tbuckley/cabot-search huggingface dataset:
THE TREATMENT OF FUNCTIONAL UTERINE HEMORRHAGE
Authors: EMIL NOVAK
Journal: JAMA (1926)

In the great majority of cases of uterine hemorrhage, the indication for treatment is perfectly clear. A definite anatomic lesion can be demonstrated in one of the pelvic organs, and the removal of such a lesion is the sine qua non for the cure of the abnormal bleeding. For example, the most common of all causes of persistent uterine hemorrhage is incomplete miscarriage, and the spontaneous or operative removal of the retained gestation products is followed by a cessation of the bleeding. In the same way, bleeding due to pelvic neoplasm or to pelvic inflammatory disease necessitates removal of the lesion.  In a much smaller but still not inconsiderable group of cases, however, uterine bleeding may be observed in the entire absence of any demonstrable gross lesions of the pelvic organs. Indeed, extremely profuse hemorrhage may occasionally be observed in children at or near the age of puberty. Far more
DRUG ERUPTION DUE TO QUININE: RECURRENCE FOLLOWING USE OF CONTRACEPTIVE
Authors: William K. Ford
Journal: JAMA (1934)

E. W. D., a man, aged 26, consulted me, Nov. 16, 1933, because of a vesicular dermatitis accompanied by intense itching of the scalp, face and neck of thirty-six hours' duration. The eruption began within twenty-four hours after two applications of Kreml hair tonic and consisted of tense, acuminate, split pea sized vesicles filled with a clear to straw colored fluid. There was edema of the scalp and eyes. November 17 his face became swollen and he had nausea, abdominal distress and loose stools.  The patient refused to have a patch test of the hair tonic but agreed to patch tests of the various ingredients. The manufacturer supplied a list of the ingredients and the patch tests were applied to the inner surface of the right arm. The patch containing 39A alcohol (18 Gm. of cinchonidine sulphate to 1 gallon of isopropyl alcohol) gave a definite papulovesicular reaction on an
The Influence of Mammaplasty in Axillary Lymphatic Drainage Patterns and Sentinel Lymph Node Detection.
Authors: C. Soler, C. Bouteille, H. Mignotte, A. Steiner, E. Gremillet, B. Geissler
Journal: Cancer Research (2009)

Abstract Introduction: Controlateral mammaplasty is often necessary during the procedure of breast reconstruction after mastectomy.However the impact of this kind of surgery on axillary lymphatic drainage and sentinel node (SN) detection remains controversial. The American Society of Clinical Oncology (ASCO) as published a guideline in 2005 and recommended that SN biopsy should not be performed in patients with previous mammplasty or axillary surgery.However, because of insufficient evidence and lack of scientific studies, mammaplasty cannot be considered as an absolute contraindication for SN biopsy procedure. Therefore, the same panellists of the ASCO guideline suggested that a preliminary lymphoscintigraphy (LSG) could be done when considering a SN biopsy in patients with previous mammaplasty, with the objective of verifying the integrity of the mammary gland and axillary nodes.The aim of our study was to evaluate the lymphatic patterns and SN detection rates after mammaplasty by using lymphoSPECT-CT (LS).Methods: ten patients who underwent mammaplasty were evaluated by LSG immediately after intradermal periareolar injections of 99mTc -labelled sulphur colloid (NanoCIS*) at two time points: before mammaplasty (Pre-LS) and between 40 to 60 days after mammaplasty (Post- LS).Results: all breasts drained primarily to the axillary SN. The binomial test did not show statistical difference in lymphatic drainage patterns between Pre-LSG and Post-LSG.The average number of hot SN was 1.28 in Pre-LS, 1.14 in Post-LS.The localisation of hot SN was evaluated by:- antero-posterior distance was estimated in centimeter from SN region to dorsal vertebrae spine center-SN's coronal position was compared to grill rib.The preservation of axillary lymphatic drainage after mammaplasty was allowed for SN detection in all studied breasts and the localisation of the sentinel node was the same after surgery than before.Conclusion: after evaluating the impact of the previous mammaplasty surgery on the accuracy of SLN biopsy, we observed that this kind of surgery did not significantly affects the accuracy of lymphatic mapping and that it may be possible to propose sentinel node biopsy after mammaplasty. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 1028.
Effect of Variable Stiffness Colonoscopes on Cecal Intubation Times for Routine Colonoscopy by an Experienced Examiner in Sedated Patients
Authors: D. K. Rex
Journal: Endoscopy (2001)

Background and Study Aims: Variable-stiffness colonoscopes allow passage of the rectosigmoid colon in a flexible mode, followed by stiffening to prevent looping. This feature might allow faster cecal intubation.
Naltrexone for the Management of Alcohol Dependence
Authors: Raymond F. Anton
Journal: New England Journal of Medicine (2008)

A 44-year-old businessman presents with clinical evidence of alcohol dependence and acknowledges excessive drinking. The use of naltrexone is recommended. Naltrexone is an opioid-blocking agent that inhibits reward signaling in the brain and reduces alcohol craving. Hepatotoxicity has been reported with naltrexone. This drug should not be used in patients who are physically dependent on opiates.
INCREASED PERICARDIAL FAT ACCUMULATION IS ASSOCIATED WITH INCREASED INTRAMYOCARDIAL LIPID CONTENT AND DURATION OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY EXPOSURE IN PATIENTS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS
Authors: Damini Dey, Mariana Diaz Zamudio, Troy LaBounty, Michael Nelson, Zhaoyang Fan, Lidia Szczepaniak, Pei Chin Hsieh, Ronak Rajani, Daniel Berman, Debiao Li, W. David Hardy, Anthony H. Conte
Journal: Journal of the American College of Cardiology (2015)
Endoscopic submucosal dissection for colorectal tumors: technical difficulties and rate of perforation
Authors: N. Yoshida, N. Wakabayashi, K. Kanemasa, Y. Sumida, D. Hasegawa, K. Inoue, Y. Morimoto, A. Kashiwa, H. Konishi, N. Yagi, Y. Naito, A. Yanagisawa, T. Yoshikawa
Journal: Endoscopy (2009)

Endoscopic submucosal dissection (ESD) for colorectal tumors is not generally recommended because of the technical difficulties and complications, including perforation. These aspects of ESD are thoroughly analyzed in our retrospective study.We studied 105 colorectal tumors, from 100 patients, that were treated by ESD at the Kyoto Prefectural University of Medicine or Nara City Hospital between 2005 and 2008. We analyzed tumor size, operation time, rate of en bloc resection, and complications. In addition, we thoroughly investigated the cases of perforation.The average tumor size was 30.4 mm; average operation time, 102 min; and rate of en bloc resection, 88.5 %. Perforation occurred in 10.4 % of the ESD procedures. Of the 11 perforations, 8 were detected during ESD and treated by clip closure during endoscopy, while 3 were evident only on subsequent routine computed tomography (CT); these were also managed conservatively. A case of postoperative hemorrhage was also observed.ESD effectively achieved a high rate of en bloc resection. However, the perforation rate was substantial; hence, improvement in the ESD method is required. The outcomes of ESD, especially for early colorectal malignancies, need to be assessed further.
Endoscopic Treatment of Primary Vesicoureteral Reflux
Authors: David A. Diamond, Tej K. Mattoo
Journal: New England Journal of Medicine (2012)

A 7-year-old girl with persistent, moderately severe vesicoureteral reflux has recurrent urinary tract infections while receiving prophylactic antibiotic therapy. Endoscopic correction of vesicoureteral reflux is recommended. The technique is described.
Bad medicine: medicated minors
Authors: Des Spence
Journal: BMJ (2010)

We live in a society obsessed with protecting children. From the time of conception we offer strict advice to avoid alcohol, cigarettes, and drugs for fear of damaging the child’s development. Childhood is a period of chaotic, experimental, irresponsible, challenging, and formative thinking. And despite my years I am still captive to the emotions of my misfit childhood. I would not trade one moment of the misery and happiness of that time, for it is a mental sanctuary from the pressure cooker of adult life.

But nature’s …
The Bipolar Disorder Phenome Database: A Resource for Genetic Studies
Authors: James B. Potash, Jennifer Toolan, Jo Steele, Erin B. Miller, Justin Pearl, Peter P. Zandi, Thomas G. Schulze, Layla Kassem, Sylvia G. Simpson, Victor Lopez, Dean F. MacKinnon, Francis J. McMahon
Journal: American Journal of Psychiatry (2007)

Objective: The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies. Method: Participants were ascertained for two bipolar disorder genetic linkage studies: the University of Chicago, Johns Hopkins, and National Institute of Mental Health (NIMH) Intramural Program (CHIP) Collaboration and the NIMH Genetics Initiative project. All participants underwent detailed, phenotypic assessment with either the Schedule for Affective Disorders and Schizophrenia-Lifetime Version or one of four versions of the Diagnostic Interview for Genetic Studies. Clinicians reviewed the interview items and derived variable definitions that were used to extract data from the original datasets. The combined data were subjected to range and logic assessments, and a subset was re-verified against the original data. Inconsistent data and variables that were deemed unreliable were excluded. Several of the resulting variables were characterized in the total cohort and tested for familial clustering, heritability, and statistical power in genetic linkage and association studies. Results: The combined database of phenotypic variables contained 197 variables on 5,721 subjects in 1,177 families. Deoxyribonucleic acid (DNA) samples are available for 5,373 of these subjects. The clinical presentation of bipolar disorder varied markedly. Most subjects suffered from serious and often disabling illness. Many phenotypic variables are strongly familial, and some quantitative variables are highly heritable. The cohort assembled in this study offers substantial power to carry out genetic linkage and association studies that use specific clinical features as covariates or as primary phenotypes. Conclusions: This is the largest database of phenotypic variables yet assembled for bipolar disorder, and it is now available to the research community. Researchers and clinicians can use this database to explore the connections between phenomenology and genetics in a cohort that is adequately powered to detect even modest genetic effects in bipolar disorder.
Acupuncture for Cardioversion
Authors: RONALD H. BERMAN
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 August 1973Acupuncture for CardioversionRONALD H. BERMAN, M.D.RONALD H. BERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-2-285_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to report two cases demonstrating a use of acupuncture that I have not seen previously described, cardioversion of supraventricular tachycardia.The first case is that of an 87-year-old retired minister who was admitted to Brookside Hospital because of rapid heart action. He had no prior history of this condition. Electrocardiograms showed atrial fibrillation with a rapid ventricular response of about 160. Digoxin, 0.5 mg, was given intramuscularly while I was enroute to the hospital. Since he had not converted by the time of my arrival, about a half hour later, acupuncture was tried at the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCardioversion of Atrial Fibrillation with AcupunctureNeural mechanisms of reflex inhibition of heart rate elicited by acupuncture-like stimulation in anesthetized ratsSympatho-inhibitory response of the heart as a result of short-term acupuncture-like stimulation of the rat hindlimb is not augmented when sympathetic tone is high as a result of hypercapniaThe effects of acupuncture on cardiac arrhythmias: A literature review 1 August 1973Volume 79, Issue 2Page: 285-285KeywordsAcupunctureAtrial fibrillationElectrocardiographyHeartTachycardia Issue Published: 1 August 1973 PDF downloadLoading ...
Intensive care in a district general hospital.
Authors: G S Crockett
Journal: BMJ (1973)

primigravide) one wonders how your con- tributors define toxaemia.There are several non sequiturs in the text which others among your readers will doulbt- less wish to question.I would only ask why, when they show themselves to be so progressive in their approach to the active management of labour, your contributors are so adamantly retrogressive in their attitude towards the management of pain in labour?-I am, etc.,
GP faces GMC hearing over 12 deaths at Gosport War Memorial Hospital
Authors: C. Dyer
Journal: BMJ (2009)

A GP accused of giving elderly patients excessive doses of opiates in the 1990s faces a hearing at the General Medical Council to decide whether she is fit to practise.

The allegations against Jane Barton relate to her treatment of 12 patients while she was working part time as a clinical assistant in elderly medicine at the Gosport War Memorial Hospital in Hampshire between January 1996 and November 1999 ( BMJ 2009;338:b1657, doi:10.1136/bmj.b1657).

An inquest into the deaths of 10 patients ended last April with a jury verdict that …
THE PSYCHIATRIC PATIENT, LIBERTY, AND THE LAW
Authors: RALPH SLOVENKO
Journal: American Journal of Psychiatry (1964)

Psychiatry is not wholly responsible for the evils in contemporary civil and criminal commitments. The law summons psychiatrists for inappropriate roles, and there is inadequate involvement of lawyers in the entire mental hospital field. And, to a considerable degree, the situation in mental hospitals actually mirrors community desiderata. Critics say that psychiatry is depriving people of their liberty and dignity. But what is psychiatry depriving them of? Their "right" to waste life?, to commit suicide?, to kill others? Traditionally, those dangerous to themselves or others, whether or not labelled mentally ill, have been isolated by society. The real question is: are we providing help appropriate to their needs? We must be more concerned, not less, over the needs of others.
Gastric Cancer—An Enigmatic and Heterogeneous Disease
Authors: Manish A. Shah, Jaffer A. Ajani
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophilic oesophagitis: a novel treatment using Montelukast
Authors: S E A Attwood
Journal: Gut (2003)

<b>Background:</b> Eosinophilic oesophagitis is a rarely diagnosed condition involving eosinophil infiltration of the oesophageal mucosa and creating significant symptoms of dysphagia. Failure to diagnose this disorder relates to reluctance to biopsy an apparently normal oesophagus. This is essential for histological diagnosis. To date, treatment success has been achieved only with corticosteroids. We describe here the use of an eosinophil stabilising agent Montelukast for the symptomatic relief of these patients. <b>Patients and methods:</b> Twelve patients have been identified with this condition in our unit since 1995, after thorough investigation of their dysphagia. We commenced eight of these patients on the leukotriene receptor antagonist Montelukast to symptomatically improve their swallowing while avoiding the use of long term corticosteroids. <b>Results:</b> Many of these patients had been previously misdiagnosed, and therefore inappropriately and unsuccessfully treated for an extensive period prior to referral to our unit. All patients were unresponsive to acid suppression therapy alone but showed improvement in their swallowing on Montelukast. Six of eight reported complete subjective improvement, five patients remaining completely asymptomatic on a maintenance regimen. <b>Conclusions:</b> Eosinophilic oesophagitis is a disease that is often misdiagnosed due to lack of awareness and reluctance of clinicians to biopsy an apparently normal oesophagus in dysphagic patients, and therefore obtain a histological diagnosis. Investigation of these patients adds further evidence to this condition being a separate pathological state from gastro-oesophageal reflux and eosinophilic enteritis. Montelukast has been found to be of significant help in the symptomatic control of these patients while avoiding long term corticosteroids use.
Should all casualty radiographs be reviewed?
Authors: J Wardrope, P M Chennells
Journal: BMJ (1985)

The effect on the management of patients of routine reporting of casualty radiographs by radiologists was reviewed. The overall prevalence of error by casualty doctors was 6.2%. Many of these errors, however, were trivial and did not alter treatment. In only 1.1% of the cases reviewed did the report of x ray films appreciably alter the management of the patient. A severity score was introduced to highlight those anatomical areas in which important lesions were overlooked most often. Radiologists' reports on radiographs of the chest, face, skull, and wrist had the greatest effect on management of patients, while reports on radiographs of fingers, hands, shoulders, long bones, and toes seldom altered treatment.
Expression of Fas ligand in Langerhans' cell histiocytosis: A case report of a boy with multisystem involvement
Authors: Ching-Tien Peng, Kuan-Chih Chow, Wu-Chung Chang, Chang-Hai Tsai, Tze-Yi Lin, Sheng-Shing Lin, Chan-Fang Chiu
Journal: American Journal of Hematology (1999)

Previous reports of patients with Langerhans' cell histiocytosis have shown characteristics of osteolytic lesion, visceral involvement and organ dysfunction. We report a 2-year-old boy who was diagnosed as Langerhans' cell histiocytosis with a prominent hepatomegaly. X-Radiogram, computed tomography and magnetic resonance imaging revealed the osteolysis of the right iliac bone, the absence of the left eighth rib as well as the right mandible, and an enhancing mass in the left cerebellum. The data of radiography were highly suggestive of Langerhans' cell lineage. The presence of large CD1a-positive mononuclear cells associated with inflammatory cells in peripheral blood smear and bone marrow aspirate further confirmed the diagnosis. In addition, expressions of S100, CD25, CD68, CD80, CD86, and Fas ligand were identified on these cells by immunocytochemical staining. The results indicate that although these cells are activated Langerhans' cells, progression of the disease and the bone destruction could be mediated by the overt FasL expression of the cells.
In vivo myocardial cell pH in the dog. Response to ischemia and infusion of alkali.
Authors: R M Effros, B Haider, P O Ettinger, S Ahmed Sultan, H A Oldewurtel, K Marold, T J Regan
Journal: Journal of Clinical Investigation (1975)

Myocardial cell pH has been measured with 5,5-dimethyl-2,4-oxazolidinedione (DMO) in intact anesthetized dogs by a transient indicator dilution technique. Bolus injections of labeled DMO, vascular, extracellular, and water indicators were made into the anterior descending coronary artery, and blood samples were collected from the great cardiac vein. The steady-state distribution of DMO between cells and plasma was calculated from the indicator mean transit times, and the plasma pH. Myocardial cell pH was determined from the distribution value and plasma pH. Normal myocardial cell pH averaged 6.94. Changes in myocardial cell pH after infusions of acid or alkali. Myocardial ischemia induced by inflation of a coronary artery balloon resulted in progressive decreases in cellular pH to average values of 6.83 within the initial 15 min and to 6.59 within the interval between 20 and 70 min. Infusions of Na2CO3 tended to diminish intracellular acidosis although these infusions had little effect on the difference in pH between the myocardial cell and extracellular fluid.
CONFUSIONAL INSANITY WITH EMPYEMA OF THE SPHENOIDAL SINUS
Authors: F. A. Pickworth
Journal: BMJ (1929)

T [zcBtJ 721 in his sinuses ran a definite risk of developing a more serious form of the infection.In actual fact 7 of the 88 patients (2 children, 5 adults) have lhad pr-oved pneumo- coccal or lobar pneumonia, and there are possibly more, as the significanice of the association has hithierto not been TABLE II.Children.All Cases.0 .
Excretion of Demethylchlortetracycline into the Bile
Authors: Calvin M. Kunin, Maxwell Finland
Journal: New England Journal of Medicine (1959)

DEMETHYLCHLORTETRACYCLINE is a new tetracycline antibiotic that was recently introduced for clinical evaluation.1 2 3 4 Its antibacterial spectrum is similar to that of the previously available analogues, — chlortetracycline, oxytetracycline and tetracycline, — and its activity against most of the common pathogenic bacteria in vitro is similar to, and in many cases greater than that of the other analogues.5 A striking feature of the new analogue is the higher and much more prolonged antibacterial activity that it produces in the blood.2 3 4 Thus, in a recent comparison of the dynamics of the distribution and excretion of the four tetracycline analogues,6 demethylchlortetracycline was found . . .
Factor Analysis of the Evaluation Form for Selecting Patients for Short-Term Anxiety-Provoking Psychotherapy
Authors: Karin Barth, Odd E. Havik, Geir Nielsen, Brit Haver, Ester Mølstad, Henrik Rogge, Marit Skåtun, Astrid Nøklebye Heiberg, Holger Ursin
Journal: Psychotherapy and Psychosomatics (1988)

The selection criteria of Sifneos' short-term anxiety-provoking psychotherapy has been assumed to consist of two separate dimensions, resources and motivation. A factor analysis revealed three factors: ego-resources, motivation for psychotherapy and motivation or desire to change. The resource items on the evaluation form constitute one factor as assumed, it is the items on the motivation section that are split into two independent factors. The evaluation form might become more useful if the motivation items are reorganized according to the two different dimensions of the concept.