tbuckley/cabot-search huggingface dataset:
Hyperplasia from GLP-1 drugs is "not a surprise," say researchers
Authors: D. Cohen
Journal: BMJ (2013)

A week after the US Food and Drug Administration announced that it was to review unpublished data from a group of unnamed researchers linking certain antidiabetes drugs with pancreatitis,1 the findings have been published in a specialty journal, Diabetes .2

The FDA’s statement said that glucagon-like peptide-1 (GLP-1) based drugs used to treat type 2 diabetes could raise the risk of pancreatitis and precancerous pancreatic lesions and induce pancreatic duct metaplasia.

However, the findings in the small study go further than the US agency suggested. 

Studies have previously shown that GLP-1 based drugs may cause pancreatic inflammation and focal proliferation in the exocrine pancreas in rodents. And a 2011 study published in Gastroenterology showed increased signals in the FDA’s adverse event reporting system of pancreatitis and pancreatic cancer in patients who used this class of drugs.3 

So researchers from the University of California at Los …
Pressure Wave Transmission in the Human Pulmonary Circulation
Authors: C. G. Caro, G. K. Harrison, P. Mognoni
Journal: Cardiovascular Research (1967)

Journal Article Pressure Wave Transmission in the Human Pulmonary Circulation Get access Colin G. Caro, Colin G. Caro † From the Department of Medicine, St. Thomas's Hospital, London † Now at Physiological Flow Studies Unit, Imperial College, London. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Kent Harrison, G. Kent Harrison From the Department of Medicine, St. Thomas's Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Piero Mognoni Piero Mognoni From the Department of Medicine, St. Thomas's Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 1, Issue 1, January 1967, Pages 91–100, https://doi.org/10.1093/cvr/1.1.91 Published: 01 January 1967 Article history Received: 27 June 1966 Published: 01 January 1967
Local and State Health Departments: Their Relation to Medical Practice — Present and Potential
Authors: Alfred L. Frechette
Journal: New England Journal of Medicine (1963)

AN attempt to describe the work of local and state health departments and to lay out a pattern for their future functioning in relation to medical practice is not unlike trying to describe the various shapes and colors that one sees on looking into a kaleidoscope. The task would be less difficult if the blend of patterns remained static, but they do not; the rotating mechanism is turned by the passage of time, and makes it necessary to report the viewer's visual experiences in an ever changing series of patterns within patterns. Communities and their health problems are constantly changing, . . .
The Nondiagnosis of Pernicious Anemia
Authors: CHARLES A. HALL
Journal: Annals of Internal Medicine (1965)

Article1 December 1965The Nondiagnosis of Pernicious AnemiaCHARLES A. HALL, M.D.CHARLES A. HALL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-951 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the 14-year lifetime of this hospital, 40 patients were admitted with untreated pernicious anemia. Only once did the referring or admitting physician send the patient to his ward with pernicious anemia listed as the most likely diagnosis. This less than enviable record suggested that either the physicians who saw these patients were not alert to the usual signs and symptoms of the disease, or that patients with pernicious anemia are not now presenting with the textbook picture. This study is a simple attempt to find out how these 40 cases presented and what diagnoses were made by the various...References1. WINTROBE MW: Clinical Hematology, 5th ed. Lea & Febiger, Philadelphia, 1961, p. 473. Google Scholar2. COX EV: The clinical manifestations of vitamin B12 deficiency in Addisonian pernicious anemia, in Vitamin B12 und Intrinsic Factor, edited by F. ENKE. Stuttgart, 1962, pp. 590-602. Google Scholar3. SEATONGOLDBERG DAA: Weight loss in pernicious anemia. Lancet 1: 1002, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES A. HALL, M.D.Affiliations: Albany, New YorkFrom the Medical Service, Veterans Administration Hospital, Albany, N. Y., and Albany Medical College, Albany, N. Y.Requests for reprints should be addressed to Charles A. Hall, M.D., Chief, Hematology Section, Veterans Administration Hospital, Albany, N. Y. 12208. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySelective oxidation of aromatic aldehydes to arenecarboxylic acids using ebselen-tert-butyl hydroperoxide catalytic systemBibliography Articles Cited in CommentariesA man with a prosthetic valve, anaemia, fever, and splenomegalyTriazoles XXXVI . The arylation of 5-amino-3-methylthio-1 H -1,2,4-triazole with activated aryl chloridesWhat are the Psychiatric Manifestations of Vitamin B 12 Deficiency?Relapses after interruption of cyanocobalamin therapy in patients with pernicious anemiaEvaluation of the Segal uropepsin test in screening for hypovitaminosis B12 1 December 1965Volume 63, Issue 6Page: 951-954KeywordsAnemiaColonMedical servicesPernicious anemiaSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 December 1965 PDF downloadLoading ...
Mortality Reporting and Pay-for-Performance Programs
Authors: Jamieson M. Bourque, Ashley R. Hurst, Mary Faith Marshall
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author's reply to Stainsby
Authors: B. Djavan
Journal: BMJ (2012)

Evaluation and analysis of complications of prostate needle biopsy are certainly crucial when discussing benefits and harms of biopsy in times of increasing numbers of biopsies and biopsy cores. Stainsby’s suggestions may seem attractive but do not reflect our current understanding and are not supported by the current literature.1

All studies quoted were performed before or in the early days …
Abstract 2025: Multicellular tumor spheroid 3D models to decipher cancer cell biology and to evaluate anticancer drugs
Authors: Bernard Ducommun, Valérie Lobjois
Journal: Cancer Research (2014)

Abstract MultiCellular Tumor Spheroid (MCTS) mimic the organization of a tumor and is considered as an invaluable model to study cancer cell biology and for the preclinical development of new antiproliferative drugs. We will report how engineering of MCTS in association with new technological developments can be used to explore the regionalization and the effects of novel drugs. We will demonstrate the potential of these 3D models to study the kinetics aspects of the response on live spheroids expressing fluorescent reporters and markers using light sheet microscopy (SPIM). We will also report the development of innovative microdevices dedicated to the study of the dynamics of MCTS formation and to the monitoring of mechanosensing and tumor growth-induced mechanical stress. We will present our latest advances on the characterization of these processes and on the use of these assays for the identification of new original targets and compounds. Citation Format: Bernard Ducommun, Valérie Lobjois. Multicellular tumor spheroid 3D models to decipher cancer cell biology and to evaluate anticancer drugs. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2025. doi:10.1158/1538-7445.AM2014-2025
Article removed after US complains it could help terrorists
Authors: Owen Dyer
Journal: BMJ (2005)

<h3>Objective</h3> Data errors are a well-documented part of clinical datasets as is their potential to confound downstream analysis. In this study, we explore the reliability of manually transcribed data across different pathology fields in a prostate cancer database and also measure error rates attributable to the source data. <h3>Design</h3> Descriptive study. <h3>Setting</h3> Specialist urology service at a single centre in metropolitan Victoria in Australia. <h3>Participants</h3> Between 2004 and 2011, 1471 patients underwent radical prostatectomy at our institution. In a large proportion of these cases, clinicopathological variables were recorded by manual data-entry. In 2011, we obtained electronic versions of the same printed pathology reports for our cohort. The data were electronically imported in parallel to any existing manual entry record enabling direct comparison between them. <h3>Outcome measures</h3> Error rates of manually entered data compared with electronically imported data across clinicopathological fields. <h3>Results</h3> 421 patients had at least 10 comparable pathology fields between the electronic import and manual records and were selected for study. 320 patients had concordant data between manually entered and electronically populated fields in a median of 12 pathology fields (range 10–13), indicating an outright accuracy in manually entered pathology data in 76% of patients. Across all fields, the error rate was 2.8%, while individual field error ranges from 0.5% to 6.4%. Fields in text formats were significantly more error-prone than those with direct measurements or involving numerical figures (p&lt;0.001). 971 cases were available for review of error within the source data, with figures of 0.1–0.9%. <h3>Conclusions</h3> While the overall rate of error was low in manually entered data, individual pathology fields were variably prone to error. High-quality pathology data can be obtained for both prospective and retrospective parts of our data repository and the electronic checking of source pathology data for error is feasible.
Vasopressin in the Evaluation of Pituitary-Adrenal Function
Authors: JOSEPH R. TUCCI
Journal: Annals of Internal Medicine (1968)

The plasma cortisol response to an intramuscular injection of 10 units of lysine vasopressin was evaluated in 19 normal subjects and in 35 patients with various disturbances of endocrine function and was compared with the response to standard adrenocorticotrophic hormone (ACTH) and metyrapone tests. A rise in plasma cortisol of 6 µg/100 ml or greater occurred in all 19 normal subjects and in 22 of the 35 patients studied. In general, the results of metyrapone and vasopressin testing were in agreement, but discordant results were obtained in 9 of the 35 patients. Two of these nine patients had a normal vasopressin but subnormal metyrapone response, and, conversely, seven patients had a subnormal vasopressin and normal metyrapone response. These data suggest that vasopressin may yield evidence of impaired ACTH release not otherwise shown by metyrapone. Furthermore, these data—particularly the diminished vasopressin responses in two patients with hypothalamic disease—raise serious doubt concerning the theory that hypothalamic and pituitary disease may be distinguished on the basis of vasopressin and metyrapone testing. Six of seven patients with Cushing's syndrome with adrenocortical hyperplasia, including one with a pituitary tumor, responded normally to vasopressin, whereas one patient with adrenocortical carcinoma failed to respond, thus supporting the contention that vasopressin may be useful in distinguishing Cushing's syndrome on a pituitary basis from that secondary to other causes. However, further studies are indicated in such patients, particularly in those with functioning adrenocortical adenoma and ectopic ACTH-producing tumor.
The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma
Authors: R Piva, S Deaglio, R Famà, R Buonincontri, I Scarfò, A Bruscaggin, E Mereu, S Serra, V Spina, D Brusa, G Garaffo, S Monti, M Dal Bo, R Marasca, L Arcaini, A Neri, V Gattei, M Paulli, E Tiacci, F Bertoni, S A Pileri, R Foà, G Inghirami, G Gaidano, D Rossi
Journal: Leukemia (2014)
Impairment of cerebral perfusion during obstructive sleep apneas.
Authors: E M Bålfors, K A Franklin
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Cerebral circulation was studied in six patients with obstructive sleep apnea (OSA) by transcranial Doppler. Cerebral blood flow velocity (CBFV), pulsatility index (Pi), intra-arterial radial blood pressure, transcutaneous blood gases, and respiration were recorded during sleep with or without apneas. There was a concomitant increase of mean arterial pressure (Pa) and CBFV by 11 +/- 6% (p < 0.001) and 15 +/- 6% (p < 0.001) compared with baseline at 5.1 +/- 2.4 and 5.3 +/- 2.6 s, respectively, after apnea termination. Pa and CBFV decreased to a minimum of -8 +/- 2% (p < 0.001) and -23 +/- 8% (p < 0.001), respectively, below baseline at 19.8 +/- 5.0 and 19.4 +/- 4.5 s after apnea. Values returned to baseline within 60 s, except during repetitive apneas, which were associated with prolonged periods of reduced Pa and CBFV. Pi changed inversely to CBFV and rose to 34 +/- 15% (p < 0.001) above baseline 19.5 +/- 5.5 s after the end of apnea because of a decrease in diastolic CBFV. There was a close correlation between Pa and CBFV (r = 0.67, p < 0.001), indicating that cerebral autoregulation is insufficient to protect the brain from rapid systemic pressure changes in OSA. The findings suggest that apneas during sleep are associated with profound changes in cerebral blood flow. Apnea-induced hypoxemia combined with reduced cerebral perfusion may predispose to nocturnal cerebral ischemia in patients with OSA.
Gastroenterology and Hepatology
Authors: Walter L. Peterson
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hodgkin's disease
Authors: E. L. Weinshel, B. A. Peterson
Journal: CA A Cancer Journal for Clinicians (1993)

The etiology of Hodgkin's disease is unknown, and the identity of the normal counterpart of the malignant cell involved in Hodgkin's disease remains controversial. Yet, three of every four patients diagnosed with Hodgkin's disease will be cured. This success in treatment is due in large part to the application of modern oncologic techniques, such as combination chemotherapy and the use of staging to guide therapy. This article reviews important advances in the understanding and treatment of Hodgkin's disease.
Theoretical considerations on a thermodynamic model of muscle action
Authors: H. C. Hemker, W. Th. Hermens
Journal: Cardiovascular Research (1971)

Journal Article Theoretical considerations on a thermodynamic model of muscle action Get access H. C. Hemker, H. C. Hemker From the Laboratory of Cardiobiochemistry, University Hospital, Leiden, Holland Search for other works by this author on: Oxford Academic PubMed Google Scholar W. Th. Hermens W. Th. Hermens From the Laboratory of Cardiobiochemistry, University Hospital, Leiden, Holland Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 5, Issue supp1, July 1971, Pages 84–86, https://doi.org/10.1093/cvr/5.supp1.84 Published: 01 July 1971
Deeper into Abortion
Authors: Bernard N. Nathanson
Journal: New England Journal of Medicine (1974)

In early 1969 I and a group of equally concerned and indignant citizens who had been outspoken on the subject of legalized abortion, organized a political action unit known as NARAL—then standing for National Association for Repeal of Abortion Laws, now known as the National Abortion Rights Action League. We were outspokenly militant on this matter and enlisted the women's movement and the Protestant clergy into our ranks. We used every device available to political-action groups such as pamphleteering, public demonstrations, exploitation of the media and lobbying in the appropriate legislative chambers. In late 1969 we mounted a demonstration outside . . .
LYSOSOMAL ENZYMES IN CELLS INFECTED WITH CYTOPATHIC AND NON-CYTOPATHIC VIRUSES
Authors: L. Mallucci, A. C. Allison
Journal: The Journal of Experimental Medicine (1965)

In chick embryo cells infected with fowl plague virus, an avian strain of influenza A which produces cytopathic effects, lysosomal enzymes were released from the particulate to the supernatant fraction of homogenates within 6 hours of infection. This change occurred in the presence of high concentrations of parafluorophenylalanine, suggesting that the changes were due to redistribution of preformed enzymes rather than to de novo protein synthesis. No such changes were observed when the Melbourne strain of influenza A virus multiplied in the same cell system without cytopathic effects. The possible role of lysosomal enzymes in virus uncoating and in the genesis of cytopathic effects is discussed.
Community-based asthma care: trial of a "credit card" asthma self-management plan
Authors: W D'Souza, J Crane, C Burgess, H Te Karu, C Fox, M Harper, B Robson, P Howden-Chapman, L Crossland, K Woodman, al. et
Journal: European Respiratory Journal (1994)

Although asthma self-management plans are widely recommended as essential in the long-term treatment of adult asthma, there have been few studies examining their use. Our objective was to assess the effect of a "credit card" adult asthma self-management plan in a community experiencing major health problems from asthma, by means of a before and after intervention trial of the efficacy of the "credit card" plan, when introduced through community-based asthma clinics. The participants were 69 Maori people with asthma. The "credit card" plan consisted of written guidelines for the self-management of asthma, based on self-assessment of asthma severity, printed on a plastic card. On one side, management guidelines were based on the interpretation of peak expiratory flow rate (PEFR) recordings, whilst the reverse side was based on symptoms. The outcome measures used were before and after comparison of markers of asthma morbidity and requirement for acute medical treatment; and a structured questionnaire assessing the acceptability and use of the credit card plan. Following the introduction of the plan, the mean PEFR increased from 347 to 389 l.min-1, the percentage of nights woken fell from 30.4 to 16.9%, and the number of days "out of action" fell from 3.8 to 1.7%. The requirements for acute medical treatment also fell during the intervention period. Most participants commented favourably on the content and usefulness of the plan. In the situation of worsening asthma, 28% of subjects found the peak flow side of the card most helpful, 7% the symptoms side, and 48% found both sides equally helpful.(ABSTRACT TRUNCATED AT 250 WORDS)
Audit of implantable cardioverter-defibrillators in a single UK centre
Authors: S. Gupta, H. Hasan, O. Valencia, S. Jones, E. Rowland, A J. Camm, C. W Pumphrey, D. E Ward
Journal: BMJ (1999)

EDITOR—We support Causer and Connolly's editorial emphasising the value of implantable cardioverter-defibrillators in patients with life threatening ventricular arrhythmias.1 A recent audit conducted in our cardiac unit highlights two additional issues: psychosocial concerns of patients and cost implications. We reviewed clinical records and psychosocial structured questionnaires of the 42 patients receiving their first implantable cardioverter-defibrillator (through pectoral routes) between January 1995 and February 1998 (table). To our knowledge, this is the first reported series of such patients in the …
Haemodynamic effects of beta-adrenergic blockade in hyperthyroid patients with and without heart failure.
Authors: H Ikram
Journal: BMJ (1977)

Haemodynamic studies were performed in 10 patients with uncomplicated thyrotoxicosis and seven with thyrotoxic cardiac failure. The cardiac output of those with uncomplicated hyperthyroidism was higher than normal at rest. After 2 mg of intravenous propranolol there was a 13% fall but the level was still higher than normal. In patients with thyrotoxic cardiac failure the resting cardiac output was normal, but it fell after propranolol by 30% to subnormal levels. In both groups there was an increase in right heart pressures and fall in the rate of increase in arterial pressure, which indicated a decrease in myocardial contractility. These results indicate that increased autonomic activity is a compensatory phenomenon in hyperthyroid heart failure and that its abolition by beta-blocking drugs has a deleterious effect on cardiac function. They are therefore contraindicated in patients with thyrotoxic heart failure.
Role of the atopy score and of single atopic features as risk factors for the development of hand eczema in trainee metal workers
Authors: U Berndt, U Hinnen, D Iliev, P Elsner
Journal: British Journal of Dermatology (1999)

This study was performed as part of PROMETES (Swiss Prospective Metal Worker Eczema Study) to examine the role of atopy as a possible risk factor for the development of hand eczema in trainee metal workers. In a cohort of 201 young men without any skin problems at the start of their apprenticeship, 9.5% developed signs of dermatitis on their hands within a period of 6 months. The 2. 5-year incidence was 23%. We did not find a significantly increased risk for hand eczema in those participants with an atopic skin diathesis according to the atopy score of Diepgen et al. (Dermatosen 1991; 39: 79-83) Analysis of individual atopic signs and symptoms showed reported metal reactivity to have a significant influence on the onset of early skin damage within 6 months, whereas a history of flexural eczema appeared to be significantly related to the overall incidence over 2.5 years.