Nephropathy Associated with Penicillin and Homologues
Authors: ROBERT W. SCHRIER
Journal: Annals of Internal Medicine (1966)

Article1 January 1966Nephropathy Associated with Penicillin and HomologuesROBERT W. SCHRIER, M.D., ROGER J. BULGER, M.D., PAUL P. VANARSDEL JR., M.D., F.A.C.P.ROBERT W. SCHRIER, M.D.Search for more papers by this author, ROGER J. BULGER, M.D.Search for more papers by this author, PAUL P. VANARSDEL JR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-116 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPenicillin and its homologues are relatively nontoxic and even in high doses have no known renal toxicity in man (1, 2). By contrast, estimates of the frequency of allergic reactions have ranged from 1% to over 10% (3). In comparison to the more obvious and dramatic allergic reactions to penicillin, renal involvement has received little attention (4, 5). Acute anaphylaxis is obviously a major threat to life; but progressive renal damage may also be fatal, and its insidious development may not be recognized (6). However, only 22 cases of penicillin-related nephritis have appeared in the literature since Anderson (7) made...References1. SCHREINERMAHER GEJF: Toxic nephropathy. Amer. J. Med. 32: 409, 1965. CrossrefGoogle Scholar2. BARBERCHAIN MEB: Antibacterial chemotherapy. Ann. Rev. Pharmacol. 4: 115, 1964. CrossrefGoogle Scholar3. VANARSDEL PP: Allergic reactions to penicillin. JAMA 191: 238, 1965. CrossrefMedlineGoogle Scholar4. KIRBYBULGER WMRJ: The new penicillins and cephalosporins. Ann. Rev. Med. 15: 393, 1964. CrossrefMedlineGoogle Scholar5. HEWITT WL: The penicillins. JAMA 185: 264, 1964. CrossrefGoogle Scholar6. RICH AR: Tissue reactions produced by sensitivity to drugs, in Sensitivity Reactions to Drugs, edited by ROSENHEIM, M. L., MOULTON, R. Charles C Thomas, Springfield, Ill., 1958, pp. 196-207. Google Scholar7. 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J. 1: 210, 1950. MedlineGoogle Scholar20. GELL PG: Serum sickness. Ibid., p. 386. Google Scholar21. RICH AR: The pathology and pathogenesis of experimental anaphylactic glomerulonephritis in relation to human acute glomerulonephritis. Bull. Hopkins Hosp. 98: 120, 1956. MedlineGoogle Scholar22. RICHGREGORY ARJE: The experimental demonstration that periarteritis is a manifestation of hypersensitivity. Bull. Hopkins Hosp. 72: 65, 1943. Google Scholar23. VANARSDELO'ROURKEHORANKUMASAKA PPTKJDY: Serum hemagglutinating antibodies in penicillin allergy. JAMA 185: 584, 1963. CrossrefMedlineGoogle Scholar24. FEIGINFIASCONE RDA: Hematuria and proteinuria associated with methicillin administration. New Eng. J. Med. 272: 903, 1965. CrossrefMedlineGoogle Scholar25. GRATTON WA: Hematuria and azotemia associated with administration of methicillin. J. Pediat. 64: 287, 1964. MedlineGoogle Scholar26. LANYANTHOINEREBEIXVINIAKER PDGP: Nephropathies par intolerance à la methicilline. Ann. Med. Nancy 2: 1489, 1963. MedlineGoogle Scholar27. VANARSDELO'ROURKE PPTK: Serum antibodies to penicillin homologues in human penicillin allergy. Clin. Res. 11: 107, 1963. Google Scholar28. PARKERTHIEL CWJA: Studies in human penicillin allergy: a comparison of various penicilloyl-polylysines. J. Lab. Clin. Med. 62: 482, 1963. MedlineGoogle Scholar29. UNGERNEMUTH AMHI: Penicillinase treatment of acute renal insufficiency due to penicillin hypersensitivity. JAMA 167: 1237, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, Seattle, Wash.This study was supported in part by training grant 5 TI AI 11-07, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Paul P. VanArsdel, Jr., M.D., Department of Medicine, University of Washington, Seattle, Wash. 98105. 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KUNIN, M.D., F.A.C.P.Unusual Antimicrobial Toxic ReactionsHematuria associated with methicillin therapy 1 January 1966Volume 64, Issue 1Page: 116-127KeywordsAllergy and immunologyAnaphylaxisGlomerulonephritisMedical servicesNephritisPenicillinToxicityVasculitis Issue Published: 1 January 1966 PDF DownloadLoading ...