tbuckley/cabot-search huggingface dataset:
Cat, dog, and house‐dust‐mite allergen levels of house dust in Finnish apartments
Authors: P. Raunio, A.‐L. Pasanen, M. Reiman, T. Virtanen
Journal: Allergy (1998)

The presence of indoor allergetis iti Finnish homes was studied for the first time. Dust samples (n=30) were collected by vacuuming a 1 m 2 area from a living‐room carpet in 30 apartments divided into three groups: homes with cats (n = 10), homes with dogs (n = 10). and homes without pets (n=10). The levels of major cat (Fel d 1). dog (Can f 1), and house‐dust‐mite (Der p 1) allergens were analyzed by two‐site ELISA methods. Der p 1 levels were below the detection limit in all dust samples. In the homes with cats or dogs, Fel d 1 and Can f 1 levels ranged from 147 to 2800 μg/g (geometric mean 567 μg/g), and from 86 to 1400 μg/g (geometric mean 296 μg/g), respectively, being slightly higher than those reported elsewhere. Low allergen levels, mainly below 3 (μg/g. were also detected in the homes without pets, indicating the transfer of allergens from place to place. However, in 25% of these samples, allergen levels exceeded the proposed threshold levels for cat or dog sensitization. The presence of pets was the most significant factor affecting cat and dog allergen levels in the house dust, and other factors, such as the amount of dust collected, residential time, and cleaning habits, had no or only a weak effect on allergen levels.
Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC
Authors: S J Busfield, M Biondo, M Wong, H S Ramshaw, E M Lee, S Ghosh, H Braley, C Panousis, A W Roberts, S Z He, D Thomas, L Fabri, G Vairo, R B Lock, A F Lopez, A D Nash
Journal: Leukemia (2014)
Screening for Abdominal Aortic Aneurysm: A Best-Evidence Systematic Review for the U.S. Preventive Services Task Force
Authors: Craig Fleming, Evelyn P. Whitlock, Tracy L. Beil, Frank A. Lederle
Journal: Annals of Internal Medicine (2005)

Background: While the prognosis for abdominal aortic aneurysm (AAA) rupture is poor, ultrasound imaging is an accurate and reliable test for detecting AAAs before rupture. Purpose: To examine the benefits and harms of population-based AAA screening. Data Sources: MEDLINE (1994 to July 2004) supplemented by the Cochrane Library, a reference list of retrieved articles, and expert suggestions. Study Selection: Randomized trials of AAA population screening, population studies of AAA risk factors, and data on adverse screening and treatment events from randomized trials and cohort studies. Data Extraction: All studies were reviewed, abstracted, and rated for quality by using predefined criteria. Data Synthesis: The authors identified 4 population-based randomized, controlled trials of AAA screening in men 65 years of age and older. On the basis of meta-analysis, an invitation to attend screening was associated with a significant reduction in AAA-related mortality (odds ratio, 0.57 [95% CI, 0.45 to 0.74]). A meta-analysis of 3 trials revealed no significant difference in all-cause mortality (odds ratio, 0.98 [CI, 0.95 to 1.02]). No significant reduction in AAA-related mortality was found in 1 study of AAA screening in women. Screening does not appear to be associated with significant physical or psychological harms. Major treatment harms include an operative mortality rate of 2% to 6% and significant risk for major complications. Limitations: The population screening studies focused on men and provided no information on racial or ethnic groups. No information was available on uninvited control group characteristics, so the importance of risk factors such as tobacco use or family history could not be assessed. Since all trials were conducted in countries other than the United States, generalizability to the U.S. population is uncertain. Conclusion: For men age 65 to 75 years, an invitation to attend AAA screening reduces AAA-related mortality.
546. Mesenchymal Stromal Cells Are Promising Candidates as Delivery Vehicles for Systemic Oncolytic Measles Virotherapy in Models of Acute Lymphoblastic Leukaemia
Authors: A Castleton, E Ghorani, C Zhang, A Dey, B Patel, L Rai, M Ehlam, A Fielding
Journal: Molecular Therapy (2012)
BITES OF SERPENTS.
Authors: E. Ingals
Journal: JAMA (1883)

In the article on the Medical and Surgical Practice of the Aborigines of America, contributed by F. Andros, M.D., and published in your issue of Aug. 4, it is stated that some tribes apply the bruised wild onion for the stings of bees and wasps. I am not aware that any similar practice has been recommended in the literature of our profession, though the juice of the common onion is an excellent application for this purpose. It should be thoroughly applied to the wound immediately after the sting has been received. It acts as a very perfect antidote to the poison, prevents swelling and speedily relieves the pain. No treatment for the bite of the rattlesnake could be better than the Indian practice of sucking the wound; and this involves no danger to the operator, for the venom is innocuous when taken into the stomach. The Indians probably acted wisely
Blood transfusions in the therapy of a case of prolidase deficiency
Authors: E. BERARDESCA, D. FIDELI, M. BELLOSTA, K.M. DYNE, G. ZANABONI, G. CETTA
Journal: British Journal of Dermatology (1992)

A case is reported of a 15-year-old boy with prolidase deficiency and marked urinary excretion of the iminodipeptide gly-pro. Prolidase activity of erythrocytes against substrate glycyl-proline was deficient, but after blood transfusions this was increased to 15.7% of donor activity and declined to 12% and 3.4% of normal activity after 8 and 45 days, respectively. Urinary iminodipeptide levels following transfusion remained unaltered.
Gastric emptying of two radiolabelled antacids.
Authors: J Mones, I Carrio, M Roca, M Estorch, R Calabuig, S Sainz, C Martinez-Duncker, F Vilardell
Journal: Gut (1991)

The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled antacids. The studies were carried out on 15 healthy male volunteers. After an eight hour fast each subject ingested a standardised meal of 95.7 MJ (400 kcal). One hour later 10 ml of one of the two antacids previously labelled with 99mTc was administered. Serial detection by anterior and posterior projection of the amount of antacid retained in the stomach was performed to determine gastric emptying of antacid. One week later the study was repeated under the same conditions with the other antacid also labelled with 99mTc. The mean (SD) percentages of antacid retained in the stomach fit a linear model with a t1/2 of 86.6 (15.3) minutes for magaldrate and 52.3 (5.2) minutes for Maalox (p less than 0.01). When the mean percentages of retention at six time intervals were compared for both antacids, it was found that Maalox emptied much faster (p less than 0.01 at 15 and 30 minutes, p less than 0.02 at 45, 60, 75, and 90 minutes).
Early onset of Varicella Zoster Virus Reactivation (VZV, Shingles) in Patients with Autosomal Dominant Hyper IgE Syndrome (AD-HIES)
Authors: J. Heimall, A.M. Siegel, P.A. Shaw, A. Hsu, S.M. Holland, A.F. Freeman, J.D. Milner
Journal: Journal of Allergy and Clinical Immunology (2011)
Migraine: a follow-up study of 92 patients.
Authors: C. W. Whitty, J. M. Hockaday
Journal: BMJ (1968)

It has been a commonly held view that migraine attacks tend to cease as time passes and that such improvement occurs particularly after the menopause in women.However, we have found no published work on the natural history of the condition over periods of more than a few years which might lend support to this view.We therefore studied a group of migraine patients followed for periods of 15 to 20 years who, when finally assessed, had been subject to the condition for 16 to 69 years.We inquired for changes in frequency and severity of attacks and in the pattern of individual attacks, and sought to find out if these showed any consistent relation to advancing years, to the menopause, or to intercurrent illness, especially the development of hypertension or cervical spondylosis.This paper presents our findings. Materil and MethodsFrom the total of 1,304 patients with migraine who attended the neurology depattment at the Radcliffe Infirmary up to 1966 those who had been first seen and in whom the diagnosis was established before 1952 were selected for follow-up.Criteria for the diagnosis of migraine were that the patient should have recurring throbbing headaches and, in addition, two of the following five features: unilateral headache, asso-- ciated nausea with or without vomiting, visual or other sensory aura, cyclical vomiting in childhood, and a family history of tnigraine (Whitty, Hockaday, and Whitty, 1966), There were 121 such patients.Five of them had died (two of carcinoma, one of glioma, and two of unknown causes).Twenty-four were not traced.Of the remaining 92 patients 53 were women and 39 men.All replied to a detailed ques- tionary, and all were either reported on by their family doctor or exained personally. Results Changes in Frequency and SeverityIn 63 patients attacks were still occurring at the time of follow-up.In two information was inadequate.Twenty-seven TABLE I.-Age at Follow-up and Persistence of Attacks Age Attacks Persist
Effects of Greek economic crisis on health are real
Authors: A. Kentikelenis, M. Karanikolos, I. Papanicolas, S. Basu, M. McKee, D. Stuckler
Journal: BMJ (2012)

We were surprised by Liaropoulos’s conclusions about the health effects of the Greek economic crisis.1 His article contains several unreferenced assertions and contradictions, such as statements that there is “no evidence of denial of services to patients” yet “many [people] are without cover” and the church, non-governmental associations, and others are “rallying to help.”

He …
US health reform bill will hinder introduction of generic forms of biological drugs, critics say
Authors: J. H. Tanne
Journal: BMJ (2009)

<h3>ABSTRACT</h3> Bulk and single-cell analyses of the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) have revealed a largely immunosuppressive milieu. Thus far, efforts to utilize insights from TME features to facilitate more effective therapeutics have largely failed. Here, we performed single-cell RNA sequencing (scRNA-seq) on a cohort of treatment-naive PDAC time-of-diagnosis endoscopic ultrasound-guided fine needle biopsy samples (n=22) and surgical samples (n=6), integrated with 3 public datasets (n=49), resulting in ∼140,000 individual cells from 77 patients. Based on expression markers assessed by Seurat v3 and differentiation status assessed by CytoTRACE, we divided the resulting tumor cellular clusters into 5 molecular subtypes based on expression of previously reported marker genes: Basal, Mixed Basal/Classical, Classical Low, Classical High, and ADEX. We then queried these 5 tumor cell profiles, along with 15 scRNA-seq-derived tumor microenvironmental cellular profiles, in 391 bulk expression samples from 4 published datasets of localized PDAC with associated clinical metadata using CIBERSORTx. Through unsupervised clustering analysis of these 20 cell state fractions representing tumor, leukocyte and stromal cells, we identified 7 unique clustering patterns representing combinations of tumor cellular and microenvironmental cell states present in PDAC tumors. We termed these cell state patterns communities, and found them to correlate with overall survival, tumor ecotypes, and tumor cellular differentiation status. The community associated with worst overall survival contained basal tumor cells, exhausted CD4 and CD8 T cells, and was enriched for fibroblasts. In contrast, the highest overall survival was associated with a community high in immune cell enrichment. The differentiation state of tumor cells (assessed by CytoTRACE) was also correlated with survival in a dose-dependent fashion. Further, we identified a subset of PDAC samples that were significantly enriched for CD8 T and plasma cells that achieved a 2-year overall survival rate of 71%, suggesting we can identify PDAC patients with significantly improved prognoses and, potentially, higher sensitivity to immunotherapy. In summary, we identified novel tumor microenvironmental communities from high-dimensional analysis of PDAC RNA sequencing data that reveal new connections between tumor microenvironmental composition and patient survival that could lead to better upfront risk stratification and more personalized clinical decision-making.
Systemic mastocytosis in adults: 2011 update on diagnosis, risk stratification, and management
Authors: Animesh Pardanani
Journal: American Journal of Hematology (2011)

Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in one or more extracutaneous organs.The major criterion is presence of multifocal clusters of morphologically abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC expression of CD25 and/or CD2, and presence of KITD816V.The prognostic relevance of the 2008 World Health Organization (WHO) classification of SM has recently been confirmed. Classification of SM patients into indolent (SM), aggressive SM (ASM), SM associated with a clonal non-MC lineage disease (SM-AHNMD), and mast cell leukemia (MCL) subgroups is a useful first step in establishing prognosis.SM treatment is generally palliative. ISM patients have a normal life expectancy and receive symptom-directed therapy; infrequently, cytoreductive therapy may be indicated for refractory symptoms. ASM patients have disease-related organ dysfunction; interferon-α (±corticosteroids) can control dermatological, hematological, gastrointestinal, skeletal, and mediator-release symptoms, but is hampered by poor tolerability. Similarly, cladribine has broad therapeutic activity, with particular utility when rapid MC debulking is indicated; the main toxicity is myelosuppression. Imatinib has a therapeutic role in the presence of an imatinib-sensitive KIT mutation or in KITD816-unmutated patients. Treatment of SM-AHNMD is governed primarily by the non-MC neoplasm; hydroxyurea has modest utility in this setting. Dasatinib's in vitro anti- KITD816V activity has not translated into significant therapeutic activity in most SM patients. In contrast, preliminary data suggest that Midostaurin may produce significant decreases in MC burden in some patients.
Resolving "Kinks" of Chemotherapy in Melanoma
Authors: S. J. Moschos, P. M. Chaudhary, J. M. Kirkwood
Journal: JNCI Journal of the National Cancer Institute (2008)

JNCI | Editorials 833 A recent review of our last 35 years of phase 2 clinical trials for metastatic melanoma demonstrates that there has been no statistically significant improvement in 1-year overall survival or 6-month progression-free survival with any intervention tested in multicenter trials to date ( 1 ). An understanding of the basis of failure for these tested agents has generally been lacking, and few of these trials involved laboratory corollary studies of mechanism. Many cell survival and death pathways that are dysregulated in melanoma [reviewed in ( 2 )] and other new pathways that might explain the refractoriness of melanoma to current treatments are under exploration ( 3 ). Melanoma repopulating (stem) cells that are resistant to chemotherapy may also be culpable ( 4 ). Targeting molecules critical for melanoma cell survival in rational combinations may improve the efficacy of chemotherapy, and this is currently being tested in relation to sorafenib. Nuclear factor kappa B (NF B) is the general designation for a family of dimeric complexes of members of the Rel protein family, which are important in melanoma [reviewed in ( 5 , 6 )]. This transcription factor is activated in response to diverse stimuli, including proinfl ammatory cytokines, “nonself” antigens, lymphocyte mitogens, and cellular stress (ultraviolet and ionizing radiation, as well as chemotherapeutic agents). In resting cells, NFB remains cytoplasmic through its association with one of three inhibitory I  B proteins (I  B , I  B , or I B ). It can be activated through at least three different pathways. The canonical pathway exhibits rapid kinetics and is dependent on the stimulation of the inhibitor of I B kinase (IKK), a complex composed of the enzyResolving “Kinks” of Chemotherapy in Melanoma
European Commission is not paying its share towards TB research, charity says
Authors: P. Moszynski
Journal: BMJ (2008)

The European Commission is failing to pay its fair share towards developing new vaccines, diagnostic tools, and treatments for tuberculosis, says the international healthcare charity Medecins Sans Frontieres (MSF) in a new report.

The charity insists that more needs to be done to fight the disease in the face of a global epidemic that claims 1.7 million lives a year, and it is calling on the European Commission to increase its research funding fivefold.

“Because the tests and drugs we use today aren’t anything like effective enough, MSF teams responding to the epidemic in Africa and Asia are faced with an almost …
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
Authors: Ramiro Garzon, Stefano Volinia, Chang-Gong Liu, Cecilia Fernandez-Cymering, Tiziana Palumbo, Flavia Pichiorri, Muller Fabbri, Kevin Coombes, Hansjuerg Alder, Tatsuya Nakamura, Neal Flomenberg, Guido Marcucci, George A. Calin, Steven M. Kornblau, Hagop Kantarjian, Clara D. Bloomfield, Michael Andreeff, Carlo M. Croce
Journal: Blood (2008)
A Logical Approach to Screening for Coronary Artery Disease
Authors: ROBERT DETRANO
Journal: Annals of Internal Medicine (1987)

Although changes in lifestyle may increase the life expectancy of persons at high risk for coronary disease, there is no cost-effective screening test that can select these persons from the general population. Exercise testing has been considered, but epidemiologic studies have not proved that it effectively identifies persons at risk for myocardial infarction or cardiac death. Theoretically, exercise testing should have limited sensitivity in predicting events because abnormal responses occur only when sufficient atherosclerotic plaque has accumulated to impede coronary flow. Abnormal test responses cannot occur before plaque has reached such dimensions. A test that indicates the presence of any atherosclerotic plaque in the coronary lumen would be more useful than one that indicates compromise of blood flow. Data show that sensitive detection of coronary calcific deposits accurately predicts the presence of atherosclerotic plaque. Sensitive radiographic techniques such as digital subtraction fluoroscopy need to be developed as screening tests. Screening studies should be blinded and include only hard endpoints, and follow-up periods should be no less than 10 years so that the detected disease can develop to its symptomatic endpoint.
The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region
Authors: Philippe Jay, Claire Rougeulle, Annick Massacrier, Anne Moncla, Marie-Geneviève Mattel, Perrine Malzac, Nathalie Roëckel, Sylvie Taviaux, Jean-Louis Bergé Lefranc, Pierre Cau, Philippe Berta, Marc Lalande, Françoise Muscatelli
Journal: Nature Genetics (1997)
Persistent Hypokalemia Following Open-Heart Surgery
Authors: PAUL A. EBERT, JAMES R. JUDE, ROBERT A. GAERTNER
Journal: Circulation (1965)

Six patients who exhibited persistent hypokalemia after open-heart surgery with a dilute blood perfusion mixture are discussed. All these patients had acquired heart disease with heart failure as their predominant problem and had been on long-term diuretic treatment with oral potassium replacement. It was not possible to predict with any degree of certainty which patients would develop hypokalemia postoperatively, but the clinical points discussed indicated that frequent measurement of serum potassium was necessary until the value appeared stable. The authors think that the hypokalemia results from long-term tissue potassium depletion, and that hemodynamic improvement following open-heart surgery may facilitate the return of potassium into the cells and thus reduce the serum level.
CONTINUED USE OF DIGITALIS IN PATIENTS WITH REGULAR RHYTHM"
Authors: Henry A. Christian
Journal: JAMA (1933)

To the Editor:  —Any one who has interested himself in tracing back to original sources statements subsequently attributed to an author is struck by the frequency with which ideas are attributed to authors which are quite remote from the meaning of the statement originally made by this same author. Something of this sort will be found in the editorial inThe Journal, June 3, entitled the Continued Use of Digitalis in Patients with Regular Rhythm, in which the idea is attributed to me of having suggested that digitalis was a specific like thyroid in myxedema and liver in pernicious anemia. What I actually said was that, like these two forms of therapy, digitalis therapy, if started as suggested in my paper inThe Journal, March 18, should be continued throughout life, which is entirely a different proposal from that attributed to me in the editorial referred to.
Benzene-Associated Myelofibrosis
Authors: HOWARD HU
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 January 1987Benzene-Associated MyelofibrosisHOWARD HU, M.D., M.P.H.HOWARD HU, M.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-1-171_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A patient was recently seen in our occupational medicine clinic whose case illustrates a little-known effect of chronic benzene poisoning and emphasizes the continuing need for clinicians to improve their history taking concerning occupational and environmental exposures.A 54-year-old woman was referred with a history of working in a handbag factory for 23 years and a chronic hematologic disease. In an unventilated room in the factory, she ran a cementing machine that glued felt inside handbags. The patient frequently used a cleaning solvent to wipe off excess glue and to clean the glue machine at the end...References1. GALL E. Benzene poisoning with bizarre extramedullar hematopoiesis. Arch Pathol. 1938;25:315. Google Scholar2. RAWSONPARKERJACKSON RFH. Industrial solvents as possible etiologic agents in myeloid metaplasia. Science. 1941;93:541. CrossrefMedlineGoogle Scholar3. AKSOYERDEMDINCOL MSG. Two rare complications of chronic benzene poisoning: myeloid metaplasia and paroxysmal nocturnal hemoglobinuria. Blut. 1975;30:255. CrossrefMedlineGoogle Scholar4. SILVERSTEIN M. Agnogenic myeloid metaplasia. In: WILLIAMS WJ, BEUTLER E, ERSLEV AJ, LICHTMAN MA, eds. Hematology. 3rd ed. New York: McGraw-Hill Book Co.; 1983:214-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byShanghai Health Study (2001–2009): What was learned about benzene health effects?Myélofibrose primitiveIdiopathic myelofibrosis: pathogenesis to treatmentAgnogenic Myeloid Metaplasia Terminating in Acute Megakaryoblastic Leukemia3 Pathogenesis and management of idiopathic myelofibrosisPathogenesis of Idiopathic Myelofibrosis: A ReviewHigh Incidence of Myeloproliferative Disorders in Ashkenazi Jews in Northern IsraelToluene ? associated myelofibrosisMyelofibrosis and Focal Segmental Glomerulosclerosis Associated with Toluene PoisoningBenzene Exposure and Systemic SclerosisLÁSZLÓ CZIRJAK, M.D., GYULA SZEGEDI, M.D.Chronic Idiopathic Myelofibrosis 1 January 1987Volume 106, Issue 1Page: 171-172KeywordsHistory of medicine Issue Published: 1 January 1987 PDF downloadLoading ...