tbuckley/cabot-search huggingface dataset:
Interaction of Aluminum Hydroxide and Allopurinol in Patients on Chronic Hemodialysis
Authors: IRITH WEISSMAN
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 November 1987Interaction of Aluminum Hydroxide and Allopurinol in Patients on Chronic HemodialysisIRITH WEISSMAN, M.D., NORBERTO KRIVOY, M.D.IRITH WEISSMAN, M.D.Search for more papers by this author, NORBERTO KRIVOY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-5-787_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report the cases of three patients on chronic hemodialysis treated concomitantly by aluminum hydroxide and allopurinol for high uric acid and phosphate concentration. Initially the uric acid blood concentration did not change; allopurinol was then given 3 hours before the aluminum hydroxide, and there was a decrease in uric acid concentration.A 21-year-old woman receiving hemodialysis was given allopurinol, 300 mg/d, concomitantly with aluminum hydroxide, 5.7 g/d. After 1 month of combined therapy the uric acid concentration was 25.7 mg/dL. She was advised to allow 3 hours between the aluminum hydroxide and allopurinol. One month later...References1. MCEVOY G, ed. American Hospital Formulary Service: Drug Information. Washington, D.C.: American Society of Hospital Pharmacists; 1987:1498-504. Google Scholar2. PRESCOTT L. Clinically important drug interactions. In: AVERY GS, ed. Drug Treatment. Australia: Adis Press; 1980:236-62. Google Scholar3. MONKCAMPOLI-RICHARDS JD. Ofloxacin, a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1987:33:346-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: IRITH WEISSMAN, M.D.; NORBERTO KRIVOY, M.D.Affiliations: Rambam Medical Center Haifa Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAllopurinolAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and goutGastrointestinal drugs 1 November 1987Volume 107, Issue 5Page: 787-787KeywordsAllopurinolAttentionBloodPhosphatesUric acid ePublished: 1 December 2008 Issue Published: 1 November 1987 PDF downloadLoading ...
MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer
Authors: Jan C. Dudda, Bruno Salaun, Yun Ji, Douglas C. Palmer, Gwennaelle C. Monnot, Estelle Merck, Caroline Boudousquie, Daniel T. Utzschneider, Thelma M. Escobar, Rachel Perret, Stefan A. Muljo, Michael Hebeisen, Nathalie Rufer, Dietmar Zehn, Alena Donda, Nicholas P. Restifo, Werner Held, Luca Gattinoni, Pedro Romero
Journal: Immunity (2013)
LONGEST AVAILABLE (UP TO SEVEN YEARS) EXPERIENCE WITH DRUG-ELUTING STENTS FOR NON-SELECTED COMPLEX PATIENTS: ASSESSING THE INDEPENDENT PREDICTORS OF NEGATIVE EVENTS IN THE DESIRE REGISTRY
Authors: Jose de Ribamar Costa, Amanda Sousa, Adriana Moreira, Ricardo Costa, Manuel Cano, Galo Maldonado, Cantídio Campos nNeto, Mariana Carballo, J Eduardo Sousa
Journal: Journal of the American College of Cardiology (2010)
On the Treatment of Stricture of the Urethra
Authors: W. F. Teevan
Journal: BMJ (1871)

Sol ments of some patients, a twist of the specialist's sound has sometimes rectified a long overlooked twist of the womb.Such tales recall to my memory the boasted achievements of the magician's wand, or the magic touch of the bone-setter's art.I cannot say that this speedy rectifica- tion of uterine twists accords with my experience, even when the sound and pessary have been used under the guidance of th; respected leaders
Government announces "safe sex" campaign for England
Authors: C. White
Journal: BMJ (2001)

The government has finally issued its long awaited draft proposals to modernise sexual health and HIV services and tackle the rising prevalence of sexually transmitted infections in England.

The national strategy for sexual health and HIV will be accompanied by a new national safer sex information campaign in 2002 and spending of £47.5m in the next two years.

The move coincides with publication of the latest figures from the Public Health Laboratory Service, which show that the upward trend in sexually transmitted infections since 1995 continues unabated, with large and increasing numbers of new diagnoses in teenage girls and in men who have …
Psychosis and antithyroid drug therapy.
Authors: A. J. Hedley, P. D. Bewsher
Journal: BMJ (1969)

for any published account of these misfortunes, which are presumably theoretical.I have used the gingival sulcus route of administration of oxytocin with complete success, and, may I dare to suggest, much greater comfort, satisfaction, and safety to the patients.'Ritchie and Brudenell have also published papers describing the satisfactory use of oxytocin administered by absorption through the buccal mucous membrane.2' It would be interesting to know why absorption of a drug through the buccal mucosa is more dangerous than giving the same drug intravenously.-Iam, etc., Croydon,
Olanzapine-Induced Weight Gain in Patients With First-Episode Schizophrenia: A Double-Blind, Placebo-Controlled Study of Fluoxetine Addition
Authors: Michael Poyurovsky, Artashes Pashinian, Irit Gil-Ad, Rachel Maayan, Michael Schneidman, Camil Fuchs, Abraham Weizman
Journal: American Journal of Psychiatry (2002)

OBJECTIVE: Since olanzapine-induced weight gain may be attributable to the antagonistic activity of olanzapine at the serotonin-2C receptor, the authors hypothesized that it might be attenuated by addition of the selective serotonin reuptake inhibitor fluoxetine. METHOD: First-episode hospitalized schizophrenia patients (N=30) were randomly assigned in an 8-week double-blind study of olanzapine, 10 mg/day, coadministered with either fluoxetine, 20 mg/day (N=15), or placebo (N=15). RESULTS: The group receiving olanzapine plus fluoxetine showed significantly less improvement in positive and disorganized symptom dimensions than the group receiving olanzapine plus placebo. The two groups demonstrated similar and substantial gradual weight gains. CONCLUSIONS: These results suggest that fluoxetine coadministration is clinically ineffective and cannot attenuate olanzapine-induced weight gain.
Predictive Value of Lipoprotein and Cholesterol Determinations in Diabetic Patients who Developed Cardiovascular Complications
Authors: ALEXANDER D. LOWY, JOSEPH H. BARACH, Zdenek Hrubec
Journal: Circulation (1958)

A follow-up study was performed on 690 white diabetic patients 2 to 5 years after their blood had been analyzed for lipoprotein and cholesterol to determine if these lipid measures had any predictive value for development of future cardiovascular complications. The work was done in parallel to the national project in which 15,000 normal persons were followed for 1 to 2 years. 5
Medicine at Center Stage
Authors: Jerome P. Kassirer
Journal: New England Journal of Medicine (1993)

I have never seen a time in the past four decades when so much attention has been paid to medicine. Not a day goes by without a story on television, in the newspapers, or in popular magazines about medical care or its organization. Hardly a story begins without a reminder that we not only fail to take good care of all of our populace, but are also breaking the national bank -- and the President and Congress seem poised to do something about it. With all the attention, this should be an extraordinary opportunity for us as physicians to define . . .
Control of Fibrinolysis During Portacaval Shunts
Authors: Carlo E. Grossi, Louis M. Rousselot, William F. Panke
Journal: JAMA (1964)

In a series of 240 patients with cirrhosis of the liver, surgery for correction of portal hypertension was done in 102 who had bled from esophageal varices or had intractable ascites. Uncontrollable oozing developed during surgery in 13, all of whom had hypofibrinogenemia and high fibrinolytic activity of the plasma. Intravenous use of e-aminocaproic acid resulted in arrest of oozing and permitted completion of surgery in 11 patients. The fibrinolytic inhibitor was used successfully also to control postoperative bleeding from unusual sites. Evaluation of coagulation factors is recommended in patients with chronic liver disease undergoing surgery.
Myocardial Blood Flow Distribution during Ischemia-Induced Coronary Vasodilation in the Unanesthetized Dog
Authors: Robert J. Bache, Frederick R. Cobb, Joseph C. Greenfield
Journal: Journal of Clinical Investigation (1974)

This study was designed to determine whether coronary vasodilation distal to a flow-limiting coronary artery stenosis could result in redistribution of myocardial blood flow to produce subendocardial underperfusion. Studies were performed in 10 awake dogs chronically prepared with electromagnetic flow-meters and hydraulic occluders on the left circumflex coronary artery. Regional myocardial blood flow was measured using radionuclide-labeled microspheres, 7-10 mum in diameter, injected into the left atrium. A 5(-s) coronary artery occlusion was followed by reactive hyperemia with excess inflow of arterial blood effecting 375+/-20% repayment of the blood flow debt incurred during occlusion. When, after a 5(-s) occlusion, the occluder was only partially released to hold arterial inflow to the preocclusion level for 20 s before complete release, the delayed reactive hyperemia was augmented (mean blood flow repayment = 610+/-45%, P < 0.01). This augmentation of the reactive hyperemia suggested that ischemia was continuing during the interval of coronary vasodilation when coronary inflow was at the preocclusion level. Measurements of regional myocardial blood flow demonstrated that endocardial flow slightly exceeded epicardial flow during control conditions. When arterial inflow was limited to the preocclusion rate during vasodilation after a 5(-s) total coronary artery occlusion, however, flow to the subepicardial myocardium was increased at the expense of underperfusion of the subendocardial myocardium. Thus, in the presence of a flow-limiting proximal coronary artery stenosis, ischemia-induced coronary vasodilation resulted in redistribution of myocardial blood flow with production of subendocardial ischemia in the presence of a net volume of arterial inflow which, if properly distributed, would have been adequate to prevent myocardial ischemia.
THE MEDICAL TREATMENT OF INEBRIETY.
Authors: T D Crothers
Journal: JAMA (1896)

Inebriety is a more complex disease than insanity. Its progressive degeneration often dates back to ancestors, to defects of growth, retarded development and early physical and psychic injuries. Later, the poison of alcohol, by its anesthetic and paralyzing action, develops more complex states of degeneration, the form and direction of which is very largely dependent on conditions of living and surroundings. The psychic symptoms show progressive disease of the higher brain centers, both masked and open, with degrees of palsy and lowered vitality. In insanity many definite pathologic conditions are traceable. In inebriety a wider, more complex range of causes appear, the line of march of which is often traceable in more general laws of dissolution. Its medical treatment must be based on some clear idea of what inebriety is, and the conditions present in the case to be treated. This requires a careful clinical study of the symptoms, tracing
Bodily Complaints and Other Symptoms of Depressive Reaction
Authors: John D. Stoeckle
Journal: JAMA (1962)

Medical clinic patients with "functional" bodily complaints were commonly found to have a depressive reaction. This reaction consists of bodily symptoms and disturbances in relations, both interpersonal (withdrawl, irritability, and resentment) and intrapersonal (depressed mood, loss of pleasure in usual activities, helplessness, and injured self-esteem). The diagnosis is made on the history of a traumatic event which the patient perceives as a loss, rather than on symptoms alone. Diagnosis is important because the bodily symptoms are commonly used as a reason for coming to the doctor, because care of the patient demands recognition of all aspects of his illness, and because rational treatment depends on it. Treatment involves several roles of the doctor and his explicit or implicit use of some psychotherapeutic techniques in his medical practice. Four case histories illustrate these principles.
Diabetes and Cholesterol Metabolism
Authors: Norman H. Ertel
Journal: Diabetes Care (2003)

In the recent article by Simonen et al. (1) demonstrating increased cholesterol synthesis in obese patients with diabetes, the authors did not consider a possible mechanism suggested by the “succinate hypothesis,” which is elegantly summarized by Fahien and MacDonald (2) in a separate article. Fahien and MacDonald showed that succinate esters are potent insulin secretagogues (almost as potent as glucose) through generation of succinyl-CoA (S-CoA). This seemed to …
Percutaneous interventions in radial artery grafts: Clinical and angiographic outcomes
Authors: Arvind Sharma, Andrew E. Ajani, Edouard F. Cheneau, Nidhi Garg, Afework GebreEyesus, Lowell F. Satler, Augusto D. Pichard, Ellen Pinnow, Ron Waksman, Joseph Lindsay
Journal: Journal of the American College of Cardiology (2003)
Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.
Authors: T D Gelehrter, R Sznycer-Laszuk
Journal: Journal of Clinical Investigation (1986)

We have examined the effect of thrombin on the activity of plasminogen activator (PA) and plasminogen activator-inhibitor (PA-I) in medium conditioned by primary cultures of human umbilical vein endothelial cells. PA activity was measured by fibrinolytic and esterolytic assays, and total tissue-type PA (tPA) antigen by radioimmunoassay. Net PA-I activity was assayed by titration of human urokinase esterolytic activity. Incubation of confluent endothelial cell cultures with thrombin for 24 h caused a sixfold increase in PA-I activity. The effect of thrombin was half-maximal at approximately 0.4 U/ml (less than 4 nM), and required concomitant RNA and protein synthesis. The stimulation of PA-I activity required active alpha-thrombin and was not obtained with gamma-thrombin nor with thrombin catalytically inactivated with hirudin. Because of the excess of PA-I, PA activity was not measurable in either control or thrombin-treated cells. Thrombin did, however, increase medium concentration of tPA antigen by approximately fourfold. The thrombin-induced PA-I inhibited both tPA and urokinase, did not lose activity upon acidification, and was stable to sodium dodecyl sulfate and thiol reduction. We conclude that physiologic concentrations of thrombin increase both PA-I activity and tPA antigen in medium conditioned by human umbilical vein endothelial cells. Because there was always a several-fold increase in the net activity of free PA-I, these observations suggest that the net effect of thrombin is to decrease fibrinolytic activity in human endothelial cells. Thus, thrombin, in addition to its role in coagulation, may protect clots from premature lysis by increasing the amount of a specific fibrinolytic inhibitor.
Intense Accumulation of F-18 FDG in Colonic Wall in Adult Onset Still Disease With Pseudomembranous Colitis
Authors: Byeong-Cheol Ahn, Sang-Woo Lee, Jaetae Lee
Journal: Clinical Nuclear Medicine (2008)

Pseudomembranous colitis (PMC) is a severe form of Clostridium difficile associated diarrhea (CDAD), and it occurs more frequently in immunosuppressed patients. Accurate and early diagnosis is important in the successful management of CDAD. Adult onset Still disease (AOSD) has an unknown etiology and is characterized by fever, rash, and arthritis. There is no single diagnostic test for AOSD; therefore, diagnosis is based on clinical criteria and exclusion of infectious, neoplastic, and autoimmune diseases. Diagnosis of PMC requires a high index of clinical suspicion in a hospitalized patient with diarrhea, fever, and leukocytosis, but diarrhea could not be included because of associated paralytic ileus. We describe a case of diffuse FDG uptake in the rectosigmoid colonic wall in AOSD patient with PMC. In this case, the PET/CT finding was a first clue for diagnosis of CDAD in this case because fever and leukocytosis were already present due to underlying AOSD.
Insulin Resistance — A Secret Killer?
Authors: Daniel W. Foster
Journal: New England Journal of Medicine (1989)

In his Banting Lecture in 1988, Reaven coined the term "Syndrome X" to describe the following constellation: resistance to insulin-stimulated glucose uptake, glucose intolerance, hyperinsulinemia, increased levels of very-low-density lipoprotein (VLDL) triglyceride, decreased levels of high-density lipoprotein (HDL) cholesterol, and hypertension.1 The phenomenon of insulin resistance is well known in obesity, polycystic ovary syndrome, diabetes mellitus, lupus and other autoimmune diseases characterized by antibodies to the insulin receptor, partial or complete lipodystrophy, rare disorders such as leprechaunism, and a variety of endocrine diseases.2 It is generally considered to be secondary in these conditions, with a reversion to normal if the . . .
Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts
Authors: Jens M. Kelm, Maximilian Y. Emmert, Armin Zürcher, Dörthe Schmidt, Yvonne Begus Nahrmann, Karl L. Rudolph, Benedikt Weber, Chad E. Brokopp, Thomas Frauenfelder, Sebastian Leschka, Bernhard Odermatt, Rolf Jenni, Volkmar Falk, Gregor Zünd, Simon P. Hoerstrup
Journal: Biomaterials (2012)
Neurology Simplified: A Practical Approach to the Early Diagnosis and Treatment of Neurologic Diseases Written Especially for General Practitioners and Students
Authors: John H. Raach
Journal: JAMA (1961)

This book is primarily for general practitioners, internists, and advanced medical students. It is a good outline of neuropathology. The chapters are organized according to the pathology, diagnosis, symptoms, signs, treatment, and, in many instances, illustrative case reports. There are brief discussions of headache, pain syndromes, cerebrovascular disorders, epilepsies, multiple sclerosis, and miscellaneous neurological conditions. For those out of contact with the academic phase of medicine, the chapter on various supplemental studies useful in pinpointing the neurologic diagnosis is helpful. There is also a good summary of the acceptable way of doing a thorough neurological examination. For those who have become "rusty" in things neurological or who are just learning, this is a timely primer.
Effects of synchronized retroperfusion on the coronary arterial pressure-flow relationship
Authors: M Mitsugi
Journal: Cardiovascular Research (1996)

We compared the effects of diastolic coronary sinus pressure elevation due to synchronized retroperfusion (SRP) with systolic coronary sinus pressure elevation due to coronary sinus occlusion on the coronary pressure-flow relationship under similar mean coronary sinus pressure values.Using isolated, perfused canine hearts, coronary perfusion of the left anterior descending artery was reduced gradually, setting the mean coronary sinus pressure to 14.2 +/- 5.7 mmHg (mean +/- s.d.) under control conditions, 30.3 +/- 4.9 mmHg under SRP with lower retrograde perfusion flow [SRP(L)], 30.7 +/- 4.6 mmHg under coronary sinus partial occlusion [CSPO], 51.9 +/- 7.9 mmHg under SRP with higher retrograde perfusion flow [SRP(H)] and 49.0 +/- 7.9 mmHg under coronary sinus complete occlusion [CSCO]. Zero-flow pressure and the slopes of pressure-flow relationship were determined in each condition.The mean values of the slopes did not significantly differ among the interventions. The mean control value of zero-flow pressure was 17.4 +/- 4.3 mmHg. Zero-flow pressure of SRP(L) was 20.0 +/- 3.5 mmHg, which was not a significant increase, whilst zero-flow pressure of CSPO was 22.9 +/- 3.4 mmHg, a significant increase compared with control (P < 0.05). Zero-flow pressure of SRP(H) and CSCO was 26.0 +/- 4.5 and 31.3 +/- 6.7 mmHg, respectively, and both were significantly higher than control (P < 0.01). Zero-flow pressure of SRP(H) was, however, significantly lower than CSCO (P < 0.05).SRP, which causes diastolic coronary sinus pressure elevation, does not greatly affect coronary arterial inflow, compared with coronary sinus occlusion which causes systolic coronary sinus pressure elevation. These results suggest that the blood volume contained in the heart during systole plays a role in determining coronary inflow. Therefore, SRP intervention, which does not interfere with venous outflow during systole, may ameliorate injured myocardium during ischaemia without seriously affecting coronary inflow supply.
531 TENOFOVIR DF TREATMENT IS SAFE AND WELL TOLERATED IN CHRONIC HEPATITIS B (CHB) PATIENTS WITH BASELINE DECREASED GLOMERULAR FILTRATION RATE
Authors: P. Marcellin, F. Zoulim, X. Causse, C. Hézode, D. Larrey, G. Pageaux, B. Roche, R. Truchi, D. Ouzan, A. Pauwels, J. Dumortier, C. Stern, O. Libert, J.-F. Cadranel, J.-P. Zarski
Journal: Journal of Hepatology (2012)
Continuous, low‐dose therapy with interferon‐α for human immunodeficiency virus (HIV)‐related immune thrombocytopenic purpura
Authors: Donald W. Northfelt, Lawrence D. Kaplan, Donald I. Abrams
Journal: American Journal of Hematology (1991)

Abstract A patient with HIV‐related immune thrombocytopenic purpura (HIV‐ITP) had a rapid rise in platelet count when treated with interferon‐α2b, 3 million units three times weekly. There were no significant toxicities with therapy. His platelet count fell to pretreatment levels when therapy was discontinued, then increased again when therapy was reinstituted at 1.5 million units three times weekly. Interferon‐α2b, administered continuously at low doses, is well tolerated, effective, and possibly less immunosuppressive than other treatments for HIV‐ITP.
THE FUNCTION OF THE KIDNEYS IN PATIENTS SUFFERING FROM CHRONIC CARDIAC DISEASE WITHOUT SIGNS OF HEART FAILURE
Authors: Harold J. Stewart, John F. McIntosh
Journal: Journal of Clinical Investigation (1928)

This study is concerned with the function of the kidneys in patients suffering from chronic heart disease during periods when they show no signs of heart failure.Studies of renal function during attacks of heart failure have of course been numerous.With the introduction of each new test of renal function its usefulness in cardiac patients has been explored, often however without attempting to correlate it with other tests already in use.Following the introduction of phenolsulphonephthalein by Rown- tree and Geraghty (1912), investigations by Rowntree, Fitz and Ger- aghty (1913), Rowntree and Fitz (1913), Rowntree, Marshall and Baetjer (1915), Frothingham and Smile (1914) and Agnew (1915) were published.The outcome of all these studies is the same, namely, that excretion of this substance is much reduced, if there is a marked degree of chronic passive congestion; with restoration of compensation excretion again becomes normal.McLean (1915) studied these cases from a slightly different point of view.Instead of measuring the ex- cretion of a substance introduced from without, he estimated a natural function, in this case urea excretion and found that the index of ureas excretion was low during decompensation, but increased as the signs of heart failure disappeared.As an indication of the state of the circula- tion, it ran parallel to the test of Rowntree and Geraghty (1912).In all these investigations the emphasis has been placed more or less upon the state of the kidneys as a phase of heart failure.Important though it is to be aware of this matter, it is equally, perhaps more important to know whether the kidneys are essentially damaged or whether their behavior merely reflects the state of the whole organism, caught as it is, in the process of heart failure.For this reason we have examined the