tbuckley/cabot-search huggingface dataset:
Omega 3 supplements do not reduce cardiovascular risk in elderly
Authors: Z. Kmietowicz
Journal: BMJ (2014)

<h3>Abstract</h3> Honeybee (<i>Apis mellifera</i>) colony foraging decisions arise from the waggle dances of individual foragers, refined and filtered through a series of feedback loops that produce emergent collective behaviour. This process is a key example of animal communication at the height of eusociality, but a growing body of evidence suggests that its value for colony foraging success is heavily dependent on local ecology. Here, we develop a method to quantify the extent to which a colony forages collectively based on dance-decoding and show how it can be used to relate variation in collective foraging to land-use. We find that the extent to which colonies forage collectively varies across landscape types, such that it is sometimes almost entirely dominant but at other times almost negligible. By providing a means to identify the ecological conditions in which waggle dances are important on a large scale and without experimental manipulation, our methodology opens the door to exploration of the selection pressures that may have driven the evolution of this remarkable group behaviour.
Tuberculous Aortitis
Authors: Allen Silbergleit
Journal: JAMA (1965)

A total of 110 patients with tuberculosis of the aorta has been recorded in the literature. Many of these cases were diagnosed at autopsy. Aneurysm formation or perforation or both are the common complications of this condition, and treatment is surgical resection followed by antituberculosis chemotherapy. Only nine previous patients so operated on have been noted in the literature. A successful resection of a ruptured false tuberculous aneurysm of the abdominal aorta is reported. Since all patients with resected tuberculous aortic aneurysms do not have a preoperative diagnosis of tuberculosis, all resected aortic aneurysms should be carefully examined microscopically. If evidence of tuberculosis is found, antituberculosis chemotherapy should be started immediately.
Differentiation of HCV quasispecies under therapy: is it important in determining viral clearance?
Authors: Giuseppina Cappiello, Isabella Abbate, Oreste Lo Iacono, Maria R. Capobianchi, Roberta Longo, Mariacarmela Solmone, Donatella Ferraro, Giorgio Antonucci, Vito Di Marco, Antonio Craxi, Giuseppe Ippolito, Rosa Di Stefano
Journal: Journal of Hepatology (2002)
Urinary excretion of 3-methylhistidine and creatinine and plasma concentrations of amino acids in hyperthyroid patients following preoperative treatment with antithyroid drug or β-blocking agent: Results from a prospective, randomized study
Authors: Annika Adlerberth, Ulf Angeras, Rudolf Jagenburg, Göran Lindstedt, Gunnar Stenström, Per-Olof Hasselgren
Journal: Metabolism (1987)
704 MUTAGENIC AND BIOCHEMICAL EFFECTS OF RIBAVIRIN PRECEDED TO INTERFERON TREATMENT FOR PATIENTS WITH CHRONIC HEPATITIS C
Authors: K. Ogawa, S. Hige, Y. Yamamoto, M. Natsuizaka, M. Nakanishi, M. Chuma, A. Nagasaka, M. Asaka
Journal: Journal of Hepatology (2008)
Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development
Authors: Kaoru Saijo, Christian Schmedt, I-hsin Su, Hajime Karasuyama, Clifford A. Lowell, Michael Reth, Takahiro Adachi, Alina Patke, Angela Santana, Alexander Tarakhovsky
Journal: Nature Immunology (2003)
Silicone Sprays in Prevention and Treatment of Decubitus Skin Disorders in Domiciliary Nursing
Authors: J. P. W. Hughes, G. S. Wigley
Journal: BMJ (1962)

MEDIBOURNAL 153 skin.Williams et al. (1960) quote several studies in which it was shown that the wound sepsis rate was higher in patients who were nasal carriers.Adequate skin-cleansing with antibacterial agents may sterilize the skin surface, but organisms exuded from sweat and sebaceous glands may in tirne contaminate porous skin towels and the wound.Only careful exclusion of the patient's skin surface will prevent this route of entry.Lowbury and Lilly (1960) have shown that preparation of the skin with antiseptics may reduce the number of bacteria but not eliminate them completely.It is therefore important to attempt to protect the wound from the entry of organisms from the surrounding skin even though it may have been thoroughly prepared.While we do not deny that wounds may be infected from many sources within and without the theatre, demonstration of the route and source of specific infec- tions is most difficult.All possible sources of organisms should therefore be eradicated or excluded.This paper focuses attention chiefly on one source, one that is often neglected-the patient himself at operation. Summary and ConclusionsNew techniques of skin preparation and skin towelling were introduced into the Surgical Professorial Unit at St. Thomas's Hospital in January, 1959.In the ensuing three years a fall in wound sepsis rate was observed compared with the previous four years.It is stuggested that one of the important sources of organisms infecting surgical wounds may be the patient's own skin.Good exclusion of the skin surface from the wound can be obtained with modem methods.We are grateful to Professor R. Hare and Professor R. A. Shooter for help and suggestions during
Electrotonic influences on action potentials from isolated ventricular cells.
Authors: R C Tan, R W Joyner
Journal: Circulation Research (1990)

This work combines a theoretical study of electrical interactions between two excitable heart cells, using a variable coupling resistance, with experimental studies on isolated rabbit ventricular cells coupled with a variable coupling resistance to a passive resistance and capacitance circuit. The theoretical results show that the response of an isolated cell to an increased frequency of stimulation is strongly altered by the presence of a coupling resistance to another cell. As the coupling resistance gradually is decreased, the stimulated cell becomes able to respond successfully to more rapid stimulation, and then, at levels of coupling resistance that allow conduction between the two cells, the coupled pair of cells exhibits arrhythmic interactions not predicted by the intrinsic properties of either cell. The experimental results show that the isolated rabbit ventricular cell is extremely sensitive to even a very small electrical load, with shortening of the action potential by 50% with electrical coupling to a model cell (of similar input resistance and capacitance to the ventricular cell) as high as 1,000 M omega, even though the action potential amplitude and current threshold are very insensitive to the electrical load.
Comparative Effect of Captopril and Nifedipine in Normotensive Patients With Incipient Diabetic Nephropathy
Authors: Albert Mimran, Alvaro Insua, Jean Ribstein, Jacques Bringer, Louis Monnier
Journal: Diabetes Care (1988)

In these studies, the effect of a 6-wk treatment by placebo, the calcium-channel blocker nifedipine, or the converting-enzyme inhibitor captopril was assessed in normotensive patients with insulin-dependent diabetes and incipient nephropathy. In response to captopril and nifedipine, arterial pressure decreased slightly and to a similar extent. These drugs resulted in opposite effects on urinary excretion of albumin [i.e., increase in urinary albumin excretion (UAE) by 40% during nifedipine treatment and decrease by 40% during captopril treatment]. No change in UAE was observed in the p acebo group. This observation of opposite changes in U E i the presence of a similar fall in arterial pressur suggests that the effects of captopril and nifedipine o UAE result from some difference in their intrarenal a ction. The data do not present recommendations for the use or disuse of captopril or nifedipine in such a group of patients and do not allow extrapolation to hypertensive diabetic subjects well controlled by other conventional antihypertensive agents.
A CONFUSIONAL STATE ASSOCIATED WITH INFECTIVE ENDOCARDITIS
Authors: D. Shaw
Journal: BMJ (1935)

Leucocidin Neutralization Tests.-Mixtures of equal parts of 50 per cent.serum in saline and dilutions of M protein were incubated in a waterbath for thirty minutes at 370 C.At the end of that period cover-slip preparations of leucocytes were exposed for five minutes and then examined as before.The results of these tests, givein in Table III, show that the leucocidin activity of M protein is inhibited by the previous admixture of immune serum, although the neutralizing properties of the latter are not so marked as its precipitating power.Percentage of Leucocytes showing Motility after Exposure to- Dilution of M protein M on'.yM and 50 per cent.M and 50 per cent.Immune Serum Normal Serum lin 12,500 0 0 0 ,, 25,030 0 4 0 ,, 50,
Reviews and Notes: Atlas of Heart Disease. Volume 3: Cardiopulmonary Diseases and Cardiac Tumors
Authors: Bruce F. Waller
Journal: Annals of Internal Medicine (1995)

Literature of Medicine1 October 1995Reviews and Notes: Atlas of Heart Disease. Volume 3: Cardiopulmonary Diseases and Cardiac TumorsBruce F. Waller, MDBruce F. Waller, MDIndiana University School of Medicine, St. Vincent Hospital, Nasser, Smith, and Pinkerton Cardiology, Inc., Indianapolis, IN 46260Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-7-199510010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail SZ Goldhaber; ed. St. Louis: Mosby; 1995. $99.95. ISBN 1-878132-23-7. Order phone 800-426-4545.The Atlas of Heart Disease (Eugene Braunwald, series editor) provides a detailed and comprehensive review of many aspects of cardiovascular medicine. Volume 3 is a pictorial update of the most recent advances in the diagnosis and treatment of cardiopulmonary diseases, including cardiac tumors. Pathophysiologic principles, diagnostic imaging and methods, and treatment are the basis for the presentation in Volume 3. Many echocardiograms, angiograms, and computed tomographic scans are accompanied by illustrations of associated microscopic and gross pathology specimens. The text is divided into four sections: cardiopulmonary diseases, ... Author, Article, and Disclosure InformationAffiliations: Indiana University School of Medicine, St. Vincent Hospital, Nasser, Smith, and Pinkerton Cardiology, Inc., Indianapolis, IN 46260 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1995Volume 123, Issue 7Page: 557KeywordsCardiovascular therapyEmbolectomyHeart diseasesHeart-lung transplantationHospital medicineMetastatic tumorsPulmonary embolismPulmonary hypertensionSub-specialty careThrombosis ePublished: 15 August 2000 Issue Published: 1 October 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Enhancement of myocardial reactive hyperemia with manganese-superoxide dismutase: role of endothelium-derived nitric oxide
Authors: R. Tsunoda, K. Okumura, H. Ishizaka, T. Matsunaga, T. Tabuchi, S. Tayama, H. Yasue
Journal: Cardiovascular Research (1996)

Objective: To test the hypothesis that superoxide radicals generated during myocardial ischemia and reperfusion influence reactive hyperemia (RH) by reacting with endothelium-derived nitric oxide (EDNO), we examined the effect of manganese (Mn)-superoxide dismutase (SOD) on RH in anesthetized dogs. Methods: Twelve dogs were pretreated with 8-phenyltheophylline (8PT) to block adenosine's effect. Five dogs were pretreated with 8PT and NG-nitro-L-arginine methyl ester (L-NAME) to block adenosine's and EDNO's effects. Following occlusion of the left circumflex artery (LCX) for 10 and 60 s, RH was observed before and after Mn-SOD. In another group of 6 dogs pretreated with 8PT, RH following 60-s LCX occlusion was observed before and after Mn-SOD and catalase. For comparison with the effect of Mn-SOD, that of copper, zinc (Cu,Zn)-SOD was also examined in another group of 5 dogs. Results: In the dogs pretreated with 8PT, Mn-SOD significantly increased excess flow and repayment of flow debt during RH after 60-s LCX occlusion but did not affect RH after 10-s LCX occlusion. Mn-SOD-induced augmentation of RH following 60-s LCX occlusion was not affected by catalase, while it was completely abolished by L-NAME. In contrast to Mn-SOD, Cu,Zn-SOD showed no effect on RH following 60-s LCX occlusion in the dogs pretreated with 8PT. Conclusions: Superoxide radicals generated during ischemia for 60 s and reperfusion attenuates myocardial RH through inactivation of EDNO. Mn-SOD shows more beneficial effects on myocardial RH than Cu,Zn-SOD.
Red Cross begins relief effort in Albania
Authors: J. Hamilton
Journal: BMJ (1997)

The International Committee of the Red Cross estimates that thousands of people in Albania are facing shortages of food and medical supplies as a result of the widespread unrest.

It has appealed for Sw fr15m (£6.5m; $10.4m) to cover emergency operations in Albania over the next 90 days. According to Daniel Augstburger, a committee spokesman, as many as 250000 people out of a population of …
A case of lichen planus pemphigoides with autoantibodies to the <scp>NC</scp> 16a and C‐terminal domains of <scp>BP</scp> 180 and to desmoglein‐1
Authors: A. Sekiya, M. Kodera, T. Yamaoka, Y. Iwata, T. Usuda, A. Ohzono, A. Yasukochi, H. Koga, N. Ishii, T. Hashimoto
Journal: British Journal of Dermatology (2014)

Lichen planus pemphigoides (LPP) is a rare autoimmune blistering disease that occurs in association with lichen planus (LP). This report describes a 59-year-old Japanese female patient with LPP. The patient first showed LP lesions on her hands, and subsequently developed bullae on her extremities and erosions of the oral mucosa. The patient's serum was positive for IgG autoantibodies against the BP180 NC16a domain, the BP180 C-terminal domain and desmoglein-1. However, a serum sampled one and a half years before the diagnosis of LPP was negative for autoantibodies against BP180 NC16a and BP180 C-terminal domains. These findings strongly suggest that the damage to the basal cells in the LP lesions exposed a sequestered antigen or formed neoantigens, leading to the production of pathogenic autoantibodies for LPP. Most of the previous cases of LPP have produced autoantibodies to the NC16a domain of BP180. This is the first case in which autoantibodies to the C-terminal domain of BP180 were detected. The oral mucosal symptoms in this case may have been caused by autoantibodies to the BP180 C-terminal domain.
Abstract 4897: A robust 384-well cell migration assay for high content analysis (HCA) of cells treated with anti-cancer therapeutics
Authors: Jennifer A. Fronczak, Keren I. Hulkower, Andreas Vogt
Journal: Cancer Research (2011)

Abstract Platypus Technologies has developed a first-in-class 384-well cell migration assay to enable high throughput screening (HTS) of anti-cancer compounds and wound healing agents on adherent tumor and endothelial cell lines. The assay is completely automatable with liquid handling systems and high content analysis (HCA) instrumentation. This assay format utilizes a centrally located self-dissolving, non-toxic biocompatible gel (BCG) to form a uniformly sized, cell-free detection zone on tissue culture treated or collagen I coated cell culture surfaces. Cells are seeded into 384-well plates and pattern in an annular monolayer surrounding the BCG. Once the BCG dissolves, cells can migrate into the detection zone previously occupied by the BCG. Dose-dependent inhibition of migration was observed using the actin polymerization inhibitors Cytochalasin D and Latrunculin A, the kinase inhibitors Dasatinib and Sorafenib on HT-1080, and human umbilical vein endothelial cells (HUVECs), and the phosphatase inhibitors NSC95397 and BCI on MDA-MB231 human breast cancer cells. While migration of cells was faster on collagen coated surfaces than on tissue culture treated surfaces, the IC 50 values obtained for the compounds and rank order of potency were similar on both surfaces. This assay format allows an unobstructed view of cell motility throughout the duration of the experiment. Cells may be fixed and treated with multiple stains, including Hoechst or DAPI to visualize nuclei and TRITC-phalloidin to observe F-actin, to enable flexible data capture by either enumerating migrating cells or by calculating the area of closure within the detection zone. The 384-well assay was successfully automated using a Biomek 2000 robotic liquid handler and a Cellomics ArrayScan II high content imaging (HCI) instrument. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4897. doi:10.1158/1538-7445.AM2011-4897
Population Genetics of the porB Gene of Neisseria gonorrhoeae: Different Dynamics in Different Homology Groups
Authors: David Posada, Keith A. Crandall, Man Nguyen, James C. Demma, Raphael P. Viscidi
Journal: Molecular Biology and Evolution (2000)

The porB locus codes for the major outer membrane protein of Neisseria gonorrhoeae. Alleles of this locus have been assigned to two homology groups based on close sequence and immunological relationships and are designated as either PIA or PIB. Several population parameters were estimated and compared among these two groups using a data set of 22 PIA sequences and 91 PIB sequences obtained from diverse geographic localities and from time periods spanning approximately 50 years. Recombination appears to be extensive in the porB gene. While the recombination rates are similar for the PIA and PIB sequences, the relative contribution of recombination to genetic diversity is higher for the PIA sequences. Alleles belonging to the PIB group show greater genetic diversity than do those in the PIA group. Although phylogenetic analysis did not reveal temporal or geographic clustering of sequences, estimates of gene flow and the fixation index suggested that PIB sequences exhibit population substructure based on geographic locality. Selection acts in these homology groups in a different way. While positive Darwinian selection is the dominant force driving the evolution of the PIA sequences, purifying selection operates also on the PIB sequences. These differences may be attributable to the greater propensity of PIA strains, as compared with PIB strains, to cause disseminated gonococcal infection, which would expose the former to intense selection pressure from the host immune system. The molecular evolution of Neisseria gonorrhoeae seems to be driven by the simultaneous action of selection and recombination, but under different rates and selection pressures for the PIA and PIB homology groups.
Effects of eight weeks' continuous treatment with oral ranitidine and cimetidine on gastric acid secretion, pepsin secretion, and fasting serum gastrin.
Authors: R Mohammed, R J Holden, J B Hearns, B M McKibben, K D Buchanan, G P Crean
Journal: Gut (1983)

Gastric acid secretion, pepsin secretion, and fasting serum gastrin levels were measured in 23 patients with duodenal ulcer disease, divided into three groups which received either cimetidine 800 mg daily, cimetidine 1600 mg daily, or ranitidine hydrochloride 300 mg daily for eight weeks. Pentagastrin tests were carried out at intervals both before and after treatment. Each dose of cimetidine reduced acid secretion to 42% of control one week after starting therapy. Ranitidine reduced acid secretion to 33% of the pretreatment value. Acid secretion remained suppressed to these levels throughout treatment with each drug. Acid secretion returned to pretreatment levels in all patients one week after treatment and remained normal until the end of the study. Both drugs reduced pepsin, which fell to 64% and 61% (p less than 0.01) after 800 mg and 1600 mg cimetidine respectively and to 65% (p less than 0.005) with ranitidine after one week's treatment. Pepsin secretion remained at this reduced level in both cimetidine groups till the end of treatment. Pepsin levels fell to 50% at two weeks of therapy with ranitidine but stabilised at this level till the end of therapy. Cimetidine withdrawal was followed by a return towards pretreatment levels of pepsin secretion; but secretion remained significantly depressed (p less than 0.05) to the end of the study period. In the ranitidine-treated patients pepsin output returned to normal after drug withdrawal. Fasting gastrin levels rose during treatment with both drugs but failed to reach significant levels. After withdrawal of treatment fasting serum gastrin levels returned to normal in all three groups of patients.
Patterned androgenic alopecia in normal women
Authors: V.A. Venning, R.P.R. Dawber
Journal: British Journal of Dermatology (1987)

Journal Article Patterned androgenic alopecia in normal women Get access V.A. Venning, V.A. Venning Department of Dermatology, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar R.P.R. Dawber R.P.R. Dawber Department of Dermatology, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Page 21, https://doi.org/10.1111/j.1365-2133.1987.tb12005.x Published: 01 June 1987
Critical Appraisal of the Renogram in Renal Vascular Diseas Renogram
Authors: Bruce H. Stewart
Journal: JAMA (1962)

Sixty-four patients with suspected renal hypertension were studied with I<sup>131</sup>sodium o-iodohippurate (Hippuran) renograms, retrograde ureteral catherization studies and arteriograms; occlusive renal vascular disease was found at operation in 20 patients. The renogram was "correct" in 9 of 9 cases with unilateral main artery occlusion, in 4 of 6 cases of bilateral occlusive disease, and in 2 of 5 cases of segmental disease. A quantitative method of interpretation was superior to qualitative evaluation. The radioisotope renogram, by the present technique, was ineffective as a "screening" test of renal hypertension since false-negative results were noted with significant frequency in patients with correctable renal ischemia. It was useful, however, as one of several tests in the evaluation of hypertensive patients and in following patients after revascularization procedures.
We submitted the above letter to Dr. Hawley, who writes:
Authors: George F. Hawley
Journal: JAMA (1906)

public a medicine obtained from America, and they created a demand by flooding the country with advertisements, placards, pamphlets, and imaginary pictures.The eomplainers desired protection for the name "Bile Beans," but being themselves engaged in perpetrating a fraud on the public, they were not entitled to any such protection.An Instance of the "Patent-Medicine" Habit.Dr. J. C. Davis, Rochester, N. Y., reports the following In¬ teresting case of "patent-medicine" addiction: "Mrs.Lottie Shaal died, July 10, from an overdose of 'a nar¬ cotic of some kind.'The coroner waived an autopsy as the woman was addicted to the 'patent-medicine' habit."During the past year she had been taking Cox's Headache Powders, obtained from her grocer.On July 7 she took one box of Cox's Headache Powders; on July 8 a part of a bottle of Hostetter's Bitters, and all of one bottle of Lydia Pinkham's Compound; on the morning of July 9 she went to see a neigh¬ boring physician, who gave her a small powder to quiet her nerves.
Plasma level of cardiotrophin‐1 as a prognostic predictor in patients with chronic heart failure
Authors: Takayoshi Tsutamoto, Shigeru Asai, Toshinari Tanaka, Hiroshi Sakai, Keizo Nishiyama, Masanori Fujii, Takashi Yamamoto, Masato Ohnishi, Atsuyuki Wada, Yoshihiko Saito, Minoru Horie
Journal: European Journal of Heart Failure (2007)