tbuckley/cabot-search huggingface dataset:
Low-grade steatosis and major changes in portal flow as new prognostic factors in steroid-treated alcoholic hepatitis
Authors: Christophe Duvoux, Catherine Radier, Françoise Roudot–Thoraval, François Maille, Marie–Christine Anglade, Jeanne Tran Van Nhieu, Isabelle Rosa, Sylvie Hospitel, Issam Abd–Alsamad, Véronique Sitruk, Olivier Seror, Marianne Ziol, Hughes Blondon, Daniel Dhumeaux, Jean–Philippe Richardet
Journal: Hepatology (2004)

The aim of this study was to assess the prevalence and prognostic value of major alterations of portal flow in patients with steroid–treated alcoholic hepatitis. Fifty patients with severe, histologically proven alcoholic hepatitis were enrolled. Clinical data, liver test results, and hepatic Doppler ultrasound findings were collected at inclusion and at month 2. Patients were followed for 1 year or until death. Major changes in portal flow were defined as reversed or alternating flow in the portal trunk and/or in intrahepatic portal branches. Changes in portal flow were observed in 24 (48.0%) of 50 and 17 (39.5%) of 43 patients at inclusion and month 2, respectively. Univariate analysis showed that age older than 50 years, steatosis less than 20% on initial liver biopsy, presence of major changes in portal flow, Child–Turcotte–Pugh score higher than 12, factor V level higher than 45%, and hepatofugal splenic blood flow were associated with a lower 1–year survival. Cox regression analysis showed that steatosis &lt; 20% (relative hazard [RH] = 9.3, P = .0009) and major changes in portal flow (RH = 3.1, P = .04), were independently associated with poor survival. In conclusion , major changes in portal flow are frequent in patients with severe alcoholic hepatitis. Altered portal flow and steatosis &lt; 20% are new prognostic factors in steroid–treated alcoholic hepatitis and must be taken into account in patient management. (Hepatology 2004;40:1370–1378).
Abstract 5569: N-glycosylation in cultured cells and hepatocellular carcinoma
Authors: Zuzana Brnakova, Kevin B. Chandler, Slavka Bekesova, Juraj Lenco, Ionut Bebu, Ourania Kosti, Kirti Shetty, Brent E. Korba, Habtom W. Ressom, Rency S. Varghese, Milos V. Novotny, Radoslav Goldman
Journal: Cancer Research (2010)

Abstract Purpose: Incidence of hepatocellular cancer (HCC) continues to increase primarily due to hepatitis C viral (HCV) infection. Prognosis and survival of patients is highly affected by the disease stage at the time of diagnosis. Our mass spectrometric study evaluated N-glycans during the progression of HCV infection to cancer. Glycosylation of immunoglobulins and other serum proteins was examined in cultured cells and in serum of patients with hepatocellular carcinoma. Methods and Results: Protein associated N-glycans were released with PNGaseF and analyzed by MALDI-TOF/TOF analysis following solid phase permethylation. Analysis of less than 0.04 ml of serum led to relative quantification of 70 N-glycan structures. Immunoaffinity isolation of immunoglobulins and other serum proteins allowed us to study protein-specific glycosylation. Progression of HCV infection to HCC was strongly associated with changes in the glycosylation of immunoglobulins. In a pilot case-control study (25 HCC cases and 35 controls), N-glycosylation of eight glycans was significantly different in HCC compared to chronic liver disease controls. The glycosylation of serum proteins was further compared to the proteins secreted by the Huh-7.5 cell line. Conclusion: This study demonstrates mass spectrometric analysis of 70 N-glycans in serum, cultured cells, and isolated proteins. Our results show that the analysis of permethylated N-glycans helps to define changes associated with the progression of HCV infection to HCC. Evaluation of glycan abundance suggests the potential to use glycans for the detection of liver disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5569.
Factors Associated with Progression of Carcinoid Heart Disease
Authors: Jacob E. Møller, Heidi M. Connolly, Joseph Rubin, James B. Seward, Karen Modesto, Patricia A. Pellikka
Journal: New England Journal of Medicine (2003)

By releasing vasoactive substances into the circulation, carcinoid tumors can cause right-sided valvular heart disease. Factors associated with the progression of carcinoid heart disease are poorly understood. We conducted a retrospective study to identify such factors.Our sample included 71 patients with the carcinoid syndrome who underwent serial echocardiographic studies performed more than one year apart and 32 patients referred directly for surgical intervention after an initial echocardiographic evaluation. A score for carcinoid heart disease was determined on the basis of an assessment of valvular anatomy and function and the function of the right ventricle. An increase of more than 25 percent in the score between studies was considered suggestive of disease progression. Tumor progression was assessed on the basis of abdominal computed tomographic scans and changes in the level of urinary 5-hydroxyindoleacetic acid (5-HIAA), a metabolite of serotonin.Of the patients with serial echocardiographic studies, 25 (35 percent) had an increase of more than 25 percent in the cardiac score. As compared with patients whose score changed by 25 percent or less, these patients had higher urinary peak 5-HIAA levels (median, 265 mg per 24 hours [interquartile range, 209 to 593] vs. 189 mg per 24 hours [interquartile range, 75 to 286]; P=0.004) and were more likely to have biochemical progression (10 of 25 patients vs. 9 of 46, P=0.05) and to have received chemotherapy (13 of 25 vs. 10 of 46, P=0.009). Logistic-regression analysis showed that a higher peak urinary 5-HIAA level and previous chemotherapy were predictors of an increase in the cardiac score that exceeded 25 percent (odds ratio for each increase in 5-HIAA of 25 mg per 24 hours, 1.08 [95 percent confidence interval, 1.03 to 1.13]; P=0.009); odds ratio associated with chemotherapy, 3.65 [95 percent confidence interval, 1.74 to 7.48]; P=0.001).Serotonin is related to the progression of carcinoid heart disease, and the risk of progressive heart disease is higher in patients who receive chemotherapy than in those who do not.
Psychiatric Comorbidity, Family Dysfunction, and Social Impairment in Referred Youth With Oppositional Defiant Disorder
Authors: Ross W. Greene, Joseph Biederman, Stephanie Zerwas, Michael C. Monuteaux, Jennifer C. Goring, Stephen V. Faraone
Journal: American Journal of Psychiatry (2002)

The authors sought to achieve an improved understanding of the diagnosis of oppositional defiant disorder independent of its association with conduct disorder.Family interactions, social functioning, and psychiatric comorbidity were compared in clinically referred male and female subjects with oppositional defiant disorder alone (N=643) or with comorbid conduct disorder (N=262) and a psychiatric comparison group with neither oppositional defiant disorder nor conduct disorder (N=695).Oppositional defiant disorder youth with or without conduct disorder were found to have significantly higher rates of comorbid psychiatric disorders and significantly greater family and social dysfunction relative to psychiatric comparison subjects. Differences between subjects with oppositional defiant disorder alone and those with comorbid conduct disorder were seen primarily in rates of mood disorders and social impairment. Oppositional defiant disorder was a significant correlate of adverse family and social outcomes when comorbid disorders (including conduct disorder) were controlled.These results support the validity of the oppositional defiant disorder diagnosis as a meaningful clinical entity independent of conduct disorder and highlight the extremely detrimental effects of oppositional defiant disorder on multiple domains of functioning in children and adolescents.
Lyme Disease Simulating Septic Arthritis
Authors: Mitchell Stevens
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We report two recent cases that suggest that the clinical presentation of Lyme disease may simulate bacterial arthritis in children and should be considered in the differential diagnosis of children thought to have septic arthritis. In one patient the Lyme spirochete was demonstrated in tissue obtained by needle biopsy of bone; this patient also had iritis, another possibly septic manifestation of Lyme disease. <h3>Report of Cases.—</h3> Case1.—A 6-year-old boy was admitted to Babies Hospital because of increasing pain and swelling in the left knee over a two-week period following "minor injury." Aspiration by an orthopedist several days earlier revealed sterile fluid with a white blood cell count of 48 000/mm<sup>3</sup>(48×10<sup>9</sup>/L) (95% [0.95] polymorphonuclear leukocytes). He became febrile with a temperature of 38°C (101°F) one day prior to admission; his erythrocyte sedimentation rate (ESR) was 90 mm/ h. Repeated joint fluid examination yielded
An ethical and prudential argument for prioritizing the reduction of parasite-stress in the allocation of health care resources
Authors: Russell Powell, Steve Clarke, Julian Savulescu
Journal: Behavioral and Brain Sciences (2012)

Abstract The link between parasite-stress and complex psychological dispositions implies that the social, political, and economic benefits likely to flow from public health interventions that reduce rates of non-zoonotic infectious disease are far greater than have traditionally been thought. We sketch a prudential and ethical argument for increasing public health resources globally and redistributing these to focus on the alleviation of parasite-stress in human populations.
Early American Medical Imprints: A Guide to Works Printed in the United States, 1668-1820
Authors: John H. Talbott
Journal: JAMA (1962)

The History of Medicine Division of the National Library of Medicine has prepared a bibliography of imprints published in the United States before 1821. Robert B. Austin, who has recently retired after 30 years of service to the Library, was largely responsible for the volume. Approximately 70 libraries or societies are the repositories for the items listed, including the Royal College of Surgeons of England. There are several imprints that seem to me especially worthy of note. Undoubtedly, others would compile quite a different list of interests. The activities of county and state medical societies and county and city health departments are well documented in this period. Nine editions of William Cullen's<i>First Lines of the Practice of Physic</i>were published between 1781 and 1816 and 3 editions of his<i>Synopsis of Methodical Nosology</i>between 1783 and 1793. Daniel DeFoe's story of the 1665 epidemic of the plague in London
GROWTH CHARACTERISTICS OF POLIOVIRUS IN H<scp>E</scp>L<scp>A</scp> CELLS: NUCLEIC ACID METABOLISM
Authors: H. F. Maassab, Philip C. Loh, W. Wilbur Ackermann
Journal: The Journal of Experimental Medicine (1957)

The RNA and DNA contents of the nucleus and cytoplasm of the HeLa cell were determined. The rates of incorporation of P(32) into the various nucleic acid fractions were established for the ordinary HeLa cell maintained under a set of standard conditions. The changes in the rates of incorporation of P(32) and in the amounts of RNA and DNA which occurred subsequent to infection with poliovirus were followed throughout the infectious cycle. These changes were correlated with the intracellular appearance of the newly formed virus. A net synthesis of RNA occurred in the cytoplasmic component of the cell. The increase was detectable 2 hours before the first appearance of demonstrable virus and reached a maximum (2.5 times normal) at 6 hours. Viral increase was not maximal before the 7th hour after infection.
In vivo imaging of cerebral "peripheral benzodiazepine binding sites" in patients with hepatic encephalopathy
Authors: Annachiara Cagnin, Simon D Taylor-Robinson, Daniel M Forton, Richard B Banati
Journal: Gut (2005)

<b>Background and aim:</b> One proposed mechanism whereby hepatic encephalopathy (HE) leads to loss of brain function is dysregulated synthesis of neurosteroids. Mitochondrial synthesis of neurosteroids is regulated by "peripheral benzodiazepine binding sites" (PBBS). Expressed in the brain by activated glial cells, PBBS can be measured in vivo by the specific ligand [<sup>11</sup>C]<i>(R)-</i>PK11195 and positron emission tomography (PET). Recently, it has been suggested that PBBS expressing glial cells may play a role in the general inflammatory responses seen in HE. Therefore, we measured PBBS in vivo in the brains of patients with minimal HE using [<sup>11</sup>C]<i>(R)-</i>PK11195 PET. <b>Methods:</b> Five patients with minimal HE and biopsy proven cirrhosis of differing aetiology were assessed with a neuropsychometric battery. Regional expression of PBBS in the brain was detected by [<sup>11</sup>C]<i>(R)-</i>PK11195 PET. <b>Results:</b> All patients showed brain regions with increased [<sup>11</sup>C]<i>(R)-</i>PK11195 binding. Significant increases in glial [<sup>11</sup>C]<i>(R)-</i>PK11195 binding were found bilaterally in the pallidum, right putamen, and right dorsolateral prefrontal region. The patient with the most severe cognitive impairment had the highest increases in regional [<sup>11</sup>C]<i>(R)-</i>PK11195 binding. <b>Conclusion:</b> HE is associated with increased cerebral binding of [<sup>11</sup>C]<i>(R)-</i>PK11195 in vivo, reflecting increased expression of PBBS by glial cells. This supports earlier experimental evidence in rodent models of liver failure, suggesting that an altered glial cell state, as evidenced by the increase in cerebral PBBS, might be causally related to impaired brain functioning in HE.
Cost-Effectiveness Analysis of Augmentation Therapy for Severe α<sub>1</sub>-Antitrypsin Deficiency
Authors: Thomas R. Gildea, Kenneth M. Shermock, Mendel E. Singer, James K. Stoller
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

A Markov-based decision model was created to assess the cost-effectiveness of augmentation therapy (Aug) for severe alpha1-antitrypsin deficiency, comparing strategies of: (1) no Aug, (2) Aug for life, and (3) Aug until FEV1 is below 35% predicted. A hypothetical cohort of 46-year-old patients with FEV1 49% predicted was followed over time using Monte Carlo simulation across five possible health states: (1) FEV1 50 to 79% predicted, (2) FEV1 35 to 49% predicted, (3) FEV1 below 35% predicted, (4) status-post-lung transplantation, and (5) dead. Treatment for life yielded 7.19 quality-adjusted life-years (QALYs) and cost 895,243 dollars. Treating until FEV1 is below 35% predicted cost 511,930 dollars and produced 6.64 QALYs. "No Aug" cost 92,091 dollars with 4.62 QALYs. The incremental cost-effectiveness ratio was 207,841 dollars/QALY for Aug until FEV1 is below 35% predicted and 312,511 dollars/QALY for the "Aug for life" strategy. In all sensitivity analyses, the incremental cost-effectiveness ratio for Aug for life exceeded 100,000 dollars. The cost of Aug needed to be reduced from 54,765 dollars to 4,900 dollars for the "Aug for life" strategy to be considered cost-effective. We conclude that, compared with other conventionally used health interventions, Aug is relatively less cost-effective. These results should encourage the development of more clinically and cost-effective therapies for alpha1-antitrypsin deficiency.
Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL
Authors: Willem A. Dik, Bertrand Nadel, Grzegorz K. Przybylski, Vahid Asnafi, Piotr Grabarczyk, Jean Marc Navarro, Brenda Verhaaf, Christian A. Schmidt, Elizabeth A. Macintyre, Jacques J. M. van Dongen, Anton W. Langerak
Journal: Blood (2007)
Surviving Cancer or Other Serious Illness: A Review of Individual and Community Resources
Authors: S. S. Coughlin
Journal: CA A Cancer Journal for Clinicians (2008)

In order to provide appropriate individual and community support for cancer survivors, there is a great need to better understand how people who have survived cancer or other serious illness adapt positively to health challenges and to identify effective approaches for helping people cope with health challenges over their lifetime. Studies have identified a number of personal factors that are associated with resilience, increased quality of life, and positive adaptation to illness. Of particular interest is the ability of individuals to survive or even thrive despite an adverse event, as influenced by both individual factors such as resiliency and external factors like social support. The experience of having a potentially life-threatening illness can lead to positive adaptation and increased ability to thrive despite difficult circumstances. The cancer survivorship movement and the cancer community in general provide important resources for improving quality of life and alleviating human suffering and distress among patients and survivors and for adding personal meaning and hope to people's lives.
Resection and reconstruction of the sternum: case report.
Authors: V Beltrami, G Gidaro
Journal: Thorax (1976)

The case history of a 67-year-old man who underwent a subtotal sternectomy for a tumour of the manubrium and left clavicle is reported. Histological examination revealed a highly undifferentiated metastatic carcinoma: the original tumour was not discovered but the patient was in good condition 10 months after operation. Adequate replacement and stabilization of the chest wall was obtained with autotransplantation of the tibia and muscle flaps.
Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia
Authors: Paul S. Aisen
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Misleading Diagnosis of Ischemia by Tc-99m Tetrofosmin SPECT Resulting From a Voluminous Hiatal Hernia
Authors: Jaime Ort??n, David Fuster, ??frica Mux??, Xavier Setoain, Pilar Paredes, Joan Duch, Francesca Pons
Journal: Clinical Nuclear Medicine (2006)

Hiatal hernia occurs when abdominal structures protrude into the thoracic cavity through a defect on the diaphragm. Few cases of hiatal hernia have been published as a casual finding using myocardial imaging agents. We present a case in which a hiatal hernia was suspected while performing a Tc-99m tetrofosmin gated-SPECT study in a patient referred to our department to rule out coronary artery disease. The study was initially suggestive of myocardial ischemia. A double-contrast thoracoabdominal CT showed the presence of a major hiatal hernia, which matched the myocardial SPECT findings.
WILL NOISE DAMAGE ONE'S HEARING?
Authors: E. GROVE
Journal: JAMA (1949)

Is noise driving you crazy? This was the subject of a syndicated article in a newspaper Sunday supplement of August 1947. Psychiatrists and psychologists who have studied the problem regard noise as one of the most serious threats to our health. Long-continued noise menaces health and destroys efficiency. It produces fatigue, which impairs efficiency. It encourages inattention and lack of concentration, which is again reflected in lack of efficiency. It promotes absenteeism and again impairs efficiency. The nervous system is not constituted to take this sort of battering. One becomes jumpy, jittery and irritable under the impact of continuous noise. Neurasthenia and psychasthenia develop which are not incomparable to battle fatigue. Podolsky said, "It is not an exaggeration at all to say that often cases of insanity are caused by nervous systems which cannot adjust themselves to the constant bombardment of noise." Business executives realize that noise causes inattention, lack
Acquired Factor IX Deficiency in the Nephrotic Syndrome
Authors: ETHAN A. NATELSON
Journal: Annals of Internal Medicine (1970)

In a patient with the nephrotic syndrome prolonged whole blood clotting and defective intrinsic thromboplastin generation resulted from an acquired deficiency of factor IX. His urine and that from eight additional patients with massive proteinuria, in contrast to normal urine, contained a procoagulant with factor IX activity. The extraction of this substance as a barium sulfate adsorbate from urine is described, and its ability to correct the abnormality in thromboplastin generation of patients with congenital factor IX deficiency and elicit rabbit antisera that inactivate human serum factor IX is demonstrated. These findings support excessive urinary loss of factor IX as a potential cause for acquired factor IX deficiency in certain patients with massive proteinuria.
DIAGNOSTIC ACCURACY OF 64 SLICE MULTIDETECTOR CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY FOR EVALUATION OF CORONARY ARTERY STENOSIS IN PERSONS WITH DIABETES AS COMPARED WITH NON- DIABETICS
Authors: Mohit Gupta, Yalcin Hacioglu, Naser Ahmadi, James Min, Faye Lin, Matthew Budoff
Journal: Journal of the American College of Cardiology (2010)
More Evidence Links NSAID, Estrogen Use With Reduced Alzheimer Risk
Authors: Joan Stephenson
Journal: JAMA (1996)

NEW FINDINGS from a long-term, prospective observational study on aging indicate that men and women who take nonsteroidal anti-inflammatory drugs (NSAIDs) and women who receive estrogen replacement therapy have a markedly reduced risk of developing Alzheimer disease. The results, reported at the annual meeting of the American Academy of Neurology, in San Francisco, Calif, confirm suggestions from previous studies that the agents may help prevent the disease or slow its progression. Although the investigators caution that their work shows an association rather than a causal link between these drugs and the disease, they say that hints that these agents may have neuroprotective effects against the devastating illness are promising enough to warrant clinical trials to look for definitive answers. Earlier research suggesting a link between inflammation-fighting drugs and a reduced risk of Alzheimer disease included a 1994 Duke University study of 50 sets of elderly twins. This study found that