tbuckley/cabot-search huggingface dataset:
CT Angiography–Fluoroscopy Fusion Imaging for Percutaneous Transapical Access
Authors: Chad Kliger, Vladimir Jelnin, Sonnit Sharma, Georgia Panagopoulos, Bryce N. Einhorn, Robert Kumar, Francisco Cuesta, Leandro Maranan, Itzhak Kronzon, Bart Carelsen, Howard Cohen, Gila Perk, Rob Van Den Boomen, Cherif Sahyoun, Carlos E. Ruiz
Journal: JACC. Cardiovascular imaging (2014)
Opening training schemes to change
Authors: S. Crowe
Journal: BMJ (2003)

We never notice the slippery slope into a comfortable rut. After medical school and internship,it is a relief to settle into a training scheme. Anaesthesia was my chosen pathway, and, after five years of anaesthesia training, I was well on my way to becoming a well rounded anaesthetist. Or so I liked to believe.

A burgeoning interest in anaesthesia for elderly patients led me to break my specialist registrar training with the intention of increasing my knowledge of general medicine and …
Prevention of Cerebral Embolization from Flushing Radial-Artery Cannulas
Authors: Edward Lowenstein, John W. Little, Hing Har Lo
Journal: New England Journal of Medicine (1971)

USE of indwelling arterial cannulas has become standard practice for monitoring of systemic arterial pressure and sampling of arterial blood in critically ill patients.1 A recent article implicates clots formed at the tip of a Scribner shunt as being responsible for cerebrovascular accidents when these clots were flushed retrograde into the central arterial circulation.2 That study included a calculation of the theoretical volume of flush solution necessary to cause cerebral embolization, but had no confirmatory measurements. The occurrence of sudden unexplained neurologic deficits in patients with indwelling radial arterial cannulas prompted the present study. The purpose was to determine a . . .
Successful ultraviolet A1 phototherapy in the treatment of localized scleroderma: a retrospective and prospective study
Authors: C. Andres, A. Kollmar, M. Mempel, R. Hein, J. Ring, B. Eberlein
Journal: British Journal of Dermatology (2009)

Ultraviolet (UV) A1 phototherapy is an effective anti-inflammatory treatment modality that influences fibroblast functions.To document the effects of UVA1 treatment in patients with localized scleroderma (LS) in a retrospective study (at least 6 months after UVA1 treatment) and in a prospective study before and immediately after medium-dose UVA1 irradiation.In total, 30 patients (retrospective study n = 17, prospective study n = 13) with LS receiving UVA1 phototherapy five times weekly (for 3-6 weeks) were investigated. Improvement was documented using standardized questionnaires and clinical evaluation (using modified Rodnan skin score, Cutometer and 7.5-MHz ultrasound measurements). Levels of collagen I and collagen III metabolites were measured in serum and urine.In the retrospective study, medium-dose UVA1 phototherapy had been performed 6 months-3 years earlier (cumulative dose 750-1400 J cm(-2); mean + or - SD number of irradiations 19.3 + or - 3.8). Fourteen of 17 patients (82%) reported an improvement in symptoms following UVA1 therapy. In the prospective study, skin elasticity increased in 77% of the patients following medium-dose UVA1 phototherapy (cumulative dose 750-1250 J cm(-2); mean + or - SD number of irradiations 20.8 + or - 4.0). 7.5-MHz ultrasound measurements showed a mean reduction of lesional skin thickness of 13% compared with skin thickness before UVA1 phototherapy. The ratio of deoxypyridinoline to creatinine was significantly elevated in about two-thirds of the patients.This open study showed a positive short- and long-term efficacy of UVA1 phototherapy in patients with LS, with a reduction in sclerotic plaques, an increase in skin elasticity and a reduction of lesional skin thickness. UVA1 phototherapy had a significant effect on collagen metabolism. UVA1 phototherapy can be regarded as a safe treatment modality for patients with LS.
ACANTHOMATA APPEARING AFTER ECZEMA.
Authors: MURRAY G. WILLIAMS
Journal: British Journal of Dermatology (1956)

Journal Article ACANTHOMATA APPEARING AFTER ECZEMA. Get access MURRAY G. WILLIAMS, M.D. MURRAY G. WILLIAMS, M.D. Registrar, St. John's Hospital for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 68, Issue 7-8, 1 July 1956, Pages 268–271, https://doi.org/10.1111/j.1365-2133.1956.tb12815.x Published: 01 July 1956
Low-Molecular-Weight Heparin — An Opportunity for Home Treatment of Venous Thrombosis
Authors: Andrew I. Schafer
Journal: New England Journal of Medicine (1996)

Venous thromboembolism, a disease now recognized in most cases to have a genetic basis,1 is the discharge diagnosis of more than a quarter-million patients in U.S. hospitals annually.2 Heparin has been the standard initial therapy for this condition since the 1940s. For many years, evidence of the efficacy of heparin in these patients was based on experimental studies in animals and uncontrolled clinical experience. Not until 1992 did a randomized, double-blind trial demonstrate that patients with deep-vein thrombosis do indeed require initial treatment with full-dose heparin.3 Admission to the hospital has been deemed necessary for patients with deep-vein thrombosis in . . .
A Will and a Way: What the United States Can Learn From Canada About Caring for the Elderly
Authors: Mal Schechter
Journal: JAMA (1986)

The marriage of geriatrics and social insurance is thriving in Canada and is stymied in the United States. All of the difficulties cited and recited for an American program of medical and social care, including prevention and long-term community as well as nursing-home service, are being solved in the three Canadian provinces investigated by Robert L. Kane, a physician, and Rosalie A. Kane, a social work specialist, in<i>A Will and a Way: What the United States Can Learn From Canada About Caring for the Elderly</i>. There is plenty to be learned conceptually and operationally about utilization, service coordination, case management, quality, client satisfaction, and the spirit of the provincial programs. In short, the book deals with documented experience of regular programs, not temporary demonstrations. Everyone who grapples with the issues—from professionals and business people to patients and families— will profit from this perceptive, readable, and judicious book. The Kanes
Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia
Authors: Michael Quante, Govind Bhagat, Julian A. Abrams, Frederic Marache, Pamela Good, Michele D. Lee, Yoomi Lee, Richard Friedman, Samuel Asfaha, Zinaida Dubeykovskaya, Umar Mahmood, Jose-Luiz Figueiredo, Jan Kitajewski, Carrie Shawber, Charles J. Lightdale, Anil K. Rustgi, Timothy C. Wang
Journal: Cancer Cell (2012)
Benefit of Prophylactic Mastectomy for Women With BRCA1 or BRCA2 Mutations
Authors: L.-A. Miller
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction treatment of chronic hepatitis C with daily interferon plus ribavirin plus amantadine is effective in non-responders to interferon plus ribavirin
Authors: R. Stauber, P. Munda-Steindl, F. Hackl, K. Schüutze, C. Datz, H. Hofer, K. Hegenbarth, W. Jessner, P. Ferenci
Journal: Journal of Hepatology (2001)
PREVENTION OF CONTRAST–INDUCED NEPHROPATHY IN PATIENTS WITH RENAL INSUFFICIENCY WITH STEMI
Authors: Per Thayssen, Jens F. Lassen, Svend Eggert Jensen, Knud Noerregaard Hansen, Henrik Steen Hansen, Evald H. Christiansen, Anders Junker, Jan Ravkilde, Leif Thuesen, Karsten T. Veien, Lisette Okkels Jensen
Journal: Journal of the American College of Cardiology (2013)
Genotypic diversity of imipenem resistant isolates of Acinetobacter baumannii in Spain
Authors: Jesús Oteo, Carmen García-Estébanez, Silvia Migueláñez, José Campos, Sara Martí, Jordi Vila, Ma Ángeles Domínguez, Fernando Docobo, Nieves Larrosa, Álvaro Pascual, Vicente Pintado, Pere Coll
Journal: Journal of Infection (2007)
Cardiac Magnetic Resonance Versus Routine Cardiac Catheterization Before Bidirectional Glenn Anastomosis in Infants With Functional Single Ventricle
Authors: David W. Brown, Kimberlee Gauvreau, Andrew J. Powell, Peter Lang, Steven D. Colan, Pedro J. del Nido, Kirsten C. Odegard, Tal Geva
Journal: Circulation (2007)

Routine preoperative catheterization is standard practice in patients with single-ventricle physiology before bidirectional Glenn anastomosis. Because catheterization is invasive and exposes patients to ionizing radiation, cardiac magnetic resonance (CMR) may be a safe and effective alternative.We conducted a prospective, randomized, single-center clinical trial comparing catheterization with CMR in patients considered for bidirectional Glenn operation from February 2003 to June 2006. End points were frequency of adverse events of the preoperative evaluation and a composite score of clinically successful surgery. Of 92 eligible patients, 82 were enrolled on the basis of screening echocardiogram, fulfillment of inclusion criteria, and informed consent. Patients were randomized to catheterization (n=41) or CMR (n=41). There were no baseline differences between groups. Four treatment crossovers occurred, 3 to catheterization and 1 to CMR. Catheter interventions were performed in 17 patients (41%). Catheterization resulted in more minor adverse events (78% versus 5%; P<0.001), longer preoperative hospital stays (median, 2 versus 1 day; P<0.001), and higher hospital charges ($34 477 versus $14 921; P<0.001). There was 1 major adverse event in the CMR group (P=1.0). The operative course and frequency of postoperative complications were similar between the 2 groups. The proportion of patients who had a successful bidirectional Glenn operation was similar (71% versus 83%; P=0.3). At the 3-month follow-up, there were no differences in clinical status, oxygen saturation, or frequency of reinterventions.CMR is a safe, effective, and less costly alternative to routine catheterization in the evaluation of selected patients before bidirectional Glenn operation. Further studies are necessary to determine whether there are long-term benefits from transcatheter interventions in these patients.
TRANSCATHETER AORTIC VALVE IMPLANTATION IN PATIENTS WITH AN ANNULUS OF INTERMEDIATE SIZE TREATABLE WITH EITHER THE EDWARDS VALVE OR THE COREVALVE
Authors: Yusuke Watanabe, Kentaro Hayashida, Masanori Yamamoto, Gauthier Mouillet, Bernard Chevalier, Atsushi Oguri, Jean–Luc Dubois–Rande, Marie–Claude Morice, Emmanuel Teiger, Thierry Lefèvre
Journal: Journal of the American College of Cardiology (2013)
DISTINCT COPY NUMBER ALTERATIONS AND INCIDENCE OF CHROMOTHRIPSIS ASSOCIATED WITH GRADE AND PROGNOSIS IN IDH MUTANT AND WILD-TYPE GLIOMAS
Authors: H. Colman, A. Cohen, K. Aldape, M. Sato, C. Mason, K. Diefes, L. Heathcock, L. Abegglen, D. Shrieve, W. Couldwell, J. Schiffman
Journal: Neuro-Oncology (2014)

BACKGROUND: Both IDH mutated (IDHmut) and wild-type (IDHwt) lower grade gliomas can progress to GBM. However, a detailed study of alterations associated with progression of these molecularly distinct tumor types has not been described. Here we perform an analysis of copy number alterations (CNA) across all grades (Grade II-II and Grade IV) IDHmut vs IDHwt infiltrating gliomas. METHODS: DNA was extracted from 94 patient FFPE glioma samples from 4 clinical and molecular groups: Grade II-III IDHwt (n = 17), Grade II-III IDHmut (n = 28), Grade IV IDHwt (n = 25), and Grade IV IDHmut (n = 24). CNA were detected by molecular inversion probes (OncoScan FFPE Express, Affymetrix) and analyzed with Nexus Copy Number Software (BioDiscovery). GISTIC was used to define deletions and amplifications. Chromothripsis (“chromosomal shattering”) was defined using stringent criteria of at least ten switches of CNA in individual chromosomes. RESULTS: Unsupervised clustering of CNAs demonstrated distinct clusters within IDHmut gliomas that correlated with grade. However, within IDHwt gliomas all grades clustered together regardless of grade, with Chr7 amplification (including EGFR) and loss of Chr10 (including PTEN) seen in most tumors. IDHwt Grade II-III and Grade IV tumors both displayed relatively poor prognosis (median survivals of 65.4 and 37.4 weeks). However, IDHmut gliomas had better survival for all grades (604.3 weeks for Grade II-III and 270.3 weeks for Grade IV). Grade IV IDHmut gliomas were more likely to have gains of 1q25.3 (SMG7, NCF2), 1q32.1 (KIF14, DDX59, BTG2), 6p21.1 (HSP90AB1 and other genes) and loss of 3p21 compared with Grade II-III. Functional analyses showed that IDHwt tumors had more amplifications in receptor tyrosine kinases and their downstream pathways. In terms of novel prognostic markers within IDHmut Grade II-III tumors, multivariate analysis identified loss of estrogen receptor B and loss of 10q26.3 containing part of GLRX3 as poor prognostic factors, and CDKN1C loss as a good prognostic factor. Finally, significantly higher incidence of chromothripsis events were observed in grade IV IDHmut compared to IDHwt. CONCLUSIONS: CNA analysis demonstrated significant differences in molecular ontogeny, progression, and prognosis between IDHwt and IDHmut gliomas, which may serve to further elucidate pathogenesis of these distinct tumor types. Significant CNA increases and increased chromothripsis in grade IV IDHmut support malignant transformation of IDHmut low grade gliomas through accumulation of genomic instability, that results later in partial overlap of CNA alterations that are seen earlier in the development of IDHwt tumors. SECONDARY CATEGORY: Tumor Biology.
Argon plasma coagulation offers survival benefit compared with stent placement in the palliative treatment of inoperable oesophageal cancer; a retrospective single centre experience
Authors: C. Krystallis, S. Paterson-Brown, J. N. Plevris
Journal: Gut (2011)

<h3>Introduction</h3> Over 2/3 of patients diagnosed with oesophageal cancer (Ca) are not surgical candidates and require palliative treatment. Endoscopic therapy with self expanding metal stents (SEMS) or thermal ablative techniques (laser, APC) are commonly used for palliation. Although SEMS have no direct effect on tumour growth, they improve clinical condition by improving nutritional status, and by preventing dehydration and aspiration. A randomised trial comparing laser with metal stent for palliation of oesophageal Ca, demonstrated significantly longer survival in the thermal tumour ablation group a few years ago. APC is considered an effective palliative treatment for debulking exophytic oesophageal tumours, and is associated with clinical improvement of tumour-related symptoms including dysphagia and anaemia. However it is not known whether APC is associated with improved survival compared with SEMS, in patients who are not candidates for surgery or chemo-radiotherapy (CRT). The study aim was to compare survival of patients with inoperable Ca of the oesophagus who received APC versus SEMS as primary treatment. <h3>Methods</h3> Retrospective study of 209 patients retrieved from endoscopy database with inoperable ca of the oesophagus/oesophago-gastric junction extending to the oesophagus, who received palliative treatment with APC (Group A) or SEMS (Group B) over a 10-year period. We excluded 56 patients received CRT before or after APC/stent placement. All cases were discussed at local multidisciplinary meeting and details about co-morbidity (Charlson co-morbidity index) and tumour staging were available in all patients studied. Kaplan-Meir survival curves and log-rank median survival comparisons were carried out between the two groups matched by disease stage. <h3>Results</h3> From a total of 153 patients, APC (on intention to treat) was given to 61 (Group A) and stents to 92 patients (Group B) respectively. Mean age and gender (M/F) (76.55, 42/19 vs 76.28, 59/33) in group A and B respectively. The comparisons of median survivals between groups overall and subgroups of same disease stage are: Group A versus B overall 275 days ± 22.3 versus 112 ±17.58 (log rank p&lt;0.0001), stage III-IV disease 241 days±24.5 versus 110±15.9 (log rank p&lt;0.0001), stage III disease 300 days±28.62 versus 147±6.08 (log rank p&lt;0.0001). All groups in comparison had no differences in comorbidity. <h3>Conclusion</h3> This the first evidence that APC prolongs survival in patients not candidates for surgery or CRT compared with stenting. Stenting should be reserved for cases that APC can no longer maintain lumen patency. Further prospective evaluation is worthy.
Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis
Authors: Patricia Cortazar, Lijun Zhang, Michael Untch, Keyur Mehta, Joseph P Costantino, Norman Wolmark, Hervé Bonnefoi, David Cameron, Luca Gianni, Pinuccia Valagussa, Sandra M Swain, Tatiana Prowell, Sibylle Loibl, D Lawrence Wickerham, Jan Bogaerts, Jose Baselga, Charles Perou, Gideon Blumenthal, Jens Blohmer, Eleftherios P Mamounas, Jonas Bergh, Vladimir Semiglazov, Robert Justice, Holger Eidtmann, Soonmyung Paik, Martine Piccart, Rajeshwari Sridhara, Peter A Fasching, Leen Slaets, Shenghui Tang, Bernd Gerber, Charles E Geyer, Richard Pazdur, Nina Ditsch, Priya Rastogi, Wolfgang Eiermann, Gunter von Minckwitz
Journal: The Lancet (2014)
Recovery from Broken Neck.
Authors: Frank M. Sherman
Journal: JAMA (1907)

West Newton, Mass., June 12, 1907. <h3>To the Editor:</h3> —The article by Arthur Ayer Law, M.D., inThe Journal, June 8, 1907, is entitled "Recovery from Broken Neck." There is nothing in the history of the case reported which is incompatible with the assumption that it was really a bilateral forward dislocation, without fracture. The statements with which Dr. Law supports his diagnosis of fracture viz.: "that the conclusions of practically all observers have been that dislocation of the cervical vertebræ without some fracture is impossible," and that "the articular processes are placed nearly vertical," are erroneous. Practically all observers have concluded that dislocation of the cervical vertebræ, without fracture,<i>does</i>occur. For example, Stephen Smith says: "In the cervical region forward and backward luxations may occur with or without fracture." Scudder says: "A dislocation without fracture may occur in the cervical region; it is rare in other regions of
Looking for Betty
Authors: Jaime E. Ollé-Goig
Journal: Annals of Internal Medicine (2005)

On Being a Doctor15 November 2005Looking for BettyJaime E. Ollé-Goig, MD, MPHJaime E. Ollé-Goig, MD, MPHFrom St. Francis Hospital, Buluba, Uganda.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-10-200511150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Mothers line the corridor of the pediatric ward of our rural hospital in Uganda, holding up their babies and waiting for the physician to begin their visit. The lowering of hospitalization fees has had a major impact on our already overburdened daily work. As I try to find a passage through the crowd, I notice a woman holding a young girl who is obviously very sick. A few questions and a brief physical examination make me think that the girl—her niece, Betty—suffers from meningitis. The lumbar puncture reveals cloudy spinal fluid, and the laboratory results suggest tuberculosis. I start her ... Author, Article, and Disclosure InformationAffiliations: From St. Francis Hospital, Buluba, Uganda.Corresponding Author: Jaime E. Ollé-Goig, MD, MPH, Carretera de las Aguas 181, 08017 Barcelona, Spain; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byÚltimas historias ugandesas o el triunfo de Mamadi 15 November 2005Volume 143, Issue 10Page: 755KeywordsChildrenForecastingHipHospitalizationsMeningitisResearch laboratoriesRiversStreptomycinTemperature ePublished: 15 November 2005 Issue Published: 15 November 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sweat secretion, stratum corneum hydration, small nerve function and pruritus in patients with advanced chronic renal failure
Authors: G. YOSIPOVITCH, J. REIS, E. TUR, E. SPRECHER, D. YARNITSKY, G. BONER
Journal: British Journal of Dermatology (1995)

Sweat secretion, stratum corneum hydration and small nerve fibre function were measured in 40 patients with advanced chronic renal failure (CRF), using pilocarpine iontophoresis, electrical capacitance and a thermal sensory analyser which measures the thresholds of warm and heat pain sensation. Correlations were sought between these parameters, and the presence and severity of pruritus and skin xerosis were compared with 45 healthy control subjects. The mean sweat secretion and stratum corneum hydration of CRF patients were significantly lower than in controls. Thirteen patients had pathological thresholds to warm sensation on the foot, and eight on the hand. None had pathological thresholds to heat-pain. The presence of pruritus did not correlate with any of the following: xerosis, stratum corneum hydration, sweat secretion or the results of thermal testing.
One Last Teaching Moment
Authors: H. Esterbrook Longmaid
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mediastinal mass caused by syphilitic aortitis.
Authors: R Hofmann-Wellenhof, W Domej, C Schmid, D Rossmann-Moore, P Kullnig, M Annelli-Monti
Journal: Thorax (1993)

A 47 year old man presented with hoarseness and chest pain found to be due to proliferative syphilitic aortitis. The case is unusual as the syphilitic aortitis caused a mediastinal mass without affecting the lumen of the aorta.