Hyperlactatemia due to Nevirapine
Authors: George Panos, Petros Kopterides, Matthew E. Falagas
Journal: Annals of Internal Medicine (2006)

Letters5 December 2006Hyperlactatemia due to NevirapineGeorge Panos, MD, PhD, Petros Kopterides, MD, and Matthew E. Falagas, MD, MSc, DScGeorge Panos, MD, PhDFrom 1st IKA Hospital and “Attikon” University Hospital and Alfa Institute of Biomedical Sciences, Athens, Greece, and Tufts University School of Medicine, Boston, Massachusetts.Search for more papers by this author, Petros Kopterides, MDFrom 1st IKA Hospital and “Attikon” University Hospital and Alfa Institute of Biomedical Sciences, Athens, Greece, and Tufts University School of Medicine, Boston, Massachusetts.Search for more papers by this author, and Matthew E. Falagas, MD, MSc, DScFrom 1st IKA Hospital and “Attikon” University Hospital and Alfa Institute of Biomedical Sciences, Athens, Greece, and Tufts University School of Medicine, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-11-200612050-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Hyperlactatemia is a well-known adverse reaction in HIV-infected patients who are treated with nucleoside analogue reverse transcriptase inhibitors (NRTIs) (1). However, data on its association with the other 2 widely used classes of antiretroviral agents, nonnucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors, are inconclusive. To our knowledge, no cases of hyperlactatemia secondary to nevirapine use have been reported to date.Objective: To describe a patient with nevirapine-induced hyperlactatemia who gradually recovered after cessation of treatment.Methods and Findings: A 36-year-old man received a diagnosis of HIV infection in November 2000 and began receiving azidothymidine–lamivudine–nevirapine in January 2001. He ...References1. Claessens YE, Chiche JD, Mira JP, Cariou A. Bench-to-bedside review: severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors. Crit Care. 2003;7:226-32. [PMID: 12793872] CrossrefMedlineGoogle Scholar2. Claessens YE, Cariou A, Monchi M, Soufir L, Azoulay E, Rouges P, et al. Detecting life-threatening lactic acidosis related to nucleoside-analog treatment of human immunodeficiency virus-infected patients, and treatment with L-carnitine. Crit Care Med. 2003;31:1042-7. [PMID: 12682470] CrossrefMedlineGoogle Scholar3. Bowers JM, Bert-Moreno A. Treatment of HAART-induced lactic acidosis with B vitamin supplements. Nutr Clin Pract. 2004;19:375-8. [PMID: 16215128] CrossrefMedlineGoogle Scholar4. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239-45. [PMID: 7249508] CrossrefMedlineGoogle Scholar5. Imhof A, Ledergerber B, Günthard HF, Haupts S, Weber R. Risk factors for and outcome of hyperlactatemia in HIV-infected persons: is there a need for routine lactate monitoring? Clin Infect Dis. 2005;41:721-8. [PMID: 16080096] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: George Panos, MD, PhD; Petros Kopterides, MD; Matthew E. Falagas, MD, MSc, DScAffiliations: From 1st IKA Hospital and “Attikon” University Hospital and Alfa Institute of Biomedical Sciences, Athens, Greece, and Tufts University School of Medicine, Boston, Massachusetts.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPoint-of-care Capillary Blood Lactate Measurements in Human Immunodeficiency Virus–uninfected Children With In Utero Exposure to Human Immunodeficiency Virus and Antiretroviral MedicationsCurrent awareness: Pharmacoepidemiology and drug safetyThalidomide- and Lenalidomide-Associated; Thromboembolism; NMS with Delayed Fever Associated with Risperidone Another Interesting Adverse Effect to Risperidone – Priapism; Hyperlactatemia due to Nevirapine; Recurrent Anaphylaxis with Gonadotropin-Releasing Hormone Analogs; Psychotropic Effects of Antiepileptic Drugs; Literacy and Misunderstanding of Prescription Drug Labels 5 December 2006Volume 145, Issue 11Page: 867-868KeywordsAntiretroviralsLactatesNucleosidesProtease inhibitorsResearch laboratoriesReverse transcriptase inhibitorsThiamineViral load ePublished: 5 December 2006 Issue Published: 5 December 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...