Hyperlipoproteinemia: Problems in Diagnosis and Challenges Posed by the "Type III" Disorder
Authors: RICHARD J. HAVEL
Journal: Annals of Internal Medicine (1975)

Editorials1 February 1975Hyperlipoproteinemia: Problems in Diagnosis and Challenges Posed by the "Type III" DisorderRICHARD J. HAVEL, M.D.RICHARD J. HAVEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-2-273 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe disorder most commonly called "type III hyperlipoproteinemia," also referred to as "broad beta," "floating beta disease," or "dysbetalipoproteinemia," has been of great fascination to investigators of the genetically determined disorders of lipid transport in the blood. This fascination relates both to its distinctive clinical features and to the unique very low density lipoprotein (VLD lipoprotein) that accumulates in blood plasma of affected individuals. The reports from Seattle and Bethesda in this issue (pp. 141-174) provide improved criteria for diagnosing the presence of the mutant gene as well as evidence that it may be transmitted as an autosomal Mendelian dominant....References1. HAVEL R: Pathogenesis, differentiation and management of hypertriglyceridemia, in Advances in Internal Medicine, vol. 15, edited by STOLLERMAN GH. Year Book Medical Publishers, Inc., 1969, pp. 117-154 Google Scholar2. HAZZARDPORTEBIERMAN WDE: Abnormal lipid composition of very low density lipoproteins in diagnosis of broad-beta disease (type III hyperlipoproteinemia). Metabolism 21:1009-1019, 1972 CrossrefMedlineGoogle Scholar3. GODOLPHINCONRADICAMPBELL WGD: Type III hyperlipoproteinaemia in a child. Lancet 1:209-210, 1972 CrossrefMedlineGoogle Scholar4. SATAHAVELJONES TRA: Characterization of subfractions of triglyceride-rich lipoproteins separated by gel chromatography from blood serum of normolipemic and hyperlipemic humans. J Lipid Res 13:757-768, 1972 CrossrefMedlineGoogle Scholar5. HAVELKANE RJ: Primary dysbetalipoproteinemia: predominance of a specific apoprotein species in triglyceride-rich lipoproteins. Proc Natl Acad Sci USA 70:2015-2019, 1973 CrossrefMedlineGoogle Scholar6. HAZZARDPORTEBIERMAN WDE: Abnormal lipid composition of chylomicrons in broad-β disease (type III hyperlipoproteinemia). J Clin Invest 49:1853-1858, 1970 CrossrefMedlineGoogle Scholar7. MJØSFAERGEMANHAMILTON OOR: Characterization of "remnants" of lymph chylomicrons and lymph and plasma very low density lipoproteins in "supradiaphragmatic" rats. Eur J Clin Invest 4:382-383, 1974 Google Scholar8. SHORESHOREHART VBR: Changes in apolipoproteins and properties of rabbit very low density lipoproteins on induction of cholesteremia. Biochemistry 13:1579-1585, 1974 CrossrefMedlineGoogle Scholar9. MAHLEYWEISGRABERINNERARITY RKT: Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia. Circ Res, 1974. In press Google Scholar10. HALLBILHEIMERPHAIR MDR: A mathematical model for apoprotein kinetics in normal and hyperlipemic patients (abstract). Circulation 50(suppl 3):114, 1974 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cardiovascular Research Institute School of Medicine University of California San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFamilial Dysbetalipoproteinemia: New Aspects of Pathogenesis and DiagnosisWhat Is β-VLDL?Evaluation of the classical methods for the diagnosis of type III hyperlipoproteinemiaType III hyperlipoproteinemia in adolescentsThe composition of low (LDL) and very low (VLDL) density lipoprotein subfractions in type III hyperlipoproteinaemia: Comparison with normal subjectsType III hyperlipoproteinemia: A comparative study of current diagnostic techniquesPediatric familial type III hyperlipoproteinemiaLipoprotein fractionation by a precipitation method. a simple quantitative procedureDelayed clearance of chylomicron remnants following vitamin-A-containing oral fat loads in broad-β disease (type III hyperlipoproteinemia)Primary hyperlipoproteinemia in xanthomatosisThe Genetic Hyperlipidemias 1 February 1975Volume 82, Issue 2Page: 273-274KeywordsBloodBlood plasmaGenetic diseasesLipidsLipoproteinsVery low density lipoprotein Issue Published: 1 February 1975 PDF DownloadLoading ...