tbuckley/cabot-search huggingface dataset:
Leftward septal displacement during right ventricular loading in man.
Authors: J A Brinker, J L Weiss, D L Lappé, J L Rabson, W R Summer, S Permutt, M L Weisfeldt
Journal: Circulation (1980)

Little direct evidence in man indicates that acute right ventricular loading alters left ventricular configuration.We used the Mueller maneuver (forced inspiration against a closed airway) to increase right ventricular loading and evaluated septal shape and right and left ventricular size in nine normal, semisupine men with phased-array, two-dimensional echocardiography.End-systolic and end-diastolic frames in cross-sectional and longitudinal views of the ventricles were recorded at rest and at various phases during the Mueller period (peak inspiratory effort of 40-60 mm Hg negative pressure).Acute leftward displacement of the septum at end-diastole on cross section during the maximal early Mueller period (first two or three beats after the onset of Mueller maneuver) was evidenced by a substantial increase in the radius of curvature of the septal segment (3.72 ± 0.25 cm vs control, 2.49 ± 0.12 cm,p < 0.001).This leftward septal displacement per- sisted not only during end-diastole, but also during end-systole (3.58 ± 0.45 vs 2.04 ± 0.16 cm;p < 0.01).The septal radius of curvature did not differ from the radius of curvature of the remainder of the left ventricle at rest for systole or diastole (1.94 ± 0.11 and 2.48 ± 0.09 cm, respectively), but differed markedly during the early Mueller phase in both systole (3.58 + 0.45 vs 1.9 ± 0.07 cm; p < 0.005) and diastole (3.72 ± 0.25 vs 2.36 ± 0.07 cm; p < 0.001).Simultaneously, left ventricular end-diastolic cavity areas decreased from control to the early Mueller phase on cross-sectional view from 19.14 ± 1.08 cm2 to 15.73 ± 0.65 cm2 (p < 0.005), and longitudinal view from 29.83 ± 2.08 to 20.74 1.46 cm2; p < 0.001.A significant decrease in end- systolic cavity area was also noted in this view (19.72 i 2.0 to 15.23 ± 1.98 cm2;p < 0.05).Right ventricular end-diastolic diameter increased from control to the early Mueller phase in the cross-sectional view (1.06 ± 0.14 to 1.31 ± 0.17 cm;p < 0.02), as well as in the longitudinal view (1.14 ± 0.23 to 1.80 ± 0.43 cm; p < 0.05).A decrease in left ventricular volume with maintenance of constant shape should result in a shortened radius of curvature for all portions of the ventricle, so the increase in septal radius of curvature in the face of an overall decrease in left ventricular size indicates that right ventricular loading alters left ventricular shape by flattening the septum.This septal flattening persists during systole.Thus, changed septal shape may be an important mechanism of, and evidence for, ventricular interdependence in normal man.
MAGNIFICATION OF SPERMATOZOA BY ELECTRON MICROSCOPE
Authors: Frances Seymour
Journal: JAMA (1941)

<h3>To the Editor:—</h3> In order to set at rest the minds of any other readers who may have seen our preliminary report of "Magnification of Spermatozoa by Means of the Electron Microscope" inThe Journal, May 31, we would refer to certain points in a communication recently appearing in one of the issues ofThe Journalmaking reference to this article. The essential things pointed out in the preliminary report are that the structures described were viewed under a magnification of twenty-seven thousand diameters and can therefore not be compared with the microscopic anatomy formerly recognized at two or three thousand diameters by the use of an oil immersion lens. Furthermore, the sperm described in the article appeared to be "pear shaped" and the irregularity at the vertex of the head seemed to suggest the possibility of the presence there of a "distinct organ." Future studies with the same or
Pericarditis: A Probably Overlooked Complication of Endoscopic Variceal Sclerotherapy
Authors: G. C. Caletti, E. Brocchi, E. Labriola, G. Gasbarrini, L. Barbara
Journal: Endoscopy (1990)

Two cases of acute pericarditis following endoscopic variceal sclerotherapy (EVS) that were resolved with conservative management are described. This complication arose respectively one and three days after EVS. The possible pathogenesis is the involvement of the pericardium in an inflammatory reaction that develops in the esophageal wall and surrounding tissues. Only five cases have been previously reported in the literature; the authors suppose that this fact may be due to the mild symptoms presented by the patients, which may result in underestimation of this complication. The technical details of EVS in the seven patients with pericarditis were analyzed, but no common etiologic factor was found. The authors strongly advise regular checks for clinical and instrumental signs of acute pericarditis after every session of EVS, so that appropriate management can be undertaken in an early phase and, if necessary, further EVS sessions delayed, in order to avoid cardiac tamponade or constrictive pericarditis.
Increased bone mineral density in a subset of patients with relapsed multiple myeloma who received the combination of bortezomib, dexamethasone and zoledronic acid
Authors: E. Terpos, D. Christoulas, P. Kokkoris, K. Anargyrou, M. Gavriatopoulou, M. Migkou, K. Tsionos, M.A. Dimopoulos
Journal: Annals of Oncology (2010)
Suspected Subdural Hematoma
Authors: Ozlem Ozkul-Wermester, Evelyne Guégan-Massardier, Aude Triquenot-Bagan, Olivier Langlois, Romain Lefaucheur, Bertrand Bourre
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue
Uptake of Tc-99m MDP in Shoulder Muscle Caused by the Use of Elbow Crutches
Authors: GUDRUN BERN, OTTE BROSJÖ, HANS JACOBSSON
Journal: Clinical Nuclear Medicine (1999)

An 18-year-old man underwent a routine bone scan 3 years after an operation for osteosarcoma of the right tibia. There was no sign of relapse. However, radioactive uptake (which was not observed 6 months previously) was detected in both teres minor muscles. Bone-seeking radiopharmaceuticals have been observed to accumulate in muscles after strenuous exercise. This uptake is believed to reflect rhabdomyolysis, and its location specifically reflects the type of exercise. In the case reported here, the patient had been using elbow crutches for 4 months before the scan because of stress fractures in the right tibia. We believe the muscular uptake was caused by the use of crutches.
The Problem With Peripherally Inserted Central Catheters
Authors: Vineet Chopra, Scott A. Flanders, Sanjay Saint
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atherosclerosis: Pathology, Physiology, Aetiology, Diagnosis and Clinical Management
Authors: Louts N. Katz
Journal: JAMA (1969)

This is an encyclopedic presentation of the pathology, physiology, etiology, diagnosis, and clinical management of atherosclerosis in its many forms. It is based on a previous German monograph edited by Schettler and now out of print. Boyd has joined Schettler as coeditor of the present text. The number of authors has been enlarged to include participants from Germany, Switzerland, Scotland, Hungary, and the United States. The book, profusely illustrated, runs to 1,029 pages. Regrettably in the English edition a number of clumsy sentences retain hints of their German origin. The quality of the illustrations in the section on arrhythmias is not up to the standard of the rest of the book. Furthermore, the subdivisions of the book could be improved. For example, chapter 6 is divided into nine sections, with section "g" a composite of two disparate parts, the first dealing with plasma lipids and lipoproteins from the biochemical viewpoint,
Tamoxifen Resistance in Breast Cancer
Authors: Lambert C.J. Dorssers, Silvia van der Flier, Arend Brinkman, Ton van Agthoven, Jos Veldscholte, Els M.J.J. Berns, Jan G.M. Klijn, Louk V.A.M. Beex, John A. Foekens
Journal: Drugs (2001)
Traitement du diverticule de Zenker par septotomie endoscopique
Authors: P Pouderoux
Journal: Endoscopy (2007)

Le traitement du diverticule de Zenker est endoscopique ou chirurgical. Le but du traitement endoscopique est de réaliser une incision de la paroi du septum musculaire séparant le diverticule de la lumière oesophagienne. Cette septotomie permet de faire communiquer plus largement le diverticule avec l'œsophage pour faciliter sa vidange. Le traitement endoluminal se fait habituellement par les chirurgiens ORL avec un tube rigide dédié: le diverticuloscope. Une alternative au tube rigide peut être l'endoscopie souple avec un vidéogastroscope. Cette technique est présentée dans le film.
The Osteopathy Bill.
Authors: Flavel K. Granger
Journal: JAMA (1897)

(COPY) Chicago, April 26, 1897. <h3>Dear Senator Granger:</h3> —I have looked over the Osteopathy Bill, as introduced by you, and do not know what arguments were brought to bear upon you to father it, but the Bill is one which will be very unjust to the medical profession in this State, if allowed to pass; besides, it would make the State the dumping ground for quacks. Personally, I would be very pleased to hear that you will quietly pocket the bill, or do something to stop its passage. I am faithfully yours, Illinois Senate, Springfield, Ill.
With the “Universal Definition,” Measurement of Creatine Kinase-Myocardial Band Rather Than Troponin Allows More Accurate Diagnosis of Periprocedural Necrosis and Infarction After Coronary Intervention
Authors: Chris C.S. Lim, William J. van Gaal, Luca Testa, Florim Cuculi, Jayanth R. Arnold, Theodoros Karamitsos, Jane M. Francis, Steffen E. Petersen, Janet E. Digby, Stephen Westaby, Charalambos Antoniades, Rajesh K. Kharbanda, Louise M. Burrell, Stefan Neubauer, Adrian P. Banning
Journal: Journal of the American College of Cardiology (2011)
NEURALGIA OF THE NECK OF THE BLADDER
Authors: C. W. Bell
Journal: BMJ (1856)

16Lth lgs.But I am now able to produce a very con- elusi cas at point.CAN Obed 0., aged 77, consulted me in September 1854, for a swelling of his right cheek, that had existed about four months Wore I saw him.The right malar re- gion was considerably swollen, felt doughy, was dingy red ad glossy; it was very tender, and he experienced re- mitting pains in the part, of a pricking and shooting cha- racter.He had five decayed teeth in front of the upper jaw, and had lost all his other teeth long before.The Tision of the right eye was unimpaired.In his right
Abstract 4431: A novel derivative of the Cdk inhibitor roscovitine that induces apoptosis in CLL and overcomes stromal cell-mediated protection
Authors: Rong Chen, Yuling Chen, Simon R. Green, William G. Wierda, William Plunkett
Journal: Cancer Research (2010)

Abstract Cmpd 5 is a derivative of R-roscovitine (CYC-202, seliciclib) with increased potency that selectively inhibits Cdk2, Cdk5 and Cdk9. In chronic lymphocytic leukemia (CLL) a disease that is addicted to the over-expression of anti-apoptotic proteins for survival, inhibition of Cdk9 by Cmpd 5 reduced phosphorylation of the C-terminal domain of RNA polymerase II and blocked transcription. These actions depleted the intrinsically short-lived anti-apoptotic protein Mcl-1, and induced apoptosis in CLL cells in vitro. Cmpd 5 was about 30 times more potent than its parent compound R-roscovitine with an IC50 of 0.86 µM after a 24-hr incubation. Although cell death was initiated after a 4-hr incubation in a time course study of Cmpd 5-induced apoptosis, the maximum cell death was not reached until 10-12 hr. In addition, it was known that co-culture of CLL cells with the marrow and lymphoid stromal cells may be responsible for resistance to fludarabine therapy. We evaluated Cmpd 5 in overcoming such stromal cell-mediated protection. Cmpd 5 killed the CLL cells similarly in the presence or absence of the human stromal cell line StromaNKtert without toxicity to the stromal cells, whereas the stromal cells clearly protected the CLL cells from the toxicity of fludarabine. Since Mcl-1 is the major target of Cmpd 5 in CLL, and the action of Cmpd 5 relies on the intrinsically rapid turn-over rate of Mcl-1, we compared the protein levels and the half-life of Mcl-1 in CLL cells in the presence or absence of the stromal cell layer. After an overnight incubation of CLL cells with the StromaNKtert cells, there was a 3-4 fold induction of Mcl-1 transcript and protein. However, there was no difference in the Cmpd 5-induced decay rate of either the Mcl-1 mRNA or protein, indicating that stromal cells did not alter the stability of Mcl-1. Therefore, the elevated Mcl-1 level likely indicated increased biosynthesis, rather than enhanced stability. Thus, the activation of the survival pathways and induction of the biosynthesis of Mcl-1 by the stromal cells may protect CLL cells from fludarabine-induced apoptosis but loss of the short-lived anti-apoptotic proteins was not affected, explaining the lack of stromal cell protection for CLL cells from Cmpd 5. Similar time-dependence of cell death induction as well as stromal cell response was also observed with other inhibitors of transcription including flavopiridol, R-roscovitine and Actinomycin D, implying a class effect. Taken together, our data suggested that Cmpd 5 is a promising candidate for clinical development for CLL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4431.
Therapeutic Evaluation of microRNAs by Molecular Imaging
Authors: Thillai V. Sekar, Ramkumar Kunga Mohanram, Kira Foygel, Ramasamy Paulmurugan
Journal: Theranostics (2013)

MicroRNAs (miRNAs) function as regulatory molecules of gene expression with multifaceted activities that exhibit direct or indirect oncogenic properties, which promote cell proliferation, differentiation, and the development of different types of cancers. Because of their extensive functional involvement in many cellular processes, under both normal and pathological conditions such as various cancers, this class of molecules holds particular interest for cancer research. MiRNAs possess the ability to act as tumor suppressors or oncogenes by regulating the expression of different apoptotic proteins, kinases, oncogenes, and other molecular mechanisms that can cause the onset of tumor development. In contrast to current cancer medicines, miRNA-based therapies function by subtle repression of gene expression on a large number of oncogenic factors, and therefore are anticipated to be highly efficacious. Given their unique mechanism of action, miRNAs are likely to yield a new class of targeted therapeutics for a variety of cancers. More than thousand miRNAs have been identified to date, and their molecular mechanisms and functions are well studied. Furthermore, they are established as compelling therapeutic targets in a variety of cellular complications. However, the notion of using them as therapeutic tool was proposed only recently, given that modern imaging methods are just beginning to be deployed for miRNA research. In this review, we present a summary of various molecular imaging methods, which are instrumental in revealing the therapeutic potential of miRNAs, especially in various cancers. Imaging methods have recently been developed for monitoring the expression levels of miRNAs and their target genes by fluorescence-, bioluminescence- and chemiluminescence-based imaging techniques. Mature miRNAs bind to the untranslated regions (UTRs) of the target mRNAs and regulate target genes expressions. This concept has been used for the development of fluorescent reporter-based imaging strategies to monitor the functional status of endogenous miRNAs, or the respective miRNAs transiently co-expressed in cells. Bioluminescence-based imaging strategies have been used to investigate various stages of miRNA processing and its involvement in different cellular processes. Similarly, chemiluminsecence methods were developed for in vitro miRNA imaging such as monitoring their therapeutic roles in various cancer cell lines.
Physiology of the Gastrointestinal Tract
Authors: Bertram Fleshler
Journal: JAMA (1969)

Of easily readable size and presenting its material in an attractive format, this work is oriented toward the medical student. It covers the subject under major headings of splanchnic circulation, motor mechanisms, secretion, digestion, and absorption. The bibliography is brief, and controversial points generally are passed over. Although opinions differ over what the medical student should be taught and how material should be presented, coverage certainly offers an adequate background in most areas of gastrointestinal physiology. Hepatic physiology, however, is incompletely examined, and the authors seem not to have decided how to approach this complicated subject. Perhaps hepatic physiology, now so extensive, can be covered adequately only in a separate volume. Some of the material is presented and discussed in a confusing or inadequate manner, especially for a book designed as an introductory text for students. For example, the authors mention results obtained by using a Pavlov pouch, but they
'Twas idiopathic unilateral circumscribed hyperhidrosis
Authors: N. H Cox
Journal: BMJ (2008)

Bronkhorst and Bouwman described a typical example of idiopathic unilateral circumscribed hyperhidrosis, an unusual form of this condition.1

They discuss palmar and plantar hyperhidrosis, and secondary forms of hyperhidrosis (usually generalised), but none of these …
IDENTIFICATION OF LEFT ATRIUM ACTIVE GANGLIONATED PLEXI BY DENSE EPICARDIAL MAPPING AS ABLATION TARGETS FOR THE TREATMENT OF ATRIAL FIBRILLATION
Authors: Yusuke Kondo, Marehiko Ueda, Michiko Watanabe, Masahiro Ishimura, Takatsugu Kajiyama, Naotaka Hashiguchi, Tomonori Kanaeda, Masahiro Nakano, Yasunori Hiranuma, Toru Ishizaka, Goro Matsumiya, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2013)
Interferon therapy reduces the risk for hepatocellular carcinoma
Authors: J L BROWN
Journal: Gut (2000)

ObjectTo examine the eVect of interferon on the risk of hepatitis C infected individuals developing hepatocellular carcinoma after adjusting for other risk factors including the degree of fibrosis. Methods Multicentre retrospective cohort study of 2890Japanese patients with hepatitis C, of whom 2400 received interferon and 490 did not.All cases had undergone liver biopsy within a year of commencement of treatment and minimum follow up was one year (including six monthly ultrasound examinations).Risk factors examined included age, degree of fibrosis, transaminase levels, viral load and genotype.Analysis was by intention to treat using Cox proportional hazards regression analysis.
Paclitaxel Modulates TGFβ Signaling in Scleroderma Skin Grafts in Immunodeficient Mice
Authors: Xialin Liu, Shoukang Zhu, Tao Wang, Laura Hummers, Fredrick M Wigley, Pascal J Goldschmidt-Clermont, Chunming Dong
Journal: PLoS Medicine (2005)

Background Systemic sclerosis (SSc) is characterized by excessive fibrosis and obliterative vascular lesions. Abnormal TGFβ activation is implicated in the pathogenesis of SSc. Aberrant TGFβ/Smad signaling can be controlled by stabilization of microtubules with paclitaxel. Methods and Findings SSc and healthy human skin biopsies were incubated in the presence or absence of paclitaxel followed by transplantation into severe combined immunodeficient mice. TGFβ signaling, fibrosis, and neovessel formation were evaluated by quantitative RT-PCR and immunohistochemical staining. Paclitaxel markedly suppressed Smad2 and Smad3 phosphorylation and collagen deposition in SSc grafts. As a result, the autonomous maintenance/reconstitution of the SSc phenotype was prevented. Remarkably, SSc grafts showed a 2-fold increase in neovessel formation relative to normal grafts, regardless of paclitaxel treatment. Angiogenesis in SSc grafts was associated with a substantial increase in mouse PECAM-1 expression, indicating the mouse origin of the neovascular cells. Conclusion Low-dose paclitaxel can significantly suppress TGFβ/Smad activity and lessen fibrosis in SCID mice. Transplantation of SSc skin into SCID mice elicits a strong angiogenesis—an effect not affected by paclitaxel. Although prolonged chemotherapy with paclitaxel at higher doses is associated with pro-fibrotic and anti-angiogenic changes, the findings described here indicate that low-dose paclitaxel may have therapeutic benefits for SSc via modulating TGFβ signaling.
Revitalising rapid responses
Authors: Sharon Davies, Tony Delamothe
Journal: BMJ (2005)

We're raising the bar for publication 

> I will go root away 
> 
> The noisome weeds, which without profit suck 
> 
> The soil's fertility from wholesome flowers. 

Shakespeare, Richard II 

W hen we were somewhat greener, we likened websites to gardens: both combine amazing opportunities for experiment with the option of obliterating mistakes when things go wrong.1 But even then we warned, “Turn your back on them for a few weeks, and they're overrun with weeds.” This is the fate that has befallen rapid responses, and why we're raising our threshold for publication.

On their launch, these electronic letters to the editor were hailed as the salvation of the journal's need to provide opportunities for timely debate. Previously, we had published only about one third of the letters to the editor that we received, and those about six months late.2

Marking the publication of the 20 000th response in 2002, we judged the experiment a …
Thyrotoxicosis Complicated by Thrombocytopenic Purpura
Authors: W. G. D. Caldwell, M. Meikle
Journal: BMJ (1953)

Small heat shock proteins (sHSPs), a family of HSPs, are known to accumulate in the CNS, mainly in astrocytes, in several pathological conditions such as Alexander9s disease, Alzheimer9s disease, and Creutzfeldt-Jakob disease. sHSPs may act not only as molecular chaperones, protecting against various stress stimuli, but may also play a physiological role in regulating cell differentiation and proliferation. In the present study, we have demonstrated that transient focal ischemia in rats dramatically induced HSP27 but not α B-crystallin (αBC), both of which are members of sHSPs, in reactive astrocytes. In contrast, <i>in vitro</i>chemical ischemic stress induced both HSP27 and αBC in cultured glial cells to the same extent. Dibutyryl cAMP (dBcAMP) and isoproterenol, a β-adrenergic receptor (βAR) agonist, enhanced HSP27 expression but suppressed αBC, and changed the shape of the cells to a stellate form. dBcAMP and isoproterenol inhibited cell proliferation under normal conditions. An increase in βAR-like immunoreactivity was also observed in reactive astrocytes <i>in vivo</i>. These results, together with recent findings that βAR plays an important role in glial scar formation <i>in vivo</i>, raise the possibility that βAR activation modulates sHSP expression after focal ischemia and is involved in the transformation of astrocytes to their reactive form.