tbuckley/cabot-search huggingface dataset:
Antiphospholipid antibodies and HLA associations in primary Sjogren's syndrome.
Authors: R.A Asherson, H.M Fei, H.L Staub, M.A Khamashta, G.R Hughes, R.I Fox
Journal: Annals of the Rheumatic Diseases (1992)

Blood samples from 65 patients with primary Sjögren's syndrome were evaluated for the presence of antiphospholipid antibodies. Increased levels of antiphospholipid antibodies were found in 13 of 65 (20%) of patients. These antiphospholipid antibodies were predominantly of the IgA isotype, in contrast with the IgG isotype antiphospholipid antibodies found in patients with systemic lupus erythematosus (SLE). The presence of IgA antiphospholipid antibodies in the patients with primary Sjögren's syndrome was not significantly associated with arterial or vascular thrombosis, nor peripheral or central nervous system vasculitis. There was no association with laboratory determined features such as lupus anticoagulant or false positive results of the Venereal Disease Research Laboratory (VDRL) test. Oligonucleotide specific DNA amplification and hybridisation with allele specific probes was used to examine the HLA-D antigens occurring in this group of patients with primary Sjögren's syndrome. Of 13 patients with antiphospholipid antibodies, seven had the genotype HLA-DR2/DR3. However, compared with the whole group of 65 patients with Sjögren's syndrome, no increased occurrence of haplotype DR2 or DR3 was noted. These results suggest that gene interaction between DR2 and DR3 may play a part in the production of antiphospholipid antibodies in patients with Sjögren's syndrome. In contrast with patients with SLE, the IgA antiphospholipid antibodies in patients with Sjögren's syndrome are not risk factors for thrombosis or vasculitis. The presence of IgA antiphospholipid antibodies in patients with Sjögren's syndrome probably reflects its production at mucosal sites of inflammation and the absence of vasculopathy may be due to the inability of IgA antibodies to activate complement.
Lower Serum Levels of Angiopoietin Like Protein-6 are Associated with Significant Coronary Artery Disease
Authors: Aycan Fahri Erkan, Uğur Erçin, Murat Uğurlu, Aslı Tanındı, Berkay Ekici, Bülent Çelik, Ayşe Bilgihan, Hasan Fehmi Töre
Journal: Journal of the American College of Cardiology (2013)
Credit ratings would help to identify failing foundation trusts early, says Monitor
Authors: N. Hawkes
Journal: BMJ (2012)

Credit rating agencies could be used to assess the financial soundness of NHS foundation trusts, the regulator Monitor has suggested in a consultation paper.

It says that agencies such as Standard & Poor’s, Moody’s, or Fitch could be given access to a trust’s books and issue assessments of the trust’s credit rating. Such ratings are normally used by investors to help decide whether governments or corporations have the ability and willingness to repay financial obligations such as bonds. The agencies were heavily criticised for failing to identify the high risks being run by banks before the economic crisis of 2008.

The suggestion that they could provide a measure of the financial risk being run by foundation trusts appeared in a consultation paper issued by Monitor on 16 December last year as part of its proposed licensing regime for foundation trusts. …
A Family Practice Residency Network
Authors: John P. Geyman
Journal: JAMA (1978)

The Department of Family Medicine at the University of Washington School of Medicine has developed a regional network of affiliated family practice residency programs in the Pacific Northwest. Collaborative efforts among the seven participating programs are directed to common needs such as curriculum development, sharing of educational resources, program evaluation, problem-solving of operational programs, and coordination of resident rotations. This family practice residency network is a logical and necessary extension of the program that has been developed in Washington, Alaska, Montana, and Idaho for teaching medical students. Regional undergraduate and graduate teaching programs in family practice represent an important role for the university relating to its surrounding region through the collaborative efforts of the medical school and participating hospitals and physicians in the community.
Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death
Authors: Gro Gausdal, Bjørn Tore Gjertsen, Emmet McCormack, Petra Van Damme, Randi Hovland, Camilla Krakstad, Øystein Bruserud, Kris Gevaert, Joël Vandekerckhove, Stein Ove Døskeland
Journal: Blood (2008)
Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome
Authors: Jan K. Teller, Claudio Russo, Laura M. Debusk, Giovanna Angelini, Damiano Zaccheo, Francesca Dagna-Bricarelli, Pietro Scartezzini, Stefano Bertolini, David M.A. Mann, Massimo Tabaton, Plerluigi Gambetti
Journal: Nature Medicine (1996)
Oligodeoxynucleotide-mediated inhibition of c-myb gene expression in autografted bone marrow: a pilot study
Authors: Selina M. Luger, Stephen G. O'Brien, Janina Ratajczak, Mariusz Z. Ratajczak, Rosemarie Mick, Edward A. Stadtmauer, Peter C. Nowell, John M. Goldman, Alan M. Gewirtz
Journal: Blood (2002)
Growth of Yeast-Like Fungi in the Stomach
Authors: N. Gabrielsson
Journal: Endoscopy (1971)

Intraluminal growth of yeast-like fungi in the stomach was demonstrated in 30 cases by gastro-photography. The roentgenographic and endo-scopic findings in these cases are compared and differential diagnostic possibilities discussed. The gastrophotographic appearance of yeast-like fungi is characteristic and allows diagnosis even before the growth is massive and causes symptom. They may anyhow be important, as other leisons may be covered or mimicked by fungi both on roentgen examination and at gastrophotography.
BROMIDE DELIRIUM AND OTHER BROMIDE PSYCHOSES
Authors: Max Levin
Journal: American Journal of Psychiatry (1933)

Seven cases of bromide delirium and one case of bromide hallucinosis are presented. In addition to the commonly known symptoms of delirium, the patients in the delirious group showed to a noteworthy extent two disturbances. (1) Disturbances of sensation (referring not to hallucinations, but to subjective difficulty in recognizing colors, macropsia, micropsia, etc.). (2) Disturbances of the association of ideas of the type commonly seen in schizophrenia. It is suggested that these two disturbances are among the "ingredients" of disorientation. The delirious individual misidentifies objects and situations partly because he does not perceive well and partly because, owing to faulty association of ideas, he improperly discriminates that which he has perceived. Consideration is given to the following topics: (1) How many clinical types of bromide psychosis are known to exist? We may say with certainty that in addition to "simple bromide intoxication" there are delirium and hallucinosis. There seems to be a possibility that bromide intoxication may also manifest itself as a paranoid state. In two of my cases (Cases 2 and 7) the delirium merged into a transitory paranoid state. In neither of these cases was there evidence of a paranoid state prior to the delirium. In another case (Case 4) the delirium merged into a paranoid state which, at the present writing, has been in existence over 11 months without yet having begun to subside; in this case the patient had a major psychosis before the onset of the delirium, and the existence of paranoid symptoms prior to the delirium has not been ruled out. As far as I know, no case has been reported in which a paranoid state supervened during bromide intoxication without a previous delirium. The distinction between "paranoid disorientation" and delirious disorientation is demonstrated. (2) Is there a "post-intoxication psychosis"? The possibility of this is suggested by Case 5, in which a woman, previously nonpsychotic, developed a bromide delirium which, four weeks after the discontinuance of bromides, merged into a chronic delirium with marked psychomotor embarrassment. It seems possible that under certain conditions bromide intoxication (like any other toxic process) may precipitate a chronic psychosis which remains long after the intoxication has subsided. (3) The etiological factors of bromide psychoses are reviewed. Attention is called to several objections to the recently proposed hypothesis of the occurrence of "withdrawal delirium."
A SIMPLE, INEXPENSIVE POWER UNIT FOR ELECTRICALLY LIGHTED SURGICAL INSTRUMENTS
Authors: Arthur D. Gray
Journal: JAMA (1923)

That most of the transformers and current controllers designed for use with electrosurgical instruments have some unsatisfactory features is a fact well known to every one who has occasion to use them. Most of these appliances, constructed on the resistance principle, are subject to fluctuations in the main power line, which are proportionately reflected in the instrument circuit and often result in the burning out of a lamp. On a wet operating room floor they may "ground," to the extreme discomfort of the patient and the annoyance of the surgeon. Although I designed the apparatus described here for use primarily with urologic instruments, it serves equally well for any of the small diagnostic lamps. It is made up from ordinary dry batteries and stock radio parts that can be purchased anywhere. After the rheostat has been mounted on the panel, the latter is fastened to the dry cells with strips
Operable lung cancer
Authors: N. Martini
Journal: CA A Cancer Journal for Clinicians (1993)

Lung cancer is the most common cause of death from cancer for both males and females in the United States. Left untreated, most patients die within one year of diagnosis with a median survival of less than six months. Surgery remains the most effective method for controlling the primary tumor in most cases. This article reviews the role of surgical treatment for the various stages of lung cancer.
Prescribing costs when computers are used to issue all prescriptions.
Authors: J. B. Donald
Journal: BMJ (1989)

The aim of the study was to see whether the use of a computer to issue prescriptions in conjunction with a computerised, customized drug formulary affects prescribing costs. Data on prescribing costs were obtained from the Scottish Prescription Pricing Bureau for 1978-87. A microcomputer system was introduced into the practice in 1983 and used initially to issue repeat prescriptions, but from 1985 onwards a new system was added to issue all prescriptions; a personal computerised drug formulary was developed in 1983. Personal prescribing costs before and after computerisation were compared with those of the other partners and those of the Lothian Health Board and Scotland combined. The prescribing costs of the partners and Lothian Health Board and Scotland combined increased almost linearly in line with inflation from 1978 to 1987. Personal prescribing costs increased steadily until 1983, when repeat prescriptions were issued by computer, and remained static for a year. Thereafter they increased steadily until 1985, when all prescriptions were issued by computer, and then showed a steady and sustained fall. Personal prescribing costs were 21.5% lower than those of the partners in 1986 and 29.5% lower in 1987. Prescribing costs were reduced when a computer was used to issue all prescriptions in conjunction with a personal, computerised formulary.
Drug Effectiveness and Safety
Authors: ROBERT L. NORTH
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 September 1973Drug Effectiveness and SafetyROBERT L. NORTH, M.D.ROBERT L. NORTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-3-455_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Morrelli's discourse on propranolol (1) is an interesting one. Two pages of references accompany a three-page contribution, the major substance of which is a set of rather offhand opinions and recommendations, for which little documentation is provided. "The physician in practice may experiment. . . ."; "The FDA should not be unduly pressured. . . ."; "the willingness of medical journals to publish uncritical studies . . . ."Virtually identical comments could be made about any drug in the pharmacopeia. Different studies do indeed show conflicting results, and it is doubtful that any drug is...References1. MORRELLI H: Propranolol. Ann Intern Med 78:913-917, 1973 LinkGoogle Scholar2. BLOOM B and PETERSON O: End results, cost and productivity of coronary-care units. N Engl J Med 288:72-78, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT L. NORTH, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1973Volume 79, Issue 3Page: 455-456KeywordsDrug safetyDrugsFood and Drug Administration ePublished: 1 December 2008 Issue Published: 1 September 1973 PDF downloadLoading ...
THE HISTORY OF THE INVENTION AND OF THE DEVELOPMENT OF THE OPHTHALMOSCOPE.
Authors: HARRY FRIEDENWALD
Journal: JAMA (1902)

The marvelous advance that modern medicine has made is due in great part to the invention of instruments of precision. They have lent delicacy and accuracy to our methods of examination and have opened new fields that were closed to our unaided senses. When early in the last century Laennec invented the stethoscope, he gave us the means of discovering morbid processes within the body and thus revolutionized internal medicine. Helmholtz's invention of the ophthalmoscope did the same for ophthalmology. In both cases the field had long been cleared and there was no reason why the instrument should not have been invented earlier, but that in the one case it required the genius of Laennec and in the other the versatile and profoundly scientific talent of Helmholtz to lay bare simple facts which every tyro saw plainly after they had once been pointed out. As the invention of the stethoscope
Biochemical and Pharmacological Variations in Manic-Depressive Illness
Authors: CHRISTIAAN D. VAN DER VELDE, MALCOLM W. GORDON
Journal: American Journal of Psychiatry (1972)

The response of 21 manic-depressives to imipramine was followed over a period of two years, during which both manic and depressed states were treated. Most patients responded differently to this treatment at different times. The variation in response is considered in the context of a hypothecated biochemical instability in the manic-depressive that is manifest in behavioral, pharmacological, and biochemical measures.
Quality of Life (QOL) in Ragweed Allergic Patients Treated with Captisol-Enabled® Budesonide Nasal Solution (32μg/spray) when Exposed to Ragweed Pollen in an Environmental Exposure Chamber (EEC) Using an EEC-Specific Rhinoconjunctivitis Quality of Life Questionnaire (EEC-RQOLQ)
Authors: A SALAPATEK, S MCCUE, D PATEL, P PATEL, J PIPKIN, R ZIMMERERJR
Journal: Journal of Allergy and Clinical Immunology (2008)
A meeting too far
Authors: E. Lester
Journal: BMJ (1995)

Everyone agrees that doctors should be involved in management in the reformed health service but it depends what you mean by management. Since the 1991 reorganisation there has been an enormous increase in the number of non-medical managers. They spend much of their time in meetings. So do many doctors, but unfortunately our numbers have not similarly increased and the patients are still there.

Before the reforms we had a medical staff committee composed of the consultant medical staff in the district. We met once a month at 5 o'clock and talked for two hours, mostly about how little notice the administration, as it was then, took of our views on any matter concerning the running of the hospital. Not that we often had a united coherent view.

Now that we are a trust hospital the medical …
Pain after subcutaneous injection of erythropoietin.
Authors: S F Lui, C B Leung, P K Li, K N Lai
Journal: BMJ (1991)

selective damage to specific cell populations has not occurred.Analysis of incorporated bromodeoxyuridine with monoclonal antibodies requires the DNA to be denatured (commonly by exposure to acid).Unfortunately, this step is inherently prone to error as it leads to considerable cell loss and possible damage to antigenic sites.Also, sensitivity to DNA denaturation varies across the cell cycle4for example, cells fixed in late S phase will have more denatured DNA.Our experience in colorectal tumour tissue has shown that labelling indices obtained with both flow cytometry and immunohistochemistry results in reproducible variations that are dependent on acid concentration.The intention of this letter is not to discourage the use of thymidine analogues in cell proliferation analysis but simply to make interested parties aware of the inherent caveats in this methodology.Advances in the clinical application of bromodeoxyuridine will depend on a closer investigation of these enigmas at a tissue specific level.The desire for data should not tempt us to explain the answers before we have asked the questions.
Effect of a single ingestion of alcohol on iron absorption
Authors: Antonio Celada, Hans Rudolf, Alfred Donath
Journal: American Journal of Hematology (1978)

The effect of alcohol on inorganic and organic iron absorption was studied in 70 subjects, using a whole-body counter technique. The mean iron absorption of a test dose was 24.44%, while in the presence of whisky, absorption fell to 9.73% (P less than 0.0001). Absorption of a test dose in the presence of whisky without alcohol was 10.14% (P less than 0.0001). The alcohol in whisky, therefore, was not responsible for the diminished iron absorption (P greater than 0.20). The absorption of the iron contained in wine with alcohol was 73.31 microgram and wine without alcohol was 67.50 microgram. The difference was not statistically significant (P greater than 0.20). The absorption of inorganic iron contained in a test meal was 165.55 microgram and was not changed in the presence of ethanol (151.35 microgram) (P greater than 0.10). However, the presence of ethanol affected the absorption of heme iron: 538.68 microgram compared with 442.41 microgram with ethanol (P less than 0.0001). These studies show that the acute ingestion of ethanol does not influence the absorption of inorganic iron, while it does diminish the absorption of the organic form.
Alcohol Use, Thiamine Deficiency, and Cognitive Impairment
Authors: Francesco Panza
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
John Graham Jones
Authors: Jeremy Jones, Peter N G Jones, Philippa Bevan
Journal: BMJ (2006)

Plastic surgeon and creator of the first collection of American penny arcade antique toys Before movies and television, small town Americans went to penny arcades for amusement, dropping coins into devices that entertained them by making mechanical figures move or-like today's slot machines-rewarded them with more coins if they played a game correctly.The devices were also found in bars, amusement parks, restaurants, and hotels.Their popularity peaked before the first world war and they went out of style when prohibition closed America's bars.When James Smith was a boy in East Liverpool, Ohio, the son of a dignified banker, he often rode the trolley car across the state line to an amusement park in Chester, West Virginia, where he enjoyed dropping pennies and nickels (five cent pieces) into machines that told fortunes, tested one's strength, played games, or offered penny candy.He said he loved the challenge of trying to beat the machines, but his father discouraged his son's gaming habits.
Abstract LB-199: SN38-dextran prodrug synthesis and cell delivery in a murine metastatic pancreatic cancer model
Authors: Tej B. Shrestha, Matthew T. Basel, Sivasai Balivada, Gwi Moon Seo, Marla Pyle, Stefan H. Bossmann, Deryl L. Troyer
Journal: Cancer Research (2011)

Abstract Enzyme activated prodrugs have been investigated and sought after as highly-specific, low side effect treatments, especially for cancer therapy. We synthesized an SN38-dextran prodrug and utilized it in a cell delivery system that can carry both the prodrug and an activating enzyme to the cancer site. For delivery of our prodrug, we engineered Raw264.7 cells (mouse monocyte/macrophage like cells, Mo/Ma) to express intracellular rabbit carboxylesterase (InCE), which cleaves the prodrug to activate SN38. InCE expression was regulated by the TetOn® system, which silences the gene unless a tetracycline, such as doxycycline is present. To test the system, a murine pancreatic cancer model was generated by intraperitoneal (i.p.) injection of Pan02 cells. Engineered Mo/Ma cells were loaded with the SN38-dextran prodrug and were injected i.p. into the mice. Two days following injection, doxycycline was given i.p. to activate the InCE, which in turn activates the prodrug into active SN38. A survival study demonstrated that this system significantly increased survival in a murine pancreatic cancer model, with an average post-diagnosis life expectancy increase of 20%. Thus, for the first time, a prodrug/activating enzyme system self-contained within tumor-homing cells has been demonstrated that can significantly prolong the life of i.p. pancreatic tumor bearing mice. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-199. doi:10.1158/1538-7445.AM2011-LB-199