tbuckley/cabot-search huggingface dataset:
Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens
Authors: Lucienne M. Ide, Bagirath Gangadharan, Kuang-Yueh Chiang, Christopher B. Doering, H. Trent Spencer
Journal: Blood (2007)

Abstract Insufficient expression of factor VIII (fVIII) is a major hurdle in the development of successful nucleic acid treatments for hemophilia. However, we recently showed that under myeloablative and reduced-intensity total body irradiation (TBI) conditioning, transplantation of hematopoietic stem cells (HSCs) transduced with recombinant retroviruses containing B domain–deleted porcine fVIII (BDDpfVIII) sequences provides curative fVIII levels in a hemophilia A mouse model. In the current study, we tested BDDpfVIII activity after nonmyeloablative conditioning with busulfan, cyclophosphamide, or fludarabine and immunosuppressive agents CTLA4-Ig + anti-CD40L or anti-(murine)thymocyte serum (ATS). ATS is similar in action to anti-(human)thymocyte globulin (ATG), which is used clinically with busulfan in bone marrow transplantations to increase donor cell engraftment. Mice conditioned with busulfan + ATS and that received a transplant of BDDpfVIII-transduced stem-cell antigen 1-positive cells exhibited moderate levels of donor cell chimerism (between 20% and 60%) and achieved sustained fVIII levels more than 1 U/mL. Similar results were observed in mice preimmunized with human fVIII and conditioned with 5 Gy TBI + ATS or busulfan + ATS. These data demonstrate that it is possible to achieve sufficient fVIII expression after transplantation of BDDpfVIII-transduced HSCs following low-toxicity pretransplantation conditioning with targeted immunosuppression, potentially even in the context of preexisting inhibitors.
Pseudo-Vascular Tumor in a Renal Flow Study
Authors: ABDELHAMID H. ELGAZZAR, MARIANO FERNANDEZ-ULLOA, GERALD TYRONE POWERS
Journal: Clinical Nuclear Medicine (1985)

A case in which, for the first time, the superior mesenteric artery caused an appearance mimicking vascular tumor on a kidney radionuclide angiogram (RNA) obtained posteriorly, is reported. A subsequent contrast arteriogram showed that the superior mesenteric artery caused that appearance and confusion with possible vascular tumor on RNA. No similar cases with mesenteric blush simulating vascular tumor have been found in the literature. Mesenteric blushes on RNAs obtained posteriorly have been described only in cases of kidney agenesis and post-nephrectomy. This pattern should be kept in mind when interpreting RNAs to avoid subjecting patients to invasive diagnostic procedures.
Air in the bones: multifocal anaerobic osteomyelitis associated with oat cell carcinoma.
Authors: J Philippe, E Sheybani, B Hirschel, B Ody
Journal: BMJ (1985)

Air in the bones: multifocal anaerobic osteomyelitis associated with oat cell carcinoma Under 2",, of cases of osteomyelitis are due to anaerobes.'We report a case of multifocal anaerobic osteomyelitis complicating widespread bone metastases from an oat cell carcinoma of the lung. Case reportA 60 year old white man was admitted with low back pain, 10 kg weight loss, and bilateral leg oedema.He was a heavy smoker and drinker.He was afebrile with signs of chronic alcoholism and bilateral leg oedema.Oral hygiene was poor.His liver was firm and enlarged.His lumbar vertebrae and pelvic bones were painful on percussion.White cell count was 22-3x 109/ (68°,0 segmented).A chest x ray film showed a 2 cm nodule.
Quality of Life in Patients with Limited Small-Cell Carcinoma of the Lung Receiving Chemotherapy with or without Radiation Therapy, for Cancer and Leukemia Group B
Authors: Tim A. Ahles, Peter M. Silberfarb, Amy Chen Rundle, Jimmie C. Holland, Alice B. Kornblith, George P. Canellos, Mark R. Green, Michael C. Perry
Journal: Psychotherapy and Psychosomatics (1994)

Quality of life was assessed in 57 patients with limited small-cell carcinoma of the lung utilizing psychological scales that measured mood, functional status, and cognitive impairment. These patients received chemotherapy with or without radiotherapy to the primary tumor. All patients received prophylactic cranial radiation. Patients who received the combination of chemotherapy and radiotherapy to both the primary tumor and CNS had an increase in overall survival. However, because of the increased toxicity experienced by these patients, a decrease in quality of life was documented by measures of psychological distress when compared to patients receiving chemotherapy alone. The findings support the importance of utilizing quality of life measures in addition to measures of physical toxicity so that patients can make an informed choice regarding treatment options.
STUDIES ON HERPETIC INFECTION IN MICE
Authors: Charles A. Evans, Howard B. Slavin, George Packer Berry
Journal: The Journal of Experimental Medicine (1950)

1. The severity of herpetic infection, of mice varied according to the site of inoculation, decreasing in the following order: cornea, skin of abdomen, pad of hind foot, tail. 2. The preliminary treatment of the foot pad or tail with methylcholanthrene increased the susceptibility to herpetic infection to a limited extent. 3. Two-week-old mice showed a much greater susceptibility to herpes virus inoculated on the tail or on the pad of the hind foot than did adult mice. 4. The HF strain of herpes virus, after more than 125 serial brain-to-brain passages in mice, possessed high virulence for cutaneous tissues of mice and showed no important differences in this respect from a recently isolated strain (Klee) of herpes virus.
A Mitochondrial Ancestry of the Hydrogenosomes of Nyctotherus ovalis
Authors: Angela H. A. M. van Hoek, Anna S. Akhmanova, Martijn A. Huynen, Johannes H. P. Hackstein
Journal: Molecular Biology and Evolution (2000)

Hydrogenosomes are membrane-bounded organelles about 1 mm in size that, like mitochondria, produce ATP (Muller 1993). They compartmentalize terminal steps of anaerobic energy metabolism but, unlike mitochondria, hydrogenosomes cannot use oxygen as an electron acceptor; they reduce protons to molecular hydrogen (Embley and Martin 1998; Martin and Muller 1998; Muller 1998). Hydrogenosomes have been found only in anaerobic protists and fungi, for example, the parabasalian flagellate Trichomonas vaginalis, the amoeboflagellate Psalteriomonas lanterna, the anaerobic ciliate Nyctotherus ovalis, and the anaerobic chytridiomycete fungi Neocallimastix frontalis and Piromyces sp. (Muller 1993). A wealth of biochemical and molecular genetic evidence argues that hydrogenosomes share a common ancestor with mitochondria (Biagini, Finlay, and Lloyd 1997; Embley, Horner, and Hirt 1997; Sogin 1997; Martin and Muller 1998). However, since—with one notable exception—all hydrogenosomes studied so far lack a genome, a direct proof remained difficult. Recently, we provided evidence for the presence of a genome in the hydrogenosomes of the gut-dwelling anaerobic ciliate N. ovalis (Akhmanova et al. 1998). Immunogold labeling allowed colocalization of hydrogenase and doublestranded DNA in the hydrogenosomes of the ciliate. These organelles look like mitochondria, but they are surrounded by endosymbiotic methanogenic archaea that indicate (1) anoxic conditions in the immediate vicinity of the mitochondria-like organelles and (2) the presence of intracellular hydrogen (cf. Fenchel and Finlay 1995). Using reverse transcription–polymerase chain reaction (RT-PCR) and PCR approaches, we succeeded in isolating and sequencing a complete SSU rRNA that is abundantly expressed in the ciliates (Akhmanova et al. 1998). This putative hydrogenosomal SSU rRNA (accession number Y16670) proved to be greatly different with regard to nucleotide sequence and the lengths of variable regions from the respective SSU rRNA genes of the ciliate and its methanogenic endosymbionts (van Hoek et al. 1998, 1999, 2000). Notwithstanding a high
Oestrogen replacement therapy after hysterectomy.
Authors: A. Clarke, N. Black, P. Rowe
Journal: BMJ (1992)

although opioids have their own clinically relevant adverse effects.'There is much current interest in the use of non-steroidal anti-inflammatory drugs as adjuvant agents with other analgesics after surgery.Several studies have shown that combining non-steroidal anti-inflammatory drugs with opioids provides superior analgesia with less total opioid required and possibly a reduction in side effects mediated by opioids, such as respiratorv depression and sedation.Furthermore, there is good reason to believe that giving non-steroidal anti-inflammatory drugs before surgery may result in a pre-emptive analgesic effect with a subsequent reduction in postoperative analgesic requirements and the associated adverse effects.'The results of controlled trials to substantiate this effect in humans are awaited.We suggest, therefore, that until there is stronger evidence for clinically significant impairment of wound healing, non- steroidal anti-inflammatory drugs should continue to be used for surgical patients without other contraindications as they have a useful role in the management of postoperative pain.
803 EFFECTS OF SYSTEMATIC NURSE-PROVIDED THERAPEUTIC EDUCATION ON ADHERENCE AND EFFICIENCY OF PEG-INTERFERON-ALPHA2A (PEGASYS®)-RIBAVIRIN TREATMENT IN CHRONIC HEPATITIS C (PEGOBS PROTOCOL)
Authors: D. Larrey, A. Salse, G.P. Pageaux, N. Funakoshi, D. Ribard, O. Boutet, V. Hyrailles, B. Niang, E. Vaucher, J.P. Arpurt, A.J. Rémy, S. Dahmouni, N. Kharlova, J.P. Daurès
Journal: Journal of Hepatology (2008)
The Cincinnati Radiation Tests—Reply
Authors: Kenneth L. Mossman
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Actinomycosis in the North-east of Scotland
Authors: I. A. Porter
Journal: BMJ (1951)

JOURNA -~~~~~~~~~~~EIAThe increased rise in the rectal temperature could not be attributed to the diminished sweating, as there was always more sweat produced than could be evaporated, and in Thomson's experiments considerably greater reduction of sweat, after ultra-violet irradiation, did not affect heat tolerance.A systemic disorder must therefore be postulated, which would also account for the lassitude and debility.The subject was, in fact, a mild but typical case of Ladell, Waterlow, and Hudson's Type II heat exhaustion.To adopt Selye's (1950) terminology, Type II exhaustion might be called, as a working hypothesis, a " disease of adaptation."To some extent this con- cept is supported by accumulating evidence that the adrenal cortex may be involved in the control of sweating (Ladell, 1945b; Conn and Louis, 1950); on this theory, prickly heat would be the stress which, added to the several already imposed by a tropical climate, would rapidly lead to what Selye calls the " exhaustion stage," so that even after apparent recovery the heat tolerance remains markedly diminished.A somewhat similar hypothesis has been advanced elsewhere (Ladell, 1948b), but positive evidence for it has not yet been obtained.
Herpesvirus hominis Infection in Patients with Myeloproliferative and Lymphoproliferative Disorders
Authors: D. L. Aston, A. Cohen, M. A. Spindler
Journal: BMJ (1972)

Infection with Herpesvirus hominis, often associated with oral ulceration, was found to be more frequent in patients with myeloproliferative and lymphoproliferative disorders than in normal populations or patients with other diseases. This increased frequency was not associated with any deficiency of the humoral antibody response, suggesting a possible impairment of cell-mediated immunity. The otherwise untreatable oral lesions appeared to respond effectively to local irradiation.
TCTAP A-034 Is Final Kissing Ballooning Mandatory in the Treatment of Distal Left Main Disease Treated by Simple Cross Over Stenting?
Authors: Seung-Jung Park, Hee-soon Park, Se Hun Kang, Min Su Kim, Byeong Joo Bae, Sang Soo Cheon, Jae Hyung Roh, Pil Hyung Lee, Mineok Chang, Hyun Woo Park, Sung Han Yoon, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park
Journal: Journal of the American College of Cardiology (2015)
P977 UNRESECTABLE HEPATOCELLULAR CARCINOMA (HCC) TREATED BY TRANSARTERIAL CHEMOEMBOLIZATION (TACE): AFTER TWO SESSIONS, ART OR ABCR SCORES TO GUIDE THE DECISION MAKING PROCESS?
Authors: X. Adhoute, G. Penaranda, J.-L. Raoul, P. Castellani, H. Perrier, O. Monnet, C. Muller, O. Bayle, M. Campanile, G. Lefolgoc, S. Benaly, V. Oules, M. Bourliere
Journal: Journal of Hepatology (2014)
Consultation-Liaison Services in the General Hospitals
Authors: Z.J. Lipowski
Journal: Psychotherapy and Psychosomatics (1972)

Consultation-liaison psychiatry is a rapidly developing area of clinical psychiatry. It refers to all clinical, teaching and research activities of a special team of psychiatrists in all the non-psychiatric sections of a general hospital. The development of this subspecialty within psychiatry has paralleled the shift of psychiatric services from large mental hospitals (sometimes called 'human silos') to the general hospitals. This has strengthened the ties between medicine and psychiatry, and allowed teaching of psychosomatic medicine in its new broad sense.
WATER PRESSURE CLEANSING FOR INSTRUMENTS OF SMALL CALIBER
Authors: Harold L. Morris
Journal: JAMA (1925)

To simplify the cleaning of ureteral catheters, instillators, hypodermic needles of all types, spinal puncture needles and trocars, from the accumulation of blood cells, pus and epithelium and any other debris that may be present, a new attachment for the water faucet is adaptable. It may be used with either the screw-type or plain faucet. Sufficient hydrostatic pressure can be obtained and regulated, by means of adapters to the tips, to clean adequately any small caliber instrument.
Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet.
Authors: A I Fyfe, J H Qiao, A J Lusis
Journal: Journal of Clinical Investigation (1994)

Inbred strain C57BL/6J mice develop typical atherosclerotic fatty streaks in the aorta after 15 wk on a high fat, high cholesterol diet. To investigate the effects of the immune system on the development of fatty streaks in this model, C57BL/6J mice with a normal immune system were compared with C57BL/6J mice carrying mutations resulting in various immune deficiencies. These included mice with severe combined immune deficiency, athymic "nude" mice, class I MHC deficient mice, and class II MHC deficient mice. Despite similar lipoprotein profiles, lesion development in the immune compromised strains was similar to or increased compared with normal C57BL/6J mice. Class I MHC deficient mice demonstrated a threefold increase in lesion area (22,961 +/- 6,653 vs 8,868 +/- 1,817 microns2, P = 0.01). Immunohistochemical analysis of lesions showed characteristic features of atherosclerosis with vascular cell adhesion molecule-1 expression, immunoglobulin deposition, monocyte infiltration, and smooth muscle cell proliferation. These data indicate that the classical immune system, while not essential for atherosclerotic fatty streak development, may act to suppress the development of lesions.
Long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats
Authors: Can Li, Chul Woo Yang, Cheol Whee Park, Hee Jong Ahn, Wan Young Kim, Kun Ho Yoon, Sun Hee Suh, Sun Woo Lim, Jung Ho Cha, Yong Soo Kim, Jin Kim, Yoon Sik Chang, Byung Kee Bang
Journal: Kidney International (2003)
Anesthesia in Children — Limitations of the Data on Neurotoxicity
Authors: Nancy L. Glass, Shobha Malviya
Journal: New England Journal of Medicine (2011)

To the Editor: We share the concerns that Rappaport et al. express in their Perspective article in this issue of the Journal regarding possible relationships between anesthetic agents and neurologic damage in young children. However, clinicians are challenged with extrapolating neurodevelopmental stages and behavioral correlates from animal models to human infants. Studies in animals reveal worrisome neuronal apoptosis after anesthesia, raising questions about whether pediatric anesthesiologists should change their practice and what they should tell parents. Studies in animals involve prolonged exposure to anesthetics in high doses with variable monitoring and no surgical stress. Furthermore, translating stages of brain development . . .
Seroepidemiologic Studies of Infectious Mononucleosis with Eb Virus
Authors: Alfred S. Evans, James C. Niederman, Robert W. McCollum
Journal: New England Journal of Medicine (1968)

Certain epidemiologic features of infectious mononucleosis are indicated by antibody patterns to the EB or herpes-like virus of Burkitt lymphoma. The absence of antibody correlated well with susceptibility: of 268 entering college students whose serums lacked EBV antibody, infectious mononucleosis developed in 15 per cent; in 94 whose serums already contained antibody, none had clinical disease. EBV antibody also correlated well with heterophil antibody; EBV antibody was present in the serums of all 135 patients who had heterophil-antibody-positive infectious mononucleosis and also in six with clinically and hematologically typical cases whose serums were persistently heterophil-antibody negative, suggesting that EB virus may be associated with both forms of illness. In a third group of patients clinical features resembled infectious mononucleosis, but the serums contained neither heterophil nor EBV antibodies. At present, EB virus is strongly implicated as a cause of infectious mononucleosis.
TCT-792 Treatment and Clinical Outcomes of Transcatheter Heart Valve Thrombosis: Multi-center Registry
Authors: Toru Naganuma, Azeem Latib, Ariel Finkelstein, Victor M. Legrand, Marco Barbanti, Jean-Claude Laborde, Linda Cota, Eugenio Stabile, Suàrez De Lezo. Javier, Charis Costopoulos, Francesco Maisano, Antonio Colombo
Journal: Journal of the American College of Cardiology (2013)
Doctor in Netherlands is jailed for three years for "medically irresponsible" treatment of patients
Authors: T. Sheldon
Journal: BMJ (2014)

In one of the longest criminal investigations in Dutch medical history a former neurologist, Ernst Jansen Steur, has been jailed for three years for harming his patients. This was the first case in the Netherlands of a doctor receiving an unconditional prison sentence for medical malpractice.

From 2009 to 2012 the public prosecution service investigated 40 of Steur’s former patients. Unknown to the prosecutors, Steur was at that time working as a doctor in Germany after being sacked by …
Abstract B83: Targeting tumor-infiltrating macrophages decreases pancreatic tumor-initiating cells and improves chemotherapeutic responses by relieving immune suppression.
Authors: Jonathan B. Mitchem, Donal J. Brennan, Dominic E. Sanford, Brett L. Knolhoff, Yu Zhu, Belt Brian, Andrea Wang-Gillam, Peter Goedegebuure, David C. Linehan, David G. DeNardo
Journal: Cancer Research (2013)

Abstract Tumor-infiltrating immune cells can promote chemoresistance and metastatic spread in aggressive tumors. Consequently, the type and quality of immune responses present in the neoplastic stroma are highly predictive of patient outcome in several cancer types. In addition to host immune responses, intrinsic tumor cell activities that mimic stem cell properties have been linked to chemoresistance, metastatic dissemination, and the induction of immune suppression. Far from being a static cell population, the presence of cancer stem cells appears to be controlled by highly dynamic processes that are dependent on cues from the tumor stroma. However, the impact that immune responses have on the differentiation or expansion of tumor stem cells is not well understood. In this study, we demonstrate that targeting tumor-infiltrating macrophages and inflammatory monocytes by either inhibition of colony stimulating factor-1 receptor (CSF1R) or chemokine (C-C motif) receptor 2 (CCR2) decreases the number of tumor-initiating cells in pancreatic tumors. Targeting CCR2 or CSF1R improves chemotherapeutic efficacy, inhibits metastasis, and increases antitumor T-cell responses. We also found that tumor-educated macrophages could directly enhance the tumor-initiating capacity of pancreatic tumor cells through the activation of signal transducer and activator of transcription 3 (STAT3). In turn, these STAT3-activated tumor-initiating cells facilitate macrophage-mediated suppression of CD8+ T lymphocytes. These data suggest that targeting tumor-infiltrating macrophages is an effective strategy for overcoming therapeutic resistance due to the presence of tumor-initiating cells. Citation Format: Jonathan B. Mitchem, Donal J. Brennan, Dominic E. Sanford, Brett L. Knolhoff, Yu Zhu, Belt Brian, Andrea Wang-Gillam, Peter Goedegebuure, David C. Linehan, David G. DeNardo. Targeting tumor-infiltrating macrophages decreases pancreatic tumor-initiating cells and improves chemotherapeutic responses by relieving immune suppression. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr B83.
Review: Low-molecular-weight heparin reduces risk for venous thromboembolism in adults with leg immobilization
Authors: Benilde Cosmi
Journal: Annals of Internal Medicine (2009)

Source Citation Testroote M, Stigter W, de Visser DC, Janzing H. Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization. Cochrane Database Syst Rev. 2008;4:CD006681. 18843725
A piece of my mind: painful prescriptions
Authors: C. S. Hill
Journal: JAMA (1987)

The author illustrates by example the myths and misconceptions that still exist among physicians concerning the proper use of narcotics to alleviate the chronic, intractable pain of advanced cancer. He maintains that the patient whose physical and psychological suffering is relieved by regularly scheduled narcotic analgesics is not an addict. Hill urges physicians to reeducate themselves about pain control and not to allow a concern for potential abuse to prejudice professional judgment and the duty to relieve pain and suffering.