tbuckley/cabot-search huggingface dataset:
Continuous 5-Fluorouracil Infusion Causing Acute Gastric Mucosal Lesions
Authors: K. Suda, T. Seki, Y. Kano, M. Sasagawa
Journal: Endoscopy (1993)

A 59-year-old woman with advanced gastric cancer was treated with continuous 5-fluorouracil infusion for thirty-five days. Endoscopy of the upper gastrointestinal tract was performed due to continuing nausea seven days after the cessation of 5-fluorouracil infusion and revealed multiple erosions in the antrum which were absent before chemotherapy. Continuous 5-fluorouracil infusion was probably the cause of acute gastric mucosal lesions and should be included in the differential diagnosis of dyspepsia in 5-FU-treated patients.
Successful surgical removal of a hepatoma
Authors: P. W. Houghton
Journal: Gut (1964)

EDITORIAL SYNOPSIS A case of hepatoma in a girl of 15 without pre-existing liver disease is reported.The growth was removed by partial hepatectomy, and, histologically, it had a low degree of malignancy.In patients with such tumours there may be a sudden and unheralded decline in general health, emphasizing the need for early diagnosis and expeditious surgical treatment.Primary tumours of the liver are sufficiently rare in the white-skinned races to excite interest, and Cruickshank (1961) estimates their necropsy incidence at 01450% in Great Britain, which corresponds well
OVER 20-YEAR TREND OF IN-HOSPITAL MORTALITY IN PATIENTS WITH CARDIOGENIC SHOCK USING PERCUTANEOUS EXTRACORPOREAL MEMBRANE OXYGENATION: COMPARISON BETWEEN ACS AND NON-ACS PATIENTS
Authors: Manabu Matsumoto, Satoshi Yasuda, Takafumi Yamane, Taichi Adachi, Tadayoshi Miyagi, Toshiyuki Nagai, Masashi Fujino, Yasuhide Asaumi, Reon Kumasaka, Tetsuo Arakawa, Jun-ichi Kotani, Hiroki Sakamoto, Teruo Noguchi, Yoichi Goto, Hiroyuki Yokoyama, Toshihisa Anzai, Wataru Shimizu, Masaharu Ishihara, Takeshi Nakatani, Junjiro Kobayashi, Hisao Ogawa
Journal: Journal of the American College of Cardiology (2013)
Fundamentals of Internal Medicine
Authors: Eddy D. Palmer
Journal: JAMA (1983)

By the end of the second week of this year, at least two brand new 1983 American textbooks on internal medicine had been published, one edited by Dr Jay H. Stein and this one, edited by Drs Kaye and Rose. Will either or both become classics, like the texts of Osler, Harrison, and others?  This text is divided into 206 chapters in 16 sections: examination of the patient, immunologic and allergic diseases, rheumatic and granulomatous diseases, microbial diseases, hematologic disorders, neoplastic diseases, cardiovascular diseases, genetics and metabolism, endocrinology, disorders of the digestive system, kidneys and electrolytes, respiratory diseases, environmental diseases, neurological diseases, skin diseases, and oral diseases. There are 12 section editors and 150 contributors. Short bibliographies follow the chapters. Illustrations are somewhat sparse. An appendix gives normal laboratory values. The index occupies 106 pages and is clearly well done.  Any criticism of a volume such as this seems irreverent
ILLEGITIMACY AN ECONOMIC PROBLEM.
Authors: JAMES E. DAVIS
Journal: JAMA (1904)

toms of epilepsy, those of athetosis and chorea were present.His anatomic study of the brain lesions led him to believe the walls of the cysts were, in part, formed by the vessels by which embolism occurred.In other parts of the body either the ova or worms have been found in the liver, orbital cavity, lower eye¬ lids, scrotum, mesentery, diaphragm, omentum and in the contents of the intestine.Thirty-one of the ova were measured by Dr. B. E. LeCount of Push Medical College, Chicago, care being taken to select such as were yet unbroken.7The sizes (see accompanying table) Avere found to correspond fairly well with the measurements given by most au¬ thorities, particularly those of Katsurada, ILLEGITIMACY AN ECONOMIC PEOBLEM.
A New Device for Abrasive Cytology Sampling During Upper Gastrointestinal Endoscopy: Experience in Infectious and Neoplastic Diseases
Authors: None Casco, None Martins, None Lettieri, None Rubio
Journal: Endoscopy (1999)

The quantity and variety of neoplastic and infectious pathologies which the endoscopist faces - and which have increased as a result of immunosuppression treatment, organ transplantation, chemotherapy, and acquired immune deficiency syndrome (AIDS) - have made it necessary to develop and apply simple, accurate, fast and low-cost methods that can easily be incorporated into routine endoscopy [1]. Various endoscopic treatment decisions would also benefit from the availability of fast diagnostic techniques that can ensure good-quality samples and provide better access to stenotic processes. We have developed a fast method that may help diagnose a variety of infectious processes in the gastrointestinal mucosa by identifying their etiology in a simple way. In addition, the technique can allow immediate diagnosis of endoscopically suspected neoplastic disease, so that treatment decisions can be taken without delay.
Effects of fluticasone propionate and beclomethasone dipropionate on parameters of inflammation in peripheral blood of patients with asthma
Authors: G. P. Bootsma, L. Koenderman, P. N. R. Dekhuijzen, J. Festen, J.‐W. J. Lammers, C. L A. van Herwaarden
Journal: Allergy (1998)

Bronchial inflammation plays a central role in asthma. We investigated whether parameters of inflammation were increased in peripheral blood. Furthermore, we tested whether fluticasone propionate (FP), a new inhaled corticosteroid (ICS), and beclomethasone dipropionate (BDP) affected these parameters. FP 750 μg/day and BDP 1500 μg/day were compared in a randomized, crossover study consisting of two 6‐week treatment periods, each preceded by a 3‐week placebo period. Twenty‐one patients with symptomatic asthma completed the study. The results were compared with those of six normal subjects (controls). Immunophenotyping of inflammatory cells was performed in whole blood, and serum eosinophil cationic protein (ECP) was measured. With regard to clinical efficacy, ICS increased PCjo histamine by more than 1.9 doubling doses and FEV, by more than 0.34 1. The number of CD3/HLA‐DR+ lymphocytes was significantly increased in asthmatics compared to the normal subjects, both after placebo (P&lt;0.01) and after therapy (P&lt;0.05). The CD3/HLA‐DR‐H lymphocytes decreased significantly after treatment with FP (P&lt;0.05). Serum ECP was elevated in patients without ICS and decreased after treatment with BDP (P&lt;0.001). In conclusion, the number of CD3/HLA‐DR‐I‐ lymphocytes and serum ECP levels were raised in the peripheral blood of symptomatic asthmatics, and decreased by clinically effective doses of ICS. In this respect, FP 750 ng/day was at least as effective as BDP 1500 μg/day.
Tools to Assess Clinical Skills of Medical Trainees
Authors: Isabelle Pitrou
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On Intratympanic Injections in Catarrhal Affections of the Middle Ear
Authors: None Weber-Liel
Journal: BMJ (1879)

produces a mucous secretion from the anus and considerable flow of tears.jaborandi is a name for several different South American plants ; e.g., a kind of pepper Seronia Jaborandi; a species of Herpestes, belonging to the nat.order of Scrophulariaceoe; pilocarpus pinnatifolius or pinnatus of Lemaire, a plant of the Rutaceae family.This latter appears to be the Alfovaea de Cobra of Brazil, introduced in I873 into the Hospital of Beaujon by Dr. Coutinho.Pilocarpine is the active principle of jaborandi.It forms crystalline salts with hydrochloric, nitric, and sulphuric acid.Hydrochlorate of -pilocarpine crystallises in long radiated needles.Pilocarpine-leaves contain also an oil-pilocarpane-having considerable affinity with oil of lemons.[The first precise experiments on the topical effects of the local application of extract of jaborandi to the eye were performed by Mr.
Disseminated verruciform xanthoma
Authors: J. Sopena, R. Gamo, L. Iglesias, J.L. Rodriguez-Peralto
Journal: British Journal of Dermatology (2004)

Journal Article Disseminated verruciform xanthoma Get access J. Sopena, J. Sopena Departments of DermatologyDepartment of Dermatology, Wake Forest University School of Medicine, Winston‐Salem, NC, U.S.A Search for other works by this author on: Oxford Academic Google Scholar R. Gamo, R. Gamo Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar L. Iglesias, L. Iglesias Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar J.L. Rodriguez‐Peralto J.L. Rodriguez‐Peralto Pathology, Hospital Universitario ‘12 de Octubre’, Avenida de Córdoba s/n, Madrid 28041, Spain J.L.Rodriguez‐Peralto. E‐mail: jrodriguezp.hdoc@salud.madrid.org Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 3, 1 September 2004, Pages 717–719, https://doi.org/10.1111/j.1365-2133.2004.06164.x Published: 01 September 2004
WHO calls for countries to shift from acute to chronic care
Authors: J. Whelan
Journal: BMJ (2002)

Primary care providers in developing countries are ill equipped to deal with chronic conditions, a new report from the World Health Organization says.

Defined as health problems that persist over time and require some degree of healthcare management, these conditions will be the leading cause of disability worldwide by 2020, it adds. Examples include diabetes, heart disease, depression and AIDS. These pose public health and economic threats to rich and poor countries alike, the report says.

The prevalence of chronic conditions is rising because of increased longevity, urbanisation, unhealthy lifestyles, and the spread of smoking. Yet healthcare systems throughout …
Acknowledging Levels of Racism in the Definition of “Difficult”
Authors: Melissa Creary, Arri Eisen
Journal: The American Journal of Bioethics (2013)

Bergman and Diamond (2013), referencing Fiester's article on the “difficult patient conundrum” (Feister 2012), have utilized sickle cell disease (SCD) as a case study to further refine and define t...
The Phagocytic Plasma Cells
Authors: Neil Abramson, Carola von Kapff, A. David Ginsburg
Journal: New England Journal of Medicine (1970)

PLASMA cells normally secrete immunoglobulins. On occasion, these cells may appear in unusual morphologic forms: grape cells; Mott cells; cells containing Russell bodies; multinuclear cells; thesaurocytes, or flaming cells; and cells with nuclear "dimples." Butterworth et al.1 described a patient with "plasma cell leukemia" whose plasma cells demonstrated erythrophagocytosis.We report here the phenomenon of phagocytosis of red cells, red-cell precursors, polymorphonuclear leukocytes and platelets by the plasma cells of two patients with well established multiple myeloma. The phagocytosis has persisted in one patient for two and a half years despite therapy with 1-phenylalanine mustard and corticosteroids.Case RecordsCase . . .
Abnormal function of B lymphocytes from peripheral blood of multiple myeloma patients. Lack of correlation between the number of cells potentially able to secrete immunoglobulin M and serum immunoglobulin M levels.
Authors: L M Pilarski, B A Ruether, M J Mant
Journal: Journal of Clinical Investigation (1985)

Multiple myeloma patients are deficient in normal polyclonal serum immunoglobulins. To determine the reasons for this decrease, we quantitated and compared the number of surface IgM+ B lymphocytes, and the number of B cells susceptible to transformation by Epstein-Barr virus (EBV) with the concentration of IgM in serum. Serum IgM levels varied considerably in individual patients, temporally shifting from undetectable to normal amounts and then dropping again to undetectable levels. A transient rise to normal serum IgM concentrations was seen in 42% of patients assessed at two or more time points. Of 44 patients, 52% showed a lack of correlation between the number of surface IgM+ (sIgM+) B cells and serum IgM concentration. One subset of patients (25%) had detectable to normal numbers of sIgM+ B cells in blood but undetectable levels of serum IgM. Transformation of B cells from these patients indicated a block in IgM secretion that was extrinsic to the B cells that were fully able to transcribe, translate, and secrete IgM after EBV transformation. A second subset of patients (27%) had undetectable numbers of sIgM+ B cells but near normal levels of serum IgM, suggesting abundant secretion by few clones of B cells. Of 18 patients with monoclonal gammopathy of undetermined significance (MGUS), 26% showed a lack of correlation between the numbers of sIgM+ B cells and serum IgM concentration. We suggest that in patients with multiple myeloma, and in some with MGUS, there exists a mechanism(s) extrinsic to the B cell that mediates an arrest in terminal B lymphocyte maturation.
Computed Tomography in Patients with Psychiatric Illnesses: Advantage of a "Rule-In" Approach
Authors: ERIC B. LARSON
Journal: Annals of Internal Medicine (1981)

Computed tomography (CT) is used commonly to "rule-out" disease. In 123 consecutive patients with psychiatric diseases in three institutions, 105 CT scans (85.4%) interpreted as normal or normal except for atrophy did not influence management, only reassured clinicians and patients. Incidental and false positive findings were more numerous than true positive findings. All six true positive findings occurred in patients with focal findings on neurologic examination; four led to management changes. The lower 95% confidence limit of the cost of case finding by CT only was estimated to be $2931 for all patients; $603 for patients with focal findings; and at least $7083 for patients without focal findings. Computed tomography is a sensitive diagnostic method that may detect more false and incidental positive findings when used somewhat unselectively to "rule-out" disease. In these patients, a "rule-in" approach based on focal findings on neurologic examination suggesting structural intracranial abnormalities would have been less expensive and more effective.
Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat
Authors: Sayyed Yazdan Asadi, Pouya Parsaei, Mehrdad Karimi, Sareh Ezzati, Alaleh Zamiri, Fereshteh Mohammadizadeh, Mahmoud Rafieian-kopaei
Journal: International Journal of Surgery (2013)
Methyldopa and associated thrombocytopenia.
Authors: S M Manohitharajah, W J Jenkins, P D Roberts, R C Clarke
Journal: BMJ (1971)

Indeed, Hand (1893) believed his original patient, a boy aged 3 with skull defects and polyuria, to be suffering from tuberculosis.This report re-emphasizes the importance of considering tuberculosis in immigrants presenting with unusual inflammatory and skeletal lesions.
The effect of microvascular dysfunction on the relationship between fractional flow reserve and anatomic stenosis severity
Authors: Seung-Jea Tahk, Myeong-Ho Yoon, So-Yeon Choi, Tae-Young Choi, Zhen-Guo Zheng, Zhe-Xun Lian, Gyo-Seung Hwang, Joon-Han Shin, Hyuk-Jae Chang, Byung-il W. Choi
Journal: Journal of the American College of Cardiology (2003)
Internal Medicine Chief Residents Want Changes in Education
Authors: Peter G. Tuteur
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
S6 The Role Of Individually Ventilated Cages In Prevention Of Laboratory Animal Allergy: A Proof Of Concept Study
Authors: J. Feary, Z. Lightfoot, B. FItzgerald, S. Schofield, M. Jones, P. Cullinan
Journal: Thorax (2014)

<h3>Introduction and objectives</h3> At least 12000 people work with laboratory animals in the UK. Approximately 15% of exposed employees develop specific IgE sensitisation and 10% clinical symptoms of laboratory animal allergy (LAA), a form of occupational asthma. Individually ventilated cages (IVCs) are increasingly replacing conventional open cages (primarily to protect mice from external infection) and whilst this can be associated with lower levels of ambient aeroallergen levels no corresponding reduction in the incidence of LAA is apparent. The SPIRAL (Safe Practice In Reducing Allergy in Laboratories) study is a large multi-centred study designed to increase understanding of the complex association between workplace exposure to mouse allergens and development of sensitisation, and to evaluate the risk of working with mice today. <h3>Methods</h3> A cross-sectional study of animal workers at seven UK medical research institutions is in progress. We aim to recruit 250 people working in IVC-only facilities and 160 people working in mixed facilities; our primary outcome is a comparison of prevalence of sensitisation to Mus m 1 (mouse urinary antigen) between these two groups. Participants are invited to complete a detailed online questionnaire about work tasks and practices. Skin-prick tests to common aeroallergens and various animal proteins are performed and blood samples analysed for serum specific IgE to Mus m 1. Aeroallergen sampling for particular matter and Mus m 1 is undertaken concurrently to provide additional information about potential exposures. Recently employed individuals are invited to participate in a cohort study to determine incidence rates of laboratory animal allergy. <h3>Results</h3> 136 individuals have been recruited to date; Table 1 shows their demographics and preliminary immunology results. Prevalence of allergic symptoms and sensitisation is similar to that anticipated. <h3>Conclusion</h3> The SPIRAL study is the largest, most detailed study of LAA to be carried out. It aims to increase understanding of the relationship between allergen exposure and risk of sensitisation with the goal of significantly reducing the incidence of LAA. The results will be used to develop a “Code of best working practices” for facilities using IVC systems, nationally and further afield.
An Ethical Dilemma: Commentary: Disciplinary processes should not be used to solve ethical problems
Authors: J. Short, G. Adshead
Journal: BMJ (1996)

The report suggests that managerially, it was apparently “wrong” for the nurse to deceive the patient (which justified the final warning) but not “wrong” for the doctor to have ordered the deception. This suggests that the ethical duties of doctors and nurses are perceived as different. However, it seems hard to argue that nurses should be more honest than doctors in their clinical practice unless it is important to protect a tradition of strong medical paternalism.

The author also raises concerns about a style of nursing management. Some of these concerns are not peculiar to nursing: the …
THE SPECIFIC TREATMENT OF CROUPOUS PNEUMONIA.
Authors: WILLSON O. BRIDGES
Journal: JAMA (1900)

The mortality of croupous pneumonia is greater than that of any other acute disease; higher than that of diphtheria, and next below that of tuberculosis. The mortality statistics in private and hospital practice show a percentage of from twenty to forty. The census of 1890 indicated that 76,496 persons died of pneumonia in the United States during the preceding year, a deathrate of 186.94 per 100,000 of population. The census reports of 1870, 1880 and 1890 show that the deaths from this disease have slightly increased. It is the most wide-spread of all acute diseases. It is nearly twenty years since Fränkel discovered the diplococcus lanceolatus and established its causative relation to croupous pneumonia, since which time renewed efforts have been, and are being, made for the discovery of a specific prophylactic and curative agent. Some years ago the Klemperers demonstrated that the injection of blood-serum, obtained from one who
Hypochondriacal Symptoms in Pregnancy
Authors: G. Savron, S. Grandi, L. Michelacci, F.M. Saviotti, G. Bartolucci, S. Conti, G. Trombini, L. Bovicelli, C. Orlandi, G.A. Fava
Journal: Psychotherapy and Psychosomatics (1989)

Illness attitudes were evaluated in 26 pregnant women and 26 control subjects matched for sociodemographic variables, by means of a self-rating scale, on three different occasions. In each trimester of pregnancy, women displayed more hypochondriacal fears and beliefs and conviction of disease (disease phobia) than normal controls (p less than 0.001). The findings should alert physicians to ask their pregnant patients whether they are preoccupied with fear of dying, or are concerned that they suffer from an undiagnosed physical illness, or dread a specific illness such as cancer or heart disease. Hypochondriacal fears and beliefs are liable to affect the well-being and health attitudes of pregnant women. If properly recognized, they may effectively be treated.