tbuckley/cabot-search huggingface dataset:
Leg Scanning and Hip Surgery
Authors: Richard D. Sautter
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Regarding the article "Leg Scanning With RadioisotopeLabeled Fibrinogen in Patients Undergoing Hip Surgery: Comparison With Contrast Phlebography and Lung Scans" by LeMoine and Moser (1980;243:2035), the reference to my article<sup>1</sup>was appreciated; however, they misinterpreted our results, which seems to be a commonality of those who criticize our work. Their statement, "However, they included as 'false-negatives' 23 thrombi that were in the 'blind spot' and were, therefore, automatically destined to become false-negatives," is totally in error. None of the false-negatives reported were in the blind spot. Careful analysis of our data indicates that 14 false-negatives were found in the extremity operated on; however, leg scanning was performed only at points 4 and 5. Nine of the 23 false-negatives found in the anatomical area between Hunter's canal and the inguinal ligament were in the extremity that was not operated on. Furthermore, in the area between the popliteal
Abstract 3207: Monitoring changes in NF-kB pathway regulation using highly sensitive multiplex bioluminescent reporter assays
Authors: Megan Dobbs, Douglas Hughes, Janaki Narahari, Jae Choi, Atul Deshpande, Brian Webb
Journal: Cancer Research (2012)

Abstract Monitoring gene activation and repression in cellular signaling pathways requires specific tools. Reporter gene assays use a technique of attaching a genetic regulatory element, or promoter, to a gene encoding for a protein with enzymatic, chromophoric or fluorescent properties. Cloned into a plasmid vector, these sequences can be transfected or transduced into animal, plant or tissue culture cells. Reporter gene expression can be measured via bioluminescent, chemiluminescent or fluorescent output to quantify the element or protein activity in the pathway affecting the regulatory element. Bioluminescent output is formed through the catalysis of a substrate and the natural enzyme luciferase. Present in many terrestrial and marine metazoans, bioluminescence is a powerful instrument for mutational analysis of gene promoters, transcription factor dynamics, and protein-protein interactions. Our study confirmed the beneficial use of sensitive bioluminescent enzymes in reporter gene assays with wide dynamic ranges and flexibility in signal identification. Mutation of several of the luciferase genes resulted in spectral shifting and narrowing of the photon reaction products relative to the wavelength of the natural state. The mutations provide the ability to spectrally resolve the modified luciferases in a single reaction. In addition, multiplex assays relying on sequential addition of substrates can be achieved through manipulation of the enzyme-substrate reaction conditions. Marine copepod and ostracod luciferase enzymes are naturally secreted, and reporter assays using these genes can capture real-time or time course data by sampling the media of transfected cells or blood from transgenic animals and assaying for luciferase. The distinct advantage of these assays is that they are not destructive to the cells or animals. Our study used spectral separation using Gaussia/firefly and multiplex assays relying on sequential addition of substrates and Gaussia/Cypridina to monitor changes in NFkB activity in response to small-molecule agonists. Our results demonstrate the usefulness of dual-secreted luciferase assays for sensitive real-time monitoring of NFkB activity in media. Furthermore, these assays enable simultaneous detection of spectrally resolvable luciferases using filter-based detection. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3207. doi:1538-7445.AM2012-3207
STRUMA GELATINOSA—STRUMA COLLOIDES.
Authors: M. L. HARRIS
Journal: JAMA (1896)

Of the various pathologic changes which may occur in the thyroid gland, that of colloid formation is the most frequent. In order, however, that this colloid formation may receive the title of struma colloides it is not sufficient that a little colloid material be found in the vesicles or follicles throughout the gland as this is often a physiologic condition, especially in later life, but the colloid formation must occur in a circumscribed area or areas, sharply defined from the normal gland tissue and independently of it. Furthermore, as Wölfler states, there is in these cases an atypical new tissue formation, a budding of the gland tubules, so that what we really have is an adenoma, in the tubules of which the colloid material accumulates, leading to their distension: hence the name applied by Wölfler of adenoma gelatinosum. These new growths may be single or multiple, and when multiple may
Neonatal Thrombocytopenia Due to Passive Immunization
Authors: John G. Kelton, Victor S. Blanchette, William E. Wilson, Peter Powers, K. R. Mohan Pai, Sidney B. Effer, Ronald D. Barr
Journal: New England Journal of Medicine (1980)

PASSIVE immune neonatal thrombocytopenia is caused by the transplacental passage of platelet antibodies, either from a mother with autoimmune thrombocytopenia or from one who is alloimmunized by her infant's platelets.1 2 3 Usually, the transfer of autoantibodies from a mother with autoimmune disease is heralded by coexistent maternal thrombocytopenia, although in compensated thrombocytolytic states the maternal platelet count can be normal while the infant is thrombocytopenic.4 , 5 In contrast, neonatal thrombocytopenia due to transfer of alloantibodies (allo-NT) is associated with a normal maternal platelet count. Thus, the first sign of allo-NT can be extensive purpura at birth, occasionally accompanied by intracerebral hemorrhage that . . .
18F-FDG Retention Index and Biologic Prognostic Parameters in Breast Cancer
Authors: Ana María García Vicente, Ángel Soriano Castrejón, Fernanda Relea Calatayud, Azahara Palomar Muñoz, Antonio Alberto León Martín, Ignacio Chacón López-Muñiz, María del Mar Muñoz Sánchez, José Manuel Cordero García, Edward Mitsuro Becerra Nakayo
Journal: Clinical Nuclear Medicine (2012)

Aim: To analyze the correlation between [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) uptake assessed by positron emission tomography/computed tomography (PET/CT) in breast tumors and histopathologic and immunohistochemical prognostic factors. Material and Methods: Sixty-eight women with breast cancer were prospectively evaluated. PET/CT was requested in the initial staging previous to neoadjuvant chemotherapy (multicentric study). All the patients underwent a standard 18F-FDG PET/CT followed by a delayed acquisition, 1 hour (PET-1) and 3 hours (PET-2) after FDG administration. Both examinations were evaluated qualitatively and semiquantitatively (SUVmax values) in PET-1 (SUV-1) and in PET-2 (SUV-2). The percentage variation of the standard uptake values (retention index) between PET-1 and PET-2 was calculated. Clinical and metabolic stages were assessed according to TNM classification. All biologic prognostic parameters, such as the receptor status, p53 and c-erbB-2 expression, proliferation rate (Ki-67), and grading were determined from tissue of the primary tumor. Metabolic, clinical, and biologic parameters were correlated. Results: A positive relationship was found between the SUVmax, tumor size, clinical, and metabolic stages. SUV-1 and SUV-2 values showed significant statistical correlation (P < 0.05) with PET stage and tumor size assessed by PET. On the contrary, the retention index showed relation with clinical stage (P < 0.05). When related to the biologic parameters, retention index showed the best results, with positive and significant relation (P < 0.05), with histologic grade, and Ki-67 and c-erbB-2 expression. Isolated SUV values only showed significant relation to Ki-67 expression. Conclusion: The retention index showed the best relation with biologic and clinical parameters compared with isolated SUVmax values for what could be a predictive marker of tumor biologic behavior.
Low phospholipid arachidonic acid values in diabetic platelets.
Authors: D B Jones, R D Carter, B Haitas, J I Mann
Journal: BMJ (1983)

Platelet aggregation is enhanced in diabetes mellitus, and platelets may be implicated in the pathogenesis of diabetic angiopathy. Increased platelet aggregation is probably mediated by the production of the proaggregatory prostaglandin thromboxane, which is synthesised from arachidonic acid (C20:4) by the action of the platelet enzymes cyclo-oxygenase and thromboxane synthetase. The fatty acid composition of platelet phospholipid was measured in 20 normal controls, 10 insulin-treated diabetics with no or minimal retinopathy, and 10 insulin-treated diabetics with proliferative retinopathy. The percentage of arachidonic acid was significantly higher in controls (mean 22.6%) than in the diabetics with no or minimal retinopathy (mean 18.5%; p less than 0.025) and the diabetics with proliferative retinopathy (mean 14.6%; p less than 0.001). The percentage of linoleic acid was lower in controls (mean 8.9%) than in the diabetics with no or minimal retinopathy (mean 12.6%; p less than 0.01) and diabetics with proliferative retinopathy (mean 13.1%; p less than 0.001). The mean percentage of linolenic acid was significantly lower in the diabetics with proliferative retinopathy (2.7%) than in the normal control group (4.4%; p less than 0.01). A significant negative correlation was found between the percentages of arachidonic acid and glycosylated haemoglobin (Rs = -0.58; p less than 0.001). A significant positive correlation was found between linoleic acid and the percentage of glycosylated haemoglobin (Rs = 0.51; p less than 0.01). The reciprocal correlation between percentages of arachidonic acid and glycosylated haemoglobin suggests that diabetic control may influence thromboxane release and platelet activity directly and that low percentages of arachidonic acid reflect the increased degree of in-vivo activation.
GLOBAL LONGITUDINAL STRAIN MEASURED FROM REST ECHOCARDIOGRAPHY IMAGES HAS COMPARABLE DIAGNOSTIC ACCURACY AS STRESS INDUCED WALL MOTION SCORE INDEX IN DETECTING SIGNIFICANT CORONARY ARTERY DISEASE
Authors: Kofo O. Ogunyankin, Jyothy J. Puthumana, Shelley L. Sarson
Journal: Journal of the American College of Cardiology (2010)
Long-term results of catheter ablation of a posteroseptal accessory atrioventricular connection in 48 patients.
Authors: F Morady, M M Scheinman, W H Kou, J C Griffin, M Dick, J Herre, A H Kadish, J Langberg
Journal: Circulation (1989)

Forty-eight patients with a posteroseptal accessory atrioventricular (AV) connection underwent catheter ablation of the accessory AV connection with 200-400 J shocks delivered by a standard defibrillator. Cathodal shocks were delivered through the proximal pair of electrodes of a 6F quadripolar electrode catheter positioned in the coronary sinus such that the proximal electrodes straddled the ostium (12 patients) or the third electrode from the tip was at the ostium (36 patients). A 16-cm patch electrode positioned on the back or anterior chest served as the anode. Two to 4 shocks were delivered (total, 635 +/- 198 J, mean +/- SD). The cathether ablation procedure was clinically successful in eliminating symptomatic tachycardias in in 32 of 48 patients (67%) during a mean follow-up of 26 +/- 19 months. A long-term follow-up electrophysiology study was performed in 27 of the 32 patients who had a successful clinical outcome, and this showed that conduction through the accessory AV connection was completely absent in 25 patients and present but impaired in two patients. The success rate was significantly higher in patients with a concealed accessory AV connection (13 of 13, 100%) than in patients with manifest preexcitation (19 of 35, 54%; p less than 0.001). Among the 12 patients in whom the proximal electrodes of the ablation catheter straddled the ostium of the coronary sinus, one patient developed cardiac tamponade requiring needle pericardiocentesis; there were no instances of cardiac tamponade among the 36 patients in whom the third electrode from the tip was at the ostium of the coronary sinus. Other complications were AV block requiring a permanent pacemaker and transient atrial tachycardia in one patient each and an asymptomatic pericardial effusion in three patients. In conclusion, with the catheter ablation technique described in this study, a successful clinical outcome may be achieved in approximately two thirds of patients who have a posteroseptal accessory AV connection, and the risk of serious complications is low. This technique is particularly well suited to patients with a concealed posteroseptal accessory AV connection, in whom the success rate is higher than in patients with manifest preexcitation.
CAFFEINE AND THE QUESTION OF ITS ISOMERISM.Read in the Section of Materia Medica and Pharmacy, at the Forty-third Annual Meeting of the American Medical Association, held at Detroit. Mich.. June, 1892.
Authors: ALBERT B. PRESCOTT
Journal: JAMA (1893)

In chemistry, caffeine is a body of distinctive molecular character, the subject of active research within the past ten years. In physiology it is bound to be of increasing interest that caffeine, the chosen adjunct of food, holds a remarkable relation to uric acid, an excretory carrier of nitrogen. In dietetics it is of wide import that the beverage plants of the world owe their effects in great measure to caffeines. In pharmacognosy it is worthy of attention that uncertain combinations of caffeines are in medicinal use. In these several studies it is desirable to settle the chemical question, whether caffeine be capable of isomerism or not. This is not a question that has been raised by chemists; nor is there at present any chemical evidence, that I am aware of, for so much as a suggestion of the isomerism of caffeine. Pharmacologists have virtually raised this question, though they
Relation of bronchioloalveolar carcinoma to tobacco.
Authors: A. Morabia, E. L. Wynder
Journal: BMJ (1992)

To determine whether bronchioalveolar carcinoma is related to tobacco use.Case-control study.11 teaching hospitals of Chicago, Long Island, New York, and Philadelphia, 1977-89.87 patients with histologically diagnosed bronchioloalveolar carcinoma (cases) and 286 non-cancer and 297 cancer patients matched to cases on age, sex, race, hospital, and date of admission.10% of male cases and 25% of female cases had never smoked. Relative risks of bronchioloalveolar carcinoma (as estimated by the relative odds) were greater for subjects who started smoking at a younger age, smoked for a longer time, or smoked more cigarettes per day. Relative risks decreased proportionally to the duration of smoking cessation.Smoking plays an important part in the aetiology of bronchioloalveolar carcinoma but is not the only potential cause because of the large proportion of never smokers among patients with this disease.
Permanent Oviduct Posteriorization after Neonatal Exposure to the Phytoestrogen Genistein
Authors: Wendy N. Jefferson, Elizabeth Padilla-Banks, Jazma Y. Phelps, Kevin E. Gerrish, Carmen J. Williams
Journal: Environmental Health Perspectives (2011)

Preimplantation embryo loss during oviduct transit has been observed in adult mice after a 5-day neonatal exposure to the phytoestrogen genistein (Gen; 50 mg/kg/day).We investigated the mechanisms underlying the contribution of the oviduct to infertility.Female mice were treated on postnatal days 1-5 with corn oil or Gen (50 mg/kg/day). We compared morphology, gene expression, and protein expression in different regions of the reproductive tracts of Gen-treated mice with those of control littermates at several time points.Neonatal Gen treatment resulted in substantial changes in expression of genes that modulate neonatal oviduct morphogenesis, including Hoxa (homeobox A cluster), Wnt (wingless-related MMTV integration site), and hedgehog signaling genes. An estrogen receptor antagonist blocked these effects, indicating that they were induced by the estrogenic activity of Gen. Oviducts of adults treated neonatally with Gen had abnormal morphology and were stably "posteriorized," as indicated by altered Hoxa gene patterning during the time of treatment and dramatic, permanent up-regulation of homeobox genes (e.g., Pitx1, Six1) normally expressed only in the cervix and vagina.Neonatal exposure to estrogenic environmental chemicals permanently disrupts oviduct morphogenesis and adult gene expression patterns, and these changes likely contribute to the infertility phenotype.
Interdialytic weight gain and survival in hemodialysis patients: Effects of duration of ESRD and diabetes mellitus
Authors: Paul L. Kimmel, Maria P. Varela, Rolf A. Peterson, Karen L. Weihs, Samuel J. Simmens, Sylvan Alleyne, Amali Amarashinge, Gary J. Mishkin, Illuminado Cruz, Judith H. Veis
Journal: Kidney International (2000)
New Orleans, Katrina, and the Death and Life of Cities
Authors: Robert M. Golub
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib
Authors: Douglas D. Fang, Bin Zhang, Qingyang Gu, Maruja Lira, Qiang Xu, Hongye Sun, Maoxiang Qian, Weiqi Sheng, Mark Ozeck, Zhenxiong Wang, Cathy Zhang, Xinsheng Chen, Kevin X. Chen, Jian Li, Shu-Hui Chen, James Christensen, Mao Mao, Chi-Chung Chan
Journal: Journal of Thoracic Oncology (2014)
Are cardiovascular reflexes more commonly impaired in patients with bronchial carcinoma?
Authors: G A Gould, M Ashworth, G T Lewis
Journal: Thorax (1986)

Non-invasive tests of cardiovascular autonomic function were performed in 69 patients with histologically proved bronchial carcinoma and the results compared with those obtained in a group of age and sex matched controls. Only two patients were under 50 years of age, and with the exception of the heart rate response to deep breathing the tests performed have no accepted normal ranges in patients of this age. None of the patients had features of florid, disabling autonomic neuropathy. All the tests of autonomic function showed declining performance with age but in addition there were significant differences in the results when the two groups were compared. In the group with carcinoma the resting heart rate was higher (p less than 0.05), the resting supine blood pressure lower (p less than 0.01), and the postural fall in blood pressure greater (p less than 0.01). Test results were not related to tumour histology, the presence of finger clubbing, drug history, or symptoms suggestive of autonomic dysfunction. Abnormal responses in tests of cardiovascular autonomic function are commonly found in elderly patients but bronchial carcinoma appears to have an additional effect. The precise mechanism of this effect remains a matter for speculation.
TCT-540 Trends in Hospital Treatments for Peripheral Arterial Disease in the United States and Impact of Payer Status on Quality of Care and Outcomes, 2007-2011
Authors: Luke Kim, Rajesh V. Swaminathan, Robert Minutello, Christopher Gade, S. Chiu Wong, Geoffrey Bergman, Harsimran S. Singh, David Yang, Konstantinos Charitakis, Ashish Shah, Ryan K. Kaple, Dmitriy Feldman
Journal: Journal of the American College of Cardiology (2014)
Synergistic Effect Of Dermatophagoides Pteronyssinus Allergens and Dexamethasone On Expression Of CD163 By Peripheral Blood Mononuclear Cells Of Allergic Asthma Patients
Authors: Krzysztof Kowal, Pawel Bernatowicz, Lech Chyczewski, Anna Bodzenta-Lukaszyk
Journal: Journal of Allergy and Clinical Immunology (2014)
The drug industry is a barrier to diabetes care in poor countries
Authors: J. S. Yudkin
Journal: BMJ (2012)

In many parts of the world, people with type 1 diabetes (whether or not the condition is diagnosed) still die for want of insulin, and those with type 2 diabetes go without treatments that prolong life at minimal cost—metformin, antihypertensives, and statins.1 The UN High-level Meeting on Non-communicable Diseases (NCDs) in New York in 2011 emphasised the importance of accessibility to and affordability of effective treatment, but concerns have been expressed that including the food, tobacco, and pharmaceutical industries in deliberations could undermine the development of sound policy.2 There was a vital role for novel patented medicines to tackle HIV/AIDS a decade ago, but it is questionable whether the same applies to management of NCDs. 

I argue that the approaches to management that are so heavily advocated by the research based drug industry are not just irrelevant to diabetes care in low income countries, but are actually counterproductive. 

One of the important needs addressed by the UN meeting was ensuring universal access to affordable high quality essential medicines for NCDs. All four diabetes drugs on the 2011 WHO essential medicines list,3 and those recommended as first line agents by the National Institute for Health and Clinical Excellence,4 are available at low cost from generic manufacturers. A decade ago, tackling World Trade Organization agreements on intellectual property was integral to improving the global availability and affordability of antiretroviral drugs, but drugs still under patent protection are unnecessary for …
Aryl hydrocarbon receptor controls murine mast cell homeostasis
Authors: Yufeng Zhou, Hui-Ying Tung, Ying-Ming Tsai, Shih-Chang Hsu, Hui-Wen Chang, Hirokazu Kawasaki, Hsiao-Chun Tseng, Beverly Plunkett, Peisong Gao, Chih-Hsing Hung, Becky M. Vonakis, Shau-Ku Huang
Journal: Blood (2013)
A Patient With Systolic Dysfunction and an Alternating Axis
Authors: P. Elliott Miller, Eric L. Scholten, Chintan S. Desai, Ryan J. Tedford
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal