Small-Cell Lung Cancer and Limbic Encephalitis
Authors: MAURIE MARKHAM
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 June 1982Small-Cell Lung Cancer and Limbic EncephalitisMAURIE MARKHAM, M.D., MARTIN D. ABELOFF, M.D.MAURIE MARKHAM, M.D., MARTIN D. ABELOFF, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-6-785_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Remote effects of cancer on the nervous system have been well described clinically but the pathophysiologic basis of such events is poorly understood (1-3). Similarly, little information is available on the response of these paraneoplastic syndromes to specific antitumor therapy. We describe a patient with limbic encephalitis secondary to small-cell carcinoma of the lung whose neurologic manifestations reversed dramatically after treatment.A 45-year-old woman with no history of neurologic dysfunction had the sudden onset of temporal lobe seizures characterized by uncontrolled grimacing, vocalization, disorientation, and bilateral hyperextension of her arms and legs. An electroencephalogram (EEG) showed a...References1. BRAINNORRIS WF, eds. The Remote Effect of Cancer on the Nervous System. New York: Grune & Stratton; 1965. Google Scholar2. CORSELLISGOLDBERGNORTON JGA. "Limbic encephalitis" and its association with carcinoma. Brain. 1968;91:481-96. CrossrefMedlineGoogle Scholar3. GRECOHAINSWORTHSISMANIRICHARDSONHANDEOLDHAM FJARKR. Hormone production and paraneoplastic syndromes. In: GRECO FA, OLDHAM RK, BUNN PA, eds. Small Cell Lung Cancer. New York: Grune & Stratton; 1981. Google Scholar4. LIVINGSTON R. Small cell carcinoma of the lung. Blood. 1980;56:575-84. CrossrefMedlineGoogle Scholar5. PAONEJEYASINGHAM JK. Remission of cerebellar dysfunction after pneumonectomy for bronchogenic carcinoma. N Engl J Med. 1980;302:156. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Johns Hopkins Oncology Center Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAutoimmune limbic encephalitisLIMBIC ENCEPHALITIS AS A PARENEOPLASTIC MANIFESTATION OF RENAL CELL CARCINOMALIMBIC ENCEPHALITIS AS A PARENEOPLASTIC MANIFESTATION OF RENAL CELL CARCINOMANonconvulsive status epilepticus in patients with cancerParaneoplasia and Autoimmunologic Injury of the Nervous System: The Anti-Hu SyndromeParaneoplastic effects of pulmonary endocrine neoplasmsParaneoplastic limbic encephalitis: clinico-pathological correlations.Paraneoplastic limbic encephalitis: Neuropsychiatric presentationLimbic encephalitisParaneoplastic SyndromesParaneoplastic limbic encephalopathy with testicular carcinoma: A reversible neurologic syndromeNeurological Paraneoplastic SyndromesParaneoplastic limbic encephalopathyBehavioral manifestations of paraneoplastic encephalopathyCase 30-1985: Limbic EncephalitisLimbic encephalopathy as a nonmetastatic complication of oat cell lung cancer 1 June 1982Volume 96, Issue 6_Part_1Page: 785-785KeywordsElectroencephalographyEncephalitisEpileptic seizuresLung and intrathoracic tumorsNervous systemRespiratory system proceduresTemporal lobe Issue Published: 1 June 1982 PDF DownloadLoading ...