Sella Turcica Enlargement and Primary Adrenal Insufficiency
Authors: ROBERT G. DLUHY
Journal: Annals of Internal Medicine (1978)

Brief Reports1 October 1978Sella Turcica Enlargement and Primary Adrenal InsufficiencyROBERT G. DLUHY, M.D., THOMAS J. MOORE, M.D., GORDON H. WILLIAMS, M.D., F.A.C.P.ROBERT G. DLUHY, M.D., THOMAS J. MOORE, M.D., GORDON H. WILLIAMS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-513 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSella turcica enlargement is a well-established complication of prolonged, primary hypothyroidism (1, 2). Because enlargement of the sella turcica has also been reported in untreated patients with primary gonadal insufficiency (for example, Klinefelter's and Turner's syndromes) (3, 4), it has been hypothesized that prolonged target-hormone insufficiency may lead to hyperplastic or adenomatous transformation of the pituitary trophic cells. Our report adds evidence for this hypothesis, documenting for the first time sella turcica enlargement in two patients with primary adrenal insufficiency.Patient 1: A 21-year-old man presented in 1939 with a 2-year history of increasing skin pigmentation, salt-craving, and a 16-kg...References1. VAN WYCKGRUMBACH JM: Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism: an example of hormonal overlap in pituitary feedback. J Pediatr 57:416-433, 1960 CrossrefGoogle Scholar2. VAGENAKISDOLEBRAVERMAN AKL: Pituitary enlargement, pituitary failure and primary hypothyroidism. Ann Intern Med 85:195-198, 1976 LinkGoogle Scholar3. BURTREINERCOHENSNIFFEN ALRR: Klinefelter's syndrome: report of an autopsy, with particular reference to the histology and histochemistry of the endocrine glands. J Clin Endocrinol Metab 14:719-728, 1954 CrossrefMedlineGoogle Scholar4. KELLY L: Ovarian dwarfism with pituitary tumor. J Clin Endocrinol Metab 23:50-53, 1963 CrossrefMedlineGoogle Scholar5. DI CHIRONELSON GK: The volume of the sella turcica. Am J Rentgenol 87:989-1007, 1962 Google Scholar6. MOOREBRACKNEYBOCK GEF: Production of pituitary tumors in mice by chronic administration of thiouracil derivative. Proc Soc Exp Biol Med 82:643-645, 1953 CrossrefMedlineGoogle Scholar7. FURTHDENTBURNETTGADSDEN JNWE: The mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy. J Clin Endocrinol Metab 15:81-97, 1955 CrossrefMedlineGoogle Scholar8. NELSONMEAKINDEALYMATSONEMERSONTHORN DJJDKG: ACTH-producing tumor of the pituitary gland. N Engl J Med 259:161-164, 1958 CrossrefMedlineGoogle Scholar9. MOOREDLUHYWILLIAMSCAIN TRGJ: Nelson's syndrome: frequency, prognosis and effect of prior pituitary irradiation. Ann Intern Med 85:731-734, 1976 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Peter Bent Brigham Hospital Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAddison's Disease and Pituitary EnlargementCushing's disease in a patient with steroid 21-hydroxylase deficiencyPituitary corticotroph adenoma in a woman with long-standing addison's disease: A histologic, immunocytochemical, electron microscopic, andIn Situ hybridization studyCorticotroph cell hyperplasia in a patient with addison disease: Case reportPartially compensated hypoadrenalism presenting with persistent skin pigmentationAddison's disease and empty sellaAddison's DiseaseAUTOIMMUNE POLYGLANDULAR SYNDROME, PRIMARY EMPTY SELLA, AND ACUTE LYMPHOCYTIC LEUKAEMIAAUTO-IMMUNE ADDISON'S DISEASE ASSOCIATED WITH HYPERPROLACTINAEMIAVolume of sella turcica in normals and patients with peripheral endocrinopathies or idiopathic gonadotropin deficiencyAN ACTH-SECRETING PITUITARY TUMOUR ARISING IN A PATIENT WITH CONGENITAL ADRENAL HYPERPLASIAPrimary empty sella syndrome, ACTH hypersecretion, and normal adrenocortical functionCortisol Suppression Test in Patients with Elevated Adrenocorticotropic Hormone LevelsRICHARD J. KOLETSKY, M.D., ROBERT G. DLUHY, M.D., FRANK R. CRANTZ, M.D., GORDON H. WILLIAMS, M.D.ADRENOCORTICAL TUMOUR IN UNTREATED CONGENITAL ADRENOCORTICAL HYPERPLASIA ASSOCIATED WITH INADEQUATE ACTH SUPPRESSIBILITYGeneralized Diseases and Changes in the Sella Turcica 1 October 1978Volume 89, Issue 4Page: 513-514KeywordsCellsHypothyroidismTurner syndrome Issue Published: 1 October 1978 PDF DownloadLoading ...