Nifedipine, Hypotension, and Myocardial Injury
Authors: ANDREW D. LEAVITT
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 February 1988Nifedipine, Hypotension, and Myocardial InjuryANDREW D. LEAVITT, M.D., ANDREW J. ZWEIFLER, M.D.ANDREW D. LEAVITT, M.D.Search for more papers by this author, ANDREW J. ZWEIFLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-2-305 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: O'Mailia and associates (1) have reported the cases of three patients who developed hypotension and myocardial ischemia secondary to sublingual nifedipine. The following case report supports the concerns raised by these authors.A 67-year-old woman had had poorly controlled hypertension for 2 years. She had no history of rest- or exercise-related angina pectoris. She had had headache and lightheadedness, took two aspirin without relief, and went to a health clinic. At initial evaluation her vital signs included blood pressure, 260/120 mm Hg; regular pulse, 120/minute; and respiratory rate, 18/minute. She was given 10 mg of nifedipine sublingually...References1. O'MAILIASANDERGILES JGT. Nifedipine-associated myocardial ischemia or infarction in the treatment of hypertensive urgencies. Ann Intern Med. 1987;107:185-6. LinkGoogle Scholar2. HOUSTON M. Treatment of hypertensive urgencies and emergencies with nifedipine. Am Heart J. 1986;111:963-9. CrossrefMedlineGoogle Scholar1. O'MAILIASANDERGILES JCT. Nifedipine-associated myocardial ischemia or infarction in the treatment of hypertensive urgencies. Ann Intern Med. 1987;107:185-6. LinkGoogle Scholar2. BERTELCONENRADUMULLERLONGDUBACH ODEJCU. Nifedipine in hypertensive emergencies. Br Med. J. 1983;286:19-21. CrossrefMedlineGoogle Scholar3. DAVIDSONBURSTENKEELYKENNYSTEWART RSPMD. Oral nifedipine for the treatment of patients with severe hypertension. Am J Med. 1985;79(suppl 4A):26-30. CrossrefMedlineGoogle Scholar4. JENNINGSJEESMITHCOMMERFORDOPIE ALJPL. Acute effect of nifedipine on blood pressure and left ventricular ejection fraction in severely hypertensive patients. Am Heart J. 1986;111:557-63. CrossrefMedlineGoogle Scholar5. Dangerous antihypertensive treatment. Br Med J. 1979;2:228-9. CrossrefMedlineGoogle Scholar6. GUAZZIOLIVARIPOLESEFIORENTINIMAGRINIMORUZZI MMACFP. Nifedipine, a new antihypertensive with rapid action. Clin Pharmacol Ther. 1977;22:528-32. CrossrefMedlineGoogle Scholar7. HOUSTON M. Treatment of hypertensive urgencies and emergencies with nifedipine. Am Heart J. 1986;111:963-9. CrossrefMedlineGoogle Scholar1. O'MAILIASANDERGILES JGT. Nifedipine-associated myocardial ischemia or infarction in the treatment of hypertensive urgencies. Ann Intern Med. 1987;107:185-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The University of Michigan Medical Center Ann Arbor, MI 48109-0368 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Review of Calcium Channel Antagonists in the Treatment of Pediatric HypertensionAdverse events associated with aggressive treatment of increased blood pressureAdverse neurologic events associated with rebound hypertension after using short-acting nifedipine in childhood hypertensionThe calcium-channel blocker controversy: historical perspective and important lessons for future pharmacotherapies. An international society of pharmacoepidemiology ?hot topic?Reducing Inappropriate Prescribing of Sublingual NifedipineA comparison of the acute hypotensive effects of two different doses of nifedipineNifedipine and hypotensionHypertension and Stroke PreventionSurvival following severe overdose with mexiletene, nifedipine, and nitroglycerineCalcium-Channel Blockers in Acute Myocardial Infarctionβ-Adrenoceptor antagonists and antianginal drugsSI Units and Ketchup on a KilogrammerJOHN G. SOTOS, M.D. 1 February 1988Volume 108, Issue 2Page: 305-306KeywordsAnginaAspirinBlood pressureHeadachesHeart rateHypertensionHypotensionIschemiaRespiratory rateVital signs Issue Published: 1 February 1988 PDF DownloadLoading ...