Minor Hemoglobins, Diabetic "Control," and Diseases of Postsynthetic Protein Modification
Authors: CHARLES M. PETERSON
Journal: Annals of Internal Medicine (1977)

Editorials1 October 1977Minor Hemoglobins, Diabetic "Control," and Diseases of Postsynthetic Protein ModificationCHARLES M. PETERSON, M.D., F.A.C.P., ROBERT L. JONES, M.D.CHARLES M. PETERSON, M.D., F.A.C.P.Search for more papers by this author, ROBERT L. JONES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-4-489 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough diabetes mellitus has been recognized as a clinical syndrome since the Ebers Papyrus, and the ideal therapy has been available in the form of replacement of the missing hormone since the 1920s, the disease continues to challenge the clinician through its almost ubiquitous sequelae. Hyperglycemia and ketosis are generally accepted as being the direct result of insulin deficiency. The causes of other sequelae are not as clear; complications often arise during long periods of time and may be due to insulinopenia, hyperglycemia, or other factors acting alone or in concert.With the advent of radioimmunoassays, measurements of hormone reserve...References1. KOENIGCERAMI RA: Synthesis of hemoglobin Alc in normal and diabetic mice. Potential model of basement membrane thickening. Proc Nat Acad Sci USA 72:3687-3691, 1975 CrossrefMedlineGoogle Scholar2. KOENIGARAUJOCERAMI RDA: Increased hemoglobin Alc in diabetic mice. Diabetes 25:1-5, 1975 CrossrefGoogle Scholar3. BUNNHANEYGABBAYGALLOP HDKP: Further identification of the nature and linkage of the carbohydrate in hemoglobin Alc. Biochem Biophys Res Commun 67:103-109, 1975 CrossrefMedlineGoogle Scholar4. BUNNHANEYKAMINGABBAYGALLOP HDSKP: The biosynthesis of human hemoglobin Alc: slow glycosylation of hemoglobin in vivo. J Clin Invest 57:1652-1659, 1976 CrossrefMedlineGoogle Scholar5. 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BOOKCHINGALLOP RP: Structure of hemoglobin Alc: Nature of the N-terminal β-chain blocking group. Biochem Biophys Res Commun 32:86-93, 1968 CrossrefMedlineGoogle Scholar11. KOENIGBLOBSTEINCERAMI RSA: Structure of carbohydrate of hemoglobin Alc. J Biol Chem 252:2992-2997, 1977 CrossrefMedlineGoogle Scholar12. HODGE J: The Amadori rearrangement. Adv Carbohydr Chem 10:169-205, 1955 MedlineGoogle Scholar13. STEVENSVLASSARAABATICERAMI VHAA: Nonenzymatic glycosylation of hemoglobin. J Biol Chem 252:2998-3002, 1977 CrossrefMedlineGoogle Scholar14. RAHBARBLUMENFELDRANNEY SOH: Studies of an unusual hemoglobin in patients with diabetes mellitus. Biochem Biophys Res Commun 36:838-843, 1969 CrossrefMedlineGoogle Scholar15. ROTHSTANFORDMAJERUS GNP: Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci USA 72:3073-3076, 1975 CrossrefMedlineGoogle Scholar16. PETERSONTSAIRISOHNISHILUGRADYCERAMIDYCK CPAYRAP: Sodium cyanate-induced polyneuropathy in patients with sickle-cell disease. Ann Intern Med 81:152-158, 1974 LinkGoogle Scholar17. KERNBELLHORNPETERSON HRC: Sodium cyanate induced ocular lesions in the beagle. J Pharmacol Exp Ther 200:10-16, 1977 MedlineGoogle Scholar18. COLEBUNNSOELDNER RHJ: New rapid assay method for hemoglobin (Hb-Alc) and total fast Hb (abstract). Diabetes 26(suppl 1):392, 1977 Google Scholar19. FLUCKIGERWINTERHALTER RK: In-vitro synthesis of hemoglobin Alc. FEBS Lett 71:356-360, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Rockefeller University New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCORRELATION BETWEEN SERUM MAGNESIUM AND LIPID PROFILE IN DIABETIC PATIENTS AND ITS ASSOCIATION WITH COMPLICATIONS.Evaluation of Glycemic Control Indexes During Pregnancy: The Role of HbA1c, Glycated Albumin, and FructosamineStudy of magnesium, glycosylated hemoglobin and lipid profile in diabetic retinopathyScreening System for the Maillard Reaction Inhibitor from Natural Product Extracts.Validated Fluorimetric HPLC Analysis of Acetaldehyde in Hemoglobin Fractions Separated by Cation Exchange Chromatography: Three New Peaks Associated with AcetaldehydeReview: Development of a fluid phase measure of acetaldehyde for biological samplesNon-enzymatic glycation of histonesGrowth behavior of Chinese hamster ovary cells in a compact loop bioreactor. 2. 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Goals, Limitations, and Evaluation of TherapyGlycosylated Plasma Protein Measurement by a Semi-Automated MethodInsulin, Oral Agents, and Monitoring TechniquesRapid cation-exchange chromatography of hemoglobins and other proteinsRelation of hemoglobin A1 and blood glucose to cardiac function in diabetes mellitusScreening for carbohydrate intolerance in pregnancy: A comparison of two tests and reassessment of a common approachNon-enzymatic glycosylation of skin collagen in patients with Type 1 (insulin-dependent) diabetes mellitus and limited joint mobilityGlycosylated hemoglobin as a screening test for carbohydrate intolerance in pregnancyContinuous subcutaneous insulin infusion (CSII) in insulin-dependent diabetesAn update on electrophoretic and chromatographic methods in the diagnosis of hemoglobinopathiesGlycosylated hemoglobin in patients treated by chronic dialysisThe determination of glycosylated hemoglobins in rats using high pressure liquid chromatographyEin Routineverfahren zur chromatographischen HB AI-Bestimmung mittels Mikros�ulentechnikHematologic alterations in diabetes mellitusGlycosylated haemoglobins in advanced malignancyLiver disease in patients with diabetes mellitus.Rapid fluctuations in glycosylated haemoglobin concentration as related to acute changes in blood glucoseA theoretical model to predict the behavior of glycosylated hemoglobin levelsTemporal relationship of glycosylated haemoglobin concentrations to glucose control in diabeticsReproducibility of Hemoglobin AIc and Sensitivity to Various Degrees of Glucose IntoleranceP. J. DUNN, M.B., Ch.B., R. A. COLE, M.D., J. S. SOELDNER, M.D., R. E. GLEASON, Ph.D.Increased endoneurial fluid pressure in galactose neuropathyRole of nonenzymatic glycosylation in the development of the sequelae of diabetes mellitusA Simple Microchromatographic Column for Determination of Hemoglobins A 1a+b and A 1cHaemoglobin A1 and diabetes mellitus 1 October 1977Volume 87, Issue 4Page: 489-491KeywordsDiabetes mellitusHemoglobinHormone replacement therapyHormonesHyperglycemiaInsulinInsulin-like growth factorsProteinsRadioimmunoassays Issue Published: 1 October 1977 PDF DownloadLoading ...