tbuckley/cabot-search huggingface dataset:
Iron Deficiency and Pica
Authors: JORGE J. GONZALEZ
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 November 1982Iron Deficiency and PicaJORGE J. GONZALEZ, M.D.JORGE J. GONZALEZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-5-789_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to address some of the points raised by Crosby (1) about iron deficiency and pica in the case we reported (2).After a full diagnostic work-up to exclude continued blood loss, the patient was started on oral therapy that she continued until her readmission with hypokalemia. Despite the gradual improvement in her hematological values, she continued to crave clay. The answer to the question of whether clay ingestion causes or is a symptom of iron deficiency anemia remains controversial. It is difficult to ignore the work of Minnich and associates (3) who showed both in-vitro...References1. CROSBY W. Clay ingestion and iron deficiency anemia [Letter]. Ann Intern Med. 1982;97:456. LinkGoogle Scholar2. GONZALEZOWENSUNGAROWERKWENTZ JWPEP. Clay ingestion: a rare cause of hypokalemia. Ann Intern Med. 1982;97:65-6. LinkGoogle Scholar3. MINNICHOKCUOGLUTARCON VAY. Pica in Turkey: II. The incidence and association with anemia. Am J Clin Nutr. 1968;21:78-86. CrossrefMedlineGoogle Scholar4. LEMINGREEDMARTELO PDO. Magnesium carbonate pica: an unusual case of iron deficiency. Ann Intern Med. 1981;94:660. LinkGoogle Scholar5. COLTMAN C. Pagophagio and iron lack. JAMA. 1969;207:513-16. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JORGE J. GONZALEZ, M.D.Affiliations: University of North Carolina Wilmington, NC 28402 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1982Volume 97, Issue 5Page: 789-789KeywordsBloodHematology and oncologyIngestionIron deficiencyIron deficiency anemia ePublished: 1 December 2008 Issue Published: 1 November 1982 PDF downloadLoading ...
Diagnosis of Thyroid Disease
Authors: G. Dean Barth
Journal: JAMA (1962)

<h3>To the Editor:—</h3> We have noticed with interest your mention of the kinemometer in the Question and Answers section ofThe Journal(<i>JAMA</i><b>178</b>:784 [Nov. 18] 1961). Having been closely associated with the kinemometer for several years, we have performed literally thousands of heel reflex tests and would be interested in knowing if your information is based on firsthand experience with the instrument, or, if not, on what authority you base your answers. We respect your conservative answers inThe Journalbut suggest that if you would use the test objectively for any period of time you would begin to doubt the validity of clinical judgment in the diagnosis of thyroid disorders.
Role of endogenous nitric oxide in the control of exocrine and endocrine pancreatic secretion in humans.
Authors: J W Konturek, K Hengst, E Kulesza, A Gabryelewicz, S J Konturek, W Domschke
Journal: Gut (1997)

BACKGROUND: Nitric oxide (NO) is an unstable vasodilator formed by NO synthetase (NOS) from L-arginine (L-Arg) in various cells but its role in the control of pancreatic secretion in humans has not been examined. AIMS: This study was designed to determine the role of endogenous NO in the control of exocrine and endocrine pancreas using NOS inhibitor, NG-monomethyl-L-Arg (L-NMMA). METHODS: Pancreatic secretion was stimulated by intravenous infusion of secretin (80 pmol/kg/h) plus caerulein (50 pmol/kg/h) and duodenal content was aspirated by gastroduodenal tube. Two series of tests with secretagogue infusion were performed, one, with addition of graded doses of L-NMMA and, another, with addition of a constant dose of L-Arg alone followed by L-NMMA alone and finally by a combination of L-Arg and L-NMMA. RESULTS: Addition of L-NMMA in graded doses (2-8 mumol/kg/h) reduced dose dependently the secretin-caerulein stimulated pancreatic enzyme secretion without alterations in the volume flow and bicarbonate outputs. The addition of L-Arg to L-NMMA reversed the inhibitory action of L-NMMA on protein enzyme response to secretin-caerulein in these subjects. Secretin-caerulein infusion caused significant increase in plasma insulin and pancreatic polypeptide levels but without changes in plasma glucagon or somatostatin levels. L-NMMA alone resulted in a significant fall in plasma insulin and pancreatic polypeptide levels, while L-Arg added to pancreatic secretagogue infusion caused a significant increase of plasma insulin and pancreatic polypeptide levels above those attained with secretagogues alone. After the addition of L-Arg to L-NMMA, both plasma insulin and pancreatic polypeptide levels rose significantly above the levels observed with L-NMMA plus secretin-CCK stimulation. CONCLUSION: This study provides evidence that the suppression of NOS reduces pancreatic enzyme secretion and the plasma insulin and pancreatic polypeptide levels suggesting that endogenous NO affects both exocrine and endocrine pancreatic secretion in humans.
More on Sulfinpyrazone after Myocardial Infarction
Authors: William B. Hood
Journal: New England Journal of Medicine (1982)

This issue of the Journal carries another chapter in the saga of the Anturane Reinfarction Trial. This report1 presents the results of a special committee chaired by Dr. Bertram Pitt that was given the responsibility of reanalyzing in blinded fashion all the deaths that occurred in this trial to determine whether the results reported earlier2 , 3 could be reproduced.The steps leading up to this latest undertaking were summarized in an earlier Journal editorial,4 but it is worthwhile to retrace them here. In 1978 the Anturane Reinfarction Trial Study Group published a preliminary report on 1475 eligible patients with acute myocardial . . .
Low dose methotrexate osteopathy in a patient with polyarticular juvenile idiopathic arthritis
Authors: M Rudler, J Pouchot, F Paycha, S Gentelle, A Grasland, P Vinceneux
Journal: Annals of the Rheumatic Diseases (2003)

heumatoid vasculitis (RV) is a severe complication of rheumatoid arthritis (RA), which like a primary necrotising vasculitis can affect any organ but characteristically presents with painful cutaneous ulcers and systemic inflammation. 1 2Usually patients with refractory RA are affected who, therefore, had already undergone extensive immunosuppressive treatment.The prognosis is poor and most patients die from infectious complications, cardiac failure, or cerebral insult. [3]4][5][6] Cyclophosphamide (CYC) is the preferred treatment but is often not well tolerated and does not contain the synovitis. 3 We report the cases of three patients with RV who could not sufficiently be treated by CYC and steroids but responded very well to infliximab infusion therapy. CASE REPORTSCase 1 A 48 year old male patient with longlasting RA was admitted because of general malaise, dyspnoea, oedema, pleural and pericardial effusions, increased creatinine and liver enzymes, leucocytopenia, thrombocytopenia, decreased C4 and CH 50 , and increased levels of circulating immune complexes.The diagnosis of RV was established.The patient's condition did not sufficiently improve after treatment with steroid pulses, high dose CYC, or even plasmapheresis.He developed a life threatening heart failure caused by a "swinging heart" due to the pericardial effusion, which required immediate and repeated drainage (fig 1).As a last resort we decided to start www.annrheumdis.com
American Ideas on Venereal Disease Control
Authors: R. R. Willcox
Journal: BMJ (1946)

The main pillars of any venereal disease control programme are: (1) the seeking and controlling of nests of infection, (2) prophylaxis; (3) getting patients and their contacts under observation and treatment; and (4) ensuring that those patients remain under treatment until they are at any rate non infectious to others. If 100% success could be obtained on all of these four points, then venereal disease as a public menace would be conquered. In order that all concerned may co operate to this end, the aims and the methods of arriving at them must be made public, and hence education and propa ganda to a greater or lesser degree are also essential. Let us consider briefly how far we have progressed along the road in this country. So far as seeking out nests of in fection is concerned prostitution is theoretically illegal, but anyone who walks in the West End of London can see that it is far from suppressed. Furthermore, girls known to be in the  profession  are not subject by law to medical examination. Candidates for marriage are not compelled to have a premarital blood test, though most hospital clinics do one as a routine measure in the case of pregnant women. To ensure that potentially infected people receive treatment we rely on voluntary methods of persuasion, and our attempts at legislation on this are confined to Regulation 33B, which is a step in the right direction, though from the aspect of V.D. control it is but a short distance along the path. To ensure that patients remain under treatment, arrangements via almoners and other V.D. clinic workers are as good as can be devised; on the other hand, for the tracing of infected contacts we have to rely on the public spirit and social conscience of the infected patient and the perseverance of the clinic doctor. When viewed dispassionately, we obviously have not got very far, and, as things stand at present, probably can get little farther. Unfortunately the traditional British ideas of liberty and freedom also have to include the freedom to have venereal disease and to transmit it to others. This has obstructed any attempts to obtain broader legislation. As a result the efforts of education and propaganda suffer from the same inherited traditions, and tend to be colourless and inhibited as compared with places where legislation has been enforced. From the point of view of effect, one would have thought that countries pos sessing the legislation would actually require less propaganda to attain the ends required than those where voluntary effort has to be relied on. In any case, the U.S.A., which has the advantages of much legislation, finds it needs quite a consider able amount of propaganda to reinforce it, and by comparison our efforts here are puny.
Mutant Prolactin Receptor and Familial Hyperprolactinemia
Authors: Paul J. Newey, Caroline M. Gorvin, Stephen J. Cleland, Christian B. Willberg, Marcus Bridge, Mohammed Azharuddin, Russell S. Drummond, P. Anton van der Merwe, Paul Klenerman, Chas Bountra, Rajesh V. Thakker
Journal: New England Journal of Medicine (2013)

Hyperprolactinemia that is not associated with gestation or the puerperium is usually due to tumors in the anterior pituitary gland and occurs occasionally in hereditary multiple endocrine neoplasia syndromes. Here, we report data from three sisters with hyperprolactinemia, two of whom presented with oligomenorrhea and one with infertility. These symptoms were not associated with pituitary tumors or multiple endocrine neoplasia but were due to a heterozygous mutation in the prolactin receptor gene, PRLR, resulting in an amino acid change from histidine to arginine at codon 188 (His188Arg). This substitution disrupted the high-affinity ligand-binding interface of the prolactin receptor, resulting in a loss of downstream signaling by Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5). Thus, the familial hyperprolactinemia appears to be due to a germline, loss-of-function mutation in PRLR, resulting in prolactin insensitivity.
Freud and the "White Hotel".
Authors: D M Thomas
Journal: BMJ (1983)

I suppose that since Freud in my book talked about the original white hotel as the place where everyone has stayed I could say that I started to write the White Hotel in the womb, and I think the book does have all of my life experience there in some form or other. But I really began to write it about six years ago. I was reading the letters of Jung and Freud, both of them fascinat? ing people, and was particularly struck by the moment when their relationship, already under strain, broke off. There was a famous occasion in May 1912 when Freud travelled from Vienna to Lake Constance one weekend to visit a sick colleague, Binswanger, who had cancer; Jung, of course, was living just near Constance at Z?rich and he thought that as Freud had come such a long way it would not be far to come the extra few miles to see him for a few hours at Z?rich?while Freud thought that, as he was going all that way and he was much the older man, surely Jung could take the train journey on the branch line into Constance to see him for a few hours at Binswanger's clinic. As a result neither of them met, and it seemed to me, perhaps in my ignorance, a classic illustration of the tug between father and son: Jung was a sort of spiritual son of Freud and that marked symbolically the end of the relationship. I wrote a poem about it.
First-pass magnetic resonance imaging myocardial perfusion can determine microvascular dysfunction in acute myocardial infarction: Validation against angiographic thrombolysis in myocardial infarction frame count and myocardial blush score
Authors: Raymond Y. Kwong, Robert D. Winslow, Jennifer Blount, Minang Turakhia, Scott D. Solomon, E.Kent Yucel, Satyendra Giri
Journal: Journal of the American College of Cardiology (2003)
Occurrence of T‐cell lymphoma in a patient with philadelphia chromosome‐positive chronic myelogenous leukemia with rearrangements of BCR and TCR‐β genes in the lymph nodes
Authors: Pauline Tittley, Jean Marc Trempe, Richard van der Jagt, Jeanne Drouin, Lothar Huebsch, Bill McLeish, Gregory Cheng
Journal: American Journal of Hematology (1993)
β2-agonists in asthma
Authors: J.B.D Palmer, M.M Jenkins, Ronald Dahl, GrahamK Crompton, Julian Crane, Carl Burgess, Richard Beasley, Neil Pearce, T.J.H Clark, B.J Lipworth, D Newnham, D.G Mcdevitt, KevinM O'Shaughnessy, IanK Taylor, RichardW Fuller, O.P Twentyman, J.P Finnerty, Trevor Rogers, Katharine Higgins, Alyn Morice
Journal: The Lancet (1991)
CLINICAL SIGNIFICANCE OF HORMONE ASSAYS
Authors: S. CHARLES FREED
Journal: JAMA (1941)

Studies of the hormonal content of urine, blood and tissues are of significant value only when considered in relation to the clinical history, physical findings and other laboratory data of the patient. There are few tests which when considered apart from other evidence can be used safely for diagnostic purposes. In the past several years intensive investigations have pointed to the variability and complexity of tests performed for the purpose of diagnosing endocrine conditions. The results are complicated by the fact that the different laboratories vary in their technics and that there are factors of many sorts over which little control can be exercised and which interfere with the accumulation of uniform data. Definite progress has been made, however, by the use of biochemical procedures, in determining the quantities of certain hormonal substances. This advancement has been especially marked in assaying the numerous steroids of the ovary, testis and adrenal
Sphenoid Sinus Bleeding During Generalized Seizure
Authors: Lauro Wichert-Ana, Emerson Henklain Ferruzzi, Veriano Alexandre, Tonicarlo Rodrigues Velasco, Marino Muxfeldt Bianchin, Whemberton Martins Araújo, Antonio Carlos Santos, Paulo Mazzoncini de Azevedo-Marques, Lucas Ferrari de Oliveira, Marcus Vinícius Simões, Américo Ceiki Sakamoto
Journal: Clinical Nuclear Medicine (2006)

We report a 29-year-old male patient with right temporal lobe epilepsy who presented with a hot spot at the skull base on ictal SPECT suggesting a neuroglial tumor. The patient had chronic sinusitis and rare episodes of epistaxis. Tc-99m ECD was injected during a generalized seizure complicated by simultaneous nasal bleeding. Hematologic and laboratory tests and resting arterial blood pressure were normal. Computed tomography showed a blood clot in the left sphenoid sinus, and magnetic resonance imaging excluded sinusoidal pathology. Subtracted SPECT located a high concentration of the radiotracer within the left sphenoid sinus, the probable site of the nose bleeding.
P33 HEPATOPROTECTIVE EFFECT OF CeO2 NANOPARTICLES IN RATS TREATED WITH CCl4
Authors: D. Oró, G. Fernández-Varo, T. Yudina, E. Casals, G. Casals, B. González de la Presa, V.F. Puntes, W. Jiménez
Journal: Journal of Hepatology (2014)
A previously undescribed condition: tricho-odonto-onycho-dermal syndrome. A review of the tricho-odonto-onychial subgroup of ectodermal dysplasias
Authors: MARTA PINHEIRO, L.C. PEREIRA, N. FREIRE-MAIA
Journal: British Journal of Dermatology (1981)

SUMMARY An apparently hitherto undescribed ectodermal dysplasia/malformation syndrome is presented. The patient, the last son in an outbred sibship of four males, presents scalp hypotrichosis, aplasia cutis congenita of the scalp, dental abnormalities, onychodysplasia, dry skin with hypochromic and atrophic (poikiloderma-like) spots with vicarious (marginal) hyperchromia, unusual facies, asymmetrical skull, absent right nipple, irregular areolae, palmar keratosis, dermatoglyphic alterations, syndactyly, clinodactyly, phalangeal aplasias and hypoplasias, right leukoma, abnormal EEG, and other findings. The aetiology is unknown. A review of seventeen ectodermal dysplasias is presented for differential diagnosis.
Dynamics of 24-hour pulsatile cortisol, 17-hydroxyprogesterone, and androstenedione release in prepubertal patients with nonclassic 21-hydroxylase deficiency and normal prepubertal children
Authors: Lucia Ghizzoni, Sergio Bernasconi, Raffaele Virdis, Alessandra Vottero, Mariangela Ziveri, Cecilia Volta, Lorenzo Iughetti, Giorgio Giovannelli
Journal: Metabolism (1994)
CORONARY PLAQUE CHARACTERISTICS IN PATIENTS WITH DIABETES MELLITUS WHO PRESENTED WITH ACUTE CORONARY SYNDROME:OPTICAL COHERENCE TOMOGRAPHY STUDY
Authors: Jingbo Hou, Lei Xing, Haibo Jia, zhigang han, Shuang Yang, Lingbo Meng, Koji Kato, Tiashi Yonetsu, Soo Joong Kim, Hang Lee, Shaosong Zhang, Yu Bo, Ik-Kyung Jang
Journal: Journal of the American College of Cardiology (2012)
5′-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes†
Authors: Henar Hevia, Marta Varela-Rey, Fernando J. Corrales, Carmen Berasain, María L. Martínez-Chantar, Ujue M. Latasa, Shelly C. Lu, José M. Mato, Elena R. García-Trevijano, Matías A. Avila
Journal: Hepatology (2004)

5′-methylthioadenosine (MTA) is a nucleoside generated from S-adenosylmethionine (AdoMet) during polyamine synthesis. Recent evidence indicates that AdoMet modulates in vivo the production of inflammatory mediators. We have evaluated the anti-inflammatory properties of MTA in bacterial lipopolysaccharide (LPS) challenged mice, murine macrophage RAW 264.7 cells, and isolated rat hepatocytes treated with pro-inflammatory cytokines. MTA administration completely prevented LPS-induced lethality. The life-sparing effect of MTA was accompanied by the suppression of circulating tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS) expression, and by the stimulation of IL-10 synthesis. These responses to MTA were also observed in LPS-treated RAW 264.7 cells. MTA prevented the transcriptional activation of iNOS by pro-inflammatory cytokines in isolated hepatocytes, and the induction of cyclooxygenase 2 (COX2) in RAW 264.7 cells. MTA inhibited the activation of p38 mitogen-activated protein kinase (MAPK), c-jun phosphorylation, inhibitor kappa B alpha (IκBα) degradation, and nuclear factor κB (NFκB) activation, all of which are signaling pathways related to the generation of inflammatory mediators. These effects were independent of the metabolic conversion of MTA into AdoMet and the potential interaction of MTA with the cAMP signaling pathway, central to the anti-inflammatory actions of its structural analog adenosine. In conclusion, these observations demonstrate novel immunomodulatory properties for MTA that may be of value in the management of inflammatory diseases. (Hepatology 2004;39:1088-1098.)
The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas
Authors: Zuoxiang Xiao, Qun Jiang, Jami Willette-Brown, Sichuan Xi, Feng Zhu, Sandra Burkett, Timothy Back, Na-Young Song, Mahesh Datla, Zhonghe Sun, Romina Goldszmid, Fanching Lin, Travis Cohoon, Kristen Pike, Xiaolin Wu, David S. Schrump, Kwok-Kin Wong, Howard A. Young, Giorgio Trinchieri, Robert H. Wiltrout, Yinling Hu
Journal: Cancer Cell (2013)
Spinal Metastases of a High Grade Astrocytoma Visualized With FDG-PET
Authors: BURKHARD WOESLER, TORSTEN KUWERT, STEFAN PROBST-COUSIN, MICHAEL SCHÄFERS, HANDSDETLEF WASSMANN, FILIPPO GULLOTTA, OTMAR SCHOBER
Journal: Clinical Nuclear Medicine (1997)

A 42-year-old woman had experienced headaches, back pain, and progressive paraplegia 11 months after surgery and radiotherapy for an astrocytoma III-IV (World Health Organization) of the right frontal lobe. PET imaging with F-18-fluorodeoxyglucose showed multiple hypermetabolic lesions along the neuroaxis corresponding to contrast-enhancing tumors on spinal MRI, in particular at the level of the first and seventh cervical vertebra. Histopathologic examination of cerebrospinal fluid revealed atypical cells compatible with neoplasm. This combination of clinical, radiological, and histopathologic findings was interpreted as indicative of metastatic glioma along the spinal cord.
Influenza Pandemic Vaccines: Spread Them Thin?
Authors: Christophe Fraser
Journal: PLoS Medicine (2007)

The global spread of highly pathogenic H5N1 influenza through poultry flocks is driving a large research effort aimed at mitigating the worst effects of an eventual human pandemic. Mathematical models and computer simulations are being used to explore different policy options in influenza pandemic control (for examples, see [1–4]). In a new study published in PLoS Medicine, Riley, Wu, and Leung [5] use such exploratory modelling to tackle the thorny issue of what to do with limited stockpiles of pre-prepared influenza pandemic vaccines [5].
Renin and Rennin
Authors: James F. Burris
Journal: JAMA (1983)

<h3>To the Editor.—</h3> One often hears speakers discussing the renin-angiotensin-aldosterone system who pronounce the word<i>renin</i>as "wren-in." This is clearly an error. The correct pronunciation of<i>renin</i>is "ree-nin." The word<i>rennin</i>, which is correctly pronounced "wren-in," refers to an enzyme found in calves' stomachs that curdles milk and is used to make cheese. Rennin, which is also known as rennet or chymosin, has nothing whatever to do with hypertension. Renin is an enzyme produced in the kidney that is thought to play a role in the pathogenesis of at least some cases of hypertension. How important it is has been and remains a subject of much speculation in the hypertension research community, but it would seem appropriate for all at least to know how to pronounce properly a word that is so widely used.