tbuckley/cabot-search huggingface dataset:
Scalp Pustules in a Patient Receiving Chemotherapy
Authors: Hsien-Yi Chiu, Hsien-Ching Chiu
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SEROLOGIC STRAIN DIFFERENTIATION IN TRACHOMA
Authors: Roger L. Nichols, Dorothy E. McComb
Journal: The Journal of Experimental Medicine (1964)

An in vitro test for the differentiation of trachoma strain isolates was described. The method was based on absorption of trachoma antiserum followed by immunofluorescent staining of individual trachoma strains. Nineteen trachoma strains were studied; two main types were identified. Evidence for quantitative and qualitative antigenic variation between the two types was presented. The limitations in practice and in theory of the test were emphasized.
Epidemiology of hepatitis B and C viral infections in minorities of thrace: immigrants from the former ussr and moslem religious minority in relation to the general population of thrace
Authors: K.M. Papoutselis, S.S. Kotsiou, G.H. Zacharakis, N.V. Vafeiadis, F.V. Tzara, E.I. Pouliou
Journal: Journal of Hepatology (2001)
The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma
Authors: Lee M Jampol, Claudia S Moy, Timothy G Murray, Sandra M Reynolds, Daniel M Albert, Andrew P Schachat, Kenneth R Diddie, Robert E Engstrom, Paul T Finger, Kenneth R Hovland, Leonard Joffe, Karl R Olsen, Craig G Wells
Journal: Ophthalmology (2002)
THE USE OF FRENQUEL IN THE TREATMENT OF DISTURBED PATIENTS WITH PSYCHOSES OF LONG DURATION
Authors: F. RINALDI, L. H. RUDY, H. E. HIMWICH
Journal: American Journal of Psychiatry (1955)

In this double-blind study of the effect of Frenquel on 39 chronically hospitalized disturbed psychotic patients, the investigators were entirely unaware of whether the patients were receiving Frenquel or the placebo until after they had committed themselves on the patient's status. Despite the long-standing nature of the disturbances in behavior significant improvement was observed in a large proportion of the patients with various types of schizophrenic reactions. We feel these results are most encouraging for further use of this drug in patients with psychoses.
A Rational Approach to a Common Goal: The Equitable Distribution of Organs for Transplantation
Authors: Felix T. Rapaport
Journal: JAMA (1987)

The advent of brain death criteria and the increasing use of a new immunosuppressive agent, cyclosporine, have produced a quantum leap in the applicability of organ transplantation to the treatment of human disease.<sup>1</sup>Although the Uniform Anatomical Gift Act passed by Congress and adopted by all 50 states<sup>2</sup>has provided a legal basis for organ donation since 1973, there has been an increasingly severe shortage of organs for transplantation.<sup>3</sup>The growing acuteness of the problem, particularly with regard to kidney, heart, and liver transplantation, prompted congressional enactment of a National Organ Transplantation Act in 1984. The key element motivating this action was the universally accepted desirability of equitable distribution of all available organs in the United States. Unfortunately, government involvement in the practice of medicine is often followed by a deluge of well-intended but not necessarily well-informed regulations. Such regulations can, in the long run, produce results
Kinetic Studies of Purified Leukocyte and Red Cell Pyruvate Kinase.
Authors: Robert H. Bigley
Journal: Annals of Internal Medicine (1965)

s1 November 1965Kinetic Studies of Purified Leukocyte and Red Cell Pyruvate Kinase.Robert H. Bigley, M.D., Jose O. Campos, M.D., Robert D. Koler, M.D., F.A.C.P.Robert H. Bigley, M.D.Search for more papers by this author, Jose O. Campos, M.D.Search for more papers by this author, Robert D. Koler, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-912_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudies of purified leukocyte and red cell pyruvate kinase (PK) show different kinetics, suggesting that they are different enzymes with different mechanisms of action. In the forward reaction, the two substrates, adenosine diphosphate (ADP) and phosphoenolpyruate (PEP) combine with leukocyte PK in a noncompulsory or independent fashion with Km's very similar to those reported for rabbit muscle PK. Red cell enzyme kinetics, on the contrary, suggest compulsory combination with substrates. Since the affinity for one substrate is modified by the concentration of the second substrate, comparison of normal and mutant red cell enzyme must be done under identical conditions. Purified... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 912-912KeywordsAdenosine diphosphateAttentionEnzymesMuscle cellsPostexposure prophylaxisPyruvateRabbits Issue Published: 1 November 1965 PDF DownloadLoading ...
Marine Omega-3 Fatty Acids and Atherosclerosis
Authors: RICHARD C. BECKER
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 April 1988Marine Omega-3 Fatty Acids and AtherosclerosisRICHARD C. BECKER, M.D., JEANNE M. CORRAO, R.N.RICHARD C. BECKER, M.D.Search for more papers by this author, JEANNE M. CORRAO, R.N.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-641_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Intracoronary thrombosis is a critical component in the pathogenesis of acute myocardial infarction and may also participate in atherogenesis. Therefore, intrinsic abnormalities of the hemostatic and fibrinolytic systems have been studied in patients with coronary artery disease. Atherosclerosis impairs local fibrinolysis by altering vascular endothelial cell structure and function. Systemic fibrinolytic mechanisms may also be defective as a result of abnormal tissue plasminogen activator release (1) and increased tissue plasminogen activator inhibitor concentration (1, 2). Von Schacky's article (3) on omega-3 fatty acids cites Barcelli and associates (4) and states ". . . plasma levels of vascular...References1. HAMSTEN A, WIMAN B, DEFAIRE U, and BLOMBACK M. Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. N Engl J Med. 1985;313:1557-63. CrossrefMedlineGoogle Scholar2. MEHTA J, MEHTA P, LAWSON D, and SALDEEN T. Plasma tissue plasminogen activator inhibitor levels in coronary artery disease: correlation with age and serum triglyceride concentrations. J Am Coll Cardiol. 1987;9:263-8. CrossrefMedlineGoogle Scholar3. VON SCHACKY C. Prophylaxis of atherosclerosis with marine omega-3 fatty acids: a comprehensive strategy. Ann Intern Med. 1987;107:890-9. LinkGoogle Scholar4. BARCELLI U, GLAS-GREENWALT P, and POLLAK V. Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis. Thromb Res. 1985;39:307-312. CrossrefMedlineGoogle Scholar5. BACHMAN F and KRUITHOF E. Tissue plasminogen activator: chemical and physiologic aspects. Semin Thromb Hemostas. 1984;10:6-17. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD C. BECKER, M.D.; JEANNE M. CORRAO, R.N.Affiliations: University of Massachusetts Medical Center Worcester, MA 01605 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1988Volume 108, Issue 4Page: 641-641KeywordsAtherosclerosisBlood plasmaEndothelial cellsFatty acidsFibrinolysisHemostaticsPathogenesisStable coronary artery diseaseThrombosisTissue plasminogen activator ePublished: 1 December 2008 Issue Published: 1 April 1988 PDF downloadLoading ...
Thyroid-Stimulating Activity and Chorionic Gonadotropin
Authors: Bruce C. Nisula, Jean-Marie Ketelslegers
Journal: Journal of Clinical Investigation (1974)

The nature of the substance with thyroid-stimulating activity (TSA) present in human chorionic gonadotropin (hCG) prepared from pregnancy urine was investigated. In the mouse thyrotropin bioassay, the characteristic maximum of blood radioactivity obtained with the TSA in hCG preparations occurred after that obtained with pituitary thyrotropin (hTSH) but before that obtained with long-acting thyroid stimulator. Antiserum to the α subunit of hCG produced significant neutralization of the TSA in hCG. Significant antagonism of hTSH biologic activity was achieved with certain doses of hCG, suggesting that the TSA in hCG was a partial agonist of hTSH. This antagonism was neutralized by antiserum to the β subunit of hCG. These immunologic results suggest that the substance with TSA in hCG preparations contains antigenic determinants similar to those of both the α and the β subunit of hCG. Amounts of highly purified hCG and crude commercial hCG of equal immunologic activity were biologically indistinguishable in the bioassay for TSA. Both hCG immunoreactivity and the TSA in hCG adsorbed to concanavalin A and eluted with 0.2 M methyl α-D-glucopyranoside. These results are consistent with the hypothesis that TSA is an intrinsic property of hCG or of a glycoprotein molecule physicochemically, biologically, and immunologically similar to hCG.
Alcoholism and Orthotopic Liver Transplantation
Authors: Daniel K. Flavin
Journal: JAMA (1988)

IT HAS been 31 years since the American Medical Association declared alcoholism to be within the scope of medical practice. Although great strides have been made in the diagnosis and management of this illness since then, a recent court case in the state of Michigan reminds us that continued vigilance is the cornerstone of progress. The case involves the denial of authorization of Michigan Medicaid funding for an orthotopic liver transplant in a young alcoholic man terminally ill with end-stage alcohol-related cirrhosis. There were no contraindications to surgery and sobriety was documented for at least six months; nevertheless, a request for funds was twice denied. Both of these decisions were based on a Michigan Department of Social Services requirement mandating a two-year period of abstinence before transplantation. Although the court challenge resulted in a favorable decision for the patient, he died of complications directly related to his liver disease before
The common cold: the effect of hot humid air on the nasal mucosa
Authors: L. Katzman
Journal: JAMA (1994)

<h3>To the Editor.</h3> —For more than 68 years, Kaz Inc has manufactured quality health care products, namely, vaporizers and humidifiers, to help relieve the symptoms of cold and flu. We are deeply disappointed in the recent publication of the two studies<sup>1,2</sup>on the effect of inhaling heated vapor and hot humidified air on symptoms of the common cold. Both studies used a specialized steam device called the Rhinotherm, which shoots warm moist air directly up the nose through a nozzle. This device is not typical of the vaporizers and humidifiers commonly found in the marketplace. We strongly object to the broad objectives and conclusions set forth in the studies. We hope thatTHE JOURNALwill clarify the following points in the interest of accuracy and public safety: (1) The results of the studies were specific to the use of the Rhinotherm, not all vaporizers and humidifiers. (2) The Rhinotherm
Human Growth: A Comprehensive Treatise
Authors: Hugh A. Carithers
Journal: JAMA (1987)

These three volumes constitute a major contribution to researchers and physicians interested in the growth and development of humans. In a convenient manner, they bring together the results of a vast amount of research that deals directly with the subject and should be especially valuable for pediatricians, obstetricians, and family physicians. The volumes contain 59 chapters written by more than 80 authors, approximately half of whom are foreign authorities. Volume 1 is entitled<i>Developmental Biology, Prenatal Growth</i>; volume 2,<i>Postnatal Growth, Neurobiology</i>; and volume 3,<i>Methodology, Ecological, Genetic and Nutritional Effects on Growth</i>. They are available individually. The books are handsomely bound and nicely printed in double-column style. They contain more than 1600 pages and could have been produced as one volume, thus reducing cost, perhaps by half, but separate volumes make for easy handling, without uncomfortable weight. Most of the chapters are not pedantic and are pleasant to read,
A purchaser perspective of managing new drugs: interferon beta as a case study
Authors: T Walley, S Barton
Journal: BMJ (1995)

Many new drugs in the future will be very expensive and have major resource implications. Given current structures and legislation covering the prescribing of drugs, there are no clear means of controlling the use of these drugs to avoid diverting money away from other health care services and into drug treatment. This paper considers what mechanisms might be used by a purchaser to manage the introduction of an expensive new drug and uses interferon beta-1b for treating multiple sclerosis as an example. The most likely mechanism is the prescribing of the drug by a general practitioner on the advice of a neurologist. This would achieve a good benefit for the resources invested but would not control total expenditure. Devolving a limited budget for the drug to a specialist centre so that neurologists may prescribe it directly would be preferable, as this would link clinical, prescribing, and budgetary responsibility. These issues need to be addressed urgently by purchasers if major disruptions of services are to be avoided.
Pseudoaneurysm of the Left Ventricle
Authors: CHRISTINE Z. DICKINSON, ROBERT H. CHRISTENBERRY, THOMAS W. ERTZNER, THOMAS A. POWERS, GOTTLIEB C. FRIESINGER, MARTIN P. SANDLER, C LEON PARTAIN
Journal: Clinical Nuclear Medicine (1984)

False aneurysm of the left ventricle is a rare complication of myocardial infarction with a high propensity for late rupture. Timely diagnosis is important and surgical repair is curative in a high percentage of patients. A case in which a false left ventricular aneurysm was recognized by first pass radionuclide angiography and confirmed by contrast ventriculography is reported. Surgery was then performed successfully. The diagnosis of false left ventricular aneurysm using radionuclide angiography, as well as other diagnostic imaging modalities, is discussed.
Epiglottitis in an Adult
Authors: Venkata Angirekula, Ashrit Multani
Journal: New England Journal of Medicine (2015)

A previously healthy 65-year-old woman presented with a 7-day history of throat pain, difficulty swallowing, muffled voice, and fevers. Lateral soft-tissue radiography of the neck showed the “thumb sign,” indicating a swollen epiglottis, suggestive of epiglottitis.
P1-084: Mammalian target of rapamycin (mTOR) inhibition by RAD001 in patients (pts) with reccurent non-small cell lung cancer (NSCLC): Use of 18F fluorodeoxyglucose positron-emission tomography (FDG-PET) in evaluation of the pharmacodynamic effect
Authors: Lucia Nogova, Thomas Zander, Stefan H. Gross, Theodore Pellas, Wendy Hayes, Roman Thomas, Markus Dietlein, Giuseppe Giaccone, Otto Hoekstra, Juergen Wolf
Journal: Journal of Thoracic Oncology (2007)
Suppression of antigen-specific T- and B-cell responses by intranasal or oral administration of recombinant Bet v 1, the major birch pollen allergen, in a murine model of type I allergy
Authors: Ursula Wiedermann, Beatrice Jahn-Schmid, Barbara Bohle, Andreas Repa, Harald Renz, Dietrich Kraft, Christof Ebner
Journal: Journal of Allergy and Clinical Immunology (1999)
GW25-e3502 Takotsubo cardiomyopathy are easier to occur in the patients with chronic circulatory diseases
Authors: Chong Jingmin, Cao Xiancun, Zhang Lin, Hou Hongjian, Zhang Yan, Xi Jiao, Wu Liang, Geng Yao, Guo Mengqi, Sun Hong
Journal: Journal of the American College of Cardiology (2014)
Abstract B7: Use of ponatinib to restrict growth of non-small cell lung cancer (NSCLC) cells overexpressing FGFR1
Authors: Mingqiang Ren, Mei Hong, Suiquan Wang, John Cowell, Zhonglin Hao
Journal: Clinical Cancer Research (2012)

Abstract For advanced stage NSCLC, targeted molecular therapy based on an understanding of the oncogenic driver mutations is emerging as the new front line care replacing chemotherapy where the oncogenic driver mutation is clearly defined e.g EGFR mutation or EML4-ALK translocation. However, the proportion of patients that fall into this category is small and are mostly non-smokers with adeno histology. Identifying new oncogenic drivers in NSCLC is therefore paramount. In our initial Oncomine database search, we found that FGFRs are overexpressed in various NSCLC tissue specimens. Quantitative real time PCR and Western blot analysis subsequently confirmed overexpression of FGFR1 in about one fourth of NSCLC cell lines analyzed. Among these, H520, H1299 and A549 had significantly higher levels of FGFR1 expression compared to H3122 which carries an EML4-ALK fusion protein. Real time PCR also demonstrated FGFR1 overexpression compared to normal human bronchial epithelial cells transformed by Herpes Papillary Virus E6/E7 (HBE4). Furthermore, as a sign of epithelial to mesenchymal transition, these cells switched from expressing the FGFR1 3b to the 3c form. In a colonogenic assay the growth of cells carrying FGFR1 overexpression/activation is markedly suppressed by ponatinib, a pan FGFR inhibitor as expected. Similarly, ponatinib treatment of NSCLC cell lines using 1 μM concentrations effectively suppressed the phosphorylation level of FGFR1 and its known down-stream targets including pSrc and pPLCγ without significant impact on the total protein expression. Treatment of these cells harboring FGFR1 activation with ponatinib arrests cells at the G1 phase as shown in the flow cytometry analysis. To determine whether the observed effects are specifically due to the suppression of FGFR1 by ponatinib, an shRNA knock down of FGFR1 was performed. Consistently, shFGFR1 significantly inhibited the growth of H520 and H1299 cells, whereas knock-down did not significantly affect the growth of H3122. Similar to ponatinib treatment, shFGFR1 caused more cells to arrest in G1 phase. In a MTT assay, ponatinib synergistically induced growth suppression/killing of H520 cells with cisplatin and paclitaxel. We are currently determining whether ponatinib is effective in inhibiting NSCLC cells derived directly from freshly resected lung cancer specimens. In conclusion, the FGFR1 pathway is constitutively active in a proportion of NSCLC cell lines and ponatinib is a potent inhibitor of constitutive FGFR1 activation. Ponatinib is potentially useful as a molecularly targeted agent against this portion of NSCLC when used alone or in combination with traditional chemotherapy regimens.
Failure of Lymphocytes from Hypogammaglobulinaemic Subjects to Transform in Culture
Authors: M. W. Elves, S. Roath, M. C. G. Israels
Journal: BMJ (1964)

Rapid and accurate diagnosis of cardiovascular device infection remains a challenge in the clinic. Anatomic imaging tools such as echocardiography and cardiac CT or CT angiography are the first-line modalities for clinically suspected endocarditis given their ability to detect vegetation and perivalvular complications. Accumulating data suggest that functional imaging with <sup>18</sup>F-FDG PET/CT has unique merits over anatomic imaging and could potentially diagnose early cardiac device infection before morphologic damage ensues and identify infection sources or bacterial emboli in the rest of the body. Although an abnormal finding on <sup>18</sup>F-FDG PET/CT was added to the 2015 guidelines of the European Society of Cardiology as a major criterion for the diagnosis of device-related and prosthetic valve endocarditis, that addition has not been incorporated in the U.S. guidelines. Beyond these clinically available imaging tools, attempts have been made to develop bacteria-targeting tracers for specific infection imaging, which include tracers of bacterial maltodextrin transporter, bacterial thymidine kinase, antibiotics, antimicrobial peptides, bacterial antibodies, bacteriophages, and bacterial DNA/RNA hybrid nucleotide oligomers. Most of the tracers have been studied only in experimental animals, except for radiolabeled antibiotics, which have been examined in humans without success in clinical translation for infection imaging. In this article, we compare the roles of anatomic and functional imaging for cardiac device infection and discuss the pros and cons of <sup>18</sup>F-FDG and bacteria-targeting tracers. While anticipating continued investigations for bacteria-specific tracers in the future, we recommend that <sup>18</sup>F-FDG PET/CT, which represents the host–pathogen immune response to infection, be used clinically for identifying cardiovascular device infection.
Aetiology of Abruptio Placentae
Authors: B. M. Hibbard, E. D. Hibbard
Journal: BMJ (1964)

JSHRNALmust forget the bad old imperial system and concentrate on learning drugs prescribed metrically.Iron for the past 30 years has been traditionally prescribed as ferrous sul- phate (or gluconate) 1, 3, 5, or 10 gr.t.i.d.,
Cushing's Syndrome Associated with Carcinoma of the Bronchus in a Patient with Normal Plasma Electrolytes
Authors: M. Friedman, J. R. Mikhail, K. D. Bhoola
Journal: BMJ (1965)

This work was supported by a grant from the Joint Research Board of the Hospital for Sick Children. I am grateful to Mr. D. J. Waterston, Mr. E. Aberdeen, Dr. G. R. Graham, Dr. M. Hawksley, Dr. W. J. Glover, and Dr. R. W. Cope, whose interest and co-operation in the operating-theatre have made this work possible. I am especially grateful to Dr. G. Pampiglione for his invaluable help and encouragement.
177 FOLLOW-UP OF PATIENTS AFTER LIVER TRANSPLANTATION USING DOMINO GRAFTS
Authors: A.P. Barreiros, M. Hoppe-Lotichius, R. Walz, C. Geber, F. Birklein, C. Theis, F. Post, K.-F. Kreitner, P. Galle, G. Otto
Journal: Journal of Hepatology (2012)