tbuckley/cabot-search huggingface dataset:
An unsaturated fat diet prevents the increased angiotensin II vascular responses in renal artery stenosis
Authors: G. R Norton, I. E Katzeff, A. J Woodiwiss, C. Rosendorff
Journal: Cardiovascular Research (1992)

The aim was to characterise angiotensin II constrictor responses in two kidney, one clip (2K1C) renal hypertensive rats fed a diet with a high unsaturated fatty acid content.Two diets with the same total fat (37% by energy; 17% by weight) but different unsaturated fat contents were fed to rats for a three month period. Thirty four Sprague Dawley rats were used per diet group. After one month on the diets, a group of 19 rats in each diet group was operated upon to induce 2K1C hypertension. A separate group of 15 rats within each diet group received sham operations. Systolic blood pressure was measured weekly from prior to surgery to the end of the three month feeding period. At three months, angiotensin II constrictor responses were evaluated in the isolated kidney vascular preparation and in intact anaesthetised rats fed the different diets. Phenylephrine constrictor responses were also evaluated in intact anaesthetised rats in order to exclude structural vascular changes accounting for differences in angiotensin II constrictor responses.The diet high in unsaturated fats prevented the development of hypertension in 2K1C rats [systolic pressure 134(7) mm Hg at eight weeks] compared to their own preoperative blood pressures [124(3) mm Hg], and to the 2K1C rats fed the control diet [163(7) mm Hg at eight weeks]. The diet high in unsaturated fats did not alter blood pressures in sham operated rats. In isolated perfused kidneys and in anaesthetised 2K1C rats fed the control diet, angiotensin II caused a greater vascular response compared to the sham operated groups. The unsaturated fat diet prevented this effect. No differences were found in blood pressure responses to phenylephrine.These data suggest that the antihypertensive effect of a high unsaturated fat diet may in part be due to a depressed responsiveness of vascular smooth muscle to endogenous angiotensin II. The effect is likely to be due to modulation of angiotensin II vascular responses by local vascular changes that cannot be accounted for by structural vascular differences.
Bounty acts responsibly
Authors: C. Gooderham
Journal: BMJ (2013)

Although most of McCartney’s article was fair,1 I would like to affirm that Bounty is proud to be a responsible commercial force for good.

For more than 50 years, Bounty has offered services to mothers and healthcare professionals on the basis of choice, giving value to the NHS and health information to mothers.

Ninety nine per cent of …
Idiopathic Pulmonary Fibrosis
Authors: TALMADGE E. KING, MARVIN I. SCHWARZ, KEVIN BROWN, JANET A. TOOZE, THOMAS V. COLBY, JAMES A. WALDRON, ANDREW FLINT, WILLIAM THURLBECK, REUBEN M. CHERNIACK
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

It is hypothesized that the extent and severity of fibrosis and cellularity found on lung biopsy determine the prognosis and response to therapy in idiopathic pulmonary fibrosis (IPF). The objective of this study was to determine which histopathologic features predict survival in IPF. We prospectively studied 87 patients with usual interstitial pneumonia (UIP) confirmed by surgical lung biopsy. Four pathologists independently graded the extent and severity of specific histopathologic features. We used Cox proportional-hazards models to assess the effect of histopathologic patterns on patients' survival. The effects of age, sex, and smoking were also included in the analysis. Sixty-three patients died during the 17-yr study period. Survival was longer in subjects with lesser degrees of granulation/connective tissue deposition (fibroblastic foci). The degree of alveolar space cellularity, alveolar wall fibrosis, and cellularity did not affect survival. A history of cigarette smoking, the level of dyspnea, and the degree of lung stiffness at presentation were also shown to be independent factors predicting survival. The extent of fibroblastic foci present on lung biopsy predicts survival in IPF. These findings support the hypothesis that the critical pathway to end-stage fibrosis is not “alveolitis” but rather the ongoing epithelial damage and repair process associated with persistent fibroblastic proliferation. Controlling these processes, rather than stopping inflammation, appears most important in preventing progressive disease and the fatal outcome common in IPF.
TCT-70 Ability of the bioresorbable vascular scaffold to re-cap the underlying plaque. A serial optical coherence tomography study
Authors: Christos Bourantas, Shimpei Nakatani, Yao-Jun Zhang, Vasim Farooq, Roberto Diletti, Cécile Dorange, Richard Rapoza, Alexander Sheehy, Yoshinobu Onuma, Hector M. Garcia-Garcia, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2013)
Nouveaux procédés en psychothérapie analytique
Authors: N.N. Dracoulidès
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 Nouveaux procédés en psychothérapie analytique Subject Area: Psychiatry and Psychology N.N. Dracoulidès N.N. Dracoulidès Athènes Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 143–148. https://doi.org/10.1159/000287115 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation N.N. Dracoulidès; Nouveaux procédés en psychothérapie analytique. Psychother Psychosom 31 December 1978; 29 (1-4): 143–148. https://doi.org/10.1159/000287115 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Perioperative echocardiographic evaluation of cardiovascular function: assessment of changing hemodynamic state.
Authors: R E Kavey, E Krongrad, W M Gersony
Journal: Circulation (1980)

To evaluate echocardiographic assessment of ventricular function in a changing hemodynamic situation, 20 infants and children undergoing open heart surgery were examined preoperatively and 1,4 and 24 hours postoperatively by this technique. Clinical evaluation and measurements of cardiac output were obtained simultaneously with each echocardiogram. On the basis of their clinical course and cardiac output, the patients were divided into two groups: group 1 - cardiac index > 2.3 1/min/m2 without inotropic support (n = 9); and group 2 - cardiac index less than or equal to 2.3 1/min/m2 and/or need for inotropic support (n = 11). Of the echocardiographic measurements obtained, the left ventricular systolic time interval ratio (left ventricular preejection period/left ventricular ejection time ([LVPEP/LVET] correlated significantly with the clinical course, separating the two groups of patients completely at each determination. The aortic root velocity (AoV), a new index defined as the anterior excursion (in degrees) of the aortic root from the horizontal plane with systole, also correlated with the clinical course, although this was not statistically significant. Serial change in LVPEP/LVET and AoV crrrelated with changes in clinical status and cardiac output for individual patients. Using a formula based on the opening slope of the mitral valve, echocardiographic estimations of cardiac output correlated well with those determined by dye dilution. The results indicate that selected echocardiographic indexes can be used for serial assessment of cardiac performance in patients with a changing hemodynamic state.
Mendel--both ignored and forgotten
Authors: M. Keynes
Journal: Journal of the Royal Society of Medicine (2002)

Stevens' cure for tuberculosis I was fascinated by Dr Newsom's account of Stevens' cure (September 2002 JRSM 1 ).In 1927 my father was apparently close to death in Talgarth TB sanatorium, South Wales, with severe bilateral lung disease and multiple haemoptyses.He was considered too ill for the thoracoplasty operation fashionable at the time.His father, himself dying of TB, had advised him on his deathbed to try Stevens' cure and at this stage of his illness he did.His recovery started from that date.He never had another haemoptysis and within 3-4 years was able to obtain life insurance and marry.The medical examiner was said to have flung down his stethoscope in amazement, declaring 'no sign of disease at all'.My father continued to take the umckaloabo root on and off for years but never had another attack.The distinctive pungent odour of what seemed to be an infusion would often fill the house and signal that Dad was not feeling too good for some reason.He worked as a chemistry teacher till he was 65 with never a day 'off sick' and died of heart failure at 77.When I went to Oxford to read medicine in 1958 I was found, to my surprise, to be Mantoux-test negative.My father, who possessed a lot of newspaper articles and one of the books on Stevens' cure, thought the BMA had been very unfair to Stevens (a non-medic) and very unscientific in their approach to a much needed avenue of possible TB research.Perhaps today, with the widespread resistance to TB drugs, the root should be properly evaluated.
Endothelin-1 Is a Critical Mediator of Myogenic Tone in Tumor Arterioles
Authors: Pierre Sonveaux, Chantal Dessy, Philippe Martinive, Xavier Havaux, Bénédicte F. Jordan, Bernard Gallez, Vincent Grégoire, Jean-Luc Balligand, Olivier Feron
Journal: Cancer Research (2004)

Abstract Although derived from the host tissue, the tumor vasculature is under the influence of the tumor microenvironment and needs to adapt to the resistance to blood flow inherent to the dynamics of tumor growth. Such vascular remodeling can offer selective targets to pharmacologically modulate tumor perfusion and thereby improve the efficacy of conventional anticancer treatments. Radiotherapy and chemotherapy can, indeed, take advantage of a better tumor oxygenation and drug delivery, respectively, both partly dependent on the tumor blood supply. Here, we showed that isolated tumor arterioles mounted in a pressure myograph have the ability, contrary to size-matched healthy arterioles, to contract in response to a transluminal pressure increase. This myogenic tone was exquisitely dependent on the endothelin-1 pathway because it was completely abolished by the selective endothelin receptor A (ETA) antagonist BQ123. This selectivity was additionally supported by the large increase in endothelin-1 abundance in tumors and the higher density of the ETA receptors in tumor vessels. We also documented by using laser Doppler microprobes and imaging that administration of the ETA antagonist led to a significant increase in tumor blood flow, whereas the perfusion in control healthy tissue was not altered. Finally, we provided evidence that acute administration of the ETA antagonist could significantly stimulate tumor oxygenation, as determined by electron paramagnetic resonance oximetry, and increase the efficacy of low-dose, clinically relevant fractionated radiotherapy. Thus, blocking the tumor-selective increase in the vascular endothelin-1/ETA pathway led us to unravel an important reserve of vasorelaxation that can be exploited to selectively increase tumor response to radiotherapy.
A novel method for estimating a normalized value of myocardial blood volume by compensating for the attenuation of incident ultrasound in contrast echocardiography
Authors: Satoshi Yamada, Kaoru Komuro, Taisei Mikami, Keiko Nishihara, Hisao Onozuka, Akira Kitabatake
Journal: Journal of the American College of Cardiology (2002)
Flow Acceleration Time and Ratio of Acceleration Time to Ejection Time for Prosthetic Aortic Valve Function
Authors: Sagit Ben Zekry, Robert M. Saad, Mehmet Özkan, Maie S. Al Shahid, Mauro Pepi, Manuela Muratori, Jiaqiong Xu, Stephen H. Little, William A. Zoghbi
Journal: JACC. Cardiovascular imaging (2011)
Prevalence and Associations of Abdominal Aortic Aneurysm Detected through Screening
Authors: Frank A. Lederle, Gary R. Johnson, Samuel E. Wilson, Edmund P. Chute, Fred N. Littooy, Dennis Bandyk, William C. Krupski, Gary W. Barone, Charles W. Acher, David J. Ballard
Journal: Annals of Internal Medicine (1997)

Independent risk factors for abdominal aortic aneurysm (AAA) have not been clearly defined in multivariable analyses of large patient populations.To identify factors that are independently associated with AAA and to determine the prevalence of previously unrecognized AAA in defined demographic and risk groups.Cross-sectional screening study.15 Department of Veterans Affairs medical centers.73451 veterans who were 50 to 79 years of age and had no history of AAA.The results of ultrasonographic screening for AAA and a prescreening questionnaire were analyzed using multiple logistic regression.An AAA of 4.0 cm or larger was detected in 1031 participants (1.4%). Smoking was the risk factor most strongly associated with AAA; the odds ratio (OR) for AAAs of 4.0 cm or larger compared with normal aortas (infrarenal aortic diameter < 3.0 cm) was 5.57 (95% CI, 4.24 to 7.31). The association between smoking and AAA increased significantly with the number of years of smoking and decreased significantly with the number of years after quitting smoking. The excess prevalence associated with smoking accounted for 78% of all AAAs that were 4.0 cm or larger in the study sample. Female sex (OR, 0.22 [CI, 0.07 to 0.68]), black race (OR, 0.49 [CI, 0.35 to 0.69]), and presence of diabetes (OR, 0.54 [CI, 0.44 to 0.65]) were negatively associated with AAA. A family history of AAA was positively associated with AAA (OR, 1.95 [CI, 1.56 to 2.43]) but was reported by only 5.1% of participants. Other independently associated factors included age, height, coronary artery disease, any atherosclerosis, high cholesterol levels, and hypertension.Abdominal aortic aneurysm is associated with multiple factors. Smoking was the risk factor most strongly associated with AAA and may be responsible for most clinically important cases of previously undiagnosed AAA.
Phase 2/3 Study of the Novel Vaccine Amb a 1 Immunostimulatory Oligodeoxyribonucleotide Conjugate AIC in Ragweed-Allergic Adults
Authors: W. Busse, G. Gross, P. Korenblat, N. Nayak, M. Tarpay, D. Levitt
Journal: Journal of Allergy and Clinical Immunology (2006)
The past incidence of hepatitis C virus infection: Implications for the future burden of chronic liver disease in the United States
Authors: Gregory L. Armstrong, Miriam J. Alter, Geraldine M. McQuillan, Harold S. Margolis
Journal: Hepatology (2000)

Because chronic liver disease may develop many years after acute hepatitis C virus (HCV) infection, the past incidence of acute infections is a major determinant of the future burden of HCV-associated complications. We estimated past incidence of acute HCV infection using national seroprevalence data and relative age-specific incidence data from a sentinel counties surveillance system. Projections of the future prevalence of HCV-infected patients were derived from models that included an 85% drop in HCV infection incidence as observed for reported cases in the early 1990s. The models showed a large increase in the incidence of HCV infections from the late 1960s to the early 1980s. The degree of increase was dependent on the assumed rate of antibody loss; a model with 2.5% annual antibody loss showed annual incidence increasing from 45,000 infections (95% confidence interval [95% CI]: 0-110,000) in the early 1960s to 380,000 infections (95% CI: 250,000 to 500,000) in the 1980s. Projections showed that although the prevalence of HCV infection may be declining currently because of the decline in incidence in the 1990s, the number of persons infected for ≥20 years could increase substantially before peaking in 2015. If the incidence of new HCV infections does not increase in the future, persons born between 1940 and 1965 will be at highest lifetime risk of acquiring the infection.
Auxiliary Liver Transplantation: A Negative Viewpoint
Authors: Abraham A. Shaked, Ronald W. Busuttil
Journal: Hepatology (1990)

Auxiliary heterotopic liver transplantation is theoretically attractive because it leaves the recipient's liver in place. The surgical trauma of hepatectomy is avoided, and failure of the graft does not necessarily lead to the death of the patient or a second, emergency transplantation. Another advantage is that matching the body sizes of the donor and the recipient is not mandatory, which increases the number of possible donors. However, previous clinical results of auxiliary liver transplantation have been poor. We performed auxiliary partial liver transplantation in six consecutive patients with end–stage chronic liver disease who were not accepted for orthotopic liver transplantation because they had massive ascites, deficient clotting function, cachexia, or poor pulmonary reserve. The donor liver was transplanted to the right subhepatic region after removal of segments II and III, and it was provided with portal and arterial blood. There were no major changes in hemodynamic measurements during surgery. The mean hospital stay after transplantation was 22.7 days (range, 14 to 29). After a mean follow–up period of 14 months (range, 5 to 23), all patients were alive, with good graft function as demonstrated by scintigraphy, Doppler ultrasonography, and synthesis of clotting factors. From these observations we conclude that auxiliary partial liver transplantation is an attractive alternative to orthotopic liver transplantation in high–risk patients. Its role in other patients who need liver transplants remains to be defined.
Polymyalgia rheumatica and primary biliary cirrhosis.
Authors: A K Clarke, E Hamilton, R Williams
Journal: BMJ (1979)

graft tissue, skin, to an abnormal culture atmosphere (45 ,' CO2 in air) for various periods (7-48 h).Normally-cultured skin grafts caused no lymphoid malignancy.Immunogenicity of exposed grafts as a result of modification of cell-surface proteins and production of "altered self" structures may be a factor in the subsequent appearance of lymphoma in these autologous hosts.In the animal models described above, malignant lymphoma develops as a late sequela of transplantations in the absence of exogenous immunosuppressants; chronic antigenic stimulation appears to be a possible common factor.Significantly, only lymphoid neoplasms developed despite the grafting of four different tissues-lymph node, mammary gland, skin, and bone marrow.Bone marrow is the only tissue that did not induce lymphoma in its recipients even following exposure to an unphysiological environment.This raises the question whether the T lymphocytes in the graft tissues are involved in the malignant processes in these animal models.
Patterns of dermatology referrals in a general hospital
Authors: N. HARDWICK, NORMA SAXE
Journal: British Journal of Dermatology (1986)

A survey of 500 patients hospitalized in non-dermatology wards and referred for dermatological opinion is reported. In approximately 50%, the skin lesions were related to the presenting illness; in 36.6% of these patients the skin condition contributed substantially to the diagnosis of the systemic disease. This study emphasizes the considerable interface between cutaneous and systemic disease and the need for close co-operation between medical and dermatology departments. The implications for postgraduate education are highlighted, since such patients are infrequently seen in a dermatology out-patient setting.
Clinical Significance and Pathogenesis of Osteoporosis
Authors: B. E. C. Nordin
Journal: BMJ (1971)

The development of osteoporosis with advancing age in man is a widespread if not a universal phenomenon. The average loss between youth and old age amounts to about 15% of the skeleton but involves a much larger proportion of trabecular than of cortical bone.THE PRINCIPAL CLINICAL MANIFESTATION OF OSTEOPOROSIS IS FRACTURE, AND THREE OSTEOPOROTIC FRACTURE SYNDROMES CAN BE DEFINED: the lower forearm fracture, which predominantly affects women between the ages of 50 and 65; the fracture of the proximal femur, which affects both sexes over the age of 70; and the relatively rare vertebral crush fracture syndrome, which may present at any age but is most common in elderly women.The lower forearm fracture rate is inversely related to the mean normal lower forearm x-ray "density" of the wrist, which falls by about 30% in the 15 years following the menopause. This process, which is associated with corresponding trabecular bone loss elsewhere in the skeleton, is associated with a corresponding rise in the fasting urinary calcium excretion. Some degree of negative calcium balance, and consequent bone resorption, probably occurs in everyone during the later part of the night because calcium absorption is completed within about three to five hours of a meal. In postmenopausal women, however, the sensitivity of the bone to parathyroid hormone appears to be increased, and their nocturnal negative calcium balance therefore comes to exceed the positive balance which can be achieved during the waking hours.Femoral neck fractures in old people reflect the further progression of osteoporosis with advancing age since the fracture rate is inversely correlated with the mean thickness of the metacarpal cortex in the normal population. This progressive osteoporosis is associated with and could well result from a steady decline in calcium absorption which is at least partially attributable to vitamin-D deficiency and reversible on vitamin-D treatment.The vertebral crush fracture syndrome represents a severe degree of spinal osteoporosis which may be associated with relatively normal peripheral bones. It probably results from an accelerated negative calcium balance which mobilizes trabecular bone preferentially. Some of the factors which may contribute to this accelerated negative balance have been identified and include a reduced rate of bone turnover, impaired calcium absorption, and low oestrogen activity as judged by vaginal smears, but there may well be others as yet unidentified.