Hepatitis Associated with Ranitidine
Authors: MARCOS A. SOUZA LIMA
Journal: Annals of Internal Medicine (1984)

Brief Reports1 August 1984Hepatitis Associated with RanitidineMARCOS A. SOUZA LIMA, M.D.MARCOS A. SOUZA LIMA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-2-207 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRanitidine (Zantac; Glaxo, Incorporated, Research Triangle Park, North Carolina) is a relatively new H2-receptor antagonist with a potency fourfold to eightfold that of Cimetidine. The debate on the comparative values of these two drugs has intensified (1-3). Minor side effects, such as headaches, skin rash, and dizziness, occur in about 3% of patients receiving ranitidine, but serious toxicity is rare. I report a case of hepatitis occurring after the use of ranitidine.A 77-year-old woman was hospitalized for fever, chills, nausea, and occasional vomiting. Twelve days before admission she had begun taking ranitidine, 150 mg twice daily, for treatment of...References1. MCCARTHY D. Ranitidine or Cimetidine [Editorial]. Ann Intern Med. 1983;99:551-3. LinkGoogle Scholar2. LIMA M. Ranitidine and Cimetidine [Letter]. Ann Intern Med. 1984;100:160-1. LinkGoogle Scholar3. ZELDISFRIEDMANISSELBACHER JLK. Ranitidine: a new H2-receptor antagonist. N Eng J Med. 1983;309:1368-73. CrossrefMedlineGoogle Scholar4. SIMONMULLERDAMMAN BPH. Safety profile of ranitidine. In: RILEY A, SALMON PR, eds. Ranitidine. New York: Excerpta Medica; 1982:181-9. (Current Clinical Practice series; vol. 1 ). Google Scholar5. BARRPIPER GD. Possible ranitidine hepatitis. Med J Aust. 1981;2:421. CrossrefMedlineGoogle Scholar6. ZIMMERMANMADDREY HW. Toxic and drug-induced hepatitis. In: SCHIFF L, SCHIFF ER, eds. Diseases of the Liver. 5th ed. Philadelphia: J. B. Lippincott Co.; 1982:621-92. Google Scholar7. LILLYHITCHJAVITT JDN. Cimetidine cholestatic jaundice in children. J Surg Res. 1978;24:384-7. CrossrefMedlineGoogle Scholar8. ZÜCHNER H. [Cholestatic hepatitis during treatment with cimetidine]. Dtsch Med Wochenschr. 1977;102:1788-9. MedlineGoogle Scholar9. VILLENEUVEWARNER JH. Cimetidine hepatitis. Gastroenterology. 1979;77:143-4. CrossrefMedlineGoogle Scholar10. LORENZINIJEZEQUELORLANDI IAF. Cimetidine-induced hepatitis: electron microscopic observations and clinical pattern of liver injury. Dig Dis Sci. 1981;26:275-80. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Leesburg Regional Medical Center Lake Community Hospital Leesburg, Florida. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRanitidine Induced Hepatotoxicity: A ReviewInflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal ModelsClinical significance of elevated alanine aminotransferase in blood donors: a follow-up studyRanidil 66337-59-3Ranitidine Treatment during a Modest Inflammatory Response Precipitates Idiosyncrasy-Like Liver Injury in RatsNephrotoxicity and Hepatotoxicity of Histamine H2 Receptor AntagonistsFatal Hepatitis Associated With RanitidineRapid progression to liver cirrhosis of toxic hepatitis due to ebrotidinePossible Cholestatic Injury From Ranitidine With a Review of the LiteratureHEPATOTOXICITY OF DRUGS USED IN THE TREATMENT OF GASTROINTESTINAL DISORDERSDrug-induced “Allergic hepatitis”Safety of acid-suppressing drugsRHepatitis following Treatments with Famotidine and Then CimetIDINEFamotidine-Induced Mixed Hepatocellular JaundiceCyclosporin A and Drug Interaction8 Acute and chronic drug-induced hepatitisZaltidine: An Effective but Hepatotoxic H 2 -Receptor AntagonistDrug-Induced CholestasisSafety of Nizatidine in Clinical Trials Conducted in the USA and EuropeEffects of three H2 antagonists on the isolated perfused rat liverRanitidine and Hepatic InjuryMARCOS A. SOUZA LIMA, M.D.Ranitidine and AgranulocytosisLINDA I. SHIELDS, M.D., JULIA A. FILES, M.D., DONALD C. DOLL, M.D., BERNARD R. GREENBERG, M.D.Gastrointestinal drugsEffects of H 2 -Receptor Antagonists on the Rat Liver after Partial Hepatectomy or Carbon Tetrachloride-Induced Hepatic InjuryRanitidine and HepatitisGEORGE N. KARACHALIOS, M.D.RANITIDINE HEPATOTOXICITY IN RENAL TRANSPLANT PATIENTRanitidine and HepatotoxicityDAVID Y. GRAHAM, M.D., ANTONE R. OPEKUN, P.A., J. LACEY SMITH, M.D., JIM T. SCHWARTZ, M.D.Ranitidine and the LiverMARCOS A. SOUZA LIMA, M.D.RANITIDINE AND HEPATOTOXICITYRanitidine, Acetaminophen, and HepatotoxicityJAMES E. BREDFELDT, M.D., CHRISTIAN VON HUENE, M.D. 1 August 1984Volume 101, Issue 2Page: 207-208KeywordsDrugsFeversHepatitis ANauseaRashesToxicityVomiting ePublished: 1 December 2008 Issue Published: 1 August 1984 PDF downloadLoading ...