tbuckley/cabot-search huggingface dataset:
Functional role of collateral flow in the ischaemic dog heart
Authors: J. R. KOKE, N. BITTAR
Journal: Cardiovascular Research (1978)

Journal Article Functional role of collateral flow in the ischaemic dog heart Get access JOSEPH R. KOKE, JOSEPH R. KOKE 1 From the Cardiovascular Section, Department of Medicine, University of Wisconsin Medical School 1Reprint requests to: Joseph R. Koke, PhD, Cardiovascular Section, Room 523, 420 N. Charter Street, Madison, WI 53706, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar NEVILLE BITTAR NEVILLE BITTAR From the Cardiovascular Section, Department of Medicine, University of Wisconsin Medical School Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 12, Issue 5, May 1978, Pages 309–315, https://doi.org/10.1093/cvr/12.5.309 Published: 01 May 1978
GP surgeries with poor access told to improve
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

General practices in England where patients have reported difficulty getting to see a doctor have been told to improve their services.

Most patients in England are happy with their ability to get an appointment to see a GP, show the results of the biggest ever survey about access to GPs commissioned by the Department of Health. But there are pockets around the country where retaining GPs remains a problem, and some communities are less satisfied with their experience of accessing general practice.

Areas in which there are problems of access are being asked to produce local action plans to improve their services, and primary care trusts have been told by the department to use their existing powers to invite new providers to offer high quality responsive services for patients.

Alan Johnson, the health secretary, who announced the measures this week, said, “I am particularly concerned about areas of deprivation where there is …
Digital angiography in the pediatric patient with congenital heart disease: comparison with standard methods.
Authors: A R Levin, H L Goldberg, J S Borer, L N Rothenberg, F A Nolan, M A Engle, B Cohen, N T Skelly, J Carter
Journal: Circulation (1983)

Digital subtraction angiography (DSA) permits high-resolution cardiac imaging with relatively low doses of contrast medium and reduced radiation exposure. These are potential advantages in children with congenital heart disease. Computer-based DSA (30 frames/sec) and conventional cutfilm angiography (6 frames/sec) or cineangiography (60 frames/sec) were compared in 42 patients, ages 2 months to 18 years (mean 7.8 years) and weighing 3.4 to 78.5 kg (mean 28.2 kg). There were 29 diagnoses that included valvular regurgitant lesions, obstructive lesions, various shunt abnormalities, and a group of miscellaneous anomalies. For injections made at a site distant from the lesion and on the right side of the circulation, the mean dose of contrast medium was 60% to 100% of the conventional dose given during standard angiography. With injections made close to the lesion and on the left side of the circulation, the mean dose of contrast medium was 27.5% to 42% of the conventional dose. Radiation exposure for each technique was markedly reduced in all age groups. A total of 92 digital subtraction angiograms were performed. Five studies were suboptimal because too little contrast medium was injected; in the remaining 87 injections, DSA and conventional studies resulted in identical diagnoses in 81 instances (p less than .001 vs chance). The remaining six injections made during DSA failed to confirm diagnoses made angiographically by standard cutfilm angiography or cineangiography. We conclude that DSA usually provides diagnostic information equivalent to that available from cutfilm angiography and cineangiography, but DSA requires considerably lower doses of contrast medium and less radiation exposure than standard conventional methods.
Reactivity of Cardiac Vessels and Reparative Processes Following Cardiac Infarction
Authors: SERGEY V. ANDREEV
Journal: Circulation (1961)

It was stated that the human heart possesses a high vasomotor activity: in 1 to 3 minutes the coronary vessels may pass into a state of spasm or dilatation in such a manner that the volume flow may change up to 2 to 7 times. Apparently, this phenomenon discloses one of the mechanisms leading to prolonged spasm of the coronary arteries. Vasomotor activity of the heart is characterized by three types of rhythmic oscillations of vessels, which differ from one another in amplitude, form, and frequency. In some intoxications (dysentery, diphtheria, pneumococcal infection) and diseases, vasomotor activity tends to decrease, whereas in the subacute stage of cardiac infarction in man and in dog, in angina pectoris, in atherosclerosis of the coronary vessels, and in hypertensive disease, it seems to be compensatorily augmented. Two-phased or distorted reaction of heart vessels is determined not only by the atherosclerotic process but by neurohumoral influences of necrotic focus upon the metabolism in the heart and in the vascular wall. The most constant spasmolytic effect upon the vessels of the human heart was obtained by the administration of euphyllin and strophathin in low concentrations. It was demonstrated that, in addition to vitamins, hormones, aminoacids, and mineral salts, many other factors participate in the regulation of vascular tone. Acceleration of reparative processes in experimentally produced focal lesions of the heart was encountered after application of a complex treatment on animals with vitamins and aminoacids (B 12 , adenosinetriphosphate, methionine, and desoxyribonucleic acid).
TUBERCULOSIS INDUCED BY DROPLET NUCLEI INFECTION
Authors: H. L. Ratcliffe, V. S. Palladino
Journal: The Journal of Experimental Medicine (1953)

Separate groups of rats, mice, hamsters, and guinea pigs were caused to inhale virulent tubercle bacilli, of human or bovine strains, as single cells in fine droplet nuclei. Members of each of these eight host-parasite combinations were killed for study at stated intervals after infection. For approximately 3 weeks after the bacilli were deposited in the lungs the progress of the infection, and the reaction of all species to it, followed a highly uniform developmental pattern. During the 4th week the rate and pattern of tubercle formation became distinctive for the species of host and the strain of parasite, but within any host-parasite combination this rate and pattern continued uniform for a time. The duration of this period of homogeneous response after the 4th week varied with the host-parasite combination, ranging from less than 5 weeks to more than 12 weeks after the induction of infection. It is concluded that the highly uniform initial response is evidence that these animals do not differ in their inherent resistance to inhaled infection by the bacilli of human or bovine tuberculosis. Instead, they differ widely in their capacity to acquire resistance to these organisms, as shown by the variation in the later stages of the disease.
Relation between Intake of Flavonoids and Risk for Coronary Heart Disease in Male Health Professionals
Authors: Eric B. Rimm
Journal: Annals of Internal Medicine (1996)

Flavonols and flavones are subgroups of flavonoids and are found in tea, vegetables, fruits, and red wine. Because they have antioxidant properties, we investigated whether intake of these dietary compounds is associated with a lower risk for fatal and nonfatal coronary heart disease.Prospective cohort study.United States.34,789 male health professionals, 40 to 75 years of age, who responded to a questionnaire in 1986.In 1986 and 1990, detailed, 131-item questionnaires were used to assess dietary intake of flavonols and flavones.Between 1986 and 1992, 496 patients received a new diagnosis of nonfatal myocardial infarction. The relative risk for nonfatal myocardial infarction was 1.08 (95% Cl, 0.81 to 1.43) for the highest (median, 40.0 mg/d) compared with the lowest (median, 7.1 mg/d) quintiles for intake of flavonols and flavones after adjustment for age, obesity, smoking, intake of vitamin E, intake of alcohol, diabetes, hypertension, hypercholesterolemia, and family history of coronary heart disease. Among the 4814 men who reported that they had previously had coronary heart disease, we found a modest but nonsignificant inverse association between intake of flavonols and flavones and subsequent coronary mortality rates (relative risk, 0.63 [Cl, 0.33 to 1.20] for the highest compared with the lowest quintile for intake of flavonoids).The data do not support a strong inverse association between intake of flavonoids and total coronary heart disease, but they do not exclude the possibility that flavonoids have a protective effect in men with established coronary heart disease.
Azithromycin for Elderly Patients With Pneumonia—Reply
Authors: Eric M. Mortensen, Carlos A. Alvarez, Ethan A. Halm
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Russia fears rapid increase in HIV infection
Authors: M. Ingram
Journal: BMJ (1997)

An explosion of HIV infection among Russia's drug misusers will spread rapidly to the general population unless urgent measures are taken, according to the United Nations AIDS office, which has recently opened in Moscow.

More than 60% of new cases of HIV recorded in 1996 were among injecting drug users, as opposed to 0.3% in 1995, when homosexual intercourse (28.6%) and medical treatment (24.5%) were the main sources of …
Diagnosis of an unusual tumor in the duodenum
Authors: C. Knackstedt, H. Wasmuth, A. Donner, C. Trautwein, R. Winograd
Journal: Endoscopy (2007)

A 65-year-old patient was admitted with repeated vomiting and suspected upper gastrointestinal bleeding. He had a known history of acute bleeding of an ulcer of the ileocoecal region, which had to be treated surgically. An esophagogastroduodenoscopy demonstrated a gastric ulcer (Forrest III; Helicobacter pylori negative), and Mallory-Weiss lesions covered with fibrin, with hemorrhagic reaction of the surrounding tissue; there was no sign of acute bleeding. Furthermore, a polyp in the duodenal bulb was seen (Figure [1]), which was considered to be of inflammatory origin. Multiple biopsies were taken.
Calcium-activated chloride current in rabbit coronary artery myocytes.
Authors: F S Lamb, K A Volk, E F Shibata
Journal: Circulation Research (1994)

Whole-cell patch-clamp techniques were used to study enzymatically dispersed epicardial coronary artery smooth muscle cells. Depolarizing voltage pulses of 500-millisecond duration from -60 mV (118 mmol/L CsCl, 22 mmol/L tetraethylammonium chloride, and 5 mmol/L EGTA pipette solution) elicited inward L-type calcium currents (ICa). When EGTA was omitted from the pipette solution, an outward current was superimposed on the calcium current, and repolarizing voltage steps produced an inward tail current (IT). The amplitude of these inward currents was proportional to the ICa amplitude from -30 to +50 mV. The time course of decay of the current was well fit by a single exponential equation. The time constant (tau) of this equation did not change with the size of IT but was clearly voltage dependent (shorter at more negative potentials). Changing the chloride reversal potential from -1.3 to -39.7 mV by anion substitution using methanesulfonate as the chloride replacement in the pipette solution shifted the zero current level of IT from 0.9 +/- 0.56 to -33.1 +/- 0.85 mV. The tail current was blocked by nifedipine (10(-6) mol/L) and by isosmolar calcium substitution with barium in the bath solution and was enhanced by the dihydropyridine agonist Bay K 8644 (10(-6) mol/L). IT was also blocked by the chloride channel blockers DIDS (10(-4) mol/L) and niflumic acid (10(-5) mol/L). Caffeine (10(-2) mol/L), which releases intracellular calcium stores, caused an inward current at holding potentials (-60 mV), which was inhibited by DIDS. Caffeine also inhibited subsequent attempts to elicit IT by depolarizing pulses (88% reduction in IT).(ABSTRACT TRUNCATED AT 250 WORDS)
Lessons learned from gene expression profiling of cutaneous T-cell lymphoma
Authors: B.O. Dulmage, L.J. Geskin
Journal: British Journal of Dermatology (2013)

Gene expression studies of cutaneous T-cell lymphoma (CTCL) span a decade, yet the pathogenesis is poorly understood and diagnosis remains a challenge. This review examines the varied approaches to gene expression analysis of CTCL, with emphasis on cell populations, control selection and expression data collection. Despite discordant results, several dysregulated genes have been identified across multiple studies, including PLS3, KIR3DL2, TWIST1 and STAT4. Here, we provide an overview of the most consistently expressed genes across different studies and bring them together through common pathways biologically relevant to CTCL. Four pathways - evasion of activation-induced cell death, T helper 2 lymphocyte differentiation, transforming growth factor-β receptor expression, and tumour necrosis factor receptor ligands - appear to encompass the most frequently affected genes, hypothetically providing insight into the disease pathogenesis.
A case of multicentric reticulohistiocytosis: uncommon clinical signs and a report of T-cell marker characteristics
Authors: C.A. GREEN, D.J. WALKER, A.J. MALCOLM
Journal: British Journal of Dermatology (1986)

Journal Article A case of multicentric reticulohistiocytosis: uncommon clinical signs and a report of T‐cell marker characteristics Get access C.A. GREEN, C.A. GREEN Departments of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K. Dr C.A. Green, Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, U.K. Search for other works by this author on: Oxford Academic Google Scholar D.J. WALKER, D.J. WALKER Departments of Rheumatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.J. MALCOLM A.J. MALCOLM Departments Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 5, 1 November 1986, Pages 623–628, https://doi.org/10.1111/j.1365-2133.1986.tb05775.x Published: 01 November 1986 Article history Accepted: 01 May 1986 Published: 01 November 1986
Developmental and inducible patterns of human θ1‐globin gene expression in embryonic/fetal and adult erythroid cells
Authors: Avgi Mamalaki, Nicholas P. Anagnou, Nicholas K. Moschonas
Journal: American Journal of Hematology (1990)

Human theta (theta 1)-globin gene represents a member of the alpha-like globin gene family residing on chromosome 16. theta 1-Specific transcripts have been detected so far only in erythroid tissues and in erythroleukemia K562 cells. To investigate systematically its inducible expression and developmental specificity, we analyzed at the RNA level five additional human erythroleukemia cell lines with diverse developmental globin programs, two somatic cell hybrids between K562 and mouse erythroleukemia (MEL) cells, a human fetal liver x MEL somatic cell hybrid, and reticulocytes and bone marrow cells from normal adults. theta 1-Globin gene was expressed in all cell types. Inducible expression (two- to sixfold) was documented both in HEL and K562 erythroleukemia cells after 5-azacytidine treatment. Like K562 cells, HEL cells also displayed hemin-inducible theta 1-globin gene expression. Following transfer of human chromosome 16 from embryonic/fetal K562 to the adult MEL cells, theta 1-globin gene remained active but lost its potential for inducibility, suggesting probably a trans regulation mechanism. Higher levels of theta 1 mRNA were found in fetal liver cells compared with trace amounts in reticulocytes and normal adult bone marrow cells. These data clearly show that in contrast to the embryonic and adult patterns of expression of zeta and alpha-globin genes, respectively, theta 1-globin gene displays a different profile, being active predominantly during the early stages of ontogeny, switching to lower levels of expression in adulthood.
Knowing Plasma Concentrations Improves Management of the Effects of Dabigatran
Authors: Claudia Stöllberger, Josef Finsterer
Journal: Journal of the American College of Cardiology (2014)

With interest we read the report by Reilly et al. [(1)][1] in a recent issue of the Journal regarding the effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in patients with atrial fibrillation. We have the following
Studies on increased vascular permeability in the pathogenesis of lesions of connective tissue diseases: I. Experimental hyperlipidaemia and immune arthropathy.
Authors: A J Valente, K W Walton
Journal: Annals of the Rheumatic Diseases (1980)

In order to investigate the known associations between hyperlipidaemia and various rheumatic complaints, immune arthritis and hyperlipidaemia have been induced concurrently in rabbits. The results obtained show that: (1) Rabbit apolipoprotein B-containing lipoproteins (LpB), which are normally virtually excluded from joint fluid, gain access to the inflamed joint in the serous effusion and serve as intrinsic indicators of altered local permeability to macromolecules. (2) Much of the LpB entering the joint space is taken up by the phagocytic cells and, following intracellular hydrolysis, leaves a lipid residue. In some chronically affected joints these residues are modified so as to give rise to crystalline cholesterol and its esters. Such crystals may serve as a chronic irritant in the joint. (3) In addition intact LpB is found sequestered in the superficial layers of intra-articular collagenous structures of the challenged joint in a distribution identical with that of similarly sequestered immune complexes and complement, suggesting altered permeability of these intra-articular structures also.
Cholesterol Metabolism in Human Obesity
Authors: Paul J. Nestel, Paul H. Schreibman, E. H. Ahrens
Journal: Journal of Clinical Investigation (1973)

An experiment was undertaken to test whether in severe obesity cholesterol production rates obtained by isotope kinetic analysis (two-pool compartmental analysis) are comparable to those measured by chemical sterol balance techniques. Eight severely obese but normocholesterolemic patients were studied by the balance method, and five of these eight were studied by compartmental analysis. Cholesterol turnover was 10% higher by compartmental analysis.
State-of-the-Art Therapeutics: Marginal-Zone Lymphoma
Authors: Francesco Bertoni, Emanuele Zucca
Journal: Journal of Clinical Oncology (2005)

Marginal-zone lymphomas comprise the mucosa-associated lymphoid tissue (MALT) type (extranodal marginal-zone lymphoma [EMZL]), the nodal marginal zone B-cell lymphoma (NMZL) and the splenic MZL (SMZL). EMZL is relatively common, whereas the remaining two entities are relatively rare disorders. EMZL, especially in its gastric localization, is the most studied MZL, and there are many data both on the underlying genetic lesions and on the role of infectious agents. These data have determined unique approach among all other lymphoma subtypes: the possibility of treating a subset of patients with antibiotics alone as first line of treatment. Indeed, there is compelling evidence that histologic regressions can be achieved in most gastric MALT lymphomas by eradicating Helicobacter pylori infection. However, molecular follow-up studies showed the persistence of the malignant clone in half of the cases in histologic remission after antibiotic treatment and transient, either histologic or molecular, relapses have been reported, too. Hence, a careful long-term follow-up is mandatory after antibiotic treatment. Radiotherapy, chemotherapy, anti-CD20 monoclonal antibodies are effective alternative therapies. The precise role of surgical resection should be redefined in view of the encouraging results of conservative approaches. Differently from EMZL, both SMLZ and NMZL often present with disseminated disease at diagnosis. The therapeutic approach comprises splenectomy, for SMZL, and chemotherapy, but with no consensus about the best treatment. This review addresses the current knowledge on the clinical features and therapeutic approaches for the individual MZLs.
UK government to appoint occupational health “tsar” to reduce work related illness
Authors: Klaus Morales
Journal: BMJ (2005)

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Intrapleural Administration of Pemetrexed: A Pharmacokinetic Study in an Animal Model
Authors: Laurent Greillier, Suzanne Monjanel-Mouterde, Anne Fraticelli, Bénédicte Devictor-Pierre, Julien Bouvenot, Nicolas Coltel, Gérald Lamarche, Philippe Astoul
Journal: Journal of Thoracic Oncology (2009)