Zollinger-Ellison Syndrome
Authors: A. RICHARD CHRISTLIEB
Journal: Annals of Internal Medicine (1964)

Case Studies1 June 1964Zollinger-Ellison SyndromeReport of a Case Supporting the Hypothesis of Extrapancreatic EtiologyA. RICHARD CHRISTLIEB, M.D., MICHAEL SHENDE, M.D., MARVIN M. SCHUSTER, M.D.A. RICHARD CHRISTLIEB, M.D.Search for more papers by this author, MICHAEL SHENDE, M.D.Search for more papers by this author, MARVIN M. SCHUSTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-6-1059 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA case of the Zollinger-Ellison syndrome is reported in which unusual findings support the theory that the pathological features seen in this syndrome may be the result of an undetermined stimulus of extrapancreatic origin acting on islet tissue.CASE REPORTC. P., a 35-year-old single Negro male piano player, was admitted to the Baltimore City Hospitals in July, 1961, because of three episodes of vomiting blood-streaked material on the day of admission.Family history and past history were not contributory to the present illness. He gave a history of drinking 1 pint to 1 quart of whiskey daily for 15...References1. ZOLLINGERELLISON RMEH: Primary peptic ulcerations of the jejunum with islet cell tumors of the pancreas. Ann. Surg. 142: 709, 1955. CrossrefMedlineGoogle Scholar2. BLOODWORTHELLIOT JMDW: The histochemistry of pancreatic islet cell lesions. JAMA 183: 1011, 1963. CrossrefMedlineGoogle Scholar3. MORRISONRAWSONFITTS ABAJWT: The syndrome of refractory watery diarrhea and hypokalemia in patients with a non-insulin secreting islet cell tumor. Amer. J. Med. 32: 119, 1962. CrossrefMedlineGoogle Scholar4. SHAYCHEYKOIDEBURNETT HWYSMWE: Mechanism of the disordered physiology involved in the Zollinger-Ellison Syndrome. Amer. J. Dig. Dis. 7: 401, 1962. CrossrefMedlineGoogle Scholar5. ZOLLINGERMCPHERSON RMRC: Ulcerogenic tumors of the pancreas. Amer. J. Surg. 95: 359, 1958. CrossrefMedlineGoogle Scholar6. SUMMERSKILL WH: Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet cell hyperplasia. Lancet 1: 120, 1959. CrossrefMedlineGoogle Scholar7. OBERHELMANNELSONDRAGSTEDT HATSLR: Peptic ulcer associated with tumors of the pancreas. Arch. Surg. (Chicago) 77: 402, 1958. CrossrefGoogle Scholar8. EISEMANMAYNARD BRM: A non insulin producing islet cell adenoma associated with progressive peptic ulceration. Gastroenterology 31: 296, 1956. CrossrefMedlineGoogle Scholar9. ELLISON EH: The ulcerogenic tumor of the pancreas. Surgery 40: 147, 1956. MedlineGoogle Scholar10. SAILERZINNINGER SMM: Massive islet cell tumor of the pancreas without hypoglycemia. Surg. Gynec. Obstet. 82: 301, 1946. MedlineGoogle Scholar11. MIEHERHARTSOCKGOOKASBALLARDFRAME WCRJMCHSB: Peptic ulcer as a manifestation of familial polyendocrine disease. JAMA 179: 114, 1962. CrossrefGoogle Scholar12. CODEHALLENBECKSUMMERSKILL EFGAWH: Extraction of a gastric secretogogue from primary and metastatic islet cell tumors in two cases of the Zollinger-Ellison syndrome. J. Surg. Res. 2: 136, 1962. CrossrefMedlineGoogle Scholar13. GREGORYTRACYFRENCHSIRCUS RAHJJMW: Extraction of a gastrin-like substance from a pancreatic tumor in a case of the Zollinger-Ellison syndrome. Lancet 1: 1045, 1960. CrossrefMedlineGoogle Scholar14. OSBORNEBROWNLECOMPTE MPMEPM: Ulcerogenic non-beta-cell islet cell carcinoma. Amer. J. Surg. 100: 48, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, MarylandFrom the Departments of Medicine and Pathology, Baltimore City Hospitals and the Johns Hopkins University School of Medicine.Requests for reprints should be addressed to Marvin M. Schuster, M.D., Assistant Chief of Medicine, The Baltimore City Hospitals, 4940 Eastern Avenue, Baltimore 24, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1964Volume 60, Issue 6Page: 1059-1065KeywordsAdenomasHospital medicinePancreasVomitingZollinger Ellison syndrome Issue Published: 1 June 1964 PDF downloadLoading ...