tbuckley/cabot-search huggingface dataset:
Tinea Faciei Simulating Other Dermatoses
Authors: Lewis Shapiro
Journal: JAMA (1971)

<i>In four cases of tinea faciei due to</i>Trichophyton mentagrophytes<i>each patient's dermatosis was clinically deceptive, and had masqueraded under diagnoses such as lupus erythematosus or contact dermatitis for periods of up to five months. A greater awareness of the possibility of unusual forms of facial ringworm should increase the number of cases in which it is correctly diagnosed</i>.
Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer
Authors: Tanya J. Shaw, Mary K. Senterman, Kerri Dawson, Colleen A. Crane, Barbara C. Vanderhyden
Journal: Molecular Therapy (2004)

Improvement of ovarian cancer patient outcome requires well-characterized animal models in which to evaluate novel therapeutics. Xenograft models are frequently used, but with little discussion of disease histology. The objectives of this study were to inject 11 ovarian cancer cell lines intraperitoneally (ip), and a subset intrabursally (ib; orthotopic), into nude mice and to analyze the resulting pathologies. Eight of 11 lines injected ip formed tumors within 3 months at variable rates with the following histological subtype distribution: one endometrioid, one serous, one clear cell, and five undifferentiated. Only mice injected with A2780-cp cells presented with ovarian-specific metastases (11 of 88), and the survival time of these animals was significantly shorter, which may be attributed to the higher proliferation rate as determined by Ki67 positivity. Additional analysis of the influence of the ovarian microenvironment on cell characteristics was conducted with ib injection of two cell lines (OVCA 429 and ES-2). The site of injection did not affect the tumor histology, the effect on proliferation was cell-type dependent, and the tumor take rate (cell survival) was negatively affected for OVCA 429 cells. The animal models described herein represent histologically distinct models of both early and late stage ovarian cancer useful for evaluation of therapeutics.
Common Behavioral Clusters and Subcortical Anatomy in Stroke
Authors: Maurizio Corbetta, Lenny Ramsey, Alicia Callejas, Antonello Baldassarre, Carl D. Hacker, Joshua S. Siegel, Serguei V. Astafiev, Jennifer Rengachary, Kristina Zinn, Catherine E. Lang, Lisa Tabor Connor, Robert Fucetola, Michael Strube, Alex R. Carter, Gordon L. Shulman
Journal: Neuron (2015)
P677Superresolution microscopy reveals proliferative T-Tubule remodeling as general disease mechanism in early stages of heart failure development
Authors: E Wagner, E Hebisch, JH Steinbrecher, V Westphal, G Hasenfuss, SW Hell, SE Lehnart
Journal: Cardiovascular Research (2014)

Purpose: Transverse tubules (T-Tubules, TTs) form a complex network of continuous membrane invaginations which are essential to ensure effective EC coupling in ventricular myocytes (VMs). Resolution limited microscopic studies suggested a loss of TTs as a leading mechanism in late stages of heart failure (HF). However, TTs have dimensions below the resolution limit of conventional light microscopy. Therefore, we employed superresolution microscopy and novel quantitative image analysis strategies to directly quantify TT remodeling in different stages during HF development.
Abstract A21: High-throughput small molecule screening of genetically diverse glioblastoma stem cells
Authors: Garth W. Strohbehn, Jiangbing Zhou, Michael Fu, Toral R. Patel, Joseph M. Piepmeier, W. Mark Saltzman
Journal: Cancer Research (2012)

Abstract Survival statistics for glioblastoma multiforme (GBM) have remained static despite years of research. Mounting evidence suggests that glioblastoma stem cells (GSCs) are a primary cause of GBM growth, spread, vascularity, and chemotherapeutic resistance. Increasing survival, therefore, demands a therapeutic strategy with efficacy against GSCs. To address this, we have conducted a high-throughput screen of over 3,000 small molecule compounds for activity against three independently derived GSC lines that vary in their expression of TCGA subtype-related genes. Our fluorescence-based assay is sensitive, reliable, and largely free of row- and column-based systematic errors. We identify novel compounds that impair the viability of all three of these genetically diverse GSC lines but have comparably limited toxicity against a normal human glial cell line. Many of these compounds are small and lipophilic, as well, making them ideal candidates for follow-up in vivo evaluation either through intravenous delivery or through encapsulation in polymeric nanoparticles. Citation Format: Garth W. Strohbehn, Jiangbing Zhou, Michael Fu, Toral R. Patel, Joseph M. Piepmeier, W. Mark Saltzman. High-throughput small molecule screening of genetically diverse glioblastoma stem cells [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr A21.
Cost effectiveness and equity are ignored
Authors: A. Maynard
Journal: BMJ (1996)

within the new journal can be divined.There is no reference to the second hand methodology, just the quoting of subjectively attractive and unqualified conclusions, fourth hand.Those who are concerned with validity will examine raw data and access much more exten- sive databases by standard methods on the Inter- net on a more comprehensive scale at only second hand level.Those who are not concerned with validity will find a ready substitute for
Parathyroid Adenoma Associated with Neurofibromatosis: Correlative Scintigraphic and Magnetic Resonance Imaging
Authors: PHILIP J. VOGELZANG, ELIZABETH OATES, MARK S. BANKOFF
Journal: Clinical Nuclear Medicine (1989)

Correlative imaging by dual-isotope thailium/lechnetium subtraction scintigraphy, computed tomography, and magnetic resonance imaging demonstrated a pathologically proven parathyroid adenoma in a 62-year-old man with known neurofibromatosis, who presented with hypercalcemia and an elevated parathormone level. The association between neurofibromatosis and primary hyperparathyroldism is discussed.
Long-Term Amphotericin B Therapy for Disseminated Histoplasmosis in Patients with the Acquired Immunodeficiency Syndrome (AIDS)
Authors: David S. McKinsey
Journal: Annals of Internal Medicine (1989)

Study Objective: To assess the efficacy and toxicity of long-term maintenance amphotericin B therapy in preventing relapses after treatment in patients with the acquired immunodeficiency syndrome (AIDS) and disseminated histoplasmosis. Design: Open, nonrandomized pilot study. Setting: Three private, university-affiliated community hospitals. Patients: We studied 22 consecutive patients with disseminated histoplasmosis and human immunodeficiency virus (HIV) infection. Sixteen patients completed the study, 5 patients died before completing the initial intensive phase of treatment, and 1 patient received a different treatment regimen. Interventions: Seven patients were treated with an initial intensive course of 1000 mg of amphotericin B, followed by weekly infusions of 50 to 80 mg until a cumulative dose of 2000 mg was attained; biweekly infusions of 50 to 80 mg were then continued indefinitely. Nine patients received an initial amphotericin B course of 2000 mg followed by weekly infusions of 80 mg. Measurements and Main Results: Of the 7 patients in the 1000-mg intensive regimen group, 6 patients have survived without clinical or laboratory evidence of a histoplasmosis relapse, and 1 died of unrelated causes. Of the 9 patients in the 2000-mg intensive regimen group, 7 patients have survived, 1 patient died of a histoplasmosis relapse, and 1 patient died of other causes. Thus, 13 of 14 patients (93%) who did not die of other causes remained relapse-free. The median follow-up period was 14 months (range, 2 to 23 months). No apparent differences in outcome were observed between patients treated with weekly maintenance regimens and those treated with biweekly maintenance regimens. Sixty-three percent of patients developed intravascular device-related complications. Conclusions: Long-term, intermittent maintenance amphotericin B therapy in HIV-infected patients with disseminated histoplasmosis is well tolerated and is highly effective in suppressing relapses after treatment.
Abstract 18209: The Effect of CaMKIIdelta Knockout on Cardiac E-C Coupling in Heart Failure
Authors: Dongwu Lai, Arnaud Guilbert, Jun Cheng, Lin Xu, Hyun Joung Lim, Yibing Nong, Johannes Backs, Eric Olson, Yanggan Wang
Journal: Circulation (2010)

Background:  CaMKII plays an important role in regulating cardiac excitation-contraction (E-C) coupling. Excessive CaMKII activation is linked to the development of cardiomyopathy and dysfunction of E-C coupling. Thus, CaMKII has been proposed to be a therapeutic target.   Objective:  we studied the effects of chronic CaMKII inhibition on cardiac Ca2+ handling and cell twitch in heart failure (HF) ventricular myocytes.   Method and Results:  Pressure-overload HF was produced in the wild type (WT) and CaMKIIdelta knockout (KO) mice by severe thoracic aortic banding (sTAB). HF mice were selected by the criteria of left ventricular (LV) ejection fraction (EF)    Conclusions:  This is the first model of HF with genetic CaMKII inhibition. Chronic inhibition of CaMKII reduces SR Ca2+ leak and increases SR Ca2+ contents and contractility in HF LV but aggravates cellular relaxation, especially at fast pacing rate. These results support the strategy of CaMKII inhibition in HF but also implicate physiologic level of CaMKII activity in maintaining normal ventricular relaxation.
Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C
Authors: Hans L. Tillmann, Keyur Patel, Andrew J. Muir, Cynthia D. Guy, Josephine H. Li, Xiang Qian Lao, Alexander Thompson, Paul J. Clark, Stephen D. Gardner, John G. McHutchison, Jeanette J. McCarthy
Journal: Journal of Hepatology (2011)
QT dynamicity: a prognostic factor for sudden cardiac death in chronic heart failure
Authors: Atul Pathak, Daniel Curnier, Joëlle Fourcade, Jéme Roncalli, Phyllis K. Stein, Patricia Hermant, Marc Bousquet, Pierre Massabuau, Jean-Michel Sénard, Jean-Louis Montastruc, Michel Galinier
Journal: European Journal of Heart Failure (2005)
Outcome of Patients With HIV Infection and Decreased Consciousness or Recurrent Seizures
Authors: Douglas J. Redosh
Journal: JAMA (1995)

To the Editor.  —Dr Bedos and colleagues 1 make a noble attempt to determine prognosis for  patients with human immunodeficiency virus (HIV) infection. However, I take issue with the term neurological  which seems to imply that   can be defined as simply as congestive heart failure, renal failure, or liver failure. The nervous system is highly complex and physicians are sufficiently sophisticated with determining dysfunctions of individual subsystems of the nervous system. The term neurological failure is a misnomer.  The authors have defined   as altered consciousness and/or convulsions requiring intensive care unit (ICU) management. Clearly, the patient who is comatose or stuporous with a profound encephalopathy would meet the definition. But what about a patient with a mild dementia who has a generalized tonic/clonic seizure with a prolonged postictal period, or a patient who is aphasic or develops a hemianopsia or hemiparesis? These lesions may
Isolation and partial characterization of a specific alpha-fetoprotein receptor on human monocytes.
Authors: Y Suzuki, C Q Zeng, E Alpert
Journal: Journal of Clinical Investigation (1992)

Since a large body of data has suggested a significant role for alpha-fetoprotein (AFP) in the regulation of the immune response at a number of levels, we examined the possibility of a specific receptor for AFP on the immune recognition cell, the monocyte/macrophage. Microscopic autoradiography exhibited an obvious binding of AFP almost exclusively on human peripheral monocytes but not on lymphocytes. In a human monocyte cell line (U937) Scatchard plot analysis indicated the presence of two distinct AFP-specific binding sites with a Kd of 5 x 10(-11) M, 49 binding sites per cell, and 2.5 x 10(-7) M, 7,800 binding sites per cell. 125I-ASD-AFP, AFP-radiolabeled bifunctional photoactivatable thio-cleavable cross-linker, was used to isolate the AFP binding protein from U937 cells. After ultraviolet photoactivation, 125I-sulfosuccinimidyl 2-(p-azido-salicylamido)ethyl-1,3'-dithiopropionate was covalently linked to the putative receptor. Autoradiography of SDS gradient PAGE under reducing conditions showed a major radiolabeled band at between 62 and 65 kD. To confirm the specificity of the finding, recombination of AFP with the isolated receptor was examined in artificially reconstituted membrane vesicles, which also resulted in a single band at approximately 62-65 kD by SDS-PAGE autoradiography. From the data above, we concluded that human monocytes possess a specific AFP binding protein on the membrane, a putative receptor, which may be involved with the physiological regulation of the immune response.
Low Plasma Prolactin Levels in Patients with Functional Dyspepsia
Authors: Bo H. Jonsson, Töres Theorell
Journal: Psychotherapy and Psychosomatics (1999)

&lt;i&gt;Background:&lt;/i&gt; The purpose was to compare the levels and patterns of plasma cortisol and prolactin in patients with functional dyspepsia (FD) during a controlled laboratory experiment. &lt;i&gt;Method:&lt;/i&gt; 25 patients (12 men, 13 women), aged 24–50, with recurrent FD, and 25 pair-wise gender- and age-matched community control subjects were studied at a gastroenterological laboratory in a Swedish university hospital. In an experiment, after a rest period, subjects were studied during a neutral interview and a stress interview. Before and during interventions, blood samples were drawn for later peptide analyses. The main outcome measures were the Gastrointestinal Symptom Rating Scale, heart rate, blood pressure, plasma cortisol and prolactin. &lt;i&gt;Results:&lt;/i&gt; Mean plasma cortisol concentration correlated negatively with diarrhoea symptoms (partial correlation; p &lt; 0.01). The level of plasma proclatin (µg/l) was significantly lower (paired t test; p &lt; 0.01) in the patient group (mean = 3.34, CI: 2.75–3.93) compared to the control group (mean = 4.70, CI: 3.63–5.78). During the stress interview, prolactin increased significantly in both groups. When the whole sample was divided according to degree of reflux symptoms, those with high reflux symptomatology had lower prolactin (ANCOVA with covariates for group, gender, age, body mass index and smoking; p &lt; 0.05). &lt;i&gt;Conclusion:&lt;/i&gt; Plasma prolactin concentration was significantly lower in FD patients compared to a matched control group. A high degree of reflux symptoms was significantly associated with inhibition of the prolactin increase during a stress interview.
Th1 cytokine-induced downregulation of PPARγ in human biliary cells relates to cholangitis in primary biliary cirrhosis
Authors: Kenichi Harada, Kumiko Isse, Takashi Kamihira, Shinji Shimoda, Yasuni Nakanuma
Journal: Hepatology (2005)

Peroxisome proliferator-activated receptor-γ (PPARγ) is known to inhibit the production of proinflammatory cytokines. In Th1-predominant diseases, PPARγ ligands can ameliorate clinical severity by downregulating the expression of proinflammatory cytokines. Primary biliary cirrhosis (PBC) is characterized by chronic destructive cholangitis with a Th1-predominant cytokine milieu. Unusual immune responses to infectious agents are suspected to underlie its etiopathogenesis. We examined the significance of PPARγ in biliary inflammation in connection to PBC. To this end, we performed immunohistochemistry, quantitative polymerase chain reaction, and nuclear factor-kappaB (NF-κB) DNA-binding assays to clarify the intrahepatic distribution of PPARγ and the regulation of PPARγ by inflammatory cytokines and PPARγ ligand in five cultured biliary cell lines including one derived from PBC liver. In liver specimens from patients with PBC, PPARγ protein was ubiquitously expressed in intrahepatic biliary epithelium, whereas the expression of PPARγ protein and mRNA was reduced in damaged bile ducts. PPARγ expression in cultured cells was upregulated by interleukin-4 (IL-4; Th2-type), but downregulated by IFN-γ (Th1-type). PPARγ ligand negatively modulated lipopolysaccharide-induced NF-κB activation. Moreover, this inhibitory effect of PPARγ ligand was attenuated by pretreatment with IFN-γ. In conclusion, PPARγ may be important to maintain homeostasis in the intrahepatic biliary epithelium, and its reduction in the bile ducts of PBC liver may be associated with the Th1-predominant milieu and with the development of chronic cholangitis in PBC. Immunosuppression using PPARγ ligands may be of therapeutic benefit to attenuate biliary inflammation in PBC. (HEPATOLOGY 2005;41.)
Aggression: Culture and Psychosomatic Medicine
Authors: Nicholas Destounis
Journal: Psychotherapy and Psychosomatics (1974)

We need more comparative transcultural studies in order to determine the aetiological factors of aggression and psychosomatic disorders. We must prepare ourselves with the demands of the technological advances of the year 2000 by setting priorities in the field of biomedical and social research, and by introducing a new system of values in accordance with the Ecological Realities of our era. We must develop the capacity to anticipate and foresee crises and meet them head-on, otherwise these changes will create intolerable stresses leading into anxiety, aggression, violence and all kinds of psychosomatic disorders.
831-4 Sustained upregulation of chemokine and its receptor genes associated with matrix metalloproteinase overexpression in human carotid plaque rupture: Results from a quantitative study with real-time reverse transcriptase-polymerase chain reaction-method
Authors: Masakazu Yamagishi, Takeo Higashikata, Toshio Higashi, Izumi Nagata, Hatsue Ishibashi-Ueda, Hitonobu Tomoike, Aiji Sakamoto
Journal: Journal of the American College of Cardiology (2004)
Development and Validation of a Predicting Model of All-Cause Mortality in Patients With Type 2 Diabetes
Authors: Salvatore De Cosmo, Massimiliano Copetti, Olga Lamacchia, Andrea Fontana, Michela Massa, Eleonora Morini, Antonio Pacilli, Stefania Fariello, Antonio Palena, Anna Rauseo, Rafaella Viti, Rosa Di Paola, Claudia Menzaghi, Mauro Cignarelli, Fabio Pellegrini, Vincenzo Trischitta
Journal: Diabetes Care (2013)

OBJECTIVE To develop and validate a parsimonious model for predicting short-term all-cause mortality in patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS Two cohorts of patients with T2DM were investigated. The Gargano Mortality Study (GMS, n = 679 patients) was the training set and the Foggia Mortality Study (FMS, n = 936 patients) represented the validation sample. GMS and FMS cohorts were prospectively followed up for 7.40 ±2.15 and 4.51 ±1.69 years, respectively, and all-cause mortality was registered. A new forward variable selection within a multivariate Cox regression was implemented. Starting from the empty model, each step selected the predictor that, once included into the multivariate Cox model, yielded the maximum continuous net reclassification improvement (cNRI). The selection procedure stopped when no further statistically significant cNRI increase was detected. RESULTS Nine variables (age, BMI, diastolic blood pressure, LDL cholesterol, triglycerides, HDL cholesterol, urine albumin-to-creatinine ratio, and antihypertensive and insulin therapy) were included in the final predictive model with a C statistic of 0.88 (95% CI 0.82–0.94) in the GMS and 0.82 (0.76–0.87) in the FMS. Finally, we used a recursive partition and amalgamation algorithm to identify patients at intermediate and high mortality risk (hazard ratio 7.0 and 24.4, respectively, as compared with those at low risk). A web-based risk calculator was also developed. CONCLUSIONS We developed and validated a parsimonious all-cause mortality equation in T2DM, providing also a user-friendly web-based risk calculator. Our model may help prioritize the use of available resources for targeting aggressive preventive and treatment strategies in a subset of very high-risk individuals.
A comparison of ultrasonography and liver biopsy in the assessment of metho-trexate-induced hepatotoxicity in patients with psoriasis
Authors: J.A. Miller, H.J. Dodds, W.R. Lees, P.N. Anderson, G.M. Levene, D.D. Munro, J.D. Kirby
Journal: British Journal of Dermatology (1983)
Is exposure to a patient with Crohn's disease an environmental factor for developing the disease? Reply
Authors: M ALIC;, J D SODERHOLM, G OLAISON, R SJODAHL
Journal: Gut (1999)

Editor,—A recent study of intestinal permeability in patients with Crohn’s disease, their spouses, and first degree relatives, has concluded that baseline permeability is influenced by environmental factors, whereas permeability provoked by acetylsalicylic acid is genetically determined ( Gut 1999; 44 :96–100). The significance of increased intestinal permeability is still unclear, but animal models show that it may be an early event in the inflammatory process, suggesting that environmental and hereditary factors interact in the pathogenesis of Crohn’s disease.

This study also observed that baseline permeability in relatives who were not living with the patient with Crohn’s disease at the time of diagnosis, or at the time of the permeability test, was considerably less abnormal than that of relatives who lived with the patient. Similarly, a subcategory of spouses who had lived with their Crohn’s disease partners since before diagnosis, had a higher percentage of increased permeability than other spouses.

Previously, increased occurrence of Crohn’s disease in a patient’s relatives has been assumed to be indicative of genetic predisposition, and has not been linked to frequency of contact. A study of clusters of cases from the same family suggested that, based on a temporal succession of presentations, an infectious microorganism might be …
Autoimmunity to La (SS-B) in vitro is related to HLA-DR3 in healthy subjects.
Authors: P J Venables, S Rigby, P A Mumford, J Markwick, R N Maini
Journal: Annals of the Rheumatic Diseases (1988)

In patients with Sjögren9s syndrome 50-90% of those who have anti-La (SS-B) in their serum are HLA-DR3 positive. To investigate the relation between DR3 and anti-La antibody production 18 healthy subjects were divided into nine pairs, each matched for age and sex, containing one DR3 positive individual and one with a different DR type. Peripheral blood mononuclear cells from each pair were cultured with varying doses of pokeweed mitogen and supernatants from nine day cultures assayed for antibodies to La, nRNP/Sm, and DNA by enzyme linked immunosorbent assay (ELISA) using purified antigens. In each case peak anti-La secretion was greater in the DR3 positive subject than in the matched DR3 negative individual; in contrast, there was no consistent difference in levels of anti-DNA or anti-nRNP/Sm secretion. This specificity of enhanced autoantibody response in healthy individuals after polyclonal activation suggests that anti-La production may be under the control of genes linked to DR3.