tbuckley/cabot-search huggingface dataset:
Abstract B08: Tipping the balance: Factors that influence the ER signaling network in breast cancer
Authors: Jeff S. Jasper
Journal: Cancer Research (2013)

Abstract Our lab has generated a tamoxifen resistant cell line (TamR) from MCF7 cells by serial passage in a nude xenograft model in the presence of tamoxifen. The TamR tumor model is stimulated by tamoxifen and does not require estradiol for growth. Transcriptional control of ER in this model is shifted to a ligand-independent state as ER target genes are basally increased and do not induce much higher with estradiol or tamoxifen. We hypothesized that the transcriptional program of ER was altered and that candidate factors could be identified with DNase Hypersensitivity analysis by DNase-Seq. Following Identification of DNase Hypersensitivity Regions, motif enrichment analysis, footprinting, and comparison to to known ChIP-Seq data were performed. These analyses indicate a an increased role for the FOXA family members and RNA-Seq indicates a dramatic upregulation of the FOXA2 transcript. Studies are ongoing to determine the relevance of FOXA2 in tamoxifen resistance and impact on the ER transcriptional program. Citation Format: Jeff S. Jasper. Tipping the balance: Factors that influence the ER signaling network in breast cancer. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr B08.
CLINICAL MANIFESTATIONS OF THE EARLY STAGES OF CIRRHOSIS OF THE LIVER.
Authors: FRANK BILLINGS
Journal: JAMA (1902)

Among my ambulatory patients, especially in the office, I have been surprised to find a relatively large number who have applied for relief of various symptoms in whom a palpable, usually tender and enlarged liver could be demonstrated. The symptoms, in the main, were in many patients those of neurasthenia, in others myalgia or a mono-neuritis, or, most frequently, some gastro-intestinal disturbance. In a few cases arthritis was complained of and the affected joints showed evidence of that trouble. <h3>AN ILLUSTRATIVE CASE.</h3><h3>Case 1.</h3> —B. M. F., aged 54, male, lumber dealer, residence Chicago. The father died of tuberculosis. No other history of inherited disease in the family. Has used alcohol to a very moderate and irregular degree. Smokes moderately. <h3>Previous Sickness.</h3> —The patient had typhoid fever when 15, from which he made a good recovery and enjoyed perfect health until about 20 years ago. Since that time he has
Reactive oxygen species production is increased in the peripheral blood monocytes of obese patients
Authors: Giovanna R. Degasperi, Raphael G.P. Denis, Joseane Morari, Carina Solon, Bruno Geloneze, Christiane Stabe, José Carlos Pareja, Aníbal E. Vercesi, Lício A. Velloso
Journal: Metabolism (2009)
Clinical Lecture on the Consequences of Long Continued Constipation
Authors: J. S. Bristowe
Journal: BMJ (1885)

CASE I. Fwcal Accumulation in Colon forming a Tttmour.-Alittle more than five years ago, while rt the seaside, I was requested by tho local medical man to see a patient with him.This was a married lady, about 30 years of age, who had for the most part had good health, and was the mother of several children.She had been sulTering for about a week from abdominal pain, sickness, an<d disturbance of the bowels; and, now that she was recovering, a tumour had been detected within the abdomen.This discovery caused some alarm; and it was mainly in reference to this that my opinion was desired.She was a healthy looking, somewlhat plump young woman when I saw her; and had then no particular complaint to make.But there was a hard rounded mass in the upper part of the left side of the abdomen, between the unibilicus and the ribs.This was not tender on pressure, was freely movable within narrow limits, and perhaps about 2i inches in diameter.Althouigh rather larger and rounder than a healthy kidney might have been expected to be, I was inclined at the time to think it was a movable kidney.The urine was healthy.A week later, I saw the lady again.She was then in her usual health; but on examining the abdomen, the tumour was still there.Strange to say, however, it had shifted its position; for it now lay ill the centre of the abdomen immediately subjacent to the umbilicus ; and, although still freely movable in a restricted space, it could not by any manceuvre be restored to the region which it had formerly occupied.This circumstance led me to modify my original opinion, and to think itprobable that the tumour was a lump of solid fiecal matter, which had descended within the week from the descending colon into the sigmoid flexure.This opinion was confirmed by -s'hat I now, for the first time, learnt of her history.She had suffered, since her marriage, from persistent constipation; and after one of her confinements (I think the first), an enormous accumulation of solid feical matter had to be removed, partly by mechanical means, from the lower bowel.Eversince that time, her bowels had been exceedingly sluggish.I did not see the patient again for three months.I had returned to town, and she to her home in the south-west of England.On this occasion, she had come to London to consult Sir James Paget, and I Wa asked to meet him.During the interval, she had, in the belief that the tumour was faecal, been treated very actively with enemata, administered by the long tube, and powerful purgatives, including croton-oil.This treatment had pulled her down a good deal, but had not dispersed the presumed accumnulation.At this interview, I learnt that the rectunm was very roomy, and that the tumour could at times be felt descending into the pelvis.It was now entirely below the umbilicus, lying between this and the left Poupart's ligament.
Abstract 2018: Comparison of Risks and Clinical Predictors of Contrast Induced Nephropathy in Patients Undergoing Primary versus Elective Percutaneous Coronary Intervention
Authors: Eric Chong, Liang Shen, Kian K Poh, Hean Y Ong, Chao Y Soon, Huay C Tan
Journal: Circulation (2008)

Background: Contrast nephropathy (CIN) post percutaneous coronary intervention (PCI) increases adverse clinical outcomes. We examine and compare the risks and clinical predictors of CIN among patients who undergo primary versus elective PCI and the effectiveness of prophylactic treatments. Methods: A cohort of 8798 patients who underwent PCI from May 1996 to April 2008 were enrolled. We divided patients into 3 groups(Grp). A: STEMI patient undergoing primary PCI. B: NSTEMI patients undergoing early elective PCI. C: stable patients without myocardial infarction(MI) undergoing elective PCI. Prophylactic saline hydration and oral N-acetylcysteine (NAC) treatment were given to Grp B and C if they have baseline renal impairment (glomerular filtration rate, GFR ≤60ml/min/1.73m 2 ). Grp A patients were unable to receive pre-PCI prophylaxis due to emergency situation. The occurrence of CIN and mortality were compared among 3 grps. Results: Mean age was 57.4±11.1 years. 3146(35.9%) were diabetics. CIN occurred in 12.0% vs. 9.2% vs. 4.5% p=&lt;0.0005, in Grp A, B, C respectively. CIN correlated with increased mortality (15.5% vs. 1.3% p&lt;0.0005) at 1 month. Significant risk predictors of CIN are shown in table Incidence of CIN categorized according baseline renal function based on GFR range are shown in table Clinical predictors of CIN Incidence of CIN categorized by different GFR subgroups Conclusion: Saline and NAC prophylaxis are effective in preventing CIN in milder renal impaired patients (GFR 40 – 60) but are less effective in the more severely renal impaired patients (GFR&lt;40). Patients presenting with STEMI undergoing primary PCI are at the highest risk for development of CIN. Accelerated prophylactic therapy need to be developed to reduce CIN in this cohort. Table 1 Table 2
Environmental bacteria and childhood asthma
Authors: M. J. Ege, M. Mayer, K. Schwaiger, J. Mattes, G. Pershagen, M. van Hage, A. Scheynius, J. Bauer, E. von Mutius
Journal: Allergy (2012)

Abstract Background We have previously found an inverse association of bacterial diversity with childhood asthma. It remains unclear whether certain bacteria account for the protective effect. Methods The high variability of the bacterial 16S rRNA gene allows assessing diversity and specificity of bacterial communities by single‐strand configuration polymorphism ( SSCP ). DNA was extracted from mattress dust samples of 489 school‐age children from rural and suburban regions in Germany. A fragment of the bacteria‐specific 16 S rRNA gene was amplified by PCR , digested to single‐strand DNA , and subjected to electrophoresis. The resulting band patterns reflect the underlying DNA sequences. The individual bands were tested for associations with asthma, hay fever, and atopy in quantitative and qualitative multivariable analyses. Significantly associated bands were isolated and sequenced. The sequences were compared to a database, and distinct bacteria were identified. Results Seven of 76 independent bands were found to be inversely associated with asthma, atopic sensitization, and hay fever with odds ratios ranging from 0.17 to 0.73. The bands contained the sequences of A cinetobacter sp., L actobacillus spp., N eisseria spp., S taphylococcus sciuri , J eotgalicoccus sp., C orynebacterium spp., and others. Conclusions In a diverse microbial environment, certain bacteria may account for the protective effect on the development of asthma and atopy.
An example of access-consciousness without phenomenal consciousness?
Authors: Joseph E. Bogen
Journal: Behavioral and Brain Sciences (1997)

Both Block and the commentators who accepted his P versus A distinction readily recognize examples of P without A but not vice versa. As an example of A without P, Block hypothesized a “zombie,” computationally like a human but without subjectivity. This would appear to describe the disconnected right hemisphere of the split-brain subject, unless one alternatively opts for two parallel mechanisms for P?
Coagulation studies in thrombotic thrombocytopenic purpura, with special reference to von willebrand factor and protein S
Authors: Hoyu Takahashi, Wataru Tatewaki, Tadao Nakamura, Masaharu Hanano, Ken Wada, Akira Shibata
Journal: American Journal of Hematology (1989)

Abstract The profile of blood coagulation and fibrinolysis was studied in detail in eight patients with acute thrombotic thrombocytopenic purpura (TTP). In the majority of the patients, fibrinogen, factor XIII, antithrombin III, α 2 ‐plasmin inhibitor, plasminogen, and α 2 ‐macroglobulin were normal, whereas FDP, plasmin‐α 2 ‐plasmin inhibitor complex, and tissuetype plasminogen activator antigen were marginally or moderately elevated. Low fibronectin values were observed in four patients. Protein C and C4b‐binding protein were nearly normal, whereas total protein S and free protein S were reduced in five and six patients, respectively. A positive correlation was found between total protein S and C4 and between free protein S and C3. von Willebrand factor antigen (vWf:Ag) and ristocetin cofactor (RCof) were either normal or elevated, but RCof/vWf:Ag ratio was decreased in seven patients. Crossed immunoelectrophoresis and sodium dodecyl sulfate (SDS)‐agarose gel electrophoresis revealed that the large vWf multimers were either absent from or relatively decreased in all patients except one. In addition, one patient had unusually large vWf multimers, and a low‐molecular‐weight vWf fragment was apparently observed in three patients. These findings indicate that the intravascular generation of thrombin and plasmin was minimal in TTP and suggest that the alterations of the vWf molecule were caused not only by consumption through its participation in platelet thrombus formation but also by accelerated proteolysis. Low protein S values would be related to the immunological abnormalities underlying TTP.
Significant Reduction of Antibiotic Use in the Community after a Nationwide Campaign in France, 2002–2007
Authors: Elifsu Sabuncu, Julie David, Claire Bernède-Bauduin, Sophie Pépin, Michel Leroy, Pierre-Yves Boëlle, Laurence Watier, Didier Guillemot
Journal: PLoS Medicine (2009)

Background Overuse of antibiotics is the main force driving the emergence and dissemination of bacterial resistance in the community. France consumes more antibiotics and has the highest rate of beta-lactam resistance in Streptococcus pneumoniae than any other European country. In 2001, the government initiated “Keep Antibiotics Working”; the program's main component was a campaign entitled “Les antibiotiques c'est pas automatique” (“Antibiotics are not automatic”) launched in 2002. We report the evaluation of this campaign by analyzing the evolution of outpatient antibiotic use in France 2000–2007, according to therapeutic class and geographic and age-group patterns. Methods and Findings This evaluation is based on 2000–2007 data, including 453,407,458 individual reimbursement data records and incidence of flu-like syndromes (FLSs). Data were obtained from the computerized French National Health Insurance database and provided by the French Sentinel Network. As compared to the preintervention period (2000–2002), the total number of antibiotic prescriptions per 100 inhabitants, adjusted for FLS frequency during the winter season, changed by −26.5% (95% confidence interval [CI] −33.5% to −19.6%) over 5 years. The decline occurred in all 22 regions of France and affected all antibiotic therapeutic classes except quinolones. The greatest decrease, −35.8% (95% CI −48.3% to −23.2%), was observed among young children aged 6–15 years. A significant change of −45% in the relationship between the incidence of flu-like syndromes and antibiotic prescriptions was observed. Conclusions The French national campaign was associated with a marked reduction of unnecessary antibiotic prescriptions, particularly in children. This study provides a useful method for assessing public-health strategies designed to reduce antibiotic use.
Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival.
Authors: Y Maeda, M Matsumoto, O Hori, K Kuwabara, S Ogawa, S D Yan, T Ohtsuki, T Kinoshita, T Kamada, D M Stern
Journal: The Journal of Experimental Medicine (1994)

To elucidate mechanisms underlying neuroprotective properties of astrocytes in brain ischemia, production of neurotrophic mediators was studied in astrocytes exposed to hypoxia/reoxygenation (H/R). Rat astrocytes subjected to H/R released increased amounts of interleukin (IL) 6 in a time-dependent manner, whereas levels of tumor necrosis factor and IL-1 remained undetectable. IL-6 transcripts were induced in hypoxia and the early phase of reoxygenation, whereas synthesis and release of IL-6 antigen/activity occurred during reoxygenation. Elevated levels of IL-6 mRNA were due, at least in part, to increased transcription, as shown by nuclear runoff analysis. The mechanism stimulating synthesis and release of IL-6 antigen by astrocytes was probably production of reactive oxygen intermediates (ROIs), which occurred within 15-20 minutes after placing hypoxia cultures back into normoxia, as the inhibitor diphenyl iodonium inhibited the burst of ROIs and subsequent IL-6 generation (blockade of nitric oxide formation had no effect on ROI generation or IL-6 production). Enhanced IL-6 generation was also observed in human astrocytoma cultures exposed to H/R. Survival of differentiated PC12 cells exposed to H/R was potentiated by conditioned medium from H/R astrocytes, an effect blocked by neutralizing anti-IL-6 antibody. In a gerbil model of brain ischemia, IL-6 activity was lower in the hippocampus, an area sensitive to ischemia, compared with IL-6 activity in the cortex, an area more resistant to ischemia. IL-6 antigen, demonstrated immunohistochemically, was increased in astrocytes from ischemic regions of gerbil brain. These data suggest that H/R enhances transcription of IL-6, resulting in increased translation and release of IL-6 antigen after the burst of ROI generated early during reoxygenation. Release of IL-6 from astrocytes could exert a paracrine neurotrophic effect in brain ischemia.
Conn's Sudden Labial Edema
Authors: JAY W. MARKS
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 November 1971Conn's Sudden Labial EdemaJAY W. MARKS, M.D., FRANKLIN WEIL, M.D.JAY W. MARKS, M.D.Search for more papers by this author, FRANKLIN WEIL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-810_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article by Dr. H. Conn in the June ANNALS (74:943-945, 1971) on the syndrome of sudden scrotal edema after abdominal paracentesis.Recently we observed a patient with this syndrome.The patient was a 46-year-old woman with a long alcoholic history, hepatosplenomegaly, dermatologic manifestations of chronic liver disease, and laboratory data consistent with chronic liver disease. She presented with moderate ascites, and a diagnostic paracentesis was done. Local infiltrative anesthesia was given with a 25-gauge needle, and 100 milliliters of the fluid was removed with an 18-gauge needle and syringe. Thirty-six hours later... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAY W. MARKS, M.D.; FRANKLIN WEIL, M.D.Affiliations: Cedars-Sinai Medical Center Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPost-paracentesis scrotal edema: A case reportPostparacentesis Genital EdemaUnilateral vulvar edema after operative laparoscopy: A case report and literature reviewPostlaparoscopic Vulvar Edema, a Rare ComplicationPostparacentesis bilateral massive vulvar edema in a patient with severe ovarian hyperstimulation syndromeScrotal Edema: Beyond OmegaLORENZO D. MASSEY, M.D. 1 November 1971Volume 75, Issue 5Page: 810-810KeywordsAlcoholicsAnesthesiaAscitesChronic liver diseaseEdemaHepatosplenomegalyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 November 1971 PDF downloadLoading ...
Thrombocytopenia in HIV-infected and uninfected hemophiliacs
Authors: W.C. Ehmann, C.S. Rabkin, M.E. Eyster, J.J. Goedert
Journal: American Journal of Hematology (1997)

To determine the incidence and prognostic significance of thrombocytopenia among hemophiliacs, we analyzed clinical and hematologic data from the Multicenter Hemophilia Cohort study. Nineteen percent of HIV-infected subjects had thrombocytopenia (platelet count of <100,000/mm3) noted at least once, compared to 3% of HIV-uninfected subjects. For HIV-infected subjects, the prevalence of thrombocytopenia rose in the first 5 years after seroconversion and was twice as common in subjects age >35 years compared to younger subjects. The risk increased after an AIDS-defining illness, particularly among older subjects, nearly one-half of whom had thrombocytopenia within 1 year after AIDS. When adjusted for age and CD4-positive lymphocyte counts, thrombocytopenia was associated with an increased risk of death [relative risk (RR) 1.7, 95%Cl = 1.2–2.3] but with little change in the risk of progression to AIDS (RR = 1.2, 95%Cl = 0.8–1.7). Treatment with zidovudine was associated with a decreased risk of thrombocytopenia (RR = 0.5, 95%Cl = 0.3–0.7). Although 59 HIV-infected subjects died of hemorrhage, only 11 (19%) of the 59 had a reported platelet count of <50,000/mm3, and only 2 (3%) of the deaths were temporally associated with thrombocytopenia. Thus, the risk of death was increased for thrombocytopenia HIV-infected hemophiliacs but this was not explained by an increased risk of developing AIDS and was rarely associated with death from bleeding. Am. J. Hematol. 54:296–300, 1997. © 1997 Wiley-Liss, Inc.
Changes in Heart Size in the Dyspnoeic Newborn Baby
Authors: E. D. Burnard
Journal: BMJ (1959)

In a previous paper (Burnard, 1959) the relationship was discussed between symptoms and the crescendo systolic murmur in the newborn baby.Changes in heart size are considered in the present paper, and an explanation is offered of the similarities in symptomatolpgy and necropsy findings between the full-term baby who has suffered asphyxia at birth and the premature baby.Particular importance is attached to the association between murmur, breathlessness, and cardiac enlargement.Method and MaterialForty-nine premature babies were radiographed on one or more occasions in the first seven days of life.Dyspnoea was taken to be present when there was an expiratory grunt or a rate of breathing above 50 a minute.The examinations were made according to the
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids.
Authors: J McLaren, A Prentice, D S Charnock-Jones, S A Millican, K H Müller, A M Sharkey, S K Smith
Journal: Journal of Clinical Investigation (1996)

Angiogenesis is important in the pathophysiology of endometriosis, a condition characterized by implantation of ectopic endometrium in the peritoneal cavity. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved in physiological and pathological angiogenesis, and elevated levels of VEGF are found in peritoneal fluid of patients with endometriosis. Our aim was to investigate the site of expression and regulation of VEGF in endometriosis. VEGF immunoreactivity was found in tissue macrophages present in ectopic endometrium and in activated peritoneal fluid macrophages. Macrophage activation was highest in women with endometriosis, and media conditioned by peritoneal fluid macrophages from these women caused a VEGF-dependent increase in endothelial cell proliferation above that seen from normal women. Peritoneal fluid macrophages secreted VEGF in response to ovarian steroids, and this secretion was enhanced after activation with lipopolysaccharide. Peritoneal fluid macrophages expressed receptors for steroid hormones. VEGF receptors flt and KDR (kinase domain receptor) were also detected, suggesting autocrine regulation. During the menstrual cycle, expression of flt was constant but that of KDR was increased in the luteal phase, at which time the cells migrated in response to VEGF. KDR expression and the migratory response were significantly higher in patients with endometriosis. This study demonstrates that activated macrophages are a major source of VEGF in endometriosis and that this expression is regulated directly by ovarian steroids.
Ataxia telangiectasia mutated–deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage
Authors: Tatjana Stankovic, Grant S. Stewart, Christopher Fegan, Paul Biggs, James Last, Philip J. Byrd, Russell D. Keenan, Paul A. H. Moss, Alexander M. R. Taylor
Journal: Blood (2002)
CYCLOSPORIN IN BEHÇET'S DISEASE
Authors: C. Ffrench-Constant, R. Wolman, D. Geraint James, M.D. Sanders, D. Geraint James, Elizabeth Graham, J. Acheson, D.C. Dumonde, E. Kasp-Grochowska, A. Hamblin, A. Singh
Journal: The Lancet (1983)
Book: The Cure: A Story of Cancer and Politics from the Annals of the Cold War
Authors: R. Camidge
Journal: BMJ (2002)

Nikolai Krementsov University of Chicago Press, $26/£16.50, pp 277 ISBN 0 226 45284 0 Rating: ![Graphic][1]</img> At the end of the second world war, when Russia drew an “iron curtain” across Europe, the secret of atomic power was known only on the Western side. While espionage inevitably proved the most successful strategy in the long run, Russia's earlier plan to acquire this information by swapping it for its own top secret cure for cancer sounds like a great idea for a book, maybe even for a Hollywood film. Unfortunately, the high drama of these events … [1]: /embed/inline-graphic-1.gif