Haemobartonella and Systemic Lupus Erythematosus
Authors: FREDERIC C. MCDUFFIE
Journal: Annals of Internal Medicine (1972)

Editorial Notes1 September 1972Haemobartonella and Systemic Lupus ErythematosusFREDERIC C. MCDUFFIE, M.D.FREDERIC C. MCDUFFIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-3-470 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe newest candidates for the role of causative agents in systemic lupus erythematosus are the haemobartonella and related rickettsiae, small coccoid organisms commonly associated with the production of hemolytic anemia in several animal species. Kallick and associates (1) have reported finding small round bodies, 0.3 to 0.5 mm in diameter, in erythrocytes of eight consecutive patients with systemic lupus erythematosus. These bodies produced bright fluorescence after being stained with acridine orange, a dye with a strong affinity for RNA and DNA. Acridine orange produces similar staining of haemobartonella in smears of infected rats, cats, and guinea pigs (2). The same...References1. KALLICKLEVINREDDI CSK: Systemic lupus erythematosus associated with haemobartonella-like organisms. Nature New Biol (Lond) 236:145-146, 1972 CrossrefMedlineGoogle Scholar2. RISTIC M: Anaplasmosis. Adv Vet Sci Comp Med 6:111-192, 1960 Google Scholar3. FORDMCCANDLISH DL: Isolation of TRIC agents from the human genital tract. Br J Vener Dis 45:44-46, 1969 MedlineGoogle Scholar4. KREIERRISTIC JM: Haemobartonellosis, eperythrozoonosis, grahamellosis and ehrlichiosis, in Infectious Blood Diseases of Man and Animals, vol. II, edited by WEINMAN D, RISTIC M. New York, Academic Press, 1968, pp. 387-472 CrossrefGoogle Scholar5. SINKOVICSGYORKEYTHOMA JFG: A rapidly fatal case of systemic lupus erythematosus: structures resembling viral nucleoprotein strands in the kidney and activities of lymphocytes in culture. Texas Rep Biol Med 27:887-908, 1969 MedlineGoogle Scholar6. TISHERKELSOROBINSON JHR. Intraendothelial inclusion in kidneys of patients with systemic lupus erythematosus. Ann Intern Med 75:537-547, 1971 LinkGoogle Scholar7. UZMANSAITOKASAC BHM: Tubular arrays in the endoplasmic reticulum in human tumor cells. Lab Invest 24:492-498, 1971 MedlineGoogle Scholar8. NORTON W: Endothelial inclusions in active lesions of systemic lupus erythematosus. J Lab Clin Med 74:369, 1969 MedlineGoogle Scholar9. MORRISRISTICLYKINS HMJ: Characterization of opsonins eluted from erythrocytes of cattle injected with Anaplasma marginale. Am J Vet Res 32:1221-1228, 1971 MedlineGoogle Scholar10. DAMESHEKREEVES WW: Exacerbation of lupus erythematosus following splenectomy in "idiopathic" thrombocytopenic purpura and autoimmune hemolytic anemia. Am J Med 21:560-566, 1956 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mayo Clinic Rochester, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEhrlichia and bone marrow cells: Could Ehrlichial infection explain the unsuspected etiology of some diseases of the immune system? 1 September 1972Volume 77, Issue 3Page: 470-471KeywordsDNAGuinea pigsHemolytic anemiaLupus erythematosusRNAStaining Issue Published: 1 September 1972 PDF DownloadLoading ...