tbuckley/cabot-search huggingface dataset:
The Lust of Slander.
Authors: H. J. Achard
Journal: JAMA (1903)

their independence in contract practice or under other disad¬ vantages.The Verband has aided the medical officers of the sickness insurance societies at Gera, Miihlhausen and elsewhere and warned other physicians not to take the places resigned by the officers on account of the intolerable conditions prevailing.The recent legislation on sickness insurance has brought num¬ bers of new recruits into the association until it now has 8,933 members.At present it has seven places on its list where it is assisting the physicians, both materially and morally, in their resistance to the degradation of the profession by the sickness insurance societies.At Constance troubles of this nature have just been satisfactorily settled, thanks to its mediation.Denunciations of Pasteur Treatment of Hydrophobia in Italy.-The Journal de Mcd. de Paris never misses an opportunity to cast discredit on Pasteur treatment, and, in fact, Lvitaud, the editor, has never accepted the science of bacteriology with the same seriousness as the rest of the medical world.The last issue of that journal contains a letter from Dr. C. Ruata, professor of hygiene at Perugia, commenting on the recent death of 4 persons at Novara who had been bitten by a rabid dog and who had taken a course of treatment at the Pasteur Institute at Milan.Ruata's communication also appears in certain Italian papers.He asserts that since the Pasteur insti¬
The Association Between Major Depression and Levels of Soluble Intercellular Adhesion Molecule 1, Interleukin-6, and C-Reactive Protein in Patients With Recent Acute Coronary Syndromes
Authors: François Lespérance, Nancy Frasure-Smith, Pierre Théroux, Michael Irwin
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: This study was conducted to determine whether or not depression is associated with higher levels of inflammatory markers in patients recovering from acute coronary syndromes. METHOD: Plasma levels of soluble intercellular adhesion molecule 1 (sICAM-1) and interleukin-6 (IL-6) and the serum level of C-reactive protein were measured in 481 patients 2 months after hospitalization for acute coronary syndromes. Diagnosis of major depression was based on the Structured Clinical Interview for DSM-IV. RESULTS: Depressed patients showed significantly higher sICAM-1 levels, a difference that remained significant after adjustment for potential confounders (gender, smoking, presence of metabolic syndrome). Although there was no significant association between depression and IL-6, there was an interaction between depression and statin therapy for levels of C-reactive protein. Depressed patients not taking statins had markedly higher C-reactive protein levels than did nondepressed patients. There was no relationship with depression in those receiving statins. CONCLUSIONS: These results suggest chronic endothelial activation among depressed patients after acute coronary syndromes. Further research is needed to determine whether or not higher levels of sICAM-1 may identify a subgroup of depressed patients at particularly high risk for cardiac events among patients with established coronary artery disease or among those without previous coronary artery disease.
Prescription Drug Use and Costs Among Diabetic Patients in Primary Health Care Practices in Germany
Authors: Wolfgang Rathmann, Burkhard Haastert, Jeffrey M Roseman, F Arnold Gries, Guido Giani
Journal: Diabetes Care (1998)

OBJECTIVE To evaluate drug prescriptions and costs among diabetic patients in primary care practices in Germany. RESEARCH DESIGN AND METHODS Computerized data on prescriptions and costs (drug company sales prices) were analyzed in 30,604 diabetic and 17,723 (5% random sample) nondiabetic patients from 362 primary care practices during 1994. Relative use ratios for drug groups were obtained from logistic regression models (odds ratio [OR] for diabetes) controlling for age, sex, and other covariates. Relative costs (diabetic:nondiabetic) were estimated by direct age and sex standardization. RESULTS Diabetic patients had an increased prescription use for most drugs. A substantial increased use (OR ≥ 1.4) was found for cardiovascular drugs, fibrates, gout medication, laxatives, and wound care products. Diabetic subjects (7.9% of all patients) accounted for 21% of total annual prescription costs in the practices. Total costs (U.S. dollars) per patient-year were threefold higher (diabetic patients $384; control subjects $123). After excluding antidiabetic agents and age- and sex-standardization, relative costs were still 1.5 times higher (P &amp;lt; 0.05). Diabetes treatment accounted for 24% of total costs in diabetic patients (insulin 12%; oral antidiabetics 6%). The most important cost factor was cardiovascular drugs (CVDs) (39%). Three CVD groups accounted for about 50% of total CVD costs in diabetic patients (ACE inhibitors 25%; Ca-antagonists 16%; nitrates 10%). CONCLUSIONS Prescription use among diabetic patients in primary health care practices was predominantly increased for cardiovascular drugs and for treatment of diabetes-associated disorders. Diabetic patients accounted for over one-fifth of the total pharmacy costs in primary practices, indicating that diabetes is a major economic factor in drug use.
Combined delivery of BMP-2 and bFGF from nanostructured colloidal gelatin gels and its effect on bone regeneration in vivo
Authors: Huanan Wang, Qin Zou, Otto C. Boerman, Arnold W.G. Nijhuis, John A. Jansen, Yubao Li, Sander C.G. Leeuwenburgh
Journal: Journal of Controlled Release (2012)
General James Wilkinson
Authors: John D. King
Journal: New England Journal of Medicine (1968)

THE notable achievements of most doctors outside the practice of medicine have generally been praiseworthy. It was otherwise with James Wilkinson, who left medicine for a military career and became one of the most controversial and, on the whole, unsavory figures of early America.Wilkinson was born in 1757 near Benedict, Maryland, the son of a wealthy planter. At the age of 14 he began the study of medicine under a relative, a physician whose fond recollections of bygone army days were of more than passing interest to his pupil. Wilkinson entered the College of Philadelphia in 1773 and graduated . . .
UNCOMMON ACCIDENTS FOLLOWING OPERATIONS IN THE NOSE AND THROAT.
Authors: MAX THORNER
Journal: JAMA (1896)

It is now almost ten years that the late Professor Nussbaum commenced his monograph "On Accidents in Surgery" with these words: "Of surgical accidents, avoidable ones as well as unavoidable, there are so many, that if one would attempt to enumerate them all one would hardly know where to begin and where to end. Unfortunately, owing to human vanity, almost exclusively successful cases are reported, while unfortunate events are not published, although one unfortunate accident is often more instructive than ten successful cases." Such considerations have prompted me to report to you to-day a number of accidents following operations in the nose and throat, which have happened during the last eleven years. I do not attempt to enumerate all or even the majority of undesirable sequelæ that I have seen; but I purposely omit all such cases, as are frequently observed and have often been described, for instance lacunar tonsillitis
1032-131 Impaired coronary circulation in patients with apical hypertrophic cardiomyopathy: Noninvasive analysis by transthoracic Doppler echocardiography
Authors: Ken Yoshida, Takeshi Hozumi, Yasuhiko Takemoto, Kenichi Sugioka, Hiroyuki Watanabe, Minoru Yoshiyama, Kazuhide Takeuchi, Junichi Yoshikawa
Journal: Journal of the American College of Cardiology (2004)
Health workers and the baby food industry
Authors: R K Anand
Journal: BMJ (1996)

jeopardising continuing research into new methods, and potentially halting further expansion of the contraceptive "menu."It is hoped that newer implants such as Norplant 2 and Implanon will soon become available.These are suitable for fur- ther groups ofusers and their progression from research, through development and licensing, to general availability has been painstakingly and carefully overseen.It would be a pity if misleading information prevented appropriate uptake and further expansion of user choice.
Abstract 3161: Non-cell autonomous regulation of collective invasion be an epigenetically distinct subpopulation of tumor cells
Authors: Amanda Prechtl, Jill Westcott, Tuyen Dang, Erin Maine, Gray Pearson
Journal: Cancer Research (2014)

Abstract Diverse genetic and epigenetic traits can promote variant behaviors in subpopulations of cells within primary tumors. In some cases, these heterogeneous subpopulations may compete against each other for clonal dominance to improve tumor fitness. By comparison, the extent to which tumor cell subpopulations cooperate during malignant progression is not well understood. Here, we find that a commensal relationship can exist between epigentically distinct subpopulations of tumor cells during collective invasion. Using quantitive phenotypic analysis and live-cell imaging, we discovered that a subpopulation of cells, termed trailblazer cells, has an enhanced ability to collectively invade. Trailblazer phenotype was heritable and trailblazer subpopulations were derived from 5 triple-negative breast cancer cell lines. The percentage of trailblazers cells within a population ranged from between 0.5% and 90% of the parental population. Gene expression profiling identified a 29-gene expression signature that distinguished trailblazer cells from non-trailblazer cells and identified patients with poor outcome, A cohort of genes trailblazer signature genes were necessary for the formation of actin-rich projections that facilitate path generation during collective invasion. In addition, the trailblazer gene DOCK10 was necessary for spontaneous metastasis to the lung. The path generating function of a small subpopulation of trailblazer cells was sufficient to induce the collective invasion of large population of naturally occurring non-trailblazer cells in organotypic culture. Trailblazer cells were also sufficient to induce the invasion of a mouse model of ductal carcinoma in situ. Taken together, our results suggest that a rare subpopulation of tumor cells with an enhanced ability to collectively invade can promote metastatic progression through cell autonomous and non-cell autonomous mechanisms. Thus, our results support a paradigm shift towards identifying both the cell autonomous and the non cell-autonomous regulatory mechanisms of cell biological processes within heterogeneous tumors to understand neoplastic progression and develop new intervention modalities. Citation Format: Amanda Prechtl, Jill Westcott, Tuyen Dang, Erin Maine, Gray Pearson. Non-cell autonomous regulation of collective invasion be an epigenetically distinct subpopulation of tumor cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3161. doi:10.1158/1538-7445.AM2014-3161
The Benign Purpuric Hyperglobulinemia of Waldenstrom
Authors: Howard J. Schwartz, Stephen B. Fredd
Journal: JAMA (1964)

SINCE WALDENSTROM'S first description in 1943<sup>1</sup>of a chronic, benign purpuric syndrome associated with a marked hypergammaglobulinemia, case reports of the entity have appeared on the continent and in the United States. The scarcity of recent reports and the relative ease of diagnosis leads us to present a case which was recently studied at University Hospital. The present patient refocuses attention on the question of whether this syndrome is in itself a primary disease entity, or a striking, somewhat unusual manifestation of an underlying disease state. <h3>Report of a Case</h3> A 49-year-old Hungarian female was admitted for medical evaluation to University Hospital on Dec 13, 1961. She was in good health until 1954 when she developed weakness, weight loss, anemia, and discolorations of the skin of the legs. Evaluation at a hospital in Hungary led to a diagnosis of dysproteinemia of unknown type, and she was given vitamins, cortisone,
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells
Authors: Yuka Nakamura, Fumio Arai, Hiroko Iwasaki, Kentaro Hosokawa, Isao Kobayashi, Yumiko Gomei, Yoshiko Matsumoto, Hiroki Yoshihara, Toshio Suda
Journal: Blood (2010)
Abstract 4332: Conditional transgenic mice for the carboxyl-terminus of MUC16
Authors: Huasong Tian, David R. Spriggs
Journal: Cancer Research (2011)

Abstract The cancer antigen 125 (CA125) is encoded by the MUC16 gene, which is present in sera of women with ovarian cancer. Currently, CA125 is widely used to diagnose the epithelial ovarian cancer and monitor the effects of treatment. Despite the widespread use of CA125, the biochemical and molecular functions of this antigen is poorly understood. There is no phenotype for MUC16 knockout mice (Cheon et al., PLoS ONE, 2009). Our previous data have demonstrated that the carboxyl-terminus of MUC16 has at least the partial functions of MUC16 since CA125 protein is too big (up to 2.5 MDa). To better understanding of the biological functions and characterizations of MUC16, we made a construct to create a conditional transgenic mouse model for the carboxyl-terminus of MUC16 using the Cre-loxP system. This mouse model encodes for the specific portion of MUC16, we named as MUC16ΔC354 mouse, which includes 354 amino acids of carboxyl-terminus of MUC16 with a HA tag. The CMV early enhancer plus chicken β actin (CAG) promoter is used to drive hGFP between two loxPs and the carboxyl-terminus of MUC16 after removing hGFP. After mating with EIIa-Cre transgenic mice, we found two founders which highly express MUC16ΔC354 in many organs, for example, brain, colon, heart, kidney, liver, lung, ovary and spleen. Lung and heart have higher expression level of MUC16ΔC354, and ovary has a middle level. MUC16ΔC354 heterozygous animals appear to be viable, fertile, and develop normally through the first four months of life. However, MUC16ΔC354 transgenic mice regulate PI3K/AKT and MAPK/ERK signaling pathways in some organs. Additional MUC16ΔC354 mice are being bred and selected for phenotypes. Cross breeding with N-Myc transgenic mice, or Rb-1 and p53 knockout mice is planned based on the preliminary results of The Cancer Genome Atlas (TCGA). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4332. doi:10.1158/1538-7445.AM2011-4332
MicroRNA-146a Downregulates NFκB Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma
Authors: Jin Ho Paik, Ji-Young Jang, Yoon Kyung Jeon, Wook Youn Kim, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim
Journal: Clinical Cancer Research (2011)

Abstract Purpose: We investigated prognostic implications of microRNAs in extranodal NK/T cell lymphoma (NKTL). Experimental Design: We measured miRNA expression in NKTL tissues and cell lines, using real-time PCR, and analyzed its role in NKTL, using cell lines. Results: Multivariate analysis showed low miR-146a expression (P &amp;lt; 0.001; HR = 13.110), primary non–upper aerodigestive tract lesion (non-UAT; P = 0.008; HR = 5.376) and high International Prognostic Index (IPI; ≥3; P = 0.013; HR = 3.584) to be independent poor prognostic factors. miR-146a expression could subdivide UAT-NKTL into 2 prognostic groups, resulting in the following prognostic groups: (i) UATLow-146a, (ii) UATHigh-146a, and (iii) non-UAT. Compared with UATHigh-146a, UATLow-146a showed distinctively poor prognosis (P &amp;lt; 0.001; HR = 15.620), similar to the non-UAT group. In vitro, miR-146a overexpression in NKTL cell lines, SNK6 and YT, inhibited nuclear factor κB (NFκB) activity, suppressed cell proliferation, induced apoptosis, and enhanced chemosensitivity. TNF receptor–associated factor 6, a target of miR-146a and a known NFκB activator, was downregulated by miR-146a in SNK6 and YT cells. Promoter methylation of miR-146a gene was observed in SNK6 and YT cells, as well as in NKTL tissues with low miR-146a expression, and miR-146a expression was induced by the conversion of methylation status with a demethylating agent in SNK6 and YT cells. Conclusions: These results suggest that miR-146a might function as a potent tumor suppressor in NKTL and be useful for patient assessment and therapeutic targeting. Clin Cancer Res; 17(14); 4761–71. ©2011 AACR.
165 DONOR/RECIPIENT BODY SURFACE AREA RATIO AS A NOVEL PREDICTOR OF GRAFT SURVIVAL AFTER DECEASED DONOR LIVER TRANSPLANTATION
Authors: S. Ginanni Corradini, M. Siciliano, A. Molinaro, M.A. Burza, C. Pirazzi, F. Ferri, M. Giusto, F. Pugliese, L. Poli, M. Merli, A.F. Attili, P.B. Berloco, M. Rossi
Journal: Journal of Hepatology (2009)
P1008 A 5.9 kDa SERUM FRAGMENT OF FIBRINOGEN a-CHAIN IS A SPECIFIC SURROGATE MARKER OF ACTIVE FIBROGENESIS IN PATIENTS WITH LIVER DISEASE
Authors: S. Marfa, G. Crespo, V. Reichenbach, X. Forns, G. Casals, M. Morales-Ruiz, M. Navasa, W. Jiménez
Journal: Journal of Hepatology (2014)
De subitaneis mortibus. XVII. Multifocal stenoses due to fibromuscular dysplasia of the sinus node artery.
Authors: T N James, T K Marshall
Journal: Circulation (1976)

The sinus node artery was focally narrowed by fibromuscular dysplasia in two examples of sudden unexpected death reported here. Although both cases had additional histological abnormalities in the conduction system of the heart, the more striking feature was the focal fibromuscular dysplasia. These findings are discussed in relationship to a large number of similar examples of focal fibromuscular dysplastic narrowing of the sinus node artery observed in other victims of sudden unexpected death, considering some possible mechanisms for lethal electrical instability of the heart and also the possible pathogenesis of such fibromuscular dysplasia.
Absence of C/EBP may cause bronchial smooth muscle proliferation in asthma
Authors: N M Rahman
Journal: Thorax (2005)

▴ Roth M, Johnson PRA, Borger P, et al . Dysfunctional interaction of C/EBPα and the glucocorticoid receptor in asthmatic bronchial smooth muscle cells. N Engl J Med2004;351:560–74 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Proliferation of bronchial smooth muscle (BSM) cells occurs in the airways of asthmatic patients. Glucocorticoids exert antiproliferative effects via CCAAT/enhancer binding protein α (C/EBPα), an antiproliferative transcription factor. This paper studies signalling pathways in BSM cell proliferation from 20 asthmatic and 26 non-asthmatic subjects (lung cancer/CF/emphysema). A series of elegant … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DRoth%26rft.auinit1%253DM.%26rft.volume%253D351%26rft.issue%253D6%26rft.spage%253D560%26rft.epage%253D574%26rft.atitle%253DDysfunctional%2BInteraction%2Bof%2BC%252FEBP%257Balpha%257D%2Band%2Bthe%2BGlucocorticoid%2BReceptor%2Bin%2BAsthmatic%2BBronchial%2BSmooth-Muscle%2BCells%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa021660%26rft_id%253Dinfo%253Apmid%252F15295049%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa021660&link_type=DOI [3]: /lookup/external-ref?access_num=15295049&link_type=MED&atom=%2Fthoraxjnl%2F60%2F4%2F281.atom [4]: /lookup/external-ref?access_num=000223069900009&link_type=ISI
Herpes Zoster and Neoplastic Disease-Reply
Authors: Paul F. Wehrle
Journal: JAMA (1976)

The estimate that "approximately 10% of patients with herpes zoster will have underlying problems" is based on personal experience on a large infectious disease service. From this experience, approximately 10% of our patients do have underlying problems either recognized or unrecognized at the time of onset of zoster. Those with extensive, recurrent, or disseminated zoster are more likely to have serious underlying problems, many identified prior to onset of zoster. In contrast, when zoster occurs among children in apparent good health, they are substantially less likely to have underlying malignant disease. The earlier comment was intended simply to alert physicians to the need for health evaluation in patients with zoster, recognizing that the frequency of predisposing conditions will vary widely, depending on the population served.
TRIM29 Suppresses TWIST1 and Invasive Breast Cancer Behavior
Authors: Lingbao Ai, Wan-Ju Kim, Merve Alpay, Ming Tang, Carolina E. Pardo, Shigetsugu Hatakeyama, W. Stratford May, Michael P. Kladde, Coy D. Heldermon, Erin M. Siegel, Kevin D. Brown
Journal: Cancer Research (2014)

Abstract TRIM29 (ATDC) exhibits a contextual function in cancer, but seems to exert a tumor-suppressor role in breast cancer. Here, we show that TRIM29 is often silenced in primary breast tumors and cultured tumor cells as a result of aberrant gene hypermethylation. RNAi-mediated silencing of TRIM29 in breast tumor cells increased their motility, invasiveness, and proliferation in a manner associated with increased expression of mesenchymal markers (N-cadherin and vimentin), decreased expression of epithelial markers (E-cadherin and EpCAM), and increased expression and activity of the oncogenic transcription factor TWIST1, an important driver of the epithelial–mesenchymal transition (EMT). Functional investigations revealed an inverse relationship in the expression of TRIM29 and TWIST1, suggesting the existence of a negative regulatory feedback loop. In support of this relationship, we found that TWIST1 inhibited TRIM29 promoter activity through direct binding to a region containing a cluster of consensus E-box elements, arguing that TWIST1 transcriptionally represses TRIM29 expression. Analysis of a public breast cancer gene-expression database indicated that reduced TRIM29 expression was associated with reduced relapse-free survival, increased tumor size, grade, and metastatic characteristics. Taken together, our results suggest that TRIM29 acts as a tumor suppressor in breast cancer through its ability to inhibit TWIST1 and suppress EMT. Cancer Res; 74(17); 4875–87. ©2014 AACR.
Clinical significance and hemodynamic correlates of the third heart sound gallop in aortic regurgitation. A guide to optimal timing of cardiac catheterization.
Authors: A M Abdulla, M J Frank, R A Erdin, M I Canedo
Journal: Circulation (1981)

The hemodynamic and clinical data of 42 patients with chronic significant aortic regurgitation and 31 normal subjects were examined. Of the patients with aortic regurgitation, 28 had a third heart sound (S3) gallop and 14 did not. There was no significant difference in the severity of regurgitation between the patients with or without an S3 gallop. However, all patients with an S3 gallop had an abnormality increased left ventricular residual volume and depressed contractile state. These findings were supported by the hemodynamic data of two patients who underwent cardiac catheterization before and after the development of an S3 gallop. We conclude that the S3 gallop in patients with chronic AR reflects left ventricular dysfunction, rather than more severe degrees of regurgitation per se, and may therefore be useful for selecting patients for cardiac catheterization and consideration for prosthetic aortic valve replacement.
Cytokeratin&amp;ndash;20 Reverse&amp;ndash;Transcriptase Polymerase Chain Reaction as a New Tool for the Detection of Circulating Tumor Cells in Peripheral Blood and Bone Marrow of Bladder Cancer Patients
Authors: M. Retz, J. Lehmann, C. R&ouml;der, K. Weichert-Jacobsen, T. Loch, E. Romahn, C. L&uuml;hl, H. Kalthoff, M. St&ouml;ckle
Journal: European Urology (2001)