tbuckley/cabot-search huggingface dataset:
Beta-adrenergic blocking drugs may exacerbate vitiligo
Authors: K.U. Schallreuter
Journal: British Journal of Dermatology (1995)

Journal Article Beta‐adrenergic blocking drugs may exacerbate vitiligo Get access K.U. Schallreuter K.U. Schallreuter Department of Dermatology, University of Hamburg, Martinistr 52, 20246 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 1, 1 January 1995, Pages 168–169, https://doi.org/10.1111/j.1365-2133.1995.tb08660.x Published: 01 January 1995
The association of diabetes specialist care with health care practices and glycemic control in patients with type 1 diabetes: a cross-sectional analysis from the Pittsburgh epidemiology of diabetes complications study.
Authors: J C Zgibor, T J Songer, S F Kelsey, J Weissfeld, A L Drash, D Becker, T J Orchard
Journal: Diabetes Care (2000)

OBJECTIVE: To determine whether diabetes care characteristics and glycemic control differ by use of specialist care in a representative cohort of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: Health care, sociodemographic characteristics, and glycemic control were compared between participants in the Pittsburgh Epidemiology of Diabetes Complications Study who reported receiving specialist care (n = 212) and those who did not (n = 217). Specialist care was defined as having received care from an endocrinologist or diabetologist or diabetes clinic attendance during the last year. RESULTS: Patients who reported receiving specialist care were more likely to be female, to have an education level beyond high school, to have an annual household income &amp;gt;$20,000, and to have health insurance. Additionally, patients receiving specialist care were more likely to have received diabetes education during the previous 3 years, to have knowledge of HbAlc testing and to have received that test during the previous 6 months, to have knowledge of the Diabetes Control and Complications Trial results, to self-monitor blood glucose, and to inject insulin more than twice daily. A lower HbA1 level was associated with specialist care versus generalist care (9.7 vs. 10.3%; P = 0.0006) as were higher education and income levels. Multivariate analyses suggest that the lower HbA1 levels observed in patients receiving specialist care were restricted to patients with an annual income &amp;gt;$20,000. CONCLUSIONS: Specialist care was associated with higher levels of participation in diabetes self-care practices and a lower HbA1 level. Future efforts should research and address the failure of patients with low incomes to benefit from specialist care.
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
Authors: Nina Schönhuber, Barbara Seidler, Kathleen Schuck, Christian Veltkamp, Christina Schachtler, Magdalena Zukowska, Stefan Eser, Thorsten B Feyerabend, Mariel C Paul, Philipp Eser, Sabine Klein, Andrew M Lowy, Ruby Banerjee, Fangtang Yang, Chang-Lung Lee, Everett J Moding, David G Kirsch, Angelika Scheideler, Dario R Alessi, Ignacio Varela, Allan Bradley, Alexander Kind, Angelika E Schnieke, Hans-Reimer Rodewald, Roland Rad, Roland M Schmid, Günter Schneider, Dieter Saur
Journal: Nature Medicine (2014)
Evaluation of mixed exposure to carcinogens and correlations of in vivo and in vitro systems.
Authors: U Saffiotti
Journal: Environmental Health Perspectives (1983)

The biological evaluation of air pollutants is an example of the difficulties of evaluating the effects of mixed concurrent exposures to multiple agents, such as combinations of carcinogens with other carcinogens of the same or different chemical class, with incomplete carcinogens and cocarcinogens, with particulate materials and other factors that modify tissue distribution and retention, and with modifiers of metabolic pathways of activation and detoxication. A research approach is outlined to investigate such interactions in a series of biological systems of increasing complexity but closely related to each other in a step-by-step sequence, e.g., bacterial mutagenesis; mammalian cell mutagenesis, toxicity and neoplastic transformation, including embryo cells, fibroblasts and epithelial cells; organ cultures of target epithelia; in vivo animal systems for short-term and long-term studies, including animal models closely comparable to human pathology; observational studies of human pathology and histopathogenesis; experimental studies of corresponding human target tissues using organ and cell culture methods for metabolism, toxicity, mutagenicity and possibly neoplastic cell transformation. Respiratory carcinogenesis models were successfully used for studies of mixed exposures to different carcinogens and cofactors. The role of particulates has been found to be important but needs to be further characterized. Quantitative variations in the response to carcinogens and cofactors among different biological test systems and among different individuals in the human population make quantitative risk estimation very difficult, but studies in a sequence of related biological systems including human tissues indicate the importance of qualitative risk evaluation.
Social Ills and Appetite Pills
Authors: GEORGE VASH
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 October 1971Social Ills and Appetite PillsGEORGE VASH, M.D.GEORGE VASH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-4-645 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Edison's article on amphetamines (Ann Intern Med 74:605-610, 1971) exposes deeply the painful condition of the American physician: he points out that we are "treating with drugs a condition such as obesity, which probably most often has its roots in social custom and psychological conflict."How very true this is, but short of changing the make up of American society, what else can we do? If our society is based on the love of self-deception, on the need to see things as they ought to be rather than as they are, why single out the last... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 206 S. Gilmor St. Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMedical and surgical options in the treatment of severe obesity 1 October 1971Volume 75, Issue 4Page: 645-645KeywordsAmphetaminesDrugsObesity Issue Published: 1 October 1971 PDF DownloadLoading ...
Death toll from malaria is double the WHO estimate, study finds
Authors: A. Gulland
Journal: BMJ (2012)

The World Health Organization has defended its figures on malaria mortality after a study found that the number of deaths from the disease had been seriously underestimated.

In a paper published in the Lancet (doi:10.1016/S0140-6736(12)60034-8) Christopher Murray, director of the Institute for Health Metrics and Evaluation at the University of Washington, Seattle, and colleagues found that in 2010 1.2 million people died from malaria. This is in contrast to WHO’s World Malaria Report , published in December 2011 ( BMJ 2011;343:d8079, doi:10.1136/bmj.d8079), which found that 655 000 people died from the disease in the same year.

The researchers systematically searched for all available published and unpublished data on malaria mortality between 1 January 1980 and 31 December 2010. They found that the …
Primary Care Physician Workforce and Outcomes
Authors: Robert L. Phillips, Stephen C. Petterson, Andrew W. Bazemore
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oncolytic Adenovirus Expressing a p53 Variant Resistant to Degradation by HPV E6 Protein Exhibits Potent and Selective Replication in Cervical Cancer
Authors: Daniëlle A.M. Heideman, Renske D.M. Steenbergen, Jaco van der Torre, Martin Scheffner, Ramon Alemany, Winald R. Gerritsen, Chris J.L.M. Meijer, Peter J.F. Snijders, Victor W. van Beusechem
Journal: Molecular Therapy (2005)

Rationale in the development of novel treatment strategies for HPV-associated cancers is targeting on the basis of the presence of HPV in (pre)malignant cells. Here, we designed a new conditionally replicating adenovirus (CRAd) for selective and effective oncolytic replication in HPV-containing cells. As the backbone, we used the CRAd AdCB016, which replicates selectively in cells expressing HPV E6 and E7 proteins. To enhance its oncolytic potency, we armed AdCB016 with p53 variant mp53(268N), which is resistant to HPV E6-mediated degradation. The new CRAd AdCB016-mp53(268N) was analyzed for its lytic replication properties in cervical carcinoma cell lines, HPV-immortalized keratinocyte cell lines representing dysplastic cells, and primary human keratinocytes. AdCB016-mp53(268N) exhibited 10- to 1000-fold greater efficacy than AdCB016 on high-risk HPV-positive cervical carcinoma cells and HPV-immortalized keratinocytes. Importantly, infection with AdCB016-mp53(268N) did not affect primary nonmalignant human keratinocytes. This favorable efficacy and safety profile was confirmed in organotypic raft cultures. Our findings suggest that AdCB016-mp53(268N) is a promising new agent for treatment of HPV-associated human cancers.
The effect of leukotrienes C4 and D4 on microcirculatory flow in humans
Authors: H. BISGAARD, J. KRISTENSEN, J. SONDERGAARD
Journal: British Journal of Dermatology (2006)

By quantifying the flare response, leukotrienes LTC4 and LTD4 were shown to increase the microcirculatory flow in a sigmoidal dose-response relation over the dose-range of 6.25-800 pmol. LTD4 was found to be more potent than LTC4 after 5 min, but not after 15 min, as estimated by this method. Laser-Doppler flowmeter studies confirmed that LTD4 is a more potent vasodilator than LTC4.
Sexual strategic pluralism through a Brunswikian lens
Authors: Aurelio José Figueredo, W. Jake Jacobs
Journal: Behavioral and Brain Sciences (2000)

Genes controlling the choice of sexual strategy must be sensitive to critical environmental contingencies, including the presence of other strategically relevant genetic traits. To determine which strategy works best for each individual, one must assess both its environment and itself within that environment. Psychosexual development involves an assessment of sociosexual affordances, strategically calibrating optimal utilization of physical and psychosocial assets.
Health care participants' dualism: are new sub-species evolving?
Authors: J. Braithwaite, J. I Westbrook, R. A Iedema
Journal: Journal of the Royal Society of Medicine (2007)

Humans are distinctive primates behaviourally, yet are also uncannily like chimpanzees. Both evolved for survival in places such as the forbidding African savannah and are thus good at sustaining themselves through activities such as resource foraging and socio-political navigating.1 Amongst humans, this can be observed in both hunter-gatherer and modern technological habitats. Life can be tough in each setting. To get more resources and succeed politically, many humans strive to move from being one of the troops to a place of power—the classic alpha male or socially predominant female.

This is especially noticeable amongst that most interesting of cultural groups, the health reformers, who by definition have climbed up the primate hierarchy to a position of authority. These are ministers for health, heads of health departments or private hospital chains, chief executives of trusts, directorate leaders, and others in senior policy and management ranks. They can be contrasted with the staff who occupy posts with little formal influence. We have come variously to call these ‘workers’, ‘clinicians’ and ‘the shop floor’.

It is eerily as if there are two emerging, recently evolved, sub-species. Homo commandus controlus and Homo extremus flexibilitus, while often co-inhabitants of the health environment and externally similar to each other, display contrasting cognitions and behaviours. Exposing and understanding these two sub-species, we argue, is important in determining whether and how the health system works. Early identification of the sub-species in situ will allow participants to understand events and reduce fall out damage to themselves. Personal and sub-group survival is, after all, the name of the game in heavily threatening environments.
The Generic H &amp;amp; P
Authors: Frederick L. Brancati
Journal: JAMA (1989)

8 AM—the end of another long call night and time for attending rounds. Your team awaits you. "Gee, you look terrible. How many did you get last night?" "Seven. Actually, eight if you count that ICU transfer. Not too bad." Not too bad for an intern like you, but a killer call night for a lesser house officer. You know it and they know it—you're Chief Resident material. You reach into your pocket for that stack of index cards, your notes from last night. Instead, you discover a Hemoccult card, some Kleenex, and a gum wrapper. No note cards. Your cheeks flush. Beads of sweat collect on your upper lip. You feel your esophagus twist like a rubber band in a model airplane. You spent most of last night learning the intricacies of your patients' lives and illnesses, but right now your mind's a blank. How can you honestly present
Enhancing production of ergosterol in Pichia pastoris GS115 by over-expression of 3-hydroxy-3-methylglutaryl CoA reductase from Glycyrrhiza uralensis
Authors: Ying Liu, Xiaoqing Zhu, Wendong Li, Hao Wen, Ya Gao, Yong Liu, Chunsheng Liu
Journal: Acta Pharmaceutica Sinica B (2014)

The rate-limiting enzyme in the mevalonic acid (MVA) pathway which can lead to triterpenoid saponin glycyrrhizic acid (GA) is 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). In order to reveal the effect of copy number variation in the HMGR gene on the MVA pathway, the HMGR gene from Glycyrrhiza uralensis Fisch. (GuHMGR) was cloned and over-expressed in Pichia pastoris GS115. Six recombinant P. pastoris strains containing different copy numbers of the GuHMGR gene were obtained and the content of ergosterol was analyzed by HPLC. The results showed that all the recombinant P. pastoris strains contained more ergosterol than the negative control and the strains with 8 and 44 copies contained significantly more ergosterol than the other strains. However, as the copy number increased, the content of ergosterol showed an increasing–decreasing–increasing pattern. This study provides a rationale for increasing the content of GA through over-expressing the GuHMGR gene in cultivars of G. uralensis.
Reduction of ischemic ST deviation and regional wall motion dysfunction during PTCA of the Left Anterior Descending Coronary Artery (LAD) with Synchronized Coronary Sinus Retroperfusion (SRP)
Authors: Alexander Popov, David M. Lasorda, Christopher A. Nienaber, C.R. Talbert, Kirk L. Parr, Mitchell W. Krucoff, Eliot Corday, Bryan C. Donohue
Journal: Journal of the American College of Cardiology (1996)
Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo
Authors: Gaelle Creusat, Jean-Sébastien Thomann, Anne Maglott, Bénédicte Pons, Monique Dontenwill, Eric Guérin, Benoit Frisch, Guy Zuber
Journal: Journal of Controlled Release (2011)
Neurally Mediated Negative Inotropic Effect Impairs Myocardial Function During Cholinergic Coronary Vasoconstriction in Pigs
Authors: Juan Cinca, Ana Carren˜o, Llui´s Mont, Pedro Blanch, J. Soler-Soler
Journal: Circulation (1996)

Background Myocardial dysfunction elicited during cholinergic coronary vasospasm is generally ascribed to myocardial ischemia. However, when pericoronary nerves extend to the ventricles, efferent vagal discharges that elicit coronary vasoconstriction may, at the same time, depress myocardial contractility by releasing acetylcholine into the myocardium. We analyzed whether a neurally mediated effect contributes to impairment of ventricular function during cholinergic coronary vasoconstriction. Methods and Results Left ventricular (LV) function, ECG mapping, and coronary angiography were analyzed during pericoronary application of methacholine (MCh) to the left anterior descending coronary artery in 53 chloralose-anesthetized open-chest pigs. MCh induced local coronary vasoconstriction and depressed coronary blood flow (13.3±3.7 to 6.0±4.6 mL/min [54%]; ANOVA, P &lt;.001), systolic LV pressure (105±10 to 91±10 mm Hg [13%], P &lt;.001), peak LV (+)dP/dt (2890±524 to 2270±447 mm Hg/s [21%], P &lt;.001), peak LV (−)dP/dt (1446±484 to 1048±276 mm Hg/s [27%], P &lt;.001), and regional systolic segment shortening (0.32±0.09% to 0.18±0.14% [43%], P =.02) and caused local ST-segment elevation (0.9±0.8 to 8.4±3.9 mV, P &lt;.001). These changes were not preceded by heart rate variations, were reproducible, and were inhibited by atropine. MCh during perfusion of nitroglycerin (2 μg·kg − 1 ·min − 1 IV) continued to depress LV pressure (9%, P =.002), LV (+)dP/dt (16%, P &lt;.01), LV (−)dP/dt (20%, P &lt;.01), and segment shortening (18%, P =.03) even though coronary blood flow drop was markedly attenuated (7% versus 54%; ANOVA, P &lt;.01). Disruption of pericoronary nerves with phenol attenuated MCh-induced LV pressure fall ( P &lt;.05). Histological data show that cholinergic and adrenergic pericoronary nerves extend into the ventricular myocardium. Conclusions A neurally mediated effect, in addition to ischemia, impairs LV function during cholinergic coronary constriction in a model with pericoronary nerves extending into the ventricles.
Tracheal Granuloma After Tracheal Intubation Incidentally Detected on Ga-67 Imaging
Authors: WAN-YU LIN, TE-HSIN CHAO, SHYH-JEN WANG
Journal: Clinical Nuclear Medicine (2002)

From the Departments of Nuclear Medicine* and Surgery, † Taichung Veterans General Hospital, Taichung, Taiwan Received for publication November 29, 2001. Accepted January 10, 2002. Correspondence: Wan-Yu Lin, Department of Nuclear Medicine, Taichung Veterans General Hospital, 160, Taichung Harbor Road, Section 3, Taichung 40705, Taiwan. E-mail: [email protected]
Effects of glucagon on adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in human plasma and urine
Authors: Arthur E. Broadus, Neil I. Kaminsky, Robert C. Northcutt, Joel G. Hardman, Earl W. Sutherland, Grant W. Liddle
Journal: Journal of Clinical Investigation (1970)

Glucagon, infused intravenously into fasting, well-hydrated, normal men in doses of 25-200 ng/kg per min, induced up to 30-fold increases in both plasma and urinary cyclic AMP. Cyclic GMP levels were unaffected by glucagon. Simultaneous cyclic AMP and inulin clearance studies demonstrated that the glucagon-induced increase in urinary cyclic AMP was entirely due to glomerular filtration of the elevated plasma levels of the nucleotide. The cyclic AMP response to glucagon was not mediated by parathyroid hormone or epinephrine, and trypsintreated glucagon was completely inactive. The perfused rat liver released cyclic AMP into the perfusate in response to glucagon, indicating that the liver is a possible source of the cyclic AMP entering the extracellular fluids in response to glucagon in vivo.
Influence of the thyroid state on left ventricular tension-velocity relations in the intact, sedated dog
Authors: Roger R. Taylor, James W. Covell, John Ross
Journal: Journal of Clinical Investigation (1969)

The mechanical properties of left ventricular contraction were described in terms of tension, velocity, length, and time in closed-chest, sedated normal, hypothyroid, and hyperthyroid dogs. Heart rate was controlled at 150 beats/min, and instantaneous contractile element velocity was calculated from left ventricular pressure and its first derivative during isovolumic left ventricular contractions, produced by sudden balloon occlusion of the ascending aorta during diastole. Wall tension was derived from ventricular pressure and volume, the latter being obtained from the pressure-volume relation of the arrested ventricle, and tension-velocity relations were analyzed over a range of ventricular endiastolic volumes. At any level of ventricular volume, the hypothyroid state was associated with a displacement of the tension-velocity relation of the left ventricle downwards and to the left, and the time to peak tension was prolonged (154 msec, normal 139 msec). In the hyperthyroid state, the tension-velocity relation of the left ventricle was displaced upwards and to the right, and the time to peak tension was reduced (80 msec). The changes in the tension-velocity relations indicate that the inotropic state of the left ventricle in the intact dog varies directly with the animal's thyroid state. This influence on myocardial contractility necessarily constitutes an important and integral part of the response of the intact circulation to altered thyroid state.
1193 ANTIGEN PROCESSING AND PROTEASOME DEGRADATION PATHWAYS ARE INVOLVED IN PATIENTS WITH CHRONIC HEPATITIS C WITH NEGATIVE PREDICTORS OF RESPONSE TO PEGYLATED INTERFERON AND RIBAVIRIN (PEG-IFN/RBV)
Authors: A. Birerdinc, A. Afendy, M. Stepanova, I. Younossi, G. Manyam, A. Baranova, Z. Younossi
Journal: Journal of Hepatology (2011)
Adrenal Dysfunction in Critically Ill Patients
Authors: Celso E. Gomez-Sanchez
Journal: New England Journal of Medicine (2013)

Critical illness elicits a major stress response that activates the hypothalamic–pituitary–adrenal (HPA) axis. Furthermore, the administration of corticotropin stimulates cortisol secretion and causes structural changes in the adrenal gland that include adrenal-cell hypertrophy and hyperplasia.1 Adrenal glands that are obtained on autopsy from patients who have died after a prolonged critical illness2 are relatively heavy, and progressively compact lipid-depleted cells replace lipid-laden fasciculata cells.2 The symptoms of patients with critical illness vary: many have hypotension and are receiving inotropes or vasopressors, whereas others have sepsis, and many have the systemic inflammatory response syndrome (SIRS).3 Subsequent adrenal failure in critically ill . . .
Sequential Involvement of Lck and SHP-1 with MHC-Recognizing Receptors on NK Cells Inhibits FcR-Initiated Tyrosine Kinase Activation
Authors: Bryce A. Binstadt, Kathryn M. Brumbaugh, Christopher J. Dick, Andrew M. Scharenberg, Brandi L. Williams, Marco Colonna, Lewis L. Lanier, Jean-Pierre Kinet, Robert T. Abraham, Paul J. Leibson
Journal: Immunity (1996)