tbuckley/cabot-search huggingface dataset:
Autoimmune Disease and Collagen Dermal Implants
Authors: Richard A. Beauchamp
Journal: Annals of Internal Medicine (1994)

Letters15 March 1994Autoimmune Disease and Collagen Dermal ImplantsRichard A. Beauchamp, MD, Jean Cukier, MD, and David E. Trentham, MDRichard A. Beauchamp, MDTexas Department of Health; Austin, TX 78756Search for more papers by this author, Jean Cukier, MDTexas Department of Health; Austin, TX 78756Search for more papers by this author, and David E. Trentham, MDTexas Department of Health; Austin, TX 78756Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-6-199403150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We vigorously disagree with Drs. Singh and Fries. Our study does not fully establish causality but is not biologically implausible. Bovine collagen injections produce delayed-type hypersensitivity reactions in 3% of patients and humoral immune responses in another 10% [1]. Immunization with type II collagen of bovine, human, chick, or rat origin induces autoimmune arthritis in rats [2], mice [3], and monkeys [4]. Other inducible autoimmune diseases include experimental allergic encephalomyelitis, thyroiditis, orchitis, and uveitis [5]. With only 322 patients participating in the 1985-86 survey by Lyon and colleagues, the probability of finding a patient with dermatomyositis or polymyositis ...References1. McCoy JP Jr, Schade WJ, Siegle RJ, Waldinger TP, Vanderveen EE, Swanson NA. Characterization of the humoral immune response to bovine collagen implants. Arch Dermatol. 1985; 121:990-4. Google Scholar2. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen: an experimental model of arthritis. J Exp Med. 1977; 146:857-68. Google Scholar3. Holmdahl R, Jansson L, Gullberg D, Rubin K, Forsberg PO, Klareskog L. Incidence of arthritis and autoreactivity of anti collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II. Clin Exp Immunol. 1985; 62:639-46. Google Scholar4. Cathcart ES, Hayes KC, Gonnerman WA, Lazzari AA, Franzblau C. Experimental arthritis in a nonhuman primate. I. Induction by bovine type II collagen. Lab Invest. 1986; 54:26-31. Google Scholar5. Samter M, Talmage DW, Frank MM, Austen KF, Claman HN, ed. Immunological Diseases. 4th ed. vol II. Boston: Little, Brown and Company; 1988:1437-916. Google Scholar Author, Article, and Disclosure InformationAuthors: Richard A. Beauchamp, MD; Jean Cukier, MD; David E. Trentham, MDAffiliations: Texas Department of Health; Austin, TX 78756 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1994Volume 120, Issue 6 Page: 524-526 Keywords Adverse reactions Autoimmune diseases Dermatomyositis Food and Drug Administration Humoral immune response Polymyositis Scleroderma Skin tests Thyroid Uveitis ePublished: 15 August 2000 Issue Published: 15 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Impact of war on infectious disease in Bosnia-Hercegovina
Authors: Z Puvacic, J Weinberg
Journal: BMJ (1994)

function of making the procedure more tolerable for patients.This may be partially explained by the amount of sedation given; we titrated the dose to produce light sedation to minimise the risks previously described.2Given the patients' opinion, we suggest that phenoperidine and droperidol should no longer be recommended and that light sedation with midazolam has few benefits.Our results suggest that routine sedation has little part to play in patients undergoing a single diagnostic procedure.We thank Mrs S Barrowclough and Miss K McConnely for their help with the bronchoscopies and completion of the visual analogue scales.
Validation of K-XRF bone lead measurement in young adults.
Authors: J A Hoppin, A C Aro, P L Williams, H Hu, P B Ryan
Journal: Environmental Health Perspectives (1995)

K-X-ray fluorescence (K-XRF) is a useful tool for assessing environmental exposure to lead in occupationally exposed individuals and older adults. This study explores the possibility of using this technique on young adults with low environmental lead exposure. Twenty-three college students, aged 18-21 years, were recruited for 2 hr of bone lead measurement. Bone lead measurements were taken from the mid-shaft tibia for periods of 30 or 60 min. In the analysis, 30-min measurements were combined so that each subject had the equivalent of two 60-min measurements. The average concentration of two bone lead measurements in this population ranged from -1.5 to 8.2 micrograms Pb/g bone mineral, with a mean of 3.0 micrograms Pb/g bone mineral. In a one sample t-test, this mean was significantly different from 0 (p < 0.0001). A linear trend with age was detected despite the small age range of our population. By doubling the sampling time, the reported measurement uncertainty decreased by a factor of 1.5, resulting in uncertainty estimates below the mean bone lead estimates. Power calculations using the observed variance estimates suggest that with 80% power, differences in bone lead concentration of 2-3 micrograms Pb/g bone mineral can be identified in groups of 100 or smaller. Due to the large within-person variation in young adults, K-XRF may not yet be a useful diagnostic tool for individual subjects, but it may be of great use to environmental scientists trying to characterize long-term lead exposure and dose in the general population or specific subpopulations.
Efficacy of a 1-week, twice-daily regimen of terbinafine 1 % cream in the treatment of interdigital tinea pedis
Authors: Brian Berman, Charles Ellis, James Leyden, Nicholas Lowe, Ronald Savin, Jerome Shupack, Matthew Stiller, Eduardo Tschen, Nardo Zaias, Jay E. Birnbaum
Journal: Journal of the American Academy of Dermatology (1992)
Patients' preferences for appointment times.
Authors: N Cartwright, C Johnson, S Jones
Journal: BMJ (1990)

Subjects, methods, and results We performed the study in a general practice in Ley land, Lancashire, that had seven partners and a list of 11 655 patients. Surgeries were held continuously from 8 am to 6 pm on Mondays to Fridays. All patients on the age-sex register of the practice who were over 18 and had their birthday in April were sent a question? naire that asked what time they would prefer to attend the surgery, both generally and for specific clinics; how often they had visited a doctor at the surgery in the past year; and whether inconvenient times of access had caused problems. Patients with children were asked what time they would prefer to have appointments for them, and whether this differed from their choice for their own appointment. Patients were also asked when they worked and whether they would like surgeries at weekends. We sent 949 questionnaires and 586 (62%) were returned completed. Four hundred and fifty three patients had a convenient time in mind when they made a routine appointment. Clinics before 9 am were preferred by 133 patients, from 9 to 11 am (the conventional time of morning clinics) by 192, from 3 to 6 pm by 147, and after 6 pm by only 29 (table). Appointments between 9 and 11 am were preferred by the largest proportion (44%) of parents with children aged under 5. Women with children aged under 5 were significantly more likely to want an appointment between 9 am and 11 am for their children than for themselves (p<0*0001, x test). One hundred and nine (57%) parents with children of school age pre? ferred appointments for them between 3 and 6 pm. Patterns of work influenced preferences: the 29 patients who preferred appointments after 6 pm all worked during the day, and the 20 who worked only in the afternoons preferred to attend during the morning. The table shows the appointment times preferred by people attending well woman clinics and for health checks. Three hundred and eighty one patients thought that the practice should offer appointments at weekends for routine problems; 312 on Saturday morning, 103 on Number (percentage) of patients preferring particular appointmnu times for themselves and their children at a general practice
Secrets of inflammation only partly revealed
Authors: Jaan Kangilaski
Journal: JAMA (1981)

The best way to deal with inflammation and resulting pain may be to control the migration of circulating monocytic leukocytes. The key, according to Derek A. Willoughby, DSc, FRCPath, is to<i>control</i>rather than stop such migration because modern research has by no means disproved the old maxim that "inflammation is a salutary process." Since inflammation is a side effect of the efforts of leukocytes to deal with antigenic injury or insult, blocking WBC activity could well be harmful in the long run. Willoughby, who is professor of experimental pathology and director of rheumatological research at St Bartholomew's Hospital, London, was one of the speakers at a symposium on "Cellular Aspects of Inflammation" that was held in conjunction with the American Rheumatism Association meeting in Boston. Other speakers at the symposium were K. Frank Austen, MD, Theodore B. Bayles Professor of Medicine at Harvard Medical School, Boston; Christian René de
Hematopoietic Stem Cell Transplantation
Authors: Paulette Mehta
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute effects of ozone on the pulmonary function of exercising schoolchildren from Mexico City.
Authors: M Castillejos, D R Gold, A I Damokosh, P Serrano, G Allen, W F McDonnell, D Dockery, S Ruiz Velasco, M Hernández, C Hayes
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The acute effects of ozone (O3) on the change in lung function before and after exercise was assessed in 22 boys and 18 girls from 7 1/2 to 11 yr of age tested up to eight times over a 1 1/2-yr period outdoors (under a tarpaulin) at a school in Mexico City. Ozone and particulates were monitored at an adjacent government station, in the school yard, and under the tarp. Subjects were selected to oversample children with chronic respiratory symptoms, although children with active asthma under regular medication or FEV1 < 80% predicted were excluded. Of the participants, 21 had chronic cough, chronic phlegm, or ever wheeze with colds or apart from colds. Children performed two cycles of treadmill exercise (15 min) and rest (15 min) for a total of 1 h of intermittent exercise. Most subjects attained the target minute ventilation of 35 L/min/m2. Subjects exercised alternately during low ozone hours (8:00-10:00 A.M.) and during peak O3 hours (12:00-2:00 P.M.), to assure a range of exposures. On 85% of exercise days, the maximum daily 1-h average for ambient O3 exceeded the Mexican guideline of 110 parts per billion (ppb). O3 exposure during the hour of exercise was divided into quintiles, and the response was adjusted for repeated measures, subject having a cold, and prior outdoor exercise. Ambient O3 in the fifth quintile (mean = 229 ppb) was associated with a percentage change in FVC (-1.43% +/- 0.70), FEV1 (-2.85% +/- 0.79), FEF25-75% (-6.32 +/- 1.87) and FEV1 (-1.41% +/- 0.46).(ABSTRACT TRUNCATED AT 250 WORDS)
Disseminated Histoplasmosis in Corticosteroid-Treated Patients
Authors: William E. Dismukes
Journal: JAMA (1978)

Although Histoplasma capsulatum is not generally considered an opportunistic organism, we have seen five corticosteroid-treated patients in whom disseminated histoplasmosis (DH) developed. Persistent, unexplained fever was the predominant symptom in each. Death was directly attributable to DH in four. The interval from onset of symptoms to diagnosis ranged from 11 to 75 days; delay in diagnosis adversely affected prognosis. Culture of the bone marrow appears to be the best diagnostic study. The pathologic features of DH in immunocompromised hosts are the presence of large numbers of Histoplasma yeast forms within macrophages, absence of discrete granulomas, and a reduced or absent inflammatory response. Histoplasma capsulatum should be considered as a possible cause in any immunosuppressed patient with unexplained fever, especially if the patient has been receiving corticosteroid therapy.
Obstetric anaesthetic and analgesic services in Wales.
Authors: B Hibbard, G Rees, M Rosen
Journal: BMJ (1979)

A survey of obstetric anaesthetic services in Wales covering 21 major units in which over 31 000 deliveries take place annually showed inadequacies in staffing at consultant and resident anaesthetist level. At least 20 additional consultant sessions were required to meet the recommendations of the Association of Anaesthetists of Great Britain and Ireland. If patients' requests for epidural analgesia are to be met some reorganisation and centralisation of facilities is needed.
Additional Dose Urged for Some Receiving Haemophilus influenzae Vaccine in Early '90s
Authors: Charles Marwick
Journal: JAMA (1992)

PHYSICIANS are being advised that infants and children immunized with the<i>Haemophilus influenzae</i>type b conjugate vaccine PedvaxHIB<sup>©</sup>(Meningococcal Protein Conjugate) between December 1990—when the vaccine was licensed—and March 1992 should be given an additional dose. The first 16 lots of PedvaxHIB distributed to physicians may have lower than expected immunogenicity, the manufacturer says. Lots producing lower than expected immunogenicity are characterized by certain biochemical markers, and all of them have been identified, says Paul M. Mendelman, MD, clinical research director, Merck Sharp &amp; Dohme research laboratories, West Point, Pa. The issue now is those who have received vaccine from these lots, says Merck's Wayne Morges, PhD. It is impossible to define the future risk to any of these children, he says, so "our recommendation is that those who received vaccine from these lots should be given one additional dose in order to be assured of continuing protection." <h3>Letter</h3>
Abstract 2368: Autotaxin/Enpp2 controls of bone metastasis formation through osteoclast function
Authors: Marion David, Estelle Wannecq, Sylvia Jansen, Blandine Deux, Johnny Ribeiro, Claire-Marie Serre, Sandra Grès, Nathalie Bendriss-Vermare, Mathieu Bollen, Jean-Sébastien Saulnier-Blache, Philippe Clézardin, Olivier Peyruchaud
Journal: Cancer Research (2010)

Abstract Autotaxin (ATX, NPP-2) is a secreted protein with both an oncogenic action on mouse breast tissue and metastatic properties on breast cancer cells. Due to its lysophospholipase D activity, ATX generates lysophosphatidic acid (LPA) from lysophosphatidylcholine and controls LPA levels in the blood. We have recently showed that platelet-derived LPA promotes the progression of osteolytic bone metastases of breast cancer cells. However, how LPA is produced at the metastatic site and the role of ATX by cancer cells in this metastasis process are still unknown. Here, we found that in vitro, forced expression of ATX in human breast cancer MDA-B02 cells (MDA-B02/ATX) increased invasiness, proliferation and enhanced their pro-osteoclastic function. In vivo, intravenous injection of MDA-B02/ATX cells to inmmunodeficiency BALB/C nude mice enhanced osteolytic bone metastasis formation, as judged by increased bone loss and tumor burden, and higher active osteoclast number at the bone metastatic site. Mouse 4T1 breast cancer cells induced the formation of osteolytic bone metastases after intracardiac injection in immunocompetent BALB/C mice. We found that 4T1 cells expressed active ATX. In vitro, silencing ATX[O1] expression inhibited invasion but not proliferation of 4T1-siATX cells. In vivo, silencing ATX expression inhibited the extent of osteolytic bone lesions and decreased the number of active osteoclasts at bone the metastatic site. Altogether, these results demonstrated that expression of ATX by cancer cells controls bone metastasis formation and that targeting ATX in patients might contribute to the development of additional therapies against bone metastases. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2368.
Dapsone in rheumatoid arthritis.
Authors: C Kelly, I D Griffiths
Journal: Annals of the Rheumatic Diseases (1981)

Dapsone in rheumatoid arthritisSir, We read with interest the paper by Swinson et al.1 on a double-blind trial of dapsone against placebo in the treatment of rheumatoid arthritis.We recently undertook a similar double-blind study using dapsone in an identical dose regimen to that already described (50 mg daily for one week and thereafter 100 mg daily) in 14 white patients with seropositive rheumatoid arthritis and comparing it against placebo (vitamin C) in 14 matched controls.While we observed a similar trend towards improvement in both clinical and serological parameters in the dapsone-treated group, the incidence of anaemia secondary to haemolysis in our dapsone-treated patients was greater than that previously recorded.2Four of the 14 patients receiving dapsone had falls in haemoglobin of greater than 3 g/dl, and a further 3 patients had falls of between 1 and 3 g/dl.In all cases the fall in haemoglobin occurred within 6 weeks of commencing the therapy.Only one patient in the placebo group had a fall in haemoglobin of greater than 1 g/dl.It has been demonstrated that the haemolytic activity of dapsone is dependent upon its being metabolised to an acetylated form.3Therefore, in an attempt to elucidate further why some of our patients should develop severe haemolysis, we assessed the acetylator status (using isoniazid) in 13 of the patients receiving dapsone, 3 of whom had had falls in haemoglobin of greater than 3 g/dl and 3 of whom had had falls between 1 and 3 g/dl.The acetylator studies were performed in the University Department of Pharmacology, Newcastle upon Tyne.Eight of the patients were fast acetylators, but we failed to observe any association between the acetylator status and the severity of haemolysis.This pilot study, therefore, while supporting the view that dapsone is an effective therapy in rheumatoid arthritis, also reveals a higher incidence of significant haemolysis than has previously been described.It does not appear that the identification of the acetylator status of rheumatoid patients is of any benefit in identifying patients who may develop significant haemolysis.
US calls for research into research integrity
Authors: R. Smith
Journal: BMJ (2000)

An effort is needed to conduct research into research integrity, said Chris Pascal, director of the US Office of Research Integrity, at the world's first conference on research integrity held in Washington last week.

We now have agreement, said Mr Pascal, that research integrity is important, but we need evidence to understand the reality. Dr Constance Atwell of the US National Institutes of Health (NIH) agreed, and the NIH is making money available to fund the research. The ultimate aim of such research, she …
Fatty liver index, gamma-glutamyltransferase, and early carotid plaques
Authors: Michaela Kozakova, Carlo Palombo, Marco Paterni Eng, Jacqueline Dekker, Allan Flyvbjerg, Asimina Mitrakou, Amalia Gastaldelli, Ele Ferrannini
Journal: Hepatology (2012)

An association between fatty liver and carotid atherosclerosis has been established; however, it is not clear whether this relationship is a consequence of shared conventional risk factors or whether it is determined by specific circulating factors originating from liver or adipose tissue. To identify the factors possibly linking fatty liver and atherosclerosis, we assessed, in 1,012 subjects free of confounding diseases (e.g., hypertension, diabetes, cardiovascular diseases, and dyslipidemia) and metabolic syndrome, the relationship between the presence of early plaques at carotid bifurcation and fatty liver index (FLI; a validated surrogate marker of fatty liver), as well as the associations between carotid plaque presence and established atherosclerotic risk factors, family history of cardiovascular disease (FH-CVD) or diabetes, insulin sensitivity, serum liver enzymes, adipokines, fatty free acids, and high-sensitivity C-reactive protein (hsCRP). A total of 55 of 1,012 subjects (5.4%) had small plaque at carotid bifurcation. Subjects with plaque were older and had higher prevalence of FLI ≥60 and FH-CVD, higher blood pressure, plasma low-density lipoprotein cholesterol, glucose, gamma-glutamyltransferase (GGT), and hsCRP, as compared to subjects without plaques (P < 0.05). In a logistic regression model, adjusted for sex, liver transaminase, and alcohol consumption, the independent predictors of plaque presence were age (P < 0.0005), FLI ≥60 (P < 0.0005), and current smoking (P < 0.05). When FLI in the model was replaced by variables used in its equation (e.g., body mass index, waist circumference, plasma triglycerides, and GGT), the independent determinants of plaque presence were age (P < 0.001), GGT (P = 0.001), and current smoking (P < 0.05).Our cross-sectional study suggests that subjects with FLI ≥60 are at higher risk of atherosclerotic lesions, independently of established risk factors, and that serum GGT may represent a link between fatty liver and the development of early atherosclerosis.