tbuckley/cabot-search huggingface dataset:
Immunologic tests of specific antibodies to organic acid anhydrides
Authors: H. Welinder, J. Nielsen
Journal: Allergy (1991)

The outcome of immunologic tests of antibodies directed against hapten conjugates of organic acid anhydrides and human serum albumin (HSA) has been studied in workers exposed to phthalic anhydride (PA), methyltetrahydroplithalic anhydride (MTHPA), hexahydrophthalic anhydride (HHPA), and methylhexahydrophthalie anhydride (MHHPA). HSA conjugates of PA, MTHPA, HHPA, MHHPA, and nialeic anhydride (MA) have been prepared and used in the tests. The hapten densities (HD) of the conjugates were varied by different molar ratios of hapten and macromolecule in the preparative procedure. Skin prick reactions to MTHPA‐HSA increased with rising HD over the range 6‐13 mol/mol. The achieved HD was tested by spectrometric and gas chromatographic methods. In RAST of IgE antibodies MTHPA‐HSA with HD six and 25 showed significantly lower bindings than conjugates with intermediate HD. There was a good correlation between skin prick tests and RAST. Of 234 workers tested [MTHPA ( n = 145), and HHPA ( n = 89)], 45 had a skin prick reaction &gt; 50% of the histamine reaction (1 mg/ml). All but two of these were RAST positive (RAST value &gt; 0.3%; 0.3% upper range in 147 controls; MTHPA, n = 63; HHPA, n = 84). Nine RAST positive workers had no obvious skin prick reaction. However, their RAST values were low (&lt;0.8%). In exposed workers, the ELISA value of specific IgG antibodies to MTHPA‐HSA showed optimal values when tested with the HD 13 conjugate. The specific antibodies in workers exposed to either MTHPA or HHPA/MHHPA showed a marked cross‐reactivity to MTHPA‐HSA, HHPA‐HSA, and MHHPA‐HSA as proven by skin prick tests, RAST, and RAST inhibition. In workers exposed lo PA (here was less cross reactivity to the other anhydrides.
Prevention of Infection In Peritoneal Dialysis
Authors: Jacob Fine
Journal: JAMA (1967)

To the Editor:—  In the communication Prevention of Infection During Dialysis, Schwartz et al ( 199 : 79, 1967) point to the intestinal tract as the source of bacteria which contaminate the peritoneum during dialysis for the treatment of renal insufficiency, and to the effectiveness of orally administered neomycin and brief intermittent periods of dialysis to avoid or reduce the incidence of peritonitis.  The authors refer to our initial study of peritoneal dialysis ( 120 : 703, 1964) in which we were concerned with bacterial contamination of the peritoneum from the irrigation fluid and the openings in the abdominal wall. But our subsequent experimental and clinical studies ( Ann Surg  124 :857, 1946; Ann  Surg  128 :561, 1948; New Eng J Med  242 :747, 1950; and J Clin Invest  25 :747, 1950) demonstrated that bacterial contamination that occurs in the absence of invasion via the catheter, irrigation fluid, or the abdominal incision is caused by
Abstract 2502: Proteomic identification of carboplatin resistance in ovarian cancer cells.
Authors: Kazimierz O. Wrzeszczynski, Gaofeng Fan, Cexiong Fu, Darryl J. Pappin, Robert Lucito, Nicholas K. Tonks
Journal: Cancer Research (2013)

Abstract The analysis of quantitative protein expression is necessary for the determination of actual biochemical protein concentrations that can lead to a more accurate description of cellular function. A knowledgebase of cancer function based on cellular protein levels can more directly implicate potential gene candidates for the detection and treatment of disease. Therefore, we analyzed iTRAQ (isobaric tag for relative and absolute quantification) data from 11 serous ovarian cancer cell lines and 2 normal ovarian surface epithelial cell lines. We profiled cellular protein abundance in over 3000 proteins with 749 proteins common to all 13 cell lines. Of the 749, 52 proteins exhibited elevated expression and 46 proteins had diminished expression in the cancerous cells when compared to the normal cell lines. We identified the 300 most variable iTRAQ expressed proteins based on median absolute deviation within 8 carboplatin sensitive and resistant cell lines. Using iTRAQ protein expression profiles from these 300 we successfully segregated the cell lines based on carboplatin sensitivity and resistance measurements. We further examined correlations among iTRAQ protein expression, individual gene RNA expression and DNA methylation data. There was no substantial correlation between protein abundance and RNA expression or epigenetic data. Furthermore RNA expression and DNA methylation data alone did not show any significant discrimination for chemosensitivity or resistance. We therefore present the potential of proteomics based discovery for carboplatin response in ovarian cancer and also identify putative gene candidates that may be functionally responsible for chemotherapy response which otherwise would not have been predicted using other singular whole genome data sources. Citation Format: Kazimierz O. Wrzeszczynski, Gaofeng Fan, Cexiong Fu, Darryl J. Pappin, Robert Lucito, Nicholas K. Tonks. Proteomic identification of carboplatin resistance in ovarian cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2502. doi:10.1158/1538-7445.AM2013-2502
Androgenic Hormone Therapy in Lymphatic Leukemia
Authors: B. J. Kennedy
Journal: JAMA (1964)

ANEMIA may occur during the course of chronic lymphatic leukemia. The study of erythrokinetics has revealed that the development of this anemia may be due to decreased erythropoiesis with normal or increased red blood cell destruction or loss. There is little understanding of the reason for the failure of leukemic marrow to provide adequate erythropoiesis. A metabolic competition between developing red blood cells and pathological white cells has been suggested.<sup>1</sup>Because of the stimulation of erythropoiesis produced by androgenic hormones, androgens were administered to patients with lymphatic leukemia. In patients with advanced breast cancer, androgenic hormones produced reticulocytosis, normoblastic hyperplasia of the bone marrow, and an increase in hemoglobin even to polycythemic values (Fig 1).<sup>2,3</sup>Because of these observations, androgens were employed in the treatment of a variety of anemias.<sup>3-5</sup>Improvements were noted in aplastic anemia, refractory anemia, myelofibrosis, and various diseases with erythroid hypoplasia. During a
EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy
Authors: Hung-Wei Yang, Yu-Jen Lu, Kun-Ju Lin, Sheng-Chieh Hsu, Chiung-Yin Huang, Shu-Han She, Hao-Li Liu, Chih-Wen Lin, Min-Cong Xiao, Shiaw-Pyng Wey, Pin-Yuan Chen, Tzu-Chen Yen, Kuo-Chen Wei, Chen-Chi M. Ma
Journal: Biomaterials (2013)
Universal Screening for Methicillin-Resistant &lt;emph type="ital"&gt;Staphylococcus aureus&lt;/emph&gt; by Hospitals
Authors: Rosemary Harris
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does the choice between Tc-99m tetrofosmin and Tc-99m sestamibi influence exercise-induced myocardial perfusion defect size and reversibility?
Authors: M. Ferraro-Borgida, A.W. Ahlberg, M.G. Levine, M.R. Mansoor, C.C. McGill, G.M. Cyr, J.M. Phillips, D.A. Clapp, D. Waters, G.V Heller
Journal: Journal of the American College of Cardiology (1998)
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein
Authors: Julian Borrow, Vincent P. Stanton, J. Michael Andresen, Reinhard Becher, Frederick G. Behm, Raju S. K. Chaganti, Curt I. Civin, Christine Disteche, Ian Dubé, Anna Marie Frischauf, Doug Horsman, Felix Mitelman, Stefano Volinia, Ann E. Watmore, David E. Housman
Journal: Nature Genetics (1996)
Bile acid metabolism and biliary secretion in patients receiving orthotopic liver transplants: Differing effects of cyclosporine and FK 506
Authors: Timothy M. McCashland, Jeremiah P. Donovan, Andree Amelsberg, Steven S. Rossi, Alan F. Hofmann, Byers W. Shaw, Eamonn M. M. Quigley
Journal: Hepatology (1994)

Bile acid metabolism and biliary secretion were characterized in the first 2 wk after orthotopic liver transplantation in 15 patients receiving cyclosporine and in five patients receiving FK 506. Analyses were performed on hepatic bile obtained by T-tube drainage; values obtained were compared with literature values for bile samples obtained in patients who had undergone cholecystectomy. Biliary bile acid output, which is equivalent to bile acid biosynthesis from cholesterol, was low (mean +/- S.E.M.) and increased with time: day 1, 0.50 +/- 0.1 mmol/day; day 3, 0.8 +/- 0.1 mmol/day; and day 6, 1.6 +/- 0.5 mmol/day. Chenodeoxycholic acid biosynthesis, as percent of total bile acid biosynthesis, was abnormally low in patients receiving cyclosporine (16.2 +/- 1.1) but not in patients receiving FK 506 (38.2 +/- 4.8) (p < 0.005). Before the T-tube was clamped, the proportion of deoxycholic acid (a secondary bile acid formed by bacterial 7-dehydroxylation of cholic acid) was low in both groups: cyclosporine, 0.4 +/- 0.1; FK 506, 4.8 +/- 2.5 (p < 0.01). The mean concentration of bile acids in hepatic bile between days 4 and 11 did not differ significantly between groups: cyclosporine, 7.7 +/- 1.3 mmol/L; FK 506 4.3 +/- 0.7 mmol/L (mean +/- S.E.M.). (These values are similar to those reported for patients who have undergone cholecystectomy.) Bile acid-dependent bile flow, expressed as apparent choleretic activity (microliters of bile per micromole of bile acid output), was markedly elevated: in patients receiving cyclosporine the value was 129, and in patients receiving FK 506 the value was 220. (In patients who have undergone cholecystectomy, this value is less than 30).(ABSTRACT TRUNCATED AT 250 WORDS)
Quinidine Lactate and Gluconate in the Suppression of Ectopic Ventricular Tachycardias Associated with Myocardial Infarction
Authors: A. SIDNEY HARRIS, ANTONIO ESTANDÍA, TEDROE J. FORD, REX F. TILLOTSON
Journal: Circulation (1951)

In dogs with myocardial infarction, produced by a standard technic, rapid persistent ectopic ventricular tachycardia develops. Intravenous quinidine lactate and quinidine gluconate effectively control the arrhythmia in 56 to 60 per cent of the animals, but produce toxic reactions in many of them. Morphine sulfate prevents vomiting and diarrhea from quinidine, but does not prevent convulsive movements. The most effective treatment of the arrhythmia was by use of morphine followed by quinidine gluconate. This combination was successful in 89 to 100 per cent of the cases. Principles for guidance in the treatment of severe ventricular arrhythmias have been drawn from these studies.
Treatment of Dieulafoy’s lesion of the right colon with epinephrine injection and argon plasma coagulation
Authors: J. Souza
Journal: Endoscopy (2009)

Dieulafoy's lesion is a tiny submucosal defect overlying an artery in the muscularis mucosa [1]. Dieulafoy's lesion of the colon is a rare cause of lower gastrointestinal bleeding [2].
Allergens of <i>Epicoccum nigrum</i> grown in different media for quality source material
Authors: V. Bisht, B. P. Singh, N. Arora, S. Sridhara, S. N. Gaur
Journal: Allergy (2000)

Background: The Epicoccum nigrum (EN) extract used in allergy disorders exhibits batch‐to‐batch variations in protein composition and allergenic potency. In this study, the allergens of EN grown in different media were investigated. Methods: EN was grown in five different nutrient media as stationary cultures at 25°C for 5–23 days. The growth pattern was characterized by measuring dry weight, and protein and carbohydrate content. The antigenic and allergenic content of EN extract was evaluated with EN‐positive patients' sera and antibodies raised in rabbit. Results: The growth of EN in Czapeck Dox medium yielded insufficient material, while Sabouraud's broth with yeast extract (SBY) gave maximum spore‐mycelial mass and protein content. Potato dextrose broth (PDB) and potato dextrose agar (PDA) showed higher dry weight and protein in 7–9‐day cultures. SDS–PAGE resolved 26, 22, and 21 protein bands in EN extracts from cultures of day‐13 SBY, day‐7 PDB, and day‐9 PDA, respectively. IgE/IgG immunoblots showed more allergenic ( 25 )/antigenic ( 25 ) bands in EN cultured in SBY than in the others. Specific IgE ELISA and intradermal tests showed EN extract from day‐13 culture in SBY to be the most potent. Conclusions: The day‐13 culture of EN in SBY was the most potent and may be selected for preparing EN extracts for diagnosis of allergy and future studies.
Bundle-branch Block in Acute Myocardial Infarction
Authors: D. Hunt, G. Sloman
Journal: BMJ (1969)

Bundle-branch block was present in 41 out of 415 patients admitted to a coronary care unit with acute myocardial infarction and was associated with more severe clinical infarction and an overall mortality of 56%. It is probable that permanent bundle-branch block develops soon after infarction and that most of the patients with permanent block have had clinically severe infarction. Bundle-branch block developing during observation is usually transient, and the later it develops the sooner it resolves. Analysis of the arrhythmias and clinical course of the patients suggests that those with bundle-branch block and shock and those in whom bundle-branch block is present on admission may benefit from the use of a demand pacemaker attached to a transvenous pacemaker catheter, though the dividends of pacing may be small and the risks of the procedure significant. Post-mortem examination of 17 hearts showed extensive infarction, usually involving the septum, and severe coronary artery disease.
Gastroenterological practice in Israel.
Authors: D Rachmilewitz
Journal: Gut (1994)

The practice of gastroenterology in Israel has changed greatly in the past two decades with the revolution in the profession that came along with the development of fibreoptic endoscopy.Some of the benefits and problems this change has made are shared worldwide.Family physicians have direct referral channels for upper gastro- intestinal endoscopy or colonoscopy for their patient without preliminary consultation with a gastroenterologist.This direct access has led to over utilisation of existing diagnostic services that, at times, have difficulty in performing all that is requested without long delays.Recent studies have also shown, not unexpectedly, that a significant number of the procedures performed were not indicated.The financial burden induced by the explosion
Crisis in General Practice
Authors: William W. Shacklett
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Dr. Foster expresses the feelings and desires of most general practitioners. It is true that general practice is at a crossroads. Its future is definitely jeopardized by the feelings implied and expressed by the medical specialties, government agencies, and insurance companies. If something is not done to establish and maintain the needed and earned reputation, this field-line practice of medicine is doomed. Educating this group of physicians to practice good medical care will give the general public what it needs and wants: family physicians who are interested in individuals as individuals, in people as people, and in the general social welfare of the country. If we improve the status of this group in the public eye, and establish in our medical schools a stimulus to place this field on an equal footing with other fields, success will be obtained. We need to encourage young men to practice
CASE HISTORY AND PHOTOGRAPH.
Authors: B. MERRILL RICKETTS
Journal: JAMA (1900)

in his hand like a pen.Almost all catelectrolytic oper- ations can be performed with a so-called jeweler's broach.In exceptional cases a sewing needle of very fine caliber may be substituted.The broach or needle is made to pierce into the tissue, or is introduced into a follicle, and then the patient is directed to close the
Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations
Authors: Daniel T. Starczynowski, Ryan Morin, Andrew McPherson, Jeff Lam, Raj Chari, Joanna Wegrzyn, Florian Kuchenbauer, Martin Hirst, Kaoru Tohyama, R. Keith Humphries, Wan L. Lam, Marco Marra, Aly Karsan
Journal: Blood (2010)
Retinopathy of Prematurity
Authors: Dale L. Phelps
Journal: New England Journal of Medicine (1992)

Retinopathy of prematurity was first described in 1942,1 and during the ensuing decade it occurred predominantly in the most modern nurseries, raising the suspicion that it might be an iatrogenic disease.2 By 1956 one of the first randomized, multicenter trials ever performed had demonstrated that if premature infants who did not have lung disease breathed oxygen at a concentration higher than 50 percent for four weeks, their risk of retrolental fibroplasia (as retinopathy of prematurity was then called) increased three-fold.3 It was a bitter irony that lifesaving oxygen therapy could cause blindness. Silverman has estimated that during that decade close . . .
Penicillin for Haemolytic Streptococcal Throat Infections
Authors: P. Robinson
Journal: BMJ (1945)

had no adverse effect.Ampoules containing 1 c.cm. of semen were therefore vitrified at -196°C.or -79°C.and maintained at the latter temperature for 2 days and 8 days.In each case thawing out showed that an abundance of spermatozoa had survived.A long-term experiment has now been set up, but in view of the work of Jahnel and of Shettles it is fairly certain that under optimum conditions large numbers of human sper- matozoa will survive prolonged vitrification.A much more important and doubtful point is whether vitri- fication affects the power of the spermatozoon to fertilize and activate the egg and induce normal embryonic development.In the experiments on fowl spermatozoa, quoted above, normal development was not induced after freezing for 1 hour at -79°C., but the partial dehydration before vitrification may have affected their genetic properties.The question is of great interest.Artificial insemination of humans will no doubt be- come increasingly common, and the elaboration of a method permitting of prolonged storage and transport of the semen without affecting the genetic properties of the spermatozoa would open up remarkable possibilities.It is not obvious how the problem of genetic modification is to be investigated with human material, and it is unfortunate that the sperma- tozoa of laboratory mammals, including those of the Rhesus monkey, are killed by vitrification under any conditions so far investigated.Summary A large propor-tion of human spermatozoa survive for long periods in semen frozen in bulk at 196°C.or -79°C.Spermatozoa do not survive when minute amounts of semen are frozen as films or in fine capillary tubes.The rate of freezing and thawing is not the primary factor in the survival of human sper-matozoa exposed to low temperatu-es.I am much indebtzd to Dr. P. M. F. Bishop, Guy's Hospital, for making arrangements with the donors.
A multicenter study on the role of direct retrograde cholangioscopy in patients with inconclusive endoscopic retrograde cholangiography
Authors: Harald Farnik, Jochen Weigt, Peter Malfertheiner, Angela Grützmann, Liebwin Gossner, Mireen Friedrich-Rust, Stefan Zeuzem, Christoph Sarrazin, Jörg Albert
Journal: Endoscopy (2013)

<b>Background and study aims:</b> Direct retrograde cholangioscopy (DRC) may improve the diagnostic and therapeutic yield of endoscopic retrograde cholangiography (ERC) but safety, feasibility, and outcome are unknown. <b>Patients and methods:</b> All consecutive patients who underwent DRC at three tertiary endoscopy centers for inconclusive findings at ERC were included in this retrospective analysis. Ultraslim endoscopes (FujiFilm EG 530NP; Olympus GIF XP180; GIF N180) were used by the peroral route for intubating all accessible bile ducts. Success rate, usefulness in diagnosis and therapy, and safety of DRC were assessed in terms of technical and clinical parameters and therapeutic vs. diagnostic indication. <b>Results:</b> DRC was performed in 130 cases (89 patients). CO<sub>2</sub> insufflation and an anchoring balloon were used in 66.9 % and 97.7 % of cases, respectively. Intubation of the papilla was successful in 115 of 130 (88.5 %) cases, and the aim of the DRC investigation was accomplished in 105 cases (80.8 %). DRC-guided biopsies were taken in 53 cases (40.8 %), and a therapeutic intervention was performed in 32 cases (24.6 %). The initial diagnosis was revised by DRC in 18 of 69 patients (26.1 %) with indeterminate biliary stricture. Complications were observed in 10 cases (7.7 %), including cholangitis (n = 2; 1.5 %), bleeding (n = 2; 1.5 %), and pain, hypoxia, bradyarrhythmia, air embolism, and perforation of an intrahepatic and an extrahepatic bile duct (1 each; 0.8 %). There was no mortality associated with DRC. <b>Conclusions:</b> DRC was successfully performed for the diagnosis and treatment of biliary disease that had eluded diagnosis with conventional ERC. DRC impacted on clinical decision making. The complication rate was low and similar to other cholangioscopy techniques.
Patients with suspected Lassa fever in London during 1984
Authors: R Fryatt, A D Harries, A. Hall
Journal: BMJ (1986)

succession of withdrawals of non-steroidal antiinflammatory drugs, including several of the most recently introduced and best tested products.The supporting evidence for withdrawal has not been published, but the decisions seem to have been based on yellow cards or journal anecdotes.Such reports are useful for generating hypotheses about possible risks but are of practical value only when the events reported are very rare or unusual.NHS data cannot be used to provide estimates for the number of patients who might be at risk from adverse reactions.For example, 12 000 pre- scriptions could provide a month's supply for 12 000 patients or a year's supply for 1000.Some of the non-steroidal anti-inflammatory drugs, such as indomethacin, have been used by many patients for up to 20 years, while others, such as piroxicam, have been available for five years or less.The authors cannot distinguish short term from long term use among their patients or distinguish between individuals whose ulcers were caused by non-steroidal anti-inflammatory drugs and those whose ulcers would have occurred spontaneously.They have no estimate of the number of patients at risk.Neither their data nor those from the CSM which they quote are suitable for comparing the safety or dangers of non-steroidal anti-inflammatory drugs.