tbuckley/cabot-search huggingface dataset:
Purpura caused by UV-irradiation at 375 nm in a patient with hydroa vacciniforme
Authors: K. Sato, M. Tsujimura, Y. Kitano, K. Yoshikawa
Journal: British Journal of Dermatology (1991)

Journal Article Purpura caused by UV‐irradiation at 375 nm in a patient with hydroa vacciniforme Get access K. Sato, K. Sato Department of Dermatology, Osaka University School of Medicine, 1‐1‐50 Fukushima, Osaka 553, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Tsujimura, M. Tsujimura Department of Dermatology, Osaka University School of Medicine, 1‐1‐50 Fukushima, Osaka 553, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Kitano, Y. Kitano Department of Dermatology, Osaka University School of Medicine, 1‐1‐50 Fukushima, Osaka 553, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Yoshikawa K. Yoshikawa Department of Dermatology, Osaka University School of Medicine, 1‐1‐50 Fukushima, Osaka 553, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 4, 1 April 1991, Pages 396–397, https://doi.org/10.1111/j.1365-2133.1991.tb00613.x Published: 01 April 1991
English surgeons call for improved management of head injury
Authors: R. Woodman
Journal: BMJ (1999)

The Royal College of Surgeons of England warned in a report published last week that patients with head injuries are experiencing avoidable disabilities or dying unnecessarily because services are insufficiently funded.

The college's working party report on the management of patients with head injuries said that resources—in terms of staffing, facilities, and beds—available for treating the one million cases …
MAINTENANCE OF REMISSION IN ACUTE MYELOGENOUS LEUKÆMIA BY A MIXTURE OF B.C.G. AND IRRADIATED LEUKÆMIA CELLS
Authors: R.L. Powles, P.J. Selby, D.R. Tones, J.A. Russell, H.G. Prentice, T.J. Mcelwain, P. Alexander
Journal: The Lancet (1977)
Ultrasonography Before Abortion?
Authors: J. Jay Crittenden
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The patient treatment flow chart in "Fatal Ectopic Pregnancy After Attempted Legally Induced Abortion" (1980;244:1705) suggests that the best way to ensure the absence of ectopic pregnancy is to identify chorionic villi at the time of abortion. However, the authors themselves indicate that identification of chorionic villi may not be easy, and "if doubt persists, the specimen should be sent for a pathologist's review." The flow chart is also interesting in that sonography is mentioned at the bottom as an apparently last-ditch effort to untangle complicated situations. I would like to suggest that a much more direct and positive approach is to confirm intrauterine pregnancy by sonography before the abortion procedure. If there is an intrauterine pregnancy, one can rule out ectopic pregnancy, except for the extremely rare ectopic gestation coexisting with intrauterine pregnancy. If the uterus is empty in the face of a truly positive pregnancy
Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure.
Authors: A Matsumori, T Shioi, T Yamada, S Matsui, S Sasayama
Journal: Circulation (1994)

BACKGROUND Vesnarinone, a quinolinone derivative, is a recently synthesized positive inotropic agent that has been shown to dramatically improve the survival of patients with heart failure. However, the mechanism of action of vesnarinone remains unknown. Reversible neutropenia complicated with vesnarinone therapy suggests that vesnarinone may modulate the production of cytokines. Because tumor necrosis factor (TNF)-alpha and other cytokines have been shown to depress myocardial contractility, we investigated the effects of vesnarinone on the production of various cytokines. METHODS AND RESULTS We studied the effects of vesnarinone on cytokine production by lipopolysaccharide (LPS)-stimulated whole blood from seven patients with heart failure and from five healthy volunteers. Heparinized blood was diluted in RPMI and stimulated with LPS. Vesnarinone was added in a range of 1 to 30 micrograms/mL, the blood was incubated for 24 hours, and interleukin (IL)-1 alpha, IL-1 beta, IL-6, TNF-alpha, interferon (IFN)-gamma, and granulocyte colony-stimulating factor (G-CSF) were measured by an enzyme-linked immunosorbent assay. LPS stimulation induced a more prominent increase in TNF-alpha in patients with heart failure than in healthy volunteers. Vesnarinone inhibited the production of TNF-alpha and IFN-gamma both in healthy volunteers and in patients with heart failure. IL-1 alpha and IL-1 beta were also suppressed in healthy volunteers, but this response was variable, and a significant reduction was not seen in patients with heart failure. Marked inhibition of G-CSF and other cytokines by vesnarinone was observed in one patient who had developed neutropenia as a result of vesnarinone therapy. CONCLUSIONS Although the number of study patients was small and the results are preliminary, these findings provide evidence that vesnarinone plays an important role in the regulation of cytokines and suggest that the reduction of cytokine release may contribute to the beneficial effects of the drug in the treatment of heart failure. Furthermore, the measurement of cytokines may be useful in predicting the occurrence of neutropenia, which has been occasionally reported in patients treated with vesnarinone.
Prescribing medicines for children
Authors: A. G Sutcliffe
Journal: BMJ (1999)

All parents would like the drugs administered to their child to have been fully evaluated using studies based in children (but not their child). However, infants and older children present a challenge for drug monitoring and testing, and there are far fewer clinical studies designed to test drugs in children than to test them in adults. The factors that limit such studies include technical constraints such as blood sampling. There are also ethical difficulties in involving children in studies that may not directly benefit them, even if the studies involve minimal risk. Fortunately, with the development of new non-invasive methods to measure drug concentrations therapeutic drug monitoring will be less limited by the necessity for blood sampling.1 Moreover, drug regulatory authorities and professional bodies are beginning to address the need to test drugs for children in the same way as those for adults.

The disposition of drugs in children varies from that in adults because children differ from adults pharmacokinetically and pharmacodynamically. Factors such as growth, surface area, organogenesis, enzyme …
Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice
Authors: A. M. Mabe, D. B. Hoover
Journal: Cardiovascular Research (2009)

Previous work provided indirect evidence that the neurotrophic factor neurturin (NRTN) is required for normal cholinergic innervation of the heart. This study used nrtn knockout (KO) and wild-type (WT) mice to determine the effect of nrtn deletion on cardiac cholinergic innervation and function in the adult heart. Immunohistochemistry, confocal microscopy, and quantitative image analysis were used to directly evaluate intrinsic cardiac neuronal development. Atrial acetylcholine (ACh) levels were determined as an indirect index of cholinergic innervation. Cholinergic function was evaluated by measuring negative chronotropic responses to right vagal nerve stimulation in anaesthetized mice and responses of isolated atria to muscarinic agonists. KO hearts contained only 35% the normal number of cholinergic neurons, and the residual cholinergic neurons were 15% smaller than in WT. Cholinergic nerve density at the sinoatrial node was reduced by 87% in KOs, but noradrenergic nerve density was unaffected. Atrial ACh levels were substantially lower in KO mice (0.013 ± 0.004 vs. 0.050 ± 0.011 pmol/μg protein; P < 0.02) as expected from cholinergic neuron and nerve fibre deficits. Maximum bradycardia evoked by vagal stimulation was reduced in KO mice (38 ± 6% vs. 69 ± 3% decrease at 20 Hz; P < 0.001), and chronotropic responses took longer to develop and fade. In contrast to these deficits, isolated atria from KO mice had normal post-junctional sensitivity to carbachol and bethanechol. These findings demonstrate that NRTN is essential for normal cardiac cholinergic innervation and cholinergic control of heart rate. The presence of residual cardiac cholinergic neurons and vagal bradycardia in KO mice suggests that additional neurotrophic factors may influence this system.
INTERLEUKIN-1 BLOCKADE AMELIORATES LEFT VENTRICULAR REMODELING FOLLOWING ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION - THE VCU-ART PILOT STUDY
Authors: Antonio Abbate, Michael C. Kontos, John Grizzard, Giuseppe GL Biondi-Zoccai, Benjamin W. Van Tassell, Roshanak Robati, Ross Arena, Charlotte Roberts, Amit Varma, Christopher Gelwix, Fadi N. Salloum, Andrea Hastillo, Charles A. Dinarello, George W. Vetrovec
Journal: Journal of the American College of Cardiology (2010)
Abstract 859: CDK11 (PITSLRE) kinase expression is critical for human cancer cell growth and proliferation
Authors: Zhenfeng Duan, Edwin Choy, David Harmon, Henry Mankin, Francis Hornicek
Journal: Cancer Research (2012)

Abstract In the search to identify kinases required for human cancer cell growth, we found CDK11 (PITSLRE) by a comprehensive human kinome-wide shRNA screen to be critical for human cancer cell growth and proliferation. We observed that the expression level of CDK11 was elevated in a variety of human cancer cells and tumor tissues. Furthermore, knock-down of CDK11 either by lentiviral shRNA or by synthetic siRNA inhibits cell growth and induces apoptosis in human cancer cells. In these cells, suppression of CDK11 reduces the expression of several antiapoptotic genes essential for tumor cell survival and proliferation including MCL-1, BcL-XL and survivin. We showed by immunohistochemical analysis that osteosarcoma and ovarian cancer patients with high CDK11 tumor expression levels were associated with significantly shorter survival than patients with lower expression levels of CDK11 expression. Systemic administration of In Vivo Ready siRNA of CDK11 reduced tumor growth in an osteosarcoma s.c. xenograft model. Taken together, these observations suggest that CDK11 signaling is essential in human cancer cell growth and survival. CDK11 may serve as a promising therapeutic target in the treatment of human cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 859. doi:1538-7445.AM2012-859
Appetite suppressants and pulmonary hypertension
Authors: N. F. Voelkel
Journal: Thorax (1997)

Background.Recently in France, primary pulmonary hypertension developed in a cluster of patients exposed to derivatives of fenfluramine in appetite suppressants (anorexic agents), which are used for weight control.We investigated the potential role of anorexic agents and other suspected risk factors for primary pulmonary hypertension.Methods.In a case-control study, we assessed 95 patients with primary pulmonary hypertension from 35 centers in France, Belgium, the United Kingdom, and the Netherlands and 355 controls recruited from general practices and matched to the patients' sex and age.Results.The use of anorexic drugs (mainly derivatives of fenfluramine) was associated with an increased risk of primary pulmonary hypertension (odds ratio with any anorexic-drug use, 6.3; 95 percent confidence interval, 3.0 to 13.2).For the use of anorexic agents in the preceding year, the odds ratio was 10.1 (95 percent confidence interval, 3.4 to 29.9).When anorexic drugs were used for a total of more than three months, the odds ratio was 23.1 (95 percent confidence interval, 6.9 to 77.7).We also confirmed an association with several previously identified risk factors: a family history of pulmonary hypertension, infection with the human immunodeficiency virus, cirrhosis, and use of cocaine or intravenous drugs.Conclusions.The use of anorexic drugs was associated with the development of primary pulmonary hypertension.Active surveillance for this disease should be considered, particularly since the use of anorexic drugs is expected to increase in the near future.
Echocardiographic Features of Endocardial Cushion Defects
Authors: ROBERTA G. WILLIAMS, MICHAEL RUDD
Journal: Circulation (1974)

The echocardiographic features of endocardial cushion defects were defined in 28 patients. Two basic characteristics, common to both complete and incomplete forms of endocardial cushion defects, were found. First, the mitral valve excursion was not seen best in the usual location as defined by intraventricular landmarks. Secondly, the mitral valve echoes in cases where there are dense attachments of the mitral leaflet to the crest of the interventricular septum may be traced to the rightward and anterior border of the left ventricular outflow tract. This is the echocardiographic representation of the characteristic "goose-neck" deformity seen angiographically. Two additional paterns were recognized in patients with complete atrioventricular (A-V) canal. In Pattern I, a large, single, A-V valve was found occupying a central location between the two ventricles. During diastole, the superior segment moved anteriorly into the right ventricle and the inferior segment posteriorly into the left ventricle. In Pattern II, a large single A-V valve moved from the left ventricle in systole into the right ventricle in diastole. This pattern was specific to patients with common A-V valve leaflets.
CARCINOMA IN AN ABERRANT THYROID AT BASE OF TONGUE
Authors: Astley P. C. Ashhurst
Journal: JAMA (1925)

Aberrant thyroid tissue in the tongue is unusual. Carcinoma occurring in such an aberrant thyroid is almost unknown. Bérard and Dunet<sup>1</sup>state that there is not yet on record a proved case of cancer of a lingual thyroid. The following is the history and pathologic report of such a case: <h3>REPORT OF CASE</h3> A. C., a man, aged 56, admitted to the Episcopal Hospital, Nov. 22, 1916, complained of a lump on the back of his tongue near the right lower molar teeth. This lump had been noticed for more than twenty years; first as a small hard mass that very gradually grew larger. After about five years, it began to give him pain. Thirteen years previous to his admission to the Episcopal Hospital (i. e., in 1903), this mass had been removed at the Methodist Hospital, Philadelphia, by Dr. Walter Roberts, who reported to us that it was
Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans
Authors: Ineke den Braber, Tendai Mugwagwa, Nienke Vrisekoop, Liset Westera, Ramona Mögling, Anne Bregje de Boer, Neeltje Willems, Elise H.R. Schrijver, Gerrit Spierenburg, Koos Gaiser, Erik Mul, Sigrid A. Otto, An F.C. Ruiter, Mariette T. Ackermans, Frank Miedema, José A.M. Borghans, Rob J. de Boer, Kiki Tesselaar
Journal: Immunity (2012)
Diseases of the Nose, Pharynx, and Ear.
Authors: Henry Gradle
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The reliability of intermittent ECG sampling in arrhythmia detection.
Authors: L Rydén, A Waldenström, S Homberg
Journal: Circulation (1975)

Although intermittent ECG sampling is a commonly used method for arrhythmia detection there are no controlled studies of its efficiency. In the present study a continuous ECG was recorded for three hours in 52 patients with ventricular tachyarrhythmias. All ECGs were interpreted minute to minute to get the true arrhythmia content. Intermittent ECG samples were simulated by analyzing the first two and first five minutes of every 15 minutes in the ECG material. Two minute long ECG samples were also used every 30 minutes. The 15 and 30 minute long periods were classified as containing arrhythmias or not according to the arrhythmia content of the samples. These findings were subsequently compared with the true arrhythmia content. The arrhythmia detection rate depends on the sampling time and true arrhythmia occurrence. The distribution of arrhythmias within the periods was also of importance. With a five minute long ECG sample about 80% of the intervals containing any type of ventricular tachyarrhythmia will be detected. This is reduced to about 50% when one minute long ECG strips are used. Infrequent types of VPCs such as R on T or ventricular tachycardia are very poorly detected also when sampling as much as one-third of the total time. The study also included a comparison between the results obtained from the clinical material and the results obtained by the use of computerized arrhythmia models. It is concluded that intermittent ECG sampling besides a low detection rate for infrequent arrhythmias and short ECG samples, also brings a risk of underestimating or overemphasizing the arrhythmia occurrence depending on a periodic type of arrhythmia distribution among the patients. These factors make intermittent ECG sampling an unsuitable method for evaluating antiarrhythmic drugs.
MULTIVARIATE ANALYSIS OF PREDICTORS FOR SUCCESSFUL RETROGRADE PROCEDURE IN PERCUTANEOUS CORONARY INTERVENTIONS FOR CHRONIC TOTAL OCCLUSIONS FROM INVESTIGATION FROM JAPANESE RETROGRADE SUMMIT MULTICENTER REGISTRY DATA
Authors: Toshiya Muramatsu, Masahisa Yamane, Makoto Muto, Tsutomu Fujita, Atsunori Okamura, Tetsuo Matsubara, Yasumi Igarashi, Shigeru Nakamura, Mitsunori Abe, Etsuo Tsuchikane, Toshiya Muramatsu
Journal: Journal of the American College of Cardiology (2012)
P1225 THE S282T VARIANT IS NOT OBSERVED IN TREATMENT-NAIVE PATIENTS WITH GENOTYPE 1 HCV INFECTION TREATED WITH THE NUCLEOTIDE INHIBITOR VX-135 IN COMBINATION WITH RIBAVIRIN
Authors: A. Tigges, E. Zhang, A. Davis, J. Spanks, J. Dorrian, J. Symons, D. Bartels, J. Fry, T. Kieffer
Journal: Journal of Hepatology (2014)
Problem of the Deaf Child
Authors: W. H. Davidson
Journal: JAMA (1972)

To the Editor.—  With reference to your lead EDITORIAL on May 22, 1972, Out of the Shadows and the Silence, I agree with Drs. Mindel and McKay, that the physician is ill-prepared to confront the family of a deaf child.  My 10-year-old son had influenzal meningitis at age 2, following which his speech failed to develop and he became a severe behavior problem. After visiting several physicians and two medical centers, we were given several diagnoses: mentally retarded, or emotionally disturbed, or maybe deaf.  After months of being at the end of a rope, my wife and I decided to return our child to our pediatrician who had taken care of our older children when I was a resident in pathology.  After a complete physical examination, it was his view that our son was probably deaf. He suggested that he enter a school for the deaf as soon as possible.
Diabetes-related Mortality in Adults with Cystic Fibrosis. Role of Genotype and Sex
Authors: Connor Lewis, Scott M. Blackman, Amanda Nelson, Ewa Oberdorfer, Daniel Wells, Jordan Dunitz, William Thomas, Antoinette Moran
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

Diabetes is associated with increased mortality in cystic fibrosis. Aggressive screening and early institution of insulin treatment significantly reduced this risk over the period of 1992-2008.To determine if progressive improvement in cystic fibrosis-related diabetes (CFRD) mortality has continued since 2008, and examine associations with CFTR genotypes linked to pancreatic insufficiency and to sex.Chart review was performed on 664 patients followed from 2008 to 2012.Overall mortality for patients with CFRD was 1.8 per 100 person-years, compared with 0.5 in patients with CF without diabetes (P = 0.0002); neither rate changed significantly from mortality reported for 2003-2008. Genotype impacted both mortality and diabetes risk: adults with severe CFTR genotypes experienced greater mortality at every age older than 32 years than those with mild genotypes (P = 0.002), and the risk of developing CFRD was also greatly increased in those with severe genotypes (prevalence 60% in adult patients with severe vs. 14% in adults with mild mutations). CFRD had a direct influence on mortality because it was associated with increased risk of death within each genotype category (20 vs. 2%, P = 0.007 for mild; 12 vs. 4%, P = 0.012 for severe). There was also a sex difference in adults with severe CFTR genotypes; both mortality and CFRD prevalence were higher at every age in females than males.Despite substantial improvement over time, mortality for CFRD patients greater than 30 years remains higher than for patients with CF without diabetes.
Gonorrhea as a Marker of Chlamydial Infection
Authors: Herbert Braunstein
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In the April 17, 1987, issue of<i>JAMA</i>, an article by Washington et al<sup>1</sup>argues for cost-effectiveness of combined ampicillin-tetracycline treatment of endocervical gonorrhea because it will eliminate coinfection with<i>Chlamydia trachomatis</i>. The reasoning of the authors is that gonorrhea is a good marker for chlamydial infection because 26% to 48%<sup>2-4</sup>of female patients with gonorrhea also are infected with<i>Chlamydia</i>. Their argument is correct, as far as it goes, but possesses a fatal flaw. The problem is that the figures cited state a converse relationship to that required to determine the efficacy of gonorrhea as a marker for<i>Chlamydia</i>. The significant figure would be the percentage of individuals with chlamydial infections who also have gonorrhea. <h3>Study.—</h3> In the last two months, we received 577 endocervical smears, studied for both organisms by culture for<i>Neisseria gonorrhoeae</i>and direct fluorescent antibody smear (Syva Microtrak) for<i>Chlamydia</i>
Reducing the carbon footprint of medical conferences
Authors: Ian Roberts, Fiona Godlee
Journal: BMJ (2007)

A striking behavioral abnormality is described in three individuals who had had severe head trauma. At a point when general mnestic capabilities had returned to a near normal level, the patients persistently relocated the hospital at another geographical site, even in the face of compelling counter-evidence. The strong parallels in the etiology and course of the three cases justify the positing of a syndrome, here termed reduplicative paramnesia. A neuropsychologic analysis of the disorder stresses the cognitive operations entailed in geographical localization and confabulation. Clinical-pathologic considerations underline the role of right hemisphere and frontal lobe structures in the syndrome.