Vaccine Prophylaxis for Pseudomonas Infections
Authors: KEHL MARKLEY
Journal: Annals of Internal Medicine (1971)

Editorial Notes1 January 1971Vaccine Prophylaxis for Pseudomonas InfectionsKEHL MARKLEY, M.D.KEHL MARKLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-1-140 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of an effective pseudomonas vaccine for the prophylaxis of fatal pseudomonas infection in burned patients has been reported by Fisher and his co-workers (1-3). This event is the culmination of a number of various investigations.In spite of the fact that burned animals are more susceptible toPseudomonas aeruginosainfections than normal animals (4, 5), their antibody production against chemical antigens (6-8), as well as particulate antigens such as sheep erythrocytes (9) and bacteria (10), rises to the same levels as that observed in normal animals. For this reason active immunization seemed feasible. Specific (5, 11) as well...References1. FISHERDEVLINGNABSIK MHF: New immunotype schema for Pseudomonas aeruginosa based on protective antigens. J Bact 98:835-836, 1969 CrossrefMedlineGoogle Scholar2. ALEXANDERFISHERMACMILLAN JMB: Prevention of invasive Pseudomonas infection in burns with a new vaccine. Arch Surg (Chicago) 99:249-256, 1969 CrossrefMedlineGoogle Scholar3. ALEXANDERFISHER JM: Immunological determinants of Pseudomonas infections of man accompanying severe burn injury. J Trauma 10:565-574, 1970 CrossrefMedlineGoogle Scholar4. ROSENTHALMILLICANRUST SRJ: A factor in human gamma globulin preparations active against Pseudomonas aeruginosa infections. Proc Soc Exp Biol Med 94: 214-217, 1957 CrossrefMedlineGoogle Scholar5. MILLICANEVANSMARKLEY RGK: Susceptibility of burned mice to Pseudomonas aeruginosa and protection by vaccination. Ann Surg 163:603-610, 1966 CrossrefMedlineGoogle Scholar6. MALTCOPE RO: Antibody production after certain forms of trauma. Surgery 39:959-969, 1956 MedlineGoogle Scholar7. MAGOVERNHARRISON GC: The effect of thermal trauma on antibody formation in rabbits. Amer Surg 23:257-263, 1957 MedlineGoogle Scholar8. ALEXANDER J: Immunologic phenomena in burn injuries. JAMA 199:257-260, 1967 CrossrefMedlineGoogle Scholar9. MARKLEYSMALLMANEVANS KEG: Antibody production in mice after thermal and tourniquet trauma. Surgery 61: 896-903, 1967 MedlineGoogle Scholar10. FOXLOWBURG JE: Immunity to Pseudomonas pyocyanea in man. J Path Bact 65:519-531, 1953 CrossrefMedlineGoogle Scholar11. NANCEHINESFULTON FJR: Treatment of experimental burn wound sepsis by postburn immunization with polyvalent Pseudomonas antigen. Surgery 68:248-253, 1970 MedlineGoogle Scholar12. MARKLEYSMALLMAN KE: Protection by vaccination against Pseudomonas infection after thermal injury. J Bact 96:867-874, 1968 CrossrefMedlineGoogle Scholar13. FELLERPIERSON IC: Pseudomonas vaccine and hyperimmune plasma for burned patients. Arch Surg (Chicago) 97:225-229, 1968 CrossrefMedlineGoogle Scholar14. FREIREICHLEVINWHANG ERJ: The function and fate of transfused leukocytes from donors with chronic myelocytic leukemia in leukopenic patients: Ann NY Acad Sci 113:1081-1089, 1964 CrossrefMedlineGoogle Scholar15. MARKLEYSMALLMAN KE: Protection of burned mice challenged with Pseudomonas by peritoneal exudate cells. J Reticuloendothel Soc 6:448-456, 1969 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Laboratory of Biochemical Pharmacology National Institute of Arthritis and Metabolic Diseases National Institutes of Health Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPseudomonas bacteremiaUse of a Pseudomonas aeruginosa vaccine in patients with acute leukemia and cystic fibrosisPseudomonas pneumoniaCurrent and Future Vaccines for the Prevention of Bacterial Diseases 1 January 1971Volume 74, Issue 1Page: 140-140KeywordsAntibody responseAntigensBacteriaParticulatesProphylaxisPseudomonasPseudomonas infectionsVaccination and immunizationVaccines Issue Published: 1 January 1971 PDF downloadLoading ...