tbuckley/cabot-search huggingface dataset:
Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment
Authors: Florian P. Limbourg, Stefanie Ringes‐Lichtenberg, Arnd Schaefer, Christoph Jacoby, Yasmin Mehraein, Mark D. Jäger, Anne Limbourg, Martin Fuchs, Gunnar Klein, Matthias Ballmaier, Hans‐J. Schlitt, Juergen Schrader, Denise Hilfiker‐Kleiner, Helmut Drexler
Journal: European Journal of Heart Failure (2005)
New deal shifts may increase house officers' stress
Authors: C. Grainger, E. Harries, G. Ingrams
Journal: BMJ (1995)

EDITOR,--The new deal was implemented to improve the working conditions of junior doctors by reducing the total hours worked and, where the intensity of work was high, by changing the pattern of working from a traditional on call rota to full or partial shifts.1 No research has been carried out, however, to assess whether the change from an on call rota to full or partial shifts in high intensity jobs has achieved the beneficial effect initially predicted.

Two postal surveys of junior doctors were conducted in the west midlands, the first on all preregistration house officers trained in Britain who were working in the region and the second on a random sample of senior house officers working in the region. Both surveys …
Role of Retrograde His Purkinje Block in the Initiation of Supraventricular Tachycardia by Ventricular Premature Stimulation in the Wolff-Parkinson-White Syndrome
Authors: Masood Akhtar, Mohammad Shenasa, Donald H. Schmidt
Journal: Journal of Clinical Investigation (1981)

The precise mechanisms for paroxysmal reentrant supraventricular tachycardia (PSVT) initiation during right ventricular premature stimulation (V(2) method) were analyzed in 14 consecutive patients with Wolff-Parkinson-White Syndrome in whom the PSVT was inducible during retrograde refractory period studies. 9 patients had left-sided and the remaining 5 of 14 had right-sided ventriculo-atrial (VA) accessory pathway (AP). At the basic cycle lengths (V(1)V(1)) ranging from 550 to 900 ms (mean, 657.1+/-139.5), closely coupled V(2) (mean V(1)V(2), 357.3+/-59.2 ms, range 320-500) produced retrograde His bundle (H(2)) activation via the bundle branches and retrograde atrial (A(2)) activation via the AP. As the V(1)V(2) were further shortened, the V(2) showed a retrograde block in the His Purkinje system (HPS) and conducted to the atria via AP in 9 of 14 cases. Subsequently, the A(2) impulse conducted anterograde over the atrioventricular node-HPS to initiate a PSVT or an atrial echo response in all nine cases. In none of the patients was a PSVT induced by V(2) when the latter produced retrograde H(2) activation via the bundle branches. In 10 of 14 cases, however, the retrograde H(2) was followed by a V(3), due to macroreentry in the HPS. The V(3) in turn blocked retrogradely in the HPS while producing A(3) via the AP to initiate a PSVT or an atrial echo response in 9 of 10 cases. Retrograde block of V(2) and/or V(3) in the HPS resulted in PSVT initiation in 13 of 14 cases, whereas in the remaining 1 case the exact mechanism was not clear. In none of the patients in this series was the PSVT initiated with a retrograde block of V(2) in the atrioventricular node with or without concomitant retrograde A(2) activation via the AP. We conclude that within the ranges of cycle lengths tested, a retrograde block of V(2) and/or V(3) in the HPS is the most common mechanism for initiation of PSVT during ventricular premature stimulation in patients with the Wolff-Parkinson-White Syndrome.
Interleukin-11 reduces T-cell-dependent experimental liver injury in mice
Authors: Mary Bozza, Judith L. Bliss, Richard Maylor, Jamie Erickson, Lori Donnelly, Page Bouchard, Andrew J. Dorner, William L. Trepicchio
Journal: Hepatology (1999)

Recombinant human interleukin-11 (rhIL-11) is a multifunctional cytokine that can reduce inflammation through the downregulation of multiple pro-inflammatory mediators from activated macrophages. rhIL-11 also inhibits production of several immunostimulatory cytokines such as IL-12 and interferon gamma (IFN-gamma) and has shown biological activity in multiple animal models of inflammatory disease consistent with immunomodulatory effects on macrophages and T cells. To further elucidate the anti-inflammatory activity of rhIL-11 in vivo, the effect of rhIL-11 in a model of Concanavalin A (Con-A)-induced T-cell-mediated hepatotoxicity was examined. Administration of a single dose of rhIL-11 before Con-A administration reduced centrilobular liver necrosis and enhanced survival. A dose-dependent reduction in serum levels of liver enzymes, tumor necrosis factor alpha (TNF-alpha), and IFN-gamma corresponded with this amelioration of liver damage. No significant change in infiltrating lymphocyte populations in the liver was observed following rhIL-11 treatment. Taken together, these results indicate that rhIL-11 ameliorates T-cell-mediated hepatic injury and suggests its therapeutic potential to treat inflammatory liver disease.
Science, medicine, and the future: Artificial limbs
Authors: L. J Marks, J. W Michael
Journal: BMJ (2001)

<b>Objective.</b> To determine if exposure to an intervention course impacts pharmacy students’ mental health stigma (MHS) and mental health knowledge (MHK). <b>Methods.</b> A one-group pre/posttest intervention study of third-year pharmacy students (N=120) was conducted. Dependent variables were subdomains of MHS (recovery, safety, disclosure, separation, comfort) which were measured on a 5-point Likert scale (1=strongly disagree; 5=strongly agree). Mental health knowledge was measured with 10 true/false questions. The 2.5-hour intervention included presentations, videos, discussions, and active-learning exercises. Pre/posttests were administered, and data were analyzed using paired <i>t</i> tests and McNemar’s tests. <b>Results.</b> Among responding students (n=88; 73.3% response rate), the following stigma subdomains significantly decreased after the intervention for depression and schizophrenia: recovery, safety, separation, and comfort. Mental health knowledge scores significantly increased from 5.9 (1.5) to 6.8 (1.5). <b>Conclusion.</b> Pharmacy students’ MHS and MHK related to depression and schizophrenia can be improved through a brief and interactive anti-stigma intervention.
On Talking with a Patient
Authors: JOSEPH M. CONNORS
Journal: Annals of Internal Medicine (1984)

Ad Libitum1 January 1984On Talking with a PatientJOSEPH M. CONNORS, M.D.JOSEPH M. CONNORS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-166_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"They expect us for dinner at 7:30," my wife had said. The chair beside the bed was too low. I looked up into his 70-year-old eyes, turned aside lest they see me as I brought the unwanted news; across at the large-fingered calloused hands, holding each other for lack of a tool. A lytic lesion in L3 had brought pain, discovery of a mass in the upper left lung, and now an end to 40 years of smoking. What else could my news be but bad, hurriedly delivered on Friday evening, the "reason why you are feeling the pain and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Wrong PatientJames G. Gallagher, MD 1 January 1984Volume 100, Issue 1Page: 166-166KeywordsEmotionsLesionsLungs Issue Published: 1 January 1984 PDF downloadLoading ...
A Pain in the Neck
Authors: Javier Munoz, Haythem Ali
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular analysis during Con A-induced liver failure suggests the relevance of Jun kinase and IRF-1 for hepatocyte injury
Authors: K.L. Streetz, B. Fregien, J. Plmpe, K. Krber, S. Kubicka, G. Sass, M.P. Manns, G. Tiegs, C. Trautwein
Journal: Journal of Hepatology (2001)
Congenital Arteriovenous Fistulation of the Lower Limb
Authors: Field C. Leonard, George A. Vassos
Journal: New England Journal of Medicine (1951)

FAILURE of endothelial closure between primordial arteries and veins results in a complex of multiple arteriovenous shunts without intervening capillary bed. As compared to the simple traumatic variety, these congenital shunts are almost always multiple, and the term "fistulation" is hereinafter used to emphasize this multiplicity. Considering the intricacies of vascular embryology, it is remarkable that the condition is not more frequently seen. By the time it is discovered, congenital fistulation is usually already slowly expanding and has become destructive. By pressure erosions, nonmalignant "invasion" of adjacent muscle, bone, nerves and other structures gives rise to the false impression of . . .
Studying oxygen's life-and-death roles if taken from or reintroduced into tissue
Authors: J. Zylke
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case of Strangulated Diaphragmatic Hernia
Authors: R. P. Shields
Journal: BMJ (1947)

MEDBRTLOURNA 495 ended fatally in' a few months.In the final stages it was found necessary to perform a gastrostomy owing to severe dysphagia.The authors quote Scheuermann, who in 1939 collected from the literature 263 more or less verified cases of polymyositis, and they cons-der it a rare and usually fatal disease.In this connexion the above case might be of even greater interest. Medical Memoranda Case of Strangulated Diaphragmatic HerniaThe following case of strangulated diaphragmatic hernia is of special interest because of the limitation of all symptoms to. the abdomen and the localization of all signs in the chest.
Isolated ultrafiltration in moderate congestive heart failure
Authors: Pier Giuseppe Agostoni, Gian Carlo Marenzi, Mauro Pepi, Elisabetta Doria, Alessandro Salvioni, Giovanni Perego, Glanfranco Lauri, Francesco Giraldi, Sergio Grazi, Maurizio D. Guazzi
Journal: Journal of the American College of Cardiology (1993)
The use of frequency histograms of ultrasonic backscatter amplitudes for detection of atherosclerosis in vitro.
Authors: E Picano, L Landini, F Lattanzi, A Mazzarisi, R Sarnelli, A Distante, A Benassi, A L'Abbate
Journal: Circulation (1986)

This study was designed to determine whether a quantitative analysis of integrated backscatter amplitude distribution is potentially useful in characterizing the atherosclerotic lesion. One hundred measurements (10 X 10 array) were made in fresh aortic regions (2 cm X 2 cm) of nine normal and 19 atherosclerotic arterial walls. A 10 MHz transducer was used. The integrated backscatter distinguished normal from atherosclerotic specimens (-56.7 +/- 4.3 vs -42.5 +/- 8.9 dB, p less than .01). The shape of the integrated backscatter amplitude distribution was analyzed by calculation of skewness and kurtosis of each arterial region. Both skewness values (0.134 +/- 0.325 vs -0.193 +/- 0.491 in normal and atherosclerotic segments, respectively, p = NS) and kurtosis values (0.055 +/- 0.765 vs -0.610 +/- 0.379, p less than .01) discriminated between the two groups. When only the six atherosclerotic specimens with mostly fatty and fibrofatty sites were considered, skewness and kurtosis still distinguished normal from atherosclerotic regions (0.134 +/- 0.325 vs -0.404 +/- 0.232, p less than .05 and 0.055 +/- 0.765 vs -0.558 +/- 0.337, p less than .05, respectively), while integrated backscatter values did not (-56.7 +/- 4.5 vs -52.3 +/- 6.1 dB, p = NS). In conclusion, atherosclerosis may be detected in vitro by the quantitative analysis of integrated backscatter distribution. This variable could also be of help in the identification of less obvious forms of atherosclerotic disease that are not distinguishable on the basis of integrated backscatter amplitude.
RIGHT AND LEFT VENTRICULAR TACHYARRHYTHMIAS AND COMPLEX SYMPTOMATIC REPETITIVE PREMATURE VENTRICULAR COMPLEX. RESULTS OF MAPPING AND RADIOFREQUENCY ABLATION.
Authors: Rafael F. Rabinovich, Andres Bochoeyer, Raul Ferreyra, Ligia Balbuena
Journal: Journal of the American College of Cardiology (2011)
Care for the growing number of elderly people in developing countries needs to be addressed
Authors: D. Dutt
Journal: BMJ (1998)

EDITOR—I strongly agree with Black and Bowman's call for more attention to be paid to the care of elderly people1; the same need exists in developing countries, not just in Britain. As life expectancy increases so too does the number of elderly people living in developing countries. The World Health Organisation estimates that 200 million of the 355 million people older than 65 years are in the developing world.2

In addition to the health issues, which are the same …
Assessing Adverse Drug Experiences
Authors: Judith K. Jones, Raymond L. Herman
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 January 1988Assessing Adverse Drug ExperiencesJUDITH K. JONES, M.D., Ph.D., RAYMOND L. HERMAN, M.A.JUDITH K. JONES, M.D., Ph.D.Search for more papers by this author, RAYMOND L. HERMAN, M.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-1-160_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The Active Permanent Workshop of Imputologists (APWI) was established in 1981 as an informal organization of professionals interested in methods to assess causality of suspected adverse drug reactions. The APWI is not interested in promoting any particular approach or method, but in facilitating a better understanding and communication between those interested in developing better and more reliable assessments of suspected adverse drug reaction causality.We need to gain a better insight into ways the causality or imputability of drugs is established in cases of suspected adverse drug reactions. Physicians using a structured approach (algorithm, decision tables, weighing,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAssessing Causation from Case ReportsAssessing Causality of Case Reports of Suspected Adverse Events 1 January 1988Volume 108, Issue 1Page: 160-161KeywordsAdverse reactionsAlgorithms Issue Published: 1 January 1988 PDF DownloadLoading ...
The logic of moral outrage
Authors: Eric Luis Uhlmann
Journal: Behavioral and Brain Sciences (2012)

Abstract McCullough et al.'s functionalist model of revenge is highly compatible with the person-centered approach to moral judgment, which emphasizes the adaptive manner in which social perceivers derive character information from moral acts. Evidence includes act–person dissociations in which an act is seen as less immoral than a comparison act, yet as a clearer indicator of poor moral character.
The Variability of Young Children's Energy Intake
Authors: Leann L. Birch, Susan L. Johnson, Graciela Andresen, John C. Peters, Marcia C. Schulte
Journal: New England Journal of Medicine (1991)

Research conducted in the 1930s showed that, given nutritious choices, children can select an adequate diet without adult supervision. Paradoxically, children grew well and were healthy despite patterns of intake at individual meals that were unpredictable and highly variable.
Relapsing Polychondritis Diagnosed by Tc-99m MDP Bone Scintigraphy
Authors: YOSHIMASA IMANISHI, YOSHIMI MITOGAWA, MIYOKO TAKIZAWA, SHOUKO KONNO, HIROKO SAMUTA, AYAKO OHSAWA, ATSUYA KAWAGUCHI, MITSUHIRO FUJIKAWA, HIROYUKI SAKAIDA, TOSHIHITO SHINAGAWA, HAJIME YAMASHITA
Journal: Clinical Nuclear Medicine (1999)

Purpose: Relapsing polychondritis is a generalized recurring disease of cartilage that involves joints, trachea, bronchi, laryngeal cartilages, costal cartilages, and cartilages of the ear and nose. It is associated with autoimmune diseases, including Hashimoto disease in some cases. Methods: The authors evaluated a 29-year-old man with relapsing polychondritis who had symptoms and signs of a common cold for 2 months and anterior chest pain near the sternum for 1 month. Results: After the diagnosis, the authors found that the patient had a history of thyroid therapy for hyperthyroidism 15 years before. Tc-99m MDP bone scintigraphy performed to evaluate anterior chest pain showed diffusely increased accumulation of radioactivity in all costocartilages and sternoclavicular joints. Based on that information, relapsing polychondritis was diagnosed. Ga-67 citrate scintigraphy was preformed to determine the optimum biopsy site of the cartilage. The diagnosis was histologically supported by the results of the open biopsy. Conclusions: In this case, Tc-99m MDP bone scintigraphy was useful for diagnosing relapsing polychondritis, and Ga-67 citrate scintigraphy was helpful in determining the biopsy site.
Giant Benign Solitary Fibrous Tumor of the Pleura
Authors: Luis Gorospe
Journal: Clinical Nuclear Medicine (2012)

A chest radiograph revealed a large left lower hemithorax mass in a 48-year-old nonsmoker woman with chronic cough and dyspnea. Whole-body contrast-enhanced PET/CT confirmed a large mass with relatively uniform mild FDG uptake (standardized uptake value = 1.8). No signs of infiltration, pleural effusion, significant regional lymph nodes, or extrathoracic lesions were seen. A presumptive diagnosis of a probable benign solitary fibrous tumor of the pleura (SFTP) was considered. SFTP was confirmed at surgery. Few reported cases have described the PET/CT findings of SFTPs.
Revision of Constitution and Code.
Authors: E. D. Ferguson
Journal: JAMA (1894)

Troy, N. Y., May 4, 1894. <h3>To the Editor:</h3> —The adoption of the amendments to our Constitution, By-laws and Code of Ethics, as proposed by the special committee and printed in theJournalfor April 7, might induce results in some directions not apparent from a cursory examination of the subject—effects it is to be hoped not intended by the gentlemen making the majority report. The changes are in some directions so radical it would seem that probable danger of evil would be appreciated at once, even from a cursory reading of the report, but finding on inquiry that some of my friends failed to notice the<i>trend</i>of the amendments, I concluded that the length of the document, the variety and number of subjects necessarily considered, and the separation of provisions so as not to fully disclose the extent of their relations, might confuse one not on the alert,
Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock
Authors: Dinna N. Cruz, Massimo Antonelli, Roberto Fumagalli, Francesca Foltran, Nicola Brienza, Abele Donati, Vincenzo Malcangi, Flavia Petrini, Giada Volta, Franco M. Bobbio Pallavicini, Federica Rottoli, Francesco Giunta, Claudio Ronco
Journal: JAMA (2009)

Polymyxin B fiber column is a medical device designed to reduce blood endotoxin levels in sepsis. Gram-negative-induced abdominal sepsis is likely associated with high circulating endotoxin. Reducing circulating endotoxin levels with polymyxin B hemoperfusion could potentially improve patient clinical outcomes.To determine whether polymyxin B hemoperfusion added to conventional medical therapy improves clinical outcomes (mean arterial pressure [MAP], vasopressor requirement, oxygenation, organ dysfunction) and mortality compared with conventional therapy alone.A prospective, multicenter, randomized controlled trial (Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis [EUPHAS]) conducted at 10 Italian tertiary care intensive care units between December 2004 and December 2007. Sixty-four patients were enrolled with severe sepsis or septic shock who underwent emergency surgery for intra-abdominal infection.Patients were randomized to either conventional therapy (n=30) or conventional therapy plus 2 sessions of polymyxin B hemoperfusion (n=34).Primary outcome was change in MAP and vasopressor requirement, and secondary outcomes were PaO(2)/FIO(2) (fraction of inspired oxygen) ratio, change in organ dysfunction measured using Sequential Organ Failure Assessment (SOFA) scores, and 28-day mortality.MAP increased (76 to 84 mm Hg; P = .001) and vasopressor requirement decreased (inotropic score, 29.9 to 6.8; P < .001) at 72 hours in the polymyxin B group but not in the conventional therapy group (MAP, 74 to 77 mm Hg; P = .37; inotropic score, 28.6 to 22.4; P = .14). The PaO(2)/FIO(2) ratio increased slightly (235 to 264; P = .049) in the polymyxin B group but not in the conventional therapy group (217 to 228; P = .79). SOFA scores improved in the polymyxin B group but not in the conventional therapy group (change in SOFA, -3.4 vs -0.1; P < .001), and 28-day mortality was 32% (11/34 patients) in the polymyxin B group and 53% (16/30 patients) in the conventional therapy group (unadjusted hazard ratio [HR], 0.43; 95% confidence interval [CI], 0.20-0.94; adjusted HR, 0.36; 95% CI, 0.16-0.80).In this preliminary study, polymyxin B hemoperfusion added to conventional therapy significantly improved hemodynamics and organ dysfunction and reduced 28-day mortality in a targeted population with severe sepsis and/or septic shock from intra-abdominal gram-negative infections.clinicaltrials.gov Identifier: NCT00629382.