THE EFFECT OF CORTISONE AND RELATED STEROIDS ON THE CARDITIS OF RHEUMATIC FEVER
Authors: PAUL W. CLOUGH
Journal: Annals of Internal Medicine (1956)

Editorial1 February 1956THE EFFECT OF CORTISONE AND RELATED STEROIDS ON THE CARDITIS OF RHEUMATIC FEVERPAUL W. CLOUGHPAUL W. CLOUGHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-2-426 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe highly favorable immediate effects of ACTH and cortisone in rheumatic fever were described by Hench et al.1soon after their first report of their effectiveness in rheumatoid arthritis. The fever, malaise, tachycardia and other systemic symptoms of the acute illness as well as the pain and local inflammation of the arthritis subside with remarkable rapidity and great regularity, although all too prone to recur promptly if treatment is stopped prematurely. These effects, however, are not radically different from those which may usually be obtained from salicylates in adequate quantities. Although the relief from cortisone in full doses is perhaps...1 Hench PS: Effects of adrenal cortical hormone 17-hydroxy-11-dehydrocorticosterone (compound E) on acute phase of rheumatic fever: preliminary report, Proc. Staff Meet., Mayo Clin. 24: 277-297, 1949. MedlineGoogle Scholar2 Graef I: Studies in rheumatic fever. I. The natural course of acute manifestations of rheumatic fever uninfluenced by "specific" therapy, Am. J. M. Sc. 185: 197-210, 1933. CrossrefGoogle Scholar3 Kelley VC: Corticotropin (ACTH) therapy of initial attacks of acute rheumatic fever in children, Am. J. Dis. Child. 84: 151-164, 1952. Google Scholar4 Greenman L: Cortisone therapy of initial attacks of rheumatic carditis, Am. J. Dis. Child. 89: 442-450, 1955. Google Scholar5 JohnsonFerencz ALC: Effect of cortisone therapy on incidence of rheumatic heart disease, New England J. Med. 248: 845-847, 1953. CrossrefMedlineGoogle Scholar6 Rowe RD: Use of ACTH, cortisone and salicylate in treatment of acute rheumatic fever, Canad. M. A. J. 68: 15-20, 1953. MedlineGoogle Scholar7 Massell BF: ACTH and cortisone therapy of rheumatic fever and rheumatic carditis, New England J. Med. 251: 183-190, 221-227, and 263-270, 1954. CrossrefMedlineGoogle Scholar8 The treatment of acute rheumatic fever in children. A coöperative clinical trial of ACTH, cortisone and aspirin, Circulation 11: 343-377, 1955. CrossrefGoogle Scholar9 Fischel EE: Observations on treatment of rheumatic fever with salicylate, ACTH and cortisone, Medicine 31: 331-355, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL W. CLOUGH PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (THIRTEENTH RHEUMATISM REVIEW)*CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P.(C), MAX M. MONTGOMERY, M.D., F.A.C.P., HOWARD F. POLLEY, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CARLOS F. SACASA, M.D., F.A.C.P., OTTO STEINBROCKER, M.D., HANS WAINE, M.D., GEORGE M. WILSON JR., M.D.Observations on the treatment of rheumatic fever with salicylate, ACTH and cortisone. II. Combined salicylate and corticoid therapy and attempts at rebound suppression 1 February 1956Volume 44, Issue 2Page: 426-431KeywordsAdrenocorticotropic hormoneArthritisFeversInflammationMyocarditisRheumatic feverRheumatoid arthritisSalicylatesSteroidsTachycardia ePublished: 1 December 2008 Issue Published: 1 February 1956 PDF downloadLoading ...