tbuckley/cabot-search huggingface dataset:
Connective Tissue Activation: The Presence of Connective-Tissue-Activating Peptide in Plasma and Synovial Fluid.
Authors: John R. Horn
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Connective Tissue Activation: The Presence of Connective-Tissue-Activating Peptide in Plasma and Synovial Fluid.John R. Horn, M.D., C. William Castor, M.D., F.A.C.P.John R. Horn, M.D.Search for more papers by this author, C. William Castor, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-881_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA connective-tissue-activating peptide (CTAP) extracted from human cells stimulated the metabolism of synovial fibroblasts in a manner resembling rheumatoid synovitis. Metabolic changes included increased hyaluronate and lactic acid production and glucose consumption. Since CTAP had not previously been described in body fluids, plasma and joint fluid collected from patients with various rheumatic diseases was examined. Plasma or joint fluid was chromatographed on Sephadex G-50 (fine) columns. Connective-tissue-activating peptide purified from human spleen could be isolated from these columns at the same elution position used for the plasma and joint fluid samples. The joint fluid was incubated with hyaluronidase before chromatography.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySYNOVIAL CELL ACTIVATION INDUCED BY A POLYPEPTIDE MEDIATOR 1 May 1972Volume 76, Issue 5Page: 881-881KeywordsBlood plasmaCell metabolismCellsChromatographyConnective tissueFibroblastsGlucoseLactic acidSpleenSynovial fluid Issue Published: 1 May 1972 PDF DownloadLoading ...
20 LOSARTAN ALONE OR COMBINED WITH SIMVASTATIN IMPROVED VISCERAL ADIPOSE TISSUE AND INFLAMMATION IN HYPERTENSIVE NORMOCHOLESTEROLEMIC PATIENTS WITH NON-ALCOHOLIC HEPATIC STEATOSIS
Authors: R. Fogari, A. Mugellini, A. Zoppi, P. Lazzari, P. Maffioli, G. Derosa
Journal: Journal of Hepatology (2011)
Vaccination of a Patient Receiving Immunosuppressive Therapy for Lymphosarcoma
Authors: Ernest H. Rosenbaum
Journal: JAMA (1966)

Generalized vaccinia developed in a patient with lymphosarcoma and hypogammaglobulinemia who was receiving prednisone therapy. Experimental studies with guinea pigs receiving immunosuppressive drugs followed by vaccination were undertaken. Corticosteroids, alkylating agents, antimetabolites, and x-ray therapy may suppress the host's immunological response to infection. Experimental results showed that guinea pigs receiving mercaptopurine and methotrexate had marked vacciniallike lesions following vaccination. Smallpox vaccination may be contraindicated in patients who are receiving immunosuppressive agents, ie, mercaptopurine and methotrexate, for treatment of collagen, neoplastic, and autoimmune disease as well as for organ transplantations. Vaccination of such patients may be followed by vaccinia gangrenosa, generalized vaccinia, or death.
Physiology of Respiration: An Introductory Text
Authors: David W. Cugell
Journal: JAMA (1965)

This book, one of a series on organ physiology, complements a previous text by Dr. Comroe and others entitled<i>The Lung</i>. The earlier book dealt primarily with the background and techniques used in clinical physiology laboratories to evaluate pulmonary function, and included 17 case presentations illustrative of clinical applications. This new publication is organized in the customary manner of a physiology text. There are separate chapters on central nervous system regulation of respiration, pulmonary and other reflexes, the response to excess and deficits of both oxygen and carbon dioxide, and a review of the functions of the upper respiratory tract. The bulk of the text is devoted to the clinically more familiar aspects of lung function—ventilation, lung volumes, mechanical factors in breathing, pulmonary circulation, and gas transport, plus a brief section entitled "Manifestations of Pulmonary Disease," containing physiological explanations of common symptomatology. Dr. Comroe has a justly deserved reputation for
Chickenpox vaccine may reduce risk of shingles
Authors: D. Spurgeon
Journal: BMJ (2002)

Stanford University researchers have found that giving an inactivated form of chickenpox vaccine to adults can reduce the risk of herpes zoster (shingles), which strikes elderly people and people with weakened immune systems.

Even among healthy adults the risk of shingles rises each decade after age 60, increasing to one in five people in their …
Reliability of routine double contrast examination of the large bowel: a prospective study of 2590 patients.
Authors: F T Fork
Journal: Gut (1983)

A total of 2590 consecutive patients referred for double contrast examination (DCE) of the large bowel were followed up radiographically, clinically, endoscopically, and histopathologically during a four year period. The patients were put into two groups on the basis of the presence or absence of radiographic evidence of colonic disease at the first--that is, index examination. By comparing the findings obtained at the index double contrast examination with those obtained during follow up, the sensitivity, specificity, and accuracy of the index double contrast examination were all calculated at 0.84. The predictive value of a positive report was 0.93 and that of a negative report 0.70. If, however, patients with normal double contrast examinations at the start of this series and not examined further during the follow up period were accepted as free from significant colonic disease, the predictive value of a negative report increased to 0.93. Double contrast examination is thus a reliable method for showing the presence of colonic lesions and therefore considerably helps the management of a given case.
CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV–1 strains in a T–cell line
Authors: Tamás Oravecz, Gregory Roderiquez, Justin Koffi, Jinhai Wang, Mary Ditto, Dumith Chequer Bou-Habib, Paolo Lusso, Michael A. Norcross
Journal: Nature Medicine (1995)
Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12
Authors: Miguel Barajas, Guillermo Mazzolini, Guillem Genové, Roberto Bilbao, Iñigo Narvaiza, Volker Schmitz, Bruno Sangro, Ignacio Melero, Cheng Qian, Jesús Prieto
Journal: Hepatology (2001)

The use of gene therapy to enhance antitumor immunity has emerged as a promising procedure to fight cancer. In this study we have tested the ability of an adenovirus carrying interleukin 12 (IL–12) gene (AdCMVIL–12) to eliminate tumoral lesions in 3 animal models of orthotopic hepatocellular carcinoma (HCC). Intratumoral injection of AdCMVIL–12 in animals with a single big tumor nodule implanted in the liver resulted in significant inhibition of tumor growth in a dose–dependent manner. Fifty percent of animals that received a dose of 5 × 10 9 plaque–forming units, showed complete regression of the tumor 2 weeks after treatment. In animals with 2 independent tumor nodules in the left liver lobe, injection in only one of them of 5 × 10 9 pfu AdCMVIL–12 induced, 15 days after therapy, complete regression of 50% of treated tumors and also of 50% of untreated lesions, with 60% long–term survival. Rats that were tumor free after therapy with AdCMVIL–12 showed protection against tumor rechallenge. A group of rats received the carcinogen diethylnitrosamine and developed multiple hepatic dysplasic nodules of 1 to 5 mm in diameter. These animals were treated by intrahepatic artery injection of either AdCMVIL–12 (5 × 10 9 pfu) or control vector. In this model AdCMVIL–12 induced complete tumor regression in 20% of treated rats and inhibited tumor growth in 60% of cases with an increase in rat survival. Activation of natural killer (NK) cells and inhibition of angiogenesis were found to be antitumor mechanisms set in motion by AdCMVIL–12. Our data indicate that experimental HCC can be efficiently treated by intratumoral or intravascular injection of adenovirus expressing IL–12.
Colonoscopic surveillance in ulcerative colitis--dysplasia through the looking glass.
Authors: J B Fozard, M F Dixon
Journal: Gut (1989)

Leading articleColonoscopic surveillance in ulcerative colitisdysplasia through the looking glass Reflection Carcinoma was first described as a complication of ulcerative colitis (UC) by Crohn and Rosenberg in 1925.' Since then many workers have attempted to quantify the degree of increased cancer risk associated with UC.Most early studies tended to overestimate the degree of risk, calculating cumulative cancer rates ranging from 16% to 43% depending on the duration of disease.2'In contrast, Hendricksen (in Denmark)' and Maratka (Czechoslovakia)6 have produced figures for cumulative risk of 1*4% and 5% at 18 and 20 years from onset respectively.The reasons for such wide discrepancies in the assessment of cancer risk have been well reviewed by Whelan7 and Lennard-Jones.iThey relate to inadequate follow up, differ- ences in study populations, treatment policy and methods of analysis.More recently, in a retrospective cohort study which took these criticisms into account, Gyde et al' report cumulative risks for cancer in extensive colitis of 7.2% at 20 years and 16-5% at 30 years, while in a population based study in Israel, Gilat et al'°found an incidence of 9.3% and 13.8% at 15 and 20 years respectively for total colitis.Based on such studies two factors have emerged as being of major importance in determining cancer risk, duration and extent of disease.There is a low risk of cancer at less than 10 years duration with increasing risk thereafter.There is a much greater cancer risk in patients with total colitis than in those with left sided disease, whose risk is at or around that of the general population.9Onset of UC in childhood may be an additional risk factor4 but this has not been borne out by recent studies8' and cancer incidence standardised for duration of disease is higher in older patients.'0In the past prophylactic colectomy or proctocolectomy was advocated in patients with total UC of greater than 10 years duration.34Advances in surgical technique now mean that a permanent stoma can be avoided. 12Most patients with UC (more than 80%), however, do not develop colorectal cancer and many patients even with long standing UC are relatively young and have minimal symptoms.The alternative of endoscopic surveillance is therefore an attractive option.Dysplasia through the endoscope Precancerous changes occurring in UC were described by Dawson and Pryse-Davies in 1959'3 but it was Morson and Pang'4 who reported that dysplasia was often widespread, could occur in flat mucosa and was detectable on rectal biopsy, thereby identifying patients who had entered a 285 on August 20, 2023 by guest.
The Intravenous Use of Epinephrine in Severe Bronchial Asthma
Authors: I. S. KAHN
Journal: Annals of Internal Medicine (1930)

Article1 May 1930The Intravenous Use of Epinephrine in Severe Bronchial AsthmaI. S. KAHN, M.D.I. S. KAHN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-11-1140 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe following case report suggests that is is possible to secure complete relief in the severest possible type of bronchial asthma that apparently offers nothing but a prompt fatal outcome, by the use of epinephrine in small doses given intravenously, after the administration of the drug in large quantities hypodermatically in the ordinary manner and after morphia given to the danger point have completely failed. In this case, and in two others of mine of the same type, the procedure was a life saving measure, and it is trusted that its adoption elsewhere in similar cases will prevent protracted suffering... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: I. S. KAHN, M.D.Affiliations: San Antonio, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySubcutaneous epinephrinevs nebulized salbutamol in asthmaThe Use of Sodium Bicarbonate in the Treatment of Acute Bronchial AsthmaStatus asthmaticus 1 May 1930Volume 3, Issue 11Page: 1140-1142KeywordsAsthmaDrug administrationDrugsEpinephrineMorphine ePublished: 1 December 2008 Issue Published: 1 May 1930 PDF downloadLoading ...
Angio-edema and urticaria associated with omeprazole.
Authors: M. R. Haeney
Journal: BMJ (1992)

Cambridge CB3 8RE) write: Papa- verine administered by the intracoronary route in humans produces a brief maximal hyperaemic response in the coronary circulation that has little systemic effect and is used to measure coronary flow reserve in cardiac disease. 2 Intracoronary papaverine is known to produce changes in cardiac electrophysio- logical variables and ST-T configur- ation and prolongation of the QT interval.3Isolated cases of ventricular tachycardia and ventricular fibril- lation have also been described.46We describe a case of complete atrioven- tricular block after intracoronary papaverine administration.A 53 year old man was undergoing investigations for chest pain with a positive response on exercise electro- cardiography and normal coronary arteries on angiography.He was re- admitted for further investigations, including coronary flow reserve studies.He had been taking nifedipine for several months and this was stopped 24 hours before cardiac catheterisation.His only other medication was dipyridamole, which was continued.Baseline pulse rate, blood pressure, electrocardiogram, and serum electolyte concentrations were normal.Resting coronary blood flow was measured with a 3F 20 mHz intracoronary Doppler flow probe.Incremental doses of intracoronary papaverine were given after a 2 mg test dose.After administration of a 12 mg dose the patient developed complete atrioventricular block last- ing five seconds.He remained asymptomatic and was haemo- dynamically stable.The study was terminated because of this unexpected side effect.This case shows that, although papaverine is a relatively safe coron- ary vasodilator for measuring coron- ary flow reserve, all patients should be closely monitored while receiving intracoronary papaverine.A tem- porary pacemaker should also be available as well as appropriate antiarrhythmic preparations.1 Wilson RF, White CW.Intracoronary papa- venne: an ideal coronars vasodilator for studies of the coronary circulation in con- scious humans.
Gene Targeting of Mutant COL1A2 Alleles in Mesenchymal Stem Cells From Individuals With Osteogenesis Imperfecta
Authors: Joel R Chamberlain, David R Deyle, Ulrike Schwarze, Peirong Wang, Roli K Hirata, Yi Li, Peter H Byers, David W Russell
Journal: Molecular Therapy (2007)

Mesenchymal stem cells (MSCs) are adult cells with the capacity to differentiate into multiple cell types, including bone, fat, cartilage, and muscle cells. In order to effectively utilize autologous MSCs in cell-based therapies, precise genetic manipulations are required to eliminate the effects of disease-causing mutations. We previously used adeno-associated virus (AAV) vectors to target and inactivate mutant COL1A1 genes in MSCs from individuals with the brittle bone disorder, osteogenesis imperfecta (OI). Here we have used AAV vectors to inactivate mutant COL1A2 genes in OI MSCs, thereby demonstrating that both type I collagen genes responsible for OI can be successfully targeted. We incorporated improved vector designs so as to minimize the consequences of random integration, facilitate the removal of potential antigens, and avoid unwanted exon skipping. MSCs targeted at mutant COL1A2 alleles produced normal type I procollagen and formed bone, thereby demonstrating their therapeutic potential.
Localized Dissecting Hemorrhage and Arteritis
Authors: Gherardo J. Gherardi
Journal: JAMA (1967)

PERIARTERITIS NODOSA has been gradually redefined over the past hundred years so as to become but a phase in a broad spectrum of vascular disease in which the individual members tend to lose their identity. To most people, however, it represents a widely disseminated panarteritis with ischemic rather than primarily hemorrhagic manifestations which are characteristically not isolated. This case is presented primarily (1) because it proves distinctive and variant in its histological pattern, (2) for the isolated localization of its principal lesions, and (3) for its totally deceptive manifestations mimicking a ruptured aneurysm of a cerebral artery. <h3>Report of a Case</h3> The patient, a 26-year-old white woman, had been known to have hypertension for the last ten years and migraine headaches for many more. This last illness began suddenly with severe headache followed by unresponsiveness, nuchal rigidity, and grossly bloody spinal fluid. Her temperature was 103 F (39.4 C) on
Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms
Authors: Sangeeta Nischal, Sanchari Bhattacharyya, Maximilian Christopeit, Yiting Yu, Li Zhou, Tushar D. Bhagat, Davendra Sohal, Britta Will, Yongkai Mo, Masako Suzuki, Animesh Pardanani, Michael McDevitt, Jaroslaw P. Maciejewski, Ari M. Melnick, John M. Greally, Ulrich Steidl, Alison Moliterno, Amit Verma
Journal: Cancer Research (2012)

Even though mutations in epigenetic regulators frequently occur in myeloproliferative neoplasms, their effects on the epigenome have not been well studied. Furthermore, even though primary myelofibrosis (PMF) has a markedly worse prognosis than essential thrombocytosis or polycythemia vera, the molecular distinctions between these subgroups are not well elucidated. We conducted the HELP (HpaII tiny fragment enriched by LM-PCR) assay to study genome-wide methylation in polycythemia vera, essential thrombocytosis, and PMF samples compared with healthy controls. We determined that polycythemia vera and essential thrombocytosis are characterized by aberrant promoter hypermethylation, whereas PMF is an epigenetically distinct subgroup characterized by both aberrant hyper- and hypomethylation. Aberrant hypomethylation in PMF was seen to occur in non-CpG island loci, showing further qualitative differences between the disease subgroups. The differentially methylated genes in polycythemia vera and essential thrombocytosis were involved predominantly in cell signaling pathways and were enriched for binding sites of GATA1 and other transcription factors. In contrast, aberrantly methylated genes in PMF were involved in inflammatory pathways and were enriched for NF1, LEF1, and other transcription factors. Within the PMF subgroup, cases with ASXL1 disruptions formed an epigenetically distinct subgroup with relatively increased methylation. Cases of myeloproliferative neoplasms (MPN) with TET2 mutations showed decreased levels of hydroxymethylation and distinct set of hypermethylated genes. In contrast, the JAK2V617F mutation did not drive epigenetic clustering within MPNs. Finally, the significance of aberrant methylation was shown by sensitivity of MPN-derived cell lines to decitabine. These results show epigenetic differences between PMF and polycythemia vera/essential thrombocytosis and reveal methylomic signatures of ASXL1 and TET2 mutations.
ACTION OF THE GOLDEN BELT DISTRICT MEDICAL SOCIETY OF KANSAS.
Authors: E. C. Dudley
Journal: JAMA (1891)

<h3>To the Editor:</h3> —I have been interested in the correspondence pro and con on the proposed removal ofThe Journalfrom Chicago to Washington. Unless some very important personal interests are to be served, no tangible reason appears why the change should be made. One might have a certain National pride in the location ofThe Journalin Washington because it is the Capital of the Nation; but sentiment in such an enterprise should give way to utility. There are decided practical advantages in a great medical centre, which Washington can never have. It is a question whether the quality ofThe Journalwould be satisfactory to the whole profession if it were made subject to the political and bureaucratic influences of the Capital. As a permanent home forThe JournalChicago would improve; Washington would not. Of all the great medical centres in the country Chicago has the minimum
A medical team goes to Olympics
Authors: Phil Gunby
Journal: JAMA (1984)

Members.LTAembers of one of the best-trained American teams in Los Angeles are hoping not to see much action during the forthcoming summer Olympic Games. They are physicians of the Epidemic Intelligence Service, which has its headquarters at the Centers for Disease Control (CDC), Atlanta (<i>JAMA</i>[MEDICAL NEWS] 1979;241:2776-2782 and 1983;250:1131-1132). From now until Aug 12, when the 23rd Olympiad is scheduled to end, they are joining other public health officials in watching for what Michael B. Gregg, MD, calls "big or puzzling" changes in the health status of the hundreds of thousands of people on hand for the summer Games. Gregg, deputy director of the CDC's Epidemiology Program Office and editor of the<i>Morbidity and Mortality Weekly Report</i>, says the surveillance is being carried out in close cooperation with state and local health officials and that a key ingredient is "a first-rate communications system." Physicians of the Epidemic Intelligence Service—usually
Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin
Authors: C.A. Harwood, T. Surentheran, P. Sasieni, C.M. Proby, C. Bordea, I.M. Leigh, F. Wojnarowska, J. Breuer, J.M. Mcgregor
Journal: British Journal of Dermatology (2004)

Human papillomaviruses (HPVs) are found in normal skin and in benign and malignant skin conditions. Epidermodysplasia verruciformis (EV) HPV types are those most plausibly linked to the development of squamous cell carcinomas of the skin.To assess the risk of nonmelanoma skin cancer (NMSC) associated with the presence of EV HPV in normal skin in immunocompetent (IC) individuals and renal transplant recipients (RTRs).Using a degenerate and nested polymerase chain reaction technique, HPV DNA was sought in 124 normal skin samples from sun-exposed and nonsun-exposed sites, from 39 IC individuals and 38 RTRs, both with and without NMSC. Data were analysed using the Mantel-Haenszel test and by logistic regression analysis.HPV DNA was detected in 58/67 (87%) and 20/57 (35%) samples from renal transplant and IC patients, respectively. There was no difference in either the prevalence or spectrum of HPV types found in sun-exposed and nonsun-exposed normal skin. However, there was significant association between NMSC and the presence of EV HPV DNA. Multivariate analysis provided an odds ratio of 6.41 (95% confidence interval 1.79-22.9) for the association of EV HPV DNA in normal skin (irrespective of site) and NMSC status, even after stratifying for patient group and adjusting for the clustering effect of multiple sampling. Conversely, there was no association between skin cancer status and the presence of cutaneous or mucosal HPV types in either sun-exposed or nonsun-exposed skin.HPV DNA is widespread in normal adult skin, particularly in transplant patients. In our study, the presence of EV but not cutaneous HPV DNA in normal skin was significantly associated with NMSC status and may prove to be of predictive value for skin cancer risk. These data provide reason to focus on EV HPV types as causal agents in skin cancer.
Complications of Gynecologic Laparoscopic Surgery -- A French Multicenter Collaborative Study
Authors: Denis Querleu, Charles Chapron, Luc Chevallier, Maurice A. Bruhat
Journal: New England Journal of Medicine (1993)

To the Editor: Despite the growth of laparoscopic surgery, its complications must not be underestimated. We describe a retrospective (1987 to 1989) and prospective (1990 to 1991) study of the compl...