tbuckley/cabot-search huggingface dataset:
An echocardiographic study of interventricular septal motion in the Wolff-Parkinson-White syndrome.
Authors: G S Francis, P Theroux, R A O'Rourke, A D Hagan, A D Johnson
Journal: Circulation (1976)

Echocardiographic studies of interventricular septal motion were performed in 26 consecutive patients with the Wolff-Parkinson-White (WPW) syndrome and in ten normal subjects. All patients with types A or B pre-excitation were subclassified into groups I to IV on the basis of their electrocardiogram utilizing the method of Boineau and associates. In all 14 patients with type A (Group III or IV) pre-excitation, the motion of the interventricular septum and posterior left ventricular wall motion were normal. However, in 11 patients with type B (Group I) WPW an abnormal septal movement was noted. This was characterized in ten patients by an early systolic posterior motion, a subsequent anterior movement in mid systole, and the usual posterior septal motion beginning in late systole. In eight patients, including the one without early systolic posterior movement of the septum, the late systolic posterior movement was interrupted by a prominent septal notch. On e patient with type B (Group II) WPW was studied and exhibited normal septal and posterior wall motion. In one patient with a spontaneous change in the QRS complex from normal to a type B (Group I) WPW pattern, the septal motion was initially normal and abruptly changed following the first WPW beat. The onset of abnormal interventricular septal motion with type B pre-excitation QRS complexes strongly suggests that abnormal septal movement may be related to an altered sequence of ventricular depolarization during right ventricular pre-excitation.
Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice.
Authors: L Oberst, G Zhao, J T Park, R Brugada, L H Michael, M L Entman, R Roberts, A J Marian
Journal: Journal of Clinical Investigation (1998)

Hypertrophic cardiomyopathy (HCM) is a disease of sarcomeric proteins. The mechanism by which mutant sarcomeric proteins cause HCM is unknown. The leading hypothesis proposes that mutant sarcomeric proteins exert a dominant-negative effect on myocyte structure and function. To test this, we produced transgenic mice expressing low levels of normal or mutant human cardiac troponin T (cTnT). We constructed normal (cTnT-Arg92) and mutant (cTnT-Gln92) transgenes, driven by a murine cTnT promoter, and produced three normal and five mutant transgenic lines, which were identified by PCR and Southern blotting. Expression levels of the transgene proteins, detected using a specific antibody, ranged from 1 to 10% of the total cTnT pool. M-mode and Doppler echocardiography showed normal left ventricular dimensions and systolic function, but diastolic dysfunction in the mutant mice evidenced by a 50% reduction in the E/A ratio of mitral inflow velocities. Histological examination showed cardiac myocyte disarray in the mutant mice, which amounted to 1-15% of the total myocardium, and a twofold increase in the myocardial interstitial collagen content. Thus, the mutant cTnT-Gln92, responsible for human HCM, exerted a dominant-negative effect on cardiac structure and function leading to disarray, increased collagen synthesis, and diastolic dysfunction in transgenic mice.
Indications for Lumbar Puncture-Reply
Authors: Herbert N. Hultgren
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RAB7 Controls Melanoma Progression by Exploiting a Lineage-Specific Wiring of the Endolysosomal Pathway
Authors: Direna Alonso-Curbelo, Erica Riveiro-Falkenbach, Eva Pérez-Guijarro, Metehan Cifdaloz, Panagiotis Karras, Lisa Osterloh, Diego Megías, Estela Cañón, Tonantzin G Calvo, David Olmeda, Gonzalo Gómez-López, Osvaldo Graña, Víctor Javier Sánchez-Arévalo Lobo, David G Pisano, Hao-Wei Wang, Pablo Ortiz-Romero, Damià Tormo, Keith Hoek, José L Rodríguez-Peralto, Johanna A Joyce, María S Soengas
Journal: Cancer Cell (2014)
Protecting the Public Health by Strengthening the Food and Drug Administration's Authority over Tobacco Products
Authors: M L Myers
Journal: New England Journal of Medicine (2000)

For years, public health experts hypothesized that cigarettes that had less tar would also be less hazardous. However, recent studies have actually shown an increase in the relative risk of all major smoking-related diseases among smokers, even though most cigarettes now contain far less tar than those that were on the market 40 years ago.1 One reason may be that the tobacco companies designed these newer cigarettes to reduce the tar levels that are measured by the machine-generated tests sanctioned by the government without affecting the actual intake of tar by smokers and without regard to the level of specific . . .
PGC-1α Induces SPP1 to Activate Macrophages and Orchestrate Functional Angiogenesis in Skeletal Muscle
Authors: Glenn C. Rowe, Srilatha Raghuram, Cholsoon Jang, Janice A. Nagy, Ian S. Patten, Amrita Goyal, Mun Chun Chan, Laura X. Liu, Aihua Jiang, Katherine C. Spokes, David Beeler, Harold Dvorak, William C. Aird, Zolt Arany
Journal: Circulation Research (2014)

Rationale : Mechanisms of angiogenesis in skeletal muscle remain poorly understood. Efforts to induce physiological angiogenesis hold promise for the treatment of diabetic microvascular disease and peripheral artery disease but are hindered by the complexity of physiological angiogenesis and by the poor angiogenic response of aged and patients with diabetes mellitus. To date, the best therapy for diabetic vascular disease remains exercise, often a challenging option for patients with leg pain. Peroxisome proliferation activator receptor-γ coactivator-1α (PGC-1α), a powerful regulator of metabolism, mediates exercise-induced angiogenesis in skeletal muscle. Objective : To test whether, and how, PGC-1α can induce functional angiogenesis in adult skeletal muscle. Methods and Results : Here, we show that muscle PGC-1α robustly induces functional angiogenesis in adult, aged, and diabetic mice. The process involves the orchestration of numerous cell types and leads to patent, nonleaky, properly organized, and functional nascent vessels. These findings contrast sharply with the disorganized vasculature elicited by induction of vascular endothelial growth factor alone. Bioinformatic analyses revealed that PGC-1α induces the secretion of secreted phosphoprotein 1 and the recruitment of macrophages. Secreted phosphoprotein 1 stimulates macrophages to secrete monocyte chemoattractant protein-1, which then activates adjacent endothelial cells, pericytes, and smooth muscle cells. In contrast, induction of PGC-1α in secreted phosphoprotein 1 −/− mice leads to immature capillarization and blunted arteriolarization. Finally, adenoviral delivery of PGC-1α into skeletal muscle of either young or old and diabetic mice improved the recovery of blood flow in the murine hindlimb ischemia model of peripheral artery disease. Conclusions : PGC-1α drives functional angiogenesis in skeletal muscle and likely recapitulates the complex physiological angiogenesis elicited by exercise.
Abstract 3510: The molecular docking-based design and biological evaluation of a novel series of bisintercalating DNA-binding bisanthrapyrazole compounds containing amine linkers
Authors: Xing Wu, Rui Zhang, Lynn Guziec, Frank Guziec, Jack C. Yalowich, Brian B. Hasinoff
Journal: Cancer Research (2010)

Abstract Anticancer drugs that bind to DNA and inhibit DNA-processing enzymes represent an important class of anticancer drugs. In order to find stronger DNA binding and more potent cytotoxic compounds, a series of bisanthrapyrazole derivatives containing amine linkers were designed and evaluated by molecular docking techniques. Because the anthrapyrazoles are unable to be reductively activated like doxorubicin and other anthracyclines, they should lack the cardiotoxicity exhibited by this class of antitumor agent. The concentration dependent increase in DNA melting temperature was used to determine the strength of DNA binding and the bisintercalation potential of the newly synthesized analogs. These compounds were also assessed for their ability to inhibit: 1) the growth of the human erythroleukemic K562 cell line; 2) the decatenation activity of DNA topoisomerase IIα; 3) the relaxation activity of DNA topoisomerase I. Finally, the compounds were evaluated as topoisomerase IIα poisons by measuring the topoisomerase IIα-mediated double strand cleavage of DNA. All of the bisanthrapyrazoles inhibited K562 cell growth in the low to submicromolar concentration range and also strongly inhibited the decatenation activity of topoisomerase IIα. However, none of the bisanthrapyrazole compounds act as topoisomerase IIα poisons. In conclusion, a novel group of bisanthrapyrazole compounds were designed, synthesized, and biologically evaluated as potential anticancer agents. Support: CIHR, a Canada Research Chair in Drug Development to B.B.H., a National Institutes of Health grant CA090787 to J.C.Y. and the Dishman Foundation at Southwestern University. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3510.
A Standardized Triglyceride and Carbohydrate Challenge
Authors: Nina Mohanlal, Rury R. Holman
Journal: Diabetes Care (2004)

RESULTS — The drink was consumed within 3 min and well tolerated by all subjects. The median triglyceride rise at 6 h was similar in diabetic and nondiabetic subjects (0.23 vs. 0.42 mmol/l, NS) and correlated with glucose increase a t2h( r 0.429, P 0.018 and r 0.509, P 0.026; respectively). Diabetic subjects had higher 6-h geometric mean (1 SD range) triglyceride levels (1.82 [1.87 to 3.23] vs. 1.11 [0.66 to 1.11 mmol/l], P 0.003) but a similar coefficient of variation (17.5 vs. 17.0%, NS) and a similar median (interquartile range) time to achieve maximal concentration (Tmax) (6.0 [4.0 to 6.0] vs. 5.0 [4.0 to 6.0] h, NS). Capillary triglyceride values were equivalent to simultaneous venous samples but consistently 10% greater. CONCLUSIONS — The OTTT permits simple evaluation of postchallenge triglyceride levels, is acceptable to subjects, and can be performed with capillary sampling. It could be used to monitor triglyceride-lowering therapies and to provide additional information concerning cardiovascular disease risk, particularly in diabetic subjects. Diabetes Care 27:89 –94, 2004
TRANS-AORTIC IMPLANTATION OF THE MEDTRONIC COREVALVE PROSTHESIS. SUCCESSFUL IMPLANTATION THROUGH AN ALTERNATIVE ACCESS ROUTE
Authors: Ulrich Gerckens, Ralf Mueller, Stein Iversen, Thomas Felderhoff, Barthel Sauren, Bernfried Zickmann, Lutz Buellesfeld, Eberhard Grube
Journal: Journal of the American College of Cardiology (2010)
Germany considers "sting" operations to catch retailers selling alcohol to underage youths
Authors: N. Stafford
Journal: BMJ (2010)

Support is growing in Germany’s Bundestag for a new law giving legal cover to sting operations against retailers that sell alcoholic beverages to underage young people.

Thomas Jarzombek, a “youth expert” in the Bundestag and a member of Chancellor Angela Merkel’s centre right Christian Democratic Union, said that a few local authorities in Germany are already using underage people to participate in what he and other supporters of the practice call “test purchases.”

However, current German law does not provide guidelines or legal cover for such operations, making a new law necessary, he said. 

Mechthild Dyckmans, Germany’s federal drug commissioner, who is based in the Health Ministry, …
Relationships among Folate, Allergic Sensitization, Wheezing, and Asthma
Authors: A.Y. Okupa, E.C. Matsui, J.E. Gern, D.J. Jackson, M.D. Evans, R.E. Gangnon, K.A. Roberg, C.J. Tisler, R.F. Lemanske
Journal: Journal of Allergy and Clinical Immunology (2010)
Antibiotic use varies widely across intensive care units
Authors: R. Dobson
Journal: BMJ (2003)

Big international differences in antibiotic use in hospital intensive care units have been found by researchers.

The researchers, who surveyed more than 200 intensive care units in 34 countries, say the results show that policies on optimal antibiotic prescribing for critically ill patients are urgently needed.

“We documented a wide variation in antibiotic prescribing practice for bacteraemia in intensive care unit patients that is too wide to fit the hypothesis that all observed approaches are appropriate,” said the authors of a report published online in the Journal of Antimicrobial Chemotherapy (www.jac.oupjournals.org), in advance of the print version.

They continued: “This survey …
Assessment of water use for estimating exposure to tap water contaminants.
Authors: G H Shimokura, D A Savitz, E Symanski
Journal: Environmental Health Perspectives (1998)

Epidemiological studies examining the association between exposure to tap water contaminants (such as chlorination by-products) and disease outcomes (such as cancer and adverse reproductive outcomes) have been limited by inaccurate exposure assessment. Failure to take into account the variation in beverage and tap water consumption and exposure to volatile contaminants through inhalation and dermal absorption can introduce misclassification in assessing the association between exposure to tap water contaminants and health. To refine exposure assessment of tap water contaminants, we describe in detail the tap water consumption, showering, and bathing habits of pregnant women and their male partners as assessed by a questionnaire and a 3-day water diary. We found good agreement between questionnaire and 3-day water diary values for drinking water intake (Pearson's r = 0.78) and for time spent showering(r = 0.68) and bathing (r = 0.78). Half of the participants consumed tap water on a regular basis with an overall mean +/- 1 standard deviation (SD) of 0. 78 +/- 0.51 l/day. Our results further suggest that full-time employees, compared to women working part-time or less, have more heterogeneous consumption patterns over time. Seventy-nine percent of women and 94% of men took showers for an average of 11.6 +/-4.0 min and 10.4 +/- 4.8 min, respectively. Baths were taken more frequently by women than men (21% vs. 3%) for an average of 22.9 +/-10.1 min and 21.3 +/- 12.4 min, respectively. Thus, these patterns of tap water use should be considered in the design and interpretation of environmental epidemiology studies.
CASE OF PRIMARY SYPHILITIC LESION OF THE FAUCIAL TONSIL.
Authors: GEORGE C. STOUT
Journal: JAMA (1901)

This was done on Monday; the patient returned on Thursday to have the dressings changed.There was not the slightest discharge of pus from the cavity, the mucous membrane having the appearance of always hav- ing lived there ; it was redressed the same as before.On Friday the patient, to have her children go to school clean, did some washing of their clothes, which from the motion partly displaced one of the strips, and on Monday the loose end was cut off.She wore the shell night and day for two months, re-
Environmental and bronchoalveolar lavage Dermatophagoides pteronyssinus antigen levels in atopic asthmatics.
Authors: P Ferguson, D H Broide
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Overnight environmental home exposure to Dermatophagoides pteronyssinus in IgE-sensitized individuals is often clinically associated with increased morning symptoms of rhinitis and/or asthma. We have investigated whether household exposure to D. pteronyssinus is associated with the presence of immunoreactive D. pteronyssinus I antigen (Der p I) in bronchoalveolar lavage (BAL) fluid in nine atopic asthmatics sensitized to D. pteronyssinus. Significant environmental concentrations of D. pteronyssinus were noted by light microscopy and immunoassay in the subjects' bedroom carpets (13.4 +/- 3.8 micrograms immunoreactive Der p I/g dust), mattresses (27.3 +/- 7.2 micrograms immunoreactive Der p I/g dust), and living room carpets (5.9 +/- 1.5 micrograms immunoreactive Der p I/g dust). Immunoreactive Der p I was measurable in 20-fold concentrated BAL fluids (3.4 +/- 1.0 ng/ml concentrated BAL fluid) after overnight home exposure. A 24-h hospitalization in a D. pteronyssinus controlled environment (< 0.02 micrograms Der p I/g dust) resulted in a significant decrease in BAL Der p I concentrations (0.8 +/- 0.6 ng/ml). In vivo studies in nine asthmatics challenged endobronchially with D. pteronyssinus (5-60 ng Der p I) induced significant airway eosinophilia. These studies demonstrate that environmental exposure to microgram amounts of D. pteronyssinus is associated with airway recovery of small nanogram amounts of Der p I.
The dangers of good intentions
Authors: I Robertson
Journal: BMJ (1994)

It is 1939 in urban Massachusetts. A group of social workers and social psychologists devise a plan which will take young delinquents off the streets and give them a stake in society. The scientists among them, however, insist that, though the scheme is self evidently worth while and of benefit to the boys, there must be a control group against which to compare the benefits of this programme of counselling and practical help.

Seven hundred boys are therefore randomly assigned to a control group and to an experimental group respectively. The fortunate 50% receive a twice monthly visit from a counsellor and get …
LONG-TERM OUTCOME OF USE OF ORAL ANTICOAGULANTS WITH DUAL ANTIPLATELET THERAPY IN PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION AND NEW ONSET SYSTOLIC DYSFUNCTION
Authors: Smita Negi, Nevin Baker, Michael Lipinski, Thibault Lhermusier, Hideaki Ota, Sarkis Kiramijyan, Edward Koifman, Ricardo Escarcega Alarcon, Marco Magalhaes Pereira, Rebecca Torguson, Itsik Ben-Dor, William Suddath, Augusto Pichard, Lowell Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2015)
PREDICTORS OF DEFECT-FREE COMPLIANCE WITH PROCESS MEASURES IN PATIENTS PRESENTING WITH ACUTE MYOCARDIAL INFARCTION: INSIGHTS FROM GET WITH THE GUIDELINES CAD
Authors: Dharam J. Kumbhani, Gregg C. Fonarow, Christopher C. Cannon, Adrian F. Hernandez, Eric D. Peterson, W. Frank Peacock, Warren K. Laskey, Wenqin Pan, Lee H. Schwamm, Deepak L. Bhatt
Journal: Journal of the American College of Cardiology (2011)
GW25-e5315 Antithrombotic Therapy in Chinese Patients with Atrial Fibrillation: Results from a multicenter, prospective Registry
Authors: Zhang Han, Zhu Jun, Shao Xinghui, Liu Yao, Zhao Li, Yu Pengfei, Zhang Hua, He Qing, Gu Xiaodan, Yang Yanmin
Journal: Journal of the American College of Cardiology (2014)
Clonal Selection in Malignant Transformation of Human Fibroblasts Transduced with Defined Cellular Oncogenes
Authors: Alka M. Mahale, Zahid A.T. Khan, Makoto Igarashi, Gouri J. Nanjangud, Rui Fang Qiao, Shen Yao, Sam W. Lee, Stuart A. Aaronson
Journal: Cancer Research (2008)

Abstract Recent evidence has implied that disruption of a limited number of defined cellular pathways is necessary and sufficient for neoplastic conversion of a variety of normal human cell types in tissue culture. We show instead that malignancy in such models results from an iterative process of clonal selection in vitro and/or in vivo. Normal human fibroblasts underwent malignant transformation after transduction with telomerase, cyclin-dependent kinase 4, dominant-negative p53, and activated Ras or MEK. Furthermore, culture conditions favoring overgrowth resulted in clonal selection, which with added Ras or MEK oncogenes led to the emergence of tumorigenic clones. Such tumors showed variable degrees of malignancy with some even exhibiting metastasis. SV40 small t antigen (ST) has been reported to be necessary and sufficient to convert human fibroblasts with these pathway aberrations to a polyclonal tumor. However, we observed that clonal tumors emerged even with ST addition. Genomic instability was markedly increased by p53 and Rb pathway abrogation. Under the same conditions, fibroblasts with these alterations failed to induce tumors, implying that genomic instability may be necessary but not sufficient for malignant transformation. These findings indicate that the minimum number of events required for malignant transformation of human fibroblasts is greater than has been enumerated by such oncogene addition strategies and support a stochastic cancer progression model initiated by four defined cellular alterations. [Cancer Res 2008;68(5):1417–26]
Fansidar in malaria prophylaxis.
Authors: D J Bradley, A P Hall, W Peters, D Warhurst
Journal: BMJ (1985)

Fansidar in malaria prophylaxis DJ Bradley, FRCPATH, and others. 136 Missed pill conception: fact or fiction? Y Tayob, mrcog, and J Guillebaud, frcog; M A Shaw, PHD, and others . 136 Secretion of antidiuretic hormone in hyponatraemia: not always ''inappropriate S D Slater, frcp, and G Canning, mrcp. 137 Failure of the random zero sphygmomanometer in general practice B M Wright, mb; C R Hayler; Gillian A C Hosie, MB, and J Hosie, MB. 137 Which component of sulphasalazine is active in rheumatoid arthritis? R D Situnayake, MB, and B McConkey, frcp ... 138 Do sex hormones affect colorectal cancer? WSL Stebbings, frcs, and others; I G Conn, frcs, and others. 138 Hepatitis B virus DNA in saliva, urine, and seminal fluid of carriers of hepatitis B e antigen A E Dobbin, MB. 138 Short course chemotherapy for tuberculosis of lymph nodes S K Malik, MD, and D Behera, md. 139 Rational drug treatment of dementia? RLevy. 139 Garlic and blood lipids E Ernst, md, and others . 139 Loving the vacuum Sheila Sheerin, mrcpath . 139 Frozen shoulder T D Bunker, frcs. 140 Unrecognised depression in general practice G R Glover, mrcpsych. 140 Acute appendicitis and infectious mononucleosis BThalayasingam, mrcp. 140 Delayed puberty Shirley G Ratcliffe, frcped, and G Butler, mb; J Taranger, md . 141 Should all casualty radiographs be reviewed? NDuignan,MRCGP,andJTLawson,FRCR. 141 Haemoperfusion in chloroquine poisoning R Gamier, md, and J Elmalem, md. 141 Misleading false positives J M Stuart, MB. 141 Smoking before surgery: the case for stopping P V Cole, ffarcs, and Y Saloojee. 142 Blood pressure before and after operation M O'Connor, ffarcs, and M Blackwell, mrcgp 142 Alarming patients AVeitch. 142
Allergen Sensitivities and Obstruction Indices Among Inner City Asthmatic Patients with High IgE (30-700 IU/ml) Vs Ultra-High IgE Levels (&gt;700 IU/ml)
Authors: Jamie Zacharias, Edward S. Schulman, Rebanta Chakraborty, Rozina Ali, Natasha Mehta
Journal: Journal of Allergy and Clinical Immunology (2014)
Sonic Hedgehog-Induced Functional Recovery After Myocardial Infarction Is Enhanced by AMD3100-Mediated Progenitor-Cell Mobilization
Authors: Jérôme Roncalli, Marie-Ange Renault, Jörn Tongers, Sol Misener, Tina Thorne, Christine Kamide, Kentaro Jujo, Toshikazu Tanaka, Masaaki Ii, Ekaterina Klyachko, Douglas W. Losordo
Journal: Journal of the American College of Cardiology (2011)