Amiodarone and the Liver
Authors: KAREN TORDJMAN
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 March 1985Amiodarone and the LiverKAREN TORDJMAN, M.D., IDO KATZ, M.D., MICHAEL BURSZTYN, M.D., TALMA ROSENTHAL, M.D.KAREN TORDJMAN, M.D.Search for more papers by this author, IDO KATZ, M.D.Search for more papers by this author, MICHAEL BURSZTYN, M.D.Search for more papers by this author, TALMA ROSENTHAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-411_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: First reported by Rotmensch and associates (1), amiodarone pulmonary toxicity is now well known for its life-threatening potential. Due to accumulating information on amiodarone hepatotoxicity, it is regrettable that these authors did not pursue this point, although elevation of hepatic enzymes was the commonest laboratory abnormality encountered in their series (2). We report a case of fatal cirrhosis in a patient treated with amiodarone for over 4 years.A 76-year-old woman had received an average daily dose of 200 mg of amiodarone for recurrent supraventricular tachycardia since December 1979. She was otherwise healthy; results of a physical...References1. ROTMENSCHLIRONTUPILSKILANIADO HMMS. Possible association of pneumonitis with amiodarone therapy [Letter]. Am Heart J. 1980;100:412-3. CrossrefMedlineGoogle Scholar2. ROTMENSCHBELHASSENSWANSON HBD. Steady-state serum amiodarone concentrations: relationships with antiarrhythmic efficacy and toxicity. Ann Intern Med. 1984;101:462-9. LinkGoogle Scholar3. POUCELLIRETONVALENCIA-MAYORAL SJP. Amiodarone-associated phospholipidosis and fibrosis of the liver. Gastroenterology. 1984;86:926-36. MedlineGoogle Scholar4. SIMONMANLEYBRIENARMSTRONG JPJP. Amiodarone hepatotoxicity simulating alcoholic liver disease. N Engl J Med. 1984;311:167-72. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Chaim Sheba Medical Center Tel Hashomer 52621 Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChronic Liver Disease from DrugsLiver and PancreasCausality assessment of liver injury after chronic oral amiodarone intakeLiver and PancreasLow dose amiodarone associated cirrhosisHepatic Cirrhosis Caused by Low-Dose Oral Amiodarone TherapyLiver cirrhosis induced by long-term administration of a daily low dose of amiodarone: A case reportDigestive System 2Effects of short-term and long-term administration of amiodarone on hepatobiliary function in male ratsHépatites à l'amiodarone: diagnostic biologique, histologique, évolution et rôle des facteurs associés. Revue de la littératureAmiodarone-induced liver diseaseA general overview of amiodarone toxicity: Its prevention, detection, and managementHepatotoxicity Associated with Amiodarone TherapyAmiodarone-Induced Liver ToxicityR. Michael Morse, MD, Gregg A. Valenzuela, MD, Todd P. Greenwald, MD, Philip J. Eulie, MD, Robert C. Wesley, MD, Richard W. McCallum, MDAmiodarone HepatotoxicityChronic liver disease after low daily doses of amiodarone 1 March 1985Volume 102, Issue 3Page: 411-412KeywordsCirrhosisEnzymesLiverResearch laboratoriesTachycardiaToxicity Issue Published: 1 March 1985 PDF DownloadLoading ...