tbuckley/cabot-search huggingface dataset:
The effect of house dust mite sensitization on lung size and airway caliber in symptomatic and nonsymptomatic preadolescent children: a community-based study in Poland.
Authors: Wieslaw Jedrychowski, Umberto Maugeri, Iwona Jedrychowska-Bianchi, Elzbieta Mróz
Journal: Environmental Health Perspectives (2002)

There are conflicting reports on the effects of atopy on lung function. The purpose of this study was to compare the effects of house mite (HM) atopy on lung function in subsamples of 12-year-old symptomatic and nonsymptomatic preadolescent children taken from the community sample. An additional objective of this study was to identify possible environmental determinants of HM skin reaction. We obtained questionnaire data on respiratory symptoms and skin-prick tests and performed spirometry on a subsample of 311 children of a birth cohort of children who have been followed over 3 years. Multivariate regression analysis showed progressive decrement of lung function indices (forced vital capacity, forced expiratory volume in 1 sec, and forced expiratory flow, midexpiratory phase) with increasing degree of HM atopy reflected by the skin reaction to HM allergens. The apparent association between the level of HM atopy and the lung function indices was highly significant in symptomatic individuals but insignificant in nonsymptomatic subjects. HM sensitization was significantly associated with mother's atopy. It occurred predominantly in boys and was related to the use of coal or gas for house heating. The effect of allergen sensitization on lung size and airway caliber confined to symptomatic subjects may reflect the inflammatory status of bronchial airways in the symptomatic subjects.
Physicians in Partnership
Authors: —Nick G. Onychuk
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
924 INCREASING RATES OF HBsAg CLEARANCE AND SEROCONVERSION IN PATIENTS WITH HBeAg-NEGATIVE DISEASE TREATED WITH PEGINTERFERON ALFA-2A ± LAMIVUDINE: RESULTS OF 5-YEAR POST-TREATMENT FOLLOW UP
Authors: P. Marcellin, T. Piratvisuth, M. Brunetto, F. Bonino, G.K.K. Lau, P. Farci, C. Yurdaydin, S. Gurel, J. Wu, M. Popescu
Journal: Journal of Hepatology (2009)
Ascorbic Acid Depletion During Hemodialysis
Authors: John F. Sullivan
Journal: JAMA (1972)

Sixteen patients receiving long-term hemodialysis therapy demonstrated a decline in leukocyte ascorbic acid concentration of 26% during a single hemodialysis. Eight patients receiving 1 gm of ascorbic acid by mouth showed a 76% rise in leukocyte ascorbic acid concentration in three hours, while control subjects showed a 5% increase. When ascorbic acid was added to dialysate baths of 12 patients, plasma ascorbate levels were elevated by 26% at the end of dialysis, and leukocyte levels rose by 11%. Short-term hemodialysis therapy over five consecutive days produced a continuous decline in plasma and leukocyte ascorbate levels. Ascorbic acid loss from leukocytes and plasma during hemodialysis can be prevented by the addition of the vitamin to dialysate concentrate.
TGF-&amp;bgr;/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammation
Authors: Claudio Fiocchi
Journal: Journal of Clinical Investigation (2001)

The immune system normally defends the body against the constant threat of myriad organisms and substances in the surrounding environment. In some individuals immune reactivity becomes inappropriate or excessive, and autoimmune or chronic inflammatory diseases ensue, which usually persist for most of the patient’s life. While chronic inflammation can affect practically any organ, this process is distinctive in the gastrointestinal tract: Whereas most organs contain only a sprinkling of immune cells, the normal gut contains a rich lymphoid compartment that maintains a low level of “physiological” intestinal inflammation. Enteric flora and food antigens are believed to induce and sustain this physiological intestinal inflammation that is transformed into destructive and persistent “pathological” inflammation when the gut is involved by Crohn disease (CD), ulcerative colitis (UC), or other forms of chronic inflammatory bowel disease (IBD).
Meeting the Survival Needs of the World's Least Healthy People
Authors: Lawrence O. Gostin
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
O29 ALTERED MITOCHONDRIA IN LIVER-SPECIFIC PROHIBITIN-2 NULL MICE INDUCES HEPATIC DAMAGES ASSOCIATED WITH STEATOSIS AND IMPAIRED GLUCONEOGENESIS
Authors: J. Martin-Levilain, S. Supale, C. Merkwirth, D. Metzger, P. Chambon, T. Langer, P. Maechler
Journal: Journal of Hepatology (2014)
Abstract P6-05-24: Expression of aquaporin 5 and its polymorphisms predict survival in patients with early breast cancer
Authors: SJ Lee, YS Chae, HY Park, JH Jung, WW Kim, J-Y Park, JY Jeong
Journal: Cancer Research (2013)

Abstract Background. Our previous study showed the association of AQP5 up-regulation with cancer proliferation and migration in hormone-responsive breast cancer cell lines (MCF-7) and with unfavorable prognosis in a small number of patients with breast cancer. Accordingly, we analyzed the prognostic impact of AQP5 expression and polymorphisms in a large number of patients with early breast cancer (EBC). Methods. AQP5 expression was investigated based on the immunohistochemistry of tissue microarray specimens from 609 EBC patients who underwent surgery between 2003 and 2008. We scored the staining intensity (IS) and percentage of positive tumor cells (PC). The genomic DNA was extracted from paraffin-embedded tumor-free tissue and then genotyped for 3 polymorphisms (rs3736309, rs1964676, and rs74091167) using the Sequenom Mass array system. Results. Among the 3 polymorphisms, AQP5 overexpression (IS + PC ≥6) was correlated with AQP5 rs74091167 GG genotype. AQP5 overexpression and AQP5 rs74091167 was significantly associated with disease-free survival (DFS; P &amp;lt; 0.001 and P = 0.021, respectively). Moreover, a multivariate survival analysis revealed that AQP5 overexpression and the GG genotype of AQP5 rs74091167 were significantly associated with DFS (HR = 2.026, 95% CI 1.058-3.881, P = 0.030; HR = 0.377, 95% CI 0.179-0.793, P = 0.010, respectively) adjusted to clinicopathological variables, which was prominent in patients with an ER/PgR-positive tumor. Conclusions. Consistent with our previous study of breast cancer cell lines, AQP5 expression and AQP5 rs74091167 variant can be considered as a prognostic marker in patients with EBC after curative surgery. In the future, functional relevance of this variant needs to be clarified. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P6-05-24.
Pulmonary Embolism and Oral Contraceptives
Authors: Paul Goldfinger
Journal: JAMA (1971)

<h3>To the Editor.—</h3> I recently had occasion to observe the case of an 18-year-old girl who died as a result of massive pulmonary embolization. She had been hospitalized because of two fractured transverse lumbar vertebral processes. At absolute bed rest, she was doing well until the ninth hospital day, when she became suddenly hypotensive and died shortly thereafter. An autopsy revealed acute pulmonary embolization, and thrombosis of the hypogastric veins. For 1 1/2 years prior to admission, she had received an oral contraceptive without complication. During her hospital stay she continued to receive this medication. Her past history was otherwise normal with regard to factors predisposing to thromboembolic disorders. Although prolonged immobilization could account for this patient's thrombotic episode, it is also possible that thrombogenic action of the oral contraceptive was contributory. Any woman who is taking "the pill" and who is to be immobilized should stop the medication for
Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin-dependent activation
Authors: Margherita Tomassini, Anne Tsicopoulos, Po Chun Tai, Valérie Gruart, André-Bernard Tonnel, Lionel Prin, Adré Capron, Monique Capron
Journal: Journal of Allergy and Clinical Immunology (1991)
Reactive Lymphoid Hyperplasia of the Liver Identified by FDG PET
Authors: Eugene Lin
Journal: Clinical Nuclear Medicine (2008)

A 44-year-old woman with a history of colon cancer underwent an F-18 fluorodeoxyglucose positron emission tomography (FDG PET) scan to evaluate for recurrence. Intense focal FDG uptake in the caudate lobe was noted, which corresponded to a 1.5-cm lesion on computed tomography. The patient was thought to have a solitary liver metastasis and underwent partial hepatectomy. The FDG-avid lesion was diagnosed as reactive lymphoid hyperplasia of the liver. Although it is a rare lesion, reactive lymphoid hyperplasia of the liver is an important source of false-positive results on FDG PET because it has been associated with carcinomas, in particular colon carcinoma.
1006. Effect on Expression of Including Binding Sites for the ELAV-Like Proteins HuD and HuR in Transgene Cassettes
Authors: Changyu Zheng, Bruce J. Baum
Journal: Molecular Therapy (2006)

ELAV-like (embryonic lethal abnormal vision) proteins are RNA- binding proteins first described in Drosophila. ELAV proteins are necessary for neuronal differentiation and maintenance. The human ELAV-like family includes HuB, HuC, Hel-N1, HuD and HuR and consists of three RNA-recognition motifs through which they bind with high affinity and specificity to target mRNAs with AU-rich elements. HuR is expressed in all cells, while HuD is considered neural specific. To optimize vectors for clinical application, we initially evaluated the expression patterns of several viral and mammalian promoters (Zheng and Baum, Mol. Ther., 2005). Since ELAV-like proteins can regulate mRNA stability and/or translation, we hypothesized that inclusion of binding sites for some ELAV-like proteins in expression cassettes could improve transgene expression. To test this, we selected two such binding sites (from p53 and vascular endothelial growth factor [VEGF]) for HuR, and seven binding sites for HuD (from c-fos, IL-3, c-myc-1, c-myc-2, tau, adenovirus IVa2 and growth-associated protein 43 [GAP-43]). Binding sites were inserted into the pACEF1a-luc-bGH expression plasmid, which includes the human elongation factor 1a (EF1a) promoter, luciferase cDNA (luc) and the bovine growth hormone poly A (bGH) in the expression cassette, between the luciferase cDNA and bGH poly A. The 293 and A5 (rat epithelial) cell lines were transfected with plasmids in vitro with LipofectamineTM 2000. We compared expression from these plasmids to that from expression plasmids containing the common SV40 poly A and either the EF1a or cytomegalovirus (CMV) promoter (pACEF1a-luc and pACCMV-luc; i.e., without any ELAV-like protein binding sites). In 293 cells, 24 or 48 hours post-transfection, pACCMV-luc resulted in 3 - 4 fold higher expression than pACEF1a-luc-bGH without ELAV-like protein binding sites. Addition of the p53 binding site to pACEF1a-luc-bGH increased luciferase expression 20 - 30% in 293 cells. The other ELAV-like protein binding sites either had no effect or decreased luciferase expression in 293 cells. In A5 cells, however, pACEF1a- luc-bGH containing the p53 binding site had the highest luciferase activity 24 or 48 hours post-transfection, markedly higher (2 - 3 fold) than that seen with either pACCMV-luc or pACEF1a-luc. pACEF1a-luc-bGH with binding sites from c-myc-2, VEGF and IL-3 also led to increased luciferase expression (45 - 120%) in A5 cells 48 hours post-transfection. These data support our hypothesis, especially in the A5 rat epithelial cell line. The pACEF1a-luc-bGH plasmids containing p53, c-myc-2, VEGF and IL-3 binding sites will next be tested to see if their beneficial effects are realized in vivo.
High prevalence of hepatitis C virus infection in patients with B-cell lymphoproliferative disorders in Italy
Authors: Gennaro De Rosa, Maria Luisa Gobbo, Amalia De Renzo, Rosario Notaro, Salvatore Garofalo, Maria Grimaldi, Aurora Apuzzo, Federico Chiurazzi, Marco Picardi, Margherita Matarazzo, Bruno Rotoli
Journal: American Journal of Hematology (1997)

Starting from the observation that a number of consecutive patients with non-Hodgkin's lymphoma (NHL) resulted positive for hepatitis C virus (HCV) antibodies on routine testing, we set up a survey for HCV contact prevalence in all patients with lymphoproliferative disorders (LPD) followed in our institution. We searched for HCV antibodies by a third-generation ELISA technique, followed by a confirmation test (RIBA III); serum viral RNA and HCV genotype were investigated by a RT-PCR technique. We screened a total of 315 patients suffering from B-NHL (91), multiple myeloma (56), MGUS (48), chronic lymphocytic leukemia (57), Waldentrom's macroglobulinemia (13), Hodgkin's disease (HD)(43), and T-NHL (9). While only 1 of 52 patients with a non-B-LPD (HD or T-NHL) had signs of HCV contact (i.e., 1.9%, which is in the range of the normal population in the South of Italy), 59 of 263 patients with a B-LPD (22.4%) had HCV antibodies or RNA, or both, with no major differences among the various types of disorders, except for WM, in which the rate was higher (61.5%). The same prevalence was found for patients tested at diagnosis or during the follow-up, and in transfused or never-transfused patients. Only a few patients were aware of having a liver disease; one-half of HCV-positive patients never had transaminase increase. A review of data from Central and Northern Italy is included, showing similar findings; a report from Japan has confirmed such an association, while limited surveys in England have not revealed any correlation. These findings may have important biological and clinical implications.
Gastrin and gastrointestinal disease.
Authors: J J Misiewicz, S L Waller, D J Holdstock
Journal: BMJ (1972)

Gastrin and Gastrointestinal Disease SIR,-We were interested in your leading article on this topic (9 September, p. 604), but we think your statement that gastrin may affect intestinal motility needs qualification.In doses producing near-maximal gastric- acid secretion both gastrin and pentagastrin were found to stimulate motility in the gastric antrum, but no effect on colonic motor activity could be detected.1 2 As you point out, serum gastrin levels are high in patients with pernicious anaemia but are likely to be low after total gastrectomy.Colonic pressure activity, however, especially after a protein-containing meal, is greater after total gastrectomy than in pernicious anaemia.3It would therefore seem unlikely that gastrin is involved in the colonic motor response to meals.3-Weare, etc.,
Symptomatic Crises of Sickle Cell Anemia Treated by Limited Exchange Transfusion
Authors: JEROME I. BRODY
Journal: Annals of Internal Medicine (1970)

Eight patients with the symptomatic crises of sickle cell anemia were treated by limited exchange transfusion. Buffy coat-free, packed erythrocytes were used in therapy. On the first day 250 ml red cells were given followed by phlebotomy of 500 ml whole blood and an infusion of a second 250 ml of red cells. The second day's program resembled the first except that two 250-ml units of red cells succeeded the phlebotomy. The method is not accompanied by untoward reactions, it rapidly ameliorates fever and bone pain; interrupts the cycle of hypoxia, vasocclusion, and organ injury by diluting autologous circulating erythrocytes containing sickle hemoglobin with those holding hemoglobin A; and raises the oxygen-carrying capacity of the blood with only a minor increase in total blood volume. The average length of hospital stay has been reduced from 7 to 3 days. This program probably should supplant other types of treatment that do not directly influence the dynamic changes involved in the pathogenesis of symptomatic crises in sickle cell anemia.
Seminars in Spine Surgery
Authors: Dawn Bick
Journal: JAMA (1992)

<i>Seminars in Spine Surgery</i>, edited by Sam W. Weisel from the Department of Orthopedic Surgery at George Washington University, offers reviews by noted authors on topics primarily involving the bony spine. Guest editors of both clinical and academic distinction have presented a variety of subjects, including cervical trauma, spinal stenosis, and neoplastic diseases of the spine. As of its third volume, the journal has devoted each issue to a single topic. The subscription fees are modest and feature a special low rate for students and residents. The purpose of<i>Seminars in Spine Surgery</i>is to address selected clinical topics that cover all parts of the spine, including basic anatomy and physiology, patho-physiology, and state-of-the-art methods of evaluation and treatment. For example, the inaugural issue focused on lumbar disk disease, discussing in considerable depth the pathogenesis, diagnosis, and methods of treatment, including surgical techniques and conservative approaches. Other issues deal with
Polycystic Kidneys and Renal Transplant Imaging
Authors: C J. Beadsmoore, H K. Cheow, J A. E. Dutton, A M. Peters
Journal: Clinical Nuclear Medicine (2005)

Renal transplantation is an ever-increasing procedure. Baseline DTPA renography is routinely performed in these patients in many centers to assess transplant perfusion and function. This report describes 2 cases of unusual appearance at renography resulting from the native polycystic kidneys.
Damage <i>v</i> ability to cope shapes need for disaster aid
Authors: Kelechi E Nnoaham
Journal: BMJ (2005)

The purpose of this case study was to quantify the changes in basic haematological indices and swimming performance after intermittent normobaric hypoxia exposure (IHE) in two Olympian swimmers. Two female swimmers, middle-distance (MD) age 18 years, and long-distance (LD) age 22 years, completed a 15-day continuous regimen of 60-min a day IHE. Following routine pool training in the morning, swimmers were exposed to hypoxia for 6 min by having them breathe through a simulated device that restricted delivery of O<sub>2</sub> to the body. This was followed by 4 min of normoxia breathing room air. Hypoxic conditions were replicated in a graded declination in percentage of O<sub>2</sub> saturation as recommended by manufacturer: 90% (for the first 2 days), 85% (second 2 days), 80% (third 2 days) and 75% (last 9 days). Before and after the IHE, blood samples were collected for the analysis of red cell count (RBC), haemoglobin concentration (Hb) and haematocrit (Hct) while a 16×100-m incremental swimming test (with the final 100 m in all-out effort) was conducted to track performance changes. There were no significant changes in RBC, Hb or Hct of either swimmer after IHE. Heart rate during the graded swim test was the same before and after IHE. Rating of perceived exertion during each stage was lowered in MD but unaltered in LD. Performance time of 100 m all-out effort showed 4.8% and 1.6% declines in MD and LD, respectively. IHE does not seem to bring about positive changes in haematological response and swimming performance of highly competitive female swimmers. This might be because the hypoxic dose of IHE in the present study did not reach the threshold stimulus for haematological and performance benefits.