Chronic Fluoride Intoxication with Fluorotic Radiculomyelopathy
Authors: BERTRAM J. L. SAUERBRUNN
Journal: Annals of Internal Medicine (1965)

Case Studies1 December 1965Chronic Fluoride Intoxication with Fluorotic RadiculomyelopathyBERTRAM J. L. SAUERBRUNN, M.D., CHARLES M. RYAN, M.D., F.A.C.P., JAMES F. SHAW, M.D.BERTRAM J. L. SAUERBRUNN, M.D.Search for more papers by this author, CHARLES M. RYAN, M.D., F.A.C.P.Search for more papers by this author, JAMES F. SHAW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-1074 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAll cases of chronic fluoride intoxication with radiculomyelopathy have been previously reported from India (1, 2). This paper describes a patient with clinical, necropsy, and toxicologic findings of this disorder, whose problem is of special interest because he lived in an area where cases of advanced fluorosis would not be expected.CASE REPORTA 64-year-old white male was admitted to the Veterans Administration Hospital, McKinney, Tex., on May 11, 1962, because of severe respiratory distress and semicoma. He had been a complete invalid in a nursing home for a year.At his first hospitalization at McKinney in 1950 he complained...References1. SINGHJOLLYBANSALMATHUR ASSBCCC: Endemic fluorosis. Medicine 42: 229, 1963. CrossrefMedlineGoogle Scholar2. SIDDIQUI AH: Fluorosis in Nalgonda District, Hyderbad-Deccan. Brit. Med. J. 2: 1408, 1955. CrossrefMedlineGoogle Scholar3. FRERE FJ: A microdiffusion method for determination of fluorides. Microchem. J. 6: 167, 1962. CrossrefGoogle Scholar4. CALENOFF L: Osteosclerosis from intentional ingestion of hydrofluoric acid. Amer. J. Roentgen. 87: 1112, 1962. Google Scholar5. LARGENT EJ: Fluorosis. The Health Aspects of Fluorine Compounds. Ohio State University Press, Columbus, 1961, p. 23, 54. Google Scholar6. LARGENTBOVARDHEYROTH EJPGFF: Roentgenographic changes and urinary fluoride excretion among workmen engaged in the manufacture of inorganic fluorides. Amer. J. Roentgen. 65: 42, 1951. Google Scholar7. LEONESTEVENSONHILBISHSOSMAN NCCATFMC: A roentgenologic study of a human population exposed to high fluoride domestic water: a 10-year study. Amer. J. Roentgen. 74: 874, 1955. Google Scholar8. LINSMANMCMURRAY JFCA: Fluoride osteosclerosis from drinking water. Radiology 40: 474, 1943. CrossrefGoogle Scholar9. STEVENSONWATSON CAAR: Fluoride osteosclerosis. Amer. J. Roentgen. 78: 13, 1957. Google Scholar10. SINGHDASSHEYREHJOLLY ARSSSS: Skeletal changes in endemic fluorosis. J. Bone Joint Surg. 44B: 806, 1962. CrossrefGoogle Scholar11. AZARNUCHOBAYYUKBAYYUK HACKSIWB: Skeletal sclerosis due to chronic fluoride intoxication: cases from an endemic area of fluorosis in the region of the Persian Gulf. Ann. Intern. Med. 55: 193, 1961. LinkGoogle Scholar12. SINGHJOLLY ASS: Endemic fluorosis. Quart. J. Med. 30: 357, 1961. MedlineGoogle Scholar13. ZIPKINMCCLURELEONELEE IFJNCWA: Fluoride deposition in human bones after prolonged ingestion of fluoride in drinking water. Public Health Rep. 73: 732, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: McKinney and Dallas, TexasFrom the Medical and Radiology Services, Veterans Administration Hospital, McKinney, Tex., and the University of Texas Southwestern Medical School, Dallas, Tex.Requests for reprints should be addressed to Bertram J. L. Sauerbrunn, M.D., Hematology Section, Veterans Administration Hospital, 50 Irving St., N.W., Washington, D. C. 20422. 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