tbuckley/cabot-search huggingface dataset:
Dermoscopy of desmoplastic melanoma: report of six cases
Authors: S. Debarbieux, S. Ronger-Salve, S. Dalle, B. Balme, L. Thomas
Journal: British Journal of Dermatology (2008)

Journal Article Dermoscopy of desmoplastic melanoma: report of six cases Get access S. Debarbieux, S. Debarbieux Department of Dermatology, Lyon 1 University, Hôpital de l’Hôtel Dieu, 69288 Lyon CEDEX 02, France Search for other works by this author on: Oxford Academic Google Scholar S. Ronger‐Salve, S. Ronger‐Salve Department of Dermatology, Lyon 1 University, Hôpital de l’Hôtel Dieu, 69288 Lyon CEDEX 02, France Search for other works by this author on: Oxford Academic Google Scholar S. Dalle, S. Dalle Department of Dermatology, Lyon 1 University, Hôpital de l’Hôtel Dieu, 69288 Lyon CEDEX 02, France Search for other works by this author on: Oxford Academic Google Scholar B. Balme, B. Balme Department of Dermatology, Lyon 1 University, Hôpital de l’Hôtel Dieu, 69288 Lyon CEDEX 02, France Search for other works by this author on: Oxford Academic Google Scholar L. Thomas L. Thomas Department of Dermatology, Lyon 1 University, Hôpital de l’Hôtel Dieu, 69288 Lyon CEDEX 02, France Correspondence: Pr Luc Thomas, Service de dermatologie Hôtel Dieu 69288 Lyon France. E‐mail: luc.thomas@chu‐lyon.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 2, 1 August 2008, Pages 360–363, https://doi.org/10.1111/j.1365-2133.2008.08687.x Published: 01 August 2008
Impaired Baroreflex Sensitivity Is Correlated With Hemodynamic Deterioration of Sustained Ventricular Tachycardia
Authors: Maurizio Landolina, Massimo Mantica, Paolo Pessano, Ruggero Manfredini, Augusto Foresti, Peter J Schwartz, Gaetano M De Ferrari
Journal: Journal of the American College of Cardiology (1997)
Book Review The Principles and Practice of Ultrasonography in Obstetrics and Gynecology Fourth edition. Edited by Arthur C. Fleischer, Roberto Romero, Frank A. Manning, Philippe Jeanty, and A. Everette James, Jr. 668 pp., illustrated. Norwalk, Conn., Appleton and Lange, 1991. $95.
Authors: Thomas B. Jones
Journal: New England Journal of Medicine (1991)
MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma
Authors: Heidi Rye Hudlebusch, Julie Skotte, Eric Santoni-Rugiu, Zarah Glad Zimling, Michael James Lees, Ronald Simon, Guido Sauter, Rossella Rota, Maria Antonietta De Ioris, Micaela Quarto, Jens Vilstrup Johansen, Mette Jørgensen, Catherine Rechnitzer, Lisa Leth Maroun, Henrik Schrøder, Bodil Laub Petersen, Kristian Helin
Journal: Cancer Research (2011)

MMSET (WHSC1/NSD2) is a SET domain-containing histone lysine methyltransferase the expression of which is deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation associated with poor prognosis. Recent studies have shown that MMSET mRNA levels are increased in other tumor types as well. We have carried out immunohistochemical staining of tissue microarrays and found that MMSET protein is frequently and highly expressed in neuroblastoma (MMSET positive in 75% of neuroblastomas, n = 164). The expression level of MMSET in neuroblastomas was significantly associated with poor survival, negative prognostic factors, and metastatic disease. Moreover, a subset of neuroblastomas for which pre- and postchemotherapy biopsies were available displayed a strong decrease in MMSET protein levels after chemotherapy. In agreement with neuroblastomas becoming more differentiated after treatment, we show that retinoic acid-induced differentiation of human neuroblastoma cells in vitro also leads to a strong decrease in MMSET levels. Furthermore, we show that the high levels of MMSET in normal neural progenitor cells are strongly downregulated during differentiation. Importantly, we show that MMSET is required for proliferation of neuroblastoma cells and brain-derived neural stem cells. Taken together, our results suggest that MMSET is implicated in neuroblastomagenesis possibly by supporting proliferation of progenitor cells and negatively regulating their differentiation. In this respect, MMSET might be a strong candidate therapeutic target in a subset of neuroblastomas with unfavorable prognosis.
Fire in the Operating Room Caused by Fluid From Suture Packet
Authors: Robert A. Buyers
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Fire in the modern operating room is rare. I wish to report a fire that occurred during an appendectomy and was caused by the fluid in which catgut sutures were packed. <h3>Report of a Case.—</h3> In the course of a difficult appendectomy, the scrub nurse held the retractor with one hand and at the same time (when able) broke sutures over a kidney basin adjacent to the operating field. The base of the appendix was cauterized by heat, and suddenly the entire operative field became enveloped in flames (including a portion of the drapes). The fire was quickly extinguished and produced only second-degree burns on the abdominal wall of the patient. The obvious cause was the catgut packing fluid (containing isopropyl alcohol), which had spilled from the nurse's basin and had soaked some of the sponges and drapes. This episode emphasized the well-known hazard of using inflammable
Commentary: managing oesophageal cancer in a resource poor setting--a Malawian example
Authors: A. Thumbs, E. Borgstein
Journal: BMJ (2010)

The incidence of cancer of the oesophagus is increasing worldwide.1 Countries with adequate resources now have a range of diagnostic and treatment options for patients with this disease; unfortunately the situation in resource poor settings is hugely different.

Oesophageal cancer is the sixth most common cancer in Malawi2 with almost equal proportions in men and women. By contrast with western Europe, adenocarcinoma is rare; more than 90% of patients present with squamous cell carcinoma. Accepted risk factors such as smoking and alcohol (especially home brewed spirit) play a part in the pathogenesis of this condition in Africa, as elsewhere, but other factors need to be …
Hospital Performance for Pharmacologic Venous Thromboembolism Prophylaxis and Rate of Venous Thromboembolism
Authors: Scott A. Flanders, M. Todd Greene, Paul Grant, Scott Kaatz, David Paje, Bobby Lee, James Barron, Vineet Chopra, David Share, Steven J. Bernstein
Journal: JAMA Internal Medicine (2014)

Hospitalization for acute medical illness is associated with increased risk of venous thromboembolism (VTE). Although efforts designed to increase use of pharmacologic VTE prophylaxis are intended to reduce hospital-associated VTE, whether higher rates of prophylaxis reduce VTE in medical patients is unknown.To examine the association between pharmacologic VTE prophylaxis rates and hospital-associated VTE.Retrospective, multicenter cohort study conducted at 35 Michigan hospitals participating in a statewide quality collaborative from January 1, 2011, through September 13, 2012. Trained medical record abstractors at each hospital collected data from 31 260 general medical patients. Use of VTE prophylaxis on admission, VTE risk factors, and VTE events 90 days after hospital admission were recorded using a combination of medical record review and telephone follow-up. Hospitals were grouped into tertiles of performance based on rate of pharmacologic prophylaxis use on admission for at-risk patients.Association between hospital performance and time to development of VTE within 90 days of hospital admission.A total of 14 563 of 20 794 patients (70.0%) eligible for pharmacologic prophylaxis received prophylaxis on admission. The rates of pharmacologic prophylaxis use at hospitals in the high-, moderate-, and low-performance tertiles were 85.8%, 72.6%, and 55.5%, respectively. A total of 226 VTE events occurred during 1 765 449 days of patient follow-up. Compared with patients at hospitals in the highest-performance tertile, the hazard of VTE in patients at hospitals in moderate-performance (hazard ratio, 1.10; 95% CI, 0.74-1.62) and low-performance (hazard ratio, 0.96, 95% CI, 0.63-1.45) tertiles did not differ after adjusting for potential confounders. Results remained robust when examining mechanical prophylaxis, prophylaxis use throughout the hospitalization, and subsequent inpatient stays after discharge from the index hospitalization.The occurrence of 90-day VTE in medical patients after hospitalization is low. Patients who receive care at hospitals that have lower rates of pharmacologic prophylaxis do not have higher adjusted hazards of VTE, even after accounting for individual receipt of pharmacologic prophylaxis. Efforts to increase rates of pharmacologic VTE prophylaxis in hospitalized medical patients may not substantively reduce this adverse outcome.
Overexpression of cholesterol transporter StAR increasesIn Vivo rates of bile acid synthesis in the rat and mouse
Authors: Shunlin Ren, Phillip B. Hylemon, Dalila Marques, Emily Gurley, Patricia Bodhan, Elizabeth Hall, Kaye Redford, Gregorio Gil, William M. Pandak
Journal: Hepatology (2004)

Bile acid synthesis (BAS) occurs mainly via two pathways: the “neutral” pathway, which is initiated by highly regulated microsomal CYP7A1, and an “acidic” pathway, which is initiated by mitochondrial CYP27A1. Previously, we have shown that overexpression of the steroidognic acute regulatory protein (StAR), a mitochondrial cholesterol transport protein, increases bile acid biosynthesis more than 5-fold via the acidic pathway in primary rat hepatocytes. This observation suggests that mitochondrial cholesterol transport is the ratelimiting step of BAS via this pathway. The objective of this study was to determine the effect of increased StAR on rates of BAS in vivo. Overexpression of StAR and CYP7A1 were mediated via infection with recombinant adenoviruses. BAS rates were determined in chronic biliary-diverted rats and mice, and in mice with an intact enterohepatic circulation. The protein/messenger RNA levels of StAR and CYP7A1 increased dramatically following overexpression. Overexpression of StAR or CYP7A1 led to a similar 2-fold ( P &lt; .01) increase in BAS over up-regulated (approximately 2-fold) 3-day chronic biliary-diverted control rats. Additionally, overexpression of StAR led to more than 3- and 6-fold increases over controls in the rates of BAS in biliary-diverted and intact mice, respectively ( P &lt; .01). In conclusion, in both rats and mice in vivo , overexpression of StAR led to a marked increase in the rates of BAS initiated by delivery of cholesterol to mitochondria containing CYP27A1. (Hepatology 2004;40:910-917).
CDP571, a humanised monoclonal antibody to tumour necrosis factor , for moderate to severe Crohn's disease: a randomised, double blind, placebo controlled trial
Authors: W J Sandborn
Journal: Gut (2004)

Targeting tumour necrosis factor alpha (TNF-alpha) has demonstrated efficacy in Crohn's disease.To evaluate CDP571, a humanised antibody to TNF-alpha, for treating active Crohn's disease.A total of 396 patients with moderate to severe Crohn's disease.In a 28 week, randomised, double blind, placebo controlled trial, patients received intravenous CDP571 (10 mg/kg) or placebo every eight weeks to week 24. The primary outcome measure was clinical response (a decrease in the Crohn's disease activity index (CDAI) to > or =100 points or remission (CDAI score < or =150 points)) at week 28. A secondary outcome measure was clinical response (using the same definition) at week 2.Clinical response occurred at week 28 in 80/263 (30.4%) CDP571 patients and 31/132 (23.5%) placebo patients (p = 0.102). Clinical response at week 2 occurred in 90/263 (34.2%) CDP571 patients and 28/132 (21.2%) placebo patients (p = 0.011). Post hoc exploratory subgroup analysis of 159 patients with baseline C reactive protein (CRP) > or =10 mg/l demonstrated significant differences between CDP571 and placebo in clinical response rates at weeks 2 (CDP571, 50/101 (49.5%); placebo, 9/58 (15.5%); p<0.001) and 28 (CDP571, 29/101 (28.7%); placebo, 7/58 (12.1%); p = 0.018). Adverse events occurred at similar frequencies in both treatment groups.CDP571 is modestly effective for short but not long term treatment of unselected patients with moderate to severe Crohn's disease. The clinical relevance of this short term effect is unclear. Post hoc analysis suggests both short and long term efficacy of CDP571 in patients with elevated baseline CRP (> or =10 mg/l). CDP571 is well tolerated.
TRENDS OF ACUTE MYOCARDIAL INFARCTION AMONG PATIENTS YOUNGER THAN 35, A 22-YEAR STUDY
Authors: Yingzi Deng, Abel E. Moreyra, Abate Mammo, Emmanuel A. Noggoh, Nora M. Cosgrove, William J. Kostis, Alan C. Wilson, John B. Kostis
Journal: Journal of the American College of Cardiology (2011)
Retinal signal transmission in Duchenne muscular dystrophy: evidence for dysfunction in the photoreceptor/depolarizing bipolar cell pathway.
Authors: K M Fitzgerald, G W Cibis, S A Giambrone, D J Harris
Journal: Journal of Clinical Investigation (1994)

There have been reports of abnormal retinal neurotransmission determined by electroretinography in boys with Duchenne and Becker muscular dystrophy. Dystrophin may play a role in transmitting signals between photoreceptors and the excitatory synapse of the ON-bipolar cell. These electroretinographic changes appeared to be limited to the rod ON-pathway but we felt there was also similar abnormality in the cone ON-pathway. We used long-duration stimuli to separate ON-(depolarizing bipolar cell) and OFF (hyperpolarizing bipolar cell) contributions to the cone-dominated ERG to better understand how the retina functions in boys with Duchenne muscular dystrophy. We recorded the electroretinograms of 11 boys with Duchenne muscular dystrophy and found abnormal signal transmission at the level of the photoreceptor and ON-bipolar cell in both the rod and cone generated responses. The OFF-bipolar cell that responds to the offset of the stimulus continues to function normally. The results support our hypothesis that retinal dystrophin plays a role in receptor function or controlling ion channels at the level of the photoreceptor and depolarizing bipolar cell.
WHAT THRESHOLD SHOULD BE USED TO DEFINE PERCUTANEOUS CORONARY INTERVENTION-RELATED MYOCARDIAL INFARCTION? AN APPROACH BASED ON CLINICAL RELEVANCE FROM EARLY ACS AND SYNERGY
Authors: Sergio Leonardi, Laine Thomas, Megan L. Koehler, Pierluigi Tricoci, Renato D. Lopes, Harvey D. White, Paul W. Armstrong, L. Kristin Newby
Journal: Journal of the American College of Cardiology (2011)
Africa does not need aid, but the opportunity for fair trade
Authors: Inwani Malweyi
Journal: BMJ (2005)

A frica has been in the international news mostly for the wrong reasons and notably in the recent past for famine, the HIV/AIDS pandemic, civil wars, and increasing poverty. It is common knowledge that the continent is rich in natural resources, but its people continue to languish in absolute poverty. Some factors that could explain this are corruption, unequal distribution of wealth, poor planning, lack of respect for the rule of law, manipulation by developed countries, civil wars, illiteracy, and the current HIV/AIDS pandemic. All these factors have worked in synergy to reverse the little gain the continent had made in the early 1970s.

Most African countries have welcomed recent debate (such as that at the G8 summit in Gleneagles, Scotland, in July of this year) on increased aid and debt relief to impoverished nations by the world's leading industrialised countries. It is important to note, however, that such pledges have been made before, and yet poverty levels have increased. Rich nations, and G8 nations in …
Points: We need more female values in medicine
Authors: I. Weinreb
Journal: BMJ (1983)

write: Dr Lightman (6 August, p 422) has missed the point.We were not reviewing the variety of lesions that might provoke hot flushes.The object of our case presentation (23 July, p 262) was the objective demonstration that climacteric flushing in a man was associated with circulatory responses virtually identical to those we had shown during the meno- pausal hot flush.'Every blush is not a flush, however, and until the phenomena reported in different circumstances in either sex are recorded by tech- niques capable of following the rapid circulatory changes that occur during the hot flush our under- standing of the mechanisms responsible for the menopausal hot flush will remain obscure.
PREDICTORS OF MORTALITY IN PATIENTS WITH AORTIC STENOSIS UNDERGOING SURGICAL AORTIC VALVE REPLACEMENT: A CONTEMPORARY APPRAISAL
Authors: Roosha Parikh, Andrew Goodman, Tyler Barr, Joseph Sabik, Lars Svensson, L. Leonardo Rodriguez, Bruce Lytle, Richard Grimm, Brian Griffin, Milind Desai
Journal: Journal of the American College of Cardiology (2014)
Modulation of in vivo cardiac hypertrophy with insulin-like growth factor-1 and angiotensin-converting enzyme inhibitor: relationship between change in myosin isoform and progression of left ventricular dysfunction
Authors: Yoshitaka Iwanaga, Yasuki Kihara, Takeshi Yoneda, Takeshi Aoyama, Shigetake Sasayama
Journal: Journal of the American College of Cardiology (2000)
Childhood deaths from intussusception in England and Wales, 1984-9.
Authors: M. D. Stringer, G. Pledger, D. P. Drake
Journal: BMJ (1992)

OBJECTIVE--To assess the incidence of potentially avoidable factors contributing to death of children with intussusception. DESIGN--Review of children who died with intussusception in England and Wales between 1984 and 1989 from data of the Office of Population Censuses and Surveys, case notes, coroners9 records, and necropsy reports. MAIN OUTCOME MEASURES--Unambiguous objective criteria such as failure to diagnose intussusception within 24 hours of admission. RESULTS--33 children died of acute intussusception in England and Wales between 1984 and 1989 compared with 67 in the previous six years. Their median age was 7 months (range 2 months to 12 years), and two thirds were boys. Half of the deaths occurred at home or soon after arrival at hospital but 15 patients had surgery. Potentially avoidable factors contributing to death were identified in 20 (61%) children, all but three of whom had ileocolic intussusception. These factors were excessive delay in diagnosis, inadequate intravenous fluid and antibiotic therapy, delay in recognising recurrent or residual intussusception after hydrostatic reduction, and surgical complications. Of the 13 patients in whom no avoidable factors were identified, there were nine of 11 children with isolated small bowel intussusception, who tended to have atypical presentations. CONCLUSION--Although the mortality from intussusception has declined, there remains ample opportunity for improved management.
Sequential immunizations with rgp120s from independent isolates of human immunodeficiency virus type 1 induce the preferential expansion of broadly crossreactive B cells.
Authors: D M Klinman, K W Higgins, J Conover
Journal: The Journal of Experimental Medicine (1991)

The gp120 envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) is a dominant target against which the host's humoral immune response is directed. Unfortunately, gp120 proteins from different isolates of HIV are antigenically distinct, complicating the use of the envelope glycoprotein in vaccines designed to prevent acquired immunodeficiency syndrome. Using an enzyme-linked immunosorbent spot assay (ELISA), BALB/c mice immunized and boosted with recombinant purified gp120 were studied at the single cell level for their humoral immune response to HIV-1 envelope proteins. Approximately 90% of responding B cells produced antibodies reactive with the immunizing form of gp120 but not with gp120s from other strains of HIV. A novel sandwich ELISA was then used to analyze the frequency with which individual in vivo activated B cells produced antibodies that crossreacted with heterologous gp120s. Repeated immunizations with a single gp120 or with a mixture of different gp120s resulted in the activation of primarily mono-specific (noncrossreactive) B cells. In contrast, the sequential immunization of mice with recombinant purified envelope proteins from different strains of HIV (IIIB, SF2, and Zr6) induced the selective expansion of B cells producing highly crossreactive antibodies.
Spontaneous Movements in Brain-Dead Patients
Authors: Thomas J. Poulton
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Dr Liptak<sup>1</sup>is to be congratulated for articulating with sensitivity some of the insights gained by those who confront the death of children. This reader, however, was stunned by his statement about the "disconcerting" aspects of disconnecting children from ventilators: "They shudder and gasp and twitch and inevitably lead you to believe that you have made a mistake and should not have disconnected them." Disconcerting indeed! Contemporary medical practice affords few indications for disconnecting seriously ill patients from ventilators. In the context presented, ventilatory support is withdrawn when brain death has been established. Readers ofThe Journalshould understand clearly that patients who have been competently diagnosed to be brain dead neither shudder, nor gasp, nor twitch when ventilatory support is disconnected. The absence of such responses is, in fact, part of the process of certification of brain death.<sup>2</sup> It would be reassuring were Dr
CARBOHYDRATES ADSORBED ON COLLOIDS AS ANTIGENS
Authors: José Zozaya
Journal: The Journal of Experimental Medicine (1932)

Evidence is here given that polysaccharides can be rendered antigenic by haptogenic adsorption upon a colloid carrier. The polysaccharides studied were those of B. anthracis, the meningococcus, Streptococcus viridans (Bargen), B. proteus, S. morgani, B. dysenteriae, both the Shiga and Hiss types, and the pneumococci. With the polysaccharide of Type III pneumococci, we have been unable in 6 weeks to produce any detectable protective antibodies, but we were able to produce anticarbohydrate antibodies. All the bacterial carbohydrates were non-antigenic alone when used in the doses indicated, though containing some nitrogen. Dextran, which was free from nitrogen was also rendered antigenic by the adsorption method.
Large-scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope
Authors: H. Sugiura, H. Ebise, T. Tazawa, K. Tanaka, Y. Sugiura, M. Uehara, K. Kikuchi, T. Kimura
Journal: British Journal of Dermatology (2005)

Atopic dermatitis (AD)-specific genes have not yet been clarified. Objectives To identify gene expression specific to active atopic skin lesions.We analysed 23,000 genes in skin biopsy samples from 17 patients with AD and four normal controls using Affymetrix oligonucleotide arrays.Four of the 10 genes with the greatest differences in expression between patients and controls, S100A8 and S100A7 (upregulated), and loricrin and filaggrin (downregulated), were epidermal differentiation genes located on 1q21, a locus previously reported to have a genetic linkage with AD.Our results, showing downregulation of the cornified envelope genes and upregulation of the alternative keratinization pathway, are the first to suggest abnormal epidermal differentiation and defective defences as key abnormalities in AD.