tbuckley/cabot-search huggingface dataset:
P17.31 * LONG-TERM SURVIVAL OF GLIOBLASTOMA PATIENTS: WHICH CLINICAL AND MOLECULAR CORRELATION?
Authors: A. Fabi, V. Villani, A. Pace, V. Antonello, M. Maschio, C. M. Carapella, M. A. Carosi, F. Cognetti, L. Marucci, I. Terrenato
Journal: Neuro-Oncology (2014)

BACKGROUND: Long-term survivors of glioblastoma (GBM) are rare. Patients with GBM have a median survival of less than 1 year. About 4% of patients survive beyond 3 years. Several variables besides tumor size and location determine a patient's survival chances: age at diagnosis, where younger patients often receive more aggressive treatment that is multimodal; functional status, which has a significant negative correlation with age; histologic and genetic markers. METHODS: Despite extensive clinical trials, prediction of clinical outcome for individual patients has remained an elusive goal. In search of factors or predictors of long-term survival, we conducted a retrospective analysis of GBM patient with a survival beyond 30 months in order to evaluate clinical and molecolar prognostic factors. Kaplan-Meier method was applied to estimate time to relapse and survival. The log-rank test was used to compare subgroups. RESULTS: A total of 27 GBM patients were studied. Twenty out of 27 (74%) were males. Median age was 53 years (29-74 years). Twenty-five (93%) patients had a total resection. All patients but one were received radiotherapy combined to Temozolomide (TMZ) as early treatment followed by a median cycle of TMZ of 16 months (1-53 months). The median number of previous chemotherapy lines was 2 (0-4) and 13 (48%) patients received second surgery for relapsed disease. Information about MGMT methylation was, to date, available for 13 patients out of 27 (48%) and 10 out of these were methylated. A median time of first relapsed was 21 months (95% confidence interval (95%CI: 13-28 months). Median survival was 40 months (95%CI: 35-44 months). Better survival was showed in patients younger at diagnosis (< 50 years) (p = 0.028) and in patients who were able to receive more than two lines of treatment (p < 0.0001). CONCLUSIONS: The study confirms, in an homogenous series of patients, that positive clinical prognostic factors for increased survival of GBM patients are the age and more than one previous chemotherapy. These finding has a major impact on clinical practice, as an incentive to treat patients beyond the first line when they have the appropriate clinical conditions. Molecular correlations (MGMT, IDH1) with long-survival will be presented to the meeting.
A patient with fever and an abnormal roentgenogram
Authors: RI Cohen, LJ Rossoff
Journal: European Respiratory Journal (1994)

A 38 year old white woman was admitted to hospital with a one week history of right leg cellulitis, that had progressed despite treatment with dicloxacillin, 500 mg orally, 4 times daily. She had been diagnosed as having acquired immune deficiency syndrome (AIDS) 4 years prior to admission, with sexual contact being the risk factor as there was no history of intravenous drug abuse or transfusions. Two years prior to admission, she developed immune thrombocytopenic purpura requiring splenectomy and the continued use of oral steroids. Four months prior to admission, she was diagnosed as having non-Hodgkins lymphoma and received two courses of chemotherapy with good response
Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: A prospective cohort study
Authors: Lluis Castells, Antoni Rimola, Christian Manzardo, Andrés Valdivieso, José Luis Montero, Rafael Barcena, Manuel Abradelo, Xavier Xiol, Victoria Aguilera, Magdalena Salcedo, Manuel Rodriguez, Carmen Bernal, Francisco Suarez, Antonio Antela, Sergio Olivares, Santos del Campo, Montserrat Laguno, José R. Fernandez, Gloria de la Rosa, Fernando Agüero, Iñaki Perez, Juan González-García, Juan I. Esteban-Mur, Jose M. Miro
Journal: Journal of Hepatology (2014)
The Q-T Interval in Chronic Cor Pulmonale
Authors: JAMES K. ALEXANDER, M. IRENÉ FERRER, RÉJANE M. HARVEY, ANDRÉ COURNAND
Journal: Circulation (1951)

In 13 patients in whom the diagnosis of chronic cor pulmonale was made after careful physiologic studies, the Q-T interval was found to be within normal limits regardless of the presence or absence of cardiac failure. The finding is in sharp contrast to the prolongation of this interval in the more common types of heart disease, as exemplified by a group of 14 patients with hypertensive and arteriosclerotic heart disease. Measurement of the Q-T interval therefore may be useful in differentiating pure chronic cor pulmonale from other types of heart disease with congestive failure.
Natural progesterone and antihypertensive action.
Authors: P B Rylance, M Brincat, K Lafferty, J C De Trafford, S Brincat, V Parsons, J W Studd
Journal: BMJ (1985)

In a placebo controlled, double blind crossover study natural progesterone was given by mouth, in increasing doses, to six men and four postmenopausal women with mild to moderate hypertension who were not receiving any other antihypertensive drugs. When compared with values recorded before treatment and during administration of placebo progesterone caused a significant reduction in blood pressure, suggesting that progesterone has an antihypertensive action rather than a hypertensive one as has been previously thought. This possible protective effect of progesterone should be investigated further.
Diagnosis of Smoldering Multiple Myeloma
Authors: S. Vincent Rajkumar, Dirk Larson, Robert A. Kyle
Journal: New England Journal of Medicine (2011)

Curfman et al. state that only 3% of physicians have elected to participate in the Physician Data Restriction Program of the American Medical Association (AMA) and thus remove their prescribing information from that database.They state that the Electronic Privacy Information Center attributes this low rate to the possibility that physicians are not aware of the program.When I "opted out" some years ago, I recall the process as being a difficult one.Thus, among the possible reasons that physicians may not be "opting out," we should add that the process created by the AMA, given the association's commercial interest in having as complete a database as possible, is a difficult one.
Suggested Procedure for Performance of Autopsies on Radioactive Cadavers
Authors: Russell F. Gowing, Egilda DeAmicis
Journal: New England Journal of Medicine (1954)

THE increasing use of radioisotopes in medicine has resulted in many problems in protection of personnel associated with radioactive patients. An additional protection problem arises when a patient who has received a large internal therapeutic dose of radioisotope dies. If autopsy permission is granted, special procedures and precautions should be outlined for the pathologist. Recently (October 26, 1953) the Na>tional Bureau of Standards1 issued recommendations in a handbook.To provide a practical working procedure for this hospital the procedure described below has been established for the performance of autopsies on cadavers containing radiogold (Au-198). It is based largely on information . . .
RBRVS: Objections to Maloney, I
Authors: William Hsiao
Journal: JAMA (1992)

DR MALONEY'S<sup>1</sup><i>JAMA</i>article entitled "A Critical Analysis of the Resource-Based Relative Value Scale" is a good illustration of the aphorism that statistics do not lie, but people misuse them. Dr Maloney divided the annual net income by the total number of hours worked for various specialties and concluded that, under the resource-based relative value scale (RBRVS), surgical services measured on an hourly basis would be paid less than evaluation and management (E/M) services. Dr Maloney obtained this erroneous conclusion because he used incorrect data and employed seriously flawed methods. He then made unwarranted generalizations and presented a global assessment of the RBRVS that is wholly incorrect. We concur with the critique of Dr Maloney's methods and data presented by Radecki et al.<sup>2</sup>The data from Mendenhall's<sup>3</sup>study regarding weekly hours worked, on which many of Dr Maloney's calculations are based, were gathered in the late 1970s
TCT-822 Computed tomography evaluation prior to CoreValve implantation predicts postprocedural aortic regurgitation
Authors: Sabine Bleiziffer, Domenico Mazzitelli, Anke Opitz, Yacine Elhmidi, Benedikt Mayr, Patrick Mayr, Rudiger Lange, Nicolo Piazza
Journal: Journal of the American College of Cardiology (2012)
On the Take: How Medicine's Complicity with Big Business Can Endanger Your Health
Authors: Howard Waitzkin
Journal: Annals of Internal Medicine (2006)

Medical Writings: Book Notes7 November 2006On the Take: How Medicine's Complicity with Big Business Can Endanger Your HealthHoward Waitzkin, MD, PhDHoward Waitzkin, MD, PhDFrom University of New Mexico, Albuquerque, New Mexico.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-9-200611070-00025 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Kassirer JP. 272 pages. New York: Oxford Univ Pr; 2005. $14.95. ISBN 0195300041. Order at www.oup.com.Fields of medicine: Medical ethics and economics.Format: Paperback book.Audience: Patients; the general public; and concerned physicians, residents, and medical students.Purpose: To clarify financial conflicts of interest for physicians, teaching institutions, and professional organizations that receive compensation from the pharmaceutical industry.Content: Written by a professor of internal medicine and former editor of The New England Journal of Medicine, this book provides convincing evidence of the medical profession's complicity with the pharmaceutical industry. Financial conflicts of interest lead to distortions of medical ... Author, Article, and Disclosure InformationAffiliations: From University of New Mexico, Albuquerque, New Mexico. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 November 2006Volume 145, Issue 9Page: 712KeywordsConflicts of interestDrug regulationDrugsHealth information technologyMedical educationMedical ethicsSoftware tools ePublished: 7 November 2006 Issue Published: 7 November 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.Loading ...
Factitious Hypoglycemia
Authors: John A. Scarlett, Mary E. Mako, Arthur H. Rubenstein, Petra M. Blix, Jose Goldman, David L. Horwitz, Howard Tager, Jonathan B. Jaspan, Melvin R. Stjernholm, Jerrold M. Olefsky
Journal: New England Journal of Medicine (1977)

In seven patients with factitious hypoglycemia due to the surreptitious injection of insulin, we made the diagnosis by measurements of plasma insulin and C-peptide immunoreactivity (in seven patients), facilitated by the finding of circulating insulin-binding antibodies (in two patients). The simultaneous demonstration of low plasma glucose, high immunoreactive insulin and suppressed C-peptide immunoreactivity represents a triad of results pathognomonic of exogenous insulin administration. Determination of plasma free C-peptide and free insulin permitted patients with high titers of insulin antibodies, including those with a history of insulin-treated diabetes, to be studied and diagnosed in a way similar to that in subjects who had no circulating insulin antibodies.
Usefulness of a gazetteer of general practice
Authors: B L E C Reedy
Journal: BMJ (1975)

An earlier paper' described how a gazetteer of information about 55 general practices was sent to all the hospital, area health authority, and social services staff in Aylesbury to encourage communication with the practices.Experiments to aid communications in the NHS have had equivocal results,2-4 and an attempt to measure the use of the gazetteer seemed essential.
3-DIMENSIONAL SPECKLE TRACKING IMAGING FOR LEFT VENTRICULAR ROTATION MEASUREMENT: AN IN VITRO VALIDATION STUDY
Authors: David J. Sahn, Zhiwen Zhou, Li Xiong, Muhammad Ashraf, Da-Yi Hu, Xaio-Nan Dai, Ya-Wei Xu, Berkley Cameron, Bill Kenny
Journal: Journal of the American College of Cardiology (2010)
Retinitis Pigmentosa, Hypertension, and Uraemia in Werner's Syndrome
Authors: A. Valero, B. Gellei
Journal: BMJ (1960)

1956), and it has been suggested that there is a separate exophthalmos-producing substance (E.P.S.).The physiological role of this substance is puzzling and its assay is difficult.It has been claimed that E.P.S. can be separated chemically from T.S.H. (Dobyns and Steel- man, 1953), that it can produce exophthalmos experimentally, and that excess of it in the serum of patients is correlated with exophthalmos (Dobyns and Wilson, 1954; Brunish, 1958).It has yet to be established that E.P.S. or any other substance is present in excess in the serum of patients who develop pretibial myxoedema and later acropachy.The concept that excess of a pituitary hormone produces change in certain parts of a target organ, the skin, is not yet proved and is unhelpful as a basis for therapy.At present one can only say that pretibial myxoedema in the skin is one of several localized disorders, perhaps essentially similar, which may appear in Graves's disease under certain circum- stances as yet obscure. SummaryIn 23 patients with pretibial myxoedema the appear- ance and behaviour of the lesions, and their relationship with hyperthyroidism, are described.Minor pretibial lesions are not uncommon; they usually soon resolve after hyperthyroidism has been controlled.Severe pretibial myxoedema, when it develops, tends to do so after cure of hyperthyroidism and in association with severe exophthalmos.When the lesions become extensive they persist and are resistant to treatment.I thank the physicians of St. Thomas's Hospital who have allowed me to describe patients under their care.
Axl/Phosphatidylinositol 3-Kinase Signaling Inhibits Mineral Deposition by Vascular Smooth Muscle Cells
Authors: Georgina D.M. Collett, Andrew P. Sage, John Paul Kirton, M. Yvonne Alexander, Andrew P. Gilmore, Ann E. Canfield
Journal: Circulation Research (2007)

The calcification of blood vessels correlates with increased morbidity and mortality in patients with atherosclerosis, diabetes, and end-stage kidney disease. The receptor tyrosine kinase Axl is emerging as an important regulator of adult mammalian physiology and pathology. This study tests the hypothesis that Axl prevents the deposition of a calcified matrix by vascular smooth muscle cells (VSMCs) and that this occurs via the phosphatidylinositol 3-kinase (PI3K) signaling pathway. First, we demonstrate that Axl is expressed and phosphorylated in confluent VSMCs and that its expression is markedly downregulated as these cells calcify their matrix. Second, we demonstrate that overexpression of wild-type Axl, using recombinant adenoviruses, enhances Axl phosphorylation and downstream signaling via PI3K and Akt. Furthermore, overexpression of Axl significantly inhibits mineral deposition by VSMCs, as assessed by alizarin red staining and (45)Ca accumulation. Third, the addition of a PI3K inhibitor, wortmannin, negates the inhibition of mineralization by overexpression of wild-type Axl, suggesting that activation of downstream signaling via PI3K is crucial for its inhibitory activity. In contrast, Axl-mediated signaling is not enhanced by overexpression of kinase-dead Axl and mineralization is accelerated, although beta-glycerophosphate is still required for this effect. Finally, the caspase inhibitor zVAD.fmk attenuates the increased mineralization induced by kinase-dead Axl, suggesting that kinase-dead Axl stimulates mineralization by inhibiting the antiapoptotic effect of endogenous Axl. Together, these results demonstrate that signaling through Axl inhibits vascular calcification in vitro and suggest that therapeutics targeting this receptor may open up new avenues for the prevention of vascular calcification in vivo.
NICE responds to criticism of hypertension guidelines
Authors: Peter Littlejohns, Gillian Leng, Andrea Sutcliffe
Journal: BMJ (2005)

Save the FDAEditor-Abbasi asks whether drug regulation is failing. 1 The US Food and Drug Administration (FDA) performs a thankless task.Patients want new drugs available immediately and agitate to accomplish this.Patients also wish medicines to be guaranteed safe, and blame the FDA when toxicity leads to a drug's withdrawal.Clinical scientists complain that the FDA obstructs their investigations.Pharmaceutical companies see the FDA as an adversary, not a protector.Practising in the USA for 20 years, I encountered many FDA agents.A few revered regulations for their own sake.Such people are irksome, but without strict oversight valueless and toxic agents would be marketed.A prime example is Laetrile (laevo-mandelonitrile-beta-glucuronoside), a useless and poisonous drug promoted for cancer treatment.The FDA, supported by the National Cancer Institute, successfully resisted extreme public pressure to allow its marketing, saving many lives and a multimillion dollar fraud.The FDA faces serious accusations.Attempting to suppress David Graham's whistleblowing on rofecoxib assaults scientific honesty. 2 3 The FDA's refusal to allow non-prescription sales of emergency contraception indicates unacceptable political pressure from the religious right.Unduly close relations between the FDA and pharmaceutical companies may lead to premature marketing approvals.How should the FDA be saved?Firstly, officials ordering withdrawal of a drug should be independent of those who approve marketing.Secondly, making the FDA a quango would protect from political pressures.Thirdly, conflicts of interest involving FDA employees and consultants must be rigorously scrutinised, even more severely than editors scrutinise the interests of contributors.The UK's Medicines and Healthcare products Regulatory Agency is accused of proindustry bias.Housecleaning there and at the FDA will benefit patients, doctors, and the pharmaceutical industry itself.
Training in Suicide Prevention for Professional and Community Agents
Authors: NORMAN L. FARBEROW
Journal: American Journal of Psychiatry (1969)

The Los Angeles Suicide Prevention Center has been training mental health professionals, semiprofessionals (primarily graduate students in mental health disciplines), nonprofessional volunteers, and various community groups for about a decade. The author describes the various types of training offered and notes that a primary objective for both public and professionals is to diminish the taboo aspects of suicide.
Parents With Cancer: Who’s Looking After the Children?
Authors: Paula K. Rauch, Anna C. Muriel, Ned H. Cassem
Journal: Journal of Clinical Oncology (2002)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.21.4399 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12409342 Parents With Cancer: Who's Looking After the Children? Paula K. RauchxPaula K. RauchSearch for articles by this author , Anna C. MurielxAnna C. MurielSearch for articles by this author , Ned H. CassemxNed H. CassemSearch for articles by this author Show More From the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA. https://doi.org/10.1200/JCO.2002.20.21.4399 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
THE REACTIONS BETWEEN BACTERIA AND ANIMAL TISSUES UNDER CONDITIONS OF ARTIFICIAL CULTIVATION
Authors: Henry Field Smyth
Journal: The Journal of Experimental Medicine (1916)

These results seem to indicate that many bacteria may be utilized by tissue cells as food for growth or may contain a substance or substances stimulating cell growth or multiplication. This substance is stable and is not destroyed by heating to 100° C. or by long standing. With Micrococcus aureus this action is often neutralized or overcome by a substance inhibitory to growth. The nature of these substances has not yet been determined, though several attempts along this line were made by endeavoring to split the typhoid bacterial substance according to the method of Vaughan See PDF for Structure and testing the poisonous and non-poisonous residues separately. However, at the time too little bacterial substance was used to obtain enough end-products to be of much use, and the products so obtained prevented the plasma from coagulating. Even in the uncoagulated plasma there appeared to be an increase of cells in the cultures with the non-poisonous residue. The author hopes to be able to repeat these tests with split products at a later time when more bacterial substance is available, with the hope of obtaining more definite results.
The immune response in chronic hepatitis B virus infection: The “Core” of the problem?
Authors: James R. Baker
Journal: Hepatology (1992)

Individuals with chronic hepatitis B virus (HBV) infection are generally divided into asymptomatic healthy carriers and patients with chronic liver disease. Several studies have suggested that the hepatitis B core antigen could be an immunological target of cytotoxic T lymphocytes (CTL). To investigate the possible pressure site from CTL, the entire core region of HBV DNA was sequenced in 30 subjects (10 asymptomatic healthy carriers and 20 patients with chronic liver disease). No significant changes in the nucleotide sequence and deduced amino acid residue were noted in the 10 healthy carriers. In contrast, a cluster of changes in a small segment of 18 amino acids (codons 84-101 from the start of the core gene) was found in 15 of the 20 chronic liver disease patients. All these 15 patients had advanced liver diseases (chronic active hepatitis and cirrhosis), whereas only mild liver disease (chronic persistent hepatitis) was found in the five patients without mutations. These data suggest that the region with mutation clustering is the major target of CTL, and that the mutations evolve under the pressure of immune selection.