Retrobulbar Optic Neuritis Associated with Infliximab in a Patient with Crohn Disease
Authors: Betsy Y.C. Strong
Journal: Annals of Internal Medicine (2004)

Letters20 April 2004Retrobulbar Optic Neuritis Associated with Infliximab in a Patient with Crohn DiseaseBetsy Y.C. Strong, MD, Barbara C. Erny, MD, Howard Herzenberg, MD, and Kristen J. Razzeca, MDBetsy Y.C. Strong, MDFrom Camino Medical Group, Sunnyvale, CA 94086., Barbara C. Erny, MDFrom Camino Medical Group, Sunnyvale, CA 94086., Howard Herzenberg, MDFrom Camino Medical Group, Sunnyvale, CA 94086., and Kristen J. Razzeca, MDFrom Camino Medical Group, Sunnyvale, CA 94086.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-8-200404200-00037-w4 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Case Report: A 45-year-old woman with type 2 diabetes mellitus and Crohn disease developed retrobulbar optic neuritis that was temporally associated with infliximab treatment. Three years earlier, she had Bell palsy, which resolved. Two years earlier, she received a diagnosis of Crohn disease and nongranulomatous uveitis. She responded initially to prednisone and mesalamine, but her condition later worsened, and she developed an enterovaginal fistula. She responded well to azathioprine; intravenous antibiotics; intravenous corticosteroids; and infliximab, 5 mg/kg of body weight. She continued to take infliximab every other month, and corticosteroids were successfully withdrawn.A week after the ...References1. Wray SH. Optic neuritis.. In: Albert DM, Jakobiec FA, Azar DT, Gragoudas ES, Power SM, Robinson NL, eds. Principles and Practice of Ophthalmology. 2nd ed. Philadelphia: WB Saunders; 1999:4117-37. Google Scholar2. Rustgi A, et al . Gastrointestinal and nutritional disorders.. In: Albert DM, Jakobiec FA, Azar DT, Gragoudas ES, Power SM, Robinson NL, eds. Principles and Practice of Ophthalmology. 2nd ed. Philadelphia: WB Saunders; 1999:4653-64. Google Scholar3. Sedwick LA, Klingele TG, Burde RM, Behrens MM. 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