tbuckley/cabot-search huggingface dataset:
Responsiveness of FDG PET/CT to Treatment of Patients With Active Chronic Sarcoidosis
Authors: Dragana P. Sobic-Saranovic, Isidora T. Grozdic, Jelica Videnovic-Ivanov, Violeta Vucinic-Mihailovic, Vera M. Artiko, Djordjije Z. Saranovic, Smiljana V. Pavlovic, Vladimir B. Obradovic
Journal: Clinical Nuclear Medicine (2013)

Purpose This study aimed to compare baseline to follow-up 18F-FDG PET/CT findings after treatment for active chronic sarcoidosis and to correlate changes on 18F-FDG PET/CT with changes in clinical status. Patients and Methods The sample included 66 patients with chronic sarcoidosis and evidence of active inflammation on baseline 18F-FDG PET/CT for which they received therapy. Of these 66 patients, 30 returned for the follow-up 18F-FDG PET/CT after 12 (5) months to evaluate response to treatment. They were also asked to indicate changes in clinical status. Baseline characteristics of patients who did and did not return for the follow-up were compared to assess selection bias. Results SUVmax was significantly decreased at the follow-up compared with baseline 18F-FDG PET/CT (8.46 [3.52] vs 4.90 [0.96]; P = 0.006), primarily in the mediastinum. Inflammatory activity appeared absent in 9 patients, decreased in 12 patients, and increased in 9 patients, with the corresponding changes in SUVmax of −80%, −41%, and +54%, respectively. The changes on 18F-FDG PET/CT were in agreement with self-perceived changes in clinical symptoms (P = 0.019). The angiotensin-converting enzyme at the follow-up was not significantly different from baseline (49.80 [19.25] vs 46.35 [25.58], P = 0.522). There was no difference in baseline characteristics of patients who did and did not return for the follow-up. Conclusions 18F-FDG PET/CT is able to detect clinically meaningful changes in magnitude and extent of inflammatory activity in patients receiving treatment for active chronic sarcoidosis. Thus, 18F-FDG PET/CT is a valuable adjunct to clinical evaluation for monitoring the response to treatment in these patients.
Adenocarcinoma of the esophagus in Switzerland
Authors: F. Levi
Journal: JAMA (1991)

To the Editor.—  Blot et al 1 provide comprehensive data on an increasing incidence of adenocarcinomas of the esophagus and gastric cardia, confirming previous clinical and epidemiologic observations.  The Cancer Registry of the Canton Vaud (covering approximately 530 000 inhabitants in the French-speaking part of Switzerland) has had a specific interest in esophageal adenocarcinomas derived from a privileged situation in terms of traditional attention and careful endoscopic and histopathologic examinations of esophageal lesions. 2 Average annual age-adjusted (on the world standard population) incidence rates for various histological types of esophageal cancers in two separate calendar periods (1976 through 1981 and 1982 through 1987) are given in the Table.  In men, there was a decline for squamous cell carcinomas (from 7.2 to 5.2 per 100 000) but a significant rise for adenocarcinomas (from 0.4 to 1.6 per 100 000; P
Fat Necrosis in the Abdomen After Surgery Close to the Pancreas: Potential False-Positive on Positron Emission Tomography
Authors: Madhusudhan P. Reddy, Guillermo Sangster, Maureen G. Heldmann, David L. Lilien
Journal: Clinical Nuclear Medicine (2006)

F-18 fluoro-2-deoxyglucose positron emission tomography (FDG PET) is widely used for staging and restaging patients with various malignancies. A number of interpretive pitfalls have been described, including inflammation, infection, and variations in physiological tracer uptake pattern. We describe a false-positive scan in a patient with adenocarcinoma of the duodenum, who underwent a pyloric sparing Whipple procedure. In interpreting a study in this setting, fat necrosis should appear in the differential diagnosis because surgery in and around the pancreas is thought to potentially cause lipase release, leading to fat necrosis.
Care of Biopsy Specimen
Authors: Francis A. Ellis
Journal: JAMA (1963)

To the Editor:  —In reference to the editorial, Care of the Biopsy Specimen ( JAMA  184: 654 [May 25] 1963), it is most important in dermatology that biopsies be selected from the proper site at the right time, etc. There are a few simple factors which, if followed, will increase biopsy value. Ordinarily, a biopsy should be at least 4 mm in diameter and 2 mm in depth. With the possible exception of lesions of the nose, biopsy of this size does not increase scarring.  A considerable number of skin biopsies are valueless because they are too small. This results in a waste of time and money and is a disservice to the patient.  The physician must not pinch the biopsy with forceps, etc, as this will make that part of the biopsy which has been pinched worthless. If one puts the biopsy in peroxide for 1 min, it will remove
Detection of Recurrent Skull Osteosarcoma by Skull Single Photon Emission Computed Tomography Using Tc-99m Methylene Diphosphonate
Authors: Katsumi Abe, Shigeru Kosuda, Shoichi Kusano, Katsumi Shima
Journal: Clinical Nuclear Medicine (2004)

A 24-year-old woman was admitted with recurrence of primary osteosarcoma of the skull. Skull single photon emission computed tomography (SPECT) using Tc-99m methylene diphosphonate (MDP) revealed increased tracer uptake in recurrent tumor in the parieto-occipital region as well as in the rim of the craniotomy.
Anorexia and weight loss
Authors: E Kalaitzakis, V A Fisichella, S Anderson
Journal: Gut (2008)

An 86-year-old man was referred for an upper gastrointestinal (GI) endoscopy with a 2 month history of anorexia and weight loss. He did not have any other symptoms and was afebrile. Medical history included type 2 diabetes mellitus …
Morphologic Study of Intermediate Filaments in Rat Hepatocytes
Authors: Samuel W. French, Isao Kondo, Tetsuya Irie, Thomas J. Ihrig, Nancy Benson, Robert Munn
Journal: Hepatology (1982)

Rat livers perfused with 0.5% Triton X-100 for 15 to 90 min followed by 1% sodium dodecyl sulfate for 30 min were studied by electron microscopy and polyaerylamide gel electrophoresis. After 15 min of perfusion, a rich network of intermediate filaments and microtubules was visualized in the cytoplasm of hepatocytes. Using stereopairs, branching was visualized. Connections of filaments were noted with nuclei, centrioles, microtubules, vesicles, and rough endoplasmic reticulum. The existence of connections supported the concept that intermediate filaments may function to integrate mechanically the cytoplasmic space as postulated by Lazarides.
AN UNUSUAL CASE OF FRACTURE OF THE SKULL.
Authors: F. H. PECK
Journal: JAMA (1896)

I have to beg the indulgence of the Academy for bringing up in a very new and crude way a history of a case which has always been extremely interesting to me, and I will explain how it is that I am unable to give more complete data of the case. It is a case of fracture of the skull which occurred during my service at the State Emigrant Hospital, New York, when that institution was located upon Ward's Island and under the government of the New York commissioners of immigration. Some three or four years following my service the department was taken out of the hands of the New York State commissioners of immigration and put into the hands of a single-headed commission which was under the general government, and the hospital was removed from Ward's Island to Ellis Island in the harbor so that my data in regard
Allergen-induced Proliferation and Interleukin-5 Production by Bronchoalveolar Lavage and Blood T Cells after Segmental Allergen Challenge
Authors: S. J. TILL, S. R. DURHAM, K. RAJAKULASINGAM, M. HUMBERT, D. HUSTON, R. DICKASON, A. B. KAY, C. J. CORRIGAN
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

In order to detect and characterize allergen-specific T cells in the airways of atopic asthmatics, we measured proliferation and cytokine production by bronchoalveolar lavage (BAL) T cells isolated from Dermatophagoides pteronyssinus (Der p)-sensitive asthmatics and nonatopic control subjects, and compared the results with those generated using peripheral blood (PB) T cells. BAL and PB mononuclear cells were collected 24 h after segmental allergen challenge by fibreoptic bronchoscopy and venepuncture, respectively. T cells purified from BAL and PB were stimulated with autologous, irradiated antigen-presenting cells and D. pteronyssinus extract or a control, nonallergen antigen (M. tuberculosis purified protein derivative [PPD]). IL-5 and IFN- γ concentrations were measured in culture supernatants by ELISA, and T-cell proliferation by 3H-thymidine uptake. D. pteronyssinus-induced proliferation of T cells derived from both BAL and PB was elevated in asthmatics when compared with control subjects (p < 0.05), whereas PPD-induced proliferation was equivalent in both compartments. In the asthmatics, D. pteronyssinus-induced proliferative responses of equivalent numbers of BAL and PB T cells obtained after allergen challenge were statistically equivalent. Nevertheless, BAL T cells stimulated with D. pteronyssinus produced significantly greater amounts of IL-5 than did PB T cells (p < 0.05). Allergen-induced proliferation and IL-5 production by BAL T cells in the asthmatics after segmental allergen challenge correlated with the percentages of eosinophils in the BAL fluid (p < 0.01). Further, BAL T cells from asthmatic patients produced significantly higher amounts of IL-5 than did the same number of cells from nonatopic control subjects (p < 0.05). We conclude that, in D. pteronyssinus-sensitive asthmatics, allergen-specific T cells can be detected in the bronchial lumen after allergen challenge and that allergen-induced proliferation and IL-5 production by these cells correlates with local eosinophil influx. Although bronchial luminal T cells show an equivalent proliferative response to allergen stimulation as compared with PB T cells, they do produce more IL-5, consistent with the hypothesis that local differentiation or priming of these cells within the bronchial mucosal environment results in upregulation of allergen-induced IL-5 secretion.
HOW DO NON-INVASIVE IMAGING FACILITIES PERCEIVE THE ACCREDITATION PROCESS? RESULTS OF AN INTERSOCIETAL ACCREDITATION COMMISSION (IAC) SURVEY
Authors: Warren Manning, Mary Farrell, Louis Bezold, John Choi, Kevin Cockroft, Heather Gornik, Scott Jerome, Sandra Katanick, Gary Heller
Journal: Journal of the American College of Cardiology (2014)
Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning
Authors: Takahiro Fukuda, Michael Boeckh, Rachel A. Carter, Brenda M. Sandmaier, Michael B. Maris, David G. Maloney, Paul J. Martin, Rainer F. Storb, Kieren A. Marr
Journal: Blood (2003)
Mycobacterium fortuitum—A Human Pathogen
Authors: W. LEE HAND
Journal: Annals of Internal Medicine (1970)

Mycobacterium fortuitum is often considered to be merely a saprophytic organism in spite of adequate evidence to the contrary. To illustrate the clinical manifestations and relative frequency of M. fortuitum infections, six recently observed cases are presented. These include five patients with cutaneous infection or abscess disease after trauma (one of whom also had suppurative adenitis) and one patient with a cauda equina abscess and meningitis. The most frequently reported M. fortuitum illnesses are cutaneous and deeper infections after trauma, pulmonary disease, and corneal infection. Infections associated with contaminated trauma, including corneal infection, are related to the widespread distribution of M. fortuitum in nature. Pulmonary infection is usually superimposed on preexisting lung disease. Local measures, including debridement, drainage, and sometimes excision, are the treatment for cutaneous infections, abscesses, and corneal infections. Although drug therapy has been ineffective, patients with pulmonary disease frequently recover spontaneously.
Treatment for partial tears of the lateral ligament of the ankle: a prospective trial.
Authors: S C Brooks, B T Potter, J B Rainey
Journal: BMJ (1981)

There is debate about the most appropriate form of treatment for partial tears of the lateral ligament of the ankle, which are common after inversion injuries. A prospective trial of four forms of treatment was carried out. The forms of treatment used were: no treatment with only a minimal bandage, Tubigrip support, immobilisation in plaster-of-Paris, and physiotherapy. The end point was taken when the patient returned to work or had a low score on an objective clinical scale. Early mobilisation, with or without physiotherapy, was found to offer the most rapid return to functional activity. Patients who had had their ankle immobilised in plaster-of-Paris required more days off work and longer attendance at a follow-up clinic. Inversion injuries are common and cause absence from work and discomfort for the patient. These findings suggest that mobilisation with physiotherapy, although not practical for all patients, is the most satisfactory course of treatment.
Belgium to subsidise costs of contraception to teenagers
Authors: R. Watson
Journal: BMJ (2003)

The Belgian government is planning to provide hundreds of thousands of teenagers with monthly vouchers from 1 January next year to help pay for the costs of contraception, in a bid to reduce the number of unwanted pregnancies.

Each voucher will be worth €3 (£2.1; $3.5)–the monthly cost of the second generation pill–and will be available to about …
Phase II Multicenter Trial of Voreloxin as Second-Line Therapy in Chemotherapy-Sensitive or Refractory Small Cell Lung Cancer
Authors: Lee M. Krug, Jeffrey Crawford, David S. Ettinger, Geoffrey I. Shapiro, David Spigel, Tony Reiman, Jennifer S. Temel, Glenn C. Michelson, Donald Y. Young, Ute Hoch, Daniel C. Adelman
Journal: Journal of Thoracic Oncology (2011)
Characterization of Der p 21, a new important allergen derived from the gut of house dust mites*
Authors: M. Weghofer, Y. Dall’Antonia, M. Grote, A. Stöcklinger, M. Kneidinger, N. Balic, M.‐T. Krauth, E. Fernández‐Caldas, W. R. Thomas, M. van Hage, S. Vieths, S. Spitzauer, F. Horak, D. I. Svergun, P. V. Konarev, P. Valent, J. Thalhamer, W. Keller, R. Valenta, S. Vrtala
Journal: Allergy (2008)

Background: The house dust mite (HDM) Dermatophagoides pteronyssinus is a major allergen source eliciting allergic asthma. The aim of the study was to identify new important HDM allergens associated with allergic asthma. Methods: A cDNA coding for a new mite allergen, designated Der p 21, was isolated using immunoglobulin E (IgE) antibodies from patients with allergic asthma out of a D. pteronyssinus expression cDNA library and expressed in Escherichia coli . Results: Circular dichroism analysis of the purified allergen showed that rDer p 21 (14 726 Da) is one of the few mite allergens with an α‐helical secondary structure. The protein exhibited high thermal stability and refolding capacity, and, as determined by small angle X‐ray scattering, formed a dimer consisting of two flat triangles. rDer p 21 bound high levels of patients’ IgE antibodies and showed high allergenic activity in basophil activation experiments. Rabbit anti‐Der p 21 IgG antibodies inhibited mite‐allergic patients’ IgE binding and allowed the ultrastructural localization of the allergen in the midgut (epithelium, lumen and faeces) of D. pteronyssinus by immunogold electron microscopy. Der p 21 revealed sequence homology with group 5 mite allergens, but IgE and IgG reactivity data and cross‐inhibition studies identified it as a new mite allergen. Conclusions: Der p 21 is a new important mite allergen which is liberated into the environment via faecal particles and hence may be associated with allergic asthma.
DERMATOLGICAL COMPLICATIONS OF B.C.G. VACCINATTON.
Authors: A. DOSTROVSKY, F. SAGHER
Journal: British Journal of Dermatology (1963)

British Journal of DermatologyVolume 75, Issue 5 p. 181-192 DERMATOLGICAL COMPLICATIONS OF B.C.G. VACCINATTON. A. DOSTROVSKY, A. DOSTROVSKY The Department of Dermatology and Venereology, Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this authorF. SAGHER, F. SAGHER The Department of Dermatology and Venereology, Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this author A. DOSTROVSKY, A. DOSTROVSKY The Department of Dermatology and Venereology, Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this authorF. SAGHER, F. SAGHER The Department of Dermatology and Venereology, Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this author First published: May 1963 https://doi.org/10.1111/j.1365-2133.1963.tb13547.xCitations: 36AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume75, Issue5May 1963Pages 181-192 RelatedInformation
Giving oxygen in acute myocardial infarction may raise death risk, Cochrane review concludes
Authors: S. Mayor
Journal: BMJ (2010)

A Cochrane systematic review has found no evidence that the routine practice of giving inhaled oxygen to patients with acute myocardial infarction is beneficial, and it may even increase mortality, it says. Its authors call for a large trial to be carried out urgently to provide a clear answer.

Oxygen is routinely given to patients with acute myocardial infarction, with clinical guidelines in most countries recommending its use in emergency care. The rationale is that this may improve oxygenation of the ischaemic myocardium and so reduce cardiac pain, infarct size, and consequent morbidity and mortality. However, previous studies have found insufficient evidence to determine whether oxygen had any …
Accuracy of Cord Blood Screening for Sickle Hemoglobinopathies
Authors: Michael S. Kramer
Journal: JAMA (1979)

The strategic advantages of neonatal diagnosis of sickle hemoglobinopathies depend on an accurate cord blood screening procedure. One hundred thirty-eight black children in whom a range of normal and abnormal hemoglobin genotypes was identified by agar gel and cellulose acetate hemoglobin electrophoresis at birth were retested by cellulose acetate three to five years later. The original cord blood diagnoses were verified in all 138, including all 26 with major sickle syndromes (SS, S-β thalassemia, and SC). Cord blood hemoglobin electrophoresis using these techniques permits accurate neonatal diagnosis of major and minor sickle hemoglobinopathies. (<i>JAMA</i>241:485-486, 1979)
Povidone-iodine antisepsis for transrectal prostatic biopsy.
Authors: M Rees, E C Ashby, R D Pocock, C H Dowding
Journal: BMJ (1980)

other factors that might influence uptake of rubella immunisation every girl in the control and intervention groups filled in a questionnaire, from which we established her age, family composition, and social class and discovered whether she had any knowledge about rubella and intended to accept immunisation.There was no significant difference between the control and intervention schools in any of these factors.One hundred and seventy-nine girls (19 °' ) had knowledge of rubella and 425 (45 %) said that they intended to accept immunisation.The table shows the numbers of girls immunised in the control and intervention groups.An uptake of 93 % was achieved overall in the intervention group compared with 75 % in the control group.This difference is significant (p <0-001).There was no significant difference between the girls immunised and not immunised as regards social class, family size and composition, or knowledge of rubella and intention to accept.Details are given elsewhere.2
Hepatitis B and exposure prone procedures
Authors: T. Delamothe
Journal: BMJ (1994)

for over two thirds of asthmatic children should influence long term studies of treatment.It is logical to study the efficacy of treatment in those at greater risk of persistent disease rather than in those who will probably grow out of their disease.Jenkins et al argue the benefits of treating children at higher risk, but the absence of substantiating evidence highlights the need for well controlled, long term studies of intervention in childhood asthma.These two longitudinal studies therefore yield essentially consistent outcomes: about two thirds of children will out grow their disease (especially those with mild asthma), while the third with more severe asthma will have persistent symptoms in adult life.Risk factors for persistence have been identified: the challenge now is to determine whether managing these "at risk" children more intensively alters the outcome.
A CASE OF RHIZOMELIC SPONDYLOSIS.
Authors: AUGUSTUS A. ESHNER
Journal: JAMA (1900)

The literature of the last few months abounds with the reports of a morbid condition that has been variously designated stiffness of the spinal column, chronic, progressive rigidity of the spinal column with ankylosis, ankylotic rigidity of the spinal column, ankylosing inflammation of the spinal column and of the large joints of the extremities, chronic ankylosing spondylitis, deforming spondylitis, spinal arthritis deformans, and rhizomelic spondylosis. The disorder is characterized essentially by increased posterior curvature, with lessened mobility, of the spinal column, often without, but sometimes with nerve-root symptoms, and. involvement also of other joints, particularly the large ones of the trunk. The fundamental lesion in the majority of cases is believed to consist in a proliferative and rarefying inflammatory process involving the vertebræ, the discs between, and the ligaments uniting, them. In some instances there is probably also meningitis, sometimes primary and sometimes associated or secondary. It appears that the
Use of Broad-spectrum Antibiotics
Authors: J. R. Cowhig
Journal: BMJ (1970)

B JOURNA sister's desk in a state of asphyxia.Unfortu- nately, despite all attempts at resuscitation, he had a cardiac arrest within ten minutes and failed to recover.Necropsy showed marked mediastinal emphysema, with some subcutaneous emphysema at the site of the operation.There was no possible source of this emphysema except from the wound.It seems most likely that the Yates drain allowed air to be aspirated into the wound on inspiration, particularly when the patient was lying in bed, and that expiration blocked the ends of the corrugated tubes, causing a ball-valve effect.This seems a potential risk of Yates drainage tubing which I think needs to be appreciated by all surgeons.-Iam, etc.,
EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma
Authors: Qi-Wen Fan, Christine K. Cheng, W. Clay Gustafson, Elizabeth Charron, Petra Zipper, Robyn A. Wong, Justin Chen, Jasmine Lau, Christiane Knobbe-Thomsen, Michael Weller, Natalia Jura, Guido Reifenberger, Kevan M. Shokat, William A. Weiss
Journal: Cancer Cell (2013)
Assessment of Perioperative Cardiac Risk
Authors: Lee Goldman
Journal: New England Journal of Medicine (1994)

About 10 percent of the U.S. population undergoes noncardiac surgery each year. Although the risk of a perioperative myocardial infarction with major surgery is only 1 to 2 percent in patients over the age of 40 years,1,2 the risk is higher in those who are older or have cardiovascular disease13. For example, in patients with well-controlled angina who undergo major vascular surgery, the risk of a perioperative myocardial infarction is 3 to 10 percent, and the risk of death from cardiac causes is 1 to 5 percent1,47.Several noninvasive cardiac tests, such as preoperative . . .