tbuckley/cabot-search huggingface dataset:
Selenomethionine Se 75 Scan for Thymoma
Authors: James F. Toole
Journal: JAMA (1966)

ABSTRACT BETWEEN 15% and 30% of patients with myasthenia gravis are said to have thymic tumors.1 However, roentgenographic delineation of thymomas is difficult because the x-ray shadow of the tumor often lies hidden within those cast by other mediastinal structures. Consequently, gas contrast methods such as pneumomediastinography have been used to outline mediastinal contents. However the technique is hazardous for seriously ill myasthenic patients and the results can be misleading. An atraumatic, rapid way to circumvent this difficulty may be radioisotopic scanning of the mediastinum with selenomethionine Se 75. The details of what may be a new method for detection of thymic tumors are summarized below.Report of a Case The patient (NCBH 43 02 80), a 63-year-old man, began to experience intermittent diplopia in September 1964. Over the ensuing months his double vision became constant and he gradually developed bilateral eyelid ptosis. Despite the use of near toxic doses
Echocardiographic diastolic abnormalities of the left ventricle in inflammatory joint disease.
Authors: I F Rowe, D G Gibson, A C Keat, D A Brewerton
Journal: Annals of the Rheumatic Diseases (1991)

Echocardiographic early diastolic abnormalities have been shown recently in 50% of men with ankylosing spondylitis. Similar techniques were used to investigate subjects with rheumatoid arthritis and psoriatic arthritis with or without spondylitis. These subjects had no clinical, radiographic, or electrocardiographic evidence of cardiac or respiratory disease. Echocardiographic abnormalities seen resembled those of ankylosing spondylitis in that the interval between minimum left ventricular dimension and mitral valve opening was prolonged in 12 of 22 subjects with rheumatoid arthritis and in seven of 11 subjects with psoriatic arthritis. Isovolumic relaxation time was significantly prolonged in four subjects with rheumatoid arthritis and one with psoriatic arthritis. Unlike ankylosing spondylitis, however, there was consistent reduction in peak rate of left ventricular dimension increase in subjects with rheumatoid arthritis and psoriatic arthritis. In addition, the dimension increase during atrial systole was greater than normal in nine subjects with rheumatoid arthritis and two with psoriatic arthritis. The most likely cause of these abnormalities is increased connective tissue deposition in the myocardium.
Subcortical Visual Shell Nuclei Targeted by ipRGCs Develop from a Sox14+-GABAergic Progenitor and Require Sox14 to Regulate Daily Activity Rhythms
Authors: Alessio Delogu, Katherine Sellers, Laskaro Zagoraiou, Alina Bocianowska-Zbrog, Shyamali Mandal, Jordi Guimera, John L.R. Rubenstein, David Sugden, Thomas Jessell, Andrew Lumsden
Journal: Neuron (2012)
KLF6 IVS1 -27G&gt;A Variant and the Risk of Prostate Cancer in Finland
Authors: Eija H. Seppälä, Ville Autio, Priya Duggal, Tarja Ikonen, Ulf-Håkan Stenman, Anssi Auvinen, Joan E. Bailey-Wilson, Teuvo L.J. Tammela, Johanna Schleutker
Journal: European Urology (2006)
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
Authors: Siyuan Zhang, Wen-Chien Huang, Ping Li, Hua Guo, Say-Bee Poh, Samuel W Brady, Yan Xiong, Ling-Ming Tseng, Shau-Hsuan Li, Zhaoxi Ding, Aysegul A Sahin, Francisco J Esteva, Gabriel N Hortobagyi, Dihua Yu
Journal: Nature Medicine (2011)
Relationship between the 12-lead electrocardiogram during ventricular tachycardia and endocardial site of origin in patients with coronary artery disease.
Authors: J M Miller, F E Marchlinski, A E Buxton, M E Josephson
Journal: Circulation (1988)

Previous studies in patients with sustained ventricular tachycardia (VT) have demonstrated the efficacy of surgical and catheter-mediated ablative procedures based on activation mapping during VT. Since extensive preoperative or intraoperative mapping may be impractical due to time constraints or patient intolerance, we sought to define characteristics of the 12-lead electrocardiogram (ECG) during VT that could suggest a particular endocardial region of origin and thus facilitate mapping studies. Endocardial mapping was performed during 182 VTs in 108 patients with prior myocardial infarction of either the anterior or inferior wall. Endocardial sites of origin (sites from which greater than or equal to 40 msec of presystolic electrical activity was consistently recorded) were identified with use of catheter (154 VTs) or intraoperative (85 VTs) activation mapping (both methods used in 57 Vts). Twelve-lead ECGs obtained during these VTs were characterized by four features: location of infarction, bundle branch block type configuration, quadrant of QRS axis, and precordial R wave progression pattern. A specific combination of these four features was associated with a particular endocardial region containing the mapped site of origin in 87 VTs (48% of total). An association (greater than or equal to 70% positive predictive accuracy) was more likely to be found in the presence of left, as opposed to right, bundle branch block type patterns (53/73 [73%] vs 34/109 [31%]; p less than .001) and in the presence of VT related to inferior, as opposed to anterior, infarction (40/54 [74%] vs 47/128 [37%]; p less than .001).(ABSTRACT TRUNCATED AT 250 WORDS)
Bring back absolute accountability
Authors: N. Sellwood
Journal: BMJ (2013)

<h3>Objective</h3> To evaluate the impact on structural lesions observed on MRI in the sacroiliac joints (SIJ) at 12 weeks in patients with non-radiographic axial spondyloarthritis (nr-axSpA) receiving etanercept or placebo in EMBARK (Effect of Etanercept on Symptoms and Objective Inflammation in nr-axSpA, a 104 week study). <h3>Methods</h3> Patients were randomised to double-blind etanercept 50 mg/week or placebo for 12 weeks. Structural lesions at baseline and 12 weeks were scored by two independent readers using the Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ structural score (SSS) on T1-weighted MRI. Change in SPARCC SSS and correlation with improvement in clinical outcomes was evaluated. <h3>Results</h3> MRI scans from 185 patients (etanercept, n=88; placebo, n=97) were reviewed. At baseline, there were no significant differences in mean SPARCC SSS between etanercept and placebo. From baseline to 12 weeks, change in mean SPARCC SSS was significantly greater for etanercept than placebo for erosion (–0.57 vs –0.08, respectively, adjusted p value=0.017) and backfill (0.36 vs 0.06, adjusted p value=0.022). A treatment difference was also present for the subgroup of patients with SIJ inflammation on MRI (SPARCC bone marrow oedema ≥2): erosion: –0.81 versus –0.13 for etanercept versus placebo, respectively, p=0.007; backfill: 0.48 versus 0.08, respectively, p=0.032. Decrease in erosion and increase in backfill correlated with improvement in more clinical outcomes for etanercept than placebo. <h3>Conclusion</h3> Treatment with etanercept was associated with significantly greater reduction in erosions and increase in backfill at 12 weeks compared with placebo, consistent with a very early reparative response to antitumour necrosis factor therapy. The impact on disease progression in spondyloarthritis should be studied further. <h3>Trial registration number</h3> NCT01258738; Post-results.
Serial Electrocardiographic Findings in a Prospective Epidemiological Study
Authors: LEON D. OSTRANDER
Journal: Circulation (1966)

The prevalence of classified electrocardiographic items among the adult population of Tecumseh, Michigan, during two examinations approximately 4 years apart is reported. Changes in the prevalence rates of certain items are probably due to reader differences, the effect of prior ingestion of glucose in the first series of examinations, and possibly the treatment of abnormalities detected during the first examinations. Among the cohort of 3,745 persons who had classified electrocardiograms on both examinations, the Q and QS items were relatively stable, the more marked ST and T items were less stable, and the minor ST or T classifications were extremely variable. Still, 31% of persons whose second electrocardiogram revealed codable Q or QS items for the first time had classified ST-segment or T-wave items in their previous electrocardiogram and another 9% had nonspecific QRS abnormalities, either high amplitude R waves or left axis deviation. The Minnesota code is a useful system for the classification of large numbers of electrocardiograms, but for accurate identification of new events, tracings exhibiting category I, IV, or V items must be examined serially.
In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer
Authors: Yun Mi Kang, Gyeong Hae Kim, Jae Il Kim, Da Yeon Kim, Bit Na Lee, So Mi Yoon, Jae Ho Kim, Moon Suk Kim
Journal: Biomaterials (2011)
Subclinical Lead Exposure in Philadelphia Schoolchildren
Authors: Herbert L. Needleman, Isobel Davidson, Edward M. Sewell, Irving M. Shapiro
Journal: New England Journal of Medicine (1974)

Dentine lead levels were measured from shed deciduous teeth of 761 Philadelphia schoolchildren with no prior history of lead poisoning and residing in two school districts, one considered high risk for lead exposure, and one considered low risk. Black children in public schools from areas of deteriorated housing had marked elevations of dentine lead (mean of 198 μg per gram, in 174 children), with 20 per cent of the children having levels in the range associated with toxicity. White children from newer housing had the lowest levels (mean of 41.7μg per gram, 304 children), but a group of white children from intact housing living near and attending school adjacent to a major lead processor also had elevations of dentine lead (mean of 136 μg per gram, 71 determinations). Lead exposure as defined by dentine lead levels is more serious and widespread than previously acknowledged, and extends to groups other than those traditionally accepted as at risk. (N Engl J Med 290:245–248, 1974).
CREATION OF A SURGICAL FONTAN ANIMAL MODEL AND THE USE OF A VENTRICULAR ASSIST DEVICE TO RESTORE CARDIAC OUTPUT
Authors: Gwendolyn R. Derk, Hillel Laks, Reshma Biniwale, Sanjeet Patel, Kim DeLaCruz, Einat Mazor, Ryan Williams, John Valdovinos, Daniel Levi, Jamil Aboulhosn
Journal: Journal of the American College of Cardiology (2014)
Using Internet Technology to Deliver a Behavioral Weight Loss Program
Authors: Deborah F. Tate
Journal: JAMA (2001)

ContextRapid increases in access to the Internet have made it a viable mode for public health intervention. No controlled studies have evaluated this resource for weight loss.ObjectiveTo determine whether a structured Internet behavioral weight loss program produces greater initial weight loss and changes in waist circumference than a weight loss education Web site.DesignRandomized, controlled trial conducted from April to December 1999.Setting and ParticipantsNinety-one healthy, overweight adult hospital employees aged 18 to 60 years with a body mass index of 25 to 36 kg/m2. Analyses were performed for the 65 who had complete follow-up data.InterventionsParticipants were randomly assigned to a 6-month weight loss program of either Internet education (education; n = 32 with complete data) or Internet behavior therapy (behavior therapy; n = 33 with complete data). All participants were given 1 face-to-face group weight loss session and access to a Web site with organized links to Internet weight loss resources. Participants in the behavior therapy group received additional behavioral procedures, including a sequence of 24 weekly behavioral lessons via e-mail, weekly online submission of self-monitoring diaries with individualized therapist feedback via e-mail, and an online bulletin board.Main Outcome MeasuresBody weight and waist circumference, measured at 0, 3, and 6 months, compared the 2 intervention groups.ResultsRepeated-measures analyses showed that the behavior therapy group lost more weight than the education group (P = .005). The behavior therapy group lost a mean (SD) of 4.0 (2.8) kg by 3 months and 4.1 (4.5) kg by 6 months. Weight loss in the education group was 1.7 (2.7) kg at 3 months and 1.6 (3.3) kg by 6 months. More participants in the behavior therapy than education group achieved the 5% weight loss goal (45% vs 22%; P = .05) by 6 months. Changes in waist circumference were also greater in the behavior therapy group than in the education group at both 3 months (P = .001) and 6 months (P = .005).ConclusionsParticipants who were given a structured behavioral treatment program with weekly contact and individualized feedback had better weight loss compared with those given links to educational Web sites. Thus, the Internet and e-mail appear to be viable methods for delivery of structured behavioral weight loss programs.
Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart Failure
Authors: Hanqiao Wang, John D. Parker, Gary E. Newton, John S. Floras, Susanna Mak, Kuo-Liang Chiu, Pimon Ruttanaumpawan, George Tomlinson, T. Douglas Bradley
Journal: Journal of the American College of Cardiology (2007)
Impressions of Postgraduate Education in America
Authors: C. F. Hawkins
Journal: BMJ (1952)

One of the joys of a travelling physician is the great number of rounds, grand rounds, meetings, seminars, forums, and clinico-pathological and departmental con- ferences that go on in every medical centre.These are full of the enthusiasm of the New World, and may begin at 8 a.m., an hour when many doctors start their work.The discussions are generally excellent and the uninhibited exchange of knowledge stimulating and instruc- tive, particularly if guided by a good chairman.Perhaps the Americans are more extraverted than we are, or their exhibitionism more developed, but they do not hesitate to talk.This conference habit, apart from the value of the hospital staff meeting at frequent intervals, seemed a sure way of keeping up to date on medical progress, and, perhaps, a pleasant substitute for much reading on one's own.
Smoking continues to fall among US teens
Authors: Scott Gottlieb
Journal: BMJ (2004)

The percentage of US teenagers who smoke fell to 22% in 2003—the lowest level since records began in 1991, a new survey shows ( Morbidity and Mortality Weekly Report 2004;53:499-502). Experts are attributing the findings to the rising cost of cigarettes.

At about $4 (£2.20; €3.30) for a pack of cigarettes, teenagers would rather spend their money on new clothes, a movie, or eating out. High school students are also becoming more conscientious about their health and less intrigued by lighting up, finds the …
Long-Term Lisinopril Therapy Reduces Exercise-Induced Albuminuria in Normoalbuminuric Normotensive IDDM Patients
Authors: Juha A Tuominen, Pertti Ebeling, Veikko A Koivisto
Journal: Diabetes Care (1998)

OBJECTIVE To study the effect of lisinopril on the exercise-induced urinary albumin excretion rate. RESEARCH DESIGN AND METHODS A total of 26 IDDM patients with normoalbuminuria were randomized into two groups, with one group receiving placebo (n = 13, age 36 ± 3 years, BMI 24.5 ± 1.1 kg/m2) and the other group receiving an average of 15 mg lisinopril daily (n = 13, age 34 ± 2 years, BMI 24.4 ± 0.9 kg/m2). Overnight and exercise-induced urinary albumin excretion rate was measured at baseline and after 1 and 2 years of treatment. Two patients in the placebo group and none in the lisinopril group developed microalbuminuria. RESULTS In the lisinopril group, the exercise-induced urinary albumin excretion rate diminished 46% after the 1st year (P = 0.059) and 66% (P &amp;lt; 0.01) after the 2nd year. However, it remained unchanged in the control group. Systolic blood pressure (sBP) and diastolic blood pressure (dBP) were similar at baseline and after 1 year, but at 2 years, sBP was 13 mmHg lower (P = 0.03) and dBP was 9 mmHg lower (P = 0.052) in the lisinopril group as compared with the control group. The dBP decreased significantly at 1 and 2 years in the lisinopril group, while there was no significant change in the sBP. In the whole group at baseline, the overnight albumin excretion rate correlated with HbA1c (r = 0.50, P &amp;lt; 0.01) and the duration of diabetes (r = 0.39, P &amp;lt; 0.05), and sBP correlated with both the overnight (r = 0.42, P &amp;lt; 0.05) and the exercise-induced (r = 0.48, P &amp;lt; 0.05) albumin excretion rate. CONCLUSIONS Glycemic control and blood pressure are directly related to the overnight albumin excretion rate also in normotensive normoalbuminuric IDDM patients. Lisinopril treatment reduces the exercise-induced urinary albumin excretion rate in such patients. These data suggest a protective effect of lisinopril against the development of microalbuminuria.
Laser treatment of port-wine stains
Authors: R.W. Gange, R.R. Anderson, E. Gonzalez
Journal: British Journal of Dermatology (1988)

Journal Article Laser treatment of port‐wine stains Get access R.W. Gange, R.W. Gange Wellman Laboratory Massachusetts General Hospital Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar R.R. Anderson, R.R. Anderson Wellman Laboratory Massachusetts General Hospital Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar E. Gonzalez E. Gonzalez Wellman Laboratory Massachusetts General Hospital Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 119, Issue 1, 1 July 1988, Pages 131–132, https://doi.org/10.1111/j.1365-2133.1988.tb07118.x Published: 01 July 1988
Treatment of chronic hepatitis C virus genotype 1 with peginterferon, ribavirin, and epoetin alpha
Authors: Mitchell L. Shiffman, Jennifer Salvatore, Sarah Hubbard, Angie Price, Richard K. Sterling, R. Todd Stravitz, Velimir A. Luketic, Arun J. Sanyal
Journal: Hepatology (2007)

Successful treatment of chronic HCV with peginterferon (PEGIFN) and ribavirin (RVN) is often limited by anemia. We performed the present study to determine if utilizing epoetin alpha (EPO) with or without a higher dose of RVN could enhance sustained virologic response (SVR). We randomized 150 treatment-naive patients with chronic HCV genotype 1 into 3 treatment groups: (1) PEGIFN alpha-2b (1.5 microg/kg/week) + weight-based RVN (WBR) 13.3 mg/kg/day (800 to 1400 mg/day); (2) PEGIFN alpha-2b + WBRVN + EPO (40,000 U/week); or (3) PEGIFN alpha-2b + higher dose WBR 15.2 mg/kg/day (1000 to 1600 mg/day) + EPO. We initiated EPO at the onset of therapy to maintain the hemoglobin between 12 and 15 g/dL. When required, we reduced RVN by 200-mg steps. African Americans compose 36% of the population. A significantly smaller percentage of group 2 patients had a decline in hemoglobin to less than 10 g/dL (9% versus 34%; P < 0.05) and required that the RVN dose be reduced (10% versus 40%; P < 0.05) compared to group 1 patients. Despite this, SVR was similar in these groups (19% to 29%). SVR was significantly greater (P < 0.05) in group 3 patients (49%). This resulted from a significant decline (P < 0.05) in relapse rate; only 8% versus 38% for groups 1 and 2.We conclude that using EPO in all subjects at the initiation of PEGIFN and RVN treatment will not enhance SVR given the same starting dose of RVN. In contrast, a higher starting dose of RVN was associated with a lower relapse rate and higher rate of SVR.
Diabetes Control and Neuropathy
Authors: STEVEN H. HOROWITZ
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 November 1981Diabetes Control and NeuropathySTEVEN H. HOROWITZ, M.D.STEVEN H. HOROWITZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-5-654 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Graf and associates (1) conclude from measurements of nerve conduction velocities that diabetic control improves nerve function and thereby support the hypothesis that diabetic neuropathy has a metabolic component. Although these conclusions may be correct, they are based on inadequate and misleading data and represent a gross misuse of statistics.Of five motor and sensory velocities studied, one (median motor) showed statistical improvement, 3.7 m/s (8% of the pretreatment value), after 12 months of therapy. Practically, repeated differences of less than 5.0 m/s on the same nerve are considered to be within the test's range of variability....References1. GRAFHALTERPFEIFERHALARBROZOVICHPORTE RJMEFD. Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects. Ann Intern Med. 1981;94:307-11. LinkGoogle Scholar2. MCQUILLENGORIN MF. Serial ulnar nerve conduction velocity measurements in normal subjects. J Neurol Neurosurg Psychol. 1969;32:144-8. CrossrefMedlineGoogle Scholar3. HOROWITZGINSBERG-FELLNER SF. Ischemia and sensory nerve conduction in diabetes mellitus. Neurology. 1979;29:695-704. CrossrefMedlineGoogle Scholar4. GREENEBROWNBRAUNSTEINSCHWARTZASBURYWINEGRAD DMSSAA. Comparison of clinical course and sequential electrophysiological tests in diabetics with symptomatic polyneuropathy and its implications for clinical trial. Diabetes. 1981;30:139-47. CrossrefMedlineGoogle Scholar5. HUTH E. The ethics of medical publishing: prior publication and full disclosure by authors. Ann Intern Med. 1981;94:401-2. Editorial. LinkGoogle Scholar6. PORTEGRAFHALTERPFEIFERHALAR DPJME. Diabetic neuropathy and plasma glucose control. Am J Med. 1981;70:195-200. CrossrefMedlineGoogle Scholar1. HALARVENKATESH EM. Nerve conduction velocity measurements: improved accuracy using superimposed response waves. Arch Phys Med Rehabil. 1976;57:451-7. MedlineGoogle Scholar2. WARD J. Diabetic neuropathy. Clin Endocrinol Metab. 1972;1:809-27. CrossrefMedlineGoogle Scholar3. GREGERSEN G. Vibratory perception threshold and motor conduction velocity in diabetics and non-diabetics. Acta Med Scand. 1968;183:61. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEVEN H. HOROWITZ, M.D.Affiliations: Long Island Jewish—Hillside Medical Center New Hyde Park, NY 11042 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1981Volume 95, Issue 5Page: 654-655KeywordsNervesNeuropathyStatistical data ePublished: 1 December 2008 Issue Published: 1 November 1981 PDF downloadLoading ...