Evaluation of the Relative Value of Diagnostic Tests in Hyperparathyroidism
Authors: Laurence H. Kyle, William R. Beisel, John J. Canary
Journal: Annals of Internal Medicine (1962)

Article1 December 1962Evaluation of the Relative Value of Diagnostic Tests in HyperparathyroidismLAURENCE H. KYLE, M.D., F.A.C.P., WILLIAM R. BEISEL, JOHN J. CANARY, M.D.LAURENCE H. KYLE, M.D., F.A.C.P.Search for more papers by this author, WILLIAM R. BEISELSearch for more papers by this author, JOHN J. CANARY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-6-957 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of the measurement of phosphate excretion as a diagnostic test in parathyroid dysfunction, data supplied from a number of laboratories have stimulated discussion along 2 major lines: [1] the best method of measuring phosphate excretion, and [2] evaluation of the value of hyperphosphaturia in the diagnosis of hyperparathyroidism. Recommended methods of measuring phosphate excretion include percentage of tubular reabsorption of phosphate, the "phosphate excretion index," measurement of the tubular maximum for phosphate [TmP], and phosphate clearance [Cp] (1-5). Our laboratories have presented data attesting to the superiority of phosphate clearance (4,6). There has been a wide range...References1. SCHAAFKYLE MLH: Measurement of the per cent renal phosphorus reabsorption in the diagnosis of hyperparathyroidism. Amer. J. Med. Sci. 228: 262, 1954. CrossrefMedlineGoogle Scholar2. NORDIN BE: Primary and secondary hyperparathyroidism. Advance. Intern. Med. 9: 81, 1958. MedlineGoogle Scholar3. SIROTA JH: Renal tubule reabsorption of phosphate in hyperparathyroidism before and after removal of parathyroid adenoma. (Abstract) Fed. Proc. 12: 133, 1953. Google Scholar4. KYLESCHAAFCANARY LHMJJ: Phosphate clearance in the diagnosis of parathyroid dysfunction. Amer. J. Med. 24: 240, 1958. CrossrefMedlineGoogle Scholar5. WILLIAMSDEWALTWINTERSHOLLANDERWELTBURNETT TFJLRVWLGCH: Comparison of methods for evaluating renal excretion of phosphate in hyperparathyroidism. (Abstract) Clin. Res. 6: 248, 1958. Google Scholar6. BEISELGERARDBARRYHERNDONMERONEYKYLE WRESKGEGWHLH: Phosphate abnormalities in hyperparathyroidism. Metabolism 10: 10, 1961. Google Scholar7. REYNOLDSLANMANTUPIKOVA TBHN: Maximum tubular reabsorption of phosphate (TmP) in hyperparathyroidism. J. Clin. Endocr. 20: 1136, 1960. CrossrefGoogle Scholar8. CHAMBERSGORDONGOLDMANREIFENSTEIN ELGSLEC: Tests for hyperparathyroidism: TRP, PO4 deprivation, and calcium infusion. J. Clin. Endocr. 16: 1507, 1956. CrossrefMedlineGoogle Scholar9. GOLDMANGORDONCHAMBERS LGSEL: Changing diagnostic criteria for hyperparathyroidism. Ann. Surg. 146: 407, 1957. CrossrefMedlineGoogle Scholar10. BRUSHBLOCK BEMA: Newer methods in the diagnosis of hyperparathyroidism. Arch. Surg. 75: 953, 1957. CrossrefGoogle Scholar11. THOMASCONNORMORGAN WCTBHG: Some observations on patients with hypercalcemia, exemplifying problems in differential diagnosis, especially in hyperparathyroidism. J. Lab. Clin. Med. 52: 11, 1958. MedlineGoogle Scholar12. THOMASCONNORMORGAN WCTBHG: Diagnostic considerations in hypercalcemia; with a discussion of the various means by which such a state may develop. New Engl. J. Med. 260: 591, 1959. CrossrefMedlineGoogle Scholar13. FRAMEHAUBRICH BWS: Peptic ulcer and hyperparathyroidism (a survey of 300 ulcer patients). Arch. Intern. Med. 105: 536, 1960. CrossrefMedlineGoogle Scholar14. GORDON GS: Editorial comments in Year Book of Endocrinology (1959-1960, Year Book Series), Year Book Publishers, Inc., Chicago, 1960, pp. 140 and 147. Google Scholar15. REYNOLDSLANMANTUPIKOVA TBHN: Reevaluation of phosphate excretion tests in the diagnosis of hyperparathyroidism. Arch. Intern. Med. 106: 48, 1960. CrossrefGoogle Scholar16. KYLECANARYMINTZDE LEON LHJJDHA: Inhibitory effects of hypercalcemia on secretion of parathyroid hormone. J. Clin. Endocr. 22: 52, 1962. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.From the Department of Medicine, Georgetown University School of Medicine, the Department of Metabolism, Division of Medicine, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, and the Georgetown University Hospital, Washington, D. C.Presented at the Forty-third Annual Session of The American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.This material has been reviewed by the Office of The Surgeon General, Department of the Army, and there is no objection to its presentation and/or publication. This review does not imply any indorsement of the opinions advanced or any recommendation of such products as may be named.Requests for reprints should be addressed to Laurence H. Kyle, M.D., Department of Medicine, Georgetown University Hospital, 3800 Reservoir Road, N.W., Washington 7, D. C. 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