tbuckley/cabot-search huggingface dataset:
Representation of Special Groups on C.C. and S. Committee
Authors: P. Hall-Smith
Journal: BMJ (1967)

those making impulsive suicidal attempts.By the time a sufficient dose of the analgesic drug has been extracted from its wrappings some of the emotional heat might have been dissipated, allowing time for wiser counsels to prevail.It is so very much easier to open a bottle of tablets and swallow the lot in one impulsive gesture than it is to unwrap labori- ously each pill carefully embedded in tinfoil.We would like to suggest, therefore, as a contribution to lessening the self-poisoning problem, that the drug firms should be asked to consider whether it would be possible to market all sedative and hypnotic drugs in this individually wrapped fashion.We do not know how such packaging compares in cost with the more conventional methods of supply in cartons and bottles, but it is possible that any additional cost would be more than compensated for by the saving of lives and expensive hospital treatment.-We are, etc.,
RESISTANT PSYCHOSIS TREATED SUCCESSFULLY BY INDOKLON(1, 2, 3)
Authors: IRVING D. ROSENBERG
Journal: American Journal of Psychiatry (1962)

A case is presented in which a patient's delusions, which had been resistant to ECT and tranquilizers, cleared up rapidly after only one Indoklon treatment. Indoklon, therefore, is an important somatic treatment in psychiatry because, although it is not yet generally available(6), it has distinct advantages: it is preferred over ECT by most patients(3), it does not require a long course of treatment or costly hospitalizations (3), it can be done as an outpatient or office procedure, it is safer than ECT(1, 2), and, as shown by this report, it is of dramatic benefit in some cases resistant to other forms of psychiatric treatment. The cooperation of the Medical Research Foundation of Philadelphia in providing the Indoklon used in this study is gratefully acknowledged.
Prognostic Index for 4-Year Mortality in Older Adults
Authors: Anton J. M. de Craen, Rudi G. J. Westendorp
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early and Significant Improvement In The Intensity Of Allergic Rhinitis Symptoms After Treatment With Intranasal Ciclesonide 200 Mcg Qd: Open Trial In Mexican Population
Authors: Francisco Javier Saynes-Marin, Araceli Arellano-Plancarte, Jazmin Chiu-Ugalde, Estefania Torres-Medina, Jose Antonio Vargas-Romero, Juan Carlos López-Alvarenga
Journal: Journal of Allergy and Clinical Immunology (2014)
Reviews and Notes: Cardiology: Prognosis and Risk Assessment in Cardiovascular Disease
Authors: Harvey Wolinsky
Journal: Annals of Internal Medicine (1994)

Literature of Medicine1 January 1994Reviews and Notes: Cardiology: Prognosis and Risk Assessment in Cardiovascular DiseaseHarvey Wolinsky, MD, PhDHarvey Wolinsky, MD, PhDMt. Sinai Medical Center, New York, NY 10129Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-1-199401010-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Prognosis and Risk Assessment in Cardiovascular DiseaseAmar S. Kapoor and Bramah N. Singh; eds. 578 pages. New York: Churchill Livingstone; 1993. $79.95.What makes a great clinician? No one sees enough cases to be self-sufficient. Rather, we must remain scholars, reading widely and constantly, benefiting from the accumulated experiences of our colleagues, particularly when based on prospective observations of large groups of patients followed for years.Including risk assessment and prognosis for major cardiovascular entities in a single textbook is a highly attractive concept, and the editors are to be lauded for attempting this. In some aspects, they succeed ... Author, Article, and Disclosure InformationAffiliations: Mt. Sinai Medical Center, New York, NY 10129 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1994Volume 120, Issue 1Page: 95KeywordsClinical trialsCoronary artery bypass graftingMedical risk factorsPeripheral vascular diseaseRisk assessmentsThalliumValve replacementValvular diseasesVascular diseasesVentricular premature beat ePublished: 15 August 2000 Issue Published: 1 January 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Body surface mapping of high-frequency components in the terminal portion during QRS complex for the prediction of ventricular tachycardia in patients with previous myocardial infarction.
Authors: T Shibata, I Kubota, K Ikeda, K Tsuiki, S Yasui
Journal: Circulation (1990)

To study the clinical significance of terminal QRS high-frequency components for the prediction of ventricular tachycardia, an 87-lead body surface signal-averaged mapping was performed in 21 healthy subjects (control) and in 41 patients with previous myocardial infarction (anterior, 20; inferior, 21). Mapping data were analyzed and averaged (129.7 +/- 26.5 beats) for 160 seconds, and the signal-averaged beat was filtered with a bidirectional bandwidth (80-250 Hz) digital filter. J-point was determined from the 87-lead RMS voltage of nonfiltered QRS. For each lead, we calculated the sum of the absolute value of filtered QRS from 20 msec ahead of the J-point to the J-point (A-20). The body surface distribution of A-20 was expressed as A-20 map. The maxima in A-20 maps were mainly located on the upper sternal region in healthy subjects, on the left anterior chest in patients with previous anterior myocardial infarction, and on the central anterior chest in patients with previous inferior myocardial infarction. In the patients in both the group with anterior myocardial infarction and the group with inferior myocardial infarction, the value of maximum was significantly greater than in the subjects in the control group (0.181 +/- 0.086 and 0.138 +/- 0.048, respectively, vs. 0.075 +/- 0.031 mV.msec; p less than 0.01). In patients with myocardial infarction (n = 41), the value of maximum was significantly greater with ventricular tachycardia (n = 11) than without ventricular tachycardia (n = 30) (0.240 +/- 0.076 vs. 0.130 +/- 0.043 mV.msec; p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Book: Blind Eye: How the Medical Establishment Let a Doctor get away with Murder
Authors: D. Woods
Journal: BMJ (2000)

James B Stewart Simon and Schuster, £17.91, pp 334 ISBN 0 671 04421 4 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> There is ample precedent for physicians flouting the Hippocratic admonition, “First, do no harm,” and, directly or indirectly, accounting for multiple deaths. Dr Joseph Mengele's handiwork has been much documented; more vicariously, Dr Joseph Guillotin's inventiondid away with a fair number of folk, as did Dr Richard Gatling's gun, which fired 350 shots a minute. But Dr Michael Swango, the subject of this meticulously researched and highly readablebook, was a fully fledged psychopath who killed for the sheer thrill of it. And … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
mechanism of the excessive sedative response of cirrhotics to benzodiazepines: Model experiments with triazolam
Authors: GÜL Bakti, Hans U. Fisch, Georg Karlaganis, Christoph Minder, Johannes Bircher
Journal: Hepatology (1987)

Mechanisms responsible for disproportional sedation resulting from triazolam administration to patients with cirrhosis were investigated. Ordinary sedative doses (0.25 mg) were given p.o. to 8 cirrhotics and 18 controls. Plasma concentrations of unbound drug were assessed by capillary gas chromatography and equilibrium dialysis. Median apparent oral clearances of unbound triazolam were 14.8 ml per min per kg in cirrhotics and 23.9 ml per min per kg in controls (p &lt; 0.01). Clearances were significantly correlated with severity of liver disease as assessed by the aminopyrine breath test (Rs = 0.77, n = 17, p &lt; 0.001). At a time when plasma concentrations of unbound triazolam were the same in both groups, i.e., 2.25 hr after dosing, flicker sensitivity at 5 Hz which was used as an index of CNS performance was impaired by a factor of 3.2 in cirrhotics and 1.4 in controls (p &lt; 0.01 for group difference). Performance was also significantly lower in cirrhotics with the digit symbol substitution test (p &lt; 0.05). It is concluded that, in patients with cirrhosis, disproportional sedation after benzodiazepine administration may be due not only to impaired drug elimination, but also to hypersensitivity of the brain.
Hospital pharmacy committees in England: Their structure, function, and development.
Authors: A W Brown, C W Barrett, A Herxheimer
Journal: BMJ (1975)

A total of 150 chief and group chief pharmacists in England took part in a survey of the structure and role of pharmacy committees in hospitals. Just over half of the hospitals had such a committee. About two-thirds of these dealt only with pharmacy matters and one-third dealt also with other matters. The number of new committees set up increased slowly until 1967 and then showed a sharp rise. Their terms of reference, membership, and manner of appointment varied greatly. Among subjects dealt with the cost of drugs and the introduction of new prescribing sheets were prominent. Many of the respondents believed that the work of the committees, often with the help of smaller, more specialized groups, had significantly improved various aspects of the local supply and use of drugs.
831. Apoptosis Induced by Oncolytic M Protein Mutant Vesicular Stomatitis Virus Is Dependent on PKR, Fas, and Daxx
Authors: Daniel F. Gaddy, Douglas S. Lyles
Journal: Molecular Therapy (2006)

Matrix (M) protein mutants of vesicular stomatitis virus (VSV) that fail to suppress host interferon (IFN) responses are promising oncolytic agents for cancer therapy. In contrast to viruses with wild-type M protein, which induce apoptosis primarily through mitochondrial pathways, M protein mutant VSV induces apoptosis primarily through death receptor pathways. Furthermore, apoptosis induced by M protein mutant VSV involves induction of expression of many proapoptotic genes that are suppressed during infection with viruses containing wild-type M protein. Previous research has implicated Fas (CD95) and protein kinase R (PKR) in activation of death receptor pathways by other viruses. Here we show that apoptosis induced by an M protein mutant VSV was inhibited by expression of dominant-negative mutants of Fas and PKR. Most previous research has focused on the adapter protein FADD as a necessary transducer of Fas-mediated cell death. However, expression of dominant-negative mutant FADD had little effect on induction of apoptosis by M protein mutant VSV. Instead, virus- induced apoptosis was inhibited by expression of a dominant-negative mutant of an alternative adapter protein Daxx. These data indicate that Daxx is more important than FADD for apoptosis induced by M protein mutant VSV. These results show that PKR- and Fas-mediated signaling play important roles in cell death during M protein mutant VSV infection, and that Daxx has novel functions in the host response to virus infection by mediating virus-induced apoptosis.
Update in Hematology: Evidence Published in 2014
Authors: Alice D. Ma
Journal: Annals of Internal Medicine (2015)

Updates5 May 2015Update in Hematology: Evidence Published in 2014Alice D. Ma, MDAlice D. Ma, MDFrom the University of North Carolina, Chapel Hill, North Carolina.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0271 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This update reviews articles on benign and malignant hematologic conditions published in 2014 that the author considers important and relevant to practicing internists. In addition to the articles discussed below, it is worth noting that in 2014, the American Society of Hematology published its second “Choosing Wisely” list (1). The Society has added 5 commonly used tests, treatments, and procedures in hematology that might not always be necessary.In the field of malignant hematology, a new agent, idelalisib, was added to rituximab to treat frail, elderly, pretreated patients with chronic lymphocytic leukemia, a disease seen more commonly in internal medicine ...Reference1. Hicks LK, Bering H, Carson KR, Haynes AE, Kleinerman J, Kukreti V, et al. Five hematologic tests and treatments to question. Blood. 2014;124:3524-8. [PMID: 25472968] doi:10.1182/blood-2014-09-599399 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of North Carolina, Chapel Hill, North Carolina.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-0271.Corresponding Author: Alice D. Ma, MD, Division of Hematology/Oncology, University of North Carolina, 170 Manning Drive, CB #7305, Chapel Hill, NC 27599; e-mail, [email protected]unc.edu.Author Contributions: Conception and design: A.D. Ma.Analysis and interpretation of the data: A.D. Ma.Drafting of the article: A.D. Ma.Critical revision of the article for important intellectual content: A.D. Ma.Final approval of the article: A.D. Ma.Administrative, technical, or logistic support: A.D. Ma.Collection and assembly of data: A.D. Ma.This article was published online first at www.annals.org on 30 April 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 May 2015Volume 162, Issue 9Page: W106-W110KeywordsHematology and oncologyHemoglobinHemorrhageRed blood cellsSafety ePublished: 5 May 2015 Issue Published: 5 May 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
A Novel Model of SCID-X1 Reconstitution Reveals Predisposition to Retrovirus-induced Lymphoma but No Evidence of γC Gene Oncogenicity
Authors: Linda Scobie, Ralph D Hector, Louise Grant, Margaret Bell, Anne A Nielsen, Sharon Meikle, Adrain Philbey, Adrain J Thrasher, Ewan R Cameron, Karen Blyth, James C Neil
Journal: Molecular Therapy (2009)

The emergence of leukemia following gene transfer to restore common cytokine receptor γ chain (γC) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncogenic potential of human γC in new strains of transgenic mice expressing the gene under the control of the CD2 promoter and locus control region (LCR). These mice demonstrated mildly perturbed T-cell development, with an increased proportion of thymic CD8 cells, but showed no predisposition to tumor development even on highly tumor prone backgrounds or after γ-retrovirus infection. The human CD2-γC transgene rescued T and B-cell development in γC−/− mice but with an age-related delay, mimicking postnatal reconstitution in SCID-X1 gene therapy subjects. However, we noted that γC−/− mice are acutely susceptible to murine leukemia virus (MLV) leukemogenesis, and that this trait was not corrected by the γC transgene. We conclude that the SCID-X1 phenotype can be corrected safely by stable ectopic expression of γC and that the transgene is not significantly oncogenic when expressed in this context. However, an underlying predisposition conferred by the SCID-X1 background appears to collaborate with insertional mutagenesis to increase the risk of tumor development. The emergence of leukemia following gene transfer to restore common cytokine receptor γ chain (γC) function in X-linked severe combined immunodeficiency (SCID-X1) has raised important questions with respect to gene therapy safety. To explore the risk factors involved, we tested the oncogenic potential of human γC in new strains of transgenic mice expressing the gene under the control of the CD2 promoter and locus control region (LCR). These mice demonstrated mildly perturbed T-cell development, with an increased proportion of thymic CD8 cells, but showed no predisposition to tumor development even on highly tumor prone backgrounds or after γ-retrovirus infection. The human CD2-γC transgene rescued T and B-cell development in γC−/− mice but with an age-related delay, mimicking postnatal reconstitution in SCID-X1 gene therapy subjects. However, we noted that γC−/− mice are acutely susceptible to murine leukemia virus (MLV) leukemogenesis, and that this trait was not corrected by the γC transgene. We conclude that the SCID-X1 phenotype can be corrected safely by stable ectopic expression of γC and that the transgene is not significantly oncogenic when expressed in this context. However, an underlying predisposition conferred by the SCID-X1 background appears to collaborate with insertional mutagenesis to increase the risk of tumor development.
The role of plasma biomarkers in acute heart failure. Serial changes and independent prognostic value of NT‐proBNP and cardiac troponin‐T
Authors: Marco Metra, Savina Nodari, Giovanni Parrinello, Claudia Specchia, Loretta Brentana, Patrizia Rocca, Francesco Fracassi, Tania Bordonali, Patrizia Milani, Rossella Danesi, Giulia Verzura, Ermanna Chiari, Livio Dei Cas
Journal: European Journal of Heart Failure (2007)
Internal Medicine and the Journey to Medical Generalism
Authors: Marc L. Rivo
Journal: Annals of Internal Medicine (1993)

The overspecialized U.S. physician workforce and mix of graduating residents undermine strategies to provide quality and affordable health care to all Americans. Several respected advisory bodies have recently proposed fundamental changes in federal policy to better match physician supply and specialty mix with health care needs. They recommend that Congress limit the total number of filled first-year resident positions to 110% of the number of U.S. medical school graduates, a 20% reduction from current levels. They have proposed that positions and funding be allocated to medical schools, teaching hospitals, residency programs, or consortia of such entities to ensure that at least 50% of each graduating residency class enters generalist practice. An all-payer, graduate medical education pool and financing system have been suggested as ways to uncouple the physician workforce from hospital service needs and to eliminate disincentives toward ambulatory and primary care training. Increases in generalist production must be accompanied by decreases in nonprimary care specialty and subspecialty positions. In addition, generalist physicians must be better prepared in managed care competencies. Given today's subspecialist surplus, managed care organizations are considering how to retrain subspecialists as generalists. The Federated Council of Internal Medicine's goal that 50% of its graduates become general internists is an important step because internists compose one sixth of all physicians and one third of all first-year residents. This article identifies the challenges that lay ahead on the road to medical generalism and what it may take to get there.
Bury Me as a Pipe Smoker
Authors: Larry R. Kirkland
Journal: JAMA (1992)

To the Editor.  —As a  smoker who rarely smokes in company, I take some umbrage at Dr Tuteur's rather opinionated reply in the Question and Answers section of a recent issue ofJAMA.1A simple no hard data exist would have answered the question more truthfully. To state that pipe smokers' risk of death due to pulmonary carcinoma is intermediate between those of never  and cigarette smokers stretches the definition of intermediate (which is defined as lying or being in the middle place or degree, according toWebster's). As Tuteur knows, the risk of pulmonary carcinoma in   is much closer to the never  and far from the cigarette smokers. Though the degree of inhalation is undoubtedly important, it is unlikely that all types of tobacco smoke (regardless of source) are equally dangerous. For reasons not yet elucidated, cigarette smoke is much the greater
Prevalence of Diabetes and Impaired Glucose Tolerance Among Navajo Indians
Authors: Jonathan R Sugarman, Timothy J Gilbert, Noel S Weiss
Journal: Diabetes Care (1992)

To estimate the prevalence of diabetes mellitus and impaired glucose tolerance and the incidence of clinically diagnosed diabetes in a community of Navajo Indians.We conducted a survey of a representative Navajo community screened for diabetes 3 yr previously. We used 75-g oral glucose tolerance tests to determine the prevalence of diabetes mellitus and impaired glucose tolerance and conducted medical record reviews to identify cases of diabetes that were diagnosed during routine medical care after the earlier study.By World Health Organization diagnostic criteria, the age-adjusted diabetes prevalence among 419 Navajo Indians 20-74 yr of age was 13.9% (95% confidence interval [CI] 9.2-18.5) for men and 18.4% (95% CI 14-22.8) for women. The ratio of the prevalence of diabetes among the Navajo population studied to that in the general United States population was 2.5. The prevalence of impaired glucose tolerance was 8% (95% CI 3.3-12.7) among men and 12.9% (95% CI 7.9-17.9) among women. Based on clinical diagnoses of diabetes made during routine medical care, mean +/- SE age-adjusted incidence of diagnosed diabetes among men was 8.6 +/- 4.3/1000 person-yr and 11.1 +/- 4.4/1000 person-yr among women.Although lower than that of some other tribes, the prevalence of diabetes among Navajo Indians is substantially higher than that in the general U.S. population. The high rate of clinical diagnoses suggests that the prevalence of the disease may continue to rise.