tbuckley/cabot-search huggingface dataset:
Electrophysiological characteristics of rodent myocardium damaged by adrenaline
Authors: R. F GILMOUR, D. P ZIPES
Journal: Cardiovascular Research (1980)

Myocardial cell injury was produced in rats and guinea pigs by injecting 3.0 mg·kg−1 1-adrenaline subcutaneously. Ventricular myocardium removed from animals 24 h after the injection exhibited marked electrophysiological alterations when studied in vitro. These alterations included: (1) reduced resting membrane potential, action potential amplitude and duration, and dV/dt; (2) conduction disturbances such as delay, unidirectional block, summation and inhibition; (3) abnormal automatic activity including triggered sustained rhythmic activity and post-overdrive acceleration. Conduction disturbances were affected by stimulus intensity, duration, rate and site of pacing. Isoprenaline (10−7mol·litre−1) improved conduction. Automatic activity was modified by changes in entrance and exit block and depolarising or hyperpolarising current pulses. These data indicate that diverse abnormal electrophysiological alterations occur in myocardium damaged by adrenaline.
Blood Cultures Drawn Through Catheters-Reply
Authors: Alan Tonnesen
Journal: JAMA (1976)

In answer to Dr Handsfield's question, 15 of the 161 comparisons involved identical positive cultures from both sites.  The reason for the high rate of isolation of Staphylococcus epidermidis from catheter-drawn cultures remains an important question. As stated in the article, the significance of an isolated culture revealing this organism is unknown. Providing one is willing to withhold making any conclusion regarding Staphylococcus epidermidis , the method is valid.
Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma
Authors: Chrystal U. Louis, Barbara Savoldo, Gianpietro Dotti, Martin Pule, Eric Yvon, G. Doug Myers, Claudia Rossig, Heidi V. Russell, Oumar Diouf, Enli Liu, Hao Liu, Meng-Fen Wu, Adrian P. Gee, Zhuyong Mei, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner
Journal: Blood (2011)
Bridging the training gap in laparoscopic colorectal surgery
Authors: P. S. Kang, Y. Tabbakh
Journal: BMJ (2012)

In 2009, 53% of colorectal surgeons were performing a quarter of all colorectal procedures laparoscopically.1 2 A recent survey of colorectal surgery specialist trainees found that 85% of trainees did not feel ready to perform laparoscopic colorectal surgery at completion of specialist training (CCT).3 Therefore, despite the widespread availability of laparoscopic colorectal surgery, …
The Injuries to JFK-Reply
Authors: Marc S. Micozzi
Journal: JAMA (1992)

<h3>In Reply.</h3> —Like Dr Wilson of the Duckworth Pathology Group in Memphis, Tenn, I never had serious grounds to doubt that President Kennedy was struck from above and behind by two bullets. However, also like Wilson, I was not able to rest easy about the "single-bullet theory"—that a single bullet struck the President and subsequently caused all the injuries to Governor Connally—until my viewing of the video presentation of the Zapruder film by Johann Rush and Michael West at the American Academy of Forensic Sciences meetings in New Orleans, La, on February 19, 1992. In this film presentation it is illustrated that a first shot was fired from the rear that did not hit anyone. Governor Connally, as he later reported, heard this first shot and is seen in the film leaning backward and looking back over his shoulder to see what was wrong. Within seconds, a second shot was
Pyoderma gangrenosum and interleukin 8
Authors: M. Oka
Journal: British Journal of Dermatology (2007)

Journal Article Pyoderma gangrenosum and interleukin 8 Get access M. Oka M. Oka Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650‐0017, Japan E‐mail: oka@med.kobe‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 6, 1 December 2007, Pages 1279–1281, https://doi.org/10.1111/j.1365-2133.2007.08202.x Published: 01 December 2007
Artificial Cardiac Pacemakers
Authors: Bernard Lown, Bernard D. Kosowsky
Journal: New England Journal of Medicine (1970)

Indications for PacingThe indications for pacing will be considered under four clinical categories: Stokes-Adams syndrome; bradyarrhythmia; acute myocardial infarction; and overdrive.Stokes-Adams SyndromeThere is reason for limiting designation of this syndrome to patients with complete heart block who suffer from loss of consciousness due to bradycardia, asystole, ventricular tachycardia, ventricular fibrillation or a combination of these arrhythmias.75 It has been estimated that there are 50 new cases of complete heart block per 1,000,000 population per year.17 In approximately 2/3 of such patients syncope will develop. The heart block may be chronic or intermittent and recognized only by prolonged . . .
Quantitation of sinusoid-like vessels in hepatocellular carcinoma: Its clinical and prognostic significance.
Authors: N Tanigawa
Journal: Hepatology (1997)

Angiogenesis is crucial for tumor growth and metastasis. Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. However, the relationship between tumor vascularity and the outcome of patients with HCC has not been evaluated. To clarify whether tumor angiogenesis is related to the prognosis of patients, immunohistochemical staining, using anti-von Willebrand factor (vWF) and anti-CD34, was applied in resected specimens from 43 cases of HCC. In nonmalignant tissue, staining was confined to vessels in the portal tract and to a few periportal sinusoids with both of the endothelial markers applied. In tumor tissue, however, sinusoid-like vessels reacted intensively with anti-CD34 but not with anti-vWF. The intratumor microvessel density (MVD) highlighted by anti-CD34 was 297 +/- 88 (per 0.74 mm2), which was significantly higher than that highlighted by anti-vWF (4 +/- 7). When only the MVD highlighted by anti-CD34 was analyzed, tumor diameter larger than 2 cm, poor differentiation (Edmondson's II to IV), and portal invasion were significantly related to the subgroup with MVD > or = 290. Overall survival curves of patients with MVD < 290 were better, and these patients were more likely to remain tumor free. Cox hazards model revealed intratumor MVD and Edmondson's grade to be independent prognostic factors for the overall survival of patients. These results demonstrated for the first time that tumor angiogenesis assessed by anti-CD34 was correlated with the outcome of patients with HCC, suggesting a potential role for anti-CD34 in the diagnosis and treatment of HCC.
Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions
Authors: Yvonne Dombrowski, Mark Peric, Sarah Koglin, Claudia Kammerbauer, Christine Göß, David Anz, Maren Simanski, Regine Gläser, Jürgen Harder, Veit Hornung, Richard L. Gallo, Thomas Ruzicka, Robert Besch, Jürgen Schauber
Journal: Science Translational Medicine (2011)

In psoriasis, cytosolic DNA in keratinocytes triggers maturation of the cytokine IL-1β via the AIM2 inflammasome.
TCT-637 A Novel Bioactive and Coating-Free Stent Surface Exhibits a Reduction in Neointimal Hyperplasia by Decreasing Platelet Aggregation and Promoting Endothelialization
Authors: Lynn Bailey, Adam Groothuis, Arik Zucker, Stefano Buzzi, Armin Mäder, Algirdas Ziogas, Vincent Milleret, Martin Ehrbar, Elazer Edelman
Journal: Journal of the American College of Cardiology (2012)
Pigs and Pandemic Influenza
Authors: Tracy Hampton
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis
Authors: Shuo Yang, Bingwei Wang, Fiachra Humphries, Ruaidhri Jackson, Marc E Healy, Ronan Bergin, Gabriella Aviello, Barry Hall, Deirdre McNamara, Trevor Darby, Aoife Quinlan, Fergus Shanahan, Silvia Melgar, Padraic G Fallon, Paul N Moynagh
Journal: Nature Immunology (2013)
Cost price drugs for developing countries are found in Belgian pharmacies
Authors: O. Dyer
Journal: BMJ (2002)

The pharmaceutical industry's programme of sending HIV/AIDS drugs to Africa at preferential prices has been undermined by unscrupulous traders reimporting the cheap drugs to Europe for sale at full price, it emerged last week.

An investigation by Belgian customs authorities found that at least three million doses of GlaxoSmithKline's Combivir (zidovudine)—earmarked for sale in Africa at about £0.50 (€ 0.80; $0.78) per dose—have found their way onto European pharmacists' shelves, where they sell for about £3.80 (£6.00; $5.94) per dose. Quantities of GlaxoSmithKline's antiretroviral drugs Epivir (lamivudine) and Trizivir (abacavir) have also been illegally diverted back to Europe.

The drugs were supposed to go to HIV/AIDS …
Farnesyltransferase inhibitor tipifarnib (R115777) preferentially inhibits in vitro autonomous erythropoiesis of polycythemia vera patient cells
Authors: Jérôme Larghero, Nathalie Gervais, Bruno Cassinat, Jean-Didier Rain, Marie-Hélène Schlageter, Rose Ann Padua, Christine Chomienne, Philippe Rousselot
Journal: Blood (2005)
Let someone else sign off sick notes
Authors: Kinesh Patel
Journal: BMJ (2011)

“There’s an outbreak of diarrhoea, vomiting, and MRCP exams at the hospital,” lamented my wife, complaining about being on call without the usual complement of junior staff. “Doctor” and “sickie” aren’t two words that often appear in the same sentence but it would be naive to suggest that doctors never fake illness to avoid work. And if professionals—widely perceived to be paragons of virtue—do it, just imagine what is happening among the country at large. The unfortunate fact is that long …
The Status of Oral Surgery
Authors: Kurt H. Thoma
Journal: New England Journal of Medicine (1957)

THE dental profession acclaims oral surgery as a well established specialty of dentistry. It was under the aegis of dentistry that this specialty developed. The educational standards, the evolution of oral-surgery literature and the establishment of the American Board of Oral Surgery all matured under the auspices of the profession of dentistry. In spite of these facts, certain medical groups, perhaps because of economic conditions affecting their own fields, are eyeing with envy the grass on the other side of the fence. There are, in addition to these inroads into the specialty of oral surgery, evidences of misunderstanding arising from . . .
THE CAUSATIVE FACTOR IN THE PRODUCTION OF THE DERMATITIS OF GROUND ITCH (UNCINARIASIS).
Authors: CLAUDE A. SMITH
Journal: JAMA (1906)

In studying the inflammation produced by the larvæ of the<i>Uncinaria americana</i>in their passage through the skin, the question arose as to whether the mechanical irritation produced by the presence of the larvæ would account for the vesicular eruption and the intense swelling of the tissues. As previously reported,<sup>1</sup>it was noticed that the eruption of ground itch, while very angry looking, showed very little tenderness on pressure, but was accompanied by an excruciating itching, and the inflammation did not appear to be due to bacterial infection. After considering the eruption and the accompanying symptoms, it appeared that possibly the eruption, the swelling and the intense itching might be due to some substance secreted by the larvæ and poured out into the skin. If such a substance were excreted, might it be present in the bodies of the larvæ before they begin to make their way into the
HLA-DR typing in identical twins with insulin-dependent diabetes: difference between concordant and discordant pairs.
Authors: C Johnston, D A Pyke, A G Cudworth, E Wolf
Journal: BMJ (1983)

A total of 106 pairs of identical twins, of whom 56 were concordant and 50 discordant for insulin-dependent diabetes, were typed for HLA-DR. In both the concordant and discordant groups there was a high prevalence of the antigens DR3 and DR4, a low prevalence of DR5 and DR7, and a virtual absence of DR2. The heterozygous phenotype DR3,DR4 was more prevalent in concordant than discordant pairs. This was therefore the first demonstration of a genetic difference between concordant and discordant identical twin pairs. These findings suggest that possession of both DR3 and DR4 antigens confers a greater genetic predisposition to insulin-dependent diabetes than does the possession of either antigen alone.
Plasma contact system activation drives anaphylaxis in severe mast cell–mediated allergic reactions
Authors: Anna Sala-Cunill, Jenny Björkqvist, Riccardo Senter, Mar Guilarte, Victoria Cardona, Moises Labrador, Katrin F. Nickel, Lynn Butler, Olga Luengo, Parvin Kumar, Linda Labberton, Andy Long, Antonio Di Gennaro, Ellinor Kenne, Anne Jämsä, Thorsten Krieger, Hartmut Schlüter, Tobias Fuchs, Stefanie Flohr, Ulrich Hassiepen, Frederic Cumin, Keith McCrae, Coen Maas, Evi Stavrou, Thomas Renné
Journal: Journal of Allergy and Clinical Immunology (2014)
Exhaled Nitric Oxide Following Repeated Spirometry or Repeated Plethysmography in Healthy Individuals
Authors: AARON DEYKIN, ANTHONY F. MASSARO, ERIN COULSTON, JEFFREY M. DRAZEN, ELLIOT ISRAEL
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Subjects with asthma have higher concentrations of exhaled nitric oxide (NO) than normal individuals. It has been demonstrated that in asthmatics, repeated FVC maneuvers reduce NO. Although the cause of this phenomenon is not known, it has been hypothesized that deep breaths associated with FVC maneuvers reduce exhaled NO by affecting neural sources of NO, possibly via a mechanism related to the pathobiology of asthma. To establish whether FVC maneuvers influence NO concentrations in normal individuals, we measured exhaled NO at baseline values and after FVC maneuvers performed every 15 min for 1 h in subjects without asthma. To investigate the role of deep breaths in reducing exhaled NO, we compared these results with concentrations of exhaled NO after plethysmography. Repeated FVC maneuvers over 60 min produced a decrease in NO concentrations in mixed expired gas (F(E)NO; 24.6 +/- 5.1% decrease for F(E)NO, p < 0. 01 versus baseline). In contrast to the results after spirometry, repeated specific airway conductance (sGaw) maneuvers do not have a significant effect on F(E)NO (p = 0.16). These results, which demonstrate that in nonasthmatic subjects FVC maneuvers-but not panting maneuvers-produce a fall in NO, suggest that the mechanism responsible for the reduction in exhaled NO after FVC maneuvers is related to volume history of the lung rather than the pathobiology of asthma.
Does the variation in the socioeconomic characteristics of an area affect mortality?
Authors: Y. Ben-Shlomo, I. R White, M. Marmot
Journal: BMJ (1996)

Our research in England has shown that the more deprived an area the greater its incidence of premature mortality.1 Wilkinson has argued that in the developed world income distribution is a more important predictor of life expectancy between countries than simply mean income.2 We aimed to determine whether the risk of mortality in a geographical area was related to the degree of socioeconomic variation within that area as well as the average level of deprivation.

For each of the 8464 wards in England we obtained the Townsend deprivation index from the 1981 census1 and directly standardised all cause mortality for 1981-5. Mortality under the age of 65 was used as an indicator of premature mortality. Male and female mortality rates were averaged for each ward. Twenty four wards were …
Abstract 2181: Characterization of PHF11, a candidate tumor suppressor gene, in esophageal squamous cell carcinoma
Authors: Wai Ying Cheung, Josephine Mun Yee Ko, Zhuoyou Yu, Maria Li Lung
Journal: Cancer Research (2012)

Abstract Background and aims: Esophageal squamous cell carcinoma (ESCC) has a high incidence in China, with five-year survival rates in Hong Kong of only 10.7%. Loss of chromosome 13q regions is a frequent event in ESCC. A candidate tumor suppressor gene (TSG), PHF11, located at 13q14.2 was identified from our previous chromosome transfer study and shows 100% down-regulation in 18 cancer cell lines, including 16 ESCC cell lines, compared to expression in an immortalized normal esophageal epithelial cell line. This study aims to investigate the functional role of PHF11 in ESCC and to investigate the possible role of PHF11 in transcriptional regulation or histone modification as the proteins in the plant homeodomain finger (PHF) protein family are reported to contribute to the two implicated functions. Methods: Real-time PCR was carried out to validate the expression of PHF11 in tumor tissues of ESCC patients compared to their respective normal counterparts. The two isoforms of PHF11, PHF11a and PHF11b, were cloned into expression vectors and transfected into ESCC cell lines, KYSE150 and KYSE180, respectively. Clones expressing PHF11 were established for colony formation assay and MTT assay. To identify the subcellular localization of PHF11, subcellular fractionation was performed using immortalized normal esophageal epithelial cell lines followed by SDS-PAGE and Western blotting. Results: Real-time PCR verified that 42% of the 41 patient samples showed at least 2-fold down-regulation in PHF11 expression. The colony formation assay showed that the two isoforms of PHF11, PHF11a and PHF11b, have the ability to suppress cell growth using two ESCC cell lines, KYSE150 and KYSE180. The MTT assay also showed that both isoforms of PHF11 have the ability to suppress cell proliferation. Our data showed that PHF11 is localized in the nucleus of the immortalized normal esophageal epithelial cell lines. Conclusions: It was observed that almost half of the patient samples screened showed a significant down-regulation of PHF11, suggesting its possible role as a candidate TSG. Suppression of colony growth and cell proliferation in the PHF11 expressing clones indicate that the protein may suppress tumorigenicity of ESCC cells. The nuclear localization of PHF11 observed in the immortalized normal esophageal epithelial cell line is consistent with a possible role in transcriptional regulation or histone modification, though further studies are required to further investigate this. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2181. doi:1538-7445.AM2012-2181
Highlights of the 1989 EDUCATION ISSUE
Authors: Anne E. Crowley
Journal: JAMA (1989)

Eighty-nine years ago, JAMA first published an EDUCATION ISSUE to call attention to the need for improvement in medical education in the United States. In the past few years, the medical education community has been concerned about the outcome (or product) of US medical education.  The editorial by Dr Martini argues for outcome evaluation measures as an important step in assessing the educational  Medical School Enrollment  The number of applicants to US schools accredited by the Liaison Committee on Medical Education (LCME) for the 1988-1989 academic year decreased by 1402 individuals. Of the 26721 applicants, 17108 students were accepted by at least one school for enrollment in the fall of 1988. The number of medical students enrolled in the first year equaled 16781. The percentage of A students entering has decreased and the average Medical College Admission Test score of entering students is down. Two other characteristics of the entering
How Our Current Medical Care System Fails People With Diabetes
Authors: Mayer B. Davidson
Journal: Diabetes Care (2009)

Many randomized controlled intervention trials have demonstrated that lowering glycemia (1,2), LDL cholesterol (3), and blood pressure (4) will markedly benefit the complications from diabetes. Based on these data, the American Diabetes Association has recommended the following targets for glycemic, lipid, and blood pressure outcome measures, A1C <7.0%, LDL cholesterol <100 mg/dl, and blood pressure <130/80 mmHg, respectively (5).

Most diabetic patients do not meet these recommended goals. Approximately half of the National Health and Nutrition Examination Survey cohort met the glycemic goal (6). In other larger reported populations, 21–43% of patients had A1C levels >9.5%, only 22–46% of diabetic patients met the LDL cholesterol goal, and 29–33% met the blood pressure goal (7). Far fewer, 2–10%, met the combined American Diabetes Association goals for glycemia, lipids, and blood pressure (7).

Many approaches have been tried to improve diabetes care but, with one exception, have been mostly ineffective. These include simply reminding patients about appointments; providing laboratory information on the patient to the physician, even when specific treatment recommendations for the individual patient were included; case management when the case manager could not make independent treatment decisions; education of physicians; and multifaceted quality improvement interventions in the practice setting (7).

The small amount of time a physician has to spend with a patient is an important limiting factor. This was amply illustrated in a study (8) in which eight process measures agreed upon by the physician group and whether the patient was due to receive them were displayed on the physicians’ computer screens at the time of the patient visit. The measures due were performed or ordered only one-third of the time. Physicians pinpointed lack of time and other problems that needed attention as primary obstacles to carrying out the agreed-upon recommendations.

The one approach …
Do drugs change the course of rheumatoid arthritis?
Authors: V Wright, R Amos
Journal: BMJ (1980)

problem of supply.Possibly the development centres that have contributed so much will try to meet demands through- out Britain, or the matter may be handed over to industry.As is so frequently the case with new technological developments in the Health Service, no single organisation has clear responsibility for initiating and seeing through the creation of a seat-support for the disabled.A team approach may be the counsel of perfection, but who is to assemble and lead the team ?These difficulties recognised, there is little doubt that the development engineering skills are available to provide adequate seating for the disabled.Whether use is made of these skills will doubtless depend on the determination of clinicians and the allocation ofall-too-scarce resources.
THE PROGNOSIS IN WAR NEPHRITIS: AN ANALYSIS OF 171 CASES
Authors: R. G. Abercromble
Journal: BMJ (1918)

PROGNOSIS IN' WAR NEPHIRITIS.[MAY 49 IKS- An interesting feature and one very difficult to explain is that tlle worm which was removed in 1911, that is, witlhin two years of the first possibility of infection, was 60 mm. in lenth, whilst this one, removed seven years