tbuckley/cabot-search huggingface dataset:
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension
Authors: Thomas G. Smith, Nick P. Talbot, Catherine Privat, Maria Rivera-Ch, Annabel H. Nickol, Peter J. Ratcliffe, Keith L. Dorrington, Fabiola León-Velarde, Peter A. Robbins
Journal: JAMA (2009)

Hypoxia is a major cause of pulmonary hypertension in respiratory disease and at high altitude. Recent work has established that the effect of hypoxia on pulmonary arterial pressure may depend on iron status, possibly acting through the transcription factor hypoxia-inducible factor, but the pathophysiological and clinical importance of this interaction is unknown.To determine whether increasing or decreasing iron availability modifies altitude-induced hypoxic pulmonary hypertension.Two randomized, double-blind, placebo-controlled protocols conducted in October-November 2008. In the first protocol, 22 healthy sea-level resident men (aged 19-60 years) were studied over 1 week of hypoxia at Cerro de Pasco, Peru (altitude 4340 m). In the second protocol, 11 high-altitude resident men (aged 30-59 years) diagnosed with chronic mountain sickness were studied over 1 month of hypoxia at Cerro de Pasco, Peru.In the first protocol, participants received intravenous infusions of Fe(III)-hydroxide sucrose (200 mg) or placebo on the third day of hypoxia. In the second protocol, patients underwent staged isovolemic venesection of 2 L of blood. Two weeks later, patients received intravenous infusions of Fe(III)-hydroxide sucrose (400 mg) or placebo, which were subsequently crossed over.Effect of varying iron availability on pulmonary artery systolic pressure (PASP) assessed by Doppler echocardiography.In the sea-level resident protocol, approximately 40% of the pulmonary hypertensive response to hypoxia was reversed by infusion of iron, which reduced PASP by 6 mm Hg (95% confidence interval [CI], 4-8 mm Hg), from 37 mm Hg (95% CI, 34-40 mm Hg) to 31 mm Hg (95% CI, 29-33 mm Hg; P = .01). In the chronic mountain sickness protocol, progressive iron deficiency induced by venesection was associated with an approximately 25% increase in PASP of 9 mm Hg (95% CI, 4-14 mm Hg), from 37 mm Hg (95% CI, 30-44 mm Hg) to 46 mm Hg (95% CI, 40-52 mm Hg; P = .003). During the subsequent crossover period, no acute effect of iron replacement on PASP was detected.Hypoxic pulmonary hypertension may be attenuated by iron supplementation and exacerbated by iron depletion.clinicaltrials.gov Identifier: NCT00952302.
Spring Books: Made a-purpose?
Authors: T. Smith
Journal: BMJ (1987)

As recently as 1979 a public opinion poll in the United States found that half of the adults questioned continued to believe that God had created Adam and Eve to start the human race.'Throughout America and especially in the southern Bible belt fundamentalist Christians are campaigning for laws requiring schools to teach that evolution is a theory not a fact and to acknowledge that alternative theories to evolution exist.Similar campaigns are being mounted in Australia.2At the other end of the spectrum theoretical physicists such as Stephen Hawking are "reasonably confident that we know the history of the universe up to one second after the Big Bang.What happens before that is much more speculative, but I think that after one second we're fairly confident."'How can it be that Hawking and his colleagues are teasing away at the events ofthat intellectually challenging first second while in the same world millions of Americans continue to believe that all the geological strata were laid down in one year after the flood described in the Bible?Faith and works
US abortion clinics afraid of new violence
Authors: F. Charatan
Journal: BMJ (2001)

Abortion clinics in the United States want greater safeguards because of what they feel are growing threats of violence against them and their staff.

Three abortion rights organisations—Planned Parenthood Federation of America, the National Abortion Federation, and the Feminist Majority Foundation—have called on President Bush's attorney general, John Ashcroft, to speak out against threats of violence at abortion clinics.

Their concerns are …
TCT-826 Does diabetic status impact the outcome of TAVR procedures? Insights from the France2 Registry
Authors: Eric Van Belle, Francis Juthier, André Vincentelli, Bernard Lung, Martine Gilard, Helene Eltchaninoff, Jean Fajadet, Marc Laskar, Carlo Banfi, Pascal Leprince, Alain Leguerrier, Alain Prat, Emmanuel Teiger
Journal: Journal of the American College of Cardiology (2012)
ABSTRACT OF NOTES ON THE TREATMENT OF EXOPHTHALMIC GOITRE.Read before the Section of Neurology and Medical Jurisprudence at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: J. MADISON TAYLOR
Journal: JAMA (1893)

Patients that become insane are to be sent to asy¬ lums in the districts from which they come, in accordance with the lunacy statutes.A special pathologist to reside in the community and devote his sole attention to the discovery of the causes and cure of epilepsy, is one of the features ultimately contemplated in connection with this great institution.This bill was, unfortunately, vetoed by Gov. Flower for reasons best known to himself, and the humane
Long-term risk for subsequent leukemia after treatment for childhood cancer: a report from the Childhood Cancer Survivor Study
Authors: Kerri Nottage, Jennifer Lanctot, Zhenghong Li, Joseph P. Neglia, Smita Bhatia, Sue Hammond, Wendy Leisenring, Anna Meadows, Deokumar Srivastava, Leslie L. Robison, Gregory T. Armstrong
Journal: Blood (2011)
Atypical skin lesions associated with mixed cryoglobulinaemia and hepatitis C virus infection in a cocaine‐consuming patient
Authors: D.N. Nan, M. Fernández‐Ayala, D. García‐Palomo, F. Arce, M.C. Fariñas
Journal: British Journal of Dermatology (2000)

Journal Article Atypical skin lesions associated with mixed cryoglobulinaemia and hepatitis C virus infection in a cocaine‐consuming patient Get access D.N. Nan, D.N. Nan Infectious Diseases Unit, Department of Internal Medicine; and *Department of Pathology; Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Avd. Valdecilla, s/n. 39008‐Santander, Spain Correspondence: M.Carmen Fariñas MD PhD. E‐mail: mirfac@humv.es Search for other works by this author on: Oxford Academic Google Scholar M. Fernández‐Ayala, M. Fernández‐Ayala Infectious Diseases Unit, Department of Internal Medicine; and *Department of Pathology; Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Avd. Valdecilla, s/n. 39008‐Santander, Spain Correspondence: M.Carmen Fariñas MD PhD. E‐mail: mirfac@humv.es Search for other works by this author on: Oxford Academic Google Scholar D. García‐Palomo, D. García‐Palomo Infectious Diseases Unit, Department of Internal Medicine; and *Department of Pathology; Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Avd. Valdecilla, s/n. 39008‐Santander, Spain Correspondence: M.Carmen Fariñas MD PhD. E‐mail: mirfac@humv.es Search for other works by this author on: Oxford Academic Google Scholar F. Arce, F. Arce Infectious Diseases Unit, Department of Internal Medicine; and *Department of Pathology; Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Avd. Valdecilla, s/n. 39008‐Santander, Spain Correspondence: M.Carmen Fariñas MD PhD. E‐mail: mirfac@humv.es Search for other works by this author on: Oxford Academic Google Scholar M.C. Fariñas M.C. Fariñas Infectious Diseases Unit, Department of Internal Medicine; and *Department of Pathology; Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Avd. Valdecilla, s/n. 39008‐Santander, Spain Correspondence: M.Carmen Fariñas MD PhD. E‐mail: mirfac@humv.es Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 6, 1 December 2000, Pages 1330–1331, https://doi.org/10.1046/j.1365-2133.2000.03918.x Published: 01 December 2000
Adverse reactions to measles immunisation
Authors: C Caffarelli, G Cavagni, F M Deriu, G F Zambelloni
Journal: BMJ (1994)

these values would not be.On the basis of validation work done in Britain on the Guy's score5 this would deprive about 5% of patients with infarcts of aspirin treatment, resulting in an increase of only about two preventable events per 1000 patients per three years.Delaying aspirin treatment for 30 days may also "result in an increase in some preventable events, but it is difficult to calculate how many and the number is probably not great.Until the results for the international stroke trial are available it is probably best to delay aspirin for 14 days anyway.The assumption that aspirin will cause rebleeding in all cases of haemorrhagic stroke is almost certainly pessimistic but is based on the axiom "first of all do no harm."
Women in Medicine
Authors: Amy Brodkey
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The two commentaries on women in medicine are disturbing in their sanguine assumption that equality has been won or is at least well on the way. The acceptance of this notion can only contribute to an increase in the subtle and overt forms of discrimination against women that are still present in American medicine. Numbers do not equal equality. The existence of a previous golden age for women in medicine at the turn of the century (which then, as now, was predicated on an active feminist movement) should give us pause; women were almost completely eliminated from the ranks of physicians in a few short years.<sup>1</sup>By and large, women still do not hold positions of power. Despite the progress cited by Drs Dimond and Heins, women in academic medicine are concentrated in lower ranks, are more likely to be part-time, less well paid and given
Poly(β-amino ester)–DNA complexes: Time-resolved fluorescence and cellular transfection studies
Authors: Elina Vuorimaa, Tiia-Maaria Ketola, Jordan J. Green, Martina Hanzlíková, Helge Lemmetyinen, Robert Langer, Daniel G. Anderson, Arto Urtti, Marjo Yliperttula
Journal: Journal of Controlled Release (2011)
Comparison of local risk factors for children's atopic symptoms in Hanoi, Vietnam
Authors: S. K. Chai, N. N. Nga, H. Checkoway, T. K. Takaro, G. J. Redding, M. C. Keifer, L. V. Trung, S. Barnhart
Journal: Allergy (2004)

Background: A 1999 study in Hanoi, Vietnam using the International Study on Asthma and Allergies in Childhood (ISAAC) questionnaire showed a high prevalence of atopic symptoms. Identifying risk factors for symptoms in these children may help in understanding the causes for these high estimates. Methods: An ISAAC questionnaire with supplemental questions on environmental variables was distributed to 5495 school children in Hanoi and a suburban district, Dong Anh. The response rate was 65.7%. Results: In Dong Anh, the following were among the significant age and gender adjusted associations: pig ownership [odds ratio (OR) (95% confidence interval), OR = 1.79 (1.18–2.70) for doctor‐diagnosed asthma (DDA), OR = 1.72 (1.08–2.78) for doctor diagnosed hay fever (DDHF)] and farming [OR = 1.67 (1.27–2.19) for ever asthma, OR = 1.51 (1.09–2.09) for DDHF]. In multivariate models, tuberculosis (TB) was a significant predictor of atopic symptoms [Hanoi: OR = 3.09 (1.10–8.70) for DDA, Dong Anh: OR = 3.71 (1.40–9.84) for DDA, OR = 4.66 (1.88–11.57) for DDHF]. Conclusions: These findings are contrary to the ‘hygiene hypothesis’. Recent immunologic and epidemiologic studies refute the inverse association between allergy and TB and may be one explanation for the positive association in this study. The positive association with pig ownership and farming may be because of exposures on farms in a developing country that may be different from exposures in farms of developed countries.
Physicians Who Have Lost Their Malpractice Insurance-Reply
Authors: William B. Schwartz
Journal: JAMA (1990)

<h3>In Reply.—</h3> Dr Howland incorrectly suggests that length of time in practice is the key determinant of whether a physician is likely to lose his or her malpractice insurance. In fact, insurance companies typically reach termination decisions without considering claims that occurred more than 5 (or at the most 10) years previously. Moreover, if tenure were the key to termination, one would expect to see older physicians in excess numbers in the "surplus-lines" pool. However, it is not older physicians but those in the 45- to 54-year age bracket who are overrepresented. As noted in our article, a physician's coverage is typically terminated in circumstances where he or she has a claims history that is substantially more adverse than others in the same specialty, or following an action by the state medical board. In the case of most physicianowned companies (which now insure about half of US practitioners), decisions are
Prevention of Bleeding in Older Patients Taking Warfarin
Authors: Alex C. Spyropoulos
Journal: Annals of Internal Medicine (2001)

Letters2 October 2001Prevention of Bleeding in Older Patients Taking WarfarinAlex C. Spyropoulos, MDAlex C. Spyropoulos, MDLovelace Health Systems; Albuquerque, NM 87108Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-7-200110020-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The well-designed study by Beyth and colleagues (1) showed that major bleeding events decreased significantly among older patients who received long-term oral anticoagulation through a multicomponent program that included patient self-testing, as compared with patients who received usual medical care prescribed by the treating physician. However, the study prompted the fundamental question of how this intervention would compare with what is rapidly becoming an important practice in many U.S. health care centers: nurse- or pharmacist-managed anticoagulation management services (AMS). The benefits of AMS over usual medical care, in terms of improved clinical outcomes (reduction in major bleeding ...References1. Beyth RJ, Quinn L, Landefeld C. A multicomponent intervention to prevent major bleeding complications in older patients receiving warfarin. A randomized, controlled trial. Ann Intern Med. 2000;133:687-95. [PMID: 11074901] LinkGoogle Scholar2. Gray DR, Garabedian-Ruffalo S, Chretien S. Cost-justification of a clinical pharmacist-managed anticoagulation clinic. Drug Intell Clin Pharm. 1985;19:575-80. [PMID: 3928310] CrossrefMedlineGoogle Scholar3. Wilt VM, Gums JG, Ahmed OI, Moore LM. Outcome analysis of a pharmacist-managed anticoagulation service. Pharmacotherapy. 1995;15:732-9. [PMID: 8602380] MedlineGoogle Scholar4. Chiquette E, Amato MG, Bussey HI. Comparison of an anticoagulation clinic with usual medical care: anticoagulation control, patient outcomes, and health care costs. Arch Intern Med. 1998;158:1641-7. [PMID: 9701098] CrossrefMedlineGoogle Scholar5. Samsa GP, Matchar DB, Goldstein LB, Bonito AJ, Lux LJ, Witter DM, et al . Quality of anticoagulation management among patients with atrial fibrillation: results of a review of medical records from 2 communities. Arch Intern Med. 2000;160:967-73. [PMID: 10761962] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Alex C. Spyropoulos, MDAffiliations: Lovelace Health Systems; Albuquerque, NM 87108 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Multicomponent Intervention To Prevent Major Bleeding Complications in Older Patients Receiving Warfarin Rebecca J. Beyth , Linda Quinn , and C. Seth Landefeld Metrics Cited byCurrent Awareness 2 October 2001Volume 135, Issue 7Page: 548KeywordsAnticoagulant therapyAnticoagulantsHealth careHemorrhageInternational normalized ratio ePublished: 2 October 2001 Issue Published: 2 October 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Treating exposure to chemical warfare agents: implications for health care providers and community emergency planning.
Authors: N B Munro, A P Watson, K R Ambrose, G D Griffin
Journal: Environmental Health Perspectives (1990)

Current treatment protocols for exposure to nerve and vesicant agents found in the U.S. stockpile of unitary chemical weapons are summarized, and the toxicities of available antidotes are evaluated. The status of the most promising of the new nerve agent antidotes is reviewed. In the U.S. atropine and pralidoxime compose the only approved antidote regimen for organophosphate nerve agent poisoning. Diazepam may also be used if necessary to control convulsions. To avoid death, administration must occur within minutes of substantial exposure together with immediate decontamination. Continuous observation and repeated administration of antidotes are necessary as symptoms warrant. Available antidotes do not necessarily prevent respiratory failure or incapacitation. The toxicity of the antidotes themselves and the individualized nature of medical care preclude recommending that autoinjectors be distributed to the general public. In addition, precautionary administration of protective drugs to the general population would not be feasible or desirable. No antidote exists for poisoning by the vesicant sulfur mustard (H, HD, HT); effective intervention can only be accomplished by rapid decontamination followed by palliative treatment of symptoms. British anti-Lewisite (BAL) (2,3-dimercapto-1-propanolol) is the antidote of choice for treatment of exposure to Lewisite, another potent vesicant. Experimental water-soluble BAL analogues have been developed that are less toxic than BAL. Treatment protocols for each antidote are summarized in tabular form for use by health care providers.
Hepatorenal failure with self-initiated intermittent rifampicin therapy.
Authors: D L Rothwell, D E Richmond
Journal: BMJ (1974)

Ease of Fixation.-Drillingthe skull and inserting screws is technically simple and much easier than wiring or suturing methods, which involve dissection of the bone edge and the extradural space.The use of an onlay technique considerably reduces the operating time.Good Tissue Acceptance.-Anodized titanium is an inert implant material.There is no reactive oedema of the scalp and no postoperative subgaleal effusion.Dead Space.-Previousmetal onlay techniques did not in- clude provision for obliterating the dead space between the plate and the dura.When there is a large space a heat-cured acrylic resin mass can be processed to the tissue fitting sur- face of the plate (fig. 7).Radiolucency.-Anobjection to most metallic plates is that they are radio-opaque.Titanium, however, is sufficiently radio- lucent to allow radiological studies (see fig. 6).Strength.-Whentitanium sheet is shaped to a formed con- tour it becomes rigid and will withstand considerable external force.As -the plate is 05-1 cm "oversize," only an exceptional force would displace it inwards.Lightness.-Thedensity of titanium is low compared with that of other metals and alloys.Sterilization.-Titanium plates and screws can be auto- claved.As most plastic materials need protection to prevent deformation due to stress relief on heating their sterility cannot be guaranteed.
Can pemphigoid be provoked by lisinopril?
Authors: A. Kalińska-Bienias, T.T. Rogoziński, K. Woźniak, C. Kowalewski
Journal: British Journal of Dermatology (2006)

Journal Article Can pemphigoid be provoked by lisinopril? Get access A. Kalińska‐Bienias, A. Kalińska‐Bienias Department of Dermatology, Warsaw Medical University, 02‐008 Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar T.T. Rogoziński, T.T. Rogoziński Department of Dermatology, Warsaw Medical University, 02‐008 Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar K. Woźniak, K. Woźniak Department of Dermatology, Warsaw Medical University, 02‐008 Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar C. Kowalewski C. Kowalewski Department of Dermatology, Warsaw Medical University, 02‐008 Warsaw, Poland Cezary Kowalewski. E‐mail: ckowalew@amwaw.edu.pl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 4, 1 October 2006, Pages 854–855, https://doi.org/10.1111/j.1365-2133.2006.07453.x Published: 01 October 2006
Randomized Clinical Trials in Single Patients
Authors: William MacMilan Rodney
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Single patient trials (SPTs) as described by Dr Larson and colleagues<sup>1</sup>are an important approach to resolving some of the therapeutic questions faced in practice. I would like the authors to clarify the issue of costs. Currently, licensed residents in the Memphis, Tenn, area can moonlight for a starting wage of $50 per hour. Using the data provided by Larson et al (16.75 staff hours with estimated direct costs of $450 to $500 per trial), the cost is approximately $30 per hour. If staff time is to be calculated using physicians, shouldn't these figures be adjusted upward? Single patient trials are important tools for professional development, not only among full-time faculty, but particularly among clinical faculty. In this academic department of family medicine, academic faculty "cost" more than $60 per hour in salary and benefits. Even with these upward adjustments, participation in an SPT service should
The Use of Doxepin in the Treatment of Symptoms of Anxiety Neurosis and Accompanying Depression: A Collaborative Controlled Study
Authors: HAROLD L. GOLDBERG, RICHARD J. FINNERTY
Journal: American Journal of Psychiatry (1972)

Fifty-two outpatients with the main target symptom of anxiety with accompanying depression were randomly assigned to receive either doxepin or placebo in a double-blind study for four weeks. The doxepin group improved significantly on global ratings at one week and at four weeks. It was found that at one week patients were significantly improved on symptoms of anxiety, while at four weeks significant improvement occurred in depressive symptomatology.
CORTICOTROPIN AND CORTISONE IN MANAGEMENT OF THE NEPHROTIC SYNDROME IN CHILDREN
Authors: Conrad M. Riley
Journal: JAMA (1952)

About three years have elapsed since corticotropin (ACTH) and cortisone were first used in treatment of the nephrotic syndrome. Although this is not enough time to evaluate fully the role of a new treatment in a disease with such a prolonged natural course, enough experience has been gained to justify some definite conclusions and to suggest other probabilities. That these hormones are of importance in the management of nephrosis is attested to by the many papers that have appeared reporting small experiences with them; a fairly complete bibliography can be found in two recent reports by Rapoport and co-workers<sup>1</sup>and Luetscher and co-workers.<sup>2</sup>The results reported have been in general agreement. The purpose of this article is to summarize the results of my experience with both corticotropin and cortisone in a fairly large group of patients at one institution, with attention to not only the immediate effects but
“American Values” — A Smoke Screen in the Debate on Health Care Reform
Authors: Allan S. Brett
Journal: New England Journal of Medicine (2009)

Amid all the rhetoric about health care reform, one claim has emerged as a trump card designed to preserve the current patchwork of private and public insurance and to stop discussion of a government-sponsored single-payer system in its tracks: the claim that single-payer health care — a Canadian-style Medicare-for-all system — is antithetical to "American values." The idea that American values dictate a particular approach to health care reform is often stated explicitly, and it is implicit in the generalization that "Americans want" a particular system. The underlying premise is that an identifiable set of American values point incontrovertibly to . . .