Barrett Esophagus after Chemotherapy with Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF): An Iatrogenic Injury?
Authors: Sergio Sartori, Ingrid Nielsen, Monica Indelli, Lucio Trevisani, Paolo Pazzi, Enrico Grandi
Journal: Annals of Internal Medicine (1991)

Brief Reports1 February 1991Barrett Esophagus after Chemotherapy with Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF): An Iatrogenic Injury?Sergio Sartori, MD, Ingrid Nielsen, MD, Monica Indelli, MD, Lucio Trevisani, MD, Paolo Pazzi, MD, Enrico Grandi, MDSergio Sartori, MD, Ingrid Nielsen, MD, Monica Indelli, MD, Lucio Trevisani, MD, Paolo Pazzi, MD, Enrico Grandi, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-3-210 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn Barrett esophagus, the squamous mucosa of the lower esophagus is replaced by columnar epithelium (1). This metaplastic disorder can result from a congenital abnormality, but more frequently results from gastroesophageal reflux (1, 2).In 1987, Dahms and colleagues (3) observed Barrett esophagus in three children who had been treated with antileukemia chemotherapy and suspected that Barrett esophagus could result from chemotherapy-induced esophageal mucosal injury. We recently reported six cases of Barrett esophagus in eight women who had been treated with several courses of chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) for breast cancer (Sartori S. Communication at "The Holland...References1. SpechlerGoyal SR. Barrett's esophagus. N Engl J Med. 1986; 315:362-71. CrossrefMedlineGoogle Scholar2. SavaryMonnier MP. Diagnosis, pathophysiology and adenocarcinogenesis of Barrett's esophagus. In: De Meester TR, Skinner DB, eds. Esophageal Disorders. New York: Raven Press; 1985:101-19. Google Scholar3. DahmsGrecoStrandjordRothstein BMSF. Barrett's esophagus in three children after antileukemia chemotherapy. Cancer. 1987;60:2896-900. CrossrefMedlineGoogle Scholar4. McClaveBoyceGottfried SHM. Early diagnosis of columnarlined esophagus: a new endoscopic diagnostic criterion. Gastrointest Endosc. 1987;33:413-6. CrossrefMedlineGoogle Scholar5. TytgatHameetemanOnstenkSchotborg GWRR. The spectrum of columnar-lined esophagus—Barrett's esophagus. Endoscopy. 1989;21:177-85. CrossrefMedlineGoogle Scholar6. AdrianHoodSkarin RAA. Mucocutaneous reactions to antineoplastic agents. CA. 1980;30:143-56. Google Scholar7. Lewis J. Gastrointestinal injury due to medicinal agents. Am J Gastroenterol. 1986;81:819-32. MedlineGoogle Scholar8. SartoriNielsenPazziTrevisani SIPL. Barrett's esophagus caused by antineoplastic chemotherapy: a case-report [Abstract]. Hepatogastroenterology. 1989;36:304. Google Scholar9. RotheryPattersonStoddardDay GJCD. Histological and histochemical changes in the columnar lined (Barrett's) esophagus. Gut. 1986;27:1062-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sergio Sartori, MD; Ingrid Nielsen, MD; Monica Indelli, MD; Lucio Trevisani, MD; Paolo Pazzi, MD; Enrico Grandi, MDAffiliations: From St. Anna General Hospital and the Ferrara University School of Medicine, Ferrara, Italy. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociation of sporadic and familial Barrett's esophagus with breast cancerDefinition, Derivation, and Diagnosis of Barrett's Esophagus: Pathological PerspectivesPersonal and family history of cancer and the risk of Barrett's esophagus in menBarrett's esophagus: A historical perspective, an update on core practicalities and predictions on future evolutions of managementExposure to Both Radiation and Chemotherapy Increases the Risk of Barrett's and Multilayered EpitheliumGastrointestinal Bleeding in the Cancer PatientBIOLOGY AND EPIDEMIOLOGY OF MALIGNANT ESOPHAGEAL CARCINOMAImpact of radiotherapy in the risk of esophageal cancer as subsequent primary cancer after breast cancerPathogenesis of columnar-lined esophagusEpidemiology and Molecular Biology of Barrett EsophagusGastroesophageal Reflux and Barrett's EsophagusSecond Malignant Neoplasms Among Long-Term Survivors of Hodgkin's Disease: A Population-Based Evaluation Over 25 YearsRole of molecular biology in the follow-up of patients who have Barrett's esophagusExfoliative Esophagitis Early After Autologous Peripheral Blood Stem Cell TransplantationAblación endoscópica del epitelio de BarrettGASTROESOPHAGEAL REFLUX DISEASE AND BARRETT'S ESOPHAGUSSecond Cancers Among Long-Term Survivors of Hodgkin's Disease Diagnosed in Childhood and AdolescenceComplete regression of Barrett's esophagus with heat probe thermocoagulation: mid-term resultsEsophageal Manometry and Ambulatory 24-Hour pH Monitoring in Patients With Short and Long Segment Barrett's EsophagusCOLUMNAR-LINED ESOPHAGUS IN CHILDRENCo-Morbidities in Childhood Barrett's EsophagusEpidemiology and molecular biology of Barrett's adenocarcinomaEsophageal manifestations of rheumatic disordersEsophageal Malignancy after Liver Transplantation in a Patient with Barrett's EsophagusBarrett's EsophagusControversies in the management of adenocarcinoma of the esophagus and esophagogastric junctionSucrase-isomaltase gene expression in Barrett's esophagus and adenocarcinomaBarrett's oesophagus-cancer risk, biology and therapeutic managementBarrett's esophagus: Pathogenesis, epidemiology, functional abnormalities, malignant degeneration, and surgical managementRestoration of squamous mucosa after ablation of Barrett's esophageal epitheliumIs chemotherapy associated with development of Barrett's esophagus?Existe-t-il un traitement médical de l'œsophage de Barrett?Regression of Barrett's esophagus by laser ablation in an anacid environmentBarrett's Oesophagus and CarcinomaBarrett's esophagus: lack of association with adjuvant chemotherapy for localized breast carcinomaEndoscopic Assessment of Premalignant Esophageal DisordersThe Etiology and Prevention of Aerodigestive Tract CancersCytostatics and immunosuppressive drugsBarrett's EsophagusBarrett EsophagusN. Mullai, MD, Kulumani M. Sivarajan, MD, Gail Shiomoto, MDNewsBarrett Esophagus: A Sequela of ChemotherapyStuart Jon Spechler, MD 1 February 1991Volume 114, Issue 3Page: 210-211KeywordsChemotherapyCongenital disordersCyclophosphamideEpitheliumEsophagusGastroesophageal reflux diseaseHematology and oncologyHospital medicineMethotrexateMucous membranes ePublished: 1 December 2008 Issue Published: 1 February 1991 PDF downloadLoading ...