Host Susceptibility and Acetaminophen Liver Injury
Authors: JERRY R. MITCHELL
Journal: Annals of Internal Medicine (1977)

Editorials1 September 1977Host Susceptibility and Acetaminophen Liver InjuryJERRY R. MITCHELL, M.D., PH.D.JERRY R. MITCHELL, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-3-377 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor most patients and consumers of over-the counter drugs, acetaminophen is safe when used appropriately. It is a good antipyretic, effectively relieves mild and moderate pain, and has minor anti-inflammatory action. The drug has become increasingly popular and is available without prescription in the United States under about 50 brand names and in 200 proprietary combinations with other drugs.Like many other therapeutic agents, the increasing use and availability of acetaminophen has turned up a darker side. In overdosage the drug causes acute centrilobular hepatic necrosis that may be fatal (1, 2), and acetaminophen poisoning is now one of the...References1. Editorial: Paracetamol hepatotoxicity. Lancet 2:1189-1191, 1975 MedlineGoogle Scholar2. Editorial: Paracetamol (acetaminophen) and the liver. Br Med J 1:536-537, 1975 CrossrefMedlineGoogle Scholar3. JAMESLESNAROBERTSPULMANDOUGLASSMITHWATSON OMSLAPA: Liver damage after paracetamol overdose. Comparison of liver-function tests, fasting serum bile acids, and liver histology. Lancet 2:579-581, 1975 CrossrefMedlineGoogle Scholar4. VOLANS G: Self-Poisoning and suicide due to paracetamol. J Int. Med Res 4(suppl 4):7-13, 1976 CrossrefMedlineGoogle Scholar5. Symposium on paracetamol and the liver. J Int Med Res 4(suppl 4)1-159, 1976 CrossrefMedlineGoogle Scholar6. BARKERDE CARLEANURAS JDS: Chronic excessive acetaminophen use and liver damage. Ann Intern Med 87:299-301, 1977 LinkGoogle Scholar7. JOHNSONTOLMAN GK: Chronic liver disease and acetaminophen. Ann Intern Med 87:302-304, 1977 LinkGoogle Scholar8. MITCHELLJOLLOW JD: Metabolic activation of drugs to toxic substances. Gastroenterology 68:392-410, 1975 CrossrefMedlineGoogle Scholar9. MITCHELLMCMURTRYSTATHAMNELSON JRCS: Molecular basis for several drug-induced nephropathies. Am J Med 62:518-526, 1977 CrossrefMedlineGoogle Scholar10. BOYDMITCHELL MJ: Role of pulmonary and renal metabolism in the pathogenisis of acute lung and kidney injury by xenobiotics in Progress in Drug Metabolism, Vol. 3, edited by BRIDGES JW, CHASSEAUD LF New York, Wiley and Sons, 1977, in press Google Scholar11. WALKERKELLEHERDIXONLOSOWSKY BJMM: Vitamin E protection of the liver from paracetamol in the rat. Clin Sci Mol Med 47:449-459, 1974 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Section on Clinical Pharmacology and Metabolism Office of the Director of Intramural Research National Heart, Lung, and Blood Institute Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Protective Effects of Garlic Extract Against Acetaminophen-Induced Oxidative Stress and Glutathione DepletionTREATMENT OF FEVERMinor analgesics and non-steroidal anti-inflammatory drugsTreatment of fever in childhoodParacetamol (acetaminophen) poisoningHepatotoxicity due to repeated intake of low doses of paracetamolAcetaminophen ToxicityNonnarcotic analgesic abuseIn vivo studies on toxic effects of concurrent administration of paracetamol and its ester (SUR 2647 combination)Acetaminophen-induced fulminant hepatic failure in DogsHepatotoxicity following the therapeutic use of antipyretic analgesicsTreatment of fever in 1982: A reviewDrug-induced Liver DiseaseIncreased hepatotoxicity of acetaminophen after chronic ethanol consumption in the ratParacetamol.Paracetamol (Acetaminophen) Clearance in Patients with Cirrhosis of the LiverAntipyretic analgesicsDrug-Induced Liver InjuryEffect of vitamin C on paracetamol hepatotoxicity 1 September 1977Volume 87, Issue 3Page: 377-378KeywordsAddictionDrugsLiverNecrosis Issue Published: 1 September 1977 PDF DownloadLoading ...