Lupus Nephritis After Total Lymphoid Irradiation: Persistent Improvement and Reduction of Steroid Therapy
Authors: SAMUEL STROBER
Journal: Annals of Internal Medicine (1987)

Brief Reports1 November 1987Lupus Nephritis After Total Lymphoid Irradiation: Persistent Improvement and Reduction of Steroid TherapySAMUEL STROBER, M.D., M. CARMEN FARINAS, M.D., Ph.D., ELIZABETH H. FIELD, M.D., JOSE J. SOLOVERA, M.D., BRYCE A. KIBERD, M.D., BRYAN D. MYERS, M.D., RICHARD T. HOPPE, M.D.SAMUEL STROBER, M.D., M. CARMEN FARINAS, M.D., Ph.D., ELIZABETH H. FIELD, M.D., JOSE J. SOLOVERA, M.D., BRYCE A. KIBERD, M.D., BRYAN D. MYERS, M.D., RICHARD T. HOPPE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-5-689 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a previous study (1), we treated 10 patients with diffuse lupus nephritis, a moderate to high chronicity index on the renal biopsy, and nephrotic syndrome with total lymphoid irradiation as an alternative to cytotoxic drug therapy (2-7). Before total lymphoid irradiation, lupus renal disease activity was not controlled after 3 months of prednisone (0.5 mg/kg body weight · d or greater) alone or in combination with azathioprine, or recurred when the prednisone dosage was tapered below 0.5 mg/kg body weight · d (1). This report extends the follow-up of the 10 patients with lupus nephritis up to 6 years,...References1. STROBERFIELDHOPPE SER. Treatment of intractable lupus nephritis with total lymphoid irradiation. Ann Intern Med. 1985;102:450-8. LinkGoogle Scholar2. CADESPOONERSCHLEIN RGG. Comparison of azathioprine, prednisone, and heparin alone or combined in treating lupus nephritis. Nephron. 1973;10:37-56. CrossrefMedlineGoogle Scholar3. DONADIOHOLLEYWAGONERFERGUSONMCDUFFIE JKRRF. Further observation on the treatment of lupus nephritis with prednisone and combined prednisone and azathioprine. Arthritis Rheum. 1974;17:573-81. CrossrefMedlineGoogle Scholar4. HAHNKANTOROSTERLAND BOC. Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus: report of a prospective controlled trial in 24 patients. Ann Intern Med. 1975;83:597-605. LinkGoogle Scholar5. DONADIOHOLLEYFERGUSONILSTRUP JKRD. Treatment of diffuse proliferative lupus nephritis with prednisone and combined prednisone and cyclophosphamide. N Engl J Med. 1978;299:1151-5. CrossrefMedlineGoogle Scholar6. CARETTEKLIPPELDECKER SJJ. Controlled studies of oral immunosuppressive drugs in lupus nephritis: a long-term follow-up. Ann Intern Med. 1983;99:1-8. LinkGoogle Scholar7. AUSTINKLIPPELBALOW HJJ. Therapy of lupus nephritis: controlled trial of prednisone and cytotoxic drugs. N Engl J Med. 1986;314:614-9. CrossrefMedlineGoogle Scholar8. COHENREYNOLDSFRANKLIN AWE. Preliminary criteria for the classification of systemic lupus erythematosus. Bull Rheum Dis. 1971;21:643-8. Google Scholar9. BALOWAUSTINMUENZ JHL. Effect of treatment on the evolution of renal abnormalities in lupus nephritis. N Engl J Med. 1984;311:491-5. CrossrefMedlineGoogle Scholar10. BEN-CHETRITGROSSBRAVERMAN EDA. Total lymphoid irradiation in refractory systemic lupus erythematosus. Ann Intern Med. 1986;105:58-60. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Stanford University School of Medicine Stanford, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySpecialized Treatment Approaches and Niche Therapies for Lupus SubsetsUNPROVEN AND EXPERIMENTAL THERAPIESImmunosuppression, Lupus Nephritis, Multiple Sclerosis, and Organ TransplantationLong-term followup of patients treated with total lymphoid irradiation for lupus nephritisRenal Involvement in Systemic Lupus Erythematosus: A Study of 180 Patients from a Single CenterRôle de la radiothérapie dans les affections bénignesThe treatment of severe lupus nephritisLupus nephritis in childhood and adolescenceLUPUS NEPHRITISIMMUNOSUPPRESSIVE DRUG THERAPY OF SYSTEMIC LUPUS ERYTHEMATOSUSTHE COURSE AND TREATMENT OF LUPUS NEPHRITISImmune Ablation with Stem-Cell Rescue: A Possible Cure for Systemic Lupus Erythematosus?Total Lymphoid Irradiation in Multiple SclerosisSystemic Lupus Erythematosus and Related SyndromesKidney disease in systemic lupus erythematosusTherapeutic Trials in Lupus NephritisNéphropathies lupiquesIrradiation for xenogeneic transplantationImmunosuppression, Lupus Nephritis, Multiple Sclerosis, and Organ TransplantationImmunologic Aspects of Renal DiseaseLupus Nephritis: Pathogenesis, Course and ManagementThe treatment of lupus nephritisCellular Mechanisms in Immune Tolerance and Treatment of Autoimmune Disease: Studies Using Total Lymphoid Irradiation (TLI)Changes in b lymphocyte function in rheumatoid arthritis and lupus nephritis after total lymphoid irradiationCellular mechanisms in immune tolerance and treatment of autoimmune disease: Studies using total lymphoid irradiation (TLI)TreatmentTreatment of glomerulonephritis in systemic disease 1 November 1987Volume 107, Issue 5Page: 689-690KeywordsArthritisBiopsyBody weightDrug therapyFellowshipsImmunologyLupus nephritisRenal diseasesSteroid therapy Issue Published: 1 November 1987 PDF DownloadLoading ...