tbuckley/cabot-search huggingface dataset:
Asymptomatic Gallstones in Diabetic Persons
Authors: DAVID HOCH
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 December 1987Asymptomatic Gallstones in Diabetic PersonsDAVID HOCH, M.D., BETH SCHORR-LESNICK, M.D., PAUL MARANTZ, M.D., M.P.H.DAVID HOCH, M.D.Search for more papers by this author, BETH SCHORR-LESNICK, M.D.Search for more papers by this author, PAUL MARANTZ, M.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-6-942_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Ransohoff and colleagues (1) have provided an interesting reexamination of the clinical dogma that surgery should be considered for diabetic patients with asymptomatic gallstones. There is, however, a methodologic problem we feel should be addressed before this approach is abandoned.To arrive at the final sample of 311 patients, 1978 charts were reviewed. Among the exclusion criteria was acute pancreatitis, accounting for 87 patients. No rationale was given for this exclusion, and if there is a relation between development of pancreatitis and diabetes, this could lead to significant confounding.The importance of this factor can be examined...Reference1. RANSOHOFFMILLERFORSYTHEHERMANN DGSR. Outcome of acute cholecystitis in patients with diabetes mellitus. Ann Intern Med. 1987;106:829-32. LinkGoogle Scholar1. RANSOHOFFMILLERFORSYTHEHERMAN DGSR. Outcome of acute cholecystitis in patients with diabetes mellitus. Ann Intern Med. 1987;106:829-32. LinkGoogle Scholar2. TANWARREN EK. Diseases of the gallbladder and bile ducts. In: SCHIFF L, SCHIFF ER, eds. Diseases of the Liver. Philadelphia: J.B. Lippincott Company; 1982:1507-59. Google Scholar3. SOLOWAY R. Asymptomatic gallstones. In: WYNGAARDEN JB, SMITH LH JR. Cecil Textbook of Medicine. 17th ed. Philadelphia: W.B. Saunders Company; 1985:855. Google Scholar4. FROMMBAZZOLI HF. Medical dissolution of cholesterol gallstones. In: COHEN S, SOLOWAY RD, eds. Gallstones. New York: Churchill Livingstone: 1985:167-78. Google Scholar5. SOERGEL K. Acute pancreatitis. In: SLEISENGER MH, FORDTRAN JS, eds. Gastrointestinal Disease. Philadelphia: W.B. Saunders Company, 1983:1462-85. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montefiore Medical Center Bronx, NY 10467 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1987Volume 107, Issue 6Page: 942-942KeywordsAcute pancreatitisChartsPancreatitisSurgery Issue Published: 1 December 1987 PDF DownloadLoading ...
532 IMPACT OF INVASIVE ASPERGILLOSIS ON SHORT-TERM MORTALITY IN PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS
Authors: T. Gustot, E. Maillart, M. Bocci, R. Surin, J. Schreiber, V. Lucidi, D. Degré, V. Donckier, F. Jacobs, C. Moreno
Journal: Journal of Hepatology (2013)
Lung cancer associated with hypercalcemia induced by concurrently elevated parathyroid hormone and parathyroid hormone-related protein levels
Authors: Keiko Uchimura, Takehiko Mokuno, Akio Nagasaka, Nobuki Hayakawa, Taiya Kato, Naho Yamazaki, Takako Kobayashi, Mutsuko Nagata, Motoko Kotake, Mitsuyasu Itoh, Toru Tsujimura, Katsumi Iwase
Journal: Metabolism (2002)
The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio
Authors: E Terpos, D Mihou, R Szydlo, K Tsimirika, C Karkantaris, M Politou, E Voskaridou, A Rahemtulla, M A Dimopoulos, K Zervas
Journal: Leukemia (2005)
SOME FUNDAMENTALS OF POSTGRADUATE EDUCATION FOR THE PHYSICIAN
Authors: G. N. Aagaard
Journal: JAMA (1952)

The purpose of postgraduate, or continuation, education is to keep the practicing general physician or specialist up-to-date. Its aim should be to stimulate the physician to such an extent that he continues to be a student of medicine throughout his professional life. Postgraduate education should not be confused with graduate education or residency training, through which a physician is trained to become a specialist in a given field of medical practice. The rapid progress in all branches of medical science makes it essential that both general physicians and specialists constantly strive to keep informed about new medical knowledge and techniques. When one considers how quickly a physician's knowledge becomes outdated, one is impressed with the importance of this phase of medical education. It is encouraging, and yet frightening, to realize the amount of new information and the many changing ideas that can be brought forward in such a short period
The placenta: transcriptional, epigenetic, and physiological integration during development
Authors: Emin Maltepe, Anna I. Bakardjiev, Susan J. Fisher
Journal: Journal of Clinical Investigation (2010)

The placenta provides critical transport functions between the maternal and fetal circulations during intrauterine development. Formation of this interface relies on coordinated interactions among transcriptional, epigenetic, and environmental factors. Here we describe these mechanisms in the context of the differentiation of placental cells (trophoblasts) and synthesize current knowledge about how they interact to generate a functional placenta. Developing an understanding of these pathways contributes to an improvement of our models for studying trophoblast biology and sheds light on the etiology of pregnancy complications and the in utero programming of adult diseases.
Abstract 3158: Identifying novel genes critical to invasion in head and neck squamous cell carcinoma
Authors: Sangeeta K. Jayakar, Olivier D. Loudig, Margaret Brandwein-Gensler, Ryung S. Kim, Michael B. Prystowsky, Jeffrey E. Segall, Thomas J. Belbin
Journal: Cancer Research (2014)

Abstract Oral squamous cell carcinomas (OSCC) have a poor patient prognosis, which is attributed to their invasive nature. Our goal was to identify specific genes that are important in OSCC invasion utilizing genome-wide expression data generated from HNSCC patient tumor samples of varying degrees of invasiveness. Invasion was assessed using the histological parameter pattern of invasion (POI), which describes the manner in which tumor cells infiltrate the normal tissue at the tumor-host interface. POI was used to categorize tumor resections into five types (1-5), type 5 being the most invasive with a “widely dispersed pattern of tumor infiltrate” and correlated significantly with the appearance of local recurrence and decreased overall survival of the patients after surgery. Global gene expression data was acquired from analysis of the surgical resections from 9 OSCC patient samples collected at Montefiore Medical Center between 2001 and 2008. Tumor cell-enriched cores from FFPE samples were used to generate global gene expression data using the Illumina® WG-DASL array to compare gene expression in four tumors that were WPOI type 5 and five tumors that were WPOI type 3. RNA extracted from flash-frozen tumor samples following surgical resection from the same patients was used to obtain global gene expression data using the Illumina® HumanHT-12 v4 Expression BeadChip. Candidate genes were assessed using in vitro invasion assays following siRNA knockdown of specific gene expression using siGENOME smart pools from Dharmacon. When both gene expression datasets were analyzed, we identified 104 genes that were overexpressed at least 1.5-fold in the WPOI type 5 tumors compared to the less invasive WPOI type 3 tumors. Fifty genes were initially tested based on functional criteria. In our initial screen, 16 of these genes showed a significant reduction in tumor cell invasion when expression was knocked down by siRNA in an OSCC cell line. The top gene from the screen, APOE, is now being further examined to determine a mechanistic explanation for its effect on invasion. Downstream signaling of APOE receptors and how this may interact with invasion are currently being assessed. This initial screen of global gene expression data in combination with pattern of invasion has revealed APOE as a novel gene that may play a critical role in OSCC invasion. Citation Format: Sangeeta K. Jayakar, Olivier D. Loudig, Margaret Brandwein-Gensler, Ryung S. Kim, Michael B. Prystowsky, Jeffrey E. Segall, Thomas J. Belbin. Identifying novel genes critical to invasion in head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3158. doi:10.1158/1538-7445.AM2014-3158
Gender is an independent predictor of both in-hospital and one-year outcomes following primary intervention for acute myocardial infarction
Authors: Kimberly A. Skelding, Kishore Harjai, Laxmi Mehta, Gregg W. Stone, David A. Cox, Judith A. Boura, Lorelei L. Grines, William W. O'Neill, Cindy L. Grines
Journal: Journal of the American College of Cardiology (2002)
Regional Heparinization during Haemodialysis
Authors: R. Patel
Journal: BMJ (1967)

MEDICAJOSerum and urine levels of cephaloridine were measured during 20 treatments in the higher dosage schedule.The mean serum level was 36 pg./ml. (range 8-64 Mug./ml.) and the mean urine level 2,129 pg./ml. (range
THE PRESENT STATUS OF BRAIN SURGERY.
Authors: M. ALLEN STARR
Journal: JAMA (1906)

It is twenty years since the first operations on the brain for the relief of tumors, epilepsy, and abscess were undertaken, and the data for final conclusions in regard to the propriety of such operations in various conditions are now available.  The enthusiasm with which these operations were performed at the outset has subsided and it is now possible to take a broader and calmer view of the entire subject; to realize the limitations of such operations; to appreciate their true value and to determine with considerable exactness the class of cases in which brain surgery promises success.  In this review I shall endeavor to present conclusions derived from an extensive experience in this field, and when statistics are cited too great stress will not be laid on them, as I realize that very many cases, both of a favorable and unfavorable kind, have not been published. I shall take
Bloodletting and Miraculous Cures
Authors: Helen Roberts
Journal: BMJ (2006)

I met a clever young doctor at a party recently who had read for a philosophy degree after graduating in medicine. “A degree in medicine is like doing 27 GCSEs,” she explained—further intellectual challenge was needed. 

This month, the most prestigious literary award in Canada, the Giller Prize, previously won by Alice Munro and Margaret Atwood, went to a young accident and emergency physician, Vincent Lam, for a book of linked short stories. He is reported as saying that …
The impact of SF3B1 mutations in CLL on the DNA-damage response
Authors: G D te Raa, I A M Derks, V Navrkalova, A Skowronska, P D Moerland, J van Laar, C Oldreive, H Monsuur, M Trbusek, J Malcikova, M Lodén, C H Geisler, J Hüllein, A Jethwa, T Zenz, S Pospisilova, T Stankovic, M H J van Oers, A P Kater, E Eldering
Journal: Leukemia (2014)
MUSCLE BUILDING AS ILLUSTRATED BY THE MODERN SAMSON, SANDOW.
Authors: G. FRANK LYDSTON
Journal: JAMA (1893)

It has frequently been remarked that men of the present day are not so strong as those of times past, and there are many reasons for this assertion. An inspection of ancient armor is sufficient to convince one of the truth of this statement. In looking at specimens of ancient armor, we are at once impressed with their great weight and comparatively small size. It would distress John L. Sullivan, I have no doubt, to force himself into one of the largest suits of armor that have thus far been exhibited. Once he had succeeded in arraying himself in the suit, he would doubtless feel more like reposing peacefully upon the ground than vaulting into a saddle and running a tilt in a tourney. One thing is certain, viz: that the soldier of ancient times although by no means a Sullivan in physique, could put the average modern athlete to
Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial.
Authors: J Arendt, M Aldhous, V Marks
Journal: BMJ (1986)

Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial Jet lag is an ill defined phenomenon resulting from rapid flight across several time zones.'It is considered to be due to desynchronisation of circadian rhythms, such as the sleep-wake cycle, with local time and to lack of sleep.' A means of rapidly resynchronising body rhythms to local time would benefit people who suffer badly from jet lag.Various remedies for alleviating jet lag have been proposed: manipulation of dietary intake and, more recently, appropriate exposure to'bright light have been used, though both are time consuming.2 3We previously suggested that melatonin, a methoxyindole secreted by the pineal gland, might be simpler and more effective in treating jet lag.4In view of its resynchronising properties in animals,5 its ability to transduce light-dark information, its hypnotic effects in man, and its low toxicity we examined whether it helped people adapt to new time zones.
The plague’s the thing
Authors: Theodore Dalrymple
Journal: BMJ (2008)

Of all the epidemic diseases, plague is by far the most literary—or perhaps I should say has inspired the most literature, from Boccaccio to Camus. The inspiration of literature was not the only beneficial effect of the disease, however: the Plague Orders of Elizabethan England forbade Sunday indulgence in tippling, gaming, and tobacco taking but, most important of all, prohibited “the outrageous play at the football.” Who, observing any modern English football crowd, could deny that this would be a most excellent thing?

Some scholars maintain that the plague reduced Shakespeare’s output and shortened his career. Elizabethan playwrights were like journalists: they wrote only when there was an …
Modular Poly(ethylene glycol) Matrices for the Controlled 3D‐Localized Osteogenic Differentiation of Mesenchymal Stem Cells
Authors: Stéphanie Metzger, Philipp S. Lienemann, Chafik Ghayor, Wilfried Weber, Ivan Martin, Franz E. Weber, Martin Ehrbar
Journal: Advanced Healthcare Materials (2014)

The in vitro formation of physiologically relevant engineered tissues is still limited by the availability of adequate growth‐factor‐presenting cell‐instructive biomaterials, allowing simultaneous and three‐dimensionally localized differentiation of multiple tissue progenitor cells. Together with ever improving technologies such as microfluidics, printing, or lithography, these biomaterials could provide the basis for generating provisional cellular constructs, which can differentiate to form tissue mimetics. Although state‐of‐the‐art biomaterials are endowed with sophisticated modules for time‐ and space‐controlled positioning and release of bioactive molecules, reports on 3D arrangements of differentiation‐inducing growth factors are scarce. This paper describes the stable and localized immobilization of biotinylated bioactive molecules to a modular, Factor XIII‐cross‐linked poly(ethylene glycol) hydrogel platform using a genetically engineered streptavidin linker. Linker incorporation is demonstrated by Western blot, and streptavidin functionality is confirmed by capturing biotinylated alkaline phosphatase (ALP). After optimizing bone morphogenetic protein 2 (BMP‐2) biotinylation, streptavidin‐modified hydrogels are able to bind and present bioactive BMP‐2‐biotin. Finally, with this immobilization scheme for BMP‐2, the specific osteogenic differentiation of mesenchymal stem cells is demonstrated by inducing ALP expression in confined 3D areas. In future, this platform together with other affinity‐based strategies will be useful for the local incorporation of various growth factors for engineering cell‐responsive constructs.
Opportunities for non-fundholders
Authors: R Chapman
Journal: BMJ (1994)

Nearly 25 000 general practitioners currently remain nonfundholders1 (Scottish Office and Northern Ireland Office, personal communication). They include those who find the prospect of fundholding unacceptable, impractical, or irrelevant but who remain committed to securing the highest quality care possible for their patients.2 Both the General Medical Services Committee3 and the Royal College of General Practitioners4 have encouraged general practitioners to use the internal market to the benefit of their patients, and participation on commissioning or advisory groups has provided opportunities for translating these ambitions into action.

The Nottingham Non-Fundholders Group was formed to make the best use of the opportunities provided by the purchaser-provider system to benefit patients; on p 930 members describe its formation and early achievements.5 It is not alone; the recently formed National Association of Commissioning General Practitioners identified 42 groups after a single letter to the BMJ.6 Those expressing …
Futility and rationing in liver retransplantation: When and how can we say no?
Authors: Scott W. Biggins
Journal: Journal of Hepatology (2012)

Donor livers are a scarce, life-saving resource. For patients whose lives depend upon liver transplantation, the policies defining priority for donor livers are of ultimate importance. Fair and just utilization of available livers requires that policy makers understand how to balance the needs and interests of each of the stakeholders. Although significant medical and surgical advances have been made in the last three decades, many patients who undergo liver transplantation will eventually have early complications or recurrent liver disease resulting in failure of their transplanted liver graft.
STATE SUPERVISION OF MARRIAGE.
Authors: W. H. HEATH
Journal: JAMA (1902)

No time need be occupied before this audience in demonstrating that marriage is the foundation and keystone of family and state integrity, or that it is the most fundamental institution of society. Nor that the family is the natural and historic basis of it, being the origin of order, law, morality, education and justice. Neither need time be taken to show that indiscriminate union is associated with the gravest consequences, the influence of which, either directly or indirectly, is associated with the most gigantic evils, in fact with almost every offense against society and the state. It loosens the family ties, tends to immorality, and diminishes mutual and parental responsibility. From data in the premises, exact knowledge, we are in a position now to assign to heredity its proper importance, and to coincidentally formulate some plan or procedure having for its object such practical supervision of the whole question as
Adenoviral-mediated gene transfer to rabbit synovium in vivo.
Authors: B J Roessler, E D Allen, J M Wilson, J W Hartman, B L Davidson
Journal: Journal of Clinical Investigation (1993)

Currently, treatment for rheumatoid arthritis and other inflammatory arthropathies is often ineffective in ameliorating the progression of the disease, particularly the invasive destruction of cartilage and bone by rheumatoid synovium. Multiple aspects of this inflammatory process are mediated by the synovial lining cells (synoviocytes). Genetic modification of these cells in vivo represents a potential method for the treatment of these conditions. In this report, we describe a novel technique for the genetic transduction of synovial lining cells in vivo using recombinant adenoviral vectors and intraarticular injection techniques. Purified high titer suspensions of a recombinant adenoviral vector containing the gene for Escherichia coli beta-galactosidase (AdCMVlacZ) were directly injected into the hind knees of New Zealand white rabbits. Synovial tissues were then examined for transgenic lacZ expression using a combination of in situ staining for beta-galactosidase activity, immunohistochemical staining, and transmission electron microscopy. High efficiency gene transfer and lacZ expression was observed in both type A and type B synoviocytes throughout the articular and periarticular synovium of the rabbit knee, with continued expression of transgenic lacZ detected for > or = 8 wk after infection.
Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy.
Authors: P H Vachon, H Xu, L Liu, F Loechel, Y Hayashi, K Arahata, J C Reed, U M Wewer, E Engvall
Journal: Journal of Clinical Investigation (1997)

Mutations in genes coding for dystrophin, for alpha, beta, gamma, and delta-sarcoglycans, or for the alpha2 chain of the basement membrane component merosin (laminin-2/4) cause various forms of muscular dystrophy. Analyses of integrins showed an abnormal expression and localization of alpha7beta1 isoforms in myofibers of merosin-deficient human patients and mice, but not in dystrophin-deficient or sarcoglycan-deficient humans and animals. It was shown previously that skeletal muscle fibers require merosin for survival and function (Vachon, P.H., F. Loechel, H. Xu, U.M. Wewer, and E. Engvall. 1996. J. Cell Biol. 134:1483-1497). Correction of merosin deficiency in vitro through cell transfection with the merosin alpha2 chain restored the normal localization of alpha7beta1D integrins as well as myotube survival. Overexpression of the apoptosis-suppressing molecule Bcl-2 also promoted the survival of merosin-deficient myotubes, but did not restore a normal expression of alpha7beta1D integrins. Blocking of beta1 integrins in normal myotubes induced apoptosis and severely reduced their survival. These findings (a) identify alpha7beta1D integrins as the de facto receptors for merosin in skeletal muscle; (b) indicate a merosin dependence for the accurate expression and membrane localization of alpha7beta1D integrins in myofibers; (c) provide a molecular basis for the critical role of merosin in myofiber survival; and (d) add new insights to the pathogenesis of neuromuscular disorders.