tbuckley/cabot-search huggingface dataset:
BROMIDE INTOXICATION TREATED WITH ETHACRYNIC ACID
Authors: JOHN E. SELISKAR
Journal: Annals of Internal Medicine (1966)

Letters and Comments1 December 1966BROMIDE INTOXICATION TREATED WITH ETHACRYNIC ACIDJOHN E. SELISKAR, M.D., KARL H. SHIPMAN, M.D., HERBERT B. KENNISON JR., M.D.JOHN E. SELISKAR, M.D.Search for more papers by this author, KARL H. SHIPMAN, M.D.Search for more papers by this author, HERBERT B. KENNISON JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1341 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We have recently successfully treated a patient with bromide intoxication with ethacrynic acid and should like to add our experience to that using ethacrynic acid and mannitol as reported by Adamson, Flanigan, and Ackerman in the October issue of the ANNALS.A 55-year-old white woman entered the hospital on April 22, 1966, in a confused state. She was unable to speak intelligibly, and the history was given by her estranged spouse. She had become nervous and depressed in recent months and had begun taking a sedative later found to be a bromine-containing "nerve" compound. She had been...References1. LEDINGHAMBAYLISS JGRI: Metabolic effects and site of action of ethacrynic acid. Clin. Pharmacol. Ther. 6: 474, 1965. CrossrefMedlineGoogle Scholar2. BRESTONESTISELLERRAMIREZHEIDERMOYER ANGROCJH: Pharmacodynamic effects of a new diuretic drug, ethacrynic acid. Amer. J. Cardiol. 16: 99, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN E. SELISKAR, M.D.; KARL H. SHIPMAN, M.D.; HERBERT B. KENNISONJR., M.D.Affiliations: Department of Medicine Presbyterian Medical Center Denver, Colo. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Toxicology of Bromide Ion 1 December 1966Volume 65, Issue 6Page: 1341-1342KeywordsIntoxicationMannitolNervesSedatives ePublished: 1 December 2008 Issue Published: 1 December 1966 PDF downloadLoading ...
NADPH oxidases: New kids on the block
Authors: M GEISZT
Journal: Cardiovascular Research (2006)

Reactive oxygen species (ROS) play a pivotal role in many physiological processes including host defense, hormone biosynthesis, fertilization and cellular signaling. Altered production of ROS has been implicated in the development of immunodeficiency, hypothyroidism and cardiovascular pathologies. In the last few years, several enzymes were identified at the molecular level, which are now thought to be responsible for ROS production observed in diverse tissues. These enzymes show a high degree of homology to the phagocytic NADPH oxidase and are now designated the Nox family of NADPH oxidases. This review updates our knowledge on six new members of the Nox family: Nox1, Nox3, Nox4, Nox5, Duox1 and Duox2.
Chromosome damage after intra-articular injections of radioactive yttrium. Effect of immobilization on the biological dose.
Authors: A de la Chapelle, A Rekonen, M Oka, A Ruotsi
Journal: Annals of the Rheumatic Diseases (1972)

The future of this kind of radiotherapy is largely dependent on whether the ionizing radiation has side-effects.Chromosome damage in patients who had received intra-articular injections of radioactive gold ('98Au) has recently been reported (Stevenson, Bedford, Hill, and Hill, 1971a).At present radioactive yttrium (90Y) is displacing 19"Au as an agent for radiation synovectomy.In radiophysical characteristics 90Y is clearly superior to '98Au.It emits only beta-rays with a high maximum energy (2.25 MeV) and a maximum range in the tissue of 11 mm.(average 4 mm.).The corresponding figures for 198Au indicate that it is much less effective.The two isotopes have the same half-life, 2-7 days.
Anti-Apoptosis Mechanisms in Malignant Gliomas
Authors: David S. Ziegler, Andrew L. Kung, Mark W. Kieran
Journal: Journal of Clinical Oncology (2008)

Malignant gliomas are characterized by an intrinsic resistance to apoptosis. Increasing evidence suggests that this is a fundamental mechanism by which gliomas evade elimination when treated with both conventional and targeted therapies. In this review, we describe the multiple anti-apoptotic signals that have been demonstrated to be active in malignant gliomas. We describe the preclinical evidence that suggests that targeting those signaling anomalies can increase tumor responsiveness and enhance the elimination of gliomas in preclinical models. We discuss recent advances in translating pro-apoptotic compounds to clinical trial, and the potential for implementing agents that target the apoptotic pathway as a strategy for improving the outcomes for patients with high-grade gliomas.
Patients' groups welcome NICE decisions on arthritis and multiple sclerosis drugs
Authors: Andrew Cole
Journal: BMJ (2007)

Patients' groups have welcomed the decision by the National Institute for Health and Clinical Excellence (NICE) to give the go ahead to two new drugs for arthritis and one for multiple sclerosis.

NICE has approved for use in the NHS in England and Wales rituximab (MabThera) for severe active rheumatoid arthritis and adalimumab (Humira) for active and progressive psoriatic arthritis. It also recommended natalizumab (Tysabri) to treat rapidly evolving, severe relapsing-remitting multiple sclerosis.

Rituximab in combination with methotrexate will be available to NHS patients who have failed to respond to other antirheumatoid drugs, including at least one tumour necrosis …
The Treatment of Chronic Ringworm of the Scalp: A New Method of Epilating the Diseased Hairs
Authors: M. Morris
Journal: BMJ (1882)

LECTURE V.-FAMILY MYRMECOPHAGIDE.TuIE animals constituting this family are externally clothed with hair.They have no teeth.The mouth is tubular, with a small terminal aperture, through which the long vermiform tongue, covered with the viscid secretion of the enormous submaxillary glands, is rapidly pro- truded in feeding, and withdrawn again with the adhering particles of aliment, which are then sucked into the pharynx.^In the manus, the third toe is greatly developed, and has a long falcate claw; the others are reduced or suppressed.The pes has four or five subequal digits with claws.The posterior dorsal and lumbar vertebrae have additional interlocking zygapophyses.The tail is long, and sometimes prehensile.The placenta is subdiscoidal or dome-like, and apparently deciduate as in the sloths; and the penis is rudimentary.The mamma are two, pectoral.The animals of this family are the Anteaters par excellence.They
Advances in cardiac imaging: the role of magnetic resonance imaging and computed tomography in identifying athletes at risk
Authors: N H Prakken, B K Velthuis, M J Cramer, A Mosterd
Journal: British Journal of Sports Medicine (2009)

Advanced cardiac imaging, using cardiac magnetic resonance imaging (MRI) and multidetector computed tomography (CT), is increasingly used in the work-up of athletes with suspected abnormalities on screening. Both imaging modalities produce highly accurate and reproducible structural and functional cardiac information. Cardiac MRI has the advantage of imaging without radiation exposure or the use of iodine-containing contrast agents, but is sometimes not possible due to claustrophobia or other contraindications. Although cardiac MRI can rule out coronary artery anomalies, multidetector CT is superior to cardiac MRI for visualising the full extent of the coronary arteries and atherosclerotic coronary artery disease. For patients less than 35 years of age, cardiac MRI is the first option after initial echocardiography for further assessment of cardiomyopathies, myocarditis and coronary anomalies, which are major causes of sudden cardiac death in young athletes. For athletes over 35 years of age the most common cause of sudden cardiac death is coronary artery disease, whereby cardiovascular screening requires further diagnostic modalities and may include multidetector CT.
GALT Protein Database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-Related Protein and Its Mutants
Authors: Antonio d’Acierno, Angelo Facchiano, Anna Marabotti
Journal: Genomics Proteomics & Bioinformatics (2009)

We describe the GALT-Prot database and its related web-based application that have been developed to collect information about the structural and functional effects of mutations on the human enzyme galactose-1-phosphate uridyltransferase (GALT) involved in the genetic disease named galactosemia type I. Besides a list of missense mutations at gene and protein sequence levels, GALT-Prot reports the analysis results of mutant GALT structures. In addition to the structural information about the wild-type enzyme, the database also includes structures of over 100 single point mutants simulated by means of a computational procedure, and the analysis to each mutant was made with several bioinformatics programs in order to investigate the effect of the mutations. The web-based interface allows querying of the database, and several links are also provided in order to guarantee a high integration with other resources already present on the web. Moreover, the architecture of the database and the web application is flexible and can be easily adapted to store data related to other proteins with point mutations. GALT-Prot is freely available at http://bioinformatica.isa.cnr.it/GALT/.
The 'Grand Conspiracy' Against the Cancer Cure
Authors: William Regelson
Journal: JAMA (1980)

IN BOTH randomized double-blind and nonrandomized studies, our group and others have tested hydrazine sulfate in advanced-stage cancer patients and found it to have little value.<sup>1-4</sup>If our clinical impressions are true, why does publicity engendered by<i>Penthouse</i>magazine, Gold,<sup>5</sup>and Russian reports<sup>6-8</sup>as to hydrazine's value contradict our experience? I first heard of hydrazine from Joseph Gold, MD, of the Syracuse Cancer Research Institute in the spring of 1973. To his credit, the use of hydrazine was based on his original concept that the glycolysis of cancer cells and the presence of cancer stimulated gluconeogenesis, which constituted a systemic metabolic circuit capable of drawing substantial amounts of energy from the cancer host.<sup>9-10</sup>Dr Gold postulated that this mechanism of energy loss was responsible for cancer cachexia, which he believed could be reversed by metabolically interrupting gluconeogenesis. Based on Gold's<sup>11,12</sup>concept that he could reverse
Costs and Charges Associated with Three Alternative Techniques of Hysterectomy
Authors: James H. Dorsey, Patrice M. Holtz, Robert I. Griffiths, Margaret M. McGrath, Earl P. Steinberg
Journal: New England Journal of Medicine (1996)

Many hysterectomies are now performed by a laparoscopically assisted vaginal technique. This procedure is controversial, partly because of concern about cost. We studied hospital charges and costs for the procedure as compared with those for total abdominal hysterectomy and total vaginal hysterectomy in clinically similar groups of patients.
Patients' views of the good doctor
Authors: A. Coulter
Journal: BMJ (2002)

<h3>Abstract</h3> Multicellular life processes such as proliferation and differentiation depend on cell surface signaling receptors that bind ligands generally referred to as growth factors. Recently, it has emerged that the endosomal system provides rich signal processing capabilities for responses elicited by these factors [1-3]. At the single cell level, endosomal trafficking becomes a critical component of signal processing, as exemplified by the epidermal growth factor (EGF) receptors of the receptor tyrosine kinase family. EGFRs, once activated by EGF, are robustly trafficked to the phosphatase-enriched peri-nuclear region (PNR), where they are dephosphorylated [4-8]. However, the details of the mechanisms regulating the movements of stimulated EGFR in time and space, i.e., towards the PNR, are not known. What endosomal regulators provide specificity to EGFR? Do modifications to the receptor upon stimulation regulate its trafficking? To understand the events leading to EGFR translocation, and especially the early endosomal dynamics that immediately follow EGFR internalization, requires the real-time, long-term, whole-cell imaging of multiple elements. Here, exploiting the advantages of lattice light-sheet microscopy [9], we show that the binding of EGF by its receptor, EGFR, triggers a transient calcium increase that peaks by 30 s, causing the desorption of Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) from pre-existing endosomes within one minute, the rebinding of liberated APPL1 to EGFR within three minutes, and the dynein-dependent translocation of APPL1-EGF-bearing endosomes to the PNR within five minutes. The novel, cell spanning, fast acting network that we reveal integrates a cascade of events dedicated to the cohort movement of activated EGFR receptors. Our findings support the intriguing proposal that certain endosomal pathways have shed some of the stochastic strategies of traditional trafficking, and have evolved behaviors whose predictability is better suited to signaling [10, 11]. Work presented here demonstrates that our whole cell imaging approach can be a powerful tool in revealing critical transient interactions in key cellular processes such as receptor trafficking.
Sequential FDG PET and MRI Findings in a Case of Human Herpes Virus 6 Limbic Encephalitis
Authors: Fabrice Hubele, Karin Bilger, Stéphane Kremer, Alessio Imperiale, Bruno Lioure, Izzie Jacques Namer
Journal: Clinical Nuclear Medicine (2012)

A 50-year-old woman developed a human herpes virus 6 limbic encephalitis characterized by memory loss and somnolence, 3 weeks after a cord blood–derived stem cell transplantation. Sequential scalp electroencephalogram failed to detect seizure activity. Cerebrospinal fluid polymerase chain reaction assay demonstrated human herpes virus 6 deoxyribonucleic acid (positive, 3.74 log). Acute phase FDG PET imaging showed bilateral intense FDG uptake in both hippocampi and amygdalae. After antiviral treatment (gancyclovir followed by foscarnet), neurologic symptoms disappear gradually. Late phase FDG PET imaging showed a regression in FDG uptake representing hippocampal hypometabolism because of hippocampal sclerosis.
Premature Termination of Clinical Trials
Authors: Eric P Brass
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Cigarette Smoking on Dogs
Authors: E. C. Hammond, O. Auerbach, D. Kirman, L. Garfinkel
Journal: CA A Cancer Journal for Clinicians (1971)

Due to limitations of space, many of the details given in the original papers are necessarily omitted.Some of the photo micrographs originally published in black and white are shown here in color.In numerous epidemiologic and his tologic studies, it has been found that the harmful effects of cigarette smok ing increase with increasing dosage.Thus, if tar and nicotine are largely responsible for the damage, it may be postulated that reducing tar and nico tine by means of a filter will reduce the degree of damage produced by smoking any specified number of ciga rettes.The present study was under taken to test this hypothesis experi mentally.
The Treatment of Chemical Dependence-Reply
Authors: Roger D. Weiss
Journal: JAMA (1989)

In Reply. —  I appreciate and concur with the comment by Dr Clark regarding the need to employ a primary disease model in the treatment of chemically dependent patients. However, I must disagree with some of his other statements. For example, he says that  in the treatment of cocaine addiction is useful only for a short time after cocaine withdrawal. There is no evidence in the research literature that either supports or refutes this categorical statement, since the use of desipramine in cocaine abusers for anything except initiation of abstinence has never been studied systematically. Because desipramine is currently in widespread use in substance abuse treatment centers around the country, it seems critical to identify both the utility and the limits of this drug in the treatment of cocaine-dependent patients. This is the first report, to my knowledge, that identifies specific circumstances in which the use of desipramine might
Abstract 4705: MicroRNA-122 regulates liver metabolism and hepatocyte differentiation
Authors: Ann-Ping Tsou, Wei-Chih Tsai, Sheng-Da Hsu, Chu-Sui Hsu, Ming-Shi Hsiao, Shu-Jen Chen, Michael Hsiao, Hsien-Da Huang
Journal: Cancer Research (2011)

Abstract MicroRNAs (miRNAs), inhibitors of gene expression, participate in diverse biological functions and in carcinogenesis. MicroRNA-122, a liver-specific miRNA, is known to regulate lipid metabolism and tumorgenesis and is down-regulated in the intrahepatic metastastic HCC. To obtain insights into the physiological function of miR-122, we successfully generated the mir-122-/- mutant mouse (122KO). 122KO mice are viable with reduced serum cholesterol, elevated alkaline phosphatase and portal infiltration. Collagen deposition suggested minor fibrosis in 122KO livers. 122KO mice have distinctly different lipid metabolism. The levels of cholesterol and triglyceride are low in serum but high in liver tissue. Lipoprotein analysis revealed that 122KO mice have defect in VLDL transport. These results indicate that mir-122 deletion generated pathological features reminiscent that of nonalcoholic fatty liver disease (NAFLD) in human. In addition, mir-122 deletion is also prone to hepatocarcinogenesis. Liver tumors developed at age of 11 months in 5/5 mice. Expression of many genes was affected by mir-122 deletion. Pronounced changes are found in genes contributing to inflammation, cholestasis, fetal antigens, loss-of-imprinting and most importantly, expression of genes for metabolism of lipid and carbonhydrate are downregulated. The drastic change of transcriptome likely contributes to the pathological features presented in mir-122 knockout mice. We believe that 122KO mouse is a potential model for human HCC. This mouse model will provide a great opportunity to evaluate the physiological functions of mir-122 in hepatocyte differentiation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4705. doi:10.1158/1538-7445.AM2011-4705
P3-07-01: Are the Findings of ASOCOG Z0011 Applicable to District General Hospital Breast Unit – And How Should They Change Our Practice?
Authors: SB Olsen, B Amr, A Omar, J Smith, S Thomson, S Monib, LM Lai
Journal: Cancer Research (2011)

Abstract Background: There has been considerable debate on the management of the axilla in breast cancer patients with lymph node metastasis found on sentinel lymph node biopsy (SLNB) following publication of the ACOSOG Z0011 study. This study conclude that axillary lymph node dissection (ALND) does not add any benefit to overall and disease free survival in some patients with positive SLNB. However it is not know if the patient characteristics of this study are transferable to other settings. A previous UK study has suggested that only a minority of patients from an academic specialist centre fit the ASOCOG Z0011 criteria and that the patient populations may not be comparable. The aim of our study was to assess the applicability of the Z0011 study to our patient population of a large District General Hospital in the UK and to what extent it should influence our practice. Methods: The Z0011 eligibility criteria for inclusion in analysis were applied to all patients undergoing SLNB for invasive cancer at West Hertfordshire Breast Unit from 2007–2011. These were: no neo-adjuvant chemotherapy, clinical T1 and T2 tumours, breast conserving surgery followed by whole breast radiotherapy and 1–3 positive nodes on SLNB. Patent characteristics and results were compared using fisher's exact test. Results: In our unit a total of 434 patients underwent SNLB of whom 64(14.7%) met the inclusion criteria of Z0011. Our patient population was comparable to that of Z0011 with regards to lymphovascular invasion, proportion of patients with micro-metastases and those with additional lymph nodes found on completion ALND. Our patients had significantly more T2 tumours. The only other statistically significant difference was in the proportion of estrogen receptor(ER) and progestrogen receptor (PR) positivity. Conclusion: Only a small proportion (14%) of patients undergoing SNLB in our patient population fit the criteria for Z0011. This was a higher proportion than in the previous UK study of this type. Similar to this study we found the proportion of patients with T2 tumours were greater in our patient population compared to Z0011. This is most likely a reflection of this unit not being a screening centre and brings in to question the international generalisability of Z0011. However the only other significant difference in our patients was a lower risk profile in terms of hormone rector positivity with more ER/PR positive and fewer ER/PR negative patients. The implications of Z0011, will in our practice, not make a significant difference to the rate of ANLD. We are however considering changing our patient management based on the result of Z0011 and this current study of our population, to offer no further axillary surgery to patients over 50 with T1 and ER/PR positive tumours who otherwise fit the Z0011 protocol. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-07-01.
Social Medicine in Eastern Europe: The Organization of Health Services and the Education of Medical Personnel in Czechoslovakia, Hungary, and Poland
Authors: Marshall F. Gilula
Journal: JAMA (1969)

Despite postwar depletion of health resources and manpower, Czechoslovakia, Hungary, and Poland have dramatically increased the level of health services offered to individual citizens. Dr. Weinerman and his wife-collaborator, Shirley, studied medical facilities in these countries during the spring of 1967. Their well-organized and clearly written analysis describes each country's health program in terms of its theoretical organization and goals as well as the actual delivery of health care. Although technical quality of more intricate health services falls below that found in many Western countries, Czechoslovakia, Hungary, and Poland have achieved sophistication of healthcare planning and organization that Western countries could well emulate. As an illuminating example of critical research, this book will interest health planners of any political persuasion. Three primary Eastern European health goals have been reduction of communicable disease, maternal and child health care, and environmental sanitation and hygiene. Standards and policy are set by national government,