tbuckley/cabot-search huggingface dataset:
Cholescintigraphy in the Evaluation of Jaundice-Reply
Authors: Barbara B. Frank
Journal: JAMA (1990)

<h3>In Reply.—</h3> The purpose of practice guidelines is to advise clinicians of the most useful, safe, and cost-effective approach to clinical problems. Such advice should be based on the best evidence available in the literature and, whenever possible, on controlled clinical trials. Dr Morayati takes issue with our guidelines on the clinical evaluation of jaundice in their failure to include cholescintigraphy as a diagnostic modality in patients with jaundice and refers to the reports of Weissmann et al<sup>1</sup>and Pauwels et al<sup>2</sup>to support his viewpoint. The article by Weissmann et al provides a lucid but uncontrolled description of cholescintigraphic findings that are suggestive of obstruction in postoperative patients, with no description of methods, no indication that interpretation of the scans was blinded, and no attempt to compare cholescintigraphy with other diagnostic modalities.<sup>1</sup>In the study by Pauwels et al, scans were interpreted by two different observers
A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells
Authors: Samantha Solito, Erika Falisi, Claudia Marcela Diaz-Montero, Andrea Doni, Laura Pinton, Antonio Rosato, Samuela Francescato, Giuseppe Basso, Paola Zanovello, Georgiana Onicescu, Elizabeth Garrett-Mayer, Alberto J. Montero, Vincenzo Bronte, Susanna Mandruzzato
Journal: Blood (2011)
Revision to the American College of Physicians' Ethics Manual
Authors: Frederick E. Turton, Lois Snyder
Journal: Annals of Internal Medicine (2008)

Letters3 June 2008Revision to the American College of Physicians' Ethics ManualFrederick E. Turton, MD, MBA and Lois Snyder, JDFrederick E. Turton, MD, MBAFrom American College of Physicians, Philadelphia, PA 19106.Search for more papers by this author and Lois Snyder, JDFrom American College of Physicians, Philadelphia, PA 19106.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-11-200806030-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The American College of Physicians (ACP) has been active in issues concerning health and human rights for many years. More recently, the College has focused attention on the humane treatment of prisoners and detainees.In October, the College's Board of Regents approved a revision to update the ACP Ethics Manual (1) as the next step in our policy development in this area. The revision was developed by the Ethics, Professionalism, and Human Rights Committee to specifically address physician participation in interrogation. The Committee believes that the general policy of the Ethics Manual needed to be updated in ...Reference1. Snyder L, Leffler C. Ethics and Human Rights Committee, American College of Physicians. Ethics manual: fifth edition. Ann Intern Med. 2005;142:560-82. [PMID: 15809467] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From American College of Physicians, Philadelphia, PA 19106.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEthics Manual Lois Snyder , Cathy Leffler , and Metrics Cited byThe analysis and resolution of ethical dilemmasAmerican College of Physicians Ethics Manual Sixth EditionLois Snyder, JD, for the American College of Physicians Ethics, Professionalism, and Human Rights Committee* 3 June 2008Volume 148, Issue 11Page: 887-888KeywordsConflicts of interestInformation technologyMedical conditions ePublished: 3 June 2008 Issue Published: 3 June 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Baseline Bleeding Risk and Arterial Access Site Practice in Relation to Procedural Outcomes After Percutaneous Coronary Intervention
Authors: Mamas A. Mamas, Simon G. Anderson, Matthew Carr, Karim Ratib, Iain Buchan, Alex Sirker, Douglas G. Fraser, David Hildick-Smith, Mark de Belder, Peter F. Ludman, James Nolan
Journal: Journal of the American College of Cardiology (2014)
Inflammatory myofibroblastic tumor: an unusual submucosal lesion of the stomach
Authors: Y. Lee, H. Wang, L. Shyung, C. Chang, M. Chen
Journal: Endoscopy (2011)

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal tumor that occurs preferentially in children and young adults. IMTs were considered arise as a result of a reactive inflammatory or post surgery process [1]. However, they are thought to have low-grade malignant potential, based on the recent molecular finding of rearrangement at chromosome band 2p23, the site of the anaplastic lymphoma kinase (ALK) gene in the tyrosine kinase locus [2]. They are most commonly found in the lung but may arise in extrapulmonary sites [3].
THE PURIFICATION OF PUBLIC WATER SUPPLIES.
Authors: GEORGE H. ROHE
Journal: JAMA (1896)

The most vitally important sanitary problem confronting American municipalities at the present day is, unquestionably, the supply of pure water for drinking and other domestic purposes. The wide-spread prevalence of typhoid fever may be practically looked upon as a measure of the pollution of the drinking water. Depending as this disease does almost entirely upon an infected water supply, the importance of having the latter of a pure quality is self-evident. In 1894, twenty-five of the principal cities of the United States had an average typhoid mortality of 39.6 per hundred thousand of population. Those cities which had the largest mortality from this disease were supplied by a highly suspicious quality of drinking water. It will be hardly necessary at the present day to insist upon the etiologic relation of infected water to typhoid fever. The numerous epidemics in this country and abroad, which have been studied with so much
Infectious Arthritis Complicating Neoplastic Disease
Authors: George W. Douglas, Robert H. Levin, Leon Sokoloff
Journal: New England Journal of Medicine (1964)

RHEUMATIC complaints are not infrequent in patients whose primary problem is leukemia or other neoplastic disease. Among the recognized causes of the musculoskeletal discomforts in these conditions are leukemic infiltration of para-articular1 and, less often, synovial2 tissues, occasionally secondary gout,3 dermatomyositis,4 hemarthrosis secondary to hemorrhagic diathesis,5 amyloidosis in multiple myeloma6 and hypertrophic osteoarthropathy.7 The obverse of the relation between rheumatic disease and neoplasia also occurs on rare occasions, as in the development of lymphomas in rheumatoid arthritis8 and Sjögren's syndrome,9 and of leukemia in patients irradiated for ankylosing spondylitis.10 The purpose of this paper is to call attention to infectious . . .
The Composition of Some So-called Synthetics and "Ethical" Nostrums.
Authors: S. Lewis Summers
Journal: JAMA (1904)

Philadelphia, April 20, 1904. <h3>To the Editor:</h3> —One of the noblest attributes of the character of an American is his desire for fair play; and one of the fundamental principles of American justice is that the accused party is considered innocent until proved guilty. The comments published in the issue of April 16, 1904, under the above heading, insomuch as they refer to products of our manufacture, are not in accordance with the facts. First, as to thermol, concerning which it is stated that this "wonderful new discovery is nothing but impure phenacetin." Would it not be more to the point to definitely state what that impurity is? and in what quantity? As to the explanation that "possibly traces of salicylic acid have been added to the product from time to time," that would lead one to think that salicylic acid had been added in a mechanical way merely for
Abstract 13026: Apixaban in Patients with Atrial Fibrillation and Prior Coronary Artery Disease: Insights from the ARISTOTLE Trial
Authors: Maria Cecilia Bahit, Renato D Lopes, Stephan H Hohnloser, Daniel Wojdyla, John H Alexander, Basil S Lewis, Philip Aylward, Freek W Verheugt, Matyas Keltai, Rafael Diaz, Puneet Mohan, Christopher B Granger, Lars Wallentin
Journal: Circulation (2012)
Abstract 4201: Role of adenomatous poliposis coli (APC) in cigarette smoke condensate-induced accumulation of apurinic/apyrimidinic lesions and enhanced transformation of normal breast epithelial cells
Authors: Harekrushna Panda, Aruna S. Jaiswal, C. Gary Gairola, Satya Narayan
Journal: Cancer Research (2011)

Abstract Active and passive smoking are major risk factors for cancer and have been implicated in the etiology of breast cancer. The mechanisms through which smoking promotes breast cancer are poorly understood. Our previous studies have shown that cigarette smoke condensate (CSC), a surrogate for cigarette smoke, induces transformation of normal human breast epithelial (MCF10A) cells in culture. We have described the involvement of a multifunctional protein, adenomatous polyposis coli (APC), in the CSC-induced transformation of MCF10A cells through the interaction with DNA polymerase β and 5’-flap endonuclease 1 (Fen1), and thus, the blockade of the BER pathway. In the present study, we have examined the underlying mechanisms involved in CSC and Benzo[α]pyrene (B[α]P)-induced transformation of MCF10A cells in which APC was overexpressed or knocked down. Our results suggest a positive correlation between the increased levels of APC expression with the decreased BER activity and concomitant accumulation of apurinic/apyrimidinic (AP)-site lesions. If not repaired on time, the cytotoxic and mutagenic AP-site lesions ultimately lead to enhanced transformation of MCF10A cells. These studies suggest a possible mechanism by which active and/or passive cigarette smoking might be linked with breast carcinogenesis. This work was supported by Flight attendant Medical Research Institute, Miami, FL to SN. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4201. doi:10.1158/1538-7445.AM2011-4201
TCT-734 The Role of Right Sided Hemodynamic Parameters as Predictors of 30 Day Outcome After Transcatheter Aortic Valve Replacement: The Impact of Right Ventricular Stroke Work Index
Authors: Rajiv Tayal, Manjusha Anna, Cheng Chu, Martin Miguel I Amor, Geru Wu, Najam Wasty, Marc Cohen
Journal: Journal of the American College of Cardiology (2014)
Herpetiform pemphigus induced by penicillamine
Authors: R.A. MARSDEN, R.P.R. DAWBER, P.R. MILLARD, G. MOWAT
Journal: British Journal of Dermatology (1977)

A patient with arthritis is described who developed a dermatitis herpetiformis-like rash after 8 months of D-penicillamine therapy and which cleared soon after the drug was discontinued. The histopathological findings were compatible with a diagnosis of pemphigus, showing intra-epidermal vesicles and spongiosis but no acantholysis. Intercellular antibody was detected by indirect immunofluorescence at the onset of the eruption (titre 1 in 160) and also found in serum taken prior to penicillamine treatment (titre 1 in 20). It is now well known that D-penicillamine can induce pemphigus. The findings reported here suggest the possibility that the patient was predisposed to develop the eruption before the drug was given.
Fiberoptics: Morbidity and Cost
Authors: Bernard S. Bloom, Samuel Z. Goldhaber, Paul H. Sugarbaker, Nicholas E. O'Connor
Journal: New England Journal of Medicine (1973)

Technologic developments are extending the scope of surgery dramatically, as in coronary-artery bypass and organ transplantation. These developments have usually been associated with increased complexity and greater cost. The use of flexible fiberoptic instruments is an interesting exception so far as it permits simplification of diagnoses and treatments of gastrointestinal and other problems with reduced complications and costs for the patient.In this issue of the Journal, Wolff and Shinya have shown that the fiberoptic colonoscope can visualize, biopsy and usually remove all pedunculated and many sessile polyps from rectum to cecum, thus avoiding the complications and extended hospital . . .
Pulmonary physicians, intensive care medicine and Thorax: an evolving relationship
Authors: S Baudouin
Journal: Thorax (2003)

Intensive care medicine as a separate specialty will impact on the availability of services, training of pulmonary physicians, and the content of respiratory medicine journals such as Thorax. 

In the 1990s a series of well publicised cases, in which critically ill patients were moved large distances in order to gain access to intensive care facilities, led to the recognition that the provision of intensive care services in the UK was characterised by unacceptable variations in organisation and delivery, quantity, funding, and effectiveness. It was appreciated that the ad hoc development of the discipline of intensive care medicine—following its origins in the polio epidemics of the 1950s—was responsible in part for this unhappy state of affairs. However, it was also apparent that there had been years of relative underfunding of intensive care units (ICUs) in the UK compared with other developed societies. The provision of ICU beds in the UK has historically been one of the smallest in the industrialised world. Only 2.6% of hospital beds were designated for intensive care before 2001 compared with averages of 3.3% and 5–7% in Europe and North America, respectively.1 Furthermore, in the UK the practice of intensive care medicine was led principally by clinicians with anaesthesia as their base speciality, who were being asked increasingly to provide multiple services across numerous hospital departments ranging from pain relief to supporting day case, high throughput surgery. Many of these issues were recognised in the Audit Commission report of 1999.2

By the end of the last decade, many pressure groups and professional bodies within the medical and allied professions—most notably the Intensive Care Society—together with central government recognised that a new multidisciplinary approach to the delivery of critical care services across acute hospitals was desirable. Consequently, in April 1999 the Department of Health appointed a …
Statistics, Smoking, and Health-Reply
Authors: Richard J. Hickey
Journal: JAMA (1986)

In Reply—  Drs Wilke and Slade disapprove of my views that cigarette smoking is symptomatic of genetic deficiencies in one or more biogenic monoamine neurotransmitter hormones that nicotine tends to alleviate. Disapproval cannot reject an hypothesis. Causality is based on scientific evidence, not on opinion, popularity, authority, misused statistics, or ideology.  Epidemiology, as practiced by some nonepidemiologists, can be detrimental to the credibility of the discipline, and possibly to public health. Cause has been confused with symptom, and the fallacy of inferring causality from correlation has been found acceptable to some biomedical investigators and to some federal and private agencies.  For example, the 1964 Surgeon General's report on smoking and health 1 states: Statistical methods cannot establish proof of a causal relationship in a correlation. The causal significance... is a matter of judgment which goes beyond any statement of statistical probability. This procedure equates opinion with fact; it is therefore
Serological diagnosis of Helicobacter pylori--evaluation of four tests in the presence or absence of non-steroidal anti-inflammatory drugs.
Authors: A S Taha, J Reid, P Boothmann, C G Gemmell, F D Lee, R D Sturrock, R I Russell
Journal: Gut (1993)

The host9s humoral immune response to Helicobacter pylori has been used in the diagnosis of active infection with these organisms. Several commercial tests are available but there are few and unconfirmed reports of their efficacy. This study aimed to assess and compare the efficacy of the following H pylori serological tests in patients treated or not treated with non-steroidal anti-inflammatory drugs (NSAID): Pyloriset Latex, Helico-G, Biolab Malakit, and Bio-Rad GAP Test IgG. Venous blood was tested at random in 124 patients, 64 of whom had received NSAID and 60 who had not. H pylori IgG antibodies were detected by latex agglutination (Pyloriset), or by ELISA (the remaining tests). Endoscopic gastric antral biopsy specimens were also obtained for urease activity, culture, and histology. Detection of H pylori by at least two of these was considered as a true positive, and its absence in all biopsy specimens as a true negative. The sensitivity values in the presence (or absence) of NSAID were: Pyloriset Latex, 59 (60)%; Helico-G, 79 (74)%; Biolab Malakit, 85 (81)%; and Bio-Rad GAP Test IgG, 100 (95)%. The respective specificity values were: 50 (71)%, 47 (59)%, 50 (65)%, and 30 (29)%. The Bio-Rad GAP Test IgG has the highest sensitivity and the lowest specificity values regardless of NSAID intake. The sensitivity of the other tests, however, is less than that of the standard biopsy related tests and their specificity is even lower in chronic NSAID users.
Predictors of Long-Term Recurrent Vascular Events After Ischemic Stroke at Young Age
Authors: Alessandro Pezzini, Mario Grassi, Corrado Lodigiani, Rosalba Patella, Carlo Gandolfo, Andrea Zini, Maria Luisa DeLodovici, Maurizio Paciaroni, Massimo Del Sette, Antonella Toriello, Rossella Musolino, Rocco Salvatore Calabrò, Paolo Bovi, Alessandro Adami, Giorgio Silvestrelli, Maria Sessa, Anna Cavallini, Simona Marcheselli, Domenico Marco Bonifati, Nicoletta Checcarelli, Lucia Tancredi, Alberto Chiti, Elisabetta Del Zotto, Alessandra Spalloni, Alessia Giossi, Irene Volonghi, Paolo Costa, Giacomo Giacalone, Paola Ferrazzi, Loris Poli, Andrea Morotti, Maurizia Rasura, Anna Maria Simone, Massimo Gamba, Paolo Cerrato, Giuseppe Micieli, Maurizio Melis, Davide Massucco, Valeria De Giuli, Licia Iacoviello, Alessandro Padovani
Journal: Circulation (2014)

Background— Data on long-term risk and predictors of recurrent thrombotic events after ischemic stroke at a young age are limited. Methods and Results— We followed 1867 patients with first-ever ischemic stroke who were 18 to 45 years of age (mean age, 36.8±7.1 years; women, 49.0%), as part of the Italian Project on Stroke in Young Adults (IPSYS). Median follow-up was 40 months (25th to 75th percentile, 53). The primary end point was a composite of ischemic stroke, transient ischemic attack, myocardial infarction, or other arterial events. One hundred sixty-three patients had recurrent thrombotic events (average rate, 2.26 per 100 person-years at risk). At 10 years, cumulative risk was 14.7% (95% confidence interval, 12.2%–17.9%) for primary end point, 14.0% (95% confidence interval, 11.4%–17.1%) for brain ischemia, and 0.7% (95% confidence interval, 0.4%–1.3%) for myocardial infarction or other arterial events. Familial history of stroke, migraine with aura, circulating antiphospholipid antibodies, discontinuation of antiplatelet and antihypertensive medications, and any increase of 1 traditional vascular risk factor were independent predictors of the composite end point in multivariable Cox proportional hazards analysis. A point-scoring system for each variable was generated by their β-coefficients, and a predictive score (IPSYS score) was calculated as the sum of the weighted scores. The area under the receiver operating characteristic curve of the 0- to 5-year score was 0.66 (95% confidence interval, 0.61–0.71; mean, 10-fold internally cross-validated area under the receiver operating characteristic curve, 0.65). Conclusions— Among patients with ischemic stroke aged 18 to 45 years, the long-term risk of recurrent thrombotic events is associated with modifiable, age-specific risk factors. The IPSYS score may serve as a simple tool for risk estimation.
Pancreaticopleural Fistula Treated by Transpapillary Implantation of a Plastic Prosthesis
Authors: B. Griesshammer, M. Strobel
Journal: Endoscopy (1998)

See also: Pancreatic-Pleural Fistula Demonstrated by Endoscopic Retrograde CholangiopancreatographyEndoscopy 1996; 28(09): 784-784DOI: 10.1055/s-2007-1005609
Radionuclide Scrotal Imaging in Anaphylactoid Purpura
Authors: MOSHE M. MELLOUL, BEN ZION GARTY
Journal: Clinical Nuclear Medicine (1993)

Tc-99m pertechnetate radionuclide scrotal scanning was performed on nine hospitalized boys with anaphylactoid purpura and acute scrotal tenderness. Scrotal involvement in anaphylactoid purpura is generally a part of the basic pathological process (i.e., vasculitis). Sometimes testicular torsion could not be excluded by physical examination. Tc-99m radionuclide scan was proven to be a useful tool, enabling distinction between the two processes. In all the patients the scan showed increased flow to the scrotum, compatible with inflammation of the scrotal wall and normal testicular perfusion, ruling out testicular torsion. All the boys were treated conservatively, with rapid resolution of the scrotal symptoms.
Vitamin D receptor genotypes and bone mineral density
Authors: H. Kröger, A. Mahonen, S. Ryhänen, A-M. Turunen, E. Alhava, P. Mäenpää, Toshikatsu Matsuyama, Seiichi Ishii, Akifumi Tokita, Keijiro Yabuta, Shunji Yamamori, NigelA. Morrison, JohnA. Eisman, S.L. Ferrari, R. Rizzoli, T. Chevalley, J. Eisman, J-P. Bonjour
Journal: The Lancet (1995)
Characterization of poly(l-lactic acid) microspheres loaded with holmium acetylacetonate
Authors: J.F.W Nijsen, M.J van Steenbergen, H Kooijman, H Talsma, L.M.J Kroon-Batenburg, M van de Weert, P.P van Rijk, A de Witte, A.D van het Schip, W.E Hennink
Journal: Biomaterials (2001)
Cause of Death
Authors: Donald T. Reay
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The July 17, 1987, issue of<i>JAMA</i>contained an article by Kircher and Anderson<sup>1</sup>concerning the proper completion of the death certificate. The dissemination of this information is long overdue and the authors are to be commended. However, their choice of examples to illustrate accurate death certification in trauma victims would have been more causally specific if the authors had not included "automobile accident" and "slipped and fell in bathtub" in the cause of death section. In our view, the authors have mixed etiology and manner of death with the cause of death, which should reflect either a disease or injury. This could have been avoided with a more appropriate choice of proximate cause. The appropriate proximate cause in both of these instances is "blunt impact" or "blunt force" to the specified body area. The authors listed "automobile accident" and "slipped and fell in bathtub" as the
Kidney transplant pioneer John P. Merrill drowns
Authors: Phil Gunby
Journal: JAMA (1984)

John P. Merrill, MD, whose landmark 1956 report of human kidney transplantation is reprinted in this issue (pp 2566-2571), drowned April 4 in a dockside accident while vacationing in the Commonwealth of the Bahamas. He spent his entire career at Harvard Medical School, Boston, from which he graduated in 1942 and where he was emeritus professor of medicine, and at the Brigham and Women's Hospital, where he took part in the first successful kidney transplant surgery nearly 30 years ago and where after World War II, he helped to build an artificial kidney unit. During that war, as a (then) Army Air Corps major, he served as flight surgeon to the aircrew of the B-29 bomber<i>Enola Gay</i>, who dropped the first atomic bomb on (Hiroshima) Japan. After the war, he returned to his native New England (he was born in Hartford, Conn, in 1917; attended St George's School, Newport,