tbuckley/cabot-search huggingface dataset:
Patients With Depressive Symptoms Have Lower Health Status Benefits After Coronary Artery Bypass Surgery
Authors: Susmita Mallik, Harlan M. Krumholz, Zhen Qiu Lin, Stanislav V. Kasl, Jennifer A. Mattera, Sarah A. Roumains, Viola Vaccarino
Journal: Circulation (2005)

Background— Depression is an established independent prognostic factor for mortality, readmission, and cardiac events after CABG surgery. However, limited data exist on whether depression influences functional outcomes after CABG. Methods and Results— We followed 963 patients who underwent first CABG between February 1999 and February 2001. At baseline and at 6 months after CABG, we interviewed patients to assess depressive symptoms using the Geriatric Depression Scale (GDS) and physical function using the Short Form-36 Physical Component Scale (PCS). The patient’s physical function was considered improved if the PCS score increased ≥5 points at 6 months. Patients with high GDS scores were younger, were more often female, and had worse physical function and higher comorbidity than patients with low GDS scores. Rates of improvement in physical function were 60.1% for a GDS score &lt;5 (below 75th percentile), 49.8% for a GDS score between 5 and 9 (75th to 90th percentile), and 39.7% for a GDS score ≥10 (≥90th percentile; P =0.002 for the trend). Depressive symptoms remained a significant independent predictor of lack of functional improvement after adjustment for severity of coronary artery disease, angina class, baseline PCS score, and medical history. A GDS score ≥10 was a stronger inverse risk factor for functional improvement after CABG than such traditional measures of disease severity as previous myocardial infarction, heart failure on admission, history of diabetes, and left ventricular ejection fraction. Conclusions— Higher levels of depressive symptoms at the time of CABG are a strong risk factor for lack of functional benefits 6 months after CABG.
Licensure or Responsible Delegation?
Authors: Martha D. Ballenger, E. Harvey Estes
Journal: New England Journal of Medicine (1971)

The rapid emergence of a variety of new types of physician support personnel, well exemplified in Lohrenz's article in this issue, has raised a number of questions regarding methods of regulation and control of these new professions for the protection of both the patient and the health professions.Licensure, the method whereby formal permission is granted by a constituted (usually governmental) authority to carry on a specified activity, is the traditional method of regulation in the health field and is familiar to physicians and most other health professionals. It is not surprising that separate licenses for each new health profession . . .
How could I have done that?
Authors: P. D Snashall
Journal: BMJ (2009)

In mid-1968 I was a preregistration house officer, and the United Kingdom was fearing a flu pandemic. Hong Kong flu (H3N2) had appeared at the start of the year and was ravaging South East Asia. It was predicted to reach UK shores at the end of the year. Matters moved slower then than now.

In September my 2 year old daughter developed a persistent cough. Her GP grandfather was worried about pertussis, so I swabbed her throat for analysis. About a week later, my friend in …
Comparison of continuous and intermittent factor VIII concentrate therapy in hemophilia A
Authors: W. E. Hathaway, M. J. Christian, S. L. Clarke, U. Hasiba
Journal: American Journal of Hematology (1984)

Comparison of continuous versus intermittent (every 12 h bolus) infusion of a high-purity Factor VIII concentrate in 12 severe hemophilia A patients undergoing surgical procedures indicated that a higher (50 u/dl versus 35 u/dl) minimal plasma level was seen with the same amount of product when given continuously. A continuous VIII concentrate infusion of 2 u/kg/h produces a mean VIIIc level of about 50 u/dl or, alternatively, about 0.04 u/kg/h raises the VIIIc level by 1 u/dl (1%). None of the patients showed any abnormal bleeding. Higher plasma levels of VIIIc were noted by the two-stage VIIIc assay than by the one-stage VIIIc assay. Fibrinogen levels were normal or only slightly elevated, and the monomer test was consistently negative.
Epidemiology in Country Practice
Authors: John Pemberton
Journal: New England Journal of Medicine (1955)

DR. William Pickles, a general practitioner of Yorkshire, England, was the lecturer at a meeting on July 20 at the Harvard Club, Boston, organized by the Massachusetts Academy of General Practice. Dr. Pickles is no newcomer to Boston, having delivered the Cutter Lecture at the Harvard School of Public Health in 1948. Since that occasion he has lectured in Australia and Africa and has been elected the first president of the recently formed British College of General Practice.On this occasion he spoke of the unique opportunities of the family doctor who practices in a sparsely populated rural area to . . .
Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3
Authors: Tessa L. Holyoake, Xiaoyan Jiang, Heather G. Jorgensen, Susan Graham, Michael J. Alcorn, Chris Laird, Allen C. Eaves, Connie J. Eaves
Journal: Blood (2001)
Should we pay the patient? Review of financial incentives to enhance patient compliance
Authors: Antonio Giuffrida, David J Torgerson
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To determine whether financial incentives increase patients9 compliance with healthcare treatments. <b>Data sources:</b> Systematic literature review of computer databases—Medline, Embase, PsychLit, EconLit, and the Cochrane Database of Clinical Trials. In addition, the reference list of each retrieved article was reviewed and relevant citations retrieved. <b>Study selection:</b> Only randomised trials with quantitative data concerning the effect of financial incentives (cash, vouchers, lottery tickets, or gifts) on compliance with medication, medical advice, or medical appointments were included in the review. Eleven papers were identified as meeting the selection criteria. <b>Data extraction:</b> Data on study populations, interventions, and outcomes were extracted and analysed using odds ratios and the number of patients needed to be treated to improve compliance by one patient. <b>Results:</b> 10 of the 11 studies showed improvements in patient compliance with the use of financial incentives. <b>Conclusions:</b> Financial incentives can improve patient compliance. <h3>Key messages</h3> Non-compliance with medical treatment is a widespread problem Non-compliance may lead to increased treatment costs in future Financial incentives can significantly reduce non-compliance Incentives can be cost effective, particularly for treatment of infectious disease Research in the context of the United Kingdom is required
Contact allergens, but not irritants, alter receptor-mediated endocytosis by human epidermal Langerhans cells
Authors: H. RIZOVA, P. CARAYON, A. BARBIER, F. LACHERETZ, L. DUBERTRET, L. MICHEL
Journal: British Journal of Dermatology (1999)

Allergic contact dermatitis is a T-cell-mediated inflammation, induced by contact with sensitizers and occurring through the release of epidermal cytokines and the activation of epidermal Langerhans cells (LCs). The aim of this study was to analyse early events of LC activation induced either by contact allergens or by irritants devoid of any contact allergenic properties. in order to obtain an in vitro method to discriminate between these two groups of molecules. Various contact sensitizers and irritants were studied for their effects on the endocytosis of major histocompatibility complex class II (MHC-II) molecules by freshly-isolated human epidermal LCs. As observed by flow cytometry, a spontaneous decrease in the surface expression of MHC-II (HLA-DR) molecules, linked to spontaneous internalization of the MHC-II molecules by LCs, was obtained by moving freshly-isolated LCs from 4 degrees C to 37 degrees C. Pre-incubation of LCs with either sensitizers or irritants increased the spontaneous internalization of HLA-DR molecules with a similar magnitude, but no clear discrimination between sensitizer and irritant effects was obtained by flow cytometry analysis. In contrast, confocal microscopy enabled discrimination between the effects of sensitizers and irritants: sensitizer-treated samples showed internalized HLA-DR molecules aggregated in large vesicles with very bright fluorescence; irritant-treated samples were not different from untreated controls and showed compact HLA-DR molecules in small vesicles with diffuse fluorescence, and mostly localized in the submembranous zone. Electron microscopy demonstrated that sensitizer-treated LCs internalized HLA-DR molecules preferentially in lysosomes collected near the nucleus, whereas the irritant-treated and non-treated LCs internalized these molecules in the prelysosomes only near the cell membrane. We conclude that contact allergens and irritants induce distinct patterns of HLA-I)R endocytosis, which may be useful for the development of in vitro screening tests.
A Randomized Trial of Adjuvant Chemotherapy with Uracil–Tegafur for Adenocarcinoma of the Lung
Authors: Harubumi Kato, Yukito Ichinose, Morio Ohta, Enjo Hata, Noriaki Tsubota, Hirohito Tada, Yoh Watanabe, Hiromi Wada, Masahiro Tsuboi, Nobuyuki Hamajima, Mitsuo Ohta
Journal: New England Journal of Medicine (2004)

In a previous phase 3 trial of adjuvant chemotherapy after resection of non–small-cell lung cancer, a combination of uracil and tegafur (often referred to as UFT) taken orally was shown to prolong survival. A subgroup analysis disclosed that most patients who benefited had pathological stage I adenocarcinoma.
FURTHER STUDIES ON THE DICK TEST
Authors: P. S. ROSEN
Journal: JAMA (1925)

We have made 2,487 Dick reactions on healthy persons among the inhabitants of the small manufacturing town Jarcewo, in the Smolensky district. The reaction was made with the toxin of the Metchnikoff Institute, purified after the Hentoon process. The strength of the toxin was 1:500. We have obtained 867 positive and combined reactions, or 34.9 per cent., a lower percentage than that obtained in Moscow. This difference may be explained by the fact that there was an epidemic of scarlet fever at Jarcewo. Out of twenty-nine old persons, most of whom were over 60, there was only one with a slight positive reaction. It is noteworthy that during the epidemic of scarlet fever in the Farröer islands at Tjornshown, there were ill with the disease only 2.9 per cent, of the inhabitants between the ages of 40 and 60 years, and only 1.8 per cent, of the persons over 60.
Beta endorphin: a factor in "fun run" collapse?
Authors: G Dale, J A Fleetwood, A Weddell, R D Ellis
Journal: BMJ (1987)

Au cours des 6 dernieres annees, 38 des participants de la course annuelle de Teyneside (demi-marathon, environ 25000 participants par an) ont presente un collapsus avant l'arrivee. Les concentrations plasmatiques de β endorphine sont elevees chez ces coureurs. Verification de l'augmentation des taux de β endorphine au cours d'epreuves d'effort
1149-156 Mitral deceleration time in acute myocardial infarction: Relation to myocardial perfusion after successful primary percutaneous coronary intervention
Authors: Giampaolo Cerisano, Angela Migliorini, Domenico Pucci, Piergiovanni Buonamici, Renato Valenti, Leonardo Bolognese, Guido Parodi, David Antoniucci
Journal: Journal of the American College of Cardiology (2004)
Interleukin-28B genetic variants and hepatitis virus infection by different viral genotypes
Authors: Marco Antonio Montes-Cano, José Raúl García-Lozano, Cristina Abad-Molina, Manuel Romero-Gómez, Natalia Barroso, José Aguilar-Reina, Antonio Núñez-Roldán, María Francisca González-Escribano
Journal: Hepatology (2010)

Genetic host factors may modify the course of the hepatitis C virus (HCV) infection. Very recently, a genome-wide scan that reported association of the IL28B locus with response to treatment in HCV infection was published. The aim of the current study was to investigate the relationship of this locus with outcome of HCV infection in a cohort constituted by a total of 731 Spanish individuals. From these, 284 were subjects with persistent infection, 69 were individuals who naturally cleared the virus, and 378 were noninfected subjects. Genotyping of the rs12979860 (C&gt;T) in the IL28B locus was performed using a TaqMan 5′ allelic discrimination assay. The CC genotype was overrepresented among patients infected with viral genotypes non-1 (66.7% versus 39.1% in patients infected with viral genotype-1, P = 8.5 × 10−5, odds ratio [OR] = 0.32, 95% confidence interval [CI] 0.17-0.60); patients with spontaneous resolution of infection (72.5% versus 45.6% of the individuals with persistent infection, P = 6.2 × 10−5, OR = 0.32; 95%CI, 0.18-0.57); and lastly, patients with sustained response (60.2% versus 32.1% found in patients with nonsustained response, P = 3.1 × 10−5, OR = 0.31; 95%CI, 0.17-0.56). Conclusion: We have found different rates of viral genotype infection depending on the IL28B variant as well as an association of this locus with natural and treatment-mediated response. Hepatology 2010
Over 55s in US are less healthy than their English peers but live longer
Authors: A. McGauran
Journal: BMJ (2010)

Older Americans are less healthy than their English peers but live as long or longer, depending on age group, fuelling the debate about the relative quality of healthcare in both countries.

The findings come from a new study by researchers from the Institute of Fiscal Studies in London and the non-profit US based think tank the Rand Corporation. It looked at stroke, lung disease, cancer, high blood pressure, diabetes, and heart disease. Americans in both the 55-64 and 70-80 year age groups had a higher prevalence of disease than their counterparts in England. The study found that in the younger age group each disease was more prevalent among Americans than among the English. But while Americans aged >64 also had a …
Penicillin Treatment of Neurosyphilis
Authors: Frank W. Yoder
Journal: JAMA (1975)

A 60-year-old man with symptomatic neurosyphilis was treated with penicillin G procaine in the dosages recommended by the Public Health Service, and a less than spirocheticidal level of penicillin G was found in the cerebrospinal fluid. (<i>JAMA</i>232:270-271, 1975)
One-View Follow-up Mammogram-Reply
Authors: Daniel S. Cukier
Journal: JAMA (1977)

One observer was assigned to the task of determining specificity. This was accomplished by interspersing normal and fibrocystic cases between cancer cases. His accuracy was 90%, although most cases missed were errors of interpretation rather than failure of informational content in the film. Cancer size varied from 3-mm area of microcalcifications to 6-cm neoplasms. Over 90% of cases were new; 10% had previous films for comparison.
Effects of Marihuana on Flying Ability
Authors: Martin P. Meacham
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Since being informed of a number of instances in which pilots have flown aircraft while "high" on marihuana, we have studied the effects of marihuana intoxication on the ability of certified pilots to operate a general aviation model ATC-510 instrument flight simulator. Three professional and three private pilots were recruited. All had a history of smoking marihuana for several years and could currently be described as infrequent marihuana users. The pilots were familiarized with a specific flight sequence that included maneuvers typically encountered in instrument flight (straight and level flight, turns, three-dimensional maneuvering, radio navigation). After the pilots attained proficiency in "flying" the simulator and in the specific flight sequence, standardized marihuana (6.3 mg of Δ<sup>9</sup>tetrahydrocannabinol) or a matched marihuana placebo (0.2 mg of Δ<sup>9</sup>tetrahydrocannabinol), supplied by the National Institute of Drug Abuse, was smoked over a 10-minute period in a pipe, utilizing
The C.S.F. in Acute Anterior Poliomyelitis
Authors: A. L. Eyre-Brook
Journal: BMJ (1942)

JOURNALproximal portion of the excretory apparatus.Even after 84 hours the kidneys cast an abnormally dense shadow, indicating that some of the dye was still being retained.Volhard's test was carried out on Sept. 19, with the following result: Specific gravity of urine during 24 hours with forced fluids: minimum reading 1000.Specific gravity of urine during 24 hours without fluids: maximum reading 1028.Discussion Prominent in the consideration of the treatment of this case was the assumption that the renal tubules were blocked with sulphapyridine crystals.With the aim of promoting active hyperaemia of the glomeruli and increasing secretion it was decided to employ inductotherm (short-wave) treatment.This method of heating deep tissues, the most efficient in use, has been applied previously in cases of renal disease (Stark, 1939), but we have been unable to find any reference to its employ- ment in anuria resulting from the use of the sulphonamide s.eries of drugs.The results in this case indicate that it may be of considerable value in the treatment of cases in which the condition is due primarily to mechanical obstruction of the renal tubules.lt is unlikely that this treatment would be equally effective when glomerular damage is present.It would appear that in cases with oliguria or anuria arising from the use of the sulphonamides this method of treatment is worthy of trial before submitting the patient to ureteric catheterization and lavage of the renal pelves, a procedure which may be inadvisable when an infection of the urinary tract is present.Catheterization will of course be required when the ureteric lumen is completely occluded.The x-ray findings in this case indicate the presence of intra- renal,changes, gradually diminishing during convalescence.It is therefore apparent that, even though ureteric catherization may have to be carried out, short-wave therapy may be a useful adjunct in clearing the renal tubules to the greatest extent at the earliest opportunity.We wish to express our thanks to
Whence Come Nosocomial Infections?
Authors: John E. McGowan
Journal: New England Journal of Medicine (1982)

More than a century ago, Semmelweis instituted a control measure (washing the hands before examining a patient) that decreased the occurrence of nosocomial infections after delivery in women.1 In doing so, he indirectly demonstrated a method of transmission of bacteria to hospitalized patients. Since then, a succession of investigators have described a variety of ways in which microorganisms can be transmitted to both hospital patients and employees.2 Early studies of this type showed that potential bacterial pathogens were present in or on virtually all objects sampled from the hospital environment. Such results raised the possibility that these objects might be . . .
The risk linked to ionizing radiation: an alternative epidemiologic approach.
Authors: C de Brouwer, R Lagasse
Journal: Environmental Health Perspectives (2001)

Radioprotection norms have been based on risk models that have evolved over time. These models show relationships between exposure and observed effects. There is a high level of uncertainty regarding lower doses. Recommendations have been based on the conservative hypothesis of a linear relationship without threshold value. This relationship is still debated, and the diverse observations do not allow any definitive conclusion. Available data are contradictory, and various interpretations can be made. Here we review an alternative approach for defining causation and reconciling apparently contradictory conclusions. This alternative epidemiologic approach is based on causal groups: Each component of a causal group is necessary but not sufficient for causality. Many groups may be involved in causality. Thus, ionizing radiation may be a component of one or several causal groups. This formalization reconciles heterogeneous observations but implies searching for the interactions between components, mostly between critical components of a causal profile, and, for instance, the reasons why specific human groups would not show any effect despite exposure, when an effect would be expected.
Des drogues magiques des Aztèques à la thérapie psycholytique
Authors: A. Fanchamps
Journal: Psychotherapy and Psychosomatics (1962)

Research Articles| February 10 2010 Des drogues magiques des Aztèques à la thérapie psycholytique Subject Area: Psychiatry and Psychology A. Fanchamps A. Fanchamps Service de recherches cliniques du Département médico-biologique de Sandoz S.A., Bale, Suisse (Directeur: Dr. A. Cerletti) Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1962) 10 (5): 372–384. https://doi.org/10.1159/000285646 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation A. Fanchamps; Des drogues magiques des Aztèques à la thérapie psycholytique. Acta Psychotherapeutica et Psychosomatica 1 May 1962; 10 (5): 372–384. https://doi.org/10.1159/000285646 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1962Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.