Smoking and Theophylline Dose Schedules
Authors: R.I. OGILVIE
Journal: Annals of Internal Medicine (1978)

Editorial Notes1 February 1978Smoking and Theophylline Dose SchedulesR.I. OGILVIE, M.D.R.I. OGILVIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-2-263_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTheophylline is eliminated almost entirely by biotransformation in the liver. It is not surprising that changes in liver function alter the disposition of theophylline: Patients with hepatic cirrhosis have a markedly reduced capacity to eliminate it (1). More subtle changes in liver function associated with alterations in dietary protein and carbohydrate (2) and smoking (3-5) have also been observed.The enzymes responsible for biotransformation of theophylline in the liver are not known but probably include cytochrome P-448, which can be induced by substances contained in cigarette smoke such as 3,4-benzypyrene and related polycyclic hydrocarbons. This is a different enzyme system...References1. PIAFSKYSITARRANGNOOGILVIE KDRR: Theophylline disposition in patients with hepatic cirrhosis. N Engl J Med 296:1495-1497, 1977 CrossrefMedlineGoogle Scholar2. KAPPASANDERSONCONNEYALVARES AKAA: Influence of dietary protein and carbohydrate on antipyrene and theophylline metabolism in man. Clin Pharmacol Ther 20:643-653, 1976 CrossrefMedlineGoogle Scholar3. JENNENAGASAWAMCHUGHMCDONALDWYSE JHRFE: Decreased theophylline half-life in cigarette smokers. Life Sci 17:195-198, 1975 CrossrefMedlineGoogle Scholar4. HUNTJUSKOYURCHAK SWA: Effect of smoking on theophylline disposition. Clin Pharmacol Ther 19:546-551, 1976 CrossrefMedlineGoogle Scholar5. POWELLTHERCELINVOZEKSANSOMRIEGELMAN JJSLS: The influence of cigarette smoking and sex on theophylline disposition. Am Rev Respir Dis 116:17-23, 1977 MedlineGoogle Scholar6. PIAFSKYSITAROGILVIE KDR: Effect of phenobarbital on the disposition of intravenous theophylline. Clin Pharmacol Ther 22:336-339, 1977 CrossrefMedlineGoogle Scholar7. PIAFSKYOGILVIE KR: Dosage of theophylline in bronchial asthma. N Engl J Med 292:1218-1222, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Clinical Pharmacology Montreal General Hospital Montreal Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byConcerning drug interactions with theophyllinePharmacologic Approaches to Obstructive Airway DiseaseValeur clinique de la concentration de théophylline dans les liquides biologiquesNon-linear elimination processes of theophyllineLimitierte Bildung der 1,3-Dimethyl-Harnsäure nach TheophyllingabeOral sustained-release aminophylline in medical inpatients: factors related to toxicity and plasma theophylline concentrations.The pharmacokinetics of theophylline 1 February 1978Volume 88, Issue 2Page: 263-264KeywordsCarbohydratesCirrhosisEnzymesHydrocarbonsLiverProteins Issue Published: 1 February 1978 PDF downloadLoading ...