tbuckley/cabot-search huggingface dataset:
Impact of Disseminating Quality Improvement Programs for Depression in Managed Primary Care
Authors: Kenneth B. Wells, Cathy Sherbourne, Michael Schoenbaum, Naihua Duan, Lisa Meredith, Jürgen Unützer, Jeanne Miranda, Maureen F. Carney, Lisa V. Rubenstein
Journal: JAMA (2000)

ContextCare of patients with depression in managed primary care settings often fails to meet guideline standards, but the long-term impact of quality improvement (QI) programs for depression care in such settings is unknown.ObjectiveTo determine if QI programs in managed care practices for depressed primary care patients improve quality of care, health outcomes, and employment.DesignRandomized controlled trial initiated from June 1996 to March 1997.SettingForty-six primary care clinics in 6 US managed care organizations.ParticipantsOf 27,332 consecutively screened patients, 1356 with current depressive symptoms and either 12-month, lifetime, or no depressive disorder were enrolled.InterventionsMatched clinics were randomized to usual care (mailing of practice guidelines) or to 1 of 2 QI programs that involved institutional commitment to QI, training local experts and nurse specialists to provide clinician and patient education, identification of a pool of potentially depressed patients, and either nurses for medication follow-up or access to trained psychotherapists.Main Outcome MeasuresProcess of care (use of antidepressant medication, mental health specialty counseling visits, medical visits for mental health problems, any medical visits), health outcomes (probable depression and health-related quality of life [HRQOL]), and employment at baseline and at 6- and 12-month follow-up.ResultsPatients in QI (n = 913) and control (n = 443) clinics did not differ significantly at baseline in service use, HRQOL, or employment after nonresponse weighting. At 6 months, 50.9% of QI patients and 39.7% of controls had counseling or used antidepressant medication at an appropriate dosage (P&lt;.001), with a similar pattern at 12 months (59.2% vs 50.1%; P = .006). There were no differences in probability of having any medical visit at any point (each P≥.21). At 6 months, 47.5% of QI patients and 36.6% of controls had a medical visit for mental health problems (P = .001), and QI patients were more likely to see a mental health specialist at 6 months (39.8% vs 27.2%; P&lt;.001) and at 12 months (29.1% vs 22.7%; P = .03). At 6 months, 39.9% of QI patients and 49.9% of controls still met criteria for probable depressive disorder (P = .001), with a similar pattern at 12 months (41.6% vs 51.2%; P = .005). Initially employed QI patients were more likely to be working at 12 months relative to controls (P = .05).ConclusionsWhen these managed primary care practices implemented QI programs that improve opportunities for depression treatment without mandating it, quality of care, mental health outcomes, and retention of employment of depressed patients improved over a year, while medical visits did not increase overall.
Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis
Authors: Xiaobing Ye, Jianqiang Ding, Xiaozhou Zhou, Guoqian Chen, Shu Fang Liu
Journal: The Journal of Experimental Medicine (2008)

To define the roles of endothelial-intrinsic nuclear factor κB (NF-κB) activity in host defense and multiple organ injury in response to sepsis, we generated double transgenic (TG) mice (EC-rtTA/I-κBαmt) that conditionally overexpress a degradation-resistant form of the NF-κB inhibitor I-κBα (I-κBαmt) selectively on vascular endothelium. The EC-rtTA/I-κBαmt mice had no basal, but a relatively high level of doxycycline-inducible, I-κBαmt expression. I-κBαmt expression was detected in endothelial cells, but not in fibroblasts, macrophages, and whole blood cells, confirming that transgene expression was restricted to the endothelium. When subjected to endotoxemia, EC-rtTA/I-κBαmt mice showed endothelial-selective blockade of NF-κB activation, repressed expression of multiple endothelial adhesion molecules, reduced neutrophil infiltration into multiple organs, decreased endothelial permeability, ameliorated multiple organ injury, reduced systemic hypotension, and abrogated intravascular coagulation. When subjected to cecal ligation and puncture–induced sepsis, the TG mice had less severe multiple organ injury and improved survival compared with wild-type (WT) mice. WT and EC-rtTA/I-κBαmt mice had comparable capacity to clear three different pathogenic bacteria. Our data demonstrate that endothelial NF-κB activity is an essential mediator of septic multiple organ inflammation and injury but plays little role in the host defense response to eradicate invading pathogenic bacteria.
Intracoronary Autologous Cardiac Progenitor Cell Transfer in Patients With Hypoplastic Left Heart Syndrome
Authors: Shuta Ishigami, Shinichi Ohtsuki, Suguru Tarui, Daiki Ousaka, Takahiro Eitoku, Maiko Kondo, Michihiro Okuyama, Junko Kobayashi, Kenji Baba, Sadahiko Arai, Takuya Kawabata, Ko Yoshizumi, Atsushi Tateishi, Yosuke Kuroko, Tatsuo Iwasaki, Shuhei Sato, Shingo Kasahara, Shunji Sano, Hidemasa Oh
Journal: Circulation Research (2014)

Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac defect. Recent studies have suggested that intracoronary administration of autologous cardiosphere-derived cells (CDCs) may improve ventricular function.The aim of this study was to test whether intracoronary delivery of CDCs is feasible and safe in patients with hypoplastic left heart syndrome.Between January 5, 2011, and January 16, 2012, 14 patients (1.8±1.5 years) were prospectively assigned to receive intracoronary infusion of autologous CDCs 33.4±8.1 days after staged procedures (n=7), followed by 7 controls with standard palliation alone. The primary end point was to assess the safety, and the secondary end point included the preliminary efficacy to verify the right ventricular ejection fraction improvements between baseline and 3 months. Manufacturing and intracoronary delivery of CDCs were feasible, and no serious adverse events were reported within the 18-month follow-up. Patients treated with CDCs showed right ventricular ejection fraction improvement from baseline to 3-month follow-up (46.9%±4.6% to 52.1%±2.4%; P=0.008). Compared with controls at 18 months, cardiac MRI analysis of CDC-treated patients showed a higher right ventricular ejection fraction (31.5%±6.8% versus 40.4%±7.6%; P=0.049), improved somatic growth (P=0.0005), reduced heart failure status (P=0.003), and lower incidence of coil occlusion for collaterals (P=0.007).Intracoronary infusion of autologous CDCs seems to be feasible and safe in children with hypoplastic left heart syndrome after staged surgery. Large phase 2 trials are warranted to examine the potential effects of cardiac function improvements and the long-term benefits of clinical outcomes.http://www.clinicaltrials.gov. Unique identifier: NCT01273857.
A Technic for Taking Down the Potts' Anastomosis
Authors: HOWARD D. SIRAK, CLARENCE I. BRITT
Journal: Circulation (1962)

A technic is described for definitive repair of patients with tetralogy of Fallot whose previously constructed aorticopulmonary (Potts') anastomosis has remained functional. Hypothermia without interruption of the circulation has been used to protect the patient during the brief interval after the shunt is obliterated and until cardiopulmonary bypass is established for the definitive intracardiac repair. The results in three children, followed up to 2 years, are reported.
Who Is a Peer?
Authors: Alan L. Buchman
Journal: Annals of Internal Medicine (2001)

Letters20 February 2001Who Is a Peer?Alan L. Buchman, MD, MSPHAlan L. Buchman, MD, MSPHNorthwestern University Medical School; Chicago, IL 60611 (Buchman)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-4-200102200-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The purpose of peer review is to protect scientific integrity and maintain public trust. This system is charged with preventing dispersal of erroneous data and conclusions. Peer review was constructed as a “checks and balances” system, similar to that used in the U.S. government: Congress (author), the President (reviewer), and the Supreme Court (editor).What constitutes a peer? Is a peer an “expert” with a competing theory or competing grant? Is it a friend who will disregard missing but important data? Recently, several journals have confronted potential conflicts of interest. Discussion of this issue has focused on ... Author, Article, and Disclosure InformationAuthors: Alan L. Buchman, MD, MSPHAffiliations: Northwestern University Medical School; Chicago, IL 60611 (Buchman) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeer-review for the peer-review system 20 February 2001Volume 134, Issue 4Page: 346-347KeywordsConflicts of interestForecastingPeer reviewPrevention, policy, and public healthResearch fundingSafety studiesScientists ePublished: 20 February 2001 Issue Published: 20 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Risk of gynaecomastia associated with cimetidine, omeprazole, and other antiulcer drugs
Authors: L A G. Rodriguez, H Jick
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objective</b> : To study the risk of gynaecomastia associated with cimetidine, misoprostol, omeprazole and ranitidine. <b>Design</b> : Open cohort study with nested case-control analysis. <b>Setting</b> : General practices in United Kingdom that had computerised offices, 1989-92. <b>Subjects</b> : 81 535 men aged 25-84 years who received at least one prescription for cimetidine, misoprostol, omeprazole, or ranitidine during the study period. <b>Main outcome measures</b> : New occurrences of idiopathic gynaecomastia diagnosed by general practitioner. <b>Results</b> : The relative risk of gynaecomastia for current users of cimetidine compared with non-users was 7.2 (95% confidence interval 4.5 to 11.3). Relative risks for misoprostol, omeprazole, and ranitidine were 2.0 (0.1 to 10.7), 0.6 (0.1 to 3.3), and 1.5 (0.8 to 2.6), respectively. Current users of cimetidine on a daily dose greater than equal to 1000 mg had more than 40 times the risk of developing gynaecomastia than non -users. The period of highest risk was seven to 12 months after starting cimetidine treatment. Spirono-lactone (relative risk 9.3 (3.3 to 26.1) and verapamil (9.7 (2.6 to 36.0)) were associated with a relative risk of gynaecomastia comparable to one for cimetidine. <b>Conclusions</b> : Use of cimetidine, but not the three other antiulcer drugs, is associated with a substantially greater risk of gynaecomastia in men. A strong dose-response relation was present among cimetidine users.
Corticotropin-releasing hormone inhibition of gonadotropin secretion during the menstrual cycle
Authors: A. Barbarino, L. De Marinis, G. Folli, A. Tofani, S.Della Casa, C. D'Amico, A. Mancini, S.M. Corsello, P. Sambo, A. Barini
Journal: Metabolism (1989)
A Prospective Study of Risk Factors and Historical Trends in Metronidazole Failure for Clostridium difficile Infection
Authors: Mary Y. Hu, Seema Maroo, Lorraine Kyne, Jeffrey Cloud, Sanjeev Tummala, Kianoosh Katchar, Valley Dreisbach, Laura Noddin, Ciarán P. Kelly
Journal: Clinical Gastroenterology and Hepatology (2008)
Expression of human macrophage metalloelastase gene in hepatocellular carcinoma: Correlation with angiostatin generation and its clinical significance
Authors: Manuel J. Rivas, Shigeki Arii, Masaharu Furutani, Tomika Harada, Masaki Mizumoto, Hiroyuki Nishiyama, Jun Fujita, Masayuki Imamura
Journal: Hepatology (1998)

Macrophage metalloelastase, a member of the human matrix metalloproteinase family, is believed to play an important role in angiostatin generation, which, in experimental studies, has an antiangiogenic function and is a key molecule in tumor dormancy. However, no clinical studies have been reported regarding the correlation between human macrophage metalloelastase (HME) gene expression and angiostatin production. Therefore, the present study was designed to evaluate the HME messenger RNA (mRNA) expression and angiostatin generation in hepatocellular carcinoma (HCC). Tumorous and contiguous nontumorous tissues were obtained from 40 HCC patients who underwent curative partial hepatectomy. By using Northern blot hybridization, HME mRNA was detected in 25 of the 40 HCC samples and, in all of these cases, the expression in tumorous tissues was stronger than in the nontumorous tissues. In situ hybridization identified the HCC cells as mainly responsible for the signals shown in Northern blot. Angiostatin was detected by Western blot mainly in tumors and showed significant association with HME mRNA expression in tumorous tissues ( P = .0008). The patients whose tumors did not express HME mRNA and, thus, did not produce angiostatin, demonstrated poorer survival than those whose tumors showed high expression of HME mRNA and angiostatin generation ( P = .002). The univariate and multivariate analyses revealed that HME mRNA expression is a new and independent variable affecting overall survival ( P = .001 and P = .03, respectively). These findings show that the HME gene is expressed in HCC being significantly associated with angiostatin generation by such tumors and that HME mRNA expression may serve as a new molecular prognostic marker in HCC patients after partial hepatectomy.
Acute and Chronic Cholecystitis
Authors: Stephen W. Meagher, Alexander J. A. Campbell
Journal: New England Journal of Medicine (1955)

THREE hundred and forty-two patients with a preoperative diagnosis of cholecystitis were operated on at the Boston City Hospital from January 1, 1951, to January 1, 1953. The records of 13 cases were not available for study; therefore, 96.2 per cent of the records of the entire group have been reviewed. The series comprised 99 cases with a preoperative diagnosis of acute cholecystitis and 230 cases with a preoperative diagnosis of chronic cholecystitis.Sex PrevalenceAcute cholecystitis appeared one and a half times more frequently in females whereas chronic cholecystitis appeared five times more frequently in females. Although it was . . .
Publications for Internists: The American College of Physicians and the British Medical Association
Authors: Kathleen Case
Journal: Annals of Internal Medicine (1989)

Editorials15 April 1989Publications for Internists: The American College of Physicians and the British Medical AssociationKathleen Case, MS, Edward Huth, MDKathleen Case, MSSearch for more papers by this author, Edward Huth, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-8-586 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe American College of Physicians (ACP) is publishing four new publications of particular value to internists.The second edition of the College's Guide for Adult Immunization, also known as the "green book," will be available in June. It includes an expanded chapter on travel, new information on the immunocompromised patient, and the latest information on the efficacy of influenza and hepatitis B vaccines. The guide was developed by the College's Task Force on Adult Immunization, and its content has been approved by the Board of Regents.The chapters inProviding Quality Care: The Challenge to Clinicianswere written especially to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Kathleen Case, MS; Edward Huth, MDAffiliations: American College of Physicians Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1989Volume 110, Issue 8Page: 586-586KeywordsHealth care qualityHepatitis BVaccines ePublished: 1 December 2008 Issue Published: 15 April 1989 Copyright & Permissions©1989 American College of PhysiciansPDF downloadLoading ...
Soft-tissue chondroma as a cause of calcinosis in a patient with CRKST syndrome
Authors: B. Celasun, A. Y. Aksu, R. Mas, R. Finci
Journal: British Journal of Dermatology (1993)

Journal Article Soft‐tissue chondroma as a cause of calcinosis in a patient with CRKST syndrome Get access B. Celasun, B. Celasun Department of Pathology. Gülhane Military Medical Academy and School of Medicine. Etlik. 06018 Ankara. Turkey Search for other works by this author on: Oxford Academic Google Scholar A. Y. Aksu, A. Y. Aksu Department of Pathology. Gülhane Military Medical Academy and School of Medicine. Etlik. 06018 Ankara. Turkey Search for other works by this author on: Oxford Academic Google Scholar R. Mas, R. Mas Department of Internal Medicine. Gülhane Military Medical Academy and School of Medicine. Etlik. 06018 Ankara. Turkey Search for other works by this author on: Oxford Academic Google Scholar R. Finci R. Finci Department of Pathology. Gülhane Military Medical Academy and School of Medicine. Etlik. 06018 Ankara. Turkey Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 128, Issue 2, 1 February 1993, Pages 225–230, https://doi.org/10.1111/j.1365-2133.1993.tb15158.x Published: 01 February 1993
Characterization of chemoresistant hepatocellular carcinoma in transgenic mice model and cytotoxic activity of novel nanoparticules associated doxorubicin
Authors: L. Barraud, P. Merle, E. Soma, L. Lefrancois, S. Guerret, P. Couvreur, C. Trepo, L. Vitvitski
Journal: Journal of Hepatology (2001)
Mitral valve repair in rheumatic disease. The flexible solution.
Authors: J M Bernal, J M Rabasa, F G Vilchez, J C Cagigas, J M Revuelta
Journal: Circulation (1993)

Mitral valve repair in rheumatic disease is technically more difficult, and there is little information on the long-term stability of this technique.From January 1975 to December 1990, 327 patients underwent mitral valve repair with the Duran flexible ring annuloplasty for rheumatic valve disease. Mean age was 45.4 +/- 12.6 years (range, 23 to 73 years). The techniques used for valve repair include a Duran flexible ring annuloplasty in all cases, commissurotomy in 272 (83.2%), papillary muscle splitting in 171 (52.3%), and subvalvular apparatus repair in 59 patients (18.0%). One hundred one patients required associated tricuspid valve surgery (30.8%). Hospital mortality was 3.36%, being lower for patients with isolated mitral valve repair (2.7%) than those with mitrotricuspid surgery (4.9%). Mean follow-up was 8.6 years (range, 1 to 17 years) and was 96.5% completed. Thirty-four patients required reoperation for severe mitral insufficiency in 12, mitral restenosis in 18, and aortic valve disease in 4. The actuarial curve free from reoperation for mitral cause at 16 years is 89.9 +/- 3.2%. Late mortality occurred in 42 patients (13.2%). Actuarial survival curve at 16 years is 84.0 +/- 3.2% for isolated mitral valve repair and 64.6 +/- 6.7% for mitrotricuspid patients.Mitral valve reconstruction with Duran flexible ring annuloplasty in rheumatic valve disease entails a low hospital mortality with satisfactory long-term clinical results.
Comprehensive analysis of ‘knockouts’ in Mixed Martial Arts (MMA)
Authors: Michael Hutchison, Michael Cusimano, David Lawrence, Tanveer Singh
Journal: British Journal of Sports Medicine (2013)

Objective To quantify and identify potential risk factors for knockouts (KOs) and technical KOs (TKOs) in Mixed Martial Arts fighters. Setting Ultimate Fighting Championship (UFC). Design Retrospective. Fight card and fighter data was collected from all numbered UFC events over a 4-year period ending in 2009. Publicly available databases and digital video images were used to retrieve all pertinent information. Outcome Measures Event characteristics (eg, location, date, etc), fighter demographics (eg, age, nationality, time since last match), match characteristics (eg, match significance, rounds fought), and injury mechanism. Results A total of 503 matches were reviewed of which 36% ended in either KO (58; 12%; 57.7 per 1000 AE) or TKO (119; 24%; 118.4 per 1000 AE). The prevalence of KOs was highest in fighters between ages 36 and 40 (20.6%). The mechanism of contact resulting in a KO was predominately a direct blow to the head by a fist. 20% of all TKOs occurred in the heavyweight class. 33.9% of title matches result in TKOs and one in five of all KOs occurred during the first minute of a round. Conclusion Most often the mechanism of contact resulting in a KO was direct blow to the head. We have identified factors which were associated with a higher incidence of KO or TKO including age, weight, fight significance, time within the round, and time since last fight. Acknowledgements The Canadian Institutes of Health Research (CIHR) Strategic Team in Applied Injury Research funded this research. Competing interests None.
Symposium on Use of Indicator-Dilution Technics in the Study of the Circulation
Authors: Thomas E. Piemme
Journal: JAMA (1962)

These are the published proceedings of a symposium held on Jan. 3, 1961, in Salt Lake City, sponsored jointly by the Council on Circulation of the American Heart Association and the Latter-Day Saints Hospital at Salt Lake City. It was first published as Part 2 of the March, 1962, issue of<i>Circulation Research</i>. Collected within the pages of this valuable little book are the thoughts, experiences, and discoveries of several of the most eminent investigators who have used the Stewart-Hamilton dye dilution principle. The organization of the symposium is admirable. The first 2 articles are devoted to nomenclature, symbols commonly used in indicator-dilution work, and the history of development of the technique. Three articles follow, examining in depth the theory and mathematical basis for the measurement of flow and volume by this method. Four articles discuss various types of indicators, their applications, and limitations. Two articles then assess the use
Acid-Fast Smears and Tuberculosis
Authors: K. D. STOTTMEIER
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 September 1975Acid-Fast Smears and TuberculosisK. D. STOTTMEIER, M.D.K. D. STOTTMEIER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-3-429 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The staff of the Mycobacteria Reference Laboratory feels that the results published by Drs. Boyd and Marr (Ann Intern Med 82:489-492, 1975) cannot be generalized and should not instill the suspicion that all laboratories turn out false-positive (55%) and false-negative (78%) microscopy results at a rate described in their paper. Our laboratory uses essentially the same methods as they described but processes almost 30 000 clinical specimens a year.In order to do a valid comparison, we evaluated our results of 1 July through 31 December 1974 according to Boyd and Marr, and tabulated them exactly the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: K. D. STOTTMEIER, M.D.Affiliations: Mattapan Chronic Disease Hospital 249 River Street Boston, Massachusetts 02126 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTuberculosis in the 1980s 1 September 1975Volume 83, Issue 3Page: 429-430KeywordsMicroscopyMycobacteriaResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1975 PDF downloadLoading ...