Normal Fetus After Cytosine Arabinoside Therapy
Authors: DAVID F. PAWLIGER
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 June 1971Normal Fetus After Cytosine Arabinoside TherapyDAVID F. PAWLIGER, M.D., FREDERICK W. MCLEAN, M.D., WARD D. NOYES, M.D.DAVID F. PAWLIGER, M.D.Search for more papers by this author, FREDERICK W. MCLEAN, M.D.Search for more papers by this author, WARD D. NOYES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-6-1012_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Cytosine arabinoside (ARA-C) induces remissions in a significant number of patients with acute granulocytic leukemia (1-3). Although there are observations on the effects of ARA-C in pregnant laboratory animals and their fetuses (4), there are no reports of its use in human pregnancy.A 23-year-old white woman was hospitalized in October 1969 with high WBC count, anemia, fever, splenomegaly, and cutaneous infections. Her last menstrual period began 29 April 1969, and she had a positive pregnancy test in June. The uterus was enlarged to the umbilicus, and fetal heart sounds were present. Laboratory results included hematocrit 28;...References1. LIVINGSTONCARTER RS: Cytosine arabinoside (NSC-63878)—clinical brochure. Cancer Chemother Rep 1 (suppl) : 179-205, 1968 Google Scholar2. BODEYFREIREICHMONTO GER: Cytosine arabinoside therapy for acute leukemia in adults. Cancer Chemother Rep 53:59-66, 1969 MedlineGoogle Scholar3. GEEYUCLARKSON TKB: Treatment of adult acute leukemia with arabinosylcytosine and thioguanine. Cancer 23: 1019-1032, 1969 CrossrefMedlineGoogle Scholar4. CHAUBEMURPHY SM: The teratogenic effects of cytosine arabinoside on the rat fetus. Amer Assoc Cancer Res 6:11, 1965 Google Scholar5. BREWEN J: The induction of chromatid lesions by cytosine arabinoside in post-DNA-synthetic human leukocytes. Cytogenetics (Basel) 4:28-36, 1965 CrossrefMedlineGoogle Scholar6. FISCHERJONAS DA: Cerebellar hypoplasia resulting from cytosine arabinoside treatment in the neonatal hamster. Clin Res 13:540, 1965 Google Scholar7. NICHOLSON H: Cytotoxic drugs in pregnancy: review of reported cases. J Obstet Gynaec Brit Comm 75:307-312, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Hematology Department of Medicine University of Florida Gainesville, Fla. 32601 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCancer chemotherapeutic agents as human teratogensAcute leukemia in pregnancy: Report of five cases treated with a combination which included a low dose of adriamycinCancer in pregnancySuccessful pregnancy during chemotherapy for acute leukemiaAcute Non-lymphocytic Leukaemia in the Third Trimester of PregnancyNormal Infant after Treatment of Acute Myeloid Leukaemia in Pregnancy with DaunorubicinNormales Neugeborenes nach zytostatischer Therapie bei akuter Promyelozytenleuk�mie in der SchwangerschaftTherapeutic leukopheresis of acute myelo-monocytic leukemia in pregnancyConsequences of acute myelogenous leukemia in early pregnancyPREGNANCY AND LEUKÆMIATHE DOCTOR'S ROLE IN FERTILITY REGULATIONGranulocytic sarcoma.Local presentation of a systemic diseaseTreatment of acute leukemia during pregnancy 1 June 1971Volume 74, Issue 6Page: 1012-1012KeywordsCytosineFetusesFeversHeartHematocritPregnancyResearch laboratoriesSplenomegalyUterusWhite blood cells Issue Published: 1 June 1971 PDF downloadLoading ...