tbuckley/cabot-search huggingface dataset:
A Quantitative Comparison of Unipolar and Augmented Unipolar Limb Leads
Authors: ERNST SIMONSON, ANCEL KEYS
Journal: Circulation (1950)

Goldberger has claimed that his augmented unipolar limb leads (aV) are identical—except for a 50 per cent larger amplitude—and interchangeable with Wilson's original V leads, but this claim was not supported by quantitative evidence. The advantage of larger amplitudes explains the increasing preference for the aV leads. A quantitative comparison between V and aV leads revealed such tremendous variability of the augmentation ratio, both interindividual and between leads in the same individual, that standards obtained with V leads are not applicable to aV leads and vice versa. V leads and aV leads are not interchangeable.
THE BLANKET SPLIT SKIN GRAFT FOR COVERING LARGE GRANULATING AREAS
Authors: H. O. McPheeters
Journal: JAMA (1941)

So much has been written on the subject of skin grafting over granulating areas that further papers can do little more than repeat what has been said. The last presentation of Dr. Sumner L. Koch in Surgery, Gynecology and Obstetrics in January and February 1941 is so complete in every detail and covers every phase of the subject so well that little can be written that is really new. We do feel that in one particular we can add to the literature and for that reason are making this report.  Small granulating areas can be easily and quickly covered by most of the accepted technics with the razor grafts of Blair and Brown and their associates or with the small deep grafts of Davis. At times the implantation seed grafts of Braun can be used to advantage. In the resurfacing of large areas involving a complete loss of the skin
Tobacco and children.
Authors: J F Marx
Journal: Circulation (1994)

Arecent surge in public attention has focused on the future of smoking and the fate of the tobacco industry in the United States.The debate rages in the media, at Washington congressional hearings, and in homes and offices across the country.At the heart of the issue is smoking among America's young people.The tobacco industry spends $4.6 billion a year to advertise and promote its products.Tobacco companies say, resolutely, that they market their products only to adults.But tobacco advertising campaigns, such as Joe Camel, contradict that assertion.At a recent congres- sional hearing in Washington, Congressman Ron Wy- den, a father of two young children, lectured the CEOs of the seven major US tobacco companies: "In a few years, all of you ... are going to be using advertising like Joe Camel to try to hook my kids and addict them to tobacco products.And I just can't understand how each of you is engaged in an enterprise that is sure to kill some of our children.I hope today that you will tell us how you all can live with such a killing record on your conscience."The continuing "battle of the titans" between Con- gress and tobacco industry executives promises to de- liver more interesting political theater; however, when the dust settles, policymakers on the federal and state levels will have to get down to the business of considering legislation to help reduce the serious problem of tobacco use among young people.Helping to guide this rapidly changing political land- scape is the 23rd Surgeon General's Report on Smok- ing, Preventing Tobacco Use Among Young People, re- leased by US Surgeon General M. Joycelyn Elders, MD, on February 24, 1994.The report cites the more than
Endocrine function in homosexuals.
Authors: C. G. Ryrie, J. C. Brown
Journal: BMJ (1970)

trained.I shared his opinion then, and still do.It is common knowledge that many patients, who, on doctors' orders, have received months of heat, traction, massage, and exercises from a physiotherapist for a painful neck or back, eventually go off on their own and are put right by a treatment or two from a lay manipulator.Is there any good reason why these simple manoeuvres should not have been carried out at a doctor's request by the physiotherapist?However, the other agnect of the Question must be considered.The effectiveness of the physiotherapist also depends on doctors not sending along unsuitable cases.For examnle, they should no longer send patients along with a "frozen shoulder" for vain nlhvsiotherapy, when a few intra- articular injections of hydrocortisone provide the effective treatment.The coin has two sides.There would, in my opinion, be plenty enough physiotherapists to go round if on the one hand thev were sent only such cases as were likely to respond, and on the other they were taught as students a direct man- ual approach to all suitable lesions.-Iam, etc.,
Glutathione protects metastatic melanoma cells against oxidative stress in the murine hepatic microvasculature
Authors: Miren J. Anasagasti, Javier J. Martin, Lorea Mendoza, Elena Obrador, Jose M. Estrela, Robert S. McCuskey, Fernando Vidal-Vanaclocha
Journal: Hepatology (1998)

Calcein-labeled B16 melanoma (B16M) cells were injected intraportally, and in vivo video microscopy was used to study the distribution and damage of cancer cells arrested in the liver microvasculature over a period of 4 hours. The contribution of glutathione (GSH)-dependent antioxidant machinery to the possible oxidative stress-resistance mechanism of B16M cell was determined by in vitro incubation with the selective inhibitor of GSH synthesis L-buthionine (S,R)-sulphoximine (BSO) before B16M cell injection in untreated and 0.5-mg/kg lipopolysaccharide (LPS)-treated mice. In addition, untreated and LPS-treated isolated syngeneic hepatic sinusoidal endothelial cells (HSE) were used to determine in vitro their specific contribution to B16M cell damage. Trauma inherent to intrasinusoidal lodgement damaged 35% of B16M cells in both normal and LPS-treated mouse liver. The rest of the arrested B16M cells remained intact in normal liver for at least 4 hours, although their damaged cell percentage significantly (P < .05) increased since the second hour in normal mice injected with BSO-treated cells and since the first hour in LPS-treated mice given untreated cells. Recombinant human interleukin-1 receptor antagonist (rHuIL-1-Ra) given to mice 15 minutes before LPS significantly (P < .05) abrogated B16M cell damage. On the other hand, 40% of the B16M cells co-cultured with unstimulated HSE and 70% of the co-cultured with LPS-treated HSE became sensitive to endothelial cell-mediated damage after BSO treatment. These results demonstrate that a high intracellular level of GSH protects B16M cells from possible in vivo and in vitro sinusoidal cell-mediated oxidative stress, contributing to the mechanism of metastatic cell survival within the hepatic microvasculature.
Nail Changes in Functional and Organic Arterial Disease
Authors: Edward A. Edwards
Journal: New England Journal of Medicine (1948)

IT IS the purpose of this paper to show that the nails undergo specific changes in vasospastic and in organic peripheral arterial disease and are sensitive indicators of the severity of the underlying state.Raynaud1 made more detailed notation of such changes than subsequent writers did. Thus he stated that the nails may be cast off by vascular disease attacking them at their "root"; that growth of the nail stops during an episode of necrosis, and that they begin to grow when this episode is over, then showing a transverse depression; and that ulceration of a digit may give loss . . .
Do Tumour Characteristics and Disease Localization Predict Bevacizumab Activity in the Treatment of Metastatic Colorectal Cancer?
Authors: Umut Varol, Esin Oktay, Mustafa Yildirim, Zeki Surmeli, Nezih Meydan, Burcak Karaca, Bulent Karabulut, Ulus Sanli, Ruchan Uslu
Journal: Annals of Oncology (2013)
A FURTHER STUDY OF NITROGEN RETENTION IN THE BLOOD IN EXPERIMENTAL ACUTE NEPHRITIS
Authors: Howard T. Karsner, W. Denis
Journal: The Journal of Experimental Medicine (1914)

These studies, like all studies of the kidney, are difficult of interpretation because of the impossibility of producing a pure glomerular or pure tubular nephritis. Arsenic nephritis in its early stage is physiologically a vascular nephritis, but anatomically tubular, and shows in this stage almost no retention of nitrogen, although studies of urinary nitrogen indicate an increased catabolism. On the other hand, diphtheria nephritis in the early stages is anatomically a nephritis with marked involvement of the glomerulus anatomically, but it is physiologically a tubular form, and in this early stage there is little or no nitrogen retention although studies of metabolism indicate that protein catabolism is increased by the administration of diphtheria toxin. In both cases, however, there appears to come a time when the excreting power of the kidney is exhausted and nitrogen accumulation occurs in the blood. This is much less marked in the arsenic nephritis, with less tubular change, than in diphtheria toxin nephritis with its marked tubular degeneration. This same late accumulation of blood nitrogen is seen in immune serum nephritis, where the tubular changes are persistent and relatively more severe than the glomerular change. It might well be said that this is no argument for the influence of the tubules in the excretion of waste nitrogen because of the general exhaustion of the organism as a whole and of the kidney in particular, and that no positive conclusions can be drawn is indicated by the opening sentence of this summary. Tartrate nephritis was at first considered as purely tubular; but the appearance of occasional glomerular change, as mentioned by Wells in one of his animals, and the fact that the presence of precipitated albumen in the subcapsular space, pointed out by Pearce and Ringer, probably indicates an increased permeability of the tuft capillaries, all lead to the conclusion that although the tubular change predominates, there is, possibly, slight alteration of the glomerulus. This form of nephritis shows the most marked retention of nitrogen, persisting even though the glomeruli show almost no change, tending to clear up with the progress of time and evidently also with the repair of the tubular change, and bearing a direct relation to the dose of tartaric acid and presumably with the degree of tubular change. It must be remembered, however, that the nephritis in the cases of greatest retention is a very severe form, and this again clouds the physiological interpretation of the results. The study shows no reason for altering the conclusions of our earlier studies, but from the interpretation accorded above it appears to throw more stress on tubular change as determining nitrogen retention. It confirms in addition the value of the methods used for studies of this type.
Latest From Pertussis Front: Swedish Vaccine
Authors: Charles Marwick
Journal: JAMA (1992)

A NEW type of monovalent toxin-inactivated pertussis vaccine has shown evidence of efficacy in a phase 2 immunogenicity trial in Sweden, investigators say. A 3-year follow-up of vaccinees compared with age-matched controls shows the vaccine to be virtually 100% efficacious in preventing pertussis, they report. While encouraging, the evidence is only preliminary, says Birger Trollfors, MD, University of Göteborg, who is directing the study. He presented data on several clinical studies with this new vaccine at a meeting of the Food and Drug Administration's Advisory Committee on Vaccines and Related Products. <h3>Safe and Immunogenic</h3> The vaccine had already been shown safe and immunogenic in trials in adults, children, and infants in the United States and Sweden. In one Swedish trial, for example, 60 children between the ages of 18 months and 23 months, without a history of natural pertussis or pertussis vaccination, given two doses of this vaccine, had "pronounced
Time-Limited Certification
Authors: Edward Lifshitz
Journal: Annals of Internal Medicine (1991)

Letters1 March 1991Time-Limited CertificationEdward Lifshitz, MDEdward Lifshitz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-5-432_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The American Board of Internal Medicine position paper (1) on mandatory recertification as a prerequisite for maintaining diplomate standing raised several interesting and valid points. As a recent graduate of medical school and an internal medicine residency, I certainly agree that a process must exist to ensure that physicians and internists maintain a high level of proficiency. The public has a right to know that the physicians they entrust with their medical problems are competent. Recertification as a prerequisite for maintaining diplomate status is a viable option.My concern is with the physicians affected by the recertification...Reference1. GlassockBensonCopeland RJR. Time-limited certification and recertification: the program of the American Board of Internal Medicine. The Task Force on Recertification. Ann Intern Med. 1991;114:59-62. LinkGoogle Scholar1. GlassockBensonCopeland RJR. Time-limited certification and recertification: the program of the American Board of Internal Medicine. The Task Force on Recertification. Ann Intern Med. 1991;114:59-62. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Staten Island University Hospital Staten Island, NY 10305 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByWhat is a specialist? The role of board certification in occupational medicine 1 March 1991Volume 114, Issue 5Page: 432-433KeywordsGraduate medical educationResidency Issue Published: 1 March 1991 PDF DownloadLoading ...
Leukotriene-Receptor Inhibition for the Treatment of Systemic Mastocytosis
Authors: Jakub Tolar, Whitney D. Tope, Joseph P. Neglia
Journal: New England Journal of Medicine (2004)

To the Editor: Systemic mastocytosis is an uncommon and potentially misdiagnosed condition. Its hallmark is the accumulation and abnormal proliferation of mast cells in various tissues. A two-month-old boy was referred to our facility with numerous bullae on the skin and unilateral periorbital cellulitis. The child was inconsolable, and his skin lesions, which had been present since birth, progressed into subcutaneous nodules, plaques, and tumors, which were excoriated. He had hepatomegaly and wheezing. Findings on examination of biopsy specimens of the skin and bone marrow were consistent with the diagnosis of systemic mastocytosis. There were no bony lesions, and there . . .
Benefits and Adverse Events Among Elderly Patients Receiving Concurrent Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer: Analysis of the Okayama Lung Cancer Study Group Trial 0007
Authors: Nagio Takigawa, Katsuyuki Kiura, Yoshihiko Segawa, Katsuyuki Hotta, Akihiko Tamaoki, Yoshiyuki Tokuda, Takuya Nagata, Kazuhiko Watanabe, Kenichi Gemba, Tomonori Moritaka, Naokatsu Horita, Hiromasa Takeda, Niro Okimoto, Mitsuhiro Takemoto, Keitaro Matsuo, Tetsu Shinkai, Masahiro Tabata, Hiroshi Ueoka, Susumu Kanazawa, Mitsune Tanimoto
Journal: Journal of Thoracic Oncology (2011)
A Solution For Too Many Papers
Authors: AMIR S. ALI
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 February 1982A Solution For Too Many PapersAMIR S. ALI, M.D.AMIR S. ALI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-2-260_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In this age when everybody has suddenly decided that it is about time that his or her name appeared in print, we are bombarded with a storm of medical journals repeating the same clinical topics. For years, the major emphasis in publishing had been on "new and useful" information. That has changed drastically. A wide and lucrative pharmaceutical advertisement market has been matched perfectly with this mass desire for "going to print." Everybody wants to write, everybody is writing; although many articles are rejected by many "inconsiderate" journals, eventually most get published. Many good physicians are hardly... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: AMIR S. ALI, M.D.Affiliations: Wright State University School of Medicine VA Medical Center Dayton, OH 45428 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1982Volume 96, Issue 2Page: 260-260KeywordsStorms ePublished: 1 December 2008 Issue Published: 1 February 1982 PDF downloadLoading ...
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
Authors: D Lostanlen, G Lenoir, J C Kaplan
Journal: Journal of Clinical Investigation (1981)

Recessive congenital methemoglobinemia (RCM) is due to the homozygous deficiency of NADH-cytochrome b5 reductase (EC 1.6.2.2.). In type I disease, in which the patients are only methemoglobinemic, the enzyme defect is fully expressed in the erythrocytes, whereas the leukocytes are much less affected. In type II disease, in which the patients are, in addition, mentally retarded, the defect is generalized to all the tissues including cultured fibroblasts. In the present study we have investigated Epstein-Barr virus (EBV) transformed lymphoid cell lines (LCL) derived from patients with both types of cytochrome b5 reductase deficiency and from nondeficient individuals. The total cytochrome b5 reductase activity of the control LCL was found to be similar whatever the LCL origin, except for one lymphoma line (Daudi). The enzyme from the control LCL (c 252/B 95) was found to be immunologically related to the human soluble erythrocyte cytochrome b5 reductase, indicating that it is the product of the same gene: the DIA1 (diaphorase) locus. The LCL derived from one patient with the type I disease and two patients with the type II disease were investigated.l In the former the defect was expressed to a lesser degree than in the cases with mental retardation in which the defect was much pronounced, and involved both the mitochondrial and the microsomal fraction. This indicated that all the subcellular forms of the cytochrome b5 reductase are under the same genetic control. Altogether, these data show that the LCL are a favorable material for studying both types of cytochrome b5 reductase deficiency and for investigating in depth the molecular aspects of this metabolic disease.
Targeting of Adenovirus Vectors to the LRP Receptor Family With the High-affinity Ligand RAP via Combined Genetic and Chemical Modification of the pIX Capsomere
Authors: Stéphanie Corjon, Andreas Wortmann, Tatjana Engler, Nico van Rooijen, Stefan Kochanek, Florian Kreppel
Journal: Molecular Therapy (2008)

Adenovirus (Ad) vector targeting requires presentation of specific ligands on the virion's surface. Geneti-chemical targeting is based on the genetic introduction of cysteine residues bearing reactive thiol groups into solvent-accessible capsomeres of the virion and subsequent chemical coupling of ligands. Here, we exploited this technology to modify the pIX capsomere with high-affinity ligands. Genetic introduction of C-terminal cysteines to pIX allowed for specific coupling of full-length proteins to the virion, while not affecting vector production. Direct comparison of the two high-affinity ligands receptor- associated protein (RAP) and transferrin (Tf) revealed that targeting after coupling of a high-affinity ligand to pIX presumably requires release of the ligand from its receptor after cell entry. In addition, data obtained by live cell imaging of labeled vector particles demonstrated that coupling of very large proteins to pIX can impair intracellular vector particle trafficking. Finally, we demonstrate that the geneti-chemical targeting technology is suitable for in vivo targeting to liver after intravenous injection. Our data provide significant insight into basic requirements for successful targeting of pIX-modified Ad vectors.
Correction: Human Immunodeficiency Virus (HIV) Infection and the Kidney
Authors: Richard J. Glassock
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 March 1990Correction: Human Immunodeficiency Virus (HIV) Infection and the KidneyRichard J. Glassock, MDRichard J. Glassock, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-3-112-6-476 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Please note the correct citation (1) for the work cited as unpublished observations (page 35, second paragraph) in our article (2) appearing in the 1 January 1990 issue....References1. Tang W, Feinstein E, and Massry S. Hyponatremia in patients with acquired immunodeficiency syndrome (AIDS) and the AIDS related complex (ARC). Kidney Int. 1988;33:211. Google Scholar2. Glassock R, Cohen A, Danovitch G, and Parsa K. Human immunodeficiency virus (HIV) infection and the kidney. Ann Intern Med. 1990;112:35-49. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Richard J. Glassock, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1990Volume 112, Issue 6Page: 476-476KeywordsHIVHIV infectionsKidneys ePublished: 1 December 2008 Issue Published: 15 March 1990 PDF downloadLoading ...
Assessment of right ventricular function during supine bicycle exercise after Mustard's operation.
Authors: L N Benson, J Bonet, P McLaughlin, P M Olley, D Feiglin, M Druck, G Trusler, R D Rowe, J Morch
Journal: Circulation (1982)

Right ventricular (RV) performance during supine bicycle exercise was evaluated by gated equilibrium nuclear angiography in 19 clinically well children with d-transposition of the great arteries (d-TGA), 6.4 +/- 2.7 years after Mustard's operation. Comparisons were made between rest and peak exercise. The mean resting ejection fraction was 44 +/- 12% (range 30-75%) and was unchanged at peak exercise. Eight children had a normal ejection fraction response, whereas 11 children had either no increase or a decrease in ejection fraction. Relative end-diastolic volumes decreased from resting values in all patients who had an abnormal ejection fraction response. Among patients whose ejection fraction increased, the end-diastolic volume increased in three, decreased in four and was unchanged in one at peak exercise. Heart rate increased 84% (range 52-135%) and systolic blood pressure increased 16% (range 0-28%) at peak exercise. There was no correlation between exercise response and age at surgery or interval since surgery. These data indicate that clinically well children after Mustard's procedure may have abnormal right ventricular function under stress, raising concerns about the ability of the right ventricle to function as the systemic ventricle.