tbuckley/cabot-search huggingface dataset:
CORRECTION OF AN ABSTRACT
Authors: SHELDON BAUM
Journal: Annals of Internal Medicine (1966)

Letters and Comments1 August 1966CORRECTION OF AN ABSTRACTSHELDON BAUM, M.D., LAWRENCE SILVER, M.D., F.A.C.P.SHELDON BAUM, M.D.Search for more papers by this author, LAWRENCE SILVER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-382 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: After submission of the abstract, "The Detection of Hepatic Metastases by Radioisotope Scanning," which appeared in the May, 1966 ANNALS, an error was detected that necessitated a minor alteration in the paper. It was found that in one patient with proved liver metastases, the scan was interpreted as being negative rather than showing metastases as is indicated in the abstract. The data have been corrected in accordance with the change in category of this single patient. This correction was incorporated at the time of presentation of the paper.Radioisotope scans were interpreted as showing liver metastases in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SHELDON BAUM, M.D.; LAWRENCE SILVER, M.D., F.A.C.P.Affiliations: Department of Nuclear Medicine Long Island Jewish Hospital Queens Hospital Center Affiliation Jamaica, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1966Volume 65, Issue 2Page: 382-382KeywordsLiverRadionuclide imaging ePublished: 1 December 2008 Issue Published: 1 August 1966 PDF downloadLoading ...
Book: Brave New Brain: Conquering Mental Illness in the Era of the Genome
Authors: S. A Spence
Journal: BMJ (2001)

Nancy C Andreasen Oxford University Press, £19.99, pp 368 ISBN 0 19 514509 7 Rating: ![Graphic][1]</img> ![Graphic][2]</img> ![Graphic][3]</img> In 1984 Professor Andreasen published a book called The Broken Brain: The Biological Revolution in Psychiatry . This influenced many latter day psychiatrists (myself included). Now Andreasen has produced a work in which she attempts to assay the field of contemporary psychiatric research, as psychiatry enters the 21st century, sandwiched between two major technological developments: the sequencing of the human genome and the use of neuroimaging to examine the structure and function of the living brain. Is … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Prevalence of respiratory conditions among schoolchildren exposed to different levels of air pollutants in the Haifa Bay area, Israel.
Authors: A I Goren, S Hellman, S Brenner, N Egoz, S Rishpon
Journal: Environmental Health Perspectives (1990)

During spring 1984, 2334 second and 2000 fifth-grade schoolchildren living in three Haifa Bay areas on the eastern Mediterranean coast with different levels of air pollution were studied. The parents of these children filled out American Thoracic Society and National Heart and Lung Institute health questionnaires, and the children performed the following pulmonary function tests (PFT); FVC, FEV1, FEV1/FEV, PEF, FEF50, and FEF75. A trend of higher prevalence of most reported respiratory symptoms was found for schoolchildren growing up in the medium and high pollution areas as compared with the low pollution area. Part of the reported respiratory diseases were significantly more common among children from the high pollution area. Models fitted for the respiratory conditions that differed significantly among the three areas of residence also included background variables that could be responsible for these differences. Relative risk values, which were calculated from the logistic models, were in the range of 1.38 for sputum with cold and 1.81 for sputum without cold for children from the high pollution area as compared with 1.00 for children from the low pollution area. All the measured values of PFT were within the normal range. There was no consistent trend of reduced pulmonary function that characterized any residential area.
Prevention of Duodenal Ulcer Recurrence
Authors: WILLIAMSON B. STRUM
Journal: Annals of Internal Medicine (1986)

Recurrent duodenal ulcers, treated with Cimetidine, 400 mg, or ranitidine, 150 mg, once nightly, or with sucralfate, 1 g twice daily, can be prevented in approximately 75% of patients for up to 1 year. Because these drugs are generally of equal efficacy, the choice is based on the patient's previous drug experience and tolerance, potential side effects, risk of drug interaction, frequency of administration, and cost. These medications do not alter the natural history of duodenal ulcer disease, and therapy may need to continue for longer than 1 year if there are no long-term side effects. Extra efforts should be made to help cigarette smokers discontinue smoking. Patients who have recurrent duodenal ulcers during maintenance therapy can be retreated with full-dose therapy. If optimal drug therapy is unsuccessful in preventing frequent recurrences or complications, surgical treatment is indicated.
Ulceration of the lip associated with a 'calibre-persistent artery'
Authors: R.J. MARSHALL, B.J. LEPPARD
Journal: British Journal of Dermatology (1985)

A case of ulceration of the lower lip, associated with a 'calibre-persistent artery', is presented. The lesion was diagnosed clinically as squamous cell carcinoma and excised accordingly. 'Calibre-persistent artery' is not a widely known entity, has not been described previously in the dermatological literature and should be sought in any lip ulcer of obscure aetiology.
Choice in matters of life and death
Authors: F. Godlee
Journal: BMJ (2014)

Calls for more money for the NHS are gaining urgency. In a stark report in May the think tank the King’s Fund warned of a financial crisis this year unless the funding gap were filled (doi:10.1136/bmj.g3048). Now three prominent MPs have added their voices, calling for an urgent injection of £15bn (€19bn; $26bn) over the next five years. The new chair of parliament’s Health Committee, Sarah Wollaston, has said, “If there is not an increase, it is hard to see how we could maintain current levels of service given the rising demand” (doi:10.1136/bmj.g4364).

Fears that the NHS won’t cope were abated in some quarters by a report in June by the US Commonwealth …
Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients
Authors: Noel F. C. C. de Miranda, Konstantinos Georgiou, Longyun Chen, Chenglin Wu, Zhibo Gao, Apostolos Zaravinos, Susana Lisboa, Gunilla Enblad, Manuel R. Teixeira, Yixin Zeng, Roujun Peng, Qiang Pan-Hammarström
Journal: Blood (2014)
Plasma jet takes off.
Authors: L Frazer
Journal: Environmental Health Perspectives (1999)

Thanks to a series of joint research projects by Los Alamos National Laboratory, Beta Squared of Allen, Texas, and the University of California at Los Angeles, there is now a more environmentally sound method for cleaning semiconductor chips that may also be effective in cleaning up chemical, bacterial, and nuclear contaminants. The Atmospheric Pressure Plasma Jet uses a type of ionized gas called plasma to clean up contaminants by binding to them and lifting them away. In contrast to the corrosive acids and chemical solvents traditionally used to clean semiconductor chips, the jet oxidizes contaminants, producing only benign gaseous by-products such as oxygen and carbon dioxide. The new technology is also easy to transport, cleans thoroughly and quickly, and presents no hazards to its operators.
Rheumatoid factor, vascular damage, and hypertension.
Authors: A Ebringer
Journal: BMJ (1970)

speculating on the pathogenesis in death from respiratory syncytial virus (R.S.V.) infection prompts us to report the following case of infant death with R.S.V. infection.A male child, 4 weeks of age, died three weeks after discharge from a mater- nity hospital.During the three weeks at home he suffered from "chest infections" for which he received two five-day courses of Ampiclox (ampicillin and cloxacillin).Two days before admission to hospital the baby stopped feeding and had a "cold."On examination in hospital he was under- nourished and dehydrated, with a bulging anterior fontanelle.He died less than 24 hours after admission.Postmortem examination showed infarction of the right cerebral hemisphere, the distribution of which suggested extension of a birth injury.There was no evidence of pneumonia or bronchiolitis, but the finding of mucopus in
Pulmonary Hypertension — Beyond Vasodilator Therapy
Authors: Alfred P. Fishman
Journal: New England Journal of Medicine (1998)

In 1891, Romberg described the autopsy findings in a patient with unexplained pulmonary hypertension.1 For decades thereafter, case reports and small series added to this original report. About a half-century later, after the introduction of right-heart catheterization in humans, Dresdale showed that the intravenous administration of tolazoline, a systemic vasodilator, could decrease pulmonary vascular resistance in patients with unexplained pulmonary hypertension, which he designated “primary” pulmonary hypertension. Others subsequently tested a variety of systemic vasodilators for their hemodynamic effects and embarked on short trials of therapy.1 However, until the 1990s, the only study in which drugs improved survival was a . . .
Functional Bowel Disorders Without Tears
Authors: HARVEY J. DWORKEN
Journal: Annals of Internal Medicine (1980)

Editorial Notes1 November 1980Functional Bowel Disorders Without TearsHARVEY J. DWORKEN, M.D.HARVEY J. DWORKEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-5-776 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur epidemiologic knowledge of functional bowel disorders has recently been expanded by the interesting finding that gastrointestinal symptoms occur with considerable frequency among healthy, largely uncomplaining British adults of both sexes and a wide span of ages (1). Structured interviews of 301 adults, including medical technicians, nurses, hospital clerks, persons attending a clinic screening for coronary artery disease, and residents of housing projects for the elderly, showed that nearly one third of the subjects had experienced gastrointestinal symptoms in the preceding year. Typical symptoms of the irritable bowel syndrome had been noted by 13.6% of the subjects, painless constipation by...References1. THOMPSON W and HEATON K. Functional bowel disorders in apparently healthy people. Gastroenterology 1980;79:283-8. CrossrefMedlineGoogle Scholar2. MANNING A, THOMPSON W, HEATON K, and MORRIS A. Towards positive diagnosis of the irritable bowel. Br Med J 1978;2:653-4. CrossrefMedlineGoogle Scholar3. ESLER M and GOULSTON K. Levels of anxiety in colonic disorders. N Engl J Med. 1973;288:13-6. CrossrefMedlineGoogle Scholar4. EARLHAM R. A computerized questionnaire analysis of duodenal ulcer symptoms. Gastroenterology 1976;71:314-7. CrossrefMedlineGoogle Scholar5. DE LA VEGA J. Diverticular disease of the colon: Part I. Medical aspects. In: BOCKUS HL, ed. Gastroenterology. Vol. ii, 3rd ed. Philadelphia: W. B. Saunders Co.; 1976:981. Google Scholar6. ALMY T and HOWELL D. Diverticular disease of the colon. N Engl J Med. 1980;302:324-31. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARVEY J. DWORKEN, M.D.Affiliations: University Hospitals Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1980Volume 93, Issue 5Page: 776-777KeywordsConstipationConstipation-predominant irritable bowel syndromeElderlyEpidemiologyHospitalsIrritable bowel syndromeStable coronary artery diseaseTechnicians ePublished: 1 December 2008 Issue Published: 1 November 1980 PDF downloadLoading ...
Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
Authors: David A Tuveson, Alice T Shaw, Nicholas A Willis, Daniel P Silver, Erica L Jackson, Sandy Chang, Kim L Mercer, Rebecca Grochow, Hanno Hock, Denise Crowley, Sunil R Hingorani, Tal Zaks, Catrina King, Michael A Jacobetz, Lifu Wang, Roderick T Bronson, Stuart H Orkin, Ronald A DePinho, Tyler Jacks
Journal: Cancer Cell (2004)
CHARACTERISTICS AND OUTCOMES OF MEDICALLY MANAGED PATIENTS WITH NON-ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROMES: INSIGHTS FROM THE MULTINATIONAL EPICOR ASIA STUDY
Authors: Chee Tang Chin, Stephen W-L. Lee, Jitendra P.S. Sawhney, Tiong K. Ong, Hyo-Soo Kim, Angeles Alonso Garcia, Héctor Bueno, Rungroj Krittayaphong, Stuart J. Pocock, Vo T. Nhan, Ana Vega, Huo Yong
Journal: Journal of the American College of Cardiology (2015)
TCT-349 Predictive Value of the Syntax Score for the Occurrence of Periprocedural Myocardial Infarction in the TWENTE Trial
Authors: Kenneth Tandjung, Ming Kai Lam, Hanim Sen, Mounir W. Basalus, Gert van Houwelingen, Martin G. Stoel, Hans W. Louwerenburg, F. de Man, Gerard C. Linssen, Mark B. Nienhuis, Rogier Nijhuis, Clemens von Birgelen
Journal: Journal of the American College of Cardiology (2013)
Pneumocystis carinii pneumonia.
Authors: J T Macfarlane, R G Finch
Journal: Thorax (1985)

Pneumocystis carinii pneumoniaThe first description of pneumocysts is credited to Chagas' in 1909, who mistook them for trypano- somes in guineapig lungs.Carini reported similar structures in rat lungs infected with Trypanosoma cruzi.Subsequently Dr and Madame Delanoe in Paris found pneumocysts in sewer rats without trypanosomiasis and proposed the name Pneumocystis carinii in honour of the Brazilian Carini.'Although Chagas probably reported the first human case of pneumocystosis, its importance was not recognised until the second world war, when outbreaks of pneumonia occurred throughout Europe in malnourished children in overcrowded orphanages.23 Histologically, the lungs of such patients showed considerable mononuclear cell interstitial infiltration and foamy vacuolated alveolar exudates.The condition was named interstitial plasma cell pneumonia.A definite association with P carinii infection was made in 1952.4Subsequently, pneumocystis pneumonia was diagnosed in infants with congenital immunodeficiency states.Epidemic pneumocystis pneumonia has virtually disappeared from Europe, but is still recognised in parts of the world where malnutrition and poverty prevail.' 2 5Until recently pneumocystis pneumonia largely affected patients receiving immunosuppressive treatment and corticosteroids for cancer, organ transplantation, and other conditions.Reports from 1981 onwards, however, detailed the association between pneumocystis pneumonia, other opportunistic infections, and Kaposi's sarcoma in previously well homosexual men and drug abusers.6The acquired immune deficiency syndrome (AIDS) has caused intense interest in the medical and lay press.Recently, 169 cases of AIDS have been recorded in the United Kingdom, 762 in Europe, and 8495 in the United States (Communicable Disease Surveil- lance Center, 1985, unpublished), As pneumocystis pneumonia is by far the commonest opportunistic infection (85%) in AIDS, clinicians and micro-
Researchers got it right in estimating numbers of doctors lost from NHS
Authors: M. Goldacre, T. Lambert
Journal: BMJ (1999)

<h3>Abstract</h3> The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated whether the individual was infected or not would be highly desirable. Coagulaopathies are a common accompaniment to COVID-19, especially micro-clots within the lungs. We show here that microclots can be detected in the native plasma of COVID-19 patient, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. This provides a rapid and convenient test (P&lt;0.0001), and suggests that the early detection and prevention of such clotting could have an important role in therapy.
779 PF-03491390 PAN-CASPASE INHIBITOR DECREASES LIVER INJURY AND FIBROSIS IN A MURINE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS (NASH)
Authors: F.J. Barreyro, S. Holod, P.V. Finocchietto, A. Avagnina, A.M. Camino, C.M. Biondo, J.B. Aquino, M.C. Carreras, J.J. Poderoso, G.J. Gores
Journal: Journal of Hepatology (2010)
Combined Endoscopic Ultrasound and Stimulated Biliary Drainage in Cholecystitis and Microlithiasis - Diagnoses and Outcomes
Authors: J. E. Dill, S. Hill, J. Callis, L. Berkhouse, P. Evans, D. Martin, S. T. Palmer
Journal: Endoscopy (1995)

It is becoming increasingly evident from a number of studies that endoscopic ultrasound (EUS) is much more sensitive in the diagnosis of cholecystitis than transabdominal ultrasound (TUS). The present study was undertaken to further evaluate this relative sensitivity.Sixty-six patients with biliary-type pain and a negative transabdominal ultrasound examination underwent combined endoscopic ultrasound and stimulated biliary drainage (EUS/SBD). Stimulated biliary drainage was obtained following intraduodenal infusion of magnesium sulfate or intravenous sincalide, a CCK analogue. EUS was considered positive if sludge or small stones were seen in the gallbladder. Stimulated biliary drainage was considered positive if calcium bilirubinate granules or cholesterol crystals were seen on microscopic examination of aspirated bile.At operation, 61 of the patients had cholecystitis documented histologically. Fifty-eight of the patients had gallbladder sludge or small stones on EUS. One patient had a negative EUS, but had calcium bilirubinate granules in the bile. Twenty-one patients were followed post-operatively for a period of seven to 17 months, with an average of 10.5 months. Nineteen patients (90.5%) remain free of biliary pain.Combined endoscopic ultrasound and stimulated biliary drainage (EUS/SBD) had a high sensitivity of 92.4% and a positive predictive value of 100% in the diagnosis of cholecystitis when transabdominal ultrasound was negative. A significant majority (90.5%) of patients with positive EUS/SBD who underwent cholecystectomy had resolution of their biliary pain.
Malaria Acquired 13 Times in Two Years in Germany
Authors: Jürgen F.J. Kun, Peter G. Kremsner, Harald Kretschmer
Journal: New England Journal of Medicine (1997)

To the Editor: A 45-year-old German hospital-laboratory technician spent her holiday in Tanzania in March 1994 under malaria prophylaxis with chloroquine and proguanil (chloroguanide). In October 1...
Need for Caution in Interpretation of Western Blot Tests for HIV
Authors: Sophie Roy
Journal: JAMA (1987)

<h3>To the Editor.—</h3> With widespread use of screening programs for antibodies against the human immunodeficiency virus (HIV) in blood banks since July 1985, the number of cases of reported false seropositivity is increasing. Modifications in the screening strategies should be strongly considered to avoid the psychological trauma suffered by falsely seropositive blood donors. We report a case that further underlines the urgent need for controlled diagnostic tests. <h3>Report of a Case.——</h3> A 55-year-old asymptomatic woman was advised by the Montreal Red Cross that she was seropositive for HIV, as determined by an enzyme-linked immunosorbent assay (ELISA) and confirmed by a Western blot test.<sup>1</sup>The most probable source of contamination was her husband, who had received 3 units of blood while undergoing surgery in our hospital two years previously. The husband's serum was sent to our laboratory, but no antibodies against HIV were detected by either ELISA or indirect immunofluorescence.
Leukemia and Lymphoma Patients Linked by Prior Social Contact
Authors: STEPHEN C. SCHIMPFF
Journal: Annals of Internal Medicine (1976)

A case-control approach was used to evaluate whether patients with leukemia or lymphoma have a greater than expected tendency to have had prior close personal associations. Two census enumeration districts in different states with low population mobility were chosen, and each resident who had developed leukemia or lymphoma during a predetermined fixed interval was ascertained by review of tumor registry records. For each patient, a resident of the area was selected as a control matched for age, sex, race, and geographic location as of the time of diagnosis. Close personal associations between patients, controls, and both were determined by interviewing. In Area 1 the 8 patients had 11 social links (3 direct, 8 indirect) and the controls had 2 (both direct); P = 0.0156, one-tailed significance test. In Area 2, the 21 patients had 21 close links (15 direct, 6 indirect) whereas the controls had 10 (direct 8, indirect 2; 0.25 > P > 0.20).
HMG-CoA Reductase Inhibitor Simvastatin Profoundly Improves Survival in a Murine Model of Sepsis
Authors: Marc W. Merx, Elisa A. Liehn, Uwe Janssens, Rudolf Lütticken, Jürgen Schrader, Peter Hanrath, Christian Weber
Journal: Circulation (2004)

Background— HMG-CoA reductase inhibitors, such as simvastatin, have been shown to exhibit pronounced immunomodulatory effects independent of lipid lowering but to date have not been used to treat severe inflammatory disease such as sepsis. We thus approached the question of whether treatment with simvastatin might improve cardiovascular function and survival in sepsis. Methods and Results— Mice treated with simvastatin and rendered septic by cecal ligation and perforation (CLP) show a mean survival time close to 4 times the value found in untreated mice. This dramatic improvement is based on a complete preservation of cardiac function and hemodynamic status, which are severely impaired in untreated CLP mice [eg, 20 hours after CLP, cardiac output declined from 1.24±0.09 to 0.87±0.11 mL · min −1 · g −1 in untreated mice ( P &lt;0.005; n=12), while remaining unaltered (1.21±0.08 mL · min −1 · g −1 at baseline and 1.15±0.1 mL · min −1 · g −1 20 hours after CLP, P =NS, n=12) in CLP mice treated with simvastatin]. Untreated CLP mice remained refractory to β-stimulation, whereas the responsiveness to dobutamine was restored by treatment with simvastatin. Susceptibility of coronary flow to endothelial nitric oxide synthase (eNOS) stimulation by bradykinin was close to 3 times as pronounced in untreated CLP mice as in untreated sham-operated mice, indicating a high level of eNOS activation secondary to sepsis. In addition, treatment with simvastatin reversed inflammatory alterations in CLP mice, namely, increased monocyte adhesion to endothelium. Conclusions— Simvastatin, which is well established in the treatment of lipid disorders and coronary artery disease, might have the additional potential of being an effective agent in sepsis treatment.