tbuckley/cabot-search huggingface dataset:
Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells
Authors: Kakali Sarkar, Sergio Rey, Xianjie Zhang, Raul Sebastian, Guy P. Marti, Karen Fox-Talbot, Amanda V. Cardona, Junkai Du, Yee Sun Tan, Lixin Liu, Frank Lay, Frank J. Gonzalez, John W. Harmon, Gregg L. Semenza
Journal: Cardiovascular Research (2011)

Hypoxia-inducible factor 1 (HIF-1) is a heterodimer composed of HIF-1α and HIF-1β subunits. HIF-1 is known to promote tissue vascularization by activating the transcription of genes encoding angiogenic factors, which bind to receptors on endothelial cells (ECs) and bone marrow-derived angiogenic cells (BMDACs). In this study, we analysed whether HIF-1 activity in the responding ECs and BMDACs is also required for cutaneous vascularization during burn wound healing.We generated mice with floxed alleles at the Hif1a or Arnt locus encoding HIF-1α and HIF-1β, respectively. Expression of Cre recombinase was driven by the Tie2 gene promoter, which is expressed in ECs and bone marrow cells. Tie2Cre(+) and Tie2Cre(-) mice were subjected to burn wounds of reproducible diameter and depth. Deficiency of HIF-1α or HIF-1β in Tie2-lineage cells resulted in delayed wound closure, reduced vascularization, decreased cutaneous blood flow, impaired BMDAC mobilization, and decreased BMDAC homing to burn wounds.HIF-1 activity in Tie2-lineage cells is required for the mobilization and homing of BMDACs to cutaneous burn wounds and for the vascularization of burn wound tissue.
Effects of Propranolol and Isosorbide Dinitrate on Exercise Performance and Adrenergic Activity in Patients with Angina Pectoris
Authors: DENNIS J. BATTOCK, HECTOR ALVAREZ, CHARLES A. CHIDSEY
Journal: Circulation (1969)

Twelve patients with angina pectoris were evaluated in a single blind crossover study with respect to objective changes in exercise performance on the treadmill and subjective, clinical improvement on oral administration of propranolol, isosorbide dinitrate (ISD), and a combination of propranolol and ISD. Combined objective and subjective evaluations showed that nine of 12 patients improved on propranolol, seven of 10 on ISD, and all 10 on the combination of drugs. The differences in objective improvement between the various drug regimens were not significant. However, subjectively all patients on the combination of drugs improved markedly. The patients on propranolol or the combination had a decrease in pressure-rate index of about 30% both at rest and during exercise, while these values did not change on ISD. A significant reduction in exercise-induced S-T depression was observed with propranolol alone and in combination with ISD at grade 3+ pain. Adrenergic activity, estimated from plasma and urinary catecholamines, appeared to be increased in these patients before drug treatment and was not altered during treatment. It is concluded that propranolol, ISD, and the combination of these drugs all improve exercise performance in patients with angina. Although the combination of drugs could not be shown to produce a greater increase in exercise performance than either drug alone, the combination effected a greater overall clinical improvement.
A CATENOID CONFIGURATION IS ASSOCIATED STRONGLY WITH REGIONAL STRAIN PROPERTIES IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
Authors: kazuhisa nishimura, Hideki Okayama, Katsuji Inoue, Makoto Saito, Toyofumi Yoshii, Go Hiasa, Takumi Sumimoto, Takayuki Nagai, Jun Suzuki, Akiyoshi Ogimoto, Tomoaki Ohtsuka, Junichi Funada, Jitsuo Higaki
Journal: Journal of the American College of Cardiology (2010)
Electrophysiologic Observations Concerning the Genesis of Ventricular Fibrillation.
Authors: L. S. Dreifus
Journal: Annals of Internal Medicine (1963)

s1 April 1963Electrophysiologic Observations Concerning the Genesis of Ventricular Fibrillation.L. S. Dreifus, M.D., F.A.C.P., Y. Watanabe, M.D., V. Satinsky, M.D., W. Likoff, M.D., F.A.C.P.L. S. Dreifus, M.D., F.A.C.P.Search for more papers by this author, Y. Watanabe, M.D.Search for more papers by this author, V. Satinsky, M.D.Search for more papers by this author, W. Likoff, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-712_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA satisfactory theory of ventricular fibrillation must explain; (1) initiation of a premature systole and a series of re-entrant waves, and (2) the factors engendering their transformation into fibrillation.Ten dogs were placed under hypothermia with the aid of cardiopulmonary bypass. Transmembrane potentials, utilizing 2 microelectrodes, and a surface electrogram were recorded simultaneously. Ventricular fibrillation was produced spontaneously by focal heating. Continuous recordings during the transition from a normal action potential to fibrillation potentials showed the following sequence of events: 1. Fibrillation is preceded by one or more ventricular premature systoles with a slow rate of depolarization and incomplete propagation.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 712-712KeywordsAction potentialsAtrial fibrillationCardiopulmonary bypassDepolarizationElectrode recordingElectrophysiological techniquesHypothermiaMembrane potentialSystoleVentricular fibrillation ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
Universal Coverage One Head at a Time — The Risks and Benefits of Individual Health Insurance Mandates
Authors: Sherry A Glied
Journal: New England Journal of Medicine (2008)

Interview with Sherry Glied on the risks and benefits of individual health insurance mandates. (08:23)Download The health insurance reform enacted in Massachusetts in 2006 and the proposals of the leading Democratic presidential candidates seek to achieve universal health insurance coverage while relying primarily on private insurance. Achieving universality is a challenge in any system that assigns insurance coverage, whether private or public, to identifiable individuals. The difficulties of finding, enrolling, and accounting for all eligible participants escalate when most of the financing for coverage is expected to come from premiums paid directly to multiple insurers rather than from funds collected centrally by the government through taxation. To address this problem, some reform models incorporate an . . .
Has RoboCop Got Diabetes?
Authors: Barry H. Ginsberg, Kenneth Strauss
Journal: Diabetes Care (2004)

We thank Berger et al. (1) for raising questions about the serious issue of reusing insulin syringes and pen needles. The source of the photographs used by Becton Dickinson is an independent study conducted in 1997 by Dr. Jacques Garden, Chairman of the Department of Metallurgy at the University of Grenoble, France (unpublished observation).

In Garden’s study, 80 diabetic patients from the Diabetes Service of Dr. Dieter Look returned their used pen needles and indicated the number of times each specific needle had been used. All needles were used in a customary fashion and spanned the range of manufacturer types, …
Gallstone Simulating Renal Lesion on Skeletal Scintigraphy
Authors: A MILCARE GENTILI, STEFAN D. MIRON, ERROL M. BELLON
Journal: Clinical Nuclear Medicine (1992)

The kidneys are the primary route by which Tc-99m MDP is excreted, and they normally are well visualized on skeletal scintigraphy. On the anterior view of a skeletal scintigram, large calcified gallstones may attenuate gamma rays emitted by the kidneys, simulating a space-occupying lesion, but the renal appearance remains normal on the posterior view. It is important that attenuation by gallstones not be mistaken for renal pathology. A case is presented in which attenuation from a large gallstone mimics a focal area of decreased uptake in the upper pole of the right kidney.
Regulatory Mechanisms Controlling the Intestinal Absorption of Iron: Absorption of Cobalt in Patients with Normal Iron Repletion, Iron Deficiency, and Iron Overload.
Authors: L. S. Valberg
Journal: Annals of Internal Medicine (1968)

s1 May 1968Regulatory Mechanisms Controlling the Intestinal Absorption of Iron: Absorption of Cobalt in Patients with Normal Iron Repletion, Iron Deficiency, and Iron Overload.L. S. Valberg, M.D., D. Olatunbosun, M.D.L. S. Valberg, M.D.Search for more papers by this author, D. Olatunbosun, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1172_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo investigate the poorly understood intracellular mechanisms involved in intestinal iron transport a study was made of the absorption of cobalt, which has a closely related electron structure. Absorption was measured by a fecal excretion technique using59Fe and57Co tracers. In 12 subjects in a state of normal iron repletion the average absorption of 20 µmoles of iron and cobalt administered with 200 µmoles of ascorbic acid was similar, 44 and 49%, respectively. The addition of 80 µmoles of carrier iron to the test dose produced a significant reduction in cobalt absorption, and carrier cobalt had a similar effect... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. S. Valberg, M.D.; D. Olatunbosun, M.D.Affiliations: Kingston, Ontario, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1172-1173KeywordsExcretionIron deficiency ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Priorities for health and social services
Authors: A D Forrest
Journal: BMJ (1976)

large series can show whether the incidence of handicap is reduced.The second is that there is some hope that if more resources for the handicapped are used effectively the long-term consequence may be a reduction in the pressure for hospital places.If the handicapped and their families can be given the help that is needed to avoid institutional care in childhood the extent of dependency among the adult handicapped may well be reduced.This too is prevention.The dichotomy that you suggest between spending on obstetric services or on services for the handicapped is a peculiarly unfortunate one.The acute services on which spending might be more reasonably limited are those devoted to the avoidable diseases that you instance.Perhaps the sustained campaign of health education that you suggest could be funded by diverting resources devoted to these conditions.At least it would seem reason- able to make any further spending on these acute services conditional on such a campaign.
Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia
Authors: Richard R. Furman, Jeff P. Sharman, Steven E. Coutre, Bruce D. Cheson, John M. Pagel, Peter Hillmen, Jacqueline C. Barrientos, Andrew D. Zelenetz, Thomas J. Kipps, Ian Flinn, Paolo Ghia, Herbert Eradat, Thomas Ervin, Nicole Lamanna, Bertrand Coiffier, Andrew R. Pettitt, Shuo Ma, Stephan Stilgenbauer, Paula Cramer, Maria Aiello, Dave M. Johnson, Langdon L. Miller, Daniel Li, Thomas M. Jahn, Roger D. Dansey, Michael Hallek, Susan M. O'Brien
Journal: New England Journal of Medicine (2014)

Patients with relapsed chronic lymphocytic leukemia (CLL) who have clinically significant coexisting medical conditions are less able to undergo standard chemotherapy. Effective therapies with acceptable side-effect profiles are needed for this patient population. In this multicenter, randomized, double-blind, placebo-controlled, phase 3 study, we assessed the efficacy and safety of idelalisib, an oral inhibitor of the delta isoform of phosphatidylinositol 3-kinase, in combination with rituximab versus rituximab plus placebo. We randomly assigned 220 patients with decreased renal function, previous therapy-induced myelosuppression, or major coexisting illnesses to receive rituximab and either idelalisib (at a dose of 150 mg) or placebo twice daily. The primary end point was progression-free survival. At the first prespecified interim analysis, the study was stopped early on the recommendation of the data and safety monitoring board owing to overwhelming efficacy. The median progression-free survival was 5.5 months in the placebo group and was not reached in the idelalisib group (hazard ratio for progression or death in the idelalisib group, 0.15; P<0.001). Patients receiving idelalisib versus those receiving placebo had improved rates of overall response (81% vs. 13%; odds ratio, 29.92; P<0.001) and overall survival at 12 months (92% vs. 80%; hazard ratio for death, 0.28; P=0.02). Serious adverse events occurred in 40% of the patients receiving idelalisib and rituximab and in 35% of those receiving placebo and rituximab. The combination of idelalisib and rituximab, as compared with placebo and rituximab, significantly improved progression-free survival, response rate, and overall survival among patients with relapsed CLL who were less able to undergo chemotherapy. (Funded by Gilead; ClinicalTrials.gov number, NCT01539512.).
Clinical Importance of the Interaction of Diazepam and Cimetidine
Authors: David J. Greenblatt, Darrell R. Abernethy, Diane S. Morse, Jerold S. Harmatz, Richard I. Shader
Journal: New England Journal of Medicine (1984)

Cimetidine is known to impair the hepatic microsomal oxidation of diazepam, reducing its clearance and prolonging its half-life. We studied the clinical importance of this effect in 10 patients, who were receiving long-term treatment with diazepam for anxiety, tension, or difficulty in sleeping, in an eight-week double-blind controlled study during which the diazepam dosage remained constant. The study was in four two-week phases: base-line or adaptation, coadministration of cimetidine (300 mg) or matching placebo four times daily, crossover to the opposite treatment (placebo or cimetidine), and recovery treatment with diazepam alone. During the cimetidine phase, plasma concentrations of diazepam plus desmethyldiazepam rose an average of 57 per cent (P<0.005), then fell when cimetidine was withdrawn. However, there were no significant changes in scores on the digit-symbol-substitution test, a tracking task, or a reaction-time test. Clinical self-ratings indicated no increases in sedation, fatigue, or drowsiness. Patients experienced shortening of sleep latency (P<0.05) and an increase in self-rated depth or soundness of sleep (P<0.001) during the cimetidine period, but there were no changes in sleep duration or in the number of nocturnal awakenings. Although coadministration of cimetidine to diazepam-treated patients causes a large increase in plasma diazepam and desmethyldiazepam concentrations, the increase is of minimal clinical importance. (N Engl J Med 1984; 310:1639–43.)
Monitoring excess mortality in Europe
Authors: M. R. Laurent
Journal: BMJ (2013)

The Belgian Scientific Institute for Public Health reported 10% excess mortality in June 2013 (700 additional deaths a month) in those aged 65 and older.1 No likely cause was identified because climatic circumstances, air pollution levels, and physician visits for influenza-like illnesses were unremarkable. However, it is expected that July’s heat wave …
MYCETOMA AND TRICHOPHYTON RUBRUM
Authors: George Thorne
Journal: British Journal of Dermatology (1975)

Journal Article MYCETOMA AND TRICHOPHYTON RUBRUM Get access George Thorne George Thorne Veterans Administration Hospital, Denver, Colorado 80220, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 2, 1 February 1975, Page 231, https://doi.org/10.1111/j.1365-2133.1975.tb03067.x Published: 01 February 1975
Predicting child abuse: signs of bonding failure in the maternity hospital.
Authors: M A Lynch, J Roberts
Journal: BMJ (1977)

Fifty children referred to the Park Hospital because of actual or threatened abuse were compared with 50 controls born at the same maternity hospital. Five factors were significantly more common in the abused group than among their controls: (a) mother aged under 20 at birth of first child, (b) evidence of emotional disturbance, (c) referral of family to hospital social worker, (d) baby9s admission to special care baby unit, (e) recorded concern over the mother9s ability to care for child. Thirty-five of the abused group had two or more of these factors compared with only five of the control group. As these data were collected from information recorded routinely at the maternity hospital, it is possible to identify most abusing families when the child is born. Such identification must lead to a comprehensive assessment of each case followed by constructive preventive action.
Refractory Sprue: Recovery After Removal of Nongluten Dietary Proteins
Authors: ALFRED L. BAKER
Journal: Annals of Internal Medicine (1978)

A 44-year-old woman with diarrhea, weight loss, and a small-bowel biopsy consistent with adult celiac disease failed to improve on a gluten-free diet. Despite in-hospital supervision at two university medical centers and addition of corticosteroid therapy, diarrhea and weight loss continued, resulting in life-threatening nutritional depletion. She was transferred to the University of Chicago and made full nutritional recovery with total parenteral nutrition. Exploratory laparotomy showed no abnormality except the flat intestinal mucosal lesion. Diarrhea recurred when a gluten-free diet was resumed. When the patient ate egg, chicken, or tuna alone, severe diarrhea, hypotension, cyanosis, and shock occurred. When these foods—along with gluten—were eliminated from the diet, the patient returned to oral nutrition and made a full clinical recovery. In patients with refractory sprue deletion of other dietary proteins in addition to gluten, as in the present patient, may be lifesaving.
Dangerous Marine Animals That Bite, Sting, Shock, Are Non-Edible
Authors: Phil Gunby
Journal: JAMA (1981)

The sea may be mankind's ancestral home, but it is good to recall  some other creatures have lived there much longer and more recently. When humans try to return to the depths, even temporarily, as seems increasingly to be the case lately, some of the sea's present inhabitants can—under certain circumstances—make it a painful or even fatal venture.  This is an updated version of a guide originally published 21 years ago. Appropriately, in view of recent horror movies, it begins with the shark, then moves on through other marine creatures that bite, sting, shock, are non-edible. Some seem almost unbelievable, such as the 3-mm Amazon-region catfish known to have penetrated the urethra, vagina, and rectum of humans and other animals. Most of the creatures are depicted in photographs and drawings, including some showing how they might attack and the wounds caused.  Halstead is a physician and, for many of
Pharmacogenetics: detecting sensitive populations.
Authors: P G Shields
Journal: Environmental Health Perspectives (1994)

Risk assessment models strive to predict risks to humans from toxic agents. Safety factors and assumptions are incorporated into these models to allow a margin of error. In the case of cancer, substantial evidence shows that the carcinogenic process is a multistage process driven by the interaction of exogenous carcinogenic exposures, genetic traits, and other endogenous factors. Current risk assessment models fail to consider genetic predispositions that make people more sensitive or resistant to exogenous exposures and endogenous processes. Several cytochrome P450 enzymes, responsible for metabolically activating carcinogens and medications, express wide interindividual variation whose genetic coding has now been identified as polymorphic and linked to cancer risk. For example, a restriction fragment-length polymorphism for cytochrome P4501A1, which metabolizes polycyclic aromatic hydrocarbons, and cytochrome P4502E1, which metabolizes N-nitrosamines and benzene, is linked to lung cancer risk. Cytochrome P4502D6, responsible for metabolizing many clinically important medications, also is linked to lung cancer risk. The frequency for each of these genetic polymorphisms vary among different ethnic and racial groups. In addition to inherited factors for the detection of sensitive populations, determining the biologically effective doses for carcinogenic exposures also should quantitatively and qualitatively enhance the risk assessment process. Levels of carcinogen-DNA adducts reflect the net effect of exposure, absorption, metabolic activation, detoxification, and DNA repair. These effects are genetically predetermined, inducibility notwithstanding. The combination of adduct and genotyping assays provide an assessment of risk that reflects recent exogenous exposure as well as one's lifetime ability to activate and detoxify carcinogens.
Effects of legal termination on subsequent pregnancy.
Authors: J A Richardson, G Dixon
Journal: BMJ (1976)

Two hundred and eleven patients who had undergone vaginal termination and were pregnant again were investigated; 43-2% had become pregnant within one year of termination. The overall fetal loss in the 211 patients was 17-5% compared with 7-5% in a group matched for parity but consisting of patients who were pregnant after a spontaneous abortion. Altogether 4-3% of pregnancies after legal abortion ended as first trimester abortions, 8-5% as second trimester abortions, and 13-7% in premature delivery. Among 11 women whose cervices had been lacerated at the time of legal termination the fetal loss in subsequent pregnancy was 45-5%, and only one pregnancy went beyond 36 weeks. Routine Shirodkar suture may be beneficial when the cervix is known to have been damaged at legal abortion. Several patients had asked that their general practitioner should not be told of their termination, and such patients may not admit their termination during a subsequent pregnancy, which could thus be jeopardised. No evidence was found to suggest that infants of patients with a history of legal termination are small for dates.