tbuckley/cabot-search huggingface dataset:
799-5 Point Mutations of Mitochondrial DNA in Alcoholic Heart Muscle Disease
Authors: Masakazu Teragaki, Masahiko Takagi, Tomoko Tani, Minoru Yoshiyama, Iku Toda, Kaname Akioka, Kazuhide Takeuchi, Tadanao Takeda, Masashi Tanaka, Takayuki Ozawa
Journal: Journal of the American College of Cardiology (1995)
Multiple Myeloma in Young Persons
Authors: JOSEPH KAPLAN
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 July 1976Multiple Myeloma in Young PersonsJOSEPH KAPLAN, M.D.JOSEPH KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-1-133_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent paper (Ann Intern Med 84: 441-443, 1975) He well and Alexanian presented three cases of multiple myeloma in young persons, claiming that before their report "no well-documented patients with myeloma have been described under the age of 30."In fact, there is a well-documented case of childhood multiple myeloma in the recent literature. Maeda and associates (1) described a 13-year-old girl with subcutaneous breast tumors whose bone marrow revealed more than 90% immature plasma cells. These abnormal cells were identical to those seen in the biopsy of subcutaneous tissue. In addition, a monoclonal IgA...Reference1. MAEDAABESAMISKUHN KCM: Multiple myeloma in childhood: report of a case with breast tumors as a presenting manifestation. Am J Clin Pathol 60:552-558, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCross-sectional study of 100 cases of newly diagnosed plasma cell neoplasms in a tertiary care setup 1 July 1976Volume 85, Issue 1Page: 133-133KeywordsBiopsyBone marrowBreast cancerCellsMultiple myelomaMyelomaPlasma cells ePublished: 1 December 2008 Issue Published: 1 July 1976 PDF downloadLoading ...
Neck muscle activity in patients with severe chronic obstructive pulmonary disease.
Authors: A De Troyer, R Peche, J C Yernault, M Estenne
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

The present studies were designed to assess the pattern of activity and the frequency of activation of the neck muscles in patients with chronic obstructive pulmonary disease (COPD). Using concentric needle electrodes, we thus recorded the electromyograms of the scalene, sternocleidomastoid, and trapezius muscles during resting breathing in 40 stable patients with severe chronic airflow obstruction (FEV1 = 0.69 +/- 0.18 L) and hyperinflation (FRC = 228 +/- 40% of predicted); 17 patients were hypercapnic at rest. When breathing in the seated posture, all patients (100%) had strong inspiratory contraction of the scalenes. In contrast, no patient showed inspiratory activity in the trapezius, and only four patients (10%) showed definite, invariable inspiratory activity in the sternocleidomastoid. These two muscles were silent in the supine posture as well, even though the adoption of this posture was associated with an increase in dyspnea in most patients. We conclude, therefore, that in contrast to conventional thinking, most stable patients with severe COPD do not use the sternocleidomastoids or the trapezii when breathing at rest. Additional measurements indicated that the sternocleidomastoid inspiratory activity previously recorded in such patients was in general caused by a cross-contamination from surrounding muscles.
Tumor monocyte cross talk promotes lymphoma cell resistance to chemotherapy
Authors: Zhe (Jenny) Zhang, Peggy A Bulur, Michael P Gustafson, Dennis A Gastineau, Allan B Dietz, Yi Lin
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Immune editing is a major mechanism used by tumors to promote its survival. We have reported previously the presence of a novel phenotype of immunosuppressive monocytes (CD14+HLA-DR low/neg) in a number of cancers. Increased presence of these cells was associated with decreased
Influence of coronary heart disease on morbidity and mortality after carotid endarterectomy: A population-based study in Olmsted County, Minnesota (1970–1988)
Authors: Charanjit S. Rihal, Bernard J. Gersh, Jack P. Whisnant, Thom W. Rooke, Thoralf M. Sundt, W.Michael O'Fallon, David J. Ballard
Journal: Journal of the American College of Cardiology (1992)
Risk of Elective Major Noncardiac Surgery After Coronary Stent Insertion
Authors: Duminda N. Wijeysundera, Harindra C. Wijeysundera, Lingsong Yun, Marcin Wąsowicz, W. Scott Beattie, James L. Velianou, Dennis T. Ko
Journal: Circulation (2012)

Guidelines recommend that noncardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and 1 year after drug-eluting stent implantation.We used linked registry data and population-based administrative health care databases to conduct a cohort study of 8116 patients (≥40 years of age) who underwent major elective noncardiac surgery in Ontario, Canada between 2003 and 2009, and received coronary stents within 10 years before surgery. Approximately 34% (n=2725) underwent stent insertion within 2 years before surgery, of whom 905 (33%) received drug-eluting stents. For comparison, we assembled a separate cohort of 341 350 surgical patients who had not undergone coronary revascularization. The primary outcome was 30-day major adverse cardiac events (mortality, readmission for acute coronary syndrome, or repeat coronary revascularization). The overall rate of 30-day events in patients with coronary stents was 2.1% (n=170). When the interval between stent insertion and surgery was <45 days, event rates were high for bare-metal (6.7%) and drug-eluting (20.0%) stents. When the interval was 45 to 180 days, the event rate for bare-metal stents was 2.6%, approaching that of intermediate-risk nonrevascularized individuals. Adjusted analyses suggested that event rates were increased if this interval exceeded 180 days. For drug-eluting stents, the event rate was 1.2% once the interval exceeded 180 days, approaching that of intermediate-risk nonrevascularized individuals.The earliest optimal time for elective surgery is 46 to 180 days after bare-metal stent implantation or >180 days after drug-eluting stent implantation.
PROPHYLAXIS OF MALIGNANT GROWTHS OF THE MOUTH, FACE AND JAWS
Authors: JOSEPH RILUS EASTMAN
Journal: JAMA (1922)

Little more is known of the origin and nature of cancer than was known many years ago. Clinical considerations and experimental observations have accumulated which have enriched the literature of this subject, but the incidence of cancer increases. Although this is both appalling and true, there is, nevertheless, reason to believe that, out of the spirit of sacrifice and the genius of persistence of the laborers in this field of research, a solution will come eventually. The united efforts of pathologists, clinicians, statisticians and general practitioners will finally unravel the mystery of cancer, and probably through the study of the four factors of incidence, heredity, agency of transmission and pathology.  It is perhaps to the experiments of the laboratory that we look with the greatest confidence; but the clinical notations of the physician and surgeon who deal with cancer in man must be deemed of interest and importance.  Gully emphasizes
Plasma Endothelinlike Immunoreactivity Levels in IDDM Patients with Microalbuminuria
Authors: Andrew Collier, John P Leach, Alistair McLellan, Alan Jardine, James J Morton, Michael Small
Journal: Diabetes Care (1992)

OBJECTIVE To determine whether plasma endothelin, a potent vasoconstrictor and growth factor for vascular smooth muscle, is elevated in microalbuminuric insulin-dependent diabetes mellitus patients. RESEARCH DESIGN AND METHODS Plasma endothelinlike immunoreactivity was measured by radioimmunoassay in 15 microalbuminuric diabetic patients, 12 normoalbuminuric diabetic patients, and 12 control subjects. RESULTS The mean levels of plasma endothelinlike immunoreactivity were raised in the normoalbuminuric patients (8.4 pM [range 4.8–12.7 pM]; P &amp;lt; 0.01) and the microalbuminuric patients (10.2 pM [range 5.6–31.1 pM]; P &amp;lt; 0.001) compared with control subjects (6.1 pM [range 4.5–7.6 pM]). Plasma endothelinlike immunoreactivity was also higher in the microalbuminuric patients compared with the normoalbuminuric patients (P &amp;lt; 0.05). CONCLUSIONS The increase in plasma endothelinlike immunoreactivity further confirms endothelial dysfunction in diabetes and this increase in plasma endothelin may contribute to the vascular disease prevalent in diabetes.
Teaching Family Medicine
Authors: Lynn P. Carmichael
Journal: JAMA (1965)

Medical education is concerned with the future, that is, the production of physicians for the future. The role of the medical practitioner will depend upon the medical needs of the community he is to serve. An implicit obligation of medical educators is to define these needs, and act accordingly. <h3>The Needs of the Public.—</h3> This is a period of rapid social change. Traditional virtues and standards of conduct are being discarded. Society is becoming more diversified and complex, more interrelated and interdependent. Our population is expanding. We live longer, have a higher standard of living, and enjoy more leisure. The work we do is more productive and yet easier. All of this will affect medical practice of the future, but even more significant are the changes occurring in the American family. Marriage was never more popular, nor held in higher esteem by both men and women. An expression of this
TUBERCULOUS EFFUSION, TRAUMATIC IN ORIGIN
Authors: H. A. BRAY
Journal: JAMA (1918)

The case here recorded illustrates the reawakening by trauma of a previous benign tuberculous pleurisy in an apparently healthy person. It also tends to confirm clinically recent experiments on pigs in regard to the pleural reaction in tuberculosis. <h3>REPORT OF CASE</h3><h3>History.</h3> —Mrs. L., aged 36, married, housewife, is a large robust woman, weighing 185 pounds. The paternal grandmother, mother and one brother died of pulmonary tuberculosis, and the patient was definitely exposed to this disease for a period of years during childhood. Otherwise the family history is unimportant. Since the age of 16 she has had repeated attacks of quinsy, and for some years past during the winter months has suffered from recurring attacks of bronchitis. In 1912, three years previous to the present illness, the patient came to me complaining of pelvic discomfort due to prolapsus uteri. At this time an examination of the chest, suggested by the
Guides to the Evaluation of Permanent Impairment
Authors: Mark Battista
Journal: JAMA (1985)

Provided to all who attended the June 1984 American Medical Association (AMA) Conference on Impairment and Disability, this second edition of the<i>Guides</i>, the result of several years of work by AMA staff in conjunction with numerous experts, will be, like the first edition, a major part of the available literature on evaluating impairments. Its 12 chapters range from a 60-page section on "The Extremities, Spine, and Pelvis" to a six-page section on "The Hematopoietic System" and cover all systems. A minor change in chapter headings includes the transformation of "Mental Illness" into "Mental and Behavioral Disorders"; the chapter has been rewritten extensively and represents a major change in conceptual approach. There is a succinct appendix describing the essentials of reporting of impairments and an important new addition on the evaluation of "Sleep and Arousal Disorders." As stated in the preface, "the principal use of a medical rating of permanent
Bad Outcomes of Questionable Medical Decisions
Authors: Timothy P. Hofer, Rodney A. Hayward
Journal: Annals of Internal Medicine (2003)

Letters18 March 2003Bad Outcomes of Questionable Medical DecisionsTimothy P. Hofer, MD, MS and Rodney A. Hayward, MDTimothy P. Hofer, MD, MSVA Center for Practice Management and Outcomes Research; Ann Arbor, MI 48113 (Hofer, Hayward)Search for more papers by this author and Rodney A. Hayward, MDVA Center for Practice Management and Outcomes Research; Ann Arbor, MI 48113 (Hofer, Hayward)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-6-200303180-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Kessler argues that in the patient we discussed, a more conservative approach to managing pericardial effusion would have been preferable. The cardiologist in this case (who was also a respected clinician at a respected institution) made a different decision. Our experience in formal studies of physician peer review suggests that reviewers make highly variable assessments in most episodes of patient care (1). Assessments of clinical decision making are not very precise, although there is evidence that they are valid in that they correlate with other measures of quality (2). Dr. Kessler also suggests that errors should be ...References1. Hayward RA, Hofer TP. Estimating hospital deaths due to medical errors: preventability is in the eye of the reviewer. JAMA. 2001;286:415-20. [PMID: 11466119] CrossrefMedlineGoogle Scholar2. Rubenstein LV, Kahn KL, Reinisch EJ, Sherwood MJ, Rogers WH, Kamberg C, et al. . Changes in quality of care for five diseases measured by implicit review, 1981 to 1986. JAMA. 1990;264:1974-9. [PMID: 2214062] CrossrefMedlineGoogle Scholar3. Hofer TP, Kerr EA, Hayward RA. What is an error? Eff Clin Pract. 2000;3:261-9. [PMID: 11151522] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Timothy P. Hofer, MD, MS; Rodney A. Hayward, MDAffiliations: VA Center for Practice Management and Outcomes Research; Ann Arbor, MI 48113 (Hofer, Hayward) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAre Bad Outcomes from Questionable Clinical Decisions Preventable Medical Errors? A Case of Cascade Iatrogenesis Timothy P. Hofer and Rodney A. Hayward Bad Outcomes of Questionable Medical Decisions Kenneth M. Kessler Bad Outcomes of Questionable Medical Decisions Elizabeth Nilson Bad Outcomes of Questionable Medical Decisions William B. Weeks and James P. Bagian Metrics Cited byA Comparison of Total Hip and Knee Replacement in Specialty and General Hospitals 18 March 2003Volume 138, Issue 6 Page: 520 Keywords Adverse events Decision making Extrapolation Hip Patients Peer review Safety Safety studies ePublished: 18 March 2003 Issue Published: 18 March 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Health Care Tickets for the Uninsured
Authors: H. Gilbert Welch
Journal: New England Journal of Medicine (1989)

The problem of providing health care for the uninsured has recently given rise to a number of proposals aimed at making health insurance more universally available. In the past year, national health insurance,1 a consumer-choice plan using employer-based health insurance,2 and an expansion of Medicaid known as the Health Policy Agenda3 , 4 have all been suggested. Each of these proposals devotes considerable attention to questions of cost and funding, but less attention has been given to the question of what should be purchased. This commentary focuses on the question of what coverage can be provided for the uninsured and seeks to . . .
Prostatic Resection: A Simplified Technique
Authors: C. D. Maitland
Journal: BMJ (1936)

M 60&chordotomy that complete freedom from pain can be promised, but as the operation is a severe one it should be reserved for exceptional cases.In my own experience the necessity for chordotomy has only arisen once. Treatment by RadiotherapyTwo alternative lines of treatment are here available: radium and deep x-ray therapy.If the former be selected '.
Transsphenoidal Radiation Hypophysectomy with Gold-198
Authors: George B. Udvarhelyi
Journal: JAMA (1962)

The transsphenoidal implantation of radioactive gold (Au<sup>198</sup>) into the anterior lobe of the pituitary was carried out in 39 patients with advanced carcinoma. The radiation from 25 mc. of the isotope so applied did not achieve total destruction of the pituitary but did relieve pain in two-thirds of the patients. Evidence that vision was improved or metastasis retarded was obtained in 6 of the 39 patients.
Toward Greater Patient Safety
Authors: Denis Abelson
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Few would dispute that a patient who is liable to cardiac arrest should be at least as safe in the hospital as he is while en route in the ambulance. Unfortunately, there have been several recorded instances of cardiac arrest occurring while the patient was being transported from one part of the hospital to another, eg, from the emergency room to the coronary care unit, without emergency resuscitation equipment being immediately at hand. To meet this contingency, specially constructed stretchers are now available in which the necessary equipment is located underneath. At the Lankenau Hospital, we have designed a "ResusciTable"* that can be placed over the patient's legs as he lies on any standard stretcher (Figure). On the front is mounted an aneroid blood pressure gauge with a large dial. Drugs and small items of equipment are stored in a drawer, which can be opened from either
Mandela calls for greater investment in global vaccination
Authors: J. Clark
Journal: BMJ (2002)

Former South African president Nelson Mandela has called for action by private and public organisations to promote vaccination and save the 8000 children who die every day from diseases that can be prevented by vaccines.

His call follows publication of a World Health Organization report highlighting the growing gap between rich and poor countries in access to vaccination. Low investment by donors is a major reason for this, says the report.

In a foreword to the report, Mr Mandela, chairman of the Vaccine Fund Board, urges international organisations and governments to “meet your moral …
Laboratory assessment of the efficiency of encasing materials against house dust mites and their allergens
Authors: V. Mahakittikun, C. Komoltri, H. Nochot, A. C. Angus, F. T. Chew
Journal: Allergy (2003)

Background: The current recommendation to reduce mite allergen exposure for mite‐sensitive individuals is to use allergen‐impermeable bed coverings. As these covers are made of various kinds of materials, they vary in quality. The objective of this study was to investigate the efficiency of different covering materials against house dust mites and their allergens in vitro . Methods: Four types of materials including (1) plastic cover, (2) polyurethane‐coated cover, (3) non‐woven covers, (4) tightly woven microfiber covers and a regular cotton bed sheet (as a control) were evaluated using three methods: (i) heat escape method, (ii) Siriraj chamber method and stereomicroscopy, scanning electron microscopy and (iii) enzyme‐linked immunosorbent assay (ELISA). Results: We found that there was a statistically significant difference in allergen permeability among four types of coverings ( P &lt; 0.001). In terms of the impermeability to mites and their allergens, plastic‐ and polyurethane‐coated covers were observed to be the best, followed by non‐woven, woven and cotton‐based bed sheets. A regular cotton‐based bed sheet allows a significant amount of leakage of mite allergens. Both woven and non‐woven material are efficient barriers against mite allergen in terms of impermeability. However, with regard to mite colonization, non‐woven covers have the drawback of mites being able to penetrate and colonize within the fabric fibers. Woven covers are therefore recommended because of their major advantages of not allowing the colonization of mites within the fabric, being easy to clean, and comfortable. Conclusion: The three assessment methods used in this study could be useful as a primary approach to evaluate the quality of covering materials in vitro using both pore size and ability to be colonized by mites on the materials as the key factors.
TCT-592 Ten-year Clinical Outcomes After The First Sirolimus-eluting Stent Implantation: Impact of In-stent Restenosis Lesion
Authors: Katsuya Miura, Kazushige Kadota, Masanobu Ohya, Takenobu Shimada, Yu Izawa, Yusuke Hyodo, Suguru Otsuru, Daiji Hasegawa, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2015)
Consistent beneficial effects of killer cell immunoglobulin‐like receptor 2DL3 and group 1 human leukocyte antigen‐C following exposure to hepatitis C virus
Authors: Susanne Knapp, Usama Warshow, Doha Hegazy, Louise Brackenbury, I. Neil Guha, Andrew Fowell, Ann‐Margaret Little, Graeme J. Alexander, William M.C. Rosenberg, Matthew E. Cramp, Salim I. Khakoo
Journal: Hepatology (2009)

Natural killer cells are a key component in the immune control of viral infections. Their functions are controlled by inhibitory receptors for major histocompatability complex (MHC) class I, including the killer cell immunoglobulin-like receptors (KIR). KIR2DL3 in combination with its cognate human leukocyte antigen (HLA)-C ligand has been shown to be associated with spontaneous resolution of viremia following hepatitis C virus (HCV) infection. In order to determine if this gene combination is advantageous across all potential outcomes following HCV exposure, we studied individuals with apparent resistance to HCV infection who remain seronegative and aviremic despite long-term injection drug use and also individuals chronically infected with HCV who successfully clear HCV with treatment. Homozygosity for KIR2DL3 in combination with group 1 HLA-C allotypes was more frequent in exposed seronegative aviremic individuals as compared to those with chronic HCV (25.0% versus 9.7%, P = 0.003, odds ratio [OR] = 3.1, 95% confidence interval [CI] = 1.3-7.1) in a model similar to that found for those spontaneously resolving HCV. In individuals undergoing treatment for HCV, those with KIR2DL3 and group 1 HLA-C were more likely to make a sustained virological response (SVR) (P = 0.013, OR = 2.3, 95% CI = 1.1-4.5). KIR and HLA-C protection in both treatment response and spontaneously resolving HCV was validated at the allelic level, in which KIR2DL3-HLA-Cw*03 was associated with SVR (P = 0.004, OR = 3.4, 95% CI = 1.5-8.7) and KIR2DL3/KIR2DL3-HLA-Cw*03 was associated with spontaneous resolution of HCV infection (P = 0.01, OR = 2.3, 95% CI = 1.2-4.4). Conclusion: KIR and HLA-C genes are consistently beneficial determinants in the outcome of HCV infection. This advantage extends to the allelic level for both gene families. (HEPATOLOGY 2010.)
An obstructive, proximally migrated plastic biliary stent extracted with a “modified” Seldinger technique and a polypectomy snare
Authors: B. Mangiavillano, E. Masci
Journal: Endoscopy (2007)

Endoscopic retrieval of proximally migrated, plastic biliary stents may be technically challenging and sometimes unsuccessful [1]. Data from the literature report a retrieval success rate of 85%, with the remaining 15% requiring surgical removal [2]. The choice of retrieval technique is dependent on several factors, including biliary ductal dilatation, depth of stent migration, distal stent impaction, and biliary stricture distal to the migrated stent. The placement of an additional stent alongside an irretrievable stent has been reported as an alternative technique to retrieval, but the risk of cholangitis associated with this technique is not yet widely known by practitioners [3]. Despite the widespread use of such stents, there are few reports on the technique and the different accessories available for retrieval of migrated stents. Furthermore, there are no reports in the literature on proximally migrated, biliary stent removal using a polypectomy snare.