Baseline Measurement of Bone Mass Predicts Fracture in White Women
Authors: Siu L. Hui
Journal: Annals of Internal Medicine (1989)

Articles1 September 1989Baseline Measurement of Bone Mass Predicts Fracture in White WomenSiu L. Hui, PhD, Charles W. Slemenda, DrPH, C. Conrad Johnston Jr., MDSiu L. Hui, PhDSearch for more papers by this author, Charles W. Slemenda, DrPHSearch for more papers by this author, C. Conrad Johnston Jr., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-5-355 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudy Objective: To determine if a single bone mass measurement of the radius is predictive of future fractures at any site.Design: Observational study of a cohort of free-living subjects and a cohort of retirement-home residents with an average follow-up of 6.7 years and 5.5 years, respectively (range, 1 to 15 years for both cohorts).Setting: General community and a retirement home.Subjects: Volunteer sample of white women (386 free-living and 135 living in a retirement home) who were free of disease and were not receiving medication known to affect bone metabolism. In terms of physical condition subjects ranged from the totally independent to the wheelchair-bound.Measurements and Main Results:A radial bone mass measurement was done at the initial visit. Subsequent nonspine fractures were reported by the subjects at follow-up visits, which were less than a year apart in most cases, and verified with medical records. Cox regression was used to model time to first fracture as a function of age and bone mass. These analyses showed that for every 0.1 g/cm decrement in bone mass, the relative risk of fracture was 2.2 (CI, 1.7 to 2.8) for the free-living and 1.5 (CI, 1.2 to 1.9) for the retirement-home...References1. CummingsBlack SD. Should perimenopausal women be screened for osteoporosis? Ann Intern Med. 1986;104:817-23. LinkGoogle Scholar2. Ott S. Should women get screening bone mass measurements? [Editorial]. Ann Intern Med. 1986;104:874-6. LinkGoogle Scholar3. HallDavisBaran FMD. Bone mineral screening for osteoporosis. 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N Engl J Med. 1989;320:904-10. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Siu L. Hui, PhD; Charles W. Slemenda, DrPH; C. Conrad JohnstonJr., MDAffiliations: From the Indiana University School of Medicine and the Regenstrief Institute for Health Care. For current author addresses, see end of text. 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