Late Clonal Complications in Older Patients Receiving Immunosuppressive Therapy for Aplastic Anemia
Authors: Masahiro Kami, Utako Machida, Hisamaru Hirai
Journal: Annals of Internal Medicine (1999)

Letters19 October 1999Late Clonal Complications in Older Patients Receiving Immunosuppressive Therapy for Aplastic AnemiaMasahiro Kami, MD, Utako Machida, MD, and Hisamaru Hirai, MDMasahiro Kami, MDUniversity of Tokyo; Tokyo 113-8655, Japan (Kami)University of Tokyo; Tokyo 113-8655, Japan (Machida)University of Tokyo; Tokyo 113-8655, Japan (Hirai)Search for more papers by this author, Utako Machida, MDUniversity of Tokyo; Tokyo 113-8655, Japan (Kami)University of Tokyo; Tokyo 113-8655, Japan (Machida)University of Tokyo; Tokyo 113-8655, Japan (Hirai)Search for more papers by this author, and Hisamaru Hirai, MDUniversity of Tokyo; Tokyo 113-8655, Japan (Kami)University of Tokyo; Tokyo 113-8655, Japan (Machida)University of Tokyo; Tokyo 113-8655, Japan (Hirai)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Tichelli and colleagues (1) reported that intensive immunosuppression is effective for the treatment of aplastic anemia in elderly patients. They provided important information on the management of these patients, but we have some concerns about the development of late clonal complications. These complications occurred in 9 of 127 patients older than 60 years of age (7.1%). In addition, there were six solid tumors and three hematologic complications in this study.Malignant hematologic conditions were observed in 2.3% of the oldest age group in Tichelli and colleagues' study, but this incidence was much lower than that in the ...References1. Tichelli A, Socié G, Henry-Amar M, Marsh J, Passweg J, Schrezenmeier H, et al . Effectiveness of immunosuppressive therapy in older patients with aplastic anemia. Ann Intern Med. 1999;130:193-201. LinkGoogle Scholar2. Tichelli A, Gratwohl A, Nissen C, Speck B. Late clonal complications in severe aplastic anemia. Leuk Lymphoma. 1994;12:167-75. CrossrefMedlineGoogle Scholar3. Doney K, Leisenring W, Storb R, Appelbaum FR. Primary treatment of acquired aplastic anemia: outcomes with bone marrow transplantation and immunosuppressive therapy. Ann Intern Med. 1997;126:107-15. LinkGoogle Scholar4. Socié G, Henry-Amar M, Bacigalupo A, Hows J, Tichelli A, Ljungman P, et al . Malignant tumors occurring after treatment of aplastic anemia. N Engl J Med. 1993;329:1152-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Tokyo; Tokyo 113-8655, Japan (Kami)University of Tokyo; Tokyo 113-8655, Japan (Machida)University of Tokyo; Tokyo 113-8655, Japan (Hirai) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffectiveness of Immunosuppressive Therapy in Older Patients with Aplastic Anemia André Tichelli , Gérard Socié , Michel Henry-Amar , Judith Marsh , Jakob Passweg , Hubert Schrezenmeier , Shaun McCann , Jill Hows , Per Ljungman , Pedro Marin , Aruna Raghavachar , Anna Locasciulli , Alois Gratwohl , Andrea Bacigalupo , and Metrics Cited byAplasies médullaires acquisesAplasies médullaires acquisesAplasies médullaires acquises 19 October 1999Volume 131, Issue 8Page: 633KeywordsAge groupsAplastic anemiaElderlyImmunosuppressivesSafety ePublished: 15 August 2000 Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...