Triamterene, A New Natruretic Agent
Authors: ARCHER P. CROSLEY
Journal: Annals of Internal Medicine (1962)

Article1 February 1962Triamterene, A New Natruretic AgentPreliminary Observations in ManARCHER P. CROSLEY JR., M.D., F.A.C.P., LOLITA M. RONQUILLO, M.D., WILBUR H. STRICKLAND, M.D., FRED ALEXANDER, M.D.ARCHER P. CROSLEY JR., M.D., F.A.C.P., LOLITA M. RONQUILLO, M.D., WILBUR H. STRICKLAND, M.D., FRED ALEXANDER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-241 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptObservations in rats and dogs by Wiebelhaus and colleagues (1) demonstrated that triamterene (SK&F No. 8542) (Figure 1) possessed antimineralo-corticoid activity. Furthermore, the site of such action appeared to be at the renal tubular level. Following 30-day toxicity studies by Saunders (2) in the same animal species at dose levels between five milligrams per kilogram of body weight and 40 milligrams per kilogram, which revealed no gross or microscopic changes in any organ system, it was decided to test the possible utility and toxicity of the agent in man. The following data are the results of these investigations.METHODSThe...References1. WIEBELHAUSWEINSTOCKBRENNANSOSNOWSKILARSEN VDJFTGTJ: A potent, non-steroidal orally active antagonist of aldosterone. Fed. Proc. 20: 409, 1961. MedlineGoogle Scholar2. SAUNDERS LZ: Subacute toxicity studies of SK&F No. 8542. Unpublished data. Google Scholar3. BRODSIROTA JJH: The renal clearance of endogenous "creatinine" in man. J. Clin. Invest. 27: 645, 1948. CrossrefMedlineGoogle Scholar4. VAN SLYKENEIL DDJM: The determination of gases in blood and other solutions by vacuum excretion and manometric measurement. J. Biol. Chem. 61: 523, 1924. CrossrefGoogle Scholar5. MEEKERWAGNER EWEC: Titration of ammonia in presence of boric acid. Macroand micro-Kjeldahl procedures. Industr. Eng. Chem. 5: 396, 1933. Google Scholar6. SILBERPORTER RHCC: Determinations of 17,21 dihydroxy-20-ketosteroids in urine and plasma, in Methods of Biochemical Analysis, vol. 4, ed. by Click, D., Interscience Publishers, New York, 1957, p. 139. Google Scholar7. JOHNSEN SC: Fractionation of urinary 17-ketosteroids. Acta Endocr. 21: 127, 1956. MedlineGoogle Scholar8. GOLDRINGCHASIS WH: Hypertension, The Commonwealth Fund, New York, 1944. Google Scholar9. HARRISON HE: A modification of the diphenylamine method for determination of inulin. Proc. Soc. Exp. Biol. Med. 49: 111, 1942. CrossrefGoogle Scholar10. SMITHFINKELSTEINALIMINOSACRAWFORDGRABER HWNLBM: The renal clearance of substituted hippuric acid derivatives and other aromatic acids in dog and man. J. Clin. Invest. 24: 388, 1945. CrossrefMedlineGoogle Scholar11. EDMONDS CJ: An aldosterone antagonist and diuretics in the treatment of chronic edema and ascites. Lancet 1: 509, 1960. CrossrefMedlineGoogle Scholar12. ROWE GG: Personal communication. Google Scholar13. CROSLEYCULLENWHITEFREEMANCRUMPTONCASTILLOROWE APRCDJFCWCAGG: Studies of the mechanism of action of chlorothiazide in cardiac and renal diseases. J. Lab. Clin. Med. 55: 182, 1960. MedlineGoogle Scholar14. SONNENBLICKCANNONLARAGH EHPJJH: The nature of the action of intravenous aldosterone: Evidence for a role of the hormone in urinary dilution. J. Clin. Invest. 40: 903, 1961. CrossrefMedlineGoogle Scholar15. LARAGHREILLYSTITESANGERS JHEBTBM: Pteridine compound as an inhibitor of aldosterone action in man. Fed. Proc. 20: 410, 1961. Google Scholar16. RECTORCLAPP FCJR: The mechanism of renal chloride reabsorption. J. Clin. Invest. 40: 1075, 1961. Google Scholar17. CROSLEYRONQUILLOALEXANDER APLF: The combined effects of triamterene and benzothiadiazine derivatives. Unpublished data. Google Scholar18. CROSLEYRONQUILLOSTRICKLANDALEXANDER APLWHF: Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARCHER P. CROSLEYJR., M.D., F.A.C.P.; LOLITA M. RONQUILLO, M.D.; WILBUR H. STRICKLAND, M.D.; FRED ALEXANDER, M.D.Affiliations: Philadelphia, PennsylvaniaFrom the Departments of Medicine and Clinical Research, Mercy-Douglass Hospital, Philadelphia, Pennsylvania.Requests for reprints should be addressed to Archer P. Crosley, Jr., M.D., Department of Clinical Research, Mercy-Douglass Hospital, 5000 Woodland Avenue, Philadelphia 43, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySimultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological ChaperonesDiuretic and Uricosuric AgentsEffects of Diuretics on Renal FunctionThe effects of antihypertensive drugs on glucose intolerance in hypertensive nondiabetics and diabeticsAdverse Effects of Antihypertensive Drug Therapy on Glucose IntoleranceZur Chemolumineszenz von TriamterenDie Anwendung von Diuretika bei der akuten und chronischen HerzinsuffizienzThe pharmacology of diuretics1 Aspects of the Pharmacology of Passive Ion Transfer Across Cell MembranesREFERENCESCombination of Bendroflumethiazide and Triamterene in the Treatment of Hypostatic EdemaPseudo-AntialdosteroneSynthesis of 1,3-dimethyl-7-amino-6-substituted-2,4-pteridinedionesTreatment of the Patient With Refractory Heart FailureStimulation by pteridines of the uptake of amethopterin by human lymphocytesSERUM ELECTROLYTE CHANGES DURING LONG-TERM TREATMENT WITH AMILORIDE HYDROCHLORIDE (MK-870)USE OF A DIURETIC COMBINATION OF TRIAMTERENE AND HYDROCHLOROTHIAZIDE IN ELDERLY PATIENTSALDOSTERONE ANTAGONISTS AND TRIAMTERENETHE RENAL REGULATION OF SODIUM AND POTASSIUM IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF) AND THE EFFECT OF DIURETICS ON THE EXCRETION OF THESE IONSHyperkalemic Effects of TriamtereneALLEN B. COHEN, M.D.MODERN DIURETIC THERAPY IN GERIATRIC PRACTICETrial of a triamterene-benzthiazide combination (Dytide)Triamterene: Clinical studies in arterial hypertensionCombination of Triamterene and Hydrochlorothiazide in the Treatment of Congestive Heart FailureDiuretic therapy. Part VIII. Triamterene as a diureticMetabolic Studies with the Diuretic Triamterene in Patients with Cirrhosis and AscitesACTION OF TRIAMTERENEImidazo[4,5-d]pyridazines. III. The Synthesis of 2-phenylimidazo [4,5-d]-pyridazinesTRIAMTERENE IN THE TREATMENT OF MYASTHENIA GRAVISTriamterene in the Treatment of Ascites in Hepatic Cirrhosis�ber die antihypertensive Wirkung der elektrolytwirksamen Substanzen Isobutylhydrochlorothiazid, Spironolactone und TriamtereneOBSERVATIONS ON TRIAMTERENE-A NEW DIURETICA clinical evaluation of a combination of two oral diuretics—triamterene and benzthiazideAldosterone AntagonistsUntersuchungen zur Lokalisation des Angriffspunktes von 2,4,7-Triamino-6-Phenyl-Pteridin am Nephron 1 February 1962Volume 56, Issue 2 Page: 241-251 Keywords Body weight Drugs Excretion Hospital medicine Toxic agents Toxicity ePublished: 1 December 2008 Issue Published: 1 February 1962 PDF downloadLoading ...