tbuckley/cabot-search huggingface dataset:
Argyrin A Reveals a Critical Role for the Tumor Suppressor Protein p27kip1 in Mediating Antitumor Activities in Response to Proteasome Inhibition
Authors: Irina Nickeleit, Steffen Zender, Florenz Sasse, Robert Geffers, Gudrun Brandes, Inga Sörensen, Heinrich Steinmetz, Stefan Kubicka, Teresa Carlomagno, Dirk Menche, Ines Gütgemann, Jan Buer, Achim Gossler, Michael P. Manns, Markus Kalesse, Ronald Frank, Nisar P. Malek
Journal: Cancer Cell (2008)
The Journals of Willie A. Lindsay: An Ordinary Nineteenth-Century Physician's Surgical Cases
Authors: Ira M. Rutkow
Journal: JAMA (1990)

As Katherine McDonell, the editor, states in her introduction, "William A. Lindsay (1795-1876) was an ordinary midwestern physician." Unfortunately, as ordinary as he was, his surgical journals are even more banal. Since Lindsay did not merit a listing in Holloway's<i>Medical Obituaries: American Physicians' Biographical Notices in Selected Medical Journals Before 1907</i>, I was immediately suspect of his impact on midwestern medicine. Not only were his contributions negligible, but it seems Lindsay was every bit a scoundrel and hawker of secret tonics and patent medicines. Lindsay began writing his four journals (the second is missing and presumed lost) in 1836 and ceased in 1855. However, all of the described cases, except two, took place from 1822 through 1841. In almost every instance, Lindsay reconstructed the operation and the events surrounding it. Whether his memory was faithful to the actual occurrences will forever remain unknown. The vast majority of cases refer
CHRONIC SCLEROSING OSTEITIS
Authors: MELVIN S. HENDERSON
Journal: JAMA (1924)

Localized proliferative chronic nonsuppurative sclerosing osteitis is revealed in the roentgenogram by a spindle-shaped thickening of the bone. The medullary cavity is reduced in size, and the bone is increased in density. The pain is a deep aching, usually worse at night and on exertion. The lower extremity is more often involved; there is local swelling, local heat, and often tenderness on deep pressure. The condition is sufficiently rare to confuse even surgeons of wide experience. The literature on the subject is not abundant. Gosselin,<sup>1</sup>in 1868, gave a good description of the condition. Cheyne,<sup>2</sup>in 1890, described a case of osteitis in the radius in which, at operation, a sequestrum was removed without a trace of pus being encountered. Kluppel,<sup>1</sup>in 1879, recorded the condition in the femur of a boy, aged 12 years. Garré's<sup>3</sup>classical description appeared in 1893, after which the condition was
Amlodipine and endothelial nitric oxide synthase activity
Authors: R Tabrizchi
Journal: Cardiovascular Research (2003)

Time for primary review 2 days.

See article by Lenasi et al. [1] (pages 844–853) in this issue. 

In an interesting and well crafted paper in this issue Lenasi et al. [1] have provided novel and exciting evidence on the ability of the 1,4-dihydropyridine Ca2+ channel antagonists, amlodipine and nifedipine, to generate nitric oxide (NO) and in doing so produce relaxation in the vasculature.

Admittedly, organic Ca2+ channel antagonists produce vasorelaxation predominantly by inhibiting the influx of Ca2+ into smooth muscle cells via the so-called voltage-gated Ca2+ channels [2]. However, there is empirical clinical data which implies that, in part, the cardiovascular protective actions of some Ca2+ channel antagonists cannot be readily explained purely on the basis of the inhibition of voltage-gated Ca2+ channels. For example, it has been reported that in the Prospective Randomized Amlodipine Survival Evaluation Study Group (PRAISE) trial, that amlodipine produced substantial beneficial effects in the group of patients with dilated cardiomyopathy, and that there was a 31% ( P =0.04) reduction in combined fatal and nonfatal events, as well as, a decrease in the risk of death by 46% ( P <0.001) in patients with nonischaemic cardiomyopathy [3]. In addition, data from Prospective Randomized Evaluation of the Vascular Effects of Nordics Trial (PREVENT) has revealed that while treatment with amlodipine did not produce demonstrable effects on angiograghic progression of coronary atherosclerosis, it did result in fewer hospitalizations for unstable angina and revascularization [4]. Moreover, in the same trial it was also revealed that treatment with amlodipine slowed the progression of carotid artery atherosclerosis [4]. Taken together, these findings among others have propelled the view that perhaps other mechanisms may, … 

*Tel.: +1-709-777-6864; fax: +1-709-777-7010.
Quantitative coronary angiography: measurement of the "critical" stenosis in patients with unstable angina and single-vessel disease without collaterals.
Authors: M M McMahon, B G Brown, R Cukingnan, E L Rolett, E Bolson, M Frimer, H T Dodge
Journal: Circulation (1979)

Quantitative angiographic assessment of proximal coronary artery stenosis was performed in 15 patients with consecutive presentations in two categories defined by clinical and angiographic criteria. Group 1 consisted of 10 patients who had new onset of refractory rest angina and ischemic ST-T changes, but no infarction, single-vessel coronary disease without collateralization, and normal left ventricular (LV) angiograms. Group 2 consisted of five patients who were similar to patients in group 1, but had subendocardial infarction (SEI). Quantitative coronary arteriography, using paired perpendicular angiographic views and digital computation, yielded statistically different lesion dimensions and hemodynamic predictions for the two groups. Minimum stenosis diameters were 0.88 +/- 0.14 (SD) and 0.64 +/- 0.08 mm, respectively, for groups 1 and 2. This corresponded to 72% and 78% diameter reduction and 92% and 95% cross-sectional area reduction for the two groups. These small dimensional differences among lesions in the two groups resulted in large differences in their hemodynamic impact as predicted from classic fluid mechanics theory. We conclude that there are characteristic lesion dimensions for the isolated "critical" stenosis in these selected patients with rest angina. Further small increases in lesions severity result in SEI. Certain practical applications and limitations of these observations are discussed.
Correct technique is important in cardioversion of atrial fibrillation
Authors: A. K B Slade, S M. Sopher, A J. Camm, D. E Ward
Journal: BMJ (1996)

Epley's procedure should be used to treat benign positional vertigo EDITOR,-In response to our review on the'.treatment of benign positional vertigo' Graeme M Weiner advocates Cawthorne-Cooksey exercises as the superior choice for this condition.2We are aware that this reflects widespread practice in Brit- ain, but the published evidence justifying it is weak.Cawthorne-Cooksey exercises were devised to promote central compensation of stable unilateral vestibular deficits, and they serve this purpose well.Only one study, however, has evaluated the efficacy of such exercises for benign positional vertigo; it found that 32% of patients were cured after one week.3This compares unfavourably with the 60-80% rate of immediate success after just one application of Epley's procedure as shown in several open studies cited in our review.The efficacy of this technique, which aims to clear the posterior semicircular canal ofmobile particles, has been substantiated further by two recent studies.4'Patients appreciate the physician's support through a quick and effective manoeuvre as an alternative to repeated self inflicted attacks of the condition as occur with Cawthorne-Cooksey exercises.The 20% of patients who experience frequent recur- rences can be taught an adapted version of Epley's procedure for self treatment at home.We would invite Weiner to try Epley's manoeuvre himself because it was the grateful response of patients that ultimately defeated our initial scepticism.
EXTENT OF ATHEROSCLEROSIS IRRESPECTIVE OF STENOSIS IS A BETTER OUTCOME PREDICTOR THAN NUMBER OF OBSTRUCTED VESSELS IN INVASIVE CORONARY ANGIOGRAPHY
Authors: Martin Hadamitzky, Simone Keilhacker, Adnan Kastrati, Albert Schömig, Deutsches Herzzentrum
Journal: Journal of the American College of Cardiology (2011)
My Calculus Teacher Makes a House Call-for Lou Ulery
Authors: John L. Wright
Journal: Annals of Internal Medicine (1998)

Ad Libitum1 August 1998My Calculus Teacher Makes a House Call-for Lou UleryJohn L. Wright, MDJohn L. Wright, MDEdmonds, WA 98020Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-3-199808010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail standing before ... Author, Article, and Disclosure InformationAffiliations: Edmonds, WA 98020Corresponding Author: John L. Wright, MD, PO Box 761, Edmonds, WA 98020. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1998Volume 129, Issue 3Page: 258KeywordsKneesScars ePublished: 15 August 2000 Issue Published: 1 August 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Thrombocytosis in Patients With Lung Cancer
Authors: Stephen E. Silvis
Journal: JAMA (1970)

The records of 190 patients with a proved diagnosis of lung cancer showed that 60% of the 153 patients in whom platelet counts were performed had thrombocytosis, whereas only 2.6% had thrombocytopenia. Little correlation was found between platelet counts and hemoglobin concentrations. Thromboembolism occurred in 8.9% of the patients during their hospital stay, these patients had slightly higher average hemoglobin values compared with those patients without this complication. The average platelet counts were essentially the same in both groups.
A CASE OF CHRONIC GLANDERS, WITH RECOVERY.Read before the Section on Surgery and Anatomy at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: BAYARD HOLMES
Journal: JAMA (1893)

ABSTRACT. This paper begins by showing that the bacillus maleus is the prime etiological factor in glanders; That glanders is allied to the chronic infectious diseases, and its normal host probably one of the domestic animals; That the bacillus is an obligate parasite of its host; That it resembles morphologically the other bacterial parasites that produce chronic infectious diseases in man, especially tuberculosis and leprosy; That the occurrence of glanders in man is rare, and that it presents itself in two forms; one acute and rapidly fatal, terminating as a rule inside of two or three months at the farthest; the other chronic, from which the patient may recover after one, two, four or five years of disease; That the occurrence of glanders is usually due to the association of man with domestic animals, or persons suffering from the disease. CASE. The case which I have to present was referred
Electrocardiographic and Plasma Potassium Responses Elicited on Cooling the Chest Wall of Man
Authors: BENJAMIN KAMINER, RALPH E. BERNSTEIN
Journal: Circulation (1957)

The application of ice to the anterior chest wall in human subjects resulted in retardation of repolarization of the anterior myocardium and was accompanied by a decrease in the plasma potassium. These phenomena were tentatively related to the effects of local cooling of the myocardium.
Hypnosis: Physiological, Pharmacological Reality
Authors: GEORGE A. ULETT, SEVKET AKPINAR, TURAN M. ITIL
Journal: American Journal of Psychiatry (1972)

Normal volunteers were successfully hypnotized using a videotape induction technique. EEG measurements were made before trance induction, during induction, and during objective testing of the depth of hypnosis. Electronic analysis of EEG records revealed a significant correlation between hypnotizability and certain EEG patterns, including the presence of very fast activity. During the trance-induction and trance-testing periods, good hypnotic subjects showed a significant decrease in slow activity and an increase in alpha and beta waves. In later experiments, such psychotropic drugs as LSD-25 and dextroamphetamine were found to alter hypnotizability.
Nanoscale Topography and Chemistry Affect Embryonic Stem Cell Self‐Renewal and Early Differentiation
Authors: Vanessa L. S. LaPointe, Ana Tiago Fernandes, Nia C. Bell, Francesco Stellacci, Molly M. Stevens
Journal: Advanced Healthcare Materials (2013)

Adherent cells respond to a wide range of substrate cues, including chemistry, topography, hydrophobicity, and surface energy. The cell-substrate interface is therefore an important design parameter in regenerative medicine and tissue engineering applications, where substrate cues are used to influence cell behavior. Thin films comprising 4.5 nm (average diameter) gold nanoparticles coated with a mixture of two alkanethiols can confer hemispherical topography and specific chemistry to bulk substrates. The behavior of murine embryonic stem cells (ESCs) on the thin films can then be compared with their behavior on self-assembled monolayers of the same alkanethiols on vapor-deposited gold, which lack the topographical features. Cells cultured both with and without differentiation inhibitors are characterized by immunofluorescence for Oct4 and qPCR for Fgf5, Foxa2, Nanog, Pou5f1, and Sox2. Nanoscale chemistry and topography are found to influence stem cell differentiation, particularly the early differentiation markers, Fgf5 and Foxa2. Nanoscale topography also affects Oct4 localization, whereas the chemical composition of the substrate does not have an effect. It is demonstrated for the first time that ESCs can sense topographical features established by 4.5 nm particles, and these findings suggest that nanoscale chemistry and topography can act synergistically to influence stem cell differentiation. This study furthers the understanding of the effects of these substrate properties, improving our ability to design materials to control stem cell fate.
Genital inflammatory lymphoedema: peculiar microvascular long-distance metastasis of gastric carcinoma
Authors: B. Hegemann, P. Helmbold, W.cH. Marsch
Journal: British Journal of Dermatology (2001)

Journal Article Genital inflammatory lymphoedema: peculiar microvascular long‐distance metastasis of gastric carcinoma Get access B. Hegemann, B. Hegemann Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin Luther‐Universität Halle‐Wittenberg, Ernst‐Kromayer‐Straße 5–8, 06097 Halle/Saale, GermanyE‐mail: bernd.hegemann@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar P. Helmbold, P. Helmbold Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin Luther‐Universität Halle‐Wittenberg, Ernst‐Kromayer‐Straße 5–8, 06097 Halle/Saale, GermanyE‐mail: bernd.hegemann@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar W.cH. Marsch W.cH. Marsch Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin Luther‐Universität Halle‐Wittenberg, Ernst‐Kromayer‐Straße 5–8, 06097 Halle/Saale, GermanyE‐mail: bernd.hegemann@medizin.uni‐halle.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 2, 1 February 2001, Pages 419–420, https://doi.org/10.1046/j.1365-2133.2001.04042.x Published: 01 February 2001
The accumulated evidence on lung cancer and environmental tobacco smoke
Authors: A K Hackshaw, M R Law, N J Wald
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To estimate the risk of lung cancer in lifelong non-smokers exposed to environmental tobacco smoke. <b>Design:</b> Analysis of 37 published epidemiological studies of the risk of lung cancer (4626 cases) in non-smokers who did and did not live with a smoker. The risk estimate was compared with that from linear extrapolation of the risk in smokers using seven studies of biochemical markers of tobacco smoke intake. <b>Main outcome measure:</b> Relative risk of lung cancer in lifelong non-smokers according to whether the spouse currently smoked or had never smoked. <b>Results:</b> The excess risk of lung cancer was 24% (95% confidence interval 13% to 36%) in non-smokers who lived with a smoker (P&lt;0.001). Adjustment for the effects of bias (positive and negative) and dietary confounding had little overall effect; the adjusted excess risk was 26% (7% to 47%). The dose-response relation of the risk of lung cancer with both the number of cigarettes smoked by the spouse and the duration of exposure was significant. The excess risk derived by linear extrapolation from that in smokers was 19%, similar to the direct estimate of 26%. <b>Conclusion:</b> The epidemiological and biochemical evidence on exposure to environmental tobacco smoke, with the supporting evidence of tobacco specific carcinogens in the blood and urine of non-smokers exposed to environmental tobacco smoke, provides compelling confirmation that breathing other people9s tobacco smoke is a cause of lung cancer. <h3>Key messages</h3> A woman who has never smoked has an estimated 24% greater risk of lung cancer if she lives with a smoker Neither bias nor confounding accounted for the association There is a dose-response relation between a non-smoker9s risk of lung cancer and the number of cigarettes and years of exposure to the smoker The increased risk was consistent with that expected from extrapolation of the risk in smokers using biochemical markers Tobacco specific carcinogens are found in the blood and urine of non-smokers exposed to environmental tobacco smoke All the available evidence confirms that exposure to environmental tobacco smoke causes lung cancer
Involvement of vascular endothelial growth factor in exercise induced bronchoconstriction in asthmatic patients
Authors: H Kanazawa
Journal: Thorax (2002)

<b>Background:</b> There is evidence that the bronchial microcirculation has the potential to contribute to the pathophysiological mechanisms of exercise induced bronchoconstriction (EIB) in asthmatic subjects. Vascular endothelial growth factor (VEGF), which is highly expressed in asthmatic airways, increases vascular permeability. The relationship between VEGF levels in induced sputum and the severity of EIB in asthmatic subjects was studied. <b>Methods:</b> The concentration of VEGF in induced sputum was examined in 23 asthmatic subjects and 11 normal controls. The asthmatic subjects performed an exercise test and the % maximal fall in forced expiratory volume in 1 second (FEV<sub>1</sub>) was measured. Beclomethasone dipropionate (BDP) 400 μg twice daily was administered to the asthmatic subjects for 8 weeks and the exercise test and sputum induction were repeated. <b>Results:</b> The concentration of VEGF in induced sputum was significantly higher in asthmatic subjects than in normal controls. There was a significant correlation between the concentration of VEGF and the % maximal fall in FEV<sub>1</sub> (<i>r</i>=0.826, p=0.0001) and between the concentration of VEGF and airway vascular permeability index (<i>r</i>=0.621, p=0.0037). After treatment with inhaled BDP there was a significant decrease in the concentration of VEGF in the asthmatic subjects (before treatment: 7051 (2361) pg/ml, after treatment: 4498 (2135) pg/ml, p&lt;0.0001). The change in the concentration of VEGF was significantly correlated with the change in the % maximal fall in FEV<sub>1</sub> (<i>r</i>=0.463, p=0.031). <b>Conclusions:</b> Excessive production of VEGF in asthmatic airways may contribute to the pathogenesis of EIB via increased airway vascular permeability.
Biologic Material in Needles and Cartridges After Insulin Injection With a Pen in Diabetic Patients
Authors: Jean-Pierre Le Floch, Catherine Herbreteau, Françoise Lange, Léon Perlemuter
Journal: Diabetes Care (1998)

To evaluate the frequency of non-inert material, including cells, in needles and cartridges after insulin injection with pen-like devices in diabetic patients.A prospective study was conducted in 120 insulin-treated diabetic patients who used pen-like devices. The patients, 46 women and 74 men, were 20-77 years old; 60% had type 1 diabetes, and 38% were overweight. Duration of diabetes ranged from 1 month to 40 years, and insulin therapy ranged from 1 month to 30 years. Insulin injection was performed by a trained nurse, using the patient's usual pen and cartridge. A cytopathological examination was performed on the material obtained from the needle and found in the cartridge after centrifugation. All slides were read by a single investigator.In 62% of the patients, non-inert material was found, including squamous (32%) and epithelial (58%) cells. Biologic material was found in 30% of the needles and 58% of the cartridges, and in both needle and cartridge in 25% of the population. Biologic material was found more frequently in patients who had a longer duration of diabetes, who were treated with insulin for a longer time, and who performed injection in the thighs or upper arms (P < 0.05). In multivariate analysis, the presence of biologic material was associated with the duration of diabetes (R2 = 0.09; P < 0.01).Our data suggest that biologic material can be trapped in the delivery system, including the cartridge, after an insulin injection with a pen-like device. Our results emphasize the strict need for individual use of insulin delivery systems, including cartridges and nonrefillable pens, especially in clinics and hospitals.
Biomedical Ethics in US Public Policy.
Authors: Robyn Y. Nishimi
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN IMPROVED CANNULA AND TROCAR FOR USE IN PARACENTESIS ABDOMINIS
Authors: Bryce W. Fontaine
Journal: JAMA (1925)

Difficulty in performing an aspiration recently prompted me to devise what I believe is a very practical cannula and trocar. I have had the parts made as illustrated, using an Ochsner cannula for gallbladder paracentesis, with two trocars—one, sharp or spearpointed, and one, rounded or blunt pointed—added to it. The chief difficulty encountered in paracentesis is a plugging up of the lumen of the cannula with a blood clot or lymph, or a closing of it by contact with the omentum, the mesentery or a coil of the intestines. After complete anesthesia (over a small area) of the skin, fascia, muscles and peritoneum, with a 2 per cent. solution of procain, a nick is made through the skin down to the peritoneum, with a sharp pointed scalpel. The cannula with the sharp or spearpointed trocar is introduced through the wound, and the peritoneum is punctured. As soon as the fluid