tbuckley/cabot-search huggingface dataset:
Allergic Reactions to Diphtheria, Tetanus, and Acellular Pertussis Vaccines Among Children with Milk Allergy
Authors: J.D. Kattan, A.L. Cox, A. Nowak-Wegrzyn, G. Gimenez, L. Bardina, H.A. Sampson, S.H. Sicherer
Journal: Journal of Allergy and Clinical Immunology (2011)
Dwelling Disparities: How Poor Housing Leads to Poor Health
Authors: Ernie Hood
Journal: Environmental Health Perspectives (2005)

In recent years, environmental health science has broadened the scope of its inquiries, expanding its investigations beyond the effects of single pollutants on individuals to incorporate the entire panorama of external factors that may affect people’s health. Consideration of the health impacts of the built environment—the human-modified places where we live, work, play, shop, and more—has been a key element in the ongoing evolution of the field of environmental health.
Sex differences among recipients of benzodiazepines.
Authors: H Habraken, K Soenen
Journal: BMJ (1993)

normal.Haemoglobin concentration was 85 g/l and the erythrocyte sedimentation rate was 30 mm in the first hour.Serum concentrations of electro- lytes, including calcium, were within normal limits, and angiotensin converting enzyme activity was normal.Results of tests for complement component (C3, C4), antinuclear antibodies, rheumatoid factor, antineutrophil cytoplasm anti- bodies, and paraprotein were negative.A tuber- culin test also yielded negative results.Other investigations showed the presence of a malabsorption syndrome with steatorrhea.A jejunal biopsy specimen showed a pattern typical of Whipple's disease with the presence in the mucosa of numerous macrophages that were positive on periodic acid Schiff and Gram staining.Renal biopsy showed tubulointerstitial nephritis with many granulomatous formations; there was diffuse infiltration of interstitial cells and fibrosis with tubular degeneration.There was no central caseation, and no acid fast bacilli were seen on Ziehl-Neelsen staining.Immunofluorescence yielded unremarkable findings.Treatment with doxycycline was started.His diarrhoea resolved and his weight increased concurrently.His renal impairment, however, remained stable.Although Whipple's disease is a systemic con- dition that can cause granulomas in other organs, only one previous case of well documented granu- lomatous interstitial nephritis has been reported.2We believe that we ruled out other causes of granulomatous interstitial nephritis in our patient and that a link between the nephropathy and Whipple's disease is probable.Crohn's disease and Whipple's disease should probably be added to the list of aetiologic factors in granulomatous inter- stitial nephritis already cited.
Facial and extrafacial eosinophilic pustular folliculitis: a clinical and histopathological comparative study
Authors: W.J. Lee, K.H. Won, C.H. Won, S.E. Chang, J.H. Choi, K.C. Moon, M.W. Lee
Journal: British Journal of Dermatology (2013)

Journal Article Facial and extrafacial eosinophilic pustular folliculitis: a clinical and histopathological comparative study Get access W.J. Lee, W.J. Lee Department of Dermatology Asan Medical Center University of Ulsan College of Medicine 388‐1 Pungnapdong Songpagu Seoul 138‐736 Korea Correspondence Mi Woo Lee. E‐mail: jijulee@hanmail.net Search for other works by this author on: Oxford Academic Google Scholar K.H. Won, K.H. Won Department of Dermatology Asan Medical Center University of Ulsan College of Medicine 388‐1 Pungnapdong Songpagu Seoul 138‐736 Korea Search for other works by this author on: Oxford Academic Google Scholar C.H. Won, C.H. Won Department of Dermatology Asan Medical Center University of Ulsan College of Medicine 388‐1 Pungnapdong Songpagu Seoul 138‐736 Korea Search for other works by this author on: Oxford Academic Google Scholar S.E. Chang, S.E. Chang Department of Dermatology Asan Medical Center University of Ulsan College of Medicine 388‐1 Pungnapdong Songpagu Seoul 138‐736 Korea Search for other works by this author on: Oxford Academic Google Scholar J.H. Choi, J.H. Choi Department of Dermatology Asan Medical Center University of Ulsan College of Medicine 388‐1 Pungnapdong Songpagu Seoul 138‐736 Korea Search for other works by this author on: Oxford Academic Google Scholar K.C. Moon, K.C. Moon Department of Dermatology Asan Medical Center University of Ulsan College of Medicine 388‐1 Pungnapdong Songpagu Seoul 138‐736 Korea Search for other works by this author on: Oxford Academic Google Scholar M.W. Lee M.W. Lee Department of Dermatology Asan Medical Center University of Ulsan College of Medicine 388‐1 Pungnapdong Songpagu Seoul 138‐736 Korea Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 5, 1 May 2014, Pages 1173–1176, https://doi.org/10.1111/bjd.12755 Published: 01 May 2014
Renalase deficiency aggravates ischemic myocardial damage
Authors: Yanling Wu, Jianchao Xu, Heino Velazquez, Peili Wang, Guoyong Li, Dinggang Liu, Benedita Sampaio-Maia, Janete Quelhas-Santos, Kerry Russell, Raymond Russell, Richard A. Flavell, Manuel Pestana, Frank Giordano, Gary V. Desir
Journal: Kidney International (2010)
How Do They Conduct 'N-HANES,' Anyway?
Authors: Charles Marwick
Journal: JAMA (1990)

WORKING in a space barely large enough to hold a couch, ultrasonographic equipment, and a videorecorder, technician Cynthia Runco, diagnostic sonographer, is visualizing another gallbladder, one of 10 she is doing this morning.  Runco is working on the National Health and Nutrition Examination Survey (usually pronounced N-HANES), one of the major projects of the CDC's National Center for Health Statistics.  This is the third such survey of the nation's health. The first was during the years 1971 through 1975 and the second, from 1976 through 1980.  The present survey began in 1988. It is scheduled to continue until 1994 and is expected to cost more than $100 million.  Runco and her associates, including a physician and a dentist, do health measurements, interviews, and laboratory tests out of a set of four mobile trailers. When their task is finished, the staff will have examined approximately 30 000 people in 88 communities.
Psueodomonas infections ofte fot olowing puncture wounds
Authors: P. H. Joanson
Journal: JAMA (1968)

Subacute infections of cartilaginous areas of the foot following puncture wounds in 11 children have persisted in spite of the administration of large doses of many different antibiotics. After an average of three weeks' delay, the failure of the treatment was explained by culture of<i>Pseudomonas aeruginosa</i>. Following appropriate surgical care, the infection has apparently been eliminated in all cases, but most of the children have significant residual skeletal damage. Prior reference to this condition has not been found in the medical literature.
More on Rotavirus Vaccination and Intussusception
Authors: Trudy V. Murphy, Paul M. Gargiullo, Melinda Wharton
Journal: New England Journal of Medicine (2002)

To the Editor: The results of the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study (Aug.16 issue) 1 suggest that the addition of clopidogrel to aspirin is beneficial for patients who have acute coronary syndromes without elevation of the ST segment.The inclusion criteria were changed after the first 3000 patients had been recruited.This change in the entry criteria during the course of recruitment means that the analysis of the results could be interpreted as a meta-analysis of two separate studies, rather than a single study.If one takes this view, the findings necessarily carry less weight.The investigators found the beneficial outcome of clopidogrel by considering two primary outcomes that were a composite of death from cardiovascular causes and various measures of morbidity.No benefit with respect to the risk of death was demonstrated, although the investigators noted that the study was not powered for this purpose.The use of clopidogrel was associated with a significant risk of major bleeding, and it would seem reasonable to include the rate of major bleeding in the measures of morbidity.Thus, if one defines a third primary outcome to be a composite of death from any cause, nonfatal myocardial infarction, stroke, refractory ischemia, and major bleeding, the relative risk of the outcome in the clopidogrel group, as compared with the placebo group, is 0.94 (95 percent confidence interval, 0.88 to 1.00; P>0.05).The use of this measure of efficacy makes the findings somewhat less convincing, especially if one considers the study to be a meta-analysis.
Health System Reform: Still Twitching
Authors: Joseph C. Rush
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Dr Schiff and colleagues<sup>1</sup>are correct in that perhaps an 8% to 10% addition on our income tax rates would bring sufficient financing for national health care of basic universal coverage. This would be in addition to a coinsurance factor on outpatient services of anywhere from 15% to 30% based on annual income as well, and with inpatient services having a 5% to 15% coinsurance factor, without deductible. After folding Medicaid, Medicare, and the Veterans Affairs hospitals into this system, the total take will approach $800 billion. The federal government should collect the money as a payroll tax and take it off budget and dole it out to the states based on population and age with the states administering the program. We cannot expect to get more out of the system than we put into it. Some fine-tuning in terms of adjustable rates for the coinsurance
Mycotic Aneurysms of the Intrapulmonary Arteries
Authors: SHIRLEY L. KAUFFMAN, JOSHUA LYNFIELD, GORDON R. HENNIGAR
Journal: Circulation (1967)

In the case presented, multiple aneurysms of the peripheral pulmonary arteries occurred in a child with secondary pulmonary hypertension complicated by bacterial endocarditis. Study of other reported cases suggests that pulmonary hypertension may be significantly associated with the development of mycotic aneurysms. As surgical resection of aneurysms has been at least temporarily successful, increased attention may be given to control of infection in these patients and to the appreciation of the frequency of aneurysms of the main pulmonary artery as well as peripheral pulmonary arteries in patients with congenital heart disease and pulmonary hypertension complicated by bacterial endocarditis.
<i>Serratia marcescens</i>Bacteremia Traced to an Infused Narcotic
Authors: Belinda E. Ostrowsky, Cynthia Whitener, Helen K. Bredenberg, Loretta A. Carson, Stacey Holt, Lori Hutwagner, Matthew J. Arduino, William R. Jarvis
Journal: New England Journal of Medicine (2002)

From June 30, 1998, through March 21, 1999, several patients in the surgical intensive care unit of a hospital acquired Serratia marcescens bacteremia. We investigated this outbreak.A case was defined as the occurrence of S. marcescens bacteremia in any patient in the surgical intensive care unit during the period of the epidemic. To identify risk factors, we compared patients with S. marcescens bacteremia with randomly selected controls. Isolates from patients and from medications were evaluated by pulsed-field gel electrophoresis. The hair of one employee was tested for fentanyl.Twenty-six patients with S. marcescens bacteremia were identified; eight (31 percent) had polymicrobial bacteremia, and seven of these had Enterobacter cloacae and S. marcescens in the same culture. According to univariate analysis, patients with S. marcescens bacteremia stayed in the surgical intensive care unit longer than controls (13.5 vs. 4.0 days, P<0.001), were more likely to have received fentanyl in the surgical intensive care unit (odds ratio, 31; P<0.001), and were more likely to have been exposed to two particular respiratory therapists (odds ratios, 13.1 and 5.1; P<0.001 for both comparisons). In a multivariate analysis, receipt of fentanyl and exposure to the two respiratory therapists (adjusted odds ratio for one therapist, 6.7; P=0.002; adjusted odds ratio for the other therapist, 9.5; P=0.02) remained significant. One respiratory therapist had been reported for tampering with fentanyl; his hair sample tested positive for fentanyl. Cultures of fentanyl infusions from two case patients yielded S. marcescens and E. cloacae. The isolates from the case patients and from the fentanyl infusions had similar patterns on pulsed-field gel electrophoresis. After removal of the implicated respiratory therapist, no further cases occurred.An outbreak of S. marcescens and E. cloacae bacteremia in a surgical intensive care unit was traced to extrinsic contamination of the parenteral narcotic fentanyl by a health care worker. Our findings underscore the risk of complications in patients that is associated with illicit narcotic use by health care workers.
Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases
Authors: T. Nijsten, C.G. Colpaert, P.B. Vermeulen, A.L. Harris, E. Van Marck, J. Lambert
Journal: British Journal of Dermatology (2004)

Background Cyclooxygenase (COX)‐2 expression and tumour‐induced angiogenesis appear to be increased in squamous cell carcinoma (SCC) of the skin. In other cancers, COX‐2 is a pro‐angiogenic factor. The association between angiogenesis and COX‐2 has not been studied in skin cancer. Objectives To assess the onset of increased COX‐2 expression and angiogenesis in the multistage carcinogenesis of SCC as well as the correlation between those two parameters. Patients/methods We performed a retrospective paired immunohistochemical analysis of normal skin, actinic keratosis (AK), Bowen's disease (BD) and SCC among 35 individuals. Specimens were considered COX‐2 immunopositive when 5% or more of the tumour cells showed clear evidence of immunostaining. To quantify active angiogenesis, we used a Ki‐67–CD34 double‐labelling immunohistochemical stain and calculated the fraction of proliferating endothelial cells. The Chalkley method was used to determine the microvessel density. To detect hypoxia, a carboanhydrase IX immunostain was used. Results Compared with normal epidermis (0%), AK (31%), BD (22%) and SCC (40%) were significantly more likely to be COX‐2 immunopositive (P < 0·01). The fraction of proliferating endothelial cells and the Chalkley scores paralleled multistage carcinogenesis (P < 0·05 between different stages). COX‐2 immunopositivity was fairly correlated with hypoxia and higher proliferating endothelial cell fractions but not with Chalkley counts. Conclusions Induction of COX‐2 expression and angiogenesis are both early events in the development of SCC. In addition to ultraviolet light, hypoxia and COX‐2 may be involved in skin tumour angiogenesis.
GPs urgently need help in inner cities, says college
Authors: N Craft
Journal: BMJ (1994)

General practitioners working in inner cities need help in coping with deprivation and its implications for health, said the Royal College of General Practitioners last week. “Inner city general practitioners often work under difficult conditions, seeking to serve a needy population in poor premises with deficient resources and decreasing numbers of secondary beds available,” said the college's inner city task force.

The task force was set up in July 1991 to define the problems facing …
RADIOLOGICAL EXAMINATION IN ORGANIC DISEASES OF SMALL INTESTINE
Authors: Ross Golden
Journal: JAMA (1953)

Organic disease of the small intestine, as well as functional disorders, may be the source of abdominal symptoms. X-ray examinations, when properly conducted, have proved to be of great value in the detection of these conditions. Occasional statements in the medical literature indicate that this fact is not widely recognized.  The records of 199 patients of the Presbyterian Hospital in New York with verified organic disease of the jejunum and ileum were analyzed. In 168 of them information suitable for the studies described was found. The purpose of this paper is to review the incidence of certain physical characteristics of these diseases that may be demonstrable by x-ray examination and to investigate the ability of the x-ray method to disclose evidence of these lesions as shown by the records in this series of cases. No attempt was made to compare or correlate the data from this series with those of
High Serum Cortisol Levels in Exercise-Associated Amenorrhea
Authors: JU-HONG DING
Journal: Annals of Internal Medicine (1988)

Objective: To determine whether basal Cortisol levels are elevated in exercise-associated amenorrhea. Design: Survey, with hormone levels measured weekly for 1 month and patients followed clinically for 6 months. Setting: Volunteers were recruited through media advertisements and fliers. Participants: Ninety-two women were enrolled; 71 (77%) completed the study. Subjects were grouped by menstrual and activity histories reported by a self-administered questionnaire. After 6 months, final groups were assigned: amenorrhea athletes, 19; eumenorrheic athletes, 35; a transition group of amenorrheic athletes who had resumed menses after entering the study, 7; and normal cyclic nonathletes, 10. Interventions: Four weekly resting blood samples (0800 to 1000 hours) were obtained and measured for Cortisol, estradiol, progesterone, and prolactin levels. Lumbar bone mineral density was measured by dual-photon densitometry. Measurements and Main Results: Mean (±SE) Cortisol levels were higher in amenorrheic athletes (585±33 nmol/L) than in eumenorrheic athletes (411±14 nmol/L), transition athletes (378±33 nmol/L), or nonathletic women (397±30 nmol/L) (P <0.01). Of nine women with abnormally high Cortisol levels (greater than 579 nmol/L), eight were amenorrheic athletes, and one was a eumenorrheic athlete. Bone mineral density was lower in amenorrheic athletes than in the other three groups (P <0.01). Conclusions: Increased glucocorticoid levels may be an etiologic factor in exercise-associated amenorrhea. High Cortisol levels could also contribute to decreased bone density. The failure of amenorrheic athletes with hypercortisolemia to regain menses within 6 months suggests that they are at risk for a prolonged acyclic state.
Alfred Stengel Memorial Lecture: The Therapeutic Role of Corticotropin and the Adrenal Steroids in Inflammatory Disease of the Digestive Tract.
Authors: W. L. Palmer
Journal: Annals of Internal Medicine (1963)

s1 April 1963Alfred Stengel Memorial Lecture: The Therapeutic Role of Corticotropin and the Adrenal Steroids in Inflammatory Disease of the Digestive Tract.W. L. Palmer, M.D., M.A.C.P.W. L. Palmer, M.D., M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-727_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn North America, although probably not in many other areas of the world, the most common chronic inflammatory diseases of bowel are ulcerative colitis, regional enteritis, and so-called ileocolitis. Whether these conditions be entities or related disorders is not yet established. The drugs producing the most dramatic influence upon their course are corticotropin and the adrenal steroids. As so often happens, these most effective agents are also the most dangerous. The intent of this presentation is to delineate further the indications for their use and the results to be expected, together with the limitations and hazards of therapy and the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Ill. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 727-727KeywordsAdrenocorticotropic hormoneDrugsEnteritisGastrointestinal tractInflammatory bowel diseaseSteroidsUlcerative colitis Issue Published: 1 April 1963 PDF DownloadLoading ...
Clinicians' forensic interpretations of fatal gunshot wounds often miss the mark
Authors: T. Randall
Journal: JAMA (1993)

ABSTRACT THE ODDS that a trauma specialist will correctly interpret certain fatal gunshot wounds are no better than the flip of a coin, according to a recent study at a level 1 trauma center. The study, which looked at single, perforating (exiting) gunshot wounds and multiple gunshot wounds, found that trauma specialists made errors in 52% of the cases, either in differentiating the entrance and exit wound, or in determining the number of bullets that struck the victim.Investigators at the Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, compared the postmortem findings of a board-certified forensic pathologist with the medical records of emergency medicine physicians, trauma surgeons, and neurosurgeons. The study is the first to quantify the forensic acumen of these specialists, says Vincent DiMaio, MD, a forensic pathologist and editor of The American Journal of Forensic Medicine and Pathology.The study's coauthors, Kim Collins, MD, a fourth-year
Declaration of Medical Writing Assistance in International Peer-Reviewed Publications
Authors: Karen L. Woolley, Julie A. Ely, Mark J. Woolley, Leigh Findlay, Felicity A. Lynch, Yoonah Choi, Jane M. McDonald
Journal: JAMA (2006)

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