Immune Hemolysis Due to Hydralazine
Authors: ALLAN A. ORENSTEIN
Journal: Annals of Internal Medicine (1977)

Letters1 April 1977Immune Hemolysis Due to HydralazineALLAN A. ORENSTEIN, M.D., VINCENT YAKULIS, B.S., JOSEPH EIPE, M.D., NICOLAS COSTEA, M.D.ALLAN A. ORENSTEIN, M.D., VINCENT YAKULIS, B.S., JOSEPH EIPE, M.D., NICOLAS COSTEA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-4-450 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA number of adverse effects have been reported in association with hydralazine therapy including hyperdynamic circulation with increased heart rate and cardiac output, an acute rheumatoid state resembling disseminated lupus erythematosus, peripheral neuropathy, and various blood dyscrasias (1). Although a number of drugs have been shown to trigger immune hemolytic anemia (2, 3), hydralazine was not one of them; however, we have recently observed a patient who developed Coombs' positive hemolysis while receiving small doses of this drug for mild hypertension.A 63-year-old white man was referred to us in July 1976 for evaluation of anemia. He was asymptomatic, without...References1. KOCH-WESER J: Drug therapy. Hydralazine. N Engl J Med 295:320-323, 1976 CrossrefMedlineGoogle Scholar2. GARRATHY G and PETZ L: Drug induced immune hemolytic anemia. Am J Med 58:398-407, 1975 CrossrefMedlineGoogle Scholar3. DEGRUCHY G: Drug Induced Blood Disorders. Oxford, Blackwell Scientific Publications, 1975, p. 167 Google Scholar4. LIU C and ADLER F: Immunologic studies on drug addiction. I. Antibodies reactive with methadone and their use for detection of the drug. J Immunol 111:472-477, 1973 CrossrefMedlineGoogle Scholar5. GOLD E and FUDENBERG H: Chromic chloride: a coupling reagent for passive hemagglutination reactions. J Immunol 99:859-866, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALLAN A. ORENSTEIN, M.D.; VINCENT YAKULIS, B.S.; JOSEPH EIPE, M.D.; NICOLAS COSTEA, M.D.Affiliations: Hematology-Oncology Section UCLA San Fernando Valley Medical Program Sepulveda, CA 91343 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs that have been shown to cause drug-induced immune hemolytic anemia or positive direct antiglobulin tests: some interesting findings since 2007An update on drug-induced immune hemolytic anemiaDrug-Induced Immune Hemolytic AnemiaAutoantibody formation after alloimmunization: are blood tranfusions a risk factor for autoimmune hemolytic anemia?Drug-induced red cell dyscrasiasHydralazine binds covalently to complement component C4Anaemia in the Hydrallazine-Induced Lupus SyndromeAnti-Nomifensine Antibody Causing Immune Hemolytic Anemia and Renal FailureHypocomplementemia in hydralazine-associated systemic lupus erythematosusHypotensive drugs 1 April 1977Volume 86, Issue 4Page: 450-451KeywordsAnemiaBloodCardiac outputDrugsHeart rateHemolytic anemiaHypertensionLupus erythematosusPeripheral neuropathy ePublished: 1 December 2008 Issue Published: 1 April 1977 PDF downloadLoading ...