tbuckley/cabot-search huggingface dataset:
Determination of ectoenzyme activities in leukemic cells and in established hematopoietic cell lines
Authors: Andreas Morell, Gabriele Losa, Stephan Carrel, Didier Heumann, Vladimir E. Von Fliedner
Journal: American Journal of Hematology (1986)

Abstract Ectoenzyme activities were determined in peripheral blood cells from patients with acute leukemias, from normal controls, and in cells of hematopoietic cell lines. In common acute lymphoblastic leukemia, cell membrane‐associated 5′‐nucleotidase (5′‐N) activity was significantly higher than in acute T and unclassified lymphoblastic leukemias. In acute myeloblastic and myelomonocytic leukemias, cells contained significantly higher γ‐glutamyl transpeptidase (γ‐GT) activity than in lymphoblastic leukemias. Normal B lymphocytes differed from T cells and monocytes mainly in their 5′N activity, whereas in monocytes, γ‐GT activity was more pronounced than in other normal blood cells. Hematopoietic cell lines showed some distinct patterns of ectoenzyme activity. Most B cell lines had high 5′N and (Na‐K‐Mg) adenosine triphosphatase activities. In lines of myeloid origin, elevated γ‐GT values were found. In lymphoid stem cells and in T lymphoblast lines, most ectoenzyme activities were lower than in the other cell lines. In some cell lines, characteristic high‐activity marker enzymes were detected.
Colon and Rectal Surgeons Are Trying Botox Treatment, Too
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta
Authors: Ingo Grafe, Tao Yang, Stefanie Alexander, Erica P Homan, Caressa Lietman, Ming Ming Jiang, Terry Bertin, Elda Munivez, Yuqing Chen, Brian Dawson, Yoshihiro Ishikawa, Mary Ann Weis, T Kuber Sampath, Catherine Ambrose, David Eyre, Hans Peter Bächinger, Brendan Lee
Journal: Nature Medicine (2014)
The immediate pressor response to saralasin in man: a test of angiotensin II receptor vacancy.
Authors: J M Wallace, D B Case, J H Laragh, H J Keim, J I Drayer, J E Sealey
Journal: Circulation Research (1979)

Saralasin, 10 microgram/kg per min, caused an immediate rise in blood pressure in 52 of 57 (91.2%) hypertensive patients. The increase in diastolic pressure averaged 18.8 +/- 1.83 mm Hg (mean +/- SE) in normal renin patients on a normal salt intake. This immediate pressor response was absent in only five high renin patients and, conversely, was very large in three low renin patients. Direct arterial recordings are necessary to define the response accurately; it begins in 60--90 seconds, peaks in amplitude at 2.05 +/- 0.38 minutes, and subsides over the next 5 minutes in normal renin and high renin patients. The blood pressure elevation is inversely related to background plasma renin activity (r = -0.66, P less than 0.001), and also is directly, but weakly, related to 24-hour urinary sodium excretion (r = + 0.29). Therefore, the amplitude of the elevation is predictably diminished by the rise in plasma renin consequent to prior sodium restriction, and also by preliminary receptor exposure to low dose nonpressor infusions of saralasin itself (0.01-0.1 microgram/kg per min). Phentolamine had no effect on the response in two patients. We propose that the immediate pressor response to saralasin is related directly to the preexisting degree of vacancy of angiotensin II vascular receptors and that the initial agonistic action of the drug may prove useful in defining the angiotensin II receptor status in hypertensive diseases.
Paradoxical Motion of Interventricular Septum in Left Bundle Branch Block
Authors: ABDUL S. ABBASI, LESLIE M. EBER, REX N. MACALPIN, ALBERT A. KATTUS
Journal: Circulation (1974)

Abnormal interventricular septal motion, with pre-ejection posterior motion and anterior motion away from the posterior left ventricular wall during ejection, was demonstrated by echocardiography in 14 out of 17 cases with complete left bundle branch block (LBBB). Two of 14 cases had intermittent LBBB and showed abnormal septal motion only during LBBB. Of the control group of 49 patients without LBBB but with cardiac disorders similar to the cases with LBBB, only two showed abnormal septal motion. However, pre-ejection motion was not seen in these two cases. During right ventricular pacing abnormal septal motion was observed in three out of ten cases. It is suggested that conduction abnormalities are responsible for abnormal septal motion in LBBB; normal septal motion in most cases with right ventricular pacing may be due to different conduction pathways not affecting the septum.
Psychiatric Illness of the Puerperium
Authors: B. M. N. Pitt
Journal: BMJ (1964)

BRITiSHIn labour a large foetal head deep in the pelvic cavity may produce a ring of pressure on the lower segment or cervix resulting in ischaemia.The tearing force is provided by early expulsive efforts on the part of the mother.The ischaemic ring interferes with the mechanism of dilatation, but the cervix itself plays an entirely passive role, merely reflecting a functional failure at a higher level.The case presented would support this hypothesis in many respects.Labour was pro- longed, the cervix dilated to three fingers, the head was engaged, and forceps delivery of a very large baby (over 10 lb.-4.5 kg.) was
Effect of repeated sputum induction on cell counts in normal volunteers.
Authors: J A Nightingale, D F Rogers, P J Barnes
Journal: Thorax (1998)

BACKGROUND: Sputum induction is becoming more commonly used to assess airway inflammation. Since it is a relatively non-invasive procedure it may be useful for repeated measurements over a short period of time. METHODS: To assess the repeatability of the method over a 24 hour period, eight healthy, non-smoking, non-atopic subjects (four men) of mean age 30 years underwent sputum induction, repeated at eight hours and 24 hours. Sputum was induced by inhalation of 3.5% saline. Absolute and differential counts of inflammatory cells were performed on the whole sputum after dilution in Hank's balanced salt solution containing 1% dithiothreitol to solubilise the mucus content of the samples. RESULTS: There was a significant rise in the percentage of neutrophils in the eight hour sample compared with the baseline (57%, range 25-94% at eight hours compared with 28%, range 19-60%: median difference 26%). The median baseline percentage of macrophages was 55% (range 26-69%) which fell to 38% (range 3-56%: median difference 22%) at eight hours and 19% (range 14-59%: median difference 25%) at 24 hours. There was no significant change in the differential counts of eosinophils, lymphocytes or columnar epithelial cells, nor in any of the absolute cell counts, at any time point. CONCLUSIONS: Sputum induction may have limited utility in serial assessment of neutrophilic airway inflammation in normal subjects within a 24 hour period.
CELLS AS ANTIGEN CARRIERS AND AS IMMUNOGLOBULIN PRODUCERS
Authors: Chi-Tao Chou, S. Dubiski, Bernhard Cinader
Journal: The Journal of Experimental Medicine (1967)

The injection into newborn rabbits of a small quantity of human albumin, associated with red blood corpuscles or nucleated rabbit cells, induces an antibody response in the majority of animals, whereas the same quantity of antigen in solution fails to stimulate antibody formation or induces tolerance. The promoting capacity of the cells depends on attachment of antigen to them. The antibody produced after the injection of albumin, associated with nucleated cells, is of recipient origin. However, immunoglobulin carrying the marker of donor cells can be demonstrated in the recipient animals, and may reach serum concentrations similar to those normally present in animals which are heterozygous with respect to the marker. It appears that the antibody-promoting function and the synthetic capacity for allotype are quite distinct and that the period required for allotype formation is very short with mononuclear peritoneal exudate cells and is very much longer with cells from the thymus. The capacity of cells from lymph nodes for sustained allotype formation is less than that of thymus cells but greater than that of mononuclear peritoneal exudate cells.
Applied Physiology of Respiratory Care
Authors: Robert M. Senior
Journal: JAMA (1977)

In recent years respiratory care has played a key role in the management of patients who are critically ill from whatever cause. This volume is an outstanding, sophisticated compilation of information relevant to respiratory care. The volume is divided into six sections. The first, on general management of respiratory failure, contains material on diverse topics such as the effects of controlled ventilation on the performance of several organ systems, the effects of infection on respiratory function, fluid balance, and nutrition, and problems in monitoring. Virtually every physician involved in respiratory care will gain by reading this section. The other sections of the book, equally valuable, cover specific surgical problems, trauma, respiratory failure complicating organ (heart, liver, renal, nervous system) failure, effects of age and obesity, and miscellaneous problems such as poisoning and extracorporeal membrane oxygenation. Sorting the subject matter into these categories reflects a sound way of grouping respiratory care
885-3 Correlation between the extent of diseased vessels and the incidence of in-hospital cardiac mortality in acute myocardial infarction
Authors: Yasuhiro Ishii, Hiroshi Kasanuki, Masahiro Yagi, Jun-ichi Yamaguchi, Michitaka Nagashima, Hiroshi Ogawa, Tetsuya Sumiyoshi, Takashi Honda, Kazuo Haze, Toshinobu Horie
Journal: Journal of the American College of Cardiology (2004)
Successful Surgical Repair of Aortic Insufficiency Due to Valvular Fenestration
Authors: C. P. BAILEY, ALBERT N. BREST, NICOLAS DONTAS, J. F. URICCHIO
Journal: Circulation (1959)

A case of dynamic aortic insufficiency due to valvular fenestration is described. The defect was successfully repaired with an Ivalon patch to close the fenestration plus the surgical creation of a bicuspid aortic valve.
Community health doctors left out
Authors: H. Gordon
Journal: BMJ (1993)

Two drugs are better than one EDITOR,-We disagree with some of D E Price's views on managing erectile dysfunction in diabetes.'The erectile dysfunction is not always organic in origin since psychogenic factors based on anxiety are as common in diabetic patients as in the general population.A total lack of erections under all circumstances, including during sleep and on waking, may indeed be due to neurogenic impotence, but patients with this are a minority.Patients more commonly complain of a partial erection during sexual activity, which suggests a vasculogenic rather than a neurogenic cause.Intracavernous injection of a vasoactive agent is a simple means of distinguishing vasculogenic from psychogenic and neurogenic impotence.More sophisticated investigations are rarely neces- sary except to investigate the possibility of occult neurological problems or of arterial disease worth treating surgically-that is, in young non-smoking men under 40 who do not have diabetes or hypertension.The use of intracavernous agents for erectile dysfunction has indeed revolutionised the management of this problem, but, at least in theory, papaverine should not now be used alone because of the occurrence of penile fibrosis and priapism.The incidence of these complications is diminished by the addition of phentolamine, but prostaglandin E1 is safer, although a suitable formulation for general use is not yet available.
Exacerbation of Multiple Sclerosis After the Administration of Recombinant Human Interferon Alfa
Authors: Dominique Larrey
Journal: JAMA (1989)

To the Editor.—  Interferons appear to have varying effects on multiple sclerosis according to their major types, designated as alfa, beta, or gamma. The administration of interferon alfa for systemic effect 1 and the intrathecal administration of interferon beta 2 have been reported to reduce the frequency and severity of exacerbations of multiple sclerosis, possibly because of antiviral properties. In contrast, the disease is exacerbated by administration of interferon gamma, hypothetically because this compound may potentiate immune response. 3   Contrary to a previous report, 1 we observed a patient in whom acute exacerbation of multiple sclerosis developed after he received interferon alfa (interferon alfa-2b [Intron A]) for chronic active non-A, non-B hepatitis.  Report of a Case.—  A 38-year-old man was included in a clinical trial assessing the effect of interferon alfa on chronic active non-A, non-B hepatitis in March 1988. The patient had been suffering from multiple sclerosis since 1976.
What caused the winter crisis in the NHS?
Authors: R. Woodman
Journal: BMJ (1999)

Low uptake of influenza vaccine, a shortage of nurses, unrealistic expectations of patients, an already high occupancy rate for beds, and the unfortunate timing of outbreaks of both influenza and meningitis over the new year holiday brought the NHS to its knees last week.

The Public Health Labora-tory Service warned last year that vaccine uptake in 1996-7was only 44% among elderly patients and only 12.4% among younger patients at risk. It said that there was a “clear need” to increase uptake, particularly among vulnerable people under 65.

Sir Kenneth Calman, the chief medical officer, wrote to all doctors in August 1998and launched a “flu awareness week” in October to publicise the new policy of offering vaccinations …
Hepatic bile salt flux does not modulate level and activity of the sinusoidal Na+-taurocholate cotransporter (ntcp) in rats
Authors: Nynke R. Koopen, Henk Wolters, Michael Müller, Ingrid J. Schippers, Rick Havinga, Han Roelofsen, Roel J. Vonk, Bruno Stieger, Peter J. Meier, Folkert Kuipers
Journal: Journal of Hepatology (1997)
PROGNOSTIC ROLE OF MULTIDETECTOR COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY IN PATIENTS WITH SUSPECTED CORONARY ARTERY DISEASE
Authors: Hikmet Yorgun, Uğur Canpolat, Kudret Aytemir, Ergün B. Kaya, Tuncay Hazlrolan, Lale Tokgözoğlu, Giray Kabakçl, Hamza Sunman, Edis Demiri, Muhammet Dural, Ali Taher, Ahmet H. Ateş, Ayşegül Ülgen, Mehmet A. Şendur, Hilmi Özkutlu, Ali Oto
Journal: Journal of the American College of Cardiology (2011)
Abuse of Medical Students
Authors: Donna M. White
Journal: JAMA (1982)

To the Editor.—  I am writing in response to the article by Dr Silver. As a 1977 medical school graduate and as a survivor of internship, I think that I can, unequivocally, agree that medical student abuse does exist. From my experiences I believe that it is alive and well not only in medical school but also in internship.  I believe, however, that not all medical students and interns are abused or at least not to equal extent. For a woman it is much more difficult to find a mentor or a  parent within the training setting who will truly foster her feelings of competence and confidence as a physician, much less feelings of family membership instead of second-class citizenship. I am sure that women are not exclusive objects of medical student-intern abuse, but this is one group that is, in my experience, at risk.  I struggled with the
Vision 1 Year after Gene Therapy for Leber's Congenital Amaurosis
Authors: Artur V. Cideciyan, William W. Hauswirth, Tomas S. Aleman, Shalesh Kaushal, Sharon B. Schwartz, Sanford L. Boye, Elizabeth A.M. Windsor, Thomas J. Conlon, Alexander Sumaroka, Alejandro J. Roman, Barry J. Byrne, Samuel G. Jacobson
Journal: New England Journal of Medicine (2009)

To the Editor: Leber's congenital amaurosis, a common cause of blindness in infants and children,1 recently became the first human genetic retinal disease to show improved vision in response to tre...
A Phase II Study of Paclitaxel + Etoposide + Cisplatin + Concurrent Radiation Therapy for Previously Untreated Limited Stage Small Cell Lung Cancer (E2596): A Trial of the Eastern Cooperative Oncology Group
Authors: Leora Horn, Patricia Bernardo, Alan Sandler, Henry Wagner, Nathan Levitan, Mark L. Levitt, David H. Johnson
Journal: Journal of Thoracic Oncology (2009)
Coxsackie virus heart diseases.
Authors: M. Longson
Journal: BMJ (1968)

MEDICAL OPLmeal were, of course, entirely normal and his haemoglobin concentration never decreased.In Birmingham as in Liverpool he claimed to be a game warden in the Kruger National Park in Rhodesia.His description of elephants in a particular region was however noted to be erroneous by an even more ingenious house physician who had recently visited this part of Rhodesia.The patient realized that he had been exposed, and on the seventh day after admission hastily dis- charged himself from hospital.He claimed to be moving northwards to relatives.
Elevated IL-17 produced by Th17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma
Authors: Rao H. Prabhala, Dheeraj Pelluru, Mariateresa Fulciniti, Harsha K. Prabhala, Puru Nanjappa, Weihua Song, Christine Pai, Samir Amin, Yu-Tzu Tai, Paul G. Richardson, Irene M. Ghobrial, Steven P. Treon, John F. Daley, Kenneth C. Anderson, Jeffery L. Kutok, Nikhil C. Munshi
Journal: Blood (2010)
Prevalence and incidence of the diagnosis of gout in Great Britain.
Authors: W J Currie
Journal: Annals of the Rheumatic Diseases (1979)

A study in gout of the incidence of diagnosis from 1971 to 1975 and of the prevalence at 31 December 1975 was carried out in a representative general practice sample comprising 64 practices and a population numbering 1 in 145 of the total population of Great Britain. The results show an annual incidence in Great Britain from 1971 to 1975 varying from 0.25 to 0.35 per 1000 and an overall prevalence at 31 December 1975 of 2.6 per 1000. The prevalence in England was found to be significantly greater than in the rest of Great Britain and that in Wales to be significantly greater than in Scotland. In 10% of the cases the gout was believed to be secondary, with induction by diuretics being the most frequent cause. The prevalence of primary gout was estimated to be 2.3 per 1000.
MRI VENOUS VOLUME MEASUREMENTS IN PERIPHERAL ARTERIAL DISEASE: A PILOT STUDY FROM THE EFFECT OF LIPID MODIFICATION ON PERIPHERAL ARTERIAL DISEASE AFTER ENDOVASCULAR INTERVENTION (ELIMIT) STUDY
Authors: Smita Negi, Gerd Brunner, Anirudh Kumar, Eric Y. Yang, Tyler Murray, Husam Athamneh, Justin T. Saunders, Dipan J. Shah, Carlos Bechara, Peter H. Lin, Changyi Chen, Alan B. Lumsden, Salim S. Virani, Vijay Nambi, Christie M. Ballantyne, Joel D. Morrisett
Journal: Journal of the American College of Cardiology (2011)
THE INFLUENCE OF X-RAY LESIONS OF THE INTESTINAL MUCOSA ON ABSORPTION OF GLUCOSE AND OTHER SUGARS
Authors: K. W. Buchwald
Journal: The Journal of Experimental Medicine (1931)

A sublethal dose of x-rays was applied over the abdomen of rats and over the thorax for control purposes. 20 and 40 hours after radiation (i.e. during the "latent period") the rate of absorption of glucose, fructose and mannose was markedly diminished. Simultaneously definite histological changes were observed in the intestinal mucosa. In spite of the decrease in the absolute amount absorbed, the relative rate of absorption of the three sugars mentioned remained nearly unchanged, indicating that the epithelial cells retained their selective action on sugars.
Cancer risk in primary biliary cirrhosis: a study in northern England
Authors: D Howel, J V Metcalf, J Gray, W L Newman, D E J Jones, O F W James
Journal: Gut (1999)

<h3>BACKGROUND</h3> Suggestions that breast cancer may be more common in patients with primary biliary cirrhosis (PBC) have been challenged. It has recently been proposed that total cancer rates may be higher in patients with PBC, as well as liver cancers. <h3>AIMS</h3> To investigate these proposals on a strictly defined case series. <h3>SUBJECTS</h3> A total of 769 prevalent or incident PBC patients with “definite” or “probable” disease detected in a defined area of the north-east of England during 1987–94. <h3>METHODS</h3> Cancer events and deaths were identified by obtaining information from one or more of the following sources: Office for National Statistics (ONS) Central Registers, Regional Cancer Registry, and clinical case records. Standardised cancer incidence (SIR) and mortality ratios (SMR) were calculated using the local region as the standard population. <h3>RESULTS</h3> There were 97 cancer events during 1987–96. SIR from cancer registrations for all cancers was 1.7 (95% confidence interval (CI) 1.3 to 2.2), for liver cancer was 74 (95% CI 32 to 146), and for breast cancer was 1.1 (95% CI 0.4 to 2.4). SMR for all cancers was 1.8 (95% CI 1.4 to 2.4), for liver cancer was 39 (95% CI 20 to 68), and for breast cancer was 0.4 (95% 0.1 to 1.6). The results were similar after excluding the first year of follow up after PBC diagnosis. <h3>CONCLUSIONS</h3> There was some evidence of a small increase in overall cancer incidence and mortality in PBC patients. With the exception of liver cancer, it is unlikely that there is a high excess incidence for PBC patients from any cancer at a particular site, and specifically breast cancer.
PREVALENCE AND OUTCOMES OF RECURRENT HOSPITAL ADMISSIONS IN PATIENTS WITH ATRIAL FIBRILLATION: INSIGHTS FROM THE GULF SURVEY OF ATRIAL FIBRILLATION EVENTS (GULF SAFE) REGISTRY
Authors: Nidal Asaad, Mohammad Zubaid, Mohammed Mohsen, Jassim Al-suwaidi, Rajvir Singh, Jassim Zaheen, Alawi Alsheikh-Ali, Wael Almahmeed, Wafa Rashed, Haitham Amin, Ahmed Al Qudaimi, Christian Bollensdorff, Magdi Yacoub
Journal: Journal of the American College of Cardiology (2015)
Embryology for Surgeons: The Embryological Basis for the Treatment of Congenital Defects
Authors: John G. Raffensperger
Journal: JAMA (1972)

For many years I have been searching for an authoritative textbook on embryology. The quest is now over, because Dr. Gray, an anatomist, and Dr. Skandalakis, a surgeon, have produced a really fine volume on the subject. It is remarkable how embryologists, by studying the static anatomy of thousands of embryos and fetuses, can describe for us the dynamic rapid changes which take place in human organogenesis. In<i>Embryology for Surgeons</i>the authors provide us with a background of normal embryology for the gastrointestinal, genitourinary, and cardiovascular-pulmonary systems. They then systematically review the congenital defects that can arise in these areas. The authors not only skillfully relate individual defects to stages in normal embryology, but estimate their frequency and distribution within the population. Embryologists who worked extensively with human and animal fetuses in the early part of this century made many fine detailed studies. These historical observations together with current