Hypophosphatemia Complicating Management of Acute Severe Asthma
Authors: Jean-Pierre Laaban
Journal: Annals of Internal Medicine (1990)

Brief Reports1 January 1990Hypophosphatemia Complicating Management of Acute Severe AsthmaJean-Pierre Laaban, MD, Myrna Waked, MD, Muriel Laromiguiere, PharmD, Tu-Khanh Vuong, MD, Jacques Rochemaure, MDJean-Pierre Laaban, MDSearch for more papers by this author, Myrna Waked, MDSearch for more papers by this author, Muriel Laromiguiere, PharmDSearch for more papers by this author, Tu-Khanh Vuong, MDSearch for more papers by this author, Jacques Rochemaure, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-1-68 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe correction of acute respiratory acidosis by mechanical ventilation in patients with chronic obstructive pulmonary disease has been shown to induce hypophosphatemia (1-3). In patients with acute respiratory failure, hypophosphatemia may have harmful effects because it may decrease diaphragmatic contractility (4) and impair tissue oxygenation by causing a decrease in the erythrocyte 2,3-diphosphoglycerate concentration (5). However, the variations in serum phosphorus levels have not been studied in other settings of acute respiratory acidosis. We aimed to determine whether hypophosphatemia may develop during the treatment of acute severe asthma.Patients and MethodsWe did a prospective study of 18 consecutive patients...References1. Storm T. Severe hypophosphataemia during recovery from acute respiratory acidosis. Br Med J [Clin Res]. 1984;289:456-7. CrossrefMedlineGoogle Scholar2. Squara P, Bleichner G, Aubier M, Parent A, Sollet J, and Murciano D. Hypophosphoraemia during mechanical ventilation for chronic obstructive pulmonary disease. Presse Med. 1985;14:1225-8. MedlineGoogle Scholar3. Laaban J, Grateau G, Psychoyos I, Laromiguière M, Vuong T, and Rochemaure J. Hypophosphatemia induced by mechanical ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med. 1989;[In press]. CrossrefMedlineGoogle Scholar4. Aubier M, Murciano D, and Lecocguic Y. Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. N Engl J Med. 1985;313:420-4. CrossrefMedlineGoogle Scholar5. Knochel J. Deranged phosphorus metabolism. In:Seldin DW, Giebisch G, eds. The Kidney: Physiology and Pathophysiology. New York:Raven Press;1985:1397-416. Google Scholar6. Mostellar M and Tuttle E. Effects of alkalosis on plasma concentration and urinary excretion of inorganic phosphate in man. J Clin Invest. 1964;43:138-49. CrossrefMedlineGoogle Scholar7. Guntupalli J, Matthews B, Carlin B, and Bourke E. Effect of acute hypercapnia on PTH-stimulated phosphaturia in dietary Pi-deprived rat. Am J Physiol. 1987;253:F34-40. MedlineGoogle Scholar8. Colin A, Kraiem Z, Kahana L, and Hochberg Z. Effects of theophylline on urinary excretion of cyclic AMP, calcium, and phosphorus in normal subjects. Miner Electrolyte Metab. 1984;10:359-61. MedlineGoogle Scholar9. Body J, Cryer P, Offord K, and Heath H. Epinephrine is a hypophosphatemic hormone in man. Physiological effects of circulating epinephrine on plasma calcium, magnesium, phosphorus, parathyroid hormone, and calcitonin. J Clin Invest. 1983;71:572-8. CrossrefMedlineGoogle Scholar10. Montanari A, Borghi L, and Curti A. Skeletal muscle cell abnormalities in acute hypophosphatemia during total parenteral nutrition. Miner Electrolyte Metab. 1984;10:52-7. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Jean-Pierre Laaban, MD; Myrna Waked, MD; Muriel Laromiguiere, PharmD; Tu-Khanh Vuong, MD; Jacques Rochemaure, MDFrom Hôtel-Dieu de Paris, Paris, France. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisorders of Calcium, Magnesium, and Phosphate BalanceA Synopsis of Phosphate Disorders in the Nursing HomeElectrolyte DisturbancesIatrogenic-induced dysfunction of the neuromuscular respiratory systemMedical and ventilatory management of status asthmaticusIntravenous phosphate repletion regimen for critically ill patients with moderate hypophosphatemiaHypophosphatemia and Hyperphosphatemia 1 January 1990Volume 112, Issue 1Page: 68-69KeywordsAsthmaAttentionBiochemistryChronic obstructive pulmonary diseasePhosphorusProspective studiesRespiratory failureToxicologyVentilators ePublished: 1 December 2008 Issue Published: 1 January 1990 PDF downloadLoading ...