tbuckley/cabot-search huggingface dataset:
ACCF/AHA/AMA-PCPI 2011 Performance Measures for Adults With Heart Failure
Authors: Robert O. Bonow, Theodore G. Ganiats, Craig T. Beam, Kathleen Blake, Donald E. Casey, Sarah J. Goodlin, Kathleen L. Grady, Randal F. Hundley, Mariell Jessup, Thomas E. Lynn, Frederick A. Masoudi, David Nilasena, Ileana L. Piña, Paul D. Rockswold, Lawrence B. Sadwin, Joanna D. Sikkema, Carrie A. Sincak, John Spertus, Patrick J. Torcson, Elizabeth Torres, Mark V. Williams, John B. Wong
Journal: Circulation (2012)
STUDIES IN ISOAGGLUTINATION
Authors: Reuben Ottenberg, S. S. Friedman
Journal: The Journal of Experimental Medicine (1911)

Grouped isoagglutination is not limited to man, but is much more widespread than has been hitherto suspected. It occurs in the bloods of steers and rabbits. It seems probable that it will be found to occur in the bloods of other animals. Just how many of the isoagglutinins and the isoagglutinable substances in different species are respectively identical is still to be determined. The work is being continued with other animals.
Do baseline c-reactive protein levels predict myocardial salvage after reperfusion therapy in patients with acute myocardial infarction?
Authors: Alban Dibra, Julinda Mehilli, Helmut Schuehlen, Juergen Pache, Jodi Neverve, Adnan Kastrati, Albert Schomig
Journal: Journal of the American College of Cardiology (2003)
Redifferentiation of Iodine-Refractory <i>BRAF</i> V600E-Mutant Metastatic Papillary Thyroid Cancer with Dabrafenib
Authors: S. Michael Rothenberg, David G. McFadden, Edwin L. Palmer, Gilbert H. Daniels, Lori J. Wirth
Journal: Clinical Cancer Research (2014)

To determine whether the selective BRAF inhibitor, dabrafenib, can stimulate radioiodine uptake in BRAF V600E-mutated unresectable or metastatic iodine-refractory papillary thyroid cancer (PTC).Ten patients with BRAF V600E-mutant iodine-refractory PTC were enrolled. Absence of radioiodine uptake on iodine-131 whole body scan obtained within 14 months of study entry was required. Each patient received dabrafenib (150 mg twice daily) for 25 days before thyrotropin α-stimulated iodine-131 whole body scan (4 mCi/148 MBq). Patients whose scan showed new sites of radioiodine uptake remained on dabrafenib for 17 more days, and then were treated with 150 mCi (5.5 GBq) iodine-131. The primary endpoint of the study was the percentage of patients with new radioiodine uptake after treatment with dabrafenib.Six of 10 patients (60%) demonstrated new radioiodine uptake on whole body scan after treatment with dabrafenib. All 6 were treated with 5.5 GBq iodine-131. Two patients had partial responses and 4 patients had stable disease on standard radiographic restaging at 3 months. Thyroglobulin decreased in 4 of 6 treated patients. One patient developed squamous cell carcinoma of the skin. There were no other significant adverse events attributed to dabrafenib.Dabrafenib can stimulate radioiodine uptake in patients with metastatic BRAF V600E-mutant iodine-refractory PTC, representing a potential new therapeutic approach for these patients.
SINGLE NUCLEOTIDE POLYMORPHISMS IN CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENE ARE NOT ASSOCIATED WITH RECURRENT CARDIOVASCULAR EVENTS OR MORTALITY IN PATIENTS WITH ESTABLISHED ATHEROSCLEROSIS: A MENDELIAN RANDOMIZATION EXPERIMENT
Authors: Salim S. Virani, Vei-Vei Lee, Ariel Brautbar, Megan Gove-Goana, Vijay Nambi, Mahboob Alam, MacArthur Elayda, James Wilson, James Willerson, Eric Boerwinkle, Christie Ballantyne, Michael E. DeBakey
Journal: Journal of the American College of Cardiology (2013)
Diameter change and pressure-red blood cell velocity relations in coronary microvessels during long diastoles in the canine left ventricle.
Authors: H Kanatsuka, K Ashikawa, T Komaru, T Suzuki, T Takishima
Journal: Circulation Research (1990)

The objective of this study was to determine whether coronary vascular resistance remains constant during long diastoles and whether critical closure of arterial microvessels occurs at zero-flow pressure. For this purpose, we directly measured internal diameters and red blood cell velocities in arterial and venous coronary microvessels during long diastoles under maximal vasodilation. The epicardial coronary microcirculation was viewed in anesthetized, open-chest mongrel dogs through an intravital microscope equipped with a newly developed floating objective. Coronary microvascular diameters and red blood cell velocities were measured with high-speed cinematography. During maximal vasodilation (150 micrograms/kg body wt i.v. dilazep), long diastoles were induced by vagal nerve stimulation. Internal diameters of all small arteries and arterioles (n = 12) gradually declined with decreasing aortic pressure during long diastoles, and the reduction of the diameter was greatest when aortic pressure was less than 35 mm Hg. The mean internal diameter (88.8 +/- 52.2 microns) at minimal aortic pressure (19.2 +/- 6.4 mm Hg) was significantly less than that at an aortic pressure of 100 mm Hg (116.2 +/- 68.5 microns, p less than 0.01). The internal diameters of small veins and venules remained nearly constant during long diastoles. When red blood cell progression in coronary microvessels stopped at the nadir of aortic pressure, all arterial coronary microvessels remained open; that is, there was no evidence of "critical closure."(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 861: Nrf2-mediated induction of heme oxygenase-1 expression by cyclopentenone prostaglandin analogues in human breast epithelial cells: Structure-activity relationships
Authors: Jong-Min Park, Nam-Jung Kim, Hye-Kyung Na, Young-Ger Suh, Young-Joon Surh
Journal: Cancer Research (2011)

Abstract 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of peroxisome proliferator-activated receptor γ, has been known to induce heme oxygenase-1 (HO-1) in certain cell lines. The mechanism by which 15d-PGJ2 upregulates HO-1 expression is considered to involve covalent modifications of critical cysteine residues of Keap1, a cytoplasmic repressor of Nrf2. This facilitates dissociation of Nrf2 from Keap1 for nuclear translocation and binding to the antioxidant response element. In the present work, we synthesized a series of 15d-PGJ2 analogues: i) Halogenated 15d-PGJ2 derivatives by introducing an electron withdrawing group, i.e., halogen into the electrophilic carbon; ii) Olefin modified 15d-PGJ2 analogues by saturating an electrophilic α,β-unsaturated carbonyl moiety in the cyclopentenone ring; iii) Combined halogenated and olefin modified 15d-PGJ2 analogues with more potent electrophilic nature to form stable Keap1 adducts. Twelve 15d-PGJ2 analogues were synthesized that retain the essential structural features of 15d-PGJ2 with different capabilities to induce Nrf2 activation. When treated to the human breast epithelial cell line (MCF10A), halogenated 15d-PGJ2 analogues were found to have high potency and efficacy for inducing HO-1 expression as well as Nrf2 activation (-Cl &amp;gt; -Br &amp;gt; -F = -I). 14,15-Dihydro-PGJ2 also retains capability to induce HO-1 expression and Nrf2 activation. However, abilities of both 9,10-dihydro-15d-PGJ2 and 12,13-14,15-tetrahydro-PGJ2 to induce HO-1 expression and Nrf2 activation were abolished due to lack of the electrophilic α,β-unsaturated carbonyl moiety. Chlorinated 14,15-dihydro-PGJ2 has the highest potency and efficacy for HO-1 induction via Nrf2 activation. We further showed that biotinylated 15d-PGJ2 directly bound to Keap1, which was confirmed by avidin pull-down. Biotinylated chloro 14,15-dihydro-PGJ2 interacted with Keap1 to a greater extent than did 15d-PGJ2. In contrast to 15d-PGJ2, 9,10-dihydro-15d-PGJ2 failed to modify Keap1. Taken together, these results suggest that 15d-PGJ2 containing an electrophilic cyclopentenone moiety can directly modify Keap1, presumably at its critical cysteine residue. As halogenated 15d-PGJ2 analogues and 14,15-dihydro-PGJ2 can stably interact with Keap1, they can be utilized as lead compounds for the development of anti-inflammatory and chemopreventive agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 861. doi:10.1158/1538-7445.AM2011-861
&lt;emph type="ital"&gt;Wall of Light&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence and Causes of Secondary Failure in Treatment with Tolbutamide
Authors: Rafael A. Camerini-Dávalos
Journal: JAMA (1962)

The causes of secondary failure with tolbutamide therapy were studied in 1,965 diabetic patients. Among the 432 failures (22% of the total), 81 occurred during the first year, 162 during the second, 127 during the third, 51 during the fourth, and 11 during the fifth year of treatment. Factors considered responsible were: (1) unwise initial selection of patients, 5.6%; (2) poor diet adherence, 3.5%; (3) inadequate dosage of drug, 8.3%; and (4) temporary failure due to metabolic stress, 0.9%; which left a balance of 3.7% due to unexplained drug failure. It is concluded that true late unresponsiveness to tolbutamide is less common than has been reported by some. Furthermore, among 127 patients who resumed insulin, the requirement was equal to or lower than that before sulfonylurea treatment in 74, and in only 17 patients was it greater by 20% or more.
Clinical Response to Fluorouracil and<i>p53</i>
Authors: Leonard H. Augenlicht, Scott Wadler, Diego Arango
Journal: New England Journal of Medicine (2001)

To the Editor: Accurate identification of phenotype is critical for precise genetic characterization.Standard textbooks define the Wolff-Parkinson-White syndrome as the combination of a short PR interval, an increased duration of the QRS complex caused by an initial slow deflection (delta wave), and supraventricular tachyarrhythmias. 1,2 The phenotype identified by Gollob et al. (June 14 issue) 3 is based on "a short PR interval (<120 msec) with a widened QRS complex (>110 msec) or an abnormal initial QRS vector (a delta wave)."Failure to specify that the widened QRS complex must be due to the slow initial delta wave and failure to require the presence of supraventricular arrhythmias result in a much looser definition.No data on the sensitivity or specificity of this definition are provided.Ventricular preexcitation may be intermittent; therefore, the sensitivity is less than 100 percent.The specificity is likely to be very low in this study because of the unusually high incidence of disorders that cause QRS abnormalities in the two families.In contrast, observations in a previous study of familial Wolff-Parkinson-White syndrome showed that structural changes were rare. 4 Most surprising is the fact that complete atrioventricular block, which would require loss of conduction over both normal and accessory pathways, developed in several affected persons.Finally, electrophysiological studies were performed in only eight patients, and several of these studies demonstrated atypical features. 2Therefore, the accuracy of the Wolff-Parkinson-White syndrome phenotype in this study is uncertain, and this may account for the difficulty in linking the physiological function of the identified gene product with the development of the Wolff-Parkinson-White syndrome.
Linking adiponectin to proteinuria
Authors: Rexford S. Ahima
Journal: Journal of Clinical Investigation (2008)

Obesity predisposes toward renal disease independently of diabetes and hypertension. In this issue of the JCI, Sharma and colleagues assessed the role of adiponectin, an adipose-derived hormone, in the pathogenesis of albuminuria (see the related article beginning on page 1645). Obese African Americans had reduced adiponectin levels associated with albuminuria. Adiponectin deficiency in mice induced oxidative stress, fusion of podocyte foot processes in the kidney glomerulus, and urinary albumin excretion. Adiponectin treatment reversed these abnormalities, likely through activation of AMPK. The benefits of adiponectin were observed in diabetic and nondiabetic mice. These findings suggest that adiponectin is a biomarker for kidney disease and may be targeted for prevention and treatment.
Malignant melanoma arising from cutaneous bronchogenic cyst of the scapular area
Authors: Muneo Tanita, Katsuko Kikuchi-Numagami, Kennichirou Ogoshi, Toshiaki Suzuki, Nobuko Tabata, Kazuhiro Kudoh, Takaki Suetake, Tohru Takahashi, Hachiro Tagami
Journal: Journal of the American Academy of Dermatology (2002)
TUBERCULOSIS OF THE MAMMARY GLAND.
Authors: ALBERT H. FREIBERG
Journal: JAMA (1898)

Until very recent times tuberculosis of the breast has been considered one of the rarest surgical conditions; this is especially true of primary tuberculosis of this gland. Prior to 1880 we find practically no mention of this condition in surgical treatises save by Astley Cooper and Velpeau. Billroth, in his monograph on diseases of the breast, regarding all previous reports on this subject as inaccurate and lacking histologic confirmation, mentions a case of undoubted tuberculosis of the breast found postmortem in a woman who had died of pulmonary and intestinal tuberculosis. Since this time reports of these cases have multiplied, although the total number of authenticated cases of primary tuberculosis is still considerably below fifty. Of this number less than ten have been contributed by our own countrymen, two of them having been reported by Powers of Denver. In view of the fact that the diagnosis is by no means
Abstract 1378: Identification and characterization of small molecule inhibitors targeting Eya phosphatase activity for anti-breast cancer therapy
Authors: Aaron Krueger, Seameen Dehdashti, Noel Southhall, Samarjit Patnaik, Juan Marugan, Wei Zheng, Heide Ford, Rui Zhao
Journal: Cancer Research (2011)

Abstract Eya proteins are transcriptional co-activators of the homeobox gene Six1 and are also unique protein tyrosine phosphatases. Six1 and Eya2 are required for normal development but are down-regulated in most adult tissues. However, Six1 and Eya are over-expressed in a large number of breast tumors and play a causal role in the initiation and development of these tumors. The phosphatase activity of Eya was shown to be important for the transformation, migration, invasion, and metastasis of breast cancer cells. Eya's phosphatase activity therefore provides an attractive enzymatic target for anti-breast cancer therapy. In addition, Eyas also direct cells to a DNA-damage-repair pathway instead of an apoptotic pathway upon DNA damage through the dephosphorylation of histone H2AX. Inhibiting Eya phosphatase activity can therefore potentially sensitize tumor tissue to radiation or chemotherapy treatment. We developed an HTS assay to identify small molecule inhibitors of Eya's phosphatase activity. In collaboration with the NIH Chemical Genomics Center, we have screened over 300,000 compounds and identified several promising lead compounds. These hits are currently being evaluated for their potency, specificity, and mechanism of action using biochemical, structural, and cell-based assays. We believe that Eya is a significant target for cancer therapy through sensitizing cancer cells to radiation and chemotherapy and through the inhibition of Six1-mediated tumorigenesis and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1378. doi:10.1158/1538-7445.AM2011-1378
What do we gain from the sixth coronary heart disease drug?
Authors: R. N Warburton
Journal: BMJ (2003)

Not much: guidelines must consider cost effectiveness 

From air travel to patient safety to coronary heart disease prevention, people strive to reduce risk to zero. We know that zero risk is unattainable, yet we pursue perfection. It may be useful to hold perfection as an ideal,1 but there can be great harm in trying to achieve it because near perfection often imposes near infinite costs. The closer we get to perfect risk reduction, the more likely it becomes that we could have got a better bang for our preventive buck somewhere else. This applies across all activities–and needs to be heeded in health care as anywhere else.

For example, air travel is already much safer than most other forms of travel, so £10m ($17m; €14m) spent on road safety would save far more life years than £10m put into tightening airport security. Yet since September 11 much new spending has gone into airport security. In health too we often see a rush to perfection without regard for costs. Here are three examples. Firstly, universal precautions to prevent worksite transmission of HIV to healthcare workers have been widely implemented, yet cost …
Workmen's Compensation for Psychiatric Disorders
Authors: Norman Q. Brill
Journal: JAMA (1965)

The concept of workmen's compensation for employees with industrial accidents has been so expanded that it includes many disorders in which the causal relationship between the special hazards of employment and the illness becomes increasingly obscure. In Carter vs General Motors, a precedent was established of compensating an employee for a psychiatric breakdown not associated with any physical injury, accident, specific event, or unusual stress or incident. To help avoid the perversion of the original intent of workmen's compensation, industry will have to concern itself with emotional as well as physical requirements of its employees, without diminishing the individual's sense of responsibility for his own welfare.
Copper-Induced Acute Hemolytic Anemia
Authors: ALAN D. MANZLER
Journal: Annals of Internal Medicine (1970)

Three episodes of copper-induced acute hemolysis after hemodialysis in two patients and two uneventful exposures to copper in a third patient are reported. The clinical syndrome of copper intoxication is described. Contaminated dialysate was caused by copper that was released from copper tubing in the dialysate-making equipment when a deionizing system was exhausted, allowing acid water to be delivered to the dialysate-making equipment. Dialysate and plasma copper levels are correlated with symptoms and hemolysis. Corrections have been made to eliminate this potentially lethal complication of hemodialysis.
Lichenoid vasculitis associated with myeloproliferative disorder: successful treatment with dapsone.
Authors: T.C. Ling, J.R. Kendra, A. Al-Dawoud, I.H. Coulson
Journal: British Journal of Dermatology (2001)

Sir, We report a patient with chronic cutaneous vasculitis with an unusual lichenoid appearance, associated with myelofibrosis and an extra copy of chromosome 9. A 69‐year‐old man presented with a 5‐year history of an initially transient skin eruption affecting his thighs, lower legs and ankles. Each attack lasted for several days before subsiding. After 2 years, some of the lesions, particularly those on the lower legs, became fixed, violaceous and flat‐topped (Fig. 1). He had a history of carcinoma of the prostate and recurrent deep venous thrombosis. At presentation, he was receiving goserelin injections and long‐term warfarin (both of which antedated the eruption by several years). Examination revealed a palpable purpuric rash typical of small vessel leucocytoclastic vasculitis on his thighs and lower legs, but the eruption around his ankles had a striking lichenoid appearance with a purple colour. Splenomegaly (5 cm below costal margin) was noted but no lymphadenopathy or hepatomegaly. He was afebrile and systemically well. His mucous membranes were normal.
Effect of heart rate on myocardial relaxation in isometric twitches
Authors: O. N Nwasokwa
Journal: Cardiovascular Research (1994)

Increased heart rate increases the amount of calcium that triggers myofilament interaction and thereby the load of calcium to be sequestered to cause relaxation, while decreasing the time for calcium sequestration. By studying the effect of heart rate on myocardial relaxation the hypothesis was therefore tested that increased heart rate impairs myocardial relaxation.In situ blood-perfused right ventricular papillary muscles of seven isolated Suga-Sagawa cross circulated canine hearts were studied with a servo system that clamped muscle length to produce isometric force, F(t), at one isometric length in each muscle at paced heart rates within the range 100-150. Each curve of F(t) was fitted, by Marquardt's algorithm, with the relation F(t) = C(t/A)B(e)1-(t/A)B. It was previously shown that the parameter B reflects changes in relaxation, whereas the parameters A and C reflect chronotropic and inotropic states. Changes in B reflect changes in the time course of relaxation that are not simply due to changes in total twitch duration guaranteed to be produced by altered heart rate. Linear regression analysis was performed on data from each muscle to determine whether each of the parameters A, B, and C changed significantly with heart rate.The mean coefficient of determination, a measure of goodness of fit of the model to observed data, was 0.996(SD 0.001). With increase in heart rate, A and C increased significantly in six of the seven muscles. On the other hand B did not show significant change with heart rate in six of the seven muscles; in the seventh muscle, B increased significantly with heart rate. Similar results were obtained when other indices of lusitropy were used.Increase in heart rate does not impair myocardial lusitropy as measured by the parameter B which reflects changes in the time course of relaxation independent of change in total time course of mechanical activity.
Lymphopenic response of patients presenting with chronic lymphocytic leukemia associated with carcinoma of the prostate to diethylstilbestrol: Correlation of response to the in vitro synthesis of rna by patient lymphocytes and its relationship to transcortin
Authors: Parthasarathy Narasimhan, Leonard Amaral
Journal: American Journal of Hematology (1980)

Abstract Three patients with chronic lymphocytic leukemia (CLL) and carcinoma of the prostate were treated for the latter condition with diethylstilbestrol (DES). All three patients responded with rapid reductions in their peripheral white counts. The previously observed lymphocytic infiltration of the bone marrow of one patient was not evident after three months of DES treatment. The response of this patient to DES correlates well with the enhanced level of plasma transcortin subsequent to treatment. Treatment of this patient with DES alters the ability of peripheral lymphocytes to incorporate radioactive uridine into RNA as well as the in vitro response to either cortisol or β‐estradiol.
Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells
Authors: Fernando E. Sepulveda, Sophia Maschalidi, Renaud Colisson, Lea Heslop, Cristina Ghirelli, Emna Sakka, Ana-Maria Lennon-Duménil, Sebastian Amigorena, Lucien Cabanie, Bénédicte Manoury
Journal: Immunity (2009)