The Infancy of Immunotoxicity
Authors: ELIAS ABRUTYN
Journal: Annals of Internal Medicine (1979)

Editorial Notes1 January 1979The Infancy of ImmunotoxicityELIAS ABRUTYN, M.D.ELIAS ABRUTYN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-118 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDeficient immune response is well recognized as a manifestation of primary immunodeficiency syndromes or neoplastic diseases (in which it can be a consequence of radiation or cancer chemotherapy). The depressed immune responses make the host susceptible to two major complications, infection and tumor. Can alterations in the immune response also result from exposure to foods, drugs, or environmental contaminants? Are the altered immune responses associated with similar or other complications? The evidence summarized in a recent review (1) indicates that many substances in our environment have immunosuppressive properties, including lead, cadmium, the arsenicals, DDT, and some pesticides. Exposure to such...References1. VOS J: Immune suppression as related to toxicology. CRC Crit Rev Toxicol 5:67-101, 1977 CrossrefMedlineGoogle Scholar2. SCHWARTZ H: The effect of carrageenan on inflammation and immunity, in FDA Science Symposium IV. Inadvertent Modification of the Immune Response: The Effects of Foods, Drugs, and Environmental Contaminants. Annapolis, Maryland, 29 August 1978 [symposium paper] Google Scholar3. ARCHER D: Antioxidants and the immune response, in FDA Science Symposium IV. Inadvertent Modification of the Immune Response: The Effects of Foods, Drugs, and Environmental Contaminants. Annapolis, Maryland, 29 August 1978 [symposium paper] Google Scholar4. LUSTER M, MCLACHLAN J, and FAITH R: Immunological effects following in utero exposure to diethylstilbestrol in mice, in FDA Science Symposium IV. Inadvertent Modification of the Immune Response: The Effects of Foods, Drugs, and Environmental Contaminants. Annapolis, Maryland, 28 August 1978 [symposium paper] Google Scholar5. BEKESI J, ROBOZ J, FISCHBEIN A, ANDERSON H, SELIKOFF I, and HOLLAND J: Impaired immunological function of polybrominated biphenyls (PBB) in blood compartments of exposed Michigan dairy farmers and chemical workers, in FDA Science Symposium IV. Inadvertent Modification of the Immune Response: The Effects of Foods, Drugs, and Environmental Contaminants. Annapolis, Maryland, 30 August 1978 [symposium paper] Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ELIAS ABRUTYN, M.D.Affiliations: University of Pennsylvania School of Medicine Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOverview of the Immune System and ImmunotoxicologyOverview of the Immune System and ImmunotoxicologySafety Assessment Studies: ImmunotoxicityOverview of the Immune System and ImmunotoxicologyChapter 1 Definition, history, and scope of immunotoxicology 1 January 1979Volume 90, Issue 1Page: 118-119KeywordsCadmiumCancer chemotherapyDichlorodiphenyltrichloroethaneDrugsFoodImmune responseImmunodeficienciesImmunosuppressives ePublished: 1 December 2008 Issue Published: 1 January 1979 PDF downloadLoading ...