tbuckley/cabot-search huggingface dataset:
Enhancing Patient-Provider Communication With the Electronic Self-Report Assessment for Cancer: A Randomized Trial
Authors: Donna L. Berry, Brent A. Blumenstein, Barbara Halpenny, Seth Wolpin, Jesse R. Fann, Mary Austin-Seymour, Nigel Bush, Bryant T. Karras, William B. Lober, Ruth McCorkle
Journal: Journal of Clinical Oncology (2011)

Purpose Although patient-reported cancer symptoms and quality-of-life issues (SQLIs) have been promoted as essential to a comprehensive assessment, efficient and efficacious methods have not been widely tested in clinical settings. The purpose of this trial was to determine the effect of the Electronic Self-Report Assessment–Cancer (ESRA-C) on the likelihood of SQLIs discussed between clinicians and patients with cancer in ambulatory clinic visits. Secondary objectives included comparison of visit duration between groups and usefulness of the ESRA-C as reported by clinicians. Patients and Methods This randomized controlled trial was conducted in 660 patients with various cancer diagnoses and stages at two institutions of a comprehensive cancer center. Patient-reported SQLIs were automatically displayed on a graphical summary and provided to the clinical team before an on-treatment visit (n = 327); in the control group, no summary was provided (n = 333). SQLIs were scored for level of severity or distress. One on-treatment clinic visit was audio recorded for each participant and then scored for discussion of each SQLI. We hypothesized that problematic SQLIs would be discussed more often when the intervention was delivered to the clinicians. Results The likelihood of SQLIs being discussed differed by randomized group and depended on whether an SQLI was first reported as problematic (P = .032). Clinic visits were similar with regard to duration between groups, and clinicians reported the summary as useful. Conclusion The ESRA-C is the first electronic self-report application to increase discussion of SQLIs in a US randomized clinical trial.
An International Study of Patient Compliance With Hemodialysis
Authors: Anthony J. Bleyer
Journal: JAMA (1999)

ContextInternational differences in compliance of patients undergoing hemodialysis are poorly characterized and could contribute to international survival differences.Objective To compare international differences in patient compliance with hemodialysis treatments.Design A prospective observational study of patients undergoing hemodialysis in 1995 and a cross-sectional survey of health care professionals caring for hemodialyzed patients in 1996. Setting and PatientsFour dialysis centers in the southeastern United States with 415 patients undergoing hemodialysis, 1 center in Sweden with 84 patients, and 4 centers in Japan with 194 patients participated in the prospective observational study.In the cross-sectional survey, nurses and nephrologists from the United States (n = 49), Japan (n = 21), and Sweden (n = 16) responded to questions regarding the compliance of their patients undergoing hemodialysis. Main Outcome MeasuresPercentage of patients who miss a dialysis treatment and number of missed dialysis treatments. ResultsOf 415 US patients, 147 missed 699 treatments over a 6-month period (28.1 missed treatments per 100 patient-months or 2.3% of all prescribed treatments).During a 3-month period, there were 0 missed treatments per 100 patient-months for patients from Japan and 0 missed treatments per 100 patient-months for patients from Sweden (PϽ.001).In the cross-sectional survey, the mean (SD) estimated percentage of patients missing a treatment per month was 4% (3%) for the United States, 0% for Japan, and 0.1% (3%) for Sweden (PϽ.001).Conclusions Noncompliance is much more common in US patients undergoing hemodialysis than Swedish and Japanese patients.The implications of these results for international differences in survival deserve further study.
Abstract 3305: Sustained production of a soluble IGF-I receptor by gutless adenovirus - transduced host cells protects from tumor growth in the liver .
Authors: Ni Wang, Yifan Lu, Amelie Pilotte, Maxime Pinard, Rénald Gilbert, Bernard Massie, Pnina Brodt
Journal: Cancer Research (2013)

Abstract The IGF-I receptor (IGF-IR) plays an important role in malignant disease by increasing cancer cell survival and promoting metastasis. It is presently the target of several drugs in clinical trials. Gene therapy is currently being developed for cancer treatment using different nanoparticle vectors designed to deliver therapeutic genes that could induce cell death, increase sensitivity to chemotherapy, block angiogenesis or enhance the anti-cancer immunological response. Previously, we have shown that the implantation of autologous bone-marrow stromal cells producing a soluble form of IGF-IR (sIGFIR) inhibited experimental liver metastasis of several tumor types in mice. Here we evaluated the utility of adenovirus-based gene delivery for generating therapeutically effective plasma levels of this decoy. A third generation gutless adenovirus was selected to deliver the sIGFIR gene because of its reduced immunogenicity and preferential tropism for the liver, the main source of endocrine IGF-1. We found that HEK-293 cells transduced by this, but not by control adenoviruses, secreted soluble receptor protein that blocked IGF-I-induced tumor cell migration, proliferation and survival in vitro. Following virus injection in vivo, viral DNA was detectable by PCR in several host organs, particularly the liver, and this resulted in the production of measurable sIGFIR plasma levels for up to 21 days post injection. In mice producing virus-encoded sIGFIR, experimental liver metastasis was inhibited, indicating that sIGFIR levels were therapeutically effective. The results show that adenovirus-based delivery of inhibitory soluble proteins can provide an effective strategy for blockade of cancer cell growth. Citation Format: Ni Wang, Yifan Lu, Amelie Pilotte, Maxime Pinard, Rénald Gilbert, Bernard Massie, Pnina Brodt. Sustained production of a soluble IGF-I receptor by gutless adenovirus - transduced host cells protects from tumor growth in the liver . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3305. doi:10.1158/1538-7445.AM2013-3305
Precordial Movements over the Right Ventricle in Children with Pulmonary Stenosis
Authors: ROLAND E. SCHMIDT, ERNEST CRAIGE
Journal: Circulation (1965)

Twenty-three children with pulmonary stenosis were studied by means of displacement tracings taken over the right ventricle. The transducer was selected to pick up vibrations in the ultra-low frequency or palpable range. The patients were studied by cardiac catheterization and angiocardiography. Criteria previously established for normal children were applied to the patients with pulmonary stenosis. These provide a measure of the duration and relative height of the out-ward movement associated with ventricular systole. Recordings of precordial movement over the right ventricle in all of five children with severe pulmonary stenosis were abnormal by these criteria. Patients with mild pulmonary stenosis were normal in six of seven cases. An intermediate group (right ventricular peak pressures 60 to 100 mm. Hg) had abnormal records in seven of 11 instances. The "a" wave resulting from atrial contraction was exaggerated in severe pulmonary stenosis and was larger than normal in many of the mild and moderate cases. Recordings of precordial movement in pulmonary stenosis, though nonspecific in morphology, are nevertheless useful as an index of severity of the lesion, in timing phases of the cardiac cycle, in following the progress of cases before and after surgical interference, and as a method of improving appreciation of palpable phenomena at the bedside.
Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
Authors: Jian-Bin Wang, Jon W. Erickson, Reina Fuji, Sekar Ramachandran, Ping Gao, Ramani Dinavahi, Kristin F. Wilson, Andre L.B. Ambrosio, Sandra M.G. Dias, Chi V. Dang, Richard A. Cerione
Journal: Cancer Cell (2010)
A NEW AND SIMPLE METHOD OF OBTAINING THE URINE SEPARATELY FROM THE TWO KIDNEYS IN EITHER SEX.
Authors: M. L. HARRIS
Journal: JAMA (1898)

Owing to the vital importance of the renal function the desirability of being able to determine the presence or absence of a kidney, as well as its functional capacity, has long been recognized by every surgeon who has been called upon to remove one of these organs for some incurable disease. It is a well-known fact that, owing to an error or arrest of development, an individual may be possessed of but a single kidney, or one of the kidneys may be so atrophied or misformed as to possess but little, if any, functional activity. It has more than once been found at the autopsy that the kidney removed by the surgeon was the only one possessed by the patient. While absence of a kidney is quite rare, being found in only one out of about thirty-three hundred cases (Morris) or 0.03 per cent., still where but a single kidney
Law and medicine. Use of bed rails
Authors: A. R. Holder
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeting efficiency of RGD-modified nanocarriers with different ligand intervals in response to integrin αvβ3 clustering
Authors: Zhaoming Guo, Bing He, Hongwei Jin, Haoran Zhang, Wenbing Dai, Liangren Zhang, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang
Journal: Biomaterials (2014)
Effect of chronic antigen and beta 2 agonist exposure on airway remodeling in guinea pigs.
Authors: Z L Wang, B A Walker, T D Weir, M C Yarema, C R Roberts, M Okazawa, P D Paré, T R Bai
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We recently reported that chronic exposure to fenoterol (FEN) in guinea pigs increases in vivo and in vitro airway responsiveness to a degree similar to that induced by chronic antigen (ovalbumin [OA]) exposure. We hypothesized that these changes were due to airway inflammation and airway remodeling. To trace newly recruited granulocytes as a marker of inflammation and to detect DNA replication in resident airway wall cells, the nucleotide 5'-bromo-2'-deoxyuridine (BrdU) was administered intermittently over the six-wk period of chronic FEN and/or OA exposure. Noncartilaginous airway dimensions were measured and the area fraction of BrdU-immunoreactive and total nuclei in adventitia, smooth muscle, and epithelium was determined by immunohistochemistry and point counting. The proliferation index was defined as the ratio of the two area fractions in each wall area. The adventitial areas of FEN- and OA-treated airways were respectively 62 and 88% greater than those of control airways (p < 0.05). The inner wall areas were not increased. The smooth muscle cell and epithelial cell proliferation index was increased after OA (smooth muscle index: control, 2.7 +/- 1.1% [SEM]; OA, 23.0 +/- 3.7%; p < 0.02) but not after FEN exposure, and there was an increased number of BrdU-immunoreactive granulocytes in the adventitia and epithelium after OA but not after FEN exposure. The increased in vivo airways responsiveness produced by chronic OA or FEN exposure may be attributable to adventitial thickening and increased in vitro muscle contractility, but the cellular mechanisms underlying these and other airway wall responses are different.(ABSTRACT TRUNCATED AT 250 WORDS)
Progress in Medical Genetics
Authors: A. Donald Merritt
Journal: JAMA (1966)

When a new progress series appears in the medical and scientific literature, there is always concern that, if a need exists, it may not be met by the proposed annual volume. The issuance of the fourth annualProgress in Medical Geneticssignifies that the series has been well received and has found a useful niche in the midst of our information explosion.  One is always curious as to who will be chosen to write a scholarly topical review. In some areas there are numerous choices; in others the choice narrows to one person or group of persons working together. The selection here has been unusually good, both in the past and in the present volume. The eight articles in the present volume combine accurate information with readability. The subjects are Disorders of the Thymus and Other Lymphoid Tissues, R. D. A. Peterson, M. D. Cooper, and R. A. Good; Genetics
Bioethicists do participate in everyday practice
Authors: K. W. Anstey, L. Wright
Journal: BMJ (2012)

<b>Background:</b> The cytokines tumour necrosis factor (TNF)α and interleukin (IL)10 have been implicated in the pathogenesis of Crohn’s disease (CD), with increased concentrations reported in patients with active disease. However, limited data exist on their effects on disease phenotype in the same population. Certain single nucleotide polymorphisms (SNPs) within the promoter region of the IL10 (-1082G/A, -592C/A) and TNFα (-308G/A, -857C/T) genes have been associated with altered levels of circulating IL10 and TNFα. <b>Methods:</b> We conducted an Australian based case–control study (304 CD patients; 231 healthy controls) of these four SNPs. Further investigation of two SNPs was conducted using a logistic regression analysis. <b>Results:</b> We identified a possible association of both IL10 SNPs and TNFα-857 with CD. Further investigation of a relationship with disease severity showed a significant association of higher producing IL10-1082G and TNFα-857C alleles with stricturing behaviour, which was strongest when these alleles were combined and persisted after multivariate analysis (p = 0.007; odds ratio (OR) 2.37, 95% CI 1.26 to 4.43). In addition, the TNFα-857CC genotype was independently associated with familial CD (p = 0.03; OR 3.12; 95% CI 1.15 to 8.46). <b>Conclusion:</b> These two SNPs may help to predict disease behaviour in CD patients, which may be clinically useful in shaping treatment of the disease at an earlier stage.
Germline genomic variants associated with childhood acute lymphoblastic leukemia
Authors: Lisa R Treviño, Wenjian Yang, Deborah French, Stephen P Hunger, William L Carroll, Meenakshi Devidas, Cheryl Willman, Geoffrey Neale, James Downing, Susana C Raimondi, Ching-Hon Pui, William E Evans, Mary V Relling
Journal: Nature Genetics (2009)
Library Practice in Hospitals: A Basic Guide
Authors: Susan Crawford
Journal: JAMA (1973)

Of the approximately 3,000 health sciences libraries in the United States, some 60% are in hospitals whose holdings average 3,730 bound volumes and 115 current serials. Only 25% of all hospital libraries had one or more full-time personnel and less than 22% had a professional librarian. Thus, there is a predominance of nonprofessional persons in hospital libraries and heavy reliance upon untrained, voluntary assistants. <i>Library Practice in Hospitals</i>is a practical, pragmatic volume addressed to the day-to-day problems of a person who works in a community hospital library. The book is divided into three parts. "The Hospital and the Health Sciences Library" provides an overview of the library in the hospital—its role, relationship to the general staff, and the communication media it must handle. "Library Tools and Techniques" outlines the basic principles of selection, acquisition, processing, and use of books and journals. Fink and Stearns introduce the concept of a
Sodium Cyanate Induced Polyneuropathy in Patients with Sickle-Cell Disease
Authors: CHARLES M. PETERSON
Journal: Annals of Internal Medicine (1974)

Two patients with sickle-cell disease who were receiving sodium cyanate for 440 and 600 days, respectively, in doses of up to 44 and 41 mg/kg body weight · day, respectively, had polyneuropathy confirmed by physical examination, quantitative sensory evaluation, nerve conduction test, electromyography (EMG), and sural nerve biopsy. The polyneuropathy clinically improved with no specific treatment after cessation of cyanate administration. Nerve conduction studies were done in 27 patients and needle EMG on 2 patients maintained on sodium cyanate for various periods. Mean duration of treatment of 16 patients with nerve conduction abnormalities was 478 days as opposed to a mean of 278 days for 11 patients without conduction abnormalities. Mean maximum dose of cyanate for the group with conduction abnormalities was 38 mg/kg body weight · day as opposed to 33 mg/kg body weight · day for those without. Patients with nerve conduction abnormalities achieved a higher carbamylation of their hemoglobin than those without and showed a mean weight loss of 9% as opposed to minimal weight change in patients without conduction abnormalities.
THE LOCAL BLOOD FLOW IN HUMAN BONE MARROW IN LEUKEMIA AND NEOPLASTIC DISEASES AS DETERMINED BY THE CLEARANCE RATE OF RADIOIODIDE (I131) 1
Authors: N. L. Petrakis, S. P. Masouredis, Patricia Miller, Fauno L. Cordes
Journal: Journal of Clinical Investigation (1953)

Although considerable information has been obtained on the rate of blood flow in many or- gans (1), few data have been reported on the blood flow in human or animal bone marrow (2).The neglect of this aspect of marrow physiology is probably due to the technical difficulties en- countered in gaining access to the blood vessels of this diffuse organ in the intact animal or man.The extensive application of the radioisotope clearance technique described by Kety (3, 4) for the estimation of the regional circulation in muscle, liver, subcutaneous tissues, brain tissue, and skin (4-10) suggested its use as a clinically applicable method for the evaluation of the effec- tive local blood flow in the human bone marrow.This method is based on the premise that if a diffusible tracer substance is introduced into a tissue its clearance or removal is a function of all possible factors contributing to the local blood flow at the site of injection.In the present study, the relative rates of clear- ance of II8' from the bone marrow were determined in patients with various malignant dis- eases and leukemia.The radioiodide was in- jected into the bone marrow through a standard bone marrow needle, and the rate of disappear- ance of the isotope was measured with a Geiger-Mueller counter.In addition, simultaneous de- terminations of I'll clearance rates from the gas- trocnemius muscle were obtained for comparing the clearance rates obtained in the bone marrow 1 Presented in part at the Annual Meeting of Western Section of the American Federation for Clinical Re- search, Carmel, California, January 24, 1952.2Postgraduate Research Fellow, National Cancer In- stitute.with those found in an anatomically and physiologically different vascular bed.
The <b> <i>Rgr</i> </b> Oncogene Induces Tumorigenesis in Transgenic Mice
Authors: María Jiménez, Ignacio Pérez de Castro, Marta Benet, Juan F. García, Giorgio Inghirami, Angel Pellicer
Journal: Cancer Research (2004)

Abstract To study the oncogenic potential of Rgr in vivo, we have generated several transgenic Rgr mouse lines, which express the oncogene under the control of different promoters. These studies revealed that Rgr expression leads to the generation of various pathological alterations, including fibrosarcomas, when its transgenic expression is restricted to nonlymphoid tissues. Moreover, the overall incidence and latency of fibrosarcomas were substantially increased and shortened, respectively, in a p15INK4b-defective background. More importantly, we also have demonstrated that Rgr expression in thymocytes of transgenic mice induces severe alterations in the development of the thymocytes, which eventually lead to a high incidence of thymic lymphomas. This study demonstrates that oncogenic Rgr can induce expression of p15INK4b and, more importantly, that both Rgr and p15INK4b cooperate in the malignant phenotype in vivo. These findings provide new insights into the tumorigenic role of Rgr as a potent oncogene and show that p15INK4b can act as a tumor suppressor gene.
1021 HBSAG LEVELS DURING ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS B: PEGINTERFERON VERSUS ENTECAVIR
Authors: J.G.P. Reijnders, V. Rijckborst, M.J. Sonneveld, S.M.J. Scherbeijn, C.A.B. Boucher, B.E. Hansen, H.L.A. Janssen
Journal: Journal of Hepatology (2010)
Hydatidiform mole with coexistent viable fetus detected by routine AFP screening.
Authors: D H Smith, R H Picker, D M Saunders, M Sinosich, J G Grudzinskas
Journal: BMJ (1980)

Addiction to Distalgesic (dextropropoxyphene)Distalgesic is a proprietary preparation containing dextropropoxyphene 32-5 mg and paracetamol 325 mg per tablet.It is widely prescribed for mild to moderately severe pain.Both components are effective analgesics by mouth.Dextropropoxyphene was introduced in 1957 as a substitute for codeine.Five other proprietary preparations containing dextropropoxyphene are now available in the United Kingdom.Dextropropoxyphene is similar in structure to methadone.It is a centrally acting drug without antipyretic or anti-inflammatory on 29 July
Silicone breast prostheses and rheumatic symptoms: a retrospective follow up study.
Authors: E J Giltay, H J Bernelot Moens, A H Riley, R G Tan
Journal: Annals of the Rheumatic Diseases (1994)

OBJECTIVES--To determine whether women with silicone breast prostheses have more rheumatic complaints than controls. METHODS--The study included 287 women who had silicone breast prostheses implanted between 1978-90. For every patient a female control of the same age was selected who had had an aesthetic operation in the same year. A questionnaire was sent to this retrospective cohort of women with silicone breast prostheses and controls. RESULTS--Questionnaires were returned by 235 cases (82%) and 210 controls (73%). Patients reported more symptoms arising after surgery than controls (0.6 v 0.3 complaints per subject, p &lt; 0.001). The average interval between surgery and onset of complaints was 5.1 years for patients and 5.9 for controls. Complaints presented by patients were: painful joints (p &lt; 0.005), burning eyes (p &lt; 0.01), and skin abnormalities (p &lt; 0.005). Differences in the use of antirheumatic drugs or medical consultations related to rheumatic symptoms did not reach statistical significance. Further information obtained from the patients and controls reporting rheumatic symptoms did not reveal the presence of a specific syndrome in connection with silicone materials. CONCLUSION--Women with silicone breast prostheses report more rheumatic complaints after silicone implantation than controls, but there is no evidence of increased prevalence of common rheumatic diseases.