tbuckley/cabot-search huggingface dataset:
Determination of anthralin and related compounds as coloured titanium complexes
Authors: K.K. MUSTAKALLIO, J. HALMEKOSKI, S. LANKINEN
Journal: British Journal of Dermatology (1981)

Journal Article Determination of anthralin and related compounds as coloured titanium complexes Get access K.K. MUSTAKALLIO, K.K. MUSTAKALLIO Departments of Dermatology and Pharmaceutical Chemistry, Helsinki University, Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar J. HALMEKOSKI, J. HALMEKOSKI Departments of Dermatology and Pharmaceutical Chemistry, Helsinki University, Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar S. LANKINEN S. LANKINEN Departments of Dermatology and Pharmaceutical Chemistry, Helsinki University, Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s20, 1 August 1981, Page 53, https://doi.org/10.1111/j.1365-2133.1981.tb01004.x Published: 01 August 1981
The Doctor and His Bag
Authors: D. Blend
Journal: BMJ (1965)

<h3>Abstract</h3> <i>Salmonella enterica</i> serovar Enteritidis (SE), the most commonly reported serovar of human salmonellosis, has been frequently associated with poultry farms, eggs and egg products. Mice are known vectors of SE contamination in these facilities. The objective of this study was to use whole-genome sequencing (WGS) to analyze SE from mice obtained at poultry farms in Pennsylvania. Documenting pathogen diversity can identify reliable biomarkers for rapid detection and speed up outbreak investigations. We sequenced 91 SE isolates from 83 mice (62 spleen isolates, 29 intestinal isolates) caught at 15 poultry farms between 1995-1998 using an Illumina NextSeq 500. We identified 742 single nucleotide polymorphisms (SNPs) capable of distinguishing each isolate from one another. Isolates were divided into two major clades: there were more SNPs differences within Clade B than counterparts in Clade A. All isolates containing antimicrobial resistance genes belong to Subgroup B2. Clade-defining SNPs provided biomarkers distinguishing isolates from 12 individual subgroups, which were separated by farm location or year of collection. Nonsynonymous changes from the clade-defining SNPs proffered a better understanding of possible genetic variations among these isolates. For a broader view of SE diversity, we included data from NCBI Pathogen Detection Isolates Browser, in which subgroups in Clade B formed new SNP Clusters. <h3>Importance</h3> WGS and SNPs analyses are excellent and powerful tools for investigating SE phylogenies. Identifying the evolutionary relationships among SE isolates from mouse, poultry, environmental, and clinical isolates, along with patterns of genetic diversity, advances understanding of SE and the role mice may play in SE contamination and spread among poultry population. Our data was able to identify SE isolates from different farms or years of collection. Moreover, the annotations of clade-defining SNPs provided information about possible protein functions among these SE isolates from each subgroup. Clade-defining or farm-unique biomarkers were useful for rapid detection and outbreak investigations.
ROSUVASTATIN CAN REDUCE AORTIC STIFFNESS IN HYPERCHOLESTEROLEMIC PATIENTS BY FAVORABLE HEMODYNAMIC CHANGES, INDEPENDENT OF LIPID LOWERING AND ANTI-INFLAMMATORY EFFECTS
Authors: Pyung Chun Oh, Seung Hwan Han, Jong Goo Seo, Soon Yong Suh, Kyounghoon Lee, Woong Chul Kang, Kwang Kon Koh, Taehoon Ahn
Journal: Journal of the American College of Cardiology (2013)
Abstract 2380: Detecting human circulating endothelial cells using the acoustic focusing cytometer
Authors: April Anderson, Kristi Haataja, Jolene A. Bradford
Journal: Cancer Research (2012)

Abstract Circulating endothelial cells (CECs) are mature cells shed from blood vessel walls during the natural process of endothelial cell turnover. Elevated levels of CECs have been reported in a host of pathological conditions including cardiovascular disorders, infectious diseases, immune disorders, post-transplantation analysis, and cancer. In cancer research, CECs have been suggested as a noninvasive biomarker for angiogenic activity, providing insight into tumor regrowth, resistance to chemotherapy, early recurrence and metastasis formation during or after chemotherapy. In healthy individuals, CECs are reported to be present in very low numbers: 0.01%-0.0001% of all peripheral blood mononuclear cells. Flow cytometry offers the necessary collection and analysis capabilities for detection of CECs, but is subject to numerous technical challenges. In comparison to traditional hydrodynamic-focusing cytometers, the Attune® Acoustic Focusing Cytometer, with its fast acquisition times and increased precision, overcomes the technological hurdles involved in analyzing CECs. Here we present a method for detecting human circulating endothelial cells using the Attune® Acoustic Focusing Cytometer. The method includes a number of conventional ways to improve rare event detection: a blocking step, a viability stain (SYTOX® AADvanced™ Dead Cell Stain), and the use of a dump channel to eliminate unwanted cells and decrease background fluorescence. The challenge of collecting a large enough number of events in a reasonable amount of time is met by using a collection rate of 1000 µL/min with the Attune® cytometer. This setting enables the collection of more than 4,000,000 live white blood cell (WBC) events in just 35 minutes; the acquisition time using a traditional hydrodynamic-focusing cytometer would be 10-12 times longer, close to 6 hours. Furthermore, this method delivers additional time savings by eliminating wash steps to avoid sample loss and employing a simpler sample preparation method; details and specific panels designed for both the blue/violet and blue/red Attune® cytometer configurations are outlined. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2380. doi:1538-7445.AM2012-2380
Lower oesophageal contractility as an indicator of brain death.
Authors: J M Evans
Journal: BMJ (1987)

infection will be differentiated by the absence or presence of virus specific IgG antibody in serum collected early in, or preferably before, pregnancy.The detection of infection in the first trimester, before the initial visit to the antenatal clinic, will remain difficult.The presence of virus specific IgM antibody in serum collected at the first clinic visit will suggest a maternal primary cytomegalovirus infection in the first trimester, but only if the woman lacks virus specific IgG antibody before pregnancy.Such IgM antibody will remain an insensitive marker of recurrent infection in that period of pregnancy.Hence the prospective study recommended by Dr Best will be both complex and expensive, requiring the examination of large numbers of samples of maternal urine for virus excretion.Nevertheless, further accurate knowledge of the pathogenesis of congenital cytomegalovirus infection, required to assess the potential role of vaccination in its prevention, will be obtained only in this way.
New treatment strategies in ankylosing spondylitis: Proceedings of the Ankylosing Spondylitis Workshop, Berlin, Germany, 18-19 January 2002
Authors: J Sieper, J Braun
Journal: Annals of the Rheumatic Diseases (2002)

This Annals of the Rheumatic Diseases supplement is the official Proceedings of the Ankylosing Spondylitis Workshop held in Berlin, Germany earlier this year. The workshop was a remarkable assembly of international experts on ankylosing spondylitis (AS) and the other spondyloarthropathies, organised to discuss numerous aspects of diagnosis, clinical management, and treatment of the disease. The supplement consolidates information from 26 formal presentations given by the workshop participants.

AS is a complex disease in which several years typically elapse before radiological signs permit a definite diagnosis. Thus, diagnosis is often made only after significant structural damage has occurred. Patients with severe AS can face a lifetime of pain, disability, spinal deformity, reduced functioning, and subsequently, lower quality of life. At present, treatment is aimed at relieving symptoms and improving function, but no currently approved treatment alters the natural course of the disease.

Although AS is the prototypical spondyloarthropathy (SpA), the latter term also refers to reactive arthritis, arthritis/spondylitis in inflammatory bowel disease, psoriatic arthritis/spondylitis, and undifferentiated SpA (uSpA). These diseases share the same pattern of peripheral and axial joint involvement, certain extra-articular manifestations such as anterior uveitis, association with human leucocyte antigen (HLA)-B27, and an overlapping aetiology and symptomology. The search for an effective treatment for the SpAs has been neglected until recently. Presently, there are no disease modifying treatments available, similar to the situation that existed with rheumatoid arthritis two generations ago. Current opinion holds that only non-steroidal …
Chronic atrophic perichondritis.
Authors: A K Thould, A G Stansfeld, H W Balme
Journal: Annals of the Rheumatic Diseases (1965)

Sporadic reports of this rare syndrome have appeared ever since the original observation by Jaksch-Wartenhorst (1923) but, although its varia- tions are now reasonably well-defined, there have been few clues as to its aetiology.That the syn- drome seems to be related to rheumatoid arthritis is fairly clear, however.The patient may present with a polyarthritis closely resembling rheumatoid arthritis, or with swelling and redness of the skin over the ear and nose cartilages progressing to deformity of these organs.This may be accom- panied by deafness, voice changes, dizziness, tinnitus, and involvement of the rib cage.Death is usually caused from severe respiratory obstruction and its complications due to collapse of the tracheal and laryngeal cartilages (Pearson, Kline, and Newcomer, 1960).Involvement of the myocardium has been described (Harders, 1954) and of the liver (Strobel and Siefert, 1961).A patient with most of the features of this syndrome was recently admitted to this hospital, and as there has been only one report of such a case in the British medical literature (Davies and Kelsall, 1961), we now record the second British case. Case ReportA single woman aged 64 years, admitted to St. Bartholo- mew's Hospital on February 9, 1962, had been in good health until December, 1960, when she noticed some pain and swelling in the right ankle.One year later she developed pain and swelling in the left knee, and soon afterwards the right knee became similarly involved.The arthritis soon spread to affect the metacarpophalangeal and proximal interphalangeal joints of the fingers.It was accompanied by morning stiffness.Eventually most of the peripheral joints became affected by the arthritis, although the hips were not involved.There was no history of diarrhoea, urethral discharge, inflam- mation, or dryness of the eyes and mouth.In March, 1961, she developed a skin rash on the arms and the right knee.This did not resemble psoriasis and was labelled erythema marginatum.The progressive symptoms and signs of a polyarthritis similar to rheumatoid arthritis were accompanied by weight loss of about 14 lb.There was no family history of arthritis.Examination.-Sheappeared pale and ill, with pain and swelling of the joints of the hands, knees, ankles, and shoulders closely resembling rheumatoid arthritis.A marked feature was the translucent appearance of the skin, with a cyanotic tinge overlying the extensor aspects of the joints.There were no other findings of any note at that time.
Single Physical Symptoms as Residues of an Earlier Response to Stress
Authors: IAN STEVENSON
Journal: Annals of Internal Medicine (1969)

Single physical symptoms often persist after a general reaction to stress and after the other symptoms of the general reaction have subsided. Factors that influence the site of such persisting symptoms are [1] accidents affecting a particular part of the body; [2] a state of emotional arousal in which a particular action (which persists later) occurs; [3] identification of the patient with another person having a similar symptom or the same organ affected; [4] suggestion about a particular organ or symptoms from other persons; and [5] interference of the symptom with the patient's vocation (or claims to compensation) leading to continuing attention to it. Factors influencing the persistence and location of one symptom after a general reaction to stress form only one group of the relevant causal factors in these disorders.
Abstract 4588: Polylysine linker for successful manufacturing of hydrophobic peptides
Authors: Firuz Shakoori, Archana Gangakhedkar
Journal: Cancer Research (2014)

Abstract Hydrophobic peptides are common to be used in cancer vaccinations. Hydrophobic peptides, continue to present challenges for large scale production in peptide industry. Experimental Procedures: Full sequence prepared by Solid phase Synthesis:The peptide was synthesized with Fmoc-Lys(Boc)-Wang resin by using standard Fmoc/tBu chemistry. Protecting groups used for amino acids are: tBu for Thr, Boc for Trp and Lys and Boc-Ser- OH was used as a hydrolysis-labile ester provider. Fmoc-Leu-OH was coupled on the side chain of Ser by DIC/DMAP (Amino acid/DIC/DMAP, 3/1.5/0.3 eq). The other amino acids were assembled by repetitive removal of the Fmoc protecting group by treating with 2% DBU/2% piperidine in DMF 30 minutes and coupling of protected amino acid by using DIC/HOBt/NMM (4:4:4 eq) in 180 minutes to overnight. Ninhydrin test was performed after each coupling to check the coupling efficiency. After the last coupling,resin was washed and dried, then treated with reagent K for cleavage and removal of the side chain protecting groups. Crude peptide was precipitated from cold ether and collected by filtration. Table.1 Summary of 4 synthesize results Syn. NoLinker StructurePurity of CrudeDKP deletion: Product Hydrolysis YieldOverall Yield1No Linker61.4%12.3%2(O)-Ser56.5%1:252.8%12.5%3(O)-Ac-Ser40.8%1:370.6%28.2%4HMBA78.1%&amp;lt;1:2451.0%61.2% Conclusion: American Peptide demonstrated the utility of a hydrophilic peptide ‘tail’ in purification of a hydrophobic peptide on both small (20-30 mmol) research scale and large (800 mmol) cGMP scales to provide the peptide in hundreds-of-grams quantities. The approach described allowed for both time-and cost-competitive manufacturing of this difficult peptide for clinical trials. Citation Format: Firuz Shakoori, Archana Gangakhedkar. Polylysine linker for successful manufacturing of hydrophobic peptides. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4588. doi:10.1158/1538-7445.AM2014-4588
Current concepts of pheochromocytoma
Authors: Giovanni Conzo, Daniela Pasquali, Vittorio Colantuoni, Luisa Circelli, Ernesto Tartaglia, Claudio Gambardella, Salvatore Napolitano, Claudio Mauriello, Nicola Avenia, Luigi Santini, Antonio Agostino Sinisi
Journal: International Journal of Surgery (2014)
Recurrent Glioma and Crossed Cerebellar Diaschisis in a Patient Examined With 18F-DOPA and 18F-FDG PET/CT
Authors: Ferdinando Calabria, Orazio Schillaci
Journal: Clinical Nuclear Medicine (2012)

Two years after resection of a left parietal glioma, a 46-year-old woman underwent 18F-FDG and 18F-DOPA brain PET/CT. FDG showed left parietal hypometabolism with crossed cerebellar diaschisis. No abnormally increased FDG activity was seen. 18F-DOPA PET/CT scan demonstrated focal left parietal uptake. Recurrent glioma was confirmed by surgical biopsy. 18F-DOPA may demonstrate abnormal amino acid metabolism in evaluation of recurrence of glioma.
Delayed Onset of <i>Igf2</i>-Induced Mammary Tumors in <i>Igf2r</i> Transgenic Mice
Authors: Thomas L. Wise, Dimitrina D. Pravtcheva
Journal: Cancer Research (2006)

Abstract The insulin-like growth factor-II (IGF-II) receptor (IGF2R) regulates the level or activity of numerous proteins, including factors that control growth and differentiation. Frequent loss or inactivation of this receptor in a diverse group of tumors indicates that it may act as a tumor suppressor, but it is not known which functions of this receptor are selected against in the tumors. Lysosomal targeting and degradation of the growth-promoting IGF-II has been proposed as a mechanism for the tumor suppressor effects of IGF2R. As a genetic test of this hypothesis in vivo, we have produced Igf2r transgenic mice that ubiquitously express the transgene and have crossed these mice with mice that develop mammary tumors as a consequence of Igf2 overexpression. Our findings indicate that the presence of the Igf2r transgene delays mammary tumor onset and decreases tumor multiplicity in Igf2 transgenic mice. These findings are relevant to human tumors and preneoplastic conditions accompanied by altered IGF2 expression. (Cancer Res 2006; 66(3): 1327-36)
Risk of Bleeding With 2 Doses of Dabigatran Compared With Warfarin in Older and Younger Patients With Atrial Fibrillation
Authors: John W. Eikelboom, Lars Wallentin, Stuart J. Connolly, Mike Ezekowitz, Jeff S. Healey, Jonas Oldgren, Sean Yang, Marco Alings, Scott Kaatz, Stefan H. Hohnloser, Hans-Christoph Diener, Maria Grazia Franzosi, Kurt Huber, Paul Reilly, Jeanne Varrone, Salim Yusuf
Journal: Circulation (2011)

Background— Dabigatran 150 and 110 mg twice a day and warfarin are effective for stroke prevention in atrial fibrillation. The purpose of this study was to compare their risks of bleeding in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial. Methods and Results— The RE-LY trial randomized 18 113 patients to receive dabigatran 110 or 150 mg twice a day or warfarin dose adjusted to an international normalized ratio of 2.0 to 3.0 for a median follow-up of 2.0 years. Compared with warfarin, dabigatran 110 mg twice a day was associated with a lower risk of major bleeding (2.87% versus 3.57%; P =0.002), whereas dabigatran 150 mg twice a day was associated with a similar risk of major bleeding (3.31% versus 3.57%; P =0.32). There was a significant treatment-by-age interaction, such that dabigatran 110 mg twice a day compared with warfarin was associated with a lower risk of major bleeding in patients aged &lt;75 years (1.89% versus 3.04%; P &lt;0.001) and a similar risk in those aged ≥75 years (4.43% versus 4.37%; P =0.89; P for interaction &lt;0.001), whereas dabigatran 150 mg twice a day compared with warfarin was associated with a lower risk of major bleeding in those aged &lt;75 years (2.12% versus 3.04%; P &lt;0.001) and a trend toward higher risk of major bleeding in those aged ≥75 years (5.10% versus 4.37%; P =0.07; P for interaction &lt;0.001). The interaction with age was evident for extracranial bleeding, but not for intracranial bleeding, with the risk of the latter being consistently reduced with dabigatran compared with warfarin irrespective of age. Conclusions— In patients with atrial fibrillation at risk for stroke, both doses of dabigatran compared with warfarin have lower risks of both intracranial and extracranial bleeding in patients aged &lt;75 years. In those aged ≥75 years, intracranial bleeding risk is lower but extracranial bleeding risk is similar or higher with both doses of dabigatran compared with warfarin. Clinical Trial Registration— http://www.clinicaltrials.gov . Unique identifier: NCT00262600.
lndium-111 White Blood Cell Imaging
Authors: MICHAEL S. KIPPER, RICHARD J. WILLIAMS
Journal: Clinical Nuclear Medicine (1983)

Since the pioneer work of Thakur et al, in 1975, ln–111 labeled leukocyte imaging has evolved into a practical, highly accurate method for the identification of occult infection. Modifications of the labeling technique have improved efficiency as well as reduced labeling time. Virtually any nuclear medicine department can become proficient in cell labeling in a short time. A body of literature has grown in support of early claims of superiority over Ga–67 citrate. The white cell scan carries a sensitivity, specificity, and accuracy of greater than 90%. lndium–111 is well suited for external imaging (173 keV + 247 keV) and has a desirable half life of 67 hours. Images are significantly easier to interpret than gallium, testing is generally complete in 24 hours, and the cost is acceptable. The major advantage over gallium appears to be a greater specificity. Additionally there is lack of bowel excretion and no patient preparation is required. In addition to its proven efficacy in localizing occult abdominal and pelvic abscesses, preliminary reports are encouraging with respect to renal disease, inflammatory bowel disease, infected vs non-infected cysts, graft infections, and a host of other inflammatory conditions.
AN OPEN ASSESSMENT OF LOMUDAL® (DISODIUM CROMOGLYCATE) (2 PER CENT) NASAL SPRAY IN SEASONAL ALLERGIC RHINITIS
Authors: THORVALD LÖFKVIST, GUNNAR SVENSSON
Journal: Allergy (1975)

The effect of Disodium cromoglycate (Lomudal, Intal) on allergic rhinitis, given as a solution in a nasal spray, was studied in 23 adult volunteers with grass pollen allergy, none of whom were having hyposensitization therapy. The trial was carried out as an open assessment during the months of June and July, 1972. Two squirts (1.6 mg D.S.C.G.) from the nasal spray were applied to each nostril every 3 h throughout the day. In 80 per cent of subjects the treatment was successful. No side effects were noted, but five patients expressed a preference for a preparation that could be administered at less frequent intervals.
Reduced Mortality and Strokes With Off-Pump Coronary Artery Bypass Grafting Surgery in Octogenarians
Authors: Roland G. Demaria, Michel Carrier, Simon Fortier, Raymond Martineau, Annick Fortier, Raymond Cartier, Michel Pellerin, Yves Hébert, Denis Bouchard, Pierre Pagé, Louis P. Perrault
Journal: Circulation (2002)

Off-pump coronary artery bypass surgery (OPCAB) has been revived and has gained popularity, although the exact subsets of patients who might benefit most from this technique are unknown. The aim of this retrospective study was to compare the results of coronary artery bypass grafting surgery (CABG) in octogenarians using cardiopulmonary bypass (CPB) or OPCAB techniques.Over a 5-year period (1995-1999), 125 patients older than 80 years of age were operated for isolated myocardial revascularization (63 using CPB and 62 with OPCAB). There was no statistically significant difference in preoperative comorbidities between groups or in mean left ventricular ejection fraction (54.5+/-15.3% in the CPB group and 50.9+/-13.5% in the OPCAB group, respectively). The mean number of distal anastomosis per patient was 2.9 in CPB group and 2.6 in OPCAB group (P=ns). The majority of patients in both groups had unstable angina and were operated on an urgent basis. The operative mortality was 15.9% in the CPB group and 4.8% in the OPCAB group (P=0.04). There were 4 postoperative strokes (6.3%) in the CPB group and none (0%) in the OPCAB group (P=0.04). The percentage of patients transfused was 92.1% in the CPB group and 72.6% in the OPCAB group (P<0.01). Postoperative myocardial infarction occurred in 11.3% in the CPB group and 14.5% in the OPCAB group (P=NS). For all the parameters entered in the multivariate analysis with logistic regression model, the type of surgery (CPB or OPCAB) was an independent predictor of operative mortality and stroke (P=0.0375). The odds ratio (OR) indicates that operative mortality and stroke occur 4 times (OR=4.171) more often in CPB patients than in OPCAB patients. Follow-up showed no significant difference between the 2 groups in terms of cardiac events and mortality.This retrospective study suggests a benefit of OPCAB in terms of operative mortality and stroke for octogenarian patients when compared with CPB in our institution.