tbuckley/cabot-search huggingface dataset:
Perioral dermatitis in a patient with myasthenia gravis following systemic corticosteroid treatment
Authors: J.M. Goss, K.M. Nord, M.R. Olarte, M.E. Grossman
Journal: British Journal of Dermatology (2006)

Journal Article Perioral dermatitis in a patient with myasthenia gravis following systemic corticosteroid treatment Get access J.M. Goss, J.M. Goss Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. Departments of *Dermatology and †Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar K.M. Nord, K.M. Nord Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. Departments of *Dermatology and †Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M.R. Olarte, M.R. Olarte Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. Departments of *Dermatology and †Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M.E. Grossman M.E. Grossman Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. Departments of *Dermatology and †Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. Correspondence: Marc E. Grossman. E‐mail: marcmeg9@aol.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 3, 1 March 2007, Page 582, https://doi.org/10.1111/j.1365-2133.2006.07668.x Published: 01 March 2007
De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome
Authors: Toshinobu Matsuura, James S. Sutcliffe, Ping Fang, Robert-Jan Galjaard, Yong-hui Jiang, Claudia S. Benton, Johanna M. Rommens, Arthur L. Beaudet
Journal: Nature Genetics (1997)
Immunologic mechanisms of parenchymal lung injury.
Authors: W F Willoughby, J B Willoughby
Journal: Environmental Health Perspectives (1984)

The lung, like most other organs, is susceptible to injury by circulating immune complexes, and also by humoral autoantibody and immune lymphocytes which specifically recognize selected lung antigens. In addition, by virtue of its direct communication with the external environment, the lung can also be injured by inhaled environmental agents which trigger inflammatory reactions mediated by immune effector systems. Although major emphasis to date has been placed on the ability of inhaled antigens to first sensitize, then provoke, immunologically specific reactions in the lung, there is increasing evidence to show that these same immune effector systems are also triggered in an immunologically nonspecific fashion by a certain environmental agents (termed "mitogens") which activate leukocytes in a polyclonal fashion. Such agents include certain viruses and other microorganisms, bacterial endotoxin, a wide variety of plant lectins, and certain chemicals, such as the phorbol esters. Although such agents act in an immunologically nonspecific fashion, they are nonetheless quite specific from a chemical viewpoint, and in many cases act by binding to specific receptors on the cell surface. By activating macrophages directly, and by activating much larger percentages of a given lymphocyte population than do specific antigens, they induce correspondingly amplified inflammatory reactions in vivo. Recent studies with animal models indicate that inhaled mitogens are strikingly effective in inducing pulmonary inflammation, whereas inhaled antigens (lacking mitogenic activity) produce little if any parenchymal injury in immunized recipients, unless administered in conjunction with a mitogen. Ongoing studies using such models promise to provide valuable new insight into the biologic properties which govern the pathogenicity of inhaled environmental agents, the mediators they release, and the biochemical basis for variations in individual susceptibility to injury by such agents.
Abstract LB-434: Colorectal, prostate, and skin cancer screening among Hispanic and white non-Hispanic men, 2000-2005
Authors: Zhou Jing, Lindsey Enewold, George E. Peoples, David G. McLeod, John F. Potter, Scott R. Steele, Kevin S. Clive, Alexander Stojadinovic, Kangmin Zhu
Journal: Cancer Research (2010)

Abstract One of the most effective means of reducing cancer-specific mortality is early detection via cancer screening; however, Hispanic men continue to have lower colorectal, prostate and skin cancer screening rates than White non-Hispanic men. To combat this disparity and educate men and women aged 50 and older about the importance of regular colorectal cancer (CRC) screening, the Screen for Life campaign, which included directed intervention materials in Spanish as well as in English, was launched by the Center for Disease Control and Prevention (CDC) in 1999. We hypothesized that CRC screening rates would increase overtime among Hispanics and non-Hispanics as a result of this campaign and that prostate and skin cancer screening would also increase due to screening recommendations and raised awareness and necessity of cancer screening. The objective of this study was to assess whether CRC, as well as prostate and skin cancer screening rates among Hispanic and White non-Hispanic men changed between 2000 and 2005 using the National Health Interview Survey (NHIS) data. Our results showed that Hispanic men were less likely to comply with cancer screening guidelines for these three common malignancies than White non-Hispanic men. However, significant increases in CRC endoscopic screening were observed in both ethnic groups. It increased 2.1-fold and 2.4-fold for Hispanic and White non-Hispanic men, respectively (P&amp;lt;0.05). In contrast, the use of home fecal occult blood tests remained stable among Hispanics and decreased significantly among White non-Hispanics. PSA screening remained stable, while the use of skin cancer screening tended to increase among both ethnic groups. Our study suggests that a targeted public education program that is culturally sensitive and linguistically appropriate may be effective in increasing CRC screening rates. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-434.
Polyostotic Fibrous Dysplasia on F-18 FDG PET/CT Imaging
Authors: Maria M. D'Souza, Abhinav Jaimini, Aditi Khurana, Madhavi Tripathi, Rajnish Sharma, Anupam Mondal, Madhur Srivastava
Journal: Clinical Nuclear Medicine (2009)

A 13-year-old girl diagnosed as polyostotic fibrous dysplasia on plain radiography and histopathology presented with diffuse bone pain. F-18 FDG PET/CT scan was performed to establish the extent of bone involvement, which revealed increased radiotracer uptake at multiple sites. The CT images clearly depicted the extent of each individual lesion along with associated complications. The volume rendered images provided an excellent 3-dimensional representation of the entire skeletal system. Bone scintigraphy, plain radiography, and CT scans are the traditionally employed imaging modalities for evaluation of this rare entity. F-18 FDG PET/CT with its superior spatial resolution and added advantage of lesion characterization could serve as a 1-stop shop for evaluation of this unusual disease.
Bless you! Sneezing and the seven deadly sins
Authors: Bill Davidson
Journal: Journal of the Royal Society of Medicine (2009)

I chanced upon the fascinating article by Bhutta and Maxwell1 following a recent conversation with friends. One of them sneezes in response to sexual ideation (and sunlight), another in response to fullness of the stomach.

I now wonder whether the expression ‘Bless you!’ originated in once common knowledge, now lost, that sneezing had this association with sexual ideation (or ‘lust’) and fullness of stomach (or ‘gluttony’).

I suggest this because a third acquaintance also sneezes for no self-reported reason, though the rest of us think it could well be ‘sloth’.
Endoscopic Ultrasound–Guided Trucut Biopsy of the Cyst Wall for Diagnosing Cystic Pancreatic Tumors
Authors: M LEVY, T SMYRK, R REDDY, J CLAIN, G HAREWOOD, M KENDRICK, R PEARSON, B PETERSEN, E RAJAN, M TOPAZIAN
Journal: Clinical Gastroenterology and Hepatology (2005)
Comparative studies on the in vivo effects of tartar emetic, vitamin B6, and the chelating agent 2,3-dimercaptopropanol (BAL) on the functional capacity of the tryptophan-niacin pathway in patients with schistosomiasis
Authors: F.S. Kelada, G.A. Abdel-Tawab, M.H. Moustafa, A.A. Konbar
Journal: Metabolism (1972)
Variants of the Fatty Acid-Binding Protein 2 Gene Are Not Associated With Coronary Heart Disease in Nondiabetic Subjects and in Patients With NIDDM
Authors: Laura Saarinen, Arto Pulkkinen, Anu Kareinen, Sami Heikkinen, Seppo Lehto, Markku Laakso
Journal: Diabetes Care (1998)

OBJECTIVE To investigate the association of variants of the fatty acid-binding protein (FABP) 2 gene with coronary heart disease (CHD) in nondiabetic subjects and in patients with NIDDM. RESEARCH DESIGN AND METHODS Cross-sectional study included 135 nondiabetic and 79 NIDDM subjects with stenosis (&amp;gt;50%) in at least two coronary arteries. A group of 81 healthy nondiabetic men without CHD served as a control population. All exons and intron-exon junctions of the FABP2 gene were amplified with the polymerase chain reaction, and variants were screened with the single-strand conformation polymorphism analysis. RESULTS The allele frequency of an amino acid polymorphism (alanine→threonine) in codon 54 of exon 2 of the FABP2 gene was 0.26 in nondiabetic subjects with CHD and 0.27 in NIDDM subjects with CHD. Other variants (GTA 118 GTC, GCGCA→GCACA in the 3'- noncoding region, and the number of ATT repeats in intron 2) also did not associate with CHD. CONCLUSIONS The variants of the FABP2 gene are not likely to contribute to the risk of CHD in Finnish nondiabetic and NIDDM subjects.
Advanced heart failure and nocturnal hypoxaemia due to central sleep apnoea are associated with increased serum erythropoietin
Authors: Andrew D. Calvin, Virend K. Somers, David P. Steensma, Jose A. Rio Perez, Christelle van der Walt, Jennifer M. Fitz‐Gibbon, Christopher G. Scott, Lyle J. Olson
Journal: European Journal of Heart Failure (2010)
Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS
Authors: Ganesan Keerthivasan, Yang Mei, Baobing Zhao, Ling Zhang, Chad E. Harris, Juehua Gao, Ashley A. Basiorka, Matthew J. Schipma, James McElherne, Jing Yang, Amit K. Verma, Andrea Pellagatti, Jacqueline Boultwood, Alan F. List, David A. Williams, Peng Ji
Journal: Blood (2014)
Human Insulin (recombinant DNA) in the Treatment of Patients with Newly Diagnosed Insulin-dependent Diabetes Mellitus (IDDM)
Authors: Norbert Lotz, Werner Bachmann, Hellmut Mehnert
Journal: Diabetes Care (1982)

Human insulin (recombinant DNA) was administered subcutaneously to 16 patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM), whereas a control group of 11 patients received highly purified pork insulin (PPI). The control group was only available for the inpatient period, while the HI-treated patients could be observed monthly afterward. For metabolic control, basal and postprandial blood glucose, plasma C-peptide, and HbA1 were measured. During the outpatient period, blood glucose self-monitoring was also performed. Within 6 days of therapy, blood glucose levels were lowered to normal without any statistical differences between the HI and PPI groups. Mean insulin requirement was 35 U/day in both groups. Plasma C-peptide levels were not different at any time. In the human insulin group, HbA1 values were continuously lowered from the initial 13% to the normal range within 2–3 mo and remained normal after 6 mo of therapy. No allergic reaction and no other side effects could be seen. The results suggest that in the first period of treatment, the metabolic situation of patients with IDDM could be well controlled by human insulin as well as by PPI. Human insulin has been proven to be an effective and safe insulin.
Carcinoma of the Vulva
Authors: A. H. Charles
Journal: BMJ (1972)

A series of 127 patients presenting at two London hospitals with carcinoma of the vulva during the period 1948-70 is reviewed. Patients with intraepithelial carcinoma or rodent ulcer are excluded, but the series includes two cases of malignant melanoma, one of adenocarcinoma of Bartholin's gland, and two of basal cell carcinoma. In the remainder the pathological diagnosis was squamous cell carcinoma.Leucoplakia was present in only 30 cases (24%) and it is therefore concluded that this condition is probably not so dangerous as a precursor of cancer as has been stated in the past, though an association with cancer of the vulva is undeniable.In only three cases was no form of treatment practicable. Of the remaining 124, two were treated by radiotherapy, 37 by simple vulvectomy, 12 by vulvectomy followed by separate inguinal lymphadenectomy, and 73 by radical vulvectomy combined with bilateral lymphadenectomy en bloc, pelvic lymphadenectomy being included whenever the superficial lymph nodes appeared to be involved or when Cloquet's node was shown by frozen-section examination to be invaded. Excellent results, with an absolute five-year survival rate of 66%, were obtained with this last procedure, especially when primary skin cover was provided by the delayed technique (five-year survival 73%). The results of simple vulvectomy were also surprisingly good, with an absolute five-year survival rate of 65%, and this operation may be a wise choice for the very old or infirm patient.
But Not Alone: The Grief of Infertility
Authors: Jo Ellen Patterson
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The article entitled "But Not Alone"<sup>1</sup>describes a special kind of grief. Struggling with infertility teaches several lessons about grieving for unfulfilled hopes. Grieving memories such as the death of a family member are different from grieving for a nonexistent child. Ms Bradney notes the first difference by recognizing that there is seldom an end point. Grief theorists point out that irreversible losses can be dealt with effectively, while grieving and simultaneously maintaining hope make resolution impossible.<sup>2</sup> Another difference in grieving memories compared with grieving unfulfilled hopes is that the latter often go unrecognized. The death of a family member is a public event that usually brings friends and family to support the grieving members. A memorial service, visiting the home, and sending flowers are important ways we share the burden of sorrow with the grieving family. Infertility is a private event. There is no
Asbestos fibers in bronchoalveolar lavage and lung tissue of former asbestos workers.
Authors: H Teschler, K H Friedrichs, G B Hoheisel, G Wick, U Soltner, A B Thompson, N Konietzko, U Costabel
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Bronchoalveolar lavage (BAL) provides a simple method of sampling inhaled particles deposited in the lower respiratory tract. We hypothesized that BAL could be used to measure the quantity and quality of lung asbestos burden. This would be true if BAL fluid asbestos fiber content reflected the total content as well as the size distribution of both uncoated and coated asbestos fibers in lung parenchyma. Therefore, we analyzed the asbestos fiber counts of 23 individual sample pairs in both BAL fluid and lung tissue samples obtained from 20 patients with occupational asbestos exposure using transmission electron microscopy (TEM). In addition, fiber type, fiber size, and aspect ratio were compared. Coated asbestos fibers were found in 10 of 23 BAL samples and 16 of 23 biopsies. The mean concentrations of coated asbestos fibers (i.e., asbestos bodies) in BAL and lung parenchyma showed a positive correlation (r = 0.75, p < 0.001). Likewise, the mean amphibole fiber concentrations correlated positively (r = 0.55, p < 0.01). However, there was no relationship between the mean chrysotile fiber counts in BAL and lung parenchyma (r = 0.18, p = 0.40). Asbestos fibers in lung tissue were significantly longer (8.2 +/- 0.5 versus 4.8 +/- 0.6 microns; p < 0.001) but had the same width (0.12 +/- 0.27 versus 0.11 +/- 0.15 microns; p = 0.24) when compared with those retrieved by BAL from the airspace compartment. The aspect ratio (dividing fiber length by width) was much higher in lung tissue than in BAL fluid (66.4 +/- 0.4 versus 42.9 +/- 0.5; p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
Is there still a role for bone scintigraphy in patients with breast cancer selected for systemic staging in the era of multi-detector CT?
Authors: S.R. Tee, D.P. McCartan, J. Rothwell, J. Geraghty, D. Evoy, C.M. Quinn, R.S. Prichard, S. Skehan, A. O'Doherty, E.W. McDermott
Journal: International Journal of Surgery (2014)
A Curious Case of Chest Pain
Authors: Joshua M. Liao, Garrick C. Stewart, Robert F. Padera, Amy Leigh Miller, Joseph Loscalzo
Journal: New England Journal of Medicine (2013)

A 67-year-old man presented to the emergency department with chest pain that had begun earlier that day and had progressed over a period of several hours. The pain was substernal and nonradiating, and it did not change with position or food intake.
Immunisation against chickenpox
Authors: L. F. Ross, J. D Lantos
Journal: BMJ (1995)

fasciotomy.Better demarcation of non-viable tissue makes for precise debridement, and only at this stage may discrimina- tion between a potentially salvageable and an irretrievably damaged limb become clear.Restoration of skeletal integrity will safeguard subsequent vessel repair.The debate over whether artery or vein is repaired first is rendered obsolete.A compound vein graft, matching the calibre of the host vessel,'-36-9 or an extra-anatomic vein graft bypassing an open contaminated wound may be constructed at leisure.9 10 These improvements in managing vascular injuries repre- sent dividends from an experience in which the victims of inhumanity have been the key contributors.The hope remains that "one day the people of peace will come into their own in Northern Ireland."20
Carotid Intima-Media Thickness Is Only Weakly Correlated With the Extent and Severity of Coronary Artery Disease
Authors: Mark R. Adams, Akihiro Nakagomi, Anthony Keech, Jacqui Robinson, Robyn McCredie, Brian P. Bailey, S. Ben Freedman, David S. Celermajer
Journal: Circulation (1995)

Background Intima-media thickness (IMT) of the common carotid artery (CCA), measured with external vascular ultrasound, has been widely used in clinical trials as a surrogate marker for coronary atherosclerosis. Despite this, the degree of correlation between carotid IMT and the extent and severity of coronary artery disease (CAD) is not known. Methods and Results Common carotid IMT was measured by ultrasound in 350 consecutive subjects of age 60±10 years (range, 30 to 85 years) on the day of coronary angiography. Carotid mean IMT was 0.83±0.20 mm (range, 0.43 to 1.80 mm), and maximum IMT was 1.04±0.27 mm (range, 0.49 to 2.19 mm). Coronary angiograms were analyzed by independent observers for disease severity (number of vessels with ≥70% stenosis), extent score, and a modified Gensini score. Mean carotid IMT was weakly but significantly correlated with CAD severity ( r =.26), extent ( r =.23), and modified Gensini score ( r =.29, P &lt;.0001 for all correlations). Carotid IMT was not clinically useful, however, because it was not specific or sensitive enough to identify patients with or without significant CAD. Increasing age, male sex, and presence of diabetes were all associated with a significantly ( P &lt;.01) higher CAD score than the average for any level of carotid IMT, suggesting differential effects of these traditional risk factors on the coronary and common carotid arteries. Conclusions Although carotid IMT is significantly correlated with extent and severity of CAD, the relationship is weak. This relatively poor correlation ( r 2 &lt;.10) should be considered in the interpretation of clinical trials that use carotid IMT as a surrogate end point for coronary atherosclerosis.
Introductory Hearing Science: Physical and Psychological Concepts
Authors: Hubert L. Gerstman
Journal: JAMA (1975)

For many years, the science of audiology has lacked a unified introductory text that satisfactorily defined the relationship of hearing science to the neurologic and behavioral correlates of communication and speech processing. This new compilation provides that bridge while at the same time surveys the background, history, and current state of audiology. Otologists and audiologists will find that this book fills their need for a concise and accurate beginning text that is also useful as a basic reference. It contains contributions from a variety of experienced teachers and clinicians, many of whom are relatively new to the medical literature. The interdisciplinary nature of the subject matter creates a need for input from commercial acoustics, engineering, otology, audiology, psychology, and speech science. Dr. Gerber has edited wisely so that the juxtaposition of the presentations flows in near perfect order.  The text is made up of four major sections: Anatomy and Physiology
Human expression and experience: What does it mean to have language?
Authors: Yves-Marie Visetti, Victor Rosenthal
Journal: Behavioral and Brain Sciences (2002)

We support Shanker &amp; King's (S&amp;K's) proposal for a dynamic systems approach in ape language research, but question their vision of what it means to have language. Language plays an essential role in the making of the human mind. It underlies any kind of human interaction and codetermines perception and action. Moreover, what gives human thought the very characteristic architecture of textuality criterially requires a third party.
ON PALAEOGENETIC FACE - PATTERN IN ACROTERIC PIEBALDS
Authors: J. Hutchinson
Journal: BMJ (1910)

4EHE most casual observer in i London streets must have _ .noticed that many horses hive stars, or streaks of white, on their faces.It may, however, evoke a smile of amused incredulity if it is asserted that these markings sometimes have their repre - _sentatives on the human l|-ll 11| * ~face.|ln the first place let me point out that there patches may differ much in size and contour, and although usually in W Broad forehead, streak on faee of the middle line, and horse prolonged upon the upper lip b andshowingalsoon lowerlip.White bilaterally symmetricaJ, stockings occurred on all four feet,
The Media and Health Care Reform
Authors: Noam N. Levey
Journal: JAMA (2013)

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