Treatment of Early Lyme Disease
Authors: Gary P. Wormser, John Nowakowski, Robert B. Nadelman
Journal: Annals of Internal Medicine (2004)

Letters6 April 2004Treatment of Early Lyme DiseaseGary P. Wormser, MD, John Nowakowski, MD, and Robert B. Nadelman, MDGary P. Wormser, MDFrom New York Medical College, Valhalla, NY 10595.Search for more papers by this author, John Nowakowski, MDFrom New York Medical College, Valhalla, NY 10595.Search for more papers by this author, and Robert B. Nadelman, MDFrom New York Medical College, Valhalla, NY 10595.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-7-200404060-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Stricker and colleagues have “creatively” misread our study, in which 10 days and 20 days of doxycycline treatment were demonstrated to have similar efficacy in patients with erythema migrans. Efficacy was evaluated at 4 different, specific time points (20 days, 3 months, 12 months, and 30 months), as well as at the time of the last visit with the patient, in both an on-study and an intention-to-treat analysis. The sample size estimates were based, as explicitly stated in the manuscript, on the 12-month time point, and were met.At last patient contact in our intention-to-treat analysis, the complete ...References1. Nowakowski J, Nadelman RB, Sell R, McKenna D, Cavaliere LF, Holmgren D, et al . Long-term follow-up of patients with culture-confirmed Lyme disease. Am J Med. 2003;115:91-6. [PMID: 12893393] CrossrefMedlineGoogle Scholar2. Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig E, Schoen RT, et al . Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. N Engl J Med. 1998;339:209-15. [PMID: 9673298] CrossrefMedlineGoogle Scholar3. Wormser GP, Nadelman RB, Dattwyler RJ, Dennis DT, Shapiro ED, Steere AC, et al . Practice guidelines for the treatment of Lyme disease. The Infectious Diseases Society of America. Clin Infect Dis. 2000;31 Suppl 1 1-14. [PMID: 10982743] CrossrefMedlineGoogle Scholar4. Klempner MS, Hu LT, Evans J, Schmid CH, Johnson GM, Trevino RP, et al . Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med. 2001;345:85-92. [PMID: 11450676] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Gary P. Wormser, MD; John Nowakowski, MD; Robert B. Nadelman, MDAffiliations: From New York Medical College, Valhalla, NY 10595. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDuration of Antibiotic Therapy for Early Lyme Disease Gary P. Wormser , Roshan Ramanathan , John Nowakowski , Donna McKenna , Diane Holmgren , Paul Visintainer , Rhea Dornbush , Brij Singh , and Robert B. Nadelman Treatment of Early Lyme Disease Raphael B. Stricker , Andrea Gaito , Nick S. Harris , and Joseph J. Burrascano Metrics Cited byGeneralizability in two clinical trials of Lyme diseaseEvaluation of Tests for Lyme Disease 6 April 2004Volume 140, Issue 7Page: 577-578KeywordsAntibioticsArthralgiaBacteriaDoxycyclineErythemaFatigueInfectious diseasesIntent to treat analysisLyme diseaseTicks ePublished: 6 April 2004 Issue Published: 6 April 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...