tbuckley/cabot-search huggingface dataset:
A piece of my mind. Prairie wedding
Authors: R. V. Ohmart
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Total hip arthroplasty versus resurfacing arthroplasty in the treatment of patients with arthritis of the hip joint: single centre, parallel group, assessor blinded, randomised controlled trial
Authors: M. L. Costa, J. Achten, N. R. Parsons, R. P. Edlin, P. Foguet, U. Prakash, D. R. Griffin
Journal: BMJ (2012)

To compare the clinical and cost effectiveness of total hip arthroplasty with resurfacing arthroplasty in patients with severe arthritis of the hip.Single centre, two arm, parallel group, assessor blinded, randomised controlled trial with 1:1 treatment allocation.One large teaching hospital in the United Kingdom.126 patients older than 18 years with severe arthritis of the hip joint, suitable for resurfacing arthroplasty of the hip. Patients were excluded if they were considered to be unable to adhere to trial procedures or complete questionnaires.Total hip arthroplasty (replacement of entire femoral head and neck); hip resurfacing arthroplasty (replacement of the articular surface of femoral head only, femoral neck remains intact). Both procedures replaced the articular surface of the acetabulum.Hip function at 12 months after surgery, assessed using the Oxford hip score and Harris hip score. Secondary outcomes were quality of life, disability rating, physical activity level, complications, and cost effectiveness.60 patients were randomly assigned to hip resurfacing arthroplasty and 66 to total hip arthroplasty. Intention to treat analysis showed no evidence for a difference in hip function between treatment groups at 12 months (t test, P=0.242 and P=0.070 for Oxford hip score and Harris hip score, respectively); 95% of follow-up data was available for analysis. Mean Oxford hip score was 40.4 (95% confidence interval 37.9 to 42.9) in the resurfacing group and 38.2 (35.3 to 41.0) in the total arthroplasty group (estimated treatment effect size 2.23 (-1.52 to 5.98)). Mean Harris hip score was 88.4 (84.4 to 92.4) in the resurfacing group and 82.3 (77.2 to 87.5) in the total arthroplasty group (6.04 (-0.51 to 12.58)). Although we saw no evidence of a difference, we cannot definitively exclude clinically meaningful differences in hip function in the short term. Overall complication rates did not differ between treatment groups (P=0.291). However, we saw more wound complications in the total arthroplasty group (P=0.056) and more thromboembolic events in the resurfacing group (P=0.049).No evidence of a difference in hip function was seen in patients with severe arthritis of the hip, one year after receiving a total hip arthroplasty versus resurfacing arthroplasty. The long term effects of these interventions remain uncertain.Current Controlled Trials ISRCTN33354155, UKCRN 4093.
1016 DIAGNOSIS OF HEPATOCELLULAR CARCINOMA (HCC) ≤2 CM: PROSPECTIVE VALIDATION OF GLYPICAN 3, HEAT-SHOCK PROTEIN 70 AND GLUTAMINE SYNTHETASE S TAINING IN BIOPSY SAMPLES
Authors: S. Tremosini, A. Forner, L. Boix, J. Rimóla, C. Rodriguez de Lope, M. Reig, L. Bianchi, J.M. Llovet, R. Vilana, C. Ayuso, M. Solé, J. Bruix
Journal: Journal of Hepatology (2011)
Educational Programs in US Medical Schools, 2000-2001
Authors: Barbara Barzansky
Journal: JAMA (2001)

We used data from the 2000-2001 Liaison Committee on Medical Education Annual Medical School Questionnaire, which had a 100% response rate, and other sources to describe the status of medical education programs in the United States. In 2000-2001, the number of full-time medical school faculty members was 103, 553, a 1.1% increase from 1999-2000. The 37, 092 applicants for the class entering in 2000 represented a 3.7% decrease from the number of applicants in 1999. The majority of medical schools (58%) were in the process of major curriculum review and change during 2000-2001. In 72 schools (58%), students were required to pass both Steps 1 and 2 of the United States Medical Licensing Examinations to advance or graduate. The availability of patients to participate in clinical teaching during 2000-2001 decreased in almost half of schools compared with 1999-2000. Many schools reported difficulty in recruiting or retaining volunteer faculty members to provide clinical education in the community. Forty medical schools provided monetary payment to some or all community volunteer faculty members.
Plasma Natriuretic Peptides for Community Screening for Left Ventricular Hypertrophy and Systolic Dysfunction
Authors: Ramachandran S. Vasan, Emelia J. Benjamin, Martin G. Larson, Eric P. Leip, Thomas J. Wang, Peter W. F. Wilson, Daniel Levy
Journal: JAMA (2002)

Several reports have suggested the usefulness of plasma brain natriuretic peptide (BNP) as a screening test for left ventricular hypertrophy (LVH) and systolic dysfunction (LVSD). Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women.To examine the usefulness of natriuretic peptides for screening for elevated LV mass and LVSD in the community.Community-based prospective cohort study of 3177 participants (1707 women) from the Framingham Study who attended a routine examination in 1995-1998.Receiver operating characteristic (ROC) curves, test sensitivity, specificity, positive and negative predictive values, and likelihood ratios for identifying elevated LV mass (sex-specific 90th percentile or higher of LV mass/[height](2)), LVSD (ejection fraction < or = 50% and/or fractional shortening <29%), and moderate to severe LVSD (ejection fraction < or = 40% and/or fractional shortening <22%) at different discrimination limits of plasma BNP and N-terminal proatrial natriuretic peptide (NT-ANP), with echocardiography as the criterion standard.The areas under the ROC curves for elevated LV mass or LVSD were at or below 0.75 for both peptides, were higher for men compared with women, and were similar for BNP and NT-ANP. The diagnostic performance of natriuretic peptides for LVSD improved in women but not in men when select high-risk subgroups were targeted. Discrimination limits based on high specificity (0.95) yielded better positive predictive values and likelihood ratios compared with age- and sex-specific reference limits yet only identified less than one third of participants who had elevated LV mass or LVSD.In our large community-based sample, the performance of BNP and NT-ANP for detection of elevated LV mass and LVSD was suboptimal, suggesting limited usefulness of natriuretic peptides as mass screening tools.
Observations on Hypoglycemia Associated with Mesodermal Tumors.
Authors: D. M. Hayes
Journal: Annals of Internal Medicine (1961)

s1 May 1961Observations on Hypoglycemia Associated with Mesodermal Tumors.D. M. Hayes, M.D., C. L. Spurr, M.D., F.A.C.P., J. H. Felts, M.D., (Assoc.), E. C. Miller Jr., M.D., (Assoc.)D. M. Hayes, M.D.Search for more papers by this author, C. L. Spurr, M.D., F.A.C.P.Search for more papers by this author, J. H. Felts, M.D., (Assoc.)Search for more papers by this author, E. C. Miller Jr., M.D., (Assoc.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1044_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe patient presented in this discussion represents the twenty-fourth reported case of the syndrome of spontaneous hypoglycemia associated with tumors of mesodermal origin. In an attempt to clarify the mechanism of hypoglycemia, the rate of utilization of exogenous glucose was determined and efforts were made to modify this rate by the administration of several drugs and hormones. Parallel studies also were done of blood levels of lactic acid, inorganic phosphorus, free fatty acids, and insulin-like activity.The rate of glucose utilization was found to be normal in this patient (3.38%/min.). This was increased by the addition of insulin (5.53%/min.). The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Winston-Salem, N. C. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1044-1044KeywordsBloodDrug administrationDrugsFatty acidsGlucoseHormonesHypoglycemiaInsulinLactic acidPhosphorus ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
1.62 Stimulated by IL-15 regulatory T cells CD4<sup>+</sup>CD25<sup>++</sup>(Tregs) isolated form bone marrow of rheumatoid arthritis (RA) patients suppress proliferation but not TNF production by responder CD4<sup>+</sup>CD25<sup>-</sup>T cells
Authors: M Massalska, A Radzikowska, E Kuca-Warnawin, M Plebanczyk, U Skalska, T Burakowski, I Janicka, A Kornatka, P Maldyk, E Kontny, W Maslinski
Journal: Annals of the Rheumatic Diseases (2014)

Background Previous studies from our laboratory have supported the concept that BM can actively participate in the pathogenesis of RA by TLR triggered B cell activation and distinct subpopulations of mature lymphocytes present in BM of osteoarthritis (OA) and RA patients. In the present study we analysed presence and functional activity of CD4+CD25++ Tregs isolated from RA and OA bone marrow samples. Materials and Methods Bone marrow mononuclear cells (BMMC) were obtained from BM of RA and OA patients undergoing hip bone replacement surgery. The Tregs phenotype and number was assessed by FACS analysis immediately after isolation. After in vitro 72h culture of BMMC with or without IL-15, CD4+CD25+++ Tregs were isolated by cell sorter for functional activity measured in proliferation assays and TNF and IL-17 production. Results As reported previously, CD4+Foxp3+ regulatory T cells are present in OA BM at higher number than in RA patients (4.7% vs 2.6% of CD4+, p = 0.0075). Tregs from both OA and RA BM suppress CD4+CD25- T cells proliferation (respectively 52.4%; p = 0.0001 in OA and 52.3%; p = 0.0001 in RA). After stimulation of BMMC by IL-15, suppression was similar (48.5%; p = 0.00006 in OA and 47.3%; p = 0.002 in RA). Tregs from OA patients suppress TNF production by CD25- cells independently on IL-15 stimulation (respectively 26.3%; p = 0.0001 in control and 30.2%; p = 0.0001 after IL-15 stimulation). In contrast to OA, Tregs isolated from RA patients suppress TNF production only in control (30.7%; p = 0.00005) but not after IL-15 stimulation (79.8%; ns). IL-15 does not trigger increase of CD4+Foxp3+IL-17+ cell number (respectively 0.5% vs 0.5% in OA and 0.3% vs 0.1% in RA), although stimulates IL-17 production by these cells (8904.8 vs 3525.5; p = 0.008 in OA and 7522.0 vs 3901.8; ns in RA). Conclusions Partial dependence of (overproduced in RA BM) IL-15 triggered Foxp3 expression, suggests that immunosuppression is an active process that takes part in bone marrow. However, lower number and limited functionality of Tregs present in RA bone marrow in comparison to OA may account for less efficient inhibition of T-cell activation in RA.
Private finance to build NHS hospitals
Authors: J. Warden
Journal: BMJ (1996)

Britain's first major NHS hospital to be built from scratch as a private finance venture—a pounds sterling170m ($255m) project at Norwich—was sanctioned last week by health secretary Stephen Dorrell. A pounds sterling90m ($135m) rebuilding scheme at Swindon was announced at the same time. They were among projects worth pounds sterling4.8bn ($7.2bn) in a Treasury package relaunching the government's private finance initiative, under which the private sector contracts to design, build, and manage public projects.

The new, 701 bed hospital at Norwich, to be built on a 63 acre greenfield site close to the University of East Anglia, will be built by the consortium Octagon …
Gastroparesis Associated With Muscular Dystrophy
Authors: SUNIL K. ROHIRA, JAY A. BIANCO
Journal: Clinical Nuclear Medicine (1993)

A 36-year-old woman with a known history of muscular dystrophy for several years and ventilator dependence suffered 5 days of nausea and vomiting. No evidence of gastric or duodenal ulcer, gastric cancer, vagotomy, diabetes, hypothyroidism, bulbar poliomyelitis, electrolyte abnormalities, anticholinergic medications or morphinelike drugs was present. The gastric emptying study performed on this patient revealed a t1/2 of more than 4 hours. A diagnosis of gastroparesis associated with muscular dystrophy was made by exclusion.
5-α Reductase Inhibitors and Risk of Hip Fracture
Authors: Madhavi Bollu
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENDER AND MORTALITY TREND IN 16,736 ACUTE CORONARY SYNDROMES’ PATIENTS: A 20-YEAR REGISTRY
Authors: Ayman A. El-Menyar, Emad Ahmed, Hajar AlBinAli, Hassan Al-Thani, Rajvir Singh, Abdulrazzak Gehani, Jassim Al Suwaidi
Journal: Journal of the American College of Cardiology (2013)
Expert Panel: The use of the pulmonary artery catheter
Authors: D. Bennett, J. Boldt, L. Brochard, P. Coriat, J. -F. Dhainaut, D. Edwards, F. Feihl, J. Groeneveld, M. Lamy, D. Lundberg, F. Lemaire, D. Payen, C. Perret, S. Reiz, J. -J. Rouby, D. Scheidegger, M. Singer, P. Suter, L. Thijs, J. -L. Vincent
Journal: Intensive Care Medicine (1991)
NOTES of a CASE of PERFORATING GASTRIC ULCER: OPERATION and RECOVERY
Authors: R. Shaw
Journal: BMJ (1898)

THE VISION OF RAILWAY OFFICI LS.[TH Bitmen 8 15 urethral catheter.The kidney was incised along the convex border and thoroughly explored for stone.None was present, but the calyces were found slightly sacculated.The con- stricted orifice of the ureter was longitudinally divided upon the catheter, which was passed from a small opening in the infundibulum through the stricture to the bladder, and the ends of the incisionl were drawn together, by the Heineke- Mikulicz method, hy means of two fiae silk sutures, passed after the manner of Lembert (see Figs. 4 and 5).The wound '.f
Seven international companies join global fund
Authors: F. Fleck
Journal: BMJ (2003)

Seven major international companies have joined forces with the Global Fund to Fight AIDS, Tuberculosis and Malaria to boost prevention and treatment of HIV infection and AIDS among their workers and their families in Asia and Africa.

The initiative, dubbed the global business coalition, comes after years of companies seeing their workforces decimated by the killer disease, and it won praise from US health secretary Tommy Thompson, who was in Nairobi for its official launch last Wednesday.

The companies involved are South Africa's electrical utility Eskom, …
QUANTITATIVE STUDY OF ANAPHYLACTIC CAPILLARY PERMEABILITY
Authors: W. H. MANWARING
Journal: JAMA (1924)

If the partially inflated lungs of dogs sensitized to horse serum are perfused with Locke's solution containing from 0.25 to 2 per cent, of horse serum, the following anapylactic phenomena are noted:<sup>1</sup>(<i>a</i>) A 75 per cent. reduction in the rate of perfusion flow. (<i>b</i>) Complete immobilization of the lungs, the lungs showing no tendency to collapse when the tracheal clamp is released. (<i>c</i>) Marked perivascular edema. (<i>d</i>) The escape of large amounts of perfusion fluid from the trachea. The tracheal flow usually begins during the fourth minute, and reaches a maximum by the seventh minute. With medium sized dogs, about 1,000 c.c. of perfusion fluid escapes from the trachea by the end of the seventh minute. To determine the nature of the anaphylactically increased capillary permeability thus demonstrated, various substances have been added to the perfusion fluid, and quantitative determinations of these substances made in the fluid recovered
Sustained increase in α5GABAA receptor function impairs memory after anesthesia
Authors: Agnieszka A. Zurek, Jieying Yu, Dian-Shi Wang, Sean C. Haffey, Erica M. Bridgwater, Antonello Penna, Irene Lecker, Gang Lei, Tom Chang, Eric W.R. Salter, Beverley A. Orser
Journal: Journal of Clinical Investigation (2014)

Many patients who undergo general anesthesia and surgery experience cognitive dysfunction, particularly memory deficits that can persist for days to months. The mechanisms underlying this postoperative cognitive dysfunction in the adult brain remain poorly understood. Depression of brain function during anesthesia is attributed primarily to increased activity of γ-aminobutyric acid type A receptors (GABA(A)Rs), and it is assumed that once the anesthetic drug is eliminated, the activity of GABA(A)Rs rapidly returns to baseline and these receptors no longer impair memory. Here, using a murine model, we found that a single in vivo treatment with the injectable anesthetic etomidate increased a tonic inhibitory current generated by α5 subunit-containing GABA(A)Rs (α5GABA(A)Rs) and cell-surface expression of α5GABA(A)Rs for at least 1 week. The sustained increase in α5GABA(A)R activity impaired memory performance and synaptic plasticity in the hippocampus. Inhibition of α5GABA(A)Rs completely reversed the memory deficits after anesthesia. Similarly, the inhaled anesthetic isoflurane triggered a persistent increase in tonic current and cell-surface expression of α5GABA(A)Rs. Thus, α5GABA(A)R function does not return to baseline after the anesthetic is eliminated, suggesting a mechanism to account for persistent memory deficits after general anesthesia.
Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection
Authors: Xiu-Da Shen, Bibo Ke, Yuan Zhai, Feng Gao, Dean Anselmo, Charles R. Lassman, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski
Journal: Hepatology (2003)

Ischemia/reperfusion (I/R) injury remains an important problem in clinical organ transplantation. There is growing evidence that T lymphocytes, and activated CD4+ T cells in particular, play a key role in hepatic I/R injury. This study analyzes the role of signal transducer and activator of transcription 4 (Stat4) and Stat6 signaling in liver I/R injury. Using a partial lobar warm ischemia model, groups of wild-type (WT), T cell-deficient, Stat4-/Stat6-deficient knockout (KO) mice were assessed for the extent/severity of I/R injury. Ninety minutes of warm ischemia followed by 6 hours of reperfusion induced a fulminant liver failure in WT and Stat6 KO mice, as assessed by hepatocellular damage (serum alanine aminotransferase [sALT] levels), neutrophil accumulation (myeloperoxidase [MPO] activity) and histology (Suzuki scores). In contrast, T cell deficiency ( nu/nu mice) or disruption of Stat4 signaling (Stat4 KO mice) reduced I/R insult. Unlike adoptive transfer of WT or Stat6-deficient T cells, infusion of Stat4-deficient T cells failed to restore hepatic I/R injury and prevented tumor necrosis factor α (TNF-α) production in nu/nu mice. Diminished TNF-α/Th1-type cytokine messenger RNA (mRNA)/protein elaborations patterns, along with overexpression of heme oxygenase-1 (HO-1)-accompanied hepatic cytoprotection in Stat4 KO recipients. In contrast, HO-1 depression restored hepatic injury in otherwise I/R resistant Stat4 KOs. In conclusion, Stat4 signaling is required for, whereas Stat4 disruption protects against, warm hepatic I/R injury in mice. The cytoprotection rendered by Stat4 disruption remains HO-1-dependent.
MISTAKES IN THE DIAGNOSIS OF PULMONARY TUBERCULOSIS.
Authors: HARRY LEE BARNES
Journal: JAMA (1907)

The possibility of limiting tuberculosis rests on our ability either to cure those infected or to prevent the infection of others. What we accomplish in both these fields depends very largely on an early diagnosis of the disease. That persons having pulmonary tuberculosis frequently fail to consult a physician in an early stage of the disease and that physicians frequently fail to diagnose early cases that are presented are well-known facts. How often and for how long a period patients are negligent of their symptoms and how often and for what reasons physicians actually fail to diagnose their cases are not so well understood. Among English writers who have recently called attention to the mistakes tabulated in this article are: Bronchitis: Trudeau,<sup>1</sup>Butler,<sup>2</sup>Miner,<sup>3</sup>Landis,<sup>4</sup>Norris,<sup>5</sup>Mohr,<sup>6</sup>Pryor.<sup>7</sup> Grippe: Bonney,<sup>8</sup>Trudeau,<sup>1</sup>Koch,<sup>9</sup>Hatfield,<sup>10</sup>Norris,<sup>5</sup>Pryor,<sup>7</sup> Hemoptysis: Wells<sup>11</sup>
Roth: diabetes and receptors
Authors: William Check
Journal: JAMA (1979)

the traditional treatments of diabetes, laboratory studies were uncovering the reason. A radioimmunoassay for insulin—the first such assay ever developed—was used by Solomon A. Berson, MD, and Rosalyn S. Yalow, PhD, in the early 1960s to measure circulating levels of insulin in diabetics. Their data showed that "only 20% to 30% of diabetics are insulin-deficient," Roth recalls, "and that in the majority of cases, diabetes is not an insulin-deficiency disease." These findings came at the time that Roth was finishing his internship and residency at Washington University. Subsequently, he was awarded a fellowship by the American Diabetes Association to study in Berson and Yalow's laboratory, where he worked on a radioimmunoassay for growth hormone. (Roth has decided views on the role of a physician going into basic research. "You start out with a severe disadvantage in formal scientific training. But you have the advantage that