tbuckley/cabot-search huggingface dataset:
My Right Knee
Authors: Benjamin L. Sapers
Journal: Annals of Internal Medicine (2005)

Letters2 August 2005My Right KneeBenjamin L. Sapers, MDBenjamin L. Sapers, MDFrom Rhode Island Hospital, Providence, RI 02903.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-3-200508020-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Berwick (1) writes with insight on some of the important inefficiencies and flaws in our system, but I fear his attitude speaks louder than his words. Gandhi appears several times in the article as if to provide an approving stamp of compassion, and Berwick calls for better care not only for his knee but for a “Thai with dengue or an African with AIDS.” But his is not a universal prescription for care; it is a prescription for grease to the squeaky wheel. He needs an appointment “any day [he] want[s] it” because he is “really ...Reference1. Berwick DM. My right knee. Ann Intern Med. 2005;142:121-5. [PMID: 15657160] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Benjamin L. Sapers, MDAffiliations: From Rhode Island Hospital, Providence, RI 02903.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMy Right Knee Donald M. Berwick My Right Knee Kevin C. Fleming My Right Knee Donald M. Berwick Metrics 2 August 2005Volume 143, Issue 3Page: 236-237KeywordsAIDSClimbingConflicts of interestDengue feverEmergency departmentFearHabitsHealth careKneesRunning ePublished: 2 August 2005 Issue Published: 2 August 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
IS MULTIVESSEL PRIMARY PCI ADVISABLE? DIFFERENCES IN CLINICAL OUTCOMES AMONG MEDICARE BENEFICIARIES WITHOUT CARDIOGENIC SHOCK UNDERGOING SINGLE VERSUS MULTI-VESSEL PCI DURING A PRIMARY ST-SEGMENT ELEVATED MYOCARDIAL INFARCTION HOSPITALIZATION IN FISCAL YEAR 2011
Authors: Aaron D. Kugelmass, Phillip P. Brown, David J. Cohen, Matthew R. Reynolds, Steven D. Culler, April W. Simon
Journal: Journal of the American College of Cardiology (2014)
Setting the Agenda for the Clinical Interview
Authors: Paul R. Minton
Journal: Annals of Internal Medicine (2006)

Letters21 February 2006Setting the Agenda for the Clinical InterviewPaul R. Minton, MDPaul R. Minton, MDFrom Senior Friendship Centers, Sarasota, FL 34235.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-4-200602210-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Drs. Baker, O'Connell, and Platt (1) presented an articulate, valuable, and enjoyable analysis of a major problem we physicians face in meeting the needs of our patients. Early in my 40 years of cardiology and internal medicine practice, I learned how to avoid another “doorknob” question that would add significant time to the visit. Before I start any important discussion with patients about their diagnoses and their testing and treatment recommendations, I ask: “Is there anyone with you today who you want to hear our discussion?”This question evolved after many instances of having to repeat my ...Reference1. Baker LH, O'Connell D, Platt FW. “What else?” Setting the agenda for the clinical interview. Ann Intern Med. 2005;143:766-70. [PMID: 16287811] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Senior Friendship Centers, Sarasota, FL 34235.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee Also“What Else?” Setting the Agenda for the Clinical Interview Laurence H. Baker , Daniel O'Connell , and Frederic W. Platt Metrics 21 February 2006Volume 144, Issue 4Page: 306KeywordsConflicts of interestGraduate medical education ePublished: 21 February 2006 Issue Published: 21 February 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 555: A role for XMRV in prostate tumor promotion <i>in vivo</i>
Authors: Brennen P. Comeaux, Olga Zolochevska, Marxa Figueiredo
Journal: Cancer Research (2012)

Abstract Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirusclosely related to murine leukemia viruses, which cause a variety of cancersand immunological and neurological diseases in mice. Whether XMRV plays a rolein cancer and other diseases remains controversial; some studies show apossible association, but there is currently no evidence that the virus is acausal agent for disease. Our hypothesis was that the 3′ long terminal repeat(LTR) from the XMRV genome is responsible for its oncogenic activity inprostate cells. We chose three regions from the XMRV 3′ LTR and tested thepotential of these regions in transactivating a cellular gene promoter whosehomolog is transactivated by MMLV in mouse cells. We examined thetransactivation potential in pre-cancerous and a panel of cancerous prostateepithelial cells. Our results showed that for certain 3′LTR regions inducenearly full transactivating activity, while others might comprise inhibitoryregions. Therefore, to better understand the mechanism by which the XMRV 3′ LTRregions might be inducing or inhibiting transactivation, we tested theirability to transactivate cellular genes related to transformation. We used asreporters plasmids containing binding sites for cellular transcription factors.The results showed several similarities in transactivation, suggesting commonactivation pathways for 3′LTR transactivating activity. Finally, we tested ifXMRV infection could enhance oncogenicity potential of prostate precancerousand cancerous cell lines. We examined this in vitro by assessing the rate of colonyformation in soft agar, and in vivo, using xenograft assays. The resultssuggested that cell lines infected with XMRV had enhanced in vitro colonyformation, as well as enhanced in vivo growth, however, addition of anothertumorigenic genetic alteration was required in conjunction with XMRV-infectionto induce enhanced tumor growth. Our data suggests that the XMRV 3′LTR may havea transactivating activity on cellular genes, and that XMRV stimulatepromotion/progression and not ‘initiation’ of tumorigenesis. These results arenovel since they represent for the first examinations of the role of XMRV intumorigenesis of prostate epithelial cell lines in vitro and in vivo andexaminations of the 3′LTR context of the virus upon transactivation of cellulargenes as a potential mechanism of cellular transformation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 555. doi:1538-7445.AM2012-555
Detecting <i>Stenotrophomonas maltophilia</i> Does Not Reduce Survival of Patients with Cystic Fibrosis
Authors: Christopher H. Goss, Kelly Otto, Moira L. Aitken, Gordon D. Rubenfeld
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Stenotrophomonas maltophilia is a gram-negative bacterium that has been cultured with increasing prevalence from the sputum of patients with cystic fibrosis (CF). We conducted a cohort study, using the Cystic Fibrosis Foundation Registry, to assess the effect of S. maltophilia on survival. We studied all patients in this registry from 1991 to 1997 who were older than 6 years of age, were S. maltophilia negative in the first year of enrollment, and had their CF diagnosed before the age of 45 years (n = 19,255 in the study). We compared patients who acquired S. maltophilia with those who did not, using survival analysis. A total of 1,673 (8.7%) had at least one sputum sample positive for S. maltophilia. Compared with patients without S. maltophilia, those patients positive for S. maltophilia had the following baseline characteristics before detection: lower FEV1 % pred (p < 0.001); older (p = 0.001); more likely to be female (p = 0.003); and more pulmonary exacerbations (p < 0.001), outpatient visits (p < 0.002), and total hospitalizations (p < 0.001). After controlling for differences in severity of disease and coinfection with Pseudomonas aeruginosa, the hazard ratio associated with S. maltophilia detection was 0.89 (95% confidence interval, 0.75–1.05). Although patients with CF who acquire S. maltophilia have more advanced disease than those who do not acquire this organism, detection does not independently affect short-term survival (3 years).
Long-Term Survival After Acute Myocardial Infarction Is Lower in More Deprived Neighborhoods
Authors: Cathryn Tonne, Joel Schwartz, Murray Mittleman, Steve Melly, Helen Suh, Robert Goldberg
Journal: Circulation (2005)

As part of the Worcester Heart Attack Study, a community-wide study examining changes over time in the incidence and long-term case-fatality rates of greater Worcester, Mass, residents hospitalized with confirmed acute myocardial infarction (AMI), we investigated the hypothesis that census tract-level socioeconomic position is an important predictor of survival after hospital discharge for AMI, after adjusting for demographic and clinical characteristics.Data were available for 3423 confirmed cases of AMI among metropolitan Worcester residents during the 4 study years of 1995, 1997, 1999, and 2001 who were followed up through the end of 2002. The mean age among patients was 69 years, and 58% were men. Using a multilevel Cox proportional hazards regression model, we estimated a 30% higher death rate after AMI for patients living in census tracts with the most residents living below the poverty line compared with patients living in the wealthiest census tracts (relative risk=1.30; 95% CI, 1.08 to 1.56). Similarly, patients living in census tracts with the highest proportion of residents with less than a high school education experienced a 47% higher death rate than patients living in census tracts with the lowest proportion of residents with less than a high school education (relative risk=1.47; 95% CI, 1.15 to 1.88).Within a medium-sized urban area, there are important variations in survival after hospital discharge for AMI that are associated with socioeconomic position. These associations persist after adjustment for demographic and clinical characteristics. Reasons for these differences warrant further investigation.
P1088 VITAMIN E AS THERAPY FOR CHILDREN WITH E ANTIGEN POSITIVE CHRONIC HEPATITIS B: RESULTS OF A RANDOMIZED CONTROLLED TRIAL
Authors: S. Fiorino, G. Verucchi, D. Comparcola, M. Pavoni, E. Grandini, E. Loggi, S. Maselli, L. Bacchi-Reggiani, P. Viale, M. Bernardi, P. Andreone
Journal: Journal of Hepatology (2014)
Anti-tetanus immunisation in orienteers.
Authors: J C Folan
Journal: British Journal of Sports Medicine (1985)

The present state of anti-tetanus immunisation amongst orienteering runners from 20 countries was assessed by questioning the orienteers as to when they last received an anti-tetanus injection. The results demonstrate that approximately 55% were within five years of their last injection, 18% were within 5-10 years, 12% were greater than 10 years and a further 15% did not know when or had never had an anti-tetanus injection.
Value of Tru-cut lung biopsy in focal and diffuse lung disease.
Authors: S Balslov, J Vestbo, K A Viskum
Journal: Thorax (1988)

The results of 382 consecutive Tru-cut lung biopsies were reviewed to evaluate this investigation. The age of the patients ranged from 16 to 84 years (median 63 years); 284 patients suffered from focal and 98 from diffuse lung disease. Of the 206 patients with focal disease in whom the final diagnosis was a malignancy, 161 (78%) had a correct biopsy diagnosis. Of the 78 patients in whom the final diagnosis was non-malignant disease, 60 (77%) had a correct biopsy diagnosis. In diffuse pulmonary disease the histological diagnosis was correct in 75 of 98 patients (77%). In focal benign disease and in diffuse disease the reliability of the diagnosis increased with the specificity of the diagnosis. Where the biopsy diagnosis was not in accordance with the final diagnosis, histological examination usually showed normal lung tissue (with or without non-specific inflammation), necrotic tissue, or no tissue at all. Two patients died from the procedure. Minor complications occurred in 18%. It is concluded that the usefulness of Tru-cut biopsy is not confined to malignant focal disease; it is also reliable in benign focal disease and diffuse pulmonary disease when a specific diagnosis is obtained.
Kinetic behavior of urea is different from that of other water-soluble compounds: The case of the guanidino compounds
Authors: Sunny Eloot, A.N. Torremans, Rita De Smet, Bart Marescau, Dirk De Wachter, Peter Paul De Deyn, Norbert Lameire, Pascal Verdonck, Raymond Vanholder
Journal: Kidney International (2005)
A Piece of My Mind
Authors: Matko Marušić
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A REVIEW OF THE RESULTS OF THE PHARMACOLOGICAL SHOCK THERAPY AND THE METRAZOL CONVULSIVE THERAPY IN NEW YORK STATE
Authors: JOHN R. ROSS, BENJAMIN MALZBERG
Journal: American Journal of Psychiatry (1939)

1. One thousand seven hundred and fifty-seven patients suffering from dementia præcox have been treated thus far with insulin hypoglycemia in the New York State Department of Mental Hygiene, and 1140 patients have been treated with metrazol. 2. The recovery and improvement rate in the cases of insulin treated cases is significantly in excess of the rate in the control group. Metrazol, on the other hand, produced even fewer recovered cases than found in cases not treated by any shock therapy. 3. Recent reports indicate that metrazol, besides being not especially effective, also produces serious complications, notably fractured spines. While it is effective if used in selected cases in combination with insulin it is a dangerous drug and should not be used indiscriminately. 4. A follow-up study of cases approximately one year after completion of treatment indicates that a significant proportion of the patients tend to retain their improved state. 5. The prognosis in insulin treatment depends largely on: (a) Duration of the illness before treatment. (b) Type of dementia præcox. (c) Personality prior to the onset of the illness. 6. The adoption of the uniform application of treatment and a standardized method of recording will make possible more uniform success.
A Case of Osteo-Arthropathy in Phthisis
Authors: V. D. Harris
Journal: BMJ (1897)

OSTEO-ARTrIROPATHY IN PHTHISIS.F THz BaLRls7 daily twice syringed out (i in 2,000 perchloride,) and at each of these dressings some discharge was Rucked out from the drainage tube by a glass syringe, and a teaspoonful of i in x,ooo perchloride injected back to wash out the cavity, seven or eight spoonfuls being used at dressing, but each spoonful was allowed to return before injecting the next, so that there should be no fear of distending the sac and breaking the adhesions.At the end of a fortnight nothing was coming
Consultant contracts--region or district?
Authors: J. Brice, R M Buckle, J. Burn, M I D Cawley, I G Christie, R A Goodbody, J. Guthrie, I. Hyde, R D Hyde, L Langdon, R. Lea, I K R MacMillan, R A J Mayhew, J E Middleton, N. V Morgan, D J Pearce, G M Sterling, J H Winder, M B Yorston
Journal: BMJ (1982)
Intracranial Pressure in Reye Syndrome
Authors: Glenn W. Kindt
Journal: JAMA (1975)

Two patients who became comatose with Reye syndrome had continuous monitoring of intracranial pressure and blood pressure. Respirations were controlled, and mannitol and urea were administered to control elevated intracranial pressure. Continuous intracranial pressure monitoring proved to be a valuable adjunct to therapy for Reye syndrome. (<i>JAMA</i>231:822-825, 1975)
Tracking Progress in Patient Safety
Authors: Peter J. Pronovost, Marlene R. Miller, Robert M. Wachter
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychotropic Drugs In Addiction
Authors: Jeffrey Wiersum
Journal: JAMA (1974)

To the Editor.—  I feel moved to take exception to Dr. Blackwell's article, Psychotropic Drugs in Use Today, when he states the lack of abuse of diazepam (225:1637, 1973). Anyone like myself, who runs a drug treatment program, especially with methadone maintenance, knows of addictive abuse of these products. I would judge at least 30% of my patients have abused diazepam and a number of them had to be gradually withdrawn from dosage of 40 to 80 mg daily. They suffered severe withdrawal symptoms. Because of the central nervous system depressant action, diazepam also potentiates the depressant effect of methadone and makes for a very unmanageable patient.  I have seen this same depressant effect on patients other than addicts. We have all seen suicides in people robbed of their own defense mechanisms, after having their anxiety removed by diazepam. Consequently, unprotected against their depression, they succeed in their suicidal motives.
ADENOID VEGETATIONS IN THE NASOPHARYNX.
Authors: JOHN O. McREYNOLDS
Journal: JAMA (1899)

In this brief paper on adenoid vegetations in the nasopharynx I shall confine myself to a consideration of the measures which I have employed at different times, and especially those that I have found most satisfactory in the management of this condition. Its pathology and its importance are both so generally conceded that nothing appears to be required in order to establish these facts which are set forth in all works on laryngology. But as the method of dealing with this trouble has varied widely in the hands of different authorities, it might be well to briefly review these different procedures in the light of our individual experience. The treatment may be either medical or surgical, or the two may be very happily combined. In my judgment the surgical procedures are by far the most efficient, and they consist in the radical removal of the growths. The question of anesthesia
New Physician Education Initiatives Seek to Remove the Devil From the Detailing
Authors: Mike Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Levothyroxine Overdose Associated With Seizures in a Young Child
Authors: Kenneth Kulig
Journal: JAMA (1985)

IT IS estimated that approximately 18 million prescriptions for thyroid preparations are filled annually in the United States. Based on recent data from the American Association of Poison Control Centers, it has also been estimated that some 5,600 cases of thyroid overdose occur annually in this country.<sup>1</sup>Despite these figures, the reported cases of symptomatic patients after thyroid overdose have been few, presumably because of the generally benign nature of the subsequent clinical course. We recently were consulted on an unusual case of levothyroxine sodium poisoning in which clinical hyperthyroidism and convulsions occurred seven days after ingestion of the drug. <h3>Report of a Case</h3> A 30-month-old, previously healthy boy was thought to have ingested up to one hundred eighty 0.1-mg tablets of levothyroxine sodium (Synthroid) sometime between 9 and 11 AM, when his mother discovered that her pill bottle was open and that 180 tablets were missing. At 12:30