tbuckley/cabot-search huggingface dataset:
Further Observations on the use of Pregnenolone in Rheumatoid Arthritis
Authors: G. N. Myers, D. N. Ross
Journal: Annals of the Rheumatic Diseases (1951)

In a recent report on the treatment by pregnenolone of a group of ten cases of rheumatoid arthritis (Myers, 1951), two instances of apparent clinical improve- ment occurred, although there was no appreciable reduction in the erythrocyte sedimentation rate or plasma viscosity readings.Accordingly, it was decided to study the effects of pregnenolone on the serum potassium, sodium, and chlorides, as well as on the urinary 17-ketosteroid excretion and leucocyte counts, to find whether any biochemical or hormonal changes parallel the minor clinical response.Scope of Present Investigation Four patients were selected for the investigation.All were females aged between 20 and 41 years, and the duration of the disease varied between 6 and 12 years.They were kept under observation as in-patients of the hospital.A brief outline of the clinical findings of each case is given.After examination, they were graded according to the system of Steinbrocker and others (1949).Two patients were given 300 mg.pregnenolone for 26 days and 100 mg. for 8 days; the other two received 300 mg. for 27 days and 100 mg. for 7 days.The drug was administered by the intramuscular and oral routes.Where the intramuscular route was employed, the pregnenolone was given in the form of a crystule suspension into the upper and outer quadrant of the buttock.The injections often caused pain and a mild inflammation at the site of the injection.In all such cases the volume of the injection was reduced or suspended entirely and the balance of the daily dose of 300 mg.given by the sublingual route.Estimations of the erythrocyte sedimentation rate (Spa Hospitals' Method), plasma viscosity, packed-cell volume, erythrocyte, leucocyte, and eosinophil counts, differential white-cell counts, and haemoglobin estimations, were made at set intervals, before and during the administration ofpregnenolone.In addition, estimations were made at intervals throughout the trial of the serum sodium, potassium, and chloride as well as the urinary excretion of 17-ketosteroids, creatinine, and uric acid.All four patients received routine physiotherapy throughout the trial period.Case Reports Case 1. Female, maffied, aged 38.-In 1944 she travelled to the West Indies, which necessitated a worrying sea trip of 3 weeks' duration via Greenland.About 4 months after her arrival, she developed pain and swelling in the left ankle.One month later the other ankle was similarly affected.She had " electric blanket " treatment, which gave some measure of relief.She returned to England after 7 months and, within 4 days of landing, showed signs of an acute polyarthritis involving the joints of both hands, 432 copyright.
Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues.
Authors: P Tekamp-Olson, C Gallegos, D Bauer, J McClain, B Sherry, M Fabre, S van Deventer, A Cerami
Journal: The Journal of Experimental Medicine (1990)

A cDNA clone of murine macrophage inflammatory protein 2 (MIP-2) has been isolated from a library prepared from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the nucleotide sequence determined. This cDNA was used to clone cDNAs for human homologues of MIP-2 from a library prepared from phorbol myristate acetate-treated and LPS-stimulated U937 cells. Two homologues were isolated and sequenced. Human MIP-2 alpha and MIP-2 beta are highly homologous to each other and to a previously isolated gene, human gro/melanoma growth-stimulating activity (MGSA). These three human genes, MIP-2 alpha, MIP-2 beta, and gro/MGSA, constitute a sub-family within the cytokine family represented by platelet factor 4 and interleukin 8.
Update in Nephrology: Evidence Published in 2013
Authors: Maria-Eleni Roumelioti, Mark Unruh
Journal: Annals of Internal Medicine (2014)

Updates1 July 2014Update in Nephrology: Evidence Published in 2013Maria-Eleni Roumelioti, MD and Mark Unruh, MD, MSMaria-Eleni Roumelioti, MDFrom University of New Mexico, Albuquerque, New Mexico.Search for more papers by this author and Mark Unruh, MD, MSFrom University of New Mexico, Albuquerque, New Mexico.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0263 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This update summarizes 8 important studies in nephrology, transplantation, and hypertension that are relevant to primary care. The authors screened the literature by using ACP JournalWise to identify articles for inclusion and subsequently considered additional late-breaking publications. Studies were selected to emphasize the provision of high-value care to patients by primary care providers and key basic scientific and translational discoveries in nephrology.This review examines a landmark trial in dual renin–angiotensin–aldosterone system (RAAS) blockade for treatment of diabetic nephropathy. The distribution and outcomes of hypertension among patients with kidney disease and a novel telemonitoring intervention to improve blood pressure (BP) ... Author, Article, and Disclosure InformationAffiliations: From University of New Mexico, Albuquerque, New Mexico.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-0263.Corresponding Author: Mark Unruh, MD, MS, Division of Nephrology, Department of Internal Medicine, University of New Mexico, MSC 10-5550, 1 University of New Mexico, Albuquerque, NM 87131.Current Author Addresses: Drs. Roumelioti and Unruh: Division of Nephrology, Department of Internal Medicine, University of New Mexico, MSC 10-5550, 1 University of New Mexico, Albuquerque, NM 87131.Author Contributions: Conception and design: M.E. Roumelioti, M. Unruh.Analysis and interpretation of the data: M. Unruh.Drafting of the article: M.E. Roumelioti, M. Unruh.Critical revision of the article for important intellectual content: M.E. Roumelioti, M. Unruh.Final approval of the article: M.E. Roumelioti, M. Unruh.Administrative, technical, or logistic support: M. Unruh.Collection and assembly of data: M.E. Roumelioti, M. Unruh.This article was published online first at www.annals.org on 10 April 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 2014Volume 161, Issue 1Page: 54-57KeywordsAutosomal dominant diseasesDeath ratesHypertensionKidneysNephrologyPolycystic kidney diseasePopulation statisticsRenal failureRenal transplantationVasculitis ePublished: 1 July 2014 Issue Published: 1 July 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
ANNULUS SIZE DETERMINATION BY COMPUTED TOMOGRAPHY IS RELIABLE AND REPRODUCIBLE IN TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Won–Jang Kim, Ho–Cheol Kim, Yong–Rak Cho, Jung–Min Ahn, Jong–Yong Lee, Duk–Woo Park, Soo–Jin Kang, Seung–Whan Lee, Young–Hak Kim, Cheol Whan Lee, Seong–Wook Park, Seung–Jung Park
Journal: Journal of the American College of Cardiology (2013)
Erythropoietic Protoporphyria Fluorescent Microscopic Evaluation.
Authors: John H. Epstein
Journal: Annals of Internal Medicine (1967)

s1 May 1967Erythropoietic Protoporphyria Fluorescent Microscopic Evaluation.John H. Epstein, M.D., F.A.C.P., Kirk D. Wuepper, M.D.John H. Epstein, M.D., F.A.C.P.Search for more papers by this author, Kirk D. Wuepper, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1058_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptErythropoietic protoporphyria (EPP) is genodermatosis characterized chemically by the presence of abnormal amounts of protoporphyrin in the red blood cells, the plasma, and the feces and, clinically, by an almost pathognomonic photocutaneous syndrome.Initially, the patients generally demonstrate a marked edema and, at times, eczematization confined to the sun-exposed areas. With repeated insults the skin becomes thickened, wrinkled, and leathery in appearance. Occasionally, urticarial and hydroa-like lesions are seen. The diagnosis is made from the clinical picture and confirmed by the detection chemically of abnormal amounts of protoporphyrine in the red blood cells. Recently, we have established that detection of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John H. Epstein, M.D., F.A.C.P.; Kirk D. Wuepper, M.D.Affiliations: San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1058-1058KeywordsBlood plasmaEdemaLesionsRed blood cells ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
Precipitation of Verapamil
Authors: DAVID BAR-OR
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 October 1982Precipitation of VerapamilDAVID BAR-OR, M.D., KENNETH KULIG, M.D., JOHN A MARX, M.D., PETER ROSEN, M.D.DAVID BAR-OR, M.D.Search for more papers by this author, KENNETH KULIG, M.D.Search for more papers by this author, JOHN A MARX, M.D.Search for more papers by this author, PETER ROSEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-4-619_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Verapmil has been recently approved by the FDA for the treatment of supraventricular tachycardia. Adverse reactions have occurred when verapamil has been used with various other drugs such as intravenous beta blockers (1), and calcium and vitamin D (2). Compatibility of verapamil with other additives has been reported (3). We report the precipitation of verapamil in an intravenous bicarbonate solution not previously described.A patient had high-voltage shock and presented to the emergency department in stable condition, but with new onset of atrial fibrillation. The ventricular rate was 150 min. An intravenous line of 0.45 normal saline...References1. SACKSKENNELLY HB. Verapamil in cardiac arrhythmias [Letter]. Br Med J. 1972;2:349. CrossrefGoogle Scholar2. BAR-ORGASIEL DY. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J. 1981;282:1585-6. CrossrefMedlineGoogle Scholar3. CUTIE M. Compatibility of verapamil hydrochloride with other additives. Am J Hosp Pharm. 1981;38:231. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID BAR-OR, M.D.; KENNETH KULIG, M.D.; JOHN A MARX, M.D.; PETER ROSEN, M.D.Affiliations: Denver General Hospital Denver, CO 80204 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCarboxylic AcidsAlkyl Chalcogenides: Oxygen-based Functional GroupsReferences to Volume 5Precipitation of Verapamil in an Intravenous LineROBERT TUCKER, M.S., R.Ph., JOHN F. GENTILE, M.D.Verapamil PrecipitationMARIA R. CUTIE, R.PH., M.S. 1 October 1982Volume 97, Issue 4Page: 619-619KeywordsAdverse reactionsAtrial fibrillationBicarbonatesCalciumEmergency departmentFood and Drug AdministrationSaline solutionsShockTachycardiaVitamin D ePublished: 1 December 2008 Issue Published: 1 October 1982 PDF downloadLoading ...
[596] GENOTYPE-SPECIFIC ASSESSMENT OF PREDICTIVE FACTORS FOR SUSTAINED VIROLOGIC RESPONSE AFTER STANDARD TREATMENT IN PATIENTS CHRONICALLY INFECTED WITH HCV
Authors: S. Martens, V. Weich, T. Berg, C. Sarrazin, H. Hinrichsen, P. Buggisch, U. Spengler, H. Klinker, S. Zeuzem, E. Herrmann
Journal: Journal of Hepatology (2007)
Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate Exposure
Authors: Shanna H. Swan, Katharina M. Main, Fan Liu, Sara L. Stewart, Robin L. Kruse, Antonia M. Calafat, Catherine S. Mao, J. Bruce Redmon, Christine L. Ternand, Shannon Sullivan, J. Lynn Teague
Journal: Environmental Health Perspectives (2005)

Prenatal phthalate exposure impairs testicular function and shortens anogenital distance (AGD) in male rodents. We present data from the first study to examine AGD and other genital measurements in relation to prenatal phthalate exposure in humans. A standardized measure of AGD was obtained in 134 boys 2-36 months of age. AGD was significantly correlated with penile volume (R = 0.27, p = 0.001) and the proportion of boys with incomplete testicular descent (R = 0.20, p = 0.02). We defined the anogenital index (AGI) as AGD divided by weight at examination [AGI = AGD/weight (mm/kg)] and calculated the age-adjusted AGI by regression analysis. We examined nine phthalate monoester metabolites, measured in prenatal urine samples, as predictors of age-adjusted AGI in regression and categorical analyses that included all participants with prenatal urine samples (n = 85). Urinary concentrations of four phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), and monoisobutyl phthalate (MiBP)] were inversely related to AGI. After adjusting for age at examination, p-values for regression coefficients ranged from 0.007 to 0.097. Comparing boys with prenatal MBP concentration in the highest quartile with those in the lowest quartile, the odds ratio for a shorter than expected AGI was 10.2 (95% confidence interval, 2.5 to 42.2). The corresponding odds ratios for MEP, MBzP, and MiBP were 4.7, 3.8, and 9.1, respectively (all p-values < 0.05). We defined a summary phthalate score to quantify joint exposure to these four phthalate metabolites. The age-adjusted AGI decreased significantly with increasing phthalate score (p-value for slope = 0.009). The associations between male genital development and phthalate exposure seen here are consistent with the phthalate-related syndrome of incomplete virilization that has been reported in prenatally exposed rodents. The median concentrations of phthalate metabolites that are associated with short AGI and incomplete testicular descent are below those found in one-quarter of the female population of the United States, based on a nationwide sample. These data support the hypothesis that prenatal phthalate exposure at environmental levels can adversely affect male reproductive development in humans.
Occupational exposure to dioxins by thermal oxygen cutting, welding, and soldering of metals.
Authors: H M Menzel, U Bolm-Audorff, E Turcer, H G Bienfait, G Albracht, D Walter, C Emmel, U Knecht, O Päpke
Journal: Environmental Health Perspectives (1998)

This paper focuses on one aspect of occupational dioxin exposure that is novel and unexpected. Exposures in excess of the German threshold limit value of 50 pg international toxicity equivalent (I-TEQ)/m3 are very frequent, unpredictable, and sometimes very high--up to 6612 pg I-TEQ/m3--during thermal oxygen cutting at scrap metal and demolition sites. The same procedure involving virgin steel in steel trade and mass production of steel objects gave no such evidence, even though no final conclusions can be drawn because of the low number of samples analyzed. Low dioxin exposures during inert gas electric arc welding confirm previous literature findings, whereas soldering and thermal oxygen cutting in the presence of polyvinyl chloride give rise to concern. The consequences of occupational dioxin exposure were studied by analysis of the dioxin-blood concentration, the body burden, of men performing thermal oxygen cutting at scrap metal reclamation and demolition sites, in steel trade and producing plants as well as for industrial welders and white-collar workers. The results concerning body burdens are in excellent agreement with the dioxin exposure as characterized by dioxin air concentration in the workplace. The significant positive correlation between duration and frequency of performing thermal oxygen cutting at metal reclamation and demolition sites expressed in job-years and dioxin body burden speaks for the occupational origin of the observed overload after long times. The results reported here lead to consequences for occupational health, which are discussed and require immediate attention.
Bush launches controversial mental health plan
Authors: Jeanne Lenzer
Journal: BMJ (2004)

President Bush announced on 26 July that his administration has begun implementing the recommendations of the New Freedom Commission on Mental Health to “improve mental health services and support for people of all ages with mental illness” through comprehensive screening.

The plan states that schools are in a “key position” to screen the “52 million students and six million adults who work at the schools” and includes recommendations for screening preschool children (19 June, p 1458).

Mr Bush's announcement comes after new reports showing that increasing numbers of toddlers and children are being prescribed amphetamines, anti-depressants, and antipsychotic drugs. Concern that widespread screening will only increase the number of young people taking drugs …
The Formyl Peptide Receptor 2 (FPR2) is Expressed on Human Eosinophils and its Upregulation by Dexamethasone (Dex) is Abrogated by Interleukin 2 and 4
Authors: K. Pazdrak, C. Straub, A. Kurosky
Journal: Journal of Allergy and Clinical Immunology (2010)
Infectious Mononucleosis Followed by Burkitt's Tumor
Authors: MARTIN H. COHEN
Journal: Annals of Internal Medicine (1970)

A 17-year-old American girl developed a tumor histologically and cytochemically identical to African Burkitt's tumor 16 months after having infectious mononucleosis. As the Epstein-Barr (EB) virus has been implicated as the causal agent of both diseases, studies to identify anti-EB virus antibody and EB virus antigen were performed. The patient was found to produce antibodies to EB virus. Although EB virus antigen could not be detected in any tissue taken directly from the patient, viral antigen was detected in buffy coat material after establishment in long-term culture. These studies indicate that there is either a different causal agent for these two diseases or that malignant transformation may have occurred during the acute phase of infectious mononucleosis, and 16 months later the tumor became clinically recognizable.
In vitro studies of epidermal antigen-presenting cells. The mixed skin lymphocyte reaction: an in vitro model for the generation of alloreactive cytotoxic T cells by human epidermal cells
Authors: M. FAURE, D. SGHMITT, G. DEZUTTER-DAMBUYANT, A. FRAPPAZ, M. GAUCHERAND, J. THIVOLET
Journal: British Journal of Dermatology (1984)

Langerhans cells and indeterminate cells are the unique antigen-presenting epidermal cells participating in human lympho-epidermal interactions. They bear class II HLA-DR molecules, can substitute for macrophages in antigen presentation, induce a T-cell proliferative response to antigens and haptens in sensitized donors, and are necessary for alloantigen T-cell activation and generation of alloreactive cytotoxic T cells in vitro. Indirect immunofluorescence and immunogold electron microscopy on class II positive epidermal cell enriched suspensions (panning, FACS) indicated two populations of DR-positive epidermal cells: strongly DR-positive cells (25-30, 8% of positive epidermal cells) and faintly DR-positive cells, with a density of surface DR sites of respectively 5 X 10(5) and 1 X 10(5). Most Langerhans cells are among this second group while indeterminate cells are usually strongly DR-positive. OKT6-labelled cells were only typical Langerhans cells.
Advances in Metabolic Disorders
Authors: S. Vaisrub
Journal: JAMA (1969)

At the molecular level scientific disciplines interlock. In this volume, which deals with fundamentals of disordered metabolism as they relate to clinical manifestations, endocrine topics predominate. Ectopic hormones, thyroid, ovary, LATS, and erythropoietin comprise two thirds of the contents. Autoimmunity commands the chapter on thyroid antibodies; experimental biology, that on diabetes and obesity in laboratory rodents; and high biochemistry and enzymology permeate the chapters on ketogenesis and the hypoglycemia induced by ethanol.  Surveying the literature, to which they themselves have made significant contributions, the authors provide critical comment, draw conclusions, and postulate hypotheses. Cogent on the whole, some of their views, such as Renold's on the sequence of events in the pathogenesis of diabetes and obesity, are open to challenge.  Involving several disciplines, the book is unavoidably uneven in length of discussions and depth of analyses. The reader must selectively extract information according to his interest and grasp of basic
Serum Lidocaine and MEGX Concentrations after Pharyngeal Anesthesia for Gastroscopy
Authors: K. Soda, K. Shimanuki, Y. Yoshida, N. Seo, T. Yamanaka, I. Sakurabayashi, M. Miyata
Journal: Endoscopy (1994)

In 20 patients undergoing topical anesthesia for gastroscopic examination, serum concentrations of lidocaine and its metabolite, monomethylglycinexylidide (MEGX), were measured. Patients were divided randomly into two groups: a gel group, in which 5 ml of 2% lidocaine gel was applied to the throat for 20 minutes; and a solution group, in which 40 ml of 2% lidocaine solution was administered by gargling for five minutes. The effect of oropharyngeal anesthesia was comparable in both groups. In the gel group, the serum levels of lidocaine and MEGX were not elevated at 15 minutes after application of the anesthetic. However, in the solution group, a rise in both serum lidocaine and MEGX at 15 minutes after anesthesia was detected in some of the patients (40%). Increased serum MEGX concentrations, which correlated well with serum lidocaine concentrations, were associated with the age of the patient (r = 0.606; p < 0.05), but not with height or weight. As a topical anesthetic for endoscopic examination, we prefer lidocaine gel to lidocaine solution, because the latter might be absorbed more rapidly and unpredictably in some, especially aged patients.
Rac Guanosine Triphosphatases Represent Integrating Molecular Therapeutic Targets for BCR-ABL-Induced Myeloproliferative Disease
Authors: Emily K. Thomas, Jose A. Cancelas, Hee-Don Chae, Adrienne D. Cox, Patricia J. Keller, Danilo Perrotti, Paolo Neviani, Brian J. Druker, Kenneth D.R. Setchell, Yi Zheng, Chad E. Harris, David A. Williams
Journal: Cancer Cell (2007)