tbuckley/cabot-search huggingface dataset:
Babesiosis in Missouri
Authors: Barbara L. Herwaldt
Journal: Annals of Internal Medicine (1997)

Letters15 January 1997Babesiosis in MissouriBarbara L. Herwaldt, MD, MPH, Philip W. Taylor, MD, and Andre F. Gorenflot, PhDBarbara L. Herwaldt, MD, MPHCenters for Disease Control and Prevention, Atlanta, GA 30341Cape Girardeau Physician Associates, Cape Girardeau, MO 63703Universite Montpellier, 34060 Montpellier, FranceSearch for more papers by this author, Philip W. Taylor, MDCenters for Disease Control and Prevention, Atlanta, GA 30341Cape Girardeau Physician Associates, Cape Girardeau, MO 63703Universite Montpellier, 34060 Montpellier, FranceSearch for more papers by this author, and Andre F. Gorenflot, PhDCenters for Disease Control and Prevention, Atlanta, GA 30341Cape Girardeau Physician Associates, Cape Girardeau, MO 63703Universite Montpellier, 34060 Montpellier, FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-2-199701150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Drs. Byrd and Roy's interest in our paper. Our patient's diffuse pulmonary infiltrates (these were predominantly interstitial, but later some had an alveolar component) may have been multifactorial, as they commonly are in critically ill patients. Swan-Ganz catheter measurements suggested that the patient had volume overload, which was addressed with periodic hemodialysis. In addition, the patient was treated for pneumonia; Enterobacter cloacae was cultured from bronchial brushings and washings (no transbronchial lung biopsy specimen was obtained, and blood cultures were negative). We cannot rule out the possibility that the patient also had increased capillary permeability in ... Author, Article, and Disclosure InformationAffiliations: Centers for Disease Control and Prevention, Atlanta, GA 30341Cape Girardeau Physician Associates, Cape Girardeau, MO 63703Universite Montpellier, 34060 Montpellier, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1997Volume 126, Issue 2Page: 172KeywordsBabesiosisCapillariesCathetersEdemaEnterobacterLungsParasitemiaPathogenesisPneumoniaUpper respiratory tract infections Issue Published: 15 January 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Dual sensitization to rat and mouse urinary allergens reflects cross‐reactive molecules rather than atopy
Authors: H. Jeal, J. Harris, A. Draper, A. Newman Taylor, P. Cullinan, M. Jones
Journal: Allergy (2008)

Sensitization to rats and mice can develop in laboratory animal workers exposed to only one species. Reasons for this dual sensitization are unclear but may reflect a genetic predisposition to developing allergy (atopy) or alternatively cross-reactivity between rat and mouse urinary allergens. We examined cross-reactivity between rat and mouse urine and the effect atopy has on dual sensitization in laboratory animal workers.In a cross-sectional study the frequency of sensitization to rat and/or mouse was analysed in 498 employees exposed to both rat and mouse at work and 220 to rat only. RAST inhibitions, western blots and blot inhibitions were carried out on a subset of five individuals to assess cross-reactivity.Fourteen per cent of workers were sensitized to rats and 9% to mouse. Over half (62%) of rat sensitized individuals were also mouse sensitized and the majority (91%) of mouse sensitized individuals were also rat sensitized. IgE cross-reactivity was demonstrated between rat and mouse urine using RAST inhibitions. Rates of atopy did not differ between rat only sensitized individuals compared with those sensitized to both species. Sensitization to cats and rabbits was more common amongst those with dual sensitization.Dual sensitization to rat and mouse reflects IgE cross-reactivity rather than atopy. Individuals with dual sensitization are more likely to be sensitized to other animal allergens. These findings will have implications for individuals working with only one rodent species who develop sensitization and symptoms to be aware of the potential for allergy to other species.
Abstract P212: Elevated Uric Acid Levels and Risk of Ischemic Stroke among Women
Authors: Monik Jimenez, Hyon Choi, Gary Curhan, John Forman, Kathryn M Rexrode
Journal: Circulation (2013)

Introduction: Elevated uric acid has been inconsistently associated with a moderately increased risk of total stroke; however the data are sparse among women. Previous studies have failed to address variation by cardiovascular disease (CVD) risk factors and differentiate between stroke types. We aimed to examine the association between uric acid levels and ischemic stroke among women and evaluate effect modification by key CVD risk factors. Methods: The relationship between uric acid and ischemic stroke was examined using a nested case-control design among female participants of the Nurses’ Health Study who provided blood samples. Uric acid was measured on blood samples collected and stored between 1989-1990. The National Survey of Stroke criteria were utilized to confirm 460 incident cases of ischemic stroke by medical records from 1990-2006. Controls were matched to each case by age, menopausal status, hormone therapy use, ancestry, date of blood draw and smoking status. Multivariable conditional logist...
Carter's Science Budget
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1978)

In describing the research and development portion of the budget that President Carter sent to Congress last month, Frank Press, the White House science adviser, observed with satisfaction that it provides "a tilt toward basic research."Since scientists and others will be arguing over the adequacy of the "tilt" as the budget request proceeds through Congress, let's look at it in some detail, with particular emphasis on the segment for biomedical research. As is the case with all institutional budgets, policy is reflected in money, and the new budget — the first wholly prepared by the year-old Carter Administration — . . .
Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: A randomized, double-blind, placebo-controlled trial
Authors: Mani Kavuru, Julian Melamed, Gary Gross, Craig LaForce, Karen House, Barbara Prillaman, Leslie Baitinger, Anita Woodring, Tushar Shah
Journal: Journal of Allergy and Clinical Immunology (2000)
Cytomegalovirus infection in an HIV patient with duodenal papillitis
Authors: Y. Kim, Y. Cho, J. Lee, S. Jin, C. Shim
Journal: Endoscopy (2007)

A 52-year-old man had undergone appendectomy 2 months previously, at which time he was incidentally diagnosed with human immunodeficiency virus (HIV) infection. One month later, he revisited the hospital, complaining of vague abdominal pain with intermittent watery diarrhea. A colonoscopy was carried out, revealing multiple small ulcers in the ascending and transverse colon, biopsies from which revealed nonspecific inflammation. Two weeks later, he was hospitalized for persistent symptoms. Laboratory data demonstrated a white blood cell count of 1900/mm3 and a CD4+ lymphocyte count of 108/mm3. Chest radiography and abdominal computed tomography showed unremarkable findings. An upper endoscopy was performed. The esophagus and stomach showed unremarkable findings, but in the duodenum there was an edematous ampulla of Vater, with hyperemic mucosal changes in the second portion (Figure [1]). Histopathological examination revealed active papillitis with a few large cells infected with cytomegalovirus (CMV), confirmed by specific staining. Immunohistochemistry staining showed characteristic multiple viral inclusion bodies (Figure [2]).
Influence of propranolol isomers and atenolol on myocardial cyclic AMP, high energy phosphates and vulnerability to fibrillation after coronary artery ligation in the isolated rat heart
Authors: W. F LUBBE, C. A MULLER, M. WORTHINGTON, E L. McFADYEN, L. H OPIE
Journal: Cardiovascular Research (1981)

The isolated rat heart with ligation of the left coronary artery was used to assess the role of the beta 1- adrenergic receptor-cyclic AMP mechanism in the genesis of vulnerability to ventricular fibrillation in early myocardial ischaemia. Coronary artery ligation was followed after 3 min by a reduction in ventricular fibrillation threshold which reached a minimum at 15 min. This was accompanied by reduction of ATP and phosphocreatine while cyclic AMP was significantly increased in ischaemic myocardium. The dl-, l- and d-isomers of propranolol attenuated the decrease in ventricular fibrillation threshold and the increase in ischaemic myocardial cyclic AMP, without altering the tissue depletion of ATP. Specific beta 1-adrenergic receptor antagonism with atenolol did not prevent either the increase of tissue cyclic AMP or the reduction in ventricular fibrillation threshold and high energy phosphates. These findings suggest that the mechanism whereby vulnerability to fibrillation is increased in very early myocardial ischaemia is linked to changes in cyclic AMP content of ischaemic myocardium and appears independent of depletion of myocardial high energy phosphates.
Endothelial Microparticles in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study
Authors: Michael A. Thomashow, Daichi Shimbo, Megha A. Parikh, Eric A. Hoffman, Jens Vogel-Claussen, Katja Hueper, Jessie Fu, Chia-Ying Liu, David A. Bluemke, Corey E. Ventetuolo, Margaret F. Doyle, R. Graham Barr
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Basic research implicates alveolar endothelial cell apoptosis in the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. However, information on endothelial microparticles (EMPs) in mild COPD and emphysema is lacking. We hypothesized that levels of CD31(+) EMPs phenotypic for endothelial cell apoptosis would be elevated in COPD and associated with percent emphysema on computed tomography (CT). Associations with pulmonary microvascular blood flow (PMBF), diffusing capacity, and hyperinflation were also examined. The Multi-Ethnic Study of Atherosclerosis COPD Study recruited participants with COPD and control subjects age 50-79 years with greater than or equal to 10 pack-years without clinical cardiovascular disease. CD31(+) EMPs were measured using flow cytometry in 180 participants who also underwent CTs and spirometry. CD62E(+) EMPs phenotypic for endothelial cell activation were also measured. COPD was defined by standard criteria. Percent emphysema was defined as regions less than -950 Hounsfield units on full-lung scans. PMBF was assessed on gadolinium-enhanced magnetic resonance imaging. Hyperinflation was defined as residual volume/total lung capacity. Linear regression was used to adjust for potential confounding factors. CD31(+) EMPs were elevated in COPD compared with control subjects (P = 0.03) and were notably increased in mild COPD (P = 0.03). CD31(+) EMPs were positively related to percent emphysema (P = 0.045) and were inversely associated with PMBF (P = 0.047) and diffusing capacity (P = 0.01). In contrast, CD62E(+) EMPs were elevated in severe COPD (P = 0.003) and hyperinflation (P = 0.001). CD31(+) EMPs, suggestive of endothelial cell apoptosis, were elevated in mild COPD and emphysema. In contrast, CD62E(+) EMPs indicative of endothelial activation were elevated in severe COPD and hyperinflation.
AIDS Wrongly Diagnosed
Authors: Andrew Vernon
Journal: JAMA (1987)

To the Editor.—  The significance of a diagnosis of acquired immunodeficiency syndrome (AIDS) is widely appreciated and includes a grave prognosis as well as problems with medical expenses, employment, housing, and interpersonal relationships. Diagnosis of some AIDSdefining conditions requires considerable technical expertise. We report a case of misdiagnosis.  Report of a Case.—  A 58-year-old black man was admitted to a community hospital in July 1986 for dyspnea and mild nonproductive cough. He had used intravenous drugs (heroin and cocaine) for the prior 18 years. Physical examination revealed a large man in minimal distress; there were bibasilar rales, and multiple scars at sites of prior drug injection. His oral temperature was 37.6°C. The white blood cell count was 4.7×10 9 /L (4700/mm 3 ), with 0.30 (30%) lymphocytes; hemoglobin level was 119 g/L (11.9 g/dL). A chest roentgenogram demonstrated bilateral basal interstitial infiltrates; arterial oxygen partial pressure was 48 mm Hg. On
Animal Model That Mimics Atherosclerotic Plaque Rupture
Authors: Mark D. Rekhter, Gary W. Hicks, David W. Brammer, Carolyn W. Work, Jong-Seung Kim, David Gordon, Joan A. Keiser, Michael J. Ryan
Journal: Circulation Research (1998)

Abstract —Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We have developed a rabbit model in which an atherosclerotic plaque can be ruptured at will after an inflatable balloon becomes embedded into the plaque. Furthermore, the pressure needed to inflate the plaque-covered balloon may be an index of overall plaque mechanical strength. The thoracic aorta of hypercholesterolemic rabbits underwent mechanical removal of endothelial cells, and then a specially designed balloon catheter was introduced into the lumen of the thoracic aorta. As early as 1 month after catheter placement, atherosclerotic plaque formed around the indwelling balloon. The plaques were reminiscent of human atherosclerotic lesions, in terms of cellular composition, patterns of lipid accumulation, and growth characteristics. Intraplaque balloons were inflated both ex vivo and in vivo, leading to plaque fissuring. The ex vivo strategy is designed to measure the mechanical strength of the surrounding plaque, while the in vivo scenario permits an analysis of the plaque rupture consequences, eg, thrombosis. In addition, our model allows local delivery of various substances into the plaque. The model can be used to study the pathogenesis of plaque instability and to design plaque stabilization therapy.
774 POLARIZED NEUTROPHILS IN HEPATOCELLULAR CARCINOMA FOSTER IMMUNE PRIVILEGE AND DISEASE PROGRESSION VIA PD-L1
Authors: G.-X. He, H. Zhang, Y.-H. Chen, J.-X. Zhou, X.-W. Xie, R. Fei, H. Zeng, L. Wei, H.-S. Chen
Journal: Journal of Hepatology (2012)
Improving ethnic data within surveillance must be priority
Authors: A. Nicoll, M. Catchpole, J. M Watson
Journal: BMJ (1997)

<b>Background:</b> There is conflicting evidence from previous studies as to whether eosinophil counts predict the risk of future exacerbations in COPD. <b>Aims:</b> In this post hoc analysis, we investigated the link between baseline eosinophil count and moderate/severe exacerbation rates during the DYNAGITO trial. <b>Methods:</b> DYNAGITO was a 52-week, double-blind, randomised trial in patients with COPD with FEV<sub>1</sub> &lt;60% predicted, at least 1 moderate/severe exacerbation in the previous year and no diagnosis of asthma (NCT02296138). Exacerbation rates were analysed using a negative binomial model adjusting for prognostic factors such as region and exacerbation history. <b>Results:</b> At baseline, 81% of patients had an eosinophil count ≤300 cells/µL and 49% had an eosinophil count ≤150 cells/µL. 65–76% of patients were receiving ICS across eosinophil subgroups. Similar rates of moderate/severe exacerbations were observed across eosinophil subgroups (Figure). Rates were similar across eosinophil counts in patient subgroups with low or high exacerbation history. <b>Conclusions:</b> Relatively few patients had an eosinophil count &gt;300 cells/µL, and there was no increase in exacerbation rates with increasing baseline eosinophil count in the total population, or in patients with low or high exacerbation history. In this population, many of whom were receiving ICS, exacerbation history, but not blood eosinophil count, was an important determinant of exacerbation risk.
From the local medical committee conference Reaccreditation must take a lower priority Falling recruitment and morale must be addressed Conference censures GMSC over generic prescribing GPs doubt independence of review body Complaints procedure should be more flexible Home visits are anachronistic Registrars' continued unease with summative assessment GPs should not charge for travel vaccinations
Authors: L. Beecham
Journal: BMJ (1995)

# From the local medical committee conference {#article-title-2}

Representatives of Britain's general practitioners have called on their negotiators to see how their contract can be split between in hours and out of hours services. The decision, which was taken at last week's conference of representatives of local medical committees, came in the wake of the breakdown of talks with the minister for health over out of hours work (p 7). If an approach to the health secretary, Mrs Virginia Bottomley, is unsuccessful the General Medical Services Committee will make arrangements for a ballot on industrial action.

The conference was chaired by Dr George Rae (North Tyneside) with Dr Eric Rose (Bedfordshire) as his deputy. Both were re-elected unopposed.

Reports of some of the debates are published here.

# Reaccreditation must take a lower priority {#article-title-3}

Many general practitioners feel as strongly about reaccreditation as they do about out of hours work. This was obvious at the debate last week at the conference of representatives of local medical committees. The 1994 meeting had called for any system to be compulsory but the proposals from the General Medical Services Committee did not meet with universal approval. In its discussion document (25 February, p 536) the GMSC proposed that general practitioners would be reaccredited on a five year rolling cycle and that each doctor would be in contact at least once a year with a mentor who would exercise delegated authority on behalf of the regional adviser.

Although a motion rejecting the GMSC's discussion document was defeated, the conference resolved, by 143 votes to 88, that the subject should not be pursued until other matters, which had a higher priority, had been resolved. When the issue is negotiated the conference wants to be informed of the outcome before any scheme is implemented. The negotiators should insist on appropriate funding from new money and a significant reduction in workload to …
Diastolic Abnormalities as the First Feature of Hypertrophic Cardiomyopathy in Dutch Myosin-Binding Protein C Founder Mutations
Authors: Michelle Michels, Osama I.I. Soliman, Marcel J. Kofflard, Yvonne M. Hoedemaekers, Dennis Dooijes, Danielle Majoor-Krakauer, Folkert J. ten Cate
Journal: JACC. Cardiovascular imaging (2009)
ERYTHEMA MULTIFORME SIMULTANEOUSLY IN MOTHER AND CHILD: CASE-REPORT
Authors: ERIC GODWIN
Journal: British Journal of Dermatology (1938)

Journal Article ERYTHEMA MULTIFORME SIMULTANEOUSLY IN MOTHER AND CHILD: CASE‐REPORT Get access ERIC GODWIN, M.R.C.S., L.R.C.P. ERIC GODWIN, M.R.C.S., L.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 50, Issue 1, 1 January 1938, Pages 33–34, https://doi.org/10.1111/j.1365-2133.1938.tb10413.x Published: 01 January 1938
Diagnosing the tight building syndrome.
Authors: S A Rogers
Journal: Environmental Health Perspectives (1987)

Formaldehyde is but one of many chemicals capable of causing the tight building syndrome or environmentally induced illness (EI). The spectrum of symptoms it may induce includes attacks of headache, flushing, laryngitis, dizziness, nausea, extreme weakness, arthralgia, unwarranted depression, dysphonia, exhaustion, inability to think clearly, arrhythmia or muscle spasms. The nonspecificity of such symptoms can baffle physicians from many specialties. Presented herein is a simple office method for demonstrating that formaldehyde is among the etiologic agents triggering these symptoms. The very symptoms that patients complain of can be provoked within minutes, and subsequently abolished, with an intradermal injection of the appropriate strength of formaldehyde. This injection aids in convincing the patient of the cause of the symptoms so he can initiate measures to bring his disease under control.
Catabolism of human serum IgG in health, rheumatoid arthritis, and active tuberculous disease. Possible influence of IgG structure.
Authors: J Watkins, A J Swannell
Journal: Annals of the Rheumatic Diseases (1973)

Probably all macromolecules, whether naturally occurring or synthetic, are subject to ageing phenomena.The random movements of long flexible chains must inevitably end in rigid tangled con- figurations.Aged, denatured, or aggregated proteins in serum will no longer be able to carry out their predetermined functions and mechanisms must exist for their removal.The catabolic mechanism for serum proteins is probably initiated by recognition of the denatured molecule.A fault in this recognition might have serious pathological consequences for the individual con- cerned, especially when serum immunoglobulins are involved, since the participation of these proteins in the formation of immune complexes has given them a possible pathogenic role in diseases such as rheuma- toid arthritis (RA).Abnormal rates ofIgG elimination may be related to basic immunological mechanisms in rheumatoid arthritis and, ifthis is so, then catabolic studies may provide an additional means for the characterization of the disease.A study has been made of the catabolism of iodine-labelled serum IgG in health, rheumatoid arthritis, and active tuberculous disease to investigate this possibility. MethodsImmunologically pure IgG was isolated from the serum of five healthy individuals, six rheumatoid patients, and four patients with active tuberculous disease, by column chromatography on DEAE-cellulose (DE52, Whatman Limited, Maidstone, Kent) with 0 01M phosphate buffer, pH 6-2.Each immunoglobulin preparation was labelled (McFarlane, 1958) with iodine-125, and the autologous preparation (20 mg.IgG; 50,Ci) was injected intravenously into the individual concerned.Sodium iodide (40 mg) was administered daily to block thyroid uptake of radioactivity.Elimination of the labelled protein was followed by scintillation counting of serum samples at intervals of 2 to 3 days for a period of 32 days.
A computer graphic-based angiographic model for normal left ventricular contraction in man and its application to the detection of abnormalities in regional wall motion.
Authors: T H Shepertycki, B C Morton
Journal: Circulation (1983)

Analyzing the digitized left ventricular cineangiograms of 70 patients with no demonstrable heart disease (NDHD), we derived an angiographic model for normal contraction in the intact heart as viewed in the 30 degree right anterior oblique projection. This model was verified statistically by comparing the predicted regional stroke volumes with the measured volumes for the NDHD group. A wall motion system based on this model was compared with four other systems by examining the ventriculograms of 141 patients, all suffering from coronary artery disease but with normal volumes and ejection fractions (greater than 0.61). Of these, 60 had normally contracting ventricles and 81 exhibited mild regional abnormalities according to two experienced angiographers. Using Cochrane's Q test, we found significant differences among the five methods (Q = 29.5;p less than .001). The new approach showed significantly better agreement with the subjective assessment than the next best method (Q = 5.3;p less than .05). On a regional basis, overall sensitivity was 87.5% and specificity was 97.9%.