tbuckley/cabot-search huggingface dataset:
Drug‐induced aphthous ulcers
Authors: R.I. McLeod
Journal: British Journal of Dermatology (2000)

British Journal of DermatologyVolume 143, Issue 6 p. 1138-1139 Drug-induced aphthous ulcers R.I. McLeod, R.I. McLeod Edinburgh Dental Institute, Lauriston Building, Lauriston Place, Edinburgh EH3 9YW, U.K.Search for more papers by this author R.I. McLeod, R.I. McLeod Edinburgh Dental Institute, Lauriston Building, Lauriston Place, Edinburgh EH3 9YW, U.K.Search for more papers by this author First published: 24 December 2001 https://doi.org/10.1046/j.1365-2133.2000.04002.xCitations: 5 R.I.McLeod. Tel.: +131 536 4920; fax: +0131,5364901 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume143, Issue6December 2000Pages 1138-1139 RelatedInformation
Troponin T and B-Type Natriuretic Peptide After On-Pump Cardiac Surgery
Authors: Giovanna A.L. Lurati Buse, Daniel Bolliger, Esther Seeberger, Jorge Kasper, Martin Grapow, Michael T. Koller, Manfred D. Seeberger, Miodrag Filipovic
Journal: Circulation (2014)

Background— The independent predictive value of troponin T (TNT) after on-pump cardiac surgery was established in several studies. However, adjustment was limited to preoperative risk factors without considering perioperative complications. Data on the prognostic value of postoperative B-type natriuretic peptide (BNP) are scarce. Our aim was to assess the independent value of TNT and BNP to predict 12-month outcome after cardiac surgery with adjustment for preoperative risk estimates and postoperative complications and to report risk stratification gains when considering the European System for Cardiac Operative Risk Evaluation (EuroSCORE) combined with postoperative biomarkers. Methods and Results— This prospective cohort study included consecutive patients undergoing on-pump cardiac surgery between 2007 and 2010. We evaluated postoperative TNT and BNP, the EuroSCORE, and postoperative complications as predictors of adverse events using Cox regression. The primary end point was death or major adverse cardiac events within 1 year after surgery. We calculated the net reclassification index of TNT and BNP in addition to the EuroSCORE. We enrolled 1559 patients, of whom 176 (11.3%) experienced an event. The adjusted hazard ratio of TNT &gt;0.8 μg/L was 2.13 (95% confidence interval, 1.47–3.15) and of BNP &gt;790 ng/L was 2.44 (95% confidence interval, 1.65–3.62). The net reclassification index of the addition of TNT and BNP to the EuroSCORE was 0.276 (95% confidence interval, 0.195–0.348). Conclusions— Postoperative TNT and BNP are strong predictors of 1-year events after on-pump cardiac surgery independent of preoperative risk factors and postoperative complications. Updating the preoperative EuroSCORE risk with postoperative TNT and BNP after surgery allows for improved prediction of 1-year death or major adverse cardiac events.
Reversal of ouabain-induced arrhythmias in the dog by intravenous arginine hydrochloride
Authors: K. G. M. M. Alberti, A. A. Shahriari, H. D. Levine, D. P. Lauler
Journal: Cardiovascular Research (1971)

Journal Article Reversal of ouabain-induced arrhythmias in the dog by intravenous arginine hydrochloride Get access K. G. M. M. Alberti, K. G. M. M. Alberti 2 From the Department of Medicine, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Massachusetts, U.S.A. 2Present address and requests for reprints: Nuffield Department of Medicine, Radcliffe Infirmary, Oxford. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ali A. Shahriari, Ali A. Shahriari From the Department of Medicine, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold D. Levine, Harold D. Levine From the Department of Medicine, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar David P. Lauler David P. Lauler From the Department of Medicine, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 5, Issue 2, April 1971, Pages 226–235, https://doi.org/10.1093/cvr/5.2.226 Published: 01 April 1971
UK policy to reduce skills drain from Africa is ineffective
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

The UK government's policy of banning healthcare staff who are actively recruited from the world's poorest countries from working in the NHS is unlikely to help achieve the goal of boosting the number of doctors and nurses in the developing world, says a development specialist.

Dr Lola Banjoko, chairwoman of the Africa-wide recruitment and employment agency Africa Recruit, believes that the code of practice, which aims to restrict recruitment of healthcare professionals from 150 developing countries is well meaning. But she says that the policy cannot work in isolation. “Trying to stop people from moving from one country to another for work is not practically workable and is an infringement of people's human rights,” said Dr Banjoko. Africa Recruit aims to boost professional capacity throughout the continent.

Dr …
Dr. MacCormack in Lincoln County, Kentucky.
Authors: Steele Bailey
Journal: JAMA (1906)

Stanford, Ky., June 1, 1906. <h3>To the Editor:</h3> —In the language of the "sport," Dr. J. N. MacCormack, of Bowling Green, the representative of the American Medical Association, has been "going some" during the month of May. Except it be one in the flush of full health, as is usual with Dr. MacCormack, he could ill withstand the mental and physical strain through which he has recently gone. Meeting with recognition and encouragement everywhere enables him to keep young. His itinerary, arranged for him by the council of the Kentucky State Medical Association, began on May 1 and ended on the evening of May 26. He delivered in the 26 days (Sundays excepted), 38 addresses, which, like the stories of the sea god's daughters, are neither the same, nor yet different, but as sisters should be. I would not presume to speak for other sections, but am able to compute
Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL
Authors: Daniel Nagel, Stefani Spranger, Michelle Vincendeau, Michael Grau, Silke Raffegerst, Bernhard Kloo, Daniela Hlahla, Martin Neuenschwander, Jens Peter von Kries, Kamyar Hadian, Bernd Dörken, Peter Lenz, Georg Lenz, Dolores J. Schendel, Daniel Krappmann
Journal: Cancer Cell (2012)
Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli
Authors: Zhong-Gao Xu, Tae-Hyun Yoo, Dong-Ryeol Ryu, Hyeong Cheon Park, Sung Kyu Ha, Dae Suk Han, Sharon G. Adler, Rama Natarajan, Shin-Wook Kang
Journal: Kidney International (2005)
Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis
Authors: Sakari Reitamo, Malcolm Rustin, Thomas Ruzicka, Frédéric Cambazard, Kirsti Kalimo, Peter S. Friedmann, Erwin Schoepf, Mourad Lahfa, Thomas L. Diepgen, Harryono Judodihardjo, Andreas Wollenberg, John Berth-Jones, Thomas Bieber
Journal: Journal of Allergy and Clinical Immunology (2002)
Perforated and Embedded Intrauterine Devices
Authors: Charles H. Wright
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Zakin et al (1982; 247:2144), in their article entitled "Perforated and Embedded Intrauterine Devices," failed to mention a method of managing its complication that has served me well. The following case illustrates its use. <h3>Report of a Case.—</h3> A 39-year-old woman, para 2, reappeared 15 years after the insertion of an intrauterine device (IUD), demanding its removal. Since the string was not visible, an ultrasound study confirmed that it was still present. Efforts to remove it in the office failed. The patient was hospitalized a few days later with a temperature of 38 °C and pelvic pain but no pelvic mass. She was taken to the operating room. While probing for the IUD, I opened a posterior myometrial abscess, from which 10 to 15 mL of pus escaped. Further surgery was abandoned for fear of perforating the uterine wall. A drain was left in the cavity, and
Intravenous Streptokinase in Acute Myocardial Infarction (I.S.A.M.) trial: Serial evaluation of left ventricular function up to 3 years after infarction estimated by radionuclide ventriculography
Authors: Eberhard Voth, Ulrich Tebbe, Harald Schicha, Karl-Ludwig Neuhaus, Rolf Schröder
Journal: Journal of the American College of Cardiology (1991)
Ammonia transport by early and late proximal convoluted tubule of the rat.
Authors: D W Good, T D DuBose
Journal: Journal of Clinical Investigation (1987)

Free-flow micropuncture experiments were performed to examine ammonia transport separately in early and late proximal convoluted tubule (PCT) of the rat. In control rats, ammonia was secreted along the early PCT but was reabsorbed along the late PCT. In rats with chronic metabolic acidosis, ammonia secretion along the early PCT was increased compared with controls, and ammonia absorption by the late PCT was converted to small net ammonia secretion. In the acidotic rats, ammonia secretion rate in the early PCT was six times higher than that in the late PCT. Thus, most or all of ammonia secretion by the PCT occurred along its early portion. In control and acidotic rats, luminal NH3 concentration in the early PCT was significantly higher than that in the late PCT, indicating that ammonia is not in diffusion equilibrium throughout the renal cortex. It is proposed that differences in ammonia transport rate in early vs. late PCT may be due to differences in ammonia production rate and/or to differences in the rate of an ammonia backflux that detracts from net ammonia secretion.
Evidence based medicine is broken
Authors: D. Spence
Journal: BMJ (2014)

Re: Evidence based medicine is brokenDes Spence cites "poor regulation" as one of the phenomena that compound the profit-driven pollution of Evidence-Based Medicine (EBM).[1]He is not alone.This conception seems to be gaining in popularity.[2,3] Indeed, the current regulation is handmaiden to the polluters, as this partial list of examples indicates:• The regulation does not demand that the research agenda be driven strictly by patient needs, not corporate interests.• It is silent about the adequacy of selection criteria, outcome measures, and statistical significance, three variables that are often used by the polluters to manipulate evidence.
Policy makers face a growing range of illicit drugs and aggressive marketing
Authors: R. Watson
Journal: BMJ (2009)

<h3>Background</h3> Ethnic disparities in perinatal mortality are well known. This study aimed to explore the contribution of demographic, socioeconomic, health behavioural and pre-existent medical risk factors among different ethnic groups on fetal and early neonatal mortality. <h3>Methods</h3> We assessed perinatal mortality from 24.0 weeks9 gestation onwards in 554 234 singleton pregnancies of nulliparous women in the linked Netherlands Perinatal Registry over the period 2000–2006. Logistic regression modelling was used. <h3>Results</h3> Considerable ethnic differences in perinatal mortality exist especially in fetal mortality. Maternal age, socioeconomic status and pre-existent diseases could not explain these ethnic differences. Late booking visit could explain some differences. Compared with the Dutch, African women had an increased fetal mortality risk of OR 1.7 (95% CI 1.4 to 2.1); South Asian women, 1.8 (1.4 to 2.3); other non-Western women, 1.3 (1.1 to 1.6) and Turkish/Moroccan women, 1.3 (1.1 to 1.4). The risk on early neonatal mortality was only increased in other non-Western women, OR 1.3 (1.0 to 1.8). Ethnic differences were even present in the women without risk factors including preterm births. Mortality risk for East Asian and other Western women was lower or comparable with the Dutch. <h3>Conclusion</h3> Important ethnic differences in fetal mortality exist, especially among women of African and South Asian origin. Ethnic minorities should be more acquainted with the significance of early start of prenatal care. Tailored prenatal care for women with African and South Asian origin seems necessary. More research on underlying cause of deaths is needed by ethnic group.
Bronchial Breathing and Rales: A Clinical Demonstration on some of the Difficulties of Auscultation given at St. Bartholomew's Hospital
Authors: S. West
Journal: BMJ (1897)

AUSCULTATION is not really a difficult subject.It requires some little preliminary instruction, and after that its mastery is only a question of attention and practice; yet there is no doubt that it often appears confusing to students.The difficulties, however, are chiefly of our own making, and lie not in things but in words; for the facts of auscultation, their significance, and their relation to pathological lesions, are well known and understood, while the confusion lies in the technical terms used to express the phenomena observed.Among these technical terms the chief offenders are the two with which I propose to deal to-day, namely, bronchial breathing and rales.Technical terms are convenient, but to be really useful they must be strictly defined and accurately used; otherwise they introduce confusion instead of simplicity, and that is the case in auscultation.If we could only get rid of technical terms, and merely describe in simple language what we actually hear, there would be no confusion and little difficulty.Students feel this confusion of terms throughout their career, but most acutely at two periods of it: early, when they are first beginning to study auscultation; and later, when
Marion Hildick-Smith
Authors: D. Hildick-Smith, W. Hildick-Smith, P. Hildick-Smith, B. Hildick-Smith
Journal: BMJ (2011)

Marion Hildick-Smith was born and educated in Swansea, and won an exhibition to read maths at Oxford. She chose instead to attend Newnham College, Cambridge. She changed to medicine and completed her training as one of the first women at St Thomas’s Hospital. She and her husband, John, …
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
Authors: William Lee, Sewit Teckie, Thomas Wiesner, Leili Ran, Carlos N Prieto Granada, Mingyan Lin, Sinan Zhu, Zhen Cao, Yupu Liang, Andrea Sboner, William D Tap, Jonathan A Fletcher, Kety H Huberman, Li-Xuan Qin, Agnes Viale, Samuel Singer, Deyou Zheng, Michael F Berger, Yu Chen, Cristina R Antonescu, Ping Chi
Journal: Nature Genetics (2014)
Abortion reform's lessons for assisted dying
Authors: A. M. Houghton
Journal: BMJ (2012)

<h3>Abstract</h3> Although metacommunity ecology has been a major field of research in the last decades, with both conceptual and empirical outputs, the analysis of the temporal dynamics of metacommunities has only emerged recently and consists mostly of repeated static analyses. Here, we propose a novel analytical framework to assess metacommunity processes using path analyses of spatial and temporal diversity turnovers. We detail the principles and practical aspects of this framework and apply it to simulated datasets to illustrate its ability to decipher the respective contributions of entangled drivers of metacommunity dynamics. We then apply it to four empirical datasets. Empirical results support the view that metacommunity dynamics may be generally shaped by multiple ecological processes acting in concert, with environmental filtering being variable across both space and time. These results reinforce our call to go beyond static analyses of metacommunities that are blind to the temporal part of environmental variability.
Musculoskeletal applications of magnetic resonance imaging. Council on Scientific Affairs
Authors: S.E. Harms, C.F. Fisher, J.M. Fulmer
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeting and Killing of Metastatic Cells in the Transgenic Adenocarcinoma of Mouse Prostate Model With Vesicular Stomatitis Virus
Authors: Maryam Moussavi, Howard Tearle, Ladan Fazli, John C Bell, William Jia, Paul S Rennie
Journal: Molecular Therapy (2013)

Vesicular stomatitis virus (VSV) is an oncolytic virus which selectively infects and kills cancer cells. The goal of the present study was to determine whether VSV is capable of targeting metastatic lesions that arise in situ in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. The interferon (IFN)-responsive luciferase containing VSV(AV3) strain was injected intraprostatically into both control and TRAMP mice. Distribution, infectivity, apoptosis, and status of the IFN response were evaluated at the site of viral injection (prostate), as well as in metastatic lesions (lymph nodes), through plaque, polymerase chain reaction (PCR), and immunohistochemical analysis. Bioluminescence analyses demonstrated that VSV(AV3) persisted at high levels in the prostate region of TRAMP mice for up to 96 hours, but at relatively low levels and for only 48 hours in control mice. Live virus was discovered in the lymph nodes of TRAMP mice, but not in control mice. TUNEL staining revealed increased cell death in VSV(AV3) infected metastatic cells present in the lymph nodes of TRAMP mice. There was an evidence of IFN activation in lymph nodes containing metastatic cells. Our results indicate that intraprostatic injections of VSV(AV3) can be used as a means to infect and kill metastatic lesions associated with advanced prostate cancer.
Outbreak of coagulase negative staphylococcus highly resistant to ciprofloxacin in a leukaemia unit.
Authors: B. A. Oppenheim, J. W. Hartley, W. Lee, J. P. Burnie
Journal: BMJ (1989)

OBJECTIVE--To define an outbreak of bacteraemia due to coagulase negative staphylococci highly resistant to ciprofloxacin in a leukaemia unit, investigate the source and mode of spread of the outbreak strain, and assess control measures. DESIGN--The outbreak strain was characterised by five different typing methods. Surveillance of patients, staff, and environment was carried out during the outbreak and five months after control measures were introduced. SETTING--A unit with 10 beds for adults with leukaemia and patients receiving bone marrow transplants. The outbreak occurred during a trial of ciprofloxacin for empirical treatment of neutropenic fevers. INTERVENTIONS--Ciprofloxacin was withdrawn from use in the unit and daily bathing with chlorhexidine gluconate solution started. Main outcome measure--The absence of bacteraemia due to the outbreak strain for five months after control measures. RESULTS--During the study 49 patients developed 21 episodes of bacteraemia due to the outbreak strain, which was ciprofloxacin resistant (minimum inhibitory concentration greater than or equal to 128 mg/l), susceptible to phage 155 A9C, and SII biotype and had characteristic immunoblot and DNA fingerprint features. There was a high amount of colonisation of patients but not staff with this strain, which was also wide spread in the environment. The control measures led to rapid resolution of the outbreak and disappearance of the strain from the unit. CONCLUSIONS--In areas where coagulase negative staphylococcal infections are common doctors must be aware of the possibility of cross infection with single strain, and the availability of more discriminatory methods of typing will facilitate the identification and control of such episodes.
Occurrence of Multiple Fibrofatty Replacements Exclusively in the Left Ventricle of a Patient With Monomorphic Sustained Ventricular Tachycardia
Authors: Koki Nakamura, Nobusada Funabashi, Hideyuki Miyauchi, Mari Aminaka, Masae Uehara, Marehiko Ueda, Takashi Nakayama, Nakabumi Kuroda, Yoshio Kobayashi, Hiroyuki Takano, Issei Komuro
Journal: Circulation (2007)
INSTRUMENT FOR USE IN PHOTOTHERAPY.
Authors: J. W. KIME
Journal: JAMA (1900)

I have devised and am now using, in the treatment of cases by means of concentrated light, a reflector which is so constructed that the direct rays of the sun falling on it are focussed at a distance of eight feet, on an area six inches in diameter, the reflector being thirty inches in diameter. Thus a light is produced equal in intensity to twenty times that of direct sunlight, and covering an area of twenty-eight square inches. As the actinic rays of the sun are desired rather than the heat rays, blue glass is placed in front of the reflector, which permits of the passage of the light in nearly its full strength, but excludes a large percentage of the heat rays. The reflector is mounted on a metal stand which permits of motion in all directions. The light from this reflector is as powerful as it is possible
Treatment of Malignant Melanoma of the Orbit with Intra-Arterial Methotrexate
Authors: Stanley N. Levick
Journal: JAMA (1962)

REGIONAL PERFUSION and infusion is developing into an increasingly important technique in the treatment of malignant tumors. Creech et al. and other investigators have reported on the treatment of malignant melanoma and other malignant tumors of an extremity by regional perfusion with the alkylating agents. Sullivan et al. reported in 1959 on the treatment of epithelial tumors of the head and neck by the continuous infusion of very large doses of an antimetabolite—methotrexate (4-amino-N-methyl-pteroylglutamic acid)—through the external carotid artery. Citrovorum factor (the antidote to methotrexate) was administered intermittently during this procedure by the intramuscular route to neutralize, to some degree, systemic toxicity. Subsequently these authors also reported the treatment of cancer of the cervix and of the brain by the same method. The results of these procedures were encouraging and resulted in some remissions lasting many months. Prior to our case, the above technique had never been used in the