tbuckley/cabot-search huggingface dataset:
Individualizing Treatment of Patients With Myeloma in the Era of Novel Agents
Authors: Jesús San-Miguel, Jean-Luc Harousseau, Douglas Joshua, Kenneth C. Anderson
Journal: Journal of Clinical Oncology (2008)

Progress in the understanding of multiple myeloma (MM) cell biology has led to the identification of new relevant prognostic factors and subsequently different risk groups. This concept, together with the recent discovery of new drugs with novel mechanisms of action, will probably lead to individualized treatment according to the different patients' characteristics. In this review, we focus on current available agents already approved for MM, and discuss individualized treatment approaches for both transplantation candidates (subdivided into standard and high-risk patients) and elderly patients. Future progress in MM will be based on using science to inform the design of the optimal combined treatments, and high throughput assays that can assess the ability of combination therapies to induce death of MM cells, both alone and in the bone marrow microenvironment.
A pilot study of chronic, low-dose epoetin-β following percutaneous coronary intervention suggests safety, feasibility, and efficacy in patients with symptomatic ischaemic heart failure
Authors: Martin W. Bergmann, Sven Haufe, Florian von Knobelsdorff-Brenkenhoff, Heidrun Mehling, Ralf Waßmuth, Ines Münch, Andreas Busjahn, Jeanette Schulz-Menger, Jens Jordan, Friedrich C. Luft, Rainer Dietz
Journal: European Journal of Heart Failure (2011)
Transition from Pituitary-Dependent to Adrenal-Dependent Cushing's Syndrome
Authors: A R Hermus, G F Pieters, A G Smals, G J Pesman, S W Lamberts, T J Benraad, U J van Haelst, P W Kloppenborg
Journal: New England Journal of Medicine (1988)

PITUITARY-DEPENDENT bilateral adrenocortical hyperplasia (Cushing's disease) is present in 70 to 80 percent of all patients with Cushing's syndrome. In 20 to 40 percent of patients with Cushing's disease, macroscopic adrenocortical nodules, surrounded by hyperplastic cortical tissue, are found, usually in both adrenal glands (macronodular hyperplasia).1 Most probably, macronodular hyperplasia is a later stage of diffuse hyperplasia, developing under the influence of long-standing endogenous hyperadrenocorticotropinism.1 In recent years it has been shown that in some patients with pituitary-dependent Cushing's syndrome, a unilateral adrenal nodule suggestive of a cortical adenoma can develop.2 3 4 5 It has been postulated, but never conclusively demonstrated, that . . .
Damages and supervening illness: nofault compensation
Authors: A M Morris
Journal: BMJ (1981)

finding of increased calcitonin concentrations in postmenopausal women by Cundy et a17 has not been confirmed.The same authors have recently reported that calcitonin in very low doses appears to have a definite effect on the skeleton.'Their suggestion that calcitonin remains a hormone seeking a function in man now seems increasingly naive.
Impact of new home oxygen service on respiratory units
Authors: J K Quint, L Ward, M Monaghan, S O Ansari, K G Lingam, A G Davison
Journal: Thorax (2006)

Impact of new home oxygen service on respiratory units ''Clinical Consensus on COPD'', organised by Reed Medical Education, is a new European event for primary and secondary healthcare professionals to tackle challenging issues centred on the latest clinical best practice in COPD diagnosis, management and therapy.A two-day conference will be held in London on 2-3 March 2007.For further information visit www.clinical-consensus-copd.com.
IMMUNOLOGICAL RELATIONSHIPS OF ENCAPSULATED AND CAPSULE-FREE STRAINS OF ENCAPSULATUS PNEUMONIÆ (FRIEDLÄNDER'S BACILLUS)
Authors: Louis A. Julianelle
Journal: The Journal of Experimental Medicine (1926)

1. "S" strains of Friedländer's bacillus produce capsules, soluble specific substance, and are of exalted virulence. "S" strains are type-specific and react with only the type-specific antibodies of the homologous types. 2. Immunization with "S" cells induces the formation of antibodies which agglutinate type specifically, precipitate the corresponding soluble specific substance, and protect white mice against infection caused by organisms of the same type. 3. "R" strains of Friedländer's bacillus produce no capsules, produce no soluble specific substance, and are not pathogenic. "R" strains are serologically undifferentiated from each other and react with only the species antibodies. 4. Immunization with "R" cells induces antibodies which do not agglutinate encapsulated organisms, do not precipitate soluble specific substance, and do not afford protection against infection by Friedländer's bacillus. Anti-R serum contains only the species antibody which reacts with any capsule-free organism regardless of its type origin. 5. Decapsulation of "S" cells by heat and acid chemically converts a type-reacting organism into a species-reacting organism.
THE NATIONAL PHYSICIANS COMMITTEE
Authors: Edward H. Cary
Journal: JAMA (1949)

<i>The National Physicians Committee has sent the following letter to all of its contributors and to coordinating organisations.</i>—Ed. Ten years ago, a group of officers and fellows of the American Medical Association realized that the American Medical Association was not as active in certain functions as was deemed necessary, some of which seemed at that time inappropriate for the American Medical Association to perform. As a result, the National Physicians Committee for the Extension of Medical Service was created and has worked during these intervening years within the policies established by the House of Delegates of the American Medical Association. Several times during those years, the House of Delegates has expressed confidence in the work of this organization. Two years ago, a Committee of the House of Delegates reported that "the American Medical Association should and must do its own public relations work." In December, 1948, the House
Effect of CD3δ Deficiency on Maturation of α/β and γ/δ T-Cell Lineages in Severe Combined Immunodeficiency
Authors: Harjit K. Dadi, Amos J. Simon, Chaim M. Roifman
Journal: New England Journal of Medicine (2003)

Three closely related infants with a form of severe combined immunodeficiency characterized by the absence of T cells but normal numbers of B cells were found to have an identical germ-line mutation in the CD3δ gene. The mutation prevented synthesis of the CD3δ protein and was associated with a block early in the development of thymocytes into mature T cells.
Abstract 5042: Using a statewide collaborative approach to improve tobacco cessation referral rates for cancer patients
Authors: Jane Severson, Hilary Baca, Douglas Blayney, Karen Brown, Grayce Galiyas, Mara Minasian, Joan Schmidt, Anna Schulze, Graham Warren
Journal: Cancer Research (2014)

Abstract Purpose: Though tobacco use by cancer patients is associated with poor therapeutic outcomes, most oncologists do not regularly provide tobacco cessation support for cancer patients. The purpose of this study was to determine if dedicated statewide services could substantially enhance delivery of evidence based cessation support to broad cancer patient populations across many oncology clinics. Methods: The Michigan Oncology Quality Consortium (MOQC) collaborated with the Michigan Department of Community Health and the Michigan Cancer Consortium to identify and address tobacco cessation support that could be improved for cancer patients. A statewide Tobacco Cessation Demonstration Project was developed to reduce patient barriers to access by increasing education, identifying all cancer patients who use tobacco, referring them to the Michigan Tobacco Quitline, and providing funding for free Quitline telephone counseling services and nicotine replacement therapy for cancer patients. Reported are results in 19 clinical practices. Results: Implementation of this project resulted in tobacco assessments in more than 98% of patients and increased tobacco cessation referral rates for participating practices from 15% in May 2013 to over 60% in July and September of 2013 (p &amp;lt; .001). Total statewide referrals to the Quitline increased by between 32% and 60% over the first 6 months, with an increasing proportion of patients (between 31% and 50%) being cancer patients referred by MOQC participating sites. FebMarAprMayJunJulAugSepOctTotal Michigan # Referrals140153153202233245238220210MOQC # Referralsn/an/an/a628812397104102MOQC Referrals % of Total Michigann/an/an/a31%38%50%41%47%49% Conclusions: Reducing patient barriers to access to tobacco cessation services and supplying clinic teams with scientific evidence, standard workflows, and lean tools improved the referral rate to a tobacco cessation program for oncology patients. Critical factors for success included strong physician leadership, adoption of an auto referral process, and front line staff accountability for identifying all patients who use tobacco and assessing their tobacco cessation status at subsequent clinic visits. Citation Format: Jane Severson, Hilary Baca, Douglas Blayney, Karen Brown, Grayce Galiyas, Mara Minasian, Joan Schmidt, Anna Schulze, Graham Warren. Using a statewide collaborative approach to improve tobacco cessation referral rates for cancer patients. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5042. doi:10.1158/1538-7445.AM2014-5042
Toxoplasmosis in cardiac transplantation.
Authors: M Hakim, D Esmore, J Wallwork, T A English, T Wreghitt
Journal: BMJ (1986)

T cell lymphotropic virus type III antibodies; filaria and schistosomal enzyme linked immunosorbent assay; testing of stools for ova and parasites; tests of liver function and autoantibodies; chest radiography; and abdominal ultrasound.Immunoglobulim,concentrations were normal apart fromi a slightly raised IgM.Skin biopsies on admission showed focal parakeratosis with acanthosis of the epidermis, in which numerous convoluted lymphocytes were identified.A repeat skin biopsy taken three week-s later when the skin had improved showed a perivascular lymphocytic infiltrate.Biopsy of the lymph nodes was consistent with a dermatopathic lymphadenitis.The erythroderma improved,,but the patient still required 5 mg prednisolone on alternate days and a moderately potent (group III) topical steroid cream five months after onset ofillness.
Fractional flow reserve, absolute and relative coronary blood flow velocity reserve in relation to the results of technetium-99m sestambi single-photon emission computed tomography in patients with two-vessel coronary artery disease
Authors: Steven A.J Chamuleau, Martijn Meuwissen, Berthe L.F van Eck-Smit, Karel T Koch, Angelina de Jong, Robbert J de Winter, Carl E Schotborgh, Matthijs Bax, Hein J Verberne, Jan G.P Tijssen, Jan J Piek
Journal: Journal of the American College of Cardiology (2001)
Effect of prostaglandin E1 on certain renal actions of parathyroid hormone
Authors: Nama P. Beck, Frederick R. DeRubertis, Michael F. Michelis, Robert D. Fusco, James B. Field, Bernard B. Davis
Journal: Journal of Clinical Investigation (1972)

Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E(1) (PGE(1)). Tissue cyclic 3',5'-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE(1). Both parathyroid hormone and dibutyryl cyclic AMP increased (32)P incorporation into renal cortical phospholipids. PGE(1) diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE(1) likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE(1) inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex.
STUDIES ON CYANOSIS
Authors: Christen Lundsgaard
Journal: The Journal of Experimental Medicine (1919)

These data prove that abnormally high oxygen unsaturation of the blood is a cause of cyanosis. The fact that the lowest value of oxygen unsaturation (in the venous blood) associated with cyanosis is about 8 volumes per cent seems to indicate that this amount of reduced hemoglobin is the lowest capable of producing a cyanotic color. We shall later discuss this point more in detail. Table III shows furthermore that in spite of the fact that cyanosis is due to abnormally high oxygen unsaturation, no proportionality exists between the intensity of the blue color and the amount of reduced hemoglobin. This may in small part be due to individual peculiarities of the skin and subcutaneous tissue, which are known to influence in anemia the relation between paleness of the skin and the decrease in hemoglobin. We shall, however, in the succeeding paper show that the main cause of the disproportionality between cyanosis and venous oxygen unsaturation is found in another factor, the recognition of which throws a clearer light on the pathogenesis of cyanosis, and explains why we may find values of oxygen unsaturation as high as 13 volumes per cent in non-cyanotic individuals.
Myocardial Infarction and the G.P
Authors: J. L. Struthers
Journal: BMJ (1970)

MDICBLOUNAL 681 be expected in patients with folic acid deficiency (clinical or subclinical).The find- ings of Kaimis, Sumrnerly, and Giles (per- sonal cormmunication to Marks and Shuster, 12 September, p. 618) and the demon- stration of malabsorption in the proximnal small bowel' which is the site of absorption of folic acid, would seem to indicate that, in addition to an increased demand, there may be malabsorption of folic acid in these patients which would further exacerbate folate deficiency.As correctable malabsorption of vitamin B12 has been described in patients with folic acid deficiency,9"0 it would seem likely that the malabsorption of vitamin B12 in patients with various skin diseases is also due to folic acid deficiency.I wonder whether the authors have repeated the study after a course of folic acid.It would also be interesting to see whether the small bowel dysfunction in dermatogenic enteropathy reverts to normal on folic acid therapy alone without local treatment of the rash.If it does (as I suspect) in addition to the local treatment of dermatosis early folic acid therapy would seem to be indicated in patients with enteropathy, even when there are no obvious haematological changes.Similar explanation probably holds true in enteropathy associated with various chronic debilitating illnesses and also in conditions where increased cellular proliferation is a predomiunant feature.-Iam, etc.,
Asthma presenting as cor pulmonale.
Authors: P A Corris, G J Gibson
Journal: BMJ (1984)

3 observations: sujets jeunes atteints d'hypoxemie, hypercapnie, retention hydrique, polycythemie, presentant des difficultes de diagnostic. Ils sont d'abord envoyes aux cardiologues, avec suspicion de Shunt droit→gauche ou d'hypertension pulmonaire inexpliquee. Les examens plus pousses et surtout les resultats des traitements montrent qu'il s'agit d'asthme
Acute barrier disruption by adhesive tapes is influenced by pressure, time and anatomical location: integrity and cohesion assessed by sequential tape stripping; a randomized, controlled study
Authors: M. Breternitz, M. Flach, J. Präßler, P. Elsner, J.W. Fluhr
Journal: British Journal of Dermatology (2006)

Tape stripping is an established procedure in stratum corneum (SC) physiology research. Adhesive films are pressed to the surface of the skin and then removed. The superficial layers of the SC adhere to the film and are accessible for further investigations. Although this method is widely used, only scant information about standardization is known. Various protocols are used but are difficult to compare.The aim of the present study was to investigate the effects of the type of tape, pressure, time, anatomical site and type of applied pressure.Twelve healthy volunteers (age range 20-31 years) were entered in a randomized, controlled study with sequential tape stripping at the volar forearm, upper arm, cheek and back. Different methods (roller, stamp, thumb, stretched skin), total duration of applied pressure (2 s, 10 s), degrees of pressure (2 N stamp, 7 N stamp) and different tapes (D-Squame, Corneofix, Blenderm) were investigated and the impact on barrier function assessed by transepidermal water loss measurements. Furthermore, measurements of SC hydration, skin colour and skin surface pH were performed. Spectroscopic measurements and a Bradford protein assay to determine the mass of removed SC were carried out in parallel.The degree of barrier disruption, irritation and SC cohesion is influenced by the character of adhesive tapes, total duration of applied pressure (2 s, 10 s; 2 N, 7 N), the kind of method for pressure application (roller, stamp, thumb, stretched skin), anatomical site and condition before stripping (occlusion vs. nonocclusion). The spectroscopic assessment and Bradford protein assay determination showed a significant correlation (P < 0.0001; r = 0.7041).The present study showed significant differences between different factors on controlled barrier disruption. The results indicate the importance of defining these factors when a study is initiated and when results of different studies should be compared. Based on our data we propose using a 2 N stamp for a duration of 2 s on 15 sequential D-Squame tape strips on the volar forearm and then discarding the first and second strips. This approach allows the performance of a standardized study with a reasonable amount of resources.
Gout epidemiology: results from the UK General Practice Research Database, 1990-1999
Authors: Ted R Mikuls, J. T. Farrar, W. B. Bilker, S. Fernandes, H. R. Schumacher, K. G. Saag
Journal: Annals of the Rheumatic Diseases (2005)

To examine the epidemiology of gout and gout treatment in the United Kingdom using a large national practice based population.Data from the UK General Practice Research Database from 1990 to 1999 were examined. Physician diagnoses and drug codes were used, and trends in gout incidence and treatment examined. Additionally, disease prevalence for the year 1999 was assessed. To examine the association of gout with comorbid disease, the prevalence of select health conditions and drug use was compared with the corresponding prevalences seen in osteoarthritis, adjusting for both age and sex.From 1 January 1990 to 31 December 1999 overall gout incidence remained relatively stable, ranging from a low of 11.9 cases (95% confidence interval (CI) 11.5 to 12.3) in 1991 to a high of 18.0 cases (95% CI 17.6 to 18.4) per 10 000 patient-years in 1994. Gout prevalence in 1999 was 1.4% with rates approaching 7% in men over the age of 65. Drugs used for the treatment of gout remained constant in prevalent cases with the exception of a significant decline in non-steroidal anti-inflammatory drug use over the 10 year follow up. Compared with patients with osteoarthritis, patients with gout were significantly more likely to have cardiovascular disease, hypertension, diabetes, and chronic renal failure, and were more likely to have used diuretics or ciclosporin, or both.Although gout is common in the UK, particularly among older men, the incidence of the disease seems to have remained stable during the 1990s.
Life expectancy of Russian men falls to 58
Authors: J. Ciment
Journal: BMJ (1999)

The transition to market economies in many post-communist societies of the former Soviet Union and other former eastern bloc countries in Europe has a produced a “demographic collapse,” a recent report by the United Nations Development Programme has found. Among the most serious findings is a four year drop in life expectancy among Russian men since 1980, from 62 years to 58.

The development programme's report also noted significant drops in life expectancy in Armenia, Belarus, Bulgaria, Latvia, Lithuania, …
The Thanatos Syndrome
Authors: Don Riesenberg
Journal: JAMA (1987)

During his pathology residency at Bellevue, Walker Percy developed tuberculosis, whereupon he left the famous New York hospital for Lake Saranac, the equally famous Adirondacks sanatorium. There he undertook selfeducation in philosophy and psychology. (The details of this transformation from physician to litterateur appear in Robert Coles'<i>Walker Percy: An American Search</i>, Boston, Atlantic Monthly Press, 1978.) Since then, the Louisiana-based writer has displayed an impressive range: essays, journal articles, and novels, for which he is best known. A favorite Percy novel is<i>Love in the Ruins</i>(1971), the story of Dr Thomas More (comparison with the 16th-century English statesman is encouraged). More is a psychiatrist who endures bizarre people and events, but retains a remarkable tranquility, not to say optimism. One comes away from<i>Love in the Ruins</i>feeling that the world is lamentable and laughable, but liveable as well. In<i>The Thanatos Syndrome</i>, Tom More is back, after
Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial
Authors: Ali Al-Khafaji, Michele Elder, Daniel J. Lebovitz, Raghavan Murugan, Michael Souter, Susan Stuart, Abdus S. Wahed, Ben Keebler, Dorrie Dils, Stephanie Mitchell, Kurt Shutterly, Dawn Wilkerson, Rupert Pearse, John A. Kellum
Journal: Intensive Care Medicine (2015)