tbuckley/cabot-search huggingface dataset:
Maraviroc-induced decrease in circulating bacterial products is not linked to an increase in immune activation in HIV-infected individuals
Authors: Christina Psomas, Jean-Philippe Lavigne, Claudine Barbuat, Selma Trabelsi, Jade Ghosn, Caroline Lascoux-Combe, Philippe Flandre, Lise Cuzin, Jacques Reynes, Brigitte Autran, Pierre Corbeau
Journal: Blood (2013)
Updates for US heart disease death rates
Authors: S. Gottlieb
Journal: BMJ (1999)

The number of deaths from heart disease has been increasing in the United States as the percentage of individuals over the age of 65has risen, according to new figures that take into account the ageing population.

Latest figures from the American Heart Association have shown that a fifth of the US population (58.8million Americans) currently has cardiovascular disease. The association said that its most recent projections-reflecting new statistical formulas designed to adjust …
BMA explains its reservations on Griffiths
Authors: W. Russell
Journal: BMJ (1984)

In politics, as in so many other of life's activities, it is as well not to count one's chickens before the eggs are hatched.That was in no doubt on the day that Mr Anthony Grabham, chairman of the BMA council, and Dr John Havard, secretary of the BMA, left feeling satisfied with the evidence that they had given to the Commons social services select committee on the Griffiths report.They certainly put across the medical profession's doubts about the new management structure-the report's central recommendationmost effectively.But sitting back listening to both sides of the argument-something that witnesses do not have the leisure to do-it seemed to me that the committee's report could be less sympathetic when it appears later next month than the BMA hopes.Mrs Renee Short, Labour MP for Wolverhampton North East, who chairs the all party committee, was friendly enough, but Labour's attitude to Griffiths is not all that enthusiastic.It was Mr David Crouch, Conservative MP for Canterbury, who sounded the warning note, suggesting as "a little naive" Dr Havard's argument that the kind of management used in trade and commerce was not necessarily suitable for the National Health Service, where it was the team concept that mattered.
Hermes? Apollo? Ningishzida? Dracunculus?... Dracunculus??
Authors: Ronald Michael
Journal: JAMA (1989)

To the Editor.—  The controversy that rages inThe Journalover one snake or two 1 is a simple matter to settle. Do we as physicians wish to be represented by the staff of Asklēpios, for whatever aesthetic or nostalgic reasons, or do we wish to be associated with the oldest symbol of the healing profession? Serpents, to be sure, have been linked to fertility cults for many millennia. 2,3 With these we need not concern ourselves. Our task is to identify the first serpent-and-staff motif unequivocally associated with healing and accept it as our emblem.  History takes us back to Sumer, cultural predecessor of Assyria and Babylonia. Here, for the first time, we find on a libation vase to the god Ningishzida a deity represented by two serpents entwined around a staff. 4 This deity, the personal god of Gudea, ruler of Lagash in southern Mesopotamia around 2150 BC,
Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide
Authors: Spyridon Mourtas, Mara Canovi, Cristiano Zona, Dario Aurilia, Anna Niarakis, Barbara La Ferla, Mario Salmona, Francesco Nicotra, Marco Gobbi, Sophia G. Antimisiaris
Journal: Biomaterials (2010)
Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function
Authors: Johannie Du Plessis, Hanne Vanheel, Carl E.I. Janssen, Leonie Roos, Tomas Slavik, Paraskevi I. Stivaktas, Martin Nieuwoudt, Stefan G. van Wyk, Warren Vieira, Etheresia Pretorius, Mervyn Beukes, Ricard Farré, Jan Tack, Wim Laleman, Johan Fevery, Frederik Nevens, Tania Roskams, Schalk W. Van der Merwe
Journal: Journal of Hepatology (2013)
Antibody studies claim awards spotlight
Authors: Phil Gunby
Journal: JAMA (1984)

Five men—two of whom are physicians—received Albert Lasker Medical Research Awards this week. Two of the five recipients also will receive this year's Nobel Prize in Medicine and Physiology. The two Lasker Award recipients who also will become Nobel laureates are: Georges J. F. Köhler, PhD, 38, a native of West Germany who has been on the staff of the Basel (Switzerland) Institute for Immunology since 1976. He becomes one of three directors of the Max Planck Institute for Immune Biology, Freiburg, West Germany, later this year. He received his doctorate in biology from the University of Freiburg in 1974, then spent two years at the Laboratory of Molecular Biology, Cambridge, England, with César Milstein, PhD (see below), where—according to the Lasker Award citation—the two researchers developed "the first hybridoma and monoclonal antibody technology." César Milstein, PhD, 57, was born in Argentina, received his doctorate from Cambridge University in 1960,
765 TYPE-I CALCIMIMETIC COMPOUNDS EXERT PORTAL HYPOTENSIVE EFFECTS IN RATS WITH CCL4-INDUCED ASCITIC LIVER CIRRHOSIS: A NEW THERAPEUTIC OPTION?
Authors: G. Sansoe', M. Aragno, C. Tomasinelli, F. Rosina, A. Smedile, F. Wong, M. Parola
Journal: Journal of Hepatology (2009)
Regional blood flow in internal carotid distribution during migraine attack.
Authors: E. Skinhoj, O. B. Paulson
Journal: BMJ (1969)

Diabetic Retinopathy-Soler et al.MEDICALJOURNAL 569counterparts.may have had asymptomatic diabetes of long duration.It is well known but not sufficiently recognized that the onset of diabetes often precedes the diagnosis by years rather than weeks or months, and it is wrong to suppose that the onset of symptoms, however acute, indicates the date when the disease first appeared.Our findings suggest that this may be true even in young patients.
Joslin's Diabetes Mellitus
Authors: G. Stephen DeCherney
Journal: JAMA (1994)

In the 13th largest hospital system in the United States (the Medical Center of Delaware), 12% of patients (excluding mothers and neonates) have diabetes mellitus. Whereas there are approximately 700 patients with diagnosed acquired immunodeficiency syndrome in Delaware, there are 20000 patients diagnosed with diabetes. The office of the primary care physician is filled with obese, hypertensive, older patients with diabetes mellitus. Arguably, diabetes mellitus and syndrome X are the leading pathophysiologic causes of death in the United States. The care of these patients is long-term, and it is easy to become inured. After a while, both the patient and the clinician lower their expectations of good glucose control. The onset of complications is insidious. Patients change doctors frequently, so the results of years of hyperglycemia become someone else's problem. In the face of the enormity of the problem, the 13th edition of<i>Joslin's Diabetes Mellitus</i>arrives in the office
Prospective analysis of possible myocardial damage or hemolysis occurring as a result of prolonged autoperfusion angioplasty in humans
Authors: Joseph B. Muhlestein, Peter J. Quigley, Erik Magnus Ohman, Robert P. Bauman, Michael H. Sketch, James E. Tcheng, Charles J. Davidson, Robert H. Peter, Victor S. Behar, Mitchell W. Krucoff, Yihong Kong, Harry R. Phillips
Journal: Journal of the American College of Cardiology (1992)
Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria
Authors: Gabriele Di Lorenzo, Maria Luisa Pacor, Pasquale Mansueto, Maria Esposito Pellitteri, Claudia Lo Bianco, Vito Ditta, Nicola Martinelli, Giovam Battista Rini
Journal: Journal of Allergy and Clinical Immunology (2004)
Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats.
Authors: J M Boylan, D L Brautigan, J Madden, T Raven, L Ellis, P A Gruppuso
Journal: Journal of Clinical Investigation (1992)

The involvement of tyrosine phosphorylation in insulin action led us to hypothesize that increased activity of protein tyrosine phosphatases (PTPases) might contribute to insulin resistance in alloxan diabetes in the rat. Hepatic PTPase activity was measured using two artificial substrates phosphorylated on tyrosine: reduced, carboxyamidomethylated, and maleylated lysozyme (P-Tyr-RCML) and myelin basic protein (P-Tyr-MBP), as well as an autophosphorylated 48-kD insulin receptor tyrosine kinase domain (P-Tyr-IRKD). Rats that were made alloxan diabetic exhibited a significant increase in hepatic membrane (detergent-soluble) PTPase activity measured with P-Tyr-MBP, without a change in activity measured with P-Tyr-RCML or the P-Tyr-IRKD. The PTPase active with P-Tyr-MBP behaved as a high molecular weight peak during gel filtration chromatography. Characterization of this enzyme indicated it shared properties with CD45, the prototype for a class of transmembrane, receptor-like PTPases. Our results indicate that alloxan diabetes in the rat is associated with an increase in the activity of a large, membrane-associated PTPase which accounts for only a small proportion of insulin receptor tyrosine dephosphorylation. Nonetheless, increased activity of this PTPase may oppose tyrosine kinase-mediated insulin signal transmission, thus contributing to insulin resistance.
Circulatory Dynamics in the Presence of Carotid-Jugular Fistula
Authors: THOMAS W. HOLMES
Journal: Circulation (1964)

Two patients are presented, in whom right common carotid artery-internal jugular vein fistula had been patent for 12 years. These cases provide the longest reported follow-up of patients with surgically created carotid-jugular fistulas. Marked cardiac hypertrophy, a systolic murmur in one patient, and arterial hypertension in the other, proved reversible following repair of the fistulas. Alterations in circulatory dynamics before and after repair are correlated with established phenomena associated with arteriovenous fistulas of various size, duration, and anatomic location.
A Case of Pelvic Tumour Treated by Galvano-Puncture: Cured
Authors: J. Inglis-Parsons
Journal: BMJ (1889)

those connected with intra-ocular tumours and with intra-ocular heemorrhage, II5± 14i1f293'WZ.)#., QiFIL VLtJUUV ¶3 }
Survival with bladder cancer, evaluation of delay in treatment, type of surgeon, and modality of treatment.
Authors: M C Gulliford, A Petruckevitch, P G Burney
Journal: BMJ (1991)

OBJECTIVE--To determine whether length of delay before treatment; specialty and grade of the surgeon; and use made of surgery, radiotherapy, and chemotherapy influenced the survival of patients with cancer of the bladder, after adjusting for case severity. DESIGN--Retrospective cohort study. SETTING--South East and South West Thames health regions. PATIENTS--609 men aged under 75 resident in the South Thames regions who had been registered as new cases of bladder cancer in 1982, 35 of whom were excluded, leaving 574 eligible patients. Analysis was based on 75% retrieval rate for case notes. MAIN OUTCOME MEASURES--Duration of survival from date of diagnosis of the bladder tumour. RESULTS--10 prognostic variables were used to adjust for case severity. The median delay from referral to first treatment was 48 (interquartile range 27-84) days. Treatment after a short delay was associated with shorter survival because of the early treatment of more severe cases. Consultants treated 68% of patients, trainee surgeons treated less severe cases. Initial treatment was by a urologist in 67% of cases, but the specialty of the surgeon was not associated with prognosis. The associations of radiotherapy, cystectomy, and systemic chemotherapy with survival were interpreted in terms of selection bias as well as therapeutic effect. CONCLUSION--Case severity was the most important influence on survival and influenced length of delay before treatment, grade and specialty of the surgeon, and main treatment allocation. After adjusting for case severity variations in these processes of care were not strongly associated with variations in survival.
Effects of drinking water monochloramine on lipid and thyroid metabolism in healthy men.
Authors: R G Wones, C C Deck, B Stadler, S Roark, E Hogg, L A Frohman
Journal: Environmental Health Perspectives (1993)

The purpose of this study was to determine whether a 4-week consumption of 1.5L per day of drinking water containing monochloramine at a concentration of 2 ppm (ppm = mg/L) or 15 ppm under controlled conditions would alter parameters of lipid or thyroid metabolism in healthy men. Forty-eight men completed an 8-week protocol during which diet (600 mg cholesterol per day, 40% calories as fat) and other factors known to affect lipid metabolism were controlled. During the first 4 weeks of the protocol, all subjects consumed distilled water. During the second 4 weeks, one-third of the subjects were assigned randomly to drink 1.5 L per day of water containing 2 ppm of monochloramine, to drink 1.5 L per day of water containing 15 ppm monochloramine, or to continue drinking distilled water. Four blood samples were collected from each subject at the end of each 4-week study period. Subjects drinking monochloramine at a concentration of 2 ppm showed no significant changes in total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoproteins A1, A2, or B when compared to the distilled water group. Parameters of thyroid function also were unchanged by exposure to monochloramine at this concentration. However, subjects drinking monochloramine at a concentration of 15 ppm experienced an increase in the level of apolipoprotein B. Other parameters of lipid and thyroid metabolism did not change. We conclude that consumption of drinking water containing 2 ppm of monochloramine does not alter parameters of lipid and thyroid metabolism in healthy men. Consumption of water containing 15 ppm monochloramine may be associated with increased levels of plasma apolipoprotein B.
40 DEPLETION OF CASPASE-8 PROTECTS FROM FAS- AND LPS-MEDIATED LIVER INJURY BUT NOT FROM CONCANAVALIN A INDUCED HEPATITIS IN MICE
Authors: C. Liedtke, J. Freimuth, K.L. Streetz, N. Beraza, D. Lambertz, N. Gassler, D. Riethmacher, C. Trautwein
Journal: Journal of Hepatology (2008)
Hydrogen peroxide-responsive copolyoxalate nanoparticles for detection and therapy of ischemia–reperfusion injury
Authors: Dongwon Lee, Soochan Bae, Qingen Ke, Jiyoo Lee, Byungjoo Song, S. Ananth Karumanchi, Gilson Khang, Hak Soo Choi, Peter M. Kang
Journal: Journal of Controlled Release (2013)
Additional Data Favoring Use of Anticoagulant Therapy in Myocardial Infarction
Authors: Moyses Szklo, James A. Tonascia, Robert Goldberg, Harold L. Kennedy
Journal: JAMA (1979)

A community-wide study was conducted in metropolitan Baltimore in which the survival of 1,307 patients with acute myocardial infarction was examined according to use of anticoagulants. The adjusted in-hospital case-fatality rate was lower for patients receiving anticoagulants (18%) than for those not receiving this therapy (31%). This difference persisted in each period examined in the study (1966 and 1967 or 1971) and was found in 17 of 20 participating hospitals. For hospital survivors followed up for as long as ten years, a better survival was again found for those treated with anticoagulants in the acute phase compared with those not treated. (<i>JAMA</i>242:1261-1264, 1979)
Clinical Inertia as a Clinical Safeguard
Authors: Dario Giugliano
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EFFECTS OF A DIRECT RENNIN INHIBITOR OR A DIURETIC ADDED ON AN ANGIOTENSIN II RECEPTOR BLOCKER ON CENTRAL AORTIC PRESSURE IN HYPERTENSIVE PATIENTS (ALEA STUDY)
Authors: Toru Miyoshi, Tadahisa Uesugi, Satoru Sakuragi, Takefumi Oka, Masayuki Doi, Seiji Nanba, Motoki Kubo, Masashi Yoshida, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito
Journal: Journal of the American College of Cardiology (2014)
Origin of Seizures in Elderly Patients
Authors: Clifford Schold
Journal: JAMA (1977)

Among 50 previously well patients, aged 69 years or older, who had a first seizure, a cause could be identified in only 25 (50%). Cerebrovascular disease accounted for the seizures in 30% of the total group. Only one tumor was found. Treatable causes were found in 20%. In 25 patients (50%), a cause could not be identified. A total of 56% of the patients had focal motor seizures, and in 44%, the seizures were generalized. A definite cause could be established in 57% of those with focal seizure and in 41% of those with generalized seizures. These results are compared with previous surveys of adult-onset epilepsy and indicate a somewhat different etiologic distribution in elderly patients.
Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in rheumatoid arthritis
Authors: F Brentano, C Ospelt, J Stanczyk, R E Gay, S Gay, D Kyburz
Journal: Annals of the Rheumatic Diseases (2008)

Objective: Interleukin (IL)23, composed of a p19 and a p40 subunit, is suggested to play key roles in rheumatoid arthritis (RA), dependent on the promotion and proliferation of IL17-producing T helper (Th)17 cells. However, previous studies on IL23 expression in human tissues were based on the p19 subunit only. We aimed to study the expression and regulation of IL23 subunits p19 and p40 in RA compared to patients with osteoarthritis (OA). Methods: The expression of p19 and p40 in synovial tissues was analysed by in situ hybridisation and immunohistochemistry. IL23 in RA and OA synovial fluids and sera was determined by ELISA. Toll-like receptor (TLR)-dependent induction of p19, p40 and bioactive IL23 was determined in RA synovial fibroblasts (RASF), monocytes and monocyte-derived dendritic cells (MDDCs) by real-time PCR and reverse transcriptase (RT)-PCR, Western blot and functional assays. Results: The p19 subunit was abundantly expressed in RA but not in OA synovial tissues. p19 was most prominently expressed by RASF in the synovial lining layer and at the site of invasion, but no heterodimeric IL23 was detected at these sites. Correspondingly, soluble IL23 was not detectable or found at very low levels in synovial fluids and sera of patients with RA. By in vitro experiments, we confirmed that TLR-activated RASF expressed p19 but not p40, in contrast to monocytes, which produced IL23 following TLR stimulation. Conclusion: The TLR-dependent induction of p19 but not p40 in RASF and the abundant expression of p19 along with the low or undetectable levels of IL23 in patients with RA provides strong evidence that p19 does not necessarily indicate the presence of IL23, as has been proposed to date.
Pharmacokinetics of Gefitinib Predicts Antitumor Activity for Advanced Non-small Cell Lung Cancer
Authors: Yoichi Nakamura, Kazumi Sano, Hiroshi Soda, Hiroshi Takatani, Minoru Fukuda, Seiji Nagashima, Tomayoshi Hayashi, Mikio Oka, Kazuhiro Tsukamoto, Shigeru Kohno
Journal: Journal of Thoracic Oncology (2010)
Abstract 4552: Does 'Late Catch-Up' Exist in Drug Eluting Stents? Insights From a Serial Quantitative Coronary Angiography Analysis
Authors: Kyung Woo Park, Chi-hoon Kim, Il-Young Oh, Seung-Jung Park, Chang-Hwan Yoon, Woo-hyun Lim, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Byung Hee Oh, Young-Bae Park, Hyo-Soo Kim
Journal: Circulation (2009)
The Suicide Gene Therapy Challenge: How to Improve a Successful Gene Therapy Approach
Authors: Chiara Bonini, Attilio Bondanza, Serena Kimi Perna, Shin Kaneko, Catia Traversari, Fabio Ciceri, Claudio Bordignon
Journal: Molecular Therapy (2007)

The transfer of a suicide gene into donor lymphocytes to control alloreactivity in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the widest clinical application of T-cell based gene transfer, as shown by more than 100 patients treated worldwide to date, several phase I–II studies completed, and a registrative phase III study, sponsored by a biotech firm, about to begin. In this mini-review, we will summarize the clinical results obtained to date, and attempt to identify the steps envisaged to optimize the suicide gene therapy approach. The transfer of a suicide gene into donor lymphocytes to control alloreactivity in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the widest clinical application of T-cell based gene transfer, as shown by more than 100 patients treated worldwide to date, several phase I–II studies completed, and a registrative phase III study, sponsored by a biotech firm, about to begin. In this mini-review, we will summarize the clinical results obtained to date, and attempt to identify the steps envisaged to optimize the suicide gene therapy approach.
QOF and whistleblowers
Authors: J. Smith
Journal: BMJ (2009)

This week Chris Ham (doi:10.1136/bmj.b2198) contrasts the UK Conservative party’s reliance on markets to improve performance with the “targets and terror” approach that has driven many of the recent improvements in the NHS. Many readers will like that description—though you probably also share Ham’s (familiar) concerns about the effectiveness of markets for health care.

Yet not all targets have been accompanied by terror: some have hefty incentives. None more so than the Quality and Outcomes Framework (QOF) in general practice, one of the most ambitious “pay for performance” systems in the world ( BMJ 2003;326:457, doi:10.1136/bmj.326.7387.457). So far the verdict has …