tbuckley/cabot-search huggingface dataset:
Abstract 3099: Dual targeting of mTOR and Notch disrupts growth and promotes apoptosis in diffuse intrinsic pontine glioma
Authors: Isabella C. Taylor, Marianne Hutt-Cabezas, Melanie Weingart, Kathy Warren, Howard Chang, Javad Nazarian, Charles G. Eberhart, Eric H. Raabe
Journal: Cancer Research (2014)

Abstract Diffuse intrinsic pontine gliomass (DIPGss) account for 10% of pediatric brain tumors and have a universally poor prognosis. Our laboratory has shown that targeting the NOTCH pathway in glioblastoma (GBM) with gamma secretase inhibitors (GSI), inhibits the growth and viability of tumor neurospheres. Primary DIPG as well as DIPG cell lines express have very high levels of NOTCH activity as measured by western blot and qPCR assays. AKT amplification is observed in primary DIPG, and TORC1/TORC2 activation occurs in DIPG cell lines as measured by western blot. The mTOR and NOTCH pathways are known to interact and alter cancer stem cell growth, stemness, and metabolism. We hypothesized that dual targeting of NOTCH and mTOR in DIPG would lead to decreased proliferation and increased apoptosis compared to targeting either pathway in isolation. In established DIPG cell lines, we observed that GSI treatment decreases NOTCH activity in a dose dependent manner as evidenced by decreased expression of NOTCH targets expression of Hes1 and Hey1 via as measured by western blot and qPCR assays. We also observed a dose-dependent reduction in DIPG proliferation and growth after gamma-secretase inhibition as measured by BrdU (Day 7, DMSO to 5 uM MRK003 had p value &amp;lt;0.05) and MTT assays (Day 5 and Day 7, DMSO to 2 uM and 5 uM MRK003 p value &amp;lt;0.05). However, inhibition of growth and increased apoptosis were not complete. We observed a similar decrease in proliferation and increase in apoptosis using the dual TORC1/TORC2 inhibitor PPT242. Combination therapy with MRK003 and PP242 led to significantly increased apoptosis compared to either treatment alone (cell cycle Sub-G1: DMSO 13.2% vs 1000nM PP242-5uM M003 28.9%). This data suggest that dual targeting of the mTOR and NOTCH pathways with GSI will decrease DIPG cell growth and proliferation, increase cell death, and reduce tumorigenicity. Citation Format: Isabella C. Taylor, Marianne Hutt-Cabezas, Melanie Weingart, Kathy Warren, Howard Chang, Javad Nazarian, Charles G. Eberhart, Eric H. Raabe. Dual targeting of mTOR and Notch disrupts growth and promotes apoptosis in diffuse intrinsic pontine glioma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3099. doi:10.1158/1538-7445.AM2014-3099
Abstract 320: Low Prevalence of Ischemia and Excellent Prognosis in an Intermediate-Risk Cohort Achieving >=10 METS on Exercise Myocardial Perfusion Imaging: Was SPECT Imaging Necessary?
Authors: Jamieson M Bourque, George T Charlton, Benjamin H Holland, Christopher M Belyea, Denny D Watson, George A Beller
Journal: Circulation (2009)

Introduction: Increasing yearly volumes of stress myocardial perfusion imaging (MPI) are a cost burden on the healthcare system. The benefit of MPI over exercise electrocardiography is unclear in individuals attaining a high cardiac workload of ≥10 METS. The purpose of this study was to determine the 1-year outcomes in this cohort at intermediate risk for CAD or with known CAD (11.1%) achieving ≥10 METS regardless of peak exercise heart rate. Methods: Ischemia and LV function were obtained by quantitative gated 99mTc-SPECT MPI in 554 consecutive patients reaching ≥10 METS of exercise workload. One-year rates of all-cause mortality, cardiovascular (CV) death, and non-fatal myocardial infarction (MI) were prospectively-collected through mailed questionnaires, patient and physician telephone contact, patient records, and the social security death index. Results: All-cause mortality and CV death were ascertained in 504 of 554 patients (91.0%) and non-fatal MI in 459 subjects (82.9%). No difference was observe...
A Case of Roentgen Photography
Authors: H. Marsh
Journal: BMJ (1896)

MAY 30, i896 is the most important, as it is in truth the resultant of many other factors."My attention was attracted by the repeated coincidence of wlhat are called " colliery warnings," appearing in the daily papers, with urgent messages to attend patients attacked with hw3morrhage from the lungs.The coincidences were so frequent that I could not avoid concluding that there was some connection between the one and the other.Time after time cases have arisen either immediately before I saw the "warning" or very often on the day that the public notice appeared.From these notices I naturally turned to the birometer, to learn that in almost every case the pressure of the atmosphere was exceptionally high.At first my attention was taken up almost entirely by cases of hemoptysis; but, as the apparent cause began to impress itself on my mind, hiemorrhages, less striking at first, arrested Interest.From the observations I have made from time to time during the past few years, I have come to the conclusion that there is a marked affinity between a high barometer and hl-morrliages of various kinds.My earlier notes are missing, but the following compressed particulars of recent cases will bear out my statement as to the close relation that appears to exist between a high barometric pressure and the tendency to rupture of blood vessels that are not in a healthy condition.
Recombinant interferon gamma therapy for atopic dermatitis
Authors: Jon M. Hanifin, Lynda C. Schneider, Donald Y.M. Leung, Charles N. Ellis, Howard S. Jaffe, Allen E. Izu, Louis R. Bucalo, Sue E. Hirabayashi, Susan J. Tofte, Graciela Cantu-Gonzales, Henry Milgrom, Mark Boguniewicz, Kevin D. Cooper
Journal: Journal of the American Academy of Dermatology (1993)
SOME INCIDENTS IN THE EVOLUTION OF THE MODERN PHYSICIAN.
Authors: WILLIAM ALFRED ELLISTON
Journal: JAMA (1900)

The president commenced his address with notice of the associations of Ipswich and the deaths of Drs. Stewart and Paget, then passed to the subject of development of British medicine, which was the theme of his address. The early history of medicine in England is that of the Dark Ages; and down to the commencement of the sixteenth century, England had taken no part in the scientific advance of the century, and for almost one hundred years later no discovery of any importance was due to English research. The commencement of British medicine he dates from the return of Thomas Linacre to Oxford from the Italian universities, whence he came imbued with what was termed "new learning." The great event in the sixteenth century, so far as medicine was concerned, was the success of Linacre in persuading the king to grant a charter to a small body of medical graduates,
The Treatment of Acute Otitis Media in Children
Authors: Gunnar B. Stickler, James B. McBean
Journal: JAMA (1964)

An attempt was made to evaluate the effectiveness of five antimicrobial agents in the management of 463 episodes of acute otitis media. Results were not discernibly different with tetracycline, erythromycin estolate, a "long-acting" mixture of penicillin G salts, and demethylchlortetracycline hydrochloride; not more than 6% to 15% of patients who received these agents required additional therapy. Administration of a triple sulfonamide preparation resulted in a failure rate of 22%, which was significantly higher than the failure rate in patients treated with tetracycline. No complications such as mastoiditis or meningitis were encountered, and myringotomy was performed in only four patients.
Beyond Fraud — Stem-Cell Research Continues
Authors: Evan Y. Snyder, Jeanne F. Loring
Journal: New England Journal of Medicine (2006)

The developments in the laboratory of Woo Suk Hwang of Seoul National University in South Korea are profoundly disappointing to all scientists. Dr. Evan Snyder and Jeanne Loring write that although the events of Hwang's story provide a case study of some of the worst aspects of high-profile, high-stakes global science, they also include some reassuring elements.
Perfluorocarbon broncho-alveolar lavage and liquid ventilation versus saline broncho-alveolar lavage in adult guinea pig experimental model of meconium inhalation
Authors: G. Marraro, M. Bonati, A. Ferrari, M. M. Barzaghi, C. Pagani, A. Bortolotti, A. Galbiati, M. Luchetti, A. Croce
Journal: Intensive Care Medicine (1998)
BTNL2 gene variant and sarcoidosis
Authors: Y Li
Journal: Thorax (2006)

disorders and ischaemic heart disease, the ITT is a safe test when performed in experienced centres. 3 Indeed, a review of .6500ITTs reported that only seven patients (0.1%) experienced an adverse event, all of which reversed following intravenous glucose. 6To our knowledge, only two studies have used the ITT to investigate the HPA axis in asthmatic children treated with inhaled fluticasone.The first reported an inadequate response to insulin-induced hypoglycaemia in three children taking 1000-2250 mg/day. 7In the second study, nine of 18 subjects treated with 250-750 mg/day for up to 16 weeks exhibited evidence of adrenal suppression which recovered following cessation of treatment. 1 Finally, as hypopituitarism of probable autoimmune aetiology has been reported in patients with celiac disease, 8 the possibility that autoimmune hypophysitis contributed to the patients' symptoms and pituitary deficiency cannot be definitively excluded.In summary, this report suggests that inhaled (together with intranasal) fluticasone may suppress the HPA axis in adults and that symptomatic adrenal insufficiency may develop, particularly if dosing is variable and intermittent.These cases illustrate that clinical symptoms may alert the physician to the possibility of adrenal suppression which can then be confirmed using basal and/or stimulated tests of HPA function in selected patients.Further investigation to determine the prevalence of these effects in adult patients is warranted.
Hot Flash(er)
Authors: John Pidgeon
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WILD-TYPE GROSS LEUKEMIA VIRUS AND THE PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NEW ZEALAND MICE
Authors: Robert C. Mellors, Toshikazu Shirai, Tadao Aoki, Robert J. Huebner, Krzysztof Krawczynski
Journal: The Journal of Experimental Medicine (1971)

The pathogenesis of the spontaneous glomerulonephritis of NZB and (NZB x NZW) F(1) hybrid mice is related at least in part to the formation of natural antibody against antigens of the G (Gross) system, and apparently to the deposition in the glomeruli of immune complexes of G natural antibody with G soluble antigen (GSA), type-specific antigen specified by wild-type Gross leukemia virus. G natural antibody and GSA are detectable in the acid-buffer eluate of the kidneys of NZB mice during the course of the glomerulonephritis. (NZB x NZW) F(1) hybrid mice develop glomerulonephritis and produce GSA and free G natural antibody earlier in life than do NZB mice. The proteinuria manifestation of the gomerulonephritis of (NZB x NZW) F(1) hybrid mice becomes increasingly prevalent as GSA undergoes immune elimination from the circulation. Gross leukemia virus-specified antigens together with bound immunoglobulins are located in the glomerular lesions of (NZB x NZW) F(1) hybrid mice, both in the mesangium as observed in NZB mice and also in the wall of the peripheral capillary loops of the glomeruli.
Scintigraphic assessment of SO dysfunction
Authors: E Corazziari, M Cicala, F Scopinaro, O Schillaci, I F Habib, N Pallotta
Journal: Gut (2003)

As diagnosis of sphincter of Oddi (SO) dysfunction may require perendoscopic manometric assessment of the sphincter, which is an invasive technique carrying a significant risk of pancreatitis, non-invasive scintigraphy has been proposed as an alternative diagnostic method. Craig et al (Gut 2003; 52 :352–7) reported their experience in assessing SO dysfunction in post-cholecystectomy patients with scintigraphy using the hepatic hilum-duodenum transit time (HHDT) of Cicala and colleagues1 and the scoring system of Sostre and colleagues.2 In the study of Craig et al , scintigraphic data after cholecystokinin octapeptide (CCK-OP) infusion were compared with SO basal pressure, the latter recorded at manometry in the absence of any stimulus.

Craig et al concluded that none of the above scintigraphic variables was sufficiently sensitive to diagnose SO dysfunction identified at SO manometry. Although it is evident that the scintigraphic method of Craig et al used in their study was indeed poorly sensitive, the conclusion of their study cannot be extended to interpret the validity of scintigraphy, as performed in other centres.

It is …
MutS Homologue 2 and the Long-term Benefit of Adjuvant Chemotherapy in Lung Cancer
Authors: Nermine S. Kamal, Jean-Charles Soria, Jean Mendiboure, David Planchard, Ken A. Olaussen, Vanessa Rousseau, Helmut Popper, Robert Pirker, Pascale Bertrand, Ariane Dunant, Thierry Le Chevalier, Martin Filipits, Pierre Fouret
Journal: Clinical Cancer Research (2010)

We sought to determine the long-term (median follow-up, 7.5 years) predictive power of human MutS homologue 2 (MSH2) immunohistochemical expression in patients who enrolled in the International Adjuvant Lung Trial.We tested the interaction between MSH2 and the allocated treatment (chemotherapy versus observation) in a Cox model adjusted on clinicopathologic variables. The significance level was set at 0.01.MSH2 levels were low in 257 (38%) and high in 416 (62%) tumors. The benefit from chemotherapy was likely different according to MSH2 (interaction test, P = 0.06): there was a trend for chemotherapy to prolong overall survival when MSH2 was low [hazard ratio (HR), 0.76; 95% confidence interval (95% CI), 0.59-0.97; P = 0.03], but not when MSH2 was high (HR, 1.12; 95% CI, 0.81-1.55; P = 0.48). In the control arm, the HR was 0.66 (95% CI, 0.49-0.90; P = 0.01) when MSH2 was high. When combining MSH2 with excision repair cross-complementing group 1 (ERCC1) into four subgroups, the benefit of chemotherapy decreased with the number of markers expressed at high levels (P = 0.01). A similar decrease was noted when combining MSH2 and P27 (P = 0.01). Chemotherapy prolonged overall survival in the combined low MSH2/low ERCC1 subgroup (HR, 0.65; 95% CI, 0.47-0.91; P = 0.01) and in the combined low MSH2/low P27 subgroup (HR, 0.65; 95% CI, 0.46-0.93; P = 0.01).MSH2 expression is a borderline significant predictor of a long-term benefit from adjuvant cisplatin-based chemotherapy in patients with completely resected lung cancer. MSH2 combined with ERCC1 or P27 may identify patients most likely to benefit durably from chemotherapy.
TCT-213 Prospective estimation of Chronic Total Occlusion complexity based on Clinical and Anatomic (Invasive and non-invasive Angiography) characteristics
Authors: Beatriz Vaquerizo, Antonio Barros, Ester Bajo, DARLENE ESTRADA-YÁNEZ, Faustino Miranda-Guardiola, Marcelo Jimenez Kockar, Juan Cinca, Antonio Serra
Journal: Journal of the American College of Cardiology (2014)
Cardiazol Therapy in Stupor
Authors: J. S. Harris, C. R. Birnie
Journal: BMJ (1938)

The treatment of schizophrenia by cardiazol has been practised on the Continent to an increasing extent in recent years, and the view is current that a favourable response is often met with in cases of stupor.In the present series eighteen cases of stupor were treated, and in their selection no special criteria were employed.Each case, however, was carefully examined to exclude organic disease.The stupor, although it varied in depth, was the outstanding clinical feature in each case.
Using the Physician Global Assessment in a Clinical Setting to Measure and Track Patient Outcomes
Authors: Vanessa L. Pascoe, Monica Enamandram, Kristen C. Corey, Carol E. Cheng, Emilia J. Javorsky, Sarah M. Sung, Kevin R. Donahue, Alexandra B. Kimball
Journal: JAMA Dermatology (2014)

In dermatology, the development of objective, standardized quality measures that can be used in a clinical setting is important to be able to respond to the needs of payers and credentialing and licensure bodies and to demonstrate dermatologic value.OBJECTIVE To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and psoriasis outcomes over time. DESIGN, SETTING, AND PARTICIPANTSThe PGA severity scores were included on physicians' billing sheets for patients with acne and psoriasis seen at a tertiary care center outpatient dermatology clinic from June 2011 through October 2012.A subset of patients from 5 clinics completed Patient Global Assessments (PtGAs) between November 2011 and May 2012.Thirty dermatology clinicians saw a total of 2770 patients with acne and 1516 patients with psoriasis in clinic, recording PGA scores for each patient.The PtGA scores were collected from 52 and 103 patients with acne and psoriasis, respectively, within the larger sample. MAIN OUTCOMES AND MEASURESLongitudinal PGA severity scores were collected for acne and psoriasis.The PGA severity scores were analyzed over time, with the hypothesis that patient scores for both acne and psoriasis would improve between the initial and follow-up visits.The PtGA scores from a subset of clinics and dates were compared with PGA scores to assess within-clinic reliability, with the hypothesis that there would be good agreement between clinician and patient assessments.RESULTS New patient PGA outcomes showed considerable improvement over time.At 3-month follow-up, 14.6% of the acne cohort was graded as effectively clear, compared with 2.1% at baseline (P < .001).Similarly, at 3-month follow-up, 22.3% of the psoriasis cohort was graded as effectively clear, compared with 3.1% at baseline (P < .001).Additionally, interobserver agreement between PGA and PtGA scores was good (acne, κ = 0.68; psoriasis, κ = 0.70). CONCLUSIONS AND RELEVANCEThe PGA can be readily incorporated into practice to track patient acne and psoriasis outcomes over time, representing an opportunity for dermatologists to evaluate performance and validate practice guidelines.
P551 EVALUATION OF ART SCORE FOR REPEATED TRANSARTERIAL CHEMOEMBOLIZATION IN JAPANESE COHORT OF HEPATOCELLULAR CARCINOMA
Authors: T. Arizumi, K. Ueshima, H. Chishina, M. Takita, S. Kitai, T. Inoue, N. Yada, S. Hagiwara, Y. Minami, T. Sakurai, N. Nishida, M. Kudo
Journal: Journal of Hepatology (2014)
Double-cuff endotracheal tube.
Authors: P D Salpekar
Journal: BMJ (1971)

S52pamide or tolbutamide), the output of glucose from the liver is reduced.The hyperglycaemic response to glucagon is usually satisfactory, though glucagon also stimulates the secretion of insulin.In all cases of hypoglycaemia, once consciousness is regained, adequate carbohydrate must be given by mouth to prevent the development of secondary hypoglycaemia.Any precipitating factor should be excluded and the patient's diet and dose of hypoglycaemic drug should be carefully considered.
DEVELOPMENTS IN THE PROBLEM OF ARTHRITIS
Authors: RALPH PEMBERTON
Journal: JAMA (1931)

Neglected for many years, the problem of arthritis has been kept alive in the medical mind largely through the solicitude of orthopedic surgeons. Itself the legitimate child of internal medicine, it has been reared by others acting as foster parents to it. Having come of age, arthritis is at last being recognized and gathered unto the bosom of the medical family. It is a gratifying spectacle to those interested in the rheumatoid problem to see that it is taking its place as one of the great chapters of medicine, along with tuberculosis and syphilis. Ten years ago there were perhaps two or at most three clinics for the study of arthritis. Today there are such clinics in nearly every medical center and, in some cities, several. The reasons for this development have been pressure from the industrial world to reduce disability pensions, especially in Europe; the natural internal growth of
Endoscopic Assessment in Abetalipoproteinemia (Bassen-Kornzweig-Syndrome)
Authors: G. Delpre, U. Kadish, I. Glantz, I. Avidor
Journal: Endoscopy (1978)

Die bei einem 26jährigen Patienten mit Bassen-Kornzweig-Syndrom beobachteten Schleimhautveränderungen im Duodenum anläßlich einer endoskopischen Untersuchung werden vorgestellt.
Association of Institutional Financial Support of a Core Teaching Faculty With Educational Productivity
Authors: Michael T. Fitch, Hal H. Atkinson, Cynthia A. Burns, M. Ann Lambros
Journal: JAMA (2010)

Comment.US MD seniors filled 65.7% of available PGY-1 positions in the 2010 NRMP match, but 95.4% of the positions were filled, the difference consisting primarily of graduates of osteopathic medical schools, US citizen graduates of international medical schools, and non-US citizen graduates of international medical schools. 2 The percentage of US MD seniors failing to match through the NRMP has remained stable at 6% to 7% during the past 5 years. 2 However, the number of unfilled PGY-1 positions after the match has decreased from 1587 in 2006 to 1060 in 2010. 2 Study limitations include an inability to confirm the accuracy of the deans' reports and opinions.Nevertheless, this survey indicates that a significant number of seniors may fail to realistically assess their competitiveness for postgraduate positions in the most highly sought fields or fail to rank programs in less competitive specialties.With the number of positions after the NRMP match decreasing, efforts must be made to appropriately counsel senior medical students on their training options.