Rheumatoid Factor in Serum and Joint Fluid
Authors: JOHN H. BLAND
Journal: Annals of Internal Medicine (1963)

Article1 May 1963Rheumatoid Factor in Serum and Joint FluidJOHN H. BLAND, M.D., F.A.C.P., LESLIE CLARK, B.S., M.S.JOHN H. BLAND, M.D., F.A.C.P.Search for more papers by this author, LESLIE CLARK, B.S., M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-829 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost of the information on the macroglobulin, rheumatoid factor, has been derived from studies on sera. Relatively few data are available on the presence of rheumatoid factor in connective tissue extracts or body fluids other than serum. Rheumatoid factors have most of the properties of antibodies; proteins of antibody type are very probably synthesized by cells of the lymphocyte-plasma cell series. Plasma cells only rarely are found circulating in the blood, and in the mammal they are connective tissue cells located in extravascular extracellular space; plasma cells are ubiquitous, and like lymphocytes from which they arise they are found in...References1. LAMONT-HAVERS RW, Editor: Serological Reactions of Rheumatoid Arthritis. Summary of First Conference, 1957. Arthritis Rheum. Issued by the Medical and Scientific Committee, New York. Google Scholar2. MELLORSHEIMERCORCOSKORNGOLD RCRJL: Cellular origin of rheumatoid factor. J. Exp. Med. 110: 875, 1959. CrossrefMedlineGoogle Scholar3. ROBECCHIDANEO HV: Research on the behavior, nature and meaning of the rheumatoid factor. Acta Rheum. Scand. 5: 245, 1959. CrossrefMedlineGoogle Scholar4. KREHLBOISVERTDEFORESTMUCCI WAPLGKMB: Rheumatoid factor in serum and synovial fluid. Yale J. Biol. Med. 30: 30, 1957-58. MedlineGoogle Scholar5. GUARIGLIABERKOWITZSTEINBROCKER ESO: Latex agglutination in serum and synovial fluid. Abstract Proc. American Rheumatism Association, June 9-11, 1960. Arthritis Rheum. 3: 447, 1960. Google Scholar6. BALL J: Rheumatoid serum factor in extracts of skin and other tissues, Heberden Society Proceedings, Ann. Rheum. Dis. 19: 381, 1960. Google Scholar7. BALL J: Observations of rheumatoid serum factor in skin and other tissues. Ann. Rheum. Dis. 272: 21, 1962. Google Scholar8. SINGERPLOTZ JMLM: Latex fixation test. I. Application to serologic diagnosis of rheumatoid arthritis. Amer. J. Med. 21: 888, 1956. CrossrefMedlineGoogle Scholar9. KELLGRENBALL JHJ: Clinical significance of the rheumatoid serum factor. Brit. Med. J. 1: 523, 1959. CrossrefMedlineGoogle Scholar10. MACINTOSH FS: Discussion of paper, "Location of Histamine in the Body," by J. F. Riley; Ciba Symposium on Histamine, J. and A. Churchill, Ltd., London, 1956, p. 407. Google Scholar11. DRINKER CK: Extravascular protein and the lymphatic system. Ann. NY Acad. Sci. 46: 807, 1946. CrossrefGoogle Scholar12. CHAMBERSZWEIFACH RBW: Intercellular cement and capillary permeability. Physiol. Rev. 27: 436, 1947. CrossrefMedlineGoogle Scholar13. PAPPENHEIMER JR: Passage of molecules through capillary walls. Physiol. Rev. 33: 387, 1953. CrossrefMedlineGoogle Scholar14. FORKERCHAIKOFFREINHARDT LLILJ: Circulation of plasma proteins: their transport by lymph. J. Biol. Chem. 197: 625, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Burlington, VermontFrom the Rheumatism Research Unit, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont.This work was supported by training grant 2A-5087, National Institute of Arthritis and Metabolic Diseases, United States Public Health Service.Requests for reprints should be addressed to John H. Bland, M.D., Department of Medicine, Medical Alumni Building, The University of Vermont, Burlington, Vermont. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAutoantibodies in rheumatoid arthritisOn the Presence of Rheumatoid Factor in Joints Before and After SynovectomyOn the Presence of Rheumatoid Factor in Joints before and after SynovectomyPleural Effusion in Rheumatoid ArthritisRHEUMATOID FACTORS AND THE ETIOLOGY OF RHEUMATOID ARTHRITIS*Studies on the Pathogenesis of Rheumatoid Joint Inflammation I. The "R.A. Cell" and a Working HypothesisJOSEPH LEE HOLLANDER, M.D., F.A.C.P., DANIEL J. MCCARTY JR., M.D., F.A.C.P., GONZALO ASTORGA, M.D., EDUARDO CASTRO-MURILLO, M.D.Surgical Treatment of Rheumatoid Arthritis 1 May 1963Volume 58, Issue 5Page: 829-836KeywordsAntibodiesArthritisCellsConnective tissueLatexLymphocytesMedical servicesMetabolic disordersPlasma cellsProteins Issue Published: 1 May 1963 PDF DownloadLoading ...