tbuckley/cabot-search huggingface dataset:
Is Running Associated With Degenerative Joint Disease?
Authors: Richard S. Panush
Journal: JAMA (1986)

Little information is available regarding the long-term effects, if any, of running on the musculoskeletal system. We therefore compared the prevalence of degenerative joint disease among 17 male runners (mean age, 56 years; height, 180 cm [5 ft 11 in]; and weight, 73.02 kg [161 lb]) with 18 male nonrunners (mean age, 60 years; height, 178 cm [5 ft 10 in]; and weight, 78 kg [171 lb]). Running subjects (53% marathoners) ran a mean of 44.8 km (28 miles)/wk for 12 years. Pain and swelling of hips, knees, ankles, and feet and other musculoskeletal complaints among runners were comparable with those among nonrunners. Radiologic examinations (for osteophytes, cartilage thickness, and grade of degeneration) also were without notable differences among groups. We did not find an increased prevalence of osteoarthritis among the runners. Our observations suggest, within the limits of our study, that long-duration, high-mileage running need not be associated with premature degenerative joint disease in the lower extremities. (<i>JAMA</i>1986;255:1152-1154)
Dichotomies in discovery
Authors: S. Vaisrub
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Right Upper Canine Tooth Removed from the Left Orbit of a Child
Authors: J. W. Cousins
Journal: BMJ (1887)

THB BBRIfJAT fEDICAi JTOUI.j4l-The short tube, about six-inches in length, is passed th-rough -the stricture till the funnel rests upon its upper face.It is passed on the end of a conical bougie, or by a special introducer of copper wire, which anyone can make.The advantage of the wire is, that the tube can be directed down the posterior wall of the gullet, the trachea beinDg avoided; but it should always be made quite supple first, and tried on a bougie, as a tortuous passage may thus be easily and.safely tra- versed.The silk is looped over the ear, and held by a piece of strap- ping.The patient swallows down to the funnel, through which the fluids pass to the stomach.The best form of tube is that made on a silk web, and it is essential that the thickness of the wall does not increase in proportion with the increase in size of the lumen, but re- mains nearly the same for all sizes.This gives a wider channel, and secures softness and pliability, the funnel moulding itself to the shape of the cesophagus, and it is quite stout enough to produce and maintain dilatation of the stricture.These tubes, with the proper silk attached, are well made by Messrs. Down Bros., of St. Thomas's Street, S. E.The Effect of the Tube.-AsKrishaber pointed out, dilatation of a
RU-486: Hoechst-Roussel (US), Hoechst AG, Roussel Uclaf SA, and Hoechst-Roussel Pharmaceuticals Inc
Authors: Victor J. Bauer
Journal: JAMA (1991)

<h3>To the Editor. —</h3> I am writing to clarify an inaccurate and misleading statement that appears in the Regelson et al Commentary, "Beyond 'Abortion': RU-486 and the Needs of the Crisis Constituency."<sup>1</sup>In this Commentary, Dr Regelson and colleagues incorrectly associate Hoechst-Roussel Pharmaceuticals Inc with the compound RU-486 (mifepristone). RU-486 was developed in France by the company Roussel Uclaf SA, a minority shareholder of Hoechst-Roussel. Hoechst-Roussel has absolutely no connection with this compound—it did not develop the compound, nor does it manufacture or market RU-486.
Evidence for the absorption of bile acids in the proximal small intestine of normo- and hyperlipidaemic subjects.
Authors: B Angelin, K Einarsson, K Hellstrom
Journal: Gut (1976)

Bile acid composition was determined in duodenal and jejunal aspirates obtained under fasting conditions in normolipidaemic controls and in patients with the type IIa and type IV lipoprotein patterns. In 17 out of the 22 subjects studied, the duodenal as compared with the jejunal aspirates contained proportionally more CD (chenodeoxycholic acid) than C (cholic acid). The two types of aspirates also differed slightly with regard to the D (deoxycholic acid): CD ratio, which was higher in samples drawn from the jejunum. These findings, compatible with an absorpiton of about 30% of CD in the upper small intestine, were approximately the same in all groups of patients. As evidenced by additional experiments in two subjects, an oral intake of cream does not significantly influence the absorption of CD in the upper small intestine.
Pathological Changes in Human Aortic Valve Homografts
Authors: DENNIS D. REICHENBACH, HITOSHI MOHRI, K. ALVIN MERENDINO
Journal: Circulation (1969)

The pathological changes in 34 homograft valves transplanted to the subcoronary position are described. The valves had been in place up to 30 months and did not show evidence of graft rejection. There was evidence of repopulation of the graft by host cells and endothelialization of the leaflet in one case. There were ten instances of homograft valve failure with valve cusp rupture in eight. In four patients who died 7 to 17 months after implantation, unusual organisms were demonstrable in the thickened calcified valve, although no organisms could be isolated during life. An unidentified fungus was present in two cases and possible mycoplasma in two other cases. The demonstration of homograft infection with unusual organisms suggests that special attention needs to be placed on attempted isolation of organisms in patients with homografts. The relationship of the method of sterilization and storage of homografts used in this series to these infections is unclear.
Excess Prevalence of Pneumocystis carinii Pneumonia in Patients Treated for Lymphoma with Combination Chemotherapy
Authors: MARCIA J. BROWNE
Journal: Annals of Internal Medicine (1986)

A significantly greater prevalence of interstitial pulmonary infiltrates and Pneumocystis carinii pneumonitis occurred on one arm of a randomized study comparing ProMACE-CytaBOM (prednisone, methotrexate with leucovorin, doxorubicin, cyclophosphamide, etoposide; cytarabine, bleomycin, vincristine, methotrexate with leucovorin) to ProMACE-MOPP (ProMACE, mechlorethamine, vincristine, prednisone, procarbazine) chemotherapy in patients with lymphoma. Of the 37 patients receiving ProMACE-CytaBOM, 13 (35.1%) developed an interstitial pulmonary infiltrate compared with 3 of 32 (9.4%) patients receiving ProMACE-MOPP (p2 = 0.02). Of the 13 patients receiving ProMACE-CytaBOM who had infiltrates, open lung biopsy in 7 showed P. carinii; 5 others had clinically suspected P. carinii pneumonia, and 1 had blastomycosis. No patient receiving ProMACE-MOPP had documented or suspected P. carinii pneumonia. Of patients with infiltrates, 3 of 13 on ProMACE-CytaBOM but 0 of 3 on ProMACE-MOPP died. Two other patients on ProMACE-CytaBOM who had P. carinii pneumonia died. Groups did not differ in predisposing risk factors or patient history. The exact cause for the increased prevalence of P. carinii infection in patients receiving ProMACE-CytaBOM was not ascertained. These data emphasize that new drug regimens may lead to unanticipated complications.
Elements of Resistance to a Combined Medical and Psychotherapeutic Program in Anorexia nervosa
Authors: R.A. Pierloot, W. Wellens, M.E. Houben
Journal: Psychotherapy and Psychosomatics (1975)

According to several follow-up studies in the literature, anorexia nervosa has to be considered as an affection with a grave prognosis. We have studied the outcome in a group of 32 female patients who could be considered as homogeneous in a number of aspects. The following five criteria, on which the delineation of the syndrome is based, were realized in all the patients: considerable weight loss; limited food intake; amenorrhea; juvenile age of onset; absence of primary organic or specific psychotic disorder. All of them presented a serious symptomatology and had undergone some previous treatment under the form of ambulatory psychotherapy and/or forced feeding. They all received, during their admission in the same hospital, the same form of combined intensive medical and psychotherapeutic treatment. All of them maintained regular psychotherapeutic contacts with the same psychiatrist. According to the outcome, the patients could be categorized into three groups: the cured, the improved, the unimproved. In order to circumscribe some prognostic elements, we have compared a number of clinical, family and personality variables in these groups. As favorable clinical factors can be mentioned: younger age at admission and shorter duration of the illness. Manifestations of impulsive behavior (automutilation, kleptomania, fugues, etc. ...) and sucide attempts are unfavorable. No definite family factors can be defined, although the absence of psychological interaction with the father seems to be unfavorable. A better prognostic outcome is offered by the following personality characteristics, determined by psychological testing: lower neuroticism and higher self-defensiveness on the ABV; a lower general profile and especially a lower score on the schizophrenia scale of the MMPI; less pronounced tendencies to infantile regression, passivity and sexual repression as these are expressed in the TAT.
Increased Prevalence of Dysplastic and Malignant Lip Lesions in Renal-Transplant Recipients
Authors: Gaston N. King, Claire M. Healy, Mary T. Glover, Jonathan T.C. Kwan, David M. Williams, Irene M. Leigh, Helen V. Worthington, Martin H. Thornhill
Journal: New England Journal of Medicine (1995)

Renal-transplant recipients are known to have increased rates of skin cancer associated with exposure to the sun. Little is known, however, about the prevalence and histologic features of lesions of the lips in these patients, or about risk factors for such lesions.We examined the lips of 160 renal-transplant recipients (105 men and 55 women; mean [+/- SD] age, 48 +/- 13 years) and 160 normal subjects matched with the transplant recipients for age, sex, and skin type. The mean length of time between transplantation and the examination was 69 +/- 52 months; 58 percent of the recipients had received their grafts more than 60 months earlier.Among the 160 renal-transplant recipients, 21 (13 percent) had leukoplakia; in 2 (1.2 percent) the leukoplakia contained squamous-cell carcinoma. In contrast, only one normal subject (0.6 percent) had leukoplakia. Histologically, 13 of the 21 leukoplakias (62 percent) in the renal-transplant recipients who underwent biopsy were dysplastic, and 2 (10 percent) contained squamous-cell carcinoma. Actinic change was evident in 91 percent of the dysplastic lesions but not in the nondysplastic lesions (P < 0.001). Exposure to the sun and smoking were risk factors for dysplastic and malignant lip lesions in the renal-transplant recipients (P < 0.001 and P = 0.003, respectively). Among these recipients, only men had dysplastic or malignant lip lesions (P = 0.006); lipstick was used frequently by 73 percent of the women. The clinical appearance of lip lesions did not predict the presence of dysplasia or cancer.Renal-transplant recipients have an increased prevalence of leukoplakia, dysplasia, and cancer of the lip.
Allergic contact dermatitis to oestradiol patches might have been expected
Authors: K. Batta, I. S Foulds
Journal: BMJ (1998)

We conclude, firstly, that the management of women who present to accident and emergency departments requiring emergency contraception is in disarray and that experts should suggest a common approach.This would ensure consistent management throughout the United Kingdom based on published data reflecting the safety of such drug treatment.Secondly, any protocol should be realistic and should spare women the inconvenience and often the embarrassment of seeking such emergency care; it should also include recommendations concerning follow up.
Fertility patterns after appendicectomy: historical cohort study
Authors: R. Andersson, M. Lambe, R. Bergstrom
Journal: BMJ (1999)

<h3>Abstract</h3> <b>Objective</b>: To examine fertility patterns in women who had their appendix removed in childhood. <b>Design</b>: Historical cohort study with computerised data and fertility data for this cohort and for an age matched cohort of women from the Swedish general population. The cohorts were followed to 1994. <b>Setting</b>: General population. <b>Participants</b>: 9840 women who were under 15 years when they underwent appendicectomy between 1964 and 1983; 47 590 control women. <b>Main outcome measures</b>: Diagnoses at discharge. Distributions of age at birth of first child among women with perforated and non-perforated appendix and women who underwent appendicectomy but were found to have a normal appendix compared with control women by using survival analysis methods. Parity distributions at the latest update of the registry were also examined. <b>Results</b>: Women with a history of perforated appendix had a similar rate of first birth as the control women (adjusted hazard ratio 0.95; 95%confidence interval 0.88 to 1.04) and had a similar distribution of parity at the end of follow up. Women who had had a normal appendix removed had an increased rate of first births (1.48;1.42 to 1.54) and on average had their first child at an earlier age and reached a higher parity than control women. <b>Conclusion</b>: A history of perforated appendix in childhood does not seem to have long term negative consequences on female fertility. This may have important implications for the management of young women with suspected appendicitis as the liberal attitude to surgical explorations with a subsequently high rate of removal of a normal appendix is often justified by a perceived increased risk of infertility after perforation. Women whose appendix was found to be normal at appendicectomy in childhood seem to belong to a subgroup with a higher fertility than the general population.
321 A NOVEL SMALL-MOLECULE AURORA KINASE INHIBITOR WITH STRONG ANTIPROLIFERATIVE ACTIVITY IN HUMAN HCC CELL LINES
Authors: D. Benten, G. Keller, A. Gontarewicz, A. Quaas, S. Balabanov, H. Wege, J. Schrader, A.W. Lohse, J. Moll, T. Brummendorf
Journal: Journal of Hepatology (2008)
Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein.
Authors: J P Clayton, G M Gammon, D G Ando, D H Kono, L Hood, E E Sercarz
Journal: The Journal of Experimental Medicine (1989)

Experimental allergic encephalomyelitis (EAE) is a model of antigen-specific T cell-mediated autoimmune disease. The alpha-acetylated, NH2-terminal nine amino acids (1-9NAc) of myelin basic protein (MBP) represents the dominant T cell epitope for the induction of EAE in the B10.PL (H-2u) strain. We tolerized neonatal B10.PL mice to 1-9NAc and studied the proliferative responses to this peptide and to whole MBP. Mice exposed to 1-9NAc in the neonatal period were tolerant to subsequent challenge at the proliferative T cell level. Similarly, in the 1-9NAc-tolerant group, both the incidence and severity of 1-9NAc induced EAE were greatly reduced. The fact that we were able to tolerize mice normally responsive to MBP suggests that this self antigen is sequestered (within the central nervous system) and hence tolerance to it is not normally induced. No significant difference in disease incidence was seen in response to rat MBP between control animals and 1-9NAc-tolerized mice (50% in both groups), demonstrating the presence of at least one additional encephalitogenic determinant elsewhere on the molecule. We have successfully prevented disease induction by peptide-induced tolerization. Tolerance induction by peptides provides a new and specific strategy in the prevention of autoimmunity. However, it will be clearly necessary to fully define all epitopes potentially capable of inducing pathogenic T cells to ensure complete and effective therapy of T cell-mediated autoimmune disease.
Accessory Valvular Tissue Causing Subpulmonary Stenosis in Corrected Transposition of Great Vessels
Authors: MORRIS J. LEVY, C. WALTON LILLEHEI, LARRY P. ELLIOTT, LEWIS S. CAREY, PAUL ADAMS, JESSE E. EDWARDS
Journal: Circulation (1963)

This study reveals three cases of corrected transposition (one with total situs inversus) where an accessory flap or umbrella-like formation of the venous atrioventricular valve presented into the outflow tract of the venous ventricle causing severe subpulmonary stenosis. In one case the ventricular septum was intact, while in each of the other two, a ventricular septal defect lay below the obstruction. The latter combination effected a right-to-left shunt at ventricular level. These cases are important because they portray anatomic details of a condition which, although uncommon, is potentially curable. Clinical identification of the subpulmonary stenosis appears best to be accomplished by selective angiocardiography at the level of the venous ventricle.
US Foreign Medical Graduates
Authors: David Francis Bovill
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I am an Americanborn, senior medical student from La Universidad Autonoma de Guadalajara. This letter addresses current policies concerning US foreign medical graduates (USFMGs). It appears to me that basic rights are being violated. At present, many hospitals are staffed by foreign-born foreign medical graduates (FBFMGs). Every year more FBFMGs enter the US medical establishment. No special allowances are made for US citizens enrolled in foreign medical schools. These persons are discriminated against in terms of examinations, clerkships, and final licensure. Let me cite a few examples of present trends. In 1978 the Kennedy Bill was designed to aid USFMGs. This bill required US medical schools to accept a certain number of transfers from foreign schools each year. The bill was to run for three years but was cut to one. In 1979, with the approval of the Association of American Medical Colleges and the National Board
ANEURYSM OF CHOLECYSTIC ARTERY
Authors: John H. Schaefer
Journal: JAMA (1953)

<h3>To the Editor:—</h3> A recent article on the management of gastrointestinal hemorrhage of undetermined origin (Bockus, H. L., and others:<i>J. A. M. A.</i><b>152:</b>1228 [July 25] 1953) reminds me of what I believe to be a unique case. The patient died in 1939, and I performed the autopsy. A woman in her late forties was admitted to a general hospital. She had been under treatment for syphilis by her private physician for several months. About one month before admission to the hospital, she passed a large, but unknown, amount of bright red blood by rectum. Hospitalization was urged by her physician but refused. Hemorrhage occurred again two or three times. The woman became very weak and finally consented to go to the hospital. On admission she was very weak and pale and had an erythrocyte count of less than 2 million, with a correspondingly low hemoglobin level. The
The Variability of Genetic Disease
Authors: Han G. Brunner
Journal: New England Journal of Medicine (2012)

It is never boring to be a physician because patients are so different. Each patient has a story to tell, and few have disorders that match textbook descriptions. By the same token, we need to be careful when predicting the future for our patients, and finding the appropriate therapy is often a matter of trial and error as much as science and protocol. Why are diseases so variable? A study by Girirajan et al.1 in the Journal provides some new insights.There are three obvious candidates for determining disease manifestation, or phenotype, as geneticists call it. First, the environment has . . .
The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3
Authors: Zuojia Chen, Joseph Barbi, Shurui Bu, Huang-Yu Yang, Zhiyuan Li, Yayi Gao, Dilini Jinasena, Juan Fu, Fang Lin, Chen Chen, Jing Zhang, Ning Yu, Xiangpei Li, Zhao Shan, Jia Nie, Zhimei Gao, Hong Tian, Yangyang Li, Zhengju Yao, Ying Zheng, Benjamin V. Park, Ziyi Pan, Jing Zhang, Eric Dang, Zhiguang Li, Honglin Wang, Weibo Luo, Liwu Li, Gregg L. Semenza, Song-Guo Zheng, Karin Loser, Andy Tsun, Mark I. Greene, Drew M. Pardoll, Fan Pan, Bin Li
Journal: Immunity (2013)
The cutaneous reactions produced by dibenzoxazepine (CR)
Authors: P. HOLLAND
Journal: British Journal of Dermatology (1974)

Dibcnz (b.f)-i,4-oxazepme (CR), a substance known to be markedly irritant to skin, has been applied in graded quantities to the skin of volunteers as (a) dry tnaterial, and (b) when moistened with saline. The cutaneous reactions produced have been observed and these have been discussed in comparison with those produced by (u-chloroacetophenonc (CN) and o-chlorobenzylidenemalononitrile (CS). CR has been shown to be very potent in causing skin discomfort and pain, equivalent roughly to CN and more so than CS. The effects of CR tend to disappear rapidly following its removal but recur, at reduced intensity, when the affected area is washed, even up to 24 h later. The erythema produced by CR fades rapidly and does not recur, whereas that produced by CN and CS remains for a much longer period. Vesic-ation could not be produced with CR, even under adverse and unrealistic conditions. CR is capable of producing acute cutaneous discomfort, apparently out of proportion to the very temporary and moderate changes observed in the skin.
COMPARISON OF DUAL ENERGY X-RAY ABSORPTIONETRY, HEIGHT-CIRCUMFERENCE TABLES, AND HYDRODENSITOMETRY FOR PREDICTION OF PERCENT BODY FAT
Authors: S. Cavanah, U. Fohlmefster, A. Ramos-Gabatin, R. Wyatt
Journal: Clinical Nuclear Medicine (1992)

S: APRIL 9–12, 1992 San Antonio Convention Center & Hyatt Regency Hotel SAN ANTONIO, TEXAS Southwestern Chapter Society of Nuclear Medicine SPECT/PET Nuclear Cardiology Symposium and 37th Annual Meeting: PDF Only
ERRORS IN LABORATORY PROCEDURES
Authors: Richard J. Henry
Journal: JAMA (1953)

To the Editor:  —Surveys of laboratory accuracy (Shuey, H. E., and Cebel, J.: Bull. U. S. Army M. Dept.  9 :799, 1949) have given adequate proof that too many laboratory reports are in such gross error that they are not only misleading but, at times, a cause of serious errors. It is not our purpose to delve into the whys and wherefores of such conditions but, rather, to discuss the fact that, assuming every laboratory procedure were perfectly performed, there would still be error. If this error were small enough to be unimportant in every instance then it would be of academic interest. Unfortunately, however, in many instances this error is larger than might be desired, because, through no fault of the laboratory, it is beyond reasonable control. This being the case it behooves the physician to gain at least a superficial understanding of the problems involved.  In measuring a