tbuckley/cabot-search huggingface dataset:
“Fiancees'” Graves Disease
Authors: Vincenzo Bacci
Journal: Annals of Internal Medicine (1993)

Letters1 February 1993“Fiancees'” Graves DiseaseVincenzo Bacci, MD and Vincenzo Giammarco, MDVincenzo Bacci, MDSearch for more papers by this author and Vincenzo Giammarco, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ebner and colleagues [1] described the clinical and laboratory features of a six-member family with Graves disease and encouraged reports of other clusters.Patient 1A 27-year-old man developed symptoms of hyperthyroidism in December 1987, and on presentation in May 1988 he had a small (40-g), diffuse goiter. He had elevated T4 (251 nmol/L) and T3 (6.7 nmol/L) levels and homogeneous and elevated uptake on thyroid scan (88% at 6 hours and 80% at 24 hours). Thyrotropin-binding inhibitory immunoglobulins (TBII) were present at a low titer (12%; normal, < 10%). He was started on tapazole, 30 mg daily, ...REFERENCE1. Ebner SA, Badonnel MC, Altman LK, Braverman LE. Conjugal Graves disease. Ann Intern Med. 1992; 116:479-81. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 232KeywordsAntibodiesHaplotypesHuman leukocyte antigenHyperthyroidismPeroxidasesResearch laboratoriesThyroidThyroid diseasesThyroid hormonesTriiodothyronine Issue Published: 1 February 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
320 THE VALUE OF A NEW SCORE (PREDICTION LIVER FIBROSIS SCORE – PLF SCORE) FOR THE ASSESSMENT OF FIBROSIS IN CHRONIC HCV HEPATITIS
Authors: S. Bota, R. Sirli, I. Sporea, M. Focsa, A. Popescu, M. Danila, M. Strain, M. Sendroiu, A. Deleanu, A. Tudora, I. Dan
Journal: Journal of Hepatology (2011)
Precocious Microangiopathy in Young Healthy Males.
Authors: F. A. Elliott
Journal: Annals of Internal Medicine (1968)

s1 May 1968Precocious Microangiopathy in Young Healthy Males.F. A. Elliott, F.R.C.P., S. C. Leonberg, M.D.F. A. Elliott, F.R.C.P.Search for more papers by this author, S. C. Leonberg, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1154_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBiomicroscopy of the conjunctival microcirculation in a large number of stroke patients has revealed the consistent presence of dynamic and morphological changes in venules, capillaries, and small arteries. The dynamic changes include sludging of red blood cells, slowing of flow, and areas of stasis. The morphological abnormalities, which we have designated degenerative microangiopathy, include tortuosity of small arteries and veins, localized ectasia of venules, micropools or microaneurysms, or both, and avascular areas. Similar abnormalities have been found in the cerebral microcirculation by Russell, Hassler, Scheinker, Fang, and others.A milder degree of degenerative microangiopathy has been observed in a number... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1154-1154KeywordsArteriesCapillariesMicrocirculationRed blood cellsStrokeVeinsVenules Issue Published: 1 May 1968 PDF downloadLoading ...
Screening for abdominal aortic aneurysm
Authors: Roger Greenhalgh, Janet Powell
Journal: BMJ (2007)

A recent Cochrane review has updated our knowledge about screening asymptomatic people for abdominal aortic aneurysm, with respect to their mortality, subsequent treatment for the aneurysm, and the cost effectiveness of screening.1 Four completed randomised controlled studies—Chichester, Viborg, Western Australia, and the multicentre aneurysm screening study (MASS)—with 127 891 men and 9342 women (only the Chichester trial included women) aged from 65-83
SUSPENSIO UTERI.Read in the Section of Obstetrics and Diseases of Women, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: H. A. KELLY
Journal: JAMA (1893)

Cases of retroflexion of the uterus which can not be relieved by palliative treatment, and in which there is good reason to believe that the position and posture of the uterus have a causative relationship to persisting aches and pains, are suitable cases for the operative treatment of the retroflexion. It should be accepted as a cardinal fact that no retroflexion should be treated by a direct operation when associated with a relaxed vaginal outlet unless the latter be repaired at the same time or as soon after as possible. In some cases it will be proper to lift up the vaginal outlet, neglecting entirely the retroflexion. In other cases the retroflexion and the relaxed outlet will be treated at the same sitting. The best operation for retroflexio uteri is the one which is applicable to the greatest number of cases, producing the largest percentage of recoveries, and the best
The Experience of Open Heart Surgery
Authors: Chase P. Kimball
Journal: Psychotherapy and Psychosomatics (1970)

In this report we focus on 11 items used by nurses in rating behavior in the three-week period following cardiac surgery and correlate these with data collected pre-operatively in terms of adaptation, extent of illness, and psychological tests, operative, and post-operative factors. Those patients, who showed greater pre-operative adaptation, were less ill, scored lower on emotional distress, had fewer complications at operation, and a more benign post-operative course, showed less behavioral disturbance. These results serve to emphasize the complex interrelationships between neurological and psychological variables in determining behavior and are reminiscent of much of the work done by Kurt Goldstein with patients who had chronic organic brain syndromes [15].
Wild-Mushroom Intoxication as a Cause of Rhabdomyolysis
Authors: Regis Bedry, Isabelle Baudrimont, Gerard Deffieux, Edmond E. Creppy, Jean P. Pomies, Jean M. Ragnaud, Michel Dupon, Didier Neau, Claude Gabinski, Sten De Witte, Jean C. Chapalain, Jacques Beylot, Pierre Godeau
Journal: New England Journal of Medicine (2001)

The growing popularity of eating wild mushrooms has led to an increase in the incidence of mushroom poisoning. Most fatalities are due to amatoxin-containing species, which cause fulminant hepatocytolysis, and to cortinarius species, which lead to acute renal damage. A 1996 report described a patient with hepatic failure, encephalopathy, and myopathy related to the ingestion of Amanita phalloides.1 Since 1992, 12 cases of delayed rhabdomyolysis have occurred in France after meals that included large quantities of the edible wild mushroom Tricholoma equestre.2 The circumstances of these 12 cases clearly implicate T. equestre as the cause. The mushroom was . . .
The concept of control in COPD: a new proposal for optimising therapy
Authors: Juan José Soler-Cataluña, Bernardino Alcázar-Navarrete, Marc Miravitlles
Journal: European Respiratory Journal (2014)

To the Editor: 

Chronic obstructive pulmonary disease (COPD) is a very heterogeneous disease and therefore treatment should be individualised considering the different clinical characteristics and severity of each patient [1–3]. In an attempt to identify individuals with similar characteristics and response to treatment, a group of experts has defined the “clinical phenotypes” of COPD as those attributes of the disease alone or in combination that “describe differences between individuals with COPD in relation to parameters that have clinical significance (symptoms, exacerbations, response to treatment, rate of progression disease, or death)” [4]. Therefore, the clinical phenotype should be able to classify patients into subgroups with prognostic value and to determine the most appropriate therapy to achieve better results from a clinical standpoint.

However, even patients with similar clinical characteristics and degree of airflow obstruction may have a different expression of their disease or present with short-term changes in their state that may require changes in treatment. Therefore, the new concept of disease control, similar to the “control of asthma” concept should be added in the assessment of patients with COPD. But, what is control in COPD?

Control is a new dimension in the evaluation of patients with COPD, after the evaluation of symptoms, comorbidities and the degree of severity based either on the impairment in lung function or on any multidimensional prognostic indices. Control is a dynamic concept; as an example, two patients who are the same age, have the same level of symptoms and same level of airflow obstruction, with two exacerbations in the current year, may have different degrees of clinical control. One of the patients may have had four exacerbations in the previous year and so comparatively control has improved, whereas the second patient may have had no exacerbations the …
"HOW TO BUDGET HEALTH"
Authors: Evans Clark
Journal: JAMA (1933)

To  Editor:  —Several misstatements appear in  review of How  Budget Health, inThe Journal, April 1.  The reviewer says that the methods used  recruit members [of medical guilds] are  paid advertisements,  direct mail promotion and  personal solicitation—methods that are contrary  recognized ethical ideas.  I specifically opposed  use of paid advertisements in promoting medical guilds. This form of promotion,  book states,  most vulnerable on ethical grounds and should probably not be resorted to (p. 194). The only direct mail promotion advocated is in  form of announcements sent  their patients  doctors who join  staff of a guild, or announcements of  adoption of  guild plan  an existing medical institution (p. 195). As for personal solicitation,  only kind advocated in  book is by  word of mouth of satisfied patrons, who would naturally, without
Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor
Authors: Stephen Willey, Angel Ayuso-Sacido, Hailan Zhang, Stuart T. Fraser, Kenneth E. Sahr, Matthew J. Adlam, Michael Kyba, George Q. Daley, Gordon Keller, Margaret H. Baron
Journal: Blood (2006)
LYMPH PRESSURES IN STERILE INFLAMMATION
Authors: Madeleine E. Field, Cecil K. Drinker, James C. White
Journal: The Journal of Experimental Medicine (1932)

1. The normal lymph pressure in the legs of anesthetized dogs is not measurable. 2. The maximum pressure of lymph in the quiescent leg under conditions of sterile inflammation is around 120 cm. of lymph. 3. Venous pressure rises immediately in a region subjected to sterile inflammation and then slowly returns to normal. The rise in lymph pressure follows the rise in venous pressure. 4. Changes in lymph flow, lymph pressure, and protein concentration of the lymph occur when the part producing lymph is subjected to external temperatures between 50 degrees and 60 degrees C.
Influence of NPM1 and FLT3-ITD status on outcome in relapsed/refractory AML patients receiving salvage therapy including gemtuzumab ozogamicin
Authors: P Chevallier, T Prebet, A Pigneux, M Hunault, J Delaunay, F Perry, L Lode, S Richebourg, O Blanchet, N Vey, N Ifrah, N Milpied, D Blaise, J-L Harousseau, M Mohty
Journal: Leukemia (2009)
On Ethics and Advocacy
Authors: William E. May
Journal: JAMA (1986)

Organized medicine has been urged to take a firmer stand in declaring physician participation in the business aspects of medicine to be unethical. The author maintains that physicians must adjust to new realities and reassert control over medical care and compensation. Passive acceptance of the role of physician-employee may result in loss of the ability to respond to patients' needs, while involvement in business may allow physicians to use their positions for patient advocacy and to fund improved care or to increase compensation lost to discounted fees. Physicians must be active in developing new health care services and businesses to insure quality and avoid loss of control; organized medicine must have faith in professional integrity.
Orthotopic Liver Transplantation in Groningen, The Netherlands (1979-1983)
Authors: Ruud A. F. Krom, Chris H. Gips, Hendrik J. Houthoff, Douglas Newton, Dirk V. D. Waaij, José Beelen, Elizabeth B. Haagsma, Maarten J. H. Slooff
Journal: Hepatology (1984)

From March, 1979 to March, 1983, 26 orthotopic liver transplantations and 1 retransplantation were performed in our center. Sixteen patients are alive, 5 beyond 2 years and 1 longer than 4 years after transplantation. The actuarial 1- and 2-year survival is 60%. Factors contributing to this result are patient selection and biliary anastomosis. In cirrhotic patients, the degree of deterioration of liver function correlated with survival; in patients with hepatocellular carcinoma, extrahepatic spread of tumor was the most frequent limiting factor. Choledochocholedochostomy with a widening plasty had a low complication rate providing that the arterial blood supply was undisturbed. Until now, HLA-matching has not contributed to the result of liver transplantation, although the effect for long-term survival is still unknown. The high survival rate and excellent quality of life of long-term survivors justify liver transplantation as treatment for otherwise noncurable liver diseases.
Medical Consequences of Natural Disasters
Authors: Clark W. Heath
Journal: JAMA (1986)

Everywhere in the world potential exists for natural disasters: hurricanes on the Gulf coast, volcanic eruptions in Colombia, famine in the Sahel, tidal waves (tsunami) in Japan. Although the natural forces that generate such cataclysms are beyond human control, we can blunt their human effects by systems of preventive action through communication networks, community planning, and emergency response preparedness (evacuation plans, medical care, public health controls, and nutrition support). The purpose of this short book (160 pages) is to provide blueprints for such preventive action, described largely in the context of the author's extensive professional experiences, accumulated over the past four decades. Preventive strategies are described in successive chapters for earthquakes, tsunami, floods, mudflows and avalanches, and famine, and then in more general terms for various stages of any disaster emergency with particular regard to medical care and public health actions. The book also contains a chapter on traffic injuries,
The States and Health Care Reform
Authors: Michael S. Dukakis
Journal: New England Journal of Medicine (1992)

IN 1945 Harry Truman became the first president in U.S. history to propose a universal health plan for all Americans. Forty-seven years later, the American people are still waiting.True, we have made some progress since the days when a massive lobbying effort by the American Medical Association and the nation's insurers shot down the Truman plan. But two Republican presidents who supported universal, employer-based health insurance in the 1970s could not get their proposals through Congress. President Carter preferred to focus on cost containment in health care rather than on universal coverage. And neither Ronald Reagan nor George Bush . . .
Expression, of the thrombospondin receptor (CD36) on the cell surface in megakaryoblastic and promegakaryocytic leukemias: Increment of the receptor by megakaryocyte differentiation in vitro
Authors: Nobutaka Imamura, Hiromi Ota, Kazuhiro Abe, Atsushi Kuramoto
Journal: American Journal of Hematology (1994)

In this report we describe four cases of acute megakaryocytic leukemia demonstrated by the presence of megakaryocyte-platelet-related cell-surface antigens. These were detected utilizing flow cytometry and monoclonal antibodies in addition to both platelet peroxidase activity, which was shown by ultrastractural cytochemistry, and emergence of differentiation antigens, while culturing these leukemic cells. The blasts of one patient possessed both platelet GpIb and GpIIb/IIIa cell-surface antigens detected by AN51(CD42b), J15, P2, and HPL2(CD41), respectively, whereas the remaining three patients almost completely lacked GpIb cell-surface antigen. Hence the former were diagnosed as immature(pro)megakaryocytic leukemia and the latter as acute megakaryoblastic leukemia from the viewpoint of immunophenotypic analysis. While we cultured these leukemic cells in conditioned medium prepared from phytohemagglutinin-stimulated leukocytes and interleukin 3, expression of CD36(OKM5) antigen (thrombospondin receptor) increased gradually according to the differentiation and maturation of these cells. Finally, all leukemic cells differentiated to mature megakaryocytes. The function of CD36 on these cells remains to be elucidated.
Medical Witnesses and the Adversary System
Authors: Richard P. Bergen
Journal: JAMA (1976)

In the commentary by Aring (p 569), there is a proposal that physicians should refuse to testify in legal proceedings unless called as a witness by the court rather than by one of the parties. If followed, this proposal would raise some critical problems for the administration of justice. In some circumstances, an impartial medical witness called by the court may be appropriate. In 1961, both the American Medical Association and the American Bar Association endorsed in principle the concept of "impartial medical testimony." Programs of this kind have been established in several jurisdictions. In these programs, any party may call expert medical witnesses in addition to the one called by the court. A "battle of experts" in which medical witnesses give contradictory opinions in testimony may sometimes be embarrassing for the medical profession. This may be especially true in the area of mental illness. Nevertheless, it is not always
Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism
Authors: N ORIE, C FRY, L CLAPP
Journal: Cardiovascular Research (2005)

Objective: We investigated the role of the inward rectifier potassium (KIR) channel and the cyclic AMP-dependent pathway in mediating vasorelaxation induced by the prostacyclin analogue cicaprost. Methods: Small vessel myography was used to assess responses to cicaprost in segments of rat tail artery contracted with phenylephrine. Microelectrode recordings were made from helical strips to assess effects on membrane potential. Results: Cicaprost caused relaxation and hyperpolarisation that were significantly inhibited by Ba2+ (30–100 μM), a known blocker of KIR channels. Raising extracellular K+ from 5 to 15 mM elicited membrane hyperpolarisation and an endothelium-independent relaxation that was blocked by Ba2+ (30–100 μM), suggesting the existence of functional KIR channels on the smooth muscle. In contrast, neither glibenclamide (10 μM), a blocker of ATP-sensitive K+ channels, nor fluoxetine hydrochloride (100 μM), a blocker of G-protein-gated inward rectifier K+ channels, nor pertussis toxin (PTX; 1 μg/ml), which irreversibly inhibits Gi/Go, reduced relaxation to cicaprost. Indeed, PTX significantly potentiated responses. Relaxation to cicaprost was not mediated by NO but was partially endothelium-dependent, consistent with a similar inhibition by a combination of charybdotoxin (0.1 μM) and apamin (0.5 μM), blockers of endothelium-derived hyperpolarising factor (EDHF). However, relaxation was unaffected by adenylyl cyclase (SQ22536, dideoxyadenosine) or protein kinase A (Rp-2-O-monobutyryl-cAMP) inhibitors, consistent also with Ba2+ only weakly inhibiting relaxation to the adenylyl cyclase activator forskolin. Conclusion: We conclude that cicaprost relaxes rat tail artery by activating KIR channels with some involvement from EDHF. The mechanism appears to be largely independent of cyclic AMP and Gi/Go, although the latter appears to counteract relaxation through an unknown pathway and/or receptor.
Denver Health: A Model for the Integration of a Public Hospital and Community Health Centers
Authors: Patricia Gabow, Sheri Eisert, Richard Wright
Journal: Annals of Internal Medicine (2003)

Two major pillars of the United States' safety net system are urban public hospitals and community health centers. Their common mission is to care for the uninsured and other vulnerable populations. However, in most communities these important components of the safety net remain organizationally and functionally separate, which inhibits the continuum of care and creates substantial inefficiencies. Denver Health is a long-standing vertically and horizontally integrated system for vulnerable populations. The integration benefits the patient and the system and serves as a model for the U.S. safety net. This paper outlines the benefits of integration to the patient, provider, and health system, using data from the National Association of Public Hospitals and Health Systems, the Bureau of Primary Health Care, and Denver Health.
Road traffic noise and psychiatric disorder: prospective findings from the Caerphilly study
Authors: S. Stansfeld, J. Gallacher, W. Babisch, M. Shipley
Journal: BMJ (1996)

Although environmental noise causes annoyance, there is little evidence from studies of psychological symptoms, psychotropic drug use, mental hospital admissions, and community studies that it causes psychiatric disorder.1 Exposure to aircraft noise was not associated with psychiatric disorder in a cross sectional survey in west London,2 but the population exposed to noise may have been biased by prolonged noise exposure and may represent “survivors” of noise, the most vulnerable to noise having moved away or never having moved into the noisy area. The relation between traffic noise at baseline and psychiatric disorder at follow up is explored in the Caerphilly collaborative heart disease study, a population unlikely to have been selected by noise exposure.

In the second phase of the Caerphilly study all men aged 50-64 years living in Caerphilly, south Wales, were invited to attend a screening clinic.3 Follow up was carried out five years later. Street measurement of A-weighted sound pressure level (dB(A)) was …
Validation of the Association Between Neurologic Improvement With Decline in Blood Pressure and Recanalization in Stroke
Authors: Leonard L. L. Yeo, Yao F. Chong, Vijay K. Sharma
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Long-term transfusion independence in del(5q) MDS patients who discontinue lenalidomide
Authors: A A N Giagounidis, A Kulasekararaj, U Germing, R Radkowski, S Haase, P Petersen, G Göhring, G Büsche, C Aul, G J Mufti, U Platzbecker
Journal: Leukemia (2011)