tbuckley/cabot-search huggingface dataset:
ABC of Work Related Disorders: BUILDING RELATED ILLNESSES
Authors: P H Appleby
Journal: BMJ (1996)

Algal growth on drift eliminators of a building's cooling tower-a potential source of pollutants.* Eyes-irritated, itching, dry, watering * Nose-irritated, itching, runny, dry, blocked * Throat-sore, constricted, dry mouth * Head-headache, lethargy, irritability, difficulty in concentrating * Skin-dryness, itching, irritation, rashes Risk factors for sick building syndrome Characteristics of work and building * Sedentary occupation, clerical work * Sealed building and city centre * More than half of occupants using location display screen equipment for more * Large size-typically an occupied than 5 hours a day floor area greater than 2000 m2 * Maintenance problems identified * Centralised control of environmental * Low ceilings-typically lower than conditions-no local control of heating, 2.4 m ventilation, etc * Many changes or movements of * Building more than 15 years old furniture and equipment * Scruffy appearance * Public sector tenant or occupant * Large areas of soft furnishings, * Large areas of open shelving and carpets, and fabrics exposed paper Environmental factors * Low room humidities * Low supply'rate of outdoor air * High room temperatures * Smoking permitted in work areas * Excessive supply rate of outdoor air * Damp areas and mould growth * Dusty atmosphere * Dust, solvents, and ozone emissions * Gaseous emissions (volatile organic from printers and photocopiers compounds) from building materials * Low frequency fluorescent lamps and cleaning products creating subliminal flicker * Low frequency noise Criteria covered by Health and Safety (Display Screen Equipment) Regulations 1992 * Daily work routine of users * Requirements for workstations * Eye tests Display screen
Response to Comment on Underwood et al. Preoperative A1C and Clinical Outcomes in Patients With Diabetes Undergoing Major Noncardiac Surgical Procedures. Diabetes Care 2014;37:611–616
Authors: Patricia Underwood, Reza Askari, Shelley Hurwitz, Bindu Chamarthi, Rajesh Garg
Journal: Diabetes Care (2014)

We appreciate Dr. Dhatariya’s comments (1) and are glad to know that the Joint British Diabetes Societies have developed guidelines for optimal A1C levels before surgery. We were not aware of these guidelines and believe that most surgeons and anesthesiologists in the U.S. are not aware of them either. In our opinion, the literature to date has focused on perioperative glycemic control—on the day of …
Biliary stenting and successful intentional stent retrieval after 6 months in a benign stricture following hepaticojejunostomy
Authors: D. von Renteln, B. Riecken, M. Ulmer, K. Caca
Journal: Endoscopy (2007)

The management of benign biliary strictures remains a challenge for interventional endoscopists. Surgery, still the mainstay of treatment, is associated with nonnegligible morbidity and mortality. Recently, new techniques and devices for endoscopic therapy have become available [1] [2].
Detection of hepatitis B virus DNA in paraffin-embedded liver tissues in chronic hepatitis B or non-A, non-B hepatitis using the polymerase chain reaction
Authors: Michiko Shindo, Tadao Okuno, Ken Arai, Masayuki Matsumoto, Makoto Takeda, Kei Kashima, Mamoru Shimada, Yoshiaki Fujiwara, Yoshihiro Sokawa
Journal: Hepatology (1991)

We developed a polymerase chain reaction assay for the direct detection of hepatitis B virus in paraffinembedded liver tissue and applied this assay to determine whether hepatitis B virus DNA exists in livers with chronic hepatitis non-A, non-B. Fifty five liver biopsy samples were studied: 11 from patients with HBeAg-positive chronic hepatitis (paraffin-embedded) and 44 from patients with chronic hepatitis non-A, non-B (21 paraffin-embedded 25 fresh frozen). Thirty three (75%) of the non-A, non-B cases were positive for hepatitis C virus antibodies. Approximately 1 to 10 ng of DNA was extracted from the paraffin-embedded tissue and amplified using oligonucleotide (23-mer) primers specific for the S gene (positions 261 to 692). The β-globin gene was used as an internal control for sensitivity because this is a single copy gene and allows for relative quantification. In each of the chronic hepatitis B livers, the expected 432-base-pair amplification product for hepatitis B virus DNA and β-globin gene product were both detected. On the other hand, in the 21 paraffin-embedded chronic hepatitis non-A, non-B livers, no hepatitis B virus DNA was detected, although β-globin gene was observed in all. Furthermore, in all 25 frozen non-A, non-B livers, β-globin gene was observed, but no hepatitis B virus band was seen. The limit of detection of hepatitis B virus DNA by this method was estimated to be one genomic copy of hepatitis B virus DNA per cell. Thus all patients with chronic hepatitis B, but no patients with clinically diagnosed non-A, non-B hepatitis, had hepatitis B virus DNA in liver at a level of or above one copy per hepatocyte. (HEPATOLOGY 1991;13:167–171).
ED-10 * ASSOCIATIONS BETWEEN MATERNAL AND INHERITED GENETIC VARIATION IN FOLATE METABOLISM GENES AND PEDIATRIC BRAIN TUMORS IN A HIGH RISK POPULATION: A PILOT STUDY
Authors: K. Johnson
Journal: Neuro-Oncology (2014)

Folic acid is critically important for normal neural development and has been implicated in pediatric brain tumor (PBT) risk. However, much work remains in understanding the genetic basis of these associations among at-risk populations. Therefore, we examined inherited variation in folate metabolism genes on PBT risk in individuals with Neurofibromatosis Type 1 (NF1), a cancer predisposition syndrome. We also evaluated maternal genetic variation in these genes that could serve as a proxy for the intrauterine nutrient environment that may be important in PBT development. We recruited 56 families with a child with NF1 and a PBT from the Washington University NF1 Patient Registry Initiative (NPRI) (https://nf1registry.wustl.edu/) or the St. Louis Children's Hospital Neurofibromatosis Clinical Program. DNA isolated from blood or buccal samples representing 45 triads (mother, father, child) and 11 dyads (mother, child) were analyzed using 49 tag single nucleotide polymorphisms (SNPs) genotyped on the Sequenom platform. Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between maternal and offspring minor alleles and PBTs were estimated using log linear regression models. Significant/marginally significant associations between PBTs and each additional offspring copy of the minor allele were found for MTRR rs10520873 (OR = 0.5; 95% CI 0.3-1.0); MTR rs4659745 (OR = 0.5, 95% CI 0.2-0.9), rs3768147 (OR = 1.9; 1.1-3.3), rs12759827 (OR = 0.5, 95% CI 0.3-1.0); and DHFR rs10072026 (OR = 0.2; 95% CI 0.03-0.7). For maternal SNPs, significant/marginally significant associations were observed with each additional maternal copy of the minor allele for MTRR rs1802056 (OR = 1.94; 95% CI 1.1-3.6); SLC19A1 rs1051298 (OR = 2.0; 95% CI 1-3.4), rs2838957 (OR = 1.8; 1.0-3.4), rs4818789 (OR = 1.9; 95% CI 1.0-3.8), TYMS rs15872 (OR = 0.6; 95 %CI 0.3-1.0); and MTHFR rs3737964 (OR = 2.1; 95%CI 1.0-4.5) and rs1801133 (OR = 0.4; 95% CI 0.2-0.8). While our findings require validation, they suggest that inherited and maternal genetic variation in folate metabolic genes may influence PBT risk in children with NF1.
Treatment of Congenital Hernia
Authors: L. W. Marshall
Journal: BMJ (1888)

am aequainted.-Mesrs.Reynolds and Branson have made some ,ompressed tabloids, each containing forty grains, that is, sufficiant to make a quart of solution.They have also been good enough to carry out my wishes in making a dressing of "salufer" wool.;In all the cases related this " salufer" wool has been the dressing employed, a layer of gauze wet with the "salufer" lotion covering the wound, and intervening between it and the wool.
Osteopathy, Chiropractic, and Spinal Manipulation
Authors: Michael A. Patmas
Journal: Annals of Internal Medicine (1993)

Letters15 April 1993Osteopathy, Chiropractic, and Spinal ManipulationMichael A. Patmas, MDMichael A. Patmas, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-8-199304150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Shekelle and colleagues [1] suggest that the risk of spinal manipulation is low because they could only identify nine reports of manipulation-related complications. In 1985, I identified 33 separate reports of various injuries caused by chiropractic spinal manipulation (Table 1).Table 1. Reported Complications of Chiropractic Manipulation Over a 3-year period in a general medical practice, Livingston [2] examined 676 patients with back pain. Of these, 172 (25%) had seen a chiropractor previously, and 12 (7%) had received some sort of injury, primarily to soft tissue. Of greater concern are ...References1. Shekelle PG, Adams AH, Chassin MR, Hurwitz EL, Brook RH. Spinal manipulation for low-back pain. Ann Intern Med. 1992; 117:590-8. Google Scholar2. Livingston MC. Spinal manipulation causing injury. A three year study. Clin Orthop. 1971; 81:82-6. Google Scholar3. Sherman DG, Hart RG, Easton JD. Abrupt change in head position and cerebral infarction. Stroke. 1981; 12:2-6. Google Scholar4. Robertson JT. Neck manipulation as a cause of stroke. Stroke. 1982; 13:260-1. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1993Volume 118, Issue 8Page: 651-653KeywordsBrainChiropracticHeartInfarctionLower back painOsteopathyRisk managementSoft tissuesSpinal cordStroke ePublished: 15 August 2000 Issue Published: 15 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Complement C3 proteins in psoriasis
Authors: F. ACEVEDO, H. HAMMAR
Journal: British Journal of Dermatology (1989)

A new polymorphism of the complement factor C3 in human plasma was demonstrated by isotachophoresis in agarose gels followed by immunodetection with rabbit anti‐human C3c and C3d immunoglobulins. Four bands were detected in the immunoprint of freshly drawn EDTA‐plasma, which were C3s1, C3s2, C3f1 and C3f2. At least four additional C3 components in Mg2+‐zymosan activated plasma were present, which were C3b1 to C3b4. The different forms of C3 in frozen and thawed heparin‐plasma from 20 patients with psoriasis and 20 healthy individuals were studied from the immunoprint. The total content of C3 components was 29% greater in the patients with psoriasis than controls. The major difference was in the C3b components which were increased by 46%. In psoriatic patients, the two slow C3 components C3s1 and C3s2 were increased by 24 and 56% respectively, when compared with controls. The two fast C3 components C3f1 and C3f2 were decreased to 29 and 37%. The results suggest a direct involvement of the complement factor C3 in psoriasis.
THE UMBILICAL CORD
Authors: NORRIS W. VAUX
Journal: JAMA (1926)

This universally present structure in childbirth has had little, if any, recent investigation. The older writers on obstetric practice and midwifery often failed even to mention the cord, other than its presence and how to ligate and sever it, which leads us to believe that little, if any, serious consideration or significance was attached to its structure.  Further, in the works on obstetrics that embody the physiology, pathology and embryology of more recent date, there will be found little new, other than the accepted facts of long standing regarding the twists or spirals present in the cord, its length, the tensile strength, and a brief description of its formation, function and embryonic development.  Occasional abnormalities are mentioned, such as knots and abnormal attachments of the cord to the placenta.  When more recent investigation and attention was brought to bear on the placenta, its structure and functions, the funis, or naval
THE ROLE OF DEAD AND INFECTED TEETH IN AUTOGENOUS INFECTIONS
Authors: A. P. Bertwistle
Journal: BMJ (1928)

MC BRDiTL 589 a strongly positive complement-fixation reaction for typhoid, but his Widal reaction was negative from the start, and remained so for some weeks after.The three natives who persistently showed negative blood reactions aiid negative findings in both urine and stools were dis- charged from the isolation hospital after four weeks and returned to the dairy.It was thought that one miiight rely, if not on their natural inmmunity, then on the imi- munity acquired from the Besredka prophylactic treat- ment.This left five boys, one of them the urinary carrier, anid the four others giving positive complement-fixation but negative Widal reactions, and negative findings in stools and urine.After the urine and stools had been examined five times, and it had been noticed that during these weeks their complement-fixation reactions had become weaker and weaker, it was considered that it was safe for them to return to work, and they were allowed to resume work at the dairy.The only one then left over was the urinary carrier; his blood gave a persistently positive complement-fixation reaction, and his urine every week showed typhoid bacilli.It was not to be exl)ected that Besredka treatment could have had any effect on this -condition.Treatment was therefore instituted with ordinary typhoid vaccine given under the skin, and large doses of urotropine, but after many weeks, although the
Unilateral Paralysis of the Diaphragm and Larynx Associated with Inflammatory Lung Disease
Authors: B. Freedman
Journal: Thorax (1950)

Unilateral paralysis of the diaphragm, not the result of a deliberate operative procedure, is uncommon.It may have a variety of causes, but so far as I am aware pneumonia* has never previously been included amongst them.The commoner causes of unilateral paralysis are diseases of the cervical spinal cord affecting the anterior horn cells of the fourth segment, such as poliomyelitis, tumour, progressive muscular atrophy, myelitis, haemorrhage, and injuries and caries of the cervical vertebrae.Peripheral lesions of the phrenic nerve or its roots include neck wounds, polyneuritis (usually diphtheritic), destruction by neoplastic masses (usually near the hilum of the lung), and avulsion from birth injury as an extension of Erb's palsy, of which about 20 cases have been described.A number of cases occurring during the course of pulmonary tuberculosis have been ascribed to involve- ment of the phrenic nerve in scar tissue.Two instances in newborn infants, not associated with Erb's palsy, were attributed to intrauterine malposition (Blattner, 1942; Light, 1944).An aortic aneurysm may rarely be responsible (Sanguinetti and Galzerano, 1943).Eventration of the diaphragm, a condition in which the affected dome is much raised and thinned with fibrous replacement, may in a sense be regarded as a form of phrenic palsy.Though usually regarded as congenital, it may in some instances be the atrophic result of permanent interruption of the nerve supply.Diseases of the diaphragm itself, acute diaphragmitis (Hedblom's syndrome), trichiniasis, and the degenerations that may result from prolonged contact with purulent effusions, severe pneumonia and asphyxial states, all of course impair diaphragmatic function, which would imply impaired descent on inspiration.Whether they would cause actual paralysis is open to question.A search of the literature has failed to reveal any previous record of unilateral paralysis of the diaphragm due to pneumonia.Upward displacement of the diaphragm in pneumonia has been reported by Wu (1932), but such elevation is apparent only, being in fact a failure to descend during deep inspiration as much as the dome of the sound side.It is due to a loss of expansibility of the lung result- ing from the consolidation, and is apparent only in radiographs taken in full inspira- tion.The extensive reviews by Graeser, Wu, and Robertson (1934), Davies, Hodgson, and Whitby (1935), and Heffron (1939) of the radiological findings in pneumonia likewise mention this apparent elevation during the acute phase, but *Throughout this article the term " pneumonia " is used to cover a variety of inflammations affecting the lung.-EDITOR.
380. Alternative Cellular Receptor for B_Group Adenoviruses: Implications for Gene Therapy
Authors: Sebastian Tuve, Hongjie Wang, Anuj Gaggar, Ying Liu, Andre Lieber
Journal: Molecular Therapy (2006)

Human adenoviruses (Ads) have been classified into six species (A_F), currently containing 51 serotypes. Human Ads have a broad tropism, causing infection of the urinary tract, kidney, eye, gastrointestinal tract and lymphoid tissue. The outer Ad protein capsid mainly consists of three polypeptides: the penton base, the hexon, and the fiber protein. The major determinant for Ad attachment to host cells is the C_terminal (knob) domain of the fiber protein. Most serotypes belonging to species A, C, E and F are considered to attach cells by binding to the coxsackie_adenovirus receptor (CAR). In contrast, group_B Ad serotypes (Ad3, 7, 11, 14, 16, 21, 35, 50) use a cellular receptor that is different from CAR, therefore representing a unique group within the adenovirus family. We and others have recently identified CD46 as a cellular receptor used by B_group Ads. Here we show evidence that B_Group Ads utilize an additional receptor for infection of human cells, which is different from CD46. MATERIAL AND METHODS: Adenovirus serotypes 3, 7, 11, 14, 16, 21, 35 and 50 were radio_labeled and used for binding and internalization studies on cells. For the purpose of competing adenoviral binding we produced and purified soluble CD46 protein and adenovirus fiber protein from Ad3, 11 and 35 knobs. RESULTS: Competition studies using unlabeled and labeled Ads, recombinant Ad fiber knobs, soluble CD46 and a CD46 antibody reveal three different subgroups of B_group Ads, in terms of their receptor usage; Group1 (Ad16, 21, 35 and 50) nearly exclusively use CD46. Group2 (Ad11p) uses both, CD46 and an alternative receptor. Group3 (Ad3, 7p and 14) utilize an alternative receptor and not CD46. The alternative receptor is expressed at varying levels in normal, malignant, mesenchymal and hematopoietic stem cells. Pretreatment of cells with Trypsin revealed that the alternative receptor is a protein. Deglycosylation of cells using Tunicamycin indicated that glycosylation is important for binding of Ads to the alternative receptor. CONCLUSIONS: The fact that B_group Ads bind to CD46 and, in addition to an alternative receptor, is important for both understanding the molecular mechanism of adenovirus infection and developing B_group Ads as tools for gene therapy. Our current studies are focused on the identification of the alternative receptor and, in consideration of their high tropism towards the alternative receptor, on the development and assessment of Ad3, 7, and 14 as gene transfer vectors.
Mentally III Mothers and Their Children
Authors: Martin R. Lipp
Journal: JAMA (1975)

In 1960 Dr. Henry Grunebaum initiated a joint admission program in which a psychiatrically ill mother and her young child were admitted together to a ward at the Massachusetts Mental Health Center. The influence of that experiment has spread to other centers, although the practice is still a long way from universal acceptance. The present volume represents a 14-years review of the program begun by Dr. Grunebaum, together with interdisciplinary reportage of what from the beginning has been an interdisciplinary effort. The authors include a psychiatrist, two psychologists, an educator, and a nurse. The book reports "a series of loosely complementary studies involving overlapping but not identical populations." Very useful comments on practical considerations for the implementation of a joint admission program occupy the first portion of the book, with special emphasis on personal reactions of patients, staff, and others to having a baby on an adult psychiatric ward. The
Abstract 499: RUNX2 protects human neuroblastoma cells against apoptosis
Authors: Manu Gnanamony, Indra Mohanam, Sanjeeva Mohanam
Journal: Cancer Research (2014)

Abstract Neuroblastoma is the most common extracranial pediatric solid tumor with an undifferentiated status and is characterized by heterogeneous clinical courses. The RUNX gene family comprises RUNX1, RUNX2, and RUNX3 transcription factors and is closely involved in a variety of cellular processes including development, differentiation, and tumorigenesis. Since RUNX genes play crucial roles in neuronal differentiation, we studied the expression of RUNX mRNAs in human neuroblastoma NB1691 cells. An increased RUNX2 mRNA expression was found in NB1691 cells compared with RUNX1 and RUNX3 mRNAs. Hypoxia is known to be a significant physiological stress in the tumor microenvironment and is associated with tumor malignant phenotype. NB1691 cells exhibited an increased expression of RUNX2 mRNA upon exposure to hypoxia compared with normoxic cells. Knockdown of HIF-2α, but not HIF-1α, decreased hypoxia-induced up regulation of RUNX2 mRNA in NB1691 cells. BothHIF-1α and HIF-2α mRNAs as well as proteins were downregulated in hypoxic NB1691 cells treated with RUNX2 siRNA compared with non-targeted control siRNA. GLUT1, a HIF-1α downstream target gene and Oct4, a HIF-2α downstream target gene were also found to be decreased in RUNX2 siRNA-treated NB1691 cells exposed to hypoxia. Runx2 knockdown using RNA interference in NB1691 cells resulted in decreased cell proliferation under normoxic as well as hypoxic conditions. An increased percentage of apoptotic cells was found in NB1691 cells treated with RUNX2 siRNA, and this percentage further increased in hypoxic NB1691 cells treated with RUNX2 siRNA. Further, these observations were validated by TUNEL assay. Real-time PCR analysis revealed elevated levels of Bax, Puma, Noxa and Nix in NB1691 cells treated with RUNX2 siRNA compared with cells treated with non-targeted control siRNA-treated cells under hypoxic conditions. In conclusion, our study suggests that hypoxia up regulates RUNX2 in NB1691 cells in a HIF2α- dependent manner and RUNX2 protects neuroblastoma cells against apoptosis. Citation Format: Manu Gnanamony, Indra Mohanam, Sanjeeva Mohanam. RUNX2 protects human neuroblastoma cells against apoptosis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 499. doi:10.1158/1538-7445.AM2014-499