tbuckley/cabot-search huggingface dataset:
Do ACE Inhibitors Affect Diabetic Morbidity and Mortality?
Authors: Gerard S. Brungardt
Journal: Annals of Internal Medicine (1993)

Letters15 October 1993Do ACE Inhibitors Affect Diabetic Morbidity and Mortality?Gerard S. Brungardt, MDGerard S. Brungardt, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-8-199310150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In his discussion of angiotensin-converting enzyme (ACE) inhibitors and diabetic nephropathy, Bakris [1] implies that ACE inhibitors ultimately reduce the need for dialysis. Although ACE inhibitors have been shown to alter the rate of progression of proteinuria and preserve renal function, as stated by Bakris, I am unaware of data showing any change in morbidity or mortality rates. The assumption that morbidity and mortality rates will be affected is certainly logical, but we have been burned many times by similar past assumptions.REFERENCE1. Bakris GL. Angiotensin-converting enzyme inhibitors and progression of diabetic nephropathy. Ann Intern Med. 1993; 118:643-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1993Volume 119, Issue 8Page: 860-861KeywordsACE inhibitorsAngiotensin converting enzymeDeath ratesMedical dialysisMorbidityMortalityProteinuria ePublished: 15 August 2000 Issue Published: 15 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4
Authors: Madhukumar Venkatesh, Subhajit Mukherjee, Hongwei Wang, Hao Li, Katherine Sun, Alexandre P. Benechet, Zhijuan Qiu, Leigh Maher, Matthew R. Redinbo, Robert S. Phillips, James C. Fleet, Sandhya Kortagere, Paromita Mukherjee, Alessio Fasano, Jessica Le Ven, Jeremy K. Nicholson, Marc E. Dumas, Kamal M. Khanna, Sridhar Mani
Journal: Immunity (2014)
Patterns of Coronary Compromise Resulting in Acute Right Ventricular Ischemic Dysfunction
Authors: Terry R. Bowers, William W. O’Neill, Mark Pica, James A. Goldstein
Journal: Circulation (2002)

Background— Although proximal right coronary artery (RCA) occlusion is the culprit commonly responsible for acute right ventricular (RV) infarction (RVI), the severity of RV dysfunction ranges broadly. This study was designed to delineate the patterns of coronary compromise that determine the magnitude of RV ischemic dysfunction. Methods and Results— In 125 patients with acute inferior myocardial infarction undergoing emergency angiography, the culprit infarct lesion was identified, RV branch flow assessed (TIMI flows and frame counts), and individual patient RV perfusion indices calculated by separately averaging the branch flows and frame counts, which were correlated with RV wall motion by ultrasound. RVI occurred in 53 (42%) patients, with the RCA as the culprit vessel and the lesion sufficiently proximal to compromise flow in at least one RV branch in all cases, thereby resulting in depressed RV perfusion (flow index, 0.7±0.2). In patients without RVI, the RCA was the culprit in 89%; the circumflex, in 11%. RCA culprits were proximal in 19% of such cases, with lack of RVI explained by preserved RV perfusion (flow index, 2.7±0.3; P =0.001) attributable to at least 1 patent RV branch, spontaneous reperfusion, or prominent collaterals. Overall, there was a strong correlation between RV perfusion and wall motion (Spearman correlation coefficient=0.79). Conclusions— Proximal RCA occlusion compromising RV branch perfusion commonly results in RV ischemic dysfunction. In some cases with proximal RCA culprits, collaterals or spontaneous reperfusion preserve RV performance.
The Medical Scene in Israel Today
Authors: Alton I. Sutnick, Micha Levy
Journal: Annals of Internal Medicine (1975)

Abroad1 November 1975The Medical Scene in Israel TodayALTON I. SUTNICK, M.D., F.A.C.P., MICHA LEVY, M.D.ALTON I. SUTNICK, M.D., F.A.C.P.Search for more papers by this author, MICHA LEVY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-732 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIsrael probably has the largest number of doctors per capita of any country in the world (1:336 in 1973; second is the USSR with 1:360 in 1972). Physicians are not in great demand there as in the United States, and all groups and specialties face many problems. But they have a commitment to Israel; it is their country. Many of those born and trained in Israel have been offered academic positions in the United States. A few have accepted, but most have declined. They prefer to remain with their countrymen in their land of birth or immigration, the country in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1975Volume 83, Issue 5Page: 732-732KeywordsBirth Issue Published: 1 November 1975 PDF DownloadLoading ...
Solitary Hyperfunctioning Thyroid Adenoma in a Child
Authors: Harris C. Taylor
Journal: JAMA (1975)

THYROTOXICOSIS in the prepubertal patient is almost invariably due to Graves disease. The recent report of Popma et al<sup>1</sup>underscores, however, the responsibility of the solitary hyperfunctioning nodule for clinically significant hyperthyroidism in the pediatric patient. To our knowledge, this communication presents the second chemically documented example of hyperthyroidism due to a benign solitary hyperfunctioning adenoma in a child, and the first to produce both excessive thyroxine (T<sub>4</sub>) and triiodothyronine (T<sub>3</sub>) levels in the face of a normal serum thyroid-stimulating hormone (TSH) level. <h3>Report of a Case</h3> An 11 1/2-year-old girl was first seen in referral during December 1972. A previous physical examination in April 1971 had been normal. In February 1972, her pediatrician noted a right thyroid nodule. History disclosed some increase in sweating and a tendency to use fewer blankets at night. Her mother observed an increased irritability and a preference for the family room
Response of Aspirin-Allergic Patients to Challenge by Some Analgesics in Common Use
Authors: A. P. Smith
Journal: BMJ (1971)

Challenge tests with some analgesics in common use were performed in five aspirin-sensitive asthmatics. Marked falls in FEV(1) were observed after ingestion of paracetamol, indomethacin, mefenamic acid, and dextropropoxyphene in some subjects. The mechanisms of analgesic-induced asthma are discussed: it is believed to be a non-immunological process of great practical importance when prescribing analgesics to asthmatics.
Continuity of hospital care: beyond the question of personal contact
Authors: U. Krogstad, D. Hofoss, P. Hjortdahl
Journal: BMJ (2002)

Patients' experiences have placed continuity of hospital care on the agenda in Norway1 as in other countries. 2 3 Although continuity of care has a long history in the literature of primary care,4–9 the concept is not often related to hospital care. Most of such publications deal with long term hospitalisation,10 psychiatry,11 and nursing12 and focus on personal continuity—where one clinician is responsible for each patient. The reality of acute treatment and care in the hospital environment is ignored, and there is confusion over the concept of continuity of hospital care. 13 14

### Box 1 : Personal continuity may cause system discontinuity18

“Every time I or another patient asked for help the answer was always the same, ‘somebody else is responsible for you.’ I'm sure that if staff had given the service asked for instead of looking for the ‘right person,’ both the patients and the hospital would have saved time and frustration.”

“I'm satisfied with doctors and nurses, but you have to be really alert to make sure the information you give is passed through to the responsible persons. You never know if you are talking to the person in charge of you or just another messenger.” RETURN TO TEXT

Continuity of care is important for patients' satisfaction in primary and hospital care. 1 15 To compensate for the fragmented nature of specialised hospital care, many hospitals try to imitate primary care by designating one carer to a particular patient. This kind of personal continuity is important, but it does not ensure that patients receive the best treatment during their hospital stay. It is important to recognise that continuity of care when the carer is an institution differs in important aspects from continuity when the carer is a person.

We discuss continuity in relation to the fact that hospital care is an organised, multidisciplinary, …
TCT-302 Novel Index of Myocardial Mass At Risk Calculated From Cardiac Computed Tomography Data Had Significant Correlation With Two Angiographic Scores In Patients With Left Coronary Artery Stenosis
Authors: Seiko Ide, Satoru Sumitsuji, Kensuke Yokoi, Masatoki Yoshida, Isamu Mizote, Masaki Awata, Keita Yamasaki, Koichi Tachibana, Shinsuke Nanto, Yasushi Sakata
Journal: Journal of the American College of Cardiology (2014)
Postprandial duodenal function in man.
Authors: L J Miller, J R Malagelada, V L Go
Journal: Gut (1978)

Duodenal function was studied in 11 healthy volunteers after intragastric instillation of a mixed semi-elemental meal. The duodenum accepted chyme of varying pH, osmolality, and nutrient concentration; and, as a result of biliary, pancreatic, and enteric secretion as well as absorption, it delivered chyme with nearly constant pH, osmolality, and nutrient concentration to the jejunum. The flow rate and nutrient load of jejunal chyme varied. The duodenum absorbed more carbohydrate than lipid and less protein, taking up each nutrient at a constant rate during most of the postprandial period. The percentage of nutrient load absorbed was greatest in the late postprandial period, when flow rate, nutrient load, and concentrations were low.
THE INEFFECTIVENESS OF CALCIUM SALTS AND OF CITRIC ACID AS USED TO MODIFY THE COAGULATION TIME OF THE BLOOD FOR THERAPEUTIC PURPOSES: With a Description of a Modification of McGowan's Method of Estimating the Coagulation Time of the Blood
Authors: T. Addis
Journal: BMJ (1909)

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Swedish experience of two dose vaccination programme aiming at eliminating measles, mumps, and rubella.
Authors: M Bottiger, B Christenson, V Romanus, J Taranger, A Strandell
Journal: BMJ (1987)

In 1982 a two dose regimen was introduced in Sweden for the combined vaccination against measles, mumps, and rubella of children aged 18 months and 12 years. Since 1977 about half of the preschool children were vaccinated against measles annually, and since 1974 about 80% of 12 year old girls were vaccinated against rubella. During the period 1982 to 1985 90-93% of the eligible age cohorts of 18 month old children and 88-91% of the 12 year old children were immunised with the new combined vaccine. A study in 1982 of about 140 18 month old children who were nearly all seronegative before vaccination showed that 96%, 92%, and 99% seroconverted against measles, mumps, and rubella, respectively. A second study was carried out in 1983 of 247 12 year old children, of whom 11% lacked antibodies to measles, 27% to mumps, and 45% to rubella. This showed seroconversion in 82% and 80% against measles and mumps, respectively, and all children seroconverted against rubella. In the latest study in 1985 of 496 12 year olds 9% and 13% were seronegative against measles and mumps before vaccination, and 41% against rubella. Of these, 88% seroconverted to measles and 80% to mumps, and all converted to rubella when sera were tested by the haemolysis in gel method. After a neutralisation test against measles as well all children showed immunity to the disease. A low incidence of measles and declining figures for mumps and rubella were reported in 1984 to 1986. An outbreak of rubella during 1985 affected mainly boys in age cohorts in which only the girls had been vaccinated during the 1970s.
In vivo immune modulatory activity of hepatic stellate cells in mice
Authors: Cheng-Hsu Chen, Liang-Mou Kuo, Yigang Chang, Wenhan Wu, Christina Goldbach, Mark A. Ross, Donna B. Stolz, Liepin Chen, John J. Fung, Lin Lu, Shiguang Qian
Journal: Hepatology (2006)

Accumulating data suggest that hepatic tolerance, initially demonstrated by spontaneous acceptance of liver allografts in many species, results from an immune regulatory activity occurring in the liver. However, the responsible cellular and molecular components have not been completely understood. We have recently described profound T cell inhibitory activity of hepatic stellate cells (HSCs) in vitro . In this study, we demonstrate in vivo evidence of immune modulatory activity of HSCs in mice using an islet transplantation model. Co-transplanted HSCs effectively protected islet allografts from rejection, forming a multi-layered capsule, which reduced allograft immunocyte infiltrates by enhancement of apoptotic death. The immune modulation by HSCs appeared to be a local effect, and regulated by inducible expression of B7-H1, an inhibitory molecule of B7 family. This may reflect an intrinsic mechanism of immune inhibition mediated by liver-derived tissue cells. In conclusion , these results may lead to better understanding of liver immunobiology and development of new strategies for treatment of liver diseases.
Expression of secreted protein acidic and rich in cysteine (SPARC) in breast cancer and response to neoadjuvant chemotherapy
Authors: J.L. Lindner, S. Loibl, C. Denkert, B. Ataseven, P.A. Fasching, B.M. Pfitzner, B. Gerber, S. Gade, S. Darb-Esfahani, B.V. Sinn, J. Huober, K. Engels, H. Tesch, T. Karn, F. Pommerenke, C. Liedtke, M. Untch, V. Müller, B. Rack, C. Schem, G. von Minckwitz
Journal: Annals of Oncology (2014)
We need to move away from relying on drugs to prevent lifestyle induced chronic disease
Authors: E. Stamatakis, R. Weiler
Journal: BMJ (2012)

Spence’s article is based on the misleading claim that health promotion in England costs £3.7bn (€4.6bn; $6bn) a year.1 This figure is taken from table 3 of the 2009 NHS Public Health and Expenditure report and includes drugs (£1.4bn), dental check-ups (£1bn), the heavily drugs oriented Quality and Outcomes …
THE PERCEPTION OF LIGHT AND COLOUR
Authors: F. W. Edridge-Green
Journal: BMJ (1905)

TMEDILRTJUAL I77on the maximum points described by Dr. Henry Head.'The maximum points on which the incidences of this form of greyness are most common are the upoer mid-orbital and the occipital (Nos.I and 9 respectively in Fig. i; compare Fig. 2).
TCT-717 Coronary Microcirculation during Transfemoral Transcatheter Aortic Valve Implantation
Authors: Fadi Al-Rashid, Heike Hildebrandt, Theodor Baars, Karim El Chilali, Daniel Wendt, Matthias Thielmann, Heinz Jakob, Eva Kottenberg, Jürgen Peters, Raimund Erbel, Gerd Heusch, Philipp Kahlert
Journal: Journal of the American College of Cardiology (2014)
Practice Patterns and Perceptions of Thoracic Oncology Providers on Tobacco Use and Cessation in Cancer Patients
Authors: Graham W. Warren, James R. Marshall, K. Michael Cummings, Benjamin Toll, Ellen R. Gritz, Alan Hutson, Seyedeh Dibaj, Roy Herbst, Carolyn Dresler
Journal: Journal of Thoracic Oncology (2013)
1116-33 Renal transplant function as a risk factor for cardiovascular events and for all cause mortality in a renal transplant population: Experience from the ALERT trial
Authors: Bengt Fellström, H Holdaas, A Jardine, E Cole, G Nyberg, C Gronhagen-Riska, S Madsen, H Neumayer, B Maes, P Ambuhl, I Holme, P Faucald, T Pedersen
Journal: Journal of the American College of Cardiology (2004)
Malpractice Reform and Medical Injury
Authors: Stanley J. Zimmerman
Journal: Annals of Internal Medicine (2004)

Letters7 September 2004Malpractice Reform and Medical InjuryStanley J. Zimmerman, MDStanley J. Zimmerman, MDFrom Houston, TX 77054.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-5-200409070-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the article by Dr. Schoenbaum and Mr. Bovbjerg titled “Malpractice Reform Must Include Steps To Prevent Medical Injury” (1). Unfortunately, articles such as this (and many have appeared in different medical journals) all point to the physician. Having practiced and taught medicine for over 30 years, I believe that my colleagues do an excellent job caring for and treating their patients. Despite randomized, controlled studies, there is a great variation in the application of medical care. Medicine remains an art.Approximately 80% of all malpractice suits filed in the state of Texas are ...Reference1. Schoenbaum SC, Bovbjerg RR. Malpractice reform must include steps to prevent medical injury. Ann Intern Med. 2004;140:51-3. [PMID: 14706972] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Stanley J. Zimmerman, MDAffiliations: From Houston, TX 77054. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMalpractice Reform Must Include Steps To Prevent Medical Injury Stephen C. Schoenbaum and Randall R. Bovbjerg Metrics 7 September 2004Volume 141, Issue 5Page: 406KeywordsAdverse reactionsDrugsLipidsLiverStatins ePublished: 7 September 2004 Issue Published: 7 September 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Justification for screening for chronic beryllium disease: closer to reality
Authors: M. D. Rossman
Journal: European Respiratory Journal (2008)

Chronic beryllium disease (CBD) appeared to be waning 30 yrs ago 1. In 1980, less than one case per year was reported and the incidence rate per ton of beryllium produced had declined from between five and 10, to less than 0.001. CBD appeared to be heading toward the medical archives as a success story of environmental control in the absence of understanding of the pathogenesis of the disease. However, in 1982, an immunological test performed on lymphocytes recovered from the bronchoalveolar lavage fluid demonstrated a marked increased in the number of beryllium-sensitive cells in the lung compared to the blood, strongly suggesting that CBD was a hypersensitivity to beryllium 2. The findings of that initial study were confirmed in larger studies 3 and by different investigators 4, 5. Around 10 yrs later, an immunological test (the beryllium lymphocyte proliferation test (BeLPT)) was initially used in cross-sectional studies and later in the surveillance and screening of current and former beryllium workers 6–8. Those studies demonstrated that CBD was not heading for the medical archives, but that the disease was present in much greater numbers than previously reported due to misdiagnosis of overt cases and the detection of early and …
Antiemetic Efficacy and pharmacokientic Analysis of the Serotonin Antagonist Ondansetron (GR 38032F) During Multiple-Day Chemotherphy With Cisplatin Prior to Autologous Bone Marrow Transplantation
Authors: Hillard M. Lazarus, Judy C. Bryson, Eloise Lemon, J. Frederick Pritchard, Jeffrey Blumer
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Antiemetic Efficacy and pharmacokientic Analysis of the Serotonin Antagonist Ondansetron (GR 38032F) During Multiple-Day Chemotherphy With Cisplatin Prior to Autologous Bone Marrow Transplantation Get access Hillard M. Lazarus, Hillard M. Lazarus Search for other works by this author on: Oxford Academic PubMed Google Scholar Judy C. Bryson, Judy C. Bryson Search for other works by this author on: Oxford Academic PubMed Google Scholar Eloise Lemon, Eloise Lemon Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Frederick Pritchard, J. Frederick Pritchard Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeffrey Blumer Jeffrey Blumer Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 22, 21 November 1990, Pages 1776–1778, https://doi.org/10.1093/jnci/82.22.1776 Published: 21 November 1990 Article history Received: 09 July 1990 Revision received: 06 September 1990 Accepted: 07 September 1990 Published: 21 November 1990
Nervous Infections during Epidemic of Influenza B
Authors: A. D. Leigh
Journal: BMJ (1946)

TREATMENT OF H. INFLUENZAE MENINGITIS BRMTISCL be overcome by introduction of air and heparin into the cerebrospinal canal, and it may be worth while to try her methods in such desperate cases.It need not be feared that children thus saved might prove to be crippled in one way or another for the rest of their lives.Regarding such consequences Alexander (private communication) states:" The experience in this country when both sulphadiaziiie and type-specific rabbit antiserum are used in combination for the treat- ment of influenzal meningitis indicates that any residual damage to the brain is exceedingly rare following recovery.This appears to be true even in very chronic cases of the disease which recover over a long period of time.For example, I know, as a result of my own experience and by talking over the experiences of a number of others, of only one case in which residual damage to the brain followed a child's recovery."In all, 5 out of 20 cases were treated with sulphonamides alone.Only one of these five recovered.Fifteen cases had combined sulphonamide-penicillin treatment and eight of them recovered.The total number of cases is too small and the methods of treatment varied too much to allow of statistical assessment.The only conclusion to be drawn is that the encouraging recovery rate suggests pushing to the limit the combined sulphonamide-peaicillin treatment, perhaps supported by specific antiserum.The sporadic occurrence of H. influenzae meningitis in this country makes it very difficult for any investigator, singlehanded, to work out a satisfactory routine treatment.It seems reasonable to suggest that cases of H. influenzae meningitis of the non-fulminant type should be concentrated in a number of treatment centres.An adequate method of treatment, as in the case of subacute bacterial endocarditis, might be evolved for the majority of cases, and a substantial number of children's lives might thus be saved.Summary A survey of the various methods of treating H. inifluenzae meningitis is presented.Clinical data are given of 19 cases of H. influenzae type b meningitis and of 1 case due to H. influenzae of the respiratory group.Of 5 cases treated only with sulphonamides, one recovered.Fifteen cases had combined sulphonamide-penicillin. treatment.Eight of these recovered.It is suggested that the combined administration of these drugs should be used more energetically in H. influenzae meningitis.In view of the good therapeutic results reported from the U.S.A. specific H. inifiutenzae type b rabbit anti- serum, which is now available in this country, should also be given.The establishment of a number of treatment centres to evolve a standard routine method of treatment is advocated.