tbuckley/cabot-search huggingface dataset:
Studies on the evaluation of the toxicity of various salts of lead, manganese, platinum, and palladium.
Authors: D J Holbrook, M E Washington, H B Leake, P E Brubaker
Journal: Environmental Health Perspectives (1975)

Preliminary studies have been conducted on various parameters in order to assess the possible and relative toxicities of a number of metallic salts. Upon oral administration in lethal-dose experiments, two soluble Pt4+ salts were more toxic than the other salts tested. Following intraperiotneal injection in lethal-dose experiments, PbCl2 was less toxic than several of the soluble or partially soluble salts of Pt4+, Pd2+, and Mn2+. An intake of a total of approximately 250 mg of Pt4+ per rat in the drinking fluid over a 30-day interval did not affect the activities of aniline hydroxylase and aminopyrine demethylase in rat liver microsomes. In rats receiving soluble Pt4+ salts in the drinking fluid, the highest concentration of Pt was found in the kidney and an appreciiable concentration was found in the liver.
Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus
Authors: Jason W Bauer, Emily C Baechler, Michelle Petri, Franak M Batliwalla, Dianna Crawford, Ward A Ortmann, Karl J Espe, Wentian Li, Dhavalkumar D Patel, Peter K Gregersen, Timothy W Behrens
Journal: PLoS Medicine (2006)

Background Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence indicates a role for type I interferon (IFN) in SLE pathogenesis; however, the downstream effects of IFN pathway activation are not well understood. Here we test the hypothesis that type I IFN-regulated proteins are present in the serum of SLE patients and correlate with disease activity. Methods and Findings We performed a comprehensive survey of the serologic proteome in human SLE and identified dysregulated levels of 30 cytokines, chemokines, growth factors, and soluble receptors. Particularly striking was the highly coordinated up-regulation of 12 inflammatory and/or homeostatic chemokines, molecules that direct the movement of leukocytes in the body. Most of the identified chemokines were inducible by type I IFN, and their levels correlated strongly with clinical and laboratory measures of disease activity. Conclusions These data suggest that severely disrupted chemokine gradients may contribute to the systemic autoimmunity observed in human SLE. Furthermore, the levels of serum chemokines may serve as convenient biomarkers for disease activity in lupus.
Effects of Progressive Muscle Relaxation Training on Anxiety and Depression in Patients Enrolled in an Outpatient Pulmonary Rehabilitation Program
Authors: Sermsak Lolak, Gerilynn L. Connors, Michael J. Sheridan, Thomas N. Wise
Journal: Psychotherapy and Psychosomatics (2008)

This prospective, randomized controlled trial examined the effect of progressive muscle relaxation (PMR) training on anxiety and depression in patients with chronic breathing disorders receiving pulmonary rehabilitation (PR).Eighty-three subjects with chronic breathing disorders entering the 8-week PR program were randomly assigned to a standard care or intervention group. The standard program included 2 days per week of exercise, education and psychosocial support delivered by a multidisciplinary team. The intervention group received additional sessions of PMR training using a prerecorded tape for 25 min/week during weeks 2-8. Primary outcome measures were levels of anxiety and depression evaluated by the Hospital Anxiety and Depression Scale.For anxiety, there was an overall significant improvement within each group over time (p < 0.0001). There was no statistically significant group-time interaction (p = 0.17) and no statistically significant difference between the groups (p = 0.22), despite lower scores for every time point in the PMR group. For depression, there was an overall significant improvement within each group over time (p < 0.0001). Although the difference between the groups (p = 0.09) and group-time interaction (p = 0.07) did not reach statistical significance, the results again favored the PMR group for weeks 5-8. Depression scores were lower for the PMR throughout weeks 1-8.PR is effective in reducing anxiety and depressive level in chronic lung patients. Our findings suggest that adding structured PMR training to a well-established PR program may not confer additional benefit in the further reduction of anxiety and depression in patients receiving PR.
Biochemical and Immunological Properties of Human Terminal Deoxynucleotidyl Transferase Purified from Blasts of Acute Lymphoblastic and Chronic Myelogenous Leukemia
Authors: Martin R. Deibel, Mary Sue Coleman, Karen Acree, John J. Hutton
Journal: Journal of Clinical Investigation (1981)

Terminal deoxynucleotidyl transferase was purified to homogeneity from the blasts of eight patients with leukemia and compared with purified transferase from normal human and calf thymus. In two cases phenylmethanesulfonylfluoride was added during purification to reduce proteolysis. Comparative kinetic analyses of the purified enzymes indicated no differences in catalytic properties. There was substantial variation in the molecular structure of terminal transferase on denaturing polyacrylamide gels: (a) a protein that migrated as a single polypeptide with Mr = 62,000 was isolated from two patients with acute lymphoblastic leukemia and from MOLT-4 cells; (b) a protein that migrated as a single polypeptide with Mr = 42,500 was isolated from two patients with acute lymphoblastic leukemia; (c) a protein that migrated as a single polypeptide with Mr = 42,500 was isolated from two patients with chronic myelogenous leukemia in blast crisis; (d) a protein that migrated as two non-identical subunits of Mr = 27,000 and 10,000, respectively, was isolated from two additional patients with chronic myelogenous leukemia in blast crisis. The subunit structure of d is characteristic of the homogeneous enzymes purified from human and calf thymus. Neutralizing and precipitating antibodies to terminal transferase from human lymphoblasts and calf thymus have been produced in rabbits and goats. Antisera directed against either human or calf antigens neutralize enzymatic activity and precipitate all forms of human terminal transferase. The multiple human forms give reactions of antigenic identity by immunodiffusion, but differ antigenically from the calf enzyme. The multiple forms of terminal transferase could represent physiological processing, artifactual degradation, or isozymes coded by several genes.
Release of VA Records to Private Physicians
Authors: Joseph H. McNinch
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Kenneth K. Hazlet, MD, of Dubuque, Iowa, corresponded with Donovan F. Ward, MD (President of the American Medical Association) on Oct 24, 1964, in regard to difficulty encountered by the referring private physician in obtaining, automatically, a clinical report from a Veterans Administration medical facility when the patient is returned to his home community. This correspondence was referred by Dr. Ward to the Department of Governmental Medical Services, Division of Environmental Medicine and Medical Services of the AMA, with instructions to attempt to resolve this matter with the VA. A letter was directed to Joseph H. McNinch, MD, Chief Medical Director, requesting information and assistance on the problem. Dr. McNinch replied that "the Department of Medicine and Surgery of the Veterans Administration was planning to issue instructions to hospitals and clinics relative to the release of medical information to private physicians." On Jan 11, 1965, Veterans Administration,
The midcycle increase in ovarian glucose uptake is associated with enhanced expression of glucose transporter 3. Possible role for interleukin-1, a putative intermediary in the ovulatory process.
Authors: S Kol, I Ben-Shlomo, K Ruutiainen, M Ando, T M Davies-Hill, R M Rohan, I A Simpson, E Y Adashi
Journal: Journal of Clinical Investigation (1997)

This study characterizes the rat ovary as a site of hormonally dependent glucose transporter (Glut) expression, and explores the potential role of interleukin (IL)-1, a putative intermediary in the ovulatory process, in this regard. Molecular probing throughout a simulated estrous cycle revealed a significant surge in ovarian Glut3 (but not Glut1) expression at the time of ovulation. Treatment of cultured whole ovarian dispersates from immature rats with IL-1beta resulted in upregulation of the relative abundance of the Glut1 (4.5-fold) and Glut3 (3.5-fold) proteins as determined by Western blot analysis. Other members of the Glut family (i.e., Gluts 2, 4, and 5) remained undetectable. The ability of IL-1 to upregulate Glut1 and Glut3 transcripts proved time-, dose-, nitric oxide-, and protein biosynthesis-dependent but glucose independent. Other ovarian agonists (i.e., TNF alpha, IGF-I, interferon-gamma, and insulin) were without effect. Taken together, our findings establish the mammalian ovary as a site of cyclically determined Glut1 and Glut3 expression, and disclose the ability of IL-1 to induce the ovarian expression as well as translation of Glut1 and Glut3 (but not of Gluts 2, 4, or 5). Our observations also establish IL-1 as the first known regulator of Glut3, the most efficient Glut known to date. In so doing, IL-1, a putative component of the ovulatory process, may be acting to meet the increased metabolic demands imposed on the growing follicle and the ovulated cumulus-enclosed oocyte.
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
Authors: Dalya R. Soond, Elisa Bjørgo, Kristine Moltu, Verity Q. Dale, Daniel T. Patton, Knut Martin Torgersen, Fiona Galleway, Breda Twomey, Jonathan Clark, J. S. Hill Gaston, Kjetil Taskén, Peter Bunyard, Klaus Okkenhaug
Journal: Blood (2010)
Coexistent Nontoxic Lingual and Median-Cervical Ectopic Thyroid
Authors: Journel Alexandre
Journal: JAMA (1966)

THIS CASE is, to our knowledge, the second in the English literature in which simultaneous ectopia of the thyroid gland at the base of the tongue and in the subhyoid median cervical region was diagnosed preoperatively. Apparently, only three cases of combined glossal and subhyoid thyroid have been reported; of these, only one was diagnosed preoperatively.<sup>1</sup>Another case of lingual ectopia was diagnosed a few years after the surgical removal of a subhyoid thyroid, when laryngeal symptoms developed.<sup>1,2</sup>A third case of glossal ectopic thyroid, with a normally located thyroid gland, has been reported, and the patient died from severe hematemesis despite the fact that 22 units of blood had been given. Postmortem examination showed an ulcerated lingual thyroid.<sup>3</sup> It should be mentioned here that lingual thyroid and median-cervical thyroid have appeared separately in greater frequency. <h3>Report of a Case</h3> A 28-year-old Negro woman was admitted from
Role of caveolin-1 in the regulation of the vascular shear stress response
Authors: Philippe G. Frank, Michael P Lisanti
Journal: Journal of Clinical Investigation (2006)

In blood vessels, endothelia are submitted to constant shear effects and are, under normal conditions, capable of responding to any variation in hemodynamic forces. Caveolae — 50- to 100-nm plasma membrane invaginations present at the surface of terminally differentiated cells and particularly enriched in ECs — are composed of a high sphingolipid and cholesterol content and the protein caveolin-1 (Cav-1). Previous studies have suggested that caveolae and endothelial Cav-1 may regulate the vascular response to altered shear stress. In this issue of the JCI, Yu et al. have examined the role of Cav-1/caveolae in the regulation of flow-induced alterations (i.e., mechanotransduction) in vessels from wild-type mice, Cav-1–deficient mice, and Cav-1–deficient mice re-expressing Cav-1 only in ECs. Their data suggest that caveolae/Cav-1 may act as sensors of altered shear stress and that they also organize the signaling response in stimulated ECs (see the related article beginning on page 1284).
The role of hypersensitivity and the immune response in influencing susceptibility to metal toxicity.
Authors: G Kazantzis
Journal: Environmental Health Perspectives (1978)

The immune status of the individual is an additional variable which has to be taken into account in any consideration of factors which influence the metabolism and toxicity of metals. The commonly occurring phenomena are described resulting from increased cellular reactivity to platinum, mercury, gold, nickel, chromium, and beryllium, and an attempt has attempt has been made to classify these into the four types of immune response. The clinical effects can be very varied, giving rise to conjunctivitis, rhinitis, asthma, urticaria, contact dermatitis, proteinuria, nephrotic syndrome or blood dyscrasia. Of these effects, cutaneous hypersensitivity is the most common, affecting both industrial and general population groups. Metal compounds used in therapeutics and metals used in prostheses have also been responsible for hypersensitive reactions.
Alcohol's Effect on Trauma Outcomes
Authors: Carl A. Soderstrom
Journal: JAMA (1993)

"God protects small children and drunks." Based on anecdotal experiences, many trauma care clinicians agree with that thought by an unknown author. The child who rolls out of the upper bunk bed and is not hurt (even remains sleeping!) and the drunk driver who walks away from the severe wreck are thought to have been protected from injury because of the common factor of being relaxed and<i>loose</i>. In this issue, the study by Jurkovich and colleagues<sup>1</sup>of alcohol's effect on trauma outcomes seems to confirm the old adage. Using sound methods of investigation, they conclude that, for injuries of similar severity, acute alcoholic intoxication is not associated with increased mortality at the scene of injury, during the acute phase of hospital care, or more than 24 hours after admission, nor is it associated with an increase in morbidity as measured by in-hospital complication rates. See also p 51.
Anti-e and vertical transmission of hepatitis B surface antigen.
Authors: A K Chaudhuri, E A Follett, C J Burrell
Journal: BMJ (1977)

ordinary medical use.The fourth term for acidity is the concentration of free H ions in nmol/l derived from pH in a stricter manner than indicated above.Readers seeking more information about this complex matter are referred to Professor Siggaard-Andersen's contributions cited below.
'What Do You Care What Other People Think?': Further Adventures of a Curious Character
Authors: Alvin M. Cotlar
Journal: JAMA (1989)

The landing on March 18, 1989, of the orbiter<i>Discovery</i>and its crew marked another successful mission for the space program, back on line after the two-year break that followed the<i>Challenger</i>disaster of January 1986. The safety policies accompanying this most recent flight of<i>Discovery</i>(STS-29) were exemplary and reflect progress made since the<i>Challenger</i>and its aftermath.<i>Challenger: The Final Voyage</i>documented the tragedy and presented the findings and recommendations of the Rogers Commission (Challenger.<i>JAMA</i>. 1988;260:3070-3071). Richard P. Feynman, physicist and Nobel Prize winner, was asked to serve on that commission to help determine "what went wrong with the shuttle!" The second half of his book "<i>What Do You Care What Other People Think?</i>" is a delightful and amusing description of his service on the commission. The humor is so tasteful that the book maintains decorum in treating the shuttle explosion and loss of the astronauts and the
Effect of 8 weeks resistance training on plasma visfatin in middle aged men
Authors: Amin Mohammadi Domieh, Ali Khajehlandi
Journal: British Journal of Sports Medicine (2010)

Visfatin, a novel adipokine, is increased in obesity. It is not well known whether resistance training induced change in adipose tissue and blood lipids decrease plasma visfatin; thus, the purpose of this study was to examine the effect of 8 weeks' resistance training on plasma visfatin in middle-aged men. Nineteen healthy middle-aged men (aged 39.2 ± 4.6 years; height 173.8 ± 6.5 cm; BMI 24.8 ± 2.8 kg/m 2 ; mean ± SD) participated as subjects in this study. The subjects were randomly assigned to training group (n=9) or control group (n=10). Resistance training was performed for 3 days a week at an intensity corresponding to 65–80% of one-repetition maximum, 8–12 repetitions, 2–4 sets for 8 weeks. The results showed that body fat percent, WHR and plasma visfatin were decreased (p&lt;0.05) in the training group. Maximum oxygen consumption, on the other hand, increased significantly (p&lt;0.05) in the training group compared with the control group. Plasma visfatin levels at baseline were positively correlated (p&lt;0.05) with body fat percent and triglyceride concentration. In conclusion, it was seen that 8 weeks resistance training induced change in adipose tissue decreased plasma visfatin in middle-aged men.
Some Observations on the Aetiology of Breast Abscess in the Puerperium
Authors: D. H. K. Soltau, G. W. Hatcher
Journal: BMJ (1960)

BPX,B 1603 of arteritis of the peripheral nerves in two cases.A diffuse arteritis may be the cause of the neuropathy.The onset of peripheral neuropathy is of poor prognostic import in rheumatoid disease.I thank Dr. W. S. Tegner and Dr
THE COSMETIC AND VISUAL RESULTS IN SQUINT.
Authors: J. MORRISON RAY
Journal: JAMA (1901)

Since Donders first promulgated the statement that strabismus convergens always depends upon hypermetropia, to the present time, the study of the etiological factor or factors concerned, has been one of ever-increasing interest; yet much still remains unknown and unsettled in our knowledge of this complex condition. A step was taken forward when it was proven beyond question that there must be a something besides hypermetropia to determine a squint. Schweigger, Stilling, Hansen-Grut, Wahlfors and others have attacked the subject, but no one theory explains all the features sometimes encountered. The early age at which squint usually shows itself adds much to the difficulties of our gaining knowledge of the pre-existing conditions. The best way to approach the subject is by a careful study of cases. In doing this we often encounter phenomena that can not be explained by any of the ideas yet advanced. Leaving to others a discussion of
Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex
Authors: S. Mehdi Belgnaoui, Suzanne Paz, Sara Samuel, Marie-Line Goulet, Qiang Sun, Marjolein Kikkert, Kazuhiro Iwai, Ivan Dikic, John Hiscott, Rongtuan Lin
Journal: Cell Host & Microbe (2012)
Primary prophylaxis against gastric variceal bleeding: Is there a sticky solution at last?
Authors: Dhiraj Tripathi
Journal: Hepatology (2011)

In this randomized single center trial, 89 cirrhotic patients with GOV2 (eradicated esophageal varices) or IGV1 (both at least 10 mm size) not previously bled were selected for randomization over a 3 year period. Patients were randomized to: (1) Cyanoacrylate (n=30); (2) Propranolol (n=29); or (3) No treatment. There was complete obturation of GV in all patients after a mean of 1.6 ± 0.4 sessions. Propranolol was commenced at 20mg BD and titrated to aim for a heart rate of 55/min (mean dose 140 mg). There was no discontinuation of propranolol due to side effects. Hepatic venous pressure gradient (HVPG) measurements were performed at baseline and after 1 year in all groups and within 24h of bleeding. Most patients had alcoholic or cryptogenic cirrhosis and GOV2 (85%) of 20mm median size. The median follow up time was 26 (3-34) months. There was significantly lower gastric variceal bleeding with cyanoacrylate in (10% versus 38% and 53% for propranolol and no treatment respectively). There was no difference in bleeding between propranolol and no treatment. There was a significant reduction in HVPG in the propranolol group (35% had HVPG response) and an increase in the other groups. HVPG at baseline and HVPG response did not predict bleeding. There was a significant difference in overall and bleeding related mortality in favor of the cyanoacrylate group compared with no treatment (7 versus 26%). No difference in mortality was seen between propranolol and the other groups.
First test, then judge future-oriented behaviour in animals
Authors: Elisabeth H. M. Sterck, Valérie Dufour
Journal: Behavioral and Brain Sciences (2007)

Abstract Suddendorf &amp; Corballis (S&amp;C) argue that animals are not capable of mental time travel (MTT) or its components. However, new results on chimpanzees suggest that they plan for the future and possess some MTT components. Moreover, future-oriented behaviour and episodic-like memory in other animals suggest that not all animals are limited to the present. Animals' capacities should not be dismissed without testing them.
LAYER-SPECIFIC ANALYSIS OF MYOCARDIAL DEFORMATION WITH 2D SPECKLE-TRACKING ECHOCARDIOGRAPHY FOR PREDICTION OF FUNCTIONAL RECOVERY IN ACUTE MYOCARDIAL INFARCTION
Authors: Ertunc Altiok, Michael Becker, Christian Zwicker, Sandra Hamada, Ralf Koos, Nikolaus Marx, Rainer Hoffmann
Journal: Journal of the American College of Cardiology (2012)
Acute myocardial infarction and diabetes mellitus
Authors: J. Leor, R. W Nesto, R. A Kloner
Journal: Cardiovascular Research (1993)

Journal Article Acute myocardial infarction and diabetes mellitus Get access Johathan Leor, Johathan Leor Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard W Nesto, Richard W Nesto Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert A Kloner Robert A Kloner Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 11, November 1993, Pages 1913–1915, https://doi.org/10.1093/cvr/27.11.1913 Published: 01 November 1993
Reduction of hyperacute rejection and protection of metabolism and function in hearts of human decay accelerating factor (hDAF)-expressing pigs☆
Authors: R SMOLENSKI, M FORNI, M MACCHERINI, M BACCI, E SLOMINSKA, H WANG, P FORNASARI, R GIOVANNONI, F SIMEONE, A ZANNONI
Journal: Cardiovascular Research (2006)

The use of pig hearts can solve the problem of shortage of donor hearts for transplantation. However, targeting rejection by single genetic modification was proven to be ineffective, highlighting the requirement for complex genetic modifications and more effective methods for transgenic animal production. We evaluated here whether hearts of hDAF transgenic pigs generated using our technique sperm-mediated gene transfer (SMGT) will be protected from structural damage, metabolic changes, and mechanical dysfunction during perfusion with human blood.Hearts from control (C, n = 6) or transgenic (T, n = 5) pigs were perfused ex vivo for 4 h with fresh human blood using the ex vivo working mode system allowing monitoring of the function, metabolism, and structure.Cardiac output (mean+/-SEM) was maintained in T constant throughout the experiment, at 3.58+/-0.36 and 3.83+/-0.14 l/min after 30 min and 4 h, respectively, while cardiac output decreased to 1.95+/-0.35 l/min in C after 30 min of perfusion (p < 0.01 vs. T). The maximum increase in coronary perfusion pressure was reduced in T to 154+/-16% as compared to C (237+/-10%, p < 0.001). Myocardial ATP after 4 h was 21.1+/-1.1 nmol/mg dry wt (similar to initial) in T, while it decreased in C to 17.2+/-1.4 (p < 0.05). Deposition of complement factors C3 and C5b9 was present in C but not in T after perfusion.We have shown that hearts from hDAF transgenic pigs produced by SMGT are protected during perfusion with human blood and are metabolically stable and maintain mechanical function above the threshold level for life support.