Statin-Associated Myopathy with Normal Creatine Kinase Levels
Authors: Louis Evan Teichholz
Journal: Annals of Internal Medicine (2003)

Letters17 June 2003Statin-Associated Myopathy with Normal Creatine Kinase LevelsLouis Evan Teichholz, MDLouis Evan Teichholz, MDHackensack University Medical Center; Hackensack, NJ 07601 (Teichholz)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-12-200306170-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Phillips and colleagues (1) posited that myopathy with normal creatine kinase levels may occur in patients receiving statin therapy. Patients with muscular pain or weakness but without elevated enzyme levels pose an important clinical problem, although the exact incidence of this disorder is not known. Phillips and colleagues did not discuss a potential mechanism or mechanisms. However, they reported 3-methylglutaconic aciduria consistent with respiratory chain dysfunction and pathologic findings similar to those found in coenzyme Q10 deficiency (2). The American College of Cardiology/American Heart Association/National Heart, Lung, and Blood Institute clinical advisory states that ubiquinone (coenzyme Q10) ...References1. Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, . Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med. 2002;137:581-5. [PMID: 12353945] LinkGoogle Scholar2. Ogasahara S, Engel AG, Frens D, Mack D. Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy. Proc Natl Acad Sci U S A. 1989;86:2379-82. [PMID: 2928337] CrossrefMedlineGoogle Scholar3. Pasternak RC, Smith SC, Bairey-Merz CN, Grundy SM, Cleeman JI, Lenfant C, . ACC/AHA/NHLBI clinical advisory on the use and safety of statins. J Am Coll Cardiol. 2002;40:567-72. [PMID: 12142128] CrossrefMedlineGoogle Scholar4. Baker SK, Tarnopolsky MA. Statin myopathies: pathophysiologic and clinical perspectives. Clin Invest Med. 2001;24:258-72. [PMID: 11603510] MedlineGoogle Scholar5. Rosenfeldt FL, Pepe S, Ou R, Mariani JA, Rowland MA, Nagley P, . Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue. Biofactors. 1999;9:291-9. [PMID: 10416043] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Hackensack University Medical Center; Hackensack, NJ 07601 (Teichholz) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoStatin-Associated Myopathy with Normal Creatine Kinase Levels Paul S. Phillips , Richard H. Haas , Sergei Bannykh , Stephanie Hathaway , Nancy L. Gray , Bruce J. Kimura , Georgirene D. Vladutiu , John D.F. England , and Statin-Associated Myopathy with Normal Creatine Kinase Levels Paul S. Phillips and Richard H. Haas Statin-Associated Myopathy with Normal Creatine Kinase Levels Mark H. Hyman Statin-Associated Myopathy with Normal Creatine Kinase Levels Josh Torgovnick and Edward Arsura Statin-Associated Myopathy with Normal Creatine Kinase Levels Emil Toma and Maude Loignon Metrics Cited byEffects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolitesCurrent awareness: Pharmacoepidemiology and drug safety 17 June 2003Volume 138, Issue 12Page: 1008KeywordsCellsCoenzymesComplementary and alternative medicineCreatine kinaseEnzymesHeartLungsMolecular biologyMusclesStatins ePublished: 17 June 2003 Issue Published: 17 June 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...