Shock Caused by Gram-negative Microorganisms
Authors: MAX HARRY WEIL
Journal: Annals of Internal Medicine (1964)

Article1 March 1964Shock Caused by Gram-negative MicroorganismsAnalysis of 169 CasesMAX HARRY WEIL, M.D., F.A.C.P., HERBERT SHUBIN, M.D., F.A.C.P., MARJORIE BIDDLE, PH.D.MAX HARRY WEIL, M.D., F.A.C.P.Search for more papers by this author, HERBERT SHUBIN, M.D., F.A.C.P.Search for more papers by this author, MARJORIE BIDDLE, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-3-384 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA syndrome that is characterized by acute hypotension and shock and occurs during the course of bacteremia due to gram-negative microorganisms was described in 1951 (1, 2). Since then there has been an increasing interest in this entity and in experimental models in which shock is produced in laboratory animals by injection of endotoxin derived from gram-negative bacteria. Initially regarded as a relatively rare occurrence, reports of more than 200 cases in the past decade indicate that this is a common complication in both medical and surgical patients (3-11).In 1958, Spink and one of the present authors (5) reported...References1. WAISBREN BA: Bacteremia due to gram-negative bacilli other than the Salmonella: clinical and therapeutic study. Arch. Intern. Med. (Chicago) 88: 467, 1951. CrossrefGoogle Scholar2. BORDENHALL CWWH: Fatal transfusion reactions from massive bacterial contamination of blood. New Eng. J. Med. 245: 760, 1951. CrossrefMedlineGoogle Scholar3. BRAUDESIEMIENSKIWILLIAMSSANFORD AIJDJP: Overwhelming bacteremic shock produced by gram-negative bacilli: a report of four cases with one recovery. Univ. Mich. Med. Bull. 19: 23, 1953. Google Scholar4. STEVENSLEGGHENRYDILLEKIRBYFINCH ARJSBSJMWMCA: Fatal transfusion reactions from contamination of stored blood by cold growing bacteria. Ann. Intern. Med. 39: 1228, 1953. LinkGoogle Scholar5. 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HARDAWAYBARILLABURNESMOCK RMTGJWHP: Studies on pH changes in endotoxin and hemorrhagic shock. J. Surg. Res. 1: 278, 1961. CrossrefMedlineGoogle Scholar62. WEILUDHOJIALLEN MHVNKS: The head down position in treatment of shock. Surg. Gynec. Obstet. 116: 669, 1963. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MAX HARRY WEIL, M.D., F.A.C.P.; HERBERT SHUBIN, M.D., F.A.C.P.; MARJORIE BIDDLE, PH.D.Affiliations: Los Angeles, CaliforniaFrom the Department of Medicine, University of Southern California School of Medicine and the Los Angeles County Hospital, Los Angeles, California.Supported by the American and the Los Angeles County Heart Associations, by National Heart Institute grant H-5570, and by The John A. Hartford Foundation, Inc., New York.Requests for reprints should be addressed to Max Harry Weil, M.D., Department of Medicine, University of Southern California, School of Medicine, 2025 Zonal Avenue, Los Angeles 90033, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTrauma sepsisOrgan dysfunction during sepsisCecal Ligation and Incision: An Acute Onset Model of Severe Sepsis in RatsClinical sepsisOrgan dysfunction during sepsisTransrectal biopsy of the prostate and bacteraemiaCardiovascular management of septic shockMyocardial dysfunction in the patient with sepsisMyocardial dysfunction in septic shock: Part II. Role of cytokines and nitric oxideMyocardial dysfunction in septic shock: Part I. 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Revisión estadística sobre 490 casosProvidence bacillus bacteremia and septicopyemiaRecovery following prolonged gram-negative shock and “shock lung”The Sympathetic Nervous System and Alpha Adrenergic Blocking Agents in ShockTHE CAUSE OF DEATH FOLLOWING ABORTION. AN ANALYSIS OF 28 CONSECUTIVE CASES AT GROOTE SCHUUR HOSPITALENDOTOXIC SHOCK AND HYPERPYREXIA IN UROLOGICAL PRACTICEEscherichia Coli Meningitis in Adults: Neurosurgical and Neuropathological ConsiderationsThe Chemotherapy of Enterobacterial InfectionsKlinik und Therapie des akuten Nierenversagens unter Berücksichtigung des EndotoxinschocksDeep Electrical Burn Complicated by Anuria and Pseudomonas SepticaemiaIn Vitro Effectiveness of Kanamycin and Kanamycin/Cephalothin Against KlebsiellaComparison with Other AntibioticsROGER J. BULGER, M.D.An essay regarding pathogenesis and treatment of shock due to bacteremia with special reference to “gram-negative” shockClostridium welchii bacteraemia: a case report with survival and review of the literatureHAFNIA: AN UNUSUAL CAUSE OF POSTOPERATIVE GRAM‐NEGATIVE BACTERIÆMIAThe Klebsiella-Enterobacter-Serratia Division Clinical and Epidemiologic CharacteristicsBRUCE W. STEINHAUER, M.D., THEODORE C. EICKHOFF, M.D., JAY WARD KISLAK, M.D., MAXWELL FINLAND, M.D., F.A.C.P.Clinical management of septic abortion complicated by hypotensionGram-Negative Bacteremia: An Evaluation of Fifty-Nine Cases During 1963Bacterial shock in obstetrics and gynecologyThe Treatment of Infections in Patients with Neoplasia Undergoing SurgeryCurrent status of the shock problemRESPIRATORY ACIDOSIS IN BRONCHIAL ASTHMABACTERÆMIC SHOCKGram-negative rod bacteremiaShockTherapy of Infections Caused by Gram-Negative BacilliIntestinal gangrene without apparent vascular occlusionHemodynamic and Metabolic Studies on Shock Associated with Bacteremia Observations on 16 PatientsVASANT N. UDHOJI, M.B., B.S., MAX HARRY WEIL, M.D., PH.D., F.A.C.P. 1 March 1964Volume 60, Issue 3Page: 384-400KeywordsBacteremiaEndotoxinsEscherichia coliGram negative bacteriaHeartHospital medicineHypotensionResearch laboratoriesShockUrinary tract infections ePublished: 1 December 2008 Issue Published: 1 March 1964 PDF downloadLoading ...