tbuckley/cabot-search huggingface dataset:
A Risk-adapted Study of Cisplatin and Etoposide, with or Without Ifosfamide, in Patients with Metastatic Seminoma: Results of the GETUG S99 Multicenter Prospective Study
Authors: Karim Fizazi, Rémi Delva, Armelle Caty, Christine Chevreau, Pierre Kerbrat, Frederic Rolland, Frank Priou, Lionnel Geoffrois, Olivier Rixe, Philippe Beuzeboc, Jean-Pierre Malhaire, Stephane Culine, Marie-Stephanie Aubelle, Agnes Laplanche
Journal: European Urology (2013)
Histidine Treatment of Peptic Ulcer
Authors: J. M. Anderson
Journal: BMJ (1936)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Histidine Treatment of Peptic Ulcer Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
The use of polymeric platinum(IV) prodrugs to deliver multinuclear platinum(II) drugs with reduced systemic toxicity and enhanced antitumor efficacy
Authors: Haihua Xiao, Haiqin Song, Yu Zhang, Ruogu Qi, Rui Wang, Zhigang Xie, Yubin Huang, Yuxin Li, Yin Wu, Xiabin Jing
Journal: Biomaterials (2012)
Implementation of an Outpatient Electronic Health Record and Emergency Department Visits, Hospitalizations, and Office Visits Among Patients With Diabetes
Authors: Mary Reed, Jie Huang, Richard Brand, Ilana Graetz, Romain Neugebauer, Bruce Fireman, Marc Jaffe, Dustin W. Ballard, John Hsu
Journal: JAMA (2013)

The US federal government is spending billions of dollars in physician incentives to encourage the meaningful use of electronic health records (EHRs).Although the use of EHRs has potential to improve patient health outcomes, the existing evidence has been limited and inconsistent.OBJECTIVE To examine the association between implementing a commercially available outpatient EHR and emergency department (ED) visits, hospitalizations, and office visits for patients with diabetes mellitus.DESIGN, SETTING, AND POPULATION Staggered EHR implementation across outpatient clinics in an integrated delivery system (Kaiser Permanente Northern California) between 2005 and 2008 created an opportunity for studying changes associated with EHR use.Among a population-based sample of 169 711 patients with diabetes between 2004 and 2009, we analyzed 4 997 585 person-months before EHR implementation and 4 648 572 person-months after an EHR was being used by patients' physicians. MAIN OUTCOMES AND MEASURESWe examined the association between EHR use and unfavorable clinical events (ED visits and hospitalizations) and office visit use among patients with diabetes, using multivariable regression with patient-level fixed-effect analyses and adjustment for trends over time. RESULTSIn multivariable analyses, use of the EHR was associated with a statistically significantly decreased number of ED visits, 28.80 fewer visits per 1000 patients annually (95% CI, 20.28 to 37.32), from a mean of 519.12 visits per 1000 patients annually without using the EHR to 490.32 per 1000 patients when using the EHR.The EHR was also associated with 13.10 fewer hospitalizations per 1000 patients annually (95% CI, 7.37 to 18.82), from a mean of 251.60 hospitalizations per 1000 patients annually with no EHR to 238.50 per 1000 patients annually when using the EHR.There were similar statistically significant reductions in nonelective hospitalizations (10.92 fewer per 1000 patients annually) and hospitalizations for ambulatory care-sensitive conditions (7.08 fewer per 1000 patients annually).There was no statistically significant association between EHR use and office visit rates.CONCLUSIONS AND RELEVANCE Among patients with diabetes, use of an outpatient EHR in an integrated delivery system was associated with modest reductions in ED visits and hospitalizations but not office visit rates.Further studies are needed to quantify the association of EHR use with changes in costs.
Medical Ventures and the University: New Values and New Validities
Authors: Philip C. Anderson
Journal: JAMA (1967)

Readers who seek the crucial questions of modern medical education and the direct answers to them will be disappointed with this 210page account of the 13th AAMC institute. The contributors recognize the inevitability of major social change, they agree that the dilemmas of the medical school are early evidences of the general problems the universities will face, and they proclaim the great importance of reforming the anachronistic character of our medical schools but, except for a few comments, such as those by Colin MacLeod, John Millis, or Lowell Coggeshall, I find no sense of the missions just completed or of solid battle plans. The deans seem almost willing to support a major revolution against the status quo, but not quite, and not now. Vagueness is commonplace in this book, and the themes are worthy of that great equivocator, Polonius. It is difficult to serve yet not be subservient; or to
Plasmacytoid dendritic cells regulate the magnitude of an autoimmune response through expansion of suppressive monocytes
Authors: M Ioannou, T Alissafi, L Boon, S Deraos, J Matsoukas, D Boumpas, P Verginis
Journal: Annals of the Rheumatic Diseases (2010)

Myeloid-derived suppressor cells (MDSCs) are essential for the suppression of multiple immune responses. However, the mechanisms that regulate their expansion and suppressive function remain largely unknown. We demonstrate here that depletion of plasmacytoid dendritic cells (pDCs) resulted …
A nanny's stamina
Authors: Elizabeth Davies
Journal: BMJ (2004)

When I started as a senior house officer on the unit she was practically mute: the effort of speaking was immense, she could give none of the usual conversational cues, and it was difficult to maintain such a one sided encounter for long. She sat on the ward throughout the day, eschewing the group activities, her face conveying silent despair. “I just can't do anything,” she would manage. Later she recalled how she had felt the predicament of others trying to draw her out, but when I asked what she felt her attendants should do in that situation, she replied, “You can't, there's nothing anyone can do. When someone's like that you just have to leave them.” None the less, I went every day to see her, asking her how she was and taking blood to check …
Angiocardiographic Demonstration of Occlusive Auricular Thrombi in Dogs
Authors: JOHN L. READ, LEWIS H. BOSHER, FELIX FERRARU, SAMUEL RICHMAN, RENO R. PORTER
Journal: Circulation (1955)

Simulated occlusive auricular thrombi were produced in six dogs by surgically invaginating the left auricular appendage. Angiocardiographic studies were performed in five of the dogs and in each case revealed these thrombi as clear cut filling defects. The significance and clinical application of these observations is discussed.
Hereditary spherocytosis with band 3 deficiency. Association with a nonsense mutation of the band 3 gene (allele Lyon), and aggravation by a low-expression allele occurring in trans (allele Genas)
Authors: N Alloisio, P Maillet, G Carre, P Texier, A Vallier, F Baklouti, N Philippe, J Delaunay
Journal: Blood (1996)
Improvement of anaemia in haemodialysed patients after viral or toxic hepatic cytolysis.
Authors: P Simon, A Meyrier, T Tanquerel, K S Ang
Journal: BMJ (1980)

Thirty patients receiving haemodialysis, including two who had undergone bilateral nephrectomy, showed significant increases (p less than 0.001) in packed cell volume, haemoglobin concentration, and reticulocyte count during an episode of viral or toxic liver cytolysis. In 19 cases the episode lasted a mean of 5.0 +/- SD 2.9 months and was accompanied by improved haematological values for a mean of 12.0 +/- 6.0 weeks. Of the remaining patients, in whom the episode lasted a mean of 8.0 +/- 3.5 months (p less than 0.02), seven showed continued improvement a mean of 30.0 +/- 16.0 weeks after cytolysis. In eight patients in this group there was an apparent correlation between persistently increased haemoglobin concentrations and biopsy evidence of chronic hepatitis. The findings suggest that the reduction in anaemia resulted from enhanced red-cell production mediated by secretion of erythropoietin from regenerating liver cells. If confirmed this might have important implications for the treatment of anaemia in chronic renal insufficiency.
Does Bone Marrow Transplantation Confer a Normal Life Span?
Authors: E. Donnall Thomas
Journal: New England Journal of Medicine (1999)

In the 1950s and 1960s, many bone marrow transplantations were attempted in terminally ill patients with leukemia or aplastic anemia without success, except in a few patients who had identical-twin donors. The modern era of marrow transplantation began at the end of the 1960s with the development of knowledge about the HLA system and the development of tissue typing. In the 1970s, many patients began to survive the toxic effects of the early preparative regimens and acute graft-versus-host disease. Survival with a successful graft for more than 100 days made it possible to study relapse and chronic graft-versus-host disease. These . . .
Swallowed Foreign Bodies
Authors: Paul M. Walstad
Journal: JAMA (1962)

<h3>To the Editor:—</h3> Reference is made to the recent article "Foreign Bodies in the Gastrointestinal Tract" by Dr. Watson W. Eldridge (<i>JAMA</i><b>178</b>:665-667 [Nov. 11] 1961), in which he states: "A foreign body in the gastrointestinal tract can almost always be successfully treated without surgical intervention. The facts of this not-too-uncommon situation do not seem to be very widely known. They should be." It is interesting to note that these facts regarding foreign bodies and nonsurgical intervention were well known centuries ago by Galen. In Book Three,<i>On Natural Faculties</i>, written in the second century A.D., he writes: "There are a great many people who frequently swallow large quantities of big fruit stones; one person who was holding a gold ring in his mouth, inadvertently swallowed it; another swallowed a coin, and various people have swallowed various hard and indigestible objects; yet all these people easily passed by the
The Heart: Physiology and Metabolism
Authors: P. B GARLICK
Journal: Cardiovascular Research (1992)

Journal Article The Heart: Physiology and Metabolism Get access PAMELA B GARLICK PAMELA B GARLICK Second Edition. Lionel H Opie (Consultants Bernard Swynghedauw, Heinrich Taegtmeyer, J Caspar Rũegg, and Edward Carmeliet) (Pp 527; $90). Raven Press, New York, 1991. ISBN 0-88167-751-5. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 1, January 1992, Page 85, https://doi.org/10.1093/cvr/26.1.85 Published: 01 January 1992
Steroid-refractory Neonatal Eosinophilic Pneumonia Responsive to Cyclosporin A
Authors: RONALD L. MORTON, LAWRENCE R. SHOEMAKER, NEMR S. EID
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Idiopathic neonatal eosinophilic pneumonia is extremely rare. We report an infant who presented with tachypnea and interstitial infiltrates on chest radiograph at age 2 wk. Lung biopsy revealed perivascular and interstitial eosinophils. Despite initial improvement, the patient's condition became resistant to corticosteroids, cromolyn, and intravenous gamma globulin. After treatment with cyclosporin A his symptoms resolved.
CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity
Authors: Keiichi Sakakibara, Naoya Saito, Takuji Sato, Atsushi Suzuki, Yoko Hasegawa, Jonathan M. Friedman, Donald W. Kufe, Daniel D. VonHoff, Tadahiko Iwami, Takumi Kawabe
Journal: Blood (2011)
Elevated Blood Pressure Levels in Adolescents, Evans County, Georgia
Authors: Siegfried Heyden
Journal: JAMA (1969)

Hypertension in adolescents is still a debatable subject in regard to prognosis. Conclusions on the significance of "prehypertension" have been divided and no long-term follow-up has been reported in a representative population. In a group of 435 adolescents of the Evans County Epidemiologic Study, 11% had hypertension (≥140 and/ or ≥90 mm Hg) in 1961. After seven years, 30 of this group were reevaluated. Two deaths from cerebral hemorrhage occurred. One patient has hypertensive heart disease; sustained hypertension with cardiovascular and cerebrovascular symptoms developed in three more. Five were found to have asymptomatic sustained hypertension. Seven more had hypertension not reaching levels of sustained hypertension (≥160 and/or ≥95 mm Hg). Twelve have become normotensive. The most impressive associated finding was overweight and subsequent weight gain in eventual sustained hypertensives.
Suspicions of female infidelity predict men's partner-directed violence
Authors: Farnaz Kaighobadi, Todd K. Shackelford
Journal: Behavioral and Brain Sciences (2009)

Abstract Archer's argument regarding sex differences in partner violence rests on a general account of between-sex differences in reproductive strategies and in social roles. However, men's partner-directed violence often is predicted by perceived risk of female infidelity. We hypothesize that men's partner-directed violence is produced by psychological mechanisms evolved to solve the adaptive problem of paternity uncertainty.
TWO ACCIDENTAL DEATHS FROM UNUSUAL PENETRATING WOUNDS
Authors: Edward H. Hatton
Journal: JAMA (1918)

Death as the result of either external or internal hemorrhage is a rather common accident. Occasionally these accidents are associated with unusual features which justify reporting. <h3>Case 1.</h3> —A section hand employed driving spikes with a large steel hammer was struck on the left side of the neck by a steel fragment from the hammer he was using. There was some hemorrhage from the external wound, but more blood was coughed up, apparently from the air passages. The man was put into an ambulance and hurried to the nearest hospital, but died before it was reached, twenty minutes after the accident occurred. At the necropsy there was found a shallow incised wound just over the lower border of the mandible on the left side, five-eighths inch long, and a smaller wound five-eighths inch to the left of the midline and one-half inch below the prominence of the thyroid cartilage. The
The Factor of Infection in Heart Failure
Authors: F. J. Flint
Journal: BMJ (1954)

INFECTIONS RDITISHRNAL_Acute respiratory failure with increasing anoxaemia, hypercapnia, and acidaemia is responsible for the dis- tinctive clinical picture observed during exacerbation of infection in the chronic bronchitic and emphysematous subject: headache, raised intracranial pressure, papill- oedema, mental confusion, hallucinations, sweating, myoclonic jerking, iricreased cardiac output, pulmonary hypertension, and congestive cardiac failure.Mortality from " bronchitis" has not declined in the last 10 years despite antibiotic therapy: respiratory failure may be a partial explanation of this phenomenon.I wish to thank Dr. C. M.
Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons.
Authors: M B Sztein, P S Steeg, H M Johnson, J J Oppenheim
Journal: Journal of Clinical Investigation (1984)

The in vitro regulation of adult human monocyte DR antigen expression was studied. Normally about 75% of freshly obtained human peripheral blood monocytes express DR antigens as determined by anti-DR and complement-mediated cytotoxicity assays. DR expression on monocytes in unfractionated peripheral blood mononuclear cell cultures persisted to variable degrees for up to 5 d of incubation. However, when the mononuclear cells were thoroughly depleted of nonadherent cells, cultured monocytes consistently exhibited progressively decreased DR expression over 2-5 d of incubation. Readdition of nonadherent cells to the adherent cell population prevented or delayed this decrease in monocyte DR antigen expression. Thus, monocyte DR expression diminished markedly during in vitro incubation; however, the presence of nonadherent cells somehow interfered with this process. In other experiments, peripheral adherent monocytes, which had been cultured for 2-3 d to reduce their DR expression, could be induced to reexpress DR antigens after 2 d of incubation with unpurified lymphokine-containing culture supernatants, recombinant human interferon-alpha, or recombinant human gamma interferon (IFN-gamma). The reinduction of DR expression on human monocytes by lymphokines was abrogated by an antiserum produced to the synthetic N-terminal amino acids of human IFN-gamma, indicating that IFN-gamma is the active mediator in the lymphokine-containing preparations. Monocytes cultured with lymphokines or recombinant interferons also could initiate a significantly greater mixed lymphocyte response than control monocytes. Thus, IFN-gamma-containing lymphokines and recombinant interferons are required to induce human monocyte DR expression and accessory cell capacity in vitro, since in their absence monocytes become DR antigen-deficient. Finally, incubation of unfractionated human mononuclear cells with anti-human IFN-gamma also promoted the loss of monocyte DR expression. These findings suggest that resting lymphocytes are probably capable of producing sufficient IFN-gamma in vitro to result in the maintenance of the monocyte DR phenotype.
Effect of wheat bran on weight of stool and gastrointestinal transit time: a meta analysis
Authors: S. A Muller-Lissner
Journal: BMJ (1988)

Twenty original papers that reported on the effect of wheat bran on large bowel function were analysed. Bran increased the stool weight and decreased the transit time in each study in healthy controls and in patients with the irritable bowel syndrome, with diverticula, and with chronic constipation. Statistical evaluation of the data showed, however, that constipated patients had lower stool output and slower transit whether or not they had taken bran, and they responded less well to bran treatment than controls. From these data it is concluded that bran can be expected to be only partially effective in restoring normal stool weight and transit time in patients who are constipated.
STUDIES IN EXPERIMENTAL EXTRACORPOREAL THROMBOSIS
Authors: Leonard G. Rowntree, Takuji Shionoya
Journal: The Journal of Experimental Medicine (1927)

A new method has been described for the study in vivo of thrombus formation in blood circulating extracorporeally in an artificial loop. This method permits of control of many factors, and hence of intensive study of thrombus formation under many and varied conditions. It admits of separate study of the formation of white thrombi and of the deposition of fibrin, which may apparently be independent processes.
Susceptibility to irritants: role of barrier function, skin dryness and history of atopic dermatitis
Authors: R.A. TUPKER, J. PINNAGODA, P.J. COENRAADS, J.P. NATER
Journal: British Journal of Dermatology (1990)

The susceptibility of the skin to various irritants was investigated with the aim of determining the role of the barrier function of the stratum corneum, skin dryness and whether a history of atopic dermatitis (AD) was a factor. The transepidermal water loss (TEWL) was measured using an evaporimeter and skin hydration using a Corneometer and by visual scoring. The group with a history of AD (n= 20) had a lower pre-exposure barrier function and a higher TEWL value following irritant exposure than the group with a history of allergic contact dermatitis (n= 18) and a control group (n= 18). Clinically dry skin was more susceptible than normal skin, though no difference was noted in the pre-exposure barrier function. The increased susceptibility to irritants in those with a past history of AD was probably due to impaired barrier function. The increased susceptibility to irritants in those with a past history of AD was probably due to impaired barrier function and/or the presence of a dry skin.
The Acute Cardiac Risk of Strenuous Exercise
Authors: Larry W. Gibbons
Journal: JAMA (1980)

During a 65-month period, 2,935 adults (mean age, 37 years) kept computer logs of amount and intensity of exercise performed. A total of 374,798 person-hours of exercise, including 2,726,272 km or running and walking, was recorded. Two cardiac events and no deaths occurred during this period. Considered in age-specific categories, the maximum risk estimates (MREs) consistent with these data (upper 95% confidence limits) range from 0.3 to 2.7 events per 10,000 person-hours of exercise for men and 0.6 to 6.0 events per 10,000 person-hours for women. The MREs for women were higher because there were fewer women in the study. If exercise were performed three time per week for 30 minutes per session for a year, these results would lead to MREs from .002 to .027 events per person-year for men and .005 to .05 events per person-year for women. Actual risks are likely to be lower.
Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma
Authors: Kojiro Matsumoto, Hiroki Ishikawa, Daisuke Nishimura, Keisuke Hamasaki, Kazuhiko Nakao, Katsumi Eguchi
Journal: Hepatology (2004)

Pigment epithelium-derived factor (PEDF) is one of the most powerful endogenous antiangiogenic reagents discovered to date. Its antiangiogenic potential in neoplastic disease remains unclear. In this study, we investigated antiangiogenic property of PEDF in hepatocellular carcinoma (HCC), a typical hypervascular tumor. In HCC cell lines, constitutive messenger RNA and protein expression of PEDF varied. Genomic DNA encoding the PEDF gene was the same in the cell lines examined by Southern blotting. In chemically induced hypoxic conditions, secreted PEDF protein was suppressed in contrast to elevation of vascular endothelial growth factor protein. When PEDF was overexpressed by gene transfer, proliferation and migration of endothelial cells were inhibited in conditioned media derived from all HCC cell lines. However, the serum concentration of PEDF, as measured by enzyme-linked immunosorbent assay, was decreased in patients with cirrhosis or HCC complicated by cirrhosis compared to healthy volunteers and patients with chronic hepatitis. According to the endothelial cell proliferation assay, the serum PEDF of patients with HCC had antiangiogenic activity. Moreover, intratumoral injection of a PEDF-expressing plasmid in athymic mouse models caused significant inhibition of preestablished tumor growth. In conclusion, PEDF plays a role in the angiogenic properties of HCC. Reduction of serum PEDF concentration associated with the development of chronic liver diseases may contribute to the progression of HCC. In addition, gene therapy using PEDF may provide an efficient treatment for HCC. (Hepatology 2004;40:252-259.)
A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS
Authors: Jordi Casals, Peter K. Olitsky, Ralph O. Anslow
Journal: The Journal of Experimental Medicine (1951)

A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this virus. Twenty-one of 35 human sera obtained from individuals convalescent from poliomyelitis were positive and 6 of 22 from apparently normal persons having Lansing-neutralizing antibody, while this held true for only 1 of 19 from those having no Lansing-neutralizing antibody. The fact that positive results were found in sera from patients having an infection with poliomyelitis virus of the Brunhilde type and at the same time no Lansing-neutralizing antibody brings up the possibility of the existence of a cross-reaction in complement fixation between the two types.