Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia
Authors: Cesare Masala
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 May 1989Anticardiolipin Antibodies and Pneumocystis carinii PneumoniaCesare Masala, MD, Maurizio Sorice, MD, Maria A. Di Prima, MD, Luisa Lenti, MD, Roberta Misasi, MD, Carlo Contini, MD, Vincenzo Vullo, MDCesare Masala, MDSearch for more papers by this author, Maurizio Sorice, MDSearch for more papers by this author, Maria A. Di Prima, MDSearch for more papers by this author, Luisa Lenti, MDSearch for more papers by this author, Roberta Misasi, MDSearch for more papers by this author, Carlo Contini, MDSearch for more papers by this author, Vincenzo Vullo, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-9-749_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with infectious mononucleosis and postulated the existence of cross-reactions between infectious (viral) antigens and cardiolipin. We report here our experience concerning immunologic and biochemical similarities between Pneumocystis carinii organisms and cardiolipin. We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among those patients who had active P. carinii pneumonia (2). To test the cross-reactive hypothesis, we did several experiments.In the first set of experiments, rabbits were immunized with an antigen fromP. cariniiin Freund's adjuvant prepared according...References1. MisraVenablesWatkinsMaini RPRR. Autoimmunity to cardiolipin in infectious mononucleosis. Lancet. 1987;2:629. CrossrefMedlineGoogle Scholar2. Di PrimaSoriceVulloMastroianniAmendoleaMasala MMVCMC. Anticardiolipin antibody in AIDS: a marker of Pneumocystis carinii infection? J Infect. 1988:[In press]. Google Scholar3. WalzerRutledgeYanedaStahr PMKB. Pneumocystis carinii: new separation method from lung tissue. Exp Parasitol. 1979;47:356-68. CrossrefMedlineGoogle Scholar4. Mojon M. Sierodiagnostic des affections a Pneumocystis carinii. Premiers resultats. Lyon, France: Universitè Claude Bernard; 1976. Google Scholar5. LoizouMcCreaRudgeReynoldsBoyleHarris SDARCE. Measurement of anticardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol. 1985;62:738-45. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University "La Sapienza" Rome 00161 Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntiphospholipid antibodies investigation in Pneumocystis jirovecii carriersSpecificity of anti-phospholipid antibodies in infectious mononucleosis: a role for anti-cofactor protein antibodiesThe Lipids of Pneumocystis cariniiSplenic infarction associated with anticardiolipin antibodies in a patient with acquired immunodeficiency syndromeAnticardiolipin antibodies and acquired immunodeficiency syndrome: Prognostic marker or association with HIV infection?Anticardiolipin antibodies and Pneumocystis carinii pneumonia in patients with AIDSFactors related to the presence of autoantibodies in patients with chronic mental disorders 1 May 1989Volume 110, Issue 9Page: 749-749KeywordsAIDSAntibodiesAntigensPneumocystisPneumocystis carinii pneumoniaPneumoniaRabbits Issue Published: 1 May 1989 PDF DownloadLoading ...