tbuckley/cabot-search huggingface dataset:
Hepatocytes may produce laminin in fibrotic liver and in primary culture
Authors: Bruno Clément, Pierre-Yves Rescan, Georges Baffet, Olivier Loréal, Dominique Lehry, Jean-Pierre Campion, André Guillouzo
Journal: Hepatology (1988)

Previous studies have shown that laminin is present in basement membranes in normal liver but failed to identify cellular sources. We have investigated the extracellular and intracellular distribution of laminin in normal rat and human liver, in fibrotic human liver and in primary hepatocyte cultures from both species by light and electron microscopy using the indirect immunoperoxidase technique. In normal liver from both species, antibodies to laminin strongly stained basement membranes and formed discontinuous discrete deposits in the wall of the sinusoid. Vascular endothelial and bile duct cells as well as fat-storing cells and sinusoidal endothelial cells strongly stained for this glycoprotein while hepatocytes were negative. In fibrotic human liver, increased amounts of extracellular laminin were usually found. Continuous deposition in the space of Disse was observed in some cases. In addition to fat-storing cells and endothelial cells, hepatocytes were also sometimes positive. Normal rat and human hepatocytes synthesize and secrete laminin in conventional culture, but it remains soluble in the medium. By contrast, in coculture with another rat liver cell type, laminin accumulated around hepatocyte cords. These observations suggest that fat-storing cells and endothelial cells are the major sites of production of laminin in normal liver. However, when their environment is altered (e.g., liver injury, culture), adult hepatocytes are able to synthesize detectable amounts of laminin.
Leptin in the human stomach
Authors: S CINTI
Journal: Gut (2001)

Editor,—After the report in 1998 by Bado and colleagues1 describing the presence of leptin in rat stomach, we have recently reported the first evidence of leptin in the stomach mucosa of humans.2 It was shown that the cells in the lower half of the stomach glands were clearly immunoreactive for leptin, and both leptin mRNA and leptin protein in the human gastric epithelium were detected. Western blot analysis showed the presence of a 16 kDa band corresponding to leptin and a 19 kDa band which, as suggested for rats,1 could represent a leptin precursor. It was also shown that secretory granules of chief cells contain this hormone, suggesting that gastric leptin could function in the short term …
Epidemiology of hepatitis b e antigen and antibody in mentally retarded hbsag carriers
Authors: Ghanshyam Lohiya, Sunita Lohiya, Vinh Trong Ngo, Ramona Crinella
Journal: Hepatology (1986)

Screening for HBeAg and anti–HBe was performed on 133 carriers of HBsAg in aninstitution for the mentally retarded. By radioimmunoassay, the prevalences of HBeAg and anti–HBe were determined to be 16 and 78%, respectively. HBeAg prevalence was significantly different in the following pairs of carriers: 70% in blacks, 10% in whites, and 35% incarriers with Down's syndrome, 8% in carriers without Down's syndrome. Mean age of HBeAg–positive carriers (25.7 years) was lower than HBeAg–negative carriers (29.6 years, p &lt; 0.05). SGPT levels were abnormal in 66% of HBeAg–positive and 25% of HBeAg–negative carriers (p &lt; 0.01). This suggests an association between HBeAg positivity andfunctional liver impairment.
Reversible sideroblastic anemia associated with the tetracycline analogue COL‐3
Authors: Michelle A. Rudek, McDonald Horne, William D. Figg, William Dahut, Valerie Dyer, James M. Pluda, Eddie Reed
Journal: American Journal of Hematology (2001)

Abstract Eight of 35 patients with cancer receiving COL‐3, a tetracycline derivative with antiangiogenic properties, developed anemia while on treatment. All of these patients were enrolled on an approved Phase I clinical trial at the National Cancer Institute. Three of these patients had bone marrow examinations that revealed ringed sideroblasts. This paper describes these cases. Am. J. Hematol. 67:51–53, 2001. Published 2001 Wiley‐Liss, Inc.
Radiographic Emphysema Predicts Low Bone Mineral Density in a Tobacco-exposed Cohort
Authors: Jessica Bon, Carl R. Fuhrman, Joel L. Weissfeld, Steven R. Duncan, Robert A. Branch, Chung-Chou H. Chang, Yingze Zhang, Joseph K. Leader, David Gur, Susan L. Greenspan, Frank C. Sciurba
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Studies demonstrating an association between chronic obstructive pulmonary disease and low bone mineral density (BMD) implicate factors distinct from treatments and severity of lung disease in the pathogenesis of osteoporosis. Whereas emphysema has been independently associated with vascular disease and other comorbidities, its association with BMD has not been well studied.
A Phase I Study of Vandetanib in Combination with Vinorelbine/Cisplatin or Gemcitabine/Cisplatin as First-Line Treatment for Advanced Non-small Cell Lung Cancer
Authors: Fiona H. Blackhall, Mary O'Brien, Peter Schmid, Marianne Nicolson, Paul Taylor, Tsveta Milenkova, Sarah J. Kennedy, Nick Thatcher
Journal: Journal of Thoracic Oncology (2010)
The rate heterogeneity of nonsynonymous substitutions in mammalian mitochondrial genes
Authors: X. Xia
Journal: Molecular Biology and Evolution (1998)

Substitution rates at the three codon positions (r1, r2, and r3) of mammalian mitochondrial genes are in the order of r3 > r1 > r2, and the rate heterogeneity at the three positions, as measured by the shape parameter of the gamma distribution (alpha 1, alpha 2, and alpha 3), is in the order of alpha 3 > alpha 1 > alpha 2. The causes for the rate heterogeneity at the three codon positions remain unclear and, in particular, there has been no satisfactory explanation for the observation of alpha 1 > alpha 2. I attempted to dissect the causes of rate heterogeneity by studying the pattern of nonsynonymous substitutions with respect to codon positions in 10 mitochondrial genes from 19 mammalian species. Nonsynonymous substitutions involve more different amino acid replacements at the second than at the first codon position, which results in r1 > r2. The difference between r1 and r2 increases with the intensity of purifying selection, and so does the rate heterogeneity in nonsynonymous substitutions among sites at the same codon position. All mitochondrial genes appear to have functionally important and unimportant codons, with the latter having all three codon positions prone to nonsynonymous substitutions. Within the functionally important codons, the second codon position is much more conservative than the codon position. This explains why alpha 1 > alpha 2. The result suggests that overweighting of the second codon position in phylogenetic analysis may be a misguided practice.
Total Lesion Glycolysis Determined per RECIST 1.1 Criteria Predicts Survival in EGFR Mutation-Negative Patients With Advanced Lung Adenocarcinoma
Authors: Tsung-Ying Ho, Pai-Chien Chou, Cheng-Ta Yang, Ngan-Ming Tsang, Tzu-Chen Yen
Journal: Clinical Nuclear Medicine (2015)

Objective The aim of this retrospective study was to investigate the clinical impact of 18F-FDG PET in patients with advanced lung adenocarcinoma stratified according to the epidermal growth factor receptor (EGFR) mutation status. Patients and Methods A total of 56 patients with advanced lung adenocarcinoma were included in the study. Thirty-one patients (55%) were EGFR mutation-positive, whereas the remaining 25 (45%) participants tested negative for EGFR mutations. All of the patients underwent 18F-FDG PET/CT for pretreatment planning. The main outcome measure was overall survival (OS) at 24 months. The following 18F-FDG PET/CT-derived variables were tested for their associations with OS: main tumor SUVmax, main tumor total lesion glycolysis, and target lesions TLG determined per RECIST (Response Evaluation Criteria In Solid Tumors) 1.1 criteria (TLGRECIST). We also investigated the clinical characteristics in relation to OS and EGFR mutation status. Results In EGFR mutation-positive patients, neither the clinical characteristics nor 18F-FDG PET/CT-derived parameters were significantly associated with OS. In contrast, univariate analysis identified male sex, a positive history of smoking, and TLGRECIST greater than or equal to 412 g as adverse prognostic factors for OS in EGFR mutation-negative patients. After adjustment for potential confounders in multivariate analysis, TLGRECIST was the sole independent predictor of OS in this subgroup. Conclusions TLG determined per RECIST 1.1 criteria is an independent predictor of OS in EGFR mutation-negative patients with advanced lung adenocarcinoma. Further studies are needed to investigate whether this parameter may be a promising tool for stratifying such patients for risk-adapted therapies.
Fatal Reactivation of Hepatitis B with Temozolomide
Authors: Jai Grewal, Caryl A. Dellinger, W.K.A. Yung
Journal: New England Journal of Medicine (2007)

To the Editor: Encouraging results have led to the use of temozolomide as a first-line therapy for glioblastoma.1 We report on a case of temozolomide-associated reactivation of hepatitis B, a compl...
23 Nadolol+Isosorbide-5-mononitrate (NAD+ISMN) vs NAD+ISMN + endoscopic band ligation in the prevention of rebleeding in patients with cirrhosis. Preliminary results of a multicenter RCT
Authors: J.C. Garcia-Pagan, C. Villanueva, A. Albillos, R. Bañares, R. Planas, M. Casado, J. Bosch
Journal: Journal of Hepatology (2006)
Local ablation vs. resection for the treatment of hepatocellular carcinoma
Authors: Jia-Horng Kao, Ding-Shinn Chen
Journal: Hepatology (2006)

We read with great interest and enthusiasm the AASLD practice guidelines, "Management of Hepatocellular Carcinoma" where the current status of surveillance for hepatocellular carcinoma (HCC) as well as diagnosis, staging, and treatment of patients with HCC was comprehensively reviewed.1 Specific evidence supporting recommendations were provided and areas requiring active research noted. In the treatment section regarding percutaneous ablation, we concurred this is the best treatment option for patients with early stage HCC who are not suitable for resection or transplantation. Nevertheless, the statement that there are no randomized controlled trials (RCT) comparing local ablation to resection may be somewhat misleading and thus needs clarification. In Taiwan where chronic viral hepatitis and HCC are endemic,2 we have conducted a prospective study to compare tumor recurrence and survival among patients with small HCC after surgical resection or percutaneous ethanol injection therapy.3 In this study, a total of 76 eligible patients were randomly assigned to two groups based on treatment. By using Cox regression model and Kaplan-Meier survival analysis, our results showed no statistical significance for tumor recurrence and a similar survival benefit between the two treatment groups. Although the number of patients in this study is relatively small, our observations clearly imply that percutaneous ethanol injection therapy appears to be as safe and effective as surgical resection, and both treatments can be considered first-line therapeutic options for small HCC. With these encouraging results, further larger prospective randomized controlled studies are awaited to compare other local ablation modalities (radiofrequency, microwave, laser or cryotherapy) with surgical resection for the treatment of small HCC. Jia-Horng Kao* , Ding-Shinn Chen*, * Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Graduate Institute of Clinical Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Hepatitis Research Center, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Clomipramine-Induced Diabetes
Authors: Nicola Mumoli
Journal: Annals of Internal Medicine (2008)

Letters21 October 2008Clomipramine-Induced DiabetesNicola Mumoli, MD and Marco Cei, MDNicola Mumoli, MDFrom Ospedale Civile Livorno, 57100 Livorno, Italy.Search for more papers by this author and Marco Cei, MDFrom Ospedale Civile Livorno, 57100 Livorno, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-8-200810210-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Clomipramine is a tricyclic agent with both antidepressant and antiobsessional properties. Like other tricyclics, clomipramine inhibits uptake of norepinephrine, dopamine, and serotonin. Clomipramine has anticholinergic side effects: retention of urine, reduced intestinal motility, increased eye pressure, orthostatic hypotension, and heart rhythm disturbance. Other side effects reported include weight gain, vomiting, diarrhea, and sedation.Objective: To describe an 84-year-old woman who developed diabetes during treatment with clomipramine for depression.Case Report: The patient was admitted to our hospital in December 2006 because of polyuria, dehydration, and obtunded sensorium 5 months after starting treatment with clomipramine, 25 mg/d, to control depression ...References1. Scheen AJ, De Hert MA. Abnormal glucose metabolism in patients treated with antipsychotics. Diabetes Metab. 2007;33:169-75. [PMID: 17412628] CrossrefMedlineGoogle Scholar2. Henderson DC. Clozapine: diabetes mellitus, weight gain, and lipid abnormalities. J Clin Psychiatry. 2001;62 Suppl 23 39-44. [PMID: 11603884] MedlineGoogle Scholar3. Hampson LJ, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51. [PMID: 17579833] CrossrefMedlineGoogle Scholar4. Sugimoto Y, Inoue K, Yamada J. The tricyclic antidepressant clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003;93:74-9. [PMID: 14501155] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Ospedale Civile Livorno, 57100 Livorno, Italy.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes mellitus associated with clomipramine treatment: a retrospective analysisGlucose dysregulation associated with antidepressant agents: an analysis of 17 published case reportsDrug-Resistant Glioma: Treatment with Imatinib Mesylate and ChlorimipramineDrug-Induced DiabetesCurrent awareness: Pharmacoepidemiology and drug safety 21 October 2008Volume 149, Issue 8Page: 595-596KeywordsAntipsychoticsDrug therapyDrugsGlucoseHemoglobinHyperglycemiaInsulinUrineVomitingWeight gain ePublished: 21 October 2008 Issue Published: 21 October 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Conversion From FDG-Negative to -Positive During Follow-Up in a Rare Case of Pulmonary Lymphoepithelioma-Like Carcinoma
Authors: Daniel H. Y. Shen, Cheng-Yi Cheng, Li-Fan Lin, Hong-Wei Gao, Yueng-Long Cheng, Ching-Yuan Chen
Journal: Clinical Nuclear Medicine (2012)

A female patient aged 75 years presented with an incidental pulmonary nodule without FDG uptake when undergoing FDG PET/CT. Without obtaining histologic diagnosis, the follow-up FDG PET/CT 2 years later demonstrated intense FDG avidity within previously FDG-negative tumor. After surgery, the pathologic diagnosis is pulmonary lymphoepithelioma-like carcinoma (LELC). LELCs are unique because of histologic similarities with undifferentiated nasopharyngeal lymphoepithelioma and with a better prognosis as compared with other lung malignancies. However, the expression of FDG uptake in LELC has never been discussed. Herein, we describe a pulmonary LELC manifesting as a slowly growing tumor displaying conversion from FDG-negative to -positive avidity.
IDENTIFICATION DE PROTEINES HUMAINES DANS DES EXTRAITS ALLERGENIOUES DE POUSSIERES DE MAISON
Authors: R. Versie, J. Brocteur
Journal: Allergy (1967)

AllergyVolume 22, Issue 1 p. 11-27 IDENTIFICATION DE PROTEINES HUMAINES DANS DES EXTRAITS ALLERGENIOUES DE POUSSIERES DE MAISON R. VERSIE, R. VERSIE Université de Liège, Helgique. Laboratoire de Chimie Medicale, Toxicologie et Hygiène (Prof. C.IIeusghem); Lalviratoire des Ciroupes sanguins et de Transfusion, (Priif. P. Moureau). Chargée de Recherches du F. N. R. S.Search for more papers by this authorJ. BROCTEUR, J. BROCTEUR Université de Liège, Helgique. Laboratoire de Chimie Medicale, Toxicologie et Hygiène (Prof. C.IIeusghem); Lalviratoire des Ciroupes sanguins et de Transfusion, (Priif. P. Moureau).Search for more papers by this author R. VERSIE, R. VERSIE Université de Liège, Helgique. Laboratoire de Chimie Medicale, Toxicologie et Hygiène (Prof. C.IIeusghem); Lalviratoire des Ciroupes sanguins et de Transfusion, (Priif. P. Moureau). Chargée de Recherches du F. N. R. S.Search for more papers by this authorJ. BROCTEUR, J. BROCTEUR Université de Liège, Helgique. Laboratoire de Chimie Medicale, Toxicologie et Hygiène (Prof. C.IIeusghem); Lalviratoire des Ciroupes sanguins et de Transfusion, (Priif. P. Moureau).Search for more papers by this author First published: February 1967 https://doi.org/10.1111/j.1398-9995.1967.tb03186.xCitations: 7 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume22, Issue1February 1967Pages 11-27 RelatedInformation
Abstract 131: Biological effect of miR-210 overexpression on renal carcinoma cells
Authors: Chisato Nakada, Yoshiyuki Tsukamoto, Keiko Matsuura, Tung Lam Nguyen, Naoki Hijiya, Tomohisa Uchida, Fuminori Sato, Hiromitsu Mimata, Masao Seto, Masatsugu Moriyama
Journal: Cancer Research (2011)

Abstract MiR-210 is significantly upregulated in clear cell renal cell carcinoma (CCC), but the mechanism and biological consequences of miR-210 upregulation are poorly understood. Here, we show that miR-210 is highly expressed in renal carcinoma cell lines and that its expression is clearly correlated with accumulation of hypoxia inducible factor 1α (HIF1α) under normoxia as well as hypoxia, suggesting that miR-210 upregulation in renal carcinoma cells is most likely due to accumulation of HIF1α. To reveal the effects of miR-210 upregulation, the miR-210 precursor was transfected into renal carcinoma cells. After transfection, the cells accumulated at G2/M phase of the cell cycle and their viability was decreased, suggesting that miR-210 overexpression may trigger an event that hinders normal cell division. Immunocytochemistry demonstrated a multipolar spindle accompanied by centrosome amplification in cells overexpressing miR-210. It has been reported that centrosome amplification induces chromosome mis-segregation, finally leading to chromosome instability and aneuploidy. Indeed, the proportion of aneuploid cells (&amp;gt;4n) was increased in miR-210 overexpressed cells. By using the TargetScan and PicTar algorithms, E2F3 was identified as one of the possible targets of miR-210, and was suppressed at the protein level by miR-210. Moreover, the proportion of aneuploid cells was increased in E2F3 siRNA transfected cells. On the basis of these results, we propose that miR-210 upregulation due to HIF1α accumulation may induce aneuploidy via E2F3 downregulation at least in part, and may play a role in tumorigenesis and/or progression of CCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 131. doi:10.1158/1538-7445.AM2011-131
Clonal remission in aplastic anemia after treatment with antithymocyte globulin
Authors: Theodore Wun, Jerry P. Lewis
Journal: American Journal of Hematology (1992)

Abstract Aplastic anemia includes a group of disorders characterized by peripheral blood pancytopenia and marrow hypocellularity. The current report describes a patient who is an apparent constitutional mosaic and presented with marrow aplasia. Using cytogenetic analysis of bone marrow, skin, and peripheral T lymphocytes, we demonstrate the clonal nature of this patient's aplastic marrow, and, in addition, identify clonal evolution. The patient was treated with antithymocyte globulin (ATG) and achieved a complete remission, with disappearance of an abnormal evolved clone. This case illustrates that clonal cytogenetic abnormalities do not preclude a response to ATG and that aplastic anemia may be a nonmalignant clonal disorder with clonal evolution. © 1992 Wiley‐Liss, Inc.
Hydrogen peroxide as a protective agent during reperfusion A study in the isolated perfused rabbit heart subjected to regional ischemia
Authors: K. Ytrehus, R.S. Walsh, S.C. Richards, J.M. Downey
Journal: Cardiovascular Research (1995)

In spite of extensive research during the last decade it has not been possible to prove that endogenously generated hydrogen peroxide or any reduced oxygen species reaches sufficient concentration during reperfusion after myocardial ischemia to contribute significantly to irreversible cell injury. In an attempt to further test this hypothesis we subjected isolated perfused rabbit hearts to 30 min regional ischemia followed by reperfusion and supplied hydrogen peroxide in low levels with or without catalase during the first 30 min of reperfusion and thereafter continued the reperfusion for a total of 120 min. Five different groups were studied: controls, and hearts supplied with 2 microM H2O2, 1 microM H2O2, 1 microM H2O2 + catalase (IU/l) or catalase alone in the initial part of the reperfusion. At the end of 120 min reperfusion, area at risk was measured with fluorescent particles and infarct zone size with tetrazolium staining. The results were: in the control group 32 +/- 5.0% of the risk zone infarcted, in the 2 microM H2O2 group 16.3 +/- 5.6% and in the 1 microM H2O2 group 6.9 +/- 0.8% (P < 0.05 compared to control). The reduction in infarct size was not present when catalase was added to the hydrogen peroxide-containing solution (26.4 +/- 4.5) or if catalase was present alone (22.9 +/- 1.8% infarction). In conclusion, hydrogen peroxide, 1 microM, protected the heart during reperfusion and reduced the amount of cell death after 120 min of reperfusion. The study demonstrated reduction or delay in infarction based only on treatment in the reperfusion period. The mechanism behind this protection remains to be determined.