tbuckley/cabot-search huggingface dataset:
Commentary: Biologics for psoriasis: steps to heaven 17
Authors: C.E.M. Griffiths
Journal: British Journal of Dermatology (2012)

Journal Article Commentary: Biologics for psoriasis: steps to heaven 17 Get access C.E.M. Griffiths C.E.M. Griffiths The Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester M6 8HD, U.K. E‐mail: christopher.griffiths@manchester.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 167, Issue 4, 1 October 2012, Pages 715–716, https://doi.org/10.1111/bjd.12026 Published: 01 October 2012
Expression of T-lineage-affiliated transcripts and TCR rearrangements in acute promyelocytic leukemia: implications for the cellular target of t(15;17)
Authors: Elise Chapiro, Eric Delabesse, Vahid Asnafi, Corinne Millien, Frederic Davi, Elizabeth Nugent, Kheira Beldjord, Torsten Haferlach, David Grimwade, Elizabeth A. Macintyre
Journal: Blood (2006)
Revalidating retired doctors
Authors: M. Vickers
Journal: BMJ (2001)

About two years ago, after the General Medical Council (GMC) had made it clear that it was going to press ahead with revalidation, its president, Sir Donald Irvine, visited Cardiff to sell the whole concept to the medical establishment and the National Assembly for Wales. I could not resist asking if he was going to stop me signing passport photographs. He thought for a moment and said that there might have to be a special section of the register for retired doctors which enumerated their remaining privileges. In which case, I said, would that include being able to prescribe a mild sedative to members of the family? This question was obviously too difficult for him; his only response was that I should not be doing it anyway.

> We just want to be able to prescribe a limited range of drugs to a limited range of people 

I do not know how many retired doctors there are. No one does. It must be well in excess of 10 000 considering how many retire early. Since Sir Donald's visit I, for one, …
Direct Arterial Pressure and Electrocardiogram during Motor Car Driving
Authors: W. A. Littler, A. J. Honour, P. Sleight
Journal: BMJ (1973)

Direct arterial pressure and electrocardiogram have been measured continuously over a period of 24 hours in 15 patients. Observations have been made on the behaviour of these variables during 30 separate episodes of motor car driving. The patients were divided into three groups: (1) five normotensive subjects, (2) five patients with essential hypertension who were not receiving therapy, and (3) five patients with angina pectoris who were either normotensive or hypertensive. In all but one subject, apart from variable changes in heart rate, no significant arrhythmias or S-T segment changes were observed in the electrocardiogram. The arterial pressure remained remarkably stable throughout the driving period in all three groups and there was no significant difference between the levels of blood pressure at the beginning and end of a journey. There were short periods of raised arterial pressure during driving related to such episodes as overtaking, but these quickly returned to baseline levels. Two patients experienced anginal pain during driving. It is concluded that motor car driving does not have such a pronounced effect on the blood pressure as might have been thought.
Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.
Authors: S Goto, Y Ikeda, E Saldívar, Z M Ruggeri
Journal: Journal of Clinical Investigation (1998)

Platelet aggregation contributes to arresting bleeding at wound sites, but may cause occlusion of atherosclerotic vessels, thus curtailing blood flow to vital organs. According to current dogma, the integrin alphaIIbbeta3 plays an exclusive role in linking platelets to one another through interactions with fibrinogen or vWf. We demonstrate here that, depending on shearing flow conditions, this process may require vWf binding to glycoprotein Ibalpha, even when alphaIIbbeta3 is competent to bind adhesive ligands. Platelet activation induced solely by high shear stress is initiated by glycoprotein Ibalpha interaction with vWf, but results in aggregation only if the latter can bind concurrently to alphaIIbbeta3. In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur. Thus, the latter interaction appears to provide a bond with biomechanical properties necessary to overcome the effects of high shear rate and initiate interplatelet cohesion. These findings highlight the distinct function of two adhesive receptors mediating platelet aggregation under varying fluid dynamic conditions, and modify the current interpretation of a crucial event in hemostasis and thrombosis.
Expert witness claimed that a defendant had "intermittent explosive disorder," GMC hears
Authors: C. Dyer
Journal: BMJ (2010)

<h3>Abstract</h3> The field of microbiology has experienced significant growth due to transformative advances in technology and the influx of scientists driven by a curiosity to understand how microbes interact with each other and their environment to sustain myriad biochemical processes that are essential for maintaining the Earth. With this explosion in scientific output, a significant bottleneck has been the ability to disseminate this new knowledge to peers and the public in a timely manner. Preprints have emerged as a tool that a growing number of microbiologists are using to overcome this bottleneck. Furthermore, posting preprints can help to transparently recruit a more diverse pool of reviewers prior to submitting to a traditional journal. Although use of preprints is still limited in the biological sciences, early indications are that preprints are a robust tool that can complement and enhance peer-reviewed publications. As publishing moves to embrace advances in internet technology, there are many opportunities for preprints and peer-reviewed journals to coexist in the same ecosystem.
Abnormalities of sleep in patients with the chronic fatigue syndrome.
Authors: R Morriss, M Sharpe, A L Sharpley, P J Cowen, K Hawton, J Morris
Journal: BMJ (1993)

OBJECTIVE--To determine whether patients with the chronic fatigue syndrome have abnormalities of sleep which may contribute to daytime fatigue. DESIGN--A case-control study of the sleep of patients with the chronic fatigue syndrome and that of healthy volunteers. SETTING--An infectious disease outpatient clinic and subjects9 homes. SUBJECTS--12 patients who met research criteria for the chronic fatigue syndrome but not for major depressive disorder and 12 healthy controls matched for age, sex, and weight. MAIN OUTCOME MEASURES--Subjective reports of sleep from patients9 diaries and measurement of sleep patterns by polysomnography. Subjects9 anxiety, depression, and functional impairment were assessed by interview. RESULTS--Patients with the chronic fatigue syndrome spent more time in bed than controls (544 min v 465 min, p &lt; 0.001) but slept less efficiently (90% v 96%, p &lt; 0.05) and spent more time awake after initially going to sleep (31.9 min v 16.6 min, p &lt; 0.05). Seven patients with the chronic fatigue syndrome had a sleep disorder (four had difficulty maintaining sleep, one had difficulty getting to sleep, one had difficulty in both initiating and maintaining sleep, and one had hypersomnia) compared with none of the controls (p = 0.003). Those with sleep disorders showed greater functional impairment than the remaining five patients (score on general health survey 50.4% v 70.4%, p &lt; 0.05), but their psychiatric scores were not significantly different. CONCLUSIONS--Most patients with the chronic fatigue syndrome had sleep disorders, which are likely to contribute to daytime fatigue. Sleep disorders may be important in the aetiology of the syndrome.
Individualized Care for Patients with Cancer — A Work in Progress
Authors: Robert C. Bast, Gabriel N. Hortobagyi
Journal: New England Journal of Medicine (2004)

During the past two decades, molecular biologists have been dissecting the heterogeneity of human cancer — a diversity that oncologists have long appreciated, especially because patients who have similar stages and grades of cancer and whose tumors have similar histologic features have a broad range of clinical outcomes. Some cancers respond to treatment; others do not. Some patients have a recurrence of cancer; others are cured.Molecular markers promise the ability to estimate prognoses and predict responses to particular treatments with greater precision than is possible with clinical findings. With further refinement of molecular diagnostics, the care of patients with . . .
Pneumococcal Vaccine and Splenectomy
Authors: Saeed Ahmad
Journal: JAMA (1980)

To the Editor.—  Regarding the answer in the QUESTIONS AND ANSWERS section by Theodore H. Spaet, MD (242:1413, 1979), I want to comment on the efficacy of pneumococcal vaccine in the spleenless patients.  General studies and reports pertinent to the value of the vaccine in asplenic patients have been published. Asplenic patients are at increased risk from infections caused by encapsulated bacteria, particularlyStreptococcus pneumoniae, Haemophilus influenzaetype B, andNeisseria meningitidis. Overwhelming postsplenectomy infection has been noted in all clinical conditions associated with absence of splenic function. The clinical course is frequently fulminant, leading to disseminated intravascular coagulation and death.  Sullivan et al1studied immune response in nine patients aged 4 to 37 years who had undergone splenectomy after trauma. All of these patients demonstrated significant seroconversion in response to pneumococcal polysaccharide antigen.  Since the majority of cases of overwhelming postsplenectomy infection are caused byS pneumoniae, all
Dermo—epidermal adhesion and its effect on epidermal structure in the mouse
Authors: WILLIAM S. BULLOUGH, JOHANNA U.R. DEOL
Journal: British Journal of Dermatology (1975)

SUMMARY Evidence is presented that dermo—epidermal adhesion is low in mouse ear. Consequently the pressure caused by mitotic activity in the basal epidermal layer is readily relieved by cell extrusion distally and the number of basal cells per unit skin area remains low. The rule then is that the number of distal cells per unit skin area must be equally low, and the epidermis is therefore thin. Conversely, dermo—epidermal adhesion is high in mouse sole-of-foot epidermis, and the mitotic pressure leads through cell crowding to a columnar basal epithelium. Furthermore, in the footpad centre, where adhesion is evidently highest, the baseline folds. With basal cell crowding and baseline folding there are more basal cells, and therefore more distal cells, per unit skin area. The epidermis is thick. Epidermal cells are regarded as equipotential. The different epidermal characteristics of the different body regions are determined by the combined actions of the local mitotic rate and the local strength of the dermal grip.
Neutrophilic panniculitis with myelodysplastic syndromes presenting as pustulosis: Case report and review of the literature
Authors: Hsiang‐Cheng Chen, Woei‐Yau Kao, Deh‐Ming Chang, Hong‐Wei Gao, Wei‐Yu Lai, Jenn‐Haung Lai
Journal: American Journal of Hematology (2004)

Abstract Neutrophilic panniculitis associated with myelodysplastic syndromes is rare. We report a 59‐year‐old patient who initially was diagnosed with myelodysplastic syndrome (MDS) and developed a sudden onset of widespread pustulosis and erythematous indurated papules. Examination of skin biopsies of a papule lesion showed dense neutrophilic infiltration limited to the subcutaneous tissue. The pustules and papules disappeared completely after treatment with systemic corticosteroids. To our knowledge, only one patient was identified by MEDLINE search of the English‐language literature. Am. J. Hematol. 76:61–65, 2004. © 2004 Wiley‐Liss, Inc.
Thrombotic Thrombocytopenic Purpura Complicating Sjögren's Syndrome
Authors: Alfred D. Steinberg
Journal: JAMA (1971)

Three patients with Sjogren's syndrome developed fever, central nervous system disease, thrombocytopenia, and bleeding. All died within two weeks. Hyaline thrombi were present in arterioles and capillaries post mortem. To our knowledge, this is the first report of an association between thrombotic thrombocytopenic purpura and Sjogren's syndrome.
Silent Ischemia as a Central Problem: Regional Brain Activation Compared in Silent and Painful Myocardial Ischemia
Authors: Stuart D. Rosen
Journal: Annals of Internal Medicine (1996)

Objective: To test whether the silence of painless myocardial ischemia is caused by abnormal handling by the central nervous system of afferent messages from the heart. Design: Nonrandomized study. Setting: A tertiary referral center (postgraduate medical school). Patients: 2 matched groups of nondiabetic patients with coronary artery disease. Group A consisted of nine patients with reproducible stress-induced angina; group B consisted of nine patients with reproducible stress-induced myocardial ischemia but no angina. Interventions: Intravenous placebo infusion and low-dose (5 and 10 µg/kg per minute) and high-dose (20 to 35 µg/kg per minute) dobutamine infusions. Measurements: Positron emission tomography was used to measure regional cerebral blood flow changes as an index of neuronal activation during painful and silent myocardial ischemia induced by intravenous dobutamine. Results: Regional cerebral blood flow changes during myocardial ischemia were compared with those during baseline conditions and during placebo infusion. During myocardial ischemia, regional cerebral blood flow increased bilaterally in the thalami and prefrontal, basal frontal, and ventral cingulate cortices in patients in group A. Both thalami were activated in group B, but cortical activation was limited to the right frontal region. A formal comparison of groups A and B showed significant differences (P < 0.01) in activation of the basal frontal cortex, ventral cingulate cortex, and left temporal pole. In both groups, thalamic regional cerebral blood flow remained increased after the symptoms and signs of ischemia had ceased. Conclusions: Bilateral activation of the thalamus can be shown in both angina and silent ischemia; thus, peripheral nerve dysfunction cannot completely explain silent ischemia. Frontal cortical activation appears to be necessary for the sensation of pain. Abnormal central processing of afferent pain messages from the heart may play a determining role in silent myocardial ischemia.
A CONTRIBUTION TO THE SUBJECTS OF CHRONIC INTERSTITIAL NEPHRITIS AND ARTERITIS IN THE YOUNG, AND FAMILY NEPHRITIS; WITH A NOTE ON CALCIFICATION IN THE LIVER
Authors: N. E. Brill, E. Libman
Journal: The Journal of Experimental Medicine (1899)

Chronic nephritis in children and adolescents is a condition which has been much overlooked.Especially is this true of the chronic interstitial type (contracted kidney).Dickinson was of the opinion that the latter condition was not infrequent in children.Heubner (1), who has lately written a monograph upon this subject, from which many of these introductory remarks are cited, states that of 251 cases of chronic nephritis which he observed in Leipsic, 214 occurred in adults and 37 in children.Later, in Berlin, he saw 28 cases in children, mostly after scarlet fever.Of these 65 cases, there were 3 of parenchymatous nephritis, 4 of contracted kidney and 5 of chronic h~emorrhagic nephritis (Wagner).Of 33 cases of chronic interstitial nephritis observed by Barrels (2), one occurred at the age of 18, one at 19, and two at 20.Of Dickinson's (3) 308 cases, one occurred between 11 and 20 years, and 24 between 21 ancl 30 years.From these figures it is seen that under the age of 20, chronic interstitial nephritis is uncommon, but not so rare as the omission of reference to it in many text-books on children's diseases would indicate.T h e condition is even more frequent than these figures would lead us t(~ infer, as many of the cases are overlooked and treated for anaemia for a long time.This is especially true of the subacute cases of productive nephritis described by Dela~ield (4).Of the interstitial cases, which alone interest us here, Heubner states that there are but thirty on record in which post-mortem examinations were made.Besides these, there are numerous other instances reported in which the patients were not observed until the fatal termination, or where no autopsy was performed.To these cases, Heubner adds four from his * Tra'nsact4ons of the London Path~ogSval Society, 1892, p. 46, cited in part by Delafield (4).
Determining a definite diagnosis of primary immune thrombocytopenia by medical record review
Authors: Deirdra R. Terrell, Laura A. Beebe, Sara K. Vesely, Barbara R. Neas, Jodi B. Segal, James N. George
Journal: American Journal of Hematology (2012)

The objective of this study is to establish a method to identify patients with primary immune thrombocytopenia (ITP) utilizing administrative data from diverse data sources that would be appropriate for epidemiologic studies of ITP, regardless of patients' age and source of health care. Medical records of the Oklahoma University Medical Center, 1995-2004, were reviewed to document the accuracy of the administrative code ICD-9-CM 287.3 for identifying children and adults with ITP, using novel, explicit levels of evidence to identify patients with a definite diagnosis. The proportion of patients diagnosed by hematologists compared to non-hematologists and the proportion of patients diagnosed as outpatients compared to inpatients were determined. For children, age <16 years, 323 outpatient medical records were reviewed; 225 adult outpatient medical records were reviewed. The positive predictive value for the administrative code for identifying patients with a definite diagnosis of ITP by a hematologist was 0.72 in children and 0.69 in adults. In 98% of children and 92% of adults seen as outpatients, the definite diagnosis of ITP was established by a hematologist. One hundred eighteen child and 141 adult inpatient medical records were reviewed. In 95% of children and 83% of adults, the definite diagnosis of ITP by a hematologist was established as an outpatient. This study confirmed the previously reported positive predictive value for the administrative code for identifying patients with ITP. Additionally, it was determined that analysis of hematologists' outpatient administrative codes identified most children and adults with ITP. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.
Treatment of Anogenital Papillomavirus Infections with an Acyclic Nucleoside Phosphonate Analogue
Authors: R. Snoeck, M. Van Ranst, G. Andrei, E. De Clercq, S. De Wit, M. Poncin, N. Clumeck
Journal: New England Journal of Medicine (1995)

To the Editor: (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is an acyclic nucleoside phosphonate analogue with broad-spectrum antiviral activity against DNA viruses, including herpesviruses (herpes simplex virus, varicella–zoster virus, cytomegalovirus, and Epstein–Barr virus), adenoviruses, poxviruses, and papillomaviruses.1,2 We recently showed that local injections of HPMPC into a life-threatening squamous papilloma of the hypopharynx–esophagus eradicated the tumor.2 Two years later, the patient was still free of disease. We report the use of HPMPC in three patients with AIDS and severe, relapsing anogenital human papillomavirus lesions. A 44-year-old homosexual man had been unsuccessfully treated for recurrent penile human papillomavirus lesions since December 1993 with curettage . . .
Dobutamine Modulated Tc-99m MIBI Scintigraphy in Secondary Hyperparathyroidism in Uremic Patients
Authors: Adriana Quagliata, Juan J. López, Patricia Guissoli, Juan P. Gambini, Juan C. Hermida, Omar Alonso
Journal: Clinical Nuclear Medicine (2007)

The aim of this study was to determine if low-dose dobutamine infusion can enhance Tc-99m methoxy isobutyl isonitrile (MIBI) uptake of hyperfunctioning parathyroid glands of patients with secondary hyperparathyroidism (SHP). We studied 24 patients with chronic renal failure and SHP. Median age of the sample was 47.5 years. A single-tracer, double-phase technique was performed, acquiring planar images of the neck and thorax after the injection of 740 to 1110 MBq (20–30 mCi) of Tc-99m MIBI. After 2 to 7 days, the study was repeated after the infusion of low-dose dobutamine of 2.0 μg · kg−1 · min−1 for 60 minutes. The scan was considered positive for hyperfunctioning parathyroid tissue when an area of increased uptake that persisted on late imaging was found. Parathyroid-to-thyroid count rates (PT/T) were calculated for each abnormal focus. Hyperplasic parathyroid tissue was confirmed in 12 of 24 patients who underwent neck surgery whereas the remaining group had persistent or worsening disease, verified by clinical follow-up between 6 and 25 months after the nuclear studies (median: 12 months). An MIBI baseline study was positive in 21 of 24 patients (87%), whereas the dobutamine study was positive in all patients. Thirty-five abnormal foci were seen on baseline MIBI studies and 43 on dobutamine scans (1.46 ± 1.02 vs. 1.79 ± 0.88, mean ± SD, respectively, P = 0.043). Dobutamine PT/T ratios were significantly higher than those from the baseline study (1.49 ± 0.30 vs. 1.38 ± 0.28, mean ± SD, respectively, P = 0.0002, n = 43). We concluded that low-dose dobutamine Tc-99m MIBI scintigraphy has the potential of enhancing tracer uptake and retention in patients with SHP.
Review: Low-dose CT screening reduces lung cancer and mortality in current or former smokers
Authors: Christopher Lathan, David A. Frank
Journal: Annals of Internal Medicine (2013)

Source Citation Humphrey LL, Deffebach M, Pappas M, et al. Screening for lung cancer with low-dose computed tomography: a systematic review to update the US Preventive Services Task Force recommendation. Ann Intern Med. 2013;159:411-20. 23897166
ASSOCIATION OF FIBROBLAST GROWTH FACTOR (FGF)-23 LEVELS WITH RISK OF CARDIOVASCULAR EVENTS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE
Authors: Jacob A. Udell, Thomas O&apos;Donnell, David Morrow, Petr Jarolim, Torbjorn Omland, Sarah Sloan, Marc Pfeffer, Eugene Braunwald, Marc Sabatine
Journal: Journal of the American College of Cardiology (2012)
Milburn refuses to renegotiate consultants' contract
Authors: Z. Kmietowicz
Journal: BMJ (2002)

Doctors' leaders are urging the health secretary, Alan Milburn, to enterinto fresh talks over the proposed new contract for consultants amid fearsthat it could be implemented in parts of the United Kingdom despite the factthat most doctors rejected it.

Nearly two thirds of the United Kingdom's consultants and 84% of specialist registrars voted against the contract. However, Mr Milburn is believed to be preparing an alternative deal for consultants …