tbuckley/cabot-search huggingface dataset:
Successful Reconstitution of Immunity in ADA-SCID by Stem Cell Gene Therapy Following Cessation of PEG-ADA and Use of Mild Preconditioning
Authors: H. Bobby Gaspar, Emma Bjorkegren, Kate Parsley, Kimberly C. Gilmour, Doug King, Joanna Sinclair, Fang Zhang, Aris Giannakopoulos, Stuart Adams, Lynette D. Fairbanks, Jane Gaspar, Lesley Henderson, Jin Hua Xu-Bayford, E. Graham Davies, Paul A. Veys, Christine Kinnon, Adrian J. Thrasher
Journal: Molecular Therapy (2006)

Gene therapy is a promising treatment option for monogenic diseases, but success has been seen in only a handful of studies thus far. We now document successful reconstitution of immune function in a child with the adenosine deaminase (ADA)-deficient form of severe combined immunodeficiency (SCID) following hematopoietic stem cell (HSC) gene therapy. An ADA-SCID child who showed a poor response to PEG-ADA enzyme replacement was enrolled into the clinical study. Following cessation of enzyme replacement therapy, autologous CD34+ HSCs were transduced with an ADA-expressing gammaretroviral vector. Gene-modified cells were reinfused following one dose of preconditioning chemotherapy. Two years after the procedure, immunological and biochemical correction has been maintained with progressive increase in lymphocyte numbers, reinitiation of thymopoiesis, and systemic detoxification of ADA metabolites. Sustained vector marking with detection of polyclonal vector integration sites in multiple cell lineages and detection of ADA activity in red blood cells suggests transduction of early hematopoietic progenitors. No serious side effects were seen either as a result of the conditioning procedure or due to retroviral insertion. Gene therapy is an effective treatment option for the treatment of ADA-SCID.
Correction: Acknowledgment for Paper on Coronary Bypass Surgery
Authors: William G. Kussmaul
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 May 1989Correction: Acknowledgment for Paper on Coronary Bypass SurgeryWilliam G. Kussmaul III, MDWilliam G. Kussmaul III, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-9-752 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the article by Deutsch and colleagues (1) in the 1 March 1989 issue, the acknowledgments should have included the following:Acknowledgments:The authors thank Neil Shusterman, MD, Renal-Electrolyte Section, Hospital of the University of Pennsylvania for help with the conception and design of this study....Reference1. DeutschBernsteinAddonizioKussmaul ERVW. Coronary artery bypass surgery in patients on chronic hemodialysis. A case-control study. Ann Intern Med. 1989;110:369-72. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital of the University of Pennsylvania Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1989Volume 110, Issue 9Page: 752-752KeywordsSurgery ePublished: 1 December 2008 Issue Published: 1 May 1989 PDF downloadLoading ...
A Randomized Controlled Trial of a Reduced Daily Dose of Zidovudine in Patients with the Acquired Immunodeficiency Syndrome
Authors: Margaret A. Fischl, Corette B. Parker, Carla Pettinelli, Michael Wulfsohn, Martin S. Hirsch, Ann C. Collier, Diana Antoniskis, Monto Ho, Douglas D. Richman, Edward Fuchs, Thomas C. Merigan, Richard C. Reichman, Jonathan Gold, Neal Steigbigel, Gifford S. Leoung, Suraiya Rasheed, Anastasios Tsiatis
Journal: New England Journal of Medicine (1990)

The initially tested dose of zidovudine for the treatment of patients with advanced disease caused by the human immunodeficiency virus type 1 (HIV) was 1500 mg. Although this dose is effective, it is associated with substantial toxicity.
Immune mechanisms in malaria: new insights in vaccine development
Authors: Eleanor M Riley, V Ann Stewart
Journal: Nature Medicine (2013)

Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a licensed vaccine will soon be available for use in endemic countries, but given the relatively low efficacy of the vaccine, this needs to be seen as a major step forward on the road to a malaria vaccine rather than as arrival at the final destination. The focus for vaccine developers now moves to the next generation of malaria vaccines, but it is not yet clear what characteristics these new vaccines should have or how they can be evaluated. Here we briefly review the epidemiological and immunological requirements for malaria vaccines and the recent history of malaria vaccine development and then put forward a manifesto for future research in this area. We argue that rational design of more effective malaria vaccines will be accelerated by a better understanding of the immune effector mechanisms involved in parasite regulation, control and elimination.
Can we afford screening for neural tube defects? The South Wales experience.
Authors: B M Hibbard, C J Roberts, G H Elder, K T Evans, K M Laurence
Journal: BMJ (1985)

Clinical and financial gains and losses accruing from five different options for screening for open neural tube defects were estimated, based principally on the results of detailed monitoring of inputs and outcomes and of process costs in the South Wales Anencephaly and Spina Bifida Study. As well as estimating the overall clinical costs of a screening service it was shown that if the prevalence, including terminations, of open neural tube defects is between 1.25 and five per 1000 births the financial cost of avoiding the birth of a seriously handicapped child who would survive for more than 24 hours is in the range 9000 pounds- 54000 pounds depending on the option adopted and the prevalence of the condition in the target population. Prevalence is the biggest determinant of cost. The data should provide a basis for assessment and discussion of resource priorities in the National Health Service.
Professional Education in a Long-Term-Care Facility: Program Development in Diabetes
Authors: Judith Wylie-Rosett, Mary Villeneuve, Roger Mazze
Journal: Diabetes Care (1985)

To effect diabetes care in a 1000-bed chronic care institution, a program development approach to multidisciplinary staff education was implemented. Chart audit, staff interviews, and observations were used to evaluate care standards. Initial assessment revealed that none of the charts included a thorough evaluation of patients for skills, knowledge, and adherence related to care of diabetes. Additionally, it was found that the current diagnostic criteria for diabetes and urine testing procedures were not being used. An educational approach was implemented to teach current information about diabetes, to focus on multidisciplinary coordination of care, and to set goals for care on model care units. Postintervention assessments of the model care units were completed at 6 and 24 mo. There were substantial alterations in care, with more of the charts meeting the standard in each of the eight categories under investigation: diabetes diagnosis according to National Diabetes Data Group criteria, urine testing, capillary blood testing, rotation of insulin injection site, assessment of patients for adherence to regimen, assessment of patient skills and knowledge, and interdisciplinary coordination of care.
West Nile virus spreads in United States
Authors: J. H. Tanne
Journal: BMJ (2002)

In the ongoing tension between the quest for profits and people's health care, "health can take precedence over trade issues," reassures a new joint study by the World Health Organization and the World Trade Organization (WTO)."If necessary, governments may put aside WTO commitments in order to protect human life," said the new report, WTO Agreements and Public Health.The principal coordinator of the study was Miguel Rodriguez Mendoza, deputy director general of the WTO.According to WTO jurisprudence, human health has been recognised as being "important in the highest degree," the report also said.Serious concerns have been raised that globalisation and the opening of trade barriers advocated under various WTO
Hypertension Due to Trauma of the Kidney
Authors: Stanley J. Zimmerman, Robert S. Radding
Journal: New England Journal of Medicine (1961)

IN 1937 Butler1 reported the removal of a pyelonephritic kidney in a patient who had hypertension and found that the hypertension improved. This was not totally unsuspected in view of the earlier work of Goldblatt et al.2 demonstrating in dogs that the kidney could produce hypertension. There remains little doubt that disease of one kidney, whether it is due to infection, impairment of blood supply or trauma, with the formation of scar tissue, may produce hypertension. As an increased number of cases of hypertension caused by unilateral renal disorders has accumulated, attention has been focused on the blood flow through . . .
Direct activation of neutrophil chemiluminescence by rheumatoid sera and synovial fluid.
Authors: R Gale, J V Bertouch, J Bradley, P J Roberts-Thomson
Journal: Annals of the Rheumatic Diseases (1983)

The majority of paired sera and synovial fluids from 21 patients with rheumatoid arthritis produced a rapid chemiluminescent response when incubated with human neutrophils. Synovial fluid gave considerably higher responses than the paired serum specimen. In contrast little or no response was found with paired sera and joint fluid taken from patients with gout, psoriasis, and osteoarthritis and with sera from healthy donors. A similar chemiluminescent response was observed when neutrophils were preincubated with large aggregates of heated human gammaglobulin (HAGG), which were used as a model of immune complexes. Smaller nonreactive aggregates of gammaglobulin became reactive after preincubation with a purified monoclonal rheumatoid factor (mRF) which had a high avidity for aggregated IgG. The addition of this monoclonal rheumatoid factor also caused enhancement of chemiluminescence by rheumatoid sera. Further evidence suggesting that the active material found in these rheumatoid specimens contained complexed immunoglobulin was obtained by indirect immunofluorescence. Neutrophils developed intracellular immunoglobulin inclusions after preincubation in reactive rheumatoid sera but not with nonreactive or normal sera. However, activation of neutrophil chemiluminescence by rheumatoid specimens did not correlate significantly with levels of rheumatoid factor or immune complexes suggesting that the activating complexes were of a particular type. In conclusion we have shown the direct activation of neutrophil chemiluminescence by rheumatoid sera synovial fluid and suggest that the activation is caused by large IgG-containing immune complexes. It is possible that this activation may have important implications in the immunopathogenesis of the rheumatoid inflammatory process.
Commonwealth and Common Health — Medical Care in Old Age — Byron's Lameness
Authors: John Lister
Journal: New England Journal of Medicine (1960)

THE recent annual meeting of the British Medical Association at Torquay was honored by the presence of the retiring President, H.R.H. Prince Philip. Characteristically, he arrived in a nearby meadow by helicopter and then made a brisk visit to the scientific exhibitions, presided at the presidential luncheon and inducted Sir Arthur Porritt as his successor before flying his helicopter back to London.For many reasons it was appropriate that Sir Arthur should embody the word Commonwealth within the title of his presidential address. Born in New Zealand himself, he was succeeding Prince Philip, who was also immediate past president of . . .
Twins' lawyers may demand change of venue for operation
Authors: C. Dyer
Journal: BMJ (2000)

The way was cleared last week for conjoined twins born in Britain to Maltese parents to be separated, when the unnamed parents announced that they would not contest an Appeal Court ruling that the operation should go ahead.

The couple came to Britain for the delivery after a scan showed they were expecting conjoined twins. Soon after the birth last August, they found themselves embroiled in a High Court battle after refusing to consent to an operation to separate them.

The twin girls are being cared for at St Mary's hospital in Manchester, …
Effect of jejunal infusion of bile acids on small bowel transit and fasting jejunal motility in man.
Authors: R Penagini, J J Misiewicz, P G Frost
Journal: Gut (1988)

The effect of jejunal infusion of glycochenodeoxycholic acid and glycocholic acid on small bowel transit time, fasting jejunal motility and serum bile acid concentrations was investigated in groups of five to six healthy subjects. Glycochenodeoxycholic acid at a concentration of 15 mmol/l (total amount: 5 mmol) and glycocholic acid 15 mmol/l (total amount: 5 mmol), both with lecithin 2.5 mmol/l, delayed (p less than 0.02) small bowel transit when compared with a bile acid free infusion [158.3 (12.5) min v 111.7 (17.6) min and 103.3 (21.8) min v 70.0 (14.9) min], inhibited (p less than 0.01 and p less than 0.05 respectively) the percentage duration of pressure activity of phase 2 [13.1 (1.8)% v 28.1 (3.4)% and 29.2 (5.5)% v 34.9 (3.9)%], but did not change duration of migrating motor complex, or of its phases. Glycochenodeoxycholic acid 10 mmol/l (total amount: 3.3 mmol), either with or without lecithin, did not delay small bowel transit significantly [145.0 (13.2) min v 115.0 (19.5) and 90.0 (11.7) min v 84.0 (8.3)]. When bile acids were infused, serum bile acid curves were similar to those obtained after a liquid meal and the peak serum bile acid concentration occurred 33.7 (6.6) min before (p less than 0.001) completion of small bowel transit. These observations suggest a role for endogenous bile acids in the regulation of small gut motility.
TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity
Authors: Stefano Angiari, Tiziano Donnarumma, Barbara Rossi, Silvia Dusi, Enrica Pietronigro, Elena Zenaro, Vittorina Della Bianca, Lara Toffali, Gennj Piacentino, Simona Budui, Paul Rennert, Sheng Xiao, Carlo Laudanna, Jose M. Casasnovas, Vijay K. Kuchroo, Gabriela Constantin
Journal: Immunity (2014)
237 Radiofrequency ablation versus surgical resection in the treatment of hepatocellular carcinoma; retrospective comparative study
Authors: C.M. Cho, K.T. Kwon, D.S. Lee, S.W. Jeon, Y.D. Lee, M.K. Lee, H.-E. Seo, C.K. Park, W.Y. Tak, Y.O. Kweon, S.K. Kim, Y.H. Choi, Y.J. Hwang, Y.I.L. Kim
Journal: Journal of Hepatology (2004)
Who Should do Psychotherapy?
Authors: J. Moor
Journal: BMJ (1970)

MDICJOUL 227 also been examined.This has a differently designed blood port gasket, and we found that although this is a loose gasket system bacteria tend to collect and survive beneath the blood port gasket in considerable numbers.This gasket was much more difficult to remove than the other type and was probably not-removed so regularly when the boards were disinfected.The use of loose gaskets has largely removed the sequestration of bacteria in the gasket channels.Thus there is a reduction in the bacterial challenge to the disinfection techniques, and, as these techniques will always suffer from the possibility of incomplete access of disinfectant either to the dismantled boards or to the assembled dialyser, there follows an improvement in the bacteriological state of the prepared dialyser and a reduction in the likelihood of bacterial proliferation during the subsequent dialysis.
Abstract 450: Head and neck cancer and HPV infection: A potential role for peritumoral neurogenesis in HPV-associated malignancy
Authors: Christian A. Graves, Swati Tomar, Diego Altomare, James R. Wells, Kim E. Creek, Lucia Pirisi
Journal: Cancer Research (2014)

Abstract Background: Head and neck cancers account for 5% of all cancer related deaths and present with complex molecular pathology and clinical features owing to their functional anatomical location. The molecular etiology of head and neck squamous cancer (HNSC) has gained extensive attention recently revealing key mutations, viral infection, and an emerging landscape of varying disease sub-types. While perineural invasion has long been associated with poor outcome in HNSC, the association of neurogenesis-related genes with cancer progression has only recently come into focus in HNSC. Using prospectively acquired patient samples and TCGA HNSC mutational analyses we further characterized the sequelae of molecular changes in neurogenesis-related genes and propose that these genes play a significant role in HNSC development. Methods: All clinical specimens were collected under approval by Institutional Review Board. Prospectively collected samples were analyzed for HPV DNA by linear arrays (InnoLipa) and q-PCR for E7-RNA. Gene expression arrays were conducted to determine differences in HPV activity and neuronal associated gene ontologies (Agilent). Gene expression profiles were compared in oral HPV+ and HPV- cultured oral keratinocytes as well as the TCGA Kandoth &amp; Tang datasets. Gene targets were validated by Immunohistochemistry and qPCR. Results: Initial unsupervised hierarchical clustering analysis of our HNSC cohort revealed a separation of HPV+ HPV+E7-(HPV-inactive: HPVin), and HPV- tumors with changes in the expression of key neurogenesis-related genes. For example, POU4F1, NGFR, and GRIN2C were significantly up-regulated (P&amp;lt;0.05) in HPV+ vs HPVin cancers. Additional analysis of TCGA data revealed divergence of the mutational spectra in HNSC with and without perineural invasion. Conclusion: Our preliminary findings indicate the emerging importance of neurogenesis-related genes and perineural involvement in HNSC and support a divergence of HPV+, HPVin, and HPV- HNSC sub-types. Citation Format: Christian A. Graves, Swati Tomar, Diego Altomare, James R. Wells, Kim E. Creek, Lucia Pirisi. Head and neck cancer and HPV infection: A potential role for peritumoral neurogenesis in HPV-associated malignancy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 450. doi:10.1158/1538-7445.AM2014-450
183 MANNOSE-BINDING LECTIN DEFICIENCY CONFERS RISK FOR INFECTIONS IN A LARGE HUNGARIAN COHORT OF PATIENTS WITH LIVER CIRRHOSIS
Authors: M. Papp, Z. Vitalis, I. Tornai, K. Palatka, S. Kacska, G. Farkas, M. Udvardy, J. Harsfalvi, T. Dinya, P. Orosz, B. Lombay, A. Par, G. Par, T. Csak, J. Osztovics, F. Szalay, A. Csepregi, P.L. Lakatos, I. Altrojay
Journal: Journal of Hepatology (2010)
THE RELATION OF NATURE'S PROVISION FOR HEART STIMULATION AND CONTROL TO THE USE OF CARDIAC DRUGS IN ACUTE DISEASE.
Authors: LOUIS FAUGERES BISHOP
Journal: JAMA (1904)

Before plunging into the indiscriminate use of drugs which have the property of causing the heart to beat more strongly, it is well to consider what provision has already been made in the same direction by the body itself, and also what is the precise object of such intervention in a particular case. The heart is wonderfully responsive to the demands of the body when subject to exertion or disease. In acute conditions, stimulation in the sense of urging the heart to expend more energy is seldom demanded except in sudden emergencies. Fever is a great heart stimulant, as is also inflammation. The use of the term "heart stimulants" in reference to drugs that are used in the course of disease with the idea of assisting the heart and preventing the failure of its powers when they may be most needed, is a crude employment of words and has led
Venom allergy in adult Swedes: a population study
Authors: E. Björnsson, C. Janson, P. Plaschke, E. Norrman, O. Sjöberg
Journal: Allergy (1995)

Hymenoptera allergies are a cause of considerable morbidity. However, deaths due to insect sting constitute a health hazard that can be minimized by effective therapy. We report the results of a study of 1815 men and women, aged 20–44 years and resident in three areas of Sweden. The prevalence of sensitization to the venom allergens of honeybees and wasps was assessed by RAST. Atopy and allergic diseases were considered possible risk factors for symptom development. Of the 1815 subjects, 1399 were randomly chosen from the general population. Of the random sample, 9.3% had specific bee or wasp IgE, 1.5% reported systemic reactions to bee or wasp stings, and 0.6% had both. Sensitization to bee or wasp correlated positively with atopy (odds ratio (OR) 2.0, confidence interval (CI) 1.4–2.8, P &lt;0.0001), male sex (OR 1.8, CI 1.3–2.5, P &lt;0.001), and age (OR 2.0, CI 1.4–2.8, P &lt;0.01), and negatively to living in the northernmost of the three centers (OR 0.4, CI 0.3–0.7, P &lt;0.001). Atopy was not found to be a risk factor for systemic reactions. We conclude that the prevalence of Hymenoptera allergy in Sweden is rather low when compared with other countries. Subjects with atopy seem to have an increased risk of becoming sensitized but do not develop systemic reactions more frequently than nonatopic subjects.
A new model for human bioassay of topical corticosteroids
Authors: B.S.N. REDDY, GURMOHAN SINGH
Journal: British Journal of Dermatology (1976)

The ability of topical corticosteroids to reduce the size of weals induced with histamine on human skin was used as a human bioassay model to assess their relative efficacy. Histamine was introduced by the pinprick method and various topical corticosteroids were assessed. It is a simple, easy and reliable procedure which can be used on both white and dark people. Even though it is a non‐clinical assay, it possesses close similarity to processes involved in the development of clinical dermatoses.