tbuckley/cabot-search huggingface dataset:
Quinidine and Granulomatous Hepatitis
Authors: T. CHAJEK
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 February 1975Quinidine and Granulomatous HepatitisT. CHAJEK, M.D.T. CHAJEK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-2-282_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After our paper "Quinidine-Induced Granulomatous Hepatitis" in the December issue (Ann Intern Med81:774-776, 1974) went to press, we observed a similar case. The patient was a 64-year-old man who received quinidine sulfate, 800 mg daily, for 12 days to prevent recurrence of atrial fibrillation. On the 12th day this medication was discontinued because of fever up to 39 °C and elevation of serum alkaline phosphatase and serum glutamic-oxalacetic transaminase. One day after discontinuation of quinidine, the temperature returned to normal, and a slow decrease to normal of the serum enzyme concentrations was observed. One month later... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hadassah Medical Organization Jerusalem, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRepublished: Quinidine hypersensitivity: a side effect of a forgotten antiarrhythmicQuinidine hypersensitivity: a side effect of a forgotten antiarrhythmicQuinidineGranulomas and cholestatic-hepatocellular injury associated with phenylbutazoneAn Unusual Case of Quinidine-induced Systemic Disease as an Exercise in Clinical Decision-makingQuinidine, HepatotoxicityQuinidine Hypersensitivity and Liver Involvement 1 February 1975Volume 82, Issue 2Page: 282-282KeywordsAminotransferasesAtrial fibrillationAttentionEnzymesFeversHepatitis APhosphatasesSulfatesTemperature Issue Published: 1 February 1975 PDF downloadLoading ...
Significant Correlation Between the Degree of WT1 Expression and the International Prognostic Scoring System Score in Patients With Myelodysplastic Syndromes
Authors: Daniela Cilloni, Enrico Gottardi, Francesca Messa, Milena Fava, Patrizia Scaravaglio, Marilena Bertini, Mauro Girotto, Carlo Marinone, Dario Ferrero, Andrea Gallamini, Alessandro Levis, Giuseppe Saglio
Journal: Journal of Clinical Oncology (2003)

To determine whether pattern of WT1 gene expression is a useful marker for establishing prognosis and tracking disease progression in patients with myelodysplastic syndromes (MDS).We performed a quantitative assessment of the WT1 transcript amount by real-time quantitative polymerase chain reaction (RQ-PCR) in 173 samples (131 bone marrow samples and 42 peripheral-blood samples) from 131 patients with MDS (79 patients with refractory anemia [RA], 31 with RA with excess blasts [RAEB], 18 with secondary acute myeloid leukemia [s-AML] evolved from MDS, and three with deletion of 5q as the sole cytogenetic abnormality). Values obtained were correlated with the blast percentage and International Prognostic Scoring System (IPSS) score.Sixty-five percent of BM and 78% of PB samples for RA and 100% of BM and PB samples of RAEB and s-AML expressed WT1 transcript amounts greater than the level observed in healthy volunteers. The degree of WT1 expression was highly correlated with the type of MDS, was much higher in RAEB and s-AML compared with RA, and increased during disease progression. Moreover, a significant correlation was found between WT1 expression levels, blast cell percentage, and the presence of cytogenetic abnormalities. Therefore, we found a significant correlation between the amount of WT1 transcripts and the IPSS score, which currently represents the most reliable risk index of disease progression available for MDS patients.WT1 is a useful molecular marker for risk assessment in MDS patients.
Mechanisms subserving the trophic actions of insulin on ovarian cells. In vitro studies using swine granulosa cells
Authors: Johannes D. Veldhuis, Lisa A. Kolp, Michael E. Toaff, Jerome F. Strauss, Lawrence M. Demers
Journal: Journal of Clinical Investigation (1983)

Direct actions of insulin on gonadal tissues have been difficult to demonstrate in vivo. We have developed an in vitro system in which swine ovarian cells remain highly responsive to trophic actions of insulin. Purified porcine insulin significantly augmented the biosynthesis and secretion of progesterone by cultured granulosa cells. These stimulatory actions of insulin were dose- and time-dependent and saturable. Under serum-restricted conditions, insulin also significantly amplified the capacity of estradiol and 8-bromo cyclic AMP to stimulate progesterone production. Inhibitors of protein and RNA synthesis (cycloheximide, actinomycin D, and alpha-amanatin) inhibited insulin action. The stimulation of progesterone production by insulin was attributable to increased biosynthesis of pregnenolone, rather than diminished catabolism of progesterone to its principal metabolite, 20α-hydroxypregn-4-en-3-one. Insulin also enhanced progesterone production in the presence of a soluble sterol substrate, 5-cholesten-3β,25-diol, which readily gains access to the mitochondrial cholesterol side-chain cleavage system. Moreover, exposure of granulosa cells to insulin produced a three- to sevenfold increase in mitochondrial content of cytochrome P-450 measured by difference spectroscopy, with a corresponding increase in mitochondrial cholesterol side-chain cleavage activity.
Origin of the third heart sound.
Authors: E. B. Raftery
Journal: BMJ (1969)

Important circumstantial evidence in support of the theory of passive dilatation of the ventricle is provided by consideration of the abnormal but characteristic ventricular cardiographic silhouettes after mitral valve replacement using low-profile disc and central-flow homograft valves.As a result of some preliminary observations we would distinguish the " turnip " heart outline that characterizes the disc valves from the " pear " heart of the homograft valve, and suggest that the shape adopted by the ventricle is determined by the grossly abnormal filling patterns in each case."It seems logical that the reduction in cardiac output that is uni- formly observed in these patients is related directly to these changes.-Iam, etc.,
Abstract 1480: The Wnt Antagonist Dickkopf-1 (Dkk-1) Targets Endosteal Cells of the Bone Marrow Stem Cell Niche and Mobilizes Endothelial Progenitor Cells
Authors: Alexandra Aicher, Christopher Heeschen, Stefan Liebner, Michael Potente, Stefanie Dimmeler, Andreas M Zeiher
Journal: Circulation (2006)
TRAINING THE ENLISTED PERSONNEL OF A BASE HOSPITAL
Authors: EUGENE S. KILGORE
Journal: JAMA (1918)

The scheme for organizing the first fifty base hospitals for the new United States Army by the Red Cross in conjunction with civil hospitals and medical schools, had for its primary object the suitable grouping of specialists. A less obvious result, but another important one, has been the selection for these units of a relatively high percentage of enlisted men with college and other special training. Instead of simplifying the process of training, which at first would appear to be the result of such selection, the problem has really been made more complicated. For, while the courses in nursing, first aid, etc., ordinarily prescribed for sanitary troops are quickly covered by men with these qualifications, such training is inadequate, for the reason that it falls short of preparing them as well as they can be for the special work of a base hospital. Our method of meeting this situation is
CMR-Guided Approach to Localize and Ablate Gaps in Repeat AF Ablation Procedure
Authors: Felipe Bisbal, Esther Guiu, Pilar Cabanas-Grandío, Antonio Berruezo, Susana Prat-Gonzalez, Bárbara Vidal, Cesar Garrido, David Andreu, Juan Fernandez-Armenta, Jose María Tolosana, Elena Arbelo, Teresa M. de Caralt, Rosario J. Perea, Josep Brugada, Lluís Mont
Journal: JACC. Cardiovascular imaging (2014)
Nevomelanocytic proliferations in association with cutaneous malignant melanoma: A multivariate analysis
Authors: Stephen B. Gruber, Raymond L. Barnhill, Kurt S. Stenn, George C. Roush
Journal: Journal of the American Academy of Dermatology (1989)

Two hundred forty-eight cases of melanoma accessioned from 1984 through 1985 were independently reviewed by a panel of dermatopathologists for the presence of nevomelanocytic proliferations in histologic contiguity with melanoma. One hundred ninety-seven cases remained in the sample for analysis after cases with insufficient histologic material and those diagnosed without primary melanoma were excluded. We found that 32.5% of melanomas (95% confidence interval, 25.9% to 39.7%) were associated with a benign or dysplastic nevus in histologic contiguity. Melanoma type and anatomic location were significant predictors of contiguous nevomelanocytic proliferations when considered alone. After adjustment, however, only melanoma type significantly predicted the presence of a contiguous histologic evidence of a precursor nevus than was nodular melanoma (odds ratio, 11.1; 95% confidence interval, 1.4 to 86.6) and were almost 22 times more likely to be associated with a nevus than was lentigo maligna melanoma (odds ratio, 21.45; 95% confidence interval, 2.8 to 162.4). This evidence supports the concept of the heterogeneity of melanoma histogenesis.
Isolated Systolic Hypertension in the Elderly
Authors: Aram V. Chobanian
Journal: New England Journal of Medicine (2007)

A 68-year-old accountant visits his physician. A year earlier he was told that his blood pressure was somewhat elevated and was advised to reduce salt intake and increase activity. Otherwise, he has been in good health and has no history or signs of cardiovascular or renal disease. On physical examination, his blood pressure is 178/72 mm Hg, and his body-mass index is 28.4. How should he be further evaluated and treated?
Unilateral Renal Disease Causing Hypertension
Authors: Thomas A. Stamey
Journal: JAMA (1976)

ALTHOUGH several clinicians have suggested that the incidence of curable renovascular hypertension (RVH) is 5% to 10% of the total hypertensive population, the true incidence seems much less than these estimates. On the other hand, considering the rarity of pheochromocytomas, coarctations of the aorta, and aldosteroneproducing adrenocortical adenomas, RVH is clearly the most common form of surgically correctable hypertension. There is no debate that RVH is clinically indistinguishable from essential hypertension; differences are quantitative rather than qualitative. One of the most interesting and least debatable studies to come from the National Cooperative Study of Renovascular Hypertension compares the clinical characteristics of 131 matched pairs of patients with essential hypertension and patients with proved, curable RVH.<sup>1</sup>Although all clinical and laboratory differences in Table 1 are statistically significant, essential hypertension is at least 20 times more common in any hypertensive population, so any of these features is more likely to be associated with essential hypertension than with RVH. Precisely because RVH is clinically indistinguishable from essential hypertension, all hypertensive patients
Domestic violence and pregnancy
Authors: G. C Mezey, S. Bewley
Journal: BMJ (1997)

Domestic violence is reported by up to one in four women in Britain1 and represents a serious public health issue. The psychological and social consequences of domestic violence include alcohol and drug dependence, suicide attempts, depression, and post-traumatic stress disorder.2 3 Pregnancy may increase the risk of violence,4 5 6 7 and the pattern of assault may alter, with pregnant women being more likely to have multiple sites of injury and to be struck on the abdomen.4 5 6 7 However, the risk of moderate to severe violence appears to be greatest in the postpartum period.8

Several studies have found that women attending accident and emergency departments with physical injuries due to domestic violence are more likely to be pregnant than women attending with accidental injuries. …
CONCUSSION OF THE BRAIN SIMULATING CEREBRAL HEMORRHAGE.
Authors: CARROLL W. ALLEN
Journal: JAMA (1907)

The following case of concussion of the brain furnishes an interesting clinical history and instructive operative findings:  History.  —M., male, aged 25, jockey by occupation, fell from his horse in a hurdle race and it is supposed was kicked in the head. Admitted to hospital March 7.  Examination (ambulance notes).  —When first seen the patient was unconscious, respiration stertorous, pulse full, slow and bounding; reacted to painful stimuli on either side; pupils were moderately dilated and unequal; right corneal reflex slower than left. The face was congested and there was a lacerated wound of the scalp over the right parietal bone. On the way to the hospital the patient's breathing ceased to be stertorous and he reached up with the left hand and unbuttoned undershirt. On being pinched, movements of the face were apparently equal. On arrival at the hospital he reacted slightly to painful stimuli in the right leg,
Relationship of different platelet response criteria and patient outcomes in a romiplostim myelodysplastic syndromes trial
Authors: U Platzbecker, M A Sekeres, H Kantarjian, A Giagounidis, G J Mufti, C Jia, A S Yang, P Fenaux
Journal: Leukemia (2014)

Sustained AKT activation was also detected in imatinibtreated Lin -CD34 + CD38 -LSCs and Lin -CD34 + CD38 + LPCs when compared to imatinib-naive counterparts (Figure 2b).However, perifosine reduced ROS levels in imatinib-naive and imatinib-treated Lin -CD34 + CD38 + LPCs but not in Lin -CD34 + CD38 -LSCs (Figure 2b).Therefore it appears that AKT kinase plays an important role in generation of ROS in imatinib-naive and imatinib-treated Lin -CD34 + CD38 + LPCs, but it is expendable in Lin -CD34 + CD38 -LSCs.Since accumulation of DNA lesions such as 8-oxoG and DSBs directly depends on ROS levels in Lin - CD34 + CD38 -LSCs and Lin -CD34 + CD38 + LPCs, 5,8 we postulate that AKT kinase regulates oxidative DNA damage in LPCs, but not in LSCs.In conclusion, we hypothesize that in imatinib-treated CML-CP patients AKT serine/threonine kinase plays a prominent role in accumulation of TKIR clones emerging from Lin -CD34 + CD38 + LPCs, but probably not from Lin -CD34 + CD38 -LSCs.The mechanisms responsible for this cell compartment-specific AKT-mediated effect on genomic instability in CML-CP are unknown.Although AKT remained active in imatinib-treated Lin -CD34 + CD38 + LPCs and Lin -CD34 + CD38 -LSCs, intrinsic differences between leukemic progenitor and stem cells may contribute to the selective AKT effect in LPCs. 15Moreover, it remains to be determined if AKT and RAC employ overlapping or different downstream signaling pathways.
Withdrawal reaction from clobazam.
Authors: H Petursson, M H Lader
Journal: BMJ (1981)

sounds, and there was generalised rebound tenderness but no muscular rigidity or hepatosplenomegaly.Rectal and pelvic examination were painful but normal.Neurological examination showed no abnormalities.Laboratory values were: erythrocyte sedimentation rate 5 mm in first hour; haemoglobin 15-3 g/dl; packed cell volume 47%O; leucocytes 78 x 109/1, with a shift to the left; thrombocytes 128 x 109/1; serum amylase 1110 U/I (normal < 340 U/1); aspartate transaminase 43 U/I (normal < 17 U/1); alanine transferase 42 U/I (normal <21 U/1); lactate dehydrogenase 321 U/I (normal <200 U/i); direct Coombs negative.Electrolytes, blood glucose, renal function, and urine analysis were normal.Chest x-ray examination showed cystic abnormalities of the left lung; abdominal x-ray examination was normal.Pancreatitis caused by choledochal obstruction was suspected and all oral drugs stopped.Within two days the fever, confusion, and hyperamylasaemia had disappeared.Retrograde cholangiopancreatography showed two stones in the gall bladder but normal choledochal and pancreatic ducts.Drug-related pancreatitis was suspected and with informed consent she was rechallenged with 250 mg methyldopa.Within three hours the same symptoms had developed.Serum amylase activity rose from normal to 2105 U/I in 12 hours, serum lipase activity rose to 1200 U/1, and a transient leucocytosis with left shift developed.All symptoms subsided in 36 hours; serum amylase and lipase activities normalised within five days.
A multicenter, randomized, double-blind trial of somatostatin in the management of acute hemorrhage from esophageal varices
Authors: Jorge E. Valenzuela, Timothy Schubert, Ronald M. Fogel, Richard M. Strong, Joel Levine, Peter R. Mills, Thomas L. Fabry, Linda W. Taylor, Harold O. Conn, James T. Posillico
Journal: Hepatology (1989)

A prospective, randomized, placebo–controlled, double–blind, multicenter clinical trial of intravenous somatostatin (Stilamin®; Serono Laboratories, Inc., Randolph, MA) was performed in 102 patients with actively bleeding esophageal varices from August, 1985, to November, 1986. Patients had major hemorrhage indicated by hematemesis or melena and evidence of significant blood loss. For entry, patients had to have endoscopic demonstration of active bleeding from esophageal varices or stigmata of recent hemorrhage and bright red blood in the gastric aspirate with no other source of bleeding found. Randomized patients received identical appearing somatostatin or placebo for a 30–hr study period. Those given somatostatin received a 250–μg bolus and a 250–μg per hr infusion with repeat bolus and doubling of the infusion if the bleeding was not controlled. In retrospect, 18 patients could not be evaluated. Of the 84 evaluable patients, 48 received somatostatin and 36 placebo. They were comparable in age, gender, severity of liver disease and history of variceal bleeding. Transfusion requirements were similar in both groups. Bleeding stopped for 12 consecutive hr during 30 hr of the study period in 31 (65%) of the somatostatin group vs. 30 (83%) of the placebo group (p = 0.06). The median time to cessation of bleeding was 2 hr in the placebo group and 3 hr in the somatostatin group. Deaths following the study period were nine (25%) in the placebo group and 15 (31%) in the somatostatin group. Within the limitations of the present study, we conclude that somatostatin was ineffective in the management of active bleeding of esophageal varices.
Current treatment of rheumatoid arthritis
Authors: A. K. Gough, J. Foo
Journal: BMJ (2011)

Spence makes some challenging observations about rheumatoid arthritis.1 His assertion that it is becoming less common is difficult to answer as current criteria are different from those used in the 1950s, when most forms of inflammatory arthritis were thought to be rheumatoid. His view that the disease is now milder is also impossible to answer as treatment outcomes have improved dramatically. How can we …
Update on squint and amblyopia
Authors: G G W Adams, J J Sloper
Journal: Journal of the Royal Society of Medicine (2003)

At birth a baby's vision is very immature, with an acuity of around 3/601,2. Visual experience in infancy and childhood has a major influence on the development of the visual pathways, particularly the visual cortex3,4. During the critical periods of visual development visual acuity develops as do other modalities such as contrast sensitivity, colour, pattern and motion perception, and binocular function with stereopsis1,2. Disturbance to normal visual development will affect the maturation of these different visual functions, with associated structural changes in the visual pathways and cortex, resulting in amblyopia—i.e. reduced acuity in one or sometimes both eyes without any ocular lesion. Either these children lose binocular function as a result of a squint or they acquire a squint because of poor development of binocular function. The commonest causes for amblyopia are a squint (strabismic amblyopia) or blurring of the image in one eye due to unequal refractive power in the two eyes (anisometropic amblyopia). Psychophysical tests show differences between strabismic and anisometropic amblyopia, but for the patient the effects are similar.

Squint and amblyopia are common conditions: about one in fifty children have a squint5, and up to 5% of the population have an amblyopic or lazy eye6,7. In view of their lifelong impact on visual function and physical appearance, with consequences for education, jobs and psychological wellbeing8, good management offers substantial long-term benefits. Recent work favours early diagnosis and treatment, and there has been increasing effort to treat children as soon as possible. There is also renewed interest in the treatment of adults. This article reviews these areas.
Must Doctors Become Genetic Counselors?
Authors: Corinna Nelson
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Must Doctors Become Genetic Counselors? Get access Corinna Nelson Corinna Nelson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Pages 1574–1576, https://doi.org/10.1093/jnci/86.21.1574 Published: 02 November 1994
Accuracy of Screening Methods for the Diagnosis of Breast Disease
Authors: I. G. Furnival, H. J. Stewart, J. M. Weddell, P. Dovey, I. H. Gravelle, K. T. Evans, A. P. M. Forrest
Journal: BMJ (1970)

Clinical examination, thermography, and 70-mm. mammography were performed in 891 patients—414 presented to hospital with symptoms of breast disease and 477 were asymptomatic. Comparison of the diagnostic accuracy of these methods showed that neither thermography nor 70-mm. mammography has a useful place as an isolated screening procedure for breast cancer. In fact, we consider such a policy dangerous.
Controlled trial of mobilisation and manipulation for low back pain: hospital patients.
Authors: H Sims-Williams, M I Jayson, S M Young, H Baddeley, E Collins
Journal: BMJ (1979)

Ninety-four patients with non-specific lumbar pain referred to hospital rheumatology and orthopaedic clinics participated in a double-blind controlled trial comparing mobilisation and manipulation with placebo physiotherapy. Results were assessed immediately after the tratment course, two months later, and at one year. Many patients showed improvement, but in contrast to a study on general-practitioner patients with nonspecific back pain no definite advantage could be associated with mobilisation and manipulation. The benefits of mobilisation and manipulation for low back pain are probably restricted to hastening recovery in patients likely rapidly to improve spontaneously. Hence patients whose severity and duration of symptoms warrant specialist referral are less likely to benefit from the technique.
Myocardial Infarction Site and Mortality in Diabetes
Authors: Simon Weitzman, Galen S Wagner, Gerardo Heiss, Thomas L Haney, Cecil Slome
Journal: Diabetes Care (1982)

Survival after a first myocardial infarction (MI) was examined in 54 diabetic and 270 nondiabetic subjects according to anatomic site of MI. Complete survival status information was obtained during a 12-yr follow-up. Compared with nondiabetic subjects, diabetics had a higher proportion of anterior site of MI below the age of 60 in both sexes. A significantly higher mortality was experienced in both sexes by patients with anterior MIs compared with other infarction sites (47% vs. 13% respectively, over 12 yr of follow-up). This excess fatality was differentially distributed by diabetic status. The 60-day mortality following admission with an anterior MI was significantly higher in diabetic (55%) than in nondiabetic subjects (31%). No differences in 60-day survival were found between diabetic and nondiabetic subjects with other infarction sites. Thus, anterior size and diabetic status each convey an increased risk of early postinfarct mortality. The findings from this study suggest that the presence of both is synergistic with regard to the 60-day mortality rate.