tbuckley/cabot-search huggingface dataset:
Synthesis and turnover of membrane glycoconjugates in monolayer culture of pig and human epidermal cells
Authors: HELEN W. DAVIES, M.D. TROTTER
Journal: British Journal of Dermatology (1981)

Journal Article Synthesis and turnover of membrane glycoconjugates in monolayer culture of pig and human epidermal cells Get access HELEN W. DAVIES, HELEN W. DAVIES MRC Unit on the Experimental Pathology of Skin, The Medical School, Birmingham B15 2TJ Search for other works by this author on: Oxford Academic Google Scholar M.D. TROTTER M.D. TROTTER MRC Unit on the Experimental Pathology of Skin, The Medical School, Birmingham B15 2TJ Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 6, 1 June 1981, Pages 649–658, https://doi.org/10.1111/j.1365-2133.1981.tb00751.x Published: 01 June 1981 Article history Accepted: 27 June 1980 Published: 01 June 1981
Hyperalimentation With Amino Acid and Casein Hydrolysate Solutions
Authors: James C. M. Chan
Journal: JAMA (1972)

Four premature infants aged 1 to 2 weeks and one 10-year-old child who developed metabolic acidosis (base excess [BE], —9 to —17 mEq/liter) with continuous intravenous amino acid alimentation for extended periods were studied before, during, and after the development of acidosis, to test the hypothesis that the acidosis is secondary to the excessive hydrogen ion (H+) intake from these casein hydrolysate and amino acid infusates. The net acid excretion (NAE) consisted of the sum of urinary titratable acid plus ammonium ion (NH<sub>4</sub><sup>+</sup>) minus bicarbonate radical (HCO<sub>3</sub><sup>-</sup>). The net acid input (NAI) consisted of the endogenous acid production plus the exogenous acid intake from the amino acid infusion. In all cases, metabolic acidosis developed whenever the NAI exceeded the NAE, and recovery occurred whenever the infusates were stopped or continued with a half-strength solution, allowing the NAE to exceed the NAI.
S17 Cardiovascular Risk Factors In People With Bronchiectasis: A Cross Sectional Study
Authors: V. Navaratnam, E. Millett, J. Hurst, S. Thomas, L. Smeeth, R. Hubbard, J. Brown, J. Quint
Journal: Thorax (2014)

<h3>Background</h3> We have previously demonstrated that individuals with bronchiectasis have a higher prevalence of cardiovascular disease compared to the general population.<sup>1</sup> It is unclear if this is due higher prevalence of cardiovascular risk factors amongst people with bronchiectasis or through other mechanisms. <h3>Methods</h3> We conducted a cross-sectional study using electronic primary care data from the Clinical Practice Research Database (CPRD-GOLD) to estimate the prevalence of cardiovascular risk factors (smoking habit, diabetes, hypertension, hyperlipidaemia, family history of cardiovascular disease) and medication commonly prescribed to manage cardiovascular disease amongst people with and without bronchiectasis. Logistic regression was used to generate odds ratios for each risk factor or cardiovascular drug, adjusting for age and sex. <h3>Results</h3> Approximately 3.9 million individuals were included in our study, 10,942 (0.3%) of which had a record of bronchiectasis. Individuals with bronchiectasis were predominantly female (60.4%) and the median age at time of diagnosis was 56.2 (Interquartile range: 40.6–67.5) years. The prevalence of hypertension, diabetes and hypercholesterolaemia was slightly lower in individuals with bronchiectasis. We also found that people with bronchiectasis were less likely to have prescriptions for beta blockers, angiotensin converting enzyme inhibitors or angiotensin II receptor blockers, anti-platelets and lipid lowering drugs (see Table 1). <h3>Conclusions</h3> Patients with bronchiectasis have a lower prevalence of cardiovascular risk factors compared to the general population. This raises the possibility that other factors associated with bronchiectasis could be contributing to the increase risk in cardiovascular disease. <h3>Reference</h3> Navaratnam V, Millett E, Hurst JR, Thomas S, Smeeth L, Hubbard R, Brown JS, Quint JK. The association between bronchiectasis and cardiovascular disease: A population based study. <i>American Journal of Respiratory and Critical Care Medicine</i> 2014; 189:A3618
Myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN, U): natural history and clinical outcome by treatment strategy
Authors: C D DiNardo, N Daver, N Jain, N Pemmaraju, C Bueso-Ramos, C C Yin, S Pierce, E Jabbour, J E Cortes, H M Kantarjian, G Garcia-Manero, S Verstovsek
Journal: Leukemia (2014)
Diabetes is associated with a higher risk of death than is prior myocardial infarction in the setting of coronary disease: results from the Duke cardiovascular database
Authors: Darren K. McGuire, Sunil V. Rao, Peter J. Joski, Gregory W. Barsness, Eric D. Peterson, James G. Jollis, Mark N. Feinglos, Christopher B. Granger
Journal: Journal of the American College of Cardiology (2002)
Worldwide Elimination of Hepatitis B Transmission: We Have the Way, We Need the Will
Authors: Donald P. Francis
Journal: JAMA (1989)

On a global basis, hepatitis B virus (HBV) infection is a leading cause of morbidity and mortality due to acute hepatitis and the sequelae of chronic HBV infection, namely, cirrhosis and primary hepatocellular carcinoma.<sup>1</sup>Although HBV-related diseases are most prevalent in Asia and Africa, no part of the world is spared. Even in areas with a relatively low incidence of infection, the impact is substantial. In the United States, it is estimated that 300 000 persons become infected with HBV annually and that the direct medical costs for acute and chronic hepatitis B—related diseases are more than $1 million per day.<sup>2</sup> The good news is that the tools necessary to eliminate the transmission of HBV and its related diseases are at hand. Hepatitis B vaccines, which were developed more than 10 years ago, have been shown to be safe and effective in preventing HBV infection in adults,<sup>3,4</sup>
Champions and betrayers of public health
Authors: K. Abbasi
Journal: BMJ (2003)

feelings of anger, frustration, and anxiety.Prisoners attributed drug misuse to social isolation.Prison staff said that fewer staff, more prisoners, high staff sickness rates, and prison staff management styles increased their stress levels.The authors state that health professionals, primary care trusts, policy makers, and prison management need to address prison environmental factors and the mental health of prison staff to have an impact on the mental health of prisoners.
Digital angiographic measurement of radiographic contrast material kinetics for estimation of myocardial perfusion.
Authors: J S Whiting, J K Drury, J M Pfaff, B L Chang, N L Eigler, S Meerbaum, E Corday, T Nivatpumin, J S Forrester, H J Swan
Journal: Circulation (1986)

We studied the use of digital angiography for the quantification of regional myocardial perfusion in the dog using selective left coronary arterial injection of radiographic contrast material as a flow dilution indicator. We developed algorithms for generating time-intensity curves from regions of interest over the proximal coronary artery and the myocardium and for densitometric error correction by subtraction of the intensity curve over a small lead blocker before logarithmic transformation. The resultant myocardial time-density curves were analyzed for time from injection to peak concentration (TPC) and for exponential washout rate (k). A linear correlation was found between absolute coronary arterial blood flow and both k (slope = 0.13, r = .85) and 1/TPC (slope = 0.18, r = .85). Reproducibility of TPC and k for repeated studies was 11% and 16%. Induced hyperemia significantly improved the sensitivity to stenosis by increasing the average difference in TPC and k between regions served by normal and stenotic coronary arteries to 65% and 80%, respectively. By combining selective coronary arterial injection with the left lateral x-ray projection it was possible to avoid most overlap of regional perfusion beds in the dog. This study suggests that contrast dilution measurements made during digital coronary angiography provide a means for assessing the hemodynamic significance of stenoses and the efficacy of therapeutic interventions.
Abstract 559: The molecular kinetics of p21 and Cdk4 dictates irreversible G0/G1 phase cell cycle arrest in CRPC cells.
Authors: Thippeswamy Gulappa, Rama S. Reddy, Suman Suman, Chendil Damodaran
Journal: Cancer Research (2013)

Abstract Deregulation of cell cycle progression is the hallmark of cancer; to this effect, several small molecules (AG-024322, AT7519, E7070, P1446A-05 and Flavopiridol) against cell cycle kinases are being developed to regulate cell cycle machinery that resulted in inhibition of tumor growth. The present study examined the effect of 3, 9-dihydroxy-2-prenylcoumestan-a furanocoumarin (Pso) on castration resistant prostate cancer cells (CRPC) cells. Treatment of CRPC (PC-3 and C4-2B) cells with Pso significantly caused irreversible G0-G1 cell cycle arrest that resulted in inhibition of cell proliferation. Protein analysis suggested that the expression of cdk inhibitors (CDKI) p21cip1 and p27kip1 were upregulated in both CRPC cell lines by Pso treatment. Studies using real-time reverse transcription-polymerase chain reaction analysis suggest that Pso transcriptionally regulates p21cip1 and p27kip1 in CRPC cells. Our immunofluorescence analysis pointed out that both p21cip1 and p27kip1 accumulated in the nucleus upon the treatment as compared to untreated CRPC cells. In addition, the cell cycle arrest was associated with decreased levels of both cyclins and cyclin-dependent kinases. However, cdk-4 appears to be more significantly downregulated when compared with either cyclins (D1, D2, D3 and Cyclin E) or other Cdk's (cdk2/6). Also, we noted an increased hypophosphorylated level of retinoblastoma (Rb) with a decreased in Rb phosphorylation resulted in inhibition of E2F1 function. Further, transient over expression of Cdk4 overcomes the Pso-induced G0-G1 arrest in CRPC cells. Also, knockdown of p21cip1 and p27kip1 expression with small interfering RNA significantly abrogated the Pso-induced G0-G1 cell cycle arrest suggested that induction of p21cip1 and p27kip1 is required for G0-G1 cell cycle arrest by Pso. Altogether our results strongly suggest that Pso could be a potential candidate for prevention and therapy against CRPC. Our ongoing studies using xenograft models of CRPC in nude mice may reveal the in vivo efficacy of Pso. Citation Format: Thippeswamy Gulappa, Rama S. Reddy, Suman Suman, Chendil Damodaran. The molecular kinetics of p21 and Cdk4 dictates irreversible G0/G1 phase cell cycle arrest in CRPC cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 559. doi:10.1158/1538-7445.AM2013-559
Sex Chromosomes, Crime, and Psychosis
Authors: GERALD R. CLARK, MARY A. TELFER, DAVID BAKER, MARVIN ROSEN
Journal: American Journal of Psychiatry (1970)

Questioning the belief that XYY men are predisposed to violent behavior, the authors compared XYY men in penal institutions with men with the Klinefelter syndrome (XXY). They found little difference between their behavior and criminal records. They conclude that XYY men have been stigmatized falsely and that their involvement in crimes and antisocial behavior may not be significantly different from the normal individual's.
Genetic susceptibility to total hip arthroplasty failure: a preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor
Authors: M H A Malik, F Jury, A Bayat, W E R Ollier, P R Kay
Journal: Annals of the Rheumatic Diseases (2007)

<b>Background:</b> Matrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). The individual responses to such stimuli may be dictated by genetic variation. <b>Objective:</b> To study the effect of single-nucleotide polymorphisms (SNPs) within these candidate genes. <b>Methods:</b> A case–control study of the MMP1, IL6 and VDR genes was performed for possible association with deep sepsis or aseptic loosening. All cases included in the study were Caucasian patients with osteoarthritis who had received a cemented Charnley total hip arthroplasty (THA) and polyethylene acetabular cup. Cases consisted of 91 patients with early aseptic loosening and 71 patients with microbiological evidence of deep infection on surgery. Controls consisted of 150 patients with THAs that were clinically asymptomatic for over 10 years and showed no radiographic features of aseptic loosening. DNA samples from all individuals were genotyped using Taqman allelic discrimination. <b>Results:</b> The C allele (p = 0.001; OR = 3.27; 95% CI 2.21 to 4.83) and C/C genotype (p = 0.001) for the MMP1 SNP were highly associated with aseptic failure when compared with controls. No statistically significant relationships were found between aseptic loosening and the MMP2, MMP4, IL6 –174 or VDRL SNPs. The T allele (p = 0.007; OR = 1.76; 95% CI 1.16 to 2.66) and T/T genotype (p = 0.028) for VDR-T were statistically associated with osteolysis owing to deep infection as compared with controls. No statistically significant relationship was found between septic failure and any of the other SNPs examined in this study. <b>Conclusions:</b> Aseptic loosening and possibly deep infection of THR may be due to the genetic influence of candidate susceptibility genes. SNP markers may serve as predictors of implant survival and aid in pharmacogenomic prevention of THR failure.
Physiologic Studies Following Surgical Correction of Atrial Septal Defect and Similar Lesions
Authors: KAI REHDER, JOHN W. KIRKLIN, RICHARD A. THEYE
Journal: Circulation (1962)

Physiologic observations were made on eight patients following repair of atrial septal defect or total anomalous pulmonary venous connection. A pattern of changes in cardiac output and atrial pressures during the first 3 postoperative days was noted. Cardiac output was abnormally low in some patients with obstructive pulmonary vascular disease or low atrial pressures. Transfusion of whole blood was effective in elevating cardiac output in the operating room and after operation. Left atrial pressure was higher than right atrial pressure in the operating room. Postoperatively left and right atrial pressures tended to become equal in some patients, and the levels were slightly elevated. Heart rate did not seem to be directly related to cardiac output. Ventilation was adequate with regard to elimination of carbon dioxide. Arterial oxygen saturation was maintained at 93 per cent or more by the use of oxygen-enriched mixtures. The difference in arteriovenous oxygen content was inversely related to cardiac output. Acidemia was present 2 to 4 hours after operation, but in general the pH of arterial blood had returned to normal by day 2. Some mechanisms possibly related to the observations are discussed.
Acute Hemorrhagic Cystitis in Children
Authors: Yoshio Numazaki, Shiro Shigeta, Tetsuro Kumasaka, Teiji Miyazawa, Masao Yamanaka, Namio Yano, Soji Takai, Nakao Ishida
Journal: New England Journal of Medicine (1968)

A viral etiology of acute hemorrhagic cystitis was sought in 11 children seven to 15 years of age. Type 11 adenovirus was recovered from the urine of nine of these, and a significant rise in neutralizing antibody titer against Type 11 adenovirus was demonstrated in all. No virus was isolated from the urine of normal children or children with other diseases. Type 11 adenovirus is proposed as an etiologic agent of acute hemorrhagic cystitis.
Diabetes, Muscles, and the Myth of Ulysses' Bow
Authors: Luigi Ferrucci, Stephanie Studenski
Journal: Diabetes Care (2009)

At the end of Homer's Odyssey , after 20 years of adventurous traveling, the goddess Athena brings Ulysses back to Ithaca disguised as an old man. With little hope for Ulysses' return, his faithful wife Penelope has reluctantly agreed to marry whoever wins a contest using Ulysses' bow. In spite of his infirmed appearance, Ulysses is the only contestant strong enough to string the bow and shoot an arrow through 12 axe-handles. Thus, the image of a hero as the “only one who can string the bow” has been embedded in civilization since before the beginning of written history and suggests that from time immemorial, people have equated strong muscles with youth and good health. Thousands of years later, we are beginning to understand exactly how health and age affect muscle, and we are now on the cusp of translating that knowledge into medical research and practice.

In this issue of Diabetes Care , Park et al. (1) from the Health, Aging, and Body Composition Study group report that in individuals aged 70–79 years, a diagnosis of diabetes is associated with accelerated decline in muscle mass, especially in women and in subjects with undiagnosed diabetes. These longitudinal findings open an important chapter in our understanding of the complications and consequences of diabetes and its effect on physical function. However, to fully understand the relevance of these findings, we should interpret them in the context of the known effects of age on body composition and of diabetes on muscle strength and physical function (2,3).

The aging process is associated with consistent changes in body composition in all animal species, from worms to rodents to primates, with few exceptions (4–6). With increasing age, lean …
The Eosinophilia-Myalgia Syndrome
Authors: Ronald J. Scheff
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 June 1990The Eosinophilia-Myalgia SyndromeRonald J. Scheff, MD, Arturo R. Rolla, MDRonald J. Scheff, MDSearch for more papers by this author, Arturo R. Rolla, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-12-964_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: A 57-year-old woman presented with a 1-week history of severe bilateral scalp pain that made her unable to comb her hair or place her head on a pillow. She also had a 3-week history of neck and bilateral shoulder and thigh myalgias, intermittent dry cough, dyspnea on exertion, fatigue, and low-grade fever.The initial diagnosis was temporal arteritis-polymyalgia rheumatica; however, her erythrocyte sedimentation rate was 32 mm/h. Her leukocyte count was 8800/mm3 with 44% eosinophils. She also had a mild increase in serum LDH and transaminases, with normal alkaline phosphatase and creatine kinase levels.The physical examination...Reference1. KilbourneSwygertPhilen ELR. Interim guidance on the eosinophilia-myalgia syndrome [Editorial]. Ann Intern Med. 1990;112:85-7. LinkGoogle Scholar1. VargaPeltonenUittoJimenez JJJS. Development of diffuse fasciitis with eosinophilia during L-tryptophan treatment: demonstration of elevated type I collagen gene expression in affected tissues. A clinicopathologic study of four patients. Ann Intern Med. 1990;112:344-51. LinkGoogle Scholar2. GoodmanFrerman SF. Organic acidemias due to defects in lysine oxidation 2-ketoadipic acidemia and glutaric acidemia. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease. 6th ed. New York: McGraw-Hill; 1989:845-53. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New England Deaconess Hospital Harvard Medical School Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical features of giant cell arteritisDrugs used in non-orthodox medicine 15 June 1990Volume 112, Issue 12Page: 964-964KeywordsCreatine kinaseDyspneaEosinophilsErythrocyte sedimentation rateFatigueFeversLactate dehydrogenaseMyalgiaPhosphatasesShoulders Issue Published: 15 June 1990 PDF downloadLoading ...
Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation
Authors: Katrin Friedbichler, Marc A. Kerenyi, Boris Kovacic, Geqiang Li, Andrea Hoelbl, Saliha Yahiaoui, Veronika Sexl, Ernst W. Müllner, Sabine Fajmann, Sabine Cerny-Reiterer, Peter Valent, Hartmut Beug, Fabrice Gouilleux, Kevin D. Bunting, Richard Moriggl
Journal: Blood (2010)
Safety and clinical efficacy of rapidly-generated trivirus-directed T cells as treatment for adenovirus, EBV, and CMV infections after allogeneic hematopoietic stem cell transplant
Authors: Ulrike Gerdemann, Usha L Katari, Anastasia Papadopoulou, Jacqueline M Keirnan, John A Craddock, Hao Liu, Caridad A Martinez, Alana Kennedy-Nasser, Kathryn S Leung, Stephen M Gottschalk, Robert A Krance, Malcolm K Brenner, Cliona M Rooney, Helen E Heslop, Ann M Leen
Journal: Molecular Therapy (2013)

Adoptive transfer of virus-specific T cells can prevent and treat serious infections with Epstein-Barr virus (EBV), cytomegalovirus (CMV), and adenovirus (Adv) after allogeneic hematopoietic stem cell transplant. It has, however, proved difficult to make this approach widely available since infectious virus and viral vectors are required for T cell activation, followed by an intensive and prolonged culture period extending over several months. We now show that T cells targeting a range of viral antigens derived from EBV, CMV, and Adv can be reproducibly generated in a single culture over a 2-3-week period, using methods that exclude all viral components and employ a much-simplified culture technology. When administered to recipients of haploidentical (n = 5), matched unrelated (n = 3), mismatched unrelated (n = 1) or matched related (n = 1) transplants with active CMV (n = 3), Adv (n = 1), EBV (n = 2), EBV+Adv (n = 2) or CMV+Adv (n = 2) infections, the cells produced complete virological responses in 80%, including all patients with dual infections. In each case, a decrease in viral load correlated with an increase in the frequency of T cells directed against the infecting virus(es); both immediate and delayed toxicities were absent. This approach should increase both the feasibility and applicability of T cell therapy. The trial was registered at www.clinicaltrials.gov as NCT01070797.