Etiocholanolone in the Evaluation of Marrow Reserves in Patients Receiving Cytotoxic Agents
Authors: JAMES M. VOGEL
Journal: Annals of Internal Medicine (1967)

Article1 December 1967Etiocholanolone in the Evaluation of Marrow Reserves in Patients Receiving Cytotoxic AgentsJAMES M. VOGEL, M.D., HARRY R. KIMBALL, M.D., SHELDON M. WOLFF, M.D., F.A.C.P., SEYMOUR PERRY, M.D., F.A.C.P.JAMES M. VOGEL, M.D.Search for more papers by this author, HARRY R. KIMBALL, M.D.Search for more papers by this author, SHELDON M. WOLFF, M.D., F.A.C.P.Search for more papers by this author, SEYMOUR PERRY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1226 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe administration of cytotoxic drugs for the control of neoplastic growth or immunosuppression often results in the depressed maturation of normal bone marrow elements. While drug-induced anemia and thrombocytopenia can be at least partially corrected with red cell and platelet transfusions, severe granulocytopenia and the attendant risk of bacterial and fungal infections present the greatest problem in treatment (1, 2). Leukocytes are difficult to obtain in large numbers; besides, their effectiveness has never been clearly demonstrated (3). Thus, reliable estimation of the bone marrow granulocyte mass before treatment would be a valuable adjunct to the rational use of myelosuppressive agents....References1. BODEYBUCKLEYSATHEFREIREICH GPMYSEJ: Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann. Intern. Med. 64: 328, 1966. LinkGoogle Scholar2. BODEY GP: Fungal infections complicating acute leukemia. J. Chronic Dis. 19: 667, 1966. CrossrefMedlineGoogle Scholar3. FREIREICHLEVINWHANGCARBONEBRONSONMORSE EJRHJPPWEE: The function and fate of transfused leukocytes from donors with chronic myelocytic leukemia in leukopenic patients. Ann. N. Y. Acad. Sci. 113: 1081, 1964. CrossrefMedlineGoogle Scholar4. MECHANICFREILANDYSMITH RCEMWW: Quantitative studies of human leukocytic and febrile response to single and repeated doses of purified bacterial endotoxin. J. Clin. Invest. 41: 162, 1962. CrossrefMedlineGoogle Scholar5. WOLFFRUBENSTEINMULHOLLANDALLING SMMJHDW: Comparison of hematologic and febrile responses to endotoxin in man. Blood 26: 190, 1965. CrossrefMedlineGoogle Scholar6. ATHENSHAABRAABMAUERASHENBRUCKERCARTWRIGHTWINTROBE JWOPSOAMHGEMM: Leukokinetic studies. IV. The total blood, circulating, and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J. Clin. Invest. 40: 989, 1961. CrossrefMedlineGoogle Scholar7. HEILMEYER I: A test of leukopoietic function of the bone marrow. Deutsch. Med. Wschr. 2: 683, 1957. Google Scholar8. FINKCALABRESI MEP: The granulocyte response to an endotoxin (Pyrexal) as a measure of functional marrow reserve in cancer chemotherapy. Ann. Intern. Med. 57: 732, 1962. LinkGoogle Scholar9. KIMBALLVOGELPERRYWOLFF HRJMSSM: Quantitative aspects of pyrogenic and hematologic responses to etiocholanolone in man. J. Lab. Clin. Med. 69: 415, 1967. MedlineGoogle Scholar10. VOGELYANKEEKIMBALLWOLFFPERRY JMRAHRSMS: The effect of etiocholanolone on granulocyte kinetics. Blood 30: 474, 1967. CrossrefMedlineGoogle Scholar11. KAWAKITA Y: Normal values for blood picture and bone marrow findings in Japanese individuals, in Standardization, Documentation and Normal Values in Haematology, vol. 21, edited by BOROVICZENY, CH. G. DE. S. Karger AG, Basel, 1965, p. 121. CrossrefGoogle Scholar12. BRECHERSCHNEIDERMANCRONKITE GMEP: The reproducibility and constancy of the platelet count. Amer. J. Clin. Path. 23: 15, 1953. CrossrefMedlineGoogle Scholar13. JOHNSONFOLEYSTECKELGLENN REHTRJDW: Extended radiotherapy in advanced Hodgkin's disease. Hematologic aspects. Arch. Intern. Med. (Chicago) 118: 70, 1966. CrossrefMedlineGoogle Scholar14. DEVITASERPICK VTA: Combination chemotherapy in the treatment of advanced Hodgkin's disease (abstract). Proc. Amer. Ass. Cancer Res. 8: 13, 1967. Google Scholar15. KIMBALLWOLFFVOGELPERRY HRSMJMS: Experimental etiocholanolone fever: febrile reactivity in men and women. J. Clin. Endocr. 26: 222, 1966. CrossrefGoogle Scholar16. MARSHPERRY JCS: The granulocyte response to endotoxin in patients with hematologic disorders. Blood 23: 581, 1963. CrossrefGoogle Scholar17. KIMBALLLIPSETTODELLWOLFF HRMBWDSM: Effect of pyrogens on plasma cortisol and growth hormone (abstract). Clin. Res. 15: 261, 1967. Google Scholar18. SHULMANHERRMANNPETERSDORF JAWLRG: Experimental etiocholanolone fever. J. Clin. Endocr. 24: 1136, 1964. CrossrefGoogle Scholar19. ROSENBERG SA: Report of the Committee on the Staging of Hodgkin's Disease. Cancer Res. 26: 1310, 1966. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES M. VOGEL, M.D.; HARRY R. KIMBALL, M.D.; SHELDON M. WOLFF, M.D., F.A.C.P.; SEYMOUR PERRY, M.D., F.A.C.P.Affiliations: Bethesda, MarylandFrom the Medicine Branch, National Cancer Institute, and the Clinical Physiology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.This paper was presented in part at the annual meeting of the American Federation for Clinical Research, Atlantic City, N. J., April 30, 1967.Requests for reprints should be addressed to Seymour Perry, M.D., National Cancer Institute, Bldg. 10, Room 6-B-17, National Institutes of Health, Bethesda, Md. 20014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNon-immune chronic idiopathic neutropenia of adult: an overviewEffects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteersStimulation Tests for the Bone Marrow Neutrophil Pool in MalignanciesReferencesMyelopoietic abnormalities in patients with metastatic carcinomaImpaired Marrow Granulocyte Reserve and Leukocyte Mobilization in Leukemic ReticuloendotheliosisLUNG T. YAM, M.D., AFTAB A. CHAUDHRY, M.D., ANTHONY J. JANCKILA, B.S.Granulocyte Kinetics in Health and DiseaseA phase II study of intravenously-administered methyl CCNU in the treatment of advanced sarcomasNeutrophil leukocyte reserves in lymphoreticular malignanciesGranulozytopoese Morphologie, Physiologie, Kinetik und FunktionMultiple neoplasms in two siblings with a variant form of Fanconi's anemiaStudies on the neutropenia of cancer chemotherapyGranulozytenmobilisation durch Endotoxin bei Mäusen nach Infektion mit Rauscher-VirusThe Etiocholanolone Test for Prediction of the Leukopenic Effect of Cytotoxic DrugsMarrow Granulocyte Reserves in the Rheumatic DiseasesImmunosuppressive therapy. Guidelines for drug dosage. Depression of bone marrow granulocyte reserves in systemic lupus erythematosusAppraisal of MyelopoiesisSplenectomy in Hodgkin's disease for splenomegaly, cytopenias and intolerance to myelosuppressive chemotherapyTHE USE OF ETIOCHOLANOLONE FOR THE MEASUREMENT OF MARROW GRANULOCYTE RESERVESChromosomal Aberrations in Two Cases of Inherited Aplastic Anemia with Unusual Clinical FeaturesRICHARD J. HIRSCHMAN, M.D., N. RAPHAEL SHULMAN, M.D., JULIAN G. ABUELO, M.D., JACQUELINE WHANG-PENG, M.D.Defective Granulocyte Regulation in the Chediak–Higashi SyndromeEffect of extensive radiotherapy on the marrow granulocyte reserves of patients with Hodgkin's diseaseCytologische und humorale Veränderungen bei experimentellem ÄtiocholanolonfieberThe Biological Properties of Etiocholanolone Combined Clinical Staff Conference at the National Institutes of HealthSHELDON M. WOLFF, M.D., F.A.C.P., HARRY R. KIMBALL, M.D., SEYMOUR PERRY, M.D., F.A.C.P., RICHARD ROOT, M.D., ATTALLAH KAPPAS, M.D., F.A.C.P. 1 December 1967Volume 67, Issue 6Page: 1226-1238KeywordsBone marrowClinical laboratoriesDrug regulationDrug research and developmentDrugsGranulocytesInfectious diseasesPatientsPlateletsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1967 PDF downloadLoading ...