tbuckley/cabot-search huggingface dataset:
IT-13 * IPILIMUMAB FOR RECURRENT HIGH-GRADE GLIOMA: A SINGLE-INSTITUTION CASE SERIES
Authors: Jethro Hu, John Yu, Keith Black, Jeremy Rudnick
Journal: Neuro-Oncology (2014)

BACKGROUND: The anti-CTLA-4 monoclonal antibody ipilimumab is a potent immune modulator. However, experience treating high-grade glioma with ipilimumab is limited. METHODS: In this single-institution consecutive case series, we identified 7 patients with recurrent grade 3 (one patient) and grade 4 (6 patients) glioma who were treated with ipilimumab off-label between June 2012 and April 2014. RESULTS: Age at treatment: 39 to 66 years. Number of infusions: 1-6. Number of recurrences prior to starting ipilimumab: 1-5. Five patients received additional treatment in conjunction with ipilimumab, including 4 who received bevacizumab. Time to progression for the 6 glioblastoma patients: 1.1 mo, 1.2 mo, 2.7 mo, 2.8 mo, 6 mo, 19.5 mo. One patient (with anaplastic astrocytoma) is recurrence-free 3.2 months from treatment initiation. This patient, who has not received concurrent therapy, has had stable disease by RANO criteria, with improvement in FLAIR abnormality, steroid requirement, and functional status. Three patients have died, with survival of 1.3 mo, 2.2 mo, and 5.3 mo. Four patients are still alive at 3.2 mo, 3.7 mo, 13.3 mo, and 23.3 mo follow-up. One patient underwent repeat resection 3 months following treatment initiation, but no evidence of progressive disease was found. Increased granzyme B expression, suggestive of an immune response, was found on immunohistochemistry. Autoimmune-related adverse effects were grade 2 at maximum, and manageable with steroids. CONCLUSION: This case series highlights the potential use of ipilimumab for patients with recurrent high-grade glioma. Though optimal use has yet to be defined, a subset of patients do appear to benefit from treatment. Cases of radiographic response, clinical improvement, and evidence of immune response by pathology have all been seen. Some patients do well even beyond initial progression, a phenomenon that has been observed with other immunotherapies.
Paying Physicians Promptly
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A DRESSING FOR HEMATOMA OF THE EAR
Authors: L. K. Ferguson
Journal: JAMA (1933)

Hematoma of the ear is seen very frequently at the Surgical Out-Patient Department, and at the Student Health Service of the University of Pennsylvania, where wrestlers and boxers of the university squads are cared for. These hematomas are often treated soon after they appear and while the blood is still liquid, so that aspiration is an easy procedure in most cases. The more difficult part of the treatment is the application of a pressure dressing that will prevent recurrence. Although textbooks state that a snug bandage over the ear is sufficient, my experience has been that recurrence almost invariably takes place with such treatment. Some authors have suggested the use of plaster molded pressure bandages. These have been found to be cumbersome, and many students are content to have a cauliflower ear rather than to wear a large dressing that surrounds the head. A dressing is here presented that has
Prognostic Significance of Serial Changes in Left Ventricular Mass in Essential Hypertension
Authors: Paolo Verdecchia, Giuseppe Schillaci, Claudia Borgioni, Antonella Ciucci, Roberto Gattobigio, Ivano Zampi, Gianpaolo Reboldi, Carlo Porcellati
Journal: Circulation (1998)

Increased left ventricular (LV) mass predicts an adverse outcome in patients with essential hypertension. The purpose of this study was to determine the relation between changes in LV mass during antihypertensive treatment and subsequent prognosis.Procedures including echocardiography and 24-hour ambulatory blood pressure (BP) monitoring were performed in 430 patients with essential hypertension before therapy and after 1217 patient-years. Months or years after the follow-up visit, 31 patients suffered a first cardiovascular morbid event. The patients with a decrease in LV mass from the baseline to follow-up visit were compared with those with an increase in LV mass. There were 15 events (1.78 per 100 person-years) in the group with a decrease in LV mass and 16 events (3.03 per 100 person-years) in the group with an increase in LV mass (P=.029). In a Cox model, the lesser cardiovascular risk in the group with a decrease in LV mass (hazard ratio [HR], 0.46; 95% CI, 0.22 to 0.99) remained significant (P=.04) after adjustment for age (HR, 1.06; 95% CI, 1.03 to 1.10; P=.0008) and baseline LVH at ECG (HR, 3.85; 95% CI, 1.52 to 9.78; P=.012). In that model, baseline LV mass bordered on statistical significance (HR, 1.01; 95% CI, 1.00 to 1.03; P=.06). In the subset with LV mass > 125 g/m2 at the baseline visit (26% of subjects), the event rate was lower among the subjects who achieved regression of LVH than in those who did not (1.58 versus 6.27 events per 100 person-years; P=.002). This difference held in the multivariate analysis (HR, 0.18; 95% CI, 0.05 to 0.68).In essential hypertension, a reduction in LV mass during treatment is a favorable prognostic marker that predicts a lesser risk for subsequent cardiovascular morbid events. Such an association is independent of baseline LV mass, baseline clinic and ambulatory BP, and degree of BP reduction.
THE PATHOGENICITY OF GIARDIA (LAMBLIA) INTESTINALIS TO MEN AND TO EXPERIMENTAL ANIMALS
Authors: H. B. Fantham, A. Porter
Journal: BMJ (1916)

INTRODUCTION.WHILE British troops were in Gallipoli, a number of men contracted various forms of dysentery or diarrhoea, and severe cases occurred.Among the men invalided to England a number were found to be infected with Giardia (Lamiblia) intestinalis, and some harboured no other dysentery-producing organism.We personally found 187 cases of pure lambliasis among 1,305 patients.Similar cases of pure lambliasis lhave occurred on the western front, while from the various war zones patients with mixed infections have been common.The patlhogenicity of Giardia (Lamblia) intestinal'i8 has been disputed in certain quarters.We have always believed that the organism was pathogenic, and published the same in 1915 and 1916.We here give our personal evidence, based on our observations of pure cases of lambliasis in man and of some experiments with human Lamblia on animals.We may say at once tllat in both human and animal lambliasis stools, as well as at post-mortem examinations, erosion and distortion of the intestinal epithelial cells occurred, owing to the direct suctorial action of the flagellate Lamblia.HUMAN CASES.
The Chief Complaint
Authors: Harry B. Soletsky
Journal: JAMA (1981)

To the Editor.—  I believe an alternate perspective should be considered regarding Dr Hardison's editorial Whatever Happened to the Chief Complaint? (1981;245:1942). Certainly the descriptions mentioned, where a chief complaint is determined by some other reason for admission (such as cardiac catheterization, another course of chemotherapy, or disposition problem), should also bring to mind some alternate thoughts in medical care. As a medical student I was taught to ask for chief complaints and take extensive histories and physicals; these were usually followed by comprehensive laboratory tests. The intent was to do a workup from stem to stern. Such procedures are not an excuse for poor diagnostic ability but more an acknowledgment that a hospital is now a proper place to take care of one particular problem. I believe such approaches can be extremely cost-effective: it can certainly be expensive if one cannot leave the hospital without every complaint being totally
O7.01 * RESPONSE ASSESSMENT IN NEURO-ONCOLOGY (RANO) CRITERIA FOR BRAIN METASTASES
Authors: P. Y. Wen, E. Q. Lee, M. Van Den Bent, R. Soffieti, M. Bendszus, M. Mehta, B. Baumert, M. Vogelbaum, S. M. Chang, N. U. Lin
Journal: Neuro-Oncology (2014)

Currently, there are no standard criteria for evaluating response to therapy in patients with brain metastases.An international multidisciplinary group, The Response Assessment in Neuro-Oncology (RANO) Metastatic Working Group has proposed a RANO-Brain Metastases (RANO-BM) Criteria is based on a modification of RECIST 1.1 criteria and uses unidimensional measurements.Since the CNS is considered as a separate compartment.CNS response will be scored independent of extracranial response.Measurable Overall survival
Functional histochemistry of the small bowel mucosa in malabsorptive syndromes
Authors: H. M. Spiro, M. I. Filipe, J. S. Stewart, C. C. Booth, A. G. E. Pearse
Journal: Gut (1964)

EDITORIAL SYNOPSIS This study shows that in the flat mucosa of the small intestine in patients with idiopathic steatorrhoea many enzymes are lacking in normal activity but the histochemical reactions tend to be stronger in those patients who have had a gluten-free diet.on August 2,
On the detection of newer Epo forms in serum and urine using isoelectric focusing
Authors: Joris Delanghe, Mathieu Bollen, Monique Beullens
Journal: American Journal of Hematology (2008)

Induction of integrin b 1 expression in bone marrow cells after chemotherapy correlates with the overexpression of lung resistance protein and poor outcome in patients with multiple myelomaTo the Editor: Acquired drug resistance continues to be one of the major obstacles hindering the successful treatment of multiple myeloma (MM).Expression of one or several multidrug resistance (MDR) genes such as lung resistance protein (LRP) and MDR1 is associated with resistance to
FACTOR PREVALENCE, GENDER DISTRIBUTION AND CLINICAL OUTCOMES OF A YOUNG COHORT OF PATIENTS WITH ST SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION IN A LARGE SAFETY NET COUNTY HOSPITAL
Authors: Carlos Alberto Rueda Rios, Camilo Gomez, Marian Calfa, Libardo Rueda, Nohora X. Torres, Cesar Mendoza-Trauco, Juan Zambrano, Carlos Alfonso, Alansari Yahaia, Eduardo De Marchena, Alexandre Ferreira
Journal: Journal of the American College of Cardiology (2014)
Postoperative Deep Venous Thrombosis
Authors: A. Singer
Journal: BMJ (1970)

MEDICALJOUNL mEq/1.).It would therefore seem sensible to attempt to minimize the side effects experienced by the patient by making a special effort to keep the serum lithium in the lower therapeutic ranges.To reduce the peak rise to a minimum the lithium salt should be given in small divided doses at six-hourly intervals.Alternatively the use of a slow release compound might overcome this latter difficulty.One of the practical problems of deter- mining dosage by serum levels is that flame photometer estimations are only performed at selected centres.In Salford, where the estimations are carried out at only one of the hospital laboratories, we have found by a "split sample technique" that whole blood samples kept at room temperature for 24-48 hours give a valid result.If the serum is separated and kept at 4' C., apart from the duration of transportation, a valid reading can be obtained over a longer period.-Iam, etc.,
A Prospective Study on the Safety of Immunotherapy in Children with Severe Asthma
Authors: P. Aa. Østergaard, P. H. Kaad, T. Kristensen
Journal: Allergy (1986)

One hundred and six of 503 (21 %) consecutive children with asthma, who from 1979 to 1983 commenced hyposensitization therapy, were prospectively studied on the safety of immunotherapy. More than 80% of the patients completed therapy without side effects. Thirteen patients were withdrawn from hyposensitization due to moderate and predictable, but intolerable, side effects such as asthma/rhinitis, urticaria and subcutaneous nodules and hypersensitivity to aluminium. However, more alarming was the outcome in six children, who after an uneventful course of immunotherapy and after several months on maintenance therapy, suddenly, 5 to 20 min (mean 10 min) following an earlier tolerable allergen injection, developed severe, anaphylactic reactions, in three of them nearly fatal. Mould extracts were responsible for the most frequent and serious side effects ( Alternaria iridis/alternate , 3 patients, Cladosporium herbarum. 8 patients). Furthermore, serious, but not immediately life‐threatening, anaphylactic reactions occurred in two children treated with Phleum pretense On the other hand, hyposensitization with Dermatophagoides pteronyssinus was very well tolerated.
Changing overall workload in neonatal units.
Authors: D J Field, A D Milner, I E Hopkin, R J Madeley
Journal: BMJ (1985)

An epidemiological study was carried out in the current Nottingham health district to determine changes in both neonatal unit workload and in the infants requiring neonatal care during two study periods. All admissions for 1977 and again for the 12 months 1 April 1983 to 31 March 1984 were reviewed. Total numbers of admissions have shown roughly a 50% reduction because of a more rigorous admission policy locally. The admissions of infants of 33 weeks9 gestation or less have shown a significant increase, while the overall survival of infants less than 33 weeks9 gestation has improved.
Risk Factors in Childhood Epilepsy
Authors: Robert G. Ziegler
Journal: Psychotherapy and Psychosomatics (1985)

Seizure frequency, seizure type and the associated presence of learning disabilities contribute to the heightened psychiatric risk noted in childhood epilepsy. Each of these factors demands some modification in the treatment program. Psychoeducational components of traditional psychodynamic therapy are highlighted; stress reduction programs need to be implemented and ongoing grief work for child and family managed. Specific educational plans for the treatment of learning disabilities should be formulated in order to decrease their impact on the child's self-esteem. Where learning disabilities and attentional disorders coexist, both stimulant medication and behavior modification techniques are warranted.
Marketing Medicine to Today's Consumer
Authors: Barbara W. Nowak
Journal: JAMA (1979)

IN THE not too distant past, the popular public attitude toward physicians was one of respect bordering on reverence. The individual physician's reputation was enhanced by his association with the medical profession at large. Today a physician may still build a fine personal reputation—but it is in spite of current public opinion of the medical community. Physicians are suffering from a tarnished image. This may seem a frivolous concern compared with the weightier health care issues that are part of our national dialogue. But image is a serious matter and may, in fact, be at the root of many of the profession's legislative woes. The shift in consumer attitudes toward the medical profession has been dramatic. But why has the trend developed, and can it be reversed? Although other variables have played their part, the overriding reason for the change has been that physicians have stopped communicating. The obvious remedy
Regulating the Tumor Suppressor Gene <b> <i>Maspin</i> </b> in Breast Cancer Cells
Authors: Zhila Khalkhali-Ellis, Abby L. Christian, Dawn A. Kirschmann, Elijah M. Edwards, Maryam Rezaie-Thompson, Mohammad A. Vasef, Lynn M. Gruman, Richard E. B. Seftor, Laura E. Norwood, Mary J. C. Hendrix
Journal: Clinical Cancer Research (2004)

Abstract Purpose: Mammary epithelial cells and the majority of breast cancer tumors require estrogen for continued growth. Antiestrogen therapy alone, or in combination with other drugs, has long been a common procedure for breast cancer treatment and prophylaxis. Thus, there is a critical need to elucidate the mechanism(s) of action of antiestrogen treatment, especially for patients who are at risk of breast cancer development or who are currently receiving hormone therapy. In this study, we examined the ability of hormones to regulate the expression of a tumor suppressor gene, maspin, which is a serine protease inhibitor (serpin) that plays an important role in mammary gland development and is silenced during breast cancer progression. Specifically, our hypothesis tested the clinical efficacy of tamoxifen to regulate maspin expression. Experimental Design: We used maspin promoter luciferase reporter plasmids that were transfected into normal human mammary epithelial (HMEC1331) and MCF-7 breast cancer cells, followed by determination of the effect of hormones and their antagonists on maspin promoter activity. At the protein level, cytosolic fractions from both cell types before and after hormone treatment were subjected to Western blot analysis to determine maspin level. Results and Conclusions: Our studies revealed that the antiestrogen tamoxifen induces maspin promoter activity. Interestingly, antiandrogen flutamide could also induce maspin in both cell lines tested. These observations were further confirmed in patient tissues. These novel findings provide a new mechanism of action for tamoxifen under normal and pathological conditions. More significantly, these findings could have a potential impact on future therapeutic intervention strategies for breast cancer.
Recurrent haemoptysis in a young woman: a case of a malignant haemangiopericytoma of the lung
Authors: T B Rothe, W Karrer, J-O Gebbers
Journal: Thorax (1994)

Abstract A 36 year old woman presented with mild recurrent haemoptysis and cough persisting over several months caused by a malignant haemangiopericytoma of the right lung.
Pulmonary Embolism: Mechanism and Management
Authors: Chilton Crane
Journal: JAMA (1966)

This book on pulmonary embolism is essentially a review of the major world literature on this subject. Much of the recent experimental literature on the anatomic, physiological, pharmacological, and biochemical considerations of pulmonary embolic disease, is well analyzed and convincingly evaluated. But the chapters discussing the diagnosis, prevention, and treatment of pulmonary embolism—surely the heart of the book to many readers —fall down badly. The volume suggests strongly that the author has had little opportunity to take responsibility for the diagnosis and management of patients with venous thromboembolism.  The drawbacks and weaknesses of any technique for diagnosis, prevention, or treatment of pulmonary embolism are often given equal weight with the advantages, to the point where diagnosis seems universally doubtful, prevention probably futile, and treatment often either too risky or too unpromising to carry through. Thus the usefulness and safety of pulmonary angiography in demonstrating chunks of thrombus in the main
Effects of balloon size on immediate hemodynamic results of percutaneous mitral valvuloplasiy (PMV) in the M-heart registry
Authors: Howard C. Hermmann, J.Patrick Kleaveland, James A. Hill, Michael Cowley, Sheldon Goldberg, Steve Heilbrunn, John W. Hirshfeld, Charles R. Lambert, James R. Margolis, Jose C. Martin, Michael A. Nocero, George Vetrovec, Hall B. Whitworth, Andrew Zalewski, Carl J. Pepine
Journal: Journal of the American College of Cardiology (1990)
A LABILE INTRANUCLEAR RNA ASSOCIATED WITH THE DEVELOPMENT OF ADENOVIRUSES
Authors: Heather Donald Mayor
Journal: The Journal of Experimental Medicine (1964)

The nucleic acids produced intracellularly during the replication cycles of both DNA and RNA viruses can now be identified rapidly using a sensitized procedure based on staining with the fluorochrome acridine orange. Cellular DNA, viral DNA (both single and double stranded forms), cellular RNA, and RNA arising as a result of viral stimulus can be differentiated. The intracellular development of virus specific DNA, RNA, and protein has been studied in monkey kidney cells infected with adenoviruses types 3 and 7. It has been possible to detect a labile RNA in the nucleus from 16 to 20 hours after inoculation. When the cultures are treated with puromycin at this time, this RNA can be accumulated under certain conditions in the nucleus and demonstrated cytochemically. At the same time the production of specific viral protein as determined by staining with fluorescein-labeled antibodies is markedly inhibited. However, intranuclear double stranded DNA continues to be formed for a time. When puromycin is added to the system early in the eclipse period virus-specific DNA and labile RNA cannot be detected.
Changes in perinatal conditions selected for neonatal immaturity
Authors: Sonia Ragir
Journal: Behavioral and Brain Sciences (2001)

The mechanics of walking restructured the pelvis and narrowed the birth-canal that selected for delays in skeletal ossification. Prolonged phases of fetal maturation increased the mass and volume of the brain relative to adult body-size, as encephalization increased. Thus, bipedal- walking and episodic increases in hominine body size probably triggered selection for neonatal skeletal immaturity that led to encephalization.
Ocular cicatricial pemphigoid associated with practolol therapy
Authors: TH.VAN JOOST, R.A. CRONE, A.D. OVERDIJK
Journal: British Journal of Dermatology (1976)

The clinical and laboratory findings in a case of serious cicatricial blistering of the ocular mucous membrane were comparable with those found in cicatricial pemphigoid (ocular mucous membrane pemphigoid).
Exposure to Rosiglitazone and Fluoxetine in the First Trimester of Pregnancy
Authors: June-Seek Choi, Jung-Yeol Han, Hyun-Kyong Ahn, Joong-Sik Shin, Jae-Hyug Yang, Mi-Kyoung Koong, Alejandro A. Nava-Ocampo
Journal: Diabetes Care (2006)

Rosiglitazone is a thiazolidinedione oral hypoglycemic drug that seems to be a promising alternative not only as an oral hypoglycemic agent but also for women with polycystic ovary syndrome. However, information regarding exposure to rosiglitazone in pregnancy is limited to two previous case reports. In the first case, a 35-year-old woman was exposed until the 8th week of pregnancy to 4 mg/day rosiglitazone and to glicazide, acarbose, atorvastatin, spironolactone, hydrochlorothiazide, carbamazepine, thiridazine, amitryptiline, chlordiazepoxide, and pipenzolate bromide (1). The second case was a woman exposed to 4 mg/day rosiglitazone between gestational weeks 13 and 17 (2). The two cases delivered normal babies at gestational weeks 36 and 37, …
Nodal staging: Number or site of nodes? How to improve accuracy? Is FNA always necessary? Junctional tumors - what's N and what's M?
Authors: E. Vazquez-Sequeiros
Journal: Endoscopy (2006)

Endoscopic ultrasound (EUS) allows one to identify the presence of lymph nodes in the mid and posterior mediastinum, the perigastric area and the celiac axis region [1]. EUS, by means of endoscopic ultrasound guided fine needle aspiration biopsy (EUS FNA), may also be employed for procurement of a tissue diagnosis in a minimally invasive fashion [1]. This has been proven to be useful in a number of gastrointestinal and pulmonary malignancies. This review article focuses on nodal staging of esophageal cancer and attempts to answer the following questions: 1. Number or site of nodes for nodal staging? How to improve accuracy of nodal staging? 2. Is FNA always necessary? 3. Junctional tumors - what's N and what's M?