tbuckley/cabot-search huggingface dataset:
Diagnosis of Metabolic Acid–Base Disturbances in Critically Ill Patients
Authors: VLADIMIR FENCL, ANTONÍN JABOR, ANTONÍN KAZDA, JAMES FIGGE
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

We compare two commonly used diagnostic approaches, one relying on plasma bicarbonate concentration and “anion gap,” the other on “base excess,” with a third method based on physicochemical principles, for their value in detecting complex metabolic acid–base disturbances. We analyzed arterial blood samples from 152 patients and nine normal subjects for pH, Pco 2, and concentrations of plasma electrolytes and proteins. Ninety-six percent of the patients had serum albumin concentration ⩽ 3 SD below the mean of the control subjects. In about one-sixth of the patients, base excess and plasma bicarbonate were normal. In a great majority of these apparently normal samples, the third method detected simultaneous presence of acidifying and alkalinizing disturbances, many of them grave. The almost ubiquitous hypoalbuminemia confounded the interpretation of acid–base data when the customary approaches were applied. Base excess missed serious acid–base abnormalities in about one-sixth of the patients; this method fails when the plasma concentrations of the nonbicarbonate buffers (mainly albumin) are abnormal. Anion gap detected a hidden “gap acidosis” in only 31% of those samples with normal plasma bicarbonate in which such acidosis was diagnosed by the third method; when adjusted for hypoalbuminemia, it reliably detected the hidden abnormal anions. The proposed third method identifies and quantifies individual components of complex acid–base abnormalities and provides insights in their pathogenesis.
Conditioning and Hyperalgesia in Newborns Exposed to Repeated Heel Lances
Authors: Anna Taddio
Journal: JAMA (2002)

ContextHospitalized infants undergo repeated invasive procedures. It is unknown whether cumulative experiences with pain lead to anticipatory pain behaviors and hyperalgesia.ObjectivesTo determine whether newborns who are born to mothers with diabetes and undergo repeated pain learn to anticipate pain and exhibit more pain during a painful procedure than normal infants.Design, Setting, and ParticipantsProspective cohort study of 21 full-term newborns born to mothers with diabetes and 21 born to mothers with uneventful pregnancies, at a university teaching hospital between August 1999 and October 2000. Infants of diabetic mothers underwent repeated heel lances in the first 24 to 36 hours of life for monitoring of blood glucose concentrations. Pain responses of all infants undergoing a venipuncture on the dorsum of the hand to obtain blood for the newborn screening test after the first day of life were compared. In addition, from September through November 2001, 12 infants of diabetic mothers and 12 normal infants were compared for pain reactions to intramuscular vitamin K injection after birth.Main Outcome MeasuresPercentages of time observed grimacing and crying and visual analog scale (VAS) scores.ResultsRaters were blinded to exposure group. Median baseline scores for grimacing, crying time, and VAS did not differ significantly between groups (P = .27, P = .32, and P = .32, respectively). Median scores (interquartile range) for grimacing during skin cleansing were higher in infants of diabetic mothers (22.2% [77.5%] vs 0% [15%]; P = .03). The VAS scores for both groups were zero, but the distribution of the scores was significantly different (86% of normal infants vs 52% of infants of diabetic mothers had scores of zero) (P = .04). During venipuncture, infants of diabetic mothers had higher median scores for grimacing (81.7% [32.5%] vs 40% [73.4%]; P = .01), VAS (69% [27.5%] vs 5% [60.5%]; P = .002), and crying (40.2% [77%] vs 0% [54.8%]; P = .03) compared with normal infants. There were no differences between groups on any pain measure in response to intramuscular injection.ConclusionsNewborns who had diabetic mothers and were exposed to repeated heel lances in the first 24 to 36 hours of life learned to anticipate pain and exhibited more intense pain responses during venipuncture than normal infants.
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
Authors: Joachim Lupberger, Mirjam B Zeisel, Fei Xiao, Christine Thumann, Isabel Fofana, Laetitia Zona, Christopher Davis, Christopher J Mee, Marine Turek, Sebastian Gorke, Cathy Royer, Benoit Fischer, Muhammad N Zahid, Dimitri Lavillette, Judith Fresquet, François-Loïc Cosset, S Michael Rothenberg, Thomas Pietschmann, Arvind H Patel, Patrick Pessaux, Michel Doffoël, Wolfgang Raffelsberger, Olivier Poch, Jane A McKeating, Laurent Brino, Thomas F Baumert
Journal: Nature Medicine (2011)
Altered Zonal Expression of the Cd26 Antigen (Dipeptidyl Peptidase Iv) in Human Cirrhotic Liver
Authors: Yorio Matsumoto, Alex G. Bishop, Geoffrey William McCaughan
Journal: Hepatology (1992)

Dipeptidyl peptidase IV is a cell surface ectopeptidase with widespread tissue distribution. Recently it was shown to display extracellular matrix—binding properties; therefore its role in cirrhosis is of interest. The aim of this study was to use monoclonal antibodies directed against the human CD26 antigen (which has been shown to be dipeptidyl peptidase IV) to study the distribution of this molecule in normal human and cirrhotic liver. Identical staining was obtained with the three monoclonal antibodies (TaI, 1F7 and TS145) and enzyme histochemistry. In normal liver (n = 11) intense staining of hepatic acinar zones 2 and 3 was present, but little staining was seen in zone I. Hepatocyte staining was confined to the bile canalicular domain. In cirrhotic livers (n = 23) obtained at transplantation, staining of regenerating nodules without a zonal pattern was present. In addition, we saw staining of the lymphoid cell infiltrate and proliferating bile ductules. In a minority of cirrhotic biopsy specimens (four) staining of the basolateral hepatocyte domain in regenerating nodules was seen. Biopsy specimens from hepatic allografts (n = 28) were used as disease controls. These samples all showed preferential staining of zones 2 and 3, similar to that in normal biopsy speclimens. Eleven of these samples showed staining of the basolateral and bile canalicular domains. In conclusion, the normal acinar distribution of dipeptidyl peptidase IV (zones 2 and 3) is lost in cirrhotic nodules. Furthermore, the altered membrane distribution of this molecule in cirrhosis and allograft rejection may allow increased hepatocyte extracellular matrix interactions during organ remodeling. (Hepatology 1992;15:1048-1053.
Undertreatment of rhinitis symptoms in Europe: findings from a cross‐sectional questionnaire survey
Authors: M. Maurer, T. Zuberbier
Journal: Allergy (2007)

Background: Allergic rhinitis is a frequent disease affecting one in five Europeans with a significant impact on patient quality of life, health‐care costs, and economic productivity. Although effective treatments exist, the disease often remains undiagnosed and not correctly treated, despite clear diagnostic and therapeutic guidelines from WHO, EAACI (European Academy of Allergology and Clinical Immunology), and GA 2 LEN (Global Allergy and Asthma European Network). This study elucidates the reasons for this discrepancy from the patients’ point of view. Methods: An internet and telephone survey was conducted with 2966 randomly selected adults with allergies from the general population in the five major EU countries: UK, France, Germany, Italy, and Spain. Results: The main reason that the majority of respondents first visited a medical professional for their rhinitis symptoms was because these symptoms became intolerable. The respondents had not seen a medical professional in the past year for their rhinitis symptoms in 52.6% of the cases, and 30.2% of the respondents preferred nonprescription medication because it did not require visiting a doctor. ‘Nontreaters’ and ‘homeopathic treaters’ together made up 26.2% of the respondents, and 40.2% of them gave the cost of medication as a reason they do not use allergy medications. Conclusions: Allergic rhinitis remains widely undertreated in Europe with avoidable socioeconomic consequences. Effective treatment exists, but patients wait too long to seek medical advice, and health providers neglect to actively screen early for allergies.
Hepatic Vitamin A Depletion in Alcoholic Liver Injury
Authors: Maria Anna Leo, Charles S. Lieber
Journal: New England Journal of Medicine (1982)

SYMPTOMS of vitamin A deficiency, such as night blindness and hypogonadism, have been described in alcoholics,1 , 2 but the relation between alcoholism, serum vitamin A, and hepatic vitamin A is not known.Previous studies of hepatic vitamin A levels in various disease states involved only autopsy material, did not include biopsy data, and did not specify whether the subjects studied were alcoholic.3 4 5 There are some reports on patients with alcoholic cirrhosis who had evidence of a low circulating level of vitamin A,2 , 6 7 8 but the actual hepatic vitamin A concentrations of these subjects have not been described. Therefore, we undertook a study . . .
Suicide by Physicians-Reply
Authors: Grover M. Hutchins
Journal: JAMA (1984)

<h3>In Reply.—</h3> Dr Anteski's letter shows the problem of statements taken out of context. It would seem reasonable to assume that communications written by physicians, published in medical journals, and aimed at an audience of physicians do not need a restatement of the Hippocratic oath. In other words, our readers may assume that we have the same concern for the welfare of the individual physician as patient or sufferer as for any other person. Despite efforts by the judicial process, epidemiologists, and philosophers, it is difficult if not impossible to assign a monetary value to an individual life. It is evident, however, that physicians as a group, like the members of other professions, represent an enormous financial investment and have an enormous actual and potential economic influence. Suicide as a subject of investigation is of importance, and it has additional importance to society when loss of members of the group
Occult Celiac Disease as a Cause of Iron Deficiency Anemia
Authors: Zachary M. Kilpatrick
Journal: JAMA (1969)

Occult celiac disease was the cause of chronic iron deficiency anemia in two women who did not have clinically apparent malabsorption. There had been no response to oral administration of iron and neither had had abnormal blood loss. Iron deficiency anemia that is refractory to oral iron therapy may be due to celiac disease. Tests of intestinal absorption and biopsy of the small bowel are indicated.
TCT-150 Factors Associated With Premature Clopidogrel Discontinuation After Drug-Eluting Stent Implantation
Authors: Michael A. Gaglia, Itsik Ben Dor, Fang Chen, Augusto Pichard, Lowell F. Satler, William O. Suddath, Rebecca Torguson, Ron Waksman
Journal: Journal of the American College of Cardiology (2013)
The warm ischaemic time of the canine heart
Authors: P. A. Cullum, J. S. Bailey, A. C. Branfoot, M. J. Pemberton, V. J. Redding, J. R. Rees
Journal: Cardiovascular Research (1970)

Journal Article The warm ischaemic time of the canine heart Get access P. A. Cullum, P. A. Cullum 1 From the Department of Thoracic Surgery and the Department of Clinical Measurement, Westminster Hospital, London 1 Present address: Department of Surgery, King's College Hospital Medical School, Denmark Hill, London S.E.5. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. S. Bailey, J. S. Bailey From the Department of Thoracic Surgery and the Department of Clinical Measurement, Westminster Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar A. C. Branfoot, A. C. Branfoot From the Department of Thoracic Surgery and the Department of Clinical Measurement, Westminster Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. Pemberton, M. J. Pemberton From the Department of Thoracic Surgery and the Department of Clinical Measurement, Westminster Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar V. J. Redding, V. J. Redding From the Department of Thoracic Surgery and the Department of Clinical Measurement, Westminster Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Russell Rees J. Russell Rees From the Department of Thoracic Surgery and the Department of Clinical Measurement, Westminster Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 1, January 1970, Pages 67–72, https://doi.org/10.1093/cvr/4.1.67 Published: 01 January 1970 Article history Accepted: 17 February 1969 Published: 01 January 1970
'Urban Cowboy' Myoglobinuria
Authors: A. Tyler Upham
Journal: JAMA (1981)

To the Editor.—  Exertional rhabdomyolysis and myoglobinuria have been associated with various types of physical activity. Myoglobinuria has been reported in wrestlers, jack-hammer users, football players, marathon runners, and military recruits. 1-5 It most often occurs in poorly conditioned persons, and when associated with dehydration, acidosis, or hypotension, may lead to acute renal failure.  We recently saw a patient who had severe rhabdomyolysis and myoglobinuria after riding a mechanical bucking bull. Riding such a contraption has become an increasingly popular activity in country-western nightclubs as depicted in a recent motion picture. We therefore labeled our patient's condition urban cowboy myoglobinuria.  Report of a Case.—  A 30-year-old man in excellent health spent an evening at a country-western nightclub drinking beer, listening to music, and riding a mechanical bull. Because of some previous rodeo experience, he rode the bull on the professional setting. The bull was ridden three times for a total
The Histopathologic and Clinical Spectrum of Granulomatous and Ulcerative Colitis.
Authors: Donald J. Glotzer
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971The Histopathologic and Clinical Spectrum of Granulomatous and Ulcerative Colitis.Donald J. Glotzer, M.D., Louis Zetzel, M.D., Richard C. Gardner, M.D., H. Richard Hinrichs, M.D., Harvey Goldman, M.D.Donald J. Glotzer, M.D.Search for more papers by this author, Louis Zetzel, M.D.Search for more papers by this author, Richard C. Gardner, M.D.Search for more papers by this author, H. Richard Hinrichs, M.D.Search for more papers by this author, Harvey Goldman, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-834_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 95 patients with resections for colonic inflammation the histologic features were assessed blindly to determine whether these were distinctive for ulcerative or granulomatous colitis and whether they predicted the clinical behavior. There were statistically highly significant relationships between the following: sinus tracts (fissures) with noncaseating granulomas; segmental disease with sinus tracts and granulomas; clinical criteria of granulomatous colitis with sinus tracts and granulomas; and clinical criteria of ulcerative colitis with absence of sinus tracts and granulomas. Granulomatous colitis could be best diagnosed on the basis of combined criteria rather than by purely clinical or microscopic criteria. Considering other features... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 834-834KeywordsBehaviorColitisGranulomasInflammationUlcerative colitis Issue Published: 1 May 1971 PDF DownloadLoading ...
Public health activism: lessons from history?
Authors: Virginia Berridge
Journal: BMJ (2007)

<b>1601</b> <h3><b>Objectives:</b></h3> The aim of our investigation was to evaluate <sup>18</sup>F-FDG accumulation in uninfected aortic endovascular grafts, and to track the changes in <sup>18</sup>F-FDG uptake over time. <h3><b>Methods:</b></h3> The departmental database was searched to identify pts with aortic endovascular grafts who underwent serial <sup>18</sup>F-FDG PET/CT imaging for oncologic indications. All pts were more than 6 months post aortic graft implantation and were asymptomatic with respect to the graft. The time interval of all scans for all pts was 1.5±1.2 yrs (range = 84 days - 5.4 yrs). Seventy-three <sup>18</sup>F-FDG PET/CT scans performed on 22 pts (4 female; 18 male; age: 74±10 yrs; range: 63 - 90 yrs) were reviewed retrospectively by a single nuclear physician. SUV<sub>max</sub> values were measured in the ascending thoracic aorta and were considered to represent <sup>18</sup>F-FDG background (B). SUV<sub>max</sub> values also were measured at 3 locations along the graft (G). Mean aortic G SUV<sub>max</sub> values and G/B ratios were calculated. Differences in G /B ratio per pt were determined by the unpaired t-test. Significance of changes over time were determined by comparing B/G ratios at later time points compared to the initial time point, per pt. <h3><b>Results:</b></h3> There were a total of 73 <sup>18</sup>F-FDG PET/CT scans performed on the 22 pts: 10 pts had 2 scans, 5 pts had 3, 2 pts had 4, 2 pts had 5, 2 pts had 6 and 1 pt had 8 scans. Among all 22 pts at all time points, G ranged from 0.7-3.0 and B ranged from 1.0-3.2; G and B were statistically similar (1.80±0.44 versus 1.81±0.33, p = 0.85). Per pt, G was significantly lower than B in 10 scans of 5 pts (1.49±0.22 versus 1.82±0.39, p = 0.002), and G was significantly higher than B in 7 scans of 5 pts (2.42±0.27 versus 1.89±0.27, p = 0.009). Over time, statistically significant differences in G were found in 16% (12/73) of scans. Ten of the 22 pts (45%) had statistically significant differences between G and B values. G increased in 5/10 pts, starting with a mean SUV<sub>max</sub> 0.77±0.89, which increased to SUV<sub>max</sub> 1.99±0.50 (p = 0.01) over a mean time of 833± 644 days. G decreased in 5/10 pts, starting with a mean SUV<sub>max</sub> 1.95±0.50, which decreased to SUV<sub>max</sub> 1.54±0.56 (p = 0.01) over a mean time difference of 513±474 days. However, much of this apparent change was attributable to overall changes in <sup>18</sup>F-FDG uptake per pt, insofar as G/B ratio changed only marginally over time and in only 3 pts, decreasing from 1.01±0.21 to 0.70±0.05 (p = 0.07). For all scans of all pts, G/B ratio = 1.00±0.22 (range: 0.57-1.84). Consequently, in our series of pts, the upper limit of G/B ratio for uninfected aortic endovascular grafts was 1.43. <b>Conclusion:</b> On a scan-by-scan basis, mean aortic endovascular graft uptake can appear to be higher or lower than background uptake. But intraindividual <sup>18</sup>F-FDG G/B ratios for these grafts is relative stable over time.
Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel
Authors: Takahisa Masaki, Ramesh Rathi, Gaylen Zentner, John K. Leypoldt, Syed F. Mohammad, Gregory L. Burns, Li Li, Sergey Zhuplatov, Thanit Chirananthavat, Seung-Jung Kim, Steven Kern, John Holman, Sung Wan Kim, Alfred K. Cheung
Journal: Kidney International (2004)
From Biomedical to Biopsychosocial
Authors: George L. Engel
Journal: Psychotherapy and Psychosomatics (1997)

Editorials| February 18 2010 From Biomedical to Biopsychosocial: 1. Being Scientific in the Human Domain Subject Area: Psychiatry and Psychology George L. Engel George L. Engel Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester. N.Y., USA Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1997) 66 (2): 57–62. https://doi.org/10.1159/000289109 Article history Published Online: February 18 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation George L. Engel; From Biomedical to Biopsychosocial: 1. Being Scientific in the Human Domain. Psychother Psychosom 1 February 1997; 66 (2): 57–62. https://doi.org/10.1159/000289109 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1997Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
CD27-CD70 interactions in the pathogenesis of Waldenström macroglobulinemia
Authors: Allen W. Ho, Evdoxia Hatjiharissi, Bryan T. Ciccarelli, Andrew R. Branagan, Zachary R. Hunter, Xavier Leleu, Olivier Tournilhac, Lian Xu, Kelly O'Connor, Robert J. Manning, Daniel Ditzel Santos, Mariana Chemaly, Christopher J. Patterson, Jacob D. Soumerai, Nikhil C. Munshi, Julie A. McEarchern, Che-Leung Law, Iqbal S. Grewal, Steven P. Treon
Journal: Blood (2008)
Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice.
Authors: J O Jansson, S Ekberg, S B Hoath, W G Beamer, L A Frohman
Journal: Journal of Clinical Investigation (1988)

The effect of growth hormone (GH) on binding of epidermal growth factor (EGF) to liver membrane preparations was investigated in hypophysectomized mice and partially GH-deficient, genetic mutant "little" (lit/lit) mice. The EGF binding of normal male mice and testosterone-treated females was higher than in normal females. Due to diminished receptor concentration, hepatic EGF binding was decreased in male and female lit/lit mice to a level that was unaffected by gender or androgen treatment. GH replacement therapy by intermittent injections and continuous infusion restored the EGF binding of hypophysectomized mice to normal male and female levels, respectively, suggesting a role for the more pulsatile GH secretion in normal males. In lit/lit mice, however, both continuous and intermittent GH resulted in EGF binding levels comparable to those in normal females. In normal males continuous GH suppressed EGF binding. In conclusion, endogenous GH secretion induces EGF receptors in mice and this effect may be modulated by sex differences in GH secretion.