tbuckley/cabot-search huggingface dataset:
Role of calcium and the calcium channel in the initiation and maintenance of ventricular fibrillation.
Authors: J C Merillat, E G Lakatta, O Hano, T Guarnieri
Journal: Circulation Research (1990)

The cellular events during the initiation and maintenance of ventricular fibrillation (VF) are poorly understood. We developed a nonischemic, isolated, perfused rabbit Langendorff preparation in which sustained VF could be induced by alternating current (AC) and which allowed changes in perfusate composition. We also used Na(+)-K+ pump inhibition (10 microM ouabain or K(+)-free perfusate) to induce VF. AC stimulation or Na(+)-K+ pump inhibition always initiated VF. Calcium channel blockade by verapamil or nitrendipine uniformly inhibited the initiation of VF in both models. During Na(+)-K+ pump inhibition, 1) VF was prevented by calcium channel blockade, despite evidence of Ca2+ overload, and 2) abolition of spontaneous sarcoplasmic reticulum-generated cytosolic Ca2+ oscillations by ryanodine or Na+ channel blockade with tetrodotoxin did not prevent VF initiation. Lowering extracellular [Ca2+] to 80 microM uniformly prevented the initiation of VF due to Na(+)-K+ pump inhibition but not that due to AC stimulation. VF maintenance also was studied using 1) reduction in perfusate [Ca2+], 2) blockade of Ca2+ channels, or 3) electrical defibrillation. Decreasing the perfusate [Ca2+] to 80 microM resulted in defibrillation during VF whether induced by AC or Na(+)-K+ pump inhibition. Verapamil or nitrendipine also resulted in defibrillation regardless of the initiation method. Electrical defibrillation was successful only in AC-induced VF. The results demonstrate that VF can be initiated and maintained in a nonischemic rabbit Langendorff preparation. The data suggest that increases in slow channel Ca2+ flux, as opposed to increases in cytosolic Ca2+ per se, were necessary for the initiation and maintenance of VF. The data, however, do not exclude an important role for cytosolic Ca2+ in the modulation of VF.
Ophthalmic Manifestations of the Battered-baby Syndrome
Authors: B. Harcourt, D. Hopkins
Journal: BMJ (1971)

Eleven battered babies who had ocular manifestations of their abuse are presented. Eight of these suffered a permanent impairment of visual function. Ten had extensive intraocular haemorrhage, and the importance of this physical sign in the diagnosis of the syndrome and in the development of a consequent visual handicap is emphasized.
Pulmonary Dysfunction Following Traumatic Quadriplegia
Authors: John C. McMichan
Journal: JAMA (1980)

A prospective study of the pulmonary complications occurring in 22 consecutive patients admitted to hospital within 24 hours after acute traumatic quadriplegia was compared with the findings of a retrospective survey of 22 comparable patients. Patients in the prospective group received therapy designed to prevent or reverse secretion retention. All patients in this group survived. In the retrospective group there were nine deaths; pulmonary complications and the need for tracheal intubation and mechanical ventilation were three times more frequent. Serial pulmonary function testing in the prospective group demonstrated a greater compromise of expiration than inspiration and progressive improvement in diaphragm function with time. It is concluded that vigorous pulmonary therapy in the prospective group was associated with increased survival, a decreased incidence of pulmonary complications, and a decreased need for ventilatory support.
Serum testosterone level is the major determinant of the male-female differences in serum levels of high-density lipoprotein (HDL) cholesterol and HDL2 cholesterol
Authors: H. Asscheman, L.J.G. Gooren, J.A.J. Megens, J. Nauta, H.J. Kloosterboer, F. Eikelboom
Journal: Metabolism (1994)
Swedish Studies Link Hormone Use to Higher Breast Cancer Risk
Authors: K. Smigel
Journal: JNCI Journal of the National Cancer Institute (1989)

2 more reports on heightened risk of breast cancer in certain subsets of oral contraceptive and menopausal estrogen-progestin users have appeared from Sweden, in addition to 3 studies published in early 1989 that prompted the U.S. F.D.A. to re-evaluate its warning labels on pill packages inserts. The 1st study on 10 cases among 23,244 women from Uppsala found that women who took hormone replacement therapy briefly for menopausal symptoms had a 10% increased risk of breast cancer, while those taking hormones for 9 years or more had a 70% higher risk. The report estimated that women using combined estrogen-progestins for 6 years or more had a 4.4-fold risk of breast cancer appearing in the pre- menopausal age group. Women who used pills 5 or more years before the age of 25 had a 5.3-fold risk of breast cancer. Those using for 8 or more years before the 1st pregnancy had a 2.0-fold risk. These data analyzed 174 pre-menopausal women diagnosed with breast cancer in the early 1980s, and included many women who began pills in the 1960s. The author noted that we have no studies yet on the modern, lower-dose oral contraceptive pills.
217 Hepatocyte-specific disruption of BCL-X leads to spontaneous and persistent hepatocyte apoptosis and liver fibrogenic response: in vivo evidence for the link between apoptosis and fibrosis
Authors: T TAKEHARA, T SUZUKI, C OHNISHI, E RUCKERIII, M JINUSHI, T MIYAGI, N HIRAMATSU, N HAYASHI
Journal: Hepatology (2003)
Computerized Blood-flow Analysis in Osteochondritis Dissecans
Authors: R W McCULLOUGH, E J GANDSMAN, H LITCHMAN, S L SCHATZ, S D DEUTSCH
Journal: Clinical Nuclear Medicine (1986)

A retrospective review of static images and computerized blood flow studies (CBFS) in patients with osteochondritis dissecans (OCD) suggests that CBFS maybe useful in following the clinical course of this disease.
Recruitment mechanisms of primary and malignant B cells to the human liver
Authors: Shishir Shetty, Tony Bruns, Christopher J. Weston, Zania Stamataki, Ye H. Oo, Heather M. Long, Gary M. Reynolds, Guy Pratt, Paul Moss, Sirpa Jalkanen, Stefan G. Hubscher, Patricia F. Lalor, David H. Adams
Journal: Hepatology (2012)

B cells are present within chronically inflamed liver tissue and recent evidence implicates them in the progression of liver disease. In addition, a large proportion of hepatic lymphomas are of B-cell origin. The molecular signals that regulate normal and malignant B-cell recruitment into peripheral tissue from blood are poorly understood, leading us to study human B-cell migration through hepatic sinusoidal endothelial cells in flow-based adhesion assays. In such assays, human blood-derived B cells were captured from shear flow without a previous rolling phase and underwent firm adhesion mediated by vascular cell adhesion molecule-1 (VCAM-1). Unlike T cells, which displayed vigorous crawling behavior on the endothelium, B cells remained static before a proportion underwent transendothelial migration mediated by a combination of intercellular adhesion molecule-1 (ICAM-1), vascular adhesion protein-1, common lymphatic endothelial and vascular endothelial receptor-1/stabilin-1, and the chemokine receptors, CXCR3 and CXCR4. B-cell lymphoma cell lines and primary malignant B cells from patients with chronic lymphocytic leukemia and marginal zone B cell lymphoma also underwent integrin-mediated firm adhesion involving ICAM-1 and/or VCAM-1 and demonstrated ICAM-1-dependent shape-change and crawling behavior. Unlike primary lymphocytes, the malignant cells did not undergo transendothelial migration, which could explain why lymphomas are frequently characterized by the intravascular accumulation of malignant cells in the hepatic sinusoids. Conclusion: Our findings demonstrate that distinct combinations of signals promote B-cell recruitment to the liver, suggesting the possibility of novel targets to modulate liver inflammation in disease. Certain features of lymphocyte homing are maintained in lymphoma recruitment to the liver, suggesting that therapeutic targets for lymphocyte recruitment may also prevent hepatic lymphoma dissemination. (HEPATOLOGY 2012)
Episodic Stupor Associated with an Eck Fistula in the Human with Particular Reference to the Metabolism of Ammoniaxs12
Authors: William V. McDermott, Raymond D. Adams
Journal: Journal of Clinical Investigation (1954)

The effect on animals of ligating the portal vein and diverting the blood from the portal system directly into the inferior vena cava through a surgically constructed fistula was first studied by Eck in 1877 (1).As a mark of respect for the ingenuity of these experiments, the eponym, "Eck fistula," has been perpetuated in medical writings.Animals so treated can be made to survive for long pe- riods of time in apparently good health and therefore the Eck fistula has been used extensively as a means of investigating the metabolic activities of the liver.Although dogs with an Eck fistula may remain in good clinical condition, it has been demonstrated that the liver undergoes a certain amount of atrophy; the production of plasma pro- teins, hemoglobin, and bile pigments is diminished; serum lipid levels are low despite adequate fat absorption; and the consumption and urinary output of water are increased (2-5).Perhaps the most interesting and controversial observation derived from these experiments has been the phenomenon of "meat intoxication," a neurological disorder consisting of stupor, ataxia, convulsions, and finally coma, which occurs in Eck fistula dogs either after the ingestion of meat, or spontaneously.This phenomenon has been studied extensively (6-10) and, while it has been suggested that vari- ous degradation products of protein metabolism are responsible, the pathogenesis actually remains obscure.Construction of an anastomosis between the portal vein and the inferior vena cava with or with- out interruption of the portal vein is frequently carried out in patients with portal hypertension for the treatment of esophageal varices.This anasto-
Long‐term association between self‐reported signs and symptoms and heart failure hospitalizations: the Atherosclerosis Risk In Communities (ARIC) Study
Authors: Christy L. Avery, Katherine T. Mills, Lloyd E. Chambless, Patricia P. Chang, Aaron R. Folsom, Thomas H. Mosley, Hanyu Ni, Wayne D. Rosamond, Lynne Wagenknecht, Joy Wood, Gerardo Heiss
Journal: European Journal of Heart Failure (2010)
Paralysis Following Removal of Gasserian Ganglion.
Authors: Harry M. Sherman
Journal: JAMA (1907)

Percussion of the chest by ordinary methods is at best un- satisfactory; and, as practiced by many physicians, is unreli- able and worthless.During recent years I have acquainted myself with most of the different varieties of percussion and have compared my findings by one with that of the others.I find that the various methods have different value under differ¬ ent circumstances.By being conversant with more than one method one is able to do more accurate work.
Christian Views of Current Issues
Authors: CLAUDE A. FRAZIER
Journal: Annals of Internal Medicine (1974)

Comments1 June 1974Christian Views of Current IssuesCLAUDE A. FRAZIER, M.D.CLAUDE A. FRAZIER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-6-782_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am currently editing a book on the personal testimonies of Christian physicians and what they think about the medical-ethical issues of today, that is, abortion, euthanasia, organ transplants, when is a person officially dead, sterilization, psychosurgery, semen donors, ovum donors, host mothers, reversed aging, artificial organs, genetic counseling, and so on. I would be interested in hearing from any Christian physician who could contribute to such a book or who would be able to suggest a Christian physician to write for this book. Please contact me at the following address.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CLAUDE A. FRAZIER, M.D.Affiliations: 4-C Doctor's Park Asheville, North Carolina 28801 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1974Volume 80, Issue 6 Page: 782-782 Keywords Aging Euthanasia Genetic counseling Hearing Semen ePublished: 1 December 2008 Issue Published: 1 June 1974 PDF downloadLoading ...
ULCERATIVE COLITIS COMPLICATING TUBERCULOUS MENINGITIS
Authors: C.S. James, J.W. Shuman
Journal: JAMA (1921)

<h3>History.</h3> —I. J., a man, aged 19, American, miner, whose father and mother were living and well, who had one sister living, and whose family history was negative as to tuberculosis, cancer and syphilis, was said by the parents never to have been quite right, always being dull and stupid, and to have had asthma for the last three years. The patient became ill, Sept. 8, 1911, with an "asthma-like attack" and pain in the left ear; but no pathologic lesions were found. Five days later his physician found him restless and complaining of pain in the left ear. The temperature was 101 F. He was mentally dull. On consultation, September 16, a diagnosis of mastoiditis was made, and the patient was removed to St. Joseph Mercy Hospital, Centerville, Iowa. <h3>Examination.</h3> —On admission the patient's temperature was 101.5; pulse, 120; respiration, 18. He was aroused with difficulty. A polyp filled
Chemical burns beneath tourniquets
Authors: R. Madhok
Journal: BMJ (1989)

significance.In a recent study urinary tract abnormalities were found in 47% of children investigated as a result of this finding.'Dr Smyth and her colleagues ask for an agreed common approach to the investigation and management of urinary tract infection in children.Until studies of the different investigation protocols are completed, and in view of the variable facilities available, an approach is unlikely to be agreed.It is paramount, however, that recurrent or persistent infection should be promptly detected and appropriately acted upon.I have recently attempted to set out protocols, both for general practitioners and for paediatricians, which, provided that good microbiological facilities are available, may be used to determine pathways of investigation and management appropriate to the individual child.4
Comparison of hepatic properties and transplantation of Thy-1<sup>+</sup>and Thy-1<sup>−</sup>cells isolated from embryonic day 14 rat fetal liver
Authors: Michael Oertel, Anuradha Menthena, Yuan-Qing Chen, David A. Shafritz
Journal: Hepatology (2007)

Abstract Thy-1, a marker of hematopoietic progenitor cells, is also expressed in activated oval cells of rat liver. Thy-1+ cells are also in rat fetal liver and exhibit properties of bipotent hepatic epithelial progenitor cells in culture. However, no information is available concerning liver repopulation by Thy-1+ fetal liver cells. Therefore, we isolated Thy-1+ and Thy-1− cells from embryonic day (ED) 14 fetal liver and compared their gene expression characteristics in vitro and proliferative and differentiation potential after transplantation into adult rat liver. Fetal liver cells selected for Thy-1 expression using immunomagnetic microbeads were enriched from 5.2%-87.2% Thy-1+. The vast majority of alpha fetoprotein+, albumin+, cytokine-19+, and E-cadherin+ cells were found in cultured Thy-1− cells, whereas nearly all CD45+ cells were in the Thy-1+ fraction. In normal rat liver, transplanted Thy-1+ cells produced only rare, small DPPIV+ cell clusters, very few of which exhibited a hepatocytic phenotype. In retrorsine-treated liver, transplanted Thy-1+ fetal liver cells achieved a 4.6%-23.5% repopulation. In contrast, Thy-1− fetal liver cells substantially repopulated normal adult liver and totally repopulated retrorsine-treated liver. Regarding the stromal cell–derived factor (SDF)–1/chemokine (C-X-C motif) receptor 4 (CXCR4) axis for stem cell homing, Thy-1+ and Thy-1− fetal hepatic epithelial cells equally expressed CXCR4. However, SDF-1α expression was augmented in bile ducts and oval cells in retrorsine/partial hepatectomy–treated liver, and this correlated with liver repopulation by Thy-1+ cells. Conclusion: Highly enriched Thy-1+ ED14 fetal liver cells proliferate and repopulate the liver only after extensive liver injury and represent a fetal hepatic progenitor cell population distinct from Thy-1− stem/progenitor cells, which repopulate the normal adult liver. (HEPATOLOGY 2007.)
Endoscopic Dilation for Treatment of Anastomotic Leaks Following Transhiatal Esophagectomy
Authors: D. K. Bhasin, B. C. Sharma, N. M. Gupta, S. K. Sinha, K. Singh
Journal: Endoscopy (2000)

Background and Study Aims: Anastomotic leak is a known complication after transhiatal esophagectomy (THE) and cervical esophagogastric anastomosis. Conservative management takes a long time to heal such leaks. We assessed the role of endoscopic dilation in patients with anastomotic leak following THE.
A Social-Psychological Approach to the Specificity of Psychosomatic Diseases
Authors: Karola Brede
Journal: Psychotherapy and Psychosomatics (1977)

Research Articles| February 16 2010 A Social-Psychological Approach to the Specificity of Psychosomatic Diseases Subject Area: Psychiatry and Psychology Karola Brede Karola Brede Frankfurt/Main Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1977) 28 (1-4): 230–235. https://doi.org/10.1159/000287067 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Karola Brede; A Social-Psychological Approach to the Specificity of Psychosomatic Diseases. Psychother Psychosom 31 December 1977; 28 (1-4): 230–235. https://doi.org/10.1159/000287067 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1977Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions
Authors: Carlotta Costa, Giulia Germena, Erica L. Martin-Conte, Ivan Molineris, Eleonora Bosco, Stefano Marengo, Ornella Azzolino, Fiorella Altruda, V. Marco Ranieri, Emilio Hirsch
Journal: Blood (2011)
TCT-481 Treatment of "resistant" in-stent restenosis in the drug-eluting era: comparison of repeat stent versus balloon only strategy
Authors: Marco G. Mennuni, Kleanthis Theodoropoulos, Omar A. Meelu, Pedro R. Moreno, Prakash Krishnan, Jason Kovacic, Usman Baber, Melissa Aquino, Samantha Sartori, Robert T. Pyo, Joe Sweeny, George Dangas, Roxana Mehran, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2013)
Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life
Authors: Tadashi Ikeda, Andrew M. L. Lever, Howard C. Thomas
Journal: Hepatology (1986)

Ninety per cent of patients infected in adult life with the hepatitis B virus clear the virus completely and 10% develop chronic infection. There is evidence for the involvement of interferon in the clearance of acute hepatitis B virus infection. We report that, in in vitro tests, some hepatitis B virus carriers have a reduced capacity to produce α- and γ-interferon which is unrelated to the level of viral replication and to the severity of the liver disease and that the level of 2-5 oligoadenylate synthetase in their livers is only minimally elevated compared to controls. Treatment with lymphoblastoid (α−) interferon leads to a marked rise in 2-5 oligoadenylate synthetase activity. These data indicate that some patients with chronic hepatitis B virus infection acquired in adult life have a partial deficiency of production of α-interferon but can respond to exogenous α-interferon. These observations provide a logical basis for attempts to treat this condition with interferons.
Sources of Lead Poisoning
Authors: Carolyn Levitt, Jan Godes, Mark Eberhardt, Roy Ing, James M. Simpson
Journal: JAMA (1984)

<h3>To the Editor.—</h3> A primary aim of childhood lead poisoning prevention programs in the United States is to identify sources of lead exposure and to prevent future exposure. House paints that contain lead often are identified as the most likely source of environmental lead to which children are exposed, especially children living in old homes in urban settings. The search for sources of lead, however, should include life-style factors in addition to the presence of lead in the physical environment. Recent reports of lead in ethnic folk remedies emphasize this point. Through lead screening programs and case reports of lead toxicity,<sup>1,2</sup>several folk remedies have been documented as sources of lead poisoning in children. One such remedy is<i>Azarcon</i>, a bright orange powder used by Mexican-Hispanic parents to treat chronic indigestion or "empacho" in their children. Several samples tested were found to contain 86% to 93.5% lead tetroxide.<sup>2</sup>
The ENHANCE Study and Marketing Ezetimibe
Authors: Fatima Akdim, John J. P. Kastelein, Daniel Gaudet
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal