tbuckley/cabot-search huggingface dataset:
Evidence for reduced fibrinolytic activity in unstable angina at rest. Clinical, biochemical, and angiographic correlates.
Authors: A Zalewski, Y Shi, D Nardone, B Bravette, P Weinstock, D Fischman, P Wilson, S Goldberg, D C Levin, T D Bjornsson
Journal: Circulation (1991)

BACKGROUND The goal of this study was to evaluate the role of the fibrinolytic system in patients with unstable angina at rest associated with transient electrocardiographic changes. METHODS AND RESULTS Tissue plasminogen activator activity in plasma was comparable among patients with unstable angina (n = 17), patients with stable exertional angina (n = 10), and control patients with normal coronary arteriograms (n = 8). In contrast, plasminogen activator inhibitor-1 (PAI-1) activity in plasma was elevated in the unstable angina group (21.67 +/- 9.52 AU/ml) as compared with either the stable angina group (12.01 +/- 7.06 AU/ml, p less than 0.02) or the controls (12.49 +/- 8.54 AU/ml, p less than 0.02). Coronary angiography performed within 24 hours after the last anginal episode showed a similar extent of coronary artery disease in the unstable and stable angina groups. However, intracoronary thrombi were observed in eight patients in the unstable angina group while no thrombus was noted in the stable angina group (chi 2 = 7.22, p less than 0.01). CONCLUSIONS We conclude that patients with unstable angina at rest have a reduced fibrinolytic activity and an increased incidence of intracoronary thrombi. It is postulated that elevated PAI-1 activity in the presence of coronary arterial wall injury may be an important factor leading to the development of acute coronary syndromes.
Prediction of liver histological lesions with biochemical markers in patients with chronic hepatitis B
Authors: Robert P. Myers, Marie-Hélène Tainturier, Vlad Ratziu, Annie Piton, Vincent Thibault, Françoise Imbert-Bismut, Djamila Messous, Frederic Charlotte, Vincent Di Martino, Yves Benhamou, Thierry Poynard
Journal: Journal of Hepatology (2003)
Experts, Organizations Debate Whether Women in Labor Can Safely Eat and Drink
Authors: Mike Mitka
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The integration profile of EIAV-based vectors
Authors: Caroline V. Hacker, Conrad A. Vink, Theresa W. Wardell, Sheena Lee, Peter Treasure, Susan M. Kingsman, Kyriacos A. Mitrophanous, James E. Miskin
Journal: Molecular Therapy (2006)

Lentiviral vectors based on equine infectious anemia virus (EIAV) stably integrate into dividing and nondividing cells such as neurons, conferring long-term expression of their transgene. The integration profile of an EIAV vector was analyzed in dividing HEK293T cells, alongside an HIV-1 vector as a control, and compared to a random dataset generated in silico. A multivariate regression model was generated and the influence of the following parameters on integration site selection determined: (a) within/not within a gene, (b) GC content within 20 kb, (c) within 10 kb of a CpG island, (d) gene density within a 2-Mb window, and (e) chromosome number. The majority of the EIAV integration sites (68%; n = 458) and HIV-1 integration sites (72%; n = 162) were within a gene, and both vectors favored AT-rich regions. Sites within genes were examined using a second model to determine the influence of the gene-specific parameters, gene region, and transcriptional activity. Both EIAV and HIV-1 vectors preferentially integrated within active genes. Unlike the gammaretrovirus MLV, EIAV and HIV-1 vectors do not integrate preferentially into the promoter region or the 5' end of the transcription unit.
THE IMPACT OF CYP2C19&amp;ast;2 POLYMORPHISM ON ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH CORONARY ARTERY DISEASE RECEIVING CLOPIDOGREL
Authors: Marina Zaromitidou, Gerasimos Siasos, Dimitris Tousoulis, Stamatios Kioufis, Evangelos Oikonomou, Konstantinos Maniatis, Antigoni Miliou, Christina Kollia, Stavroula Michalea, Konstantinos Zisimos, Eleni Kokkou, Athanasios G. Papavassiliou, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2012)
Corrigendum to “Efficient delivery of a Bcl2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor targeted liposomes” [Journal of Controlled Release 112 (2006) 199–207]
Authors: Shih-Jiuan Chiu, Shujun Liu, Danilo Perrotti, Guido Marcucci, Robert J. Lee
Journal: Journal of Controlled Release (2006)
Quality of Life of Patients with Newly Diagnosed Poor Prognosis M1 Prostate Cancer Undergoing Orchiectomy without or with Mitomycin C
Authors: S.D. Foss&aring;, D. Curran, N.K. Aaronson, F. Keuppens, J. Kliment, M.R.G. Robinson, T.M. DeReijke, J. Hetherington, P.J.M. Kil, L.A. Rea
Journal: European Urology (2000)
Measurement of IgE antibodies against purified grass‐pollen allergens (Phl p 1, 2, 3, 4, 5, 6, 7, 11, and 12) in sera of patients allergic to grass pollen
Authors: R. E. Rossi, G. Monasterolo, S. Monasterolo
Journal: Allergy (2001)

Current allergy diagnosis is performed with allergen extracts which contain a variety of allergenic and nonallergenic components. The availability of highly purified and well-characterized allergen molecules seems to be an advantage of component-based diagnosis.With the immunoenzymatic CAP FEIA System, we measured specific IgE levels to the recombinant allergens rPhl p 1, rPhl p 2, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, rPhl p 12, and native Phl p 4 in 77 sera of patients allergic to grass pollen, in order to evaluate the IgE-binding frequency to these purified grass-pollen allergens and their relationship to rBet v 4, rBet v 2, and other allergens.The frequency of sensitization was as follows: rPhl p 1=93.5%; rPhl p 2=67.5%; rPhl p 5=72.7%; rPhl p 6=68.8%; rPhl p 7=7.8%; rPhl p 11=53.2%; rPhl p 12=35.1%; and native Phl p 4=88.3%. As expected, rPhl p 7 and rPhl p 12 had a very good correlation (Spearman's r) with Bet v 4 (r=0.95%, P<0.05) and rBet v 2 (r=0.99, P<0.05), respectively. Good correlations of rPhl p 12 with papain (r=0.93, P<0.05), latex (r=0.92, P<0.05), and bromelain (r=0.86, P<0.05) were found. Highly variable individual sensitization patterns were observed.A new clinical approach has allowed the determination of specific allergograms for the different patients and may therefore be of great importance for more specific diagnosis. The use of component-resolved diagnostics may be useful to evaluate the allergen content of an extract for immunotherapy by monitoring patient's IgE and IgG directed to relevant allergens.
Human Oil in Treatment of Adherent Scars
Authors: C. P. G. Wakeley
Journal: BMJ (1938)

c.mm., with a differential count showing 65 per cent.lymphocytes and 28 per cent.polymorphonuclears.(e) The ervythr-ocyte sedimentation rate is shown to be slightly retarded or normal in almost all uncomplicated cases of whooping-cough in the early stages, with a slight increase in the later stages of the illness.I wish to thank Dr. A. Joe, medical superintendent of the Edinburgh City Hospital, formerly of the North-Western Hospital.for his advice and helpful criticism
Effect of a collector bag for measurement of postpartum blood loss after vaginal delivery: cluster randomised trial in 13 European countries
Authors: W.-H. Zhang, C. Deneux-Tharaux, P. Brocklehurst, E. Juszczak, M. Joslin, S. Alexander
Journal: BMJ (2010)

<b>Objective</b> To evaluate the effectiveness of the systematic use of a transparent plastic collector bag to measure postpartum blood loss after vaginal delivery in reducing the incidence of severe postpartum haemorrhage. <b>Design</b> Cluster randomised trial. <b>Setting</b> 13 European countries. <b>Participants</b> 78 maternity units and 25 381 women who had a vaginal delivery. <b>Interventions</b> Maternity units were randomly assigned to systematic use of a collector bag (intervention group) or to continue to visually assess postpartum blood loss after vaginal delivery (control group). <b>Main outcome measures</b> The primary outcome was the incidence of severe postpartum haemorrhage in vaginal deliveries, defined as a composite of one or more of blood transfusion, intravenous plasma expansion, arterial embolisation, surgical procedure, admission to an intensive care unit, treatment with recombinant factor VII, and death. <b>Results</b> Severe postpartum haemorrhage occurred in 189 of 11 037 of vaginal deliveries (1.71%) in the intervention group compared with 295 of 14 344 in the control group (2.06%). The difference was not statistically significant either in individual level analysis (adjusted odds ratio 0.82, 95% confidence interval 0.26 to 2.53) or in cluster level analysis (difference in weighted mean rate adjusted for baseline rate 0.16%, 95% confidence interval −0.69% to 1.02%). <b>Conclusion</b> Compared with visual estimation of postpartum blood loss the use of a collector bag after vaginal delivery did not reduce the rate of severe postpartum haemorrhage. <b>Trial registration</b> Current Controlled Trials ISRCTN66197422.
Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill. Canadian Critical Care Trials Group
Authors: D. J. Cook
Journal: JAMA (1995)

To examine the attitudes of health care workers regarding the withdrawal of life support.Cross-sectional survey.Attending staff, house staff, and intensive care unit (ICU) nurses in 37 Canadian university-affiliated hospitals.Health care workers' ratings of the importance of 17 factors considered in the decision to withdraw life support, and their ratings of five levels of care ranging from comfort measures to intensive care in two of 12 different clinical scenarios.We surveyed 1361 respondents (149 of 167 potentially eligible ICU attending staff, 142 of 173 ICU house staff, and 1070 of 1455 ICU nurses, with response rates of 89%, 82% and 74%, respectively). The most important factors were likelihood of surviving the current episode, likelihood of long-term survival, premorbid cognitive function, and age of the patient. In choosing the level of care for the patient scenarios, the same option was chosen by more than 50% of respondents in only one of 12 scenarios; opposite extremes of care were chosen by more than 10% of the respondents in eight of 12 scenarios. Respondent characteristics affecting choices included the number of years since graduation, the city and province in which they worked, the number of beds in their ICU, and their assessment of the likelihood that they would withdraw life support in comparison with their colleagues (P < .001 for all comparisons).While ICU health care workers consistently identify a number of patient factors as important in decisions to withdraw care, there is extreme variability, which may be explained in part by the values of individual health care providers.
MicroRNA Expression Patterns to Differentiate Pancreatic Adenocarcinoma From Normal Pancreas and Chronic Pancreatitis
Authors: Mark Bloomston, Wendy L. Frankel, Fabio Petrocca, Stefano Volinia, Hansjuerg Alder, John P. Hagan, Chang-Gong Liu, Darshna Bhatt, Cristian Taccioli, Carlo M. Croce
Journal: JAMA (2007)

While global microRNA (miRNA) expression patterns of many embryologic, physiologic, and oncogenic processes have been described, description of the role of miRNAs in ductal adenocarcinoma of the pancreas is lacking.To define the expression pattern of miRNAs in pancreatic cancer and compare it with those of normal pancreas and chronic pancreatitis.Specimens were obtained at a National Cancer Institute-designated comprehensive cancer center from patients with ductal adenocarcinoma of the pancreas (n = 65) or chronic pancreatitis (n = 42) (January 2000-December 2005). All patients underwent curative pancreatectomy; those with pancreatic cancer were chemotherapy-naive. RNA harvested from resected pancreatic cancers and matched benign adjacent pancreatic tissue as well as from chronic pancreatitis specimens was hybridized to miRNA microarrays.Identification of differentially expressed miRNAs that could differentiate pancreatic cancer from normal pancreas, chronic pancreatitis, or both, as well as a pattern of miRNA expression predictive of long-term (>24 months) survival. Significance of Analysis of Microarrays and Prediction of Analysis of Microarrays were undertaken to identify miRNAs predictive of tissue type and prognosis. P values were calculated by t test, adjusted for multiple testing. Kaplan-Meier survival curves were constructed using mean miRNA expression (high vs low) as threshold and compared by log-rank analysis.Twenty-one miRNAs with increased expression and 4 with decreased expression were identified that correctly differentiated pancreatic cancer from benign pancreatic tissue in 90% of samples by cross validation. Fifteen overexpressed and 8 underexpressed miRNAs differentiated pancreatic cancer from chronic pancreatitis with 93% accuracy. A subgroup of 6 miRNAs was able to distinguish long-term survivors with node-positive disease from those dying within 24 months. Finally, high expression of miR-196a-2 was found to predict poor survival (median, 14.3 months [95% confidence interval, 12.4-16.2] vs 26.5 months [95% confidence interval, 23.4-29.6]; P = .009).Pancreatic cancer may have a distinct miRNA expression pattern that may differentiate it from normal pancreas and chronic pancreatitis. miRNA expression patterns may be able to distinguish between long- and short-term survivors, but these findings need to be validated in other study populations.
A STREPTOCOCCAL ENZYME THAT ACTS SPECIFICALLY UPON DIPHOSPHOPYRIDINE NUCLEOTIDE: CHARACTERIZATION OF THE ENZYME AND ITS SEPARATION FROM STREPTOLYSIN O
Authors: Arthur S. Carlson, Aaron Kellner, Alan W. Bernheimer, Elizabeth B. Freeman
Journal: The Journal of Experimental Medicine (1957)

All enzyme that destroys DPN has been found in fractionated and highly concentrated streptococcal preparations that also contain streptolysin O. The enzyme-streptococcal DPNase-was shown by electrophoretic separation and by other means to be distinct from streptolysin O. It is non-dialyzable, heat-labile, and has optimal activity in the pH range 7.2 to 7.8. The enzyme has a high degree of specificity for DPN, which it splits at the nicotinamide-ribose linkage.
Practice-Based Research Networks Answer Primary Care Questions
Authors: Paul A. Nutting
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for and Treatment of Suicide Risk Relevant to Primary Care: A Systematic Review for the U.S. Preventive Services Task Force
Authors: Elizabeth O'Connor, Bradley N. Gaynes, Brittany U. Burda, Clara Soh, Evelyn P. Whitlock
Journal: Annals of Internal Medicine (2013)

Background: In 2009, suicide accounted for 36 897 deaths in the United States. Purpose: To review the accuracy of screening instruments and the efficacy and safety of screening for and treatment of suicide risk in populations and settings relevant to primary care. Data Sources: Citations from MEDLINE, PsycINFO, the Cochrane Central Register of Controlled Trials, and CINAHL (2002 to 17 July 2012); gray literature; and a surveillance search of MEDLINE for additional screening trials (July to December 2012). Study Selection: Fair- or good-quality English-language studies that assessed the accuracy of screening instruments in primary care or similar populations and trials of suicide prevention interventions in primary or mental health care settings. Data Extraction: One investigator abstracted data; a second checked the abstraction. Two investigators rated study quality. Data Synthesis: Evidence was insufficient to determine the benefits of screening in primary care populations; very limited evidence identified no serious harms. Minimal evidence suggested that screening tools can identify some adults at increased risk for suicide in primary care, but accuracy was lower in studies of older adults. Minimal evidence limited to high-risk populations suggested poor performance of screening instruments in adolescents. Trial evidence showed that psychotherapy reduced suicide attempts in high-risk adults but not adolescents. Most trials were insufficiently powered to detect effects on deaths. Limitation: Treatment evidence was derived from high-risk rather than screening-detected populations. Evidence relevant to adolescents, older adults, and racial or ethnic minorities was limited. Conclusion: Primary care–feasible screening tools might help to identify some adults at increased risk for suicide but have limited ability to detect suicide risk in adolescents. Psychotherapy may reduce suicide attempts in some high-risk adults, but effective interventions for high-risk adolescents are not yet proven. Primary Funding Source: Agency for Healthcare Research and Quality.
THE EFFECT OF INTERMITTENT STRETCHING ON MUSCLES AND NERVES AFTER NERVE SEVERANCE
Authors: J. N. Langley
Journal: BMJ (1918)

TARYLtf 14SH1 jam, sweet foods, clhocolate, and drinkls containing imuclh sugar, such as herb beer, sweet wines, aud combinations of sugar ancl alcolhol.Tlley would tllereby be lhelpina the Food Controller, as well as doing somletlhing to diminiisl their own risk of diabetes.Alcohol, and espeeially combinations of alcolhol and sugar, if they can still be obtained, slhould be very limited in the case of those who have inuch mental strain, anxiety, or worry.The regulations now in force will clleck any excess for most people.
Fibrinolytic response during exercise and epinephrine infusion in the same subjects
Authors: Wayne L. Chandler, Richard C. Veith, Gilbert W. Fellingham, Wayne C. Levy, Robert S. Schwartz, Manuel D. Cerqueira, Steven E. Kahn, Valerie G. Larson, Kevin C. Cain, James C. Beard, Itamar B. Abrass, John R. Stratton
Journal: Journal of the American College of Cardiology (1992)
Correction: Error in "Noninvasive Assessment of Myocardial Function"
Authors: GOPAL DAS
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 May 1980Correction: Error in "Noninvasive Assessment of Myocardial Function"GOPAL DAS, M.D.GOPAL DAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-5-723_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I write to point out an error in a statement made by Dr. J. K. Perloff (1) in "Noninvasive Assessment of Myocardial Function." Using the left ventricular end-diastolic and end-systolic diameters measured from M-mode echocardiogram, he states "Stroke volume (SV) is the difference between left ventricular end-diastolic (EDV) and end-systolic volumes (ESV): SV = EDV - ESV, derived from [left ventricular end-diastolic dimensions]3- [left ventricular end-systolic dimensions]3, or preferably [Δ left ventricular dimensions]3." Mathematically, assigning A to end-diastolic and B to end-systolic diameter, it implies that A3- B3= (A - B)3. Algebraically, (A -...Reference1. PERLOFF J. M-mode echocardiography, pp. 78-81. In: SHINE KI, moderator. Noninvasive assessment of myocardial function. Ann Intern Med. 1980;92:78-90. MedlineGoogle Scholar1. PERLOFF J. M-mode echocardiography, pp. 78-81. In: SHINE KI, moderator. Noninvasive assessment of myocardial function. Ann Intern Med. 1980;92:78-90. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1980Volume 92, Issue 5Page: 723-723KeywordsStroke Issue Published: 1 May 1980 PDF downloadLoading ...
Use of GLP-1 Receptor Agonists in Prader-Willi Syndrome: Report of Six Cases
Authors: Danilo Fintini, Graziano Grugni, Claudia Brufani, Sarah Bocchini, Marco Cappa, Antonino Crinò
Journal: Diabetes Care (2014)

A high incidence of glucose metabolism alterations (impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes) has been observed in Prader-Willi syndrome (PWS) (7–40%), particularly after pubertal age and in obese subjects (1). Glucagon-like peptide 1 (GLP-1) receptor agonist (exenatide) and analog (liraglutide) are the new drugs recently introduced for type 2 diabetes that simultaneously reduce appetite and body weight, and their beneficial effects have been reported only in few cases with PWS (2–5).

We report, for the first time, the effects of long-term liraglutide or exenatide treatment in six genetically confirmed (3 deletion and 3 uniparental disomy of chromosome 15) (UPD) adult PWS patients (3 males, aged 20.7–37.7 years; all but one obese, BMI 28–57.2 kg/m2) never treated with growth hormone, affected by type 2 diabetes. All patients were treated at least …