Normalization of Intracellular Calcium: A Sweet Solution to Neutrophil Dysfunction in Diabetes?
Authors: Matthew Bidwell Goetz
Journal: Annals of Internal Medicine (1995)

Editorials15 December 1995Normalization of Intracellular Calcium: A Sweet Solution to Neutrophil Dysfunction in Diabetes?Matthew Bidwell Goetz, MD, FACP and Richard A. Proctor, MD, FACPMatthew Bidwell Goetz, MD, FACPFrom West Los Angeles Veterans Affairs Medical Center, UCLA School of Medicine, Los Angeles, CA 90073University of Wisconsin Medical School, Madison, WI 53696.Search for more papers by this author and Richard A. Proctor, MD, FACPFrom West Los Angeles Veterans Affairs Medical Center, UCLA School of Medicine, Los Angeles, CA 90073University of Wisconsin Medical School, Madison, WI 53696.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-12-199512150-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The diapedesis of the white corpuscles, their migration through the vessel wall into the tissues, is one of the principal means of defense possessed by the animal.As soon as the infective agents have penetrated into the body, a whole army of white corpuscles proceed towards the menaced spot, there entering into a struggle with the microorganisms.… The leukocytes, having arrived at the spot where the intruders are found, seize them after the manner of Amoebae and within their bodies subject them to intracellular digestion.Ilya I'litch Metchnikoff (1882)The increased susceptibility of persons with diabetes mellitus to complicated soft-tissue, urinary tract, ...References1. 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Effect of treatment of hemodialysis patients with nifedipine on metabolism and function of polymorphonuclear leukocytes. Am J Kidney Dis. 1995;25:440-4. CrossrefMedlineGoogle Scholar17. Goetz MB, Kuriyama SM, Silverblatt FJ. Phagolysosome formation by polymorphonuclear neutrophilic leukocytes following ingestion of Escherichia coli which express type 1 pili. J Infect Dis. 1987;156:229-33. CrossrefMedlineGoogle Scholar18. Weiss J, Kao L, Victor M, Eslbach P. Oxygen-independent intracellular and oxygen-dependent extracellular killing of Escherichia coli S15 by human polymorphonuclear leukocytes. J Clin Invest. 1985;76:206-12. CrossrefMedlineGoogle Scholar19. Simchowitz L, Spilberg I. Generation of superoxide radicals by human peripheral neutrophils activated by chemotactic factor: evidence for the role of calcium. J Lab Clin Med. 1979;93:583-93. MedlineGoogle Scholar20. The Diabetes and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications of insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-86. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Matthew Bidwell Goetz, MD, FACP; Richard A. Proctor, MD, FACPAffiliations: From West Los Angeles Veterans Affairs Medical Center, UCLA School of Medicine, Los Angeles, CA 90073University of Wisconsin Medical School, Madison, WI 53696.Corresponding Author: Matthew Bidwell Goetz, MD, Chief, Infectious Diseases, West Los Angeles Veterans Affairs Medical Center (111F), 11301 Wilshire Boulevard, Los Angeles, CA 90073. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPolymorphonuclear Leukocytes in Non-Insulin-dependent Diabetes Mellitus: Abnormalities in Metabolism and Function Jadwiga M. Alexiewicz , Dinesh Kumar , Miroslaw Smogorzewski , Mariusz Klin , and Shaul G. Massry Metrics Cited bySocio-epidemiological and land cover risk factors for melioidosis in Kedah, Northern MalaysiaImpaired neutrophil store-mediated calcium entry in Type 2 diabetesDiabetic patients have a decreased incidence of acute respiratory distress syndrome 15 December 1995Volume 123, Issue 12Page: 952-954KeywordsAdenosine triphosphateAttentionBloodDiabetes mellitusGlucoseHyperglycemiaIngestionInsulinNeutrophilsPhagocytosis ePublished: 15 August 2000 Issue Published: 15 December 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...