tbuckley/cabot-search huggingface dataset:
Hypertrophic osteoarthropathy in adults with cystic fibrosis.
Authors: M A Matthay, R A Matthay, D M Mills, S Lakshminarayan, E Cotton
Journal: Thorax (1976)

Three adult patients with cystic fibrosis presented with arthralgia, and investigation for the usual causes of arthritis proved negative. Radiographs of long bones revealed periostitis and new bone fromation characteristic of hypertrophic osteoarthropathy. Symptomatic improvement occurred after analgesic and anti-inflammatory therapy. In patients with cystic fibrosis and bone or joint pain, the diagnosis of hypertrophic osteoarthropathy should be considered and long bone radiographs obtained.
A Two-Year Follow-Up Study of the Work Performance of Former Psychiatric Patients
Authors: NYLA J. COLE, BLAIR W. MCDONALD, C. H. HARDIN BRANCH
Journal: American Journal of Psychiatry (1968)

This study presents employers' evaluations, at two time intervals, of the work performance of 181 former psychiatric patients diagnosed as either schizophrenic or psychoneurotic. Compared with matched controls who had no history of psychiatric treatment, subjects in the schizophrenic subgroup earned lower work performance ratings and fewer promotions; psychoneurotic subjects, however, earned work ratings essentially comparable with ratings of their control group and were about equally likely to be promoted.
EG-05 * COMBINATION OF GENE COPY GAIN AND EPIGENETIC DEREGULATION ARE ASSOCIATED WITH THE ABERRANT EXPRESSION OF A STEM CELL RELATED HOX-SIGNATURE IN GLIOBLASTOMA
Authors: S. Kurscheid, P. Bady, D. Sciuscio, I. Samarzija, T. Shay, I. Vassallo, W. Van Criekinge, E. Domany, R. Stupp, M. Delorenzi, M. Hegi
Journal: Neuro-Oncology (2014)

We previously reported a stem cell related HOX gene signature associated with resistance to chemo-radiotherapy (TMZ/RT- > TMZ) in glioblastoma. However, underlying mechanisms triggering overexpression remain mostly elusive. Interestingly, HOX genes are neither involved in the developing brain, nor expressed in normal brain, suggestive of an acquired gene expression signature during gliomagenesis. HOXA genes are located on CHR 7 that displays trisomy in most glioblastoma which strongly impacts gene expression on this chromosome, modulated by local regulatory elements. Furthermore we observed more pronounced DNA methylation across the HOXA locus as compared to non-tumoral brain (Human methylation 450K BeadChip Illumina; 59 glioblastoma, 5 non-tumoral brain sampes). CpG probes annotated for HOX-signature genes, contributing most to the variability, served as input into the analysis of DNA methylation and expression to identify key regulatory regions. The structural similarity of the observed correlation matrices between DNA methylation and gene expression in our cohort and an independent data-set from TCGA (106 glioblastoma) was remarkable (RV-coefficient, 0.84; p-value < 0.0001). We identified a CpG located in the promoter region of the HOXA10 locus exerting the strongest mean negative correlation between methylation and expression of the whole HOX-signature. Applying this analysis the same CpG emerged in the external set. We then determined the contribution of both, gene copy aberration (CNA) and methylation at the selected probe to explain expression of the HOX-signature using a linear model. Statistically significant results suggested an additive effect between gene dosage and methylation at the key CpG identified. Similarly, such an additive effect was also observed in the external data-set. Taken together, we hypothesize that overexpression of the stem-cell related HOX signature is triggered by gain of trisomy 7 and escape from compensatory DNA methylation at positions controlling the effect of enhanced gene dose on expression.
Sterility Following Vasectomy
Authors: Lloyd Stockwell
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In the Questions and Answers section ofThe Journal(<b>177:</b>224 [July 22] 1961), there was a question concerning establishment of sterility following vasectomy answered by Dr. L. F. Greene, which needs clarification as it represents the usual, though not the complete, answer. The answer was, "Bilateral vasectomy is considered to be successful if examination of the semen, 1 or 2 months after operation, discloses azoospermia." This alludes to the commonly accepted fact that time alone is necessary to produce infertility following bilateral vasectomy. I believe it more accurate to advise the patient he is infertile only after his seminal vesicle is emptied by ejaculations. Contraceptives should be used until azoospermia is proved. In more than 25 years of urology, I have examined successive ejaculates in cooperative patients to azoospermia. The findings are that 95% show no sperm by the fourth to sixth ejaculate. An additional 5%
Impairment of Ventilatory Efficiency in Heart Failure
Authors: F. X. Kleber, G. Vietzke, K. D. Wernecke, U. Bauer, C. Opitz, R. Wensel, A. Sperfeld, S. Gläser
Journal: Circulation (2000)

Background —Impairment of ventilatory efficiency in congestive heart failure (CHF) correlates well with symptomatology and contributes importantly to dyspnea. Methods and Results —We investigated 142 CHF patients (mean NYHA class, 2.6; mean maximum oxygen consumption [V̇ o 2 max], 15.3 mL O 2 · kg −1 · min −1 ; mean left ventricular ejection fraction [LVEF], 27%). Patients were compared with 101 healthy control subjects. Cardiopulmonary exercise testing was performed, and ventilatory efficiency was defined as the slope of the linear relationship of V̇ co 2 and ventilation (VE). Results are presented in percent of age- and sex-adjusted mean values. Forty-four events (37 deaths and 7 instances of heart transplantation, cardiomyoplasty, or left ventricular assist device implantation) occurred. Among V̇ o 2 max, NYHA class, LVEF, total lung capacity, and age, the most powerful predictor of event-free survival was the VE versus V̇ co 2 slope; patients with a slope ≤130% of age- and sex-adjusted normal values had a significantly better 1-year event-free survival (88.3%) than patients with a slope &gt;130% (54.7%; P &lt;0.001). Conclusions —The VE versus V̇ co 2 slope is an excellent prognostic parameter. It is easier to obtain than parameters of maximal exercise capacity and is of higher prognostic importance than V̇ o 2 max.
Neurohumoral prediction of left‐ventricular morphologic response to β‐blockade with metoprolol in chronic left‐ventricular systolic heart failure
Authors: Bjoern A. Groenning, Jens C. Nilsson, Per R. Hildebrandt, Andreas Kjaer, Thomas Fritz‐Hansen, Henrik B.W. Larsson, Lars Sondergaard
Journal: European Journal of Heart Failure (2002)
Cyclophosphamide followed by fludarabine for untreated chronic lymphocytic leukemia: a phase II SWOG TRIAL 9706
Authors: M A Hussein, H Gundacker, D R Head, L Elias, K A Foon, D H Boldt, S M Dobin, S R Dakhil, G T Budd, F R Appelbaum
Journal: Leukemia (2005)
Antiatherothrombotic Properties of Statins
Authors: Robert S. Rosenson, Christine C. Tangney
Journal: JAMA (1998)

Clinical trials of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or statin therapy have demonstrated that baseline or treated lowdensity lipoprotein (LDL) cholesterol levels are only weakly associated with net coronary angiographic change or cardiovascular events.The beneficial effects of statins on clinical events may involve nonlipid mechanisms that modify endothelial function, inflammatory responses, plaque stability, and thrombus formation.Experimental animal models suggest that statins may foster stability through a reduction in macrophages and cholesterol ester content and an increase in volume of collagen and smooth muscle cells.The thrombotic sequelae caused by plaque disruption is mitigated by statins through inhibition of platelet aggregation and maintenance of a favorable balance between prothrombotic and fibrinolytic mechanisms.These nonlipid properties of statins may help to explain the early and significant cardiovascular event reduction reported in several clinical trials of statin therapy.
THE BALANCE OF COLLOID AND CRYSTALLOID IN CHOLERA, SHOCK, AND ALLIED CONDITIONS
Authors: B. Moore
Journal: BMJ (1919)

COLLOID AND CRYSTALLOIP.f-TmzRam.L~~~~~~~~~~~~~~~~~~~~~~~~~~~M uRn and his arm was secured to his side.He arrived in hospital about one and a half hours after the accident.Condition oh Admimsion.He was suffering from severe shock, and was very rest-, less.There was a large non-pulsatile swelling over the left clavicle, extending up into the neck.There was no pulse at the left wrist.He was markedly bloodless; the whole of the left side of the chest was dull, and respiration could scarcely be heard.He appeared to be moribund.Diagno8i8.Injury or destruction of the' subelavian vessels, with bleeding into the left pleural cavity.Treatment.
Granulocyte Colony-Stimulating Factor in Induction Treatment of Children With Non-Hodgkin's Lymphoma: A Randomized Study of the French Society of Pediatric Oncology
Authors: C. Patte
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To determine whether granulocyte colony-stimulating factor (G-CSF; lenograstim) decreases the incidence of febrile neutropenia after induction courses in treatment of childhood non-Hodgkin’s lymphoma (NHL). PATIENTS AND METHODS: Patients were randomized to receive (G-CSF+) or not receive (G-CSF−) prophylactic G-CSF, 5 μg/kg/d, from day 7 until an absolute neutrophil count ≥ 500/μL was sustained over 48 hours, after two consecutive induction courses of cyclophosphamide 1.5 or 3 g/m2, vincristine 2 mg/m2, prednisone 60 mg/m2/d × 5, doxorubicin 60 mg/m2, high-dose methotrexate 3 or 8 g/m2, and intrathecal injections (COPAD[M]) on protocols LMB89, LMT89, and HM91 of the French Society of Pediatric Oncology. RESULTS: One hundred forty-eight patients were assessable, 75 G-CSF+ and 73 G-CSF−. Although duration of neutropenia less than 500/μL was 3 days shorter in G-CSF+ patients (P = 10−4), incidence of febrile neutropenia (89% v 93% in the first course, 88% v 88% in the second course), durations of hos...
Aplastic Anaemia Complicating Miliary Tuberculosis
Authors: R. J. Kernohan
Journal: BMJ (1950)

intubation is necessary or desirable C10 facilitates the passage of a Magill intratracheal tube without producing complete abdominal relaxation, which is so often unnecessary in E.N.T., orthopaedic, and other classes of operation.It may be used in conjunction with D-tubocurarine chloride to produce short-term relaxation of the abdominal muscles when the peritoneum is being closed and it is undesirable to give another dose of D-tubocurarine chloride because of its long action and cumulative effect.Full respiratory excursions will then be established before the patient returns to the ward.Antagonist.-Pentamethonium iodide, or C5, is the antidote to CIO.Hewer et al. (1949) have reported its effects.It acts by producing a block of the autonomic ganglia, and would seem to be contraindicated in major surgery.It may produce a profound fall in blood pres- sure, and the patient may collapse in a very alarming manner.No opportunity has arisen and no attempt been made to use this substance here.
Private sector is losing interest in PFI projects
Authors: Adrian O'Dowd
Journal: BMJ (2005)

The British private sector's enthusiasm for involvement in NHS private finance initiative (PFI) schemes is waning, a survey shows.

In responses to the survey, NHS staff at trusts that have a PFI scheme say that the number of bids from the private sector has fallen dramatically over the past eight years.

Early findings from the survey, conducted by the Future Healthcare Network, a section of the NHS Confederation (which represents NHS organisations), indicate that the process of agreeing PFI schemes takes too long and needs to be updated to make it more effective.

The network surveyed and got responses …
Paracervical block with bupivacaine.
Authors: C. Ruoss, J. M. Beazley
Journal: BMJ (1968)

tary proteolytic enzymes.Each patient should ideally be assessed individually by measuring the optimum amount of protein they can manage to achieve positive nitrogen balance.Excessive protein in the large bowel may merely exacerbate the symptoms which the low-fat diet has been introduced to control.-Weare, etc.,
Electroencephalogram and retinal vessels in congenital cyanotic heart disease before and after surgery.
Authors: E M Kohner, E M Allen, K B Saunders, V M Emery, C Pallis
Journal: BMJ (1967)

Ulcerative Colitis-Chuttani et al. MEDBRITISH 207Forty-six cases of ulcerative colitis were studied in detail.By comparison with Western series, ulcerative colitis as seen in this region is a milder disease with fewer complications and with less severe changes on sigmoidoscopy and rectal biopsy.The disease remains limited to the rectum, sigmoid colon, and descending colon in the majority of cases.Owing to the high prevalence of specific infections of the colon there are difficulties associated with the diagnosis of ulcerative colitis, and these are discussed.We are thankful to the Director-Principal of Maulana Azad Medical College and associated hospitals for permission to publish this work.
How high does intracellular sodium rise during acute myocardial ischaemia?
Authors: F. Verdonck
Journal: Cardiovascular Research (1995)

Journal Article How high does intracellular sodium rise during acute myocardial ischaemia? Get access Fons Verdonck Fons Verdonck Interdisciplinary Research Centre, Catholic University of Leuven Campus Kortrijk, B-8500 Kortrijk, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 2, February 1995, Page 278, https://doi.org/10.1016/S0008-6363(96)88583-X Published: 01 February 1995
A 39-Year-Old Woman with an Isolated Pancreatic Duct Stricture
Authors: J. H. Siegel, J. Baillie
Journal: Endoscopy (2001)

I am very pleased to welcome an old friend, Dr. Jerry Siegel of New York, as this month’s Guest Discussant. Dr. Siegel has been involved in gastrointestinal endoscopy in general, and endoscopic retrograde cholangiopancreatography (ERCP) in particular, since the early days; he is certainly one of the pioneers of modern gastrointestinal endoscopy. Welcome, Dr. Siegel!
Priorities in road accidents
Authors: J C Allen
Journal: BMJ (1979)

<b>Introduction:</b> Chronic thromboembolic pulmonary hypertension (CTEPH) can be tremendously improved or cured by pulmonary endarterectomy (PEA) or by balloon pulmonary angioplasty (BPA) or drug therapy. A multidisciplinary national videoconference CTEPH Board was introduced in 2018 under the umbrella of the Swiss Society of Pulmonary Hypertension as a platform of evaluation for surgery and treatment allocation for CTEPH patients.We aimed to report on the first 2 years activity of this national CTEPH board. <b>Material and Methods:</b> Since January 2018, a videoconference platform was installed to facilitate the case discussion among PH centers in Switzerland.Patients applications were submitted in advance and imaging uploaded, so that interdisciplinary discussion was feasible with full documentation available to every participants. <b>Results:</b> 95 patients were presented from 4 university- and 4 cantonal hospitals.Out of 95 patients reviewed by the national CTEPH board, diagnosis of CTEPH was confirmed in n=85, 25 of which underwent PEA (29%),another 15 are planned.PEA was performed in the Zurich University Hospital after a comprehensive outpatient evaluation 45 patients benefitted from BPA or medical therapy or needed further evaluations.A common and standardized follow-up after PEA has been implemented. <b>Conclusion:</b> The Swiss CTEPH national board builds a new platform for:1) diagnosis confirmation2) discussion of operability assessment between the referring physicians and the thoracic surgeons,3) evaluation of other therapeutic modalities in case of contra indication to PEA.Thus, this video-conference is providing access to modern and successful CTEPH treatments including PEA to a broad collective of patients.
Limited Exercise Capacity in Heterozygous Manganese Superoxide Dismutase Gene–Knockout Mice
Authors: Shintaro Kinugawa, Ziping Wang, Pawel M. Kaminski, Michael S. Wolin, John G. Edwards, Gabor Kaley, Thomas H. Hintze
Journal: Circulation (2005)

Background— We have reported that there is a limitation of exercise capacity in mice with defects in the expression of endothelial nitric oxide (NO) synthase, which is associated with a greater increase in whole-body oxygen consumption (V̇ o 2 ). We hypothesized that in states in which superoxide anion (O 2 − ) is increased, especially in the mitochondria, whole-body V̇ o 2 will be increased because of the inactivation of NO, and consequently, exercise capacity will be reduced. Methods and Results— Heterozygous manganese superoxide anion dismutase (SOD2) gene–knockout mice (SOD2 +/− ), in which SOD2 activity is reduced by 30% to 80%, and wild-type control mice (SOD2 +/+ ) were treadmill-tested to measure indices defining exercise capacity. Tempol was given to each mouse for 7 days by an intraperitoneal injection to scavenge O 2 − before a second treadmill testing. V̇ o 2 and carbon dioxide production (V̇ co 2 ) at rest were increased in SOD2 +/− . The work (vertical distance run × body weight) to exhaustion was decreased in SOD2 +/− . When the maximum V̇ o 2 and V̇ co 2 were corrected to per work unit, they were increased in SOD2 +/− . Tempol normalized basal V̇ o 2 and V̇ co 2 and improved the work to exhaustion and corrected V̇ o 2 and V̇ co 2 in SOD2 +/− . V̇ o 2 of skeletal muscle was measured in vitro. Bradykinin-induced reduction in V̇ o 2 in vitro was attenuated in SOD2 +/− , and was acutely restored by Tempol. There was a decrease in SOD2 protein level and a concomitant increase in lucigenin-detectable O 2 − production in skeletal muscle from SOD2 +/− . Conclusions— These results suggest that exercise capacity is reduced in conditions in which superoxide anion is increased, and this is associated with a greater increase in whole-body oxygen consumption in SOD2 +/− compared with SOD2 +/+ .
Blood alcohol limit in UK should be reduced, review says
Authors: M. Pownall
Journal: BMJ (2010)

<h3>Abstract</h3> We investigate the site frequency spectrum in the two-type model of clonal evolution. If the fitnesses of the two types are λ<sub>0</sub> &lt; λ<sub>1</sub> then the site frequency spectrum is <i>c</i>/<i>f<sup>α</sup></i> where <i>α</i> = λ<sub>0</sub>/λ<sub>1</sub>. This is due to the advantageous mutations that produce the founders of the type 1 population. Mutations within the growing type 0 and type 1 populations follow the 1/<i>f</i> law. Our results show that neutral evolution can be distinguished from the two-type model using the site frequency spectrum.
Outcomes of Men with Screen-Detected Prostate Cancer Eligible for Active Surveillance Who Were Managed Expectantly
Authors: Roderick C.N. van den Bergh, Stijn Roemeling, Monique J. Roobol, Gunnar Aus, Jonas Hugosson, Antti S. Rannikko, Teuvo L. Tammela, Chris H. Bangma, Fritz H. Schröder
Journal: European Urology (2008)
Pathophysiology of Chronic Left Ventricular Dysfunction
Authors: Norma V.S. Marinho, Bruce E. Keogh, Durval C. Costa, Adriaan A. Lammerstma, Peter J. Ell, Paolo G. Camici
Journal: Circulation (1996)

Background Chronically dysfunctional myocardium may improve after coronary revascularization. This condition was thought to be due to a chronically reduced myocardial blood flow (MBF). Recently, however, it has been shown that in patients without previous infarction but with chronic left ventricular dysfunction, baseline MBF was normal. Methods and Results To study the pathophysiology of chronic left ventricular dysfunction in patients with previous infarction, regional MBF (milliliter per minute per gram of water-perfusable tissue) and glucose utilization (MRG; micromoles per minute per gram) during hyperinsulinemic euglycemic clamp were measured with positron emission tomography in 30 patients before bypass. At baseline, 133 myocardial segments were normal, and 107 were dysfunctional. After revascularization, 59 of 107 segments improved, while 48 of 107 were unchanged. MBF was 0.92±0.25 mL · min −1 · g −1 in normal segments, 0.87±0.31 mL · min −1 · g −1 in improved segments ( P =NS versus normal), and 0.82±0.40 mL · min −1 · g −1 in unchanged segments ( P &lt;.05 versus normal). In 90% of the dysfunctional segments, MBF was &gt;0.42 mL · min −1 · g −1 , a cutoff value corresponding to the mean MBF minus 2 SD in normal segments. The MRG was 0.71±0.14 μmol · min −1 · g −1 in 9 age-matched normal subjects, 0.45±0.19 μmol · min −1 · g −1 ( P &lt;.01) in normal segments, 0.44±0.14 μmol · min −1 · g −1 in improved segments ( P =NS versus normal), and 0.34±0.17 μmol · min −1 · g −1 in unchanged segments ( P &lt;.01 versus normal and improved). Conclusions The results suggest that resting MBF measured with 15 O-labeled water in chronically dysfunctional segments is not reduced and that the myocardium of these patients is less sensitive to insulin than that of normal subjects.
Of Timing and Surrogates: A Way Forward for Cancer Chemoprevention
Authors: Patricia A. Thompson, Eugene W. Gerner
Journal: Clinical Cancer Research (2011)

Abstract Cancer chemoprevention strategies are not widely implemented in clinical practice. Targeting biomarkers in patients with elevated risk of developing cancer by means of short-term administration of certain agents may be a strategy to minimize toxicities while maintaining efficacy in clinical trials that can be completed in years rather than decades. Clin Cancer Res; 17(11); 3509–11. ©2011 AACR.
THE METHOD OF GIEMSA FOR STAINING THE SPIROCHÆTA PALLIDA.
Authors: LEONARD K. HIRSCHBERG
Journal: JAMA (1905)

Under the direction of Professor Charles F. Bevan, of the College of Physicians and Surgeons, considerable study is being given to the<i>Spirochæta pallida</i>of Schaudinn and Hoffman. The results of these studies will shortly be published by Professor Bevan and myself. In this search we have been fortunate enough to find<i>Spirochæta pallida</i>in the urine of one patient, with active secondary manifestations. In the meanwhile, since there has as yet been no English or American publication of the stain which has proved so effective in elucidating these organisms, I do not think it out of place or premature to publish Dr. Giemsa's method, somewhat modified from his first description.<sup>1</sup> <h3>GIEMSA'S STAIN.</h3> Azur II—Eosin, 3.00 gms. Azur II.—0.8 gms. Glycerin (C. P.), 250 c.c. Methyl alcohol, 250 c.c. Fix by spreading the specimen very thinly over the cover-slip; dry it in the air. Harden it in absolute alcohol
Rifampin: Characteristics and Role in the Chemotherapy of Tuberculosis
Authors: ARTHUR VALL-SPINOSA
Journal: Annals of Internal Medicine (1971)

The available evidence shows that a new drug, rifampin, rivals isoniazid in effectiveness against infection with Mycobacterium tuberculosis. The toxicity of rifampin and the best way to use it have not yet been established. Pending the results of controlled trials now under way, rifampin should be reserved for retreatment chemotherapy and for cases where drug intolerance prevents the use of current standard regimens.
successful Treatment of Extremely Brittle, Insulin-dependent Diabetes with a Novel Subcutaneous Insulin Pump Regimen
Authors: David M Nathan
Journal: Diabetes Care (1982)

Brittle, insulin-dependent diabetic patients with extremely labile glucose control requiring frequent hospitalizations were treated with a continuous subcutaneous insulin infusion delivered with a programme ble pump. As reported by others, the patients did not improve with a regimen of preprandial boluses superimposed on a continuous single-rate infusion. However, they demonstrated dramatic clinical and metabolic improvement with a modified pump regimen that delivered a variable square-wave insulin infusion and avoided any boluses. These very difficult patients can benefit by insulin pump therapy.