Fluoride Treatment of Osteoporosis: A New Look at an Old Drug
Authors: DANIEL D. BIKLE
Journal: Annals of Internal Medicine (1983)

Editorials1 June 1983Fluoride Treatment of Osteoporosis: A New Look at an Old DrugDANIEL D. BIKLE, M.D., PH.D.DANIEL D. BIKLE, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1013 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe morbidity and mortality from fractures attributable to eroded bone mass is a billion dollar problem affecting hundreds of thousands of men and women each year in the United States alone (1). As our citizens live longer, we can expect this problem to increase.Fluoride has attracted attention as a therapeutic agent for osteoporosis because it is one of the most effective stimulators of new bone growth. The mechanisms by which fluoride induces new bone growth are not known. Fluoride is rapidly and extensively accumulated into bone mineral and teeth. X-ray crystallographic data show a stabilization by fluoride of the...References1. OWEN R, MELTON L, GALLAGHER J, and RIGGS B. The national cost of acute care of hip fractures associated with osteoporosis. Clin Orthop. 1980;150:172-6. CrossrefGoogle Scholar2. MEEMA H and MEEMA S. Prevention of postmenopausal osteoporosis by hormone treatment of the menopause. Can Med Assoc J. 1968;99:248-51. MedlineGoogle Scholar3. RIGGS B, JOWSEY J, KELLY P, and HOFFMAN D. Treatment for postmenopausal and senile osteoporosis. Med Clin North Am. 1972;56:989-97. CrossrefMedlineGoogle Scholar4. GALLAGHER J, AARON J, HORSMAN A, MARSHALL D, WILKINSON R, and NORDIN B. The crush fracture syndrome in postmenopausal women. Clin Endocrinol Metab. 1973;2:293-315. CrossrefMedlineGoogle Scholar5. LINDSEY R, HART D, AITKEN J, MACDONALD E, ANDERSON J, and CLARKE A. Long-term prevention of postmenopausal osteoporosis by oestrogen. Lancet. 1976;1:1038-40. CrossrefMedlineGoogle Scholar6. CHRISTIANSEN C, CHRISTENSEN M, MCNAIR P, HAGEN C, STOCKLUND K, and TRANSBOL J. Prevention of early postmenopausal bone loss: controlled 2-year study in 315 females. Eur J Clin Invest. 1980;10:273-9. CrossrefMedlineGoogle Scholar7. SHAPIRO J, MOORE W, JORGENSEN H, REID J, EPPS C, and WHEDON D. Osteoporosis: evaluation of diagnosis and therapy. Arch Intern Med. 1975;135:563-7. CrossrefMedlineGoogle Scholar8. RIGGS B, WAHNER H, DUNN W, MAZESS R, OFFORD K, and MELTON L. Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. J Clin Invest. 1981;67:328-35. CrossrefMedlineGoogle Scholar9. GALLAGHER J, RIGGS B, EISMAN J, HAMSTRA A, ARNAUD S, and DELUCA H. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest. 1979;64:729-36. CrossrefMedlineGoogle Scholar10. MEUNIER P, COURPRON P, GIROUX J, EDOUARD C, BERNARD J, and VIGNON G. Bone histomorphometry as applied to research on osteoporosis and to the diagnosis of "hyperosteoidosis states. " Calcif Tiss Res. 1976;21:354-60. CrossrefMedlineGoogle Scholar11. MINAIRE P, MEUNIER P, EDOUARD C, BERNARD J, COURPRON P, and BARRET J. Quantitative histological data on disuse osteoporosis: comparison with biological data. Calcif Tiss Res. 1974;17:57-73. CrossrefMedlineGoogle Scholar12. DONALDSON C, HULLEY S, VOGEL J, HATTNER R, BAYERS J, and MACMILLAN D. Effect of prolonged bed rest on bone mineral. Metabolism. 1970;19:1071-84. CrossrefMedlineGoogle Scholar13. RAMBOUT P and JOHNSEN R. Prolonged weightlessness and calcium loss in man. Acta Astron. 1979;6:1113-22. CrossrefMedlineGoogle Scholar14. GENANT H, HECK L, LANZI L, ROSSMANN K, VANDER HORST J, and PALOYAN E. Primary hyperparathyroidism: a comprehensive study of clinical, biochemical, and radiographic manifestations. Radiology. 1973;109:513-24. CrossrefMedlineGoogle Scholar15. BAYLEY T, HARRISON J, MCNEILL K, and MERNAGH J. Effect of thyrotoxicosis and its treatment on bone mineral and muscle mass. J Clin Endocrinol Metab. 1980;50:916-22. CrossrefMedlineGoogle Scholar16. GALLAGHER J, AARON J, HORSMAN A, WILKINSON R, and NORDIN B. Corticosteroid osteoporosis. Clin Endo Metab. 1973;2:355-68. CrossrefGoogle Scholar17. HAHN T. Corticosteroid-induced osteopenia. Arch Intern Med. 1978;138:882-5. CrossrefMedlineGoogle Scholar18. FACCINI J. Fluoride and bone. Calcif Tiss Res. 1969;3:1-16. CrossrefMedlineGoogle Scholar19. COHEN P, NICHOLS G, and BANKS H. Fluoride treatment of bone rarefaction in multiple myeloma and osteoporosis. Clin Orthop. 1969;64:221-49. MedlineGoogle Scholar20. LEONE N, STEVENSON C, BESSE B, HAWES L, and DAWBER T. The effect of the absorption of fluoride: II. A radiological investigation of 546 human residents of an area in which the drinking water contained only a minute trace of fluoride. Arch Intern Health. 1960;21:326-32. MedlineGoogle Scholar21. BERNSTEIN D, SADOWSKY N, HEGSTED D, GURI C, and STARE F. Prevalence of osteoporosis in high- and low-fluoride areas in North Dakota. JAMA. 1966;198:499-504. CrossrefMedlineGoogle Scholar22. KUO H and WUTHIER R. An investigation of fluoride protection against dietary induced osteoporosis in the rat. Clin Orthop. 1975;110:324-31. CrossrefGoogle Scholar23. GRIFFITHS H, HUNT R, ZIMMERMAN R, FINBERG H, and CUTTINO J. The role of calcium and fluoride in osteoporosis in rhesus monkeys. Invest Radiol. 1975;10:263-8. CrossrefMedlineGoogle Scholar24. EPKER B. Studies on bone turnover and balance in the rabbit: III. Effects of hydrocortisone plus fluoride. Clin Orthop. 1970;72:336-43. MedlineGoogle Scholar25. MILICIC M and JOWSEY J. Effect of fluoride on disuse osteoporosis in the cat. J Bone Joint Surg. 1968;50A:701-8. CrossrefGoogle Scholar26. ROSEN D, GEDALIA I, ANAISE J, SIMKIN A, and ARCAN M. The effect of fluoride alone or fluoride followed by calcium and vitamin D on disuse osteoporosis of the rat tail vertebrae. Calcif Tiss Res. 1975;19:9-15. CrossrefMedlineGoogle Scholar27. MESSER H, ARMSTRONG W, and SINGER L. Fluoride, parathyroid hormone and calcitonin: Effects on metabolic processes involved in bone resorption. Calcif Tiss Res. 1973;13:227-33. CrossrefMedlineGoogle Scholar28. BERNSTEIN D and COHEN P. Use of sodium fluoride in the treatment of osteoporosis. J Clin Endocrinol Metab. 1967;27:197-210. CrossrefMedlineGoogle Scholar29. COHN S, DOMBROWSKI C, HAUSER W, and ATKINS H. Effects of fluoride on calcium metabolism in osteoporosis. Am J Clin Nutr. 1971;24:20-8. CrossrefMedlineGoogle Scholar30. RICH C and IVANOVICH P. Response to sodium fluoride in severe primary osteoporosis. Ann Intern Med. 1965;63:1069-74. LinkGoogle Scholar31. FRANKE J, REMPEL H, and FRANKE M. Three years' experience with sodium-fluoride therapy of osteoporosis. Acta Orthop Scand. 1974;45:1-20. CrossrefMedlineGoogle Scholar32. GROVE O and HALVER B. Relief of osteoporotic backache with fluoride, calcium and calciferol: a randomized clinical trial. Acta Med Scand. 1981;209:469-71. CrossrefMedlineGoogle Scholar33. HANSSON T and ROOS B. Effect of combined therapy with sodium fluoride, calcium and vitamin D on the lumbar spine in osteoporosis. Am J Roent. 1976;126:1294-6. CrossrefMedlineGoogle Scholar34. HARRISON J, MCNEILL K, and STURTRIDGE W. Three-year changes in bone mineral mass of postmenopausal osteoporotic patients based on neutron activation analysis of the central third of the skeleton. J Clin Endocrinol Metab. 1981;52:751-8. CrossrefMedlineGoogle Scholar35. MANZKE E, RAWLEY R, VOSE G, ROGINSKY M, RADER J, and BAYLINK D. Effect of fluoride therapy on nondialyzable urinary hydroxyproline, serum alkaline phosphatase, parathyroid hormone, and 25-hydroxyvitamin D. Metabolism. 1977;26:1005-10. CrossrefMedlineGoogle Scholar36. VOSE G, KEELE D, MILNER A, RAWLEY R, ROACH T, and SPRINKLE E. Effect of sodium fluoride, inorganic phosphate and oxymetholone therapies in osteoporosis: a six year progress report. J Gerontol. 1978;33:204-12. CrossrefMedlineGoogle Scholar37. JOWSEY J, RIGGS B, KELLY P, and HOFFMAN D. Effect of combined therapy with sodium fluoride, vitamin D and calcium in osteoporosis. Am J Med. 1972;53:43-9. CrossrefMedlineGoogle Scholar38. PARSONS V, MITCHELL C, REEVE J, and HESP R. The use of sodium fluoride, vitamin D and calcium supplements in the treatment of patients with axial osteoporosis. Calcif Tiss Res. 1977;22:236-40. CrossrefMedlineGoogle Scholar39. BRIANCON D and MEUNIER P. Treatment of osteoporosis with fluoride, calcium, and vitamin D. Orthop Clin North Am. 1981;12:629-48. CrossrefMedlineGoogle Scholar40. BAYLINK D and BERNSTEIN D. The effects of fluoride therapy on metabolic bone disease. Clin Orthop. 1967;55:51-85. MedlineGoogle Scholar41. RIGGS B, SEEMAN E, HODGSON S, TAVES D, and O'FALLON W. Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis. N Engl J Med. 1982;306:446-50. CrossrefMedlineGoogle Scholar42. RIGGS B, HODGSON S, HOFFMAN D, KELLY P, JOHNSON K, and TAVES D. Treatment of primary osteoporosis with fluoride and calcium: clinical tolerance and fracture occurrence. JAMA. 1980;243:446-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL D. BIKLE, M.D., PH.D.Affiliations: University of California San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParenteral calcitonin for metabolic bone disease associated with primary biliary cirrhosisLack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patientsDiagnóstico y manejo de mujeres con osteoporosis post-menopáusicasEffect of chronic carbonic anhydrase inhibitor therapy on bone mineral density in white womenSide-effects of fluoride therapyAssessment by reflection ultrasound method of the effect of intermittent slow-release sodium fluoride-calcium citrate therapy on material strength of boneIssues of Aging in Preventive Medicine and the Example of OsteoporosisSalmon Calcitonin in the Treatment of Postmenopausal OsteoporosisVAHAB FATOURECHI, M.D., HUNTER HEATH III, M.D.Postmenopausal osteoporosis—Intervention and prophylaxis. 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