Pancreatitis, Hyperlipidemia, and Pregnancy in Two Sisters
Authors: Stanley H. Hsia
Journal: Annals of Internal Medicine (1997)

Letters1 January 1997Pancreatitis, Hyperlipidemia, and Pregnancy in Two SistersStanley H. Hsia, MD, Philip W. Connelly, PhD, and Robert A. Hegele, MDStanley H. Hsia, MDSt. Michael's Hospital; University of Toronto; Toronto, Ontario, CanadaSearch for more papers by this author, Philip W. Connelly, PhDSt. Michael's Hospital; University of Toronto; Toronto, Ontario, CanadaSearch for more papers by this author, and Robert A. Hegele, MDSt. Michael's Hospital; University of Toronto; Toronto, Ontario, CanadaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-1-199701010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with great interest Kielson and colleagues' report [1] of severe hypertriglyceridemia and pancreatitis associated with pregnancy and the administration of cholestyramine in two sisters heterozygous for the missense mutation Gly→Glu at position 188 of the lipoprotein lipase (LPL) gene. The medical care and subsequent molecular characterization of these sisters were excellent. However, both homozygosity and heterozygosity for this same mutation have been reported to be associated with pregnancy-induced pancreatitis [2, 3]. The mechanism was presumed to be an estrogen-related exacerbation of a preexisting lipolytic defect of triglyceride clearance. However, this mutation alone clearly cannot account ...References1. Kielson LM, Vary CP, Sprecher DL, Renfrew R. Hyperlipidemia and pancreatitis during pregnancy in two sisters with a mutation in the lipoprotein lipase gene. Ann Intern Med. 1996; 124:425-8. Google Scholar2. Hegele RA, Little JA, Connelly PW. Heterozygosity for mutant lipoprotein lipase in pregnancy-induced hypertriglyceridemia [Abstract]. Clin Res. 1991; 39:665A. Google Scholar3. Sanderson SL, Iverius PH, Wilson DE. Successful hyperlipemic pregnancy. JAMA. 1991; 265:1858-60. Google Scholar4. Hsia SH, Connelly PW, Hegele RA. Successful outcome in severe pregnancy-associated hyperlipemia: a case report and literature review. Am J Med Sci. 1995; 309:213-8. Google Scholar5. Ma Y, Ooi TC, Liu MS, Zhang H, McPherson R, Edwards AL, et al. High frequency of mutations in the human lipoprotein lipase gene in pregnancy-induced chylomicronemia: possible association with apolipoprotein E2 isoform. J Lipid Res. 1994; 35:1066-75. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. Michael's Hospital; University of Toronto; Toronto, Ontario, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcute pancreatitis associated with severe hypertriglyceridaemia; A retrospective cohort studyEffect of admission hypertriglyceridemia on the episodes of severe acute pancreatitisHypertriglyceridemia-induced pancreatitis: A case-based review 1 January 1997Volume 126, Issue 1Page: 88-89KeywordsApolipoproteinsHeparinHeterozygosityHomozygosityHyperlipidemiaLipasesLipoproteinsPancreatitisPhenotypesPregnancy Issue Published: 1 January 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...