Methimazole, Carbimazole, and Congenital Skin Defects
Authors: CORNELIS P. VAN DIJKE
Journal: Annals of Internal Medicine (1987)

Brief Reports1 January 1987Methimazole, Carbimazole, and Congenital Skin DefectsCORNELIS P. VAN DIJKE, M.D., Ph.D., ROB J. HEYDENDAEL, M.D., MARTIN J. DE KLEINE, M.D.CORNELIS P. VAN DIJKE, M.D., Ph.D., ROB J. HEYDENDAEL, M.D., MARTIN J. DE KLEINE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-1-60 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperthyroidism during pregnancy generally is treated with antithyroid drugs. In their reviews of the literature, Burrow (1) and Cooper (2) have advised against the use of methimazole (thiamazole) in pregnant women with hyperthyroidism because two studies reported an association of the drug with congenital skin defects (aplasia cutis). In 1972, Milham and Elledge (3) briefly described the cases of 12 patients with congenital scalp defects and noted that in three cases, one of which included a pair of fraternal twins, the mother had taken methimazole during pregnancy. In 1975, Mujtaba and Burrow (4) reported data from their study on the...References1. BURROW G. The management of thyrotoxicosis in pregnancy. N Engl J Med. 1985;313:562-5. CrossrefMedlineGoogle Scholar2. COOPER D. Antithyroid drugs. N Engl J Med. 1984;311:1353-62. CrossrefMedlineGoogle Scholar3. MILHAM S and ELLEDGE W. Maternal methimazole and congenital defects in children. Teratology. 1972;5:125. CrossrefGoogle Scholar4. MUJTABA Q and BURROW G. Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole. Obstet Gynecol. 1975;46:282-6. MedlineGoogle Scholar5. BACHRACH L and BURROW G. Aplasia cutis congenita and methimazole [Letter]. Can Med Assoc J. 1984;130:1264. MedlineGoogle Scholar6. MANNINO F, JONES K, and BENIRSCHKE K. Congenital skin defects and fetus papyraceus. J Pediatr. 1977;91:559-64. CrossrefMedlineGoogle Scholar7. JANSSON R, DAHLBERG P, and LINDSTRÖM B. Comparative bioavailability of carbimazole and methimazole. Int J Clin Pharmacol Ther Toxicol. 1983;21:505-10. MedlineGoogle Scholar8. VANDENBROUCKE J. A shortcut method for the calculation of the 95 per cent confidence interval of the Standardized Mortality Ratio. Am J Epidemiol. 1982;115:303-4. CrossrefGoogle Scholar9. MOMOTANI N, ITO K, HAMADA N, BAN Y, NISHIKAWA Y, and MIMURA T. Maternal hyperthyroidism and congenital malformation in the offspring. Clin Endocrinol (Oxf). 1984;20:695-700. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CORNELIS P. VAN DIJKE, M.D., Ph.D.; ROB J. HEYDENDAEL, M.D.; MARTIN J. DE KLEINE, M.D.Affiliations: Netherlands Centre for Monitoring of Adverse Reactions to Drugs Leidschendam Carolus Hospital 's-Hertogenbosch University Hospital of Amsterdam Amsterdam the Netherlands. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGraves' DiseaseRecent Advances in Ester Synthesis by Multi-Component Reactions (MCRs): A ReviewPrimer on Graves' Disease: What the Ophthalmologist Should Know and DoGraves' diseaseTeratogen update: Antithyroid medicationsTreatment of Graves' hyperthyroidism with thionamides: a position paper on indications and safety in pregnancyEndocrine Diseases of PregnancyRiesgo prenatal en el hipertiroidismo. 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