tbuckley/cabot-search huggingface dataset:
THE USE OF DISCARDED ANTITOXIN SERUM SYRINGES FOR AEROBIC AND ANAEROBIC CULTURE CONTAINERS
Authors: Emil Weiss
Journal: JAMA (1924)

The usual antitoxin serum syringe, after it has been used, can be cleaned and filled with bouillon or other fluid culture medium. With the plunger retracted, the cylinder filled with the culture medium to the desired level and the needle in place, the whole is then autoclaved. After sterilization, the needle is removed and the opening closed with hot paraffin. When it is desired to inoculate this culture, the needle is sterilized by boiling, and while it is hot the paraffin plug is punctured and the needle fixed in place over the end of the syringe. A necessary amount of the medium is expressed from the syringe, and the material from which the culture is to be made is sucked up into the cylinder. This can be used for blood cultures; venipunctures can be made directly with the needle, or for obtaining inoculum from any kind of material, pus or
Homozygosity mapping with SNP arrays confirms 3p21 as a recessive locus for gray platelet syndrome and narrows the interval significantly
Authors: Shay Fabbro, Walter H. A. Kahr, Jesse Hinckley, Kai Wang, Jack Moseley, Gi-Yung Ryu, Brie Nixon, James G. White, Thomas Bair, Brian Schutte, Jorge Di Paola
Journal: Blood (2011)
FEVER FOLLOWING TRANSCATHETER AORTIC VALVE IMPLANTATION: PREVALENCE, PATTERN AND RATE ATTRIBUTED TO AN INFECTIOUS ORIGIN
Authors: Eran Leshem–Rubinow, Sharon Amit, Arie Steinvil, Eyal Ben– Assa, Yigal Abramowitz, Gad Keren, Shmuel Banai, Ariel Finkelstein
Journal: Journal of the American College of Cardiology (2013)
Smoking and state of health.
Authors: R Balarajan, P Yuen, B R Bewley
Journal: BMJ (1985)

magnesaemia and hypocalcaemia,' and it is impossible to assess the true contribution to symptoms of either magnesium or calcium.Minor deficiencies of magnesium may cause severe hypo- calcaemia and hypokalaemia that are refractory to replacement treatment.Prompt replacement of magnesium may prevent pro- longed tetany, cardiac arrhythmias, and heart failure.
Intranasal fluticasone propionate for chronic eosinophilic rhinitis in patients with aspirin‐induced asthma
Authors: L. Mastalerz, M. Milewski, M. Duplaga, E. Nizankowska, A. Szczeklik
Journal: Allergy (1997)

We performed a double‐blind, crossover, placebo‐controlled study on the effect of fluticasone propionate (FP) treatment on chronic eosinophilic rhinosinusitis in 15 patients with aspirin‐induced asthma (AIA). There were 10 women and five men aged 32–60 years; average: 45 years. After a 10‐day run‐in period, patients underwent two 4‐week treatment courses (FP vs placebo), separated by a 2‐week washout interval. Clinical activity of FP was evaluated by daily measurement of peak nasal inspiratory flow (PNIF) and a scoring system of subjective symptoms. Nasal challenges with L‐lysine aspirin, using active anterior rhinomanometry, were performed at the entry and on the last day of each treatment period. Weekly mean values of symptom scores were generally lower and PNIF measurements higher during treatment with FP than with placebo. This difference was statistically significant for most recorded parameters for the whole 4‐week FP treatment. On average, the reactions evoked by aspirin nasal challenge were significantly shorter and milder after treatment with FP than with placebo. In 8/13 patients, FP completely prevented aspirin‐precipitated nasal reaction, whereas protection after placebo was observed in only 2/12 subjects ( P =0.004). We conclude that intranasal FP is an effective therapy for chronic eosinophilic rhinitis in patients with AIA.
Peripheral Vascular Endothelial Dysfunction in Patients With Angina Pectoris and Normal Coronary Arteriograms
Authors: John P Lekakis, Christos M Papamichael, Costas N Vemmos, Anastasios A Voutsas, Stamatios F Stamatelopoulos, Spyridon D Moulopoulos
Journal: Journal of the American College of Cardiology (1998)
Lovastatin Induces Apoptosis in Malignant Mesothelioma Cells
Authors: JEFFREY B. RUBINS, TODD GREATENS, ROBERT A. KRATZKE, ANNIE T. TAN, VITALY A. POLUNOVSKY, PETER BITTERMAN
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Malignant mesothelioma causes profound morbidity and nearly universal mortality that is refractory to conventional treatment with aggressive surgery, radiotherapy, or chemotherapy. We report that pharmacologic concentrations of lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor, induced apoptosis in human malignant mesothelioma cell lines. Mesothelioma cell viability was decreased in a dose-dependent manner by lovastatin (5 to 30 μ M). These effects were not reversed by exogenous growth factors or cholesterol, but were reversed by addition of 100 μ M mevalonate, confirming that lovastatin affected mesothelioma viability by inhibiting mevalonate synthesis. Lovastatin appeared to decrease mesothelioma viability by inducing apoptosis, as indicated by morphologic changes, histologic evidence of nuclear condensation and degeneration, and flow-cytometric analysis of DNA content. Lovastatin's effects on cell viability were partially reversed in the presence of farnesol, and treatment of mesothelioma cells with a specific farnesyl-protein transferase (FTP) inhibitor decreased cell viability and induced morphologic changes indistinguishable from those caused by lovastatin. In addition, lovastatin-treated cells showed translocation of ras guanosine triphosphate (GTP)-binding proteins from membrane to cytosolic fractions on Western blots, suggesting that lovastatin's effects on mesothelioma were mediated in part by disrupting acylation of GTP-binding proteins. Thus, lovastatin is a commercially available and clinically well-tolerated agent that reduces viability and induces apoptosis of mesothelioma cells, and may provide the basis for adjunctive treatments of patients with mesothelioma.
EUS-Guided Fine Aspiration Biopsy (FNA) - Indications and Hazards
Authors: K. Yasuda, M. Uno, K. Tanaka, M. Nakajima
Journal: Endoscopy (1998)

Ultrasound endoscopes with mechanical sector forward scan transducers make it possible to perform FNA under EUS, and drainage by tracing the needle in the ultrasound pictures by using the same monitor unit as for radial scan ultrasound endoscopes for EUS diagnosis. It is important to diagnose the lesions from the histological findings; however, there remain some problems about false negatives, histological diagnosis from very tiny materials, and the risk of disseminating the malignant cells by the procedure.
The Diversity of Neuronal Nicotinic Acetylcholine Receptors
Authors: Peter B. Sargent
Journal: Annual Review of Neuroscience (1993)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome.
Authors: H E Amos, B G Lake, J Artis
Journal: BMJ (1978)

The clinical distribution of an antibody to a metabolite of practolol was investigated, particularly in relation to the oculomucocutaneous syndrome. Serum samples were obtained from patients with and without a history of adverse reaction to practolol and two groups of control patients who had never taken the drug. Five patients also participated in a challenge study. The presence of the antibody was found to be related to practolol administration, and antibody activity could be increased by antigenic challenge. The role of this antibody in the pathogenesis of the oculomucocutaneous syndrome remains uncertain. The lesions may be the result of a hitherto unknown type of hypersensitivity response to practolol.
Open Treatment of Digital Tip Injuries
Authors: Dean S. Louis, Andrew K. Palmer, Richard E. Burney
Journal: JAMA (1980)

Thirty-three patients with 38 digital tip injuries were followed up for an average of eight months. All injuries had no bone exposed at the time of initial consultation and were treated by an open technique allowing secondary wound healing. Stationary two-point discrimination averaged 3.5 mm at follow-up examination. The final appearance of digits treated by this method was considered satisfactory by surgeons and patients alike. Comparison with other methods reconfirms that the open treatment of digital tip injuries in adults, where no bone is exposed, is a reasonable therapeutic alternative.  ( JAMA 244:697-698, 1980)
A Uniform Classification for Health Statistics.
Authors: Cressy L. Wilbur
Journal: JAMA (1900)

Lansing, Mich., Sept. 17, 1900. <h3>To the Editor:</h3> —Referring to your editorial inThe Journalof September 15, under the above title, I desire to say that it gives a somewhat imperfect impression of the nature and progress of the movement for the adoption of a uniform classification of causes of death, which is now an assured success. As the subject is one of very great practical importance, I trust that you will afford me the opportunity of making a more correct statement of the facts. In the first place the classification quoted by you on page 706 in the report of the proceedings of the International Congress of Hygiene and Demography is evidently one of the most condensed forms of the Bertillon classification, and does not fully exemplify its nature as usually employed. This classification is not merely the "Paris classification, but is the classification recommended for adoption
Indian Supreme Court rejects Novartis's appeal on drug patent
Authors: S. Arie
Journal: BMJ (2013)

India’s highest court has rejected efforts by the Swiss drug firm Novartis to patent its anticancer drug imatinib mesilate (marketed as Glivec) in the latest in a series of rulings in favour of India’s generic drug industry.

After a seven year legal battle the Supreme Court ruled that the drug was only an updated version of an existing one and as such was not innovative enough to merit a patent.

The ruling is seen as a crucial victory for manufacturers of generic drugs in the battle for India’s large and fast growing market. It means that …
Homozygous Deletion in <i>KVLQT1</i> Associated With Jervell and Lange-Nielsen Syndrome
Authors: Qiuyun Chen, Danmei Zhang, Robert L. Gingell, Arthur J. Moss, Carlo Napolitano, Silvia G. Priori, Peter J. Schwartz, Eileen Kehoe, Jennifer L. Robinson, Eric Schulze-Bahr, Qing Wang, Jeffrey A. Towbin
Journal: Circulation (1999)

Background —Long-QT (LQT) syndrome is a cardiac disorder that causes syncope, seizures, and sudden death from ventricular arrhythmias, specifically torsade de pointes. Both autosomal dominant LQT (Romano-Ward syndrome) and autosomal recessive LQT (Jervell and Lange-Nielsen syndrome, JLNS) have been reported. Heterozygous mutations in 3 potassium channel genes, KVLQT1, KCNE1 ( minK ), and HERG , and the cardiac sodium channel gene SCN5A cause autosomal dominant LQT. Autosomal recessive LQT, which is associated with deafness, has been found to occur with homozygous mutations in KVLQT1 and KCNE1 in JLNS families in which QTc prolongation was inherited as a dominant trait. Methods and Results —An Amish family with clinical evidence of JLNS was analyzed for mutations by use of single-strand conformation polymorphism and DNA sequencing analyses for mutations in all known LQT genes. A novel homozygous 2-bp deletion in the S2 transmembrane segment of KVLQT1 was identified in affected members of this Amish family in which both QTc prolongation and deafness were inherited as recessive traits. This deletion represents a new JLNS-associated mutation in KVLQT1 and has deleterious effects on the KVLQT1 potassium channel, causing a frameshift and the truncation of the KVLQT1 protein. In contrast to previous reports in which LQT was inherited as a clear dominant trait, 2 parents in the JLNS family described here have normal QTc intervals (0.43 and 0.44 seconds, respectively). Conclusions —A novel homozygous KVLQT1 mutation causes JLNS in an Amish family with deafness that is inherited as an autosomal recessive trait.
Role of bronchoalveolar lavage in children with lung disease
Authors: J Riedler, J Grigg, CF Robertson
Journal: European Respiratory Journal (1995)

The aim of the present study was to evaluate the clinical role of bronchoscopic and nonbronchoscopic bronchoalveolar lavage (BAL) in the diagnosis of infectious and interstitial lung disease in children. BAL was performed using three 1 mL.kg-1 aliquots of normal saline, with the flexible bronchoscope (Olympus 3.6 or 4.8 mm) wedged in a segmental or subsegmental bronchus of the lobe that showed most abnormality on chest radiograph. In seven children with severe diffuse lung disease who were intubated, a nonbronchoscopic suction catheter lavage was performed. Fluid cultures and cellularity were evaluated using identical methods for both techniques. Between January 1993 and April 1994, 41 BAL were performed in 32 children aged 2 months to 17 yrs (median 8 yrs). Of these lavages, 14 were in heart and heart-lung transplant recipients, 11 in children known to be immunocompromised, and 16 in children who had a lung biopsy for interstitial lung disease or who had presumed infective lung disease. Transbronchial biopsies (TBB) or open lung biopsies were performed coincident with 19 BAL procedures. In all transplant recipients without clinical symptoms, BAL and TBB cultures were negative and BAL cellularity was normal. TBB did not reveal infection or rejection in any of these patients. A diagnosis of infection was made by BAL in 1 out of 8 transplant recipients with clinical symptoms, and a diagnosis of rejection was made by TBB in 3 out of 8 patients. In 6 out of 11 BAL in immunocompromised children, an infectious agent was found in the BAL fluid. In three other patients who had an open lung biopsy, an interstitial lung disease was diagnosed. In these patients, BAL was abnormal but not diagnostic. In summary, BAL proved helpful in the diagnosis of infective lung disease, but had little value in the diagnosis of rejection or parenchymal noninfective lung disease in children.
How to Achieve a High-Performance Health Care System in the United States
Authors: Harvey S. Zarren
Journal: Annals of Internal Medicine (2008)

Letters6 May 2008How to Achieve a High-Performance Health Care System in the United StatesHarvey S. Zarren, MDHarvey S. Zarren, MDFrom Integrative Medicine Alliance, Arlington, MA 02474.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-9-200805060-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The single biggest issue in the quality of health care is the failure to provide adequate time for caregivers to spend with patients (and even with colleagues). Time for quality history assessment, thorough examinations, and careful formulation of diagnosis and treatment plans is not being reimbursed adequately.Single-payer health insurance makes great sense, and there must also be a shift in reimbursement away from testing and procedures toward adequate time for physicians and nurses to form the relationships with patients that are the essence of health care that heals. In 1994, the Pew-Fetzer Task Force report (1) ...Reference1. Pew-Fetzer Task Force on Advancing Psychosocial Health Education. Health Professions Education and Relationship-Centered Care. San Francisco: Pew Health Professions Commission; 1994. Google Scholar Author, Article, and Disclosure InformationAuthors: Harvey S. Zarren, MDAffiliations: From Integrative Medicine Alliance, Arlington, MA 02474.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAchieving a High-Performance Health Care System with Universal Access: What the United States Can Learn from Other CountriesHow to Achieve a High-Performance Health Care System in the United States Jack A. Ginsburg , Robert B. Doherty , and J. Fred Ralston Jr. How to Achieve a High-Performance Health Care System in the United States S. Ward Casscells and MG Elder Granger How to Achieve a High-Performance Health Care System in the United States Arvind R. Cavale How to Achieve a High-Performance Health Care System in the United States Richard S. Leff How to Achieve a High-Performance Health Care System in the United States Richard L. Cruess and Sylvia R. Cruess How to Achieve a High-Performance Health Care System in the United States Thomas James III Metrics 6 May 2008Volume 148, Issue 9Page: 711-712KeywordsCaregiversConflicts of interestHealth careHealth care qualityHealth insurance ePublished: 6 May 2008 Issue Published: 6 May 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Induction Cardiac Pacing: A New Approach
Authors: J. D. McArthur, J. D. Henderson, M. M. Mani, G. Cherian
Journal: BMJ (1973)

A new approach to induction cardiac pacing using a "skin tunnel" transformer has been developed and used in a patient. Initial results are encouraging. If the system proves reliable in the long term it may have important applications in the delivery of power to implanted artificial organs.
Risk Associated With Preoperative Anemia in Cardiac Surgery
Authors: Keyvan Karkouti, Duminda N. Wijeysundera, W. Scott Beattie
Journal: Circulation (2008)

Background— Preoperative anemia is an important risk factor for perioperative red blood cell transfusions, which are associated with postoperative morbidity and mortality. Whether preoperative anemia also is an independent risk factor for adverse outcomes after cardiac surgery, however, has not been fully elucidated. Methods and Results— In this multicenter cohort study, data were collected on 3500 consecutive patients who underwent cardiac surgery during 2004 at 7 academic hospitals. The prevalence of preoperative anemia, defined as hemoglobin &lt;12.5 g/dL, and its unadjusted and adjusted relationships with the composite outcome of in-hospital death, stroke, or acute kidney injury were obtained. The overall prevalence of preoperative anemia was 26%, with values ranging from 22% to 30% at the participating hospitals. After the exclusion of patients who had severe preoperative anemia (hemoglobin &lt;9.5 g/dL) or preoperative kidney failure and those who underwent emergency surgery, the composite outcome was observed in 7.5% of patients (247 of 3286). The unadjusted odds ratio for the composite outcome in anemic versus nonanemic patients was 3.6 (95% confidence interval, 2.7 to 4.7). The risk-adjusted odds ratios, obtained by multivariable logistic regression and propensity-score matching to control for important confounders (including comorbidities, institution, surgical factors, and blood transfusion), were 2.0 (95% confidence interval, 1.4 to 2.8) and 1.8 (95% confidence interval, 1.2 to 2.7), respectively. Conclusions— Preoperative anemia is independently associated with adverse outcomes after cardiac surgery. Future studies should determine whether therapies aimed at treating preoperative anemia would improve the outcomes of patients undergoing cardiac surgery.
Estimation of forearm arterial compliance in normal and hypertensive men from simultaneous pressure and flow measurements in the brachial artery, using a pulsed Doppler device and a first-order arterial model during diastole
Authors: A C. SIMON, S LAURENT, J A LEVENSON, J E BOUTHIER, M E SAFAR
Journal: Cardiovascular Research (1983)

Simultaneous brachial artery pressure and blood flow measurements were made in 45 men. Blood flow was evaluated by means of a pulsed Doppler device with a double transducer probe. From analysis of the pressure-flow curves during diastole, forearm arterial compliance (FAC) was determined by using the model of the forearm arterial tree as a system of tubes, each with a storage capacitance, in series with the arteriolar resistances vessels. The value of FAC for seven normal subjects, aged 44±3 (mean±SEM) years, was between 0.78 and 1.73·10−10·m−5·N−1. By comparison, a 30% reduction in FAC was observed in 38 men of the same age with essential hypertension, which was similar whether the intra-arterial diastolic pressure was above or below 90 mmHg. In the more severe group (Intra arterial diastolic pressure >90 mmHg), the reduced FAC was associated with a significant increase in brachial artery diameter; after administration of dihydralazine, blood pressure and arterial diameter returned to normal but FAC remained diminished. The study is the first to evaluate FAC in intact men. The reduced FAC in hypertension is independent of blood pressure "per se" but may reflect adaptive change in the walls of the large arteries. In the more severe hypertension, arterial calibre was increased; this could be a mechanism which could prevent FAC from decreasing further with chronic elevation of blood pressure.
Early deaths in Jamaican children with sickle cell disease.
Authors: D W Rogers, J M Clarke, L Cupidore, A M Ramlal, B R Sparke, G R Serjeant
Journal: BMJ (1978)

In Jamaican children with homozygous sickle cell (SS) disease diagnosed at birth two-year survival was 87%, compared with 95% in children with sickle cell-haemoglobin C (CS) disease, and 99% in normal controls. Death among those with SS disease occurred most often between the ages of 6 and 12 months. Principal causes were acute splenic sequestration and pneumococcal infection. Neonatal diagnosis of haemoglobinopathies must be followed by close observation if mortality is to be reduced by early diagnosis and treatment of these complications.
Boston As A Medical Center
Authors: HENRY A. CHRISTIAN
Journal: Annals of Internal Medicine (1929)

Article1 February 1929Boston As A Medical CenterHENRY A. CHRISTIAN, M.D.HENRY A. CHRISTIAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-8-861 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe student of medicine who comes to Boston finds himself with access to modern, well equipped hospitals and medical laboratories. There is a wealth of clinical material, freely accessible to graduate and undergraduate medical students. Three excellent medical schools offer a large variety of medical courses. A splendid medical library hospitably invites the reader to use its fine collection of medical books.In Boston, a city rich with traditions of able men and significant events, medicine, too, has its honored traditions. Here was established in 1782 one of the earliest American medical schools, from its inception an integral part of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1929Volume 2, Issue 8Page: 861-874KeywordsGraduate medical educationHospital medicineLibrariesUndergraduates Issue Published: 1 February 1929 PDF DownloadLoading ...