tbuckley/cabot-search huggingface dataset:
Expert views as expressed in a lay consensus statement
Authors: Kjell Aas
Journal: Allergy (1994)

AllergyVolume 49, Issue 8 p. 573-575 Free Access Expert views as expressed in a lay consensus statement Nordic Consensus Statement on investigation of allergy and other disorders of hypersensitivity Kjell Aas MD, Kjell Aas MD Research Institute of Pediatric Allergology, Pulmonology and Environment (FIPALM), Voksentoppen Ullveien 14 0394 Oslo NorwaySearch for more papers by this author Kjell Aas MD, Kjell Aas MD Research Institute of Pediatric Allergology, Pulmonology and Environment (FIPALM), Voksentoppen Ullveien 14 0394 Oslo NorwaySearch for more papers by this author First published: September 1994 https://doi.org/10.1111/j.1398-9995.1994.tb00121.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume49, Issue8September 1994Pages 573-575 ReferencesRelatedInformation
Albert Harold Davies
Authors: E. Waldmann
Journal: BMJ (2009)

<h3>Introduction</h3> Activated macrophages may play a critical role in the pathogenesis of acute liver failure (ALF). Serum ferritin (SF) is a circulating marker of macrophage activation, and heavy (H) isoforms of ferritin may have immunostimulatory effects. However, ferritin may be released from necrotic liver, confounding SF interpretation in ALF. The SF/ALT ratio may have prognostic value in non-paracetamol ALF, but has not been examined in patients with paracetamol (POD)-ALF. <h3>Methods</h3> Analysis of SF levels in acute liver injury patients admitted to a tertiary liver center, with western blotting and immunohistochemistry for ferritin isoforms. <h3>Results</h3> Retrospective database analysis revealed elevated admission SF (&gt;300 μg/l) in 109/124 (87.9%) of acute liver injury patients. Extreme SF elevations (&gt;10000 μg/l) were more common in POD (36/71, 50.7%) compared with non-POD patients (5/53, 9.4%, p&lt;0.001). Extremely elevated admission SF was confirmed in a prospective cohort of 47 POD cases (22/47, 46.8%). In both POD cohorts, admission SF was significantly higher in patients who died/were transplanted compared with spontaneous survivors (p=0.001, AUC 0.722 (95% CI 0.614 to 0.831) and in patients who developed hepatic encephalopathy (p=0.038) or the systemic inflammatory response syndrome (SIRS, p=0.008). Hyperferritinaemia correlated with proinflammatory (IL-6, Spearman9s r=0.442, p=0.006; IL-8, r=0.502, p=0.001) and antiinflammatory (IL-10; r=0.349, p=0.030) cytokine release following POD, and with organ dysfunction (SOFA; r=0.529, p&lt;0.001), but not with serum ALT (r=0.113, p=0.227). The ferritin/ALT ratio did not improve prognostic accuracy in PODs (AUC 0.706 (95% CI 0.595 to 0.817). Immunohistochemistry confirmed H and light (L) ferritin isoform expression in both normal liver tissue and explanted tissue from ALF patients. Immunoblotting of serum from POD patients with elevated SF revealed significant amounts of circulating H-ferritin, with no circulating H-ferritin observed in healthy controls. <h3>Conclusion</h3> Extreme elevations of SF are common following POD, and are associated with adverse outcomes. SF is a widely available biomarker that may have prognostic value in patients with POD-ALF and merits further evaluation in larger, prospective studies. The correlation with SIRS, organ failure and cytokinaemia and the observation of circulating H ferritin also suggests that SF may be a mediator of adverse outcome. <h3>Competing interests</h3> None declared.
Impact of SMBG on Control of Diabetes as Measured by HbA1: 3-yr Survey of a Juvenile IDDM Clinic
Authors: Mimi M Belmonte, Alicia Schiffrin, Jackie Dufresne, Samy Suissa, Hy Goldman, Constantin Polychronakos
Journal: Diabetes Care (1988)

Three hundred twelve diabetic children and adolescents were seen in our diabetic clinic and instructed to test their capillary blood glucose (CBG) twice daily and to use an algorithm to adjust their short-acting insulin. Of this group, 219 youngsters had a full 3-yr period of observation. At each clinic visit, blood was obtained for fasting blood glucose and HbA1 and, once a year, cholesterol and triglycerides were also measured. Patient and parent accuracy in measuring CBG was found to be adequate. The changes over time in HbA1 were nondifferential across age and sex, and there was no difference in the level of HbA1 between age and sex groups, the number of tests reported to have been done by the patients, the number of injections of insulin per day, or the serum cholesterol. There was a significant relationship between the HbA1 and the fasting blood glucose (P less than .001) measured by the laboratory as well as with the serum triglyceride (P less than .01). The failure to improve diabetic control, despite measures that would have been expected to do so, was believed to relate more to a lack of compliance than to a flaw in the therapeutic approach. It was interesting to note that the adolescent patients in the study were in no worse control than the younger children in the group. Although better technical skills are available today to manage diabetes, the psychosocial approach to patient motivation requires improvement.
A curious thing
Authors: P. Whelan, C. Kalafatis, J. Oxford, A. Gilbert, R. Lambkin-Williams
Journal: BMJ (2008)

Many of us who have had an influenza infection will know that we aren’t at our sharpest mentally when ill with flu. So, when I and other psychiatry researchers were invited by virology colleagues to test this hypothesis, we jumped at the opportunity. Twenty healthy volunteers were quarantined for 10 days and infected with influenza virus. We administered a number of validated neuropsychological tests assessing various aspects of …
Delivery of dexamethasone, ascorbate, and growth factor (TGF β-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes
Authors: Kun Na, Ji Hyun Park, Sung Won Kim, Bo Kyung Sun, Dae Gyun Woo, Hyung-Min Chung, Keun-Hong Park
Journal: Biomaterials (2006)
Abstract 4304: Malignant melanoma cells with aggressive properties are common and not distinguishable by proposed markers for cancer stem cells
Authors: Lina Prasmickaite, Birgit Engesæter, Nirma Skrbo, Nina K. Oliver, Olav Engebråten, Zhenhe Suo, Steinar Aamdal, Øystein Fodstad, Gunhild M. Mælandsmo
Journal: Cancer Research (2010)

Abstract In malignant melanoma, conflicting results have been reported regarding the presence of exclusive cells with enhanced aggressive properties, so called cancer stem cells (CSC), raising a doubt whether melanoma follows a CSC model and is hierarchically organized. By characterizing melanoma cells from short-term cell cultures, xenografts and patient biopsies, we aim to collect further evidence either to: i) support the existence of distinct CSC-like subpopulations, or ii) strengthen a notion about the common presence of cells demonstrating aggressive behavior and lack of cellular hierarchy in melanoma. By using individual-cell assays, we have shown that a large fraction (up to 60 %) of random single melanoma cells display high clonogenicity and self-renewal i.e. properties associated with tumorigenic potential. In search for a marker for such clonogenic/tumorigenic cells, we found that melanomas often harbor a large distinct subpopulation with elevated activity of Aldehyde Dehydrogenase (ALDH), a proposed marker for CSC-like cells in some hierarchically organized cancers. Interestingly, ALDH activity in melanoma patient biopsies seemed to correlate to the expression of melanoma-associated-antigen, HMW-MAA, which is linked to tumor progression. Furthermore, in vivo ALDH+ melanoma cells could convert to ALDH−, while the opposite conversion was rare, indicating a certain “cellular hierarchy” with respect to the ALDH phenotype. However, comparison of ALDH+ and ALDH− cells revealed that both subpopulations are highly clonogenic, tumorigenic and resistant to drugs proposed for melanoma therapy, DTIC and HGS-ETR2. This suggests that in malignant melanoma, ALDH, likewise earlier investigated “surface markers” of CSCs, does not distinguish cells with enhanced biological aggressiveness. In conclusion, melanoma cells exhibiting properties linked to aggressive phenotype are common and not restricted to subpopulations expressing proposed “CSC markers”, which contradicts the traditional view of CSCs. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4304.
Early fetal growth delay detected by ultrasound marks increased risk of congenital malformation in diabetic pregnancy.
Authors: J F Pedersen, L Molsted-Pedersen
Journal: BMJ (1981)

Ninety-nine insulin-dependent diabetic women with regular menstrual histories were examined by ultrasonic scanning in the seventh to 14th weeks of pregnancy. As judged by the crown-rump length 38 fetuses were smaller than normal. The term early growth delay is suggested for this phenomenon. Nine fetuses had major congenital malformations, and seven of them were smaller than normal in early pregnancy (p less than 0.02). The risk of fetal malformation in diabetic pregnancy increases with the severity of the diabetes. Early fetal growth delay is apparently another risk marker, in this series indicating a risk of 18% (7/38). The combination of severe maternal diabetes (White's classes D and F) and early growth delay yielded a risk of major congenital malformation of 27% (6/22). These observations suggest a common mechanism behind early growth delay and induction of abnormal embryogenesis (and maybe even fetal death). The mechanism is unknown but probably influenced by the quality of regulation of diabetes.
Factor VIII Inhibitor-Reply
Authors: Caroline C. Waddell
Journal: JAMA (1985)

<h3>In Reply.—</h3> The material described by Dr Nour-Eldin is of great interest and certainly warrants further evaluation in patients with factor VIII inhibitors. However, clarification must be made regarding use of the porcine factor VIII concentrate. The patient did achieve a normal factor VIII level following administration of porcine factor VIII (Hyate) and no untoward side effects were attributed to this material.
Improvement of Cystic Fibrosis Airway Mucus Transportability by Recombinant Human DNase Is Related to Changes in Phospholipid Profile
Authors: JEAN-MARIE ZAHM, CLAUDE GALABERT, ALEXANDRA CHAFFIN, JEAN-PIERRE CHAZALETTE, CÉCILE GROSSKOPF, EDITH PUCHELLE
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

The aim of this study was to test whether changes in mucus surface properties by rhDNase treatment could be related to an increased recovery of phospholipids. Purulent sputa from 18 patients with cystic fibrosis (CF) were incubated with either rhDNase (4 μ g/ml) or control excipient. The incubation of mucus samples with rhDNase induced a significant increase (p < 0.002) in the sol phase proportion (33.7 ± 24.0%) compared with that obtained with excipient (12.6 ± 12.4%). Phospholipids were recovered in significantly (p < 0.05) greater amounts from both mucus gel and sol phases after incubation with rhDNase. The phosphatidylglycerol content of mucus sol phase was significantly increased by rhDNase (p < 0.03), as well as the mucus gel phase surface properties and transport by ciliary activity and by cough (p < 0.05). The improvement of mucus gel surface properties and transport capacity by ciliary activity were significantly related to the increased recovery of phosphatidylglycerol (r = − 0.74, p < 0.03 and r = 0.94, p < 0.05, respectively). These results suggest that rhDNase is able to increase the free water content and alter the phospholipid profile of mucus, with a related improvement in CF mucus transportability.
A 51-Year-Old Man With HIV and Cervicodorsal Lipodystrophy (Buffalo Hump)
Authors: Sachin M. Shridharani, Raja Mohan
Journal: JAMA (2013)

A 51-YEAR-OLD AFRICAN AMERICAN MAN WITH A HISTORY OF HUMAN IMMUnodeficiency virus (HIV) and taking abacavir/lamivudine/zidovudine for 1 year presents to the plastic surgery clinic with a chief complaint of cervical lipodystrophy. The patient’s only comorbid condition is hypertension, which is being treated with a -blocker. Physical examination reveals lipodystrophy in the cervicodorsal fat pad (nape of neck) (FIGURE 1). No lipodystrophy is noted in any other anatomical region. Laboratory measures include complete blood cell count, complete metabolic panel, and full endocrine panel; findings are normal. Dexamethasone suppression test results and 24-hour urinary cortisol level are also normal. The patient’s CD4 cell count at the time of presentation is 556 cells/ L, and viral load had reached undetectable levels after 1 year of antiretroviral therapy. What Would You Do Next?
Recombinant Pfs25 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in experimental animals.
Authors: P J Barr, K M Green, H L Gibson, I C Bathurst, I A Quakyi, D C Kaslow
Journal: The Journal of Experimental Medicine (1991)

Pfs25 is a sexual stage antigen of Plasmodium falciparum that is expressed on the surface of zygote and ookinete forms of the parasite. Monoclonal antibodies directed against native Pfs25 can block completely the development of P. falciparum oocysts in the midgut of the mosquito vector. Thus, this 25-kD protein is a potential vaccine candidate for eliciting transmission-blocking immunity in inhabitants of malaria endemic regions. We have synthesized, by secretion from yeast, a polypeptide analogue of Pfs25 that reacts with conformation-dependent monoclonal antibodies, and elicits transmission-blocking antibodies when used to immunize mice and monkeys in conjunction with a muramyl tripeptide adjuvant. Our results suggest the further evaluation of recombinant DNA-derived Pfs25 in transmission-blocking vaccination studies in humans.
High-pressure Salesmanship
Authors: R. E. W. Oliver
Journal: BMJ (1960)

<h3>ABSTRACT</h3> <h3>Background</h3> Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination. Recently, two PADs, PAD2 and PAD4, have been linked to hormone signaling <i>in vitro</i> and the goal of this study was to test for links between PAD2/PAD4 and hormone signaling <i>in vivo.</i> <h3>Methods</h3> Preliminary analysis of <i>Padi2</i> and <i>Padi4</i> single knockout (SKO) mice did not find any overt reproductive defects and we predicted that this was likely due to genetic compensation. To test this hypothesis, we created a <i>Padi2/Padi4</i> double knockout (DKO) mouse model and tested these mice along with wild-type FVB/NJ (WT) and both strains of SKO mice for a range of reproductive defects. <h3>Results</h3> Controlled breeding trials found that male DKO mice appeared to take longer to have their first litter than WT controls. This tendency was maintained when these mice were mated to either DKO and WT females. Additionally, unsexed 2-day old DKO pups and male DKO weanlings both weighed significantly less than their WT counterparts, took significantly longer than WT males to reach puberty, and had consistently lower serum testosterone levels. Furthermore, 90-day old adult DKO males had smaller testes than WT males with increased rates of germ cell apoptosis. <h3>Conclusions</h3> The <i>Padi2/Padi4</i> DKO mouse model provides a new tool for investigating PAD function and outcomes from our studies provide the first <i>in vivo</i> evidence linking PADs with hormone signaling.
Cutis verticis gyrata
Authors: R. Meulenberg, A.P. Oranje, V.D. Vuzevski
Journal: British Journal of Dermatology (1990)

Journal Article Cutis verticis gyrata Get access R. Meulenberg, R. Meulenberg Departments of Dermatology and Venereology, University Hospital, Rotterdam Search for other works by this author on: Oxford Academic Google Scholar A.P. Oranje, A.P. Oranje Departments of Dermatology and Venereology, University Hospital, Rotterdam Search for other works by this author on: Oxford Academic Google Scholar V.D. Vuzevski V.D. Vuzevski Departments of Pathology, University Hospital, Rotterdam Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue 2, 1 August 1990, Pages 260–261, https://doi.org/10.1111/j.1365-2133.1990.tb01861.x Published: 01 August 1990
Irreversible Renal Failure Following Vesicoureteral Reflux
Authors: Harry O. Senekjian, Bobby J. Stinebaugh, Carlos A. Mattioli, Wadi N. Suki
Journal: JAMA (1979)

Antireflux surgery was performed in five patients with vesicoureteral reflux at a time when renal insufficiency was present. Notable proteinuria was present in four of the patients, and a kidney biopsy specimen showed glomerular lesions in one. Despite the eradication of reflux and of infection, all five patients continued to have progressive renal insufficiency culminating in renal failure. Vesicoureteral reflux nephropathy may include a glomerulopathy leading to progressive glomerular sclerosis. Antireflux surgery would not alter this ongoing process and therefore would not halt progressive renal failure.
Cetuximab and Radiotherapy for Head and Neck Cancer
Authors: Marshall R. Posner, Lori J. Wirth
Journal: New England Journal of Medicine (2006)

The treatment of head and neck cancer is complex and difficult, both technically and physically. Tumors in each site in the head and neck (oropharynx, hypopharynx, larynx, and oral cavity) have the same squamous tissue and biologic features, but their clinical presentation and responses to therapy differ according to site. In addition to this level of complexity, there is the inescapable fact that structures of the head and neck control essential, continuously operational functions: speech, swallowing, eating, and breathing. This fact means that the short-term and long-term side effects of treatment can profoundly affect the quality of life.Even so, . . .
The dynamics of language
Authors: Peter W. Culicover, Andrzej Nowak
Journal: Behavioral and Brain Sciences (1999)

To deal with syntactic structure, one needs to go beyond a simple model based on associative structures, and to adopt a dynamical systems perspective, where each phrase and sentence of a language is represented as a trajectory in a syntactic phase space. Neural assemblies could possibly be used to produce dynamics that in principle could handle syntax along these lines.
MECHANISTIC INSIGHTS AND CLINICAL SIGNIFICANCE OF THE ASSOCIATION BETWEEN SEVERE ISOLATED AORTIC STENOSIS, SEVERELY IMPAIRED LEFT VENTRICULAR SYSTOLIC FUNCTION AND HIGH TRANSVALVULAR GRADIENTS
Authors: Eddy Barasch, Florentina Petillo, Dvorah Holtzman, Peter Dong-Yul Rhee, Kanna Posina, Muhammad S. Akhter, Sabrina Sawhney, Simcha Pollack, Nathaniel Reichek
Journal: Journal of the American College of Cardiology (2012)
Biodesign: The Process of Innovating Medical Technologies
Authors: Scott C. Molitor
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discoid lupus erythematosus associated with a primary immunodeficiency syndrome showing features of non-X-linked hyper-IgM syndrome
Authors: None Wolpert, None Webster, None Whittaker
Journal: British Journal of Dermatology (1998)

Hyper‐IgM (HIM) syndrome is a rare primary immunodeficiency disorder. Approximately 120 cases have been described in the literature world‐wide. Features of HIM include low serum IgG, a very low IgA with normal or high IgM levels. Autoimmune phenomena are recognized associations but connective tissue disorders have so far not been described in HIM patients. We report the case of a 19‐year‐old Indian woman with an immunodeficiency syndrome characteristic of non‐X‐linked HIM who developed discoid lupus erythematosus. Anti‐double‐stranded DNA antibodies were negative. Antibodies to extractable nuclear antigens were positive for Ro and nRNP, with evidence that they were of both IgG and IgM class. Treatment with hydroxychloroquine and topical steroids was successful.
Perphenazine Therapy Among Outpatients
Authors: W. L. JAQUITH, H. R. NAIL, B. S. SMITH, M. R. TAYLOR
Journal: American Journal of Psychiatry (1967)

During its seven years of use at Mississippi State Hospital, perphenazine has been very effective in treating acutely ill patients and as maintenance therapy in nonhospitalized patients. No attempt was made to compare perphenazine with other phenothiazines. It is our impression from the results obtained that perphenazine significantly reduces rehospitalization and total hospital time and effects a significantly better home adjustment.
Calcium blockers for heart disease: two approved, more to come
Authors: J. Kangilaski
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal