Gluten and the Pathogenesis of Celiac Disease
Authors: GRAHAM H. JEFFRIES
Journal: Annals of Internal Medicine (1964)

Editorials1 April 1964Gluten and the Pathogenesis of Celiac DiseaseGRAHAM H. JEFFRIES, M.B., M.R.C.P., MARVIN H. SLEISENGER, M.D., F.A.C.P.GRAHAM H. JEFFRIES, M.B., M.R.C.P.Search for more papers by this author, MARVIN H. SLEISENGER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-705 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been the universal experience of clinicians treating childhood and adult celiac disease that withdrawal of the cereal protein, gluten, from the diet may induce a clinical remission. Many recent reports describe the changes in intestinal histology and in absorptive function that result from this dietotherapy. In this issue of the ANNALS OF INTERNAL MEDICINE on page 581, Bolt, Parrish, French, and Pollard record the results of therapy in 13 patients. Their experience corresponds to that of other groups who have studied this disease (1-6).The development of techniques forper oralbiopsy of the small intestinal mucosa has...References1. ANDERSON CM: Histological changes in the duodenal mucosa in celiac disease—reversibility during treatment with a wheat gluten-free diet. Arch. Dis. Child. 35: 419, 1960. CrossrefMedlineGoogle Scholar2. RUBIN CE: Celiac disease and idiopathic sprue: some reflections on reversibility, gluten and the intestine. Gastroenterology 39: 260, 1960. MedlineGoogle Scholar3. ASHWORTHCHEARS CTWC: Follow-up of intestinal biopsy in non-tropical sprue after gluten-free diet and remission. Fed. Proc. 21: 880, 1962. MedlineGoogle Scholar4. YARDLEYBAYLESSNORTONHENDRIX JMTMJHTR: Celiac disease: a study of the jejunal epithelium before and after gluten-free diet. New Eng. J. Med. 267: 1173, 1962. CrossrefMedlineGoogle Scholar5. COOKEFONECOXMEYNELLGADDIE WTDJEVMJR: Adult celiac disease. Gut 4: 279, 1963. CrossrefMedlineGoogle Scholar6. BENSONKOWLESSARSLEISENGER GDODMH: Adult celiac disease: with emphasis upon response to the gluten-free diet. Medicine 43: 1, 1964. CrossrefMedlineGoogle Scholar7. RUBINBRANDBORGPHELPSTAYLOR CELLPCHC: Studies of celiac disease. 1. The apparent identical and specific nature of the duodenal and proximal jejunum lesion on celiac disease and idiopathic sprue. Gastroenterology 38: 28, 1960. CrossrefMedlineGoogle Scholar8. RUBIN CE: Malabsorption: celiac sprue. Ann. Rev. Med. 12: 39, 1961. CrossrefMedlineGoogle Scholar9. HOLMESHOURIHANEBOOTH RDOCC: Dissecting-microscope appearances of jejunal biopsy specimens from patients with idiopathic steatorrhea. Lancet 1: 81, 1961. CrossrefMedlineGoogle Scholar10. RUBINBRANDBORGFLICKPHELPSPARMENTIERVAN NIEL CELLALPCS: Studies in celiac sprue. III. The effect of repeated wheat instillation into the proximal ileum of patients on gluten free diet. Gastroenterology 43: 621, 1962. CrossrefMedlineGoogle Scholar11. GOUGHREADNAISH KRAEJM: Intestinal reticulosis as a complication of idiopathic steatorrhea. Gut 3: 232, 1962. CrossrefMedlineGoogle Scholar12. WEIJERSVAN DE KAMER HAJH: Some biochemical investigations into the cause of wheat sensitivity in celiac disease, in Proceedings of the World Congress of Gastroenterology, 1958, Washington, D. C. The Williams & Wilkins Company, Baltimore, Maryland, 1959, p. 578. Google Scholar13. KRAINICKMOHN HGG: Further investigations on the toxic effect of wheat flour in celiac disease. II. Effect of the enzymatic by-products of gliadin. Helv. Paediat. Acta 14: 124, 1959. MedlineGoogle Scholar14. FRAZERFLETCHERROSSSHAWSAMMONSSCHNEIDER ACRFCABHGR: Gluten-induced enteropathy. The effect of partially digested gluten. Lancet 2: 252, 1959. CrossrefMedlineGoogle Scholar15. KOWLESSARWESERHAEFFNER ODELJ: Abnormal rise of plasma amino acids and the appearance of a polypeptide in the plasma in adult celiac disease after oral administration of gliadin (abstract). J. Clin. Invest. 41: 1374, 1962. Google Scholar16. HEINERLAHEYWILSONGERRARDSHWACHMANKHAW DCMEJFJWHK: Precipitins to antigens of wheat and cow's milk in celiac disease. J. Pediatrics 61: 813, 1962. CrossrefGoogle Scholar17. TAYLORTHOMSONTRUELOVEWRIGHT KBDLSCR: An immunologic study of coeliac disease and idiopathic steatorrhea. Brit. Med. J. 2: 1727, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GRAHAM H. JEFFRIES, M.B., M.R.C.P.; MARVIN H. SLEISENGER, M.D., F.A.C.P.Affiliations: New York Hospital-Cornell Medical Center New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGluten antibodies and tropical sprueSelective IgA deficiency with steatorrhea 1 April 1964Volume 60, Issue 4 Page: 705-708 Keywords Biopsy Celiac disease Diet Gluten Histology Mucous membranes Pathogenesis ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...