A Clinical Evaluation of the D-Xylose Tolerance Test
Authors: JOHN M. FINLAY
Journal: Annals of Internal Medicine (1964)

Article1 September 1964A Clinical Evaluation of the D-Xylose Tolerance TestJOHN M. FINLAY, M.D., F.R.C.P. (C), F.A.C.P., JEAN HOGARTH, M.D., F.R.C.P. (C), KEITH J. R. WIGHTMAN, M.D., F.R.C.P. (C), F.A.C.P.JOHN M. FINLAY, M.D., F.R.C.P. (C), F.A.C.P.Search for more papers by this author, JEAN HOGARTH, M.D., F.R.C.P. (C)Search for more papers by this author, KEITH J. R. WIGHTMAN, M.D., F.R.C.P. (C), F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-3-411 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe xylose tolerance test has been the subject of much investigative work and interest. Its application to the study of the malabsorption syndrome has been described in previous publications (1-14). A flattened blood curve and low renal xylose excretion characterizes the test response in active untreated idiopathic sprue in adults (7). In secondary steatorrhea, the blood curve and renal xylose excretion are usually normal unless the small bowel is excluded or extensively involved by disease (7, 9).The data on which this paper is based include test responses observed in a group of illnesses in which defects in metabolism and...References1. FOURMAN LP: Absorption of xylose in steatorrhea. Clin. Sci. 6: 289, 1948. MedlineGoogle Scholar2. TURNER DA: Absorption from the Intestine. M.Sci. Thesis, University of Western Ontario, London, Ontario, 1950. Google Scholar3. BRIENTURNERWATSONGEDDES FSDAEMJH: A study of carbohydrate and fat absorption from the normal and diseased intestine in man. Gastroenterology. 20: 287, 1952. CrossrefMedlineGoogle Scholar4. ALTHAUSEN TL: A test for intestinal absorption. Amer. J. Dig. Dis. 6: 544, 1939. CrossrefGoogle Scholar5. BENSONCULVERRAGLANDJONESDRUMMEYBOUGAS JAPJSCMGDE: The d-xylose absorption test in malabsorption syndrome. New Eng. J. Med. 256: 335, 1957. 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Gastroenterology. 41: 24, 1961. CrossrefGoogle Scholar25. ALTHAUSENSTOCKHOLM TLM: Influence of the thyroid gland on absorption in the digestive tract. Amer. J. Physiol. 123: 577, 1938. CrossrefGoogle Scholar26. HELMERFOUTS OMPJ: Gastrointestinal studies; vii, excretion of xylose in pernicious anemia. J. Clin. Invest. 16: 343, 1937. CrossrefMedlineGoogle Scholar27. BEZMANKINNEARZAMCHEK ADGN: D-Xylose and potassium iodide absorption and serum carotene in pernicious anemia. J. Lab. Clin. Med. 53: 226, 1959. MedlineGoogle Scholar28. KIPNISCORI DMCF: Studies of tissue permeability. III. The effect of insulin on pentose uptake by the diaphragm. J. Biol. Chem. 224: 681, 1957. CrossrefMedlineGoogle Scholar29. HELMREICHCORI ECF: Studies of tissue permeability. II. The distribution of pentoses between plasma and muscle. Ibid., p. 663. Google Scholar30. FIELDJOHNSON JBP: Effect of insulin on d-xylose disappearance in diabetic patients. J. Appl. Physiol. 15: 979, 1960. CrossrefMedlineGoogle Scholar31. PERMANGULLBERGERREIZENSTEINSNELLMANALLGÉN GRPGBL: A study of absorption patterns in malabsorption syndromes. Acta Med. Scand. 168: 117, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN M. FINLAY, M.D., F.R.C.P. (C), F.A.C.P.; JEAN HOGARTH, M.D., F.R.C.P. (C); KEITH J. R. WIGHTMAN, M.D., F.R.C.P. (C), F.A.C.P.Affiliations: Toronto, Ontario,From the Department of Medicine, Toronto General Hospital and University of Toronto.This work was supported by grants from the Medical Research Council of Canada.Requests for reprints should be addressed to John M. Finlay, M.D., 430 Medical Arts Building, Toronto 5, Ontario, Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by13 C-xylose and 14 C-xylose breath tests for the diagnosis of coeliac diseaseComparison of D-Xylose Hydrogen Breath Test With Urinary D-Xylose Test in Indian Children With Celiac DiseaseUtilisation d'une épreuve couplée au lactulose-mannitol-xylose pour évaluer les fonctions intestinales des sujets âgésD-xylose TestingGLP-2 augments the adaptive response to massive intestinal resection in ratBiochemical Tests in Diseases of the Intestinal Tract: Their Contributions to Diagnosis, Management, and Understanding the Pathophysiology of Specific Disease StatesFollow-up of celiac disease withd-xylose breath testIntestinal function and injury in acquired immunodeficiency syndrome—related cryptosporidiosisClinical applicability of shortenedd-Xylose breath test for diagnosis of intestinal malabsorptionIleal Digestibility and Urinary Excretion of D-Xylose and L-Arabinose in Ileostomized Adult RoostersEffects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary studyd-Xylose absorption testLaboratory Diagnosis of MalassimilationGastrointestinal Dysfunction in Systemic Mastocytosisd-Xylose testing: A reviewProtein requirements of a group of chronic alcoholics: Efficiency of duodenal amino acid infusionThe Diagnostic Value of the D-Xylose Absorption Test in Adult Coeliac DiseaseMalabsorption in adults: Etiology, evaluation, and managementEffect of Renal Disease on Pharmacokinetics and BioavailabilityMalassimilationssyndrom (Maldigestion — Malabsorption)A pathophysiologic approach to diagnosis of malabsorptionNormal and abnormal intestinal absorption by humansDiarrhea after gastrectomy and vagotomyOne-hour blood xylose test: A reliable index of small bowel functionTests of Small-Intestinal Function — Digestion, Absorption, SecretionGrowth of chick and mammalian cells on d-xyloseTests of intestinal functionXylose absorption and its clinical significanceLimitations of xylose tolerance test as a screening procedure in childhood coeliac disease.The occurrence of cystic fibrosis and celiac sprue within a single sibshipXylose absorption test using D-xylose-14CThe Biochemical Aspects of Protein-Calorie MalnutritionDifferential Diagnostic Approach to Clinical Problems of MalabsorptionIntestinale Absorptionsst�rung infolge metforminbehandlung (Zur Frage der Wirkungsweise der Bignanide)Distribution of D-Xylose in Sequestered Fluid Resulting in False-Positive Tests for MalabsorptionGEOBEL A. MARIN, M.D., MICHAEL L. CLARK, M.B., M.R.C.P., JOHN R. SENIOR, M.D., F.A.C.P.INVESTIGATION OF STEATORRHOEAPhysiologic alterations in small bowel function with ageDISACCHARIDASE DEFICIENCY IN REGIONAL ENTERITISBile-Salt Deficiency in the Steatorrhea Following Resection of the Ileum and Proximal ColonRecognition and Treatment of Intestinal IschemiaGluten Enteropathy Appearing After Gastric SurgeryMalabsorptionThe Study of Carbohydrate MetabolismCholecystocolonic Fistula with MalabsorptionLOUIS J. ELSAS, M.D., TUVIA GILAT, M.D. 1 September 1964Volume 61, Issue 3Page: 411-422KeywordsBloodDiarrheaExcretionHematologic testsHospital medicineInflammatory bowel diseaseRenal diseasesRenal physiologySteroid therapyXylose ePublished: 1 December 2008 Issue Published: 1 September 1964 PDF downloadLoading ...