Long-Term Therapy of Urinary Tract Infections
Authors: CALVIN M. KUNIN
Journal: Annals of Internal Medicine (1975)

Editorials1 August 1975Long-Term Therapy of Urinary Tract InfectionsCALVIN M. KUNIN, M.D.CALVIN M. KUNIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-273 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA general consensus about treatment of urinary tract infections has begun to emerge over the past 20 years. Clearly, the concepts established by Kass in 1955 (1) that define the principles of chemotherapy have stood the test of time. The most important factors affecting both the initial and long-term prognosis are the presence of underlying structural or neurologic lesions that interfere with the voiding mechanism. Included here are foreign bodies such as renal, bladder, or prostatic calculi and catheters.The urinary tract is almost ideally suited to respond to chemotherapy. Relatively high levels of drug may be concentrated in the...References1. KASS E: Chemotherapeutic and antibiotic drugs in management of the urinary tract. Am J Med 18:764-781, 1955 CrossrefMedlineGoogle Scholar2. O'GRADYCATTELL FW: Kinetics of urinary tract infections. II. The bladder. Br J Urol 38:156-162, 1966 CrossrefMedlineGoogle Scholar3. BAILEYROBERTSGOWER RAR: Prevention of urinary-tract infection with low dose nitrofurantoin. Lancet 2:1112-1114, 1971 CrossrefMedlineGoogle Scholar4. HARDINGRONALD GA: A controlled study of antimicrobial prophylaxis of recurrent urinary infection in women. N Engl J Med 291:597-601, 1974 CrossrefMedlineGoogle Scholar5. VOSTI K: Recurrent urinary tract infections, prevention by prophylactic antibiotics after sexual intercourse. JAMA 231:934-940, 1975 CrossrefMedlineGoogle Scholar6. STAMEYMEARESWINNINGHAM TED: Chronic bacterial prostatitis and the diffusion of drugs into prostatic fluid. J Urol 103:187-194, 1970 CrossrefMedlineGoogle Scholar7. FREEMANBROMERBRANCATO RLF: Prevention of recurrent bacteriuria with continuous chemotherapy. Ann Intern Med 69:655-672, 1968 LinkGoogle Scholar8. TURCKPETERSDORF MR: Optimal duration of treatment of chronic urinary tract infection. Ann Intern Med 69:837-839, 1968 LinkGoogle Scholar9. KASANENKAARSALOHILTUNEN AER: Comparison of long term, low dosage nitrofurantoin, methenamine hippurate, trimethoprim and trimethoprim-sulfamethoxazole on the control of recurrent urinary tract infection. Ann Clin Res 6:285-289, 1974 MedlineGoogle Scholar10. MUSHERGRIFFITHTYLER DDM: Potentiation of the antibacterial effect of methenamine by acetohydroxamic acid. Antimicrob Agents Chemother 5:101-105, 1974 CrossrefMedlineGoogle Scholar11. ARONSONMEDALIAGRIFFEL MOB: Prevention of ascending pyelonephritis in mice by urease inhibitors. Nephron 12:94-104, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Hospital Madison, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySecretagogues and Cardiac RiskUniversity Group Diabetes Program—“Déjà Vu All Over Again”?Electrochemical behavior of nitrofurantoin and assay of its formulationsUrinary Tract Infections in Men Epidemiology, Pathophysiology, Diagnosis, and TreatmentBenjamin A. Lipsky, MDUrinary tract infection in old ageWirksamkeit antibiotischer Behandlung und Prophylaxe bei Kindern mit nicht-obstruktiver HarnwegsinfektionRecurrent urinary tract infections in men: an assessment of contemporary treatmentTwenty Years of Research on Urinary Tract Infections in Children: Progress and Problems 1 August 1975Volume 83, Issue 2Page: 273-274KeywordsBladderCathetersChemotherapyDrugsLesions Issue Published: 1 August 1975 PDF downloadLoading ...