tbuckley/cabot-search huggingface dataset:
Cardiac Catheterization and Angiocardiography in Severe Neonatal Heart Disease
Authors: Grace S. Wolff
Journal: JAMA (1975)

The book is addressed to the neophyte cardiologist who faces the neonate with heart disease. As such, it provides a concise, workable approach to the clinical and laboratory diagnosis and treatment of the sick infant. There is an unavoidable pseudosimplicity that the authors readily acknowledge, for it would be impossible to encompass all of the intricacies of this most dynamic area of congenital heart disease. There are no pretensions at providing a comprehensive, intensive study, but helpful methodological proposals are offered for each part of the hazardous lifedrama of cardiac catheterization in the newborn. The book is divided into three major sections concerned with the activities before, during, and after cardiac catheterization. The first section deals with the clinical diagnosis and the decision to undertake the catheterization. The second and most valuable section is concerned with the performance of the procedure. The authors stress the importance of segregation of the
Germany, the G7, and global health
Authors: G. Yamey, S. Campe, S. Fewer
Journal: BMJ (2015)

Health systems, new tools, and delivery science should top the agenda

Remember global health? It had a fantastic 10 years from 2002-12—the “golden decade” of rising health aid1—but is now slipping down the international agenda. Some development experts argue that other sectors, such as agriculture, should “take centre stage.”2 This is misguided. Health investment is the largest contributor to sustainable development.3 And a retreat from health would threaten the impressive gains of the past decade in reducing infectious disease, maternal, and child mortality.4

Fortunately, there are some promising signs that Germany, this year’s chair of the G7 group of large advanced economies, may spend some of its political capital on pushing health back up the global agenda. It got off to a strong start, hosting a conference in Berlin in January at which donors pledged $7.5bn (£4.9bn; €6.7bn) to Gavi, the vaccine alliance, an amount that exceeded expectations and that could fund immunisations for an additional 300 million children.5 It has identified three global health priorities for the G7 in 2015: neglected tropical diseases, pandemics, and antimicrobial resistance.6 What should we make of these priorities, and does the G7 really have the clout to effect global change?

There is always plenty of fanfare—and scepticism—surrounding G7 summits, and the same will surely be the …
THE SEPARATION OF SERUM INTO COAGULATIVE AND NON-COAGULATIVE FRACTIONS
Authors: Alfred F. Hess
Journal: The Journal of Experimental Medicine (1916)

The fact that the coagulative principle is closely associated with the euglobulin fraction of the blood is of clinical as well as of theoretical interest. It enables us to prepare a hemostatic containing about 2 per cent of protein which is more potent than the whole serum containing 6 to 7 per cent of protein. A preparation of this kind has been made in this laboratory from horse serum and employed during the past few months in numerous cases of bleeding. This euglobulin is absolutely sterile, as it has been passed through a Berkefeld filter, and is safeguarded against decomposition by the addition of 0.3 per cent tricresol. A detailed account of the therapeutic use of euglobulin will be reported elsewhere. It may be stated, however, that it has been employed in the various manifestations of intractable hemorrhage in which horse serum has been so largely resorted to of late years, and that in certain cases has seemed to bring about most satisfactory results; in no instance has there been any untoward effect. When intravenous injections are resorted to, euglobulin seems to be preferable to serum which contains fully three times the quantity of protein. It also seems to be absorbed more quickly from the subcutaneous tissues. In all probability it will be found to meet the same indications as whole serum, possessing the advantages of concentration, and necessitating the introduction into the body of a much smaller amount of foreign protein.
Replacement of angiotensin converting enzyme inhibition by carvedilol results in long-term reversed left ventricular remodeling in mild heart failure and is well tolerated: Results of the CARMEN (Carvedilol aceinhibitor remodeling in mild heart failure evaluation) study
Authors: Willem J. Remme, Jordi Soler-Soler, Lars Ryden, Per Hildebrandt, Marco Bobbio, Wybren Jaarsma, Michel Komajda, Armin Scherhag, Guenther Riegger
Journal: Journal of the American College of Cardiology (2003)
Methotrexate for intractable benign familial chronic pemphigus
Authors: G.M. Fairris, J.E. White, B.J. Leppard, P.G. Goodwin
Journal: British Journal of Dermatology (1986)

Journal Article Methotrexate for intractable benign familial chronic pemphigus Get access G.M. Fairris, G.M. Fairris Department of Dermatology, Royal South Hants Hospital, Graham Road, Southampton, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.E. White, J.E. White Department of Dermatology, Royal South Hants Hospital, Graham Road, Southampton, U.K. Search for other works by this author on: Oxford Academic Google Scholar B.J. Leppard, B.J. Leppard Department of Dermatology, Royal South Hants Hospital, Graham Road, Southampton, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.G. Goodwin P.G. Goodwin Department of Dermatology, Royal South Hants Hospital, Graham Road, Southampton, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 5, 1 November 1986, Page 640, https://doi.org/10.1111/j.1365-2133.1986.tb05780.x Published: 01 November 1986
Ninth Annual Report of the National Intern Matching Program
Authors: Ward Darley
Journal: JAMA (1961)

THE NINTH National Intern Matching Program (NIMP) was completed without incident except that in many instances bad weather delayed the mail delivery of both student and hospitalmatching notifications.  This report, as shown by Tables 1, 2, 3, 4, and 5, brings most of the usual basic data up to date. Table 1, which depicts the numerical and percentage participation of United States and Canadian graduates and approved United States hospitalsand programs, shows no significant changes between 1960 and the previous 5 years. Except for the continued increases in the number of intern positions offered and students participating, Table 2 likewise shows no significant change over previous years. However, so as to give clarification to the significance of the group of graduates that go unmatched, 2 new columns (the last 2) have been added to this table. From the figures shown in these 2 columns, it is seen that, by
Ecologic regression analysis and the study of the influence of air quality on mortality.
Authors: S Selvin, D Merrill, L Wong, S T Sacks
Journal: Environmental Health Perspectives (1984)

This presentation focuses entirely on the use and evaluation of regression analysis applied to ecologic data as a method to study the effects of ambient air pollution on mortality rates. Using extensive national data on mortality, air quality and socio-economic status regression analyses are used to study the influence of air quality on mortality. The analytic methods and data are selected in such a way that direct comparisons can be made with other ecologic regression studies of mortality and air quality. Analyses are performed by use of two types of geographic areas, age-specific mortality of both males and females and three pollutants (total suspended particulates, sulfur dioxide and nitrogen dioxide). The overall results indicate no persuasive evidence exists of a link between air quality and general mortality levels. Additionally, a lack of consistency between the present results and previous published work is noted. Overall, it is concluded that linear regression analysis applied to nationally collected ecologic data cannot be used to usefully infer a causal relationship between air quality and mortality which is in direct contradiction to other major published studies.
Myocardial tissue recruitment in the dog as determined by double tracer dilution method.
Authors: A L'Abbate, R R Mildenberger, D T Zborowska-Sluis, G A Klassen
Journal: Circulation Research (1976)

The amount of tissue perfused, as determined from the difference in volume of distribution between a diffusible indicator (125I-antipyrine) and an intravascular indicator (131 I-albumin) was measured at different values of coronary flow, perfusion pressure, and vasomotor tone in the working left ventricle of an open-chest dog. Coronary pressure and flow were regulated independently from the systemic circulation and coronary vasomotor tone was reduced by dipyridamole. At each flow vasomotor tone was assessed by using as a reference the maximal vasodilation induced by arrest of flow. Measured tissue space was considered to be related to the capillary surface area available for tracer diffusion and therefore to the number of perfused capillaries per volume of muscle. A relationship between coronary blood flow and tissue volume was observed. It was found to be independent of vasomotor tone. Vasodilation was found to increase available exchanging capillary surface at a constant perfusion pressure.
Head lice can be controlled without application of insecticide lotions
Authors: G. Lewendon
Journal: BMJ (1999)

EDITOR—Dawes et al's evidence based case report about treatment for head lice was interesting as an exercise in evidence searching, but the authors failed to ask the right question in the first place.1 A more useful research question would have been, “In children attending primary care with head lice, what is the most effective …
Handbook of Obesity Prevention: A Resource for Health Professionals
Authors: Ann F. La Berge
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Take Me to the Green Valley
Authors: Maureen Tolman Flannery
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of PTEN Tumor Suppressor Promotes the Generation of Induced Pluripotent Stem Cells
Authors: Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Naoki Takeda, Chika Sakamoto, Hirotaka Kawano, Takenobu Nii, Shohei Miyamoto, Yoko Nagai, Michiyo Okada, Hiroyuki Inoue, Kohichi Kawahara, Akira Suzuki, Yoshie Miura, Kenzaburo Tani
Journal: Molecular Therapy (2013)

Induced pluripotent stem cells (iPSCs) can be generated from patients with specific diseases by the transduction of reprogramming factors and can be useful as a cell source for cell transplantation therapy for various diseases with impaired organs. However, the low efficiency of iPSC derived from somatic cells (0.01-0.1%) is one of the major problems in the field. The phosphoinositide 3-kinase (PI3K) pathway is thought to be important for self-renewal, proliferation, and maintenance of embryonic stem cells (ESCs), but the contribution of this pathway or its well-known negative regulator, phosphatase, and tensin homolog deleted on chromosome ten (Pten), to somatic cell reprogramming remains largely unknown. Here, we show that activation of the PI3K pathway by the Pten inhibitor, dipotassium bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate, improves the efficiency of germline-competent iPSC derivation from mouse somatic cells. This simple method provides a new approach for efficient generation of iPSCs.
Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America
Authors: Sukhbir Ahluwalia, Stephen D Lawn, Jeevendra Kanagalingam, Henry Grant, Diana N J Lockwood
Journal: BMJ (2004)

Despite the setbacks successes have been achieved.Of the 18 SCID patients treated for their life threatening condition, 17 are still alive and have had a healthy, functioning immune system for up to five years and a good quality of life.In addition to monogenic conditions, gene therapy also represents a viable treatment for multigenic disorders, such as cancer, either as a standalone treatment or in combination with chemotherapy or radiotherapy.A huge amount of work is yet to be done, but with efficient monitoring of trials and continuous improvements of viral vectors, gene therapy may still represent an important addition to the treatment armamentarium for a range of diseases.
Acid Phosphatase Tests as Evidence of Rape
Authors: Russell S. Fisher
Journal: New England Journal of Medicine (1949)

ACID PHOSPHATASE TESTS AS EVIDENCE OF RAPEThe family physician is usually the first person called when aid or advice is sought by the victim of a sexual assault. His duties in such cases include both the care of the patient and the accumulation of evidence likely to be of value in establishing identity or guilt of the assailant. The evidence is twofold: that of physical violence suffered by the victim, as shown by bruises, scratches, or other injuries of her body, and evidence of ejaculate on or about her body. Since rape of a child or woman not under . . .
Double-Edged Role of the CXCL12/CXCR4 Axis in Experimental Myocardial Infarction
Authors: Elisa A. Liehn, Nancy Tuchscheerer, Isabella Kanzler, Maik Drechsler, Line Fraemohs, Alexander Schuh, Rory R. Koenen, Simone Zander, Oliver Soehnlein, Mihail Hristov, Gabriela Grigorescu, Andreea O. Urs, Mircea Leabu, Ilie Bucur, Marc W. Merx, Alma Zernecke, Josef Ehling, Felix Gremse, Twan Lammers, Fabian Kiessling, Jürgen Bernhagen, Andreas Schober, Christian Weber
Journal: Journal of the American College of Cardiology (2011)
Defective fat storage
Authors: Ruth Williams
Journal: The Journal of Experimental Medicine (2006)

o r > r u t h .w i l l i a m s @ r o c k e f e l l e r .e d u < / c o r > Creating the right environment Like baby chicks, stem cells need a nest-a niche within the body where they reside and self-renew.Oguro et al. (page < A r t R e f v o l = " 2 0 3 " I s s = " 1 0 " > 2247< / A r t R e f > ) find that, for blood stem cells, this nest is built by the same gene silencer that also helps them self-renew.This silencer is Bmi1, which turns off two cell cycle inhibitor genes, Ink4a and Arf, to promote the self-renewal of hematopoietic stem cells (HSCs).Oguro et al. showed that defective HSC self-renewal in Bmi1deficient mice can be restored by deletion of these cell cycle regulators, as previously observed in neural stem cells.But the new results show that HSC levels gradually decline as these mice age.The authors wondered whether the progressive HSC problem might be due to defects in the HSC niche-the bone marrow microenvironment.Indeed, they found that development of the spongy meshwork structure of bone marrow in mice lacking Bmi1 was severely impaired and failed to support renewal of wild-type HSCs.The defects suggested that Bmi1 might be required for normal growth of the niche cells.The group showed that the proliferation of boneforming osteoblasts was impaired in the absence of Bmi1.These findings fit well with previous reports that osteoblasts are important components of the HSC niche.The defective niche was not rescued by deletion of Ink4a and Arf.Nest building in the bone marrow is therefore likely to require silencing of other Bmi1 targets.The team is currently searching for what those targets might be.
Continuous and intermittent itraconazole dosing schedules for the treatment of onychomycosis: a pharmacokinetic comparison
Authors: None HAVU, None BRANDT, None HEIKKILÄ, None HOLLMEN, None OKSMAN, None RANTANEN, None SAARI, None STUBB, None TURJANMAA, None PIEPPONEN
Journal: British Journal of Dermatology (1999)

This multicentre, double-blind, randomized study compared the pharmacokinetics of itraconazole given at 200 mg once daily for 3 months and intermittently at 200 mg twice daily for 1 week per month followed by a 3-week drug-free period for 3 months in the treatment of onychomycosis. Patients were followed for 9 months after treatment. Itraconazole and hydroxy-itraconazole plasma concentrations and itraconazole nail tip concentrations were determined at regular intervals. With intermittent therapy (n = 64), increases of consistent magnitude were seen in the mean itraconazole and hydroxy-itraconazole plasma concentrations at the end of each 1-week treatment phase; values returned towards baseline during each subsequent 3-week drug-free period. The mean concentration of itraconazole in fingernail tips increased steadily from week 4, reached a maximum value at week 24 (213 ng/g), declined sharply between weeks 24 and 36 and returned to baseline by week 48; the mean concentration profile was similar for toenail tips (maximum value 305 ng/g at week 24) but decreased at a slower rate. With continuous therapy (n = 65), steady-state mean plasma concentrations of itraconazole and hydroxy-itraconazole were obtained within 4-5 weeks of the start of treatment and remained reasonably constant between weeks 4 and 12. The mean concentration of itraconazole in fingernail tips reached a maximum value at week 12 (524 ng/g) and returned towards baseline by week 48; in contrast, the maximum mean concentration of itraconazole in toenail tips was 698 ng/g at week 36 and did not return to baseline by week 48. No clear relationship was observed between response to treatment and concentration of itraconazole or hydroxy-itraconazole in plasma or itraconazole in nails, suggesting that concentrations exceeded therapeutic levels. In conclusion, intermittent therapy resulted in higher maximum itraconazole plasma concentrations but lower total drug exposure, and hence lower itraconazole nail concentrations, than continuous therapy. However, the intermittent schedule was not associated with a lower cure rate, which indicates that itraconazole nail concentrations remained within the therapeutic range.
THE STUDY OF THE EFFICACY OF SOME AGENTS USED FOR THE PROTECTION OF THE SKIN FROM EXPOSURE TO LIGHT
Authors: T. M. MACLEOD, W. FRAIN-BELL
Journal: British Journal of Dermatology (1971)

Journal Article THE STUDY OF THE EFFICACY OF SOME AGENTS USED FOR THE PROTECTION OF THE SKIN FROM EXPOSURE TO LIGHT Get access T. M. MACLEOD, T. M. MACLEOD Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar W. FRAIN‐BELL W. FRAIN‐BELL Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 3, 1 March 1971, Pages 266–281, https://doi.org/10.1111/j.1365-2133.1971.tb14217.x Published: 01 March 1971 Article history Accepted: 30 October 1970 Published: 01 March 1971
Noninvasive Mechanical Ventilation in the Weaning of Patients with Respiratory Failure Due to Chronic Obstructive Pulmonary Disease
Authors: Stefano Nava
Journal: Annals of Internal Medicine (1998)

Background: In patients with acute exacerbations of chronic obstructive pulmonary disease, mechanical ventilation is often needed. The rate of weaning failure is high in these patients, and prolonged mechanical ventilation increases intubation-associated complications. Objective: To determine whether noninvasive ventilation improves the outcome of weaning from invasive mechanical ventilation. Design: Multicenter, randomized trial. Setting: Three respiratory intensive care units. Patients: Intubated patients with chronic obstructive pulmonary disease and acute hypercapnic respiratory failure. Intervention: A T-piece weaning trial was attempted 48 hours after intubation. If this failed, two methods of weaning were compared: 1) extubation and application of noninvasive pressure support ventilation by face mask and 2) invasive pressure support ventilation by an endotracheal tube. Measurements: Arterial blood gases, duration of mechanical ventilation, time in the intensive care unit, occurrence of nosocomial pneumonia, and survival at 60 days. Results: At admission, all patients had severe hypercapnic respiratory failure (mean pH, 7.18 ± 0.06; mean Paco 2, 94.2 ± 24.2 mm Hg), sensory impairment, and similar clinical characteristics. At 60 days, 22 of 25 patients (88%) who were ventilated noninvasively were successfully weaned compared with 17 of 25 patients (68%) who were ventilated invasively. The mean duration of mechanical ventilation was 16.6 ± 11.8 days for the invasive ventilation group and 10.2 ± 6.8 days for the noninvasive ventilation group (P = 0.021). Among patients who received noninvasive ventilation, the probability of survival and weaning during ventilation was higher (P = 0.002) and time in the intensive care unit was shorter (15.1 ± 5.4 days compared with 24.0 ± 13.7 days for patients who received invasive ventilation; P = 0.005). Survival rates at 60 days differed (92% for patients who received noninvasive ventilation and 72% for patients who received invasive ventilation; P = 0.009). None of the patients weaned noninvasively developed nosocomial pneumonia, whereas 7 patients weaned invasively did. Conclusions: Noninvasive pressure support ventilation during weaning reduces weaning time, shortens the time in the intensive care unit, decreases the incidence of nosocomial pneumonia, and improves 60-day survival rates.