tbuckley/cabot-search huggingface dataset:
Postexposure Chemoprophylaxis for Occupational Exposures to the Human Immunodeficiency Virus
Authors: David K. Henderson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Square Wave Electromagnetic Flowmeter for Application to Intact Blood Vessels
Authors: ADAM B. DENISON, MERRILL P. SPENCER, HAROLD D. GREEN
Journal: Circulation Research (1955)

A new type electromagnetic flowmeter which utilizes an alternating square wave magnetic field applied to the unopened blood vessel is described. It attains stability of baseline and sensitivity not possible with older D.C. and A.C. meters and therefore puts measurement of blood flow through the unopened vessel on a practical basis.
Zinc sulphate for viral warts
Authors: S. Gibbs
Journal: British Journal of Dermatology (2003)

Journal Article Zinc sulphate for viral warts Get access S. Gibbs S. Gibbs Department of Dermatology, The Ipswich Hospital, Heath Road, Ipswich, Suffolk IP4 5PD, U.K. E‐mail: sgibbs@fish.co.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 5, 1 May 2003, Pages 1082–1083, https://doi.org/10.1046/j.1365-2133.2003.05362.x Published: 01 May 2003
Oxygen-Saving Effect of a New Cardiotonic Agent, MCI-154, in Diseased Human Hearts
Authors: Masuki Mori, Motoshi Takeuchi, Hideyuki Takaoka, Katsuya Hata, Yoshihiko Hayashi, Hideyuki Yamakawa, Mitsuhiro Yokoyama
Journal: Journal of the American College of Cardiology (1997)
Bladder Hemiation Detected on a Bone Scan
Authors: SERGI VIDAL-SICART, FRANCESCA PONS, MARINA HUGUET, FRANCISCO J. SETOAIN, RAM??N HERRANZ
Journal: Clinical Nuclear Medicine (1995)

Tc-99m MDP bone imaging was performed on a 66-year-old man with known prostatic adenocarcinoma. A large area increased activity in the right inguinal area was observed. Dynamic imaging with Tc-99m pertechnetate showed a photopenic area at the same site, which filled in with the patient standing erect. This demonstrated that the lesion corresponded to a bladder hernia, which the patient had previously refused to have repaired.
The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition
Authors: Natalie A Borg, Lauren K Ely, Travis Beddoe, Whitney A Macdonald, Hugh H Reid, Craig S Clements, Anthony W Purcell, Lars Kjer-Nielsen, John J Miles, Scott R Burrows, James McCluskey, Jamie Rossjohn
Journal: Nature Immunology (2005)
Postextrasystolic alterations in refractoriness of the His-Purkinje system and ventricular myocardium in man.
Authors: M H Lehmann, S Denker, R Mahmud, M Akhtar
Journal: Circulation (1984)

The changes in refractoriness of the His-Purkinje system (HPS) and ventricular myocardium (VM) that are associated with the occurrence of postextrasystolic beats in man are unknown. Accordingly, using a pacing model of the cycle length changes created by a ventricular extrasystole-postextrasystole sequence, we measured retrograde HPS and VM relative and effective refractory periods (RRP and ERP) in 15 patients with the use of ventricular test extrastimuli during preextrasystolic basic control drive (method I) and after programmed extrasystolic (method II) and postextrasystolic (method III) beats. The basic cycle length (same for all three methods) ranged from 500 to 700 msec (mean 613 +/- 74 msec) and the extrasystolic coupling interval (identical for methods II and III) comprised 68 +/- 4% of the basic cycle length. In method III the postextrasystolic pause was programmed to equal the basic cycle length (i.e., noncompensatory) so that method I could serve as control for method III. RRP-HPS decreased from 331 +/- 37 msec in method I to 245 +/- 37 msec or less during the extrasystolic beat (p less than .001). A less dramatic corresponding shortening of ERP-VM and RRP-VM was observed, i.e., from 245 +/- 21 and 264 +/- 23 msec (method I) to 233 +/- 23 and 251 +/- 22 msec (method II), respectively (p less than .001). With the postextrasystolic beat, however, RRP-HPS increased to exceed the control value of method I by 23 +/- 11 msec (p less than .001). This greater-than-expected RP prolongation was also associated with significantly increased retrograde HPS conduction times (in method III vs method I) at both long and short test stimulus coupling intervals.(ABSTRACT TRUNCATED AT 250 WORDS)
The Treatment of Burns: Principles and Practice
Authors: Alfred P. Morgan
Journal: JAMA (1971)

The greater part of this textbook was written by one man (there is one contributed chapter). Consequently, it has the advantages of a single-author book: unity of style and lack of duplication. The book outlines the biologic basis of a system for burn treatment, and describes in detail how to carry it out. The expressed intention is to supply guidance for students and physician who are not burn specialists (ie, those who will treat the majority of burned patients), and it succeeds very well in that aim. Treatment during the acute metabolic phase, acute complications, treatment of the surface, and details of skin grafting are all discussed in detail. There is a chapter devoted to a usually neglected topic, the treatment of minor burns. In all of these the author strikes a nice balance between practical details and physiologic rationale.  The book's shortcomings are also consequences of its having been
Guillain–Barré Syndrome
Authors: Nobuhiro Yuki, Hans-Peter Hartung
Journal: New England Journal of Medicine (2012)

Sera from patients with Guillain-Barré syndrome (GBS) following Campylobacter jejuni infection have autoantibody to GM1 ganglioside in the acute phase of the illness. There is a strong association between GBS and Penner's serotype 19 (PEN 19) of C. jejuni. The terminal structure of the bacterial lipopolysaccharide is identical to the terminal tetrasaccharide of GM1 ganglioside. Anti-GM1 antibody inhibits motoneuron excitability. Molecular mimicry between infectious agents and nerve tissue components may function in the development of GBS.
743 APPLICABILITY OF CURATIVE TREATMENTS IN PATIENTS WITH VERY EARLY HEPATOCELLULAR CARCINOMA (BCLC-0). A GROWING NEED IF FOLLOWING PRACTICE GUIDELINES
Authors: C. Rodríguez de Lope, A. Forner, R. Vilana, J. Rimola, M. Reig, L. Bianchi, M. Sole, J. Fuster, C. Ayuso, C. Bru, J. Bruix
Journal: Journal of Hepatology (2012)
Direct to consumer marketing: Switch to over the counter can become indirect advertising directly to consumers
Authors: Martin Duerden, Tom Walley
Journal: BMJ (2005)

EDITOR—Mansfield et al raise concerns about how advertising directly to consumers may cause inappropriate pressures to use drugs and may exaggerate benefits while minimising risk information.1 They state that the purpose of advertising is to persuade rather than inform. The same edition of the BMJ contained a review of switching prescription drugs to over the counter.2 Can this switch enable …
Estradiol metabolism: an endocrine biomarker for modulation of human mammary carcinogenesis.
Authors: N T Telang, M Katdare, H L Bradlow, M P Osborne
Journal: Environmental Health Perspectives (1997)

The natural estrogen 17beta-estradiol (E2) has a profound influence on proliferation and neoplastic transformation of mammary epithelium. The role of cellular metabolism of E2 in mammary carcinogenesis, however, remains to be elucidated. Explant culture and cell culture models developed from noncancerous human mammary tissue were used to examine modulation of E2 metabolism in response to treatment with prototype rodent mammary carcinogens and the ability of the naturally occurring phytochemical indole-3-carbinol (13C) to influence E2 metabolism and regulate aberrant proliferation. In the two models, treatment with the chemical carcinogens 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene altered the metabolism of E2 as determined from the radiometric (tritium release) and gas chromatography-mass spectrometry (GC-MS) assays. This alteration in E2 metabolism was accompanied by aberrant proliferation and abrogation of apoptosis as determined by the extent of replicative DNA synthesis, S-phase fraction and Sub G0 (apoptotic) peak. Exposure of carcinogen-initiated cultures to 13C resulted in induction of C2-hydroxylation of E2 and of apoptosis and downregulation of hyperproliferation. Determination of altered cellular metabolism of E2 in response to initiators and modulators of carcinogenesis and evaluation of cell cycle related markers for proliferation and apoptosis may provide a mechanism-oriented approach to validate E2 metabolism as an endocrine biomarker for induction and prevention of human mammary carcinogenesis.
For Women Infected With Papillomavirus, Close Watch Counseled
Authors: Chris Anne Raymond
Journal: JAMA (1987)

PHYSICIANS STILL are working out the best approach to dealing with young women infected with human papillomavirus (HPV), alone or in conjunction with intraepithelial neoplasia (please see accompanying article). Donald Goldstein, MD, of Boston's Children's Hospital says, "We treat [the infection site] with trichloroacetic acid, or we just follow the patient at sixmonth intervals." Ralph M. Richart, MD, professor of pathology at Columbia University College of Physicians and Surgeons in New York City, tells clinicians to "follow that patient [with HPV and a normal smear] prospectively, because we [don't yet] know what's going to happen. My bet is that we will find that there's a group... identified as high risk because they're shedding virus who will subsequently develop lesions. What we don't know is what proportion of that [high-risk] population will [do so]." In a presentation at a conference on gynecologic cancer held in Atlanta last year, Richart pointed out
Toxocariasis in Man.
Authors: A. W. Woodruff
Journal: Annals of Internal Medicine (1968)

s1 May 1968Toxocariasis in Man.A. W. Woodruff, F.R.C.P., R. WisemanA. W. Woodruff, F.R.C.P.Search for more papers by this author, R. WisemanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1178_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this study was to try to obtain evidence of the frequency with which man is infected byToxocara canisandT. catiand to delineate the clinical and pathologic features produced by such infection. Although these parasites have long been known to infect dogs and cats, the study of the characteristics of the infection in man is of recent origin. Evidence of infection in man has been sought by use of a standardized skin test and by immunofluorescent techniques. As a prelude to the study the extent of the reservoir of the. infection in dogs and cats... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. W. Woodruff, F.R.C.P.; R. WisemanAffiliations: London, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1178-1178KeywordsSkin infectionsSkin tests ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Priapism and phenothiazines.
Authors: K. Dawson-Butterworth
Journal: BMJ (1970)

Y Chromosomes and Quinacrine Fluorescence Tecique SIR,-The observation that part of the long arm of the Y chromosome fluoresces brightly with quinacrine mustardl" has led Pearson, Bobrow, and Vosa,' using quinacrine hydrochloride, to the discovery that a fluorescent body presumably derived from the Y chromosome is present in the
Postponing or Preventing Deaths?
Authors: James W. Buehler
Journal: JAMA (1985)

Trends in survival were examined for infants in five birth-weight groups (500 to 999 g, 1,000 to 1,499 g, 1,500 to 1,999 g, 2,000 to 2,499 g, and ≥2,500 g). The study population consisted of infants born in Georgia from 1974 through 1981. Survival to the first birthday increased for all birthweight groups. Improvements in postneonatal survival occurred concurrently with improvements in neonatal survival, except for infants with birth weights of 500 to 999 g. Between 1974-1975 and 1980-1981, the proportion of deaths that were attributed to perinatal conditions but occurred during the postneonatal period increased from 1.1% to 4.7%. These observations suggest that advances in perinatal care have led to postponement rather than prevention of a few infant deaths, although overall many more deaths were prevented. For infants with birth weights of less than 1,500 g, lower mortality among those admitted to newborn intensive care units was the major contributor to improved survival. Our findings indicate that both neonatal and postneonatal mortality should be examined in evaluating the effects of perinatal care. (<i>JAMA</i>1985;253:3564-3567)
THE IMPACT OF SYSTOLIC DYSFUNCTION ON PROGNOSIS OF GENOTYPED HYPERTROPHIC CARDIOMYOPATHY
Authors: Noboru Fujino, Tetsuo Konno, Akihiko Hodatsu, Kenshi Hayashi, Katsuharu Uchiyama, Takashi Fujita, Toyonobu Tsuda, Hidekazu Ino, Masakazu Yamagishi
Journal: Journal of the American College of Cardiology (2011)
OXYTOCIN; A PRIMING REAGENT TO COMMIT UCB-MSCS FOR CARDIAC REPAIR -FUNCTION STUDY AND PHASE RETARDATION IMAGING TECHNIQUE OF OXYTOCIN-TREATED UCB-MSC
Authors: Youngkeun Ahn, Yong Sook Kim, Ae Shin Jo, Mun Hwa Hong, Jin Sook Kwon, Sang Mo Shin, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Journal: Journal of the American College of Cardiology (2010)
Erosive pustular dermatosis of the leg associated with compression bandaging and fungal infection
Authors: G. Dawn, M. Loney, M. Zamiri, F. Shaffrali, M. Urcelay, M. Patel, S.R. Howatson, W.S. Douglas
Journal: British Journal of Dermatology (2003)

Erosive pustular dermatosis of the leg (EPDL) has been described in association with venous insufficiency and atrophy of the skin of the lower leg. Like erosive pustular dermatosis of the scalp, this disease has also been reported to be a non-infective condition.To investigate the clinicopathological features and, where possible, the aetiology of clinical EPDL.We identified a group of patients undergoing continuous compression bandaging for venous dermatitis of the legs and/or predominantly venous leg ulceration with clinical features described in patients with EPDL. They were investigated by skin biopsy, patch testing and microbiological tests for the presence of bacteria and fungi.Twenty-four of 400 (6%) patients were noted to have pustules on the leg(s). There was laboratory evidence of fungal infection in 13 of 24 patients (54%), with complete and sustained resolution of pustules after antifungal treatment. Pustulation in the other 11 patients (46%) was unresponsive to antibiotics for confirmed bacterial infection; some improvement was seen with potent topical corticosteroids but full clearance was achieved only after a switch from continuous four-layer compression bandaging to the use of intermittent long stretch compression.EPDL is a fairly common clinical picture seen in patients undergoing continuous compression bandaging. It may be produced by opportunistic, particularly fungal, infection. In almost half an infective aetiology cannot be demonstrated and a pyoderma gangrenosum-like process may be implicated.
Mechanical ventilation may damage organs other than the lungs
Authors: M K Johnson
Journal: Thorax (2003)

▴ Imai Y, Parodo J, Kajiwaka O, et al . Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA2003;289:2104–12 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] In this laboratory study, acute respiratory distress syndrome was induced by acid aspiration in 24 rabbits which were then randomised to injurious (tidal volume 15–17 ml/kg, PEEP 0–3 cm H2O) or non-injurious ventilation (tidal volume 5–7 ml/kg, PEEP 9–12 cm … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.issn%253D0002-9955%26rft.aulast%253DImai%26rft.auinit1%253DY.%26rft.volume%253D289%26rft.issue%253D16%26rft.spage%253D2104%26rft.epage%253D2112%26rft.atitle%253DInjurious%2BMechanical%2BVentilation%2Band%2BEnd-Organ%2BEpithelial%2BCell%2BApoptosis%2Band%2BOrgan%2BDysfunction%2Bin%2Ban%2BExperimental%2BModel%2Bof%2BAcute%2BRespiratory%2BDistress%2BSyndrome%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.289.16.2104%26rft_id%253Dinfo%253Apmid%252F12709468%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.289.16.2104&link_type=DOI [3]: /lookup/external-ref?access_num=12709468&link_type=MED&atom=%2Fthoraxjnl%2F58%2F7%2F612.atom [4]: /lookup/external-ref?access_num=000182374300026&link_type=ISI
Münchhausen Syndromes and Factitious Diseases
Authors: Reinhard Plassmann
Journal: Psychotherapy and Psychosomatics (1994)

Review Articles| February 18 2010 Münchhausen Syndromes and Factitious Diseases Subject Area: Psychiatry and Psychology Reinhard Plassmann Reinhard Plassmann Burg-Klinik, Stadtlengsfeld, Deutschland Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1994) 62 (1-2): 7–26. https://doi.org/10.1159/000288899 Article history Published Online: February 18 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Reinhard Plassmann; Münchhausen Syndromes and Factitious Diseases. Psychother Psychosom 31 December 1994; 62 (1-2): 7–26. https://doi.org/10.1159/000288899 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1994Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Protein arginine methyltransferase 1 regulates hepatic glucose production in a FoxO1-dependent manner
Authors: Dahee Choi, Kyoung-Jin Oh, Hye-Sook Han, Young-Sil Yoon, Chang-Yun Jung, Seong-Tae Kim, Seung-Hoi Koo
Journal: Hepatology (2012)

Postprandial insulin plays a critical role in suppressing hepatic glucose production to maintain euglycemia in mammals. Insulin-dependent activation of protein kinase B (Akt) regulates this process, in part, by inhibiting FoxO1-dependent hepatic gluconeogenesis by direct phosphorylation and subsequent cytoplasmic exclusion. Previously, it was demonstrated that protein arginine methyltransferase 1 (PRMT1)-dependent arginine modification of FoxO1 interferes with Akt-dependent phosphorylation, both in cancer cells and in the Caenorhabditis elegans model, suggesting that this additional modification of FoxO1 might be critical in its transcriptional activity. In this study, we attempted to directly test the effect of arginine methylation of FoxO1 on hepatic glucose metabolism. The ectopic expression of PRMT1 enhanced messenger RNA levels of FoxO1 target genes in gluconeogenesis, resulting in increased glucose production from primary hepatocytes. Phosphorylation of FoxO1 at serine 253 was reduced with PRMT1 expression, without affecting the serine 473 phosphorylation of Akt. Conversely, knockdown of PRMT1 promoted an inhibition of FoxO1 activity and hepatic gluconeogenesis by enhancing the phosphorylation of FoxO1. In addition, genetic haploinsufficiency of Prmt1 reduced hepatic gluconeogenesis and blood-glucose levels in mouse models, underscoring the importance of this factor in hepatic glucose metabolism in vivo. Finally, we were able to observe an amelioration of the hyperglycemic phenotype of db/db mice with PRMT1 knockdown, showing a potential importance of this protein as a therapeutic target for the treatment of diabetes.Our data strongly suggest that the PRMT1-dependent regulation of FoxO1 is critical in hepatic glucose metabolism in vivo.
Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells
Authors: G.M. MURPHY, P.G. NORRIS, A.R. YOUNG, M.F. CORBETT, J.L.M. HAWK
Journal: British Journal of Dermatology (1993)

We have examined the effects of low‐dose monochromatic UVB irradiation (295±5 nm), biologically equivalent to that generally incident on the skin during a 12‐session sun‐bed course, on the expression of the CDla epidermal Langerhans cell surface marker in human skin in vivo. In five subjects, 1.5 minimal erythema doses (MEDs) at 295 nm depleted its expression by 50%. In five further subjects, a single 1.5 MED dose, 1.5 MEDs in 10 equal fractions on alternate days, and a single 1.5 MED dose at one‐tenth the previously used irradiance, delivered to separate sites, also led to variable but significant depletion of CD la expression of around‐30–50%. Thus, low‐dose UVB irradiation, whether received rapidly or slowly, appears significantly and approximately equally to deplete human epidermal Langerhans cell numbers as measured by CDla expression.