tbuckley/cabot-search huggingface dataset:
Abstract 4393: Optimizing DC vaccination by combination with oncolytic adenovirus coexpressing IL-12 and GM-CSF
Authors: Song-Nan Zhang, Il-Kyu Choi, Jing-Hua Huang, Ji-Young Yoo, Kyung-Ju Choi, Chae-Ok Yun
Journal: Cancer Research (2012)

Abstract Dendritic cell (DC)-based vaccination is a promising strategy for cancer immunotherapy. However, clinical trials have indicated that immunosuppressive microenvironments induced by tumors profoundly suppress antitumor immunity and inhibit vaccine efficacy, resulting in insufficient reduction of tumor burdens. To overcome these obstacles and enhance the efficiency of DC vaccination, we generated IL-12- and GM-CSF-coexpressing oncolytic adenovirus (Ad-αB7/IL12/GMCSF) as suitable therapeutic adjuvant to eliminate immune suppression and promote DC function. By treating tumors with Ad-αB7/IL12/GMCSF prior to DC vaccination, DCs elicited greater antitumor effects than in response to either treatment alone. DC migration to draining lymph nodes (DLNs) dramatically increased in mice treated with the combination therapy. This result was associated with upregulation of CCL21+ lymphatics in tumors treated with Ad-αB7/IL12/GMCSF. Moreover, the proportion of CD4+CD25+ T cells and VEGF expression was decreased in mice treated with the combination therapy. Furthermore, combination therapy using immature DCs also showed effective antitumor effects when combined with Ad-αB7/IL12/GMCSF. The combination therapy had a remarkable therapeutic efficacy on large tumors. Taken together, oncolytic adenovirus coexpressing IL-12 and GM-CSF in combination with DC vaccination has synergistic antitumor effects and can act as a potent adjuvant for promoting and optimizing DC vaccination. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4393. doi:1538-7445.AM2012-4393
Demonstration of a Lumbar Hernia on the Flow Phase of a Tc-99m MDP Three-Phase Bone Scan
Authors: PERRY S. GERARD, ANITA MOALLEM, ROBERT LIMANI
Journal: Clinical Nuclear Medicine (1996)

A 95-year-old woman was evaluated for possible hip fracture after she had fallen. The vascular and blood pool images of the three-phase bone scan show activity extending lateral to the abdominal wall after injection with Tc-99m MDP. The four-hour static images are clear in this area. Results of physical examination showed a nonreducible lumbar hernia of the right side of the lower abdomen, which explains the appearance of the early scans.
Treatment of Prostatic Obstruction
Authors: T. Millin
Journal: BMJ (1937)

statistical results following the use of radium have been even worse than following the operation alone.I believe, however, that very few, if any, surgeons besides myself have over a number of years employed radium, or radium combined with very conservative surgery, in the treatment of early carcinoma of the breast.In my experience the results of these methods have proved to be virtually the same as those obtained from the best surgery, and I have seen no reason for abandoning the use of radium.I hope later to be able to publish a report of the results obtained with radium up to the end of March or April of this year.Radium technique has not stood still since it began to be developed at St. Bartholomew's about twelve years ago and its value and limitations in cancer of the breast began to be fairly clear.-I am, etc.,
Na+/Ca2+ exchange current (INa/Ca) and sarcoplasmic reticulum Ca2+ release in catecholamine-induced cardiac hypertrophy
Authors: A Chorvatova
Journal: Cardiovascular Research (2003)

Catecholamines that accompany acute physiological stress are also involved in mediating the development of hypertrophy and failure. However, the cellular mechanisms involved in catecholamine-induced cardiac hypertrophy, particularly Ca2+ handling, are largely unknown. We therefore investigated the effects of cardiac hypertrophy, produced by isoprenaline, on I(Na/Ca) and sarcoplasmic reticulum (SR) function in isolated myocytes.I(Na/Ca) was studied in myocytes from Wistar rats, using descending (+80 to -110 mV) voltage ramps under steady state conditions. Myocytes were also loaded with fura-2 and either field stimulated or voltage clamped to assess [Ca2+]i and SR Ca2+ content.Ca2+-dependent, steady state I(Na/Ca) density was increased in hypertrophied myocytes (P<0.05). Ca2+ release from the SR was also increased, whereas resting [Ca2+]i and the rate of decline of [Ca2+]i to control levels were unchanged. SR Ca2+ content, estimated by using 10.0 mmol/l caffeine, was also significantly increased in hypertrophied myocytes, but only when myocytes were held and stimulated from their normal resting potential (-80 mV) but not from -40 mV. However, the rate of decline of caffeine-induced Ca2+ transients or I(Na/Ca) was not significantly different between control and hypertrophied myocytes. Ca2+-dependence of I(Na/Ca), examined by comparing the slope of the descending phase of the hysteresis plots of I(Na/Ca) vs. [Ca2+]i, was also similar in the two groups of cells.Data show that SR Ca2+ release and SR Ca2+ content were increased in hypertrophied myocytes, despite an increase in the steady state I(Na/Ca) density. The observation that increased SR function occurred only when myocytes were stimulated from -80 mV suggests that Na+ influx may play a role in altering Ca2+ homeostasis in hypertrophied cardiac muscle, possibly through increased reverse Na+/Ca2+ exchange, particularly at low stimulation frequencies.
Chemical and biochemical dosimetry of exposure to genotoxic chemicals.
Authors: G N Wogan, N J Gorelick
Journal: Environmental Health Perspectives (1985)

Epidemiologic studies designed to evaluate the health significance of environmental chemicals are compromised by the lack of quantitative exposure data for individuals in exposed populations. Monitoring data on levels of compounds in environmental media often represent the only information available, and average population exposure is therefore the only quantitative parameter that can be calculated. Biological monitoring, i.e., measurements on cells, tissues or body fluids of exposed persons, has the objective of defining the so-called
License With the Poetic
Authors: Samuel Vaisrub
Journal: JAMA (1976)

WOULD that poets showed greater interest in medicine! How often have we wished that this were so when, on scanning a poem, our eyes would be arrested by a line or a stanza with medical connotations wasted in a nonmedical context. Think of the medical potential of "Why so pale and wan fond lover/Prythee, why so pale?" A great poem on the etiology of anemia might have replaced the pretty, yet inconsequential love song, had Sir John Suckling studied medicine. Ponder how John Keats, though himself a physician, failed to make something hematologic or psychosomatic of his memorable "I saw<i>pale</i>kings and princes too/<i>Pale</i>warriors, death-<i>pale</i>were they all." Must the physician then give up for lost the little nuggets of poetry that could have been set into a medical ornament? Certainly not. He can still salvage these medical gems by quoting them out of context in
The Eosinophilia-Myalgia Syndrome: Status of 205 Patients and Results of Treatment 2 Years after Onset
Authors: Phillip A. Hertzman
Journal: Annals of Internal Medicine (1995)

Objective: To describe the course of the eosinophilia-myalgia syndrome during a 2-year period. Design: 15 physicians completed a structured review form to describe symptoms, physical findings, laboratory data, and responses to treatments in 205 patients with the eosinophilia-myalgia syndrome at the onset of illness and after 18 to 24 months of follow-up. Setting: 15 university and private clinical practice settings. Patients: 205 patients for whom follow-up data were available and who met four criteria at diagnosis: eosinophil count of 1000 cells/mm3 or greater; presence of fasciitis, peripheral neuropathy, polyradiculopathy, interstitial pulmonary disease, pulmonary hypertension, or myocardial involvement; history of l-tryptophan consumption; and absence of other conditions that could account for these findings. Intervention: Empirical interventions by the physicians. Measurements: Symptoms, physical findings, laboratory test results, biopsy findings, radiographic reports, therapeutic interventions, and responses to these interventions. Results: After 18 to 24 months, all symptoms except cognitive changes were reported to have improved in most patients. Nearly all physical findings were also reported to have improved or resolved in most patients; only peripheral neuropathy was unchanged. No evidence of ongoing inflammatory disease was reported. Prednisone was reported to be helpful in 79% of patients who received it during the acute phase of the syndrome. No other treatment was reported to be consistently beneficial. Conclusions: 18 to 24 months after the onset of illness, most symptoms and physical findings in most patients with the eosinophilia-myalgia syndrome resolved or improved. Cognitive changes were reported to be worse in 32% of patients. Prednisone was helpful in the acute phase of illness. No treatment was clearly valuable in management of the later phase of the syndrome.
A Prospective Study of Incident Squamous Cell Carcinoma of the Skin in the Nurses' Health Study
Authors: F. Grodstein, F. E. Speizer, D. J. Hunter
Journal: JNCI Journal of the National Cancer Institute (1995)

Background: Few epidemiologic studies are available that quantify the magnitude of the risk of squamous cell carcinoma (SCC) of the skin associated with sun exposure and related factors such as skin type. In addition, several studies have found an association between cigarette smoking and SCC. Purpose: We prospectively examined the risk of developing SCC in relation to phenotype and the effects of sun exposure, as well as to cigarette smoking and other factors, during 8 years of follow-up in a cohort of 107 900 predominantly white women aged 30–55 years at base line in 1976. Methods: Questionnaires regarding medical history and health-related variables were sent to Nurses' Health Study participants every 2 years, beginning in 1976. Information on constitutional factors (natural hair color, childhood and adolescent tendency to sunburn and tan, and lifetime number of severe sunburns), lifestyle factors (regular time spent outdoors in the summer and sunscreen use), the state lived in at birth and at ages 15 and 30 years, and cigarette smoking habits were ascertained by questionnaire. A total of 197 women with first-incident, histologically confirmed, invasive SCCs that were diagnosed from 1982 to 1990 were included in this analysis. Multivariate analysis using proportional hazards models was used to calculate the relative risks (RRs) and corresponding 95% confidence intervals (CIs), with adjustment for confounders. Results: The risk of SCC was increased in women living in California (RR = 1.8; 95% CI = 1.3−2.6) and Florida (RR = 2.1; 95% CI =N 1.1−3.9) at base line, compared with those living in the northeastern states. This risk was higher for women living in those states at birth and at 15 years of age (RR = 2.5; 95% CI = 1.4−4.4 for California and RR = 3.0; 95% CI = 0.7−1.2 for Florida). Red (RR = 2.0; 95% CI = 1.1−3.7) and light brown (RR = 1.7; 95% CI = 1.2−2.4) hair colors were associated with an increased risk of SCC, compared with dark brown hair. After adjusting for the number of sunburns, women who tended to burn after 2 or more hours of sun exposure as children had a slightly higher risk of SCC than those who never burned (RR = 1.5; 95% CI = 0.9−2.5 for burn and RR = 1.1; 95% CI = 0.6−2.0 for painful burn), although the actual number of severe burns appeared to be a more important factor (RR = 2.4; 95% CI = 1.5−4.0 for six or more burns). Finally, current cigarette smokers showed a 50% increase in the risk of SCC compared with never smokers (RR = 1.5; 95% CI = 1.1−2.1). Conclusion: Exposure to the sun leading to sunburn, particularly at early ages, should be avoided to decrease the risk of incident SCC. [J Natl Cancer Inst 87:1061–1066, 1995]
Pyogenic granuloma of the descending colon
Authors: T. Nakaya, T. Tokunaga, S. Aono, S. Kobari, S. Tounou, Y. Magata, K. Utsunomiya, K. Hase
Journal: Endoscopy (2007)

A 59-year-old woman who was known to have large hepatic cysts presented with a positive fecal occult blood test. Her physical examination was unremarkable, and laboratory testing revealed no abnormalities. A double-contrast barium study showed a round, radiolucent area in the descending colon. Colonoscopy revealed a light-red, sessile lesion, about 15 mm in diameter, which consisted of variously-sized nodules covered with white exudate ([Fig. 1]). The rest of the colonic mucosa was unremarkable. When the specimen was biopsied massive bleeding occurred, suggesting that the lesion was hypervascular. Histological examination of the biopsy specimen showed proliferation of capillaries.
Osteonecrosis of the jaw and bisphosphonates
Authors: A. Khan
Journal: BMJ (2010)

Low doses for osteoporosis seem to be safe

Bisphosphonate associated osteonecrosis of the jaw is defined as exposed bone in the maxillofacial region for more than eight weeks in the absence of radiotherapy but the presence of bisphosphonate use. The condition is diagnosed clinically with exclusion of local malignancy. Other conditions may present in a similar manner, and these include spontaneous sequestration or lingual mandibular sequestration and ulceration, which is characterised by exposed necrotic bone at the level of the mylohyoid ridge of the lingual mandible. This condition is self limiting and heals spontaneously within three days to 12 weeks.1 

Other important risk factors for the development of osteonecrosis include local infection, chemotherapy, steroid use, trauma, and periodontal disease.2 Bisphosphonates are commonly used in the management of skeletal complications of malignancy, and treatment with high dose bisphosphonates has been associated with an increased risk of osteonecrosis of the jaw in patients with cancer. …
INJURIES, FEIGNED AND REAL, WITH THEIR DIFFERENTIATION AND MEDICOLEGAL ASPECT.
Authors: LAMBERT OTT
Journal: JAMA (1901)

Injuries may be divided into two classes: 1, those with visible signs and symptoms; 2, those with invisible symptoms. Injury to certain tissues produce evidences of molecular change which usually justify the signs present and the symptoms complained of. A solution of continuity in either soft or bony parts requires no inductive or exclusive process of reasoning for their detection. Injuries to the nervous system productive of distinct objective symptoms, motor disturbances or discoverable sensory manifestations, do not tax the examiner's ingenuity to draw conclusions. Injuries to the nervous system, non-productive of objective symptoms in which the examiner is compelled to depend entirely upon subjective symptoms to arrive at the truth, are the most trying types the physician has to cope with. The invisible symptoms are the sensory, such as pain and the paresthesia. The visible symptoms and signs are chiefly motor and atrophic. Without repeating unnecessary detail as to
Quality of Life and Treatment Outcome in Panic Disorder: Cognitive Behavior Group Therapy Effects in Patients Refractory to Medication Treatment
Authors: Elizeth Heldt, Carolina Blaya, Luciano Isolan, Leticia Kipper, Betina Teruchkin, Michael W. Otto, Marcelo Fleck, Gisele G. Manfro
Journal: Psychotherapy and Psychosomatics (2006)

&lt;i&gt;Background:&lt;/i&gt; Improvements in quality of life (QoL) as well as symptomatic relief are important outcomes for the treatment of panic disorder (PD). The aim of this study is to assess the impact of brief cognitive behavior group therapy (CBGT) for panic disorder on QoL and to identify the clinical features associated with these changes. &lt;i&gt;Methods:&lt;/i&gt; Thirty-six patients with PD refractory to pharmacological treatment took part in a treatment protocol consisting of 12 sessions of CBGT. To evaluate the changes in QoL, the WHOQOL-bref was administered before and after treatment. &lt;i&gt;Results:&lt;/i&gt; Thirty-two patients completed the treatment. Significant improvement in all domains of QoL was observed (p&lt; 0.001), which was associated with reductions in general and anticipatory anxiety (p = 0.018) and agoraphobic avoidance (p = 0.046). Consistent with previous findings, associations between QoL and panic-free status did not reach significance in this small study (p = 0.094). &lt;i&gt;Conclusions: &lt;/i&gt;CBGT was efficacious in the treatment of PD; the symptoms of anticipatory anxiety and avoidance appear to be more important than episodic panic episodes in affecting QoL.
Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.
Authors: Ts Jeong, S L Schissel, I Tabas, H J Pownall, A R Tall, X Jiang
Journal: Journal of Clinical Investigation (1998)

Apolipoprotein E knockout (apoE0) mice accumulate atherogenic remnant lipoproteins in plasma. We now provide evidence that these particles are enriched in sphingomyelin (SM), and explore the mechanisms and possible pathophysiological consequences of this finding. The phosphatidylcholine/sphingomyelin (PC/SM) ratio was reduced in all lipoproteins in apoE0 mice compared with wild-type (Wt) mice (2.0+/-0.2 vs. 4.7+/-0.5; 2.8+/-0.5 vs. 5.5+/-0.9; 1.9+/-0. 5 vs. 4.6+/-0.5 for VLDL, LDL, and HDL), reflecting 400 and 179% increases in plasma pools of SM and PC, respectively. Turnover studies using [14C]PC/[3H]SM VLDL or HDL showed that the fractional catabolic rate (FCR) of VLDL-SM and HDL-SM were markedly reduced in the apoE0 mice compared with Wt mice, while the FCRs of VLDL-PC and HDL-PC were similar. By contrast, the FCRs of [3H]PC ether and [14C]SM were identical in apoE0 and Wt mice. The production rates of VLDL-SM and HDL-SM in apoE0 mice were much higher than in Wt mice, while the production rates of lipoprotein PC were similar. To assess the underlying mechanisms, we also measured the PC/SM ratio in VLDL and LDL of LDL receptor knockout (LDLr0) and hepatic LDL receptor-related protein knockout/LDLr0 mice, but found no difference with Wt mice. Using S-sphingomyelinase, an enzyme secreted by macrophages and endothelial cells, we found that VLDL and LDL from apoE0, but not from Wt or LDLr0 mice, were significantly aggregated, and that aggregation was not prevented by adding back apoE. We then enriched the apoE0-VLDL and Wt-VLDL with different amounts of SM, and found that VLDL aggregation was enhanced. Thus, the increased SM content of lipoproteins in apoE0 mice is due to combined synthesis and clearance defects. Impaired SM clearance reflects resistance to intravascular enzymes and delayed removal by a non-LDLr, non-LDLr related protein pathway. The increased SM content in slowly cleared remnant lipoproteins may enhance their susceptibility to arterial wall SMase and increase their atherogenic potential.
An Unusual Pigmented Lesion: What Is Your Diagnosis?
Authors: Ronald N. Shore, Allison K. Skae
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
When are adaptive motor patterns nonadaptive?
Authors: Jeffery J. Summers, Julie Thomas
Journal: Behavioral and Brain Sciences (1996)

Abstract The assumption that adaptive changes in motor patterns are optimal is questioned. Instances are cited where alteration of the adaptive motor patterns may be warranted. Other issues discussed are: (1) the relationship between central nervous system (CNS) priorities and the individual's priorities, (2) the use of cognitive bypass strategies by impaired individuals, and (3) conceiving CNS priorities as coordinative rules.
Septicaemia due to Yersinia enterocolitica after oral overdoses of iron.
Authors: K Melby, S Slordahl, T J Gutteberg, S A Nordbo
Journal: BMJ (1982)

Septicaemia occurred after accidental oral overdoses of iron in two previously healthy children. Yersinia enterocolitica serotype 0:3 was recovered from blood and stool cultures in both patients. Enhanced growth of Y enterocolitica in the intestine combined with damage of intestinal mucosa may have been of major importance for the development of generalised infection in these cases. Iron and the iron chelating agent desferrioxamine may possibly have a pathogenetic role in such circumstances.
Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia–reperfusion injury
Authors: Laura Llacuna, Anna Fernández, Claudia Von Montfort, Núria Matías, Laura Martínez, Francisco Caballero, Antoni Rimola, Montserrat Elena, Albert Morales, José C. Fernández-Checa, Carmen García-Ruiz
Journal: Journal of Hepatology (2010)
Horner's syndrome as an initial manifestation of Takayasu's arteritis
Authors: J-W Chung
Journal: Annals of the Rheumatic Diseases (2003)

Takayasu’s arteritis (TA) is a granulomatous vasculitis of the large arteries. It typically produces segmental arterial narrowing and occlusion, but aneurysm formation is uncommon.1 Subclavian artery aneurysm presenting with Horner’s syndrome is very rare.2 We report on a patient with Horner’s syndrome caused by subclavian artery aneurysm in TA.

A 37 year old Korean man was admitted because of right side ptosis and anhidrosis. He had visited the ophthalmology department three weeks previously. Initially, his margin reflex distance 1 (MRD1) was 1.5 mm (right) and 3.0 mm (left). The neostigmine test was performed, but the MRD1 did not change. After administration of phenylephrine 1 drop, however, MRD1 was improved to 3.0 mm in the right eye. Horner’s syndrome was diagnosed. He had no trauma history. He did not complain of any claudication, pain, or dizziness. His blood pressure was 110/70 mm Hg in both arms and pulse rate 80 beats/min. Complete blood counts, serum protein, and urine analysis were normal. Antinuclear …