Angiotensin Converting Enzyme Inhibitors: The End of End-Stage Renal Disease?
Authors: Peter U. Feig
Journal: Annals of Internal Medicine (1989)

Editorials15 September 1989Angiotensin Converting Enzyme Inhibitors: The End of End-Stage Renal Disease?Peter U. Feig, MD, Gale H. Rutan, MD, MPHPeter U. Feig, MDSearch for more papers by this author, Gale H. Rutan, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-451 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMore than 30 000 persons annually develop end-stage renal disease as a result of inexorably progressive renal insufficiency. Because of successful development and funding of maintenance therapy, over 120 000 patients live either on chronic dialysis or with renal allografts. The program has high morbidity and costs about $3 billion per year, that is, approximately $25 000 per patient. Further successes in prolonging life on maintenance therapy without affecting the rate of development of renal failure will result in further increases in this number, with the fastest growth among persons over age 65 (1). Arresting the progression of renal deterioration...References1. Eggers P. Effect of transplantation on the Medicare end-stage renal disease program. N Engl J Med. 1988;318:223-9. CrossrefMedlineGoogle Scholar2. KeaneAndersonAurellde ZeeuwNarinsPovar WSMDRG. Angiotensin converting enzyme inhibitors and progressive renal insufficiency. Current experience and future directions. Ann Intern Med. 1989;111:503-516. LinkGoogle Scholar3. AndersonBrenner SB. Role of intraglomerular hypertension in the initiation and progression of renal disease. In: Kaplan NM, Brenner BM, Laragh JH, eds. The Kidney in Hypertension, v 1. New York: Raven Press; 1987:67-76. Google Scholar4. Fine L. Preventing the progression of human renal disease: have rational therapeutic principles emerged? [Clinical conference]. Kidney Int. 1988;33:116-28. CrossrefMedlineGoogle Scholar5. AndersonMeyerRennkeBrenner STHB. Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest. 1985;76:612-9. CrossrefMedlineGoogle Scholar6. NeugartenKaminetskyFinerSchachtLiuBaldwin JBHRDD. Nephrotoxic serum nephritis with hypertension: amelioration by antihypertensive therapy. Kidney Int. 1985;28:135-9. CrossrefMedlineGoogle Scholar7. HarrisHammondBurkeSchrier DWTR. Verapamil protects against progression of experimental chronic renal failure. Kidney Int. 1987;31:41-6. CrossrefMedlineGoogle Scholar8. Beukersvan der WalHoedemaekerWeening JAPJ. Converting enzyme inhibition and progressive glomerulosclerosis in the rat. Kidney Int. 1987;32:794-800. CrossrefMedlineGoogle Scholar9. Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. Veterans Administration Cooperative Study Group on Antihypertensive Agents. JAMA. 1967;202:1028-34. CrossrefMedlineGoogle Scholar10. DavidovMroczekGavrilovichFinnerty MWLF. Long term follow-up of aggressive medical therapy of accelerated hypertension with azotemia. Angiology. 1975;26:396-407. CrossrefGoogle Scholar11. Cannon P. Medical management of renal scleroderma. N Engl J Med. 1978;299:886-7. CrossrefMedlineGoogle Scholar12. TuckGriffithsJohnsonSternMorley MRLNJ. UCLA geriatric grand rounds. Hypertension in the elderly. J Am Geriatr Soc. 1988;36:630-43. CrossrefMedlineGoogle Scholar13. ParvingAndersenSmidtSvendsen HAUP. Early aggressive antihypertensive treatment reduces rate of decline in kidney function in diabetic nephropathy. Lancet. 1983;1:1175-9. CrossrefMedlineGoogle Scholar14. ChristensenMogensen CC. Effect of antihypertensive treatment on progression of incipient diabetic nephropathy. Hypertension. 1985;7(Suppl 2):II109-113. MedlineGoogle Scholar15. ZatzDunnMeyerAndersonRennkeBrenner RBTSHB. Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J Clin Invest. 1986;77:1925-30. CrossrefMedlineGoogle Scholar16. TagumaKitamotoFutaki YYG. Effect of captopril on heavy proteinuria in azotemic patients. JAMA. 1985;313:1617-20. Google Scholar17. MarreLeblancSuarezGuyenneMenardPassa MHLTJP. Converting enzyme inhibition and kidney function in normotensive diabetic patients with persistent microalbuminuria. Br Med J [Clin Res]. 1987;294:1448-52. CrossrefMedlineGoogle Scholar18. BjorckNybergMulecGranerusHerlitzAurell SGHGHM. Beneficial effects of angiotensin converting enzyme inhibition on renal function in patients with diabetic nephropathy. Br Med J [Clin Res]. 1986;293:471-4. CrossrefMedlineGoogle Scholar19. JacksonCubelaDebreviWhittyJohnston BRLMC. Disparate effects of angiotensin converting enzyme inhibitor and calcium blocker treatment on the preservation of renal structure and function following subtotal nephrectomy or streptozotocin-induced diabetes in the rat. J Cardiovasc Pharmacol. 1987;10(Suppl 10):S167-S169. CrossrefMedlineGoogle Scholar20. MimramInsuaRibsteinMonnierBringerMirouze AAJLJJ. Contrasting effects of captopril and nifedipine in normotensive patients with incipient diabetic nephropathy. J Hypertens. 1988;6:919-23. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisorders of Potassium MetabolismEnalapril reduces the albuminuria of patients with sickle cell diseaseLong-Term Beneficial Effects of Angiotensin-Converting Enzyme Inhibition in Patients With Nephrotic ProteinuriaDrug-Induced Renal DisordersContrasting effects of lisinopril and nifedipine on albuminuria and tubular transport functions in insulin dependent diabetics with nephropathyMolecular Biology of Human Renin and Its GeneInterventions in chronic renal failure.Angiotensin-Converting Enzyme Inhibitors and Renal Function 15 September 1989Volume 111, Issue 6Page: 451-453KeywordsAngiotensin converting enzyme inhibitorMedical dialysisMorbidityRenal failure Issue Published: 15 September 1989 PDF DownloadLoading ...