tbuckley/cabot-search huggingface dataset:
47 TOLL-LIKE RECEPTOR-9 ACTIVATION BY CPG OR P-DNA AMELIORATES HEPATIC FIBROSIS; ASSOCIATED WITH LYMPHOCYTE ALTERATIONS
Authors: J.H. Axelrod, E. Khvalevsky, S. Doron, J. Enk, Y. Nechemia, O. Pappo, E. Galun, R. Safadi
Journal: Journal of Hepatology (2008)
Myocardial Blood Flow and Exercise ECG in Cinearteriographically Demonstrated Coronary Artery Disease.
Authors: Betty C. Corya
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Myocardial Blood Flow and Exercise ECG in Cinearteriographically Demonstrated Coronary Artery Disease.Betty C. Corya, M.D., Suzanne B. Knoebel, M.D., John F. Phillips, M.D., Paul L. McHenry, M.D.Betty C. Corya, M.D.Search for more papers by this author, Suzanne B. Knoebel, M.D.Search for more papers by this author, John F. Phillips, M.D.Search for more papers by this author, Paul L. McHenry, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-818_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe response of myocardial blood flow to right atrial pacing and isoproterenol was correlated, in 75 patients, with the severity of arteriographic coronary disease, quantitated by number and severity of vessels involved (coronary artery index) and the ECG response during treadmill exercise. Right atrial pacing has been shown previously to increase myocardial blood flow from 10% to 58% in normal subjects. Of the 16 patients in this study 9 were unable to increase myocardial blood flow with right atrial pacing (+3 to -27%); 8 had 1 positive and 1 equivocal treadmill exercise (P< 0.001). The coronary artery index in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Betty C. Corya, M.D.; Suzanne B. Knoebel, M.D.; John F. Phillips, M.D.; Paul L. McHenry, M.D.Affiliations: Indianapolis, Ind. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 818-819KeywordsBlood flowCoronary arteriesExerciseIsoproterenolPatient advocacyStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
An introduction to the indirect exposure assessment approach: modeling human exposure using microenvironmental measurements and the recent National Human Activity Pattern Survey.
Authors: N E Klepeis
Journal: Environmental Health Perspectives (1999)

Indirect exposure approaches offer a feasible and accurate method for estimating population exposures to indoor pollutants, including environmental tobacco smoke (ETS). In an effort to make the indirect exposure assessment approach more accessible to people in the health and risk assessment fields, this paper provides examples using real data from (italic&gt;a(/italic&gt;) a week-long personal carbon monoxide monitoring survey conducted by the author; and (italic&gt;b(/italic&gt;) the 1992 to 1994 National Human Activity Pattern Survey (NHAPS) for the United States. The indirect approach uses measurements of exposures in specific microenvironments (e.g., homes, bars, offices), validated microenvironmental models (based on the mass balance equation), and human activity pattern data obtained from questionnaires to predict frequency distributions of exposure for entire populations. This approach requires fewer resources than the direct approach to exposure assessment, for which the distribution of monitors to a representative sample of a given population is necessary. In the indirect exposure assessment approach, average microenvironmental concentrations are multiplied by the total time spent in each microenvironment to give total integrated exposure. By assuming that the concentrations encountered in each of 10 location categories are the same for different members of the U.S. population (i.e., the NHAPS respondents), the hypothetical contribution that ETS makes to the average 24-hr respirable suspended particle exposure for Americans working their main job is calculated in this paper to be 18 microg/m3. This article is an illustrative review and does not contain an actual exposure assessment or model validation.
Tromso Heart Study: vitamin D metabolism and myocardial infarction.
Authors: B Vik, K Try, D S Thelle, O H Forde
Journal: BMJ (1979)

Troms4 Heart Study: vitamin D metabolism and myocardial infarctionThe high mortality rates from myocardial infarction in northern Norway lead to the establishment of the Tromso Heart Study (THS) in 1974.1An investigation by Linden,2 suggested that a high intake of vitamin D might be a precipitating cause of myocardial infarction in this area of Norway.We therefore studied data from the THS to determine whether vitamin D was a risk factor for myocardial infarction.
Book Review Fixing Sex: Intersex, Medical Authority, and Lived Experience By Katrina Karkazis. 365 pp. Durham, NC, Duke University Press, 2008. $84.95 (cloth); $23.95 (paper). 978-0-8223-4302-8 (cloth); 978-0-8223-4318-9 (paper).
Authors: Gary Berkovitz
Journal: New England Journal of Medicine (2009)
Studies on in vitro chrysotile-pleural mesothelial cell interaction: morphological aspects and metabolism of benzo-3,4-pyrene.
Authors: M C Jaurand, I Bastie-Sigeac, L Magne, M Hubert-Habart, J Bignon
Journal: Environmental Health Perspectives (1983)

Cultures of rat pleural mesothelial cells (PMC) were exposed to nonlethal doses of UICC chrysotile A. The morphology was studied by optical and electron microscopy. The consequences of chrysotile ingestion on the rate of pinocytosis of horseradish peroxidase (HPR) metabolism and benzo-3-4-pyrene (BP) were studied. Nonlethal doses of chrysotile (5 micrograms/mL) induced a time-dependent vacuolation of PMC; a dose-dependent inhibition of the vacuolation was observed when PMC were pretreated with DMSO. The origin of the vacuoles is not clear, but some features of autophagy and lysosomal storage were observed. Chrysotile fibers did not modify the rate of pinocytosis of HRP. Similarly, the metabolism of BP was unchanged when BP and chrysotile were both added to the culture medium or when PMC were preincubated with the fibers 24 hr prior to the addition of BP.
One doctor's conversion to running
Authors: Lindsay Easton
Journal: British Journal of Sports Medicine (2000)

Objectives-To study factors associated with passive hip rotation range of motion (ROM) in former elite male athletes.Methods-Athletes were interviewed about hip pain, disability, lifetime occupational loading, and athletic training.The passive hip rotation was measured with a Myrin inclinometer in 117 former elite male long distance runners, soccer players, weight lifters, and shooters aged 45-68 years.Magnetic resonance imaging was used to detect hip osteoarthritis.Results-There were no diVerences in passive hip rotation ROM between the four athlete groups nor between diverging lifetime loading patterns associated with occupational or athletic activities.Among the subjects without hip osteoarthritis, hip pain, and hip disability according to a stepwise linear regression analysis, the only factor that was associated with the passive hip rotation ROM was body mass index (BMI), explaining about 21% of its variation.Subjects with high BMI had lower passive hip rotation ROM than those with low BMI.There was no right-left difference in the mean passive hip rotation ROM in subjects either with or without hip osteoarthritis as determined by magnetic resonance imaging.Nevertheless, hip rotation ROM was clearly reduced in a few hips with severe caput deformity.Conclusions-Long term loading appears to have no association with passive hip rotation ROM.On the other hand, the hip rotation value was lower in subjects with high BMI than in those with low BMI.A clear right-left diVerence in hip rotation was found only in those subjects who, according to our magnetic resonance imaging criteria, had severe hip osteoarthritis.These findings should be taken into account when hip rotation ROM is used in the clinical assessment of hip joints.
Effects of various vacuum cleaners on the airborne content of major cat allergen (Fel d 1)
Authors: F. de Blay, F. Spirlet, P. Gries, S. Casel, M. Ott, G. Pauli
Journal: Allergy (1998)

It has been shown that a vacuum cleaner (VC) can increase airborne cat allergen levels. This study aimed to compare the degree of leakage of airborne Fel d 1 levels among five different VCs, both under laboratory conditions and in an apartment with cats.Three of the VCs were marketed as antiallergic: a HEPA filter VC (VC A), a water impingement and HEPA filter VC (VC B), and a foam fabric filter VC (VC C). The other two were standard VCs: VC D and VC E. VCs were tested in a 20 m3, airtight, experimental room and in a 53 m3 living room in an apartment with three cats. Air was sampled with a glass-fiber filter and an impinger at 20 l/min for 30 min before, during, and after vacuuming. Airborne Fel d 1 was measured with a two-site monoclonal ELISA assay.In the experimental room, no airborne Fel d 1 level was measured before using the VCs. After introducing a dust sample containing Fel d 1 in the VCs, we found that VCs A, B, and E did not provoke any increase in airborne Fel d 1. In contrast, VCs C and D significantly increased airborne Fel d 1 levels (GM: 4.9 and 5.3 ng/m3, respectively). In the apartment, all VCs induced an increase in airborne Fel d 1, which was carried by particles greater than 5 microm. However, VCs C and D provoked significantly greater increases in airborne Fel d 1 than VCs A, B, and E (P=0.0001).Our results suggest that: 1) The two VCs with leakage in the experimental room had greater leakages in the apartment. 2) In the apartment with cats, all VCs provoked increases in airborne Fel d 1, primarily carried by large particles. 3) Given the increased marketing of "antiallergic" VCs, further studies are needed to standardize methods for testing airborne allergen leakage by VCs.
Prevention of warfarin induced skin necrosis
Authors: JOHN D. KIRBY, R.L. BREARLEY
Journal: British Journal of Dermatology (1978)

Journal Article Prevention of warfarin induced skin necrosis Get access JOHN D. KIRBY, JOHN D. KIRBY Department of Dermatology St Bartholomew's Hospital, London EC1 Search for other works by this author on: Oxford Academic Google Scholar R.L. BREARLEY R.L. BREARLEY Department of Haematology St Bartholomew's Hospital, London EC1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 98, Issue 6, 1 June 1978, Page 707, https://doi.org/10.1111/j.1365-2133.1978.tb03594.x Published: 01 June 1978
1034-208 Enalapril can prevent perpetuation of atrial fibrillation through suppression of interstitial fibrosis and connex 43 expression associated with shortening of excitable gap in a canine rapid atrial pacing model with tachycardia mediated cardiomyopathy
Authors: Masao Sakabe, Akira Fujiki, Kunihiro Nishida, Hidehiko Nagasawa, Koichi Mizumaki, Hiroshi Inode
Journal: Journal of the American College of Cardiology (2004)
Localization of hepatitis C virus antigens in liver and skin tissues of chronic hepatitis C virus–infected patients with mixed cryoglobulinemia
Authors: Domenico Sansonno, Vito Cornacchiulo, Anna Rina Iacobelli, Rita Di Stefano, Mario Lospalluti, Franco Dammacco
Journal: Hepatology (1995)

Skin and/or liver biopsy specimens were obtained from the following patients: 15 anti-hepatitis C virus (HCV), HCV RNA-positive patients and 3 anti-HCV, HCV RNA-negative patients with type II mixed cryoglobulinemia (MC); 7 anti-HCV, HCV RNA-positive patients with chronic active liver disease (CALD); 5 anti-HCV, HCV RNA-negative patients with noncryoglobulinemic vasculitis; and 7 anti-HCV, HCV RNA-negative patients with lichen ruber planus. A pool of murine monoclonal antibodies (MAbs) developed against c22-3, c33c, and c100-3 proteins was used to detect HCV-related antigens (Ags) by indirect immunohistochemistry. Acid electroelution (AEE) of tissue sections was performed to enhance the sensitivity of the immunohistochemical method. In anti-HCV-positive MC patients, specific HCV-related Ags were detected in the small vessels of the skin and in the cytoplasm of hepatocytes. Prior AEE of biopsy sections allowed detection of HCV Ags in 6 of 15 (40%) skin biopsy and in 9 of 14 (64.3%) liver biopsy specimens. HCV immunoreactive deposits in the skin displayed two immunohistochemical patterns: (1) coarse intraluminal material associated with dermal inflammatory infiltrates and intravascular deposition of eosinophilic hyaline material; and (2) reactivity confined to the vessel wall in the context of an apparently normal tissue. Immunoglobulin (Ig) G and IgM deposition in the skin showed immunohistochemical features comparable with those found for HCV Ag deposits.(ABSTRACT TRUNCATED AT 250 WORDS)
Proposed guidelines for severe imported malaria in children need more evidence
Authors: Shamez Ladhani, Delane Shingadia, F Andrew I Riordan
Journal: BMJ (2005)

EDITOR—The proposed UK guidelines for severe childhood malaria are an excellent attempt to improve the care of children with severe imported malaria,1 but we are concerned about the following.

Firstly, the use of parenteral antibiotics. The “high risk group” would include less than 5% of children with imported malaria.2 Children with these features in the United Kingdom are likely to have bacterial septic shock or meningitis, …
A theme issue for medics and an increasingly health informed public
Authors: L. Eaton
Journal: BMJ (2002)

What might it be like to practise medicine in 10 years' time—and how best should a medical journal reflect that? We have been wondering what the BMJ might look like by 2013—not just whether it will still appear in print or only on the web, but whether it should still be aimed primarily at doctors. Perhaps it should appeal to the new and growing audience of well informed patients—and, indeed, an increasingly health-savvy general public as well? We are planning an experiment in our issue of the journal next June which will aim for the first time to appeal to a wider audience than just the medical profession.

This is not a gimmick: it is born out of a conviction that the interaction between the public and the medical profession will change markedly in the …
ESTIMATION OF THE PHOSPHOLIPID PHOSPHORUS TURNOVER TIME IN MAN: STUDIES IN NORMAL INDIVIDUALS, IN PATIENTS WITH THE NEPHROTIC SYNDROME AND IN OTHER TYPES OF HYPERLIPEMIA 1
Authors: Hugo W. Moser, Kendall Emerson
Journal: Journal of Clinical Investigation (1955)

The purpose of this study is to contribute to an understanding of the mechanism of production of various types of hyperlipemia by comparing the plasma phospholipid turnover time in normal individuals and in patients with elevated plasma lipids. The rate of incorporation of a single tracer dose of P32 labeled carrier-free inorganic phosphate into the plasma phospholipids has been measured and a mathematical procedure described by Zilversmit, Entenman, and Fishler (1) has been used for the calculation of the turnover time of the sum of phospholipid phosphorus contained in the plasma and liver. Results obtained in six normal individuals, in five patients with the nephrotic syndrome and in three patients with hyperlipemia due, respectively, to hypothyroidism, biliary cirrhosis and essential familial xanthomatosis will be presented.
Health Plan: The Only Practical Solution to the Soaring Cost of Medical Care
Authors: Theodore R. Marmor
Journal: JAMA (1980)

Alain Enthoven's book, we are told by the subtitle, is "the only practical solution to the soaring cost of medical care," a "brilliantly simple approach to better care and lower costs." No doubt public relations hypsters wrote this breathless prose, but the author should never have let them. For the solution Enthoven suggests to health problems in the United States is neither simple nor brilliant. And the book he has written is not so much his remedy for our ills as his diagnosis of them. Enthoven first explains why medical care expenditures have increased so dramatically in the last quarter century, and the account he gives constitutes the most literate I know. He is at pains to show how almost all incentives press in the direction of higher costs. He is equally at pains to show that although the growth of insurance—public and private—has supported the increased spending, deductibles and
Crohn's disease presenting as anorexia nervosa
Authors: A P Jenkins, J Treasure, R P H Thompson
Journal: BMJ (1988)

<h3>Background</h3> The scale-up of HCV treatment for HIV/HCV coinfected individuals is occurring, the majority with a history of injecting drug use. <h3>Purpose</h3> We assess the implications for achieving the World Health Organisation HCV incidence elimination target (80% reduction from 2015–2030) among HIV-infected (HIV+) people who inject drugs (PWID) and all PWID, using dynamic modelling. <h3>Material and methods</h3> A joint HIV and HCV transmission model among PWID was based on published data and the HERACLES cohort (prospective cohort of HIV/HCV coinfected individuals in care from 2015–2017). The model was stratified by HIV stage, HCV stage and PWID status (young PWID (&lt;10 years’ injecting), old PWID (&gt;10 years’ injecting), ex PWID). We simulated: 45%/60% chronic HCV prevalence and 20%/40% HIV prevalence among PWID injecting for &lt;10 years and &gt;10 years, respectively, 54% chronic HCV among HIV +ever PWID (PWID +ex PWID). We assumed HCV treatment among diagnosed coinfected ever-PWID of 10.5%/year from 2004–2014, and 33%/year from 2015 (from HERACLES). We projected the impact of current treatment, and scaled-up treatment (among HIV +PWID or all PWID) from 2018 on HCV prevalence/incidence among HIV +PWID and all PWID. <h3>Results</h3> We projected that 28% and 32% of HCV +PWID and HCV +ex PWID, respectively, were HIV/HCV coinfected in 2015. Current treatment rates could reduce the number of diagnosed coinfected PWID by 75% from 2015–2030. However, this would only reduce HCV incidence by a relative 25% and 16% among HIV +PWID and all PWID, respectively. If all coinfected PWID were diagnosed and treated annually from 2018, this could reduce chronic HCV prevalence by 74% among HIV+ PWID by 2030, but only halve the incidence. Greater impact could be achieved through scaling-up treatment to all PWID. <h3>Conclusion</h3> HCV elimination among HIV +PWID will not be achieved by treating coinfected PWID alone: efforts should focus on HCV diagnosis and treatment among both coinfected and monoinfected PWID. Scaling-up treatment to all PWID. <h3>References and/or acknowledgements</h3> No conflict of interest.
Ireland is told to provide legal abortions for women whose lives are at risk
Authors: C. Dyer
Journal: BMJ (2010)

Women in the Irish Republic will have to be given the means to access legal abortions there if their lives are at risk, the European Court of Human Rights has ruled in a landmark judgment.

The ruling, by the grand chamber of the Strasbourg court, can not be appealed and will require Ireland to legislate or otherwise set up a framework to decide whether there is a “real and substantial risk” to a woman’s life if she goes ahead with her pregnancy.

The court held that the human rights of a woman with a rare cancer were violated when she was obliged to travel to the United Kingdom for an abortion and awarded her €15 000 (£12 700; $19 800) in …
Hysteria: The History of a Disease
Authors: Henry W. Brosin
Journal: JAMA (1966)

Physicians, humanists, and behavioral scientists everywhere will welcome this distinguished contribution to the understanding of several phases of perplexing human behavior over a period of 4,000 years. As more materials, including works of art, become available for tracing the transformations of human aberrations over several millenia, it is increasingly possible to study those areas in terms of current insights. Professor Veith, a well-known medical historian, is superbly equipped for this monumental task. She was a pupil of Henry Sigerist and dedicates this book to him. In the best Sigerist tradition she describes the socioeconomic, political, medical, and philosophic backgrounds against which we can see the basic dynamics of a process or reaction type commonly called hysteria.  Beginning with Egyptian medical papyri, of about 1900 BC, which describe morbid states attributed to the displacement of the uterus, Professor Veith traces the persistence of this concept into modern times. The underlying theme
Amoxicillin for non-severe pneumonia in young children:Stop skimping, start investing in antibiotic treatment
Authors: Lynne Wrennall
Journal: BMJ (2004)

EDITOR—The limitations of the paper on three v five days of antibiotic treatment for pneumonia merit additional emphasis.1 The paper had an inadequate selection of indicators of treatment failure, an insufficiently discriminating treatment comparison (also pointed out by Borja and Rigau (next letter)), insufficient detailing of patients' history, dismissiveness towards caregivers' assessments, deficient survivor …
Muscle cell electrical hyperpolarization and reduced exercise hyperkalemia in physically conditioned dogs.
Authors: J P Knochel, J D Blachley, J H Johnson, N W Carter
Journal: Journal of Clinical Investigation (1985)

Contracting muscle cells release K ions into their surrounding interstitial fluid, and some of these ions, in turn, enter venous plasma. Thereby, intense or exhaustive exercise may result in hyperkalemia and potentially dangerous cardiotoxicity. Training not only reduces hyperkalemia produced by exercise but in addition, highly conditioned, long-distance runners may show resting hypokalemia that is not caused by K deficiency. To examine the factors underlying these changes, dogs were studied before and after 6 wk of training induced by running on the treadmill. Resting serum [K] fell from 4.2 +/- 0.2 to 3.9 +/- 0.3 meq/liter (P less than 0.001), muscle intracellular [K] rose from 139 +/- 7 to 148 +/- 14 meq/liter (P less than 0.001), and directly measured muscle cell membrane potential (Em) in vivo rose from -92 +/- 5 to -103 +/- 5 mV (P less than 0.001). Before training, resting Em of isolated intercostal muscle in vitro was -87 +/- 5 mV, and after incubation in 10(-4) M ouabain, Em fell to -78 +/- 5 mV. After training, resting Em of intercostal muscle rose to -95 +/- 4, but fell to -62 +/- 4 mV during incubation in 10(-4) M ouabain. The measured value for the Em was not completely explained by the increased ratio of intracellular to extracellular [K] or by the potassium diffusion potential. Skeletal muscle sarcolemmal Na,K-ATPase activity (microM inorganic phosphate mg-1 protein h-1) increased from 0.189 +/- 0.028 to 0.500 +/- 0.076 (P less than 0.05) after training, whereas activities of Mg2+ -dependent ATPase and 5'nucleotidase did not change. In untrained dogs, exercise to the point of exhaustion elevated serum [K] from 4.4 +/- 0.5 to 6.0 +/- 1.0 meq/liter (P less than 0.05). In trained dogs, exhaustive exercise was associated with elevation of serum [K] from 3.8 +/- 0.3 to 4.2 +/- 0.4 (NS). The different response of serum [K] to exercise after training was not explainable by blood pH. Basal insulin levels rose from 7.0 +/- 0.7 microU/ml in the untrained dogs to 9.9 +/- 1.0 microU/ml (P less than 0.05) after training. Although insulin might have played a role in the acquired electrical hyperpolarization, the reduced exercise-produced hyperkalemia after training was not reversed by blockade of insulin release with somatostatin. Although the fundamental mechanisms underlying the cellular hyperpolarization were not resolved, our observations suggest that increased Na-K exchange across the sarcolemmal membrane, the increase of Na,K-ATPase activity and possibly increased electrogenicity of the sodium pump may all play a role in the changes induced by training.