tbuckley/cabot-search huggingface dataset:
Molecular characterization and PCR diagnosis of Thailand deletion of α-globin gene cluster
Authors: Tsang-Ming Ko, Li-Hui Tseng, Chuan-Hong Kao, Yu-Wan Lin, Hsiao-Lin Hwa, Pi-Mei Hsu, Shue-Fun Li, Sou-Ming Chuang
Journal: American Journal of Hematology (1998)

Thailand deletion of ␣-Thalassemia (thal) 1 involves the 2-, 1-, ␣2-, ␣1-, and 1-globin genes.In Southeast Asians and Taiwanese, this mutation is the second most common long-segment deletion of two ␣-globin genes, after the Southeast Asian deletion.To define the Thailand deletion breakpoints, we used polymerase chain reaction (PCR) to amplify the normal-sequence DNA fragments across the breakpoints.The amplified products were sequenced directly or after cloning into pGem®-3Z or pCR®2.1 vectors.Comparison of the normal and mutant sequences revealed that the 5 breakpoint lies between nucleotides 1,269 and 1,290 upstream of the initiator codon adenine of the 2-globin gene, and the 3 breakpoint lies between nucleotides 29,387 and 29,408 downstream of it.A total of 30,677 nucleotides were deleted.Both breakpoints mentioned above lie within the Alu repetitive sequences and an extensive sequence homology is present around the two breakpoints.These findings suggest that homologous recombination is the mechanism by which the deletion occurs.Based on our data, we used three oligonucleotide primers to amplify the regions across the deletion and its corresponding normal sequence.The feasibility of PCR diagnosis was confirmed in 20 carriers with this deletion.Am.
The History of Medicine: An Annotated List of Key Reference Works
Authors: W. Bruce Fye
Journal: Annals of Internal Medicine (1993)

This annotated bibliography of reference works or “secondary sources” in the history of medicine was prepared to assist people interested in reading or writing about medical history. The list includes comprehensive bibliographies of primary sources (original printed works and manuscripts), secondary sources (historical or derivative works), general histories of medicine, and collected biographies of physicians and medical scientists.
Treatment of Takayasu's Arteritis
Authors: STEPHEN HALL
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986Treatment of Takayasu's ArteritisSTEPHEN HALL, F.R.A.C.P., GENE G. HUNDER, M.D.STEPHEN HALL, F.R.A.C.P.Search for more papers by this author, GENE G. HUNDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-288_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The prospective analysis by Shelhamer and colleagues (1) of 20 patients seen at the National Institute of Health is a valuable contribution to the study of Takayasu's arteritis. We have recently reported a similar, though retrospective, study of 32 patients seen at our institution (2).In Shelhamer and colleagues' study, patients were considered to have an unsatisfactory response to corticosteroid treatment if there was angiographic progression of arterial lesions. This criterion assumes that inflammation alone is the cause of arterial lesions and that inflammation must still be present if arterial lesions progress. While this may be true,...References1. SHELHAMERVOLKMANPARRILLOLAWLEYJOHNSTONFAUCI JDJTMA. Takayasu's arteritis and its therapy. Ann Intern Med. 1985;103:121-6. LinkGoogle Scholar2. HALLBARRLIESTANSONKAZMIERHUNDER SWJAFG. Takayasu arteritis: a study of 32 North American patients. Medicine (Baltimore). 1985;64:89-99. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEPHEN HALL, F.R.A.C.P.; GENE G. HUNDER, M.D.Affiliations: Mayo Medical School Rochester, MN 55905 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritisPulmonary arterial lesions in Takayasu arteritis: Relationship of inflammatory activity to scintigraphic findings and sequential changesMedical treatment of Takayasu arteritisPatientin mit Takayasu-Arteriitis und Protein C- sowie AT III-Mangel 1 February 1986Volume 104, Issue 2Page: 288-288KeywordsInflammationLesionsRetrospective studies ePublished: 1 December 2008 Issue Published: 1 February 1986 PDF downloadLoading ...
Malice, intention, patience, and resource
Authors: T. Dalrymple
Journal: BMJ (2011)

There was a time when doctors wrote their memoirs and the public bought them. Whether doctors were better writers in those days or the public had fewer amusements to choose from I cannot say; but Halliday Sutherland’s memoir, The Arches of the Years , published in 1933, was reprinted in Britain at least 34 times and was translated into eight European languages.

Sutherland (1882-1960) was an interesting figure. He spent most of his professional life working on the prevention of tuberculosis, and he wrote books on the subject. He made the first health education film in Britain. He became a firm Catholic and wrote pamphlets against artificial contraception. In 1923 he …
Subepidermal bullous dermatosis with IgA antibodies against 200- and 280-kDa epidermal antigens after initiation of ultraviolet B therapy for psoriasis
Authors: M. Kallel Sellami, F. Cherif, M. Zitouni, L. Laadhar, M. Mokni, K. Hajlaoui, A. Ben Osman Dhahri, S. Makni
Journal: British Journal of Dermatology (2005)

Journal Article Subepidermal bullous dermatosis with IgA antibodies against 200‐ and 280‐kDa epidermal antigens after initiation of ultraviolet B therapy for psoriasis Get access M. Kallel Sellami, M. Kallel Sellami Departments of Immunology and Dermatology, La Rabta Hospital, El Jabbari, 1007 Tunis, Tunisia E‐mail: maryam_kallel@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar F. Cherif, F. Cherif Departments of Immunology and Dermatology, La Rabta Hospital, El Jabbari, 1007 Tunis, Tunisia E‐mail: maryam_kallel@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar M. Zitouni, M. Zitouni Departments of Immunology and Dermatology, La Rabta Hospital, El Jabbari, 1007 Tunis, Tunisia E‐mail: maryam_kallel@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar L. Laadhar, L. Laadhar Departments of Immunology and Dermatology, La Rabta Hospital, El Jabbari, 1007 Tunis, Tunisia E‐mail: maryam_kallel@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar M. Mokni, M. Mokni Departments of Immunology and Dermatology, La Rabta Hospital, El Jabbari, 1007 Tunis, Tunisia E‐mail: maryam_kallel@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar K. Hajlaoui, K. Hajlaoui Departments of Immunology and Dermatology, La Rabta Hospital, El Jabbari, 1007 Tunis, Tunisia E‐mail: maryam_kallel@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar A. Ben Osman Dhahri, A. Ben Osman Dhahri Departments of Immunology and Dermatology, La Rabta Hospital, El Jabbari, 1007 Tunis, Tunisia E‐mail: maryam_kallel@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar S. Makni S. Makni Departments of Immunology and Dermatology, La Rabta Hospital, El Jabbari, 1007 Tunis, Tunisia E‐mail: maryam_kallel@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 1, 1 January 2006, Pages 193–194, https://doi.org/10.1111/j.1365-2133.2005.07024.x Published: 01 January 2006
Cost of Drugs
Authors: L.A. Weinrauch
Journal: JAMA (1974)

To the Editor.—  Many articles have been written suggesting means by which a private physician could reduce the cost of prescription medications to his patients. The article, Equivalent Therapy at Lower Cost (228:1009, 1974), alleging to help us out of our quagmire, ignores the basic factors involved.  The practicing physician has little time to spend investigating drug prices, which are not available to him in usually accessible references.  Millions of dollars are spent each year on Task Forces to find out why physicians ignore drug prices when prescribing. The answer is really simple: We are kept in the dark by the self-interests of the various drug companies. Requests for information are usually met with statistical irrelevancies (compared with the other comparable brands, but our drug is 2.3 times more potent, etc, ad infinitum). Requests for medication prices from pharmacies show much variation, and as we all know, inpatient pricing differs
Antisense Intercellular Adhesion Molecule-1 (ICAM-1) Oligodeoxyribonucleotide Delivered During Organ Preservation Inhibits Posttransplant ICAM-1 Expression and Reduces Primary Lung Isograft Failure
Authors: Koichi Toda, Koichi Kayano, Ann Karimova, Yoshifumi Naka, Tomoyuki Fujita, Kanji Minamoto, Catherine Y. Wang, David J. Pinsky
Journal: Circulation Research (2000)

Abstract —Transiently increased expression of leukocyte adhesion receptors after lung preservation contributes to early graft demise by recruiting leukocytes, activating complement, and causing microcirculatory stasis. We hypothesized that inhibiting intercellular adhesion molecule-1 (ICAM-1) expression even briefly may significantly improve lung graft function and that the preservation period might provide a unique window to deliver a therapeutic pulse of antisense oligonucleotide ICAM-1 to inhibit ICAM-1 expression after transplantation. Interleukin-1β–treated rat pulmonary endothelial cells given a 20-mer phosphorothioate oligonucleotide comprising an antisense span targeted to the 3′-untranslated region of rat ICAM-1 demonstrated an oligonucleotide dose–dependent reduction in ICAM-1 expression. Using a cationic liposomal carrier, this same antisense oligonucleotide (but not the sense control) instilled into the pulmonary vasculature at the time of preservation reduced subsequent graft ICAM-1 expression and graft leukostasis and markedly improved oxygenation, pulmonary blood flow, and graft survival. These experiments demonstrate that the preservation period presents a window during which to target an anti–ICAM-1 expression strategy to inhibit early adhesion receptor expression and improve functional outcome after lung transplantation.
The Needs of Patients
Authors: Mitchell T. Rabkin
Journal: New England Journal of Medicine (1973)

Patients often judge their hospital experiences less from the technical quality of diagnosis and therapy received than from fulfillment of their needs for reassurance, comfort, personal dignity and awareness of the events called forth in their behalf. Within that bailiwick is the right to know about one's illness and the diagnostic procedures, other routines and behavior patterns ordained within the hospital — matters not always easy for the patient to understand. Encouraging is the recognition by health-care providers that the determinants of success, in the patients' eyes, include such mundane matters. In the past these nonphysiologic considerations may have been . . .
Understanding faith considerations when caring for bereaved Muslims
Authors: Maria Kristiansen, Aziz Sheikh
Journal: Journal of the Royal Society of Medicine (2012)

Ethnic and religious pluralism are now key features of most Western societies, with Muslims representing the largest religious minority group. Although Muslims are ethnically, culturally and linguistically heterogeneous, they share common core beliefs these centring on the unity of Allah (God) and the message sent to mankind in The Holy Qur'an. A key theme running through The Qur'an is the contrast between the transitory nature of this world and the permanent abode of the Akhirah (Hereafter).

Bereavement represents a significant life event, often resulting in major social, psychological and spiritual transitions.1 In this paper, we consider core Muslim beliefs in relation to death and bereavement, and draw on these beliefs and teachings, the limited available empirical data on the subject and our personal experiences to reflect on possible implications for care, particularly in relation to patients being managed in Western secular care contexts (see Box 1 for further details).

Box 1
Methodology


Sources of information


We searched Medline in September 2012 for relevant articles regardless of language and date of publication using a combination of the following search terms: bereavement, death, dying, grief, Muslim and Islam. Bibliographies of identified articles and personal libraries were screened.


We drew on our research data-sets, particularly the study ‘Developing services to meet the end-of-life care needs of South Asian Sikh and Muslim patients and their families in Scotland’ and an ongoing Danish study on ethnicity, migration and cancer care.2


Our own experiences of witnessing and caring for bereaved individuals were an additional source of information. These experiences are based on research among, as well as personal relations to, bereaved Muslims and the healthcare professionals caring for them.
Pollution and Child Health
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cyclosporin A and cutaneous malignancy
Authors: M.L. Price, M.J. Tidman, E. Young, R.W. Groves, D.M. MacDonald
Journal: British Journal of Dermatology (1985)

Cyclosporin A has been demonstrated to be an effective alternative to conventional immunosuppressive agents, such as azathioprine and prednisolone, in promoting successful organ transplantation. Although the association between immunosuppression and the development of skin malignancy has been well documented, the cutaneous carcinogenic potential of cyclosporin remains uncertain. This report concerns two recipients of renal allografts, in whom conversion from azathioprine and prednisolone to cyclosporin A was followed by the development of a variety of hyperplastic, dysplastic and malignant cutaneous lesions. These ranged from a keratoacanthoma with small foci of dysplasia and viral wartsshowing marked dysplastic changes, to carcinoma in situ and frank invasive anaplastic squamous cell carcinoma. Furthermore, in both cases the distribution of these proliferative lesions was confined to sun-exposed regions of the body. Although both subjects were immunosuppressed for 8 and 12 years respectively prior to the change in their therapy, the temporal relationship between conversion and the appearance of dysplastic and malignant lesions provides strong circumstantial evidence for incriminating cyclosporin A particularly in their genesis. In addition, their localizaton to sun-exposed areas suggests that ultraviolet light plays a role in their pathogenesis and highlights the need for sun avoidance in transplanted patients.
Doctors Monro: A Medical Saga
Authors: Lester S. King
Journal: JAMA (1964)

Foremost, perhaps, among the world's medical families are the doctors Monro of Edinburgh. Best known are the Alexander Munros who,<i>primus, secundus</i>, and<i>tertius</i>, occupied between them the chair of anatomy at Edinburgh for 126 years. This branch of the family contained eight generations of physicians, all descended from Sir Alexander Monro of Bearcrofts, who died in 1704. Dr. Wright-St. Clair, a New Zealander, has performed a splendid service in depicting the family. He has paid special attention to five generations of physicians, from John (1670-1740) through the three Alexanders (1697-1859) to David (1813-1877). The latter, son of<i>tertius</i>, secured his MD at Edinburgh in 1835 but soon emigrated to New Zealand, where he became prominent in political life. The text rests firmly on examination of original sources, largely manuscripts, including diaries, letters and journals, student notes, minutes of the Royal Colleges in Edinburgh, the Edinburgh City Council minutes and
Erythrokinetics in Diabetes Mellitus.
Authors: Spencer W. Burney
Journal: Annals of Internal Medicine (1968)

s1 May 1968Erythrokinetics in Diabetes Mellitus.Spencer W. Burney, M.D., Gilbert H. Friedeil, M.D., Donald M. Barnett, M.D.Spencer W. Burney, M.D.Search for more papers by this author, Gilbert H. Friedeil, M.D.Search for more papers by this author, Donald M. Barnett, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1166_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAnemia is not infrequently found in diabetic patients. In addition, Rosen and Tullis (JAMA195: 261, 1966) have reported abnormally low deferoxamine chelation values in nonanemic diabetic patients suggesting that there is a defect in iron metabolism associated with this disease. The erythrokinetics in 42 non-iron-deficient diabetic patients were therefore studied. These 42 patients included about 17 without anemia or clinical evidence of renal disease, 11 with anemia but without renal disease, and 14 with both anemia and renal disease. Although there is some overlapping of values for individual patients in the 3 groups, each group has a combination of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1166-1166KeywordsAnemiaDiabetes mellitusRenal diseases Issue Published: 1 May 1968 PDF DownloadLoading ...
1128-126 Increased vascular stiffness and impaired ejection fraction in older patients following first transmural myocardial infarction
Authors: Kavita V Ernst, Gary Gerstenblith, Lewis C Becker, David Kass, Susan Townsend, Ann Capriotti, Rosalie Cosgriff, Michael Terrin, Sandra Forman, Steven P Schulman
Journal: Journal of the American College of Cardiology (2004)
Book Review Neurocritical Care Edited by Werner Hacke, with Daniel F. Hanley, Karl M. Einhaupl, Thomas P. Bleck, Michael N. Diringer, Allan H. Ropper, and Klaus Sartor. 1044 pp., illustrated. New York, Springer-Verlag, 1994. $98. 0-387-56443-8
Authors: Philip Stieg
Journal: New England Journal of Medicine (1994)
Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding
Authors: J. Sung, D. Luo, J. Wu, J. Ching, F. Chan, J. Lau, S. Mack, R. Ducharme, P. Okolo, M. Canto, A. Kalloo, S. Giday
Journal: Endoscopy (2011)

Background and study aims: Endoscopic therapy of upper gastrointestinal bleeding remains challenging with conventional endoscopic devices. Use of Hemospray, where a nanopowder with clotting abilities is sprayed onto the bleeding site, had been highly effective for management of arterial bleeding in a heparizined animal model. The safety and effectiveness of Hemospray for hemostasis of active peptic ulcer bleeding in humans was evaluated.
Case of Ovarian Tumour Successfully Removed
Authors: J. Dickin
Journal: BMJ (1845)

presented herself at the Salop Infirmary on the 5th of last April.She stated that about eighteen months ago she observed her abdomen to be larger than it should be, and that it had been graduially increasing in size up to the above date.Her appearance niuch resenmbled that of a female far advanced in pregnancy; and on making
Complement activation in patients with primary antiphospholipid syndrome
Authors: K Oku, T Atsumi, M Bohgaki, O Amengual, H Kataoka, T Horita, S Yasuda, T Koike
Journal: Annals of the Rheumatic Diseases (2008)

To investigate the significance of complement activation in patients with primary antiphospholipid syndrome (APS).Thirty-six patients with primary APS, 42 control patients with non-systemic lupus erythematosus (SLE) connective tissue diseases, and 36 healthy volunteers were analysed retrospectively. Serum complement levels (C3, C4, CH(50)) and anaphylatoxins (C3a, C4a, C5a) were examined in all subjects, and serum complement regulatory factors (factor H and factor I) were measured in patients with primary APS. Plasma anticoagulant activity was determined in a mixing test using the activated partial thromboplastin time.Serum complement levels were significantly lower in patients with primary APS than in patients with non-SLE connective tissue diseases (mean (SD) C3: 81.07 (17.86) vs 109.80 (22.76) mg/dl, p<0.001; C4: 13.04 (8.49) vs 21.70 (6.96) mg/dl, p<0.001; CH(50): 31.32 (8.76) vs 41.40 (7.70) U/ml, p<0.001) or healthy volunteers. Only two healthy subjects with low serum C4 levels showed hypocomplementaemia, whereas most patients with primary APS showed raised serum C3a and C4a. No subjects showed raised C5a. Patients with primary APS with low serum C3 or C4 had significantly higher levels of C3a or C4a than healthy controls. No patients had low serum complement regulatory factors. Among patients with primary APS, hypocomplementaemia was significantly more common in those with high anticoagulant activity than in those with low or normal activity.Hypocomplementaemia is common in patients with primary APS, reflecting complement activation and consumption, and was correlated with anticoagulant activity, suggesting that antiphospholipid antibodies may activate monocytes and macrophages via anaphylatoxins produced in complement activation.
CEREBRAL ANAEROBIC GLYCOLYSIS AND REDUCED CEREBRAL OXYGEN TRANSPORT IN HUMAN CEREBRAL MALARIA
Authors: D.A. Warrell, N. Veall, P. Chanthavanich, Juntra Karbwang, N.J. White, S. Looareesuwan, R.E. Phillips, Praneet Pongpaew
Journal: The Lancet (1988)
Natural History and Molecular Characteristics of Lung Cancers Harboring EGFR Exon 20 Insertions
Authors: Geoffrey R. Oxnard, Peter C. Lo, Mizuki Nishino, Suzanne E. Dahlberg, Neal I. Lindeman, Mohit Butaney, David M. Jackman, Bruce E. Johnson, Pasi A. Jänne
Journal: Journal of Thoracic Oncology (2013)
450 Interim report on a phase I/IIA, double-blind, randomized, placebo-controlled trial of a novel antiviral agent, LB80380 in Chinese patients with chronic hepatitis B infection
Authors: M.F. Yuen, J. Kim, D.K.H. Wong, V.W.S. Ngai, J.C.H. Yuen, C.L. Lai
Journal: Journal of Hepatology (2004)