Vasospastic Reaction to Methysergide Maleate Simulating Leriche Syndrome
Authors: HARRY W. DANIELL
Journal: Annals of Internal Medicine (1964)

Case Studies1 May 1964Vasospastic Reaction to Methysergide Maleate Simulating Leriche SyndromeIneffective Treatment with Adrenergic BlockadeHARRY W. DANIELLHARRY W. DANIELLAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-5-881 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLong-term methysergide maleate (Sansert®) administration has recently been advocated as an effective preventative for vascular headaches. Reports of its effectiveness are well documented (1-3), and its use appears to be expanding rapidly. Few serious side effects have been reported, although occasional patients have reported the onset of vasospastic symptoms, including angina pectoris (1, 4) or intermittent claudication of the calf muscles (1, 3). These symptoms have disappeared with decrease in dosage or discontinuation of the medication. The mechanism by which methysergide induces vessel spasm is not understood, and pharmacologic attempts at modifying this unusual effect have not been reported.This...References1. GRAHAM JR: Use of new compound UML-491 (1-Methyl-D-Lysergic Acid Butanolamide) in prevention of various types of headache: pilot study. New Eng. J. Med. 263: 1273, 1960. CrossrefMedlineGoogle Scholar2. FRIEDMANLOSIN APS: Evaluation of UML-491 in treatment of vascular headache. Arch. Neuro. 4: 241, 1961. CrossrefMedlineGoogle Scholar3. ROOKERUSHTONPETERS EDJGGA: Vasodilating headache: suggested classification and results of prophylactic treatment with UML-491 (methysergide). Proc. Mayo Clin. 37: 433, 1962. MedlineGoogle Scholar4. FRIEDMANELKIND APAH: Appraisal of methysergide in treatment of vascular headaches of migraine type. JAMA 184: 139, 1963. CrossrefGoogle Scholar5. URELESROB ALC: Acute ischemia of a limb complicating methysergide maleate therapy. JAMA 183: 1041, 1963. CrossrefMedlineGoogle Scholar6. DALESSIOCAMPGOODELLWOLFF DJWAHHG: Studies on headache: mode of action of UML-491 and its relevance to nature of vascular headache of migraine type. Arch. Neuro. 4: 235, 1961. CrossrefMedlineGoogle Scholar7. DALESSIO DJ: On migraine headache—serotonin and serotonin antagonism. JAMA 181: 318, 1962. MedlineGoogle Scholar8. HALPERN A: Raynaud's disease, Raynaud's phenomenon and serotonin. Angiology 11: 151, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC El Paso, TexasFrom William Beaumont General Hospital, El Paso, Texas.Requests for reprints should be addressed to Major Harry W. Daniell, Veterans Administration Hospital, Roseburg, Oregon. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystemic Pharmacology of Adrenergic Agonists and Antagonists: Effects on the Digestive SystemFasciitis and FibrosisToxicologic ConsiderationsCarotid Artery Occlusion Following Ingestion of LSDAortic disease in idiopathic retroperitoneal and mediastinal fibrosisSpasm of large peripheral arteries may complicate ergotamine tartrate therapy. A case is reported showing the characteristic features of predominant involvement of lower limbs, rapid improvement on cessation of ergotamine and arteriographic demonstration of a smooth narrowing, reversed on drug withdrawal. The mechanism of action, predisposing factors, individual susceptibility and arteriographic findings are discussed.The influence of 2-(2,6-dichlorphenylamino)-2-imidazoline hydrichloride (clonidine) and some related compounds on gastric secretion in the anaesthetized ratIV. Miscellaneous arterial lesionsMethysergide and retroperitoneal fibrosisTherapy of the Malignant Carcinoid SyndromeCHARLES E. MENGEL, M.D. 1 May 1964Volume 60, Issue 5Page: 881-885KeywordsAnginaHipMuscles Issue Published: 1 May 1964 PDF downloadLoading ...