Cyclosporine and Renal Prostaglandin E_2 Production
Authors: ROLF A. K. STAHL
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 September 1985Cyclosporine and Renal Prostaglandin E2 ProductionROLF A. K. STAHL, M.D., KANZ LOTHAR, M.D., SABINE KUDELKAROLF A. K. STAHL, M.D., KANZ LOTHAR, M.D., SABINE KUDELKAAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-474_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the March issue Drs. Duarte (1) and Cohen and Strom (2) discussed whether a reduced glomerular filtration rate, hyperkalemia, and vasculopathy noted in patients treated with cyclosporine might be due to an inhibition of renal prostaglandin synthesis. We recently obtained data indicating that cyclosporine treatment reduces renal prostaglandin E2 formation.We compared the glomerular filtration rate, serum potassium level, and urinary prostaglandin E2and thromboxane B2excretion from 11 patients treated with cyclosporine with those in 11 renal transplant recipients who received azathioprine. The daily prednisolone dosage in both groups was not significantly different. No patient received diuretics....References1. DUARTE R. Cyclosporine: renal effects and prostacyclin [Letter]. Ann Intern Med. 1985;102:420. LinkGoogle Scholar2. COHENSTROM DT. Cyclosporine: renal effects and prostacyclin [Letter]. Ann Intern Med. 1985;102:420. LinkGoogle Scholar3. BANTLENATHSUTHERLANDNAJARIANFERRIS JKDJT. Effects on cyclosporine on the renin-angiotensin-aldosterone system and potassium excretion in renal transplant recipients. Arch Intern Med. 1985;145:505-8. CrossrefMedlineGoogle Scholar4. WEBERLARSSONANGGARD PCE. Stimulation of renin release from rabbit renal cortex by arachidonic acid and prostaglandin endoperoxides. Circ Res. 1976;39:868-73. CrossrefMedlineGoogle Scholar5. HIGASHIHARASTOKESKOKKOCAMPBELLDUBOSE EJJWT. Cortical and papillary micropuncture examination of chloride transport in segments of the rat kidney during inhibition of prostaglandin production. J Clin Invest. 1979;64:1277-87. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROLF A. K. STAHL, M.D.; KANZ LOTHAR, M.D.; SABINE KUDELKAAffiliations: University of Freiburg 7800 Freiburg Federal Republic of Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCyclosporine-Induced Hypertension After TransplantationSequential effects of cyclosporine therapy on blood pressure, renal function and neurohormonesDe novo hypertension after liver transplantation.Prostanoids in paediatric kidney diseasesLong-term complications of cardiac transplantationRenal side-effects of cyclosporin A with special reference to autoimmune diseasesAn increase in the ratio of thromboxane A2 to prostacyclin in association with increased blood pressure in patients on cyclosporine ACyclosporin A inhibits prostaglandin E2 formation by rat mesangial cells in cultureSystemic Hypertension Associated with Cyclosporine: A ReviewCyclosporine A nephrotoxicity — the role of thromboxane A2Cyclosporine A enhances platelet aggregationSuppression of plasma renin activity by cyclosporine 1 September 1985Volume 103, Issue 3Page: 474-474KeywordsDiureticsExcretionGlomerular filtration ratePotassiumProstaglandinRenal transplantationThromboxane ePublished: 1 December 2008 Issue Published: 1 September 1985 PDF downloadLoading ...