tbuckley/cabot-search huggingface dataset:
Crystallocryoglobulinemia Resulting from Human Monoclonal Antibodies to Albumin
Authors: LETHA E. MILLS
Journal: Annals of Internal Medicine (1983)

Two patients had a previously unrecognized form of crystallocryoglobulinemia. Their clinical presentations were similar, consisting of necrotizing vasculitis and purpura involving the legs. Analysis of each cryoglobulin complex showed that two components, albumin and a monoclonal IgG-lambda, were present, and both components were needed in a fixed ratio for precipitation. In addition, cryoprecipitation occurred in serum, but not plasma, due to citrate inhibition of complex formation. Our findings suggest that the monoclonal IgGs have the properties of antibodies directed specifically against a calcium-dependent antigenic site on human albumin, and that the resultant IgG-lambda-albumin immune complexes crystallized in the cold.
Abstract 5150: FJX1 is an important mediator of tumor biology due, in part, to its effect ontumor vascularization
Authors: Nicole Al-Greene, Pengcheng Lu, Jinghuan Zi, Aixiang Jiang, Yu Shyr, Natasha Deane, R. Daniel Beauchamp
Journal: Cancer Research (2011)

Abstract The underlying mechanisms responsible for tumor vascularization, often correlating with poor prognosis, are an important area of cancer research. We identified Four jointed box 1 (fjx1) as a candidate gene for regulating tumor vascularization in colorectal cancer (CRC) as it was inhibited in rectal cancers (n=16) after one week treatment with Celebrex. We hypothesized that FJX1 contributes to malignant cellular behavior by enhancing tumor vascularization. Using microarray data from 255 CRC patients we determined relative fjx1 mRNA expression levels across normal, adenoma, and stages I-IV CRC. Data were validated using quantitative RT-PCR on selected patient samples. Patients were segregated as having lower or higher than median fjx1 expression and Kaplan-Meier survival estimates were derived. Biological function was tested by overexpressing Myc-tagged human FJX1 protein in various cell lines (HEK293T, YAMC, SW480) and subjecting them to invasion and proliferation assays in vitro. SW480 derivatives were also used for flank injections to assess tumorigenesis in vivo. Tumors were analyzed via immunohistochemistry for markers of proliferation, apoptosis, and endothelial cells. Finally, conditioned media from SW480 derivatives was used in vitro to test the effects on endothelial cell (HMEC-1) invasion and tube formation. Microarray expression data from our 255 CRC patient data set showed that fjx1 mRNA is elevated in all stages of CRC as compared to normal/adenoma tissue. Higher expression of fjx1 relative to the median was associated with significantly worse overall patient survival (p=0.0125). Elevated mRNA expression from tumor samples as compared to normal was validated by qRT-PCR within a subset of patients. Over-expression of fjx1 in HEK293T, YAMC, and SW480 cells increased invasion in vitro without altering cell proliferation. Conditioned media from SW480FJX1 cells promoted endothelial tube formation and invasion in vitro as compared to conditioned media from SW480VEC. Using an angiogenesis array and ELISA we identified and confirmed that VEGF was upregulated in SW480FJX1 conditioned media as compared to SW480VEC. Finally SW480FJX1 cells were more tumorigenic than SW480VEC in vivo, in association with increased proliferation, vascularization, and decreased apoptosis. Taken together our results support our hypothesis that FJX1 is an important mediator of tumor biology due, in part, to its effect on tumor vascularization. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5150. doi:10.1158/1538-7445.AM2011-5150
Erythropoietic Protoporphyria—A Fatal Case
Authors: E. M. Donaldson
Journal: British Journal of Dermatology (1969)

Journal Article Erythropoietic Protoporphyria—A Fatal Case Get access E. M. Donaldson E. M. Donaldson Department of Dermatology, North Staffordshire Hospital Centre Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 12, 1 December 1969, Pages 945–946, https://doi.org/10.1111/j.1365-2133.1969.tb15982.x Published: 01 December 1969
748 LACK OF SUSTAINED VIROLOGICAL RESPONSE TO ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C IS ASSOCIATED WITH A SIGNIFICANT RISK OF PROGRESSION TO CIRRHOSIS
Authors: S.M. Martinez, N. Tesei, E. Martinez-Bauer, S. Ampurdanes, J.M. Barrera, M. Bruguera, J.M. Sanchez-Tapias, X. Forns
Journal: Journal of Hepatology (2008)
Abnormal perception of food size in anorexia nervosa
Authors: P M Yellowlees, M Roe, M K Walker, D I Ben-Tovim
Journal: BMJ (1988)

The hypothesis that patients with anorexia nervosa exaggerate the perceived size of food was tested. Video recordings of five items of food and four neutral objects of a similar size were made such that the size of each object increased steadily from half to twice its normal size. Each of the nine objects was placed on a ledge inside a dummy television screen next to the video screen, the food items alternating with the neutral objects, and 20 female patients with anorexia nervosa and 20 female controls matched for age were asked to adjust the size of the video recording to that of the real object. Although there was no overall difference in perceptual accuracy between patients and controls, both groups perceived the food items as being bigger than the neutral objects, the patients exaggerating the size of the food significantly more than the controls. These results imply that patients with anorexia might start eating more easily when admitted if their food were presented as small portions on large plates.
Erythermalgia
Authors: RICHARD R. BABB, DONATO ALARCON-SEGOVIA, JOHN F. FAIRBAIRN
Journal: Circulation (1964)

The syndrome of erythermalgia is characterized by a burning distress of the extremities that is accompanied by redness and increased temperature of the skin. These symptoms are initiated or exacerbated by an increase in environmental temperature and diminished by measures that cool the skin. Of 51 patients with this clinical syndrome seen at the Mayo Clinic during the years 1951 to 1960 inclusive, 30 were considered as having primary erythermalgia because of the absence of demonstrable associated conditions, and the rest were classified as having secondary erythermalgia because the condition was associated with various diseases. Particularly significant was the relation of erythermalgia to the myeloproliferative disorders as evidenced in 10 cases. In some of these cases, erythermalgia preceded other manifestations of the myeloproliferative disorder by as long as 12 years. The primary type was found to occur in younger individuals and to be more often bilateral, to produce pain of greater intensity, and to involve larger areas of the affected extremities. The pathologic physiology of this syndrome remains unknown.
A CASE OF LOCOMOTOR ATAXIA WITH A TREMOR RESEMBLING THAT OF PARALYSIS AGITANS.
Authors: JOHN H. W. RHEIN
Journal: JAMA (1905)

At a session of the American Medical Association in June, 1902, I reported three cases of involuntary movements in ataxia. Since that time one of these patients has died, and I was fortunate enough to obtain an autopsy. The case was one in which a tremor of both arms existed from the early stages of the disease. This tremor was like that of paralysis agitans. <h3>Patient.</h3> —A man, aged 57; family history good. He himself had always been healthy, having never had any serious illness of any sort, and has always been temperate in alcohol and tobacco. <h3>History.</h3> —In 1883 he contracted syphilis. The first tabetic symptoms consisted of the characteristic pains of ataxia, from which he suffered for nine years before the other symptoms of the disease made their appearance. Then there gradually developed numbness of the hands, unsteadiness in walking, and the tremor in both hands
Exporting US Postgraduate Fellowship Training Overseas
Authors: Paul P. L. Chang
Journal: JAMA (1989)

In 1984, cancer surpassed cerebrovascular disease as the number one cause of death in Taiwan, with a total of 17 983 new cases reported—an incidence of 95.29 per 100 000 population. The leading site for cancer in men was the lung, and the leading site for women was the uterine cervix.<sup>1</sup>That year there were 13 383 registered physicians practicing western medicine and 1799 practitioners of traditional Chinese medicine, which include herbists, acupuncturists, and bone setters (unpublished data, Taiwan Provincial Health Dept and Taipei City and Kaohsiung City Health Departments, 1989). For Taiwan, an island of about 20 million people, the medical care of cancer patients has been provided by physicians of almost every specialty. This situation is similar to that which existed in the United States in the 1950s and 1960s before the advent of efficacious chemotherapeutic agents and the establishment of medical oncology as a subspecialty. In
Identification and cloning of a complementary DNA encoding a vicilin-like proprotein, Jug r 2, from English walnut kernel (Juglans regia), a major food allergen☆☆☆★★★
Authors: S S Teuber, K C Jarvis, A M Dandekar, W R Peterson, A A Ansari
Journal: Journal of Allergy and Clinical Immunology (1999)
Asthma, Steroids, and Growth
Authors: Mary Ellen B. Wohl, Joseph A. Majzoub
Journal: New England Journal of Medicine (2000)

Long-term administration of systemic corticosteroids is a cause of impaired growth.1 Trials comparing inhaled corticosteroid preparations with other treatment regimens in nearly 600 children with asthma found that inhaled beclomethasone had greater therapeutic effect than did other regimens.25 In the studies, each of which lasted about one year, children treated with inhaled corticosteroids had less growth in height (1 to 1.6 cm [23 to 27 percent] less) than those assigned to other treatments. The mechanisms by which this delay in growth occurs are unknown. If inhaled corticosteroids are not discontinued, does growth suppression continue, so that children with asthma . . .
Chronic Lymphocytic Leukemia
Authors: ROBERT PETER GALE
Journal: Annals of Internal Medicine (1985)

Chronic lymphocytic leukemia is a hematologic neoplasm characterized by proliferation and accumulation of mature-appearing lymphocytes. Most cases involve a clonal proliferation of B lymphocytes. The cells typically have low levels of surface immunoglobulin; usually mu or mu and delta heavy chains, and either kappa or lambda light chains. The cells also show receptors for mouse erythrocytes, Fc receptors for lgG, complement receptors, la antigens, and B-cell-associated antigens. Although chronic lymphocytic leukemia is usually a stable disease over months to years, transformation of both clinical and biological features may occur. Prognostic factors include the leukemia cell count (greater than 40 X 109/L), anemia, thrombocytopenia, chromosome abnormalities, and the pattern of bone marrow involvement. Alkylating agents, radiation therapy, and corticosteroids are commonly used to treat patients with chronic lymphocytic leukemia. Although these agents are useful, few data show that survival has been substantially improved. Recently, biological response modifiers such as monoclonal antibodies and interferon have been studied.
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
Authors: Takeshi Sakurai, Ruby Nagata, Akihiro Yamanaka, Hiroko Kawamura, Natsuko Tsujino, Yo Muraki, Haruaki Kageyama, Satoshi Kunita, Satoru Takahashi, Katsutoshi Goto, Yoshimasa Koyama, Seiji Shioda, Masashi Yanagisawa
Journal: Neuron (2005)
An unusual ectodermal dysplasia with unique eye defects
Authors: V.A. Hill, K.K. Nischal, J.R.O. Collin, J.I. Harper
Journal: British Journal of Dermatology (2005)

Journal Article An unusual ectodermal dysplasia with unique eye defects Get access V.A. Hill, V.A. Hill Consultant Dermatologist, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, U.K. *Consultant Ophthalmologist, Great Ormond Street Hospital, London, U.K. †Consultant Ophthalmologist, Moorfields Eye Hospital, London, U.K. ‡Consultant in Paediatric Dermatology, Great Ormond St. Hospital, London, U.K Dr Virginia A. Hill. E‐mail: virginia.hill@bch.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar K.K. Nischal, K.K. Nischal Consultant Dermatologist, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, U.K. *Consultant Ophthalmologist, Great Ormond Street Hospital, London, U.K. †Consultant Ophthalmologist, Moorfields Eye Hospital, London, U.K. ‡Consultant in Paediatric Dermatology, Great Ormond St. Hospital, London, U.K Search for other works by this author on: Oxford Academic Google Scholar J.R.O. Collin, J.R.O. Collin Consultant Dermatologist, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, U.K. *Consultant Ophthalmologist, Great Ormond Street Hospital, London, U.K. †Consultant Ophthalmologist, Moorfields Eye Hospital, London, U.K. ‡Consultant in Paediatric Dermatology, Great Ormond St. Hospital, London, U.K Search for other works by this author on: Oxford Academic Google Scholar J.I. Harper J.I. Harper Consultant Dermatologist, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, U.K. *Consultant Ophthalmologist, Great Ormond Street Hospital, London, U.K. †Consultant Ophthalmologist, Moorfields Eye Hospital, London, U.K. ‡Consultant in Paediatric Dermatology, Great Ormond St. Hospital, London, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 2, 1 February 2005, Pages 365–367, https://doi.org/10.1111/j.1365-2133.2004.06366.x Published: 01 February 2005 Article history Accepted: 26 April 2004 Published: 01 February 2005
Doctors object to patients access to notes
Authors: C. Zinn
Journal: BMJ (2001)

The Australian Medical Association is fighting plans by the federal privacy commissioner to make doctors surrender all their medical records to patients who demand them within 30 days and at no cost.

The association wants some parts of the notes to remain beyond the scope of the draft guidelines for the new privacy laws, claiming that they are the doctors' intellectual property and if viewed independently could cause anxiety.

The association's president, Dr Kerryn Phelps, said there were two levels of medical records, and she had no problem with doctors …
Adult and Pediatric Medulloblastomas Are Genetically Distinct and Require Different Algorithms for Molecular Risk Stratification
Authors: Andrey Korshunov, Marc Remke, Wiebke Werft, Axel Benner, Marina Ryzhova, Hendrik Witt, Dominik Sturm, Andrea Wittmann, Anna Schöttler, Jörg Felsberg, Guido Reifenberger, Stefan Rutkowski, Wolfram Scheurlen, Andreas E. Kulozik, Andreas von Deimling, Peter Lichter, Stefan M. Pfister
Journal: Journal of Clinical Oncology (2010)

Medulloblastoma (MB) is the most common malignant brain tumor in children, whereas it rarely presents in adults. We aimed to identify genetic aberrations in 146 adult MBs to evaluate age-dependent differences in tumor biology and adapt age-specific risk stratification models.As a screening set, we studied a cohort of 34 adult MBs by using array-based comparative genomic hybridization comparing molecular results with clinical data. DNA copy number aberrations identified as possible prognostic markers were validated in an independent cohort of 112 adult patients with MB by fluorescent in situ hybridization analysis. Results were compared with the data obtained from 404 pediatric patients with MB.CDK6 amplification, 10q loss, and 17q gain are the most powerful prognostic markers in adult MB. Whereas MYC/MYCN oncogene amplifications had a high prognostic value in pediatric MB, these aberrations were rarely observed in adult tumors. Surprisingly, adult MBs with 6q deletion and nuclear beta-catenin activation did not share the excellent prognosis with their pediatric counterparts.Adult MB is distinct from pediatric MB in terms of genomic aberrations and their impact on clinical outcomes. Therefore, adult MBs require age-specific risk stratification models. We propose a molecular staging system involving three distinct risk groups based on DNA copy number status of 10q and 17q.
Endoscopic Resection of Rectal Carcinoid Tumors Using Aspiration Lumpectomy
Authors: Y. Imada-Shirakata, M. Sakai, T. Kajiyama, G. Kin, K. Inoue, A. Torii, H. Kishimoto, S. Ueda, M. Okuma
Journal: Endoscopy (1997)

Although carcinoid tumors have malignant potential, complete resection can be curative if the lesion is located within the submucosal layer. In this study, we evaluated the effectiveness of endoscopic aspiration lumpectomy for the treatment of small rectal carcinoid tumors.Eight patients with rectal carcinoid tumors less than 10 mm in diameter and located within the submucosa were treated by aspiration lumpectomy. It was confirmed that none of the patients had any metastatic lesions before treatment. The procedure was carried out using an endoscope with a cylinder attached to the tip and a Teflon tube along its outer axis. The lesion was aspirated into the cylinder, grasped by a snare passed through the tube, and then resected.All lesions were excised completely, without any complications. The resected specimens were circular, with the lesions located in the center of the surrounding mucosa. The diameter of the specimens (mean +/- SD) was 18.3 +/- 6.2 mm. All tumors were histologically typical, and the lateral and bottom margins of the specimens were free of tumor cells. No recurrences or distant metastases were found in any of the patients during the mean observation period of 13.3 months.We conclude that aspiration lumpectomy is a useful and safe technique for the treatment of small rectal carcinoid tumors contained within the submucosa.
Isolation and characterization of an aetiological agent in Whipple's disease.
Authors: R L Clancy, W A Tomkins, T J Muckle, H Richardson, W E Rawls
Journal: BMJ (1975)

A cell wall deficient form of an alpha-haemolytic streptococcus was grown from a prolonged monolayer cell culture of a lymph node taken from a patient with Whipple's disease. Serological cross reactivity was shown between the organism and the material within Whipple's disease macrophages positive for diastase-resistant periodic acid-Schiff (D./P.A.S.). In vitro studies characterized the organism as a facultative intracellular parasite which caused the accumulation within cells of D./P.A.S.-positive material. These results suggest that a pathogenic bacterium is the essential aetiological agent and that the culture of Whipple's disease tissues in hypertonic media may have practical value.
Wiskott–Aldrich syndrome with partial response to transfer factor
Authors: RONA M. MACKIE, M. J. ALCORN, R. D. STEVENSON, T. COCHRAN, R. N. M. McSWEEN
Journal: British Journal of Dermatology (1978)

Journal Article Wiskott–Aldrich syndrome with partial response to transfer factor Get access RONA M. MACKIE, RONA M. MACKIE University Department of Dermatology, Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar M. J. ALCORN, M. J. ALCORN University Department of Pathology, Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar R. D. STEVENSON, R. D. STEVENSON Centre for Respiratory Investigation, Glasgow Royal Infirmary, Heathfield Hospital, Ayr Search for other works by this author on: Oxford Academic Google Scholar T. COCHRAN, T. COCHRAN Department of Dermatology, Heathfield Hospital, Ayr Search for other works by this author on: Oxford Academic Google Scholar R. N. M. McSWEEN R. N. M. McSWEEN University Department of Pathology, Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 98, Issue 5, 1 May 1978, Pages 567–571, https://doi.org/10.1111/j.1365-2133.1978.tb01944.x Published: 01 May 1978
957-112 The Incidence and Clinical Implication of Acute Hemorrhagic Myocardial Infarction Detected by MRI
Authors: Kouichi Ochiai, Jun Kitamura, Hironori Tsukihashi, Yutaka Ishibashi, Yo Murakami, Kazuya Sano, Toshio Shimada, Shigefumi Morioka, Hideaki Kawamitsu, Kazuro Sugimura
Journal: Journal of the American College of Cardiology (1995)
Insuring the Uninsured
Authors: Kevin Grumbach
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medic, Candy-Maker, Or Grapejuice?
Authors: John R. F. Richardson
Journal: JAMA (1966)

<h3>To the Editor:—</h3> My secretary is very proud of her Welsh heritage. I told her that I would write to you to say that she is very indignant at your spelling of "Welshman" on the cover of the May 16 issue of your magazine.
The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides*
Authors: Eduardo A. Nillni, Kevin A. Sevarino
Journal: Endocrine Reviews (1999)

I. Introduction II. Biosynthesis of TRH and Other pro-TRH-Derived Peptides A. Biosynthesis and processing of pro-TRH B. Intracellular sites of pro-TRH processing C. Tissue-specific processing of pro-TRH D. The role of PCs and CPs E. Neuropeptide and catecholamine regulation of Pro-TRH biosynthesis and processing F. Glucocorticoids modulate the biosynthesis and processing of pro-TRH G. Leptin regulates pro-TRH biosynthesis III. Function of TRH A. The HPT axis B. Extrahypophysiotropic TRH IV. Function of non-TRH pro-TRH-Derived Peptides A. prepro-TRH160–169 (pST10) B. prepro-TRH178–199 (pFE22) C. prepro-TRH178–185 and prepro-TRH186–199 (pFQ7 and pSE14) D. prepro-TRH53–74 (pFT22) E. prepro-TRH83–106 (pEH24) and prepro-TRH208–255 F. TRH-Gly V. Non-TRH pro-TRH-Derived Peptides Outside of the CNS VI. TRH and Other pro-TRH-Derived Peptide Receptors A. The TRH receptor B. The prepro-TRH160–169 (pST10) receptor VII. TRH Degradation VIII. Concluding Remarks
Patients With Sensation of a Rectal Mass
Authors: Walter Birnbaum
Journal: JAMA (1980)

To the Editor.—  The question concerning the cause of a sensation of a mass in the rectum in a 44-year-old woman was submitted to two authorities (242:1785, 1979) whose answers were (1) a mass within or outside the rectum (although there was no demonstrable evidence of a mass), (2) nerve root compression, (3) rectal prolapse, and (4) functional disorder. While these conditions may, indeed, be unusual causes of the complaint in question, the most common pathogenesis is the so-called levator syndrome from tonic spasm of the puborectalis, pubococcygeus, and piriformis muscles, so well described by Thiele. 1   The levator syndrome may consist of episodic pain, fullness, and pressure in the rectum and sacrococcygeal area, often aggravated by sitting. Some patients describe only a sensation of an intrarectal object. A variant of the syndrome is sharp rectal pain, sometimes awakening the person at night (proctalgia fugax). Coccygodynia (pain in the coccyx)