Myocardial Lactate Metabolism in Coronary Insufficiency
Authors: NORMAN KRASNOW
Journal: Annals of Internal Medicine (1963)

Article1 December 1963Myocardial Lactate Metabolism in Coronary InsufficiencyNORMAN KRASNOW, M.D., RICHARD GORLIN, M.D.NORMAN KRASNOW, M.D., RICHARD GORLIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-781 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCharacterization of coronary insufficiency has improved significantly in the last 20 years. In addition to clarification of the diverse clinical syndromes (1, 2), diagnostic abnormalities both in the resting and in the stress electrocardiogram have been carefully documented. Recently, the introduction of coronary arteriography has permitted visualization of the diseased vessels during life (3). On the other hand, relatively little attention has been paid to the functional or physiologic aspects of the syndrome as it affects the myocardium.Abnormalities in hemodynamics in subjects with coronary insufficiency have been described previously (4, 5). Studies from this laboratory have suggested that the...References1. PRINZMETALKENNAMERMERLISSWADABOR MRRTN: Angina pectoris. I. A variant form of angina pectoris. Amer. J. Med. 27: 375, 1959. CrossrefMedlineGoogle Scholar2. RESNICK WH Pre-infarction angina. Mod. Conc. Cardiov. Dis. 51: 751, 1962. Google Scholar3. SONESSHIREY FMEK Cine coronary arteriography. Mod. Conc. Cardiov. Dis. 31: 735, 1962. MedlineGoogle Scholar4. DAVISSCARBOROUGHMASONSINGEWALDBAKER FWWRREMLBM: Effect of exercise and smoking on the electrocardiograms and ballistocardiograms of normal subjects and patients with coronary artery disease. Amer. Heart J. 46: 529, 1953. CrossrefMedlineGoogle Scholar5. 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Effects of infusion of pyruvate or glucose and of hyperventilation. J. Clin. Invest. 37: 244, 1958. CrossrefMedlineGoogle Scholar11. KLINGENBERGBUCHER MT: Biological oxidations. Ann. Rev. Biochem. 29: 669, 1960. CrossrefMedlineGoogle Scholar12. COFFMANGREGG JDDE: Oxygen metabolism and oxygen debt repayment after myocardial ischemia. Amer. J. Physiol. 201: 881, 1961. CrossrefMedlineGoogle Scholar13. MESSERWAGMANLEVINENEILLKRASNOWGORLIN JVRJHJWANR: Patterns of myocardial extraction during rest and exercise. J. Clin. Invest. 41: 725, 1962. CrossrefMedlineGoogle Scholar14. WENDTSTOCKHAYDENBRUCEGUDBJARNASONBING VETPROTASRJ: Hemodynamics and cardiac metabolism—cardiomyopathies. Med. Clin. N. Amer. 46: 1445, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Medical Clinics, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts.This work was supported by The National Institutes of Health grant H-2637 from the United States Public Health Service; a grant from the Warner-Chilcott Laboratories; and grant 459 from the Massachusetts Heart Association.Requests for reprints should be addressed to Richard Gorlin, M.D., Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston 15, Massachusetts. 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OLSON, PH.D., M.D. 1 December 1963Volume 59, Issue 6Page: 781-787KeywordsAngiographyElectrocardiographyHeartHemodynamicsHospitalsIsoproterenolLactatesMedical servicesMyocardiumStable coronary artery disease Issue Published: 1 December 1963 CopyrightCopyright ©, 1963, by The American College of PhysiciansPDF DownloadLoading ...