Steroid Therapy in Patients with Polymyositis and Dermatomyositis
Authors: DONALD W. MULDER
Journal: Annals of Internal Medicine (1963)

Article1 June 1963Steroid Therapy in Patients with Polymyositis and DermatomyositisDONALD W. MULDER, M.D., R. K. WINKELMANN, M.D., EDWARD H. LAMBERT, M.D., G. ROY DIESSNER, M.D., FRANK M. HOWARD JR., M.D.DONALD W. MULDER, M.D.Search for more papers by this author, R. K. WINKELMANN, M.D.Search for more papers by this author, EDWARD H. LAMBERT, M.D.Search for more papers by this author, G. ROY DIESSNER, M.D.Search for more papers by this author, FRANK M. HOWARD JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-6-969 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPolymyositis and dermatomyositis cause weakness and atrophy (1, 2) of muscle. Eaton in a classic paper delineated the clinical syndrome of polymyositis and noted "that the muscular component in the clinical entity polymyositis and dermatomyositis is identical." Within weeks to months patients with this disorder develop a symmetric weakness most marked in the proximal muscles (3). In most patients the disease can be suspected on the basis of the patient's history and clinical examination, and the diagnosis can be corroborated by muscle biopsy, electromyographic findings, and studies of the enzymes in the blood.The clinical course of polymyositis, unlike that...References1. EATON LM: The perspective of neurology with regard to polymyositis: a study of 41 cases. Neurology 4: 245, 1954. CrossrefMedlineGoogle Scholar2. MULLERWINKELMANNBRUNSTING SARKLA: Calcinosis in dermatomyositis: observations on course of disease in children and adults. Arch. Derm. (Chicago) 79: 669, 1959. CrossrefGoogle Scholar3. WALTONADAMS JNRD: Polymyositis, E. & S. Livingstone, Ltd., Edinburgh, 1958, 269 pp. Google Scholar4. SHYMCEACHERN GMD: The clinical features and response to cortisone of menopausal muscular dystrophy. J. Neurol. Neurosurg. Psychiat. 14: 101, 1951. CrossrefMedlineGoogle Scholar5. BARWICKWALTON DDJN: The clinical picture and treatment of polymyositis. Int. J. Neurol. 1: 342, 1960. MedlineGoogle Scholar6. CHRISTIANSONBRUNSTINGPERRY HBLAHO: Dermatomyositis, unusual features, complications and treatment. Arch. Derm. (Chicago) 74: 581, 1956. CrossrefGoogle Scholar7. ROWLAND LP: Muscular dystrophies, polymyositis and other myopathies. J. Chron. Dis. 8: 510, 1958. CrossrefMedlineGoogle Scholar8. SHY GM: The late onset myopathy: a clinicopathologic study of 131 patients. World Neurol. 3: 149, 1962. MedlineGoogle Scholar9. LAMBERTROOKEEATONHODGSON EHEDLMCH: Myasthenic syndrome occasionally associated with bronchial neoplasm: neurophysiologic studies, in Myasthenia Gravis, ed. by Viets, H. R., Charles C Thomas, Springfield, Illinois, 1961, pp. 362-410. Google Scholar10. WINKELMANN RK: Dermatomyositis: method of R. K. Winkelmann, in Current Therapy, ed. by Conn, H. F., W. B. Saunders Company, Philadelphia, 1960, pp. 462-463. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, MinnesotaFrom the Mayo Clinic and Mayo Foundation, Rochester, Minnesota.Requests for reprints should be addressed to Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMyopathies inflammatoiresMiopatie infiammatorieSuccessful Treatment with Regimen of Intravenous Gammaglobulin and Cyclophosphamide for Dermatomyositis Accompanied by Interstitial Pneumonia, Opportunistic Infection and Steroid PsychosisCorticosteroid use in the treatment of neuromuscular disorders: Empirical and evidence-based dataThe safety of a resistive home exercise program in patients with recent onset active polymyositis or dermatomyositisTreatment and investigation of idiopathic inflammatory myopathiesIndications for intravenous gammaglobulin therapy in inflammatory myopathies.THERAPEUTIC OPTIONS IN DERMATOMYOSITIS/POLYMYOSITISThe use of corticosteroids in dermatological practiceEfficacy of intravenous gammaglobulin therapy in chronic refractory polymyositis and dermatomyositis: An open study with 20 adult patientsPolymyositis: A Case History Approach to the Differential Diagnosis and TreatmentAssociation of Inflammatory Myopathies with Other Connective Tissue Disorders and MalignanciesTreatment of Polymyositis and Dermatomyositis with Corticosteroids: A First Therapeutic ApproachPulmonary disease in polymyositis/dermatomyositisDermatomyositis in ChildhoodPrednisone and azathioprine for polymyositis. Long-term followupEvolution et pronostic à long terme de 50 cas de dermatomyosites et polymyositesAzathioprine with Prednisone for Polymyositis A Controlled, Clinical TrialTHOMAS W. BUNCH, M.D., JOHN W. WORTHINGTON, M.D., JOSEPH J. COMBS, M.D., DUANE M. ILSTRUP, M.S., ANDREW G. ENGEL, M.D.Dermatomyositis a Vocal and Swallowing Disease EntityLeuco-erythroblastosis following withdrawal from glucocorticoid therapy.The Spectrum of Polymyositis and DermatomyositisPolymyositis and Dermatomyositis: Combined Methotrexate and Corticosteroid TherapyALLAN L. METZGER, M.D., ANTHONY BOHAN, M.D., LEONARD S. GOLDBERG, M.D., F.A.C.P., RODNEY BLUESTONE, M.B., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P.THE SYNDROME OF MYASTHENIA AND POLYMYOSITIS WITH COMMENTS ON THERAPYEpidemiology of Systemic Sclerosis (Scleroderma)THOMAS A. MEDSGER JR., M.D., ALFONSE T. MASI, M.D., Dr. P.H., F.A.C.P.Factors Affecting Survivorship in Polymyositis. A Life-Table Study of 124 PatientsThe epidemiology of polymyositisGLUCOCORTICOIDS IN THE CONNECTIVE TISSUE DISEASESCorticotrofina e cortiomdes em neurologia: avaliação critica dos resultados em 518 pacientes hospitalizadosPolymyositis: A Clinical StudyR. G. LOGAN, M.D., J. M. BANDERA, M.D., W. M. MIKKELSEN, M.D., F.A.C.P., I. F. DUFF, M.D., F.A.C.P.Zur Begriffsbestimmung der sogenannten pseudomuskeldystrophischen Form der PolymyositisDritte wissenschaftliche SitzungThree Types of Pulmonary Involvement in Polymyositis 1 June 1963Volume 58, Issue 6Page: 969-976KeywordsAtrophyBloodDermatomyositisElectromyographyEnzymesMuscle biopsiesMusclesPolymyositisSteroid therapy Issue Published: 1 June 1963 PDF DownloadLoading ...