Clinical Epidemiology
Authors: ALVAN R. FEINSTEIN
Journal: Annals of Internal Medicine (1968)

Special Article1 December 1968Clinical EpidemiologyIII. The Clinical Design of Statistics in TherapyALVAN R. FEINSTEIN, M.D., F.A.C.P.ALVAN R. FEINSTEIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-6-1287 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOUTLINE OF CONTENTS: PART IIIINTRODUCTIONPROGNOSTIC DISTINCTIONSINDEX OF ACCOMPLISHMENTCORRELATED PROGNOSTIC STRATIFICATIONTHE ASSESSMENT OF CO-MORBIDITYPOPULATIONAL TRANSFERSINVESTIGATOR'S CHOICE OF TEMPORAL DEMARCATIONSDECISIONS MADE BY PATIENTS AND DOCTORSTAXONOMIC LOGISTICSNONCLINICAL PRINCIPLES"CONTROL" TREATMENTDOUBLE-BLIND TECHNIQUERANDOM ALLOCATIONSUMMARYINTRODUCTIONPerhaps the most striking intellectual change in modern treatment has been its frequent conversion from an act of clinical medicine to an act of statistics.Reports that lack appropriate statistical analysis will regularly be rejected today by the editors of leading medical journals; various papers in contemporary medical literature recurrently provide instructive discussions of statistical principles useful...References1. 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Author, Article, and Disclosure InformationAffiliations: New Haven, ConnecticutFrom the Eastern Research Support Center and the Department of Medicine, West Haven Veterans Administration Hospital, West Haven; and the Departments of Medicine and Epidemiology, Yale University School of Medicine, New Haven; Conn.This study was supported in part by grant 13977-03-68-06, Department of Health, Education, and Welfare, U. S. Public Health Service Cancer Control Program, Washington, D. C.Requests for reprints should be addressed to Alvan R. 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