Chemotherapy Combined with Chest Irradiation for Locally Advanced Non-Small Cell Lung Cancer
Authors: Daniel C. Ihde
Journal: Annals of Internal Medicine (1991)

Editorials1 November 1991Chemotherapy Combined with Chest Irradiation for Locally Advanced Non-Small Cell Lung CancerThe End of the Beginning?Daniel C. Ihde, MDDaniel C. Ihde, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-9-737 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLung cancer is the second most common cancer and the most common fatal cancer in the United States (2). Three fourths of these malignancies are pathologically diagnosed as squamous, large cell, or adenocarcinoma. These histologic subtypes are often viewed as a single entity, non-small cell lung cancer, because they exhibit similar biologic behavior. In contrast to small-cell carcinoma, they often present as sufficiently localized neoplasms that may be approached surgically with curative intent but are relatively unresponsive to cytotoxic chemotherapy.Between one fourth and one third of patients with non-small cell lung cancer do not have clinically detectable distant metastatic...References1. Beck E; ed. Bartlett's Familiar Quotations. 15th ed. Boston: Little, Brown & Company; 1980:746. Google Scholar2. BoringSquiresTong CTT. Cancer statistics, 1991. CA. 1991;41:19-36. Google Scholar3. IhdeMinna DJ. Non-small cell lung cancer. Part I: Biology, diagnosis, and staging. Curr Probl Cancer. 1991;15:61-104. MedlineGoogle Scholar4. . Lung cancer. In: Beahrs OH, Henson DE, Hutter RV, Myers MH; eds. Manual for Staging of Cancer. 3d ed. Philadelphia: J.B. Lippincott; 1988:115-21. Google Scholar5. IhdeMinna DJ. Non-small lung cancer. Part II: Treatment. Curr Probl Cancer. 1991;15:105-54. MedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: National Cancer Institute Bethesda, MD 20892 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDefinitive Chemoradiation for the Treatment of Locally Advanced Non–Small-Cell Lung CancerA phase I/II trial of neoadjuvant chemotherapy with cisplatin and vinorelbine followed by accelerated irradiation for patients with inoperable nonsmall cell lung carcinomaAnalysis of neuroendocrine markers, HER2 and CEA before and after chemotherapy in patients with stage IIIA non-small cell lung cancer: A Cancer and Leukemia Group B studyConcurrent daily carboplatin and accelerated hyperfractionated thoracic radiotherapy in locally advanced nonsmall cell lung cancerComparison of induction chemotherapy before radiotherapy with radiotherapy only in patients with locally advanced squamous cell carcinoma of the lungA randomized Phase II study of ifosfamide/mesna/cisplatin plus G-CSF or etoposide/cisplatin plus G-CSF in advanced non-small cell lung cancer: A Cancer and Leukemia Group B studyPromising new agents in the treatment of non-small cell lung cancerA phase I trial of ifosfamide, mesna, and cisplatin in advanced non-small cell lung cancer a cancer and leukemia group B studyPrognostic Factors in Lung CancerDoes Radiation Increase Survival in Nonresectable Lung Cancer?George G. Spellman Jr, MD 1 November 1991Volume 115, Issue 9Page: 737-739KeywordsAdenocarcinomaBehaviorBiologicsCancer chemotherapyChemotherapyCytotoxic chemotherapyEpithelial cellsLung and intrathoracic tumorsNon small cell lung cancerThorax Issue Published: 1 November 1991 PDF DownloadLoading ...