tbuckley/cabot-search huggingface dataset:
Utility of Bladder Lavage in Meckel??s Scanning
Authors: FREDERICK L. DATZ, ANDREW TAYLOR
Journal: Clinical Nuclear Medicine (1985)

Accumulation of radioactive urine in a bladder diverticulum on a Tc-99m pertechnetate scan simulated uptake in a Meckel's diverticulum. The abnormal activity was present even following bladder catheterization and drainage. However, saline lavage washed the residual activity out of the bladder, and prevented a false-positive diagnosis. In addition to preventing false-positive studies, bladder lavage may increase the sensitivity of the test by allowing the detection of Meckel's diverticuli that are obscured by residual bladder activity.
Chief hospital inspector defends scrutiny system
Authors: G. Iacobucci
Journal: BMJ (2014)

England’s chief inspector of hospitals, Mike Richards, has issued a robust defence of healthcare inspections after a prominent health commentator labelled them a waste of money that led to problems being covered up in the NHS.

In a debate at the Health and Care Innovation Expo in Manchester on 3 March, Richards insisted that the new inspection regime by the Care Quality Commission (CQC) would raise quality and highlight good performance, as well as rooting out poor care in the system. …
Cephalothin Therapy and Meningitis
Authors: JOEL SPALTER
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 December 1973Cephalothin Therapy and MeningitisJOEL SPALTER, M.D.JOEL SPALTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-6-911 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The development of meningitis during cephalothin therapy was recently described in your journal (Ann Intern Med 78:347-351, 1973 and 79:135, 1973). Clustered cases occurred in April and May of 1972. The seven cases that can be placed exactly in time occurred since 1969. It seems reasonable to ask if the clustering in the Spring of 1972 can reasonably be ascribed to chance. The time during which the seven cases occurred can be divided into equal 3-month periods and the data analyzed by the Poisson distribution.P(x) is the probability of x occurrences in a single time block;... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOEL SPALTER, M.D.Affiliations: Infectious Disease Service Department of Medicine Morrisania Hospital Bronx, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1973Volume 79, Issue 6Page: 911-912KeywordsMeningitis ePublished: 1 December 2008 Issue Published: 1 December 1973 PDF downloadLoading ...
Neurodevelopmental outcome in babies weighing less than 2001 g at birth.
Authors: N Marlow, S W D'Souza, M L Chiswick
Journal: BMJ (1987)

From 1976 to 1980, 1034 infants with birth weights of 500-2000 g were cared for in the neonatal medical unit; 724 were discharged. Twenty (2.8%) subsequently died and 654 (90.3%) were followed up at a median age of 3 years 3 months. Fifty five (7.6%) survivors had major neurodevelopmental handicaps not attributable to congenital anomalies. Increasing prevalence of major handicap was found with decreasing birth weight and gestation. Children with birth weights of less than 1251 g had a higher incidence of all major disabilities. Handicapped children with a birth weight less than 1251 g were more likely to have blindness, deafness, multiple disabilities, and more severe cerebral palsy. There were 146 (20.2%) children with minor disabilities: neurological impairments (n = 11), borderline results on psychometric testing (n = 18), visual impairments (n = 52), hearing impairments (n = 40), and speech impairments (n = 71). Children weighing less than 1251 g at birth had a higher incidence of minor visual and hearing impairments. In 389 children the mean Griffiths quotient was 101.6 (SD 17.2) (range 50-147), and 158 children had a mean Wechsler preschool and primary intelligence quotient of 101.8 (13.2) (range 56-127): these quotients did not vary with birth weight or gestation but did vary with socioeconomic group, schooling, and family structure. During the study period an improving prognosis in terms of both survival and handicap was observed in children weighing less than 1251 g at birth.
Draconian sentence imposed on Vietnamese doctor
Authors: H. Hillman
Journal: BMJ (1992)

of proteins.Assays for total protein show poor performance in quality assurance schemes because of the diversity of methods and standards.2At all levels of protein excretion caused by glomerular disorders albumin is the main contributor.Albu- min is a discrete protein, and specific methods for measuring it are now widely available.Shihabi et al suggested that both urine total protein and albumin should be routinely esti- mated.3In our experience, in a laboratory that receives more than 2500 requests for measurement of urine protein each year, there is a linear relation between urine total protein and albumin concen- trations (r=0 924; p<0001).We consider that urine albumin concentration should replace total protein concentration for the assessment of glome- rular proteinuria.
IMMUNOLOGICAL DISTINCTIONS OF TWO STRAINS OF THE MOUSE TYPHOID GROUP ISOLATED DURING TWO SPONTANEOUS OUTBREAKS AMONG THE SAME STOCK
Authors: Harold L. Amoss, Peter P. Haselbauer
Journal: The Journal of Experimental Medicine (1922)

Two strains of the paratyphoid B-enteritidis group causing separate epidemics of mouse typhoid among 2,500 to 4,000 cancer breeding mice are found to be antigenically different. Mouse Typhoid I, isolated from the first outbreak, is related but not identical with two strains of enteritidis, while Mouse Typhoid II is related to but not identical with the human paratyphoid B strains. In a separate paper in this series, Webster has identified Mouse Typhoid II strain with Bacillus pestis caviæ Smith and has suggested its close relation to the Bacillus aertrycke (mutton) group of Schütze.
Danckwerts Award and R.M.B.F
Authors: F. Juler
Journal: BMJ (1952)

favourable position of Great Britain in this respect.In the light of that experience the remarks of Sir Max Page (November 29, p. 1203) are difficult to follow.Is it not a -fact that if we are to complete our own rehabilitation services, and to counteract the present serious trend towards protracted convalescence after illness or accident, we need more rather than less physical medicine specialists, and of the character so well described in Dr.
CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells
Authors: Aurelie Thedrez, Claudia de Lalla, Sophie Allain, Luca Zaccagnino, Stephane Sidobre, Claudio Garavaglia, Giovanna Borsellino, Paolo Dellabona, Marc Bonneville, Emmanuel Scotet, Giulia Casorati
Journal: Blood (2007)
Delayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis
Authors: Theodore E. Warkentin, John G. Kelton
Journal: Annals of Internal Medicine (2001)

Background: Heparin-induced thrombocytopenia is a prothrombotic drug reaction caused by platelet-activating antibodies that recognize complexes of platelet factor 4 and heparin. Objective: To describe a syndrome termed delayed-onset heparin-induced thrombocytopenia, in which thrombocytopenia and thrombotic events begin 5 or more days after withdrawal of heparin. Design: Case series. Setting: Secondary and tertiary care hospitals. Patients: 12 patients who presented with serologically confirmed, delayed-onset heparin-induced thrombocytopenia, including 6 outpatients presenting after hospital discharge. Measurements: The platelet serotonin-release assay was used to measure IgG-induced heparin-dependent and heparin-independent platelet activation; an enzyme immunoassay that detects IgG against platelet factor 4–heparin complexes was also used. Results: Patients with delayed-onset heparin-induced thrombocytopenia presented with thrombocytopenia and associated thrombosis a mean of 9.2 days (range, 5 to 19 days) after stopping heparin therapy. Nine patients received additional heparin, with further decrease in platelet counts. Compared with controls, patients with delayed-onset heparin-induced thrombocytopenia had higher titers of IgG antibodies to platelet factor 4–heparin and greater IgG-induced heparin-dependent and heparin-independent platelet activation. Conclusions: Delayed-onset heparin-induced thrombocytopenia should be suspected when patients present with thrombocytopenia and thrombosis up to 3 weeks after exposure to heparin. This syndrome could be caused by high titers of platelet-activating IgG induced by heparin.
Interaction of primate alveolar macrophages and Legionella pneumophila.
Authors: R F Jacobs, R M Locksley, C B Wilson, J E Haas, S J Klebanoff
Journal: Journal of Clinical Investigation (1984)

We studied the interaction between Legionella pneumophila, which is principally a pulmonary pathogen, with primate alveolar macrophages (AM), which are the primary pulmonary cellular defense mechanism. For these studies we used L. pneumophila, type I, which were grown in albumin-yeast extract broth, were greater than 80% viable, and were comparable in virulence for guinea pigs to organisms from guinea pig spleen homogenates. For comparison, avirulent agar-passed L. pneumophila, type I, and a strain of Escherichia coli were also used. In the absence of detectable antibody, AM phagocytosed similar numbers of virulent and avirulent Legionella and killed the majority of ingested Legionella in 15-30 min, as determined by two different assays. The virulent and avirulent Legionella appeared to be equally susceptible to the cidal systems of the AM and both were killed more readily than were E. coli under both assay conditions. Phagocytosis of Legionella by AM was associated with a localized respiratory burst, as indicated by nitroblue tetrazolium reduction around ingested organisms. Killing of AM-associated Legionella was inhibited by the hydroxyl radical (OH.) scavenger mannitol (but not by an equiosmolar concentration of sodium sulfate), and by a combination of superoxide dismutase and catalase (but not by either enzyme alone). These findings suggest a contribution by OH., one generated by the metal-catalyzed interaction of superoxide and hydrogen peroxide (Haber-Weiss reaction) in the anti-Legionella activity of AM. The virulent Legionella that survived intracellularly increased in number from 4 X 10(4) at 1 h to 6 X 10(6) at 96 h after infection. In contrast, avirulent Legionella replicated more slowly, increasing in number from 4 X 10(4) to 1 X 10(5) over the same period. Replication of virulent Legionella destroyed the AM monolayers by 120 h, whereas monolayers containing avirulent organisms remained intact. Thus, virulence of Legionella appears not to correlate with its ability to survive early killing by AM, but rather with the ability of the small fraction of surviving organisms to replicate within these cells.
Reduced Muscle Redox Capacity after Endurance Training in Patients with Chronic Obstructive Pulmonary Disease
Authors: ROBERTO A. RABINOVICH, ESTHER ARDITE, THIERRY TROOSTERS, NEUS CARBÓ, JULI ALONSO, JOSÉ MANUEL GONZALEZ DE SUSO, JORDI VILARÓ, JOAN ALBERT BARBERÀ, MAITE FIGUERAS POLO, JOSEP M. ARGILÉS, JOSÉ C. FERNANDEZ-CHECA, JOSEP ROCA
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

The present study was undertaken to test whether endurance training in patients with COPD, along with enhancement of muscle bioenergetics, decreases muscle redox capacity as a result of recurrent episodes of cell hypoxia induced by high intensity exercise sessions. Seventeen patients with COPD (FEV1, 38 ± 4% pred; PaO2 , 69 ± 2.7 mm Hg; PaCO2 ,42 ± 1.7 mm Hg) and five age-matched control subjects (C) were studied pretraining and post-training. Reduced (GSH) and oxidized (GSSG) glutathione, lipid peroxidation, and gamma-glutamyl cysteine synthase heavy subunit chain mRNA expression ( γ GCS-HS mRNA) were measured in the vastus lateralis. Pretraining redox status at rest and after moderate (40% Wpeak) constant-work rate exercise were similar between groups. After training ( Δ Wpeak, 27 ± 7% and 37 ± 18%, COPD and C, respectively) (p < 0.05 each), GSSG levels increased only in patients with COPD (from 0.7 ± 0.08 to 1.0 ± 0.15 nmol/ mg protein, p < 0.05) with maintenance of GSH levels, whereas GSH markedly increased in C (from 4.6 ± 1.03 to 8.7 ± 0.41 nmol/ mg protein, p < 0.01). Post-training γ GCS-HS mRNA levels increased after submaximal exercise in patients with COPD. No evidence of lipid peroxidation was observed. We conclude that although endurance training increased muscle redox potential in healthy subjects, patients with COPD showed a reduced ability to adapt to endurance training reflected in lower capacity to synthesize GSH.
An Evaluation of Replacement Fluids in Laboratory Animals following Control Hemorrhage
Authors: A. ERVINE MORRISON, JOHN S. LUNDY, HIRAM E. ESSEX
Journal: Circulation (1952)

Solutions of Dextran Ph, Plasmoid, Periston and isotonic saline were compared with serum albumin and whole blood to determine the efficacy of the former as blood substitutes. Rats, guinea pigs and dogs were used as experimental animals. Dextran Ph, Plasmoid and Periston were found to be less satisfactory than whole blood, since 50 to 80 per cent of the rats and guinea pigs survived following their use compared with 100 per cent survival when whole blood was given. There was, however, 100 per cent mortality of the animals when a blood substitute was not given.
Human Infection with<i>Ehrlichia canis</i>, a Leukocytic Rickettsia
Authors: Koichi Maeda, Norman Markowitz, Robert C. Hawley, Miodrag Ristic, Donald Cox, Joseph E. McDade
Journal: New England Journal of Medicine (1987)

RICKETTSIA that are pathogenic for humans include five main antigenic groups that cause, respectively, typhus, spotted fever, scrub typhus, Q fever, and trench fever.1 There is also a group of intraleukocytic parasites that infect humans and a variety of wild and domestic animals. These organisms constitute the genus ehrlichia of the family Rickettsiaceae.2 The human pathogen in this genus, E. sennetsu, was isolated in Japan in 1954 from a patient with an infectious mononucleosis–like syndrome.3 Sennetsu rickettsiosis was subsequently described in Japan and Malaysia.4 We now report a human infection caused by E. canis. The clinical symptoms of . . .
Specific inhibition of P-selectin–mediated cell adhesion by phage display–derived peptide antagonists
Authors: Tom J. M. Molenaar, Chantal C. M. Appeldoorn, Sonja A. M. de Haas, Ingrid N. Michon, Arnaud Bonnefoy, Marc F. Hoylaerts, Hans Pannekoek, Theo J. C. van Berkel, Johan Kuiper, Erik A. L. Biessen
Journal: Blood (2002)
Oral etoposide in the treatment of cutaneous large-cell lymphomas. A preliminary report of four cases
Authors: J.U. RIJLAARSDAM, P.C. HUIJGENS, R.C. BELJAARDS, V. BAKELS, R. WILLEMZE
Journal: British Journal of Dermatology (1992)

Journal Article Oral etoposide in the treatment of cutaneous large‐cell lymphomas. A preliminary report of four cases Get access J.U. RIJLAARSDAM, J.U. RIJLAARSDAM Department of Dermatology, Free University Hospital, The Netherlands Dr J.U. Rijlaarsdam, Department of Dermatology, Free University Hospital, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. Search for other works by this author on: Oxford Academic Google Scholar P.C. HUIJGENS, P.C. HUIJGENS Department of Dermatology, Free University Hospital, The NetherlandsDepartment of Haematology, Free University Hospital, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar R.C. BELJAARDS, R.C. BELJAARDS Department of Dermatology, Free University Hospital, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar V. BAKELS, V. BAKELS Department of Dermatology, Free University Hospital, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar R. WILLEMZE R. WILLEMZE Department of Dermatology, Free University Hospital, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 5, 1 November 1992, Pages 524–528, https://doi.org/10.1111/j.1365-2133.1992.tb14853.x Published: 01 November 1992
Abstract LB-285: Pharmacogenomic study to improve sorafenib response in hepatocellular carcinoma
Authors: Michelle Kassner, Jeff Kiefer, Nanyun Tang, Michael Barrett, Haiyong Han, Daniel Von Hoff, Mitesh Borad, Holly Yin
Journal: Cancer Research (2010)

Abstract Hepatocellular carcinoma (HCC), the primary malignancy of the liver, is the fourth leading cause of cancer deaths worldwide, with a 5-year survival rate of∼10%. Recently, a new multikinase inhibitor, sorafenib (Nexavar®), which mainly targets the VEGFR and the Raf/Mek/Erk pathways, has shown limited response rate and modest survival benefits in patients with advanced stage HCC. We hypothesize that there exist genetic alterations or contexts of vulnerability (COV) in cancer cells that dictate sensitivity to sorafenib. In order to identify specific COVs and obtain an increased understanding of drug's mechanism of action, we performed a custom chemosensitization high-throughput siRNA screen. We developed and optimized a sorafenib chemosensitization assay in 3 HCC cell lines, one of which, Hep3B, a AFP and HBsAg positive cell line, was selected for primary RNAi screening with a kinase siRNA library, which covers 700 genes (4 siRNA sequences per gene). Primary screen data was rigorously evaluated for multiple quality control metrics (transfection efficiency, CV values, accessing plate-to-plate and set-to-set variation) and found to exceed all expected performance parameters. The top sorefenib sensitizing hits were identified and supplemented with additional genes selected based on related biological concepts. This sensitization effect of the genes was further tested and compared in two additional HCC cell lines (HepG2 and PLC). Additionally, based on the sensitizer list from the RNAi screening, 11 chemical compounds were tested for synergistic combination with sorafenib. Notable synergism with sorafenib was observed in the combination with erlotinib or doxorubicin. More strikingly, we also observed synergy between sorafenib and multiple MEK inhibitors as well as gemcitabine in the selected HCC cell lines. Our data suggest that MEK inhibitors might improve the efficacy of sorafenib in HCC treatment in the clinic. Further mechanistic studies are being conducted for this particular combination. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-285.
Endoscopic retrograde cholangiopancreaticography prior to explorative laparotomy avoids unnecessary surgery in patients suspected for biliary atresia
Authors: Claus Petersen, Peter N. Meier, Andrea Schneider, Carmen Turowski, Eva D. Pfister, Michael P. Manns, Benno M. Ure, Jochen Wedemeyer
Journal: Journal of Hepatology (2009)
Patient-Controlled Sedation with Propofol and Alfentanil During Colonoscopy: A Pilot Study
Authors: C. Roseveare, C. Seavell, P. Patel, J. Criswell, H. Shepherd
Journal: Endoscopy (1998)

Background and Study Aims: Patient controlled sedation (PCS) is becoming increasingly popular in day-case surgery and has the potential for use during endoscopy. We aimed to examine its safety and acceptability during colonoscopy in a pilot study using alfentanil and propofol and assess its influence on the patient's recovery time.
P02.05 * CLINICAL STUDY PHASE II WITH DENDRITIC CELL VACCINATION AND TUMOUR LYSATE AS ADD-ON THERAPY IN HIGH GRADE GLIOMA
Authors: G. Stragliotto, S. Holm, L. Adamson, G. Giraud, J. I. Henter
Journal: Neuro-Oncology (2014)

AIM: To improve treatment of high-grade glioma (HGG) with immune therapy based on vaccination with autologous dendritic cells (DC) loaded with tumour-derived lysate (DCm-HGG-L). BACKGROUND: Immune therapy of CNS tumours is an emerging modality that potentially can enhance the current multimodal treatment approaches being used. This autologous vaccine is both tumour-specific and well tolerated, given intradermally, a technique which has been developed by van Gool et al in Leuven, Belgium. METHODS: Adult patients underwent leukaferesis after radical surgery. The DC were extracted by CD14+ enrichement with the CliniMacs platform. Blood samples for immunologic stimulation analysis (CD4, CD8) were collected prior to therapy and before each intradermal vaccination. RESULTS: Since December 2009, DCm-HGG-L has been produced at the Karolinska University Hospital for HGG patients, according to a GMP protocol required by the Medical Product Agency. Twelve patients have been treated, 6 with de novo glioblastoma, 4 with recurrent high grade glioma, one with recurrent PNET, and one with recurrent rhabdoid tumor. Age 2 and 20-50 yr, KPS 70-100. All underwent radical surgery followed by radiochemotherapy. Median PFS < 6 mo (3-18 m) for 6 patients. OS: 2 patients with recurrent tumor died between 3-6 months after treatment, three other are alive without recurrence at 1 year. The child has been treated for < 6 mo. De novo GBM OS is > 2 yrs. The CD4 and CD8 blasts increased and remained at high level after the 3 rd vaccine. CONCLUSION: The immunological therapy for High Grade Glioma is safe. Further evaluation is under way to implement this strategy, especially in the adult population.
Suppression of actopaxin impairs hepatocellular carcinoma metastasis through modulation of cell migration and invasion
Authors: Lui Ng, Ronnie Tung-Ping Poon, Simon Yau, Ariel Chow, Colin Lam, Hung-Sing Li, Thomas Chung-Cheung Yau, Wai-Lun Law, Roberta Pang
Journal: Hepatology (2013)

Early reports suggested that actopaxin, a member of the focal adhesion proteins, regulates cell migration. Here we investigated whether actopaxin is involved in hepatocellular carcinoma (HCC) progression and metastasis. We examined actopaxin expression in human HCC samples using immunohistochemistry and western blotting. The functional and molecular effect of actopaxin was studied in vitro by overexpression in a nonmetastatic HCC cell line, as well as repression in a metastatic cell line. The in vivo effect of actopaxin repression was studied in nonobese diabetic and severe combined immunodeficient mice. We found that actopaxin was frequently overexpressed in human HCC patients and its overexpression positively correlated with tumor size, stage, and metastasis. Actopaxin expression also correlated with the metastatic potential of HCC cell lines. Actopaxin overexpression induced the invasion and migration ability of nonmetastatic HCC cells, whereas down-regulation of actopaxin reverted the invasive phenotypes and metastatic potential of metastatic HCC cells through regulating the protein expression of certain focal adhesion proteins including ILK, PINCH, paxillin, and cdc42, as well as regulating the epithelial-mesenchymal transition pathway. Furthermore, there was a close association between actopaxin and CD29. HCC cells with stronger CD29 expression showed a higher actopaxin level, whereas actopaxin repression attenuated CD29 activity. Finally, actopaxin down-regulation enhanced the chemosensitivity of HCC cells towards oxaliplatin treatment by way of a collective result of suppression of survivin protein, β-catenin, and mammalian target of rapamycin pathways and up-regulation of p53.This study provides concrete evidence of a significant role of actopaxin in HCC progression and metastasis, by way of regulation of cell invasiveness and motility, an epithelial-mesenchymal transition process, and chemosensitivity to cytotoxic drugs.
72 MAPPING EXPRESSION QUANTITATIVE TRAITS LOCI (eQTL) FOR PNPLA3 GENE IDENTIFIES ADDITIONAL SNPS ASSOCIATED WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) INDEPENDENT OF rs738409
Authors: X. Wang, R.M. Onjiko, Q.M. Anstee, V. Ratziu, Y.-L. Liu, H.J. Cordell, R. Darlay, C.P. Day, A.K. Daly, N. Chalasani, W. Liu
Journal: Journal of Hepatology (2013)