tbuckley/cabot-search huggingface dataset:
TCT-577 Revascularization Strategies for Patients with Multiple Vessel Coronary Disease and Unprotected left main. Mid term Results from a Prospective, Multicenter and Controlled Argentina Registry with a Cobalt- Chromium Rapamycin Eluting Stent, FIREBIRD 2® (ERACI 4)
Authors: Carlos Fernandez-Pereira, Ignacio Rifourcat, Juan Mieres, Carlos Haiek, Omar Santaera, Miguel Larribau, Juan Lloberas, Ricardo Sarmiento, Antonio Pocovi, David Antoniucci, Alfredo Rodriguez
Journal: Journal of the American College of Cardiology (2014)
PAPILLOMATA OF LARYNX IN CHILDREN.
Authors: EDWARD T. DICKERMAN
Journal: JAMA (1900)

Papillomata of the larynx is undoubtedly the most frequent neoplasm found in the larynx of children, where fortunately pathologic growths are not of frequent occurrence. In an article by Rosenberg,<sup>1</sup>of Berlin, he states that out of 5808 children under 13 years of age, 16 cases of papillomata were found, that is, 1 in 363 cases examined. Schrötter found the ratio about 1 in 700, Baumgarten states the condition was rare in his clinic. In my own clinic I find the disease occurring once in about every 1200 cases. It has been my fortune to see 5 of these cases, 3 in private and 2 in clinical practice, the histories of which I shall briefly relate: <h3>Case 1.</h3> —In March, 1896, a little girl, aged 6 years, was brought from Montana to consult Dr. M. R. Brown, of this city. At the time, Dr. Brown was unable to take
Late Prognosis of Acute Pulmonary Embolism
Authors: John A. Paraskos, S. J. Adelstein, Roger E. Smith, Frank D. Rickman, William Grossman, Lewis Dexter, James E. Dalen
Journal: New England Journal of Medicine (1973)

Sixty consecutive patients who survived an episode of acute pulmonary embolism documented by pulmonary angiography were assessed one to seven years later (average follow-up period, 29 months) to determine long-term prognosis. Thirty-nine were alive, 19 (32 per cent) had died, and two were lost to follow-up study. Survival largely depended on cardiac status before embolism. Of 42 patients without left ventricular failure, 36 survived. However, of 16 with failure before embolism, only three survived. Follow-up lung scans and arterial-blood gases in the survivors and autopsy in those who died demonstrated resolution of embolism in most patients. Of 43 with adequate follow-up data, resolution was complete in 28 (65 per cent) and partial in 10 (23 per cent); unresolved embolism persisted in only five patients (12 per cent), with resultant chronic cor pulmonale in only one. Recurrent embolism was documented in only one. The long-term prognosis of patients who survive acute embolism thus appears to be dependent on the presence or absence of prior heart disease. (N Engl J Med 289:55–58, 1973)
HDAC Inhibitors and Cardiac Safety
Authors: Rhoda Molife, Peter Fong, Michelle Scurr, Ian Judson, Stan Kaye, Johann de Bono
Journal: Clinical Cancer Research (2007)

To the Editors: Shah et al. ([1][1]) reported on the cardiotoxicity of the histone deacetylase inhibitor Romidepsin (depsipeptide, FK228) administered weekly ×3 q28, in 15 patients with metastatic neuroendocrine tumors. The study was terminated early due to a high number of “serious cardiac
Pancreatic Cholera
Authors: Michael Field, Eugene B. Chang
Journal: New England Journal of Medicine (1983)

The intestinal tract is the most powerful secretory organ of the human body. An adult with cholera, for example, may excrete more than 1 liter of fluid per hour. The offending organism in cholera elaborates an enterotoxin that attaches to intestinal epithelial cells and permanently activates the enzyme adenylate cyclase, which converts ATP to cyclic AMP. The cyclic AMP that accumulates intracellularly both inhibits the absorption and stimulates the secretion of salt and water.But why is this immense secretory capacity present in an organ whose primary purpose is to absorb? Secretion, finely regulated, is probably important to normal intestinal . . .
Withdrawal of Diazepam-Reply
Authors: David Haskell
Journal: JAMA (1976)

<h3>In Reply.—</h3> Dr Paulshock's letter raises an important point: that it may be extremely difficult to distinguish between diazepam withdrawal symptoms and recurrence of the original anxiety. Several characteristics of the patients described led me to conclude that tolerance to diazepam and withdrawal reaction had in fact occurred. All of these patients had symptoms while taking diazepam in the usual therapeutic dosage, which could be relieved temporarily by increasing the dose. Other features were the more-than-usual tendency of these patients to somaticize their distress and, in particular, the constancy over time of the symptoms within each individual. In my experience, primary anxiety— not secondary to any medication— waxes and wanes and is likely to increase or diminish depending on stress. In the diazepam-dependent patients, stress did not affect symptoms. A further point pertaining to Dr Paulshock's statement about anxiety "ultimately relieved... within the protective confines of a psychiatric institution" is
Hepatoma Metastasis to Bone
Authors: Gurdip S. Sidhu
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Suffett et al (<b>215</b>:120, 1971) in reference to an article by Reichbach et al<sup>1</sup>on osseous metastases of hepatoma reported a tumor that had metastasized to a rib. They suggest that osseous metastases from hepatomas are very uncommon. This is not really the case, as various authors<sup>2-5</sup>have reported an incidence ranging from 1.6% to 12% in their series. What is in fact true is that a bony metastasis as the major presenting clinical complaint is rare.<sup>6</sup>I present a case of this latter type. The histopathological features are to be published in detail elsewhere. <h3>Report of a Case.—</h3> A 79-year-old man was admitted to the Manhattan VA Hospital with severe pain over the left scapula and left lateral part of the chest wall of six weeks' duration. There was also a chronic cough and recent clubbing of the fingers. He had smoked
Discordance Among Transient Elastography, Aspartate Aminotransferase to Platelet Ratio Index, and Histologic Assessments of Liver Fibrosis in Patients With Chronic Hepatitis C
Authors: Naveen Gara, Xiongce Zhao, David E. Kleiner, T. Jake Liang, Jay H. Hoofnagle, Marc G. Ghany
Journal: Clinical Gastroenterology and Hepatology (2012)
Abstract 401: CD5+CD23+ leukemic cell populations in Tcl1 transgenic mice show significantly increased proliferation and Akt phosphorylation
Authors: Alexey A. Efanov, Nicola Zanesi, Vadim Maximov, Natalya Nazaryan, Urmila Santanam, Alexey Palamarchuk, Carlo M. Croce, Yuri Pekarsky
Journal: Cancer Research (2010)

Abstract B-cell chronic lymphocytic leukemia (B-CLL) is the most common human leukemia. Deregulation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene in mouse B-cells causes a CD5 positive leukemia similar to aggressive human B-CLLs. We recently reported that TCL1 expression in B-CLL is regulated by miR29 and miR181. To determine whether treatment with microRNAs can inhibit B-CLL in mice by targeting TCL1 we generated TCL1 transgenic mice using a construct containing 3’ and 5’ UTRs of TCL1 under B-cell specific Eμ promoter (Eμ-TCL1fl). At the age of 12-18 months these mice showed B-CLL like disease. Immunophenotyping revealed accumulation of CD5+CD23+B220+ population in spleens and lymph nodes. Our results show that CD5+CD23+ B-cell populations from Eμ-TCL1fl mice actively proliferate and display significantly increased levels of phospho-Akt. Eμ-TCL1fl mice showed immunological abnormalities similar to human B-CLL, including hypoimmunoglobulinemia, abnormal levels of cytokines, and impaired immune response. These findings revealed biochemical and immunological similarities between Tcl1 driven B-CLL in mice and human B-CLL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 401.
Abstract P6-14-01: Effect of Denosumab Versus Zoledronic Acid Treatment in Patients with Breast Cancer and Bone Metastases: Results from the Extended Blinded Treatment Phase
Authors: A Stopeck, M Martin, D Ritchie, J-J Body, A Paterson, M Viniegra, J Jassem, T Takano, C Van Poznak, H Bourgeois, M Fan, R Dansey, A. Braun
Journal: Cancer Research (2010)

Abstract Background: Denosumab is a fully human monoclonal antibody which inhibits RANKL, a key mediator of osteoclast activity. Results from the primary analysis of this pivotal phase 3 trial showed that denosumab was superior to zoledronic acid (ZA) in delaying the time to first on-study skeletal-related events (SRE) in patients with breast cancer and bone metastases. We now report results including an additional 4 months of blinded treatment. Methods: Randomized patients received either subcutaneous (SC) denosumab (120 mg) and intravenous (IV) placebo or IV ZA (4 mg, adjusted for renal function) and SC placebo every 4 weeks. No dose adjustments were made for SC denosumab. All patients were advised to take daily calcium (≥500 mg) and vitamin D (≥400 IU) supplements. The primary endpoint was time to first on-study SRE (predefined as pathologic fracture, radiation or surgery to bone, or spinal cord compression). Time to first and subsequent SRE (multiple event analysis) and safety endpoints were also evaluated. Analyses for the extended treatment phase are considered exploratory. Results: Overall, 2046 patients enrolled: 1026 were randomized to denosumab and 1020 were randomized to ZA. Denosumab was superior to ZA in delaying the time to first on-study SRE by 18%, and the time to first and subsequent on-study SRE by 22% (Table). The median time to first on-study SRE was 5 months longer for the denosumab group (32.4 months) than the ZA group (27.4 months). Overall survival and disease progression were similar for both treatment groups. Similar percentages of subjects reported adverse events (AEs; 96.2% denosumab, 97.4% ZA) and serious AEs (47.9% denosumab, 50.2% ZA). Positively adjudicated cases of osteonecrosis of the jaw were reported in 2.5% (n=26) of denosumab-treated patients and 1.8% (n=18) of ZA-treated patients (P=0.29). Hypocalcemia was reported by 62 (6.1 %) patients in the denosumab group and 37 (3.7%) patients in the ZA group. Conclusion: Among patients with breast cancer and bone metastases, denosumab was superior to ZA in delaying or preventing SREs, and continued treatment with denosumab resulted in a median time to first SRE that was 5 months longer than treatment with ZA. Denosumab, with its novel mode of action, may represent a potential treatment option for patients with breast cancer and bone metastases without the need for dose adjustment or renal monitoring. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-14-01.
Ethical Foundations of Health System Reform-Reply
Authors: Dan Brock
Journal: JAMA (1994)

<h3>In Reply.</h3> —A Dr McCullough notes, we did not cite empirical surveys to back our claim that the principles and values underlying the Clinton reform were "widely shared." We took it as a commonplace that many polls over the years show Americans strongly believe that no one should go without needed medical services and that it is a social responsibility to provide them to those who cannot afford them. The values and principles are also "widely shared" in that they are supported by many religious and moral traditions and theories. We did not suggest they were universally accepted. Nor should anyone infer that these are not widely shared American values just because our health care system does not yet embody them: many powerful interests oppose the achievement of reform now and have successfully thwarted it in the past. Because the Ethics Working Group of President Clinton's Health Care Task Force
A Noninvasive Procedure for Early-Stage Discrimination of Malignant and Precancerous Vocal Fold Lesions Based on Laryngeal Dynamics Analysis
Authors: Jakob Unger, Jörg Lohscheller, Maximilian Reiter, Katharina Eder, Christian S. Betz, Maria Schuster
Journal: Cancer Research (2014)

Abstract About two thirds of laryngeal cancers originate at the vocal cords. Early-stage detection of malignant vocal fold alterations, including a discrimination of premalignant lesions, represents a major challenge in laryngology as precancerous vocal fold lesions and small carcinomas are difficult to distinguish by means of regular endoscopy only. We report a procedure to discriminate between malignant and precancerous lesions by measuring the characteristics of vocal fold dynamics by means of a computerized analysis of laryngeal high-speed videos. Ten patients with squamous cell T1a carcinoma, ten with precancerous lesions with hyperkeratosis, and ten subjects without laryngeal disease underwent high-speed laryngoscopy yielding 4,000 images per second. By means of wavelet-based phonovibrographic analysis, a set of three clinically meaningful vibratory measures was extracted from the videos comprising a total number of 15,000 video frames. Statistical analysis (ANOVA with post hoc two-sided t tests, P &amp;lt; 0.05) revealed that vocal fold dynamics is significantly affected in the presence of precancerous lesions and T1a carcinoma. On the basis of the three measures, a discriminating pattern was extracted using a support vector machine-learning algorithm performing an individual classification in respect to the different clinical groups. By applying a leave-one-out cross-validation strategy, we could show that the proposed measures discriminate with a very high performance between precancerous lesions and T1a carcinoma (sensitivity, 100%; specificity, 100%). Although a large-scale study will be necessary to confirm clinical significance, the set of vibratory measures derived in this study may be applicable to improve the accuracy and reliability of noninvasive diagnostics of vocal fold lesions. Cancer Res; 75(1); 31–39. ©2014 AACR.
Health of juvenile delinquents.
Authors: A M Weindling, F N Bamford, R A Whittall
Journal: BMJ (1986)

Health of juvenile delinquentsIntermediate treatment centres were established in 1969 to enable delin- quent adolescents to remain within their communities under supervision, avoiding the imposition of a custodial sentence.'This study compares the physical health of a group of delinquent boys who attended Parkway, an intermediate treatment centre in a deprived inner city area, with that of non- delinquents. Subjects, methods and resultsTwenty four delinquents admitted during one year were eligible for the study.They were matched with 24 boys who were at the same school and in the same year and who lived in the same postal district.A medical history was obtained, general physical examination was performed, and hearing and vision were assessed.Student's t and the X2 test were used as appropriate.The table shows the physical and social characteristics of the boys.There was no difference in birth weight, the incidence of perinatal problems, or the number ofhospital admissions between the two groups.Urinalysis showed normal results in all cases.Smoking was more common among delinquents (p<0-01).The Physical and social characteristics ofdelinquent and non-delinquent boys. (Figures are means (SD))
The University of Toronto Concussion Symptom Scale: do initial symptoms predict outcome?
Authors: Doug Richards, Michael Hutchison, Seper Ekhtiari, Paul Comper
Journal: British Journal of Sports Medicine (2013)

Objective To explore symptoms during initial physician evaluation and time to return-to-play experienced by university level athletes. Design Prospective case series of concussions during three athletic seasons (2009–2012). Setting University of Toronto, Ontario, Canada. Subjects Athletes who sustained concussions while involved in inter-university sports (practice or competition) in the following sports: volleyball, fencing, rugby, basketball, track, hockey, soccer, cheerleading, football, lacrosse, field hockey, and figure skating. A total of 85 concussions were reported from 68 athletes (37 males, 31 females) Intervention David L. Macintosh Sport Medicine Clinic physicians documented athletes' post-concussion symptoms and recorded the date when a player was medically cleared to return to play. Main Outcome Measures Symptoms as measured by the University of Toronto Concussion Symptom Scale (UTCSS) scores, time loss from competition, loss of consciousness, amnesia, and history of concussion. Results 90.6% of athletes reported at least one symptom on the UTCSS at the first office-visit, with somatic symptoms most frequently reported. The average UTCSS score at 3 days following injury was 13.1 (range, 0–51), with female athletes reporting significantly more symptoms than males (p&lt;0.01). Time loss was not significantly different between males and females. The only factor that predicted poor outcome (&gt;14 days out) was endorsement of cognitive symptoms of the UTCSS (OR 1.30, 95% CI 1.03 to 1.68). Conclusions Female athletes reported significantly more symptoms than male athletes following concussion. Cognitive symptoms of the UTCSS were significant predictors of time loss among university level athletes. Acknowledgements The authors wish to acknowledge the David L. Macintosh Sport Medicine Clinic, The University of Toronto Varsity Blues athletes, therapists, and support staff. Competing interests None.
Smad4: gatekeeper gene in head and neck squamous cell carcinoma
Authors: Murray Korc
Journal: Journal of Clinical Investigation (2009)

Unchecked cell growth is a hallmark of cancer. During oncogenesis, cancerous cells become resistant to the TGF-beta signaling pathway that usually keeps cell growth in check. The role of a critical mediator of this pathway, Smad4, in head and neck squamous cell carcinoma (HNSCC) remains unclear. In this issue of the JCI, Bornstein and colleagues report that Smad4 expression is decreased in malignant HNSCC and, surprisingly, also in normal-appearing buccal mucosa adjacent to HNSCC (see the related article beginning on page 3408). They also show that targeted conditional deletion of Smad4 in the head and neck epithelium of mice is alone sufficient to initiate spontaneous HNSCC, in conjunction with DNA repair gene dysregulation, genetic instability, and inflammation. These findings point to a novel function for Smad4 as a guardian gene that maintains genomic stability.
DERMATITIS OF THE EYELIDS
Authors: Herbert Rattner
Journal: JAMA (1934)

The Journalhas recently contained several reports dealing with dermatitis of the eyelids caused by eyelash dye. Dermatitis of the eyelids occurs rather frequently; it is usually due to external irritants, but to determine the irritant may be difficult. An experience with four cases seen within a few days of one another prompts this note. All four patients were women who presented inflammations of varying severity, and the exciting agent in each case was different. <h3>Case 1</h3> A young woman, a manicurist, shown in the illustration, applied Godfrey's dye to her eyebrows and eyelashes and within a few hours the lids became swollen and red and itched intensely. When she was seen the next day there was severe conjunctivitis with photophobia, and the lids, eyebrow regions and adjacent portions of skin were the seat of an intense vesicular eruption. The skin was edematous and red, and she complained of severe
Claiming Power in Doctor-Patient Talk
Authors: Ann C. Klassen
Journal: Annals of Internal Medicine (1998)

Medical Writings1 December 1998Claiming Power in Doctor-Patient TalkAnn C. Klassen, PhDAnn C. Klassen, PhDJohn Hopkins University School of Public Health, Baltimore, MarylandSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-11_Part_1-199812010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Claiming Power in Doctor-Patient Talk; Ainsworth-Vaughn N. 224 pages. New York: Oxford Univ Pr; 1998. $45.00. ISBN 0195096061. Order phone 800-451-7556.Field of medicine: Sociolinguistics and medical sociology.Format: Hardcover book.Audience: Medical sociologists, ethicists, medical students and educators, and researchers in patient-health care provider communications.Purpose: To explore the content and socioemotional impact of patient–physician conversation and apply theories of sociolinguistics to medical encounters. The book also illustrates techniques of physician conversation style that are most conducive to patient satisfaction.Content: The book's eight chapters are grouped into four parts. The author first reviews existing research in analysis of ... Author, Article, and Disclosure InformationAffiliations: John Hopkins University School of Public Health, Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1998Volume 129, Issue 11_Part_1Page: 920KeywordsBehaviorMedical sociologyPrevention, policy, and public healthQuantitative analysisResearch and reporting methodsSexual identity ePublished: 15 August 2000 Issue Published: 1 December 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Gastrology: the use of culinary terms in medicine.
Authors: S I Terry, B Hanchard
Journal: BMJ (1979)

In the era of the SI unit everything in medicine is supposed to be accurately measured and standardised.Nevertheless, medicine remains essentially a descriptive science, particularly where the communication of appearance is concerned: whether abnormal physical signs, techniques of surgery, radiological shadows, or pathological abnormalities of organs or cells.The frequency with which allusions are made in medical writing to food and drink is impressive.We have culled 99 items of food and distilled 22 beverage-related items from various publications, and present an analysis of this harvest. FruitThe more delectable the fruit the more likely it is to be mentioned, although most of the references are to temperate fruits.The strawberry seems to lend itself particularly to descriptive analogy: easily remembered are the strawberry nose (rhinophyma) and naevus (cavernous haemangioma), as well as the strawberry gall bladder (cholesterolosis).In addition, a strawberry tongue is seen, with a coating, in scarlet fever; when this coating disappears-uncovering congested, oedematous papillae resulting in a darker red colour-a raspberry tongue is produced.The cutaneous lesions of secondary (framboesiform)
Fulminant Delta Hepatitis in Chronic Asymptomatic HBsAg Carriers
Authors: N. Tassopoulos
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In a recent issue ofThe Journal, De Cock et al<sup>1</sup>presented two cases of fulminant delta hepatitis in two male homosexual patients with chronic hepatitis B virus (HBV) infection. We followed up prospectively, for at least six months, 546 adults with acute sporadic hepatitis B surface antigen (HBsAg)-positive hepatitis who were hospitalized at the Athens Hospital for Infectious Diseases, Greece, between May 1981 and May 1983. Using a sensitive enzyme immunoassay (Corzyme M) for the determination of the core antigen of HBV (anti-HBc IgM) we found that 43 (7.9%) of the 546 patients were anti-HBc IgM negative. These patients were considered as asymptomatic chronic HBsAg carriers with a superimposed acute non-B hepatitis.<sup>2</sup> Twenty-two (51.2% ) of the 43 cases were diagnosed as having delta antigen superinfection, using sensitive radioimmunoassays for the detection of delta antigen, anti-delta IgG, and anti-delta IgM.<sup>3,4</sup>Homosexual promiscuity and parenteral