tbuckley/cabot-search huggingface dataset:
Lung Regional Metabolic Activity and Gas Volume Changes Induced by Tidal Ventilation in Patients with Acute Lung Injury
Authors: Giacomo Bellani, Luca Guerra, Guido Musch, Alberto Zanella, Nicolò Patroniti, Tommaso Mauri, Cristina Messa, Antonio Pesenti
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

During acute lung injury (ALI), mechanical ventilation can aggravate inflammation by promoting alveolar distension and cyclic recruitment-derecruitment. As an estimate of the intensity of inflammation, metabolic activity can be measured by positron emission tomography imaging of [(18)F]fluoro-2-deoxy-D-glucose.To assess the relationship between gas volume changes induced by tidal ventilation and pulmonary metabolic activity in patients with ALI.In 13 mechanically ventilated patients with ALI and relatively high positive end-expiratory pressure, we performed a positron emission tomography scan of the chest and three computed tomography scans: at mean airway pressure, end-expiration, and end-inspiration. Metabolic activity was measured from the [(18)F]fluoro-2-deoxy-D-glucose uptake rate. The computed tomography scans were used to classify lung regions as derecruited throughout the respiratory cycle, undergoing recruitment-derecruitment, and normally aerated.Metabolic activity of normally aerated lung was positively correlated both with plateau pressure, showing a pronounced increase above 26 to 27 cm H(2)O, and with regional Vt normalized by end-expiratory lung gas volume. This relationship did not appear to be caused by a higher underlying parenchymal metabolic activity in patients with higher plateau pressure. Regions undergoing cyclic recruitment-derecruitment did not have higher metabolic activity than those collapsed throughout the respiratory cycle.In patients with ALI managed with relatively high end-expiratory pressure, metabolic activity of aerated regions was associated with both plateau pressure and regional Vt normalized by end-expiratory lung gas volume, whereas no association was found between cyclic recruitment-derecruitment and increased metabolic activity.
Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases
Authors: Gabriel Choukroun, Roger Hajjar, Stefanie Fry, Federica del Monte, Syed Haq, J. Luis Guerrero, Michael Picard, Anthony Rosenzweig, Thomas Force
Journal: Journal of Clinical Investigation (1999)

Cardiac hypertrophy often presages the development of heart failure. Numerous cytosolic signaling pathways have been implicated in the hypertrophic response in cardiomyocytes in culture, but their roles in the hypertrophic response to physiologically relevant stimuli in vivo is unclear. We previously reported that adenovirus-mediated gene transfer of SEK-1(KR), a dominant inhibitory mutant of the immediate upstream activator of the stress-activated protein kinases (SAPKs), abrogates the hypertrophic response of neonatal rat cardiomyocytes to endothelin-1 in culture. We now report that gene transfer of SEK-1(KR) to the adult rat heart blocks SAPK activation by pressure overload, demonstrating that the activity of cytosolic signaling pathways can be inhibited by gene transfer of loss-of-function mutants in vivo. Furthermore, gene transfer of SEK-1(KR) inhibited pressure overload–induced cardiac hypertrophy, as determined by echocardiography and several postmortem measures including left ventricular (LV) wall thickness, the ratio of LV weight to body weight, cardiomyocyte diameter, and inhibition of atrial natriuretic factor expression. Our data suggest that the SAPKs are critical regulators of cardiac hypertrophy in vivo, and therefore may serve as novel drug targets in the treatment of hypertrophy and heart failure.
RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia
Authors: Jeffrey W. Tyner, Denise K. Walters, Stephanie G. Willis, Mary Luttropp, Jason Oost, Marc Loriaux, Heidi Erickson, Amie S. Corbin, Thomas O'Hare, Michael C. Heinrich, Michael W. Deininger, Brian J. Druker
Journal: Blood (2007)
Methaqualone abuse implicated in injuries, deaths nationwide
Authors: Elizabeth Rasche González
Journal: JAMA (1981)

To X o youthful drug users, the seductive white tablets represent "luding out." They promise a "high" superior to that offered by barbiturates, a drunk without the impotence or the hangover, an aphrodisiacal experience. While these properties of methaqualone—known by the US trade name Quaaludes or, in street-parlance, "ludes"—are probably largely mythical, the ill effects of methaqualone abuse are as real as the "luded" adolescents now arriving at hospital emergency rooms and at morgues in record numbers. These youngsters present with life-threatening toxicity from overdosage, fatal personal injury, or a severe withdrawal syndrome that can progress to convulsions. Methaqualone is now the leading drug of abuse next to marijuana, notes Gene Haislip, director, Office of Compliance and Regulatory Affairs, US Drug Enforcement Administration (DEA). In terms of causing injuries, he adds, the drug is now outstripping even heroin and cocaine on the illicit market in 13 major cities throughout the
Assessment of Thiopurine S-Methyltransferase Activity in Patients Prescribed Thiopurines: A Systematic Review
Authors: Ronald A. Booth, Mohammed T. Ansari, Evelin Loit, Andrea C. Tricco, Laura Weeks, Steve Doucette, Becky Skidmore, Margaret Sears, Richmond Sy, Jacob Karsh
Journal: Annals of Internal Medicine (2011)

Background: The evidence for testing thiopurine S-methyltransferase (TPMT) enzymatic activity or genotype before starting therapy with thiopurine-based drugs is unclear. Purpose: To examine the sensitivity and specificity of TPMT genotyping for TPMT enzymatic activity, reducing harm from thiopurine by pretesting, and the association of thiopurine toxicity with TPMT status in adults and children with chronic inflammatory diseases. Data Sources: MEDLINE, EMBASE, the Cochrane Library, and Ovid HealthSTAR (from inception to December 2010) and BIOSIS and Genetics Abstracts (to May 2009). Study Selection: Two reviewers screened records and identified relevant studies in English. Data Extraction: Data on patient characteristics, outcomes, and risk for bias were extracted by one reviewer and independently identified by another. Data Synthesis: 54 observational studies and 1 randomized, controlled trial were included. Insufficient evidence addressed the effectiveness of pretesting. Genotyping sensitivity to identify patients with low and intermediate TPMT enzymatic activity ranged from 70.33% to 86.15% (lower-bound 95% CI, 54.52% to 70.88%; upper-bound CI, 78.50% to 96.33%). Sparse data precluded estimation of genotype sensitivity to identify patients with low to absent enzymatic activity. Genotyping specificity approached 100%. Compared with noncarriers, heterozygous and homozygous genotypes were both associated with leukopenia (odds ratios, 4.29 [CI, 2.67 to 6.89] and 20.84 [CI, 3.42 to 126.89], respectively). Compared with intermediate or normal activity, low TPMT enzymatic activity was significantly associated with myelotoxicity and leukopenia. Limitation: Available evidence was not rigorous and was underpowered to detect a difference in outcomes. Conclusion: Insufficient evidence addresses the effectiveness of TPMT pretesting in patients with chronic inflammatory diseases. Estimates of the sensitivity of genotyping are imprecise. Evidence confirms the known associations of leukopenia or myelotoxicity with reduced TPMT activity or variant genotype. Primary Funding Source: Agency for Healthcare Research and Quality.
Research Results: Preserving Newborn Blood Samples
Authors: Michelle Huckaby Lewis, Michael E. Scheurer, Robert C. Green, Amy L. McGuire
Journal: Science Translational Medicine (2012)

Retention and use, without explicit parental permission, of residual dried blood samples from newborn screening has generated public controversy over concerns about violations of family privacy rights and loss of parental autonomy. The public debate about this issue has included little discussion about the destruction of a potentially valuable public resource that can be used for research that may yield improvements in public health. The research community must advocate for policies and infrastructure that promote retention of residual dried blood samples and their use in biomedical research.
No Effect of Transcendental Meditation on Left Ventricular Function
Authors: ARNOLD GASH
Journal: Annals of Internal Medicine (1978)

Brief Reports1 February 1978No Effect of Transcendental Meditation on Left Ventricular FunctionARNOLD GASH, M.D., JOEL S. KARLINER, M.D., F.A.C.P.ARNOLD GASH, M.D.Search for more papers by this author, JOEL S. KARLINER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-2-215 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are few studies of the direct physiologic effects of transcendental meditation (TM). Because of the complex interactions between psychophysiologic processes and cardiovascular responses, we have studied the immediate cardiovascular effects of TM in healthy volunteers who are regular practitioners of this technique.The study population comprised 26 volunteers, aged 22 to 37. Fifteen were women. None had evidence of organic heart disease by history, physical examination, or resting electrocardiogram or echocardiogram. All subjects had been regular practitioners of TM for at least 1 year. The study was done in an echocardiography laboratory, which afforded quiet and private surroundings. Satisfactory...References1. HIRSHLEIFERCRAWFORDO'ROURKEKARLINER JMRJ: Influence of acute alterations in heart rate and systemic arterial pressure on echocardiographic measures of left ventricular performance in normal human subjects. Circulation 52:835-841, 1975 CrossrefMedlineGoogle Scholar2. WALLACEBENSONWILSON RHA: A wakeful hypometabolic physiologic state. Am J Physiol 221:795-799, 1971 CrossrefMedlineGoogle Scholar3. JEVNINGSMITHWILSON RRA: Alterations in blood flow during transcendental meditation (abstract). Clin Res 24:139A, 1976 Google Scholar4. BLACKWELLBLOOMFIELDGARTSIDEROBINSONHANENSONMAGENHEINNIDICHZIGLER BSPAIHSR: Transcendental meditation in hypertension. Individual response patterns. Lancet 1:223-226, 1976 CrossrefMedlineGoogle Scholar5. POLLACKCASEWEBERLARAGH ADMJ: Limitations of transcendental meditation in the treatment of essential hypertension. Lancet 1:71-73, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARNOLD GASH, M.D.; JOEL S. KARLINER, M.D., F.A.C.P.Affiliations: Division of Cardiology University of California San Diego; San Diego, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySide effects of chronic lithium therapy in Hong Kong Chinese: An ethnopsychiatric perspective 1 February 1978Volume 88, Issue 2Page: 215-216KeywordsCardiovascular therapyEchocardiographyElectrocardiographyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1978 PDF downloadLoading ...
Adiponectin gene polymorphism (G276T) is not associated with incipient diabetic nephropathy in Japanese type 2 diabetic patients
Authors: Keiji Yoshioka, Toshihide Yoshida, Tsunekazu Umekawa, Akinori Kogure, Yasuto Takakura, Hitoshi Toda, Toshikazu Yoshikawa
Journal: Metabolism (2004)
Treatment of chronic urticaria with a proteinase (kallikrein) inhibitor
Authors: N. BEROVA, I. PETKOV, V.C. ANDREEV
Journal: British Journal of Dermatology (2006)

Results are reported of Trasylol treatment of fifty-two patients with various forms of urticaria. 100,000 anti-kallikrein units were given intravenously every other day, with 15–20 injections per course. An excellent therapeutic effect was obtained in 44% (twenty-three patients), and another 37% (nineteen patients) were greatly improved. Additional evidence of the objective therapeutic benefit was obtained in a double-blind study (twenty patients).
Corynebacterium hemolyticum and Pharyngitis
Authors: JAMES L. GREENMAN
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 April 1987Corynebacterium hemolyticum and PharyngitisJAMES L. GREENMAN, M.D.JAMES L. GREENMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-4-633_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Miller and associates (1) make assumptions and conclusions regardingCorynebacterium hemolyticumwithout any control group. They assume thatC. hemolyticumwas the cause of the pharyngitis whenever it was cultured, with the exception of seven patients whose cultures also grew beta-hemolytic non-group AStreptococciorHaemophilus influenzae. Without a control group showing the incidence of asymptomatic carriage in a similar group of people, or aggressive viral culturing, no conclusions about the incidence ofC. hemolyticumcausing pharyngitis can be made. It is well known that some adenovirus strains can cause a pharyngitis indistinguishable from "strep throat" and...References1. MILLERBRANCATOHOLMES RFK. Corynebacterium hemolyticum as a cause of pharyngitis and scarlatiniform rash in young adults. Ann Intern Med. 1986;105:867-72. LinkGoogle Scholar2. MANDELLDOUGLASBENNETT GRJ eds. Principles and Practice of Infectious Diseases. New York: John Wiley & Sons; 1985:1176. Google Scholar1. BANCKNYMAN GM. Tonsillitis and rash associated with Corynebacterium haemolyticum. J Infect Dis. 1986;154:1037-40. CrossrefMedlineGoogle Scholar2. FELLNAGINGTONNAYLOROLDS HJGR. Infections of man with Corynebacterium haemolyticum [Abstract]. J Med Microbiol. 1973;6:vii. Google Scholar3. FENNERWHITE FD. Medical Virology. 2nd ed. New York: Academic Press; 1976:292. Google Scholar4. CRAWFORDBRANCATOHOLMES GFK. Streptococcal pharyngitis: diagnosis by Gram stain. Ann Intern Med. 1979;90:293-7. LinkGoogle Scholar5. SELANDERLJUNGH BA. Corynebacterium haemolyticum as a cause of nonstreptococcal pharyngitis [Letter]. J Infect Dis. 1986;154:1041. CrossrefMedlineGoogle Scholar6. FELLNAGINGTONNAYLOROLDS HJGR. Corynebacterium haemolyticum infections in Cambridgeshire. J Hyg (Camb). 1977;79:269-74. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES L. GREENMAN, M.D.Affiliations: Montefiore Medical Center Bronx, NY 10467 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byArcanobacterium hemolyticum infection: Confused with scarlet fever and diphtheriaThe recognition and significance of Arcanobacterium haemolyticum 1 April 1987Volume 106, Issue 4Page: 633-633KeywordsGroup A streptococciHaemophilus influenzaePharyngitisPharynx ePublished: 1 December 2008 Issue Published: 1 April 1987 PDF downloadLoading ...
V. Outcome Results in Psychological Tests
Authors: Ulrich Stuhr, Adolf-Ernst Meyer, Waltraud Bolz
Journal: Psychotherapy and Psychosomatics (1981)

Research Articles| February 16 2010 V. Outcome Results in Psychological Tests Subject Area: Psychiatry and Psychology Ulrich Stuhr; Ulrich Stuhr Search for other works by this author on: This Site PubMed Google Scholar Adolf-Ernst Meyer; Adolf-Ernst Meyer Search for other works by this author on: This Site PubMed Google Scholar Waltraud Bolz Waltraud Bolz Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1981) 35 (2-3): 138–198. https://doi.org/10.1159/000287488 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ulrich Stuhr, Adolf-Ernst Meyer, Waltraud Bolz; V. Outcome Results in Psychological Tests. Psychother Psychosom 31 December 1981; 35 (2-3): 138–198. https://doi.org/10.1159/000287488 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1981Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Extended Childhood Intervention Prepares Children for School and Beyond
Authors: Edward Zigler
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family Intervention Approach to Loss of Clinical Effect During Antidepressant Treatment
Authors: S. Fabbri
Journal: Psychotherapy and Psychosomatics (2004)

Letters| February 10 2004 Family Intervention Approach to Loss of Clinical Effect During Antidepressant Treatment Subject Area: Psychiatry and Psychology S. Fabbri S. Fabbri Department of Psychology, University of Bologna, Italy Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (2004) 73 (2): 124. https://doi.org/10.1159/000075544 Article history Published Online: February 10 2004 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation S. Fabbri; Family Intervention Approach to Loss of Clinical Effect During Antidepressant Treatment. Psychother Psychosom 1 April 2004; 73 (2): 124. https://doi.org/10.1159/000075544 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 2004Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.