Cimetidine and Granulocytopenia
Authors: JAMES W. FRESTON
Journal: Annals of Internal Medicine (1979)

Editorials1 February 1979Cimetidine and GranulocytopeniaJAMES W. FRESTON, M.D.JAMES W. FRESTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-264 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCimetidine already is used extensively in the United States and abroad. This histamine H2-receptor antagonist was approved by the Food and Drug Administration (FDA) in August 1977 for the treatment of duodenal ulcer disease, the Zollinger-Ellison syndrome, and other hypersecretory conditions. Despite the few approved indications, approximately 2 million patients in the United States had received the drug by October 1978. There are more approved indications in the United Kingdom, a circumstance that may help explain the remarkably heavy use in that country: Approximately 1% of the British population received the drug within 10 months of its release.It is axiomatic that...References1. CRAVENWHITTINGTON EJ: Agranulocytosis four months after cimetidine therapy (letter). Lancet 2:294-295, 1977 CrossrefMedlineGoogle Scholar2. JOHNSONBLACKHUGHESCLARKE NAAS: Leucopenia with cimetidine (letter). Lancet 2:1226, 1977 CrossrefGoogle Scholar3. KLOTZKAY SB: Cimetidine and agranulocytosis (letter). Ann Intern Med 88:579-580, 1978 LinkGoogle Scholar4. SELKERMOORELODOLCE RPD: Bone-marrow depression with cimetidine plus carmustine (letter). N Engl J Med 299:834, 1978 CrossrefMedlineGoogle Scholar5. UFBERGBROOKSBOSANACKINTZEL MCPJ: Transient neutropenia in a patient receiving cimetidine. Gastroenterology 73:635-638, 1977 CrossrefMedlineGoogle Scholar6. 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Ann Intern Med 90:257-261, 1979 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Gastroenterology University of Utah Medical Center Salt Lake City, Utah PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-induced immune dysregulation as a cause of atypical cutaneous lymphoid infiltrates: A hypothesisIs cimetidine associated with neutropenia?CHistamine-induced differentiation of HL-60 cellsChemical Agents Which Suppress Myelopoiesis: Agranulocytosis and LeukemiaCimetidine induced pancytopeniaAgranulocytosis after ranitidine administrationDrug therapy in peptic ulcer diseaseThe relationship between incorporation of histamine and differentiation of neutrophil progenitors in murine bone marrowNew horizons in the pharmacologic management of peptic ulcerationRanitidine and AgranulocytosisLINDA I. SHIELDS, M.D., JULIA A. 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IDrug-induced AgranulocytosisSevere Granulocytopenia with Cimetidine and PhenytoinELIZABETH SAZIE, M.D., JEFFRY P. JAFFE, M.D.Cimetidine-lnduced GranulocytopeniaHARRY W. CARLOSS, M.D., MEHDI TAVASSOLI, M.D., ROBERT MCMILLAN, M.D.Diet and ulcerative colitis.Cimetidine and thrombocytopenia.AntihistaminesCimetidine and Hematologic EffectsROBERT RATE, M.D., MARK BONNELL, M.D., CAROL CHERVENAK, R.PH., GARY PAVINICH, R.PH.Bone-Marrow Suppression Associated with CimetidineHENRY K. CHANG, M.D., STEPHEN L. MORRISON, M.D.Cimetidine in the Management of Peptic Ulcer DiseaseCimetidine, Lupus Erythematosus, and GranulocytopeniaGEOFFREY O. LITTLEJOHN, M.B., B.S., MURRAY B. UROWITZ, M.D.Cimetidine and Impaired Renal FunctionGORDON D. LUK, M.D., WENDY J. LUK, M.S., THOMAS R. HENDRIX, M.D.Cimetidine and AgranulocytosisFIRAS H. AL-KAWAS, M.D., BRUCE A. LENES, M.D., RONALD A. SACHER, M.D.Adverse Effects of Newly Marketed Drugs 1 February 1979Volume 90, Issue 2Page: 264-265KeywordsDrugsDuodenal ulcersFood and Drug AdministrationHistamineZollinger Ellison syndrome Issue Published: 1 February 1979 Copyright & Permissions©1979 American College of PhysiciansPDF downloadLoading ...