tbuckley/cabot-search huggingface dataset:
Abstract LB-104: Prostate-specific inactivation of Atbf1 causes mouse prostatic intraepithelial neoplasia
Authors: Xiaodong Sun, Xiaoying Fu, Jie Li, Changsheng Xing, Henry F. Frierson, Robert D. Cardiff, Hao Wu, Jin-Tang Dong
Journal: Cancer Research (2012)

Abstract Cancer initiation and progression is triggered by loss of function of tumor suppressor genes. Previously, we have identified the AT-motif Binding Factor 1 (ATBF1) as a candidate tumor suppressor gene at 16q22 in the prostate. It undergoes frequent somatic mutations, reduced expression, or mislocalization in human cancers. However, its tumor suppressor role has not been examined in vivo. In the current study, we generated a conditional Atbf1 knockout mouse line using the Cre-loxP system. Tissue-specific inactivation of Atbf1 in prostatic epithelial cells caused hyperplasia in the dorsal lobes at as early as 4 months of age, which further progressed to mouse prostatic intraepithelial neoplasia (mPIN) in all four lobes. These precancerous lesions harbored molecular aspects similar to human PIN and prostate cancer, including increased cell proliferation, attenuated the basal cell layer, loss of the cell junction protein E-cadherin, and loss of an intact smooth muscle layer. Meanwhile, we observed elevated levels of Muc1 and p-Erk 1/2 in mPIN lesions. In addition, we identified and validated a number of genes that were disregulated in the Atbf1 knockout mice, and many of those genes encode secretory proteins. Supportively, an altered secretory protein profile was observed in the dorsal lobes. Taken together, our data demonstrated that loss of Atbf1 caused precancerous lesions in the prostate, thus providing in vivo evidence to a tumor suppressor role of the ATBF1 gene. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-104. doi:1538-7445.AM2012-LB-104
CELLULITIS SUCCEEDING CONTUSION OF LEG—EXTENSIVE SLOUGHING—SKIN GRAFTING—RECOVERY.
Authors: HENRY W. SAWTELLE
Journal: JAMA (1900)

This lesion occurred in a seaman, aged 24, native of Denmark, who was admitted to the U. S. Marine-Hospital, Chicago, August 22, 1899. The patient gave a history of having had chills and fever while serving in the Spanish-American war, and presented a malarial cachexia. The day before admission he was struck on the inner side of the left leg by a piece of lumber, producing a slight abrasion of the skin. The following night, and again the next day, he had a severe chill, followed by fever—39 C.—and intense headache. On examination, no bad effects were apparent, excepting a slight contusion at the point of injury; a continuous high temperature and accelerated pulse led to the suspicion of pus infection, which subsequently proved to be the case. The patient soon complained of pain, and the examination showed indications of the infective process. A free incision was made in the
THE QUANTIFICATION OF FUNCTIONAL CLASS AND THE SIX-MINUTE WALKING DISTANCE IN PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL SHUNTS: CLINICAL AND HEMODYNAMIC CORRELATES
Authors: Serdar Kucukoglu, Cihangir Kaymaz, Gul Sagin Saylam, Serdar Kula, Dursun Alehan, Atif Akcevin, Alpay Celiker, Sertac Cicek, Mehmet Gungor Kaya, Lale Tokgozoglu
Journal: Journal of the American College of Cardiology (2013)
Learning from low income countries: what are the lessons?: Community oral rehydration units can contain cholera epidemics
Authors: Walter H Curioso, J Jaime Miranda, Ann Marie Kimball
Journal: BMJ (2004)

<b>BACKGROUND AND PURPOSE:</b> It is difficult to differentiate the cause of brain abscesses with the use of CT and MR imaging. We did a comparative evaluation of pyogenic, tubercular, and fungal brain abscesses by using conventional, diffusion-weighted imaging (DWI), and proton MR spectroscopy (PMRS) with an aim to define the unique features that may differentiate among the pyogenic, tubercular, and fungal brain abscesses. <b>MATERIALS AND METHODS:</b> We performed a retrospective analysis on 110 patients with surgically proved brain abscesses. Imaging studies included T2, T1, postcontrast T1, DWI, and PMRS. Apparent diffusion coefficient (ADC) of the wall and cavity of the abscesses were quantified. The morphologic, physiologic, and metabolite features of pyogenic (<i>n</i> = 91), tubercular (<i>n</i> = 11), and fungal (<i>n</i> = 8) abscesses were compared. <b>RESULTS:</b> The pyogenic abscesses had smooth (55/91) and lobulated (36/91) walls, whereas the tubercular abscesses had smooth (4/11), lobulated (6/11), or crenated walls (1/11) with no intracavitary projections. The fungal abscesses showed irregular walls (lobulated 4/8, crenated 4/8) with intracavitary projections (8/8). The wall as well as the cavity showed low ADC in the pyogenic and tubercular abscesses. In the fungal abscesses, the wall and projections showed low ADC (8/8); however, the cavity itself showed high ADC (8/8). PMRS showed cytosolic amino acids (89/91), acetate (25/91), and succinate (18/91) in the pyogenic abscesses, whereas lipid/lactate (11/11) was seen in the tubercular abscesses. The fungal abscesses showed lipid (4/8), lactate (7/8), amino acids (4/8), and multiple peaks between 3.6 and 3.8 ppm assigned to trehalose (5/8). <b>CONCLUSION:</b> Based on the morphologic, ADC, and metabolite information, it may be possible to differentiate among the pyogenic, tubercular, and fungal brain abscesses.
Persistent vegetative state
Authors: P. Doherty
Journal: BMJ (1992)

unvalidated operational clinical criteria, including parkinsonian symptoms (S Williams et al, unpublished study).We suggest that sensitivity to neuroleptics in patients with dementia with cortical Lewy bodies is further evidence of the importance of the parkinsonian component of the condition and a reminder that the dosages in neuroleptic regimens for elderly people are largely determined empiric- ally.We advocate much lower doses of such drugs in routine psychogeriatric practice.
Reverse Crossed Cerebellar Diaschisis in Partial Complex Seizures Related to Herpes Simplex Encephalitis
Authors: CHAN H. PARK, SUNG M. KIM, LEOPOLD J. STRELETZ, JAMES ZHANG, CHARLES INTENZO
Journal: Clinical Nuclear Medicine (1992)

Tc-99m HMPAO brain SPECT was performed in a patient who had partial complex seizures for 1 year after successful acyclovir treatment of biopsy-proven herpes simplex encephalitis 2 years earlier. In spite of antiepileptic medications, her seizures were intractable and occurred daily. Tc-99m HMPAO was administered intravenously while she was having subclinical seizures, and brain SPECT demonstrated an area of hyperperfusion in the right temporal lobe medially and in the contralateral cerebellum. This reverse of the crossed cerebellar diaschisis phenomenon in epileptic disorders has not previously been documented.
A NEW VIRUS DISEASE OF PIGEONS
Authors: Joseph E. Smadel, E. B. Jackson, John W. Harman
Journal: The Journal of Experimental Medicine (1945)

A virus has been isolated from the tissues of a pigeon with visceral lesions that were characterized by focal necrosis of parenchymatous tissue, by the presence in affected cells of intranuclear inclusions of the herpetic type, and by secondary inflammatory reaction. This newly recognized virus, which has been tentatively called the I.N.I. agent is pathogenic for pigeons and embryonated eggs but is avirulent for rabbits, guinea pigs, and mice. The virus is smaller than the agent of psittacosis and is immunologically different from it. The I.N.I. agent and psittacosis virus were both of etiological importance in an epizootic among pigeons. Some birds were infected simultaneously with the two agents while others were infected with only one.
Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study
Authors: Junya Kanda, Hiroh Saji, Takahiro Fukuda, Takeshi Kobayashi, Koichi Miyamura, Tetsuya Eto, Mineo Kurokawa, Heiwa Kanamori, Takehiko Mori, Michihiro Hidaka, Koji Iwato, Takashi Yoshida, Hisashi Sakamaki, Junji Tanaka, Keisei Kawa, Yasuo Morishima, Ritsuro Suzuki, Yoshiko Atsuta, Yoshinobu Kanda
Journal: Blood (2011)
Motesanib Plus Carboplatin/Paclitaxel in Patients With Advanced Squamous Non–Small-Cell Lung Cancer: Results From the Randomized Controlled MONET1 Study
Authors: Silvia Novello, Giorgio V. Scagliotti, Oleksandr Sydorenko, Ihor Vynnychenko, Constantin Volovat, Claus-Peter Schneider, Fiona Blackhall, Sheryl McCoy, Yong-jiang Hei, David R. Spigel
Journal: Journal of Thoracic Oncology (2014)
DIOXYANTHRANOL 1-8 AS A SUBSTITUTE FOR CHRYSAROBIN
Authors: HERMAN BEERMAN
Journal: JAMA (1935)

The chemical compound dioxyanthranol 1-8 differs in its structural formula from chrysarobin by the lack of the methyl group. It is formed by reduction from dioxyanthraquinone 1-8, a substance used in industry. Dioxyanthranol 1-8, under the trade name Cignolin, was introduced into dermatology in 1916 as a substitute for chrysarobin by Galewsky 1 and Unna. 2 The latter carried through elaborate studies of its action on normal and diseased epidermis and showed that the elimination of the methyl group was responsible for the superior activity of the drug, that the 1-8 position of the hydroxyl groups in both chrysarobin and dioxyanthranol is responsible for the antisporiatic effect, and that the latter is approximately from two to five times as effective as the former on the same patient. Apparently, owing to manufacturing difficulties, it was withdrawn from the market in 1924 over the protest of Grumach 3 and Hauck, 4 but
Neuronal nitric oxide synthase gene polymorphism and IgE‐mediated allergy in the Central European population
Authors: L. I. Hollá, M. Schüller, D. Bučková, J. Vácha
Journal: Allergy (2004)

Background: Several findings suggest that nitric oxide (NO) plays a significant role in the regulation of the Th1/Th2 balance and contributes to the development of allergic diseases. Our study investigates a possible association of C/T transition located 276‐bp downstream from the translation termination site in exon 29 of the human nitric oxide synthase type 1 ( NOS1 ) gene with immunoglobulin E (IgE)‐mediated allergic diseases in the Czech population. Methods: The study included 688 subjects – 368 patients with clinically manifested allergic diseases and 320 unrelated controls with negative familial history of asthma/atopy. The NOS1 genotypes were determined by polymerase chain reaction (PCR) and restriction analysis by Eco 72I. Results: No significant differences were found for allele or genotype frequencies of the 5266 C/T polymorphism in exon 29 of the NOS1 gene between IgE‐mediated allergic diseases (or asthma alone) and healthy subjects. However, this common polymorphism showed a significant association with signs of atopy, especially with total serum IgE levels [log e IgE levels (mean ± SD): CC genotype = 4.34 ± 1.40; CT genotype = 4.58 ± 1.53; TT genotype = 5.01 ± 1.61; P &lt; 0.05). Conclusions: Our findings suggest that NOS1 gene may participate in the pathogenesis of high total serum IgE levels in allergic diseases in our population. These findings provide support for NOS1 as a candidate gene for IgE‐mediated allergy.
Impaired Infarct Healing in Atherosclerotic Mice With Ly-6ChiMonocytosis
Authors: Peter Panizzi, Filip K. Swirski, Jose-Luiz Figueiredo, Peter Waterman, David E. Sosnovik, Elena Aikawa, Peter Libby, Mikael Pittet, Ralph Weissleder, Matthias Nahrendorf
Journal: Journal of the American College of Cardiology (2010)
Bile Acid Sulfonates Alter Cholesterol Gallstone Incidence in Hamsters
Authors: Bertram I. Cohen, Shigeo Miki, Erwin H. Mosbach, Nariman Ayyad, Richard J. Stenger, Takahiro Mikami, Michiko Yoshii, Kenji Kihira, Takahiko Hoshita
Journal: Hepatology (1993)

The prevention of cholesterol gallstone formation by three bile acid analogs, sodium 3 alpha,7 alpha-dihydroxy-5 beta-cholane-24- sulfonate, sodium 3 alpha,7 beta-dihydroxy-5 beta-cholane-24-sulfonate and sodium 3 alpha,6 alpha-dihydroxy-5 beta-cholane-24-sulfonate, was examined in a hamster model of cholesterol cholelithiasis. Sodium taurochenodeoxycholate, sodium tauroursodeoxycholate and sodium taurohyodeoxycholate were studied simultaneously for comparison. Gallstones and cholesterol crystals were induced in 14 of 15 hamsters fed a bile acid-free, semipurified lithogenic diet containing 0.3% cholesterol and 4% butterfat for 6 wk. The addition of 0.1% sodium taurochenodeoxycholate and sodium tauroursodeoxycholate to the lithogenic diet had little effect on the formation of gallstones or biliary cholesterol crystals. In contrast, sodium 3 alpha,7 alpha-hydroxy-5 beta-cholane-24- sulfonate and sodium 3 alpha,7 beta-dihydroxy-5 beta-cholane-24-sulfonate, when fed at the same dose, prevented cholesterol gallstone formation significantly. Sodium taurohyodeoxycholate and sodium 3 alpha,6 alpha-dihydroxy-5 beta-cholane- 24-sulfonate inhibited cholesterol gallstone formation effectively. The cholesterol saturation index of bile was greater than 1.00 in all groups, with the exception of the group fed sodium 3 alpha,7 alpha-dihydroxy-5 beta-cholane-24-sulfonate. Liver and serum cholesterol levels tended to be lower in most of the groups that were fed bile acids. This effect was most pronounced in the animals receiving sodium taurohyodeoxycholate. At the end of the experiment, the administered sulfonate analogs were detected in gallbladder bile.(ABSTRACT TRUNCATED AT 250 WORDS)
Microbiology of the Eye
Authors: Albert M. Potts
Journal: JAMA (1973)

Of the 20 chapters of this text, eight are contributed by the senior authors and the remaining 12 by others who range in experience from the Harkness Professor of Ophthalmology at Columbia University to an Assistant Resident in Ophthalmology at the University Hospital. Books on ocular microbiology are not plentiful and an authoritative contribution like the present one is most welcome. One would feel even happier with the result if the book were more finely attuned to the realities of ocular microbiology in the 1970s. Chapters 16 through 19, which deal with viral infections of the eye, serve present needs admirably. However, rather than a no-decision chapter on the flora of the healthy eye and the scholarly chapter on inhibitory properties of ocular flora, present-day realities call for a section on antibacterial drugs and their interaction with microorganisms. Such a chapter is not present. The section on the cytology of
A new syndrome with pigmentation, scleroderma, gynaecomastia, Raynaud's phenomenon and peripheral neuropath
Authors: E.M. SAIHAN, J.L. BURTON, K.W. HEATON
Journal: British Journal of Dermatology (1978)

A middle‐aged man developed impotence, gynaccomastia, peripheral neuropathy, pigmentation lymphadenopathy, scleroderma, malabsorption and Raynaud's phenomenon following prolongec exposure to trichlorethylene. Some, but not all, of these features have previously been reported in vinyl chloride disease, and trichlorethlene is related chemically to vinyl chloride. Seven patients with a similar but not identical syndrome have been described in Japan and U.S.A., apparently unrelated to exposure to industrial toxins.
Expression of CD 21, CD 22, and the mouse erythrocyte receptor on peripheral B lymphocytes in rheumatoid arthritis.
Authors: S Hildebrandt, I von der Heydt, P von Wichert
Journal: Annals of the Rheumatic Diseases (1988)

The expression of the B cell antigens, CD 21, CD 22, and the mouse erythrocyte receptor (MER), on peripheral mononuclear cells (PMC) in 61 patients with rheumatoid arthritis (RA) and in 25 patients with various other forms of rheumatic disease was studied. Patients with RA showed significantly more peripheral B cells than control patients, whereas there was no difference between patients with RA and controls in resting B cells expressing the MER or resting and activated B cells expressing CD 21. Patients with active RA had significantly less MER positive and more CD 21 positive B cells than patients with inactive disease. The relation between disease activity and expression of MER and CD 21 was independent of drug treatment or production of classical rheumatoid factor. These data may be interpreted as a sign of B cell activation in RA. In addition, patients with seronegative RA receiving gold treatment showed significantly more MER positive cells than patients receiving different drugs, whereas patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) alone had significantly more CD 21 positive cells. This may be the result of different immunomodulating effects of drugs on B cell subsets.
Florida jury finds tobacco companies guilty of fraud
Authors: F. Charatan
Journal: BMJ (1999)

A six member jury in Miami has found that the seven largest American tobacco companies were guilty of fraud, misrepresentation, and conspiracy to conceal the addictiveness and dangers of cigarette smoking.

The jury also found that smoking cigarettes caused 19 diseases, including coronary heart disease, chronic obstructive pulmonary disease, and cancers of the lung, oropharynx, larynx, oesophagus, stomach, bladder, kidney, and cervix.

The jury, comprising three smokers and three non-smokers, held the tobacco companies liable for compensatory and punitive damages …
Use of cell proliferation data in modeling urinary bladder carcinogenesis.
Authors: S M Cohen, L B Ellwein
Journal: Environmental Health Perspectives (1993)

A multistage, probabilistic, biologically based model of carcinogenesis has been developed involving qualitative and quantitative aspects of the process. A chemical can affect the risk of cancer by directly damaging DNA and/or increasing the number of cell divisions during which errors in DNA replication can occur. Based on this model, carcinogens are classified as genotoxic versus nongenotoxic; nongenotoxic chemicals are further divided on the basis of whether or not they act through a specific cell receptor. Nongenotoxic compounds, particularly those acting through a nonreceptor mechanism, are likely to have dose and/or species-specific thresholds. This classification also implies the existence of chemicals that will be carcinogenic at high doses in animal models, but because of dose and/or mechanistic considerations, will not be carcinogenic to humans at levels of exposure. N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) and 2-acetylaminofluorene (AAF) are classical genotoxic bladder carcinogens that also cause proliferative effects at higher doses. Although there is an apparent no-effect level for the urinary bladder carcinogenicity of these two compounds at low doses, in reality, DNA adducts form at these low levels, and it is likely that there is a cancer effect (no threshold), but it is below the level of detection of the bioassay. These conclusions are based on studies involving multiple doses and time points in rodents, including results from the ED01. Pellets implanted directly into the rodent bladder lumen or calculi formed in the urine as a result of an administered chemical cause abrasion of the urothelium, and a marked increase in cell proliferation and cell number, and ultimately tumors.(ABSTRACT TRUNCATED AT 250 WORDS)
Screening for Chronic Kidney Disease: U.S. Preventive Services Task Force Recommendation Statement
Authors: Virginia A. Moyer
Journal: Annals of Internal Medicine (2012)

Chinese translation Description: New U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for chronic kidney disease (CKD). Methods: The USPSTF reviewed evidence on screening for CKD, including evidence on screening, accuracy of screening, early treatment, and harms of screening and early treatment. Population: This recommendation applies to asymptomatic adults without diagnosed CKD. Testing for and monitoring CKD for the purpose of chronic disease management (including testing and monitoring patients with diabetes or hypertension) are not covered by this recommendation. Recommendation: The USPSTF concludes that the evidence is insufficient to assess the balance of benefits and harms of routine screening for CKD in asymptomatic adults (I statement).
Interleukin-1 receptor antagonist plasma concentration is specifically increased by alpha-2A-interferon treatment
Authors: Sylvie Naveau, Dominique Emilie, Eric Borotto, Alain Portier, Yasmina Lazizi, Vincent Giraud, Liliane Grangeot-Keros, Frédérique Capron, Pierre Galanaud, Jean-Claude Chaput
Journal: Journal of Hepatology (1997)
A direct immunofluorescence study in elastosis perforans serpiginosa
Authors: R. BERGMAN, RACHEL FRIEDMAN-BIRNBAUM, B. HAZAZ
Journal: British Journal of Dermatology (1985)

Journal Article A direct immunofluorescence study in elastosis perforans serpiginosa Get access R. BERGMAN, R. BERGMAN Department of Dermatology, Rambam Medical Center and Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa Search for other works by this author on: Oxford Academic Google Scholar RACHEL FRIEDMAN‐BIRNBAUM, RACHEL FRIEDMAN‐BIRNBAUM Department of Dermatology, Rambam Medical Center and Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa Rachel Friedman‐Birnbaum, M.D., Head, Department of Dermatology, Rambam Medical Center, P.O. Box, 9602, Haifa 31096, Israel. Search for other works by this author on: Oxford Academic Google Scholar B. HAZAZ B. HAZAZ Clinical Laboratory, Beilinson Medical Center, Petah Tiqva, Israel Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue 5, 1 November 1985, Pages 573–579, https://doi.org/10.1111/j.1365-2133.1985.tb02381.x Published: 01 November 1985 Article history Accepted: 19 April 1985 Published: 01 November 1985
Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus.
Authors: C Meyer, M Stumvoll, V Nadkarni, J Dostou, A Mitrakou, J Gerich
Journal: Journal of Clinical Investigation (1998)

Release of glucose by liver and kidney are both increased in diabetic animals. Although the overall release of glucose into the circulation is increased in humans with diabetes, excessive release of glucose by either their liver or kidney has not as yet been demonstrated. The present experiments were therefore undertaken to assess the relative contributions of hepatic and renal glucose release to the excessive glucose release found in type 2 diabetes. Using a combination of isotopic and balance techniques to determine total systemic glucose release and renal glucose release in postabsorptive type 2 diabetic subjects and age-weight-matched nondiabetic volunteers, their hepatic glucose release was then calculated as the difference between total systemic glucose release and renal glucose release. Renal glucose release was increased nearly 300% in diabetic subjects (321+/-36 vs. 125+/-15 micromol/min, P < 0.001). Hepatic glucose release was increased approximately 30% (P = 0.03), but increments in hepatic and renal glucose release were comparable (2.60+/-0.70 vs. 2.21+/-0.32, micromol.kg-1.min-1, respectively, P = 0.26). Renal glucose uptake was markedly increased in diabetic subjects (353+/-48 vs. 103+/-10 micromol/min, P < 0.001), resulting in net renal glucose uptake in the diabetic subjects (92+/-50 micromol/ min) versus a net output in the nondiabetic subjects (21+/-14 micromol/min, P = 0.043). Renal glucose uptake was inversely correlated with renal FFA uptake (r = -0.51, P < 0.01), which was reduced by approximately 60% in diabetic subjects (10. 9+/-2.7 vs. 27.0+/-3.3 micromol/min, P < 0.002). We conclude that in type 2 diabetes, both liver and kidney contribute to glucose overproduction and that renal glucose uptake is markedly increased. The latter may suppress renal FFA uptake via a glucose-fatty acid cycle and explain the accumulation of glycogen commonly found in the diabetic kidney.