Trimethoprim-Sulfamethoxazole and Granulocytopenia
Authors: KAMAL M. BAKRI
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 March 1982Trimethoprim-Sulfamethoxazole and GranulocytopeniaKAMAL M. BAKRI, LARRY P. WASSERKAMAL M. BAKRISearch for more papers by this author, LARRY P. WASSERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-381 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article on prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukemia by Dekker and colleagues (1). We agree with the conclusion that more studies are needed before trimethoprim-sulfamethoxazole is used universally as a prophylactic antimicrobial drug in granulocytopenic patients (1-4). But we wonder if one more study like this, which does show a significant statistical difference favoring trimethoprim-sulfamethoxazole treatment to infection in granulocytopenic patients, adds anything to clear the existing confusion. Because this study, although randomized, had only a few patients in each group and also used...References1 DEKKERROZENBERG-ARSKASIXMAVERHOEF AMJJ. Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia. Ann Intern Med. 1981;95:555-9. LinkGoogle Scholar2. GURWITHBRUNTONLANKHARDINGRONALD MSBGA. A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients. Am J Med. 1979;66:248-56. CrossrefMedlineGoogle Scholar3. WADESCHIMPFFHARGADONFORTNERYOUNGWIERNIK JSMCVP. A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in prevention of infection in acute leukemia. N Engl J Med. 1981;304:1057-62. CrossrefMedlineGoogle Scholar4. ENNOCATOVSKYDARRELLGOLDMANHOWSGALTON ADJJJD. Cotrimoxazole for prevention of infection in acute leukemia. Lancet. 1978;2:395-7. CrossrefMedlineGoogle Scholar5. GOLDEBERSCHQUAN DNS. Trimethoprim and sulfamethoxazole inhibition of hematopoiesis in vitro. Br J Haematol. 1978;40:363-7. CrossrefMedlineGoogle Scholar1. WADEDE JONGHNEWMANWIERNIKSCHIMPFF JCKPS. A comparison of trimethoprim/sulfamethoxazole to nalidixic acid: selective decontamination as infection prophylaxis during granulocytopenia. 21st Interscience Conference on Antimicrobial Agents and Chemotherapy. 1981;796. Abstract. Google Scholar2. GOLDEBERSCHQUAN DNS. Trimethoprim and sulfamethoxazole inhibition of hematopoiesis in vitro. Br J Haematol. 1978;40:363-7. CrossrefMedlineGoogle Scholar3. KOBRINSKYRAMSAY NN. Acute megaloblastic anemia induced by high-dose trimethoprim-sulfamethoxazole. Ann Intern Med. 1981;94:780-1. LinkGoogle Scholar4. MAGEEO'SULLIVANMCCANN FHS. Megaloblastosis and low-dose trimethoprim-sulfamethoxazole. Ann Intern Med. 1981;95:657. Letter. LinkGoogle Scholar5. RIVARDMOMPARLERMOMPARLER GLR. Effects of trimethoprim on leukaemic cells in vitro. Br J Haematol. 1981;47:221-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center Chicago Medical School North Chicago, IL 60064 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1982Volume 96, Issue 3Page: 381-382KeywordsAcute myeloid leukemiaAmphotericinAntimicrobialsDrugs Issue Published: 1 March 1982 PDF DownloadLoading ...