Effects of Enalapril on Erythrocytosis after Renal Transplantation
Authors: Robert S. Gaston, Bruce A. Julian, Arnold G. Diethelm, John J. Curtis
Journal: Annals of Internal Medicine (1991)

Brief Reports15 December 1991Effects of Enalapril on Erythrocytosis after Renal TransplantationRobert S. Gaston, MD, Bruce A. Julian, MD, Arnold G. Diethelm, MD, John J. Curtis, MDRobert S. Gaston, MDSearch for more papers by this author, Bruce A. Julian, MDSearch for more papers by this author, Arnold G. Diethelm, MDSearch for more papers by this author, John J. Curtis, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-12-954 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptErythrocytosis afflicts 4% to 17% of renal allograft recipients. It appears most often within the first year after transplant, usually in patients with excellent graft function, and is associated with an increased risk for thromboembolic events (1). Although the pathophysiology is poorly defined, it may relate to excess production of erythropoietin by native kidneys (2). The standard therapy is serial phlebotomy (1), but no treatment has proved optimal. A recent report of enalapril-associated anemia in renal transplant recipients (3) led to a trial of this agent as therapy for post-transplant erythrocytosis.MethodsTwelve renal allograft recipients (mean age, 39 ±...References1. WickreNormanBennisonBarryBennett CDAJW. Postrenal transplant erythrocytosis: a review of 53 patients. Kidney Int. 1983;23:731-7. CrossrefMedlineGoogle Scholar2. AeberhardSchneiderVallottonKurtzLeski JPMAM. Multiple site estimates of erythropoietin and renin in polycythemic kidney transplant patients. Transplantation. 1990;50:613-6. CrossrefMedlineGoogle Scholar3. VlahakosCanzanelloMadaioMadias DVMN. Enalapril-associated anemia in renal transplant recipients treated for hypertension. Am J Kidney Dis. 1991;17:199-205. CrossrefMedlineGoogle Scholar4. Williams G. Converting-enzyme inhibitors in the treatment of hypertension. N Engl J Med. 1988;319:1517-24. CrossrefMedlineGoogle Scholar5. ThomasMarshallRoss-RussellWetherley-Meindu BoulayPearson DJRGGT. Effect of haematocrit on cerebral blood flow in man. Lancet. 1977;2:941-3. CrossrefMedlineGoogle Scholar6. FrimanNybergBlohme SGI. Erythrocytosis after renal transplantation; treatment by removal of the native kidneys. Nephrol Dial Transplant. 1990;5:969-73. CrossrefMedlineGoogle Scholar7. BakrisSauterHusseyFisherGaberWinsett GEJJAR. Effects of theophylline on erythropoietin production in normal subjects and in patients with erythrocytosis after renal transplantation. N Engl J Med. 1990;323:86-90. CrossrefMedlineGoogle Scholar8. GouldGoodmanDeWolfOnestiSwartz ASRGC. Interrelation of the renin system and erythropoietin in rats. J Lab Clin Med. 1980;96:523-34. MedlineGoogle Scholar9. JacksonFranzeSumithranJohnston BLEC. Pharmacologic nephrectomy with chronic angiotensin converting enzyme inhibitor treatment in renovascular hypertension in the rat. J Lab Clin Med. 1990;115:21-7. MedlineGoogle Scholar10. MurrayVenutoKohliCunningham BRRE. Enalapril-associated acute renal failure in renal transplants: possible role of cyclosporine. Am J Kidney Dis. 1990;16:66-9. CrossrefMedlineGoogle Scholar11. IslamBourbigotCodetSongyGournierCledes MBJBGJ. Captopril induces correction of post renal transplant erythremia. Transplant Int. 1990;3:222-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of Alabama Medical Center, Birmingham, Alabama. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPost-transplant erythrocytosis refractory to ACE inhibitors and angiotensin receptor blockersUrologische Malignome und rheumatoide ArthritisRenin–Angiotensin System Polymorphisms and Hemoglobin Level in Renal Allografts: A Comparative Study Between Losartan and EnalaprilTreatment of Erythrocytosis Associated with Obesity Hypoventilation SyndromeAnemia and COPDAngiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunctionTHE ANAEMIA OF SILENT DIABETIC NEPHROPATHY-PREVALENCE, PHYSIOPATHOLOGY, AND MANAGEMENTPosttransplant erythrocytosisPostrenal transplant erythrocytosis: risk factors and effectiveness of angiotensin receptor antagonistsRoutine renin-angiotensin system blockade in renal transplantation?Losartan may modulate erythropoietin productionCorrelation between carotid intima-media thickness and hematocrit and hemoglobin values in renal transplant recipientsAngiotensin II infusion increases plasma erythropoietin levels via an angiotensin II type 1 receptor-dependent pathwayLosartan Reduces Hematocrit in Patients with Chronic Obstructive Pulmonary Disease and Secondary ErythrocytosisDemetrios V. 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