Cost-Effectiveness and Cost-Benefit Analyses in the Medical Literature
Authors: I. Steven Udvarhelyi, Graham A. Colditz, Arti Rai, Arnold M. Epstein
Journal: Annals of Internal Medicine (1992)

Reviews1 February 1992Cost-Effectiveness and Cost-Benefit Analyses in the Medical LiteratureAre the Methods Being Used Correctly?I. Steven Udvarhelyi, MD, MSC, Graham A. Colditz, MBBS, DrPH, Arti Rai, AB, Arnold M. Epstein, MD, MAI. Steven Udvarhelyi, MD, MSC, Graham A. Colditz, MBBS, DrPH, Arti Rai, AB, Arnold M. Epstein, MD, MAAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-3-238 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptObjective: To determine whether published cost-effectiveness and cost-benefit analyses have adhered to basic analytic principles.Design: Structured methodologie review of published articles.Study Sample: Seventy-seven articles published either from 1978 to 1980 or from 1985 to 1987 in general medical, general surgical, and medical subspecialty journals.Main Outcome Measurements: Articles were reviewed to assess the use and reporting of six fundamental principles of analysis. These principles were derived by reviewing widely cited textbooks and articles describing the methods for performing economic analyses and by selecting the methods universally recommended.Main Results: Overall performance was only fair. Three articles adhered to all six principles, and the median number of principles to which articles adhered was three. Among the problems noted were failure to make underlying assumptions explicit and, therefore, verifiable, and failure to test assumptions with sensitivity analyses. No improvement in performance was observed between 1978 and 1987. Articles in general medical journals, however, were more likely to use analytic methods appropriately than articles in the general surgical or medical subspecialty literature.Conclusions:Greater attention should be devoted to ensuring the appropriate use of analytic methods for economic analyses, and readers should make note of the methods used when interpreting the results of economic analyses....References1. LazenbyLetsch HS. National health expenditures, 1989. Health Care Finance Rev. 1990;12:1-26. MedlineGoogle Scholar2. Leaf A. Cost effectiveness as a criterion for Medicare coverage. N Engl J Med. 1989;321:898-900. CrossrefMedlineGoogle Scholar3. DoubiletWeinsteinMcNeil PMB. Use and misuse of the term "cost effective" in medicine. N Engl J Med. 1986;314:253-5. CrossrefMedlineGoogle Scholar4. WarnerHutton KR. Cost-benefit and cost-effectiveness analysis in health care. Growth and composition of the literature. Med Care. 1980;17:1069-84. CrossrefGoogle Scholar5. Drummond M. Survey of cost-effectiveness and cost-benefit analyses in industrialized countries. World Health Stat Q. 1985:38:383-401. MedlineGoogle Scholar6. WeinsteinStason MW. Foundations of cost-effectiveness analysis for health and medical practices. N Engl J Med. 1977:296:716-21. CrossrefMedlineGoogle Scholar7. How to read clinical journals: VII. To understand an economic evaluation (part A). Can Med Assoc J. 1984;130:1428-34. MedlineGoogle Scholar8. How to read clinical journals: VII. To understand an economic evaluation (part B). Can Med Assoc J. 1984;130:1542-49. MedlineGoogle Scholar9. DrummondStoddartLabelleCushman MGRR. Health economics: an introduction for clinicians. Ann Intern Med. 1987;107:88-92. LinkGoogle Scholar10. Eisenberg J. Clinical economics. A guide to the economic analysis of clinical practices. JAMA. 1989;262:2879-86. CrossrefMedlineGoogle Scholar11. DetskyNaglie AI. A clinician's guide to cost-effectiveness analysis. Ann Intern Med. 1990;113:147-54. LinkGoogle Scholar12. CenterwallCriqui BM. Prevention of the Wernicke-Korsakoff syndrome: a cost-benefit analysis. N Engl J Med. 1978;299:285-9. CrossrefMedlineGoogle Scholar13. Doberneck R. Breast biopsy: a study of cost-effectiveness. Ann Surg. 1980;192:152-6. CrossrefMedlineGoogle Scholar14. EdisSheedyBeahrsvan Heerden APOJ. Results of reoperation for hyperparathyroidism, with evaluation of preoperative localization studies. Surgery. 1978;84:384-93. MedlineGoogle Scholar15. Epstein S. Value and limitations of the electrocardiographic response to exercise in the assessment of patients with coronary artery disease. Am J Cardiol. 1978;42:667-74. CrossrefMedlineGoogle Scholar16. Felman Y. Should premarital syphilis serologies continue to be mandated by law? JAMA. 1978;240:459-60. CrossrefMedlineGoogle Scholar17. FulchieroMillerFoleyBallantineAmorosino ASCHC. Can the PSRO's be cost effective? A study of the effect of the Commonwealth Health Agencies Monitoring Program on the length of stay of Medicaid patients in Massachusetts. N Engl J Med. 1979;299:574-9. CrossrefGoogle Scholar18. KoplanSchoenbaumWeinsteinFraser JSMD. Pertussis vaccine—an analysis of benefits, risks and costs. N Engl J Med. 1979;301:906-11. CrossrefMedlineGoogle Scholar19. RiosSandquistRamsethStratbuckerDrazenHanmer JFDREJ. The quest for optimal electrocardiography. Task Force V: Cost effectiveness of the electrocardiogram. Am J Cardiol. 1978:41:175-83. CrossrefMedlineGoogle Scholar20. VogelerBurke DJ. Tuberculosis screening for hospital employees. A five-year experience in a large community hospital. Am Rev Respir Dis. 1978;117:227-32. MedlineGoogle Scholar21. WalkerFosterMcKegneyMcKegney GRCF. Breast biopsy. A comparison of outpatient and inpatient experience. Arch Surg. 1978;113:942-6. CrossrefMedlineGoogle Scholar22. WolsonGoldberg AB. Gray-scale ultrasonic cholecystography. A primary screening procedure. JAMA. 1978;240:2073-5. CrossrefMedlineGoogle Scholar23. CrouchJonesKleinbeckReeceBessman MAEEA. Reuse of disposable syringe-needle units in the diabetic patient. Diabetes Care. 1979;2:418-20. CrossrefMedlineGoogle Scholar24. FarberFinkelstein MS. A cost-benefit analysis of mandatory premarital rubella-antibody screening. N Engl J Med. 1979;300:856-9. CrossrefMedlineGoogle Scholar25. FoxNunn WA. The cost of antituberculous drug regimens. Am Rev Respir Dis. 1979;120:503-9. MedlineGoogle Scholar26. LaydeVon AllmenOakley PSG. Congenital hypothyroidism control programs. A cost-benefit analysis. JAMA. 1979;241:2290-2. CrossrefMedlineGoogle Scholar27. PageCarltonAndrassyFeldtmanShield CPRRC. Safe, cost-effective postoperative nutrition. Defined formula diet via needle-catheter jejunostomy. Am J Surg. 1979;138:939-45. CrossrefMedlineGoogle Scholar28. SalvatierraFeduskaVincentiDucaPotterNolan ONFRDJ. Analysis of costs and outcomes of renal transplantation at one center. Its implications. JAMA 1979;241:1469-73. CrossrefMedlineGoogle Scholar29. SkillingsWilliamsHinshaw JJJ. Cost-effectiveness of operative cholangiography. Am J Surg. 1979;137:26-31. CrossrefMedlineGoogle Scholar30. CrosbyWellonsMartinSchuchMuller IHRDW. Employability—a new indication for aneurysmectomy and coronary revascularization. Circulation. 1980;62:179-83. Google Scholar31. DavisLefrakMillerMalt HSDS. Prolonged mechanically assisted ventilation. An analysis of outcome and charges. JAMA. 1980;243:43-5. CrossrefMedlineGoogle Scholar32. DetwilerKimLongerbeam RDJ. Ultrasonography and oral cholecystography: a comparison of their use in the diagnosis of gallbladder disease. Arch Surg. 1980;115:1096-8. CrossrefMedlineGoogle Scholar33. Goitein M. Benefits and costs of computerized tomography in radiation therapy. JAMA. 1980;244:1347-50. CrossrefMedlineGoogle Scholar34. GrandeChristiansenPedersenChristensen PCAM. Optimal diagnosis in acute myocardial infarction. A cost-effectiveness study. Circulation. 1980;61:723-8. CrossrefMedlineGoogle Scholar35. HerzMathieuCarricoMason JTJT. Simultaneous transurethral prostatectomy and herniorrhapy: A study of 63 cases. JAMA. 1980;244:586-7. CrossrefMedlineGoogle Scholar36. KoplanFarer JL. Choice of preventive treatment for isoniazid-resistant tuberculous infection. Use of decision analysis and the Delphi Technique. JAMA. 1980;244:2736-40. CrossrefMedlineGoogle Scholar37. LarsonOmennLewis EGH. Diagnostic evaluation of headache. Impact of computerized tomography and cost-effectiveness. JAMA. 1980;243:359-62. CrossrefMedlineGoogle Scholar38. O'DonnellGembarowcizCallowPaukerKellyDeterling TRASJR. The economic impact of acute variceal bleeding: cost-effectiveness implications for medical and surgical therapy. Surgery. 1980;88:693-701. MedlineGoogle Scholar39. RosensheinFarewellPriceLarsonDale MVTED. The cost effectiveness of therapeutic and prophylactic leukocyte transfusion. N Engl J Med. 1980;302:1058-62. CrossrefMedlineGoogle Scholar40. SalzmanDavies EG. Prophylaxis of venous thromboembolism: analysis of cost effectiveness. Ann Surg. 1980;191:207-18. CrossrefMedlineGoogle Scholar41. Weinstein M. Estrogen use in postmenopausal women—costs, risks, and benefits. N Engl J Med. 1980;303:308-16. CrossrefMedlineGoogle Scholar42. WillemsSandersRiddioughBell JCMJ. Cost effectiveness of vaccination against pneumococcal pneumonia. N Engl J Med. 1980;303:553-9. CrossrefMedlineGoogle Scholar43. AndersonMoser JR. Parasite screening and treatment among Indochinese refugees. Cost-benefit/utility and the General Health Policy Model. JAMA. 1985;253:2229-35. CrossrefMedlineGoogle Scholar44. BentonKerstein GM. Cost effectiveness of early digit amputation in the patient with diabetes. Surg Gynecol Obstet. 1985:161:523-4. MedlineGoogle Scholar45. Berwick D. Screening in health fairs. A critical review of benefits, risks, and costs. JAMA. 1985;254:1492-8. CrossrefMedlineGoogle Scholar46. CochiBroomeHightower SCA. Immunization of U.S. children with Hemophilus influenzae type b polysaccharide vaccine. A cost-effectiveness model of strategy assessment. JAMA. 1985:253:521-9. CrossrefMedlineGoogle Scholar47. GreenMessickRicottaCharltonSatranMcBride RWJMRM. Benefits, shortcomings, and costs of EEG monitoring. Ann Surg. 1985:785-92. CrossrefMedlineGoogle Scholar48. PittGomesLoisMannDeutschLongmire HAJLLW. Does preoperative percutaneous biliary drainage reduce operative risk or increase hospital cost? Ann Surg. 1985;201:545-53. CrossrefMedlineGoogle Scholar49. SaksenaGreenbergFerguson SED. Prospective reimbursement for state-of-the-art medical practice: the case for invasive electrophysiologic evaluation. Am J Cardiol. 1985:55:963-7. CrossrefMedlineGoogle Scholar50. SmithSafaiiFosterReinhold THER. Accuracy and cost-effectiveness of fine needle aspiration biopsy. Am J Surg. 1985:149:540-5. CrossrefMedlineGoogle Scholar51. Thibault G. Making the coronary care unit cost-effective. Am J Cardiol. 1985;56:35C-39C. CrossrefMedlineGoogle Scholar52. KirzLarsen HC. Costs and benefits of medical student training to a health maintenance organization. JAMA. 1986:256:734-9. CrossrefMedlineGoogle Scholar53. BabikianBryonHassett GRJ. Redirection of central venous pressure catheters using a flow directed technique. Surg Gynecol Obstet. 1986;163:482-4. MedlineGoogle Scholar54. BrootenKumarBrownButtsFinklerBakewell-Sachs DSLPSS. A randomized clinical trial of early hospital discharge and home follow-up very-low-birth-weight infants. N Engl J Med. 1986;315:934-9. CrossrefMedlineGoogle Scholar55. CebulPoses RR. The comparative cost-effectiveness of statistical decision rules and experienced physicians in pharyngitis management. JAMA. 1986:256:3353-7. CrossrefMedlineGoogle Scholar56. HandsfieldJasmanRobertsHansonKothenbeutelStamm HLPVRW. Criteria for selective screening for Chlamydia trachomatis infection in women attending family planning clinics. JAMA. 1986;255:1730-4. CrossrefMedlineGoogle Scholar57. KesterAndrassyAust DRJ. The value and cost effectiveness of abdominal roentgenograms in the evaluation of stab wounds to the abdomen. Surg Gynecol Obstet. 1986:162:337-9. MedlineGoogle Scholar58. EpsteinMaron SB. Sudden death and the competitive athelete: perspectives on preparticipatin screening studies. J Am Coll Cardiol. 1986;7:220-30. CrossrefMedlineGoogle Scholar59. KreisAugensteinMartinezEcheniquePlasenciaVopal DDOMGJ. A prospective randomized study of moxalactam versus gentamicin and clindamycin in penetrating abdominal trauma. Surg Gynecol Obstet. 1986;163:1-4. MedlineGoogle Scholar60. LanninSilvermannWalkerPories DJCW. Cost-effectiveness of fine needle biopsy of the breast. Ann Surg. 1986;203:474-80. CrossrefMedlineGoogle Scholar61. LiangCullenLarsonThompsonSchwartzFossel MKMMJA. Cost-effectiveness of total joint arthroplaty in osteoarthritis. Arthritis Rheum. 1986;29:937-43. CrossrefMedlineGoogle Scholar62. MackeyMcCulloughConlonShepardDeterlingCallow WJTARA. The costs of surgery for limb-threatening ischemia. Surgery. 1986;99:26-34. MedlineGoogle Scholar63. Orlando R. Continuous mixed venous oximetry in critically ill surgical patients. "High-tech" cost-effectiveness. Arch Surg. 1986;121:470-1. CrossrefMedlineGoogle Scholar64. OsterHuseDeleaColditz GDTG. Cost-effectiveness of nicotine gum as a adjunct to physician's advice against cigarette smoking. JAMA. 1986;256:1315-8. CrossrefMedlineGoogle Scholar65. Schoenberger J. Mild hypertension: the rationale for treatment. Am Heart J. 1986;112:872-6. CrossrefMedlineGoogle Scholar66. SniderCarasKoplan DGJ. Preventive therapy with isoniazid. Cost-effectiveness of different durations of therapy. JAMA. 1986:1579-83. CrossrefMedlineGoogle Scholar67. WeinerFraserBurnsSchnoorHerrigWhitaker CMJDJL. Cost efficacy of routine screening for diabetes in pregnancy: 1-h versus 2-h specimen. Diabetes Care. 1986;9:255-9. CrossrefMedlineGoogle Scholar68. BarryMulleyRichter MAJ. Effect of workup strategy on the cost-effectiveness of fecal occult blood screening for colorectal cancer. Gastroenterology. 1987;93:301-10. CrossrefMedlineGoogle Scholar69. BeckSalemEstesPauker JDNS. A computer-based Markov decision analysis of the management of symptomatic bifascicular block: the threshold probability for pacing. J Am Coll Cardiol. 1987;9:920-35. CrossrefMedlineGoogle Scholar70. BennionThompson RJ. Early appendectomy for perforated appendicitis in children should not be abandoned. Surg Gynecol Obstet. 1987:165:95-100. MedlineGoogle Scholar71. ClaibornePaynterDuttRowlands RDAJ. Evaluation of the use of an oxygen conservation device in long-term oxygen therapy. Am Rev Respir Dis. 1987;136:1095-8. CrossrefMedlineGoogle Scholar72. DevereuxCasaleWallersonKligfieldHammongLiebson RPDPIP. Cost-effectiveness of echocardiography and electrocardiography for detection of left ventricular hypertrophy in patients with systemic hypertension. Hypertension. 1987;9:1169-1176. CrossrefGoogle Scholar73. DittusRobertsAdolph RSR. Cost-effectiveness analysis of patient management alternatives after uncomplicated myocardial infarction: a model. J Am Coll Cardiol. 1987;10:869-78. CrossrefMedlineGoogle Scholar74. EddyNugentEddyCollerGilbertsenGottlieb DFJJVL. Screening for colorectal cancer in a high-risk population. Results of a mathematical model. Gastroenterology. 1987;92:682-92. CrossrefMedlineGoogle Scholar75. Erickson R. Impact of endoscopy on mortality from occult cancer in radiographically benign gastric ulcers. A probability analysis. Gastroenterology. 1987:93:835-45. CrossrefMedlineGoogle Scholar76. Evans R. The economics of heart transplantation. Circulation. 1987:75:63-76. CrossrefMedlineGoogle Scholar77. JasperMohsenifarKahanGoldbergKoerner AZSHS. Cost-benefit comparison of aerosol bronchodilator delivery methods in hospitalized patients. Chest. 1987:91:614-8. CrossrefMedlineGoogle Scholar78. JohnsonJolly MP. Analysis of a mass colorectal cancer screening program for cost-effectiveness. Am J Surg. 1987;154:261-3. CrossrefMedlineGoogle Scholar79. LaffelFinebergBraunwald GHE. A cost-effectiveness model for coronary thrombolysis/reperfusion therapy. J Am Coll Cardiol. 1987:10:79B-90B. CrossrefMedlineGoogle Scholar80. LeaStahlgren ML. Is resection appropriate for adenocardinoma of the pancreas? A cost-benefit analysis. Am J Surg. 1987;154:651-4. CrossrefMedlineGoogle Scholar81. MakiBotticelliLeRoyThielke DJMT. Prospective study of replacing administrative sets for intravenous therapy at 48- vs 72-hour intervals. 72 hours is safe and cost-effective. JAMA. 1987;258:1777-81. CrossrefMedlineGoogle Scholar82. NightingaleRobottiDeckersAllmendingerLoweLow CJPPRH. Quality care and cost-effectiveness. An organized approach to problem solving. Arch Surg. 1987;122:451-6. CrossrefMedlineGoogle Scholar83. OsterTudenColditz GRG. A cost-effectiveness analysis of prophylaxis against deep-vein thrombosis in major orthopedic surgery. JAMA. 1987:257:203-8. CrossrefMedlineGoogle Scholar84. OsterEpstein GA. Cost-effectiveness of antihyperlipemic therapy in the prevention of coronary heart disease. JAMA. 1987:258:2381-7. CrossrefMedlineGoogle Scholar85. SalzmanMcManamaShapiroRobertsonDonovanBlume EGALAH. Effect of optimization of hemodynamics on fibrinolytic activity and antithrombotic efficacy of external pneumatic calf compression. Ann Surg. 1987;206:636-41. CrossrefMedlineGoogle Scholar86. SpitalSpitalSpital RMA. The donor's decision in renal transplantation: a cost-benefit analysis. Am J Kidney Dis. 1987:9:396-403. CrossrefMedlineGoogle Scholar87. TiepCarterNicotraBerryPhillipsOtsap BRBJRB. Demand oxygen delivery during exercise. Chest. 1987;91:15-20. CrossrefMedlineGoogle Scholar88. WashingtonBrownerKorenbrot AWC. Cost-effectiveness of combined treatment for endocervical gonorrhea. Considering co-infection with Chlamydia trachomatis. JAMA. 1987;257:2056-60. CrossrefMedlineGoogle Scholar89. WarnerLuce KB. Cost-benefit and cost-effectiveness analysis in health care. Ann Arbor, Michigan: Health Administration Press; 1982. Google Scholar90. DrummondStoddardTorrance MGG. Methods for the Economic Evaluation of Health Care Programmes. New York: Oxford University Press; 1987. Google Scholar91. Fleiss J. Statistical Methods for Rates and Proportions. New York: John Wiley & Sons; 1981:212-36. Google Scholar92. DerSimonianCharetteMcPeekMosteller RLBF. Reporting on methods in clinical trials. N Engl J Med 1982;306:1332-1337. CrossrefMedlineGoogle Scholar93. Weller A. Editorial peer review in US medical journals. JAMA 1990:263(10):1344-1347. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Brigham and Women's Hospital, Harvard Medical School, and the Harvard School of Public Health, Boston, Massachusetts. For current author addresses, see end of text. 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