tbuckley/cabot-search huggingface dataset:
Variant Angina Pectoris
Authors: MICHAEL M. LAKS
Journal: Annals of Internal Medicine (1973)

Letters, Comments, and Corrections1 February 1973Variant Angina PectorisMICHAEL M. LAKS, M.D., F.A.C.P., JAMES DAHLGREN, M.D., WILLIAM J. MANDEL, M.D., F.A.C.P.MICHAEL M. LAKS, M.D., F.A.C.P., JAMES DAHLGREN, M.D., WILLIAM J. MANDEL, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-2-309_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The availability of a device for the continuous monitoring of electrograms has made possible the detection of occult arrhythmias (1-3). In a case of variant angina pectoris, transient ST-segment elevation was discovered initially by the dynamic electrogram (DECG) (Holter-Avionics system, Electrocardiocorder #350c, Electrocardioscanner #650).A 60-year-old male was admitted to the hospital for a diagnostic workup for microscopic hematuria. A routine electrocardiogram showed a complete right bundle-branch block, left anterior hemiblock, and premature ventricular and atrial contractions. A dynamic ECG was ordered to detect the possible presence of dysrhythmias that would require the insertion of an artificial...References1. HOLTER N: New method for heart studies. Science 139:1214-1220, 1961 CrossrefGoogle Scholar2. CORDAYBAZIKALANG EVT: Detection of phantom arrhythmias and advancement to its cardiographic abnormality. JAMA 193:417-421, 1965 CrossrefMedlineGoogle Scholar3. HINKELMEYERSTEVENS LJM: Tape recordings of the ECG of active men. Limitations and advantages of the Holter-Avionics instruments. Circulation 36:752-765, 1967 CrossrefMedlineGoogle Scholar4. PRINZMETALKENNAMERMERLIS MRR: Angina pectoris. I. A variant form of angina pectoris. Am J Med 27:375-388, 1959 CrossrefMedlineGoogle Scholar5. WHITINGKLEINVEER RMJ: Variant angina pectoris. N Engl J Med 282:709-712, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Cardiology Harbor General Hospital Torrance, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByReply—IIAcute myocardial infarction and angiographically normal coronary arteries. An unproven combination.Myocardial infarction after exercise-induced electrocardiographic changes in a patient with variant angina pectoris 1 February 1973Volume 78, Issue 2Page: 309-310KeywordsAnginaArrhythmiaElectrocardiographyElectrophysiological techniquesRight bundle branch block Issue Published: 1 February 1973 PDF DownloadLoading ...
KERATODERMIA BLENNORRHAGICA TREATED WITH CORTISONE.*
Authors: HERBERT SCHWARZ, HARRE KINGMA
Journal: British Journal of Dermatology (1952)

Journal Article KERATODERMIA BLENNORRHAGICA TREATED WITH CORTISONE. Get access HERBERT SCHWARZ, M. R. C. S.(Eng.), HERBERT SCHWARZ, M. R. C. S.(Eng.) Medical Research Fellow, Department of Medicine, Ottawa University Medical School; Physician, Ottawa General Hospital, and Search for other works by this author on: Oxford Academic Google Scholar HARRE KINGMA, M. D. HARRE KINGMA, M. D. Lecturer in Dermatology, Ottawa University Medical School; Dermatologist, Ottawa General Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 64, Issue 10, 1 October 1952, Page 388, https://doi.org/10.1111/j.1365-2133.1952.tb15803.x Published: 01 October 1952
Ronald Marsden Harvey
Authors: Donal Keegan
Journal: BMJ (2004)

Former consultant otorhinolaryngologist Londonderry (b London 1918; q King's College Hospital, London, 1943; FRCS, DLO, OBE), d 7 April 2004.

Ronald Harvey was appointed a consultant in ear, nose, and throat surgery in 1954, firstly at the Eye and Ear Hospital and subsequently at Altnagelvin Hospital, Londonderry, retiring in 1983. At an early stage he was involved in the planning of the ENT department at Altnagelvin Hospital, the first new general hospital to be built in the United Kingdom after the start of the NHS. His extended period as chairman of medical staff coincided with the worst period of civil disturbance in Northern Ireland, and he ensured that the frequent emergencies were dealt with smoothly. He was chairman of the Northern Ireland Central Medical Advisory Committee. He leaves a wife, Eustelle, and three daughters.
Disagreements still exist over the chronic fatigue syndrome
Authors: C. Shepherd
Journal: BMJ (1997)

Editor–Although the ME Association welcomes the royal colleges' unequivocal conclusion that the chronic fatigue syndrome is a genuine and disabling condition,1 we also agree that their report will “engender disagreement on both sides of the Atlantic.”2 We have no problem in accepting that the alternative name for the condition–myalgic encephalomyelitis (ME)–is pathologically incorrect, and this is a matter that we now intend to address. However, labels are important to patients as well as doctors, and support groups throughout the world …
The Complete Guide to Women's Health
Authors: Mona M. Shangold
Journal: JAMA (1983)

This book, inspiring and encouraging in tone, presents an accurate and comprehensive explanation of obstetrics, gynecology, and general medicine for women. It is easily read and understood and provides a readily available reference guide for specific problems. Its refreshing text is enhanced by representative photographs that capture both mood and spirit. Numerous tables and charts simplify concepts. Factual medical material is presented in a nonjudgmental way that avoids personal, religious, cultural, sexist, and political biases. The basic physiology underlying obstetric and gynecologic conditions is explained and the common emotional feelings that accompany them are described. The authors have identified exactly what women want to know about their conditions, which physical symptoms they may experience, how they will feel, and how they should deal with these problems. The reader will personally relate to the material and feel reassured and encouraged. The sections on selecting the right clinician, preparing for the office
Airway abnormalities at flexible bronchoscopy in patients with chronic cough
Authors: S. Decalmer, A. Woodcock, M. Greaves, M. Howe, J. Smith
Journal: European Respiratory Journal (2007)

The algorithms utilised in the diagnosis of chronic cough advocate sequential investigations and treatment trials for asthma-like syndromes, post-nasal drip and gastro-oesophageal reflux disease; however, the role of bronchoscopy is unclear. In the present authors' specialist clinic (North West Lung Centre Cough Clinic, Manchester, UK), flexible bronchoscopy is included in the diagnostic work-up of patients with chronic unexplained cough. In a retrospective review, the authors report on their experiences. Over an 18-month period, patients followed a diagnostic algorithm that included: chest radiography; pulmonary function; methacholine challenge; ear, nose and throat examination; and empirical reflux treatment. Where diagnosis remained elusive, bronchoscopy was performed. A total of 82 bronchoscopies were carried out for the sole indication of chronic cough. Patient age (mean+/-SD) was 54.9+/-11.22 yrs, with a median (range) cough duration of 5 (0.5-30) yrs. In nine (11%) subjects, a diagnosis was made on inspection or biopsy. These included seven cases of tracheobronchopathia osteochondroplastica (TPO), one case of elongated uvula and one case of endobronchial amyloidosis. All TPO patients had early changes, with a typical nodular appearance to the tracheal cartilage, without significant airway obstruction. These subtle changes could not have been predicted from less invasive procedures and would have been missed without bronchoscopy. Flexible bronchoscopy is indicated in persistent unexplained cough and may reveal contributing pathology.
Exercise‐induced bronchospasm (EIB) in relation to seasonal and perennial specific IgE in young adults
Authors: M. Brutsche, D. Britschgi, E. Dayer, J. M. Tschopp
Journal: Allergy (1995)

We investigated the relationship between exercise‐induced bronchospasm (EIB) and specific IgEs for seasonal (S‐IgE) and perennial (P‐IgE) allergens. The study, outside the main pollen season, was conducted on 289 20–year‐old soldiers, who completed a self‐administered questionnaire. A total of 289 subjects had S‐lgE and P‐IgE measured. The population was divided into subjects with (n‐ 166) and without (n = 123) history of atopic diseases (HAD). Twenty‐three of 289 subjects (8%) had asthma, 70 289 (24%) allergic rhinitis, and 92/289 (32%) atopic siblings. Measured EIB was found in 17/289 subjects (6%). They had significantly higher levels of S‐IgE and P‐IgE than those without measured EIB (respectively, P ≤0.01 and p ≤0.05). The odds ratios of having EIB were significantly increased in the entire population in relationship with an increase in both S‐IgE and P‐IgE (chi‐square test for trend 9.4 and 12.7, P ≤0.002 and 0.001. respectively). Interestingly, this highly significant relationship remained true when considering only the no HAD group (chi‐square test = 7.4 and 8.8. P ≤0.006 and 0.003, respectively). Outside the pollen season. EIB was highly related to the level of both specific seasonal and perennial IgEs in the total population and in the subjects without HAD. This suggests that even in young adults who have been asymptomatic throughout their life EIB appears to be closely linked to seasonal or perennial allergic diathesis as measured by specific IgEs.
Incidence of myocardial infarction is affected by deprivation in Buckinghamshire too
Authors: J. N Newton, S. Holton
Journal: BMJ (1997)

Editor—Caroline Morrison and colleagues report that within a relatively deprived part of north Glasgow the incidence of myocardial infarction in the poorest areas was roughly double that in the more affluent neighbourhoods.1 It may be a surprise that similar results have been obtained …
Quantitation of alpha-fetoprotein and albumin messenger RNA in human hepatocellular carcinoma
Authors: Y Niwa
Journal: Hepatology (1996)

To analyze gene expression of alpha-fetoprotein (AFP) and albumin in hepatocellular carcinoma (HCC), messenger RNAs (mRNAs) of these proteins in six human hepatoma cell lines and in 30 cases of HCC were quantitatively analyzed by competitive reverse transcription (RT) followed by polymerase chain reaction (PCR). The transcriptional levels of both AFP and albumin genes in HepG2 and Huh 7 cell lines were 1010 copies/microgram RNA, in contrast to approximately 105 copies/microgram RNA in HLE and HLF cell lines. AFP and albumin mRNA levels in three normal livers were 105 and 1010 transcripts/microgram RNA, respectively. In 30 cases with HCC AFP mRNA level in neoplasm was 10 to 105-fold enhanced as compared with that of nonneoplastic portion, and correlated with serum AFP level and tumor size (P < .01). In contrast, albumin mRNA level was not reduced in the neoplasms presenting enhanced AFP mRNA levels, indicating that AFP and albumin gene expression in situ is not necessarily mutually exclusive. Prospective analysis revealed that an increased serum AFP was shown at the time of recurrence among patients with enhanced AFP mRNA levels in neoplasm only, indicating that AFP mRNA levels in neoplasm could be a clinically predictable tool. (Hepatology 1996 Jun;23(6):1384-92)
Deaths related to methadone have doubled in Lothian
Authors: J. Greenwood, H. Zealley, D. Gorman, P. Fineron, T. Squires
Journal: BMJ (1997)

see p 1730 

Editor—In Lothian in the late 1970s injecting drug use increased rapidly. In an attempt to eradicate this the availability of needles and syringes was severely restricted. One consequence of this policy was that in the early '80s the newly arrived HIV infection spread rapidly among injecting drug users who had been deprived of injecting equipment.1

In the mid-eighties methadone began to be prescribed to drug misusers who were HIV positive, and needles and syringes …
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene
Authors: Donald A. Yergeau, Christopher J. Hetherington, Qing Wang, Pu Zhang, Arlene H. Sharpe, Michael Binder, Miguel Marín-Padilla, Daniel G. Tenen, Nancy A. Speck, Dong-Er Zhang
Journal: Nature Genetics (1997)
Implementation of the Patient-Centered Medical Home in the Veterans Health Administration
Authors: Karin M. Nelson, Christian Helfrich, Haili Sun, Paul L. Hebert, Chuan-Fen Liu, Emily Dolan, Leslie Taylor, Edwin Wong, Charles Maynard, Susan E. Hernandez, William Sanders, Ian Randall, Idamay Curtis, Gordon Schectman, Richard Stark, Stephan D. Fihn
Journal: JAMA Internal Medicine (2014)

In 2010, the Veterans Health Administration (VHA) began implementing the patient-centered medical home (PCMH) model. The Patient Aligned Care Team (PACT) initiative aims to improve health outcomes through team-based care, improved access, and care management. To track progress and evaluate outcomes at all VHA primary care clinics, we developed and validated a method to assess PCMH implementation.To create an index that measures the extent of PCMH implementation, describe variation in implementation, and examine the association between the implementation index and key outcomes.We conducted an observational study using data on more than 5.6 million veterans who received care at 913 VHA hospital-based and community-based primary care clinics and 5404 primary care staff from (1) VHA clinical and administrative databases, (2) a national patient survey administered to a weighted random sample of veterans who received outpatient care from June 1 to December 31, 2012, and (3) a survey of all VHA primary care staff in June 2012. Composite scores were constructed for 8 core domains of PACT: access, continuity, care coordination, comprehensiveness, self-management support, patient-centered care and communication, shared decision making, and team-based care.Patient satisfaction, rates of hospitalization and emergency department use, quality of care, and staff burnout.Fifty-three items were included in the PACT Implementation Progress Index (Pi2). Compared with the 87 clinics in the lowest decile of the Pi2, the 77 sites in the top decile exhibited significantly higher patient satisfaction (9.33 vs 7.53; P < .001), higher performance on 41 of 48 measures of clinical quality, lower staff burnout (Maslach Burnout Inventory emotional exhaustion subscale, 2.29 vs 2.80; P = .02), lower hospitalization rates for ambulatory care-sensitive conditions (4.42 vs 3.68 quarterly admissions for veterans 65 years or older per 1000 patients; P < .001), and lower emergency department use (188 vs 245 visits per 1000 patients; P < .001).The extent of PCMH implementation, as measured by the Pi2, was highly associated with important outcomes for both patients and providers. This measure will be used to track the effectiveness of implementing PACT over time and to elucidate the correlates of desired health outcomes.
American Academy of Orthopaedic Surgeons "Athletic training and sports medicine"
Authors: I. D. Adams
Journal: British Journal of Sports Medicine (1986)

TABLE I Electrocardiographic and echocardiographic measurements Values Normal Values ECG SV1 + RV5 49 mm < 36 mm LVPWD 2.70 cm 0.6-1.1 cm* IVSD 2.00 cm 0.6-1.1 cm* LVIDD 47 mm 37-56 mm LV Mass 763 g 180-230 g LV Mass Index 357 gm/M2
The Rush Monument.
Authors: Richard C. Newton
Journal: JAMA (1895)

Montclair, N. J., Nov. 18,1895. <h3>To the Editor:</h3> —I note among the bright paragraphs which as usual make up the column of Miscellany in your issue of the 9th inst., one relating to the monument which our friends, the homeopaths, propose to erect to the originator of their faith. I observed also that you acknowledge that the regular profession is somewhat slow in building a monument to one of the pioneers of medicine in America, Dr. Rush. I could not help thinking as I read, that it is comparatively easy to accomplish anything when the faith, enthusiasm,<i>amour propre</i>, or self-seeking of a number of people are directed in one channel or toward one object. There are many names in regular medicine beside that of Dr. Rush which ought to be perpetuated and which will be perpetuated, with or without a monument, so long as medicine is faithfully studied and
Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma
Authors: Shuhei Yoshida, Miroslaw Kornek, Naoki Ikenaga, Moritz Schmelzle, Ryota Masuzaki, Eva Csizmadia, Yan Wu, Simon C. Robson, Detlef Schuppan
Journal: Hepatology (2013)

Radiofrequency ablation (RFA) is a potentially curative therapy for hepatocellular carcinoma (HCC). However, incomplete RFA can induce accelerated invasive growth at the periphery. The mechanisms underlying the RFA-induced tumor promotion remain largely unexplored. Three human HCC cell lines were exposed to 45°C-55°C for 10 minutes, simulating the marginal zone of RFA treatment. At 5-12 days post-treatment cell proliferation, parameters of epithelial-mesenchymal transition (EMT), and activation of mitogen-activated protein kinases were analyzed. Livers from patients with viral hepatitis without and with HCC (n = 114) were examined to confirm the relevance of altered kinase patterns. In vivo tumorigenic potential of heat-treated versus untreated HCC cells was studied in nude mice. Heating to 55°C killed all HCC cells, whereas 65%-85% of cells survived 48°C-50°C, developing spindle-like morphology and expressing CD133, cytokeratin (CK)7, CK19, procollagen-α1(I), and Snail at day 5 after heat exposure, which returned to baseline at day 12. Heat-exposed HCC cells showed enhanced proliferation and prominent activation of p46-Shc (Src homology and collagen) and downstream extracellular signal-related kinase (Erk)1/2. In patients, Shc expression correlated with malignant potential and overall survival. Blocking Erk1/2 reduced proliferation and EMT-like changes of heat-treated HCC cells. Implantation of heat-exposed HEPG2 cells into nude mice induced significantly larger, more aggressive tumors than untreated cells.Sublethal heat treatment skews HCC cells toward EMT and transforms them to a progenitor-like, highly proliferative cellular phenotype in vitro and in vivo, which is driven significantly by p46Shc-Erk1/2. Suboptimal RFA accelerates HCC growth and spread by transiently inducing an EMT-like, more aggressive cellular phenotype.
Poly(3‐hydroxybutyrate‐<i>co</i>‐R‐3‐hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking
Authors: Lin‐Ping Wu, Danyang Wang, Ladan Parhamifar, Arnaldur Hall, Guo‐Qiang Chen, Seyed M. Moghimi
Journal: Advanced Healthcare Materials (2014)

A simple and highly safe poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticulate delivery system that targets different cell types is developed. A sub-cytotoxic level of polyethylenimine coat mediates universal cell targeting. Internalized nanoparticles traffic along endolysosomal compartments, endoplasmic reticulum and the Golgi complex. Nanoparticles have no detrimental effects on cell morphology and respiration. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
ABC of breast diseases: Breast cancer---epidemiology, risk factors, and genetics
Authors: K McPherson
Journal: BMJ (2000)

With 1 million new cases in the world each year, breast cancer is the commonest malignancy in women and comprises 18% of all female cancers.In the United Kingdom, where the age standardised incidence and mortality is the highest in the world, the incidence among women aged 50 approaches two per 1000 women per year, and the disease is the single commonest cause of death among women aged 40-50, accounting for about a fifth of all deaths in this age group.There are more than 14 000 deaths each year, and the incidence is increasing particularly among women aged 50-64, probably because of breast screening in this age group.Of every 1000 women aged 50, two will recently have had breast cancer diagnosed and about 15 will have had a diagnosis made before the age of 50, giving a prevalence of breast cancer of nearly 2%. Risk factors for breast cancer AgeThe incidence of breast cancer increases with age, doubling about every 10 years until the menopause, when the rate of increase slows dramatically.Compared with lung cancer, the incidence of breast cancer is higher at younger ages.In some countries there is a flattening of the age-incidence curve after the menopause. Geographical variationAge adjusted incidence and mortality for breast cancer varies by up to a factor of five between countries.The difference between Far Eastern and Western countries is diminishing but is still about fivefold.Studies of migrants from Japan to Hawaii show that the rates of breast cancer in migrants assume the rate in the host country within one or two generations, indicating that environmental factors are of greater importance than genetic factors. Worldwide incidence of cancers in women (1980)Site of cancer No of cases (1000s) % of total Breast 572 Cervix 466 Colon and rectum 286 Stomach
Comparative Genomics of the Lipid-Body-Membrane Proteins Oleosin, Caleosin and Steroleosin in Magnoliophyte, Lycophyte and Bryophyte
Authors: Pavan Umate
Journal: Genomics Proteomics & Bioinformatics (2012)

Abstract Lipid bodies store oils in the form of triacylglycerols. Oleosin, caleosin and steroleosin are unique proteins localized on the surface of lipid bodies in seed plants. This study has identified genes encoding lipid body proteins oleosin, caleosin and steroleosin in the genomes of five plants: Arabidopsis thaliana, Oryza sativa, Populus trichocarpa, Selaginella moellendorffii and Physcomitrella patens. The protein sequence alignment indicated that each oleosin protein contains a highly-conserved proline knot motif, and proline knob motif is well conserved in steroleosin proteins, while caleosin proteins possess the Dx[D/N]xDG-containing calcium-binding motifs. The identification of motifs (proline knot and knob) and conserved amino acids at active site was further supported by the sequence logos. The phylogenetic analysis revealed the presence of magnoliophyte- and bryophyte-specific subgroups. We analyzed the public microarray data for expression of oleosin, caleosin and steroleosin in Arabidopsis and rice during the vegetative and reproductive stages, or under abiotic stresses. Our results indicated that genes encoding oleosin, caleosin and steroleosin proteins were expressed predominantly in plant seeds. This work may facilitate better understanding of the members of lipid-body-membrane proteins in diverse organisms and their gene expression in model plants Arabidopsis and rice.
PRESENCE OF THORACIC AORTIC CALCIUM, AORTIC VALVULAR CALCIUM AND MITRAL ANNULAR CALCIUM AUGMENTS IDENTIFICATION OF PATIENTS WITH OBSTRUCTIVE CORONARY ARTERY DISEASE: ANALYSIS OF 1474 CONSECUTIVE PATIENTS WITHOUT KNOWN CORONARY ARTERY DISEASE UNDERGOING CORONARY CT ANGIOGRAPHY
Authors: Aryeh Shalev, Rine Nakanishi, Heidi Gransar, Louise Thomson, John Friedman, Sean Hayes, Yuka Otaki, Jamal Rana, Reza Arsanjani, James Min, Daniel Berman
Journal: Journal of the American College of Cardiology (2012)