STUDIES RELATING VITAMIN C DEFICIENCY TO RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS; EXPERIMENTAL, CLINICAL AND GENERAL CONSIDERATIONS*
Authors: JAMES F. RINEHART
Journal: Annals of Internal Medicine (1935)

Article1 December 1935STUDIES RELATING VITAMIN C DEFICIENCY TO RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS; EXPERIMENTAL, CLINICAL AND GENERAL CONSIDERATIONSII. RHEUMATOID (ATROPHIC) ARTHRITISJAMES F. RINEHART, M.D.JAMES F. RINEHART, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-6-671 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA border-land between rheumatic fever and rheumatoid arthritis has long been recognized. Particularly in young adults clinical distinction may prove difficult or one may find an apparently typical rheumatic fever with carditis progress into a characteristic rheumatoid arthritis. Klinge and Grzimek1find that although acute and subacute rheumatic fever and chronic polyarthritis are usually easily differentiated, both disease pictures are so closely bound together in the arthritic and general pathology that a "rheumatic" basis may be assigned to both. Dawson2has lent further support to the concept of a relationship of the two diseases in showing that the early pathological...References1. KLINGEGRZIMEK FN: Das Gewebsbild des fieberhaften Rheumatismus. VI. Mitteilung. Der chronische Gelenkrheumatismus (Infektarthritis, Polyarthritis lenta) und über "rheumatische Stigmata," Virchow's Arch. f. path. Anat., 1932, ccxxciv, 646-712. CrossrefGoogle Scholar2. DAWSON MH: A comparative study of subcutaneous nodules in rheumatic fever and rheumatoid arthritis, Jr. Exper. Med., 1933, lvii, 845-858. CrossrefGoogle Scholar3. 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Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Read at the Philadelphia meeting of the American College of Physicians, May 1, 1935.This work has been made possible by research funds granted from the Christine Breon Fund for Medical Research.The first part of Dr. Rinehart's article appeared in the preceding number of the ANNALS.†The basic diet used is as follows:Per centGround rolled oats and bran—equal parts by volume .................... 56Powdered skimmed milk (baked at 110° for 2 hours) .................. 30Butter fat ........................................................... 10Sodium chloride ..................................................... 0.5Osborne-Mendel salt mixture ......................................... 1.0Dried yeast ......................................................... 1.5Cod-liver oil (standardized) .......................................... 1.0Care is used in securing a thorough mixture of the above ingredients. Guinea pigs eat this diet well and, with adequate vitamin C supplement, grow and thrive. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByStreptococcal PharyngitisStreptococcal PharyngitisMuscular changes in the guinea pig caused by chronic ascorbic acid deficiencyDie Pathologie der Avitaminosen und HypervitaminosenThe Experimental Production of Arthritis: A ReviewAetiology and pathogenesis of rheumatoid arthritisVitamine und VitaminkrankheitenPLASMA CELLULAR REACTION AND RETICULOSIS OF THE SPLEEN IN EXPERIMENTAL SCURVY IN RELATION TO THE ELECTROPHORETIC PATTERN OF THE SERUM PROTEINSSkeletal Muscle Changes in Scurvy with a Note on the Mechanism of the Attachment of Myofibrils to TendonThe Effect of Vitamin Deficiencies on Adrenocortical FunctionTHE DETECTION OF SUBCLINICAL SCURVY OR VITAMIN C DEFICIENCY*JAMES F. RINEHART, M.D., LOUIS D. GREENBERG, PH.D.L A Survey of the Relation between Nutrition and the EarTreatment with Vitamin C (Cevitamic Acid—Ascorbic Acid)Observations on polyarthritis and on experimentalErysipelothrix infection of swineIII Chronic Progressive Deafness with Special Reference to Estrogenic Substances a Further ContributionTHE INFLUENCE OF VITAMIN DEFICIENCIES ON OTHER DISEASES*JOHN B. YOUMANS, M.D., F.A.C.P.CEVITAMIC ACID (ASCORBIC ACID; CRYSTALLINE VITAMIN C); A CRITICAL ANALYSIS OF ITS USE IN CLINICAL MEDICINE*IRVING S. WRIGHT, A.B., M.D., F.A.C.P.Fundamental factors in bodily growth and their relation to the orthodontic problemLXXIV. Chronic Progressive Deafness from a Nutritional Standpoint: A Preliminary ReportThe Arthritis ProblemVITAMIN C AND INFECTION EXCRETION OF VITAMIN C IN PULMONARY TUBERCULOSIS AND IN RHEUMATOID ARTHRITIS 1 December 1935Volume 9, Issue 6Page: 671-689KeywordsDietOilsResearch fundingResearch grantsRheumatic feverRheumatoid arthritisSaltsSodium chlorideVitamin CYoung adults Issue Published: 1 December 1935 PDF DownloadLoading ...