tbuckley/cabot-search huggingface dataset:
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
Authors: Chiea Chuen Khor, Sonia Davila, Willemijn B. Breunis, Yi Ching Lee, Chisato Shimizu, Victoria J. Wright, Rae S.M. Yeung, Dennis E.K. Tan, Kar Seng Sim, Jie Jin Wang, Tien Yin Wong, Junxiong Pang, Paul Mitchell, Rolando Cimaz, Nagib Dahdah, Yiu Fai Cheung, Guo Ying Huang, Wanling Yang, In Sook Park, Jong Keuk Lee, Jer Yuarn Wu, Michael Levin, Jane C. Burns, David Burgner, Taco W. Kuijpers, Martin L. Hibberd, Yu Lung Lau, Jing Zhang, Xiao Jing Ma, Fang Liu, Lin Wu, Jeong Jin Yoo, Soo Jong Hong, Kwi Joo Kim, Jae Jung Kim, Young Mi Park, Young Mi Hong, Sejung Sohn, Gi Young Jang, Kee Soo Ha, Hyo Kyoung Nam, Jung Hye Byeon, Sin Weon Yun, Myung Ki Han, Kyung Yil Lee, Ja Young Hwang, Jung Woo Rhim, Min Seob Song, Hyoung Doo Lee, Dong Soo Kim, Jae Moo Lee, Jeng Sheng Chang, Fuu Jen Tsai, Chi Di Liang, Ming Ren Chen, Hsin Chi, Nan Chang Chiu, Fu Yuan Huang, Luan Yin Chang, Li Min Huang, Ho Chang Kuo, Kao Pin Huang, Meng Luen Lee, Betau Hwang, Yhu Chering Huang, Pi Chang Lee, Miranda Odam, Frank T. Christiansen, Campbell Witt, Paul Goldwater, Nigel Curtis, Pamela Palasanthiran, John Ziegler, Michael Nissen, Clare Nourse, Irene M. Kuipers, Jaap J. Ottenkamp, Judy Geissler, Maarten Biezeveld, Carline Tacke, Luc Filippini, Paul Brogan, Nigel Klein, Vanita Shah, Michael Dillon, Robert Booy, Delane Shingadia, Anu Bose, Thomas Mukasa, Robert Tulloh, Colin Michie, Jane W. Newburger, Annette L. Baker, Anne H. Rowley, Stanford T. Shulman, Wilbert Mason, Masato Takahashi, Marian E. Melish, Adriana H. Tremoulet, Ananth Viswanathan, Elena Rochtchina, John Attia, Rodney Scott, Elizabeth Holliday, Stephen Harrap
Journal: Nature Genetics (2011)
Copper and Cancer
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.
Authors: P C Doherty, J C Bennink
Journal: The Journal of Experimental Medicine (1979)

BALB/c (H-2Kd-Dd) spleen and lymph node populations were specifically depleted of alloreactive potential by filtration through H-2 different, irradiated recipients. These negatively selected T cells were then stimulated with vaccinia virus in mice expressing the foreign H-2 determinants encountered previously in the filter environment. Strong virus-immune cytotoxic T-cell responses were seen in the context of H-2Kk and H-2Ks, but not 2H-2Kb. The T cells generated were not cross-reactive for the H-2Kk and H-2Kd alleles, and responsiveness was independent of concurrent presence of effector populations operating at H-2D. These findings are consisent with the idea that recognition is mediated via a complex receptor, part of which is specific for virus and part for self H-2. The capacity to interact with allogeneic, virus-infected cells may then reflect aberrant recognition of a virus-H-2-antigen complex by this single, large binding site. For instance, the T cell which would normally recognize H-2Kd-virus x, or H-2Dd-minor histocompatibility antigen Z, may now show specificity for H-2Kk-vaccinia virus. Implications for both the selective role of the thymus and for mechanisms of tolerance are discussed.
Hollander Test Unnecessary
Authors: Lester R. Dragstedt
Journal: JAMA (1970)

ABSTRACT To the Editor.— I have just read with much interest and some concern the article entitled  Test May Cause Dangerous Arrhythmia which appeared in Medical News (210:2005,1969). Since I introduced the operation of vagotomy in the treatment of peptic ulcer, I am naturally concerned with all aspects of this operation. I believe that the Hollander test should be abandoned except perhaps in a few patients where it is desirable to determine if a previous vagotomy has been complete or not. In almost all cases a measurement of the basal or fasting gastric secretion is a more useful and accurate procedure. In the patient with a duodenal ulcer, the secretion of acid by the fasting empty stomach is usually three to five times normal. If the basal secretion has not been reduced by vagotomy, the cause is usually the presence of an undiagnosed Ellison-Zollinger tumor or to failure to
Use of Drugs in Asphyxia
Authors: W. N. Leak
Journal: BMJ (1947)

exertion such as digging or rpowing a rough lawn with an old lawn-mower.The abdominal wall felt icy to the touch, and aftersuch exertion I would have an acute attack as described.It could not be put down to icy water as we had no refrigerator and usually the water remained tepid after boiling.Stools were negative.Apart from these acute attacks I normally had three or four loose stools daily during the hot weather.I eventually found that a " belly pad " consisting of about a square foot of woollen vest, lined on the inside with an old piece of " lock-knit " cotton material, tied round the neck and waist, was almost specific.The Chinese (Hakka) people dress their small children in a "belly pad " in the hot weather.-Iam, etc., Leyburm, Yorks.
Zur Casuistik der periodisch verlaufenden Geistesstörungen von Dr. Georg Eisath, Hilfarzt der Landes-Irrenanstalt Hall-Tirol. Allgemeine Zeitschrift für Psychiatric. Sechzigster Band Drittes Heft. (May 20, 1903.)
Authors: W. McD.
Journal: American Journal of Psychiatry (1904)
On the Treatment of Certain Forms of Cerebral Paralysis by the Continuous Galvanic Current
Authors: J. Althaus
Journal: BMJ (1870)

Aptril 23, I870.tion.It has been ascribed to spasmodic action likewise.The occur- rence of it at a very early stage would afford good grounds for this sup- position.As the pain is the symptom which causes most distress, erection of the organ may to some extent be prevented by the internal use of bromide of potassium, opium, and camphor, and the local, as well as internal, use of belladonna, cold bathing, etc. Epididymitis, or swelled testicle, is seldom met with save in chronic cases, or where violent injections have been used during the acute stage.In the acute stage of epididymitis, relief is obtained from leeching, hot fomentations, and the exhibition of calomel and opium.In the chronic, the adminis- tration of the bichloride of mercury and local blistering afford the best results.This condition is essentially due to an extension of the ure- thral inflammation by contiguity of surface.One important compli- cation of swelled testicle is inflammation of the cord.Not unfre- qnently the vas deferens is felt like a quill under the finger.As this condition, if unattended to, may occlude the vas deferens, and, if on both sides, thus cause sterility, it claims particular attention.On the part of intelligent patients it gives rise to considerable uneasiness.Gonorrhbea in the female is amenable to the same treatment, the beneficial results from balsamics excepted.The tincture of the muriate of iron will, however, be found equally valuable in vaginal gonorrhcea.In the preventive treatment of gonorrhcea, cleanliness is of primary import- ance; and I incline most decidedly to the belief that, when any suspi- cion of the disease exists, its course may be checked by the timeous use of astringent or caustic injections, While the disease afflicts hu- manity, and not unfrequently proves a casus beZli in the family circle, it is ours to study the best methods of cure, and the meanest disease of the human body is alike the care of the moralist and the philanthropist.
The Southall Diabetes Survey: prevalence of known diabetes in Asians and Europeans.
Authors: H M Mather, H Keen
Journal: BMJ (1985)

A house to house inquiry for patients with known diabetes was carried out in a defined area of Southall, west London, which contained over 34 000 Asians and 27 000 Europeans in the 1981 Census: 1143 diabetic patients were ascertained, of whom 761 were Asian and 324 European. The prevalence adjusted for age of known diabetes in Asians was at least 3.8 times higher than that in Europeans. For patients aged between 40 and 64 years it was at least five times higher, was over 12% in Asians aged 60-69, and over 8% in those aged 50-59. These data are important in planning for the care of diabetic patients in health districts with large Asian communities. The causes and later consequences of this exceptionally high prevalence require further study.
Abstract 1049: Noninvasive Detection of Macrophage-dense Atherosclerotic Plaque in Hyperlipidemic Rabbits using ‘Positive Contrast’ Magnetic Resonance Imaging.
Authors: Grigorios Korosoglou, Robert G Weiss, Dorota A Kedziorek, Piotr Walczak, Wesley D Gilson, Michael Schar, David Sosnovik, Dara L Kraitchman, Jeff W Bulte, Ralph Weissleder, Matthias Stuber
Journal: Circulation (2007)

Purpose: To identify macrophage-dense atherosclerotic plaques after the systemic administration of superparamagnetic nanoparticles with magnetic resonance imaging (MRI) using a positive contrast of...
Familial Risks for Type 2 Diabetes in Sweden
Authors: Kari Hemminki, Xinjun Li, Kristina Sundquist, Jan Sundquist
Journal: Diabetes Care (2009)

OBJECTIVE Our aim was to characterize familial risks for type 2 diabetes by the type and number of affected family members, including half-siblings, adoptees, and spouses, to quantify risks and estimate the contribution of environmental effect. RESEARCH DESIGN AND METHODS Families were identified from the Multigeneration Register, and type 2 diabetic patients were obtained from the Hospital Discharge Register. Standardized incidence ratios were calculated for offspring with type 2 diabetes whose family members were hospitalized for type 2 diabetes at ages &amp;gt;39 years compared with those lacking affected family members. RESULTS The number of hospitalized type 2 diabetic patients was 157,549. Among 27,895 offspring, 27.9% had a parent or sibling also hospitalized for type 2 diabetes. The familial relative risk (RR) ranged from 2.0 to &amp;gt;30, depending on the number and type of probands. The highest RRs of type 2 diabetes were found in individuals who had at least two siblings affected by type 2 diabetes, irrespective of the parental disease. Adoptees showed no risk from adopted parents. CONCLUSIONS The study, the largest yet published, showed that familial RRs varied by the number and type of affected family member. However, much of the familial clustering remains yet to be genetically explained. The high risk should be recognized in clinical genetic counseling. The data from adoptees confirmed the genetic basis of the familial associations, but those from half siblings and spouses suggested that a smaller part of familial clustering may be accounted for by environmental factors.
Obesity rates dip slightly among some poor children in the US
Authors: M. McCarthy
Journal: BMJ (2013)

After rising steadily for decades, obesity rates among poor preschool children in the United States have dipped or held steady in 19 states and territories, says a report from the US Centers for Disease Control and Prevention (CDC). 

Health officials hailed the findings as a sign that the US may finally be making some progress in its battle against childhood obesity. Tom Frieden, the CDC’s director, said, “Although obesity remains epidemic, the tide has begun to turn for some kids in some states.”

The study, which is reported …
Recurrent urinary tract infection in women
Authors: J. Car
Journal: BMJ (2003)

A 23 year old female student complains of urinary frequency and pain on micturition. She has had similar episodes on four other occasions in the last six months. She wants to know what can be done now and how to prevent further infections.

Is it really a urinary tract infection? Differential diagnoses include common genital infections (such as sexually transmitted infections and Candida vulvovaginitis), non-infective cystitis (caused by nonsteroidal anti-inflammatory drugs and other drugs), and urethral syndrome (a complex of symptoms that indicate a urinary tract infection but without an underlying infection).

Type of urinary tract infection Symptoms that indicate a lower urinary tract infection are discomfort on urination, increased frequency of urination, urgency, and a change in the smell of the urine. Symptoms that indicate an upper urinary tract infection are a high temperature, pain in …
DIETARY ISOFLAVONE INTAKE IS ASSOCIATED WITH LOWER SYSTOLIC BLOOD PRESSURE: THE CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY
Authors: Safiya Richardson, Che Smith, Lora Burke, Zhou Xia, James M. Shikany, Lyn Steffen, Carlos Jose Rodriguez
Journal: Journal of the American College of Cardiology (2012)
Abstract 1422: Validation of primary non-small cell lung cancer model: Stable isotope-resolved metabolomics (SIRM) reveals functional biochemistry
Authors: Connor J. Kinslow, Teresa W-M Fan, Jin L. Tan, Pawel K. Lorkiewicz, Ramya Balasubramaniam, Yihua Cai, Jun Yan, Andrew N. Lane
Journal: Cancer Research (2014)

Abstract Stable isotope-resolved metabolomics (SIRM) provides a comprehensive and functional readout of cellular activity and is therefore a useful tool both for biomarker discovery and fundamental cancer biology. We have established a primary lung squamous cell carcinoma line (PSLC1), isolated from the lung tumor tissue of a non-small cell lung cancer patient, for which the metabolic profile has been established. We used SIRM to characterize the metabolic activity of the cells in mouse xenografts and in cell culture. Here we report the metabolic activities of the cell line in culture using two different tracers to evaluate central metabolism. PSLC1 cells were grown in either [U-13C]-glucose or [U-13C,15N]-glutamine labeled medium. Cell extracts and medium were prepared and analyzed by 1H-NMR, HSQC, TOCSY, GC-MS, and FTICR-MS. Cells exhibited linear glucose consumption that persisted even as proliferation plateaued. The conversion of glucose to lactate occurred at a strikingly high 89%. Anaplerotic pathways involving pyruvate carboxylation and glutaminolysis were active and appeared to be dependent on cellular proliferation. Glutamine represented an important contributor for biosynthetic and bioenergetic cellular needs, including de novo pyrimidine biosynthesis and glucose-independent TCA cycling. In addition, glutamine served as the major precursor in proline and glutathione biosynthesis. Distinct glutamine utilization and labeling patterns indicated that this cancer might be driven by C-MYC overexpression. C-MYC overexpression was observed by targeted protein analysis guided by metabolomics-edited transcriptomics analysis (Pro-META). The ability of SIRM to generate hypotheses about protein expression demonstrates its potential use as a first line biomarker detection method. Comparison with upstream in situ and xenograft data will allow us to assess model validity and the effects of tumor microenvironment. In turn, the in vitro data will help us interpret human in situ data more robustly. Supported by grant R25-CA-134283 and 1P01CA163223-01A1 from the National Cancer Institute Citation Format: Connor J. Kinslow, Teresa W-M Fan, Jin L. Tan, Pawel K. Lorkiewicz, Ramya Balasubramaniam, Yihua Cai, Jun Yan, Andrew N. Lane. Validation of primary non-small cell lung cancer model: Stable isotope-resolved metabolomics (SIRM) reveals functional biochemistry. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1422. doi:10.1158/1538-7445.AM2014-1422
Total knee replacement: the joint of the decade
Authors: C G Moran
Journal: BMJ (2000)

Hip replacements were developed in the 1960s and within a decade had revolutionised the treatment of hip arthritis in elderly patients. This success heightened interest in other joints, particularly the knee. With no constraint on the development and use of surgical implants there was a short period of divergent evolution, and a great variety of knee replacements were produced. Natural selection soon occurred and many designs failed rapidly—hinged knees caused particular problems. Thus, in the 1970s and early 1980s knee replacement was widely considered to be a poor operation. Some designs were successful, however: these attempt to resurface the joint and reproduce normal knee anatomy with a low friction joint. The remaining knee ligaments provide stability, allowing some rotational movement and good function. Total knee replacements have subsequently undergone a period of convergent evolution, and most implants …
Repolarization abnormalities in heart failure
Authors: R Coronel
Journal: Cardiovascular Research (2002)

See article by Lacroix et al. [1] (pages 42–50) in this issue. 

The paper by Lacroix et al., published in this issue of Cardiovascular Research, is of interest because it deals with the question of mechanisms underlying sudden arrhythmic death in patients with heart failure [1]. This is a problem of great clinical significance, because increasing numbers of patients are suffering from heart failure and are at risk of sudden cardiac death [2], especially at moderate degrees of failure [3].

Heart failure is extremely difficult to study experimentally, not only because it is difficult to define [4], but also because a single suitable experimental model is not available. Several models relevant for the study of arrhythmogenesis in heart failure exist [5–8], but since heart failure in man results from a plethora of conditions, none of these models can withstand criticism regarding its clinical significance. In addition, the development of experimental models is costly as it involves the study of animals over prolonged periods of time. Another complicating factor is that, if the model is truly representative, a high percentage of the animals will die suddenly before they can be studied.

In the majority of cases, sudden death in heart failure is caused by sustained ventricular tachyarrhythmias [9]. For … 

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The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance?
Authors: L.‐G. Hersoug, A. Linneberg
Journal: Allergy (2007)

There is increasing epidemiological evidence that obesity increases the risk of asthma, atopic, and autoimmune diseases. We hypothesize that the increase in these diseases is caused, at least in part, by decreased immunological tolerance as a consequence of immunological changes induced by adipokines (e.g. leptin and adiponectin) and cytokines [e.g. interleukin 6 (IL6) and tumor necrosis factor alpha (TNFalpha)] secreted by white adipose tissue. The increasing body weight increases the levels of circulating IL6, leptin, and TNFalpha. IL6 and leptin down-regulate the activity of regulatory T-lymphocytes (Tregs). Additionally, adiponectin, which decreases with increasing obesity, down-regulates the secretion of IL10 from macrophages and adipocytes. These changes in IL6, leptin, and IL10 decrease the regulatory effect of Tregs resulting in decreased immunological tolerance to antigens. In pregnant women, these obesity-induced immunological changes might be transmitted to the fetus by epigenetic inheritance thereby increasing the risk of atopic disease. We propose that obesity results in immunological changes resulting in decreased immunological tolerance to antigens and skewing of the immune system towards a Th2 cytokine profile increasing the risk of allergy and other immune-mediated diseases. Furthermore, this hypothesis offers a unifying explanation for the observation that older siblings appear to confer protection against atopic diseases, preeclampsia, and certain autoimmune diseases. More studies are definitely needed to explore further the immunological effects of obesity and its possible effects on allergic disease.
Autoantibodies specific to a peptide of β2-glycoprotein I cross-react with TLR4, inducing a proinflammatory phenotype in endothelial cells and monocytes
Authors: Tania Colasanti, Cristiano Alessandri, Antonella Capozzi, Maurizio Sorice, Federica Delunardo, Agostina Longo, Marina Pierdominici, Fabrizio Conti, Simona Truglia, Alessandra Siracusano, Guido Valesini, Elena Ortona, Paola Margutti
Journal: Blood (2012)
Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer—Letter
Authors: Haifeng Qiu
Journal: Clinical Cancer Research (2014)

In a recent article, Cardnell and colleagues reported that BMN 673 (a novel PARP inhibitor) exhibited striking activities in small cell lung cancer (SCLC) cell lines and xenografts, and that cellular sensitivity to BMN 673 was associated with high baseline expression of several DNA repair proteins.