tbuckley/cabot-search huggingface dataset:
SULFONAMIDE DERIVATIVES AND BACTERIAL CONTAMINATION OF STORED PLASMA
Authors: M. V. Veldee
Journal: JAMA (1942)

To the Editor:—  InThe Journal, February 14, appeared an article by Dr. Milan Novak entitled The Use of Sulfonamide Derivatives as a Solution to the Problem of Bacterial Contamination in Stored Plasma.        In view of the present interest in human plasma for use in both military and civilian medicine, Dr. Novak's report will attract widespread attention. Particularly is this true since so many laboratories and clinics are eagerly awaiting methods which offer simplification of the complicated and exacting procedures required for safely processing plasma. My attention was called to this report by the author's results being at wide variance with other available data. Because of the urgency of the problem, Dr. Margaret Pittman was assigned the task of checking Dr. Novak's work as nearly as could be done from reading his report. Dr. Pittman's report follows:  Two different experiments have been done, one with pooled liquid human plasma and
Targeting Pleural Carcinoma Cells with the Anti-EpCAM BiTE Antibody MT110 by Stimulating Microenvironment T Cells.
Authors: B. Mayer, J. Witthauer, H. Winter, I. Funke, P. Baeuerle, K. Jauch
Journal: Cancer Research (2009)

Abstract Rationale: Despite therapy, most patients with advanced breast cancer develop malignant pleural effusion (MPE) associated with short survival. Strikingly, the metastatic cancer cells are frequently hormon receptor negative and show a reduced Her2/neu expression compared to the corresponding primary tumors. Thus, new treatment strategies are urgently needed.Objectives: In the present study, the efficacy of the bispecific single-chain antibody MT110 targeting both the epithelial antigen EpCAM (CD326) and the T cell antigen CD3 was investigated ex vivo with MPE samples of breast cancer patients.Methods: Target antigen expression of MPE cells was analyzed by immunohistochemistry. Percentage of redirected target cell lysis by MT110 was determined by double staining of cells with 7-amino actinomycin and an anti-EpCAM antibody using FACS analysis. Activation of autologous CD4+ and CD8+ cells in response to MT110 was studied by expression of CD25 and granzyme B using FACS staining and different cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ) using ELISA analysis.Results: EpCAM+ cells were found in 14 out of 18 (78%) MPE samples from metastatic breast cancer patients. The fraction of EpCAM+ pleural carcinoma cells varied between 30% and 100% (mean 78%). CD3-positive cells were detected in all MPE samples ranging from 60% to 93% (mean 80%). Seven effusion samples were analyzed for MT110 treatment and revealed a dose-dependent and specific redirected lysis of EpCAM+ cells after 48h and 72h with 10 ng/ml (48h, 72h: p=0.03, respectively) and 1000 ng/ml (48h, p=0.03; 72h, p=0.016). After 72 h, 57% ± 29.5% (mean ± SD) of EpCAM+ cells were killed using 1000 ng/ml MT110. The ratio between effector (E) and target (T) cells revealed no influence on the extent of the redircted specific lysis. Antibody treatment increased the fraction of CD25/CD4 cells after 48h (p=0.03) and 72h (p=0.016). Similar, CD25 expression on CD8 cells was stimulated after 48h (p=0.03) and 72h (p=0.016) using 1000 ng/ml MT110. Cytokine analysis revealed a strong TH1 immune response detecting an increased TNFα (p=0.016) and IFNγ (p=0.03) secretion. Conclusion: Single-agent therapy with MT110 is capable of activating unstimulated autologous T cells for efficient and specific redirected lysis of EpCAM+ tumor cells in MPE from breast cancer patients. MPE revealed interindividual differences regarding the extent of specific lysis and the stimulation of the microenvironmental T cells. Thus, treatment with the bispecific antibody MT110 might by an option in the management of a subcohort of metastatic breast cancer patients. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4133.
US Health Policy in the Aftermath of Hurricane Katrina
Authors: Sara Rosenbaum
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
149 INSULIN-LIKE GROWTH FACTOR-I (IGF-I) REDUCES THE IMPACT OF AGE IN OXIDATIVE LIVER DAMAGE AND RESTORES INSULIN RESISTANCE AND LIPID METABOLISM
Authors: M. García-Fernández, J.E. Puche, G. Delgado, S. González-Barón, I. Castilla-Cortázar
Journal: Journal of Hepatology (2008)
Abstract 13421: Prognostic Significance of QRS-T Angle in Middle-Aged General Population
Authors: Olli Anttonen, Jani T Tikkanen, Aapo L Aro, Juhani M Juntila, Tuomas Kerola, Harri A Rissanen, Antti Reunanen, Heikki V Huikuri
Journal: Circulation (2010)

Introduction: QRS-T angle (either planar or spatial) measured from a standard 12-lead electrocardiogram (ECG) has been shown to predict mortality in various patient and general populations. Because...
A New Direction in Rehabilitation Through Advanced Instrumentation and Computation
Authors: Theodor D. Sterling
Journal: JAMA (1967)

The development of instruments to aid individuals with serious motor or sensory problems or both has always played an important part in rehabilitation work. With the additional ability for logical processing of information presented by a computer or by what might be more properly referred to as logic circuitry, a new dimension has been added to the concept of "aid" which may represent an important guideline to the thinking of the therapist. Yet the role of processing or computation in the instrumentation field is as yet neither appreciated nor, frankly, very well understood. The dominant source of confusion appears to be the general misunderstanding concerning what computers are and what they do. In the minds of many individuals, computers are still exclusively identified as instruments that do calculations, such as slide rules or desk calculators. While it is true that computers do calculate, the actual amount of time spent in
Antiplatelet Therapy and Stent Thrombosis After Sirolimus-Eluting Stent Implantation
Authors: Takeshi Kimura, Takeshi Morimoto, Yoshihisa Nakagawa, Toshihiro Tamura, Kazushige Kadota, Hitoshi Yasumoto, Hideo Nishikawa, Yoshikazu Hiasa, Toshiya Muramatsu, Taiichiro Meguro, Naoto Inoue, Hidehiko Honda, Yasuhiko Hayashi, Shunichi Miyazaki, Shigeru Oshima, Takashi Honda, Nobuo Shiode, Masanobu Namura, Takahito Sone, Masakiyo Nobuyoshi, Toru Kita, Kazuaki Mitsudo
Journal: Circulation (2009)

Background— The influences of antiplatelet therapy discontinuation on the risk of stent thrombosis and long-term clinical outcomes after drug-eluting stent implantation have not yet been addressed adequately. Methods and Results— In an observational study in Japan, 2-year outcomes were assessed in 10 778 patients undergoing sirolimus-eluting stent implantation. Data on status of antiplatelet therapy during follow-up were collected prospectively. Incidences of definite stent thrombosis were 0.34% at 30 days, 0.54% at 1 year, and 0.77% at 2 years. Thienopyridine use was maintained in 97%, 62%, and 50% of patients at 30 days, 1 year, and 2 years, respectively. Patients who discontinued both thienopyridine and aspirin had a significantly higher rate of stent thrombosis than those who continued both in the intervals of 31 to 180 days, 181 to 365 days, and 366 to 548 days after stent implantation (1.76% versus 0.1%, P &lt;0.001; 0.72% versus 0.07%, P =0.02; and 2.1% versus 0.14%, P =0.004, respectively). When discontinuation of aspirin was taken into account, patients who discontinued thienopyridine only did not have an excess of stent thrombosis in any of the time intervals studied. Adjusted rates of death or myocardial infarction at 24 months were 4.1% for patients taking thienopyridine and 4.1% for patients not taking thienopyridine ( P =0.99) in the 6-month landmark analysis. Conclusions— Discontinuation of both thienopyridine and aspirin, but not discontinuation of thienopyridine therapy only, was associated with an increased risk of stent thrombosis. Landmark analysis did not suggest an apparent clinical benefit of thienopyridine use beyond 6 months after sirolimus-eluting stent implantation.
Left ventricular pressure-diameter relations in the conscious rabbit
Authors: N. GILSON, B. CROZATIER, M. LAPLACE
Journal: Cardiovascular Research (1989)

A model for the study of left ventricular (LV) contractility in a small species was developed using conscious rabbits previously instrumented with a LV catheter and ultrasonic crystals measuring LV internal diameter. Afterload increase produced by methoxamine infusion was associated with a reduction in heart rate from 272(SEM18) to 214(20) beats·min−1, p<0.01; and an increase in LV end systolic pressure from 76.3(4.1) to 101(6.5) mm Hg, p<0.001, and in end systolic diameter from 8.7(0.7) to 9.9(0.7) mm, p<0.01. For matched end systolic pressure and heart rate, the increase in inotropic state produced by noradrenaline infusion significantly shifted the pressure-diameter relation to the left. Similarly, end systolic pressure and diameter were significantly lowered by sodium nitroprusside infusion, with a reflex increase of heart rate; and a decrease in inotropic state produced by verapamil infusion was demonstrated by a significantly larger end systolic diameter for matched end systolic pressure and heart rate. The pressure-diameter relation was not modified by volume loading, which increased end diastolic diameter by 9.6(1.1) % with no evidence of a Bainbridge reflex. The mild depressant effect of diltiazem was not detected by peak dP/dt changes but was demonstrated by the analysis of end systolic pressure-diameter relations. The instrumented rabbit thus appears to be a sensitive model for studying LV function and the cardiovascular effects of drugs.
Blue Light and Milk
Authors: Alice M. Godfrey
Journal: Annals of Internal Medicine (2002)

Letters16 July 2002Blue Light and MilkAlice M. Godfrey, MDAlice M. Godfrey, MDAptos, CA 95003 (Godfrey)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-2-200207160-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I am an enthusiastic reader of “On Being a Doctor,” which is usually the first section I turn to in Annals. These essays have consistently described experiences and insights that were interesting, original, and thought provoking. My disappointment in the essay “Blue Light and Milk” (1) was therefore acute. This memoir struck me as sentimental and self-indulgent and the language as both trite and pretentious. I have no doubt that Dr. Morowitz is a warm, loving, and totally admirable father, but his reminiscences would have been more appropriate in a parenting magazine than in Annals of Internal ...Reference1. Morowitz DA. Blue light and milk. Ann Intern Med. 2001;134:1148-9. [PMID: 11412057] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Alice M. Godfrey, MDAffiliations: Aptos, CA 95003 (Godfrey) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBlue Light and Milk David A. Morowitz Metrics 16 July 2002Volume 137, Issue 2Page: 143KeywordsMilk ePublished: 16 July 2002 Issue Published: 16 July 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Specific serological diagnosis of viral hepatitis.
Authors: A J Zuckerman
Journal: BMJ (1979)

<h3>Background</h3> This study describes characteristics and outcomes of AAV patients included in a nation-wide initiative collecting clinical and laboratory data since 2009. <h3>Methods</h3> Sixteen vasculitis centres (9x Nephrology, 4x Rheumatology, 2x Immunology, 1x Pediatrics) have participated in web-based data collection, consisting of retrospective data supplied at entry and prospective follow-up with a visit recorded every 3-6 months. Statistical analysis included the Kaplan-Meier method and log-rank test for survival analysis. <h3>Results</h3> A total of 681 patients (M/F 326/355, median age at diagnosis 58, range 11-89 years) were enrolled (168pts are newly diagnosed), 338 (50%) c ANCA positive, 236 p ANCA (35%), 24 (4%) ANCA negative and 72 (11%) was not investigated. The mean time from diagnosis was 71 months (range 0-475). GPA was the most common diagnosis with 58%, followed by MPA (including renal-limited form) recorded in 35% and EGPA in 4%. Cumulative organ involvement involved kidney in 83% (confirmed with renal biopsy in 72% of them), lungs in 55% joint 35% and ENT in 34%. Most (88%) pts received cyclophosphamide, azathioprine was used in 60%,mycophenolate mophetil or acid in 24%, methotrexate in 2%, 35% of patients underwent PLEX. To cope with disease activity 35 pts (4%) were treated with biological therapies, most of them (27) by rituximab. At present 512 pts are alive, pts status is assessed as complete remission in 72%, partial remission in 12%, persistent activity in 6%, primo-manifestation - new activity in 3% and relapse in 7%. Most (98%) pts. have hypertension (85% are treated by ACEi), 14 (2%) pts are post kidney Tx, 14% are dependent on dialysis. Last available VDI (Vasculitis Damage Index) ranged between 0 and 16 (median 4). The estimated 5-year survival was 81.5% (95% CI =78.1% - 84.9%) and was significantly higher in patients with ENT involvement compared to those without (p&lt;0.001), but significantly lower in patients with lung involvement compared to those without (p&lt;0.01). Significant differences were found in the estimated survival of patients stratified according to the disease severity at diagnosis (localized &gt; early systemic &gt; generalized &gt; severe renal). <h3>Conclusions</h3> In the Czech population, GPA is the most common AAV, reflecting the northern European type.The disease severity at the diagnosisi is associated with higher mortality. <i>Supported by the Czech Kidney Foundation</i> <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5777
Antiangiogenesis and Drug Delivery to Tumors: Bench to Bedside and Back
Authors: Dan G. Duda
Journal: Cancer Research (2006)

After over 30 years of preclinical and clinical development, antiangiogenic agents have recently entered the clinic as attractive targeted therapeutics for the treatment of cancer. Fueled by exciting new developments in the field, the AACR Special Conference was designed to broadly survey critical scientific advances in the antiangiogenic therapy of cancer. Because these advances have come primarily with the use of combinations of antiangiogenic agents with chemotherapy, or with antiangiogenic agents that also directly target the cancer cells, the central theme included the issue of drug delivery to tumors. These two major issues were addressed in concert, from basic mechanisms of action of antiangiogenic agents to new combination approaches to cancer treatment. Nearly 300 participants from 20 countries registered for the conference, drawn both from academia and industry, with a wide range in experience and background. Dr. Rakesh Jain, along with conference co-chairs, Drs. Lee Ellis and Luisa Iruela-Arispe, assembled an outstanding lineup of speakers for this conference that included many of the pioneers in the fields of angiogenesis and drug delivery from the U.S. and abroad. This resulted in an excellent overview of the advances in our understanding of cellular and molecular aspects of tumor angiogenesis and antiangiogenic therapy of cancer in combination with conventional therapy.
A. M. A. Week Clinics.
Authors: J. F. Baldwin
Journal: JAMA (1899)

Columbus, Ohio, Aug. 5, 1899. <h3>To the Editor.</h3> —During the week of the meeting of theAssociationin Columbus, I made a number of private abdominal sections. Although there were no public clinics, all the operations were witnessed by numbers of my surgical colleagues who had honored me by asking to see me work. Several of them requested to be informed of the results of the operations, but as I am unable to keep a record of my visitors I have felt that the only way to reach them would be by a note to theJournal. The abdominal sections were twelve in number, ten of the cases being operated on at the Protestant Hospital and two at St. Anthony. I am happy to state that in all the cases recovery was absolutely uneventful and the patients all left the hospital promptly and in good condition. Very respectfully,
Strangulated Diaphragmatic Hernia Complicating Pregnancy
Authors: George A. Bourgeois, Wilfred T. Hood
Journal: New England Journal of Medicine (1949)

DIAPHRAGMATIC hernia is not a rare complication of pregnancy. By roentgenologic examination Rigler and Eneboe1 demonstrated this condition in 25, or 12.8 per cent, of 195 women in the last trimester of pregnancy; in 4, or 5.1 per cent, of 71 primiparas; and in 21, or 18.1 per cent, of 116 multiparas. They reached the conclusions that diaphragmatic hernia is commoner in the female than in the male, that its incidence increases with age and repeated pregnancy and that increased intra-abdominal pressure is an important etiologic factor. Mengert and Murphy2 showed that intra-abdominal pressure is increased by voluntary muscular effort . . .
Patient-Identified Needs for Hormone Replacement Therapy Counseling: A Qualitative Study
Authors: Maureen T. Connelly, Nancy Ferrari, Nicole Hagen, Thomas S. Inui
Journal: Annals of Internal Medicine (1999)

Background: Numerous medical organizations, including the American College of Physicians, have recommended that women be counseled about postmenopausal hormone replacement therapy (HRT). Patients' perspectives on their counseling needs, however, have not been integrated into most counseling guides. Objective: To use patient self-reports to identify needs for HRT counseling. Design: Individual, in-depth patient interviews. Setting: Managed care organization. Patients: 26 women who had received an initial prescription for HRT. Measurements: Qualitative, consensus review of the content of interview transcripts. Results: On average, women reported 15 factors (range, 6 to 24 factors) as critical to their decision-making process. Although most women cited their physician's opinion (96%), reports in the media (81%), and experiences and opinions of friends (77%) as critical to their decisions about HRT, counseling recommendations address none of these concerns. Conclusions: Many women in a managed care organization who accepted a prescription for HRT identified counseling needs that are not included in widely used HRT guidelines.
Points: Managing flying phobia
Authors: R. F Crellin, L. M Drummond
Journal: BMJ (1988)

gresses more rapidly in this group is in dispute.Although we are unlikely to find premalignant disease in the sexually active girls under 16, we think that cytological screening is useful to educate them about the need for regular cervical smears.These patients are likely to have many sexual partners, have a high prevalence of sexually trans- mitted diseases (770/o-A J Robinson, unpublished data), and be at high risk of developing cervical intraepithelial neoplasia.
Interferon γ–independent Rejection of Interleukin 12–transduced Carcinoma Cells Requires CD4+ T Cells and Granulocyte/Macrophage Colony–stimulating Factor
Authors: Chiara Zilocchi, Antonella Stoppacciaro, Claudia Chiodoni, Mariella Parenza, Nadia Terrazzini, Mario P. Colombo
Journal: The Journal of Experimental Medicine (1998)

We analyzed the ability of interferon (IFN)-γ knockout mice (GKO) to reject a colon carcinoma transduced with interleukin (IL)-12 genes (C26/IL-12). Although the absence of IFN-γ impaired the early response and reduced the time to tumor onset in GKO mice, the overall tumor take rate was similar to that of BALB/c mice. In GKO mice, C26/IL-12 tumors had a reduced number of infiltrating leukocytes, especially CD8 and natural killer cells. Analysis of the tumor site, draining nodes, and spleens of GKO mice revealed reduced expression of IFN- inducible protein 10 and monokine induced by γ-IFN. Despite these defects, GKO mice that rejected C26/IL-12 tumor, and mice that were primed in vivo with irradiated C26/IL-12 cells, showed the same cytotoxic T lymphocyte activity but higher production of granulocyte/macrophage colony–stimulating factor (GM-CSF) as compared with control BALB/c mice. Treatment with monoclonal antibodies against GM-CSF abrogated tumor regression in GKO but not in BALB/c mice. CD4 T lymphocytes, which proved unnecessary or suppressive during rejection of C26/IL-12 cells in BALB/c mice, were required for tumor rejection in GKO mice. CD4 T cell depletion was coupled with a decline in GM-CSF expression by lymphocytes infiltrating the tumors or in the draining nodes, and with the reduction and disappearance of granulocytes and CD8 T cells, respectively, in tumor nodules. These results suggest that GM-CSF can substitute for IFN-γ in maintaining the CD8–polymorphonuclear leukocyte cross-talk that is a hallmark of tumor rejection.
Report clears Labour party of fault in purchase of vaccines
Authors: Zosia Kmietowicz
Journal: BMJ (2004)

The Department of Health has been criticised for delays in upgrading the way it procures vaccines, which have cost the NHS an estimated £25m ($44m, €37m) in the past three years.

But it has been cleared of any wrongdoing in awarding a £32.5m contract to a pharmaceutical company at a time when the chief executive made a £100 000 donation to the Labour party.

The department had been aware of deficiencies in its procurement procedures since they were first highlighted in an internal audit conducted in 1997, says a report from the House of Commons Committee of Public Accounts. But it took three further internal reviews over …
Protect Eyes From Ultraviolet Light to Prevent Cataract Rather Than Retinal Damage
Authors: Hugh R. Taylor
Journal: JAMA (1989)

To the Editor.—  I read with much interest the informative report by Dr Olson 1 on the potential threat of ozone depletion to the eye. The report clearly highlights the problems associated with the selection of sunglasses that adequately protect against ultraviolet (UV) light. Although the report indicates the uncertainties in the relationship between exposure to UV light and retinal disease, including macular degeneration, attention should also be drawn to the recent work 2,3 that has quantified the harmful effects exposure to UV-B light has on the crystalline lens. Unlike the unsubstantiated relationship for retinal damage, the association between exposure to UV-B light and cataracts has now been well established and warrants proper attention. For cortical cataract, for example, a doubling of ocular exposure leads to a 60% increase in risk, and those with exposure above the median have more than three times the risk of those with exposure in