Prothrombin Complex Preparations: A Cautionary Note
Authors: OSCAR D. RATNOFF
Journal: Annals of Internal Medicine (1974)

Editorial Notes1 December 1974Prothrombin Complex Preparations: A Cautionary NoteOSCAR D. RATNOFF, M.D.OSCAR D. RATNOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-6-852 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe successful use of concentrates of human plasma rich in antihemophilic factor (factor VIII) in the treatment of classic hemophilia and von Willebrand's disease has encouraged the hope that analagous preparations of the vitamin K-dependent clotting factors might be helpful in the care of the much larger group of patients with deficiencies of one or more of the components of the so-called prothrombin complex. A striking property shared by the four recognized vitamin K-dependent clotting factors—Christmas factor (factor IX), factor VII, Stuart factor (factor X), and prothrombin (factor II)—is their adsorption onto certain insoluble salts, for example, barium sulfate or...References1. OKENHOOTKINDEJAGER MLR: Hepatitis after Konȳne administration. Am J Dig Dis 17:271-274, 1972 CrossrefMedlineGoogle Scholar2. SANDLERRATHWICKERHAUSER SCM: Post-Konȳne hepatitis: the ineffectiveness of screening for the hepatitis B antigen (HG Ag). Transfusion 13:221-224, 1973 CrossrefMedlineGoogle Scholar3. GRAMMENSBRECKENRIDGE GR: Complications with Christmas factor (factor IX) concentrates (letter). Ann Intern Med 80:666-667, 1974 LinkGoogle Scholar4. EDELL S: Anaphylaxis after Konȳne (letter). N Engl J Med 285:580, 1971 CrossrefMedlineGoogle Scholar5. BLATTLUNDBLADKINGDON PRH: Thrombogenic materials in prothrombin complex concentrates. Ann Intern Med 81:766-770, 1974 LinkGoogle Scholar6. BREENTULLIS FJ: Prothrombin concentrates in treatment of Christmas disease and allied disorders. JAMA 208:1848-1852, 1969 CrossrefMedlineGoogle Scholar7. BLATRIXSOULIER CJ: Préparation d'une fraction riche en prothrombine, proconvertine, facteur Stuart et facteur anti-hémophilique B (fraction P.P.B.). Pathol et Biol 7:2477-2486, 1959 MedlineGoogle Scholar8. BIDWELLBOOTHDIKE EJG: The preparation for therapeutic use of a concentrate of factor IX containing also factors II, VII and X. Br J Haemat 13:568-580, 1967 CrossrefMedlineGoogle Scholar9. MENACHE D: Utilisation en hépatologie d'une fraction contenant la prothrombine, le complex proconvertine-facteur Stuart et le facteur anti-hémophilique B (P.P.B.). Pathol et Biol 7:2515-2523, 1959 Google Scholar10. TULLISMELINJURGIAN JMP: Clinical use of human prothrombin complexes. N Engl J Med 273:667-674, 1965 CrossrefMedlineGoogle Scholar11. EDSON J: Prothrombin-complex concentrates and thromboses (letter). N Engl J Med 290:403, 1974 CrossrefMedlineGoogle Scholar12. MARCHESIBURNEY SR: Prothrombin-complex concentrates and thromboses (letter). N Engl J Med 290:403-404, 1974 CrossrefMedlineGoogle Scholar13. CEDARBAUMROBERTS AH: Complications of the use of prothrombin complex concentrates in liver disease (abstract). Clin Res 21:92, 1973 Google Scholar14. LOELIGERHENSENMATTERN EAM: Treatment of haemophilia B with purified factor IX (PPSB). Folia Med Neerl 10:112-125, 1967 MedlineGoogle Scholar15. KASPER C: Postoperative thromboses in hemophilia B (letter). N Engl J Med 289:160, 1974 Google Scholar16. STEINBERGDREILING MB: Vascular lesions in hemophilia B (letter). N Engl J Med 289:592, 1974 Google Scholar17. WESSLER S: Studies in intravascular coagulation. III. The pathogenesis of serum-induced venous thrombosis. J Clin Invest 34:647-651, 1955 CrossrefMedlineGoogle Scholar18. WESSLERYIN SE: Experimental hypercoagulable state induced by factor X: comparison of the nonactivated and activated forms. J Lab Clin Med 72:256-260, 1968 MedlineGoogle Scholar19. BOTTIRATNOFF RO: Studies on the pathogenesis of thrombosis: an experimental "hypercoagulable" state induced by the intravenous injection of ellagic acid. J Lab Clin Med 64:385-398, 1964 MedlineGoogle Scholar20. ARONSON D: Inhibition of thrombotic effect of factor IX (letter). N Engl J Med 290:861, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Case Western Reserve University School of Medicine University Hospitals of Cleveland Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFirst 20 years with recombinant FVIIa (NovoSeven)Trauma and oral anticoagulantsAntihemophilic Factor 1 December 1974Volume 81, Issue 6Page: 852-853KeywordsBlood plasmaHemophilia ASaltsSulfatesvon Willebrand disease Issue Published: 1 December 1974 PDF DownloadLoading ...