Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis
Authors: Jeong H. Yun
Journal: Annals of Internal Medicine (2011)

Letters5 July 2011Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic SclerosisJeong H. Yun, MD, MPHJeong H. Yun, MD, MPHFrom Albert Einstein Medical Center, Philadelphia, PA 19141.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-1-201107050-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The case report by Guiducci and colleagues (1) presents the therapeutic potential of autologous mesenchymal stem cells (MSCs) for patients with systemic sclerosis. The authors suggest that factors expressed from MSCs and the ability of MSCs to differentiate into endothelial and vascular smooth muscle cells account for the observed revascularization. The potential immunosuppressive effect of MSCs also may have contributed to the positive outcome.It is well-documented that MSCs suppress inflammation through soluble factors and direct physical contact, affecting the innate as well as the adaptive immune system (2). Researchers report that patients with systemic sclerosis may ...References1. Guiducci S, Porta F, Saccardi R, Guidi S, Ibba-Manneschi L, Manetti M, et al. Autologous mesenchymal stem cells foster revascularization of ischemic limbs in systemic sclerosis: a case report. Ann Intern Med. 2010;153:650-4. [PMID: 21079220] LinkGoogle Scholar2. Kode JA, Mukherjee S, Joglekar MV, Hardikar AA. Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy. 2009;11:377-91. [PMID: 19568970] CrossrefMedlineGoogle Scholar3. Bocelli-Tyndall C, Bracci L, Spagnoli G, Braccini A, Bouchenaki M, Ceredig R, et al. Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in vitro. Rheumatology (Oxford). 2007;46:403-8. [PMID: 16920750] CrossrefMedlineGoogle Scholar4. Del Papa N, Quirici N, Soligo D, Scavullo C, Cortiana M, Borsotti C, et al. Bone marrow endothelial progenitors are defective in systemic sclerosis. Arthritis Rheum. 2006;54:2605-15. [PMID: 16868984] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Albert Einstein Medical Center, Philadelphia, PA 19141.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAutologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis Serena Guiducci , Francesco Porta , Riccardo Saccardi , Stefano Guidi , Lidia Ibba-Manneschi , Mirko Manetti , Benedetta Mazzanti , Simone Dal Pozzo , Anna Franca Milia , Silvia Bellando-Randone , Irene Miniati , Ginevra Fiori , Rossana Fontana , Laura Amanzi , Francesca Braschi , Alberto Bosi , and Marco Matucci-Cerinic Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis Serena Guiducci , Mirko Manetti , and Marco Matucci-Cerinic Metrics Cited bySuccessful mesenchymal stem cell treatment of leg ulcers complicated by Behcet diseaseActivation of Human Mesenchymal Stem Cells Impacts Their Therapeutic Abilities in Lung Injury by Increasing Interleukin (IL)-10 and IL-1RN Levels 5 July 2011Volume 155, Issue 1Page: 65KeywordsAngiogenesisConflicts of interestImmunosuppressivesInflammationInnate immune systemMesenchymal stem cellsRevascularizationSclerodermaSmooth muscle cells ePublished: 5 July 2011 Issue Published: 5 July 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...