tbuckley/cabot-search huggingface dataset:
Influenza viruses do their best to thwart next winter's vaccine
Authors: Charles Marwick
Journal: JAMA (1984)

A new variant of one of the two A-type human influenza viruses has emerged. Sufficiently different from the A-type viruses presently circulating in the United States, it is to be incorporated in next winter's influenza vaccine, a Food and Drug Administration advisory committee has decided. At the same time, the outbreak of avian influenza that has decimated flocks of chickens in Pennsylvania and that also has appeared in New Jersey, Maryland, and Virginia is threatening the supply of fertilized eggs on which flu vaccine manufacturers depend for growing the virus. "We don't anticipate being unable to meet our production goals for flu vaccine next year," said Frank Brandon, PhD, of Parke-Davis, Morris Plains, NJ, a division of the Warner-Lambert Company and one of the three US manufacturers of flu vaccine. "However, eggs are in short supply and this is pushing up the price." How this will affect the cost of
"Sicca Complex" in Liver Disease
Authors: P. L. Golding, R. Bown, A. M. S. Mason, E. Taylor
Journal: BMJ (1970)

Sixty-three patients with liver disease were studied for the presence of the components of Sjögren's syndrome. The "sicca complex" (that is, patients without arthritis) was detected in 42% of patients with active chronic hepatitis, 72% with primary biliary cirrhosis, and 38% with cryptogenic cirrhosis. One patient with active chronic hepatitis and one with primary biliary cirrhosis had rheumatoid arthritis. No evidence of Sjögren's syndrome was detected in seven patients with alcoholic cirrhosis. It is suggested that the sicca complex and autoimmune liver disease may be part of a systemic disorder in which immunological mechanisms are concerned in the pathogenesis.
Six months in New Zealand.
Authors: T Gibson
Journal: Annals of the Rheumatic Diseases (1981)

Six months in New ZealandIt was surprisingly easy to arrange an exchange of medical duties with my old colleague from Guy's, Dr Hugh Burry.He came to live in my cramped suburban house with its patch of lawn.I went to dwell in his hillside bungalow near Wellington, surrounded by 12 acres of steep farmland, sheep, chickens, and a bulky steer.For 6 months I learned to perform the sundry tasks associated with rural life
Lower etanercept levels are associated with high disease activity in ankylosing spondylitis patients at 24 weeks of follow-up
Authors: E L Kneepkens, C L M Krieckaert, D van der Kleij, M T Nurmohamed, I E van der Horst-Bruinsma, T Rispens, G J Wolbink
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Previous data have shown that etanercept levels are associated with clinical response in rheumatoid arthritis. However, for ankylosing spondylitis (AS), data regarding this topic are inconclusive. <h3>Objectives</h3> To investigate the relationship between etanercept levels and clinical response in patients with AS. <h3>Methods</h3> Observational prospective cohort study of 162 patients with AS =treated with etanercept, monitored during 24 weeks of treatment. Etanercept trough levels were determined, retrospectively, using an ELISA. Disease activity was measured using AS Disease Activity Score (ASDAS), including C-reactive protein (CRP) and Bath AS Disease Activity index (BASDAI). Active disease was defined as ASDAS≥2.1. Since etanercept is a drug administered at home there might have been some variation in trough level sampling. <h3>Results</h3> At 24 weeks etanercept levels were significantly higher in patients with ASDAS&lt;2.1, (3.8 mg/L; IQR 2.5–5.2) compared with patients with ASDAS≥2.1 (2.3 mg/L; IQR 1.2–3.4; p≤0.001). Generalised estimating equation analysis demonstrated a statistically significant association between etanercept levels and ASDAS, BASDAI, CRP and erythrocyte sedimentation rate (all p&lt;0.001). When patients were categorised into quartiles according to etanercept levels, the lowest quartile (etanercept&lt;1.80 mg/L) comprised 35% of all patients with ASDAS≥2.1 while the highest quartile comprised only 14%. <h3>Conclusions</h3> Disease activity and inflammation are associated with etanercept levels in patients with AS at 24 weeks of treatment. Measuring etanercept levels might help in identifying overtreatment and undertreatment and optimise etanercept therapy in AS.
Vena Caval Filters for the Prevention of Pulmonary Embolism
Authors: William D. Haire
Journal: New England Journal of Medicine (1998)

Interruption of the inferior vena cava to prevent pulmonary thromboembolism has been practiced since the late 1930s. Initially, this treatment strategy involved a major retroperitoneal surgical procedure to ligate or clamp the vena cava and was associated with considerable morbidity.1 Thirty years later the practice was revolutionized by the introduction of filters that could be placed in the lumen of the inferior vena cava by means of venotomy.2 The relative simplicity of placement of these devices increased the number of patients in whom caval interruption was a practical option. Since their introduction, the use of filters has increased almost yearly, . . .
Incidence of bacteraemia following fibreoptic bronchoscopy
Authors: M. Yigla, I. Oren, L Bentur, A Solomonov, N Elias, R Altshuler, A.e Rubin, F Lejbkowicz
Journal: European Respiratory Journal (1999)

Guidelines for antibiotic prophylaxis of infective endocarditis prior to fibreoptic bronchoscopy, are based on only five studies, which showed a bacteraemia rate of &lt;1% among 291 patients studied. T his study was designed to expand the current data regarding the frequency of bacteraemia following fibreoptic bronchoscopy. Aerobic and anaerobic cultures of venous blood and of lavage fluid were drawn from 200 consecutive patients undergoing fibreoptic bronchoscopy without respiratory infection or antibiotic treatment prior to the procedure. The true bacteraemia rate was calculated after excluding probable "contaminated" blood cultures. A possible correlation between type of procedure performed during the bronchoscopy and occurrence of bacteraemia was investigated. Positive blood cultures were noted following 26 bronchoscopy examinations. Coagulase negative Staphylococcus was found in the cultures of 18 patients, coagulase positive Staphylococcus in 3 patients, nonhaemolytic streptococci and a Klebsiella species in 2 patients each, and beta haemolytic streptococcus in one patient. After exclusion of 13 "contaminated" specimens the bacteraemia rate was 6.5% (13/200 patients). This study showed a bacteraemia rate of 6.5%, significantly higher than previously recognized in a cohort of patients undergoing fibreoptic bronchoscopy without either pulmonary infection or an unusually high rate of invasive procedures. These findings should be taken into account in future evaluations of recommendations for antibiotic prophylaxis of endocarditis.
Methsuximide in Psychomotor and Petit-Mal Seizures
Authors: Elizabeth G. French, Jean Rey-Bellet, William G. Lennox
Journal: New England Journal of Medicine (1958)

METHSUXIMIDE (N-methyl-a,a-methylphenylsuccinimide, PM-396) has emerged from studies of many succinimide analogues as an effective antiseizure medication. Use of a related drug, methylphenylsuccinimide, was described by Zimmerman1 in 1951, and reports from a number of clinics followed, two of these2 , 3 from the Seizure Unit. Zimmerman4 , 5 investigated other succinimide preparations. In 1954 he reported that methsuximide (methylphenylsuccinimide) was effective both in petit-mal6 and psychomotor epilepsy,7 and recently8 he obtained "practical to complete" control in 44 to 50 per cent of 100 petit-mal cases refractory to other drugs. Of 35 patients with psychomotor seizures, he now reports that 37 per cent show "practical . . .
Placing Acupuncture in Perspective—Reply
Authors: Andrew J. Vickers, for the Acupuncture Trialists' Collaboration
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Don't Place Alcohol on a Pedestal
Authors: Marvin A. Block
Journal: JAMA (1976)

I DEPLORE the attempt being made by apparently qualified scientists to develop a technique whereby the proved alcoholic can be taught to drink without slipping into further dependence. This effort goes far to undermine the prime objectives of those of us who have worked in this field for many years. It seeks to elevate an addictive drug to a kind of sovereign social status so that certain of its victims may try to circumvent its deleterious effects. It flies in the face of endeavors to bring people to the realization that life can be rewarding without resort to drugs. Instead of combating the drug culture that incubates alcohol abuse and helping us to erect sound defenses against it, these comparative newcomers in the field tend rather to regard alcohol as a social necessity, whose drug effect is acceptable, even though dependence has been already established in its victims. For years,
Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression
Authors: Srinivas Mummidi, Seema S. Ahuja, Enrique Gonalez, Stephanie A. Anderson, Elvin N. Santiago, Kevin T. Stephan, Fiona E. Craig, Peter O'Connell, Victor Tryon, Robert A. Clark, Matthew J. Dolan, Sunil K. Ahuja
Journal: Nature Medicine (1998)
GMC chief retires as council votes for revalidation
Authors: K. Burke
Journal: BMJ (2001)

Sir Donald Irvine, president of the General Medical Council, is to retire early after the council voted overwhelmingly for new laws requiring doctors to prove regularly that they are fit to remain in practice.

Council members last week voted by 77 to 2 in favour of primary legislation for revalidation, with one abstention. Sir Donald chose the meeting to announce his retirement, planned for early next year. The council will vote in a new president in November. Although the BMA has often criticised Sir Donald over the GMC's revalidation plans, he insisted that his …
Both the Hippocampus and Striatum Are Involved in Consolidation of Motor Sequence Memory
Authors: Geneviève Albouy, Virginie Sterpenich, Evelyne Balteau, Gilles Vandewalle, Martin Desseilles, Thanh Dang-Vu, Annabelle Darsaud, Perrine Ruby, Pierre-Hervé Luppi, Christian Degueldre, Philippe Peigneux, André Luxen, Pierre Maquet
Journal: Neuron (2008)
Potassium deficiency during treatment with Brinaldix K.
Authors: E R Evans
Journal: BMJ (1973)

Riot Control Agent SIR,-In your leading article (7 July, p. 5) it vws reported that an improvement on the riot control CS gas is on the way.It is code-named CR and, being of low toxicity but extremely irritant to skin, eyes, nose and throat, only very little would cause con- siderable pain and discomfort.In the article there was no expression of concern or disgust that oral LD 5 tests were done on animals to test the toxicity of the compound.If a dose of very low toxicity can cause such acute symptoms when applied to the skin and mucous membranes it seems quite possible that doses of high, lethal, toxicity, even when given by other routes, will cause severe pain and distress.Does medical ethics approve the use of animals in this way in testing substances which only our own folly have made necessary?-Iam, etc., J. D. WHITTALL Rye, Sussex Haemolytic-Uraemic Syndrome with Pericarditis SIR,-We were interested in the case re- ported by Drs.J. A. Utting and D. R. Shreeve (9 June, p. 591) of a patient with haemolytic-uraemic syndrome and pericarditis.Their statement that "no cases with prominent friction rubs due to the micro- angiopathy have previously been described" is not correct.In 1972 we reported1 a case of haemolytic-uraemic syndrome and nmicroan- giepathy in a woman with a hydatidiform mole who had a strong pericardial rub and who recovered with heparin therapy.This rub also was unrelated to uraemia.-Weare, etc.,
Mercury and the Risk of Coronary Heart Disease in Men
Authors: Kazuko Yoshizawa, Eric B. Rimm, J. Steven Morris, Vickie L. Spate, Chung-cheng Hsieh, Donna Spiegelman, Meir J. Stampfer, Walter C. Willett
Journal: New England Journal of Medicine (2002)

A high dietary intake of mercury from consumption of fish has been hypothesized to increase the risk of coronary heart disease.
Cervical screening in an inner city area: response to a call system in general practice.
Authors: K. J. Shroff, A. M. Corrigan, M. Bosher, M. P. Edmonds, D. Sacks, D. V. Coleman
Journal: BMJ (1988)

To determine whether a cervical screening call system based in general practice in a deprived inner city area would increase the numbers of women who came forward for cervical smears the response to letters of invitation for screening was monitored for one year in one general practice in the Paddington and North Kensington district of London. Women aged 20-64 were identified from the computerised age-sex register. Only 16% of these women had had a smear test. A total of 750 call letters was sent out. Initially the response was poor (57 women; 22%), and 85 (32%) letters were returned marked "address unknown." After the age-sex register was updated the response to call was 330 women (44%). The response of women aged over 35 was better than the response of women aged 35 and under (229 (53%) v 101 (32%)). In the year of the study the number of women aged 20-64 on the revised register who had been screened rose by 330 (14%). A general practice based call system can improve uptake of cervical screening even in a highly mobile, socially underprivileged population.
Identification of a large set of rare complete human knockouts
Authors: Patrick Sulem, Hannes Helgason, Asmundur Oddson, Hreinn Stefansson, Sigurjon A Gudjonsson, Florian Zink, Eirikur Hjartarson, Gunnar Th Sigurdsson, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Olafur Th Magnusson, Augustine Kong, Agnar Helgason, Hilma Holm, Unnur Thorsteinsdottir, Gisli Masson, Daniel F Gudbjartsson, Kari Stefansson
Journal: Nature Genetics (2015)
How I Became a Human Being: A Disabled Man's Quest for Independence
Authors: M. Green
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
One Aspirin Can't Prevent a Stroke but Can Prevent a Major Vascular Event-Reply
Authors: Beverly Merz
Journal: JAMA (1987)

<h3>In Reply.—</h3> The title "Multicenter Study Indicates One Aspirin Can Do the Job of Four in Preventing Stroke" was chosen to convey the impression that both aspirin doses had the same effect. (The purpose of the study was to evaluate high-dose vs low-dose aspirin therapy.) Although I had not meant to imply that either dose actually prevented stroke, I can see how that inference is reasonable. Had I been more precise and used "Major Vascular Event" instead of "Stroke," the misunderstanding would have been averted. As stated, the information in the article is the result of preliminary analysis. The complete report, when published, may well explain the influence of the inclusion of the female cohort.
1155-100 Intracoronary radiation therapy using a novel beta emitter for in-stent restenosis: Tungsten WRIST
Authors: Ron Waksman, Andrew E Ajani, Christian E Dilcher, Janice K Lavoie, Rebecca Torguson, Afework GebreEyesus, Rosanna C Chan, Michael Porrazzo, Lowell F Satler, William O Suddath, Augusto D Pichard, Kenneth M Kent, Joseph Lindsay
Journal: Journal of the American College of Cardiology (2004)
OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways
Authors: Wen-Yi Wang, Jie Li, Ding Yang, Wei Xu, Ruo-peng Zha, Yi-ping Wang
Journal: Cardiovascular Research (2009)

AimsLipoprotein-associated phospholipase A2 (lp-PLA2) has been detected in human and rabbit atherosclerotic lesions, where it co-localizes with its substrate, oxidized LDL (oxLDL). Here, we investigated whether oxLDL may exert a regulatory effect on lp-PLA2 expression.
1105-174 Increased body mass index is associated with impaired endothelial function in women but not men: A NOMAS substudy
Authors: Cairistine N Grahame-Clarke, Yumiko Miyake, Robert R Sciacca, Kumiko Hirata, Carlos J Rodriguez, Bernadette Boden-Albala, Marco Di Tullio, Ralph L Sacco, Shunichi Homma
Journal: Journal of the American College of Cardiology (2004)
Tl-201 SPECT FOR ASSESSING TUMOR VIABILITY IN RECURRENT MALIGNANT NEOPLASMS OP THE BRAIN AND SOFT TISSUE
Authors: H Macapinlac, C Caluser, S Yeh, R Blesbery, R Finn, A Muraki, G DiResta, S Larson, H Abdel-Dayen
Journal: Clinical Nuclear Medicine (1992)

Macapinlac, H; Caluser, C; Yeh, S; Blesbery, R; Finn, R; Muraki, A; DiResta, G; Larson, S; Abdel-Dayen, H Author Information
Bacterial Proliferation in Platelet Products Stored at Room Temperature
Authors: Donald H. Buchholz, Viola Mae Young, Norman R. Friedman, James A. Reilly, Michael R. Mardiney
Journal: New England Journal of Medicine (1971)

A theoretical objection to ambient-temperature platelet storage is the possibility of proliferation of micro-organisms introduced into the system during phlebotomy or component preparation. After gram-negative septicemia followed platelet infusion in two patients with cancer, a study was begun to determine the frequency of contamination in platelets stored at 25°C. Culture of 2188 U of platelets, pooled in groups of eight after storage, revealed bacteria in more than 20 per cent of pools; the minimal frequency of contamination in individual units was calculated to be 2.4 per cent. Bacteria including species of corynebacterium, staphylococcus, micrococcus, streptococcus, sarcina, bacillus, herellea, pseudomonas and flavobacterium were recovered; Enterobacter (Aerobacter) cloacae was isolated seven times and caused both septicemias. Twenty-five of 143 transfusions were later shown to have contained micro-organisms. The frequency of bacterial recovery progressively increased with increasing storage time. Such platelets should be used with caution, particularly in patients lacking normal host-defense mechanisms.
Removal of a Foreign Body from the Upper Gastrointestinal Tract with a Flexible Endoscope: a Prospective Study
Authors: D. Chaves, S. Ishioka, V. Félix, P. Sakai, J. Gama-Rodrigues
Journal: Endoscopy (2004)

Background and Study Aims: There have so far been no prospective studies on the value of flexible endoscopy for removing foreign bodies in the upper gastrointestinal tract. This study presents a clinical analysis of accidents with foreign bodies and prospectively evaluates the effectiveness of flexible endoscopy for removing them. Patients and Methods: A total of 105 cases of foreign-body ingestion in the upper gastrointestinal tract were evaluated, 29 (27.6 %) in children and 76 (72.4 %) in adults. Thirty patients (28.5 %) had esophageal strictures. Results: Thirty-nine of the foreign bodies (37.1 %) consisted of food and 66 (62.9 %) were not food-related. The success rate of foreign-body extraction using only a conventional flexible endoscope and accessories for treatment was 98.0 %, and with only a polypectomy snare and rat-toothed forceps it was 91.2 %. Complications at the moment of foreign-body removal occurred in nine patients (8.6 %); there was only one (1 %) esophageal perforation. The incidence of complications related to the duration of foreign-body impaction was six (10.5 %) with foreign bodies impacted for up to 24 h, 13 (52.0 %) for those impacted for 24 - 48 h, and three (60.0 %) for those impacted for 48 - 72 h (P < 0.05). Conclusions: The flexible endoscope is an effective and safe device for removing foreign bodies from the upper gastrointestinal tract, with a high success rate using only the polypectomy snare and the rat-toothed forceps as accessories. If foreign-body impaction lasts for more than 24 h, there is a significant increase in the incidence of complications.
Unicef appeals for $1bn to help children and women in humanitarian emergencies
Authors: J. Zarocostas
Journal: BMJ (2009)

Unicef has launched its 2010 appeal for humanitarian action, seeking $1.2bn (£0.8bn; €0.9bn) from donors to help millions of children and women affected by emergencies in 28 countries around the globe, including earthquake hit Haiti.

Many children are at risk in Haiti because of the emergency; but millions are also suffering elsewhere from conflict, disasters, and displacement, said Hilde Johnson, Unicef’s deputy executive director.

The agency was launching a campaign in Haiti aimed at vaccinating half a million children under the age of 7 against major killers such …
Lack of prognostic significance of CD34 expression in adult AML when FAB M0 and M3 are excluded
Authors: Katsunori Kyoda, Shinobu Nakamura, Noritaka Hattori, Minoru Takeshima, Kiku Nakamura, Hiroyasu Kaya, Sadaya Matano, Hirokazu Okumura, Masatoshi Kanno, Shigeki Ohtake, Tamotsu Matsuda
Journal: American Journal of Hematology (1998)