Serum Angiotensin-Converting Enzyme and Lysozyme in Granulomatous Diseases of Unknown Cause
Authors: Paul Katz, Anthony S. Fauci, Henry Yeager, Bernard M. Reen
Journal: Annals of Internal Medicine (1981)

Brief Reports1 March 1981Serum Angiotensin-Converting Enzyme and Lysozyme in Granulomatous Diseases of Unknown CausePAUL KATZ, M.D., ANTHONY S. FAUCI, M.D., HENRY YEAGER Jr., M.D., BERNARD M. REEN, M.D.PAUL KATZ, M.D., ANTHONY S. FAUCI, M.D., HENRY YEAGER Jr., M.D., BERNARD M. REEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-359 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOver the past several years, attempts to develop specific serologic tests for diagnosing sarcoidosis have been the focus of intense investigation. That serum levels of angiotensin-converting enzyme (1) and lysozyme (2) are elevated in this disorder has been established, although the diagnostic value of these tests has been recently questioned (3, 4). The present study was undertaken to ascertain the levels of serum angiotensin-converting enzyme and lysozyme in noninfectious granulomatous disorders of unknown cause other than sarcoidosis.Serum samples from eight patients with granulomatous hepatitis, nine with Wegener's granulomatosis, three with lymphomatoid granulomatosis, and four with midline granuloma were stored...References1. FANBURGSCHOENBERGERBACHUSSNIDER BMBG. Elevated serum angiotensin I converting enzyme in sarcoidosis. Am Rev Respir Dis. 1976;114:525-8. MedlineGoogle Scholar2. SILVERSTEINFRIEDLANDACKERMAN EJT. Elevation of granulomatous lymph-node and serum lysozyme in sarcoidosis and correlation with angiotensin-converting enzyme. Am J Clin Pathol. 1977;68:219-24. CrossrefMedlineGoogle Scholar3. SHULTZMILLERBEDROSSIAN TWC. Clinical application of measurement of angiotensin-converting enzyme level. JAMA. 1979;242:439-41. CrossrefMedlineGoogle Scholar4. PERILLIEKHANFINCH PKS. Serum lysozyme in pulmonary tuberculosis. Am J Med Sci. 1973;265:297-302. CrossrefMedlineGoogle Scholar5. SIMONWOLFF HS. Granulomatous hepatitis and prolonged fever of unknown origin: a study of 13 patients. Medicine (Baltimore). 1973;52:1-21. CrossrefMedlineGoogle Scholar6. FAUCIHAYNESKATZ ABP. The spectrum of vasculitis. Clinical, pathologic, immunologic, and therapeutic considerations. Ann Intern Med. 1978;89:660-76. LinkGoogle Scholar7. FAUCI A. Midline granuloma. In: BEESON PB, MCDERMOTT W, WYNGAARDEN JB, eds. Cecil Textbook of Medicine. 15th ed. Philadelphia: W. B. Saunders; 1979:220-1. Google Scholar8. CUSHMANCHEUNG DH. Spectrophotometry assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol. 1971;20:1637-48. CrossrefMedlineGoogle Scholar9. LITWACK G. Photometric determination of lysozyme activity. Proc Soc Exp Biol Med. 1955;89:401-3. CrossrefMedlineGoogle Scholar10. ISRAELGOLDSTEIN HR. Hepatic granulomatosis and sarcoidosis. Ann Intern Med. 1973;79:669-78. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL KATZ, M.D.; ANTHONY S. FAUCI, M.D.; HENRY YEAGERJr., M.D.; BERNARD M. REEN, M.D.Affiliations: National Institute of Allergy and Infectious Diseases Bethesda, Maryland Georgetown University School of Medicine Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byANCA and associated diseases: immunodiagnostic and pathogenetic aspectsScreening of serum samples from Wegener's granulomatosis patients using antibody microarraysThe Usefulness of Angiotensin Converting Enzyme in the Differential Diagnosis of Crohn's Disease and Intestinal TuberculosisGRANULOMATOUS VASCULITIS, GIANT CELL ARTERITIS, AND SARCOIDOSISSarcoidosis Resulting in Duodenal Obstruction in an AdolescentIdiopathic Granulomatous Orbital InflammationCase 35-1996Case 31-1995The Role of Platelets in Essential HypertensionLysosomal Proteins as Autoantigens of Clinical RelevanceCalcium and vitamin D metabolism in granulomatous diseasesClinical CorrelationsSubretinal neovascularisation and snow banking in a case of sarcoidosis: case report.Angiotensin I converting enzyme activity in hypertension. Relationship to blood pressure, renin-sodium profiles, and antihypertensive therapySerum angiotensin-converting enzyme and delayed hypersensitivity in pulmonary tuberculosisElevated Serum Angiotensin-Converting Enzyme (SACE) Activity in Acute Pulmonary HistoplasmosisUnusual clinical and histopathological findings in ocular sarcoidosis.Elevation of Serum Angiotensin-Converting Enzyme Level 1 March 1981Volume 94, Issue 3Page: 359-360KeywordsAngiotensin converting enzymeFellowshipsGranulomasHepatitisLysozymeResearch grantsSarcoidosisWegener granulomatosis ePublished: 1 December 2008 Issue Published: 1 March 1981 PDF downloadLoading ...