tbuckley/cabot-search huggingface dataset:
Post-polypectomy complications: high risk in the cecum
Authors: Antonio Gimeno-García, Enrique Quintero
Journal: Endoscopy (2014)

Colorectal cancer (CRC) is the third most frequently occurring cancer in the world [1]. Several randomized trials have shown that screening significantly reduces CRC incidence and mortality [2] [3] [4] The benefit of screening strategies is largely dependent on the effectiveness of colonoscopy, the procedure onto which all screening strategies converge. Colonoscopy allows the detection and removal of advanced adenomas, the precancerous lesions responsible for most CRCs. Endoscopic polypectomy is generally considered a safe procedure, and complications are frequently mild. However, the risk of life-threatening complications does exist, and the likelihood of serious adverse events associated with colonoscopy with polypectomy is almost nine times that of colonoscopy without polypectomy [5]. The most severe post-polypectomy complications are bleeding and perforation. Research on predictive factors for major post-polypectomy complications is of the utmost importance for the development of specific management strategies
Apoptosis of tumoral and nontumoral lymphoid cells is induced by both mdm2 and p53 antisense oligodeoxynucleotides
Authors: Corinne Capoulade, Lluis M. Mir, Karine Carlier, Yann Lécluse, Cécile Tétaud, Zohair Mishal, Joëlle Wiels
Journal: Blood (2001)
Elevated C-Reactive Protein Levels in Patients with Polypoidal Choroidal Vasculopathy and Patients with Neovascular Age-Related Macular Degeneration
Authors: Masato Kikuchi, Makoto Nakamura, Kohei Ishikawa, Toshimitsu Suzuki, Hiroaki Nishihara, Tomomi Yamakoshi, Kazuko Nishio, Kentaro Taki, Toshimitsu Niwa, Nobuyuki Hamajima, Hiroko Terasaki
Journal: Ophthalmology (2007)
Erythropoietic Protoporphyria: A New Clinical Syndrome.
Authors: Allan G. Redeker
Journal: Annals of Internal Medicine (1964)

s1 October 1964Erythropoietic Protoporphyria: A New Clinical Syndrome.Allan G. Redeker, M.D.Allan G. Redeker, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-811_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptErythropoietic protoporphyria, a new medical syndrome first described in 1961, is a familial, photocutaneous disorder, inherited as a Mendelian dominant. The hallmark of the disease is a marked increase in the erythrocyte protoporphyrin content. The fecal protoporphyrin excretion is similarly increased, but protoporphyrin does not appear in the urine. The photosensitivity is due to protoporphyrin circulating in the plasma. The source of the plasma porphyrin may be either hepatic or erythropoietic or both. In some families, asymptomatic individuals with increased erythrocyte protoporphyrin values but no porphyrin in the plasma have been observed. Photosensitivity begins early in childhood and may present... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 811-811KeywordsBlood plasmaExcretionPorphyrinsUrine Issue Published: 1 October 1964 PDF downloadLoading ...
Anti–Glypican 3 Antibody as a Potential Antitumor Agent for Human Liver Cancer
Authors: Takahiro Ishiguro, Masamichi Sugimoto, Yasuko Kinoshita, Yoko Miyazaki, Kiyotaka Nakano, Hiroyuki Tsunoda, Izumi Sugo, Iwao Ohizumi, Hiroyuki Aburatani, Takao Hamakubo, Tatsuhiko Kodama, Masayuki Tsuchiya, Hisafumi Yamada-Okabe
Journal: Cancer Research (2008)

Abstract Human glypican 3 (GPC3) is preferentially expressed in the tumor tissues of liver cancer patients. In this study, we obtained a monoclonal antibody (mAb) against the COOH-terminal part of GPC3, which induced antibody-dependent cellular cytotoxicity (ADCC). The mAb, designated GC33, exhibited marked tumor growth inhibition of s.c. transplanted Hep G2 and HuH-7 xenografts that expressed GPC3 but did not inhibit growth of the SK-HEP-1 that was negative for GPC3. GC33 was efficacious even in an orthotopic model; it markedly reduced the blood α-fetoprotein levels of mice intrahepatically transplanted with Hep G2 cells. Humanized GC33 (hGC33) was as efficacious as GC33 against the Hep G2 xenograft, but hGC33 lacking carbohydrate moieties caused neither ADCC nor tumor growth inhibition. Depletion of CD56+ cells from human peripheral blood mononuclear cells markedly abrogated the ADCC caused by hGC33. The results show that the antitumor activity of hGC33 is mainly attributable to ADCC, and in human, natural killer cell–mediated ADCC is one possible mechanism of the antitumor effects by GC33. hGC33 will provide a novel treatment option for liver cancer patients with GPC3-positive tumors. [Cancer Res 2008;68(23):9832–8]
Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes
Authors: Young Min Cho, Byung-Soo Youn, Hyewon Lee, Namseok Lee, Sung-Shik Min, Soo Heon Kwak, Hong Kyu Lee, Kyong Soo Park
Journal: Diabetes Care (2006)

The dysregulation of adipokines is closely associated with the pathogenesis of insulin resistance and type 2 diabetes. Retinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide a link between obesity and insulin resistance. Here, we examined the relation between plasma RBP4 concentrations and various metabolic parameters in humans.An enzyme-linked immunosorbent assay was developed to measure human RBP4 plasma concentrations, which were then compared with various parameters related to insulin resistance in subjects with normal glucose tolerance (NGT; n = 57), impaired glucose tolerance (IGT; n = 48), and type 2 diabetes (n = 49).Plasma RBP4 concentrations were higher in the IGT and type 2 diabetic groups than in the NGT group (median 18.9 [range 11.2-45.8], 20.9 [9.9-48.5], and 18.1 microg/ml [9.3-30.5], respectively). However, no difference was found between plasma RBP4 concentrations in the IGT and type 2 diabetic groups. Plasma RBP4 concentrations were found to be associated with sex, waist circumference, fasting plasma glucose, and insulin resistance. Of these, sex and fasting plasma glucose levels were found to be independent determinants of plasma RBP4 concentration.Plasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance.
Effects of perforated appendicitis in girls on subsequent fertility.
Authors: P Puri, E J Guiney, B O'Donnell, E P McGuinness
Journal: BMJ (1984)

physical treatments hitherto considered to have a specific antidepressant action are not given."4Our study was conductedon clinically selected patients from a fixed catchment area.Retrospective analysis of the rate of prescription of electroconvulsive therapy showed no alteration during the trial.The difference in outcome in favour of real treatment at both two and four weeks was greater in our study than in the Northwick Park trial.In our trial both the group of patients with depression and delusions and the group with depression and retardation were clearly responsive to electro- convulsive therapy, whereas in the Northwick Park study only the group with delusions showed unequivocal benefit.The group given placebo treatment had achieved a degree of recovery at six months comparable with that of the treatment group, but the recovery was considerably slower.Both treatment groups received a wide variety of treatments after the four weeks of the trial.We believe that our data indicate that electroconvulsive therapy is an effective and rapidly acting treatment for severe depressive illness and that its use should be favoured in patients at risk of suicide because of the rapidity of response.We thank the patients, relatives, nurses, and doctors of Leicester- shire, whose cooperation and forbearance made this study possible.A particular debt of gratitude is due to the nurses and anaesthetists in the treatment centres and to the ward staff, who had to tolerate an additional uncertainty in caring for seriously ill patients.
Microdistribution and Long-term Retention of 239Pu (NO3)4 in the Respiratory Tracts of an Acutely Exposed Plutonium Worker and Experimental Beagle Dogs
Authors: Christopher E. Nielsen, Dulaney A. Wilson, Antone L. Brooks, Stacey L. McCord, Gerald E. Dagle, Anthony C. James, Sergei Y. Tolmachev, Brian D. Thrall, William F. Morgan
Journal: Cancer Research (2012)

The long-term retention of inhaled soluble forms of plutonium raises concerns as to the potential health effects in persons working in nuclear energy or the nuclear weapons program. The distributions of long-term retained inhaled plutonium-nitrate [(239)Pu (NO(3))(4)] deposited in the lungs of an accidentally exposed nuclear worker (Human Case 0269) and in the lungs of experimentally exposed beagle dogs with varying initial lung depositions were determined via autoradiographs of selected histologic lung, lymph node, trachea, and nasal turbinate tissue sections. These studies showed that both the human and dogs had a nonuniform distribution of plutonium throughout the lung tissue. Fibrotic scar tissue effectively encapsulated a portion of the plutonium and prevented its clearance from the body or translocation to other tissues and diminished dose to organ parenchyma. Alpha radiation activity from deposited plutonium in Human Case 0269 was observed primarily along the subpleural regions while no alpha activity was seen in the tracheobronchial lymph nodes of this individual. However, relatively high activity levels in the tracheobronchial lymph nodes of the beagles indicated the lymphatic system was effective in clearing deposited plutonium from the lung tissues. In both the human case and beagle dogs, the appearance of retained plutonium within the respiratory tract was inconsistent with current biokinetic models of clearance for soluble forms of plutonium. Bound plutonium can have a marked effect on the dose to the lungs and subsequent radiation exposure has the potential to increase cancer risk.
Workplace bullying in NHS community trust: staff questionnaire survey
Authors: L. Quine
Journal: BMJ (1999)

To determine the prevalence of workplace bullying in an NHS community trust; to examine the association between bullying and occupational health outcomes; and to investigate the relation between support at work and bullying.Questionnaire survey.NHS community trust in the south east of England.Trust employees.Measures included a 20 item inventory of bullying behaviours designed for the study, the job induced stress scale, the hospital anxiety and depression scale, the overall job satisfaction scale, the support at work scale, and the propensity to leave scale.1100 employees returned questionnaires-a response rate of 70%. 421 (38%) employees reported experiencing one or more types of bullying in the previous year. 460 (42%) had witnessed the bullying of others. When bullying occurred it was most likely to be by a manager. Two thirds of the victims of bullying had tried to take action when the bullying occurred, but most were dissatisfied with the outcome. Staff who had been bullied had significantly lower levels of job satisfaction (mean 10.5 (SD 2. 7) v 12.2 (2.3), P<0.001) and higher levels of job induced stress (mean 22.5 (SD 6.1) v 16.9 (5.8), P<0.001), depression (8% (33) v 1% (7), P<0.001), anxiety (30% (125) v 9% (60), P<0.001), and intention to leave the job (8.5 (2.9) v 7.0 (2.7), P<0.001). Support at work seemed to protect people from some of the damaging effects of bullying.Bullying is a serious problem. Setting up systems for supporting staff and for dealing with interpersonal conflict may have benefits for both employers and staff.
Catheterization and Mortality in Elderly Patients With Acute Myocardial Infarction
Authors: Kathryn Davis
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I read with great interest the recent article by Dr McClellan and colleagues<sup>1</sup>regarding the treatment of AMI in the elderly. McClellan et al are to be commended for their novel approach to the analysis of outcomes after an AMI. While they concluded that there was only a modest and possibly no true incremental effect of catheterization and associated revascularization procedures on mortality after an AMI in the elderly, they failed to mention a key point regarding the issue of age itself and AMI. While it has been reported that the in-hospital mortality after AMI in the elderly can be as high as 17.8% for patients aged 75 years and older and 2% for those aged 55 years and younger,<sup>2</sup>Smith et al<sup>3</sup>have reported age itself not to be an independent risk factor for mortality after an AMI. We presented data on 208
Late snaring of Lillehei-Kaster prosthesis by a fragment of left atrial monitoring catheter.
Authors: P R Behl, A H Brown
Journal: Thorax (1983)

Professor Cochrane, curiously, has taken issue with only one of the five references that I provided in support of the idea that there is a relationship between coal dust exposure and risk of emphysema and disabling airways obstruction.The paper by Love and Miller deals with one aspect of
Control of Communicable Diseases in Man
Authors: Swailem S. Hennein
Journal: JAMA (1982)

This is an official report of the American Public Health Association on known communicable diseases in man, past and present. It is published in a pocket-size paperback to serve as a ready manual for reference on some 160 diseases including "the rare and exotic," synoptically reviewed with regard to identification, infectious agent, occurrence, reservoir, mode of transmission, incubation period, period of communicability, and methods of control, prevention, and patient and epidemic management. Each is given the latest World Health Organization disease classification number. This is the 13th impression of a handbook in circulation for more than 60 years. It has undergone periodic revisions by authorities in the field serving as an editorial board, members and contributors, as well as liaison representatives. Many are known experts, with impressive records of award-winning scientific investigation in related disciplines and field work in disease control, both in this country and overseas. The book was
Circulating human leucocyte elastase in patients with inflammatory bowel disease.
Authors: E O Adeyemi, S Neumann, V S Chadwick, H J Hodgson, M B Pepys
Journal: Gut (1985)

<h3>Abstract</h3> Swim-up is a sperm purification method that is being used daily in andrology labs around the world as a simple step for <i>in vitro</i> sperm selection. This method accumulates the most motile sperm in the upper fraction and leaves sperm with low or no motility in the lower fraction but the underlying reasons are not fully understood. In this article, we compare metabolic rate, motility and sperm tail length of bovine sperm cells of the upper and lower fraction. The metabolic assay platform reveals oxygen consumption rates and extracellular acidification rates simultaneously and thereby delivers the metabolic rates in real time. Our study confirms the upper fraction of bull sperm has improved motility compared to the cells in the lower fraction and shows higher metabolic rates. This pattern was consistent across media of two different levels of viscosity. Sperm with longer flagella are selected in the upper fraction. We conclude that the motility-based separation of the swim-up technique is based on metabolic differences. Metabolic assays could serve as additional or alternative, label-free method to evaluate sperm quality, which is likely particularly useful in cases of asthenozoospermia and teratospermia. Furthermore, metabolic measurements of sperm cells can reveal differences in metabolic pathways in different environments.
<i>Le Liquide Céphalo-Rachidien.</i> Par J. A. Sicard, Chef de Clinique des Maladies Nerveuses à la Saltpêtrière, avec préface du Professeur Brissaud. P. 192. Paris, Masson et Cie., 1902
Authors: I. H. Coriat
Journal: American Journal of Psychiatry (1903)
Measurement of acidic aerosol species in eastern Europe: implications for air pollution epidemiology.
Authors: M Brauer, T S Dumyahn, J D Spengler, K Gutschmidt, J Heinrich, H E Wichmann
Journal: Environmental Health Perspectives (1995)

A large number of studies have indicated associations between particulate air pollution and adverse health outcomes. Wintertime air pollution in particular has been associated with increased mortality. Identification of causal constituents of inhalable particulate matter has been elusive, although one candidate has been the acidity of the aerosol. Here we report measurements of acidic aerosol species made for approximately 1.5 years in Erfurt, Germany, and Sokolov, Czech Republic. In both locations, the burning of high-sulfur coal is the primary source of ambient air pollution. Twenty-four-hour average measurements were made for PM10, [particulate matter with an aerodynamic diameter (da) &lt; or = 10 microns], as well as fine particle (da &lt; 2.5 microns) H+ and SO4(2-) for the entire study. Additionally, separate day and night measurements of fine particle H+, SO4(2-), NO3-, and NH4+ and the gases, SO2, HNO3, HONO, and NH3 were collected with an annular denuder/filter pack system over a 7-month (late winter-summer) period with additional measurements during pollution episodes the following winter. At both sites, 24-hr SO2 (mean concentrations of 52 micrograms/m3, with peak levels of &gt; 585 micrograms/m3) and PM10 (mean concentration 60 micrograms m3) concentrations were quite high. However, aerosol SO4(2-) concentrations (mean concentration of approximately 10 micrograms/m3) were not as great as expected given the high SO2 concentrations, and acidity was very low (mean concentration of &lt; 1 microgram/m3, with peak levels of only 7 micrograms/m3). Low acidity is likely to be the result of NH3 neutralization and slow conversion of SO2 to SO4(2-).(ABSTRACT TRUNCATED AT 250 WORDS)
PARALDEHYDE, SUGAR AND GERM DISEASES.
Authors: J. R. UHLER
Journal: JAMA (1884)

[Read before the Baltimore Academy of Medicine, November 20, 1883.] The substances that I am about to describe are interesting alike for their properties and suggestiveness, since they belong to a class of bodies that, through fermentation and degradation, are closely allied with alcohol and acetic acid. Paraldehyde was first employed by the Italians, and if we can trust accounts in the journals and individual experience, it is a very useful addition to the list of antispasmodic and sleep-producing agents. In both the concentrated and dilute state it smells and tastes somewhat like sweet spirits of nitre, but when a drop is placed on the back of the tongue, a more pungent, musty, and bitter sensation will be experienced. The odor from its vapor quickly fills an apartment, but it seems to evaporate more slowly than chloroform or ether. Its chemical formula is C<sup>6</sup>H<sup>12</sup>O<sup>3</sup>, and, as the name
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
Authors: Christopher A Haiman, Gary K Chen, William J Blot, Sara S Strom, Sonja I Berndt, Rick A Kittles, Benjamin A Rybicki, William B Isaacs, Sue A Ingles, Janet L Stanford, W Ryan Diver, John S Witte, Ann W Hsing, Barbara Nemesure, Timothy R Rebbeck, Kathleen A Cooney, Jianfeng Xu, Adam S Kibel, Jennifer J Hu, Esther M John, Serigne M Gueye, Stephen Watya, Lisa B Signorello, Richard B Hayes, Zhaoming Wang, Edward Yeboah, Yao Tettey, Qiuyin Cai, Suzanne Kolb, Elaine A Ostrander, Charnita Zeigler-Johnson, Yuko Yamamura, Christine Neslund-Dudas, Jennifer Haslag-Minoff, William Wu, Venetta Thomas, Glenn O Allen, Adam Murphy, Bao-Li Chang, S Lilly Zheng, M Cristina Leske, Suh-Yuh Wu, Anna M Ray, Anselm J M Hennis, Michael J Thun, John Carpten, Graham Casey, Erin N Carter, Edder R Duarte, Lucy Y Xia, Xin Sheng, Peggy Wan, Loreall C Pooler, Iona Cheng, Kristine R Monroe, Fredrick Schumacher, Loic Le Marchand, Laurence N Kolonel, Stephen J Chanock, David Van Den Berg, Daniel O Stram, Brian E Henderson
Journal: Nature Genetics (2011)
Could Blood Ketone Monitoring Be A Tool for Managing Gestational Diabetes Mellitus?
Authors: Henri Gin, Anne Vambergue, Claudine Vasseur, Vincent Rigalleau, Philippe Dufour, Agnes Roques, Pierre Fontaine
Journal: Diabetes Care (2006)

Nutritional management of gestational diabetes mellitus (GDM) is based on guidelines from diabetology societies (1). Ketonuria is often monitored, but clear management guidelines have not been established. Home-based methods of measuring ketonemia are available. We believe that it is important to evaluate the utility of this tool in GDM.

We measured ketonemia in a control population of pregnant women and a GDM population. Pregnant women were systematically screened for GDM between the 24th and 28th weeks (75-g oral glucose tolerance test [OGTT], World Health Organization guidelines). A total of 56 women (29.98 ± 4.86 years of age, prepregnancy BMI 23.14 ± 4.62 kg/m2 …
Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis
Authors: Joshua L. Hood, Roman Susana San, Samuel A. Wickline
Journal: Cancer Research (2011)

Exosomes are naturally occurring biological nanovesicles utilized by tumors to communicate signals to local and remote cells and tissues. Melanoma exosomes can incite a proangiogenic signaling program capable of remodeling tissue matrices. In this study, we show exosome-mediated conditioning of lymph nodes and define microanatomic responses that license metastasis of melanoma cells. Homing of melanoma exosomes to sentinel lymph nodes imposes synchronized molecular signals that effect melanoma cell recruitment, extracellular matrix deposition, and vascular proliferation in the lymph nodes. Our findings highlight the pathophysiologic role and mechanisms of an exosome-mediated process of microanatomic niche preparation that facilitates lymphatic metastasis by cancer cells.
Risk and Outcome in Anesthesia
Authors: M. Jane Matjasko
Journal: JAMA (1988)

After reading this book, one has many more questions than answers regarding risk and outcome in anesthesia. Risk and patient safety in the perioperative period are addressed through specific critical questions, which provide fertile areas for research by the current and next generations of anesthesiologists. There are 27 contributors to this for the most part well-written and well-or-ganized text. The first six chapters describe perianesthetic and perioperative risk system by system, eg, cardiovascular, pulmonary, endocrine, gastrointestinal, psychiatric, and hematologic. The final nine chapters relate to subspecialty areas such as critical care and pain, as well as a lucid description of the medicolegal aspects of anesthesia practice useful for practitioners at any stage in their careers. The bibliographies following each chapter are comprehensive and up-to-date. Many of the discussions and therefore conclusions are hampered by a paucity of objective outcome data. This stimulates the reader to reexamine rigid approaches to many