tbuckley/cabot-search huggingface dataset:
CHRONIC PARONYCHIA..
Authors: R. H. MARTEN
Journal: British Journal of Dermatology (1959)

Journal Article CHRONIC PARONYCHIA.: A Mycological and Bacteriological Study. Get access R. H. MARTEN R. H. MARTEN Skill Department, King's College Hospital London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 71, Issue 12, 1 December 1959, Pages 422–426, https://doi.org/10.1111/j.1365-2133.1959.tb13378.x Published: 01 December 1959
238 AN ESTROGEN RECEPTOR ß SELECTIVE AGONIST EXERTS SPECIFIC PRO-APOPTOTIC EFFECTS AND PROMOTES TUMOR REGRESSION IN A RAT MODEL OF INTRA-HEPATIC CHOLANGIOCARCINOMA
Authors: M. Marzioni, A. Torrice, C. Rychlicki, L. Agostinelli, I. Pierantonelli, P. Rhönnstad, L. Trozzi, S. Saccomanno, T. Apelqvist, R. Gentile, C. Candelaresi, G. Fava, A. Benedetti, E. Gaudio, S. De Minicis, E. Kallin, D. Alvaro, S. Nilsson
Journal: Journal of Hepatology (2011)
Reduction in polypharmacy for epilepsy.
Authors: S D Shorvon, E H Reynolds
Journal: BMJ (1979)

A two-year prospective study of 40 adult outpatients with chronic epilepsy was carried out in which blood drug concentrations were monitored, and anticonvulsant polypharmacy was reduced to treatment with a single drug in 29 patients (72%). In the year after the reduction of treatment the control of seizures was improved in 16 patients (55%), unchanged in eight(28%), and worse in five (17%). Mental function was improved in 16 (55%). The main reason for failure to reduce to or maintain treatment with a single drug was exacerbation of seizures during the difficult withdrawal period, especially in patients with frequent seizures, taking several drugs, or with additional neuropsychological handicaps. It is more difficult to reduce polypharmacy than to avoid it in the first place. Polypharmacy may sometimes aggravate control of seizures.
The DNA-binding factor Ctcf critically controls gene expression in macrophages
Authors: Tatjana Nikolic, Dowty Movita, Margaretha EH Lambers, Claudia Ribeiro de Almeida, Paula Biesta, Kim Kreefft, Marjolein JW de Bruijn, Ingrid Bergen, Niels Galjart, Andre Boonstra, Rudi Hendriks
Journal: Cellular and Molecular Immunology (2013)
End-of-Life Care
Authors: Bruce C. Vladeck
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion
Authors: Qingli Shen, Vito R Cicinnati, Xiaoyong Zhang, Speranta Iacob, Frank Weber, Georgios C Sotiropoulos, Arnold Radtke, Mengji Lu, Andreas Paul, Guido Gerken, Susanne Beckebaum
Journal: Molecular Cancer (2010)

Abstract Background Micro-ribonucleic acid (miRNA)-199a-5p has been reported to be decreased in hepatocellular carcinoma (HCC) compared to normal tissue. Discoidin domain receptor-1 (DDR1) tyrosine kinase, involved in cell invasion-related signaling pathway, was predicted to be a potential target of miR-199a-5p by the use of miRNA target prediction algorithms. The aim of this study was to investigate the role of miR-199a-5p and DDR1 in HCC invasion. Methods Mature miR-199a-5p and DDR1 expression were evaluated in tumor and adjacent non-tumor liver tissues from 23 patients with HCC undergoing liver resection and five hepatoma cell lines by the use of real-time quantitative RT-PCR (qRT-PCR) analysis. The effect of aberrant miR-199a-5p expression on cell invasion was assessed in vitro using HepG2 and SNU-182 hepatoma cell lines. Luciferase reporter assay was employed to validate DDR1 as a putative miR-199a-5p target gene. Regulation of DDR1 expression by miR-199a-5p was assessed by the use qRT-PCR and western blotting analysis. Results A significant down-regulation of miR-199a-5p was observed in 65.2% of HCC tissues and in four of five cell lines. In contrast, DDR1 expression was significantly increased in 52.2% of HCC samples and in two of five cell lines. Increased DDR1 expression in HCC was associated with advanced tumor stage. DDR1 was shown to be a direct target of miR-199a-5p by luciferase reporter assay. Transfection of miR-199a-5p inhibited invasion of HepG2 but not SNU-182 hepatoma cells. Conclusions Decreased expression of miR-199a-5p contributes to increased cell invasion by functional deregulation of DDR1 activity in HCC. However, the effect of miR-199a-5p on DDR1 varies among individuals and hepatoma cell lines. These findings may have significant translational relevance for development of new targeted therapies as well as prognostic prediction for patients with HCC.
THE PATHOGENESIS OF XANTHOMATOSIS, WITH REPORT OF A CASE
Authors: G. A. HARRISON, A. WHITFIELD
Journal: British Journal of Dermatology (1923)

Journal Article THE PATHOGENESIS OF XANTHOMATOSIS, WITH REPORT OF A CASE Get access G. A. HARRISON, B.A., M.B., B. Ch.Cantab, G. A. HARRISON, B.A., M.B., B. Ch.Cantab Biochemist, King's College Hospital, London Search for other works by this author on: Oxford Academic Google Scholar A. WHITFIELD, M.D.Lond., F.R.C.P. A. WHITFIELD, M.D.Lond., F.R.C.P. Professor of Dermatology, King's College; and Physician‐in‐Charge, Skin Department, King's College Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 35, Issue 3, 1 March 1923, Pages 81–92, https://doi.org/10.1111/j.1365-2133.1923.tb09089.x Published: 01 March 1923
Antibiotic use in general practice.
Authors: J B Metcalfe
Journal: BMJ (1976)

and presumably by different people.The study we have referred to, carried out by one investigator, avoided this criticism by using paired data from the same patients and this may explain the contrasting results.Also it is possible that sampling the skin immediately after shaving gives rise to the very high counts which were noted in the data we present owing to the exposure of viable organisms from the deep layers of the skin.Certainly our evidence would not support a policy ofshaving the operation site immediately before surgery, and more evidence is needed before this becomes widely adopted.Perhaps the answer lies in abandoning the practice of preoperative shaving and using depilatory creams.The results of Mr Powis and his col- leagues and of previous work5 certainly support this suggestion.
Abstract 3105: Orphan nuclear receptor NR4A2 exhibits oncogenic activity in lung cancer cells.
Authors: Chunxia Cao, Min Zhang, Ruli Gao, Douglas Cress, Zirong Chen, Lizi Wu, Maria Zajac Kaye, Frederic Kaye
Journal: Cancer Research (2013)

Abstract LKB1 (also known as STK11) is a frequent target for mutations in lung cancer, however, the role of LKB1 loss in tumorigenesis is undefined. NR4A2, together with NR4A1, and NR4A3, constitute the nuclear receptor (NR) subfamily 4A (NR4A), which are orphan NRs lacking identified ligands. NR4A family has been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis. However, there are conflicting data for tumorigenesis as NR4A1 and NR4A3 act as tumor suppressors in leukemia mouse models, while NR4A2 appears to stimulate tumor cell growth in vitro. Our laboratory discovered that the CRTC1 gene was aberrantly activated in LKB1-null cancer cells, stimulating the transcription of cAMP/CREB targets including NR4A gene members. The aim of this study is to examine NR4A2 as a potential oncogene and therapeutic target under the regulation of CRTC1 in LKB1 wildtype and null lung cancer cells. We demonstrated here that somatic loss of LKB1 in tumor cells was associated with underphosphorylation and nuclear localization of CRTC1, this resulted in upregulated expression and stronger transcriptional activity of NR4A2 in LKB1 mutant lung cancer cells and clinical primary lung cancer samples. We confirmed that forskolin, which can activate adenylate cyclase then catalyze the transformation of ATP to cAMP, could induce CRTC1 dephosphorylation resulting in enhanced NR4A2 expression. We identified that activation of the CRTC gene family induced NR4A2 expression, whereas knockdown of CRTCs decreased the expression of NR4A2. Furthermore, short hairpin RNA-mediated down-regulation of NR4A2, results in attenuated lung cancer cell proliferation and colony formation in vitro and decreased the tumor sizes in vivo in nude mice. In summary, our data suggested a CRTC-mediated transcriptional regulatory mechanism for NR4A2 activity, and proposed an oncogenic role of NR4A2 in LKB1 null lung cancer cell lines. Citation Format: Chunxia Cao, Min Zhang, Ruli Gao, Douglas Cress, Zirong Chen, Lizi Wu, Maria Zajac Kaye, Frederic Kaye. Orphan nuclear receptor NR4A2 exhibits oncogenic activity in lung cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3105. doi:10.1158/1538-7445.AM2013-3105
P107Role of plasma membrane-associated AKAPs 15/18 and 79 for the regulation of cardiac IK1 current by protein kinase A
Authors: C Seyler, D Scherer, C Koepple, M Kulzer, S Korkmaz, D Thomas, Z Kaya, J Backs, HA Katus, E Zitron
Journal: Cardiovascular Research (2014)

Background: The cardiac inwardly rectifying potassium current IK1 stabilises the diastolic resting membrane potential of ventricular cardiomyocytes. Protein kinase A (PKA) induces an inhibition of IK1 current which strongly promotes focal arrhythmogenesis under increased catecholamine levels. The molecular mechanisms underlying this regulation have only partially been elucidated to date. Furthermore, the role of A Kinase Anchoring Proteins (AKAPs) in this regulation has not been examined yet. The objective of this project was to elucidate the molecular mechanisms underlying the inhibition of IK1 by PKA and to identify novel molecular targets for antiarrhythmic therapy downstream β-adrenoreceptors.
Acute obstructive cholangitis caused by barium refluxed into the common bile duct through endoprosthesis
Authors: T. Yoshino, S. Yazumi, T. Chiba
Journal: Endoscopy (2007)

A 65-year-old man was hospitalized because of early gastric cancer (UICC, stage II) and pancreatic cancer (UICC, Stage III). An endoprosthesis, 7 Fr in size, had been placed for obstructive jaundice due to pancreatic cancer in another hospital. Laboratory data on admission showed slight elevation of total bilirubin (1.7 mg/dL). High-grade fever and remarkable jaundice developed (total bilirubin, 6.1 mg/dL) 6 days after an upper gastrointestinal series for evaluation of gastric cancer. We considered acute obstructive cholangitis due to occlusion of the endoprosthesis, and performed endoscopic retrograde cholangiopancreatography.
CHANGES IN THE VOLUME OF PLASMA AND ABSOLUTE AMOUNT OF PLASMA PROTEINS IN NEPHRITIS
Authors: G. C. Linder, C. Lundsgaard, D. D. Van Slyke, E. Stillman
Journal: The Journal of Experimental Medicine (1924)

1. We have not observed gross increases in plasma volume in glomerulonephritis, nephrosis, or nephrosclerosis, even when the concentration of plasma proteins was much below normal. Our results indicate the probability that "hydremic plethora" does not occur. 2. The low protein concentration frequently observed in the plasma in nephritis is not due to increased plasma volume but to a decrease of the total amount of plasma protein in the body. 3. Changes in plasma volume showed no constant relationship to changes in edema.
Anesthesia for Infants and Children
Authors: Leonard Bachman
Journal: JAMA (1964)

The first edition of Dr. Smith's book in 1959 provided a long-needed service in bringing together ideas and practices in pediatric anesthesia. For 14 years he had been carefully evolving a discipline for the management of his many anesthesia problems at Boston Children's Hospital. In 1959 Dr. Smith's conservative approach to many of his problems might have been acceptable, since he represented an authoritative group. It is disappointing that in 1963, in the second edition of his book, he has changed little. What seemed conservative in 1959 might be construed as old-fashioned in 1964. For example, there is little enthusiasm for advanced monitoring, very little information on hypothermia in encephalitis and head injuries. He continues to advocate the use of ether for neurosurgical operations and has a timid approach to controlled respirations—especially in neonatal operations. The many illustrations of open-drop techniques and the antiquated suggestions for anesthesia for pyloric stenosis
MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer
Authors: Wei Shi, Kate Gerster, Nehad M. Alajez, Jasmine Tsang, Levi Waldron, Melania Pintilie, Angela B. Hui, Jenna Sykes, Christine P'ng, Naomi Miller, David McCready, Anthony Fyles, Fei-Fei Liu
Journal: Cancer Research (2011)

Several microRNAs have been implicated in human breast cancer but none to date have been validated or utilized consistently in clinical management. MicroRNA-301 (miR-301) overexpression has been implicated as a negative prognostic indicator in lymph node negative (LNN) invasive ductal breast cancer, but its potential functional impact has not been determined. Here we report that in breast cancer cells, miR-301 attenuation decreased cell proliferation, clonogenicity, migration, invasion, tamoxifen resistance, tumor growth, and microvessel density, establishing an important oncogenic role for this gene. Algorithm-based and experimental strategies identified FOXF2, BBC3, PTEN, and COL2A1 as candidate miR-301 targets, all of which were verified as direct targets through luciferase reporter assays. We noted that miR-301 is located in an intron of the SKA2 gene which is responsible for kinetochore assembly, and both genes were found to be coexpressed in primary breast cancer samples. In summary, our findings define miR-301 as a crucial oncogene in human breast cancer that acts through multiple pathways and mechanisms to promote nodal or distant relapses.
Natural history and patterns of recovery of contractile function in single left ventricle after Fontan operation.
Authors: T Sluysmans, S P Sanders, M van der Velde, A Matitiau, I A Parness, P J Spevak, J E Mayer, S D Colan
Journal: Circulation (1992)

BACKGROUND Before the era of the Fontan procedure, the typical course of patients with single left ventricle (LV) consisted of heart failure and death during the second or third decade of life. Despite the advent of effective palliative therapy, ventricular dysfunction remains a significant clinical problem for these patients. METHODS AND RESULTS To investigate the causes of ventricular dysfunction in these patients and to determine whether Fontan-type repair reverses deterioration of LV function, the ventricular dimensions, volume, shape, wall stress, and systolic function were determined by echocardiography in 84 patients 0.2-35 years old with double-inlet single LV or tricuspid atresia. Measurements were obtained in 67 patients after palliation (arterial shunt or pulmonary artery band) and in 47 patients a median of 4.4 years after a Glenn (n = 9) or a Fontan operation (n = 38). Before a Fontan procedure, ventricular volumes were 2 to 3 times normal. Ventricular afterload, assessed as circumferential and meridional end-systolic wall stress, became abnormal after 2 years of age. With age, LV shape changed progressively from ellipsoidal to spherical, as indicated by the decrease in long axis:short axis ratio from normal (1.9) toward unity. Concomitantly, the ratio of circumferential to meridional end-systolic wall stress fell from 1.3 to unity, the ratio of a sphere at equilibrium. This age-related change in shape and load occurred in concert with progressive deterioration of LV systolic function and contractility. Aortic oxygen saturation, an indicator of pulmonary blood flow and therefore volume work in single-ventricle physiology, was inversely and independently correlated with contractility. In the group of patients in whom a Glenn or a Fontan operation was performed at &lt; 10 years of age, ventricular dimensions, volumes, and wall stress diminished and LV function and contractility improved after surgery (p &lt; 0.001). In patients undergoing surgery after 10 years of age, few had improvement of LV function after surgery. Postoperative ventricular function and contractility were inversely related to age at surgery and to aortic oxygen saturation measured before surgery. CONCLUSIONS Although Fontan-type repair of single ventricle early in life is associated with reversal of the abnormal contractile mechanics associated with age and volume load, this capacity for recovery diminishes with age at surgery.
Incidence and Significance of Candiduria
Authors: Philip K. Goldberg
Journal: JAMA (1979)

The 100,000 colony count has been used without careful evaluation for the diagnosis of renal candidiasis. Therefore, a prospective study was done on 1,004 urine samples from patients without signs of candidiasis to determine the incidence of candiduria and<i>Candida</i>colony counts. These were compared with colony counts from histologically proved cases of renal candidiasis. The incidence of candiduria varied from a low of 4% in men to a high of 39% in girls during their second week of antibiotic therapy. The overall mean colony count was 1,292±1,500. The mean colony count in clean-catch urine specimens from six proved cases of renal candidiasis was 23,750±12,311. The difference in colony counts from proved and unproved cases is statistically significant. Counts greater than 10,000<i>Candida</i>organisms per milliliter require further investigation. (<i>JAMA</i>241:582-584, 1979)
A suitable case
Authors: B Dixon
Journal: BMJ (1994)

One furtive glance on a Sunday morning and I've done with the “style” pages. The photographs are peculiar, the prices silly, much of the text baffling.

But then fashion itself is uncanny. Several years ago there was a trend in suits, double breasted ones supplanting the single breasted sort. Around that time I met someone for lunch and noticed that he had become double breasted. By chance we met twice more over the next fortnight and again he was wearing double breasted jackets. After a lifetime of single breasted suits, he had now purchased at least three new, different expensive suits with an additional swathe of material.

What had happened? Was it a matter of getting out …
Radiofrequency-Controlled Catheter Pacemaker
Authors: William W. L. Glenn, Seymour Furman, Alvin J. Gordon, Doris J. W. Escher, Daniel W. van Heeckeren
Journal: New England Journal of Medicine (1966)

THE transvenous endocardial electrode catheter1 and the radiofrequency induction assembly2 have been used for cardiac pacing with success over the past seven years. The catheter electrode has proved to be a satisfactory tool for short-term and long-term pacing and has been particularly useful for gaining immediate control of, and preserving, the heartbeat until installation of a more permanent unit.3 , 4 Of the difficulties encountered with its early application, only the transmission of infection via the exteriorized electrodes and perforation of the heart continue to be potentially serious. A recent report describes a method of long-term pacing with the pacemaker buried beneath . . .
Multiple Liver Amoebic Abscesses Detected on FDG PET/CT
Authors: Françoise Annie Cavailloles, Agnes Mure, Hicham Nasser, Anne-Lise Lecapitaine, Françoise Granier
Journal: Clinical Nuclear Medicine (2013)

We report a case of liver amoebic abscesses in a 58-year-old man referred for a FDG PET/CT with an initial diagnosis of secondary hepatic lesions. This patient, coming from Sri Lanka, presented with fever and shivers, pain in the right flank, vomiting, and diarrhea for a month. The FDG PET/CT showed a hepatic heterogeneous uptake with multiple cold lesions surrounded by a faint hypermetabolism. As this result was not typical of hepatic metastases, a hepatic biopsy was performed leading to the diagnosis of amoebic abscess.
What is an agent that it experiences P-consciousness? And what is P-consciousness that it moves an agent?
Authors: Roger N. Shepard
Journal: Behavioral and Brain Sciences (1995)

Abstract If phenomenal consciousness is distinct from the computationally based access-consciousness that controls overt behavior, how can I tell which things (other than myself) enjoy phenomenal consciousness? And if phenomenal consciousness 'plays no role in controlling overt behavior, how do human bodies come to write target articles arguing for the existence of phenomenal consciousness?
Need for improvement in dermatology services.
Authors: R Howell
Journal: BMJ (1977)

Dr Slater is wrong when he states that "Wright3 estimated that a 1°C rise in tempera- ture will increase the estimated blood alcohol concentration by 6.5o/o."Careful scrutiny of Wright's paper shows that he made no such claim.However, in the same proceedings Dubowski4 stated that "it may be well to point out that each 1°C increase in actual alveolar breath exit temperature between 34°C and 37°C would tend to increase a blood alcohol concentration calculated on the basis of an assumed 1:2100 ratio by about 6 50 over the actual level.
PNEUMONIA; THE NON-ALCOHOLIC TREATMENT.
Authors: THOS. P. SCULLY
Journal: JAMA (1896)

Contrary to all that has been written showing the pernicious effectf of alcohol on the system in health and disease, and contrary to the admonitions of some of the greatest lights of the medical profession, past and present (a few of whom I may mention, viz., Sir Astley Cooper, Prof. Willard Parker, Dr. Benjamin Ward Richardson, Dr. Wm. B. Carpenter, Dr. N. S. Davis and numerous others equally as well known), as to its deleterious effects in disease, and notwithstanding the fact that the mortality rate from pneumonia is higher than fifty years ago, still we persist in using alcohol in pneumonia crouposa. You can scarcely pick up a text-book or journal for reference as to the treatment of pneumonia, without being confronted with the fact that you must stimulate your patient with alcohol. We boast of the great advancements made in surgery and medicine, and contrast our knowledge of
A Dip in the Pool
Authors: Robert W. Marion
Journal: JAMA (1987)

Arriving at the hospital, I viewed the madhouse that was the pediatric ER with ambivalence: on the one hand, I was happy I'd be in clinic that morning; on the other, I knew that starting at 1 PM, I'd be in charge of this insanity and that my shift wouldn't end until 4 AM, when things had calmed down enough for the night float to have a better than even chance of surviving until the next morning. Spotting Phyllis, that very night float, I approached and asked, "How're you doing?" Looking frazzled, she stared at me. "I hate this place!" she said, as she sat down. "This is the first time I've sat down since 2 AM. The paramedics brought in a couple of sisters who got burned. The 2 year old was DOA and the 4 year old was in shock. We worked on her for an hour but