tbuckley/cabot-search huggingface dataset:
Effects of Intranasal Administration of Recombinant Murine Interferon-γ on Murine Acute Myocarditis Caused by Encephalomyocarditis Virus
Authors: Norimi Yamamoto, Masafumi Shibamori, Motohiro Ogura, Yoshinori Seko, Mikio Kikuchi
Journal: Circulation (1998)

Background —Viral myocarditis has been strongly implicated in the pathogenesis of dilated cardiomyopathy as well as acute myocarditis. Among the antiviral therapies, interferons (IFNs) have been widely studied and become very important in clinical practice. Methods and Results —To investigate the possibilities of IFN therapy in viral myocarditis, we analyzed the effects of recombinant murine interferon (mIFN)-γ and natural mIFN-α/β by the intranasal and intramuscular routes on the development of acute murine myocarditis caused by encephalomyocarditis virus. Both mIFN-γ and mIFN-α/β treatment by either route significantly increased the survival rate; none of the mIFN-γ–treated mice died. The effect of mIFN-γ was significantly greater than that of mIFN-α/β. Furthermore, intranasal administration of mIFN-γ significantly suppressed virus replication and inflammation in the heart. Conclusions —Our data demonstrate that IFN therapy, especially intranasal administration of IFN-γ, dramatically improved the prognosis of acute murine viral myocarditis by suppressing virus replication and raises the possibility of antiviral therapy with IFN-γ in patients with acute myocarditis.
Inhibition by gold of human lymphocyte stimulation. An in vitro study.
Authors: R B Lies, C Cardin, H E Paulus
Journal: Annals of the Rheumatic Diseases (1977)

Transformation of lymphocytes stimulated by mitogen, purified protein derivative, and in the mixed lymphocyte culture was significantly inhibited by gold sodium thiomate and gold sodium thiosulphate at concentrations of 5 X 10(-4) to 5 X 10(-5) mol/1.
Increased Vascular Endothelial Growth Factor 165 Binding to Kinase Insert Domain–Containing Receptor After Infection of Human Endothelial Cells by Recombinant Adenovirus Encoding the <i>Vegf</i> <sub> <i>165</i> </sub> Gene
Authors: Anat Weisz, Belly Koren, Tzafra Cohen, Gera Neufeld, Tamar Kleinberger, Basil S. Lewis, Moshe Y. Flugelman
Journal: Circulation (2001)

Background —The angiogenic effect of vascular endothelial growth factor (VEGF 165 ) is mediated mainly through the high-affinity tyrosine kinase receptor VEGF-R2 (KDR/ flk-1 ). This study examined the effects of VEGF overexpression by primary human endothelial cells (ECs), which do not express VEGF under physiological conditions, on cell proliferation, VEGF binding to the kinase insert domain–containing receptor (KDR), and KDR expression. Methods and Results —Human primary ECs and SMCs were infected by recombinant adenoviral vector encoding VEGF 165 (rAdVEGF). Proliferation rate, bromodeoxyuridine incorporation, 125 I-labeled VEGF 165 binding to the KDR receptor, and KDR expression were tested in the infected cells and in cells supplemented with VEGF protein. Enhanced proliferation and a significant increase in 125 I-VEGF 165 binding to the KDR receptor were induced by rAdVEGF infection of ECs (autocrine effect) as well as by addition of recombinant VEGF 165 to noninfected cells. Infection of ECs by rAdVEGF led to posttranscriptional upregulation of the KDR receptor, whereas KDR mRNA expression levels remained unchanged. Similar effects were observed with supplemented recombinant VEGF 165 to noninfected ECs; nevertheless, this phenomenon occurred only with high VEGF 165 concentrations (10 ng/mL). Conclusions —The effect of VEGF 165 on proliferation and upregulation of KDR receptor expression demonstrated an autocrine phenomenon of EC sensitization. The fact that high concentrations of VEGF may be achieved in vivo by local continuous overexpression of VEGF 165 by gene transfer emphasizes the potential advantage of gene transfer over protein supplementation for therapeutic angiogenesis.
Computer Searching of the Medical Literature
Authors: PATRICIA K. SMITH
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 May 1986Computer Searching of the Medical LiteraturePATRICIA K. SMITH, M.L.S.PATRICIA K. SMITH, M.L.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-5-723_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The conclusions of Haynes and colleagues (1) in their evaluation of MEDLINE searching systems are not supported by my years of experience as a professional searcher.The ostensible purpose of the study was to evaluate mechanisms for the clinician to access MEDLINE or other online services. The authors correctly assess that most general practitioners are behind in their knowledge of the literature. My experience as both a professional searcher and a patient support this conclusion. Obstetricians routinely suggest a diagnostic test on the basis of data that were superseded several years ago by a definitive study. In...Reference1. HAYNES R, MCKIBBON K, and WALKER C. Computer searching of the medical literature: an evaluation of MEDLINE searching systems. Ann Intern Med. 1985;103:812-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PATRICIA K. SMITH, M.L.S.Affiliations: P.O. Box 140580; Coral Gables, FL 33114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1986Volume 104, Issue 5Page: 723-723KeywordsComputers ePublished: 1 December 2008 Issue Published: 1 May 1986 PDF downloadLoading ...
A Follow-Up Study of Psychiatric Consultations in the General Hospital: What Happens to Patients after Discharge?
Authors: M. Rigatelli, L. Casolari, I. Massari, S. Ferrari
Journal: Psychotherapy and Psychosomatics (2001)

An appropriate follow-up is considered essential in the consultation-liaison psychiatry setting, but it is often neglected. This study evaluated the effectiveness of the psychiatric consultation process in the general hospital, by investigating what occurred to patients 3-5 months after discharge.We used a three-part questionnaire: (1) the results of the consultation process; (2) a telephone interview with patients, and (3) a telephone interview with the patients' primary care physician, to whom the patients were referred after discharge from hospital. We contacted all consecutive, unselected patients referred to psychiatric consultation from January to July 1999. Complete data were available for 119 patients from an initial group of 318.The consultation process was well accepted by patients and useful to general hospital physicians to complete the final diagnosis of the patient when discharged from hospital. In most cases (78.9%), the psychiatric letter was attached to the discharge letter. The second part of the questionnaire indicated that most patients were satisfied with the consultation process. They thought it helped focus their problems and 60% asserted that they felt better after following their psychiatrists' instructions or therapy. The primary care physicians agreed with the diagnostic results of the psychiatric consultation, mainly followed the psychiatrists' advice, and generally expressed positive comments about the consultation-liaison service.Compliance of hospital physicians, patients, and primary care physicians was good. Follow-up studies on outcome of psychiatric consultations are few and further analysis is strongly recommended.
Erythrocyte sequestration and anemia in severe falciparum malaria. Analysis of acute changes in venous hematocrit using a simple mathematical model.
Authors: T M Davis, S Krishna, S Looareesuwan, W Supanaranond, S Pukrittayakamee, K Attatamsoonthorn, N J White
Journal: Journal of Clinical Investigation (1990)

Microvascular erythrocyte sequestration, the characteristic pathological feature of falciparum malaria, was evaluated using a mathematical model in 46 patients with severe infections. From admission radioisotopic circulating red cell volumes and simultaneous venous hematocrits, the model-derived sequestrum hematocrit (mean [95% confidence limits]: 0.70 [0.43-0.97], n = 29) was twice that of peripheral blood (0.33 [0.30-0.36]). Serial reticulocyte and radiolabeled erythrocyte counts indicated that small numbers of cells enter the circulation during initial therapy. The mean fall in hematocrit over 84 h in 26 nontransfused patients conformed to a three-term equation. A first-order decline (t1/2 2.0 h [0.6-3.4]) suggested an average 7.5% plasma volume expansion through rehydration. A zero-order 6.3% (3.1-9.5) fall (t1/2 25.7 h [21.2-30.2]) occurred contemporaneously with a fall in mean parasitemia from 4.5% (3.6-5.4); from these data the model-derived average sequestered erythrocyte volume (4.8% of the admission hematocrit) was similar to the peripheral parasite burden. A second, first-order fall (t1/2 1,047 h [278-1,816]) indicated loss of uninfected erythrocytes with mean lifespan 62 d. Predicted total plasma volume expansion during initial therapy (21.2%) was similar to radioisotopic estimates in 11 patients (17.3% [2.0-33.1]). Application of the model to individual patient data showed wide variations in relative proportions of circulating and sequestered parasitized cells. The model provides evidence of the nature and fate of all parasitized erythrocytes in malaria.
AN UNIDENTIFIED VIRUS PRODUCING ACUTE MENINGITIS AND PNEUMONITIS IN EXPERIMENTAL ANIMALS
Authors: Thomas Francis, T. P. Magill
Journal: The Journal of Experimental Medicine (1938)

An infectious agent is described which belongs apparently to the class of filtrable viruses, but which, on the basis of the evidence at hand, is not to be identified with any virus previously described. The virus has multiple tropisms and is pathogenic for mice, ferrets, and monkeys of both M. rhesus and M. cynomolgos species. Intranasal infection of mice and ferrets causes extensive pneumonic lesions of fatal severity. Intracerebral inoculation of the virus produces in monkeys a lymphocytic choriomeningitis from which the animal recovers, while in mice a rapidly fatal choriomeningitis is produced. Fatal paralysis occurs in a moderate proportion of mice which receive the virus by intraperitoneal or subcutaneous routes, while the remainder become immune to the intracerebral test but not to the intranasal test. Subcutaneous inoculation of mice, monkeys, ferrets, rabbits, and guinea pigs causes local granulomatous induration of the skin with enlargement of the regional lymph nodes. The virus was repeatedly recovered in 1936 from ferrets inoculated with throat washings of patients suffering from an epidemic disease clinically indistinguishable from epidemic influenza. It is impossible, however, to conclude whether the virus is of ferret or human origin. Although possessing many features in common with the virus of lymphocytic choriomeningitis and the virus of lymphogranuloma inguinale, cross immunity tests have failed to yield any evidence that the new agent is immunologically related to either of the aforementioned viruses. For purposes of identification the name virus of acute meningopneumonitis is suggested.
Hyperuricaemia in hypertension: role of alcohol.
Authors: L E Ramsay
Journal: BMJ (1979)

Hyperuricaemia was present in 18 out of 73 men with untreated mild hypertension and was related significantly to alcohol intake, serum aspartate transaminase activity, and obesity. In the whole group the mean serum urate concentration correlated highly significantly with alcohol intake and activities of serum aspartate and alanine transferases but not with ponderal index, serum creatinine concentration, age, or blood pressure. Hypertension and hyperuricaemia are related at least in part through their common association with frequent alcohol use. A serum urate concentration exceeding 0.5 mmol/l (8--4 mg/100 ml) in a man with untreated hypertension is highly suggestive of heavy alcohol consumption. There was no evidence that hyperuricaemia had a deleterious effect on renal function.
A novel anti-Vpre-B antibody identifies immunoglobulin-surrogate receptors on the surface of human pro-B cells.
Authors: E Sanz, A de la Hera
Journal: The Journal of Experimental Medicine (1996)

Vpre-B and lambda 5 genes, respectively, encode V-like and C-like domains of a surrogate immunoglobulin light chain (psi L). Such psi L complex is expressed in early progenitor B (pro-B) cells, before conventional immunoglobulin heavy (microH) and light (L) chains are produced. We raised a wide panel of monoclonal antibodies (mAbs) against soluble recombinant Vpre-B proteins to study early events in human B cell development. One of these antibodies, B-MAD688, labeled surrogate Ig-complexes on the surface of microH- pro-B cell lines and normal bone marrow cells in immunofluorescence assays. Immunoprecipitations using surface-labeled pro-B cells and B-MAD688 mAb indicated that human psi L is associated with high molecular weight components homologous to the surrogate heavy (psi H) chains described in mouse. Using B-MAD688 and SLC2 mAbs, we were able to distinguish between psi H psi L and microH psi L complexes on the surface of human pro-B and later precursor, pre-B, cells. The finding of psi H psi L complexes in mouse and man lead us to hypothesize a role for psi H-containing receptors in B cell development.
Epidemiology, diagnosis and treatment of systemic Candida infection in surgical patients under intensive care
Authors: J. L. Vincent, E. Anaissie, H. Bruining, W. Demajo, M. El-Ebiary, J. Haber, Y. Hiramatsu, G. Nitenberg, P. O. Nyström, D. Pittet, T. Rogers, P. Sandven, G. Sganga, M. D. Schaller, J. Solomkin
Journal: Intensive Care Medicine (1998)
On street addresses and middle names: my struggle to upload a scientific paper
Authors: Rita Giacaman
Journal: BMJ (2006)

R ecently I set out to upload an article for possible publication in one of the world's main medical journals, the website of which reported its upload system as offering several benefits to authors. To begin positively, I could in fact find listed in the website's menu of countries the country I live in (Occupied Palestinian Territory (OPT), the formal UN designated name for the country since 1967). This was heartening, as until recently I and fellow authors had had to argue with journal editors and publishers for the inclusion of OPT on journals' country menus. I felt quite indignant about this, as many other Palestinians would, as the absence of our country's name implies that we do not exist. But then proofs would come back with “Israel” on them—even after we emailed to correct them—a designation that would have pleased neither side of the Israel-Palestine divide. We experienced this repeatedly, and uploading papers became an uphill struggle.

> Inclusion means creating websites that take into account different cultures, ways of life, and contexts 

Although cheered by the early stages of this latest upload attempt, I kept trying to indicate that our country was the OPT, yet somehow Panama would appear in the address, in between sudden interruptions to the internet connection (a …
Gastroscopic Cytology in Intestinal Metaplasia
Authors: A. Perez-Mota, A. Casanova, A. Hidalgo
Journal: Endoscopy (1977)

Based on the findings of goblet cells the authors established cytologic criteria for the diagnosis of intestinal metaplasia. With this technique they made the diagnosis of intestinal metaplasia in 79.4% of the cases surgically confirmed, this contrast to endoscopic biopsy with only 35.2%. on the other hand, the cytologic diagnosis of malignancy is obtained in the same series in 92% of 25 gastric cancers against 80% of endoscopic biopsy. Among the controls surgically verified there was no cytologic false positive neither for malignancy nor for the diagnosis of intestinal metaplasia. The authors believe that any case with signs of malignancy and intestinal metaplasia may have a better preoperative prognosis.
Intravenous Infusion of Bone Marrow in Patients Receiving Radiation and Chemotherapy
Authors: E. Donnall Thomas, Harry L. Lochte, Wan Ching Lu, Joseph W. Ferrebee
Journal: New England Journal of Medicine (1957)

AFTER a lethal dose of radiation in rodents,1 canines2 or primates,3 the destroyed bone marrow may be repopulated by intravenous infusion of cellular suspensions of marrow taken from healthy isologous, homologous4 and, in some cases, heterologous3 donors. Effective cells for these infusions may be stored by the Polge technic of freezing to -80°C. in glycerol.6 Hosts seeded with donor marrow have some of the immunologic characteristics of the donors, and in some circumstances will take and hold homografts of other organs from them.7 Since cases of radiation disaster may occur, and since bone-marrow deficiency from radiation or chemotherapy does occur . . .
A CASE OF RETROPERITONEAL FIBROLIPOMA.
Authors: GEORGE BEN JOHNSTON
Journal: JAMA (1904)

The following case of a retroperitoneal fibrolipoma is so typical of this rare form of abdominal tumor, at the present time receiving in general but indefinite recognition and differentiation, that it seems to justify a detailed presentation. On account of the necessity for anticipating the malignant degeneration to which all such connective tissue tumors are more or less prone, as well as preventing the serious involvement of various organs even by a benign overgrowth, an early diagnosis is of great importance. This, in view of the frequent paucity of symptoms and obscure local signs, is difficult and but infrequently made before the condition has rendered an operation impossible or extremely hazardous. In 1897 Adami<sup>1</sup>gave the immediate mortality from operation of the twenty-six instances he was able to collect at 53.9 per cent. One recurrence increased the mortality to 57.7 per cent. I have collected in addition to these three
Effect of hypothermia on lung compliance
Authors: C. W. Deal, J. C. Warden, I. Monk
Journal: Thorax (1970)

The changes in pulmonary compliance have been studied under conditions of total body hypothermia. Five groups of sheep were used; two groups were controls—one for the effects of anaesthesia and the other for normothermic biventricular bypass. The third group was cooled using a femoro-femoral arterio-venous shunt to 20°-23° C. The fourth group was cooled to 15° C. and rewarmed using the Drew technique. The excised lungs of the remaining sheep were studied at 37° and 15° C. (fifth group). The controls showed little change in compliance. The cooled animals showed a decrease in compliance. In the group subjected to hypothermia by the Drew technique, the rewarming phase initially brought a return towards normal compliance. As the temperature rose to 24°-30° C. the improvement in compliance ceased and thereafter compliance decreased for two hours after rewarming. Histologically the lungs were normal. There was no compliance change caused by cooling the excised lungs.
Paroxysmal Atrial Fibrillation in a Physically Active Man
Authors: Paul D. Thompson
Journal: JAMA (1988)

<h3>To the Editor.—</h3> Dr Dunn<sup>1</sup>raised the possibility of atrioventricular nodal dysfunction in a 63-year-old wind-surfer whose ventricular response to atrial fibrillation was only 80 beats per minute. An additional explanation for the slow ventricular response is enhanced vagal tone, a common physiological effect of exercise training. Our clinical experience suggests that a slow ventricular response to atrial fibrillation is the rule rather than the exception in such endurance-trained patients.
1119 A FUNCTIONAL VARIANT IN FC RECEPTOR-LIKE 3 (FCRL3) GENE IS ASSOCIATED WITH SUSCEPTIBILITY OF PRIMARY BILIARY CIRRHOSIS IN JAPANESE, BUT NOT IN ITALIAN
Authors: A. Tanaka, H. Ohira, K. Kikuchi, A. Shibuya, S. Nezu, P. Invernizzi, H. Takikawa
Journal: Journal of Hepatology (2010)
DISEASES OF THE GALL BLADDER AND BILE DUCTS IN RELATION TO DISEASES OF THE GASTROINTESTINAL TRACT.
Authors: BERTRAM W. SIPPY
Journal: JAMA (1904)

Owing to the close anatomic proximity of the gall bladder and bile ducts to certain portions of the gastrointestinal tract, disease of one of these structures may be readily transmitted to the other. The symptoms arising from disease of these parts are often hopelessly confused, as illustrated by the difficulty at times in differentiating cholelithiasis and gastric ulcer. No wonder, for, as Fleiner states in effect, one may well say gallstone disease may not only simulate all of the diseases of the gastrointestinal tract, but it may produce them, namely, stomach cramp, intestinal colic, vomiting, diarrhea, bloody vomit, bloody stools, symptoms of ulcer, actual ulceration, tumor, stenosis of the pylorus, duodenum and colon, gastric hypersecretion and tetany. The disorders of the stomach and intestine arising from disease of the gall bladder and bile ducts may be conveniently divided into those nervous or reflex in origin, and those due to a direct extension of the anatomic disease.
PROPHYLACTIC VACCINATION AGAINST EPIDEMIC MENINGITIS
Authors: J. H. BLACK
Journal: JAMA (1913)

which xvas closely adherent to the bone.X-ray shoxved absence of about G cm. of the loxver end of the fibula. 1 exposed the upper end of the fibula and split it longitudinally so Hint about one-third of the cpiphysis xvith its cartilage was removed, together xvith a portion of tho shaft xvith its periosteum', C> cm. in length.This xvas transplanted into the defect below, the graft being secured to tho freshened stump of the lihiila by a collar of free fascia, and the opipliysenl end fastened snugly to the astragalus by a free fascia bund.In spile of unfavorable conditions on account of poor blood-supply this graft has done xvell.Skiagrams from time to time have shown the opiphyseal line to be present.Dr. Baetjer reported to me last week that ¡in a'-ruy taken then shoxved the epiphyseal line still intact and that the bone xvas undoubtedly growing.Tliis result is, to say the least, encouraging.Du. Funu 11.Auuîiï, New York: My experience xvith the transplantation of tissues has been confined wholly to bone, about thirty-six cases.All the transplants have been auto- transplants, and the xx'ork xx-as all done from the point of vlexv of an orthopedic surgeon.There xvere cases of congenital defects in the bony skeleton, pseudo-arthrnscs, club-feet, etc., and I believe that in tlie latter class of cases this is the ideal treatment.We can reconstruct tho skeleton of the foot com- pletely by using bone wedges, thus securing a properly shaped foot.The use I have made of bone transplantation has been mostly in Pott's disease.I believe that this xvill be eventually the accepted treatment, und the earlier the operation is done the better.I have kept in storage recently infants' bones to be used for bone-grafting.Auto-transplantation is better, but there xvill be certain cases in which it is better to use some other bone, and not to subject the patient to the extra hazard of taking some of bis bone.My xvork in animal experimentation has been cruder tliiin Dr. Carrel's, but I have been able to preserve dogs' bones for four days in an ordinary isotonic Ringer's solution.I have transplanted this bone and it has lived and groxvn.In the ice-box, of course, die temperature is far above that of cold storage, showing that xve have considerable leeway» in the handling of bone.Dit. A. Carrel, New York: I agree xvith xvhnt Dr, Davis and Dr. Albee said in regard to transplantation.It is cer- tain that the question of the usefulness of transplantation of tissue has not been settled.Auto-transplantation giyes better results than iso-transplantation, and it is only by making nexv investigations that it xvill be possible to know the value of homo-transplantation, especially if the tissues are taken fron) small children.That question cannot be very easily decided hy skin-grafting.My experiments are too fexv in number to enable mo to come to any definite conclusion.Many other experiments should be made.