tbuckley/cabot-search huggingface dataset:
Tracking Early Readmission After Pancreatectomy to Index and Nonindex Institutions
Authors: Jeffrey J. Tosoian, Caitlin W. Hicks, John L. Cameron, Vicente Valero, Frederic E. Eckhauser, Kenzo Hirose, Martin A. Makary, Timothy M. Pawlik, Nita Ahuja, Matthew J. Weiss, Christopher L. Wolfgang
Journal: JAMA Surgery (2014)

Readmission after pancreatectomy is common, but few data compare patterns of readmission to index and nonindex hospitals.To evaluate the rate of readmission to index and nonindex institutions following pancreatectomy at a tertiary high-volume institution and to identify patient-level factors predictive of those readmissions.Retrospective analysis of a prospectively collected institutional database linked to statewide data of patients who underwent pancreatectomy at a tertiary care referral center between January 1, 2005, and December 2, 2010.Pancreatectomy.The primary outcome was unplanned 30-day readmission to index or nonindex hospitals. Risk factors and reasons for readmission were measured and compared by site using univariable and multivariable analyses.Among all 623 patients who underwent pancreatectomy during the study period, 134 (21.5%) were readmitted to our institution (105 [78.4%]) or to an outside institution (29 [21.6%]). Fifty-six patients (41.8%) were readmitted because of a gastrointestinal or nutritional problem related to surgery and 42 patients (31.3%) because of a postoperative infection. On multivariable analysis, factors independently associated with readmission included age 65 years or older (odds ratio [OR], 1.80; 95% CI, 1.19-2.71), preexisting liver disease (OR, 2.28; 95% CI, 1.23-4.24), distal pancreatectomy (OR, 1.77; 95% CI, 1.11-2.84), and postoperative drain placement (OR, 2.81; 95% CI, 1.00-7.14).In total, 21.5% of patients required early readmission after pancreatectomy. Even in the setting of a tertiary care referral center, 21.6% of these readmissions were to nonindex institutions. Specific patient-level factors were associated with an increased risk of readmission.
The Occurrence of Vascular Complications in Low Renin Hypertension.
Authors: Subhash C. Gulati
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973The Occurrence of Vascular Complications in Low Renin Hypertension.Subhash C. Gulati, M.D., E. Victor Adlin, M.D., F.A.C.P., C. Miller Biddle, M.D., Allan D. Marks, M.D., Bertram J. Channick, M.D., F.A.C.P.Subhash C. Gulati, M.D.Search for more papers by this author, E. Victor Adlin, M.D., F.A.C.P.Search for more papers by this author, C. Miller Biddle, M.D.Search for more papers by this author, Allan D. Marks, M.D.Search for more papers by this author, Bertram J. Channick, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-828_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo determine the relation of low plasma renin activity in hypertension to the development of vascular complications, 201 patients with essential hypertension, who had previously had measurements of plasma renin activity and aldosterone excretion rate, were surveyed for myocardial infarction or cerebrovascular accident. Patients with renovascular hypertension, malignant hypertension, and primary or secondary aldosteronism were excluded. Plasma renin activity was measured after the stimulus of upright posture plus a low sodium diet. One hundred and sixteen patients had normal activity and were diagnosed as having normal-renin essential hypertension. Eighty-five patients had low activity and were diagnosed as having low-renin essential... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Subhash C. Gulati, M.D.; E. Victor Adlin, M.D., F.A.C.P.; C. Miller Biddle, M.D.; Allan D. Marks, M.D.; Bertram J. Channick, M.D., F.A.C.P.Affiliations: Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byZur Pathogenese und Pathophysiologie der essentiellen HypertonieReninLow renin hypertension: A current review of definitions and controversiesUltrastructure of coronary arteries and myocardium in experimental hypertensionThe Renin-Angiotensin SystemRenin: A Risk Factor for Cardiovascular Disease?A. RICHARD CHRISTLIEB, M.D., F.A.C.P., RAY E. GLEASON, Ph.D., ROGER B. HICKLER, M.D., F.A.C.P., DAVID P. LAULER, M.D.Low-renin hypertensionLACK OF ASSOCIATION BETWEEN PLASMA-RENIN AND HISTORY OF HEART-ATTACK OR STROKE IN PATIENTS WITH ESSENTIAL HYPERTENSION 1 May 1973Volume 78, Issue 5Page: 828-828KeywordsAldosteroneDietExcretionHypertensionMyocardial infarctionPlasma renin activityPostural controlSodiumStroke ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
The Palmitoylation of Metastasis Suppressor KAI1/CD82 Is Important for Its Motility- and Invasiveness-Inhibitory Activity
Authors: Bin Zhou, Li Liu, Muralidhar Reddivari, Xin A. Zhang
Journal: Cancer Research (2004)

The cancer metastasis suppressor protein KAI1/CD82 is a member of the tetraspanin superfamily. Recent studies have demonstrated that tetraspanins are palmitoylated and that palmitoylation contributes to the organization of tetraspanin webs or tetraspanin-enriched microdomains. However, the effect of palmitoylation on tetraspanin-mediated cellular functions remains obscure. In this study, we found that tetraspanin KAI1/CD82 was palmitoylated when expressed in PC3 metastatic prostate cancer cells and that palmitoylation involved all of the cytoplasmic cysteine residues proximal to the plasma membrane. Notably, the palmitoylation-deficient KAI1/CD82 mutant largely reversed the wild-type KAI1/CD82's inhibitory effects on migration and invasion of PC3 cells. Also, palmitoylation regulates the subcellular distribution of KAI1/CD82 and its association with other tetraspanins, suggesting that the localized interaction of KAI1/CD82 with tetraspanin webs or tetraspanin-enriched microdomains is important for KAI1/CD82's motility-inhibitory activity. Moreover, we found that KAI1/CD82 palmitoylation affected motility-related subcellular events such as lamellipodia formation and actin cytoskeleton organization and that the alteration of these processes likely contributes to KAI1/CD82's inhibition of motility. Finally, the reversal of cell motility seen in the palmitoylation-deficient KAI1/CD82 mutant correlates with regaining of p130(CAS)-CrkII coupling, a signaling step important for KAI1/CD82's activity. Taken together, our results indicate that palmitoylation is crucial for the functional integrity of tetraspanin KAI1/CD82 during the suppression of cancer cell migration and invasion.
A comparison of mechanical and laser transmyocardial revascularization for induction of angiogenesis and arteriogenesis in chronically ischemic myocardium
Authors: G.Chad Hughes, Shankha S Biswas, Bangliang Yin, Dmitri V Baklanov, Brian H Annex, R.Edward Coleman, Timothy R DeGrado, Carolyn K Landolfo, Kevin P Landolfo, James E Lowe
Journal: Journal of the American College of Cardiology (2002)
Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens
Authors: Kazutoshi Aoyama, Motoko Koyama, Ken-ichi Matsuoka, Daigo Hashimoto, Tatsuo Ichinohe, Mine Harada, Koichi Akashi, Mitsune Tanimoto, Takanori Teshima
Journal: Blood (2009)
Cognitive empathy presupposes self-awareness: Evidence from phylogeny, ontogeny, neuropsychology, and mental illness
Authors: Gordon G. Gallup, Steven M. Platek
Journal: Behavioral and Brain Sciences (2002)

We argue that cognitive empathy and other instances of mental state attribution are a byproduct of self-awareness. Evidence is brought to bear on this proposition from comparative psychology, early child development, neuropsychology, and abnormal behavior.
Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease
Authors: Justin Wanek, Bruce Gaynes, Jennifer I. Lim, Robert Molokie, Mahnaz Shahidi
Journal: American Journal of Hematology (2013)

The known biophysical variations of hemoglobin (Hb) S and Hb C may result in hemodynamic differences between subjects with SS and SC disease. The purpose of this study was to measure and compare conjunctival hemodynamics between subjects with Hb SS and SC hemoglobinopathies. Image sequences of the conjunctival microcirculation were acquired in 9 healthy control subjects (Hb AA), 24 subjects with SC disease, and 18 subjects with SS disease, using a prototype imaging system. Diameter ( D ) and blood velocity ( V ) measurements were obtained in multiple venules of each subject. Data were categorized according to venule caliber by averaging V and D for venules with diameters less than (vessel size 1) or greater than (vessel size 2) 15 µm. V in vessel size 2 was significantly greater than V in vessel size 1 in the AA and SS groups ( P ≥ 0.009), but not in the SC group ( P = 0.1). V was significantly lower in the SC group as compared to the SS group ( P = 0.03). In AA and SS groups, V correlated with D ( P ≤ 0.005), but the correlation was not statistically significant in the SC group ( P = 0.08). V was inversely correlated with hematocrit in the SS group for large vessels ( P = 0.03); however, no significant correlation was found in the SC group ( P ≥ 0.2). Quantitative assessment of conjunctival microvascular hemodynamics in SS and SC disease may advance understanding of sickle cell disease pathophysiology and thereby improve therapeutic interventions. Am. J. Hematol. 88:661–664, 2013. © 2013 Wiley Periodicals, Inc.
ACE Inhibitors and Diabetic Nephropathy
Authors: Mark E Molitch
Journal: Diabetes Care (1994)

Nineteen-ninety-three was a banner year for the demonstration of beneficial effects of interventions on outcomes in patients with diabetes and, in particular, with diabetic nephropathy. The Collaborative Study Group studying the effects of treatment with angiotensinconverting enzyme (ACE) inhibitors on the progression of diabetic nephropathy reported strongly positive results (1), hard on the heels of the publication of the results of the Diabetes Control and Complications Trial (DCCT) (2).
Patients with psoriasis have elevated levels of serum eosinophil cationic protein and increased numbers of EG2 positive eosinophils in the duodenal stroma
Authors: G. MICHAËLSSON, W. KRAAZ, B. GERDÉN, E. HAGFORSEN, I.P. LUNDIN, L. LÖÖF, O. SJÖBERG, A. SCHEYNIUS
Journal: British Journal of Dermatology (1996)

The occurrence of EG2-positive (EG2+) eosinophils and IgE in biopsy specimens of duodenal mucosa and skin from 39 psoriasis patients was studied, with emphasis on the relation to serum eosinophil cationic protein (ECP), serum IgE and the presence or absence of serum IgA and IgG antigliadin antibodies. Psoriasis patients had significantly elevated serum levels of ECP even after exclusion of five of 37 sera which were Phadiatop positive. The elevated serum ECP was not associated with the presence of IgA or IgG antibodies to gliadin. After exclusion of Phadiatop positive sera the serum IgE values did not differ from those of a group of healthy blood donors. Patients with psoriasis had a pronounced increase of EG2+ cells in their duodenal stroma. Patients without antibodies to gliadin tended to have even more EG2+ cells than those with such antibodies and those with increased duodenal intraepithelial lymphocytes. IgE+ cells were present in most duodenal specimens, and in some specimens there were > 100 IgE+ cells/section. The number of EG2+ cells was increased in lesional skin and, in some patients, also in non-involved skin, but there was a more pronounced increase in EG2 reactivity in the duodenal than in the skin specimens. IgE reactivity was increased both in non-involved and involved skin and was significantly related to the number of IgE-positive cells in the duodenal stroma. The results of this study indicate that the gastrointestinal tract and the eosinophil granulocyte might be involved in psoriasis in a hitherto unknown way.
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)
Authors: Kinuko Hirose, Takeshi Inukai, Jiro Kikuchi, Yusuke Furukawa, Tomokatsu Ikawa, Hiroshi Kawamoto, S. Helen Oram, Berthold Göttgens, Nobutaka Kiyokawa, Yoshitaka Miyagawa, Hajime Okita, Koshi Akahane, Xiaochun Zhang, Itaru Kuroda, Hiroko Honna, Keiko Kagami, Kumiko Goi, Hidemitsu Kurosawa, A. Thomas Look, Hirotaka Matsui, Toshiya Inaba, Kanji Sugita
Journal: Blood (2010)
Pulmonary haemorrhage following renal transplantation.
Authors: G A Khan, P Klapper
Journal: Thorax (1995)

The case history is presented of a 32 year old black man who developed haemoptysis leading to pulmonary haemorrhage and bilateral pulmonary infiltrates. He was found to have Kaposi9s sarcoma of the lung with no evidence of skin or endobronchial lesions.
Contribution of functional KIR3DL1 to ankylosing spondylitis
Authors: Ivan V Zvyagin, Ilgar Z Mamedov, Olga V Britanova, Dmitriy B Staroverov, Evgeni L Nasonov, Anna G Bochkova, Anna V Chkalina, Alexei A Kotlobay, Dmitriy O Korostin, Denis V Rebrikov, Sergey Lukyanov, Yuri B Lebedev, Dmitriy M Chudakov
Journal: Cellular and Molecular Immunology (2010)
Further Observations on the Effect of Hydrogen Ion on the Pulmonary Circulation
Authors: RÉJANE M. HARVEY, YALE ENSON, RUDOLFO BETTI, MILENA L. LEWIS, DUDLEY F. ROCHESTER, M. IRENÉ FERRER
Journal: Circulation (1967)

The effects of an acutely induced and modest increase in blood hydrogen-ion concentration on pulmonary hemodynamics were studied in 15 patients with obstructive lung disease. Pulmonary arterial pressure rose when the blood hydrogen-ion concentration increased; this change was greater when the arterial oxyhemoglobin saturation was lower than 91%. The pressor response was independent of change in cardiac output, pulmonary blood volume, and left veno-atrial pressure and is ascribed to pulmonary arterial vaso-constriction. Increased concentration of hydrogen ion is a factor in the production of pulmonary hypertension in patients with chronic obstructive pulmonary disease. Since infusion of acid produced a marked increase in ventilation, the effects of voluntary hyperventilation on pulmonary hemodynamics were studied in three patients with similar pulmonary diseases. In these subjects pulmonary arterial pressure fell as ventilation was increased by a degree comparable to that which occurred during the infusion of acid.
Mutations in CEP290, which encodes a centrosomal protein, cause pleiotropic forms of Joubert syndrome
Authors: Enza Maria Valente, Jennifer L Silhavy, Francesco Brancati, Giuseppe Barrano, Suguna Rani Krishnaswami, Marco Castori, Madeline A Lancaster, Eugen Boltshauser, Loredana Boccone, Lihadh Al-Gazali, Elisa Fazzi, Sabrina Signorini, Carrie M Louie, Emanuele Bellacchio, Enrico Bertini, Bruno Dallapiccola, Joseph G Gleeson
Journal: Nature Genetics (2006)
Problems of Mothers in Management of Children with Diabetes
Authors: Carolyn Robinson Banion, Margaret Shandor Miles, Melba C Carter
Journal: Diabetes Care (1983)

This study was designed to determine which aspects of diabetic management were perceived by mothers of children with diabetes to be the most problematic. A secondary purpose was to explore how age and sex of the child, age at diagnosis, illness duration, marital status, and socioeconomic status of the mother were related to the mother's perception of problematic aspects of care. The 84 subjects in this study were asked to complete the Diabetic Management Concern Questionnaire, which measures concern about 11 dimensions of diabetes management, along with a personal-situational information sheet. Results indicated that the three dimensions classified by mothers as most problematic were future concerns, hypoglycemia, and diabetic control. The younger the child, the greater the maternal concern about hypoglycemic reactions and availability of help/support. The younger the child was at diagnosis, the more the mother was concerned with hypoglycemic reactions. A shorter duration of illness was related to concern about insulin injections. Subjects with lower socioeconomic status were concerned about finances, the availability of help/support, and the psychological stigma of diabetes. Single mothers were also concerned about financial aspects of management. There were no differences in concerns between mothers of boys and girls. Implications of the findings for clinical practice are presented.
Anthropometry, Glucose Tolerance, and Insulin Concentrations in Indian Children
Authors: Ghattu V. Krishnaveni, Jacqueline C. Hill, Samantha D. Leary, Sargoor R. Veena, Julia Saperia, Anandathirtha Saroja, Samuel C. Karat, Caroline H.D. Fall
Journal: Diabetes Care (2005)

OBJECTIVE—The purpose of this study was to test the hypothesis that the environment experienced by fetuses of mothers with gestational diabetes mellitus (GDM) and mothers with higher glucose concentrations that are in the normal range causes increased adiposity and altered glucose/insulin metabolism in childhood. RESEARCH DESIGN AND METHODS—Children (n = 630) whose mothers were tested for glucose tolerance during pregnancy had detailed anthropometry performed at birth and annually thereafter. At 5 years, plasma glucose and insulin concentrations were measured in the children (2-h oral glucose tolerance test) and their fathers (fasting samples only). RESULTS—Newborns of diabetic mothers (n = 41) were larger in all body measurements than control newborns (babies with nondiabetic parents). At 1 year, these differences had diminished and were not statistically significant. At 5 years, female offspring of diabetic mothers had larger subscapular and triceps skinfold thicknesses (P = 0.01) and higher 30- and 120-min insulin concentrations (P &amp;lt; 0.05) than control children. Offspring of diabetic fathers (n = 41) were lighter at birth than control children (P &amp;lt; 0.001); they showed no differences in anthropometry at 5 years. In control children, skinfold thickness and 30-min insulin concentrations were positively related to maternal insulin area under the curve, and skinfold thicknesses were related to paternal fasting insulin concentrations independently of the parents’ skinfold thickness and socioeconomic status. CONCLUSIONS—Maternal GDM is associated with adiposity and higher glucose and insulin concentrations in female offspring at 5 years. The absence of similar associations in offspring of diabetic fathers suggests a programming effect in the diabetic intrauterine environment. More research is needed to determine whether higher maternal glucose concentrations in the nondiabetic range have similar effects.
ABC of psychological medicine: The consultation
Authors: L. Gask
Journal: BMJ (2002)

The success of any consultation depends on how well the patient and doctor communicate with each other. There is now firm evidence linking the quality of this communication to clinical outcomes. 

The dual focus—Patients are not exclusively physically ill or exclusively emotionally distressed. Often they are both. At the start of a consultation it is usually not possible to distinguish between these states. It is the doctor's task to listen actively to the patient's story, seeking and noticing evidence for both physical illness and emotional distress.


Involving patients—Changes in society and health care in the past decade have resulted in real changes in what people expect from their doctors and in how doctors view patients. In addition, greater emphasis has been placed on the reduction of risk factors, with attempts to persuade people to take preventive action and avoid risks to health. Many patients want more information than they are given. They also want to take some part in deciding about their treatment in the light of its chances of success and any side effects. Some patients, of course, do not wish to participate in decision making; they would prefer their doctor to decide on a single course of action and to advise them accordingly. The skill lies in achieving the correct balance for each patient. 


Three functions of the medical consultation
1 Build the relationship
• Greet the patient warmly and by name	•  Active listening	
• Detect and respond to emotional issues	 	
		





2 Collect data
• Do not interrupt patient	•  Consider other factors	
• Elicit patient's explanatory model	•  Develop shared understanding	
		





3 Agree a management plan
• Provide information	•  Make links	
• Appropriate use of reassurance	•  Negotiate behaviour change	
• Negotiate a management plan		
		








A comprehensive model—The “three function” model for the medical encounter provides a template for the parallel functions of the clinical interview. This is now widely used in medical schools.
Excretion of 4-hydroxy-3 methoxy mandelic acid in cases of ulcerative colitis and diarrhoea of nervous origin
Authors: J. T. Wright, A. K. Das
Journal: Gut (1969)

Urinary excretion of 4-hydroxy-3 methoxy mandelic acid (VMA) was used as an index of catecholamine activity in 59 cases of ulcerative colitis compared with 59 controls and 18 cases of diarrhoea of nervous origin. No significant differences were observed between cases and controls but the level of VMA excretion was raised in nervous diarrhoea.
Fraud in Medical Research
Authors: Stanley L. Lee
Journal: JAMA (1984)

To  Editor.—  I am impelled to comment on  extensive report in MEDICAL NEWS 1 concerning  latest in an unfortunately growing body of literature on fraud in medical research.  Each episode is, of course, in itself disturbing. But there is one aspect of each episode that I find particularly troubling and about which I have seen no previous comment. I refer to  actual fate of  protagonist. In this latest instance, he is now in a second residency program... retraining as a critical care specialist. Elsewhere in  article, his is described as the harshest penalty  federal government has ever imposed on a researcher for falsifying data.  The relegation of a disgraced physician-investigator to  practice of medicine has become  norm in what  JAMA article calls the expanding annals of scientific fraud. It seems to me that  punishment is entirely inappropriate.  I have
The role of the kidneys in glucose homeostasis in type 2 diabetes: Clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors
Authors: John P.H. Wilding
Journal: Metabolism (2014)

<h2>Abstract</h2> The kidneys play an important role in regulating glucose homeostasis through utilization of glucose, gluconeogenesis, and glucose reabsorption via sodium glucose co-transporters (SGLTs) and glucose transporters. The renal threshold for glucose excretion (RT<sub>G</sub>) is increased in patients with type 2 diabetes mellitus (T2DM), possibly due to upregulation of SGLT2 and SGLT1 expression. The resulting increase in renal glucose reabsorption is thought to contribute to the maintenance of hyperglycemia in patients with T2DM. Selective SGLT2 inhibitors reduce the RT<sub>G</sub>, thereby increasing glucosuria, and have demonstrated favorable efficacy and safety in patients with T2DM inadequately controlled with diet and exercise and other glucose-lowering treatments.