tbuckley/cabot-search huggingface dataset:
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function
Authors: Natalie C Jones, Megan L Lynn, Karin Gaudenz, Daisuke Sakai, Kazushi Aoto, Jean-Phillipe Rey, Earl F Glynn, Lacey Ellington, Chunying Du, Jill Dixon, Michael J Dixon, Paul A Trainor
Journal: Nature Medicine (2008)
Glycosaminoglycan synthesis by cultured human hair follicle dermal papilla cells: comparison with non-follicular dermal fibroblasts
Authors: M. TAYLOR, A.T.T. ASHCROFT, G.E. WESTGATE, W.T. GIBSON, A.G. MESSENGER
Journal: British Journal of Dermatology (1992)

The extracellular matrix of the hair follicle dermal papilla is rich in glycosaminoglycans, the expression of which varies during the hair growth cycle being maximal in anagen and becoming undetectable as the follicle enters telogen. These observations, together with other experimental and clinical evidence, suggest that glycosaminoglycans may be involved in regulating hair growth. To investigate the metabolism of glycosaminoglycans by the dermal papilla we have measured the incorporation of radiolabelled precursors into glycosaminoglycans released into extracellular matrix and culture medium by cultured human dermal papilla cells. We also studied glycosaminoglycan synthesis by cells cultured from the lower follicular connective tissue sheath and by non‐follicular dermal fibroblasts. Compared with dermal fibroblasts, dermal papilla cells showed a three to fourfold higher level of incorporation of 35S‐sulphate and 3H‐glucosamine into extracellular matrix glycosaminoglycans. Dermal papilla cells also released more 3H‐glucosamine‐labelled glycosaminoglycan into culture medium than dermal fibroblasts but there was no difference in 35S‐sulphate labelling. These findings indicate that dermal papilla cells maintain a high level of glycosaminoglycan synthesis in vitro. Specific enzyme/chemical degradation showed that dermal papilla cells and dermal fibroblasts synthesized the same glycosaminoglycan types. However, the results suggested that dermal papilla glycosaminoglycans are less sulphated than those synthesized by dermal fibroblasts and that a higher proportion of sulphated glycosaminoglycans is retained in an extracellular matrix. The synthesis of glycosaminoglycans by connective tissue sheath cells was similar to that of dermal papilla cells, supporting the view that the dermal papilla and connective tissue sheath share certain properties.
The Drosophila Amidase PGRP-LB Modulates the Immune Response to Bacterial Infection
Authors: Anna Zaidman-Rémy, Mireille Hervé, Mickael Poidevin, Sébastien Pili-Floury, Min-Sung Kim, Didier Blanot, Byung-Ha Oh, Ryu Ueda, Dominique Mengin-Lecreulx, Bruno Lemaitre
Journal: Immunity (2006)
Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells
Authors: X.-P. Xu, J. S. Pollock, M. A. Tanner, P. R. Myers
Journal: Cardiovascular Research (1995)

Objective: Hypoxia significantly alters vascular tone in coronary resistance arterioles during prolonged ischemia, potentially through the modulation of endothelial cell metabolism as well as endothelial function. The objective of this study was to test the hypothesis that constitutive nitric oxide synthase (cNOS) is sensitive to oxygen tension and that hypoxia increases the activity of cNOS and nitric oxide production in the porcine coronary microcirculation. Methods: Monocultures of porcine coronary resistance arteriolar endothelial cells (RAEC) were isolated and proven to be endothelium based upon morphology, binding of acetylated LDL, and factor VIII antigen positivity. Cells were exposed to either hypoxia (pO2 = 10 mmHg) or normoxia (pO2 = 160 mmHg) for varying periods of time. Nitric oxide production was directly measured using a chemiluminescence method, while cNOS enzyme activity was assayed using a fibroblast-report cell method. cNOS protein was quantitated by Western blot analysis using the H32 monoclonal antibody to the endothelial cell constitutive isoform of NOS. Results: Hypoxia significantly augmented A23187-stimulated nitric oxide production [23.77 (1.73) vs 14.94 (0.66) nmol · μg−1 protein, hypoxia vs. normoxia respectively, n = 8, P < 0.01]. Using the fibroblast reporter cell assay, cNOS activity was increased in RAEC after exposure to hypoxia for 30, 120 and 240 min [normoxia control: 0.16 (0.04) fmol · μg−1 protein; hypoxia: 30 min = 1.00 (0.19), 120 min = 1.08 (0.04), 240 min = 1.26 (0.07) fmol · μg−1 protein (n = 6, p < 0.01)]. Western blots showed a single band at 135 kDa that was increased in homogenates of cells previously exposed to hypoxia. Conclusions: These experiments demonstrated that the regulation of cNOS is sensitive to oxygen tension. Hypoxia significantly activated constitutive nitric oxide synthase in coronary resistance arteriolar endothelial cells, and this was translated to an increased production of nitric oxide.
Abstract PD04-05: Prognostic Value of Circulating Tumor Cells According to Immunohistochemical Defined Molecular Subtype in Advanced Breast Cancer Patients
Authors: E Munzone, E Botteri, F Nolè, A Esposito, L Adamoli, L Zorzino, A Sciandivasci, MC Cassatella, A Goldhirsch, N Rotmensz, MT. Sandri
Journal: Cancer Research (2010)

Abstract Background: Breast cancer (BC) is not a single disease with variable morphologic features and biomarkers but, rather, a group of molecularly distinct neoplastic disorders. Four main molecular classes of BC have been distinguished by gene expression profiling, called luminal-A, luminal-B, HER2-positive and triple-negative (TN) cancers. These subgroups correspond reasonably well to clinical characterization on the basis of estrogen receptor (ER) and HER2 status, as well as proliferation markers or histologic grade. Correlating circulating tumor cells (CTCs) with molecular subtypes might identify subgroup of patients (pts) at different risks and groups that might benefit more from prognostic evaluation by CTCs. Patients and methods: We retrospectively analyzed 187 consecutive metastatic BC pts who had baseline CTCs enumeration performed between March 2005 and December 2009 by CellSearch. Pts were categorized in 3 prognostic groups in accordance to the number of CTCs, 0 CTC, &amp;lt;5 CTCs and ≥5 CTCs, and in 4 categories based on the tumour biology: luminal-A with ER &amp;gt;1%, any progesterone receptor (PgR), G1/G2, Ki67&amp;lt;30%; luminal-B with ER &amp;gt;1%, any PgR, G3, Ki67&amp;gt;30%; HER-2 positive with HER-2 overexpressed or FISH amplified; TN with both ER and PgR 0% and HER-2 not overexpressed/FISH not amplified. Kaplan-Meier method for survival analysis was used. Results: Median age at baseline was 56 years (range 31-78). CTCs were a strong predictive factor for overall survival (OS) in all pts (Log-Rank P&amp;lt;0.001), in pts with bone metastases (MTS) only (n=43; p=0.045), visceral MTS only (n=42; borderline significant p=0.08) and both bone and visceral MTS (n=74; P&amp;lt;0.001). The same figure was not observed in the few pts with only soft tissue MTS (n=28; p=0.315). Sixty-one (33%) pts had Luminal-A tumour, 58 (31%) Luminal-B, 53 (28%) HER-2 positive and 15 (8%) TN. CTCs were a significant prognostic factor in all molecular subtypes as shown in Figure 1. Conclusion: This large series confirms CTCs as an important prognostic factor for metastatic BC in all different molecular subtypes, but pts with 0 CTCs at baseline and TN or luminal B tumors seem to perform better as compared to other categories. Furthermore, pts with metastatic disease including bone and/or visceral sites benefited most from CTCs prognostic evaluation. Further studies with larger series and longer follow-up time could help identify metastatic BC subgroups in which CTCs analysis would be particularly useful and should be recommended. Figure available in online version. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD04-05.
Angiotensin Receptor-1 Blocker Inhibits Atherosclerotic Changes and Endothelial Disruption of the Aortic Valve in Hypercholesterolemic Rabbits
Authors: Kumiko Arishiro, Masaaki Hoshiga, Nobuyuki Negoro, Denan Jin, Shinji Takai, Mizuo Miyazaki, Tadashi Ishihara, Toshiaki Hanafusa
Journal: Journal of the American College of Cardiology (2007)
ENDOCARDIAL DYSFUNCTION IN PATIENTS WITH PRESERVED EJECTION FRACTION AFTER ANTHRACYCLINE THERAPY AS ASSESSED BY 3D SPECKLE-TRACKING AREA STRAIN
Authors: Tatsuya Miyoshi, Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Yoshiki Yamadori, Takuma Sawa, Junichi Imanishi, Yoshiki Motoji, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Tetsuari Onishi, Hironobu Minami, Hiroya Kawai, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2013)
REPORT OF THE COMMITTEE ON PHARMACOLOGIC INVESTIGATION.
Authors: H. H. RUSBY
Journal: JAMA (1897)

The trade-mark proprietary medicine purveyors do not want any analysis of their preparations to appear in the journals or text-books, and threaten prosecution to those who publish this information.To show their animus toward pharmacists, I may refer to arti- cles which they have had published in the public press, stating that the druggists are unreliable and not to be trusted, and will put up their own drugs, which are inferior, the only relia- ble product being the proprietary preparations.
DIAGNOSIS AND TREATMENT OF DISEASES OF THE SEMINAL VESICLES
Authors: WILLIAM ROBERT DELZELL
Journal: JAMA (1924)

One of the first surgical aims in treating pus infections of the body is to secure good drainage. At times it is not practical to apply this principle, and excision of the infected part is necessary. Further help is often obtained by the use of antiseptics in combating the invading organism, although it is most important to establish good drainage before help from antiseptics can be anticipated.  These general principles apply to infected seminal vesicles. It is our purpose in presenting this paper to emphasize the fact that drainage of the seminal vesicles may be acelerated by dilation of the ejaculatory ducts through the urethra. Belfield1and his followers have described the occurrence of stricture of the ejaculatory ducts as seen by roentgenograms taken of the seminal vesicles and ducts injected through the vas deferens; the condition has also been seen at necropsy. The ducts at times are also
Abstract P1-05-20: Fluorescent Hyaluronan Probes Distinguish Heterogeneous Breast Cancer Cell Subsets and Predict their Invasive Behavior
Authors: M Veiseh, DH Kwon, AD Borowsky, C Toelg, H Leong, J Lewis, EA Turley, MJ Bissell
Journal: Cancer Research (2012)

Abstract Background: Tumor heterogeneity is a determining factor in diagnosis and therapy of breast cancer (Bca). We investigated Bca cellular heterogeneity by a functional fluorescent hyaluronan (HA) probe, and monitored its binding characteristics in relation to the degree of Bca aggression. HA is a polysaccharide ligand for CD44 and RHAMM receptors, which are linked to cell plasticity and predict poor clinical outcome in Bca. Methods: Fluorescent HA probes, multiplexed profiling, and cell sorting strategies were developed and used to detect/capture tumor cell subpopulations with differences in HA binding (HA−/low vs. HAhigh) and HA receptors surface display. Whereas we concentrated on the most metastatic cell line, MDA-MB-231, we also monitored the presence of subpopulations in other Bca lines and showed heterogeneity in all. Results: The HA probe binding was highly heterogeneous, and the highest binding level was detected in highly invasive triple-negative basal subtypes such as MDA-MB-231. HA probes bound to the cell surface but also accumulated in cytoplasm and nucleus. Binding levels were dramatically reduced upon ‘reversion’ of highly malignant cells to a non-malignant phenotype in three-dimensional cultures, suggesting that the level of cellular binding to fluorescent HA probe provides a measure of malignant behavior. Comparison between HAhigh and HA−/low subpopulations revealed surprising differences in morphology, proliferation and invasion in culture, which were retained in two in vivo models. HAhigh subpopulations exhibited higher levels of invasion but surprisingly lower levels of proliferation compared to either unsorted parental cells or the HA−/low subpopulation. Conclusions: Querying HA binding in Bca lines reveals an unexpected heterogeneity with respect to tumor phenotype in vivo, morphology in 3D, invasion and proliferation. These results may aid in diagnosis and therapy of invasive Bca subpopulations and early sorting of cancer patients needing intensive chemotherapy. Keywords: Heterogeneity, 3D cultures, Hyaluronan, CD44, RHAMM/HMMR, Tumor phenotype, Breast cancer, Invasion. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-05-20.
Comparison of injection techniques for shoulder pain: results of a double blind, randomised study.
Authors: G R Hollingworth, R M Ellis, T S Hattersley
Journal: BMJ (1983)

Seventy seven patients with soft tissue shoulder lesions including adhesive capsulitis and disorders of the rotator cuff and acromioclavicular joint were admitted to a trial comparing two different methods of corticosteroid injection with local anaesthetic in a randomly allocated double blind study. The method of anatomical injection after diagnosis by the technique of selective tissue tension gave 60% success compared with the method using tender or trigger point localisation, giving 20% success (p less than 0.001).
Long-Term Results of Endoscopic Injection of Botulinum Toxin in Elderly Achalasic Patients with Tortuous Megaesophagus or Epiphrenic Diverticulum
Authors: T. Wehrmann, H. Kokabpick, V. Jacobi, H. Seifert, B. Lembcke, W. F. Caspary
Journal: Endoscopy (1999)

Achalasia is characterized by aperistalsis of the tubular esophagus and a failure of the lower esophageal sphincter (LES) to relax, because of selective loss of inhibitory neurons of the myenteric plexus [1]. Since the first use of bougienage in 1672, the treatment of achalasia has been aimed at reducing the contractile LES forces. Today this is done preferentially by pneumatic dilation or cardiomyotomy [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. While the results of cardiomyotomy are particularly favorable in younger patients, at present enforced pneumatic dilation is considered to be the standard treatment for older achalasia patients [1] [7] [8] [10] [11]. The procedure, however, carries a significant risk of esophageal perforation, which may become a problem in elderly patients with concomitant illness [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Additionally, the risk of perforation during pneumatic dilation may be increased in the presence of a tortuous megaesophagus and/or an epiphrenic diverticulum. Therefore, elderly achalasia patients with concomitant illness and epiphrenic diverticula or a tortuous megaesophagus seem to be the best candidates for alternative forms of treatment.
Peripheral Vascular Lesion in Diabetes Mellitus
Authors: J. M. Moore, I. D. O. Frew
Journal: BMJ (1965)

This report gives the results of a histological study of the blood-vessels of the skin of the leg; amputated limbs and skin biopsies were examined and the findings were then correlated with the results of previous clinical assessment.Lesions of the feet occur much more commonly in diabetics than in non-diabetics.Bell (1957), in a necropsy series of 52,062 cases, found that the incidence of gangrene was increased 53 times in male diabetics and 71 times in females.It used to be assumed that the cause was a greater liability
Pregnant Woman Presenting with a Gross Retroperitoneal Mass: Surgical Treatment with Caval Replacement
Authors: Roberto Bertini, Nazareno Suardi, Enrico M. Marone, Marco Roscigno, Giovanni Petralia, Elena Strada, Andrea Cestari, Gianluigi Arrigoni, Giorgio Guazzoni, Francesco Montorsi, Roberto Chiesa, Patrizio Rigatti
Journal: European Urology (2008)
Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation
Authors: Philippe Armand, Haesook T. Kim, Brent R. Logan, Zhiwei Wang, Edwin P. Alyea, Matt E. Kalaycio, Richard T. Maziarz, Joseph H. Antin, Robert J. Soiffer, Daniel J. Weisdorf, J. Douglas Rizzo, Mary M. Horowitz, Wael Saber
Journal: Blood (2014)
Controlled Trial of Propranolol in Hypertension
Authors: F. J. Zacharias, K. J. Cowen
Journal: BMJ (1970)

A trial of oral propranolol as a hypotensive agent was designed to provide adequate treatment periods. Twenty-eight patients with essential hypertension, with a mean blood pressure of 190/111 mm. Hg, were controlled on 120-320 mg. of propranolol daily. Their mean treated blood pressure was 153/91. They then entered, on a randomized and double-blind basis, a cross-over trial of two 16-week periods, blood pressure being measured fortnightly. Propranolol caused a statistically significant fall in blood pressure when compared with placebo. When propranolol was withdrawn blood pressures rapidly rose to hypertensive levels, though not to untreated levels. No postural hypotension was found, but a small change in blood pressure levels on exercise was noted.
Preterm Birth, Long-term Survival, and Fertility
Authors: Gerald Liew
Journal: JAMA (2008)

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381 Hepatitis delta virus proteins P24 and P27 suppress hepatitis B virus (HBV) replication by trans repressing HBV enhancers 1 and 2, and by activating the alpha IFN-inducible MXA gene
Authors: V. Williams, C. Peltekian, C. Sureau, P. Deny, E. Gordien
Journal: Journal of Hepatology (2004)
Simultaneous intradermal testing with hymenoptera venoms is safe and more efficient than sequential testing
Authors: B. Strohmeier, W. Aberer, D. Bokanovic, P. Komericki, G. J. Sturm
Journal: Allergy (2013)

Abstract Background According to current guidelines, skin testing for hymenoptera venom allergy should be performed in a stepwise manner, maintaining 15‐ to 20‐min intervals between the injections of venom. Given the long‐winded procedure of sequential skin testing, we retrospectively explored the safety of simultaneous intradermal testing. Methods Four hundred and seventy‐eight consecutive patients with a convincing history of an anaphylactic reaction after a hymenoptera sting were tested. All venom concentrations (0.02 ml of 0.001, 0.01, 0.1, and 1.0 μg/ml of honey bee and wasp venom) were administered simultaneously to the skin. Results Four hundred and seventy‐two (98.7%) patients tolerated the simultaneous intradermal test without any side‐effects. Only three subjects (0.6%) had a presumed allergic reaction during the test; another three reactions were considered vasovagal. Conclusion Our skin test protocol with four simultaneously injected concentrations of two hymenoptera venoms is safe and permits the investigator to draw rapid conclusions about the individual's sensitization pattern.
Tip of the iceberg?
Authors: Geoffrey C. Nguyen
Journal: Gut Microbes (2012)

Inflammatory bowel disease (IBD) patients have risk factors for acquisition of antibiotic-resistant organisms such as MRSA. In a recent study, we have shown a rising prevalence of MRSA infection among hospitalized IBD patients. This population is at increased risk of infection and its associated mortality. These findings underscore the need for infection control measures in the hospital setting.
Myelotoxicity of gold.
Authors: A G Kay
Journal: BMJ (1976)

Of 55 patients who developed blood dyscrasias attributable to gold treatment 15 with bone marrow hypoplasia died. A few of the dyscrasias, occurring in patients who had taken a low total dose of sodium aurothiomalate, may have resulted from immune hypersensitivity, but most, occurring in patients who had taken a higher total dose, were due to cumulative toxicity. All patients receiving gold treatment should undergo frequent blood counts. Any pronounced or continuing fall in the counts is a warning of toxicity, and gold treatment should be stopped. Treatment should be resumed only with caution, and in some patients already in remission lower doses may be just as effective in controlling the disease.
Gall stones in a Danish population: fertility period, pregnancies, and exogenous female sex hormones.
Authors: T Jorgensen
Journal: Gut (1988)

From a cross sectional study of gall stone disease ascertained by ultrasonography, the prevalence in relation to age at menarche, use of oral contraceptives, childbirths, breastfeeding, abortions, age at menopause, and menopausal hormone therapy was assessed. The random sample comprised 2301 women of Danish origin aged 30, 40, 50, and 60 years, of whom 1765 (77%) attended the investigation. Gall stone disease was significantly associated with young age at menarche, abortions, and multiple childbirth. Use of oral contraceptives was significantly associated with gall stone disease in univariate analysis, but not in multivariate analysis. Breastfeeding, age at menopause and menopausal hormone therapy were not associated with gall stones. These determining variables seemed sufficient to explain the higher prevalence of gall stone disease in women than in men.