tbuckley/cabot-search huggingface dataset:
Does Race Predispose to Angiotensin-Associated Angioneurotic Edema?
Authors: W. Dallas Hall
Journal: Annals of Internal Medicine (1993)

Letters15 December 1993Does Race Predispose to Angiotensin-Associated Angioneurotic Edema?W. Dallas Hall, MD and Zafar H. Israili, MDW. Dallas Hall, MDSearch for more papers by this author and Zafar H. Israili, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-12-199312150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The observation of Drs. Brown and Nadeau is interesting. As they note, the data are insufficient to confirm the observed disparity in the incidence of ACE inhibitor-induced angioneurotic edema between blacks and whites. Angioneurotic edema was not one of the adverse effects reported in a study of 112 black patients with hypertension who were treated with captopril [1]. We agree with Drs. Brown and Nadeau that rigorous pharmacoepidemiologic studies are needed to confirm or refute their observation. It appears that women are at a greater risk for the development of angioneurotic edema from ACE inhibitors [2]. We suggest ...References1. Saunders E, Weir MR, Kong BW, Hollifield J, Gray J, Vertes V, et al. A comparison of the efficacy and safety of a -blocker, a calcium channel blocker, and a converting enzyme inhibitor in hypertensive blacks. Arch Intern Med. 1990; 150:1707-13. Google Scholar2. Israili ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. Ann Intern Med. 1992; 117:234-42. Google Scholar Author, Article, and Disclosure InformationAuthors: W. Dallas Hall, MD; Zafar H. Israili, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1993Volume 119, Issue 12Page: 1224KeywordsACE inhibitorsAngiotensin converting enzymeEdemaHypertensionRacial and ethnic issues ePublished: 15 August 2000 Issue Published: 15 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Tipping the Balance of Autism Risk: Potential Mechanisms Linking Pesticides and Autism
Authors: Janie F. Shelton, Irva Hertz-Picciotto, Isaac N. Pessah
Journal: Environmental Health Perspectives (2012)

Autism spectrum disorders (ASDs) have been increasing in many parts of the world and a portion of cases are attributable to environmental exposures. Conclusive replicated findings have yet to appear on any specific exposure; however, mounting evidence suggests gestational pesticides exposures are strong candidates. Because multiple developmental processes are implicated in ASDs during gestation and early life, biological plausibility is more likely if these agents can be shown to affect core pathophysiological features.Our objectives were to examine shared mechanisms between autism pathophysiology and the effects of pesticide exposures, focusing on neuroexcitability, oxidative stress, and immune functions and to outline the biological correlates between pesticide exposure and autism risk.We review and discuss previous research related to autism risk, developmental effects of early pesticide exposure, and basic biological mechanisms by which pesticides may induce or exacerbate pathophysiological features of autism.On the basis of experimental and observational research, certain pesticides may be capable of inducing core features of autism, but little is known about the timing or dose, or which of various mechanisms is sufficient to induce this condition.In animal studies, we encourage more research on gene × environment interactions, as well as experimental exposure to mixtures of compounds. Similarly, epidemiologic studies in humans with exceptionally high exposures can identify which pesticide classes are of greatest concern, and studies focused on gene × environment are needed to determine if there are susceptible subpopulations at greater risk from pesticide exposures.
Elevated odds of metabolic syndrome in psoriasis: a population‐based study of age and sex differences
Authors: K. Danielsen, T. Wilsgaard, A.O. Olsen, A.E. Eggen, K. Olsen, P.A. Cassano, A.‐S. Furberg
Journal: British Journal of Dermatology (2014)

Questions remain concerning to what extent age and sex may modify the suggested association between psoriasis and the metabolic syndrome in the general population.To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex.A cross-sectional study including 10 521 participants aged 30-79 years from the Tromsø Study cohort was performed; 1137 participants reported lifetime psoriasis of a mainly mild character. The new harmonized definition of metabolic syndrome was used in the multivariable logistic regression analysis.There was a uniformly higher prevalence of metabolic syndrome in men and women with psoriasis compared with those without across all age groups. In women, psoriasis was associated with a 3·8-times higher odds of metabolic syndrome at age 30 years (95% confidence interval 1·5-9·7), with a decreasing odds ratio with increasing age. In men, psoriasis was associated with a stable 1·35-times higher odds of metabolic syndrome (95% confidence interval 1·1-1·6) at all ages. Abdominal obesity was the most frequent metabolic syndrome component in women in this study, and there was indication of a dose-response relationship between psoriasis severity, indicated through treatment, and having a high waistline in women.This study suggests age and sex variations in the risk of metabolic syndrome among individuals with psoriasis. Given the high prevalence of psoriasis and the significantly elevated burden of metabolic syndrome in this patient group, there may be a benefit from targeted screening of metabolic syndrome among individuals with psoriasis regardless of age and disease severity.
Carcinoma of the Eyelid
Authors: Charles G. Stetson, Milford D. Schulz
Journal: New England Journal of Medicine (1949)

THE treatment of carcinoma of the eyelid presents many problems not encountered in the treatment of similar lesions elsewhere about the face and other body surfaces. A satisfactory cosmetic result is imperative, and the likelihood of disaster after delayed, inept or unsuccessful treatment is considerable. Several excellent studies have been carried out on this subject, and all workers of considerable experience have reported poor results in patients who have presented themselves with recurrent or persistent disease following previous therapy in other hands. The purpose of this paper is to evaluate the various methods of treatment of primary carcinoma of the . . .
Cardiac resynchronization therapy with individualized placement of two left ventricular leads at the sites of latest mechanical left ventricular contraction: guided by 3D‐echocardiography and coronary sinus rotation angiography
Authors: Charlotte Eitel, Michael Döring, Thomas Gaspar, Ulrike Wetzel, Roland Bullens, Gerhard Hindricks, Christopher Piorkowski
Journal: European Journal of Heart Failure (2010)
Inhalation of Ethyl Alcohol for Pulmonary Edema
Authors: Abraham Gootnick, Henry I. Lipson, Joseph Turbin
Journal: New England Journal of Medicine (1951)

TREATMENT of experimental pulmonary edema with ethyl alcohol as an antifoaming agent has been described by Luisada.1 However, no clinical experience with this agent has as yet appeared in the literature. The purpose of this paper is to report the addition of ethyl-alcohol inhalation to the therapeutic regimen for pulmonary edema in man and to describe the solution of certain technical problems in the administration of this drug.The conventional management of paroxysmal pulmonary edema has aimed at three goals: depression with morphine or other sedative drugs of the nerve centers involved in the reflex effects on lung capillaries; reduction . . .
Cultural safety and the health of adolescents
Authors: F. A Hughes
Journal: BMJ (2003)

Barriers to providing good health care for adolescents parallel those facing minority groups such as the Maori. Indigenous peoples often feel disenfranchised and dominated by a “foreign” culture. They feel pressure to assimilate into the majority culture, yet the dominant culture shows little respect for or comprehension of their lifestyle. Adolescents experience similar stresses, which manifest as health problems that are classically displayed among oppressed groups: mental health problems, lifestyle disorders (such as obesity), and self harm.

In the late 1980s Maori nurses conceived the idea of “cultural safety” to improve nurses' delivery of health care. The study of its principles is now part of the registration requirement for nurses and midwives. Cultural safety requires healthcare providers to reflect on their own cultural background and the nature of power relations in the provision of services to a minority culture by a dominant culture, so that the providers can …
1302 THE CHARACTERISTIC MECHANISMS OF FREE CHOLESTEROL ACCUMULATION IN HEPATIC STELLATE CELLS AGGRAVATE LIVER FIBROSIS IN NONALCOHOLIC STEATOHEPATITIS IN MICE
Authors: K. Tomita, T. Teratani, T. Suzuki, M. Shimizu, H. Sato, Y. Okada, C. Kurihara, H. Yokoyama, R. Irie, H. Ebinuma, H. Saito, C. Watanabe, S. Komoto, R. Hokari, A. Kawaguchi, S. Nagao, K. Sugiyama, T. Kanai, T. Hibi, S. Miura
Journal: Journal of Hepatology (2013)
Accuracy of Linear Endoscopic Ultrasonography in the Evaluation of Patients with Suspected Common Bile Duct Stones
Authors: M. Kohut, E. Nowakowska-Duława, T. Marek, R. Kaczor, A. Nowak
Journal: Endoscopy (2002)

Background and Study Aims: Endoscopic ultrasonography (EUS) with radial scanning is an efficient diagnostic tool where there is suspicion of common bile duct (CBD) stones. Little is known about the use of linear EUS in this condition. The aim of this study was to evaluate the diagnostic efficiency of linear EUS in a large group of patients suspected to have bile duct stones, using endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy and exploration of the CBD using a Dormia basket, or surgical choledochotomy with choledochoscopy, as diagnostic "gold standards." Patients and Methods: 134 patients with clinical suspicion of CBD stones were included in the study and prospectively evaluated, using EUS, and ERCP with endoscopic sphincterotomy (127 patients), or choledochotomy with choledochoscopy where ERCP was unsuccessful (seven patients). EUS was done before ERCP using an echo endoscope (Pentax FG 32 UA; 5 - 7.5 MHz) and Hitachi EUB 405 ultrasound machine. ERCP was done using the TFJ 100 or TJ 20 Olympus duodenoscope. ERCP was carried out within a mean of 2 days after EUS. The longest time between EUS and ERCP was 3 days. The examiners were blinded to the results of the other method used. Results: CBD stones were found in 91 (68 %) patients at ERCP with ES or at surgery. The correct diagnosis was established by EUS in 85 patients. The remaining 43 patients without CBD stones were correctly diagnosed in 41 cases by means of EUS, giving an accuracy of 94 %, sensitivity of 93 %, specificity of 93 %, a positive predictive value of 98 %, a negative predictive value of 87 %, and a Youden's index of 89 %. Conclusions: Linear EUS is a fairly reliable method for the evaluation of patients with high suspicion for CBD stones. The usefulness of linear EUS in the evaluation of patients with low or moderate suspicion for CBD stones warrants further study.
Avoid 50% dextrose
Authors: M. L. Evans
Journal: BMJ (2011)

<h3>ABSTRACT</h3> Organisms are subject to a host of physical forces that influence morphological evolution. Birds, for instance, use their bills as implements to perform various functions, each exerting unique physical demands and selective influences on bill morphology. For example, birds that use their bills to excavate nesting or roosting cavities must resist a range of mechanical stresses to prevent fracture. However, the contribution of bill geometry and material composition to excavation stress resistance remains poorly understood. Here, we study the biomechanical consequences of bill diversification in two clades of cavity-excavating, frugivorous birds, the paleotropical barbets. Using multilayered finite element models and beam theory, we compare the excavation performance of different maxillary geometries for two loading regimes experienced by barbet bills during cavity excavation-dorsoventral impact and torsion. We find that deeper and wider maxillae perform better for impact loads than for torsional loads, with the converse for narrower maxillae. This results in a tradeoff between impact and torsion resistance imposed by bill geometry. Analytical beam models validate this prediction, showing that this relationship holds even when maxillae are simplified to solid elliptical beams. Finally, we find that composite bill structures broadly exhibit lower stresses than homogenous structures of the same geometry, indicating a functional synergy between the keratinous rhamphotheca and bony layers of the bill. Overall, our findings demonstrate the strong link between morphological evolution, behavior, and functional performance in organisms.
Anorexia nervosa and chronic alcoholism.
Authors: T. Singh
Journal: BMJ (1969)

In a recent survey of 890 Maltese skulls I came across four atlanto-paramastoid articu- lations, one complete synfostosis of the atlanto-paramastoid joint, and one skull (see Fig. ) which showed a right paramastoid process partially fused with but still distinct from the transverse process of the atlas, and a left one in complete synostosis with the atlantal transverse process.Atlanto-paramastoid articulations and synostoses, though relatively rare, may be the cause of mechanical torticollis with chronic pain in the neck and limitation of movement, particularly of nodding of the head at the atlanto-occipital joints.I am, etc.,
Clinical value of I-123 metaiodobenzylguanidine myocardial scintigraphy in patients with acute myocardial infarction
Authors: Hiroshi Itagane, Kaname Akioka, Hisao Oku, Kazuhide Takeuchi, Tadanao Takeda, Hironobu Ochi
Journal: Journal of the American College of Cardiology (1990)
A case for refining the WHO Global Strategy on Food Safety: perspectives from India
Authors: SubbaRao M Gavaravarapu, Katherine C Smith, Rajiv N Rimal
Journal: The Lancet Global Health (2013)

The Lancet Global Health, Volume 1, Issue 5, Pages e254 - e255, November 2013[Close]doi:10.1016/S2214-109X(13)70088-3Copyright © 2013 Gavaravarapu et al. Open Access article distributed under the terms of CC BY-NC-SA Published by ElsevierLtd. All rights reserved.Comment on this article: Join the debate and follow the discussion on The Lancet Global Health Blog.
Effects of Cigarette Smoke in Mice with Different Levels of α<sub>1</sub>-Proteinase Inhibitor and Sensitivity to Oxidants
Authors: ELEONORA CAVARRA, BARBARA BARTALESI, MONICA LUCATTELLI, SILVIA FINESCHI, BENEDETTA LUNGHI, FEDERICA GAMBELLI, LUIS A. ORTIZ, PIERO A. MARTORANA, GIUSEPPE LUNGARELLA
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

The role of strain difference in the response to cigarette smoke was investigated in mice. Mice of the strains DBA/2 and C57BL/6J responded to acute cigarette smoke with a decrease of the antioxidant defenses of their bronchoalveolar lavage (BAL) fluids. On the other hand, under these conditions ICR mice increased their BAL antioxidant defenses. Mice of these three strains were then exposed to cigarette smoke (three cigarettes/d, 5 d/wk) for 7 mo. Lung elastin content was significantly decreased in C57BL/6J and DBA/2 but not in ICR mice. Also, emphysema, assessed morphometrically using three methods, was present in C57BL/6J and DBA/2 but not in ICR mice. In an additional study pallid mice, with a severe serum alpha(1)-proteinase inhibitor (alpha(1)-PI) deficiency and that develop spontaneous emphysema, were exposed to cigarette smoke for 4 mo. This resulted in an acceleration of the development of the spontaneous emphysema assessed with morphometrical and biochemical (lung elastin content) methods. All these results indicate that sensitivity to the effects of cigarette smoke is strain-dependent and cigarette smoke accelerates the effects of alpha(1)-PI deficiency.
Co-existent Parathyroid Adenoma and Thyroid Carcinoma
Authors: CHARLES INTENZO, CHAN H. PARK
Journal: Clinical Nuclear Medicine (1985)

Dual tracer parathyroid imaging (DTPI) using Tc-99m and TI-201 has a reported sensitivity of 92% for the detection of parathyroid adenomas. A patient with biopsyproven parathyroid adenoma as well as papillary thyroid carcinoma is presented. To date, this is the first such case ever to be reported and implies that DTPI, although a sensitive diagnostic modality for parathyroid adenoma detection, is not specific. The diagnosis of primary hyperparathyroidism has recently been established more frequently than in the past due to detection of elevated serum calcium levels on routine blood samples, relatively sensitive parathormone (PTH) assays, and noninvasive imaging modalities such as nuclear medicine, CT scanning, and ultrasonography. At our institution, we have successfully detected the location of parathyroid adenomas in many cases, using the dual tracer method with TI-201 and Tc-99m, confirmed at surgery. We present a case of primary hyperparathyroidism in which two distinct lesions were detected by nuclear imaging: one lesion was proven at surgery to be a parathyroid adenoma, while the other represented thyroid carcinoma.
Abstract LB-367: Wnt-dependent transcription factor LEF-1 controls endothelial cell invasion through changes of MMP-2 expression
Authors: Kestutis Planutis, Marina Planutiene, Randall F. Holcombe
Journal: Cancer Research (2010)

Abstract Background: Wnt signaling is involved in many events including embryogenesis, stem cell regulation, morphogenesis, cell fate determination, and oncogenesis. The role of Wnt pathway in angiogenesis is proposed, however the mechanism is still unclear. Most cancers express elevated levels of different Wnts when compared to normal cells. LEF-1 is a participant in and a target gene of the Wnt/ -catenin pathway. LEF-1 increases the in vitro invasiveness of cancer cells. Hypothesis: We suggest that LEF-1 controls the invasion also in endothelial cells. We hypothesize further that cancer affects local tumor angiogenesis via Wnt pathway-dependent up-regulation of LEF-1 in endothelial cells (EC). Methods: To test this hypothesis we construct a model system: endothelial cell line EaHy926 treated with Wnt3a (mostly known as a canonical Wnt signal) conditioned medium or grown in co-culture with L-cells producing Wnt3a. Results: Wnt3a increases nuclear ß-catenin in human endothelial cell line, and up-regulates LEF/TCF-dependent promoter activity. Wnt3a augments its target gene's LEF-1 promoter activity and LEF-1 mRNA concentration, demonstrating involvement of some transcription factors with E-tails. Both Wnt3a treatment and LEF-1 overexpression elevate MMP-2 mRNA level. Elimination of Wnt-dependent induction of MMP-2 gene expression by LEF-1 siRNA confirms the LEF-1 role in the MMP-2 control mechanism. Loosening up the extracellular matrix MMPs allows the cells to move around. These enzymes are integral part of invasion process. Indeed, LEF-1 up-regulates endothelial cells invasiveness in Matrigel matrix. LEF-1 increases also EC proliferation, in agreement with published data for parental primary endothelial culture HUVEC. Conclusions: In endothelial cells canonical (ß-catenin) Wnt signaling enhances invasiveness of EC via LEF-1 - dependent regulation of MMP-2 expression. There is a number of similarities between primary cells HUVEC, studied by others, and cell line EAhy926 in their response to Wnt3a. This indicates that EAhy926 cell line conserves many components of angiogenesis control by Wnt/β-catenin pathway and could serve as a simplified model to study this regulation, replacing primary endothelial cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-367.
Advantages of Blood Pooling in Pediatric MR Angiography⁎⁎Editorials published in JACC: Cardiovascular Imaging reflect the views of the authors and do not necessarily represent the views of JACC: Cardiovascular Imaging or the American College of Cardiology.
Authors: Martin R. Prince, Gregory D.N. Pearson, Hong Lei Zhang, Wyman W. Lai
Journal: JACC. Cardiovascular imaging (2010)
Alpha-fetoprotein synthesis by murine lymphoid cells in allogeneic reactions.
Authors: R H Keller, T B Tomasi
Journal: The Journal of Experimental Medicine (1976)

Surface-bound alpha-fetoprotein (AFP) was demonstrated by immunofluorescence on approximately 1/3 of splenic lymphocytes in chronic murine graft vs. host (GVH) reactions. Splenic lymphocytes were also shown to have a suppressed phytohemagglutinin (PHA) response compared to controls while lymph node cells from the same GVH animals revealed no surface AFP and had normal PHA responses. Splenic lymphocytes showed marked synthesis of AFP in the GVH and mixed lymphocyte culture (MLC) reactions by [14C]leucine incorporation and by radioimmunoassay in MLC supernates. Lymph node cells, however, demonstrated less synthetic activity and 14C counts in their membrane fractions were not markedly elevated.
&lt;EMPH TYPE="BOLD"&gt;Hepatitis B Vaccination Among Children in Inner-City Public Housing, 1991-1997&lt;/EMPH&gt;
Authors: Diane S. Lauderdale
Journal: JAMA (1999)

In 1991, the Advisory Committee on Immunization Practices recommended universal vaccination of infants against hepatitis B virus (HBV), with series initiation within days of birth.To determine HBV vaccine coverage in a low-income urban population and to examine whether HBV immunization within the first month of life affects subsequent vaccine receipt.Cohort study based on immunization records collected in the Pediatric Immunization Program. Setting Large public housing development in Chicago, Ill.All 1143 children who were born between 1991 and 1997 and enrolled between 1993 and mid-1998, with follow-up to age 35 months.On-time vaccine receipt of HBV vaccine doses, diphtheria-tetanus-pertussis vaccine (DTP) dose 1, and the 4:3:1 series (4 doses of DTP vaccine, 3 doses of poliomyelitis vaccine, and 1 dose of measles-containing vaccine), analyzed by year.On-time HBV vaccination increased quickly following new guidelines and reached a plateau of about 50% coverage for those born in or after 1995. Since 1994, more children (64%) received the first HBV vaccine dose on time than any other vaccine. Children who received a dose of HBV vaccine during their first month of life were more likely to receive the first DTP vaccine dose on time (60.1%) than those who did not get an HBV vaccine dose during the first month (36.4%; chi2 = 53.7; P<.001). Children who received the first HBV vaccine dose during their first month were more likely than those receiving it at age 1 to 2 months to complete 3 HBV doses by 19 months (70.6% vs 51.1%; chi2 = 11.6; P = .001) and to complete the 4:3:1 series by age 19 months (49.8% vs 37.9%; chi2 = 4.0; P = .05).In this inner-city population, HBV vaccine has been received at rates similar to those of other vaccines within 3 years of issuance of new recommendations. Of note, immunization with HBV vaccine at birth was associated with timely receipt of other vaccines and, therefore, may have the potential to increase vaccination among groups less likely to be up-to-date on early childhood vaccines.