tbuckley/cabot-search huggingface dataset:
Differential diagnosis of plantar wart from corn, callus and healed wart with the aid of dermoscopy
Authors: J.M. Bae, H. Kang, H.O. Kim, Y.M. Park
Journal: British Journal of Dermatology (2008)

Journal Article Differential diagnosis of plantar wart from corn, callus and healed wart with the aid of dermoscopy Get access J.M. Bae, J.M. Bae Department of Dermatology, Kangnam St. Mary's Hospital College of Medicine, The Catholic University of Korea, 505 Banpo‐Dong, Seochu‐Gu, Seoul 137‐040, Korea E‐mail: yymmpark@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar H. Kang, H. Kang Department of Dermatology, Kangnam St. Mary's Hospital College of Medicine, The Catholic University of Korea, 505 Banpo‐Dong, Seochu‐Gu, Seoul 137‐040, Korea E‐mail: yymmpark@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar H.O. Kim, H.O. Kim Department of Dermatology, Kangnam St. Mary's Hospital College of Medicine, The Catholic University of Korea, 505 Banpo‐Dong, Seochu‐Gu, Seoul 137‐040, Korea E‐mail: yymmpark@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar Y.M. Park Y.M. Park Department of Dermatology, Kangnam St. Mary's Hospital College of Medicine, The Catholic University of Korea, 505 Banpo‐Dong, Seochu‐Gu, Seoul 137‐040, Korea E‐mail: yymmpark@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 1, 1 January 2009, Pages 220–222, https://doi.org/10.1111/j.1365-2133.2008.08937.x Published: 01 January 2009
Harold Leslie Caplan
Authors: G. Fink
Journal: BMJ (2003)

Consultant in child and adolescent psychiatry St George's, University College, and Florence Nightingale Hospitals, London (b Melbourne, Australia, 1938; q Melbourne 1960; MPhil, FRACP, FRCPsych), died from malignant glioma on June 7 2003.​2003.




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Torn between medicine and literature, Harold Caplan read both with distinction, graduating MB BS in 1960 and BA with a major in English Literature in 1966. Psychiatry offered the perfect hybrid between medicine and literature. The most important of his several seminal contributions to psychiatry were his landmark prospective studies on the effect of maternal postnatal depression on the cognitive and emotional development of the child. He leaves his first wife, Betty (marriage dissolved in the 1980s); their two daughters; and his second wife, Wendel.
Development of novel small molecule MerTK and Flt3 tyrosine kinase inhibitors for treatment of acute leukemia
Authors: D. Graham, D. DeRyckere, K. Minson, C. Smith, A. Hill, M. Huey, E. Lasater, X. Wang, N. Shah, S. Frye, H. Shelton Earp
Journal: Annals of Oncology (2015)
An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis
Authors: H.M. Oosterkamp, H. Neering, S.M.B. Nijman, A.M.G. Dirac, W.J. Mooi, R. Bernards, T.R. Brummelkamp
Journal: British Journal of Dermatology (2006)

Journal Article An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis Get access H.M. Oosterkamp, H.M. Oosterkamp Division of Molecular Carcinogenesis and Center for Biomedical GeneticsDivision of Medical Oncology Search for other works by this author on: Oxford Academic Google Scholar H. Neering, H. Neering Division of Medical Oncology Search for other works by this author on: Oxford Academic Google Scholar S.M.B. Nijman, S.M.B. Nijman Division of Molecular Carcinogenesis and Center for Biomedical Genetics Search for other works by this author on: Oxford Academic Google Scholar A.M.G. Dirac, A.M.G. Dirac Division of Molecular Carcinogenesis and Center for Biomedical Genetics Search for other works by this author on: Oxford Academic Google Scholar W.J. Mooi, W.J. Mooi Division of Diagnostic Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar R. Bernards, R. Bernards Division of Molecular Carcinogenesis and Center for Biomedical Genetics R. Bernards. E‐mail: r.bernards@nki.nl Search for other works by this author on: Oxford Academic Google Scholar T.R. Brummelkamp T.R. Brummelkamp Division of Molecular Carcinogenesis and Center for Biomedical Genetics Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 1, 1 July 2006, Pages 182–185, https://doi.org/10.1111/j.1365-2133.2006.07224.x Published: 01 July 2006 Article history Accepted: 15 December 2005 Published: 01 July 2006
Perspectives on the Role of Viruses in Insulin-dependent Diabetes
Authors: Ji-Won Yoon, Usha R Ray
Journal: Diabetes Care (1985)

Insulin-dependent diabetes mellitus (IDDM) results from the destruction of pancreatic beta cells. Viruses have been suggested as one of the possible causes. The evidence for viruses comes largely from experiments in animals, but several studies in humans also point to viruses as a trigger of this disease in some cases. Encephalomyocarditis (EMC) virus, Mengovirus (2T), and Coxsackie B4 virus infect and destroy pancreatic beta cells when inoculated into mice. This results in hypoinsulinemia and hyperglycemia. The development of EMC virus–induced diabetes is dependent on the genetic background of the host and genetic makeup of the virus. Animals with diabetes for several months show some long-term complications, including glomerulosclerosis, ocular changes, and decreased bone formation and mineralization in addition to acute metabolic changes. EMC virus–induced diabetes can be prevented by a live-attenuated vaccine. The capacity of Coxsackie B4 virus to induce diabetes is also influenced by the genetic background of the host. However, Mengovirus-induced diabetes is not dependent on the genetic background of the host. In contrast to the EMC, Mengo, and Coxsackie B4 viruses, reovirus type 1 seems to be somehow associated with an autoimmune response producing a diabetes-like syndrome in suckling mice. This virus produces an autoimmune polyendocrinopathy that results in very mild and transient glucose intolerance. Several common human viruses including mumps, Coxsackie B3 and B4 viruses, and reovirus type 3 can infect human beta cells in culture and destroy them. A variant of Coxsackie B4 virus has been isolated from the pancreas of a child who died of acute-onset IDDM. Serologic studies revealed a rise in the titer of neutralizing antibody to the virus. This virus produced diabetes when inoculated into certain inbred strains of mice. Support for the idea that viruses can trigger some cases of diabetes in man has been strengthened lately by additional case reports and epidemiologic studies. However, it is evident that diabetes is not a common consequence of virus infection. In conclusion, based on the experiments in mice and studies in humans, it appears that at least an occasional case of IDDM may be triggered by a viral infection.
Reply to K. Lin et al
Authors: Luis Souhami, Kyounghwa Bae, Howard M. Sandler
Journal: Journal of Clinical Oncology (2009)

We thank Lin et al 1 for their interest and for their thoughtful comments on our article.They question the validity of our analysis, indicating a potential bias because of the exclusion of patients who discontinued hormonal therapy as a result of disease progression and death from causes other than prostate cancer.We agree with their point, and we did address the limitations of our hypothesis-generating analysis, including this issue, in our article. 2o overcome the specific limitation mentioned by Lin et al and to address the issue of bias, we performed a landmark analysis looking only at those patients who survived beyond 5 years in all three groups.The results of this analysis have been published in a previous correspondence to Journal of Clinical Oncology. 3Briefly, of the total of 189 patients who received less than 5 years of hormonal therapy in the original analysis, 145 (77%) were alive for at least 5 years.There were no significant changes in the distribution of pretreatment characteristics for the smaller, landmark subset of patients compared with the original 189-patient cohort.The 5-year landmark analysis continues to show a trend for an overall survival difference favoring more than 5 years hormonal duration (11-year survival, 64% v 50%), although this difference is no longer statistically significant (P ϭ .2),perhaps because of the smaller sample.There are, however, still statistically significant differences among the three hormonal therapy duration groups with respect to disease-free survival (P ϭ .0009),local failure (P ϭ .02),and distant metastases (P ϭ .002),favoring the longer hormonal therapy duration.The optimal duration of adjuvant hormonal therapy for patients with high-risk prostate cancer remains undetermined.As stated by Lin et al, 1 a recent randomized trial shows a detrimental effect on survival for a shorter course of hormonal therapy. 4Whether treatment duration beyond 5 years will be associated with a significant improvement in survival remains to be established, and only a properly designed randomized trial will unequivocally answer this provocative question.
Digital Hemodynamics in the Normotensive and Hypertensive States
Authors: FRANCIS S. CALIVA, RUDOLPH J. NAPODANO, ROBERT M. STAFFORD, WILLIAM LOFTUS, RICHARD H. LYONS
Journal: Circulation (1963)

Rheoplethysmographic studies were conducted to evaluate the digital hemodynamics of the hypertensive state. It is concluded that digital blood flow is similar in normal and hypertensive subjects; digital mean arterial pressures and calculated vascular resistances were significantly elevated in the hypertensive as compared to the normal subject; there is a small but definite increase in digital venous pressure in the hypertensive state; and the digital vasculature and in particular the arteriovenous shunts are otherwise similar in both the normal and the hypertensive subject.
An interesting case of complicated aortobifemoral graft: duodenal migration and colonic perforation
Authors: M. Ibis, I. Onal, C. Birincioglu, G. Nessar, M. Kurt, B. Celep, M. Ozkan, A. Tas, A. Sayilir, N. Sasmaz
Journal: Endoscopy (2009)

Here we present a case of complicated aortobifemoral graft. To the best of our knowledge it is the only case reported in the literature in which duodenal migration and colonic perforation were observed together and a colonoscopic view was obtained.
Effects of BAYm 1099, New α-Glucosidase Inhibitor, on Acute Metabolic Responses and Metabolic Control in NIDDM Over 1 Mo
Authors: Abu HB Samad, Thomas S Ty Willing, K George MM Alberti, Roy Taylor
Journal: Diabetes Care (1988)

To examine the clinical role of BAYm 1099, 15 diettreatednon-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/ day) or placebo after a 4-wk run-in period in a doubleblind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of each treatment period, three test meals (TMs) were administered: 60 g starch (TM1), 25 g sucrose (TM2), and combined 60 g starch and 25 g sucrose (TM3). Twelve subjects completed the study. The peak postprandial blood glucose, lactate, and pyruvate levels (means ± SE) were significantly lower with active drug after all test meals, particularly TM2 (11.3 ±1.0 vs. 14.3 ± 1.4 mM, P &amp;lt;.001; 1.53 ± 0.20 vs. 2.48 ± 0.17 mM, P &amp;lt; .001; and 105.1 ± 17.6 vs. 147.6 ± 11.1 μM, P &amp;lt; .05, respectively. Peak blood glucose levels were significantly delayed. However, fasting blood glucose, HbA1, fructosamine, and cholesterol did not change during active treatment (10.0 ±1.0 vs. 9.9 ±1.0 mM, 10.0 ± 0.7 vs. 9.4 ± 0.7%, 2.44 ± 0.10 vs. 2.37 ± 0.07 mmol/100 g protein, and 6.7 ± 0.3 vs. 6.5 ± 0.3 mM, P NS). Flatulence and diarrhea were severe in 2 subjects, requiring termination of study. Thus, in NIDDM, BAYm 1099 was effective in diminishing and delaying postprandial excursions of blood glucose, lactate, and pyruvate after high- and low-sucrose meals, but overall metabolic control remained unchanged. The results of acute studies on food absorption cannot be extrapolated to predict longer-term effects on glycemic control in diet-treated NIDDM subjects.
Metabolic activation routes of arylamines and their genotoxic effects.
Authors: J H Meerman, M L van de Poll
Journal: Environmental Health Perspectives (1994)

Two different types of DNA adducts are formed from many aromatic amines by bioactivation: N-acetylated and nonacetylated, arylamine DNA adducts. It has become clear from experiments using N-acetyl-2-aminofluorene and 2-aminofluorene adducts to C8 of deoxyguanosine that these two types of adducts may have different effects on DNA structure and DNA replication. We have determined blocking of DNA replication by various other N-acetylarylamine and arylamine deoxyguanosine adducts. It was found that the N-acetyl group in general is required for blocking of DNA replication; the nature of the aromatic moiety seems to be of minor importance. Little information is available on the genotoxic effects of these adducts in mammalian cells in vivo. We have tried to get more insight in this by investigating the clastogenicity, the initiation of preneoplastic cells, and the promotional effects of various aromatic amines from which different ratios of N-acetylarylamine DNA adducts to arylamine DNA adducts are formed in the rat liver. Our results show that formation of N-acetylarylamine adducts to C8 of deoxyguanosine in the liver is correlated with clastogenicity and hepatic promoting effect. Initiation capacities, however, seem to be correlated with formation of nonacetylated, arylamine adducts. Mechanisms by which formation of N-acetylarylamine DNA adducts may generate a promoting effect in the liver are discussed.
Homozygous variegate porphyria: a compound heterozygote with novel mutations in the protoporphyrinogen oxidase gene
Authors: R.A. Palmer, G.H. Elder, D_f. Barrett, S.G. Keohane
Journal: British Journal of Dermatology (2001)

Homozygous variegate porphyria results from mutations in both alleles of the protoporphyrinogen oxidase (PPOX) gene. Our patient, a 36‐year‐old woman, has severe cutaneous manifestations. Her clinical and biochemical features are similar to the few other reported cases, including onset before 18 months of age, photosensitivity, absence of acute porphyric attacks, and elevated erythrocyte protoporphyrin. Mutation analysis of the PPOX gene revealed an in‐frame 12 bp insert (c. 657–658 ins AAGGCCAGCGCC) encoding lysine–alanine–serine–alanine (KASA), and a G to A transition at the splice donor site of exon 11 (IVS 11–1 G→A). Neither of these mutations has been reported previously. Our patient's mother has the splice site mutation and has had acute porphyric episodes. A maternal first cousin has the same mutation but no clinical manifestations. The medical and family history of our patient's father is uncertain.
A multiple screening clinic.
Authors: R. J. Donaldson, J. M. Howell
Journal: BMJ (1965)

Acheson et al. (1963) have suggested criteria for selection of diseases suitable for presymptomatic diagnosis.The tests used must be simple, quick, reliable, and readily acceptable, and the condition subsequently discovered should prove amenable to treatment.In many areas screening tests for single diseases or groups of diseases are now widely applied: such techniques as mass radiography in adults, tests for phenylketonuria in infants, and pure-tone audiometry in schoolchildren have gained general acceptance.A few authorities have successfully conducted examinations of large populations for other conditions, such as diabetes.When two screening tests were offered together (Donaldson and Connolly, 1963) the public response was greater than could have been expected for either test alone.It was therefore decided to offer a battery of five tests, to detect chest diseases, diabetes, anaemia, deafness, and cervical carcinoma.Rotherham is a compact town with a population of 86,510, the main industry being steel production.A suite of rooms in the centrally situated town hall was used.Publicity, mainly directed at young and middle-aged adults, was confined to the two weeks immediately preceding the clinic, which was open for six consecutive days in the afternoon and evening.Only the age groups considered to be mainly at risk were encouraged to take the individual tests.These were listed as follows: anaemia, all ages ; diabetes, all ages ; chest x-ray, over 15 ; hearing, 15 to 60 ; cervical cancer, parous women aged 30-60.Quite clearly, it would be a waste of effort if conditions discovered were already known to the family doctor.
The medical profession, the public, and the government
Authors: C. Ham
Journal: BMJ (2002)

eased through honest discussion of the match between doctors' expectations and organisational and societal needs.It is also worth remembering that many doctors are happy and it will be important to ensure that they are fully engaged in helping to develop solutions.More discussion and research are required to understand this problem and its possible solutions in more detail.In the meantime there is a key role for leaders in the medical profession nationally and in hospitals and primary care to work together with NHS managers to develop a new compact that improves care for patients, improves the effectiveness of the healthcare organisation, and helps create a happier workforce.
The developmental toxicity of boric acid in mice, rats, and rabbits.
Authors: J J Heindel, C J Price, B A Schwetz
Journal: Environmental Health Perspectives (1994)

Boric acid (BA) is a naturally occurring agent used in manufacturing processes and numerous consumer products. Because of the potential for both industrial and consumer exposure to boron-containing compounds, and the lack of developmental toxicity data, the National Toxicology Program evaluated the potential for boric acid to cause developmental toxicity in pregnant Swiss (CD-1) mice, Sprague-Dawley rats (n = 26-28/group), and New Zealand rabbits (n = 18-23/group). BA was provided in the feed to mice and rats at 0, 0.1, 0.2, or 0.4% throughout gestation to attain steady-state exposure as early as possible during development. Average doses (mg/kg/day) were 248, 452, or 1003 for mice, and 78, 163, or 330 in rats. A separate group of rats received 0.8% BA in the feed, or 539 mg/kg/day only on gestation days (gd) 6 to 15. Rabbits were given BA (0, 62.5, 125, or 250 mg/kg) by gavage administration on gd 6 to 19. Maternal body weight, food and/or water consumption and signs of toxicity were monitored at regular intervals. At termination, gd 17 (mice), 20 (rats), or 30 (rabbits), the uterus was examined to determine the number of resorptions, dead, or live fetuses. Fetuses were weighed and live fetuses were examined for external, visceral, and skeletal defects. Mouse dams exhibited mild renal lesions (> or = 248 mg/kg/day BA), increased water intake and relative kidney weight (1003 mg/kg/day BA), and decreased weight gain during treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
Authors: Zhenhua Wu, Huang Guo, Nienwen Chow, Jan Sallstrom, Robert D Bell, Rashid Deane, Andrew I Brooks, Suhasini Kanagala, Anna Rubio, Abhay Sagare, Dong Liu, Fang Li, Don Armstrong, Thomas Gasiewicz, Raphael Zidovetzki, Xiaomei Song, Florence Hofman, Berislav V Zlokovic
Journal: Nature Medicine (2005)
Antibodies against p53 protein in serum of patients with benign or malignant pancreatic and biliary diseases.
Authors: P Laurent-Puig, R Lubin, S Semhoun-Ducloux, G Pelletier, C Fourre, M Ducreux, M J Briantais, C Buffet, T Soussi
Journal: Gut (1995)

Specific markers for pancreatic or biliary cancer have been developed in the past few years. Ca 19-9 has a good sensitivity but it is also increased in benign cholestasis. Mutations in the p53 gene are commonly reported in pancreatic cancer and can be detected by a serological analysis. The aim of this work was to find out the sensitivity and specificity of this new assay in diagnosing cancer of the pancreas or of the bile ducts. The presence of antibodies against p53 was determined by an enzyme linked immunosorbent assay (ELISA) in 29 patients with pancreatic cancer, 33 with biliary tract cancer, and 33 with benign biliary or pancreatic diseases as controls. p53 Antibodies were detected in eight of 29 patients with pancreatic cancer (28%), in five of 33 patients with biliary tract (15%), and in one patient (3%) with stones of the common bile duct. The sensitivity and the specificity for the diagnosis of malignant biliary or pancreatic diseases were 21% and 96% respectively. It is concluded that the presence of p53 antibodies in the serum of patients with pancreatic and biliary diseases is specific for malignancy and independent from the presence of cholestatic disease.
Tenofovir Disoproxil Fumarate versus Adefovir Dipivoxil for Chronic Hepatitis B
Authors: Patrick Marcellin, E. Jenny Heathcote, Maria Buti, Ed Gane, Robert A. de Man, Zahary Krastev, George Germanidis, Sam S. Lee, Robert Flisiak, Kelly Kaita, Michael Manns, Iskren Kotzev, Konstantin Tchernev, Peter Buggisch, Frank Weilert, Oya Ovung Kurdas, Mitchell L. Shiffman, Huy Trinh, Mary Kay Washington, Jeff Sorbel, Jane Anderson, Andrea Snow-Lampart, Elsa Mondou, Joe Quinn, Franck Rousseau
Journal: New England Journal of Medicine (2008)

Tenofovir disoproxil fumarate (DF) is a nucleotide analogue and a potent inhibitor of human immunodeficiency virus type 1 reverse transcriptase and hepatitis B virus (HBV) polymerase.
NICE guidance on laparoscopic surgery for inguinal hernias: Late adapters may never change
Authors: G. Waldron
Journal: BMJ (2003)

EDITOR—With respect to the impact of NICE guidance on laparoscopic surgery for inguinal hernias by Bloor et al,1 any change process, regardless of the quality of evidence backing it up, is enthusiastically embraced by only a minority of up to 20%, the “early …
Antibiotics in Milk
Authors: G. J. Wilkins
Journal: BMJ (1963)

impression that the veterinary surgeon is entirely to blame for the unsatisfactorily large amounts of antibiotics in milk leaving dairy farms, may I be permitted to add a small rider ?The veterinary surgeon all too often arrives in the cowshed to find that intramammary antibiotics have already been obtained by the farmer, and may have already been used.Furthermore, the practitioner may not be informed of such treatment.The veterinary profession is seriously concerned about the dangers of such circumstances, and the Veterinary Record of the same date as your own article devotes four pages to the subject.The law provides for supervision of distribution of antibiotics to farmers, but in the farmer's and everybody's interests more effective control must be implemented.-Iam, etc.,