Putting Some Muscle into Osteoarthritis
Authors: Kenneth D. Brandt
Journal: Annals of Internal Medicine (1997)

Editorials15 July 1997Putting Some Muscle into OsteoarthritisKenneth D. Brandt, MDKenneth D. Brandt, MDIndiana University School of Medicine Indianapolis, IN 46202-5103Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Osteoarthritis, the most common joint disease, results from the complex interplay of biochemical, metabolic, and biomechanical factors and is characterized, in part, by the progressive loss of articular cartilage. Aggrecan and collagen, the major molecular constituents of articular cartilage, confer stiffness on compression and tensile strength, respectively. Evidence that the metabolic turnover rates of these molecules are increased in osteoarthritic cartilage has led investigators to search for enzymes responsible for their degradation in the hope that pharmacologic inhibitors might be developed to prevent the development or slow the progression of osteoarthritis.In vitro, several matrix metalloproteinases (MMPs) degrade the core ...References1. Fosang AJ, Last K, Maciewicz RA. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metailoproteinase and aggrecanase activities can be independent. J Clin Invest. 1996; 98:2292-9. Google Scholar2. Arner EC, Decicco CP, Pratta MA, Copeland RA, Trzaskos JM, Magolda RL, et al. Characterization of soluble bovine cartilage “aggrecanase” [Abstract]. Transactions of the Orthopaedic Research Society. 1997; 22:103. Google Scholar3. Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier J. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest. 1996; 97:2011-9. Google Scholar4. Smith GN, Hasty KA, Mickler EA, Brandt KD. Specificity of doxycycline inhibition of MMPs: relation to MMP structure [Abstract]. Transactions of the Orthopaedic Research Society. 1997; 22:105. Google Scholar5. Yu LP Jr, Smith GN Jr, Brandt KD, Myers SL, O'Connor BL, Brandt DA. Reduction of the severity of the canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthritis Rheum. 1992; 35:1150-9. Google Scholar6. Smith GN Jr, Brandt KD, Hasty KA. Activation of recombinant human neutrophil procollagenase in the presence of doxycycline results in fragmentation of the enzyme and loss of enzyme activity. Arthritis Rheum. 1996; 39:235-44. Google Scholar7. Amin AR, Attur MG, Thakker GD, Patel PD, Vyes PR, Patel RN, et al. A novel mechanism of action of tetracyclines: effects on nitric oxide synthases Proc Natl Acad Sci U S A. 1996; 93:14014-9. Google Scholar8. Murrell GA, Jang D. Williams RJ. Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochem Biophys Res Commun. 1995; 206:15-21. Google Scholar9. Vilensky J, O'Connor B, Brandt K, Dunn E, Rogers P. Serial kinematic analysis of the canine hind limb joints after deafferentation and anterior cruciate ligament transection. Osteoarthritis and Cartilage. 1997; 5:173-82. Google Scholar10. Sharma L, Pai Y. The relationship between impaired proprioception and osteoarthritis. Curr Opin Rheumatol. 1997; 9:253-8. Google Scholar11. Fisher NM, Kame VD Jr, Rouse L, Pendergast DR. Quantitative evaluation of a home exercise program on muscle and functional capacity of patients with osteoarthritis. Am J Phys Med Rehabil. 1994; 3:413-20. Google Scholar12. Hurley MV, Newham DJ. The influence of arthrogenous muscle inhibition on quadriceps rehabilitation of patients with early, unilateral osteoarthritic knees. Br J Rheumatol. 1993; 32:127-31. Google Scholar13. Hurwitz D, Sum J, Andriacchi TP, Schnitzer TJ, Andersson G. The effects of osteoarthritis knee pain on joint loading [Abstract]. Transactions of the Orthopaedic Research Society. 1997; 22:723. Google Scholar14. Palmoski MJ, Brandt KD. Effects of some nonsteroidal antiinflammatory drugs on proteoglycan metabolism and organization in canine articular cartilage. Arthritis Rheum. 1980; 23:1010-20. Google Scholar15. Radin EL, Boyd RD, Martin RB, Burr DB, Caterson B, Goodwin C. Mechanical factors influencing cartilage damage. In: Peyron JG, ed. Osteoarthritis: Current Clinical and Fundamental Problems. Paris: Geigy; 1985:90-9. Google Scholar16. Hill AV. Production and absorption of work by muscle. Science. 1960; 131:897-903. Google Scholar17. Jefferson RJ, Collins JJ, Whittle MW, Radin EL, O'Connor JJ. The role of the quadriceps in controlling impulsive forces around heel strike. Proc Inst Mech Eng [H]. 1990; 204:21-8. Google Scholar18. Radin EL, Yang KH, Riegger C, Kish VL, O'Connor JJ. Relationship between lower limb dynamics and knee joint pain. J Orthop Res. 1991; 9:398-405. Google Scholar19. Mikesky AE, Topp R, Wigglesworth JK, Harsha DM, Edwards JE. Efficacy of a home-based training program for older adults using elastic tubing Eur J Appl Physiol. 1994; 69:316-20. Google Scholar Author, Article, and Disclosure InformationAffiliations: Indiana University School of Medicine Indianapolis, IN 46202-5103Acknowledgment: The author thanks Kathie Lane for expert secretarial assistance.Grant Support: In part by grants AR20582 and AR43348 from the National Institutes of Health.Corresponding Author: Kenneth D. Brandt, MD, Rheumatology Division, 541 Clinical Drive, Room 492, Indianapolis, IN 46202. 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