Peripheral Facial Nerve Palsy after High-Dose Radioiodine Therapy in Patients with Papillary Thyroid Carcinoma
Authors: David Levenson
Journal: Annals of Internal Medicine (1994)

Brief Reports1 April 1994Peripheral Facial Nerve Palsy after High-Dose Radioiodine Therapy in Patients with Papillary Thyroid CarcinomaDavid Levenson, MD, Seza Gulec, MD, Martin Sonenberg, MD, PhD, Eseng Lai, MD, PhD, Stanley J. Goldsmith, MD, and Steven M. Larson, MDDavid Levenson, MDFrom the Memorial Sloan-Kettering Cancer Center, New York, New York., Seza Gulec, MDFrom the Memorial Sloan-Kettering Cancer Center, New York, New York., Martin Sonenberg, MD, PhDFrom the Memorial Sloan-Kettering Cancer Center, New York, New York., Eseng Lai, MD, PhDFrom the Memorial Sloan-Kettering Cancer Center, New York, New York., Stanley J. Goldsmith, MDFrom the Memorial Sloan-Kettering Cancer Center, New York, New York., and Steven M. Larson, MDFrom the Memorial Sloan-Kettering Cancer Center, New York, New York.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-7-199404010-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Sialoadenitis is a frequent complication of radioiodine treatment, occurring clinically in 10% of patients [1], although biochemical alterations of saliva are present 100% of the time [2]. This is caused by the similar iodine avidity of the salivary gland and thyroid tissue, each achieving a tissue-to-serum ratio of approximately 50 [3]. Administration of thyroid-stimulating hormone can cause a tenfold increase in thyroid iodine uptake [4].May [5] listed 81 distinct causes of peripheral facial nerve palsies, including traumatic, infectious, and metabolic. Idiopathic Bell palsy accounted for 57% of the 1575 cases he himself reported. Peripheral facial nerve palsy is associated ...References1. Allweiss P, Braunstein GD, Katz A, Waxman A. Sialadenitis following I-131 therapy for thyroid carcinoma: concise communication. J Nucl Med. 1984; 25:755-8. Google Scholar2. Maier H, Bihl H. Effect of radioactive iodine therapy on parotid gland function. Acta Otollaryngol (Stockh). 1987; 103:318-24. Google Scholar3. Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text. 6th ed. Philadelphia: J.B. Lippincott; 1991:53. Google Scholar4. Wolff J, Halmi NS. Thyroidal iodine transport: V. The role of Na± K± activated, ouabain-sensitive adenosinetriphosphatase activity. J Biol Chem. 1963; 238; 847-51. Google Scholar5. May M. The Facial Nerve. New York: Thieme, Inc.; 1986:182-3. Google Scholar6. Andrews JC, Abemayor E, Alessi DM, Canalis RF. Parotitis and facial nerve dysfunction. Arch Otolaryngol Head Neck Surg. 1989; 115; 240-2. Google Scholar7. Loebinger R, Budinger TF, Watson EE; eds. MIRD Primer for Absorbed Dose Calculations. New York: Society of Nuclear Medicine; 1988. Google Scholar8. Earll JM, Kolb FO. Facial paralysis occurring with hypothyroidism. A report of two cases. Calif Med. 1967; 106; 56-8. Google Scholar9. Cox NH, Chew D, Williams JG, Morris AI. Bell's palsy associated with hypothyroidism. Br J Clin Pract. 1985; 39; 158-9. Google Scholar10. Lee TC, Harbert JC, Dejter SW, Mariner DR, VanDam J. Vocal cord paralysis following I-131 ablation of a postthyroidectomy remnant. J Nucl Med. 1985; 26; 49-50. Google Scholar Author, Article, and Disclosure InformationAffiliations: From the Memorial Sloan-Kettering Cancer Center, New York, New York.Corresponding Author: David Levenson, MD, Department of Medicine, Endocrinology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021-6094.Grant Support: By the Endocrine and Metabolic Research Training Program, National Institutes of Health grant DK07313. 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