tbuckley/cabot-search huggingface dataset:
DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells
Authors: Zhiqiang Zhang, Taeil Kim, Musheng Bao, Valeria Facchinetti, Sung Yun Jung, Amir Ali Ghaffari, Jun Qin, Genhong Cheng, Yong-Jun Liu
Journal: Immunity (2011)
Possible reversed affective lateralization in a case of bipolar disorder
Authors: H A Sackeim, P Decina, D Epstein, G E Bruder, S Malitz
Journal: American Journal of Psychiatry (1983)

A right-handed 42-year-old man with bipolar II disorder according to the Research Diagnostic Criteria was tested during two depressive phases, a hypomanic phase, and after a series of left ECT treatments. While drug free he was given a set of tasks sensitive to asymmetry in hemispheric activation. The results indicated hyperactivation of the right hemisphere during the hypomanic episode and of the left hemisphere during the depressive episodes. After left ECT, the patient evidenced greater symmetry. The authors suggest that this case is an instance of reversed lateralization in the regulation of positive and negative mood states.
Colonic endoscopic submucosal dissection using a flexible Maryland dissector
Authors: D. von Renteln, H. Pohl, M. Vassiliou, R. Rothstein
Journal: Endoscopy (2009)

Endoscopic resection of T1N0 gastrointestinal malignancies has shown excellent long-term recurrence-free and overall survival rates when tumor-free resection margins are achieved [1] [2]. For en bloc resection of lesions larger than 20 mm, piecemeal resection or endoscopic submucosal dissection (ESD) is required [3]. Although many different devices are available, ESD remains technically difficult, time consuming, and associated with perforation rates of up to 10 % [1] [2] [4] [5]. The laparoscopic Maryland dissector is a standard surgical instrument used for fine dissection. A flexible version of this instrument that can be passed through a 3.7-mm endoscopic working channel has recently become available ([Video 1]).
Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor β/δ regulates vascular permeability and anaphylaxis
Authors: Marta Wawrzyniak, Christine Pich, Barbara Gross, Frédéric Schütz, Sébastien Fleury, Sandrine Quemener, Marie Sgandurra, Emmanuel Bouchaert, Catherine Moret, Lionel Mury, Corinne Rommens, Hélène Mottaz, David Dombrowicz, Liliane Michalik
Journal: Journal of Allergy and Clinical Immunology (2014)
Molecular Heterogeneity of Inherited Antithrombin III Deficiency
Authors: Edward V. Prochownik, Stylianos Antonarakis, Kenneth A. Bauer, Robert D. Rosenberg, Eric R. Fearon, Stuart H. Orkin
Journal: New England Journal of Medicine (1983)

Inherited antithrombin III deficiency is associated with an increased risk of thromboembolism. Using recombinant-DNA techniques, we isolated a molecular probe for the antithrombin III structural gene and identified a common DNA polymorphism within the gene. We found that there is genetic heterogeneity in this disorder. In one family, the antithrombin III gene was deleted in affected members, whereas in another no deletion occurred. Use of the DNA polymorphism should allow identification and further characterization of abnormal antithrombin III genes.
Lymphocyte sensitivity to human skeletal muscle antigen in polymyositis.
Authors: M M Esiri, B L Hazleman, I C MacLennan
Journal: Annals of the Rheumatic Diseases (1973)

between the patient groups were demonstrated.The results may influence the surgical management of these patients.Discussion PROF .V. WRIGHT (Leeds) I am interested to know how you determine when the wound is healed.DR.MOWAT We did not find this in the medical notes but on looking carefully through the nursing notes we found enough information.MR. S. J. BURROUGH (Stoke Mandeville) What significance doyouattach to separation ?Is a separatedwound a delayed healing wound as far as you are concerned?DR.MOWAT It is a delayed healing wound, but we have assessed independently those that were infected and those that were just simply separated with the wound-edge gaping.
DIET AND TISSUE GROWTH
Authors: Theodore S. Moise, Arthur H. Smith
Journal: The Journal of Experimental Medicine (1924)

1. The toxicity of chloroform varies according to the diets used in these experiments in the following order of decreasing susceptibility of the animals: high fat > standard > high carbohydrate > high protein diets. 2. On the high fat and high carbohydrate diets there may be a more or less marked proliferation of the endothelium and the connective tissue stroma in the necrotic area producing in some instances scars resembling the picture of an early cirrhosis. 3. On the diets studied, standard, high carbohydrate, high protein, and high fat, the most active and rapid repair is observed on the standard balanced diet. On the high fat diet the reparative process is definitely delayed in comparison with the others. There are only slight differences between the high carbohydrate and high protein diets which suggest but do not conclusively show a more rapid repair with the latter diet.
Fenfluramine: riddle or Rosetta stone?
Authors: E. K. Weir, M. Obreztchikova, Z. Hong
Journal: European Respiratory Journal (2008)

Idiopathic pulmonary arterial hypertension (IPAH) used to be called primary pulmonary hypertension. Both terms indicate that we do not yet fully understand the aetiology of the disease. A clue to the underlying mechanisms lies in the observation that the appetite-suppressant drugs aminorex 1, 2 and fenfluramine 3 were both associated with a marked increase in the incidence of pulmonary arterial hypertension (PAH) while they were available in Europe. Although they are no longer prescribed, it is important to study them to gain an understanding of IPAH and to ensure that new drugs do not have the potential to cause pulmonary hypertension. In general, there is no clinical or pathological way to distinguish PAH associated with these anorectic agents from IPAH independent of them. This point is clearly made in a study by Souza et al. 4 in the present issue of the European Respiratory Journal . Souza et al. 4 describe the follow-up of 109 patients diagnosed with PAH in association with exposure to fenfluramine between 1986 and 2004. In virtually every respect, the presentation and clinical course of these patients was the same as that of patients with IPAH who were diagnosed over the same period. Interestingly, 18% of the fenfluramine PAH patients had a bone morphogenic protein receptor 2 (BMPR2) gene mutation, a very similar incidence to that observed in sporadic IPAH 5. This suggests the likelihood of underlying genetic susceptibility that renders both groups vulnerable, perhaps to a similar second hit.

There is one marked difference in the spectrum of disease caused by fenfluramine and that seen in IPAH. Although fenfluramine was recognised to cause PAH it was actually withdrawn from the market in 1997 because of an associated cardiac valvulopathy 6. The valvulopathy does not occur in IPAH but resembles that seen in …
Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in mice
Authors: Pietro E. Cippà, Sarah S. Gabriel, Jin Chen, Philip D. Bardwell, Andrew Bushell, Annick Guimezanes, Anna K. Kraus, Thomas Wekerle, Rudolf P. Wüthrich, Thomas Fehr
Journal: Blood (2013)
Ga-67 Scintigraphy in Pediatric Patients
Authors: TOM X.-L. TAN, MICHAEL J. GELFAND
Journal: Clinical Nuclear Medicine (1996)

Ga-67 SPECT has been shown to be more sensitive than planar imaging in several pediatric and adult studies. With multidetector SPECT cameras, SPECT imaging of multiple sites and volumes rendered images are possible. This study was performed to determine if SPECT of the chest, abdomen, and pelvis can be substituted for planar imaging of the same body regions. Fifty-one Ga-67 studies in 36 patients with lymphoma (29 patients) and inflammation (7 patients) were reviewed. Ga-67 SPECT of the chest, abdomen, and pelvis was compared with planar images of the same body regions. There were 52 abnormal sites on SPECT and 42 on planar imaging. Ten sites were positive only on SPECT; five of these sites were seen on SPECT because of improved three-dimensional separation of sites of gallium uptake. In the limited number of cases in this study, duplicate planar and SPECT imaging of the same volume was unnecessary.
Rubella in Pregnancy: A Guide to Rational Counseling
Authors: Vincent A. Fulginiti
Journal: JAMA (1981)

In an article elsewhere in this issue (p 1647), Mann and colleagues have made an important addition to our ability to analyze and advise on the risk of congenital rubella after a possible exposure of a pregnant woman to an illnesswith rash. In one sense they are helping to ease the congestion of the national telephone lines, as many physicians in this dilemma call their favorite rubella experts (often at medical schools or at the Centers for Disease Control) for some help in estimating the probabilities of an adverse outcome. The method Mann et al have chosen is the preparation of three algorithms that speak to commonly encountered situations. The three algorithms deal with three periods between exposure to illness -with rash and the time of assessment—within one week, one to five weeks, and greater than five weeks—and the interpretation of the available standard laboratory test results. They also
Information for patients: Getting professional help
Authors: Z. Kmietowicz
Journal: BMJ (2003)

Yes. Getting advice, counselling, and support from a doctor, nurse, or trained counsellor can help you quit smoking. Pregnant women who smoke and smokers who are admitted to the hospital are especially likely to benefit from advice and counselling. Your doctor, nurse, or counsellor may suggest that you quit smoking, explain why, and give you a few tips on how to do it. Or you may take part in group sessions that are part of a stop-smoking programme. There are many different types of counselling. Here are some examples of what counselling can mean:
Landmark perspective: Penicillin and early syphilis
Authors: H. L. Arnold
Journal: JAMA (1984)

<h3>Early Therapy for Syphilis</h3> Paul Ehrlich's dream of the therapia magna sterilisans for early syphilis — destroying the spirochetes en masse with a single intravenous (IV) injection of arsphenamine, the 606th compound he designed and tried for this purpose — seemed in 1912 to have been realized, but it was not. Patients treated in this way relapsed by the hundreds, and dermatologists — practitioners of the specialty that still treated most cases of syphilis in those years because the diagnosis had to be made dermatologically and only confirmed serologically — learned by many failures that (1) heavy metals (mercury or, later, bismuth) had to be alternated with the arsenic and (2) therapy, unless prolonged for a minimum of two or three years, achieved only temporary success. The complexity of syphilotherapy and its simplification by penicillin are perhaps most dramatically illustrated by the space required to describe the treatment of syphilis
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Authors: Alexander Zimprich, Saskia Biskup, Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne, A.Jon Stoessl, Ronald F. Pfeiffer, Nadja Patenge, Iria Carballo Carbajal, Peter Vieregge, Friedrich Asmus, Bertram Müller-Myhsok, Dennis W. Dickson, Thomas Meitinger, Tim M. Strom, Zbigniew K. Wszolek, Thomas Gasser
Journal: Neuron (2004)
Prophylactic infusion of cytomegalovirus-specific cytotoxic T lymphocytes stimulated with Ad5f35pp65 gene-modified dendritic cells after allogeneic hemopoietic stem cell transplantation
Authors: Kenneth P. Micklethwaite, Leighton Clancy, Upinder Sandher, Anna M. Hansen, Emily Blyth, Vicki Antonenas, Mary M. Sartor, Kenneth F. Bradstock, David J. Gottlieb
Journal: Blood (2008)
Forty Years of Full-Time Medicine at University of Chicago
Authors: Henry T. Ricketts
Journal: JAMA (1969)

It is common knowledge that for the past two decades or more there has been a steady increase in the number of full-time clinical positions in the medical schools and hospitals of this country. The conditions governing these positions, however, have varied widely. In most cases the schoolrelated hospital provides an office from which the physician emerges to perform his duties as clinical teacher, but in which, or in other quarters of the building, he is permitted to see private patients on a fee-for-service basis. In such cases, an accommodation is reached between the amount of his salary and the amount of his income derived from patients. There are various formulas, based on temporal or fiscal criteria or both, for limiting the activities in the private practice of medicine or surgery. What has just been described is known as "geographic full time." It is distinguished from true full time, in
Endoscopic features of intestinal follicular lymphoma: the value of double-balloon enteroscopy
Authors: S. Nakamura, T. Matsumoto, J. Umeno, S. Yanai, Y. Shono, H. Suekane, M. Hirahashi, T. Yao, M. Iida
Journal: Endoscopy (2007)

Intestinal follicular lymphoma is uncommon, and its endoscopic appearance has seldom been described [1] [2] [3] [4]. We report five patients with primary intestinal follicular lymphoma in whom the whole of the gastrointestinal tract were examined using esophagogastroduodenoscopy (EGD), colonoscopy, and double-balloon enteroscopy [5].
A case of reticular erythematous mucinosis treated with topical tacrolimus
Authors: P. Rubegni, P. Sbano, M. Risulo, S. Poggiali, M. Fimiani
Journal: British Journal of Dermatology (2004)

Journal Article A case of reticular erythematous mucinosis treated with topical tacrolimus Get access P. Rubegni, P. Rubegni Department of Clinical Medicine and Immunology, Section of Dermatology, University of Siena, Policlinico 'Le Scotte', 53100 Siena, Italy E‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar P. Sbano, P. Sbano Department of Clinical Medicine and Immunology, Section of Dermatology, University of Siena, Policlinico 'Le Scotte', 53100 Siena, Italy E‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar M. Risulo, M. Risulo Department of Clinical Medicine and Immunology, Section of Dermatology, University of Siena, Policlinico 'Le Scotte', 53100 Siena, Italy E‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar S. Poggiali, S. Poggiali Department of Clinical Medicine and Immunology, Section of Dermatology, University of Siena, Policlinico 'Le Scotte', 53100 Siena, Italy E‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar M. Fimiani M. Fimiani Department of Clinical Medicine and Immunology, Section of Dermatology, University of Siena, Policlinico 'Le Scotte', 53100 Siena, Italy E‐mail: rubegni@unisi.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 1, 1 January 2004, Pages 173–174, https://doi.org/10.1111/j.1365-2133.2004.05718.x Published: 01 January 2004
Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level.
Authors: S Marshall, J M Olefsky
Journal: Journal of Clinical Investigation (1980)

We have examined the effect of in vitro hyperinsulinemia on insulin binding, glucose transport, and insulin degradation in isolated rat adipocytes. When cells were incubated with insulin for 2 or 4 h at 37 degrees C, followed by washing in insulin-free buffer to remove extracellular and receptor-bound insulin, a time and dose-dependent decrease in insulin receptors was observed, which was accompanied by a reduced ability of cells to degrade insulin. Furthermore, the quantitatively predicted rightward shift in the insulin-glucose transport dose-response curve could be demonstrated. In addition to this reduction in insulin sensitivity, a striking decrease in maximal insulin-stimulated glucose transport was observed in the 4-h insulin-treated cells, indicating an abnormality distal to the insulin receptor. Thus, in vitro insulin-induced insulin resistance in adipocytes is caused by both receptor and postreceptor abnormalities. The post-receptor defect is most likely at the level of the glucose transport system per se because the insulinlike agents, spermine and antiinsulin receptor antibodies, also had a markedly reduced ability to stimulate glucose transport in 4-h insulin-treated cells. On the other hand, when cells were incubated with 100 ng/ml insulin for up to 4 h, after which time 2-deoxy glucose uptake was measured without removing buffer insulin or allowing receptor-bound insulin to dissociate, no decrease in maximal insulin-stimulated glucose transport was found. In conclusion, (a) insulin leads to a dose-dependent loss of insulin receptors in freshly isolated adipocytes accompanied by the predicted functional consequence of decreased receptors, i.e., a rightward shift in the insulin-glucose transport dose-response curve, (b) prolonged incubation with insulin causes a marked postreceptor defect in the glucose transport system, (c) maintenance of the activated state of the glucose transport system prevents the expression of the post-receptor defect, (d) the location of the postreceptor abnormality is most likely in the glucose transport system per se, and (e) insulin-induced receptor loss is accompanied by a decrease in insulin degradation.
Severity of Meningococcal Disease in Children and the Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism
Authors: David Harding, Paul B. Baines, David Brull, Vassilis Vassiliou, Ian Ellis, Anthony Hart, Alistair P. J. Thomson, Steve E. Humphries, Hugh E. Montgomery
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Critical illness outcome may be causally related to inflammatory response severity. Given that tissue angiotensin-converting-enzyme (ACE) regulates such responses and that the deletion (D) [rather than insertion (I)] variant of the ACE gene is associated with higher tissue ACE levels, DD genotype might be associated with a poorer outcome in a uniform infectious disease state. Illness severity (Pediatric RIsk of Mortality score, the Glasgow Meningococcal Septicaemia Prognostic Score [GMSPS], and clinical course) was recorded for consecutive white patients with meningococcal disease (n = 110, 34 DD genotype, 61 male, aged 49.4 ± 5.4 months) referred to the Royal Liverpool Children's Hospital, UK. Compared with children with ⩾ I allele, DD genotype was associated with 14% higher predicted risk of mortality (p = 0.038), higher GMSPS (DD 9.4 ± 0.5, ID/II 7.7 ± 0.4 [mean ± SEM], p = 0.013), greater prevalence of inotropic support (76% versus 55%, p = 0.03) and ventilation (82% versus 63%, p = 0.04), and longer Pediatric Intensive Care Unit (PICU) stay (5.8 versus 3.9, p = 0.02). DD genotype frequency was 6% (1 case) for the 18 children who did not require PICU care, 33% for the 84 PICU survivors, and 45% for those who died (p = 0.01). ACE DD is associated with increased illness severity in meningococcal disease.
The Effects of KW-3902, an Adenosine A1-Receptor Antagonist,on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure and Renal Impairment or Diuretic Resistance
Authors: Michael M. Givertz, Barry M. Massie, Tara K. Fields, Leeanne L. Pearson, Howard C. Dittrich
Journal: Journal of the American College of Cardiology (2007)
Autonomic neuropathy in systemic sclerosis.
Authors: P S Klimiuk, L Taylor, R D Baker, M I Jayson
Journal: Annals of the Rheumatic Diseases (1988)

Autonomic function assessed by tests of cardiovascular reflexes was studied in 25 patients with systemic sclerosis and 10 patients with primary Raynaud's phenomenon. A comparison was made with 13 normal healthy subjects. Significant abnormalities in the cardiovascular reflexes were found in systemic sclerosis, both in the CREST (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) variant and also in those patients with diffuse involvement. There was sympathetic and parasympathetic dysfunction. These findings suggest that autonomic neuropathy is a feature of systemic sclerosis.
Superannuation and the Elderly G.P
Authors: W. Tweddell
Journal: BMJ (1973)

vaccination had readily paid £150 for a holiday for two, £10 for his Dassport, and £7 to park his car at the airport.If doctors are unble or unwilling to alter their open-ended contract with the Government, at least let there -be proper professional respect in the private sector.-I am, etc.,
CAUSES UNDERLYING INCREASED INCIDENCE OF BROAD TAPEWORM IN MAN IN NORTH AMERICA
Authors: TEUNIS VERGEER
Journal: JAMA (1930)

In a recent publication I 1 pointed out that fish-eating dogs must constitute an important reservoir of Diphyllobothrium latum Linnaeus, the broad tapeworm of man, in Canadian lake regions and that in some sparsely populated districts dogs may be the most important agents in bringing about the completion of the life cycle of this parasite and thus maintaining it by continually reinfesting nearby lakes with the eggs of the broad tapeworm.  In another recent publication I 2 reported the successful experimental infestation of two bears with the broad tapeworm. This experiment was performed because bears are common in northern lake regions where fish are infested with the larvae of this worm. Bears are known to eat fish during the spawning season in the spring when they can readily catch them. Bears, then, may also help in the reinfestation of fish with plerocercoids of the broad tapeworm by passing eggs with
Patients’ Expectations from Renal Grafting and Transplantation Outcome
Authors: Wolfgang Pommer, Peter Diederichs, Max Hummel, Peter Kratzer, Gerd Offermann, Martin Molzahn
Journal: Psychotherapy and Psychosomatics (1985)

Prevailing reports on psychological prediction of renal graft integration are rare, mostly based on case studies. Focusing on patients' expectations from the transplantation process before grafting, we investigate the influence of psychological data and statements on the final transplantation results. In the whole group (n = 83) the attitude toward transplantation was very optimistic. Comparing the features of patients with successful graft outcome (n = 23) and graft failure or patient's death (n = 10) the latter group shows: lower scale values of optimistic attitude toward transplantation outcome, higher level of fear concerning surgical treatment, less willingness to agree preoperatively to second transplantation in case of first graft failure. Psychological data indicate a greater tendency toward more submissive, rigid, and depressive behavior. It is assumed that the patient's attitude and expectation on grafting is a part of the conditions influencing the final transplantation result. Further studies should prove this concept.