tbuckley/cabot-search huggingface dataset:
Prevention of Cervical Cancer in Low-Resource Settings
Authors: Imre Boncz
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public health concerns grow over foot and mouth outbreak
Authors: M. Hunter
Journal: BMJ (2001)

Public health concerns are growing across the United Kingdom over the disposal of animals culled in the foot and mouth outbreak. With smoke from nearby pyres drifting daily over many village communities, fears of an increase in respiratory illness have compounded existing anxieties about the risk of decaying carcasses contaminating drinking water supplies and the toxic effects of excessive exposure to disinfectant.

Several health alerts have been reported. In Dumfries and Galloway air quality tests were ordered after Annandale and Eskdale Council for Voluntary Service claimed that bitumen, red diesel, and coal were being used …
Dural venous sinus thrombosis in a patient with sickle cell disease: Case report and literature review1
Authors: S.O. Ciurea, K.R. Thulborn, M. Gowhari
Journal: American Journal of Hematology (2006)

Abstract We report a case of dural venous sinus thrombosis (DVST) in a patient who developed seizures following exchange transfusion for treatment of acute chest syndrome associated with sickle cell disease. Evaluation with magnetic resonance imaging and magnetic resonance venography of the brain indicated left sigmoid sinus thrombosis. The history and laboratory evaluation did not reveal any other inherited or acquired hypercoagulable states. This is the fourth case of dural venous sinus thrombosis associated with sickle cell disease reported in literature. The patient had a favorable outcome with early treatment of unfractionated heparin. Am. J. Hematol. 81:290–293, 2006. © 2006 Wiley‐Liss, Inc.
Quantification of minimal residual disease in children with oligoclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy
Authors: V de Haas, OJHM Verhagen, AEGKr von dem Borne, W Kroes, H van den Berg, CE van der Schoot
Journal: Leukemia (2001)
Anniversary Reactions and Due Date Responses Following Abortion
Authors: Kathleen Franco, Nancy Campbell, Marijo Tamburrino, Steve Jurs, Judith Pentz, Cynthia Evans
Journal: Psychotherapy and Psychosomatics (1989)

Of 83 women who responded to surveys exploring postabortion coping, 30 women reported anniversary reactions associated with the abortion or due date. Women in the anniversary reaction group more often reported ambivalence about the decision to abort (p less than 0.007). This group also acknowledged fewer suicidal thoughts and attempts, but expressed more concern about verbally abusing their children (p less than 0.04). Strong trends toward dependency and somatoform disorders were present among anniversary group members (p less than 0.06). The authors recommend that physicians be alert to the possibility of hidden anniversary reactions of both physical and emotional nature during patient evaluation.
The efficacy of combination therapy using transarterial infusion of epirubicin and cisplatin, systemic infusion of 5-fluorouracil, and additional percutaneous ethanol injection for advanced hepatocellular carcinoma
Authors: J.W. Jang, S.K. Yoon, S.H. Bae, J.Y. Choi, S.H. Choi, J.M. Yang, N.I. Han, K.W. Chung, H.S. Sun
Journal: Journal of Hepatology (2003)
Does adipocyte hypercellularity in obesity exist?
Authors: R T Jung, M I Gurr, M P Robinson, W P James
Journal: BMJ (1978)

Adipose tissue samples were biopsied from three subcutaneous sites in 80 obese and 27 non-obese patients. Additional samples were taken from intra-abdominal sites in 44 of the patients. There was a small increase in the calculated number of fat cells in the more obese patients, but there was no relation between fat-cell number and obesity of childhood onset. Omental fat cells were one-third the size of subcutaneous cells. Thus the calculated number of fat cells, usually based solely on subcutaneous samples, is an underestimate of the true number, and most obese patients can accommodate their fat without needing to recruit new cells. The diagnosis of "hyperplastic" obesity--that is, an excess number of fat cells--is unreliable and its relation to infantile obesity doubtful.
The Integrated Inpatient Management Model
Authors: Laurence F. McMahon
Journal: Annals of Internal Medicine (1989)

The delivery and financing of health care have undergone a metamorphosis over the past 10 years. These changes have been particularly dramatic for hospital care. The new health care environment, with more prospective-payment and managed-care systems and less fee-for-service payment for both physicians and hospitals, has made physicians and hospitals mutually dependent. A hospital's long-term financial viability is now dependent largely on the practice style of its physicians. The Department of Internal Medicine at The University of Michigan has developed a new clinical management system called the Integrated Inpatient Management Model (IIMM). This new system includes a major revision of the hospital organization structure, new administrative information systems, and new clinical information systems. Physicians in the Department of Internal Medicine have assumed for the first time formal organizational responsibility for many aspects of the operations of the inpatient medical service. The IIMM represents a prototype of a system that we believe offers considerable promise for involving physicians to a much greater extent in the management of the nation's hospitals. We hope that describing the system in detail will facilitate the development of other systems for the management of the inpatient practice of internal medicine.
Significance of tubuloreticular structures forming in Daudi cells cultured with sera from mothers bearing infants with neonatal lupus erythematosus
Authors: Y. NITTA, M. OHASHI, M. MORIKAWA, H. UEKI
Journal: British Journal of Dermatology (2006)

It is known that infants with neonatal lupus erythematosus (NLE) may be born to mothers whose sera are positive for the anti-Ro/SSA antibody. However, women who have this antibody do not always give birth to children with NLE. We have demonstrated tubuloreticular structures in vascular endothelial cells in the skin lesions of infants with NLE. Tubuloreticular structures could no longer be detected at the site of the lesions once the annular erythema had resolved, and the anti-Ro/SSA antibody test had become negative. The probability of a child being born with NLE was assessed by observing whether tubuloreticular structures were formed in Daudi cells cultured with sera from eight mothers who were anti-Ro/SSA antibody positive. Tubuloreticular structures formed in Daudi cells cultured with sera from four mothers who bore infants with NLE, but not in Daudi cells cultured with sera from four other mothers who bore normal infants. These results suggest that women who are positive for the anti-Ro/SSA antibody have a higher risk of bearing infants with NLE if tubuloreticular structures are formed in Daudi cells cultured with sera from these women, whereas this risk is lower if tubuloreticular structures do not develop in Daudi cells.
US children are not getting enough vitamin D, studies conclude
Authors: J. H. Tanne
Journal: BMJ (2009)

Children in the United States may be at risk of cardiovascular disease because they are not getting enough vitamin D, two studies have reported.

The studies, in the 3 August online edition of Pediatrics , both used data from the 2001-4 national health and nutrition examination survey. They were done because other studies indicated that US adults with low concentrations of vitamin D had a higher risk of cardiovascular disease, but little was known about low vitamin D concentrations in children and adolescents.

A study by Michal Melamed, an assistant professor of medicine and epidemiology at Albert Einstein …
ASSOCIATION OF STENT THROMBOSIS AND PATTERNS OF NON-ADHERENCE TO ANTI-PLATELET REGIMENS IN STENTED PATIENTS: SIX MONTH RESULTS OF THE PARIS REGISTRY
Authors: Usman Baber, Antonio Colombo, Giora Weisz, Alaide Chieffo, C. Michael Gibson, Maria Alu, Pushpam Barathi, Ziad Sergie, David Cohen, David Moliterno, Bernhard Witzenbichler, Mitchell Krucoff, Philippe Steg, Roxana Mehran
Journal: Journal of the American College of Cardiology (2012)
Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.
Authors: J N Wilcox, K M Smith, L T Williams, S M Schwartz, D Gordon
Journal: Journal of Clinical Investigation (1988)

Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, using in situ hybridization. The predominant cell types found to express PDGF A and B chain mRNA are mesenchymal-appearing intimal cells and endothelial cells, respectively, with little or no expression detected in macrophages. The distribution of PDGF receptor mRNA containing cells was also examined and found to be localized predominantly in the plaque intima.
Points from letters: The resignation issue
Authors: J B Berry
Journal: BMJ (1976)

part-time consultant" is, if successful, always available to his patients and colleagues because the tradition of mixed medical practice has always meant availability as required, a true "whole-time doctor."I realise that I am perhaps over-emphasising the difference, but my reason for this is honourable and refers to a previous letter from my colleagues and myself (8 February, 1975, p 336).There is a difference between a profession and a trade.
Problems with Drug-Eluting Coronary Stents — The FDA Perspective
Authors: Neal I. Muni, Thomas P. Gross
Journal: New England Journal of Medicine (2004)

The introduction of drug-eluting coronary stents in the United States has rapidly and profoundly affected the field of interventional cardiology. Met with widespread anticipation by the clinical community, drug-eluting stents are now used in a majority of intracoronary stenting procedures, justifying their characterization as a "transforming technology." However, both such stents that are currently approved by the Food and Drug Administration (FDA), the Cordis Cypher sirolimus-eluting stent and the Boston Scientific Taxus Express2 paclitaxel-eluting stent, have also been associated with highly publicized adverse events after they were approved for marketing, leading some to question their safety. As a by-product of . . .
856 WAIST CIRCUMFERENCE AND PERIHEPATIC ADIPOSE TISSUE AS PREDICTIVE NON-INVASIVE MARKERS IN NAFLD
Authors: P. Neagoe, G. Ianosi, A. Amzolini, M. Popescu, M. Dinca, M. Calbureanu, V. Comanescu, A. Turculeanu
Journal: Journal of Hepatology (2011)
Modulation of Ca <sup>2+</sup> Channels by Cyclic Nucleotide Cross Activation of Opposing Protein Kinases in Rabbit Portal Vein
Authors: Victor Ruiz-Velasco, Juming Zhong, Joseph R. Hume, Kathleen D. Keef
Journal: Circulation Research (1998)

Abstract —Cyclic nucleotides are known to modify voltage-gated (L-type) Ca 2+ channel activity in vascular smooth muscle cells, but the exact mechanism(s) underlying these effects is not well defined. The purpose of the present study was to investigate the modulatory role of the cAMP- and cGMP-dependent protein kinase (PKA and PKG, respectively) pathways in Ca 2+ channel function by using both conventional and perforated-patch–clamp techniques in rabbit portal vein myocytes. The membrane-permeable cAMP derivative, 8-bromo cAMP (0.1 to 10 μmol/L), significantly increased (14% to 16%) peak Ba 2+ currents, whereas higher concentrations (0.05 to 0.1 mmol/L) decreased Ba 2+ currents (23% to 31%). In contrast, 8-bromo cGMP inhibited Ba 2+ currents at all concentrations tested (0.01 to 1 mmol/L). Basal Ca 2+ channel currents were significantly inhibited by the PKA blocker 8-Bromo-2′-O-monobutyryladenosine-3′,5′-monophosphorothioate, Rp-isomer (Rp 8-Br-MP cAMPS, 30 μmol/L) and enhanced by the PKG inhibitor β-Phenyl-1,N 2 -etheno-8-bromoguanosine-3′,5′-monophosphorothioate, Rp-isomer (Rp-8-Br PET cGMPS, 10 nmol/L). In the presence of Rp 8-bromo PET cGMPS (10 to 100 nmol/L), both 8-bromo cAMP (0.1 mmol/L) and 8-bromo cGMP (0.1 mmol/L) enhanced Ba 2+ currents (13% to 39%). The excitatory effect of 8-bromo cGMP was blocked by Rp 8-bromo MB-cAMPS. Both 8-bromo cAMP (0.05 mmol/L) and forskolin (10 μmol/L) elicited time-dependent effects, including an initial enhancement followed by suppression of Ba 2+ currents. Ba 2+ currents were also enhanced when cells were dialyzed with the catalytic subunit of PKA. This effect was reversed by the PKA blocker KT 5720 (200 nmol/L). Our results suggest that cAMP/PKA stimulation enhances and cGMP/PKG stimulation inhibits L-type Ca 2+ channel activity in rabbit portal vein myocytes. Our results further suggest that both cAMP and cGMP have a primary action mediated by their own kinase as well as a secondary action mediated by the opposing kinase.
Beginning a consultant career
Authors: M. Jennings
Journal: BMJ (1996)

The initial few weeks were marked by a blend of thoughts, feelings, and emotions, some more striking than others. To my surprise there was no fear or apprehension, no awe or trepidation, and no insecurity—but excitement, confidence, achievement, and anticipation. The most notable experience was coming to the grave realisation of where the buck now rested. This was the prevailing thought when I came face to face with a patient in a bed, and …
Infections Due to Group B Beta-Hemolytic Streptococci
Authors: Mart Mannik, J. Richard Baringer, Joseph Stokes
Journal: New England Journal of Medicine (1962)

STREPTOCOCCAL disease in man is most frequently the result of infection by organisms belonging to Lancefield's Group A. Group B streptococci are more commonly pathogenic for cattle and have only rarely been implicated in human infections. Since the advent of antibiotics, there have been even fewer reported cases of human disease resulting from Group B streptococci, and their clinical importance has not been emphasized. Three cases of severe infection due to this agent were observed at the Massachusetts General Hospital from January to May, 1961. The purpose of this report is to re-emphasize the fact that these organisms are occasionally . . .
Multifunctional polymersomes for cytosolic delivery of gemcitabine and doxorubicin to cancer cells
Authors: Rahul Nahire, Manas K. Haldar, Shirshendu Paul, Avinash H. Ambre, Varsha Meghnani, Buddhadev Layek, Kalpana S. Katti, Kara N. Gange, Jagdish Singh, Kausik Sarkar, Sanku Mallik
Journal: Biomaterials (2014)
Effect of nicotine on rectal mucus and mucosal eicosanoids.
Authors: F J Zijlstra, E D Srivastava, M Rhodes, A P van Dijk, F Fogg, H J Samson, M Copeman, M A Russell, C Feyerabend, G T Williams
Journal: Gut (1994)

Because ulcerative colitis is largely a disease of non-smokers and nicotine may have a beneficial effect on the disease, the effect of nicotine on rectal mucosa in rabbits was examined. Nicotine was given subcutaneously by an Alzet mini-pump in doses of 0.5, 1.25, and 2 mg/kg/day for 14 days to three groups of eight animals and compared with eight controls. Mean (SD) serum nicotine concentrations (ng/ml) were 3.5 (1.1), 8.8 (2.3), and 16.2 (5.2) respectively in the treated groups. The thickness of adherent mucus on rectal mucosa in controls (median 36 microns) was significantly reduced by low dose (22 microns, p = 0.0011), and increased by high dose nicotine (48 microns, p = 0.035). Incorporation of radioactive glucosamine into papain resistant glycoconjugates was unchanged, indicating that mucin synthesis was unaltered. Prostaglandins (PG) were reduced, in some cases significantly (6-keto PGF1 alpha, PGF2 alpha, and hydroxy-eicosatetraenoic acid), by nicotine, which showed an inverse dose dependence--with greatest inhibition in relation to the lowest dose. Nicotine, and possibly smoking, may affect colitis by an action on mucosal eicosanoids and on adherent surface mucus secretion in the rectum and large bowel.
The Toxic Village Print Shop
Authors: Thomas L. Kurt
Journal: JAMA (1990)

<h3>To the Editor.—</h3> With a mother who was an art teacher and a background as a medical toxicologist, I feel compelled to comment about the February 16, 1990,<i>JAMA</i>cover and Dr Southgate's<sup>1</sup>historical narrative. In this cover a boy is drinking from a cup while standing next to a table with food containers next to lead plates and lead type boxes. The federal lead standard enforced by the Occupational Safety and Health Administration, based on studies of the epidemiology of lead poisoning, does not allow the consumption of any food or drink in the workplace, because lead dust in the air can be transferred to food and food containers, as well as by unwashed hands of workers. In addition, children are more susceptible to the effects of lead, with neurobehavioral and IQ deficits shown in children at lower blood lead levels. While lead poisoning was common in
Screening for Gestational Diabetes-Reply
Authors: M. Scott Magee
Journal: JAMA (1993)

<h3>In Reply.</h3> —Dr Ring asks about perinatal morbidity in pregnancies with one rather than the usual two abnormal GTT values that are diagnostic for GDM. Previous studies show that a single GTT abnormality by NDDG criteria is associated with increased perinatal morbidity.<sup>1,2</sup>To investigate this question in our own data set, we first determined if individuals with one abnormal value by the NDDG criteria had increased perinatal morbidity. We previously found that 65 (3.2%) of the women screened had two elevated GTT values by NDDG criteria, the classical definition of GDM. An additional 60 women (3.0%) of those screened had one elevated GTT value by NDDG criteria. The macrosomia rate (birth weight, &gt;4000 g) was 29% in the GDM group and 25% in the group with one abnormal value, consistent with previous reports.<sup>1,2</sup>We then determined how many of the 60 individuals with one elevated NDDG value had
Rise of the Machines — Left Ventricular Assist Devices as Permanent Therapy for Advanced Heart Failure
Authors: James C. Fang
Journal: New England Journal of Medicine (2009)

Traditionally, the only definitive therapy for patients who have advanced, medically refractory heart failure was replacement of the heart with another human heart. However, transplantation is an inadequate option in light of the large number of potential candidates, the lack of donors, and the coexisting conditions that make most potential candidates ineligible for transplantation. In this context, ventricular assist devices, or heart pumps, become an attractive option for patients who have advanced heart failure.Rather than replacing the human heart completely, ventricular assist devices serve in a true “assistance” capacity by supplementing the cardiac output of the native but weakened . . .
P828 THE COMMON PNPLA3 VARIANT IS ASSOCIATED WITH HEPATIC STEATOSIS QUANTIFIED BY CONTROLLED ATTENUATION PARAMETER AND DETERMINES THE FATE OF PATIENTS WITH CHRONIC LIVER DISEASES
Authors: A. Arslanow, C.S. Stokes, S.N. Weber, F. Grünhage, F. Lammert, M. Krawczyk
Journal: Journal of Hepatology (2014)
Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death
Authors: Sandro Silva-Gomes, Ana G. Santos, Carolina Caldas, Cátia M. Silva, João V. Neves, Joanne Lopes, Fátima Carneiro, Pedro N. Rodrigues, Tiago L. Duarte
Journal: Journal of Hepatology (2013)
The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus
Authors: E. ABELL, D.G.C. PRESBURY, R. MARKS, D. RAMNARAIN
Journal: British Journal of Dermatology (1975)

Direct immunofluorescent (IF) staining was performed on biopsy specimens from fifty-three patients with active lichen planus. In fifteen of these cases uninvolved skin sites were also examined. Globular or cytoid body-like deposits of immunoglobulins, mainly IgM, were detected in forty-six of the active lesions, and in half the uninvolved skin biopsies. The deposition of fibrin in the papillary dermis and around follicular structures was seen only in the active lichen planus papules. The significance of these findings was assessed by comparison with the IF results obtained in 252 biopsies from various cutaneous disorders, stained by the same technique during the period of this study. Although the presence of immunoglobulin cytoid bodies and fibrin was found to be highly characteristic of lichen planus, these findings were not specifically diagnostic. Morphologically identical deposits were seen not infrequently in lupus erythematosus and in eczema. Active lesions of dermatitis herpetiformis, erythema multiforme and other rare dermatoses also showed these cytoid body-like immunoglobulin deposits.
Echocardiography in congenital and acquired absence of the pericardium. An echocardiographic mimic of right ventricular volume overload.
Authors: M N Payvandi, R E Kerber
Journal: Circulation (1976)

The purpose of this study was to investigate the echocardiographic effects of absence of the pericardium. Five patients with congenital complete absence of the left pericardium were studied. All had typical chest X-rays, four had cardiac catheterization which excluded any intracardiac shunts, and one had diagnostic pneumothorax. All five had an enlarged right ventricular dimension (RVD): 1.9 +/- 0.1 cm/m2 (normal: less than 1.3 cm/m2) and abnormal interventricular septal (IVS) motion (three Type A, two Type B). Sixteen additional patients were studied after pericardial stripping for a variety of conditions. In none was cardiopulmonary bypass used. Eight of these patients had preoperative echocardiograms; all showed normal IVS motion. After surgery RVD was large in all 16 patients, increasing from 1.0 +/- 0.2 cm/m2 preoperatively to 1.7 +/- 0.1 cm/m2 postoperatively, P less than 0.01. Fourteen of the 16 patients had abnormal IVS motion, nine Type A, and five Type B. We conclude that absence of the pericardium results in echocardiographic abnormalities which mimic those seen in right ventricular volume overload. This may be due to altered cardiac position and motion within the thorax resulting from loss of normal pericardial restraint.