tbuckley/cabot-search huggingface dataset:
Cyclosporin for treatment of life‐threatening alloimmunization
Authors: Hervé Tilly, Michael Azagury, Dominique Bastit, Anne Lallemand, Hubert Piguet
Journal: American Journal of Hematology (1990)

Abstract We describe a 16‐year‐old girl with aplastic anemia who, 1 year after initial diagnosis, developed a refractory state to platelet transfusions due to alloimmunication and resulting in severe bleeding. Treatment with cyclosporin, initially prescribed as treatment of the bone marrow failure, resulted in prompt decrease in lymphocytotoxic antibodies, which paralleled a marked improvement in platelet recovery. To our knowledge, such a dramatic effect of cyclosporin on alloimmunization has not been previously reported and merits further attention.
INTRACARDIC INJECTION OF DEXTROSE IN A CASE OF INSULIN HYPOGLYCEMIA
Authors: Stanley W. Imerman
Journal: JAMA (1927)

Mrs. R. K., aged 54, was admitted into the ward service of Dr. Ralph Bettman, Michael Reese Hospital, Chicago, Aug. 10, 1927, with the complaint of gangrene of the first toe of the right foot of six months' duration. She had been treated for diabetes mellitus, and in spite of the fact that the urine was sugar free without the use of insulin, the gangrene had progressed. On admission a mild generalized arteriosclerosis was found. The great toe was in a condition of dry gangrene to the proximal end of the first metatarsai joint. There was no evidence of toxic absorption. On admission the leukocyte count was 12,500; the blood sugar was 220 mg.; the urine was sugar free. The blood pressure was 164 systolic and 70 diastolic. Amputation of the right toe was done, August 15. Following this the blood sugar was 276 mg. The urine contained acetone,
Abstract 3799: Polyamine Transport System (PTS) activity and hijacking in cancer cells: New option in Head and Neck tumors treatment with the polyamine-containing drug candidate F14512
Authors: Samuel Meignan, Francois Mouawad, Amelie Dewitte, Charlotte Bertheau, Nicole Wattez, Abigaelle Gros, Eric Lartigau, Dominique Chevalier, Christian Bailly, Amelie Lansiaux
Journal: Cancer Research (2012)

Abstract The Polyamine Transport System, although not clearly identified at the molecular level in eukaryotic organisms, was found over activated in many types of cancer cells, such as leukemia, prostate, melanoma and NSCLC. Polyamines are implicated in many biological functions, and the need for polyamines in tumor cells, conveyed by the PTS, is crucial. New therapeutic strategies consist to use this transport system to deliver a cytotoxic agent specifically into cancer cells. Head and neck cancer remains the 6th common cancer with a very poor survival rate indicating the crucial need for new targeted strategies. For this study, we used 4 Head and Neck (H &amp; N) cancer cell lines representative of various localizations: CAL 33 and CAL 27 from base of the tongue, Fadu from the pharynx and SQ20B from the larynx. Here, using a polyamine-coupled fluorescent probe, we show that the PTS is active in all head and neck cancer cell lines regardless the tumor localization. In these models, flow cytometry demonstrated that the PTS incorporates quickly, massively and specifically the probe into cancer cells. Confocal microscopy observations revealed that the spermine probe accumulates into the cell nuclei, the site of action of F14512 which is a potent topoisomerase II inhibitor. Considering this property, we evaluated the potential of the F14512 (Pierre Fabre laboratories, France) in these H &amp; N cancer cell lines. F14512 contains a PTS-recognized spermine side chain attached to an epipodophyllotoxin moiety targeting topoisomerase II. We found that F14512 presents a much higher cytotoxicity than etoposide in the 4 cell lines. Competition assays showed that this effect is dependent of the PTS activity and confirmed the targeted action of F14512 against cells with active PTS. The high efficiency of F14512 in the head and neck cancer cell lines is reported here for the first time and may be of interest for the future development of this novel drug candidate, currently in phase 1 clinical trial in leukemia. Studies are in progress, using fresh tumor biopsies from patients with head and neck cancer, to analyze the PTS status of the tumors using the specific spermine-containing fluorescent probe and to evaluate the activity of F14512. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3799. doi:1538-7445.AM2012-3799
Smoking ban improves health of bartenders
Authors: S. Gottlieb
Journal: BMJ (1999)

San Francisco bartenders had dramatic improvements in respiratory health within two months, after the implementation of California's ban on indoor smoking sharply reduced their exposure to secondhand smoke.

In a study examining 53 bartenders before and after the ban was implemented, Dr Mark Eisner and colleagues at the University of California at San Francisco found that 59% (23) of those bartenders reporting respiratory …
Why Physicians Ought to Lie for Their Patients
Authors: Nicolas Tavaglione, Samia A. Hurst
Journal: The American Journal of Bioethics (2012)

Abstract Sometimes physicians lie to third-party payers in order to grant their patients treatment they would otherwise not receive. This strategy, commonly known as gaming the system, is generally condemned for three reasons. First, it may hurt the patient for the sake of whom gaming was intended. Second, it may hurt other patients. Third, it offends contractual and distributive justice. Hence, gaming is considered to be immoral behavior. This article is an attempt to show that, on the contrary, gaming may sometimes be a physician's duty. Under specific circumstances, gaming may be necessary from the viewpoint of the internal morality of medicine. Moreover, the objections against gaming are examples of what we call the idealistic fallacy, that is, the fallacy of passing judgments in a nonideal world according to ideal standards. Hence, the objections are inconclusive. Gaming is sometimes justified, and may even be required in the name of beneficence. Keywords: organizational ethicsphilosophyprofessional ethicsprofessional–patient relationshiprationing/resource allocationright to health care
Quebec will make doctors disclose their HIV status
Authors: David Spurgeon
Journal: BMJ (2004)

Quebec's health minister and the province's College of Physicians are preparing a mandatory disclosure policy for doctors who are HIV positive, after Montreal's Hopital Ste Justine had to offer HIV testing to 2614 patients who had been operated on by a paediatric surgeon with HIV infection.

Under the new policy, doctors infected by HIV or other contagious pathogens will have to disclose their condition to hospital or college authorities, but the health minister, Philippe …
Abstract 13357: Diffuse Intimal Thickness without Lipid or Calcium Content at Branch Points is a Characteristic Feature of Coronary Artery in Patitents with Coronary Spastic Angina : Optical Coherence Tomography Analysis
Authors: Hitoshi Nakagawa, Shiro Uemura, Manabu Horii, Kenichi Ishigami, Tsuneari Soeda, Sung Ji Hee, Satoshi Somekawa, Satoshi Okayama, Yoshinobu Morikawa, Yuji Mizuno, Eisaku Harada, Hirofumi Yasue, Yoshihiko Saito
Journal: Circulation (2010)

Background: Endothelial nitric oxide (NO) activity is deficient at the arterial wall where shear stress is low or oscillatory. Decreased NO activity plays an important role in the development of in...
Liver transplantation for Wilson's disease: Indications and outcome
Authors: Michael L. Schilsky, Herbert I. Scheinberg, Irmin Sternlieb
Journal: Hepatology (1994)

The objective of this study was to determine the indications for and results of liver transplantation in patients with Wilson’s disease on the basis of results of a survey with retrospective review of data obtained on 55 transplants performed at centers in the United States and Europe. The study group comprised 32 females and 23 males, aged 8.5 to 51 yr, with features diagnostic of Wilson’s disease. Indication for orthotopic liver transplantation included hepatic insufficiency (n = 32), wilsonian fulminant hepatitis (n = 21), intractable neurological Wilson’s disease (n = 1) and gastrointestinal hemorrhage (n = 1). Forty-three patients have survived, at this writing, from 3 mo to 20 yr. Mean and median survival after orthotopic liver transplantation were 2.7 and 2.5 yr, respectively. Survival at 1 yr was 79. Nonfatal complications occurred in five patients. Of the seven patients given transplants for hepatic insufficiency who manifested neurological and/or psychiatric manifestations at the time of orthotopic liver transplantation, four showed improvement of these symptoms. One patient given a transplant for intractable neurological disease improved but died of a vascular complication. Our data demonstrate that liver transplantation is life-saving but not without risk for patients with wilsonian fulminant hepatitis or chronic severe hepatic insufficiency unresponsive to medical therapy. Furthermore, neurological or psychiatric symptoms due to Wilson’s disease may improve after liver transplantation; however, the role of this procedure in the management of patients with neurological Wilson’s disease in the absence of hepatic insufficiency is still uncertain. (Hepatology 1994;19:583-587).
Hypercalcemia and Tamoxifen Readministered
Authors: Raymond Taetle, John Mendelsohn, Mark R. Green
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 August 1978Hypercalcemia and Tamoxifen ReadministeredRAYMOND TAETLE, M.D., JOHN MENDELSOHN, M.D., MARK R. GREEN, M.D.RAYMOND TAETLE, M.D.Search for more papers by this author, JOHN MENDELSOHN, M.D.Search for more papers by this author, MARK R. GREEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-2-287_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Kiang and Kennedy (1) of tamoxifen therapy in advanced breast cancer noted only two patients with hypercalcemia. Both patients had negative assays for estrogen receptors and were bedridden at the time this complication occurred. Other studies have reported hypercalcemia in estrogen-receptor-positive patients (2). We wish to report our experience with readministration of this agent to a patient who previously had become hypercalcemic on tamoxifen therapy.A 57-year-old woman underwent a right radical mastectomy followed by local radiation therapy in 1971. Cancer in the left breast was treated by radical mastectomy in 1973. In June...References1. KIANGKENNEDY DB: Tamoxifen (antiestrogen) therapy in advanced breast cancer. Ann Intern Med 87:687-690, 1977 LinkGoogle Scholar2. VELDHUIS J: Tamoxifen and hypercalcemia (letter). Ann Intern Med 88:574-575, 1978 LinkGoogle Scholar3. MORGANSCHEINWOOLLEYHOTHMACDONALDLIPPMANPOSEYBEAZLEY LPPDJMLR: Therapeutic use of tamoxifen in advanced breast cancer: correlation with biochemical parameters. Cancer Treat Rep 60:1437-1443, 1976 MedlineGoogle Scholar4. Product Monograph. Wilmington, Delaware, Stuart Pharmaceuticals, 1977, p. 13 Google Scholar5. HENNINGERAMBERGER BH: Anti-ostrogene Therapie des metastasierenden Mammakarzinoms. Dstch Med Wochenschr 102:713-716, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of California at San Diego San Diego, CA 92103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTamoxifen-induced hypercalcemia in breast cancer 1 August 1978Volume 89, Issue 2Page: 287-287KeywordsBreast cancerEstrogensHypercalcemiaRadiation therapy Issue Published: 1 August 1978 PDF DownloadLoading ...
THE TREATMENT OF FAVUS WITH GRISEOFULVIN.
Authors: H. KOPP, S. A. KVORNING, P. V. MARCUSSEN
Journal: British Journal of Dermatology (1960)

Journal Article THE TREATMENT OF FAVUS WITH GRISEOFULVIN. Get access H. KOPP, H. KOPP Dept. of Dermatology, The Finsen Institute, Copenhagen. (Chief: Poul V. Marcussen, M.D.) Search for other works by this author on: Oxford Academic Google Scholar S. A. KVORNING, S. A. KVORNING Dept. of Dermatology, The Finsen Institute, Copenhagen. (Chief: Poul V. Marcussen, M.D.) Search for other works by this author on: Oxford Academic Google Scholar P. V. MARCUSSEN P. V. MARCUSSEN Dept. of Dermatology, The Finsen Institute, Copenhagen. (Chief: Poul V. Marcussen, M.D.) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 72, Issue 5, 1 May 1960, Pages 173–178, https://doi.org/10.1111/j.1365-2133.1960.tb13870.x Published: 01 May 1960
EXTRA-DURAL ABSCESS FROM MASTOID EMPYEMIA.
Authors: B. ALEXANDER RANDALL
Journal: JAMA (1896)

When the presence of a "mastoid abscess," declared by the occurrence of a fluctuating collection of pus on the surface of the skull behind the ear, only caused the surgeon to incise and evacuate the abscess, we heard little of extra-dural or cerebral abscess except as a curiosity of the postmortem room. Even when the farther step of opening the mastoid became more common, it was so often merely in the interest of better evacuation and drainage that exploration for the remoter extensions of the lesions was rare. It is only since we have more generally adopted the idea urged by all experienced operators, that every possible trace of the pathologic condition shall be extirpated at the operation in the effort to secure immediate cure, that the relative frequency of extra-dural abscess has been recognized. The earlier operators looked upon the middle cerebral fossa and the sigmoid sulcus as regions
Efficient production of human FVIII in hemophilic mice using lentiviral vectors
Authors: Neeltje A Kootstra, Ryusuke Matsumura, Inder M Verma
Journal: Molecular Therapy (2003)

Lentiviral vectors (LV) have the ability to integrate their proviral DNA containing a therapeutic gene into the host cell's genome. Therefore, these vectors have a great potential for gene therapy especially in the treatment of hereditary diseases like hemophilia A, which require lifelong expression of the transgene. We constructed an HIV-1-based LV containing human B-domain-deleted factor VIII (FVIII) cDNA under the control of a promoter consisting of the chicken β-actin promoter, CMV enhancers, and a large synthetic intron (CAG), which is a robust transcription promoter. High levels of FVIII expression from this vector could be demonstrated in vitro in 293T cells, primary liver cells, and hematopoietic progenitor cells. To test whether this viral vector was able to correct the bleeding disorder of C57BL/6 FVIII knockout mice, we transduced these mice with the FVIII LV either by intraperitoneal injection or by transplantation with transduced syngeneic bone marrow. FVIII production was analyzed in the blood plasma for a period of 3 months; however, only low levels of FVIII (<50 mU), which were below 5% of normal FVIII levels of 1000 mU, could be detected. Further analysis revealed that the low levels of FVIII activity present in the blood plasma were due to the presence of neutralizing antibodies to FVIII and not due to lack of expression of FVIII from the viral vector. FVIII expression could be detected in the tissues of the transduced mice by Western blot analysis and in ex vivo cultures. These data demonstrate that LVs are able to produce therapeutic levels of FVIII in knockout mice when administered by ip infection or by transduced hematopoietic cells. The challenge is to overcome the immune barriers to the therapeutic gene product.
Medical Histories of Confederate Generals
Authors: Michael A. Franchetti
Journal: JAMA (1997)

<b>Medical Histories of Union Generals</b>, by Jack D. Welsh, 422 pp, $35, ISBN 0-87338-552-7, Kent, Ohio, Kent State University Press, 1996. I had hoped that these volumes would provide in-depth medical histories of the most influential soldiers of the Civil War but was delighted when I found they make interesting and entertaining reading as well. The books are not a simple chronology of Union and Confederate generals' injuries, illnesses, and treatment but rather are easy to follow and often detailed and graphic accounts. The description of the Union general Cassius Clay's assassination attempt illustrates: "In 1843, Clay was attacked by a paid assassin, Samuel M. Brown. Brown fired his pistol at Clay, who severely cut Brown's face with his bowie knife. A bullet was aimed at Clay's breast, but a knife scabbard, strapped to his chest with a silverlined point, was hit instead and his chest was
The Making of Mr. Gray’s Anatomy: Bodies, Books, Fortune, Fame
Authors: Helen J. Blackman
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Reluctant Doctor Shopper
Authors: Neal L. Sklaver
Journal: Annals of Internal Medicine (1998)

Letters1 May 1998A Reluctant Doctor ShopperNeal L. Sklaver, MDNeal L. Sklaver, MDDallas, TX 75231Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-9-199805010-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a practicing internist, I was disturbed to read the essay “A Reluctant Doctor Shopper” by June Bingham [1]. I was particularly disturbed because an organization such as the American College of Physicians chose to publish an article that was so flagrantly biased and unfair to the author's private physician. As a physician who tries to be responsive to patients, I could empathize with the physician that Ms. Bingham was chastising, because I felt that her demands were both unfair and unrealistic. Among these unrealistic demands were the following:1. The author asked that a medical problem ...References1. Bingham J. A reluctant doctor shopper. Ann Intern Med. 1997; 127:569-70. Google Scholar Author, Article, and Disclosure InformationAffiliations: Dallas, TX 75231 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1998Volume 128, Issue 9Page: 785KeywordsAdolescentsPacemakersReasoning Issue Published: 1 May 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Comparison of Sublingual Immunotherapy (SLIT) versus Oral Immunotherapy (OIT) in the Treatment of Peanut Allergy
Authors: S.J. Chin, E.H. Kim, M.D. Kulis, P. Varshney, P. Steele, J. Kamilaris, A. Hiegel, S.K. Carlisle, A.M. Scurlock, P.B. Smith, B.P. Vickery, S.M. Jones, A.W. Burks
Journal: Journal of Allergy and Clinical Immunology (2012)
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
Authors: Daniel J. DeAngelo, Daohai Yu, Jeffrey L. Johnson, Steven E. Coutre, Richard M. Stone, Alison T. Stopeck, Jon P. Gockerman, Beverly S. Mitchell, Frederick R. Appelbaum, Richard A. Larson
Journal: Blood (2007)
V-Mail: Letters of a World War II Combat Medic (Pfc. Keith Winston)
Authors: Alvin M. Cotlar
Journal: JAMA (1986)

Somewhere in Germany, May 1986.... I stopped jogging on this cool Saturday afternoon, long enough to rest on one of the benches placed by the local citizens on the side of this Eifel mountain road overlooking the valley where we live. I can see the church rising above the houses and shops of picturesque Welschbillig. It is a good place to stop and think about the book<i>V-Mail</i>, although the scene is much more peaceful now than it was just over 40 years ago, when American fighting forces came through from France and Luxembourg, a few kilometers away. But one can feel the nearness of those events—perhaps because of the old stone barns and the generations-old farms that have endured unchanged. "a quiet, home-loving insurance man converted to a combat medic, wounded and decorated for valor" I was about 12 years old in March 1944 when Keith Winston, at age
A1C: Does One Size Fit All?
Authors: Robert M. Cohen
Journal: Diabetes Care (2007)

Diabetes specialists almost uniformly nod their heads when I ask whether they see patients whose A1C results don't match their blood glucose monitoring data. Providers used to attribute that to unreliability of the monitors or the patient records, but technological advances overcame those barriers. Some mismatches can be attributed to inadequate temporal distribution of glucose sampling, and those will be easier to define as continuous glucose monitoring is used more widely, but a substantial number still remain unexplained. That has led to a controversy as to the role of remaining sources of variation in A1C in the routine patient in whom there is no obvious condition known to influence A1C values, i.e., hemoglobinopathy, red cell disorder, or renal failure known to alter either mean age of circulating red cells or hemoglobin chromatographic properties; or the rare drug that modifies A1C by a variety of mechanisms. Without such pathology, does the fact that such variation remains suggest that our standard A1C goals for glycemic control do not in fact fit all individuals with diabetes? Is it indeed valid to equate A1C and mean blood glucose as has become common?

There is one view that proposes a “high glycator–low glycator” hypothesis (1–9) to explain how apparently equivalent glycemic control could result in differing A1C values. The hypothesis is based on the observation that while most individuals in a population with a given mean blood glucose will have A1C within a fairly narrow expected range, there are subsets who have a consistently higher or consistently lower value. These could be due to corresponding alterations either in the relative rate of intracellular glycation or deglycation or in the rate of hemoglobin (red cell) turnover. How large a problem does this have to be to have widespread clinical implications? Even if only 5% …