tbuckley/cabot-search huggingface dataset:
Hyperpiesis: high blood-pressure without evident cause: essential hypertension.
Authors: G. Pickering
Journal: BMJ (1965)

The benign phase of hypertension offers a great contrast to the malignant phase. The course is long and variable, with the condition often remaining unchanged for years ; thus, of Bechgaard's original 1,038 patients, 357 were alive after 20 years (Bechgaard et al., 1956). Bechgaard (unpublished) has recently reported that 144 were alive after 26 to 32 years. Uraemia does not occur ; bilateral neuroretinopathy does not occur ; cerebral oedema does not occur, or occurs only rarely ; patients tend to die of heart failure, cerebral vascular disease, or intercurrent disease. Its nature is clearly different. The malignant phase is characterized by lesions which represent the limit of cardiovascular tolerance, fibrinoid arteriolar necrosis, retinal exudates representing focal vascular damage, hypertensive fits of similar origin, left ventricular failure in response to overloading. While each phenomenon is dependent also on other factors, thus accounting for some variation, few patients fail to exhibit at least two of these phenomena. In the benign phase the relationship between arterial pressure and the lesions that kill or cripple the patient seem to be less close ; factors other than arterial pressure intrude more. Hence for a given grade of elevated arterial pressure we have a much greater variability in duration of life and course of illness ; so much so that some patients live their full span1 and die of unrelated disease.
Pemphigus foliaceus associated with silicosis
Authors: H. Ueki, J. Takao, F. Yamasaki, N. Yoda, M. Yamaguchi, M. Kohda
Journal: British Journal of Dermatology (2000)

Journal Article Pemphigus foliaceus associated with silicosis Get access H. Ueki, H. Ueki Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki 701–0192, Okayama‐ken, Japan Search for other works by this author on: Oxford Academic Google Scholar J. Takao, J. Takao Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki 701–0192, Okayama‐ken, Japan Search for other works by this author on: Oxford Academic Google Scholar F. Yamasaki, F. Yamasaki Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki 701–0192, Okayama‐ken, Japan Search for other works by this author on: Oxford Academic Google Scholar N. Yoda, N. Yoda Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki 701–0192, Okayama‐ken, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Yamaguchi, M. Yamaguchi Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki 701–0192, Okayama‐ken, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Kohda M. Kohda Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki 701–0192, Okayama‐ken, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 2, 1 August 2000, Pages 456–457, https://doi.org/10.1046/j.1365-2133.2000.03687.x Published: 01 August 2000
Noninvasive Evaluation of Bone-Forming Activity Within the Calcified Atherosclerotic Lesions by Tc 99m HMDP Scintigraphy
Authors: Nobuhiro Tahara, Atsuko Tahara, Akihiro Honda, Yoshikazu Nitta, Sachiyo Igata, Yukihiko Nakamura, Yasuharu Takeuchi, Hidetoshi Akashi, Hiroyuki Tanaka, Motohiro Morioka, Jagat Narula, Sho-ichi Yamagishi, Yoshihiro Fukumoto
Journal: JACC. Cardiovascular imaging (2014)
Granular acute lymphoblastic leukemia: A case report and literature review
Authors: Sean D. Pitman, Qin Huang
Journal: American Journal of Hematology (2007)

Authors report a rare case of granular acute lymphoblastic leukemia (ALL) in a 45-year-old woman with a history of multiple myeloma. The patient's lymphoblasts contained large numbers of distinctive cytoplasmic granules closely mimicking heavily granulated myeloblasts in acute myeloid leukemia. These blasts were completely negative for myeloperoxidase but positive for acid phosphatase and Periodic Acid-Schiff reaction by cytochemical staining. Immunophenotype analysis by immunohistochemistry clearly demonstrated precursor B-cell phenotype. Granular ALL occurs approximately 2 to 7% in childhood populations but is extremely rare in adults. Such cases may cause problematic distinction from myeloid differentiation and lead to misdiagnosis of acute myeloid leukemia. Ten cases of adult granular acute lymphoblastic leukemia described to date in the literature were also reviewed.
Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties
Authors: Kay Vogel, Nicole Blümer, Melanie Korthals, Jessica Mittelstädt, Holger Garn, Markus Ege, Erika von Mutius, Sören Gatermann, Albrecht Bufe, Torsten Goldmann, Karin Schwaiger, Harald Renz, Sven Brandau, Johann Bauer, Holger Heine, Otto Holst
Journal: Journal of Allergy and Clinical Immunology (2008)
THE ETIOLOGY AND THE PATHOLOGY OF BRONCHOPNEUMONIA COMPLICATING MEASLES.
Authors: CHAS. F. CRAIG
Journal: JAMA (1905)

Bronchopneumonia is recognized as the most fatal complication of measles. While the pathology of the condition has been thoroughly investigated, there is yet much to learn regarding the etiology and the more minute pathologic changes which occur in the tissues. Many epidemics of bronchopneumonia following measles differ markedly in their clinical and pathologic features, and it is impossible to believe that such epidemics are always due to the same etiologic factor. The occurrence of an epidemic of measles in one of the posts of the Department of California, many of the patients being sent to the U. S. Army General Hospital at San Francisco for treatment, and the complication of this condition by bronchopneumonia which occurred in a considerable proportion of these cases, has given me an opportunity to study minutely the pathology of this condition. In all, 89 cases were sent to this hospital for treatment; in 12 cases, nearly 13.5
Clinical efficacy of the amplified Mycobacterium tuberculosis direct test for the diagnosis of pulmonary tuberculosis.
Authors: S P Bradley, S L Reed, A Catanzaro
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

The amplified Mycobacterium tuberculosis direct test (MTD) is a rapid diagnostic test based on a nucleic acid amplification technique, which can be used directly on processed clinical specimens. We evaluated the clinical utility of the MTD for diagnosing pulmonary tuberculosis by comparing the sensitivity and specificity of the test with acid-fast smear, mycobacterial culture, and clinical evaluation. The study included 844 respiratory tract specimens from 421 patients, which were submitted to the microbiology laboratory of our urban teaching hospital over a 6-mo period. Compared with culture, MTD had a sensitivity of 93.6% and specificity of 97.8%. MTD was more sensitive in detecting pulmonary tuberculosis in patients with previously undiagnosed disease (74.7%) than in those with established disease receiving chemotherapy (29.2%), and in smear-positive (95.5%) than in smear-negative (70.0%) disease. There were two false positive MTD results in patients with nontuberculous mycobacteria, for a specificity in this population of 97.3%. We conclude that MTD, when used in conjunction with routine smear and culture, is a useful rapid diagnostic test for suspected pulmonary tuberculosis.
P742 THE PHARMACOKINETICS OF GS-5816, A PAN-GENOTYPIC HCV NS5A INHIBITOR, IN HCV-UNINFECTED SUBJECTS WITH MODERATE AND SEVERE HEPATIC IMPAIRMENT
Authors: E. Mogalian, A. Mathias, D. Brainard, J. McNally, L. Moorehead, M. Hernandez, R. Perry, C. Curtis, E. Lawitz, K. Lasseter, T. Marbury
Journal: Journal of Hepatology (2014)
Ciclesonide, a new inhaled corticosteroid, significantly improves asthma-related quality of life in patients with severe, persistent asthma
Authors: D. Bernstein, R. Nathan, D. Ledford, E. Ledoux, A. Pedinoff, C. Crivera, J. Williams, S. Kundu, J. Fish, D. Banerji
Journal: Journal of Allergy and Clinical Immunology (2005)
Disturbance of the menstrual pattern after local injection with triamcinolone acetonide
Authors: J. M A MENS, A N. DE WOLF, B. J BERKHOUT, H. J STAM
Journal: Annals of the Rheumatic Diseases (1998)

Local injections of corticosteroids are often used in the treatment of various locomotor disorders. A notable part of injected corticosteroids is absorbed into the circulation.1-8 This may cause systemic effects. In our practice, a few patients have complained of abundant menstruation after local injection of corticosteroids. A MEDLINE literature search was carried out for the period 1966–1996. Evidence was found that triamcinolone acetonide (TA) influenced menstruation after intramuscular application,9-13 but no literature was found about disturbance of the menstrual pattern after intra-articular or periarticular corticosteroid injections and because knowledge of the possible side effect is important for medical practice it was decided to investigate this phenomenon.

Seventy seven premenopausal women (mean age 34.6 (SD 9.0) years) were included who were about to be given a first local injection of …
Long-term Postinjury Functional Recovery
Authors: Areti Tillou, Lorraine Kelley-Quon, Sigrid Burruss, Eric Morley, Henry Cryer, Marilyn Cohen, Lillian Min
Journal: JAMA Surgery (2013)

Functional recovery is an important outcome following injury. Functional impairment is persistent in the year following injury for older trauma patients.To measure the impact of routine geriatric consultation on functional outcomes in older trauma patients.In this pretest-posttest study, the pretest control group (n = 37) was retrospectively identified (December 2006-November 2007). The posttest geriatric consultation (GC) group (n = 85) was prospectively enrolled (December 2007-June 2010). We then followed up both groups for 1 year after enrollment. This study was conducted at an academic level 1 trauma center with adults 65 years of age and older admitted as an activated code trauma.Routine GC.The Short Functional Status survey of 5 activities of daily living (ADLs) at hospital admission and 3, 6, and 12 months postinjury.The unadjusted Short Functional Status score (GC group only) declined from 4.6 preinjury to 3.7 at 12 months postinjury, a decline of nearly 1 full ADL (P < .05). The ability to shop for personal items was the specific ADL more commonly retained by the GC group compared with the control group. The GC group had a better recovery of function in the year following injury than the GC group, controlling for age, sex, race/ethnicity, length of stay, comorbidity, injury severity, postdischarge rehabilitation, complication, and whether surgery was performed (P < .01), a difference of 0.67 ADL abilities retained by the GC group compared with the control group (95% CI, 0.06-1.4).Functional recovery for older adults following injury may be improved by GC. Early introduction of multidisciplinary care in geriatric trauma patients warrants further investigation.
Propranolol in hypertension: a dose-response study.
Authors: D B Galloway, S C Glover, W G Hendry, A W Logie, J C Petrie, M C Smith, J A Lewis, W T Simpson
Journal: BMJ (1976)

The effect of propranolol was studied in a double-blind crossover trial in 24 carefully selected hypertensive outpatients. Each patient received propranolol 60 mg/day, 120 mg/day, 240 mg/day, and placebo for four weeks each according to a randomised sequence. Propranolol 60 mg/day was no better than placebo in reducing blood pressure. The effects of propranolol 120 mg/day and 240 mg/day were not significantly different. Both doses reduced lying blood pressure by about 20/10 mm Hg from an initial level of 173/104 mm Hg. No difference was detected between the effects of the different doses of propranolol and placebo on weight or on the occurrence of adverse reactions.
Obesity and Hyperinsulinism
Authors: Thomas J. Merimee
Journal: New England Journal of Medicine (1971)

IN attempting to evolve a unitary concept to explain the metabolic and clinical aberrations of diabetes mellitus, one is hard put to find a single defect that will satisfy all the known facts. Although there is widespread support for the pancreatic beta cell as the site of the defect of this disease, a scan of the literature indicates an impressive counterattack by those nominating the liver for this dubious honor.An analogous situation applies to our understanding of what is probably the most prevalent metabolic disorder of the age — simple obesity. After the development of immunoassay methods for measuring . . .
Getting back into medicine
Authors: P. Cox
Journal: BMJ (2003)

Over 16 years ago I walked away from my first and last senior house officer post and into a very different career as a church minister. My husband and I had accepted an offer to train together, and I welcomed the chance to develop a more holistic approach to serving my fellow man. In the wake of much consternation from family and friends, I thought I might return after some months or possibly a few years. I kept my stethoscope, ophthalmoscope, and tourniquet at the back of my underwear drawer… just in case.

Well, the years have rolled by. I've had two children who are now teenagers. I've worked in numerous places around England, travelled abroad, and helped build churches in several different settings. I've been a consumer …
P118 P2×4 IMPACTS BILIARY HOMEOSTASIS AND INFLAMMATORY RESPONSE AFTER PARTIAL HEPATECTOMY IN MICE
Authors: A. Besnard, B. Julien, N. Péan, I. Garcin, E. Gonzales, I. Doignon, D. Cassio, B. Grosse, C. Housset, B. Liu, S. Branchereau, H. Safya, L. Humbert, D. Rainteau, T. Tordjmann
Journal: Journal of Hepatology (2014)
Long-Term Monitoring of Transplanted Islets Using Positron Emission Tomography
Authors: Yuxin Lu, Hoa Dang, Blake Middleton, Martha Campbell-Thompson, Mark A. Atkinson, Sanjiv Sam Gambhir, Jide Tian, Daniel L. Kaufman
Journal: Molecular Therapy (2006)

Islet transplantation can restore glucose homeostasis in those with type 1 diabetes; however, most recipients eventually lose graft function. A noninvasive method to monitor islets following transplantation would enable assessment of their survival and aid the development of therapeutics to prolong graft survival. Here, we show that recombinant lentivirus can be used to engineer human islets to express a positron emission tomography (PET) reporter gene. Following transplantation into mice, transduced islets could be imaged in vivo using microPET and a radiolabeled probe approved by the FDA for clinical use in humans. The magnitude of signal from engineered islets implanted into the axillary cavity reflected the implanted islet mass. Signals from implanted islets decreased by approximately one-half during the first few weeks following transplantation, which may reflect islet cell death shortly after transplantation. Thereafter, the magnitude of signals from the implanted islets remained fairly constant when the recipients were repetitively reimaged over 90 days. Histological analysis of the implants showed healthy islets with PET reporter-expressing cells distributed throughout the islet architecture. These studies suggest that PET imaging of lentivirus-transduced islets could provide a safe and feasible method for long-term monitoring of islet graft survival.
Danazol-induced cystitis: An undescribed source of hematuria in patients with hereditary angioneurotic edemaAndriole GL, Brickman C, Lack EE, Sesterhenn IA, Jaradpour N, Linehan WM, Frank MM, Urol 1986;135:44
Authors: None HJF
Journal: Journal of Allergy and Clinical Immunology (1987)
Quality of Life after Traumatic Injury: A Latent Trajectory Modeling Approach
Authors: Hanspeter Moergeli, Lutz Wittmann, Ulrich Schnyder
Journal: Psychotherapy and Psychosomatics (2012)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; It is largely unknown how quality of life (QoL) changes following accidental injuries. Equally, the mechanisms underlying such changes have not yet been identified in detail. This study of injured accident survivors aimed to: (1) detect a model of change which best explains the observed course of QoL, and (2) identify potential predictor variables. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; 323 injured accident survivors were interviewed within 2 weeks of the trauma, and followed up at 6 and 12 months. Latent trajectory modeling was used to analyze the fit of three potential trajectories regarding the observed course of general QoL as measured by the Questions on Life Satisfaction questionnaire. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; The trajectory model adopting a negative square-root change fitted the observed data best, meaning that shortly after the accident, general QoL decreased strongly with diminishing negative changes occurring later on. Early and prolonged QoL impairment was largely attributable to the initial level of posttraumatic stress as measured by the Clinician-Administered PTSD Scale. To a lesser extent, depressive symptoms also predicted change in subjective QoL, while injury severity showed no direct effect; rather, its impact on QoL was mediated by initial posttraumatic stress. By contrast, reduced occupational functioning was attributable to injury severity rather than psychopathology. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; When treating injured accident survivors, clinicians should consider symptoms of posttraumatic stress and comorbid depression in order to prevent or mitigate negative changes in QoL.
Report of a Case of Pericardial Mesothelioma with Liver Metastases Responding Well to Pemetrexed and Platinum-Based Chemotherapy
Authors: D.C. Doval, Shripad B. Pande, J.B. Sharma, S.A. Rao, Neeraj Prakash, A.K. Vaid
Journal: Journal of Thoracic Oncology (2007)
Jaundice in Cirrhosis
Authors: Leslie Zieve
Journal: JAMA (1965)

Bilirubin is formed in the reticuloendothelial cells by the breakdown of hemoglobin. The sequence of events is hemoglobin → hematin → protporphyrin → biliverdin → bilirubin.<sup>1</sup>Bilirubin is released from the reticuloendothelial cells into the blood in the free or unconjugated form and travels attached to albumin or αglobulin which keep it in solution. It is not excreted by the kidneys. The liver converts bilirubin to the water-soluble form by conjugating it with glucuronide, sulfate, or other groups. In this respect the liver handles bilirubin as it does a host of other compounds that it detoxifies or solubilizes by its conjugating mechanisms. Examples are corticosteroids, estrogens, thyroxin, epinephrine, morphine, and iopanoic acid (Telepaque). About 80% of the bilirubin is conjugated with glucuronide, 10% with sulfate, and the rest with other compounds. Glucuronide conjugation is thus the most important, but not the only mechanism for solubilizing bilirubin. Bilirubin conjugates are
MRI parameters for prediction of multiple sclerosis diagnosis in children with acute CNS demyelination: a prospective national cohort study
Authors: Leonard H Verhey, Helen M Branson, Manohar M Shroff, David JA Callen, John G Sled, Sridar Narayanan, A Dessa Sadovnick, Amit Bar-Or, Douglas L Arnold, Ruth Ann Marrie, Brenda Banwell
Journal: The Lancet Neurology (2011)
HCV NS5A inhibits interferon-α signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines
Authors: Keng-Hsin Lan, Keng-Li Lan, Wei-Ping Lee, Meei-Ling Sheu, Ming-Yuan Chen, Yung-Lu Lee, Sang-Hue Yen, Full-Young Chang, Shou-Dong Lee
Journal: Journal of Hepatology (2006)
Ultrastructural Pathology of the Cell: A Text and Atlas of Physiological and Pathological Alterations in Cell Fine Structure
Authors: David Lagunoff
Journal: JAMA (1976)

The electron microscope has profoundly altered the science of pathology. The instrument and the necessary associated technology have brought to view those cell structures that before had been seen dimly, erroneously, or not at all. Hydropic degeneration appears under the electron microscope variously as the swelling of the endoplasmic reticulum, mitochondria, lysosomes, or the cell sap. Senile plaques, alcoholic hyalin, and amyloid deposits can be resolved into their filamentous components. Microtubules, microfilaments, and cell junctions are visualized in pathologic reactions. While electron microscopy is not routine in surgical pathology, its use is widespread, particularly for renal and hepatic biopsies, and expanding. Ghadially has made a valiant effort to create an atlas of ultrastructural pathology. His major objective is a compendium to which the pathologist, confronted with an unfamiliar alteration in his electron micrographs, can turn to initiate his inquiry. Unfortunately, the scope of ultrastructural pathology already demands an encyclopedia. Ghadially's
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
Authors: Robert M Plenge, Chris Cotsapas, Leela Davies, Alkes L Price, Paul I W de Bakker, Julian Maller, Itsik Pe'er, Noel P Burtt, Brendan Blumenstiel, Matt DeFelice, Melissa Parkin, Rachel Barry, Wendy Winslow, Claire Healy, Robert R Graham, Benjamin M Neale, Elena Izmailova, Ronenn Roubenoff, Alexander N Parker, Roberta Glass, Elizabeth W Karlson, Nancy Maher, David A Hafler, David M Lee, Michael F Seldin, Elaine F Remmers, Annette T Lee, Leonid Padyukov, Lars Alfredsson, Jonathan Coblyn, Michael E Weinblatt, Stacey B Gabriel, Shaun Purcell, Lars Klareskog, Peter K Gregersen, Nancy A Shadick, Mark J Daly, David Altshuler
Journal: Nature Genetics (2007)
Mucosal reactive oxygen species production in oesophagitis and Barrett's oesophagus.
Authors: M Olyaee, S Sontag, W Salman, T Schnell, S Mobarhan, D Eiznhamer, A Keshavarzian
Journal: Gut (1995)

Reactive oxygen species (ROS) produced by inflammatory cells can contribute to tissue destruction. ROS have been implicated in various gastrointestinal abnormalities, including the acid related peptic diseases. Although the development of oesophagitis and Barrett's columnar epithelium is associated with prolonged reflux of gastric acid, the exact mechanism by which tissue damage occurs is not known. To discover if ROS are involved in damage to the oesophageal mucosa, this study measured in vitro the mucosal ROS concentrations of biopsied mucosal samples taken from patients with reflux oesophagitis using luminol enhanced chemiluminescence (LECL). Mucosal biopsy specimens were taken from 83 patients: 19 with normal oesophageal mucosa (group I); 20 with macroscopic oesophagitis (group II); 20 with biopsy confirmed Barrett's epithelium without macroscopic oesophagitis (group III); and 24 with Barrett's epithelium with macroscopic oesophagitis (group IV). The mucosa from patients exhibited significantly higher LECL values than the mucosa from controls. But, there were no significant differences between groups II, III, and IV. Addition of the myeloperoxidase inhibitor, azide, or the hydrogen peroxide scavenger, catalase, to the tissue suspension caused a decrease in LECL values of 32% and 45%, respectively, suggesting that neutrophils--although important--are not the only source of mucosal LECL. These data are consistent with the proposal that ROS play an important part in the tissue injury associated with oesophagitis and Barrett's columnar epithelium.