tbuckley/cabot-search huggingface dataset:
Widespread Hypermetabolic Lesions Due to Multicentric Form of Castleman Disease as the Cause of Fever of Unknown Origin Revealed by FDG PET/CT
Authors: Yanru Ma, Fang Li, Libo Chen
Journal: Clinical Nuclear Medicine (2013)

A 46-year-old male patient presented with fever for over 5 months. An FDG PET/CT was acquired to evaluate the source of the fever. The images showed many hypermetabolic foci throughout the imaged regions, which mainly corresponded to enlarged lymph nodes. Pathological examination demonstrated that the patient suffered from a multicentric form of Castleman disease.
Assessment of in vivo frequency of mutated T cells in patients with systemic lupus erythematosus.
Authors: F Gmelig-Meyling, S Dawisha, A D Steinberg
Journal: The Journal of Experimental Medicine (1992)

The frequency of mutant T cells (FMC) in blood lymphocytes from patients with systemic lupus erythematosus (SLE) was measured by growing cells in the presence and in the absence of 6-thioguanine. Patients with SLE had a spectrum of FMC ranging from normal to about 100 times normal. This high FMC among cells from SLE patients appears to reflect excessive in vivo activation and proliferation during the course of the disease. This represents the first demonstration of such a T cell abnormality in SLE; it supports the hypothesis that SLE T cells demonstrate increased in vivo division and/or survival.
Use computers to detect inappropriate prescriptions.
Authors: C Valentine
Journal: BMJ (1993)

Child health servicesShould be combined EDITOR,-It is reported in Medicopolitical Digest' that Loretta Light, chairing the community health doctors subcommittee, felt that the guidance in EL(93)28 on implementation of the joint working party report on medical services for children2 does not represent the spirit or the letter of the report and that she was concerned at the advice that community health doctors could help with difficulties in safety net cover in paediatrics.As primary care increases its child health responsibilities and hospital stays shorten with greater home care of sick children, community child health doctors will be undertaking a more specialist role supporting primary care.It is important that they are trained for this wider range of responsibilities.The joint working party agreed that child health doctors should have more experience in hospital paediatrics.Hospital paediatric duties, including on call, could be envisaged for some child health staff grade posts, especially in smaller districts.This proposal is, however, for the future work force and only now for those with appropriate experience or "who are willing to undergo training to work in hospital."
Activities of the Environmental Protection Agency concerning phthalate esters
Authors: Steven D. Newburg-Rinn
Journal: Environmental Health Perspectives (1982)

EPA's activities concerning phthalate esters have been in four general areas, namely: (1) their status as toxic pollutants under the Clean Water Act; (2) their status as "new chemicals" under Section 5 of TSCA; (3) the potential risk to human beings posed by DEHP; and (4) finally, the need for testing phthalates with respect to their health and environmental effects.
SP0084 Reproductive Health and Arthritis: What to Expect
Authors: S. M. Verstappen
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> A number of studies have shown that the symptoms of rheumatoid arthritis (RA) or inflammatory polyarthritis (IP) ameliorate during pregnancy, especially pregnant women who are rheumatoid factor (RF) negative and anti-cyclic citrullinated peptipe antibody (ACPA) negative compared to autoantibody-positive women. Less is known about the influence of pre-symptom or post-symptom onset pregnancies and live births on the long-term disease outcome in women with RA. In addition, the underlying mechanisms of improvement in symptoms during pregnancy and post-partum flare are not disentangled yet, but the role of a number of immunological and hormonal factors have been suggested. The main aim of this talk is to present the influence of pre-symptom pregnancy, pregnancy, post-partum and post-symptom pregnancy on disease activity in patients with RA and IP. <h3>Disclosure of Interest</h3> None Declared
The Specific Heat of Human Blood
Authors: W. F. Lloyd
Journal: BMJ (1897)

moved, with the result that the patients were troubled ever since with ftecal fistula or pericsecal abscess, and on reflecting as to the cause of this untoward result and as to the means of preventing it, it seems to me that the cause of the trouble may be traced to the method employed in these cases of treating the stump of the appendix.When we make an
Provocation of coronary spasm by dopamine in patients with active variant angina pectoris.
Authors: F Crea, S Chierchia, J C Kaski, G J Davies, A Margonato, D O Miran, A Maseri
Journal: Circulation (1986)

The effects of dopamine on arteries are different depending on the dose, route of administration, and receptor population. Its administration can cause vasodilation by stimulation of dopaminergic receptors, vasoconstriction by stimulation of alpha-adrenergic and serotonergic receptors, and even spasm of cerebral arteries when given intracisternally in dogs. The ability of dopamine to provoke coronary spasm was assessed in 18 patients with active vasospastic angina in whom this amine was infused at rates of 5, 10, and 15 micrograms/kg/min for periods of 5 min each. The 12-lead electrocardiogram and blood pressure (cuff) were monitored throughout the whole test. In nine patients dopamine caused angina and ischemic electrocardiographic changes suggestive of coronary spasm: ST segment elevation in six patients and ST segment depression in the absence of important coronary stenoses in the remaining three. Infusion of dopamine was repeated during coronary angiography in three patients with positive test results: this provoked occlusive coronary spasm with ST segment elevation in two patients and nonocclusive spasm with ST segment depression in the remainder. In conclusion, infusion of dopamine provokes coronary spasm in a sizeable proportion of patients with active vasospastic angina. Its administration may be detrimental in patients susceptible to coronary spasm, such as those with acute myocardial infarction.
Studies on the plasma membrane of normal and psoriatic keratinocytes. 4. Characterization of glycoconjugates
Authors: H. ROELFZEMA, M. BERGERS, P.E.J. ERP, J.M. GOMMANS, P.D. MIER
Journal: British Journal of Dermatology (1981)

A substantial proportion (20-50%) of radioactive sugar incorporated into glycoconjugates by normal human keratinocytes was soluble in chloroform-methanol; using (14C)-galactose as precursor about half of this fraction was neutral lipid. The incorporation of labelled sugars into the lipid fraction was consistently increased in keratinocytes derived from psoriatic lesions. The abnormality in fucose metabolism which we reported previously has been confirmed. In particular we have shown that the molecular weight of fucosylated glycopeptides appears to be abnormally high in the untreated psoriatic lesion, possibly reflecting an increased degree of branching. In psoriatic uninvolved epidermis and in treated psoriatic lesions the situation is reversed, the molecular weight being significantly lower than normal.
Efficacy of an Attachable Subcutaneous Cuff for the Prevention of Intravascular Catheter-Related Infection
Authors: R. H. Flowers
Journal: JAMA (1989)

We performed a randomized controlled trial of an attachable subcutaneous cuff for the prevention of central vascular catheter-related infection among patients receiving intensive care. Catheters were placed percutaneously into new sites with or without a cuff and were dressed with polyantibiotic ointment containing polymyxin, neomycin, and bacitracin. Microbial colonization developed in 34.5% of 29 control and 7.7% of 26 cuffed catheters. Catheter-related bloodstream infection occurred with 13.8% of control vs 0% of cuffed catheters. The cuff was not associated with adverse effects. An unexpectedly large proportion (75%) of catheter infections were due to Candida albicans. This may have been due, in part, to the use of polyantibiotic ointment, as suggested by a pooled analysis of previous trials that demonstrated increased Candida colonization of catheters with the ointment, which is not fungicidal. These data suggest that the cuff can reduce the incidence of catheter-related infection among high-risk patients receiving catheter site care with an antibacterial ointment.
RELATION OF SYPHILIS TO BLASTOMYCETIC DERMATITIS.
Authors: HENRY G. ANTHONY
Journal: JAMA (1901)

Since the discovery of actinomycosis hominis by Israel, in 1878, it has been shown with the aid of microscopic preparations preserved in the laboratories of Europe, that cases of this disease were previously observed and reported as cases of sarcomata; cases of mycetoma have been proven to be caused by actinomycosis; the disease has been found in the brain; it has been observed under the clinical diagnosis, appendicitis; Neisser has reported a case which he at first diagnosed as a papulo-pustular syphilid, but which on further examination proved to be actinomycosis cutis and, lastly, branching forms of the bacillus tuberculosis have been found in the lungs which Hektoen<sup>1</sup>tells us can not be distinguished from actinomycosis pulmonalis. Ever since observing the case which my colleague, Dr. Herzog, and I reported last year as a case of blastomycetic dermatitis engrafted on syphilitic ulcers,<sup>2</sup>I have entertained the opinion that
Xanthogranulomatous Pyelonephritis Characterized on PET/CT
Authors: Christopher A. Swingle, Deborah A. Baumgarten, David M. Schuster
Journal: Clinical Nuclear Medicine (2005)

A 35-year-old black woman was referred for a PET/CT scan to evaluate the malignant potential of retroperitoneal lymphadenopathy seen on a CT scan done at an outside institution. The patient had a history of a left-sided renal staghorn calculus and had a stent placed in the left collecting system after extracorporeal shockwave lithotripsy. She remained febrile despite an extensive course of antibiotics. The PET/CT demonstrated a left kidney with CT findings characteristic for xanthogranulomatous pyelonephritis with abnormal F-18 FDG uptake on PET. The retroperitoneal adenopathy had only mild FDG uptake characteristic for benign inflammation.
Q10-triggered facial vitiligo
Authors: K.U. Schallreuter
Journal: British Journal of Dermatology (2013)

Generation and accumulation of reactive oxygen/nitrogen species in the epidermis of patients with vitiligo has been widely documented. Moreover, semiquinone radical-mediated sensitivity has been shown in blood lymphocytes of these patients.To determine the possible mechanism behind Q10-induced facial vitiligo.This was a clinical assessment supported by in vivo Fourier transform-Raman spectroscopy and repigmentation.Topical Q10 application generated hydrogen peroxide (H2 O2 ) leading in turn to facial vitiligo in susceptible individuals. Proof of the basic result stemmed from reduction of epidermal H2 O2 by using narrowband ultraviolet B-activated propseudocatalase PC-KUS in association with cessation of depigmentation and repigmentation of the lost skin colour.Over-the-counter availability of Q10-containing topical formulations can be harmful to individuals susceptible to vitiligo.
The Mentally Abnormal Offender
Authors: Alexander S. Rogawski
Journal: JAMA (1969)

Mentally abnormal offenders present complex and vexing problems to psychiatrists, legal experts, and administrators of psychiatric and penal institutions. In July 1967 the Ciba Foundation assembled a group of outstanding psychiatrists, psychologists, sociologists, and penologists in search for areas of consensus. Dr. George K. Stürup opened the conference with a lecture, "Will This Man Be Dangerous?" an issue that faces everyone responsible for the mentally disordered offender. Where, how, and how long the delinquent is to be treated hinges on the answer. Clinicians and administrators bear the heavy responsibility to balance the rights and interests of the individual offender against the protection of society, yet there are no solid studies to furnish a scientific basis for the assessment of dangerousness. The 13 papers, each followed by a lively panel discussion, fall under three headings. "Antisocial Behavior and Its Treatment and Care" relates delinquency to schizophrenia, cerebral disease and old age,
93 THE USE OF MYCHOPHENOLATE MOFETIL IS A MAJOR DETERMINANT OF ONE YEAR GRAFT SURVIVAL AFTER LIVER TRANSPLANTATION: RESULTS FROM THE LIVER MATCH PROSPECTIVE STUDY
Authors: M. Angelico, T. Marianelli, L. Caccamo, A. Gasbarrini, C. Gavrila, A. Ricci, A. Nardi
Journal: Journal of Hepatology (2010)
Treatment of hepatitis C. The 2002 French consensus
Authors: D Dhumeaux
Journal: Gut (2003)

Chronic infection by hepatitis C virus (HCV) affects 170 million people worldwide.In European countries the overall prevalence in adults ranges from 1% to 2%, 1 2 and more than five million Europeans are thus infected.The high prevalence of HCV infection, together with the risk of severe complications which include cirrhosis and hepatocellular carcinoma, 3 4 makes this a major public health problem.HCV was discovered more than 10 years ago, and considerable progress has since been made in our knowledge of the virus, its modes of transmission, the natural history of the infection, and also patient management, including specific therapy.Several consensus conferences have been organised in the last five years, in particular the French Association for the Study of the Liver in January
SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis.
Authors: B F Murphy, L Kirszbaum, I D Walker, A J d'Apice
Journal: Journal of Clinical Investigation (1988)

We report herein the isolation and initial characterization of a novel protein, termed SP-40,40, which is present at moderate levels (35-105 micrograms/ml) in normal human serum. SP-40,40 is deposited in the renal glomeruli of patients with glomerulonephritis but is not found in normal glomeruli. The protein is a heterodimeric structure of relative molecular mass 80 kD, both chains of which are of a similar size (40 kD). The amino-terminal sequences of both chains are unrelated to one another and possess no significant homology to any known protein sequence. The tissue distribution of SP-40,40 closely resembles that of the terminal complement components and its physicochemical properties are similar to, but distinct from, those of the S protein of complement. We have identified SP-40,40 in the SC5b-9 complex of complement and have demonstrated incorporation of labeled SP-40,40 into this complex. These data suggest that SP-40,40 is an additional component of SC5b-9.
Food Challenge has a Rapidly Established and Persistent Positive Effect on Quality of Life of Children 0-12 years Irrespective of the Clinical Outcome of the Challenge.
Authors: J.O.B. Hourihane, B.M.J. Flokstra-deBlok, A.E.J. Dubois, R. Kahlon, A. DunnGalvin
Journal: Journal of Allergy and Clinical Immunology (2009)
Public Health Strategies for Western Bangladesh That Address Arsenic, Manganese, Uranium, and Other Toxic Elements in Drinking Water
Authors: Seth H. Frisbie, Erika J. Mitchell, Lawrence J. Mastera, Donald M. Maynard, Ahmad Zaki Yusuf, Mohammad Yusuf Siddiq, Richard Ortega, Richard K. Dunn, David S. Westerman, Thomas Bacquart, Bibudhendra Sarkar
Journal: Environmental Health Perspectives (2008)

More than 60,000,000 Bangladeshis are drinking water with unsafe concentrations of one or more elements.Our aims in this study were to evaluate and improve the drinking water testing and treatment plans for western Bangladesh.We sampled groundwater from four neighborhoods in western Bangladesh to determine the distributions of arsenic, boron, barium, chromium, iron, manganese, molybdenum, nickel, lead, antimony, selenium, uranium, and zinc, and to determine pH.The percentages of tube wells that had concentrations exceeding World Health Organization (WHO) health-based drinking water guidelines were 78% for Mn, 48% for U, 33% for As, 1% for Pb, 1% for Ni, and 1% for Cr. Individual tube wells often had unsafe concentrations of both Mn and As or both Mn and U. They seldom had unsafe concentrations of both As and U.These results suggest that the ongoing program of identifying safe drinking water supplies by testing every tube well for As only will not ensure safe concentrations of Mn, U, Pb, Ni, Cr, and possibly other elements. To maximize efficiency, drinking water testing in Bangladesh should be completed in three steps: 1) all tube wells must be sampled and tested for As; 2) if a sample meets the WHO guideline for As, then it should be retested for Mn and U; 3) if a sample meets the WHO guidelines for As, Mn, and U, then it should be retested for B, Ba, Cr, Mo, Ni, and Pb. All safe tube wells should be considered for use as public drinking water supplies.
Organisation of antenatal care.
Authors: W Savage, R Cochrane, S Pathasundaram
Journal: BMJ (1991)

miscarriage, of whom 12 said that they would like to have been shown the products of conception even if no fetus could be identified.The desire to see he fetus or products was not related to the patients' age, parity, marital status, gestation, or planning of the pregnancy.These results indicated that one third of patients would like to be offered the opportunity of seeing the fetus after a spontaneous miscarriage.Whether such a measure would help the patient to grieve remains to be determined.In the absence of scientific proof, however, there is a strong case for acceding to the wishes of the parents if they ask to see the fetus after a spontaneous miscarriage.Miscarriage is the commonest complication of pregnancy, but we still have much to learn about the best way to help couples to come to terms with their loss.
Biliary Tract Strictures after Orthotopic Liver Transplantation: Diagnosis and Management
Authors: L. Theilmann, B. Küppers, M. Kadmon, T. Roeren, H. Notheisen, A. Stiehl, G. Otto
Journal: Endoscopy (1994)

Biliary tract complications in 105 patients who had undergone orthotopic liver transplantation were reviewed in order to determine their incidence and localization. In addition, the possible endoscopic and percutaneous management of such complications was evaluated. Signs of cholestasis appeared in 32 of 105 (30.5%) transplant recipients after a mean of 6.5 months (range 1-19 months), and visualization of the biliary system was performed in all. Twenty biliary tract complications were observed in these 32 patients (62.5%). There were multiple strictures, both intrahepatic and extrahepatic, in 11 grafts. Five of the nine extrahepatic strictures were not confined to the site of the bile duct anastomosis, and involved the whole common bile duct of the donor liver, while the remaining four were confined. The multiple intrahepatic and extrahepatic strictures were related either to occlusion of the hepatic artery or to the fact that the graft had been in a cold ischemic state for a prolonged time. In contrast, multiple strictures and necrosis of the whole extrahepatic bile duct were attributed to local ischemia due to the harvesting procedure. Stenoses strictly confined to the site of anastomosis were thought to be due to surgical technique. Ten extrahepatic bile duct stenoses with considerably impaired bile flow were corrected endoscopically (four), percutaneously (three) and by surgery (three). In four patients with complications in the whole intrahepatic and extrahepatic system, retransplantation was necessary. Biliary tract complications in our patients occurred in up to 19% after liver transplantation on long-term follow-up. Complications of only the extrahepatic system can be treated successfully, whereas complications involving multiple stenoses of the intrahepatic bile duct system frequently require retransplantation.
CEREBROSPINAL FLUID OF ANOMALOUS CHARACTER IN A CASE OF INTRASPINAL TUMOR
Authors: C. M. COOPER
Journal: JAMA (1910)

eye.behind the spectacle glass.He was now allowed to sit up..lunel!l one drop of solution of atropin was instilled into each eye, and June 2-1 the instillation of the solution of atropin info the left eye was discontinued.
Viral hepatitis: Biological and clinical features, specific diagnosis, and prophylaxis. 2nd ed. By F.B. Hollinger, W.S. Robinson, R.H. Purcell, J.L. Gerin and J. Ticehurst, 204 pp. New York: Raven Press, 1990. $78
Authors: Raymond S. Koff
Journal: Hepatology (1991)
The combined influence of the stimulus frequency of the vagal nerves and the atrial stimulus interval on the atrioventricular conduction time
Authors: E. L. DE BEER, H. B. K. BOOM, B. NAAFS
Journal: Cardiovascular Research (1977)

The way in which the A-V node adapts its conduction time to stepwise alterations of atrial stimulation rates was studied under different conditions of vagal nerve activity (open chest, anaesthetised rabbit). Increase of stimulation rate induced oscillatory adaptation to a longer conduction time. Decrease caused shorter conduction times without oscillation. The time constant did not differ. Oscillation amplitude and time constants were markedly influenced by vagal activity. The observed phenomena can be explained on the basis of a time and voltage dependent K+ conductance.
One year Clinical, Angiographic, and Optical Coherence Tomography Outcomes of 2nd Generation Drug Eluting Stents 6 Months Dual Antiplatelet Therapy Between Biodegradable and Durable Polymer Stent
Authors: Byoung Kwon Lee, Young Won Yoon, PIl-Ki Min, Bum-Kee Hong, Hyuck Moon Kwon, Byeong Keuk Kim, Myeong-Ki Hong, Yangsoo Jang
Journal: Journal of the American College of Cardiology (2014)
Psychological Stress and the Onset of IDDM in Children: A case-control study
Authors: Gunilla M Thernlund, Gisela Dahlquist, Kjell Hansson, Sten A Ivarsson, Johnny Ludvigsson, Sture Sjöblad, Bruno Hägglöf
Journal: Diabetes Care (1995)

OBJECTIVE The purpose of the study was to determine whether psychosocial stress during different life periods could be a risk factor in the etiology/pathogenesis of insulin-dependent diabetes mellitus (IDDM) in children. RESEARCH DESIGN AND METHODS In a population-based sample of 67 case patients 0–14 years of age and 61 matched healthy control subjects, life events during the entire lifespan before the onset of IDDM were recorded as well as measures of child behavior before onset, social support, and family function. RESULTS Negative life events occurring during the first 2 years of life, life events with difficult adaptation, child behavioral deviances, and a more chaotic family function were more common in the case group. A stepwise logistic regression indicated that negative life events in the first 2 years increased the risk of IDDM and that premorbid child behavior as well as dysfunctional hierarchical family pattern affect the risk. CONCLUSIONS Stress early in life may increase the risk for IDDM, presumably by affecting the autoimmune process. To confirm these results, it is necessary to make a truly prospective study.
Relation of Negative Intraventricular Pressure to Ventricular Volume
Authors: GERHARD A. BRECHER, ABBOTT T. KISSEN
Journal: Circulation Research (1957)

Elastic forces of the ventricular walls produce a subatmospheric (negative transmural) pressure in the empty quiescent ventricle of open chest dogs. As fluid is added to the ventricle the negative intraventricular trausmural pressures become 0 and finally positive. The resulting ventricular pressure-volume curves are S-shaped, having one limb in the negative and another in the positive pressure range. It is concluded that previously reported suction and negative intraventricular transmural pressures lasting throughout the entire diastole in ventricles with small residual volumes are caused by elastic forces which also prevail under static conditions.