tbuckley/cabot-search huggingface dataset:
Thermal injury induces both necrosis and apoptosis in rat skin
Authors: K. Iwasaki, M. Izawa, M. Mihara
Journal: British Journal of Dermatology (1997)

Journal Article Thermal injury induces both necrosis and apoptosis in rat skin Get access K. Iwasaki, K. Iwasaki Department of Dermatology, Faculty of Medicine, Tottori University, 36‐1 Nishi‐machi, Yonago 683, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Izawa, M. Izawa Department of Biosignalling, School of Life Science, Tottori University, 86 Nishi‐machi, Yonago 683, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Mihara M. Mihara Department of Dermatology, Faculty of Medicine, Tottori University, 36‐1 Nishi‐machi, Yonago 683, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 4, 1 October 1997, Pages 647–648, https://doi.org/10.1111/j.1365-2133.1997.tb03805.x Published: 01 October 1997
A sick society?
Authors: Des Spence
Journal: BMJ (2011)

Of course, I am just another middle class commentator on the recent riots in London and other cities. In my defence, my father lives in Hackney, and I played football in London Fields as a kid. My nephews were schooled in Hackney. And as a child of a fallen middle class family, I know something of family break-up, benefits, free school dinners, and comprehensive schools. I have also worked in an inner city practice for 15 years. What caused the riots?

Few will accept that the rioters were motivated mainly by …
Eye Findings in the Diagnosis of Fabry's Disease
Authors: Stephen E. Bloomfield
Journal: JAMA (1978)

Two patients underwent renal transplantation for what was thought to be glomerulonephritis and chronic pyelonephritis. The diagnosis of Fabry's disease was made as an incidental finding during an ophthalmologic consultation for evaluation of blurred vision. These two cases illustrate the usefulness of an eye examination in the correct diagnosis in patients with the multisystem complaints of Fabry's disease. The correct diagnosis was extremely important in understanding the other manifestations of this disease in the affected patient and in the genetic counseling of the family. (<i>JAMA</i>240:647-649, 1978)
Regulation of Food Intake and the Obesities.
Authors: Jean Mayer
Journal: Annals of Internal Medicine (1964)

s1 April 1964Regulation of Food Intake and the Obesities.Jean Mayer, Ph.D.Jean Mayer, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-719_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs the mechanism of regulation of food intake becomes better known, our understanding of the many ways in which it is susceptible to errors also grows. This problem is attacked in our laboratory at the thermodynamic, neurological, metabolic, behavioral, and cognitive levels. In experimental animals no less than 15 types of obesity have been studied; they can be classified from the etiologic viewpoint (genetic, traumatic, or environmental factors) or from the point of view of pathogenesis (regulatory obesities, where errors exist in the central mechanism regulating food intake; metabolic obesities, characterized by increased lipogenesis, decreased fat mobilization, oxidation, or both).... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Jean Mayer, Ph.D.Affiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 719-719KeywordsEatingFatsGeneticsLipogenesisObesityPathogenesisResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
Population based survival rates for childhood cancer in Britain, 1980-91
Authors: C A Stiller
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objectives</b>: To investigate the survival of children with cancer diagnosed during 1980-91 in order to assess the impact of developments in medical care on a population basis. <b>Design</b>: Retrospective cohort study. <b>Setting</b>: Great Britain. Subjects—14 973 children with cancer diagnosed during 1980-91 and included in the population based National Registry of Childhood Tumours. <b>Main outcome measures</b>: Actuarial survival rates. <b>Results</b>: For all cancers combined, two year survival increased from 66% to 76% between 1980-2 and 1989-91, and five year survival increased from 57% to 65% between 1980-2 and 1986-8. Significant increases in survival rates occurred among children with acute lymphoblastic leukaemia, acute nonlymphocytic leukaemia, retinoblastoma, osteosarcoma, Ewing9s sarcoma, rhabdomyosarcoma, and malignant gonadal germ cell tumours. No trend in survival was seen for children with Hodgkin9s disease, central nervous system tumours, neuroblastoma, or Wilms9s tumour. <b>Conclusions</b>: Nearly two thirds of children who have cancer diagnosed can now expect to survive at least 10 years.
Busulfan‐induced sideroblastic anemia
Authors: Louis A. Fernandez, Ekram Zayed
Journal: American Journal of Hematology (1988)

Abstract Patients in the stable phase of chronic myelogenous leukemia (CML) are usually treated with busulfan. The bone marrow of patients with CML may be exquisitely sensitive to busulfan, and occasionally such patients develop pancytopenia, secondary to hypoplasia or aplasia of the bone marrow, which is presumed to be due to busulfan‐induced marrow toxicity. We report a case of Philadelphia chromosome‐positive CML who developed pancytopenia while being treated with busulfan; however, the patient's bone marrow was not hypoplastic or aplastic but rather hyperplastic with sideroblastic changes. Busulfan is not known to cause sideroblastic changes, so this was considered to herald a transformation into acute leukemia. Busulfan was stopped, and only supportive treatment was given. To our surprise approximately 22 weeks after busulfan was stopped, the sideroblastic changes had disappeared and the bone marrow again showed features of CML. This case suggests that busulfan may cause sideroblastic anemia.
Sodium ferric gluconate complex in hemodialysis patients: Adverse reactions compared to placebo and iron dextran
Authors: Beckie Michael, Daniel W. Coyne, Steven Fishbane, Vaughn Folkert, Robert Lynn, Allen R. Nissenson, Rajiv Agarwal, Joseph W. Eschbach, Stephen Z. Fadem, J. Richard Trout, Jur Strobos, David G. Warnock, None Ferrlecit® Publication Committee
Journal: Kidney International (2002)
Mid Staffs and mortality data
Authors: F. Godlee
Journal: BMJ (2013)

Stafford Hospital in England’s West Midlands was just one of many medium sized hospitals treating a wide range of medical and surgical conditions within the NHS. But then, in 2007, the health analytics company Dr Foster reported higher than expected death rates among its patients. Few could have predicted the long and murky chain of events that would follow, culminating in a public inquiry chaired by Robert Francis (see our timeline at http://tw.gs/YxS0gV). The inquiry’s findings will be published next week.

This has been a bitter episode in the NHS’s history which, like the Bristol heart surgery scandal in 1998, is likely to echo down the years. Evidence given to the inquiry over …
A CASE OF TACHYCARDIA.
Authors: J. L. TRACY
Journal: JAMA (1898)

Mrs. —, aged 40, has many times during the last ten years told me about attacks of palpitation which she has had and which have come on suddenly, lasted from a few seconds to ten minutes and then as suddenly stopped. Many times I have been sent for when she had been having the attacks, but the heart would have quieted before I reached her. After an attack had passed off she would be weak and exhausted for a few hours, and then be in her usual health, which in appearance was a little below normal. I could never discover any organic trouble of the heart, nor of any other organ. Occasionally she would have attacks of urticaria, and 0.13 gram of quinia would produce intense redness all over her body. As often as every three months she had attacks of bronchial irritation, coughing almost incessantly for an hour at
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin–myosin interaction
Authors: H Yamashita
Journal: Cardiovascular Research (2003)

Objective: To investigate the functional role of myosin light chain (MLC) isoforms in cardiac muscles, we examined the motor function of two different myosins the structure of which differed only in the MLC. Methods: We purified myosin from atria (A-myosin) and ventricles (V-myosin) of young rats, which contained atrial-type and ventricular-type MLCs, respectively, but having identical α-heavy chain isoform. Actin filament velocity (Vel) was determined in the in vitro motility assay. Average force of myosin molecules (F) was estimated and single events of actin–myosin interaction were recorded with the laser trap technique. Results: Vel was slightly higher in A-myosin than in V-myosin, while actin-activated ATPase activity was not different. F, determined from force versus actin filament length relation, was ∼60% higher in V-myosin (3.3 vs. 2.1 pN/μm). The mean duration of isometric force events was longer in V-myosin than in A-myosin (323±13 vs. 294±30 ms, p<0.05), while the amplitudes of unitary displacement and force of a single myosin molecule did not differ between them. Conclusion: The MLC isoform can be a determinant of force-generating ability of cardiac myosin by modulating crossbridge kinetics without affecting the catalytic activity.
Effect of Age on Post-Heparin Lipase
Authors: Robert G. Brodows, Robert G. Campbell
Journal: New England Journal of Medicine (1972)

A HEPARIN-activated clearing factor, lipoprotein lipase, is considered to have an important role in facilitating the removal of triglycerides from the circulation. The activity of this enzyme is detectable in plasma by an in vitro assay and is commonly called postheparin lipolytic activity (PHLA).Aging has been associated with prolonged alimentary lipemia.1 2 There is also a positive correlation between fasting plasma triglyceride concentrations and age.3 , 4 To define further the effect of age on triglyceride removal, PHLA was measured in a group of elderly subjects.Methods and ResultsPHLA was measured by a modification of the method of Fredrickson, Ono and Davis . . .
Hepatotoxicity and Thioridazine Hydrochloride
Authors: Melvin J. Reinhart
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Dr. Sun begins his criticism of the article by Reinhart et al by suggesting a change from "suggestive" to "questionable." He concludes his letter by stating that "no evidence has been presented." The fact that these three cases were reported over a nine-month period in a unit which averages only 185 admissions in that period is more than we can write off to coincidence or viruses. Also, at the time of each increase in the SGPT and alkaline phosphatase, thioridazine was the only phenothiazine being ingested. In the second case, the thioridazine was not continued with the chlorpromazine as noted in Dr. Sun's letter. It was stated in the article that chlorpromazine was discontinued at the time thioridazine was initiated. While the patient was being maintained on a thioridazine regimen, the SGPT level dropped to within normal limits, 15 days following initiation of the treatment, and then
Pleurectomy for spontaneous pneumothorax in cystic fibrosis
Authors: P. F. Mitchell-Heggs, J. C. Batten
Journal: Thorax (1970)

Five cases of cystic fibrosis complicated by eight pneumothoraces are described. These cases come from a group of 49 patients who have attended the Brompton Hospital between 1964 and 1969 for management of their cystic fibrosis. Three of the patients, who had a total of six pneumothoraces, were managed by pleurectomy. Spontaneous pneumothoraces were a terminal event in a fourth patient, and an incidental finding which required no specific management in a fifth patient. The possible aetiology of the pneumothorax in cystic fibrosis is discussed with particular consideration of the known alveolar hypoplasia and overdistension and the abnormality of the visceral pleura. The results of pleurectomy in three patients are discussed both in relation to the successful avoidance of further pneumothoraces and in the notable absence of a restrictive ventilatory defect. In view of the relative success of pleurectomy we suggest that this treatment should be considered for any patient with cystic fibrosis who develops a spontaneous pneumothorax.
Eosinophilic Inflammation in Subjects with Mild-to-Moderate Asthma with and without Obesity: Disparity between Sputum and Biopsies
Authors: Erica van der Wiel, Nick H. T. ten Hacken, Maarten van den Berge, Wim Timens, Helen K. Reddel, Dirkje S. Postma
Journal: American Journal of Respiratory and Critical Care Medicine (2014)
Hematologic Malignancies With Extramedullary Spread of Disease
Authors: Nasir Shahab, Rowena L. Kissenger, Vikas Malhotra, Donald C. Doll
Journal: Journal of Clinical Oncology (2003)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.05.176 Journal of Clinical Oncology - published online before print November 1, 2016 PMID: 12721269 Hematologic Malignancies With Extramedullary Spread of Disease Case 2. Hepatosplenic T-Cell Lymphoma Nasir ShahabxNasir ShahabSearch for articles by this author , Rowena L. KissengerxRowena L. KissengerSearch for articles by this author , Vikas MalhotraxVikas MalhotraSearch for articles by this author , Donald C. DollxDonald C. DollSearch for articles by this author Show More University of Missouri-Columbia, Columbia, MO https://doi.org/10.1200/JCO.2003.05.176 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Whole blood targeting and activation of monocytes with TLR7 agonist formulated in cationic liposomes
Authors: Simon S Jensen, Pia T Johansen, Daniel Zucker, Jonas Henriksen, Thomas Andresen, Alcide Barberis, Roberto Maj, Houman Pourhassan, Jeanette Wern, Monika Gad
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Monocytes are one of the major phagocytic cells in the periphery that patrols the circulation for invading pathogens, and upon activation differentiates into dendritic cells, capable of migration to lymph nodes eliciting an adaptive immune response. Monocytes has for more than a
Focusing on the Body of Evidence—Reply
Authors: M. Hassan Murad, Victor M. Montori
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Population and Evolutionary Dynamics of Helitron Transposable Elements in Arabidopsis thaliana
Authors: J. D. Hollister, B. S. Gaut
Journal: Molecular Biology and Evolution (2007)

Helitrons, a recently discovered superfamily of DNA transposons that capture host gene fragments, constitute up to 2% of the Arabidopsis thaliana genome. In this study, we identified 565 insertions of a family of nonautonomous Helitrons, known as Basho elements. We aligned subsets of these elements, estimated their phylogenetic relationships, and used branch lengths to yield insight into the age of each Basho insertion. The age distribution suggests that 87% of Bashos inserted within 5 Myr, subsequent to the divergence between A. thaliana and its sister species Arabidopsis lyrata. We screened 278 of these insertions for their presence or absence in a sample of 47 A. thaliana accessions. With both phylogenetic and population frequency data, we investigated the effects of gene density, recombination rate, and element length on Basho persistence. Our analyses suggested that longer Basho copies are less likely to persist in the genome, consistent with selection against the deleterious effects of ectopic recombination between Basho elements. Furthermore, we determined that 39% of Basho elements contain fragments of expressed protein-coding genes, but all of these fragments were explained by only 5 gene-capture events. Overall, the picture of A. thaliana Helitron evolution is one of rapid expansion, relatively few gene-capture events, and weak selection correlated with element length.
Combined PET/CT by 18F-FDOPA, 18F-FDA, 18F-FDG, and MRI Correlation on a Patient With Carney Triad
Authors: Georgios Z. Papadakis, Nicholas J. Patronas, Clara C. Chen, J. Aidan Carney, Constantine A. Stratakis
Journal: Clinical Nuclear Medicine (2014)

Carney triad is a rare syndrome involving gastrointestinal stromal tumor, pulmonary chondroma, and extra-adrenal paraganglioma. We present a 21-year-old woman with the complete triad who was evaluated with MRI, F-FDOPA, F-FDA, and F-FDG. F-FDOPA best demonstrated the paraganglioma, whereas hepatic metastases noted by MRI demonstrated increased uptake only by F-FDG.
Angina of Micturition
Authors: JAMES J. MORRIS, HENRY D. MCINTOSH
Journal: Circulation (1963)

A case history of a 46-year-old Negro male was presented with rheumatic aortic insufficiency, angina pectoris, and possible subacute bacterial endocarditis. While hospitalized, the patient developed angina pectoris associated with micturition. This was not accompanied by a change in blood pressure, pulse, or increase in respiratory rate. The striking similarity to a description of a case approximately 300 years ago is pointed out and possible mechanisms of this association of angina and micturition are considered.
Randomized, Placebo-Controlled Trial of Lactobacillus rhamnosus GG as Treatment of Mild to Moderate Atopic Dermatitis in Infancy
Authors: C. Grüber, M. Wendt, S. Lau, M. Kulig, U. Wahn, T. Werfel, B. Niggemann
Journal: Journal of Allergy and Clinical Immunology (2006)
A3.27 Effect of rituximab on different isotypes of serum immunoglobulins in patients with SLE
Authors: Venkat Reddy, Lina Martinez, David Isenberg, Geraldine Cambridge, Maria Leandro
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Aims</h3> The impact of rituximab therapy on different compartments of the immune system may inform as to the possible clinical response and also maintenance of protective immunity. We conducted a retrospective study of serum IgM, IgG and IgA in 59 patients with SLE, following the first cycle of B cell depletion therapy based on rituximab (RTX). <h3>Materials and Methods</h3> Serum Ig levels (IgA, IgG and IgM) were assessed at baseline (before first infusion of RTX) and at 1, 2, 6, 9 and 12 months after the first cycle of RTX in 59 patients with SLE. Paired t-test and Spearman's rank correlation were used to analyse changes in serum Ig levels and to analyse correlations, respectively. <h3>Results</h3> Median baseline serum IgA level was 2.9g/L, which fell by a mean 10% and 8% (p&lt;0.05), at 1 and 2 months after RTX but were similar to baseline at 12 months. IgA levels at baseline showed a positive correlation with IgA levels at all time points (r<sup>2</sup>≥0.5, p&lt;0.0001 for all). Median baseline serum IgG level was 13.9g/L, which was significantly reduced (p&lt;0.05) (means of 10% and 20% at 1 and 2 months after RTX) but levels were similar to baseline at all other time-points. Median baseline serum IgM levels were 1.0g/L, which reduced by means of 20%, 31%, 28%, 55% and 40% at 1, 2, 6, 9, and 12 months respectively (p&lt;0.005 for all). Serum IgG levels at 12 months either reduced (group1) or increased (group2) from baseline. There was a significant difference in baseline IgG levels between the two groups with a median level of 17.24g/l and 10.7g/l (p = 0.0005) for group 1 and 2, respectively. Baseline IgG levels positively correlated with IgG levels at all time-points (r<sup>2</sup> ≥ 0.6, p&lt;0.005 for all). However, there was no difference in IgG levels at 12 months between the two groups. Whereas in patients with IgM levels &lt;0.4g/l at 12 months, there was a significant positive correlation only between baseline IgM levels and at 2 months, but not at other time-points. There was no correlation between absolute numbers of CD19+ cells at baseline and serum Ig levels or%change in Ig levels at any time-points. <h3>Conclusion</h3> Our results reveal a disparity in changes in IgA, IgG and IgM levels following rituximab treatment in SLE. Disease-associated defects in B cell biology particularly accessory cell and T-cell interactions associated with B cell survival and class-switch may, at least in part, account for this disparity.
Blalock-Taussig anastomosis in 126 patients with Fallot's tetralogy
Authors: J. M. Reid, E. N. Coleman, R. S. Barclay, J. G. Stevenson
Journal: Thorax (1973)

The long-term results of Blalock anastomosis in 126 patients (1954-71) for Fallot9s tetralogy are presented. The operative mortality was 10% and the overall mortality 38%. The 78 survivors were reviewed after periods of surveillance ranging from six months to 17 years. Complications were few. It is concluded that although total correction as a primary procedure has become the treatment of choice in most, it may in some instances never be technically feasible because of extreme underdevelopment of the right ventricular outflow tract. In the very young with urgent symptoms and rapid deterioration total correction would be considered hazardous. In the infant a high operative mortality reflected the inadequate calibre of the vessels used in the shunt operation.
Tubal Sterilization — Safe and Effective
Authors: Carolyn Westhoff
Journal: New England Journal of Medicine (2000)

Eleven million U.S. women rely on tubal sterilization to prevent pregnancy.1 Although the annual number of women undergoing sterilization (approximately 700,000) remains stable, the techniques, timing, and setting of the surgery have changed.2 In the early 1970s, the usual sterilization procedure was partial salpingectomy with the use of laparotomy, and it was usually performed after delivery. Subsequently, nonpuerperal sterilization with a laparoscopic approach became as common as the postpartum open procedures, and now nearly all nonpuerperal, or interval, sterilizations are performed as outpatient procedures.3 Only postpartum procedures are still performed in the hospital.The mortality rates associated with sterilization in . . .