tbuckley/cabot-search huggingface dataset:
Quebec proposes to ban women over 42 from having IVF
Authors: O. Dyer
Journal: BMJ (2014)

<h3>Objective.</h3> Patients with ankylosing spondylitis (AS) can suffer concurrently from inflammatory bowel disease (IBD), as ulcerative colitis (UC) or Crohn’s disease (CD). Serological markers have been described to diagnose IBD. We investigated IBD serological markers in AS patients without IBD and whether these antibodies enable differentiating patients with AS and IBD from those without IBD. <h3>Methods.</h3> Frequencies of perinuclear antineutrophil cytoplasmic antibodies (pANCA), antibodies to the cell-wall mannan of <i>Saccharomyces cerevisiae</i> (ASCA), and antibodies to porin protein C of <i>Escherichia coli</i> (OmpC) were evaluated in 179 patients: 52 with AS, 50 with UC, 51 with CD, and 26 with IBD and AS. Patient groups were matched for age and sex. All AS patients fulfilled the 1984 modified New York criteria. IBD was ascertained by clinical, endoscopic, and microscopic findings. <h3>Results.</h3> In 55% of the AS patients without manifest IBD at least one antibody associated with IBD was observed. pANCA, ASCA (IgA and/or IgG), and OmpC antibodies were found in 21%, 30%, and 19% of the AS patients, respectively. pANCA was more frequently present in AS with concurrent UC than in AS alone (OR 8.2, 95% CI 1.2–55.6), thus being an indicator for UC in AS patients. <h3>Conclusion.</h3> Antibodies associated with IBD are detectable in more than half of AS patients without symptoms or signs of IBD. A relatively recent marker in this setting, OmpC antibodies, does not contribute to the differentiation between AS and type of IBD. Presence of pANCA, however, is significantly increased in AS patients who also have UC, and is an indicator to perform endoscopy. These results corroborate a pathophysiological link between AS and IBD.
Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group
Authors: Jason N. Berman, Robert B. Gerbing, Todd A. Alonzo, Phoenix A. Ho, Kristen Miller, Craig Hurwitz, Nyla A. Heerema, Betsy Hirsch, Susana C. Raimondi, Beverly Lange, Janet L. Franklin, Alan Gamis, Soheil Meshinchi
Journal: Leukemia (2011)
Left Ventricular Diastolic Filling Performance in Older Male Athletes
Authors: Jerome L. Fleg, Edward P. Shapiro, Frances O'Connor, Jean Taube, Andrew P. Goldberg, Edward G. Lakatta
Journal: JAMA (1995)

To determine whether older men who have undergone intensive endurance training over many years demonstrate less age-associated impairment of early diastolic left ventricular (LV) filling performance than their sedentary peers.Cross-sectional prospective study.Community-dwelling research volunteers.Sixteen older competitive male endurance athletes aged 52 through 76 years and 17 young (< 40 years) and 23 older (52 through 76 years) sedentary control subjects from the Baltimore Longitudinal Study of Aging.All subjects underwent resting Doppler echocardiography and determination of maximal aerobic capacity (VO2max) during graded treadmill exercise. Doppler echocardiographic studies were interpreted without knowledge of the subject's age or exercise habits.Doppler-derived measures of LV diastolic filling performance: peak early (E) filling velocity, peak late (A) filling velocity, ratio of peak E to peak A velocities (E/A), and atrial filling fraction.Older athletes demonstrated higher VO2max (47 +/- 6 mL/kg per minute [mean +/- SD]) than either the young controls (41 +/- 7 mL/kg per minute) or older controls (30 +/- 7 mL/kg per minute) (P < .05) as evidence of their superior conditioning status. However, peak E diastolic LV filling velocity was higher in young controls (79 +/- 17 cm/s) than in older athletes (56 +/- 15 cm/s) or older controls (68 +/- 18 cm/s) (P < .001). This age difference persisted after normalizing peak E velocity for mitral stroke volume. Peak E/A ratio and atrial filling fraction were also similar in older athletes (1.2 +/- 0.5 and 0.41 +/- 0.1, respectively) and older controls (1.1 +/- 0.4 and 0.41 +/- 0.1, respectively), and differed significantly from corresponding values of 1.7 +/- 0.4 and 0.33 +/- 0.1 in young controls (P < .001 and P < .05, respectively). By multiple regression analysis, age but not treadmill VO2max was a significant predictor of peak E velocity, peak A velocity, peak E/A ratio, and atrial filling fraction.Older men with a long history of intensive endurance training demonstrate impaired early diastolic LV filling similar to that of their sedentary peers. Thus, impairment of early diastolic filling appears to be intrinsic to normative aging and not secondary to the reduction in aerobic capacity that accompanies the aging process.
Dear Doctor... Regarding Calcium Channel Blockers-Reply
Authors: Daniel B. Stryer, Peter Lurie, Lisa A. Bero
Journal: JAMA (1996)

<h3>In Reply.</h3> —On August 19, 1995, I was asked by a public relations firm to compose a letter to respond to the forthcoming publication of the article by Dr Psaty and colleagues.<sup>1</sup>Having been greatly disturbed by the one-sided, sensational handling by the press of the oral report of these data in March 1995, I readily agreed to do so. As I explained to Dr Lurie when he called on September 11,1995,I did not ask who was sponsoring the letter and only later discovered that it was Bayer Corporation. I neither asked for nor received any compensation. I was assured that if there was a need for identification of corporate sponsorship, it would be included. I regret that the corporate sponsorship was not included but I stand by every word of my letter. My letter was not "misleading because it omitted pertinent information and other evidence calling the safety
Transnasal gastroscopy--lesson from a plumber
Authors: I. Tiwari
Journal: BMJ (2009)

Transnasal oesophagogastroduodenoscopy (OGD) is a new technique for upper gastrointestinal endoscopy using a thinner endoscope passed through the nose rather than the traditional route through the mouth. These endoscopes are about 6 mm in diameter, similar to a bronchoscope. We have been using this method since July 2007. Because of its …
Emerging role of microRNAs in lipid metabolism
Authors: Zhihong Yang, Tyler Cappello, Li Wang
Journal: Acta Pharmaceutica Sinica B (2015)

microRNAs (miRNAs or miRs) are small non-coding RNAs that are involved in post-transcriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of miRNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulation of miRNAs expression. We emphasized on several representative miRNAs that are functionally involved into lipid metabolism, including miR-33/33⁎, miR122, miR27a/b, miR378/378⁎, miR-34a and miR-21. Understanding the function of miRNAs in lipid homeostasis may provide potential therapeutic strategies for fatty liver disease.
Translocation Affecting Sonic Hedgehog Genes in Basal-Cell Carcinoma
Authors: Natalia Gomez-Ospina, Anne Lynn S. Chang, Kun Qu, Anthony E. Oro
Journal: New England Journal of Medicine (2012)

The sonic hedgehog (SHH) pathway is activated in basal-cell carcinoma, and loss-of-function mutations in SHH cause holoprosencephaly. This study uncovers a translocation involving the SHH promoter in a person with holoprosencephaly and basal-cell carcinomas.
Crimson Crescents—A Possible Association with the Chronic Fatigue Syndrome
Authors: Burke A. Cunha
Journal: Annals of Internal Medicine (1992)

Letters15 February 1992Crimson Crescents—A Possible Association with the Chronic Fatigue SyndromeBurke A. Cunha, MDBurke A. Cunha, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-4-347_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Approximately 80% of patients with the chronic fatigue syndrome, as defined by the Centers for Disease Control (1-3), seen in the Winthrop-University Hospital Chronic Fatigue Syndrome Center, have a peculiar purplish discoloration of both anterior pharyngeal pillars. The crescents are an intense crimson color and are well demarcated along the margins of both anterior pharyngeal pillars. They are not associated with pharyngitis or discoloration of the posterior pharyngeal pillars or uvula or accompanied by either anterior or posterior cervical adenopathy. In patients without tonsils, the crimson crescents assume a posterior position in the oropharynx. This appearance is...References1. Komaroff A and Buchwald D. Symptoms and signs of chronic fatigue syndrome. Rev Infect Dis. 1991;13(Suppl 1):8-11. CrossrefMedlineGoogle Scholar2. Holmes G. Defining the chronic fatigue syndrome. Rev Infect Dis. 1991;13(suppl 1):53-5. CrossrefMedlineGoogle Scholar3. Klein N and Cunha B. Chronic fatigue syndrome. Infect Dis Practice. 1991;15:1-7. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Burke A. Cunha, MDAffiliations: Winthrop-University Hospital Mineola, NY 11501 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInitiating Care of a Patient With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)Nose and MouthCorrections: Crimson Crescents—A Possible Association with the Chronic Fatigue SyndromeB.A. Cunha, MD 15 February 1992Volume 116, Issue 4Page: 347-347KeywordsChronic fatigue syndromeOropharynxPharyngitisTonsils ePublished: 1 December 2008 Issue Published: 15 February 1992 PDF downloadLoading ...
Samuel Freeman Miller, M.D
Authors: Aaron Hardy Ulm
Journal: New England Journal of Medicine (1957)

MOST presidents have wasted no time in filling an empty seat on the United States Supreme Court. Some pundits think that Lincoln took his time in appointing new judges because he hoped to offer the appointments to repentant Southerners. Since it took a long, hard war to make the Southerners repent, Lincoln finally nominated three deserving Republicans to a depleted Court.One prize went to his old courthouse friend, Judge Davis, who had managed Lincoln's campaign for the Presidency, and was certainly deserving of high reward. The second appointment went to a former Kentucky country doctor, Samuel Freeman Miller.Miller, . . .
Coumarin necrosis induced by renal insufficiency
Authors: C. Muniesa, J. Marcoval, A. Moreno, S. Gimenez, J. Sanchez, J.R. Ferreres, J. Peyri
Journal: British Journal of Dermatology (2004)

Journal Article Coumarin necrosis induced by renal insufficiency Get access C. Muniesa, C. Muniesa Departments of Dermatology and Anatomopathology, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Barcelona, Spain C.Muniesa. E‐mail: cristinamuniesa@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar J. Marcoval, J. Marcoval Departments of Dermatology and Anatomopathology, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar A. Moreno, A. Moreno Departments of Dermatology and Anatomopathology, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar S. Giménez, S. Giménez Departments of Dermatology and Anatomopathology, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar J. Sánchez, J. Sánchez Departments of Dermatology and Anatomopathology, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar J.R. Ferreres, J.R. Ferreres Departments of Dermatology and Anatomopathology, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar J. Peyrí J. Peyrí Departments of Dermatology and Anatomopathology, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 2, 1 August 2004, Pages 502–504, https://doi.org/10.1111/j.1365-2133.2004.06121.x Published: 01 August 2004 Article history Accepted: 16 February 2004 Published: 01 August 2004
Contrasting Signatures of Population Growth for Mitochondrial DNA and Y Chromosomes among Human Populations in Africa
Authors: Maya Metni Pilkington, Jason A. Wilder, Fernando L. Mendez, Murray P. Cox, August Woerner, Thiep Angui, Sarah Kingan, Zahra Mobasher, Chiara Batini, Giovanni Destro-Bisol, Himla Soodyall, Beverly I. Strassmann, Michael F. Hammer
Journal: Molecular Biology and Evolution (2007)

A history of Pleistocene population expansion has been inferred from the frequency spectrum of polymorphism in the mitochondrial DNA (mtDNA) of many human populations. Similar patterns are not typically observed for autosomal and X-linked loci. One explanation for this discrepancy is a recent population bottleneck, with different rates of recovery for haploid and autosomal loci as a result of their different effective population sizes. This hypothesis predicts that mitochondrial and Y chromosomal DNA will show a similar skew in the frequency spectrum in populations that have experienced a recent increase in effective population size. We test this hypothesis by resequencing 6.6 kb of noncoding Y chromosomal DNA and 780 basepairs of the mtDNA cytochrome c oxidase subunit III (COIII) gene in 172 males from 5 African populations. Four tests of population expansion are employed for each locus in each population: Fu's Fs statistic, the R(2) statistic, coalescent simulations, and the mismatch distribution. Consistent with previous results, patterns of mtDNA polymorphism better fit a model of constant population size for food-gathering populations and a model of population expansion for food-producing populations. In contrast, none of the tests reveal evidence of Y chromosome growth for either food-gatherers or food-producers. The distinct mtDNA and Y chromosome polymorphism patterns most likely reflect sex-biased demographic processes in the recent history of African populations. We hypothesize that males experienced smaller effective population sizes and/or lower rates of migration during the Bantu expansion, which occurred over the last 5,000 years.
New international guidelines on resuscitation
Authors: P. Morley
Journal: BMJ (2010)

Based on extensive review of the literature with important implications for practice

The most extensive review of the resuscitation literature ever attempted was published on 18 October.1 The review was performed by the International Liaison Committee on Resuscitation,2 and it was based on 277 specific questions about resuscitation; the answers were drawn from 411 systematic reviews.3 The newly released resuscitation guidelines of various organisations throughout the world, including those of the European Resuscitation Council (ERC) and the American Heart Association (AHA),4 5 are based on this information⇓.



Annabella Bluesky/Science Photo Library

Many of the recommendations made in the 2010 ERC guidelines remain unchanged, either because no new studies have been published or because evidence since 2005 supports what was previously available. There are several new recommendations, however, that have practical implications.

Chest compressions combined with rescue breaths remain the method of choice for cardiopulmonary resuscitation (CPR). However, “chest compression only” CPR is recommended if the rescuer is not trained (for example, in dispatcher assisted CPR) or is not willing to give rescue breaths. The aim is now to compress the chest to a depth of 5-6 cm (rather than 4-5 cm). This recommendation is based on several studies showing that deeper compressions were associated with improved short term outcomes. The risk of harm (such as …
Molecular monitoring in NUP214-ABL-positive T-acute lymphoblastic leukemia reveals clonal diversity and helps to guide targeted therapy
Authors: S Koschmieder, T Burmeister, M Brüggemann, A Berkemeier, S Volpert, P Wieacker, G Silling, N Gökbuget, C Müller-Tidow, W E Berdel, M Stelljes
Journal: Leukemia (2013)
HEMODYNAMIC IMPROVEMENT FOLLOWING LEVOSIMENDAN TREATMENT IN ACUTE MYOCARDIAL INFARCTION COMPLICATED BY CARDIOGENIC SHOCK PATIENTS TREATED WITH PRIMARY PCI AND IABP
Authors: Massimo Mancone, Mauro Pennacchi, Luigi Lucisano, Simone Calcagno, Alessandra D'Ambrosi, Azzurra Marceca, Noemi Bruno, Bruno Brasolin, Gennaro Sardella, Francesco Fedele
Journal: Journal of the American College of Cardiology (2013)
Bioethics after the Terror
Authors: Jonathan D. Moreno
Journal: The American Journal of Bioethics (2002)

Bioethics as a field has been fortunate that its values and concerns have mirrored the values and concerns of society. In light of the September 11th attacks, it is possible that we are witnessing the beginning of a transition in American culture, one fraught with implications for bioethics. The emphasis on autonomy and individual rights may come to be tempered by greater concern over the collective good. Increased emphasis on solidarity over autonomy could greatly alter public response to research abuses aimed at defense from bioterrorism, to privacy of genetic information, and to control of private medical resources to protect the public health.
THE SURGICAL TREATMENT OF SPASTIC PARALYSIS BY SYMPATHETIC RAMISECTION
Authors: N. D. Royle
Journal: JAMA (1926)

<h3>To the Editor:</h3> —InThe Journal, June 19 and 26, the relationship of the sympathetic nervous system to the surgery of spastic paralysis as advocated by myself is discussed. There are a few comments I should like to add to the discussion. In the first case, Dr. Steindler struck the right note when he suggested that the investigation should be investigated. Let me deal first of all with the statements of Drs. Forbes and Cobb. They are evidently unfamiliar with my original paper, or they would not make the statement that Hunter's theory and experiments preceded the operative treatment. As a matter of fact, with my first paper (A New Operative Procedure in the Treatment of Spastic Paralysis and Its Experimental Basis,<i>M. J. Australia</i><b>1</b>:77 [Jan. 26] 1924) John I. Hunter (The Postural Influence of the Sympathetic Innervation of Voluntary Muscle,<i>M. J. Australia</i><b>1</b>:86 [Jan. 26]
Physician Burnout: An Urgent Call for Early Intervention—Reply
Authors: Tait D. Shanafelt, Lotte N. Dyrbye, Colin P. West
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Acute non-infectious arthritis of the hip in patients with rheumatoid arthritis.
Authors: J T Halla, J G Hardin
Journal: Annals of the Rheumatic Diseases (1987)

Five patients with rheumatoid arthritis and no previous hip joint disease developed an acute disabling arthritis in one hip joint. Roentgenograms were negative and synovial fluid from the hip joint was inflammatory, but no crystals were seen and cultures were negative. Four of the five patients responded rapidly to intra-articular corticosteroids, and none of the five has had further hip joint symptoms during a mean follow up period of two years.
Corticosteroid Therapy for Severe Sepsis and Septic Shock
Authors: Peter C. Minneci
Journal: JAMA (2009)

To the Editor: The systematic review by Dr Annane and colleagues summarized the results of 22 clinical trials investigating corticosteroid therapy in sepsis. The review suggested that prolonged low-dose corticosteroid therapy ( 5 days, 300 mg/d of hydrocortisone or equivalent) decreases mortality and recommended treating adult patients with vasopressor-dependent septic shock. However, we believe that these recommendations are weakened by possible publication bias and by the relationship between severity of illness and the treatment effect of corticosteroids. The review stated that “the funnel plot did not suggest evidence for publication bias.” However, in a recent systematic review of corticosteroids in sepsis, we demonstrated publication bias within the group of trials investigating prolonged low-dose corticosteroids using an Egger regression test and a funnel plot. Therefore, we recommend performing similar analyses to examine the 12 trials investigating prolonged low-dose corticosteroids included in this review. Findings consistent with publication bias would imply that the overall reported improvement in mortality may be due to inclusion of a disproportionately high number of small trials demonstrating beneficial effects of corticosteroids. Small negative trials may be unavailable for inclusion because they were either not reported or not accepted for publication. Potential publication bias is concerning because the CORTICUS trial, accounting for more than 40% of patients in this subgroup analysis, demonstrated no benefit of low-dose corticosteroids in patients with vasopressor-dependent septic shock. The review also suggested an interaction between mortality in the control group and the effects of corticosteroid therapy (P=.06). We recommend examining the data (excluding the Schumer trial for consistency with the other analyses) for a relationship between severity of illness (measured by control group mortality) and treatment effect, using fixed-effects or unrestricted maximum likelihood models. If significant, this would suggest that low-dose corticosteroids decrease mortality only in more severely ill patient populations and would be consistent with our findings and with reported effects of other anti-inflammatory agents in sepsis. Furthermore, such a relationship might in part explain the lack of benefit in the CORTICUS trial, which had a relatively low control mortality (31%) compared with the other the trials (median [interquartile range], 44% [25%-61%]). Long-course low-dose corticosteroids may improve survival only in severely ill patients with refractory vasopressordependent septic shock. Until further data become available, we believe that decisions to treat severely ill septic patients with corticosteroids should be based on individual patient risk-benefit assessments.