tbuckley/cabot-search huggingface dataset:
PTU-044 Joint Endoscopic/Laparoscopic Procedures for Management of Complex Colonic Polyps
Authors: E Wesley, N L Bullen, N J Smart, S D Mansfield, T Shirazi
Journal: Gut (2013)

<h3>Introduction</h3> Polypectomy during colonoscopy can be challenging and is potentially dangerous. Patients with particularly challenging polyps have been traditionally referred for segmental colectomy. Laparo-endoscopic resection (LER) has been found to be safe and effective in other centres<sup>1,2</sup>. Laparascopic mobilisation of the colon for endoscopic sub-mucosal resection (EMR) has the potential to assist with the removal of complex polyps and can allow immediate management of complications. We implemented a pathway for patients who would previously have been offered segmental resection to undergo colonoscopy in theatre under general anaesthetic (GA) by an expert colonoscopist with a laparoscopic colorectal surgeon present to assist with laparoscopic mobilisation or proceed to segmental colectomy if required. Our aim was to assess the safety and feasibility of this new service and to compare our results to published data. <h3>Methods</h3> Cases were collected prospectively from February 2010 to September 2012. Data on patient demographics, indication, lesion site and size, index colonoscopist, LER surgeon and endoscopist, procedural details, length of hospital stay, completeness of endoscopic resection and complications were collected retrospectively by two independent investigators. <h3>Results</h3> 25 patients, (17 male) underwent GA colonoscopy in theatre for 26 polyps. Polyp size estimation at initial colonoscopy ranged from 10–50mm, median 25mm. 15 polyps were in the right colon. 8 (32%) required segmental colectomy: 5 lesions appeared malignant, 1 was too large, 1 and 2 technically impossible to resect. 2 cases required laparoscopic mobilisation of the colon to aid EMR. 15 patients (60%) avoided any abdominal surgical intervention. Median length of hospital stay was 1 day. 2 patients had significant post-operative bleeding (1 EMR, 1 port-site). 1 patient developed a collection after laparoscopic resection which required radiological drainage. 1 EMR patient had polyp cancer with inadequate resection margins and required subsequent laparoscopic resection. <h3>Conclusion</h3> Although the number of patients is relatively small, the pathway is a safe and feasible way to reduce the need for colonic resection for complex polyps. A significant number of patients avoided the need for segmental resection, and most did not require any laparoscopic assistance. <h3>Disclosure of Interest</h3> None Declared <h3>References</h3> Franklin, M.E., Jr.,<i></i><i>et al.</i> Laparoscopically monitored colonoscopic polypectomy: an established form of endoluminal therapy for colorectal polyps. <i>Surgical endoscopy</i><b>21</b>, 1650–1653 (2007). Wood, J.J., Lord, A.C., Wheeler, J.M. &amp; Borley, N.R. Laparo-endoscopic resection for extensive and inaccessible colorectal polyps: a feasible and safe procedure. <i>Annals of the Royal College of Surgeons of England</i><b>93</b>, 241–245 (2011).
Social consequences. The 'pill scare': the responses of authorities, doctors and patients using oral contraception
Authors: A Szarewski
Journal: Human Reproduction Update (1999)

In October 1995, the regulatory authority in the UK issued a warning about an increased risk of venous thromboembolism in women taking third-generation combined oral contraceptives. This was done before publication of the scientific papers involved, and resulted in a huge media 'pill scare'. the manner in which the information was released has been criticised, as many doctors did not receive their 'Dear Doctor' letter from the regulatory authority until after media reporting. The result of the scare has been a loss of confidence in the oral contraceptive pill in general, and a rise in abortion rates. Key words: oral contraception/patient confidence/'pill scare'/regulatory authority/third-generation COC
Scientists accuse animal rights activists of stifling research
Authors: S. Kumar
Journal: BMJ (2002)

Scientists in India are up in arms against the animal rights watchdog committee headed by Maneka Gandhi, the former minister for animal rights.

The tussle between the National Institute of Immunology, Delhi, and Ms Gandhi's Committee for Prevention of Cruelty in Scientific Experiments on Animals (CPCSEA) has led to a police complaint and a court case.

After a sudden inspection visit by three committee members in September 2002, reports appeared in some national dailies at the end of October referring to “barbaric and brutal experimentation” on animals and quoted Ms Gandhi as saying, …
Interferon: cloudy but intriguing future
Authors: Roger S. Johnson
Journal: JAMA (1981)

Interferon was celebrated at the first annual International Congress for Interferon Research in Washington, DC. The conference, organized by the<i>Journal of Interferon Research</i>and Scherago Associates, Inc, an advertising and marketing company in New York City, had an air of upstage scientific excitement and backstage financial intrigue. With some of the biggest stars of the interferon research and business worlds crowded together in one hotel, it was difficult to mask the conflict with smiles and diplomacy. Real and potential interferon producers and brokerage companies were gleaning information instead of selling or exhibiting products. There were even stories of black market interferon and of a wealthy cancer patient offering half a million dollars to researchers for interferon therapy. On the second day of the conference, clinicians from Europe and the United States reported on the results of several clinical trials of interferon in cancer and antiviral therapy. The results were
Injuries From Fireworks
Authors: Jeffrey R. Harris
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Effective in 1982, Washington state changed its law governing the sale of fireworks during the July 4 holiday period. Previously, only nonexplosive ground-display devices known as "Safe and Sane Fireworks" were legally available in the state, elsewhere than on Indian reservations, where aerial devices and exploding firecrackers containing less than 50 mg of gunpowder were legally available. This year, all three types, except skyrockets and missile rockets, were sold throughout the state. To determine if this change in the law affected the number of fireworks-related injuries, we contacted 15 hospitals in nine counties and asked them to report the number of fireworks-related emergency room visits for June 28 to July 6, the period of legal fireworks sale, for 1981 and 1982. The hospitals surveyed are distributed throughout Washington state, and we assume that neither the population served nor the number of emergency room visits for other causes
A Case of Myx dema with Insanity Treated by Injection with Extract of Thyroid Gland
Authors: E. C. Carter
Journal: BMJ (1892)

EXTRACT IN MYXCEDEMA. [MTHE JouT 805 the transplanted flap there are three lines a little redder and smoother than the neighbouring skin; these lines are cicatri- tial tissue and correspond to the spots of partial sloughing L
IT gurus attempt to win doctors' hearts and minds
Authors: Michael Cross
Journal: BMJ (2005)

Technical difficulties have contributed to delays in the NHS electronic booking project in England. But lack of support from GPs is also an issue. What is happening with the entire national information technology programme, which is essential for the new look NHS?

It has been a difficult month for the national IT programme for the NHS, launched in 2002. The National Audit Office, in its first investigation into the ongoing programme, found that technical difficulties had contributed to delays in one key element, the electronic booking project, an essential part of the government's ambitions to extend patients' choice in the NHS ( BMJ 2005;330: 166, 22 Jan). Mean-while, a long running dispute with the largest supplier of GPs' computers continued to escalate.

Against that background, the IT programme is preparing a publicity campaign to win hearts and minds as the process begins of installing a new system for electronic care records, underpinning the electronic booking system, across England.

The NHS care records service will change current record systems by putting more than 50 million records on a digital database, allowing information to be shared safely across the NHS. For the first time there will be a central record of a patient's care, which will include information such as whether a …
Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer
Authors: Yi-Hsin Hsu, Jun Yao, Li-Chuan Chan, Ting-Jung Wu, Jennifer L. Hsu, Yueh-Fu Fang, Yongkun Wei, Yun Wu, Wen-Chien Huang, Chien-Liang Liu, Yuan-Ching Chang, Ming-Yang Wang, Chia-Wei Li, Jia Shen, Mei-Kuang Chen, Aysegul A. Sahin, Anil Sood, Gordon B. Mills, Dihua Yu, Gabriel N. Hortobagyi, Mien-Chie Hung
Journal: Cancer Research (2014)

Abstract Triple-negative breast cancer (TNBC) is a highly heterogeneous and recurrent subtype of breast cancer that lacks an effective targeted therapy. To identify candidate therapeutic targets, we profiled global gene expression in TNBC and breast tumor-initiating cells with a patient survival dataset. Eight TNBC-related kinases were found to be overexpressed in TNBC cells with stem-like properties. Among them, expression of PKC-α, MET, and CDK6 correlated with poorer survival outcomes. In cases coexpressing two of these three kinases, survival rates were lower than in cases where only one of these kinases was expressed. In functional tests, two-drug combinations targeting these three kinases inhibited TNBC cell proliferation and tumorigenic potential in a cooperative manner. A combination of PKC-α-MET inhibitors also attenuated tumor growth in a cooperative manner in vivo. Our findings define three kinases critical for TNBC growth and offer a preclinical rationale for their candidacy as effective therapeutic targets in treating TNBC. Cancer Res; 74(17); 4822–35. ©2014 AACR.
Payment to egg donors is to be tripled to remedy shortage
Authors: C. Dyer
Journal: BMJ (2011)

<h3>Aims</h3> To evaluate how often paediatricians recognise and manage obesity in children they see in outpatient clinics. <h3>Methods</h3> An audit of outpatient clinic consultations during a calendar month in both general paediatrics and paediatric endocrinology. All children with a body mass index (BMI) ≤ 98th percentile had their notes reviewed for evidence that the clinician had recognised their obesity, arranged appropriate investigations for hormonal causes and co morbidities and given lifestyle advice or referral to a community obesity programme. The results were fed back during a post clinic meeting. Clinicians were given written material on the National Institute for Health and Clinical Excellence (NICE) obesity guidelines and the local community obesity programme. UK BMI management charts were displayed in all clinic rooms. A repeat audit evaluated any change in obesity recognition and management. <h3>Results</h3> A total of 157 patient visits occurred during the audit period, including 21 obese children. 6/10 and 5/11 of the obese children attending the paediatric endocrinology and general clinics, respectively, were recognised as having a weight problem. Fewer than half the children were asked for appropriate family history, had a body mass index (BMI) measurement, or investigations for hormonal causes or co morbidities; apart from in the endocrinology clinic where 8/10 obese children had thyroid function tested. 3/10 in the endocrinology clinic and 3/11 in the general clinic had lifestyle advice or referrals to the obesity service. In the repeat audit 15/147 patients attending either the endocrinology or general clinics were obese. 5/9 and 2/6 in the endocrine and general clinics, respectively, were recognised as obese; no statistical change from the initial audit. There was no increase in the numbers of diagnosed obese children being investigated or offered help with weight loss. <h3>Conclusion</h3> A large proportion of the obese children attending endocrinology and general clinics in a teaching hospital are not recognised as having a weight problem and less than half are investigated or managed in accordance with NICE guidance. Feedback of the audit results, displaying BMI charts in clinic rooms, and providing written information on the NICE guidelines and referral options, did not improve the results.
Assessment of the action of mixed irradiation.
Authors: S Suzuki
Journal: Environmental Health Perspectives (1997)

Problems associated with the environmental and health perspectives of mixed irradiation are identified and the application of theoretical models is discussed. Four definitions of synergism were examined with regard to the action of mixed irradiation, and it was determined that all these definitions are inappropriate. Thus, I concluded that the term synergism or its synonym should not be used for the action of mixed irradiation unless a reasonable definition and evidence of the mechanism are provided. The Zaider-Rossi model and the extended Zaider-Rossi model, which can be applied to any type of mixed irradiation with two types of radiation, are useful for assessing the effects of mixed irradiation using the parameters for two types of single irradiation. Furthermore, models were proposed for very short and very long simultaneous mixed irradiation with multiple types of radiation. These models also would be helpful to assess the environmental and health perspectives of mixed irradiation.
CARBON TETRACHLORIDE AND OIL OF CHENOPODIUM IN HELMINTHIASIS
Authors: J. G. Reed
Journal: BMJ (1923)

TREATMENT OF HELMINTHIASIS.rM MDrcALJOm"XA that the immunity mechanism was in a state of continuous irritability.Perhaps this may be the condition quite frequently when patients do not improve under vaccine treatment, and vet suffer no obvious reaction.So groatly was I impressed-with the value of peptonie injections, that it seemed possible that here might be a solution of the problem one often has to deal with-namely, that of the patient who can only come for three weeks' or a month's treatment, and then has to return to her own d6ctor to have her vaccines, and who for financial reasons will certainly not be able to return if the treatment does not succeed.The following case illustrates this.I started straight away with peptone injections, so as to prevent the development of sensitiveness.After returning home the patient's own doctor was able to carry on the treatment without difficulty. CASE IV.On June 28th, 1922, I saw in consultation a case of general and severe arthritis, chiefly affecting the knee-joint, in a woman aged 48.She had not been out of bed for four months and was quite unable to walk, but happily there were no contractures.The knee-joints were at the time the worst parts, but practically every joint with the exception of the spine was affected.Owing to financial and other reasons, it was impossible for tlhe patient to come under my care except for a very short time.How- ever, with only eight days to work upon, I started at once, on July 1st, with 0.1 c.cm. of a 2 per cent.solution of peptone.On July 3rd 0.2 c.cm. was given, on July 4th 0.4 c.cm., on July 5th 0.8 c.cm., on July 6th 1 c.cm., and on July 7th 1.4 c.cm., which I combined with half a million M. deformwans.At the same time
A Clinical Manual of Diseases of the Eye, Including a Sketch of Its Anatomy.
Authors: D. B. St. John Roosa
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Branched-Chain Amino Acid-Free Parenteral Nutrition in the Treatment of Acute Metabolic Decompensation in Patients with Maple Syrup Urine Disease
Authors: G T Berry, R Heidenreich, P Kaplan, F Levine, A Mazur, M J Palmieri, M Yudkoff, S Segal
Journal: New England Journal of Medicine (1991)

MAPLE syrup urine disease is a rare inborn error of branched-chain amino acid and branched-chain keto acid metabolism due to decreased branched-chain α-keto acid dehydrogenase-complex activity.1 The branched-chain keto acids, which are the substrates in this irreversible enzyme reaction, are derived from transamination of the branched-chain amino acids leucine, isoleucine, and valine. Consumption of branched-chain amino acids in the form of dietary protein in excess of an age-dependent daily requirement for protein synthesis results in the accumulation of branched-chain amino acids and branched-chain keto acids in the tissues and body fluids of patients in whom there is little or no . . .
Paediatricians did not have duty of care to patient's mother
Authors: C. Dyer
Journal: BMJ (2002)

A mother who alleged that Professor David Southall and another paediatrician caused her to develop a psychiatric illness by wrongly diagnosing her child as a possible victim of Munchausen syndrome by proxy is taking her case to the Court of Appeal after it was thrown out by a judge at Chester county court.

Judge Hale ruled that Professor Southall and Dr Karen Whiting, a community paediatrician, owed no duty of care to Janet Davies, mother of Michael, and therefore no claim for negligence could proceed against the former East Berkshire Health Authority, Dr Whiting's employer.

Michael, then aged nearly 6 years, …
Does benzene cause multiple myeloma? An analysis of the published case-control literature.
Authors: S Bezabeh, A Engel, C B Morris, S H Lamm
Journal: Environmental Health Perspectives (1996)

Two case series and two epidemiological studies in the 1970s and 1980s suggested that benzene exposure might be a risk factor for multiple myeloma. An analysis has now been conducted of the published population-based and hospital-based case-control studies published through mid-1995 that permit examination of the relationship between multiple myeloma and benzene exposure or surrogates for benzene exposure. No increased association was found between multiple myeloma and benzene exposure or exposure to chemical groups that included benzene. The odds ratios from these analyses approximated 1.0. Exposures to petroleum products and employment in petroleum-related occupations did not appear to be risk factors for multiple myeloma. Cigarette smoking, as a surrogate of benzene exposure, was not found to be associated with myeloma, while some studies of products of combustion described as "engine exhaust" did show a significant association with multiple myeloma. In toto, the population-based and hospital-based case-control literature indicated that benzene exposure was not a likely causal factor for multiple myeloma.
Letter by Thalhammer et al Regarding Article, “External Carotid Artery–Internal Jugular Vein Fistula: A Complication of Internal Jugular Cannulation”
Authors: Christoph Thalhammer, Markus Aschwanden, Kurt A. Jaeger
Journal: Circulation (2006)

We read with interest the report by Sharma et al 1 describing a case of an arteriovenous fistula between the external carotid artery and the internal jugular vein.We would like to comment on the presentation, which, in our opinion, raises some important questions.Physical examination was remarkably atypical for an arteriovenous fistula of a large artery; we would expect a systolic and diastolic bruit and a palpable thrill in the area of a relevant arteriovenous fistula. 2 Worsening heart failure, as in the presented patient, can only be caused by large fistulas with high-volume flow. 2 An arteriovenous fistula results in a channel, which allows the high-pressure arterial blood to flow into the low-pressure venous system. 3This must result in a low-resistance flow pattern in the feeding artery, namely, the common and proximal external carotid artery and a continuous high-velocity waveform with arterialized peaks in the efferent vein. 3The presented color Doppler investigation with a low pulse-repetition frequency (15 cm/s) demonstrates aliasing in neither the systolic nor the diastolic phase, suggesting that the assumed fistula represents the first side branch of the external artery (ie, the superior thyroid artery).Venous Doppler flow pattern in the internal jugular vein shows an accentuated cardiac modulation that is consistent with congestive heart failure.Thus, in our opinion, the presented clinical and duplex sonographic findings do not document a relevant arteriovenous fistula, and the reported diagnosis seems unlikely.
315 I148M PNPLA3 POLYMORPHISM IS ASSOCIATED WITH CLINICAL FEATURES IN PATIENTS WITH HEPATOCELLULAR CARCINOMA
Authors: L. Valenti, B. Motta, G. Soardo, C. Bertelli, A. Sangiovanni, R. Rametta, P. Dongiovanni, M. Colombo, S. Fargion, A.L. Fracanzani
Journal: Journal of Hepatology (2012)
Water immersion attenuates short-latency somatosensory evoked potentials in a human EEG study
Authors: D Sato, K Yamashiro, H Onishi, Y Shimoyama, T Yoshida, A Maruyama
Journal: British Journal of Sports Medicine (2011)

During water immersion, we receive several somatosensory input from water, including tactile, pressure and thermal stimuli. In a clinical study involving water immersion, balance ability improved in subjects who rested in a sitting position in water twice a week for five successive weeks. This result suggests that somatosensory input from water may affect the central nervous system, specifically the cerebral cortex. In the present study, we examined the effect of water immersion on short-latency somatosensory evoked potentials (SSEPs) to median nerve stimuli. SSEP recordings were obtained for eight healthy male volunteers. SSEPs were measured at rest under the two environmental conditions: on land and in water. Ambient and water temperatures were set at 30°C under both the conditions. Water was poured up to the axilla level of each subject. A SynAmp amplifier system and the Scan 4.3 software (Neuroscan, El Paso, Texas, USA) were used to record electroencephalographic data. Recordings were obtained from nine scalp electrodes placed at F3/F4, C3/C4, P3/P4, Fz, Cz and Pz according to the 10–20 system. The right median nerve at the wrist was electrically stimulated with the stimulus duration of 0.2 ms at a frequency of 3 Hz. The intensity of the stimulus was fixed at approximately three times the sensory threshold. The following components were consistently recorded in all subjects: P20, N30 and P45 at F3 and Fz, N18, P22, N30 and P45 at C3 and Cz, and N20, P27, N33 and P45 at P3 and Pz. Significant difference between the conditions were found for P45 at C3 and Cz as well as for P27 and P45 at P3 and Pz. We confirmed that water immersion induces significant attenuation (gating) of SSEPs to the median nerve and that it modulates SSEPs known to originate in areas 3b and 1 of SI. We considered SSEP attenuation to be caused by centripetal gating, which suggested that water immersion influences the cortical processing of the somatosensory input.