tbuckley/cabot-search huggingface dataset:
Anaphylaxis and Cerebral Hyadatidic Disease
Authors: Maria Dolores Alonso Diaz de Durana
Journal: Annals of Internal Medicine (1997)

Letters1 May 1997Anaphylaxis and Cerebral Hyadatidic DiseaseMaria Dolores Alonso Diaz de Durana, MD, A. Lopez, MD, and J. Fraj, MDMaria Dolores Alonso Diaz de Durana, MDHospital Obispo Polanco, 44002 Tervel, SpainSearch for more papers by this author, A. Lopez, MDHospital Obispo Polanco, 44002 Tervel, SpainSearch for more papers by this author, and J. Fraj, MDHospital Obispo Polanco, 44002 Tervel, SpainSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 60-year-old male farmer and cattle owner presented to the emergency department with generalized urticaria and angioedema, syncope, and severe hypotension. His leukocyte count revealed 430 eosinophils/mm3, results of serologic testing with passive hemagglutination were positive for hydatidosis, total IgE concentration was normal (60 IU/mL), and results of a radioallergosorbent assay for Echinococcus (Pharmacia Diagnostics, Uppsala, Sweden) were positive (class 3). Results of chest radiography, abdominal ultrasonography, and abdominal computed tomography were unremarkable. Systemic anaphylaxis, probably secondary to the rupture of a hidden hydatidic cyst, was diagnosed. During follow-up in the allergy department, hydatid serologic titers progressively ...References1. Barros JL. Hydatidic disease of the liver. Am J Surg. 1978; 135:597-600. Google Scholar2. Nonviral infections of the nervous system. The major categories of neurologic disease. In: Adams RD, Victor M. Principles of Neurology. 5th ed. New York: McGraw-Hill; 1993:636. Google Scholar3. Arboix A. Neurohidatidosis. Neuroinfecciones por otros agentes infecciosos. In: Ed ELA SL Tratado de Neurologia. A Codina Puiggros. 1994:199-204. Google Scholar4. Ersahin Y, Mutluer S, Guzelbag E. Intracranial hydatid cysts in children. Neurosurgery. 1993; 33:219-24. Google Scholar5. Subhash C, Sharman, Ray RC. Primary hydatid cyst of the brain in an adult: report of a case. Neurosurgery. 1988; 23:374-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Maria Dolores Alonso Diaz de Durana, MD; A. Lopez, MD; J. Fraj, MDAffiliations: Hospital Obispo Polanco, 44002 Tervel, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimary Hydatid Cyst of the Brain in a Child: A Case ReportComplications of Cerebral HydatidosisPrinciples of ParasitismInadvertent Rupture of an Echinococcal Cyst: Case Report and Review of Literature 1 May 1997Volume 126, Issue 9Page: 745KeywordsAnaphylaxisComputed axial tomographyEchinococcosisShockSurgerySyncopeTendonsThoraxUltrasound imagingUrticaria ePublished: 15 August 2000 Issue Published: 1 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
T_3 Euthyroidism in Thyroid Carcinoma
Authors: ROBERT L. PEAKE
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 October 1978T3 Euthyroidism in Thyroid CarcinomaROBERT L. PEAKE, M.D.ROBERT L. PEAKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-578_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the article "T3Euthyroidism in Follicular Thyroid Carcinoma" by Kabadi and Albin (Ann Intern Med88:359-360, 1978) there is mention in the case history that "the patient was maintained on 75 µg of Cytomel®/day". No dates are given for the administration of triiodothyronine, but it must be clarified that the patient was not receiving this drug when the normal T3levels were obtained later in the course of her disease.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The University of Galveston Medical Branch Galveston, TX 77550 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1978Volume 89, Issue 4Page: 578-578KeywordsDrug administrationDrugsThyroid carcinomaTriiodothyronine Issue Published: 1 October 1978 PDF DownloadLoading ...
Effect of Atropine on Vagal Release of Gastrin and Pancreatic Polypeptide
Authors: Mark Feldman, Charles T. Richardson, Ian L. Taylor, John H. Walsh
Journal: Journal of Clinical Investigation (1979)

We studied the effect of several doses of atropine on the serum gastrin and pancreatic polypeptide responses to vagal stimulation in healthy human subjects. Vagal stimulation was induced by sham feeding. To eliminate the effect of gastric acidity on gastrin release, gastric pH was held constant (pH 5) and acid secretion was measured by intragastric titration. Although a small dose of atropine (2.3 μg/kg) significantly inhibited the acid secretory response and completely abolished the pancreatic polypeptide response to sham feeding, this dose of atropine significantly enhanced the gastrin response. Higher atropine doses (7.0 and 21.0 μg/kg) had effects on gastrin and pancreatic polypeptide release which were similar to the 2.3-μg/kg dose. Atropine (0.78 and 2.3 μg/kg) without sham feeding significantly inhibited basal acid secretion and also led to significant increases in serum gastrin above basal levels. The gastrin response to sham feeding with 2.3 μg/kg atropine was significantly greater than the sum of the gastrin responses to sham feeding alone and to 2.3 μg/kg atropine alone, indicating potentiation of vagal gastrin release by atropine. We conclude: (a) Unlike vagally mediated gastric acid secretion and pancreatic polypeptide release which can be blocked by atropine, vagal gastrin release is potentiated by atropine. This observation suggests the existence of a vagal-cholinergic pathway which normally (i.e., in the absence of atropine) inhibits gastrin release. (b) Because atropine (without sham feeding) increased basal gastrin levels, it is likely that the cholinergic pathway which inhibits gastrin release is active even when the vagus nerve is not stimulated by sham feeding.
Dietary Intake Is Associated with Phthalate Body Burden in a Nationally Representative Sample
Authors: Justin A. Colacino, T. Robert Harris, Arnold Schecter
Journal: Environmental Health Perspectives (2010)

Phthalates are compounds that are used in a wide range of consumer products. However, the contribution of dietary intake to phthalate exposure has not been well defined.The objective of this study was to assess the contribution of different food types to phthalate exposure. Phthalates are chemicals of concern because of the high levels measured in people and the environment, as well as the demonstrated toxicity in animal studies and limited epidemiological studies. Previous research, although limited, has suggested that phthalates contaminate food in various countries.We conducted an exploratory analysis of data collected as part of the 2003-2004 National Health and Nutrition Examination Survey (NHANES). Associations between dietary intake (assessed by a 24-hr dietary recall) for a range of food types (meat, poultry, fish, fruit, vegetable, and dairy) and phthalate metabolites measured in urine were analyzed using multiple linear regression modeling.We found that metabolites of di-(2-ethylhexyl) phthalate (DEHP) and high-molecular-weight phthalate metabolites were associated with the consumption of poultry. Monoethyl phthalate, the metabolite of diethyl phthalate (DEP), was associated with vegetable consumption, specifically tomato and potato consumption.These results, combined with results from previous studies, suggest that diet is an important route of intake for phthalates. Further research is needed to determine the sources of food contamination with these toxic chemicals and to describe the levels of contamination of U.S. food in a large, representative U.S. sample.
Results of portal decompression in patients with primary biliary cirrhosis.
Authors: R Spinsi, G Smith-Laing, O Epstein, S Sherlock
Journal: Gut (1981)

Twenty-five patients with primary biliary cirrhosis undergoing portal decompression have been followed up for a mean of 51 months. Five patients with decompensated cirrhosis died postoperatively. Overall five year survival of 66% is comparable with that for other forms of cirrhosis but none of the long-term survivors, including three patients with a precirrhotic stage of primary biliary cirrhosis at the time of surgery, developed significant portal-systemic encephalopathy. The results suggest that portal decompression may be the therapy of choice for patients with well-compensated primary biliary cirrhosis who suffer recurrent variceal haemorrhage.
Evaluating Open Access: Problems with the Program or the Studies?
Authors: Daren R. Anderson
Journal: Annals of Internal Medicine (2008)

LettersDecember 16, 2008Evaluating Open Access: Problems with the Program or the Studies?Daren R. Anderson, MDDaren R. Anderson, MDFrom Community Health Center, Inc., Middletown, CT 06457.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-12-200812160-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:By claiming that their study calls into question the benefits of advanced access, Mehrotra and colleagues (1) have misinterpreted and misconstrued their findings. What they have in fact demonstrated is simply that if a practice attempts to implement advanced access and fails, it will not realize any of the well-documented benefits of the system. Although reduction in third-next-available appointments for both “short” and “long” appointments is an improvement, it is in no way sufficient to claim that “advanced access” has been achieved. It is therefore no wonder that neither no-show rates nor staff and patient satisfaction improved ...Reference1. Mehrotra A, Keehl-Markowitz L, and Ayanian JZ. Implementing open-access scheduling of visits in primary care practices: a cautionary tale. Ann Intern Med. 2008;148:915-22 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Community Health Center, Inc., Middletown, CT 06457.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImplementing Open-Access Scheduling of Visits in Primary Care Practices: A Cautionary Tale Ateev Mehrotra , Lori Keehl-Markowitz , and John Z. Ayanian Evaluating Open Access: Problems with the Program or the Studies? Chris Salisbury Evaluating Open Access: Problems with the Program or the Studies? Arthur L. Kellermann Evaluating Open Access: Problems with the Program or the Studies? Ateev Mehrotra , Lori Keehl-Markowitz , and John Z. Ayanian Evaluating Open Access: Problems with the Program or the Studies? Mark F. Murray Metrics December 16, 2008Volume 149, Issue 12Page: 909-910KeywordsForecastingPrevention, policy, and public health ePublished: 16 December 2008 Issue Published: December 16, 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 3768: Comparison of breast density measured by dual energy x-ray Absorptiometry (DXA) with mammographic density among adult women
Authors: Gertraud Maskarinec, Yukiko Morimoto, Yihe Daida, Aurelie Laidevant, John A. Shepherd, Rachel Novotny
Journal: Cancer Research (2010)

Abstract Mammographic density, the distribution of fat, connective, and epithelial tissues in the female breast, is strongly associated with breast cancer and has been used as a biomarker for breast cancer risk among adult women. While use of mammography is limited due to concerns about radiation exposure, Dual Energy X-ray Absorptiometry (DXA), commonly available in medical care settings, has very low radiation. In this analysis, we compared breast density measured by DXA with mammographic density among adult women. We recruited 101 participants aged 30 years and older with a normal mammogram (defined as BIRADS categories 1 through 3) through Kaiser Permanente Hawaii. After completing a questionnaire asking for demographic, reproductive, anthropometric, and medical information, all women received DXA scans of both breasts, as well as of the whole body, using a GE Lunar Prodigy Bone Densitometer. On the DXA scans, the breast image was manually outlined and the following measures were computed: percent fibroglandular volume density (% FGV), absolute fibroglandular volume, total breast area, and volume. After digitizing the most recent craniocaudal (CC) and mediolateral (ML) mammograms, total breast area, dense area, and percent density were estimated using a computer-assisted method (Cumulus). For the overall population, mean % FGV was 38.8±14.3%, and mean percent density was 31.9±18.2% for CC views and 28.3±16.2% for ML views. Both DXA and mammographic measures showed high correlations between left and right breasts ranging from 0.85 to 0.98 (p &amp;lt;0.0001). When comparing DXA and mammographic measures, the correlation coefficients between % FGV and percent density were 0.76 for both CC and ML views (p &amp;lt;0.0001). Associations with common risk factors showed similar patterns for DXA and mammographic densities; in particular, the inverse associations with BMI and age at menarche were evident for both methods. Multilinear regression with stepwise selection indicated an explained variance of 0.57 for % FGV alone and 0.58 for % FGV plus parity. The current comparison suggests that DXA has the potential to provide a low-radiation option to evaluate breast density for women who do not undergo mammography. This may allow improved individualized risk assessment to identify women for targeted prevention strategies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3768.
Effect of Gastrin I and II on the Secretion of Intrinsic Factor
Authors: A. G. Wangel, S. T. Callender
Journal: BMJ (1965)

D Male 34 years Weight 85 kg. Histamine 40 /ug./kg. Gastrin 0-5 ? ., 15 ? 2-5 ? 3-5 1,100 1,100 500 Not 900 1-5 1-4 0-7 done 01 3,100 1,900 2,700 1,900 3,700 3-5 1-6 3-4 1-2 4-3 5,100 1,900 2,400 4,900 5,100 9-9 2-3 6-6 11-3 6-2 2,000 300 1,900 1,500 3,800 10-6 1-8 110 11-7 11-4 200 0 500 1,000 1,900 6-2 1-5 50 8-5 12-7 10,400 4,100 7,500 9,300 14,500 E Male 33 years Weight 80 kg. Histamine 40 jug./kg. Gastrin 0-5 ? ? 1;5 m 2*5 ? ? 3-5 600 2,500 1,300 300 1,000 1-8 2-6 0-4 1-0 1-3 4,300 2,900 3,000 3,900 8,500 5-6 3-2 21 4-2 10-5 7,100 2,100 5,500 7,900 5,300 11-4 30 7-7 16-4 17-5 4,600 1,100 5,600 2,800 2,600 15-7 2-6 12-2 14-3 22-9 500 300 1,500 1,700 1,000 2-9 0-8 8-6 8-4 17-3 16,500 6,400 15,600 16,300 17,400
Malabsorption of Folate Polyglutamates in Tropical Sprue
Authors: A. V. Hoffbrand, T. F. Necheles, N. Maldonado, E. Horta, R. Santini
Journal: BMJ (1969)

Malabsorption of folate polyglutamates prepared from yeast has been shown in eight patients with untreated tropical sprue and in three out of six patients receiving therapy for sprue. The absorptive defect for folate polyglutamates among these 14 patients occurred more frequently and in all but one patient more severely than for folic acid.Folate polyglutamates, the principal dietary form of folate, probably require deconjugation by the jejunal enzyme, folate conjugase, before absorption. The mean concentration of jejunal folate conjugase of 21 patients with untreated sprue and of 13 patients with sprue receiving therapy were both significantly less than the mean concentration in a control group. Nevertheless, all but five of the 34 patients had jejunal folate concentrations within the control range. There was no correlation in the individual patients between the jejunal folate conjugase concentration measured in vitro and the ability to absorb folate polyglutamates-nine patients having normal jejunal folate conjugase levels despite showing malabsorption of folate polyglutamates.
Elizabeth Findlay Hamilton
Authors: Robert Hunter, Jane Short, Elizabeth Bradford
Journal: BMJ (2006)

Pioneer of powered prosthetic limbs and fetal heart monitorsDavid Simpson, who was disabled by a war wound, retrained from accountancy to physics to devise solutions for medical problems.In the 1950s, when orthopaedic engineering was in its infancy, he pioneered the design and manufacture of controllable artificial limbs.He designed monitoring
Adaptive immunity in atherogenesis: new insights and therapeutic approaches
Authors: Andrew H. Lichtman, Christoph J. Binder, Sotirios Tsimikas, Joseph L. Witztum
Journal: Journal of Clinical Investigation (2013)

Many remarkable advances have improved our understanding of the cellular and molecular events in the pathogenesis of atherosclerosis. Chief among these is the accumulating knowledge of how the immune system contributes to all phases of atherogenesis, including well-known inflammatory reactions consequent to intimal trapping and oxidation of LDL. Advances in our understanding of the innate and adaptive responses to these events have helped to clarify the role of inflammation in atherogenesis and suggested new diagnostic modalities and novel therapeutic targets. Here we focus on recent advances in understanding how adaptive immunity affects atherogenesis.
Continuous Improvements in “Chain of Survival” Increased Survival After Out-of-Hospital Cardiac Arrests
Authors: Taku Iwami, Graham Nichol, Atsushi Hiraide, Yasuyuki Hayashi, Tatsuya Nishiuchi, Kentaro Kajino, Hiroshi Morita, Hidekazu Yukioka, Hisashi Ikeuchi, Hisashi Sugimoto, Hiroshi Nonogi, Takashi Kawamura
Journal: Circulation (2009)

Background— The impact of ongoing efforts to improve the “chain of survival” for out-of-hospital cardiac arrest (OHCA) is unclear. The objective of this study was to evaluate the incremental effect of changes in prehospital emergency care on survival after OHCA. Methods and Results— This prospective, population-based observational study involved consecutive patients with OHCA from May 1998 through December 2006. The primary outcome measure was 1-month survival with favorable neurological outcome. Multiple logistic regression analysis was used to assess factors that were potentially associated with better neurological outcome. Among 42 873 resuscitation-attempted adult OHCAs, 8782 bystander-witnessed arrests of presumed cardiac origin were analyzed. The median time interval from collapse to call for medical help, first cardiopulmonary resuscitation, and first shock shortened from 4 (interquartile range [IQR] 2 to 11) to 2 (IQR 1 to 5) minutes, from 9 (IQR 5 to 13) to 7 (IQR 3 to 11) minutes, and from 19 (IQR 13 to 22) to 9 (IQR 7 to 12) minutes, respectively. Neurologically intact 1-month survival after witnessed ventricular fibrillation increased from 6% (6/96) to 16% (49/297; P &lt;0.001). Among all witnessed OHCAs, earlier cardiopulmonary resuscitation (odds ratio per minute 0.89, 95% confidence interval 0.85 to 0.93) and earlier intubation (odds ratio per minute 0.96, 95% confidence interval 0.94 to 0.99) were associated with better neurological outcome. For ventricular fibrillation, only earlier shock was associated with better outcome (odds ratio 0.84, 95% confidence interval 0.80 to 0.88). Conclusions— Data from a large, population-based cohort demonstrate a continuous increase in OHCA survival with improvement in the chain of survival. The incremental benefit of early advanced care on OHCA survival is also suggested.
Management of medicines in residential homes.
Authors: E R Tallett
Journal: BMJ (1977)

nauseated and vomited.In addition to these well-known local irritant effects of zinc sulphate on the gastrointestinal tract, con- sideration must be given to potentially toxic side effects of the large and unphysiological concentrations of zinc achieved in human plasma with the recommended zinc sulphate regimen.In the light of these observations we feel that the current recommendations to treat acne vulgaris with 220 mg of zinc sulphate thrice daily is unwarranted owing to the excess quantity of zinc ion absorbed.There is an urgent need to investigate the dose effectiveness of zinc sulphate supplementation not only in patients with acne vulgaris but also in the various other conditions for which zinc has been recommended.This is being done in this department.
Joy of rapid responses: Summary of responses
Authors: Birte Twisselmann
Journal: BMJ (2004)

Random drug testing in schools fails screening criteriaEditor-Last month the prime minister, Tony Blair, lent his weight to random drug testing in schools in an interview for a downmarket newspaper. 1He proposed a national programme be implemented soon, adhering to unspecified central directives.The Department of Health has 19 criteria for introducing new screening programmes. 2 At least 18 of these 19 criteria are not met for widespread, wide spectrum drug urine analysis in schools.The remaining criterion is that the condition is an important health problem.Drug use in young people is indeed associated with many health risks, 3 but a single, positive urine test, for any illicit drug, is probably not meaningful in a clinical sense.Each schoolchild's context of use (family history, social and emotional development) is crucial to interpreting any supposed "drug career."Use by a homeless pregnant teenage runaway from local authority care with a history of deliberate self harm and high risk sex work to pay for her drugs may be very different from a single experimental use at home with adults during a family party.Three failed criteria are especially pertinent to screening for school age drug use:(1) There should be an agreed policy on the further diagnostic investigation of people with a positive test result and on the choices available to them.(2) There should be an effective treatment or intervention for patients identified through early detection.(3) Clinical management of the condition and patient outcomes should be optimised by all healthcare providers before participation in a screening programme.In three years of experience of school health provision for alcohol and drug problems and their related referral networks I do not know of one school that could satisfy these criteria, especially the underpinning policy of promoting informed choice for children and families. 2
Bronchodilator Effect of Inhaled Olprinone, a Phosphodiesterase 3 Inhibitor, in Asthmatic Patients
Authors: SHIGEHARU MYOU, MASAKI FUJIMURA, YUMIE KAMIO, YOSHIHISA ISHIURA, HIDEKI TACHIBANA, TATSUKI HIROSE, TAKUMA HASHIMOTO, TAMOTSU MATSUDA
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

The effect of topical administration of phosphodiesterase (PDE) 3 inhibitors on the airway is not clear. In order to examine the usefulness of inhaled PDE3 inhibitors in the treatment of asthma, we investigated the bronchodilator effect of inhaled olprinone, a newly developed PDE3 inhibitor, in nine asthmatic patients. On three separate study days, olprinone, salbutamol, or vehicle was administered in a double-blind and randomized fashion, and pulmonary functions were assessed over 60 min. Significant increases in FEV1 were observed until 45 min after inhalation of olprinone without adverse cardiovascular effects. Mean maximal increases in FEV1 were 16.0 ± 4.0 and 20.5 ± 4.2% with olprinone and salbutamol, respectively. The bronchodilator effect of olprinone was greater than that of salbutamol in four of the nine patients. These results suggest that the inhaled PDE3 inhibitor has a bronchodilator effect in asthmatic patients.