tbuckley/cabot-search huggingface dataset:
The epidemiology of atopic dermatitis in Italian schoolchildren
Authors: G. Girolomoni, D. Abeni, C. Masini, F. Sera, F. Ayala, A. Belloni‐Fortina, E. Bonifazi, P. Fabbri, C. Gelmetti, G. Monfrecola, A. Peserico, S. Seidenari, A. Giannetti
Journal: Allergy (2003)

Background: Atopic dermatitis (AD) is common in children in industrialized countries. Only one large population study on its prevalence has been conducted in Italy, based on self‐report questionnaire. The present study was designed to estimate the prevalence of AD in schoolchildren in Italy by dermatologists’ assessment and by UK Working Party criteria, and to investigate associated symptoms and factors. Methods: Cross‐sectional survey on a random sample of 9‐year‐old schoolchildren from seven Italian cities. Children were examined by experienced dermatologists. Parents and teachers answered standardized questionnaires. Results: Of the 1369 children examined, 88 had a diagnosis of AD, with an estimated point prevalence of 5.8% (95% CI 4.5–7.1) in the reference population. The reported lifetime prevalence was 15.2 (95% CI 12.2–18.2) for AD, 11.9% (95% CI 9.0–14.8) for asthma, and 17.6% (95% CI 14.6–20.7) for rhino‐conjunctivitis. The strongest associated factor was the presence of AD in at least one parent. No association of AD with maternal smoking during pregnancy, birth weight, maternal age at the time of the child birth and breast‐feeding was observed. The environmental characteristics of the house and the school did not correlate with the prevalence of AD. Episodes of lower respiratory tract infections were associated with asthma, and to a lower extent also with AD and rhinitis. Conclusions: The prevalence of doctor‐diagnosed AD in Italian schoolchildren is comparable to those reported for other developed countries. Family history of atopy was the single most important associated factor, while the complex interplay of environmental factors remains to be elucidated.
Changes in dry weight and projected area of human epidermal cells undergoing keratinization as determined by scanning interference microscopy
Authors: H.J. YARDLEY, D.J. GOLDSTEIN
Journal: British Journal of Dermatology (1976)

Cells, obtained from human leg by successive treatments with trypsin, were air dried on microscope slides before mounting in glycerol. Dry weights and projected areas of individual cells were measured using a Vickers M 86 scanning microinterferometer. The dry weights of cells varied from 100 pg for basal cells to 700 pg for large squames. Corresponding projected areas varied from 100 to 1500 mum2.
ANCA patients have T cells responsive to complementary PR-3 antigen
Authors: Jiajin Yang, David J. Bautz, Sofia Lionaki, Susan L. Hogan, Hyunsook Chin, Roland M. Tisch, John L. Schmitz, Barrak M. Pressler, J. Charles Jennette, Ronald J. Falk, Gloria A. Preston
Journal: Kidney International (2008)
Pure red-cell aplasia: association with systemic lupus erythematosus and primary autoimmune hypothyroidism.
Authors: D A Francis
Journal: BMJ (1982)

Pure red-cell aplasia: association with systemic lupus erythematosus and primary autoimmune hypothyroidism Pure red-cell aplasia has been reported in association with several autoimmune disorders, but not with primary autoimmune hypothyroidism.This report confirms another link between pure red-cell aplasia and altered autoimmunity.
IS STENT FRACTURE STILL A PROBLEM IN THE ERA OF THE SECOND-GENERATION DRUG-ELUTING STENT?
Authors: SukMin Seo, Kiyuk Chang, Mahnwon Park, Eunho Choo, Jihee kim, Yoonseok Koh, Woobaek Chung, Minseok Choi, Sunggyu Yoon, Hunjun Park, Hunjun Park, Hunjun Park, Hunjun Park, Hunjun Park, Hunjun Park, Wooksung Chung, Wooksung Chung, Kibae Seung
Journal: Journal of the American College of Cardiology (2010)
Bodybuilders find it easy to obtain insulin to help them in training
Authors: S L Elkin, S Brady, I P Williams
Journal: BMJ (1997)

Editor—We have recently been involved in the care of a 21 year old amateur bodybuilder, who was admitted after taking an excessive amount of insulin intravenously. He developed severe brain damage after prolonged neuroglycopenia. His case brought several points to our attention. Since anabolic steroids have been designated illegal in competitive sport, athletes have been looking for alternative drugs to help them put on muscle mass and burn off fat. With …
INDOOR AIR QUALITY: Wood-Burning Stoves Get Help from HEPA Filters
Authors: Carol Potera
Journal: Environmental Health Perspectives (2011)

international environmental health assessing the Global Composite impact of Chemicals on healthThe total role that the environment plays in contributing to premature death and disability remains sketchy, but researchers working with the World Health Organization (WHO) continue to flesh out the details.Now four WHO researchers have estimated the global burden of certain toxic substances for which adequate data are available. 1They have calculated that in 2004 2 at least 8.3% of all preventable deaths and 5.7% of the preventable portion of the metric known as disability-adjusted life years (DALYs, which address a blend of death and disease impacts) were caused by the toxics analyzed. 1Their estimates include health end points such as cardiovascular disease, cancers, neuropsychiatric disorders, asthma, chronic obstructive pulmonary disease, respiratory infections, and birth defects. 3 The leading contributors to premature death and DALYs were indoor solid fuel combustion (1,965,000 deaths and 41,009,000 DALYs), outdoor air pollution (1,212,000 deaths and 8,747,000 DALYs), secondhand tobacco smoke (SHS; 603,000 deaths and 10,913,000 DALYs), chronic occupational exposures (581,000 deaths and 6,763,000 DALYs), chemicals involved in unintentional, nonoccupational acute poisonings (210,000 deaths and 4,603,000 DALYs), and suicide attempts using pesticides (186,000 deaths and 4,420,000 DALYs).Other toxics included in the global totals were asbestos, lead, arsenic in drinking water (but only in Bangladesh), and a few other chemicals, including some typically encountered in occupational settings. 1 Children under age 15 years were a highly susceptible group, suffering 54% of the total DALY burden.That includes 80% of the burden imposed by lead, 75% of that of indoor solid fuel use, 61% of that of SHS, 19% of
Recurrent involvement of ring-type zinc finger genes in complex molecular rearrangements in childhood acute myelogeneous leukemia with translocation t(10;11)(p12;q23)
Authors: S Ghosh, C Bartenhagen, V Okpanyi, M Gombert, V Binder, A Teigler-Schlegel, J Bradtke, S Röttgers, M Dugas, A Borkhardt
Journal: Leukemia (2013)
Expansion of Invasive Cardiac Services in the United States
Authors: Jill R. Horwitz, Austin Nichols, Brahmajee K. Nallamothu, Comilla Sasson, Theodore J. Iwashyna
Journal: Circulation (2013)

The number of hospitals offering invasive cardiac services (diagnostic angiography, percutaneous coronary intervention, and coronary artery bypass grafting) has expanded, yet national patterns of service diffusion and their effect on geographic access to care are unknown.This is a retrospective cohort study of all hospitals in fee-for-service Medicare, 1996 to 2008. Logistic regression identified the relationship between cardiac service adoption and the proportion of neighboring hospitals within 40 miles already offering the service. From 1996 to 2008, 397 hospitals began offering diagnostic angiography, 387 percutaneous coronary intervention, and 298 coronary artery bypass grafting (increasing the proportion with services by 3%, 11%, and 4%, respectively). This capacity increase led to little new geographic access to care; the population increase in geographic access to diagnostic angiography was 1 percentage point; percutaneous coronary intervention 5 percentage points, and coronary artery bypass grafting 4 percentage points. Controlling for hospital and market characteristics, a 10 percentage point increase in the proportion of nearby hospitals already offering the service increased the odds by 10% that a hospital would add diagnostic angiography (odds ratio, 1.102; 95% confidence interval, 1.018-1.193), increased the odds by 79% that it would add percutaneous coronary intervention (odds ratio, 1.794; 95% confidence interval, 1.288-2.498), and had no significant effect on adding coronary artery bypass grafting (odds ratio, 0.929; 95% confidence interval, 0.608-1.420).Hospitals are most likely to introduce new invasive cardiac services when neighboring hospitals already offer such services. Increases in the number of hospitals offering invasive cardiac services have not led to corresponding increases in geographic access.
Acute Tubular Necrosis in a Renal Transplant Recipient
Authors: Jimmy A. Light
Journal: JAMA (1975)

HISTORICALLY, the chief technical problem in renal transplantation has been the reconstruction of the urinary tract.<sup>1</sup>For this reason, we have performed routine drip-infusion excretory urography in the early posttransplantation period, as soon as renal function became adequate to permit visualization of the collecting system and ureter. Thus, small leaks masked by catheter drainage might be detected and repaired prior to catheter removal and clinical manifestations. Furthermore, the differential diagnosis of subsequent oliguria would be simplified by knowing that the urinary tract was anatomically normal. These studies had been performed in more than 40 patients and were thought to be harmless until the experience cited in this brief article was encountered. <h3>Report of a Case</h3> A 24-year-old woman with a history of chronic glomerulonephritis since childhood had been undergoing hemodialysis for one year prior to receiving a kidney transplant from her 44-year-old father. An uncomplicated transplantation was performed in
Large Cell-Small Cell Bronchogenic Carcinoma
Authors: Gerald Vosika
Journal: JAMA (1979)

To the Editor.—  My article Large Cell Bronchogenic Carcinoma: Prolonged Disease-Free Survival Following Chemotherapy, which was published inThe Journal(241:594, 1979), attracted considerable attention. I designated the case as a large cell carcinoma because of the following: (1) The original pathological diagnosis made in 1973 was that of an undifferentiated  (2) This diagnosis was confirmed in 1973 by the pathologist then in charge of the Division of Surgical Pathology at the University of Minnesota, who reviewed the tissue. (3) Elements consistent with large cell carcinoma were present. (4) The tumor was not designated by any of the original pathologists as a small cell carcinoma.  After the article's publication, Dr Mary Matthews, of the National Cancer Institute-Veterans Administration Medical Oncology Branch, VA Medical Center, Washington, DC, requested that the slides be sent to her for review. It is her impression that this case represents what is currently being classified as
Efficiency of Human Insulin (recombinant DNA) in the Treatment of Diabetic Ketoacidosis and Severe Nonketoacidotic Hyperglycemia
Authors: Werner Bachmann, Helmut Walter, Norbert Lotz, Hellmut Mehnert
Journal: Diabetes Care (1982)

Human insulin (recombinant DNA) was compared with pork insulin in the treatment of diabetic ketoacidosis and severe nonketoacidotic hyperglycemia using a continuous, intravenous, low-dose regimen. Seven patients (age range 48 ± 26 yr, mean ± SD) with diabetic ketoacidosis and three (52, 65, and 70 yr) with nonketoacidotic hyperglycemia were studied. In the ketoacidotic group the initial values of blood glucose, pH, and base excess were 808 ± 353 mg/dl, 7.06 ± 0.1 , and −22.8 ± 5.9 mmol/L, respectively. The mean initial values of blood glucose and osmolality of the three patients with nonketoacidotic hyperglycemia were 731 ± 127 mg/dl and 355 ± 49 mosmol/kg, respectively. Within 24 h insulin therapy led to continuous improvement in blood glucose to 187 ± 90 (ketoacidotic patients) and 172 ± 28 mg/dl (nonketoacidotic group) and normalization of pH, base excess, and osmolality. The mean insulin requirement was 84 ± 45 U/24 h in ketoacidotic and 86 ± 18 U/24 h in nonketoacidotic patients, respectively. The comparison groups receiving pork insulin did not differ significantly in either clinical or initial and subsequent biochemical data or in insulin requirement.
Author Perception of Peer Review
Authors: Ellen J. Weber, Patricia P. Katz, Joseph F. Waeckerle, Michael L. Callaham
Journal: JAMA (2002)

To determine author perception of peer review and association between quality of review and author satisfaction.Survey between May 1999 and October 2000 of 897 corresponding authors of manuscripts under consideration by the Annals of Emergency Medicine and had received final editorial decisions during the study period. A total of 576 authors (64%) returned the survey. Using a 5-point Likert scale, the survey assessed differences in satisfaction between authors whose manuscripts were accepted, reviewed and rejected, and rejected without full review. The association of author satisfaction with editor's assessment of review quality, publication decision, author sex, specialty, and publication experience were also assessed.Overall mean (SD) satisfaction score, indicated by agreement with "My experience with the review process will make me more likely to submit to Annals in the future," was 3.1 (1.0) and was significantly higher among authors of accepted papers (3.7 [0.9]) than among either group of rejected papers (rejected/reviewed, 2.8 [1.0]; rejected/no review, 3.0 [0.9]; P.05). Authors whose manuscripts were reviewed and rejected were the least satisfied with the time to decision (rejected/reviewed, 3.0 [1.2] vs accepted, 3.7 [1.0] and rejected/no review, 3.9 [0.9]; P<.05). Those whose papers were rejected without review were the least satisfied with the letter explaining the editorial decision (rejected/no review, 2.8 [1.2] vs accepted, 4.2 [0.7] and rejected/reviewed, 3.1 [1.2]; P<.05). Among respondents whose manuscripts underwent full review (accepted and rejected/reviewed), overall satisfaction was highly associated with acceptance of the manuscript for publication (odds ratio [OR], 6.12; 95% confidence interval [CI], 3.43-10.91) but not with quality rating of reviews (OR, 1.26; 95% CI, 0.84-1.90).Contributor satisfaction with peer review was modest. Authors of rejected manuscripts were dissatisfied with the time to decision and communication from the editor. Author satisfaction is associated with acceptance but not with review quality.
Respiratory distress syndrome in infants of Cardiff residents during 1965-75.
Authors: I Chalmers, M E Dauncey, E R Verrier-Jones, J A Dodge, O P Gray
Journal: BMJ (1978)

The incidence of respiratory distress syndrome (RDS) among singleton infants of Cardiff residents was greater during 1970-4 than in the preceding five years. This was consistent with changes in the distribution of gestational age and birth weight. Case fatality rates among infants with RDS fell only slightly during the period examined. Detailed examination of secular trends during 1965-75 suggested (a) that increased use of elective delivery without assessment of pulmonary maturity increases the risk of RDS, and (b) that innovations in the management of RDS during the early 1970s cannot be assumed to have had widespread impact on case fatality rates.
Association of primary biliary cirrhosis with the allele HLA-DPB1*0301 in a German population
Authors: Juan G. Mella, Elke Roschmann, Klaus-Peter Maier, Brigitte A. Volk
Journal: Hepatology (1995)

The major histocompatibility complex class II alleles at the HLA-DPB1 locus were investigated in 32 German Caucasoid patients with primary biliary cirrhosis (PBC) and compared with those from 47 normal control patients using molecular genotyping techniques. The second exon of the HLA-DPB1 gene was amplified by polymerase chain reaction (PCR) and hybridized with 25 sequence-specific oligonucleotides (SSOs) to assign the HLA-DPB1 alleles on the basis of known sequence variations, according to the protocols of the Eleventh International Histocompatibility Workshop. A strong association of PBC was found with the allele HLA-DPB1*0301. The allele HLA DPB1*0301 was present in 50% (16 of 32) of the patients with PBC compared with 13% (6 of 47) or normal controls ( P corrected &lt; .015), whereas the other HLA-DPB1 alleles showed no significant differences in both groups. The relative risk (RR) estimate for the allele HLA-DPB1*0301 was 6.8 (95% confidence limits: 2.27 to 20.57). In summary, this study clearly demonstrates an association of PBC with the HLA-DPB1*0301 allele in German Caucasoids and may add new data to the immunogenetic background of PBC, suggesting a contribution of the HLA-DPB1 gene to the genetic susceptibility of the disease. (Hepatology 1995;21:398-402.)
Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation
Authors: Bram Trachet, Rodrigo A. Fraga-Silva, Alessandra Piersigilli, Alain Tedgui, Jessica Sordet-Dessimoz, Alberto Astolfo, Carole Van der Donckt, Peter Modregger, Marco F. M. Stampanoni, Patrick Segers, Nikolaos Stergiopulos
Journal: Cardiovascular Research (2014)

AimsIn this work, we provide novel insight into the morphology of dissecting abdominal aortic aneurysms in angiotensin II-infused mice. We demonstrate why they exhibit a large variation in shape and, unlike their human counterparts, are located suprarenally rather than infrarenally.
Partograms and Nomograms of Cervical Dilatation in Management of Primigravid Labour
Authors: J. Studd
Journal: BMJ (1973)

Philpott's graphic labour has been modified and used in 15,000 labours; it has been unanimously accepted by the staff. A nomogram has been constructed to show the normal progressive dilatation of the cervix for primigravidae admitted at different stages of cervical dilatation. Retrospective evaluation of the nomogram showed that it can separate normal labour from labour destined to result in an abnormal outcome, such as longer first and second stages, a greater incidence of instrumental delivery, and babies with low Apgar scores.It is suggested that the use of a stencil representing normal labour progress, together with Philpott's partogram, will be of considerable use, both in specialist and in general-practitioner units.
The relationship between brain tumor cell invasion of engineered neural tissues and in vivo features of glioblastoma
Authors: Zeynab Nayernia, Laurent Turchi, Erika Cosset, Hedi Peterson, Valérie Dutoit, Pierre-Yves Dietrich, Diderik Tirefort, Hervé Chneiweiss, Johannes-Alexander Lobrinus, Karl-Heinz Krause, Thierry Virolle, Olivier Preynat-Seauve
Journal: Biomaterials (2013)
Tumor endothelial marker 1–specific DNA vaccination targets tumor vasculature
Authors: John G. Facciponte, Stefano Ugel, Francesco De Sanctis, Chunsheng Li, Liping Wang, Gautham Nair, Sandy Sehgal, Arjun Raj, Efthymia Matthaiou, George Coukos, Andrea Facciabene
Journal: Journal of Clinical Investigation (2014)

Tumor endothelial marker 1 (TEM1; also known as endosialin or CD248) is a protein found on tumor vasculature and in tumor stroma. Here, we tested whether TEM1 has potential as a therapeutic target for cancer immunotherapy by immunizing immunocompetent mice with Tem1 cDNA fused to the minimal domain of the C fragment of tetanus toxoid (referred to herein as Tem1-TT vaccine). Tem1-TT vaccination elicited CD8+ and/or CD4+ T cell responses against immunodominant TEM1 protein sequences. Prophylactic immunization of animals with Tem1-TT prevented or delayed tumor formation in several murine tumor models. Therapeutic vaccination of tumor-bearing mice reduced tumor vascularity, increased infiltration of CD3+ T cells into the tumor, and controlled progression of established tumors. Tem1-TT vaccination also elicited CD8+ cytotoxic T cell responses against murine tumor-specific antigens. Effective Tem1-TT vaccination did not affect angiogenesis-dependent physiological processes, including wound healing and reproduction. Based on these data and the widespread expression of TEM1 on the vasculature of different tumor types, we conclude that targeting TEM1 has therapeutic potential in cancer immunotherapy.
THE DIAGNOSTIC ACCURACY OF 64-SLICE CT ANGIOGRAPHY USING CONTRAST DENSITY GRADIENT ANALYSIS FOR THE DETECTION OF IN-STENT RESTENOSIS AFTER LEFT MAIN CORONARY STENTING
Authors: Kushal Dighe, Waseem Sharieff, Payam Dehghani, Danny Marcuzzi, Vikram Prabhudesai, Tej Sheth, Ian Billingsley, Warren Ball, Asim Cheema
Journal: Journal of the American College of Cardiology (2013)
Abstract 4236: Characterization of maternal embryonic leucine zipper kinase in cancer stem/progenitor cells
Authors: Yuko Okemoto-Nakamura, Harley I. Kornblum, Ichiro Nakano
Journal: Cancer Research (2010)

Abstract Glioblastoma multiforme (GBM) is the most frequent tumor in the adult brain and remains a highly lethal diseases. Recent studies have suggested that lack of targeted therapies for brain tumor stem cells (BTSC) is one of the reasons for the limited efficacy of the current therapies. Identification of the molecular target in BTSC is crucial to the development of GBM therapy. Maternal embryonic leucine zipper kinase (MELK) is a member of Snf1/AMP serine/threonine kinase family and abundantly expressed in multiple cancers, including GBM. Previously, we demonstrated that the RNA expression of MELK is elevated in patient-derived tumor stem-like cells in GBM. Knockdown of MELK of tumor stem-like cells by siRNA resulted in apoptosis in vitro. In contrast, knockdown of MELK did not induce significant apoptosis in normal neural progenitors derived from mouse brains, raising a possibility that MELK is likely required for survival of tumor stem cells but not the normal counterpart. However, the difference in the mechanism of MELK action between tumor and normal stem cells is unknown. Here we investigated to discriminate the signaling pathways that regulate survival and proliferation of BTSC and normal neural stem cells. Immunohistochemistry showed that MELK is abundantly expressed in surgical specimens of GBM and is mainly localized in the nuclei. Immunocytochemistry with patient-derived GBM spheres demonstrated that MELK is preferentially expressed by GBM stem-like cells but not in the differentiated tumor cells. We also found that MELK is phosphorylated at serine and threonine residues in GBM stem-like cells. To determine the signaling pathways that regulate MELK phophorylation in GBM stem cells, we treated GBM stem-like cells with a variety of the kinase inhibitors. Interestingly, a mitogen-activated protein (MAP) kinase inhibitor reduced the MELK protein expression in GBM stem-like cells but not in the normal counterpart. The MAP kinase pathway was up-regulated in GBM stem-like cells in comparison to the normal progenitors derived from human fetal brains, further supporting the significance of this pathway in GBM stem cells. Collectively, our data indicate that MAP kinase may regulate MELK phosphorylation and activation specifically in GBM stem cells but not in the normal neural stem cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4236.
Initiatives to improve childhood immunisation uptake: a randomised controlled trial
Authors: M. Z Morgan, M. R Evans
Journal: BMJ (1998)

received a booster dose.H influenzae type b polysaccharide IgG responses are shown in the table.The proportions of children who had antibody titres below the minimum protective level of 0.15 g/ml before receiving their booster dose at 1 year of age was higher than previously reported with the more extended primary immunisation schedule. 5 The mean increase in antibody titre after administration of the booster dose was 803-fold (95% confidence interval 651 to 955).