tbuckley/cabot-search huggingface dataset:
Antiandrogen Bicalutamide Promotes Tumor Growth in a Novel Androgen-Dependent Prostate Cancer Xenograft Model Derived from a Bicalutamide-Treated Patient
Authors: Toru Yoshida, Hidefumi Kinoshita, Takehiko Segawa, Eijiro Nakamura, Takahiro Inoue, Yousuke Shimizu, Toshiyuki Kamoto, Osamu Ogawa
Journal: Cancer Research (2005)

Abstract Androgen ablation therapies are effective in controlling prostate cancer. Although most cancers relapse and progress despite androgen ablation, some patients experience antiandrogen withdrawal syndrome, in which those treated with antiandrogen show clinical improvement when antiandrogen is discontinued. Although the androgen receptor (AR) is suggested to play an important role in prostate cancer progression even after the androgen ablation, limited tissue availability for molecular studies and small numbers of human prostate cancer cell lines have restricted prostate cancer research. Here, we describe KUCaP, a novel serially transplantable human prostate cancer xenograft model. We established KUCaP from liver metastatic tissue of a patient treated with antiandrogen bicalutamide. KUCaP expressed the AR with a point mutation at amino acid 741 (tryptophan to cysteine; W741C) in the ligand-binding domain. This mutation was also present in cancerous tissue used for generation of KUCaP. Although the growth of KUCaP in male mice was androgen dependent, bicalutamide aberrantly promoted the growth and prostate-specific antigen production of KUCaP. For the first time, we show the agonistic effect of bicalutamide to a xenograft with clinically induced AR mutation. This bicalutamide-responsive mutant AR will serve in the development of new therapies for androgen ablation–resistant prostate cancers.
National Study of Internal Medicine Manpower: III. Subspecialty Fellowship Training 1976-1977
Authors: ALVIN R. TARLOV
Journal: Annals of Internal Medicine (1979)

Questionnaire II of the National Study of Internal Medicine Manpower was directed to all of the 1502 subspecialty training programs in the United States and Puerto Rico. The overall response rate was 86%. For the years 1972-1973 through 1976-1977 the number of fellows in subspecialty training grew at an average rate of 10.6% per year, or one and one-half times greater than the growth rate of 7.2% in the number of first-year residents in training for the same time period. In 1976-1977 there were 5826 fellows in subspecialty fellowship training, of whom 26% were foreign medical graduates. Stipends for subspecialty fellows in 1976-1977 amounted to $90 million, 40% of which was derived from direct federal funds and 33% from hospital revenues. Most of the subspecialty fellowship programs were in large teaching hospitals, which are closely affiliated with the nation's medical schools. The 1976-1977 professional activities of former subspecialty trainees who had finished their training between 1972 and 1976 were distributed roughly in thirds between research-teaching, teaching-practice, and practice. We discuss public policy implications of the data.
Pseudoeventration of Right Diaphragm
Authors: Stanley F. Reich
Journal: JAMA (1979)

<h3>History</h3> A 70-year-old man gave a history of shortness of breath, which had become worse in the week before admission. He had had cyanosis for three weeks. He had been treated for active pulmonary tuberculosis with chemotherapy in 1969. His blood pressure was 130/100 mm Hg; respirations, 44/min. He had venous distension of the neck but no murmurs or gallop rhythm. There were rales at both bases with diminished breath sounds at the right base. His extremities were cyanotic and cool. The admission posteroanterior and lateral teleroentgenograms are shown in Fig 1 and 2. <h3>Diagnosis</h3> Subpulmonic effusion. <h3>Comment</h3> Figure 1 shows what seems to be a lobulated elevation of the right hemidiaphragm. It extends to the level of the eighth posterior rib. There is slight blunting of the right costophrenic sulcus. Residual tuberculosis is seen in the right upper lobe. The heart is enlarged. Figure 2 shows blunting of the
The oligodendrocyte-specific G protein–coupled receptor GPR17 is a cell-intrinsic timer of myelination
Authors: Ying Chen, Heng Wu, Shuzong Wang, Hisami Koito, Jianrong Li, Feng Ye, Jenny Hoang, Sabine S Escobar, Alexander Gow, Heather A Arnett, Bruce D Trapp, Nitin J Karandikar, Jenny Hsieh, Q Richard Lu
Journal: Nature Neuroscience (2009)
Lytic bone metastases after APD in breast carcinoma: Authors' reply
Authors: A Howell, D J Dodwell
Journal: BMJ (1988)

and not be limited to conventions.Classical power determination does use a single alternative hypothesis, but power of the test is even greater if the true difference is larger than the posited clinically important difference.We think that Bayesian approaches offer great potential.As presently developed, however, the Bayesian method is difficult even for Bayesian statisticians and requires more research before it becomes practical.Development of Bayesian in- ference instruments that are easily employed by clinicians would greatly advance the usefulness of the Bayesian approach.
Late Outcomes of a Single-Center Experience of 400 Consecutive Thoracic Endovascular Aortic Repairs
Authors: W. Anthony Lee, Michael J. Daniels, Thomas M. Beaver, Charles T. Klodell, Dan E. Raghinaru, Philip J. Hess
Journal: Circulation (2011)

In this study, we report the late outcomes of a large, decade-long single-center thoracic endovascular aortic repair experience.A prospectively maintained registry and the electronic medical records of 400 consecutive thoracic endovascular aortic repair performed at a tertiary care center were reviewed. The distribution of pathologies treated included aneurysms (198, 49%), dissections (100, 25%), penetrating ulcers (54, 14%), traumatic transections (25, 6%), and other pathologies (23, 6%). Spinal drains were placed prophylactically in 127 cases (32%) of planned extended aortic coverage. There were no acute surgical conversions. Adjunctive surgical procedures were performed on 94 patients (24%). Subclavian revascularizations were performed selectively in only 15% of zone 0 to 2 deployments. The median length of stay was 5 days (limits, 1 and 79 days). Overall 30-day mortality was 6.5% (elective, 2.6%; urgent, 9.5%; and emergent, 20%). Permanent spinal cord ischemia occurred in 4.5% and stroke in 3%. Kaplan-Meier estimates of survival were 82%, 76%, 68%, and 60% and freedom from secondary intervention was 90%, 86%, 81%, and 78% at 6, 12, 24, and 36 months, respectively. Risk factors for mortality included stroke, urgent/emergent repair, age ≥80 years, general anesthesia, and dissection pathology.Thoracic endovascular aortic repair may be used to treat a variety of thoracic aortic pathologies with a very low risk of intraoperative conversion. Overall rates of mortality and neurological complications were relatively low but significantly increased in emergent repairs. There appeared to be a substantial number of late deaths, which may represent a combination of poor patient selection and treatment failures.
Follicular Lymphoma in the United States: First Report of the National LymphoCare Study
Authors: Jonathan W. Friedberg, Michael D. Taylor, James R. Cerhan, Christopher R. Flowers, Hildy Dillon, Charles M. Farber, Eric S. Rogers, John D. Hainsworth, Elaine K. Wong, Julie M. Vose, Andrew D. Zelenetz, Brian K. Link
Journal: Journal of Clinical Oncology (2009)

Purpose Optimal therapy of follicular lymphoma (FL) is not defined. We analyzed a large prospective cohort study to identify current demographics and patterns of care of FL in the United States. Patients and Methods The National LymphoCare Study is a multicenter, longitudinal, observational study designed to collect information on treatment regimens and outcomes for patients with newly diagnosed FL in the United States. Patients were enrolled between 2004 and 2007. There is no study-specific prescribed treatment regimen or intervention. Results Two thousand seven hundred twenty-eight subjects were enrolled at 265 sites, including the 80% of patients enrolled from nonacademic sites. Using the Follicular Lymphoma International Prognostic Index (FLIPI), three distinct groups independent of histologic grade could be defined. Initial therapeutic strategy was: observation, 17.7%; rituximab monotherapy, 13.9%; clinical trial 6.1%; radiation therapy, 5.6%; chemotherapy only, 3.2%; chemotherapy plus rituximab, 51.9%. Chemotherapy plus rituximab regimens were: rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone, 55.0%; rituximab plus cyclophosphamide, vincristine, and prednisone, 23.1%; rituximab plus fludarabine based, 15.5%; other, 6.4%. The choice to initiate therapy rather than observe was associated with age, FLIPI, stage, and grade (P &lt; .01). Significant differences in treatment (P &lt; .01) across regions of the United States were noted. Contrary to practice guidelines, treatment of stage I FL frequently omits radiation therapy. Conclusion Widely disparate therapeutic approaches are utilized for FL. Initial therapy is deferred in a small subset of patients. There is no single standard of care for the treatment of de novo FL, although antibody use is ubiquitous when therapy is initiated. These disparate approaches to the initial care of patients with FL render a heterogeneous group of patients at relapse.
P207 Can Holistic Interventions Improve the Care of People with Severe Chronic Obstructive Pulmonary Disease (COPD)? A Systematic Review
Authors: UB Nurmatov, S Buckingham, M Kendall, A Sheikh, H Pinnock
Journal: Thorax (2012)

<h3>Introduction and Objectives</h3> People with severe COPD have a long-recognised burden of disabling physical symptoms compounded by co-morbidity, psychological distress and social isolation. We aimed to review the effectiveness of interventions designed to deliver holistic care compared to usual care for people with severe COPD. <h3>Methods</h3> We searched 11 international electronic databases, three trial repositories and contacted a panel of international experts to locate published, unpublished and in-progress randomised controlled trials (RCTs), quasi-RCTs and controlled clinical trials (CCTs) that investigated holistic interventions designed to support patients with severe COPD in any healthcare context. Date range January 1990–March 2012; no language or geographical restrictions. Quality assessment and data extraction followed the Cochrane Collaboration method. Health-related quality of life (HRQoL) was the primary outcome. We used a piloted data extraction sheet and undertook narrative synthesis. <h3>Results</h3> From 2,866 potentially relevant papers, three trials met our inclusion criteria: two RCTs (from United States and Australia), and one CCT (from Thailand) studying a total of 216 patients. Critical appraisal identified a moderate (one RCT and the CCT) or high (one RCT) risk of bias. All interventions were led by nurses acting in a co-ordinating role (e.g. facilitating community support in Thailand, providing case-management in the US, or co-ordinating inpatient care in Australia). The community-based intervention in Thailand significantly improved HRQoL at three months compared to (limited) usual care (St George’s Respiratory Questionnaire: intervention: 30.3±19.4 vs control 52.4±21.3 p&lt;0.001). Significant effects in the US trial were confined to ‘Physical functioning’ and ‘General health’ sub-domains of Medical Outcomes Study Short-Form-36 at three but not six-months. There were no significant changes in the Australian trial. <h3>Conclusions</h3> Some 15 years after reports first highlighted the substantial unmet needs of people with severe COPD, we have been unable to find robust trial evidence about interventions to address those needs. There is an urgent need to develop and evaluate interventions to deliver or enhance holistic care and improve the quality of life of people with severe COPD. <h3>Funding</h3> Dunhill Medical Trust. HP is supported by a PCRCA Fellowship (CSO, Scottish Government).
Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration
Authors: Yali Jia, Steven T. Bailey, David J. Wilson, Ou Tan, Michael L. Klein, Christina J. Flaxel, Benjamin Potsaid, Jonathan J. Liu, Chen D. Lu, Martin F. Kraus, James G. Fujimoto, David Huang
Journal: Ophthalmology (2014)
Osteopathy, Chiropractic, and Spinal Manipulation
Authors: Paul G. Shekelle
Journal: Annals of Internal Medicine (1993)

Letters15 April 1993Osteopathy, Chiropractic, and Spinal ManipulationPaul G. Shekelle, MD, Robert H. Brook, MD, and Alan H. Adams, MDPaul G. Shekelle, MDSearch for more papers by this author, Robert H. Brook, MDSearch for more papers by this author, and Alan H. Adams, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-8-199304150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The four letters blur the difference between spinal manipulation, a procedure practiced by chiropractors, medical physicians, osteopaths, physical therapists, and perhaps others, and the practice of chiropractic or osteopathy. These issues are related but distinct; our review, however, dealt primarily with spinal manipulation.Dr. Plaugher believes that there is a difference in the efficacy of different techniques of manipulation and cites the study of Meade and colleagues [1]. The authors, however, drew no such conclusion. No well-conducted, randomized, controlled trials have been done comparing different techniques of manipulation for patients with low-back pain. We do not state that ...References1. Meade TW, Dyer S, Browne W, Townsend J, Frank AO. Low back pain of mechanical origin: randomised comparison of chiropractic and outpatient treatment. BMJ. 1990; 300:1431-7. Google Scholar2. Shekelle PG, Adams AH, Chassin MR, Hurwitz EL, Park RE, Phillips RB, et al. The appropriateness of spinal manipulation for low-back pain: indications and ratings by a multi-disciplinary expert panel. R-4025/2-CCR/FCER. Santa Monica, California: RAND; 1991. Google Scholar3. Koes BW, Assendelft WJ, van der Heijden GJ, Bouter LM, Knipschild PG. Spinal manipulation and mobilisation for back and neck pain: a blinded review. BMJ. 1991; 303:1298-303. Google Scholar4. Anderson R, Meeker WC, Wirick BE, Mootz RD, Kirk DH, Adams A. A meta-analysis of clinical trials of spinal manipulation. J Manipulative Physiol Ther. 1992; 15:181-94. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1993Volume 118, Issue 8Page: 651-653KeywordsChiropracticOsteopathySciatic nerves ePublished: 15 August 2000 Issue Published: 15 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P71 LEUKAEMIA INHIBITORY FACTOR PROTECTS CHOLANGIOCARCINOMA CELLS FROM CYTOTOXICITY VIA A STAT-3-INDEPENDENT, Mcl-1 ACTIVATION
Authors: M. Cadamuro, S.D. Morton, S. Brivio, T. Stecca, M. Massani, N. Bassi, A. Floreani, M. Strazzabosco, L. Fabris
Journal: Journal of Hepatology (2014)
A BEDSIDE BOTTLE HOLDER
Authors: Everett E. Angle
Journal: JAMA (1924)

This holder is simply made and simple in its action, yet it has filled a want at the James Buchanan Brady Foundation for Urology at the New York Hospital. The holder hooks onto the side of the bed and disappears under it. A 2 liter bottle is thus held well under the bed where it cannot possibly be hit by any one passing or standing beside the bed. The bottle, while held safely out of the way, is still accessible when it needs to be emptied or when one wishes to observe the amount or character of its contents. The holder is constructed with a wide steel band that is so bent as to hook over the rail of the bed and then curve back under the bed before forming the floor of the rack. One hoop is sufficient to hold the bottle in place, and allows it to be
Studies on the in vitro and in vivo expression of a dysfunctional α‐ globin gene
Authors: Surinder Safaya, David R. Trauber, Ronald F. Rieder
Journal: American Journal of Hematology (1992)

In a black family with members having alpha-thalassemia and hemoglobin H (HbH) disease, a deletion of an AG dinucleotide at the 3' end of exon 1 near the junction with intron 1 was shown previously to produce a dysfunctional alpha-thalassemia gene with a reading frame-shift and a nonsense codon (Safaya S, Rieder RF: J Biol Chem 263:4328-4332, 1988). We have found that the same mutation is responsible for alpha-thalassemia and HbH disease in a second unrelated black family (Bellevue R, Dosik H, Rieder RF: Br J Haematol 41:193-202, 1979). Despite the loss of two nucleotides from the consensus sequence at the 5' splice donor site of intron 1, studies employing an in vitro plasmid-based expression system indicated that the mutant alpha-globin mRNA was spliced normally and expressed in amounts equal to normal alpha-globin mRNA in COS-7 cells. The correct processing of the mRNA in these studies is probably due to the presence of a tandem repeat of the affected AG dinucleotide. However, in reticulocytes from subjects bearing the mutant gene, we were unable to detect any of the abnormal mRNA. These findings suggest that there is accelerated post-transcriptional loss of mRNA bearing a premature terminator codon.
Music related upper limb pain in schoolchildren.
Authors: H J Fry, G L Rowley
Journal: Annals of the Rheumatic Diseases (1989)

Two British secondary schools (one a specialist music school) were surveyed to assess the prevalence of upper limb pain among specialist music students compared with students in a regular school setting. Female students tended to report pain more often than male students, but for both significantly higher prevalence was found in the music school. Pain in the regular school was most often attributed to writing, whereas in the music school it was associated with the playing of all instruments, but most particularly with cello, clarinet, and flute. Music students reported long hours of practice, but it appeared that the intensity of practice may be more important as a determinant of pain than the total hours spent practising. The results of the study are in substantial agreement with those previously published from Australia and North America. On the balance of probabilities the pain is due to overuse syndrome, which is very common in musicians and well known in writers.
Does Histocompatibility Affect Homograft Valve Function After the Ross Procedure?
Authors: J.F. Matthias Bechtel, Claus Bartels, Claudia Schmidtke, Wim Skibba, Michael Müller-Steinhardt, Harald Klüter, Hans-Hinrich Sievers
Journal: Circulation (2001)

Homograft valves have been shown to be immunogenic, but it is unknown whether this affects valve function. Therefore, we prospectively studied the degree of histoincompatibility (defined as the number of human leukocyte antigen [HLA] mismatches between valve donor and recipient) and the response of the recipient (measured by antibodies against HLA) in relation to echocardiographic parameters of homograft valve function after the Ross procedure.Twenty-six patients (mean age 41+/-14 years; 20 males, 6 females) and the cryopreserved pulmonary homograft valves that were implanted during a Ross procedure were typed for HLA-A, HLA-B, and HLA-DR. After a mean follow-up of 15+/-6 months, 14 (54%) of the patients were anti-HLA class I antibody positive. In all but 1 patient, these antibodies were shown to be donor specific. During follow-up, there was a significant increase of the maximal (+6.2+/-7.1 mm Hg) and mean (+3.2+/-4.3 mm Hg) transhomograft pressure gradients but not of homograft regurgitation. Neither the number of HLA mismatches nor antibody status was found to have significant impact on homograft valve function. In a multivariate analysis, smaller homograft size (P=0.001) and younger recipient age (P=0.044) were shown to be significantly associated with increased transhomograft pressure gradients.Implantation of a cryopreserved pulmonary homograft during the Ross procedure can induce a specific humoral response. We observed a significant increase of the transhomograft pressure gradients within 15+/-6 months after surgery. For this period, we were unable to demonstrate a relationship between this increase and the degree of histoincompatibility.
Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes
Authors: Florence E. Roufosse, Jean-Emmanuel Kahn, Gerald J. Gleich, Lawrence B. Schwartz, Anish D. Singh, Lanny J. Rosenwasser, Judah A. Denburg, Johannes Ring, Marc E. Rothenberg, Javed Sheikh, Ann E. Haig, Stephen A. Mallett, Deborah N. Templeton, Hector G. Ortega, Amy D. Klion
Journal: Journal of Allergy and Clinical Immunology (2012)
Hematological malignancy in hemoglobin D disease
Authors: Sumitra Dash, Sudarshan Kumar, Radharaman J. Dash
Journal: American Journal of Hematology (1988)

American Journal of HematologyVolume 27, Issue 4 p. 305-305 Letter to the EditorFree Access Hematological malignancy in hemoglobin D disease Sumitra Dash, Sumitra Dash Department of Haematology and Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh, IndiaSearch for more papers by this authorSudarshan Kumar, Sudarshan Kumar Department of Haematology and Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh, IndiaSearch for more papers by this authorRadharaman J. Dash, Radharaman J. Dash Department of Haematology and Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh, IndiaSearch for more papers by this author Sumitra Dash, Sumitra Dash Department of Haematology and Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh, IndiaSearch for more papers by this authorSudarshan Kumar, Sudarshan Kumar Department of Haematology and Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh, IndiaSearch for more papers by this authorRadharaman J. Dash, Radharaman J. Dash Department of Haematology and Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh, IndiaSearch for more papers by this author First published: April 1988 https://doi.org/10.1002/ajh.2830270416Citations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume27, Issue4April 1988Pages 305-305 ReferencesRelatedInformation
Localization of Tc-99m MDP in Cystosarcoma Phyllodes
Authors: SUSAN HOBBS, RONALD D. NEUMANN, MARIA J. MERINO, JEFF GUNZENHAUSER, JORGE A. CARRASQUILLO
Journal: Clinical Nuclear Medicine (1992)

This report describes two cases of Tc-99m MDP uptake in metastatic lesions to the lungs and soft tissues from cystosarcoma phyllodes (CP). Although CP is an infrequent tumor, it is the most common malignant fibroepithelial tumor of the breast. Uptake of bone agents has been reported in primary CP. The uptake in these patients was unique in that it occurred in metastatic sites. Histologically, CP can exhibit the cartilaginous or osseous metaplasia most likely responsible for the localization observed. Thus, these cases raise awareness about the soft-tissue accumulation of bone agents in cystosarcoma phyllodes.