tbuckley/cabot-search huggingface dataset:
Is the Incidence of Diabetes Increasing in All Age-Groups in The Netherlands?: Results of the second study in the Dutch Sentinel Practice Network
Authors: Dirk Ruwaard, Ronald Gijsen, Aad I M Bartelds, Remy A Hirasing, Harry Verkleij, Daan Kromhout
Journal: Diabetes Care (1996)

To assess possible changes in the incidence of diabetes in all age-groups in The Netherlands during a 10-year period (1980-1983/1990-1992).Since 1970, a network of sentinel stations (the Dutch Sentinel Practice Network) consisting of approximately 1% of the Dutch population has been in operation to gain insight into the morbidity patterns of the Dutch population as recorded by general practitioners. One of the items recorded from 1990 to 1992 was the incidence of diabetes. The first study with a similar design that registered the incidence of diabetes was conducted from 1980 to 1983.The overall incidence of diabetes increased significantly by 12.1% in the period between the two studies. This overall increase can largely be attributed to a statistically significant increase in the age-group 45-64 years (30.5%). Although not statistically significant, the 36% increase of diabetes in the age-group 0-19 years is in accordance with the increase of type I diabetes based on the first and second nationwide retrospective studies covering the total Dutch population.There is a marked increase in the incidence of diabetes in the age-group 45-64 years. This selective increase is probably not due to a real rise caused by changes in exposure to risk factors but to an earlier recognition of symptoms and signs of diabetes followed by blood glucose measurements and/or to more intensive case finding in general practice.
Antibiotics Other Than Penicillin in the Treatment of Syphilis
Authors: C. Hunter Montgomery, John M. Knox
Journal: New England Journal of Medicine (1959)

THE increasing concern over penicillin sensitivity reactions has created a need for information on the use of other antibiotics for the treatment of syphilis. Although studies have been performed on most antibiotics, there is still confusion about their efficacy and the optimum dosage schedules. The following is a review of the English literature on antibiotics other than penicillin in the treatment of syphilis.ChlortetracyclineThe first published reports on the clinical use of this drug in treating syphilis were those of O'Leary and his associates1 2 3 and Kierland et al.4 , 5 in 1948. They reported the cases of 2 patients with early . . .
Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)
Authors: Adrian A. Lobito, Fiona C. Kimberley, Jagan R. Muppidi, Hirsh Komarow, Adrianna J. Jackson, Keith M. Hull, Daniel L. Kastner, Gavin R. Screaton, Richard M. Siegel
Journal: Blood (2006)
The “Right” to Fall
Authors: Zaldy S Tan
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cameron announces plan for seven day access to GPs
Authors: G. Iacobucci
Journal: BMJ (2013)

The prime minister has set out plans for patients in England to be able to see a GP any day of the week and in evenings.

The move is intended to make it easier for people to see their GP from 8 am to 8 pm, seven days a week. The extended hours will be piloted in nine areas, which will also trial other new services designed to increase convenience for patients, including greater use of consultations by email, telephone, and internet videoconferencing.

Launching the policy at the Conservative Party’s conference this week, David Cameron said that the government would put £50m (€60m; $80m) into the pilot scheme, to be …
A new elastic system component, 'elastic sheet' in the human dermis. An electron microscopic study
Authors: T. TSUJI
Journal: British Journal of Dermatology (1988)

We have studied a new component of the elastic fibre system in the human dermis, which we call 'elastic sheet', using scanning and transmission electron microscopy. The structure is long, broad and flat with some holes, and may be the base of the elastic fibre system from which elastic fibres originate.
At the Bedside
Authors: John H. Talbott
Journal: New England Journal of Medicine (1967)

MINDFUL of the honor bestowed upon me in delivering the Annual Discourse for 1967, I shall attempt to justify the breach of silence. With this remark my thoughts return to my professor of botany in college, an especially devout Quaker from Haverford College. It is recognized that the Society of Friends contains some of the finest people in the world who teach by admonition. One of my professor's favorite admonition was: "Don't speak unless you can improve on the silence."Any physician worthy of emulation rarely achieves this enviable station without integrating effectively the science and learning of a philosopher . . .
Millions of US children do not get the recommended preventive care, CDC reports
Authors: M. McCarthy
Journal: BMJ (2014)

Millions of infants, children, and adolescents in the United States are not receiving the recommended preventive care, the Centers for Disease Control and Prevention (CDC) has reported. 

The report1 focused on 11 preventive services: prenatal breastfeeding counseling, newborn hearing screening and follow-up, developmental screening, lead screening, vision screening, hypertension screening, dental care and preventive dental services, human papillomavirus vaccination, tobacco use screening and help in quitting, chlamydia screening, and reproductive health services. The report appeared as a supplement to the 12 September issue of the CDC’s Morbidity & Mortality …
Repetitive strain injury Examine working practices
Authors: A Seaton
Journal: BMJ (1994)

EDITOR,- The subtitle of Peter Brooks's editorial on repetitive strain injury (Does not exist as a separate medical condition), if not the editorial itself, risks seriously misleading the medical profession to the detriment of people doing manual work.1 The subtitle will reinforce the prejudices of those doctors who believe that all people who attribute their ill health to their work are malingerers or potential litigants. The editorial does, however, hint at …
Changing of the Medical Guard in Croatia
Authors: Phil Gunby
Journal: JAMA (1994)

THE US NAVY now will be providing medical support for the 28000 troops from 24 nations that make up the United Nations Protection Force for the wartorn Balkans. Richard I. Ridenour, MD, a two-star admiral who now is deputy surgeon general of the US Navy (<i>JAMA</i>. 1991;265: 692-693), was present last week as naval medical personnel began taking over from US Air Force physicians, nurses, and technicians at Camp Pleso Air Base in the Zagreb, Croatia, northern region of the former Yugoslavia. US Army medical personnel were the first to provide medical support, arriving in November 1992 and subsequently being relieved by a US Air Force air transportable hospital team. See also p 898. In its first 6 months in Croatia, the US Army's 212th MASH (Mobile Army Surgical Hospital) treated more than 5000 patients from 35 nations and performed more than 200 surgical procedures in its 60-bed facility. Between
Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking
Authors: Fuxian Zhang, Zhenhua Zheng, Shu-Lin Liu, Wen Lu, Zhenfeng Zhang, Cuiling Zhang, Peng Zhou, Yuan Zhang, Gang Long, Zhike He, Dai-Wen Pang, Qinxue Hu, Hanzhong Wang
Journal: Biomaterials (2013)
Mandatory Reporting of Infectious Diseases by Clinicians
Authors: Terence L. Chorba
Journal: JAMA (1989)

Reporting of cases of communicable disease is important in the planning and evaluation of disease prevention and control programs, in the assurance of appropriate medical therapy, and in the detection of common-source outbreaks. In the United States, the authority to require notification of cases of disease resides in the respective state legislatures. We examined the laws and regulations of health departments of all US jurisdictions to ascertain diseases and conditions currently required to be reported in each state or territory. We present herein the state reporting requirements for infectious diseases and infectious disease—related conditions. To obtain additional information regarding time frames for reporting, agencies to which reports are required, persons required to report, and specific conditions under which reports are required, the reader is referred to the statutes and health department regulations of the respective states. (<i>JAMA</i>. 1989;262:3018-3026)
More Medical Faculties— The Need and Supply
Authors: E. D. Pellegrino
Journal: JAMA (1966)

An academical system without the personal influence of teachers upon pupils is an Arctic winter; it will create an icebound, petrified, cast iron university and nothing else."<sup>1</sup> The essential experience in a university—and this is uniquely so in a medical school—will always remain the personal confrontation of students and faculty to which Cardinal Newman so perceptively alluded. While this experience is the necessary point of return in any discussion of faculty supply, it can no longer be assured by attention to numbers of faculty alone. Any estimates of the prospective supply of faculty to staff new medical schools and expand the capabilities of existing schools is increasingly complicated by the new and multiple functions demanded by society of medical faculties and medical centers. Can the expanding responsibilities confronting medical schools be met and still preserve traditional teaching functions, even in the next decade? This is a question which clearly
APPENDICITIS WITH PURULENT PERITONITIS.
Authors: J. G. CARPENTER
Journal: JAMA (1897)

In presenting this subject the writer wishes to deal with its pathology and surgical treatment; and report successful clinics that have occurred in private country practice with the giants of the profession, viz., the general practitioners. There is no theme of more surgical importance than appendicitis, with or without perforation and gangrene. Whether we be physicians, general or abdominal surgeons, sooner or later we must confront suppurative appendicitis with purulent peritonitis. As a rule the general practitioner is the first to see these cases. Upon his knowledge of pathology, early diagnosis, complications and surgical treatment, hangs the life and destiny of the patient; and it is incumbent upon him to give the danger signal, operate, or call a surgeon who will, and save life. Not an ideal, but life-saving, conservative surgery. It is not so much how many operations are performed, as how many lives can be saved? For a
Poetry and Medicine
Authors: Ronald Pies
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recombinant Human Tumor Necrosis Factor Administered as a 24-Hour Intravenous Infusion. A Phase I and Pharmacologic Study
Authors: D. R. Spriggs, M. L. Sherman, H. Michie, K. A. Arthur, K. Imamura, D. Wilmore, E. Frei, D. W. Kufe
Journal: JNCI Journal of the National Cancer Institute (1988)

Recombinant human tumor necrosisj factor (rH-TNF) is a cytokine with direct antitumor properties. In a phase I trial we continuously infused rH-TNF for 24 hours. We gave a total of 115 courses of therapy to 50 patients. Doses ranged from 4.5 to 645 μg of rH-TNF/m2. Systemic toxicity, including fever, chills, fatigue, and hypotension, increased with the does of rH-TNF administered. Doses >454 μg/m2 frequently caused severe lethargy and fatigue, which precluded hospital discharge of the patient at the completion of therapy. The dose-limiting toxicity was gypotension, and five patients treated at the two high3est dose levels requirede dopamine treatment. Other organ-specific toxicity was modest and spontaneously resolved after 48hours. The24-hour infusions of rH-TNF were associated weith significant decreases in serum cholesterol and high-density lipoprotein levels. Pharmacokinetic studies using an enzyme-linked immunosorbent assay demonstrated peak plasma rH-TNF levels of 90-900 pg/mL. Despite continuous infusion of rH-TNF. no steady-state level was achieved. The recommended phase II dose for rH-TNF as a 24-hour continuous infusion is 545 μg/m2. [Natl Cancer Inst 1988;80:1039–1044]
Chemical and biological weapons: new questions, new answers.
Authors: E Hood
Journal: Environmental Health Perspectives (1999)

The words "chemical and biological weapons" (CBW) send a shiver down most spines these days. With the end of the Cold War, the possibility of a massive nuclear confrontation appears remote, so today many popular doomsday scenarios center on the aggressive use of chemical or biological warfare by rogue nations or terrorist groups. As exaggerated as some of the accounts are, with CBW cast as the latest unseen, unstoppable enemy, the threat posed by these weapons is all too real, and growing.
Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus
Authors: Wojciech Wojciechowski, David P. Harris, Frank Sprague, Betty Mousseau, Melissa Makris, Kim Kusser, Tasuko Honjo, Katja Mohrs, Markus Mohrs, Troy Randall, Frances E. Lund
Journal: Immunity (2009)
Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter.
Authors: B Grubeck-Loebenstein, G Buchan, R Sadeghi, M Kissonerghis, M Londei, M Turner, K Pirich, R Roka, B Niederle, H Kassal
Journal: Journal of Clinical Investigation (1989)

The production and growth regulatory activity of transforming growth factor beta were studied in human thyroid tissue. As estimated by its mRNA expression in fresh tissue samples, transforming growth factor beta was produced in normal and in diseased thyroid glands. Transforming growth factor beta mRNA was mainly produced by thyroid follicular cells and in lesser quantities by thyroid infiltrating mononuclear cells. The concentrations of transforming growth factor beta mRNA were lower in iodine-deficient nontoxic goiter than in Graves' disease and normal thyroid tissue. Transforming growth factor beta protein secretion by cultured thyroid follicular cells was also low in nontoxic goiter, but could be increased by addition of sodium iodide (10 microM) to the culture medium. Recombinant transforming growth factor beta did not affect basal tritiated thymidine incorporation in cultured thyroid follicular cells, but inhibited, at a concentration of 10 ng/ml, the growth stimulatory influence of insulin-like growth factor I, epidermal growth factor, transforming growth factor alpha, TSH, and partly that of normal human serum on cultured thyroid follicular cells. This inhibition was greater in Graves' disease than in nontoxic goiter. These results suggest that transforming growth factor beta may act as an autocrine growth inhibitor on thyroid follicular cells. Decreased transforming growth factor beta production and decreased responsiveness to transforming growth factor beta may be cofactors in the pathogenesis of iodine-deficient nontoxic goiter.
481 SHOULD HBsAg-POSITIVE GRAFTS CONSIDERED MARGINAL FOR ORTHOTOPIC LIVER TRANSPLANTATION? SINGLE CENTER EXPERIENCE
Authors: E. Loggi, L. Micco, S. Gitto, S. Lorenzini, M. Biselli, C. Sanrocco, G. Ercolani, G.L. Grazi, M. Bernardi, A.D. Pinna, P. Andreone
Journal: Journal of Hepatology (2009)
Thinking in Pictures: And Other Reports From My Life With Autism
Authors: Edwin J. Mikkelsen
Journal: JAMA (1996)

The title<i>Thinking in Pictures: And Other Reports From My Life With Autism</i>would suggest a first-person account of an individual's experiences with autism. In fact, the book is much more. In it, Temple Grandin, PhD, provides not only a vivid account of her life, but also an extensive overview of the state of knowledge about autism. The primary focus is, of course, Temple Grandin's experiences as they relate to her life with autism. I have never had the opportunity of attending one of Grandin's many lectures. However, I have heard about them and about her earlier writings for years, and have always wondered how someone who is described as autistic could be so successful at communication. Thus, it was with some skepticism that I undertook to review her book. Having finished it, I am satisfied that her unique personality traits and cognitive idiosyncracies do place her on "the great
Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date
Authors: Don E. Griswold, Jerry L. Adams
Journal: Medicinal Research Reviews (1996)

While a great deal has been discovered concerning the potential physiological and pathological role of prostanoids, much is left to be determined. The widespread distribution of both COX-1 and COX-2 coupled with the capacity of most vascular beds, smooth muscle, as well as leukocytes to respond to prostanoids make drawing generalities difficult. The problems with the majority of currently used NSAIDs are clear and ulcerogenic liability is of obvious concern. Interestingly enough, the mechanism of that damage is still the subject of controversy as illustrated by the recent review and hypothesis of Somasundaram et al. In this treatise, the suggestion is made that the initial gastric damage is the result of uncoupling of oxidative phosphorylation which is independent but simultaneous with COX inhibition. At least two currently marketed NSAIDs have improved G.I. liability (nabumetone and etodolac) with efficacy equivalent to other more ulcerogenic NSAIDs. These drugs appear to have achieved that by a mechanism distinct from selective inhibition of COX-2. Whether or not selective COX-2 inhibitors will demonstrate an improved profile over these compounds remains to be shown. Unfortunately, clinical experience with nimsulide and CGP 28238 suggest that NSAID-like toxicity may still be an issue. The promise of selective COX-2 inhibitors remains largely untested. It is with great interest and expectation that the clinical evaluation of the more selective compounds of different structural types is awaited.
Synergistic activation by collagen and 15-hydroxy-9 alpha,11 alpha-peroxidoprosta-5,13-dienoic acid (PGH2) of phosphatidylinositol metabolism and arachidonic acid release in human platelets.
Authors: S E Rittenhouse, C L Allen
Journal: Journal of Clinical Investigation (1982)

Collagen stimulates the activation of phosphatidylinositol (PI)-specific phospholipase C (EC 3.1.4.10) in human platelets, as manifested by the disappearance of PI, the transient formation of diacylglycerol (DG), and release of myoinositol. Platelets exposed to collagen also form lysophosphatidylinositol (LPI). Maximum formation of DG occurs within 60 s of the addition of collagen and is in proportion to the concentration of collagen provided, up to 100 micrograms/2 x 10(9) platelets/ml. Hydrolysis of PI, formation of DG, and release of arachidonic acid are all inhibited approximately 68% by aspirin or indomethacin, both of which inhibit platelet cyclooxygenase. This inhibition is reversed by the product of cyclooxygenase activity, 15-hydroxy - 9 alpha,11 alpha - peroxidoprosta - 5,13 - dienoic acid (PGH2), or by the PGH2 analogue and agonist, U-46619. The counteracting effects of either PGH2 or the PGH2 analogue can be blocked, in turn, by a PGH2 antagonist, U-51605. Neither PGH2 nor its stable analogue is, by itself, an efficient stimulus for PI breakdown to DG and LPI in platelets. However, in conjunction with collagen, these agents synergistically promote the net breakdown of PI and the release of arachidonic acid in aspirin-treated platelets. Our findings thereby imply that PGH2 has an important role in regulating both the release of its precursor, arachidonic acid, and the metabolism of PI induced by collagen. Dibutyryl cyclic AMP or prostaglandin D2 (PGD2), a prostaglandin that elevates concentrations of cAMP in platelets by stimulating adenylate cyclase, inhibits the hydrolysis of PI induced by collagen by 70%. The activation of PI metabolism by collagen appears to be inhibited by cAMP independently of any effects of this inhibitor on the formation of PGH2.
Pain at 12 Months After Surgery for Breast Cancer
Authors: Tuomo J. Meretoja, Marjut H. K. Leidenius, Tiina Tasmuth, Reetta Sipilä, Eija Kalso
Journal: JAMA (2013)

Persistent pain following breast cancer treatments remains a significant clinical problem despite improved treatment strategies.1 Data on factors associated with persistent pain are needed to develop prevention and treatment strategies and to improve the quality of life for breast cancer patients. This prospective study examined the prevalence and severity of and the factors associated with chronic pain after breast cancer surgery and adjuvant treatments.