tbuckley/cabot-search huggingface dataset:
Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225
Authors: K.J. Busam, P. Capodieci, R. Motzer, T. Kiehn, D. Phelan, A.C. Halpern
Journal: British Journal of Dermatology (2001)

C225 is an antibody to the epidermal growth factor receptor (EGFR), and inhibits growth of various tumour cells. The antibody is currently being used as a therapeutic agent in several clinical trials of patients with carcinomas. Objectives To determine and investigate the cutaneous side-effects in cancer patients treated with C225. Methods We clinically examined 10 patients treated with C225, and performed immunohistochemical and in situ hybridization studies on skin biopsies. Results The most common cutaneous reaction to C225 therapy was the development of an acneiform follicular eruption, which was most pronounced on the face, chest and upper back and typically manifested a week after the onset of treatment. The consistency of the morphology and timing of the clinical findings in 10 different patients following monotherapy with C225 strongly suggested a direct biological effect of the antibody. Additional dermatological side-effects included focal areas of tender paronychial inflammation of toes and fingers and small aphthous ulcers of the oral mucosa. Serial punch biopsies of chest skin before and after treatment (at 8 days) revealed two main reaction patterns: a superficial dermal inflammatory cell infiltrate surrounding hyperkeratotic and ectatic follicular infundibula, and a suppurative superficial folliculitis. In two biopsies focal intraepidermal acantholysis was found. Microbiological cultures failed to reveal an infectious aetiology. Immunohistochemical and in situ hybridization studies on a subset of the biopsies showed an increase in the expression of p27Kip1 in epidermal keratinocytes after treatment with C225. Conclusions Our findings support the concept that p27Kip1 plays a part in the in vivo regulation of follicular and epidermal homeostasis by EGFR.
Don't forget eclampsia
Authors: J. C. Girling
Journal: BMJ (2014)

In her review of first seizures, Angus-Leppan fails to mention eclampsia, an important cause of tonic-clonic seizures, which has a unique management pathway.1 She rightly emphasises the importance of taking a good history to establish whether a seizure has happened and lists some important diagnostic blood tests. However, healthcare professionals also need to think …
"Sore Throat" in General Practice
Authors: J. B. Landsman, N. R. Grist, R. Black, D. McFarlane, W. Blair, T. Anderson
Journal: BMJ (1951)

SULPHONAMIDES AND ACUTE TONSILLITIS BDICA ¶ORNAL was, however, able to make an estimate of "goodness of cure" which had a significant relationship to administration of sulphatriad.It is felt that the routine administration of sulphonamides to patients with acute tonsillitis cannot be supported by the results of this experiment.We wish to thank Professor Bradford Hill and Dr. D. D. Reid for their help and advice.
Intense Transference Reactions and the Group Therapist
Authors: B.B. Fielding
Journal: Psychotherapy and Psychosomatics (1966)

Research Articles| February 11 2010 Intense Transference Reactions and the Group Therapist Subject Area: Psychiatry and Psychology B.B. Fielding B.B. Fielding Group Therapy Department, Post Graduate Center for Mental Health, New York City Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1966) 14 (3): 161–170. https://doi.org/10.1159/000285821 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation B.B. Fielding; Intense Transference Reactions and the Group Therapist. Psychother Psychosom 1 March 1966; 14 (3): 161–170. https://doi.org/10.1159/000285821 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Fayez Nazeer Botros
Authors: M. Fitzpatrick
Journal: BMJ (2010)

The ability to predict the timing of forthcoming events, known as temporal expectation, has a strong impact on human information processing. Although there is growing consensus that temporal expectations enhance the speed and accuracy of perceptual decisions, it remains unclear whether they affect the decision process itself, or non-decisional (sensory/motor) processes. Here, healthy human participants (<i>N</i> = 21; 18 female) used predictive auditory cues to anticipate the timing of low-contrast visual stimuli they were required to detect. Modeling of the behavioral data using a prominent sequential sampling model indicated that temporal expectations speeded up non-decisional processes but had no effect on decision formation. Electrophysiological recordings confirmed and extended this result: temporal expectations hastened the onset of a neural signature of decision formation but had no effect on its build-up rate. Anticipatory α band power was modulated by temporal expectation and co-varied with intrinsic trial-by-trial variability in behavioral and neural signatures of the onset latency of the decision process. These findings highlight how temporal predictions optimize our interaction with unfolding sensory events. <b>SIGNIFICANCE STATEMENT</b> Temporal expectation enhances performance, but the locus of this effect remains debated. Here, we contrasted the two dominant accounts: enhancement through (1) expedited decision onset, or (2) an increase in the quality of sensory evidence. We manipulated expectations about the onset of a dim visual target using a temporal cueing paradigm, and probed the locus of the expectation effect with two complementary approaches: drift diffusion modeling (DDM) of behavior, and estimation of the onset and progression of the decision process from a supramodal accumulation-to-bound signal in simultaneously measured EEG signals. Behavioral modeling and neural data provided strong, converging evidence for an account in which temporal expectations enhance perception by speeding up decision onset, without affecting evidence quality.
Results of Radium Treatment of Carcinoma
Authors: W. F. Shaw, D. Dougal
Journal: BMJ (1936)

THBRITTS.a routine.Two cases, however, are worthy of mention.One, a male aged 61, who had an attack of coronary thrombosis in London, and was examined-by Dr. Parkinson, has done well on iodides and mercury.The other, a young man of 32 who had contracted syphilis six years previously, has also done well on the same treatment. Coronary Throm6osis and DiabetesThough the frequency with which coronary thrombosis and diabetes are associated is attributed to degenerative vascular changes, one has to remember that in diabetes acute and chronic infections are a frequent source of worry and danger.Morris Enklewitz24 found that coronary thrombosis occurred twice as frequently in diabetics as in non-diabetic patients, and other writers have had similar findings.While two of my cases with blood sugars' of 0.244 and 0.345 at the time of the attack of coronary thrombosis would fit in with the degenerative vascular changes being the prime cause of the occlusion, a third case would seem to point to an infective agency being superadded to the vascular degeneration.This was a married woman of 43 with a history of previous good health till three years ago, when she had a large carbuncle on her back.Since then she had had polyuria and thirst, but did not consult her doctor until a few days before her admission to hospital.Her urine was loaded with sugar and acetone, but with insulin and diet both urine and blood became normal, and she was due to be discharged from hospital.The evening before she was to go home she was seized with a severe pain in the chest, and died in a fewv minutes.A post-mortem examination showed that her death was due to a coronary thrombosis.Clinically this patient showed no evidence of any vascular degenerative changes. SummaryThe cases I have mentioned are only a few picked out to demonstrate the fact that concurrent .orprevious infec- tions are found in many cases of coronary thrombosis, and more cases could be quoted bearing out the same intimate relationship.It is difficult to prove that these infections are the determining cause of the severe cardiac lesion, but the fact that lesions such as those of the gall-bladder are found makes it essential that everything possible should be done to eliminate any focal infection, in the hope that a cardiac tragedy may be averted.
Television Violence — Reactions from Physicians, Advertisers and the Networks
Authors: Murray Feingold, G. Timothy Johnson
Journal: New England Journal of Medicine (1977)

In response to our call for letters on television violence we received more than 1500 letters from readers of the Journal. Seventy-two per cent of the leading television advertisers responded to a subsequent letter requesting a description of their policies regarding content of the programs they sponsor. Their responses included exculpating factors such as lack of control over programming, the limited amount of available advertising time and censorship. We presented these responses to network representatives. They commented on the difficulty in defining violence, the current decrease in the amount of violence shown and their activities in response to this issue. We maintain that the burden of proof that television violence does not harm lies with those who introduce it into society. Advertisers and networks will respond, we believe, to the problem of television violence if continuous public pressure is maintained.
Extradition bid is likely after findings against doctor
Authors: Bob Burton
Journal: BMJ (2005)

The Queensland government is seeking the voluntary return or extradition of Dr Jayant Patel after a commission of inquiry investigating his employment and performance at Bundaberg Base Hospital, Bundaberg, in central Queensland, recommended that criminal charges be laid against him ( BMJ 2005;330:985, 30 Apr).

An appeal by Queensland's attorney general, Rod Welford, that Dr Patel return voluntarily to respond to allegations against him has been rebuffed by his lawyers. One of Dr Patel's legal team in Australia, Damien Scattini, ruled out his return from the United States in the absence of any criminal …
“Race Correction” in Pulmonary-Function Testing
Authors: Paul D. Scanlon, Mark D. Shriver
Journal: New England Journal of Medicine (2010)

Tests of pulmonary function and radiographic imaging of the chest are the two key methods used in diagnostic evaluation of patients with pulmonary disease. Unlike blood pressure, acceptable normal values vary from person to person and from one demographic group to another. The first studies, in 1846, of spirometric assessment of forced vital capacity (FVC), the most basic pulmonary-function test, showed that normal values for vital capacity vary as a function of height and age.1 A few years later, it was shown that vital capacity was 6 to 12% lower in healthy black soldiers than in white or Native American . . .
A NEW SEPTOTOME.
Authors: WALTER A. WELLS
Journal: JAMA (1905)

This instrument is designed to be used as a substitute for the knife or scissors in cases of uncomplicated deviation of the cartilaginous septum. It cuts out of the cartilaginous portion of the septum a more or less tongue-shaped flap, and it accomplishes with a single incision at least as much as is done in the Asch operation with two separate incisions. Thus is overcome the necessity of removing one set of scissors to substitute another, which may prove a serious drawback in case one is operating on a nervous patient under a local anesthetic. In the Asch operation, the result of the incisions is to create four small, triangular segments with their points in apposition, which means that we have four possible points of sloughing. With the septotome but a single flap is cut, and that having what many rhinologists consider the ideal shape of the flap for this
Predictors of Adverse Outcome and Transient Neurological Dysfuntion Following Surgical Treatment of Acute Type A Dissections
Authors: Marek P. Ehrlich, Martin Schillinger, Martin Grabenwöger, Alfred Kocher, Edda M. Tschernko, Paul Simon, Arthur Bohdjalian, Ernst Wolner
Journal: Circulation (2003)

Predictors of adverse outcome after replacement of the ascending aorta with resection of the intimal tear and open distal anastomosis were analyzed in 167 patients (109 male, median age 56). Median hypothermic circulatory arrest (HCA) time was 30 minutes (range 12 to 113). Eighty-six patients (pts) had surgery within 24 hours and 81 within 72 hours of symptom onset. Thirty-seven pts had only ascending aortic replacement, 128 had hemiarch repair, and in 2 the entire arch was replaced. The aortic valve was replaced in 37 pts, resuspended in 116, and untouched in 14. Either death or permanent neurological dysfunction was considered an adverse outcome (AO). AO occurred in 30.5% (51/167) of patients overall. Multivariate analysis revealed that the only significant (P<0.05) independent preoperative predictor of AO was hemodynamic instability (OR 6.0). Transient neurological dysfunction (TND) occurred in 19 of 116 patients (16.4%). Significant predictors of TND were increasing age >60 (OR 3.4 and 7.0 in the second and third tertile as compared with the lowest tertile) and coronary heart disease (OR 3.4). Cumulative survival of patients (median follow-up 34 months) was 55% at 1, 49% at 5, and 44% at 8 years, indicating an excessive in-hospital mortality, but excellent long term outcome. Surgical treatment of acute type A dissections is still associated with a high incidence of adverse outcome, but results in excellent long-term survival. Earlier diagnosis, before the development of cardiac tamponade and hemodynamic compromise, is critical to improve the operative salvage rate.
Weight of the evidence on the human carcinogenicity of 2,4-D
Authors: M. A. Ibrahim, G. G. Bond, T. A. Burke, P. Cole, F. N. Dost, P. E. Enterline, M. Gough, R. S. Greenberg, W. E. Halperin, E. McConnell, I. C. Munro, J. A. Swenberg, S. H. Zahm, J. D. Graham
Journal: Environmental Health Perspectives (1991)

The phenoxy herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used to control the growth of weeds and broadleaf plants. We convened a panel of 13 scientists to weigh the evidence on the human carcinogenicity of 2,4-D. The panel based its findings on a review of the toxicological and epidemiological literature on 2,4-D and related phenoxy herbicides. The toxicological data do not provide a strong basis for predicting that 2,4-D is a human carcinogen. Although a cause–effect relationship is far from being established, the epidemiological evidence for an association between exposure to 2,4-D and non–Hodgkin's lymphoma is suggestive and requires further investigation. There is little evidence of an association between use of 2,4-D and soft-tissue sarcoma or Hodgkin's disease, and no evidence of an association between 2,4-D use and any other form of cancer. Scientists on the panel were asked to categorize 2,4-D as a “known,” “probable,” “possible,” or “unlikely” carcinogen or as a noncarcinogen in humans. The predominant opinion among the panel members was that the weight of the evidence indicates that it is possible that exposure to 2,4-D can cause cancer in humans, although not all of the panelists believed the possibility was equally likely: one thought the possibility was strong, leaning toward probable, and five thought the possibility was remote, leaning toward unlikely. Two panelists believed it unlikely that 2,4-D can cause cancer in humans.
Treatment of Hodgkin's lymphoma.
Authors: A. McMillan, R. Pearce, R. Chopra, A. H. Goldstone, D. C. Linch
Journal: BMJ (1992)

Smith and Taylor as the intravenous route mav be useful in certain circumstances.Until conclusivle advantages have been shown for the intravenous route in allergic emergencies, however, we recominend adherence to the guidelines in the British ANationial Forniularv and preferential use of the intramuscular route.2
Nocturnal blood pressure is elevated with natriuresis and proteinuria as renal function deteriorates in nephropathy
Authors: Michio Fukuda, Miwa Munemura, Takeshi Usami, Naoyuki Nakao, Oki Takeuchi, Yoshinobu Kamiya, Atsuhiro Yoshida, Genjiro Kimura
Journal: Kidney International (2004)
Indications for electric convulsion therapy and its use by senior psychiatrists.
Authors: D Gill, J Lambourn
Journal: BMJ (1979)

A survey by questionnaire of all senior psychiatrists in the Wessex Region showed that they considered depressive psychosis to be the major indication for electric convulsion therapy (ECT). A good clinical response was thought to be predicted by the presence of psychomotor retardation, depressive delusions, depressed mood, early morning wakening, diurnal variation, loss of appetite, and agitation. ECT was judged to be extremely useful for treating mania and acute undifferentiated, catatonic, and paranoid schizophrenia; of some use in hypochondriasis; but of little value or contraindicated when there was severe, depersonalisation, or hysterical symptoms. Only 40% of the psychiatrists favoured unilateral ECT, and the variation in electrode placements used by different psychiatrists was surprising. Eighty per cent of the respondents used courses averaging six to eight treatments given over two or three weeks. Results obtained in this study, based on clinical judgment, differed from research findings, which emphasises the need for further study of this important treatment.
803 EFFICACY, SAFETY AND IMPACT ON QUALITY OF LIFE OF SORAFENIB IN ELDERLY PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA. PRELIMINARY RESULTS OF A PHASE II STUDY
Authors: G. Mantovani, E. Massa, C. Spiga, L. Chessa, C. Madeddu, T. Zolfino, S. Lepori, G. Serra, M.R. Piras, S. Marini
Journal: Journal of Hepatology (2009)
Detection of polycyclic aromatic hydrocarbon-DNA adducts in human lung.
Authors: A Weston, E D Bowman, P G Shields, G E Trivers, M C Poirier, R M Santella, D K Manchester
Journal: Environmental Health Perspectives (1993)

Synchronous fluorescence spectroscopy has been combined with immunoaffinity chromatography (IAC) and HPLC to detect polycyclic aromatic hydrocarbon (PAH)-DNA adducts and measure r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE)-DNA adducts in human tissues and cells. A monoclonal antibody (8E11) that recognizes a range of PAH-DNA adducts, but not chemically unrelated adducts, was used to prepare IAC columns. Samples of DNA (25 from human lung and 8 positive and negative controls) were hydrolyzed enzymically and subjected to IAC. Adducts captured by the antibodies and eluted in NaOH (50 mM) were analyzed for fluorescent properties. The spectral fluorescence excitation-emission matrices suggested the presence of mixtures of PAH-DNA adducts in some of the eluates. The eluates were subsequently hydrolyzed with acid (HCl, 0.1 N, 3 hr) and reanalyzed by synchronous fluorescence spectroscopy using a wavelength differential of 34 nm. In 6 of the 25 human lung DNA samples, materials with HPLC retention times identical to benzo[a]pyrene-7,10/8,9-tetrahydrotetrol were found to have fluorescence characteristics indistinguishable from pyrene. Comparisons with appropriate standards indicated that BPDE-DNA adduct levels were between 1 and 40 adducts in 10(8) unmodified nucleotides. No correlation was observed between lung DNA-adduct levels and measures of recent smoking (serum cotinine), but tissue samples taken from different portions of the same lungs showed variation in the DNA adduct levels detected. This finding complicates interpretation of the data and has important implications for the design of future experiments.
New IOM Report Links Agent Orange Exposure to Risk of Birth Defect in Vietnam Vets' Children
Authors: Joan Stephenson
Journal: JAMA (1996)

NEW EVIDENCE reveals a tentative link between exposure to chemical defoliants that were used in the Vietnam War and an increased risk of spina bifida in veterans' children, according to a recently issued report by the National Academy of Sciences' Institute of Medicine (IOM). The congressionally mandated report,<i>Veterans and Agent Orange: Update 1996</i>, is the second in a series of biennial reassessments of the health effects of Agent Orange and other herbicides. In addition to noting limited or suggestive evidence of an increased risk of the birth defect in exposed veterans' children, it said that new studies confirm the 1994 report's finding that there is sufficient evidence that exposure to these chemicals is linked with soft tissue sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, and chloracne. The report also described "limited or suggestive" evidence, based on studies of occupational exposure to herbicides or dioxin outside of Vietnam, that exposure may be