tbuckley/cabot-search huggingface dataset:
Isotope Bioassay for "Thrombopoietin"
Authors: D. G. Penington
Journal: BMJ (1970)

An assay system has been developed in mice for the humoral agent "thrombopoietin." This is based on utilization in newly-formed platelets of the radio-amino-acid (75)Se selenomethionine 24 hours after intravenous injection. The possibility that the results could be due to the effects of species antibody, to foreign protein, or to an effect primarily on selenomethionine metabolism, has been explored, but the findings are consistent with the presence of a physiological humoral factor. Thrombopoietin has been shown to be present in the plasma of patients suffering from severe thrombocytopenia of varied aetiology.
Massachusetts Medical Society
Authors: Statler Hilton
Journal: New England Journal of Medicine (1963)

SECTION LUNCHEONS12:00 m.—2:00 p.m.Anesthesiology, Parlor C Factors Affecting the Spread and Intensity of Peridural Anesthesia Oral B. Crawford, M.D., Clinical Associate Professor, University of Missouri School of Medicine; Chairman, Department of Anesthesia, St. John's Hospital, Springfield, Missouri.Physical Medicine, Parlor D Physical Treatment of the Orthopedic Patient Hans Kraus, M.D., Associate Professor, Physical Medicine and Rehabilitation, New York University College of Medicine.Internal Medicine, Parlor A Hypertension Robert W. Wilkins, M.D., Professor and Chairman of Medicine, Boston University School of Medicine; Director, Robert Dawson Evans Memorial Department of Clinical Research, Massachusetts Memorial Hospitals.Radiology, Parlor B A Quarter . . .
ELECTRON MICROSCOPY OF THE SKIN IN ERYTHROPOIETIC PROTOPORPHYRIA
Authors: ELIZABETH A. RYAN, G. T. MADILL
Journal: British Journal of Dermatology (1968)

SUMMARY. —An electron microscopical examination has been made of skin from 4 patients with erythropoietic protoporphyria. Both exposed areas and skin usually covered by clothing were studied. In exposed skin from the knuckle and dorsum of the hand the main abnormality is associated with small blood vessels in the upper part of the dermis. The amorphous material seen on light microscopy is found to consist of a multilayered partially fragmented basement membrane, and finely fibrillar material of moderate electron density which permeates and surrounds the vessel walls. The presence of this substance in the vessel walls and its abrupt junction with the normal dermal connective tissue supports the idea that it is derived from constituents of the blood or from the vessels themselves rather than by degeneration of dermal connective tissue. Nothing abnormal is seen in covered skin from the back.
Update in Rheumatology
Authors: David B. Hellmann
Journal: Annals of Internal Medicine (2004)

Updates16 November 2004Update in RheumatologyDavid B. Hellmann, MDDavid B. Hellmann, MDFrom Johns Hopkins University School of Medicine, Baltimore, Maryland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-10-200411160-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This year's Update in Rheumatology incorporates articles on a range of topics, including vasculitis, rheumatoid arthritis, the antiphospholipid antibody syndrome, systemic lupus erythematosus, and osteoarthritis.VasculitisLarge-Artery Disease Was Common in Patients with Giant-Cell Arteritis Nuenninghoff DM, Hunder GG, Christianson TJ, et al. Incidence and predictors of large-artery complication (aortic aneurysm, aortic dissection, and/or large-artery stenosis) in patients with giant cell arteritis: a population-based study over 50 years. Arthritis Rheum. 2003;48:3522-31. [PMID: 14674004]Giant-cell arteritis is among the most common forms of systemic vasculitis in adults; the incidence is 1 in 5000 among people older than 50 years of age. Giant-cell ...References1. Urowitz MB, Bookman AA, Koehler BE, Gordon DA, Smythe HA, Ogryzlo MA. The bimodal mortality pattern of systemic lupus erythematosus. Am J Med. 1976;60:221-5. [PMID: 1251849] CrossrefMedlineGoogle Scholar2. Asanuma Y, Oeser A, Shintani AK, Turner E, Olsen N, Fazio S, et al. Premature coronary-artery atherosclerosis in systemic lupus erythematosus. N Engl J Med. 2003;349:2407-15. [PMID: 14681506] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: David B. Hellmann, MDAffiliations: From Johns Hopkins University School of Medicine, Baltimore, Maryland.Disclosures: None disclosed.Corresponding Author: David B. Hellmann, MD, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, B-110, 4940 Eastern Avenue, Baltimore, MD, 21224; e-mail, [email protected]edu.Contributing Editor: Jennifer Fisher Wilson. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVaskuläre Notfälle in der Dermatologie 16 November 2004Volume 141, Issue 10Page: 801-804KeywordsAneurysmsAtherosclerosisCyclophosphamideKneesLupus erythematosusOsteoarthritisRheumatoid arthritisStenosisT cellsVasculitis ePublished: 16 November 2004 Issue Published: 16 November 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Identification of Authentic Estrogen Receptor in Cultured Endothelial Cells
Authors: Christo D. Venkov, Alan B. Rankin, Douglas E. Vaughan
Journal: Circulation (1996)

Background Estrogen plays a major role in the delayed expression of coronary heart disease (CHD) in women, and recent data indicate that postmenopausal estrogen therapy reduces the incidence of CHD by &gt;40%. The mechanism or mechanisms through which estrogen exerts this benefit are unknown, although effects on blood pressure, carbohydrate and lipid metabolism, and coagulation have been suggested. We hypothesized that at least part of the effect of estrogen in reducing the incidence of CHD is due to an effect on endothelial cell function. Methods and Results In the present study, we examined human aortic and umbilical vein endothelial cells and bovine aortic endothelial cells for the presence of estrogen receptors (ERs) through immunoblot and mRNA analyses. Electrophoretic mobility shift assays were also performed to determine the DNA-binding properties of the putative ERs. Nuclear extracts from all three endothelial cell types were found to contain a 67-kD protein that reacted with anti-ER monoclonal antibodies specific to different domains of the ERs. Each of these types of cells expresses proteins that bind specifically to consensus estrogen-responsive elements. Finally, Northern blots verified that endothelial cells express abundant amount of mRNA for the ER. Conclusions These data indicate that endothelial cells constitutively possess the potential for transcriptional regulation of target genes by estrogen. The evolutionary conservation of this receptor in bovine and human endothelial cells suggests a common mechanism for estrogen regulation of endothelial function.
The streaming liver: A slow, divided flow?
Authors: R. J. Scothorne, R. N. M. Macsween
Journal: Hepatology (1986)

Twenty male adult rats weighing 200 g were injected with tritiated thymidine (3HTdR). The animals were then killed in groups of five, at the following times: 1 h, 1, 3 and 5 weeks. Autoradi-ograms of sections through the liver were prepared. The distances between labelled cells and the portal space rim were measured. One hour after labelling most labelled cells were confined to a region extending from the portal space rim up to a distance of 700 μm, which roughy corresponds to Rappaport's hepatic acinus zones-1 and -2. Throughout the experiment lasting 5 weeks labelled cells entered zone-3 and advanced toward the terminal hepatic vein. Hepatocytes travelled at a daily velocity of 1.44 μm, covering daily 0.324% of the acinus diameter. During the experiment acinus size did not change appreciably. The estimated mean hepatocyte cell cycle time was 37 days and its life expectation, 201 days. These experiments show that the liver is essentially a slowly renewing cell population. Hepatocytes nascent at the portal space gradually stream toward the terminal hepatic vein where they are probably eliminated by apoptosis. Their journey lasts 201 days. Since hepatocytes are glued together with tight junctions, all have to advance toward their terminal hepatic veins en masse. During their voyage, they traverse the three acinus zones, and since in each they produce different enzymes, each zone represents a differentiation state of the advancing cell. It is suggested further that the streaming hepatocyte carries with it its nerve supply and is accompanied by sinusoidal endothelium and Kupffer cells.
Long-term Follow-up of Endothelial Cell Change after Artisan Phakic Intraocular Lens Implantation
Authors: Ruchi Saxena, Sharmila S. Boekhoorn, Paul G.H. Mulder, Bastiaantje Noordzij, Gabriel van Rij, Gre P.M. Luyten
Journal: Ophthalmology (2007)
Liposomal Recombinant Human Superoxide Dismutase for the Treatment of Peyronie's Disease: A Randomized Placebo-Controlled Double-Blind Prospective Clinical Study
Authors: Claus R. Riedl, Peter Sternig, Günter Gallé, Florian Langmann, Brigitta Vcelar, Karola Vorauer, Andreas Wagner, Hermann Katinger, Heinz Pflüger
Journal: European Urology (2005)
MRI in predicting curative resection of rectal cancer: Defining a “window of opportunity” for laparoscopic surgery
Authors: Bruce F Sizer, Tan Arulampalam, Ralph Austin, Nicola Lacey, Don Menzies, Roger Motson
Journal: BMJ (2006)

EDITOR—The MERCURY Study Group provides clear evidence that preoperative magnetic resonance imaging can accurately predict surgical resection margins,1 and its work in particular, has already led to a paradigm shift in the preoperative investigation and treatment of rectal cancer, at least in the United Kingdom.

This is at least implicitly acknowledged in that both previous letters focus on magnetic resonance imaging in …
Diabetic Renal-Retinal Syndrome
Authors: Seymour R. Levin
Journal: JAMA (1981)

The care of the diabetic patient who is losing vision and renal function is a challenging and frustrating experience for the physician. Unfortunately, both crises often accompany one another. Their impact in the natural history of diabetes has overwhelming consequences for the patient and family.<i>Diabetic Renal-Retinal Syndrome</i>is a compilation of much basic and clinical information about the visual and renal disease associated with diabetes, from the proceedings of a conference held Nov 12 to 13, 1979, in Brooklyn, NY. The 36 chapters range from a few pages to more than 20 pages. Authors include ophthalmologists, nephrologists, surgeons, and a diabetologist. Work presented includes reviews of established information and clinical approaches, seedling studies, and speculations. The general areas covered are the problem of diabetes and its epidemiology and natural history, the pathology of the renal and retinal lesions, treatment modalities, and transplantation of kidney and pancreas. The book's strengths
Tuberculosis outbreak in East Greenland: groups at risk in an isolated arctic setting
Authors: Karen Bjorn-Mortensen, Aase B. Andersen, Anders Koch, Karin Ladefoged, Troels Lillebaek, Sascha W. Michelsen, Thomas Rendal, Mikael Andersson, Jacob Simonsen, Bolette Soborg
Journal: European Respiratory Journal (2015)

In 2009, an unusually high number of tuberculosis (TB) cases were reported from a settlement (Settlement X) in East Greenland. 4 years earlier, screening among schoolchildren had documented all children in this settlement to be free of Mycobacterium tuberculosis infection (MTI), whereas similar screenings had shown an MTI prevalence of 8% among schoolchildren in the rest of East Greenland [1]. The average TB incidence rate in East Greenland 5 years prior to the outbreak was ∼300 per 100 000 populations (fig. 1) [2, 3]. Teenagers from a previously M. tuberculosis transmission-free settlement were at particular risk during a TB outbreak <http://ow.ly/KALqZ> The authors thank the East Greenlandic population for participation in the study, and H.C.F. Sørensen (Tasiilaq, Greenland), and former TB nurses J. Sommer and M. Weismann (Tasiilaq, Greenland) for identifying and treating TB patients, and collecting and providing data. The authors also thank the healthcare personnel in East Greenland, the Chief Medical Officer, Queen Ingrid's Health Center (Nuuk, Greenland), Queen Ingrid's Hospital and the Central Laboratory (Nuuk, Greenland) for support and access to data.
Letter: Gonorrhoea in obstetrics and gynaecology.
Authors: F M Lanigan-O'Keefe
Journal: BMJ (1974)

would like to add one more consideration.I have recently observed two cases of post- anaesthetic jaundice in which halothane was employed.On careful investigation these were proved to be due to Gilbert's disease (congenital hyperbilirubinaemia). Starvation precipitates icterus in these cases, causing a raised plasma unconjugated bilirubin level, usually within 48 hours.The incidence of Gilbert's disease may be as high as 5% and it should therefore be a consideration in the differential diagnosis of cases of post- anaesthetic jaundice.-Iam, etc.,
Cross-Country Skiing
Authors: Stephen A. Roos
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Nordic skiing is an enjoyable sport, but as it becomes more popular, people who are less experienced and in poorer physical condition will be involved with an expected increase in physical injury and death. The report by Lyons and Porter (239:334, 1978) dealt with a variety of injuries that were the result of falls while skiing. Perhaps as important are the serious problems of hypothermia, frostbite, and avalanche. Nordic skiers are generally not well enough aware of potential avalanche hazards, and with long enough exposure, even the most experienced skier can have some close calls. Unlike the avalanche victim at a populated ski resort, the Nordic skier who is buried must rely on his companions to find him in time. Frostbite and hypothermia can affect even experienced skiers. Two physician friends of mine, both experienced mountaineers and skiers, were caught in a whiteout while on a day
Production of a chronic arthritis with ovalbumin. Its retention in the rabbit knee joint.
Authors: R Consden, A Doble, L E Glynn, A P Nind
Journal: Annals of the Rheumatic Diseases (1971)

OBJECTIVE: To determine in patients with systemic lupus erythematosus (SLE) (1) the frequency of antiprolactin (anti-PRL) autoantibodies, and (2) the relationships among anti-PRL autoantibodies, serum prolactin (PRL) levels, and lupus activity. METHODS: In a cross sectional study 259 consecutive patients with SLE were tested for serum PRL levels and anti-PRL autoantibodies based on disease activity. RESULTS: The frequency of anti-PRL was 5% (13/259), and all SLE patients with anti-PRL had hyperprolactinemia. There was lupus activity in 110 patients (42.5%) and there was no significant difference in frequency of anti-PRL autoantibodies between patients with or without lupus activity (5.5 vs 4.7%; p = 0.99). Only a high level of serum PRL was associated with lupus activity independent from other studied variables (p = 0.024). There was a negative but nonsignificant correlation between the titers of anti-PRL autoantibody and SLEDAI (r(s) = -0.16, p = 0.59). Anti-PRL positive patients had higher levels of serum PRL than anti-PRL negative patients (33.2+/-13.8 vs 11.6+/-13.2 ng/ml; p = 0.0001) and a significantly different frequency of hyperprolactinemia (100 vs 11.4%; p = 0.00001). CONCLUSION: The presence of anti-PRL autoantibodies was associated with hyperprolactinemic status and high serum PRL levels; these data suggest that anti-PRL autoantibodies could be the cause of hyperprolactinemia in a subset of patients with SLE. An increase in serum PRL levels proved to be an important independent factor related to lupus activity, but there was no relationship between anti-PRL autoantibodies and lupus activity.
Snake Poisoning—A Case of Plagiarism
Authors: Prentiss Willson
Journal: JAMA (1910)

To the Editor:—  My attention has just been called to an article entitled Practical Consideration of  Poisoning, by Benjamin H. Orndorff, B.A., M.D., Instructor in Pathology, Chicago College of Medicine and Surgery, Pathologist to Frances Willard Hospital, Chicago. This article was published in the Medical Standard , Chicago, September and December, 1909, pages 476 to 481 and 637 to 640. There was published by me in the Archives of Internal Medicine , Chicago, volume 1, June, 1908, pages 516 to 570, a paper entitled Snake Poisoning in the United States; a Study Based on an Analysis of 740 Cases. This paper was the result of a large amount of work, which involved not only an examination of the literature but a collection, by correspondence with physicians practicing in the South, of a considerable number of unpublished cases. This article was commented on editorially byThe Journal, July 11, 1908, page 132
827 PROGNOSTICATING VALUE OF ALTERED SERUM-SOLUBLE CD40L LEVELS AND CD40 EXPRESSION ON MONOCYTES IN FULMINANT HEPATIC FAILURE
Authors: Y.B. Zheng, S.B. Xie, D.Y. Xie, Y.F. Zhang, X.H. Zhang, B.L. Lin, Z.X. Zhao, Y.T. Chong, Z.L. Gao
Journal: Journal of Hepatology (2010)
Access to undergraduate medical education is being broadened
Authors: M A Lumsden
Journal: BMJ (2001)

EDITOR—Sheffield is not alone in making plans for the development of schemes to widen access to higher education as discussed by Angel and Johnson.1 The City of Glasgow incorporates as much as 60% of the areas of greatest deprivation in the United Kingdom. The number of school leavers from the west of Scotland who enter higher education is about half the national average (28.3% compared with 48% for higher education and 16% compared with 29.5% for university admission) and in extreme cases participation rates in higher education are as low as 4%. …
Immunologic response to different determinants of benzylpenicillin, amoxicillin, and ampicillin. Comparison between urticaria and anaphylactic shock
Authors: M.J. Torres, C. Mayorga, R. Pamies, C. Juarez, M. Blanca, A. Romano
Journal: Allergy (1999)

Background: Subjects with IgE‐mediated allergic reactions to penicillins can develop urticaria or anaphylactic shock. Urticaria is mainly associated with positivity to the major determinant of benzylpenicillin (BPO), and anaphylactic shock with minor determinants (MDM). The presence of IgG antibodies to BPO is thought to be mainly associated with urticaria, possibly protecting from anaphylactic shock. We aimed to study the skin test response to BPO and MDM, amoxicillin (AX), and ampicillin (AMP) in a group of subjects allergic to penicillins, and to evaluate the role of specific IgG. Methods: We studied a group of patients with immediate allergic reactions to penicillins, comparing urticaria and anaphylactic shock. Skin tests were done with BPO, MDM, AX, and AMP. Specific IgE and IgG antibodies to benzylpenicilloyl‐poly‐ l ‐lysine (BPO‐PLL) and amoxicilloyl‐poly‐ l ‐lysine (AXO‐PLL) were determined by RAST and ELISA, respectively. Results: Fifty‐nine patients were studied (30 with anaphylactic shock and 29 with urticaria). Skin test positivity to BPO was associated with urticaria ( P &lt;0.001), and positivity to MDM, AX, and AMP with anaphylactic shock ( P =0.006, P &lt;0.001, and P =0.002, respectively). Specific anti‐BPO‐PLL and AXO‐PLL IgG values were higher in patients than controls ( P &lt;0.001), but no differences were observed between urticaria and anaphylactic shock. Conclusions: Positivity to minor determinants of penicillins is associated more with anaphylactic shock than urticaria, but the role of IgG antibodies in helping to prevent the development of anaphylactic shock could not be confirmed. Abbreviations : BPO: benzylpenicilloyl; MDM: minor determinant mixture; AX: amoxicillin; AMP: ampicillin; AXO‐PLL: amoxicilloyl‐poly‐ l ‐lysine; BPO‐PLL: benzylpenicilloyl‐poly‐ l ‐lysine.
SYSTEMIC CONDITIONS IN RELATION TO ORAL SYMPTOMS AND SEPSIS
Authors: V. A. LATHAM
Journal: JAMA (1910)

Until recently this subject had not attracted the attention of medical or even dental writers to any extent, being only now and then touched on in connection with other matters. Lacking the aid of authority I shall try to show its importance in daily practice and, at the same time, ask our members to look more attentively into their cases and see if the work of one of us is not worthy of more concentrated effort on our part earnestly to trace the subject better. I refer to the teachings and papers of the secretary of the Section, Dr. E. S. Talbot, than whom no one has done more to bring together this joint work of the stomatologist and physician in systemic treatment for oral conditions. Who have better opportunities for observing the detrimental effect of a brain-cramming system of education at the expense of the bony and muscular systems
A role for the apoptosis inhibitory factor AIM/Spα/Api6 in atherosclerosis development
Authors: Satoko Arai, John M. Shelton, Mingyi Chen, Michelle N. Bradley, Antonio Castrillo, Angie L. Bookout, Puiying A. Mak, Peter A. Edwards, David J. Mangelsdorf, Peter Tontonoz, Toru Miyazaki
Journal: Cell Metabolism (2005)
Potent anti-angiogenesis and anti-tumor activity of a novel human anti-VEGF antibody, MIL60
Authors: Jing Yang, Qun Wang, Chunxia Qiao, Zhou Lin, Xinying Li, Yifei Huang, Tingting Zhou, Yan Li, Beifen Shen, Ming Lv, Jiannan Feng
Journal: Cellular and Molecular Immunology (2014)