tbuckley/cabot-search huggingface dataset:
Hepatic encephalopathy in a liver transplant recipient with stable liver function
Authors: Juan Pablo Arab, Luis Meneses, Rosa M. Pérez, Marco Arrese, Carlos Benítez
Journal: Hepatology (2013)

Postshunt hepatic encephalopathy after liver transplantation (LT) is an infrequent condition and is commonly associated with portal occlusion or stenosis and the presence of a patent portosystemic shunt. Portal vein stenosis (PVS) or thrombosis (PVT) are uncommon complications after LT. The overall frequency of both complications is reported to be less than 3%. When PVS or PVT develop early after LT, the occlusion of the portal vein can have catastrophic consequences to the graft including acute liver failure and graft loss. Late PVT/PVS are asymptomatic in approximately 50% of the cases and mainly diagnosed by a routine ultrasound. Symptomatic postshunt hepatic encephalopathy (HE) is a very infrequent condition after LT that has been scarcely reported in the literature. We present here the case of a liver recipient with normal graft function who presented with hepatic encephalopathy 3 months after LT with stable liver function but a severe portal stenosis and the presence of a spontaneous portosystemic shunt whose successful endovascular treatment was followed by the complete resolution of the HE.
Abstract 5109: Proteomics of murine BRCA1 deficient breast tumors identifies DNA repair proteins with prognostic value in human breast cancer
Authors: Marc O. Warmoes, Janneke Jaspers, Maarten P.G. Massink, Thang Pham, Sander R. Piersma, Sven Rottenberg, Epie Boven, Hanne Meijers-Heijboer, Quinten Waisfisz, Jos Jonkers, Connie R. Jimenez
Journal: Cancer Research (2011)

Abstract Background: Breast cancer is the most common malignancy in women in the western world. The outcome of breast cancer would be strongly improved if patients could be diagnosed and treated early. This especially holds for patients with hereditary breast cancer. Aim: Our aim is to identify proteins that are associated with BRCA1 deficient hereditary breast cancer. These proteins could have potential use as screening, prognostic or predictive biomarkers. Approach: In-depth proteome profiling of tumor tissues of mouse breast cancer models was employed to identify BRCA1-associated proteins. To this end, tumor tissue lysates of five BRCA1 deficient and five proficient mouse models (Liu et al., 2007) were fractionated using SDS-PAGE followed by tryptic in-gel digestion, nanoLC-MS/MS and database searching. Normalized spectral counting was used for protein quantification and beta binomial statistics to discover significantly regulated proteins. Ingenuity Pathway Analysis and COFECO protein complex analysis was used to support data interpretation. The prognostic power was assessed by the use of publicly available gene expression human breast cancer data sets. Results: We identified a total of 3614 proteins, of which 804 were differential between the genomic instable BRCA1-deficient and the genomic stable BRCA1-proficient breast tumors. Pathway analysis and protein complex identified DNA-repair and associated function like chromatin modeling and RNA processing as the major functions associated with the upregulated proteins of the BRCA1 deficient tumors. We created a core DNA-repair protein signature using pathway and protein Complex analysis. When the signature proteins were mapped to human breast cancer gene-expression data sets, they were shown to have prognostic power. Conclusion: Proteomics of genetic mouse models for familial breast cancer is a powerful strategy to discover novel candidate BRCA1 deficiency proteins with human relevance. The major upregulation of DNA-repair complexes may indicate a compensatory mechanism for loss of BRCA1 DNA-repair. Further validation studies are required to investigate prognostic candidates in tissue microarrays. Integration with data on tumor and cancer cell-secreted proteins will pinpoint which of the BRCA1 deficiency associated proteins may have potential for screening of BRCA1 tumors and whether they have predictive value for sensitivity to PARP1 inhibition and Cisplatin treatment in BRCA1 as well as non-BRCA1-deficient tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5109. doi:10.1158/1538-7445.AM2011-5109
Aseptic Meningitis and Intravenous Immunoglobulin Therapy
Authors: Marinos C. Dalakas
Journal: Annals of Internal Medicine (1995)

Letters15 February 1995Aseptic Meningitis and Intravenous Immunoglobulin TherapyMarinos C. DalakasMarinos C. DalakasSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-4-199502150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The products and lots of intravenous immunoglobulin preparations we used for patients 1 and 4 Table 1 of our article [1]) were 3 monthly infusions of the same lot of Gamimune 5% (Miles, Inc., West Haven, Connecticut); these patients developed aseptic meningitis after each infusion. Patient 1 received 14 additional twice monthly infusions, 6 with different lots of Gamimune and 8 with Gammagard (Baxter Healthcare, Glendale, California). He again developed aseptic meningitis after each infusion except with the last two. Patient 2 developed aseptic meningitis after receiving 1 infusion of Gamimune 5%; he subsequently received 13 monthly infusions ...References1. Sekul EA, Cupler EJ, Dalakas MC. Aseptic meningitis associated with high-dose intravenous immunoglobulin therapy: frequency and risk factors. Ann Intern Med. 1994; 121:259-62. Google Scholar2. De Vlieghere FC, Peetermans WE, Vermylen J. Aseptic granulocytic meningitis following treatment with intravenous immunoglobulin. Clin Infect Dis. 1994; 18:1008-10. Google Scholar3. Scribner CL, Kapit RM, Phillips ET, Rickles NM. Aseptic meningitis and intravenous immunoglobulin therapy. Ann Intern Med. 1994; 121:305-6. Google Scholar4. Ronda N, Haury M, Nobrega A, Continhio A, Kazatchkine MD. Selectivity of recognition of variable regions of autoantibodies by intravenous immunoglobulin (IVIg). Clin Immunol Immunopath. 1994; 70:124-8. Google Scholar5. Grosse-Wilde H, Blasczyk R, Westhoff V. Soluble HLA class I and class II concentrations in commercial immunoglobulin preparations. Tissue Antigens. 1992; 39:74-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmunotherapy in the Treatment of Autoimmune Neuromuscular DiseasesThe use of intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: evidence-based indications and safety profileImmunoglobulin for rheumatic diseases in the twenty-first centuryIntravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: Present status and practical therapeutic guidelinesACUTE ASEPTIC MENINGITIS SECONDARY TO INTRAVENOUS IMMUNOGLOBULIN IN A PATIENT WITH KAWASAKI SYNDROME 15 February 1995Volume 122, Issue 4Page: 316-317KeywordsBacterial meningitisHealth careHuman leukocyte antigenIdiopathic thrombocytopenic purpuraIntravenous immunoglobulinKawasaki diseaseLumbar punctureMeningitisSpecificitySubarachnoid hemorrhage Issue Published: 15 February 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Treated Cytomegalovirus Pneumonia Is Not Associated with Bronchiolitis Obliterans Syndrome
Authors: Michael Tamm, Christina L. Aboyoun, Prashant N. Chhajed, Stephen Rainer, Monique A. Malouf, Allan R. Glanville
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

The association of cytomegalovirus (CMV) infection with the development of bronchiolitis obliterans syndrome (BOS) is unclear. We studied 341 lung transplant recipients to assess whether histopathologically diagnosed CMV pneumonia treated with ganciclovir was a risk factor for development of BOS and patient survival. We also analyzed the relationship between CMV donor/recipient serologic status and BOS plus the temporal association between acute rejection and CMV pneumonia. Freedom from BOS for patients with (n = 151) and without (n = 190) CMV pneumonia was 83 and 90% (1 year), 52 and 56% (3 years), and 29 and 38% (5 years), respectively (p = 0.2660). Cumulative survival of patients with and without CMV pneumonia was 90 and 93% (1 year), 70 and 74% (3 years), and 58 and 63% (5 years), respectively (p = 0.1811). There were no significant differences in either development of BOS or patient survival with any combination of donor/recipient serostatus for CMV. Acute rejection occurred in the month preceding CMV pneumonia in 62 of 193 (32%) cases. Histopathologically confirmed CMV pneumonia treated with ganciclovir is not a risk factor for BOS or patient survival, nor is any particular CMV serologic donor/recipient group. CMV pneumonia often follows acute rejection, perhaps as a result of augmented immunosuppression.
MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA
Authors: Wade H. Brown
Journal: The Journal of Experimental Medicine (1913)

1. Intravenous injections of alkaline hematin in the rabbit produce an anemia the severity of which is proportional to the amount of hematin injected and the susceptibility of the animal. 2. Hemoglobinemia is an occasional consequence of hematin poisoning. 3. The leucocytes in hematin intoxication are usually increased in number and are always characterized by a high percentage of large mononuclear cells and by pigmented phagocytes. 4. The platelets are markedly reduced by alkaline hematin and ultimately a prolongation of the coagulation time of the blood and of the bleeding time results. 5. The anemia, the hemoglobinemia, the high percentage of large mononuclear leucocytes, the destruction of platelets, and the tendency to hemorrhage in malaria are all influenced by the malarial pigment, hematin.
SOME PHENOMENA OF TUBERCULOSIS INFECTION.
Authors: WILLIAM PORTER
Journal: JAMA (1906)

The study of tuberculosis is a many-sided proposition. It is not my purpose now to attempt a full résumé of the subject or to discuss at length any of its more important features, but rather to make certain suggestions which have been the outgrowth of daily contact with victims of this most interesting and universal disease. I omit statistics—encouraging as they are—or detailed description of the methods of limitation and plans of organizations which have already been so effective. My thought is to discuss some of the phenomena of tuberculous infection and possibly to make a few therapeutic suggestions as legitimate deductions. <h3>THE BACILLUS.</h3> Naturally, the bacillus is the central point in most of the experiments and investigations concerning tuberculosis. To some it might seem that almost two decades of study had sufficed to learn all that is to be known of this organism, yet, I believe that we are
Long-term survival of salivary streptococci on dental devices made of ethylene vinyl acetate
Authors: Taiji Ogawa, Sayaka Yamasaki, Mariko Honda, Yutaka Terao, Shigetada Kawabata, Yoshinobu Maeda
Journal: International Journal of Oral Science (2012)

Bacterial infection associated with the use of medical or dental devices is a serious concern. Although devices made of ethylene vinyl acetate (EVA) are often used in the oral cavity, there are no established standards for their storage. We investigated bacterial survival on EVA sheets under various storage conditions to establish a standard for hygienic storage of such dental devices. Bacterial counts were evaluated, which showed a significant decrease after washing with sterilized water, mechanical brushing and rinsing, and using Mouthguard Cleaner as compared to untreated samples. In addition, no bacteria were detected on samples stored 2 days or longer in a ventilated environment, whereas they were detected for up to 14 days on samples without any cleaning stored in a closed environment. Bacterial counts for the untreated samples gradually declined, while surviving bacteria on samples treated with sterilized water and mechanical brushing showed a rapid decrease. Additionally, bacterial identification using polymerase chain reaction (PCR) revealed that Streptococcus oralis was dominantly detected on salivary samples after 14 days of storage among both two subjects. For effective hygienic storage of dental devices made of EVA, washing with sterilized water is important to remove absorbed salivary compounds along with storage in a ventilated environment.
15 minute consultations as standard benefit patients and GPs
Authors: G. J. Irving, J. Holden
Journal: BMJ (2012)

Spence claims that increasing appointments to 15 minutes would reduce availability, limit access, and jeopardise safety with an unknown effect on the quality of patient care.1 We have offered 15 minute appointments as standard in our practice for eight years with huge benefits for our patients and us.2 This is not unusual—a national survey showed that 1 …
Ventilatory and Arousal Responses to Hypoxia and Hypercapnia in a Canine Model of Obstructive Sleep Apnea
Authors: R. JOHN KIMOFF, DINA BROOKS, RICHARD L. HORNER, LOUISE F. KOZAR, CAROLINE L. RENDER-TEIXEIRA, VICTORIA CHAMPAGNE, PIERRE MAYER, ELIOT A. PHILLIPSON
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

We have previously described a canine model of obstructive sleep apnea (OSA) in which sleep–wake state is monitored continuously by a computer that produces tracheal occlusion when sleep occurs. Our aim was to assess the effects of long-term application of this model on resting ventilation and on the ventilatory and arousal responses to hypercapnia and hypoxia. Five dogs were maintained on the model for 15.5 ± 1.7 (mean ± SE) wk, with a mean apnea index of 57.5 ± 4.5 occlusions/h of sleep. Resting ventilation and the ventilatory and arousal responses to progressive hypoxic and hypercapnic rebreathing were assessed during wakefulness (W) and both slow-wave (SWS) and rapid-eye-movement (REM) sleep at baseline prior to intervention, at the end of the OSA phase, and following a 1 to 3-mo recovery period. During the period of OSA there were small changes in respiratory timing at rest, but no significant changes in Pco 2 or SaO2 . As compared with baseline, the ventilatory response to hypoxia during OSA was strikingly reduced during W, and significantly although less markedly reduced during SWS and REM. The reduction was due to a decreased breathing frequency response to hypoxia. In addition, during OSA there was a significant decrease from baseline in SaO2 at arousal during hypoxic rebreathing in both SWS and REM. All responses returned to normal during recovery. In contrast to hypoxia, hypercapnic ventilatory responses during OSA were slightly increased over their baseline values both in W and SWS, owing to a leftward shift of the ventilation-versus-Pco 2 relationship. During recovery, these responses reverted partly to baseline for W and reverted completely to baseline for SWS. There were no significant changes in arousal Pco 2 during hypercapnic rebreathing in either SWS or REM across the pre-OSA baseline, OSA, and post-OSA recovery periods. We conclude that long-term application of the OSA model is associated with a selective, reversible decrease in ventilatory and arousal responses to hypoxia.
Comparison of attendance and emergency admission patterns at accident and emergency departments in and out of London.
Authors: R F Jankowski, S Mandalia
Journal: BMJ (1993)

OBJECTIVE--To compare the sociodemographic characteristics, diagnoses, and mode of referral of people and emergency admissions between an accident and emergency department in inner London and one in a town outside London. DESIGN--Standardised questionnaire completed prospectively over two weeks by field-workers in each accident and emergency department. SETTING--Accident and emergency departments in an inner London teaching hospital and an associated teaching hospital outside London. SUBJECTS--3039 adults newly attending the departments, 1476 in inner London and 1563 outside London. MAIN OUTCOME MEASURES--Sociodemographic characteristics, diagnosis, mode of referral, and whether the patient was admitted. RESULTS--General practitioner referrals accounted for similar proportions of the adult attendances (12% in inner London, 15% outside London). People attending at the inner London department were more likely to be tourists or long distance commuters (12% (179/1476) v 6% (95/1563)), single (43% (643) v 32% (505)), to live alone (24% (360) v 14% (225)), to have moved recently (13% (194) v 7% (107)), or to be homeless (3.3% (48) v 0.6% (10)). Broad clinical groupings of patients were similar in both departments. 291 people were admitted in inner London and 284 outside London. The proportions admitted from each sociodemographic group were similar in the two hospitals. CONCLUSION--Differences in sociodemographic characteristics were more important than general practice referral patterns in determining the differences in people attending at accident and emergency departments inside and outside London. Many of these characteristics are likely to be found in other inner city populations. A strategy to improve acute care in inner London should take account of the needs of these sociodemographically different groups.
IMPORTANCE OF VASCULAR PERMEABILITY IN THE RADIOTHERAPY OF CANCER
Authors: Gustav Peter
Journal: JAMA (1927)

To  Editor:  —InThe Journal, Nov. 6, 1926, page 1537, Dr. A. U. Desjardins states, in his article on Stimulation and Immunity in Radiotherapy, that the major effect of radium or roentgen rays is a direct one, and that  false notion that  partial regression of a tumor resulting from irradiation is due to products elaborated in some mysterious way and leading to some vague form of immunity is based on a misinterpretation or an abuse of  word stimulation.  I must take issue with such statements for  following reason:  An epithelioma of  scleral conjunctiva, involving  corneal margin and surrounded by hundreds of dilated capillaries, save in  corneal part of  margin which is avascular, was treated with radium for six days. Six days after  last treatment  vascular scleral margin had not advanced any more, while  avascular corneal edge had pushed
739. Impact of Activation, Transduction/Selection Steps on the Gene Expression Profile of Ex-Vivo Retrovirally Transduced CD8+ T Cells, Using High Density DNA Microarrays
Authors: Marina Deschamps, Jean Marie Certoux, John de Vos, Nicolas Montcuquet, Thierry Reme, Mark Bonyhadi, Eric Robinet, Pierre Tiberghien, Christophe Ferrand
Journal: Molecular Therapy (2005)

Suicide gene therapy clinical approaches using retrovirally transduced donor T-lymphocytes (GMTC) have led to successful alloreactivity modulation following bone marrow transplantation. We have previously shown that our GMTC production method: 12 day ex-vivo culture in the presence of IL-2, entails phenotypical and functional alterations. Such alterations can be limited partly by CD3/CD28 activation before retroviral transduction, plus immunomagnetic selection based on cell surface membrane gene expression, i.e truncated Nerve Growth Factor (|[Delta]|NGFR).
Multihospital Data on Appendicitis
Authors: Edward J. Kobrinski
Journal: JAMA (1982)

<h3>To the Editor.—</h3> We are encouraged by the recommendation in the article by Detmer et al, "Regional Results of Acute Appendicitis Care" (1981; 246:1318), that "a periodic review of multihospital performance data should help hospital medical staffs identify where the performance of their institutions deserves a more detailed review and subsequent action." We disagree, however, with their statement that multihospital data on appendicitis are not routinely available. The Commission on Professional and Hospital Activities (CPHA) has collected such data routinely for the last 25 years through hospital participation in the Professional Activity Study throughout the United States and other countries (currently 1,627 hospitals. Performance data on all discharges, including appendicitis patients, are routinely available through the Quality Assurance Monitor [QAM], an ancillary program at CPHA since 1974). Hospitals that choose to receive QAM reports have their data compared with regional norms and industry standards currently derived from 1979 data. Mortality
Radiology of uncomplicated asthma
Authors: M. E. Hodson, G. Simon, J. C. Batten
Journal: Thorax (1974)

<b>Hodson, Margaret E., Simon, G., and Batten, J. C. (1974).</b><i>Thorax</i>, <b>29</b>, 296-303. <b>Radiology of uncomplicated asthma.</b> In 22 of the 117 patients with asthma, over 15 years of age, the chest radiograph showed overinflation (O<sub>1</sub> pattern) and additional vascular changes in two (O<sub>2</sub> pattern). Neither abnormality was seen in 60 controls. Abnormal radiographs were found in 31% of patients whose asthma started before the age of 15 but in none of those in whom it started over 30 years of age. The mean age of patients with abnormal radiographs was 24·6 years, compared with 40·1 years for those with normal films. Radiographic changes bore no relation to duration of disease. In some cases the abnormality persisted; in others it was present only during the acute episode.
CASE OF URETHRAL CALCULUS, PROSTATIC DIVISION
Authors: D. Lee Hirschler
Journal: JAMA (1913)

Urologic literature contains numerous references to urethral calculi, over one hundred reports being recorded, from many of which important lessons can be learned. The most frequent variety of urethral calculus is that of the single impacted stone, of vesical origin, caught behind one of the physiologic narrowings of the urethra or behind a stricture. In the case here reported it is evident that had the strictured area been kept dilated for some time after the prostatectomy, the calculus would not have formed.  The purpose in reporting this case is to demonstrate a roentgenogram taken of the calculus in situ.   Patient.  —Charles A., aged 61, single, civil engineer, born in Massachusetts, was admitted Jan. 10, 1913. His father died at advanced age, his mother in childbirth. There was no history of cancer or tuberculosis. The patient denied lues, and had never been ill except as will be described. He was addicted