upper airways for mouth-to-mouth and mouth-to-nose artificial respiration.
Criteria and Recommendations for Vitamin C Intake
Authors: Mark Levine
Journal: JAMA (1999)

Recommendations for vitamin C intake are under revision by the Food and Nutrition Board of the National Academy of Sciences. Since 1989 when the last recommended dietary allowance (RDA) of 60 mg was published, extensive biochemical, molecular, epidemiologic, and clinical data have become available. New recommendations can be based on the following 9 criteria: dietary availability, steady-state concentrations in plasma in relationship to dose, steady-state concentrations in tissues in relationship to dose, bioavailability, urine excretion, adverse effects, biochemical and molecular function in relationship to vitamin concentration, direct beneficial effects and epidemiologic observations in relationship to dose, and prevention of deficiency. We applied these criteria to the Food and Nutrition Board's new guidelines, the Dietary Reference Intakes, which include 4 reference values. The estimated average requirement (EAR) is the amount of nutrient estimated to meet the requirement of half the healthy individuals in a life-stage and gender group. Based on an EAR of 100 mg/d of vitamin C, the RDA is proposed to be 120 mg/d. If the EAR cannot be determined, an adequate intake (AI) amount is recommended instead of an RDA. The AI was estimated to be either 200 mg/d from 5 servings of fruits and vegetables or 100 mg/d of vitamin C to prevent deficiency with a margin of safety. The final classification, the tolerable upper intake level, is the highest daily level of nutrient intake that does not pose risk or adverse health effects to almost all individuals in the population. This amount is proposed to be less than 1 g of vitamin C daily. Physicians can tell patients that 5 servings of fruits and vegetables per day may be beneficial in preventing cancer and providing sufficient vitamin C intake for healthy people, and that 1 g or more of vitamin C may have adverse consequences in some people.
Response to "Mandatory Anesthesia”
Authors: Derek Bond Rosner
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Identification of the plasminogen activator secreted by human fibroblasts
Authors: S.A. CEDERHOLM-WILLIAMS, N.W. PORTER
Journal: British Journal of Dermatology (1984)

Plasminogen activator was partially purified from cultured human fibroblasts. The enzyme binds to fibrin, has a molecular weight of 68,000 and is antigenically identical to human uterine tissue plasminogen activator.
"MEDICAL AID IN HASTE"
Authors: Boris J. Sohn
Journal: JAMA (1924)

<h3>To the Editor:</h3> —In regard to the communication appearing inThe Journal, Dec. 29, 1923, by Dr. James Brown Thornton, relative to the automobile plates that now adorn the automobiles of the Osteopaths in Boston, I wish to state that our city of Norwich, Conn., has long been blessed with similar "insignia" on the car of a chiropractor. It consists of a ring about 3 inches in diameter, enameled red, the hollow of which is occupied by a cross, enameled white. The ring, or circle, which is prominently displayed on both the front and the rear of the machine, shows on its upper part the name, in full, of the "practitioner"; the lower part, the word "chiropractor." What's next?
Goals for The Journal
Authors: George D. Lundberg
Journal: JAMA (1982)

Every organization needs goals and objectives. Without such, the organization may be without defined purpose, and it cannot set priorities or measure progress. A goal is an end toward which effort is directed. In modern management usage, a goal is often ideal, far-reaching, long-term, and strategic and may be ultimately unattainable. Objectives are specific positions that one desires to attain. An objective is finite and limited and may describe various stages, such as preliminary, intermediate, partial, or terminal. Objectives often are stepping-stones toward a goal.  In establishing goals, it is wise to involve those persons whose energies or resources will be required to meet them. When it was decided to set written goals forThe Journal, we asked members of the senior editorial staff to make proposals. These suggested goals totaled 44. They were condensed into a group of eight, expanded to a more comprehensive 13, reedited, and voted on
Dialysis, Old Age, and Rehabilitation
Authors: Christopher R. Blagg
Journal: JAMA (1994)

Health care reform and an aging population have rekindled concerns about treatment of the elderly by high-cost technology, so it is timely that two articles in this issue ofThe JOURNALdiscuss elderly dialysis patients. Byrne et al<sup>1</sup>report survival with chronic dialysis in the elderly and the relatively poor life expectancy compared with age-matched peers in the general population, especially when end-stage renal disease (ESRD) is caused by diabetes. Ifudu et al<sup>2</sup>describe "dismal" rehabilitation in elderly inner-city hemodialysis patients; again, diabetics fared less well than nondiabetics. Despite the authors' disclaimers, both articles may well be used by "those who wish to institute age-based rationing of hemodialysis."
Intracardiac Myxomas with Report of Two Unusual Cases and Successful Removal
Authors: JOHN T. DIFFERDING, RICHARD E. GARDNER, BENSON B. ROE
Journal: Circulation (1961)

A comprehensive review of the various aspects of intracardiac myxomas is presented. Two unusual cases are illustrative of many of the problems encountered. Of particular interest are the successful surgical removals of the myxomas in both cases.
Infection with parvovirus during pregnancy.
Authors: E P Wright, A J Dyson, A Alaily
Journal: BMJ (1985)

extra cost of performing tests on an emergency basis.We consider that the incremental cost of such tests should be passed on to the requesting clinician.In this way there would be greater awareness of the additional costs entailed in performing such emergency tests.Clinicians would then be encouraged to judge whether a request could be delayed and incorporated into the routine work of the laboratory concerned.
Centers needed to study women's environmental health.
Authors: M C Hatch
Journal: Environmental Health Perspectives (2000)

The view of women as primarily fecund beings goes back to prehistory, where it is expressed in the well-known series of Venuses--stone figures of women with enlarged breasts, who are often represented as pregnant. Although the Venus figures date from the late Paleolithic era, this view of women did not change much in the next 20,000 years. With the approaching millennium, however, the field of health research has begun to consider women apart from their children or prospective progeny. Reflecting this shift in viewpoint, funds for research on the environmental health of women have now become available. However, no coordinated program has been launched on the scale of the newly established Centers for Children's Environmental Health and Disease Prevention Research (1). Should women, like children, be the focus of a concerted research effort?
High affinity membrane receptors in cultured human keratinocytes I. The β-adrenergic receptors
Authors: J. GAZITH, U. REICHERT
Journal: British Journal of Dermatology (1982)

Journal Article High affinity membrane receptors in cultured human keratinocytes I. The β‐adrenergic receptors Get access J. GAZITH, J. GAZITH Centre international de Recherches Dermatologiques, Valbonne, France Search for other works by this author on: Oxford Academic Google Scholar U. REICHERT U. REICHERT Centre international de Recherches Dermatologiques, Valbonne, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue s23, 1 November 1982, Pages 125–133, https://doi.org/10.1111/j.1365-2133.1982.tb01044.x Published: 01 November 1982
Markets cannot ration care equitably and efficiently
Authors: D. McLernon-Billows
Journal: BMJ (2012)

Initially, it was claimed we needed reform to reverse the UK’s flagging health outcomes.1 Enthusiasm for this argument has waned as claims of poor patient satisfaction, cancer outcomes, and heart disease outcomes have been shown to be false.2

Cost efficiency has been cited as a key objective, but this is contradicted by government action. …