Primary Sclerosing Cholangitis Associated with Membranous Nephropathy
Authors: LUC VERRESEN
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Primary Sclerosing Cholangitis Associated with Membranous NephropathyLUC VERRESEN, M.D., MARC WAER, M.D., RENÉ VERBERCKMOES, M.D., PAUL MORIAS, M.D., PAUL MICHIELSEN, M.D.LUC VERRESEN, M.D.Search for more papers by this author, MARC WAER, M.D.Search for more papers by this author, RENÉ VERBERCKMOES, M.D.Search for more papers by this author, PAUL MORIAS, M.D.Search for more papers by this author, PAUL MICHIELSEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-909_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe report the case of a patient with primary sclerosing cholangitis associated with membranous nephropathy.A 41-year-old man had edema and fatigue. Serum albumin was 9.9 g/L (normal, 36 to 53) creatinine, 109.7 µmol/L (normal, 61 to 119); creatinine clearance, 77.6 mL/min; alkaline phosphatase, 680 U/L (normal, 40 to 130); gamma-glutamyl transpeptidase, 730 U/L (normal, 5 to 24); and a 4+ test for immune complexes (rheumatoid arthritis factor binding assay). Urine analysis showed proteinuria (20 g/d) and 44 dysmorphic erythrocytes/mm3. Tests for mitochondrial antibodies and hepatitis B surface antigen (HBsAg) were negative.A renal biopsy was done. The only abnormal...References1. FEE H, GEWIRTZ H, SCHILLER J, and LONGMIRE W. Sclerosing cholangitis and primary biliary cirrhosis—a disease spectrum? Ann Surg. 1977;186:589-93. CrossrefMedlineGoogle Scholar2. RAI G, HAMLYN A, DAHL M, MORLEY A, and WILKINSON R. Primary biliary cirrhosis, cutaneous capillaritis, and IgM-associated membranous glomerulonephritis. Br Med J. 1977; 1:817. CrossrefMedlineGoogle Scholar3. PALS S, RADASZKIEWICZ T, ROOZENDAAL L, and GLEICHMANN E. Chronic progressive polyarthritis and other symptoms of collagen vascular disease induced by graft-vs-host reaction. J Immunol. 1985;134:1475-82. CrossrefMedlineGoogle Scholar4. MCFARLANE I, WOJCICKA B, TSANTOULAS D, PORTMANN B, EDDLESTON A, and WILLIAMS R. Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases. Gastroenterology. 1979;76:1333-40. CrossrefMedlineGoogle Scholar5. BODENHEIMER H, LARUSSO N, THAYER W, CHARLAND C, STAPLES P, and LUDWIG J. Elevated circulating immune complexes in primary sclerosing cholangitis. Hepatology. 1983;3:150-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LUC VERRESEN, M.D.; MARC WAER, M.D.; RENÉ VERBERCKMOES, M.D.; PAUL MORIAS, M.D.; PAUL MICHIELSEN, M.D.Affiliations: Universitair Ziekenhuis Gasthuisberg Leuven Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLiver disorders linked with renal dysfunction: A physician's perspectiveMembranous Nephropathy Associated With Immunological Disorder-Related Liver DiseaseMembranous glomerulonephritis associated with hepatitis C virus infection in an adolescentPrimary sclerosing cholangitisCorrection: Letter on Primary Sclerosing Cholangitis 1 June 1988Volume 108, Issue 6Page: 909-910KeywordsCreatinineFatigueHepatitis B surface antigenImmune complexPhosphatasesPrimary sclerosing cholangitisProteinuriaRheumatoid arthritisSerum albuminUrine ePublished: 1 December 2008 Issue Published: 1 June 1988 PDF downloadLoading ...