tbuckley/cabot-search huggingface dataset:
Eligibility for Statin Therapy According to New Cholesterol Guidelines and Prevalent Use of Medication to Lower Lipid Levels in an Older US Cohort
Authors: Michael D. Miedema, Faye L. Lopez, Michael J. Blaha, Salim S. Virani, Josef Coresh, Christie M. Ballantyne, Aaron R. Folsom
Journal: JAMA Internal Medicine (2014)
Poor nations turn to innovative healthcare financing to scale up access
Authors: J. Zarocostas
Journal: BMJ (2009)

Poor nations are turning to innovative finance mechanisms to get more value out of outlays in health care aimed at scaling up access, quality, and equity for the world’s poorest people.

Estimates from Oxfam International report that more than 100 million people are pushed into poverty each year, often because of high out of pocket payments for health services.

It is in the face of these pressing challenges that researchers have come up with health equity funds, a purchasing mechanism that uses both donor and government subsidies pooled at district level to purchase public health services for the poor, heard delegates at the annual global forum for health research in Havana.

Peter Annear, senior research fellow at the Nossal Institute for …
Contact eczema in agricultural workers.
Authors: T A Dawson, K W Scott
Journal: BMJ (1972)

We report four patients with ``dropped head syndrome,99 a recently described nonprogressive myopathy characterized by severe neck extensor weakness.This relatively benign condition may be confused with more ominous neuromuscular disorders that also present with prominent neck weakness. We compared clinical and laboratory data from the patients with dropped head syndrome with findings from patients with head drop caused by other neuromuscular conditions. Patients with ``isolated neck extensor myopathy,99 a term we prefer to ``dropped head syndrome,99 could be readily identified with electrophysiologic, radiographic, and histologic studies. <b>NEUROLOGY 1996;46: </b> 917-921
Adalimumab therapy for moderate to severe psoriasis: A randomized, controlled phase III trial
Authors: Alan Menter, Stephen K. Tyring, Kenneth Gordon, Alexa B. Kimball, Craig L. Leonardi, Richard G. Langley, Bruce E. Strober, Martin Kaul, Yihua Gu, Martin Okun, Kim Papp
Journal: Journal of the American Academy of Dermatology (2007)
Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features
Authors: Pieter W. Kamphuisen, Joost Haan, Peter C.M. Rosekrans, Felix J.M. Van Der Meer
Journal: American Journal of Hematology (1998)

We report a 71-year-old man who developed deep-vein thrombosis after major surgery. Coumarin skin necrosis developed after starting oral anticoagulant therapy. An inhibitor to factor V (61 Bethesda units) with lupus-like features was found as well as a low protein C level. The occurrence of these very rare findings indicates that despite profound procoagulant inhibition (factor V inhibition and anticoagulant therapy), hypercoagulation can occur. Am. J. Hematol. 57:176–178, 1998. © 1998 Wiley-Liss, Inc.
Worry About Developing Melanoma in the Pigmented Lesion Clinic
Authors: Jennifer L. Hay
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Screening for Colorectal Cancer
Authors: Sidney J. Winawer
Journal: JAMA (1977)

<h3>To the Editor. —</h3> I was disturbed by the letter from Morton Goodman, MD, (237:2380, 1977) because of the methodology used for screening patients for colorectal cancer with Hemoccult slide testing and the conclusions drawn, which I believe to be invalid. Conclusions drawn by Dr Goodman were that the Hemoccult test was an insensitive method for detecting occult blood in the stools of patients in a mass screening setting and, further, that it was of no value in detecting early colorectal cancer in an asymptomatic adult population. The first conclusion regarding sensitivity cannot be addressed by Dr Goodman's study because he has provided no information on the number of patients who have documented blood in the stool by other methods, such as chromium-tagged red cells. Therefore, the test could actually have been extremely sensitive in detecting occult blood in the stools in his group of patients if no other patients
Occupational Benzene Exposure and Lymphoma Risks: Vlaanderen et al. Respond
Authors: Jelle Vlaanderen, Qing Lan, Nat Rothman, Hans Kromhout, Roel Vermeulen
Journal: Environmental Health Perspectives (2011)

In their recent meta-analysis, Vlaanderen et al. (2011) claimed to show evidence for associations between occupational benzene exposure and risks of multiple myeloma, acute lymphocytic leukemia, and chronic lymphocytic leukemia.However, one of the larger available studies, including 5,514 benzene-exposed UK workers (Sorahan et al. 2005), was excluded from this meta-analysis, apparently because the study had an elevated standardized mortality ratio (SMR) for secondary and unspecified cancers.On the basis of national mortality rates, we would have expected 7% of all cancer deaths in the UK study to have been in the unspecified cate gory (e.g., carcinomatosis, mesothelioma with site unspecified); however, 9% of deaths were unspecified.Given the size of the study (2,430 deaths from all causes), this difference was statistically significant (Sorahan et al. 2005).Is it reasonable to conclude that a study with 93% of cancer deaths with site of cancer specified is informative but one with only 91% specified is not?I do not believe that it is.Vlaanderen et al. (2011) are of course free to come to a different conclusion, but any conclusion they reach must be implemented in an even-handed way.Some obvious questions then arise: a) How elevated did the SMR for unspecified cancers have to be for a study to be excluded from their meta-analysis?b) Were all the other studies assessed against this criterion?c) How many studies did not provide enough information for this criterion to be assessed?d) Why was this number not supplied by Vlaanderen et al.
Very Late Antigen-4 in CD18-Independent Neutrophil Emigration during Acute Bacterial Pneumonia in Mice
Authors: Sadatomo Tasaka, Sarah E. Richer, Joseph P. Mizgerd, Claire M. Doerschuk
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

This study tested the hypothesis that very late antigen (VLA)-4 mediates CD18-independent neutrophil emigration into the airspaces induced by either Streptococcus pneumoniae, a stimulus that induces primarily CD18-independent neutrophil emigration, or Escherichia coli, toward which only 20–30% of the total number of neutrophils emigrate through CD18-independent pathways. In wild-type (WT) mice, VLA-4 expression was less on neutrophils that emigrated into the airspaces than on circulating neutrophils. Vascular cell adhesion molecule-1 (VCAM-1) mRNA, the major endothelial cell ligand for VLA-4, increased more in E. coli than in S. pneumoniae pneumonia. VCAM-1 protein expression was not detected in capillaries, the major site of neutrophil emigration. Neutrophil emigration during E. coli or S. pneumoniae pneumonia was similar in mice given antibodies against both CD18 and VLA-4 compared with mice given the anti-CD18 antibody and a control antibody. However, in hematopoietically reconstituted mice with both WT and CD18-deficient neutrophils in their blood, the migration of CD18-deficient neutrophils in response to S. pneumoniae was slightly but significantly less in animals pretreated with the anti–VLA-4 antibody than in those receiving a control antibody. These data suggest that VLA-4 plays a small role in CD18-independent neutrophil emigration, but the majority of CD18-independent neutrophil emigration induced by bacteria in the lungs occurs through VLA-4–independent mechanisms.
Jones Criteria (Modified) for Guidance in the Diagnosis of Rheumatic Fever
Authors: DAVID D. RUTSTEIN, WALTER BAUER, ALBERT DORFMAN, ROBERT E. GROSS, JOHN A. LICHTY, HELEN B. TAUSSIG, RUTH WHITTEMORE, KATHERINE HAGBERG, MARY E. PARKER
Journal: Circulation (1956)

published criteria for the diagnosis of rheumatic fever which have been gener- ally accepted in the United States and in many parts of the world.
Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia
Authors: Chiharu Sugimori, Tatsuya Chuhjo, Xingmin Feng, Hirohito Yamazaki, Akiyoshi Takami, Masanao Teramura, Hideaki Mizoguchi, Mitsuhiro Omine, Shinji Nakao
Journal: Blood (2005)
Conserving effect of thyroid hormone on myocardial ATP stores in vitro
Authors: J. COHEN, A. A. WHITBECK, F. E. KARCH
Journal: Cardiovascular Research (1973)

L-thyroxine supported falling tissue ATP concentration above control levels in isolated, hypoxic rat atria. The hormone also decreased tissue lactate production, and — probably secondarily — increased incorporation of L-leucine into atrial protein. These metabolic effects seem independent of hormone effects on contractility and suggest that thyroxine may enhance delivery of useful energy to the tissue.
Unrecognized Human Immunodeficiency Virus Infection in Emergency Department Patients
Authors: Gabor D. Kelen, Stuart Fritz, Bahjat Qaqish, Ronald Brookmeyer, James L. Baker, Richard L. Kline, Robin M. Cuddy, Tracey K. Goessel, Douglas Floccare, Kathleen A. Williams, Keith T. Sivertson, Scott Altman, Thomas C. Quinn
Journal: New England Journal of Medicine (1988)

To determine the extent of unrecognized human immunodeficiency virus (HIV) infection, we examined blood samples drawn from patients presenting to an inner-city emergency department. We found 119 of 2302 consecutive adult patients (5.2 percent) to be seropositive for HIV. Although 27 patients presented with known symptomatic HIV infection, 92 of the remaining 2275 patients (4.0 percent) had unrecognized HIV infection. The highest seroprevalence rate (11.4 percent) was found among black men 30 to 34 years of age. Blacks, other nonwhites, and patients under the age of 45 had high rates of unrecognized infection. The clinical team established risk-factor status in only 29.0 percent of the patients. Of the 276 patients with identified risk factors, 13.0 percent were seropositive, whereas 3.1 percent of the 1616 patients with unknown risk-factor status were seropositive. None of the 102 patients who reported no risk factors were seropositive. Although penetrating trauma (seroprevalence, 13.6 percent) was the only clinical presentation associated with an increased seroprevalence rate independent of other known predictors of infection (P = 0.02), seropositive patients were found in all categories of clinical condition. These data, although based on observations in one emergency department setting, support the concept of universal blood and body-fluid precautions by all health care workers whether or not HIV infection is known. (N Engl J Med 1988; 318:1645–50.)
Moxalactam in Pleural Fluids
Authors: Henry M. Faris, David W. Potts
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Moxalactam in Pleural FluidsHENRY M. FARIS JR., M.D., DAVID W. POTTS, M.D.HENRY M. FARIS JR., M.D.Search for more papers by this author, DAVID W. POTTS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-144_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Pharmacologic data on moxalactam levels in pleural fluids are limited. We had an opportunity to evaluate levels in noninfected hospitalized patients.Six seriously ill patients (two with congestive heart failure; three with metastatic carcinoma; and one with idiopathic pleural effusion), ages 59 to 84 years, were given moxalactam, 1 g over 20 minutes by intravenous infusion. Pleural fluids were aspirated at 1 or 2 hours after infusion (or both) by thoracentesis in four patients and by chest-tube drainage in two patients.Nine samples each of pleural fluid and serum were collected at 1 hour. Pleural levels of...References1. BERGOGNE-BEREZINMORELBENARDBERTHELOTKAFE ECYGH. Pharmacokinetic study of beta-lactam antibiotics in bronchial secretions. Scand J Infect Dis. 1978;14(suppl):267-72. Google Scholar2. AlexanderSchoellHicklinKasikColeman MJGJD. Bronchial secretion concentrations of tobramycin. Am Rev Respir Dis. 1982;125:208-9. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1984Volume 101, Issue 1Page: 144-144KeywordsHeart failurePleural effusion Issue Published: 1 July 1984 PDF DownloadLoading ...
Preoperative Prediction of Postoperative Delirium
Authors: Marc A. Rozner
Journal: JAMA (1994)

<h3>To the Editor.</h3> —I fail to understand the wisdom of excluding input from an anesthesiologist in the design or implementation of the recently published study by Marcantonio et al.<sup>1</sup>The authors' attempt to link postoperative delirium to preoperative risk factors without controlling for time of surgery start, anesthetic technique, postoperative analgesic technique, need for continued postoperative ventilation and sedation, and need for postoperative intensive care flies in the face of modern science. For example, many anesthesiologists currently use high-dose opiate techniques for major abdominal vascular repair (ie, aortic aneurysm surgery), and many of these patients spend their first 24 postoperative hours in an intensive care unit. That these patients are at higher risk for postoperative delirium or confusion than a healthy 40-year-old woman undergoing tubal ligation comes as no surprise to any anesthesiologist. The authors' comment that intervention strategies for reducing the probability of postoperative delirium "include close monitoring and
A NOVEL RISK SCORE FOR PERCUTANEOUS CORONARY INTERVENTION OUTCOME ASSESSMENT: WEIGHING THE IMPORTANCE OF COMPLICATIONS AFTER PROCEDURE
Authors: Gabriel Maluenda, Cedric Delhaye, Michael A. Gaglia, Manuel A. Gonzalez, Itsik Ben-Dor, Nicholas N. Hanna, Kohei Wakabayashi, Rebecca Torguson, Zehnyi Xue, William O. Suddath, Lowell F. Satler, Kenneth M. Kent, Joseph M. Lindsay, Augusto D. Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2010)
Employment Status of House Staff-Reply
Authors: Ralph M. Stanifer
Journal: JAMA (1980)

In Reply.—  I take issue with Dr Challoner's assertion that house staff members have been classified as students all along. House staff members have been classified as employees in several individual states, including Michigan, New York, California, Illinois, and others, for many years. In addition, the Internal Revenue Service, the Social Security Administration, and state and local governmental agencies treat residents' salaries as earned income. As National Labor Relations Board member John H. Fanning has pointed out, part of section 2(12) of the National Relations Act was specifically designed to cover house staff.  As educators and practitioners, we should be supportive of our colleagues in specialty training. The role of a house officer is entirely different in scope and responsibility than that of a medical student. House staff members earn a moderate salary in exchange for educational opportunities. However, to claim that this salary is not earned income is to
A regular meal and insulin infusion regimen: its use in the treatment of acute-onset ketotic diabetes and in stabilization of poorly controlled established diabetic subjects
Authors: T. M. Davis, R. R. Holman, P. M. Eaton, R. C. Turner
Journal: Diabetes Care (1982)

A simple regimen, consisting of a constant intravenous insulin infusion at either a basal, nocturnal rate or at a daytime rate matched by seven small, isocaloric meals taken every 2 h, has been applied to two clinical situations requiring optimal blood glucose control. In eight poorly controlled established diabetic subjects, quantitative estimates of daily insulin requirements were possible, with consequent improved control upon reinstitution of twice-daily subcutaneous insulin. In five acute-onset, ketotic diabetic subjects first treated by intravenous saline and low-dose intramuscular insulin, the regimen was used to achieve and maintain basal and postprandial normoglycemia. Ketonuria was abolished quickly in these patients, and falling insulin requirements and large doses of insulin were handled easily. In both clinical situations, subsequent subcutaneous insulin doses required little adjustment. The regimen is cheap, convenient to use, and widely applicable.
Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human hearts
Authors: Nezam Haider, Eloisa Arbustini, Sudhir Gupta, Han Liu, Navneet Narula, Roger Hajjar, Narain Moorjani, Stephen Westaby, Marc J Semigran, G William Dec, Y Chandrashekhar, Jagat Narula
Journal: Nature Reviews Cardiology (2009)
TCT- 94 Long-term clinical outcomes of patients with coronary artery aneurysm after drug-eluting stent implantation
Authors: Hyung Joon Joo, Cheol Woong Yu, Rak Kyong Choi, Jin Sik Park, Hyun Jong Lee, Je Sang Kim, Young Jin Choi, Jae Hyoung Park, Soon Jun Hong, Do-Sun Lim
Journal: Journal of the American College of Cardiology (2014)
Ovarian Overstimulation, Massive Ascites, and Singleton Pregnancy After Clomiphene
Authors: Antonio Scommegna
Journal: JAMA (1969)

Bilateral ovarian enlargement with massive ascites and pregnancy occurred in a patient after two courses of clomiphene citrate (Clomid) therapy. It is likely that the patient received the second course of clomiphene during early stages of pregnancy. Early pregnancy must be ruled out prior to the administration of this type of therapy.
Fibrinolytics vs primary angioplasty in acute myocardial infarction (FAP): A randomized trial in a community hospital in Argentina
Authors: Liliana Grinfeld, Daniel Berrocal, Jorge Belardi, Alejandro Spinetta, Carlos Rojas Matas, Pablo Oberti, Heman Doval, Oscar Bazzino, Arturo Cagide
Journal: Journal of the American College of Cardiology (1996)
Endoscopic Removal of a Pedunculated Bronchial Lipoma by means of the Hot Snare
Authors: L. C. Müller, R. Pointner, K. W. Schmid, G. M. Salzer
Journal: Endoscopy (1989)

The complete endoscopic removal by means of the hot snare of a pedunculated bronchial lipoma with a carcinoma in situ in its covering bronchial epithelium is reported. To our knowledge, the endoscopic removal of peripheral polypoid bronchial lesions has not been reported to date. The advantage of this technique lies in its ability to permit an exact histologic examination of the lesion, in contrast to laser vaporisation.
Brain evolution: Part I
Authors: Elizabeth Adkins-Regan
Journal: Behavioral and Brain Sciences (2006)

Striedter's accessible concept-based book is strong on the macroevolution of brains and the developmental principles that underlie how brains evolve on that scale. In the absence of greater attention to microevolution, natural selection, and sexual selection, however, it is incomplete and not fully modern on the evolution side. Greater biological integration is needed.
Can we identify and treat "schizophrenia light" to prevent true psychotic illness?
Authors: J. van Os, R. M. Murray
Journal: BMJ (2013)

Better to focus on treating psychosis in non-psychotic disorders

In a linked meta-analysis, Stafford and colleagues (doi:10.1136/bmj.f185) provide evidence that cognitive behavioural therapy (CBT) may show some modest benefits in preventing transition to psychosis at 12 months’ follow-up in patients at high risk.1 In doing so, they summarise a huge amount of work on interventions to prevent psychosis. However, this approach assumes that a discrete state of high risk for psychosis exists, an assumption that has increasingly been challenged.

Traditionally, phenomena such as delusions and hallucinations (hereafter, psychosis) were thought to be diagnostic indicators of psychotic disorders such as schizophrenia. However, psychotic symptoms are more common than was previously realised. They are present—at various degrees of severity—in about 5% of the general population who are not seeking help; in about 25% of people with (non-psychotic) common mental disorders, such as anxiety and depression; and in around 80% of patients with psychotic disorders.2 

Low grade psychotic phenomena in those not seeking help are associated with an increased relative risk—albeit low absolute risk—of later psychotic disorder, and, more surprisingly, also of non-psychotic mental disorder.3 Furthermore, low grade psychotic symptoms in people with common mental disorders predict a poorer prognosis, similar …
GUSTATORY HYPERRTBROSIS. A Complication of Thyroidectomy.
Authors: W. J. Cunliffe, C. E. JOHNSON
Journal: British Journal of Dermatology (1967)

Journal Article GUSTATORY HYPERRTBROSIS. A Complication of Thyroidectomy. Get access W. J. Cunliffe, B.Sc, M.B., M.R.C.P., W. J. Cunliffe, B.Sc, M.B., M.R.C.P. University Department of Dermatology, Royal Victoria Infirmary, Newcastle Upon Tyne Search for other works by this author on: Oxford Academic Google Scholar C. E. JOHNSON, B.Sc. C. E. JOHNSON, B.Sc. University Department of Dermatology, Royal Victoria Infirmary, Newcastle Upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 10, 1 October 1967, Pages 519–526, https://doi.org/10.1111/j.1365-2133.1967.tb11406.x Published: 01 October 1967
Theatre: I'mperfect
Authors: H. Lucas
Journal: BMJ (2002)

A show by comedian Francesca Martinez Pleasance Theatre, Edinburgh, until 26 August www.pleasance.co.uk/edin/prog/folders/francesca/index.html Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> As with any stand-up comedian worth his or her salt, Francesca Martinez shifts so rapidly between the sublime, the ridiculous, and the bizarre that her audience has to concentrate ferociously on keeping up with her stories, one liners, and visual gags. She muses on the aims of advertising, touches on the rather tricky morality of the United Kingdom supplying arms to both India and Pakistan, and then on how each one of us has a special face for the mirror. So far, so good. Why does she merit a review out of all the sparky, clever, anarchic, comics at Edinburgh this year? Francesca Martinez: makes real the misunderstanding that many people have of disability Her opening, slightly slurred line, as she is escorted on to the stage with her spastic gait, is “There's a word for people like me.” (“Oh good,” you think, “She's going to make it … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
307 HYDRODYNAMICS-BASED TRANSFECTION OF PANCREATIC DUODENAL HOMEOBOX 1 DNA IMPROVES HYPERGLYCEMIA AND IS ASSOCIATED WITH LIMITED COMPLICATIONS IN DIABETIC MICE
Authors: M.-L. Chang, T.-H. Chen, C.-T. Yeh, C.-T. Chiu, D.-Y. Lin
Journal: Journal of Hepatology (2009)