Pheochromocytoma and Vasodepressor Response to Saralasin
Authors: EDWARD T. ZAWADA
Journal: Annals of Internal Medicine (1979)

Letters1 September 1979Pheochromocytoma and Vasodepressor Response to SaralasinEDWARD T. ZAWADA JR., M.D., LESLIE DORNFELD, M.D., MORTON MAXWELL, M.D., LEONARD MARKS, M.D., JOSEPH J. KAUFMAN, M.D.EDWARD T. ZAWADA JR., M.D.Search for more papers by this author, LESLIE DORNFELD, M.D.Search for more papers by this author, MORTON MAXWELL, M.D.Search for more papers by this author, LEONARD MARKS, M.D.Search for more papers by this author, JOSEPH J. KAUFMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-3-494_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although a severe delayed hypertensive crisis has been reported in a patient with a pheochromocytoma after saralasin infusion (1) we have seen a patient with both renovascular hypertension and an extra-adrenal pheochromocytoma who had only a sustained vasodepressor response to saralasin.A 10-year-old white boy presented with sudden onset of severe headaches and hypertension in February 1976. Blood pressure was 210/130 mm Hg. Fundi were grade II. Heart and lung examination findings were unremarkable except for sinus tachycardia. A 24-h urine contained 7.9 mg of vanillylmandelicacid (normal range, 1 to 10 mg) and 226 mg of catecholamines...References1. DUNNDE CARVALHOKEMHIGGINSFROHLICH FJDJE. Pheochromocytoma crisis induced by saralasin: relation of angiotensin analogue to catecholamine release. N Engl J Med. 1976;295:605-7. CrossrefMedlineGoogle Scholar2. MARKSMAXWELLKAUFFMAN LMJ. Renin, sodium, and vasodepressor response to saralasin in renovascular and essential hypertension. Ann Intern Med. 1977;87:176-82. LinkGoogle Scholar3. MAXWELLVARADYZAWADABURKHALTERWAKSMARKS MPEJUL. Maximal discrimination of renovascular from essential hypertension by the saralasin test. Clin Sci Mol Med. 1978;55:297s-9s. Google Scholar4. RÖCKELHEIDLANDAPPELPALM AAED. Depressor effect of saralasin in hypertensive crisis due to pheochromocytoma. N Engl J Med. 1977;296:50-1. Letter. CrossrefMedlineGoogle Scholar5. VAN HOOGDALEMDONKERBRENTJENSVAN DER HEMOOSTERHUIS PAJGJ. Partial correction of hypertension by angiotensin II blockade in a patient with pheochromocytoma. Acta Med Scand. 1977;201:395-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD T. ZAWADAJR., M.D.; LESLIE DORNFELD, M.D.; MORTON MAXWELL, M.D.; LEONARD MARKS, M.D.; JOSEPH J. KAUFMAN, M.D.Affiliations: UCLA Cedars-Sinai Medical Centers Los Angeles, CA 90024 and 90048 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdverse Drug Reactions in Patients with PhaeochromocytomaAdvances in Diagnosis and Treatment of Adrenal TumorsPheochromocytoma: Clinical manifestations and diagnostic testsUse of saralasin to detect renovascular hypertension in childhood 1 September 1979Volume 91, Issue 3Page: 494-495KeywordsBlood pressureCatecholaminesHeartHypertensionLungsPheochromocytomaTachycardiaUrine ePublished: 1 December 2008 Issue Published: 1 September 1979 PDF downloadLoading ...