tbuckley/cabot-search huggingface dataset:
Persistence and Responsiveness of Immunologic Memory in the Absence of Secondary Lymphoid Organs
Authors: Juan E. Moyron-Quiroz, Javier Rangel-Moreno, Louise Hartson, Kim Kusser, Michael P. Tighe, Kimberly D. Klonowski, Leo Lefrançois, Linda S. Cauley, Allen G. Harmsen, Frances E. Lund, Troy D. Randall
Journal: Immunity (2006)
Approach to Management of the Heartbeating `Brain Dead' Organ Donor
Authors: Joseph M. Darby
Journal: JAMA (1989)

In recent years, transplantation has assumed an important role in the treatment of patients with end-stage diseases of most major organ systems. However, the greatest limitation in organ transplantation today is organ supply. Among factors that can affect the organ supply favorably, donor management has received the least attention. This review addresses management of the multi-organ donor within the intensive care unit. With an increased awareness of donor management issues and the application of a rational physiological approach, the supply of functional organs for transplantation can be increased. (<i>JAMA</i>. 1989;261:2222-2228)
Reviews, Notes, and Listings: Pulmonary Medicine: The Airway: Emergency Management
Authors: Daniel F. Danzl
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 February 1993Reviews, Notes, and Listings: Pulmonary Medicine: The Airway: Emergency ManagementDaniel F. Danzl, MDDaniel F. Danzl, MDUniversity of Louisville, Louisville, KY 40292.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00050 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Airway: Emergency ManagementRobert H. Dailey, Barry Simon, Gary P. Young, and Ronald D. Stewart; eds. 84 pages. St. Louis: Mosby-Year Book; 1992. $64.00.Resuscitative efforts have come a long way since World War I litter-bearers were cautioned that “he who looks at heaven … will soon be there”. However, we still transport and resuscitate patients in the supine position and thus at risk for aspiration. Parenthetically, the senior editor whimsically challenges the evolutionary advantage of our common orifice for respiration and alimentation. How else can you eat your own words?This book is a novel attempt to secure an insecure orifice ... Author, Article, and Disclosure InformationAffiliations: University of Louisville, Louisville, KY 40292. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 239KeywordsAlgorithmsAttentionLearning curvesNystagmusPharmacologyPulmonary medicineRespirationSpinal cord injuryTracheaVentilators Issue Published: 1 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The novel calicheamicin-conjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells
Authors: J F de Vries, C M Zwaan, M De Bie, J S A Voerman, M L den Boer, J J M van Dongen, V H J van der Velden
Journal: Leukemia (2011)
ABC of arterial and venous disease: Acute limb ischaemia
Authors: K. Callum
Journal: BMJ (2000)

Objectives To identify the type and extent of weapons being carried among young people in Scotland, and to determine the relation between use of illegal drugs and weapon carrying.Design Questionnaire school survey.Setting Independent schools in central Scotland and schools in Lanarkshire and Perth and Kinross.Participants 3121 students aged 11 to 16 in 20 schools.Main outcome measures Self completion questionnaire reporting history of drug use and weapon carrying.Results Overall, 34.1% of males and 8.6% of females reported having carried a weapon (P < 0.0001), ranging from 29.2% of boys aged 11-13 (classes S1 to S2) to 39.3% of boys aged 13-15 (S3 to S4).These values are higher than those in a recent survey of young people in England.Weapon carrying in Lanarkshire was 70% higher for males than in the rural area of Perth and Kinross.Both males and females who had taken drugs were more likely to carry weapons (63.5% of male drug users versus 20.5% of non-users and 22.8% of female drug users versus 3.7% of non-users; both P < 0.0001).The proportions of males carrying weapons who used none, one, two, three or four, or five or more illegal drugs were 21%, 52%, 68%, 74%, and 92% respectively.A similar trend was found among females.Conclusions Better information is needed on the nature and extent of weapon carrying by young people in the United Kingdom, and better educational campaigns are needed warning of the dangers of carrying weapons.
Validation of a basophil activation test (BAT) for the diagnosis of birch pollen associated apple-mediated oral allergy syndrome (OAS)
Authors: D.G. Ebo, C. Toelen, S. Van Tongelen, A.J. Schuerweigh, C.H. Bridts, L.S. De Clerck, W.J. Stevens
Journal: Journal of Allergy and Clinical Immunology (2003)
580 HIGH CHROMOSOME INSTABILITY AND OCCASIONAL R249S TP53 MUTATION CHARACTERIZE HEPATOCELLULAR CARCINOMA IN ROMANIA
Authors: A. Marchio, A.-M. Tanase, T. Dumitrascu, M. Mihaila, S. Dima, A. Dejean, I. Popescu, G. Oprisan, P. Pineau
Journal: Journal of Hepatology (2010)
Absorption of enteric-coated prednisolone.
Authors: H F West
Journal: BMJ (1979)

<h3>Background</h3> Seat belt use is an effective way to reduce the morbidity and mortality of motor vehicle crashes. However, 1 in 10 adults do not always wear a seat belt, with the lowest use rates of seat belt use among young adults. Digital behavioral interventions could be useful to increase seat belt use, but remain under-developed. This randomized clinical trial tested the efficacy of a 6-week behavioral text message program promoting seat belt use among young adults. <h3>Methods</h3> A parallel, 2-group, single-blind, individually randomized clinical trial. Eligible individuals recruited from 4 Emergency Departments were aged 18 to 25 years who reported driving or being a passenger without always using a seat belt in the past 2-weeks. Two hundred eighteen participants completed the 2-week trial run-in phase were randomly assigned 1:1 to intervention: self-monitoring control. The intervention arm (n = 110) received <i>SaVE</i>, a 6-week automated interactive text message program including weekly seat belt use queries with feedback and goal support to promote consistent use of a seat belt. The control arm (n = 108) received identical weekly seat belt use queries but no additional feedback. The primary and secondary outcomes were the proportion of young adults reporting always wearing a seat belt at 6- and 12-weeks, collected via web-based self-assessments and analyzed under intent-to-treat models. <h3>Results</h3> The mean (SD) age was 21.5 (2.2) years, 137 (63%) were female, 110 (50%) were White, and 33 (15%) were Hispanic. The 6-week follow-up rate was 86.2% (n = 187), with no differential attrition. At 6-weeks, 39.1% (95% CI, 30.0%-48.9%) of intervention participants always wore a seat belt vs. 23.1% (95% CI, 15.6%-32.2%) of control participants (odds ratio, 2.13; 95% CI, 1.18-3.84; <i>P</i> = .01). The 12-week follow-up rate was 64.2% (n = 140), with no differential attrition. At 12 weeks, 42.7% (95% CI, 15.6%-32.2%) of intervention participants always wore a seatbelt vs. 32.3% (95% CI, 20.6%-44.0%) of control participants (odds ratio, 1.25; 95% CI, 0.67-2.31; <i>P</i>=.48). <h3>Conclusions</h3> Results of this randomized clinical trial demonstrated that an interactive text message intervention using goal support was more effective at promoting seat belt use among targeted young adults than self-monitoring at 6-weeks. These findings, if replicated, suggest a scalable approach to help improve seat belt use and reduce crash-related morbidity and mortality. <h3>Trial registration</h3> ClinicalTrials.gov Identifier: NCT03833713
JL1, a novel differentiation antigen of human cortical thymocyte.
Authors: S H Park, Y M Bae, H J Kwon, T J Kim, J Kim, S J Lee, S K Lee
Journal: The Journal of Experimental Medicine (1993)

Expression of a novel thymocyte differentiation antigen, JL1, defined by a monoclonal antibody (mAb) developed against human thymocytes showed a specificity for stage II double positive (CD4+CD8+) human cortical thymocytes. This antigen was not expressed at detectable levels on medullary thymocytes, mature peripheral leukocytes, bone marrow cells or on other types of tissues elsewhere in the human body. Immunohistologic analysis revealed that JL1 had a clear pattern of distribution on cortical thymocytes. Immunoprecipitation of 125I-labeled cell lysates from human thymocytes and Molt-4 leukemic cell line with anti-JL1 mAb yielded a 120-130-kD single chain glycoprotein. When immunoprecipitation of cell lysate was done after endoglycosidase F treatment, JL1 antigen was still detected by antibody but the band showed a reduction in apparent molecular mass of approximately 5 kD. This suggests that, although JL1 molecule contains carbohydrate group, this does not form a critical part of the antigenic determinant for anti-JL1 antibody. JL1 antigen appears to be the first double positive, stage-specific differentiation antigen of human thymocyte reported so far. This antigen would be a useful marker for lymphoblastic malignancy of stage II thymocyte origin and it may be involved in the thymocyte education process.
A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
Authors: Sophie Chabot, Nabila Jabrane-Ferrat, Karine Bigot, Julie Tabiasco, Alexandra Provost, Muriel Golzio, Muhammad Zaeem Noman, Jérôme Giustiniani, Elisabeth Bellard, Stéphanie Brayer, Maryse Aguerre-Girr, Fabienne Meggetto, Sylvie Giuriato, François Malecaze, Stéphane Galiacy, Jean-Philippe Jaïs, Olivier Chose, Jean Kadouche, Salem Chouaib, Justin Teissié, Marc Abitbol, Armand Bensussan, Philippe Le Bouteiller
Journal: The Journal of Experimental Medicine (2011)

Angiogenesis plays an essential role in several diseases of the eye and in the growth of solid tumors, but existing antiangiogenic therapies have limited benefits in several cases. We report the antiangiogenic effects of a monoclonal antibody, CL1-R2, in several animal models of neovascularization. CL1-R2 recognizes human CD160, a membrane receptor which is conserved in various mammal species. We show that CD160 is expressed on the endothelial cells of newly formed blood vessels in human colon carcinoma and mouse B16 melanoma but not in vessels of healthy tissues. CL1-R2 reduced fibroblast growth factor 2–induced neovascularization in the rabbit cornea, in a mouse model of oxygen-induced retinopathy, and in a mouse Matrigel plug assay. Treatment of B16 melanoma-bearing mice with CL1-R2 combined with cyclophosphamide chemotherapy caused regression of the tumor vasculature and normalization of the remaining vessels as shown by Doppler ultrasonography, intravital microscopy, and histology. These studies validate CD160 as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.
Association Between Respiratory Tract Methicillin-Resistant S&lt;emph type="ital"&gt;taphylococcus aureus&lt;/emph&gt; and Survival in Cystic Fibrosis
Authors: Elliott C. Dasenbrook, William Checkley, Christian A. Merlo, Michael W. Konstan, Noah Lechtzin, Michael P. Boyle
Journal: JAMA (2010)

YSTIC FIBROSIS (CF) IS THE most common lethal autosomal recessive disorder in white individuals. 1Individuals with CF are living longer, and the median predicted survival age is now older than 37 years. 2The most common cause of death in CF is respiratory failure secondary to pulmonary infection.While Pseudomonas aeruginosa and Burkholderia cepacia complex are the pathogens most commonly associated with a shortened life span, there has been an increase in the prevalence of several potentially pathogenic microorganisms in CF.Methicillin-resistant Staphylococcus aureus (MRSA) is one such important emerging pathogen.The prevalence of respiratory tract MRSA in CF patients is now more than 20%. 2 Some MRSA strains contain virulence factors that may augment its ability to damage host tissue, 3 such as that seen in CF patients with invasive lung infections associated with Panton-Valentine leukocidin-positive MRSA. 4 The impact of MRSA on outcomes in CF remains unclear.We have previously shown in a large epidemiologic study that lung function decline is more rapid in CF children and adolescents with persistent MRSA compared with those without MRSA. 5However, this association was not seen in adults, and a recent smaller study concluded MRSA was not associated with more rapid lung function decline. 6The degree of interest in MRSA among CF caregivers is
Blood and vein-wall fibrinolytic activity in health and vascular disease.
Authors: N L Browse, L Gray, P E Jarrett, M Morland
Journal: BMJ (1977)

The resting blood fibrinolytic activity of 120 normal subjects and 294 patients with various forms of vascular disease was assessed by measuring the dilute blood clot lysis time and fibrin plate lysis area before and after 10 minutes of venous congestion. The tissue fibrinolytic activity of several of these subjects was assessed in vein biopsy specimens. The results suggested that there was a correlation between blood and tissue fibrinolytic activity and that certain venous diseases, particularly recurrent superficial thrombophlebitis and venous liposclerosis, were associated with a deficiency of blood and tissue fibrinolytic activity.
Tumoral Calcinosis--an Unrecognized Disease
Authors: S. McClatchie, A. D. Bremner
Journal: BMJ (1969)

Twenty-six cases of tumoral calcinosis are reported from Kenya. The disease, frequently misdiagnosed, is of unknown origin. It presents as calcified tumours, usually around the hips and buttocks, in muscle and subcutaneous tissue. The tumours are partly solid, partly multiloculated cysts which contain a chalky fluid. They may grow rapidly or very slowly, and are found in children and adults. Both sexes are affected and there is no obvious tribal or geographical localization.
INEBRIETY AND TUBERCULOSIS, ALLIED DISEASES.
Authors: T. D. CROTHERS
Journal: JAMA (1898)

permanently derange the dynamic equilibrium of the nerve centers.Its repetition fixes this condition, and the power of resistance to disease becomes less.Local inflammation from infectious agents, from injuries, strains and drains, can not be overcome and death fol- lows.Alcohol has been the factor which made these conditions possible, and destroyed the vis medica naturce.In this general outline of the facts concerning the power of alcohol as a factor in central nerve disease, the following facts may be restated:1. Alcohol is a poison of the narcotic class, with a special tendency to act on the brain and nervous system.
Immunisation of children born to mothers positive for anti-HBe.
Authors: K. R. Neal, J. M. Radford
Journal: BMJ (1992)

transmission should therefore be explored.As cases in infants now seem to be making a consider- able contribution to endemic transmission (table ), one approach would be to offer infants early measles vaccination before giving measles, mumps, and rubella vaccine in the second year of life.Studies to determine the serological response to early vaccination in infants of vaccinated and naturally immune mothers and the accuracy of a clinical diagnosis of measles in infants and older age groups are under way, together with theoretical studies to explore the impact of such a strategy.An epidemiologically and logistically different approach to routinely offering two doses would be to attempt to vaccinate all subjects in a wide age range within a short time and thereby interrupt transmission.This has recently been done in the English speaking Caribbean, where over 95% of all children aged 1-15 in eight of the 17 islands were vaccinated within one month.'To ensure elimination this initiative must be repeated periodically, the interval and targeted age groups being decided on the basis of epidemiological data such as the age specific prevalence of the antibody,6 and results of theoretical studies.Clearly, further work is required to provide a sound scientific basis for deciding future policy.We suggest that in the short term the cost effectiveness of offering measles, mumps, and rubella vaccine to secondary school children should be decided locally on the basis of a district's previous uptake of measles vaccine and present age specific notification rates.
Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process
Authors: Masayuki Ishihara, Kuniaki Nakanishi, Katsuaki Ono, Masato Sato, Makoto Kikuchi, Yoshio Saito, Hirofumi Yura, Takemi Matsui, Hidemi Hattori, Maki Uenoyama, Akira Kurita
Journal: Biomaterials (2002)
Acute haemodynamic effect of taurine on hearts in vivo with normal and depressed myocardial function
Authors: N. AWATA, J. AZUMA, T. HAMAGUCHI, Y. TANAKA, H. OHTA, K. TAKIHARA, H. HARADA, A. SAWAMURA, S. KISHIMOTO
Journal: Cardiovascular Research (1987)

The acute haemodynamic effects of taurine were studied in normal and in beta blocker (propranolol) or calcium antagonist (diltiazem) treated rabbits and in rabbits with experimentally produced chronic aortic regurgitation. The administration of taurine (25 mg.kg-1) did not affect heart rate and left ventricular end diastolic pressure but produced significant increases in left ventricular dP/dtmax, cardiac output, and left ventricular systolic pressure in control hearts, indicating that intravascularly administered taurine substantially increased cardiac performance. In propranolol (1 mg.kg-1) treated rabbits taurine significantly improved left ventricular dP/dtmax and cardiac output, which were previously depressed by propranolol. Taurine had the same effect on diltiazem (1 mg.kg-1) treated rabbits. In rabbits with aortic regurgitation a bolus injection of taurine improved cardiac performance. Continuous infusion of taurine (100 mg.h-1) also produced a significant increase in left ventricular dP/dtmax. These results suggest that taurine has a unique action as an inotropic agent and that it may be useful in the treatment of patients with congestive heart failure.
Prinzmetal Angina and Cyproheptadine
Authors: Julian L. Ambrus
Journal: Annals of Internal Medicine (1995)

Letters15 January 1995Prinzmetal Angina and CyproheptadineJulian L. AmbrusJulian L. AmbrusBuffalo General Hospital, Buffalo, NY 14203. Mount Sinai MedicalSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-2-199501150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Schecter and colleagues [1] reported that a subset of patients with Prinzmetal angina who were refractory to nitrites and calcium channel blockers responded to the antiserotonergic agent cyproheptadine. Little information is available on the mechanisms of action involved or on why some other antiserotonergic agents were inactive in this disorder.In an earlier study [2], we found that cyproheptadine substantially inhibited platelet aggregation in vivo, ex vivo, and in vitro. It inhibited both serotonin and adenosine diphosphate-induced aggregation. The agent also has antihistamine activity. Inhibition of platelet aggregation may break the vicious cycle in which serotonin is ...References1. Schecter AD, Chesebro JH, Fuster V. Refractory Prinzmetal angina treated with cyproheptadine. Ann Intern Med. 1994; 121:113-4. Google Scholar2. Ambrus JL, Ambrus CM, Thurber LE. Study of platelet aggregation in vivo. V. Effect of the antiserotonin agent cyproheptadine. J Med. 1977; 8:287-94. Google Scholar Author, Article, and Disclosure InformationAuthors: Julian L. AmbrusAffiliations: Buffalo General Hospital, Buffalo, NY 14203. Mount Sinai Medical PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1995Volume 122, Issue 2Page: 155KeywordsAdenosineAnginaAntihistaminesAttentionCalcium channel blockerPlatelet aggregationPlateletsSerotonin ePublished: 15 August 2000 Issue Published: 15 January 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CDKN2A mutations in Scottish families with cutaneous melanoma: results from 32 newly identified families
Authors: J. Lang, M. Boxer, R.M. MacKie
Journal: British Journal of Dermatology (2005)

Journal Article CDKN2A mutations in Scottish families with cutaneous melanoma: results from 32 newly identified families Get access J. Lang, J. Lang Duncan Guthrie Institute of Medical Genetics, Royal Hospital for Sick Children and University of Glasgow, Glasgow, U.K Search for other works by this author on: Oxford Academic Google Scholar M. Boxer, M. Boxer Duncan Guthrie Institute of Medical Genetics, Royal Hospital for Sick Children and University of Glasgow, Glasgow, U.K Search for other works by this author on: Oxford Academic Google Scholar R.M. MacKie R.M. MacKie Duncan Guthrie Institute of Medical Genetics, Royal Hospital for Sick Children and University of Glasgow, Glasgow, U.KDepartment of Public Health, University of Glasgow, Glasgow G12 8RZ, U.K Rona M. MacKie. E‐mail: r.m.mackie@clinmed.gla.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 6, 1 December 2005, Pages 1121–1125, https://doi.org/10.1111/j.1365-2133.2005.06846.x Published: 01 December 2005 Article history Accepted: 15 April 2005 Published: 01 December 2005
Pneumocephalus Associated with Pneumosinus Dilatans Frontalis
Authors: Neil Bhattacharyya, Robert M Friedlander
Journal: New England Journal of Medicine (2007)

An 87-year-old woman presented to the emergency department with an acute-onset severe global headache of 36 hours' duration, with greater occipital involvement than frontal involvement. She reported no recent trauma, prior sinus surgery or sinusitis, fevers, chills, neck stiffness, or photophobia, and she had no clinically relevant medical history. Physical examination showed that she was afebrile, alert, and oriented, with a supple neck. Her neurologic examination, including funduscopy and a leukocyte count, was normal. Computed tomography of the head and paranasal sinuses revealed pneumocephalus involving the anterior and middle cranial fossae (Panel A), without evidence of herniation. In addition, there . . .
Sir Robert Jones Memorial
Authors: None Derby, A. Stanley, H. J. Waring, None Moynihan, E. F. Buzzard, W. L. Brown, J. W. Dowden, F. Crawley, H. B. Fawcus, None Wicklow, W. Portland, A. F. London, A. Liverpool, H. R. Hurter, A. Gates, H. J. W. Hetherington, H. Stiles, R. E. Kelly, C. J. Macalister, W. I. d. C. Wheeler, C. T. Holland, D. P. D. Wilkie, G. Buller, A. G. Hunt, W. J. Mayo, C. H. Mayo, W. E. Gallie, A. Steindler, W. C. Campbell, D. F. P. Willard, V. Putti, G. Nove-Josserand, M. Jansen, H. A. T. Fairbank, R. C. Elmslie, W. R. Bristow, G. R. Girdlestone, H. Platt, N. Dunn, D. M. Artken, S. T. Irwin, T. P. McMurray, A. S. B. Bankart
Journal: BMJ (1933)
From an Excess of Fat, Diabetics Die
Authors: George Steiner
Journal: JAMA (1989)

In 1927, Joslin<sup>1</sup>prophetically wrote: "I believe the chief cause of premature development of arteriosclerosis in diabetes, save for advancing age, is an excess of fat, an excess of fat in the body (obesity), an excess of fat in the diet, and an excess of fat in the blood. With an excess of fat diabetes begins and from an excess of fat diabetics die, formerly of coma, recently of arteriosclerosis." Despite the seven decades that have passed and the considerable knowledge that has been gained since that time, physicians continue to pay little attention to the control of plasma lipid disorders in their diabetic patients. This is the conclusion reached by Stern and colleagues<sup>2</sup>in this issue ofThe Journal. It is well recognized that coronary artery disease is approximately 2.5 times more common in diabetics than in nondiabetics. The comparable figure for peripheral vascular disease is an