tbuckley/cabot-search huggingface dataset:
GMC clears former BMA chairman of misconduct
Authors: C. Dyer
Journal: BMJ (2010)

Jim Johnson, former chairman of the BMA, has been cleared of misconduct by the General Medical Council after an 11 week hearing into a catalogue of charges involving 14 patients.

A fitness to practise panel decided that his professional performance as a vascular surgeon had been deficient in some respects, mainly with regard to operating techniques, postoperative care of patients, and failure to attend multidisciplinary meetings ( BMJ 2010;341:c6667, doi:10.1136/bmj.c6667). But the deficiencies had been remedied and his fitness to practise was not impaired, the panel held.

Mr Johnson, a consultant surgeon at North Cheshire Hospitals NHS Trust, was …
Suppose We Die Young, Late in Life?
Authors: Frank Matthews
Journal: JAMA (1978)

<h3>To the Editor.—</h3> As a child I heard often that "if wishes were horses, beggars would ride." It was therefore with a disturbing sense of déjà vu that I read the COMMENTARY "Suppose We Died Young, Late in Life...?" by Wynder and Kristein. First, the medical profession is urged to begin work now on "reducing preventable chronic disease, eg, lung cancer, cancer of the upper alimentary tract, chronic bronchitis, coronary heart disease, cirrhosis of the liver, and emphysema." True, if the populace would stop smoking, cut down on drinking, avoid overeating, and get more exercise, we would see far less of these diseases. For years every clinician I know has been urging these steps for his patients. Yet as free Americans we insist on what some have called our constitutional right to be damned fools; improvement of these habits will require far more drastic powers than physicians are likely to
Effects of Music on Cardiovascular Reactivity Among Surgeons
Authors: Karen Allen
Journal: JAMA (1994)

To determine the effects of surgeon-selected and experimenter-selected music on performance and autonomic responses of surgeons during a standard laboratory psychological stressor.Within-subjects laboratory experiment.Hospital psychophysiology laboratory.A total of 50 male surgeons aged 31 to 61 years, who reported that they typically listen to music during surgery, volunteered for the study.Cardiac responses, hemodynamic measures, electrodermal autonomic responses, task speed, and accuracy.Autonomic reactivity for all physiological measures was significantly less in the surgeon-selected music condition than in the experimenter-selected music condition, which in turn was significantly less than in the no-music control condition. Likewise, speed and accuracy of task performance were significantly better in the surgeon-selected music condition than in the experimenter-selected music condition, which was also significantly better than the no-music control condition.Surgeon-selected music was associated with reduced autonomic reactivity and improved performance of a stressful nonsurgical laboratory task in study participants.
Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)–rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study
Authors: Georg Mann, Andishe Attarbaschi, Martin Schrappe, Paola De Lorenzo, Christina Peters, Ian Hann, Giulio De Rossi, Maria Felice, Birgitte Lausen, Thierry LeBlanc, Tomasz Szczepanski, Alina Ferster, Gritta Janka-Schaub, Jeffrey Rubnitz, Lewis B. Silverman, Jan Stary, Myriam Campbell, Chi Kong Li, Ram Suppiah, Andrea Biondi, Ajay Vora, Maria Grazia Valsecchi, Rob Pieters
Journal: Blood (2010)
Coroner calls for ban on junior doctors working unsupervised at night
Authors: H. Barnett
Journal: BMJ (2014)

A coroner has called for a ban on junior doctors working alone on night shifts, after a woman’s death at Basildon Hospital uncovered “woefully inadequate” care.

Lyn O’Reilly, 57, contracted a fatal infection after a bowel operation, and senior consultants missed the infection. Over the 2012 August bank holiday weekend she was put under the care of junior doctors who had been in the job for only four weeks. One junior doctor was caring for 130 patients alone during a night shift.

On 31 …
Maintenance Treatment of Major Depression in Old Age
Authors: Charles F. Reynolds, Mary Amanda Dew, Bruce G. Pollock, Benoit H. Mulsant, Ellen Frank, Mark D. Miller, Patricia R. Houck, Sati Mazumdar, Meryl A. Butters, Jacqueline A. Stack, Mary Ann Schlernitzauer, Ellen M. Whyte, Ariel Gildengers, Jordan Karp, Eric Lenze, Katalin Szanto, Salem Bensasi, David J. Kupfer
Journal: New England Journal of Medicine (2006)

Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death.
The Likelihood Ratio and Diagnostic Tests
Authors: Randall D. Cebul
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 June 1986The Likelihood Ratio and Diagnostic TestsRANDALL D. CEBUL, M.D.RANDALL D. CEBUL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-888_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Those of us who use probabilistic reasoning in our approaches to patient care welcome the series of articles introduced by Dr. Sox in the January issue (1). Although far more is known about these quantitative approaches than could be introduced in Dr. Sox's brief review, I want to draw attention to a somewhat misleading definition of the "likelihood ratio"for a diagnostic test result—sensitivity/(1—specificity)—that appeared in the glossary.The likelihood ratio expresses the odds that a given level of test abnormality would be expected in patients with the disease under consideration. Specifically, the likelihood ratio contrasts the proportion...References1. SOX H. Probability theory in the use of diagnostic tests: an introduction to critical study of the literature. Ann Intern Med. 1986;104:60-6. LinkGoogle Scholar2. HULL R, HIRSH J, and CARTER C. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Ann Intern Med. 1983;98:891-9. LinkGoogle Scholar3. SACKETT D, HAYNES R, and TUG WELL P. Clinical Epidemiology: A Basic Science for Clinical Medicine. Boston: Little, Brown & Company; 1985. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RANDALL D. CEBUL, M.D.Affiliations: University of Pennsylvania Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEstimating Confidence intervals of Likelihood RatiosThe Single-cutoff Trap 1 June 1986Volume 104, Issue 6Page: 888-889KeywordsLikelihood ratioPatientsReasoning ePublished: 1 December 2008 Issue Published: 1 June 1986 PDF downloadLoading ...
Abstract 1410: Gnaq/11 mutant uveal melanoma is susceptible to Brd4 inhibition by JQ1
Authors: Grazia Ambrosini, Gary K. Schwartz
Journal: Cancer Research (2014)

Abstract Uveal melanoma (UM) represents the most common intraocular malignancy in the United States, and there are no effective treatments for this aggressive disease. Uveal melanoma is characterized by oncogenic mutations in Gnaq and Gna11, which activate the mitogen-activated protein kinase pathway (MAPK). Furthermore, both primary and metastatic UM are characterized by genetic abnormalities, including the amplification of the chromosomal arm 8q and monosomy of chromosome 3, which are significantly associated with poor prognosis. The oncogene MYC, which is located on 8q24.1, is amplified in nearly 70% of uveal melanoma, and is also regulated by the MAPK pathway. Chromatin regulators have become attractive targets for cancer therapy. In particular, the BET-bromodomain inhibitor JQ1 has shown selective inhibition of c-Myc expression, followed by the suppression of c-Myc-dependent target genes. We examined the effects of JQ1 in a panel of 8 UM cell lines, including cell lines with Gnaq/Gna11 mutations (92.1, Omm1.3, Mel270, Mel202, Omm1), a cell line with MYC amplification (Mel290), and cells without either mutation or amplification (C918, Mel285). The Gnaq/Gna11 mutant cells were the most sensitive to growth inhibition at nanomolar concentrations of JQ1 (IC50=200nM), followed by the cell line with amplified MYC (IC50=1μM), while the cells without mutation or amplification exhibited little inhibition. We also examined the biochemical effects of JQ1 treatment, which caused a dose- and time-dependent suppression of c-Myc as well as survivin, XIAP, ERK1 and E2F1, while p21and the pro-apoptotic protein Bim were induced in all the cell lines. Interestingly, JQ1 also suppressed the anti-apoptotic protein Bcl-xL and induced PARP cleavage only in the Gnaq/Gna11 mutant cells. Flow cytometric analysis indicated a cell cycle arrest in G1 in all the cell lines and an apoptotic population in sub-G1in the mutant cells. Furthermore, treatment with JQ1 resulted in significant antitumor activity in mouse xenograft models of uveal melanoma with Gnaq mutation. All together, these observations support the evidence that JQ1 represent a promising therapeutic approach for uveal melanoma with Gnaq/Gna11 mutations. Citation Format: Grazia Ambrosini, Gary K. Schwartz. Gnaq/11 mutant uveal melanoma is susceptible to Brd4 inhibition by JQ1. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1410. doi:10.1158/1538-7445.AM2014-1410
Endoscopic Papillary Balloon Dilation for Bile Duct Stone: Immediate and Long-Term Outcomes in 1000 Patients
Authors: Takeshi Tsujino, Takao Kawabe, Yutaka Komatsu, Haruhiko Yoshida, Hiroyuki Isayama, Takashi Sasaki, Hirofumi Kogure, Osamu Togawa, Toshihiko Arizumi, Saburo Matsubara, Yukiko Ito, Yousuke Nakai, Natsuyo Yamamoto, Naoki Sasahira, Kenji Hirano, Nobuo Toda, Minoru Tada, Masao Omata
Journal: Clinical Gastroenterology and Hepatology (2007)
Unlicensed to heal
Authors: Naomi Marks
Journal: BMJ (2005)

How did an advertisement for a so called psoriasis “remedy” get accepted by several national newspapers? 

C ashmere Beauty is a “new unisex organic cream,” which, according to advertisements that have appeared recently in three UK national broadsheets, offers “an effective alternative to toxic prescriptive products treating Psoriasis, Eczema or any irritated complexion.” The advertisement, headlined “Psoriasis & eczema remedy discovered,” also claimed that Cashmere Beauty “heals effected [sic] skin, including: scar tissue, bumps, mild acne and stretch marks.” It further claimed the product was “dermatologically tested and FDA approved.”

To find out more, readers were urged to visit Cashmere Beauty's website (http://www.cashmerebeauty.com/), where they could learn that the cream is made from fresh (“not powdered”) cashmere goats' milk and ponder the prices of The Miracle Bar (£10) and a 30 ml pot of the Rapid Recovery Cream (£34.50).

Now the UK Advertising Standards Authority (ASA) is investigating whether or not the advertisement, which appeared in the Times , the Independent , and the Guardian , falls foul of its code.

A quick Google search shows that before the ad's …
Trends in adoption of Wingspan stents
Authors: A. Gupta, H. Krumholz
Journal: BMJ (2014)

Two recent BMJ articles have criticised the US Food and Drug Administration for approving the Wingspan stent used for intracranial stenting (ICS) to prevent recurrent stroke despite insufficient evidence of its effectiveness.1 2 They also draw attention to the FDA’s inadequate response to recent evidence from the SAMMPRIS randomised controlled trial against the use of ICS in these patients.

We share …
Suffocation from misuse of gas masks during the Gulf war.
Authors: J. Hiss, B. Arensburg
Journal: BMJ (1992)

Unfortunately, because the safety ofprolonged courses of fluoroquinolones has not been established they cannot be recommended for treating leprosy.Minocycline, however, has been used for over two decades, primarily for other bacterial diseases and acne; because of its safety record in long term use our findings strongly support its application to the treat- ment of leprosy.Minocycine may also be a second bactericidal agent to combine with rifampicin treatment and thereby shorten the duration of treatment required to treat leprosy effectively.
Special Book Review
Authors: Marjorie C. Meehan
Journal: JAMA (1970)

When some unusual bones, almost but not quite those of modern man, were found in the Neanderthal, near Düsseldorf, a few investigators believed them to be from an extinct type of human. But this was 1856 and few people, even scientists, were willing to consider that the human race did not start with Adam. Various explanations of the bones were offered—eg, they were from an idiot with rickets and a bad disposition —the flat forehead and heavy brows were caused by blows to the head. Three years later, Darwin's<i>Origin of Species</i>appeared and the controversy about evolution exploded. By the time most scientists accepted the concept of evolution, other ancient bones resembling those from Neanderthal were found elsewhere and Neanderthal man was accepted as one of our predecessors. Darwin's view, popularly interpreted as "we were descended from monkeys," led to the search for "the missing link" between monkey and
Anticardiolipin antibodies in rheumatoid arthritis: their relation to rheumatoid nodules and cutaneous vascular manifestations
Authors: P. WOLF, J. GRETLER, F. AGLAS, P. AUER-GRUMBACH, F. RAINER
Journal: British Journal of Dermatology (1994)

One hundred and seventy-three consecutive patients with rheumatoid arthritis were examined for the presence of anticardiolipin antibodies (ACA), and for the clinical relevance and the relation of these antibodies to skin manifestations. Abnormally elevated IgG- and/or IgM-ACA levels were detected by an enzyme-linked immunosorbent assay in the sera of 55 (32%) patients. There was no statistical evidence of an association between ACA and a history of thrombosis in these patients. However, ACA were statistically significantly linked to the presence of rheumatoid nodules, which were found in 36 (21%) patients. In three patients, ACA were associated with vascular manifestations, including livedo reticularis, thrombophlebitis, and leucocytoclastic vasculitis. Our findings suggest that, although a subset of ACA may be linked to cutaneous vascular conditions, the major fraction of ACA in rheumatoid arthritis may have a different specificity than in other diseases, in which ACA are often linked to thrombotic events.
Genetic structure of the population with rheumatoid arthritis in north east England: a genetic approach to define different subtypes.
Authors: S.S Papiha, J.S Lanchbury, B Pal
Journal: Annals of the Rheumatic Diseases (1986)

Clinically and immunologically rheumatoid arthritis (RA) is possibly a heterogeneous disorder. Despite numerous efforts clearer definition of this heterogeneity has been of limited success. Measurements of rheumatoid factor (RF) and antinuclear antibodies (ANA) by conventional methods define subpopulations of patients with RA and in a few recent studies an association of human leucocyte antigens (HLA) undoubtedly indicates the immunogenetic differences in the susceptibility of RA patients with different status of autoantibodies. The studies on a few isolated non-HLA genetic markers in RA are controversial. To understand the role of genetic factors in susceptibility 24 single gene characters other than HLA were investigated in 225 patients with RA classified by humoral status (presence or absence of RF and ANA) into three groups and in 104 healthy control individuals from the north east of England. Locus by locus comparison suggested associations of MN, Lewis, and Bf system with RF positive patients. Although the associations with MN and Lewis blood groups require further investigations, the involvement of the Bf locus is in agreement with the immunological component of the disease suggested by HLA associations and it could be due to the phenomenon of linkage disequilibrium. Measures of genetic distance applied to the subpopulations of patients with RA, divided according to the presence or absence of humoral factors, suggest that RF+ ANA+, RF- ANA-, and RF+ ANA- subgroups are distinct genetic diseases, each affecting a different subsection of the population which is genetically distinct. Such genetic heterogeneity may suggest a different pathogenetic mechanism for each of these subpopulations of rheumatoid arthritis.
HEART VESSEL COUPLING IN SUBJECT WITH RISK FACTORS: A LONGITUDINAL LEFT VENTRICULAR FUNCTION AND ARTERIAL STIFFNESS STUDY
Authors: Concetta Zito, Maurizio Cusmà Piccione, Gianluca Di Bella, Raffaella Iudicello, Caterina Longordo, Carmelo Nipote, Maria Rosaria Giuffrè, Roberta Nava, Girolamo Gioffrè, Scipione Carerj
Journal: Journal of the American College of Cardiology (2010)
Preventing Sexually Transmitted Infections Among Adolescents
Authors: Ralph J. DiClemente
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oversupply of Medical Graduates.
Authors: A. W. Clouse
Journal: JAMA (1901)

Geneva, Pa., Aug. 12, 1901. <h3>To the Editor:</h3> —Much has been written lately concerning the oversupply of physicians in the United States. Permit me to say a word on the negative side of the question. All the writers noted so far taking as a basis the recent census—which shows a ratio of 1 physician to 600 population— reason a<i>priori</i>that this is largely in excess of the demand. The facts, I believe, do not support this conclusion, particularly in the rural districts throughout the north and west, with which I am familiar. In villages and towns varying in population from 500 to 2000, nine out of ten physicians will claim to be making from $2000 to $3000 per annum. More will be found who claim to be making in excess of $3000 than those who will admit that they are making less than $2000. These statements are corroborated by
<i>Helicobacter pylori</i>Infection
Authors: Kenneth E.L. McColl
Journal: New England Journal of Medicine (2010)

A 29-year-old man presents with intermittent epigastric discomfort, without weight loss or evidence of gastrointestinal bleeding. He reports no use of aspirin or nonsteroidal antiinflammatory drugs. A serologic test for Helicobacter pylori is positive, and he receives a 10-day course of omeprazole, amoxicillin, and clarithromycin. Six weeks later, he returns with the same symptoms. How should his case be further evaluated and managed?
Increase in antibiotic resistance in Haemophilus influenzae in the United Kingdom since 1977.
Authors: R J Fallon
Journal: BMJ (1982)

treatment it could mean that the patient was receiving months of unnecessary, ineffective, and expensive treatment.Ultrasound is likely to prove useful in detecting spontaneous gall-stone recurrence and in monitor- ing the efficacy of postdissolution treatments given in attempts to prevent recurrence.If recurrent stones are detected, however, and treatment options include the possibility of further dissolution therapy, supplementary oral cholecystography will again be necessary.In our present state of ignorance, we agree that it seems sensible to use both cholecysto- graphy and ultrasonography of the gall bladder in monitoring the response to medical treatment and in the follow-up of patients after "confirmed" complete gall-stone dissolution.Indeed, this has been our policy since reliable ultrasonography first became available at Guy's Hospital.The routine use of both techniques is also part of the protocol of the British National Gall-stone Group in their multicentre, postdissolution trial.But to return to Dr Somerville and colleagues' title question: are we being misled?We do not think so, but we do not know and until the incidence of false-positive and false-negative results with both imaging techniques be- comes established, we believe that we should keep an open mind and avoid dogma.
The Relationship between Neuroticism and Blood Pressure Reexamined
Authors: Th. Köhler, N. Scherbaum, R. Richter, S. Böttcher
Journal: Psychotherapy and Psychosomatics (1993)

Given the contradictory results reported in the literature on the relationship between neuroticism and blood pressure, it was decided to reexamine this topic. This was done with a large sample very homogeneous for age, sex, food intake and life style and basically unselected in terms of medical history. In the frame of a blood donation program blood pressure was measured in 810 conscripts. In addition, subjects completed either form A or form B of the Eysenck Personality Inventory (EPI). Data from a total of 624 subjects were suitable for evaluation. No significant correlations were obtained between systolic or diastolic blood pressure and scores of neuroticism or extraversion (r = -0.10 to 0.06) nor did groups with different blood pressure values differ substantially in terms of these variables. This supports work showing that there is no essential connection between blood pressure and emotional lability as measured by the EPI.
Chest X-ray Film in Acute Myocardial Infarction
Authors: A. E. Tattersfield, M. W. McNicol, H. Shawdon, D. Rolfe
Journal: BMJ (1969)

A total of 185 chest x-ray films taken on 50 consecutive admissions to a coronary care unit were assessed independently for specific abnormalities by three observers. The commonest abnormality was upper lobe pulmonary venous congestion. When this was present by itself it did not appear to affect prognosis. Pulmonary oedema occurred in 12 of the patients, was associated with more pronounced pulmonary venous congestion (but not necessarily with cardiac enlargement), and usually cleared within five days. Generalized cardiac enlargement and septal lines were rarely seen. Clinically silent non-segmental shadows were found in six patients.No consistent change in radiological abnormality was found in the first three days after infarction, but thereafter a gradual improvement occurred, so that before discharge the x-ray picture was nearly normal. There was good correlation between the presence and extent of lung crepitations and the presence of pulmonary oedema on the chest x-ray film.It is suggested that the chest x-ray film is a useful additional index of the severity of heart failure in myocardial infarction.