The New Fluorinated Quinolones for Infection Prevention in Acute Leukemia
Authors: LOWELL S. YOUNG
Journal: Annals of Internal Medicine (1987)

Editorials1 January 1987The New Fluorinated Quinolones for Infection Prevention in Acute LeukemiaLOWELL S. YOUNG, M.D.LOWELL S. YOUNG, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-1-144 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevention of bacterial infection has been a major goal of antileukemic therapy ever since it was recognized that cytotoxic and immunosuppressive agents strongly predispose neutropenic patients to acute bacteremia (1). The first efforts at antimicrobial and immunologic prophylaxis, however, were notably unsuccessful. Tetracyclines were initially used as oral prophylactic agents, but no success could be clearly shown (2). Two decades ago, gammaglobulin pooled from human sources by standard Cohn fractionation techniques was given to patients with acute leukemia and failed to influence the incidence or course of infection (3). More recently, use of prophylactic granulocyte transfusions appeared to lower the...References1. YOUNG L. Management of infections in leukemia and lymphoma. In: RUBIN RH, YOUNG LS, eds. The Clinical Approach to Infection in the Compromised Host. New York: Plenum Press; 1981:461-506. Google Scholar2. BOGGSFREIZIERDT DEC. Fever in malignant neoplastic disease: a controlled study of tetracycline therapy. Ann Intern Med. 1960;53:754-64. LinkGoogle Scholar3. BODEYNIESMOHBERGFREIREICH GBNE. Use of gamma globulin in infection in acute leukemia patients. JAMA. 1964;190:1099-102. CrossrefMedlineGoogle Scholar4. CLIFTSANDERSTHOMASWILLIAMSBUCKNER RJEBC. Granulocyte transfusions for the prevention of infection in patients receiving bone-marrow transplants. N Engl J Med. 1978;298:1052-7. CrossrefMedlineGoogle Scholar5. STRAUSSCONNETTGALE RJR. A controlled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogenous leukemia. N Engl J Med. 1981;305:597-603. CrossrefMedlineGoogle Scholar6. YOUNG L. Prophylactic granulocytes in the neutropenic host. Ann Intern Med. 1982;96:240-2. LinkGoogle Scholar7. YOUNG L. The role of granulocyte transfusions in treating and preventing infection. Cancer Treat Rep. 1983;67:109-11. MedlineGoogle Scholar8. HUGHESKUHNCHAUDHARY WSS. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1977;297:1419-26. CrossrefMedlineGoogle Scholar9. WADEDE JONGHNEWMANCROWLEYWIERNIKSCHIMPFF JCKJPS. Selective antimicrobial modulation as prophylaxis against infection during granulocytopenia: trimethoprim-sulfamethoxazole vs. nalidixic acid. J Infect Dis. 1983;147:624-34. CrossrefMedlineGoogle Scholar10. KRAMERCARRRAND BDK. Prophylaxis of fever and infection in adult cancer patients: a placebo-controlled trial of oral trimethoprim-sulfamethoxazole plus erythromycin. Cancer. 1984;53:329-35. CrossrefMedlineGoogle Scholar11. WELLSPODZORSKIPETERSONRAMSAYSIMMONSRHAME CRPNRF. Incidence of trimethoprim-sulfamethoxazole-resistant Enterobacteriaceae among transplant recipients. J Infect Dis. 1984;150:699-706. CrossrefMedlineGoogle Scholar12. PIZZOROBICHAUDEDWARDSSCHUMAKERKRAMERJOHNSON PKBCBA. Oral antibiotic prophylaxis in patients with cancer: a double-blind, randomized placebo-controlled trial. J Pediatr. 1983;102:125-33. CrossrefMedlineGoogle Scholar13. GUIOTVANMEERVAN FURTH HDJR. Selective antimicrobial modulation of human microbial flora: infection prevention in patients with decreased host defense mechanisms by selective elimination of potentially pathogenic bacteria. J Infect Dis. 1981;143:644-54. CrossrefMedlineGoogle Scholar14. VAN DER WAAIJBERGHUIS DJ. Determination of the colonization resistance of the digestive tract of individual mice. J Hyg (Camb). 1974;72:379-87. CrossrefMedlineGoogle Scholar15. GUIOT H. Role of competition for substrate in bacterial antagonism in the gut. Infect Immun. 1982;38:887-92. CrossrefMedlineGoogle Scholar16. YOUNG L. Nosocomial infections in the immunocompromised adult. Am J Med. 1981;70:398-404. CrossrefMedlineGoogle Scholar17. YOUNG L. Trimethoprim-sulfamethoxazole and bacterial infections during leukemia therapy [Editorial]. Ann Intern Med. 1981;95:508-9. LinkGoogle Scholar18. YOUNG L. Antimicrobial prophylaxis against infection in neutropenic patients. J Infect Dis. 1983;147:611-4. CrossrefMedlineGoogle Scholar19. DEKKERROZENBERG-ARSKASIXMAVERHOEF AMJJ. Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia. Ann Intern Med. 1981;95:555-9. LinkGoogle Scholar20. DEKKERROZENBERG-ARSKAVERHOEF AMJ. Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. Ann Intern Med. 1987;106:7-12. LinkGoogle Scholar21. KARPMERZHENDRICKSEN JWC. Oral norfloxacin for prevention of gram-negative bacterial infections in patients with acute leukemia and granulocytopenia: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1987;106:1-7. LinkGoogle Scholar22. SCULLYNEUPARRYMANDELL BHMW. Oral ciprofloxacin therapy of infections due to Pseudomonas aeruginosa. Lancet. 1986;1:819-22. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LOWELL S. YOUNG, M.D.Affiliations: Kuzell Institute for Arthritis and Infectious Diseases Pacific Presbyterian Medical Center San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byManagement of fever and neutropenia in the adult patient with acute myeloid leukemiaManagement of Infections in Leukemia and LymphomaOral ciprofloxacin plus colistin: prophylaxis against bacterial infection in neutropenic patients. 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DUMA, M.D., Ph.D. 1 January 1987Volume 106, Issue 1Page: 144-146KeywordsAntimicrobialsBacteremiaChemical fractionationGranulocytesImmunosuppressivesProphylaxisTetracyclines ePublished: 1 December 2008 Issue Published: 1 January 1987 PDF downloadLoading ...