tbuckley/cabot-search huggingface dataset:
Fasting and Chemotherapy
Authors: Tracy Hampton
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
End-Stage Renal Disease Core Indicators Project
Authors: Bruce C. Vladeck
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contribution from geriatric medicine within acute medical wards.
Authors: L E Burley, C T Currie, R G Smith, J Williamson
Journal: BMJ (1979)

In 1977 a scheme of attachment to acute medical wards of consultants in geriatric medicine and associated junior medical staff was instituted in a large Edinburgh teaching hospital. The effect on admissions of patients aged 65 and over was examined for comparable periods before and during this arrangement. Mean and median stays were reduced for both sexes but more noticeably for women. The mean stay for all women aged over 65 was reduced from 25 to 16 days and for women aged over 85 from 50 to 19 days. The proportion staying under two weeks was significantly increased in both sexes, and the proportion discharged home also increased, correspondingly fewer patients being transferred to convalescent wards. These changes were not accompanied by increased transfers to the geriatric department, and probably the skills and extra resources available to the geriatric service were the factors mainly responsible for the changes in performance.
A Condition Resembling Severe Preeclampsia Occurring under Anaesthesia and Associated with Scoline Apnoea
Authors: E. C. Wood, T. A. Boliston
Journal: BMJ (1961)

Pain.-An attempt at assessing the prognostic importance of initial pain had to be abandoned owing to difficulties in estimating degrees of pain, often in retrospect.Decompression.-Decompression of the facial nerve in the temporal bone was carried out at my request by Mr. R. L. Flett in five patients in whom no movement had been observed after 12 weeks.No dramatic results were observed, and the final result in all was assessed as grade 3.In six comparable patients who were not operated on the results were very similar, five being assessed as grade 3 and one as grade 2. Obviously, no conclusions on the efficacy of this form of treatment can be drawn on these few patients operated on so late in the course of the palsy.
Abstract 4769: Relevance of the TRIF pathway for in vivo gp96-mediated CD8+ T cell cross presentation
Authors: Ernesto Luna, Masayuki Fukata, Natasa Strbo, Maria T. Abreu, Eckhard R. Podack
Journal: Cancer Research (2010)

Abstract Heat shock protein gp96 is an intracellular chaperone for proteins and peptides generated during protein synthesis and degradation. Different candidate receptors including CD91, TLR2 and TLR4 have been shown as important binders in the gp96 mediated cross-priming process. Both TLR2 and TLR4 use the common MyD88 signaling pathway suggesting it is an important mediator of gp96-mediated cross-priming. Our group has produced a secreted form of hsp-gp96, a fusion protein gp96-Ig. Ggp96-Ig-transfected tumor cells secrete gp96-Ig in vivo and cross prime CD8 CTL that are specific for genuine tumors antigens (Ag) and for the surrogate Ag OVA. In this work, we studied the role of both MyD88 and TRIF signaling pathways in gp96-mediated cross presentation. Briefly, one million of ovalbumin specific T cell receptor (TCR) transgenic CD8+ cells (OT-I)-gfp, were transferred intravenously into MyD88 deficient (MyD88−/−) mice, TRIF deficient (TRIF Lps2/Lps2) mice and C57/BL6 wild type (B6-WT) mice as control. Two days later the mice were immunized intraperitoneally with two million of 3T3-gp96-mIgG1-OVA cells or 3T3-OVA cells respectively. Five days later, we obtained peritoneal cells (PECs) and splenocytes in order to analyze OT-I-gfp expansion, IFNγ production, CD107a degranulation and cytokine (IL-6, TNFα, IL-10) production by ELISA. Gp96 induced CD8 CTL (OT-I) expansion is significantly increased in MyD88−/− mice compared to WT mice and significantly decreased in TRIF deficient mice. However, the frequency of IFNγ expression in CTL is diminished in MyD88−/− while is normal in TRIF deficient mice. IL-6 and TNFα production by antigen presenting cells isolated from the peritoneal cavity, was reduced in MyD88−/− mice compared with WT and TRIF deficient mice. The data indicate that both, MyD88 and TRIF mediated signals are required for full CD8 CTL expansion and cytotoxic differentiation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4769.
The dorsal system and the ecological self
Authors: Ulric Neisser
Journal: Behavioral and Brain Sciences (2002)

Perception, as Gibson described it – picking up information that specifies the real local situation – includes not only perceiving affordances and controlling small movements, but also seeing the large-scale environmental layout and the position/movement of the “ecological self.” If the dorsal cortical system is also responsible for that very significant achievement, its activity must be at least partly conscious.
RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
Authors: Matthias Ilmer, Alejandro Recio Boiles, Ivonne Regel, Kenji Yokoi, Christoph W. Michalski, Ignacio I. Wistuba, Jaime Rodriguez, Eckhard Alt, Jody Vykoukal
Journal: Cancer Research (2015)

Abstract Cancer stem cells (CSC) present a formidable clinical challenge by escaping therapeutic intervention and seeding tumors through processes that remain incompletely understood. Here, we describe small subpopulations of pancreatic cancer cells with high intrinsic Wnt activity (Wnthigh) that possess properties indicative of CSCs, including drug resistance and tumor-initiating capacity, whereas cell populations with negligible Wnt activity (Wntlow) preferentially express markers of differentiation. Spontaneous response to extrinsic Wnt signals induces signaling networks comprising ERK1/2 and epithelial–mesenchymal transition that subsequently confer cancer stemness traits to susceptible cells. Wnt enhancer R-Spondin 2 (RSPO2) seems to play a prominent upstream role in regulating this interplay. In this context, Wnthigh cells were more likely to give rise to Wnthigh progeny, tended to be more metastatic, and revealed higher levels of RSPO2 expression. Our studies reveal adaptive aspects of pancreatic cancer stemness arising from driver populations of CSCs that misappropriate functional and responsive elements of archetypical self-renewal pathways. Blocking such stemness-promoting pathways in conjunction with established chemotherapy could provide means to disrupt dynamic CSC process and present novel therapeutic targets and strategies. Cancer Res; 75(9); 1883–96. ©2015 AACR.
The Physician and Postmyocardial Infarction Invalidism
Authors: Robert F. Klein
Journal: JAMA (1965)

A study of 20 male survivors of myocardial infarction confirmed a clinical impression that moderate to severe invalidism often occurs in the absence of definable physical residuals of the infarction. The cultural meaning of the heart attack was found to be prominently concerned with fear of sudden death and fear of physical activity. A failure in the revision of concepts derived from the acute phase of the infarction was observed in the invalid patients and their spouses. Physician uncertainty regarding the source of somatic symptoms in invalidism was observed to exert both a delay in the recognition of the syndrome and a perpetuating effect.
Lymphovenous shunts in man
Authors: J. M. Edwards, J. B. Kinmonth
Journal: BMJ (1969)

Lymphovenous shunts have been detected in patients by lymphography with Ultrafluid Lipiodol. No shunts were found in patients with normal lymphatic systems. They were found in patients with lymphoedema, with lymph nodes involved by malignant disease, and in patients who had had surgical interruption of lymphatic pathways, either vessels or nodes. The total incidence of lymphovenous shunts in 700 lymphographic studies was 2·3%. The incidence in the various pathological groups was highest in those with obvious lymph node involvement. In certain situations, particularly primary lymphoedema, the role of a lymphovenous shunt appears favourable to prognosis. In other situations a deleterious effect may be produced.
A Better Method for Preventing Adverse Clinical Events Caused by Implantable Cardioverter-Defibrillator Lead Fractures?
Authors: Robert G. Hauser
Journal: Circulation (2008)

the Medtronic Sprint Fidelis implantable cardioverter-defibrillator (ICD) lead was voluntarily withdrawn from the market by the manufacturer because of a higher-than-expected fracture rate. 1 Most Sprint Fidelis fractures involve the pace-sense component of the lead, which may cause oversensing of electrical artifacts, undersensing of ventricular depolarizations, and/or loss of ventricular capture.Approximately 10% to 20% of Sprint Fidelis fractures involve the high-voltage conductor, which may compromise defibrillation.][4] Inappropriate shocks may be proarrhythmic and lethal, 5,6 and patients who experience them may suffer psychological sequelae.ICD lead failures are more likely to result in oversensing than pacemakers because the ICD pulse generators use high-sensitivity amplifiers to effectively detect ventricular fibrillation (VF).In this issue of Circulation, Swerdlow et al 7 describe a new algorithm that may avoid or reduce inappropriate shocks and other serious adverse events in patients with failed Sprint Fidelis and possibly other highvoltage leads.If this algorithm proves to be safe and effective, it will be an important advance in ICD therapy.
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
Authors: Jian Q Feng, Leanne M Ward, Shiguang Liu, Yongbo Lu, Yixia Xie, Baozhi Yuan, Xijie Yu, Frank Rauch, Siobhan I Davis, Shubin Zhang, Hector Rios, Marc K Drezner, L Darryl Quarles, Lynda F Bonewald, Kenneth E White
Journal: Nature Genetics (2006)
The Dreams of a Medical Resident
Authors: Abraham Verghese
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Capillary Thrombosis in Septicemia Due to Gram-Positive Bacteria
Authors: Frederic G. Dalldorf
Journal: JAMA (1968)

Septicemia was associated with widespread pulmonary capillary thrombosis in two fatal cases. The first was caused by<i>Clostridium perfringens</i>and the second by group-A streptococci. Electrocardiographic, morphologic, and experimental evidence suggests that the shock-like terminal phase of the infection may have been caused by pulmonary capillary thrombosis and acute cor pulmonale.
Hyperpnea limits the volume recruited by positive end-expiratory pressure.
Authors: A Chandra, J W Coggeshall, S A Ravenscraft, J J Marini
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

The effectiveness of positive end-expiratory pressure (PEEP) relates directly to alveolar recruitment. We tested the hypothesis that active use of expiratory muscles during labored breathing impairs the ability of PEEP to increase end-expiratory lung volume. Eight healthy volunteers naive to the purposes of our study were exposed to targeted end-expiratory pressures of 0, 5, and 10 cm H2O during mechanical ventilation applied by mouthpiece and noseclips at three levels of ventilation: resting and two levels (moderate and high) of CO2 stimulation (10.9 +/- 0.4, 19.9 +/- 0.5 and 27.5 +/- 0.5 L/min, respectively). Inductive plethysmography demonstrated that end-expiratory lung volume rose by an average of 98 +/- 5 ml/cm H2O PEEP during quiet breathing but by much less during the two levels (moderate and high) of CO2 stimulation: 78 +/- 6 ml/cm H2O and 47 +/- 5 ml/cm H2O (p < 0.05). Hyperpnea also shifted the distribution of the recruited volume toward regions sampled by the rib cage band of the plethysmograph. Whatever advantage expiratory muscle activity may have for minimizing the workload of the inspiratory muscles, the cost may be reduced effectiveness of PEEP in increasing lung volume and improving oxygen exchange.
A case of Tubal Gestation: Primary Intraperitoneal Rupture: Operation: Recovery
Authors: B. Dyball
Journal: BMJ (1904)

CAsE IV.Mrs. D., aged 35, a most nervous and hlsterical patient, had been in labour some hours before I saw her, the membranes having ruptured early.The os was dilated to the size of a shilling and the vertex was pressing on the lower uterine segment.The patient complained of great pain and the uterine contractions were of little or no use as wregards further dilatation.I administered chloroform to a slight extent and waited for three 'hours.The condition did not improve, and as the patient was worn .outand in an exceedingly nervous state I pushed the chloroform, gradually dilated the os and, applying forceps, delivered her with -difficulty of a large stillborn child.The patient made a splendid 'recovery.
The<sup>198</sup>Au Liver Scan
Authors: Donald O. Castell, Raymond B. Johnson
Journal: New England Journal of Medicine (1966)

LIVER scanning with radioactive isotopes has become a frequently used procedure in the study of patients with various forms of liver disease. Most recent reports suggest that liver scanning is primarily helpful for detection of space-occupying lesions of the liver and is of questionable value in the study of patients with diffuse hepatic parenchymal disease.It is the purpose of this report to show that hepatic photoscanning with radioactive colloidal gold (198Au) may be a useful procedure for evaluating the degree of portal–systemic collateral circulation in patients with chronic liver disease.MethodsPatients StudiedTwenty patients with chronic liver . . .
MicroRNA expression profiling in classic Hodgkin lymphoma
Authors: Alfons Navarro, Anna Gaya, Antonio Martinez, Alvaro Urbano-Ispizua, Aina Pons, Olga Balagué, Bernat Gel, Pau Abrisqueta, Armando Lopez-Guillermo, Rosa Artells, Emili Montserrat, Mariano Monzo
Journal: Blood (2007)
Boy With Yellow-Orange, Rough Nodule on Right Thigh
Authors: Sara Flores, Jonathan Johnson, Phillip Young, Megha Tollefson
Journal: JAMA Pediatrics (2014)

An 8-year-old otherwise healthy boy presented with a yelloworange, roughnoduleonhismedial right thigh (Figure 1). It hadevolved from a flat discoloration since the age of 3 years, which continued to slowly enlarge and thicken. The patient denied spontaneous bleeding or ulceration, and he had full range of motionanduseofhis extremity.Neitherhe nor his family members reported a history of similar lesions on their body. He did not take any medications, had never been hospitalized, andhadneverhadanymajor surgical procedures.His upper and lower extremities were otherwise normal. On inspection, there was a 4.5 cm × 3.5cm,verrucousplaquewithunderlying fullnessontherightmedial thigh. Therewere alsopunctate vessels evident on thehyperkeratotic surface. Figure 1. Close-up of lesion at presentation. A verrucous, vascular plaque with underlying fullness on the right medial thigh. There were also punctate vessels evident on the hyperkeratotic surface.
Essential Features of a Surveillance System to Support the Prevention and Management of Heart Disease and Stroke
Authors: David C. Goff, Lawrence Brass, Lynne T. Braun, Janet B. Croft, Judd D. Flesch, Francis G.R. Fowkes, Yuling Hong, Virginia Howard, Sara Huston, Stephen F. Jencks, Russell Luepker, Teri Manolio, Christopher O’Donnell, Rose Marie Robertson, Wayne Rosamond, John Rumsfeld, Stephen Sidney, Zhi Jie Zheng
Journal: Circulation (2006)
Continuous intragastric feeding in infants.
Authors: R P Barclay, I Mitchell
Journal: BMJ (1972)

if assumptions are made that there are ab- normally high frequencies of the fluoride or silent genes present in these groups.Assum- ing that only the usual (Elu) and atypical (Ela) genes are present, the observed (0) and expected (E) distributions of phenotypes by D.N. number are indicated in my Table.In both patient groups there appears to be selection of marked degree, apparently in favour of heterozygotes or against homozy- gotes.The abnormally high frequency of the Ela gene suggests that the selection is largely against the atypical homozygotes.On this basis the real frequency of this gene in leprosy patients may be much higher than the data suggest.One can merely speculate on the nature of the selection involved but analysis of the data in respect of age of the patients and severity of their disease seems warranted.-I
Differences in Effects of Cigar and Cigarette Smoking on Free Fatty Acid Mobilization and Catecholamine Excretion
Authors: Alfred Kershbaum
Journal: JAMA (1966)

A study was made of the comparative effect of cigar and cigarette smoking on the mobilization of free fatty acids (FFA) and the excretion of catecholamines. There was a greater increase in FFA concentration in the serum with cigarette than with cigar smoking. Inhaling during smoking caused a greater FFA response than not inhaling, with both cigars and cigarettes. With tobacco containing glucose randomly labeled with radioactive carbon (<sup>14</sup>C), there was a greater absorption of<sup>14</sup>C with cigarette smoking. Urinary catecholamine excretion increased during smoking, significantly more with cigarettes than with cigars. The differences observed with the two forms of smoking probably result from the tendency to inhale with cigarette and not with cigar smoking and from the effect of this on nicotine absorption.
Heritage of Excellence: The Johns Hopkins Medical Institutions, 1914-1947
Authors: Marjorie C. Meehan
Journal: JAMA (1974)

Wherein lies the excellence of a medical institution? Is it in the quality of education provided? The stimulation given to well-chosen capable students? The care given to patients, providing their health and comfort? Is it in the number and quality of research reports published? Turner, who was dean of the medical faculty of Johns Hopkins for 11 years, apparently considers that excellence lies in the achievements and reputation of the senior faculty.  This book, as a history of the Johns Hopkins medical institutions from 1914 to 1947, is actually a history of the senior faculty and top administration during that time. Every professor is identified, furnished with a biography, an account of all his appointments and honors, a full list of the members of the search committee that appointed him, and sometimes even a description of the rejected candidates. Sometimes a brief personal description reflects Turner's attitude. For example, he
Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle
Authors: Paul Robach, Gaetano Cairo, Cecilia Gelfi, Francesca Bernuzzi, Henriette Pilegaard, Agnese Viganò, Paolo Santambrogio, Paolo Cerretelli, José A. L. Calbet, Stéphane Moutereau, Carsten Lundby
Journal: Blood (2007)
1051-128 Infant Norwood patients become sensitized to donor HLA antigens but not tolerized to incompatible donor ABO antigens following homograft implantation
Authors: Natalia E Lobach, Lisa Hornberger, Jeffrey F Smallhorn, Anne I Dipchand, Neal denHollander, Glen VanArsdell, Stacey M Pollock-BarZiv, Lori J West
Journal: Journal of the American College of Cardiology (2004)