tbuckley/cabot-search huggingface dataset:
1001-8 Long-term results of ISAR-REACT: A randomized trial evaluating Abciximab in patients with elective percutaneous coronary intervention after pretreatment with a high loading dose of clopidogrel
Authors: Helmut Schuhlen, Adnan Kastrati, Julinda Mehilli, Josef Dirschinger, Franz Dotzer, Jurrien ten Berg, Franz-Josef Neumann, Peter B Berger, Albert Schomig
Journal: Journal of the American College of Cardiology (2004)
A Common Problem with Therapy for HIV Infection
Authors: Marcial Delgado Fernández, José Luis Zambrana García, Felipe Díez García
Journal: Annals of Internal Medicine (2000)

Letters16 May 2000A Common Problem with Therapy for HIV InfectionMarcial Delgado Fernández, MD, José Luis Zambrana García, MD, and Felipe Díez García, MDMarcial Delgado Fernández, MDHospital de Poniente; 04700 El Ejido, Almería, Spain (Delgado, Fernández)Hospital de Poniente; 04700 El Ejido, Almería, Spain (Luis, García)Hospital de Poniente; 04700 El Ejido, Almería, Spain (D, García)Search for more papers by this author, José Luis Zambrana García, MDHospital de Poniente; 04700 El Ejido, Almería, Spain (Delgado, Fernández)Hospital de Poniente; 04700 El Ejido, Almería, Spain (Luis, García)Hospital de Poniente; 04700 El Ejido, Almería, Spain (D, García)Search for more papers by this author, and Felipe Díez García, MDHospital de Poniente; 04700 El Ejido, Almería, Spain (Delgado, Fernández)Hospital de Poniente; 04700 El Ejido, Almería, Spain (Luis, García)Hospital de Poniente; 04700 El Ejido, Almería, Spain (D, García)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-10-200005160-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:During the past 3 years, techniques of quantifying HIV viral load have allowed us to assess our success in the control of viral replication resulting from drug therapy. The immunologic status of HIV-infected patients has dramatically improved in all countries where protease inhibitors have been accessible (1).However, treatment of HIV infection imposes an enormous economic burden on national health services and health insurance companies responsible for providing care to these patients. In Spain, the National Health Service provides appropriate drugs to these patients on a monthly basis. Unfortunately, frequent modifications of drug regimens are necessitated as ...Reference1. Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents. 5 May 1999. Centers for Disease Control and Prevention National Prevention Information Network. www.cdcnpin.org. Google Scholar Author, Article, and Disclosure InformationAuthors: Marcial Delgado Fernández, MD; José Luis Zambrana García, MD; Felipe Díez García, MDAffiliations: Hospital de Poniente; 04700 El Ejido, Almería, Spain (Delgado, Fernández)Hospital de Poniente; 04700 El Ejido, Almería, Spain (Luis, García)Hospital de Poniente; 04700 El Ejido, Almería, Spain (D, García) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 May 2000Volume 132, Issue 10Page: 846KeywordsBlistersDrug therapyDrugsHIV infectionsMedical servicesPatientsProtease inhibitorsTreatment guidelinesViral loadViral replication ePublished: 15 August 2000 Issue Published: 16 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Non-invasive ventilation
Authors: E F Nash
Journal: Thorax (2002)

Non-invasive ventilation (NIV) has been shown to be of benefit in the treatment of decompensated respiratory acidosis due to an exacerbation of chronic obstructive pulmonary disease (COPD).1–3 The reduction in the need for intubation and in mortality offered by this treatment make it at least a useful initial therapy …
Groups Push Physicians and Patients to Embrace Electronic Health Records
Authors: Tracy Hampton
Journal: JAMA (2008)

EXPERTS AGREE THAT ELECTRONIC health records can save lives and money by reducing the costs and harms associated with medical errors and by cutting down on redundant tests and procedures. But a number of unresolved issues, including affordability and privacy concerns, have made hospitals, physicians, and patients slow to adopt them. Although those hurdles remain, governmentandnonprofitorganizations, as well as technology giants such as Microsoft and Google, are attempting to drive the technology forward. What is envisionedisaneasilyaccessibleelectronicsystemthat,bycoordinatingthestorageand retrievalof individuals’healthrecords, increasesefficiency,reducescosts,andpromotes standardization of care.
Principles of adoptive T cell cancer therapy
Authors: Carl H. June
Journal: Journal of Clinical Investigation (2007)

The transfusion of T cells, also called adoptive T cell therapy, is an effective treatment for viral infections and has induced regression of cancer in early-stage clinical trials. However, recent advances in cellular immunology and tumor biology are guiding new approaches to adoptive T cell therapy. For example, use of engineered T cells is being tested as a strategy to improve the functions of effector and memory T cells, and manipulation of the host to overcome immunotoxic effects in the tumor microenvironment has led to promising results in early-stage clinical trials. Challenges that face the field and must be addressed before adoptive T cell therapy can be translated into routine clinical practice are discussed.
ABC of resuscitation. Advanced life support in general practice.
Authors: B Steggles
Journal: BMJ (1986)

The two previous articles have explained the procedures for advanced life support in hospital: these may seem complicated and deter the general practitioner.He should not be deterred because, with some modifications, advanced life support may still be applied effectively before the patient reaches hospital.The general practitioner may be confronted by an emergency unexpectedly, and it is as well to be prepared and equipped and to be up to date with resuscitation techniques.None ofthis is difficult, and it is far better to be able to feel confident to attempt resuscitation than to feel helpless.Advanced life support follows on from the basic life support procedures already described and includes advanced airway care, maintenance ofcirculatory volume, and defibrillation when appropriate.Defibrillation is not difficult.It does not require an ability to make complicated diagnoses from an electrocardiogram-only the ability to recognize five basic rhythm disturbances or the clinical fact ofcardiac arrest-and failure to correct ventricular fibrillation results in death anyway.
THE ANTENATAL TREATMENT OF HEMOPHILIA.
Authors: J. W. BALLANTYNE
Journal: JAMA (1901)

In the absence of accurate antenatal diagnosis, cases in which the effects of antenatal treatment can be tested are few and far between. The well-known tendency of morbid fetal states to repeat themselves more than once in the reproductive history of the same mother gives, however, a possible opportunity of trying to influence beneficially the health of the unborn infant; further, the hereditary character of some of the maladies which thus tend to repeat themselves increases the probability of the antenatal diagnosis, although it must be confessed that it diminishes or appears to diminish the chances of successful therapeutics. Hemophilia is a malady which fulfills the conditions which have been stated above. It is very clearly and persistently hereditary, and it also shows family prevalence. As a test case, then, it has its advantages. Given a woman who comes of hemophilic stock, who has a hemophilic father or brothers, there
Their lordships on medical research
Authors: J. Walton
Journal: BMJ (1995)

did it?"and "How do we stop it?"may be of little relevance after an earthquake, they are uppermost in the mind of anyone subject to continual bom- bardment and ethnic cleansing.Failure to engage with these issues can increase a sense of victimhood and disempowerment; and attempts to remain politically neutral in the face of genocide may well be construed as tacit collaboration with the aggessor and make effective therapeutic work impossible.Human identity rests on the network of social relations that we build around ourselves: the tie of family, work, and community, and the emotional bond we make with our physical environment.One might argue that the main psychic injury of war is the disruption of those ties, the destruction of identity through the destruction of our social world.Thus any thorough evaluation of psycho- logical treatments for traumatic stress should compare their effectiveness with the impact on mental health of non-psychological interventions such as community redevelopment projects.Only then can scarce resources be allocated in the most appropriate way.
A National Long-term Care Program for the United States
Authors: Charlene Harrington
Journal: JAMA (1991)

The financing and delivery of long-term care (LTC) need substantial reform. Many cannot afford essential services; age restrictions often arbitrarily limit access for the nonelderly, although more than a third of those needing care are under 65 years old; Medicaid, the principal third-party payer for LTC, is biased toward nursing home care and discourages independent living; informal care provided by relatives and friends, the only assistance used by 70% of those needing LTC, is neither supported nor encouraged; and insurance coverage often excludes critically important services that fall outside narrow definitions of medically necessary care. We describe an LTC program designed as an integral component of the national health program advanced by Physicians for a National Health Program. Everyone would be covered for all medically and socially necessary services under a single public plan, federally mandated and funded but administered locally. An LTC payment board in each state would contract directly with providers through a network of local public agencies responsible for eligibility determination and care coordination. Nursing homes, home care agencies, and other institutional providers would be paid a global budget to cover all operating costs and would not bill on a per-patient basis. Alternatively, integrated provider organizations could receive a capitation fee to cover a broad range of LTC and acute care services. Individual practitioners could continue to be paid on a fee-for-service basis or could receive salaries from institutional providers. Support for innovation, training of LTC personnel, and monitoring of the quality of care would be greatly augmented. For-profit providers would be compensated for past investments and phased out. Our program would add between $18 billion and $23.5 billion annually to current spending on LTC. Polls indicate that a majority of Americans want such a program and are willing to pay earmarked taxes to support it. (<i>JAMA</i>. 1991;266:3023-3029)
ERS guidelines, statements and technical standards published in the<i>ERJ</i>in 2014: a year in review
Authors: Guy G. Brusselle, Mina Gaga
Journal: European Respiratory Journal (2015)

The number of scientific journals and the number of publications regarding biomedical research is rapidly increasing at an almost exponential rate. Therefore, there is a huge need for physicians, allied healthcare professionals, researchers and patients to have access to clear and valid syntheses of the available evidence on the management of specific diseases or research topics within respiratory medicine and science. There are at least two different approaches to provide a synopsis on the diagnosis, prevention or treatment of a respiratory disease or health problem. In the first approach, one author or a few authors provide a narrative review of the management of the respiratory disease of interest, without performing a comprehensive systematic review of the literature and without providing explicit recommendations for clinical practice. Although the authors are often experts in their field, they do not aim to search, grasp and cite all available evidence, implicating that this approach is prone to systematic errors or biases (encompassing publication bias and reporting bias). In the second approach, a multidisciplinary panel of experts ( e.g. a European Respiratory Society (ERS) Task Force) searches in a systematic and transparent manner for all available evidence on the respiratory disease, the diagnostic test or the treatment of interest. Within ERS Task Forces, the Chairs and members are assisted in the methodological processes required for the development of statements and guidelines by experts ( i.e. methodologists). Whereas the comprehensive scientific review of the literature by an ERS Task Force forms the basis of an official ERS statement or technical standard, the development of an ERS clinical practice guideline requires several crucial additional steps. The aims of this editorial are three-fold: 1) to explain the differences between the three possible outcomes of an ERS Task Force; a guideline, a statement or a technical standard; 2) to provide a concise overview of several important ERS Task Force documents published in the European Respiratory Journal ( ERJ ) in the past year [1–6]; and 3) to give some insights into the development and publication processes of ERS guidelines, statements and technical standards. 2014: a year in review of ERS guidelines, statements and technical standards <http://ow.ly/HnGDs>
Vermont's Suicide Rate
Authors: G. BIRKHEAD
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Vermont's Suicide RateG. BIRKHEAD, M.D., M.P.H., R. L. VOGT, M.D., S. G. PARREN, M.S.G. BIRKHEAD, M.D., M.P.H.Search for more papers by this author, R. L. VOGT, M.D.Search for more papers by this author, S. G. PARREN, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-308 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We appreciate the eloquent interest in the health of the citizens of our state expressed by Dr. Donze in the Ad Libitum section of the April issue (1). Indeed, Vermont has a high suicide rate when compared with the United States as a whole. In 1983, the latest year for which national data are available, Vermont's age-adjusted suicide rate was 13.3/100 000 while the national rate (2) was 11.4/100 000 overall and 12.2/100 000 for whites, perhaps a fairer comparison given Vermont's racial and ethnic makeup. Vermont has the second highest suicide rate in the eastern United...References1. DONZE R. Vermont has a high suicide rate [Ad libitum]. Ann Intern Med. 1986;104:592. LinkGoogle Scholar2. . Monthly Vital Statistics Report. 1985;34(6 suppl 2):36. Google Scholar3. . Suicide Surveillance, 1970-1980. Atlanta, Georgia: Centers for Disease Conrol; 1985:21. Google Scholar4. . Public Health Statistics Bulletin. 1984; (July):6. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: G. BIRKHEAD, M.D., M.P.H.; R. L. VOGT, M.D.; S. G. PARREN, M.S.Affiliations: Vermont Department of Health Burlington, VT 05402 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1986Volume 105, Issue 2Page: 308-308KeywordsSuicide ePublished: 1 December 2008 Issue Published: 1 August 1986 PDF downloadLoading ...
Ten Years&amp;rsquo; Experience with the Submucosally Embedded in situ Appendix in Continent Cutaneous Diversion
Authors: Elmar W. Gerharz, Ulrich N. K&ouml;hl, Michael D. Melekos, Roland Bonfig, Karl Weing&auml;rtner, Hubertus Riedmiller
Journal: European Urology (2001)
RETRACTED: miR-221&amp;222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation
Authors: Michela Garofalo, Gianpiero Di Leva, Giulia Romano, Gerard Nuovo, Sung-Suk Suh, Apollinaire Ngankeu, Cristian Taccioli, Flavia Pichiorri, Hansjuerg Alder, Paola Secchiero, Pierluigi Gasparini, Arianna Gonelli, Stefan Costinean, Mario Acunzo, Gerolama Condorelli, Carlo Maria Croce
Journal: Cancer Cell (2009)
"THERAPEUTIC RESULTS WITH CONCENTRATED SCARLET FEVER ANTITOXIN"
Authors: Abraham Zingher
Journal: JAMA (1926)

<h3>To the Editor:</h3> —The discussion by Dr. George F. Dick of the paper by the Dicks on "Therapeutic Results with Concentrated Scarlet Fever Antitoxin" (The Journal, Nov. 28, 1925) followed a paper which I presented at the same meeting of the Section on Pharmacology and Therapeutics in Atlantic City last May. My paper has not yet been published and my discussion of Dr. Dick's paper was not included. In the article entitled "Streptococcus Toxin in Preventive Immunization" (The Journal, Feb. 16, 1924), the Dicks reported typical moderate to severe scarlet fever-like symptoms following injections of large doses of the streptococcus toxin, symptoms exactly like those described by Gabritschewsky in the<i>Berliner klinische Wochenschrift</i>, May 6, 1907, after the use of his toxin-vaccine. At that time no other attempt was made by the Dicks to recommend any special dosage, and as I commenced my work with toxin immunization soon after the
Livedo reticularis and nodules due to cholesterol embolism in the lower extremities
Authors: P. DESCHAMPS, D. LEROY, J. C. MANDARD, J. F. HERON, P. LAURET
Journal: British Journal of Dermatology (1977)

Journal Article Livedo reticularis and nodules due to cholesterol embolism in the lower extremities Get access P. DESCHAMPS, P. DESCHAMPS Department of Dermatology, Centre Hospitalier et Universitaire 14033 Caen Cedex, France Search for other works by this author on: Oxford Academic Google Scholar D. LEROY, D. LEROY Department of Dermatology, Centre Hospitalier et Universitaire 14033 Caen Cedex, France Search for other works by this author on: Oxford Academic Google Scholar J. C. MANDARD, J. C. MANDARD Department of Dermatology, Centre Hospitalier et Universitaire 14033 Caen Cedex, France Search for other works by this author on: Oxford Academic Google Scholar J. F. HERON, J. F. HERON Department of Dermatology, Centre Hospitalier et Universitaire 14033 Caen Cedex, France Search for other works by this author on: Oxford Academic Google Scholar P. LAURET P. LAURET Department of Dermatology, Hôpital Charles‐Nicolle, 76038 Rouen Cedex, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue 1, 1 July 1977, Pages 93–97, https://doi.org/10.1111/j.1365-2133.1977.tb15434.x Published: 01 July 1977
β <sub>2</sub> -Adrenergic Receptor Polymorphisms and Risk of Incident Cardiovascular Events in the Elderly
Authors: Susan R. Heckbert, Lucia A. Hindorff, Karen L. Edwards, Bruce M. Psaty, Thomas Lumley, David S. Siscovick, Zhonghua Tang, J. Peter Durda, Richard A. Kronmal, Russell P. Tracy
Journal: Circulation (2003)

Background— Genetic polymorphisms at codons 16 and 27 of the β 2 -adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study. Methods and Results— A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the β 2 -adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of β 2 -adrenergic receptor genotype with ischemic stroke or combined cardiovascular events. Conclusions— The Glu27 allele of the β 2 -adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.
Bronchial hyperresponsiveness and adult onset wheeze: the influence of atopy
Authors: C. Bodner, D. Godden, S Ross, J Little, J.g Douglas, J Legge, A Seaton, J Friend
Journal: European Respiratory Journal (1999)

The commonly held belief that adult onset wheezing illness is primarily nonatopic in nature suggests that the role of atopy in the pathophysiology of bronchial hyperresponsiveness (BHR) in adult onset wheeze may be minimal. This study examined risk factors for BHR (BHR: provocative dose causing a 20% fall in forced expiratory volume in one second PD20 &lt; or =16.38 micromol methacholine) among 82 subjects with adult onset wheeze and among 191 subjects who had never wheezed. Subjects were identified from a cohort of subjects aged 39-45 yrs who were known to have had no childhood wheeze and who were involved in a 30 yr follow-up survey. Risk factors for BHR were examined among all subjects with BHR and among subjects with BHR stratified according to whether or not they had ever wheezed. The prevalence of BHR was 40% (33/82) among the subjects with adult onset wheeze and 11% (21/191) among the subjects who had never wheezed. Lower baseline lung function (odds ratio (OR) = 0.94; 95% confidence interval (CI) = 0.92-0.97 per unit forced expiratory volume (FEV1)% predicted) and atopy (OR = 7.23; CI = 2.53-20.64 for all three measures of atopic compared to nonatopic) were associated with BHR, while smoking and family history showed no statistically significant relation to BHR. This pattern was also apparent in analyses stratified by symptom status. A family history of atopy increased the risk that BHR was accompanied by wheezing symptoms (OR = 4.75; CI = 1.53-14.72 for more than one affected relative compared to no affected relatives). These findings suggest that atopy is associated with bronchial hyperresponsiveness in adults known to have had no childhood wheeze. A familial factor reflecting genetic influences and/or shared environmental factors may influence whether bronchial hyperresponsiveness is associated with symptoms.
Public reporting and case selection for percutaneous coronary interventions: an analysis from two large multicenter PCI databases
Authors: Mauro Moscucci, Kim A. Eagle, David Share, Anthony C. DeFranco, Babak A. Vakili, Vivian L. Clark, James N. Slater, Warren Sherman, Kumar L. Ravi, Timothy A. Sanborn, Stephen J. Green, David L. Brown
Journal: Journal of the American College of Cardiology (2002)
Factors Affecting Admission to a Coronary Care Unit
Authors: I. C. Gilchrist
Journal: BMJ (1971)

Of 103 patients with suspected myocardial infarction admitted to an intensive care unit in a general hospital half were admitted within four and a half hours of the onset of symptoms. In general, patients who attended the casualty department were under intensive care sooner than patients who sought attention from their general practitioner before admission. Patients who were seen by a locum from the emergency treatment service at night or weekends were more likely to remain at home until seen the next day by their own general practitioner, compared with patients seen by their own general practitioner initially.