tbuckley/cabot-search huggingface dataset:
Is quantification of myocardial blood flow necessary to delineate resting perfusion abnormalities in patients with prior myocardial infarction?
Authors: Marcel Peltier, Agnés Pasquet, David Vancraeynest, Anne-Marie d'Hondt, Taniyel Ay, Jacques Melin, Jean-Louis Vanoverschelde
Journal: Journal of the American College of Cardiology (2002)
665. Novel Gammaretroviral Vectors for Gene Therapy of SCID-X1
Authors: Susannah I. Bailey, Steven J. Howe, Axel Schambach, Christine Kinnon, Christopher Baum, Adrian J. Thrasher
Journal: Molecular Therapy (2006)

SCID-X1 is caused by mutations in the gene encoding the common cytokine receptor gamma chain (IL2Rγc), resulting in profound defects in both cellular and humoral immunity. Sustained correction of 16 SCID-X1 patients have been reported by this method in 2 clinical trials in which expression of the IL2Rγc transgene is regulated by the gammaretroviral LTR. However, recent reports of three severe adverse events have reinforced the need to pursue vector development. One such alternative is that of the self-inactivating (SIN) LTR, whereby the transgene is regulated by a single internal promoter. This study aims to evaluate a novel series of gammaretroviral and lentiviral vectors for the treatment of SCID-X1. The γ-chain deficient mouse provides a convenient model with which to test gene therapy strategies. Lineage negative (lin –ve) bone marrow stem cells derived from γ-chain deficient mice were transduced ex vivo with a novel series of SIN gammaretroviral vectors and an existing LTR-based vector used for clinical study. Transduced cells were engrafted in lethally or sub-lethally irradiated RAG2/γc- deficient recipient mice. Data from preliminary in vivo experiments indicate that restoration of immune function can be achieved at similar levels with both the current LTR-driven vector and the novel SIN gammaretroviral vectors. Recovery of thymic development was associated with production of T cells capable of proliferation in response to mitogenic stimuli. Circulating lymphoid cells were detected in the blood at 3 months post-transplant and both T cells and mature B cells were present in spleen and bone marrow. Similar levels of immune reconstitution were also observed between vectors containing viral (spleen focus forming virus) and endogenous (elongation factor 1α) promoter sequences. Secondary transplants have also been performed and preliminary results indicate similar levels of immune reconstitution in these animals. These data suggest that the SIN vectors may provide an effective alternative to existing vectors currently used for gene therapy of this disorder.
GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia
Authors: X Meng, K Matlawska-Wasowska, F Girodon, T Mazel, C L Willman, S Atlas, I-M Chen, R C Harvey, S P Hunger, S A Ness, S S Winter, B S Wilson
Journal: Leukemia (2011)

Gamma secretase inhibitors (GSIs) comprise a growing class of compounds that interfere with the membrane-bound Notch signaling protein and its downstream intra-nuclear transcriptional targets. As GSI-I (Z-LLNle-CHO) is also a derivative of a widely used proteosome inhibitor MG-132, we hypothesized that this compound might be active in precursor-B acute lymphoblastic leukemia (ALL) cell lines and patient samples. We found that GSI-I treatment of precursor-B ALL blasts induced apoptotic cell death within 18–24 h. With confirmation using RNA and protein analyses, GSI-I blocked nuclear accumulation of cleaved Notch1 and Notch2, and inhibited Notch targets Hey2 and Myc. Microarray analyses of 207 children with high-risk precursor-B ALL demonstrate that Notch pathway expression is a common feature of these neoplasms. However, microarray studies also implicated additional transcriptional targets in GSI-I-dependent cell death, including genes in the unfolded protein response, nuclear factor-κB and p53 pathways. Z-LLNle-CHO blocks both γ-secretase and proteosome activity, inducing more robust cell death in precursor-B ALL cells than either proteosome-selective or γ-secretase-selective inhibitors alone. Using Z-LLNle-CHO in a nonobese diabetes/severe combined immunodeficiency (NOD/SCID) precursor-B ALL xenograft model, we found that GSI-I alone delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group, suggesting that this compound is worthy of additional testing.
American Pharmaceutical Association Practical Guide to Natural Medicines
Authors: Marc S. Micozzi
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes19 September 2000American Pharmaceutical Association Practical Guide to Natural MedicinesMarc S. Micozzi, MD, PhDMarc S. Micozzi, MD, PhDCollege of Physicians of Philadelphia, Philadelphia, Pennsylvania. (Micozzi)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-6-200009190-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Peirce A. 608 pages. New York: William Morrow; 1999. $35.00. ISBN 0688161510. Order phone 800-237-0657.Field of medicine: Complementary and alternative medicine.Format: Hardcover book.Audience: Health professionals and consumers.Purpose: To present credible information on a large selection of herbal remedies and materia medica in a ready-reference format.Content: After a short introduction on herbal remedies, entries on specific herbal remedies are presented in alphabetical order.Highlights: The entries are well referenced, and the index is cross-referenced by symptom and remedy.Limitations: The table of contents is sparse. The presentation is formulaic, and little information is provided on the ... Author, Article, and Disclosure InformationAffiliations: College of Physicians of Philadelphia, Philadelphia, Pennsylvania. (Micozzi) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBioactives in Disease Prevention and Health Promotion: Exploiting Combinatorial Effects 19 September 2000Volume 133, Issue 6Page: 487KeywordsComplementary and alternative medicineDrugsHerbal medicineSoftware toolsTraditional medicine ePublished: 19 September 2000 Issue Published: 19 September 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Child B: a personal view:
Authors: J A Dowey
Journal: BMJ (1997)

The death of Jaymee Bowen has once again raised ugly questions of when to treat children with a supposedly terminal medical condition. It is likely that, now that she has died, some people will consider the decision of the administrator who refused funding justified. This raises in me feelings of both fear and outrage because 33 years ago I was in Jaymee's position.

At the age of 7 I was diagnosed as having a brain lesion. I was in horrific pain and became more and more paralysed until I was unable to move my limbs. My parents were told that without an operation I would certainly die and with …
868. Novel Strategies To Inhibit Ocular Neovascularization Based on Sonic Hedgehog Pathway Blockade
Authors: Gabriella Cotugno, Enrico M Suace, Alberto Auricchio
Journal: Molecular Therapy (2006)

Ocular neovascularization is the major landmark of several common retinal and choroidal blinding diseases including proliferative diabetic retinopathy and age-related macular degeneration, for which no effective therapy is currently available. Recently we have observed that the Sonic Hedgehog (Shh) pathway is activated in animal models of retinal and choroidal neovascularization and that its pharmacological inhibition results in significant reduction of neovascularization in both models, suggesting this pathway as a new molecular target for treatment of ocular neovascular diseases.
Pemphigoid: Clinical, Histologic, Immunopathologic, and Therapeutic Considerations
Authors: Kim B. Yancey
Journal: JAMA (2000)

Autoimmune blistering diseases are generally distinct entities characterized by relatively consistent clinical, histologic, and immunopathologic findings. These disorders may cause impaired adhesion of epidermis to epidermal basement membrane (eg, the pemphigoid group of disorders [bullous, gestational, and mucous membrane]) or impaired adhesion of epidermal cells to each other (eg, the pemphigus group of disorders). Recent studies have shown that these disorders are characterized by autoantibodies that often display pathogenic (ie, blister-forming) activity in passive transfer models. Interestingly, the autoantigens targeted by these patients' autoantibodies represent important structural proteins that promote cell matrix (eg, pemphigoid) or cell-to-cell (eg, pemphigus) adhesion in skin. Autoimmune blistering diseases are characterized by substantial morbidity (pruritus, pain, disfigurement), and in some instances, mortality (secondary to loss of epidermal barrier function). Treatment with systemic immunosuppressives has reduced morbidity and mortality in patients with these diseases. JAMA. 2000;284:350-356
Local Skin-Fold Thickness as a Clinical Predictor of Depot Size During Basal Rate Infusion of Insulin
Authors: Per R Hildebrandt, Allan A Vaag
Journal: Diabetes Care (1993)

To determine the influence of local adiposity on insulin depot size during CSII at basal rate.In 27 diabetic patients, a constant infusion of 125I-labeled Actrapid insulin was given, with U-40 insulin at a rate of 1.12 IU/h in 20 patients, and U-100 at a rate of 1 IU/h in 7 patients. After 16 h of infusion, the steady-state depot size was measured by external counting, and the local skin fold was measured with a Harpenden skin-fold caliper.U-40 insulin infusion resulted in a steady-state depot size of 5.1 U (2.1-10.9 U), and a corresponding skin-fold thickness of 17.8 mm (5-34 mm). A positive correlation was found between depot size and skin-fold thickness. A similar correlation was observed with U-100 insulin.During basal rate CSII, large variations in local skin-fold thickness create large variations in the steady-state depot size, which is partly predictable just by lifting the skin fold.
Reduced EP2 Receptor Expression Accounts For Prostaglandin E2 Resistance In Nasal Polyp Fibroblasts From Patients With Aspirin Exacerbated Respiratory Disease; Possible Role For Histone Acetylation In Control Of EP2 Receptor Expression
Authors: Katherine N. Cahill, Derek Thibault, Benjamin A. Raby, Andrea Baccarelli, Neil Bhattacharyya, Joshua A. Boyce, Tanya M. Laidlaw
Journal: Journal of Allergy and Clinical Immunology (2014)
Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients
Authors: Jerome Tamburini, Caroline Elie, Valérie Bardet, Nicolas Chapuis, Sophie Park, Philippe Broët, Pascale Cornillet-Lefebvre, Bruno Lioure, Valérie Ugo, Odile Blanchet, Norbert Ifrah, Francis Witz, François Dreyfus, Patrick Mayeux, Catherine Lacombe, Didier Bouscary
Journal: Blood (2007)
In Defiance of Death: Exposing the Real Costs of End-of-Life Care
Authors: Michael Bevins
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dose-response relationship of fibrous dusts in intraperitoneal studies.
Authors: M Roller, F Pott, K Kamino, G H Althoff, B Bellmann
Journal: Environmental Health Perspectives (1997)

The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies with several fibrous dusts. Based on observed tumor incidences ranging between 10 and 90%, the hypothesis of a common slope of dose-response relationships (parallel probit lines in probit analysis) cannot be rejected. In general, parallelism of probit lines is considered an indication of a common mode of action. Analysis of the shape of the dose-response relationship, with one apparent exception, shows virtually linear or superlinear behavior, i.e., from these data, there is no indication of a decrease in carcinogenic potency of an elementary carcinogenic unit at lower doses.
Abstract A01: Evaluation of H3K27me3 and EZH2 in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant GBM
Authors: Sriram Venneti, Mihir Garimella, Lisa Sullivan, Daniel Martinez, Jason Huse, Adriana Heguy, Mariarita Santi, Craig Thompson, Craig Thompson, Judkins Alexander
Journal: Cancer Research (2013)

Abstract Histone H3F3A mutations are seen in ~30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V). Sixteen genes encode histone H3, each variant differing in only a few amino acids. Therefore how mutations in a single H3 gene contribute to carcinogenesis is unknown. H3F3A K27M mutations are predicted to alter methylation of H3K27. H3K27me3 is a repressive mark critical to stem cell maintenance and is mediated by EZH2, a member of the polycomb-group (PcG) family. We evaluated H3K27me3 and EZH2 expression using immunohistochemistry in 76 pediatric brain tumors. H3K27me3 was lowered/absent in tumor cells but preserved in endothelial cells and infiltrating lymphocytes in 6/20 GBMs. H3K27me3 showed strong immunoreactivity in all other tumor subtypes. Sequencing of GBMs showed H3F3A K27M mutations in all 6 cases with lowered/absent H3K27me3. Further, these 6 GBMs with lowered/absent H3K27me3 in tumor cells showed a worse prognosis than GBMs with preserved H3K27me3. EZH2 expression was high in GBMs, but absent/focal in other tumors. However, no significant differences in EZH2 expression were observed between H3F3A K27M mutant and wild type GBMs, suggesting that EZH2 mediated trimethylation of H3K27 is inhibited in GBM harboring K27M mutations. Our results indicate that H3F3A K27M mutant GBMs show decreased H3K27me3 that may be of diagnostic, prognostic and biological relevance. Citation Format: Sriram Venneti, Mihir Garimella, Lisa Sullivan, Daniel Martinez, Jason Huse, Adriana Heguy, Mariarita Santi, Craig Thompson, Craig Thompson, Judkins Alexander. Evaluation of H3K27me3 and EZH2 in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant GBM. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr A01.
DELETION OF b5 IMMUNOGLOBULIN-BEARING LYMPHOCYTES IN ALLOTYPE-SUPPRESSED RABBITS
Authors: Michael R. Harrison, Rose G. Mage, Joseph M. Davie
Journal: The Journal of Experimental Medicine (1973)

The proportion of peripheral blood lymphocytes with cell surface b5 immunoglobulin (Ig) was compared with serum b5 Ig levels in allotype-suppressed and recovering b5 homozygous rabbits in order to establish the cellular defect in suppression and to determine the relation between lymphocyte membrane Ig and secreted Ig of the same allotype. In rabbits fully suppressed for b5, the absence of circulating b5 Ig is reflected in a complete deletion of b5-bearing lymphocytes. During spontaneous escape from suppression, the appearance of b5-bearing lymphocytes precedes the appearance of detectable serum b5. During recovery from suppression b5-bearing lymphocytes recover rapidly toward normal levels, but circulating b5 levels remain chronically and disproportionately depressed.
Home-style nursing
Authors: M. K. House
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nebulisers for patients with HIV infection and AIDS
Authors: R. F. Miller, M. J. O'Doherty
Journal: Thorax (1997)

used and there are the most data about it. 5isodes Kent and CanterburyGiving the same or higher doses at increased (2) Treatment of Pneumocystis carinii pneumonia Hospital, (3) Sputum induction for diagnosis of respiratory frequency using this system confers no ad-Canterbury, Kent, UK episodes M J O'Doherty ditional protection.Its disadvantage is that it (4) Bronchodilation with 2 agonists, etc. (5)Ventilation scanning (with aerosols) in nuclear is a single use system and cannot be rinsed out
Success of climate change control depends on access to reproductive health care
Authors: J. Carlowe
Journal: BMJ (2009)

How well society looks after women could influence the future course of climate change, say key players from a major international development agency.

The State of World Population 2009 , a report by the United Nations Population Fund launched this week, notes that the world’s approach to issues such as family planning, reproductive health care, and relations between the sexes could affect how humanity adapts to rising seas, worsening storms, and severe droughts.⇓



The agency argues that international agreements and national policies on climate change are more likely to succeed if they take into account population dynamics, the relations between the sexes, and women’s wellbeing and access to healthcare services. …
Age, Sex, and Ethnic Variations in Serum Insulin Concentrations Among U.S. Youth
Authors: Earl S. Ford, Chaoyang Li, Giuseppina Imperatore, Stephen Cook
Journal: Diabetes Care (2006)

Distributions of serum concentrations of insulin among adolescents and young adults are poorly understood in the U.S. The objective of this study was to describe the distribution of serum insulin across demographic characteristics of U.S. adolescents and young adults.A total of 1,791 male and female subjects aged 12-19 years who participated in the National Health and Nutrition Examination Surveys for 1999-2002 were included in the analyses.Among male participants, serum concentrations of insulin increased from age 12 to 14 years before decreasing. Among female participants, concentrations were highest at age 13 years before decreasing steadily through age 19 years. Among participants aged 12-17 years but not those aged 18-19 years, females had higher mean log-transformed concentrations than males (P, Wald, F = 0.038 and 0.125, respectively) after adjusting for age and ethnicity. After adjusting for age and BMI percentile, mean log-transformed concentrations were higher in African-American females aged 12-17 years than in white or Mexican-American participants. No significant ethnic differences were found among female participants aged 18-19 years or male participants aged 12-19 years. Concentrations of insulin increased strongly with increasing levels of BMI.These results provide detailed information about serum concentrations of insulin in a representative sample of U.S. adolescents and young adults and may be useful to monitor future trends of this risk factor for diabetes and cardiovascular disease.
PERIPHERAL ENDOTHELIAL DYSFUNCTION IN HEART FAILURE WITH PRESERVED EJECTION FRACTION: A LINK WITH THE DEVELOPMENT OF PULMONARY HYPERTENSION
Authors: Evelyn Santiago Vacas, Marta Farrero Torres, Isabel Blanco, Montserrat Cardona, M Ángeles Castel, Marta Sitges, Barbara Vidal, Joan Albert Barberà, Felix Perez-Villa
Journal: Journal of the American College of Cardiology (2013)
Problems in reporting psychiatric disorders among homeless adults
Authors: M. A. Winkleby
Journal: JAMA (1990)

To the Editor.—  In the September 8, 1989, issue of JAMA , Breakey et al 1 present data on psychiatric disorders among a sample of 125 homeless men and 78 women from Baltimore, Md, missions, shelters, and jails. While this cross-sectional study uses standardized clinical diagnostic tools and addresses the important issue of comorbidity, it has been misinterpreted by the media and public policy advocates owing to several analytic shortcomings.  First, using the Diagnostic and Statistical Manual of Mental Disorders, Third Edition to estimate overall prevalence of psychiatric disorders, the authors report that 91% of men and 80% of women received an Axis I diagnosis—a statistic that was translated into major news by the Sunday New York Times (September 10, 1989) and the Associated Press. These statistics may be accurate estimates of the overall burden of disability associated with homelessness, yet they are of limited value because they aggregate the
A Red Flag
Authors: Reza Fazel, Gurpreet Dhaliwal, Sanjay Saint, Brahmajee K. Nallamothu
Journal: New England Journal of Medicine (2009)

A 64-year-old man was brought to the emergency department because of sudden-onset blurred vision in both eyes and diplopia, as well as a frontal headache that had begun earlier that day. On presentation, he was noted to have an altered mental status. There was no history of fevers, chills, or focal weakness.
Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide
Authors: Y Sun, S H Kim, D-C Zhou, W Ding, E Paietta, F Guidez, A Zelent, K H Ramesh, L Cannizzaro, R P Warrell, R E Gallagher
Journal: Leukemia (2004)