tbuckley/cabot-search huggingface dataset:
Abstract LB-7: Epigenetic silencing of IRF8 expression is associated with myeloid leukemia escape from cancer immunosurveillance
Authors: Xiaolin Hu, Kebin Liu
Journal: Cancer Research (2010)

Abstract Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease (MPD) that comprises 15-20% of human hemapoietic cancers. Exciting advances in molecular mechanism-based strategies have yielded imatinib mesylate/STI571/Gleevec, which has proven to be effective in many human patients with CML. Unfortunately, Gleevec is not effective in some human CML patients, whereas some CML patients become refractory to Gleevec due to the development of drug resistance caused by mutations in abl. Furthermore, Gleevec becomes significantly less effective if the CML evolves to blast crisis. Therefore, elucidating the molecular mechanisms underlying CML pathogenesis is of significance for the development of more effective molecular target-based therapy for CML patients. In this study, we demonstrated that the IRF8 expressed is decreased in human CML/AML cells and the IRF8 promoter is methylated in human CML/AML cells and in PMBC derived from human CML patients. Ectopic expression of IRF8 in myeloid cells suppressed tumor development in mice in vivo. We further demonstrated that IRF8 regulates Fas and FLIP expression in myeloid leukemia cells to mediated Fas-mediated apoptosis. Taken together, our data suggest that myeloid leukemia cells use DNA methylation to silence IRF8 expression to acquire a Fas-resistant phenotype to escape from cancer immunosurveillance. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-7.
An Easy Operation for Congenital Ptosis
Authors: F. Fergus
Journal: BMJ (1901)

OPERATION.FOR CONGENITAL PTOSIS.IMMcin 30, 191. in ten days only slight trace present, less than i &r. to ounce.Case iv.- Sugar IS grs. to ounce; diet kept unchanged ; after six weeks of sodium salicylate treatment sugar only 3 grs.to the ounce; in 20 days later no reaction for sugar by usual methods of testing, but by special methods .theslightest trace detected.Case v.-Sugar, 30 grs. to ounce; in sixteen days 6t grs. to ounce.Case vI.-Specific gravity I033; sugar, considerable amnount; in three weeks a trace only; a month later sugar absent.-Case vII.-Sugar excretion had been arrested by restricted diet; a few weeks later sugar returned (24 grs. to the ounce); diet kept the same, and sodiuin salicylate given; in two weeks oiily sliglhtest trace of sugar present: shortly afterwards it disappeared; six months later sugar again appeared in the urine, but disappeared when sodium salicylate was given.Case vIII.-Sugar, 2 grs. to the ounce; reduced to slightest trace (not detected by Fehlhng's solution) under sodium salicylate.I am prepared to admit that in the Cases I to vIII tlle results were not quite conclusive, since
Superoxide dismutase and N-2-mercaptopropionyl glycine attenuate infarct size limitation effect of ischaemic preconditioning in the rabbit
Authors: M. Tanaka, H. Fujiwara, K. Yamasaki, S. Sasayama
Journal: Cardiovascular Research (1994)

Objective: Ischaemic preconditioning may be mediated by oxygen free radicals generated during preconditioning. Conflicting results have been reported regarding the effect of superoxide dismutase (SOD) in attenuating the cardioprotective effect of preconditioning. The aim of the study was to reconcile this conflict by examining the effect of three different oxyradical scavengers on the infarct size limiting effect of preconditioning, Methods: Anaesthetised open chest rabbits were subjected to 30 min coronary occlusion and 48 h reperfusion. In the preconditioning groups, rabbits were subjected to a single 5 min occlusion and 5 min reperfusion before 30 min sustained ischaemia. In these groups, the oxyradical scavengers SOD (15 000 U·kg−1), N-2-mercaptopropionyl glycine (MPG, 20 mg·kg−1), and dimethylthiourea (DMTU, 500 mg·kg−1), or placebo saline, were infused before and during preconditioning, in the non-preconditioning groups, these agents were given in the same time frame before 30 min of ischaemia. After 2 d reperfusion, infarct size was measured microscopically. Results: In the saline treated controls, preconditioning markedly limited microscopical infarct size (percent of area at risk): 13(SEM 3)% (n = 9) v 49(9)% (n = 8), p < 0.05. Treatment of the preconditioning groups with SOD or MPG attenuated this cardioprotection [infarct size 31(5)% (n = 11) and 42(8)% (n = 11), respectively, p < 0.05 v the saline treated preconditioning group], but treatment with DMTU did not [infarct size 23(6)% (n = 11), p = NS v the saline treated preconditioning group]. In the non-preconditioning groups, none of the treatments modified infarct size: 50(9)% (n = 7), 56(5)% (n = 8), and 61(6)%, (n = 8), respectively, p = NS v saline treated control. Conclusions: Cardioprotection by preconditioning is mediated, at least in part, by oxyradicals which are scavenged by SOD or MPG in rabbits. Cardiovascular Research 1994;28:980-986
Idiopathic chronic eosinophilic pneumonia associated with noncaseating epithelioid granulomas
Authors: N Shijubo, T Fujishima, S Morita, H Nakata, M Satoh, E Uno, T Morikawa, S Abe
Journal: European Respiratory Journal (1995)

A 34 year old Japanese woman was referred to our university hospital due to pulmonary opacities and bilateral hilar lymphadenopathy on chest X-ray. She also had uveitis, erythematous skin nodules, and oral and genital ulcers. Laboratory data showed eosinophilia in the circulation and bronchoalveolar lavage fluid. Histological study revealed massive eosinophilic infiltration and noncaseating epithelioid granulomas in the lung and mediastinal lymph node, without evidence of vasculitis. Pulmonary opacities, lymphadenopathy, and blood eosinophilia promptly improved with corticosteroid therapy. In this patient, idiopathic chronic eosinophilic pneumonia overlapped with features of sarcoidosis and Behcet's disease.
Therapeutic Angiogenesis With Intramuscular NV1FGF Improves Amputation-free Survival in Patients With Critical Limb Ischemia
Authors: Sigrid Nikol, Iris Baumgartner, Eric Van Belle, Curt Diehm, Adriana Visoná, Maurizio C Capogrossi, Nicole Ferreira-Maldent, Augusto Gallino, Michael Graham Wyatt, Lasantha Dinesh Wijesinghe, Melissa Fusari, Dominique Stephan, Joseph Emmerich, Giulio Pompilio, Frank Vermassen, Emmanuel Pham, Vincent Grek, Michael Coleman, François Meyer
Journal: Molecular Therapy (2008)

This study evaluated the efficacy and safety of intramuscular administration of NV1FGF, a plasmid-based angiogenic gene delivery system for local expression of fibroblast growth factor 1 (FGF-1), versus placebo, in patients with critical limb ischemia (CLI). In a double-blind, randomized, placebo-controlled, European, multinational study, 125 patients in whom revascularization was not considered to be a suitable option, presenting with nonhealing ulcer(s), were randomized to receive eight intramuscular injections of placebo or 2.5 ml of NV1FGF at 0.2 mg/ml on days 1, 15, 30, and 45 (total 16 mg: 4 × 4 mg). The primary end point was occurrence of complete healing of at least one ulcer in the treated limb at week 25. Secondary end points included ankle brachial index (ABI), amputation, and death. There were 107 patients eligible for evaluation. Improvements in ulcer healing were similar for use of NV1FGF (19.6%) and placebo (14.3%; P = 0.514). However, the use of NV1FGF significantly reduced (by twofold) the risk of all amputations [hazard ratio (HR) 0.498; P = 0.015] and major amputations (HR 0.371; P = 0.015). Furthermore, there was a trend for reduced risk of death with the use of NV1FGF (HR 0.460; P = 0.105). The adverse event incidence was high, and similar between the groups. In patients with CLI, plasmid-based NV1FGF gene transfer was well tolerated, and resulted in a significantly reduced risk of major amputation when compared with placebo.
CDC Targets Health-Related Infections Acquired in Outpatient Settings
Authors: Bridget M. Kuehn
Journal: JAMA (2011)

IN 2008, MORE THAN 40 000 INDIVIDUals treatedatanoutpatientendoscopy clinic in Nevada were advised to undergo testing for hepatitis B and C infection after state and federal public health officials discovered improper use of syringesand theuseof single-dosevialson multiplepatients.Ultimately,6confirmed cases were identified among patients of the clinic. Unfortunately, scientists from the US Centers forDiseaseControl andPrevention (CDC) have found that such lapses inbasic infectioncontrolpracticesare far toocommoninoutpatientsettings.Infact, between1998and2008,33outbreaks in which 448 individuals acquired hepatitis B or C infection were linked to outpatient care (Thompson ND et al. Ann Intern Med. 2009;150[1]:33-39). To help curb such health care– associated infections, the CDC has created a guideline (http://tinyurl.com /3cdl3sl) and checklist (http://tinyurl .com/3r497zy) that clinicians working inoutpatient settingscanuse tohelpensure that appropriate infection control practicesarebeing followed.Theagency is alsoworkingwithotherorganizations to boost awareness about this problem and enhance oversight of outpatient facilities to prevent lapses.
Crohn's Disease Is a Risk Factor for Preterm Birth
Authors: Olof Stephansson, Heidi Larsson, Lars Pedersen, Helle Kieler, Fredrik Granath, Jonas F. Ludvigsson, Henrik Falconer, Anders Ekbom, Henrik Toft Sørensen, Mette Nørgaard
Journal: Clinical Gastroenterology and Hepatology (2010)
Immunisation and counselling for Kosovar refugee children
Authors: J. Ciment
Journal: BMJ (1999)

In an effort to cope with the medical and psychological needs of children among the Kosovar refugees, Unicef has embarked on several immunisation and counselling programmes in Albania, Macedonia, and Montenegro.

Last week, the agency began immunising around 9000 children under the age of 5 who had fled to refugee camps in Macedonia. The vaccinations included in the programme are against routine childhood diseases, including polio, diphtheria, measles, rubella, whooping …
EARACHE OF OBSCURE ORIGIN
Authors: W. Wilson
Journal: BMJ (1914)

tlle enlargement.In a condition suclh as tolnsillar elnlarge inent, a patient is justifiedI in expecting a cure after operation.In adults eitlher complete or partial removal is a much mlore severe operation than in children, and the risk of lhaem-orrhage is greater in both cases, though possibly greater when the tonsil is enueleated.As the operation
Researchers discover how opiates cause immunosuppression
Authors: A. Berger
Journal: BMJ (1999)

Opiate drugs are potent painkillers and are also used recreationally. Opiates are known to suppress the immune system, and immunologists at the Jerome H Holland Laboratory for Biomedical Sciences at the American Red Cross in Maryland have discovered how this immune suppression comes about (Nature 1999;397:218).

Yufang Shi and colleagues have been studying the role of programmed cell death (apoptosis) in the regulation of the immune system. One mechanism known to trigger apoptosis in lymphocytes involves a protein receptor called …
Quantitative and qualitative changes in the early insulin response to glucose in subjects with impaired carbohydrate tolerance
Authors: Klaus Peter Ratzmann, Bernd Schulz, Peter Heinke, Dietrich Michaelis
Journal: Diabetes Care (1981)

To investigate changes in the sensitivity of early insulin repsonse to glucose, a pulse stimulation of 1.0, 2.5, and 5.0 g glucose was carried out at intervals of 30 min in 73 nonobese subjects suspected of having an impaired carbohydrate tolerance (CHT) and 24 body-weight and sex-matched healthy controls without a family history of diabetes. CHT was characterized by means of a 2-h glucose infusion test (GIT; 12 mg/kg-min), primed by an initial injection of 0.33 g/kg. Subjects suspected of having an impaired CHT (glucosuria in all subjects, 49 of whom exibited a borderline or pathologic 50-g standard oral glucose tolerance test and 27 of whom had a family history of diabetes) were classified as having a normal, borderline, and pathologic CHT according to the result of GIT. Compared with controls the early insulin response (∆IRI area, 0–5 min) during GIT was significantly reduced in subjects with normal, borderline, and pathologic CHT. During staircase glucose stimulation, a dose-dependent significant increase of the ∆max IRI response was observed in controls, whereas this strong relationship was lacking in all other groups studied. In subjects with normal, borderline, and pathologic CHT, ∆max IRI responses revealed by pulse stimulation of 1.0, 2.5, and 5.0 g glucose were significantly reduced compared with controls. Besides quantitative differences in early insulin response among all groups studied, a shift of the glucoseinsulin dose-response curve to the right was found in subjects with normal, borderline, and pathologic CHT. Our results provide further evidence of a reduced sensitivity of the pancreatic beta-cells to glucose during development of carbohydrate intolerance. The staircase glucose stimulation enables both a quantitative evaluation of the early insulin response to glucose and a characterization of the glucose-insulin dose-response relationship. For this reason the test seems to be a useful tool in studying the sensitivity of the pancreatic beta-cells to glucose.
Circulating leptin and adiponectin levels in patients with primary hyperparathyroidism
Authors: Enrica Delfini, Luigi Petramala, Chiara Caliumi, Darlo Cotesta, Giorgio De Toma, Giuseppe Cavallaro, Giuseppe Panzironi, Daniele Diacinti, Savatore Minisola, Emilio D' Erasmo, Gian Franco Mazzuoli, Claudio Letizia
Journal: Metabolism (2006)
Hegemony in Medicine Revisited
Authors: Neil L. Chayet
Journal: New England Journal of Medicine (1976)

The editorial written by the editor of the New England Journal of Medicine that appeared in the issue of October 16, 1975, entitled "Legal Hegemony in Medicine," is deeply troubling. The article chastised physicians for seeking redress in courts of law, and bemoaned actions that "enhanced the powers of the lawyer and undermined those of the petitioning physician," and thus drives deeper the wedge dividing the professions.At face value, Dr. Ingelfinger's words may be welcomed by physicians who embrace the concept made immortal by Shakespeare that all would be well again if only all the lawyers could be disposed . . .
Metastin Inhibits Migration and Invasion of Renal Cell Carcinoma with Overexpression of Metastin Receptor
Authors: Sunao Shoji, Xian Yan Tang, Shinobu Umemura, Johbu Itoh, Susumu Takekoshi, Masanori Shima, Yukio Usui, Yoshihiro Nagata, Toyoaki Uchida, Robert Yoshiyuki Osamura, Toshiro Terachi
Journal: European Urology (2008)
A SERIES OF INTERESTING CASES OF SURGICAL CONDITIONS OF THE KIDNEY.
Authors: G. FRANK LYDSTON
Journal: JAMA (1906)

<h3>CASE I.—RENAL SARCOMA IN A CHILD.</h3><h3>History.</h3> —A child, a year and a half old, was brought to me with a history of hematuria of four weeks' standing, and with a "lump" in the right side. The tumor had been discovered accidentally only a few weeks before the hematuria began; it was, therefore, impossible to determine when the growth had first developed. The child had always been fretful and poorly nourished, but had apparently suffered no pain until five or six weeks before I was consulted. There was a history of possible injury to the back some six months before the hematuria was noticed. A blow on the back was produced by the nurse letting the child fall in taking it out of the crib. The child cried a little after the accident, but was soon thereafter apparently none the worse for it. Family history was negative. <h3>Examination.</h3> —Examination revealed
Osteoprotegerin Overexpression by Breast Cancer Cells Enhances Orthotopic and Osseous Tumor Growth and Contrasts with That Delivered Therapeutically
Authors: Jane L. Fisher, Rachel J. Thomas-Mudge, Jan Elliott, Daphne K. Hards, Natalie A. Sims, John Slavin, T. John Martin, Matthew T. Gillespie
Journal: Cancer Research (2006)

Osteoprotegerin (OPG) acts as a decoy receptor for receptor activator of NF-kappaB ligand (RANKL), which is a pivotal molecule required for osteoclast formation. In vitro OPG inhibits osteoclast formation and in vivo (administered as Fc-OPG) it reduces hypercalcemia and the establishment of osteolytic lesions in mouse models of tumor cell growth in bone. Osteolysis can be induced by parathyroid hormone-related protein (PTHrP) produced by breast cancer cells that results in an increased osteoblastic RANKL/OPG ratio. We examined the effect of local tumor production of OPG on the ability of breast cancer cells to establish and grow in bone and mammary fat pad. MCF-7 cells or MCF-7 cells overexpressing PTHrP were transfected with full-length OPG and inoculated into the proximal tibiae of athymic nude mice. Mice injected with cells overexpressing PTHrP and OPG showed enhanced tumor growth, increased osteolysis (2-fold compared with MCF-7 cells overexpressing PTHrP), and altered histology that was reflective of a less differentiated (more aggressive) phenotype compared with MCF-7 cells. In contrast, administration of recombinant Fc-OPG reduced tumor growth and limited osteolysis even in mice inoculated with OPG overexpressing cells. Similarly, OPG overexpression by breast cancer cells enhanced tumor growth following orthotopic inoculation. These results indicate that OPG overexpression by breast cancer cells increases tumor growth in vivo and that there are strikingly different responses between therapeutically administered Fc-OPG and full-length OPG produced by tumor cells.
Jerico Springs, Missouri
Authors: Brent Swager
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevention of ventilator-associated pneumonia: possible role of antimicrobials administered via the respiratory tract
Authors: M. E. Falagas, I. I. Siempos
Journal: European Respiratory Journal (2008)

severe hypoxaemia under hypoxic conditions?Limited data from the literature suggest that patients with very severe obstructive lung disease (forced expiratory volume in one second of ,1 L [6] and/or hypercapnia [7,8]) are at risk of severe in-flight hypoxaemia despite a good ground-level Sp,O 2 .Accordingly, it would also be interesting to have answers to the following questions concerning Global Initiative for Chronic Obstructive Lung Disease stage IV chronic obstructive pulmonary disease patients.1) How many patients with a ground-level arterial oxygen saturation measured by pulse oximetry of .95%underwent hypoxic challenge testing?2) How many patients flew without oxygen and without preflight hypoxic challenge testing?
DABIGATRAN ETEXILATE VERSUS WARFARIN IN PATIENTS WITH DIFFERENT TYPES OF ATRIAL FIBRILLATION: A RE-LY® SUBGROUP ANALYSIS
Authors: Greg C. Flaker, Paul Reilly, Salim Yusuf, Mike Ezekowitz, Lars Wallentin, Martina Brueckmann, Stuart Connolly
Journal: Journal of the American College of Cardiology (2011)
Biperiden in the Treatment of Phenothiazine-Induced Extrapyramidal Reactions
Authors: Carlos Medina, Morton D. Kramer, Albert A. Kurland
Journal: JAMA (1962)

THE EXTENSIVE USE of phenothiazine drugs in the treatment of emotional disorders and their usefulness in such areas as anesthesiology, obstetrics, geriatrics, and neurology make a knowledge of their side effects, and the treatment of these, important. The most common side effects are of a neurological nature, namely, extrapyramidal effects. An incidence of almost 40% of such drug-induced reactions was reported in a series of several thousand patients being treated with phenothiazines for emotional disturbances. Some of the factors which may play a role relative to this sensitivity are gradually being outlined. Numerous clinical investigations have demonstrated that the drug-induced extrapyramidal-like syndromes are only different from those clinically seen following naturally occurring diseases, such as paralysis agitans ( parkinsonism ) and postencephalitic varieties of basal ganglia disturbances, in that the drug-induced reactions are generally considerd reversible and respond readily to treatment with antiparkinsonian drugs. The recognition and the careful evaluation
PROGRESSION OF ATRIAL FIBRILLATION AFTER TRANSCATHETER CLOSURE OF ATRIAL SEPTAL DEFECTS: SUCCESSFUL TREATMENT WITH RADIOFREQUENCY CATHETER ABLATION
Authors: Pasquale Santangeli, Luigi Di Biase, J. David Burkhardt, Rodney Horton, Javier Sanchez, Shane Bailey, Jason Zagrodzky, Dhanunjaya Lakkireddy, Rong Bai, Prasant Mohanty, Sanghamitra Mohanty, Salwa Beheiry, Richard Hongo, Andrea Natale
Journal: Journal of the American College of Cardiology (2012)
Sildenafil Improves Coronary Artery Patency in a Canine Model of Platelet-Mediated Cyclic Coronary Occlusion After Thrombolysis
Authors: Gregory D. Lewis, Christian Witzke, Pedro Colon-Hernandez, J. Luis Guerrero, Kenneth D. Bloch, Marc J. Semigran
Journal: Journal of the American College of Cardiology (2006)
Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13
Authors: Suzan Imren, Michael Heuser, Maura Gasparetto, Philip A. Beer, Gudmundur L. Norddahl, Ping Xiang, Ling Chen, Tobias Berg, Garrett W. Rhyasen, Patricia Rosten, Gyeongsin Park, Yeonsook Moon, Andrew P. Weng, Connie J. Eaves, R. Keith Humphries
Journal: Blood (2014)