tbuckley/cabot-search huggingface dataset:
Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.
Authors: S Sankar, N Mahooti-Brooks, L Bensen, T L McCarthy, M Centrella, J A Madri
Journal: Journal of Clinical Investigation (1996)

Microvascular endothelial cells (RFCs) cultured in two-dimensional (2D) cultures proliferate rapidly and exhibit an undifferentiated phenotype. Addition of transforming growth factor beta1 (TGFbeta1) increases fibronectin expression and inhibits proliferation. RFCs cultured in three-dimensional (3D) type I collagen gels proliferate slowly and are refractory to the anti-proliferative effects of TGF beta1. TGF beta1 promotes tube formation in 3D cultures. TGF beta1 increases fibronectin expression and urokinase plasminogen activator (uPA) activity and plasminogen activator inhibitor-1 (PAI-1) levels in 3D cultures. Since the TGF beta type I and II receptors have been reported to regulate different activities induced by TGF beta1, we compared the TGF beta receptor profiles on cells in 2D and 3D cultures. RFCs in 3D cultures exhibited a significant loss of cell surface type II receptor compared with cells in 2D cultures. The inhibitory effect of TGF beta1 on proliferation is suppressed in transfected 2D cultures expressing a truncated form of the type II receptor, while its stimulatory effect on fibronectin production is reduced in both 2D and 3D transfected cultures expressing a truncated form of the type I receptor. These data suggest that the type II receptor mediates the antiproliferative effect of TGF beta1 while the type I receptor mediates the matrix response of RFCs to TGF beta1 and demonstrate that changes in the matrix environment can modulate the surface expression of TGF beta receptors, altering the responsiveness of RFCs to TGF beta1.
Natural killer cells in lymphomatoid granulomatosis
Authors: N. Rooney, D. Slater, A. Clark, Margaret Wood, Christine Harrington
Journal: British Journal of Dermatology (1984)

Journal Article Natural killer cells in lymphomatoid granulomatosis Get access N. Rooney, N. Rooney Department of HIstopathology and Dermatology Royal Halamshire Hospital, Sheffield SIO 2JF Search for other works by this author on: Oxford Academic Google Scholar D. Slater, D. Slater Department of HIstopathology and Dermatology Royal Halamshire Hospital, Sheffield SIO 2JF Search for other works by this author on: Oxford Academic Google Scholar A. Clark, A. Clark Department of HIstopathology and Dermatology Royal Halamshire Hospital, Sheffield SIO 2JF Search for other works by this author on: Oxford Academic Google Scholar Margaret Wood, Margaret Wood Department of HIstopathology and Dermatology Royal Halamshire Hospital, Sheffield SIO 2JF Search for other works by this author on: Oxford Academic Google Scholar Christine Harrington Christine Harrington Department of HIstopathology and Dermatology Royal Halamshire Hospital, Sheffield SIO 2JF Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 110, Issue 2, 1 February 1984, Pages 248–249, https://doi.org/10.1111/j.1365-2133.1984.tb07480.x Published: 01 February 1984
Progression of a Pedunculated Polyp
Authors: Kuangi Fu, Yasushi Sano
Journal: New England Journal of Medicine (2006)

A 56-year-old man underwent a colonoscopy after a positive fecal occult-blood test. Colonoscopy revealed two pedunculated polyps, one in the ascending colon and one in the transverse colon. One polyp was removed with a polypectomy snare (Panel A), but removal of the other was deferred owing to procedural difficulties. Unfortunately, the patient did not return for follow-up, for personal reasons. Five years later, he returned to our hospital after another positive fecal occult-blood test. Colonoscopy revealed a lesion, 15 mm in diameter, at the site of the previously detected pedunculated polyp (Panel B); no additional polyps were found. Complete surgical . . .
Relationship of the effects of interferon on chronic hepatitis B and the induction of 2′, 5′- oligoadenylate synthetase
Authors: Shuhei Nishiguchi, Tetsuo Kuroki, Shuzo Otani, Tadashi Takeda, Satoshi Hirota, Yutaka Shimizu, Shinya Nakajima, Shinobu Saito, Susumu Shiomi, Kenzo Kobayashi
Journal: Hepatology (1989)

Two years or more after 35 patients (29 men and six women) with chronic hepatitis B were treated by interferon, we studied relationships of age, ALT activity, activity of serum DNA polymerase associated with the hepatitis B virus, serum levels of hepatitis B e antigen and activity of 2',5'-oligoadenylate synthetase in peripheral blood mononuclear cells when treatment started in comparison with treatment results. Seventeen patients were given human lymphoblastoid interferon-alpha; the other 18 patients were given interferon-beta. We measured the activity of 2',5'-oligoadenylate synthetase in these mononuclear cells and found the rate of increase in vivo and in vitro; the correlation between the two was r = 0.68. This enzyme activity in the patients who became negative for DNA polymerase after interferon treatment increased more both in vivo and in vitro than in patients who did not became negative. Also, both the in vivo and in vitro activity increased more in patients who became negative for the e antigen after interferon therapy than in those who remained positive. In the first group, interferon was considered to be effective; in the second, ineffective. Of the patients who became negative, some developed e antibodies and some did not; the increase in this enzyme activity in the two groups was not significantly different. The increase in the activity of 2',5'-oligoadenylate synthetase activity could be used to predict the results of interferon treatment and is an index that can be used before treatment to predict the response.
Children are being denied intensive care.
Authors: N R Bennett
Journal: BMJ (1993)

know which recessive genes they carry"?Current evidence from a general practice population of reproductive age shows that "there is not a great deal of demand or interest in cystic fibrosis carrier testing" and that "such testing is not really wanted."2An editorial on the same subject in the Lancet concluded that "we need to think very carefully about whether nationwide programmes are what we really want and what the aims and ethical base of such an approach may be."3Before further research is carried out a national commission with representative membership needs to consider all the implications of screening the general population for cystic fibrosis and whether the potential benefits to society truly outweigh all the costs.
Features and Outcomes of Patients Who Underwent Cardiac Device Deactivation
Authors: Lillian C. Buchhalter, Abigale L. Ottenberg, Tracy L. Webster, Keith M. Swetz, David L. Hayes, Paul S. Mueller
Journal: JAMA Internal Medicine (2013)

Little is known about patients who undergo cardiovascular implantable electronic device deactivation.To describe features and outcomes of patients who underwent cardiovascular implantable electronic device deactivation.Retrospective review of medical records of 150 patients at a tertiary academic medical center (Mayo Clinic, Rochester, Minnesota). EXPOSURE Cardiovascular implantable electronic device deactivation.Demographic and clinical data and information regarding advance directives, ethics consultations, palliative medicine consultations, and cardiovascular implantable electronic device deactivations.Of the 150 patients (median age, 79 years; 67% were male), 149 (99%) had poor or terminal prognoses. Overall, 118 patients (79%) underwent deactivation of tachycardia therapies only, and 32 (21%) underwent deactivation of bradycardia therapies with or without tachycardia therapies (6 patients [4%] were pacemaker-dependent). Half of the deactivation requests (51%) were made by surrogates. A majority of deactivations (55%) were carried out by nurses. Although 85 patients (57%) had advance directives, only 1 mentioned the device in the directive. Ethics consultations occurred in 3 patients (2%) and palliative medicine consultations in 64 (43%). The proportions of patients who died within 1 month of device deactivation were similar for those who underwent deactivation of tachycardia therapies only and those who underwent deactivation of bradycardia therapies with or without tachycardia therapies (85% vs 94%; P = .37).Most requests for cardiovascular implantable electronic device deactivation were for implantable cardioverter-defibrillator-delivered tachycardia therapies only. Many of these requests were made by surrogates. Advance directives executed by patients with these devices rarely addressed device management. Regardless of device therapy, most patients died shortly after device deactivation. Hence, a device deactivation decision may reflect the seriousness of a given patient's underlying illness. Patients with devices should engage in advance care planning to ensure that future care is consistent with their preferences.
Give us food sense, not nonsense
Authors: Catherine Collins
Journal: BMJ (2007)

We describe three patients with lesions in the CNS that produced dissociated weakness of trapezius (TM) and sternocleidomastoid muscles (SCM). One patient with a right cerebral hemisphere lesion had left TM weakness and right SCM weakness. A second, with a brainstem lesion, and a third, with a high cervical cord lesion, had TM weakness with preserved SCM strength. We discuss the findings according to the known neuroanatomy.
UK inquiry finds people with learning disability receive less effective treatment
Authors: R. Dobson, A. Gulland
Journal: BMJ (2008)

People with learning disabilities have more unmet need and receive less effective treatment from the NHS, an independent inquiry has found.

The inquiry found that the United Kingdom’s estimated 1.5 million people with learning disabilities can face unnecessary suffering, and sometimes death, because laws and guidance that are designed to give them full access to health care are not being followed. In its report, Healthcare for All , the Independent Inquiry into Access to Healthcare for People with Learning Disabilities found that health service staff, particularly those working in general health care, had limited knowledge about learning disability.

The inquiry called for better training for all staff, better monitoring, and tougher inspections after a report by the learning disability charity Mencap, Death by Indifference , which detailed the cases of six people with a learning disability who had died and whose …
Osteoid Osteoma Involving Body of Right Rib
Authors: P VELUVOLU, T WINKLER, S M SAJJAD, R A LEER, S M FONTANINI
Journal: Clinical Nuclear Medicine (1992)

A rare case of osteoid osteoma involving the body of the right 9th rib is presented. The lesion, which was not identified by conventional radiography and tomography, was seen in bone scan. After preoperative localization, the resected rib was imaged for confirmation of surgical removal.
Mother who helped her seriously ill daughter to die is cleared of murder
Authors: Z. Kmietowicz
Journal: BMJ (2010)

A mother who administered a cocktail of drugs to her daughter whose own attempt at suicide had failed was cleared of attempted murder on 28 January.

Mr Justice Bean, the judge in the trial, praised the common sense, decency, and humanity of the jury at Lewes crown court, who took two hours to find Kay Gilderdale not guilty of attempting to murder her 31 year old daughter Lynn.

Kay Gilderdale had looked after her daughter 24 hours a day after she became severely disabled with myalgic encephalomyelitis.

In the early hours of 3 December 2008 Lynn injected herself with an overdose of morphine, but when she realised this was not enough she asked her mother for help.

Gilderdale tried to persuade her daughter not to take her life, but Lynn told her mother she wanted …
Proliferative response to fluid injection in psoriatic and normal human epidermis
Authors: GARY L. GROVE
Journal: British Journal of Dermatology (1980)

Feulgen-DNA cytophotometry revealed that human epidermal cell proliferation is regulated at a pre-DNA synthetic phase and can be perturbed by mild trauma. Although uninvolved psoriatic skin appears clinically normal, its hypersensitivity indicates abnormal proliferative behaviour and may serve as a marker of latent disease.
Fertilisation authority raids controversial fertility clinics
Authors: Lynn Eaton
Journal: BMJ (2007)

Doctors from more than a third of accident and emergency departments in hospitals in England said they were not reaching the government's target of dealing with patients within four hours.The main reason for this finding, from a survey published this week, was a shortage of available hospital beds, making it difficult for patients to be admitted.Only 49% of the nearly 500 members of the British Association for Emergency Medicine-all consultants and middle grade doctors-responding to the survey reported that their departments met the emergency access target for 98% of all patients to be seen, treated, admitted, or discharged within four hours.Although only 49% considered that their department actually met the emergency access target, 67% said that the figures reported by their department indicated that the target had been met.Respondents' comments on what had happened in their departments included, "Middle managers revising figures before being submitted," "Minor injury unit figures used to help achieve department's 96.9% target," and "Patients often 'moved' on the computer tracking but still kept in department to meet targets."Forty one per cent said that their depart- Lack of beds leads to missed government targetsment did not reach this target."Not enough available in-patient beds" was the main reason given for departments not meeting the emergency access target, and 88% of respondents reported it as a major contributory factor.Don MacKechnie, chairman of the BMA's emergency subcommittee and a consultant in emergency medicine at Pennine Acute Hospitals NHS Trust, said that financial problems in the NHS had meant that the availability of hospital beds for patients needing admission from accident and emergency departments was an important problem.He said, "In certain trusts, financial recovery measures have included closing beds previously used as 'safety valves' before, such as beds in rehabilitation wards.This has a knock-on effect to A&E [accident and emergency departments], with recovering patients that might have previously been moved remaining in acute beds."Mr MacKechnie said it was important that emergency access targets were seen as having broader application than simply affecting accident and emergency departments."Sometimes, other specialties forget that this is not just an A&E target.It is an emergency access target, with a responsibility from all specialties in an acute trust to ensure that the four hour target can be met."He said this meant ensuring that sufficient beds were available to admit patients from emergency departments and ensuring that doctors on call in each specialty are free to see patients in accident and emergency departments within the target of one hour after being referred.
ABSORB: EVALUATION OF THE BIORESORBABLE EVEROLIMUS-ELUTING VASCULAR SCAFFOLD (BVS) IN THE TREATMENT OF PATIENTS WITH DE NOVO NATIVE CORONARY ARTERY LESIONS: 1 YEAR ANGIOGRAPHIC, IVUS, IVUS-VH AND OCT RESULTS OF COHORT B
Authors: Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2011)
Abstract 2471: Direct down-regulation of eEF1A2 by Tumor suppressor p16INK4a inhibits cancer cell growth
Authors: Mee-Hyun Lee, Bu Young Choi, Yong-Yeon Cho, Myoung O. Kim, Sung-Hyun Kim, Cheol-Jung Lee, Ji Hong Song, Ann M. Bode, Zigang Dong, Yong-Joon Surh
Journal: Cancer Research (2014)

Abstract The tumor suppressor protein p16INK4a is a member of the INK4 family of cyclin-dependent kinase (Cdk) inhibitors, which are involved in the regulation of the eukaryotic cell cycle. However, the mechanisms underlying the anti-proliferative effects of p16INK4a have not been fully elucidated. Using yeast two-hybrid screening, we identified the eukaryotic elongation factor (eEF)1A2 as a novel interacting partner of p16INK4a. eEF1A2 is thought to function as an oncogene in cancers. The p16INK4a protein interacted with all but the D2 (250-327 aa) domain of eEF1A2. Computational docking study predicted that D24/D131 residues of p16INK4a interacted with eEF1A2 and it was confirmed by pull-down assay with mutant p16INK4a (D24A/D131E). Ectopic expression of p16INK4a decreased the expression of eEF1A2 and inhibited cancer cell growth. Furthermore, suppression of protein synthesis by expression of p16INK4a ex vivo was verified by luciferase reporter activity. Microinjection of p16INK4a mRNA into the cytoplasm of Xenopus embryos suppressed the luciferase mRNA translation, whereas the combination of p16INK4a and morpholino-eEF1A2 resulted in a further reduction in translational activity. We conclude that the interaction of p16INK4a with eEF1A2, and subsequent downregulation of the expression and function of eEF1A2 is a novel mechanism explaining the anti-proliferative effects of p16INK4a. Citation Format: Mee-Hyun Lee, Bu Young Choi, Yong-Yeon Cho, Myoung Ok Kim, Sung-Hyun Kim, Cheol-Jung Lee, Ji Hong Song, Ann M. Bode, Zigang Dong, Yong-Joon Surh. Direct down-regulation of eEF1A2 by Tumor suppressor p16INK4a inhibits cancer cell growth. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2471. doi:10.1158/1538-7445.AM2014-2471
Surgical Anatomy of the Kidney
Authors: Anthony J. Thomas
Journal: JAMA (1984)

In this text, the authors have presented various dimensions of renal anatomy and diagnostic techniques that need to be understood in order to appropriately carry out renal surgery. This book is particulary pertinent in light of the onset of endourologic manipulation, demanding a comprehensive knowledge of calyceal and vascular anatomy, which often exceeds that necessary in open surgery. This book would have been an ideal medium in which to introduce percutaneous techniques as they directly apply to endourologic manipulation. Although these techniques are not directly stated, by studying the chapters on intrarenal anatomy and surgery, the reader should gain sufficient knowledge applicable to this new technique. The first chapter on gross anatomy is somewhat difficult to follow because the cross-sectional photographs and figures are at the end of the chapter. The reader must turn from text to picture in order to understand more thoroughly what is being said. This sometimes
<i>N</i>-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions
Authors: A L Hubbard, D J Harrison, C Moyes, A H Wyllie, C Cunningham, E Mannion, C A D Smith
Journal: Gut (1997)

Genetic polymorphisms in N-acetyltransferase (NAT2) can change the normally fast acetylation of substrates to slow acetylation, and have been associated with the development of some cancers. The NAT2 locus may also suffer dysregulation during cancer progression, as the gene resides on chromosome 8p22, a region which is frequently deleted in colorectal cancer.A polymerase chain reaction based method was used to determine NAT2 genotype in 275 patients with colon cancer and 343 normal control DNAs. Within the cancer group, 65 cases known to contain deletions in chromosome 8p were examined for loss of heterozygosity at the NAT2 locus.Overall, there was no statistical difference in frequency or distribution of NAT2 alleles and genotype between colon cancer and control groups. There was a significant association between the slow acetylation genotype and early age of onset. NAT2 genotype did not vary with other clinical features of colon cancer, which included Dukes's stage, site of tumour, and sex. Of 48 informative cases, only three (6%) showed loss of heterozygosity, indicating that the NAT2 locus is not commonly deleted in colorectal cancer. This suggests that NAT2 is retained during the process of allele loss possibly because of its proximity to a gene necessary for cell viability.NAT2 does not play a major role in colorectal cancer risk, but may influence risk in some age groups. The nature of the loss of heterozygosity at the chromosome 8p site is complex and is worthy of further study.
Bone Marrow Island vs Focal Infection An lndium-111 Leukocyte Imaging Dilemma
Authors: GARY F. GATES, DAVID L. NOALL
Journal: Clinical Nuclear Medicine (1986)

An island of bone marrow surrounded by the glue used in securing a hip prosthesis accumulated ln-111 leukocytes in a patient being imaged for hip pain. This was shown to be normal marrow uptake of labeled cells and not an abscess by performing bone marrow imaging. The appearance of the leukocyte and bone marrow scans of the area were identical.
Analysis of predicted coronary heart disease risk in England based on Framingham study risk appraisal models published in 1991 and 2000
Authors: K. Nanchahal
Journal: BMJ (2002)

In 2000 the UK government launched the national service framework for coronary heart disease, setting national standards for improving prevention, diagnosis, and treatment. In agreement with recent recommendations on preventing coronary heart disease1 and managing hypertension,2 this programme includes use of coronary risk appraisal models from the Framingham study published in 19913 to help identify patients eligible for drug treatment. These models were updated in 2000,4 incorporating further follow up and additional risk factors. We compare the predicted risks calculated using the two models and assess the implications for preventing heart disease.

View this table:

Number of participants and mean (SD) risk in four year predicted risk categories based on coronary heart disease risk appraisal models from the Framingham study published in 19913 and 20004



The health survey for England is an annual, nationwide, household based, cross sectional surveyof a …