tbuckley/cabot-search huggingface dataset:
Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis
Authors: Sonia Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu, Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier, Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer, Renato C. Monteiro, Pierre de la Grange, Richard Moreau
Journal: Journal of Hepatology (2013)
Serum Hyperviscosity in Sjögren's Syndrome
Authors: Donato Alarcón-Segovia, Eugenia Fishbein, John L. Abruzzo, Ralph Heimer
Journal: Annals of Internal Medicine (1974)

Two patients had Sjögren's syndrome and chronic polysynovitis that had caused neither deformity nor bony erosions. Both patients had increased serum viscosity, and one patient had the hyperviscosity syndrome. Increased serum viscosity correlated with the presence of intermediate complexes that seem to be formed by interactions between IgG antigen and IgG rheumatoid factor. Neither the occurrence of the hyperviscosity syndrome in Sjögren's syndrome nor the association of hyperviscosity with circulating serum IgG-IgG rheumatoid factor complexes has been previously reported.
The Growing Commercial Value of the Male Body: A Longitudinal Survey of Advertising in Women’s Magazines
Authors: Harrison G. Pope Jr., Roberto Olivardia, John J. Borowiecki III, Geoffrey H. Cohane
Journal: Psychotherapy and Psychosomatics (2001)

With the advances of feminism, men have gradually relinquished their once-exclusive 'masculine' roles as fighters and breadwinners. In response to this change, the male body may have gained in relative importance as one of the few surviving marks of masculinity. We hypothesized that these trends might be quantified by using a commercial measure such as advertising.We examined the proportion of exposed male and female bodies portrayed in advertisements between 1958 and 1998 in two leading American women's magazines.In both magazines, the proportion of undressed women in the advertisements has changed little over the last 40 years, whereas the proportion of undressed men has increased dramatically, especially since the early 1980s.Trends in commercial advertising offer tentative support for the hypothesis that the male body is increasing in importance as a mark of masculinity--at least as judged from the actions of advertisers seeking to influence women's attitudes.
Intermittent pneumatic compression to prevent venous thromboembolism in patients with high risk of bleeding hospitalized in intensive care units: the CIREA1 randomized trial
Authors: Philippe Vignon, Pierre-François Dequin, Anne Renault, Armelle Mathonnet, Nicolas Paleiron, Audrey Imbert, Delphine Chatellier, Valérie Gissot, Gwenaelle Lhéritier, Victor Aboyans, Gwenael Prat, Denis Garot, Thierry Boulain, Jean-Luc Diehl, Luc Bressollette, Aurélien Delluc, Karine Lacut
Journal: Intensive Care Medicine (2013)
THE LAW OF PERIODICITY IN INEBRIETY.
Authors: T.D. CROTHERS
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trauma and seronegative spondyloarthropathy: report of two more cases of peripheral arthritis precipitated by physical injury.
Authors: I Olivieri, G Gemignani, C Christou, G Pasero
Journal: Annals of the Rheumatic Diseases (1989)

Two more cases of B27 associated peripheral arthritis triggered by physical injury are reported. One patient developed arthritis after a minor insult and in the other Reiter9s syndrome occurred after the injury. Possibly, trauma causes release of self antigens from the injured joints.
Viruses and Water Quality
Authors: J. A. Bell
Journal: JAMA (1972)

There is a growing concern with the problem of possible viral pollution of water supplies in this country. From an epidemiological point of view, only the infectious hepatitis virus has been considered to be transmitted by water. Gross contamination of drinking water by sewage wastes was responsible for a major epidemic of infectious hepatitis in New Delhi (1955-1956), and resulted in 35,000 cases, 73 deaths, and a case rate of 2,000/100,000 in a single month. In the United States, the annual incidence of infectious hepatitis has remained at a level of 50,000 to 60,000 cases per year during most of the 1952 to 1970 period, while the total annual incidence of typhoid fever dropped continuously from approximately 2,000 cases in 1952 to only 346 cases in 1970. There has been one significant waterborne outbreak of infectious hepatitis during each of the last three years, including the Worcester, Mass, episode that
<i>Demodex</i>Folliculitis Mimicking Acute Graft-vs-Host Disease
Authors: Jonathan Cotliar, Olga Frankfurt
Journal: JAMA Dermatology (2013)

Acute graft-vs-host disease (GVHD) typically requires high-dose systemic steroids as first-line treatment. Like drug eruptions, viral exanthema, and toxic erythema of chemotherapy, Demodex folliculitis is a clinical mimicker of acute GVHD and requires nonimmunosuppressive therapy. This case of Demodex folliculitis mimicking acute GVHD highlights the need for skin biopsy in patients who have undergone a stem cell transplant with eruptions on the head and neck.A 46-year-old white woman with a history of Fms-like tyrosine kinase 3 acute myeloid leukemia presented to the dermatology clinic with a 5-day history of a nonpruritic eruption on her face and neck 28 days after undergoing a double umbilical cord blood hematopoietic stem cell transplant (HSCT). Findings from the skin biopsy demonstrated a deep dermal lymphocytic infiltrate adjacent to follicular units along with an abundance of Demodex mites noted within the hair follicles consistent with Demodex folliculitis. Oral ivermectin, 12 mg, was given, and the eruption cleared within 24 hours.To our knowledge, this is only the fifth reported case of Demodex folliculitis following HSCT, but the first ever reported to be successfully treated with oral ivermectin. Demodex folliculitis should be added to the differential diagnosis of skin eruptions that arise after HSCT.
Identifying who is at risk of drug-induced liver injury: Is human leukocyte antigen specificity the key?
Authors: Shivakumar Chitturi, Geoffrey C. Farrell
Journal: Hepatology (2011)

Lumiracoxib is a selective cyclooxygenase-2 inhibitor developed for the symptomatic treatment of osteoarthritis and acute pain. Concerns over hepatotoxicity have contributed to the withdrawal or nonapproval of lumiracoxib in most major drug markets worldwide. We performed a case-control genome-wide association study on 41 lumiracoxib-treated patients with liver injury (cases) and 176 matched lumiracoxib-treated patients without liver injury (controls). Several SNPs from the MHC class II region showed strong evidence of association (the top SNP was rs9270986 with P = 2.8 × 10−10. These findings were replicated in an independent set of 98 lumiracoxib-treated cases and 405 matched lumiracoxib-treated controls (top SNP rs3129900, P = 4.4 × 10−12. Fine mapping identified a strong association to a common HLA haplotype (HLA-DRB1*1501-HLA-DQB1*0602-HLA-DRB5*0101-HLA-DQA1*0102, most significant allele P = 6.8 × 10−25, allelic odds ratio = 5.0, 95% CI 3.6-7.0). These results offer the potential to improve the safety profile of lumiracoxib by identifying individuals at elevated risk for liver injury and excluding them from lumiracoxib treatment.
Perceived Inspiratory Difficulty during Inspiratory Threshold and Hyperinflationary Loadings
Authors: RONG CHANG CHEN, SHENG YAN
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Dynamic hyperinflation loads the inspiratory muscles by increasing end-expiratory lung volume (EELV) and imposing intrinsic positive end-expiratory pressure (PEEPi), the latter behaving as an inspiratory threshold load (ITL). The major purpose of this study was to describe the independent effects of the imposed ITL and changes in operating lung volume on the perception of inspiratory difficulty. In eight healthy subjects, independent increases in EELV and ITL were induced by continuous positive airway pressure (CPAP) and external ITL applications, respectively; increase in both EELV and PEEPi (thus the imposed ITL) was induced by application of positive end-expiratory pressure (PEEP). The perceived inspiratory difficulty increased significantly when either EELV or ITL was increased, and was always greater during combined increase in EELV and the imposed ITL (during PEEP) than when either factor was increased independently, suggesting that the imposed ITL and EELV each contribute independently to inspiratory difficulty. Inspiratory difficulty of each subject under all conditions was then fitted into a step-forward multiple regression model. The imposed ITL was a significant contributor to inspiratory difficulty in all subjects and was the first parameter to be selected in six of the eight subjects. When the results of all the subjects were pooled, the imposed ITL alone explained 40% of variations in inspiratory difficulty. Adding the change in end-inspiratory lung volume ( Δ EILV) to the model explained an additional 24% of variations in inspiratory difficulty. The coefficients (slopes) of the imposed ITL and Δ EILV were 0.21 ± 0.02 cm H2O− 1 and 0.051 ± 0.006 %IC− 1, respectively. It is concluded that under our experimental conditions, the imposed ITL is a better predictor for explaining the variability of the perceived inspiratory difficulty than the operating lung volume.
Trichloroethylene Exposure during Cardiac Valvuloseptal Morphogenesis Alters Cushion Formation and Cardiac Hemodynamics in the Avian Embryo
Authors: Victoria J. Drake, Stacy L. Koprowski, John Lough, Norman Hu, Susan M. Smith
Journal: Environmental Health Perspectives (2006)

It is controversial whether trichloroethylene (TCE) is a cardiac teratogen. We exposed chick embryos to 0, 0.4, 8, or 400 ppb TCE/egg during the period of cardiac valvuloseptal morphogenesis (2-3.3 days' incubation) . Embryo survival, valvuloseptal cellularity, and cardiac hemodynamics were evaluated at times thereafter. TCE at 8 and 400 ppb/egg reduced embryo survival to day 6.25 incubation by 40-50%. At day 4.25, increased proliferation and hypercellularity were observed within the atrioventricular and outflow tract primordia after 8 and 400 ppb TCE. Doppler ultrasound revealed that the dorsal aortic and atrioventricular blood flows were reduced by 23% and 30%, respectively, after exposure to 8 ppb TCE. Equimolar trichloroacetic acid (TCA) was more potent than TCE with respect to increasing mortality and causing valvuloseptal hypercellularity. These results independently confirm that TCE disrupts cardiac development of the chick embryo and identifies valvuloseptal development as a period of sensitivity. The hypercellular valvuloseptal profile is consistent with valvuloseptal heart defects associated with TCE exposure. This is the first report that TCA is a cardioteratogen for the chick and the first report that TCE exposure depresses cardiac function. Valvuloseptal hypercellularity may narrow the cardiac orifices, which reduces blood flow through the heart, thereby compromising cardiac output and contributing to increased mortality. The altered valvuloseptal formation and reduced hemodynamics seen here are consistent with such an outcome. Notably, these effects were observed at a TCE exposure (8 ppb) that is only slightly higher than the U.S. Environmental Protection Agency maximum containment level for drinking water (5 ppb) .
Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats
Authors: Tarun K. Gupta, Murat Toruner, Moon K. Chung, Roberto J. Groszmann
Journal: Hepatology (1998)

Increased intrahepatic resistance in cirrhotic livers is in part caused by increased vascular tone. Several morphological abnormalities have been described in the sinusoidal endothelial cells of cirrhotic livers, but the functional impact of these abnormalities on the intrahepatic vascular tone has not been studied. The aim of this study was to investigate the intrahepatic endothelial function and the role of nitric oxide (NO) with regard to vascular tone in cirrhotic livers. Isolated rat liver perfusions were performed in cirrhotic rats (induced by chronic carbon tetrachloride inhalation) and weight-matched normal controls. After preconstricting the intrahepatic microcirculation with methoxamine (10(-4) mol/L), response to cumulative doses of receptor-mediated endothelial agonist, acetylcholine (10(-7) mol/L-10(-5) mol/L), was obtained. In another series, response to the receptor-independent endothelial agonist, calcium ionophore A23187 (10(-7) mol/L and 3 x 10(-7) mol/L), was obtained in the absence and presence of Nomega-nitro-L-arginine (NNA) and indomethacin. In a third series of rats, nitrate and nitrite production was measured in the perfusate of perfused normal and cirrhotic livers. There was significantly less vasorelaxation in cirrhotic livers as compared with normal livers in response to acetylcholine and calcium ionophore A23187 (P < .0001). The impaired vasorelaxation was a result of a decrease in both NO-mediated and non-NO-mediated components of vasorelaxation. Cirrhotic livers from ascitic rats had significantly less vasorelaxation as compared with livers from nonascitic rats (P < .005). There was significantly less production of nitrates and nitrites in cirrhotic livers (P < .05). The liver microcirculation of cirrhotic livers is characterized by endothelial dysfunction that results in impaired release of endothelial relaxing factors including NO.
Pre- and Postoperative Rest and Exercise Hemodynamics in Children with Pulmonary Stenosis
Authors: FREDERIC M. STONE, F. BLANTON BESSINGER, RUSSELL V. LUCAS, JAMES H. MOLLER
Journal: Circulation (1974)

Twenty children with pulmonary valvular stenosis were studied by cardiac catheterization both at rest and during submaximal supine exercise, prior to and following pulmonary valvotomy. The resting and exercise states were comparable preoperatively and postoperatively since cardiac output, heart rate, A - V O 2 difference and oxygen consumption were similar. Evidence of improved cardiac function was found postoperatively. Both the rest and the exercise right ventricular end-diastolic pressure (RVEDP) decreased significantly following pulmonary valvotomy. Preoperatively, 12 of 20 patients showed an increase in RVEDP with exercise; in six of these there was a simultaneous fall in stroke index, indicating impaired myocardial function. No patient showed this response postoperatively. This indicates that although altered cardiac function can be demonstrated in some children with pulmonary valvular stenosis, it is reversible by pulmonary valvotomy. This is in contrast to studies in adults, and suggests that a factor in the natural history of pulmonary valvular stenosis is the impact of chronically elevated afterload on the right ventricle. Hemodynamic measurements made during exercise provide a useful means of assessing patients with pulmonary stenosis before and after pulmonary valvotomy.
P243Glucose metabolism and blood pressure control status in professional hypertension clinics in China
Authors: H Wang, N Sun, Y Huo
Journal: Cardiovascular Research (2014)

Objective: To investigate the glucose metabolism status, cardiovascular risk factors distribution and blood pressure control rate in patients who were diagnosed and treated in the professional hypertension clinics in China. Methods: A cross-sectional survey was conducted to 32004 patients in 127 professional hypertension clinics across the country. The questionnaire included the history of associated diseases and its treatment conditions. Physical examination and biochemical tests were also performed at the same time. Results: The mean blood pressure was 150.34/92.21mmHg in all the patients. 3424 patients (10.7%) had never taken any anti-hypertension medicine. Among patients treated with anti-hypertension drugs, 19818 cases received mono-therapy(69.3%) and 8762 cases received combination therapy(30.7%). The most frequently used drug was renin-angiotensin system inhibitors, followed by calcium-channel blockers. About 15.6% patients had taken fixed compound preparations. - The overall blood pressure control rate (<140/90 mmHg ) was 26.8%, which was 27.7%, 30.0%, 25.4% and 21.3% in patients complicated with coronary heart disease, diabetes mellitus, kidney diseases and cerebral stroke respectively. - About 70.3% hypertensive patients had abnormal glucose metabolism whose mean GHbA1c was 7.84% which was much higher than 7.0% , the target value defined by ADA, even among them, 20.2% had not taken any anti-diabetic drugs. - Low-risk and medium-risk patients accounted for 16%, 48.0% of high-risk and 36.0% of very high risk. About half of all patients had different target organ damages and about 49% of them had associated with clinical complications. Conclusions: Hypertension complicated with abnormal glucose metabolism was widespread, more target organ damages and clinical diseases exist in these patients, but less than 30% of them had reached the target blood pressure. Low proportion of the combination therapy was one of the reasons of low blood pressure control rate. This showed that the effective management of blood pressure is inevitable.
Hormone Replacement Therapy and Heart Disease Prevention
Authors: Diana B. Petitti
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of a laminar steady-state fluid-imposed wall shear stress on the binding, internalization, and degradation of low-density lipoproteins by cultured arterial endothelium.
Authors: E A Sprague, B L Steinbach, R M Nerem, C J Schwartz
Journal: Circulation (1987)

Fluid mechanical steady-state laminar wall shear stresses of 30 dyne/cm2 (high stress) and less than 1 dyne/cm2 (low stress) have been applied for varying times to confluent cultures of bovine aortic endothelial cells (BAECs) by means of two parallel plate channel flow chambers in series. BAEC cultures not exposed to shear or flow (no stress) were also studied. A shear stress of 30 dyne/cm2 resulted in cellular elongation and alignment, changes that were largely complete by 24 hr. In experiments in which BAECs were incubated with 125I-labeled low-density lipoprotein for 2 or 24 hr in the presence of shear stress levels, 125I-LDL internalization at 24 hr was increased (p less than .05) in response to high-stress conditions. This increased uptake of 125I-LDL was observed in BAECs prealigned for 24 hr under high stress and in BAECs undergoing alignment in the presence of circulating 125I-LDL. BAECs were also exposed to shear stress for 24 hr in the presence of a lipoprotein-deficient circulating medium to maximize LDL receptor expression. Receptor-mediated 125I-LDL internalization and degradation measured immediately after shear stress were both significantly enhanced (p less than .01) in BAECs exposed to high stress. Furthermore, 125I-LDL binding studies at 4 degrees C revealed a significant increase (p less than .01) in specific 125I-LDL binding to BAECs exposed to high stress relative to those exposed to low or no stress. Nonspecific 125I-LDL endocytosis was not influenced by shear stress levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Ingested Carbohydrates and Blood Glucose in Diabetics-Reply
Authors: JOHN M. Amatruda
Journal: JAMA (1985)

<h3>In Reply.—</h3> Ms Halford and Dr Weir address the important concept that not all forms of carbohydrate are absorbed equally. They further address the question that a 2.5-oz Hershey chocolate bar containing 39 g of sucrose might not produce the same glycemic response as 20 g of D-glucose. Unfortunately, the article that they quote to show the glycemic response to 25 g of carbohydrate taken as milk chocolate is not readily available. It is, therefore, very difficult to assess or comment on the results of that study. Obviously, the results would depend on the milk chocolate bars ingested, the patient population selected for testing, the insulin response of the patient population selected, and multiple other variables. In addition, we carefully pointed out several of the points alluded to by Ms Halford and Dr Weir. We state in our manuscript that the specific form of carbohydrate may be more important than