tbuckley/cabot-search huggingface dataset:
A STUDY OF LABOR IN CONTRACTED PELVES
Authors: ALICE F. MAXWELL
Journal: JAMA (1927)

The method of trial and error is a most effective agent for the advancement of all science, and orderly knowledge and obstetrics progress by experiment and accurate observations. Mature and safe judgment can come only as a crystallization of personal experience.  A thoughtful study of the problems of maternal and fetal mortality is of tremendous significance, and factors that may contribute to the death rate of mother or child are of vital importance. With this purpose in mind, I have made an analysis of the effect of pelvic contractions on the outcome of labor in 6,500 cases delivered in the obstetric department of the University of California Hospital.  CLASSIFICATION OF CONTRACTED PELVES  It is apparent that any grouping of types of pelves must be unsatisfactory, for the size of the pelvis is only one of the components relating to the mechanism of labor. The actual spacial relationship of the bony
Menopause and Depression
Authors: Quentin R. Regestein
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Although there may be no specific association between menopause and depressive symptoms in psychiatric patients, as reported by Myrna M. Weissman, PhD (242:742, 1979), there may be in others. A higher occurrence of anxiety and mood depression around the time of menopause has been noted in gynecologic patients.<sup>1</sup>Furthermore, suicide as well as mental illness in general show peak incidences during the menopausal years.<sup>2,3</sup>Depressive symptoms such as insomnia, irritability, and somatic preoccupations may in some cases be related to estrogen lack, because they are alleviated by estrogen replacement.<sup>4</sup>Certain changes in menopausal women of some brain enzymes or neurotransmitters subserving mood may be risk factors for depression,<sup>5</sup>and, therefore, clinical and research interest in the possible association between menopause and depression ought to be maintained.
Hypercalcaemia, Hypophosphataemia, and Inability to Excrete Hydrogen Ions
Authors: H. Arcila, J. C. de Los Rios, R. Van Dyck, E. Zorrilla
Journal: BMJ (1972)

Investigation of a patient with hypercalcaemia, hypophosphataemia, and nephrocalcinosis failed to lead to a clear diagnosis. Neither primary hyperparathyroidism nor primary incomplete renal tubular acidosis could explain all the biochemical features, and it seems that more than one fundamental abnormality may have been present.
Effects of Intravenous Nicorandil Before Reperfusion for Acute Myocardial Infarction in Patients With Stress Hyperglycemia
Authors: Hideki Ishii, Satoshi Ichimiya, Masaaki Kanashiro, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara
Journal: Diabetes Care (2006)

OBJECTIVE—Stress hyperglycemia increases the risk of mortality and poor outcomes in patients with acute myocardial infarction (AMI). We aimed to assess effects of intravenous nicorandil administered before reperfusion on AMI patients with stress hyperglycemia. RESEARCH DESIGN AND METHODS—This study consisted of 158 consecutive first AMI patients with stress hyperglycemia who underwent percutaneous coronary intervention (PCI) within 24 h from the onset. They were randomly assigned to receive 12 mg of nicorandil (n = 81) or a placebo (n = 77) intravenously just before reperfusion. Stress hyperglycemia was defined as a blood glucose level ≥10 mmol/l (180 mg/dl). We examined various aspects of epicardial flow and microvascular function as immediate data and major adverse cardiac events (MACEs) (coronary heart disease death or unplanned readmission due to congestive heart failure) as late-phase data. RESULTS—The incidence of slow flow after PCI was lower in the nicorandil group (13.6 vs. 27.3%, P &amp;lt; 0.04). ST segment resolution &amp;gt;50% was observed in 70.4 and 53.2% on nicorandil and placebo, respectively (P &amp;lt; 0.03). Patients treated with nicorandil had a lower peak creatine kinase level (3,137 ± 2,577 vs. 4,333 ± 3,608, P &amp;lt; 0.02). Upon Kaplan-Meier analysis, 5 years’ freedom from MACEs was 86.4% in the nicorandil group and 74.0% in the placebo (P &amp;lt; 0.05). CONCLUSIONS—Adjunctive therapy with administration of intravenous nicorandil before reperfusion on AMI patients with stress hyperglycemia significantly improves epicardial flow and prevents the occurrence of severe microvascular reperfusion injury, resulting in better outcomes in these patients.
CALCINOSIS CUTIS.
Authors: B. C. TATE, H. B. TRUMPER
Journal: British Journal of Dermatology (1933)

Journal Article CALCINOSIS CUTIS: (REPORT OF A CASE.) Get access B. C. TATE, M.A., M.B., M.R.C.P., B. C. TATE, M.A., M.B., M.R.C.P. From the Skin Department, The General Hospital, Birmingham Search for other works by this author on: Oxford Academic Google Scholar H. B. TRUMPER, B.A., B.Ch H. B. TRUMPER, B.A., B.Ch From the Skin Department, The General Hospital, Birmingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 10, 1 October 1933, Pages 413–418, https://doi.org/10.1111/j.1365-2133.1933.tb10113.x Published: 01 October 1933
Abstract LB-427: TAK1 (MAP3K7) inhibition promotes apoptosis in KRAS dependent colon cancers
Authors: Anurag Singh, Michael F. Sweeney, Min Yu, Alexa Burger, Patricia Greninger, Cyril Benes, Daniel A. Haber, Jeff Settleman
Journal: Cancer Research (2012)

Abstract Colon cancers frequently harbor KRAS mutations, yet only a subset of KRAS-mutant colon cancer cell lines are dependent upon KRAS signaling for survival. In a screen for kinases that promote survival of KRAS-dependent colon cancer cells, we found that the TAK1 kinase (MAP3K7) is required for tumor cell viability. The induction of apoptosis by RNAi-mediated depletion or pharmacologic inhibition of TAK1 is linked to its suppression of hyperactivated Wnt signaling, evident in both endogenous and genetically reconstituted cells. In APC-mutant/KRAS-dependent cells, KRAS stimulates BMP-7 secretion and BMP signaling, leading to TAK1 activation and enhancement of Wnt-dependent transcription. An in vitro-derived “TAK1-dependency signature” is enriched in primary human colon cancers with mutations in both APC and KRAS, suggesting potential clinical utility in stratifying patient populations. Together, these findings identify TAK1 inhibition as a potential therapeutic strategy for a treatment-refractory subset of colon cancers exhibiting aberrant KRAS and Wnt pathway activation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-427. doi:1538-7445.AM2012-LB-427
Clinical Consequences of Electrocardiographic Artifact Mimicking Ventricular Tachycardia
Authors: Bradley P. Knight, Frank Pelosi, Gregory F. Michaud, S. Adam Strickberger, Fred Morady
Journal: New England Journal of Medicine (1999)

Electrocardiographic artifact can simulate ventricular tachycardia. The literature regarding electrocardiographic artifact is limited to case reports,1–7 proposed classifications,8,9 and diagnostic criteria.10 There is little information regarding the clinical implications of the misdiagnosis of artifact as ventricular tachycardia. We describe 12 patients who underwent unnecessary diagnostic or therapeutic interventions as a result of such a misdiagnosis. Methods We included in this series patients who were seen in consultation by a cardiac electrophysiologist at our institution between 1995 and 1999 and who underwent a diagnostic procedure or received treatment unnecessarily, solely as a result of the misdiagnosis of artifact as . . .
Two Different 18F-FDG Brain PET Metabolic Patterns in Autoimmune Limbic Encephalitis
Authors: Ronald E. Fisher, Niraj R. Patel, Eugene C. Lai, Paul E. Schulz
Journal: Clinical Nuclear Medicine (2012)

Purpose Autoimmune limbic encephalitis (ALE) is a severe, but treatable, neuropsychiatric disorder that is difficult to diagnose clinically. With the goal of improving diagnosis of this disorder, we retrospectively evaluated the cerebral FDG PET pattern in a group of patients with ALE. Materials and Methods Nine adult patients with subacute cognitive decline were eventually diagnosed with ALE based on clinical presentation, cerebrospinal fluid inflammatory markers, and response to immunosuppressive therapy. All patients received FDG PET brain scanning during their diagnostic evaluation, which were retrospectively reviewed for this study. Results Our patients' scans fell into 2 readily separable patterns. Five younger patients had a mixed metabolic pattern most easily recognized by pronounced occipital hypometabolism, accentuated by hypermetabolism in the temporal and orbitofrontal cortex. Other, milder findings were also present. Once this unusual pattern was established as corresponding to ALE, it helped lead to the correct clinical diagnosis in the last 2 patients. Four older patients had scans that closely resembled diffuse neurodegenerative disease. Conclusions We found 2 different PET scan patterns in patients with ALE. One is an easily recognizable mixture of hyper- and hypometabolism that has also been described in a few recent case reports and is potentially specific for ALE. The other is indistinguishable from neurodegenerative disease. We propose that awareness of these patterns may contribute to the diagnosis of this elusive, but treatable, neurologic disorder.
CHILDREN'S SHOES
Authors: Edwin Matlin
Journal: JAMA (1953)

<h3>To the Editor:</h3> —Relative to the article "Children's Shoes" by Louis Starr inThe Journal(<b>151</b>:1401 [April 18] 1953), I would like to make the following comment. So far as the normal foot is concerned, either adult's or child's, the shoe is essentially a platform designed to protect the foot and to keep it off the ground. Although custom and style have determined certain changes, no shoe can be too large to fit properly. This, of course, becomes ridiculous if carried to the extreme, but the point is only a shoe that is small or that cramps or puts undue pressure on tender structures can fit poorly. As long as a youngster can wear his shoes easily and without tenderness at pressure points, his shoes fit. Persons with normal feet are comfortable in practically any shoe so long as it is large enough; those accustomed to tight-fitting and poorly-designed
Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and extracellular matrix mRNA following exposure to mineral fibers and cigarette smoke in vivo.
Authors: Y Morimoto, T Tsuda, H Nakamura, H Hori, H Yamato, N Nagata, T Higashi, M Kido, I Tanaka
Journal: Environmental Health Perspectives (1997)

To determine the effect of mineral fibers and cigarette smoke on remodeling of lung tissues, we examined matrix metalloproteinase-1 (MMP-1), MMP-2, tissue inhibitors of metalloproteinase-1 (TIMP-1), TIMP-2, and types I and IV collagen mRNA levels from rat lungs exposed to mineral fibers and/or cigarette smoke in vivo. Male Wistar rats (10 weeks of age) were given a single intratracheal instillation of 2 mg of chrysotile or alumina silicate ceramic fibers (RCF). Animals were then exposed to cigarette smoke (side stream) 5 days per week for 4 weeks. Transcriptional levels of mRNA extracted from the lungs were assessed by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Exposure to cigarette smoke induced increases in MMP-1 and TIMP-1 mRNA levels and decreased TIMP-2 and type I collagen mRNA levels in lung. Chrysotile or RCF stimulated the expression of MMP-1 mRNA in the lung. The mineral fibers and cigarette smoke had more than additive effects on the expression of MMP-2 and TIMP-1 in the lung. These data suggest that the imbalance of the expression of MMPs, TIMPs, and extracellular matrix may be associated with the remodeling of lung tissues induced by mineral fibers and/or cigarette smoke.
Abstract 4369: MMP9, MMP14, and MMP15 genes are induced by nicotine in an E2F-dependent manner
Authors: Jackie L. Johnson, Smitha Pillai, Srikumar Chellappan
Journal: Cancer Research (2010)

Abstract Cigarette smoking is strongly correlated with the onset of non-small cell lung cancer (NSCLC). Nicotine, the addictive component of cigarettes, has been found to induce proliferation, confer resistance to apoptosis, and induce EMT like changes in breast, pancreatic, and lung cancer cell lines. In addition, nicotine also induces morphological changes characteristic of a migratory, mesenchymal phenotype in NSCLCs. Correspondingly, the exact molecular mechanism for this acquired invasiveness in NSCLCs has been partially elucidated, but still remains somewhat unclear. To determine whether this increased invasion is due to up-regulation of proteolytic proteins, we first examined the mRNA levels of matrix metalloproteinase genes, which are crucial proteins for the mechanical degradation of the ECM, after exposure to nicotine. MMP9, MMP14, and MMP15 mRNA levels were significantly induced by treatment with nicotine when compared to serum starved A549 lung adenocarcinoma cells. Transient transfection experiments in H1650, A549, and MDA-MB-231 cell lines also show that a 2kb MMP9-luc promoter is induced by treatment with nicotine. In order to identify a possible factor responsible for this induction, we next analyzed the promoters of MMP genes. Chip assays show that these MMPs had multiple functional E2F binding sites. Wound healing assays on these cells showed that cells lacking E2F1 were impaired in their ability to migrate on plastic. In addition, cells lacking E2F1 showed a lower capacity for invasion, as determined by Boyden Chamber assays. The effect of depleting E2F1 on MMP expression was assessed by Real-time PCR assays. It was found that MMP 9, 14, and 15 were down-regulated in A549 cells lacking E2F1. Furthermore, these MMP9, 14, and 15 promoter reporters were induced upon co-transfection with either E2F1 or E2F3, both classical E2F activators. These data suggest that the Rb/E2F pathway is a likely downstream target of nicotine and mediates invasion by enhancing the levels of MMPs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4369.
Abstract 3836: Enhancement of doxorubicin cytotoxicity in breast cancer by NIM811, A non-immunosuppressive cyclosporine A analog
Authors: Xianke Zeng, Jiamao Zheng, Y'vonne Feeney, Katie Harrington, Charles Clevenger
Journal: Cancer Research (2012)

Abstract Cyclophilin A (CypA) is a member of the immunophilin family of peptidyl prolyl isomerases (PPI) that catalyze the cis-trans interconversion of proline imide bonds of peptides. In this role, cyclophilins have been found to function as signaling switches, regulating the activity of receptors, kinases and transcription factors. The PPI activity of CypA is inhibited by the immunosuppressive drug cyclosporine A (CsA), and in turn the CypA-CsA complex inhibits calcineurin-mediated NFAT activation. Our laboratory has demonstrated that CypA is necessary for the prolactin (PRL)-induced activation of Jak2/Stat5 signaling and gene expression (Cancer Res 68:7769, 2008). In addition, we have also shown that CsA inhibits the in vitro and in vivo growth and progression of both ER+ and ER- breast cancer cell lines. Here, we show that the non-immunosuppressive CsA analog NIM811 blocked PRL-stimulated activation of the Jak2/Stat5, PI3K/AKT and MAPK pathways in T47D cells. NIM811 also inhibited ER+, ER-, and Her2+ breast cancer cell proliferation, survival, motility and anchorage independent growth in a dose-dependent manner. NIM811 inhibited PRL induced gene expression, such as CISH and Cyclin D1. NIM811 also blocked the PRL-induced association between Stat5 and cMyb, and at higher doses, triggered PARP cleavage and activate Caspase 3. Furthermore, NIM811 increased the effects of doxorubicin in inhibiting monolayer cell growth and soft agar colony growth in vitro. In vivo, NIM811 alone significantly induced the primary tumor central necrosis and inhibited lymph node metastasis; combining NIM811 with a low dose of doxorubicin significantly inhibited MDA-MB-231 breast cancer xenograft tumor growth and distant organ metastasis. In summary, these results indicate that non-immunosuppressive cyclophilin inhibitor NIM811 has significant potential as both a single agent or in combination with cytotoxic agents for breast cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3836. doi:1538-7445.AM2012-3836
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity
Authors: Adam Collison, Luke Hatchwell, Nicole Verrills, Peter A B Wark, Ana Pereira de Siqueira, Melinda Tooze, Helen Carpenter, Anthony S Don, Jonathan C Morris, Nives Zimmermann, Nathan W Bartlett, Marc E Rothenberg, Sebastian L Johnston, Paul S Foster, Joerg Mattes
Journal: Nature Medicine (2013)
Abstract P4-06-02: Changes in intrinsic subtype of breast cancer during tumor progression in same patient
Authors: C Kim, A Kim
Journal: Cancer Research (2013)

Abstract Introduction: Hormone receptor(ER, PR), Epidermal growth factor receptor 2 (HER2) and Ki67 are important prognostic factors and key variables in classification of intrinsic subtype which is essential for selection of adjuvant therapy in breast cancer management. There have been previous reports that instability of hormonal and HER2 status during tumor progression. Recently breast cancer treatment guidelines recommended using intrinsic subtype for treatment option. Especially intrinsic subtypes were determined by using 4 immunohistochemical (IHC) assays that is ER (estrogen receptor), PR (progesterone receptor), HER2 and Ki67. The purpose of this study was to investigate whether the intrinsic subtype changes as tumor progresses from ductal carcinoma in situ (DCIS) to lymph node metastasis Methods: 90 cases of breast cancer were constructed with 2-mm core tissue microarrays (TMA). All cases simultaneously have DCIS, invasive carcinoma (IDC) and lymph node metastasis. IHC and Silver in situ hybridization (SISH) assay was performed on TMA. All of the cases after 2005 had informed consent from the patients for using their medical information and tumor tissues. Evaluation of hormone receptors expression was based on the Allred scoring method. For HER2, membranous staining was evaluated according to the guidelines of the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP). Using the results of the immunohistochemical analyses, tumors were classified into four subtypes. To define luminal A type is an ER positive and/or PR positive, HER2 negative and Ki67 low. As well as luminal B type is an ER positive and/or PR positive, HER2 positive or Ki67 high. HER2 type is HER2 positive, ER negative and PR negative and Ki67 low or high. Basal like type is classified as exhibited ER, PR, and HER2 negative. Results: Of the 90 cases, the lesions with DCIS showed 39 were luminal A, 24 were luminal B, 19 were HER2, and 8 were basal like. The lesions with IDC showed 31 with luminal A, 26 with luminal B, 23 with HER2, and 10 with basal like. Also, 28 were luminal A, 29 were luminal B, 21 were HER2, and 12 were basal like for lymph node metastasis. Overall 25% breast cancer change their intrinsic phenotype during progression. Conclusions: This study demonstrated that a subset of breast cancers can change their intrinsic subtype during cancer progression. These changes have huge impact on patient prognosis and management because each subtype have own different optimized treatment options according to St Gallen and NCCN guideline. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-06-02.
Heterogeneous telomere defects in patients with severe forms of dyskeratosis congenita
Authors: Fabien Touzot, Laetitia Gaillard, Nadia Vasquez, Tangui Le Guen, Yves Bertrand, Jean Bourhis, Thierry Leblanc, Alain Fischer, Jean Soulier, Jean-Pierre de Villartay, Patrick Revy
Journal: Journal of Allergy and Clinical Immunology (2011)
Abstract 92: dbCPCO: The database of genetic predictive and prognostic factors in colorectal cancer
Authors: Sevtap Savas, Ban Younghusband
Journal: Cancer Research (2010)

Abstract Introduction: Colorectal cancer is the third most common cancer in the North America with a 5-year survival rate of ∼65%. A portion of the inter-patient variability in disease outcome in colorectal cancer patients is attributed to inherited and somatic genetic factors. Identification of these genetic factors helps implementing personalized medicare to improve the chances of cure in patients. While numerous research articles have investigated the genetic basis of clinical outcome in colorectal cancer, there has not been a central resource, such as a public database, that compiles these findings in a systematic, comprehensive and concise way. Here we describe the dbCPCO, a database of genetic factors investigated in relation to clinicopathological characteristics and clinical outcome (i.e. treatment response and toxicity, prognosis and survival) in colorectal cancer. Methods: Literature reports were retrieved from PUBMED. The data that met the inclusion criteria were compiled in a relational database and posted in a dedicated website. Results: The genetic factors included the inherited genetic polymorphisms, somatic and germline mutations in both nuclear and mitochondrial DNA. As of November 2009, the dbCPCO website posts 610 scientific findings on &amp;gt;300 polymorphisms, somatic and germline mutations from 146 genes tested for correlation with clinicopathological and/or clinical outcome in colorectal cancer. Conclusion: The dbCPCO is a unique and comprehensive database that compiles literature findings on the genetic basis of disease phenotype and clinical outcome in colorectal cancer and will be instrumental in expediting personalized medicine and further research in this disease. The dbCPCO is updated periodically and is freely available for the scientific and medical community at http://www.med.mun.ca/cpco/Default.aspx. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 92.
Minimal Incision Extraction of Lipomas
Authors: Michael T. Cosulich, Matthew A. Molenda, Eliot Mostow, Ashish C. Bhatia, Robert T. Brodell
Journal: JAMA Dermatology (2014)

nail fold or matrix.Pushing a plastic gutter between the nail edge and the ulcer bed is all that is necessary and usually does not require anesthesia.In our experience, cyanoacrylate glue offers more security and stability than suturing or other methods for attaching the gutter.This approach is more effective, easy to perform, more acceptable to patients, and less traumatic than classical gutter technique.It can be considered an initial treatment for most patients with mild ingrown toenail.However, this conservative method may not be the first choice for cases with soft-tissue overgrowth or extensive granulation tissue.