tbuckley/cabot-search huggingface dataset:
Abstract 3141: Analysis of the endocrine treatment predictive protein HOXB13 in premenopausal breast cancer
Authors: Piiha-Lotta Jerevall, Agneta Jansson, Ann-Christine Källström, Göran Landberg, Mårten Fernö, Olle Stål
Journal: Cancer Research (2011)

Abstract Homeobox B13 (HOXB13), part of the two-gene expression index H:I, has proven its capacity as a predictive factor of tamoxifen benefit in breast cancer. We have previously shown that in addition to mRNA expression, the protein shows predictive value in postmenopausal patients. High levels were associated with decreased tamoxifen (Tam) benefit and may indicate endocrine resistance, whereas Tam-treated patients with low expression had a longer recurrence-free survival. Here, we have analyzed HOXB13 protein expression in premenopausal breast cancer patients. We quantified the levels of HOXB13 with immunohistochemistry in tumor samples from 487 patients sampled in duplicates on tissue micro arrays. Patients were diagnosed with stage II invasive breast cancer and randomized to Tam or no endocrine treatment. HOXB13 protein analysis was successful in 367 patients. Data were correlated with clinicopathological variables. Using Kaplan Meier analysis to investigate Tam benefit in patients with tumors expressing estrogen receptor (ER) α, progesterone receptor, or both, patients with high HOXB13 levels unexpectedly benefited from Tam (hazard ratio for recurrences 0.43, 95% CI 0.28-1.01, p=0.053). Corresponding numbers for a lower expression were 0.69 (95% CI 0.44-1.07, p=0.1). For further analysis, we stratified the patients based on tumor ERβ status, which seemed to be an indicator of the performance of HOXB13 as a treatment predictive factor. Interaction between HOXB13 expression and benefit from Tam in the ERβ- group was close to significant (p=0.06), and corresponding p-value for the ERβ+ patients was 0.11. In conclusion, endocrine treatment prediction for premenopausal breast cancer patients using the protein levels of HOXB13 does not seem to be as straight forward as in postmenopausal patients. Based on our results, ERβ may be an additional determinant in predicting benefit from Tam-treatment using HOXB13 protein expression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3141. doi:10.1158/1538-7445.AM2011-3141
The effects of topically applied hexyl nicotinate lotion on the cutaneous blood flow in patients with Raynaud's phenomenon
Authors: C.B. BUNKER, S. LANIGAN, M.H.A. RUSTIN, PAULINE M. DOWD
Journal: British Journal of Dermatology (1988)

The effect of the epicutaneous application of 0.1% and 1.0% hexyl nicotinate lotion on upper limb skin blood flow was investigated in 25 patients with Raynaud's phenomenon (RP) and five healthy volunteers. Assessments were made using laser Doppler velocimetry. The 0.1% lotion induced an increase in cutaneous blood flow in both controls and patients when applied at different sites on the upper limb. Increased cutaneous blood flow occurred more often when the lotion was applied to the forearm than to the fingers. A greater increase in blood flow and an increased percentage of positive responses was elicited with the 1.0% hexyl nicotinate lotion. Hexyl nicotinate lotion may be of value in the topical treatment of RP.
Infection-Control Measures Reduce Transmission of Vancomycin-Resistant Enterococci in an Endemic Setting
Authors: Marisa A. Montecalvo, William R. Jarvis, Jane Uman, David K. Shay, Coleen Petrullo, Karen Rodney, Cheryl Gedris, Harold W. Horowitz, Gary P. Wormser
Journal: Annals of Internal Medicine (1999)

Background: Vancomycin-resistant enterococci (VRE) are nosocomial pathogens in many U. S. hospitals. Objective: To determine whether enhanced infection-control strategies reduce transmission of VRE in an endemic setting. Design: Prospective cohort study. Setting: Adult oncology inpatient unit. Patients: 259 patients evaluated during use of enhanced infection-control strategies and 184 patients evaluated during use of standard infection-control practices. Interventions: Patient surveillance cultures were taken, patients were assigned to geographic cohorts, nurses were assigned to patient cohorts, gowns and gloves were worn on room entry, compliance with infection-control procedures was monitored, patients were educated about VRE transmission, patients taking antimicrobial agents were evaluated by an infectious disease specialist, and environmental surveillance was performed. Measurements: VRE infection rates, VRE colonization rates, and changes in antimicrobial use. Results: During use of enhanced infection-control strategies, incidence of VRE bloodstream infections decreased significantly (0.45 patients per 1000 patient-days compared with 2.1 patients per 1000 patient-days; relative rate ratio, 0.22 [95% CI, 0.05 to 0.92]; P = 0.04), as did VRE colonization (10.3 patients per 1000 patient-days compared with 20.7 patients per 1000 patient-days; relative rate ratio, 0.5 [CI, 0.33 to 0.75]; P < 0.001). Use of all antimicrobial agents except clindamycin and amikacin was significantly reduced. Conclusion: Enhanced infection-control strategies reduced VRE transmission in an oncology unit in which VRE were endemic.
Postsynthetic deamidation of hemoglobin Providence (beta 82 Lys replaced by Asn, Asp) and its effect on oxygen transport.
Authors: S Charache, J Fox, P McCurdy, H Kazazian, R Winslow, P Hathaway, R van Beneden, M Jessop
Journal: Journal of Clinical Investigation (1977)

Carriers of hemoglobin Providence have three types of beta chain in their hemolysates. The two abnormal chains have asparagine (Providence N, Prov N) or aspartic acid (Providence D) at position beta 82, instead of lysine. In vitro, only two beta chains are synthesized by reticulocytes of carriers, betaA and betaProv N. In vivo studies showed that the specific activity of Providence N was initially 10-fold higher than that of Providence D; the specific activities of the two labeled hemoglobins were approximately equal 5 wk after injection of isotope. Oxygen affinity of carriers' blood was somewhat increased, but they were not polycythemic. The affinity of the purified hemoglobins Providence was decreased. Addition of 2, 3 diphosphoglycerate had little effect on the affinity of either hemoglobin component, and addition of inositol hexaphosphate produced no change in the affinity of Providence D. These studies demonstrate that Providence N is deamidated to Providence D during the life span of the erythrocyte, and suggest this finding may represent only an easily observed prototype of posttranslational modification of proteins in general. Despite and abnormal P50 of the blood, oxygen transport is probably normal in carriers of the abnormal hemoglobins.
Dealing with editorial misconduct
Authors: R E Laube
Journal: BMJ (2005)

Editor—I would like to add another category of editorial responsibilities to the list considered for a code of conduct in Godlee's article1: the relationship with reviewers and authors.

In my experience, editors of even the most prestigious journals exchange emails and phone calls with friends and other associates regarding accepting submissions and “invited” articles and editorials. This is within the rightful purview of their role. The problem arrives when this network (unintentionally) serves to promote a particular group or way of thinking in favour of a competing group or an alternative approach to an issue.

I have experienced situations where acceptance was facilitated by a quick call or message from a supervisor to a friendly editor, where reviewers rejected material that would have beaten their work into press (other reviewers should have been selected), where reviewing was passed on to the graduate assistant rather than done by the professor, and where liberal courtesies have been extended to authors and reviewers because of their positions rather than their contributions.

Academic, clinical, legal, and administrative bodies foist an authoritative role on peer reviewed professional journals. Much of this is driven by the perception that the journals are “impartial.” If a journal wishes to reject this role then the editors should decline loudly. If the editor and publisher wish to capitalise on the presumption of anonymous impartiality, then they should be honourable about it and move beyond the “old mates network” approach to the job.
Candida Endocarditis Treated with 5-Fluorocytosine
Authors: C. O. Record, J. M. Skinner, P. Sleight, D. C. E. Speller
Journal: BMJ (1971)

Three patients with endocarditis due to <i>Candida</i> species were treated with 5-fluorocytosine. One had endocarditis imposed on senile aortic sclerosis and survived and two had infections on prosthetic valves and died. In the latter two patients chemotherapy failed to eradicate the infection and was associated with marrow depression and possibly hepatic necrosis.
Sulphasalazine induced seminal abnormalities in ulcerative colitis: results of mesalazine substitution.
Authors: S A Riley, J Lecarpentier, V Mani, M J Goodman, B K Mandal, L A Turnberg
Journal: Gut (1987)

Seminal abnormalities are commonly found during sulphasalazine treatment. Although these changes appear reversible after drug withdrawal this may result in colitis relapse. Animal studies suggest that 5-aminosalicylic acid, the active component of sulphasalazine, does not impair fertility. Sixteen patients with quiescent ulcerative colitis were studied. Each patient produced three samples of semen at weekly intervals. Of the 48 samples analysed 39.6% showed oligospermia, 41.7% showed an increased number of abnormal forms and 91.7% showed impaired motility. Nine patients substituted enteric coated mesalazine (5-aminosalicylic acid) for sulphasalazine for a minimum period of three months. During this time one patient developed a salmonella associated colitis relapse; the others remained well. Improvement in sperm count (p less than 0.02), motility (p less than 0.001) and morphology (p less than 0.02) occurred in all cases. To date, four successful pregnancies have resulted, three in couples complaining of long term infertility. Treatment with enteric-coated mesalazine allows the recovery of seminal abnormalities induced by sulphasalazine in patients with colitis.
Haemodynamic changes in adrenaline-induced acute massive lung oedema
Authors: C. P. K. CHENG
Journal: Cardiovascular Research (1975)

During the production of adrenaline-induced acute massive lung oedema in the dog, pulmonary arterial, pulmonary venous, systemic arterial, and bronchial arterial blood pressures all increase markedly. Pulmonary arterial and venous blood flows fall steeply after initial transient rises. Systemic arterial blood flow also declines, with or without an initial transient increase. The bronchial arterial blood flow shows an initial fall followed by a rise of late onset. The main determinant for the pathogenesis of adrenaline-induced lung oedema is apparently the enormously increased hydrostatic pressure in the pulmonary vascular bed.
The "Medical Expert Witness"
Authors: Milton Rosenbaum
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The recent, highly publicized Patty Hearst trial brought into focus the sad spectacle of physicians (this time, psychiatrists) taking an adversary position in courts of law. I believe, as do many of my colleagues, that it is high time organized medicine takes a stand on this issue by supporting a resolution that the "expert medical witness" (including the psychiatrist) testify only as "a friend of the court." In the late 1940s, a small group— Charles Aring, MD, Philip Piker, MD, and I—put through a resolution in the Cincinnati Society of Neurology and Psychiatry that no member of the Society would testify in a capital crime case except as "a friend of the court." Although questions have been raised about the constitutionality of such a position, to the best of my knowledge, this resolution is still in effect, and its constitutionality has not been challenged. Testifying as a
Peter Morgan Sutton
Authors: H. Sutton
Journal: BMJ (2014)

Peter Morgan Sutton was the older son of Sir Graham and Lady Doris Sutton. After receiving his education at Bishop Wordsworth School, Salisbury, and Wrekin College, Wellington, he trained in medicine at University College London, where he obtained an honours degree in anatomy, and at University College Hospital Medical School. Sutton specialised in the branch of pathology then known as morbid anatomy—the study of changes in organs and tissues, caused by disease. Successive promotions from Graham Scholar led to his becoming reader at UCH Medical School, and honorary consultant at the hospital. He also spent a year in the US, as a visiting professor in Pittsburgh.

Sutton was a superb diagnostic surgical pathologist and an outstanding teacher: known for his enthusiasm and clarity in formal lectures to medical students, over the microscope and across the autopsy table, always leavened by his impish sense of humour and lack of pomposity. He was an influential and caring mentor to trainee pathologists, quietly but effectively managing their professional development and always approachable and …
P2-064: The impact on survival of high baseline Cyfra 21-1 in non-small-cell-lung cancer (NSCLC) submitted to surgery: a 15-years study including 829 patients (pts). The role of adjuvant and neo-adjuvant chemotherapy
Authors: Pedro Barradas, Maria José Melo, Agostinho Costa, Paula Alves, Margarida Cristóvão
Journal: Journal of Thoracic Oncology (2007)
Human Gene Therapy Trial in Cancer Patients About To Begin
Authors: F. S. Antoine
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Human Gene Therapy Trial in Cancer Patients About To Begin Get access Florence S. Antoine Florence S. Antoine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 24, 19 December 1990, Pages 1877–1878, https://doi.org/10.1093/jnci/82.24.1877 Published: 19 December 1990
Intramedullary Abscess Resulting from Disseminated Cryptococcosis Despite Immune Restoration in a Patient with AIDS
Authors: J. Rambeloarisoa, D. Batisse, J.-B. Thiebaut, J. Mikol, S. Mrejen, M. Karmochkine, M.D. Kazatchkine, L. Weiss, C. Piketty
Journal: Journal of Infection (2002)
Abstract LB-173: Early detection of pancreatic cancer using a new 5-gene classifier
Authors: Manoj Bhasin, Andrea Bullock, Xuesong Gu, Octavian Bucur, Robert Najarian, Jon Cody Haines, Karl Ruping, Rebecca Miksad, Towia Libermann, Roya Khosravi-Far
Journal: Cancer Research (2014)

Abstract Background: Largely due to late diagnosis when curative resection is no longer possible, Pancreatic Adenocarcinoma (PDAC) is a devastating disease marked by a mortality rate nearly equivalent to its incidence rate. While serum CA19-9 is associated with PDAC, it lacks the sensitivity and specificity needed for early and accurate diagnosis. Thus, early diagnosis of PDAC is critical to improving survival for PDAC patients and for accurate PDAC risk stratification. Methods: We have identified key PDAC biomarkers through an optimized meta-analysis strategy of raw data (training sets). From this analysis, the top ranking genes that distinguish PDAC from normal pancreas were selected through statistical significance comparison of the consistency in differential PDAC gene expression across studies. The biomarker panel with the highest sensitivity and specificity in the training sets was chosen for assessment of predictive power in nine independent validation datasets. For a subset of genes in the panel, immunohistochemistry (IHC) analysis was performed in human PDAC and pancreatitis to validate our panel. Results and Conclusions: We have identified a 5-gene classifier panel with specificity of 88.9% and sensitivity of 100% with an overall accuracy of 93.3% and AUC of 0.94 for discriminating PDAC from non-malignant (normal or pancreatitis) tissue. IHC analysis of two of the proteins confirmed enhanced expression in PDAC cells. Cell-based experiments demonstrated that both proteins enhance migration and invasion of PDAC cells as well as soft agar growth indicating that they may be causative in PDAC. The 5-gene predictor discriminated PDAC from healthy controls, as well as pancreatitis, with highest accuracy in nine independent validation sets. Our identified PDAC panel may facilitate early diagnosis and improve risk-stratification. Citation Format: Manoj Bhasin, Andrea Bullock, Xuesong Gu, Octavian Bucur, Robert Najarian, Jon Cody Haines, Karl Ruping, Rebecca Miksad, Towia Libermann, Roya Khosravi-Far. Early detection of pancreatic cancer using a new 5-gene classifier. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-173. doi:10.1158/1538-7445.AM2014-LB-173
Hyperkinesia of non-infarcted myocardium with isoproterenol infusion can cause ST-segment elevation in previous myocardial imfarction
Authors: Toshio Miyazaki, Yutaka Hirane, Tadahiko Yamamoto, Keizo Yamashita, Makoto Ohno, Hitoshi Kawabata, Kinji Ishikawa, Ryo Katori
Journal: Journal of the American College of Cardiology (1990)
Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial Hypercholesterolemia
Authors: Hiroshi Mabuchi, Toshihiro Haba, Ryzo Tatami, Susumu Miyamoto, Yasuyuki Sakai, Takanobu Wakasugi, Akira Watanabe, Junji Koizumi, Ryoyu Takeda
Journal: New England Journal of Medicine (1981)

We studied the effects of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, on serum levels of lipoproteins and ubiquinone-10 in seven heterozygous patients with familial hypercholesterolemia. ML-236B was given at doses of 30 to 60 mg per day for 24 weeks. Serum cholesterol decreased from 390±9 to 303±8 mg per deciliter (10.1 ±0.2 to 7.88±0.2 mmol per liter, mean ±S.E.M.; P<0.001), and serum triglyceride decreased from 137±18 to 87±9 mg per deciliter (1.55±0.20 to 0.98±0.1 mmol per liter; P<0.05). Intermediate-density-lipoprotein (IDL) cholesterol, IDL triglyceride, low-density-lipoprotein (LDL) cholesterol, and LDL triglyceride decreased significantly (P<0.01, P<0.02, P<0.001, and P<0.001, respectively). However, there were no significant changes in very-low-density-lipoprotein (VLDL) cholesterol and triglyceride or high-density-lipoprotein (HDL) cholesterol. Serum ubiquinone-10 levels did not change, and LDL levels of ubiquinone-10 decreased by 50 per cent, from 0.39±0.07 to 0.20±0.01 μg per milliliter (P<0.05). No adverse effects were observed. We conclude that ML-236B is effective in lowering serum cholesterol without lowering serum ubiquinone-10 in heterozygous patients with familial hypercholesterolemia. (N Engl J Med. 1981; 305:478–82.)
NEURAL SELECTION AND CONTROL OF VISUALLY GUIDED EYE MOVEMENTS
Authors: Jeffrey D. Schall, Kirk G. Thompson
Journal: Annual Review of Neuroscience (1999)

▪ Abstract We review neural correlates of perceptual and motor decisions, examining whether the time they occupy explains the duration and variability of behavioral reaction times. The location of a salient target is identified through a spatiotemporal evolution of visually evoked activation throughout the visual system. Selection of the target leads to stochastic growth of movement-related activity toward a fixed threshold to generate the gaze shift. For a given image, the neural concomitants of perceptual processing occupy a relatively constant interval so that stochastic variability in response generation introduces additional variability in reaction times.
Methemoglobinemia Provoked by Malarial Chemoprophylaxis in Vietnam
Authors: Richard J. Cohen, John R. Sachs, Donna J. Wicker, Marcel E. Conrad
Journal: New England Journal of Medicine (1968)

Six American soldiers were evacuated from Vietnam because they became cyanotic while taking antimalarial drugs. Investigations of these and two additional subjects revealed a markedly decreased concentration of NADH methemoglobin reductase in red blood cells and a decreased capacity of erythrocytes to reduce methemoglobin to hemoglobin in vitro. Two of the subjects were identical twins; a study of 19 members of their family revealed three additional enzyme-deficient members and 10 additional relatives with low enzyme values. Chloroquine, primaquine and diaminodiphenylsulfone were each shown to provoke methemoglobinemia in enzyme-deficient subjects in doses that have no effect on normal persons. The cyanosis produced by antimalarial drugs permitted clinical recognition of a usually undetected enzymatic defect of the erythrocyte. Heterozygotes with a deficiency of NADH methemoglobin reductase may be more numerous than has been realized, and the continued use of antimalarial drugs in Vietnam may provide new information about the true prevalence of this defect.
Platelet-associated anti–GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb
Authors: Satoru Kosugi, Yoshiaki Tomiyama, Shigenori Honda, Hisashi Kato, Teruo Kiyoi, Hirokazu Kashiwagi, Yoshiyuki Kurata, Yuji Matsuzawa
Journal: Blood (2001)
Short and long term prognosis of acute myocardial infarction since introduction of thrombolysis.
Authors: R Stevenson, K Ranjadayalan, P Wilkinson, R Roberts, A D Timmis
Journal: BMJ (1993)

To record prognosis and determinants of outcome in patients with acute myocardial infarction since thrombolysis was introduced.Observational study.London district general hospital.608 consecutive patients admitted to the coronary care unit with acute myocardial infarction between 1 January 1988 and 31 December 1991.All cause mortality, non-fatal ischaemic events (myocardial infarction, unstable angina), and revascularisation.Of the 608 patients, 89 (14.6%) died in hospital. 507 [corrected] patients were followed up after discharge from hospital. Mortality (95% confidence interval) at 30 days, one year, and three years was 16.0% (13.4% to 19.2%), 21.7% (18.6% to 25.2%), and 29.4% (25.3% to 33.9%) respectively. Event free survival (survival without a non-fatal ischaemic event) was 80.4% (77.0% to 83.4%) at 30 days, 66.8% (62.8% to 70.5%) at one year, and 56.1% (51.3% to 60.6%) at three years. Survival in patients treated with thrombolysis was considerably higher than in those not given thrombolysis (three year survival: 76.7% v 54.3%), although the incidence of non-fatal ischaemic events was the same in the two groups. Multivariate determinants of six month survival were left ventricular failure, treatment with thrombolysis and aspirin, smoking history, bundle branch block, and age. For patients who survived six months, age was the only factor related to long term survival.Although patients treated by thrombolysis had a relatively good prognosis, long term mortality and the incidence of non-fatal recurrent ischaemic events remained high. Effective strategies for the identification and treatment of high risk patients need to be reassessed.
Hyperbaric oxygenation in paralytic ileus
Authors: D. Perrins
Journal: BMJ (1977)

bleeding tendency cannot be explained on the basis of a lowered VWFR.The disproportionate increase in VIIIC compared with VIIIA and VWFR may represent a non-specific effect (sic) analogous to similar results seen after exercise.5Nevertheless, in four patients the ratio VIIIA:VWFR was greater than 15, suggesting that the functional capacity of the factor VIII molecule (as assessed by ristocetin cofactor activity) may be impaired in some cases of renal failure.
Expression of BMPRIA on human thymic NK cell precursors: role of BMP signaling in intrathymic NK cell development
Authors: Laura Hidalgo, Víctor G. Martínez, Jaris Valencia, Carmen Hernández-López, Miriam N. Vázquez, José R. Nuñez, Agustín G. Zapata, Rosa Sacedón, Alberto Varas, Angeles Vicente
Journal: Blood (2011)