tbuckley/cabot-search huggingface dataset:
Papillary Thyroid and Squamous Cell Carcinoma in the Same Radioguided Sentinel Lymph Node
Authors: B Guelfucci, D Lussato, S Cammilleri, M Chrestian, M Zanaret, O Mundler
Journal: Clinical Nuclear Medicine (2004)

A 51-year-old man with squamous cell carcinoma of the tongue had lymphoscintigraphy after 28 Mbq Tc-99m sulfur colloid was circumferentially injected around the tumor. Gamma probe localization identified of 2 sentinel lymph nodes (SLN1 and SLN2). After localization on the skin, SLN1 and SLN2 were detected by the handheld gamma probe), they were removed and submitted separately for histologic evaluation, then a complete neck dissection was performed. Histologic analysis of each sentinel lymph node by additional slice techniques (15 slices per block) showed that SLN1 contained both squamous cell carcinoma and metastatic papillary thyroid carcinoma. No cancer was observed in SLN2 or in other removed lymph nodes. This patient illustrates the efficiency of sentinel lymph node radiolocalization with optimal histologic methods in the identification of occult metastases.
Generic Antiretrovirals and HIV Care in the United States
Authors: Renslow Sherer
Journal: Annals of Internal Medicine (2013)

Letters21 May 2013Generic Antiretrovirals and HIV Care in the United StatesRenslow Sherer, MDRenslow Sherer, MDFrom University of Chicago, Chicago, Illinois.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-10-201305210-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In their model of generic ART in the United States, Walensky and colleagues (1) pragmatically accepted the current realities of patent law in this country, as did I in the accompanying editorial. To do otherwise would have been impractical. Dr. Cohn overlooked the attribution of global decreases in HIV death and incidence rates to generic ART in this editorial. Dr. Cohn states correctly that a generic coformulation of efavirenz, lamivudine, and tenofovir has been shown to be pharmacologically and clinically equivalent to the branded version in other countries and that it has, indeed, contributed to these welcome global ...References1. Walensky RP, Sax PE, Nakamura YM, Weinstein MC, Pei PP, Freedberg KA, et al. Economic savings versus health losses: the cost-effectiveness of generic antiretroviral therapy in the United States. Ann Intern Med. 2013;158:84-92. [PMID: 23318310] LinkGoogle Scholar2. Ensig F, Gertstoft J, Helleberg H, Kronborg G, Mathiesen L. Virological response in patients, who for economic reasons, were changed from Atripla to a multi-tablet regimen. In: Program and Abstracts of the Conference on Retroviruses and Opportunistic Infections. 20th Conference on Retroviruses and Opportunistic Infections, Atlanta, Georgia, 3–6 March 2013. Poster 579. Google Scholar3. Columbia University Center for the Study of Human Rights. 25+ Human Rights Documents: International Covenant on Economic, Social, and Cultural Rights. New York: Columbia University Center for the Study of Human Rights; 2005:11. Google Scholar Author, Article, and Disclosure InformationAuthors: Renslow Sherer, MDAffiliations: From University of Chicago, Chicago, Illinois.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-2981. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGeneric Antiretrovirals and the Uncertain Future of HIV Care in the United States Renslow Sherer Generic Antiretrovirals and HIV Care in the United States Jennifer Cohn Metrics 21 May 2013Volume 158, Issue 10Page: 777-778KeywordsAntiretroviral therapyConflicts of interestDeath ratesDisclosureHIVHealth careObservational studiesOpportunistic infectionsPublic policyRetroviruses ePublished: 21 May 2013 Issue Published: 21 May 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The "Unexplained" High Erythrocyte Sedimentation Rate
Authors: B. Ansell, E. G. L. Bywaters
Journal: BMJ (1958)

Routine estimation of the erythrocyte sedimentation rate (E.S.R.) in new patients attending a rheumatism clinic sometimes reveals a value inexplicable in terms of the clinical diagnosis-for example, when the affliction is thought to be of a non-inflammatory nature, such as degenerative joint disease or " psychogenic rheumatism."Such cases often remain diagnostic problems, and we have therefore reviewed all these cases seen over a period of 31 years.It seems to us important to document them, since medical literature in general neglects such patients (although they occur in every clinic) and tends to record only those who can be fitted into well-defined noso- logical categories. Method and MaterialWestergren's (1926) method was employed, and due pre- cautions were taken with regard to contamination of the sample with skin-sterilizing alcohol (Sykes, 1948), to delay before setting-up of the sedimentation tube, to its verticality and cleanliness (Ham and Curtis, 1938), and to the room temperature (Romanus, 1944).From February, 1952, until September, 1955, 51 out of approximately 900 estimations on new patients were found to be above 20 mm. per hour for no good clinical reason.Of these 51 cases 45 were re-examined and the E.S.R. was estimated again within one month of their first visit.In 14 it had returned to normal, so these patients were classi-
P639 SPONTANEOUS SEROCLEARANCE OF HBsAg IN HEPATITIS B VIRUS/HEPATITIS C VIRUS DUALLY INFECTED PATIENTS: A 10-YEAR FOLLOW-UP
Authors: C.-J. Liu, L.-W. Wu, T.-C. Tseng, W.-T. Yang, T.-H. Su, H.-C. Yang, C.-H. Liu, J.-H. Kao, D.-S. Chen, P.-J. Chen
Journal: Journal of Hepatology (2014)
Low-Dose Arsenic Compromises the Immune Response to Influenza A Infection <i>in Vivo</i>
Authors: Courtney D. Kozul, Kenneth H. Ely, Richard I. Enelow, Joshua W. Hamilton
Journal: Environmental Health Perspectives (2009)

BackgroundArsenic exposure is a significant worldwide environmental health concern. We recently reported that 5-week exposure to environmentally relevant levels (10 and 100 ppb) of As in drinking water significantly altered components of the innate immune response in mouse lung, which we hypothesize is an important contributor to the increased risk of lung disease in exposed human populations.ObjectivesWe investigated the effects of As exposure on respiratory influenza A (H1N1) virus infection, a common and potentially fatal disease.MethodsIn this study, we exposed C57BL/6J mice to 100 ppb As in drinking water for 5 weeks, followed by intranasal inoculation with a sub lethal dose of influenza A/PuertoRico/8/34 (H1N1) virus. Multiple end points were assessed postinfection.ResultsArsenic was associated with a number of significant changes in response to influenza, including an increase in morbidity and higher pulmonary influenza virus titers on day 7 post-infection. We also found many alterations in the immune response relative to As-unexposed controls, including a decrease in the number of dendritic cells in the mediastinal lymph nodes early in the course of infection.ConclusionsOur data indicate that chronic As exposure significantly compromises the immune response to infection. Alterations in response to repeated lung infection may also contribute to other chronic illnesses, such as bronchiectasis, which is elevated by As exposure in epidemiology studies.
Effect of antibiotic therapy on nasal nitric oxide concentration in children with acute sinusitis.
Authors: E Baraldi, N M Azzolin, P Biban, F Zacchello
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Recently, it has been demonstrated that paranasal sinuses are an important site of nitric oxide (NO) production in the upper airways. The aim of this study was to evaluate the NO nasal concentration in children with acute maxillary sinusitis before and after treatment with antibiotic therapy. We performed NO nasal measurements in 16 children 4 to 13 yr of age with acute maxillary sinusitis and compared values with 16 age- and sex-matched healthy control subjects. The diagnosis of acute sinusitis was done by clinical signs and symptoms in addition to radiographic examination. NO nasal concentrations were measured by a chemiluminescence analyzer. Nasal NO steady state during oral breathing was recorded. The mean +/- SEM NO nasal concentration in children with sinusitis was 70 +/- 8.7 parts per billion (ppb) and increased significantly to 220 +/- 15 ppb (p < 0.001) after antibiotic therapy (amoxicillin/clavulanate). NO values after recovery from sinusitis were similar to those of healthy control subjects (245 +/- 15 ppb, p = NS). NO nasal measurements were also performed before and after antibiotic treatment in nine children 4 to 12 yr of age with symptoms of upper respiratory tract infection but no symptoms of sinusitis. In these children NO nasal levels were 249 +/- 32 ppb and did not change (p = NS) after antibiotic therapy. We conclude that during acute maxillary sinusitis the concentration of nasal NO is largely decreased, probably because of an impaired flow of NO from the paranasal sinuses, and that NO returns to normal levels after antibiotic therapy.
Microvascular effects of atrial natriuretic peptide (ANP) in man: studies during high and low salt diet
Authors: A Houben
Journal: Cardiovascular Research (1998)

Objective: Infusion of ANP in anephric dogs causes a decrease in cardiac output and a rise in peripheral vascular resistance. This reduced cardiac output is possibly related to increased resistance to venous return generated in the microcirculation by venular constriction. The aim of the present study was to evaluate in healthy volunteers the effects of low-dose ANP infusion on both conjunctival and skin microcirculation during high or low salt diet. Methods: ANP (7.5 ng/kg/min) and placebo were infused (i.v.) for 4 h, in random order on two separate days, in two groups of 10 healthy male volunteers each. One group was studied during high salt (ad libitum), and one group during low salt (55 mmol Na+/24 h) diet. Microvascular density and diameters of both conjunctiva and nailfold were studied using intravital videomicroscopy. Nailfold capillary red blood cell velocity (CBV) was studied using intravital videomicroscopy, and skin (thermoregulatory) blood flow (SBF) was studied using laser-Doppler fluximetry. Results: In the high salt group ANP induced a 43% reduction in basal SBF as compared to an 18% reduction by placebo (P<0.01). Parallel to SBF, ANP significantly reduced CBV (P<0.02). Conjunctival capillary density decreased by 5% during ANP, while it increased by 28% during placebo (P<0.05). No such effects of ANP were observed in the low salt group. Blood pressure and heart rate were not influenced by ANP infusion in either group. Conclusion: Infusion of low doses of ANP into humans on an ad libitum salt diet results in vasoconstriction of the microcirculation, probably on the venular side. The lack of effect of ANP on the microcirculation during low salt diet may be related to a higher vascular tone prior to infusion.
Cytogenetics—An Aid to Histopathology in Malignant Lymphomas
Authors: A. S. D. Spiers
Journal: JAMA (1979)

To the Editor.—  Because of their objectivity, cytogenetic studies are a valuable diagnostic aid in leukemias, myeloproliferative syndromes, 1 and in suspected malignant effusions 2 —conditions where diagnosis is cytological, subjective, and often difficult. Malignant lymphomas often present problems of histological diagnosis, but few reports 3 describe use of cytogenetics as an aid to histopathology. In two of our patients, malignant lymphoma could not be diagnosed histologically, but the diagnosis was supported by cytogenetic findings; in one case this was borne out by clinical events.  Report of Cases.—  Case1.—A 71-year-old man had generalized lymphadenopathy; an inguinal node biopsy specimen was diagnosed as histiocytic lymphoma or malignant histiocytosis. The patient was treated for 13 months with an antineoplastic regimen of cyclophosphamide, vincristine sulfate, prednisone (COP). Afterwards he was well for three years, and then generalized mild lymphadenopathy developed. An axillary node biopsy specimen showed follicular and interfollicular hyperplasia, with numerous
Transmembrane action potentials and the electrocardiogram in rats with renal hypertension
Authors: E. C H KEUNG, R. S ARONSON
Journal: Cardiovascular Research (1981)

The results of previous studies of the relation between the surface electrocardiogram and cellular transmembrane potentials have suggested that the T wave configuration of the ECG is the result of a difference in the duration of endocardial and epicardial action potentials. Ventricular hypertrophy induced by renal hypertension in rats is associated with lengthening of action potential duration and a reproducible decrease in T wave magnitude. Therefore, this model was used to study the relation between the surface T wave configuration and regional differences in action potential duration. ECGs were recorded from hypertensive (HBP) and sham-operated (SHAM) rats. The hearts from these animals were removed and transmembrane action potentials were recorded by standard microelectrode techniques from endocardial and epicardial preparations. We found that the normally peaked T waves seen in the ECG of SHAM rats was reduced by 35% in the ECG of HBP rats. This reduction of T wave magnitude was associated with similar duration of epicardial and endocardial action potentials in HBP rats. However, peaked T wave in SHAM ECG was not accompanied by a significant disparity in the duration of the epicardial and endocardial action potentials. Thus, there is no simple, consistent correlation between surface T wave configuration and regional differences in intracellular action potential duration in rats.
The Name of a Champion
Authors: Adam D. Falchook
Journal: Annals of Internal Medicine (2009)

On Being a Doctor19 May 2009The Name of a ChampionAdam D. Falchook, MDAdam D. Falchook, MDFrom University of Florida, Gainesville, FL 32610.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-10-200905190-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail To get a name can happen but to few; it is one of the few things that cannot be brought. It is the free gift of mankind, which must be deserved before it will be granted, and is at last unwillingly bestowed.—Samuel Johnson, English author, critic, and lexicographer (1709–1784)In my second year of medical school, I entered a neuroscience lecture one September day as the New York Yankees were heading into the World Series. A list of numbers on the chalkboard was arranged in 4 columns that we began to copy down without knowing why, as is often the ... Author, Article, and Disclosure InformationAuthors: Adam D. Falchook, MDAffiliations: From University of Florida, Gainesville, FL 32610.Corresponding Author: Adam D. Falchook, MD, University of Florida, Medical Plaza Clinic, PO Box 100236, Gainesville, FL 32610; e-mail, adam15@ufl.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 May 2009Volume 150, Issue 10Page: 734KeywordsAmyotrophic lateral sclerosisCoronary heart diseaseHospitalizationsMotor neuronsMusclesNeurologyPulmonary functionResidencyScientistsStable coronary artery disease ePublished: 19 May 2009 Issue Published: 19 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Better Living Through Brain Chemistry?
Authors: Brian M. Rees
Journal: JAMA (1989)

To the Editor. —  I read with great interest the article by Dr Wagner 1 proposing that peace through mind/brain science may be an idea whose time has come. An obvious stumbling block is that the perpetrators of violence and belligerent behavior may not be available to be treated medically and/or that the numbers of those treated may not be sufficient to change societal trends.  Recent data point to a technology that addresses these issues. The hypothesis is that the practice of transcendental meditation by a small group of individuals can decrease social conflict in a much larger population of persons who are not in any contact with the meditators. One study 2 reported the effects of such a group in Jerusalem in 1983. An inverse correlation was shown between the size of the meditating group and war deaths and war intensity in neighboring Lebanon, as well as crimes and
Cleansing Enemas after Sodium Polystyrene Sulfonate Enemas
Authors: Kirk V. Shepard
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 May 1990Cleansing Enemas after Sodium Polystyrene Sulfonate EnemasKirk V. Shepard, MDKirk V. Shepard, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-9-711_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:An article by Wootton and colleagues (1) in a recent issue concerned a patient who had necrosis of the colon after he was administered a sodium polystyrene sulfonate suspension enema. A subsequent letter to the Editor by Burnett (2) questioned whether cleansing enemas had been administered to the patient before and after the sodium polystyrene sulfonate suspension enema, as is stated in bold type on the product insert, on the product label, and on the carton (3). In a discussion with one of the authors of this case report, I was told that the patient was not...References1. WoottonRhodesLeeFitts FDWC. Colonic necrosis with Kayexalate-sorbitol enemas after renal transplantation. Ann Intern Med. 1989;111:947-9. LinkGoogle Scholar2. Burnett R. Sodium polystyrene-sorbitol enemas. Ann Intern Med. 1990;112:311-2. LinkGoogle Scholar3. Product Information: Sodium Polystyrene Sulfonate Suspension. Roxane Laboratories, Columbus, Ohio, 1988. [Available from Roxane Laboratories, Inc., P.O. Box 16532, Columbus, OH 43216-6532.] Google Scholar4. LillemoeRomoloHamiltonPenningtonBurdickWilliams KJSLJG. Intestinal necrosis due to sodium polystyrene (Kayexalate) in sorbitol enemas: clinical and experimental support for the hypothesis. Surgery. 1987;101:266-72. Google Scholar5. FlaniganReckardLucas RCB. Colonic complications of renal transplantation. J Urol. 1988;139:503-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Kirk V. Shepard, MDAffiliations: Roxane Laboratories, Inc. Columbus, OH 43216-6532 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGastrointestinal disorders and renal failure: exploring the connectionGastrointestinal drugs 1 May 1990Volume 112, Issue 9Page: 711-711KeywordsColonNecrosisSodium ePublished: 1 December 2008 Issue Published: 1 May 1990 PDF downloadLoading ...
Progress in Infertility
Authors: Norbert Gleicher
Journal: JAMA (1988)

This is the third edition of a text on diagnosis and treatment of infertility. Interestingly, while only seven years intervened between the first and second editions, 13 years passed before the third edition appeared. This is important because it indicates that a completely new book is before us. Aided by 54 contributors, the three editors present 36 chapters in 11 sections of the book. They also include two appendices of previously published ethical considerations concerning new reproductive technologies and artificial insemination. In their introduction, the editors note that "The advances in infertility since the last edition have been truly astonishing." Many of these advances are presented in exceptional form by some of the very individuals who have made this progress possible. Chapters of special excellence include those by Richard L. Sweet on pelvic infections and mycoplasma, two by DeCherney and Naftolin on ectopic pregnancy and diethylstilbestrol, ovarian failure (Joe Leigh
Abstract 1984: A novel logistic regression model for microRNA microarray normalization
Authors: Bin Wang, Paul Howell, Xiaofeng Wang, Xuemin Qian, Kun Huang, Adam Riker, Jingfang Ju, Yaguang Xi
Journal: Cancer Research (2010)

Abstract MicroRNA (miRNA) is a set of newly discovered non-coding small RNA molecules. It regulates gene expression at the translational level through binding to the 3′-UTR of the target gene. Its significant effects have contributed to a number of critical biological events including cell proliferation, apoptosis, development as well as tumorigenesis. High throughput genomic discovery platforms (e.g. microarray) have been employed to evaluate the important roles of miRNAs by analyzing their expression profiling. However, because of the small total number of miRNAs and the absence of well known endorse controls, the traditional normalization methods for messenger RNA (mRNA) profiling analysis could not offer a suitable normalization solution for miRNA analysis. The establishment of new adaptive normalization methods has come to the forefront. In this study, Locked Nucleic Acid (LNA) based miRNA array was employed to profile miRNAs using colorectal cancer cell lines HCT116 under different drug treatments (5FU, CPT-11, and oxaliplatin). We randomly selected approximate 10% of total microRNAs from the microarray (37 miRNAs) and determined their expression patterns using quantitive real-time PCR (qRT-PCR), which has become the gold standard for relative gene expression analysis and one of the major validation methods after high throughput discovery. Then, a logistic regression model was built to normalize the miRNA expression data from miRNA array, by utilizing the results from qRT-PCR and some auxiliary variables. Twenty additional miRNAs were selected to validate the predicted results by the novel model. The result shows that the consistency between the qRT-PCR and array results was significantly improved with the new normalization method. Compared to other popularly used normalization methods, the logistic regression model efficiently calibrates the variance across arrays and improves miRNA microarray discovery accuracy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1984.