Late Appearance of Hyperlipemia in Hypopituitarism
Authors: DAVID R. JACOBS
Journal: Annals of Internal Medicine (1961)

Article1 October 1961Late Appearance of Hyperlipemia in HypopituitarismDAVID R. JACOBS, M.D., DOROTHY T. KRIEGER, M.D., RENE N. CHARLES, M.D.DAVID R. JACOBS, M.D.Search for more papers by this author, DOROTHY T. KRIEGER, M.D.Search for more papers by this author, RENE N. CHARLES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-640 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPituitary insufficiency is rarely reported to exist in association with an abnormal elevation in the serum triglycerides. In those instances where the two conditions have coexisted, except for the diabetic hyperlipemia occurring with acromegaly, attempts to attribute the lipid abnormality to a specific endocrine or metabolic defect were not usually made (1, 2). However, Tabatznik and Rabinowitz (3) demonstrated that the hyperlipemia in their hypopituitary patient, as well as in one described by Zollner (4), was reversible once the associated myxedema was corrected.The present report describes the appearance of unexplained hyperlipemia in three patients with pre-existing hypopituitarism. In two...References1. SMITHHOWARD CWRP: Variations in endocrine gland function in post-partum pituitary necrosis. J. Clin. Endocr. 19: 1420, 1959. CrossrefGoogle Scholar2. WILLIAMS RH: Textbook of Endocrinology, 2d Ed., W. B. Saunders Co., Philadelphia, 1956, p. 64. Google Scholar3. TABATZNIKRABINOWITZ BD: Hyperglyceridemia and lipemia retinalis in hypopituitarism. Bull. Johns Hopkins Hosp. 107: 175, 1960. MedlineGoogle Scholar4. ZOLLNER N: Hypopituitarismus (Sheehansches Syndrom) mit Hyperlipamie und Xanthomen. Deutsch. Med. Wschr. 80: 999, 1955, as cited in reference no. 3. CrossrefMedlineGoogle Scholar5. BRADBURYBROWNBROWN JTESWE: Adsorption of urinary gonadotrophins on kaolin. Proc. Soc. Exp. Biol. Med. 71: 228, 1949. CrossrefMedlineGoogle Scholar6. KLINEFELTERALBRIGHTGRISWOLD HFFGC: Experience with a quantitative test for normal or decreased amounts of follicle stimulating hormone in the urine in endocrinological diagnosis. J. Clin. Endocr. 3: 529, 1943. CrossrefGoogle Scholar7. HOLTORFFKOCH AFFG: Colorimetric estimation of 17-ketosteroids and their application to urine extracts. J. Biol. Chem. 135: 377, 1940. CrossrefGoogle Scholar8. PETERSONKARRERGUERRA REASL: Evaluation of the Silber-Porter procedure for determination of plasma hydrocortisone. Anal. Chem. 29: 144, 1957. CrossrefGoogle Scholar9. SILBERPORTER RHCC: Determination of 17, 21-dihydroxy-20-ketosteroids in urine and plasma. J. Biol. Chem. 210: 923, 1954. CrossrefMedlineGoogle Scholar10. SOFFERGABRILOVE LJJL: A simplified water-loading test for the diagnosis of Addison's disease. Metabolism 1: 504, 1952. MedlineGoogle Scholar11. SPERRYWEBB WMM: A revision of the Schoenheimer-Sperry method for cholesterol determination. J. Biol. Chem. 187: 97, 1950. CrossrefMedlineGoogle Scholar12. SPERRY WM: Electrophotometric microdetermination of phosphorus in lipid extracts. Industr. Engin. Chem., Anal. ed. 14: 88, 1942. Google Scholar13. BLOOR WR: Studies on blood fat. I. Variations in the fat content of the blood under approximately normal conditions. J. Biol. Chem. 19: 1, 1914. CrossrefGoogle Scholar14. TOMPSETTTENNANT SLWS: A method for determining esterified fatty acid with zone electrophoresis of serum proteins. Amer. J. Clin. Path. 26: 1226, 1956. CrossrefMedlineGoogle Scholar15. NELSON N: A photometric adaptation of the Somogyi method for the determination of glucose. J. Biol. Chem. 153: 375, 1944. CrossrefGoogle Scholar16. THANNHAUSER SJ: Lipoidoses: Diseases of the Intracellular Lipid Metabolism, Grune and Stratton, New York, 1958. Google Scholar17. HOLT LE: Lipemia, in Report of the Eleventh M & R Pediatric Research Conference, Johns Hopkins Hospital, Baltimore, 1945, pp. 28-30. Google Scholar18. CHARLES RN: Fibrinolysis and coagulation studies in inborn errors of lipid metabolism. To be published. Google Scholar19. FREDERICKSONGORDON DSRS: Transport of fatty acids. Physiol. Rev. 38: 585, 1958. CrossrefMedlineGoogle Scholar20. GOODMANKNOBIL HME: Mobilization of fatty acids by epinephrine in normal and hypophysectomized rhesus monkeys. Proc. Soc. Exp. Biol. Med. 100: 195, 1959. CrossrefMedlineGoogle Scholar21. HAUSBERGER FX: Action of insulin and cortisone on adipose tissue. Diabetes 7: 211, 1958. CrossrefMedlineGoogle Scholar22. BOSSAKWANGADLERSBERG ETCLD: Effects of long-term estrogen therapy on serum lipids and lipoproteins in inborn errors of lipid metabolism. Clin. Res. 5: 181, 1957. Google Scholar23. SEIFTERBAEDER JDH: Occurrence in plasma of an extractable lipid mobilizer (LM). Proc. Soc. Exp. Biol. Med. 91: 42, 1956. CrossrefMedlineGoogle Scholar24. SEIFTERBAEDERZARAFONETISKALAS JDHCJJ: Effect of adrenals, pituitary, liver and mucopolysaccharides on blood lipids, in Hormones and Atherosclerosis, Ed. by Pincus, G., Academic Press Inc., New York, 1959, pp. 265-79. CrossrefGoogle Scholar25. ZARAFONETISSEIFTERBAEDERKALAS CJJDHJ: Current clinical status of lipidmobilizer hormone. Arch. Intern. Med. 104: 974, 1959. CrossrefMedlineGoogle Scholar26. RUDMANSEIDMANREID DFMB: Lipemia-producing activity of pituitary gland: separation of lipemia-producing component from other pituitary hormones. Proc. Soc. Exp. Biol. Med. 103: 315, 1960. CrossrefMedlineGoogle Scholar27. JACOBS DR: Unpublished data. Google Scholar28. CHALMERSKEKWICKPAWAN TMAGL: On the fat-mobilising activity of human urine. Lancet 1: 866, 1958. CrossrefMedlineGoogle Scholar29. CHALMERSPAWANKEKWICK TMGLA: Hormonal nature of urinary fat-mobilising substance. J. Endocr. 20: xxi, 1960. Google Scholar30. HARVEYDE KLERK JCJ: The Houssay phenomenon in man. Amer. J. Med. 19: 327, 1955. CrossrefMedlineGoogle Scholar31. LUFTOLIVECRONA RH: Experiences with hypophysectomy in man. J. Neurosurg. 10: 301, 1953. CrossrefMedlineGoogle Scholar32. FELDMANROBERTSSUSSMANLIPETZ FJBDB: Coincidence of diabetes mellitus and hypopituitarism. Arch. Intern. Med. 79: 322, 1947. CrossrefGoogle Scholar33. MARTINPOND MMMH: Pituitary insufficiency associated with diabetes mellitus. J. Clin. Endocr. 14: 1046, 1954. CrossrefGoogle Scholar34. GRUNBERGBLAIR AJL: Hypopituitarism with consecutive development of diabetes mellitus. Brit. Med. J. 2: 439, 1957. CrossrefMedlineGoogle Scholar35. JHAVERI SS: Development of diabetes mellitus in hypopituitarism. Postgrad. Med. J. 35: 354, 1959. CrossrefMedlineGoogle Scholar36. MARTINSALASSASPRAGUE MJRMRG: The development of diabetes mellitus in a patient with pituitary insufficiency and renal glycosuria. Proc. Mayo Clin. 35: 414, 1960. MedlineGoogle Scholar37. HARRISALBRINKVAN ECKMANPETERS LVMJWFEBJP: Serum lipids in diabetic acidosis. Metabolism 2: 120, 1953. MedlineGoogle Scholar38. GREENBERGKLOTZBEARDWOOD SRRGJT: Lipoprotein elevations of diabetics on tolbutamide as compared to lipoprotein levels during insulin therapy: preliminary observations. Amer. J. Med. Sci. 241: 718, 1961. CrossrefMedlineGoogle Scholar39. JACOBS DR: Familial defect in lipid metabolism masked by diabetic hyperlipemia. J. Mount Sinai Hosp. N. Y. 27: 512, 1960. MedlineGoogle Scholar40. OLIVERBOYD MFGS: Endocrine aspects of coronary sclerosis. Lancet 2: 1273, 1956. CrossrefGoogle Scholar41. CONNVOGEL JWWC: Effects of prolonged adrenal cortical stimulation upon free and esterified cholesterol in normal man. J. Clin. Endocr. 9: 656, 1949. Google Scholar42. BLOOMPIERCE BFT: Relationship of ACTH and cortisone to serum lipoproteins and atherosclerosis in humans. Metabolism 1: 155, 1952. MedlineGoogle Scholar43. ADLERSBERGSCHAEFERDRACHMAN DLESR: Studies on hormonal control of serum lipid partition in man. J. Clin. Endocr. 11: 67, 1951. CrossrefGoogle Scholar44. JACOBS DR: Idiopathic hyperlipemia and diabetes mellitus. Deviations from normal lipid metabolism. J. Mount Sinai Hosp. N. Y. 27: 488, 1960. MedlineGoogle Scholar45. ADLERSBERG D: Inborn errors of lipid metabolism. Arch. Path. 60: 481, 1955. Google Scholar46. BARTHOLOMEWCOMFORT LGMW: Chronic pancreatitis without pain. Gastroenterology 31: 727, 1956. CrossrefMedlineGoogle Scholar47. MICKERSON JN: Anterior pituitary deficiency in disorders associated with steatorrhea. Brit. Med. J. 1: 529, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID R. JACOBS, M.D.; DOROTHY T. KRIEGER, M.D.; RENE N. CHARLES, M.D.Affiliations: New York, New YorkReceived for publication April 26, 1961.From the Endocrine Research Laboratory and Clinic and the Nutrition Research Laboratory of the Department of Medicine, and the Department of Chemistry, The Mount Sinai Hospital, New York, N. Y.Requests for reprints should be addressed to David R. Jacobs, M.D., Department of Medicine, The Mount Sinai Hospital, Fifth Avenue and 100th Street, New York 29, N. Y. 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