tbuckley/cabot-search huggingface dataset:
Renin and acute renal failure.
Authors: W J Dempster
Journal: BMJ (1970)

sensitivity of the assay (30 picograms/ml.).These results contrast with the failure of the plasma corticosteroid levels to respond to insulin or lysine vasopressin in a patient several months after the withdrawal of long-term prednisolone therapy given two to three times per day, in keeping with the findings of Livanou et al.3The details of these cases will be published in due course.Meanwhile it is clear that the theoretical disadvantage of depot tetracosactrin referred to by Drs.Treadwell and Dennis is not a practical reality, at least when it is used in a dosage of 0.5 mg.intramuscularly twice weekly.-Weare, etc.,
Association Between <b> <i>SAH</i> </b> , an Acyl-CoA Synthetase Gene, and Hypertriglyceridemia, Obesity, and Hypertension
Authors: Naoharu Iwai, Tomohiro Katsuya, Toshifumi Mannami, Jitsuo Higaki, Toshio Ogihara, Koichi Kokame, Jun Ogata, Shunroku Baba
Journal: Circulation (2002)

The SA gene (SAH) has been isolated by differential screening from a genetically hypertensive rat strain as a candidate gene that may contribute to hypertension. Recently, the SA protein has been reported to be highly homologous to bovine xenobiotic-metabolizing medium-chain fatty acid:CoA ligase.To clarify the pathophysiological significance of SAH, we searched for polymorphisms of human SAH and performed association studies using a large cohort (4000 subjects) representing the general population in Japan. We found 2 polymorphisms in the promoter region and single-nucleotide polymorphisms in introns 5, 7, and 12 and exon 8. One of the variants, an A/G polymorphism in intron 12, just 7 bp upstream from exon 13, strongly affected plasma triglyceride, plasma cholesterol, body mass index (BMI), waist-to-hip ratio (W/H), and blood pressure status. The effect of this genotype on blood pressure seems to be conveyed through its effects on BMI and W/H. Transient expression of the SA protein in mammalian cells confirmed that it is expressed in mitochondria and has medium-chain fatty acid:CoA ligase activity. The A/G polymorphism was found to be associated with the expression level of SA mRNA in peripheral mononuclear cells in vivo.The G allele of SAH was found to be associated with multiple risk factors, including hypertriglyceridemia, hypercholesterolemia, obesity, and hypertension. This observation should open a new area for future research in multiple-risk-factor syndromes.
THE RESISTANCE TO FIBRINOLYTIC ACTIVITY OF THE HEMOLYTIC STREPTOCOCCUS WITH SPECIAL REFERENCE TO PATIENTS WITH RHEUMATIC FEVER AND RHEUMATOID (ATROPHIC) ARTHRITIS 1
Authors: Walter K. Myers, Chester S. Keefer, William F. Holmes
Journal: Journal of Clinical Investigation (1935)

Recently Tillett and Garner (1) have demon- strated that broth cultures of hemolytic strepto- cocci of human origin rapidly liquefy the fibrin- clot of human plasma.Cultures of other species of bacteria obtained from human beings fail to exhibit this property.Tillett, Edwards and Garner (2) further found that the plasma clot from patients convalescent from acute hemolytic streptococcal infections was highly resistant to the action of broth cultures of a human hemo- lytic streptococcus.The observations of Tillett and his coworkers were confirmed by Hadfield, Magee and Perry (3).Previously, we (4, 5, 6) have studied groups of patients with rheumatic fever and rheumatoid arthritis to determine what, if any, relationship exists between streptococcal infection and these diseases.In continuing these studies, we have determined the resistance to fibrinolysis of the blood plasma of patients with rheumatic fever and rheumatoid arthritis and of control groups of patients.
Does Lower Diabetes-Related Numeracy Lead to Increased Risk for Hypoglycemic Events?
Authors: Kerri Cavanaugh
Journal: Annals of Internal Medicine (2008)

Letters21 October 2008Does Lower Diabetes-Related Numeracy Lead to Increased Risk for Hypoglycemic Events?Kerri Cavanaugh, MD, MHS and Russell L. Rothman, MD, MPPKerri Cavanaugh, MD, MHSFrom Vanderbilt University Medical Center, Nashville, TN 37232.Search for more papers by this author and Russell L. Rothman, MD, MPPFrom Vanderbilt University Medical Center, Nashville, TN 37232.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-8-200810210-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that interventions to reduce the frequency and severity of hypoglycemic episodes in patients are an integral component of diabetes care and patient safety. Patient literacy and numeracy may play an important role in adverse events related to blood sugar management. For a subgroup of patients in our study (n = 163 [41% of the primary sample]), we were able to download data from their blood glucose meters and obtain information about the frequency of hypoglycemic events (defined as blood glucose level <3.33 mmol/L [<60 mg/dL]) and the proportion of blood glucose measures less than 3.89 mmol/L (<70 ... Author, Article, and Disclosure InformationAuthors: Kerri Cavanaugh, MD, MHS; Russell L. Rothman, MD, MPPAffiliations: From Vanderbilt University Medical Center, Nashville, TN 37232.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation of Numeracy and Diabetes Control Kerri Cavanaugh , Mary Margaret Huizinga , Kenneth A. Wallston , Tebeb Gebretsadik , Ayumi Shintani , Dianne Davis , Rebecca Pratt Gregory , Lynn Fuchs , Robb Malone , Andrea Cherrington , Michael Pignone , Darren A. DeWalt , Tom A. Elasy , and Russell L. Rothman Does Lower Diabetes-Related Numeracy Lead to Increased Risk for Hypoglycemic Events? Urmimala Sarkar and Dean Schillinger Metrics 21 October 2008Volume 149, Issue 8 Page: 594 Keywords Blood Glucose Hypoglycemics Literacy Numeracy Safety Safety studies Serious adverse events Type 1 diabetes Type 2 diabetes ePublished: 21 October 2008 Issue Published: 21 October 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Fluorescent Antibody Technique for Cryptococcus
Authors: Glenn D. Roberts
Journal: JAMA (1974)

To the Editor.—  In the Nov 19,1973, issue ofThe Journal(226:1009, 1973), Dr. Paul Wolf of Stanford University had a letter published purporting to describe a new method to identify cryptococcal infection.  In all fairness to Dr. R. A. Vogel, you should be aware that he reported this method initially in 1958 and again in 1961 and 1966. Some of the publications in this area are presented. 1-4   I think this should be brought to the attention of your readers so that the primary investigator receives credit for his work.
Sympathetic Activation by Sildenafil
Authors: Bradley G. Phillips, Masahiko Kato, Catherine A. Pesek, Mikolaj Winnicki, Krzysztof Narkiewicz, Diane Davison, Virend K. Somers
Journal: Circulation (2000)

Background —Sildenafil citrate is an effective and widely prescribed therapy for erectile dysfunction. Little is known about the effects of sildenafil on neural control of the circulation or about the effects of sildenafil on neurocirculatory stress responses. Methods and Results —We studied 14 normal volunteers (age 32±7 years) who were randomized in a double-blind crossover fashion to receive a single oral dose of sildenafil 100 mg or placebo on 2 separate study days. Blood pressure, heart rate, forearm vascular resistance, muscle sympathetic nerve activity, and plasma catecholamines were measured at baseline and at 30 and 60 minutes after sildenafil and after placebo administration. The effects of sildenafil and placebo on neural and circulatory responses to stressful stimuli (sustained handgrip, maximal forearm ischemia, mental stress, and the cold pressor test) were also evaluated. Blood pressure, heart rate, and forearm vascular resistance after sildenafil and placebo were similar. However, muscle sympathetic nerve activity increased strikingly after sildenafil (by 141±26%, mean±SEM) compared with placebo (3±8%) ( P =0.006); plasma norepinephrine levels also increased by 31±5% after sildenafil administration ( P =0.004). Sympathetic nerve traffic during mental, physical, and cold stresses was 2- to 8-fold higher after sildenafil than with placebo ( P &lt;0.05). Conclusions —Sildenafil causes a marked increase in sympathetic activation, evident both at rest and during stressful stimuli. Sympathetic activation by sildenafil may have implications for understanding cardiovascular events associated with sildenafil use.
Fatal Neonatal Hemorrhage After Maternal Anticonvulsant Therapy
Authors: W. Archie Bleyer
Journal: JAMA (1976)

Twenty-one cases of neonatal hemorrhage after maternal anticonvulsant therapy have been reported, although only two of these have been published in American journals. We recently encountered another case, fatal despite phytonadione prophylaxis at birth and additional doses at the onset of bleeding.  ( JAMA 235:626-627, 1976)
A Prospective Study of Closed Pleural Biopsies
Authors: Joseph Scerbo
Journal: JAMA (1971)

To evaluate the usefulness of performing pleural biopsy in every patient with undiagnosed pleural disease, regardless of the presence of fluid, a total of 222 biopsies were performed in 163 patients with use of the Abrams needle technique. In the last 48 specimens, culture in 7H-9 liquid medium was routinely performed. In all biopsy specimens, pleural disease was found. In 61 instances, a specific histological diagnosis of either neoplasia or tuberculosis was made. In 80% of the biopsy specimens with histological evidence for tuberculosis, the cultures of the specimens were positive. Thirty-five biopsies were done in the absence of pleural fluid and were as diagnostically successful as those done in the presence of fluid. Pleural biopsy is indicated in any case of undiagnosed pleural disease, even if free fluid is not present.
Improving the Drug Development Process
Authors: Benjamin Djulbegovic, Iztok Hozo, John P. A. Ioannidis
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3: Imaging of stromal cells during hepatocellular metastasis formation in the RFP-MUP-uPA mouse
Authors: Atsushi Suetsugu, Hisanobu Ogata, Yukihiko Hiroshima, Masashi Momiyama, Yosuke Osawa, Hisataka Moriwaki, Shigetoyo Saji, Michael Karin, Robert M. Hoffman
Journal: Cancer Research (2014)

Abstract Major urinary protein-urokinase type plasminogen activator (MUP-uPA) transgenic mice develop liver disease. We have developed the RFP-MUP-uPA mice, by crossing MUP-uPA mice with transgenic mice ubiquitously-expressing RFP. Hepatocyte RFP fluorescence in this model is very strong. In addition, RFP fluorescence of stromal cells is very bright enabling the portal vein and sinusoid structures to be clearly visualized. Huh7 liver cancer cells expressing green fluorescent protein (GFP) were injected in the spleen of MUP-uPA transgenic mice. The vessels of the MUP-uPA liver are filled with Huh7-GFP cells as imaged in live mice 3h after cell injection. Huh7-GFP cells formed tumor colonies in the liver 28 days after cell transplantation to the spleen. The Huh7-GFP cells were visualized in the liver with the Olympus FV1000 confocal microscope. In large metastatic liver tumors in RFP-MUP-uPA mice, stroma cells derived from the host animal appeared around and into the edge of Huh7-GFP tumors. In contrast, in small metastatic liver tumors, there were no stromal cells observed. The stromal cells were observed in the spleen primary tumor, as well as kidney and the lung metastasis in addition to the large liver tumors. This model enables imaging the effects of uPA on liver metastasis and stromal recruitment enabling the metastasis to progress. Citation Format: Atsushi Suetsugu, Hisanobu Ogata, Yukihiko Hiroshima, Masashi Momiyama, Yosuke Osawa, Hisataka Moriwaki, Shigetoyo Saji, Michael Karin, Robert M. Hoffman. Imaging of stromal cells during hepatocellular metastasis formation in the RFP-MUP-uPA mouse. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3. doi:10.1158/1538-7445.AM2014-3
"Case finding" in dementia is simply screening with no evidence of benefit
Authors: M. McCartney
Journal: BMJ (2014)

<h3>Summary</h3> Many surgeons consider repeat endoscopy to be the standard of care for colorectal cancer; however, its utility in the preoperative setting is not well understood, especially given the lack of standardized guidelines on appropriate tumour localization and colonoscopic reporting. This often results in patients undergoing an unnecessary medical procedure during their preoperative evaluation. We discuss some of the issues surrounding the practice of preoperative repeat endoscopy as well as patient perspectives on the procedure. Our observations suggest that repeat endoscopy in the setting of colorectal cancer surgery may play a role in enabling transition of patient care between the initial endoscopist and the treating surgeon and in improving the patient experience. Patients with operable colorectal cancer appear to understand and support the current use of repeat endoscopy. However, improving preoperative care will require further research and ultimately the development of evidence-based clinical guidelines.
Learning from low income countries: what are the lessons?: Communities improve health systems
Authors: Masamine Jimba, Susumu Wakai
Journal: BMJ (2004)

<h3>Abstract</h3> Hedgehog (HH) signalling plays a key role in embryonic pattering and stem cell differentiation. Compounds that selectively bind Smoothened (SMO) can induce cell death in mouse embryonic stem cells (ESCs). Here we perform a genetic screen in haploid ESCs and discover that SMO inhibits a cell death pathway that resembles dissociation induced death of human ESCs and Anoikis. In mouse ESCs, SMO acts through a G-protein coupled mechanism that is independent of GLI activation. Our screen also identifies the Golgi proteins Tmed2 and Tmed10. We show that TMED2 binds SMO and controls its abundance at the plasma membrane. In neural differentiation and neural tube pattering Tmed2 acts as a repressor of HH signalling strength. We demonstrate that the interaction between SMO and TMED2 is regulated by HH signalling suggesting SMO release form the ER-Golgi is critical for controlling G-protein and GLI mediated functions of mammalian HH signalling.
107 INSULIN RESISTANCE, SERUM ADIPOKINES AND THE RISK OF FIBROSIS PROGRESSION IN PATIENTS TRANSPLANTED FOR HEPATITIS C: A PROSPECTIVE COHORT STUDY
Authors: B.J. Veldt, J.J. Poterucha, K.D.S. Watt, R.H. Wiesner, J.E. Hay, C.B. Rosen, J.K. Heimbach, H.L.A. Janssen, M.R. Charlton
Journal: Journal of Hepatology (2008)
Diagnostic value of confocal endomicroscopy in celiac disease
Authors: U. Günther, S. Daum, F. Heller, M. Schumann, C. Loddenkemper, M. Grünbaum, M. Zeitz, C. Bojarski
Journal: Endoscopy (2010)

See also: Commentaire de travail de C. Katada et al., pp. 185Endoscopy 2010; 42(03): 241-241DOI: 10.1055/s-0031-1291840
Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals
Authors: Lela Kardava, Susan Moir, Naisha Shah, Wei Wang, Richard Wilson, Clarisa M. Buckner, Brian H. Santich, Leo J.Y. Kim, Emily E. Spurlin, Amy K. Nelson, Adam K. Wheatley, Christopher J. Harvey, Adrian B. McDermott, Kai W. Wucherpfennig, Tae-Wook Chun, John S. Tsang, Yuxing Li, Anthony S. Fauci
Journal: Journal of Clinical Investigation (2014)

Recently, several neutralizing anti-HIV antibodies have been isolated from memory B cells of HIV-infected individuals. Despite extensive evidence of B cell dysfunction in HIV disease, little is known about the cells from which these rare HIV-specific antibodies originate. Accordingly, we used HIV envelope gp140 and CD4 or coreceptor (CoR) binding site (bs) mutant probes to evaluate HIV-specific responses in peripheral blood B cells of HIV-infected individuals at various stages of infection. In contrast to non-HIV responses, HIV-specific responses against gp140 were enriched within abnormal B cells, namely activated and exhausted memory subsets, which are largely absent in the blood of uninfected individuals. Responses against the CoRbs, which is a poorly neutralizing epitope, arose early, whereas those against the well-characterized neutralizing epitope CD4bs were delayed and infrequent. Enrichment of the HIV-specific response within resting memory B cells, the predominant subset in uninfected individuals, did occur in certain infected individuals who maintained low levels of plasma viremia and immune activation with or without antiretroviral therapy. The distribution of HIV-specific responses among memory B cell subsets was corroborated by transcriptional analyses. Taken together, our findings provide valuable insight into virus-specific B cell responses in HIV infection and demonstrate that memory B cell abnormalities may contribute to the ineffectiveness of the antibody response in infected individuals.
AMPLIFICATION OF THE MYOCARDIAL INFARCT SIZE LIMITING EFFECTS OF EXENATIDE WITH CILOSTAZOL, A PHOSPHODIESTERASE III INHIBITOR
Authors: Yochai Birnbaum, Alexander C. Castillo, Ling Shukuan, Mandeep Bajaj, Jose R. Perez-Polo, Yumei Ye
Journal: Journal of the American College of Cardiology (2012)
Importance of the Primer for Practicing Internists, Internal Medicine Residents, and Medical Students
Authors: E. A. Hildreth
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Raynaud's Phenomenon-Reply
Authors: Geza de Takats
Journal: JAMA (1962)

<h3>To the Editor:—</h3> We are grateful to Drs. Gifford and Hines for their comments on our paper. Their group has studied Raynaud's phenomenon for many years. Actually, when one studies their carefully documented papers, with which we are well familiar, one finds considerable data disproving their, and confirming our, contention. Thus, in 12% of their patients, trophic lesions occurred after sympathectomy. In one, the case reports, "Raynaud's disease" was present for 23 years before stellate ganglionectomy. Six years after the operation, ulceration of fingers developed "in spite of complete denervation." These authors do recognize that secondary Raynaud's phenomenon shows poor results from sympathectomy in 72% of the cases; 35% of them were dead at the time of follow-up. The crux of the situation in our view, is whether or not one is capable of differentiating Raynaud's disease with sclerodactylia from early diffuse scleroderma with Raynaud's phenomenon. One is, of course,
Medical Costs in Relation to the Organization of Ambulatory Care
Authors: Milton I. Roemer, Donald M. DuBois
Journal: New England Journal of Medicine (1969)

RISING costs of medical care are a worldwide phenomenon, and everywhere they have induced a search for methods of improved economy and efficiency. The rise in costs is real, even after correction for general price inflations. Partly, of course, the rise is due to an increase in the volume of medical services provided or, as it is usually put, the medical-care utilization rate of the population. Since expanding social expectations regard this as desirable (that is, to apply science to human need), the search for economies is seldom expressed in an effort to reduce the rate of ambulatory services provided, . . .
Socioeconomic Disparities in Preventive Care Persist Despite Universal Coverage
Authors: Steven J. Katz
Journal: JAMA (1994)

To compare the association of income and education with breast and cervical cancer screening in Ontario, Canada, and the United States.Survey using data from the Ontario Health Survey and the US National Health Interview Survey.A multistage random sample of women aged 18 years and older living in households in Ontario (N = 23,521) and the United States (N = 23,932) in 1990.Persons were considered screened if they reported a Papanicolaou test within the previous 2 years, a clinical breast examination within the previous year, or a mammogram within the previous year.Papanicolaou test and clinical breast examination rates were similar between countries, but mammography rates were two to three times higher in the United States across all age groups. Compared with women with less than a high school degree, college graduates were more likely to receive screening (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.2 to 1.7) and there was no difference between countries. Across all procedures, women with higher incomes were more likely to receive screening. For Papanicolaou test and clinical breast examination, there was no difference between countries. Compared with the lowest income, the OR was 1.7 (95% CI, 1.3 to 2.1) in Ontario and 1.9 (95% CI, 1.6 to 2.2) in the United States for Papanicolaou test and 2.1 (95% CI, 1.6 to 2.8) in Ontario and 2.1 (95% CI, 1.8 to 2.6) in the United States for the clinical breast examination for women with income greater than $45,600 (US dollars). For mammography screening, the association of income with use was greater in the United States: the OR was 1.8 (95% CI, 1.3 to 2.6) in Ontario and 2.7 (95% CI, 2.3 to 3.2) in the United States for women with income greater than $45,600 (US dollars).Despite the long-time presence of universal insurance coverage in Ontario the disparities in the use of cancer screening procedures by the poor were similar to the United States. Universal coverage is not sufficient to overcome the large disparities in screenings across socioeconomic status demonstrated in both countries.