tbuckley/cabot-search huggingface dataset:
Veneers of Venereal Disease
Authors: George R. Wagner
Journal: JAMA (1965)

<h3>To the Editor:—</h3> I would like to comment on Dr. Pflum's letter concerning the declining morals and rise in incidence of venereal disease. I agree that the main treatment lies more intrinsically (proper use of will power) than extrinsically (doctor's advice, campaigns, penicillin, fears, threats, etc). Being a public health doctor and private practicing pediatrician, I have no doubt that the incidence will get much worse. As the responsibility resulting from sexual intercourse is lessened via birth control dissemination, and as the stigma of homosexuality is neutralized by describing it as the "fulfilled desires by mutual consent in adults," the rate of venereal pleasures can only increase and with it bring an increased incidence of venereal disease. My observations of the children themselves, and what they say, reflect a drastic change since my high school days (1937-1939) and the present group of students. It is my firm conviction that the
Endothelial Cell Loss and Graft Survival after Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty
Authors: Marcus Ang, Jodhbir S. Mehta, Fiona Lim, Saideep Bose, Hla Myint Htoon, Donald Tan
Journal: Ophthalmology (2012)
Angiotensin II increases electrical coupling in mammalian ventricular myocardium.
Authors: K Hermsmeyer
Journal: Circulation Research (1980)

Electrical measurements of current flow in ventricular myocardium immersed in silicone oil showed that angiotensin II increases the cell-to-cell spread of current within seconds. The increases in current spread and conduction velocity occur without any changes in resting membrane potential or maximum rate of rise of the action potential. The concentration range was 10 nM to 10 microM, with an ED50 of 100 nM for angiotensin exposures lasting about 10 seconds. The larges effects were an apparent decrease in resistance through the cellular pathway to 50% of control and a 40% increase in conduction velocity, which returned to control in about 15 minutes. Continuous or repeated exposure to angiotensin caused desensitization to appear. These effects were found with or without denervation by 6-hydroxydopamine and beta-adrenergic blockade by 1 microM propranolol in calf, pig, sheep, and rabbit ventricular myocardium. Therefore, angiotensin appears to increase electrical conduction rapidly and directly in cardiac muscle by decreasing resistance through the cellular pathway.
Fatherhood as a Component of Men's Health
Authors: Craig F. Garfield, Elizabeth Clark-Kauffman, Matthew M. Davis
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Rapid Metabolic Screening Test to Evaluate Potential Cadaveric Kidney Donors
Authors: R. B. Smith, P. I. Terasaki, D. C. Martin
Journal: JAMA (1967)

A tetrazolium dye reduction test has been evaluated for use in assessing the suitability of cadaver kidneys for transplantation. The time required for a color change of a small cortical slice was measured. Nine human cadaveric kidney transplants were tested and the results generally paralleled the severity of the acute tubular necrosis present. In a simulated cadaver experiment with canine kidneys subjected to varying periods of ischemia, the tetrazolium test could identify kidneys which would not recover function. Its greatest potential value appears to be in the utilization of kidneys previously thought unsuitable. A favorable test result in a donor kidney which was subjected to 48 hours of severe shock and 36 hours of total anuria which was unresponsive to mannitol, resulted in a successful transplantation to a recipient who otherwise might have been denied a kidney.
Israeli health ministry lambasted for negligence over medical experiments
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2005)

Thousands of Israelis, from infants to demented old people, have in recent years been included in illegal medical experiments, some without informed consent being given by the patient or his or her parent or guardian, as required by the 1964 Declaration of Helsinki.

This was disclosed by Eliezer Goldberg, Israel's state comptroller, in his semi-annual report monitoring the functions of public bodies. The comptroller severely criticised the health ministry for negligence and carelessness in supervising hospitals' clinical trials, some of which involved potentially harmful invasive tests and treatments.

He also lambasted the ministry for spending eight years preparing a government …
Lumbar puncture in spontaneous subarachnoid hemorrhage.
Authors: P J Teddy, M Briggs, C B Adams
Journal: BMJ (1983)

in either site the deconjugated bile salts might be acting on the colon to produce microscopic colitis and diarrhoea.The patient underwent cholecystectomy, and although no organisms could be isolated from either the gall bladder or bile duct bile both her diarrhoea and the histological abnormality of the rectal mucosa remitted and have not recurred over the ensuing two years.This case suggests that gall stones may be one cause of microscopic colitis, and we would be most interested to know whether any of the cases reported by Dr Kingham and others also had gall stones.
Scorecard Medicine—Measuring Process and Outcome
Authors: Stephen Clement
Journal: Annals of Internal Medicine (1994)

Letters1 June 1994Scorecard Medicine—Measuring Process and OutcomeStephen Clement, MDStephen Clement, MDMajor, Medical Corp; Department of the Army; Walter Reed Army Medical Center; Washington, DC 20307-5001Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-11-199406010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Brook's editorial [1] and the accompanying article advocate the increased public release of patient outcome data to monitor quality of care. As noted, such a system of scorecard medicine would supposedly answer the question “Do the patients of physician A do better, after controlling for sickness, than those of physician B?”I immediately thought of five patients in the past week who would probably score low in the “sickness” category but who epidemiologically are at high risk for early death. All are middle-aged men and women with a strong family history of coronary artery disease, hypertension, ...References1. Brook RH. Health care reform is on the way: Do we want to compete on quality? Ann Intern Med. 1994; 120:84-6. Google Scholar2. Topol EJ, Califf RM. Scorecard cardiovascular medicine: its impact and future directions. Ann Intern Med. 1994; 120:65-70. Google Scholar3. Lichtman SW, Pisarska K, Berman ER, Pestone M, Dowling H, Offenbacher E, et al. Discrepancy between self-reported and actual caloric intake and exercise in obese subjects. N Engl J Med. 1992; 327:1893-8. Google Scholar4. Fulop G, Reinhardt J, Strain JJ, Paris B, Miller M, Fillit H. Identification of alcoholism and depression in a geriatric medicine outpatient clinic. J Am Geriatr Soc. 1993; 41:737-41. Google Scholar5. Sobolski JC, Kolesar JJ, Kornitzer MD, De Backer GG, Mikes Z, Dramaix MM, et al. Physical fitness does not reflect physical activity patterns in middle-aged workers. Med Sci Sports Exerc. 1988; 20:6-13. Google Scholar Author, Article, and Disclosure InformationAuthors: Stephen Clement, MDAffiliations: Major, Medical Corp; Department of the Army; Walter Reed Army Medical Center; Washington, DC 20307-5001Disclaimer: The opinions and assertions stated here are those of the author and do not represent the views of the Department of the Army or the Department of Defense. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1994Volume 120, Issue 11Page: 971-972KeywordsExerciseHealth care qualityObesityPatient advocacyPatientsPhysical fitnessStable coronary artery diseaseSuicideSurgeonsType 2 diabetes ePublished: 15 August 2000 Issue Published: 1 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
REQUIREMENTS FOR ADMISSION TO MEDICAL COLLEGES.
Authors: E. A. de SCHWEINITZ
Journal: JAMA (1903)

A man who has not had a biologic training may become an excellent physician, although he will have to work harder to make up deficiencies. Some of the biologic work if not possessed by the student on entrance might well be included in the first year's course. It would certainly be a great advantage if more comparative work was required throughout the regular medical course. This could often well be done by eliminating some of the special studies which are properly post-graduate. In fact, the entire medical course could be remodeled to advantage. It is not the business of a medical school to graduate specialists, nor is it the business of a medical school to make the course of such a character that only a few can succeed in accomplishing the required work. We should give to each student a good, general, solid ground-work and afford him an opportunity to
Etiology of Traumatic Amputations in Children
Authors: George T. Aitken
Journal: New England Journal of Medicine (1961)

INCREASING mechanization of the environment in which people and their children live has resulted in increased exposure to the factors that may produce injuries resulting in loss of extremities. Classically, amputation is a surgical procedure that is considered to be a problem primarily of the adult population of the world and associated especially with war, peripheral vascular insufficiency and major industrial trauma. Experience gained in a children's amputation service has indicated that a relatively large number of children are also being exposed to the traumatic experiences that may result in amputation.Over a period of twelve years, this clinic has . . .
Yohimbine Challenge in Children With Anxiety Disorders
Authors: Floyd R. Sallee, Gopalan Sethuraman, Lauren Sine, Hong Liu
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: The authors evaluated the neurohormonal and subjective mood response of children with anxiety disorders who were challenged with yohimbine. METHOD: Seventeen children with DSM-IV diagnoses of anxiety disorders and 15 normal comparison children were given yohimbine orally (0.1 mg/kg). Neurohormonal measures and visual analog self-reports of tenseness were recorded over a 150-minute period. RESULTS: Yohimbine was uniformly well tolerated, and it behaviorally differentiated children with anxiety disorders from normal comparison children with higher maximum change (Δmax) ratings of anxiety in the patients (mean=17.4 mm, SD=29.8) than in the comparison subjects (mean=0.3 mm, SD=4.4). Yohimbine-stimulated Δmax growth hormone (GH) for children with anxiety disorders (mean=–1.5 ng/ml, SD=5.9) was significantly reduced compared to that of normal comparison children (mean=2.7 ng/ml, SD=4.5). CONCLUSIONS: Yohimbine selectively elevates self-rated anxiety in children with anxiety disorders and is associated with the blunting of GH in those children relative to that of comparison children. Presence of a blunted GH response to yohimbine in children with anxiety disorders is reminiscent of findings in adults with anxiety disorders, particularly panic disorder. These findings support enhanced central adrenergic sensitivity in children with anxiety disorders, as demonstrated by yohimbine-exacerbated anxiety. The findings should be reconciled with the absence of clonidine-related GH blunting in the same cohort.
Acute Leukemia in Pregnancy
Authors: Martin Newcomb, Lodouico Balducci, J. Tate Thigpen, Francis S. Morrison
Journal: JAMA (1978)

ACUTE leukemia is not rare in adults of reproductive age. With the advent of increasingly effective chemotherapeutic regimens, 62% of patients with leukemia from 20 to 34 years of age can be expected to obtain complete remission. The median anticipated length of survival presently exceeds 60 weeks, and we hope this will improve rapidly.<sup>1</sup>Therefore, the management of leukemia during pregnancy will require increasing attention. Management decisions are difficult, and data are sparse. One important consideration is the potential effect of chemotherapy on the fetus. Two women received intensive chemotherapy and achieved remission while carrying pregnancies to term. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 22-year-old woman, gravida 2 and para 1, was admitted to the University Hospital on Sept 14, 1973, with a three-week history of increasing weakness and melena. She was approximately four months pregnant according to history. At the time of admission, she had a temperature of 38.7
Successful pregnancy in chronic renal failure
Authors: R A Coward, P. Mallick
Journal: BMJ (1980)

prognosis, must naturally always take prece- dence over a desire to improve the mortality rate.For all these various reasons we would like to end with a plea that future investigations into the effectiveness of neonatal intensive care undertaken before 1975 should in parLicular focus on the outcome of the low birthweight group 1500-1999 g.Certainly infants of less than 1000 g are best excluded or dealt with separately.
Germline gain-of-function mutations in SOS1 cause Noonan syndrome
Authors: Amy E Roberts, Toshiyuki Araki, Kenneth D Swanson, Kate T Montgomery, Taryn A Schiripo, Victoria A Joshi, Li Li, Yosuf Yassin, Alex M Tamburino, Benjamin G Neel, Raju S Kucherlapati
Journal: Nature Genetics (2006)
Orbital Cerebrospinal Fluid Space in Glaucoma: The Beijing Intracranial and Intraocular Pressure (iCOP) Study
Authors: Ningli Wang, Xiaobin Xie, Diya Yang, Junfang Xian, Yong Li, Ruojin Ren, Xiaoxia Peng, Jost B. Jonas, Robert N. Weinreb
Journal: Ophthalmology (2012)
Glomerular macrophages express augmented procoagulant activity in experimental fibrin-related glomerulonephritis in rabbits.
Authors: P G Tipping, M G Lowe, S R Holdsworth
Journal: Journal of Clinical Investigation (1988)

Glomerular fibrin deposition and augmentation of procoagulant activity (PCA) are dependent on glomerular macrophage infiltration in anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM GN) in rabbits. Expression of PCA on the surface of glomerular macrophages and/or augmentation of intrinsic glomerular cell PCA by macrophage cytokines (such as IL 1) are potential mechanisms by which macrophages may augment glomerular PCA. Macrophages were isolated from glomeruli of rabbits developing anti-GBM GN to measure their PCA expression. These macrophages were characterized by morphological and functional criteria. Glomerular macrophages expressed markedly augmented PCA (2.8 +/- 0.7 mU/10(3) cells) compared with blood monocytes (0.05 +/- 0.02 mU/10(3) cells) and alveolar macrophages (0.09 +/- 0.02 mU/10(3) cells) from the same rabbits. Glomerular macrophage PCA was functionally identical to the PCA of whole glomeruli, and was consistent with that of tissue factor. Supernatants from nephritic glomeruli contained IL 1 bioactivity and augmented endothelial cell PCA in vitro. However, these supernatants and purified IL 1 failed to augment the PCA of normal and macrophage-depleted nephritic glomeruli. These studies demonstrate that, in this model of anti-GBM GN, glomerular macrophages contribute directly to the augmented glomerular PCA by their expression of surface membrane PCA, and have the potential to indirectly augment glomerular PCA by their production of cytokines capable of enhancing endothelial cell PCA.
Immune cells from pleural fluids of patients with inflammatory breast cancer are immunocompetent.
Authors: EN Cohen, C Jimenez, H Gao, B Lee, C Li, S Krishnamurthy, WA Woodward, E Andreopoulou, DL Bethancourt, GN Hortobagyi, M Cristofanilli, JM Reuben
Journal: Cancer Research (2009)

Abstract Abstract #5044 Background: Malignant pleural effusion is a debilitating complication of metastatic breast cancer (MBC), including inflammatory breast cancer (IBC). The cellular components in pleural effusion are important indicators of pathologic process. Although pleural fluids from patients with IBC contain tumor cells and immune cells, little is known about the phenotype and function of the immune cell infiltrate. The objective of the study was to determine the immunophenotype and function of the cellular immune cells in pleural effusion of patients with pleural metastases.&amp;#x2028; Methods and Patients: Pleural effusions from 9 women with MBC, 6 with IBC, median age 56 years (range 44-75 yrs), were submitted for pathological review. Mononuclear cells (MNC) were reacted with a cocktail of monoclonal antibodies to detect surface antigens by 8-parameter flow cytometry. In addition, MNC were activated through the T-cell receptor (TCR) with immobilized anti-CD3 and soluble anti-CD28 to assess intracytoplasmic syntheses of pro-inflammatory [interleukin (IL)-2, tumor necrosis factor (TNF)-a and interferon-gamma (IFN-γ)] and anti-inflammatory (IL-10) cytokines by TCR-activated CD4+ and CD8+ T cells. Data are presented as the mean (±SEM) of TCR-activated CD4+ and CD8+ T-cells that synthesized inflammatory and anti-inflammatory cytokines.&amp;#x2028; Results: Upon pathological review, the mean (±SEM) number of tumor cells, MNC, and neutrophils were 20.2% ± 7.4% (range, 2%-72%), 62.4% ± 7.7% (range, 25%-96%), and 17.3% ± 5.9% (range, 0%-50.0%), respectively. The MNC consisted of 83.1% ± 8.2% CD3+ pan-T, 58.2% ± 7.0% CD4+ T, 24.2% ± 5.2% CD8+ T, 2.8% ± 0.9% CD19+ B, 4.0% ± 0.7% natural killer (NK), 3.4% ± 1.8% NKT, and 0.9% ± 0.2% dendritic cells, respectively. The CD4/CD8 T-cell ratio was 3.62 ± 0.78. The percentages of CD4+ and CD8+ T cells that synthesized inflammatory and anti-inflammatory cytokines following activation through the TCR-activated are listed in Table 1.&amp;#x2028; &amp;#x2028; Conclusion: There were no statistically significant differences between pleural fluids of IBC and non-IBC subjects with respect to tumor cell involvement, MNC phenotype, or T-cell function. Moreover, the function of pleural fluid T cells of MBC patients were similar to that of normal peripheral blood T cells (historical data, not shown). These data suggest that T-cells in the pleural fluids of patients with MBC are immune competent and can be activated through the TCR to synthesize pro- and anti-inflammatory cytokines. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5044.
Abstract 3355: Comparison of CD133, uPAR, and CXCR4 expression in lung cancer cell lines under normal and spheroid culture conditions
Authors: Alan J. Lee, Sami Sarfaraz, Donna M. Voeller, Giuseppe Giaccone
Journal: Cancer Research (2010)

Abstract Background: Cancer stem cells (CSC) have been identified in several solid tumors including breast, brain, and recently lung cancers, etc. In the CSC model, CSCs are thought to be able to self-renew extensively, grow as spheroids in vitro, and be resistant to conventional cancer therapies. CD133, uPAR and CXCR4 have been reported as putative markers that can be used to mark enriched cancer stem cell populations. Although CD133, uPAR and CXCR4 have been implicated in CSC biology and identification, their application as lung CSC (LCSC) markers have not been fully explored. In this study we examined and compared CD133, uPAR and CXCR4 expression in non-spheroid cells and CSC-like spheroid cells derived from several lung and non-lung cancer cell lines. Methods: We cultured four classic small cell lung cancer (SCLC) lines, two variant SCLC lines, three non-small cell lung cancer (NSCLC) lines, one primary lung cancer line derived in our lab, three lymphoma cell lines, one thymoma cell line, and one breast cancer cell line. Cell lines were maintained in RPMI or DMEM with 10% fetal calf serum. Spheroids were cultured and maintained in low-attachment flasks in serum free media supplemented with EGF and FGF. CD133, CXCR4, and uPAR expression were evaluated by immunostaining followed by flow cytometry analysis. Results: Under spheroid culture conditions, CD133 expression tends to remain the same or increases in most of the cell lines tested. SCLC and lymphoma lines tend to express more CD133 than NSCLC and non-lung cancer lines in both normal and spheroid culture conditions. uPAR expression is generally low, however when detectable, it only shows up in cell lines grown in spheroid culture conditions. CXCR4 expression generally increases in spheroid culture conditions with greater expression seen in SCLC lines and lymphoma lines. Conclusion: Spheroid cells tend to exhibit higher CD133 expression than cells under regular culture conditions. This finding supports the idea that CD133 is enriched in LCSC populations. SCLC and lymphoma lines in normal and spheroid culture conditions express more CD133, uPAR, and CXCR4. This does not appear to be tied to adherent growth properties as two adherent SCLC lines displayed no striking difference in expression compared with other non-adherent SCLC lines. However the tendency for SCLC cells and lymphoma cells to grow in regular culture conditions as clumps may offer some insight into the increased expression of these markers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3355.
Pathologist in G20 demonstration death is suspended for "irresponsible" conduct in earlier case
Authors: C. Dyer
Journal: BMJ (2011)

Freddy Patel, the pathologist who wrongly concluded that the first victim of the “Camden Ripper” had died of a heart attack during consensual sex, has been suspended from the UK medical register for four months.

The General Medical Council was told that Dr Patel’s “irresponsible” conduct of postmortem examinations on the body of 31 year old prostitute Sally White in 2002 might have hampered the police investigation into the activities of Anthony Hardy, who went on to kill two other women in Camden, north London.

The case was not concerned with Dr Patel’s role in the investigation into …
CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to γ-secretase inhibitors
Authors: T Palomero, K C Barnes, P J Real, J L Glade Bender, M L Sulis, V V Murty, A I Colovai, M Balbin, A A Ferrando
Journal: Leukemia (2006)