Coming Catastrophes with Chloroquine?
Authors: NORMAN O. ROTHERMICH
Journal: Annals of Internal Medicine (1964)

Editorials1 December 1964Coming Catastrophes with Chloroquine?NORMAN O. ROTHERMICH, M.D., F.A.C.P.NORMAN O. ROTHERMICH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1203 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough Bagnall credits Francis Page (1) with the first observation in 1951 that quinacrine gave some relief of symptoms in rheumatoid arthritis, the use of antimalarial drugs in the treatment of this disease has become increasingly popular since Bagnall himself (2) published in 1957 the results of a 4-year study in which he obtained a "good" result in some 70% of the cases. The first warnings of hazards from this therapy began to appear soon afterwards. In 1958, Cohen and Calkins (3) in this country and Hobbs and Calnan (4) in England called attention to the possible serious visual disturbances...References1. PAGE F: Treatment of lupus erythematosus with mepacrine. Lancet 2: 755, 1951. CrossrefMedlineGoogle Scholar2. BAGNALL AW: The value of chloroquine in rheumatoid disease, a four year study of continuous therapy. Canad. Med. Ass. J. 77: 182, 1957. MedlineGoogle Scholar3. COHENCALKINS ASE: A controlled study of chloroquine as an anti-rheumatic agent. Arthritis Rheum. 1: 297, 1958. CrossrefMedlineGoogle Scholar4. HOBBSCALNAN NECD: The ocular complications of chloroquine therapy. Lancet 1: 7032, 1958. Google Scholar5. DREW JF: Concerning side effects of anti-malarial drugs used in extended treatment of rheumatic disease. Med. J. Aust. 49: 618, 1962. CrossrefGoogle Scholar6. HENKINDROTHFIELD PNF: Ocular findings in patients receiving anti-malarial therapy. Arthritis Rheum. 5: 647, 1962. Google Scholar7. SALLMANNBERNSTEIN LHN: Adverse effects of chloroquine and related anti-malarial drugs on ocular structures. Bull. Rheum. Dis. 14: 4, 1963. Google Scholar8. ZVAIFLERRUBINBERNSTEIN NJMH: Chloroquine metabolism—drug excretion and tissue deposition. Arthritis Rheum. 6: 799, 1963. Google Scholar9. HENKINDCARRSIEGEL PREI: Early chloroquine retinopathy. Arch. Ophthal. 71: 157, 1964. CrossrefMedlineGoogle Scholar10. HENKIND P: Personal communication. Google Scholar11. FREEDMANSTEINBERG AVL: Chloroquine in rheumatoid arthritis; a double blindfold trial of treatment for one year. Ann. Rheum. Dis. 19: 243, 1960. CrossrefMedlineGoogle Scholar12. SCULL E: Chloroquine and hydroxychloroquine therapy in rheumatoid arthritis. Arthritis Rheum. 5: 30, 1962. CrossrefMedlineGoogle Scholar13. POPERTMEIJERSSHARPBIER AJDAJF: Chloroquine diphosphate in rheumatoid arthritis. Ann. Rheum. Dis. 20: 18, 1961. CrossrefMedlineGoogle Scholar14. HAMILTONSCOTT EBJT: Hydroxychloroquine sulfate ("Plaquenil") in treatment of rheumatoid arthritis. Arthritis Rheum. 5: 502, 1962. CrossrefMedlineGoogle Scholar15. LA TONANORCROSS SRBM: Clinical experiences with chloroquine in rheumatoid arthritis. Arthritis Reum. 2: 80, 1959. Google Scholar16. CALKINSCOHENSHORT EAC Long-term chloroquine therapy in rheumatoid arthritis. Med. Clin. N. Amer. 45: 1219, 1961. CrossrefMedlineGoogle Scholar17. BERGLOF F: Chloroquine for arthritis (foreign mail). JAMA 179: 178, 1962. Google Scholar18. LOGANSCHMIDKRUGEROERSTOCKS CEFRSJHJW: Double-blind study of hydroxychloroquine in rheumatoid arthritis. Atti del X Congressa delta Lega Internazionale Contro il Rheumatismo 2: 1442, 1961. (As quoted by Hamilton and Scott (14)). Google Scholar19. WHISNANTESPINOSAKIERLANDLAMBERT JPRERREH: Chloroquine neuromyopathy. Proc. Mayo Clin. 38: 501, 1963. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Ohio State University College of Medicine Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEpidemiology of Hydroxychloroquine and Chloroquine RetinopathyAntimalarials in rheumatology: Efficacy and safetyOphthalmologic safety of long-term hydroxychloroquine sulfate treatmentDrug therapy (3): ‘specific’ drugsChloroquine retinopathy: is there a safe daily dose?Antimalarials and ophthalmologic safetyOphthalmologic safety of long-term hydroxychloroquine treatmentANTIRHEUMATIC THERAPYLettersAn appraisal of chloroquineAntimalarial Treatment of Rheumatoid ArthritisMöglichkeiten und Grenzen der bisherigen konservativen Therapie der Rheumatoiden ArthritisMalaria — Recent Progress and ProblemsOcular Lesions in Rheumatoid Arthritis and Related Disorders with Particular Reference to Retinopathy 1 December 1964Volume 61, Issue 6Page: 1203-1205KeywordsAntimalarialsChloroquineRheumatoid arthritis Issue Published: 1 December 1964 PDF DownloadLoading ...