tbuckley/cabot-search huggingface dataset:
THE CHEMICAL ESTIMATION OF EPINEPHRINE AND NOREPINEPHRINE IN HUMAN AND CANINE PLASMA. I. A CRITIQUE OF THE ETHYLENEDIAMINE CONDENSATION METHOD 1
Authors: Arthur de T. Valk, Henry L. Price
Journal: Journal of Clinical Investigation (1956)

quent use. It is less specific than the Lund (trihydroxyindole) method, and will detect the presence of dihydroxyphenyl compounds other than E and N (7). The levels of E and N found in normal human plasma by Weil-Malherbe and Bone (1.3 and 5.2 micrograms per liter, respectively) differ from those observed by others (10-12) using essentially the same method, and from the levels obtained by bioassay (13). In view of the fact that a reliable method for estimation of E and N can assume importance in the interpretation of physiological changes in man, it was considered necessary to re-evaluate the EDA method and to compare the results obtained with this technique with those obtained by the trihydroxyindole method. Our results with both dog and human plasma indicate that the EDA method is not specific for N, and may not be so for E.
Looking at vision problems in schoolchildren, infants
Authors: Helene Cole
Journal: JAMA (1985)

A triennial seminar sponsored by Research to Prevent Blindness Inc, New York City, emphasizes work under way at the frontiers of ophthalmology. These reports—emphasizing research to benefit infants and children—are from the most recent seminar, held in Washington, DC (<i>JAMA</i>[MEDICAL NEWS] 1984; 252:3086). <b>Do children with</b>subtle visual abnormalities perform less well academically than their peers who have normal ocular function? In an attempt to answer this question, Eugene Helveston, MD, director of pediatric ophthalmology, Indiana University School of Medicine, Indianapolis, and colleagues evaluated the visual health of 1,910 schoolchildren in the first through third grades. The eye examination included acuity at distance and near, refraction, muscle balance, depth perception, color vision, ocular movements, ocular alignment, light reaction of the pupil, and evaluation of the cornea, lens, and retina. In addition, the children were asked to complete several simple performance tests such as writing their name, copying geometric figures,
Traditions of Folk Medicine in America
Authors: James C. Whorton
Journal: JAMA (1987)

ONE OF the more engrossing medical consultations of the 19th century began when Tom spied Huck ambling down the road swinging a dead cat. Curiosity getting the better of him too, Tom asked the obvious question and learned that what dead cats "is good for" are to "cure warts with." But warts could also, Tom rejoined, be cured with "spunk-water," if one followed his instructions: back up to a stump filled with water, and just at midnight, thrust a hand into the stump while reciting "Barley-corn, Barley-corn, injun-meal shorts, spunk-water, spunk-water, swaller these warts," then rapidly walk away 11 steps, with eyes closed, turn around three times, and finally continue home without speaking to anyone. True, Huck acknowledged, and they could be cured if one split a bean in half, rubbed one side with the blood of the incised wart, buried it at a crossroads at midnight, and then burned
Failure of child safety seat to prevent death.
Authors: D J Ross, P F Gloyns
Journal: BMJ (1986)

Failure of child safety seat to prevent deathSeat belts have increased the protection for the occupants of front seats of cars, and the next, obvious stage is to extend this protection to rear seat passengers and children.'2We report a road traffic accident in which the car driver, restrained by a seat belt, survived but a child in a safety seat died. Case reportA hatchback car collided with a lorry, the forces during the impact causing the car occupants to move directly forward.There was intrusion into both front footwells, but otherwise the passenger compartment remained intact.The driver, who was restrained, sustained a fracture of the femoral shaft as the only major injury.An 18 month old child, weighing 10-5 kg, was strapped into a BS 3254 approved child seat, which was mounted centraly on the rear seat of the
CIRCULATING ESTRADIOL IS A MORE POWERFUL INDEPENDENT RISK FACTOR AND PREDICTOR THAN ADIPONECTIN AND 1,25(OH)2D3 FOR METABOLIC SYNDROME IN MIDDLE-AGED MALE POPULATION
Authors: KaiHung Cheng, Wen-Ter Lai, Chih-Sheng Chu, Shu-Pin Huang, Chia-Chu Liu
Journal: Journal of the American College of Cardiology (2011)
Delhi has overtaken Beijing as the world's most polluted city, report says
Authors: S. Bagcchi
Journal: BMJ (2014)

Air pollution in the Indian capital Delhi has reached a serious level, a new study says—making it the world’s most polluted city, ahead of Beijing. 

The study by the Centre for Science and Environment, a non-government organisation based in New Delhi, found that levels of PM10 (atmospheric particulate matter ≤10 micrometres in size) increased by about 47% in Delhi from 2000 to 2011, whereas in Beijing they decreased by about 40% from 2000 to 2013. “PM10 levels in Delhi are nearly double that of Beijing,” said the study.1

It added, “Both the cities face serious pressures to clean up their air; both have unique challenges. But Delhi seems to lack Beijing’s scale, stringency and frenetic pace …
How to Edit a Scientific Journal
Authors: Harriet S. Meyer
Journal: JAMA (1985)

However many times one has begun a new job, to be the new chief editor of a scientific journal must surely present an overwhelming first day. A short, friendly, practical book on the subject could be the best anodyne. Claude Bishop, editor in chief of the National Research Council of Canada journals, has written a book that fits the bill. Experienced editors may have the uncanny sensation that Bishop was looking over their shoulders during its preparation. As the cover notes, the tone is sympathetic, and the author writes with humor, including delightful examples of correspondence and some apt visual aids. Bishop covers the basics of journal editing, beginning with the editor, then editorial boards, review of manuscripts, ethics, manuscript records, and printing and publishing. Advice on such entities as the "offbeat submission," the "appropriate stage" in one's career to become an editor," and "nonworking [lazy] editorial boards" is eminently
Transient sensitization to house-dust mites: a studv on the influence of mite exposure and six
Authors: M. Wickman, J. Korsgaard
Journal: Allergy (1996)

This study aimed to evaluate the prognosis of a previous positive skin test to house‐dust mites (HDM) in relation to environmental exposure. A total of 115 children. 50 from Stockholm and 65 from northern Sweden, all with a previous (average 2.5 years) positive Phazet (Pharmacia AB, Uppsala, Sweden) skin prick test (SPT) to extracts of Dermatophagoides pteronyssinus (Dpt ) and/or D. farinae (Df ) were included. Dust samples were collected from the children's mattresses, and the total ( Dpt, Df, and D. microceras [Dm] ) amount of major mite allergen was measured by ELISA (50 children) and expressed as microgram allergen per gram of dust, or was measured by microscopy (65 children). The results of microscopic mite counts were transformed to approximate allergen levels as 2 μg equals 100 mites per gram of dust. Of 115 originally SPT‐positive children, only 48 (48%) remained positive at retest, while the majority (58%) were SPT negative after 2 years. Among the 67 converted children, 11 were still exposed to mite allergen, but only to low concentrations (only one converted child being exposed above the suggested threshold level [TLV] of 2 pg/g), compared to 15/48 children still SPT positive who were exposed above the TLV. This shows that continued mite exposure is a major risk factor (OR=30, CI 4.8–184) for continued positive SPT to HDM. A minor risk factor for continued sensitization was sex, boys having a higher risk than girls (OR = 2.2, CI 1.0–4.8). In conclusion. a surprisingly high rate of SPT conversion occurred, mainly as a result of a favorable indoor environment with low exposure to HDM and, to a lesser degree, as a result of sex. The present results support the view that the risk level of exposure is 2 μg mite allergen per gram of dust.
Top-Accessed Article: Topical Rapamycin
Authors: Anita N. Haggstrom, Stephen E. Wolverton
Journal: JAMA Dermatology (2013)

In conclusion, scalp dysesthesia is a syndrome characterized primarily by scalp burning or pruritus in the absence of any other unusual physical examination findings and may be associated with cervical spine disease.In this study, 14 of 15 of patients with scalp dysesthesia also had abnormal cervical spine images.The pathogenesis may be related to chronic muscle tension placed on the pericranial muscles and scalp aponeurosis secondary to the underlying cervical spine disease and is likely unrelated to psychiatric disorders.Four patients reported improvement in symptoms with gabapentin, but the optimal dosage and route of administration need to be studied.Larger, prospective studies are needed to further characterize the pathogenesis of scalp dysesthesia and to determine the most efficacious treatments.
Additional Factors That Could Improve Cost-Effectiveness of Pharmacogenetic-Guided Dosing in Warfarin Therapy
Authors: Benjamin P. Geisler
Journal: Annals of Internal Medicine (2009)

Letters7 July 2009Additional Factors That Could Improve Cost-Effectiveness of Pharmacogenetic-Guided Dosing in Warfarin TherapyBenjamin P. Geisler, MD and Jeffrey K. Levin-Scherz, MD, MBABenjamin P. Geisler, MDFrom Harvard School of Public Health, Boston, MA 02115.Search for more papers by this author and Jeffrey K. Levin-Scherz, MD, MBAFrom Harvard School of Public Health, Boston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-1-200907070-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We were surprised that Eckman and colleagues (1) found through comprehensive modeling that genotyping before warfarin therapy instead of standard care without genotyping is not cost effective compared with other, well-accepted medical interventions.We suggest that additional factors may improve the cost-effectiveness of warfarin genotyping. For example, if patients with a short-term warfarin indication (that is, uncomplicated deep venous thrombosis) had their genotype recorded in an interoperable electronic health record, this test would not need to be repeated before subsequent warfarin use. Because genotype testing is the largest component of costs, additional benefit would accrue with limited ...Reference1. Eckman MH, Rosand J, Greenberg SM, Gage BF. Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation. Ann Intern Med. 2009;150:73-83. [PMID: 19153410] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Benjamin P. Geisler, MD; Jeffrey K. Levin-Scherz, MD, MBAAffiliations: From Harvard School of Public Health, Boston, MA 02115.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness of Using Pharmacogenetic Information in Warfarin Dosing for Patients With Nonvalvular Atrial Fibrillation Mark H. Eckman , Jonathan Rosand , Steven M. Greenberg , and Brian F. Gage Additional Factors That Could Improve Cost-Effectiveness of Pharmacogenetic-Guided Dosing in Warfarin Therapy Mark H. Eckman , Jonathan Rosand , Steven M. Greenberg , and Brian F. Gage Metrics 7 July 2009Volume 151, Issue 1Page: 71KeywordsConflicts of interestDeep vein thrombosisElderlyElectronic medical recordsFallsGenotypingHemorrhage ePublished: 7 July 2009 Issue Published: 7 July 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effect of Thromboxane A <sub>2</sub> Blockade on Clinical Outcome and Restenosis After Successful Coronary Angioplasty
Authors: Michael P. Savage, Sheldon Goldberg, Alfred A. Bove, Ezra Deutsch, George Vetrovec, Robert G. Macdonald, Theodore Bass, James R. Margolis, Hall B. Whitworth, Andrew Taussig, John W. Hirshfeld, Michael Cowley, James A. Hill, Ronald G. Marks, David L. Fischman, Eileen Handberg, Howard Herrmann, Carl J. Pepine
Journal: Circulation (1995)

Background Antithromboxane therapy with aspirin reduces acute procedural complications of coronary angioplasty (PTCA) but has not been shown to prevent restenosis. The effect of chronic aspirin therapy on long-term clinical events after PTCA is unknown, and the utility of more specific antithromboxane agents is uncertain. The goal of this study was to assess the effects of aspirin (a nonselective inhibitor of thromboxane A 2 synthesis) and sulotroban (a selective blocker of the thromboxane A 2 receptor) on late clinical events and restenosis after PTCA. Methods and Results Patients (n=752) were randomly assigned to aspirin (325 mg daily), sulotroban (800 mg QID), or placebo, started within 6 hours before PTCA and continued for 6 months. The primary outcome was clinical failure at 6 months after successful PTCA, defined as (1) death, (2) myocardial infarction, or (3) restenosis associated with recurrent angina or need for repeat revascularization. Neither active treatment differed significantly from placebo in the rate of angiographic restenosis: 39% (73 of 188) in the aspirin-assigned group, 53% (100 of 189) in the sulotroban group, and 43% (85 of 196) in the placebo group. In contrast, aspirin therapy significantly improved clinical outcome in comparison to placebo ( P =.046) and sulotroban ( P =.006). Clinical failure occurred in 30% (49 of 162) of the aspirin group, 44% (73 of 166) of the sulotroban group, and 41% (71 of 175) of the placebo group. Myocardial infarction was significantly reduced by antithromboxane therapy: 1.2% in the aspirin group, 1.8% in the sulotroban group, and 5.7% in the placebo group ( P =.030). Conclusions Thromboxane A 2 blockade protects against late ischemic events after angioplasty even though angiographic restenosis is not significantly reduced. While both aspirin and sulotroban prevent the occurrence of myocardial infarction, overall clinical outcome appears superior for aspirin compared with sulotroban. Therefore, aspirin should be continued for at least 6 months after coronary angioplasty.
Splice Variants Reveal the Region Involved in Oxygen Sensing by Recombinant Human L-Type Ca <sup>2+</sup> Channels
Authors: Ian M. Fearon, Gyula Varadi, Sheryl Koch, Idit Isaacsohn, Stephen G. Ball, Chris Peers
Journal: Circulation Research (2000)

Regulation of vascular smooth muscle Ca 2+ channels by oxygen tension contributes importantly to hypoxic vasodilatation. We previously described the inhibitory effects of hypoxia on the recombinant human cardiac L-type Ca 2+ channel α 1C subunit (hHT isoform) expressed in HEK 293 cells. We now demonstrate that hypoxia inhibits only one of the three naturally occurring splice variants of this channel that differ only in the C-terminal domain, permitting identification of a 71-amino acid insert in the C-terminal region of the channel that confers oxygen sensitivity. Selective restriction of the spliced insert allowed determination of a 39-amino acid region essential for oxygen sensing. This represents the first identification of the structural region of an ion channel required for sensing changes in oxygen tension.
Diazoxide and hypotension.
Authors: L H Sevitt, D K Peters
Journal: BMJ (1971)

specific infection, seems a convincing argu- ment for routine testing by general practi- tioners of the sexually-active women patients on their lists.Even if a large majority of women examined should prove to be free from any form of genital infection, routine screening programmes-wherever carried out -offer the only means of eventually controlling sexually-transmitted disease.-Weare, etc.,
Clinical outcome after sex-mismatched allogeneic stem cell transplantation from human lymphocyte antigen-identical sibling donors: influence of stem cell source
Authors: D Gallardo, A Pérez-García, R de la Cámara, A Iriondo, A Jiménez-Velasco, A Torres, S Brunet, Á Urbano-Ispizúa, C Vallejo, M Encuentra, D Caballero, I Espigado, D Serrano, C Barrenetxea, J M Ribera, J de la Rubia
Journal: Leukemia (2006)
Mortality and morbidity among the old.
Authors: E Grundy
Journal: BMJ (1984)

and prolonged rehabilitation.The estimated overall savings on accident costs from the first year of seat belt legislation is of the order of £120 million-enough to finance the running of four whole health districts for one year.7We need to remember, however, that wearing seat belts by all occupants of motorcars is only a form of secondary prevention in that it reduces the severity of injury after.the accident has happened.More attention needs to be paid to primary prevention-in the form of improving the behaviour of drivers and especially in discouraging them from drinking and driving.Members ofParliament welcome expert advice and informed comment, especially when these are based on sound evidence.The doctors' lobby was an important factor in the first stage of seat belt legislation.Should the BMA now adopt the next step as part of its policy?And should doctors lobby their own local members of Parliament to prompt them to support the early day motion?
The Role of Methotrexate in Osteosarcoma
Authors: J. L. Grem, S. A. King, R. E. Wittes, B. Leyland-Jones
Journal: JNCI Journal of the National Cancer Institute (1988)

High-dose methotrexate (MTX) is one of the agents currently used in intensive adjuvant chemotherapy regimens for nonmetastatic osteosarcoma. To elucidate the role of high-dose MTX in this disease, we present the history of trials conducted with MTX from the first single-agent studies through progressively complex combination regimens. With this background, some of the basic dissues concerning MTX therapy in osteosarcoma are discussed. [J Natl Cancer Inst 1988;80:626–656]
Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site
Authors: Nathan J. Alves, Matthew M. Champion, Jared F. Stefanick, Michael W. Handlogten, Demetri T. Moustakas, Yunhua Shi, Bryan F. Shaw, Rudolph M. Navari, Tanyel Kiziltepe, Basar Bilgicer
Journal: Biomaterials (2013)
Lymphocyte responses to DR1/4 restricted peptides in rheumatoid arthritis.
Authors: M.A. Skinner, L Watson, A Geursen, P.L. Tan
Journal: Annals of the Rheumatic Diseases (1994)

OBJECTIVE--To determine whether analog and unrelated DR1/4 binding peptides alter DR1/4 restricted responses of peripheral blood lymphocytes (PBL) from patients with rheumatoid arthritis (RA). METHODS--PBL from 25 patients with RA and 12 healthy controls were cultured with DR1/4 restricted peptides of the influenza haemagglutinin, amino acids 307-319 (HA) and matrix proteins, amino acids 17-29 (IM). Responses were determined by 3H-thymidine uptake proliferation assays and limiting dilution analysis. Competitor peptides were analogs HA-R312 and HA-K313 differing from HA by one amino acid at the 312 or 313 position respectively or unrelated peptides which bind to DR1/4. RESULTS--The responses of eight patients with RA to the two stimulatory influenza peptides did not differ significantly from controls and this was confirmed by the frequency estimate of T cells in PBL which responded to HA (mean frequency: 1 in 9.0 x 10(4), n = 5, in DR1/4+ RA patients, 1 in 7.6 x 10(4), n = 5, in DR1/4+ healthy controls). DR1/4 binding analogs of the HA peptide inhibited HA specific peptide responses of PBL from patients with RA and controls. Inhibition was also detected with unrelated peptides which bind to DR1/4 but to which the individual did not respond. CONCLUSION--Similar responses to two DR1/4 restricted peptides were observed in patients with RA and controls. Both antigen analog- and unrelated peptide-major histocompatibility complexes (MHC) can result in the inhibition of antigen specific responses in multi-clonal human lymphocyte populations. However, an analog peptide may be stimulatory in some individuals. These results provide some initial data for the development of a rational approach to MHC-specific immunomodulation in rheumatoid arthritis.
Longitudinal Change in the BODE Index Predicts Mortality in Severe Emphysema
Authors: Fernando J. Martinez, MeiLan K. Han, Adin-Cristian Andrei, Robert Wise, Susan Murray, Jeffrey L. Curtis, Alice Sternberg, Gerard Criner, Steven E. Gay, John Reilly, Barry Make, Andrew L. Ries, Frank Sciurba, Gail Weinmann, Zab Mosenifar, Malcolm DeCamp, Alfred P. Fishman, Bartolome R. Celli
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Rationale: The predictive value of longitudinal change in BODE (Body mass index, airflow Obstruction, Dyspnea, and Exercise capacity) index has received limited attention. We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients.Objectives: To determine how the mBODE score changes in patients with lung volume reduction surgery versus medical therapy and correlations with survival.Methods: Clinical data were recorded using standardized instruments. The mBODE was calculated and patient-specific mBODE trajectories during 6, 12, and 24 months of follow-up were estimated using separate regressions for each patient. Patients were classified as having decreasing, stable, increasing, or missing mBODE based on their absolute change from baseline. The predictive ability of mBODE change on survival was assessed using multivariate Cox regression models. The index of concordance was used to directly compare the predictive ability of mBODE and its separate components.Measurements and Main Results: The entire cohort (610 treated medically and 608 treated surgically) was characterized by severe airflow obstruction, moderate breathlessness, and increased mBODE at baseline. A wide distribution of change in mBODE was seen at follow-up. An increase in mBODE of more than 1 point was associated with increased mortality in surgically and medically treated patients. Surgically treated patients were less likely to experience death or an increase greater than 1 in mBODE. Indices of concordance showed that mBODE change predicted survival better than its separate components.Conclusions: The mBODE demonstrates short- and intermediate-term responsiveness to intervention in severe chronic obstructive pulmonary disease. Increase in mBODE of more than 1 point from baseline to 6, 12, and 24 months of follow-up was predictive of subsequent mortality. Change in mBODE may prove a good surrogate measure of survival in therapeutic trials in severe chronic obstructive pulmonary disease.Clinical trial registered with www.clinicaltrials.gov (NCT 00000606).
Multidetector Computed Tomography Myocardial Perfusion Imaging During Adenosine Stress
Authors: Richard T. George, Caterina Silva, Marco A.S. Cordeiro, Anthony DiPaula, Douglas R. Thompson, William F. McCarthy, Takashi Ichihara, Joao A.C. Lima, Albert C. Lardo
Journal: Journal of the American College of Cardiology (2006)
Comparison of inflammatory responses to genetically engineered hypoallergenic derivatives of the major birch pollen allergen Bet v 1 and to recombinant Bet v 1 wild type in skin chamber fluids collected from birch pollen–allergic patients
Authors: A Nopp, G Halldén, J Lundahl, E Johansson, S Vrtala, R Valenta, R Grönneberg, M Van Hage-Hamsten
Journal: Journal of Allergy and Clinical Immunology (2000)
A RANDOMIZED TRIAL OF REMOTE ISCHEMIC POSTCONDITIONING DURING PERCUTANEOUS CORONARY INTERVENTIONS – THE RIP-PCI TRIAL
Authors: Shahar Lavi, Sabrina D'Alfonso, Nour Abu-Romeh, Sabrina Wall, Mistre Alemayehu, Pallav Garg, Patrick Teefy, Pantelis Diamantouros, George Jablonsky, Anthony Camuglia, Ronit Lavi
Journal: Journal of the American College of Cardiology (2014)