Familial Type III Hyperlipoproteinemia
Authors: Robert I. Levy, Joel Morganroth
Journal: Annals of Internal Medicine (1977)

Editorials1 November 1977Familial Type III HyperlipoproteinemiaROBERT I. LEVY, M.D., JOEL MORGANROTH, M.D.ROBERT I. LEVY, M.D.Search for more papers by this author, JOEL MORGANROTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-625 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFamilial hyperlipoproteinemia was discovered through one of its secondary and inconsistent manifestations, deposits of lipids in skin and tendons, called xanthomatosis. As early as 1873, however, it was suggested that xanthomas might arise from hyperlipidemia, a supposition reinforced by histologic and chemical analyses of xanthomatous lesions in man and experiments in animals (1).Gofman and colleagues (2) laid the foundation for the study of hyperlipidemia based on lipoprotein analyses. In 1954, using analytical ultracentrifugation they provided the first clear-cut separation by lipoprotein analyses of what they then called "xanthoma tuberosum" from "xanthoma tendinosum." The patient with "xanthoma tendinosum" (now known...References1. FREDRICKSONLEVY DR: Familial hyperlipoproteinemia, in The Metabolic Basis of Inherited Disease, 3rd ed., edited by STANBURY JB, WYNGAARDEN JB, FREDRICKSON DS. New York, McGraw-Hill, 1972, pp. 545-614. Google Scholar2. GOFMANDELALLAGLAZIERFREEMANLINDGRENNICHOLSSTRISOWERTAMPLIN JOFNFAEA: The serum lipoprotein transport system in health, metabolic disorders, atherosclerosis, and coronary heart disease. Plasma 2:413-484, 1954 Google Scholar3. FREDRICKSONLEVYLEES DRR: Fat transport in lipoproteins. An integrated approach to mechanisms and disorders. N Engl J Med 276:34-44, 94-103, 148-156, 215-225, 273-281, 1967 CrossrefMedlineGoogle Scholar4. FREDRICKSONLEVYLINDGREN DRF: A comparison of heritable abnormal lipoprotein patterns as defined by two different techniques. J Clin Invest 47:2446-2457, 1968 CrossrefGoogle Scholar5. BORRIE P: Type III hyperlipoproteinemia. Br Med J 2:665-661, 1969 CrossrefMedlineGoogle Scholar6. MASKETLEVYFREDRICKSON BRD: The use of polyacrylamide gel electrophoresis in differentiating type III hyperlipoproteinemia. J Lab Clin Med 81:794-802, 1973 MedlineGoogle Scholar7. HAZZARDPORTEBIERMAN WDE: Abnormal lipid composition of very low density lipoproteins in diagnosis of broad beta disease (type III hyperlipoproteinemia). Metabolism 21:1009-1019, 1972 CrossrefMedlineGoogle Scholar8. FREDRICKSONMORGANROTHLEVY DJR: Type III hyperlipoproteinemia: An analysis of two contemporary definitions. Ann Intern Med 82:150-157, 1975 LinkGoogle Scholar9. MORGANROTHLEVYFREDRICKSON JRD: The biochemical, clinical and genetic features of type III hyperlipoproteinemia. Ann Intern Med 82:158-174, 1975 LinkGoogle Scholar10. EISENBERGLEVY SR: Lipoproteins and lipoprotein metabolism, in Hypolipidemic Agents, edited by KRITCHEVSKY D. New York, Springer-Verlag, 1975, pp. 191-213 CrossrefGoogle Scholar11. HAVELKANE RJ: Primary dysbetalipoproteinemia: predominance of a specific apoprotein species in triglyceride-rich lipoproteins. Proc Natl Acad Sci USA, 70:2015-2019, 1973 CrossrefMedlineGoogle Scholar12. CURRYMCCONATHYALAUPOVICLEDFORDPOPOVIC MWPJM: Determination of human apolipoprotein E by electroimmunoassay. Biochim Biophys Acta 439: 413-425, 1976 CrossrefMedlineGoogle Scholar13. FELKERFAINARUHAMILTONHAVEL TMRR: Secretion of the arginine-rich and A-I apolipoproteins by the isolated perfused rat liver. J Lipid Res 18:465-473, 1977 CrossrefMedlineGoogle Scholar14. MAHLEYHOLCOMBE RK: Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat. J Lipid Res 18:314-324, 1977 CrossrefMedlineGoogle Scholar15. CHAITALBERSBRUNZELLHAZZARD AJJW: Type III hyperlipoproteinemia ("Remnant removal disease"). Lancet 1: 1176-1178, 1977 CrossrefMedlineGoogle Scholar16. PHAIRHALLBILHEIMERLEVYGOEBELBERMAN RMDRRM: Modeling lipoprotein metabolism in man, in Proceedings of Summer Computer Simulation Conference, 1976, Washington, D. C. La Jolla Simulation Councils, Inc., 1976 Google Scholar17. UTERMANNJAESCHKEMENZEL GMJ: Familial hyperlipoproteinemia type III: deficiency of a specific apolipoprotein (apo E-III) in the very low density lipoproteins. FEBS Lett 56:352-355, 1975 CrossrefMedlineGoogle Scholar18. FELDMANWANGADLERSBERG ECD: Effect of prolonged use of estrogens on circulating lipids in patients with idiopathic hyperlipemia or idiopathic hypercholesterolemia. Circulation 20:234-242, 1959 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited By9 Diabetes secondary to genetic disorders 1 November 1977Volume 87, Issue 5Page: 625-628KeywordsChemical analysisHyperlipidemiaLesionsLipidsLipoproteinsTendonsUltracentrifugation Issue Published: 1 November 1977 PDF DownloadLoading ...