tbuckley/cabot-search huggingface dataset:
Cyclophosphamide-bortezomib-dexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis
Authors: Joseph R. Mikhael, Steven R. Schuster, Victor H. Jimenez-Zepeda, Nancy Bello, Jacy Spong, Craig B. Reeder, A. Keith Stewart, P. Leif Bergsagel, Rafael Fonseca
Journal: Blood (2012)
Lateral chest radiography or a chicken in every pot.
Authors: B Golberg
Journal: BMJ (1980)

Lateral chest radiography or a chicken in every pot B GOLBERG Recently one of the medical housemen in our hospital had occasion to write in large felt-tip letters across a request form for a radiograph "When I ask for a lateral, I want a lateral!" Being relatively new to the hospital and the NHS (after all a house physician's job lasts only six months), he may not have appreciated what preceded, or antedated, the circumstances that gave him cause for his outburst.These put me in mind of the joke in recent circulation, "Say, what preceded the following 9W."The answer is "Do you spell your name with a V, Herr Wagner"-not an answer that would immediately come to mind unless you had already heard the joke.As it happens I have been concerned with the lateral chest
CEMENT DERMATITIS AND ATMOSPHERIC PARAMETERS IN KUWAIT*
Authors: M. WAJDI KANAN
Journal: British Journal of Dermatology (1972)

Summary.— A series of 191 male patients, 2 Kuwaitis and 189 non-Kuwaiti immigrants from the Middle East, with cement dermatitis, is reported. On the first visit 108 patients had already passed into the chronic stage and 40% showed an irregular nummular pattern. On patch testing, all 191 patients reacted positively to 0·5% potassium dichromate but only 13 of them reacted to 5% cobalt chloride, which incriminated the chromates as the significant allergen in cement dermatitis in Kuwait. Of the 191 patients, only 16 had suffered from transient dermatitis in their countries of origin. Seventy-seven of the remaining 175 patients came in contact with cement for the first time in Kuwait, whereas the other 88 patients had never had dermatitis in their countries of origin, in spite of long contact with cement. Of 112 patients who were followed up for a period longer than 2 years, 84 (75%) were observed to have clinical exacerbation between April and mid-November each year. The curve describing the latter was found to be a direct function of the curve obtained for the temperature monthly means. The rising humidity during September each year overtook the high temperature, which probably provoked excessive perspiration and thus favoured the leaching of chromate ions by the integument.
The President Vetoes Stricter Congressional Oversight of NIH
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1984)

The National Institutes of Health (NIH), vested with more money and higher acclaim by Congress than ever before, enjoys a reputation that is perhaps without equal among federal agencies. Yet, even at the height of its standing in the political arena, this world-renowned institution is buffeted by strong pressures to reconfigure its organizational structure, subject its operations to closer congressional scrutiny, and restrict its use of animals in medical research and its pursuit of fetal research.Only President Reagan's veto of the Health Research Extension Act of 1983, a week before his reelection November 6, thwarted legislation that sought to . . .
PULSATING EXOPHTHALMOS; SUCCESSIVE LIGATION OF BOTH COMMON CAROTID ARTERIES; DEATH.
Authors: HOWARD F. HANSELL
Journal: JAMA (1905)

<h3>Patient.</h3> —S. C., a strong, healthy-looking girl, 22 years of age, applied at the eye dispensary of the Jefferson Medical College Hospital July 30, 1903. She complained of pain in the left eye and left side of the head, and of a constant subjective noise. <h3>History.</h3> —On the evening of July 3 she was struck on the inner angle of the right orbit, between the internal canthus and the nasal bone, by the handle of a heavy butcher knife, thrown from a distance of about 15 feet. Both lids of the right eye were bruised and slightly cut, and the nose bled, but other than these insignificant injuries she suffered no immediate ill effects. On the following day she noticed a noise in the head, which she referred more particularly to the<i>left</i>side. Two weeks later the left eye became prominent. <h3>Examination.</h3> —At the time of the
Informed Demand for “Non-Beneficial” Medical Treatment
Authors: S H Miles
Journal: New England Journal of Medicine (1991)

An 85-year-old woman was taken from a nursing home to Hennepin County Medical Center on January 1, 1990, for emergency treatment of dyspnea from chronic bronchiectasis. The patient, Mrs. Helga Wanglie, required emergency intubation and was placed on a respirator. She occasionally acknowledged discomfort and recognized her family but could not communicate clearly. In May, after attempts to wean her from the respirator failed, she was discharged to a chronic care hospital. One week later, her heart stopped during a weaning attempt; she was resuscitated and taken to another hospital for intensive care. She remained unconscious, and a physician suggested . . .
Abstract 4549: Hemodynamic Mecahnisms Of Endocardial Fibroelastosis (EFE) In The Developing Rat Heart
Authors: Ivan Melnychenko, Nikolay V Vasilyev, Elisabeth Scherr, Ingeborg Friehs, Dimitrios Poutias, Pedro J del Nido
Journal: Circulation (2008)

Background. The mechanisms for development and progression of EFE as well as its causal relationship to hypoplastic heart syndrome are unknown, although subendocardial ischemia in-utero has been in...
THE DURATION AND EXTENT OF INDUCED RESISTANCE TOWARD TUMOR TRANSPLANTATION IN MICE
Authors: William H. Woglom
Journal: The Journal of Experimental Medicine (1912)

The foregoing experiments demonstrate that the immunity induced in mice by preliminary treatment with tumor or certain of the normal tissues reaches its maximum at about the tenth day, after which it gradually diminishes, probably to disappear after the lapse of about eighty days. It is significant that the curves with the three tissues, spontaneous tumor, kidney, and embryo skin, should parallel each other so closely, and the occurrence renders extremely probable the view, previously expressed by Russell and by Woglom after an examination of very young grafts in immune mice and rats respectively, that the resistance elicited in each case is similar. It is evident, however, that there is a difference in the degree to which it is developed.
Left Main Coronary Artery Stenosis
Authors: HOWARD J. ZEFT, JACK C. MANLEY, JOHN H. HUSTON, ALFRED J. TECTOR, JAMES E. AUER, W. DUDLEY JOHNSON
Journal: Circulation (1974)

Fifty-six patients with severe stenosis of the left main coronary artery underwent coronary bypass surgery between January 1970 and December 1971. All patients had angina pectoris. Seventy-five per cent of the patients had an unstable anginal pattern. There were six perioperative deaths for a surgical mortality of 10.7%. Of the 50 patients surviving surgery, 96% are alive from 12 to 36 months postoperatively, 90% have had a significant reduction in anginal symptoms and 76% are asymptomatic. Postoperative catheterization studies, performed one to 28 months after surgery in 31 patients, showed that 83% of 75 bypass grafts were widely patent. In each patient studied there was at least one widely patent graft to the left coronary artery. Six patients had exercise studies using supine bicycle ergometry during pre- and postoperative cardiac catheterization. These studies demonstrated improvement in exercise tolerance and in left ventricular hemodynamics after coronary surgery.
Abstract 5578: Quantitative kinase inhibitor profiling in native cell and tissue extracts
Authors: Matthew P. Patricelli, Tyzoon K. Nomanbhoy, John W. Kozarich, Nathanael S. Gray, Jianming Zhang, Jiangyue Wu
Journal: Cancer Research (2010)

Abstract Protein kinases are currently the subject of intense pharmaceutical industry attention. An array of assays and tools have been developed to study their biological and structural properties, however despite these efforts, many questions remain regarding the nature and functional consequences of kinase regulatory events in vivo. We previously detailed a probe-based method for comprehensively probing the ATP binding sites of native protein kinases directly in cell or tissue lysates. Here we report several advances that dramatically increase the sensitivity, quantitative accuracy, and efficiency of this method. Using these improved methods, we determined the Kd values of ATP, Staurosporine and several clinically relevant kinase inhibitors against more than 200 protein and lipid kinases in two cell lines (HL60 and PC3). While the data supports many general trends and confirmed targets of the inhibitors identified through recombinant kinase assays, several striking differences were found. Detailed investigation of these differences reveal that native kinases can exhibit dramatically different behavior when compared to their recombinant counterparts. Overall these data provide an unprecedented picture of native kinase behavior and have profound implications for the development of kinase inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5578.
Prednisolone withdrawal therapy enhances the effect of human lymphoblastoid interferon in chronic hepatitis B
Authors: Kim Krogsgaard, Patrick Marcellin, Christian Trepo, Pierre Berthelot, José M Sanchez-Tapias, Maggie Bassendine, Albert Tran, Denis Ouzan, Helmer Ring-Larsen, Johan Lindberg, Jaime Enriquez, Jean-Pierre Benhamou, Niels Bindslev
Journal: Journal of Hepatology (1996)
Life-Threatening Intraabdominal Arterial Embolization After Histoacryl Injection for Bleeding Gastric Ulcer
Authors: G. H. Lee, J. H. Kim, K. J. Lee, B M. Yoo, K. B. Hahm, S. W. Cho, Y. S Park, Y. S. Moon
Journal: Endoscopy (2000)

N-butyl-cyanoacrylate (Histoacryl) injection has become the treatment of choice for acutely bleeding esophagogastric varices, and is the only effective option for endoscopic treatment of gastric varices. Recent reports confirm the ability of Histoacryl injection therapy to achieve immediate hemostasis in cases of gastric ulcer bleeding or Dieulafoy ulcer, where conventional endoscopic hemostatic treatment had failed. Although the overall safety record of Histoacryl injection has been relatively good, there have been scattered cases of serious complications. Here, we present two patients showing life-threatening intraabdominal arterial embolization after Histoacryl injection. They had chronic gastric ulcers with active arterial bleeding. In spite of attempts at hemostatic treatment, complete hemostasis was not achieved. We injected Histoacryl, diluted with Lipiodol, into bleeding gastric ulcers, resulting in successful hemostasis. Soon after the procedure, intraabdominal arterial embolization developed in both patients. One patient survived and the other died. Based on these experiences, we would like to warn gastrointestinal endoscopists to be alert to these fatal complications, and we propose that less diluted Histoacryl seems to be preferable in cases of bleeding peptic ulcers.
Tumors of the Endocrine Pancreas
Authors: Stanley R. Friesen
Journal: New England Journal of Medicine (1982)

THE more frequent recognition of endocrine tumors of the pancreas within the past decade can be largely attributed to better characterization of the associated clinical syndromes, coupled with improved methods of diagnosis. The single most important factor facilitating the clinical recognition of new syndromes has been the development of immunoreactive assays for an increasing number of circulating polypeptides elaborated by a variety of islet-cell tumors. The proliferation of newly recognized syndromes calls for a review of the current state of their understanding.Neuroendocrine cells of the pancreatic islets normally release amines and polypeptides, which serve to coordinate the physiologic processes . . .
Sunscreen abuse for intentional sun exposure
Authors: P. Autier
Journal: British Journal of Dermatology (2009)

Skin cancer is caused by exposure to ultraviolet radiation (UV) and the sun is the main source of this radiation. Sunscreens were initially formulated to prevent sunburns; laboratory studies later revealed that in rodents they could reduce UV-induced skin cancer which resembles human squamous cell carcinoma. Three randomized trials in older adults showed the ability of sunscreens to moderately reduce the occurrence of solar keratoses and of squamous cell carcinoma. However, no effect was observed for basal cell carcinoma. There is no animal model for human melanoma and observational studies often found sunscreen use associated with a higher risk of nevus, melanoma and basal cell carcinoma. These higher risks were found when sun exposure appeared to be intentional, that is, with the desire to acquire a tan, a healthy look or simply to spend as long as possible in the sun with as much skin exposed as possible. Three randomized trials showed that sunscreen use by sun sensitive subjects engaging in intentional sun exposure could increase the duration of exposure without decreasing sunburn occurrence. This increased duration could be the reason why melanoma risk is increased when sunscreen is used. Hence, sunscreen abuse may extend sun exposure duration thus allowing sun exposure behaviours that would not be possible otherwise. Advertising for sunscreens and labeling of sunscreen bottles should inform consumers of the carcinogenic hazards associated with sunscreen abuse. It would be good to use a personal UV dosimeter which would give an alert when one's individual sunburn threshold in the absence of sunscreen use is nearing. The combination of sunscreen and a UV dosimeter may be an option for reducing the melanoma risk among sun worshippers.
HYGIENE IN THE RURAL DISTRICTS.
Authors: GEO. W. JENKINS
Journal: JAMA (1891)

mortality from pneumonia and other acute dis¬ eases of the respiratory organs to be more than doubled ; from typhoid fever to be trebled ; and from diarrhoeal diseases to be increased five fold.Etiological Conditions.--In considering the eti¬ ological conditions preceding, accompanying, and following the epidemic of the first quarter of 1890, in the paper I read to this Section at the last an¬ nual meeting, it was shown that during the time of the epidemic, the water supplied to the inhab¬ itants contained an unsafe amount of free and al¬ buminoid ammonia and of microorganisms.It was also shown that during the month preceding the outbreak of the epidemic, the mean atmos¬ pheric temperature was 9°F .above that of the same month of the preceding healthy year, and that of the month during which it reached its climax, the mean temperature was 2.4°F .above -
Genetic link explains greater prevalence of heart failure among black Americans
Authors: S. Gottlieb
Journal: BMJ (2002)

Researchers have linked two common gene variations with a higher risk of congestive heart failure among black Americans than other Americans. The researchers said the findings could lead to a way to spot people who are particularly susceptible to congestive heart failure.

The gene variants may also partly explain why congestive heart failure is twice as common among black Americans as white people ( New England Journal of Medicine 2002;347:1135-42).

Dr Stephen Liggett of the University of Cincinnati, Ohio, and colleagues found that particular variations of two genes that govern two cell …
THE LUNG VOLUME IN HEART DISEASE
Authors: Carl A. L. Binger
Journal: The Journal of Experimental Medicine (1923)

The lung volumes in a group of individuals suffering from chronic cardiac disease have been studied by a method which is applicable to patients suffering from dyspnea. In a number of instances the same patients were investigated during various stages of decompensation and compensation. The values found have been compared with those determined in a group of normal subjects. Lung volumes have been considered from three points of view: (1) relative lung volumes or subdivisions of total lung volume expressed as percentage of total lung volume; (2) the absolute lung volumes of patients with heart disease have been compared with lung volumes calculated for normal individuals having similar surface areas or chest measurements; and (3) in individual cases absolute lung volumes have been measured in various stages of compensation and decompensation. (1) In patients with heart disease it has been observed that the vital capacity forms a portion of the total lung volume relatively smaller than in normal individuals, and that the mid-capacity and residual air form relatively larger portions. When the patient progresses from the compensated to the decompensated state these changes become more pronounced. (2) When the absolute lung volumes determined for patients are compared with volumes of the same sort, as calculated for normal individuals of the same surface areas and chest measurements, the following differences are found. The vital capacities are always smaller in the patients and the volumes of residual air are always larger. There is a tendency for middle capacity and total capacity to be smaller, though, when the patients are in a compensated state, these volumes may approximate normal. (3) When decompensation occurs the absolute lung volumes undergo changes as follows: (a) vital capacity, mid-capacity, and total capacity decrease in volume; and (b) the residual air may either increase or decrease according to the severity of the state of decompensation. The significance of these changes has been discussed and an explanation offered for the occurrence of a residual air of normal volume in patients with heart disease. It results from a combination of two tendencies working in opposite directions: one to increase the residual air-stiffness of the lungs (Lungenstarre); the other to decrease it-distended capillaries (Lungenschwellung), edema, round cell infiltration.
Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations
Authors: Jordi Martorell, Pablo Santomá, Kumaran Kolandaivelu, Vijaya B. Kolachalama, Pedro Melgar-Lesmes, José J. Molins, Lawrence Garcia, Elazer R. Edelman, Mercedes Balcells
Journal: Cardiovascular Research (2014)

Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may help understand the progression of occlusive arterial disease, providing insights into how to mitigate adverse responses in specific settings and individuals. Vascular architectures mimicking coronary and carotid bifurcations were derived from clinical imaging and used to generate conjoint computational meshes for in silico analysis and biocompatible scaffolds for in vitro models. In parallel with three-dimensional flow simulations, geometrically realistic scaffolds were seeded with human smooth muscle cells (SMC) or endothelial cells and exposed to relevant, physiological flows. In vitro surrogates of endothelial health, atherosclerotic progression, and thrombosis were locally quantified and correlated best with an quantified extent of flow recirculation occurring within the bifurcation models. Oxidized low-density lipoprotein uptake, monocyte adhesion, and tissue factor expression locally rose up to three-fold, and phosphorylated endothelial nitric oxide synthase and Krüppel-like factor 2 decreased up to two-fold in recirculation areas. Isolated testing in straight-tube idealized constructs subject to static, oscillatory, and pulsatile conditions, indicative of different recirculant conditions corroborated these flow-mediated dependencies. Flow drives variations in vascular reactivity and vascular beds. Endothelial health was preserved by arterial flow but jeopardized in regions of flow recirculation in a quasi-linear manner. Similarly, SMC exposed to flow were more thrombogenic in large recirculating regions. Health, thrombosis, and atherosclerosis biomarkers correlate with the extent of recirculation in vascular cells lining certain vascular geometries.
Case of Adder-bite with Thrombosis of the Saphenous Vein
Authors: G. C. Arneil, J. C. Maclaurin
Journal: BMJ (1961)

The mean age of patients with gastric carcinoma is much higher than that of those with peptic ulceration.Because of fewer numbers of surviving sibs, the accu- mulation of sibship data is more difficult.Excesses of group A were noted when the propositi were compared with the unaffected sibs and with the population controls.An excess of A was also found in the propositi of the 16 sibships segregating for group A. None of these differences were of statistical significance.All that TABLE V.-Analysis of the Chance of the Propositus Having Group 0 in the Sibships Segregating for Blood Group 0 After Sibs of the Sex Opposite that of the Propositus are Removed No. of Group 0 Group 0 Sibships Observed Expected Variance Gastric ulcer ..
Remarks on Climate and Sea Voyages in the Treatment of Tuberculosis: Read before the International Tuberculosis Congress in Berlin
Authors: H. Weber
Journal: BMJ (1899)

AT the International Medical Congress at Berlin in I890, I had the honour of introducing the discussion on the Climatic and Hygienic Treatment of Pulmonary Tuberculosis.On that occasion I expressed my opinion that climatic treatment by itself was insufficient in most cases; that careful super- vision and guidance of the patient by the doctor was neces- sary, and that, therefore, treatment in special establishments was to be preferred in the majority of cases, whilst for poor patients it was urgently required.In the present Congress you have appointed me to introduce the discussion on climatic treatment.My opinion, gentle- men, is now more decided than at the former Congress, for I hold that climate is really important, but is insufficient unless there be careful medical hygienic and dietetic guidance.Obeying directions, shall endeavour in a short survey to explain climate can take in the treatment of tuberculosis.I will divide my rapid sum- mary under four heads:i. Climates of mountains and high altitudes.2. Inland climates of low elevation, including those of forest, of deserts, and of Egypt.3.Climates of the coast and of small islands; Sea voyages. 4. Short indications for the use of different climates in different of tuberculosis.I. CLIMATES OF MOUNTAINS AND HIGH ALTITUDES.The differences are great between the various localities which are grouped together under this heading.Whilst in the tropics an elevation of I,8ootO 3,000 metres over the sea is necessary, in the latitudes further from the equator (460 to 540) an elevation of 400 to 500 metres is generally sufficient.Whenthe surroundings of a place are much higher than the place itself, the effect of high altitude is in many respects diminished; the effect is increased when the surroundings are lower.You know, gentlemen, that in former years the prevailing opinion was that consumption was more likely to be cured in warm health resorts than in cold ones, and you know also how scanty were the grounds for this opinion.You are aware that in Lima, the capital of Peru, about I2 degrees south of the equator, consumption is especially frequent, and runs a rapid and fatal course; but that patients, if they go early enough into the neighbouring Peruvian Andes, at an elevationof 2,500 to 3,000 metres above sea level, mostly get bet- ter.For the recognition of this fact we are chiefly indebted to the late Dr. Archibald Smith, who for thirty years exercised the medical profession, partly in Lima itself, and partly in the silver mines of Cerro dePasco, nearly 4,000 metres above the sea.The custom of sending consumptives from the hot