An Unusual Skin Rash Associated with a Pancreatic Polypeptide-Producing Tumor of the Pancreas
Authors: ULUPl A. CHOKSI
Journal: Annals of Internal Medicine (1988)

Brief Reports1 January 1988An Unusual Skin Rash Associated with a Pancreatic Polypeptide-Producing Tumor of the PancreasULUPl A. CHOKSI, M.D., RENA V. SELLIN, M.D., ROBERT C. HICKEY, M.D., NAGUIB A. SAMAAN, M.D., Ph.D.ULUPl A. CHOKSI, M.D.Search for more papers by this author, RENA V. SELLIN, M.D.Search for more papers by this author, ROBERT C. HICKEY, M.D.Search for more papers by this author, NAGUIB A. SAMAAN, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-1-64 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPancreatic polypeptide is a newly identified secretory product from pancreatic islet cell tumors (1, 2). This peptide has been seen with increasing frequency in different islet cell tumors and is considered a marker for such tumors (3, 4). Recently, a few predominantly pancreatic polypeptide-producing tumors also have been reported (3, 5-7). Most islet cell tumors have a characteristic clinical presentation, but the pancreatic polypeptide-producing tumors identified so far have not been associated with a distinctive clinical presentation.We treated a patient with a pancreatic polypeptide-producing tumor associated with distinctive skin rash. The skin rash improved with successful treatment of the...References1. KIMMELPOLLOCKHAZELWOOD JHR. A new polypeptide hormone [Abstract]. Fed Proc. 1971;30:1318. Google Scholar2. LINCHANCE TR. Candidate hormones of the gut. VI. Bovine pancreatic polypeptide (BPP) and avian pancreatic polypeptide (APP). Gastroenterology. 1974;67:737-8. MedlineGoogle Scholar3. FRIESENKIMMELTOMITA SJT. Pancreatic polypeptide as a screening marker for pancreatic polypeptide apudomas in multiple endocrinopathies. Am J Surg. 1980;139:61-72. CrossrefMedlineGoogle Scholar4. ADRIANUTTENTHALWILLIAMSBLOOM TLSS. Secretion of pancreatic polypeptide in patients with pancreatic endocrine tumors. N Engl J Med. 1986;315:287-91. CrossrefMedlineGoogle Scholar5. LUNDQVISTKRAUSELARSSON GUL. A pancreatic polypeptide-producing tumor associated with the WDHA Syndrome. Scand J Gastroenterol. 1978;13:715-8. CrossrefMedlineGoogle Scholar6. HAYES M. Report of a pancreatic polypeptide-producing islet-cell tumor of the pancreas causing the watery diarrhea, hypokalemia, achlorhydria syndrome in a 55-year-old Zimbabwean African male. Cent Afr J Med. 1980;26:195-7. MedlineGoogle Scholar7. BORDITOGNIBAETENSRAVAZZOLAMALAISSE-LAGAEORCI CRDMFL. Human islet cell tumor storing pancreatic polypeptide: a light and electron microscopic study. J Clin Endocrinol Metab. 1978;46:215-9. CrossrefMedlineGoogle Scholar8. GREENBERGMCCLOYADRIANCHADWICKBARONBLOOM GRTVJS. Inhibition of pancreas and gallbladder by pancreatic polypeptide. Lancet. 1978;2:1280-2. CrossrefMedlineGoogle Scholar9. OOIKAMEYATSUMURAYA ATM. Pancreatic endocrine tumors associated with WDHA syndrome: an immunohistochemical and electron microscopic study. Virchows Arch [A]. 1985;405:311-23. CrossrefGoogle Scholar10. TOMITAFRIESENKIMMELDOULLPOLLOCK TSJVM. Pancreatic polypeptide-secreting islet-cell tumors: a study of three cases. Am J Pathol. 1983;113:134-42. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ULUPl A. CHOKSI, M.D.; RENA V. SELLIN, M.D.; ROBERT C. HICKEY, M.D.; NAGUIB A. SAMAAN, M.D., Ph.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVIPoma and PPomaSystemic Disease and the SkinEritemas figuradosSporadic Pancreatic Polypeptide Secreting Tumors (PPomas) of the PancreasSurgical treatment of non-functioning pancreatic islet cell tumorsMorphological and functional investigations of neuroendocrine tumors of the pancreasPancreatic Polypeptide Hypersecretion Associated with a Neuroendocrine Carcinoma of the GallbladderPancreatic Polypeptide Hypersecretion Associated with a Neuroendocrine Carcinoma of the GallbladderPankreatischer Polypeptid-sezernierender endokriner Pankreastumor assoziiert mit multiplen Ulcera ventriculi et duodeniIslet Cell Tumors of the PancreasTumours and Hyperplasias of the Endocrine PancreasPancreatic polypeptide (PP)-producing tumors (PPomas): A review of the literature and statistical analysis of 58 casesMetastatic Pancreatic Polypeptide Producing Tumour Presenting with Diabetes MellitusMultiple hormone elevations in Zollinger-Ellison syndromeNecrolytic migratory erythema: association with neuroendocrine tumour with predominant insulin secretionFunctional endocrine tumors of the pancreas: Clinical presentation, diagnosis, and treatmentRecent Advances in Medicine (1988).Migratory Erythema and Glucagonoma: Descriptive NomenclatureWALTER H. C. BURGDORF, M.D. 1 January 1988Volume 108, Issue 1Page: 64-65KeywordsPancreasPolypeptidesRashes ePublished: 1 December 2008 Issue Published: 1 January 1988 PDF downloadLoading ...