Granulomatous Hepatitis
Authors: JAMES C. GUCKIAN
Journal: Annals of Internal Medicine (1966)

Review1 November 1966Granulomatous HepatitisAn Analysis of 63 Cases and Review of the LiteratureJAMES C. GUCKIAN, M.D., JOHN E. PERRY, M.D.JAMES C. GUCKIAN, M.D., JOHN E. PERRY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1081 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGranulomas in the liver may result from many diseases of man. One of the most perplexing problems in medicine is to arrive at a diagnosis in a patient whose liver biopsy shows noncaseating granulomas in the absence of identifiable organisms. This is not an uncommon problem as reflected by a 3 to 10% prevalence of granulomas in liver biopsies performed at general hospitals (1-4). There are several reviews of hepatic granulomas (4-7), and Table 1 lists the various diseases with which they have been associated.Although there are many causes for granulomatous hepatitis, it is probable that the pathogenesis is...References1. SCHIFF L: The clinical value of needle biopsy of the liver. Ann. Intern. Med. 34: 948, 1951. LinkGoogle Scholar2. EDMONDSON HA: Needle biopsy in differential diagnosis of acute liver disease. JAMA 191: 480, 1965. CrossrefMedlineGoogle Scholar3. RUBIN E: Interpretation of the liver biopsy. Diagnostic criteria. Gastroenterology 45: 400, 1963. CrossrefMedlineGoogle Scholar4. WAGONERANTONGALLSHIFF GPATEAL: Needle biopsy of the liver. VII. Experiences with hepatic granulomas. Gastroenterology 25: 487, 1953. CrossrefMedlineGoogle Scholar5. KLATSKINYESNER GR: Hepatic manifestations of sarcoidosis and other granulomatous diseases. Yale J. Biol. Med. 23: 207, 1950. MedlineGoogle Scholar6. FRANKRAFFENSPERGER BBEC: Hepatic granulomata. Report of a case with jaundice improving on antituberculous therapy and review of the literature. Arch. Intern. Med. (Chicago) 115: 223, 1965. CrossrefMedlineGoogle Scholar7. BUNIMKIMBERGTHOMASVAN SCOTTKLATSKIN JJDVLBEJG: The syndrome of sarcoidosis, psoriasis and gout: combined clinical staff conference at the National Institutes of Health. Ann. Intern. Med. 57: 1018, 1962. LinkGoogle Scholar8. JAHIELKOFFLER RID: Hepatic granulomas induced in guinea-pigs by Freund's adjuvant with and without homologous liver. Brit. J. Exp. Path. 42: 338, 1961. MedlineGoogle Scholar9. CAMERON R: Inflammation and repair, in Textbook of Pathology with Clinical Application, 2nd ed., edited by ROBBINS, S. L. W. B. Saunders Co., Philadelphia and London, 1962, p. 75. Google Scholar10. PETERSDORFBEESON RGPB: Fever of unexplained origin: report on 100 cases. Medicine (Balt.) 40: 1, 1961. CrossrefMedlineGoogle Scholar11. KOENIGCOLLINSHEYSSEL MGRDRM: Disseminated mycobacteriosis caused by Battey type mycobacteria. Ann. Intern. Med. 64: 145, 1966. LinkGoogle Scholar12. WOODBUHLERPOLLAK LEVDH: Human infection with the "yellow" acid bacillus—a report of fifteen additional cases. Amer. Rev. Tuberc. 73: 917, 1956. Google Scholar13. MCCUSKERGREEN JJRA: Generalized non-tuberculous mycobacteriosis. Report of two cases. Amer. Rev. Resp. Dis. 86: 405, 1962. Google Scholar14. KLATSKIN G: Hepatitis associated with systemic infection in Diseases of the Liver, 2nd ed., edited by SCHIFF, L. J. B. Lippincott Co., Philadelphia and Montreal, 1963, p. 545. Google Scholar15. KORNKELLOWHELLERCHOMETZIMMERMAN RJWFPBHJ: Hepatic involvement in extrapulmonary tuberculosis—histologic and functional characteristics. Amer. J. Med. 27: 60, 1959. CrossrefMedlineGoogle Scholar16. GOLDWIGDERSONLEHMANSCHWARTZ JAEIR: Tuberculous hepatitis—report of a case with review of the literature. Gastroenterology 33: 113, 1957. CrossrefMedlineGoogle Scholar17. YAMAGUCHIBRAUNSTEIN BTH: Fluorescent stain for tubercle bacilli in histologic sections. II. Diagnostic efficiency in granulomatous lesions of the liver. Amer. J. Clin. Path. 43: 184, 1965. CrossrefGoogle Scholar18. ROSSIBERHARVEY RSFLAM: The serum alkaline phosphatase in chronic infiltrative disease of the liver. Amer. J. Med. 21: 850, 1956. CrossrefMedlineGoogle Scholar19. PARDO-CASTELLOTIANT VFR: Leprosy—the correlation of its chemical, pathologic, immunologic, and bacteriologic aspects. JAMA 121: 1264, 1943. CrossrefGoogle Scholar20. BROWNE SG: The liver in leprosy: a review. W. Afr. Med. J. 13: 35, 1964. MedlineGoogle Scholar21. BERNSTEIN A: Tularemia—report of three fatal cases with autopsies. Arch. Intern. Med. (Chicago) 56: 1117, 1935. CrossrefGoogle Scholar22. PULLENSTUART RLBM: Tularemia—analysis of 225 cases. JAMA 129: 495, 1945. CrossrefGoogle Scholar23. SPINKHOFFBAUERWALKERGREEN WWFWWWRA: Histopathology of the liver in human brucellosis. J. Lab. Clin. Med. 34: 40, 1949. MedlineGoogle Scholar24. SPINK WW: Brucellosis, in Immunological Diseases, edited by SAMTER, M., ALEXANDER, H. L., TALMAGE, D. W., ROSE, B., SHERMAN, W. B., VAUGHN, J. H. Little, Brown and Co., Boston, 1965, p. 455. Google Scholar25. MCCULLOUGHEISELE NBCW: Brucella hepatitis leading to cirrhosis of the liver. Arch. Intern. Med. (Chicago) 88: 793, 1951. CrossrefGoogle Scholar26. JOSKEFINCKH RAES: Hepatic changes in human brucellosis. Med. J. Aust. 2: 266, 1955. CrossrefGoogle Scholar27. SHAPIROWEINER EH: The diagnosis of tertiary syphilis of the liver: 25 years after McCrae. Amer. J. Med. Sci. 222: 494, 1951. CrossrefMedlineGoogle Scholar28. BERNSTEINEDMONDSONBARBOUR MHABH: The liver lesion in Q-fever. Arch. Intern. Med. (Chicago) 116: 491, 1965. CrossrefMedlineGoogle Scholar29. PICCHINELSONWALLERRAZAVICLIZER JAREEMEE: Q fever associated with granulomatous hepatitis. Ann. Intern. Med. 53: 1065, 1960. LinkGoogle Scholar30. POWELL OW: Liver involvement in "Q" fever. Aust. Ann. Med. 10: 52, 1961. CrossrefMedlineGoogle Scholar31. ALKANEVENCHIKESHCHAR WJZJ: Q fever and infectious hepatitis. Amer. J. Med. 38: 54, 1965. CrossrefMedlineGoogle Scholar32. MARCIAL ROJAS RA: Helminthic diseases, in Diseases of the Liver, 2nd ed., edited by SCHIFF, L. J. B. Lippincott Co., Philadelphia and Montreal, 1963, p. 800. Google Scholar33. KHALEQUEALAM KAKS: Hepatic granuloma caused by Ascaris ova. J. Trop. Med. Hyg. 66: 249, 1963. MedlineGoogle Scholar34. HAMILTONHUTCHINSONJAMISONJONES PKHSPWHL: The pathology and pathogenesis of the hepatosplenic disease associated with schistosomiasis. Amer. J. Clin. Path. 32: 18, 1959. CrossrefMedlineGoogle Scholar35. MENDELOFF J: Healed granulomas of the liver due to tongue worm infection. Amer. J. Clin. Path. 43: 433, 1965. CrossrefMedlineGoogle Scholar36. DRURY RA: Larval granulomata in the liver. Gut 3: 289, 1962. CrossrefMedlineGoogle Scholar37. DOXIADESCANDREVIOTISYIOTSASSMYRNIOTIS TNZDFE: Chronic amebic hepatitis. Clinical and experimental observations. Arch. Intern. Med. (Chicago) 111: 219, 1963. CrossrefGoogle Scholar38. KEAN BH: Amebic hepatitis—absence of diffuse lesions at autopsy and in biopsies. Arch. Intern. Med. (Chicago) 96: 667, 1955. CrossrefGoogle Scholar39. HARVEYCANTRELLFISHER JCJRAM: Actinomycosis: its recognition and treatment. Ann. Intern. Med. 46: 868, 1957. LinkGoogle Scholar40. CAWLEY EP: Aspergillosis and the aspergilli—report of a unique case of the disease. Arch. Intern. Med. (Chicago) 80: 423, 1947. CrossrefGoogle Scholar41. MURRAYFINEGOLDFROMANWILL JFSMSDW: The changing spectrum of nocardiosis. A review and presentation of nine cases. Amer. Rev. Resp. Dis. 83: 315, 1961. MedlineGoogle Scholar42. HATHAWAYMASON BMKN: Nocardiosis. Study of fourteen cases. Amer. J. Med. 32: 903, 1962. CrossrefMedlineGoogle Scholar43. SCHWARTZMUTH JJ: Coccidioidomycosis: a review. Amer. J. Med. Sci. 221: 89, 1951. CrossrefMedlineGoogle Scholar44. MARTINSMITH DSDT: Blastomycosis. II. A report of thirteen new cases. Amer. Rev. Tuberc. 39: 488, 1939. Google Scholar45. BÜNGELER W: Üper die brasilianische Blastomykose und den histologischen Nachweis der Paracoccidioides brasiliensis. Virchow Arch. Path. Anat. 309: 76, 1942. CrossrefGoogle Scholar46. ISRAELDELAMATERSONESWILLISMIRMELSTEIN HLEMWDA: Chronic disseminated histoplasmosis—an investigation of its relationship to sarcoidosis. Amer. J. Med. 12: 252, 1952. CrossrefMedlineGoogle Scholar47. PINKERTONIVERSON HL: Histoplasmosis—three fatal cases with disseminated sarcoid-like lesions. Arch. Intern. Med. (Chicago) 90: 456, 1952. CrossrefGoogle Scholar48. WINNERHURLEY HIR: Candida Albicans. Little, Brown and Co., Boston, 1964, p. 48. Google Scholar49. FRENCHSHENOI GV: Disseminated moniliasis with demonstration of the organism in the blood. Canad. Med. Ass. J. 71: 238, 1954. MedlineGoogle Scholar50. LITTMANZIMMERMAN MLLE: Cryptococcosis-Torulosis. Grune & Stratton, New York and London, 1956, p. 83. Google Scholar51. GENDELENDENORMAN BRMSL: Cryptococcosis—a review with specific reference to apparent association with Hodgkin's disease. Amer. J. Med. 9: 243, 1950. Google Scholar52. SHIELDS LH: Disseminated cryptococcosis producing a sarcoid type reaction: the report of a case treated with amphotericin B. Arch. Intern. Med. (Chicago) 104: 763, 1959. CrossrefMedlineGoogle Scholar53. STINEMANKORNZIMMERMAN RSRJHJ: Hepatic function studies in lymphogranuloma venereum. Arch. Intern. Med. (Chicago) 96: 799, 1955. CrossrefGoogle Scholar54. JORGENSEN L: Lymphogranuloma venereum. A study of the pathology and the pathogenetic problems based on observation of eight cases examined post mortem. Acta Path. Microbiol. Scand. 47: 113, 1959. CrossrefMedlineGoogle Scholar55. LYFORDJOHNSONBLACKMANSCOTT JRWSRB: Pathologic findings in a fatal case of disseminated granuloma inguinale with miliary bone and joint involvement. Bull. Hopkins Hosp. 79: 349, 1946. MedlineGoogle Scholar56. KLATSKIN G: Toxic and drug-induced hepatitis, in Diseases of the Liver, 2nd ed., edited by SCHIFF, L. J. B. Lippincott Co., Philadelphia and Montreal, 1963, p. 470. Google Scholar57. VAN ORDSTRAND HS: Current concepts of beryllium poisoning. Ann. Intern. Med. 35: 1203, 1951. LinkGoogle Scholar58. MOREMCMILLANDUFF RHGCGL: The pathology of sulfonamide allergy in man. Amer. J. Path. 22: 703, 1946. Google Scholar59. O'BRIEN DJ: Death from hypersensitivity due to phenylbutazone. Brit. Med. J. 1: 792, 1954. CrossrefMedlineGoogle Scholar60. BRANSONPARK JHJH: Sarcoidosis—hepatic involvement: presentation of a case with fatal liver involvement, including autopsy findings and review of the evidence for sarcoid involvement of the liver as found in the literature. Ann. Intern. Med. 40: 111, 1954. LinkGoogle Scholar61. LONGCOPEFREIMAN WTDG: A study of sarcoidosis. Medicine (Balt.) 31: 1, 1952. CrossrefMedlineGoogle Scholar62. NOLANKLATSKIN JPG: The fever of sarcoidosis. Ann. Intern. Med. 61: 455, 1964. LinkGoogle Scholar63. PORTER GH: Hepatic sarcoidosis. A cause of portal hypertension and liver failure; review. Arch. Intern. Med. (Chicago) 108: 483, 1961. CrossrefMedlineGoogle Scholar64. CHURGSTRAUSS JL: Allergic granulomatosis, allergic angiitis and periarteritis nodosa. Amer. J. Path. 27: 277, 1951. MedlineGoogle Scholar65. SOKOLOVRACHMANINOFFKAINE RANHD: Allergic granulomatosis. Amer. J. Med. 32: 131, 1962. CrossrefMedlineGoogle Scholar66. CHURG J: Allergic granulomatosis and granulomatous-vascular syndromes. Ann. Allerg. 21: 619, 1963. MedlineGoogle Scholar67. BRIDGESBERENDESGOOD RAHRA: Fatal granulomatous disease of childhood. J. Dis. Child. 97: 387, 1959. CrossrefMedlineGoogle Scholar68. EVANSEDGCOMB HEJH: Unexplained granulomatosis in childhood. A clinicopathological dilemma. Arch. Path. 74: 360, 1962. Google Scholar69. CARSONCHADWICKBRUBAKERCHELANDLANDING MJDLCARSBH: Thirteen boys with progressive septic granulomatosis. Pediatrics 35: 405, 1965. CrossrefMedlineGoogle Scholar70. KAPPASSOYBELFUKUSHIMAGALLAGHER AWDKTF: Studies on pyrogenic steroids in man. Trans. Ass. Amer. Physicians 72: 54, 1959. Google Scholar71. BONDYCOHNGREGORY PKGLPB: Etiocholanolone fever. Medicine (Balt.) 44: 249, 1965. CrossrefMedlineGoogle Scholar72. SHENKERWILSONSPICKARD SHA: Periodic fever associated with increased plasma unconjugated etiocholanolone and granulomatous liver disease: case report and studies in etiocholanolone and cortisol conjugation. J. Clin. Endocr. 23: 95, 1963. CrossrefGoogle Scholar73. LEVITANDIAMONDCRAVER RHDLF: Jaundice in Hodgkin's disease. Amer. J. Med. 30: 99, 1961. CrossrefMedlineGoogle Scholar74. KLATSKIN G: Infectious mononucleosis, in Diseases of the Liver, 2nd ed., edited by SCHIFF, L. J. B. Lippincott Co., Philadelphia and Montreal, 1963, p. 562. Google Scholar75. KILPATRICK Z: Structural and functional abnormalities of liver in infectious mononucleosis. Arch. Intern. Med. (Chicago) 117: 47, 1966. CrossrefMedlineGoogle Scholar76. NELSONDARRAGH RSJH: Infectious mononucleosis hepatitis. Amer. J. Med. 21: 26, 1956. CrossrefMedlineGoogle Scholar77. KAUFMAN L: Serology of systemic fungus disease. Public Health Rep. 81: 177, 1966. CrossrefMedlineGoogle Scholar78. NICHOLASWIERKUHNCAMPBELLNOLTEHILL WMJALRCCLBGB: Serologic effects of histoplasmin skin testing. Amer. Rev. Resp. Dis. 83: 276, 1961. MedlineGoogle Scholar79. CAMPBELLHILL CCGB: Further studies on the development of complement-fixing antibodies and precipitins in healthy histoplasmin-sensitive persons following a single histoplasmin skin test. Amer. Rev. Resp. Dis. 90: 927, 1964. MedlineGoogle Scholar80. MAYSHAWKINSKUHN EEJALR: The clinical usefulness of fungal serologic testing. Dis. Chest 46: 205, 1964. CrossrefMedlineGoogle Scholar81. BORCHADTSTANSIFERALBANO KAPPM: Osteomyelitis due to Pseudomonas pseudomallei. JAMA 196: 660, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES C. GUCKIAN, M.D.; JOHN E. PERRY, M.D.Affiliations: Galveston, TexasFrom the Division of Infectious Diseases, Department of Internal Medicine, the University of Texas Medical Branch, Galveston, Tex.This study was supported by the Jeane B. Kempner Scholarship Fund, Galveston, Tex.Requests for reprints should be addressed to James C. Guckian, M.D., University of Texas Medical Branch, Galveston, Tex. 77550. 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