tbuckley/cabot-search huggingface dataset:
Controlled multicentre therapeutic trial of an unrefined carbohydrate, fibre rich diet in Crohn's disease.
Authors: J K Ritchie, J Wadsworth, J E Lennard-Jones, E Rogers
Journal: BMJ (1987)

Between 1 September 1980 and 31 August 1983, 352 patients with inactive or mildly active Crohn9s disease but not taking drug treatment apart from sulphasalazine were entered from 40 hospitals into a prospective trial to assess the effects of two different diets on disease activity over two years. One hundred and sixty two patients were randomly allocated to take a diet unrestricted in sugar and low in fibre and 190 to a diet with little or no sugar and high in unrefined carbohydrate. No clear difference in clinical course was detected among patients who accepted the two different types of dietary advice.
Twenty Years of Community Medicine
Authors: Lester S. King
Journal: JAMA (1975)

In the late 1940s, Hunterdon County in rural New Jersey had a population of about 40,000 and some 20 general practitioners but no hospital. Community leaders undertook a striking experiment that involved building a hospital and providing total medical care for the community. The guiding principles deserve specific mention: the family physician was essential; specialists would serve the hospital on a full-time basis; the hospital would have medical school affiliations and an active teaching program; and it would provide a broad spectrum of health services. There were no precedents for this program. A group of dedicated leaders surmounted vast difficulties, raised funds, and opened the hospital in 1953. In 1973 a symposium celebrated its 20th birthday. The ten speakers included several physicians closely connected with the program, together with others concerned with education, community health, and health affairs. The reports are informative and stimulating. They point to the extraordinary progress:
Lipoprotein changes in children after liver transplantation: Mild hypertriglyceridemia and a decrease in HDL/HDL ratio
Authors: Esther Granot
Journal: Hepatology (1998)

Hyperlipidemia is frequently observed in patients who undergo renal, cardiac, bone marrow, or liver transplantation, and its contribution to the long-term morbidity and survival of patients with organ transplants may be substantial. In the few studies that have focused on the pediatric age group, findings have been inconsistent. The lipoprotein profile of 10 children after liver transplantation was characterized and compared with those in normal population controls and 10 healthy siblings. Plasma triglyceride and cholesterol concentrations were determined, lipoprotein fractions (very-low-density lipoprotein [VLDL], low-density lipoprotein [LDL], and high-density lipoproteins [HDL2 and HDL3]) were isolated, their chemical compositions were analyzed (protein, phospholipids, triglycerides, free cholesterol, and cholesteryl ester), and the percent relative weight composition of the particles was calculated. Plasma triglyceride and VLDL cholesterol levels were higher post-liver transplantation (P < .05): triglycerides (mean +/- SD), 115.1 +/- 58.7 mg% versus 76.6 +/- 20.9 mg% in siblings and 60.0 +/- 25.0 mg% in normal population controls; very-low-density lipoprotein cholesterol (VLDL-C), 23.0 +/- 11.7 mg% versus 15.3 +/- 4.7 mg% and 13.0 +/- 8.0 mg%, respectively. Plasma triglyceride levels did not correlate with the length of the period after liver transplantation. Levels of LDL-C and total HDL-C and the relative weight composition of VLDL, LDL, HDL2, and HDL3 particles did not differ between post-liver transplantation children and controls. Posttransplantation, levels of HDL3, the normally predominant HDL subfraction, were decreased relative to HDL2 levels (HDL3, 1.3; HDL2, 2.3). Because this observed relative increase in larger cholesteryl ester-rich HDL particles (HDL2) may result from inhibition of cholesteryl ester-triglyceride transfer processes, cholesteryl ester transfer protein activity was assayed. Cholesteryl ester transfer protein activity did not differ between patients and controls. Thus, the lipoprotein changes observed in children post-liver transplantation are mild hypertriglyceridemia and a significant increase in HDL2 relative to HDL3. Because HDL2 is regarded as protective against atherosclerosis, this may be of clinical relevance.
Vismodegib for Locally Advanced Basal Cell Carcinoma in a Heart Transplant Patient
Authors: Carrie Ann Cusack, Rohit Nijhawan, Brett Miller, Mira Henien, Gregory Malat, Alden Doyle, Mark Abdelmalek
Journal: JAMA Dermatology (2014)

Immunosuppressed patients with solid organ transplants have an increased risk for nonmelanoma skin cancer. Vismodegib has been reported to be effective for select locally advanced or metastatic basal cell carcinomas. However, there is no data documenting the use and safety of vismodegib in immunosuppressed organ transplant patients.We describe a 78-year-old white man with a history of orthotopic heart transplant, immunosuppressed with low-dose cyclosporine, who presented to a specialty dermatology transplant clinic with multiple, recurrent, locally aggressive facial basal cell carcinomas. Through a multidisciplinary approach, the patient was started on vismodegib therapy. The pharmacokinetics of cyclosporine in the setting of vismodegib administration and weekly monitoring of cyclosporine levels ensured that therapeutic immunosuppression levels were achieved without toxic effects.To our knowledge, this is the first report that details vismodegib use in an immunosuppressed heart transplant patient receiving cyclosporine therapy. With a growing immunosuppressed organ transplant population at high risk for basal cell carcinoma, therapeutic options for locally advanced or metastatic disease are limited. Vismodegib appears to be a safe option for patients receiving cyclosporine therapy with routine monitoring. Future research is needed to evaluate the safety profile of vismodegib with other immunosuppressive agents.
MELD accurately predicts mortality in patients with alcoholic hepatitis
Authors: Winston Dunn, Laith H. Jamil, Larry S. Brown, Russell H. Wiesner, W. Ray Kim, K. V. Narayanan Menon, Michael Malinchoc, Patrick S. Kamath, Vijay Shah
Journal: Hepatology (2005)

Assessing severity of disease in patients with alcoholic hepatitis (AH) is useful for predicting mortality, guiding treatment decisions, and stratifying patients for therapeutic trials. The traditional disease-specific prognostic model used for this purpose is the Maddrey discriminant function (DF). The model for end-stage liver disease (MELD) is a more recently developed scoring system that has been validated as an independent predictor of patient survival in candidates for liver transplantation. The aim of the present study was to examine the ability of MELD to predict mortality in patients with AH. A retrospective cohort study of 73 patients diagnosed with AH between 1995 and 2001 was performed at the Mayo Clinic in Rochester, Minnesota. MELD was the only independent predictor of mortality in patients with AH. MELD was comparable to DF in predicting 30-day mortality (c-statistic and 95% CI: 0.83 [0.71-0.96] and 0.74 [0.62-0.87] for MELD and DF, respectively, not significant) and 90-day mortality (c-statistic and 95% CI: 0.86 [0.77-0.96] and 0.83 [0.74-0.92] for MELD and DF, respectively, not significant). A MELD score of 21 had a sensitivity of 75% and a specificity of 75% in predicting 90-day mortality in AH. In conclusion, MELD is useful for predicting 30-day and 90-day mortality in patients with AH and maintains some practical and statistical advantages over DF in predicting mortality rate in these patients. MELD is a useful clinical tool for gauging mortality and guiding treatment decisions in patients with AH, particularly those complicated by ascites and/or encephalopathy.
Do specific pockets of HLA-C molecules predispose Jewish patients to psoriasis vulgaris?
Authors: Anat Roitberg-Tambur, Adam Friedmann, Eli E. Tzfoni, Shoshana Battat, Rivka Ben Hammo, Cilly Safirman, Katsushi Tokunaga, Akihiko Asahina, Chaim Brautbar
Journal: Journal of the American Academy of Dermatology (1994)
Pigmented fibroepithelioma of Pinkus
Authors: R.M. Strauss, S. Edwards, G.I. Stables
Journal: British Journal of Dermatology (2004)

Journal Article Pigmented fibroepithelioma of Pinkus Get access R.M. Strauss, R.M. Strauss Leeds Centre for Dermatology and *Department of Histopathology, Leeds General Infirmary, Leeds, U.K R.M.Strauss. E‐mail: roland@strauss.karoo.co.uk Search for other works by this author on: Oxford Academic Google Scholar S. Edwards, S. Edwards Leeds Centre for Dermatology and *Department of Histopathology, Leeds General Infirmary, Leeds, U.K Search for other works by this author on: Oxford Academic Google Scholar G.I. Stables G.I. Stables Leeds Centre for Dermatology and *Department of Histopathology, Leeds General Infirmary, Leeds, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 6, 1 June 2004, Pages 1208–1209, https://doi.org/10.1111/j.1365-2133.2004.06018.x Published: 01 June 2004 Article history Accepted: 13 November 2003 Published: 01 June 2004
Early Detection for Prostate Cancer?
Authors: Paul H. Lange
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Early Detection for Prostate Cancer? Get access Paul H. Lange Paul H. Lange Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 17, 4 September 1991, Pages 1199–1201, https://doi.org/10.1093/jnci/83.17.1199 Published: 04 September 1991
Hemodynamic Findings in 123 Patients with Acute Myocardial Infarction on Admission
Authors: BARRY W. RAMO, NELSON MYERS, ANDREW G. WALLACE, FRANK STARMER, DAVID O. CLARK, ROBERT E. WHALEN
Journal: Circulation (1970)

Hemodynamic and clinical evaluations of 123 patients with acute myocardial infarction were performed during the first hour of admission to the hospital. In the 123 patients, the right atrial pressure was less than 10 mm Hg in 49 patients, the right atrial oxygen saturation was less than 70% in 97 patients, the arteriovenous oxygen difference was greater than 5.0 vol% in 78 patients. The arterial Po 2 was less than 90 mm Hg in 101 of 107 patients who could be evaluated while breathing room air. The cardiac index was depressed below 3.0 L/min/m 2 in 65 of 98 patients. The hemodynamic findings generally correlated with the clinical status of the patient; however, within each clinical class of patients there was a wide spectrum of values for each measurement evaluated. There was also considerable overlap of the values found within each clinical classification. It is concluded that hemodynamic evaluation of patients with acute myocardial infarction presents a profile of the patient which is frequently different from the profile that clinical evaluation presents. An objective hemodynamic classification of patients with acute myocardial infarction may provide a more useful index for the evaluation of the patient's prognosis and for the assessment of preventative therapy.
Effects of Acute Insulin-Induced Hypoglycemia on Spatial Abilities in Adults With Type 1 Diabetes
Authors: Rohana J. Wright, Brian M. Frier, Ian J. Deary
Journal: Diabetes Care (2009)

OBJECTIVE To examine the effects of acute insulin-induced hypoglycemia on spatial cognitive abilities in adult humans with type 1 diabetes. RESEARCH DESIGN AND METHODS Sixteen adults with type 1 diabetes underwent two counterbalanced experimental sessions: euglycemia (blood glucose 4.5 mmol/l [81 mg/dl]) and hypoglycemia (2.5 mmol/l [45 mg/dl]). Arterialized blood glucose levels were maintained using a hyperinsulinemic glucose clamp technique. During each session, subjects underwent detailed assessment of spatial abilities from the Kit of Factor-Referenced Cognitive Tests and two tests of general cognitive function. RESULTS Spatial ability performance deteriorated significantly during hypoglycemia. Results for the Hidden Patterns, Card Rotations, Paper Folding, and Maze Tracing tests were all impaired significantly (P ≤ 0.001) during hypoglycemia, as were results for the Cube Comparisons Test (P = 0.03). The Map Memory Test was not significantly affected by hypoglycemia. CONCLUSIONS Hypoglycemia is a common side effect of insulin therapy in individuals with type 1 diabetes, and spatial abilities are of critical importance in day-to-day functioning. The deterioration in spatial abilities observed during modest experimental hypoglycemia provides novel information on the cerebral hazards of hypoglycemia that has potential relevance to everyday activities.
Cytocompatibility of Ti-6Al-4V and Ti-5Al-2.5Fe alloys according to three surface treatments, using human fibroblasts and osteoblasts
Authors: K. Bordji, J.Y. Jouzeau, D. Mainard, E. Payan, P. Netter, K.T. Rie, T. Stucky, M. Hage-Ali
Journal: Biomaterials (1996)
Coffee, Arrhythmias, and Common Sense
Authors: Thomas B. Graboys, Bernard Lown
Journal: New England Journal of Medicine (1983)

"Bathing, exercise, fear, anger and any other state of mind may often be apt to excite the pulse," noted Celsus in A.D. 178. With the passage of nearly two milleniums, additions have been made to the list of factors that may upset the heartbeat. Clinical impressions and popular anecdotes relate arrhythmia to the consumption of caffeine, alcohol, and tobacco. In this issue of the Journal, Dobmeyer and co-workers1 have further documented an aspect of caffeine's effect on cardiac excitability.The initial scientific stimulus for the examination of factors exogenous to the heart that perturbed its rhythm was the work . . .
THE USE OF SURFACE ANESTHESIA IN THE TREATMENT OF PAINFUL MOTION
Authors: Edward Hollander
Journal: JAMA (1941)

<h3>To the Editor:—</h3> InThe Journal, June 7, page 2582, Hans Kraus in his paper on "The Use of Surface Anesthesia in the Treatment of Painful Motion" states: "Empirically... cutaneous anesthesia... relieves the deep-seated pain in muscular spasm. I have no explanation to offer as to how this deep effect of surface anesthesia works. It seems to be a fact, but the underlying physiologic explanation represents an interesting field for exploration." As to the explanation of the effect of surface anesthesia on pain, I would call attention to my article "Dependence of Sensation of Pain on Cutaneous Impulses" (<i>Arch. Neurol. &amp; Psychiat.</i><b>40</b>:743 [Oct.] 1938) in which I concluded: "Anesthetization of localized areas of hyperalgesia and hyperesthesia in the skin relieves pain arising from deeper structures, whether visceral or skeletal.... Pain from skeletal or visceral tissues is referred to the skin and may be explained by a modification of
Phase II Evaluation of a Novel Capecitabine Schedule in Combination with Lapatinib for Patients with HER2-Positive Metastatic Breast Cancer Refractory to Trastuzumab.
Authors: D. Gajria, M. Theodoulou, K. Feigin, S. Patil, S. Geneus, P. Drullinsky, G. D'Andrea, D. Lake, L. Norton, C. Hudis, T. Traina
Journal: Cancer Research (2009)

Abstract BackgroundCapecitabine (C) administered for 14 days followed by a 7 day rest (14—7) in combination with lapatinib (L) improved TTP in patients with HER2(+) metastatic breast cancer (MBC) that progressed following trastuzumab (T). We applied mathematical methods to C dosing which predicted 7 days of treatment (Tx) followed by 7 days of rest (7—7) to be optimal. In animal models, C(7—7) was better tolerated than C(14—7) at higher doses and led to improved survival. A phase I study in patients (pts) with MBC concluded the MTD of C(7—7) is 2,000mg BID. To optimize the combination of C+L, we are testing C(7—7) + L.MethodsEligible pts have measurable, HER2(+) MBC with progression following trastuzumab. HER2(+)=3+ or FISH-amplified. Pts have normal LVEF by MUGA, ECOG performance status (PS) ≤2 and normal organ function. Prior therapy is limited to &amp;lt;3 chemotherapy (CRx) regimens for MBC; prior fluoropyrimidine is not permitted. Tx = C (2,000mg orally BID, 7—7) plus L (1,250mg orally daily). Cycle length=4 weeks (wks). Pts were evaluated for toxicity every 4 wks, for response every 12 wks and for LVEF by MUGA every 12 wks. Primary endpoint: Response Rate. Secondary endpoints: toxicity by NCI CTCv3, stable disease (SD)&amp;gt;6 months and PFS. Using a Simon optimal 2-stage design, with alpha 10% and power 90% to discriminate between RR 10% and 25%, 21 pts will be accrued to the 1st stage. If &amp;gt;2 patients respond, 29 additional pts will be enrolled. If &amp;gt;7/40 pts respond, then C(7—7) + L will be considered worthy of further study.ResultsAs of 5/28/09, 12 pts are enrolled; 6 are evaluable for response. Median (med) age 61 years (41-71), med ECOG PS 0 (0-2), ER/PR(+) 5, HER2(+) 12. Sites of MBC: Viscera 5, Brain 2. Med LVEF 64% (51-71%). Prior Tx: Adjuvant: CRx (7), hormone Tx (3), T (4); MBC: CRx (6), hormone Tx (4), T (8). After a med of 3 cycles (1-8), 6 pts are evaluable for response: CR 0, PR 1, SD&amp;gt;6mo 2, SD&amp;lt;6 mo 3. Five pts are too early for response assessment; 1 pt discontinued Tx during 1st cycle for palliative radiation without documented progression. There were no treatment-related grade 4/5 events or unexpected toxicity. Tx-related Grade (Gr) 2 or 3 toxicity in &amp;gt;10% of pts includes: hand-foot syndrome (Gr 3: 8%, Gr 2: 17%) and diarrhea (Gr 2: 17%). There were no declines in LVEF.ConclusionCapecitabine (7—7) plus lapatinib appears well-tolerated and demonstrates activity in pts with HER2(+) MBC that has progressed following trastuzumab based therapy. Additional efficacy and safety data is expected prior to this meeting. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5113.
The Grant Method in the Surgery of Epithelioma of the Lip-Reply
Authors: W. W. Grant
Journal: JAMA (1913)

<h3>To the Editor</h3> —In reply to Dr. Ryfkogel's note, kindly permit me to quote from my article as formerly published inThe Journal, as follows: "When half or more of the entire lip is removed, I am in the habit of perfecting and completing the operation by making an incision from each angle of the mouth backward and slightly downward half to one inch in length, down to the buccal mucous membrane, and then separating the latter from overlying tissues above, below and posteriorly to the extent of half an inch. The lip above and below is now beveled from the inner border in order to conform to natural conditions and also to make it easier to cover. The mucous membrane is now divided in the middle line and the flaps united to the skin by one continuous suture of chromicized
MAGNESIUM LOWERS THE INCIDENCE OF POSTOPERATIVE JUNCTIONAL ECTOPIC TACHYCARDIA IN CONGENITAL HEART SURGICAL PATIENTS: IS THERE A RELATIONSHIP TO SURGICAL PROCEDURE COMPLEXITY?
Authors: Dingchao He, Nathaniel Sznycer-Taub, Yao Cheng, Robert McCarter, Richard Jonas, Hanumanthaiah Sridhar, Jeffrey Moak
Journal: Journal of the American College of Cardiology (2014)
Phyllis May Sykes
Authors: M. Matthews
Journal: BMJ (2012)

Phyllis May Richards was born in Wakefield, the younger of two sisters. Both her parents were active participants in the life of the local church, but one died when she was still only a child and the other when she was 13, so she and her sister, Connie, were brought up by a housekeeper and her husband. They were financially supported by a benevolent uncle.

Phyllis was a clever and intelligent child who was good at all the subjects in the school curriculum, especially mathematics …
Loss of p63 Leads to Increased Cell Migration and Up-regulation of Genes Involved in Invasion and Metastasis
Authors: Christopher E. Barbieri, Luo Jia Tang, Kimberly A. Brown, Jennifer A. Pietenpol
Journal: Cancer Research (2006)

Abstract p63, a homologue of the tumor suppressor p53, is critical for the development and maintenance of squamous epithelia. p63 is specifically expressed in the basal layers of stratified epithelial tissues and is considered a specific marker for cells of this type. The role of p63 in tumorigenesis remains poorly defined. Numerous studies have highlighted the oncogenic potential of the predominant p63 isoform ΔNp63α; however, data suggest that other p63 proteins can act as tumor suppressors or alter the metastatic potential of tumors. ΔNp63α can act as a transcriptional repressor, but the link between the transcriptional functions of p63 and its biological role is still unclear. In this study, we used a loss-of-function approach to investigate the transcriptional programs controlled by p63. Disruption of p63 in squamous cell lines resulted in down-regulation of transcripts specifically expressed in squamous tissues and a significant alteration of keratinocyte differentiation. Interestingly, we found that disruption of p63 led to up-regulation of markers of nonepithelial tissues (mesenchyme and neural tissue) in both primary and immortalized squamous cells. Many of these up-regulated genes are associated with increased capacity for invasion and metastasis in tumors. Furthermore, loss of p63 expression was accompanied by a shift toward mesenchymal morphology and an increase in motility in primary keratinocytes and squamous cell lines. We conclude that loss of endogenous p63 expression results in up-regulation of genes associated with invasion and metastasis, and predisposes to a loss of epithelial and acquisition of mesenchymal characteristics. These findings have implications for the role of p63 in both development and tumorigenesis. (Cancer Res 2006; 66(15): 7589-97)
Randomised trial of antivenom in snake envenomation with prolonged clotting time.
Authors: P P Thomas, J Jacob
Journal: BMJ (1985)

Apres morsures par Naja naja, Bungarus caeruleus, Echis carinatus ou Vipera russelli, 26 malades recoivent la dose recommandee, 15 ampoules, de l'antivenin ; 27 recoivent une dose a peu pres moitie moindre. Les resultats ne montrent pas de difference significative entre les 2 groupes
Psychiatric morbidity in a general practice in an Indian city.
Authors: C Shamasundar, S K Murthy, O M Prakash, N Prabhakar, D K Krishna
Journal: BMJ (1986)

Psychiatric morbidity in an Indian general practice was studied using the 12 item version of the General Health Questionnaire to screen 882 patients who represented 9000 consecutive adult patients attending the practice. The questionnaire was valid with a cutting score of 1/2 when compared with section 1 of the standardised Indian Psychiatric Survey Schedule. The probable prevalence of psychiatric morbidity was 35.9%. The general practitioner identified only about 25% of patients. Five of the 12 questions on the General Health Questionnaire had a higher discriminatory capacity, and the performance of the patients on these five questions was valid when compared to section 1 of the Indian Psychiatric Survey Schedule.