tbuckley/cabot-search huggingface dataset:
"Dim Regard for Clinical Allergy"
Authors: PHILIP S. NORMAN
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 May 1972"Dim Regard for Clinical Allergy"PHILIP S. NORMAN, M.D., LAWRENCE M. LICHTENSTEIN, M.D.PHILIP S. NORMAN, M.D.Search for more papers by this author, LAWRENCE M. LICHTENSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-828_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The comments that follow concern the paper "A Single Year of Immunotherapy for Ragweed Hay Fever," by Lichtenstein and colleagues, which appeared in the November issue (Ann Intern Med75:663-671). We have avoided publication regarding the effectiveness of desensitization (immunotherapy), which we nevertheless use as a routine and highly effective therapeutic procedure. We must suffer in silence because there is as yet no valid objective method with which to assess our results. The authors are commended for their efforts to fill the void, because we are all eagerly awaiting the discovery of a reliable method of quantitation.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Johns Hopkins University School of Medicine Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 828-829KeywordsAllergy and immunologyFevers ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Slow potentials in the atrioventricular junctional area of patients operated on for atrioventricular node tachycardias and in isolated porcine hearts
Authors: Jacques M.T. de Barker, Ruben Coronel, Mark A. McGuire, Jessica T. Vermeulen, Tobias Opthof, Sara Tasseron, Norbert M. van Hemel, Jo J.A.M. Defauw
Journal: Journal of the American College of Cardiology (1994)
Bundle Branch and Ventricular Activation in Man
Authors: KENNETH M. ROSEN, SHAHBUDIN H. RAHIMTOOLA, M. ZIAD SINNO, ROLF M. GUNNAR
Journal: Circulation (1971)

His (H), right bundle branch (RB), and left bundle branch (LB) potentials were recorded by electrode catheters passed into the left and right ventricles in seven patients without conduction defects. In another three patients, H and LB were recorded. Initial ventricular activation was considered to coincide with the onset of the QRS (Q). The following intervals were measured in milliseconds: H-Q, LB-Q, RB-Q, H-LB, H-RB, and LB-RB. The average and range of these was as follows: H-Q 46 (39-54), LB-Q 27 (24-30), RB-Q 25 (20-27), H-LB 20 (14-28), H-RB 21 (15-29), and LB-RB 2 (1-10). LB-RB was 3 msec or less in six of seven patients. Coupled atrial pacing produced delays in H-RB without effect on H-LB and LB-Q. The production of incomplete and complete right bundle branch block was related to increase in the LB-RB interval. One patient developed left bundle branch block (LBBB) during coupled pacing with delay of LB while RB-Q remained unchanged. H-Q intervals were measured in three additional patients with rate related LBBB during both control and block. Prolongation of H-Q was less than 3 msec during LBBB. It is concluded that the proximal left and right bundle branches are usually activated simultaneously in man, and that block of either bundle without contralateral bundle delay does not significantly delay the onset of ventricular activation.
Real-time quantitative PCR for detection of minimal residual disease before allogeneic stem cell transplantation predicts outcome in children with acute lymphoblastic leukemia
Authors: V.H. van der Velden, S.A. Joosten, M.P. Willemse, E.R. van Wering, A.W. Lankester, J.J.M. van Dongen, P.M. Hoogerbrugge
Journal: Leukemia (2001)
Finding a solution to hospital associated infections
Authors: Henry Creagh
Journal: BMJ (2008)

Google, the search engine giant, has launched Google Health, a free service for patients offering a personal electronic medical record (www.google.com/health).But the move has prompted fears over the security of health information stored in this way.President George Bush has promoted electronic health records as a means of reducing medical errors and cutting the costs of health care in the United States.But uptake has so far been slow.The new Google service will compete with similar services offered by other commercial internet health services, such as WebMD.Electronic medical histories are also stored by major health insurance companies.An individual will be able to create an account, protected by a password, and enter personal medical records, either by keying them in or by importing electronic records from hospitals, laboratories, and pharmacies that are Google Health partners.When new information is added the service will check for potential interactions between drugs, allergies, and conditions.Patients can also search for doctors by specialty or location and for hospitals, and they can permit their doctors or others to see their medical information and add to it.The New York Times reported that the service was popular when tested among patients at the Cleveland Clinic in Ohio earlier this year (www.nytimes.com,20 May, "Google offers personal health records on the web").The system allowed clinic patients to add information when they saw doctors who were not affiliated with the clinic, said Martin Harris, the clinic's chief information officer.But Pamela Hartzband and Jerome Groopman, both from Harvard University, complained in the New England Journal of Medicine in April (2008;358:1656-8) that electronic health records have led to a sea of results being pasted from previous records, instead of being focused and selective.Furthermore, they said that electronic records have "become a powerful vehicle for per-Fears over security as Google launches free electronic health records service for patients UK NEWS Finding a solution to hospital associated infections, p 1210 World NEWS Italian police arrest drug officials over alleged falsification of data, p 1208 bmj.com
Diaphragmatic eventration in infants
Authors: F. Paris, E. Blasco, A. Canto, V. Tarazona, M. Casillas
Journal: Thorax (1973)

Nine cases of diaphragmatic eventration are presented in infants, seven of whom required surgery. All were seen during the first 19 months of life and seven were less than 1 year old. Although differing from other studies, our cases show a predominance of right-sided lesions. Respiratory symptoms were present in most cases, and digestive symptoms appeared in a lesser number of cases. The radiological changes were pronounced in seven of the nine cases, the dome of the diaphragm reaching to the fourth to fifth intercostal spaces. Regarding surgical technique, the authors favour diaphragmatic plication through the thorax. This gave excellent clinical and radiological results and was without mortality or complications.
Abstract 1493: High-resolution comparative genomic hybridization of preneoplastic and invasive esophageal squamous cell carcinoma: Identification of the earliest preneoplastic changes
Authors: Jonathan Keith Killian, Mark J. Roth, Parvati D. Singh, Robert Walker, Jack Zhu, Miia Suuriniemi, Yidong Chen, Guo-Qing Wang, Nan Hu, Philip R. Taylor, You-Lin Qiao, Sanford M. Dawsey, Paul S. Meltzer
Journal: Cancer Research (2010)

Abstract Background: Esophageal cancer causes &amp;gt; 400,000 deaths/year in the world. Clinically useful early detection methods must identify these cancers and their precursor lesions at more curable stages. We conducted comparative genomic hybridization analyses of preneoplastic and invasive esophageal squamous cell carcinoma to look for gene copy number patterns that might be useful as early detection markers. The current effort focuses on aberrations associated with mild squamous dysplasia, the earliest histologic form of squamous preneoplasia. Methods: DNA was extracted from either biopsies or surgical resections from 122 esophageal tissues spanning a spectrum including normal mucosa, squamous preneoplasia, and invasive squamous cell carcinoma. High-resolution micro-array based comparative genomic hybridization (Agilent) was used to measure regions of chromosomal gain or loss with an emphasis on identifying changes associated with the transition from normal to mild dysplasia. Results: Chromosomal number aberrations were identified that involve several chromosomes, occur early in the neoplastic process, and progress with disease severity. Specific chromosomal number aberrations associated with mild squamous dysplasia, the earliest form of squamous preneoplasia, were uniquely identified. Conclusions: Comparative genomic hybridization identifies patterns of chromosomal number aberrations that may distinguish patients with and without high-grade squamous dysplasia or cancer. The current effort also identifies specific changes associated with mild squamous dysplasia, the earliest form of preneoplasia, and this may help elucidate mechanisms related to the initiation of carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1493.
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
Authors: Kim De Keersmaecker, Zeynep Kalender Atak, Ning Li, Carmen Vicente, Stephanie Patchett, Tiziana Girardi, Valentina Gianfelici, Ellen Geerdens, Emmanuelle Clappier, Michaël Porcu, Idoya Lahortiga, Rossella Lucà, Jiekun Yan, Gert Hulselmans, Hilde Vranckx, Roel Vandepoel, Bram Sweron, Kris Jacobs, Nicole Mentens, Iwona Wlodarska, Barbara Cauwelier, Jacqueline Cloos, Jean Soulier, Anne Uyttebroeck, Claudia Bagni, Bassem A Hassan, Peter Vandenberghe, Arlen W Johnson, Stein Aerts, Jan Cools
Journal: Nature Genetics (2012)
Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure☆
Authors: Christen Peder Dahl, Lars Gullestad, Børre Fevang, Are M. Holm, Linn Landrø, Leif Erik Vinge, Arnt E. Fiane, Wiggo J. Sandberg, Kari Otterdal, Stig S. Frøland, Jan Kristian Damås, Bente Halvorsen, Pål Aukrust, Erik Øie, Arne Yndestad
Journal: European Journal of Heart Failure (2008)
Engineering and physiological approaches to the study of cardiovascular function: science and pseudoscience?
Authors: G. Wright
Journal: Cardiovascular Research (1992)

Journal Article Engineering and physiological approaches to the study of cardiovascular function: science and pseudoscience? Get access Gordon Wright Gordon Wright Department of Biological Sciences, University of Keele, Staffordshire ST5 5BG, United Kingdom Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 3, March 1992, Pages 215–217, https://doi.org/10.1093/cvr/26.3.215 Published: 01 March 1992
Doctors and managers need to speak a common language
Authors: R. A Atun
Journal: BMJ (2003)

Changes in the NHS since the 1980s have resulted in a systematic shift of control away from clinicians to managers. This has led to a doctor-manager divide and an unhealthy “them and us” culture. Unsystematic efforts to bridge this divide have had limited success. New approaches are therefore necessary.

Most doctors have little involvement in management, perceiving that it conflicts with professional duties and adds unnecessary work. Those who are willing to participate are prevented by a lack of formal management training. The most important barrier is …
Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment
Authors: Elena Garralda, Keren Paz, Pedro P. López-Casas, Siân Jones, Amanda Katz, Lisa M. Kann, Fernando López-Rios, Francesca Sarno, Fátima Al-Shahrour, David Vasquez, Elizabeth Bruckheimer, Samuel V. Angiuoli, Antonio Calles, Luis A. Diaz, Victor E. Velculescu, Alfonso Valencia, David Sidransky, Manuel Hidalgo
Journal: Clinical Cancer Research (2014)

Current technology permits an unbiased massive analysis of somatic genetic alterations from tumor DNA as well as the generation of individualized mouse xenografts (Avatar models). This work aimed to evaluate our experience integrating these two strategies to personalize the treatment of patients with cancer.We performed whole-exome sequencing analysis of 25 patients with advanced solid tumors to identify putatively actionable tumor-specific genomic alterations. Avatar models were used as an in vivo platform to test proposed treatment strategies.Successful exome sequencing analyses have been obtained for 23 patients. Tumor-specific mutations and copy-number variations were identified. All samples profiled contained relevant genomic alterations. Tumor was implanted to create an Avatar model from 14 patients and 10 succeeded. Occasionally, actionable alterations such as mutations in NF1, PI3KA, and DDR2 failed to provide any benefit when a targeted drug was tested in the Avatar and, accordingly, treatment of the patients with these drugs was not effective. To date, 13 patients have received a personalized treatment and 6 achieved durable partial remissions. Prior testing of candidate treatments in Avatar models correlated with clinical response and helped to select empirical treatments in some patients with no actionable mutations.The use of full genomic analysis for cancer care is encouraging but presents important challenges that will need to be solved for broad clinical application. Avatar models are a promising investigational platform for therapeutic decision making. While limitations still exist, this strategy should be further tested.
The Morphologic Effects of Oral Contraceptive Agents on the Cervix
Authors: Stanley A. Gall
Journal: JAMA (1969)

Clinical evaluation of the pelvis, Papanicolaou smears, and histologic review of cervical biopsy specimens in 103 patients were used to study the effects of oral contraceptive agents on the cervix. No patient was found to have carcinoma, but a clinical lesion was present in 84% of the patients. Reactivity of the cervix to contraceptive agents as judged by several histologic criteria increases as continuous use of the contraceptive agent increases; however, cervical reactivity is decreased in older women. Combination contraceptive agents caused greater histologic change than sequential agents.
Sutureless Skin Closure
Authors: G. Qvist
Journal: BMJ (1963)

BmDIC ¶sHand a small outbreak was recorded in Bristol in 1961 2 A week ago two cases were seen in Bristol, and within the last ten days at least 20 cases have occurred in a small area of Buckinghamshire.A very similar outbreak has occurred in Swindon involving about the same numbers.Recent observations suggest that some patients in these outbreaks may only suffer from mouth ulcers, and this fact and the mildness of the condition may not cause it to be recognized immediately.It seems, however, that the disease may well be occurring in many different parts of the country, and it would be of interest to hear of further outbreaks that have occurred.-Weare, etc.,
Discovery of a Linear Peptide for Improving Tumor Targeting of Gene Products and Treatment of Distal Tumors by IL-12 Gene Therapy
Authors: Jeffry Cutrera, Denada Dibra, Xueqing Xia, Azeem Hasan, Scott Reed, Shulin Li
Journal: Molecular Therapy (2011)

Like many effective therapeutics, interleukin-12 (IL-12) therapy often causes side effects. Tumor targeted delivery may improve the efficacy and decrease the toxicity of systemic IL-12 treatments. In this study, a novel targeting approach was investigated. A secreted alkaline phosphatase (SEAP) reporter gene-based screening process was used to identify a mini-peptide which can be produced in vivo to target gene products to tumors. The coding region for the best peptide was inserted into an IL-12 gene to determine the antitumor efficacy. Affinity chromatography, mass spectrometry analysis, and binding studies were used to identify a receptor for this peptide. We discovered that the linear peptide VNTANST increased the tumor accumulation of the reporter gene products in five independent tumor models including one human xenogeneic model. The product from VNTANST-IL-12 fusion gene therapy increased accumulation of IL-12 in the tumor environment, and in three tumor models, VNTANST-IL-12 gene therapy inhibited distal tumor growth. In a spontaneous lung metastasis model, inhibition of metastatic tumor growth was improved compared to wild-type IL-12 gene therapy, and in a squamous cell carcinoma model, toxic liver lesions were reduced. The receptor for VNTANST was identified as vimentin. These results show the promise of using VNTANST to improve IL-12 treatments.
Myxoma of the Left Atrium
Authors: David L. Chamovitz
Journal: JAMA (1962)

RECOGNITION of the syndrome caused by myxoma of the left atrium is of the utmost importance now that surgery offers the opportunity for complete cure. In most instances, the disease is confused with more common cardiac disorders. To serve as a reminder, the following case report is added to the literature. Clinical Summary A 59-year-old woman was admitted to the Aliuippa Hospital on July 4, 1957, because of congestive heart failure. She had been well until 10 months previously, when, mowing her lawn, she developed severe pain in the anterior chest and left arm, associated with profuse perspiration and dyspnea. Because of the possibility of a myocardial infarction, she was hospitalized from Aug. 31 to Sept. 26, 1956. Blood pressure was 120/80 mm. Hg, and cardiac examination, including roentgen study, was normal. Electrocardiograms were normal with a Q wave of questionable significance in aVL. Hemoglobin was 9.5 gm.%; white blood-cell
Learning the Value of Drugs — Is Rofecoxib a Regulatory Success Story?
Authors: Rebecca S. Eisenberg
Journal: New England Journal of Medicine (2005)

Controversy over recent revelations concerning the adverse cardiovascular effects of selective cyclooxygenase-2 (COX-2) inhibitors has generally been framed as a story of regulatory failure, in which the Food and Drug Administration (FDA) has failed in its mission to protect the public from unsafe products. But this simplistic understanding of the mission of the FDA seems to make failure all but inevitable, if the reliable observation of the risks and benefits of a drug requires rigorous long-term studies. Perhaps in an earlier era the goal of drug regulation was simply to protect the public from poisons.1 Today, drug regulation guides the . . .
PERIMETRIC OBSERVATIONS ON THE INFLUENCE OF ESERINE AND IRIDECTOMY IN CHRONIC GLAUCOMA.Read in the Section of Ophthalmology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: G. E. DE SCHWEINITZ
Journal: JAMA (1891)

The best treatment for chronic glaucoma has often been discussed, but even at this time con- siderable difference of opinion exists in regard to the most satisfactory method, while the progno- sis of the disease, depending as it does upon many factors, is always a doubtful quantity even after the most skilfully performed surgical inter- ference.Most surgeons will, I think, subscribe to the doctrine of Dr. Bull, who says, "It seems to be our duty to operate in cases of chronic pro- gressive glaucoma, and the earlier the better."It is presupposed that the patient has previously been warned of the nature of this disease to pro¬ gress towards blindness and, as Priestley Smith has said, of the uncertainties which beset the op¬ eration.When a case of chronic glaucoma is under observation and the surgeon is weighing the chances for and against operation, it becomes necessary not merely to test the acuity of vision, but to have frequent information in regard to the field of vision, although, no doubt, it is perfect¬ ly true, as Dr. Bull further has said, that the condition of the field of vision is no constant guide either in forming a prognosis as to the progress of the disease or in deciding as to the time of operation.The picture of chronic glau¬ coma is a very familiar one, and we are all famil¬ iar with the so-called simple varieties of the dis¬ ease in which the front of the eye exhibits prac¬ tically no signs of disease, the anterior chamber may be of good depth and the iris prompt in its reactions to light and myotics, in which there is sometimes never any perceptible increase of ten¬ sion, or this is only temporary in its character, but in which there is a shallow excavation of the disc, glaucomatous in its type, some decrease in vision, and contraction of the field.Since the
Thomas Henry Eustace
Authors: J. Eustace
Journal: BMJ (2003)

Former general practitioner and coroner Drayton Valley, Alberta, Canada (b Chelmsford, Essex, 1917; q Guy's Hospital, London, 1944), died on 23 December 2002 after a stroke.

Tom served with the Royal Navy during the second world war. He later joined a practice in a small village in Suffolk, England, and in 1952 became a founding member of the Royal College of General Practitioners. In 1966 he moved to a small town in Alberta, Canada. During his 30 years of practice there he served as chief of staff for the hospital and coroner for the region, and had a special interest in obstetrics and gynaecology. He loved outdoor activities and was an avid fisherman. He leaves a wife, Ann; three sons; and 10 grandchildren.
NIH: An Account of Research in Its Laboratories and Clinics
Authors: Lawrence D. Grouse
Journal: JAMA (1985)

This volume demonstrates the central role of the intramural program of the National Institutes of Health (NIH) in sowing the seeds of science in US medicine. The scope of medical discovery accomplished by this venerable institution is remarkable. And, since medical advances may be among the most important legacies of US culture, a detailed reminiscence about research at the NIH is both inspiring and instructive.  The authors of the 44 essays that make up the book have impeccable scientific credentials. Each has led major research programs. Their abilities to narrate a history of scientific investigation in their specialties vary, however. Many of the essays are tedious recitations of countless names and details with little sense of the achievement and the drama of the research. Generally, there is an inverse relationship between the length of the essay and its merit. Even Nobel laureates and other geniuses can be boring.  Still, the
A Fourth Cataractous Family.
Authors: John L. Dicky
Journal: JAMA (1904)

Wheeling, W. Va., June 22, 1904. <h3>To the Editor:</h3> —InThe Journal, March 4, 1899, I reported "A Third Cataractous Family." I wish now to record what would seem to be another instance of hereditary tendency to cataract. On May 31, 1904, assisted by Dr. Bessie Hewetson, St. Clairsville, Ohio, who afterward sent me these notes, I removed a mature cataract from the eye of R. H. A., aged 74 years. His sister, now in her 82d year. has been blind in one eye from cataract for several years. His father died at 77. and had been blind from cataract for several years. One eye was operated on one year before his death. A sister of his father was also blind from cataract for several years before her death. She lived to be about the same, age.