tbuckley/cabot-search huggingface dataset:
Methyl parathion in residential properties: relocation and decontamination methodology.
Authors: J Milton Clark, John Bing-Canar, Steve Renninger, Ralph Dollhopf, Jason El-Zein, Dave Star, Dea Zimmerman, Abul Anisuzzaman, Kathline Boylan, Terrence Tomaszewski, Ken Pearce, Rebecca Yacovac, Bobby Erlwein, John Ward
Journal: Environmental Health Perspectives (2002)

In November 1994 methyl parathion (MP), a restricted agricultural pesticide, was discovered to have been illegally sprayed within hundreds of residences in Lorain County, Ohio. Surface levels and air concentrations of MP revealed detectable levels of the pesticide 3 years after spraying. Because of the high toxicity of MP (lethal dose to 50% of rats tested [LD50] = 15 mg/kg) and long half-life indoors, risk-based relocation and decontamination criteria were created. Relocation criteria were derived based on levels of p-nitrophenol in urine, a metabolic byproduct of MP exposure. In Ohio, concentrations of MP on surfaces and in the air were also used to trigger relocations. The criteria applied in Ohio underwent refinement as cases of MP misuse were found in Mississippi and then in several other states. The MP investigation (1994-1997) was the largest pesticide misuse case in the nation, ultimately involving the sampling of 9,000 residences and the decontamination of 1,000 properties. This article describes the methodology used for relocation of residents and decontamination of properties having MP.
Preventing PID: Try Monogamy
Authors: Patricia Lee June
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Washington et al<sup>1</sup>have some good suggestions on preventing pelvic inflammatory disease (PID), yet under the category of "general preventive measures" they include several ways to somewhat decrease PID under "maintain healthy sexual behavior," but omit the single healthy sexual behavior that will virtually eliminate PID: limit sexual intercourse to a mutually monogamous relationship. This is the only sexual behavior guaranteed to prevent PID and other sexually transmitted diseases. It should be the goal that we advocate to our patients, with the measures listed by Washington et al being recommended as the next most useful methods that decrease but do not eliminate risk, for those who do not meet the primary goal.
Continuing Medical Education: Actually Learning Rather Than Simply Listening
Authors: Martyn O. Hotvedt
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The Ad Hoc Committee on Review and Evaluation for the Accreditation Council for Continuing Medical Education (ACCME) is charged with conducting an in-depth examination of the ACCME accreditation system, making recommendations concerning how ACCME can be structured to function efficiently and effectively, and ensuring physicians and the public that accredited CME activities meet acceptable educational standards. Even though the committee (of which I am a member) is making progress, it is clear that an improved accreditation system will continue to focus on educational activities defined by the Physician's Recognition Award (PRA) Category 1, and sponsored only by accredited educational programs. Although 1 requirement of ACCME is considering the needs of attending physicians, activities are still developed by the educational programs. For such programs to stay fiscally solvent, activities must be designed for large numbers of physicians at a time. Nearly all CME activities qualifying for Category 1
Estimated Benefits of Glycemic Control in Microvascular Complications in Type 2 Diabetes
Authors: Sandeep Vijan
Journal: Annals of Internal Medicine (1997)

Background: The benefits of intensive glycemic control in patients with type 2 diabetes are not well quantified. It is therefore not clear which patients will benefit most from aggressive glycemic control. Objective: To evaluate the efficacy of glycemic control in type 2 diabetes. Design: Markov decision model. Patients: Diabetic patients at a health maintenance organization. Main Outcome Measures: Risks for developing blindness and end-stage renal disease; number of patients and patient-years needed to treat to prevent complications. Results: For a patient in whom diabetes developed before 50 years of age, reducing hemoglobin A1c levels from 9% to 7% results in an estimated 2.3-percentage point decrease (from 2.6% to 0.3%) in lifetime risk for blindness due to retinopathy. The same change in a patient with diabetes onset at 65 years of age would be expected to decrease the risk for blindness by 0.5 percentage points (from 0.5% to <0.1%). However, the Markov model predicts substantially greater benefit when moving from poor to moderate glycemic control than when moving from moderate to almost-normal glycemic control. Targeting less than 20% of the patients at one health maintenance organization for intensified therapy may prevent more than 80% of the preventable patient-time spent blind. The risks for end-stage renal disease and the risk reduction provided by improved glycemic control are lower than those for blindness. Conclusions: This probability model, based on extrapolation from the experience with type 1 diabetes, suggests that patients with early onset of type 2 diabetes will accrue substantial benefit from almost-normal glycemic control. In patients with later onset, moderate glycemic control prevents most end-stage complications caused by microvascular disease. These results have important implications for informing patients and allocating health care resources.
Determinants of increased exhaled nitric oxide in patients with suspected asthma
Authors: L. P. Malmberg, H. Turpeinen, P. Rytilä, S. Sarna, T. Haahtela
Journal: Allergy (2005)

Exhaled nitric oxide (FENO) has been proposed as a marker of asthmatic inflammation, but it is unclear whether FENO in clinical use selects patients primarily according to their atopic or asthmatic status. The aim of this study was to investigate the determinants of increased FENO in patients with suspected asthma, by means of multinomial logistic regression analysis. The FENO of 132 patients referred because of symptoms suggestive of asthma were studied, and the explanatory factors tested included atopy according to prick skin tests, clinical asthma according to lung function tests, sputum eosinophilia and bronchial hyperresponsiveness (BHR). Slightly elevated FE(NO) levels were significantly explained only by sputum eosinophilia (OR: 3.7; 95% CI: 1.1-13.1; P=0.04), but for high levels of FE(NO) (> or =3 SD of predicted), clinical asthma (OR: 16.3; 95% CI: 5.4-49.7; P <0.0001) and sputum eosinophilia (OR: 12.0; 95% CI: 4.1-35.0; P >0.0001) were the characteristics with the highest prediction, followed by atopy and BHR. A significant interaction between asthma and atopy was observed relating to the effect on high FENO, but further analyses stratified by atopy showed significant associations between asthma and high FENO both in atopic and nonatopic patients. We conclude that in patients with symptoms suggesting asthma, slightly elevated and high levels of FENO are associated with sputum eosinophilia, whereas asthma is significantly associated only with high levels of FENO, irrespective of atopy. The results suggest that FENO is primarily a marker of airway eosinophilia, and that only high values of FENO may be useful to identify patients with atopic or nonatopic asthma.
Soft Tissue Roentgenography
Authors: Robert Lloyd Segal
Journal: JAMA (1960)

Among six patients who were proved at operation to have carcinoma of the thyroid three were found in whom the preoperative roentgenographic findings would have sufficed to give the diagnosis. In each of these three cases psammoma bodies were found in sections of the carcinoma. One out of four patients with local recurrences of thyroid carcinoma also showed characteristic malignant calcifications. In a total of 45 patients studied by soft-tissue radiography there were no false-positive diagnoses. In the differential diagnosis by roentgenography it is borne in mind that malignant calcifications are not dense but are poorly marginated, approximately uniform in size, grouped in streaks or in nebular formation, and without a calcific rim.
Genetic Analyses and Outcomes of Hematopoietic Stem Cell Transplantation in 12 Patients With T-B+NK+ SCID
Authors: G YU, D BERK, G DESAINTBASILE, N LAMBERT, P KNAPNOUGEL, E STIEHM, D UMETSU, D LEWIS, K NADEAU, M COWAN
Journal: Journal of Allergy and Clinical Immunology (2008)
Judge makes 15 year old girl ward of court after mother refuses to allow nasojejunal tube feeding
Authors: C. Dyer
Journal: BMJ (2014)

NHS trusts involved in disputes with families over their child’s treatment should not spend too long trying to secure parents’ agreement before taking the case to court, a UK High Court judge has warned.

Although trusts sometimes resorted to litigation too soon, in other cases crucial time could be lost trying to secure acquiescence, said Mr Justice Hayden, sitting in the Court of Protection in London.

The judge made declarations that it would be in the best interests of a 15 year old girl who …
Medical Innovation and the Critical Role of Health Technology Assessment
Authors: Seymour Perry
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPINK5 polymorphism and disease severity among Japanese children with atopic dermatitis
Authors: T. Kusunoki, I. Okafuji, T. Yoshioka, M. Saito, R. Nishikomori, T. Heike, M. Sugai, A. Shimizu, T. Nakahata
Journal: Journal of Allergy and Clinical Immunology (2005)
Isolation and characterization of a lower molecular weight protein doublet of horny cell outer leaflet: a possible novel epidermal differentiation marker
Authors: J.K. PARK, T. YOSHIIKE, H. YAGUCHI, H. OGAWA
Journal: British Journal of Dermatology (1992)

The water-soluble fraction of stratum corneum contains numerous unidentifiable proteins and polypeptides when examined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). Intensely stained polypeptide bands of low molecular weights (LMW) [8 and 10 kDa] are also present, and the abundance and invariable presence of this LMW protein doublet in the soluble proteins of stratum corneum prompted us to isolate and characterize them. Extracts of stratum corneum, using 8 M urea, 0.05 M Tris, pH 9.0, 0.025 M 2-mercaptoethanol, were dialysed against water. Water-insoluble proteins were removed by repeated dialysis and centrifugation. From the remaining soluble proteins, a LMW protein doublet was isolated by Sephadex G50 column chromatography and reversed-phase high-performance liquid chromatography (HPLC). The amino acid compositions of the 8 and 10 kDa proteins were similar to, but different from, those of known structural proteins in the stratum corneum. Rabbit antibody was raised against the 10-kDa protein band and cross-reacted with the 8-kDa protein band by Western immunoblot technique. The antibody recognized only this protein doublet amongst the proteins extracted from cultured keratinocytes. The 8- and 10-kDa proteins therefore appear to be closely related to, but different from, known structural proteins or degradation products. Immunofluorescence and immunoelectron microscopy demonstrated that this protein doublet was located in the cytoplasm of the cells of the malpighian layer, and in the outer layer of the marginal band of the horny layer. Its distribution was shown to be limited to stratified squamous epithelia by organ specificity studies. These results suggest that this protein doublet appears to be a novel soluble protein and a new epidermal differentiation marker of stratified epithelium.
The Arabidopsis lyrata genome sequence and the basis of rapid genome size change
Authors: Tina T Hu, Pedro Pattyn, Erica G Bakker, Jun Cao, Jan-Fang Cheng, Richard M Clark, Noah Fahlgren, Jeffrey A Fawcett, Jane Grimwood, Heidrun Gundlach, Georg Haberer, Jesse D Hollister, Stephan Ossowski, Robert P Ottilar, Asaf A Salamov, Korbinian Schneeberger, Manuel Spannagl, Xi Wang, Liang Yang, Mikhail E Nasrallah, Joy Bergelson, James C Carrington, Brandon S Gaut, Jeremy Schmutz, Klaus F X Mayer, Yves Van de Peer, Igor V Grigoriev, Magnus Nordborg, Detlef Weigel, Ya-Long Guo
Journal: Nature Genetics (2011)
Intrinsic and Acquired Resistance to Methotrexate in Acute Leukemia
Authors: Richard Gorlick, Erdem Goker, Tanya Trippett, Mark Waltham, Debabrata Banerjee, Joseph R. Bertino
Journal: New England Journal of Medicine (1996)

Methotrexate, a folic acid antagonist, is used extensively not only for the treatment of cancer but also for the treatment of rheumatoid arthritis, psoriasis, and autoimmune disease and for the prevention of graft-versus-host disease after transplantation. The drug is also used as an abortifacient.1,2 Other folate antagonists are used to treat bacterial infections (trimethoprim), malaria (pyrimethamine), and Pneumocystis carinii infection (trimetrexate with leucovorin).3,4 As with other drugs used to treat infectious diseases or cancers, the development of resistance limits the effectiveness of these folate antagonists. An understanding of the mechanisms of resistance to this class of drugs is . . .
THE SUBMUCOUS RESECTION OF THE NASAL SEPTUM.
Authors: LEE MAIDMENT HURD
Journal: JAMA (1907)

In the series of submucous resection cases which forms the basis of this paper, I find that the number of males predominates over the females three to one. The average age is 27.2 years. The youngest patient was 10 years of age; five patients were under 15 years of age; the oldest patient was 64 years. The deflection occurred one-third oftener to the left than to the right. Only six gave a clear traumatic history, while in one-third of the total there was an indefinite traumatic history. In all these cases the bone as well as the cartilage was involved. Seven patients had previously been operated on with the saw or by the Asch method. There were three perforations of the septum, equaling 4 per cent., one due to early inexperience, one to Ballenger's knife and one to a knife slipping off the anterior nasal spine while dividing a very
UPA-sensitive ACPP-conjugated nanoparticles for multi-targeting therapy of brain glioma
Authors: Bo Zhang, Yujie Zhang, Ziwei Liao, Ting Jiang, Jingjing Zhao, Yanyan Tuo, Xiaojian She, Shun Shen, Jun Chen, Qizhi Zhang, Xinguo Jiang, Yu Hu, Zhiqing Pang
Journal: Biomaterials (2014)
Computer aided prescribing leaves holes in the safety net
Authors: R E Ferner
Journal: BMJ (2004)

that there were no technical set-up problems that could have accounted for the observed failures, we reported the problems that were identified to the manufacturers and invited comment.None of the systems produced alerts for all of the 18 scenarios (table ).In terms of prescription of drugs with similar names, none of the systems warned for all 10 drug pairs considered.The evaluators produced no discrepancies in assessing the safety of systems.Each of the four system suppliers agreed with our assessments.We thank the PRIMIS staff for help with the system set up for the evaluation, GP computer system suppliers for responding constructively to our work, and Judy Cantrill and Caroline Morris for their involvement in the Delphi exercise.This work formed a part of BF's MSc thesis which was co-supervised by
Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis
Authors: Ying-Hsien Kao, Chao-Long Chen, Bruno Jawan, Yueh-Hua Chung, Cheuk-Kwan Sun, Shiao-Mei Kuo, Tsung-Hui Hu, Yu-Chun Lin, Hoi-Hung Chan, Kuang-Hung Cheng, Den-Chyang Wu, Shigeru Goto, Yu-Fan Cheng, David Chao, Ming-Hong Tai
Journal: Journal of Hepatology (2009)
Global Left Ventricle Myocardial Deformation Observed by Four-Dimensional Echocardiographic Evaluation was Impaired in Patients with Vitamin B12 Deficiency and Normal Conventional Echocardiographic Findings
Authors: Asuman Biçer Yeşilay, Funda Yalçın, Arzu Er, Aysun Camuzcuoğlu, Zekeriya Kaya, Nurhan Korkmaz, Yusuf Sezen, Özgür Günebakmaz, Mehmet Gencer, Recep Demirbağ
Journal: Journal of the American College of Cardiology (2013)
Quantification of asthma control: validation of the Asthma Control Scoring System
Authors: A. LeBlanc, P. Robichaud, Y. Lacasse, L.‐P. Boulet
Journal: Allergy (2006)

We developed an instrument for quantifying asthma control, the Asthma Control Scoring System (ACSS), based on the criteria proposed by the Canadian Asthma Consensus Guidelines.To assess the measurement properties of the ACSS.The ACSS and two other questionnaires were completed by 44 asthmatic patients on a first visit and 2 weeks later. The ACSS evaluates three types of parameters: clinical, physiologic, and inflammatory. These parameters are each quantified to obtain a maximal score of 100% and a global score is calculated as the mean of these scores.The analysis showed sufficient internal consistency for every section of the ACSS (Cronbach's-alpha ranging from 0.72 to 0.88). Pearson's correlations indicated good test-retest reliability for the clinical score (r = 0.59, P = 0.005), the physiologic score (r = 0.86, P < 0.0001), the inflammatory score (r = 0.71, P = 0.049), and the global score (r = 0.65, P = 0.001). Cross-sectional and longitudinal construct validity were supported by moderate correlations between the ACSS scores and corresponding instruments.The ACSS is a valid tool for quantifying asthma control parameters, using a percent score. Further research should determine the usefulness of such an instrument as a means to improve asthma management and reduce related morbidity.
The Pharmaceutic Exhibit at the Saratoga Meeting.
Authors: Wm. J. Robinson
Journal: JAMA (1902)

New York City, Aug. 9, 1902. <h3>To the Editor:</h3> —I read Mr. Gardner's letter in to-day's issue ofThe Journalwith peculiar interest. All his points are well taken and the grievances of both the exhibitors and of the medical profession with reference to this particular feature of the Association meetings are correctly and truthfully stated. But I think that complaints have now become superfluous, because the Association has—at the writer's initiative—at the last meeting adopted a resolution which will effectually prevent the continuance of the hitherto complained of abuses and will result in great benefit to both physician and exhibitor. The mismanagement at the last exhibit certainly seemed to have reached its climax. There was no restraint whatsoever to the admission of the public, and as several other societies happened to meet in Saratoga at the same time our Association did, the result was that the lay public practically
Pleural Fluid Complement
Authors: DAVID R. MUSHER
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 September 1972Pleural Fluid ComplementDAVID R. MUSHER, M.D.DAVID R. MUSHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-3-482_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest the article, "Pleural Fluid Complement in Systemic Lupus Erythematosus and Rheumatoid Arthritis," by HUNDER, MCDUFFIE, and HEPPER (Ann Intern Med 76:357-363, 1972). The article is important because it is one of several that help us to distinguish the causes of effusions in collagen diseases. We have seen patients with lupus peritonitis who had positive LE preparations and four-plus peripheral pattern antinuclear antibodies in paracentesis fluids. These findings were not unexpected; the patients were afflicted with an active systemic disease.To elucidate the causes of lowered complement levels and the interrelation between serum and...References1. RUDDYMÜLLER-EBERHARDAUSTEN SHK: Direct measurement of intra-articular hypercatabolism of third complement component (C3) in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) (abstract), Arthritis Rheum 14:410, 1971 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 3453-A South Stafford St. Arlington, Va. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHandling Sera and Obtaining Fluid from Different Compartments: Practical Considerations 1 September 1972Volume 77, Issue 3Page: 482-483KeywordsAntinuclear antibodiesCollagen diseasesLupus erythematosusPeritonitisRheumatoid arthritisSystemic diseases ePublished: 1 December 2008 Issue Published: 1 September 1972 PDF downloadLoading ...
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL– and mutant FLT3-expressing cells
Authors: Ellen Weisberg, Lolita Banerji, Renee D. Wright, Rosemary Barrett, Arghya Ray, Daisy Moreno, Laurence Catley, Jingrui Jiang, Elizabeth Hall-Meyers, Maira Sauveur-Michel, Richard Stone, Ilene Galinsky, Edward Fox, Andrew L. Kung, James D. Griffin
Journal: Blood (2008)
QUANTITATIVE ASSESSMENT OF MYOCARDIAL ISCHEMIA BY TL-201 SCINTIGRAPHY
Authors: Barry Massie, Judith Wisneski, Milton Hollenberg, Edward Gertz, Matteo Go, Debra Loge
Journal: Clinical Nuclear Medicine (1982)

Massie, Barry; Wisneski, Judith; Hollenberg, Milton; Gertz, Edward; Go, Matteo; Loge, Debra Author Information
Medicolegal Aspects of Cardiopulmonary Resuscitation (CPR) and Emergency Cardiac Care (ECC)
Authors: Kevin M. McIntyre
Journal: JAMA (1980)

The National Conference on CPR and ECC that was held in Dallas in September 1979 developed standards and guidelines for the performance of ECC. Included was a panel on medicolegal aspects that defined areas of legal vulnerability and made certain recommendations. Two aspects of the medicolegal panel's deliberations deserve special attention by anyone involved in CPR and ECC. These two aspects involve (1) decision making, primarily the decisions to initiate, withhold, and terminate CPR, and (2) the quality of performance if the decision to initiate is made. <h3>Decision Making in CPR</h3> Decision making at the point of either initiation or termination of CPR is equivalent to defining whether the cardiac arrest victim should be pronounced dead or could and should be resuscitated. Guidelines for such decisions should be clear, consistent, and easy to implement. They should not be arbitrary. The touchstone of the legal propriety of such decisions is good