Review of Comparative Effectiveness of Treatments to Prevent Fractures
Authors: Catherine MacLean, Margaret Maglione, Marika Suttorp
Journal: Annals of Internal Medicine (2008)

Letters3 June 2008Review of Comparative Effectiveness of Treatments to Prevent FracturesCatherine MacLean, MD, PhD, Margaret Maglione, MPP, and Marika Suttorp, MSCatherine MacLean, MD, PhDFrom RAND Corporation, Santa Monica, CA 90401.Search for more papers by this author, Margaret Maglione, MPPFrom RAND Corporation, Santa Monica, CA 90401.Search for more papers by this author, and Marika Suttorp, MSFrom RAND Corporation, Santa Monica, CA 90401.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-11-200806030-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Rosen is correct. The study he references (1) was included in our analysis but was not called out in the section on renal insufficiency. This trial reported the effect of risedronate on fractures among participants with varying degrees of renal insufficiency. This study, which combined data from 9 randomized, double-blind, placebo-controlled trials, reported a reduced incidence of vertebral fractures with risedronate compared with placebo in participants with severe, moderate, and mild renal insufficiency.Although not reported in our paper, we did collect data and calculate pooled estimates for all adverse events reported in all studies reviewed. Details ...References1. Miller PD, Roux C, Boonen S, Barton IP, Dunlap LE, Burgio DE. Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials. J Bone Miner Res. 2005;20:2105-15. [PMID: 16294264] CrossrefMedlineGoogle Scholar2. MacLean C, Alexander A, Carter J, Chen S, Desai SB, Grossman J, et al. Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low Bone Density or Osteoporosis. Comparative Effectiveness Review No. 12. (Prepared by the Southern California/RAND Evidence-based Practice Center under contract 290-02-0003). Rockville, MD: Agency for Healthcare Research and Quality; December 2007. Accessed at www.effectivehealthcare.ahrq.gov/reports/final.cfm on 24 April 2008. Google Scholar3. Grady D, Ettinger B, Moscarelli E, Plouffe L, Sarkar S, Ciaccia A, et al; Multiple Outcomes of Raloxifene Evaluation Investigators. Safety and adverse effects associated with raloxifene: multiple outcomes of raloxifene evaluation. Obstet Gynecol. 2004;104:837-44. [PMID: 15458908] CrossrefMedlineGoogle Scholar4. Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. National Surgical Adjuvant Breast and Bowel Project (NSABP). Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA. 2006;295:2727-41. [PMID: 16754727] CrossrefMedlineGoogle Scholar5. Stevenson M, Jones ML, De Nigris E, Brewer N, Davis S, Oakley J. A systematic review and economic evaluation of alendronate, etidronate, risedronate, raloxifene and teriparatide for the prevention and treatment of postmenopausal osteoporosis. Health Technol Assess. 2005;9:1-160. [PMID: 15929857] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Catherine MacLean, MD, PhD; Margaret Maglione, MPP; Marika Suttorp, MSAffiliations: From RAND Corporation, Santa Monica, CA 90401.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystematic Review: Comparative Effectiveness of Treatments to Prevent Fractures in Men and Women with Low Bone Density or Osteoporosis Catherine MacLean , Sydne Newberry , Margaret Maglione , Maureen McMahon , Veena Ranganath , Marika Suttorp , Walter Mojica , Martha Timmer , Alicia Alexander , Melissa McNamara , Sheetal B. Desai , Annie Zhou , Susan Chen , Jason Carter , Carlo Tringale , Di Valentine , Breanne Johnsen , and Jennifer Grossman Review of Comparative Effectiveness of Treatments to Prevent Fractures Harold Rosen Review of Comparative Effectiveness of Treatments to Prevent Fractures Lionel S. Lim Review of Comparative Effectiveness of Treatments to Prevent Fractures John L. Stock , John L. Mershon , and Michael Jay Schoenfeld Review of Comparative Effectiveness of Treatments to Prevent Fractures Dennis M. Black , Steven Boonen , Pierre Delmas , and Kenneth W. Lyles Review of Comparative Effectiveness of Treatments to Prevent Fractures Robert Karis Metrics 3 June 2008Volume 148, Issue 11Page: 887KeywordsAdverse eventsConflicts of interestHip fracturesMyalgiaPopulation statisticsRenal analysisResearch designRisk managementSystematic reviews ePublished: 3 June 2008 Issue Published: 3 June 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...