tbuckley/cabot-search huggingface dataset:
A case of linear IgA disease occurring in a patient with colonic Crohn's disease
Authors: A.J. Birnie, W. Perkins
Journal: British Journal of Dermatology (2005)

Journal Article A case of linear IgA disease occurring in a patient with colonic Crohn's disease Get access A.J. Birnie, A.J. Birnie Queen's Medical Centre, Dermatology, Nottingham, U.K Dr Andrew Birnie. E‐mail: birnieandrew@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar W. Perkins W. Perkins Queen's Medical Centre, Dermatology, Nottingham, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 5, 1 November 2005, Pages 1050–1052, https://doi.org/10.1111/j.1365-2133.2005.06888.x Published: 01 November 2005 Article history Accepted: 15 December 2004 Published: 01 November 2005
Evolution of thoracic aorta atheroscielerosis in patients with heterozygous familial hypercholesterolemia after statin therapy
Authors: C.E. Pitsavos, J.D. Barbetseas, J.N. Sloumas, C.I. Aggeli, S.G. Lambrou, A.A. Frogoudaki, C.I. Stefanadis, P.K. Toutouzas
Journal: Journal of the American College of Cardiology (1998)
A Novel Two-Dimensional Echocardiographic Image Analysis System Using Artificial Intelligence-Learned Pattern Recognition for Rapid Automated Ejection Fraction
Authors: Maxime Cannesson, Masaki Tanabe, Matthew S. Suffoletto, Dennis M. McNamara, Shobhit Madan, Joan M. Lacomis, John Gorcsan
Journal: Journal of the American College of Cardiology (2006)
Association of blood lead to blood pressure in men aged 55 to 75 years: effect of selected social and biochemical confounders. NFR Study Group.
Authors: A Menditto, G Morisi, A Spagnolo, A Menotti
Journal: Environmental Health Perspectives (1994)

The association of blood lead (B-Pb) concentration to blood pressure was investigated in men aged 55 to 75 years living in the Rome area, who had no history of exposure to lead in the workplace and who participated between 1989 and 1990 in an epidemiologic survey for coronary heart disease (New Risk Factor Project). Of the 1856 individuals eligible for the study, 59 were excluded from analyses because not all relevant data were available; and 478 were excluded because they were treated for hypertension. In the remaining subjects (n = 1319) the median B-Pb concentration was 113 micrograms/l (range: 40-442 micrograms/l). Systolic blood pressure (SBP) averaged 140 +/- 18 (standard deviation) mm Hg (range 98-220) and diastolic blood pressure (DBP) 84 +/- 9 mm Hg (range 56-118). Median B-Pb values increased significantly from 111 micrograms/l in subjects with normal blood pressure (n = 668) to 113.5 micrograms/l in subjects with borderline high blood pressure (n = 373) and to 120 micrograms/l in subjects with increased blood pressure (n = 278). After log-normal conversion of B-Pb, the linear correlation coefficient between In[B-Pb(ug/l)] and both SBP and DBP was statistically significant (r = 0.1332, p &lt; 0.001 and r = 0.0737, p = 0.007, respectively). The linear regression coefficient was 6.8 mm Hg/In(micrograms/l) for SBP and 1.8 mm Hg/In(microgram/l) for DBP. Multiple regression analyses revealed that, after correction for body mass index (BMI), age, heart rate, skinfold thickness, serum lipids, and glucose levels; blood lead was still a significant predictor of increased SBP and DBP.(ABSTRACT TRUNCATED AT 250 WORDS)
Unusual cause of atrial fibrillation.
Authors: J M Reid, J F Kennedy, J McArthur
Journal: BMJ (1982)

Unusual cause of atrial fibrillationAtrial fibrillation is one of the most common arrhythmias and is caused most often by mitral stenosis, ischaemic heart disease, or thyrotoxicosis.It may also occur as a transient manifestation in the Wolff-Parkinson-White syndrome.More rarely there may be no detectable underlying lesion.We describe a patient who developed atrial fibrillation during the course of a chlamydia B infection, possibly due to complicating myocarditis. Case reportA 43-year-old man developed an influenza-like illness in November 1980 accompanied by a productive cough and wheeze but no chest pain.His wife and two children had similar illnesses at the time but of much shorter duration.Apart from a chronic duodenal ulcer, there was nothing relevant in his history, and in particular there was no previous cardiac trouble.Several weeks later he was noted to have developed atrial fibrillation, which led to his referral to hospital.On examination he was overweight (108-5 kg), but there were no signs of on 16 August 2023 by guest.
Painless Hematuria and Its Cause
Authors: H. B. Eisenstadt
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The Journalcontains a report by Dr. Mason G. Robertson (219:1213, 1972) of a patient with thalassemia minor having painless hematuria. I recently had the opportunity to examine a similar case. A 56-year-old black woman had been suffering from painless hematuria of three years' duration. She had been seen by several physicians including three urologists. She received a thorough general clinical examination which included tests for various bleeding factors with negative results. Intravenous and retrograde pyelograms, femoral arteriogram, and a generous open renal biopsy failed to show any abnormalities. Cystoscopic examination revealed bilateral renal hematuria. This patient's hemoglobin electrophoresis showed a slight amount of hemoglobin A-2 and a greater portion of hemoglobin F, ie, the so-called high F gene of thalassemia (Wintrobe M:<i>Clinical Hematology</i>, ed 6. Philadelphia, Lea &amp; Febiger, 1967, p 724). There was no sickling and no hemoglobin S was present. This patient's hematuria
Studies of diabetic instability. II. Tests of insulinogenic reserve with infusions of arginine, glucagon, epinephrine, and saline
Authors: Guillermo M. Cremer, George D. Molnar, William F. Taylor, Karen E. Moxness, F.John Service, Laël C. Gatewood, Eugene Ackerman, John W. Rosevear
Journal: Metabolism (1971)
Commissioning chief predicts end of traditional doctors' contracts
Authors: R. Finch
Journal: BMJ (2008)

Implementing commissioning policies to their fullest extent could introduce an era of integrated care organisations in England, spelling the end of traditional GP and consultant contracts, a debate heard this week.

Speakers at the debate, organised by the think tank Civitas, also warned consultants of a looming threat to their future employment because NHS foundation trusts will be looking to cut “unprofitable” services.

The debate—called “Commission impossible: is ‘world class’ commissioning achievable in the NHS?”—focused on the world class commissioning strategy published by the Department of Health last year, which set out the minimum standards that primary care trusts …
A Physician's View of College Sex
Authors: Robert J. Collins
Journal: JAMA (1975)

SHE LOOKED like every other co-ed— long, straight hair, a sweatshirt too big, and dungarees too small. And her story was a familiar one. Her friends teased her about being a virgin so she had tried "it." Now, tearful and fearful, she described her symptoms. Examination showed only body lice— easily curable. Her reaction spoke volumes: "It sure wasn't worth it—it was no fun at the time, I've been worried ever since—and all it did was give me a dose of crabs." Ten years of listening to young women at a large Eastern university have made me aware of the sexual confusion of the children of a generation that either misunderstood or ignored sexuality and had little wisdom to pass on to its self-liberating children. Urged on by a loud minority, many young people have accepted a pattern of sexual activity that has no valid support. Anticipating love and happiness,
Inhibition of human erythropoietic colony formation in culture by treatment with Ia antisera.
Authors: R J Winchester, P A Meyers, H E Broxmeyer, C Y Wang, M A Moore, H G Kunkel
Journal: The Journal of Experimental Medicine (1978)

Incubation with Ia antiserum, followed by complement, markedly inhibited erythroid colonies arising from hematopoietic cells present in the nonadherent low density fractions of normal bone marrow. Both erythropoietin-dependent colonies and bursts were eliminated at dilutions of antiserum equivalent to, or greater than the dilutions required to abolish the granulocyte-macrophage colony formation. The inhibitory effect of the Ia antiserum was abolished by absorption with B but not T cells from lymphoid lines. Available evidence suggested that Ia determinants are expressed on the erythropoietin-sensitive progenitors of the erythroid series in precise analogy to their sequence of expression on the granulocyte lineage. In both lineages, as shown previously, the Ia determinants become undetectable during subsequent stages of differentiation.
Raised glucose concentrations and diabetes are associated with cancer risk
Authors: Susan Mayor
Journal: BMJ (2005)

High fasting serum glucose concentrations and diabetes are associated with increased risk of death from several cancers, according to a Korean follow up study of more than one million people ( JAMA 2005;293: 194-202).

The Korean cancer prevention study included all of the 829 770 men and 468 615 women aged 30 to 95 years receiving health insurance from the National Health Insurance Corporation who had had a health check every two years during 1992-5. Fasting serum glucose measurements were taken during these health checks. For the follow up study the researchers collected cancer mortality and cancer incidence data from the national cancer registry and hospital records. …
Abstract 2178: Rotating night shift work and cancer mortality in the nurses' health study
Authors: Fangyi Gu, Jiali Han, Sue Hankinson, Eva Schernhammer, Nurses' Health Study Group
Journal: Cancer Research (2014)

Abstract Rotating night-shift work is common in western societies, but epidemiological studies on shift work and cancer mortality are limited. In a prospective closed cohort of 74,914 registered US nurses, the Nurses' Health Study, we examined the impact of rotating night-shift work on total-cancer and cancer-specific mortality. Rotating night-shift work was defined as having worked at least 3 nights per month. Cox proportional hazards models adjusting for age, smoking, BMI, and other important confounders, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 22 years of follow-up, we documented 5,123 cancer deaths. Overall, we observed no association between rotating night-shift work and total-cancer mortality (HR15+years=1.07; 95% CI, 0.97-1.19; Ptrend=0.17). However, women with 15 or more years of night-shift work had a significant increase in lung cancer mortality (multivariable HR=1.25; 95% CI, 1.04-1.50) and a borderline significant increase in colorectal cancer mortality (MV HR=1.32; 95% CI, 0.97-1.81). The increase in lung cancer mortality was limited to current smokers. We observed no increase in breast cancer mortality (HR15+years=1.03; 95%CI, 0.76-1.38; Ptrend=0.97). For cancers with fewer than 200 deaths, we observed a non-significant increase in mortality from kidney cancer, myeloma and leukemia among women with 6-14 and 15+ years of rotating night-shift work: the HRs were 1.58 (95% CI, 0.92-2.71) and 1.36 (95% CI, 0.72-2.56) for kidney cancer, 1.66 (95% CI, 0.98-2.81) and 1.47 (95% CI, 0.79-2.77) for myeloma, 1.25 (95% CI, 0.70-2.23) and 1.53 (95% CI, 0.83-2.83) for leukemia, respectively. We conclude that after adjusting for important confounders, the impact of rotating night-shift work on cancer mortality appears modest. Women working rotating night-shifts for more than 15 years had modestly increased colorectal and lung cancer mortality but the increase in lung cancer mortality was largely limited to current smokers and it is possible that these observations remain residually confounded by smoking. Additional studies are warranted to confirm our findings. Citation Format: Fangyi Gu, Jiali Han, Sue Hankinson, Eva Schernhammer, Nurses' Health Study Group. Rotating night shift work and cancer mortality in the nurses' health study. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2178. doi:10.1158/1538-7445.AM2014-2178
Results of systemic-to-pulmonary artery anastomosis for tricuspid atresia with reduced pulmonary blood flow.
Authors: G Crupi, O Alfieri, G Locatelli, M Villani, L Parenzan
Journal: Thorax (1979)

Fifty-six patients with tricuspid atresia and decreased pulmonary blood flow received a systemic-to-pulmonary artery anastomosis as a preliminary operation. Thirty-five had a Waterston shunt, 12 a Blalock-Taussig anastomosis, and nine various other procedures. The age at operation ranged from 2 days to 10 years (median 4.5 months). Pulmonary atresia was present in eight newborn infants. Four patients (7%), all less than 3 months old, died in hospital from persistent servere hypoxia despite the palliative procedure. By actuarial methods, 93% of the survivors were alive at and after one year (longest follow-up:9.8 years), while 83% had not required further palliation at and after four years from the first operation. None of the patients subsequently restudied had raised pulmonary pressure or resistances, and in most of them the pulmonary arterial tree was deemed adequate for the Fontan operation.
Heart attack, stroke, diabetes, and hypertension in West Indians, Asians, and whites in Birmingham, England.
Authors: J K Cruickshank, D G Beevers, V L Osbourne, R A Haynes, J C Corlett, S Selby
Journal: BMJ (1980)

Heart attack, stroke, diabetes, and hypertension in West Indians, Asians, and whites in Birmingham, England Hypertension is more common in black Americans than whites and is also common in Jamaica.1 2 In Jamaica heart attacks are infrequent, and mortality in blacks in Britain may also be lower.3The prevalence and complications of hypertension among West Indians in Britain have not yet been systematically examined.After observing that heart attacks seemed unduly uncommon in this group we examined admissions to Dudley Road Hospital over five years and compared rates for heart attack, stroke, hypertension, and diabetes among the three main ethnic groups.Number ( %) of admissions for all causes (excluding obstetrics and gynaecology) compared with heart attack, stroke, diabetes, and hypertension among ethnic groups aged 30 to 59 years during 1974 to 1978 inclusive Place of birth Reason for Total admission Europe and UK West Indies India, Pakistan, Other/not known
WHAT IS THE BEST PCI STRATEGY WITH SIROLIMUS-ELUTING STENT IN UNPROTECTED LEFT MAIN CORONARY ARTERIES?
Authors: Kensuke Takagi, Ken Kujiraoka, Jun Tanno, Yusuke Fujino, Miwako Tsukiji, Naoyuki Kurita, Jin Yokoyama, Sunao Nakamura
Journal: Journal of the American College of Cardiology (2010)
Subxiphoid Surgical Approach for Epicardial Catheter-Based Mapping and Ablation in Patients With Prior Cardiac Surgery or Difficult Pericardial Access
Authors: Kyoko Soejima, Gregory Couper, Joshua M. Cooper, John L. Sapp, Laurence M. Epstein, William G. Stevenson
Journal: Circulation (2004)

Percutaneous epicardial mapping and ablation are successful in some patients with ventricular epicardial reentry circuits but may be impossible when pericardial adhesions are present, such as from prior cardiac surgery. The purpose of this study was to evaluate the feasibility of direct surgical exposure of the pericardial space to allow catheter epicardial mapping and ablation in the electrophysiology laboratory when percutaneous access is not feasible.In 6 patients with prior cardiac surgery or failed percutaneous pericardial access, a subxiphoid pericardial window was attempted. In all 6 patients, manual lysis of adhesions exposed the epicardial surface of the heart through a small subxiphoid incision and allowed placement of an 8F sheath into the pericardial space under direct vision. Access to the diaphragmatic surface of the heart with ablation catheters was achieved in all patients, and catheter manipulation to the lateral and anterior walls was possible in 4 patients. Three-dimensional electroanatomic voltage maps revealed low-amplitude regions in the inferior or posterior left ventricular epicardium. A total of 16 ventricular tachycardias were induced, and 14 were abolished by radiofrequency ablation. Ablation was limited by intrapericardial defibrillator patches adherent to the likely target region in 2 patients. All patients had chest pain consistent with pericarditis early after the procedure that resolved within a few days. There were no other complications.A direct surgical subxiphoid epicardial approach in the electrophysiology laboratory is feasible for patients with difficult pericardial access who require ablation of epicardial arrhythmia foci.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) as a potent and persistent thyroxine agonist: a mechanistic model for toxicity based on molecular reactivity.
Authors: J D McKinney, J Fawkes, S Jordan, K Chae, S Oatley, R E Coleman, W Briner
Journal: Environmental Health Perspectives (1985)

TCDD and thyroxine have common molecular reactivity properties which enable them to present a planar face and lateral halogens in interactions with proteins. These molecular properties are consistent with the structure-toxicity relationship for TCDD and related compounds. Biological evidence is discussed including preliminary studies on the effects of TCDD exposure on tadpole growth and development which is consistent with the possible thyroxine-like activity of TCDD. The work suggests the possibility that toxicity is at least in part the expression of potent and persistent thyroid hormone activity (responses induced by TCDD which qualitatively correspond to those mediated by thyroid hormones). A mechanism for toxicity is proposed which involves receptor proteins; the planar aromatic system controls binding to cytosolic proteins and halogen substituents regulate binding to nuclear proteins. This simple model based on molecular reactivity sheds light on the diversified effects of TCDD and related compound toxicity and on certain thyroid hormone action. The model also permits predictions to be made with regard to the toxicity and thyroid hormone activity of untested compounds. In addition, the model suggests a general mechanism for hormone action based on metabolically regulated differential and cooperative protein receptor binding events in cellular compartments which can explain agonism, antagonism and potentiation within the framework of receptor occupancy theory.
Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Ignacio Pérez de Castro, Cristina Aguirre-Portolés, Gonzalo Fernández-Miranda, Marta Cañamero, Dale O. Cowley, Terry Van Dyke, Marcos Malumbres
Journal: Cancer Research (2013)

Aurora-A is a kinase involved in the formation and maturation of the mitotic spindle and chromosome segregation. This kinase is frequently overexpressed in human cancer, and its activity may confer resistance to antitumoral drugs such as Taxol. Inhibition of Aurora-A results in mitotic defects, and this kinase is considered as an attractive therapeutic target for cancer. Nevertheless, the specific requirements for this kinase in adult mammalian tissues remain unclear. Conditional genetic ablation of Aurora-A in adult tissues results in polyploid cells that display a DNA-damage-like response characterized by the upregulation of p53 and the cell-cycle inhibitor p21(Cip1). This is accompanied by apoptotic, differentiation, or senescence markers in a tissue-specific manner. Therapeutic elimination of Aurora-A prevents the progression of skin and mammary gland tumors. However, this is not due to significant levels of apoptosis or senescence, but because Aurora-A-deficient tumors accumulate polyploid cells with limited proliferative potential. Thus, Aurora-A is required for tumor formation in vivo, and the differential response observed in various tissues might have relevant implications in current therapeutic strategies aimed at inhibiting this kinase in the treatment of human cancer.
Medical Students From Natural Science and Nonscience Undergraduate Backgrounds
Authors: Robert L. Dickman
Journal: JAMA (1980)

The majority of matriculating US medical students continue to major in the natural sciences as college undergraduates in the belief that this will enhance their chances of admission to and their performance in medical school. The present study compared the academic performance and residency selection of natural science and nonscience majors in three separate medical school classes at the State University of New York at Buffalo. Statistical analysis of grades in the first two years of medical school, clinical performance in the third year, and part I and part II National Board Medical Examination scores revealed no significant differences across three class replications. Residency selection among graduating seniors was also independent of undergraduate major. It is suggested that admissions committees, premedical advisors, and students reconsider their attitudes about the necessity of concentration in the natural sciences before entering medical school.
Influence of cimetidine on pharmacokinetics of propranolol.
Authors: J H Bauman
Journal: BMJ (1981)

We would certainly support your view, and so would our patients, that adrenaline is the most effective drug to use and ought to be given first.It is surprising, therefore, to see no mention of adrenaline in the sections of the new British National Formulary on the treatment of severe allergic reactions to insect venom and of anaphylaxis from other causes.While the alternative advice to give intravenous hydrocortisone may be life saving in status asthmaticus-and we are in no way arguing against its use we believe that the failure to administer adrenaline in anaphylactic shock is dangerous.
Intraperitoneal ivalon mimicking peritoneal malignancy after plugged percutaneous liver biopsy
Authors: N P Thompson, P J Scheuer, R Dick, G Hamilton, A K Burroughs
Journal: Gut (1993)

Abstract Intraperitoneal ivalon mimicking peritoneal malignancy after plugged percutaneous liver biopsy is reported in a 20 year old woman with a history of nausea and abdominal distension.
Intravascular Coagulation in Acute Renal Failure After Myocardial Infarction
Authors: HENRYK KRUG
Journal: Annals of Internal Medicine (1974)

Serial coagulation studies were performed on three patients with acute renal failure caused by cardiogenic shock. During sustained oliguria, despite improvement of hemodynamic conditions, an excessive rise in serum fibrin degradation product (FDP) concentrations concomitant with a decrease in the platelet count was shown, whereas the fibrinogen level and fibrinolytic activity remained within normal limits. After heparin treatment, a prompt improvement in urine output and renal function was seen, together with a sharp decrease in serum FDP. In two patients a significant rise in the platelet count was noted. These findings suggest that some cases of ischemic acute renal failure may be an example of localized intravascular coagulation. Two patients survived, one without clinical evidence of renal disease, and the second is hypertensive with impaired kidney function. The only fatality occurred after initial improvement and can be directly ascribed to severe myocardial reinfarction.