Absorption of Tetracyclines: Interference by Iron
Authors: NORTON J. GREENBERGER
Journal: Annals of Internal Medicine (1971)

Editorial Notes1 May 1971Absorption of Tetracyclines: Interference by IronNORTON J. GREENBERGER, M.D.NORTON J. GREENBERGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-792 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeuvonen and his associates (1) have recently reported that ferrous sulfate taken by mouth with tetracycline or a tetracycline-derivative can impair the absorption of these antibiotics. These investigators demonstrated in human volunteers that after a single 500-mg dose of tetracycline a maximal serum concentration of 2.9 µg/ml was attained in a 6-hr period, but, when tetracycline was taken with 200 mg of FeSO4, the maximal serum levels were only 40% to 50% of levels after tetracycline alone. Similarly, ingestion of 500 mg of Oxytetracycline and 200 mg of FeSO4resulted in serum levels 50% to 60% lower than the value...References1. NEUVONENGOTHONIHACKINAN PGR: Interference of iron with the absorption of tetracyclines in man. Brit Med J 4:532-534, 1970 CrossrefMedlineGoogle Scholar2. GOODMANGILMAN LA (editors): The tetracyclines, in The Pharmacological Basis of Therapeutics. New York, The MacMillan Co., 1965 Google Scholar3. ALBERT A: Avidity of terramycin and aureomycin for metallic cations. Nature (London) 172:201, 1953 CrossrefMedlineGoogle Scholar4. ALBERTREES AC: Avidity of the tetracyclines for the cations of metals. Nature (London) 177:433-434, 1956 CrossrefMedlineGoogle Scholar5. KOHN K: Mediation of divalent metal ions in the binding of tetracycline to macromolecules. Nature (London) 191: 1156-1158, 1961 CrossrefMedlineGoogle Scholar6. CONRADSCHADE MS: Ascorbic acid chelates in iron absorption: a role for hydrochloric acid and bile. Gastroenterology 55:35-45, 1968 CrossrefMedlineGoogle Scholar7. YEHSKILS SM: Effect of tetracycline on intestinal absorption of various nutrients by the rat. Proc Soc Exp Biol Med 123:367-370, 1967 CrossrefGoogle Scholar8. GREENBERGERRUPPERTCUPPAGE NRF: Inhibition of intestinal iron transport induced by tetracycline. Gastroenterology 53:590-597, 1967 CrossrefMedlineGoogle Scholar9. GREENBERGERRUPPERTPERKINS NRR: Unpublished observations Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: NORTON J. GREENBERGER, M.D.Affiliations: Division of Gastroenterology Ohio State University College of Medicine Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIron Restriction to Clinical Isolates of Candida albicans by the Novel Chelator DIBI Inhibits Growth and Increases Sensitivity to Azoles In Vitro and In Vivo in a Murine Model of Experimental VaginitisThe transport of tetracyclines across the mouse ileum in vitro : the effect of cations and other agentsHemmung der Eisenabsorption beim Menschen durch TetracyclinTetracycline inhibits iron absorption in man 1 May 1971Volume 74, Issue 5Page: 792-793KeywordsAntibioticsAttentionIngestionMouthSulfatesTetracyclines ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...