tbuckley/cabot-search huggingface dataset:
Camp Thomas and the Second Division Hospital—The First Army Corps.
Authors: Fred R. Charlton
Journal: JAMA (1898)

Indianapolis,Ind., Sept. 24, 1898. <h3>To the Editor:</h3> —In view of the great concern now being manifested with regard to our military hospital service, I feel that a short statement as to the real condition will not be amiss. Leaving Indianapolis as Surgeon of the One Hundred and Fifty-eighth, with Dr. H.I. Jones, First and Dr. Paul Barcus, Second Assistant-Surgeon, we reached Chickamauga, May 18, 1898. The country was slightly rolling, with an almost regular alternation of wooded and open land. Everywhere were evidences of a lime formation, with many vertical out croppings of the strata. In the necessary trenchings the soil was found to be a clay so impervious to water that collections in sinks, etc., would evaporate rather than seep away into the subsoil. Owing to the rocky formation at the depth of about seven feet, sinks were at that time a practical impossibility. On May 25 I
In Vitro Migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation
Authors: Kazuo Ikeda, Tomoyuki Wakahara, Yan Qing Wang, Hirokazu Kadoya, Norifumi Kawada, Kenji Kaneda
Journal: Hepatology (1999)

In liver injury, hepatic stellate cells are considered to depart from the sinusoidal wall and accumulate in the necrotic lesion through migration and proliferation. In this study, we investigated the migratory capacity of quiescent stellate cells in vitro and analyzed the relationship with proliferative response. Freshly isolated stellate cells that were seeded in the upper chamber of Cell Culture Insert (Becton Dickenson, Franklin Lakes, NJ) started to migrate to the lower chamber at 1 day and increased in migration index to 19% at 2 days. Cells in the lower chamber were stretched in shape with many lipid droplets and showed quiescent properties, i.e. , negative expression of α–smooth muscle actin (α–SMA) or platelet–derived growth factor receptor–β (PDGFR–β). Migratory capacity in quiescent cells was also shown in the Matrigel–coated insert. Matrix metalloproteinase–2 (MMP–2) messenger RNA expression was low just after isolation, but was enhanced as migration became prominent. Migrating cells further showed higher proliferative activity than resting ones. The presence of PDGF/BB and Kupffer cells accelerated stellate cell migration by the chemotactic mechanism and concurrently augmented proliferation, whereas that of dexamethasone and interferon–γ (IFN–γ) attenuated migration as a result of general suppression effects. Compared with quiescent ones, α–SMA and PDGFR–β-positive activated stellate cells obtained by 14–day culture exhibited more rapid and prominent migration, being regulated by mediators in a similar manner as described previously. These data indicate that quiescent stellate cells undergo migration, which is linked to proliferation and enhanced by PDGF/BB and Kupffer cells, suggesting the involvement of this function in the initial phase of development of postnecrotic fibrosis.
Excuses for Poor Handwriting by Physicians—How I Save My Time and Waste Yours
Authors: Carolyn Ferree
Journal: JAMA (1986)

To the Editor.—  I wish to respond to the Letter to the Editor that appeared in the July 5 issue of JAMA  1 accusing physicians of every excuse ranging from illiteracy to being God in order to explain their poor handwriting.  I have no quarrel with the basic premise that illegible writing is dangerous, time consuming, and frustrating. However, I believe there is a more plausible explanation for this problem than that sarcastically presented in the letter. Having noted a deterioration in my own handwriting, I would like to offer the most likely and apparently the most common cause of this deterioration—lack of time.  The legibility of my handwriting began to decrease as I started medical school and attempted to take notes at the speed with which information was being dispensed. This note-taking process continued into the clinical training years, when there was never enough time, so my pace became
Coexistent Lymphosarcoma and Chronic Granulocytic Leukemia.
Authors: B. David Wilson, Ellis J. VanSlyck
Journal: Annals of Internal Medicine (1965)

s1 November 1965Coexistent Lymphosarcoma and Chronic Granulocytic Leukemia.B. David Wilson, M.D., Ellis J. VanSlyck, M.D., F.A.C.P.B. David Wilson, M.D.Search for more papers by this author, Ellis J. VanSlyck, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-911_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe coexistence of lymphosarcoma and leukemias of lymphocytic origin is well established, but that of lymphosarcoma and leukemia of granulocytic origin is very rare. We are reporting the case of a 54-year-old white male who was found to have lymphosarcoma of the cervical and mediastinal lymph nodes proven by biopsy and treated by irradiation. Two years later, he was found to have chronic granulocytic leukemia. This diagnosis was substantiated by typical peripheral blood and bone marrow findings and characteristic leukocyte alkaline phosphatase stain. The pH1was not found in marrow or peripheral blood. Rebiopsy of a peripheral lymph node reaffirmed... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 911-912KeywordsBiopsyBloodBone marrowLymph nodesLymphocytic leukemiaPhosphatases Issue Published: 1 November 1965 PDF downloadLoading ...
Anesthesia and Uncommon Diseases: Pathophysiologic and Clinical Correlations
Authors: James E. Cottrell
Journal: JAMA (1982)

In the second edition of this multiauthored book, previously existing chapters have been expanded and three new chapters incorporated. In addition, more contributors have been added to the list of distinguished medical specialists. This text should be used primarily for reference, since discussions of basic physiology and pathophysiology are difficult owing to their complex nature. Beginners in anesthesia curricula will have difficulty reading this book. The chapters are organized with great care and are properly sequenced. However, the quality of the chapters is inconsistent. Chapter 1 presents discussions of numerous genetically transmitted diseases, and is particularly important to those interested in medical minutiae. Chapter 2 contrasts with chapter 1 because of its lack of in-depth discussions of obstetric physiology and pathophysiology. Inconsistencies are noted, eg, "antacids may produce more pulmonary abnormalities than gastric aspirate," but another section concludes that "antacids are recommended." Vague generalizations regarding anesthesia for the geriatric patient
The New NEJM.org
Authors: Edward W. Campion, Lisa Scott, Cynthia Bowab, Sara Fleming, Theodore J. Blizzard, Christine Lamb, Thomas J. Easley, Jeffrey M. Drazen
Journal: New England Journal of Medicine (2010)

Each week, half a million readers access the Journal electronically, and our content is now seen online by about four times as many people as those who see the print edition. This mode of information delivery has expanded tremendously since the Journal first went online in 1996.(1) Not so long ago, electronic publishing was viewed as secondary to print publication, basically as a convenient way to deliver the print version of an article. Today, the electronic presentation of scientific articles has become the version of record, with print becoming only one part of the complete publication, which may include video, . . .
Book: Auscultation Skills: Breath and Heart Sounds
Authors: T. Gibbs
Journal: BMJ (2000)

Springhouse Publishing Butterworth-Heinemann, £30, pp 288 ISBN 0 87434 962 1 Rating: ![Graphic][1]</img> ![Graphic][2]</img> Few physicians would disagree with the opening comments from the foreword of this book: “In today's world of high technique medicine, auscultation is quickly becoming a lost art … many medical professionals now rely on tests for diagnosis rather than auscultation and physical diagnosis.” This book and its accompanying audio cassettes, which provide at least 40 various breath sounds and over … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
819-1 Endothelial dysfunction in children with human immunodeficiency virus: Impact of disease and protease inhibitor therapy
Authors: Marietta Charakida, Ann E Donald, Margaret Clapson, Clare Storry, Natalie Lloyd, Stavros P Loukogeorgakis, Julian Halcox, Nigel Klein, John E Deanfield
Journal: Journal of the American College of Cardiology (2004)
MOUSE-PROTECTIVE TITERS OF SERA OF VOLUNTEERS FOLLOWING INJECTION OF PNEUMOCOCCI OR THEIR TYPE-SPECIFIC POLYSACCHARIDES
Authors: Annabel W. Walter, Edna L. Schenkein, Wheelan D. Sutliff
Journal: The Journal of Experimental Medicine (1946)

1. Sera of human subjects immunized with pneumococci or their type-specific polysaccharides showed type-specific antibody by mouse protection tests as well as on determinations of the specifically precipitable nitrogen. 2. The ratio, mouse-protective units to antibody nitrogen, was less in human sera of low potency than in more potent human or animal sera.
Countries should consider legalising cannabis in light of futility of bans
Authors: Z. Kmietowicz
Journal: BMJ (2010)

The United States and other countries need urgently to consider ways of legalising the sale of cannabis, as attempts to stop its supply have resulted in all-out failure and led to major harms, says a group of leading scientists.

A report from the International Centre for Science in Drug Policy, a global network of scientists and academic doctors committed to reducing the harmful effects of illicit drugs, says that despite “aggressive criminal justice measures” in the US cannabis is widespread and readily available.

Federal funding for combating drugs in the US …
Missed Pharyngeal Foreign Body
Authors: George W. Siek
Journal: JAMA (1978)

To the Editor.—  The search for teeth or other dental appliances dislodged during intubation usually involves an oral examination and checking of the area surrounding the patient's head. A chest roentgenogram is then taken if the foreign body is not found. The foreign body is then assumed to be lost in the drapes, and all is well if the chest x-ray film is nonrevealing. This report illustrates the need also to examine the patient's neck by x-ray to establish that such a foreign body cannot become a hazard to the patient and to the anesthesiologist medicolegally.  Report of a Case. —  A 23-year-old woman was scheduled for extensive dental restoration of carious teeth. With the exception of severe caries, a history of heavy smoking with a chronic productive cough, and scattered dry rales throughout the lung fields, she was thought to represent a good anesthetic risk as evidenced by an
Superficial Thrombophlebitis of the Chest Wall
Authors: Waine C. Johnson
Journal: JAMA (1962)

Superficial thrombophlebitis of the chest wall usually presents as a subcutaneous cord 3 to 5 mm. in diameter aligned between the anterior axillary line or breast and the lower costal margin or umbilicus. In the past it has been confused with lymphatic spread of carcinoma, especially when involving the breast. This clinical and pathologic study of 7 patients supports the concept that the condition may be related to mechanical injury from effort or trauma. The data confirm reports of previous investigations that the lesion is benign and does not connote systemic disease or cancer.
Progressive Visual Loss Due to Obstruction of an Optic Nerve Sheath Fenestration Demonstrated on SPECT/CT Radionuclide Cisternography
Authors: Robert R. Russo, Leo Ha, Louise Emmett, Michael Magee, Robert Mansberg
Journal: Clinical Nuclear Medicine (2010)

A 35-year-old woman with a 7-year history of idiopathic intracranial hypertension (ICH) was referred for radionuclide cisternography. The symptoms of her ICH included severe migraines and bilateral visual loss. During the course of her illness the ICH was managed with insertion of cerebrospinal fluid (CSF) shunts. The duration of effect was limited due to the development of obstruction to drainage within these shunts. The progression of visual loss in the eyes prompted the creation of bilateral optic nerve sheath fenestration. This was performed 3 months before presentation. Despite this intervention the vision in the left eye continued to deteriorate. Radionuclide cisternography confirmed blockage of the left optic nerve sheath fenestration which responded to surgical decompression.
Highlights and a Hidden Hazard — The FDA's New Labeling Regulations
Authors: Jerry Avorn, William Shrank
Journal: New England Journal of Medicine (2006)

The Food and Drug Administration (FDA) is trying to make the official descriptions of prescription drugs — which are notoriously user-hostile — more helpful. The agency has acknowledged the linguistic toxicity of these documents, known as package inserts or labeling. These are the lengthy listings of drug indications, effects, and associated risks that are routinely included with medications when they are shipped to pharmacies — and just as routinely discarded by pharmacists before any drug is dispensed to patients. Physicians are more likely to see the labeling in tiny print in the voluminous Physicians' Desk Reference (PDR), one of the . . .
Clinical Trials Seek Proof of Efficacy
Authors: Marsha F. Goldsmith
Journal: JAMA (1997)

WHEN BROTHER Cadfael prescribed herbs and simples to heal his patients in Ellis Peters' popular medieval mystery series, it's safe to say he didn't worry about obtaining consent and setting up a control group of fasting monks or fainting maidens. If the remedies worked then they worked, and praise the Lord. The gratitude of patients (and rarely a fat purse) was Cadfael's reward. The conduct of 20th-century research on pharmaceuticals and therapies for still extant ancient ailments, as well as newer disorders, would surprise the good friar. The potential profitability of finding the most efficacious treatment for a disease would astound and perhaps trouble him. But his deep understanding of human nature would no doubt carry the day. It might even shed some light on how to approach maladies experts can't agree on how to fight and point the way to making clinical trials—the subject of this Contempo issue's MEDICAL
Warning of Massive Pulmonary Embolism
Authors: D. S. Short
Journal: BMJ (1967)

biliary reflux into the stomach which he has shown in these patients.It is suggested the epsilon amino-caproic acid therapy would be worthy of trial in patients with multiple bleeding gastric erosions.Suitable patients would be selected after gastroscopy or after surgery that is followed by recurrent bleeding.The drug could be administered parenterally, or into the stomach, or both.-I am, etc.,
Signal Transducer and Activator of Transcription 3 (STAT3) Regulates Collagen-Induced Platelet Aggregation Independently of Its Transcription Factor Activity
Authors: Zhou Zhou, Francisca C. Gushiken, Doug Bolgiano, Breia J. Salsbery, Niloufar Aghakasiri, Naijie Jing, Xiaoping Wu, K. Vinod Vijayan, Rolando E. Rumbaut, Roberto Adachi, Jose A. Lopez, Jing-fei Dong
Journal: Circulation (2012)

Platelet hyperactivity induced by inflammation is a known risk factor for atherosclerosis and thrombosis, but its underlying mechanisms remain poorly understood.The signal transducer and activator of transcription 3 (STAT3) was activated in collagen-stimulated platelets. Activated STAT3 served as a protein scaffold to facilitate the catalytic interaction between the kinase Syk (spleen tyrosine kinase) and the substrate PLCγ2 to enhance collagen-induced calcium mobilization and platelet activation. The same interaction of STAT3 with Syk and PLCγ2 was detected in HEK293 cells transfected with cDNAs for Syk and PLCγ2 and stimulated with interleukin-6. Pharmacological inhibition of STAT3 blocked ≈50% of collagen- and a collagen-related peptide-induced but not thrombin receptor-activating peptide- or ADP-induced aggregation and ≈80% of thrombus formation of human platelets on a collagen matrix. This in vitro phenotype was reproduced in mice infused with STAT3 inhibitors and mice with platelet-specific STAT3 deficiency. By forming a complex with its soluble receptor, the proinflammatory cytokine interleukin-6 enhanced the collagen-induced STAT3 activation in human platelets.These data demonstrate a nontranscriptional activity of STAT3 that facilitates a crosstalk between proinflammatory cytokine and hemostasis/thrombosis signals in platelets. This crosstalk may be responsible for the platelet hyperactivity found in conditions of inflammation.
New Basic Care Goals Seek to Rein In Global Rise in Cardiovascular Disease
Authors: Mike Mitka
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aryl sulfatase a in acute nonlymphocytic leukemia
Authors: M. V. Pillai, G. W. James, M. E. King, F. W. Fox, S. C. Choi
Journal: American Journal of Hematology (1982)

Abstract To ascertain whether estimation of urinary aryl sulfatase A (ASA) is a reliable noninvasive technique for monitoring disease activity in adult acute nonlymphocytic leukemia, we studied the excretion pattern of this enzyme during active disease, partial remission, and complete remission in ten patients and compared the results with those of ten healthy volunteers. There was no significant difference in enzyme excretion between complete remission cases and the control group. Patients with partial remission and active disease had significantly different urinary enzyme levels from each other and from the control and complete remission groups. Estimation of urinary ASA is a useful noninvasive method of monitoring disease activity in adult acute nonlymphocytic leukemia.
Commitment of Immature CD4+8+ Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains
Authors: Harumi Suzuki, Yoichi Shinkai, Lawrence G. Granger, Frederick W. Alt, Paul E. Love, Alfred Singer
Journal: The Journal of Experimental Medicine (1997)

As a consequence of positive selection in the thymus, immature CD4(+)8(+) double-positive, [DP] thymocytes selectively terminate synthesis of one coreceptor molecule and, as a result, differentiate into either CD4(+) or CD8(+) T cells. The decision by individual DP thymocytes to terminate synthesis of one or the other coreceptor molecule is referred to as lineage commitment. Previously, we reported that the intrathymic signals that induced commitment to the CD4 versus CD8 T cell lineages were markedly asymmetric. Notably, CD8 commitment appeared to require lineage-specific signals, whereas CD4 commitment appeared to occur in the absence of lineage-specific signals by default. Consequently, it was unclear whether CD4 commitment, as revealed by selective termination of CD8 coreceptor synthesis, occurred in all DP thymocytes, or whether CD4 commitment occurred only in T cell receptor (TCR)-CD3-signaled DP thymocytes. Here, we report that selective termination of CD8 coreceptor synthesis does not occur in DP thymocytes spontaneously. Rather, CD4 commitment in DP thymocytes requires signals transduced by either CD3 or zeta chains, which can signal CD4 commitment even in the absence of clonotypic TCR chains.
Effect of Hypertonic Glucose on the Muscular Cramps of Hemodialysis
Authors: J. MILUTINOVICH
Journal: Annals of Internal Medicine (1979)

The effect of hypertonic (50%) glucose injected for relief of hemodialysis-induced muscular cramps was studied in 15 chronically uremic, nondiabetic patients who experienced a total of 44 cramp episodes. In a double-blind trial either 50 mL (or less) of hypertonic glucose or physiologic (0.9%) saline solution was injected, and the therapeutic response was evaluated. Of a total of 44 episodes of cramps, 26 were treated with hypertonic glucose and 18 with normal saline. Treatment with hypertonic glucose relieved 17 of 26 episodes, in contrast to only five of 18 episodes relieved with 50 mL of normal saline (P less than 0.016). No complications related to hypertonic glucose administration were observed. Hypertonic glucose seems to be safe and effective for the relief of dialysis-induced cramps. It also avoids undesirable loading with sodium and mannitol, which have been suggested for treatment of dialysis-induced cramps.
Activation of neutral metalloprotease in human osteoarthritic knee cartilage: evidence for degradation in the core protein of sulphated proteoglycan.
Authors: J Martel-Pelletier, J P Pelletier, C J Malemud
Journal: Annals of the Rheumatic Diseases (1988)

The neutral, metal dependent, proteoglycan degrading enzymes (NMPEs) in human osteoarthritic knee cartilage homogenates were activated by p-aminophenylmercuric acetate (APMA). The resultant effect on the structure of newly synthesised and already existing sulphated proteoglycan was measured. Newly synthesised and already existing proteoglycan aggregated to hyaluronic acid was reduced (p less than 0.01, p less than 0.05 respectively) when measured by chromatography on Sepharose CL-2B eluted with associative buffer. The APMA activated enzyme affected both the newly synthesised and already existing proteoglycan aggregate similarly (r = 0.79, p less than 0.001). Treatment of cartilage homogenates with APMA and 1,10-phenanthroline (10 mM) showed that the amount of aggregated proteoglycan was at the control level. The hydrodynamic size of the proteoglycan monomer (A1D1) was also reduced by treatment of cartilage homogenates with APMA. Reaggregation experiments with fraction A1D1 and exogenous hyaluronic acid and link protein showed a similar defect in forming proteoglycan aggregates. These data showed that activation of the NMPEs altered the structure of proteoglycan in two ways. The most consistent change was a reduction in the ability of proteoglycan to form aggregates with hyaluronic acid. This was likely to have occurred via a cleavage of the core protein in or around the hyaluronic acid binding globular domain. A second alteration probably includes a limited proteolytic cleavage in the remainder of the core protein.