tbuckley/cabot-search huggingface dataset:
Transient Wolff-Parkinson-White Syndrome and Neonatal Reciprocating Tachycardia
Authors: RUDOLF J. MOENE, JAN P. ROOS
Journal: Circulation (1973)

A premature infant is reported with a transient Wolff-Parkinson-White (WPW) Syndrome, atrial reciprocating rhythm and atrial reciprocating tachycardia during the second month of life. The spontaneous onset and termination of numerous attacks of tachycardia were recorded and analyzed. Many electrocardiographic tracings suggested the presence of Wenckebach periodicity of the anomalous A-V pathway resulting in atrial reciprocal rhythm which from time to time initiated a reciprocating tachycardia. In some tracings atrial reciprocal rhythm was preceded by a wandering atrial pacemaker. The presented electrocardiographic tracings emphasize the significance of reciprocal rhythm in the genesis of paroxysmal tachycardia in infants with a transient WPW Syndrome. At the end of the second month of life the attacks of tachycardia stopped, and the electrocardiogram became normal and remained so during a total follow-up period of ten months.
Response to Letter Regarding Article “Sleep and Exertional Periodic Breathing in Chronic Heart Failure: Prognostic Importance and Interdependence”
Authors: Ugo Corrà, Massimo Pistono, Alessandro Mezzani, Alberto Braghiroli, Enzo Bosimini, Marco Gnemmi, Pantaleo Giannuzzi, Andrea Giordano, Paolo Lanfranchi
Journal: Circulation (2006)
Complications in Anesthesiology
Authors: Alex Macario
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unrecognized chronic hepatitis C virus infection among baby boomers in the emergency department
Authors: James W. Galbraith, Ricardo A. Franco, John P. Donnelly, Joel B. Rodgers, Jordan M. Morgan, Andres F. Viles, Edgar T. Overton, Michael S. Saag, Henry E. Wang
Journal: Hepatology (2014)

The Centers for Disease Control and Prevention and U.S. Preventive Services Task Force have highlighted public screening as an essential strategy for increasing hepatitis C virus (HCV) detection in persons born between 1945 and 1965 ("baby boomers"). Because earlier HCV screening efforts have not targeted emergency department (ED) baby boomer patients, we describe early experience with integrated opt-out HCV antibody (Ab) screening of medically stable baby boomers presenting to an urban academic ED. We performed HCV Ab testing 24 hours per day and confirmed positive test results using polymerase chain reaction (PCR). The primary outcome was prevalence of unrecognized HCV infection. Among 2,325 unique HCV-unaware baby boomers, 289 (12.7%) opted out of HCV screening. We performed HCV Ab tests on 1,529 individuals, of which 170 (11.1%) were reactive. Among Ab reactive cases, follow-up PCR was performed on 150 (88.2%), of which 102 (68.0%) were confirmed RNA positive. HCV Ab reactivity was more likely in males compared to females (14.7% vs. 7.4%; P<0.001), African Americans compared to whites (13.3% vs. 8.8%; P=0.010), and underinsured/ uninsured patients compared to insured patients (16.8%/16.9% vs. 5.0%; P=0.001). Linkage-to-care service activities were recorded for 100 of the 102 confirmed cases. Overall, 54 (54%) RNA-positive individuals were successfully contacted by phone within five call-back attempts. We confirmed initial follow-up appointments for 38 (70.4%) RNA-positive individuals successfully contacted, and 21 (55.3%) individuals with confirmed appointments attended their initial visit with a liver specialist; 3 (7.9%) are awaiting an upcoming scheduled appointment.We observed high prevalence of unrecognized chronic HCV infection in this series of baby boomers presenting to the ED, highlighting the ED as an important venue for high-impact HCV screening and linkage to care.
Early pregnancy assessment units.
Authors: A J Dawson, D R Cohen
Journal: BMJ (1991)

that an intrauterine contraceptive device may be inserted only up to five days after unprotected intercourse will restrict unnecessarily the use of this highly effective postcoital method.It is accepted clinical practice to fit the device up to five days after the calculated earliest date ofovulation.2In emergencies where coital exposure took place more than five days previously, the shortest cycle length ever experienced by the woman must be ascertained and the day of ovulation calculated.An intrauterine contraceptive device can then be fitted up to five days after the earliest calculated date of ovulation.In a normal 28 day cycle this extends the time allowed for use of the device to day 19 of the cycle.This is of particular relevance when multiple exposures have occurred.
Transcutaneous measurement of blood flow velocity in the human aorta
Authors: B. A. J. ANGELSEN, A. O. BRUBAKK
Journal: Cardiovascular Research (1976)

A Doppler velocity meter for measuring blood flow velocity in the human aorta is described. Using pulsed ultrasound, this instrument allows the velocity to be measured at selected depths. The instrument has been tested in laboratory experiments, and appears to give accurate estimates of mean flow velocity for both steady and pulsatile flows. Flow velocities and estimates of stroke volume have been obtained from the ascending aorta in 18 patients. It is suggested that at present only relative values for flow and flow velocity can be measured. A method for obtaining absolute values for these parameters, based on scanning in the aortic arch, is proposed.
Encore fin de siecle.
Authors: M. Neve
Journal: BMJ (1989)

managers have not benefited as much as their private sector counterparts from the widening national spectrum ofearnings.This is at the very time that the radical reorganisation of public services requires that top quality managers are hired - and kept-to handle the changes. Job securityUntil recently public servants could at least console themselves that in terms of non-monetary remuneration they could make up some lost ground with the private sector."Job security" was a key element-but one that has been undermined by privatisation, competitive tendering, and individual employment contracts based on performance.Other benefits may also be diluted.If self governing hospitals choose to adopt non-Whitley regulations employees will face less favourable terms ofemployment legislation on issues such as sick pay.Even their lead on less work for less pay is being eroded as private sector employees are given increasing amounts of holiday.And if regionally differentiated pay is introduced the safety net of national wage rates will be removed from those in the lower wage sectors.Yet not all public employees are in the same boat.Police, firemen, and nurses have received annual increases well above the public sector average thanks to index linked formulas and a review body.The trade off is clear: higher pay and no strikes.So why not offer such alternatives to collective bargaining to ambulance staff and other workers in the public sector?The government's summer enthusiasm for banning public sector strikes, particularly in emergency services, seems to have waned: it would cost the Treasury money.Review bodies cannot provide a total panacea-they cannot handle working practices -but they do take careful account of recruitment and motivation, ensuring decent treatment for public employees without recourse to strike action.It is not only the police and nurses who need a fair deal.
Influence of Saline, Papaverine, Nitroglycerin and Ethyl Alcohol on Electrocardiographic Response to Standard Exercise in Coronary Disease
Authors: HENRY I. RUSSEK, RICHARD H. SMITH, WILLIAM S. BAUM, CHARLES F. NAEGELE, FREDERIC D. REGAN
Journal: Circulation (1950)

Much disagreement exists regarding the value of vasodilator agents in the treatment of coronary disease. Opinions have largely been based upon observations of pharmacologic action of drugs in animals, uncontrolled clinical studies and analyses of a purely subjective index, that of pain, in patients with angina pectoris. A technic was devised, therefore, to study the modifying action of various drugs upon the electrocardiographic response to standard exercise. To have validity, the procedure could be carried out only in a patient showing constant electrocardiographic changes with each performance of the standard test. The present communication records the findings in such a patient who was studied in this manner.
Abstract 5690: Validating sigma-2 receptor ligand as a novel tumor-targeted drug delivery agent for treating ovarian cancer
Authors: Chenbo Zeng, Suwanna Vangveravong, Justin M. Rothfuss, Jinbin Xu, Robert H. Mach
Journal: Cancer Research (2012)

Abstract The sigma-2 receptor is overexpressed in various human tumors. Sigma-2 receptor selective radiotracers have been shown to target various solid tumors in rodents and in human patients using positron emission tomography. Sigma-2 receptor ligands can be internalized into tumor cells by the endocytotic pathway. Therefore, sigma-2 receptor ligands are excellent candidates as tumor-targeted delivery agents when covalently attached to drugs. Smac is a protein released from mitochondria into the cytosol in response to apoptotic stimuli. Small-molecule Smac mimetic compounds (SMC) have been developed by several laboratories as anticancer drugs. In this study we validate sigma-2 ligand as a tumor-targeting drug delivery agent for treating ovarian cancer. We have synthesized sigma-2 ligand-conjugated SMC (SSMC), SW III-123. Our data show that SW III-123 has adequate sigma-2 receptor binding affinities (Kiα2 =190 nM and Kiα1 =2046 nM). SW III-123 exhibits potent antitumor activities with EC50 values at 4.0 μM, 2.3 μM and 2.4 μM in human ovarian cancer cell lines SKOV-3, CaOV-3, and BG-1, respectively. In contrast, unconjugated SMC, SW IV-52s, shows little cytotoxicity in these cell lines (EC50 &amp;gt; 200 μM). These results suggest that the sigma-2 ligand has successfully delivered SMC into ovarian cancer cells. Western blot results show that SW III-123 degrades inhibitor of apoptosis proteins (IAPs), XIAP and cIAP-1, in SKOV-3 cells, possibly by interacting with the baculovirus IAP repeat (BIR) domains of IAPs. SW III-123 cleaves caspase-3, 8, and 9 dose-dependently in SKOV-3 cells, indicating that SW III-123 kills ovarian cancer cells by activating both intrinsic and extrinsic apoptotic pathways. In conclusion, sigma-2 ligand is a promising tumor-targeting drug delivery agent. SSMC will likely offer a novel class of therapeutic drugs for treating ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5690. doi:1538-7445.AM2012-5690
Molecular characterization of hemoglobin C in sicily
Authors: M. Travi, L. Cremonesi, P. Primignani, S. di Benedetto, R. Testa, G. Schilirò, M. Ferrari
Journal: American Journal of Hematology (1992)

Analysis of polymorphisms of the beta-globin gene cluster was performed on 12 families and on one unrelated individual of Sicilian origin who carried hemoglobin C (Hb C). Two different haplotypes were found in association with beta c Sicilian alleles, corresponding to haplotypes I and II previously described in American blacks. In our population, the more frequent one (haplotype I) was linked to the lack of a polymorphic HpaI site 3' to the beta gene (13.0-kb fragment), similarly to haplotype I in blacks, while the less frequent one was linked to a 7.0-kb HpaI fragment attributable to a site that had never been previously described in linkage with beta c alleles. In Italy, these two haplotypes have been found in rare cases in association with beta A alleles. These findings provide new insights into the origin of Hb C present in Sicily, suggesting that (1) the beta c mutation detected in Sicily derived from African black chromosomes and does not represent a new mutation; and (2) Hb C may have originated either by multiple mutational events on separate chromosomes or by mutation in the HpaI site 3' to the beta gene in a pre-existing beta c chromosome.
Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates
Authors: Ivona Pandrea, Elaine Cornell, Cara Wilson, Ruy M. Ribeiro, Dongzhu Ma, Jan Kristoff, Cuiling Xu, George S. Haret-Richter, Anita Trichel, Cristian Apetrei, Alan Landay, Russell Tracy
Journal: Blood (2012)
A phase 1/2 trial of HQK‐1001, an oral fetal globin inducer, in sickle cell disease
Authors: Abdullah Kutlar, Kenneth Ataga, Marvin Reid, Elliott P. Vichinsky, Lynne Neumayr, Loray Blair‐Britt, Richard Labotka, Jonathan Glass, Jeffrey R. Keefer, William A. Wargin, Ronald Berenson, Susan P. Perrine
Journal: American Journal of Hematology (2012)

Abstract Therapeutics which reduce the pathology in sickle cell syndromes are needed, particularly noncytotoxic therapeutics. Fetal hemoglobin (HbF, α 2 γ 2 ) is established as a major regulator of disease severity; increased HbF levels correlate with milder clinical courses and improved survival. Accordingly, sodium dimethylbutyrate (HQK‐1001), an orally‐bioavailable, promoter‐targeted fetal globin gene‐inducing agent, was evaluated in a randomized, blinded, dose‐ranging Phase I/II trial in 24 adult patients with HbSS or S/β thalassemia, to determine safety and tolerability of three escalating dose levels. The study therapeutic was administered once daily for two 6‐week cycles, with a two‐week interim dose holiday. Twenty‐one patients completed the study. Five patients received study drug at 10 or 20 mg/kg doses, seven patients received study drug at 30 mg/kg/dose, and 4 patients received placebo. HQK‐1001 was well‐tolerated with no unexpected drug‐related adverse events; a dose‐limiting toxicity was not identified. Plasma drug levels were sustained above targeted levels for 24 hr. Increases in HbF above baseline were observed particularly with 30 mg/kg/day doses; in five of seven treated patients, a mean absolute increase in HbF of 0.2 g/dl and a mean increase in total hemoglobin (Hgb) of 0.83 g/dl above baseline were observed, whereas no increases occurred in placebo‐treated controls. These findings of favorable PK profiles, tolerability, early rises in HbF, and total Hgb indicate that trials of longer duration appear warranted to more definitively evaluate the therapeutic potential of HQK‐1001 in sickle cell disease. Am. J. Hematol., 2012. © 2012 Wiley Periodicals, Inc.
Six-month clinical and angiographic outcome after successful excimer laser angioplasty for in-stent restenosis
Authors: Ralf Köster, Jan Kähler, Wolfram Terres, Jacobus Reimers, Stephan Baldus, Dirk Hartig, Jürgen Berger, Thomas Meinertz, Christian W Hamm
Journal: Journal of the American College of Cardiology (2000)
Klinefelter's Syndrome and Benign Prostatic Hypertrophy
Authors: Harry C. Miller
Journal: JAMA (1963)

A patient is described who presented initially with benign prostatic hypertrophy and urinary retention. He underwent a prostatectomy and subsequent bilateral orchiectomy for microscopic "carcinoma of the prostate." Leydig cell hyperplasia was found on pathologic examination of the testes and evaluation for Klinefelter's syndrome was initiated. He was studied with buccal smears, polymorphonuclear leukocyte examinations, hormone excretion titers, short-term leukocyte tissue cultures with chromosome analyses, and, finally, by autopsy. He was proved to have Klinefelter's syndrome, benign prostatic hypertrophy, and, at autopsy, malignant carcinoid with widespread metastases; he did<i>not</i>have carcinoma of the prostate. The occurrence of this case raises many questions about the hormonal make-up of the Klinefelter's patient, about the stimulus for development of benign prostatic hypertrophy, and about the coincidental occurrence of solid tumors and chromosomal anomalies.
ROLE: A CONCEPT LINKING SOCIETY AND PERSONALITY
Authors: WILLIAM F. KNOFF
Journal: American Journal of Psychiatry (1961)

The concept of role is considered to be a focal concept derived in the scientific study of social life to which social scientists and psychiatrists are increasingly turning their attention. A brief review of the development of this concept has been presented and attention called to its possible integrative function in the study of sociological and psychological phenomena. Some implications and applications of role theory are briefly discussed.
Oral Antihyperglycemic Therapy for Type 2 Diabetes
Authors: Silvio E. Inzucchi
Journal: JAMA (2002)

Diabetes mellitus affects more than 6% of the US population, with the great majority having type 2 diabetes mellitus (DM). 1 In some older groups, the prevalence of DM and its metabolic forerunner, impaired glucose tolerance (IGT), approaches 25%. 2 Throughout the past decade, a 30% increase in the prevalence of DM has been recorded in the United States, with the most dramatic increases in younger individuals. 3When the long-term complications of this disease and their costs are considered, the implications of these statistics are sobering. 46][7] Whether such a relationship exists for macrovascular complications, such as myocardial infarction and stroke, is less clear. 7Simultaneously, a rapidly expanding therapeutic armamentarium is now available to treat hyperglycemia in type 2 DM.The number of oral antihyperglycemic agent classes, each with its unique mechanism of action, has increased 5-fold throughout the past 6 years-an often confusing increase in new categories of drugs: biguanides, ␣-glucosidase inhibitors, thiazolidinediones (TZDs), and nonsulfonylurea insulin secretagogues.More therapeutic options translate into more complex decision making for primary care physicians and diabetic pa-tients.In this article I review the individual oral-agent drug classes and the published evidence demonstrating their
It may not be intestinal, but tissue non-specific alkaline phosphatase
Authors: O. Martinez-Augustin, R. Lopez-Posadas, R. Gonzalez, I. Ballester, M. D. Suarez, A. Zarzuelo, F. Sanchez de Medina
Journal: Gut (2010)

The interesting study by Tuin et al 1 in a recent issue of Gut uncovers a hitherto unrecognised protective role of alkaline phosphatase (AP) in intestinal inflammation. These authors measured AP activity (including lipopolysaccharide (LPS) as a substrate) and mRNA level of the intestinal isoform (IAP) in inflamed and non-inflamed mucosa of patients with inflammatory bowel disease. IAP expression and AP activity were virtually non-existent in the colon when compared to the ileum.

These researchers follow up on a recent paper by Richard Hodin's group2 which describes …
EVALUATION OF A SPECIFIC ANTIDOTE TO DABIGATRAN: IN VITRO PROPERTIES, PHARMACOKINETICS AND REVERSAL OF DABIGATRAN ETEXILATE–INDUCED BLEEDING IN RATS
Authors: Joanne van Ryn, Tobias Litzenburger, Guanfa Gan, Kelly Coble, Johanna Schurer
Journal: Journal of the American College of Cardiology (2013)
Strokes and hypertension: contribution of poor blood pressure control.
Authors: P G Kennedy, B I Hoffbrand
Journal: BMJ (1978)

found any other reports of pneumomediastinum as a complication of anorexia nervosa, starvation, or wasting diseases.Studies on rats of lung ultrastructure and mechanics after prolonged starvation have shown an increase in alveolar surface forces and a decrease in tissue elasticity, with fewer lamellar bodies in pulmonary granular pneumo- cytes (the storage site for surfactant) and a decrease in volume density of mitochondria in the same cells.3Perhaps comparable changes occur in the human lung after starvation and account for this complication in anorexia nervosa.
Albustix Test for Urine Protein
Authors: D. M. Freeman
Journal: BMJ (1966)

NDIMWI!L JowuMU adherent to the oesophagus.When the neuroma was dissected away the oesophagus filled out but none the less dilators were passed.The " neuroma " had a cotton ligature in- corporated in it.Since then I have ligated only the distal vagal end, sometimes burying it under a serosal suture to obviate (?) such stump neuromata.The patient has had no recurrence of symptoms since.This case tends to support the view that stump neuromata may by them- selves cause symptoms as suggested in your leader.-Iam, etc.,
Commentary on the IK1 blockade controversy
Authors: A. G Kleber
Journal: Cardiovascular Research (1994)

Journal Article Commentary on the IK1 blockade controversy Get access Andre G Kléber Andre G Kléber Department of Physiology, University of Berne, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 5, May 1994, Page 720, https://doi.org/10.1093/cvr/28.5.720 Published: 01 May 1994
Prognostic Value of Perinodal Lymphovascular Invasion Following Radical Cystectomy for Lymph Node–positive Urothelial Carcinoma
Authors: Hans-Martin Fritsche, Matthias May, Stefan Denzinger, Wolfgang Otto, Sabine Siegert, Christian Giedl, Johannes Giedl, Fabian Eder, Abbas Agaimy, Vladimir Novotny, Manfred Wirth, Christian Stief, Sabine Brookman-May, Ferdinand Hofstädter, Michael Gierth, Atiqullah Aziz, Arkadius Kocot, Hubertus Riedmiller, Patrick J. Bastian, Marieta Toma, Wolf F. Wieland, Arndt Hartmann, Maximilian Burger
Journal: European Urology (2012)
CHARCOAL HÆMOPERFUSION IN THE TREATMENT OF FULMINANT HEPATIC FAILURE
Authors: B.G Gazzard, M.J Weston, I.M Murray-Lyon, H Flax, C.O Record, B Portmann, P.G Langley, E.H Dunlop, P.J Mellon, M.B Ward, Roger Williams
Journal: The Lancet (1974)