tbuckley/cabot-search huggingface dataset:
THE DIAGNOSIS OF CUTANEOUS SYPHILIS.
Authors: ISADORE DYER
Journal: JAMA (1903)

<h3>INTRODUCTION: ANACHRONISMS IN COMMON METHOD OF DIVIDING SYPHILIS INTO ARBITRARY GROUPS OF PRIMARY, SECONDARY AND TERTIARY.</h3> The differential diagnosis of skin affections has always seemed a veritable<i>pons asinorum</i>to the practitioner, to whom all lesions look much alike and to whom the gross picture always seems present. In the types of syphilis, however, exact lines of distinction characterize every set of lesions, and the experienced recognize these at once, often without even discussing the reasons why, the picture fixing the diagnosis on its own lines. In current texts, now and latterly, so much of the traditional anachronisms have prevailed that it has seemed to the writer that some one, somewhere and somehow, should call a halt and at least utter a word against the further teaching of a dogma, which most of us feel is wrong and which as many of us would like to get away from. With
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
Authors: Wen Qiu, Min Hu, Anita Sridhar, Ken Opeskin, Stephen Fox, Michail Shipitsin, Melanie Trivett, Ella R Thompson, Manasa Ramakrishna, Kylie L Gorringe, Kornelia Polyak, Izhak Haviv, Ian G Campbell
Journal: Nature Genetics (2008)
Retrograde injections of formaldehyde into the biliary tree induce alterations of biliary epithelial function in rats
Authors: M Dumont
Journal: Hepatology (1996)

Formaldehyde may induce severe lesions of intrahepatic and extrahepatic bile ducts. The purpose of this study was to examine in vivo the functional consequences of an alteration of the biliary epithelium induced by a retrograde intrabiliary injection of formaldehyde in rats. After basal bile collection, a 10% formaldehyde solution was injected into the biliary tree of anesthetized rats, and the cannula was occluded for 30 minutes. Choleresis was then reestablished, and bile flow, bile acid, and bicarbonate secretion were measured both spontaneously and during ursodeoxycholate infusions. Formaldehyde injections induced a significant increase in bile flow and a marked inhibition of ursodeoxycholate-induced increase in biliary bicarbonate concentration and secretion. Biliary glucose secretion, which is normally very low, was increased about 20-fold in animals injected with formaldehyde. Histological and ultrastructural examination of the liver showed alterations of biliary epithelial cells, whereas hepatocytes, bile canaliculi, and canalicular tight junctions remained normal. Hepatocytic excretory function, as assessed by biliary secretion of bile acids, was not affected. It was concluded that short-term formaldehyde intrabiliary injections cause an inhibition of ursodeoxycholate-induced hypersecretion of bicarbonate, an increase in biliary glucose secretion, and selective structural alterations of biliary epithelial cells. These results suggest that formaldehyde retrograde biliary injection may be a useful model to study alterations of biliary epithelial function in vivo.
Stimulation of thrombopoiesis in mice by human recombinant interleukin 6.
Authors: R J Hill, M K Warren, J Levin
Journal: Journal of Clinical Investigation (1990)

To date, testing of various cytokines for the stimulation of blood cell production has not demonstrated a consistent effect on peripheral platelet levels. In this report, we provide evidence that human recombinant IL-6 increased platelet production in mice, as measured by both peripheral platelet levels and [75Se]selenomethionine (75SeM) incorporation into newly forming platelets. Peripheral white blood cell counts also were increased, but only to a modest extent, and hematocrit values were unchanged. A dose-response relationship between the amount of IL-6 administered and platelet count, 75SeM incorporation, and white blood cell count was demonstrated. Detectable megakaryocyte and granulocyte-macrophage colony-forming cells in mice that had received IL-6 also were increased in both bone marrow and spleen. These results demonstrate the ability of a purified, recombinant protein to stimulate platelet production in vivo.
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
Authors: Kensuke Noma, Yoshiyuki Rikitake, Naotsugu Oyama, Guijun Yan, Pilar Alcaide, Ping-Yen Liu, Hongwei Wang, Daniela Ahl, Naoki Sawada, Ryuji Okamoto, Yukio Hiroi, Koichi Shimizu, Francis W. Luscinskas, Jianxin Sun, James K. Liao
Journal: Journal of Clinical Investigation (2008)

Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular diseases, the tissue- and isoform-specific roles of ROCKs in the vascular response to injury are not known. To address the role of ROCKs in this process, we generated haploinsufficient Rock1 (Rock1(+/-)) and Rock2 (Rock2(+/-)) mice and performed carotid artery ligations. Following this intervention, we found reduced neointima formation in Rock1(+/-) mice compared with that of WT or Rock2(+/-) mice. This correlated with decreased vascular smooth muscle cell proliferation and survival, decreased levels proinflammatory adhesion molecule expression, and reduced leukocyte infiltration. In addition, thioglycollate-induced peritoneal leukocyte recruitment and accumulation were substantially reduced in Rock1(+/-) mice compared with those of WT and Rock2(+/-) mice. To determine the role of leukocyte-derived ROCK1 in neointima formation, we performed reciprocal bone marrow transplantation (BMT) in WT and Rock1(+/-) mice. Rock1(+/-) to WT BMT led to reduced neointima formation and leukocyte infiltration following carotid ligation compared with those of WT to WT BMT. In contrast, WT to Rock1(+/-) BMT resulted in increased neointima formation. These findings indicate that ROCK1 in BM-derived cells mediates neointima formation following vascular injury and suggest that ROCK1 may represent a promising therapeutic target in vascular inflammatory diseases.
Howard Earle Skipper: In Memoriam (1915–2006)
Authors: Linda Simpson-Herren, Glynn P. Wheeler
Journal: Cancer Research (2006)

Howard Earle Skipper died at his residence in Mountain Brook, Alabama on January 2, 2006 at age 90. He was born on November 21, 1915 at Avon Park, Florida to Chesley Allen Skipper and Estelle Wiggins Skipper. He grew up in Sebring, Florida, and in his youth he worked on his father's cattle ranch and
Zinc sulphate and bedsores.
Authors: D. F. Abbott, A. N. Exton-Smith, P. H. Millard, J. M. Temperley
Journal: BMJ (1968)

cover, or that loose or infected teeth were involved ?If the treatment provided was only fillings performed in a sound mouth would the authors consider that the relation- ship of dental treatment to the onset of the disease might be fortuitous, especially since it was not possible to isolate the causative organisms to give further evidence ?The answer to this question is of great importance in view of the number of patients for whom dental surgeons routinely provide an antibiotic umbrella before the removal of teeth, but not before filling them.-Iam, etc.,
The role of I-J and Igh determinants on F1-derived suppressor factor in controlling restriction specificity.
Authors: M Minami, I Aoki, N Honji, C R Waltenbaugh, M E Dorf
Journal: The Journal of Experimental Medicine (1983)

In the 4-hydroxy-3-nitrophenyl acetyl (NP) contact sensitivity system, the activity of third-order suppressor cells and their factors is restricted by H-2(I-J) and Igh linked genes. The present report analyzes the specificity of NP-specific Ts3 cells and factors derived from H-2 and Igh heterozygous (B6 X C3H)F1 mice. Two approaches were used. First, heterogeneous populations of F1 Ts3 cells were activated in vitro and then assayed in Ts3-depleted recipients which carried different combinations of H-2 and Igh alleles. The second approach was to hybridize the Ts3 cells and analyze the specificity of the F1-derived TsF3. The combined data demonstrated four functionally distinct populations of Ts3 cells. The activity of each population was restricted by a particular combination of H-2 and Igh haplotypes. Thus, Ts3 cells derived from F1 donors can demonstrate an apparent scrambling of H-2 and Igh restriction specificities. There was functional allelic exclusion of the H-2(I-J) and Igh determinants expressed on (B6 X C3H)F1 hybridoma-derived TsF3. Thus, TsF3 from each cloned hybridoma line expressed only one set of I-J and Igh determinants. Furthermore, there was a complete correlation between the I-J and Igh linked determinants expressed on TsF3 and the restriction specificity. In view of the recent findings on the molecular biology of the I-J region, an alternative interpretation of the role of I-J determinants on suppressor cells and factors is offered.
University of Toronto is criticised for study of homeopathy in ADHD
Authors: O. Dyer
Journal: BMJ (2015)

A study by University of Toronto researchers looking at homeopathic treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) has been criticised in a letter signed by 90 scientists and doctors. They say they are concerned that “the mounting of such a study by a highly reputable researcher at a top notch university will be used by homeopaths to justify diverse aspects of their practice, including steering patients away from evidence-based treatments.”

The trial, which is registered with the US National Institutes of Health,1 is being conducted by a team led by the dean of the Leslie Dan Faculty of Pharmacy, Heather Boon. It is currently recruiting 177 patients aged 6 to 16 years into three double blinded treatment arms: homeopathic consultation and medicine, homeopathic consultation and placebo, and a no treatment group.

The letter originated in the Office for Science and Society of McGill University …
C-11-METHYL-TRIPHENYLPHOSPHONIUM (C-11-MTP), A NEW AGENT FOR IMAGING MYOCARDIAL CONTRACTILITY
Authors: B J Krause, R F Dannals, H T Ravert, Z Szabo, I GOzCikara, U Scheffel, H N Wagner
Journal: Clinical Nuclear Medicine (1992)

Krause, B J; Dannals, R F; Ravert, H T; Szabo, Z; Gözükara, I; Scheffel, U; Wagner, H N Jr. Author Information
Cardiac conduction abnormalities during percutaneous balloon mitral or aortic valvotomy.
Authors: M D Carlson, I Palacios, J D Thomas, J N Rottman, C S Freeman, P C Block, J N Ruskin, H Garan
Journal: Circulation (1989)

To evaluate the electrophysiologic changes in the cardiac conduction system that occur during percutaneous mitral or aortic balloon valvotomy, we prospectively studied the conduction system in 19 patients (10 mitral, 8 aortic, and 1 both) undergoing this procedure. A His bundle electrogram was recorded in all patients, and when sinus rhythm was present, the atrioventricular (AV) node effective refractory period was measured. Holter monitoring was performed during and for 24 hours after the procedure. Follow-up electrocardiograms (ECG) were available in 11 patients 2.3 +/- 1.5 months after the procedure. The AV node effective refractory period before (276 +/- 86 msec) and after valvotomy (298 +/- 85 msec) were not significantly different. The maximum His-Purkinje conduction time (HV interval) observed during valvotomy (66 +/- 20 msec) was significantly longer (p less than 0.01) than that measured before (57 +/- 10 msec) or after (60 +/- 18 msec) valvotomy. The mean HV intervals before and after valvotomy were not significantly different. The mean QRS complex duration increased from 95 +/- 28 to 112 +/- 28 msec during valvotomy and remained significantly prolonged (109 +/- 26 msec) 24 hours after the procedure (p less than 0.01). A new intraventricular conduction defect (QRS complex duration greater than 100 msec) or bundle branch block occurred in five of 13 patients who had normal QRS duration before the procedure. The change in HV interval did not correlate with the change in QRS complex duration. In four patients, the newly acquired intraventricular conduction defect was still present on follow-up ECG tracing. Complete heart block was not observed in any patient.(ABSTRACT TRUNCATED AT 250 WORDS)
Resonance within and between linguistic beings
Authors: Stephen D. Goldinger, Tamiko Azuma
Journal: Behavioral and Brain Sciences (2004)

Pickering & Garrod (P&G) deserve appreciation for their cogent argument that dialogue merits greater scientific consideration. Current models make little contact with behaviors of dialogue, motivating the interactive alignment theory. However, the theory is not truly "mechanistic." A full account requires both representations and processes bringing those representations into harmony. We suggest that Grossberg's (1980) adaptive resonance theory may naturally conform to the principles of dialogue.
ABNORMAL HAIR SHAFTS IN PSORIASIS ON SCANNING ELECTRON MICROSCOPY*
Authors: EDWARD WYATT, EVA BOTTOMS, STANLEY COMAISH
Journal: British Journal of Dermatology (1972)

Journal Article ABNORMAL HAIR SHAFTS IN PSORIASIS ON SCANNING ELECTRON MICROSCOPY Get access EDWARD WYATT, EDWARD WYATT University Department of Dermatology and Wellcome Laboratories for Research into SkinUDisease, Royallcia l Victoria Infirmary, Newcastle‐upon‐Tyne, NE1 4LP Search for other works by this author on: Oxford Academic Google Scholar EVA BOTTOMS, EVA BOTTOMS University Department of Dermatology and Wellcome Laboratories for Research into SkinUDisease, Royallcia l Victoria Infirmary, Newcastle‐upon‐Tyne, NE1 4LP Search for other works by this author on: Oxford Academic Google Scholar STANLEY COMAISH STANLEY COMAISH University Department of Dermatology and Wellcome Laboratories for Research into SkinUDisease, Royallcia l Victoria Infirmary, Newcastle‐upon‐Tyne, NE1 4LP Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 4, 1 October 1972, Pages 368–373, https://doi.org/10.1111/j.1365-2133.1972.tb07424.x Published: 01 October 1972 Article history Accepted: 03 May 1972 Published: 01 October 1972
The Bracelin, A Chlorin Solution Only.
Authors: J. J. Russell
Journal: JAMA (1896)

Chicago, May 26, 1896. <h3>To the Editor:</h3> —In a recent issue of theJournalI noticed that Dr. Martin Matter is again not only assailing Bracelin's bactericide, but indulging himself in a series of sinister-handed compliments concerning me personally. A wily but unscrupulous old lawyer at one time was giving what he termed " valuable pointers " to a younger member of the profession in handling a jury, which were as follows: If the facts in the case are in your favor and the law against you, stick to the facts and say nothing about the law. If the law is in your favor and the facts against you, stick to the law and disregard the facts. If the law and the facts are both against you, ignore both and vigorously abuse your opponent and his client. In this way you will take the minds of the jurors away from the merits
Function of Ahnak protein in aortic smooth muscle cell migration through Rac activation
Authors: Hee Jung Lim, Dong Hoon Kang, Jung Mi Lim, Dong Min Kang, Je Kyung Seong, Sang Won Kang, Yun Soo Bae
Journal: Cardiovascular Research (2012)

Ahnak protein acts as a scaffold protein networking phospholipase C-γ and protein kinase C-α, which subsequently stimulate an extracellular signal-regulated kinase (Erk) pathway. In mouse aortic smooth muscle cells (ASMCs), the activation of the signalling cascade ultimately promotes the cell migration through an unknown mechanism. We aimed to dissect the Ahnak-mediated cell signalling network involved in the migration of ASMCs.Migration of ASMCs from wild-type mice was significantly increased by platelet-derived growth factor (PDGF) stimulation in transwell chamber and wound-healing assays, whereas migration of ASMCs from Ahnak knockout mice was reduced. Consistently, stimulation of wild-type ASMCs with PDGF resulted in Rac activation-mediated lamellipodial protrusion in migrating cells. In contrast, Ahnak knockout ASMCs displayed lower activation of Rac in response to PDGF and slow lamellipodial protrusion rate and cell migration. Ahnak signalling complex was analysed by immunoprecipitation with antibody to p21-activated protein kinase (PAK). Ahnak protein was shown to function as the signalling scaffold interacting with the multiple protein complex of Erk, PAK, and p21-activated kinase-interacting exchange factor β. The proposed role of Ahnak in cell migration was examined using a restenosis model in which the carotid arteries of mice were subjected to post-ligation injury. We show neointimal formation and SMC migration after ligation injury in Ahnak knockout mice were significantly retarded compared with wild-type mice.Ahnak protein plays an important scaffolding function connecting Erk and Rac activation in PDGF-dependent migration of ASMC.
Administrative case rounds. Institutional policies and leaders cast in a different light
Authors: S. J. Reiser
Journal: JAMA (1991)

GOVERNING the institutions of health care provision is becoming increasingly difficult. This is largely caused by an accelerating pace of technological innovation that alters their financial status and internal structure, a growing number of constituencies in society that demand authority to influence institutional policies, and a widening gap between the professional and administrative staff of institutions concerning goals and purpose. To better cope with these issues, institutional leaders should recognize and learn to fulfill effectively the pedagogic role they take on for their staff and constituents when they create and carry out policy. They also should consider holding regular discussions about institutional policy alternatives within the framework of one of the most significant and powerful means of teaching and research in medicine—the case round.  In reaching decisions, administrators who govern health care institutions, such as hospitals or health science centers, frequently separate the policies developed to guide institutional action from
Extra Time for New Scrip Pads
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of EGFR Mutation Status in Lung Adenocarcinoma Specimens with Different Proportions of Tumor Cells Using Two Methods of Differential Sensitivity
Authors: Hye-Suk Han, Sung-nam Lim, Jin Young An, Ki Man Lee, Kang Hyeon Choe, Ki Hyeong Lee, Seung Taik Kim, Seung-Myoung Son, Song-Yi Choi, Ho-chang Lee, Ok-Jun Lee
Journal: Journal of Thoracic Oncology (2011)
Protein-Sulfhydryl Groups In Cell Control Mechanisms
Authors: Frances E. Knock
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Sensitivity tests on hundreds of animal and human cancers have shown greater attack on cancers than normal tissues by selected drugs reacting with sulfhydryl (SH) groups, drugs termed SH inhibitors.<sup>1-3</sup>Nature herself appears to control cell division by regulating SH groups.<sup>4</sup> Cancer probably devolves to derangement of regulatory mechanisms for mitosis about which little is known except that very large numbers of chemical reactions must occur simultaneously or in interrelated sequence for mitosis to occur. Either huge numbers of separate regulatory mechanisms and separate chemical receptors for regulators may be involved, or a single common chemical denominator may be crucial in turning on and off the host of reactions. Because of its inherent simplicity, the latter hypothesis may be the more probable.<sup>3,4</sup> Protein-SH groups play essential roles at multiple levels of cell control processes. To earlier data<sup>1-5</sup>on the importance of protein-SH groups
Quality Improvement Ethics: Lessons From the SUPPORT Study
Authors: Benjamin S. Wilfond
Journal: The American Journal of Bioethics (2013)

The Office of Human Research Protections was not justified in issuing findings against the SUPPORT Institutions. Our community can learn from the evolving healthcare transformation into learning health systems by thinking about the novel ethical issues about standard of care research raised by the SUPPORT with the same spirit of quality improvement. The current regulatory framework and the concept of foreseeable research risks is insufficient to advance the debate about the ethics of randomization of standard clinical interventions. This article uses the example of the Wisconsin cystic fibrosis randomized clinical trial for newborn screening trial to explore the distinctions between risks of research and clinical care and waivers of informed consent for randomization. Collaborative exploration of these complex policy issues is needed and further deliberation, community engagement, and social science research will be critical to advance novel approaches for informed consent.
IgG is associated with the asialoglycoprotein receptor in the human liver
Authors: Takashi Inamoto, William R. Brown
Journal: Hepatology (1991)

Various pathophysiological relationships between IgA and the asialoglycoprotein receptor on hepatocytes have been proposed. As a step toward defining these relationships, we purified the receptor from human livers by means of p-aminophenyl β-D-thiogalactopyranoside-agarose affinity chromatography. Unexpectedly, we found the asialoglycoprotein receptor to be associated specifically with IgG. Evidence for the specific association included the following: (a) IgG, but little IgA or IgM, was associated with asialoglycoprotein receptor that had been bound to asialoorosomucoid in an enzyme-linked immunosorbent assay; (b) the asialoglycoprotein receptor–associated IgG was predominantly IgG2 and IgG4 subclasses, whereas serum IgG is predominantly IgG1; and (c) some asialoglycoprotein receptor was specifically recovered together with IgG from an anti-IgG affinity column. The association of IgG with asialoglycoprotein receptor was not mediated by receptor recognition of carbohydrate moieties because IgG neither bound directly to asialoglycoprotein receptor nor inhibited binding of asialoglycoprotein receptor to asialoorosomucoid in vitro. The association could not be attributed to antigen-antibody interaction either. We conclude that IgG is associated in vitro with the asialoglycoprotein receptor by a mechanism not yet fully defined and speculate that the IgG serves an immunological function. (HEPATOLOGY 1991;14:1070–1075.)