tbuckley/cabot-search huggingface dataset:
A clinical study of left ventricular relaxation.
Authors: Y Hirota
Journal: Circulation (1980)

Left ventricular (LV) relaxation was studied in patients with hypertrophic cardiomyopathy (HCM, n =18), congestive cardiomyopathy (CCM, n = 11), hypertensive heart disease (HHD, n = 8), coronary artery disease (CAD) without left ventricular (LV) asynergy (n = 9) and with LV asynergy (n =17), mitral stenosis (MS, n = 16), and mitral regurgitation (MR, n = 8). The time constant T and peak negative dP/dt were used as indexes of LV relaxation, and 18 normal subjects served as controls. The time constant T was higher in elderly patients among normal contros (r = 0.652, p &lt; 0.01), which suggests that prolongation of relaxation is a phenomenon of aging. The normal value of the time constant T was 33 +/- 8 msec (mean +/- SD), and that of peak negative dp/dt was 1864 +/- 390 mm Hg/sec. The time constant T was significantly higher in HCM (64 +/- 20 msec), CCM (56 +/- 14 msec), CAD without asynergy (53 +/- 16 msec), CAD with asynergy (57 +/- 13 msec) and MS (47 +/- 12 msec). Peak negative dP/dt was significantly lower in HCM (998 +/- 303 mm Hg/sec), CCM (1060 +/- 334 mm Hg/sec), CAD with asynergy (1370 +/- 299 mm Hg/sec), MS (1367 +/- 313 mm Hg/sec) and MR (1139 +/- 305 mm Hg/sec). Although the genesis of LV relaxation abnormality is not clear from this investigation, it seems to have multiple causes. Relaxation abnormality seems to be one of the earliest manifestations of mechanical dysfunction of the human left ventricle.
698 IMPAIRED REGULATORY ABILITY AND PREDOMINANCE OF THE GAMMA-DELTA VDELTA1 SUBSET IN PATIENTS WITH HCV-RELATED TYPE 2 CRYOGLOBULINEMIA
Authors: S. Ferri, R. Menichella, C. Lalanne, M. Bassi, P. Muratori, F.B. Bianchi, L. Muratori, M. Lenzi
Journal: Journal of Hepatology (2010)
Marihuana in Adolescents
Authors: Doris H. Milman
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Drs. Kolansky and Moore are to be congratulated for their keenly observed and lucidly presented clinical description in "Effects of Marihuana on Adolescents and Young Adults" (<b>216</b>:486-492, 1971). Although they are not the first to record these observations, they certainly offer an impressively large series of patients whose symtoms can be ascribed to marihuana uncomplicated by other drugs. I have made the observation before, but I think it is worth restating, that the reason many physicians and, hence, the public are unaware of the adverse effects of marihuana is simply that they fail to make the association between the one and the other. Careful history taking is essential, but the association must first be thought of before the inquiry can be made. If the historian is the parent, he is often unaware that his child is using marihuana. If the informant is the patient, he may
How to do it. Organise an international medical meeting. I: Committees and budgets.
Authors: I Capperauld, A I Macpherson
Journal: BMJ (1978)

At some time in his professional career a doctor may be concerned with organising a medical meeting.Meetings range from large international ones to small local gatherings, but the principles for organising all of them are the same.The object of our six articles in this series is to state these principles, to expand on topics that are often alien to the medical mind, and to point out some of the pitfalls that may trap the unwary and uninitiated.The principles are simple, and some of the things we say will seem obvious, but the obvious is often overlooked merely because it is simple.In these articles we shall be discussing committees, budgets, scientific and social programmes, registra- tion, and other aspects of medical meetings.
Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.
Authors: S E Dorman, S M Holland
Journal: Journal of Clinical Investigation (1998)

IFN-gamma is critical in the immune response to mycobacterial infections, and deficits in IFN-gamma production and response have been associated with disseminated nontuberculous mycobacterial infections. Mutations in the IFN-gamma receptor ligand-binding chain (IFNgammaR1) have been shown to confer susceptibility to severe infection with nontuberculous mycobacteria. However, mutations in the IFN-gamma receptor signal-transducing chain (IFNgammaR2) have not been described. We describe a child with disseminated Mycobacterium fortuitum and M. avium complex infections and absent IFN-gamma signaling due to a mutation in the extracellular domain of IFNgammaR2. In vitro cytokine production by patient PBMCs showed 75% less PHA-induced IFN-gamma production than in normal cells, while patient PHA-induced TNF-alpha production was normal. The normal augmentation of TNF-alpha production when IFN-gamma was added to endotoxin was absent from patient cells. Expression of IFNgammaR1 was normal, but there was no phosphorylation of Stat1 in response to IFN-gamma stimulation. DNA sequence analysis of the gene for IFNgammaR2 showed a homozygous dinucleotide deletion at nucleotides 278 and 279, resulting in a premature stop codon in the protein extracellular domain. This novel gene defect associated with disseminated nontuberculous mycobacterial infection emphasizes the critical role that IFN-gamma plays in host defense against mycobacteria.
Estimating the prevalence of aero-allergy and/or food allergy in infants, children and young people with moderate-to-severe atopic eczema/dermatitis in primary care: multi-centre, cross-sectional study
Authors: Sangeeta Dhami, Aziz Sheikh
Journal: Journal of the Royal Society of Medicine (2015)

Objective We sought to determine the primary care-based prevalence of moderate-to-severe atopic eczema/dermatitis in children and to estimate what proportion had co-morbid aero-allergy and/or food allergy that was contributing to their atopic eczema/dermatitis. Design Multi-centre, cross-sectional study. Participants Infants, children and young people aged between 0–17 years. Setting Primary Care. Methods General practice electronic health records were interrogated to identify children (0–17 years) with current moderate-to-severe atopic eczema/dermatitis. Eligible children were assessed by an allergy specialist nurse, this involving a detailed allergy history, examination and, if appropriate, measurement of total IgE and specific IgE to relevant aero-allergens and/or food allergens. Main outcome measures Prevalence of atopic eczema, moderate to severe atopic eczema, IgE-mediated atopic eczema. Results We recruited eight practices, which together enrolled 16,877 children. Of these, 4331 (25.7%; 95% CI 25.0, 26.3) children had a recorded diagnosis of atopic eczema/dermatitis and 1316 (7.8%; 95% CI 7.4, 8.2) had treatment indicative of current moderate-to-severe atopic eczema/dermatitis. We recruited 159 children for clinical assessment, and complete data were available for 157. The clinical assessment revealed that 130/157 (82.8%) had no indication of IgE-mediated allergy contributing to their atopic eczema/dermatitis; the remaining 27/157 (17.2%; 95% CI 12.1, 23.9) were on clinical assessment considered to possibly have underlying IgE-mediated disease. Specific IgE tests were positive in 14/27 (51.9%; 95% CI 34.0, 69.3) children. Of the 14 children who tested positive, six (42.9%; 95% CI 21.4, 67.4) were positive to food allergens and six (42.9%; 95% CI 21.4, 67.4) to aero-allergens; the remaining two (14.3%; 95% CI 4.0, 40.0) were positive to both food and aero-allergens. Conclusions Although atopic eczema/dermatitis is a very common diagnosis in children in primary care, most appear to be relatively mild and/or transient. Only a small proportion of children had evidence of ongoing underlying IgE-mediated atopic eczema/dermatitis.
Walter Crawford Jamieson
Authors: J S. Jamieson
Journal: BMJ (2002)

gynaecologist Huddersfield Royal Infirmary (b Leeds 1916; q Leeds 1938;FRCS Ed, FRCOG), died from a heart attack on 2 July 2002. Arter qualifying and a year in general practice, he joined the Royal Air Force and was posted to Sri Lanka, where he remained throughout the second world war. On returning home in 1946 he did short periods in general practice followed by vari ous obstetric appointments, becoming a registrar at St James's Hospital, Leeds. He was appointed a consultant in obstetrics and gynaecology at the Huddersfield Royal Infirmary in 1959. An enthusiastic golfer, he loved travel, sports, music, and the theatre. After retirement he lived in West Cork in Ireland in a house purchased years ago as a retreat from the stresses of work. He leaves a wife, Nuala. [Nuala Denniss]
Method of using pressurized aerosols.
Authors: C K Connolly
Journal: BMJ (1975)

in July 1971, another (48) has not been seen since October 1967October , and three (8, 13, and 24) had emigrated in good health in 1968October , 1969October , and 1971, respectively., respectively.Eleven patients had died.The table shows the actual number of deaths compared with the expected number in 5-year age groups.Cerebrovascular disease probably caused death in four cases, and cardio- vascular disease in two.Two others died suddenly and unexpectedly while recovering from a severe painful crisis and the lack of causal pathology at necropsy was compatible with a cardiac arrhythmia.Forty two were traced during 1973, of whom 32 had regularly attended the clinic during the past five years, six had been specially contacted and examined for the present survey, and four (2, 22, 40, and 54) had not been seen but had corresponded or were reliably reported alive.Thirty three patients were in
Nosocomial outbreak of cryptosporidiosis in AIDS patients.
Authors: P Ravn, J D Lundgren, P Kjaeldgaard, W Holten-Anderson, N Hojlyng, J O Nielsen, J Gaub
Journal: BMJ (1991)

To describe a nosocomial outbreak of cryptosporidiosis during four months after June 1989.A department of infectious diseases in Copenhagen, seeing about half the patients with AIDS in Denmark.73 HIV antibody negative subjects and 60 antibody positive subjects admitted as inpatients during the transmission period of the outbreak (20 June-14 August), of whom 18 (17 with AIDS, one with AIDS related complex), developed cryptosporidiosis. Two further HIV negative subjects (one departmental secretary, one visiting relative) developed cryptosporidiosis.Cryptosporidia in stool samples, clinical symptoms, CD4 cell count, HIV antigen concentration, chemotherapeutic treatment.The source of the outbreak was identified as ice from an ice machine in the ward, contaminated by an incontinent, psychotic patient with cryptosporidiosis picking out ice for cold drinks. The mean incubation time was at least 13 days-that is, twice that in HIV-negative patients. Of the 18 patients with AIDS who developed cryptosporidiosis, five recovered, two were symptomless carriers, three died of unrelated causes, and eight died after prolonged diarrhoea. Among the 57 exposed HIV antibody positive inpatients (excluding two patients and the index case with cryptosporidiosis diagnosed elsewhere), significantly more of those who developed symptomatic cryptosporidiosis received oral sulphonamides than those who did not (91%, 10/11 v 48%, 21/44, p less than 0.05).The clinical and epidemiological findings indicate that infection was the consequence of very small inocula. Increased sensitivity to cryptosporidiosis may be an unrecognised side effect of oral sulphonamide treatment in patients with AIDS.
Foreword and Introduction
Authors: A.-E. Meyer, Waltraud Bolz
Journal: Psychotherapy and Psychosomatics (1981)

Other Types| February 16 2010 Foreword and Introduction Subject Area: Psychiatry and Psychology A.-E. Meyer; A.-E. Meyer Hamburg Search for other works by this author on: This Site PubMed Google Scholar Waltraud Bolz Waltraud Bolz Hamburg Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1981) 35 (2-3): 81–84. https://doi.org/10.1159/000287483 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation A.-E. Meyer, Waltraud Bolz; Foreword and Introduction. Psychother Psychosom 31 December 1981; 35 (2-3): 81–84. https://doi.org/10.1159/000287483 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1981Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
An overview of species differences in the effects of a water extract of cotton bract on isolated airway smooth muscle, and effects of E. coli lipopolysaccharide.
Authors: J S Fedan, V A Robinson, D W Hay, K C Weber
Journal: Environmental Health Perspectives (1986)

Our laboratory has been comparing the activity of a water extract of cotton bract (CBE) with the isolated trachealis smooth muscle of the dog, guinea pig, and cat. CBE induced contractions that were not mediated by 5-hydroxytryptamine (5-HT), histamine, or muscarinic receptors. The active agent(s) in CBE was dialyzable (less than 14,000 molecular weight), and substantial activity was retained after low-temperature ashing. CBE potentiated contractions of dog trachealis to histamine and 5-HT and relaxation responses to isoproterenol, whereas it had no effect on responses to methacholine and KCl. In the guinea pig trachealis, CBE reduced responsiveness to KCl, potentiated relaxations to adenosine and ATP, and did not alter the responses to the remaining agents. Responses of cat trachealis to KCl and isoproterenol were potentiated by CBE, while those to 5-HT were unaffected. Neurogenic cholinergic contractile responses were potentiated by CBE in the trachealis of the dog, but not of the guinea pig, while neurogenic relaxations were potentiated by CBE in guinea pig trachealis but not in the dog trachealis. There are thus marked species differences in the acute effects of CBE on airway smooth muscle. Due to recent interest in the possible involvement of bacterial endotoxins in the etiology of byssinosis, we examined the effects of E. coli lipopolysaccharide (LPS) in guinea pig trachealis. An initial examination revealed that LPS potentiated responses to histamine, but not those to methacholine and isoproterenol. This effect vanished upon a second appraisal with a different batch of LPS. The effect of LPS in airway smooth muscle is thus, at present, equivocal.
Ciliary defects in healthy subjects, bronchiectasis, and primary ciliary dyskinesia.
Authors: R U de Iongh, J Rutland
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

To develop criteria to aid in the diagnosis of primary ciliary dyskinesia (PCD) we analyzed quantitatively the incidence and the range of ciliary ultrastructural abnormalities in healthy subjects and in patients with respiratory tract disease. The beat frequency and ultrastructure of nasal respiratory tract cilia, including ciliary orientation, were measured in 62 healthy subjects (31 nonsmokers, 20 exsmokers, and 11 smokers), ranging in age from 1 to 76 yr, and in 51 patients with respiratory tract disease. In healthy subjects, ciliary beat frequency (CBF) ranged between 9.6 and 15.3 Hz, the incidence of microtubule defects varied between 0 to 9%, the mean number of inner dynein arms per cilium ranged from 3.0 to 7.1, and the mean number of outer dynein arms per cilium ranged from 7.4 to 9.0. The deviation of cilia in healthy subjects varied between 8 and 29 degrees. By comparing the data for ciliary defects in healthy subjects with the data obtained from patients with respiratory disease, we identified two patient groups: patients with PCD (n = 31) and patients with respiratory tract disease not due to PCD. For comparison with the PCD patients, a group of 20 patients with bronchiectasis was selected and analyzed. Patients with PCD had significantly lower CBF (p < 0.001), significantly higher incidences of peripheral and central tubule defects (p < 0.01), and greater ciliary disorientation (p < 0.005). There was a strong correlation between CBF and the number of outer dynein arm numbers, but not with inner dynein arm numbers, suggesting that inner and outer dynein arms may play different functional roles in producing ciliary motility.(ABSTRACT TRUNCATED AT 250 WORDS)
The Sensitivity and Specificity of a Simple Test To Distinguish between Urge and Stress Urinary Incontinence
Authors: Jeanette S. Brown, Catherine S. Bradley, Leslee L. Subak, Holly E. Richter, Stephen R. Kraus, Linda Brubaker, Feng Lin, Eric Vittinghoff, Deborah Grady
Journal: Annals of Internal Medicine (2006)

Background: Urinary incontinence is common in women. Because treatments differ, urge incontinence should be distinguished from stress incontinence. To make this distinction, current guidelines recommend an extensive evaluation that is too time-consuming for primary care practice. Objective: To test the accuracy of a simple questionnaire to categorize type of urinary incontinence in women. Design: Multicenter, prospective study of the accuracy of the 3 Incontinence Questions (3IQ) compared with an extended evaluation to distinguish between urge incontinence and stress incontinence. Setting: 5 academic medical centers in the United States. Participants: 301 women enrolled from April to December 2004 who were older than 40 years of age (mean age, 56 years [SD, 11]) with untreated incontinence for an average of 7 years (SD, 7) and a broad range of incontinence severity. Measurements: All participants included in the analyses answered the 3IQ questionnaire, and a urologist or urogynecologist who was blinded to the responses performed the extended evaluation. Sensitivity, specificity, and likelihood ratios were determined for the 3IQ. Results: For classification of urge incontinence and with the extended evaluation as the gold standard, the 3IQ had a sensitivity of 0.75 (95% CI, 0.68 to 0.81), a specificity of 0.77 (CI, 0.69 to 0.84), and a positive likelihood ratio of 3.29 (CI, 2.39 to 4.51). For classification of stress incontinence, the sensitivity was 0.86 (CI, 0.79 to 0.90), the specificity was 0.60 (CI, 0.51 to 0.68), and the positive likelihood ratio was 2.13 (CI, 1.71 to 2.66). Limitations: Participants were enrolled by urologists and urogynecologists at academic medical centers. Conclusions: The 3IQ questionnaire is a simple, quick, and noninvasive test with acceptable accuracy for classifying urge and stress incontinence and may be appropriate for use in primary care settings. Similar studies are needed in other populations. We also need a clinical trial comparing the outcomes of treatments based on the 3IQ and the extended evaluation.
Fat Embolism in Thoracic Operations
Authors: F. McKeown
Journal: BMJ (1955)

septicaemia, meningitis, pneumococcal infections, etc., may at times be associated with toxic haemoglobinuria as a result of an acute haemolytic crisis.One is struck by the dramatic onset of favism: it can result in the destruction of more than 75% of the red cells in the blood within 24 hours.However, the response to blood transfusion is nothing short of miraculous.Favism can recur, and the only prevention is to refrain from eating the broad-bean.
Is intestinal metaplasia of the stomach reversible?
Authors: M M Walker
Journal: Gut (2002)

Intestinal metaplasia (IM) of the stomach is a risk factor in developing intestinal-type gastric cancer and hence the question of reversibility is vital. There is emerging epidemiological evidence that with long term follow up, IM may be reversible although a combination of antioxidant agents and eradication of <i>H pylori</i> may be necessary to achieve this. The pathogenesis of IM is currently being elucidated and it is likely that a combination of bacterial, host, and environmental factors will be shown to lead to IM. In assessing gastric cancer risk, histochemical typing of IM will most probably be replaced by molecular markers.
Isolation of α-toxin-producing<i>Staphylococcus aureus</i>from the skin of highly sensitized adult patients with severe atopic dermatitis
Authors: K. Wichmann, W. Uter, J. Weiss, K. Breuer, A. Heratizadeh, U. Mai, T. Werfel
Journal: British Journal of Dermatology (2009)

Staphylococcus aureus (S. aureus) is a well-known trigger factor of atopic dermatitis (AD). Besides staphylococcal superantigens, alpha-toxin may influence cutaneous inflammation via induction of T-cell proliferation and cytokine secretion.To investigate the association between sensitization to inhalant allergens and skin colonization with alpha-toxin-producing S. aureus in AD.We investigated 127 patients with AD, aged 14-65 years, who were on standard anti-inflammatory and antiseptic treatment before investigation. We evaluated skin colonization, medical history, severity of AD and sensitization to inhalant allergens.Forty-eight of 127 patients were colonized with S. aureus, suffered from more severe AD, had asthma more often and showed higher sensitization levels to inhalant allergens. Thirty of 48 patients with S. aureus skin-colonizing strains produced alpha-toxin and had higher total IgE and specific IgE to birch pollen and timothy grass pollen.Under topical treatment with antiseptic and anti-inflammatory agents the colonization of lesional skin with S. aureus was clearly lower than commonly found in untreated patients with AD. Colonization with S. aureus was associated with a higher severity of AD, higher degree of sensitization, and a higher frequency of asthma. The proportion of patients whose skin was colonized with alpha-toxin-producing S. aureus was higher than expected from a former study. Cutaneous colonization with alpha-toxin-producing S. aureus was associated with a higher sensitization level to birch pollen allergen in AD. This may point to a higher susceptibility of patients with higher T-helper 2 polarization towards alpha-toxin-producing S. aureus.