tbuckley/cabot-search huggingface dataset:
Ultrasonography of Leg Veins in Patients Suspected of Having Pulmonary Embolism
Authors: John G. Weg
Journal: Annals of Internal Medicine (1998)

Letters1 February 1998Ultrasonography of Leg Veins in Patients Suspected of Having Pulmonary EmbolismJohn G. Weg, MD and James B. Froehlich, MDJohn G. Weg, MDUniversity of Michigan Medical Center; Ann Arbor, MI 48109Search for more papers by this author and James B. Froehlich, MDUniversity of Michigan Medical Center; Ann Arbor, MI 48109Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-3-199802010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Turkstra and colleagues espouse an untenable position: that a positive result on ultrasonography for deep venous thrombosis of the thigh is false if pulmonary embolism is not documented and that asymptomatic deep venous thrombosis therefore need not be treated in the absence of pulmonary embolism. Untreated symptomatic deep venous thrombosis has a historical mortality rate of 12% to 37% [1]; in asymptomatic, high-risk patients, the mortality rate is 1% to 5% [2]. Although the handful of patients not treated in this study did not develop pulmonary embolism or die, the standard of care mandates anti-coagulation for deep ...References1. Byrne JJ. Phlebitis: a study of 748 cases at the Boston City Hospital. N Engl J Med. 1955; 253:579-86. Google Scholar2. Clagett GP, Anderson FA, Heit J, Levine MN, Wheeler HB. Prevention of venous thromboembolism. Chest. 1995; 108:312S-34S. Google Scholar3. Hyers TM, Hull RD, Weg JG. Antithrombotic therapy for venous thromboembolic discase. Chest. 1995; 108:335S-51S. Google Scholar4. Lensing AW, Doris CI, McGrath FP, Cogo A, Sabine MJ, Ginsberg J, et al. A comparison of compression ultrasound with color Doppler ultrasound for the diagnosis of symptomless postoperative deep vein thrombosis. Arch Intern Med. 1997; 157:765-8. Google Scholar5. Husiman MV, Buller HR, ten Cate JW, van Royen EA, Vreeken J, Kersten MJ, et al. Unexpected high prevalence of silent pulmonary embolism in patients with deep venous thrombosis. Chest. 1989; 95:498-502. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Michigan Medical Center; Ann Arbor, MI 48109 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMortality of Untreated Deep Vein Thrombosis Following Knee Arthroscopy 1 February 1998Volume 128, Issue 3Page: 243KeywordsDeath ratesDeep vein thrombosisKneesPulmonary embolismPulmonary medicineSigns and symptomsSpecificityUltrasound imagingVeinsVenous thromboembolism Issue Published: 1 February 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
1058 INSULIN RESISTANCE: A MAJOR PREDICTOR OF SIGNIFICANT LIVER FIBROSIS IN EGYPTIAN PATIENTS WITH GENOTYPE 4 CHRONIC HEPATITIS C
Authors: A. El Ray, R. Moucari, M. El Ghannam, A.A. Taha, M.A. Saber, M. Akl, T. Asselah, R. Atta, M. Shemis, A.S. Radwan, A. Ghali, V. Paradis, P. Marcellin
Journal: Journal of Hepatology (2010)
Minor Motor Epilepsy
Authors: Lydia Pauli, Richard O'Neil, Manuel Ybanez, Samuel Livingston
Journal: JAMA (1960)

The most serious hazard of minor motor epilepsy is the associated mental and motor retardation, or both, which is found, in some degree, in essentially all patients. The use of corticotropin or steroids has been recommended in recent publications. The present study comprises 14 children with minor motor epilepsy, mental retardation, and hypsarhythmic electroencephalographic abnormalities. Corticotropin was given alone in eight cases; corticotropin was followed by triamcinolone in one; cortisoneacetate was given in two cases; prednisone was given in two cases, and triamcinolone was given alone in one case. In four cases there was improvement with respect to seizures, but in no case was there significant improvement in mental status.
Abstract 5361: Development of targeted inhibitors against RecQ1 helicase
Authors: Mingxin Zuo, David Maxwell, Basvoju A. Bhanu Prasad, Zhenghong Peng, William Bornmann, Milind M. Javle
Journal: Cancer Research (2014)

Abstract Background: RecQ helicases are a ubiquitous family of DNA unwinding enzymes involved in the maintenance of chromosome stability. RecQ1 helicase genomic variations have an important prognostic role and represents a therapeutic target in pancreatic cancer [JCO 2006; 24 (11) 1720-1728]. Pubchem data indicated potential RecQ1 activity &amp;gt;600 compounds using a qHTS RecQ1 assay (NIH Chemical Genomics Center). Methods: We applied a set of filters including molecular weight, potency and Hill curve fitting and also removed those interfering with biological assay to identify sixteen compounds for studying RecQ1 inhibition. Two compounds showed strong inhibition of RecQ1 helicase activity at 50 µM and at IC50 &amp;lt; 5 µM, respectively. From a large library of compounds, eight potential inhibitors were synthesized in three simple steps. First, sulfonylation of various amines with 3-Nitrobenzenesulfonyl chloride was performed followed by reduction of the nitro group into an amine. Finally, acylation with variety of acid chlorides resulted in the final library of RecQ1 analogs. These agents were studied for RecQ1 helicase activity assay with the radiolabeled partial duplex substrate in vitro. The RecQ1 inhibitor candidate compounds were investigated in pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, PANC-1, and Mia-Paca2) for anti-tumor efficacy using cell proliferation assay with CellTiter-Glo® luminescence. Combination studies with test compounds and poly (ADP ribose) polymerase (PARP) inhibitor olaparib and topoisomerase Inhibitor SN38 were performed. Results: Though none of the compounds showed the same level of activity of the parent compounds, we were able to demonstrate a modest level of helicase activity with several. Two compounds displayed strong inhibition of pancreatic cancer cell proliferation. Two other compounds displayed synergistic inhibition with SN38 or olaparib of pancreatic cancer cell proliferation and induced DNA damage. Conclusions: Synthesis of RecQ1 inhibitors is feasible and shows potential for anti-tumor efficacy. Note: This abstract was not presented at the meeting. Citation Format: Mingxin Zuo, David Maxwell, Basvoju A. Bhanu Prasad, Zhenghong Peng, William Bornmann, Milind M. Javle. Development of targeted inhibitors against RecQ1 helicase. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5361. doi:10.1158/1538-7445.AM2014-5361
Does Low Total Creatine Kinase Rule Out Myocardial Infarction?
Authors: Laura Bilodeau, Lynne M. Preese, Fred S. Apple
Journal: Annals of Internal Medicine (1992)

Letters15 March 1992Does Low Total Creatine Kinase Rule Out Myocardial Infarction?Laura Bilodeau, MD, Lynne M. Preese, MBA, Fred S. Apple, PhDLaura Bilodeau, MDSearch for more papers by this author, Lynne M. Preese, MBASearch for more papers by this author, Fred S. Apple, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-6-523_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Serial creatine kinase and creatine kinase-MB measurements with clinical history findings, physical examination findings, and electrocardiographic (ECG) changes are the standards for diagnosing acute myocardial infarction (1, 2). Whether creatine kinase-MB measurements should be quantified when total creatine kinase activity never rises above the upper limit of the normal range is unclear (3, 4). We wondered whether there truly was an upper limit of the normal range for creatine kinase-MB measurements and whether percent relative index (creatine kinase-MB mass concentration/ total creatine kinase activity) might misdiagnose acute myocardial infarction when the total creatine kinase activity is normal....References1. Lee T and Goldman L. Serum enzyme assays in the diagnosis of acute myocardial infarction: recommendations based on a quantitative analysis. Ann Intern Med. 1986;105:221-33. LinkGoogle Scholar2. Apple F. Cardiovascular disorders. Clin Chem. 1991;63:165R-171R. Google Scholar3. Dillon M, Calbreath D, and Dixon A. Diagnostic problem in acute myocardial infarction. Arch Intern Med. 1982;142:33-8. CrossrefMedlineGoogle Scholar4. D'Souza J, Sine H, and Horritz R. The significance of the MB isoenzyme in patients with acute cardiovascular disease with a normal or borderline total CPK activity. Clin Biochem. 1978;11:204-9. CrossrefMedlineGoogle Scholar5. Apple F, Preese L, and Riley L. Financial impact of a rapid CK-MB-specific immunoassay on the diagnosis of myocardial infarction. Arch Path Lab Med. 1990;114:1017-20. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Laura Bilodeau, MD; Lynne M. Preese, MBA; Fred S. Apple, PhDAffiliations: Hennepin County Medical Center Minneapolis, MN 55415 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCarcinosarcoma of the ovary: Natural history, patterns of treatment, and outcomeCardiac FunctionBiochemical markers of myocardial damage 15 March 1992Volume 116, Issue 6 Page: 523-524 Keywords Acute myocardial infarction Creatine Creatine kinase Electrocardiography Myocardial infarction ePublished: 1 December 2008 Issue Published: 15 March 1992 PDF downloadLoading ...
Geriatric Care in the United Kingdom: An American Perspective
Authors: ANNE R. SOMERS
Journal: Annals of Internal Medicine (1976)

Geriatric care is a complex and challenging aspect of health care. The United Kingdom, with 13.6% of its population over 65 years of age, compared to 10.1% in the United States, has given special attention to this field. Characteristics of the British system include financing through the National Health Service, existence of a specialty of geriatrics, absence of "nursing homes," emphasis on home care, and avoidance of "heroics" for the terminally ill. While British life expectancy at birth is longer than that for Americans, the opposite is now true for those over 65. The British have made efforts to maximize efficiency in a high-demand, comparatively low-resource context. But there are limits to which professional dedication and patient manipulation can be pushed. Some new policy directions—primarily aimed at prevention and other methods of reducing demand, other than reimposing financial barriers—may have to be explored.
Treatment of Spinal Cord Injury
Authors: Ralph Cloward
Journal: JAMA (1974)

<h3>To the Editor.—</h3> I expected my letter (226:1008, 1973) to provoke criticism from those who continue to employ and recommend older treatment methods for cervical spine injuries. My "whirlwind epistle," as Dr. White called it (227:1006, 1974), was not meant to be a statistical review of physiological experiments on spinal cord trauma, but a mere outline of a treatment program and an explanation why the results have been superior to those obtained by methods that I used previously. My statement that "paralysis can be cured and more patients will walk" is factual, as I have seen more patients with minimal to moderate damage recover the use of their paralyzed limbs following treatment by early operation (anterior decompression and interbody fusion) than with skull traction or laminectomy. Others have reported similar experience.<sup>1-4</sup>This is attributed in part to (1) early surgical removal of intraspinal ruptured disk masses causing spinal cord
Polio Vaccine Schedule Will Change, but When?
Authors: Charles Marwick
Journal: JAMA (1996)

A NOTE of measured caution has been sounded as plans to recommend a shift from the current oral poliovirus vaccine (OPV) to the inactivated poliovirus vaccine (IPV) in the childhood immunization schedule move toward completion. The alert appears to have been triggered by the efforts of groups opposed to the change. Four hours are to be scheduled for public comments on the proposal during the June meeting of the Advisory Committee on Immunization Practices (ACIP), which advises the director of the Centers for Disease Control and Prevention (CDC) on vaccine policy recommendations. At its February meeting, the ACIP considered a revised draft of the polio vaccination statement. In addition to laying down what it termed a "preferred schedule" that covers the change to IPV for the first two doses, it also provides an "alternative schedule" that, in principle, continues the current OPV schedule. Pending changes in details, the committee has
Effects of Steroid Hormones on Human Polymorphonuclear Leukocyte Lysosomes
Authors: Robert H. Persellin, Leighton C. Ku
Journal: Journal of Clinical Investigation (1974)

Lysosomal membrane stabilization has been proposed as a mechanism for the anti-inflammatory action of corticosteroid hormones. This hypothesis was based on studies with liver organelles. We studied the action of steroids on intact lysosomes isolated from human peripheral blood polymorphonuclear (PMN) leukocytes. Both androstenedione and progesterone, 10(-3)-10(-5) M, caused leakage of acid hydrolase markers from these organelles, thus resembling their effects on liver lysosomes. But none of the anti-inflammatory steroids tested protected organelle membranes from either detergent lysis (Triton X-100) or heat incubation (37 degrees C, 90 min). Hydrocortisone (HC), HC sodium succinate, HC acetate, HC hemisuccinate, prednisone, and dexamethasone were without detectable stabilizing activity at concentrations of 10(-3)-5 x 10(-8) M. Release of the lysosomal marker, beta-glucuronidase, was not retarded by any of the compounds studied. In addition, PMN leukocyte lysosomes isolated from human volunteers receiving prednisolone were not more stable than control organelles, nor did serum from steroid-treated humans protect intact lysosomes from detergent lysis. Variations in cholesterol and phospholipid contents of liver and PMN leukocyte lysosome membranes could possibly account for the different reactivity to corticosteroids observed. We believe that the anti-inflammatory activity of adrenal corticosteroids can best be explained by their inhibitory effects on cellular metabolism rather than by their direct interaction with lysosomal membranes.
Computerisation of primary care in Wales.
Authors: P J Rogers, G Fletcher
Journal: BMJ (1991)

sawtooth pattern might be expected, with low diagnostic accuracy in February and March and in August and September, rising (with a little "noise" from locum cover) towards a peak when doctors were trained.No training effect is seen-at least, none that is clinically useful.It is not credible that the package used in Bangour resulted in junior doctors being trained within the first month of their contract, though that is possible for Mr de Dombal and colleagues' system.One explanation of these results is that where a computer system stimulates consultants' interest in junior doctors' training a useful gain is seen, but where the computer system comes to be a subsitute for that the learning curve remains flat.
Allergic reactions associated with airborne fish particles in IgE‐mediated fish hypersensitive patients
Authors: J. F. Crespo, C. Pascual, C. Dominguez, I. Ojeda, F. M. Muñoz, M. M. Esteban
Journal: Allergy (1995)

We evaluated the clinical characteristics found in 21 children who showed allergic reactions upon incidental inhalation offish odors or fumes, from 197 diagnosed with IgE‐mediated fish hypersensitivity. Allergic reactions to fish via ingestion began in most patients (86%) within the first 24 months of life. The vast majority (19/21) of patients showed cutaneous symptoms, either alone or, less frequently, associated with other clinical manifestations. Hake and flounder were the species offish most frequently implicated in eliciting clinical manifestations upon ingestion. After diagnosis, all these patients were placed on a strict fish‐avoidance diet. During this period of avoidance, patients reported allergic reactions (mean age 7 years) after incidental exposure to airborne fish odors or fumes. Clinical manifestations through inhalation were respiratory (mainly wheezing) in 12 patients and cutaneous (mainly urticaria) in nine patients. Nineteen of 21 patients reported three or more episodes upon exposure to fish aerosols; in most cases, these episodes occurred at home when other people were eating fish. In conclusion, incidental inhalation of fish odors or fumes could play an important role in accidental and unknown encounters with fish in children on fish‐avoidance diets for fish IgE‐mediated hypersensitivity. Such exposures could elicit clinical symptoms and could have some effect in delaying the development of tolerance.
Cloning of chromosomal DNA from Haemophilus influenzae. Its use for studying the expression of type b capsule and virulence.
Authors: E R Moxon, R A Deich, C Connelly
Journal: Journal of Clinical Investigation (1984)

Haemophilus influenzae may make any one of six chemically distinct capsular polysaccharides, but only strains of capsular serotype b commonly cause systemic infection (e.g., meningitis) in humans. Molecular cloning of DNA was used to investigate the expression of type b capsule and its association with H. influenzae virulence. A virulent H. influenzae type b strain was used to construct a lambda library of chromosomal DNA in Charon 4. Two independently isolated recombinant phage were isolated from the library and were found to possess DNA necessary for expression of type b capsule. Using a well-characterized rat model of H. influenzae systemic infection, we showed that type b transformants elicited by the cloned DNA were pathogenic, causing bacteremia and meningitis, whereas the untransformed capsule-deficient H. influenzae organisms were not. A 4.4-kb EcoRI fragment, common to both DNA clones, was used to characterize clinical isolates representing all six encapsulated serotypes as well as several capsule-deficient H. influenzae by Southern hybridization analysis. The probe hybridized to an identical sized (4.4 kb) fragment of EcoRI-digested chromosomal DNA from eight independently isolated type b strains. Single bands of homology to the probe were also found in EcoRI fragments of chromosomal DNA obtained from 33 encapsulated, nontype b H. influenzae. However, the size of these EcoRI fragments proved to be characteristic for each of the different capsular serotypes. These studies provide a basis for pursuing the molecular analysis of the epidemiology and virulence of pathogenic H. influenzae.
Emergency Department Physician Activation of the Catheterization Laboratory and Immediate Transfer to an Immediately Available Catheterization Laboratory Reduce Door-to-Balloon Time in ST-Elevation Myocardial Infarction
Authors: Umesh N. Khot, Michele L. Johnson, Curtis Ramsey, Monica B. Khot, Randall Todd, Saeed R. Shaikh, William J. Berg
Journal: Circulation (2007)

Consensus guidelines and hospital quality-of-care programs recommend that ST-elevation myocardial infarction patients achieve a door-to-balloon time of < or = 90 minutes. However, there are limited prospective data on specific measures to significantly reduce door-to-balloon time.We prospectively determined the impact on median door-to-balloon time of a protocol mandating (1) emergency department physician activation of the catheterization laboratory and (2) immediate transfer of the patient to an immediately available catheterization laboratory by an in-house transfer team consisting of an emergency department nurse, a critical care unit nurse, and a chest pain unit nurse. We collected door-to-balloon time for 60 consecutive ST-elevation myocardial infarction patients undergoing emergency percutaneous intervention within 24 hours of presentation from October 1, 2004, through August 31, 2005, and compared this group with 86 consecutive ST-elevation myocardial infarction patients from September 1, 2005, through June 26, 2006, after protocol implementation. Median door-to-balloon time decreased overall (113.5 versus 75.5 minutes; P<0.0001), during regular hours (83.5 versus 64.5 minutes; P=0.005), during off-hours (123.5 versus 77.5 minutes; P<0.0001), and with transfer from an outside affiliated emergency department (147 versus 85 minutes; P=0.0006). Treatment within 90 minutes increased from 28% to 71% (P<0.0001). Mean infarct size decreased (peak creatinine kinase, 2623+/-3329 versus 1517+/-1556 IU/L; P=0.0089), as did hospital length of stay (5+/-7 versus 3+/-2 days; P=0.0097) and total hospital costs per admission ($26,826+/-29,497 versus $18,280+/-8943; P=0.0125).Emergency department physician activation of the catheterization laboratory and immediate transfer of the patient to an immediately available catheterization laboratory reduce door-to-balloon time, leading to a reduction in myocardial infarct size, hospital length of stay, and total hospital costs.
Asymptomatic Parotid Enlargement: Probable Diabetic Origin
Authors: David E. Silverman
Journal: JAMA (1975)

To the Editor.—  The appearance of asymptomatic, bilateral parotid enlargement is widely recognized as a relatively frequent clinical occurrence. It has been noted in Mikulicz syndrome associated with sarcoidosis, in Reiter syndrome, and in several other disorders. However, it is not generally appreciated that this interesting physical finding can also be associated with diabetes mellitus.  Report of a Case.—  A 50-year-old woman's condition was first diagnosed as adult-onset diabetes mellitus at age 46. After evaluation at another hospital, she was placed on an American Diabetes Association diet and a daily dose of approximately 100 mg of tolbutamide. During the succeeding four years, the patient demonstrated poor diabetic control on numerous occasions and was eventually switched to tolazamide, 500 mg daily.  On the day of admission to our hospital, the patient was complaining of dizziness, weakness, and faintness. She gave a history of diabetes, and a blood glucose level determined at
Detection of residual jeopardized myocardium 3 weeks after myocardial infarction by exercise testing with thallium-201 myocardial scintigraphy.
Authors: J D Turner, K M Schwartz, J R Logic, L T Sheffield, S Kansal, D I Roitman, J A Mantle, R O Russell, C E Rackley, W J Rogers
Journal: Circulation (1980)