Transformation of Hepatic Cell Adenoma to Hepatocellular Carcinoma Due to Oral Contraceptive Use
Authors: Edwin J. Gyorffy
Journal: Annals of Internal Medicine (1989)

Brief Reports15 March 1989Transformation of Hepatic Cell Adenoma to Hepatocellular Carcinoma Due to Oral Contraceptive UseEdwin J. Gyorffy, MD, James E. Bredfeldt, MD, William C. Black, MDEdwin J. Gyorffy, MDSearch for more papers by this author, James E. Bredfeldt, MDSearch for more papers by this author, William C. Black, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-6-489 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough there is a causal relation between the use of oral contraceptives and hepatic cell adenoma (1), a similar relation between the use of oral contraceptives and hepatocellular carcinoma remains speculative. Studies of hepatocellular carcinoma in young women using oral contraceptives and other epidemiologic evidence suggest a possible causal relation (2-5). A more fundamental question is whether hepatic cell adenomas are premalignant and can transform into hepato-cellular carcinoma. We report the case of a long-term user of oral contraceptives in whom a hepatic cell adenoma, as shown by a biopsy sample, transformed into hepatocellular carcinoma.Case ReportA 53-year-old white...References1. Klatskin G. Hepatic tumors: possible relationship to use of oral contraceptives. Gastroenterology. 1977;73:386-94. CrossrefMedlineGoogle Scholar2. GoodmanIshak ZK. Hepatocellular carcinoma in women: probable lack of etiologic association with oral contraceptive steroids. Hepatology. 1982;2:440-4. CrossrefMedlineGoogle Scholar3. HendersonPreston-MartinEdmondsonPetersPike BSHRM. Hepatocellular carcinoma and oral contraceptives. Br J Cancer. 1983;48:437-40). CrossrefMedlineGoogle Scholar4. FormanVincentDoll DTR. Cancer of the liver and use of oral contraceptives. Br Med J [Clin Res] 1986;292:1357-61. CrossrefMedlineGoogle Scholar5. FormanDollPeto DRR. Trends in mortality from carcinoma of the liver and the use of oral contraceptives. Br J Cancer. 1983;48:349-54. CrossrefMedlineGoogle Scholar6. GalaGriffin KT. Hepatomas in young women on oral contraceptives: report of two cases and review of the literature. J Surg Oncol. 1983;22:11-4. CrossrefMedlineGoogle Scholar7. NeurbergerFormanDollWilliams JDRR. Oral contraceptives and hepatocellular carcinoma. Br Med J [Clin Res] 1986;292:1355-7. CrossrefMedlineGoogle Scholar8. GordonReddyLivingstoneJeffersSchiff SKALE. Resolution of a contraceptive-steroid-induced hepatic adenoma with subsequent evolution into hepatocellular carcinoma. Ann Intern Med. 1986;105:547-9. LinkGoogle Scholar9. TeslukLawrie HJ. Hepatocellular adenoma: its transformation to carcinoma in a user of oral contraceptives. Arch Pathol Lab Med. 1981;105:296-9. MedlineGoogle Scholar10. EdmondsonReynoldsHendersonBenton HTBB. Regression of liver cell adenomas associated with oral contraceptives. Ann Intern Med. 1977;86:180-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Edwin J. Gyorffy, MD; James E. Bredfeldt, MD; William C. Black, MDAffiliations: From the University of New Mexico School of Medicine, Albuquerque, New Mexico. For current author addresses, see end of text. 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