Folic Acid Antagonists
Authors: NATHANIEL I. BERLIN
Journal: Annals of Internal Medicine (1963)

Clinical Staff Conference1 December 1963Folic Acid AntagonistsEffects on the Cell and the Patient Combined Clinical Staff Conference at the National Institutes of HealthNATHANIEL I. BERLIN, M.D., DAVID RALL, M.D., J. A. R. MEAD, PH.D., EMIL J FREIREICH, M.D., EUGENE VAN SCOTT, M.D., ROY HERTZ, M.D., MORTIMER B. LIPSETT, M.D.NATHANIEL I. BERLIN, M.D., DAVID RALL, M.D., J. A. R. MEAD, PH.D., EMIL J FREIREICH, M.D., EUGENE VAN SCOTT, M.D., ROY HERTZ, M.D., MORTIMER B. LIPSETT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-931 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Nathaniel I. Berlin: Since the introduction in 1947, of the folic acid antagonists for treatment of neoplastic diseases, there have been a number of studies designed to determine the mechanism of their action and their role in cancer chemotherapy. The papers selected for presentation at this conference were designed to summarize the present knowledge of the folic acid antagonists. To this end, the pharmacology and biochemistry are being presented together with reports of therapeutic usefulness in acute leukemia, diseases of the skin, and choriocarcinoma. While excellent therapeutic effects can be achieved, it is with some cost in toxicity. For...References1. PETERING HG: Folic acid antagonists. Physiol. Rev. 32: 197, 1952. CrossrefMedlineGoogle Scholar2. WERKHEISER WC: Biochemical, cellular and pharmacological action and effects of the folic acid antagonists. Cancer Res. 23: 1227, 1963. Google Scholar3. FARBERDIAMONDMERCERSYLVESTERWOLFF SLKRDRFJA: Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroylglutamic acid (aminopterin). New Eng. J. Med. 238: 787, 1948. CrossrefMedlineGoogle Scholar4. OLIVERIO VT: Chromatographic separation and purification of folic acid analogs. Anal. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Cancer Institute, National Institutes of Health, United States Public Health Service, Department of Health, Education, and Welfare, Bethesda, Maryland.Requests for reprints should be addressed to Nathaniel I. Berlin, M.D., National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014. 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TURNER, M.D.Zweite wissenschaftliche SitzungThe Effect of Triacetyl Azauridine on Psoriasis*The Normal Trichogram in the Child before the Age of PubertyDrug Synergism in Antineoplastic Chemotherapy 1 December 1963Volume 59, Issue 6Page: 931-957KeywordsBiochemistryCancer chemotherapyCancer treatmentFolic acidMedical servicesPharmacologyPrevention, policy, and public healthSkin diseasesToxic agentsToxicity Issue Published: 1 December 1963 PDF DownloadLoading ...