Interaction of Fluconazole and Cyclosporine
Authors: Alan M. Sugar
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 May 1989Interaction of Fluconazole and CyclosporineAlan M. Sugar, MD, Carol Saunders, RN, Beldon A. Idelson, MD, David B. Bernard, MDAlan M. Sugar, MD, Carol Saunders, RN, Beldon A. Idelson, MD, David B. Bernard, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-10-844_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Fluconazole is a new azole orally administered antifungal agent with a broad spectrum of activity (1). This drug may prove useful in treating infections due to Candida and other fungal pathogens common in organ transplantation recipients. We feel it is important to identify any interaction between fluconazole and cyclosporine, because ketoconazole, a closely related antifungal, has been reported to increase serum concentrations of cyclosporine to potentially toxic levels (2-4), and similar interactions may occur with another new azole antifungal, itraconazole (5).A 46-year-old diabetic woman received a kidney donated by a living relative 15 months before admission....References1. Saag M and Dismukes W. Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother. 1988;32:1-8. CrossrefMedlineGoogle Scholar2. Ferguson R, Sutherland D, Simmons R, and Najarian J. Ketoconazole, cyclosporine metabolism, and renal transplantation. Lancet. 1982;2:882-3. CrossrefMedlineGoogle Scholar3. Dierperink H and Moller J. Ketoconazole and cyclosporine. Lancet. 1982;2:1217. CrossrefGoogle Scholar4. White D, Blatchford N, and Cauwenberg G. Cyclosporine and ketoconazole. Transplantation. 1984;37:214-5. CrossrefMedlineGoogle Scholar5. Kwan J, Foxall P, Davidson D, Bending M, and Eisinger A. Interaction of cyclosporin and itraconazole. Lancet. 1987;2:282. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Alan M. Sugar, MD; Carol Saunders, RN; Beldon A. Idelson, MD; David B. Bernard, MDAffiliations: Boston University Medical Center Boston, MA 02118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImpact of Low-Dose Fluconazole on Tacrolimus Dosing in Renal TransplantClinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi StudyEvaluation of the effect of fluconazole on the pharmacokinetics of cyclosporin A in healthy dogs after a single dose and at steady-stateFluconazoleManagement of Drug and Food Interactions with Azole Antifungal Agents in Transplant RecipientsDrug Interactions Involving Antifungal Drugs: Time Course and Clinical SignificanceANTIFUNGAL DRUGSPharmacology of Azole Antifungal AgentsFluconazoleRisk factors for fungal infection in paediatric liver transplant recipientsDrug interactions in the hematopoietic stem cell transplant (HSCT) recipient: what every transplanter needs to knowEffect of Fluconazole on the Pharmacokinetics and Pharmacodynamics of Oral and Rectal Bromazepam: An Application of Electroencephalography as the Pharmacodynamic MethodApproach Towards Infectious Pulmonary Complications in Lung Transplant RecipientsAntifungal prophylaxis and therapy: controversies and emerging issuesPharmacokinetic Aspects of Treating Infections in the Intensive Care UnitEffects of the Antifungal Agents on Oxidative Drug MetabolismDrug interactions with itraconazole, fluconazole, and terbinafine and their managementMETABOLISM-BASED DRUG INTERACTIONS INVOLVING ORAL AZOLE ANTIFUNGALS IN HUMANS*Antifungal Agents. 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Chugh, MDFluconazole: A New Triazole Antifungal AgentINTERACTION BETWEEN FLUCONAZOLE AND CYCLOSPORINInfection in Relation to Thoracic Transplantation 15 May 1989Volume 110, Issue 10Page: 844-844KeywordsAntifungalsAttentionCandidaDrugsFungal pathogensKidneysOrgan transplantation ePublished: 1 December 2008 Issue Published: 15 May 1989 PDF downloadLoading ...