tbuckley/cabot-search huggingface dataset:
Placement of Peritoneal Catheters
Authors: Karl D. Nolph
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 December 1988Placement of Peritoneal CathetersKarl D. Nolph, MDKarl D. Nolph, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-12-989_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The position (1) paper on clinical competence in acute peritoneal dialysis urges that bedside techniques for placing peritoneal catheters be practiced in nephrology programs. Like clinicians in many, if not most, larger nephrology programs, we prefer placing soft "chronic" peritoneal catheters rather than the more rigid stylet catheters for treating patients with acute renal failure as discussed elsewhere (2). Briefly, use of such placement avoids repeated abdominal punctures for intermittent therapies, allows greater mobility and comfort during the treatment, permits the use of continuous peritoneal dialysis (even ambulatory in some patients), and eases the transition to chronic...References1. . Clinical competence in acute peritoneal dialysis. Ann Intern Med. 1988;108:763-5. LinkGoogle Scholar2. Nolph K. Peritoneal dialysis in acute renal failure. In: Brenner BM, Lazarus JM, eds. Acute Renal Failure. New York: Churchill Livingstone; 1988:809. Google Scholar3. KatirtzoglovKontesisMyopoulou-Symvoulidis APD. Continuous equilibration peritoneal dialysis (CEPD) in hypercatabolic renal failure. Perit Dial Bull. 1983;3:178. CrossrefGoogle Scholar4. TwardowskiNolphKhannaProwantRyanNichols ZKRBLW. The need for a "swan neck" permanently bent, arcuate peritoneal dialysis catheter. Perit Dial Bull. 1985;5:219-23. CrossrefGoogle Scholar5. TwardowskiNolph ZK. Blood purification in acute renal failure (editorial). Ann Intern Med. 1984;100:447-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Karl D. Nolph, MDAffiliations: University of Missouri Health Sciences Center Columbia, MO 65212 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeritoneal Access Technology 15 December 1988Volume 109, Issue 12Page: 989-989KeywordsAcute renal failureCathetersNephrologyPeritoneal dialysis ePublished: 1 December 2008 Issue Published: 15 December 1988 PDF downloadLoading ...
Clinical primary pulmonary hypertension: three pathologic types.
Authors: W D Edwards, J E Edwards
Journal: Circulation (1977)

Clinically, there is a group of patients with elevated pulmonary arterial pressure in whom the underlying cause is not apparent. The pulmonary arterial wedge pressure is not elevated. For such cases, the designation of primary pulmonary hypertension may be made clinically. From the clinical categorization of primary pulmonary hypertension, three distinct pathologic entities emerge, namely 1) plexogenic pulmonary arteriopathy, 2) recurrent pulmonary thromboembolism, and 3) pulmonary veno-occlusive disease. The plexogenic type is characterized initially by pulmonary arterial vasoconstriction with medial hypertrophy. Secondary proliferative intimal lesions, including the plexiform lesion, develop. Recurrent pulmonary thromboembolism is characterized by the presence of arterial thrombi of varying ages involving the microscopic-sized pulmonary arteries. Thrombi may be embolic in nature or may develop in situ. Pulmonary veno-occlusive disease is characterized by obstructive lesions of pulmonary veins and venules. The clinical presentation of the three pathologic types may be so similar that definitive diagnosis depends upon histologic examination of the lung from tissue obtained either by biopsy or at necropsy.
Abstract 3906: Magnolol suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways.
Authors: Ki Mo Kim, No Soo Kim, Jinhee Kim, Jong-Shik Park, Jin Mu Yi, Jun Lee, Ok-Sun Bang
Journal: Cancer Research (2013)

Abstract Magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, has been reported to possess anti-cancer activity. Recent studies have also demonstrated that magnolol inhibits cell growth and induces the apoptosis of cancer cells. However, the effects of magnolol on vascular endothelial growth factor (VEGF)-induced angiogenesis in endothelial cells have not been studied. In the present study, we have used human umbilical vein endothelial cells (HUVECs) to investigate the anti-angiogenic effect and molecular mechanism of magnolol. Magnolol inhibited the VEGF-induced proliferation, chemotactic motility and tube formation of HUVECs in vitro as well as the vessel sprouting of the aorta ex vivo. Furthermore, magnolol inhibited VEGF-induced Ras activation and subsequently suppressed extracellular signal-regulated kinase (ERK), phosphatidylinositol-3-kinase (PI3K)/Akt and p38, but not Src and focal adhesion kinase (FAK). Interestingly, the knockdown of Ras by short interfering RNA produced inhibitory effects that were similar to the effects of magnolol on VEGF-induced angiogenic signaling events, such as ERK and Akt/eNOS activation, and resulted in the inhibition of proliferation, migration, and vessel sprouting in HUVECs. In combination, these results demonstrate that magnolol is an inhibitor of angiogenesis and suggest that this compound could be a potential candidate in the treatment of angiogenesis-related diseases. Citation Format: Ki Mo Kim, No Soo Kim, Jinhee Kim, Jong-Shik Park, Jin Mu Yi, Jun Lee, Ok-Sun Bang. Magnolol suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3906. doi:10.1158/1538-7445.AM2013-3906
Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration
Authors: Abdoulaye Sene, Aslam A. Khan, Douglas Cox, Rei E.I. Nakamura, Andrea Santeford, Bryan M. Kim, Rohini Sidhu, Michael D. Onken, J. William Harbour, Shira Hagbi-Levi, Itay Chowers, Peter A. Edwards, Angel Baldan, John S. Parks, Daniel S. Ory, Rajendra S. Apte
Journal: Cell Metabolism (2013)
Psychological Aspects of Primary Aldosteronism
Authors: Nicoletta Sonino, Francesco Fallo, Giovanni A. Fava
Journal: Psychotherapy and Psychosomatics (2006)

Except for 3 case reports of Conn's syndrome presenting as depression, psychosocial factors have not been explored in primary aldosteronism. We investigated psychological correlates in primary aldosteronism using methods that were found to be sensitive and reliable in psychosomatic research.Ten consecutive newly diagnosed patients with primary aldosteronism were studied: 5 males/5 females; mean age (+/-SD) 45.5 +/- 6.6 years, age range 34-54 years; 4 with an aldosterone-producing adenoma and 6 with idiopathic aldosteronism; systolic/diastolic blood pressure 189 +/- 20/111 +/- 7.7 mm Hg; upright plasma aldosterone 40.0 +/- 18.3 ng/dl; upright plasma renin activity (PRA) 0.2 +/- 0.1 ng/ml/h; aldosterone/PRA ratio 229.2 +/- 191.0; serum K(+) 3.5 +/- 0.5 mmol/l. The Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) for eliciting psychiatric diagnoses, and a shortened version of the structured interview for subclinical psychological syndromes, the Diagnostic Criteria for Psychosomatic Research (DCPR), were administered.Seven patients (2 with aldosterone-producing adenoma and 5 with idiopathic hyperaldosteronism) received both DSM-IV and DCPR diagnoses, while 3 had neither. As to DSM-IV, generalized anxiety disorder was detected in 6 cases (in 1 it was associated with panic disorder and in 1 with major depression) and obsessive-compulsive disorder in 1. The most frequent DCPR cluster was demoralization (5 cases), while persistent somatization occurred in 2 cases (associated with demoralization in 1) and irritable mood in 1.The occurrence of anxiety disorders in patients with primary aldosteronism was much higher than that found in the general population and in primary care. Since an association between hyperaldosteronism and anxiety has also been suggested in previous animal studies, it seems worthwhile to gain further knowledge on clinical aspects by larger population studies.
Animal Models in Diabetes and Pregnancy
Authors: Alicia Jawerbaum, Verónica White
Journal: Endocrine Reviews (2010)

The worldwide increase in the incidence of diabetes, the increase in type 2 diabetes in women at reproductive ages, and the cross-generation of the intrauterine programming of type 2 diabetes are the bases for the growing interest in the use of experimental diabetic models in order to gain insight into the mechanisms of induction of developmental alterations in maternal diabetes. In this scenario, experimental models that present the most common features of diabetes in pregnancy are highly required. Several important aspects of human diabetic pregnancies such as the increased rates of spontaneous abortions, malformations, fetoplacental impairments, and offspring diseases in later life can be approached by using the appropriate animal models. The purpose of this review is to give a practical and critical guide into the most frequently used experimental models in diabetes and pregnancy, discuss their advantages and limitations, and describe the aspects of diabetes and pregnancy for which these models are thought to be adequate. This review provides a comprehensive view and an extensive analysis of the different models and phenotypes addressed in diabetic animals throughout pregnancy. The review includes an analysis of the surgical, chemical-induced, and genetic experimental models of diabetes and an evaluation of their use to analyze early pregnancy defects, induction of congenital malformations, placental and fetal alterations, and the intrauterine programming of metabolic diseases in the offspring's later life.
Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells
Authors: Y LIN, C MA, W HSU, H LO, V YANG
Journal: Cardiovascular Research (2007)

Objective Caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) are proteins that are involved in cellular cholesterol efflux. In this study, we analyzed the relationships between caveolin-1 and ABCA1 on high-density lipoprotein (HDL)-mediated cholesterol efflux in rat aortic endothelial cells.
MYELOID SARCOMA OF THE FEMUR, WITH PATHOLOGICAL FRACTURE
Authors: W. S. George, A. H. Todd
Journal: BMJ (1915)

lITI MYELOID SARCOMIA OF THE FEMUR.[APRIL , T1915 every tllree daysI The nuiimber shows, nlo telndency to diminish, but rather the opposite.Levv lias analysed 109 fatal cases.'In nio inistalnce was tlere any evidence of ovcr-dosag;,.fid in 87 per' cenlt. of tlieiii there is evi- denee that the patient wvas in a state of lighlt alnaes- tlhesia.He develop.s the view that the exact ca-ixse of dleatlh is deliriumiii cordis, ventricuLlar fibrillation, and stulports hlis tlheory b.y a series of very convincinig experilllents upon cats.Levy believes that unider light ulhloroform anaestlhesia tle, hleart is in a condition whicll is peculiarly liable to fibrillation.In this stage a variety of situi mlay precipitate fibrillationi.The inijection of a cnilalii is a miiost potelnt stimiu-ilus, and rarely failed to 1iil a cat unider liglht clhloroform narcosis.It is niowv
Serum Sickness Due To Turkey Escherichia coli Vaccine
Authors: R. W. Montgomery
Journal: JAMA (1974)

<h3>To the Editor.—</h3> A 50-year-old turkey farmer accidentally vaccinated himself with a mixture of six autogenous<i>Escherichia coli</i>strains intended for turkeys. This is a new and still experimental vaccine that had not been used before. Symptoms consisted of a local reaction involving most of his forearm, followed in a few days by remote itching and hives lasting approximately three weeks. This was followed by tingling and paresthesia of both hands and later both feet and toes. After a few days of the paresthesia, joint pain and swelling occurred in the small joints of hands and feet, which subsided rapidly with institution of aspirin, 15 grains four times daily. The paresthesia lasted approximately three weeks further, giving a total duration of the illness of approximately 12 weeks. The patient discounted his symptoms and carried on normal activities. Steroids were not used. Sedimentation rate, urinalysis, serum complement, heterophil, VDRL and RA
Lovastatin and Visual Changes
Authors: Frank W. Newell
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 June 1989Lovastatin and Visual ChangesFrank W. Newell, MDFrank W. Newell, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-11-944 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The recently published letter by Mieczkowski and Holahan (1) does not provide evidence of any lovastatin-related changes in the eye. There is no evidence to suggest any ocular abnormality, other than a reduction in the power of the lens used to correct myopic astigmatism. The authors state that 5 weeks after initiation of lovastatin therapy the patient's eyes were examined. The eyes were examined 6 months earlier, but the authors do not state whether both examinations were done by the same examiner; whether the examination included dilation of the pupils; whether the refractive changes occurred in both...References1. Mieczkowski L and Holahan J. Lovastatin and visual changes [Letter]. Ann Intern Med. 1989;110:410-11. LinkGoogle Scholar2. Fraunfelder F. Ocular examination before initiation of lovastatin (Mevacor) therapy. Am J Ophthalmol. 1988;105:91-2. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Frank W. Newell, MDAffiliations: University of Chicago Chicago, IL 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1989Volume 110, Issue 11 Page: 944-944 ePublished: 1 December 2008 Issue Published: 1 June 1989 PDF downloadLoading ...
Low-Dosage Glucocorticoid Therapy.
Authors: William McK. Jefferies
Journal: Annals of Internal Medicine (1966)

s1 May 1966Low-Dosage Glucocorticoid Therapy.William McK. Jefferies, M.D., F.A.C.P.William McK. Jefferies, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1184_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTherapeutic effectiveness of glucocorticoids in clinical disorders has been thought to depend upon production of a state of hypercorticism with its accompanying hazards. As experience has accumulated, it has become apparent that doses of cortisone acetate too small to produce hypercorticism may have clinically beneficial effects in arthritic and allergic diseases as well as in some cases of ovarian dysfunction, hirsutism, acne, and chronic cystic mastitis.In studies of the effects of low-dosage glucocorticoid therapy in over 200 patients with various disorders for periods up to 8 years, it has been found that (1) these doses can significantly affect steroid... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1184-1184KeywordsAcneAllergic diseasesGlucocorticoid therapy Issue Published: 1 May 1966 PDF DownloadLoading ...
Lettsomian Lectures on some Points in the Surgery of the Urinary Organs
Authors: R. Harrison
Journal: BMJ (1888)

THE surgery of the bladder during the last ten years will, under 1 all circumstances, occupy a conspicuous position in the history of our art by the introduction of litliolapaxy, the revival of the suprapubic or high operation under somewhat altered conditions, and by an approach to a more sytematic method of treating tumours and growths connected with the interior of the viscus, It has been my privilege to watchl the progress of these several procedures, not merely as a passive critic, but as an active participator with others in all the advantages these measures have proposed to confer.Within the period mentioned a vast amount of experience has already been obtained bearing upon these various proposals, and I think the time this evening cannot be better oc- cupied than in drawing some conclusions in regard to them which seem to me may now be fairly and adv,antageously done; and, in referring to these several procedures, I will endeavour, in speaking of each, to indicate what appears to me to be their strong as well as their weak points, and to what extent our present experience tends to show they lhave justified the anticipations with which they were promulgated.in the course of tlhese remarks I shall not trouble you witlh statistics relative to operative procedures, as I do not attach much importance to tlhem.It seems to me that in drawing conclusions from figures of this kind, gathered from various sources, we are putting oursel-es much in the same position as the individual who, to make sure about the weather, consults three different kinds of barometer, and is rewarded by finding them respectively indicating at thie same time " stormy," "rain, ' and " very fine."From such variations as these most persons would be disposed to conclude, not that it was safe to go out without an umbrella, but that at least two of the instruments must in some respect be faulty.On the other hand, to the collec- tive work of individuals carefully recor(led, with all failures and successes, the greatest importance is to be attached, as indicating not only results, but how these were obtained.In the first place I will take a brief survey of the position that the crushing operation seems to occupy at the present day.Since the procedure wlhicil is justly associated with the name of Dr. Bigelow, of Boston, was brouglht uinder notice, exactly ten years ago this month, it has been applied to almost every condition under which stone in the bladder is met with in males, females, and children.Without entering into the history of the modern
Endothelial Regulation of Vasomotion in ApoE-Deficient Mice
Authors: Jørn Bech Laursen, Mark Somers, Sabine Kurz, Louise McCann, Ascan Warnholtz, Bruce A. Freeman, Margaret Tarpey, Tohru Fukai, David G. Harrison
Journal: Circulation (2001)

Background —Altered endothelial cell nitric oxide (NO · ) production in atherosclerosis may be due to a reduction of intracellular tetrahydrobiopterin, which is a critical cofactor for NO synthase (NOS). In addition, previous literature suggests that inactivation of NO · by increased vascular production superoxide (O 2 ·− ) also reduces NO · bioactivity in several disease states. We sought to determine whether these 2 seemingly disparate mechanisms were related. Methods and Results —Endothelium-dependent vasodilation was abnormal in aortas of apoE-deficient (apoE −/− ) mice, whereas vascular superoxide production (assessed by 5 μmol/L lucigenin) was markedly increased. Treatment with either liposome-entrapped superoxide dismutase or sepiapterin, a precursor to tetrahydrobiopterin, improved endothelium-dependent vasodilation in aortas from apoE −/− mice. Hydrogen peroxide had no effect on the decay of tetrahydrobiopterin, as monitored spectrophotometrically. In contrast, superoxide modestly and peroxynitrite strikingly increased the decay of tetrahydrobiopterin over 500 seconds. Luminol chemiluminescence, inhibitable by the peroxynitrite scavengers ebselen and uric acid, was markedly increased in apoE −/− aortic rings. In vessels from apoE −/− mice, uric acid improved endothelium-dependent relaxation while having no effect in vessels from control mice. Treatment of normal aortas with exogenous peroxynitrite dramatically increased vascular O 2 ·− production, seemingly from eNOS, because this effect was absent in vessels lacking endothelium, was blocked by NOS inhibition, and did not occur in vessels from mice lacking eNOS. Conclusions —Reactive oxygen species may alter endothelium-dependent vascular relaxation not only by the interaction of O 2 ·− with NO · but also through interactions between peroxynitrite and tetrahydrobiopterin. Peroxynitrite oxidation of tetrahydrobiopterin may represent a pathogenic cause of “uncoupling” of NO synthase.
Management of Medical Problems in Pregnancy — Severe Cardiac Disease
Authors: Jay M. Sullivan, K.B. Ramanathan
Journal: New England Journal of Medicine (1985)

Although both maternal and cardiovascular mortality have declined during the past decade, the apparent prevalence of cardiovascular disorders in pregnant patients has remained relatively constant because of three medical advances. These include more accurate diagnostic techniques; improved management, which now makes pregnancy possible for some women who might not have attempted childbirth in the past; and surgical correction of congenital cardiac lesions, which has created a new category of patients reaching childbearing age. The prevalence of heart disease during pregnancy ranges from 0.4 to 4.1 per cent, and maternal mortality ranges from 0.4 per cent among patients in Class I . . .
Studies in Human Atrial Flutter with the Use of Proximity Electrodes
Authors: YEHEZKIEL KISHON, RALPH E. SMITH
Journal: Circulation (1969)

Ten patients with the electrocardiographic diagnosis of atrial flutter were investigated by exploration with electrodes within the esophagus and the right atrium. The records obtained were studied in regard to the timing of the intrinsic deflection and the contour of the atrial waves, as recorded at various sites. In four patients, atrial activation progressed in sequence cephalad in the left atrial wall and caudad in the right atrium. This process continued through two thirds of the total atrial cycle, favoring "circus movement" as the underlying mechanism. In six other patients, activation was believed to originate low in the left atrium, with simultaneous spread of excitation of both atrial walls in a general cephalad direction and terminating within the first half (usually the first third) of the atrial cycle. This pattern is compatible with, but not conclusive of, an ectopic focal mechanism. Serial records in one patient are presented in which transformation of one type into a second type of atrial flutter is suggested. It is likely that at least two mechanisms are present in human atrial flutter.