tbuckley/cabot-search huggingface dataset:
Activities of the National Institutes of Health relating to energy efficiency and pollution prevention.
Authors: S A Ficca, Y D Chyun, M Ebrahimi, F Kutlak, F Memarzadeh
Journal: Environmental Health Perspectives (2000)

The National Institutes of Health (NIH) is one of the world's premier biomedical research centers. Although NIH owns and operates more than 1,300 acres and 197 buildings across the country, the main campus is in Bethesda, Maryland. This campus consists of over 312 acres and 75 laboratories and other buildings, which consume vast amounts of energy. Aware of the NIH role in setting biomedical research agendas and priorities, its administrators strive to set good examples in energy efficiency and pollution prevention. Three current projects are presented as
TCT-262 Comparison of Target Lesion Revascularization in Patients with Renal Insufficiency after Sirolimus-eluting Stent and Everolimus-eluting Stent Implantation: Three-year Outcomes from Single-center Retrospective Study
Authors: Suguru Otsuru, Kazushige Kadota, Shunsuke Kubo, Yusuke Hyodo, Tahei Ichinohe, Daiji Hasegawa, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2014)
Effect of endoscopic augmentation of the lower oesophageal sphincter (Gatekeeper reflux repair system) on intraoesophageal dynamic characteristics of acid reflux
Authors: M Cicala
Journal: Gut (2005)

Improvements in symptoms following endoscopic procedures for gastro-oesophageal reflux disease (GORD) are seldom supported by normalisation of acid exposure time at the distal oesophagus. However, the distribution of gastric acid within the proximal oesophagus is a main determinant of symptom generation in GORD patients. In this study, our aim was to assess the effect of endoscopic insertion of hydrogel expandable prostheses into the oesophageal submucosa on spatiotemporal characteristics of gastro-oesophageal reflux.
Visualization of the distance between perfusion and anoxia along an ischemic border.
Authors: M B Simson, W Harden, C Barlow, A H Harken
Journal: Circulation (1979)

The distance between perfusion and anoxia was measured on the border of an experimental ischemic area in the rabbit heart. Reduced nicotinamide adenine dinucleotide (NADH) fluorescence photography was used to detect myocardial anoxia. Fluorescein angiography marked areas of myocardial perfusion. The hearts were isolated, perfused with a hemoglobin-free solution and performed no external work. In all hearts there was a narrow band between areas of perfusion and anoxia that measured 329 +/- 42 mu (mean +/- SD). The transition from minimal to full NADH fluorescence was abrupt, less than 80 mu. We conclude that the normoxic/anoxic transition is sharp, and the gap between perfusion and anoxia is narrow along an ischemic border in the isolated heart performing no external work. These data suggest that in the vivo working heart the gap between perfusion and anoxia would be even narrower.
Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1
Authors: Mirjam E. Meltzer, Ton Lisman, Philip G. de Groot, Joost C. M. Meijers, Saskia le Cessie, Carine J. M. Doggen, Frits R. Rosendaal
Journal: Blood (2010)
Expansion of acute myocardial infarction: an experimental study.
Authors: J S Hochman, B H Bulkley
Journal: Circulation (1982)

Expansion (regional dilatation and thinning) of acutely infarcted myocardium in man has been shown to correlate with overall cardiac dilatation and rupture. We studied gross and histopathologic features and the time course of expansion in rats. Infarcts were produced in 84 rats by ligation of the left coronary artery and studied at 1, 2, 3, 4, 5 and 7 days. All hearts were prepared by potassium diastolic arrest, gel distention and fixation. Expansion was graded 0 to 4+ : 1+, mild thinning of infarcted wall; 2+, mild thinning and dilatation; 3+, moderate thinning and dilatation; and 4+, marked thinning and dilatation. There were 80 transmural infarcts, and 66% showed expansion; 36 of 80 (45%) were graded 1-2+ and 17 of 80 (21%) 3-4+. None of the four exclusively nontransmural infarcts showed expansion. Expansion was present in 61% of transmural infarcts at 1-2 days, in 65% at 3-4 days and in 80% at 5-7 days. The percentage of rats with severe (3-4+) expansion increased markedly over this period, from 0% at 1-2 days to 23% at 3-4 days to 65% at 5-7 days. Histopathologic infarct evolution was roughly twice as rapid as that of humans; 5-7 day-old infarcts showed well-developed granulation tissue. Thus, expansion can be produced in an animal model. A critical infarct size of 17% appeared necessary for significant (greater than 1+) expansion, and the degree of expansion correlated with infarct size. Although this phenomenon begins early after infarction, its extent progresses over days, making interventions to interrupt its development feasible.
Five adults with mild sickle cell anemia share a β<sup>s</sup> chromosome with the same haplotype
Authors: I. Bakioglu, Y. Hattori, A. Kutlar, C. Mathew, T. H. J. Huisman
Journal: American Journal of Hematology (1985)

Abstract Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their (β s chromosomes. One subject had an α‐thalassemia (–α/–α). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the β s # 31 chromosome promotes the synthesis of γ chains.
Academic Family Medicine-Reply
Authors: Edmund D. Pellegrino
Journal: JAMA (1978)

Dr Friedman's comments on my article are, as he promised, both practical and pertinent. They come, as I know personally, from many years of devotion to the teaching and practice of family medicine, and so are most welcome. Happily, too, Friedman supplements several points I had to make only indirectly for the sake of brevity.  Friedman's comments on the unfriendly environment of the university hospital are especially telling. This is a complaint heard all too frequently. It poses a serious and unmet challenge to those clinicians concerned about teaching the caring obligations of the physician. The legitimate needs of teaching and research unquestionably complicate the care of patients. But they cannot justify insensitivity in the place where nurses and physicians receive the first and often lasting impressions of how to care for those in need of their help.  Equally cogent are Friedman's observations about the unsatisfactory care of
In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells
Authors: Luca Biasco, Serena Scala, Luca Basso Ricci, Francesca Dionisio, Cristina Baricordi, Andrea Calabria, Stefania Giannelli, Nicoletta Cieri, Federica Barzaghi, Roberta Pajno, Hamoud Al-Mousa, Alessia Scarselli, Caterina Cancrini, Claudio Bordignon, Maria Grazia Roncarolo, Eugenio Montini, Chiara Bonini, Alessandro Aiuti
Journal: Science Translational Medicine (2015)

A definitive understanding of survival and differentiation potential in humans of T cell subpopulations is of paramount importance for the development of effective T cell therapies. In particular, uncovering the dynamics in vivo in humans of the recently described T memory stem cells (TSCM) would be crucial for therapeutic approaches that aim at taking advantage of a stable cellular vehicle with precursor potential. We exploited data derived from two gene therapy clinical trials for an inherited immunodeficiency, using either retrovirally engineered hematopoietic stem cells or mature lymphocytes to trace individual T cell clones directly in vivo in humans. We compared healthy donors and bone marrow-transplanted patients, studied long-term in vivo T cell composition under different clinical conditions, and specifically examined TSCM contribution according to age, conditioning regimen, disease background, cell source, long-term reconstitution, and ex vivo gene correction processing. High-throughput sequencing of retroviral vector integration sites (ISs) allowed tracing the fate of more than 1700 individual T cell clones in gene therapy patients after infusion of gene-corrected hematopoietic stem cells or mature lymphocytes. We shed light on long-term in vivo clonal relationships among different T cell subtypes, and we unveiled that TSCM are able to persist and to preserve their precursor potential in humans for up to 12 years after infusion of gene-corrected lymphocytes. Overall, this work provides high-resolution tracking of T cell fate and activity and validates, in humans, the safe and functional decade-long survival of engineered TSCM, paving the way for their future application in clinical settings.
Occult Splenic Rupture
Authors: Ronald P. Fischer
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The recent article on occult rupture of the spleen (236:2884, 1976) perpetuates the incorrect clinical lore that 15% of patients with splenic trauma have delayed splenic rupture. The authors state that "delayed splenic rupture occurs when bleeding recurs in the subcapsular hematoma, producing increased pressure and disrupting an already thinned, stretched capsule." The published reports of Olsen<sup>1</sup>and of Benjamin et al<sup>2</sup>have conclusively demonstrated that delayed rupture of the spleen is an extremely rare clinical circumstance. In the vast majority of instances, splenic rupture is not delayed, but rather the recognition of splenic injury is delayed. The data of those authors<sup>1,2</sup>come from institutions in which diagnostic peritoneal lavage is routinely used in initial evaluation of suspected blunt abdominal trauma. Olsen reviewed 154 cases of splenic injury and found that all but two patients had capsular lacerations with hemoperitoneum detected on initial peritoneal
A case of right sided weakness
Authors: A. A. Mazumder, G. A. Pope
Journal: BMJ (2008)

A 77 year old right handed man presented with a history of resolving right sided weakness. His right arm and leg were affected, and his arm felt “heavier” than his leg. His wife noticed that his face drooped on the right side and that he used the “wrong words” when speaking. Within an hour of admission his weakness completely resolved, and a transient ischaemic attack was diagnosed. Forty eight hours after presentation, the patient re-presented to the accident and emergency department. He was reviewed by a trainee doctor (foundation year 2). He had a dense right sided hemiparesis, his right arm was worse than his right leg, and he had “forehead sparing” facial weakness. He was dysphasic, with his gaze preference to the left. His pulse was regular at 90 beats a minute and his blood pressure was 140/90 mm Hg. He had no clinical signs of meningism. His symptoms had been present for 30 minutes and had not improved.
Factors Involved in the Antinatriuretic Effects of Acute Constriction of the Thoracic and Abdominal Inferior Vena Cava
Authors: Robert W. Schrier, Michael H. Humphreys
Journal: Circulation Research (1971)

Studies were performed on anesthetized saline-loaded dogs to delineate the factors involved in the antinatriuretic effect of acute constriction of the thoracic (TIVC) and abdominal (AIVC) inferior vena cava. Acute TIVC constriction lowered cardiac output and arterial blood pressure and reduced urinary sodium excretion 48%; the same degree of reduction in renal perfusion pressure by suprarenal aortic constriction diminished sodium excretion only 27%. This finding suggested that factors other than a reduction in renal perfusion pressure are involved in the antinatriuretic effect of acute TIVC constriction. This conclusion was confirmed by studies in which a significant antinatriuretic effect (23%) was observed during acute TIVC constriction while renal perfusion pressure and renal venous pressure were held constant. A similar degree of constriction of the AIVC, as judged by the increase in vena cava pressure, did not cause a decrease in arterial pressure or cardiac output, and the modest antinatriuretic effect of this maneuver was not observed when renal venous pressure was held constant. The antinatriuretic effect of TIVC constriction which occurred in the absence of changes in renal perfusion pressure and renal venous pressure did not correlate with alterations in renal vascular resistance, glomerular filtration rate, and calculated initial postglomerular protein concentration and was not abolished by renal denervation or adrenalectomy. The afferent stimulus for the antinatriuretic effect may be related to the alterations in systemic hemodynamics which occur during acute TIVC, but not AIVC, constriction.
Elevated Pre-Operative Serum Peptides for Collagen I and III Synthesis Result in Post-Surgical Atrial Fibrillation
Authors: Michael F. Swartz, Gregory W. Fink, Muhammad F. Sarwar, George L. Hicks, Yao Yu, Rui Hu, Charles J. Lutz, Steven M. Taffet, José Jalife
Journal: Journal of the American College of Cardiology (2012)
Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice
Authors: Christophe M. Filippi, Elizabeth A. Estes, Janine E. Oldham, Matthias G. von Herrath
Journal: Journal of Clinical Investigation (2009)

Type 1 diabetes (T1D) is an autoimmune disease that is caused by the destruction of insulin-producing beta cells. Viral infections induce immune responses that can damage beta cells and promote T1D or on the other hand prevent the development of the disease. However, the opposing roles of viral infections in T1D are not understood mechanistically. We report here that viruses that do not inflict damage on beta cells provided protection from T1D by triggering immunoregulatory mechanisms. Infection of prediabetic NOD mice with Coxsackie virus B3 or lymphocytic choriomeningitis virus (LCMV) delayed diabetes onset and reduced disease incidence. Delayed T1D onset was due to transient upregulation of programmed cell death-1 ligand 1 (PD-L1) on lymphoid cells, which prevented the expansion of diabetogenic CD8+ T cells expressing programmed cell death-1 (PD-1). Reduced T1D incidence was caused by increased numbers of invigorated CD4+CD25+ Tregs, which produced TGF-beta and maintained long-term tolerance. Full protection from T1D resulted from synergy between PD-L1 and CD4+CD25+ Tregs. Our results provide what we believe to be novel mechanistic insight into the role of viruses in T1D and should be valuable for prospective studies in humans.
Minimally Invasive Coronary Artery Bypass Grafting
Authors: Cornelius Borst, Paul F. Gründeman
Journal: Circulation (1999)

Coronary Bypass: A Dissenting Opinion," Bonchek and Ullyot 1 express concerns about ill-guided attempts to deviate from the conventional revascularization procedure that is "safe, effective, durable, reproducible, complete, versatile, and teachable."In the present editorial, an experimental perspective on the search for less invasive surgical strategies is provided that will convey an opposite opinion.First, a brief reappraisal is warranted of the safety of coronary artery bypass graft surgery (CABG) during cardiac arrest supported by cardiopulmonary bypass (CPB). Safety of Conventional CABGThe great majority of CABG patients benefit greatly from coronary revascularization, but the surgical procedure is not without adverse effects.The Society of Thoracic Surgeons (STS) National Cardiac Surgery Database (January 1998) lists complications of 170 895 CABG-only operations, including 13 736 reoperations, performed in the United States in 1996.Operative mortality was 2.9% (2.5% in men, 4.0% in women).Operative mortality increases with age, from 1.1% at age 20 to 50 years to 7.2% at 81 to 90 years.In only 65.4% of procedures were no complications reported.Most complications are listed in the Table .Another way to assess the clinical outcome of conventional CABG is to analyze hospital discharge data from health insurance records. 2 Of 101 812 patients Ն65 years old operated on in January through October 1993 in the United States, 4.3% died in hospital.Of particular concern are patients (3.6%) who were discharged to a non-acute-care facility. 3wing to complications, 10.2% were discharged late (Ͼ14 days) to home.Thus, 81.9% were discharged to home in Յ14 days.In the first 2 months after discharge to home, 0.7% died and 9.9% were readmitted for cardiovascular, respiratory, or cerebrovascular reasons.Although each of these numbers needs to be carefully interpreted in its context, the Table and the health insurance data, 2 taken together, would seem to fall short of the "excellent outcomes" attributed to conventional CABG by Bonchek and Ullyot.
A piece of my mind. The reward
Authors: S. Massad
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antiarrhythmic Actions of Intravenous Ibutilide Compared With Procainamide During Human Atrial Flutter and Fibrillation
Authors: Bruce S. Stambler, Mark A. Wood, Kenneth A. Ellenbogen
Journal: Circulation (1997)

Background The selective class III antiarrhythmic agent ibutilide prolongs action potential duration and terminates atrial flutter (AFL) and fibrillation (AF), but the mechanism of its antiarrhythmic efficacy in humans has not been fully characterized. This study compared the antiarrhythmic effects of ibutilide with the class IA agent procainamide in humans during AFL and AF. Antiarrhythmic drug actions and electrophysiological characteristics of AFL and AF that enhanced pharmacological termination were investigated. Methods and Results Right atrial monophasic action potentials were recorded during 148 episodes of AFL (n=89) or AF (n=59) in 136 patients treated with intravenous ibutilide (n=73) or placebo (n=22) as participants in randomized, double-blinded comparative studies or intravenous procainamide (n=53) in a concurrent open-label study. The conversion rates in AFL with ibutilide, procainamide, and placebo were 64% (29 of 45 patients), 0% (0 of 33), and 0% (0 of 11), respectively, whereas in AF the rates were 32% (9 of 28), 5% (1 of 20), and 0% (0 of 11), respectively. In AFL, ibutilide increased atrial monophasic action potential duration (MAPD) more (30% versus 18%, P &lt;.001) and prolonged atrial cycle length (CL) less (16% versus 26%, P &lt;.001) than procainamide. Ibutilide shortened and procainamide prolonged action potential diastolic interval during AFL (−12% versus 51%, P &lt;.001). Ibutilide increased MAPD/CL ratio, whereas procainamide tended to decrease this ratio (13% versus −6%, P &lt;.01). In AF, ibutilide and procainamide induced similar increases in atrial CL (48% versus 45%), but ibutilide induced a greater increase in MAPD (52% versus 37%, P &lt;.05). Independent electrophysiological predictors of pharmacological arrhythmia termination were increase in MAPD/CL ratio ( P =.005) in AFL and longer baseline mean MAPD ( P =.011) in AF. Termination of AFL with ibutilide was characterized by significant increases in beat-to-beat atrial CL, MAPD, and diastolic interval variability. Ibutilide was significantly more effective in converting AF when the mean atrial CL was ≥160 ms (64% versus 0%, P &lt;.001) or MAPD was ≥125 ms (57% versus 0%, P =.002) at baseline. Conclusions Enhanced conversion efficacy of ibutilide compared with procainamide in AFL is correlated with a relatively greater prolongation of atrial MAPD than atrial CL, and termination of AFL by ibutilide is characterized by oscillations in atrial CL and MAPD. Conversion of AF by ibutilide is enhanced by a longer baseline mean atrial CL or MAPD.
Clinical Diagnosis and Management by Laboratory Methods
Authors: Carl E. Speicher
Journal: JAMA (1991)

A new edition of Henry's book, formerly the<i>Todd-Sanford-Davidsohn</i>text of the same name, is always greeted with anticipation, and the 18th edition is no exception. This is indeed the premier work that bridges the gap between clinical and laboratory medicine, and individuals working in both areas rely on it as their standard reference. How will the editor manage to capture the ever-expanding field of laboratory medicine, and how will the authors capsulize the vast material in their areas of interest in a limited number of pages? Besides a general updating and revision of virtually all the material in the text, some topics have received special attention. The first of the book's seven parts gives a thorough review of the "nuts and bolts" of the clinical laboratory, including instrumentation, reference values, and specimen collection and handling. There is a very nice discussion of interpretation of laboratory results and rule-based decision
Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering
Authors: Meng Deng, Lakshmi S. Nair, Syam P. Nukavarapu, Tao Jiang, William A. Kanner, Xudong Li, Sangamesh G. Kumbar, Arlin L. Weikel, Nicholas R. Krogman, Harry R. Allcock, Cato T. Laurencin
Journal: Biomaterials (2010)
Protective Ventilation for Patients Without Acute Respiratory Distress Syndrome—Reply
Authors: Ary Serpa Neto, Marcus J. Schultz
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal