Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol
Authors: HARVEY LICHT
Journal: Annals of Internal Medicine (1980)

Brief Reports1 April 1980Apparent Potentiation of Acetaminophen Hepatotoxicity by AlcoholHARVEY LICHT, M.D., LEONARD B. SEEFF, M.D., HYMAN J. ZIMMERMAN, M.D.HARVEY LICHT, M.D.Search for more papers by this author, LEONARD B. SEEFF, M.D.Search for more papers by this author, HYMAN J. ZIMMERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-511_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNumerous reports describe severe hepatotoxic effects from large doses of acetaminophen ingested with suicidal intent (1). However, there are only occasional reports of hepatotoxicity from therapeutic doses of the drug (2, 3). We describe an additional case of acetaminophen hepatotoxicity in which multiple small doses of the drug were apparently potentiated by the concomitant use of alcohol.A 53-year-old man was admitted to the Veterans Administration Medical Center, Washington, D.C., with jaundice. He admitted to excessive alcohol intake for over 15 years, reporting the recent ingestion of 2 quarts of whiskey daily. He also had been taking eight to 12...References1. CLARKTHOMPSONBORIRAKCHANYAVAT RRV. Hepatic damage and death from overdose of paracetamol. Lancet. 1973;1:66-70. CrossrefMedlineGoogle Scholar2. BARKERDE CARLEANURAS JDS. Chronic excessive acetaminophen use and liver damage. Ann Intern Med. 1977;87:299-301. LinkGoogle Scholar3. KROMHOUTHOLTZMANNMCCLAIN JJC. Potentiation of acetaminophen hepatotoxicity by alcohol. Gastroenterology. 1977;76:1288. Abstract. Google Scholar4. MITCHELLJOLLOWPOTTERDAVISGILLETTEBRODIE JDWDJB. Acetaminophen-induced hepatic necrosis: 1. Role of drug metabolism. J Pharmacol Exp Ther. 1973;187:185-94. MedlineGoogle Scholar5. MITCHELLJOLLOWPOTTERGILLETTEBRODIE JDWJB. Acetaminophen-induced hepatic necrosis: IV. Protective role of glutathione. J Pharmacol Exp Ther. 1973;187:211-7. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center and the Universities of Georgetown and George Washington Medical Schools Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAre some people at increased risk of paracetamol-induced liver injury? 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PIROTTE, M.D.Interaction of ethanol with acetaminophen metabolism in the baboonEffects of Alcoholism on Acetaminophen Pharmacokinetics in ManHepatotoxicity following the therapeutic use of antipyretic analgesicsDrug interactions affecting analgesic toxicityIncreased acetaminophen-induced hepatotoxicity after chronic ethanol consumption in miceETHANOL IN PARACETAMOL POISONINGSUBSTANCE ABUSE AND THE GASTROINTESTINAL SYSTEMSevere hepatic damage after acetaminophen use in psittacosisLate presentation of acetaminophen hepatotoxicityPATTERNS OF HEPATOCYTE INJURY IN MANTherapeutic Drug Monitoring of Theophylline, Salicylates, and AcetaminophenEffects of microsomal enzyme induction on paracetamol metabolism in man.Alcohol and Drug Interactions in Injury to the Digestive TractActions and interactions of ethanol with drugs on intermediary metabolism 1 April 1980Volume 92, Issue 4Page: 511-511KeywordsAlcoholsDrugsIngestion Issue Published: 1 April 1980 PDF downloadLoading ...