tbuckley/cabot-search huggingface dataset:
Digoxin Metabolism in Obesity
Authors: GORDON A. EWY, BERTRON M. GROVES, MICHAEL F. BALL, LANA NIMMO, BARBARA JACKSON, FRANK MARCUS
Journal: Circulation (1971)

A single intravenous dose of tritiated digoxin was given to five obese patients before and after a mean loss of 102 pounds in weight. There were no significant differences in the blood concentrations of digoxin before and after the weight reduction. Likewise, there were no significant differences in the blood concentrations of digoxin when these data were corrected for fat-free body weight. These findings are consistent with the thesis that fat-free body weight is a more important determinant of the blood concentration of digoxin than total body weight is. The clinical implication of this study is that digoxin dosage may be erroneously high if calculated on the basis of total body weight for obese individuals.
Is public support for environmental protection decreasing? An analysis of U.S. and New Jersey data.
Authors: Michael R Greenberg
Journal: Environmental Health Perspectives (2003)

Telephone surveys made of 800-1,000 randomly selected residents of the United States and New Jersey in 2003 show a sharp decline in support for antipollution regulations, although pollution remains a major concern. This drop in support is associated with slowing of the economy, fear of terrorism, and other competing priorities. The leading proponents of maintaining strong environmental regulations are relatively affluent mainstream white Americans. Despite this recent drop in support, overt attempts to weaken the basic regulations are likely to face stiff opposition unless there is an obvious economic downturn or increasing terrorism that causes a larger proportion of the public to feel that weakening environmental regulations will increase jobs and security. Key words: age, environmental laws and regulations, perception, polls, public support, race/ethnicity, trends.
The Physiology of Bone
Authors: Reginald R. Cooper
Journal: JAMA (1976)

Perhaps no book extant presents a comparably brief yet amazingly inclusive overview of bone physiology. Dame Vaughan skillfully extracted cogent facts and opinions from those currently available, superbly integrated them into a most readable form, and literally crammed this relatively small volume with valuable information. This collection of concepts, derived from a variety of disciplines, should dispel the too-long-held notion that bone acts merely as an inert, mechanical support for the body. Each chapter rightfully depicts bone as a highly dynamic structure fulfilling a critical role in multiple facets of body metabolism. Initial discussions of structure lucidly describe bone from the gross to ultrastructural level, comment on its blood supply, and present certain functional implications of structure. Experimental data serve to portray bone cells in terms of their functional roles in matrix synthesis and mineral metabolism. Discussions of bone matrix encompass collagen and protein polysaccharide structure, chemistry, synthesis, and disorders.
Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo
Authors: Rukhsana Aslam, Edwin R. Speck, Michael Kim, Andrew R. Crow, K. W. Annie Bang, Frederick P. Nestel, Heyu Ni, Alan H. Lazarus, John Freedman, John W. Semple
Journal: Blood (2005)
Abstract 677: Targeting the survivin splice variant 2β in taxane-resistant ovarian cancer
Authors: Pablo E. Vivas, Cristian Rodríguez-Aguayo, Hee-Dong Han, Mian M. Shahzad, Anil K. Sood, Gabriel Lopez-Berestein
Journal: Cancer Research (2010)

Abstract Survivin, a protein highly expressed in human cancers is involved in both control of cell cycle progression and inhibition of apoptosis. Transcription of the survivin gene locus (BIRC-5) yields at least 5 alternative splice variants that have been designed survivn-WT, survivin-ΔEx3, survivin-2β, surivivn-3β, and survivin 2α. It has been shown that the survivin splice variants have different expression levels and subcellular localization patterns that could be associated with unique functional properties. Whereas the effects of survivin on apoptosis and mitosis have been extensively studied and explored therapeutically, the role of specific survivin splice variants in ovarian cancer has not been investigated. Our compelling studies indicate that, compared with their taxane-sensitive counterparts, taxane-resistant ovarian cancer cells express higher survivin mRNA (particularly the WT, ΔEx3 and 2β isoforms) levels. Studies have shown that survivin-2β has proapoptotic properties: whereas, forced expression of survivin-2β sensitized cells to taxane-induced apoptosis, small-interference RNA (siRNA)-based silencing of survivin-2β protected cells from cells from apoptotic cell death. We have observed opposite results: siRNA-based silencing of survivin-2β induced cell growth arrest and apoptosis of taxane-resistant ovarian cancer cells. Furthermore, liposomes-encapsulated siRNA targeting survivin-2β inhibited tumor growth in orthotopic murine models of ovarian cancer. The anti-tumor effect was further increased by combination with docetaxel. Finally, we found a significant association of survivin-2β expression with progression free survival in the 117 epithelial ovarian cancers obtained at primary debulking therapy. Further studies are necessary to clarify the role of survivin-2β in ovarian cancer. The key finding from our study is that survive-2β is present in a substantial proportion of ovarian cancers, and is predictive of decreased progression-free survival (PFS) of ovarian cancer patients. These studies also show the feasibility of survivin-2β-targeting siRNA liposomal as a clinically applicable therapeutic modality for taxane-resistant ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 677.
Abstract 2219: STAT3 network dissection in ALK positive Anaplastic Large Cell Lymphomas
Authors: Elisa Spaccarotella, Aldi Pupuleku, Elisa Pellegrino, Cecilia Bandini, Manuela Ferracin, Daniela Cantarella, Andrea Rinaldi, Paolo Provero, Ferdinando D. Cunto, Enzo Medico, Francesco Bertoni, Giorgio Inghirami, Roberto Piva
Journal: Cancer Research (2014)

Abstract Anaplastic large cell lymphoma (ALCL) represents a category of T-cell Non-Hodgkin Lymphomas characterized by marked cellular pleomorphism, and expression of CD30. Two systemic forms of ALCL are defined by the presence or absence of chromosomal translocations involving the Anaplastic Lymphoma Kinase (ALK) gene at 2p23 locus. Among several pathways triggered by ALK signaling, it has been widely shown that the constitutive activation of STAT3 is strictly required for ALK-mediated transformation and survival. To discover essential mediators of STAT3 oncogenic activity that may represent feasible targets for ALCL therapies, we performed gene and miRNA expression profiling experiments in association with functional validation approaches. The transcriptome of STAT3 was analysed in ALK positive ALCL cell lines using a tightly controlled time course experimental condition, in which the STAT3 signalling was abrogated by an inducible short hairpin RNA (shRNA). Gene expression profiling analysis identified a selected number of genes (1730) specifically modulated by STAT3 silencing. A significant overrepresentation of putative STAT3 binding sites was found in regulatory regions of early down-regulated genes. Functional studies using a shRNA lentiviral library established that Interferon Regulatory Factor-4 (IRF4) targeting specifically affect cell viability of ALK+ ALCL cells. In contrast, forced expression of IRF4 partially rescued STAT3 knock-down sustaining the survival of ALK+ cells. In a parallel experiment, genome-wide miRNA expression profiling identified 48 miRNAs concordantly modulated by the inducible knock down of ALK and STAT3. Among these, we demonstrated that expression of miR-17∼92 cluster significantly reverted STAT3 deprivation, sustaining both proliferation and survival of ALCL cells. In conclusion, genes and miRNA expression profiling associated to functional screenings allowed the identification of new biologically relevant targets for ALK+ALCL. We speculate that IRF4 and miR-17∼92 cluster are involved in the lymphomagenesis of STAT3+ ALCL, and that their inhibition might represent an alternative avenue to interfere with ALK signaling in Anaplastic Large Cell Lymphomas. Citation Format: Elisa Spaccarotella, Aldi Pupuleku, Elisa Pellegrino, Cecilia Bandini, Manuela Ferracin, Daniela Cantarella, Andrea Rinaldi, Paolo Provero, Ferdinando Di Cunto, Enzo Medico, Francesco Bertoni, Giorgio Inghirami, Roberto Piva. STAT3 network dissection in ALK positive Anaplastic Large Cell Lymphomas. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2219. doi:10.1158/1538-7445.AM2014-2219
Progesterone Deficiency and Premature Labour
Authors: A. I. Csapo, O. Pohanka, H. L. Kaihola
Journal: BMJ (1974)

Plasma oestradiol 17beta and progesterone levels in 11 patients admitted to hospital for threatened premature labour of unknown aetiology were compared with those of women at similar stages of gestation whose pregnancy was normal. Oestradiol levels in the study group were slightly higher than in the normal controls but their progesterone levels were significantly lower. This progesterone deficiency increased the oestradiol/progesterone ratio in the study group patients, and it increased still more as the progesterone withdrawal continued during premature labour.Since uterine activity during pregnancy is regulated by a balanced action of several factors a deficiency in progesterone, an opponent of uterine activity, creates a regulatory imbalance which, if uncorrected, provokes premature labour. An increase in uterine volume stimulates uterine activity, and the present study reinforced our previous conclusion that the uterine-volume/plasma-progesterone ratio is a more accurate measure of the state of regulatory balance than the progesterone level alone.The cause of the progesterone deficiency in these cases remains unexplained, but we suggest that placental growth and function are contributory factors. We are investigating ways of correcting the resulting imbalance in the regulatory mechanism.
Delayed Age of Menarche of Athletes
Authors: Robert M. Malina
Journal: JAMA (1982)

<h3>To the Editor.—</h3> It is my fear that the conclusion of Frisch and colleagues (1981;246:1559), based on data that are derived from a small and seemingly unusual sample, may cause undue concern and worry by children, parents, and coaches. Indeed, the conclusion that training before menarche will delay menarche has been widely disseminated. There are thousands of premenarcheal girls engaged in sports training, and this questionable conclusion can have a negative impact on sports for girls. The conclusion is based on a small sample, 12 swimmers and six runners, who began training before menarche. Correlation analysis indicated a relationship between training before menarche and the age at menarche. It indicates only a relationship between the two variables, but does not indicate a cause-effect relationship. It could well have been that the young women took up training because of their delayed maturation rather than the training causing late maturation. If one
Human Malaria in Immunocompromised Mice
Authors: Edgar Badell, Claude Oeuvray, Alicia Moreno, Soe Soe, Nico van Rooijen, Ahmed Bouzidi, Pierre Druilhe
Journal: The Journal of Experimental Medicine (2000)

We have recently described that sustained Plasmodium falciparum growth could be obtained in immunodeficient mice. We now report the potential of this new mouse model by assaying the effect of the passive transfer of antibodies (Abs) which in humans have had a well-established effect. Our results show that the total African adult hyperimmune immunoglobulin Gs (HI-IgGs) strongly reduce P. falciparum parasitemia similarly to that reported in humans, but only when mice are concomitantly reconstituted with human monocytes (HuMNs). In contrast, neither HI-IgGs nor HuMNs alone had any direct effect upon parasitemia. We assessed the in vivo effect of epitope-specific human Abs affinity-purified on peptides derived either from the ring erythrocyte surface antigen (RESA) or the merozoite surface protein 3 (MSP3). The inoculation of low concentrations of anti-synthetic peptide from MSP3, but not of anti-RESA Abs, consistently suppressed P. falciparum in the presence of HuMNs. Parasitemia decrease was stronger and faster than that observed using HI-IgGs and as fast as that induced by chloroquine. Our observations demonstrate that this mouse model is of great value to evaluate the protective effect of different Abs with distinct specificity in the same animal, a step hardly accessible and therefore never performed before in humans.
Fritz Spiegl's MuSick Notes—A Medical Song Book
Authors: J S P Lumley
Journal: Journal of the Royal Society of Medicine (2002)

In his latest work, Fritz Spiegl has assembled the words and music of forty-two songs and other musical matter, all relating to medicine (it is about lotions, urges and purges). The cover of each piece has been reunited with its music, sometimes after more than a century. Twenty-six of these memorable illustrations have also been reproduced in full colour in a separate section.

The contents provide remedies for most of life's ailments, including Dr Jongh's Cod Liver Oil and Bile Beans. The Wincarnis Waltz demonstrates how medicine dealt with the problems of prohibition. Apparently, Beecham's pills were as good for bad legs as for headache and all nervous afflictions (as well as supporting Sir Thomas's orchestra), while Ja Jah protected against income tax as well as baldness. Spiegl's anecdotes and historical vignettes provide a characteristic blend of humour and education, updating the reader on phrenology, laughing gas, Burke and Hare, and the undertaker Bantry who first linked obesity with early death: we are reminded in the Lithotomy Sonata that Samuel Pepys was a rare survivor of such an intervention. We learn of heartache, heartbreak and the debauched medical student, and marvel at the potentials of thermogene and ipecacuanha in an era devoid of evidence-based practice, controlled trials or licensing laws. The more memorable tunes are often from the pen of distinguished composers. The music is well reproduced, although the three-quarter score occasionally requires magnification. None of the publishers is still in existence: there may be a message there somewhere.

Fritz Spiegl has provided an admirable collection of medical curios, giving us a glimpse of the music performed in Victorian and Edwardian parlours probably alongside the works of Gilbert and Sullivan and those of other more serious composers. The words and commentary offer plenty of opportunity for enjoyable browsing, and there is some good material to add to the performer's repertoire.
Abnormal lipid composition of chylomicrons in broad-β disease (type III hyperlipoproteinemia)
Authors: William R. Hazzard, Daniel Porte, Edwin L. Bierman
Journal: Journal of Clinical Investigation (1970)

Chylomicron (primary particles) were detected by polyvinylpyrollidone (PVP) flocculation in plasma collected after an overnight fast from eight hyperlipemic subjects with broad-β disease (type III hyperlipoproteinemia). The composition of these chylomicrons was abnormal: relatively poor in triglyceride and rich in cholesterol, giving rise to a triglyceride/cholesterol ratio of < 3.0 in all cases, uniformly below the ratio in chylomicrons from eight fasting subjects with mixed lipemia. By contrast, at the peak of alimentary lipemia following an oral fat load (2 g/kg), chylomicrons from broad-β subjects had normal, triglyceride-rich composition (triglyceride/cholesterol = 14.0) and resembled chylomicrons from subjects with mixed lipemia, endogenous lipemia, and familial hypercholesterolemia after similar fat loads. As the alimentary lipemia cleared, chylomicrons remaining in broad-β subjects 14-24 hr after the fat load were again rich in cholesterol. However, a similar degree of cholesterol enrichment was observed in chylomicrons from the subjects with familial hypercholesterolemia, while only a minor increase in cholesterol was recorded in chylomicrons from subjects with mixed or endogenous lipemia. Parallel studies of changes in chylomicron composition during in vitro incubation of whole plasma and of Sf > 400 with Sf < 400 lipoproteins from subjects with the different forms of hyperlipoproteinemia revealed equal cholesterol enrichment of chylomicrons from a subject with mixed lipemia and from a subject with broad-β disease in media of equivalent cholesterol content. These experiments suggested neither excessive avidity of chylomicrons for cholesterol uptake nor excessive influence of Sf < 400 lipoproteins upon chylomicron composition in broad-β disease.
Secrecy in Science: The Flock Worker's Lung Investigation
Authors: Miriam Shuchman
Journal: Annals of Internal Medicine (1998)

Currents15 August 1998Secrecy in Science: The Flock Worker's Lung InvestigationMiriam Shuchman, MDMiriam Shuchman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-4-199808150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Do scientists always have the right to present their findings in an open forum? Under what circumstances do they relinquish that right? When the public world of academia merges with the private world of industry, how does the notion of academic freedom apply?The Kern ControversyThese questions lie at the heart of a controversy that has pitted David Kern, MD, and his supporters against three institutions: Brown University Medical School in Providence, Rhode Island, where Kern is a faculty member; Memorial Hospital of Rhode Island (an affiliate of Brown University) in Pawtucket. Rhode Island, where Kern's occupational medicine unit ... Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByForbidden Knowledge: Public Controversy and the Production of Nonknowledge1Access to data and material for research: putting empirical evidence into perspectiveA Review of: “Miriam Shuchman. The Drug Trial: Nancy Olivieri and the Science Scandal that Rocked the Hospital for Sick Children ”Data Withholding and the Next Generation of Scientists: Results of a National SurveyParticipatory Action Research: A Protective Research DesignEthics and Skeptics: What Lies Behind Ethical Codes in Occupational HealthPatenting the sun: Enclosing the scientific commons and transforming the university?ethical concernsSuppression of Environmental SciencePatients’ health or company profits? The commercialisation of academic researchAttacks on Science: The Risks to Evidence-Based PolicyThe past and present of pneumoconiosesLa declaración del conflicto de intereses en las publicaciones científicas. ¿Tiempo para las luces y los taquígrafos en la trastienda de la investigación financiada por la industria?Update in Pulmonary DiseasesAshok M. Karnik, MD, FRCPNylon velouteringslong: chronische interstitiële longziektePersonal Reflections on Occupational Health in the Twentieth Century: Spiraling to the FutureFlock Worker's LungWilliam S. Beckett, MD, MPHFlock Worker's LungLawrence W. Raymond, MDSecrecy in Science: The Flock Worker's Lung InvestigationDavid G. Kern, MD, Robin K. Kern, JD, and Kate T.H. Durand, MHS, CIHPharmaceutical Industry Support of Psychiatric Research and Education: Ethical Issues and Proposed Remedies 15 August 1998Volume 129, Issue 4Page: 341-344KeywordsBloodDrugsHematology and oncologyInterstitial lung diseasesLungsMarshesPrevention, policy, and public healthRunningScientistsThyroxine Issue Published: 15 August 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Medical Library Association Guide to Managing Health Care Libraries
Authors: Nadia J. Lalla
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Child Psychology and Psychiatry
Authors: Marcia Slomowitz
Journal: JAMA (1997)

The journal<i>Clinical Child Psychology and Psychiatry</i>was established to provide a forum for articles relevant to clinicians who work with children and families. Published four times a year, it is intended to balance a perceived overemphasis on quantitative measurement. This peer-reviewed journal prefers qualitative research over quantitative research. The editor, the book review editor, and all associate editors are from London. Assessors on the panel are from the United States, Canada, the Netherlands, Japan, and Italy. These assessors represent the disciplines of child psychiatry, child psychology, pediatrics, social work, education, psychotherapy, nursing, ethics, sociology, and anthropology. No professional society sponsors this journal. Topics covered in the first three issues of the journal are timely and important, including child abuse, suicide, HIV and AIDS in children, and eating disorders.
Die Aortographie des Abdomens aus Klinischer Sicht
Authors: Edward A. Edwards
Journal: JAMA (1962)

This volume summarizes the various methods for aortography, with particular emphasis on the indirect or catheter method. The indications and contraindications for aortography are given considerable weight, and other roentgenologic techniques for studying the abdomen, either alone or in combination with aortography, are presented. There are numerous illustrations, 159, in a book of 199 pages. Variations and anomalies of the vessels, especially of the kidney, occupy a large portion of this book. What is particularly amazing, in the light of the American viewpoint, is that the emphasis is almost totally on extravascular disease, although, without a doubt, the techniques shown would also lend themselves to the delineation of intrinsic disorders of the vessels. Still, in a book which is half didactic and half atlas, one would expect more examples of vascular disease per se. While the book is a sound presentation of aortography, American readers may prefer the more comprehensive