tbuckley/cabot-search huggingface dataset:
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
Authors: Frank Tacke, David Alvarez, Theodore J. Kaplan, Claudia Jakubzick, Rainer Spanbroek, Jaime Llodra, Alexandre Garin, Jianhua Liu, Matthias Mack, Nico van Rooijen, Sergio A. Lira, Andreas J. Habenicht, Gwendalyn J. Randolph
Journal: Journal of Clinical Investigation (2007)

Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR2+CX3CR1+Ly-6Chi and CCR2–CX3CR1++Ly-6Clo monocytes. Both C-C motif chemokine receptor 2 (CCR2) and C-X3-C motif chemokine receptor 1 (CX3CR1) are linked to progression of atherosclerotic plaques. Here, we analyzed mouse monocyte subsets in apoE-deficient mice and traced their differentiation and chemokine receptor usage as they accumulated within atherosclerotic plaques. Blood monocyte counts were elevated in apoE–/– mice and skewed toward an increased frequency of CCR2+Ly-6Chi monocytes in apoE–/– mice fed a high-fat diet. CCR2+Ly-6Chi monocytes efficiently accumulated in plaques, whereas CCR2–Ly-6Clo monocytes entered less frequently but were more prone to developing into plaque cells expressing the dendritic cell–associated marker CD11c, indicating that phagocyte heterogeneity in plaques is linked to distinct types of entering monocytes. CCR2– monocytes did not rely on CX3CR1 to enter plaques. Instead, they were partially dependent upon CCR5, which they selectively upregulated in apoE–/– mice. By comparison, CCR2+Ly-6Chi monocytes unexpectedly required CX3CR1 in addition to CCR2 and CCR5 to accumulate within plaques. In many other inflammatory settings, these monocytes utilize CCR2, but not CX3CR1, for trafficking. Thus, antagonizing CX3CR1 may be effective therapeutically in ameliorating CCR2+ monocyte recruitment to plaques without impairing their CCR2-dependent responses to inflammation overall.
Irinotecan-Cisplatin Therapy for Patients with Extensive-Stage Small Cell Lung Cancer: Use Patterns among American Medical Oncologists 2000–2006
Authors: Mark R. Green, Afshin Dowlati, Lalitha Yellamraju, Laura Daniels, Joanne Willey, Michele Andrews, Richard Leff
Journal: Journal of Thoracic Oncology (2007)
Psychiatric Symptoms in Adolescents
Authors: Peter G. S. Beckett
Journal: JAMA (1966)

Large numbers of adolescents are currently being referred to physicians, especially psychiatrists, for disturbed behavior. Which of these cases really belong within the field of medicine? Attempts to answer this have included efforts to demonstrate specific syndromes, to demonstrate nonutopian behavior or conflicts, and to evaluate motivation for change. Another approach is to define disturbed behavior as "nonaverage," implying that the patient's behavior should be compared to the average in his social environment. None of these are completely satisfactory, but it is clear that the social environment is of great importance to adolescents. Since this is so, treatment should harness group forces as well as individual ones. These include the following: emphasis on a responsive group environment to facilitate the learning of socially appropriate behavior; controlled emotional arousal to promote identification with appropriate adults; and encouragement of peer-group forces which emphasize leadership, responsibility, and foresight.
DERMATOMYOSITIS AND CARCINOMA (A STUDY BASED ON AN 18 YEAR FOLLOW-UP IN BULGARIA)
Authors: B. BATSCHWAROV, D. MINKOV
Journal: British Journal of Dermatology (1968)

Journal Article DERMATOMYOSITIS AND CARCINOMA (A STUDY BASED ON AN 18 YEAR FOLLOW‐UP IN BULGARIA) Get access B. BATSCHWAROV, B. BATSCHWAROV Higher Medical Institute “I. P. Pavlov”, (Dr. Batschwarov) and Clinic of Skin and Venereal Diseases, Plovdiv, Bulgaria (Dr. Minkov) Search for other works by this author on: Oxford Academic Google Scholar D. MINKOV D. MINKOV Higher Medical Institute “I. P. Pavlov”, (Dr. Batschwarov) and Clinic of Skin and Venereal Diseases, Plovdiv, Bulgaria (Dr. Minkov) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 2, 1 February 1968, Pages 84–85, https://doi.org/10.1111/j.1365-2133.1968.tb12265.x Published: 01 February 1968 Article history Accepted: 21 July 1967 Published: 01 February 1968
Case 50-1966
Authors: Rita M. Kelley, Benjamin Castleman
Journal: New England Journal of Medicine (1966)

Presentation of CaseA seventeen-year-old woman was admitted to the hospital because of hemiparesis.She had been well until twelve days previously, in the thirtieth week of an uneventful first pregnancy, when severe weakness developed, followed by unresponsiveness. She was taken to another hospital, where examination disclosed hyperactive and symmetrical tendon reflexes and bilateral ankle clonus. The hemoglobin was 4.4 gm. per 100 ml.; marked anisocytosis, poikilocytosis, polychromatophilia and macrocytosis were found on the blood smear. Urinalysis disclosed numerous white cells. A lumbar puncture was reported to be negative. Four units of whole blood were transfused, with a return of . . .
PMO-182 HCV research UK: a UK national resource to support research into HCV infection
Authors: W Irving, J McLauchlan, G Foster, J Dillon, S Hutchinson, B Wilkes
Journal: Gut (2012)

<h3>Introduction</h3> Background: Hepatitis C virus (HCV) infection has been identified by the MRC and Department of Health MRC as a priority area for research and development to meet the clinical challenges posed by the scale of the infection in the UK. There has been a perceived lack of connection between clinicians and basic scientists working on HCV in the UK to address this problem. Aims: To create a multi-disciplinary consortium comprising clinicians and non-clinical scientists to encourage translational research. To establish a cohort of 10 000 patients with HCV infection across the UK, together with clinical database and biorepository—“HCV Research UK”. To make this resource available to researchers, both academic/commercial, UK-based and abroad. <h3>Methods</h3> Aims: Our objective has been to create a multi-disciplinary consortium comprising clinicians and non-clinical scientists to encourage translational research into the factors that determine outcome of infection, treatment response and disease progression. We aim to establish a cohort of 10 000 patients with HCV infection from across the UK that is supported by the necessary systems to make clinical data and specimens available to academic and commercial researchers, both in the UK and abroad. <h3>Results</h3> Progress: HCV Research UK has been funded by the Medical Research Foundation (£1.92 million) to establish an infrastructure that connects 18 clinical centres who will recruit 10 000 HCV-infected patients. The key elements of the infrastructure are a bespoke clinical research database, which is linked to a biorepository of samples that will hold serum, PBMCs and DNA from patients. Access to data and samples is managed by a Tissue and Data Access Committee who have the authority to grant ethical approval for research using the resource. The study has been given CLRN portfolio status. <h3>Conclusion</h3> Future plans: Recruitment of patients will begin in early 2012 and grant applications have been submitted to (1) Wellcome/Department of Health Innovation Challenge fund (2) MRC call for Stratified Medicine (3) BLT Research call (4) NIHR Programme Development award schemes for research using the resource. It is hoped that portfolio support will provide a mechanism for new centres to join the consortium. <h3>Competing interests</h3> None declared.
Intra-arterial Chemotherapy for Recurrent Neoplasms
Authors: Seymour Tindel
Journal: JAMA (1967)

Twenty-eight intra-arterial infusions were carried out in 25 symptomatic patients all of whom had recurrent but still regionally confined disease. Most patients had had previous surgery and/or radiation. Four of these patients died as a direct result of the treatment and ten others had complications. Four patients are still alive but have recurrences. The average survival time of the dead patients was 4 1/2 months after treatment. Although this type of treatment was occasionally helpful, few of our patients actually benefited significantly from it. Furthermore, the substantial complication rate and mortality limits its use as a palliative measure.
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy
Authors: P. Solís-Muñoz, J. Solís-Herruzo, G. López-Alonso, F. Colina-Ruizdelgado, T. Muñoz-Yague
Journal: Endoscopy (2010)

In the September issue of Endoscopy, Kim et al. [1] described a group of 20 patients (out of 633 endoscopic mucosal resections [EMR] or endoscopic submucosal dissections [ESD]; 3.2 %) with negative histologic findings, despite the fact that the previous forceps biopsy displayed a high-grade dysplasia or intramucosal carcinoma. The authors suggest that the tumor might have been so small that it was probably removed with the forceps biopsy before the EMR or ESD. As another option for this lack of tumor in the resection tissue is sampling error, the authors recommend good communication between endoscopist and pathologist. A recent study by Rabenstein et al. described 22 patients with invisible gastric cancer (IGC) in whom gastrectomy would normally be recommended. The authors suggest that gastrectomy may not be the only option for IGC, which might follow an uneventful natural course, provided careful follow-up is scheduled. They also used photodynamic therapy in the area where the biopsy was taken; however further studies are needed in relation to this type of treatment [2].
Switch to diesel engines is significantly to blame for poor air quality in UK cities, experts say
Authors: I. Torjesen
Journal: BMJ (2014)

<h3>Introduction</h3> The onset of the Covid19 pandemic in early 2020 resulted in a severe restriction of endoscopy capacity such that, for some months, only emergency cases were able to undergo procedures. In order to mitigate clinical in those patients who had their procedures cancelled, enhanced vetting &amp; remote clinic review was undertaken as per BSG guidance, with interim CT abdomen/pelvis scans arranged for those patients still deemed to require urgent investigation. The aim of this study is to look at the outcomes for this group of patients with cancelled colonoscopies due to the COVID-19 pandemic. <h3>Method</h3> All patients who had their colonoscopy appointment cancelled, or new referrals that were unbooked, at 30/3/20 were identified from the waiting list. Data for the outcomes of enhanced vetting, CT scan results and colonoscopies, was collected from the electronic patient. <h3>Results</h3> 138 patients were identified (62.3% female, 37.7% male, median age 60 years, age range 23-85 years old). The outcomes after enhanced vetting were: 1 (0.7%) patient with a previously abnormal CT scan showing possible tumour proceeded directly to surgery, 74 (53.6%) patients were categorised as deferred urgent colonoscopy required, 45 (32.6%) patients as deferred non-urgent colonoscopy required, 7 (5.1%) patients no longer required colonoscopy, and 11 (8.0%) defaulted/refused clinic appointment/colonoscopy. of the 74 patients requiring deferred urgent colonoscopy, 10 had their colonoscopy requested following a previously abnormal CT scan. Interim imaging with CT scan was performed for the remaining 64 patients; a mass lesion was demonstrated in 2 (3.1%) cases, with subsequent diagnosis of cancer in one and high-grade dysplasia in the other. of the 62 patients without a mass lesion on CT scan, no cancer was detected in 52 patients that underwent deferred colonoscopy; 10 patients either refused/defaulted colonoscopy or a clinical decision was made not to proceed to colonoscopy following the CT. of the 10 patients with prior CT scan proceeding to urgent deferred colonoscopy, one high grade dysplasia polyp was detected. Non-urgent deferred colonoscopy was undertaken in 45 patients of which non had any high-grade lesions or malignancy detected. <h3>Conclusion</h3> Enhanced vetting together with use of interim CT scanning was effective at minimising clinical risk in patients unable to undergo colonoscopy due to restricted capacity during the COVID19 pandemic.
Rapidly Enlarging “Bruise” on the Back of an Infant
Authors: Stephanie Chan, David S. Cassarino
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Diagnosis and Treatment of Primary Aldosteronism
Authors: Jon D. Blumenfeld
Journal: Annals of Internal Medicine (1995)

Letters15 May 1995Diagnosis and Treatment of Primary AldosteronismJon D. Blumenfeld, E. Darracott Vaughan Jr., and John H. LaraghJon D. BlumenfeldUniversity of Alberta Hospital, Edmonton, Alberta T6G 2B7, Canada. The New York Hospital-Cornell Medical Center, New York, NY 10021.Search for more papers by this author, E. Darracott Vaughan Jr.University of Alberta Hospital, Edmonton, Alberta T6G 2B7, Canada. The New York Hospital-Cornell Medical Center, New York, NY 10021.Search for more papers by this author, and John H. LaraghUniversity of Alberta Hospital, Edmonton, Alberta T6G 2B7, Canada. The New York Hospital-Cornell Medical Center, New York, NY 10021.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-10-199505150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:McAlister and Lewanczuk reemphasize several important issues about the selection of patients for unilateral adrenalectomy. First, it is well established that small (<5.0 cm), nonfunctioning adrenal tumors, which are usually identified incidentally during radiographic evaluation, do not require resection.Second, patients with biochemical evidence of hyperaldosteronism usually have radiographic abnormalities of one or both adrenal glands. When the aldosterone-producing adrenal lesion is hyperplastic or has a heterogeneous radiographic appearance, extensive biochemical characterization is essential to determine whether the related metabolic abnormalities and hypertension are surgically curable. This evaluation includes assessments of the autonomy of aldosterone secretion (failure to ...References1. Blumenfeld JD, Sealey JE, Schlussel Y, Vaughan ED Jr, Sos TA, Atlas S, et al. Diagnosis and treatment of primary hyperaldosteronism. Ann Intern Med. 1994; 121:877-85. Google Scholar2. Fontes R, Kater C, Biglieri EG, Irony II. Reassessment of the predictive value of the postural stimulation test in primary aldosteronism. Am J Hypertens. 1991; 4:786-91. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Alberta Hospital, Edmonton, Alberta T6G 2B7, Canada. The New York Hospital-Cornell Medical Center, New York, NY 10021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1995Volume 122, Issue 10Page: 800-801KeywordsAdrenalectomyAldosteroneBlood plasmaDecision makingHypertensionLesionsPostural controlSurgical outcomesTumor resectionVeins ePublished: 15 August 2000 Issue Published: 15 May 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Phase-related sensitivity of the sinoatrial node to vagal stimuli in the isolated rat atrium.
Authors: S L Stuesse, M N Levy, H Zieske
Journal: Circulation Research (1978)

In isolated rat atria, endogenous neurotransmitters were released by electrical pulses that were below threshold for activation of the myocardial cells.A brief train of pulses was delivered at a specified time after each atrial activation to determine the relationship between the time of stimulus delivery during an atrial cycle (P-St interval) and the subsequent cardiac cycle length (P-P interval).These stimuli caused a change in P-P interval from a mean control level of 291 msec to a mean maximum P-P interval of 592 msec.This change was attributed to the release of neurotransmitters from sympathetic and parasympathetic fibers, but the effects from the parasympathetic nerve terminals predominated.Increasing the number of pulses per burst increased the atrial slowing.The extent of slowing was dependent on the time of stimulus delivery in an atrial cycle.The region of minimal effectiveness (mean P-P interval of 412 msec during stimulation) was obtained with P-St intervals that were only slightly greater (about 10 msec) than those that were maximally effective.Stimuli delivered at times in the cardiac cycle that fell between the P-St intervals that elicited maximum and minimum changes in heart rate occasionally caused profound irregularities in heart rate.These changes in cycle length do not appear to be due to pacemaker shifts, but are probably the result of the interaction between acetylcholine and the sinoatrial nodal cell membrane.The responsiveness of this membrane to acetylcholine changes with time during the cardiac cycle.
CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules
Authors: LE Van den Hove, SW Van Gool, P Vandenberghe, M Bakkus, K Thielemans, MA Boogaerts, JL Ceuppens
Journal: Leukemia (1997)
Controlled trial of an audit facilitator in diagnosis and treatment of childhood asthma in general practice
Authors: F. P Bryce, R. G Neville, I. K Crombie, R. A Clark, P. McKenzie
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective</b>: To test whether an audit facilitator could alter the pattern of diagnosis and treatment of childhood asthma. <b>Design</b>: Randomised stratified controlled trial. <b>Setting</b>: 12 general practices in Tayside. <b>Subjects</b>: 3373 children aged 1-15 inclusive who had symptoms suggestive of asthma or possible asthma drawn from a systematic review of 10 725 general practice case records. <b>Intervention</b>: Children were targeted for a clinical review by their general practitioner or practice nurses. <b>Main outcome measures</b>: Asthma related consultations, precriptions, hospital attendances, and health service costs 12 months before and after study. <b>Results</b>: Compared with controls (n=1563) the intervention group (n=1585) had more practice initiated consultations for asthma (relative risk 2.18 (95% confidence interval 1.74 to 2.73)), new diagnoses of asthma (2.83 (2.26 to 3.54)), and past diagnoses reaffirmed (1.30 (1.08 to 1.58)), and they were more frequently prescribed inhaled cromoglycate (1.52 (1.02 to 2.25)). Hospital inpatient day rates fell from 152 to 122 in the intervention group and rose from 69 to 117 in the control group between the year before and the year after study. Total primary care costs rose from pounds sterling30118 to pounds sterling37243 in the intervention group and fell from pounds sterling29131 to pounds sterling27990 in the control group. Hospital care cost fell in the intervention group from pounds sterling25406 to pounds sterling20727 and rose in the control group from pounds sterling12699 to pounds sterling19650. <b>Conclusion</b>: An audit facilitator can favourably influence the pattern of diagnosis and treatment of childhood asthma in general practice. This may have an impact on health service costs. <h3>Key messages</h3> Key messages Controlled trial of an audit facilitator is feasible in primary care Intervention of an audit facilitator resulted in desirable changes in the diagnosis and treatment of asthma in children in general practice Such intervention may also have had an impact on the use of hospital resources and on health care expenditure
THE ASSOCIATION OF LEFT VENTRICULAR HYPERTROPHY WITH INTRAVENTRICULAR DYSSYNCHRONY AT REST AND DURING EXERCISE IN HYPERTENSIVE PATIENTS
Authors: Hye–Sun Seo, Youn–Haeng Cho, Jae Huk Choi, Jon Suh, Nae–Hee Lee
Journal: Journal of the American College of Cardiology (2013)
Risky business: doctors' understanding of statistics
Authors: C. Martyn
Journal: BMJ (2014)

As medicine becomes increasingly preventive, doctors need a good grasp of risk



Nearly 40 years ago the New England Journal of Medicine published a short survey of doctors’ understanding of the results of diagnostic tests.1 The participants, all doctors or medical students at Harvard teaching hospitals, were asked, “If a test to detect a disease whose prevalence is 1/1000 has a false positive rate of 5%, what is the chance that a person found to have a positive result actually has the disease, assuming that you know nothing else about the person’s symptoms or signs?” This wasn’t a very difficult question, which made the results all the more shocking. Fewer than a fifth of participants gave the correct answer, and most thought that the hypothetical patient had a 95% chance of having the disease.

Of course, this was a long time ago, and medical curriculums now contain much more in the way of statistics and probabilistic reasoning. You might expect that if the exercise were repeated today almost everyone would give the right answer. But you’d …
Estrogens and Endometrial Cancer-Reply
Authors: Carol M. Proudfit
Journal: JAMA (1977)

<h3>In Reply.—</h3> Dr Austin's data were correctly quoted in the article. The apparent discrepancy between Austin's data and those quoted by Christopherson can largely be accounted for by the fact that the Austin data were not age-adjusted rates, but rather age-specific incidence rates, a point that should have been specified in my article for clarification. Use of ageadjusted rates for examining trends in incidence of endometrial cancer obscures the effect of age, and is therefore inappropriate when considering this generally age-specific (postmenopausal), age-related disease.
OCCUPATIONAL DERMATITIS FROM WOOD TURPENTINE
Authors: Carey P. McCord
Journal: JAMA (1926)

The best grade of turpentine is obtained by tapping the living pine trees collecting the resins that exude, and refining them. The turpentine so derived is "gum spirits of turpentine." This method is wasteful of timber, and its use is rapidly diminishing. Lumbering operations afford every year a vast lot of waste wood. Attempts are being made to produce a high grade of turpentine from these rejected woods and uprooted ancient stumps through steam distillation and destructive distillation methods. The Naval Stores Act of 1924, recognizes these grades of turpentine: "Gum spirits of turpentine," which means spirits of turpentine made from gum (oleoresin) from a living tree. "Steam distilled wood turpentine," which is wood turpentine distilled with steam from the oleoresin within or extracted from the wood. "Destructively distilled wood turpentine," wood turpentine obtained in the destructive distillation of the wood. "Wood turpentine," which includes steam distilled wood turpentine and