tbuckley/cabot-search huggingface dataset:
Managing radical surgery: notes from the patient's viewpoint.
Authors: M P Kelly
Journal: Gut (1987)

Based on a diary which was kept while preparing for and undergoing pan-proctocolectomy, the paper describes the process of coming to terms with an ileostomy. A number of stages in the process are identified: anticipation, reorientation, trauma, maintenance of selfimage and accommodation. The social-psychological strategies for coping with the process are elaborated.
The Park Nicollet Experience in Establishing a Hospitalist System
Authors: Richard B. Freese
Journal: Annals of Internal Medicine (1999)

A hospitalist system was developed at Park Nicollet Clinic in 1993, was implemented in 1994, and remains in existence today. It was established without knowledge of any other similar program in the United States. Internists and family practitioners were given the choice to continue to care for hospitalized patients or to become totally office based. The new system has met with good patient acceptance along with increased physician satisfaction and retention. This paper describes some key aspects of the institution of the system in a multispecialty group that includes both family practitioners and internists.
Duodenal Perforation after Laparoscopic Cholecystectomy
Authors: C. G. Eden, T. G. Williams
Journal: Endoscopy (1992)

A case is reported of duodenal perforation complicating laparoscopic cholecystectomy performed by laser dissection. The importance of investigating a patient with persistent shoulder-tip pain following this technique to exclude a subphrenic abscess is emphasised.
Investigation and management of persistent dry cough
Authors: G. SIMPSON;, L. P A MCGARVEY, L. G HEANEY, J. MACMAHON
Journal: Thorax (1999)

Intrathoracic extramedullary haematopoiesis (EMH) is a rare entity that is usually asymptomatic.A 44 year old man with alpha-thalassaemia is described who developed dyspnoea and massive left sided haemothorax.The haemoglobin disorder was established by Hgb H staining and haemoglobin electrophoretic studies.The DNA analysis revealed it to be a case of double heterozygous terminal codon mutation with the genotype CS / T .Computed tomographic scanning and magnetic resonance imaging of the thorax showed multiple paravertebral masses which were found by thoracoscopic biopsy to be extramedullary haematopoiesis.Although no additional sclerosing pleurodesis or low dose radiation therapy was given, the lung expanded well and there has been no recurrence of haemothorax to date.
Myocardial consequences of coronary artery bypass graft surgery. The paradox of necrosis in areas of revascularization.
Authors: B H Bulkely, G M Hutchins
Journal: Circulation (1977)

Myocardial infarction after coronary artery bypass graft (CABG) surgery has been described clinically in up to 30% of patients but there is little morphologic information about the character and pathogenesis of the myocardial injury. We studied myocardium in the distribution of bypassed and nonbypassed coronary arteries for the presence of contraction band necrosis as compared to coagulation necrosis, in 58 autopsied patients who died less than 1 month after surgery. Operation related necrosis consisting of focal subendocardial contraction band necrosis was present to some degree in 48 (83%) patients. Regional transmural necrosis was present in 22 (38%) patients and was of two types. Contraction band necrosis occurred in 18 patients and was in the distribution of a patent bypassed coronary artery in 15 of them. Coagulation necrosis was found in four patients, and in each was in the distribution of a new graft-releated coronary artery occlusion. The results suggest that coronary artery reflow through widely patent grafts following the period of operative nonperfusion, rather than graft or intrinsic coronary artery occlusion, accounts for the majority of operation-related myocardial "infarcts" associated with CABG surgery. Thus, prevention of intraoperative myocardial injury must also focus on characteristics of the phase of myocardial reperfusion.
Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors
Authors: Franklin L. Chen, Wenle Xia, Neil L. Spector
Journal: Clinical Cancer Research (2008)

Abstract Breast cancers overexpressing the ErbB2 (HER2) receptor tyrosine kinase oncogene are treated with targeted therapies such as trastuzumab (Herceptin), an anti-ErbB2 antibody, and lapatinib (GW572016/Tykerb), a selective small molecule inhibitor of ErbB2 and epidermal growth factor receptor tyrosine kinases that was recently approved for ErbB2+ breast cancers that progressed on trastuzumab-based therapy. The efficacy of lapatinib as a monotherapy or in combination with chemotherapy, however, is limited by the development of therapeutic resistance that typically occurs within 12 months of starting therapy. In contrast to small molecule inhibitors targeting other receptor tyrosine kinases where resistance has been attributed to mutations within the targeted receptor, ErbB2 mutations have not been commonly found in breast tumors. Instead, acquired resistance to lapatinib seems to be mediated by redundant survival pathways that are activated as a consequence of marked inhibition of ErbB2 kinase activity. For example, inhibition of phosphatidylinositol3 kinase-Akt in lapatinib-treated cells leads to derepression of FOXO3A, a transcription factor that up-regulates estrogen receptor (ER) signaling, resulting in a switch in the regulation of survival factors (e.g., survivin) and cell survival from ErbB2 alone to ER and ErbB2 in resistant cells. In this review, we discuss the effects of lapatinib on signaling networks in ErbB2+ breast cancer cells to elucidate potential mechanisms of therapeutic resistance and strategies to overcome or prevent its development.
F-18 FDG PET Visualization of Urinary Leak After Nephrostomy Tube Removal
Authors: Andrei Iagaru, Sherief Gamie, George Segall
Journal: Clinical Nuclear Medicine (2007)

We present multiple coronal views of a whole-body F-18 FDG PET scan. Transmission images were first acquired and were followed by emission images 1 hour after intravenous administration of 14.9 mCi of the radiopharmaceutical. The study was requested for evaluation of a CT-noted left upper lung nodule in a 45-year-old man admitted for nephrostomy tube removal after percutaneous nephrolithotomy. The scan showed mild FDG uptake in the pulmonary nodule. Abnormal distribution of the radiopharmaceutical was noted posterolateral to the right kidney in addition to the physiological renal excretion. Also presented are abdominal CT images revealing the location of the right nephrostomy tube before removal.
927 PROPOFOL ENHANCES ANTIOXIDANT CAPACITY IN A RAT MODEL OF ACUTE LIVER INJURY INDUCED BY PARACETAMOL INTOXICATION
Authors: A.D. Grypioti, M.G. Mykoniatis, C.A. Demopoulos, Z. Daifoti, G. Kostopanagiotou
Journal: Journal of Hepatology (2008)
Indications for therapy in hepatitis B
Authors: Bulent Degertekin, Anna S. F. Lok
Journal: Hepatology (2009)

Increased treatment options that are more efficacious and safe and new knowledge on the natural history of chronic hepatitis B virus (HBV) infection have expanded the indications for therapy in hepatitis B. The question is no longer "Who should be treated?" but "When should treatment be initiated?" Treatment is clearly indicated in patients with life-threatening liver disease (acute liver failure, decompensated cirrhosis, or severe hepatitis flare) and in those with compensated cirrhosis and high levels of serum HBV DNA. For patients with precirrhotic liver disease, treatment indications should be based on clinical, biochemical, or histological evidence of liver disease, such as elevated alanine aminotransferase (ALT) levels, abnormal histology, and high levels of serum HBV DNA. The cutoff for ALT and HBV DNA values are constantly being revised and should be set at a lower level for older patients who may have been infected for a longer period of time. High serum HBV DNA levels persisting for a few decades are associated with increased risk of clinical outcomes, but there is insufficient data to support the initiation of treatment based on high serum HBV DNA alone, particularly in young patients, those with persistently normal ALT levels, and those with a single high HBV DNA level. The decision to initiate treatment at the time of assessment or to defer treatment should take into consideration other factors such as desire to start a family, occupational requirement, family history of hepatocellular carcinoma, access to care and insurance coverage, and commitment to long-term treatment and medication compliance. All patients who are not initiated on treatment should continue to be monitored so treatment can be started if and when the indication arises.
Spain sets up inquiry after use of frozen eggs for in vitro fertilisation
Authors: X. Bosch
Journal: BMJ (2002)

The Spanish health ministry has started an inquiry after the announcement by an infertility institute that it had used frozen eggs to achieve pregnancies. The current law, which dates back to 1988, allows the freezing of embryos but not the freezing of women's eggs.

The Barcelona based Institute of Human Reproduction (Cefer), which in 1979 created the first Spanish sperm bank, claimed last week that four women had become pregnant after in vitro fertilisation of previously frozen eggs.

Dr Simon Marina, the institute's director, told the national press that eggs started to be thawed at the institute last November. …
Abstract 5265: Akt regulates insulin-like growth factor binding protein-3 by modulating its expression in human non-small cell lung cancer cells.
Authors: Quanri Jin, Hye-Young Min, Young Mi Whang, Yeul Hong Kim, Ho-Young Lee
Journal: Cancer Research (2013)

Abstract Since it has been suggested the insulin-like growth factor (IGF)-independent antitumor effect of insulin-like growth factor binding protein-3 (IGFBP-3) in human cancer cells, the mechanism underlying the regulation of IGFBP-3 in the cells has not been fully studied. Therefore, in this study, we investigated the precise role of Akt in the regulation of cellular IGFBP-3 in human lung cancer cells. Inhibition of PI3K/Akt by siRNA transfection targeting Akt or by treatment with an inhibitor (LY294002) enhanced antiproliferative and proapoptotic effects of IGFBP-3 in lung cancer cells. Additional pharmacological (by using a small molecule inhibitor) or genomic (by siRNA-based silencing of PTEN or overexpression of dominant-negative Akt) approaches suggest that Akt regulates the expression and stability of IGFBP-3 protein. Further characterization of the role of Akt in the regulation of IGFBP-3 by introduction of constitutively active form of each Akt subtype indicates that Akt3 destabilized cellular IGFBP-3 and suppressed retinoic acid-induced IGFBP-3 expression in both TSC2-/- MEF and H226B lung cancer cells. Collectively, these data suggest a novel function of Akt, especially Akt3, as a negative regulator of IGFBP-3 and, further, the possible implication of combined treatment targeting IGFBP-3 and Akt in the treatment of lung cancer. Citation Format: Quanri Jin, Hye-Young Min, Young Mi Whang, Yeul Hong Kim, Ho-Young Lee. Akt regulates insulin-like growth factor binding protein-3 by modulating its expression in human non-small cell lung cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5265. doi:10.1158/1538-7445.AM2013-5265
Endothelial colony-forming cells from patients with chronic myeloproliferative disorders lack the disease-specific molecular clonality marker
Authors: Giovanna Piaggio, Vittorio Rosti, Mirko Corselli, Francesca Bertolotti, Gaetano Bergamaschi, Sarah Pozzi, Davide Imperiale, Barbara Chiavarina, Elisa Bonetti, Francesca Novara, Mario Sessarego, Laura Villani, Anna Garuti, Margherita Massa, Riccardo Ghio, Rita Campanelli, Andrea Bacigalupo, Alessandro Pecci, Gianluca Viarengo, Orsetta Zuffardi, Francesco Frassoni, Giovanni Barosi
Journal: Blood (2009)
Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin.
Authors: D. N. Croft, P. H. Wood
Journal: BMJ (1967)

Surgical Sepsis in New Ward --Rountree et al.MEDBORuL 137However, when all these matters are considered it is still the opinion of the surgeons that surgical practice and the care of the patients was greatly superior to that in the old-style ward.Procedures in vascular surgery that had been discontinued because of the high risk of sepsis in the old accommodation were carried out with relatively good results, and there was much less morbidity and bed loss due to sepsis. SummaryIn a new surgical ward built in 1962 1,337 patients were admitted between January 1963 and May 1965, and 988 had operations.The sepsis rate with Staphylococcus aureus in the patients' wounds was 9%, 10% of the men being infected and 7% of the women.This compared favourably with the rate of 14%so found in 1962 in an old open ward.Only 28% of this sepsis was due to multiple antibiotic- resistant "hospital" strains, compared with 56% in the old ward.There was a reduction in the nasal-carrier rate of hospital strains in patients in the new ward.There was also a reduction in the amount of staphylococcal contamination of the air and bedding.Some of the advantages and disadvantages of the design of the new ward as it affected the care of the patients are discussed, This work was supported in part by a grant from the Nationaf Health and Medical Research Council.Our thanks are particularly due to Mrs. Elisabeth Bradshaw for her technical assistance.Miss I. Smyth, ward sister in charge of the old and new ward accommo- dation, has tolerated with invariable good humour and co-operation the many inconveniences which are an integral part of an investi- gation of this type.
Transposition of the Abdominal Viscera and "Nonvisualization of the Gallbladder"
Authors: James E. Kreisle
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 February 1989Transposition of the Abdominal Viscera and "Nonvisualization of the Gallbladder"James E. Kreisle, MDJames E. Kreisle, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-4-327_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Table 2 of the recent article by Marton and Doubilet (1) lists reasons for nonvisualization of the gallbladder by oral cholecystography. To this list I suggest adding the unexpected transposition of the abdominal viscera. I have observed two cases in which this condition was found to be the cause of "nonvisualization." I saw the first case when I was a medical student in 1941 at the Peter Bent Brigham Hospital, and I saw the second case quite recently in a patient of my Austin colleague, Dr. John Marietta.The right-sided presence of a gastric air bubble or...Reference1. MartonDoubilet KP. How to image the gallbladder in suspected cholecystitis. Ann Intern Med. 1988;109:722-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1989Volume 110, Issue 4Page: 327-327KeywordsGallbladder Issue Published: 15 February 1989 PDF DownloadLoading ...
The HYDERABAD COMMISSION: A REJOINDER to Dr. LAUDER BRUNTON
Authors: L. Hill
Journal: BMJ (1898)

rhage from liver tissue after it has been incised or torn is by temporary compression of the blood vessels in the gastro- hepatic omentum, and then ligature of the divided vessels.3. That when the liver is the seat of growths such as I have mentioned a surgeon ought to be prepared to carry out an operation for their removal.4. That the mortality which will result from operations of this kind is not greater than in many of the recognised abdominal operations, such as resection of the intestine.
A Rare Type of Hodgkin's Disease
Authors: Saul A. Rosenberg
Journal: New England Journal of Medicine (1973)

The interest in Hodgkin's disease in recent years has resulted in improved understanding and treatment of the disease. Among the advances have been a greater attention and ability to detect the extent of the disease, substantial improvement in delivering radiotherapy and parallel advances in the use of chemotherapeutic drugs. The contribution of Lukes, Butler and Hicks1 7 years ago in recognizing the clinicopathological entity of nodular sclerosis was most important in enhancing our understanding of the variables in the clinical picture of this fascinating disease. In this issue of the Journal, Lukes and his colleagues have provided another clear . . .
Comparison of cardiovascular response to combined static-dynamic effort, postprandial dynamic effort and dynamic effort alone in patients with chronic ischemic heart disease.
Authors: J Hung, J McKillip, W Savin, S Magder, R Kraus, N Houston, M Goris, W Haskell, R DeBusk
Journal: Circulation (1982)

The cardiovascular responses to combined static-dynamic effort, postprandial dynamic effort and dynamic effort alone were evaluated by upright bicycle ergometry during equilibrium-gated blood pool scintigraphy in 24 men, mean age 59 +/- 8 years, with chronic ischemic heart disease. Combined static-dynamic effort and the postprandial state elicited a peak cardiovascular response similar to that of dynamic effort alone; work load 643 +/- 156 and 638 +/- 161 vs 650 +/- 153 kg-m/min, respectively; heart rate 147 +/- 14 and 145 +/- 14 vs 143 +/- 17 beats/min; systolic pressure 195 +/- 26 and 200 +/- 25 vs 197 +/- 25 mm Hg; and rate-pressure product 286 +/- 48 and 292 +/- 55 vs 282 +/- 52. Heart rate, intraarterial systolic and diastolic pressures, rate-pressure product and ejection fraction were similar for the three test conditions at the onset of ischemia and at peak effort. The prevalence and extent of exercise-induced ischemic left ventricular dysfunction, ST-segment depression, angina pectoris and ventricular ectopic activity were also similar during the three test conditions. Direct and indirect measurements of systolic and diastolic blood pressure were highly correlated. The onset of ischemic ST-segment depression and angina pectoris correlated as strongly with heart rate alone as with the rate-pressure product during all three test conditions. The cardiovascular response to combined static-dynamic effort and to postprandial dynamic effort becomes more similar to that of dynamic effort alone as dynamic effort reaches a symptom limit. If significant ischemic and arrhythmic abnormalities are absent during symptom-limited dynamic exercise testing, they are unlikely to appear during combined static-dynamic or postprandial dynamic effort. This simplifies, the task of formulating guidelines for physical effort in patients with chronic ischemic heart disease, especially in providing "clearance" to perform avocational and vocational tasks involving combined static-dynamic and postprandial dynamic effort.
Priapism Induced by Proton-Pump Inhibitors and Misoprostol
Authors: Joseph M. Alisky
Journal: Annals of Internal Medicine (2003)

Letters7 October 2003Priapism Induced by Proton-Pump Inhibitors and MisoprostolJoseph M. Alisky, MD, PhDJoseph M. Alisky, MD, PhDFrom Marshfield Clinic; Marshfield, WI 54449-5790.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-7-200310070-00027-w2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:To my knowledge, sexual side effects from antiulcer medications have been reported only once in the medical literature, in the case of a 77-year-old man taking omeprazole and isordil who developed painful nocturnal erections lasting up to 36 hours (1). I describe what may be the second documented case of proton-pump inhibitorinduced priapism and the first case of priapism related to misoprostol.A 61-year-old man taking etodolac, atenolol, pravastatin, and aspirin was prescribed esomeprazole, 40 mg/d, to treat gastritis so that he could continue taking etodolac for severe noncardiac chest pain. An uncomfortable nocturnal erection lasting 2 ...References1. Dutertre JP, Soutif D, Jonville AP, Cadenne M, Valat JP, Autret E. Sexual disturbances during omeprazole therapy [Letter]. Lancet. 1991;338:1022. [PMID: 1681330] CrossrefMedlineGoogle Scholar2. Sarioglu Y, Yildirim S, Utkan T, Yildirim MK, Uma S. Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro. Life Sci. 2000;66:1411-21. [PMID: 11210716] CrossrefMedlineGoogle Scholar3. Moreland RB, Kim NN, Nehra A, Parulkar BG, Traish A. Misoprostol induces relaxation of human corpus cavernosum smooth muscle: comparison to prostaglandin E1. Int J Impot Res. 2000;12:107-10. [PMID: 11052637] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Marshfield Clinic; Marshfield, WI 54449-5790. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 October 2003Volume 139, Issue 7Page: W-72KeywordsAdenosine triphosphateAspirinGastritisInfarctionIschemiaProstaglandinRabeprazole ePublished: 7 October 2003 Issue Published: 7 October 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Uncouplers of oxidative phosphorylation.
Authors: H Terada
Journal: Environmental Health Perspectives (1990)

Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase (H(+)-ATPase). Miscellaneous compounds are known to be uncouplers, but weakly acidic uncouplers are representative because they show very potent activities. The most potent uncouplers discovered so far are the hindered phenol SF 6847, and hydrophobic salicylanilide S-13, which are active in vitro at concentrations in the 10 nM range. For induction of uncoupling, an acid dissociable group, bulky hydrophobic moiety and strong electron-withdrawing group are required. Weakly acidic uncouplers are considered to produce uncoupling by their protonophoric action in the H(+)-impermeable mitochondrial membrane. For exerting these effects, the stability of the respective uncoupler anions in the hydrophobic membrane is very important. High stability is achieved by delocalization of the polar ionic charge through uncoupler (chemical)-specific mechanisms. Such an action of weakly acidic uncouplers is characteristic of the highly efficient membrane targeting action of a nonsite-specific type of bioactive compound.
TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors
Authors: Holbrook E. Kohrt, Brit B. Turnbull, Kartoosh Heydari, Judith A. Shizuru, Ginna G. Laport, David B. Miklos, Laura J. Johnston, Sally Arai, Wen-Kai Weng, Richard T. Hoppe, Philip W. Lavori, Karl G. Blume, Robert S. Negrin, Samuel Strober, Robert Lowsky
Journal: Blood (2009)