tbuckley/cabot-search huggingface dataset:
Left ventricular dysfunction in patients with angina pectoris, normal epicardial coronary arteries, and abnormal vasodilator reserve.
Authors: R O Cannon, R O Bonow, S L Bacharach, M V Green, D R Rosing, M B Leon, R M Watson, S E Epstein
Journal: Circulation (1985)

Thirty-three patients with chest pain despite angiographically normal coronary arteries underwent both coronary flow studies during pacing and resting and exercise gated blood pool scintigraphy. During atrial pacing after administration of ergonovine, those patients developing their typical chest pain demonstrated significantly lower great cardiac vein flow (97 +/- 31 vs 150 +/- 33 ml/min, p less than .001), higher coronary resistance (1.27 +/- 0.43 vs 0.77 +/- 0.18 mm Hg/ml/min, p less than .005), and less lactate consumption (30.5 +/- 22.0 vs 69.7 +/- 41.1 mM . ml/min, p less than .005) and a higher left ventricular end-diastolic pressure after pacing (20 +/- 4 vs 12 +/- 1, p less than .001) compared with those without pain and in the absence of significant luminal narrowing of the epicardial coronary arteries. The 26 patients with abnormal vasodilator reserve demonstrated reduced left ventricular ejection fraction during exercise (58 +/- 8%) compared with the seven patients with appropriate vasodilator reserve (66 +/- 4%, p less than .05) and with a group of 52 control patients of similar age and sex distribution and free of known heart disease (66 +/- 10%, p less than .001). In addition, 12 of the 26 patients with abnormal vasodilator reserve demonstrated exercise-induced regional wall motion abnormalities. Many of these patients also manifested impaired left ventricular diastolic filling at rest compared with the control subjects (peak filling rate 2.6 +/- 0.7 vs 3.2 +/- 0.7 end-diastolic volume/sec, p less than .005). Thus, patients with chest pain resulting from abnormal vasodilator reserve demonstrate abnormalities of left ventricular systolic and diastolic function suggestive of myocardial ischemia.
Terminal Sedation in the Netherlands
Authors: Shimon M. Glick
Journal: Annals of Internal Medicine (2004)

Letters21 December 2004Terminal Sedation in the NetherlandsShimon M. Glick, MDShimon M. Glick, MDFrom Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-12-200412210-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent article by Rietjens and colleagues on terminal sedation (1) adds to the disturbing data from the Netherlands. In addition to several thousand cases of active euthanasia reported annually, we are now told about another approximately 14 000 preceded by terminal sedation, which, as defined by the authors, invariably includes withdrawal of fluids and nutrition. Since suffering is virtually eliminated by the sedation itself, the purpose of fluid and nutrition withdrawal can only be to hasten death. Thus, at the very least (because of probable significant underreporting), close to 20 000 Dutch patients have their deaths actively and ...References1. Rietjens JA, van der Heide A, Vrakking AM, Onwuteaka-Philipsen BD, van der Maas PJ, van der Wal G. Physician reports of terminal sedation without hydration or nutrition for patients nearing death in the Netherlands. Ann Intern Med. 2004;141:178-85. [PMID: 15289214] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPhysician Reports of Terminal Sedation without Hydration or Nutrition for Patients Nearing Death in the Netherlands Judith A.C. Rietjens , Agnes van der Heide , Astrid M. Vrakking , Bregje D. Onwuteaka-Philipsen , Paul J. van der Maas , and Gerrit van der Wal Terminal Sedation in the Netherlands Zbigniew Zylicz Terminal Sedation in the Netherlands Judith A.C. Rietjens , Agnes van der Heide , and Gerrit van der Wal Metrics Cited ByJustifying continuous sedation until death: A focus group study in nursing homes in Flanders, BelgiumThe Moral Difference or Equivalence Between Continuous Sedation Until Death and Physician-Assisted Death: Word Games or War Games?Questions éthiques associées à la pratique de la sédation en phase terminalePalliative Sedation Definition, Practice, Outcomes, and Ethics 21 December 2004Volume 141, Issue 12Page: 966KeywordsEuthanasiaNutritionPalliative careSedation ePublished: 21 December 2004 Issue Published: 21 December 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
Authors: Omar Abdel-Wahab, Ann Mullally, Cyrus Hedvat, Guillermo Garcia-Manero, Jay Patel, Martha Wadleigh, Sebastien Malinge, JinJuan Yao, Outi Kilpivaara, Rukhmi Bhat, Kety Huberman, Sabrena Thomas, Igor Dolgalev, Adriana Heguy, Elisabeth Paietta, Michelle M. Le Beau, Miloslav Beran, Martin S. Tallman, Benjamin L. Ebert, Hagop M. Kantarjian, Richard M. Stone, D. Gary Gilliland, John D. Crispino, Ross L. Levine
Journal: Blood (2009)
Cimetidine and Theophylline
Authors: Richard P. Lofgren, Reid A. Gilbertson
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 March 1982Cimetidine and TheophyllineRICHARD P. LOFGREN, M.D., REID A. GILBERTSONRICHARD P. LOFGREN, M.D.Search for more papers by this author, REID A. GILBERTSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-378_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We were interested in the article by Reitberg and associates (1) describing a decreased theophylline clearance in six volunteers given cimetidine. We recently cared for a patient whose serum aminophylline concentration dramatically increased after the administration of cimetidine.A 71-year-old woman had a history of chronic obstructive pulmonary disease associated with severe steroid-dependent bronchospasm, atherosclerotic heart disease, Hodgkin disease in remission after chemotherapy, and peptic ulcer disease. She was hospitalized with an acute exacerbation of her lung disease and treated with intravenous aminophylline, 40 mg/h, which yielded a serum concentration of 20 µg/mL. After 2 days, the...References1. REITBERGBERNHARDSCHENTAG DHJ. Alteration of theophylline clearance and half-life by cimetidine in normal volunteers. Ann Intern Med. 1981;96:582-5. LinkGoogle Scholar2. VAN DELLEN R. Theophylline: practical application of new knowledge. Mayo Clin Proc. 1979;54:733-45. MedlineGoogle Scholar3. ZWILLICHSUTTONNEFFCOHNMATTHAYWEINBERGER CFTWRM. Theophylline-induced seizures in adults. Correlation with serum concentrations. Ann Intern Med. 1975;82:784-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD P. LOFGREN, M.D.; REID A. GILBERTSONAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug Interactions and Obstetric AnesthesiaDrug Interactions with Agents Used to Treat Gastrointestinal DiseaseDrug Interactions with Agents Used in Respiratory DiseaseCentral Nervous System Reactions to Histamine-2 Receptor BlockersThomas G. Cantú, PharmD, Joan S. Korek, PharmDConcerning drug interactions with theophyllineThe Effect of Route of Administration on the Cimetidine-Theophylline Drug InteractionDrug Concentration MonitoringSafety perspectives on parenteral H2-receptor antagonistsAminophylline ToxicityThe Hepatic and Renal Mechanisms of Drug Interactions with CimetidineSicherheitsprofil des H2-Blockers RaniditinCimetidine-drug interactionsRanitidine HydrochlorideDrug Interactions and Obstetric Anesthesia 1 March 1982Volume 96, Issue 3Page: 378-378KeywordsAttentionCardiovascular therapyChemotherapyChronic obstructive pulmonary diseaseHodgkin lymphomaLungsPeptic ulcers ePublished: 1 December 2008 Issue Published: 1 March 1982 PDF downloadLoading ...
Impaired Vascular Growth in Late Adolescence After Intrauterine Growth Restriction
Authors: J. Brodszki, T. Länne, K. Maršál, D. Ley
Journal: Circulation (2005)

Abnormal blood flow in a fetus small for gestational age indicates true fetal intrauterine growth restriction (IUGR). We tested the hypothesis that IUGR with abnormal fetal blood flow is associated with long-term abnormal vascular morphology and function in adolescence.In a prospective study, vascular mechanical properties of the common carotid artery (CCA), abdominal aorta, and popliteal artery (PA) were assessed by echo-tracking sonography in 21 adolescents with IUGR and abnormal fetal aortic blood flow and in 23 adolescents with normal fetal growth and normal fetal aortic blood flow. Endothelium-dependent and -independent vasodilatation of the brachial artery was measured by high-resolution ultrasound. After adjustment for body surface area and sex, the IUGR group had significantly smaller end-diastolic vessel diameters than the referents in the abdominal aorta and PA (mean difference, 1.7 mm [95% CI, 0.62 to 2.74] and 0.6 mm [95% CI, 0.25 to 1.02], respectively) (P=0.003 and P=0.002, respectively), with a similar trend in the CCA (P=0.09). A higher resting heart rate was observed in the IUGR group (P=0.01). No differences were found in stiffness or in endothelium-dependent and -independent vasodilatation between the 2 groups.IUGR caused by placental insufficiency appears to be associated with impaired vascular growth persisting into young adulthood in both men and women. The smaller aortic dimensions and the higher resting heart rate seen in adolescents with previous IUGR may be of importance for future cardiovascular health.
Regression of Cellular Hypertrophy After Left Ventricular Assist Device Support
Authors: Andreas Zafeiridis, Valluvan Jeevanandam, Steven R. Houser, Kenneth B. Margulies
Journal: Circulation (1998)

Background —Although multiple studies have shown that the left ventricular assist device (LVAD) improves distorted cardiac geometry, the pathological mechanisms of the “reverse remodeling” of the heart are unknown. Our goal was to determine the effects of LVAD support on cardiac myocyte size and shape. Methods and Results —Isolated myocytes were obtained at cardiac transplantation from 30 failing hearts (12 ischemic, 18 nonischemic) without LVAD support, 10 failing hearts that received LVAD support for 75±15 days, and 6 nonfailing hearts. Cardiac myocyte volume, length, width, and thickness were determined by use of previously validated techniques. Isolated myocytes from myopathic hearts exhibited increased volume, length, width, and length-to-thickness ratio compared with normal myocytes ( P &lt;0.05). However, there were no differences in any parameter between myocytes from ischemic and nonischemic cardiomyopathic hearts. Long-term LVAD support resulted in a 28% reduction in myocyte volume, 20% reduction in cell length, 20% reduction in cell width, and 32% reduction in cell length-to-thickness ratio ( P &lt;0.05). In contrast, LVAD support was associated with no change in cell thickness. These cellular changes were associated with reductions in left ventricular dilation and left ventricular mass measured echocardiographically in 6 of 10 LVAD-supported patients. Conclusions —These studies suggest that the regression of cellular hypertrophy is a major contributor to the “reverse remodeling” of the heart after LVAD implantation. The favorable alterations in geometry that occur in parallel fashion at both the organ and cellular levels may contribute to reduced wall stress and improved mechanical performance after LVAD support.
Acupuncture versus Placebo for the Treatment of Chronic Mechanical Neck Pain
Authors: Peter White, George Lewith, Phil Prescott, Joy Conway
Journal: Annals of Internal Medicine (2004)

Background: Despite substantial increases in its popularity and use, the efficacy of acupuncture for chronic mechanical neck pain remains unproved. Objective: To compare acupuncture and placebo for neck pain. Design: A randomized, single-blind, placebo-controlled, parallel-arm trial with 1-year follow-up. Setting: The outpatient departments of 2 major hospitals in the United Kingdom, 1999 to 2001. Patients: 135 patients 18 to 80 years of age who had chronic mechanical neck pain. Eleven patients withdrew from treatment, and 124 completed the primary end point. Measurements: The primary outcome was pain 1 week after treatment, according to a visual analogue scale. Secondary outcomes were pain at other time points, score on the Neck Disability Index and the Short Form-36, and use of analgesic medications. Interventions: Patients were randomly assigned to receive, over 4 weeks, 8 treatments with acupuncture or with mock transcutaneous electrical stimulation of acupuncture points using a decommissioned electroacupuncture stimulation unit. Results: Both groups improved statistically from baseline, and acupuncture and placebo had similar credibility. For the primary outcome (weeks 1 to 5), a statistically significant difference in visual analogue scale score in favor of acupuncture (6.3 mm [95% CI, 1.4 to 11.3 mm]; P = 0.01) was observed between the 2 study groups, after adjustment for baseline pain and other covariates. However, this difference was not clinically significant because it demonstrated only a 12% (CI, 3% to 21%) difference between acupuncture and placebo. Secondary outcomes showed a similar pattern. Limitations: All treatments were provided by 1 practitioner. Although the control was credible, it did not mimic the process of needling. A nonintervention group was not present to control for regression to the mean. Conclusions: Acupuncture reduced neck pain and produced a statistically, but not clinically, significant effect compared with placebo. The beneficial effects of acupuncture for pain may be due to both nonspecific and specific effects.
Is this the right way?
Authors: D R Rimmer
Journal: BMJ (2000)

Six of us caught the Sunday evening train from Manchester to Euston, the hordes from the north eager to enjoy the delights of London at the General Medical Council's expense. Train tickets, hotel in the west end, expenses—definitely better than working. We all looked forward to three exciting days in London away from the drudgery of home life.

> As we had been asked to help why did we feel like the accused? 

We were required to attend as witnesses to the GMC, which was investigating an incident concerning an ex-colleague. This had occurred 18 months previously, and at the time it had been fully investigated by the trust and the doctor had been dismissed. A full appeal held by the trust confirmed the decision, and it was thought that the GMC should be informed; hence the present inquiry. Originally, 15 people were scheduled to attend, but this had been whittled down to the essential six.

As we …
Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
Authors: Neil E. Kay, Susan M. Geyer, Timothy G. Call, Tait D. Shanafelt, Clive S. Zent, Diane F. Jelinek, Renee Tschumper, Nancy D. Bone, Gordon W. Dewald, Thomas S. Lin, Nyla A. Heerema, Lisa Smith, Michael R. Grever, John C. Byrd
Journal: Blood (2006)
A survey of approach to wound healing by secondary intention among British Society for Dermatological Surgery members
Authors: A. Lally, R. Turner
Journal: British Journal of Dermatology (2007)

Journal Article A survey of approach to wound healing by secondary intention among British Society for Dermatological Surgery members Get access A. Lally, A. Lally Department of Dermatology, Churchill Hospital, Oxford OX3 7LJ, U.K. E‐mail: Aoife.Lally@orh.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar R. Turner R. Turner Department of Dermatology, Churchill Hospital, Oxford OX3 7LJ, U.K. E‐mail: Aoife.Lally@orh.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 3, 1 March 2007, Pages 575–576, https://doi.org/10.1111/j.1365-2133.2006.07657.x Published: 01 March 2007
COST UTILITY AND QUALITY OF LIFE IMPACT OF LEFT ATRIAL APPENDAGE CLOSURE COMPARED TO WARFARIN FOR STROKE PREVENTION IN ATRIAL FIBRILLATION
Authors: Vivek Reddy, Ronald L. Akehurst, Stacey L. Amorosi, Shannon Armstrong, Colin Taggart, Steve Beard, Chris Knight, David Holmes
Journal: Journal of the American College of Cardiology (2014)
Abstract 4179: Loss of Hsulf-1 promotes chemoresistance and tumorigenecity in ovarian cancer
Authors: Xiaoping He, Ashwani Khurana, Scott Kaufmann, Viji Shridhar
Journal: Cancer Research (2012)

Abstract Human Sulfatase1 enzyme (HSulf-1) is down-regulated in a majority of ovarian cancer cell lines and primary tumors, but the functional consequence of this downregulation remains unclear. Here, we show that down-regulation of HSulf-1 by RNA interference resulted in an elevated level of phosphorylated Erk and phosphorqylated Akt as well as decreased Bim level in OV202 ovarian cancer cells. Treatment with PD98059 (p-Erk inhibitor) but not LY90024 (PI3K inhibitor) resulted in increased Bim level in Hsulf-1 knockdown cells, suggesting that increased Erk pathway plays a more important role in modulating Bim level after loss of HSulf-1. Consistently, the results of real-time PCR confirmed that there was no significant change in the mRNA level of Bim after knockdown of HSulf-1 expression. When treated with CDDP, OV202 cells with knockdown of HSulf-1 displayed more resistance to drug-induced apoptosis, with IC50 value 3-fold higher than cells with non-targeting shRNA (NTC), while SKOV3 cells with overexpression of HSulf-1 were more sensitive to CDDP-induced apoptosis compared to the control cells. Moreover, HSulf-1 downregulated OV202 cells showed remarkable growth of colonies in soft agar compared to no colony growing with NTC cells. When injected subcutaneously, HSulf-1 ShRNA clones but not NTC cells formed xenogrfts in nude mice. Importantly, rescuing Bim expression in HSulf-1 shRNA cells not only endowed cells sensitivity to CDDP treatment, but also significantly decreased numbers of colony formation in soft agar and significantly retarded tumor growth in nude mice. Collectively, these results strongly suggest that down-regulation of HSulf-1 promotes chemoresistance and tumorigenicity in ovarian cancer cells through post-translational downregulation of Bim level. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4179. doi:1538-7445.AM2012-4179
NOSOLOGICAL ARRANGEMENT OF FEVERS, INTENDED AS A GUIDE TO DIAGNOSIS AND TREATMENT
Authors: T. Laycock
Journal: BMJ (1855)

and Lecturer on the Theory and Practice of Medicine at the York Medical SchooL Foux years ago a very able esay on the diagnosis of fevers appred in tle then current number of the Briti& and Forei!pn Xedico-Ckirurgical Review.The ymptoms of c fevers, heretofore confounded, were carefully and systematically reviewed, with the object of establishing the
PASSIVE IMMUNITY IN AVIAN MALARIA
Authors: Reginald D. Manwell, Frederick Goldstein
Journal: The Journal of Experimental Medicine (1940)

The effect of therapy with immune serum has been studied in thirty-two cases of Plasmodium circumflexum infection, all of them produced by blood inoculation. Eighteen of these cases never showed parasites, and seven others developed infections which were definitely milder than those of the controls. The therapeutic serum was in all cases obtained from chronic cases which had previously been superinfected to raise the immune titre. It seems justifiable to conclude that: 1. Passive immunity can be conferred in avian malaria, at least when caused by Plasmodium circumflexum just as it can be in certain types of monkey malaria, and perhaps in human malaria as well. 2. Whatever the nature of the protective substances present in the serum of chronic cases may be, they are present in very low concentration. Their concentration can be raised by superinfection, however. These substances may be strain-specific or species-specific, but the results of these experiments do not give any clear-cut answer to this question. 3. Serum therapy previous to infection seems to be more effective than when given afterward. 4. The administration of normal serum or even of physiological saline in a dosage comparable to that employed with the immune serum used in these experiments produced similar macroscopic changes in the size of the spleen. 5. Agglutination of cells parasitized by Plasmodium circumflexurn when mixed with immune serum was observed.
1051-132 S-nitric oxide-human serum albumin, a novel intravenous nitric oxide-donor, minimizes I/R injury after four hours of ischemia in an orthotopic heart transplant model in the pig
Authors: Roman Gottardi, Tomas Szerafin, Severin Semsroth, Harald Gasser, Seth Hallstroem, Rainald Seitelberger, Ernst Wolner, Bruno K Podesser
Journal: Journal of the American College of Cardiology (2004)
The Small Molecule Harmine Is an Antidiabetic Cell-Type-Specific Regulator of PPARγ Expression
Authors: Hironori Waki, Kye Won Park, Nico Mitro, Liming Pei, Robert Damoiseaux, Damien C. Wilpitz, Karen Reue, Enrique Saez, Peter Tontonoz
Journal: Cell Metabolism (2007)
A piece of my mind. An elegy
Authors: A. Wagner
Journal: JAMA (1989)

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