tbuckley/cabot-search huggingface dataset:
Quantities of α<sup>Q</sup> chain variants in heterozygotes with and without a concomitant β‐thalassemia trait
Authors: W.‐B. Qin, E. Baysal, K. F. Wong, T. P. Molchanova, D. D. Pobedimskaya, S. Sharma, J. B. Wilson, T. H. J. Huisman
Journal: American Journal of Hematology (1994)

Abstract We have analyzed the quantities of α x chain‐containing hemoglobins (α x β 2 and α 2 x β 2 ,) in 14 heterozygotes for Hb Q‐India [α64(E13)Asp→His] or Hb Q‐Thalland [α74(EF3)Asp→Hls]; both amino acid replacements are the result of mutations in the α1‐globin gene. Five of these persons (three with Hb Q‐India and two with Hb Q‐Thailand) had an additional β°‐thalassemia heterozygoslty. The average quantities for Hb Q + Hb Q 2 in the four groups were 17.2% ( Q /αα; β A /β A ), 9.5% (αα Q /αα; β A /β° Th ), 26.8% (‐α Q /αα;β A /β A ), and 16.95% (‐α Q /αα; β A /β° Th ). These variations can best be explained by a posttranslational control mechanism; an imbalance in the α A , α Q , and β A chain ratio will favor the α z Q β z formation when an α‐thalassemia is present and will reduce its formation in the presence of a β‐thalassemia heterozygosity. © 1994 Wiley‐Liss, Inc.
Treating a Patient with the Werner Syndrome and Osteoporosis Using Recombinant Human Insulin-like Growth Factor
Authors: Craig D. Rubin
Journal: Annals of Internal Medicine (1994)

Objective: To assess the safety and effect of recombinant human insulin-like growth factor 1 (rhIGF-1) on measures of bone metabolism in a human model of age-related osteoporosis. Design: 6-month prospective case study. Setting: General clinical research center. Patients: 1 patient with the Werner syndrome, a low serum IGF-1 level, and osteoporosis. Intervention: Daily subcutaneous administration of rhIGF-1 for 6 months. Measurements: Serum alkaline phosphatase, osteocalcin, type I procollagen C-peptide and urinary hydroxyproline, calcium, and pyridinoline cross-links as measures of bone metabolism and radial shaft, femoral neck, and lumbar bone masses. Results: Serum osteocalcin and type I procollagen C-peptide increased during rhIGF-1 therapy (P < 0.05). Twenty-four hour urinary calcium, hydroxyproline, and pyridinoline cross-links were also higher after treatment than they were before treatment (P < 0.05). During 6 months of treatment, the bone mineral density of the L2 to L4 vertebrae increased 3%; this value exceeded the coefficient of variation of this measurement. Bone density at the femoral neck and radial shaft changed by less than the coefficient of variation of these measurements. No significant changes in serum glucose values or other adverse effects of treatment were noted. Conclusions: Treatment with rhIGF-1 increased both bone formation and resorption in a patient with the Werner syndrome, a low baseline serum IGF-1 level, and established osteoporosis. Because lumbar bone mass increased without evidence of bone loss in the appendicular skeleton, a net increase in bone formation (formation greater than resorption) may have been responsible.
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway.
Authors: J Z Weinberger, R N Germain, B Benacerraf, M E Dorf
Journal: The Journal of Experimental Medicine (1980)

4-Hydroxy-3-nitrophenyl (NP) derivatized syngeneic spleen cells injected intravenously stimulate maturation of an antigen-binding, idiotype-bearing induction-phase suppressor cell population, as well as an idiotype-binding anti-idiotype-bearing effector-phase suppressor cell population. Both cell types are present simultaneously in the spleen cell population 7-d after their induction. Furthermore, the cell population with antigen-binding properties can, in the presence of NP-derivatized syngeneic cells, induce a population of effector suppressor cells. The precursors of the effector suppressor population are not sensitive to concentrations of cyclophosphamide which prevented the generation of induction phase suppressor cells. These data provide direct evidence in support of the theory of network regulation of immune suppression. X
Remarks on the RESULTS OF LUMBAR SYMPATHECTOMY IN THROMBO-ANGIITIS OBLITERANS
Authors: E. D. Telford, J. S. B. Stopford
Journal: BMJ (1933)

We have, since April, 1931, performed upwards of fifty operations on the autonomic nervous system by cervicaldorsal ganglionectomy or excision -of the lumbar cords and ganglia.These operations have been done for a variety of conditions, chiefly thrombo-angiitis obliterans, Raynaud's disease, " acrocyanosis," anterior poliomyelitis, Hirschsprung's disease, and scleroderma.Of the patients treated we have, for the purpose of this communication, chosen the first sixteen cases of sympathectomy done for
Significance of increasing adhesion of cord blood hematopoietic cells and a new method: Platelet microparticles
Authors: Bin Liu, Can Liao, Jingsong Chen, Shaoling Gu, Shaoqin Wu, Zunpeng Xu
Journal: American Journal of Hematology (2003)

Hematopoietic recovery after transplantation with cord blood (CB) is slower than with bone marrow (BM) and mobilized peripheral blood. Adhesion molecules (AMs) on hematopoietic cells are involved in hematopoietic cells' homing. It may be possible to enhance CB CD34+ cells engraftment by increasing their expressions of AM. Twenty-three patients with childhood acute leukemia treated with unrelated CBT were studied. It was found that the time to neutrophil recovery correlated with CXCR4 and the time to platelet recovery correlated with both CD62L and CXCR4. Platelet microparticles (PMPs) carry some AMs such as aIIb b (CD41), P-selectin (CD62P), and CXCR4, CD34+ cells express platelet-binding antigens (CD162 and CD11b). It was found that AMs were increased dramatically on CD34+ cells surface in the presence of PMPs, and CD34+ cells covered with PMPs adhered better to human umbilical vein endothelial cells and fibronectin. These findings suggested that PMPs could increase adhesion of donor's cells to host BM in CBT.
Soldier Suicide Rates Continue to Rise
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methodology of monitored release of a new preparation: buprenorphine.
Authors: A W Harcus, A E Ward, D W Smith
Journal: BMJ (1979)

The analgesic agent Temgesic (buprenorphine) was made available under monitored release regulations for one year, which yielded data from 1736 doctors on 9123 patients. An analysis of 17 120 administrations of the drug confirmed the results of the pre-licensing clinical studies encompassing data from nine British hospitals on 483 patients. No important new adverse effects attributable to the product were observed, and apart from giving reassurance, the usefulness of monitored release is questioned in the light of the relatively small amount of additional information arising from it.
THE FIELD WHEREIN THE WORK OF THE SURGEON APPROACHES THAT OF THE PHYSICIAN.
Authors: CHARLES C. ALLISON
Journal: JAMA (1907)

Cases in which a reasonable doubt exists as to the propriety of an operation are met sufficiently often to warrant their consideration. <h3>THE SURGEON AND THE PHYSICIAN.</h3> The training, character of practice and experience of the general surgeon differ in a measure from those of the internist—their observations being made from a different point of view, but their conclusions, when based on all of the evidence, should agree. The experienced surgeon possesses an advantage from his opportunities to inspect and to palpate the living tissues and to study the pathology in its various degrees of severity and stages of progress and to compare such findings with the pre-operative symptoms. Repeatedly thus to study the symptoms before operation, and to check up the findings revealed by the exploration, contributes in the most practical way to the development of his judgment. The relatively greater experience of the internist in his study of
Utility of Lateral Imaging in Rectosigmoid Bleeding
Authors: GORDON D. GRAHAM, DOUGLAS van NOSTRAND, DOUGLAS EGGLI, JANET NEUTZE
Journal: Clinical Nuclear Medicine (1985)

Technetium labeled red blood cells are used for imaging gastrointestinal bleeding. Images are commonly obtained in the anterior projection. The authors have found rectosigmoid accumulation may be overlooked if a lateral image is not obtained. The authors routinely recommend a lateral image in the final image series.
WHO warns that multidrug resistant TB will spread
Authors: M. Ashurst
Journal: BMJ (1996)

Careless administration of routine treatment for tuberculosis in South Africa has produced the world's highest incidence of drug resistant forms of the disease, the World Health Organisation has warned. And this misuse of drugs could speed up the spread of tuberculosis resistant to multiple drugs to the rest of Africa and the developed world.

A survey of the tuberculosis epidemic in South Africa conducted during 10-21 June found that almost two thirds of clinics issuing drugs to treat tuberculosis did not monitor their …
Distinguishing between two types of musical emotions and reconsidering the role of appraisal
Authors: Agnes Moors, Peter Kuppens
Journal: Behavioral and Brain Sciences (2008)

Abstract The target article inventories mechanisms underlying musical emotions. We argue that the inventory misses important mechanisms and that its structure would benefit from the distinction between two types of musical emotions. We also argue that the authors' claim that appraisal does not play a crucial role in the causation of musical emotions rests on a narrow conception of appraisal.
Determination of cardiovascular velocities by dopplercardiometry: 2. Detection of impaired left ventricular function
Authors: D. Abelson, D. Bernbaum, J. F. Gunning, A. Mohiuddin
Journal: Cardiovascular Research (1971)

Thirteen patients with different forms of heart disease were studied by Doppler auscultation and dopplercardiometry, as well as cardiac catheterization and cine-angiography. Patients with haemodynamic evidence of impaired left ventricular function showed reduced pitch and amplitude of the early systolic (β1) Doppler signal.
Treatment of Progressive Ammonia Intoxication by Exclusion of the Colon
Authors: Stanley G. Dienst
Journal: New England Journal of Medicine (1964)

A FEW cases of surgically created portal–systemic shunts and progressive ammonia intoxication that have been improved by colectomy,1 hemicolectomy2 and colonic exclusion have been reported.3 The rationale for these procedures is to eliminate the ammonia produced by the high concentration of bacteria normally present in the colon.4 , 5 The case presented below re-emphasizes the role of the colon in the elevation of blood ammonia concentration and production of neurologic signs associated with portal–systemic shunts. The following is a chronologic outline of the major events in the course of this sixty-eight-year-old woman's illness: 1947, cholecystectomy; 1957, dilatation of commonduct stricture; 1961, choledochojejunostomy, . . .
Migratory Activity and Functional Changes of Green Fluorescent Effector Cells before and during Experimental Autoimmune Encephalomyelitis
Authors: Alexander Flügel, Tomasz Berkowicz, Thomas Ritter, Marta Labeur, Dieter E Jenne, Zhaoxia Li, Joachim W Ellwart, Michael Willem, Hans Lassmann, Hartmut Wekerle
Journal: Immunity (2001)
Managed Care
Authors: Paul M. Ellwood
Journal: JAMA (1996)

The modern<i>JAMA</i>has been working toward comprehensive American health system reform since 1987, emphasizing cost control, access for all, and promotion of quality.<sup>1</sup>One of us (P.M.E.) has been developing market-based health system thinking for more than 25 years.<sup>2</sup>The concept of managed care is hardly new. The Kaiser plans began in the American West in the 1930s.<sup>3</sup>The massive reform that has occurred in the 1990s has been phenomenal and largely unpredicted, although much of it has been called for by many authors.<sup>4-6</sup>Many patients, providers, and purchasers alike consider the system to be in turmoil, some even in chaos. But movement is profound and irreversible, at least in the short run. As we go forward, we believe that physicians should be more involved and influential in determining where the American health system is going. It is unrealistic to expect to return to unmanaged,
Persistent Impairment of Endothelial Vasomotor Function Has a Negative Impact on Outcome in Patients With Coronary Artery Disease
Authors: Yoshinobu Kitta, Jyun-ei Obata, Takamitsu Nakamura, Mitsumasa Hirano, Yasushi Kodama, Daisuke Fujioka, Yukio Saito, Ken-ichi Kawabata, Keita Sano, Tsuyoshi Kobayashi, Toshiaki Yano, Kazuto Nakamura, Kiyotaka Kugiyama
Journal: Journal of the American College of Cardiology (2009)
Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold
Authors: Ryotaro Hashizume, Kazuro L. Fujimoto, Yi Hong, Nicholas J. Amoroso, Kimimasa Tobita, Toshio Miki, Bradley B. Keller, Michael S. Sacks, William R. Wagner
Journal: Biomaterials (2010)
IMPROVEMENT IN EGFR WITH ATORVASTATIN MAY CONTRIBUTE TO REDUCTIONS IN HOSPITALIZATIONS FOR CONGESTIVE HEART FAILURE: TREATING TO NEW TARGETS (TNT) STUDY
Authors: Allison Kean, David D. Waters, Prakash C. Deedwania, Andrei Breazna, David A. DeMicco, Daniel J. Wilson
Journal: Journal of the American College of Cardiology (2011)
The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation.
Authors: A Wettergren, M Wojdemann, S Meisner, F Stadil, J J Holst
Journal: Gut (1997)

Glucagon-like peptide-1 (GLP-1)(7-36) amide is an intestinal incretin hormone which also inhibits gastric acid secretion in humans. Its mechanism of action is unclear, but it strongly inhibits vagally induced secretion (sham feeding), suggesting that it could influence vagal activity.The effect of intravenous GLP-1 (7-36 amide) (1 pmol/kg/min) was studied on pentagastrin induced acid secretion in otherwise healthy subjects, previously vagotomised for duodenal ulcer (n = 8) and in a group of young (n = 8) and old (n = 6) healthy volunteers.Pentagastrin increased acid secretion significantly in all three groups, but the plateau concentration in the vagotomised subjects was lower than in controls. Infusion of GLP-1 (7-36 amide) significantly inhibited acid secretion in the control groups (to 67 (SEM 6) and 74 (SEM 3)% of plateau concentrations in young and old controls, respectively) but had no effect in the vagotomised subjects. Differences in plasma concentrations of GLP-1 (7-36 amide), recovery of gastric marker, duodenal regurgitation, or Helicobacter pylori status could not explain the lack of effect. Blood glucose was lowered equally by GLP-1 (7-36 amide) in all subjects.The inhibitory effect of GLP-1 (7-36 amide) on acid secretion depends on intact vagal innervation of the stomach.
Bacterial Flora and Bacterial Counts of Infants' Bottle Feeds
Authors: J. Wright
Journal: BMJ (1951)

Where myxoedema exists, its treatment would be expected to inhibit the progress of atherosclerosis; but desiccated thyroid must be administered very cautiously in the presence of coronary disease (Bartels and Bell, 1939).Conversely, the induction of hypothyroidism for the relief of angina pectoris would seem to be an unwise procedure because of probable acceleration of the underlying atherosclerotic process.There is strong evidence from clinical, pathological, and experimental studies that an eminently desirable measure in the prevention of atherosclerosis is the pre- vention or correction of obesity.The virtues of a low- fat diet in this connexion are well known.A diet par- ticularly low in animal fat has what may prove to be an additional virtue-a low-cholesterol content.I am greatly indebted to Professor C. H. Best for helpful advice and criticism.
Clinicopathological Features of Homologous Recombination–Deficient Epithelial Ovarian Cancers: Sensitivity to PARP Inhibitors, Platinum, and Survival
Authors: Asima Mukhopadhyay, Elizabeth R. Plummer, Ahmed Elattar, San Soohoo, Bisha Uzir, Jennifer E. Quinn, W. Glenn McCluggage, Perry Maxwell, Harriet Aneke, Nicola J. Curtin, Richard J. Edmondson
Journal: Cancer Research (2012)

Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination-deficient (HRD) status on the clinicopathologic features, chemotherapy response, and survival outcomes of patients with EOCs. HR status was determined in primary cultures from ascitic fluid in 50 chemotherapy-naïve patients by a functional RAD51 immunofluorescence assay and correlated with in vitro sensitivity to the PARP inhibitor (PARPi), rucaparib. All patients went on to receive platinum-based chemotherapy; platinum sensitivity, tumor progression, and overall survival were compared prospectively in HR-competent versus HRD patients. Compared with HR-competent patients, the HRD group was predominantly serous with a higher median CA125 at presentation. HRD was associated with higher ex vivo PARPi sensitivity and clinical platinum sensitivity. Median follow-up duration was 14 months; patients in the HRD group had lower tumor progression rates at 6 months, lower overall/disease-specific death rates at 12 months, and higher median survival. We therefore suggest that HRD as predicted by a functional RAD51 assay correlates with in vitro PARPi sensitivity, clinical platinum sensitivity, and improved survival outcome.
High lead exposure and auditory sensory-neural function in Andean children.
Authors: S A Counter, M Vahter, G Laurell, L H Buchanan, F Ortega, S Skerfving
Journal: Environmental Health Perspectives (1997)

We investigated blood lead (B-Pb) and mercury (B-Hg) levels and auditory sensory-neural function in 62 Andean school children living in a Pb-contaminated area of Ecuador and 14 children in a neighboring gold mining area with no known Pb exposure. The median B-Pb level for 62 children in the Pb-exposed group was 52.6 micrograms/dl (range 9.9-110.0 micrograms/dl) compared with 6.4 micrograms/dl (range 3.9-12.0 micrograms/dl) for the children in the non-Pb exposed group; the differences were statistically significant (p < 0.001). Auditory thresholds for the Pb-exposed group were normal at the pure tone frequencies of 0.25-8 kHz over the entire range of B-Pb levels, Auditory brain stem response tests in seven children with high B-Pb levels showed normal absolute peak and interpeak latencies. The median B-Hg levels were 0.16 micrograms/dl (range 0.04-0.58 micrograms/dl) for children in the Pb-exposed group and 0.22 micrograms/dl (range 0.1-0.44 micrograms/dl) for children in the non-Pb exposed gold mining area, and showed no significant relationship to auditory function.
Autoimmunization with Irradiated Tumour Cells in Human Malignant Melanoma
Authors: R. L. Ikonopisov, M. G. Lewis, I. D. Hunter-Craig, D. C. Bodenham, T. M. Phillips, C. I. Cooling, J. Proctor, G. H. Fairley, P. Alexander
Journal: BMJ (1970)

Thirteen patients have been immunized with their own irradiated melanoma cells on one or more occasions. Following these autografts tumour-specific cytotoxic antibodies were produced, the longest response lasting 14 days. This procedure had no apparent effect on the course of the disease in these patients.
Diagnostic Thoracoscopy in Pleuro-pulmonary Infiltrates without Pleural Effusion
Authors: P. Faurschou
Journal: Endoscopy (1985)

In seven patients with pleuro-pulmonary infiltrates without pleural effusion, an artificial pneumothorax was induced, followed by diagnostic thoracoscopy, as the first and only invasive investigation; in all cases the diagnosis was confirmed by this simple procedure. The method has a low mortality correlated to other alternative diagnostic methods.
Early Anaphylaxis to Bee Sting
Authors: George A. Dean
Journal: JAMA (1963)

ANAPHYLAXIS to bee sting is a rarity in older medical literature. The earliest case known is that mentioned by Mease,<sup>1</sup>in 1836, when he recalled a letter from Dr. John R. Warren of Wardsboro, Vt., four years before. The actual stinging and its consequent fatality occurred on June 17, 1811, during Dr. Warren's childhood. Gould and Pyle,<sup>2</sup>in 1897, summarized several early cases, including the Vermont report of 1811 and other cases. Thompson, in 1869,<sup>3</sup>reported three fatalities from bee stings in England. The "WPA Guide to New York State," under Manchester, mentions the grave of Timothy Ryan who was said to have been stung to death by a bee, and, in 1956, Ripley noted the gravestone of Timothy Ryan in his column, "Believe It or Not." With this limited information, a stone-by-stone search was made of the old cemeteries in or near Manchester, N.Y., about 25
IDSA: Avoid Antibiotics for Most Throat Infections
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal