tbuckley/cabot-search huggingface dataset:
Inhibitor of the factor VIIa-tissue factor complex is reduced in patients with disseminated intravascular coagulation but not in patients with severe hepatocellular disease.
Authors: M S Bajaj, S V Rana, R B Wysolmerski, S P Bajaj
Journal: Journal of Clinical Investigation (1987)

Inhibition of Factor VIIa-tissue factor activity by a plasma component(s) that requires factor Xa has been described recently. In this communication, we have developed a specific radiometric assay (which utilizes 3H-Factor IX and is sensitive to less than 1% of plasma level) for this inhibitor and have measured its activity in various disease states. Strikingly, the levels of this inhibitor were found to be normal in patients with advanced chronic hepatocellular disease but low in patients with disseminated intravascular coagulation (DIC). When endotoxin was used to induce DIC in rabbits, the levels of this inhibitor fell by 25-90%. Human umbilical vein endothelial cells (HUVE), bovine pulmonary artery endothelial cells, and a human hepatoma cell line (HepG2) all synthesized and secreted this inhibitor, whereas a promyelocytic cell line (HL-60) did not and a monocytic cell line (U937) appears to synthesize only small amounts. When ammonium sulfate-fractionated human plasma and serum-free conditioned media from both HUVE and HepG2 cells were electrophoresed on sodium dodecyl sulfate acrylamide gels, two activity peaks corresponding to Mr approximately 45,000 and Mr approximately 33,000 were eluted in each case. These observations suggest that (a) the inhibitor is consumed in DIC and that (b) endothelial cells (or other cells) synthesize sufficient amounts of this inhibitor in vivo to compensate for any decreased production by liver cells.
National audits need more sensitive and specific outcome measures for quality improvement
Authors: R. Nelson, R. Kerr, P. May, N. Kitchen, A. Jenkins
Journal: BMJ (2014)

We agree with Westaby’s views on publishing individual surgeons’ death rates.1 In April, the Society of British Neurological Surgeons launched the Neurosurgical National Audit Programme (NNAP)—a comprehensive audit of elective and non-elective neurosurgical services. The NNAP has been mandated by NHS England to publish surgeon and unit level death rates in the 2014 Consultant Outcome Publication. Through the NNAP, neurosurgeons have undertaken a …
Functional and Structural Deficits in Brain Regions Subserving Face Perception in Schizophrenia
Authors: Toshiaki Onitsuka, Margaret A. Niznikiewicz, Kevin M. Spencer, Melissa Frumin, Noriomi Kuroki, Lisa C. Lucia, Martha E. Shenton, Robert W. McCarley
Journal: American Journal of Psychiatry (2006)

OBJECTIVE: Schizophrenia impairs many cognitive functions, including face perception. Veridical face perception is critical for social interaction, including distinguishing friend from foe and familiar from unfamiliar faces. The main aim of this study was to determine whether patients with schizophrenia show less activation in neural networks related to face processing, compared with healthy subjects, and to investigate the relationships between this functional abnormality and anatomical abnormalities in the fusiform gyrus shown with magnetic resonance imaging (MRI). METHOD: Twenty male chronic schizophrenia patients and 16 healthy comparison subjects matched with the patients for age, gender, handedness, and parental socioeconomic status underwent high-spatial-resolution MRI. Event-related potentials elicited by images of faces, cars, and hands were recorded in a separate session. RESULTS: Compared to the healthy subjects, the patients with schizophrenia showed bilateral N170 amplitude reduction in response to images of faces but not to images of other objects. The patients also had smaller bilateral anterior and posterior fusiform gyrus gray matter volumes, compared to the healthy subjects. In addition, right posterior fusiform gyrus volume was significantly correlated with N170 amplitude measured at the right posterior temporal electrode site in response to images of faces in the schizophrenia patients but not in the healthy comparison subjects. CONCLUSIONS: The results provide evidence for deficits in the early stages of face perception in schizophrenia. The association of these deficits with smaller fusiform gyrus volume in patients with schizophrenia, relative to healthy subjects, suggests that the fusiform gyrus is the site of a defective anatomical substrate for face processing in schizophrenia.
Delirium at the End of Life
Authors: Thomas E. Finucane
Journal: Annals of Internal Medicine (2002)

Letters20 August 2002Delirium at the End of LifeThomas E. Finucane, MDThomas E. Finucane, MDJohns Hopkins Bayview Medical Center; Baltimore, MD 21224Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-4-200208200-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:For the treatment of delirium near the end of life, Casarett and Inouye (1) emphasize haloperidol, “which one randomized, controlled trial has shown to be superior to benzodiazepines” in hospitalized patients with AIDS who become delirious. This trial (2) compared haloperidol, chlorpromazine, and lorazepam with no placebo arm. A total of 6 patients received lorazepam, all had adverse effects, and the authors stopped that arm of the trial. Eleven patients received haloperidol, and 13 received chlorpromazine; there was no important difference between these two neuroleptic agents.When biological plausibility is considered, it is not obvious that a ...References1. Casarett DJ, Inouye SK. Diagnosis and management of delirium near the end of life. Ann Intern Med. 2001;135:32-40. [PMID: 11434730] LinkGoogle Scholar2. Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, et al . A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry. 1996;153:231-7. [PMID: 8561204] CrossrefMedlineGoogle Scholar3. . Ziprasidone (Geodon) for schizophrenia. Med Lett Drugs Ther. 2001;43:51-2. [PMID: 11402259] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Thomas E. Finucane, MDAffiliations: Johns Hopkins Bayview Medical Center; Baltimore, MD 21224 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDiagnosis and Management of Delirium near the End of Life David J. Casarett and Sharon K. Inouye , for the American College of Physicians–American Society of Internal Medicine End-of-Life Care Consensus Panel*Delirium at the End of Life David Casarett and Sharon Inouye Metrics Cited byHospice for the Terminally Ill and End-of-Life CareSecondary Stroke Prevention Strategies for the Oldest PatientsTerminal Care: The Last Weeks of Life 20 August 2002Volume 137, Issue 4Page: 295KeywordsAIDSAdverse reactionsAntipsychoticsBrainChlorpromazineConsciousnessDeliriumDrugsHyponatremiaSepsis ePublished: 20 August 2002 Issue Published: 20 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 3393: Antibody-based array proteomics identify proteins differentially expressed in human metastatic and non-metastatic triple negative breast cancer cells
Authors: Maria P. Roberti, Juan M. Arriaga, Michele Bianchini, Héctor R. Quintá, Alicia I. Bravo, Estrella M. Levy, José Mordoh, María M. Barrio
Journal: Cancer Research (2012)

Abstract Triple negative breast cancers (TNBC) lacking hormone receptors (ER, PR) and HER-2 amplification are very aggressive tumors. The IIB-BR-G cell line isolated from a primary TNBC, and its spontaneous metastatic variant, IIB-BR-G-MTS6 were compared using an antibody-based protein array to characterize their expression profile. We also analyzed their growth kinetics, migration, invasiveness, lymphangiogenesis and cytoskeleton structure. Doubling times in vitro were shorter for IIB-BR-G although in vivo IIB-BR-G-MTS6 tumors grew significantly faster than IIB-BR-G. IIB-BR-GMTS6 showed higher anchorage independent growth in a clonogenic assay. IIB-BR-G-MTS6 cells showed 100% incidence of lymph node metastasis at 5-6 weeks, although no metastasis was observed for IIB-BR-G even 19 weeks after inoculation. CCL3, IL1α, CXCL1, CSF2, CSF3, IGFBP1, IL1α, IL6, IL8, CCL20, PLAUR, PlGF and VEGF were strongly up-regulated in IIB-BR-G-MTS6 compared to IIB-BR-G, while CCL4, ICAM3, CXCL12, TNFRSF18, FIGF, were the more down-regulated proteins in the metastatic cell line. IIB-BR-G-MTS6 protein expression profile was compatible with higher NF-κB activation. In vitro, IIB-BR-G displayed higher migration but IIB-BR-G-MTS6 had a higher matrigel invasion. Accordingly, IIB-BR-G-MTS6 had an up-regulated expression of MMP1, MMP9, MMP13, PLAUR and HGF as compared to IIB-BR-G. IIB-BR-G-MTS6 tumors presented higher local lymphatic invasion than IIB-BR-G but similar lymphatic vessel densities. VEGFC and VEGFA/B expression were higher both in vitro and in vivo for IIB-BR-G-MTS6. Higher vimentin expression was mainly localized in the cellular extremities in IIB-BR-G-MTS6.Our results suggest that IIB-BR-G-MTS6 have acquired an epithelial-to-mesenchymal transition phenotype, modulating tumor stroma to favor tumor growth, increase angiogenesis and promote their metastatic dissemination. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3393. doi:1538-7445.AM2012-3393
Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses
Authors: Cagan Gurer, Till Strowig, Fabienne Brilot, Maggi Pack, Christine Trumpfheller, Frida Arrey, Chae Gyu Park, Ralph M. Steinman, Christian Münz
Journal: Blood (2008)
Dichloroacetate in the Treatment of Lactic Acidosis
Authors: PETER W. STACPOOLE
Journal: Annals of Internal Medicine (1988)

An open, prospective evaluation of the effects of dichloroacetate on morbidity and survival time was done in 29 pediatric and adult patients with lactic acidosis. Dichloroacetate was administered intravenously over 30 minutes as two 50 mg/kg body weight doses separated by 2 hours. Five patients underwent retreatment with two additional drug doses and were considered new cases when analyzing for treatment response. Survival, however, was determined from the time of initial entry into the study. Patients were considered to respond to treatment if arterial lactate concentration decreased at least 20% from the pretreatment level within 6 hours of beginning the first dichloroacetate infusion. Using this criterion, 26 cases responded to therapy with dichloroacetate. For all cases, patients' mean arterial lactate concentration decreased 52% (P = 0.0009), arterial bicarbonate concentration increased 35% (P = 0.0003), and arterial pH increased (P = 0.024) to normal, defined as the range 7.35 to 7.45. Among responders, however, arterial lactate concentration decreased 74% (P = 0.0001), arterial bicarbonate level increased 47% (P = 0.0001), and arterial pH increased (P = 0.0004) to the normal range. Median survival time among responders was 60 hours, compared to 26 hours among nonresponders (P < 0.001). There was no evidence of toxicity to dichloroacetate.
Abstract 3674: Chemoprevention of endometrial cancer with urolithin A, a metabolite of berry ellagitannins.
Authors: Yi-Wen Huang, Chieh-Ti Kuo, Jibran Siddiqui, Jo-Hsin Chen, Chung-Wai Shiau, Gary D. Stoner
Journal: Cancer Research (2013)

Abstract Berries have been reported to elicit chemopreventive effects in cell culture, in animal model systems and in humans. Bio-fractionation studies indicate that the chemopreventive effects of berries can be ascribed to their component anthocyanins, ellagitannins and compounds in the non-alcohol soluble (fiber) fraction. In the present study, 17 berry-related compounds were evaluated at concentrations ranging from 1- 50 μM for their anti-proliferative effects on cultured human endometrial cancer cell lines (ECC-1, Ishikawa and HEC1A). These compounds include the anthocyanins; cyandin-3-glucoside and cyanidin-3-rutinoside and their metabolite, protocatechuic acid; ellagic acid and its metabolites, urolithins A and B; and three oligosaccharides, four short-chain carboxylic acids and four lignans present in the fiber fraction. Cell proliferation assays indicated that urolithin A was the most effective inhibitor of the growth of all three endometrial cancer cell lines. Cell cycle analysis by flow cytometry revealed that urolithin A induced cell cycle arrest at the G2/M phase. This was associated with up-regulation of the protein expression of cyclins B1 and E2, p21, phospho-cdc2 and myt1 as determined by western blot analysis. Endometrial cells depend on progesterone to limit cellular growth because it is antagonistic to estrogen-mediated cell proliferation. It is of importance therefore, that urolithin A was found to reduce estrogen receptor alpha and induce progesterone receptor expression in all three cell lines. In summary, our findings suggest that urolithin A may be chemopreventive for endometrial cancer through modulating genes that control the G2/M phase of the cell cycle and that regulate steroid receptor expression. This research was supported, in part, by MCW Startup Funds to Y-W Huang. Citation Format: Yi-Wen Huang, Chieh-Ti Kuo, Jibran Siddiqui, Jo-Hsin Chen, Chung-Wai Shiau, Gary D. Stoner. Chemoprevention of endometrial cancer with urolithin A, a metabolite of berry ellagitannins. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3674. doi:10.1158/1538-7445.AM2013-3674
Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies
Authors: Christian J. Wiedermann, Wolfgang Wiedermann, Michael Joannidis
Journal: Intensive Care Medicine (2010)

To test the hypothesis that hypoalbuminemia is independently associated with increased risk of acute kidney injury (AKI).A meta-analysis was performed of observational clinical studies evaluating the relationship between serum albumin level and the occurrence of AKI by multivariate methods. Additionally, the impact was assessed of lower serum albumin on mortality in patients who developed AKI. Eligible studies were sought by multiple methods, and adjusted odds ratios (OR) were quantitatively combined using a random effects model.Seventeen clinical studies with 3,917 total patients were included: 11 studies (6 in surgical or intensive care unit patients and 5 in other hospital settings) evaluating the influence of serum albumin on AKI incidence and 6 studies describing the relationship between serum albumin and mortality among patients who had developed AKI. Lower serum albumin was an independent predictor both of AKI and of death after AKI development. With each 10 g L(-1) serum albumin decrement, the odds of AKI increased by 134%. The pooled OR for AKI was 2.34 with a 95% confidence interval (CI) of 1.74-3.14. Among patients who had developed AKI, the odds of death rose 147% (pooled OR 2.47, 95% CI 1.51-4.05) with each 10 g L(-1) serum albumin decrement.This meta-analysis provides evidence that hypoalbuminemia is a significant independent predictor both of AKI and of death following AKI development. Serum albumin determinations may be of utility in identifying patients at increased risk for AKI or for death after AKI. Controlled studies are warranted to assess interventions aimed at correcting hypoalbuminemia.
Both early-onset and late-onset ventilator-associated pneumonia are caused mainly by potentially multiresistant bacteria
Authors: Elpis Giantsou, Nikolaos Liratzopoulos, Eleni Efraimidou, Maria Panopoulou, Eleonora Alepopoulou, Sofia Kartali-Ktenidou, George I. Minopoulos, Spyros Zakynthinos, Konstantinos I. Manolas
Journal: Intensive Care Medicine (2005)
Acute Epidural Abscess
Authors: W. R. D. Mitchell
Journal: BMJ (1938)

MEDICAL JOURNALthat in the control group many of the throat infections were due to organisms other than haemolytic streptococci, or that the carrier condition after faucial infection was less persistent than in rheumatic subjects.Regarding the Lancefield grouping of the isolated strains, it was interesting to find that 87 per cent. of those from rheumatic subjects were of the important pathogenic Group A, whereas only 42 per cent. of strains from controls were of this type.Nevertheless even in the control group the majority of carrier strains from persons with a definite history of recent infection were also members of Group A. Conclusions 1.Of a group of 200 subjects with acute rheumatic manifestations 78 per cent.gave a history of antecedent throat infections; 46 per cent. of a non-rheumatic control group gave a similar history.2. Throat swab cultures for haemolytic streptococci were positive in 58 per cent.and 30 per cent. of the rheumatic and control groups respectively.3. Of the strains of haemolytic streptococci from throat swabs of rheumatic subjects 87 per cent.were serologically classified in Lancefield Group A; 42 per cent. of strains from non-rheumatic controls were of this group.Group A strains were therefore isolated from 50.5 per cent.and 12.5 per cent. of the rheumatic and control groups.4. The evidence supports the relationship between infec- tion with haeemolytic streptococci and the rheumatic state.1 am indebted to the physicians of the Royal Hospital for Sick Children, the Royal Infirmary, and the Municipal City Hospitals of Edinburgh for granting access to cases under their charge.It is a real pleasure to acknowledge the co- operation of Dr. John G. Sclater in the collection of specimens.
Abstract 2713: Association of HBV/inflammation and stemness expression in HBV-related HCC recurrence
Authors: Te-Sheng Chang, Kam-Fai Lee, Hsin-Yi Lin, Shui-Yi Tung, Liang-Mou Kuo, Xin-Wei Jen, Yen-Hua Huang
Journal: Cancer Research (2011)

Abstract Hepatocellular carcinoma associated with chronic HBV hepatitis (HBV-HCC) tends to have a poorer prognosis. Inflammation is a common and strong participant in the development of HBV-HCC. However, the mechanism of HBV/inflammation-induced hepatocarcinogenesis still remains largely unknown. Here we demonstrate the potential synergistic role of HBV and proinflammatory cytokines in stemness expression which might associate with HBV-HCC recurrence. In this study, human HCC cell lines including HBV- HCC cells (HepG2.2.15, PLC5, Hep3B, and HA22T), and non-HBV HCC cells (HepG2 and Huh 7) were cultivated with inflammation condition medium (inflam-CM). Inflam-CM significantly increased the expression levels of pluripotent transcription factors (Oct-4, Sox2, and Nanog) and the percentage of side population cells in HBV-HCC but less or not in non-HBV HCC. Furthermore, flow-cytometry and epifluorescence analysis showed that inflam-CM markedly increased the GFP+ cell population in Oct-4 promoter-GFP-HepG2.2.15 cells but not in Oct-4 promoter-GFP-HepG2 cells, supporting the synergistic effect of proinflammatory cytokines and HBV in Oct-4 expression. To test the role of stemness expression in HCC prognosis, HA-Oct-4-HepG2 (HepG2 cells over-expressing HA-Oct-4) were used for drug sensitivity and migration/invasion assay. HA-Oct-4 HepG2 cells showed higher drug resistance and migration/invasion ability comparing with HepG2 cells. The responsible proinflammatory cytokines were to be identified using specific neutralizing antibodies and/or signaling inhibitors. The clinical impact was further analyzed using human HCC frozen tissues and tissue blocks which were collected under IRB approval. Real-time quantitative PCR analysis of HCC frozen tissues (N = 102) revealed a significant difference between HBV-HCC and HCV-HCC for the expression of Oct-4 (p=0.0089), Nanog (p=0.0021) and disease-free interval (DFI) (p&amp;lt;0.001). Immunohistochemical staining of HCC tissue blocks (N = 33) further confirmed the strong correlation between stemness expression (Oct-4 and Nanog) and short DFI. In summary, proinflammatory cytokines and HBV may work collaboratively to activate the stemness expression which results in early HBV-HCC recurrence. This finding characterizes a potential target for adjuvant therapy against HBV-HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2713. doi:10.1158/1538-7445.AM2011-2713
Alterations in Cardiac Synchrony Induced by the Cardiac Sympathetic Nerves
Authors: Donald V. Priola, Walter C. Randall
Journal: Circulation Research (1964)

While pressures were recorded separately from the four chambers of the heart in openchest dog preparations, together with a standard limb lead of the ECG, the right and left stellate ganglia were stimulated. Measurements from the beginning of the P wave to the initial rise in chamber pressures revealed that pressure in the left ventricle began to rise approximately 20 msec prior to that in the right ventricle. This interval was significantly shortened during electrical stimulation of the stellate ganglion. Although the interval between P wave and the initial pressure elevations in the right atrium (RA) and the left atrium (LA) both shortened during stellate stimulation, P-RA decreased considerably more than P-LA. The P wave, PR interval, and the QRS complex all shortened markedly, indicating increased conduction velocity over the atria, the nodal conducting tissue, and the ventricles during stellate stimulation. These events occurred with or without alterations in heart rate and were correlated with large increases in the rate of change of ventricular pressures. Simple algebraic summation of individual muscle segment contractions may achieve significantly greater intraventricular pressure as the contractions become more synchronous. The total pressure developed is further augmented when each individual unit contracts with greater force and greater velocity. The recruitment of additional functional units would result in further summation and thus in still greater augmentation in total force and pressure. Alterations in pacemaker site are common during stellate stimulation.
Pseudo-dermatomyositis induced by long-term hydroxyurea therapy: report of two cases
Authors: P. Bahadoran, J. Castanet, J.PH. Lacour, C. Perrin, P. del
           Giudice, N. Mannocci, J.G. Fuzibei, J.P. Ortonne
Journal: British Journal of Dermatology (1996)

Journal Article Pseudo‐dermatomyositis induced by long‐term hydroxyurea therapy: report of two cases Get access P. Bahadoran, P. Bahadoran Department of Dermatology, University of Nice, France Search for other works by this author on: Oxford Academic Google Scholar J. Castanet, J. Castanet Department of Dermatology, University of Nice, France Search for other works by this author on: Oxford Academic Google Scholar J.PH. Lacour, J.PH. Lacour Department of Dermatology, University of Nice, France Search for other works by this author on: Oxford Academic Google Scholar C. Perrin, C. Perrin Department of Pathology, University of Nice, France Search for other works by this author on: Oxford Academic Google Scholar P. del Giudice, P. del Giudice Department of Dermatology, University of Nice, France Search for other works by this author on: Oxford Academic Google Scholar N. Mannocci, N. Mannocci Department of Dermatology, University of Nice, France Search for other works by this author on: Oxford Academic Google Scholar J.G. Fuzibei, J.G. Fuzibei Department of Internal Medicine, University of Nice, France Search for other works by this author on: Oxford Academic Google Scholar J.P. Ortonne J.P. Ortonne Department of Dermatology, University of Nice, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 6, 1 June 1996, Pages 1161–1162, https://doi.org/10.1111/j.1365-2133.1996.tb07975.x Published: 01 June 1996