tbuckley/cabot-search huggingface dataset:
Can limited pulmonary resection replace lobectomy for small sized lung cancer?
Authors: T J Warke
Journal: Thorax (2003)

▴ Koike T, Yamato Y, Yoshiya K, et al . Intentional limited pulmonary resection for peripheral T1N0M0 small-sized lung cancer. J Thorac Cardiovasc Surg2003;125:924–8 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] In this study, patients with stage 1a peripheral non-small cell lung cancer (⩽2 cm maximum diameter) underwent either standard lobectomy (n=159) or limited resection (segmentectomy or wedge resection, n=74). All patients were considered fit for lobectomy and limited … [1]: {openurl}?query=rft.jtitle%253DThe%2BJournal%2Bof%2BThoracic%2Band%2BCardiovascular%2BSurgery%26rft.stitle%253DJ.%2BThorac.%2BCardiovasc.%2BSurg.%26rft.issn%253D0022-5223%26rft.aulast%253DKoike%26rft.auinit1%253DT.%26rft.volume%253D125%26rft.issue%253D4%26rft.spage%253D924%26rft.epage%253D928%26rft.atitle%253DIntentional%2Blimited%2Bpulmonary%2Bresection%2Bfor%2Bperipheral%2BT1%2BN0%2BM0%2Bsmall-sized%2Blung%2Bcancer%26rft_id%253Dinfo%253Adoi%252F10.1067%252Fmtc.2003.156%26rft_id%253Dinfo%253Apmid%252F12698157%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1067/mtc.2003.156&link_type=DOI [3]: /lookup/external-ref?access_num=12698157&link_type=MED&atom=%2Fthoraxjnl%2F58%2F9%2F751.atom [4]: /lookup/external-ref?access_num=000182327700022&link_type=ISI
Fibrinolytic actions of intra-arterial angiotensin II and bradykinin in vivo in man
Authors: C Labinjoh
Journal: Cardiovascular Research (2000)

Angiotensin II and bradykinin are potent endogenous vasoactive peptides which may play a role in the regulation of endogenous fibrinolysis and, thereby, contribute to the beneficial actions of ACE inhibitors. The aims of the study were to determine the acute effect of angiotensin II and bradykinin on the local vascular release of tissue plasminogen activator (t-PA) and its inhibitor, plasminogen activator inhibitor type 1 (PAI-1), and the endothelium-derived haemostatic factor, von Willebrand factor (vWf) from the forearm.Blood flow, and plasma haemostatic and fibrinolytic factors, were measured in both forearms of sixteen healthy men: eight subjects received intra-arterial angiotensin II (5, 50 and 500 pmol/min) which was coinfused with sodium nitroprusside (SNP; 0.3, 1.5 and 7.5 microg/min, respectively), and eight received intra-arterial bradykinin at 10-3000 pmol/min.Despite substantial rises in plasma angiotensin II concentrations (P<0.001) which caused pressor effects (P<0.003) at the highest dose, angiotensin II infusion did not affect local plasma t-PA, PAI-1 or vWf concentrations. In contrast, bradykinin caused substantial dose-dependent increases in blood flow and t-PA release (>100 ng/100 ml of tissue/min) in the infused forearm (P<0. 001 for both) without affecting plasma PAI-1 or vWf concentrations.Despite high local concentrations with breakthrough of significant systemic effects, angiotensin II did not affect acute endothelial cell t-PA, PAI-1 or vWf release in healthy men. In contrast, bradykinin is a potent vasodilator and selective stimulus for acute local t-PA release. This may, at least in part, explain the fibrinolytic actions of ACE inhibitors in heart failure and ischaemic heart disease.
Medicine and the Management of Living: Taming the Last Great Beast
Authors: Norman M. Jensen
Journal: JAMA (1985)

No observer can avoid some interest in the rapidly changing world of physician-patient encounters. Arney and Bergen provide us with a fresh and provocative analysis of this change. The authors seem content with the traditional sociological view that it is useful to examine the distribution of power in the physician-patient relationship, but they are critical of the lack of attention to language as a means by which the reality of the patient's experience is created and displayed in the encounter. Borrowing heavily from the French sociologist Michael Foucault, the authors find it useful to frame "power" in a new sense of work mutually accomplished by persons in social situations rather than in the traditional sense of unilateral "exclusionary practices." The authors argue that contemporary thought would have us believe that patients are in the process of achieving a liberation through political work and the assertive acquisition of medical knowledge in
Predisposition to Atopic Symptoms to Inhaled Antigens May Protect From Childhood Type 1 Diabetes
Authors: Petri S. Mattila, Jussi Tarkkanen, Harri Saxen, Janne Pitkäniemi, Marjatta Karvonen, Jaakko Tuomilehto
Journal: Diabetes Care (2002)

OBJECTIVE—To assess the inverse association between type 1 diabetes and asthma to establish whether environmental and/or genetic factors predisposing to asthma or to atopic symptoms to inhaled antigens protect from diabetes. RESEACH DESIGN AND METHODS—Questionnaires were returned by 306 probands with childhood type 1 diabetes, their 506 nonaffected siblings, and 406 age- and sex-matched unaffected population control subjects. The main outcome measures were self-reported physician-diagnosed asthma and atopic symptoms to animal dust and pollen. RESULTS—Risk of diabetes was inversely associated with asthma (odds ratio 0.49 [95% CI 0.24–1.00]), allergy to animal dust (0.67 [0.45–0.99]), and to a lesser degree to pollen (0.74 [0.51–1.07]) when the probands were compared with the population control subjects. Among the children of the families of an affected proband, the risk of diabetes appeared to be inversely associated with asthma (0.54 [0.27–1.09]) but not with allergy to animal dust (0.99 [0.66–1.47]) nor allergy to pollen (0.88 [0.62–1.27]). CONCLUSIONS—The frequency of asthma and atopic symptoms to some inhaled antigens is decreased in individuals with childhood type 1 diabetes. Factors predisposing to atopic symptoms to inhaled antigens may protect from childhood type 1 diabetes.
Once more with feeling: The role of emotion in self-deception
Authors: Tim Dalgleish
Journal: Behavioral and Brain Sciences (1997)

In an analysis of the role of emotion in self-deception is presented. It is argued that instances of emotional self-deception unproblematically meet Mele's jointly sufficient criteria. It is further proposed that a consideration of different forms of mental representation allows the possibility of instances of self-deception in which contradictory beliefs (in the form p and ~ p ) are held simultaneously with full awareness.
Continuous Aneroid Arterial Pressure Monitor
Authors: Austin L. Gardner
Journal: JAMA (1969)

To the Editor:—  A recent communication describes a simplified method of monitoring arterial pressure with an aneroid manometer attached to a syringe with a finger cot inside. This technique was a modification of a commercial instrument that in turn was an attempt to partially obviate the strain-gauge. 1   An even simpler method is possible and consists of an aneroid manometer attached to the rubber connection of an intravenous set which in turn is fitted into a vena tube that is attached to the side arm of a three-way stopcock. Flushing with heparin and saline solution must be carried out just before turning the circuit to the manometer. Protecting the manometer with a finger cot fitted in a syringe has not been found necessary.  This is not an original method and I do not know who first used it. I have found it quite helpful in monitoring patients during aortography (Figure).
The Intermediate Coronary Care Unit.
Authors: William J. Grace
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971The Intermediate Coronary Care Unit.William J. Grace, M.D., Patricia M. Yarvote, M.D.William J. Grace, M.D.Search for more papers by this author, Patricia M. Yarvote, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-819_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAfter discharge from a coronary care unit a number of patients die. As much as 30% of all hospital deaths from acute myocardial infarction occur after the sixth day or after discharge from the coronary care unit. In our experience at least half of these deaths are sudden and unexpected. To study the problem, a special area in the general hospital was equipped for continuous ECG monitoring using telemetry. The area was also equipped with the usual life support measures in the event of cardiac arrest, and the assigned nurses were given special courses in ECG and resuscitation. To date... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 819-819KeywordsAcute myocardial infarctionCardiac care unitHeartResuscitation Issue Published: 1 May 1971 PDF DownloadLoading ...
Waiting time targets are achievable, says Department of Health
Authors: Sally Hargreaves
Journal: BMJ (2007)

Round the clock surgery could be introduced in England as part of a renewed bid to ensure that, by the end of 2008, patients wait no longer than 18 weeks from being referred by their GP for an operation to treatment, the prime minister said this week.

Ambitious targets for waiting lists were outlined in 2004 by the government in the NHS Improvement Plan. Figures released this week show that waiting lists in England are at their shortest ever, and patients are waiting a maximum of six months for operations.

In addition, the overall number of patients waiting for treatment dropped by 8000 to 769 000 between October and November 2006, the lowest since the records began in 1987. The Department of Health says that the NHS has also met its target for a maximum wait by outpatients of 13 weeks …
Race/Ethnicity, Quality of Care, and Outcomes in Ischemic Stroke
Authors: Lee H. Schwamm, Mathew J. Reeves, Wenqin Pan, Eric E. Smith, Michael R. Frankel, DaiWai Olson, Xin Zhao, Eric Peterson, Gregg C. Fonarow
Journal: Circulation (2010)

Background— Prior studies suggest differences in stroke care associated with race/ethnicity. We sought to determine whether such differences existed in a population of black, Hispanic, and white patients hospitalized with stroke among hospitals participating in a quality-improvement program. Methods and Results— We analyzed in-hospital mortality and 7 stroke performance measures among 397 257 patients admitted with ischemic stroke to 1181 hospitals participating in the Get With The Guidelines-Stroke program 2003 through 2008. Relative to white patients, black and Hispanic patients were younger and more often had diabetes mellitus and hypertension. After adjustment for both patient- and hospital-level variables, black patients had lower odds relative to white patients of receiving intravenous thrombolysis (odds ratio [OR], 0.84; 95% confidence interval [CI], 0.77 to 0.91), deep vein thrombosis prophylaxis (OR, 0.88; 95% CI, 0.83 to 0.92), smoking cessation (OR, 0.85; 95% CI, 0.79 to 0.91), discharge antithrombotics (OR, 0.88; 95% CI, 0.84 to 0.92), anticoagulants for atrial fibrillation (OR, 0.84; 95% CI, 0.75 to 0.94), and lipid therapy (OR, 0.91; 95% CI, 0.88 to 0.96), and of dying in-hospital (OR, 0.90; 95% CI, 0.85 to 0.95). Hispanic patients received similar care as their white counterparts on all 7 measures and had similar in-hospital mortality. Black (OR, 1.31; 95% CI, 1.28 to 1.35) and Hispanic (OR, 1.16; 95% CI, 1.11 to 1.20) patients had higher odds of exceeding the median length of hospital stay relative to whites. During the study, quality of care improved in all 3 race/ethnicity groups. Conclusions— Black patients with stroke received fewer evidence-based care processes than Hispanic or white patients. These differences could lead to increased risk of recurrent stroke. Quality of care improved substantially in the Get With The Guidelines-Stroke Program over time for all 3 racial/ethnic groups.
OBSERVATIONS ON A SUBMICROSCOPIC BASOPHILIC COMPONENT OF CYTOPLASM
Authors: Keith R. Porter
Journal: The Journal of Experimental Medicine (1953)

The cytoplasmic ground substance of animal tissue cells grown in vitro has been found by electron microscopy to contain, as a part of its submicroscopic structure, a complex reticulum of strands, to be referred to as the endoplasmic reticulum. It has been found in all types of cells extensively studied. The components of this reticular system vary considerably in size and form, apparently in some relation to physiological changes in the cell. Thus in one cell of a culture colony it may be finely divided into strands or canaliculi, 50 to 100 mmicro in diameter, whereas in an adjacent cell of the same type the components of the reticulum may be relatively coarse, 600 mmicro in diameter, and vesiculated. The membrane, which can be shown to limit the system and separate it from the rest of the ground substance, is similar in thickness to the plasma membrane surrounding the cell. Photomicrographs of living cells taken by phase contrast and dark field microscopy define a structure of similar form and indicate that the reticulum of the electron microscope image has its equivalent in the living unit. Where its component units are sufficiently large, a structure of identical form can be resolved by light microscopy in cells stained with hematoxylin or with toluidine blue. This indicated that the endoplasmic reticulum is to be identified with the basophilic or chromophilic component (the ergastoplasm) of the cytoplasm and that such properties of this component as have been determined by cytochemical methods, such as a high RNA content, may be assigned to this "submicroscopic" system.
EXPERIMENTAL HIGH JEJUNOSTOMY IN THE DOG, WITH BLOOD CHEMICAL STUDIES
Authors: Russell L. Haden, Thomas G. Orr
Journal: The Journal of Experimental Medicine (1926)

1. The effect of high jejunostomy upon the life and chemical changes of the blood of dogs is here reported. 2. Sodium chloride solution administered in sufficient quantity after high jejunostomy prolongs the life of dogs. 3. Such experimental findings as these warrant a careful cinical study of the effects of high jejunostomy so frequently used in the treatment of acute intestinal obstruction.
MYOPIA ASSOCIATED WITH OPACITIES OF THE CORNEA.
Authors: WALTER L. PYLE
Journal: JAMA (1907)

Although the association of myopia with opacities of the cornea, as well as with opacities of the crystalline and its envelopes, has been recognized for over a half century, little mention of this fact is found in modern ophthalmic literature. Among the authors of recent ophthalmic text-books in English, it is practically ignored. The prevalence of corneal opacities in the cases of myopia studied in the older Continental schools and clinics is most striking to a modern American ophthalmologist. The statistics of Cohn<sup>1</sup>show a percentage of nearly 100 in school children. Among Arlt's<sup>2</sup>patients the association was found in 70 per cent. Additional published statistics are as follows: Chauvel,<sup>3</sup>49.7 per cent.; Petersen,<sup>4</sup>48 per cent., and Frenkel,<sup>5</sup>38.5 per cent. Among other writers on this subject are Donders, Nicati,<sup>6</sup>Werth, Landolt,<sup>7</sup>Gelpke,<sup>8</sup>Roure,<sup>9</sup>Manguis,<sup>10</sup>Hess,<sup>11</sup>Fortin,<sup>12</sup>
Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils
Authors: Finn-Eirik Johansen, Espen S. Baekkevold, Hege S. Carlsen, Inger Nina Farstad, Dulce Soler, Per Brandtzaeg
Journal: Blood (2005)
What skills do doctors and nurses need?
Authors: F. Godlee
Journal: BMJ (2008)

What’s the difference between a doctor and a nurse? Our cover picture this week suggests that the differences are becoming harder to spot, and in this issue Rebecca Coombes explores the shifting and increasingly overlapping territories of the two professions (doi:10.1136/bmj.a1522). It’s easy to understand why the nurse’s role is expanding into traditionally medical areas of diagnosis and treatment: there’s the lower direct cost of employing nurses and the fact that they have more time to spend with patients. 

But it’s not all plain sailing. There’s confusion over titles, a lack of nationally agreed standards on what training …
Analysis of altered gene expression during sustained atrial fibrillation in the goat
Authors: V Thijssen
Journal: Cardiovascular Research (2002)

Objective: Atrial fibrillation (AF) is characterised by electrical, gap junctional and structural remodelling. However, the underlying molecular mechanisms of these phenomena are largely unknown. To get more insight into atrial remodelling at the molecular level we have analysed changes in gene expression during sustained AF in the goat. Methods: The differential display technique (DD) was used to identify genes differentially expressed during sustained AF (13.9±5.2 weeks) as compared to sinus rhythm (SR). Dot-blot analysis was performed to confirm the altered gene expression and to establish the changes in expression after 1, 2, 4, 8 and 16 weeks of AF. Immunohistochemistry and western blotting were used to validate the DD approach and to further characterise the changed expression of the β-myosin heavy chain gene at the protein level. Results: Of the approximately 125 fragments that showed changed expression levels during AF, 34 were cloned and sequenced. Twenty-one of these represented known genes involved in cardiomyocyte structure, metabolism, expression regulation, or differentiation status. The changed expression of 70% of the isolated clones could be confirmed by dot-blot analysis. In addition, time course analysis revealed different profiles of expression as well as transient re-expression of genes, e.g. the gene for hypoxia-inducible factor 1α during the first week of AF. During sustained AF the frequency of cardiomyocytes expressing β myosin heavy chain (βMHC) increased from 21.8±2.1 to 47.9±2.5% (S.E.M.). The overall expression of MHC (α+β) appeared to be down-regulated during AF. Conclusions: AF is accompanied by changes in expression of proteins involved in cellular structure, metabolism, gene expression regulation and (de-)differentiation. Most alterations in expression confirm or support the hypothesis of cardiomyocyte de-differentiation. Furthermore, the results suggest a role for ischemic stress in the early response of cardiomyocytes to AF, possibly via activation of hypoxia-inducible factor 1α.
BAROREFLEX ACTIVATION THERAPY PROVIDES DURABLE BENEFIT IN PATIENTS WITH RESISTANT HYPERTENSION: LONG-TERM FOLLOW-UP RESULTS FROM THE RHEOS PIVOTAL TRIAL
Authors: George L. Bakris, Mitra K. Nadim, Hermann Haller, Eric Lovett, Jill E. Schafer, John Bisognano
Journal: Journal of the American College of Cardiology (2012)
Haemodialysis-membrane biocompatibility and mortality of patients with dialysis-dependent acute renal failure: a prospective randomised multicentre trial
Authors: Achim Jörres, Gerhard M Gahl, Clemens Dobis, Momir H Polenakovic, Koco Cakalaroski, Boleslaw Rutkowski, Ewa Kisielnicka, Detlef H Krieter, K Wolfgang Rumpf, Christian Guenther, Wilhelm Gaus, Josef Hoegel
Journal: The Lancet (1999)
Balancing Science and Informed Choice in Decisions about Vertebroplasty
Authors: James N. Weinstein
Journal: New England Journal of Medicine (2009)

Worldwide there are approximately 1.4 million persons with vertebral compression fractures.1 In the United States, there are approximately 750,000; only one third receive treatment.2 Prevalence estimates are imprecise because of heterogeneity in how vertebral fracture is defined.3 Annualized direct care expenditures for osteoporotic fractures in the United States were estimated to range from $12 billion to $18 billion in 2002.2 Several treatments (e.g., bed rest, bracing, and pain medications) have been designed to foster pain relief and allow for increased activities. Percutaneous vertebroplasty — the injection of polymethylmethacrylate directly into the vertebral compression fracture — has emerged as a treatment . . .
Novel Snake Venom Ligand Dendroaspis Natriuretic Peptide Is Selective for Natriuretic Peptide Receptor-A in Human Heart
Authors: Gurminder Singh, Rhoda E. Kuc, Janet J. Maguire, Mark Fidock, Anthony P. Davenport
Journal: Circulation Research (2006)

The natriuretic peptides are considered to be cardioprotective; however, their receptors have not been identified in human myocardium using radiolabeled analogs. Dendroaspis natriuretic peptide (DNP) has been recently identified as a new member of this peptide family and is thought to be less susceptible to enzymatic degradation. Therefore, we have developed the novel radiolabeled analog [125I]-DNP and used this to localize high-affinity (K(D)=0.2 nmol/L), saturable, specific binding sites in adult human heart (n=6) and coronary artery (n=8). In competition binding experiments, atrial natriuretic peptide and brain type natriuretic peptide had greater affinity for [125I]-DNP binding sites than C-type natriuretic peptide and the natriuretic peptide receptor (NPR)-C ligand, cANF. This rank order of potency suggested binding of [125I]-DNP was specific to NPR-A. Messenger RNA encoding NPR-A was identified in left ventricle and coronary artery smooth muscle, and expression was confirmed by immunocytochemical studies at the protein level. In addition, fluorescence dual labeling immunocytochemistry localized NPR-A protein to cardiomyocytes, endocardial endothelial cells, and smooth muscle of intramyocardial vessels. Importantly, we demonstrated a significant downregulation in the density of NPR-A in heart and coronary artery of patients with ischemic heart disease that may explain, in part, the attenuated natriuretic peptide response reported in this patient group.
Hyperparathyroidism — Too Little, Too Much Surgery?
Authors: Oliver Cope
Journal: New England Journal of Medicine (1976)

In the article entitled "Parathyroid Autotransplantation in Primary Parathyroid Hyperplasia" appearing elsewhere in this issue of the Journal Wells and his colleagues have demonstrated that it is possible with care and finesse to graft hyperplastic parathyroid tissue into the front of the forearm of the patient from whom the gland was removed, with evidence later that the grafted pieces are able to secrete parathyroid hormone. This procedure is handy to know about in case the surgeon is driven into it by having taken out too much parathyroid tissue. But its success is far from indicating that it provides the way . . .
Selective Nontreatment of Handicapped Newborns: Moral Dilemmas in Neonatal Medicine
Authors: Jon F. Watchko
Journal: JAMA (1984)

Practitioners of modern perinatal medicine face many quandaries but perhaps none more disconcerting than decision making as it relates to critically ill and handicapped infants. In response to this dilemma, a flood of analysis and conclusions has been generated. This book is one of the first attempts in the literature to comprehensively examine the issues relating to selective nontreatment of critically ill and handicapped infants. As such, it should be considered an important contribution. Robert Weir, Professor of Religious Studies at Oklahoma State University, begins his analysis with a discussion of the historical aspects of infanticide and proceeds to examine this act in modern contexts. In subsequent chapters, he presents the numerous and varied perspectives of practitioners from the medical community, the legal profession, and the sphere of biomedical ethics regarding selective nontreatment issues. This ambitious overview is broad in scope and is the book's greatest strength. As an example
Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation
Authors: Donatella Vairo, Laura Tassone, Giovanna Tabellini, Nicola Tamassia, Sara Gasperini, Flavia Bazzoni, Alessandro Plebani, Fulvio Porta, Luigi D. Notarangelo, Silvia Parolini, Silvia Giliani, Raffaele Badolato
Journal: Blood (2011)