tbuckley/cabot-search huggingface dataset:
Quality Improvement Noted
Authors: Mike Mitka
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Non-Hodgkin's lymphoma presenting as multiple bone lesions and hypercalcemia
Authors: Hirotaka Takasaki, Heiwa Kanamori, Maki Takabayashi, Satoshi Yamaji, Hideyuki Koharazawa, Jun Taguchi, Katsumichi Fujimaki, Yoshiaki Ishigatsubo
Journal: American Journal of Hematology (2006)

We report a rare case of a patient with non-Hodgkin's lymphoma who developed multiple bone lesions and hypercalcemia. A 50-year-old woman complained of drowsiness and multiple bone pain on admission. Radiographic examination revealed multiple bone fractures and osteolytic lesions. She was diagnosed with diffuse large B cell lymphoma by biopsy of an inguinal lymph node. Elevation of parathyroid hormone-related protein (PTHrP) and hypercalcemia were confirmed pretreatment, and those serum levels decreased during chemotherapy for lymphoma. However, the disease was resistant to chemotherapy combined with rituximab. These findings suggest that hypercalcemia is associated with PTHrP and the prognosis of patients with bone lymphoma in advanced stage is poor, although it is thought to be a relatively favorable prognosis in localized primary lymphoma of bone. Am. J. Hematol. 81:439–442, 2006. © 2006 Wiley-Liss, Inc.
Increased SR Ca cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats
Authors: L MAIER, C WAHLSCHOTT, W HORN, S WEICHERT, C PAGEL, S WAGNER, N DYBKOVA, O MULLER, M NABAUER, W FRANZ
Journal: Cardiovascular Research (2005)

Objective: Heart failure is associated with reduced function of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) but increased function of sarcolemmal Na+/Ca2+ exchanger (NCX), leading to decreased SR Ca2+ content and loss of frequency-potentiation of contractile force. We reported that SERCA2a-overexpression in transgenic rat hearts (TG) results in improved contractility. However, it was not clear whether TG have improved contractility due to frequency-dependent improved SR Ca2+ handling.
The duke multicenter coronary transluminal extraction-endarterectomy registry: Acute and chronic results
Authors: Michael H. Sketch, William W. O'Neill, Joseph P. Galichia, Robert C. Feldman, Craig M. Walker, Steven R. Sawchak, James E. Tcheng, Thomas C. Wall, Harry R. Phillips, Richard S. Stack
Journal: Journal of the American College of Cardiology (1991)
Deconstructing Debriefing for Simulation-Based Education
Authors: Dana P. Edelson, Cynthia M. LaFond
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Conservative Management of Cutaneous Capillary Hemangioma
Authors: John T. Phelan
Journal: JAMA (1963)

Fifty-five children with 83 cutaneous capillary hemangiomas who received no treatment were followed up for periods ranging from 3 to 9 years. Of the 83 lesions, 54 regressed completely; and 24 lesions were still undergoing active regression. Five lesions failed to regress, but remained stationary in size and caused the patients little discomfort. These findings indicate the wisdom of conservative management of the majority of cutaneous capillary hemangiomas in infants and children.
Translocation t(2;3)(p15–23;q26–27) in myeloid malignancies: report of 21 new cases, clinical, cytogenetic and molecular genetic features
Authors: M Stevens-Kroef, B Poppe, S van Zelderen-Bhola, E van den Berg, M van der Blij-Philipsen, A Geurts van Kessel, R Slater, G Hamers, L Michaux, F Speleman, A Hagemeijer
Journal: Leukemia (2004)
80 SAFETY AND TOLERABILITY OF HUMAN MESENCHYMAL STEM CELLS FOR PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS: A PRELIMINARY STUDY
Authors: Q. Fu, S. Jiang, X. Wang, Z. Luo, L. Ni, S. Ye, F. Zhou, L. Shi, J. Chen, G. Lv, Z. Wang, C. Chen, X. Hu
Journal: Journal of Hepatology (2013)
Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway
Authors: Maolan Li, Zhou Zhang, Xiaoguang Li, Junyi Ye, Xiangsong Wu, Zhujun Tan, Chang Liu, Baiyong Shen, Xu-An Wang, Wenguang Wu, Daizhan Zhou, Di Zhang, Ting Wang, Bingya Liu, Kai Qu, Qichen Ding, Hao Weng, Qian Ding, Jiasheng Mu, Yijun Shu, Runfa Bao, Yang Cao, Peizhan Chen, Tianyu Liu, Lin Jiang, Yunping Hu, Ping Dong, Jun Gu, Wei Lu, Weibin Shi, Jianhua Lu, Wei Gong, Zhaohui Tang, Yong Zhang, Xuefeng Wang, Y Eugene Chin, Xiaoling Weng, Hong Zhang, Wei Tang, Yonglan Zheng, Lin He, Hui Wang, Yun Liu, Yingbin Liu
Journal: Nature Genetics (2014)
ROENTGENOGRAPHIC SIGNS OF POSTTRAUMATIC FAT EMBOLISM
Authors: H. B. Greenberg
Journal: JAMA (1968)

Recognizing the syndrome of posttraumatic fat embolism can be difficult. The onset of tachypnea, pulmonary rales, cyanosis, and stupor is frequently so rapid and dramatic that all efforts must be directed toward resuscitation. In such instances, the physician's use of pressure-or volume-cycled respirators to assist or control the patient's ventilation can be lifesaving.  But among war casualties and accident victims, the signs of pulmonary injury from fat embolism may resemble those from thoracic trauma or heart failure. And, in older patients, thromboembolism must also be considered. Moreover, the cerebral injury from fat embolism may be confused with epidural hematoma or cerebral contusion. Tests for fat globules in the urine or elevated serum lipase activity are time consuming and occasionally misleading. The appearance of the patient's chest roentgenogram, however, often provides a clue to rapid diagnosis.  A widespread loss of pulmonary radiolucency, obliteration of the vascular markings, and diffuse parenchymal infiltrates
Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist.
Authors: W P Arend, H G Welgus, R C Thompson, S P Eisenberg
Journal: Journal of Clinical Investigation (1990)

Human monocytes cultured on adherent IgG produce a specific IL-1 inhibitor that functions as a receptor antagonist (IL-1ra). This molecular has been purified, sequenced, cloned as a cDNA, and expressed in Escherichia coli. Recombinant IL-1ra has 17,000 mol wt and binds to IL-1 receptors on T lymphocytes, synovial cells, and chondrocytes with an affinity nearly equal to that of IL-1. These studies have examined some biological properties of purified recombinant human IL-1ra. This protein exhibits a dose-responsive inhibition of Il-1 alpha and Il-1 beta augmentation of PHA-induced murine thymocyte proliferation. The recombinant IL-1ra also blocks IL-1 alpha and IL-1 beta stimulation of PGE2 production in human synovial cells and rabbit articular chondrocytes, and of collagenase production by the synovial cells. A 50% inhibition of these IL-1-induced biological responses requires amounts of IL-1ra up to 100-fold in excess of the amounts of IL-1 alpha or IL-1 beta present. IL-1ra may play an important role in normal physiology or in pathophysiological states by functioning as a natural IL-1 receptor antagonist in the cell microenvironment.
Introduction to the special issue on potassium channels
Authors: L H Opie, E Carmeliet
Journal: Cardiovascular Research (1992)

Journal Article Introduction to the special issue on potassium channels Get access L H Opie, L H Opie Search for other works by this author on: Oxford Academic PubMed Google Scholar E Carmeliet E Carmeliet Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 11, November 1992, Page 1010, https://doi.org/10.1093/cvr/26.11.1010 Published: 01 November 1992
Screening for Germline Mismatch Repair Mutations Following Diagnosis of Sebaceous Neoplasm
Authors: Jessica N. Everett, Victoria M. Raymond, Monica Dandapani, Monica Marvin, Wendy Kohlmann, Anu Chittenden, Erika Koeppe, Shanna L. Gustafson, Tobias Else, Douglas R. Fullen, Timothy M. Johnson, Sapna Syngal, Stephen B. Gruber, Elena M. Stoffel
Journal: JAMA Dermatology (2014)

IMPORTANCE Sebaceous neoplasms (SNs) define the Muir-Torre syndrome variant of Lynch syndrome (LS), which is associated with increased risk for colon and other cancers necessitating earlier and more frequent screening to reduce morbidity and mortality.Immunohistochemical (IHC) staining for mismatch repair (MMR) proteins in SNs can be used to screen for LS, but data on subsequent germline genetic testing to confirm LS diagnosis are limited.OBJECTIVE To characterize the utility of IHC screening of SNs in identification of germline MMR mutations confirming LS.DESIGN, SETTING, AND PARTICIPANTS Retrospective study at 2 academic cancer centers of 86 adult patients referred for clinical genetics evaluation after diagnosis of SN.MAIN OUTCOMES AND MEASURES Results of tumor IHC testing and germline genetic testing were reviewed to determine positive predictive value and sensitivity of IHC testing in diagnosis of LS. Clinical variables, including age at diagnosis of SN, clinical diagnostic criteria for LS and Muir-Torre syndrome, and family history characteristics were compared between mutation carriers and noncarriers.RESULTS Of 86 patients with SNs, 25 (29%) had germline MMR mutations confirming LS.Among 77 patients with IHC testing on SNs, 38 (49%) had loss of staining of 1 or more MMR proteins and 14 had germline MMR mutations. Immunohistochemical analysis correctly identified 13 of 16 MMR mutation carriers, corresponding to 81% sensitivity. Ten of 12 patients(83%) with more than 1 SN had MMR mutations. Fifty-two percent of MMR mutation carriers did not meet clinical diagnostic criteria for LS, and 11 of 25 (44%) did not meet the clinical definition of Muir-Torre syndrome. CONCLUSIONS AND RELEVANCE Immunohistochemical screening of SNs is effective in identifying patients with germline MMR mutations and can be used as a first-line test when LSis suspected. Abnormal IHC results, including absence of MSH2, are not diagnostic of LS and should be interpreted cautiously in conjunction with family history and germline genetic testing. Use of family history to select patients for IHC screening has substantial limitations,suggesting that universal IHC screening of SNs merits further study. Clinical genetics evaluation is warranted for patients with abnormal IHC test results, normal IHC test results with personal or family history of other LS-associated neoplasms, and/or multiple SNs.
Dual Inheritance of Sudden Death from Cardiovascular Causes
Authors: Britt M. Beckmann, Arthur A.M. Wilde, Stefan Kääb
Journal: New England Journal of Medicine (2008)

The long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia are the most common inherited cardiac channelopathies. These authors identified the coexistence of the two diseases in one family. During the past 30 years, nine members have died suddenly between 7 and 40 years of age.
Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53
Authors: Perry Stambolsky, Yuval Tabach, Giulia Fontemaggi, Lilach Weisz, Revital Maor-Aloni, Zahava Sigfried, Idit Shiff, Ira Kogan, Moshe Shay, Eyal Kalo, Giovanni Blandino, Itamar Simon, Moshe Oren, Varda Rotter
Journal: Cancer Cell (2010)
CELLULAR DYNAMICS IN THE INTESTINAL MUCOSA: THE EFFECT OF IRRADIATION ON EPITHELIAL MATURATION AND MIGRATION
Authors: Nathan B. Friedman
Journal: The Journal of Experimental Medicine (1945)

Although irradiation of the duodenum of rats inhibits mitosis in the crypts and halts the normal passage of cells up the villi, the maturation of goblet cells is not affected. The ripening of mucous elements while arrested in the crypts, where they form, instead of during their migration along the villi, results in the so called mucous change, which has hitherto been considered a form of degeneration. During the phase of recovery, the reestablishment of normal migration and desquamation is marked by the appearance of strata of fully formed goblet cells at successive levels out along the villi. It is suggested that some gastrointestinal disturbances known to occur in spontaneous and experimental vitamin deficiency might be explained in terms of aberrations in the cellular replacement of the intestinal mucosa.
STUDIES ON THE TRANSFER OF LYMPH NODE CELLS
Authors: Susanna Harris, T. N. Harris, Clifton A. Ogburn, Miriam B. Farber
Journal: The Journal of Experimental Medicine (1956)

Shigella paradysenteriae organisms were incubated in a solution of trypsin and then removed from the suspension by Seitz filtration. Serologic tests with anti whole Shigella serum indicated that the filtrate contained antigenic material derived from the organisms. When lymph node cells from rabbits not previously injected with Shigella were incubated in vitro with such filtrates and then transferred to irradiated recipients, agglutinins to Shigella appeared in the sera of the latter. The transfer of heated suspensions of cells was not followed by the appearance of agglutinins in irradiated recipient rabbits. Non-irradiated recipients of lymph node cells incubated with the filtrate also developed agglutinin titers, to a lower level than irradiated animals. Agglutinins did not appear in the sera of the majority of non-irradiated recipients of heated cells. The addition of excess antiserum to either the filtrate or the cell suspension before the incubation of these two materials resulted in a marked reduction in the subsequent agglutinin titers of recipient animals. However, if antiserum was added at the conclusion of the usual 30 minute incubation of cells and filtrate, or even after 5 minutes of incubation, there was no reduction in the agglutinin titers of the recipients. Cytologic examination of aliquots of a number of the suspensions of cells prepared for transfer revealed that approximately 98 to 99 per cent of the cells belonged to the lymphocytic series.
Separation of pluripotent stem cells and early B lymphocyte precursors with antibody Fall-3.
Authors: C E Müller-Sieburg
Journal: The Journal of Experimental Medicine (1991)

A major goal in the study of hematopoiesis is to obtain populations of primitive stem cells, free of restricted and mature cells. We previously showed that a small population of normal bone marrow, the Thy-1loLin- cells, was highly enriched for pluripotent stem cells that repopulate lethally irradiated mice. These cells also differentiated along the B lymphocyte lineage in response to the stromal elements in Whitlock-Witte cultures. These two hematopoietic activities were entirely contained in and were enriched to similar extents in the Thy-1loLin- population. Here we show for the first time that these two activities can be resolved functionally and phenotypically. The cells that respond to the stroma in lymphoid culture are more sensitive to the cytotoxic drug 5-Fluorouracil than are stem cells. Furthermore, we have derived a new monoclonal antibody, Fall-3, that detects primitive stem cells but does not label the B cell precursor. This indicates that the small Thy-1loLin- population is heterogeneous, containing precursors restricted to the B cell lineage as well as pluripotent stem cells. Antibody Fall-3 defines a novel stem cell antigen, expressed on all primitive stem cells and thus, will be useful in the further characterization and isolation of both stem cells and B cell precursors.
Unusual presentation of pseudomonas infection.
Authors: S. N. Jowitt, J. A. Yin, P. R. Johnson, A. Tooth
Journal: BMJ (1988)

adults with upper airway obstruction have been emphasised elsewhere.2It is also surprising that both patients seemed to have most difficulty on expiration.Narrowing of the supraglottic air space usually leads to restricted inspiration and eventually inspiratory stridor.
THYROTOXICOSIS CONTINUING AFTER EXTREME OPERATIVE, IODINE AND ROENTGEN THERAPY
Authors: D. B. Phemister
Journal: JAMA (1933)

This case of thyrotoxicosis is reported because of the extreme extent to which the thyroid gland was removed at operation and its remaining portions subsequently destroyed by pole ligations and roentgen treatment. Despite these measures and extensive iodine administration, severe thyrotoxicosis continued, and a complicating infection led to a fatal termination. At autopsy the neck was searched and no thyroid tissue was found. <h3>History.</h3> —A woman, aged 41, seen by Dr. D. P. Abbott, Feb. 27, 1925, because of symptoms of nervousness, weakness, palpitation of the heart, and loss of weight, had been struck, six months previously, in the frontal region by a bolt, producing a depressed fracture of the walls of the frontal sinuses. One month later, an operation was done for the purpose of elevating the depressed bone. Soon after that she began to tire easily and to lose weight, having lost 15 pounds (6.8 Kg.) since the
Anabolic steroids in athletics.
Authors: D Freed, A J Banks, D Longson
Journal: BMJ (1972)

<h3>Background</h3> Morbidity and mortality remain high following infant cardiac arrest. Optimal cardiopulmonary resuscitation (CPR) is therefore imperative. <h3>Objective</h3> Comparison of two-thumb (TT) and two-finger (TF) infant chest compression technique compliance with international recommendations. <h3>Design</h3> Randomised cross-over experimental study. <h3>Methods</h3> Twenty-two certified Advanced Paediatric Life Support (APLS) instructors performed 2 min continuous TT and TF chest compressions on an instrumented infant CPR manikin. Compression depth (CD), release force (RF), compression rate (CR) and duty cycles (DCs) were recorded. Quality indices were developed to calculate the proportion of compressions that complied with internationally recommended targets, and an overall quality index was used to calculate the proportion that complied with all four targets. <h3>Results</h3> Mean CD was 33 mm and 26 mm (p&lt;0.001; target ≥36.7 mm), mean RF was 0.8 kg and 0.2 kg (p&lt;0.001; target &lt;2.5 kg), mean CR was 128/min and 131/min (p=0.052; target 100–120/min) and mean DCs was 61% and 53% (p&lt;0.001; target 30–50%) for the TT and TF techniques, respectively. With the exception of RF, the majority of compressions failed to comply with targets. The TT technique improved median CD compliance (6% vs 0% (p&lt;0.001)), while the TF technique improved median DC compliance (23% vs 0% (p&lt;0.001)). Overall compliance with all four targets was &lt;1% for both techniques (p=0.14). <h3>Conclusions</h3> Compliance of APLS instructors with current international recommendations during simulated infant CPR is poor. The TT technique provided improved CD compliance, while the TF technique provided superior DC compliance. If this reflects current clinical practice, optimisation of performance to achieve international recommendations during infant CPR is called for.
Association between Lupus Psychosis and Antiribosomal P Protein Antibodies
Authors: Eloisa Bonfa, Steven J. Golombek, Lee D. Kaufman, Susan Skelly, Herbert Weissbach, Nathan Brot, Keith B. Elkon
Journal: New England Journal of Medicine (1987)

In 18 of 20 patients with psychosis secondary to systemic lupus erythematosus (SLE), autoantibodies to ribosomal P proteins were detected by immunoblotting and measured with a new radioimmunoassay using a synthetic peptide as antigen. The frequency of anti-P was not increased in patients with other central nervous system manifestations of SLE (3 of 20, by radioimmunoassay), in patients with transient behavioral abnormalities due to SLE (none of 8), in patients with psychosis who did not have SLE (none of 13), or in normal controls (none of 20). In four of five paired serum samples, anti-P-peptide antibody levels increased 5-fold to 30-fold during the active phase of lupus psychosis. Longitudinal studies of anti-P activity in two patients with psychosis revealed that anti-P levels increased before and during the active phases of psychosis but not during sepsis or other exacerbations of SLE, and that the elevations were selective for anti-P antibodies, as opposed to anti-DNA antibodies. Longitudinal studies of anti-P activity in two patients with anti-P but without psychosis showed less than threefold changes in anti-P levels despite exacerbations of disease. We conclude that anti-P is associated with lupus psychosis and that synthetic peptide antigens may be useful for the detection and measurement of autoantibodies to intracellular proteins.
On the Treatment of Diseased Joints by Escharotics
Authors: F. Kirkpatrick
Journal: BMJ (1867)

UANKAL. 1t77by what Ieans-the-bleedlng fromthcfemoral arter was so quickl ar- rested.Inmsituations, where admissible, no better method need be desired.In illutation of .the.happy results .ofacupressure, aided by perfect immunity from motion and t e avoidance of all dressings, I hope I may be pardoned for stating briefly the outline of one of my cases, although already published -elsewhere.At the Aberdeen hospital I performed amputation of thigh in a delicate, looking boy, six years of age, on ac- count of extensive disease of the knee-joint and the condition of the leg.The femoral and other two arteries were acupressed by the Aberdeen method, by the twist, and another vessel was compressed by the fourth method.The pins were withdrawn in forty-four hours, without being followed by a drop of blood, and, the.patient said, without causing any pain.After operation I thought it necessary to caution the little patient not to touch the acupressure pins, which he called the pins with the beautiful heads, and promised to give them-to him after their removal.*He took care not to touch them, or to allow any person except myself to do so, and, to his great delight, sent them home by his father for pre- servation until his return.Since the operation, the little boy has slept as well as ever he did in his life; has been anxious for his food; has had no uneasy sensation ofany kind, and has been in the highest ofspirits.The stump healed perfectly and throughout, either by immediate union or by primary adhesion.The healing must have been by one or other of