tbuckley/cabot-search huggingface dataset:
Reply to Giuseppe Brisinda, Serafino Vanella and Giorgio Maria's Letter to the Editor re: Athanassios Oeconomou, Helmut Madersbacher, Gustav Kiss, Thomas J. Berger, Michael Melekos and Peter Rehder. Is Botulinum Neurotoxin Type A (BoNT-A) a Novel Therapy for Lower Urinary Tract Symptoms Due to Benign Prostatic Enlargement? A Review of the Literature. Eur Urol 2008;54:765–77
Authors: Athanassios Oeconomou, Michael Melekos, Helmut Madersbacher
Journal: European Urology (2009)
Peritoneoscopy in Abdominal Emergencies - A Valuable Diagnostic Tool
Authors: E. Sundal, K. Gyr, H. Fahrlaender
Journal: Endoscopy (1982)

During the past 15 years, 343 out of a total of 5015 laparoscopies were performed as emergency procedures at our university hospital. Suspected peritonitis was the indication in 164 patients, and blunt abdominal trauma, with and without suspicion of intraabdominal bleeding, in 179 patients. Correct diagnosis was achieved in 92.7 % and 98.8 % respectively. No complications were observed. Peritoneoscopy is a very accurate diagnostic tool when applied in such situations.
Cycling of Inspiratory and Expiratory Muscle Groups with the Ventilator in Airflow Limitation
Authors: SAIRAM PARTHASARATHY, AMAL JUBRAN, MARTIN J. TOBIN
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Research on patient-ventilator interactions has largely focused on inspiratory events, with little attention paid to expiration. We sought to determine the importance of the timing and magnitude of expiratory muscle activity in causing patient-ventilator dyssynchrony. Our study was done with healthy subjects receiving pressure support in whom we induced airflow limitation with a Starling resistor. The timing and magnitude of expiratory muscle activity were obtained by wire electromyographic recording of the activity of the transversus abdominis muscle, and were compared with the cycling of the ventilator and inspiratory muscle activity as determined from a flow tracing and diaphragmatic electromyogram (EMG), respectively. Induction of airflow limitation produced significant phase differences in the cycling of the subjects' expiratory muscle group and that of the machine. Some inspiratory efforts failed to trigger the ventilator, owing in part to an increase in elastic recoil consequent to the commencement of expiratory efforts before the termination of mechanical inflation. A delay in relaxation of the expiratory muscles did not interfere with the success of subsequent inspiratory efforts to trigger the ventilator. We also investigated the accuracy of two approaches for distinguishing between the contributions of expiratory muscle activity and elastic recoil to intrinsic positive end-expiratory pressure (PEEPi): the expiratory increase in gastric pressure (Pga) correlated better with transversus abdominis electromyographic activity (r = 0.7 to 0.95) than did the early inspiratory decrease in Pga (r = 0.04 to 0.53). In conclusion, the continuation of mechanical inflation into neural expiration was associated with failure of the subsequent inspiratory attempt to trigger the ventilator.
ENZYMES OF THE GLYCOLYTIC PATHWAY IN SKIN.
Authors: P. D. MIER, D. W. K. COTTON
Journal: British Journal of Dermatology (1970)

Journal Article ENZYMES OF THE GLYCOLYTIC PATHWAY IN SKIN: XII. LACTIC DEHYDROGENASE Get access P. D. MIER, P. D. MIER The Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar D. W. K. COTTON D. W. K. COTTON The Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 3, 1 March 1970, Pages 256–260, https://doi.org/10.1111/j.1365-2133.1970.tb12434.x Published: 01 March 1970 Article history Accepted: 16 June 1969 Published: 01 March 1970
TREATMENT OF UTERINE FIBROIDS ERGOT.
Authors: FRANKLIN H. MARTIN
Journal: JAMA (1896)

<i>The physiologic actions</i>of ergot are accounted for by its effects upon unstriped muscular fiber. It contracts blood vessels everywhere, thereby increasing the blood tension. The uterus, formed as it is by an enormous proportion of smooth muscular structure, is particularly susceptible to the peculiar action of ergot. It acts upon the uterus in four ways: 1. It decreases the whole bulk of the organ by producing a steady tonic contraction of all its muscular fibers; 2, it decreases the whole bulk of the organ by decreasing the amount of blood in its walls, as a result of contracting its blood vessels; 3, by decreasing the amount of blood in the uterus (by contracting its muscular bulk and by contracting its blood vessels) it modifies materially its nutrition and decreases the amount of the menstrual flow of blood; 4, when given in large doses it not only produces tonic contractions
A nonimmunosuppressive helper virus allows high efficiency induction of B cell lymphomas by reticuloendotheliosis virus strain T.
Authors: C F Barth, E H Humphries
Journal: The Journal of Experimental Medicine (1988)

We have documented the effect of two nondefective helper viruses, reticuloendotheliosis virus A (REV-A) and chick syncytial virus (CSV) infection on bursal tissue. REV-A infection results in bursal atrophy, destroying both its structural and functional integrity. In contrast, the bursae in CSV-infected chicks, while reduced slightly in size, appear both structurally and functionally normal. REV-A-induced bursal atrophy is not a result of viral replication in the B-lymphocyte as (a) both viruses are capable of inducing, with equal efficiency, the formation of preneoplastic lesions containing proliferating B lymphocytes and (b) it appears that equivalent amounts of viral antigen are expressed in the bursae of chicks infected with either virus. We have examined the phenotype of tumors induced by the replication-defective virus REV-T when replicated by the two different helper viruses, REV-A and CSV. In REV-T(REV-A)-infected chicks, the majority of tumors that develop are negative for IgM expression. In contrast, the majority of tumors induced by REV-T(CSV) infection are IgM+. This finding is confirmed by recovery of IgM- cell lines from REV-T(REV-A)-infected chicks and IgM+ cell lines from REV-T(CSV)-infected chicks. In addition, repopulation studies show that bursal-derived cells that are IgM+ serve as target cells for REV-T(CSV)-induced lymphomas. This study demonstrates, therefore, that REV-T can induce IgM+, B cell lymphomas with high efficiency. We conclude that infections by the helper viruses, REV-A and CSV, differ dramatically in their effects on the composition of the population of cells that serve as targets for REV-T-induced neoplasia.
A Study of Diet, Blood Lipids and Vascular Disease in Trappist Monks
Authors: E. Perry McCullagh, Lena A. Lewis
Journal: New England Journal of Medicine (1960)

THE idea for this study arose when one of us (E.P. McC.) was touring with friends in New Mexico. At a monastery gate on the Pecos River a simple sign read "Order of Cistercians of the Strict Observance." We rang the bell, which was on a post by the door of the gatehouse. The door was opened by a young man dressed in a long, white robe, with a pointed cowl. He was Father Jerome, who took us in and explained that these monks lead a contemplative life, in silence, and eat no meat, fish, fowl, eggs, almost no butter . . .
Gastrointestinal Motility in Man
Authors: William P. Chapman, Stanley M. Wyman, Jacques Gagnon, Chester M. Jones, Grace L. Puleo
Journal: New England Journal of Medicine (1954)

THROUGH an error in initial instructions several tests were performed of the effect of antispasmodic drugs on gastrointestinal motility in which the subjects had taken breakfast about an hour before the administration of the medication. It was observed that the results of these tests were different from those of tests in the same subjects under standard fasting conditions. This finding, therefore, prompted us to include the administration of a standard meal in the method of assessing the effects of antispasmodic drugs on gastrointestinal motility in man. The fact that these drugs are administered therapeutically in definite relation to a feeding . . .
912 REGULATION OF THE HUMAN UDP-GLUCURONOSYLTRANSFERASE UGT1A7 BY HEPATOCYTE NUCLEAR FACTOR 1 ALPHA (HNF1 ALPHA) AND HEPATOCYTE NUCLEAR FACTOR 4 ALPHA (HNF4 ALPHA)
Authors: U. Ehmer, T.J. Erichsen, T.O. Lankisch, S. Kalthoff, N. Freiberg, M.P. Manns, C.P. Strassburg
Journal: Journal of Hepatology (2008)
Myoclonus associated with high doses of morphine
Authors: M J Glavina
Journal: BMJ (1989)

together with doxepin and amitriptyline under the heading antipsychotics, whereas the (largely D2) dopamine receptor blocking drugs thiethylperazine, metoclopramide, prochlorperazine, and domperidone appear under a separate heading of antinauseant drugs.This does not make pharmacological sense.As I see it, the point of this study is not that eight of 13 patients with side effects were taking antipsychotics and six of 13 were taking antiemetics, but rather that 12 of 12 patients with involuntary movements were taking dopamine receptor blocking drugs, which, unlike morphine, are widely recognised as a frequent cause of a wide variety of involuntary movements, including myoclonus.2Rather than concluding that "myoclonus as a side effect of treatment with morphine is more likely to occur in patients taking antidepressants or antipsychotic drugs as antiemetics or as adjuvant agents," I would pose the question, Does morphine treatment increase the likelihood of neuroleptics causing certain involuntary movements?
Abstract B24: Hepatocyte growth factor activator inhibitor type 1 (HAI-1) suppresses tumor growth and metastasis of pancreatic adenocarcinoma cells
Authors: Jing-Jia Ye, Makiko Kawaguchi, Yukihiro Haruyama, Ai Kanemaru, Tsuyoshi Fukushima, Hiroaki Kataoka
Journal: Cancer Research (2013)

Abstract Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-bound serine proteinase inhibitor expressed on epithelial and carcinoma cell surface. HAI-1 regulates hepatocyte growth factor activator, kallikrein 1-related peptidase 4 and 5 and several membrane-anchored serine proteinases such as matriptase, prostasin, hepsin, TMPRSS13 and human airway trypsin-like protease. These proteases are reported to be involved in tumor progression, and among them, matriptase and prostasin are known to activate protease-activated receptor-2 (PAR-2). Previously, we reported that S2-CP8 cells, a metastatic variant of SUIT-2 pancreatic adenocarcinoma cells, showed decreased HAI-1 expression compared to SUIT-2 and acquired EMT phenotype. To assess the HAI-1 function in metastasis of S2-CP8 cells, we established a stable S2-CP8 subline that expressed HAI-1 under control of tetracycline-regulated promoter and analyzed in a nude mouse orthotopic xenograft model. S2-CP8 cells expressed matriptase, TMPRSS13, TMPRSS4, prostasin and PAR-2. Matrigel invasion assay revealed that S2-CP8 cells showed enhanced invasion compared to SUIT-2 cells. The enhanced invasiveness was significantly suppressed by forced HAI-1 expression. Moreover, the HAI-1 loss-induced invasiveness was partly alleviated by knockdown of matriptase or PAR-2. Then, we examined the effect of HAI-1 expression on metastasis in vivo using an orthotopic xenograft model. Four weeks after the transplantation, mice were sacrificed and prepared for histological evaluation. We found that 50% of control mice developed distant metastasis. However, mice treated with tetracycline to express HAI-1 did not develop the metastasis. Though there was no difference in cell proliferation rates in vitro, tumor size was decreased by the expression of HAI-1. These results suggested that, in SUIT-2 pancreatic adenocarcinoma cell line, loss of HAI-1 enhances cell invasiveness, at least in part, through PAR-2/matriptase system in vitro, and HAI-1 plays a suppressive role in metastasis of the cells in vivo. Citation Format: Jing-Jia Ye, Makiko Kawaguchi, Yukihiro Haruyama, Ai Kanemaru, Tsuyoshi Fukushima, Hiroaki Kataoka. Hepatocyte growth factor activator inhibitor type 1 (HAI-1) suppresses tumor growth and metastasis of pancreatic adenocarcinoma cells. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr B24.
Budd–Chiari Syndrome and Factor V Leiden in a Neonate
Authors: Fiammetta Piersigilli, Cinzia Auriti, Giulio Seganti
Journal: New England Journal of Medicine (2006)

P values were obtained with the use of a two-sided Fisher's exact text.Values reflect the comparison of the failure rate in the patients who received COX-2 inhibitors (between March 2004 and December 2004) with that in patients treated during the other two periods.
p300 Plays a Critical Role in Maintaining Cardiac Mitochondrial Function and Cell Survival in Postnatal Hearts
Authors: Yasuaki Nakagawa, Koichiro Kuwahara, Genzo Takemura, Masaharu Akao, Masashi Kato, Yuji Arai, Makoto Takano, Masaki Harada, Masao Murakami, Michio Nakanishi, Satoru Usami, Shinji Yasuno, Hideyuki Kinoshita, Masataka Fujiwara, Kenji Ueshima, Kazuwa Nakao
Journal: Circulation Research (2009)

It is known that the transcriptional coactivator p300 is crucially involved in the differentiation and growth of cardiac myocytes during development. However, the physiological function of p300 in the postnatal hearts remains to be characterized.We have now investigated the physiological function of p300 in adult hearts.We analyzed transgenic mice exhibiting cardiac-specific overexpression of a dominant-negative p300 mutant lacking the C/H3 domain (p300DeltaC/H3 transgenic [TG] mice). p300DeltaC/H3 significantly inhibited p300-induced activation of GATA- and myocyte enhancer factor 2-dependent promoters in cultured ventricular myocytes, and p300DeltaC/H3-TG mice showed cardiac dysfunction that was lethal by 20 weeks of age. The numbers of mitochondria in p300DeltaC/H3-TG myocytes were markedly increased, but the mitochondria were diminished in size. Moreover, cardiac mitochondrial gene expression, mitochondrial membrane potential and ATP contents were all significantly disrupted in p300DeltaC/H3-TG hearts, suggesting that mitochondrial dysfunction contributes to the progression of the observed cardiomyopathy. Transcription of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha, a master regulator of mitochondrial gene expression, and its target genes was significantly downregulated in p300DeltaC/H3-TG mice, and p300DeltaC/H3 directly repressed myocyte enhancer factor 2C-dependent PGC-1alpha promoter activity and disrupted the transcriptional activity of PGC-1alpha in cultured ventricular myocytes. In addition, myocytes showing features of autophagy were observed in p300DeltaC/H3-TG hearts.Collectively, our findings suggest that p300 is essential for the maintenance of mitochondrial integrity and for myocyte survival in the postnatal left ventricular myocardium.
Risk for British travellers of acquiring hepatitis A
Authors: R. H Behrens, M. Collins, B. Botto, J. Heptonstall
Journal: BMJ (1995)

EDITOR,--The risk of non-immune British people acquiring hepatitis A during visits to endemic areas has been calculated as 0.047% per visit.1 Current British guidelines on immunisation against hepatitis A are specific to regions—for example, protection is not considered to be necessary for travellers to Spain, Portugal, or Italy, but tourists visiting all but first class accommodation in Turkey should be protected.2

Cases of hepatitis A are routinely reported to the Public Health Laboratory Service's Communicable Diseases Surveillance Centre by laboratories in England and Wales. Information …
Chief medical officer warns that many blood transfusions are unnecessary
Authors: Lynn Eaton
Journal: BMJ (2004)

Too many unnecessary blood transfusions are being done in England, said the Department of Health's chief medical officer, Professor Liam Donaldson, when he announced his annual report for 2003 on the state of public health.

Although his main message to the general public was the continuing importance of reducing the number of smokers and of following the lead of Ireland and the United States on smoke-free public places, the take home message for doctors was the need for more careful use of what he described as the “precious …
The encapsulation of idarubicin within liposomes using the novel EDTA ion gradient method ensures improved drug retention in vitro and in vivo
Authors: Jerzy Gubernator, Grzegorz Chwastek, Mariola Korycińska, Maria Stasiuk, Grzegorz Grynkiewicz, Felicitas Lewrick, Regine Süss, Arkadiusz Kozubek
Journal: Journal of Controlled Release (2010)
The influence of diet on the quality of faecal fat in patients with and without steatorrhoea
Authors: J. P. W. Webb, A. T. James, T. D. Kellock
Journal: Gut (1963)

By the use of gas-liquid chromatography it has been shown that the quality of the faecal fat in individuals without steatorrhoea is little affected by changes in the quality of the dietary fat. Large amounts of non-dietary fatty acids have been identified in the faeces both of patients with and without steatorrhoea. These have been identified as a number of isomers of oleic acid and hydroxystearic acids, particularly 10-hydroxystearic acid.
An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis.
Authors: D B McGregor, C Partensky, J Wilbourn, J M Rice
Journal: Environmental Health Perspectives (1998)

The International Agency for Research on Cancer (IARC) Monographs program reevaluated polychlorinated dibenzo-p-dioxins and evaluated polychlorinated dibenzofurans as possible carcinogenic hazards to humans in February 1997, using the most recent epidemiologic data on exposed human populations, experimental carcinogenicity bioassays in laboratory animals, and supporting evidence on relevant mechanisms of carcinogenesis. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) was evaluated as carcinogenic to humans (IARC group 1 classification) on the basis of limited evidence of carcinogenicity to humans derived from follow-up of workers who had been heavily exposed in industrial accidents and sufficient evidence of carcinogenicity in experimental animals. The evaluation also considered the following supporting evidence: TCDD is a multisite carcinogen in experimental animals and has been shown by several lines of evidence to act through a mechanism involving the aryl hydrocarbon receptor; this receptor is highly conserved in an evolutionary sense and functions the same way in humans as in experimental animals; tissue concentrations of TCDD are similar in heavily exposed human populations in which an increased overall cancer risk was observed and in exposed rats that developed tumors in carcinogenicity tests. Other polychlorinated dibenzo-p-dioxins, the nonchlorinated dibenzo-p-dioxin, and polychlorinated dibenzofurans were evaluated as not classifiable as to their carcinogenicity to humans (group 3).
Facteurs affectifs et facteurs rationnels dans le processus psychothérapique
Authors: Claude Bloch
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 Facteurs affectifs et facteurs rationnels dans le processus psychothérapique Subject Area: Psychiatry and Psychology Claude Bloch Claude Bloch Université Libre de Bruxelles, Bruxelles Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 168–173. https://doi.org/10.1159/000287121 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Claude Bloch; Facteurs affectifs et facteurs rationnels dans le processus psychothérapique. Psychother Psychosom 31 December 1978; 29 (1-4): 168–173. https://doi.org/10.1159/000287121 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
SIROLIMUS ELUTING- VS. PACLITAXEL ELUTING STENT IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION AND RENAL INSUFFICIENCY UNDERGOING PRIMARY ANGIOPLASTY
Authors: Sang-Ho Jo, Young-Jin Choi, Hyun-Sook Kim, Sung-Ae Kim, Chong-Yun Rhim, Kyu Rok Han
Journal: Journal of the American College of Cardiology (2010)
Learning the hard way
Authors: B. Finlayson
Journal: BMJ (2000)

I have been a keen motorcyclist for as long as I can remember. I passed my motorcycle test at the first attempt at the age of 17. I believe I am a very safe rider (don't we all?), and I ride defensively. Until this event I had never been in a situation that caused me alarm, nor had I been even close to an accident.

I was negotiating a roundabout close to a United States air base and saw a huge American left hand drive four wheel vehicle with Mafia-style tinted windows waiting to enter the traffic. I had almost made it to my exit, when the driver pulled out sharply. Everything went into slow motion as the inevitable collision occurred. I saw the kerb and the road coming to meet me, and struck my helmet as I landed. I felt the left side of my chest hit the road and the kerb as I slid along, still astride the machine. I felt so helpless, but can clearly remember thinking as I came to a halt that I could still …