Association between Protein Levels and Mortality in Patients with Peripheral Arterial Disease
Authors: Tetsuji Fujita
Journal: Annals of Internal Medicine (2008)

Letters1 July 2008Association between Protein Levels and Mortality in Patients with Peripheral Arterial DiseaseTetsuji Fujita, MDTetsuji Fujita, MDFrom Jikei University School of Medicine, 105-8461 Tokyo, Japan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-1-200807010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the excellent article by Vidula and colleagues (1). The authors found that higher levels of d-dimer, C-reactive protein (CRP), and serum amyloid A were associated with higher all-cause and cardiovascular near-term mortality rates among 377 patients with peripheral arterial disease (PAD), 76 of whom died during 4 years of follow-up. Of particular interest is that elevation of CRP and serum amyloid A levels was a surrogate marker of death within 2 years after determination of these protein levels. The relative risk for death within 1 year after measurement of CRP and serum ...References1. Vidula H, Tian L, Liu K, Criqui MH, Ferrucci L, Pearce WH, et al. Biomarkers of inflammation and thrombosis as predictors of near-term mortality in patients with peripheral arterial disease: a cohort study. Ann Intern Med. 2008;148:85-93. [PMID: 18195333] LinkGoogle Scholar2. Chait A, Han CY, Oram JF, Heinecke JW. Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease? J Lipid Res. 2005;46:389-403. [PMID: 15722558] CrossrefMedlineGoogle Scholar3. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557-65. [PMID: 12432042] CrossrefMedlineGoogle Scholar4. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004;350:1387-97. [PMID: 15070788] CrossrefMedlineGoogle Scholar5. Kushner I, Rzewnicki D, Samols D. What does minor elevation of C-reactive protein signify? Am J Med. 2006;119:166.e17-28. [PMID: 16443421] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Tetsuji Fujita, MDAffiliations: From Jikei University School of Medicine, 105-8461 Tokyo, Japan.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBiomarkers of Inflammation and Thrombosis as Predictors of Near-Term Mortality in Patients with Peripheral Arterial Disease: A Cohort Study Himabindu Vidula , Lu Tian , Kiang Liu , Michael H. Criqui , Luigi Ferrucci , William H. Pearce , Philip Greenland , David Green , Jin Tan , Daniel B. Garside , Jack Guralnik , Paul M Ridker , Nader Rifai , and Mary M. McDermott Association between Protein Levels and Mortality in Patients with Peripheral Arterial Disease Mary M. McDermott , Lu Tian , and Kiang Liu Metrics 1 July 2008Volume 149, Issue 1Page: 64KeywordsC-reactive proteinsCardiovascular diseasesCholesterolHigh density lipoproteinMedical risk factorsPeripheral vascular diseaseProteinsRacial and ethnic issuesRegression analysisRelative risk ePublished: 1 July 2008 Issue Published: 1 July 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...