tbuckley/cabot-search huggingface dataset:
Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT)
Authors: D Chihara, H Ito, T Matsuda, K Katanoda, A Shibata, S Taniguchi, A Utsunomiya, T Sobue, K Matsuo
Journal: Blood Cancer Journal (2013)

Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm with a very poor outcome. However, several studies have shown a progress in the treatment. To evaluate the effect of the progress in the treatment of ATLL in a whole patient population, we used vital statistics data and estimated age-adjusted mortality and trends in the mortality from 1995 to 2009. Since allogeneic hematopoietic stem-cell transplantation (allo-HSCT) has been introduced as a modality with curative potential during study period, we also evaluated the association of the annual number of allo-HSCT and the trend of the mortality of ATLL. Endemic (Kyushu) and non-endemic areas (others) were evaluated separately. Significance in the trend of mortality was evaluated by joinpoint regression analysis. During the study period, a total of 14 932 patients died of ATLL in Japan, and mortality decreased significantly in both areas (annual percent change (95% confidence interval (CI)): Kyushu, -3.1% (-4.3, -1.9); others, -3.4% (-5.3, -1.5)). This decreasing trend in mortality seems to be associated with an increase in the number of allo-HSCTs (Kyushu, R-squared=0.70, P=0.003; and others, R-squared=0.55, P=0.058). This study reveals that the mortality of ATLL is now significantly decreasing in Japan and this decreasing trend might be associated with allo-HSCT.
A Department of Medicine in 1963–1973
Authors: George W. Thorn
Journal: New England Journal of Medicine (1964)

The commemoration of the fiftieth anniversary of the founding of the Peter Bent Brigham Hospital provides a uniquely appropriate opportunity to discuss the plans of the Department of Medicine for the decade 1963–1973. At this point in time the Department is responsible for approximately 120 patient beds and includes a professional staff of approximately 100 full-time and part-time physicians, with 80 to 90 interns, residents and research fellows in training. The Department is responsible for approximately a fourth of the Harvard Medical School second-year, third-year and fourth-year teaching in medicine. We are fortunate indeed in having Harvard Medical School, with . . .
Air Pollution in Charleston, South Carolina
Authors: B. Dixon Holland
Journal: JAMA (1961)

This study of air pollution in Charleston, South Carolina, was undertaken at the request of the state health department and is intended primarily for the information and guidance of the state and local officials. Such studies have been made of several other cities and similar reports prepared. This report is well written, fully illustrated, and strengthened with easily understood tables, charts, graphs, drawings, photographs, and appendixes. For the enlightenment of interested lay, technical, and professional persons, private as well as public, everywhere, this report gives a clear exposition of the factors that may account for air pollution. It broadly outlines for the assessment and control of air pollution a program which, while tailored to Charleston, could be adapted to other communities. It enjoins a sane and sound approach to air pollution control. Inferentially, it deplores the approach taken by some communities in which the control efforts (many times ineffective) result
Here Is Farther Away Than There
Authors: Kristin Roedell
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of Rho-Kinase in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stents in Pigs In Vivo
Authors: Takashi Shiroto, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Jun Takahashi, Kenta Ito, Hatsue Ishibashi-Ueda, Hiroaki Shimokawa
Journal: Journal of the American College of Cardiology (2009)
Anti-elastin autoantibodies are not present in combined pulmonary fibrosis and emphysema
Authors: V. Cottin, N. Fabien, C. Khouatra, A. Moreira, J-F. Cordier
Journal: European Respiratory Journal (2008)

To the Editors: 

Whereas tobacco smoking is a well-established risk factor for the development and progression of chronic obstructive pulmonary disease (COPD), the molecular basis for individual predisposition and disease progression remains largely unknown. Immunological processes and especially autoreactive immune processes have recently been implicated, with anti-elastin antibodies and a T-helper type-1 lymphocyte response identified in patients with COPD/emphysema 1. Immune mechanisms are also implicated in interstitial lung disease and pulmonary fibrosis 2, and smoking-induced autoimmunity has been demonstrated in rheumatoid arthritis 3.

We explored whether an autoimmune process implicating anti-elastin autoantibodies and facilitated by tobacco smoking may take place in patients with combined pulmonary fibrosis and emphysema (CPFE), a distinct entity recently defined on the basis of characteristic features of chest imaging, pulmonary function and outcome 4.

Patients with CPFE, diagnosed within …
Deltex1 Redirects Lymphoid Progenitors to the B Cell Lineage by Antagonizing Notch1
Authors: David J Izon, Jon C Aster, Yiping He, Andrew Weng, Fredrick G Karnell, Vytas Patriub, Lanwei Xu, Sonia Bakkour, Carlos Rodriguez, David Allman, Warren S Pear
Journal: Immunity (2002)
The Origin of Aortic Phospholipid in Rabbit Atheromatosis
Authors: D. B. ZILVERSMIT, MORIS L. SHORE, R. F. ACKERMAN
Journal: Circulation (1954)

Radioactive phosphorus (P 32 ) was injected into normal and cholesterol-fed rabbits. A marked derangement of aortic phospholipid metabolism was found in the cholesterol-fed animals. The phospholipid found in the atheromatous aortas appeared to have been synthesized by the aorta itself rather than to have been deposited there from the plasma.
Concerning Therapeutic Abortion
Authors: Roy J. Heffernan
Journal: JAMA (1965)

<h3>To the Editor:—</h3> It was disturbing to read that "therapeutic abortions may be easier to obtain... than they were twenty years ago" (<i>JAMA</i><b>193,</b>July 5, 1965, adv p 45). Progress in the management of the complications of pregnancy has made so many other indications invalid it is difficult to understand why "psychogenic indications have increased from 13% of all abortions in 1943 to 87.5% in 1963." Many authorities have inveighed against interruption of pregnancy because of neuropsychiatric disease. Arbuse and Schechtman (<i>Amer Pract Dig Treat</i><b>1</b>:1069-1075 [Oct] 1950) in an excellent review state: "There does not seem to be any one condition which absolutely indicates interruption of pregnancy." Ebaugh and Heuser (<i>Postgrad Med J</i><b>2</b>:325-332 [Nov] 1947) are of the opinion that abortion may do far more harm than good to a person with a well-balanced nervous system and may cause considerable damage to a patient with
Evidence That Angiotensin II Is Present in Human Monocytes
Authors: Takanari Kitazono, Richard C. Padgett, Mark L. Armstrong, Pamela K. Tompkins, Donald D. Heistad
Journal: Circulation (1995)

The purpose of the present study was to determine whether human monocytes and polymorphonuclear leukocytes contain angiotensins I and II.Human mononuclear and polymorphonuclear leukocytes were isolated from blood. To identify angiotensins in human leukocytes, we performed immunocytochemistry using both alkaline phosphatase and fluorescence methods. With light microscopy immunocytochemistry with alkaline phosphatase, prominent staining of angiotensin II was observed in mononuclear leukocytes. Angiotensin I was also demonstrated in mononuclear leukocytes, but the signal was less pronounced than for angiotensin II. Polymorphonuclear leukocytes showed very little staining for angiotensin II. Fluorescence immunocytochemistry also demonstrated angiotensin II in mononuclear leukocytes. Angiotensins I and II in homogenate of leukocytes were quantified by radioimmunoassay. The concentration of angiotensins I and II in mononuclear leukocytes was 355 +/- 216 (mean +/- SEM) and 2331 +/- 106 fmol/mg protein, respectively, and the concentration in polymorphonuclear leukocytes was 36 +/- 10 and 336 +/- 120 fmol/mg protein.These findings suggest that human mononuclear leukocytes contain large amounts of angiotensin II and lesser amounts of angiotensin I. Human polymorphonuclear leukocytes contain small amounts of angiotensin I and II.
First transit and equilibrium radionuclide angiography in patients with inferior transmural myocardial infarction: Criteria for the diagnosis of associated hemodynamically significant right ventricular infarction
Authors: Mark R. Starling, Louis J. Dell’Italia, Tuhin K. Chaudhuri, Bruce L. Boros, Robert A. O’Rourke
Journal: Journal of the American College of Cardiology (1984)
Gastric Irradiation in Peptic Ulcer
Authors: Howard M. Spiro
Journal: JAMA (1974)

For almost half a century, the University of Chicago Clinic has been home to one of the grand centers of gastroenterology in the United States; and Walter L. Palmer, the editor of this book, has been one of the deans of American gastroenterology. His learned clinical and research studies illuminated the halls of that clinic. In 1937, Dr. Palmer and his colleagues began an intensive if uncontrolled study on how the course of peptic ulcer was affected by irradiation of the gastric fundus. A third of a century later, this monograph appears in an up-to-date tally sheet for this admittedly controversial therapy given to 2,200 peptic ulcer patients. For the physician who does not wish to wade through the details of ten chapters well written by his associates, Dr. Palmer has provided a 13-page summary of the apparent beneficial effects of irradiation. The editor and the authors take the position
CLINICAL RISK PROFILE DOES NOT PREDICT IMPLANTABLE DEFIBRILLATOR (ICD) INTERVENTION RATE IN AN UNSELECTED COHORT OF PATIENTS WITH CONGESTIVE HEART FAILURE
Authors: Rasmus Borgquist, Johanna Sjblom, Fredrik Gadler, Torbjrn Kalm, Lina Ljung, Viveka Frykman, Mrten Rosenqvist, Pyotr Platonov, Arrhythmia Clinic
Journal: Journal of the American College of Cardiology (2014)
Equipment for the Disabled. Outdoor Transport
Authors: C. J. Goodwill
Journal: Annals of the Rheumatic Diseases (1978)

the author accepts as a syndrome with high titre of antibodies to ribonucleoprotein and a favourable prognosis.The final chapter deals with immune complex disease and the complement system, followed by an appendix covering immu- nological tests in the rheumatic diseases.The book is well written, clearly set out, very readable, and covers a large field with commendable brevity.
PRODUCTION OF PULMONARY INFARCTS BY THE INSUFFLATION OF ACID
Authors: M. C. Winternitz, G. H. Smith, F. P. McNamara
Journal: The Journal of Experimental Medicine (1920)

Intrabronchial insufflation of acid causes immediate necrosis of the walls of many alveoli. Thrombosis of the alveolar vessels is an associated phenomenon. When a large number of vessels becomes affected, a clot propagates rapidly into the larger supplying vessels. The resulting lesion is indistinguishable from a hemorrhagic infarct. The infarct-like areas so frequently encountered in influenzal pneumonia, it is not unlikely, have their origin in a similar process. Infarction depends not only upon thrombosis or embolism of the large vessels, but may be initiated by extensive damage to the capillary bed. By this process infarcts may form in organs which are normally protected by collateral circulation.
Treatment of Verruca With Vaccinia
Authors: Burton Allyn
Journal: JAMA (1968)

To the Editor:—  Viral warts, especially when multiple, long have been the bane of dermatologists. Although numerous forms of therapy have been proposed for these lesions, including surgery, topical chemotherapy, application of irritating substances, and even charms, nonehave been ideal. A new approach has been suggested by McGee, who reported regression of verruca vulgaris lesions in 59 of 60 patients (164 of 165 warts) after intratumoral inoculation of smallpox vaccine. 1 There were no significant side effects nor was there any resultant scar formation. This remarkable response to what appeared to be a rather simple procedure stimulated us to attempt to reproduce the findings.  Methods:—  Our method was that described by McGee. Unattenuated smallpox vaccine was inoculated directily into warts by the multiplepuncture technique. A total of 32 verrucae in nine subjects, with a median age of 14 years, were treated  Results:—  Of the 32 warts treated, 20 regressed. Morbidity,
"Peripheral Resistance" in Hypertension Following the Abolition of Local Sympathetic Tone
Authors: FRANCIS S. CALIVA, JAY F. HARRIS, RICHARD H. LYONS
Journal: Circulation (1959)

Blood flows of the toe were studied before and after nerve block in normotensive and hypertensive patients, and an estimate of peripheral resistance was made. It was found that in all hypertensive patients there was an increased "peripheral resistance" at rest in the skin of the toe. Following abolition of sympathetic tone, the "resistance" in some individuals fell to a normal level, in others the "resistance" dropped less. The possible significance of these facts is discussed in the light of the etiologic factors responsible for the vasomotor tone.
Chronic hypercapnia and radiological changes in the pituitary fossa.
Authors: D A Newton, I Bone, G Bonsor
Journal: Thorax (1978)

A consecutive series of ten patients with chronic bronchitis and hypercapnia were studied. All seven patients with chronic hypercapnia and one patient with intermittent hypercapnia showed evidence on skull radiographs of raised intracranial pressure. In five male and three female chronic bronchitics matched for age and ventilatory impairment, but without hypercapnia, no such radiological abnormalities were shown. The clinical significance and pathophysiology of this hitherto unreported finding is discussed. It would appear that in some cases the chronicity of hypercapnia may be diagnosed from a radiograph of the pituitary fossa.
Prevalence of Diabetes and Its Risk Factors in China, 1994
Authors: Xiao-Ren Pan, Wen-Ying Yang, Guan-Wei Li, Juan Liu
Journal: Diabetes Care (1997)

OBJECTIVE To determine the prevalence of diabetes and impaired glucose tolerance (IGT) and its risk factors in the Chinese population. RESEARCH DESIGN AND METHODS This study was a population-based cross-sectional study of 224,251 residents aged 25–64 years in 19 provinces and areas, including cities and rural areas of the north, south, east, and middle part of China. RESULTS Using the 1985 World Health Organization criteria, the prevalence of diabetes and IGT was 2.5 and 3.2%, respectively, in 213,515 subjects aged 25–64 years. Two thirds (70.3%) of the cases had newly recognized diabetes. The prevalence of diabetes in China is about three times higher than it was 10 years ago. On average, subjects with diabetes are older, have higher personal annual incomes, and more often have a family history of diabetes. They also have higher mean BMI, waist-to-hip ratio (WHR), systolic blood pressure, diastolic blood pressure, and a greater prevalence of hypertension. They perform less physical activity and have less education than people with normal oral glucose tolerance test results. Multiple logistic stepwise regression analysis shows that age, BMI (or WHR), family history of diabetes, hypertension, less physical activity, and higher annual income are independent risk factors of NIDDM, and that low education is also an independent risk factor of NIDDM in people with higher personal annual income. CONCLUSIONS The prevalence of diabetes in China is increasing with economic development and changes from traditional to modernized lifestyle, especially where people had lower level of education and socioeconomic development. Therefore, Chinese people should attempt to retain certain features of their traditional lifestyle (physical activity, healthy food, moderate body weight). Increased knowledge of risk factors for diabetes may help to prevent a further rapid increase in the prevalence of diabetes in China.
Three-dimensional reconstruction of intracoronary ultrasound images. Rationale, approaches, problems, and directions.
Authors: J R Roelandt, C di Mario, N G Pandian, L Wenguang, D Keane, C J Slager, P J de Feyter, P W Serruys
Journal: Circulation (1994)

Although intracoronary ultrasonography allows detailed tomographic imaging of the arterial wall, it fails to provide data on the structural architecture and longitudinal extent of arterial disease. This information is essential for decision making during therapeutic interventions. Three-dimensional reconstruction techniques offer visualization of the complex longitudinal architecture of atherosclerotic plaques in composite display. Progress in computer hardware and software technology have shortened the reconstruction process and reduced operator interaction considerably, generating three-dimensional images with delineation of mural anatomy and pathology. The indications for intravascular ultrasonography will grow as the technique offers the unique capability of providing ultrasonic histology of the arterial wall, and the need for a three-dimensional display format for comprehensive analysis is increasingly recognized. Consequently, three-dimensional imaging is being rapidly implemented in the catheterization laboratories for guidance of intracoronary interventions and detailed assessment of their results. However exciting the prospects may be, three-dimensional reconstructions at present remain partially artificial because the true spatial position of the imaging catheter tip is not recorded, and shifts in its location and curves of the arterial lumen result in pseudoreconstructions rather than true reconstructions. In this report, we address the principles of three-dimensional reconstruction with a critical review of its limitations. Potential solutions for refinement of this exciting imaging modality are presented.
Up to 75% of epilepsy patients are not treated in many countries, says WHO
Authors: J. Zarocostas
Journal: BMJ (2010)

Most of the estimated 50 million people worldwide with epilepsy, most of whom live in poor nations, may be missing out on treatment, says a new study.

The proportion of people with epilepsy not being treated was over 75% in low income nations and over 50% in most lower middle and upper middle income nations, found the systematic review ( Bulletin of the World Health Organization , doi:10.2471/BLT.09.064147). But this treatment gap was less than 10% in many rich countries, it found.

WHO estimates that epilepsy, the most common neurological disorder, accounts for 0.5% of the …
Estradiol Alters Nitric Oxide Production in the Mouse Aorta Through the α-, but not β-, Estrogen Receptor
Authors: B. Darblade, C. Pendaries, A. Krust, S. Dupont, M.-J. Fouque, J. Rami, P. Chambon, F. Bayard, J.-F. Arnal
Journal: Circulation Research (2002)

Although estradiol (E 2 ) has been recognized to exert several vasculoprotective effects in several species, its effects in mouse vasomotion are unknown, and consequently, so is the estrogen receptor subtype mediating these effects. We investigated the effect of E 2 (80 μg/kg/day for 15 days) on NO production in the thoracic aorta of ovariectomized C57Bl/6 mice compared with those given placebo. E 2 increased basal NO production. In contrast, the relaxation in response to ATP, to the calcium ionophore A23187, and to sodium nitroprusside was unaltered by E 2 , whereas acetylcholine-elicited relaxation was decreased. The abundance of NO synthase I, II, and III immunoreactive proteins (using Western blot) in thoracic aorta homogenates was unchanged by E 2 . To determine the estrogen receptor (ER) subtype involved in these effects, transgenic mice in which either the ERα or ERβ has been disrupted were ovariectomized and treated, or not, with E 2 . Basal NO production was increased and the sensitivity to acetylcholine decreased in ERβ knockout mice in response to E 2 , whereas this effect was abolished in ERα knockout mice. Finally, these effects of E 2 on vasomotion required long-term and/or in vivo exposure, as short-term incubation of aortic rings with 10 nmol/L E 2 in the isolated organ chamber did not elicit any vasoactive effects. In conclusion, this study demonstrates that ERα, but not ERβ, mediates the beneficial effect of E 2 on basal NO production.
Prophylactic Cranial Irradiation in Small Cell Carcinoma of the Lung
Authors: Don V. Jackson, Frederick Richards, M. Robert Cooper, Carolyn Ferree, Hyman Bernard Muss, Douglas R. White, Charles L. Spurr
Journal: JAMA (1977)

Twenty-nine patients with small cell carcinoma of the lung and without evidence of brain metastasis were randomized into two treatment groups consisting of 14 patients who received prophylactic cranial irradiation (PCI) and 15 who received none (non-PCI). All patients were treated with irradiation of the primary lesion and concomitant chemotherapy. The response rate and median survival of the two groups were not significantly different: 93% and 7.2 months in the non-PCI; 86% and 9.8 months in the PCI; P larger than or equal to .05. Brain metastasis occurred in 0/14 patients in the PCI and 4/15 in the non-PCI (P less than or equal to .05) and was the cause of major neurologic disability in each. Although PCI did not improve response rate or survival, brain metastasis with its attendant neurologic complications was effectively prevented.
Guardians of Science: Fairness and Reliability of Peer Review
Authors: S Fletcher
Journal: BMJ (1994)

H-D Daniel, VCH, (pounds sterling)25, pp 118, ISBN 3-527-29041-9

Early this century an eccentric Boston surgeon, E A Codman, suggested that surgeons should follow up their patients to determine how often surgery was successful and to analyse failures for future improvement. He did exactly that by reporting the one year results in all his patients. His foreword to the resulting book read: “It is idle to consider the standardization of hospitals without considering the standard of the product of each hospital, the part which the professional staff plays in raising the standard of the …
Identification of anti–herpes simplex virus antibody–producing B cells in a patient with an atypical RAG1 immunodeficiency
Authors: Satoru Kumaki, Anna Villa, Hiroshi Asada, Shin Kawai, Yoshiyuki Ohashi, Miyoko Takahashi, Ikuko Hakozaki, Etsuko Nitanai, Masayoshi Minegishi, Shigeru Tsuchiya
Journal: Blood (2001)