Liver Transplantation and Hepatitis B
Authors: John J. Poterucha
Journal: Annals of Internal Medicine (1997)

Editorials15 May 1997Liver Transplantation and Hepatitis BJohn J. Poterucha, MD and Russell H. Wiesner, MDJohn J. Poterucha, MDMayo Clinic, Rochester, MN 55905Search for more papers by this author and Russell H. Wiesner, MDMayo Clinic, Rochester, MN 55905Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the United States, 5000 persons die each year of complications of hepatitis B virus (HBV) infection. Liver transplantation prolongs life and improves quality of life for patients with many types of chronic liver disease. It has also been used in patients with hepatitis B, many of whom are young and are otherwise good candidates for transplantation. Unfortunately, the early results of transplantation for patients with chronic hepatitis B were discouraging [1]. Survival was poor, and HBV reinfection of the liver graft often resulted in a rapidly progressive course of disease. In contrast, patients who underwent transplantation for hepatitis C ...References1. Todo S, Demetris AJ, Van Thiel D, Teperman L, Fung JJ, Starzl TE. Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease. Hepatology. 1991; 13:619-26. Google Scholar2. Lake JR. Changing indications for liver transplantation. Gastroenterol Clin North Am. 1993; 22:213-29. Google Scholar3. Medicare program: criteria for Medicare coverage of adult liver transplants-HCFA. Final notice. Fed Regist. 1991; 56:15006-18. Google Scholar4. Belle SH, Beringer KC, Detre KM. An update on liver transplantation in the U.S.: recipient characteristics and outcome. In: Terasaki-Cecha, ed. Clinical Transplants. Los Angeles; UCLA Tissue Typing Laboratory; 1995:1-15. Google Scholar5. O'Grady JG, Smith HM, Davies SE, Daniels HM, Donaldson PT, Tan KC, et al. Hepatitis B virus reinfection after orthotopic liver transplantation. Serological and clinical implications. J Hepatol. 1992; 14:104-11. Google Scholar6. Davies SE, Portmann BC, O'Grady JG, Aldis PM, Chaggar K, Alexander GJ, et al. Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis. Hepatology. 1991; 13:150-7. Google Scholar7. Luketic VA, Shiffman ML, McCall JB, Posner MP, Mills AS, Carithers RL Jr. Primary hepatocellular carcinoma after orthotopic liver transplantation for chronic hepatitis B infection. Ann Intern Med. 1991; 114:212-3. Google Scholar8. Marsman WA, Wiesner RH, Batts KP, Poterucha JJ, Porayko MK, Niesters HG, et al. Fulminant hepatitis B: recurrence after liver transplantation in two patients also infected with hepatitis delta virus. Hepatology. 1997; 25:434-8. Google Scholar9. Samuel D, Muller R, Alexander G, Fassati L, Ducot B, Benhamou JP, et al. Liver transplantation in European patients with the hepatitis B surface antigen. N Engl J Med. 1993; 329:1842-7. Google Scholar10. Marcellin P, Samuel D, Areias J, Loriot MA, Arulnaden JL, Gigou M, et al. Pretransplantation interferon treatment and recurrence of hepatitis B virus infection after liver transplantation for hepatitis B-related end-stage liver disease. Hepatology. 1994; 19:6-12. Google Scholar11. Dienstag JL, Perrillo RP, Schiff ER, Bartholomew M, Vicary C, Rubin M. A preliminary trial of lamivudine for chronic hepatitis B infection. N Engl J Med. 1995; 333:1657-61. Google Scholar12. McGory RW, Ishitani MB, Oliverira WM, Stevenson WC, McCullough CS, Dickson RC, et al. Improved outcome of orthotopic liver transplantation for chronic hepatitis B cirrhosis with aggressive passive immunization. Transplantation. 1996; 61:1358-64. Google Scholar13. Lake JR. Should liver transplantation be performed for patients with chronic hepatitis B7 Liver Transplantation and Surgery. 1995; 1:260-5. Google Scholar14. Lanford RE, Michaels MG, Chavez D, Brasky K, Fung J, Starzl TE. Persistence of extrahepatic hepatitis B virus DNA in the absence of hepatic replication in patients with baboon liver transplants. J Med Virol. 1995; 46:207-11. Google Scholar15. Gish RG, Lau JY, Brooks L, Fang JW, Steady SL, Imperial JC, et al. Ganciclovir treatment of hepatitis B virus infection in liver transplant recipients. Hepatology. 1996; 23:1-7. Google Scholar16. Kruger M, Tillmann HL, Trautwein C, Oldhafer K, Boker KH, Pichlmayr R, et al. Famciclovir treatment of hepatitis B recurrence after orthotopic liver transplantation-a pilot study [Abstract]. Hepatology. 1995; 22:219A. Google Scholar17. Bartholomew MM, Jansen RW, Jeffers LJ, Reddy KR, Johnson LC, Bunzendahl H, et al. Hepatitis B virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. Lancet. 1997; 349:20-2. Google Scholar18. Terrault NA, Holland CC, Ferrell L, Hahn JA, Lake JR, Roberts JP, et al. Interferon alfa for recurrent hepatitis B infection after liver transplantation. Liver Transplantation and Surgery. 1996; 2:132-8. Google Scholar19. Dousset B, Conti F, Houssin D, Calmus Y. Acute vanishing bile duct syndrome after interferon therapy for recurrent HCV infection in liver-transplant recipients [Letter]. N Engl J Med. 1994; 330:1160-1. Google Scholar Author, Article, and Disclosure InformationAuthors: John J. Poterucha, MD; Russell H. Wiesner, MDAffiliations: Mayo Clinic, Rochester, MN 55905Corresponding Author: John J. Poterucha, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.Current Author Addresses: Drs. Poterucha and Wiesner: Mayo Clinic, 200 First Street SW, Rochester, MN 55905. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLamivudine or adefovir dipivoxil alone or combined with immunoglobulin for preventing hepatitis B recurrence after liver transplantationManagement of hepatitis virus infectionsSustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patientsIntramuscular hepatitis B immunoglobulin (HBIG) and nucleosides for prevention of recurrent hepatitis B following liver transplantation: comparison with other HBIG regimensHépatites viralesTransplantation and viral hepatitis: major progressLamivudine or adefovir dipivoxil for preventing hepatitis B recurrence after liver transplantationA treatment algorithm for the management of chronic hepatitis B virus infection in the United StatesExperience with lamivudine therapy for hepatitis B virus infection before and after liver transplantation, and review of the literatureRecent Advances in Liver TransplantationNonimmune Mechanisms of Injury in Renal TransplantationMedical Aspects of Liver TransplantationIntramuscular hepatitis B immune globulin combined with lamivudine for prophylaxis against hepatitis B recurrence after liver transplantationMulticenter study of lamivudine therapy for hepatitis B after liver transplantationInfection in solid organ transplantationViral infections in organ transplantationInfection in Organ-Transplant Recipients 15 May 1997Volume 126, Issue 10Page: 805-807KeywordsChronic hepatitis BDNAFood and Drug AdministrationHepatitis AHepatitis BInfectious hepatitisLiver diseasesLiver transplantationTransplantationViral replication ePublished: 15 August 2000 Issue Published: 15 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. 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