Trazodone and Liver Toxicity
Authors: ANTHONY G. CHU
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 July 1983Trazodone and Liver ToxicityANTHONY G. CHU, M.D., BRENT L. GUNSOLLY, B.S., ROBERT W. SUMMERS, M.D., BRUCE ALEXANDER, PHARM. D., CHERYL MCCHESNEY, M.D., V.L. TANNA, M.D.ANTHONY G. CHU, M.D., BRENT L. GUNSOLLY, B.S., ROBERT W. SUMMERS, M.D., BRUCE ALEXANDER, PHARM. D., CHERYL MCCHESNEY, M.D., V.L. TANNA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-1-128_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Trazodone, a popular non-tricyclic antidepressant has been recently marketed in the United States. Its principal advantages include a low incidence of anticholinergic and cardiovascular side effects (1). Drowsiness and dizziness have been the major side effects (2). There have been no reports of liver toxicity due to trazodone. We report a case of liver toxicity possibly resulting from a therapeutic trial of trazodone.A 63-year-old man was admitted for treatment of a chronic major depressive disorder. On admission the patient was on phenelzine sulfate and diazepam (both since 1978) and digoxin (since 1978). Values at admission included...References1. BROGDENITELLSPEIGHTAVERGY RRTG. Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs. 1981;21:401-29. CrossrefMedlineGoogle Scholar2. AL-YASSIRIANTSIERBRIDGES MSP. Trazodone: a new antidepressant. Life Sci. 1981;16:2449-58. CrossrefGoogle Scholar3. ZIMMERMAN H. Drug induced liver disease. Drugs. 1978;16:24-45. CrossrefGoogle Scholar4. EBERTSHADER MR. Hepatic effects. In: SHADER RI, DI MASCIO A, eds. Psychotropic Drug Side Effects: Clinical and Theoretical Perspectives. Baltimore: Williams and Wilkins Co.; 1970:175-97. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Iowa Iowa City Veterans Administration Medical Center Iowa City, IA 52242 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySuspected hepatotoxicity secondary to trazodone therapy in a dogAntidepressant-Induced Acute Liver Injury: A Case–Control Study in an Italian Inpatient PopulationTrazodoneHepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stagesFulminant Hepatic Failure Induced by Venlafaxine and Trazodone Therapy: A Case ReportANTIDEPRESSANTSChapter 3 Applications of Quadrupole-Linear Ion Trap Mass Spectrometry to the Analysis of Reactive Metabolites in Drug Discovery and DevelopmentIn Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and BuspironeAntidepressant-lnduced Liver InjuryTrazodoneMetabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4Antidepressant-induced hepatotoxicityHepatotoxicity after Short-Term Trazodone TherapyThe use of psychotropics in the medically illTrazodone-Induced Hepatotoxicity: A Case Report With Comments on Drug-Induced HepatotoxicityHepatotoxicity of psychotropic drugsHEPATOTOXICITY OF ANESTHETICS AND OTHER CENTRAL NERVOUS SYSTEM DRUGSIdiosyncratic reactions to antidepressants: A review of the possible mechanisms and predisposing factors9 Drug-induced cholestasisTrazodone-induced hepatotoxicity and leukonychiaAntidepressant drugsTrazodone and Intrahepatic CholestasisKHALID H. SHEIKH, M.D., ALAN S. NIES, M.D. 1 July 1983Volume 99, Issue 1Page: 128-129KeywordsDiazepamLiverMajor depressive disorderSulfatesToxicity Issue Published: 1 July 1983 PDF DownloadLoading ...