tbuckley/cabot-search huggingface dataset:
Recovery of a normal coronary vascular reserve after rejection therapy in acute human cardiac allograft rejection.
Authors: A Nitenberg, O Tavolaro, C Benvenuti, D Loisance, J M Foult, L Hittinger, A Castaigne, J P Cachera, P Vernant
Journal: Circulation (1990)

During acute rejection, coronary vascular reserve is severely impaired in human orthotopic heart transplants. To evaluate the effects of rejection therapy on coronary vascular reserve, the ratio of peak-to-resting coronary flow velocity was assessed with a coronary Doppler catheter and a maximally vasodilating dose of intracoronary papaverine (12 mg) in nine allograft recipients without rejection (group 1) and in six recipients before and after treatment of an acute episode of rejection (group 2). All the patients had normal epicardial coronary arteries and were free of left ventricular hypertrophy. In group 2 during rejection, the coronary vascular reserve was significantly lower than in group 1, in which all the patients had a peak-to-resting coronary flow velocity ratio greater than 4 (2.3 +/- 0.5 vs. 5.4 +/- 0.8, respectively, p less than 0.001). In group 2 after treatment of rejection, the peak-to-resting coronary flow velocity ratio was similar to that of group 1 (4.7 +/- 0.8). Heart rate, left ventricular volumes and pressures, hemoglobin concentration, and arterial oxygen pressure were similar in the two groups. This study provides evidence that alterations of coronary vascular reserve because of acute rejection were reversible after treatment of the rejection episode.
Digoxin Intoxication and Hyperkalemia-Reply
Authors: Darrell D. Fanestil
Journal: JAMA (1980)

<h3>In Reply.—</h3> We do not agree with Dr Josephson that potassium infusion is "accepted therapy" in digoxin overdose, even though poisoned membrane transport is associated with reduced intracellular potassium levels. Potassium therapy in the presence of borderline or frank hyperkalemia is a two-edged sword whose possibly favorable therapeutic effects (raised threshold of myocardial excitation)<sup>1</sup>are balanced by (1) accentuation of underlying conduction defects,<sup>2</sup>(2) failure to repair the faulty ATPase-dependent membrane transport system, and (3) risk of complete loss of cardiac electrical activity, such that pacemaker therapy is ineffective in initiating a contractile response.<sup>3</sup>Potassium infusion in massive digoxin overdose is contraindicated as a blind maneuver and potentially hazardous in the face of high-normal to elevated serum potassium levels. This treatment would be indicated in the presence of hypokalemia or low-normal potassium levels, though only with continuous ECG monitoring. Our patient was treated with hemodialysis to reduce
Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on occlusive thrombosis elicited by endothelial cell injury or by deep vascular damage in canine coronary arteries.
Authors: G Vandeplassche, C Hemans, A Van de Water, R Xhonneux, L Wouters, K Van Ammel, F De Clerck
Journal: Circulation Research (1991)

In open-chest dogs, cyclic flow reductions (CFRs, 5.1-6.6/hr in controls; n = 24) caused by platelet deposition/dislodgment at sites of endothelial cell injury in critically stenosed left anterior descending coronary arteries (59% flow reduction) were attenuated to the same extent either by single thromboxane A2 (TXA2) synthase inhibition (0.31 mg/kg i.v. ridogrel; CFR, 0.16 +/- 0.16/hr; n = 6; p less than 0.05) or by a comparatively modest degree of TXA2/prostaglandin endoperoxide receptor antagonism on top of TXA2 synthase inhibition (5 mg/kg i.v. ridogrel; CFR, 0.22 +/- 0.1/hr; n = 10; p less than 0.05). By contrast, occlusive thrombosis on deep vascular damage elicited by intraluminal stimulation (150-microA anodal constant current) in nonpreconstricted canine coronary arteries (time to occlusion, 237.1 +/- 13.9 minutes; n = 7; incidence of occlusion within 300 minutes, six of seven experiments) was not affected by platelet cyclooxygenase inhibition (5 mg/kg i.v. acetylsalicylic acid; n = 7), single TXA2 synthase inhibition (1.25 mg/kg i.v. ridogrel; n = 7), or single TXA2/prostaglandin endoperoxide receptor antagonism (10 mg/kg + 10 mg/kg/hr i.v. sulotroban for 300 minutes; n = 5). However, such an occlusive thrombus formation was significantly reduced by combined TXA2 synthase/prostaglandin endoperoxide receptor inhibition (5 mg/kg i.v. ridogrel; time to occlusion greater than 300 minutes, n = 7; incidence of occlusion within 300 minutes, one of seven experiments; p less than 0.05). This study reveals 1) a differential efficacy of TXA2 synthase inhibition, singly or combined with TXA2/prostaglandin endoperoxide receptor antagonism, depending on the extent of the vessel wall lesion triggering thrombosis and the size of the thrombus required to obstruct the vascular lumen and 2) a significant synergism in preventing occlusive thrombosis of extensively damaged coronary arteries between strong TXA2 synthase inhibition and comparatively modest TXA2/prostaglandin endoperoxide receptor antagonism with ridogrel.
FIBROMA OF VAGINA RESEMBLING CYSTOCELE
Authors: Hamlin Mattson
Journal: JAMA (1934)

Soft fibromas are found especially in the skin and mucous membranes. About 200 cases of fibromyoma of the vagina have been reported.1Such tumors may occur at any age, though usually they are found between the ages of 20 and 50 years.2They are situated usually in the midline, and four out of five are in the anterior wall, it has been estimated.3Such tumors exhibit central expansive growth, rarely attain more than moderate size and rarely become malignant. The blood vessels supplying such tumors grow out from the capillaries of the surrounding normal tissue.4Hence the tumor tissue is prone to degeneration, softening and ulceration. Because of such characteristics it is possible that tumors of this type are assumed to be cystoceles and rectoceles and are overlooked more often than has hitherto been suspected. Werner3and more recently Downing5have pointed out the
MEETING OF THE BOARD OF TRUSTEES.
Authors: John H. Rauch
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessment of care of children with sickle cell disease.
Authors: C Barton, M Michael, J Richmond
Journal: BMJ (1990)

attendance of those invited was poor.The resulta reduction of population mortality from breast cancer of 29% in women aged 55 plus-despite the poor attendance is actually most impressive for this seven year (relatively early) analysis of results.It is in line with those of the other randomised trials of screening in Scandinavia and New York.
Polish lessons on alcohol policy.
Authors: R Smith
Journal: BMJ (1982)

The diagnosis of Crohn's disease in childhood has been facilitated by the use of fibreoptic endoscopy with biopsies, complemented by double-contrast radiology.Clinical suspicion leads initially to several relevant blood tests.These are followed by endoscopy and multiple colonic biopsies or barium follow-through studies depending on whether large-bowel or small-bowel disease is suspected.The present approach to diagnosis is based on corroborative investigative techniquesendoscopy, radiology, and histology.The availability of paediatric colonoscopes of small diameter should make it possible for paediatricians to perform limited exam- inations, but when more extensive endoscopy is indicated the child should be referred to special centres.
Systemic Therapy of Disseminated Myeloma in Passively Immunized Mice Using Measles Virus-infected Cell Carriers
Authors: Chunsheng Liu, Stephen J Russell, Kah-Whye Peng
Journal: Molecular Therapy (2010)

Multiple myeloma (MM) is bone marrow plasma cell malignancy. A clinical trial utilizing intravenous administration of oncolytic measles virus (MV) encoding the human sodium-iodide symporter (MV-NIS) is ongoing in myeloma patients. However, intravenously administered MV-NIS is rapidly neutralized by antiviral antibodies. Because myeloma cell lines retain bone marrow tropism, they may be ideal as carriers for delivery of MV-NIS to myeloma deposits. A disseminated human myeloma (KAS 6/1) model was established. Biodistribution of MM1, a myeloma cell line, was determined after intravenous infusion. MM1 cells were found in the spine, femurs, and mandibles of tumor-bearing mice. Lethally irradiated MM1 cells remained susceptible to measles infection and transferred MV to KAS 6/1 cells in the presence of measles immune sera. Mice-bearing disseminated myeloma and passively immunized with measles immune serum were given MV-NIS or lethally irradiated MV-NIS-infected MM1 carriers. The antitumor activity of MV-NIS was evident only in measles naive mice and not in passively immunized mice. In contrast, survivals of both measles naive and immune mice were extended using MV-NIS-infected MM1 cell carriers. Hence, we demonstrate for the first time that systemically administered cells can serve as MV carriers and prolonged survival of mice with pre-existing antimeasles antibodies. Multiple myeloma (MM) is bone marrow plasma cell malignancy. A clinical trial utilizing intravenous administration of oncolytic measles virus (MV) encoding the human sodium-iodide symporter (MV-NIS) is ongoing in myeloma patients. However, intravenously administered MV-NIS is rapidly neutralized by antiviral antibodies. Because myeloma cell lines retain bone marrow tropism, they may be ideal as carriers for delivery of MV-NIS to myeloma deposits. A disseminated human myeloma (KAS 6/1) model was established. Biodistribution of MM1, a myeloma cell line, was determined after intravenous infusion. MM1 cells were found in the spine, femurs, and mandibles of tumor-bearing mice. Lethally irradiated MM1 cells remained susceptible to measles infection and transferred MV to KAS 6/1 cells in the presence of measles immune sera. Mice-bearing disseminated myeloma and passively immunized with measles immune serum were given MV-NIS or lethally irradiated MV-NIS-infected MM1 carriers. The antitumor activity of MV-NIS was evident only in measles naive mice and not in passively immunized mice. In contrast, survivals of both measles naive and immune mice were extended using MV-NIS-infected MM1 cell carriers. Hence, we demonstrate for the first time that systemically administered cells can serve as MV carriers and prolonged survival of mice with pre-existing antimeasles antibodies.
Topical stratum corneum lipids accelerate barrier repair after tape stripping, solvent treatment and some but not all types of detergent treatment
Authors: L. YANG, M. MAO-QlANG, M. TALJEBINI, P.M. ELIAS, K.R. FEINGOLD
Journal: British Journal of Dermatology (2006)

Journal Article Topical stratum corneum lipids accelerate barrier repair after tape stripping, solvent treatment and some but not all types of detergent treatment Get access L. YANG, L. YANG Department of Medicine and Dermatology, University of California, San Francisco, Metabolism Section, Medical ServiceDermatology Service, Department of Veterans Affairs Medical Center, Sun Francisco, California, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. MAO‐QlANG, M. MAO‐QlANG Department of Medicine and Dermatology, University of California, San Francisco, Metabolism Section, Medical ServiceDermatology Service, Department of Veterans Affairs Medical Center, Sun Francisco, California, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. TALJEBINI, M. TALJEBINI Department of Medicine and Dermatology, University of California, San Francisco, Metabolism Section, Medical ServiceDermatology Service, Department of Veterans Affairs Medical Center, Sun Francisco, California, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar P.M. ELIAS, P.M. ELIAS Department of Medicine and Dermatology, University of California, San Francisco, Metabolism Section, Medical ServiceDermatology Service, Department of Veterans Affairs Medical Center, Sun Francisco, California, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar K.R. FEINGOLD K.R. FEINGOLD Department of Medicine and Dermatology, University of California, San Francisco, Metabolism Section, Medical ServiceDermatology Service, Department of Veterans Affairs Medical Center, Sun Francisco, California, U.S.A. Dr K.R.Feingold, Metabolism Section (111F), Department of Veterans Affairs Medical Center. 4150 Clement Street, San Francisco, CA 94121, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 5, 1 November 1995, Pages 679–685, https://doi.org/10.1111/j.1365-2133.1995.tb02738.x Published: 01 November 1995 Article history Accepted: 07 December 1994 Published: 01 November 1995
CYTOCHEMICAL STUDIES ON THE KIDNEY
Authors: N. B. Kurnick
Journal: The Journal of Experimental Medicine (1951)

Determinations of the desoxyribonucleic acid (DNA) content of the kidneys of growing rats were made on the whole tissues and on isolated nuclei. It was found that the DNA content per nucleus is constant in rats of different weights. The DNA content of the kidneys increased proportionately to their mass over the range studied. It is concluded that increase in mass is primarily due to cell multiplication.
The Neurobiologic Mechanisms in Manipulative Therapy
Authors: W. Nimmer
Journal: JAMA (1980)

This is a stimulating book presenting insights into the goals and uses of manipulative therapy. It documents the opinions of practitioners of many disciplines who ordinarily do not meet. Both clinical experiences and scientific methodologies are discussed. Questions are raised that should stimulate new and different approaches. One is impressed with the amount of research and thinking that has gone into explaining the effectiveness of manipulative therapy. Nevertheless, further work is needed both in research and integration of the findings. More documentation especially is needed from the practitioner. There appears to be a genuine need for standardization of terminology between different disciplines. Much should also be done with controlled studies either with human or animal models. This enlightening book is well worth reading. To date, most of what has been written has consisted of individual concepts, experiences, and anecdotes.
Abstract 4636: AMF-1c-120: an antibody specific for misfolded prion protein expressed on ovarian cancer cells.
Authors: Marni D. Uger, Viengthong Chai, Veronica Ciolfi, Hui Chen, Ewa Plawinski, Tapfuma Mutukura, Andrew Sage, Ryan Demers, Leo Lau, Pierre Lee, Xiuwen Liu, Jun Guan, Yuzhuo Wang, William C. Guest, Steven S. Plotkin, Neil R. Cashman
Journal: Cancer Research (2013)

Abstract We tested the hypothesis that cancer cells might display misfolded protein molecules at the cell surface, due to oxidative covalent modifications, defective glycosylation, and/or other factors relevant to cancer. We developed a computational algorithm to predict regions of proteins which were most likely to undergo loss of structure and resemble free unstructured peptides against which antibodies could be generated and screened. Antibodies directed against these misfolding-prone regions, termed disease-specific epitopes (DSEs), are therefore expected to recognize cancer cells while sparing natively folded proteins on healthy cells. We have applied this strategy to develop an antibody that is specific for ovarian cancer cells, which does not bind to normal ovarian epithelium. Using the ProMIS™ computational algorithm to predict unstable regions in proteins, three DSEs in the prion protein (PrP) were identified. Ultra-high sensitivity antibodies are required for binding to isolated misfolded protein molecules at the cell surface, and thus rabbits were immunized with peptides corresponding to the PrP DSE sequences and rabbit monoclonal anti-peptide antibodies were generated. One antibody, AMF-1c-120, has sub-nanomolar binding affinity for denatured PrP, but does not bind to native PrP. AMF-1c-120 binds to four ovarian tumor cell lines and one ovarian tumor implanted and propagated in mice, but does not bind to normal ovarian epithelial cells. Proteinase K sensitivity of the AMF-1c-120 epitope is consistent with partial denaturation of PrP at the cell surface of ovarian cancer cell lines. Preclinical efficacy studies are in progress to investigate the anti-tumor effects of AMF-1c-120. Citation Format: Marni D. Uger, Viengthong Chai, Veronica Ciolfi, Hui Chen, Ewa Plawinski, Tapfuma Mutukura, Andrew Sage, Ryan Demers, Leo Lau, Pierre Lee, Xiuwen Liu, Jun Guan, Yuzhuo Wang, William C. Guest, Steven S. Plotkin, Neil R. Cashman. AMF-1c-120: an antibody specific for misfolded prion protein expressed on ovarian cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4636. doi:10.1158/1538-7445.AM2013-4636
Pemphigoid excoriée: a further variant of bullous pemphigoid?
Authors: None Allan, None Tidman
Journal: British Journal of Dermatology (1999)

Journal Article Pemphigoid excoriée: a further variant of bullous pemphigoid? Get access S.J.R. Allan, S.J.R. Allan Department of Dermatology, Royal Infirmary of Edinburgh NHS Trust, Edinburgh EH3 9YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.J. Tidman M.J. Tidman Department of Dermatology, Royal Infirmary of Edinburgh NHS Trust, Edinburgh EH3 9YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 3, 1 September 1999, Pages 585–586, https://doi.org/10.1046/j.1365-2133.1999.03072.x Published: 01 September 1999
Sterilization and Menstrual Disturbances
Authors: Lidia M. Rubinstein
Journal: JAMA (1977)

ABSTRACT To the Editor.— The incidence of subsequent gynecological disease, particularly dysfunctional bleeding, following sterilization by tubal ligation has been extensively studied. Whether laparoscopic tubal coagulation is associated with menstrual irregularities is still an open question.We were interested in the report discussed in MEDICAL NEWS (237:2457, 1977) where women who had sterilization by laparoscopy and diathermy appeared far more likely to suffer from menstrual irregularities.We had reported (Contraception 13:631,1976) a long-term postoperative follow-up on 93 patients who had laparoscopic tubal sterilization between 1972 and 1973. Prelaparoscopy menstrual histories were compared with menstrual histories 18 to 36 months after laparoscopic tubal cauterization. After sterilization, regular periods were reported by 78.5% of the patients; 2.1% had amenorrhea; 8.6% had preoperative menstrual irregularities unchanged after the procedure; 5.4% had changes in the menstrual cycle related to discontinuation of oral contraceptives; and only 5.4% reported abnormal periods since the sterilization procedure. Our clinical
Evaluation of Blood Donors with Elevated Serum Alanine Aminotransferase Levels
Authors: LAWRENCE S. FRIEDMAN
Journal: Annals of Internal Medicine (1987)

We evaluated 100 asymptomatic blood donors with serum alanine aminotransferase (ALT) levels exceeding 0.83 µkat/L, for evidence of liver disease or risk factors for non-A, non-B hepatitis and followed serum ALT levels for another 6 months. In 92 donors completing the study, ALT elevations occurred once in 33%, intermittently in 36%, persistently in 28%. Twenty-two donors were obese, 5 had clinical and biochemical evidence of alcoholic liver disease, and 45 drank alcohol regularly; 1 had hemochromatosis, and another, myopathy. In 22 no cause for elevated serum ALT levels was found. The presence or absence of risk of acquiring hepatitis did not correlate with the pattern of ALT elevations or the identification of another cause for the elevated ALT levels. In 92 blood donors with an initially elevated ALT level, two-thirds have intermittent or persistent elevations; most are obese or use alcohol regularly, or both; and approximately 20% have no apparent cause for the elevations other than possible non-A, non-B hepatitis. These findings may be helpful in counseling and following blood donors with elevated ALT levels.
Cerebellar Tumor or Masturbation.
Authors: C. V. Moots
Journal: JAMA (1899)

Delphos, Ohio, May 13, 1899. <h3>To the Editor:</h3> —In the last issue of theJournal, p. 1027, R. C. Cabot, M.D., describes a case, and asks, "Can all the symptoms of this case be explained by the masturbation?" I would say emphatically, "No." The masturbation was a result, not a cause. The treatment or nature removed the cause, and then the mental impression received at the hospital enabled him to cease the practice.
Comparative evaluation between two immunoenzymatic techniques (FAST and Phadezym) and the Phadebas RAST in food allergy
Authors: D. A. Moneret‐Vautrin, J. L. Gueant, A. Abdel‐Ghani, Y. Maria, J. P. Nicolas
Journal: Allergy (1990)

The diagnosis of food IgE‐dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positive RAST to a food allergen). The within‐run variation coefficient of class 0–2 sera was 9% for the Phadebas RAST, and higher than 20 % for the Phadezym and the FAST. It was in order of 8.7%, 9.4% and of 17.6% &gt; respectively for Phadebas RAST, Phadezym and FAST when estimated with class 3–4 sera. The specificity was higher than 95 % for the three techniques. The sensitivity was 75% for Phadebas and 43% for Phadezym and FAST. The FAST test is much less sensitive with allergens of vegetal origin than those of animal origin (P &lt; 0.01). This work indicates the high percentage of false negative results of immunoenzymatic techniques when food extracts are tested. This could be explained either by an enzyme‐substrate reaction or by a non‐specific inhibition of the enzyme linked to the anti‐IgE IgG.
Embolism to the Bifurcation of the Aorta
Authors: Chilton Crane
Journal: New England Journal of Medicine (1958)

SUDDEN occlusion of the aortic bifurcation by embolic clot released from the heart constitutes one of the rare but dramatically important emergency situations seen in medical practice. If such a clot is sufficiently firm and bulky to remain impacted at this level, and if the obstruction to arterial flow is virtually complete, high demarcation of color and temperature, with extensive loss of nerve and muscle function, will follow promptly, constituting a grave threat to both lower limbs and to the patient's life. Under these circumstances of total aortic occlusion, procrastination by the patient in seeking medical help is rare. If . . .