FAB M7: Acute Megakaryoblastic Leukemia—Beyond Morphology
Authors: CLARA D. BLOOMFIELD
Journal: Annals of Internal Medicine (1985)

Editorials1 September 1985FAB M7: Acute Megakaryoblastic Leukemia—Beyond MorphologyCLARA D. BLOOMFIELD, M.D., RICHARD D. BRUNNING, M.D.CLARA D. BLOOMFIELD, M.D., RICHARD D. BRUNNING, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-450 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe French-American-British (FAB) leukemia cooperative study group, in this issue (1), adds another category of acute nonlymphocytic leukemia to their classification: acute leukemia of megakaryocyte lineage, or M7. As with prior FAB categories, M7 defines a type of leukemia that has been recognized for many years (2). Recently, as a result of developments in ultrastructural cytochemistry and immunologic phenotyping, acute leukemias of megakaryocytic lineage have been diagnosed increasingly (3-13); at least one group has reported that this type accounts for more than 10% of acute nonlymphocytic leukemias (10). Although a distinct clinical syndrome has not been delineated, it has been...References1. BENNETTCATOVSKYDANIEL JDM. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7): a report of the French-American-British Cooperative Group. Ann Intern Med. 1985;103:460-2. LinkGoogle Scholar2. VON BOROSKARENYI JA. Über einen Fall von akuter Megakaryoblastenleukämie, zugleich einige Bemerkungen zum Problem der akuten Leukämie. Z Klin Med. 1931;118:697-718. Google Scholar3. FLANDRINDANIELVALENSISCHAISONBRETON-GORIUS GMFGJ. Leucémie aiguë à mégacaryoblastes: étude clinique et morphologique de 11 observations. Actual Hematol. 1977;11:200-12. Google Scholar4. 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Author, Article, and Disclosure InformationAffiliations: University of Minnesota Health Sciences Center Minneapolis, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPediatric Acute Myeloid Leukemia—Past, Present, and FutureEpigenetic and Genetic Alterations in LeukemiaClinical Utility of Next-Generation Sequencing in Acute Myeloid LeukemiaLymphoma and LeukaemiaAcute myeloid leukemiaHematopoietic stem cell transplantation for de novo acute megakaryocytic leukemia in first complete remission: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT)Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in childrenBiology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experienceCongenital Acute Megakaryoblastic Leukemia (M7) With Chromosomal t(l;22)(p13;q13) Translocation in a Set of Identical TwinsAcute Megakaryoblastic Leukemia: Importance of Bone Marrow Biopsy in DiagnosisAggressive polychemotherapy for acute myelofibrosisAcute Megakaryocytic Leukemia (M7) in ChildrenAcute Megakaryocytic LeukemiaCytochemistry and Immunocytochemistry in Bone Marrow Examination: Contemporary Techniques for the Diagnosis of Acute Leukemia and Myelodysplastic Syndromes: A Combined ApproachMonosomy 5 in acute megakaryoblastic leukemiaA prospective trial of the treatment of acute megakaryoblastic leukaemiaAcute megakaryocytic leukemia. Flow cytometric analysis of DNA content at diagnosis and during the course of therapyTreatment of Acute Megakaryocytic LeukemiaWILLIAM R. FRIEDENBERG, M.D., JOSEPH J. MAZZA, M.D., JOHN D. HINES, M.D.The Diagnosis of Megakaryoblastic LeukemiaLAURENCE CORASH, M.D., JAY H. BECKSTEAD, M.D. 1 September 1985Volume 103, Issue 3Page: 450-452KeywordsAcute myeloid leukemiaCytochemistryMegakaryocytesResearch funding ePublished: 1 December 2008 Issue Published: 1 September 1985 PDF downloadLoading ...