tbuckley/cabot-search huggingface dataset:
HEALTH BOARDS AS DISTURBERS OF THE PEACE.
Authors: CHARLES McINTIRE
Journal: JAMA (1896)

ers, that as they pass each other exchange smiles and wave friendly greetings; war with privateers and bat- tleships commissioned to rob, kill and destroy.How peace, by encouraging thought, industry, invention, discovery, enterprise, science and art among the mil- lions of earth's inhabitants, stores up billions upon billions of accumulated value-crystallized profitcoined capital-thus furnishing means for additional strides in the path of upward progress.How war, both by paralyzing the agencies of peace and by a wholesale process of consumption and waste, by enor- mous reduction of income and extravagant expenditures, exhausts the treasuries of states, of nations, and often of the entire civilized world; then resorts to promissory paper and accumulates public debts to amounts of billions upon billions, tempting following generations of children to repudiation, or subjecting them to endless oppressive, impoverishing, vexatious, demoralizing taxation for the payment of claims which they did not contract and did not approve.How peace, for all the countless and boundless bene- fits it creates and bequeaths, expects, and, as a rule, receives no state appropriations for its veterans and dependents, leaves no public debt and imposes no tax.Ben Franklin sent heavenward an ardent invocation.His prayer mounted up to a dark cloud that was flashing with lightning.From the midst of the cloud there descended a great angel agent and filled a .vialwith blessings to be poured out upon the inhab- itants of the earth-blessings that now fill not only all lands but also all seas.They are blessings, the fruits of peace, priceless but costless.Franklin's compen- sation is the halo of glory that encircles his name.The like is true of Galvani, Faraday, Morse, Roentgen,and of the great host of scientists whose gratuitous but inval- uable achievements can be accomplished only in the quiet retreats of peace.From the same beneficent , retreats, in our own days, came the discovery of anes- thesia, all without cost.A great phantom-like appa- rition that made its first earthly advent, that Eve might be born from Adam's painless side, and its sec- ond in the fullness of time for the fulfillment of the prediction: "There shall be no more pain."Long, Wells, Jackson and Morton received no compensation or pension.Military and naval academies, navy yards, veterans
865 12 WEEK RESPONSE-GUIDED TREATMENT WITH THE NS5A INHIBITOR, GS-5885, THE NS3 PROTEASE INHIBITOR, GS-9451, PLUS PEGYLATED INTERFERON/RIBAVIRIN IN TREATMENT NAÏVE GENOTYPE 1 HEPATITIS C INFECTED PATIENTS
Authors: P. Marcellin, M.P. Manns, E. Janczewska, A.J. Muir, X. Wu, J.D. Trenkle, B. Kanwar, M. Subramanian, J.G. McHutchison, S.C. Gordon, I.M. Jacobson
Journal: Journal of Hepatology (2013)
The regulation of calcitonin in normal human plasma as assessed by immunoprecipitation and immunoextraction.
Authors: J G Parthemore, L J Deftos, D Bronzert
Journal: Journal of Clinical Investigation (1975)

We have studied the secretion of calcitonin in normal adults with a new procedure of increased sensitivity for the measurement of the hormone in peripheral plasma. In this method, endogenous calcitonin is immunoprecipitated with specific antibodies from a 10-ml plasma sample. The calcitonin is then dissociated from the antibodies and extracted into alcohol. The alcohol is evaporated, and the calcitonin is recovered in assay diluent for subsequent radioimmunoassay. The procedure produces a fivefold increase in immunoassay sensitivity and eliminates plasma proteins which can produce spurious immunoassay effects. This procedure was used to measure calcitonin in normal adults. The mean (+/- SE) plasma calcitonin in 43 subjects was 10 (+/- 2) pg/ml. A+ the end of a 3-h calcium infusion (12 mg/kg), mean plasma calcitonin in 10 subjects had risen to 114 (+/- 21) pg/ml. In 11 subjects, a 10-min infusion of 150 mg of calcium caused calcitonin to rise to a mean concentration of 28 (+/- 7) pg/ml at 20 min. EDTA infusion (50 mg/kg 2 h) caused a slight decrease in plasma calcitonin. These results are consistent with our previous reports of the low concentrations of calcitonin in adult plasma. Our data may underestimate calcitonin levels since not all of the heterogenous species of hormone may be extracted by this method. In any case, this procedure has allowed us to determine that the low concentrations of plasma calcitonin in normal adults are responsive to perturbations of calcium homeostasis. The immunoextraction method may be applicable to other assays in which it is necessary to increase sensitivity or define specificity.
BIMANUAL VIBRATORY PALPATION.
Authors: HOWARD A. KELLY
Journal: JAMA (1907)

In making a bimanual examination of the kidney or of a uterine or ovarian tumor it is often difficult to determine with great precision the extreme boundaries of the growth or of the misplaced organ. There is often a doubtful zone, around the more central manifestly resistant part of the tumor, where it shades off into the surrounding tissues. The result attained by the customary methods of palpation may be said to yield the umbra or the more definitely resisting portion, while outside of the umbra lies a zone which we may call the penumbra or the doubtful area. Now, if I could only so palpate as to recognize the changes of consistency between the penumbra and its enveloping tissues I would then be able to enlarge the boundaries of the tumor or organ in question and so to reach more definite results. A bimanual palpation concerns itself with these
Resorbable and non-resorbable augmentation devices for tenorrhaphy of xenografts in extensor tendon deficits: 12 week study
Authors: K.N. Madden, K.A. Johnson, C.R. Howlett, B.K. Milthorpe, G. Robins, Y. Ikada, K. Schindhelm
Journal: Biomaterials (1997)
European Commission urges governments to reduce hospital acquired infections
Authors: R. Watson
Journal: BMJ (2008)

The European Commission sent a series of recommendations on 15 December to national governments in a bid to improve the safety of patients and to reduce the millions of hospital acquired infections each year.

The Stockholm based European Centre for Disease Prevention and Control says that one in 20 hospital patients in Europe—some four million people—become infected while in hospital. Such infections are estimated to be the direct cause of 37 000 deaths annually and to be a contributory factor in a further 110 000.

Besides common micro-organisms such as the resistant strain …
HPLC-MS analysis of Schisandra lignans and their metabolites in Caco-2 cell monolayer and rat everted gut sac models and in rat plasma
Authors: Jia-ming Yang, Siu-po P. IP, Hok-keung J. Yeung, Chun-tao Che
Journal: Acta Pharmaceutica Sinica B (2011)

The absorption profiles of Schisandra chinensis were evaluated using the human Caco-2 cell monolayer and rat everted gut sac models, as well as in rat plasma. By analyzing the chromatographic and MSn characteristics of individual peak acquired by HPLC-DAD-APCI-MSn determination, thirteen lignans were identified as the major in vitro absorbable components of the Schisandra extract. Most of these compounds were also detected and identified in rat plasma after an oral administration of the Schisandra extract, except for angeloyl(tigloyl)gomisin H and angeloyl(tigloyl)gomisin Q, whose structures possess an ester group at the cyclooctadiene ring. In addition, four metabolites, corresponding to the hydroxylation and demethylation products of schisandrin and the hydrolysis derivative of angeloyl(tigloyl)gomisin Q, were tentatively identified. The results demonstrate that Schisandra lignans are the major absorbable components of this crude drug, and hydroxylation, demethylation and hydrolysis are important metabolic transformations of the absorbable lignans.
Cancer Survivorship: Today and TomorrowHandbook of Cancer Survivorship
Authors: Daniela Dornelles Rosa
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aortic Disease with Valvular Insufficiency as the Principal Manifestation of Systemic Lupus Erythematosus
Authors: G. C. BERNHARD
Journal: Annals of Internal Medicine (1969)

Three examples of death due to noninfectious aortic insufficiency in a series of 52 patients who had systemic lupus erythematosus are described. Aortic-wall disease was also present. Marked valve-leaflet thinning and central perforations were seen without verrucous endocarditis in two patients at autopsy.
Response to Letter Regarding Article, “Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism”
Authors: Toru Hosoda, Hanqiao Zheng, Mauricio C. Cabral-da-Silva, Fumihiro Sanada, Noriko Ide-Iwata, Barbara Ogórek, João Ferreira-Martins, Christian Arranto, Domenico D'Amario, Federica del Monte, Konrad Urbanek, David A. D'Alessandro, Robert E. Michler, Piero Anversa, Marcello Rota, Jan Kajstura, Annarosa Leri
Journal: Circulation (2011)
Estrogens in Beef Production
Authors: John R. Evrard
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The question about estrogens in beef production (227:1067, 1974) was probably answered before the Food and Drug Administration (FDA) withdrew its ban on diethylstilbestrol in animal feed. At any rate, in January 1974, the FDA again allowed this agent to be used in animal foods. The question and answer supplied will have to be reevaluated in light of the fact that we now may again be eating meat and poultry that does have residuals of diethylstilbestrol in the particular food product.
Cardioprotective effect of hormone replacement therapy in postmenopausal women: is the evidence biased?
Authors: W F M Potshuma, R G J Westendorp, J P Vandenbroucke
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objective</b> : To quantify the effect of selection of relatively healthy women in studies reporting reduced relative risk for cardiovascular disease in postmenopausal women taking hormone replacement therapy. Design - Review of the follow up studies reported in three recent meta- analyses to determine the effect of oestrogen therapy on both total cancer and cardiovascular disease. The same standard statistical methods as in the original analyses were used. <b>Main outcome measures</b> : Relative risks of total cancer and cardiovascular disease. <b>Results</b> : In most of the follow up studies the relative risk for total cancer was below 1. The studies that showed the largest reduction in cardiovascular disease also showed the largest reduction in cancer, indicating a healthy cohort effect. Although heterogeneity within the studies prevented pooling, the best estimate for the protective effect on total cancer was a relative risk of 0.83 among women taking oestrogen (95% confidence interval 0.71 to 0.96), while in the same studies the relative risk for cardiovascular disease was 0.57 (0.50 to 0.64). <b>Conclusions</b> : Unintended selection of relatively healthy women for oestrogen therapy may have influenced the reported beneficial effect of oestrogen therapy on cardiovascular disease. It is unclear how much of the cardioprotection is due to this selection. Universal preventive hormonal replacement therapy for postmenopausal women is unwarranted at present.
73 WORLDWIDE EXPERIENCE TREATING CHRONIC HEPATITIS C (CHC) WITH PEGINTERFERON ALFA/RIBAVIRIN: FINAL RESULTS FROM 7163 NAIVE, MONO-INFECTED PATIENTS ENROLLED IN THE LARGE MULTINATIONAL PROPHESYS COHORT STUDY
Authors: P. Marcellin, H. Cheinquer, M. Curescu, G.M. Dusheiko, P. Ferenci, A. Horban, D. Jensen, G. Lengyel, A. Mangia, D. Ouzan, M. Puoti, M. Rodriguez-Torres, M.L. Shiffman, M. Schmitz, F. Tatsch, M. Rizzetto
Journal: Journal of Hepatology (2012)
Huntington's Chorea
Authors: George W. Paulson
Journal: JAMA (1982)

Michael Hayden's book<i>Huntington's Chorea</i>(a deliberately different title than the current label of "Huntington's disease") is the first single-authored monograph available on the topic and is a remarkably accomplished discussion of this incurable disease. In contrast to previous multiauthored reviews of the best known of all dominantly inherited diseases, Hayden's monograph touches every aspect of recent research, emphasizes clinical data, and is blessed by smooth writing and skillful editing. The tables in particular are enlightening, with clear illustrations to convey both the social impact and the scientific facts. Using his own collection and the extensive bibliography compiled by fellow members of the Committee on Huntington's Disease of the World Federation of Neurology, Hayden presents a broad historical and epidemiologic approach to the disease. The author's research in South Africa emphasized the relative rarity of the disease among Africans, and he details historical explanations of the worldwide geographic clusters of
THE MEDICAL EXAMINER SYSTEM
Authors: J. Graham Harkness
Journal: JAMA (1927)

<h3>To the Editor:</h3> —In the interesting article inThe Journal, August 20, on the Medical Examiner System, there is a slight error in the historical part. It is stated that "the first formal statute after Magna Charta dealing with the Coroner is that of Edward the Confessor in the year 1276 (4. Ed. 1., de officio coronatoris)." Edward the Confessor was of course the last but one of the Saxon kings and lived more than 150 years before Magna Charta. He was a great saint, starting the building of Westminster Abbey, but not a wise king. Edward I, a wise king, was far from being a saint. May I express in conclusion the gratification that I, along with many other Canadians, feel in the increasing interest shown in the better class of American publications in the history of our common mother.
Trustwide audit on mental capacity
Authors: G. Mehta, A. Phipps
Journal: BMJ (2008)

With regard to mental capacity and psychiatric admission,1 2 we carried out a trustwide audit into mental capacity assessment and documentation in North East London Mental Health Trust in September-November 2007, the Mental Capacity Act 2005 having been implemented in April 2007. The standard used for the audit was that the mental …
Abstract 3687: Expression of a Src-family kinase in CML cells induces resistance to imatinib in a kinase-dependent manner
Authors: Teodora Pene-Dumitrescu, Thomas E. Smithgall
Journal: Cancer Research (2010)

Abstract Chronic Myelogenous Leukemia (CML) is characterized by the presence of Philadelphia Chromosome, which results in the expression of the 210 kDa Bcr-Abl tyrosine kinase. Bcr-Abl constitutively activates signaling pathways important for the proliferation, survival and cytokine independence of myeloid progenitors, including the Src family kinases (SFKs). Imatinib, an inhibitor of Bcr-Abl tyrosine kinase activity, is the frontline therapy for CML. Although imatinib is remarkably effective in the chronic phase of the disease, patients with accelerated or blast crisis CML often develop resistance. Several recent studies performed on clinical specimens from imatinib-resistant patients with wild-type Bcr-Abl found that the Src family kinase members Hck and Lyn are overexpressed or highly active, suggesting that Src kinases may play a role in imatinib resistance. While the role of Lyn has been addressed in some detail, the contribution of Hck to this type of imatinib resistance is less well understood. To test whether Hck overexpression in CML cells induces resistance to imatinib in a kinase-dependent manner, we employed a Hck mutant (Hck-T338A) that is uniquely sensitive to the pyrazolo-pyrimidine inhibitor, NaPP1. In vitro, Hck-T338A was 48 times more sensitive to NaPP1 than the wild-type kinase. Importantly, this “gatekeeper” mutation was functionally silent and did not confer a loss or gain of function on Hck in a control fibroblast transformation assay. Expression of wild-type Hck or the T338A mutant in K562 CML cells resulted in resistance to imatinib-induced apoptosis and inhibition of soft-agar colony formation. Treatment with NaPP1 restored sensitivity to imatinib in a concentration-dependent manner only in cells expressing the Hck-T338A mutant. In contrast, cells expressing wild-type Hck were not affected by NaPP1, demonstrating the selectivity of NaPP1 for the Hck-T338A mutant. This result shows that Hck-induced imatinib resistance requires Hck kinase activity. In addition, NaPP1 also reduced Hck-mediated phosphorylation of Bcr-Abl at sites that may affect imatinib binding exclusively in cells expressing Hck-T338A. Together, these data establish a direct cause and effect relationship between Hck overexpression and imatinib resistance in CML cells. Furthermore, our results show that imatinib resistance requires Hck kinase function and may occur via direct Hck-induced trans-phosphorylation of Bcr-Abl. Selective drug targeting of Hck may be of therapeutic benefit in imatinib-resistant CML patients with increased Hck expression or activity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3687.
β-Cell Dysfunction in Classic Transient Neonatal Diabetes Is Characterized by Impaired Insulin Response to Glucose but Normal Response to Glucagon
Authors: Giuliana Valerio, Adriana Franzese, Mariacarolina Salerno, Gianluca Muzzi, Gaetano Cecere, Karen I. Temple, Julian P. Shield
Journal: Diabetes Care (2004)

OBJECTIVE—To investigate β-cell function and the long-term health of four case subjects presenting with chromosome 6–associated transient neonatal diabetes (TND). RESEARCH DESIGN AND METHODS—Two unrelated case subjects presenting with paternal uniparental isodisomy of chromosome 6 (UPD6) and two siblings with a paternally inherited duplication of 6q24 were studied. Three case subjects presented with neonatal diabetes that recurred at 4–17 years, while diabetes was incidentally discovered in the other case subject at 14 years of age. β-Cell function was investigated after diabetes relapse by means of an oral glucose tolerance test (OGTT), an intravenous glucose tolerance test (IVGTT), and glucagon tests. The quantitative insulin sensitivity check index (QUICKI) was calculated from fasting blood samples as an estimate of insulin sensitivity. RESULTS—β-Cell function was investigated at diabetes relapse in two case subjects: the insulin response to both an OGTT and IVGTT was low, whereas the basal levels of C-peptide were normal. No evidence of insulin resistance was found. Residual β-cell function was further explored by a glucagon test in all subjects at the age of 16–28 years and was found to be normal. Final height was within the normal percentiles, whereas one case, who had been poorly controlled since puberty, presented with diabetes-related microvascular complications. CONCLUSIONS—In patients with chromosome 6–associated TND, the β-cell is preserved and able to secrete insulin through the stimulatory G protein pathway while exhibiting a specific defect of insulin secretion after glucose stimulation. This form of diabetes can be managed with insulin or diet, although new therapeutic agents (glucagon-like synthetic analogs) may prove useful in the future. Lack of treatment leads to long-lasting hyperglycemia without the risk of ketoacidosis but associated with microangiopathy in adult life.
Comparative Analysis of the 100 kb Region Containing the <i>Pi-k</i> <i>h</i> Locus Between <i>Indica</i> and <i>Japonica</i> Rice Lines
Authors: S.P. Kumar, V. Dalal, N.K. Singh, T.R. Sharma
Journal: Genomics Proteomics & Bioinformatics (2007)

We have recently cloned a pathogen inducible blast resistance gene Pi-k(h) from the indica rice line Tetep using a positional cloning approach. In this study, we carried out structural organization analysis of the Pi-k(h) locus in both indica and japonica rice lines. A 100 kb region containing 50 kb upstream and 50 kb downstream sequences flanking to the Pi-k(h) locus was selected for the investigation. A total of 16 genes in indica and 15 genes in japonica were predicted and annotated in this region. The average GC content of indica and japonica genes in this region was 53.15% and 49.3%, respectively. Both indica and japonica sequences were polymorphic for simple sequence repeats having mono-, di-, tri-, tetra-, and pentanucleotides. Sequence analysis of the specific blast resistant Pi-k(h) allele of Tetep and the susceptible Pi-k(h) allele of the japonica rice line Nipponbare showed differences in the number and distribution of motifs involved in phosphorylation, resulting in the resistance phenotype in Tetep.
Trends in mortality among California physicians after giving up smoking: 1950-79.
Authors: J E Enstrom
Journal: BMJ (1983)

A study was conducted to assess how lung cancer and other mortality trends among California physicians had been influenced by the high proportion who had given up smoking since 1950. Several sample surveys indicated that the proportion of California physicians who currently smoked cigarettes had declined dramatically from about 53% in 1950 to about 10% in 1980. During the same period the proportion of other American men who smoked cigarettes had declined only modestly, from about 53% to 38%. Using the 1950 American Medical Directory a cohort of 10 130 California male physicians was established and followed up for mortality till the end of 1979, during which time 5090 died. The information from follow up and death certification was exceptionally good. The standardised mortality ratio for lung cancer among California male physicians relative to American white men declined from 62 in 1950-9 to 30 in 1970-9. The corresponding decline in standardised mortality ratio was from 100 to 63 for other smoking related cancer, from 106 to 71 for ischaemic heart disease, and from 62 to 35 for bronchitis, emphysema, and asthma. The standardised mortality ratio remained relatively constant for other causes of death not strongly related to smoking. The overall ratio declined in all age groups at a rate of about 1% a year. The total death rate among all physicians converged towards the rate among non-smoking physicians. By the end of the study period physicians had a cancer rate and total death rate similar to or less than those among typical United States non-smokers. This "natural experiment" shows that lung cancer became relatively less common on substantial elimination of the primary causal factor, cigarette smoking. Other smoking related diseases also became relatively less common, though factors other than cigarette smoking may have contributed to this change.