tbuckley/cabot-search huggingface dataset:
ICON: Food allergy
Authors: A. Wesley Burks, Mimi Tang, Scott Sicherer, Antonella Muraro, Philippe A. Eigenmann, Motohiro Ebisawa, Alessandro Fiocchi, Wen Chiang, Kirsten Beyer, Robert Wood, Jonathan Hourihane, Stacie M. Jones, Gideon Lack, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2012)
Comparative Trial of Flunisolide and Beclomethasone Dipropionate Nasal Sprays in Patients with Seasonal Allergic Rhinitis
Authors: PEKKA SIPILÄ, MARTTI SORRI, KAUKO OJALA, ANTTI PALVA
Journal: Allergy (1983)

In order to evaluate the effects of flunisolide and beclomethasone dipropionate nasal sprays on seasonal allergic rhinitis, 45 patients were included in an open parallel comparative trial. The study design was open because of the different dosage schedules for the two preparations. Strict criteria were set up for patient selection, and all patients were carefully examined and assessed before and after the 4‐week trial period. Throughout the whole treatment each patient kept a detailed daily record. A substantial or complete control of symptoms was achieved in 18 of the 21 patients on flunisolide and in 20 of the 22 on beclomethasone dipropionate. No serious side effects were observed. Thus it can be concluded that both test drugs are effective and well tolerated in the treatment of seasonal allergic rhinitis.
Susan Fiona Haigh (Clarke)
Authors: E. H. K. J. S. K. S. Laurent
Journal: BMJ (2015)

Susan Fiona Haigh (“Fiona”) was born in South Africa. When she was a toddler the family moved to Yorkshire. Her father, Alan, a journalist, wrote against President Verwoerd’s government and was questioned by the secret police. Early in 1961 Margaret, her mother, therefore had to leave Johannesburg precipitously, with Fiona and her brother, on board a Comet freight airplane, landing at Addis, Cairo, and Rome, taking three days. They had to leave everything behind. …
Milton C. Paige, Jr. —<i>The Journal</i>'s Manager, Merchant and Mailman
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1977)

A visitor to the Journal office at 10 Shattuck Street finds two staffs identifiable as "editorial" and "business." Though their functions are to a large extent separate, their harmonious interaction is essential. The Journal these days could not do without either.At mid-century, conditions were quite different. Dr. Joseph Garland, who had become editor in 1947, was responsible for the totality of Journal activities, although he was aided by Robert O'Leary, literary editor, and Clara Davies, who acted as "office manager and general executive."1 The duties of the editor, responsible as he was then for both the quality of the . . .
Hematologic Effects of Intravesicular Thiotepa Therapy for Bladder Carcinoma
Authors: Dickerman Hollister
Journal: JAMA (1980)

Twenty-nine patients with bladder carcinoma treated with intravesical thiotepa administration were reviewed to assess hematologic toxicity. Ten of 25 consecutive patients had at least one episode of acute myelosuppression. Thrombocytopenia was the most common abnormality; anemia was uncommon. Acute suppression occurred most often within the first three months of therapy and was dose related. One of the 25 patients and four additional patients had chronic myelosuppression; all were male. They were older and had received more thiotepa over a longer period than those patients without chronic myelosuppression. Thrombocytopenia was again the most common abnormality. Anemia was nearly as frequent in this subpopulation and may herald chronic blood dyscrasia. One patient had refractory anemia with an excess of blast forms; another had smoldering leukemia. Acute and chronic forms of myelosuppression were not related. Thiotepa treatments should be limited to 90 mg/mo and protracted therapy avoided in elderly men. (<i>JAMA</i>244:2065-2067, 1980)
Ectopic Pregnancy in the United States
Authors: George L. Rubin
Journal: JAMA (1983)

Trends of the incidence and mortality associated with ectopic pregnancy (EP) in the United States were examined for 1970 through 1978. The estimated number of EPs rose from 17,800 in 1970 to 42,400 in 1978, and the EP incidence rate rose from 4.5 per 1,000 reported pregnancies to 9.4 during the same time period. The risk of EP was higher for older women and nonwhite women. Over 2.5% of all reported pregnancies among nonwhite women aged 35 to 44 years were ectopic. The death-to-case rate for EP declined almost 75% during the study period but remained consistently higher for nonwhite women as compared with white women. (<i>JAMA</i>1983;249:1725-1729)
Hypoxia-Reoxygenation
Authors: Tai-Ho Hung, Jeremy N. Skepper, D. Stephen Charnock-Jones, Graham J. Burton
Journal: Circulation Research (2002)

Preeclampsia is a severe disorder of human pregnancy characterized by generalized activation of maternal endothelial cells. Oxidative stress of the placenta is considered a key intermediary step, precipitating deportation of apoptotic fragments into the maternal circulation, but the cause remains unknown. We hypothesize that intermittent placental perfusion, secondary to deficient trophoblast invasion of the endometrial arteries, leads to an ischemia-reperfusion–type insult. We therefore tested whether hypoxia-reoxygenation (H/R) in vitro stimulates apoptosis in human placental tissues compared with controls kept hypoxic or normoxic throughout. After H/R, release of cytochrome c from mitochondria was significantly increased and was associated with intense immunolabeling for active caspase 3 in the syncytiotrophoblast and fetal endothelial cells. There was also increased labeling of syncytiotrophoblastic nuclei for cleaved poly (ADP-ribose) polymerase (PARP), and higher cytosolic concentrations of cleaved PARP fragment were detected by Western blot. Syncytiotrophoblastic nuclei displayed increased chromatin condensation, and a significantly greater percentage was TUNEL positive. These changes were accompanied by increased lactate dehydrogenase release into the medium. Preadministration of the free radical scavenger, desferrioxamine, reduced cytochrome c release and the TUNEL-positive index, suggesting generation of hydroxyl radicals mediates these processes. By contrast, hypoxia alone caused a smaller increase in the TUNEL-positive index, and the majority of syncytiotrophoblastic nuclei displayed karyolysis, whereas normoxic controls remained euchromatic. We conclude that H/R stimulates apoptotic changes within the syncytiotrophoblast, whereas hypoxia principally induces necrosis. The quality of placental perfusion may therefore be a more important factor in the pathophysiology of preeclampsia than the absolute quantity.
Importance of Endogenous Adenosine During Ischemia and Reperfusion in Neonatal Porcine Hearts
Authors: Hilchen T. Sommerschild, Frank Grund, Jon Offstad, Per Jynge, Arnfinn Ilebekk, Knut A. Kirkebøen
Journal: Circulation (1997)

Background Adenosine has several potentially cardioprotective effects. We hypothesized that the effects of endogenous adenosine vary with degree of ischemia and that elevating endogenous levels is protective. Methods and Results Isolated blood-perfused piglet hearts underwent 120 minutes of low-flow ischemia (10% flow) or 90 minutes of zero-flow ischemia, all with 60 minutes of reperfusion. Hearts were treated with either saline, the adenosine receptor blocker 8-sulfophenyltheophylline (8SPT, 300 μmol · L −1 ), or the nucleoside transport inhibitor draflazine (1 μmol · L −1 ). In separate groups, biopsies were obtained before and at the end of ischemia. Compared with saline, 8SPT did not significantly alter functional recovery in either protocol. Draflazine significantly improved percent recovery of left ventricular systolic pressure both in the low-flow protocol (92±3% versus 75±2% [saline] and 73±3% [8SPT], P &lt;.001 for both) and in the zero-flow protocol (76±3% versus 59±4% [saline] and 46±9% [8SPT], P &lt;.05 for both). In the zero-flow protocol, draflazine also significantly reduced ischemic contracture and release of creatine kinase. Tissue adenosine at the end of ischemia was elevated by draflazine compared with saline-treated hearts: after low-flow ischemia to 0.10±0.05 versus 0.00±0.00 μmol · g −1 dry wt ( P &lt;.05) and after zero-flow ischemia to 1.73±0.82 versus 0.15±0.03 μmol · g −1 dry wt ( P &lt;.05). Conclusions In neonatal porcine hearts, endogenous adenosine produced during ischemia does not influence ischemic injury or functional recovery. Elevating endogenous adenosine by draflazine elicits cardioprotection in both low-flow and zero-flow conditions.
TCT-127 Incidence, Predictors, and Prognostic Impact of Post-Discharge Bleeding After Percutaneous Coronary Intervention
Authors: Mayank Yadav, Philippe Genereux, Ajay J. Kirtane, Bernhard Witzenbichler, Ke Xu, Akiko Maehara, Roxana Mehran, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2014)
HYGIENE OF YOUNG GIRLS.
Authors: J. H. CARSTENS
Journal: JAMA (1903)

The hygiene of young girls has been discussed and written about so much that it is utterly impossible for me to say anything new or even to present the subject at a little different angle than you have looked at it before. When I speak of young girls I naturally mean during the age of puberty. We can divide the subject into mental and physical. The hygiene of the body is comparatively easy if the young girls are raised in a primitive state of civilization. Still, again, here there is a great difference. In some of the primitive races, as with certain tribes of Indians, girls have to do hard work, and do not grow up unrestrained as they do among some other primitive people. In the South Pacific islands, for instance, where they grow up without care and restraint, romping, playing, swimming, there they develop even muscular figures and
IL-15 constrains mast cell–dependent antibacterial defenses by suppressing chymase activities
Authors: Zane Orinska, Marcus Maurer, Farhad Mirghomizadeh, Elena Bulanova, Martin Metz, Natalia Nashkevich, Florian Schiemann, Jan Schulmistrat, Vadim Budagian, Julien Giron-Michel, Ernst Brandt, Ralf Paus, Silvia Bulfone-Paus
Journal: Nature Medicine (2007)
TCT-194 Clinical and Angiographic Outcomes of True versus False Lumen Stenting of Coronary Chronic Total Occlusions: Insights from Intravascular Ultrasound
Authors: Mahmoud M. Sabbah, Takeshi Tada, Kazushige Kadota, Seiji Habara, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2014)
A SEQUENCE OF BIOCHEMICAL EVENTS IN THE ANTIGEN-INDUCED RELEASE OF CHEMICAL MEDIATORS FROM SENSITIZED HUMAN LUNG TISSUE
Authors: Michael Kaliner, K. Frank Austen
Journal: The Journal of Experimental Medicine (1973)

Five sequential steps interspaced between the antigen activation of human lung fragments sensitized with IgE and the release of the chemical mediators, histamine and slow-reacting substance of anaphylaxis (SRS-A), have been delineated. The experimental design that permits this analysis is based upon the capacity to maintain the serine esterase essential to mediator release in its diisopropylphosphofluoridate (DFP)-resistant precursor state despite antigen challenge and upon the ability to arrest reversibly the reaction sequence by various manipulations. When sensitized lung fragments are challenged with antigen in the presence of DFP, a serine esterase is converted to its active DFP-inhibitable state; this conversion is prevented if antigen challenge in the presence of DFP occurs in calcium-free buffer indicating that immunologic activation of the esterase requires extracellular calcium. The fact that calcium depletion alone does not impair antigen-induced histamine release implies that prevention of esterase activation depends upon both the absence of extracellular calcium and the inactivation of any active esterase by DFP to prevent an autocatalytic feedback activation. Arresting the antigen-induced activation of the serine esterase by the combination of DFP in calcium-free buffer precludes the sequence from reaching the labile, 2-deoxyglucose (2-DG)-inhibitable, energy-requiring step, indicating that proesterase activation precedes this energy-requiring stage. The 2-DG-inhibitable step precedes a second calcium-requiring, EDTA-inhibitable stage, as EDTA prevents glucose reversal of 2-DG inhibition of antigen-challenged tissue, while the presence of 2-DG does not prevent calcium reversal of EDTA inhibition. The finding that isoproterenol prevents calcium reversal of EDTA inhibition of mediator release suggests that the inhibitory site of action of increased concentrations of cyclic AMP is coincident with or subsequent to the second calcium-requiring, EDTA-inhibitable step. Therefore, the sequence of biochemical events initiated by the interaction of antigen with tissue-fixed IgE antibodies appears to proceed from the calcium-requiring activation of a DFP-sensitive serine esterase; the further autocatalytic activation of the esterase; a 2-DG-inhibitable energy requirement; a second calcium-requiring, EDTA-inhibitable stage; and a cyclic AMP-inhibitable step to the release of histamine and SRS-A.
Screening for Intimate Partner Violence—Reply
Authors: Harriet L. MacMillan
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
I Am, as Usual, Fuming
Authors: Marshall Morgan
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I am, as usual, fuming after reading an installment of Health Care Policy: A Clinical Approach.<sup>1</sup>These articles insult one's intelligence. Drs Grumbach and Bodenheimer ask the reader to accept as typical this scenario: a cancer patient with persistent vomiting is serially mismanaged by her oncologist and her gastroenterologist. She then sees a nurse practitioner who quickly figures out what's going on and cures the problem, without spending a lot of money! Presumably, because of their training and clinical experience, nurse practitioners (clearly these are archetypes, not exceptional individuals) are better prepared to manage gastrointestinal complications of cancer chemotherapy than either oncologists or gastroenterologists. No evidence is offered to support this, and I can't buy it. Next comes the story about Dr Service's "bet" with Dr Caire. We are told that, by auditing medical charts, "a nurse specialized in quality improvement" was able to determine that
Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome
Authors: Catherine Dodé, Jacqueline Levilliers, Jean-Michel Dupont, Anne De Paepe, Nathalie Le Dû, Nadia Soussi-Yanicostas, Roney S. Coimbra, Sedigheh Delmaghani, Sylvie Compain-Nouaille, Françoise Baverel, Christophe Pêcheux, Dominique Le Tessier, Corinne Cruaud, Marc Delpech, Frank Speleman, Stefan Vermeulen, Andrea Amalfitano, Yvan Bachelot, Philippe Bouchard, Sylvie Cabrol, Jean-Claude Carel, Henriette Delemarre-van de Waal, Barbara Goulet-Salmon, Marie-Laure Kottler, Odile Richard, Franco Sanchez-Franco, Robert Saura, Jacques Young, Christine Petit, Jean-Pierre Hardelin
Journal: Nature Genetics (2003)
Immunochemical study of the malabsorption syndrome with cow's milk intolerance
Authors: E. Savilahti
Journal: Gut (1973)

The effect of cow's milk provocation on the immunoglobulins in the intestinal mucosa, intestinal juice, stool extracts, as well as on the levels of antibodies to cow's milk and beta-1C/A in serum, was studied in 18 infants with the malabsorption syndrome. The infants improved on breast milk and were therefore suspected to be intolerant to cow's milk and challenged with it. At the time of clinical relapse a marked and uniform increase in the numbers of IgA- and IgM-containing cells, 2.4 times as many on the average as before challenge, was observed in the jejunal mucosa of eight reacting patients at nine provocations with cow's milk. There was no abnormality in the immunoglobulin-containing cells before challenge or in biopsy specimens taken shortly after the resumption of the elimination diet (breast milk). The clinical reaction was preceded by a pronounced rise in the IgA and IgM contents of stool extracts, and a rise in the titre of haemagglutinating antibodies and serum IgA, changes which subsided rapidly after withdrawal of cow's milk. There was no evidence that the reaction was IgE-mediated or complement-consuming. In some of the 10 patients who tolerated cow's milk challenge clinically there was an increase in both IgA- and IgM-containing cells suggestive of a local immunological reaction although no clinical intolerance was provoked and other immunological signs were weak or absent. In other non-reacting patients no immunological reaction was noted. Therefore it is evident that cow's milk is the agent responsible for the strong local intestinal reaction coinciding with the clinical symptoms.
Diabetes and Risk of Non-Hodgkin's Lymphoma
Authors: Joanna Mitri, Jorge Castillo, Anastassios G. Pittas
Journal: Diabetes Care (2008)

To examine the epidemiologic association between diabetes and risk of non-Hodgkin's lymphoma (NHL).We searched MEDLINE for observational studies on the association between diabetes and NHL in adults using the keywords "diabetes" and "lymphoma." Prospective cohort studies that reported relative risks or standardized incidence ratios and case-control studies that reported odds ratios with 95% CIs were included. A random-effects model was used to combine results from the individual studies.A total of 15 manuscripts (reporting data from 5 prospective cohort and 11 case-control studies) met the inclusion criteria. Combining data from all studies, the risk ratio (RR) of developing NHL in patients with diabetes was 1.19 (95% CI 1.04-1.35). Based on prospective studies, patients with diabetes had an RR of developing NHL of 1.41 (1.07-1.88), without heterogeneity among studies (I(2) = 34.3%; P > 0.10). Based on case-control studies, patients with diabetes had an RR of 1.12 (95% CI 0.95-1.31) of developing NHL compared with people without diabetes, with some heterogeneity among studies (I(2) = 36.28%; P = 0.09).Diabetes is associated with a moderately increased risk of NHL, which is consistent with other reported associations between diabetes and malignancies. Future studies should focus on elucidating potential pathophysiologic links between diabetes and NHL.
Abstract 864: Benzyl isothiocyanate, a promising cancer chemopreventive constituent of cruciferous vegetables, inhibits epithelial to mesenchymal transition in human breast cancer cells <i>in vitro</i> and <i>in vivo</i>
Authors: Anuradha Sehrawat, Shivendra V. Singh
Journal: Cancer Research (2011)

Abstract Benzyl isothiocyanate (BITC), a constituent of cruciferous vegetables (e.g., garden cress), inhibits chemically-induced cancer in experimental rodents. We showed previously that BITC treatment inhibited growth of cultured (MDA-MB-231 and MCF-7) and xenografted (MDA-MB-231) human breast cancer cells by causing reactive oxygen species-dependent apoptosis, and suppressed mammary cancer development in a transgenic mouse model (MMTV-neu). We now demonstrate, for the first time, that BITC is a potent inhibitor of epithelial to mesenchymal transition (EMT) in cultured cells and tumor xenografts in vivo. Exposure of estrogen receptor negative (MDA-MB-231) and estrogen receptor positive human breast cancer cells (MCF-7) and a highly invasive pancreatic cancer cell line (PL-45) to pharmacologic concentrations of BITC (1 or 2.5 µmol/L) resulted in up-regulation of epithelial markers (e.g., E-cadherin and occludin) with a concomitant decline in protein levels of mesenchymal markers vimentin, fibronectin, snail, and/or c-Met. BITC-mediated induction of E-cadherin protein correlated with its transcriptional up-regulation. Experimental EMT induced by exposure to TGFβ and TNFα in a spontaneously immortalized and non-tumorigenic human mammary epithelial cell line (MCF-10A) was also largely reversible in the presence of BITC. Consistent with these results, the BITC treatment inhibited TGFβ/TNFα -induced migration by MCF-10A cells, which was partially but significantly attenuated by RNA interference of E-cadherin. Moreover, inhibition of MDA-MB-231 xenograft growth in vivo in female athymic mice by BITC administration correlated with a visible increase in protein level of E-cadherin and suppression of vimentin protein expression. In conclusion, the present study reports a novel anticancer effect of BITC involving inhibition of EMT, a process triggered during progression of carcinoma to invasive state. This investigation was supported by the USPHS grant RO1 CA129347-04, awarded by the National Cancer Institute. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 864. doi:10.1158/1538-7445.AM2011-864
Xeroderma pigmentosum and refractory anaemia in two first cousins
Authors: P. BERBIS, C. BEYLOT, C. NOE, M.S. DOUTRE, A. BROUSTET, Y. PRIVAT
Journal: British Journal of Dermatology (1989)

We report two first cousins with xeroderma pigmentosum who developed a refractory anaemia with excess of blasts which resulted in their deaths France.
Predicting Drug Response
Authors: Joan Stephenson
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal