tbuckley/cabot-search huggingface dataset:
Merger of two hospital trusts is approved under new, faster approval process
Authors: G. Iacobucci
Journal: BMJ (2014)

Two NHS foundation hospital trusts are to become the first in England to merge, after a watchdog ruled that the move would not damage competition.

The Competition and Markets Authority this week cleared the plans for Frimley Park NHS Foundation Trust in Surrey to acquire neighbouring Heatherwood and Wexham Park NHS Foundation Trust, after examining evidence from the hospitals and from third parties.

The authority ruled that the proposed acquisition would not severely affect competition or patients’ choice and was the best available solution to the problems faced by Heatherwood and Wexham Park, which was recently placed in special measures after the healthcare regulator the Care Quality Commission reported inadequate care and weak leadership …
Abstract 3119: A synthetic lethal screen identifies genetic determinants for gemcitabine sensitivity in pancreatic cancer
Authors: Jerome C. Landry, Brooke G. Pantazides, Wungki Park, Joseph W. Shelton, Shishir K. Maithel, Bassel El-Rayes, David S. Yu
Journal: Cancer Research (2012)

Abstract Pancreatic cancer is notorious for its devastating disease course and prognosis. Gemcitabine is a widely used regimen for pancreatic cancer treatment but lack of response and resistance often limits its use. To identify the genes and mechanisms involved in determining gemcitabine sensitivity in pancreatic cancer, we completed a loss of function genetic screen using RNA interference to identify genes which when silenced are synthetically lethal with a low dose of gemcitabine in human pancreatic cancer cells. We optimized an assay using ATR or CHK1 siRNA as positive controls and ATM or non-targeting (NT) siRNA as negative controls. Our siRNA library included 4,474 siRNAs corresponding to 1,006 unique human genes arrayed in a one-gene:one-well format in 96-well plates. Genes chosen for our library consisted predominantly of nuclear enzymes, including but not limited to kinases, phosphatases, ubiquitinylation proteins, sumoylation proteins, acetylases, deactylases, nucleases, helicases, and chromatin modifiers, which we reasoned were more likely to function directly in DNA repair processes and be targetable. MIA PaCa-2 cells were transfected with 25 nM siRNA and treated 48 hours later with or without 13 nM gemcitabine for 72 hours prior to the cell proliferation assay using WST-1 reagent. Using this assay, we identified 87 genes which when silenced caused gemcitabine sensitization and 42 genes which when silenced caused gemcitabine resistance. Positive hits included 16 known genome maintenance genes including well-characterized ATR signaling pathway genes - CHK1, RAD9, HUS1, and CDC25A, 5 putative ATM/ATR substrates, and 20 genes identified in previously published DNA damage sensitivity screens. 21 of the genes are somatically mutated or differentially expressed in pancreatic cancer, suggesting that our gemcitabine sensitivity genes may function as useful predictive biomarkers or novel targets for the treatment of pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3119. doi:1538-7445.AM2012-3119
Photopenic to Avid Radiogallium Transition after Rupture of the Marrow Cavity in Acute Femoral Osteomyelitis
Authors: JOHN J. SZIKLAS, RONALD J. ROSENBERG, RONALD E. WEINER, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1992)

A 4-year-old boy had markedly reduced Ga-67 uptake in a painful left leg when compared with the right. A repeat study 9 days later showed an intense accumulation of nuclide in the lower left femur and surrounding area. Increased intramedullary pressure probably precluded Initial Ga-67 delivery into the site of infection, and subsequent release of this pressure permitted accumulation.
Dialysis and Psoriasis
Authors: HELMUT GRAF
Journal: Annals of Internal Medicine (1979)

Letters and Correction1 June 1979Dialysis and PsoriasisHELMUT GRAF, M.D., AXEL WOLF, M.D., HANS KRISTER STUMMVOLL, M.D.HELMUT GRAF, M.D.Search for more papers by this author, AXEL WOLF, M.D.Search for more papers by this author, HANS KRISTER STUMMVOLL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-994_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Since the amelioration of psoriasis during dialysis was first described (1), a number of reports of positive effects of dialysis on this troublesome and often therapy-resistant disease have been published (2-7). At present, peritoneal dialysis (5, 6) and hemodialysis (5, 7) are used as therapy in otherwise untreatable cases. To our knowledge there has been no previous report of a psoriatic patient with renal insufficiency in whom chronic hemodialysis showed no positive effect in psoriasis.A 32-year-old man had first had psoriasis vulgaris 14 years previously. Ten years after onset of this disease, albuminuria was discovered, and...References1. MCEVOY J and KELLY A: Psoriatic clearance during hemodialysis. Ulster Med J 45:76-78, 1976 MedlineGoogle Scholar2. TWARDOWSKI Z: Abatement of psoriasis and repeated dialysis (letter). Ann Intern Med 86:509-510, 1977 LinkGoogle Scholar3. MUSTON H and CONCEICAO S: Remission of psoriasis during haemodialysis. Br Med J 1:480-481, 1978 CrossrefMedlineGoogle Scholar4. SON B and BAGUIO M: Dialysis and psoriasis (letter). Ann Intern Med 88:842, 1978 LinkGoogle Scholar5. BUSELMEIER T, KJELLSTRAND C, DAHL M, BURGDORF W, SIMMONS R, NAJARIAN J, and GOLTZ R: Treatment of psoriasis with dialysis (abstract) EDTA 15:10, 1978 Google Scholar6. TWARDOWSKI Z, NOLPH K, RUBIN J, and ANDERSON P: Peritoneal dialysis for psoriasis. An uncontrolled study. Ann Intern Med 88:349-351, 1978 LinkGoogle Scholar7. CHUGH K, NATH I, BEDI T, and PAREEK S: Dialysis and psoriasis (letter). Ann Intern Med 88:842-843, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HELMUT GRAF, M.D.; AXEL WOLF, M.D.; HANS KRISTER STUMMVOLL, M.D.Affiliations: Second Medical Department University of Vienna Vienna, Austria PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPsoriasisPlasmapheresis in the management of psoriasisDialysis and Haemofiltration for Non-Renal ConditionsHemofiltration treatment of psoriasis 1 June 1979Volume 90, Issue 6Page: 994-995KeywordsMedical dialysisPeritoneal dialysisPsoriasis ePublished: 1 December 2008 Issue Published: 1 June 1979 PDF downloadLoading ...
ARE CONSERVATIVE AMPUTATIONS ALWAYS IN THE BEST INTERESTS OF THE PATIENT?Read before the Mississippi Valley Medical Association, St. Louis, Mo., October 16, 1891.
Authors: CHARLES TRUAX
Journal: JAMA (1891)

In pre aseptic days, amputations were properly governed by an inflexible rule which taught that the first duty of the surgeon was to save every possible ounce of tissue, because, first, experience had demonstrated that the nearer the point of amputation approached the trunk and the broader the stump, the greater the risk of life; second, it was generally believed that in all cases the usefulness of a stump increased with its length. These principles, still taught in all of our standard text-books (save one) and having been practiced by every eminent operator from the first records of surgery down to the days of asepsis, are in general use to day—although the conditions forming the basis for their advocacy no longer exist, at least in their former weight and importance. The first of these principles was formulated at a time when pyæmia, septicæmia, or like complication endangered the life of
Science at the Bedside: Clinical Research in American Medicine, 1905-1945
Authors: William R. Barclay
Journal: JAMA (1982)

The exponential growth in scientific knowledge and technology since the end of World War II has brought about enormous changes in the practice of medicine. These advances could have been made, however, only if a new philosophy of medicine that brought science to the bedside had been developed in the first half of the 20th century. A. McGehee Harvey, one of the major contributors to the advances of 20th-century medicine, describes the trends, the institutions, and the people that laid the groundwork for advancing the United States into its leadership position in medical science in this unusual but rather disappointing book on the history of medicine in America between the turn of the century and the end of World War II. The book consists of four parts, four appendices, and an excellent collection of notes and references. Part 1 deals with formative influences in the 19th century that were largely
Physician Procedure Volume and Complications of Cardioverter-Defibrillator Implantation
Authors: James V. Freeman, Yongfei Wang, Jeptha P. Curtis, Paul A. Heidenreich, Mark A. Hlatky
Journal: Circulation (2011)

The outcomes of procedures are often better when they are performed by more experienced physicians. We assessed whether the rate of complications after implantable cardioverter-defibrillator (ICD) placement varied with the volume of procedures a physician performed.We studied 356 515 initial ICD implantations in the National Cardiovascular Data Registry-ICD Registry, performed by 4011 physicians in 1463 hospitals. We examined the relationship between physician annual ICD implantation volume and in-hospital complications, using hierarchical logistic regression to adjust for patient characteristics, implanting physician certification, hospital characteristics, hospital annual procedure volume, and the clustering of patients within hospitals and by physician. We repeated this analysis for ICD subtypes: single chamber, dual chamber, and biventricular. There were 10 994 patients (3.1%) with a complication after ICD implantation, and 1375 died (0.39%). The complication rate decreased with increasing physician procedure volume from 4.6% in the lowest quartile to 2.9% in the highest quartile (P<0.0001), and the mortality rate decreased from 0.72% to 0.36% (P<0.0001). The inverse relationship between physician procedure volume and complications remained significant after adjusting for patient, physician, and hospital characteristics (OR 1.55 for complications in lowest-volume quartile compared with highest; 95% confidence interval, 1.34-1.79; P<0.0001). This inverse relationship was independent of physician specialty and of hospital volume, was consistent across ICD subtypes, and was also evident for in-hospital mortality.Physicians who implant more ICDs have lower rates of procedural complications and in-hospital mortality, independent of hospital procedure volume, physician specialty, and ICD type.
Coronary Perfusion Pressure and the Return of Spontaneous Circulation in Human Cardiopulmonary Resuscitation
Authors: Norman A. Paradis
Journal: JAMA (1990)

Coronary perfusion pressure (CPP), the aortic-to-right atrial pressure gradient during the relaxation phase of cardiopulmonary resuscitation, was measured in 100 patients with cardiac arrest. Coronary perfusion pressure and other variables were compared in patients with and without return of spontaneous circulation (ROSC). Twenty-four patients had ROSC. Initial CPP (mean±SD) was 1.6 ± 8.5 mm Hg in patients without ROSC and 13.4 ± 8.5 mm Hg in those with ROSC. The maximal CPP measured was 8.4 ±10.0 mm Hg in those without ROSC and 25.6 ±7.7 mm Hg in those with ROSC. Differences were also found for the maximal aortic relaxation pressure, the compression-phase aortic-to— right atrial gradient, and the arterial Po<sub>2</sub>. No patient with an initial CPP less than 0 mm Hg had ROSC. Only patients with maximal CPPs of 15 mm Hg or more had ROSC, and the fraction of patients with ROSC increased as the maximal CPP increased. A CPP above 15 mm Hg did not guarantee ROSC, however, as 18 patients whose CPPs were 15 mm Hg or greater did not resuscitate. Of variables measured, maximal CPP was most predictive of ROSC, and all CPP measurements were more predictive than was aortic pressure alone. The study substantiates animal data that indicate the importance of CPP during cardiopulmonary resuscitation. (<i>JAMA</i>. 1990;263:1106-1113)
Are the recommendations being met in the general practice year of vocational training? Trainees' views in the West Midlands region.
Authors: A M Cyna, F R Przyslo
Journal: BMJ (1987)

Vocational trainees in the West Midlands who were in their general practice year were sent a postal questionnaire to find out whether there were important differences between the criteria for training of the 1986 West Midland postgraduate education committee (based on national recommendations) and the perceptions of the trainees of their current trainers and practices. The response rate was 86.2% (75 out of 87). Sixty four per cent (48) of trainees reported that they received on average less than the recommended minimum of three hours of teaching time a week. They felt that experience was inadequate in paediatric surveillance (62.7%) and preventive medical care (37.3%). Most trainers gave topic teaching (90.7%), and few used role play (5%). Most of the trainees (52%) had not signed a contract, a third did not get help with recommended allowances, and 37% thought that their progress had not been reviewed. Several trainees commented on the excellence of their training practices, and most of the practices appeared to be keeping to the spirit of the recommendations. There are, however, discrepancies between what some trainees feel they receive and what is recommended.
Tc-99m Phytate Bone Marrow Scintigraphy Showing Multiple Areas of Focal Hyperactivity in a Patient With Lung Cancer
Authors: CHENG-PEI CHANG, LEE-SHING CHU, REN-SHYAN LIU, SZU-MAN YU, SHIN-HWA YEH
Journal: Clinical Nuclear Medicine (1995)

Focal hyperactivity indicative of metastases is a rare finding in bone marrow imaging. In a lung cancer patient with multiple bony metastases, the Tc-99m phytate bone marrow imaging revealed multiple focal areas of increased radioactivity corresponding to the bone scan findings. The findings presented are consistent with a previous animal study, which found that phytate distribution was similar to that of diphosphonate in the skeletal system of rats and rabbits. The authors conclude that Tc-99m phytate should not be used as a bone marrow imaging agent. Further studies of Tc-99m phytate bone marrow scintigraphy on human beings are under way.
Inuit exposure to organochlorines through the aquatic food chain in arctic québec.
Authors: E Dewailly, P Ayotte, S Bruneau, C Laliberté, D C Muir, R J Norstrom
Journal: Environmental Health Perspectives (1993)

Inuit people (Eskimos) are likely exposed to persistent organochlorine compounds because their traditional diet includes fatty tissues of the arctic marine biota. Here we present the results of organochlorine compound analysis in milk fat samples from arctic Québec Inuit women and in fat tissues from various animal species inhabiting that region. The total concentration of polychlorinated biphenyl congeners in Inuit milk fat was similar to that of the beluga, while the profile of the 10 congeners resembled that of the polar bear. Mean concentrations of various organochlorines in milk-fat samples from Inuit women were between 2 and 10 times greater than those found in samples previously collected from southern Québec women. The Inuit mothers exhibit the greatest body burden known to occur from exposure to organochlorine residues present in the environment by virtue of their location at the highest trophic level of the arctic food web.
Blood-to-lymph migration of small lymphocytes through the liver of the sheep
Authors: Alan J. Young, Gregory M. T. Hare, John B. Hay
Journal: Hepatology (1994)

The process of lymphocyte migration is required for the systemic dissemination of immunological memory and immune surveillance. We report here experiments to quantitate the normal traffic of lymphocytes that occurs from blood to lymph through the liver and hepatic node in the sheep. Comparisons were made with known lymphocyte homing pools. Individual afferent hepatic lymphatics had cell outputs of 1.4 +/- 0.1 x 10(6) cells/hr, suggesting that the total combined lymphocyte output from the liver was no greater than about 1 x 10(7) cells/hr. The lymphocyte output in efferent hepatic lymph was 6.2 +/- 0.4 x 10(7) cells/hr, comparable to the cell outputs recorded from other lymph nodes of similar size. When the specificity of lymphocytes homing through the liver or hepatic node was examined, we found similarities to both the peripheral lymph node and intestinal lymph node homing patterns. Migration into afferent hepatic lymph was found to be different from that into intestinal or subcutaneous efferent lymph, and the kinetics of migration into hepatic afferent lymph was faster than that observed into efferent compartments. Intravenously injected endotoxin was found to alter the normal lymph flow through the liver tissue and the hepatic node; it appeared to enhance the migration of macrophages out of the liver by way of the afferent lymph. These studies suggest unique features of lymphocyte traffic through the liver and the need for further experiments on hepatic lymphocyte traffic, particularly in pathological states with substantial mononuclear cell infiltration.
Stokes-Adams Syndrome in Hodgkin's Granuloma
Authors: Alfred F. Goggio
Journal: JAMA (1961)

IT IS OUR PURPOSE to present a case in which Stokes-Adams attacks and evidence of heart disease were the first and continuing manifestations of Hodgkin's granuloma. Although it was a matter of some satisfaction that the correct etiologic diagnosis was made before surgical intervention confirmed its presence, this was so only after several diagnoses which seemed more probable had been discarded.  In a recent article inThe JournalJakob and Zirkin 1 presented 3 cases of involvement of the heart or pericardium in an autopsy series of 15 cases of Hodgkin's disease (from Mt. Sinai Hospital). Based upon their review of the literature they comment that this is a much higher incidence of cardiac and pericardial involvement than is usually found. Jackson and Parker 2 in their classic monograph found not a single case of myocardial involvement in 63 autopsy cases of Hodgkin's disease; there were, however, 2 cases showing
<i>WebM&amp;M</i> Launched
Authors: Brian Vastag
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
407 PROSPECTIVE RISK ASSESSMENT FOR HEPATOCELLULAR CARCINOMA RECURRENCE BY TRANSIENT ELASTOGRAPHY AFTER CURATIVE RADIOFREQUENCY ABLATION
Authors: R. Masuzaki, R. Tateishi, S. Shiina, H. Yoshida, H. Nakagawa, T. Arano, K. Uchino, K. Enooku, E. Goto, Y. Kondo, T. Goto, Y. Sugioka, H. Ikeda, M. Omata, K. Koike
Journal: Journal of Hepatology (2010)
Abstract 2508: Mass spectrometric immunoassay for insulin-like growth factor 1.
Authors: Dobrin Nedelkov, Eric Niederkofler, David Phillips, Bryan Krastins, Urban Kiernan, Kemmons Tubbs, Mary Lopez
Journal: Cancer Research (2013)

Abstract Mass Spectrometric Immunoassays (MSIA) are protein quantification methods that utilize mass spectrometric detection for quantification of targeted protein analytes affinity retrieved by surface-immobilized antibodies. This rather straightforward concept is realized through affinity pipette devices (MSIA-Tips) that enable high-throughput assaying of hundreds of samples per day. Described here is the development and validation of mass spectrometric immunoassay for insulin-like growth factor 1 (IGF1). MSIA-Tips derivatized with anti-IGF-1 antibody were used for affinity isolation of IGF1 from human samples. Long R3 (LR3) IGF1, spiked into samples prior to the affinity isolation, served as internal reference standard for signal normalization and IGF1 quantification. Following capture and elution, both the intact proteins and their surrogate tryptic peptides were analyzed via LC/MS. Linear standard curves were built that spanned the range of 1 to 1,500 ng/mL. The assay exhibited intra- and inter-assay precisions of &amp;lt;10%, and linearity and spiking-recovery in the 90 - 110% range. Data was compared to that obtained with a commercially available ELISA, yielding good correlation. The data correlation between intact IGF1 and peptide-based IGF1 MS analyses was good, demonstrating the applicability of the IGF1 MSIA across MS platforms. Citation Format: Dobrin Nedelkov, Eric Niederkofler, David Phillips, Bryan Krastins, Urban Kiernan, Kemmons Tubbs, Mary Lopez. Mass spectrometric immunoassay for insulin-like growth factor 1. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2508. doi:10.1158/1538-7445.AM2013-2508