tbuckley/cabot-search huggingface dataset:
Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance
Authors: Mitsuhisa Tabata, Tsuyoshi Kadomatsu, Shigetomo Fukuhara, Keishi Miyata, Yasuhiro Ito, Motoyoshi Endo, Takashi Urano, Hui Juan Zhu, Hiroto Tsukano, Hirokazu Tazume, Koichi Kaikita, Kazuya Miyashita, Takao Iwawaki, Michio Shimabukuro, Kazuhiko Sakaguchi, Takaaki Ito, Naomi Nakagata, Tetsuya Yamada, Hideki Katagiri, Masato Kasuga, Yukio Ando, Hisao Ogawa, Naoki Mochizuki, Hiroshi Itoh, Toshio Suda, Yuichi Oike
Journal: Cell Metabolism (2009)
Reduced sarcolemmal expression and function of the NBCe1 isoform of the Na+–HCO3− cotransporter in hypertrophied cardiomyocytes of spontaneously hypertensive rats: role of the renin–angiotensin system
Authors: Alejandro Orlowski, María C. Ciancio, Claudia I. Caldiz, Verónica C. De Giusti, Ernesto A. Aiello
Journal: Cardiovascular Research (2013)

Electroneutral (NBCn1) and electrogenic (NBCe1) isoforms of the Na(+)-HCO3(-) cotransporter (NBC) coexist in the heart. We studied the expression and function of these isoforms in hearts of Wistar and spontaneously hypertensive rats (SHR), elucidating the direct implication of the renin-angiotensin system in the NBC regulation.We used myocytes from Wistar, SHR, losartan-treated SHR (Los-SHR), and Angiotensin II (Ang II)-induced cardiac hypertrophy. We found an overexpression of NBCe1 and NBCn1 proteins in SHR that was prevented in Los-SHR. Hyperkalaemic-induced pHi alkalization was used to study selective activation of NBCe1. Despite the increase in NBCe1 expression, its activity was lower in SHR than in Wistar or Los-SHR. Similar results were found in Ang II-induced hypertrophy. A specific inhibitory antibody against NBCe1 allowed the discrimination between NBCe1 and NBCn1 activity. Whereas in SHR most of the pHi recovery was due to NBCn1 stimulation, in Wistar and Los-SHR the activity of both isoforms was equitable, suggesting that the deteriorated cardiac NBCe1 function observed in SHR is compensated by an enhanced activity of NBCn1. Using the biotin method, we observed greater level of internalized NBCe1 protein in SHR than in the non-hypertophic groups, while with immunofluorescence we localized the protein in endosomes near the nucleus only in SHR.We conclude that Ang II is responsible for the impairment of the NBCe1 in hypertrophied hearts. This is due to retained transporter protein units in early endosomes. Moreover, NBCn1 activity seems to be increased in the hypertrophic myocardium of SHR, compensating impaired function of NBCe1.
Impact of chemotherapy delay on short- and long-term survival in younger and older AML patients: a Danish population-based cohort study
Authors: L S G Ostgård, J M Nørgaard, H Sengeløv, M S Holm, M K Jensen, M Kallenbach, Claus Werenberg Marcher, O J Nielsen, M Nørgaard
Journal: Leukemia (2014)
Diagnosing coronary atherosclerosis using intrinsic fluorescence and reflectance
Authors: George O. Angheloiu, Sweder W.E. van de Poll, Joseph T. Arendt, Markus G. Mueller, Irene Georgakoudi, Abigail Haka, Barry Kuban, Qinggho Zhang, Jonathan Myles, Maryann Fitzmaurice, John R. Kramer, Michael S. Feld
Journal: Journal of the American College of Cardiology (2002)
Ego Defensive Styles and Alexithymia: A Discriminant Validation Study
Authors: Thomas N. Wise, Lee S. Mann, Steven Epstein
Journal: Psychotherapy and Psychosomatics (1991)

Fifty-six mildly depressed psychiatric outpatients were evaluated for alexithymia measured by the Toronto Alexithymia Scale. Each subject also completed a Defensive Style Questionnaire that assessed the maturity of their ego defenses. Alexithymia was strongly associated with immature ego defenses, but not with depression. The data suggests that alexithymia and such primitive defensive operations are separate phenomena. These findings empirically support earlier observations regarding the nature of alexithymia.
Renal Carcinoma and Alpha-2 Globulin
Authors: STANLEY VERMILLION
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 August 1972Renal Carcinoma and Alpha-2 GlobulinSTANLEY VERMILLION, M.D.STANLEY VERMILLION, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-2-324_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The case report by Dr. McPhedran and colleagues (1) describing an "alpha-2 spike" in a case of renal carcinoma was of considerable interest to me. The alpha-2 globulin elevation, in association with renal malignancies, has been recognized for several years; that haptoglobin composes most of this elevation is a more recent observation. Stauffer (2) described a syndrome of nephrogenic hepatic dysfunction in 1961. This syndrome was characterized by an increase in the alkaline phosphatase value, thymol turbidity, sulfobromophthalein retention, and an increase in alpha-2 globulin that was reversible with removal of the tumor. Utz and co-workers described...References1. MCPHEDRANFINCHNEMERSON PSY: Alpha-2 globulin "spike" in renal carcinoma. Ann Intern Med 76:439-441, 1972 LinkGoogle Scholar2. STAUFFER M: Nephrogenic hepatosplenomegaly. Gastroenterology 40:694, 1961 Google Scholar3. UTZWARRENGREGG DMJ: Reversible hepatic dysfunction associated with hypernephroma. Mayo Clin Proc 45:161-169, 1970 MedlineGoogle Scholar4. VERMILLIONMORLOCKBARTHOLOMEW SCL: Nephrogenic hepatic dysfunction: secondary to tunefactive xanthogranulomatous pyelonephritis. Ann Surg 171:130-136, 1970 CrossrefMedlineGoogle Scholar1. NYMAN M: Serum haptoglobin: methodological and clinical studies. Scand J Clin Lab Invest 11 (suppl 39):64, 75, 1959 Google Scholar2. BOTTIGER L: Studies in renal carcinoma. II. Biochemical investigations. Acta Med Scand 167 (fasc 6):455-465, 1960 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCase 40-1974 1 August 1972Volume 77, Issue 2Page: 324-325KeywordsGlobulinsHaptoglobinsPhosphatases ePublished: 1 December 2008 Issue Published: 1 August 1972 PDF downloadLoading ...
The Organ Donor's Doctor: A New Role for the Neurosurgeon
Authors: John Shillito
Journal: New England Journal of Medicine (1969)

IN cities where organ transplantation flourishes, the neurosurgeon is currently enjoying a new kind of attention from some of his colleagues. In addition to his customary role as that unique surgical subspecialist who elects to work in small, deep crannies with sucker and cautery, he now finds himself very much in demand when he is acting as the temporary custodian of young, vigorous patients neurologically destroyed beyond repair, but otherwise physiologically and anatomically intact. As such, the neurosurgeon can be counted on to have patients who are potential sources of many donor organs.Here, then, is a new problem. It . . .
Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis
Authors: Dimitrios-Petrou Bogdanos, Harold Baum, Alessandro Grasso, Manabu Okamoto, Patrice Butler, Yun Ma, Eirini Rigopoulou, Paolo Montalto, Edward T Davies, Andrew K Burroughs, Diego Vergani
Journal: Journal of Hepatology (2003)
Laboratory Request Forms (Menus) That Guide and Teach
Authors: George D. Lundberg
Journal: JAMA (1983)

On page 3076 in this issue, Wong and colleagues present stunning data to show that by merely changing the hospital laboratory test request form, it was possible to diminish orders for triiodothyronine (radioimmunoassay) and thyroid-stimulating hormone tests by approximately two thirds and one third, respectively. This change followed unsuccessful educational efforts by the authors to guide physicians to use these tests appropriately. Over the same time frame, a control group with creatine kinase and lactic dehydrogenase isoenzyme tests showed no significant difference in ordering frequencies. The laboratory request slip is analogous to a restaurant menu. Patrons at a restaurant almost always order from the menu. Only the rare customer will order something that is not on the menu. Likewise, physicians order laboratory tests that are on the menu and only rarely order tests that are not so listed. Furthermore, they order tests with the names and in the groupings that
Carcinomatous Lung Abscess
Authors: Richard J. Wallace, Arthur Cohen, Robert J. Awe, Donald Greenberg, Frank Hadlock, Seung K. Park
Journal: JAMA (1979)

We compared the roentgenographic, bronchoscopic, and cytopathologic findings from 26 patients with carcinomatous lung abscesses (23 of which were within the tumor) with findings from 31 patients with simple lung abscesses. Despite well-described roentgenographic characteristics of the carcinomatous abscess, differentiation from a simple abscess was frequently not possible. Direct visual findings at the time of bronchoscopy were not helpful in the absence of an endobronchial lesion. Using sputums and cytological specimens from a single fiberoptic bronchoscopy, a diagnosis was made by cytopathology on initial hospitalization in 22 (88%) of 25 patients with carcinoma. No false-positive cytological studies were reported in the nonmalignant group despite the frequent presence of inflammation and infection. (<i>JAMA</i>242:521-522, 1979)
Divergence in Expression between Duplicated Genes in Arabidopsis
Authors: Eric W. Ganko, Blake C. Meyers, Todd J. Vision
Journal: Molecular Biology and Evolution (2007)

New genes may arise through tandem duplication, dispersed small-scale duplication, and polyploidy, and patterns of divergence between duplicated genes may vary among these classes. We have examined patterns of gene expression and coding sequence divergence between duplicated genes in Arabidopsis thaliana. Due to the simultaneous origin of polyploidy-derived gene pairs, we can compare covariation in the rates of expression divergence and sequence divergence within this group. Among tandem and dispersed duplicates, much of the divergence in expression profile appears to occur at or shortly after duplication. Contrary to findings from other eukaryotic systems, there is little relationship between expression divergence and synonymous substitutions, whereas there is a strong positive relationship between expression divergence and nonsynonymous substitutions. Because this pattern is pronounced among the polyploidy-derived pairs, we infer that the strength of purifying selection acting on protein sequence and expression pattern is correlated. The polyploidy-derived pairs are somewhat atypical in that they have broader expression patterns and are expressed at higher levels, suggesting differences among polyploidy- and nonpolyploidy-derived duplicates in the types of genes that revert to single copy. Finally, within many of the duplicated pairs, 1 gene is expressed at a higher level across all assayed conditions, which suggests that the subfunctionalization model for duplicate gene preservation provides, at best, only a partial explanation for the patterns of expression divergence between duplicated genes.
Rituximab with chemotherapy improves survival of non-germinal center type untreated diffuse large B-cell lymphoma
Authors: B Saito, E Shiozawa, T Usui, H Nakashima, T Maeda, N Hattori, J Shimozuma, D Adachi, T Yamochi-Onizuka, M Takimoto, T Nakamaki, H Ota, S Tomoyasu
Journal: Leukemia (2007)
Growth‐differentiation factor‐15 improves reclassification for the diagnosis of heart failure with normal ejection fraction in morbid obesity
Authors: Andrea Baessler, Christina Strack, Elena Rousseva, Florian Wagner, Janine Bruxmeier, Martin Schmiedel, Günter Riegger, Claas Lahmann, Thomas Loew, Gerd Schmitz, Marcus Fischer
Journal: European Journal of Heart Failure (2012)
LOOSE BODIES IN THE ELBOW JOINT
Authors: M. S. HENDERSON
Journal: JAMA (1918)

It is not generally recognized that mechanical derangement of the elbow joint is occasionally produced by the presence of osteocartilaginous loose bodies. A locking or impediment to motion in the elbow does not cause the same degree of inconvenience and suffering that a like condition would cause in the knee joint. This fact, and the infrequency with which loose bodies occur in the elbow as compared with the knee, account for the general lack of knowledge concerning their presence in the elbow.  Loose bodies in the elbow joint may be classified into two groups: 1. Pieces of joint surfaces that have been knocked off in fractures. Such fragments are definitely due to trauma; they are often quite large and have to be removed in order that function may be reestablished. The condition will not be considered in this article. 2. Bodies not definitely due to trauma, found in numbers varying
Tragedy and Insomnia
Authors: David P. White
Journal: New England Journal of Medicine (2001)

In this issue of the Journal, Lavie points out the high frequency of sleep disturbances, primarily insomnia and nightmares, that occur after local or distant disasters.1 This observation is supported by the recent article on stress reactions after the September 11 terrorist attacks.2 Schuster et al. reported that 11 percent of randomly selected adults in the United States have had “trouble falling or staying asleep” since the attacks.2 Lavie also stresses that such sleep disturbances may precede or even predict the development of more sustained sleep disturbances, psychiatric disorders, or physical symptoms. The question therefore becomes whether sleep disturbances related . . .
Medical Schools in Japan
Authors: Lester C. Mark
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The INTERNATIONAL COMMENTS section (<b>204</b>:281, 1968), which contains an otherwise accurate and excellent account of medical progress in Japan, reports the existence of only ten medical schools in all of Japan. Probably the statement was intended to refer only to the city of Tokyo, whose medical schools now number, not ten, but 11 (those of Jikeikai, Juntendo, Keio, Nippon, Showa, Toho, Tokyo, and Tokyo Medical and Dental Universities, as well as Nippon, Tokyo, and Tokyo Women's Medical Colleges). Actually, there are now at least 46 medical schools in Japan. Of these, 21 are components of socalled national universities, controlled and supported by the Ministry of Education in Tokyo; another 12, also public, are under the jurisdiction of municipalities, prefectures, or (in the case of Sapporo Medical College) Japan's one province, Hokkaido; the remaining 13 are privately operated (Zenkoku Gakko Soran [The Grand Review of All Schools
Breast feeding in Scotland
Authors: A. E Ferguson, D. M Tappin, R. W A Girdwood, R. Kennedy, F. Cockburn
Journal: BMJ (1994)

<h3>abstract</h3> <b>Objective</b>: To measure the prevalence of breast feeding and to examine the value of using information collected on Guthrie cards (used for detecting inherited metabolic disease and hypothyroidism when newborn infants are 7 days old) to calculate this prevalence. <b>Design</b>: Analysis, by geographical area and maternity unit, of information on breast feeding collected on Guthrie cards for 131759 babies born in 1990 and 1991, and comparison with prevalences from other sources. <b>Setting</b>: Scotland. <b>Results</b>: Of the 131 759 babies, only 46 949 (35.6%) were breast feeding on day 7. The prevalence of breast feeding ranged from 59.1% (376/636) in Shetland to 21.1% (1836/8719) in Lanarkshire and &lt; 8% in some postcode districts of cities. Analysis of the data by hospital of birth showed that the prevalence ranged from 51.2% (2701/5275) to 16.4% (507/3090). Conclusion--The prevalence of breast feeding in Scotland is low and varies among areas and maternity units. Intervention to increase this prevalence is essential, and information collected on Guthrie cards is a useful indication of mothers9 intentions to breast feed.
Oral versus intravenous corticosteroids in children hospitalized with asthma
Authors: Jack M. Becker, Anjali Arora, Richard J. Scarfone, Nancy D. Spector, Mary Elizabeth Fontana-Penn, Edward Gracely, Mark D. Joffe, Donald P. Goldsmith, J.Jeffrey Malatack
Journal: Journal of Allergy and Clinical Immunology (1999)
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.
Authors: H Xu, J A Gonzalo, Y St Pierre, I R Williams, T S Kupper, R S Cotran, T A Springer, J C Gutierrez-Ramos
Journal: The Journal of Experimental Medicine (1994)

Intercellular adhesion molecule 1 (ICAM-1) is one of three immunoglobulin superfamily members that bind to the integrins lymphocyte function associated 1 (LFA-1) and Mac-1 on leukocytes. We have generated mice that are genetically and functionally deficient in ICAM-1. These mice have elevated numbers of circulating neutrophils and lymphocytes, as well as diminished allogeneic T cell responses and delayed type hypersensitivity. Mutant mice are resistant to lethal effects of high doses of endotoxin (lipopolysaccharide [LPS]), and this correlates with a significant decrease in neutrophil infiltration in the liver. Production of inflammatory cytokines such as tumor necrosis factor alpha or interleukin 1 is normal in ICAM-1-deficient mice, and thus protection appears to be related to a diminution in critical leukocyte-endothelial interactions. After sensitization with D-galactosamine (D-Gal), ICAM-1-deficient mice are resistant to the lethal effect of low doses of exotoxin (Staphylococcus aureus enterotoxin B [SEB]), which has been shown to mediate its toxic effects via the activation of specific T cells. In this model, ICAM-1-mediated protection against SEB lethality correlates with a decrease in the systemic release of inflammatory cytokines, as well as with prevention of extensive hepatocyte necrosis and hemorrhage. ICAM-1-deficient mice sensitized with D-Gal, however, are not protected from lethality when challenged with low doses of endotoxin (LPS). These studies show that the different contribution of ICAM-1 in the activation of either T cells or macrophages is decisive for the fatal outcome of the shock in these two models. This work suggests that anti-ICAM-1 therapy may be beneficial in both gram-positive and -negative septic shock, either by reducing T cell activation or by diminishing neutrophil infiltration.
Response and Resistance to Interferons and Interacting Cytokines
Authors: E. C. Borden, J. Waalen, R. Schreiber, B. Williams
Journal: JNCI Journal of the National Cancer Institute (1995)

Interferons (IFNs) were the first cytokines cloned and expressed.For the past 15 years, their actions as cellular modulators, in addition to their antiviral activity, have been more broadly defined.Signal transduction pathways, dissected by use of IFN mutant cell lines, have proven to be common pathways for many cytokines.Effects of IFNs in influencing differentiation, function of immune effector cell types, and role in antigen presentation and processing may be critical in therapeutic impact in malignancies such as chronic myelogenous leukemia, viral diseases such as hepatitis B and hepatitis C, and diseases of immunopathologic origin such as multiple sclerosis.The last 2 years have been a period of particularly rapid progress in defining molecular, cellular, and clinical effects of IFNs.Because of this progress, a meeting sponsored by Serono Symposia, USA, on factors influencing cellular and clinical response and resistance was held June 23-26, 1994, in Litchfield Park, Ariz.Participants in the meeting defined pathways that regulate gene expression including receptor function, tyrosine kinases, signal transduction pathways, and transcriptional regulation as well as resistance mechanisms to antiviral effects.Data on the functional effects of the protein products of induced genes were presented, as were the new findings on the impact of IFNs on immunologic function in cellular systems, mutant mice, and clinical settings.The meeting concluded with examples of various approaches that may be used to overcome cellular resistance to IFNs in malignancy.
Hepatitis B Transmitted by a Human Bite
Authors: Michael B. MacQuarrie
Journal: JAMA (1974)

HEPATITIS B, formerly termed serum hepatitis, is transmitted by inoculation of blood or blood products containing hepatitis B antigen (HB Ag). Recent experimental and epidemiologic evidence suggests that disease can be transmitted by person-to-person contact (sexual, blood-oral) and by the fecal-oral route.<sup>1,2</sup>In some cases of HB Ag-positive hepatitis, a history of inoculation or transfusion of blood or blood products is lacking, and evidence for other routes of infection has been sought. Hepatitis B antigen has been demonstrated by various methods in the urine, feces,<sup>3</sup>saliva,<sup>4</sup>and semen<sup>5</sup>with and without evidence of trace amounts of blood. <h3>Report of a Case</h3> On Oct 18, 1972, a 52-year-old woman reported to a clinic complaining of nausea, weakness, loss of appetite for one week, dark urine, and jaundice. Liver function studies confirmed the diagnosis of hepatitis. She had not eaten raw shellfish, had never had a blood transfusion,
Abstract 127: miR-141 confers anoikis resistance of ovarian cancer cells by targeting KLF12
Authors: Sze Ling Mak
Journal: Cancer Research (2012)

Abstract Anoikis resistance is one of the fundamental capacities of metastatic cancer cells to survive during invasion and dissemination. Emerging evidences have documented that deregulation of miRNAs have been associated with different aspects of tumorigenesis. In this study, we aimed to identify putative miRNA candidates that govern this process during metastasis of ovarian cancers. Using miRCURY™ LNA Array profiling (1264 miRNAs) analyze on two categories of ovarian cancer cell lines: high and low anchorage-independent growth ability. We firstly sorted out a list of 9 miRNAs which were upregulated and associated with high anchorage-independent growth ability in ovarian cancer cells. Amongst these candidates, miR-141 retained the strongest anchorage-independent growth ability examined by soft agar assay. Further real-time Q-PCR analysis found that miR-141 was frequently upregulated in ovarian cancer cell lines (n = 6) and clinical samples (n = 49) as compared with normal ovaries (n = 12). Functional studies showed that enforced expression of miR-141 increased both number and size of colonies formed in soft agar assay, and cell growth in focus formation assay. Moreover, miR-141 could enhance cell survival and proliferation in ovarian cancer cells in low serum media. Conversely, inhibition of miR-141 expression by miR-141 inhibitor could abrogate the above tumorigenic functions in ovarian cancer cells. On the other hand, by computational miRNA target prediction and pMIR-REPORT miRNA luciferase assay, we identified a tumor suppressor, Krüppel-related zinc finger protein AP-2rep (KLF12), was post-transcriptionally downregulated by miR-141. Previous studies have documented that KLF12 is a tumor suppressor in inhibiting AP2-induced tumorigenicity including anoikis resistance. Indeed, our biochemical analyses using luciferase reporter assays in combination with mutational analyses and Western blotting confirmed that miR-141 specifically targeting KLF 3′UTR and its expression. Taken together, our findings suggest that miR-141 is an oncogene that can enhance anoikis resistance in ovarian cancer cells through downregulation of KLF12. However, further investigation in delineating molecular mechanism of miR-141 and KLF12 in mediating ovarian cancer oncogenesis is warranted. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 127. doi:1538-7445.AM2012-127