tbuckley/cabot-search huggingface dataset:
CETP Inhibition Shows Promise as Way to Reduce Cardiovascular Disease Risk
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological Weapons and US Law
Authors: James R. Ferguson
Journal: JAMA (1997)

During the past 8 years, the US Congress has developed a comprehensive legal framework to prevent the illegitimate use of toxins and infectious agents. As part of this framework, Congress has defined as a federal crime virtually every step in the process of developing or acquiring a biological agent for use as a weapon. At the same time, Congress has vested federal law enforcement agencies with broad civil and investigative powers to enable the government to intervene before such weapons are used or even developed. Finally, Congress has directed the Centers for Disease Control and Prevention to establish a regulatory regime to monitor the location and transfer of hazardous biological agents and to insure that any use of such agents complies with appropriate biosafety requirements.
Multiple Approach to the Exploration of Genotype-Phenotype Correlations in Familial Adenomatous Polyposis
Authors: L. Bertario, A. Russo, P. Sala, L. Varesco, M. Giarola, P. Mondini, M. Pierotti, P. Spinelli, P. Radice
Journal: Journal of Clinical Oncology (2003)

Purpose: Familial adenomatous polyposis (FAP), caused by a mutation in the APC gene, is a colorectal cancer predisposition syndrome associated with several other clinical conditions. The severity of the FAP is related to the position of the inherited mutation in the APC gene. We analyzed a large series of FAP patients to identify associations among major clinical manifestations and to correlate the mutation site with specific disease manifestations. Materials and Methods: APC mutations were identified in 953 FAP patients from 187 families. We used unconditional logistic regression models and a method involving generalized estimating equations to investigate the association between genotype and phenotype. We used multiple correspondence analysis to represent the interrelationships of a multiway contingency table of the considered variables. Results: APC germline mutations were located between codons 156 and 2011 of the APC gene. Mutations spanning the region between codons 543 and 1309 were variable, but strongly associated with congenital hypertrophy of retinal pigment epithelium. Mutations between codons 1310 and 2011 were associated with a six-fold risk of desmoid tumors relative to the low-risk reference region (159 to 495). Mutations at codon 1309 were associated with early development of colorectal cancer. Mutations between codons 976 and 1067 were associated with a three- to four-fold increased risk of duodenal adenomas. The cumulative frequency of extracolonic manifestations was highest for mutations between codons 976 and 1067, followed by mutations between 1310 and 2011. Conclusion: Analysis of the relation between APC mutation site and phenotype identifies subgroups of FAP patients at high risk for major extracolonic disease, which is useful for surveillance and prevention.
Early cyclosporine monotherapy in liver transplantation: A 5-year follow-up of a prospective, randomized trial
Authors: Luca S. Belli, Luciano de Carlis, Gianfranco Rondinara, Alberto B. Alberti, Giorgio Bellati, Andrea De Gasperi, Domenico Forti, G. Idèo
Journal: Hepatology (1998)

Maintenance of adequate immunosuppression and avoidance of side-effects are the goals of long-term management of all organ-transplanted patients. We here report the final results of a prospective, randomized trial comparing early cyclosporine monotherapy versus double-drug therapy (cyclosporine and steroids) in adult liver transplantation patients. One hundred four patients were randomized 3 months after transplantation either to continue (Group I = 50 patients) or to stop steroids (Group II = 54 patients). Patients on a double-drug regimen were maintained long term on methylprednisolone at a dose of 0.1 mg/kg/d. Target cyclosporine trough levels were between 150 and 250 ng/mL in both groups. Our main points of interest were the prevalence of acute and chronic rejections and steroid-related side-effects in the two groups of patients. Mean follow-up was 41 ± 16 months (range, 4-68 months). Patient actuarial survival 2 and 5 years after randomization was similar in the two groups (82% vs. 83% and 82% vs. 77%). The prevalence of acute rejections after randomization was, respectively, 8% and 4%. A single episode of chronic rejection was observed only in a patient on long-term steroid therapy. Side-effects of steroid therapy were less frequent in patients weaned off steroids, and when considering hypertension and diabetes, the differences between the two groups were statistically significant. Early cyclosporine monotherapy is a safe undertaking in liver transplantation because it allows a significant reduction of steroid-related side-effects without increasing the risk of acute and chronic rejection. After 5 years, patient survival was similar in patients with or without steroids.
In Opposition to Woman Doctors in Insane Asylums.
Authors: W. W. Parker
Journal: JAMA (1894)

<h3>"To the Editor of the Dispatch:</h3> " A fair writer in the<i>Times</i>recently made quite a free use of my name, motives, intelligence, etc., in reference to the ' Woman Doctor ' in the insane asylums. The gentleman from whom she received her information of the night's session of the Committee on Asylums has done me injustice, of course not by design. I said: ' There were one or two mean, venal doctors (men, of course), in Richmond, I would like to send to the penitentiary for violating law, but if a woman doctor violated law it would not be for money, but from kind womanly sympathy.' I sent the fair correspondent a copy of my pamphlet on 'Woman's Place,' which I hope she will be kind enough to read, and I will be glad to have her criticism, either private or public. I also refer her to my
THE UTILIZATION OF CARBOHYDRATES IN A CASE OF CHRONIC PENTOSURIA
Authors: I. M. Rabinowitch
Journal: Journal of Clinical Investigation (1926)

Recently an opportunity was afforded for a brief study of the car- bohydrate and respiratory metabolism in a case of chronic pentosuria.Simultaneous blood sugar and respiratory quotient time curves were obtained following ingestion of glucose as described hereafter.As far as can be ascertained from the literature, such observations, in this rare disease, have not been recorded hitherto.The subject, a male, aged 40, applied recently for a life assurance policy, and was rejected because sugar was found in his urine.Otherwise he was perfectly well and there were no signs suggesting diabetes mellitus.The applicant failed to mention the fact to the medical examiner, that he had had sugar in his urine since 1904 (for 22 years), at which time it was discovered accidentally, also during a life assur- ance examination.He also failed to present a letter (which he did to the author), given him by his physician at that time, showing that a diagnosis of pentosuria had been made.
Is Inherited Syphilis Protective against Subsequent Contagion?
Authors: C. F. Maunder
Journal: BMJ (1861)

May Gth.The foot and leg were swolleni and red.Erysipelas had come on: the attack turned out a very bad one, the inflammation spreading up the thigh and over the abdomen.For several days the boy was in considerable danger, and for nearly a nmonth all local treatmenit had to be suspended.June 3rd.Local treatment of tihe original disea.sew-as resumed.The wound had nearly closed; but it did not seem advisable to irmake a fresh opening.A tlicik
Funding of Clinical Trials
Authors: Steven Borzak
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation
Authors: Tony Bruns, Henning W. Zimmermann, Annette Pachnio, Ka-Kit Li, Palak J. Trivedi, Gary Reynolds, Stefan Hubscher, Zania Stamataki, Paul W. Badenhorst, Christopher J. Weston, Paul A. Moss, David H. Adams
Journal: Journal of Hepatology (2015)
Conduction Disorders in the Canine Proximal His-Purkinje System Following Acute Myocardial Ischemia
Authors: NABIL EL-SHERIF, BENJAMIN J. SCHERLAG, RALPH LAZZARA
Journal: Circulation (1974)

The evolution of bilateral bundle branch block (BBB) was studied in ten anesthetized dogs by recording electrical activity from the bundle of His (Hb), right (Rb) and left bundles (Lb) for precise localization and characterization of the conduction disorder. Records were obtained before and at intervals up to 8 hours after ligation of the anterior septal artery. Forty to 140 min after ligation conduction was impaired in either the Rb or Lb showing complete BBB both at rapid heart rates (tachycardia-dependent) and slow rates (bradycardia-dependent) with normal QRS or incomplete BBB at control rates. Later complete BBB became constant at all heart rates. When both bundles were significantly involved, various combinations of intraventricular and atrioventricular conduction disorders occurred. Unequal delay in both bundles (unequal 1° bilateral BBB) gave rise to prolonged H-V interval and a QRS pattern of incomplete or complete bundle branch block corresponding to the branch in which the conduction delay was greater. Equal delay in both bundles gave rise to a narrow QRS with prolonged H-V interval. Second degree block in one bundle and complete (3°) block in the other manifested as 2:1, Mobitz type II, or Wenckebach A-V conduction disturbance. Unequal and asynchronous 2° bilateral BBB gave rise to complex patterns of alternating BBB associated with alteration in the H-V interval of 25-35 msec. In two experiments showing alternating BBB, longitudinal dissociation and asynchronous conduction in the distal Hb was suggested.
The Medical Welfare Dollar
Authors: G. G. Liddle
Journal: JAMA (1967)

<h3>To the Editor:—</h3> In line with your editorial about the welfare state and the physician (<b>201</b>:320, 1967) the Bureau of Engraving and Printing should issue a special Tax Proof Doctor's Dollar, for the exclusive use of physicians and nurses, but not of osteopaths, medical librarians, or shoe salesmen. Congress would allot these to all practicing physicians without limitation in number. They would be valid for his income taxes, fishing licenses, gasoline bills, convention expenses, and dues to the American Medical Association. The vignette should portray William Osler, against a background of atomic energy liver scans.
When my daughter sailed home
Authors: M. E Black
Journal: BMJ (2009)

At the European Optimist sailing championship in Strunjan, Slovenia, this June, 250 children from 40 countries competed for six days on the wide, wide sea. I was a proud “OptiMum” with two children in the Serbian national team. “Oppies” are the boats in which the world learns to sail. Children are captains of their own ship. Competing is about winning; but more importantly it is about gaining a love for sailing and learning life lessons.

There we were, of all nationalities, waving our children off from the shore. I thought …
Non-Suppurative Intracranial Complications of Otitis Media
Authors: A. A. McConnell
Journal: BMJ (1937)

CEREBRAL OEDEMA IN CERTAIN MENTAL DISORDERS MECBR'INTS 659glycerol, by sulphur when this element is deficient, and by calcium salts, according to the laboratory findings and the nature of the case.Summary An abnormal condition of the serum is described which, when persistent, is nearly always associated with signs of pancreatic inflammation: this inflammation is generally ascending from the intestine, and is patchy in distribution.Glycosuria is rare.Insulin is ineffective.The altered blood state predisposes to oedema and to low-grade infections.My thanks are due to Dr. Porter Phillips;
661 COMPARISON OF HCV-ASSOCIATED GENE EXPRESSION AND CELL SIGNALING PATHWAYS IN CELLS WITH OR WITHOUT HCV REPLICON AND IN REPLICON-CURED CELLS
Authors: Y. Nishimura-Sakurai, N. Sakamoto, K. Mogushi, S. Nagaie, M. Nakagawa, Y. Itsui, M. Tasaka-Fujita, Y. Onuki-Karakama, G. Suda, K. Mishima, M. Yamamoto, M. Ueyama, Y. Funaoka, T. Watanabe, S. Azuma, Y. Sekine-Osajima, S. Kakinuma, N. Enomoto, H. Tanaka, M. Watanabe
Journal: Journal of Hepatology (2010)
61 Fluticasone propionate once daily is as effective as beclomethasone dipropionate twice daily for perennial allergic rhinitis
Authors: A VANAS, E BRONSKY, P CHERVINSKY, R DOCKHORN, C FURUKAWA, J GROSSMAN, R LOCKEY, W LUMRY, E MELTZER, R NATHAN
Journal: Journal of Allergy and Clinical Immunology (1991)
Evaluating insulin secretagogues in a humanized mouse model with functional human islets
Authors: Jian Luo, Kathy Nguyen, Michael Chen, Than Tran, Jianqiang Hao, Bole Tian, Ingrid C. Rulifson, Ying Zhang, Lei Tian, Yu Zhang, Edwin Lopez, Daniel C.-H. Lin, Yingcai Wang, Zhihua Ma, Jonathan Houze, Zhiguang Guo
Journal: Metabolism (2012)
Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen
Authors: Mei-Hwei Chang, Hong-Yuan Hsu, Yen-Hsuan Ni, Keh-Sung Tsai, Ping-Ing Lee, Pei-Jer Chen, Ya-Ling Hsu, Ding-Shinn Chen
Journal: Journal of Hepatology (1998)
Embryonic Specimens Wanted.
Authors: Franklin P. Mall
Journal: JAMA (1897)

Baltimore, Md., Feb. 20, 1897. <h3>To the Editor:</h3> —During the last ten years I have appealed to physicians from time to time to send me the human embryos which fell into their hands, and have in this way procured some very valuable specimens. These specimens have been cut into sections, and are now being modeled and studied very carefully. Yet a number of important stages are still wanting, and I therefore ask through your columns that physicians send me any material which they may obtain. The best method to preserve human ova is to place the unopened ovum, without handling, and as soon as possible, in strong alcohol. By this method the embryo within is well hardened for future microscopic study. It is very injurious to wrap these delicate specimens in cotton before sending them by mail or express. A perfect method is to place the preserved specimen in a
Familial pityriasis rotunda in black-skinned patients; a first report
Authors: A.C. Friedmann, M. Ameen, V.J. Swale
Journal: British Journal of Dermatology (2007)

Journal Article Familial pityriasis rotunda in black‐skinned patients; a first report Get access A.C. Friedmann, A.C. Friedmann Department of Dermatology, Royal Free Hospital, Pond Street, London NW3 2XA, U.K. E‐mail: adamfriedmann@yahoo.co.uk Search for other works by this author on: Oxford Academic Google Scholar M. Ameen, M. Ameen Department of Dermatology, Royal Free Hospital, Pond Street, London NW3 2XA, U.K. E‐mail: adamfriedmann@yahoo.co.uk Search for other works by this author on: Oxford Academic Google Scholar V.J. Swale V.J. Swale Department of Dermatology, Royal Free Hospital, Pond Street, London NW3 2XA, U.K. E‐mail: adamfriedmann@yahoo.co.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 6, 1 June 2007, Pages 1365–1366, https://doi.org/10.1111/j.1365-2133.2007.07874.x Published: 01 June 2007
Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic disease
Authors: Unsong Oh, Matthew J. McCormick, Dibyadeep Datta, Richard V. Turner, Kathryn Bobb, Dileep D. Monie, D. Robert Sliskovic, Yuetsu Tanaka, Jie Zhang, Jeffrey Meshulam, Steven Jacobson
Journal: Blood (2011)
809-1 Different Respiratory Rates Affect the Measurement of Autonomic Tone by Power Spectral Analysis of Heart Rate Variability in Patients with Heart Failure
Authors: John E. Sanderson, Dickens T.K. Yeung, Leata Y.C. Yeung, Richard L.G. Kay, Brian Tomlinson, Luciano Bernardi, Kam S. Woo
Journal: Journal of the American College of Cardiology (1995)
Blood pressure in first 10 years of life: the Brompton study.
Authors: M. de Swiet, P. Fayers, E. A. Shinebourne
Journal: BMJ (1992)

OBJECTIVES--To determine the normal range of blood pressure and its pattern of change in the first 10 years of life. To estimate at what age (if any) children consistently appear in one part of the blood pressure distribution and at what age familial correlations in blood pressure become significant. DESIGN--Longitudinal cohort study. SETTING--South east England. SUBJECTS--2088 children of both sexes born consecutively in Farnborough Hospital, Kent, and their parents. MAIN OUTCOME MEASURE--Blood pressure measured by Doppler ultrasonography and sphygmomanometry. RESULTS--Systolic blood pressure rose from a mean of 88.5 mm Hg at age 6 months to 96.2 mm Hg at 8 years measured with a 8 cm cuff and from 89.1 mm Hg at age 5 years to 94.3 mm Hg at age 10 years measured with a 12 cm cuff. The larger cuff gave blood pressure readings about 6 mm Hg lower. This effect was independent of body weight and arm circumference. Diastolic blood pressure rose from 57.8 mm Hg at 5 years to 61.8 mm Hg at 10 years (12 cm cuff). There was only about 1 mm Hg difference between sexes. Blood pressure was correlated with weight, weight adjusted for height, height, and arm circumference at all ages studied. The correlation coefficient of repeated yearly measurements increased steadily with age from 0.28 at 2 years to 0.59 at 10 years. The correlation coefficients between child9s blood pressure and mother9s average blood pressure increased from 0.1 at age 1 year to 0.23 at age 10. CONCLUSIONS--Blood pressure changes relatively little between the ages of 6 months and 10 years. Yet because of the increasing strength of between occasion and family correlations, children are more consistently occupying a specific part of the blood pressure distribution as they grow older. Studies in children should help determine why some adults have hypertension and others do not.
Editorial: Pulmonary embolism: where the problem is not
Authors: K. M. Moser
Journal: JAMA (1976)

There is always danger that sharply focused medical information will lead to unwarranted generalization. When examining a biopsy specimen under the microscope, we know that normal tissue in one field of view proves nothing. Cancer or other pathologic findings may be noted in the immediately adjacent field of view. Even one "normal" section does not imply that other slices are normal, and if all sections are normal, rebiopsy may yield a different result. Alpert and his colleagues (p 1477) have provided us with data focused sharply on one aspect of the panorama of venous thromboembolism. The temptation to generalize from their data must be resisted. Quoted or recalled fuzzily out of the discrete context in which they were generated, the authors' quite valid conclusions can be distorted so as to place patients in jeopardy of death due to pulmonary embolism. For example, the authors' conclusion that overall mortality caused by
Src and ADAM-17–Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL
Authors: Sandra Van Schaeybroeck, Donal M. Kelly, Joan Kyula, Susan Stokesberry, Dean A. Fennell, Patrick G. Johnston, Daniel B. Longley
Journal: Cancer Research (2008)

Abstract Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL/Apo-2L) has emerged as a promising anticancer agent. However, resistance to TRAIL is likely to be a major problem, and sensitization of cancer cells to TRAIL may therefore be an important anticancer strategy. In this study, we examined the effect of the epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) gefitinib and a human epidermal receptor 2 (HER2)–TKI (M578440) on the sensitivity of human colorectal cancer (CRC) cell lines to recombinant human TRAIL (rhTRAIL). A synergistic interaction between rhTRAIL and gefitinib and rhTRAIL and M578440 was observed in both rhTRAIL-sensitive and resistant CRC cells. This synergy correlated with an increase in EGFR and HER2 activation after rhTRAIL treatment. Furthermore, treatment of CRC cells with rhTRAIL resulted in activation of the Src family kinases (SFK). Importantly, we found that rhTRAIL treatment induced shedding of transforming growth factor-α (TGF-α) that was dependent on SFK activity and the protease ADAM-17. Moreover, this shedding of TGF-α was critical for rhTRAIL-induced activation of EGFR. In support of this, SFK inhibitors and small interfering RNAs targeting ADAM-17 and TGF-α also sensitized CRC cells to rhTRAIL-mediated apoptosis. Taken together, our findings indicate that both rhTRAIL-sensitive and resistant CRC cells respond to rhTRAIL treatment by activating an EGFR/HER2-mediated survival response and that these cells can be sensitized to rhTRAIL using EGFR/HER2-targeted therapies. Furthermore, this acute response to rhTRAIL is regulated by SFK-mediated and ADAM-17–mediated shedding of TGF-α, such that targeting SFKs or inhibiting ADAM-17, in combination with rhTRAIL, may enhance the response of CRC tumors to rhTRAIL. [Cancer Res 2008;68(20):8312–21]