tbuckley/cabot-search huggingface dataset:
Procainamide and Acute Arthritis
Authors: MARSHALL TAD MORGAN
Journal: Annals of Internal Medicine (1973)

Letters1 November 1973Procainamide and Acute ArthritisMARSHALL TAD MORGAN, M.D.MARSHALL TAD MORGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-750 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Long-term procainamide therapy commonly produces a lupus-like syndrome (1). In reported cases this complication has occurred after a minimum of 1 month's duration of therapy (1, 2), and prolonged exposure to the drug is thought to be necessary for its production (3, 4). I wish to report a case in which, on two occasions, arthritis developed within hours of procainamide administration.A 38-year-old black man entered the hospital on 18 February 1973, with an acute, extensive anterolateral myocardial infarction. He had no previous history of heart disease or arthritis and was taking no medications. He did well,...References1. DUBOIS E: Procainamide induction of a systemic lupus erythematosus-like syndrome. Presentation of six cases, review of the literature and follow-up of reported cases. Medicine (Baltimore) 48:217-228, 1969 CrossrefMedlineGoogle Scholar2. BLOMGRENCONDEMIVAUGHAN SJJ: Procainamide-induced lupus erythematosus. Clinical and laboratory observations. Am J Med 52:338-348, 1972 CrossrefMedlineGoogle Scholar3. ALARCÓN-SEGOVIA D: Drug-induced lupus syndromes. Mayo Clin Proc 44:664-681, 1969 MedlineGoogle Scholar4. SWARBRICKGREY EI: Systemic lupus erythematosus during treatment with procainamide. Br Heart J 34:284-288, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARSHALL TAD MORGAN, M.D.Affiliations: Division of Cardiology Department of Medicine Harbor General Hospital Torrance, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacologic therapy of ventricular arrhythmias 1 November 1973Volume 79, Issue 5Page: 750-750KeywordsArthritisCardiovascular therapyDrug therapyMyocardial infarction ePublished: 1 December 2008 Issue Published: 1 November 1973 PDF downloadLoading ...
Abstract 2320: A multi-domain fusion molecule inhibits tumor growth affecting <i>in-vivo</i> angiogenesis
Authors: Chandra Shekhar Boosani, Venugopal Gunda, Rajkumar Verma, Sudhakar Akul Yakkanti
Journal: Cancer Research (2012)

Abstract Growth of solid tumors beyond their benign size largely depends on the availability of oxygen and food supply which is accomplished through induced tumor angiogenesis. Inhibition of such de novo angiogenesis should aid in arresting the growth of solid tumors. Besides availability of several monoclonal antibodies and synthetic inhibitors for target molecules that induce tumor angiogenesis, endogenous antiangiogenic molecules are effective candidates with no drug resistance. Several endogenous angioinhibitors have been identified and were proven to inhibit tumor angiogenesis both in-vitro and in-vivo. However, many of them exhibited varied effects in inhibiting tumor growth with multiple mechanism(s) of action. Thus in our present study we developed a fusion antiangiogenic molecule “Combostatin” using the functional domains from two of the known antiangiogenic molecules reported by us. Here we show that Combostatin is an effective inhibitor of angiogenesis and inhibits tumor growth in-vitro and in-vivo. We also show that Combostatin affects several of the antiangiogenic pathways such as endothelial cell proliferation, migration and tube formation which are mediated by its binding to several integrin receptors on the endothelial cell surface. Our studies conclude that Combostatin is a more potent inhibitor of tumor angiogenesis than its parent molecules generated form type IV and Type XVIII collagen. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2320. doi:1538-7445.AM2012-2320
1268 CD1D-mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells in interferon-gamma independent manner and induces the activation of acquired immunity against murine hepatocellular carcinoma
Authors: T MIYAGI, T TAKEHARA, T SUZUKI, M JINUSHI, C OHNISHI, T TATSUMI, N HIRAMATSU, T KANTO, N HAYASHI
Journal: Hepatology (2003)

The beginning of hepatitis C virus (HCV) molecular virology heralds to the late 1980s with the identification of HCV as the causative agent for what was termed non-A non-B hepatitis. The complementary DNA (cDNA) clone generated in this landmark work has provided the basis for the classification and molecular dissection of HCV. Infectious consensus clones of a variety of HCV genotypes have been generated. Initial examination of these HCV sequences led to the classification of this virus as a member of the diverse Flaviviridae family of enveloped, positive strand RNA viruses. HCV represents the sole member of the Hepacivirus genus within this family. It is worth noting that the Flaviviridae family also contains the genera Flavivirus and Pestivirus, which contain numerous important human and animal pathogens, respectively. The HCV genome consists of an RNA molecule of approximately 9.6 kb containing a single open reading frame (ORF) flanked by large, highly structured 5´ and 3´ non-translated regions (NTRs). The viral RNA lacks both a 5´ cap structure and a 3´ poly (A) tail. Viral proteins are translated as a polyprotein via an internal ribosome entry site (IRES) located within the 5´ NTR. The organization of the polyprotein is similar to that of the other members of the Flaviviridae family, with structural proteins located at the 5´ end of the genome, and non-structural proteins downstream. The polyprotein processing is complex and involves both host and viral proteinase activities to carry out the numerous co- and post-translational cleavage events in the maturation of the viral proteins.
Identification of oleosins as major allergens in sesame seed allergic patients
Authors: V. Leduc, D. A. Moneret‐Vautrin, J. T. C. Tzen, M. Morisset, L. Guerin, G. Kanny
Journal: Allergy (2006)

Background: The prevalence of sesame allergy is increasing in European countries. Cases of severe allergy lack any evidence of specific immunoglobulin (Ig)Es by prick tests and CAPSystem‐FEIA. The reasons for this negativity are unknown. Methods: In 32 patients displaying immediate symptoms such as anaphylactic shock, asthma, urticaria, angioedema, sesame allergy was diagnosed by double‐blind placebo‐controlled food challenge (DBPCFC) or convincing clinical history. However, 10 patients had negative prick tests and CapSystem‐FEIA. The specificity of IgEs was further investigated by enzyme‐linked immunosorbent assay (ELISA), isoelectrofocalisation (IEF)‐blotting, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE) blotting using total sesame extracts and purified fraction of oil bodies. Monospecific rabbit antibodies directed to two oleosin isoforms (15 and 17 kDa) were used. Results: By ELISA, white sesame seed extract allowed the detection of higher levels of IgE than brown sesame extract. In all sera, numerous bands binding IgEs were detected by IEF or SDS‐PAGE. In reducing conditions, two bands (15–17 kDa), could be separated from 2S albumin. Oleosins, present in oil bodies fractions, were recognized by IgEs from all sera. Conclusion: Oleosins are major allergens of sesame seeds and may be relevant to severe anaphylaxis. Falsely negative prick tests could be due to the lack of oleosins in presently available extracts, or to the fact that epitopes might be buried in the inner molecule. Detection tests currently used to identify sesame allergens based on sesame vicillins or other storage proteins could be insufficient for the detection of sesame seed contamination. Oleosins have been named Ses i 4 (17 kDa) and Ses i 5 (15 kDa), in accordance with the IUIS Nomenclature Committee.
Interleukin-1 but not tumour necrosis factor α synergistically upregulates the granulocyte-macrophage colony-stimulating factor-induced B7-1 expression of murine Langerhans cells
Authors: M. FURUE, C.H. CHANG, K. TAMAKI
Journal: British Journal of Dermatology (1996)

Epidermal Langerhans cells (LC) express several co-stimulatory molecules such as B7/BB1, which has been implicated as one of the important determinants for potent antigen-presenting function of LC. Recent studies have shown that B7/BB1 antigens comprise three distinct molecules termed B7-1, B7-2 and B7-3. Previous studies have revealed that the phenotypic and functional properties of murine LC are enormously affected by various cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-1 (IL-1), and tumour necrosis factor alpha (TNF-alpha) derived from surrounding keratinocytes. We have already demonstrated that the expression of B7-1 of murine LC is significantly enhanced by GM-CSF, IL-1 or TNF-alpha. In this paper, we present that IL-1, but not TNF-alpha, synergistically up-regulates the GM-CSF-induced B7-1 expression of murine LC.
INSTRUMENT TO FACILITATE THE PLACING OF DRAINAGE IN AFTER-TREATMENT OF SUPPURATIVE APPENDICITIS.
Authors: A. E. SPALDING
Journal: JAMA (1902)

The effort to place drainage at the bottom of the sinus after removal of the primary drain is sometimes difficult and often painful to the patient. As the gauze adheres to the sides of the sinus, considerable force has to be used before it can be properly carried to the bottom of the cavity. The necessity for an instrument for the purpose of facilitating the placing of drainage led to a crude production which I hammered out of a white metal spoon and which I have frequently used during the past four years. Having demonstrated to my own satisfaction the practicability of such an instrument, I have recently had made for me a set of four instruments, ¾, ⅝, ½ and ⅜ of an inch in diameter by 5 inches in length. The large size is the one ordinarily used for the first dressing, diminishing the size as the sinus
Replication of duck hepatitis B virus in primary duck hepatocytes and its dependence on the state of differentiation of the host cell
Authors: Peter R. Galle, Hans-jürgen Schlicht, Christa Kuhn, Heinz Schaller
Journal: Hepatology (1989)

Primary duck hepatocytes obtained from Pekin ducks congenitally infected with duck hepatitis B virus were used to monitor expression of viral proteins and replication of viral DNA in cell culture. Duck hepatitis B virus core antigen, duck hepatitis B virus pre-surface antigen and duck hepatitis B virus DNA were detectable for at least 12 days after cell plating. Whereas expression of duck hepatitis B pre-surface antigen was constant during this time, expression of duck hepatitis B core antigen and of viral DNA rapidly declined. This diminished production of viral components in vitro was paralleled by a change of the hepatocytes toward a fibroblast-like morphology. Supplementation of cell culture medium with 2% dimethyl sulfoxide, a solvent known to maintain the differentiated state of cultured cells, retained competence of the cultured hepatocytes to express duck hepatitis B core antigen and duck hepatitis B virus DNA at high levels. In a second set of experiments, duck hepatitis B virus negative hepatocytes were infected with duck hepatitis B virus from serum of congenitally infected ducks. Dimethyl sulfoxide remarkably improved the competence of cultured duck hepatocytes to become productively infected. This function was maintained for at least 12 days postplating.
A narrow escape from splenectomy.
Authors: L Jones, S N Davies, A C Newland, G C Jenkins
Journal: BMJ (1985)

change, or the specific recommendations that the panel "took into consideration" any of this research.Clearly, policy considerations are becoming central to the debate on diet and disease.The moment of promised government action is almost upon us.The 1984 COMA panel was therefore correct to consider the practical implications of its recommendations.If it failed to do so adequately that is no cause for a retreat back into purely scientific committee work.On the contrary, it is cause for a serious effort to investigate and explicate the policy options for achieving desirable dietary change.Apart from the Bradford project, our research effort on this front is meagre.When the 1984 COMA panel wanted to review the evidence on diet and cardiovascular disease it had over 600 published scientific papers available to it.There is no equivalent body of research on the policy side, and the panel's recommendations suffered from the lack.If we begin now with a national programme of research into nutrition policy we might just be ready to help by the time the next COMA panel prepares its report.
Mapping, cloning and genetic characterization of the region containing the Wilson disease gene
Authors: K. Petrukhin, S. G. Fischer, M. Pirastu, R.E. Tanzi, I. Chernov, M. Devoto, L. M. Brzustowicz, E. Cayanis, E. Vitale, J. J. Russo, D. Matseoane, B. Boukhgalter, W. Wasco, A. L. Figus, J. Loudianos, A. Cao, I. Sternlieb, O. Evgrafov, E. Parano, L. Pavone, D. Warburton, J. Ott, G. K. Penchaszadeh, I. H. Scheinberg, T.C. Gilliam
Journal: Nature Genetics (1993)
Gastric aspiration and lavage in acute poisoning.
Authors: H. Matthew, T. F. Mackintosh, S. L. Tompsett, J. C. Cameron
Journal: BMJ (1966)

Ampicillin and Pneumonia BtRII 1333 hospital is £5 2s.8d., which is a little more than a 14-day course of ampicillin in the dosage used in this trial.It would seem, then, that in ampicillin the physician has a useful addition to his armamentarium for the treatment of pneumonia. SummaryA controlled trial was carried out to compare the use of ampicillin with a combination of penicillin and streptomycin in the treatment of pneumonia.Seventy-eight patients were allocated to the ampicillin group, in which the regime was oral ampicillin 250 mg.six-hourly for 7 or 14 days.Sixty- seven were allocated to the penicillin/streptomycin group, in which the regime required injections of penicillin 1 mega unit b.d. for 7 or 14 days with streptomycin 1 g.b.d. for the first seven days.The treatment groups were comparable, and the results of treatment were similar in the two groups.The only difference of statistical significance was that a larger proportion of cases infected with pneumococci alone became afebrile with- in one week when treated with ampicillin than when treated with penicillin and streptomycin.Ampicillin appears to be at least as effective as penicillin and streptomycin even in the comparatively small doses used in this trial.There would appear to be an advantage in domiciliary practice in using a drug that can be given by mouth, and if an allowance is made for the cost of giving injections there is little difference in the expense.
High‐density lipoprotein fails to inhibit serotonin‐induced activation of blood platelets
Authors: Olaf Pfennig, Bin Zhao, Sabine Frye, Rolf Dierichs
Journal: American Journal of Hematology (1995)

Abstract High‐density lipoprotein (HDL) of 100–400 μg/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1–5 μM). Highly concentrated HDL (1,200 μg/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist‐induced platelet activation.
SH2D1A mutations in Japanese males with severe Epstein-Barr virus–associated illnesses
Authors: Ryo Sumazaki, Hirokazu Kanegane, Maki Osaki, Takashi Fukushima, Masahiro Tsuchida, Hiroyoshi Matsukura, Kentaro Shinozaki, Hiroshi Kimura, Akira Matsui, Toshio Miyawaki
Journal: Blood (2001)
Evaluation of an electrochemical sensor for measuring blood ketones.
Authors: H A Byrne, K L Tieszen, S Hollis, T L Dornan, J P New
Journal: Diabetes Care (2000)

OBJECTIVE: To evaluate the performance of a hand-held ketone sensor that is able to measure blood beta-hydroxybutyrate (beta-HBA) concentrations within 30 s in patients with diabetic ketoacidosis (DKA) and patients who attend a weight management clinic. RESEARCH DESIGN AND METHODS: Two groups of patients were studied: 19 patients admitted with DKA and 156 patients attending a weight management clinic. Paired capillary and venous whole blood samples were measured using the ketone sensor and also using an enzymatic laboratory reference method. RESULTS: The ketone sensor accurately measured beta-HBA concentrations in patients with DKA (limits of agreement -0.9 to + 1.0 mmol/l) or starvation-induced ketonemia (limits of agreement -0.5 to +0.5 mmol/l). CONCLUSIONS: This ketone sensor accurately measures whole blood beta-HBA concentrations within 30 s.
Use of aspirin in secondary prevention of coronary heart disease is rising
Authors: A J Carney, T A Carney
Journal: BMJ (1996)

EDITOR,—We can confirm Ray King and Jonathan Denne's findings of an increased use of low dose aspirin in secondary prevention of cardiovascular disease1 and have a suggestion for why there may be a difference in the prevalence of such treatment between the sexes and how this might be overcome.

Throughout 1994 and 1995 the Burn Brae Medical Group, a practice of six partners with 8200 patients in a market town, carried out three audits of the subject. A computer search followed …
Cardiac Denervation in Diabetes
Authors: T. Wheeler, P. J. Watkins
Journal: BMJ (1973)

Evidence for vagal denervation of the heart as a feature of diabetic autonomic neuropathy has been obtained by monitoring beat-to-beat variation in heart rate. Nine diabetics with autonomic neuropathy were assessed; each showed a marked reduction or absence of beat-to-beat variation in comparison with controls. Beat-to-beat variation in normal subjects is abolished by parasympathetic blockade but unaffected by sympathetic blockade. These findings suggest that spontaneous vagal denervation of the heart was present in the cases studied. Measurement of beat-to-beat variation provides a simple test whereby cases of autonomic neuropathy can be screened for cardiac involvement.
America's Gulag Archipelago
Authors: Norman Fost
Journal: New England Journal of Medicine (2004)

If you were to meet Fred Boyce today, you might think he was a normal person, aside from the fact that he is better looking and more charming than most of us. He has been a successful entrepreneur for most of his adult life. He was married to — though subsequently divorced from — a woman with graduate degrees from Harvard and the University of Massachusetts. His reading interests range from Carl Sagan's Cosmos to Isaac Asimov to Somerset Maugham.But Fred Boyce is not normal. Indeed, in some ways, he is extraordinary. At the age of eight, after years . . .
A frame shift mutation in the PMP22 gene in hereditary neuropathy with liability to pressure palsies
Authors: Garth A. Nicholson, Linda J. Valentijn, Annia K. Cherryson, Marina L. Kennerson, Tara L. Bragg, Robert M. DeKroon, David A. Ross, John D. Pollard, James G. Mcleod, Pieter A. Bolhuis, Frank Baas
Journal: Nature Genetics (1994)
Bilateral injuries in childhood: an alerting sign.
Authors: S A Laing, A R Buchan
Journal: BMJ (1976)

single cases A epidemic outbreaks 0 endemic occurrence Incidence of single cases * and epidemics A, and endemic El occurrence of typhoid fever due to S typhi with R-factor-mediated resistance to chloramphenicol and other antibiotics throughout the world, 1967-74.3
PSYCHIATRIC FACILITIES IN PRISONS AND CORRECTIONAL INSTITUTIONS IN THE UNITED STATES
Authors: WARREN S. WILLE
Journal: American Journal of Psychiatry (1957)

On the basis of this survey in 1954, only 43 psychiatrists were working full-time and 39 part-time in the 167 prisons and reformatories of the United States and possessions. In addition to this small group, there were 51 working in a consultant capacity. However, some of these rendered only token services to the prisons by making visits less frequently than once a month. Twenty-four states plus the Territory of Hawaii had no psychiatric facilities in their prisons, or else had no services except for occasional visits by psychiatric consultants. It is obvious that the psychiatric study of the criminal offender is still a largely neglected field. Despite the increasing recognition that many repetitive offenders are mentally ill and that criminal behavior stems from unconscious conflicts, very few criminals actually receive thorough psychiatric study or treatment. The level of care rendered to the mentally ill person in the prisons of many states is still at no higher a level than was common in the average asylum of 100 years ago. From the humanitarian standpoint alone, the level of care provided to the mentally ill in prison should be made to approximate that given in the average state hospital. There is no less a need for additional research in this field, inasmuch as the average state now has to allow as much in its budget for the care of criminal offenders as for the maintenance of its mental institutions. Settle(7) feels that the best way to better treatment for the abnormal offender is through the expansion of psychiatric services in the correctional system rather than through changing concepts of criminal responsibiilty. This is the most that can be hoped for at present, since it will certainly be some time before there is any widespread change in the concept of criminal responsibility which would permit a sizeable proportion of such offenders to be screened out in the courts and sent to hospitals for psychiatric treatment( 7, 8).
Myocardial Ischemia Induces Interleukin-6 and Tissue Factor Production in Patients With Coronary Artery Disease
Authors: Ignatios Ikonomidis, George Athanassopoulos, John Lekakis, Kyriaki Venetsanou, Margarita Marinou, Kimon Stamatelopoulos, Dennis V. Cokkinos, Petros Nihoyannopoulos
Journal: Circulation (2005)

Interleukin-6 (IL-6) and macrophage colony stimulating factor plasma levels are elevated in acute coronary syndromes. IL-6 has an inherent negative inotropic action and, with tissue factor (TF), mediates the ischemia-reperfusion myocardial injury. We hypothesized that inducible ischemia leads to cytokine production, TF expression, and consequently persistent left ventricular dysfunction after dobutamine stress echocardiography (DSE) in coronary artery disease patients.DSE was performed in 103 patients with angiographically documented coronary artery disease. Blood samples were obtained at rest, at peak stress, and 30 minutes after cessation of dobutamine infusion for measurement of macrophage colony stimulating factor, IL-6, and TF. New or worsening wall motion abnormalities at peak stress and their duration into recovery were noted. Median IL-6 and TF levels were increased at peak stress and at 30 minutes into recovery compared with rest (2.7 and 2.4 versus 2.1 pg/mL for IL-6, 310 and 385 versus 266 pg/mL for TF [P<0.01] in patients with an ischemic response; n=55). Compared with rest, a greater release of IL-6 at peak stress and recovery was observed in patients with increasing number of ischemic segments at peak DSE (2 versus 3 to 4 versus 5 to 6 versus 7 to 8 segments; P=0.03). The time to recovery of wall motion abnormalities was also associated with IL-6 levels at peak stress and recovery (r=0.51 and r=0.39, P<0.05). Macrophage colony stimulating factor levels remained unchanged throughout DSE.Reversible ischemia induced during DSE increases IL-6 and TF plasma levels. IL-6 is related to the extent of left ventricular dysfunction at peak stress and to persistent LV dysfunction during recovery.