tbuckley/cabot-search huggingface dataset:
The Surgical Treatment of Intracranial Fluid Pressure
Authors: J. B. Tuke
Journal: BMJ (1890)

my attention to the subject of the following case, who had been admitted the day be- fore into Ward 39 of the Royal Edinburgh Infirmary.I am in- debted to Dr. Muirhead for the clinical report, and for permission to publish it; and I give it in exteso, as the case presents the following points of interest: (1) the condition of the brain was ascertained during life; (2) the results of surgical operative pro- cedure were somewhat remarkable; and (3) its collation with another case in which surgical measures were adopted warrants various suggestions for the treatment of " head cases."R. S. W., male, aged 32, married, commercial traveller, admitted, at his wife's request, suffering from "strangeness of manner."Father died of heart disease; mother alive.No family history bearing on the case.History given by Wife and Mother.-Previous to present illness patient had been bright, clever, active, and sober.About four months before marriage his hair began to fall out, he suffered from sore throat and headache; was treated with mercury till his teeth became loose.Four months after marriage his wife noticed her own hair becoming thin; she suffered from sore throat, and she became somewhat deaf; six months after marriage she aborted, and a second time at the sixth month.Two children were subse- quently born, the eldest of which is barely seven.Patient's present illness commenced two months ago, when his mother noticed alternating conditions of depression and excitement.There was cause for depression, as he had lost his situation, and had made frequent unsuccessful attempts to get employment.His wit e said he would sit for days in the house, and not notice any mem- ber of the family.If she gave him a paper, he would look at it carelessly, and then allow it to drop from his hands as from those of a man falling asleep.At meals he would take up his spoon and fork instead of his knife and fork.If he showed any desire to go out, she noticed that he would wander into the lobby, then ack again to the sitting room, sit down, and forget his intention; this would happen several times a day.Memory failed in many ways; he would go out and stray about for hours, forgetting where he was.For three months previous to admission he had shown no sexual desire.
Abstract 805: Differential Regulation Of Cytokine-induced Alternative Splicing Of The TF Gene By Serine/Arginine Rich Protein Kinases
Authors: Ursula Rauch, Andreas Eisenreich, Wolfgang Poller, Heinz-Peter Schultheiss
Journal: Circulation (2007)

Background: Higher eukaryotes control gene expression and increase protein diversity by alternative splicing of pre-mRNA. The Cdc2-like kinase (Clk) family, DNA topoisomerase I (DNA topo I) or Akt kinase are involved in splicing control by regulating the phosphorylation state of serine/arginine rich (SR) proteins. We recently showed that alternatively spliced human tissue factor (asHTF), a soluble isoform of tissue factor (TF), the primary initiator of coagulation, is expressed in HUVECs in response to inflammatory cytokines. This study investigated the role of Clks, DNA topo I and the PI3K-Pathway in regulation of TF-splicing in TNF-α induced HUVECs. Methods: HUVECs were incubated with inhibitors of Clks, DNA-topo I or PI3K and were then stimulated with TNF-α. The SR protein phosphorylation state was determined 2 min post induction. The full length (fl) TF and asHTF mRNA were assessed 60 min post induction by Real-Time PCR. Proteins were measured 5 and 8 hours after stimulation by Western blots and the cell thrombogenicity was analyzed via a chromogenic assay. Results: TNF-α inceased the mRNA expression of asHTF and flTF in HUVECs. The Clk-inhibitor completely inhibited the TNF-α induced expression of asHTF and reduced flTF by 30 %. Inhibition of DNA topo I increased asHTF expression and reduced the flTF expression. Inhibition of the PI3K/Akt-pathway had no effect on TF mRNA expression. Reduced Clk-inhibition the TF activity by 50 % whereas DNA topo I inhibition significantly decreased the procoagulant TF activity 8 hours post TNF-α induction. The Clk- and DNA-topo I-inhibitors altered the SR-protein phosphorylation pattern post TNF-α-induction. Additionally resulted inhibition of Clks in the generation of a third TF mRNA-splice variant, TF-A. Conclusion: Selective inhibition of Clks or DNA topo I leads to alterations of SR-protein phosphorylation and affects the differential expression of TF isoforms, thereby modulating the thrombogenicity of HUVECs. The inhibition of Clks contributes to the generation of a third TF splice variant. The inhibition of these kinases gives new insights into the regulation of the TF gene splicing process, which may result in new therapeutic strategies for modulating cellular thrombogenicity.
An Epidemic of Undulant Fever With a Study of the Associated Milk Supply
Authors: Marian E. Farbar, Frank P. Mathews
Journal: Annals of Internal Medicine (1929)

Article1 March 1929An Epidemic of Undulant Fever With a Study of the Associated Milk SupplyMARIAN E. FARBAR, M.D., FRANK P. MATHEWS, D.V.M.MARIAN E. FARBAR, M.D.Search for more papers by this author, FRANK P. MATHEWS, D.V.M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-9-875 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBy no means a new, though as yet, an unsolved problem faces us in the seemingly sudden endemic appearance of undulant fever in this country. It is with the hope of aiding in the solution of its epidemiology and in the meantime to encourage a preventive campaign which would include as one of its objectives the control of the source of the infection that the present outbreak is brought to the attention of the Medical Profession.The patients and their milk supply were circumscribed on a college campus, hence a study of both the patients and the herd was possible.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBrucellosisDer neueste Stand der Forschung über das Bangsche BacteriumUndulant Fever (Brucelliasis)*†A Clinicopathologio Study of Ninety Cases Ocurring in and About Dayton, OhioWALTER M. SIMPSON, M.S., M.D., F.A.C.P. 1 March 1929Volume 2, Issue 9Page: 875-880KeywordsEpidemiologyFeversMilk Issue Published: 1 March 1929 PDF DownloadLoading ...
Early Gastric Cancer — Experience in Germany
Authors: K. Elster, F. Kolaczek, K. Shimamoto, H. Freitag
Journal: Endoscopy (1975)

The analysis of 87 cases of early gastric cancers does not demonstrate significant differences from findings which are reported in the Japanese literatur, above all as far as the macroscopic types, the histological pattern and the topographic distribution is concerned. The frequency of that diagnose during the fourth and fifth decade of the patients is hereby remarkable. The first biopsy allowed the diagnose of a carcinoma in the majority of all cases. The number of diagnosis of early gastric cancer increases together with the growing amount of gastric-bioptical examinations.
Cellular Architecture and Intercellular Communication in Rat Liver
Authors: J. P. Revel
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitric Oxide in Cirrhosis
Authors: Catherine Pastor
Journal: Annals of Internal Medicine (1998)

Letters15 June 1998Nitric Oxide in CirrhosisCatherine Pastor, MD, PhDCatherine Pastor, MD, PhDCentre Medical Universitaire; Geneva, SwitzerlandSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-12_Part_1-199806150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:By treating cirrhotic patients with fluoroquinolone to decrease circulating endotoxin and nitric oxide (NO) production, Chin-Dusting and colleagues [1] sought to reduce the impaired vascular response of the forearm circulation. Thus, it has been hypothesized that reduced reticuloendothelial function of the liver and portosystemic shunting permit endotoxin that originates from the gut to reach the systemic circulation and increase the release of NO (through the inducible NO synthase). Consequently, excess NO production may induce hypotension and impair the vascular response to various vasoactive drugs. As has been previously shown, NO production is increased in cirrhotic patients because ...References1. Chin-Dusting JP, Rasaratnam B, Jennings GL, Dudley FJ. Effect of fluoroquinolone on the enhanced nitric oxide-induced peripheral vasodilation seen in cirrhosis. Ann Intern Med. 1997; 127:985-8. Google Scholar2. Guarner C, Soriano G, Tomas A, Bulbena O, Novella MT, Balanzo J, et al. Increased serum nitrite and nitrate levels in patients with cirrhosis: relation to endotoxemia. Hepatology. 1993; 18:1139-43. Google Scholar3. Albillos A, Rossi I, Cacho G, Martinez MV, Millan I, Abren L, et al. Enhanced endothelium-dependent vasodilation in patients with cirrhosis. Am J Physiol. 1995; 268:G459-64. Google Scholar4. Evans T, Carpenter A, Kinderman H, Cohen J. Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shock. 1993; 41:77-81. Google Scholar5. Peters TS, Lewis SJ. Lipopolysaccharide inhibits acetylcholine- and nitric oxide-mediated vasodilation in vivo. J Pharmacol Exp. Ther. 1996; 279:918-25. Google Scholar Author, Article, and Disclosure InformationAffiliations: Centre Medical Universitaire; Geneva, Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1998Volume 128, Issue 12_Part_1Page: 1046KeywordsAcetylcholineAttentionBlood plasmaCirrhosisEndotoxinsHypotensionLiverNitratesNitric oxideVasodilation Issue Published: 15 June 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Overexpression of MBD2 in Glioblastoma Maintains Epigenetic Silencing and Inhibits the Antiangiogenic Function of the Tumor Suppressor Gene <i>BAI1</i>
Authors: Dan Zhu, Stephen B. Hunter, Paula M. Vertino, Erwin G. Van Meir
Journal: Cancer Research (2011)

Brain angiogenesis inhibitor 1 (BAI1) is a putative G protein-coupled receptor with potent antiangiogenic and antitumorigenic properties that is mutated in certain cancers. BAI1 is expressed in normal human brain, but it is frequently silenced in glioblastoma multiforme. In this study, we show that this silencing event is regulated by overexpression of methyl-CpG-binding domain protein 2 (MBD2), a key mediator of epigenetic gene regulation, which binds to the hypermethylated BAI1 gene promoter. In glioma cells, treatment with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-Aza-dC) was sufficient to reactivate BAI1 expression. Chromatin immunoprecipitation showed that MBD2 was enriched at the promoter of silenced BAI1 in glioma cells and that MBD2 binding was released by 5-Aza-dC treatment. RNA interference-mediated knockdown of MBD2 expression led to reactivation of BAI1 gene expression and restoration of BAI1 functional activity, as indicated by increased antiangiogenic activity in vitro and in vivo. Taken together, our results suggest that MBD2 overexpression during gliomagenesis may drive tumor growth by suppressing the antiangiogenic activity of a key tumor suppressor. These findings have therapeutic implications because inhibiting MBD2 could offer a strategy to reactivate BAI1 and suppress glioma pathobiology.
Changing patterns of iron deficiency anaemia in the second year of life
Authors: J. A James, G. J Laing, S. Logan
Journal: BMJ (1995)

Iron deficiency is the commonest cause of anaemia in children in the United Kingdom. It is associated with psychomotor delay that is reported to be reversible with iron treatment,1 2 although there may be later cognitive deficit.3 There has been considerable discussion about introducing screening for iron deficiency anaemia into routine child health surveillance.4 Screening is acceptable to parents and a high uptake is achievable,5 but the natural course of the disease remains poorly understood.

We examined the relation between iron deficiency anaemia at 14 months of age and the risk of anaemia at 2 years in a cohort of children attending a deprived inner city practice.

A total of 301 (92%) 14 month old children attending for immunisation had a blood sample taken by thumb prick for haemoglobin estimation; their parents were given dietary advice.5 Of these, 76 (25%) …
TCT-86 Safety and Performance of the Next Generation EnligHTN™ Renal Denervation System in Patients with Drug-resistant Hypertension: 24-Month Results From a First-in-Human Multicentre Study
Authors: Stephen G. Worthley, Gerry T. Wilkins, Mark W. Webster, Joseph Montarello, Paul Antonis, Robert J. Whitbourn, Roderic Warren
Journal: Journal of the American College of Cardiology (2015)
Primary Care Physicians Should Be Coordinators, Not Gatekeepers
Authors: Thomas Bodenheimer
Journal: JAMA (1999)

Primary care gatekeeping, in which the goal of the primary care physician (PCP) is to reduce patient referrals to specialists and thereby reduce costs, is not an adequate system in which to practice medicine. However, returning to the pre–managed care model of uncoordinated open access to specialists is a poor solution. The primary care model should be retained, but PCPs should be transformed from gatekeepers into coordinators of care, in which the goal of the PCP is to integrate both primary and specialty care to improve quality. Changes in the PCP's daily work process, as well as the referral and payment processes, need to be implemented to reach this goal. This model would eliminate the requirement that referrals to specialists be authorized by the primary care physician or managed care organization. Financial incentives would be needed, eg, to encourage PCPs to provide management of complex cases and discourage both overreferral and underreferral to specialists. Budgeting specialists should control excess costs that might be created by the elimination of the primary care gatekeeper. Pilot projects are needed to test and refine this model of PCP as coordinator of care.
Is teaching rewarding?
Authors: M. Vetpillai
Journal: BMJ (2015)

My father was a teacher in a small primary school in Sri Lanka. As a child in the school, I used to be proud when everyone praised him and said that he was a very good teacher and loved by all. When I was in secondary school, my brother and sister graduated and became teachers. Now it was time for me to decide what profession I should choose.

I too wanted to be a teacher and to be famous like my father and brother. However, the fact that my father was always poor with little income to support the family meant that I decided to study hard and become a doctor, hoping to leave behind the poverty and become famous.

After qualifying as the first doctor from my village, I got through my …
Torsion of the Spleen as a Rare Cause of Hypersplenism
Authors: Neal J. Weinreb
Journal: JAMA (1974)

TORSION of the spleen is a rare event that is seldom suspected preoperatively. The symptoms may be acute and fulminant, mimicking appendicitis, cholecystitis, peritonitis, or intestinal obstruction. Less often, the manifestations are chronic, fluctuating vague pains, anorexia, and weight loss accompanied by an abdominal or pelvic mass. Confusion with ovarian disease or intra-abdominal tumors is common. Hypersplenism, if noted preoperatively, might direct diagnostic attention to the spleen, but it is rarely reported, even in retrospect. We describe a patient with splenomegaly and hypersplenism who, at laparotomy, was found to have torsion of the spleen. <h3>Report of a Case</h3> A 46-year-old woman was admitted to the gynecologic service of the Mount Sinai Hospital in May 1971, after four days of persistent, cramping, periumbilical and left-flank pain, anorexia, nausea, and occasional vomiting. Fourteen years previously, she had undergone right ovarian cystectomy and uterine myomectomy. The patient was well until five months before
Anti-AIDS agents show varying early results in vitro and in vivo
Authors: D. E. Riesenberg
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
447 CANNABINOID RECEPTOR 2 (CB2) 63 QQ VARIANT IS ASSOCIATED WITH A SEVERE HISTOLOGICAL ACTIVITY INDEX IN PATIENTS WITH CHRONIC HEPATITIS C
Authors: N. Coppola, R. Zampino, G. Bellini, M. Macera, A. Marrone, M. Pisaturo, A. Boemio, B. Nobili, S. Maione, L.E. Adinolfi, E. Sagnelli, E. Miraglia del Giudice, F. Rossi
Journal: Journal of Hepatology (2013)
The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers
Authors: Takashi Kondo, Tadayuki Oshima, Toshihiko Tomita, Hirokazu Fukui, Hiroki Okada, Jiro Watari, Hiroto Miwa
Journal: Clinical Gastroenterology and Hepatology (2015)
Hypertension and ethnic group: Eplerenone may have role in hypertension related atrial fibrillation
Authors: Oscar M Jolobe
Journal: BMJ (2006)

EDITOR—Not with standing the fact that the preferred option for black people is the antihypertensive drug regimen comprising calcium channel blockers and diuretics,1 adjunctive treatment that reduces the risk of hypertension related atrial fibrillation also needs to be considered.

On meta-analysis, angiotensin converting …
BMA Annual Representative Meeting: Doctors recommend a “traffic light” system to signal nutritional content of food products
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

Food manufacturers should be forced by law to adopt a “traffic light” system to signal the nutritious content of all their products, doctors agreed at the BMA's annual conference of representatives in Belfast this week.

The system, which the Food Standards Agency first proposed in July 2004, has been rejected by some supermarkets. …
A case of concurrent antilaminin γ1 pemphigoid and antilaminin‐332‐type mucous membrane pemphigoid
Authors: X. Li, H. Qian, N. Ishii, M. Yamaya, H. Fukuda, H. Mukai, Y. Hirako, T. Hashimoto
Journal: British Journal of Dermatology (2014)

Journal Article A case of concurrent antilaminin γ1 pemphigoid and antilaminin‐332‐type mucous membrane pemphigoid Get access X. Li, X. Li Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology 67 Asahimachi Kurume Fukuoka 830‐0011 Japan Search for other works by this author on: Oxford Academic Google Scholar H. Qian, H. Qian Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology 67 Asahimachi Kurume Fukuoka 830‐0011 Japan Search for other works by this author on: Oxford Academic Google Scholar N. Ishii, N. Ishii Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology 67 Asahimachi Kurume Fukuoka 830‐0011 Japan Search for other works by this author on: Oxford Academic Google Scholar M. Yamaya, M. Yamaya Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan Search for other works by this author on: Oxford Academic Google Scholar H. Fukuda, H. Fukuda Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan Search for other works by this author on: Oxford Academic Google Scholar H. Mukai, H. Mukai Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Hirako, Y. Hirako Division of Biological Science Graduate School of Science Nagoya University Nagoya Aichi Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hashimoto T. Hashimoto Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology 67 Asahimachi Kurume Fukuoka 830‐0011 Japan Correspondence: Takashi Hashimoto. E‐mail: hashimot@med.kurume-u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 5, 1 November 2014, Pages 1257–1259, https://doi.org/10.1111/bjd.13107 Published: 01 November 2014
Efficacy of home-based peer counselling to promote exclusive breastfeeding: a randomised controlled trial
Authors: Ardythe L Morrow, M Lourdes Guerrero, Justine Shults, Juan J Calva, Chessa Lutter, Jane Bravo, Guillermo Ruiz-Palacios, Robert C Morrow, Frances D Butterfoss
Journal: The Lancet (1999)
Prevalence and Correlates of Prolonged Fatigue in a U.S. Sample of Adolescents
Authors: Femke Lamers, Ian Hickie, Kathleen R. Merikangas
Journal: American Journal of Psychiatry (2013)

Persistent fatigue is frequently comorbid with anxiety and depression and, even if it is not, can be a pathological condition that may not be recognized as such, thus resulting in no health care being sought despite the favorable treatment course in this population.