tbuckley/cabot-search huggingface dataset:
Treatment of Brain Arteriovenous Malformations
Authors: Janneke van Beijnum, H. Bart van der Worp, Dennis R. Buis, Rustam Al-Shahi Salman, L. Jaap Kappelle, Gabriël J. E. Rinkel, Jan Willem Berkelbach van der Sprenkel, W. Peter Vandertop, Ale Algra, Catharina J. M. Klijn
Journal: JAMA (2011)

<h3>Context</h3> Outcomes following treatment of brain arteriovenous malformations (AVMs) with microsurgery, embolization, stereotactic radiosurgery (SRS), or combinations vary greatly between studies. <h3>Objectives</h3> To assess rates of case fatality, long-term risk of hemorrhage, complications, and successful obliteration of brain AVMs after interventional treatment and to assess determinants of these outcomes. <h3>Data Sources</h3> We searched PubMed and EMBASE to March 1, 2011, and hand-searched 6 journals from January 2000 until March 2011. <h3>Study Selection and Data Extraction</h3> We identified studies fulfilling predefined inclusion criteria. We used Poisson regression analyses to explore associations of patient and study characteristics with case fatality, complications, long-term risk of hemorrhage, and successful brain AVM obliteration. <h3>Data Synthesis</h3> We identified 137 observational studies including 142 cohorts, totaling 13 698 patients and 46 314 patient-years of follow-up. Case fatality was 0.68 (95% CI, 0.61-0.76) per 100 person-years overall, 1.1 (95% CI, 0.87-1.3; n = 2549) after microsurgery, 0.50 (95% CI, 0.43-0.58; n = 9436) after SRS, and 0.96 (95% CI, 0.67-1.4; n = 1019) after embolization. Intracranial hemorrhage rates were 1.4 (95% CI, 1.3-1.5) per 100 person-years overall, 0.18 (95% CI, 0.10-0.30) after microsurgery, 1.7 (95% CI, 1.5-1.8) after SRS, and 1.7 (95% CI, 1.3-2.3) after embolization. More recent studies were associated with lower case-fatality rates (rate ratio [RR], 0.972; 95% CI, 0.955-0.989) but increased rates of hemorrhage (RR, 1.02; 95% CI, 1.00-1.03). Male sex (RR, 0.964; 95% CI, 0.945-0.984), small brain AVMs (RR, 0.988; 95% CI, 0.981-0.995), and those with strictly deep venous drainage (RR, 0.975; 95% CI, 0.960-0.990) were associated with lower case fatality. Lower hemorrhage rates were associated with male sex (RR, 0.976, 95% CI, 0.964-0.988), small brain AVMs (RR, 0.988, 95% CI, 0.980-0.996), and brain AVMs with deep venous drainage (0.982, 95% CI, 0.969-0.996). Complications leading to permanent neurological deficits or death occurred in a median 7.4% (range, 0%-40%) of patients after microsurgery, 5.1% (range, 0%-21%) after SRS, and 6.6% (range, 0%-28%) after embolization. Successful brain AVM obliteration was achieved in 96% (range, 0%-100%) of patients after microsurgery, 38% (range, 0%-75%) after SRS, and 13% (range, 0%-94%) after embolization. <h3>Conclusions</h3> Although case fatality after treatment has decreased over time, treatment of brain AVM remains associated with considerable risks and incomplete efficacy. Randomized controlled trials comparing different treatment modalities appear justified.
Psychological Diagnosis of Intracranial Pathology after Accident
Authors: Alice Friedman
Journal: Psychotherapy and Psychosomatics (1956)

Research Articles| February 10 2010 Psychological Diagnosis of Intracranial Pathology after Accident Subject Area: Psychiatry and Psychology Alice Friedman Alice Friedman New York Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1956) 4 (4): 352–357. https://doi.org/10.1159/000285263 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Alice Friedman; Psychological Diagnosis of Intracranial Pathology after Accident. Acta Psychotherapeutica et Psychosomatica 1 April 1956; 4 (4): 352–357. https://doi.org/10.1159/000285263 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1956Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Global aid programmes are failing the worlds poorest people
Authors: C. McKenna
Journal: BMJ (2002)

John Simpson, BBC world affairs editor and patron of the charity Health Unlimited, has told an audience that global aid programmes have prioritised populations that are more accessible, rather than the most needy people, in order to meet targets.

Speaking at the Royal College of Physicians last week, Mr Simpson referred to the “broken promises” of the world's richest governments. He spoke of the millennium development goals on poverty reduction and access to education, water, and …
THE EFFICACY AND SAFETY OF TICAGRELOR AS COMPARED TO CLOPIDOGREL, WITH AND WITHOUT A GLYCOPROTEIN IIB/IIIA INHIBITOR IN PATIENTS WITH ACUTE CORONARY SYNDROMES UNDERGOING PERCUTANEOUS INTERVENTION: A PLATO (STUDY OF PLATELET INHIBITION AND PATIENT OUTCOMES) ANALYSIS
Authors: Sameer Bansilal, Stephen Wiviott, Richard Becker, Robert Harrington, Anders Himmelmann, Benjamin Neely, Steen Husted, Robert Storey, Philippe Steg, Hugo Katus, Stefan James, Lars Wallentin, Christopher Cannon
Journal: Journal of the American College of Cardiology (2013)
Injuries to the Eye in Their Medico-Legal Aspect
Authors: S. Baudry
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Making Rational Treatment Decisions in Rheumatoid Arthritis When Methotrexate Fails
Authors: Joan M. Bathon, Donald J. McMahon
Journal: New England Journal of Medicine (2013)

Advances in the treatment of rheumatoid arthritis in recent years have profoundly muted the destructive potential of this disease. The safety profile of methotrexate has made earlier treatment possible, and biologic therapies have opened the door to combination rather than sequential therapy, with the result that treatment recommendations now aim for disease remission.1,2 However, the evidence base guiding the treatment that should be given after a patient has an inadequate response to methotrexate monotherapy is weak, despite the armamentarium of efficacious agents.O'Dell et al. now report in the Journal the results of their randomized clinical trial evaluating the . . .
Direct Comparison of Insulin Lispro and Aspart Shows Small Differences in Plasma Insulin Profiles After Subcutaneous Injection in Type 1 Diabetes
Authors: Christina A. Hedman, Torbjörn Lindström, Hans J. Arnqvist
Journal: Diabetes Care (2001)

Two rapid-acting insulin analogs, lispro and aspart, are now available for clinical use (1).

The aim of our study was to compare the plasma-insulin profiles of these analogs after subcutaneous injection in patients with type 1 diabetes.

Fourteen patients with type 1 diabetes (six men and eight women, [mean ± SEM] 35.4 ± 3.3 years of age [range 22–59], HbA1c 7.3 ± 0.3% [reference range 3.2–5.4], BMI 24.7 ± 1.1 kg/m2, and diabetes duration 22.9 ± 2.6 years) were recruited for the study. Only two patients had measurable C-peptide levels (0.04 and 0.11 nmol/l). All patients were on multiple-injection therapy with a breakfast insulin dose of 11.1 ± 0.7 U (range 6–14) and no intermediate-acting insulin in the morning.

The study was designed as a single blind randomized crossover study. On the first day, seven patients were randomized to insulin lispro (Humalog, U-100; Eli Lilly, Indianapolis, IN), and the other seven were randomized to insulin aspart (NovoRapid, U-100; Novo-Nordisk, Bagsveard, Denmark). On the second study day (5–21 days later), the patients received the alternative insulin analog. The patients continued their usual insulin treatment between the study days.

All patients arrived to the clinic fasting. After an initial blood sampling, they were given 10 U s.c. of one of the insulins in the abdominal wall at 7:30 a.m. A standardized breakfast, which had an energy content of 418 kcal and a nutrient content of 21 g protein, 11 g …
Research council failed to clearly communicate its open access policy, say peers
Authors: S. Mayor
Journal: BMJ (2013)

The House of Lords Science and Technology Committee has criticised Research Councils UK (RCUK) for failures in communicating its policy on open access. In a report published on 22 February the peers recommended that RCUK clarify its guidance, communicate it more clearly, and monitor implementation.1

RCUK’s policy on open access is to make peer reviewed journal articles resulting from work funded by its councils available online at no cost to readers.2 The House of Lords committee, which scrutinises government policy on science and technology, carried out an inquiry into the policy after researchers and publishers raised concerns about a lack of clarity, limitations on academic freedom to publish, funding for publication fees, and the speed of the transition to …
Risk factors for recurrent bile duct stones after endoscopic papillotomy
Authors: T Ando
Journal: Gut (2002)

The long term outcome of endoscopic papillotomy (EPT) is not well known. The aims of this study were to clarify the clinical course of post-EPT patients and to detect predictors for bile duct stone recurrence.A total of 1042 consecutive patients who underwent EPT for bile duct stones from December 1975 to September 1998 were prospectively followed up. Patients were divided into four groups according to gall bladder (GB) status: "acalculous GB" group, "calculous GB" group, "cholecystectomy" group, and "prior cholecystectomy" group. Reliable follow up information was obtained for 983 (94.3%) of the 1042 patients. The following factors were considered in the evaluation of predisposing risk factors for recurrence of bile duct stones: age, sex, gall bladder status, periampullary diverticulum, number of bile duct stones, diameter of bile duct stones, diameter of bile duct, lithotripsy, precutting, pneumobilia, and early complications.Recurrence occurred in 111 patients. The "acalculous GB" group was less prone to recurrence than the "prior cholecystectomy" group and the "calculous GB" group. The relative risks (RR) for the latter two compared with the former group were 2.26 (95% confidence interval (CI) 1.24-4.14; p=0.0078) and 2.16 (95% CI 1.21-3.87; p=0.0093), respectively. Other prognostic factors were lithotripsy (RR 2.37; 95% CI 1.47-3.81; p=0.0004) and pneumobilia (RR 1.57; 95% CI 1.01-2.43; p=0.044).Gall bladder status, lithotripsy, and pneumobilia were significantly related to bile duct stone recurrence after EPT.
Pseudomembranous invasive tracheobronchial aspergillosis
Authors: J Franco
Journal: Thorax (2004)

Invasive aspergillus tracheobronchitis is a rare infectious complication in severely immunocompromised patients who are generally neutropenic with haematological diseases, AIDS, or after solid organ transplantation. However, a few cases have been reported with no apparent severe compromise in the host defences.1 Aspergillus tracheobronchitis varies from localised tracheobronchitis …
The interaction of alpha 1-proteinase inhibitor and tissue kallikrein in controlling allergic ovine airway hyperresponsiveness.
Authors: R Forteza, Y Botvinnikova, A Ahmed, A Cortes, R H Gundel, A Wanner, W M Abraham
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We reported previously that the development of airway hyperresponsiveness (AHR) 24 h after antigen challenge in allergic sheep was associated with increased tissue kallikrein activity (TK) and decreased alpha-1-proteinase inhibitor (alpha 1-PI) activity in bronchoalveolar fluid (BAL). The inverse correlation between TK and alpha 1-PI in these experiments suggested that administration of alpha 1-PI might reduce TK activity and block AHR. To test this hypothesis, airway responsiveness, as determined by calculating the cumulative carbachol breath units (BU) that increased specific lung resistance by 400% (PC400), was measured before and 24 h after aerosol challenge with Ascaris suum antigen in seven sheep hypersensitive to this antigen. On the next day, 30 min before the 24 h PC400 measurement, the sheep were treated with either aerosol alpha 1-PI (Prolastin, 10 mg/5 ml) or denatured (DN) prolastin (10 mg/5 ml), which had only 10% of its original activity. BAL was also performed before and 24 h after challenge for the measurement of TK and alpha 1-PI activity. Treatment with DN-Prolastin at 24 h after antigen challenge did not block antigen-induced AHR: PC400 fell from a baseline (mean +/- SE) of 26.0 +/- 3.2 BU to 11.2 +/- 1.5 BU after challenge (p < 0.05). This AHR was associated with increased TK (363%, p < 0.05) and decreased alpha 1-PI activity (65%, p < 0.05). Prolastin treatment at 24 h blocked the AHR: PC400 was 21.0 +/- 2.8 before and 23.2 +/- 3.7 after challenge (p < 0.05 versus DN-Prolastin) and the changes in BAL TK (28% increase) and alpha 1-PI activities (15% increase) were not different from baseline (both p < 0.05 versus DN-Prolastin). There was a significant inverse correlation between alpha 1-PI activity and TK activity in BAL, as well as the changes between baseline and 24 h in alpha 1-PI activity and TK activity in BAL Pretreatment (30 min before antigen challenge) with Prolastin also protected against the antigen-induced AHR. The effect of Prolastin was also seen against aerosol challenge with high-molecular-weight kininogen (HMWK), a substrate of TK. HMWK caused bronchoconstriction which was blocked by Prolastin (p < 0.05), and the bradykinin B2 antagonist, NPC-567 (indicating that kinins were generated), but not DN-Prolastin or the elastase inhibitor, ICI 200, 355. Although the negative association between alpha 1-PI activity and TK activity identified in this study does not prove cause and effect, our findings do raise the possibility that in vivo alpha 1-PI may regulate TK activity and allergen-induced AHR.
The similarity between ventricular pressure-volume relation and muscle force-length relation
Authors: K. SAGAWA, W L. MAUGHAN, D. BURKHOFF, D. YUE
Journal: Cardiovascular Research (1985)

Journal Article The similarity between ventricular pressure-volume relation and muscle force-length relation Get access KIICHI SAGAWA, KIICHI SAGAWA From the Department of Biomedical Engineering, Johns Hopkins University Medical School, Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar W LOWELL MAUGHAN, W LOWELL MAUGHAN From the Department of Biomedical Engineering, Johns Hopkins University Medical School, Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar DANIEL BURKHOFF, DANIEL BURKHOFF From the Department of Biomedical Engineering, Johns Hopkins University Medical School, Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar DAVID YUE DAVID YUE From the Department of Biomedical Engineering, Johns Hopkins University Medical School, Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 19, Issue 9, September 1985, Page 523, https://doi.org/10.1093/cvr/19.9.523 Published: 01 September 1985
Magnetic resonance imaging of the knee: direct access for general practitioners
Authors: R Watura, D. C F Lloyd, S Chawda
Journal: BMJ (1995)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Magnetic resonance imaging of the knee: direct access for general practitioners Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Referrals between consultants: Consultant referrals are funded
Authors: Tim E P Davies
Journal: BMJ (2006)

Case reports of suspected adverse drug reactions Case reports were dismissed too quicklyEditor-The main difference between the replications by Loke et al of Venning's studies from the 1980s and the original is the evidence that is accepted as further follow-up. 1 Loke et al mention that 56 of 63 case reports on adverse reactions were cited at least once but accept only nine instances as valid follow-up: attempts at proof of mechanisms or controlled studies.However, unexpected adverse effects are by definition due to an unknown mechanism, and many established adverse effects still escape elucidation after years.Moreover, further accumulation of anecdotal reports can be sufficient evidence.A 10 year tally of 22 drugs that were withdrawn from the market showed that 18 were prompted by case reports and only four by a controlled study; for at least 13 the case reports proved sufficient reason for withdrawal. 2 A highly unusual event that is repeatedly reported in a recently marketed drug, in the absence of publicity, points to an exceedingly high relative risk, a good argument for cause and effect. 3 Moreover, these risks will be picked up spontaneously. 4 5 Apart from the nine instances of follow-up that were accepted by Loke et al, 15 datasheets were amended and seven BNP drug monographs changed.So, even with some overlap, close to half of the case reports were somehow sufficiently noteworthy to have had consequences.Given the small sample size, this is not far from Venning's original.It is a pity that Loke et al do not make all follow-up more explicit for all 56 instances that followed the 63 reports.Their overall conclusion that lack of follow-up means that case reports are of limited value is a non-sequitur.It shows that a more consistent scheme of hypothesistesting studies by industry, government, or third parties is needed instead of the current haphazard approach to drug safety.Such publications may alert and help clinicians in recognising potential adverse events in their patients.Often there is no other way of discovering something unusual.The record of systematic-that is, controlledpostmarketing surveillance in detecting unexpected adverse effects remains surprisingly poor.
Endoscopic Drainage of Pancreatic Pseudocysts Guided by Endosonography
Authors: R. Gerolami, M. Giovannini, R. Laugier
Journal: Endoscopy (1997)

Endoscopic drainage of cysts is now accepted as an effective treatment in chronic pancreatitis. Endosonography is coming to be regarded as essential before endoscopic therapy, since it can precisely identify the best and safest point at which to perform the cystoenterostomy. The present report illustrates from four cases that, in some patients, endosonography may contraindicate endoscopic drainage, while in others, it can prove the feasibility of the treatment even when there is no bulging of the cyst into the digestive tract.
Letter Regarding Article by Bokhari et al, “Long-Term Comparison of the Implantable Cardioverter Defibrillator Versus Amiodarone: Eleven-Year Follow-Up of a Subset of Patients in the Canadian Implantable Defibrillator Study (CIDS)”
Authors: Giuseppe Boriani, Mauro Biffi, Cristian Martignani
Journal: Circulation (2005)
Development of anti-atherosclerotic tissue-engineered blood vessel by A20-regulated endothelial progenitor cells seeding decellularized vascular matrix
Authors: Chuhong Zhu, Dajun Ying, Jianhong Mi, Li Li, Wen Zeng, Chunli Hou, Jiansen Sun, Wei Yuan, Can Wen, Wei Zhang
Journal: Biomaterials (2008)
MECHANICS OF BACK STRAINS
Authors: Z. B. ADAMS
Journal: JAMA (1925)

It is not possible to say anything new about back strairs, but it will perhaps be of interest to go over the mechanics of the joints in the different regions of the spine, in order to show the effect of the shift of their relative positions to one another, on the stress brought on the ligaments, and thus to show where strains usually occur. In regard to ligamentous strains, I believe that we have in the back a condition exactly similar to that which takes place in the feet with improper shoeing, and use. The ligaments of the foot, being repeatedly and continually stretched (when held in improper position), become painful. This does not mean that some persons with partly or very flat feet cannot walk about without pain; for, in that case, the ligaments have been stretched for a long time, have adjusted themselves to their new length, and
Muscle and splanchnic glutamine and glutamate metabolism in postabsorptive and starved man
Authors: E. B. Marliss, T. T. Aoki, T. Pozefsky, A. S. Most, G. F. Cahill
Journal: Journal of Clinical Investigation (1971)

Arterio-venous differences across forearm muscle in man in both prolonged starvation and in the postabsorptive state, show an uptake of glutamate and a relatively greater production of glutamine. Splanchnic arteriovenous differences in the postabsorptive state show a net uptake of glutamine and lesser rate of glutamate production. These data suggest that muscle is a major site of glutamine synthesis in man, and that the splanchnic bed is a site of its removal. The relative roles of liver and other tissues in the splanchnic circuit were not directly assessed, only the net balance. These data in man are in conflict with most previous studies in other species attributing the major proportion of glutamine production to the liver and, pari passu, to the splanchnic bed.