tbuckley/cabot-search huggingface dataset:
A brain network response to sham surgery
Authors: Mariya V. Cherkasova, A. Jon Stoessl
Journal: Journal of Clinical Investigation (2014)

Evaluation of potential therapies for neurological disease has been challenging due to beneficial responses in patients receiving the sham/placebo treatment. Placebo effects are especially prominent in Parkinson's disease (PD), which has become a useful model for studying the neurobiology of placebo responses. In this issue of the JCI, Ko and colleagues identify a neural circuit associated with the placebo response in a PD patient cohort. The observed placebo effect-associated pattern involved metabolic activity increases that corresponded with long-term motor improvements after sham surgery. Presurgery activity in this network was inversely related to sham response, suggesting that this network has potential for identifying sham responders and thus reducing placebo-related variance in surgical trials.
Pretty asks House of Lords for right to assisted suicide
Authors: C. Dyer
Journal: BMJ (2001)

A terminally ill woman with motor neurone disease who wants her husband to be allowed to help her to die took her case to the United Kingdom's highest court last week. Diane Pretty, aged 42, who has only months to live, appealed to the House of Lords after failing in the High Court and the Court of Appeal.

Her lawyers argue that the law banning assisted suicide, which denies …
US Global Health Initiative takes shape
Authors: B. Roehr
Journal: BMJ (2010)

US president Barack Obama’s global health initiative will produce more value for money than current government aid programmes, a senior government official has said.

Amie Batson, deputy assistant administrator for global health, USAID, was speaking at a forum organised by the US think tank the Kaiser Family Foundation in Washington and said the initiative was an effort to create programmes that are sustainable and have “more value for the money than the US government is investing in the field.”

The initiative is billed as more comprehensive than the …
The association between urinary sodium excretion and blood pressure in children.
Authors: R Cooper, I Soltero, K Liu, D Berkson, S Levinson, J Stamler
Journal: Circulation (1980)

This study explored the association between sodium excretion and blood pressure (BP). A new method was used to minimize the measurement error introduced by the large intrinsic variability of 24-hour sodium excretion. The ratio of intra- to interindividual variation was used to estimate the number of measurements needed to characterize the individual. When seven consecutive 24-hour samples were collected from 73 children, ages 11-14 years, a significant correlation between mean individual sodium excretion and BP was demonstrated. The independent relationship persisted when controlling for height, weight, pulse, age, sex and race (p = 0.045), but was eliminated by simultaneously considering mean creatinine excretion. Although the cross-sectional association described is quantitatively weak, a linear relationship between BP and sodium over the range consumed in this society could be important for prevention.
A case of subcutaneous sparganosis: therapeutic assessment by an indirect immunofluorescence antibody titration using sections of the worm body obtained from the patient
Authors: S. Kimura, M. Kashima, Y. Kawa, F. Nakamura, Y. Nawa, K. Takai, M. Mizoguchi
Journal: British Journal of Dermatology (2003)

Journal Article A case of subcutaneous sparganosis: therapeutic assessment by an indirect immunofluorescence antibody titration using sections of the worm body obtained from the patient Get access S. Kimura, S. Kimura Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar M. Kashima, M. Kashima Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar Y. Kawa, Y. Kawa Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar F. Nakamura, F. Nakamura Department of Parasitology, Miyazaki Medical College, Miyazaki, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Nawa, Y. Nawa Department of Parasitology, Miyazaki Medical College, Miyazaki, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Takai, K. Takai Immunology and Medical Zoology, St Marianna University School of Medicine, 2‐16‐1 Sugao, Miyamae‐ku, Kawasaki, Kanagawa 216‐8511, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Mizoguchi M. Mizoguchi Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 2, 1 February 2003, Pages 369–371, https://doi.org/10.1046/j.1365-2133.2003.05097_6.x Published: 01 February 2003
Management of breast cancer Refer women to multidisciplinary breast clinics
Authors: J R Yarnold, J M Bliss, M Brunt, H Earl, S Kaye, M Mason, J Mossman, T Perren, M Richards, S E Clamp, I H Kunkler, U Chetty, A Rodger, I Rothwell, L Morrison, M Richards, H Statham, J Green, F Murton
Journal: BMJ (1994)

The optimal retirement income strategy is not a set of decisions made only upon retirement but a set of choices made throughout the retiree’s lifetime. In this article, a dynamic model is introduced where the level of annuitization both upon and during retirement, as well as the amount withdrawn from the portfolio, changes based on the retiree’s situation. This model, which better reflects the actual conditions and choices available to a retiree, results in a significant reduction in the optimal levels of annuitization, especially immediate annuitization upon retirement, when compared to static models. The costs associated with delaying the annuity decision are relatively small as long as the retiree implements a dynamic withdrawal strategy and starts to incorporate annuities by the tenth year of retirement. Overall, this analysis suggests that there is a significant potential benefit to retirees who implement dynamic strategies. Additionally, these dynamic strategies can result in an increase in certainty-equivalent wealth that is equivalent to an annual increase in risk-adjusted performance (i.e., alpha) of over 1.0% during retirement. <b>TOPICS:</b>Retirement, fixed income and structured finance
Gemcitabine-associated CD8+ CD30+ pseudolymphoma.
Authors: G. Marucci, E. Sgarbanti, A. Maestri, C. Calandri, G. Collina
Journal: British Journal of Dermatology (2001)

We describe a 69-year-old man with a non-small cell carcinoma of the lung, stage III B, who developed bilateral multiple erythematous lesions in the abdominal-inguinal area following treatment with gemcitabine. Histologically, the lesion was characterized by a heavy lymphocytic infiltrate with large CD30+ cells. The lesion was highly suggestive of cutaneous involvement by malignant lymphoma, but complete regression was observed after cessation of gemcitabine. Although rarely reported, gemcitabine therapy can induce skin lesions. Pathologists should be aware of this possibility in order to avoid a misdiagnosis.
Chemical contaminants in human milk: an overview.
Authors: B R Sonawane
Journal: Environmental Health Perspectives (1995)

This review contains a succinct overview of the nature and extent of the problem of contamination of human milk with environmental and occupational chemicals, excluding drugs. Factors influencing the levels of contaminants in breast milk are discussed. Also, data on major chemicals of concern with potential health risk(s) to the general population and risk-benefit considerations are dealt with briefly. Based on the available data on the subject, research needs have been identified and policy recommendations are suggested.
[561] OXIDATIVE STRESS AND INSULIN RESISTANCE CONTRIBUTE TO STEATOSIS IN HCV GENOTYPE NON-3 INFECTED PATIENTS
Authors: M. Vidali, R. Zampino, G. Occhino, A. Ivaldi, B. Guerrera, R. Serino, E. Albano, G. Ruggiero, L.E. Adinolfi
Journal: Journal of Hepatology (2007)
CLINICAL AND SEROLOGICAL FEATURES OF HUMAN HERPESVIRUS-6 INFECTION IN THREE ADULTS
Authors: JamesC. Niederman, MarkH. Kaplan, Chun-Ren Liu, NathanielA. Brown
Journal: The Lancet (1988)

3 adult patients with serological evidence of human herpesvirus-6 (HHV-6) infection had mild, afebrile illnesses with nonspecific symptoms. In each case, the characteristic clinical feature was the presence of enlarged, bilateral, non-tender, anterior and posterior cervical nodes early in the illness which persisted for up to 3 months. HHV-6 IgG antibody reciprocal titres of 160 to 2560 were found during acute infection, and decreased to a titre of 10 in 1 patient 3 years later. IgM responses were detected at low reciprocal titres (10) in 2 patients and disappeared after several months.
Frozen Pre-embryos
Authors: Dirck W. Brown
Journal: JAMA (1990)

<h3>To the Editor.—</h3> We were very disturbed by the Board of Trustees report "Frozen Pre-Embryos,"<sup>1</sup>in that the report showed an almost complete disregard for the psychological impact on the child so conceived. Donating the frozen pre-embryos to other parties is like treating the end product (the child) as a commodity that can be bartered at will. In vitro fertilization of the ovum and the sperm of a couple who otherwise would be unable to produce an offspring is a marvelous technical achievement. However, if for any reason the couple is unable or unwilling to utilize their "child-to-be," we do not believe that the pre-embryo should be "put up for grabs" and offered to a third party who is anxious to have a child. We abhor the practice reported to occur in some countries of selling or giving away children, and we believe that this is exactly what would
Improved Exercise Tolerance and Quality of Life With Cardiac Rehabilitation of Older Patients After Myocardial Infarction
Authors: Niccolò Marchionni, Francesco Fattirolli, Stefano Fumagalli, Neil Oldridge, Francesco Del Lungo, Linda Morosi, Costanza Burgisser, Giulio Masotti
Journal: Circulation (2003)

Whether cardiac rehabilitation (CR) is effective in patients older than 75 years, who have been excluded from most trials, remains unclear. We enrolled patients 46 to 86 years old in a randomized trial and assessed the effects of 2 months of post-myocardial infarction (MI) CR on total work capacity (TWC, in kilograms per meter) and health-related quality of life (HRQL).Of 773 screened patients, 270 without cardiac failure, dementia, disability, or contraindications to exercise were randomized to outpatient, hospital-based CR (Hosp-CR), home-based CR (Home-CR), or no CR within 3 predefined age groups (middle-aged, 45 to 65 years; old, 66 to 75 years; and very old, >75 years) of 90 patients each. TWC and HRQL were determined with cycle ergometry and Sickness Impact Profile at baseline, after CR, and 6 and 12 months later. Within each age group, TWC improved with Hosp-CR and Home-CR and was unchanged with no CR. The improvement was similar in middle-aged and old persons but smaller, although still significant, in very old patients. TWC reverted toward baseline by 12 months with Hosp-CR but not with Home-CR. HRQL improved in middle-aged and old CR and control patients but only with CR in very old patients. Complications were similar across treatment and age groups. Costs were lower for Home-CR than for Hosp-CR.Post-MI Hosp-CR and Home-CR are similarly effective in the short term and improve TWC and HRQL in each age group. However, with lower costs and more prolonged positive effects, Home-CR may be the treatment of choice in low-risk older patients.
Termination of Supraventricular Tachycardia Complicating the Wolff-Parkinson-White Syndrome with External Countershock
Authors: SUZANNE B. KNOEBEL, HAROLD KING, CHARLES FISCH
Journal: Circulation (1963)

A case that demonstrates the feasibility of using external electric countershock for termination of paroxysmal supraventricular tachycardia complicating the Wolff-Parkin-son-White syndrome is presented. The occurrence of fusion complexes between impulses originating in the sinoatrial and atrioventricular nodes was observed.
Breast feeding and hypertrophic pyloric stenosis: population based case-control study
Authors: A. Pisacane, U. de Luca, L. Criscuolo, F. Vaccaro, A. Valiante, A. Inglese, G. Caracciolo, L. Pinto
Journal: BMJ (1996)

Fig 1-Mean changes in blood flow, diastolic diameter, and distensibility ofbrachial artery in 12 diabetic subjects and 12 controls during reactive hyperaemia, 1Oug glyceryl trinitrate, and 400 ,ug glyceryl trinitrate.Bars show 95% confidence intervals (9) mm Hg; blood flow 45 (28) v 49 (41) m/min; diastolic diameter 482 (0 60) v 4-47 (1P05) mm; distensibility 4-8 (1-4) v 5 9 (1-6) per kPa).During reactive hyperaemia, heart rate, blood pressure, and the increase in brachial artery blood flow (5548% 700-* Diabetic subjects O Controls 0 450 0 20 200 <0 C a,~~~~~~~T C"
EAU 2004 Guidelines on Assessment, Therapy and Follow-Up of Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction (BPH Guidelines)
Authors: Stephan Madersbacher, Gerasimos Alivizatos, Jorgen Nordling, Carlos Rioja Sanz, Mark Emberton, Jean J.M.C.H. de la Rosette
Journal: European Urology (2004)
Correction: Corynebacterium hemolyticum Causing Pharyngitis and Rash in Young Adults
Authors: Richard A. Miller, King K. Holmes
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 March 1987Correction: Corynebacterium hemolyticum Causing Pharyngitis and Rash in Young AdultsRICHARD A. MILLER, M.D., KING K. HOLMES, M.D., Ph.D.RICHARD A. MILLER, M.D.Search for more papers by this author, KING K. HOLMES, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-483_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In reading the text of our article in the December issue ( 1 ), we noted a factually incorrect statement that resulted from our inadvertent deletion of a short clause during the preparation of the manuscript. The error occurs in the last sentence of the last paragraph on page 871. The sentence should read: "There is ample precedent in the genus Corynebacterium and in other bacteria for the presence of bacteriophage-linked toxins (for example, diphtheria, tetanus, botulism), and it is conceivable that a similar mechanism is operative in C. hemolyticum." The sentence, as published, incorrectly attributes the...Reference1. MILLERBRANCATOHOLMES RFK. Corynebacterium hemolyticum as a cause of pharyngitis and scarlatiniform rash in young adults. Ann Intern Med. 1986;105:867-72. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harborview Medical Center Seattle, WA 98104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOn Juror Decision Making: An Empathic InquiryThe recognition and significance of Arcanobacterium haemolyticum 1 March 1987Volume 106, Issue 3Page: 483-483KeywordsBacteriaBotulismDiphtheriaPharyngitisRashesTetanusToxinsYoung adults ePublished: 1 December 2008 Issue Published: 1 March 1987 PDF downloadLoading ...
Abstract 5056: Signaling pathways critical for insulin receptor substrate (IRS)-mediated disruption of MCF-10A acini formation
Authors: Bonita Tak-Yee Chan, Isere Kuiatse, Adrian V. Lee
Journal: Cancer Research (2010)

Abstract Insulin receptor substrate (IRS)-1 and IRS-2 are important adaptor proteins in insulin-like growth factor-I receptor (IGF-IR) signaling. IRS-1 and IRS-2 are expressed during mammary gland development and also in human breast tumors. In order to study the role of IRS-1 and IRS-2 in breast tumorigenesis, we overexpressed both IRS proteins in immortalized, non-transformed human mammary epithelial MCF-10A cells. It has been shown that MCF-10A cells form uniform, empty-lumen acini in three dimensional (3D) culture. We previously showed that overexpression of either IRS-1 or IRS-2 in MCF-10A cells disrupted the acini in 3D culture and resulted in extensive proliferation and disrupted apical-basal polarity. In both IRS-1 and IRS-2 overexpressing MCF-10A cells, an increase in tyrosine phosphorylation and association with p85 of both IRS proteins indicated that IRS-mediated signaling was activated. siRNA knockdown of the overexpressed IRS proteins reversed the disruption of MCF-10A acini, confirming that this is indeed an IRS-related event. In order to identify the critical effectors in IRS-mediated disruption of MCF-10A polarity and growth, we used small molecule inhibitors to screen multiple kinase signaling pathways upstream and downstream of the IRS proteins. Inhibition of Rac or atypical PKC (aPKC) didn't affect MCF-10A cell acini formation, however it abolished the IRS-mediated disruption of MCF-10A acini formation. Consistent with this, knockdown of Rac and aPKC by siRNA suppressed IRS-mediated disruption in acini formation. Rac belongs to the family of GTPase that regulates cell motility. aPKC is a key component of the PAR polarity complex, and has previously been shown to be involved in IRS-signaling in adipocytes. While the signaling mechanism of Rac and aPKC in the IRSs-induced disruption of acini is still unknown, we found that another component in the PAR polarity complex Par3 may associate with IRS proteins and leads to dissociation of the polarity complex. Taken together, overexpression of IRS-1 and IRS-2 disrupts the MCF-10A acini in 3D culture in part through Rac and aPKC pathways. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5056.
Seduction by Citation
Authors: F.J. Ingelfinger
Journal: New England Journal of Medicine (1976)

The pages of any book, tract or article dealing with medicine are apt to be profusely sprinkled with numerical superscripts (or their equivalents) guiding the reader to a reference list. Not only does the liberal presence of such reference numbers impart an aura of scholarship, but their judicious placement after this or that assertion subtly suggests documented validity. But watch out — those little numbers may be no more than the trappings of credibility. The primary sources cited may be misquoted, inapplicable, unreliable and occasionally even imaginary.The havoc raised by misquotation is self-evident, but even a literally accurate attribution . . .
Anorectal Cancer and Homosexuality
Authors: P. Kondlapoodi
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The article by Daling and colleagues (1982;247:1988) regarding the positive correlation between homosexual behavior and the incidence of anal cancer will undoubtedly stimulate a search for the etiologic factors responsible. While the authors themselves suggest a few possible mechanisms, namely, the trauma that results from anal intercourse, anorectal herpes, anorectal warts, and other sexually transmitted diseases, they do not consider the recently gathered information on the cancer promoting and initiating ability of certain factors in human seminal plasma, particularly prostaglandins (PGs). Fischer et al<sup>1</sup>have shown that tumor promotion is enhanced by PG E<sub>2</sub>and PG F<sub>2</sub>and initiation is enhanced by PG E<sub>2</sub>, PG F<sub>2</sub>, and PG E<sub>1</sub>. All three types of PGs are present in high concentrations in human seminal plasma; indeed, semen contains more PGs than any other biologic tissue or fluid.<sup>2</sup>Ablin et al<sup>3</sup>have
Death rates higher in Wales
Authors: R. Dobson
Journal: BMJ (1999)

Death rates for a number of major diseases, accidents, and suicides are higher in Wales than in England, the chief medical officer for the principality, Dr Ruth Hall, has warned in her annual report.

The Welsh rates for lung and breast cancer, coronary heart disease, and strokes, as well as suicides and accidents, are all higher. Deaths from stroke among people aged under 65 are …
Intracellular pH regulation in ferret ventricular muscle. The role of Na-H exchange and the influence of metabolic substrates.
Authors: L A Blatter, J A McGuigan
Journal: Circulation Research (1991)

Aspects of pH regulation in ferret ventricular cells have been investigated by using pH- and sodium-selective microelectrodes in bicarbonate-free Tyrode's solution. An acid load was produced by the transient application of NH4Cl (10 or 20 mmol/l). A complete recovery from an acid load was still observed after multiple applications of NH4Cl, but amiloride (0.75 or 1 mmol/l), a blocker of the Na-H exchanger, increased the acidification and inhibited the recovery. Measurements of intracellular sodium concentration showed a transient decrease during the application of NH4Cl and a transient increase above control values during recovery from acidification. This increase was inhibited by amiloride. Intracellular sodium loading (strophanthidin [low calcium-low potassium Tyrode's solution]) did not initially cause an intracellular pH (pHi) change, but the acidification induced by amiloride under those circumstances was larger. Reducing extracellular sodium concentration from 155 to 5 or to 1.5 mmol/l caused an acidification. Changing extracellular pH (pHo) from 6.4 to 8.4 caused an average linear change in pHi in the same direction of 0.085 pHi units/pHo units. The mean intracellular buffering capacity measured with the NH4Cl method and with the proton extrusion mechanism blocked by amiloride was 36 +/- 15 mmol pH-1.l-1 (mean +/- SD), approximately half that of previous estimations. Changing the metabolic substrate from glucose to pyruvate in the superfusing solution caused an acidification of 0.21 pH units. This could be partially blocked by alpha-cyano-4-hydroxycinnamate, a finding consistent with a pyruvate-H+ cotransport and/or a pyruvate-OH- countertransport system being present in ventricular cells. The results of the present study show that ventricular cells can effectively buffer hydrogen ions and that an Na-H exchange system plays a major role in the regulation of pHi.
Malignant pleural mesothelioma: time for translational research
Authors: Alfredo Cesario, Patrizia Russo, Silvia Viaggi, Sonya Trombino, Andrea Imperatori, Stefano Margaritora, Lorenzo Dominioni, Luigi Festi, Venanzio Porziella, Pierluigi Granone
Journal: The Lancet Oncology (2004)
A case of Ebola virus infection.
Authors: R T Emond, B Evans, E T Bowen, G Lloyd
Journal: BMJ (1977)

In November 1976 an investigator at the Microbiological Research Establishment accidentally inoculated himself while processing material from patients in Africa who had been suffering from a haemorrhagic fever of unknown cause. He developed an illness closely resembling Marburg disease, and a virus was isolated from his blood that resembled Marburg virus but was distinct serologically. The course of the illness was mild and may have been modified by treatment with human interferon and convalescent serum. Convalescence was protracted; there was evidence of bone-marrow depression and virus was excreted in low titre for some weeks. Recovery was complete. Infection was contained by barrier-nursing techniques using a negative-pressure plastic isolator and infection did not spread to attendant staff or to the community.