tbuckley/cabot-search huggingface dataset:
Telomere Length and Human Telomerase Reverse Transcriptase Expression As Markers for Progression and Prognosis of Colorectal Carcinoma
Authors: Ralf Gertler, Robert Rosenberg, Dominik Stricker, Jan Friederichs, Axel Hoos, Martin Werner, Kurt Ulm, Bernhard Holzmann, Hjalmar Nekarda, Joerg-Ruediger Siewert
Journal: Journal of Clinical Oncology (2004)

Maintenance of telomeres through reactivation of telomerase is a prerequisite for tumors to preserve their ability to proliferate. The purpose of this study was to evaluate telomere length and human telomerase reverse transcriptase (hTERT) expression as markers for progression and prognosis of colorectal carcinoma.Telomere length and hTERT expression were analyzed in matched cancer and adjacent noncancer mucosa samples from 57 patients with R0-resected colorectal carcinoma. The median follow-up time was 76 months.Telomere length and hTERT expression correlated significantly in cancer tissues and adjacent mucosa samples (r = 0.52, P <.001; and r = 0.54, P <.001, respectively). Overall, cancer tissue had shorter telomeres than adjacent mucosa (P <.001). Only in noncancer tissue did telomere length decrease with age (r = 0.36; P <.01). Telomere length in cancer tissue was significantly correlated with tumor stage (P <.01), with longer telomeres in advanced tumors. Patients with ratios of telomere length in cancer to noncancer tissue greater than 0.90 had a significantly poorer overall survival compared with patients with smaller telomere length ratios (P <.002). In multivariate analysis, the telomere length ratio proved to be of independent prognostic value (P <.03).Telomeres in colorectal carcinoma tissue were significantly shorter compared with adjacent normal mucosa as an indication for extensive cell proliferation. The correlation with tumor stage and patient survival suggest that hTERT-mediated telomere stabilization may be critical for progression and prognosis of colorectal carcinoma.
A complete mutation screen of PKHD1 in autosomal-recessive polycystic kidney disease (ARPKD) pedigrees
Authors: Sandro Rossetti, Roser Torra, Eliecer Coto, Mark Consugar, Vickie Kubly, Serafin Málaga, Mercedes Navarro, Mounif El-Youssef, Vicente E. Torres, Peter C. Harris
Journal: Kidney International (2003)
New government must reassess its criminal justice policy
Authors: T. McClintock
Journal: BMJ (1997)

Editor—Those who provide medical and psychiatric care to offenders see their work influenced not just by the health policies of the main political parties but by the parties' criminal justice policies. The cornerstone of the Conservatives' policy on law and order since 1993 has been the non-apologetic endorsement of imprisonment, based on the assertion that “prison works.” Since 1992 the prison population in England and Wales has increased by half to its current level of almost 60 000. This trend is likely to continue: proposals from …
Oncoplasty for lateral breast cancers.
Authors: RJ Salmon, F Reyal, M Berry, M Ballester, B Couturaud, A Fitoussi
Journal: Cancer Research (2009)

Abstract Abstract #5158 Introduction: 65% of breast cancers develop in the lateral pole, particularly superiorly. Following conservative treatment, , tumourectomy may produce a typical deformity of superolateral nipple-areolar complex (NAC) deviation. This unaesthetic deformity, is exaggerated by the post-operative irradiation mandated by contemporary breast conserving therapy. Primary utilisation of the oncoplastic technique, 'lateral mammaplasty', allows both the avoidance of such deformities and wider excision margins.&amp;#x2028; Patients and methods: The principle behind the technique is the combination of a wide, wedge-shaped tumourectomy combined with NAC repositioning on a de-epithelialised dermoglandular pedicle. Sentinel lymph node biopsy or formal axillary dissection may be performed simultaneously either via a separate or combined incision for inferior and superior lateral mammaplasties respectively. Aesthetic outcomes were assessed on a five-point scale with 1 being excellent and 5 poor.&amp;#x2028; Results: eighty-six patients, with a mean age of 53 years (range 29 – 75) underwent lateral mammaplasty. Fifty-five (64%) were palpable and 73 (86%) had simultaneous axillary surgery. Mean tumour size pre- and post-operatively were 29.8 mm (8 – 81) and 33.6 mm (0 – 140) respectively. Mean excision weight was 150g (24 – 484). Eleven (12.8%) required revisional surgery due to involved or close margins and the aesthetic outcome was graded highly satisfying or satisfying in 68 (79%).&amp;#x2028; Discussion: lateral mammaplasty has been found to be simple to perform with a short learning-curve. With clear excision margins in 87.8%, it is oncologically sound and compares favourably with simple tumourectomy. It should be considered when the tumour-to-breast volume ratio anticipates an aesthetic deformity. We have found it to be particularly satisfactory after neo-adjuvant chemotherapy for large volume tumours when a positive clinical response allows conservative surgery. It is also useful for revisional surgery in cases of involved or close margins following initial tumourectomy.&amp;#x2028; Conclusion: lateral mammaplasty became routine in our institution as it allows, with the assistance of a simple oncoplastic procedure, highly satisfying aesthetic outcomes and the added security of wide excision margins. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5158.
Partial Anomalous Pulmonary Venous Connection with Unusual Variations
Authors: Robert B. Kalmansohn, James V. Maloney, Richard W. Kalmansohn
Journal: New England Journal of Medicine (1961)

SINCE the development of effective surgical methods for treating congenital heart lesions there has been a renewed emphasis on clinical diagnosis. Anomalous pulmonary venous connection is one of the conditions in which the typical clinical syndrome has been clarified in recent years.1 2 3 4 5 6 7 We have studied 2 patients who presented unusual clinical variants of the syndrome.Case ReportsCase 1. A 10-year-old boy was first seen on May 13, 1958, with the complaints of wheezing, dyspnea and ankle edema. The symptoms were progressive and of 2 months' duration. Since the age of 5 years, he had had episodes of wheezing, which . . .
Pesticide in Lanolin
Authors: Peter H. Cade
Journal: JAMA (1989)

To the Editor. —  We note with some concern the letter 1 in which attention is drawn to the presence of residual pesticides in lanolin.  Croda Inc has been aware for several years of the possibility that substances, including pesticides from the agricultural environment, may remain in refined lanolin. The principal source of these residues is the treatment of sheep with a dip containing pesticides to reduce the infestation of the fleece with parasites.  It is possible to select wool greases of low pesticide content, however, and conventional refining technology that produces lanolin from wool grease will reduce these levels even further.  The Environmental Protection Agency has recently completed a risk assessment 2 in which it reviewed the results of pesticide analysis of lanolin-based emollients. This assessment was performed at the request of the Food and Drug Administration.  A worst-case scenario was postulated in which significant quantities of lanolin were ingested
Manual of Cardiac Surgery
Authors: James K. Condon
Journal: JAMA (1981)

The<i>Comprehensive Manuals of Surgical Specialties</i>represent the ongoing best efforts of series editor Richard H. Egdahl and the publishers (Springer-Verlag) to present the operative techniques employed in each of the surgical disciplines in full color, from the surgeon's point of view, and in perspective, beginning with the basics and advancing to highly sophisticated techniques. The first volume in the series,<i>Manual of Endocrine Surgery</i>, appeared six years ago at a price of $40; the page size was smaller (10 1/2×7 1/2 in) but there were more of them (274), so the amount of information contained is similar to the newest volume in the series, with its 204 pages (12×9 in), and comparisons are appropriate. The<i>Manual of Endocrine Surgery</i>, by Edis, Ayala, and Egdahl, remains the single most useful reference to this topic. Logically organized, superbly illustrated, and impeccably detailed, it unravels all the mysteries of surgical approaches to
A New and Only way of Raising the Epiglottis
Authors: B. Howard
Journal: BMJ (1888)

Amongst those I muist mention especially hay fever and parox- ysmal sneezing.In the post-nasal region the cure of adenoid vegetations has resulted in the prevention of deafness to such an extent that there are probably at least 100,000 persons now hear- ing well who, had it not been for Dr. Meyer's valuable discovery twenty years ago, would be hopelessly deaf.In this region, how- ever, there remains a disease which will tax all your energy and perseverance, all your talents and skill to overcome.I allude to the more severe form of post-nasal catarrh.Any specialist who can discover the means to cure this disease will deserve to rank by the side of Ilarvey or Jenner!In your future studies I would especially urge on you not to confine your attention to the graver or more out-of-the-way dis- eases.I feel convinced that there is a goo(l deal to be done in the somewhat uninteresting region of the minor aphonic ailments.Let me remind you that, lhowever dull suchi cases may be to the doctor, they are quite otherwise to the patient.lt is important, therefore, that even the most commonplace affection should be carefully studied.It is the experience of everyone, I suppose, that such cases, trivial as they are, are often the most difficult to cure.May not this be in part due to the very fact tlhait they are uninteresting?Those who are content perseveringly to inter- rogate Nature in her everyday dress will, I am persuaded, be fully compensated for such courageous humility.
Financing Long-Term Care
Authors: Paul J. Friedman
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 July 1988Financing Long-Term CarePaul J. Friedman, MDPaul J. Friedman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-2-172 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The Health and Public Policy Committee of the American College of Physicians has produced an excellent report on financing long-term care (1) and on long-term care for the elderly (2). My comments relate to the topic of long-term institutional care for the elderly. The best way to finance long-term institutional care for the elderly is to prevent institutionalization. Elderly persons are institutionalized for many reasons, such as medical or psychiatric illness, loneliness, care giver breakdown, and occasionally the insistence of overprotective relatives or ill-informed health workers. A new technology can cope with the mixed medical and psychosocial...References1. . Financing long-term care. Ann Intern Med. 1988;108:279-88. LinkGoogle Scholar2. . Long-term care of the elderly. Ann Intern Med. 1984; 100:760-3. LinkGoogle Scholar3. RubensteinJosephsonWielandEnglishSayreKane LKGPJR. Effectiveness of a geriatric evaluation unit: a randomized clinical trial. N Engl J Med. 1984;311:1664-70. CrossrefMedlineGoogle Scholar4. LeftonBonstelleFrengley ESD. Success with an inpatient geriatric unit: a controlled study of outcome and follow-up. J Am Ger Soc. 1983;31:149-55. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Paul J. Friedman, MDAffiliations: Waikato Hospital Hamilton New Zealand PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1988Volume 109, Issue 2Page: 172-173KeywordsElderlyHealth care policy reportsLong-term carePrevention, policy, and public healthPublic policy ePublished: 1 December 2008 Issue Published: 15 July 1988 PDF downloadLoading ...
EXOMPHALOS SUCCESSFULLY OPERATED ON.
Authors: I. F. HICKS
Journal: JAMA (1905)

Umbilical hernia occurs in three different forms: The umbilical hernia of infants and young people, due to the weakening of the umbilical cicatrix, which yields before intra-abdominal pressure. This condition rarely persists until adult life and is readily amenable to treatment. The umbilical hernia of adults, usually due to a protrusion of omentum or intestine through an opening in the linea alba either just above or below the umbilicus. This form usually requires operative treatment. The congenital umbilical hernia, or exomphalos, which is an exceedingly rare condition due to the imperfect closure of the abdominal walls, as a result of which the intestine is not entirely withdrawn into the abdomen at birth, but is found in a cavity at the base of the umbilical cord, which is bulbous and enlarged. If the condition is overlooked it may be included in the ligature with which the cord is tied, causing fatal
Cotton Dust, Smoking, and the Lung
Authors: PHILIP C. PRATT
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 April 1984Cotton Dust, Smoking, and the LungPHILIP C. PRATT, M.D., WILLIAM S. LYNN, M.D.PHILIP C. PRATT, M.D.Search for more papers by this author, WILLIAM S. LYNN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-618_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Beck and associates (1) point out that the data analyzed in our recent letter (2) do not pertain solely to retired cotton workers but instead to all cotton workers for whom the 6-year follow-up observation was done. A reexamination of the data in Table 4 of the original article (3) shows that it included 379 follow-up cases among whom there were 101 active workers (27%) and 278 retirees (73%). Tables 6.10 to 6.13 in their report (4) deal with a total of 367 cases and thus include both retirees and active workers. However, we do not agree...References1. BECKSCHACHTERMAUNDERSCHILLING GELR. Cotton dust and the lung [Letter]. Ann Intern Med. 1984; 100:162. LinkGoogle Scholar2. PRATTLYNN PW. Lung disease in cotton workers [Letter]. Ann Intern Med. 1983;99:278. LinkGoogle Scholar3. BECKSCHACHTERMAUNDERSCHILLING GELR. A prospective study of chronic lung disease in cotton textile workers. Ann Intern Med. 1982;97:645-51. LinkGoogle Scholar4. BECKMAUNDERSCHACHTERSCHILLING GLER. Follow-up of Active and Retired Cotton Textile Workers. Report to the U.S. Department of Labor. Springfield, Virginia: National Technical Information Service, 1982. Publication no. PB 82-240516. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PHILIP C. PRATT, M.D.; WILLIAM S. LYNN, M.D.Affiliations: Duke Medical Center Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLung Function in Cotton-Textile WorkersGERALD J. BECK, PH.D., E. NEIL SCHACHTER, M.D., LUCINDA R. MAUNDER, M.A., RICHARD S.F. SCHILLING, M.D., D.SC. 1 April 1984Volume 100, Issue 4Page: 618-619KeywordsDustLungs ePublished: 1 December 2008 Issue Published: 1 April 1984 PDF downloadLoading ...
THE INFLUENCE OF BEJEL ON THE SECOND GENERATION
Authors: ELLIS H. HUDSON, SUSAN S. CKOSLEY
Journal: British Journal of Dermatology (1936)

Journal Article THE INFLUENCE OF BEJEL ON THE SECOND GENERATION Get access ELLIS H. HUDSON, M.D., ELLIS H. HUDSON, M.D. Deir‐ez‐Zor, Syria Search for other works by this author on: Oxford Academic Google Scholar SUSAN S. CKOSLEY, M.D. SUSAN S. CKOSLEY, M.D. Deir‐ez‐Zor, Syria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 48, Issue 6, 1 June 1936, Pages 288–299, https://doi.org/10.1111/j.1365-2133.1936.tb10347.x Published: 01 June 1936
Abstract 922: Association of the <i>hSRBC</i> gene polymorphism with endometrial cancer
Authors: Seo-yun Tong, Jong-Min Lee, Seon-Kyung Lee, Hyeyeon Han, Min-Ju Kang, Sung-Gil Chi
Journal: Cancer Research (2010)

Abstract Background: hSRBC is a putative tumor suppressor located at 11p15.4, at which frequent genomic loss has been observed in several human malignancies. We previously reported that hSRBC expression is frequently downregulated in many types of human cancers due to aberrant promoter CpG sites hypermethylation, and hSRBC activation induces cell cycle arrest and apoptosis by enhancing the protein stability of p53. Interestingly, our recent studies suggest that hSRBC might be a novel transcription target of TNFα, which plays a crucial role in inflammation and tumorigenesis. We explored the possible association of an intreaexonic SNP (T509C), which results in a Leu to Pro substitution, with risk for endometrial cancer development. Methods: TNFα regulation of hSRBC expression was examined using semi-quantitative RT-PCR and immunoblot assays. Endometrial tissues from 147 cancer patients and 191 healthy individuals were included for test for SNP T509C by restriction endonuclease PvuII-based genotyping. Allele frequencies in cancer specimens were compared with those in healthy controls. Results: Allelic frequencies of T and C at the T509C position was 30.27% and 69.73% in healthy control and 37.17% and 62.83% in cancer specimens, respectively. Allelic frequency at T509C in cancer specimens showed no significant difference compared to controls. However, genotype frequencies of TT, CT, and CC in healthy controls were 16.75%, 40.84%, and 42.412%, respectively, while cancer specimens displayed 14.97%, 30.61%, and 54.42%. The CC genotype frequency in cancer specimens was significantly higher (p &amp;lt; 0.05) compared with that in healthy controls. Conclusion: Although the number of specimens used in this study is not enough, this study raises the possibility that the T509C SNP of hSRBC, a putative novel transcription target of TNFα and proapoptotic tumor suppressor, might be associated with endometrial cancer development. Further genotype screening of several other SNPs within hSRBC in cancer patients would provide valuable diagnostic and prognostic information for human cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 922.
And Then There Were None: The Demise of National Medical Television
Authors: Campbell Moses
Journal: JAMA (1995)

To the Editor.  —Your editorial comments in JAMA concerning The Demise of National Medical  1 are right on target! As the founding director of the National Medical Audiovisual Center (NMAC), I can attest to the value of a national policy governing information important to the future of the health sciences. During the NMAC's lifetime, we were successful in assisting schools of the health professions establish departments of biomedical communication, offering such technical assistance as was required. A course was charted in the production area, and prototype materials were prepared and made widely available. A demonstration (Community Medical Television System) was created, and the first schedule of live programming was received at installations in and around Atlanta, Ga. Program offerings included surgery, medicine, and other specialties, and scheduled viewing times were made known to personnel in all cooperating installations. With the New York Academy of Sciences, the NMAC sponsored an
THE TEACHING OF PRACTICAL DIETETICS IN MEDICAL SCHOOLS.
Authors: R. O. BEARD
Journal: JAMA (1902)

In state legislatures within the past two years the medical profession has had to defend itself against the ancient presumption that its practice is essentially based upon the administration of drugs, while other so-called systems of healing have claimed exemption from the operation of medical practice laws upon the plea that their followers do not employ medicinal agents. The contention is an odd one in days when therapeutic nihilism has widely invaded the ranks of the profession of medicine, but it has, together with that nihilistic tendency, a common cause. Drug dosage is not the dominant rule of practice that it once was, howsoever the reputation of that rule clings persistently to the skirts of the profession. But, while medicinal measures have been finding their proper place in the treatment of disease, other and non-medicinal measures have been rising into recognition and awaiting their assignment to a fit place in the
Pharmacodynamics of Propranolol in Renal Failure
Authors: F. D. Thompson, A. M. Joekes, D. M. Foulkes
Journal: BMJ (1972)

The pharmacodynamics of propranolol were studied in patients with renal functional impairment. <sup>14</sup>C-labelled propranolol was given either intravenously or by mouth and the disappearance rates of propranolol, 4-hydroxypropranolol, and total radioactive metabolites measured. The renal clearance of total radioactive compounds is directly related to renal function. The half-life of total radioactivity is greatly lengthened in the presence of severe renal failure while the half-lives of the pharmacologically active propranolol and 4-hydroxymetabolite are slightly reduced. There is a suggestion that the absorption of propranolol is delayed in renal failure. No known pharmacological action or side effects from the other metabolic products of propranolol have been recognized. There is still too little well-documented evidence concerning the beta-blocking activity of the unidentified major metabolites of propranolol to suggest any alteration in the dosage regimen used in renal failure.
Influence of T lymphocytes on hematopoiesis in a patient with T cell hypoplasia
Authors: Ronald Hoffman, Li Lu, Jan Jansen, Edward Bruno, John Brandt, Leonard Boral, Killian Cheung
Journal: American Journal of Hematology (1988)

Abstract In this communication, we describe an unusual patient with a reported lifelong history of anemia. Investigation of the pathogenesis of this patient's bone marrow failure provided an interesting opportunity to determine the role of T cells in the regulation of human blood cell production. Phenotyping of the patient's mononuclear cells revealed severe T cell hypoplasia in both the peripheral blood and bone marrow. The patient's bone marrow was capable of producing 50–60% of the normal numbers of burst‐forming units—erythroid (BFU‐E) in the presence of optimal concentrations of erythropoietin, suggesting that marrow BFU‐E formation is in part independent of T cells. Addition of small numbers of class I identical donor T cells enhanced BFU‐E cloning efficiency to a level observed in normal controls. This enhancing effect was supplied by a T4 + (CD4) population of donor cells. The addition of donor T cells partially corrected the inability of patient marrow cells to produce megakaryocyte and mixed colonies. These studies suggest that prolonged T cell hypoplasia might deprive marrow progenitor and stem cells of a necessary enhancing effect that is required for sustained normal hemato‐poiesis. Such a T cell defect in rare instances may result in bone marrow failure.