tbuckley/cabot-search huggingface dataset:
Sustained activation of blood coagulation in patients with cerebral thrombosis
Authors: Yoshinobu Seki, Hoyu Takahashi, Ken Wada, Akira Shibata
Journal: American Journal of Hematology (1995)

Recent progress in the measurements of the hemostatic markers enables us to assess the detailed profiles of hemostatic activation in various diseases. To evaluate the degree of hemostatic system activation in patients with cerebral thrombosis, detailed coagulation studies were performed in 28 patients with acute-phase cerebral thrombosis and in 36 with chronic-phase cerebral thrombosis, together with 6 with chronic-phase cerebral hemorrhage and 37 age-matched healthy volunteers. In both acute-phase and chronic-phase cerebral thrombosis, plasma levels of thrombin-antithrombin III complex, plasmin-alpha 2-plasmin inhibitor complex and D-dimer were significantly higher, and antithrombin III and protein C were significantly lower than those in the normal group. Plasma fibrinogen concentration was significantly higher in chronic-phase cerebral thrombosis than that in chronic-phase cerebral hemorrhage. No significant difference was found in these variables between acute-phase and chronic-phase cerebral thrombosis. In addition, there was no difference in these parameters between chronic phase cerebral hemorrhage and normal subjects. These findings indicate that a sustained activation of coagulation and fibrinolysis is present in cerebral thrombosis, and it might contribute to the pathogenesis of cerebral thrombosis.
Catheterization of the Pulmonary Artery in Transposition of the Great Arteries
Authors: JOHN M. CELERMAJER, ALEX W. VENABLES, J. DENBY BOWDLER
Journal: Circulation (1970)

A simple method of catheterization of the pulmonary artery in transposition of the great arteries with the use of a "floppy wire" and "J wire" is described. The method can also be used to enter the aorta from the left ventricle in cases in which there is an interatrial communication.
Risk factors of hepatitis during Anti-tuberculous treatment and implications of hepatitis virus load
Authors: Jann-Yuan Wang, Chen-Hua Liu, Fu-Chang Hu, Hsiu-Ching Chang, Jia-Luen Liu, Jong-Min Chen, Chong-Jen Yu, Li-Na Lee, Jia-Horng Kao, Pan-Chyr Yang
Journal: Journal of Infection (2011)
Practice based commissioning is "here to stay," government says
Authors: A. Cole
Journal: BMJ (2009)

The Department of Health has insisted that practice based commissioning is “here to stay,” despite continuing evidence that many GPs in England remain reluctant to take part.

The latest quarterly MORI survey of GPs shows that 73% have now received a practice based budget, 67% have agreed a commissioning plan, and 56% are commissioning services. But support for the policy has actually fallen slightly, from 64% in the last survey to 62% now.

Speaking at the launch of the health department’s new “vision” for practice based commissioning, the national clinical director for primary care, David Colin-Thome, …
Diseases of the gastrointestinal tract and liver
Authors: D. Wingate
Journal: Gut (1982)

1<h3>Abstract</h3> Hybridization between related species results in the formation of an allopolyploid with multiple subgenomes. These subgenomes will each contain complete, yet evolutionarily divergent, sets of genes. Like a diploid hybrid, allopolyploids will have two versions, or homeoalleles, for every gene. Partial functional redundancy between homeologous genes should result in a deviation from additivity. These epistatic interactions between homeoalleles are analogous to dominance effects, but are fixed across subgenomes through self pollination. An allopolyploid can be viewed as an immortalized hybrid, with the opportunity to select and fix favorable homeoallelic interactions within inbred varieties. We present a subfunctionalization epistasis model to estimate the degree of functional redundancy between homeoallelic loci and a statistical framework to determine their importance within a population. We provide an example using the homeologous dwarfing genes of allohexaploid wheat, <i>Rht-1</i>, and search for genome-wide patterns indicative of homeoallelic subfunctionalization in a breeding population. Using the IWGSC RefSeq v1.0 sequence, 23,796 homeoallelic gene sets were identified and anchored to the nearest DNA marker to form 10,172 homeologous marker sets. Interaction predictors constructed from products of marker scores were used to fit the homeologous main and interaction effects, as well as estimate whole genome genetic values. Some traits displayed a pattern indicative of homeoallelic subfunctionalization, while other traits showed a less clear pattern or were not affected. Using genomic prediction accuracy to evaluate importance of marker interactions, we show that homeologous interactions explain a portion of the non-additive genetic signal, but are less important than other epistatic interactions.
445 Severe mitochondrial toxicity after liver transplantation in HIV-HCV coinfected patients
Authors: J DUCLOSVALLEE, C JANDEL, D VITTECOQ, E TEICHER, P ICHAI, F SALIBA, R ADAM, D AZOULAY, C GUETTIER, D CASTAING
Journal: Hepatology (2003)

<dm:abstracts xmlns:dm="http://www.elsevier.com/xml/dm/dtd"><ce:abstract xmlns:ce="http://www.elsevier.com/xml/common/dtd" class="author" xml:lang="en" id="ab005" view="all"><ce:section-title id="st005">Lay summary</ce:section-title><ce:abstract-sec id="as005" view="all"><ce:simple-para id="sp0005" view="all">A rare side effect of ledipasvir/sofosbuvir is liver injury, which occurs within 2-6 weeks of starting treatment. Total and direct bilirubin values are greatly increased, and worsening of liver function may occur; symptoms are usually reversible when treatment is stopped. An interaction with lopinavir/ritonavir may contribute to this adverse effect.</ce:simple-para></ce:abstract-sec></ce:abstract></dm:abstracts>
Report Calls for US Funding to Speed Global Health Research and Innovation
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of xamoterol in Shy-Drager syndrome.
Authors: A Obara, H Yamashita, S Onodera, O Yahara, H Honda, N Hasebe
Journal: Circulation (1992)

BACKGROUND Xamoterol, a cardioselective beta 1-adrenoceptor partial agonist, has been reported to be effective on postural hypotension. We investigated the effect of xamoterol in five patients with Shy-Drager syndrome (SDS) in relation to their prevailing sympathetic nerve activity and sensitivity of beta-adrenoceptors and the change in circadian variation of blood pressure. METHODS AND RESULTS Ambulatory blood pressure over 24 hours was monitored by noninvasive sphygmomanometer (model 5200, Spacelab). Plasma norepinephrine levels of SDS patients were significantly lower than that of normal subjects (n = 5) both at rest (54 +/- 15 versus 178 +/- 83 pg/ml) and after 10-minute standing (74 +/- 24 versus 318 +/- 143 pg/ml). Infusion of isoproterenol (0.02 micrograms/kg/min) produced a mild rise of systolic blood pressure and tachycardia in normal subjects but resulted in marked hypotension and tachycardia in SDS subjects. After xamoterol administration (200 mg b.i.d.), systolic blood pressure and heart rate were significantly increased in the averages during the day; however, increases were more pronounced at night. In two of the five patients, the improvement in dizziness was large enough to enable them to increase their daily activities. CONCLUSIONS Our observations suggest that 1) beta 1-selective, high intrinsic sympathomimetic activity of xamoterol increases blood pressure and heart rate in patients with SDS as a consequence of their prevailing beta 1-adrenoceptor hypersensitive state, and 2) blood pressure monitoring over 24 hours appears to have important advantages in evaluating the therapeutic effects on postural hypotension.
Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas
Authors: Iwona Wlodarska, Daan Dierickx, Vera Vanhentenrijk, Katrien Van Roosbroeck, Helena Pospís̆ilová, Francesca Minnei, Gregor Verhoef, José Thomas, Peter Vandenberghe, Chris De Wolf-Peeters
Journal: Blood (2008)
"Health care is a human right" is a meaningless and devastating manifesto
Authors: I. J P Loefler
Journal: BMJ (1999)

EDITOR—“Health care is a human right,” declares the Tavistock Group.1 If the group accepts the World Health Organisation's definition of health as a “state of complete physical, mental and social well-being” then the demand that the provision of such a state be recognised as a human right will have little meaning.

If the Tavistock Group has an alternative definition of health then it should say so. As long as we are uncertain what the word denotes, “health care” remains a nebulous entity. Whatever the …
Kadayath Abraham George
Authors: R A J Spence
Journal: BMJ (2008)

Kadayath Abraham George (“George”) was born on 7 May 1943 in Vadavacode, a village just outside Cochin, Kerala, South India. He was the youngest of eight children, two boys and six girls. George’s father died at the age of 40, when George was only 2 years old, and was very forward thinking, like his son, beginning a memorial school, the first school in Vadavacode.

George, as he was so fondly known, graduated from Ludhiana Christian Medical College in 1967. He took his DA in 1969 and acquired his MD in 1973, also in the Punjab. He came to Belfast in September 1974 as a senior registrar in anaesthesia. He subsequently became a fellow of the Royal College of Anaesthetists in 1975 and took up his consultant post in anaesthetics in Belfast City Hospital in 1977.

He subsequently took a one year sabbatical in Portland, Oregon, in 1985 as a visiting professor at the Oregon Health Sciences University and Hospital.

For 30 years George gave superb service to his patients in Belfast City Hospital.

During the trauma years of the Troubles in Northern Ireland, he anaesthetised many hundreds of patients wounded by gunshot and bomb blast. …
Healthy, Non-Allergic Subjects Do Not Develop Allergic Symptoms When Co-Mingled with Symptomatic Allergic Subjects and Exposed to Airborne Allergen in an Environmental Exposure Chamber (EEC)
Authors: Rishi Patel, Erin Beattie, Renea Modeste, AnneMarie Salapatek
Journal: Journal of Allergy and Clinical Immunology (2015)
1001-11 Lower doses of hormone replacement therapy did not increase hsC-reactive protein or F1+2 levels but improved flow-mediated dilation in postmenopausal women: A randomized, double-blind, crossover study
Authors: Kwang K Koh, Jeong Y Ahn, Seung H Han, Mi-Seung Shin, Tae H Ahn, Eak K Shin
Journal: Journal of the American College of Cardiology (2004)
Adrenalectomy for Primary Aldosteronism
Authors: David G. Martinez
Journal: Annals of Internal Medicine (2003)

Letters21 January 2003Adrenalectomy for Primary AldosteronismDavid G. Martinez, MDDavid G. Martinez, MDBinghamton, NY 13903 (Martinez)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-2-200301210-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Sawka and colleagues found only a 33% cure rate with adrenalectomy in patients with primary aldosteronism (1). One explanation for this finding could be that some of these patients did not have a functioning adenoma or had concomitant adrenal hyperplasia. Ninety-two percent of Sawka and colleagues' patients reportedly had an adenoma at surgery; however, laboratory data confirming a functioning adenoma were not presented.I cared for a 72-year-old hypertensive man with confirmed renal potassium wasting and primary aldosteronism. A computed tomography (CT) scan showed a left adrenal mass. Laboratory data suggested adrenal hyperplasia (2). Twenty-fourhour urine sodium ...References1. Sawka AM, Young WF, Thompson GB, Grant CS, Farley DR, Leibson C, . Primary aldosteronism: factors associated with normalization of blood pressure after surgery. Ann Intern Med. 2001;135:258-61. [PMID: 11511140] LinkGoogle Scholar2. Young WF, Hogan MJ, Klee GG, Grant CS, van Heerden JA. Primary aldosteronism: diagnosis and treatment. Mayo Clin Proc. 1990;65:96-110. [PMID: 2404167] CrossrefMedlineGoogle Scholar3. Weinberger MH, Grim CE, Hollifield JW, Kem DC, Ganguly A, Kramer NJ, . Primary aldosteronism: diagnosis, localization, and treatment. Ann Intern Med. 1979;90:386-95. [PMID: 218482] LinkGoogle Scholar4. Blumenfeld JD, Sealey JE, Schlussel Y, Vaughan ED, Sos TA, Atlas SA, . Diagnosis and treatment of primary hyperaldosteronism. Ann Intern Med. 1994;121:877-85. [PMID: 7978702] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Binghamton, NY 13903 (Martinez) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrimary Aldosteronism: Factors Associated with Normalization of Blood Pressure after Surgery Anna M. Sawka , William F. Young Jr. , Geoffrey B. Thompson , Clive S. Grant , David R. Farley , Cynthia Leibson , and Jon A. van Heerden Adrenalectomy for Primary Aldosteronism William F. Young Jr , Anna M. Sawka , and Jon A. van Heerden Metrics Cited ByA short review of primary aldosteronism in a question and answer fashion 21 January 2003Volume 138, Issue 2Page: 157-158KeywordsAdenomasAdrenalectomyAldosteroneAlgorithmsAntihypertensive drug therapyComputed axial tomographyCortisolPotassiumResearch laboratoriesUrine ePublished: 21 January 2003 Issue Published: 21 January 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Re: Nicolòmaria Buffi, Henk Van Der Poel, Giorgio Guazzoni, Alexander Mottrie, on behalf of the Junior European Association of Urology (EAU) Robotic Urology Section with the collaboration of the EAU Young Academic Urologists Robotic Section. Methods and Priorities of Robotic Surgery Training Program. Eur Urol 2014;65:1–2
Authors: Jacques Hubert, Richard M. Satava
Journal: European Urology (2014)
Reuse of Dialysis Coils
Authors: Martin S. Neff
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The possibility of reusing coils with 27% saline was reported by Bilinsky and Morris (<b>218</b>:1806-1808, 1971). We had previously had a fair degree of success reusing coils that were refrigerated between use and storage only with normal saline. Although problems were infrequent, significant episodes of sepsis caused us to abandon this procedure. Over a two-month period, we reused coils in four patients. Dialysance of urea and creatinine was stable with up to eight reuses, and we had no problem eliminating the hypertonic saline from the coil. However, one patient developed<i>Klebsiella</i>sepsis and the coil effluent collected prior to that dialysis subsequently yielded<i>Klebsiella</i>organisms; a second patient developed<i>Staphylococcus</i>sepsis but the coil effluent collected prior to dialysis was sterile. These episodes suggested that we should take a second look at the bacteriologic aspects of this procedure. We added 1 cc of bacterial innocula to
Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis
Authors: Tomasz I. Michalak, Ingrid U. Pardoe, Carla S. Coffin, Norma D. Churchill, Dion S. Freake, Paula Smith, Colleen L. Trelegan
Journal: Hepatology (1999)

Traces of hepatitis B virus (HBV) genome can persist for years following recovery from hepatitis B. To determine overall duration, molecular characteristics, and pathological implications of this serologically undetectable form of hepadnaviral carriage, we have analyzed the expression of transcriptionally active virus genomes, their infectivity, and examined liver alterations during the natural lifespan of woodchucks convalescent from acute infection with HBV– related woodchuck hepatitis virus (WHV). In this study, we document lifelong persistence of scanty amounts of replicating virus both in the liver and lymphatic system after spontaneous resolution of an episode of experimental hepadnaviral hepatitis. Antibodies to virus nucleocapsid (core) were found to be the most reliable immunovirological marker coexisting with occult infection. In the majority of convalescent woodchucks, serial liver biopsies showed protracted minimal to mild necroinflammation with periods of normal morphology; however, hepatocellular carcinoma (HCC) ultimately developed in 2 of 9 animals studied. Inocula derived from lymphoid cells of convalescent animals induced classical acute hepatitis in virus–naive woodchucks that progressed to chronic hepatitis and HCC in 1 of the animals, demonstrating infectivity and pathogenic competence of the carried virus. Our results reveal that low levels of infectious WHV and residual hepatic inflammation usually continue for life after resolution of hepatitis and that this recovery does not avert HCC development. They also demonstrate that, in addition to the liver, the lymphatic system is the site of the occult lifelong maintenance of replicating hepadnavirus.
Dialysis in Scleroderma
Authors: M. ROBSON
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 June 1978Dialysis in SclerodermaM. ROBSON, M.D., M.R.C.P.(L), O.G. OREOPOULOS, M.D.PH.D., F.R.C.P.(C)M. ROBSON, M.D., M.R.C.P.(L)Search for more papers by this author, O.G. OREOPOULOS, M.D.PH.D., F.R.C.P.(C)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-6-843 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Patients with scleroderma have been reported to have reduced urea and creatinine peritoneal clearances below those of patients with uncomplicated chronic renal failure (1). Attempts have been made to increase the reduced clearances by use of intraperitoneal vasodilators (2). Since this knowledge of reduced clearances in scleroderma may deter nephrologists from considering such patients for peritoneal dialysis, we thought it appropriate to publish our own findings in two patients with scleroderma undergoing peritoneal dialysis. Both patients were women, aged 47 and 54 years, had been dialyzed for 9 and 10 months, respectively, and were virtually anuric. Both...References1. NOLPHSTOLTZMAHER KMJ: Altered peritoneal permeability in patients with systemic vasculitis. Ann Intern Med 75:753-755, 1971 LinkGoogle Scholar2. BROWNAHEARNNOLPH SDK: Reduced peritoneal clearances in scleroderma increased by intraperitoneal isoproterenol. Ann Intern Med 78:891-894, 1973 LinkGoogle Scholar3. ROBSONOREOPOULOSIZATTOGILVIERAPOPORTDEVEBER MDSRAG: The influence of exchange volume and dialysate flow rate on solute clearance in peritoneal dialysis (abstract). American Society of Nephrology, 1977 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto Western Hospital Toronto, ON M5T 2S8 Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByScleroderma renal crisis: a review for emergency physiciansThe Physiology of Peritoneal Solute, Water, and Lymphatic TransportThe physiology of peritoneal solute transport and ultrafiltrationRupture spontanée de l'œsophage (syndrome de Boerhaave) chez une patiente sclérodermique traitée par dialyse péritonéale continue ambulatoirePeritoneal physiology-transport of solutesPractical Use of Peritoneal Dialysis 1 June 1978Volume 88, Issue 6Page: 843-843KeywordsCreatinineMedical dialysisPeritoneal dialysisRenal failureSclerodermaUreaVasodilators Issue Published: 1 June 1978 PDF DownloadLoading ...
Effects of the Gonadotropin-Releasing Hormone Antagonist Ganirelix on Normal Micturition and Prostaglandin E2–Induced Detrusor Overactivity in Conscious Female Rats
Authors: Andrea Russo, Fabio Castiglione, Andrea Salonia, Fabio Benigni, Patrizio Rigatti, Francesco Montorsi, Karl-Erik Andersson, Petter Hedlund
Journal: European Urology (2010)
Confession of a climate criminal
Authors: Ian Roberts
Journal: BMJ (2005)

Dear editor—I have just received this letter from a friend. It has serious implications for doctors and I think your readers would be interested in it.

Yours faithfully, Ian Roberts

Dear Ian—next week I am going to turn myself in. I have been on the run for years, flying in the face of reason, but it is just too exhausting. The charges against me include crimes against the planet and two counts of theft. But if I go down for this the medical profession is coming with me. They are saying I am a climate criminal and that for the past five years I have consumed unsustainably large amounts of air travel, pumping into the atmosphere tonnes of carbon dioxide that will continue to warm the planet for more than a century. In the past year I have flown to conferences in Auckland, Tokyo, Milan, and Rome. The charges are serious. According to a report by the World Health …
Review: Remote patient monitoring of patients with heart failure reduces mortality and heart failure admissions
Authors: Bertram Pitt
Journal: Annals of Internal Medicine (2010)

ACP Journal Club20 April 2010Review: Remote patient monitoring of patients with heart failure reduces mortality and heart failure admissionsBertram Pitt, MDBertram Pitt, MDUniversity of Michigan School of Medicine, Ann Arbor, Michigan, USA (B.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-8-201004200-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationKlersy C, De Silvestri A, Gabutti G, Regoli F, Auricchio A. A meta-analysis of remote monitoring of heart failure patients. J Am Coll Cardiol. 2009;54:1683-94. https://pubmed.ncbi.nlm.nih.gov/19850208Clinical Impact RatingsHospitalists: Cardiology: Reference1 Pitt B, Zannad F, Gheorghiade M, et al. Transatlantic similarities and differences in major natural history endpoints of heart failure after acute myocardial infarction: a propensity-matched study of the EPHESUS trial. Int J Cardiol. 2009 Apr 14 (Epub ahead of print). [PMID: 19371959] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Michigan School of Medicine, Ann Arbor, Michigan, USA (B.P.)This article was published at Annals.org on 6 April 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMale gender, diabetes, COPD, anemia, and creatinine clearance < 30 mL/min predicted hospitalization after heart failure diagnosis Bertram Pitt Metrics 20 April 2010Volume 152, Issue 8Page: JC4-3KeywordsCohort studiesHeart failureHospitalizationsLibrariesLongitudinal studiesMedical risk factorsMortalityNumber needed to treatObesityPatients ePublished: 20 April 2010 Issue Published: 20 April 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...