Cholesterol Reduction: Safety, Other Concerns
Authors: LESLIE M. KLEVAY
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 September 1987Cholesterol Reduction: Safety, Other ConcernsLESLIE M. KLEVAY, S.D. Hyg.LESLIE M. KLEVAY, S.D. Hyg.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-421 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe editor: Taylor and colleagues (1) calculated the increase in life expectancy of men and women who modify their habits to lower serum cholesterol levels. Their estimates probably are correct if the assumptions on which they have based their model are correct. In this regard, however, Claude Bernard (2) has said the following: ". . . application of mathematical analysis to natural phenomena . . . may have its dangers if experimental verification is entirely rejected," and, "our deductions, even though very logical, are absolutely uncertain and can in no case dispense with experimental verification."Eight studies (3-10) with data...References1. TAYLOR W, PASS T, SHEPARD D, and KOMAROFF A. Cholesterol reduction and life expectancy: a model incorporating multiple risk factors. Ann Intern Med. 1987;106:605-14. LinkGoogle Scholar2. BERNARD C. An Introduction to the Study of Experimental Medicine. Translated by GREENE HC. New York: Macmillan Publishing Company; 1927:30. Special edition by the Classics of Medicine Library, Birmingham, Alabama, 1980. Google Scholar3. . Multiple Risk Factor Intervention Trial: risk factor changes and mortality results. JAMA. 1982;248:1465-77. CrossrefMedlineGoogle Scholar4. . The Lipid Research Clinics Coronary Primary Prevention Trial results: I. Reduction in incidence of coronary heart disease. JAMA. 1984;251:351-64. CrossrefMedlineGoogle Scholar5. DAYTON S, PEARCE M, HASHIMOTO S, DIXON W, and TOMIYASU U. A controlled clinical trial of a diet high in unsaturated fat. Circulation. 1969;39-40 (suppl 2):1-63. MedlineGoogle Scholar6. HJERMANN I, VELVE BYRE K, HOLME I, and LEREN P. Effect of diet and smoking intervention on the incidence of coronary heart disease. Lancet. 1981;2:1303-10. CrossrefMedlineGoogle Scholar7. LEREN P. The Oslo diet-heart study. Circulation. 1970;42:935-42. CrossrefMedlineGoogle Scholar8. MIETTINEN M, TURPEINEN O, KARVONEN M, ELOSUO R, and PAAVILAINEN E. Effect of cholesterol-lowering diet on mortality from coronary heart-disease and other causes. Lancet. 1972;2:835-8. CrossrefMedlineGoogle Scholar9. OLIVER M, HEADY J, MORRIS J, and COOPER J. A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Br Heart J. 1978;40:1069-118. CrossrefMedlineGoogle Scholar10. . Multifactorial trial in the prevention of coronary heart disease: III. Incidence and mortality results. Eur Heart J. 1983;4:141-7. MedlineGoogle Scholar1. TAYLOR W, PASS T, SHEPARD D, and KOMAROFF A: Cholesterol reduction and life expectancy: a model incorporating multiple risk factors. Ann Intern Med. 1987;106:605-14. LinkGoogle Scholar1. TAYLOR W, PASS T, SHEPARD D, and KOMAROFF A. Cholesterol reduction and life expectancy: a model incorporating multiple risk factors. Ann Intern Med. 1987;106:605-14. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LESLIE M. KLEVAY, S.D. Hyg. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCholesterol and cost-effectiveness. Implications for practice, policy, and research.Ischemic Heart Disease as Copper Deficiency 1 September 1987Volume 107, Issue 3Page: 421-422KeywordsCholesterolHabitsLife expectancySafety ePublished: 1 December 2008 Issue Published: 1 September 1987 PDF downloadLoading ...