tbuckley/cabot-search huggingface dataset:
Medical Care at Winter Olympic Games
Authors: Bruno Haid
Journal: JAMA (1972)

Offering medical care at the Winter Olympics is a responsibility for the national organizing committee and is also a medicalmoral obligation. The potential problems connected with providing medical care are created primarily by the selection of the country and secondly of the region, town, or city in and around which the Winter Olympic Games are to be held. Thus, there are several different situations concerning the sites of the games which influence the type of medical care that could be offered. <h3>Sample Sites</h3><h3>Regional Site.—</h3> The first site to be considered is the quite newly developed area like Squaw Valley (1960 Olympics) that is remote from a bigger town or city. Here an adequate medical center or several stations or both types of facilities have to be built in various places, including all the facilities necessary to care for and treat the active competitors and their coaches and trainers, the
COMPARISON OF MID-TERM OUTCOMES OF CAROTID ARTERY STENTING FOR MODERATE VERSUS CRITICAL STENOSIS
Authors: Josef Veselka, Petra Zimolova, Lucie Martinkovicova, Miloslav Spacek, Judita Debreova, Petr Hajek, Martin Maly, David Zemanek, David Tesar, Pavol Tomasov
Journal: Journal of the American College of Cardiology (2011)
Effect on Hepatic Morphology of Treatment of Obesity by Fasting, Reducing Diets and Small-Bowel Bypass
Authors: Ernst J. Drenick, Fred Simmons, John F. Murphy
Journal: New England Journal of Medicine (1970)

Liver biopsies in 41 grossly obese subjects were evaluated during massive weight reduction (more than 100 lb). The subjects comprised three groups who had been treated by prolonged fasting, low-calorie dieting and intestinal bypass surgery. The first two groups manifested a transient increase in the degree of hepatocellular degeneration and focal necrosis along with progressive diminution of fatty infiltration during acute weight loss. Late follow-up biopsies revealed histologically normal livers. In contrast, bypass surgery was followed, variously, by massive fatty changes, cholestasis, polynuclear inflammatory infiltrates, diffuse fibrosis, bile-duct proliferation and fatal hepatic necrosis. Morphologic changes occurred while liver-function tests were still within normal limits. Follow-up biopsy examinations are the only reliable means of judging whether a bypass procedure is causing progressive parenchymal damage.
Special report adds nothing new, say paper authors
Authors: R G Carpenter, A Waite, R C Coombs, C Daman-Willems, A McKenzie, J Huber
Journal: BMJ (2007)

We were disappointed that Gornall's article1 was published without a response from us. It added nothing new.2 3 Our paper reviewed the first 57 deaths on the CONI (Care Of Next Infant), programme. We reaffirm that nine deaths were inevitable (recognised cause), and of the 48 unexpected deaths, seven were probable homicide. 

Professor Emery led the CONI …
Carriage of Corynebacterium acnes in school children in relation to age and race
Authors: MUNA MATTA
Journal: British Journal of Dermatology (1974)

The prevalence of Corynebacterium acnes on the foreheads of male and female children of caucasoid and negroid origin has been investigated using a semi-quantitative technique. Few organisms were recovered from children of less than 12 years of age. The increase in count occurred earliest in Negroid girls and latest in caucasoid boys. This may be related to the age of puberty.
Reciprocity between second-person neuroscience and cognitive robotics
Authors: Peter Ford Dominey
Journal: Behavioral and Brain Sciences (2013)

Abstract As there is “dark matter” in the neuroscience of individuals engaged in dynamic interactions, similar dark matter is present in the domain of interaction between humans and cognitive robots. Progress in second-person neuroscience will contribute to the development of robotic cognitive systems, and such developed robotic systems will be used to test the validity of the underlying theories.
Norepinephrine metabolism in humans. Kinetic analysis and model.
Authors: O A Linares, J A Jacquez, L A Zech, M J Smith, J A Sanfield, L A Morrow, S G Rosen, J B Halter
Journal: Journal of Clinical Investigation (1987)

The present study was undertaken to quantify more precisely and to begin to address the problem of heterogeneity of the kinetics of distribution and metabolism of norepinephrine (NE) in humans, by using compartmental analysis. Steady-state NE specific activity in arterialized plasma during [3H]NE infusion and postinfusion plasma disappearance of [3H]NE were measured in eight healthy subjects in the supine and upright positions. Two exponentials were clearly identified in the plasma [3H]NE disappearance curves of each subject studied in the supine (r = 0.94-1.00, all P less than 0.01) and upright (r = 0.90-0.98, all P less than 0.01) positions. A two-compartment model was the minimal model necessary to simultaneously describe the kinetics of NE in the supine and upright positions. The NE input rate into the extravascular compartment 2, estimated with the minimal model, increased with upright posture (1.87 +/- 0.08 vs. 3.25 +/- 0.2 micrograms/min per m2, P less than 0.001). Upright posture was associated with a fall in the volume of distribution of NE in compartment 1 (7.5 +/- 0.6 vs. 4.7 +/- 0.3 liters, P less than 0.001), and as a result of that, there was a fall in the metabolic clearance rate of NE from compartment 1 (1.80 +/- 0.11 vs. 1.21 +/- 0.08 liters/min per m2, P less than 0.001). We conclude that a two-compartment model is the minimal model that can accurately describe the kinetics of distribution and metabolism of NE in humans.
Abstract 2763: Activity of dasatinib and potential escape mechanisms in diffuse intrinsic pontine glioma (DIPG) models.
Authors: Nathalene Truffaux, Ludivine Le Dret, Stephanie Puget, Gilles Vassal, Birgit Geoerger, Jacques Grill
Journal: Cancer Research (2013)

Abstract Background Diffuse intrinsic pontine glioma (DIPG) have a dismal prognosis and their biology is not yet well explored. Using an integrated molecular profiling approach we revealed PDGFRA gene amplification and mutations in the extracellular domain as a characteristic of the oligodendroglial subgroup in newly diagnosed pediatric DIPG. Therefore we explored the therapeutic potential of dasatinib, an inhibitor of the PDGFR, Src, and Ephrin tyrosine-kinases in newly developed DIPG models. Materials and Methods A unique panel of 12 DIPG cell lines has been established from fresh tumor material biopsies in newly diagnosed children with DIPG with a 100% success rate. Four were oligoastrocytomas Grade 2 and 3, five astrocytomas Grade 2, 1 GBM and 2 non further specified; two had a gain of the PDGFRA gene. Effects of dasatinib on proliferation, invasion and cytotoxicity in vitro were determined at concentrations of 0.001-1 μM using the Live-cell imaging assay of the IncuCyte system. Cell growth and cell invasion were monitored by confluence algorithm, and cytotoxicity was determined by loss of membrane integrity generating nuclear staining by a fluorescent live-cell imaging reagent. Tyrosine-kinase receptors (RTK) and downstream signaling expression was assessed by phospho-RTK array and Western blot analysis. Results Anti-proliferative effects of dasatinib were observed in all 6 cell lines tested with IC50s between 0.02-0.07 μM. This compared favorably with the sensitive adult glioma T98G cell line and the pediatric supratentorial glioma SF188 cell line (0.15 μM and 0.3 μM, respectively). Significant dose-dependent cytotoxic effects were observed in two DIPG cell lines (NEM145 and NEM 168) and anti-invasive effects were seen in all cells at 0.1 μM. The two most sensitive cell lines exhibited PDGFRA activation and their primary tumors had a gain of PDGFRA. While Src was activated in all cell lines, we noticed that the less sensitive cell lines had MET overexpression. Conclusion Primary DIPG cell lines are highly sensitive in vitro to dasatinib suggesting its exploration is children with DIPG. Sensitivity may be linked not exclusively to PDGFRA activation but also to Src activation. The role of MET activation in escape mechanisms is currently explored. Citation Format: Nathalene Truffaux, Ludivine Le Dret, Stephanie Puget, Gilles Vassal, Birgit Geoerger, Jacques Grill. Activity of dasatinib and potential escape mechanisms in diffuse intrinsic pontine glioma (DIPG) models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2763. doi:10.1158/1538-7445.AM2013-2763
APOMORPHINE AS AN ANTIDOTE TO STRYCHNINE POISONING
Authors: DAVID GOLD
Journal: JAMA (1933)

In the course of another study the observation was made that a combination of morphine and apomorphine in very small doses, which by themselves produced no appreciable depression, gave rise to an unusual degree of motor fatigue. Experiments were then planned to determine whether this action might prove useful in antagonizing the actions of strychnine, in view of the recent report by Haggard and Greenberg<sup>1</sup>that in dogs and rats convulsions are diminished and recovery occurs after the administration of more than the single fatal dose of strychnine when the animals are treated with apomorphine, and in view of Dr. Martin's report, quoted by these authors, indicating that similar results can be obtained in man. In preliminary experiments the combination of morphine and apomorphine in very small doses proved entirely ineffective against strychnine poisoning, and the plan was not pursued further, but in one experiment a very large dose
Avastin is as effective as Lucentis for wet AMD and could save NHS 84m a year, study shows
Authors: N. Hawkes
Journal: BMJ (2012)

New trial results have confirmed that bevacizumab (Avastin) and ranibizumab (Lucentis) perform very similarly in the treatment of wet age related macular degeneration.

Using bevacizumab, which is much cheaper but is unlicensed for the condition, could save the NHS £84m a year, say the British researchers responsible for one of the trials.

The new data come from the second year of the comparison of age related macular degeneration treatment trials (CATT) and the interim analysis of one year’s results from the inhibit VEGF in age related choroidal neovascularisation (IVAN) trial. Both were presented at the annual meeting of the Association for Research in Vision and Ophthalmology at Fort Lauderdale in Florida and published in Ophthalmology .1 2

The trials were designed to discover whether patients given ranibizumab could read five more letters (CATT) or 3.5 more letters (IVAN) on an opticians’ chart, or better, than patients given bevacizumab. In neither trial was this limit exceeded, showing that bevacizumab …
The Pathogenesis of Atherosclerosis — An Update
Authors: Russell Ross
Journal: New England Journal of Medicine (1986)

CARDIOVASCULAR disease remains the chief cause of death in the United States and Western Europe, and atherosclerosis, the principal cause of myocardial and cerebral infarction, accounts for the majority of these deaths.1 This review, like its predecessor,2 will not attempt to cover all literature on atherosclerosis. In a previous review of the pathogenesis of atherosclerosis,2 Glomset and I discussed various hypotheses of atherogenesis2 3 4 5 6 7 and emphasized the importance of intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of atherosclerosis. The response-to-injury hypothesis of atherogenesis2 3 4 5 6 proposes that "injury" to the endothelium is the initiating event in . . .
Patency of skeletonized versus pedicled internal thoracic artery in coronary bypass graft surgery: A systematic review, meta-analysis and meta-regression
Authors: Michel Pompeu Barros de Oliveira Sá, Paulo Ernando Ferraz, Rodrigo Renda Escobar, Eliobas Oliveira Nunes, Pablo Lustosa, Frederico Pires Vasconcelos, Ricardo Carvalho Lima
Journal: International Journal of Surgery (2014)
The Cytonuclear Dimension of Allopolyploid Evolution: An Example from Cotton Using Rubisco
Authors: L. Gong, A. Salmon, M.-J. Yoo, K. K. Grupp, Z. Wang, A. H. Paterson, J. F. Wendel
Journal: Molecular Biology and Evolution (2012)

During allopolyploid speciation, two divergent nuclear genomes merge, yet only one (usually the maternal) of the two sets of progenitor organellar genomes is maintained. Rubisco (1,5-bisphosphate carboxylase/oxygenase) is composed of nuclear-encoded small subunits (SSUs) and plastome-encoded large subunits (LSUs), providing an ideal system to explore the evolutionary process of cytonuclear accommodation. Here, we take initial steps in this direction, using Gossypium allopolyploids as our model. SSU copies from divergent (5–10 My) progenitor diploids (“A” and “D” genomes) were combined at the time of polyploid formation 1–2 Ma, with the LSU encoded by the maternal A-genome parent. LSU genes from A- and D-genome diploids and AD-genome allopolyploids were sequenced, revealing several nonsynonymous substitutions and suggesting the possibility of differential selection on the nuclear-encoded rbcS partner following allopolyploid formation. Sequence data for the rbcS gene family revealed nonreciprocal homoeologous recombination between A- and D-rbcS homoeologs in all polyploid species but not in a synthetic intergenomic F1 hybrid, demonstrating “gene conversion” during allopolyploid evolution. All progenitor rbcS genes are retained and expressed in the five extant allopolyploid species, but analysis of the leaf transcriptome showed that A-homoeologs are preferentially expressed in both the allopolyploid and hybrid, consistent with the maternal origin of rbcL. Although rbcS genes from both progenitor genomes are expressed, some appear to have experienced mutations that may represent cytonuclear coevolution.
Quarter of people with diabetes in England are undiagnosed
Authors: Susan Mayor
Journal: BMJ (2005)

Nearly one in every four people with diabetes are undiagnosed or do not have the condition noted in their medical records, a clinical audit of all healthcare sectors in England published this week has found.

The first year of the National Diabetes Audit collected information on more than 250 000 people in England for 2003-4, with data given by 20% of primary care trusts, including more than 1700 general practices, 47 hospital trusts, and 58 specialist paediatric units. It compared the number of people diagnosed and registered with …
Lichen myxedematosus in a patient with hepatocellular carcinoma
Authors: P-Y. Lo, T-Y. Tzung
Journal: British Journal of Dermatology (2000)

S ir, Lichen myxedematosus (LM), or papular mucinosis, is a rare disorder characterized by a cutaneous eruption consisting of waxy papules with extensive thickening and hardening of the skin involving the arms, face and, to a lesser extent, the trunk and lower extremities. The skin changes are due to the deposition of mucin and proliferation of fibroblasts in the dermis. The cause of LM is unknown but monoclonal paraproteinaemia of the IgG‐lambda type is commonly found. LM shows a fluctuating but progressive course and does not remit spontaneously. Treatment remains unsatisfactory and may be required for considerable cosmetic disturbance and morbidity. Here we report a case of LM with concurrent development of hepatocellular carcinoma (HCC), which subsided following tumour resection. A 50‐year‐old male, who was a hepatitis C virus (HCV) carrier and an alcoholic, suffered from asymptomatic firm nodules of the lateral part of the eyebrows with diminished hair growth for 3 months, then multiple, grouped confluent skin‐coloured to erythematous papules and plaques appeared over the scalp, nape of the neck, upper back and anterior chest ( Fig. 1a). Similar lesions over the hands, with numbness, were also found. Biopsies from the scalp, eyebrow and left hand showed fragmentation and separation of collagen bundles with mucin deposition throughout the upper dermis confirmed by alcian blue at pH 2·5 (Fig. 1c). Large stellate elongated fibroblasts were present within the mucinous stroma. A series of examinations revealed elevated serum α‐fetoprotein level at 43·03 ng mL−1 (normal range < 10), abnormal liver function test (AST 69 U L−1 ALT 86 U L−1), polyclonal gammopathy, carpal tunnel syndrome, and hypertension. Abdominal computed tomography demonstrated a 1·5‐cm contrast‐enhanced tumour in segment 8 of the liver. Segmentectomy of the liver was performed and pathology revealed grade III HCC of trabecular type. Therefore LM associated with HCC was diagnosed. The numbness of his hands was relieved shortly after the surgical intervention. The polyclonal gammopathy did not significantly alter (IgG 2800 mg dL−1 before surgery and 2250 mg dL−1 six months later; normal range 735–1770 mg dL−1). The patient was observed for 7 months. Progressive improvement of the skin lesions with regrowth of the eyebrows was noted without further treatment (Fig. 1b).
Shortened bleeding time in acute myocardial infarction and its relation to platelet mass.
Authors: P C Milner, J F Martin
Journal: BMJ (1985)

The bleeding time, using the Simplate method, horizontal incision, and venostasis, was measured in a study of 51 patients admitted to a coronary care unit within 12 hours of the onset of chest pain. The bleeding time was significantly shorter in the 28 patients who were found to have definite myocardial infarction compared with the 23 others with chest pain but no definite infarction (p less than 0.0005). A bleeding time of less than 212 seconds correctly classified 84% of patients (sensitivity for definite myocardial infarction 89%) presenting to the coronary care unit with chest pain. Multiple regression analysis showed the bleeding time in all patients to be determined independently (and with high significance) by the following variables in order of importance: diagnostic group, platelet mass (platelet count X mean volume), and age. Packed cell volume was not a significant determinant. In the group with definite myocardial infarction considered alone the same order of variables was observed in predicting bleeding time, but none of them was significant. A major variable reducing bleeding time in acute myocardial infarction remains to be determined. There was no association between bleeding time and creatine phosphokinase activity or infarct size in the group with definite myocardial infarction.
In vitro preparation of infarcted myocardium.
Authors: B I Sasyniuk
Journal: Environmental Health Perspectives (1978)

An isolated ventricular endocardial preparation removed from canine hearts one to two days after coronary artery occlusion and superfused in vitro is described. The alteration in electrophysiological characteristics of subendocardial Purkinje fibers surviving in infarcted regions and the relationship of these changes to the generation of ventricular arrhythmias is discussed. The advantages of such preparations for assessing the mechanism of action of antiarrhythmic drugs in post-infarction ventricular arrhythmias is discussed.
TCT-31 Clinical Benefit of Radial Versus Femoral Approach in Percutaneous Coronary Intervention with Intra-Aortic Balloon Pump Support
Authors: Enrico Romagnoli, Maria De Vita, Francesco Burzotta, Francesco Summaria, Roberto Patrizi, Alessandro Sciahbasi, Valerio Lucci, Gianluca Pendenza, Caterina Cavazza, Niccoli Giampaolo, Leone Antonio Maria, Trani Carlo, Giuseppe Biondi-Zoccai, Fabio Tarantino, Ernesto Lioy, Crea Filippo, Giuseppe Sangiorgi
Journal: Journal of the American College of Cardiology (2012)
Discordant Imaging of a Thyroglossal Duct Cyst
Authors: STEPHEN N. WIENER, MONIQUE ANIEL-FRESON, SAUL M. GENUTH
Journal: Clinical Nuclear Medicine (1981)

WIENER, STEPHEN N. M.D.; ANIEL-FRESON, MONIQUE M.D.; GENUTH, SAUL M. M.D. Author Information
Fluoroquinolones in chronic obstructive pulmonary disease
Authors: A Colville, M Knowles, D Large, J George, P Mustchin
Journal: BMJ (1994)

Organisation's projections suggest that 1 in every 1000 people in India will be infected by 2000.2An Indian news magazine recently highlighted the problem of cross border trafficking by prostitutes from Nepal.' Commercial sex is an important route of transmission of HIV in Asian countries.At the heart of this problem is the complacency shown by the central government in New Delhi.It is astonishing that, while the numbers of cases of HIV infection and AIDS are rising, the programme budget remains underspent.'There is no coherent national strategy on conducting safe sex campaigns.Government departments shy away from giving explicit information about the spread of HIV.Campaigns through leaflets will have no role in rural areas owing to low literacy rates.But it is not too late to reverse the rising number of cases.Satellite television is now reaching the most remote parts of India.Both the government and voluntary organisations should be keen on using this in their fight against HIV infection and AIDS.
Electrophysiologic and clinical implications of induced or not ventricular fibrillation by programmed ventricular stimulation in patients with catecholaminergic polymorphic ventricular tachyarrhythmias
Authors: Fernando E. Cruz, Angelo A. de Paola, Marcio L. Fagundes, Bernardo Tura, Robert M. Sá, Carlo Napolitano, Silvia H. Boghossian, JoséCarlos B. Ribeiro, Lutgarde M. Vanheusden, Ivan G. Maia, Rafaela Bloise, Silvia G. Priori
Journal: Journal of the American College of Cardiology (2003)
LAW AND MEDICINE
Authors: Edwin J. Holman
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thionamides for Hyperthyroidism: On a Clear Day You Can Treat Forever
Authors: Albert M. Thomason
Journal: JAMA (1979)

The article by Slingerland and Burrows in this issue ofThe Journal(p 2408) results in two important conclusions: (1) if hyperthyroid patients are treated with thionamides (thioamides) for a sufficiently long time, few of them will have recurrence after discontinuation of the drug therapy, and (2) the adverse effects of long-term thionamide treatment do not occur with greater frequency than with short-term therapy (although the incidence of adverse effects in this series is comparatively low). If the use of thionamides is satisfactory, then why has it been supplanted by radioactive iodine as the primary method of treatment of hyperthyroidism? The answer lies in the relative advantages and disadvantages of both modalities. Certainly, social and economic factors are in part responsible; the mobility of our population makes it likely that the patient will not see the same physician for a period of years, encouraging the selection of the more expedient