Long-Term Follow-up of Voluntary Ingestion of <i>Helicobacter pylori</i>
Authors: Arthur J. Morris, M. Rafiq Ali, Gordon I. Nicholson, Guillermo I. Perez-Perez, Martin J. Blaser
Journal: Annals of Internal Medicine (1991)

Brief Reports15 April 1991Long-Term Follow-up of Voluntary Ingestion of Helicobacter pyloriArthur J. Morris, BSc, MBChB, M. Rafiq Ali, MBChB, Gordon I. Nicholson, MBChB, Guillermo I. Perez-Perez, DSc, Martin J. Blaser, MDArthur J. Morris, BSc, MBChB, M. Rafiq Ali, MBChB, Gordon I. Nicholson, MBChB, Guillermo I. Perez-Perez, DSc, Martin J. Blaser, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-8-662 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1985, Barry Marshall reported his ingestion ofHelicobacter pylori(previously known asCampylobacter pylori[1]). He developed an acute, but self-limited, histologic gastritis (2). In 1987, Morris and Nicholson (3) reported the case of another volunteer who ingestedH. pylori. Although the volunteer had symptoms for only 10 days, both the infection and histologic gastritis persisted until day 67 when 1 month of treatment with bismuth subsalicylate was begun. A biopsy specimen obtained 1 week after completing therapy, on day 103, showed the apparent eradication ofH. pyloriand the almost complete resolution of histologic gastritis (3). We report...References1. Goodwin C, Armstrong J, and Chilvers T. Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and Helicobacter mustelae comb. nov. respectively. Int J Syst Bacteriol. 1989;39:397-405. CrossrefGoogle Scholar2. Marshall B, Armstrong J, McGechie D, and Glancy R. Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust. 1985;142:436-9. CrossrefMedlineGoogle Scholar3. Morris A and Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting pH. Am J Gastroenterol. 1987;82:192-9. MedlineGoogle Scholar4. Morris A, Ali M, Brown P, Lane M, and Patton K. Campylobacter pylori infection in biopsy specimens of gastric antrum: laboratory diagnosis and estimation of sampling error. J Clin Pathol. 1989;42:727-32. CrossrefMedlineGoogle Scholar5. Perez-Perez G, Dworkin B, Chodos J, and Blaser M. Campylobacter pylori antibodies in humans. Ann Intern Med. 1988;109:11-7. LinkGoogle Scholar6. Perez-Perez G and Blaser M. Conservation and diversity of Campylobacter pyloridis major antigens. Infect Immun. 1987;55:1256-63. CrossrefMedlineGoogle Scholar7. Langenberg W, Rauws E, Widjojokusumo A, Tytgat G, and Zanen H. Identification of Campylobacter pyloridis isolates by restriction endonuclease DNA analysis. J Clin Microbiol. 1986;24:414-7. CrossrefMedlineGoogle Scholar8. Dooley C, Cohen H, and Fitzgibbons P. Prevalence of Helicobacter pylori infection in histologic gastritis in asymptomatic persons. N Engl J Med. 1989;321:1562-6. CrossrefMedlineGoogle Scholar9. Rauws E, Langenberg W, Houthoff H, Zanen H, and Tytgat G. Campylobacter pyloridis—associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gastroenterology. 1988;94:33-40. CrossrefMedlineGoogle Scholar10. George L, Borody T, and Andrews P. Cure of duodenal ulceration after eradication of Helicobacter pylori. Med J Aust. 1990;153:145-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Arthur J. Morris, BSc, MBChB; M. Rafiq Ali, MBChB; Gordon I. Nicholson, MBChB; Guillermo I. Perez-Perez, DSc; Martin J. Blaser, MDFrom the Duke University Medical Center, Durham, North Carolina; Middlemore Hospital and Auckland Hospital, Auckland, New Zealand; and Vanderbilt University Medical Center, Nashville, Tennessee. For current author addresses, see end of text. 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