tbuckley/cabot-search huggingface dataset:
Withdrawal of co-proxamol: … and its withdrawal is illogical
Authors: Matthew L Grove
Journal: BMJ (2005)

Junior doctors' shifts and sleep deprivation New on-call rotas do not workEditor-Clearly the editorial by Murray et al on junior doctors' shifts has struck a chord with many, as on-call rotas are something close to many doctors hearts. 1 2 To most it seems the grass is not greener on the other side.Having worked most rotas, be it a traditional one in four, with full weekends, to partial, hybrid, and full shift patterns, I am in a reasonable position to comment on what I think makes a liveable on-call rota.I was under the impression that the European Working Time Directive was set out to improve the health and safety of workers, make working conditions better, but also make life away from work better because doctors would be less tired.The directive scores a "no" against all of these.I find myself more tired at work and at home, less enthusiastic, and less motivated by what is becoming a regular chore.Instead of being on call once a week, I find myself doing an on-call shift two or three times a week (on average), being late home more often than not because fewer juniors are around, and spending less time with my young children.The "old" rota system of a 24 hour oncall, with at least six on a rota, made on-call shifts less frequent, more tolerable, and even enjoyable.It also left plenty of time for training, and so long as there were six or more on rota, it made the annual leave far more flexible and workable.Anaesthetists rarely complained, certainly compared with other specialties' rotas, and everyone knew that however busy, you were always going to go home to a full day off in the morning.Why not listen to those doing the rota, and affected family members, and respect within reason what the workers want to work.
Survival Patterns With In-Hospital Cardiac Arrest
Authors: Roberto Manfredini
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Follow-up Of Wheezing In Preschool Children From The Southern Region Of Sã Paulo, Brazil: International Study Of Wheezing In Infants - Phase 2
Authors: A.C.C. Dela Bianca, G.F. Wandalsen, J. Mallol, D. Solé
Journal: Journal of Allergy and Clinical Immunology (2011)

RATIONALE: The prevalence of wheezing in infants in São Paulo, Brazil, is high, as previously identified by the International Study of Wheezing in Infants (EISL) - Phase 1 (Latin America and Europe). The persistence of wheezing and its related features in this population are unknown. METHOD: Parents of infants who participated in the EISL-Phase 1 in the city of São Paulo, answered a telephone questionnaire after 30.0±6.0 months (mean ± standard deviation) of the first interview. Nearly half of the sample had had wheezing in the first year of life. RESULTS: Parents from 78 (45.9%) children with wheezing and from 92 children without wheezing in the first year of life were interviewed. The average age was 43.0±5.0 months Among the 61 children with current wheezing, 40 (65.6%) had wheezed at the first year of life (persistent wheezing), but only 5 (13.9%) of these children were diagnosed as asthmatics. Children with wheezing in the past 12 months had more respiratory infections, used more antibiotics, had more allergic rhinitis and consumed more industrialized food compared to those with wheezing only in the first year of life. Exposure to cigarette smoke at home was more frequent in this last group. CONCLUSION: Wheezing that started in the first year of life remains frequent among preschool children from São Paulo. There is a frequent use of antibiotics during exacerbations and association with respiratory infections, but the diagnosis of asthma and its specific treatment are still rare.
Reproducibility of new tissue doppler parameters, tissue tracking and strain, in normals and in patients with acute coronary syndrome
Authors: Xiao-Fang Xu, Marcelo Cameiro, None Jing Ping Sun, Lucia Coleman, Jill Odabashian, Zoran Popovic, Allan L. Klein, Neil Greenberg, James D. Thomas
Journal: Journal of the American College of Cardiology (2002)
Good death for all remains distant goal
Authors: R. J. Clearkin
Journal: BMJ (2010)

Ellershaw and colleagues again defend their Liverpool care pathway.1 The pathway has obvious appeal, but it has proved controversial, and reports of misuse remain disturbingly frequent.2

Despite decades of research in the care of patients with cancer, the accurate prediction of dying—the last 48 hours of life—remains difficult.3 Accuracy is …
New-Onset Saquinavir-Induced Diabetes
Authors: Marieke A.D. van Zoelen, A.I.M. Hoepelman, H.W. de Valk
Journal: Diabetes Care (2013)

Saquinavir is an antiviral agent FDA- approved for the treatment of HIV. It inhibits HIV protease, a crucial enzyme for the HIV life cycle that cleaves viral polypeptides into essential proteins. When used in combination with nucleoside analog reverse-transcriptase inhibitors, protease inhibitors are highly effective in reducing HIV viral loads (1,2). In general, saquinavir is safe and well tolerated. Long-term exposure to protease inhibitors is associated with moderate hyperglycemia and insulin resistance in a minority of patients (3). We here report saquinavir as a causing agent of acutely developed extreme hyperglycemia in an HIV patient.

A 35-year-old HIV-infected male originating from Ghana presented with a hyperosmolar, hyperglycemic syndrome (glucose 48 mmol/L). He had been diagnosed with HIV-1 infection 2 years previously, with tenofovir, …
1154-95 Chest compression device improves blood flow in cerebrum and myocardium achieving neurologically intact survival in a porcine model of prolonged cardiac arrest
Authors: Fumiaki Ikeno, Jennifer Lyons, Hideaki Kaneda, Yoichiro Hongo, Sascha Emami, Christine Nolasco, Mehrdad Rezaee
Journal: Journal of the American College of Cardiology (2004)
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis
Authors: Levi B Watkin, Birthe Jessen, Wojciech Wiszniewski, Timothy J Vece, Max Jan, Youbao Sha, Maike Thamsen, Regie L P Santos-Cortez, Kwanghyuk Lee, Tomasz Gambin, Lisa R Forbes, Christopher S Law, Asbjørg Stray-Pedersen, Mickie H Cheng, Emily M Mace, Mark S Anderson, Dongfang Liu, Ling Fung Tang, Sarah K Nicholas, Karen Nahmod, George Makedonas, Debra L Canter, Pui-Yan Kwok, John Hicks, Kirk D Jones, Samantha Penney, Shalini N Jhangiani, Michael D Rosenblum, Sharon D Dell, Michael R Waterfield, Feroz R Papa, Donna M Muzny, Noah Zaitlen, Suzanne M Leal, Claudia Gonzaga-Jauregui, Eric Boerwinkle, N Tony Eissa, Richard A Gibbs, James R Lupski, Jordan S Orange, Anthony K Shum
Journal: Nature Genetics (2015)
Reliability and accuracy of dermatologists’ clinic-based and digital image consultations
Authors: John D. Whited, Russell P. Hall, David L. Simel, Marjorie E. Foy, Karen M. Stechuchak, Rhett J. Drugge, James M. Grichnik, Sarah A. Myers, Ronnie D. Horner
Journal: Journal of the American Academy of Dermatology (1999)
Plasma D-Dimer Levels and Diagnosis of Pulmonary Embolism
Authors: John A. Heit, William L. Nichols
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Goldhaber and colleagues<sup>1</sup>report a 93.3% sensitivity and 91.4% negative predictive value for a fibrin D-dimer value less than 500 ng/mL (Asserachrom D-Di enzyme immunoassay kit, Diagnostica Stago, Asniéres-sur-Seine, France) for acute pulmonary embolism using pulmonary angiography as the diagnostic reference standard. The authors report "no significant relationship between heparin use and D-dimer levels (<i>P</i>=.78)," but do not report the duration of heparin therapy or duration of symptoms prior to D-dimer measurement. Using the same assay, Bounameaux et al<sup>2</sup>found D-dimer levels to be significantly lower on days 3 and 7 compared with the day of presentation (day 1). Speiser et al<sup>3</sup>reported that elevated levels of D-dimer decrease within 24 hours in patients with acute deep vein thrombosis who are treated with heparin. Therefore, the D-dimer sensitivity for acute pulmonary embolism may be appreciably reduced in patients who have been symptomatic
Moving Forward in Human Cancer Risk Assessment
Authors: Richard S. Paules, Jiri Aubrecht, Raffaella Corvi, Bernward Garthoff, Jos C. Kleinjans
Journal: Environmental Health Perspectives (2010)

The current safety paradigm for assessing carcinogenic properties of drugs, cosmetics, industrial chemicals, and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year rodent bioassays. This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks.We provide a response to a growing appeal for a paradigm change in human cancer risk assessment.To facilitate development of a road map for this needed paradigm change in carcinogenicity testing, a workshop titled "Genomics in Cancer Risk Assessment" brought together toxicologists from academia and industry and government regulators and risk assessors from the United States and the European Union. Participants discussed the state-of-the-art in developing alternative testing strategies for carcinogenicity, with emphasis on potential contributions from omics technologies.The goal of human risk assessment is to decide whether a given exposure to an agent is acceptable to human health and to provide risk management measures based on evaluating and predicting the effects of exposures on human health. Although exciting progress is being made using genomics approaches, a new paradigm that uses these methods and human material when possible would provide mechanistic insights that may inform new predictive approaches (e.g., in vitro assays) and facilitate the development of genomics-derived biomarkers. Regulators appear to be willing to accept such approaches where use is clearly defined, evidence is strong, and approaches are qualified for regulatory use.
Monument to Prof. Gross.
Authors: T. J. Happel
Journal: JAMA (1892)

<h3>To the Editor of the Journal of the American Medical Association:</h3> In looking overThe Journalof May 7, page 598,I note that Dr. Lester, of David City, Neb., calls attention to a "delightful odor not unlike that of the tube-rose" which he observes after taking a dose of acetanilid. You state that it is "undoubtedly an idiosyncracy or a phenomenon having a limited range." I can confirm in my own case Dr. Lester's statements, having frequently noted the odor, and having called the attention of others to the fact, and have had them to confirm my discovery. I have, furthermore, frequently stated to other practitioners that I knew that antikamnia contained acetanilid because this peculiar odor developed after I had taken a dose. None of the other phenol derivatives showed this odor. Trenton, Tenn., May 7, 1892.
Abstract 4573: Discovery of candidate biomarkers for colorectal cancer using mass spectrometry-based proteomic analysis of cell line conditioned media
Authors: George S. Karagiannis, Eleftherios P. Diamandis
Journal: Cancer Research (2010)

Abstract Colorectal cancer (CRC) represents the third leading cause of cancer-related deaths with approximately 655,000 deaths annually, worldwide. Specific biomarkers for early detection of CRC are needed, mainly because the currently applied serum biomarkers (CEA, CA 19.9) lack adequate sensitivity and specificity for screening purposes, while colonoscopy is invasive, with considerable cost, risks and inconvenience. In the present study, we utilized a mass spectrometry-based platform to analyze the proteome of the conditioned media from 12 CRC cell lines with diverse genetic profiles, to capture the disease heterogeneity. Proteins were trypsin-digested and fractionated by strong cation-exchange and reverse-phase liquid chromatography prior to mass spectrometric analysis with an LTQ Orbitrap instrument. The samples were run in triplicate and results were searched against the IPI human forward and reverse database, using MASCOT and X!Tandem search engines. We were able to identify approximately 2,000 unique proteins for each cell line, with reproducibility ranging from 71 to 82% among the triplicates. The efficiency of this approach was signified by the large number of known biomarkers, such as CEA, successfully identified in our list of candidates, as well as by the identification of internal control proteins, such as kallikreins 6, 7, 10, and 11, which were also quantified by ELISA in cancer cell supernatants. The acquired protein datasets were further subjected to bioinformatic analysis using Gene Ontology. The proteins were assigned a subcellular localization and 35-40% were classified as extracellular or plasma membrane proteins. Further mining of this vast database by using bioinformatics tools and experimental approaches (such as multiple reaction monitoring and ELISA) could lead to shortlists of proteins that may have utility as circulating CRC biomarkers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4573.
Differences in long‐term survival among liver transplant recipients and the general population: A population‐based nordic study
Authors: Fredrik Åberg, Mika Gissler, Tom H. Karlsen, Bo‐Göran Ericzon, Aksel Foss, Allan Rasmussen, William Bennet, Michael Olausson, Pål‐Dag Line, Arno Nordin, Annika Bergquist, Kirsten Muri Boberg, Maria Castedal, Christian Ross Pedersen, Helena Isoniemi
Journal: Hepatology (2014)

Dramatic improvement in first-year outcomes post-liver transplantation (LT) has shifted attention to long-term survival, where efforts are now needed to achieve improvement. Understanding the causes of premature death is a prerequisite for improving long-term outcome. Overall and cause-specific mortality of 3,299 Nordic LT patients (1985-2009) having survived 1 year post-LT were divided by expected rates in the general population, adjusted for age, sex, calendar date, and country to yield standardized mortality ratios (SMRs). Data came from the Nordic Liver-Transplant Registry and WHO mortality-indicator database. Stagnant patient survival rates >1 year post-LT were 21% lower at 10 years than expected survival for the general population. Overall SMR for death before age 75 (premature mortality) was 5.8 (95% confidence interval [CI] 5.4-6.3), with improvement from 1985-1999 to 2000-2010 in hepatitis C (HCV) (SMR change 23.1-9.2), hepatocellular carcinoma (HCC) (SMR 38.4-18.8), and primary sclerosing cholangitis (SMR 11.0-4.2), and deterioration in alcoholic liver disease (8.3-24.0) and acute liver failure (ALF) (5.9-7.6). SMRs for cancer and liver disease (recurrent or transplant-unrelated disease) were elevated in all indications except primary biliary cirrhosis (PBC). Absolute mortality rates underestimated the elevated premature mortality from infections (SMR 22-693) and kidney disease (SMR 13-45) across all indications, and from suicide in HCV and ALF. SMR for cardiovascular disease was significant only in PBC and alcoholic liver disease, owing to high mortality in the general population. Transplant-specific events caused 16% of deaths.standardized premature mortality provided an improved picture of long-term post-LT outcome, showing improvement over time in some indications, not revealed by overall absolute mortality rates. Causes with high premature mortality (infections, cancer, kidney and liver disease, and suicide) merit increased attention in clinical patient follow-up and future research.
Pain Work-up
Authors: JEREMY NOBEL
Journal: Annals of Internal Medicine (1982)

Ad Libitum1 April 1982Pain Work-upJEREMY NOBEL, M.D.JEREMY NOBEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-523_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTell me about the pain.Is it sharp or dull?What brings it on?What makes it go away?Does it feel better after eating?Can you tolerate greasy foods?Does it get relieved when you lie down?Is it worse in the morning or evening?Put your finger on the spot that hurts most.Does it come and go or is the pain constant?Does it radiate through to your back or shoulder?Does it crumple you in half when the pain comes?Do you feel like a small animal is nibbling inside you?Do you wake in the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1982Volume 96, Issue 4Page: 523-523KeywordsEatingFoodShoulders ePublished: 1 December 2008 Issue Published: 1 April 1982 PDF downloadLoading ...
Hearing loss and personal music players
Authors: P. M. Rabinowitz
Journal: BMJ (2010)

Reducing exposure is prudent

Hearing loss affects 16% of US adults aged 20-69 and its prevalence increases with age.1 Although often subtle, the deficit impairs perception of speech and warning signals and may increase the risk of depression, accidents, and social isolation.2

The leading preventable cause of acquired sensorineural hearing loss is exposure to excessive levels of noise, which leads to irreversible loss of cochlear hair cells. Traditionally, noise induced hearing loss was a disease of adults who worked in noisy occupations or used firearms. However, concern is growing that children and young adults are developing noise induced hearing loss as a result of “environmental” overexposure to amplified music,3 especially through the use of personal music devices such as MP3 players.

As with mobile phones, the use of personal music players has grown faster than our ability to assess their potential health consequences. The reported use of these devices is high in young people—more than 90% in …
Increasing Prevalence of Type 2 Diabetes in Chinese Adults in Shanghai
Authors: Rui Li, Wei Lu, Qing Wu Jiang, Yan Yun Li, Gen Ming Zhao, Liang Shi, Qun Di Yang, Ye Ruan, Junyi Jiang, Sheng Nian Zhang, Wang Hong Xu, Wei Jian Zhong
Journal: Diabetes Care (2012)

Our objective was to determine the secular trend in prevalence of type 2 diabetes in Shanghai, China.Two consecutive population-based surveys for type 2 diabetes were conducted in randomly selected adults aged 35-74 years in Shanghai in 2002-2003 (n = 12,329) and in 2009 (n = 7,423). Diagnosed type 2 diabetes was determined based on self-report, whereas those undiagnosed were identified by measured fasting and postload glucose according to 2009 American Diabetes Association criteria.Age-standardized prevalence of diagnosed and undiagnosed type 2 diabetes increased from 5.1 and 4.6% in 2002-2003 to 7.4 and 5.2% in 2009. The prevalence of type 2 diabetes increased with age and was higher among men and in urban residents in both surveys (P < 0.001). Between the two surveys, the increase in the prevalence was more evident in the rural population (P < 0.001) and appeared more rapid in younger birth cohorts (P < 0.05).Our results suggest that Shanghai has experienced an increasing burden of type 2 diabetes.
AIDS virus–specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape
Authors: Nicholas J. Maness, Laura E. Valentine, Gemma E. May, Jason Reed, Shari M. Piaskowski, Taeko Soma, Jessica Furlott, Eva G. Rakasz, Thomas C. Friedrich, David A. Price, Emma Gostick, Austin L. Hughes, John Sidney, Alessandro Sette, Nancy A. Wilson, David I. Watkins
Journal: The Journal of Experimental Medicine (2007)

Cryptic major histocompatibility complex class I epitopes have been detected in several pathogens, but their importance in the immune response to AIDS viruses remains unknown. Here, we show that Mamu-B*17+ simian immunodeficiency virus (SIV)mac239-infected rhesus macaques that spontaneously controlled viral replication consistently made strong CD8+ T lymphocyte (CD8-TL) responses against a cryptic epitope, RHLAFKCLW (cRW9). Importantly, cRW9-specific CD8-TL selected for viral variation in vivo and effectively suppressed SIV replication in vitro, suggesting that they might play a key role in the SIV-specific response. The discovery of an immunodominant CD8-TL response in elite controller macaques against a cryptic epitope suggests that the AIDS virus–specific cellular immune response is likely far more complex than is generally assumed.
Growth inhibition of fibroblasts from nasal polyps and normal skin by lysine acetylsalicylate
Authors: N. Bruzzese, G. Sica, F. Iacopino, G. Paludetti, D. Schiavino, E. Nucera, E. Scarano, G. Patriarca
Journal: Allergy (1998)

Some authors have shown that lysine acetylsalicylate (LAS) may help prevent nasal polyp relapses. As some anti-inflammatory drugs have been found to regulate cell growth, we investigated the antiproliferative effect of LAS on fibroblasts derived from nasal polyps. Moreover, we studied the effect of LAS on the growth of fibroblasts derived from normal skin to determine whether the response was similar to that obtained in the above-mentioned cells. Fibroblasts were obtained from tissue samples of nasal polyps from two aspirin-tolerant and two aspirin-intolerant patients, and from the normal skin of a healthy donor. The cells were treated with LAS (20-2000 microg/ml of culture medium). Cell growth and viability were evaluated after 3 and 6 days of culture. LAS had a growth-inhibitory effect on cells independently of their derivation. A reduction in cell growth was seen at the concentrations of LAS tested, which correspond to those used in the local treatment of nasal polyposis.