tbuckley/cabot-search huggingface dataset:
Positional Right-to-Left Shunting
Authors: Matthew J. Sorrentino
Journal: Annals of Internal Medicine (1993)

Letters15 March 1993Positional Right-to-Left ShuntingMatthew J. Sorrentino, MDMatthew J. Sorrentino, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-6-199303150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Wright and colleagues [1] describe a patient with platypnea and orthodeoxia due to right-to-left shunting across an atrial septal defect, presumably because of high right atrial pressures caused by right ventricular dysfunction from eosinophilic endomyocardial disease. The protocol suggests that the patient had significant cyanosis and symptoms in the supine position. Classically, the terms platypnea and orthodeoxia are used to describe the relief of symptoms in the supine position and the development of symptoms in the sitting or standing positions. Thus, further desaturation with sitting could have occurred only with an increase in shunt. No plausible explanation ...References1. Wright RS, Simari RD, Orszulak TA, Edwards WD, Gleich GJ, Reeder GS. Eosinophilic endomyocardial disease presenting as cyanosis, platypnea, and orthodeoxia. Ann Intern Med. 1992; 117:482-3. Google Scholar2. Sorrentini MJ, Resnekov L. Patent foramen ovale associated with platypnea and orthodeoxia. Chest. 1991; 100:1157-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Matthew J. Sorrentino, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1993Volume 118, Issue 6Page: 473-474KeywordsAgingAtrial septal defectBloodInferior vena cavaPatient advocacy ePublished: 15 August 2000 Issue Published: 15 March 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Needleknife Precut Sphincterotomy: The Devil is in the Indications
Authors: P. B. Cotton
Journal: Endoscopy (1997)

See also: Needle-Knife Sphincterotomy as a Precut Procedure: A Retrospective Evaluation of Efficacy and ComplicationsEndoscopy 1996; 28(04): 334-339DOI: 10.1055/s-2007-1005476
Primary Salmonella typhi meningitis in an adult.
Authors: D Chanmugam, V Machado, J C Mihindukulasuriya
Journal: BMJ (1978)

bacterial overgrowth in the intestinal lumen.After relief of the small- bowel obstruction by removal of his tumour, one would assume that bacterial overgrowth would not be a feature, and certainly three months after his operation there were no clinical or biochemical features of malabsorption.This may be relevant to the disappearance of our patient's clubbing.
PERCUTANEOUS ABSORPTION OF TRITIUM-LABELLED BETAMETHASONE-17-VALERATE.
Authors: JOAN BUTLER
Journal: British Journal of Dermatology (1966)

Journal Article PERCUTANEOUS ABSORPTION OF TRITIUM‐LABELLED BETAMETHASONE‐17‐VALERATE. Get access JOAN BUTLER, M.A., Cantab. JOAN BUTLER, M.A., Cantab. Research Assistant, Department of Chemical Pathology, King's College Hospital Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 12, 1 December 1966, Pages 665–668, https://doi.org/10.1111/j.1365-2133.1966.tb12171.x Published: 01 December 1966
Extracellular matrix components and regulators in the airway smooth muscle in asthma
Authors: B. B. Araujo, M. Dolhnikoff, L. F. F. Silva, J. Elliot, J. H. N. Lindeman, D. S. Ferreira, A. Mulder, H. A. P. Gomes, S. M. Fernezlian, A. James, T. Mauad
Journal: European Respiratory Journal (2008)

There is an intimate relationship between the extracellular matrix (ECM) and smooth muscle cells within the airways. Few studies have comprehensively assessed the composition of different ECM components and its regulators within the airway smooth muscle (ASM) in asthma. With the aid of image analysis, the fractional areas of total collagen and elastic fibres were quantified within the ASM of 35 subjects with fatal asthma (FA) and compared with 10 nonfatal asthma (NFA) patients and 22 nonasthmatic control cases. Expression of collagen I and III, fibronectin, versican, matrix metalloproteinase (MMP)-1, -2, -9 and -12 and tissue inhibitor of metalloproteinase-1 and -2 was quantified within the ASM in 22 FA and 10 control cases. In the large airways of FA cases, the fractional area of elastic fibres within the ASM was increased compared with NFA and controls. Similarly, fibronectin, MMP-9 and MMP-12 were increased within the ASM in large airways of FA cases compared with controls. Elastic fibres were increased in small airways in FA only in comparison with NFA cases. There is altered extracellular matrix composition and a degradative environment within the airway smooth muscle in fatal asthma patients, which may have important consequences for the mechanical and synthetic functions of airway smooth muscle.
PLATELET INHIBITORY EFFECT OF CLOPIDOGREL IN PATIENTS TREATED WITH OMEPRAZOLE, PANTOPRAZOLE, OR FAMOTIDINE A PROSPECTIVE RANDOMIZED CROSSOVER STUDY
Authors: Yaron Arbel, Edo Birati, Yigal Abramowitz, Shlomo Berliner, amir halkin, Varda Deutsch, Itzhak Herz, Gad Keren, Ariel Finkelstein, Shmuel Banai
Journal: Journal of the American College of Cardiology (2012)
Umbilical Vascular Catheterization
Authors: Jo Dee Anderson, Douglas Leonard, Dana A.V. Braner, Susanna Lai, Ken Tegtmeyer
Journal: New England Journal of Medicine (2008)

The placement of umbilical catheters is an essential technique for the treatment of many newborns in unstable condition. This video will demonstrate the placement of catheters in the umbilical vein and the umbilical artery. Careful preparation, sterile technique, and attention to detail are instrumental in successful catheter placement. We will demonstrate the regional anatomy of the umbilicus, indications and contraindications for the insertion of an umbilical catheter, the recommended technique for catheter placement in both the umbilical artery and vein, selected complications associated with the procedure and suggestions for how to avoid them, and appropriate aftercare of the catheter. . . . .
Prevention of atrial fibrillation by atrial overdrive pacing: Final results of a randomized crossover study
Authors: Karl-Heinz Konz, Johannes Brachmann, Patrick Attuel, Dia El Allaf, Candido Gomes, Istvan Szendey, Volker Schibgilla, Dejan Danilovic
Journal: Journal of the American College of Cardiology (2003)
Preoperative integrity of skin surface predicts infection risk
Authors: S. C Weatherhead, C. M Lawrence
Journal: BMJ (2009)

Heal and colleagues report a reduced risk of wound infection with topical antibiotics after minor skin surgery.1 However, the control group had a high risk of infection and the influence of pre-existing carriage of skin pathogens, as shown by the appearance of the lesion’s surface, was not considered.

Our prospective study shows that patients whose lesion preoperatively had …
Metronidazole and Cancer
Authors: David A. Danielson
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Although metronidazole is mutagenic in rats<sup>1</sup>and mice,<sup>2</sup>and is reported to alter DNA synthesis,<sup>3</sup>two previous human studies<sup>4,5</sup>have found no positive association between metronidazole use and cancer rates. In view of the limited amount of available human data, we report here on a follow-up study of some 12,000 users of metronidazole in relation to the subsequent development of certain cancers. The investigation was carried out in cooperation with Group Health Cooperative (GHC) of Puget Sound, a comprehensive health organization in Seattle, which dispenses drugs prescribed to its members through conveniently located GHC pharmacies. The plan operates hospitals providing inpatient services to all members. From 1977 through 1979, the average GHC enrollment was about 265,000 members. All hospitalizations and drug prescriptions dispensed by the GHC since July 1976 are on computer files.<sup>6</sup>Thus, exposure to specific drugs and incident cases of diseases
Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3.
Authors: D P Gold, H Offner, D Sun, S Wiley, A A Vandenbark, D B Wilson
Journal: The Journal of Experimental Medicine (1991)

This study explores the usage of T cell antigen receptor (TCR) beta chain elements in Lewis rats with experimentally induced allergic encephalomyelitis (EAE). TCRs from 15 different T cell clones and hybridomas derived from animals immunized with myelin basic protein (MBP), and all having specificity for the 21-mer encephalitogenic fragment MBP 68-88, utilized V beta 8.2. In addition, there was a marked conservation of the first two amino acid residues of the junctional complementarity determining region 3 (CDR3) associated with the V beta 8.2 receptors. 12 of 15 contained an aspartic acid followed by serine regardless of the associated J beta element. At the nucleotide level, this conservation of AspSer residues was accomplished with few or no nongermline-encoded nucleotide (N) additions. A similar pattern of AspSer usage and N region nucleotide additions was observed in a number of V beta 8.2 isolates derived from MBP-immunized lymph nodes. In contrast, V beta 8.2 polymerase chain reaction amplified isolates from Lewis T cells activated with concanavalin A or from lymph nodes of complete Freund's adjuvant-immunized animals showed no AspSer utilization (0/31) in the CDR3, and four to nine N region nucleotide additions. We conclude from this finding that AspSer residues in the CDR3, limited N region nucleotide additions, along with V beta 8.2 sequences, contribute to TCR specificity for MBP 68-88. This raises the possibility that encephalitogenic, disease-causing T cells either represent a population that derives from late fetal life or alternatively, that they are rare cells with this particular TCR phenotype contributed to the T cell pool throughout adulthood and are selected by antigen. In either case, the CDR3 AspSer sequences as well as V beta 8.2 sequences are candidates for the receptor target structures recognized by regulator T cells in recovery from and resistance to active EAE. In this respect, a preliminary analysis of TCR utilization in three T cell clones specific for MBP 68-88 isolated from animals recovered from active EAE indicates that while all three use V beta 8.2, only one contains AspSer in the CDR3.
Factors in the host-virus relationship which may affect the course of an infection.
Authors: H. E. Webb
Journal: BMJ (1968)

Many differing clinical pictures may be caused by the same virus when introduced into humans or animals. It is generally accepted that in an epidemic of poliomyelitis one may see patients who have (1) no illness but develop immunity, (2) a mild febrile illness, (3) an aseptic meningitis, (4) lower motor neurone paralysis, or (5) encephalitis. One may also see patients with advanced complete paralysis who subsequently recover completely. These differing presentations are accepted as clinical facts, but little has been done to explain why one of these particular situations should apply to one individual and not to another. Recently, the role of viruses in disease processes has become even more intriguing by the finding of what appear to be viruses associated with more chronic long-term illnesses, such as subacute sclerosing panencephalitis (Bouteille et al., 1965; Connolly et al., 1967) and progressive multifocal leuco encephalopathy (Howatson et al., 1965). There are many factors that will affect the course of a viral illness.
Serum Phenytoin Concentrations in Uremia
Authors: LOIS ALDWIN
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 December 1981Serum Phenytoin Concentrations in UremiaLOIS ALDWIN, PH.D., DAVID S. KABAKOFF, PH.DLOIS ALDWIN, PH.D.Search for more papers by this author, DAVID S. KABAKOFF, PH.DSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-6-785_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Burgess and associates (1) have presented evidence that homogeneous enzyme immunoassay (EMIT; Syva Corporation, Palo Alto, California) yields falsely high results for phenytoin concentrations as compared with gas-liquid chromatography on samples from patients with end-stage renal disease. Serum phenytoin ascertainments for control patients with normal renal function were not statistically different for the two methods.The authors tested the hypothesis that metabolite interference caused the apparent increase in phenytoin by measuring serum phenytoin concentration before and after hemodialysis in 16 patients. They found a median decrease in serum hydroxyphenyl phenylhydantoin (HPPH)-glucuronide, the major phenytoin metabolite, from 33.6...References1. BURGESSFRIELBLAIRRAISYS EPAV. Serum phenytoin concentrations in uremia. Ann Intern Med. 1981;94:59-60. LinkGoogle Scholar2. ALDWINKABAKOFF LD. Metabolite interference in homogeneous enzyme immunoassay of phenytoin. Clin Chem. 1981;27:770-1. Letter. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Syva Company Palo Alto, CA 94303 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhenytoin and Phenobarbital Concentrations in Renal InsufficiencyJOHN W. TURK, M.D., PH.D., JACK H. LADENSON, PH.D. 1 December 1981Volume 95, Issue 6Page: 785-785KeywordsAttentionEnzyme immunoassayEnzyme multiplied immunoassay techniqueGas liquid chromatographyMetabolitesRenal failure Issue Published: 1 December 1981 PDF downloadLoading ...
Adjuvant Therapy for Early Breast Cancer
Authors: Serban-Dan Costa, Joachim Bischoff
Journal: New England Journal of Medicine (2007)

To the Editor: Poole et al. (Nov. 2 issue)1 conclude that patients with breast cancer benefit from the addition of four cycles of epirubicin to cyclophosphamide, methotrexate, and fluorouracil (CMF...
Chinese rules on transplantation do not go far enough
Authors: Jane Parry
Journal: BMJ (2006)

New guidelines covering organ transplantations in China fail to address basic issues such as brain death and the source of organs, one of the country's leading transplantation surgeons has said.

Chen Zhonghua, director of the Institute of Organ Transplantation at Tongji Medical College, Wuhan, who helped to draw up the rules, said last week that China's lack of a legal definition of brain death was a major obstacle to promoting an organ supply that was in line with international ethical standards. The guidelines …
Echocardiographic study of the paradoxical arterial pulse in chronic obstructive lung disease.
Authors: H P Settle, P J Engel, N O Fowler, J M Allen, C L Vassallo, J N Hackworth, R J Adolph, D C Eppert
Journal: Circulation (1980)

In nine subjects with chronic obstructive pulmonary disease (COPD) and pulsus paradoxus, M-mode echocardiograms showed inspiratory augmentation of right ventricular dimensions and inspiratory decrease of left ventricular diastolic dimensions. In five subjects in whom the echocardiographic transistor was in the subxiphoid position, mean right ventricular dimensions increased during inspiration from 1.4 +/- 0.20 to 2.96 +/- 0.38 cm (p &lt; 0.01). With inspiration, mean left ventricular diastolic dimensions decreased from 4.8 +/- 0.61 to 3.7 +/- 0.63 cm (p &lt; 0.01) in these five subjects. Two-dimensional echocardiograms, performed in three subjects, confirmed inspiratory augmentation of right ventricular cross-sectional area. Similar changes were produced in two normal volunteers by artificial obstruction to breathing. Left ventricular ejection time measurements demonstrated an inspiratory decline in left ventricular stroke volume. Inspiratory filling of the right ventricle is not hampered, but rather is exaggerated in patients with COPD and pulsus paradoxus, and left ventricular stroke volume is reduced during inspiration. Exaggerated variations in intrathoracic pressure alone did not explain pulsus paradoxus. Increased right ventricular filling and stroke volume during inspiration probably play a part.
TCT-299 Impact of Baseline Peri-Stent Plaque Volume on Positive Vessel Remodeling after Implantation of Paclitaxel Eluting Stents: A Pooled Volumetric Intravascular Ultrasound Analysis
Authors: Kenji Sakamoto, Katsuhisa Waseda, Hideki Kitahara, Ryotaro Yamada, Ching-Chang Huang, Paul Yock, Peter Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2012)
Adding depth to the picture
Authors: J.A.M. Van Gisbergen, V. Chaturvedi
Journal: Behavioral and Brain Sciences (1999)

Recent studies showing that pontine burst cells carry a monocular code for rapid eye movements raise questions about the organisation of signals at more central levels. Evidence that the superior colliculus may also be involved in the coding of movements in depth is reviewed. Recent work showing that the global effect is a property of refixations in 3-D space is another indication that the oculomotor systems for direction and depth are centrally coupled.
Extensor digitorum brevis--a predictor of neuropathy in the leg?
Authors: C T Kirkpatrick
Journal: BMJ (1982)

cardiac failure.Atrial fibrillation was present, but there was no cardiac enlargement and no murmurs.Chest radiography confirmed that the cardiac contour and size and lung fields were normal.Echocardiography showed no abnormality of either the mitral or aortic valve.Cardiac enzyme activities, electrolyte concentrations, and full blood count were all normal, and glandular fever screening test was negative.Complement fixation tests were negative for Coxiella burneti, Myocoplasma pneumoniae, influenza A and B, adenovirus, parainfluenza, herpes simplex, respiratory syncytial virus, and cytomegalovirus.Titres for psittacosis, however, were as follows: 8 on 22 December 80, 512 on 14 January 81, 512 on 18 February 81, 64 on 16 April 81, and 32 on 17 June 81.Treatment with tetracycline was started and continued for two months.By late January 1981 his symptoms had disappeared and when the titre to chlamydia B had fallen in May 1981 he was admitted to hospital for cardio- version because of persistence of atrial fibrillation.After successful cardio- version electrocardiography showed no evidence of pulmonary mitrale, ventricular hypertrophy, or myocardial ischaemia.Ten days later, after a mild flu-like illness, the heart lapsed into atrial fibrillation again despite maintenance quinidine treatment.Repeat cardioversion was not required as sinus rhythm occurred spontaneously after several days.Closer questioning failed to elicit any exposure to or contact with birds by the patient or any member of the family.
895. Ex Vivo Gene Therapy of Metabolic Liver Disorders Using Uncultured and Lentivirally Transduced Hepatocytes
Authors: Tuan Huy Nguyen, Jacques Birraux, Barbara Wildhaber, Catherine Fux, Francois Trivin, Anne Myara, Claude Lecoultre, Didier Trono
Journal: Molecular Therapy (2005)

Background: At the present time, orthotopic liver transplantation is the only effective therapy for several congenital and acquired hepatic disorders. Because of a chronic organ shortage, and of the necessity of heavy and lifelong immunosuppression after transplantation, gene therapy represents a promising alternative. We have previously described an ex vivo gene therapy protocol that allows very high rates of transduction of human hepatocytes (up to 98%), in which freshly isolated hepatocytes are transduced in suspension and immediately transplanted. This protocol is easily performed, rapid, does not required primary culture of hepatocytes, and preserves full cell engraftment potential and in vivo cell functionality. In this study, we used the Gunn rat, which is the model for Crigler-Najjar syndrome type I, a defect in bilirubin UDP-glucuronyltransferase (BGT), to evaluate our approach.
Treatment of Low-Renin Essential Hypertension
Authors: Janice G. Douglas
Journal: JAMA (1974)

Seventeen patients with  essential hypertension were studied in a double-blind comparison of the antihypertensive effect of spironolactone with that of a hydrochlorothiazide-triamterene combination. All 17 patients responded to spironolactone. The decrease in average mean blood pressure was 20.7 mm Hg accompanied by an average diuresis of —3.1 kg. Fourteen of the 17 patients had favorable responses to hydrochlorothiazide-triamterene. The average decrease in mean blood pressure was 17.0 mm Hg, and the average diuresis was —1.5 kg. The difference in mean blood pressure response was not statistically significant.  The fact that both forms of therapy were effective, even though their mechanisms of action differ, suggests that extracellular fluid volume reduction may be the key factor in the amelioration of hypertension in patients with low-renin essential hypertension.
Living-Donor Lobar Lung Transplantation for Pulmonary Arterial Hypertension After Failure of Epoprostenol Therapy
Authors: Hiroshi Date, Kengo Fukushima Kusano, Hiromi Matsubara, Aiko Ogawa, Hideki Fujio, Katsumasa Miyaji, Megumi Okazaki, Masaomi Yamane, Shinichi Toyooka, Motoi Aoe, Yoshifumi Sano, Motohiko Hanazaki, Keiji Goto, Shingo Kasahara, Shunji Sano, Tohru Ohe
Journal: Journal of the American College of Cardiology (2007)
Reply to J. S. Baudet et al.
Authors: A. Meining
Journal: Endoscopy (2008)

On behalf of all my co-authors I would like to express my thanks for the appreciation and overall positive feedback given by Dr. Baudet, Dr. Sánchez del Río, and Dr. Alarcón-Fernandez. I absolutely agree that patient safety and perceived quality (i. e. patient satisfaction) is essential in the assessment of overall quality of upper (and also lower) gastrointestinal endoscopy. It must, however, be stressed that there is a considerable body of data showing improved patient acceptance if propofol sedation is used. This is also highlighted by the fact that updated guidelines on sedation in endoscopy support the increasing importance of propofol sedation [1] [2]. Nevertheless, the purpose of our study was to provide evidence on the subjective feeling that propofol sedation is also associated with improved examination conditions from an examiner’s point of view (apart from its patient-related benefits). Because data on the acceptability of this type of sedation from the examiner’s standpoint have been sparse, we aimed to fill this gap.
Interaction between synoviocytes and extracellular matrix in vitro.
Authors: S E Carsons, J Wolf
Journal: Annals of the Rheumatic Diseases (1995)

Synoviocyte adhesion, migration, and proliferation are essential in the growth of pannus and the subsequent invasion of cartilage in inflammatory arthritis.These cellular functions are regulated by the extracellular matrix.'In vitro studies of synoviocytes have previously demonstrated that they display abnormal phenotypic properties, including a transformation-like morphology manifested by cell overlapping and focus formation.23 Abnormal synoviocyte phenotype has been shown to be strongly influenced by extra- cellular matrix; synoviocytes exhibit extensive focus formation when plated on exogenous fibronectin rich matrices or when primed to switch endogenous matrix production from a collagen enriched to a fibronectin enriched type.3To determine if the influence of matrix on synoviocyte morphology is associated with effects on synoviocyte ad- hesion and growth, we studied the effect of purified matrix components and a cell free matrix preparation isolated from human synovium on the attachment, spreading, and proliferation of human synoviocytes in vitro.