Multiple Myeloma
Authors: Donald R. Korst, Eugene P. Frenkel, John C. Nixon
Journal: Annals of Internal Medicine (1964)

Article1 February 1964Multiple MyelomaStudies of Mouse Plasma Cell Tumor and Human Myeloma Responsiveness to Cyclophosphamide (Cytoxan)DONALD R. KORST, M.D., F.A.C.P., EUGENE P. FRENKEL, M.D., JOHN C. NIXON, M.D.DONALD R. KORST, M.D., F.A.C.P.Search for more papers by this author, EUGENE P. FRENKEL, M.D.Search for more papers by this author, JOHN C. NIXON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-217 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMultiple myeloma, a neoplasm of plasma cell origin represents a difficult therapeutic problem. Preliminary clinical trials with a new alkylating agent cyclophosphamide*(1) suggested that palliative responses in human multiple myeloma could be obtained. Investigations of myeloma have been limited by the lack of a suitable animal prototype; however, in 1957, Potter, Fahey, and Pilgrim (2) observed a plasma cell tumor in the iliocecum of C3H mice and successfully transferred the tumor subcutaneously through many generations. The tumor in mice produces bone marrow, liver, and spleen plasma cell invasion. Changes in the serum proteins are similar to the human disease....References1. KORSTJOHNSONFRENKELCHALLENER DRFDEPWL: Preliminary evaluation of the effect of cyclophosphamide on the course of human neoplasm. Cancer Chemother. Rep. 7: 1, 1960. Google Scholar2. POTTERFAHEYPILGRIM MJLHI: Abnormal serum protein and bone destruction in transmissible mouse plasma cell neoplasm (multiple myeloma). Proc. Soc. Exp. Biol. Med. 94: 327, 1957. CrossrefMedlineGoogle Scholar3. COBAUKORST CDDR: Alterations of gamma globulin with plasma cell neoplasm in mice. Proc. Soc. Exp. Biol. Med. 101: 356, 1959. CrossrefMedlineGoogle Scholar4. 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NIXON, M.D.Affiliations: Ann Arbor, MichiganFrom the Department of Hematology and Cancer Chemotherapy of St. Joseph Mercy Hospital, and the Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan.This is the Preliminary Report presented at the Forty-third Annual Meeting of the American College of Physicians, Philadelphia, Pennsylvania, April, 1962.Requests for reprints should be addressed to Donald R. Korst, M.D., 326 North Ingalls Street, Ann Arbor, Michigan.*Cyclophosphamide is an ester of phosphamide and the active alkylating group of nitrogen mustard. The drug is available in Europe as Endoxan, in Canada as Protoxan and in the U. S. as Cytoxan® (Meade-Johnson and Company). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCyclophosphamide immunosuppression does not permit successful myoblast allotransplantation in mouseA plasma clot culture system for growing and antiproliferative drug sensitivity testing of myeloma stem cellsLiteraturverzeichnisParaproteinämische HämoblastosenMelphalan and prednisone: An effective combination for the treatment of multiple myelomaSerum ribonuclease in multiple myelomaMonoclonal gammopathy with hyperlipidemiaCyclophosphamideDie therapie der ParaproteinämienZur Lebenserwartung unbehandelter und behandelter PlasmozytomkrankerClinical and metabolic investigations of eight cases of multiple myeloma during prolonged cyclophosphamide administrationAggregation of IgG globulin in vivoScientific Methodology in Clinical Medicine III. The Evaluation of Therapeutic ResponseALVAN R. FEINSTEIN, M.D. 1 February 1964Volume 60, Issue 2_Part_1Page: 217-230KeywordsCancer chemotherapyCyclophosphamideDrugsHospital medicineMultiple myelomaMyelomaPlasma cellsProteinsSpleenTumor resection ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...