tbuckley/cabot-search huggingface dataset:
Absence of circulating immune complexes in acne vulgaris
Authors: Craig G. Burkhart, P.F. Lehmann
Journal: British Journal of Dermatology (1982)

Journal Article Absence of circulating immune complexes in acne vulgaris Get access Craig G. Burkhart, Craig G. Burkhart Division of Dermatology, Department of Microbiology, Medical College of Ohio, Toledo, Ohio 43699, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar P.F. Lehmann P.F. Lehmann Division of Dermatology, Department of Microbiology, Medical College of Ohio, Toledo, Ohio 43699, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 1, 1 January 1982, Pages 120–121, https://doi.org/10.1111/j.1365-2133.1982.tb00915.x Published: 01 January 1982
1181 STUDY OF I/D POLYMORPHISM OF ANGIOTENSIN CONVERTING ENZYME (ACE) IN CHRONIC HEPATITIS C: INFECTION, PROGRESSION AND RESPONSE TO THERAPY
Authors: F. Serejo, J. Ferreira, C. Baldaia, G. Boleto, R. Correia, M. Bicho, C. Marinho
Journal: Journal of Hepatology (2011)
Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin(NPI-2358) in Patients with Solid Tumors or Lymphomas
Authors: Monica M. Mita, Matthew A. Spear, Lorrin K. Yee, Alain C. Mita, Elisabeth I. Heath, Kyriakos P. Papadopoulos, Kristine C. Federico, Steven D. Reich, Ofelia Romero, Lisa Malburg, MaryJo Pilat, G. Kenneth Lloyd, Saskia T.C. Neuteboom, Gillian Cropp, Edward Ashton, Patricia M. LoRusso
Journal: Clinical Cancer Research (2010)

Abstract Purpose: Plinabulin (NPI-2358) is a vascular disrupting agent that elicits tumor vascular endothelial architectural destabilization leading to selective collapse of established tumor vasculature. Preclinical data indicated plinabulin has favorable safety and antitumor activity profiles, leading to initiation of this clinical trial to determine the recommended phase 2 dose (RP2D) and assess the safety, pharmacokinetics, and biologic activity of plinabulin in patients with advanced malignancies. Experimental Design: Patients received a weekly infusion of plinabulin for 3 of every 4 weeks. A dynamic accelerated dose titration method was used to escalate the dose from 2 mg/m2 to the RP2D, followed by enrollment of an RP2D cohort. Safety, pharmacokinetic, and cardiovascular assessments were conducted, and Dynamic contrast-enhanced MRI (DCE-MRI) scans were performed to estimate changes in tumor blood flow. Results: Thirty-eight patients were enrolled. A dose of 30 mg/m2 was selected as the RP2D based on the adverse events of nausea, vomiting, fatigue, fever, tumor pain, and transient blood pressure elevations, with DCE-MRI indicating decreases in tumor blood flow (Ktrans) from 13.5 mg/m2 (defining a biologically effective dose) with a 16% to 82% decrease in patients evaluated at 30 mg/m2. Half-life was 6.06 ± 3.03 hours, clearance was 30.50 ± 22.88 L/h, and distributive volume was 211 ± 67.9 L. Conclusions: At the RP2D of 30 mg/m2, plinabulin showed a favorable safety profile, while eliciting biological effects as evidenced by decreases in tumor blood flow, tumor pain, and other mechanistically relevant adverse events. On the basis of these results additional clinical trials were initiated with plinabulin in combination with standard chemotherapy agents. Clin Cancer Res; 16(23); 5892–99. ©2010 AACR.
Study of coronary risk factors related to physical activity in 15 171 men.
Authors: N Hickey, R Mulcahy, G J Bourke, I Graham, K Wilson-Davis
Journal: BMJ (1975)

Physical activity, both at work and during leisure, was assessed in 15 171 men aged 25-74 years. Heavy leisure activity was associated with lower mean serum cholesterol levels and blood pressure. In men under 60 years the same negative association was also noted between leisure activity and relative weight and cigarette smoking. Different degrees of physical activity at work were not associated with any differences in these risk factors, nor did the level of exercise at work seem to influence the negative association between leisure activity and risk factors. Heavy leisure activity in young and middle-aged men is associated with lower levels of certain coronary risk factors and, therefore, a lower risk of coronary heart disease. The often-reported reduction in coronary morbidity and mortality with physical exercise may not be the direct effect of the exercise itself.
Phase I Study of Everolimus in Pediatric Patients With Refractory Solid Tumors
Authors: Maryam Fouladi, Fred Laningham, Jianrong Wu, Melinda A. O'Shaughnessy, Kristen Molina, Alberto Broniscer, Sheri L. Spunt, Inga Luckett, Clinton F. Stewart, Peter J. Houghton, Richard J. Gilbertson, Wayne L. Furman
Journal: Journal of Clinical Oncology (2007)

Purpose To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetic and pharmacodynamic properties of the mammalian target of rapamycin (mTOR) inhibitor, everolimus, in children with refractory or recurrent solid tumors. Patients and Methods Everolimus was administered orally at a daily dose of 2.1, 3, 5, or 6.5 mg/m 2 in cohorts of three to six patients per dosage level. Pharmacokinetic and pharmacodynamic studies were performed during the first course. The phosphorylation status of various components of the mTOR signal pathway was assessed in peripheral-blood mononuclear cells (PBMCs) isolated from treated patients. Results There were 26 patients enrolled; 18 were assessable. DLTs included diarrhea (n = 1), mucositis (n = 1), and elevation of ALT (n = 1) at 6.5 mg/m 2 . At the MTD of 5 mg/m 2 , the median everolimus clearance was 15.2 L/h/m 2 , with a plasma everolimus concentration-time area under the curve (AUC) from 0 to infinity of 239.6 ng/mL·h. Significant inhibition of mTOR pathway signaling was observed in PBMCs from patients achieving AUCs ≥ 200 ng/mL·h, equivalent to dosages of 3 to 5 mg/m 2 of everolimus. No objective tumor responses were observed. Conclusion Continuous, orally administered everolimus is well tolerated in children with recurrent or refractory solid tumors and demonstrates similar pharmacokinetic properties to those observed in adults. Everolimus significantly inhibits the mTOR signaling pathway in children at the MTD. The recommended phase II dose in children with solid tumors is 5 mg/m 2 .
Welcome to the Nursing Home
Authors: Amy Lee Lipan
Journal: Annals of Internal Medicine (2008)

Ad Libitum2 September 2008Welcome to the Nursing HomeAmy Lee Lipan, MDAmy Lee Lipan, MDFrom Desert Vista Medical Associates, Scottsdale, AZ 85254.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-5-200809020-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail like Mandarin citrus. You can't detect anything that reminds... Author, Article, and Disclosure InformationAffiliations: From Desert Vista Medical Associates, Scottsdale, AZ 85254.Current Author Address: Amy Lee Lipan, MD, Desert Vista Medical Associates, 10900 North Scottsdale Road, #603, Scottsdale, AZ 85254. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 September 2008Volume 149, Issue 5Page: 356KeywordsAlzheimer diseaseDustFoodHygieneNursesNursing homesNutritionSmellTouchUrine ePublished: 2 September 2008 Issue Published: 2 September 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Straddling and Displaced Atrioventricular Orifices and Valves with Primitive Ventricles
Authors: RICHARD R. LIBERTHSON, MILTON H. PAUL, ALEXANDER J. MUSTER, RENÉ A. ARCILLA, FRIEDRICH A. O. ECKNER, MAURICE LEV
Journal: Circulation (1971)

Fourteen cases of straddling or displaced atrioventricular (A-V) orifices and valves are presented. There are three types: (1) straddling tricuspid orifice entering both primitive ventricles with the mitral valve entering the left ventricle (nine cases), (2) displaced tricuspid orifice into the primitive left ventricle, with no A-V orifice in the primitive right ventricle (three cases), and (3) displaced tricuspid orifice with straddling mitral valve, in which the mitral valve has connections in both primitive ventricles, with the tricuspid entering the primitive left ventricle (two cases). Pathologically, these hearts are not single ventricle since there is a primitive right ventricle containing a portion of sinus as well as conus. Embryologically, however, these hearts are related to single ventricle, all being due to insufficient or no passage of the atrial canal region to the right during the process of absorption of the bulbus. Selective angiocardiography may differentiate straddling A-V orifices from single ventricle by showing immediate filling of both ventricles by injection into the right or left atrium.
Should Hyperlipoproteinemia Be Treated In Patients With Coronary Artery Disease?
Authors: Alan K. Rider
Journal: JAMA (1975)

THE RELATIONSHIP between serum lipid levels and the occurrence of coronary atherosclerosis has been adequately analyzed to confirm that elevated serum cholesterol levels and, almost certainly, elevated serum triglyceride levels are among the major risk factors associated with the development of coronary artery disease and myocardial infarction. This concept has been aided by a rational classification of lipid abnormalities based on the characterization of serum lipoproteins. The classification has been most beneficial as a guide to development of logical dietary and pharmacologic regimens for lowering serum lipid concentrations as well as better definitions of both the inheritance and metabolic factors associated with the abnormalities. Type IIa, IIb, and IV hyperlipoproteinemia, all reflecting elevated serum cholesterol or triglyceride levels or both, are associated with the risk of premature atherosclerosis and myocardial infarction. Suitable dietary and drug regimens are available for the control of hyperlipoproteinemia. The temptation to treat an abnormality, in
The use of radionuclide angiography in the diagnosis of coronary artery disease--a logistic regression analysis.
Authors: R J Gibbons, K L Lee, D Pryor, F E Harrell, R E Coleman, F R Cobb, R A Rosati, R H Jones
Journal: Circulation (1983)

We applied logistic regression analysis to a group of 736 patients with chest pain to determine which radionuclide angiographic (RNA) parameters were most useful in the diagnosis of significant coronary artery disease. The most useful parameters were exercise ejection fraction, exercise heart rate, "ischemia score," and the presence of a regional wall motion abnormality at exercise. Ten clinical variables were used in one logistic regression model to estimate each patient's pretest probability of disease. A second logistic regression model considered these clinical variables and the four important RNA parameters to estimate each patient's posttest probability. These models were applied prospectively to a group of 76 patients with chest pain who did not have a high pretest probability of disease. Twenty-four patients (32%) could be diagnosed with 90% probability; 32 patients (42%) could be diagnosed with 85% probability. RNA testing is therefore helpful in the noninvasive diagnosis of coronary artery disease. However, a majority of patients who do have a low or intermediate pretest probability of disease will require additional testing for a definitive diagnosis.
Antiemetics and cytotoxic drugs.
Authors: J R Trounce
Journal: BMJ (1983)

effective if given intravenously,34 while dichloromethylene bisphosphonate34 35 and aminohydroxypropylidine bisphos- phonate36 are effective by mouth or intravenously.Un- fortunately none of these preparations is generally available at present.The crucial principle of management is that treatment of disequilibrium hypercalcaemia takes priority over investigation.The aim must be to reduce serum calcium to a safe but not necessarily normal concentration (say, below 3 mmol/l; 12 mg/100 ml) while investigations are completed and definitive treatment planned.
Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion.
Authors: I M Dauber, K M VanBenthuysen, I F McMurtry, G S Wheeler, E J Lesnefsky, L D Horwitz, J V Weil
Journal: Circulation Research (1990)

Although morphological studies suggest that coronary vascular injury is a result of prolonged ischemia and subsequent reperfusion, whether functional coronary microvascular injury develops during brief in vivo ischemia is unclear. In other organs, permeability is a sensitive indicator of functional vascular injury. Therefore, a new double-indicator method of assessing vascular protein permeability, a method that is both sensitive and specific for vascular injury, was used to investigate the effects of ischemia of graded duration followed by reperfusion on coronary microvascular function. To help confirm functional coronary vascular injury, endothelium-dependent vasodilation of isolated coronary vascular rings also was examined. Microvascular permeability was quantitatively assessed as a protein leak index by measuring the rate of extravascular accumulation of radiolabeled protein (indium 113m transferrin) normalized for vascular surface area (technetium 99m erythrocytes). Anesthetized dogs underwent 0 (control), 15, 30, or 60 minutes of left anterior descending coronary artery occlusion followed by 60 minutes of reperfusion. Even 15 minutes of ischemia increased the protein leak index by 50% (3.16 +/- 0.30 ischemic vs. 2.09 +/- 0.11 control). Longer periods of ischemia increased the protein leak index in proportion to the duration of ischemia. The protein leak index increased threefold (6.51 +/- 0.60) after 60 minutes of ischemia. At each duration of ischemia, there was significant regional variation in the protein leak index that correlated with the severity of ischemic blood flow to that region measured with microspheres. Endothelial injury also was evident after 15 and 30 minutes of ischemia as impaired vasodilation of isolated coronary rings in response to the endothelium-dependent vasodilators acetylcholine and the calcium ionophore A23187. Electron microscopy and in vitro direct immunofluorescence revealed evidence of vascular injury after 60 minutes but not after 15 minutes of ischemia. We conclude that even brief ischemia and reperfusion cause functional coronary vascular injury evident as increased microvascular permeability and impaired endothelium-dependent vasodilation and that regional differences in the degree of microvascular injury correlate with differences in the severity of ischemia.
Abstract 3482: Validation of novel therapeutic targets for T-cell non-Hodgkin lymphoma
Authors: Daisuke Ito, Timothy D. O'Brien, Jaime F. Modiano
Journal: Cancer Research (2012)

Abstract T-cell malignancies account for 10-15% of all human non-Hodgkin lymphomas (NHL). T-cell lymphomas are incurable, and the development of effective treatment strategies has been hindered by the relatively infrequency of these conditions. T-cell lymphomas occur spontaneously in dogs; they are morphologically similar to human T-cell lymphomas, resemble their biological behavior, and are relatively common (∼35% of all NHL), providing opportunities to improve our understanding of the pathogenesis of these tumors as well as to develop more effective therapies. Tumor-initiating cells (TICs) influence tumor progression and response to therapy in many cancers, so eliminating these cells may be necessary to achieve durable remissions. However, the existence of TICs and their potential significance have not been conclusively established in T-cell NHL. The objective of this study was to evaluate the existence of progenitor-like lymphoma cells (PLCs) in naturally occurring canine T-cell NHL. We identified a reproducible population of tumor-related PLCs in spontaneous T-cell malignancies. The cells expressed the hematopoietic progenitor antigen CD34 and tumor-specific T-cell receptor gene rearrangements. Somewhat unexpectedly, these cells also express B-cell surface proteins (CD20 and CD22), but not the major T-cell surface antigens (CD3 and CD5) that were expressed by the bulk of the tumor cells (BTCs). We have adapted a xenotransplantation assay for primary canine T-cell NHL using NOD/SCID/IL-2Rgammanull mice and genetically modifying the tumor cells to express luciferase as a means monitor tumor growth and distribution by in vivo imaging. This model allows us to expand and serially transplant primary canine T-cell NHL for more detailed studies, including limiting dilution assays and therapeutic targeting using anti-B-cell reagents. In summary, we propose a novel concept in which a small population of tumor cells with “B-cell progenitor” phenotypes may paradoxically contribute to the pathogenesis of T-cell lymphoma, potentially representing a novel therapeutic target. We already use dogs with naturally occurring disease in the pathway for therapy development, allowing us to expand these studies into clinical trials that can then be rapidly translated to benefit human patients (for example, by using approved agents such as anti-CD20 antibodies or CD22-targeted immunotoxins). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3482. doi:1538-7445.AM2012-3482
OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS
Authors: Ivan L. Bennett
Journal: The Journal of Experimental Medicine (1948)

The relationship of the fever caused in rabbits by bacterial pyrogens to the fever produced by the injection of the sterile exudates of acute inflammation was investigated by recording the responses of normal and pyrogen-tolerant animals to injections of exudate. Exudates were produced by the intrapleural injection of turpentine in dogs. The duration of the febrile response in rabbits after a single dose of exudate was found to be much shorter than the fever following an injection of bacterial pyrogen. Animals given daily injections of exudate demonstrated no tolerance to its fever-promoting effect. Animals tolerant to bacterial pyrogens showed no diminution in responsiveness to exudates. Daily injections of exudate failed to establish tolerance to bacterial pyrogens in rabbits. It is concluded that the fever-promoting property of sterile exudates is not due to the presence of bacterial pyrogen.
The virological and histological states of anti-hepatitis C virus?positive subjects with normal liver biochemical values
Authors: M SHINDO
Journal: Hepatology (1995)

We investigated anti-hepatitis C virus (HCV) titers, HCV RNA levels in liver and serum, genetic variability in the hypervariable region of the genome, the form of the virus in the circulation, and liver histology in 21 anti-HCV-positive subjects with sustained normal liver biochemical values. Titer of anti-HCV was determined by second generation anti-HCV-passive hemagglutination assay, and HCV RNA levels were semiquantitated by reverse transcriptase polymerase chain reaction (PCR). In 19 (90%) of the 21 subjects who had a higher titer of anti-HCV (> or = 2(14)), HCV RNA was detected in both serum and liver, and histological examination showed minimal or mild chronic hepatitis in all. In the remaining 2 patients who had a lower titer of anti-HCV, HCV RNA was not detected in serum and liver, and liver histology was normal. Anti-HCV titers and HCV RNA levels in serum and liver in the 19 HCV RNA-positive subjects were compared with those levels in the 41 patients with biopsy-proven chronic hepatitis C and elevated serum aminotransferase levels as a control group. There were no significant differences in viral levels in serum and liver between the two groups. To further investigate virological differences between the two groups with regard to degree of genetic variability and the form in the circulation, we performed the PCR-single strand conformation polymorphism (PCR-SSCP) of the hypervariable region 1 and the immunoprecipitation analyses.(ABSTRACT TRUNCATED AT 250 WORDS)
The AIDS Epidemic
Authors: David G. Ostrow
Journal: JAMA (1983)

Donald Fredrickson begins his overview of the government's role to date in AIDS research by stating: "One by one the experts have come to tell us what they know about this calamity, and by aligning the fragments differently we can catch various views of its dimensions.<i>They are frightening</i>" (emphasis added by reviewer). It is barely three years since the first clusters of Kaposi's sarcoma and<i>Pneumocystis carinii</i>pneumonia in homosexually active men were reported, but the acquired immune deficiency syndrome (AIDS) has rapidly advanced to a full-fledged epidemic and billing as the nation's number one health priority. While the cause(s) and prevention of AIDS still remain a mystery, much can be learned by studying the progression of this epidemic.<i>The AIDS Epidemic</i>, a compilation of papers presented at the Lennox Hill Hospital AIDS Symposium, New York, this past March, provides a concise, accurate, and readable account of these events
Mind and Madness in Ancient Greece: The Classical Roots of Modern Psychiatry
Authors: Arnold Goldberg
Journal: JAMA (1981)

When I was in grade school and high school, and would frequently encounter the word "ibid" in various books, I assumed it was just another one of those Greek stories, like<i>The Odyssey</i>and<i>The Iliad</i>. With that kind of classical education, you can imagine the apprehension with which I approached<i>Mind and Madness in Ancient Greece</i>, an attempt to trace the classical roots of modern psychiatry. The author is a psychoanalyst who has happily joined what are obviously the two great intellectual loves of his life: the Greek classics and a contemporary view of mental illness. He has also succeeded in calming the fears of those of us who felt that such a marriage had no hope of our personal blessing or comprehension or that we might not even stay awake during the ceremony. This book, by Dr Bennett Simon, communicates the author's enthusiasm for his subject and reading
Recovery from Acute Renal Failure and Acidosis in Sickle-Cell Disease
Authors: Peter F. Salisbury
Journal: JAMA (1960)

A patient with sickle-cell disease underwent cholecystectomy which was followed by a hypotensive episode and renal failure. During the period of progressively increasing azotemia, abnormally low arterial blood pH (metabolic acidosis) was associated with coma, convulsions, and focal signs of central nervous injury. These neurological signs receded when the acidemia was corrected, even though the azotemia continued to increase; central nervous injury was believed to be caused by sickle-cell crisis and not by uremic toxicity. The treatment for renal failure and uremia included the addition of large amounts of hydrocortisone and the frequent measurement and correction of blood pH and urine pH. This is believed to be the first reported instance of recovery from renal failure in a patient with sickle-cell disease.