tbuckley/cabot-search huggingface dataset:
Prevalence of Carotid Atherosclerosis in Diabetic Patients Ultrasound high-resolution B-mode imaging on carotid arteries
Authors: Ryuzo Kawamori, Yamasaki Yamasaki, Hiroyuki Matsushima, Hideko Nishizawa, Katsunori Nao, Hougaku Hougaku, Hiroaki Maeda, Nobuo Handa, Masayasu Matsumoto, Takenobu Kamada
Journal: Diabetes Care (1992)

To quantitatively assess atherosclerosis of the carotid artery in subjects with and without diabetes.Ultrasound high resolution B-mode imaging of carotid arteries was conducted on 71 nondiabetic subjects without hyperlipidemia or hypertension and 295 diabetic patients to determine IMT of the arterial wall.IMT was linearly related with age in nondiabetic (IMT = [0.0087 x age] + 0.3318) and diabetic subjects (IMT = [0.0155 x age] + 0.32450). The regression coefficient for age was significantly greater in diabetic than nondiabetic subjects. IMT (mean +/- SD) of diabetic subjects aged 20-29 was significantly greater than that of nondiabetic subjects aged 20-29 (0.73 +/- 0.27 vs. 0.52 +/- 0.07 mm, P less than 0.01). Multivariate regression analysis of 275 NIDDM patients indicated smoking, hyperlipidemia, duration of diabetes, hypertension, and age were factors determining thickness of the carotid arterial wall.Diabetes, along with age, hyperlipidemia, smoking, and hypertension, aggravates carotid atherosclerosis.
Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery
Authors: Helen O. McCarthy, Joanne McCaffrey, Cian M. McCrudden, Aleksey Zholobenko, Ahlam A. Ali, John W. McBride, Ashley S. Massey, Sreekanth Pentlavalli, Kun-Hung Chen, Grace Cole, Stephen P. Loughran, Nicholas J. Dunne, Ryan F. Donnelly, Victoria L. Kett, Tracy Robson
Journal: Journal of Controlled Release (2014)
Efficient species C HAdV infectivity in plasmocytic cell lines using a clathrin-independent lipid raft/caveola endocytic route
Authors: Morvane Colin, L. Mailly, S. Rogée, Jean-Claude D'Halluin
Journal: Molecular Therapy (2004)

Hematopoietic cells are known to be refractory to species C human adenovirus (HAdV) infection; however, the reason for this has not been clearly established. We have previously demonstrated that this nonpermissivity is the consequence of inefficient HAdV particle uptake, notably in B lymphocytes. We noted that while the protein clathrin is observed in association with membranes in epithelial cells, it is found predominantly in the cytoplasm of hematopoietic cell lines. So it appears that altered clathrin-coated pit endocytosis could explain the weak HAdV uptake in B cells. In contrast, mature B cell plasmocytes are permissive to HAdV. However, this is not the result of clathrin-coated pit endocytosis since this process is also inefficient in these cells. Confocal microscopy showed colocalization between HAdV particles and caveolae/lipid rafts in plasmocytes. Moreover, inhibiting caveola endocytosis by depletion of cholesterol or expression of dominant negative caveolin-1 in these cells results in a 50-70% reduction in HAdV infectivity. It appears that caveola endocytosis and nonclathrin noncaveola endocytosis are used by HAdV to enter plasmocytes in response to a loss of the clathrin-dependent pathway. Thus targeting of caveolae by modifying the capsid of HAdV may represent an alternative approach to enhancing uptake in most hematopoietic cells for future gene therapy.
Efalizumab-induced autoimmune pancytopenia
Authors: W.L. Tom, M.D. Miller, M.Y. Hurley, T. Suneja, G. Kudva, C.L. Leonardi, J.M. Obadiah
Journal: British Journal of Dermatology (2006)

Journal Article Efalizumab‐induced autoimmune pancytopenia Get access W.L. Tom, W.L. Tom Department of Dermatology and Division of Hematology and Oncology, Department of Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar M.D. Miller, M.D. Miller Department of Dermatology and Division of Hematology and Oncology, Department of Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar M.Y. Hurley, M.Y. Hurley Department of Dermatology and Division of Hematology and Oncology, Department of Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar T. Suneja, T. Suneja Department of Dermatology and Division of Hematology and Oncology, Department of Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar G. Kudva, G. Kudva Department of Dermatology and Division of Hematology and Oncology, Department of Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar C.L. Leonardi, C.L. Leonardi Department of Dermatology and Division of Hematology and Oncology, Department of Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, U.S.A Search for other works by this author on: Oxford Academic Google Scholar J.M. Obadiah J.M. Obadiah Department of Dermatology and Division of Hematology and Oncology, Department of Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, U.S.A Joseph M. Obadiah. E‐mail: obadiahj@slucare1.sluh.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 5, 1 November 2006, Pages 1045–1047, https://doi.org/10.1111/j.1365-2133.2006.07437.x Published: 01 November 2006 Article history Accepted: 03 May 2006 Published: 01 November 2006
US Senate considers proposal to tighten drug patent law
Authors: D. Josefson
Journal: BMJ (2002)

The US Senate is considering a bill to close a loophole in the drug patent laws that has enabled drugs companies to get easy and frequent extensions of 30 months to their patents.

The hotly debated new Greater Access to Pharmaceuticals Bill, also known as the McCain-Schumer bill after the senators who sponsored it, seeks to reform an earlier law, the Waxman-Hatch Act of 1984. This law sought to foster price competition while preserving patent rights.

The Waxman-Hatch Act allows manufacturers to file applications for generic equivalents …
Maraba MG1 Virus Enhances Natural Killer Cell Function via Conventional Dendritic Cells to Reduce Postoperative Metastatic Disease
Authors: Jiqing Zhang, Lee-Hwa Tai, Carolina S Ilkow, Almohanad A Alkayyal, Abhirami A Ananth, Christiano Tanese de Souza, Jiahu Wang, Shalini Sahi, Lundi Ly, Charles Lefebvre, Theresa J Falls, Kyle B Stephenson, Ahmad B Mahmoud, Andrew P Makrigiannis, Brian D Lichty, John C Bell, David F Stojdl, Rebecca C Auer
Journal: Molecular Therapy (2014)

This study characterizes the ability of novel oncolytic rhabdoviruses (Maraba MG1) to boost natural killer (NK) cell activity. Our results demonstrate that MG1 activates NK cells via direct infection and maturation of conventional dendritic cells. Using NK depletion and conventional dendritic cells ablation studies in vivo, we established that both are required for MG1 efficacy. We further explored the efficacy of attenuated MG1 (nonreplicating MG1-UV(2min) and single-cycle replicating MG1-Gless) and demonstrated that these viruses activate conventional dendritic cells, although to a lesser extent than live MG1. This translates to equivalent abilities to remove tumor metastases only at the highest viral doses of attenuated MG1. In tandem, we characterized the antitumor ability of NK cells following preoperative administration of live and attenuated MG1. Our results demonstrates that a similar level of NK activation and reduction in postoperative tumor metastases was achieved with equivalent high viral doses concluding that viral replication is important, but not necessary for NK activation. Biochemical characterization of a panel of UV-inactivated MG1 (2-120 minutes) revealed that intact viral particle and target cell recognition are essential for NK cell-mediated antitumor responses. These findings provide mechanistic insight and preclinical rationale for safe perioperative virotherapy to effectively reduce metastatic disease following cancer surgery.
THE GALVANIC CURRENT FOR THE TREATMENT OF PTERYGIUM.
Authors: HORACE M. STARKEY
Journal: JAMA (1898)

Since electricity has been used in almost every diseased condition of the eye and its appendages, from senile cataract to stricture of the nasal duct, a brief enumeration only of these various uses would consume all the time allowed. This will not be attempted, but attention will be confined to the use of electricity in one condition—pterygium. Six years ago at the Detroit meeting of this Section, the writer made a brief statement concerning the treatment of pterygium with a weak galvanic current, which he had been employing with apparently good results for about two years, and requested members of the Section to give the method a trial. While he is not aware that that request has met with any response, he has continued to employ the method then outlined, and longer experience has convinced him that it has decided value in suitable cases. In September, 1889, the writer, who
Cooling Detection Thresholds in the Assessment of Diabetic Sensory Polyneuropathy
Authors: Lorne H. Zinman, Vera Bril, Bruce A. Perkins
Journal: Diabetes Care (2004)

OBJECTIVE—Cooling detection threshold testing may be an important quantitative method for assessing polyneuropathy, in that it has traditionally been viewed as a measure of small-fiber involvement. The present study sought to determine the agreement between two common testing devices and to determine whether these are concordant in their association with predictor variables for diabetic sensory polyneuropathy. RESEARCH DESIGN AND METHODS—A total of 83 patients with diabetes (10 patients with type 1 diabetes and 73 patients with type 2 diabetes) and a wide spectrum of diabetic sensory polyneuropathy severity underwent concurrent cooling detection threshold testing using the Medoc and CASE IV instruments. Common predictor variables for diabetic sensory polyneuropathy were measured on the same day. RESULTS—Measurements of cooling detection thresholds by both instruments were highly correlated (Spearman’s correlation coefficient 0.81, P &amp;lt; 0.001) and demonstrated a high degree of agreement by the method of Bland and Altman (95% distribution critical values for the difference in cooling detection thresholds, +7.5 and −5.6°C). Cooling detection thresholds by both instruments were strongly correlated with clinical indicators of large-fiber neuropathy but not with the symptoms of small-fiber neuropathy (pain). CONCLUSIONS—These two instruments available for assessment of cooling detection thresholds are interchangeable for research in diabetic sensory polyneuropathy. However, this modality is equivalent to other modalities of quantitative sensory threshold testing in its association with indicators of large-fiber neuropathy and does not seem to provide an advantage for the prediction of small-fiber involvement.
The Course of Disability Before and After a Serious Fall Injury
Authors: Thomas M. Gill, Terrence E. Murphy, Evelyne A. Gahbauer, Heather G. Allore
Journal: JAMA Internal Medicine (2013)

<h3>Importance</h3> Although a serious fall injury is often a devastating event, little is known about the course of disability (ie, functional trajectories) before a serious fall injury or the relationship between these trajectories and those that follow the fall. <h3>Objectives</h3> To identify distinct sets of functional trajectories in the year immediately before and after a serious fall injury, to evaluate the relationship between the prefall and postfall trajectories, and to determine whether these results differed based on the type of injury. <h3>Design, Setting, and Participants</h3> Prospective cohort study conducted in greater New Haven, Connecticut, from March 16, 1998, to June 30, 2012, in 754 community-living persons aged 70 years or older who were initially nondisabled in their basic activities of daily living. Of the 130 participants who subsequently sustained a serious fall injury, 62 had a hip fracture and 68 had another fall-related injury leading to hospitalization. <h3>Main Outcomes and Measures</h3> Functional trajectories, based on 13 basic, instrumental, and mobility activities assessed during monthly interviews, were identified in the year before and the year after the serious fall injury. <h3>Results</h3> Before the fall, 5 distinct trajectories were identified: no disability in 16 participants (12.3%), mild disability in 34 (26.2%), moderate disability in 34 (26.2%), progressive disability in 23 (17.7%), and severe disability in 23 (17.7%). After the fall, 4 distinct trajectories were identified: rapid recovery in 12 participants (9.2%), gradual recovery in 35 (26.9%), little recovery in 26 (20.0%), and no recovery in 57 (43.8%). For both hip fractures and other serious fall injuries, the probabilities of the postfall trajectories were greatly influenced by the prefall trajectories, such that rapid recovery was observed only among persons who had no disability or mild disability, and a substantive recovery, defined as rapid or gradual, was highly unlikely among those who had progressive or severe disability. The postfall trajectories were consistently worse for hip fractures than for the other serious injuries. <h3>Conclusions and Relevance</h3> The functional trajectories before and after a serious fall injury are quite varied but highly interconnected, suggesting that the likelihood of recovery is greatly constrained by the prefall trajectory.
Does the Endoscope Control Head Need to be Disinfected between Examinations?
Authors: G. M. Sobala, C. Lincoln, A. T. R. Axon
Journal: Endoscopy (1989)

An evaluation was made of the incidence of contamination of endoscope control heads during gastroduodenoscopy and colonoscopy, and of the efficacy of a simple disinfection technique. Contamination of the control heads occurred in 4 out of 17 examinations. Scrubbing in detergent followed by wiping with swabs impregnated with 70% isopropyl alcohol and 2% chlorhexidine achieved adequate disinfection of artificial heavy contamination of the control head. The endoscope control head represents a potential source of cross-infection and should not be neglected in any cleaning procedure.
THE AGE DISTRIBUTION OF COMMON SKIN DISORDERS IN THE BANTU OF PRETORIA, TRANSVAAL
Authors: R. G. PARK
Journal: British Journal of Dermatology (1968)

Journal Article THE AGE DISTRIBUTION OF COMMON SKIN DISORDERS IN THE BANTU OF PRETORIA, TRANSVAAL Get access R. G. PARK R. G. PARK Section of Dermatology, University of Pretoria, Pretoria, S. Africa Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 11, 1 November 1968, Pages 758–759, https://doi.org/10.1111/j.1365-2133.1968.tb11941.x Published: 01 November 1968 Article history Accepted: 25 April 1968 Published: 01 November 1968
GW25-e1409 CKIP-1 can regulate physiological cardiac hypertrophy through inhibition of HDAC4 phosphorylation
Authors: Ling Shukuan, Zhang Pengfei, Li Yuheng, Zhao Dingsheng, Sun Weijia, Xu Zi, Zhong Guohui, Li Qi, Song Jinping, Li Yinghui, Li Yingxian
Journal: Journal of the American College of Cardiology (2014)
Ischemic preconditioning preserves creatine phosphate and intracellular pH.
Authors: M Kida, H Fujiwara, M Ishida, C Kawai, M Ohura, I Miura, Y Yabuuchi
Journal: Circulation (1991)

Ischemic preconditioning slows ATP depletion and ultrastructural damage during the final episode of ischemia. To define the influence of creatine phosphate (CP) and intracellular pH (pHi) on this effect, CP and pHi were serially measured in porcine hearts without collateral circulation by using 31P-NMR spectroscopy and ultrastructural examination.Farm pigs weighing 12-15 kg were anesthetized with Fluothane. The control group underwent a single occlusion (20 minutes or 60 minutes); the preconditioned group underwent four episodes of 5-minute occlusion and 5-minute reperfusion followed by a sustained occlusion (20 minutes or 60 minutes). After ischemic preconditioning, CP increased to 115 +/- 11% (p less than 0.05) of preischemic value and ATP decreased to 84 +/- 8% (p less than 0.05) of preischemic value, but pHi returned to preischemic value. At 5 and 10 minutes of sustained ischemia, CP was significantly preserved in the preconditioned group (control group, 19 +/- 3% versus preconditioned group, 29 +/- 4% at 5 minutes; control group, 5 +/- 3% versus preconditioned group, 11 +/- 3% at 10 minutes; p less than 0.05). At 15 and 20 minutes of sustained ischemia, ATP was significantly preserved in the preconditioned group (control group, 64 +/- 3% versus preconditioned group, 73 +/- 3% at 15 minutes; control group, 51 +/- 7% versus preconditioned group, 62 +/- 2% at 20 minutes; p less than 0.05). At 10, 15, 20, and 25 minutes of sustained ischemia, pHi was significantly higher in the preconditioned group (control group, 6.5 +/- 0.05 versus preconditioned group, 6.7 +/- 0.1 at 10 minutes; control group, 6.3 +/- 0.05 versus preconditioned group, 6.6 +/- 0.06 at 15 minutes; control group, 6.1 +/- 0.1 versus preconditioned group, 6.4 +/- 0.1 at 20 minutes; control group, 6.0 +/- 0.2 versus preconditioned group, 6.3 +/- 0.1 at 25 minutes; p less than 0.05). Ultrastructural changes were milder in the preconditioned group at 20 minutes of sustained ischemia.In addition to ATP and ultrastructure, preconditioning preserved CP and pHi during sustained ischemia. These protective effects might be due to overshoot phenomenon of CP and/or reduced ATP consumption. The relatively longer period of preservation of pHi, which probably is the result of reduced ATP consumption, indicates its greater contribution to reducing infarct size than that of CP and ATP.
Effect of Hypoglycemia on Brain Structure in People With Type 2 Diabetes: Epidemiological Analysis of the ACCORD-MIND MRI Trial
Authors: Zi Zhang, James Lovato, Harsha Battapady, Christos Davatzikos, Hertzel C. Gerstein, Faramarz Ismail-Beigi, Lenore J. Launer, Anne Murray, Zubin Punthakee, Amilcar A. Tirado, Jeff Williamson, R. Nick Bryan, Michael E. Miller
Journal: Diabetes Care (2014)

The effect of hypoglycemia related to treatment of type 2 diabetes mellitus (T2DM) on brain structure remains unclear. We aimed to assess whether symptomatic severe hypoglycemia is associated with brain atrophy and/or white matter abnormalities.
Redeployments Strain Military Families
Authors: Lynne Lamberg
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Intervertebral Disc and Its Surrounding Tissues
Authors: Wallace B. Hamby
Journal: JAMA (1961)

This book assembles many data bearing upon the problem of intervertebral disc disease, and it will make good reading for all interested in the entity. It is produced in handsome style with excellent engravings and with colored plates of histologic preparations made with a stain developed by the author. The author believes that a systemic disease is the cause of symptom-producing alterations of the intervertebral disc. The study leading to the writing of the book was undertaken in an effort to support this hypothesis. The author gives an excellent review of the anatomy and histology of the disc. In discussing nerve root zones of anchorage and their role in pain production by disc protrusions, he says, "Hence, the cervical discs should be less prone to displacement than discs at lower levels. But this is not so." No basis is given for this statement, yet certainly it is true at the
Medical Strikes in mFrance
Authors: Gérard Drobinski, Daniel Thomas, Yves Grosgogeat, Richard F. Leighton
Journal: Annals of Internal Medicine (1983)

Abroad1 December 1983Medical Strikes in mFranceGÉRARD DROBINSKI, M.D., DANIEL THOMAS, M.D., YVES GROSGOGEAT, M.D., RICHARD F. LEIGHTON, M.D.GÉRARD DROBINSKI, M.D., DANIEL THOMAS, M.D., YVES GROSGOGEAT, M.D., RICHARD F. LEIGHTON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-6-862 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe ferment in French medicine erupted in the spring of 1983 with the simultaneous occurrence of two major strikes, which were impressive because of their long duration and acceptance by the public. A strike by medical students lasted 3 months and a strike by university hospital residents (interns) and assistant professors (chefs de clinique) lasted 6 weeks. Thus, at one time, all medical students, house staff, and junior faculty in all university hospitals throughout the country were on strike.Why did these strikes occur and what has been their impact on the French system of medical education, training, and practice?...Reference1. LEIGHTON R, DROBINSKI G, and GROSGOGEAT Y. La vie médicale en France: 1983. Ann Intern Med. 1983:99:122-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GÉRARD DROBINSKI, M.D.; DANIEL THOMAS, M.D.; YVES GROSGOGEAT, M.D.; RICHARD F. LEIGHTON, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAttitudes of Psychiatry Residents Toward a Strike by Nursing Staff 1 December 1983Volume 99, Issue 6Page: 862-863KeywordsMedical educationResidency ePublished: 1 December 2008 Issue Published: 1 December 1983 PDF downloadLoading ...