tbuckley/cabot-search huggingface dataset:
Measurement of Pleural Pressure during Therapeutic Thoracentesis
Authors: VICTORIA VILLENA, ANGEL LÓPEZ-ENCUENTRA, FRANCISCO POZO, ALICIA DE-PABLO, PEDRO MARTÍN-ESCRIBANO
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The aim of therapeutic thoracentesis (TT) is to aspirate as much pleural fluid as possible. Monitoring pleural pressure (PlP) during TT has been proposed to avoid the adverse effects due to an unintended sharp drop in PlP. The objectives of this study are to ascertain the diagnostic value of the PlP measurement, to find a predictive variable of the amount of fluid that can be removed, to obtain insight into the characteristics of the PlP curve and pleural elastance (PE) during TT, and to describe the complications of TT. Sixty-one unselected patients were studied. Only the four patients with suspected trapped lung had an initial PlP lower than -4 cm H(2)O and a PE higher than 33 cm H(2)O/L. There was a weak correlation (r = 0.52) between PE during the first 0.5 L aspirated and the total amount of fluid aspirated. Partial PE values were 10, 7.5, and 14 cm H(2)O/L at the early, intermediate, and late phases of TT. No complications were found except for nine pneumothoraces. In conclusion, the technique was clinically helpful because large amounts of pleural fluid could be aspirated with few and mild complications, and because it allows clinicians to support the preliminary diagnosis of trapped lung. None of the studied variables was found to predict the suitability of aspirating more than 1.5 L. Rather than being monotonically descendent, the PlP curve shows a three-part line with the deepest slopes at the first and last phases of the thoracentesis.
92 THE HEPATIC INFLAMMATORY MICROENVIRONMENT INDUCES ENDOTOXIN TOLERANT MONOCYTES IN ACETAMINOPHEN-INDUCED LIVER FAILURE
Authors: C.G. Antoniades, V. Zingarelli, L. Possamai, R. Mitry, W. Bernal, G. Auzinger, N. Heaton, A. Quaglia, Y. Ma, D. Vergani, J. Wendon, M. Thursz
Journal: Journal of Hepatology (2012)
A Pooled Analysis of Multicenter Cohort Studies of 123I-mIBG Imaging of Sympathetic Innervation for Assessment of Long-Term Prognosis in Heart Failure
Authors: Tomoaki Nakata, Kenichi Nakajima, Shohei Yamashina, Takahisa Yamada, Mitsuru Momose, Shu Kasama, Toshiki Matsui, Shinro Matsuo, Mark I. Travin, Arnold F. Jacobson
Journal: JACC. Cardiovascular imaging (2013)
CD30 and the NPM‐ALK fusion protein (p80) are differentially expressed between peripheral blood and bone marrow in primary small cell variant of anaplastic large cell lymphoma
Authors: Norihiro Awaya, Shigehisa Mori, Hitoshi Takeuchi, Shigeo Mori, Yasuo Sugano, Tamihiro Kamata, Tsutomu Takeuchi, Toru Abe
Journal: American Journal of Hematology (2002)

Abstract The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPM‐ALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cell variant is prone to have a leukemic presentation. Although the small cell variant has been recognized as a subtype of ALCL, the clinical properties of this subtype, especially the immunophenotype of lymphoma cells in peripheral blood, have not yet been fully described. This report shows that neither CD30 nor p80 is detected by immunostaining in the predominant small cell malignant clone and also in large lymphoma cells in peripheral blood, while large cells and occasionally observed small cells in bone marrow were found to be positive for CD30 and p80. Our findings suggest that differential expression of CD30 and p80 between peripheral blood and bone marrow lymphoma cells is a property of the small cell variant of ALCL. Am. J. Hematol. 69: 200–204, 2002. © 2002 Wiley‐Liss, Inc.
Abstract 3328: Targeted inactivation of EZH2 by CDF inhibits pancreatic tumor growth mediated by re-expression of lost miRNAs in tumors
Authors: Bin Bao, Shadan Ali, Sanjeev Banerjee, Farah Logna, Asfar Azmi, Dejuan Kong, Aamir Ahmad, Yiwei Li, Subhash Padhye, Hazlul H. Sarkar
Journal: Cancer Research (2012)

Abstract EZH2 plays a critical role in the regulation of cell survival, proliferation and cancer stem cell (CSC) function, contributing to tumor aggressiveness. Increased expression of EZH2 has been found in human pancreatic cancer (PC); however, the mechanism(s) by which EZH2 mediates its biological effects is not known, and there is no avenue for inactivation of EZH2. In this study, we examined the effect of CDF, a novel Curcumin analogue, on tumor cell growth in vitro and in vivo and assessed whether the effect of CDF is due to inactivation of EZH2 and CSC function mediated by deregulation of microRNAs (miRNAs). We found that CDF decreased cell survival, clonogenicity, formation of pancreatospheres, cell migration and invasion, and attenuated CSC function in human PC cells, which was associated with inactivation of EZH2 expression and NF-κB activity, and increased expression of miRNAs such as let-7a, b, c, d, miR-26a, miR-101, miR-146a, and miR-200b, c. Further mechanistic studies showed that the re-expression of miR-101 led to decreased expression of EZH2 and EpCAM. Moreover, CDF inhibited tumor growth in a mouse orthotopic model of PC, which was associated with decreased expression of EZH2, Notch-1, CD44, EpCAM and Nanog, and increased expression of let-7, miR-26a and miR-101 in tumor remnant. From these results, we conclude that the inhibition of tumor growth and tumor cell aggressiveness by CDF is in part due to down-regulation of EZH2, which was mediated by up-regulation of specific miRNAs, suggesting that CDF could be useful for the prevention of tumor progression and/or treatment of PC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3328. doi:1538-7445.AM2012-3328
IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B
Authors: Pietro Lampertico, Mauro Viganò, Cristina Cheroni, Floriana Facchetti, Federica Invernizzi, Vincenza Valveri, Roberta Soffredini, Sergio Abrignani, Raffaele De Francesco, Massimo Colombo
Journal: Hepatology (2012)

Interleukin (IL)28B polymorphisms have been associated with interferon (IFN)-induced viral clearance in patients with chronic hepatitis C. Whether this is also true for patients with the difficult-to-cure hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) is unknown. One hundred and one HBeAg-negative patients (92% genotype D) with compensated CHB (84% males, 46 years; hepatitis B virus [HBV] DNA: 6.0 log cp/mL; alanine aminotransferase [ALT]: 136 IU/L; 42% with cirrhosis) were followed up for a median of 11 years (range, 1-17) after a median of 23 months (range, 10-48) of either standard or pegylated (Peg)-IFN-alpha therapy. A post-treatment response was defined as hepatitis B surface antigen (HBsAg) clearance with or without antibody to hepatitis B surface antigen (anti-HBs) seroconversion. The rs12979860 (C>T) genotype in the IL28B locus was assessed in serum samples by using Custom TaqMan SNP Genotyping Assays (Applied Biosystems, Carlsbad, CA). During a median of 11 years of post-treatment follow-up, 21 patients (21%) cleared serum HBsAg, including 15 who developed>10 IU/mL of anti-HBs titers. Forty-eight patients (47%) had CC genotype, 42 (42%) had CT, and 11 (11%) had TT, with the allelic frequency being 68% for C allele and 32% for T allele. The rate of serum HBsAg clearance was 29% (n=14) in CC compared to 13% (n=7) in non-CC, genotype carriers (P=0.039). Baseline HBV DNA levels<6 log cp/mL (odds ratio [OR], 11.9; 95% confidence interval [CI]: 2.8-50.6; P=0.001), ALT levels>136 IU/L (OR, 6.5; 95% CI: 1.8-22.5; P=0.003), duration of IFN (OR, 1.16; 95% CI: 1.02-1.31; P=0.021), and genotype CC (OR, 3.9; 95% CI: 1.1-13.2; P=0.025) independently predicted HBsAg clearance.IL28B polymorphism is an additional predictor of off-therapy IFN-related HBsAg seroclearance to be used in the pretreatment stratification of HBeAg-negative patients chronically infected by genotype D of HBV.
Significance of variations in blood: breath partition coefficient of alcohol.
Authors: T A Alobaidi, D W Hill, J P Payne
Journal: BMJ (1976)

A helium-neon laser was used to measure the alcohol content of breath from six volunteers at regular intervals over up to four hours. The corresponding blood values were calculated with a blood : breath partition coefficient of 2100. When these values were compared with those obtained by direct measurement it was obvious that substantial variations occurred from one person to another in the derived values and that even in the same person the use of the partition coefficient of 2100 led to significant differences between the direct and derived values for blood, and these differences changed with time. Thus the assertion that a constant partition coefficient of 2100 exists between alcohol in blood and that in breath is not supported by the evidence. Accordingly the use of such a partition coefficient to derive blood alcohol values for law enforcement is not justified.
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
Authors: Gudmar Thorleifsson, G Bragi Walters, Alex W Hewitt, Gisli Masson, Agnar Helgason, Andrew DeWan, Asgeir Sigurdsson, Adalbjorg Jonasdottir, Sigurjon A Gudjonsson, Kristinn P Magnusson, Hreinn Stefansson, Dennis S C Lam, Pancy O S Tam, Gudrun J Gudmundsdottir, Laura Southgate, Kathryn P Burdon, Maria Soffia Gottfredsdottir, Micheala A Aldred, Paul Mitchell, David St Clair, David A Collier, Nelson Tang, Orn Sveinsson, Stuart Macgregor, Nicholas G Martin, Angela J Cree, Jane Gibson, Alex MacLeod, Aby Jacob, Sarah Ennis, Terri L Young, Juliana C N Chan, Wojciech S S Karwatowski, Christopher J Hammond, Kristjan Thordarson, Mingzhi Zhang, Claes Wadelius, Andrew J Lotery, Richard C Trembath, Chi Pui Pang, Josephine Hoh, Jamie E Craig, Augustine Kong, David A Mackey, Fridbert Jonasson, Unnur Thorsteinsdottir, Kari Stefansson
Journal: Nature Genetics (2010)
Bacterial Endocarditis: Failure with Clindamycin
Authors: IAN L. GARRIQUES
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 November 1973Bacterial Endocarditis: Failure with ClindamycinIAN L. GARRIQUES, M.D., RICHARD J. DUMA, M.D.IAN L. GARRIQUES, M.D.Search for more papers by this author, RICHARD J. DUMA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-756_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Menda and Gorbach (Ann Intern Med 78:25-32, 1973), in describing their experience with 23 cases of bacterial endocarditis, mention six patients treated with clindamycin, five of whom were infected with Staphylococcus aureus and one with Streptococcus viridans. One patient with S. aureus infection failed to respond and was treated subsequently with cephalothin. Elmore and his associates, in a follow-up letter (78:779-780, 1973), described a case of S. aureus endocarditis, that was successfully treated with clindamycin but complicated by "clindamycin hepatotoxicity."Less the readers be inclined to accept clindamycin as a suitable alternate to the penicillins in treating... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Immunology and Infectious Diseases Medical College of Virginia. Virginia Commonwealth University Richmond, Virginia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIntramuscular clindamycin for therapy of infective endocarditis 1 November 1973Volume 79, Issue 5Page: 756-757KeywordsClindamycinEndocarditisPenicillinStaphylococcal infectionStaphylococcus aureusStreptococcal infectionsStreptococcus Issue Published: 1 November 1973 PDF DownloadLoading ...
Chloroplast DNA Inversion Polymorphism in Populations of Abies and Tsuga
Authors: Yoshihiko Tsumura, Yoshihisa Suyama, Kensuke Yoshimura
Journal: Molecular Biology and Evolution (2000)

Polymorphism for a 42-kb chloroplast DNA inversion was detected in five species of Abies and two species of Tsuga based on a sample of 1,281 individuals and both Southern hybridization and polymerase chain reaction (PCR) analyses. Two haplotypes were observed in all populations and species. The 42-kb inversion is associated with a short inverted repeat that includes trnS, psaM, and trnG. The frequencies of the two haplotypes within species were very similar among the five species of Abies. This polymorphism has been maintained within populations and species in both Abies and Tsuga, probably because the mutation rate of the inversion is high. Haplotype frequencies had no geographical tendencies for any species except Abies mariesii, in which haplotype frequencies varied clinally, possibly as a result of rapid dissemination after the most recent glacial period and random genetic drift.
Neutrophil chemotaxis in juvenile chronic arthritis.
Authors: P H Trung, A M Prieur, C Griscelli
Journal: Annals of the Rheumatic Diseases (1980)

The leucocyte infiltration observed in histological lesions from patients with juvenile chronic arthritis (JCA) suggests the possibility of an abnormal leucochemotaxis. A group of 21 patients with JCA which fulfilled the Eular criteria (Oslo Symposium 77) were investigated with a paired group of 21 children. The chemotactic assay used was a microscopical direct observation technique. The chemotaxis of the patient9s leucocytes was in the normal range, as was the chemotactic activity of their serum. However, their serum had an enhancing effect on the chemotaxis of normal leucocytes. An attempt to characterise this chemotactic enhancing factor was undertaken. It was not dialysable, heat stable, destroyed at 80 degrees C, nor precipitated by ammonium sulphate at 45%; it could be migrated on PAGE with albumin, and, by precipitation with a goat antihuman albumin antiserum, seemed to be bound to the albumin fraction. The function of this factor in the regulation of the inflammatory process is discussed.
Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera.
Authors: M G Roncarolo, H Yssel, J L Touraine, H Betuel, J E De Vries, H Spits
Journal: The Journal of Experimental Medicine (1988)

T cell clones of donor origin that specifically react with recipient cells were obtained from a SCID patient successfully reconstituted by allogeneic fetal liver and thymus transplantation performed 10 yr ago. The majority of these clones displayed both cytotoxic and proliferative responses towards PBL and an EBV-transformed B cell line derived from the patient. In addition, these T cell clones had proliferative and cytotoxic responses towards the parental PBL, EBV cell lines, and PHA blasts. Blocking studies with anti-class I and anti-class II HLA mAbs indicated that the activity of the CD4+ T cell clones was specifically directed against class II HLA antigens of the recipient. On the other hand, the cytotoxic and proliferative responses of the CD8+ T cell clones were specific for class I HLA antigens which are ubiquitously expressed on the recipient cells. Thus, the establishment of transplantation tolerance observed in this stable human chimera is not due to the elimination of host-reactive T cells from the repertoire and suggests the presence of a peripheral autoregulatory suppressor mechanism.
The Essentials of Pædiatric Surgery
Authors: A. P. Hovnanian
Journal: JAMA (1962)

The authors state in the preface that their aim is to be helpful to the senior student and at the same time useful to the D.C.H. candidates, surgeons, and the general practitioners. They have accomplished this fully. This book is highly commendable for its lucid clarity in the handling of the surgical disease entities in the pediatric age group. The discussions are brief, to the point, nonrepetitious, and presented with thought. The reference list after every chapter is modest, but well chosen and easily available in any medical library. The book is studded with very communicative diagrams, pictures and colored plates. This treatise should be found in the library of the persons for whom it is intended and will interest any surgeon who plans to write "Essentials" in the future.
Abstract 5518: BPM 31510 exposure alters fluidity and molecular organization of cancer cell membranes, influencing signaling and cell fate decisions
Authors: Michael Kiebish, Sumit Garg, Vivek Vishnudas, Fei Gao, Min Du, Sirisha Dhavala, Katerina Krumova, Leonardo Rodriguez, Shen Luan, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Niven R. Narain
Journal: Cancer Research (2014)

Abstract The dynamic state of membranes impinges on pathways critical for cancer cell survival or death while influencing cancer cell metabolism. Here in, we investigated the effects of BPM 31510, a proprietary ubidecarenone formulation, on temporal alterations in membrane adaptation, proteomic and lipidomic reorganization, initiation of key apoptotic signaling pathways, bioenergetic integration, as well as cell fate decision processes in in vitro models of representative cancers. This approach was harvested to decipher a systems wide understanding of BPM 31510's effects on various human cancer cell lines (prostate, pancreatic, skin, breast and ovarian ) as well as effect on representative control cell lines. BPM 31510 exposure in vitro resulted in a stochastic shift in membrane fluidity in various cancer cell lines. Global untargeted shotgun lipidomics and proteomics revealed selective lipidomic and protein shifts in a temporal manner across various cancer lines resultant from BPM 31510 exposure. Berg informatics suite comprising of Bayesian artificial intelligence systems engineering framework linked specific pivot lipid molecular species and proteins to the action of BPM 31510 based on dynamic time course experiments and biological endpoints including cellular metabolism and cell fate (apoptosis) across cancer cell lines. Thus, the data presented within demonstrate that BPM 31510 affects the cancer cell biomembrane structure, membrane lipid reorganization with potential to influence intracellular signaling, cell fate decision making processes and metabolism. The systems approach described within provides novel insight into the pleiotropic effects of BPM 31510 on cancer cells. Citation Format: Michael Kiebish, Sumit Garg, Vivek Vishnudas, Fei Gao, Min Du, Sirisha Dhavala, Katerina Krumova, Leonardo Rodriguez, Shen Luan, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Niven R. Narain. BPM 31510 exposure alters fluidity and molecular organization of cancer cell membranes, influencing signaling and cell fate decisions. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5518. doi:10.1158/1538-7445.AM2014-5518
Association of Blood Pressure With Fibrinolytic Potential in the Framingham Offspring Population
Authors: Kim A. Poli, Geoffrey H. Tofler, Martin G. Larson, Jane C. Evans, Patrice A. Sutherland, Izabella Lipinska, Murray A. Mittleman, James E. Muller, Ralph B. D’Agostino, Peter W. F. Wilson, Daniel Levy
Journal: Circulation (2000)

Background —Hypertension is an established risk factor for acute coronary events. Because fibrinolytic and hemostatic factors are also associated with cardiovascular disease, we examined the relations of systolic and diastolic blood pressures (SBP and DBP) to levels of plasminogen activator inhibitor antigen, tissue plasminogen activator antigen, fibrinogen, factor VII, von Willebrand factor, fibrinogen, and plasma viscosity in subjects of the Framingham Offspring Study. Methods and Results —We studied 1193 men and 1459 women after the exclusion of subjects with known cardiovascular disease and those receiving anticoagulant or antihypertensive therapy. Linear regression models were used to evaluate SBP and DBP as predictors of fibrinolytic and hemostatic factor levels in separate sex models, with adjustment for age, body mass index, smoking, diabetes, total cholesterol, HDL, triglycerides, alcohol intake, and estrogen use (in women). In both sexes, levels of plasminogen activator inhibitor and tissue plasminogen activator antigen were positively related to SBP and DBP ( P &lt;0.001). Plasma viscosity was positively related to SBP ( P =0.008) and DBP ( P =0.001) in women only. There was no association between SBP or DBP and fibrinogen, factor VII, or von Willebrand factor in either sex. Conclusions —These data suggest that impaired fibrinolysis may play an important role in the pathogenesis of cardiovascular disease in hypertensive patients.
The Effect of Digitoxin on Sodium Excretion, Creatinine Clearance and Apparent Cardiac Output
Authors: M. J. GREVE, E. E. EDDLEMAN, K. WILLIS, S. EISENBERG, T. R. HARRISON
Journal: Circulation (1951)

During the initial phase of decline in cardiac output following the administration of digitoxin to normal subjects, sodium excretion did not decline. Several days later, as cardiac output rose toward the normal level, sodium output decreased in most subjects. The possible implication of these re sults in relation to the regulation of sodium excretion is discussed.
Immediate contact allergy from hydrolyzed wheat in a cosmetic cream
Authors: E. Varjonen, L. Petman, S. Mäkinen‐Kiljunen
Journal: Allergy (2000)

Immediate contact allergy to cosmetics seems to be rare, since only a few case reports on it have been published. We report on a case of IgE‐mediated allergic contact urticaria caused by hydrolyzed wheat in a body cream.
How often is genital yeast infection sexually transmitted?
Authors: R N Thin, M Leighton, M J Dixon
Journal: BMJ (1977)

We analysed data from a computer-based bank of clinical records of patients seen in a clinic for sexually transmitted diseases over a three-year period to investigate the association between genital yeast infections and sexually transmitted diseases (STDs). We classified STDs as primary and secondary syphilis; gonorrhoea; lymphogranuloma venereum; trichomoniasis; scabies; pediculosis; genital herpes; warts; and molluscum contagiosum. Of a total of 2984 disease episodes among women, 1054 (35-3%) included yeast infections, whereas only 382 (6-9%) of 5501 episodes in heterosexual men were associated with yeast infections, We found a significant association between yeast infection and STD and non-specific genital infection (non-specific urethritis (NSU) and procitis in men, and female contacts of men with NSU), which suggested that yeast infection was sexually acquired in 414 out of 1054 disease episodes in women (39%) and 110 out of 382 episodes in heterosexual men (29%). We conclude that sexually active patients with genital yeast infections should be screened for other STDs particularly non-specific genital infection.
Drug company pays for campaign for chicken pox vaccination
Authors: J. Siegel-Itzkovich
Journal: BMJ (2000)

Advertisements have begun to appear on Israeli television channels and radio stations and in the newspapers urging parents—at their own expense—to get their children vaccinated against chicken pox.

The campaign, organised by the Israel Paediatrics Association and the Israel Family Physicians Association, is financed by SmithKline Beecham, which manufactures Varilrix—the sole brand of varicella zoster vaccine to be approved so far by the health ministry.

The campaign was initiated and launched without the organisers having consulted or even informed the health ministry, which fears it will be pressured …