tbuckley/cabot-search huggingface dataset:
Body Dysmorphic Disorder: Treating an Underrecognized Disorder
Authors: Katharine A. Phillips, Elizabeth R. Didie, Jamie Feusner, Sabine Wilhelm
Journal: American Journal of Psychiatry (2008)

Mr. H," a 33-year-old single white male, presented with preoccupations focused on his "thinning" hair, facial "acne," and "short" fingers.He began to worry excessively about his appearance at age 15, focusing at that time on his "pale" skin and "uneven" cheekbones.Mr. H described his appearance preoccupations as "severely upsetting," but he was too embarrassed to reveal them to family or friends.Even though he looked normal to others, Mr. H was "100% convinced" that these body areas appeared "abnormal and deformed," although in the past he had sometimes thought that "maybe I don't look so bad."He believed that other people took special notice of him and "laugh at me behind my back because I look so ugly."Mr. H spent 5 to 6 hours a day thinking about his perceived appearance flaws.He also performed compulsive behaviors for 4 to 5 hours a day, which included excessive mirror checking, comparing his appearance with that of other people, wearing and frequently adjusting a baseball cap to cover his hair, picking his skin to remove tiny blemishes, and searching the Internet for acne and hair loss treatments.
IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis
Authors: Shiyu Wang, Zhouji Chen, Vivian Lam, Jaeseok Han, Justin Hassler, Brian N. Finck, Nicholas O. Davidson, Randal J. Kaufman
Journal: Cell Metabolism (2012)
Opiate Drugs and -Receptor-Mediated Myocardial Protection
Authors: P. E. Benedict, M. B. Benedict, T.-P. Su, S. F. Bolling
Journal: Circulation (1999)

Hypothermic myocardial arrest is necessary to complete most cardiac surgery, which limits the success of such operations. Similarly, cold, inhospitable environments limit the survival of warm-blooded animals. Animals have successfully adapted to this challenge through hibernation. Hibernation is an energy-conserving state, now known to be governed by cyclical variation in endogenous opiate compounds. It may also be induced in nonhibernators via hibernating animal serum factors or delta-opiate peptides. Furthermore, hibernation-induction triggers extend organ preservation in many models. This study examined whether opiate drugs with an affinity for the delta-opiate receptor confer similar protection.Isolated hearts harvested from New Zealand White rabbits were treated with either cardioplegia alone or delta-opiate drugs (fentanyl, morphine, buprenorphine, pentazocine) followed by 2 hours of 34 degrees C ischemia. Hearts were then reperfused, and functional and metabolic indices of treated groups were compared with untreated controls. Isovolumic developed pressure, coronary flow, and oxygen consumption were compared as a percent of preischemia versus 45 minutes after reflow. Developed pressure and oxygen consumption were better preserved in the morphine, buprenorphine, and pentazocine groups when compared with cardioplegia alone.Drugs with delta-opiate activity confer myocardial protection, which is additive to cardioplegia. Use of delta-opiate drugs in this context may have important clinical implications.
MESENCHYMAL STEM CELLS THERAPY IN PATIENTS WITH CHRONIC CORONARY ARTERY DISEASE: 12 MONTHS FOLLOW-UP
Authors: Jens Kastrup, Tina Friis, Mandana Haack-Sørensen, Anders B. Mathiasen, Rasmus S. Ripa, Ulrik S. Christoffersen, Erik Jørgensen, Birger Hesse, Andreas Kjær, Ebbe Dickmeiss
Journal: Journal of the American College of Cardiology (2011)
Reduced-intensity allogeneic transplantation in pediatric patients ineligible for myeloablative therapy: results of the Pediatric Blood and Marrow Transplant Consortium Study ONC0313
Authors: Michael A. Pulsipher, Kenneth M. Boucher, Donna Wall, Haydar Frangoul, Michel Duval, Rakesh K. Goyal, Peter J. Shaw, Ann E. Haight, Michael Grimley, Stephan A. Grupp, Morris Kletzel, Richard Kadota
Journal: Blood (2009)
The Cause of Follicular Spicules in Multiple Myeloma—Reply
Authors: Sander van Boheemen, Ron A. M. Fouchier, Enes Hajdarbegovic
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Guidelines, Online Training Aim to Teach Physicians to Weigh Costs of Care, Become Better Stewards of Medical Resources
Authors: Bridget M. Kuehn
Journal: JAMA (2014)

With health care spending now accounting for 18% of the US gross domestic product, physicians—like everyone else—are concerned about it, said Neel Shah, MD, executive director of Costs of Care, a nonprofit organization working "to deflate" medical bills.
Correlation of continuous wave doppler velocities with cardiac catheterization gradients: An experimental model of aortic stenosis
Authors: Mikel D. Smith, Philip L. Dawson, Jonathan L. Elion, David C. Booth, Rodney Handshoe, Oi Ling Kwan, Gary F. Earle, Anthony N. DeMaria
Journal: Journal of the American College of Cardiology (1985)
Reporting systems for cardiac surgery
Authors: Vipin Zamvar
Journal: BMJ (2004)

<h3>Background</h3> Stomach cancer is one of the most common malignancies and a primary cause of cancer death. It is a disease with an aggressive nature and a low survival rate, resulting in a significant cancer burden worldwide. Using global and national cancer registries, we investigated the most recent global incidence of stomach cancer by histological subtypes. <h3>Methods</h3> The WHO Cancer Incidence in Five Continents and Global Cancer Observatory were used to assess the incidence of stomach cancer by histological subtypes in 2020. The world standard population was used to estimate age-standardised rates for stomach cancer incidence by histological subtypes. <h3>Results</h3> In 2020, the global stomach cancer incidence was estimated to be 11.1 per 100 000 persons with 1089103 cases. The global cardia stomach cancer incidence was 2.0, with higher incidence observed in the male population (3.2 vs. 0.91 in females); Eastern Asia (4.5), Western Asia (1.6), Western Europe (1.6), and Oceania (1.6); and countries with high HDI (3.2 vs. 0.32 for low HDI countries). The global non-cardia stomach cancer incidence was 9.1, with higher incidence observed in the male population (12.6 vs. 6.1 in females); Eastern Asia (17.9), Central and Eastern Europe (10.2), South America (8.1), and Western Asia (6.9); and countries with high HDI (11.5 vs. 4.2 for low HDI countries). <h3>Conclusions</h3> In Eastern Asia, Central and Eastern Europe, and South America, non-cardia stomach cancer remains the most common subtype of stomach cancer. Eastern Asia, Western Asia, and Western Europe had the greatest rates of cardia stomach cancer. The reasons for the variations in stomach cancer distribution by histological subtypes need to be investigated further.
Endoscopic ultrasound-guided drainage of abdominal abscesses and infected necrosis
Authors: S. Seewald, T. Ang, K. Teng, S. Groth, Y. Zhong, H. Richter, H. Imazu, S. Omar, L. Polese, U. Seitz, P. Bertschinger, J. Altorfer, N. Soehendra
Journal: Endoscopy (2009)

Traditionally abdominal abscesses have been treated with either surgical or radiologically guided percutaneous drainage. Surgical drainage procedures may be associated with considerable morbidity and mortality, and serious complications may also arise from percutaneous drainage. Endoscopic ultrasound (EUS)-guided drainage of well-demarcated abdominal abscesses, with adjunctive endoscopic debridement in the presence of solid necrotic debris, has been shown to be feasible and safe. This multicenter review summarizes the current status of the EUS-guided approach, describes the available and emerging techniques, and highlights the indications, limitations, and safety issues.
Large granular lymphocyte leukemia with pure red cell aplasia in a renal transplant recipient
Authors: Michihiko Masuda, Yukari Arai, Hiroyuki Nishina, Shouhei Fuchinoue, Hideaki Mizoguchi
Journal: American Journal of Hematology (1998)

Neoplastic disorders sometimes accompany a renal transplant. Herein, we report a large granular lymphocyte (LGL) leukemia patient with pure red cell aplasia (PRCA) after renal transplantation. A 36-year-old female was presented to our department with anemia in February 1996. She had undergone hemodialysis because of pregnancy in December 1981. She received a renal transplantation from her mother in April 1986. After the transplantation, she received cyclosporin A (CyA) at 2 mg/kg/day, mizoribine at 1 mg/kg/day, and methylprednisolone at 0.1 mg/kg/day for 8 years. In July 1995, her hemoglobin level dropped to 9.3 g/dl, and anemia developed gradually. In January 1996, her hemoglobin was 5.8 g/dl, and she was given a red blood cell transfusion. Laboratory findings were as follows: RBC 1.46 × 1012/L; hemoglobin 5.8 g/dl; hematocrit 17.8%; leucocytes 5.2 × 109/L with 62.4% neutrophils, 34.1% lymphocytes, 2.6% monocytes; platelets 50.8 × 1010/L; reticulocytes 0.4%. Bone marrow aspirate smears and biopsy sections revealed normal myeloid and megakaryocyte differentiation with few erythroid precursors. The lymphocytes were of medium size with granules in the cytoplasm. More than 90% of lymphocytes were of the LGL type. Surface markers of peripheral blood mononuclear cells demonstrated increases in the CD2+, CD3+, CD4−, and CD8+ populations. A monoclonal rearrangement of T-cell receptor (TCR)-β chain gene was found by Southern blot analysis of the mononuclear cells in peripheral blood. A diagnosis of LGL leukemia with PRCA was made. During the next 4 months, she received six red blood cell transfusions, a total of 12 U. In March 1996, the patient was treated with cyclophosphamide (1 mg/kg/day). After 1 month of treatment, serum GPT levels increased to 60 IU/l. The dose of cyclophosphamide was reduced to 0.5 mg/kg/day. Two months after initiation of the therapy, the patient developed reticulocytosis and blood transfusion was not needed thereafter. During remission, the number of CD2+, CD3+, CD4−, and CD8+ lymphocytes decreased. Large granular lymphocytes decreased to less than 10% of peripheral blood. The monoclonal rearrangement of the TCR-β chain gene in peripheral blood disappeared. Am. J. Hematol. 57:72–76, 1998. © 1998 Wiley-Liss, Inc.
Outcome of 122 pregnancies in essential thrombocythemia patients: A report from the Italian registry
Authors: Lorella Melillo, Alessia Tieghi, Anna Candoni, Franca Radaelli, Rosanna Ciancia, Giorgina Specchia, Bruno Martino, Potito Rosario Scalzulli, Roberto Latagliata, Fausto Palmieri, Emilio Usala, Daniela Valente, Maria Rosa Valvano, Michele Cedrone, Giuseppina Comitini, Vincenzo Martinelli, Nicola Cascavilla, Luigi Gugliotta
Journal: American Journal of Hematology (2009)

Pregnancy is a high-risk event in women with essential thrombocythemia (ET). This observational study evaluated pregnancy outcome in ET patients focusing on the potential impact of aspirin (ASA) or interferon alpha (IFN) treatment during pregnancy. We retrospectively analyzed 122 pregnancies in 92 women consecutively observed in the last 10 years in 17 centers of the Italian thrombocythemia registry (RIT). The live birth rate was 75.4% (92/122 pregnancies). The risk of spontaneous abortion was 2.5-fold higher than in the control population (P < 0.01). ASA did not affect the live birth rate (71/93, 76.3% vs. 21/29, 72.4%, P = 0.67). However, IFN treatment during pregnancy was associated with a better outcome than was management without IFN (live births 19/20, 95% vs. 73/102, 71.6%, P = 0.025), and this finding was supported by multivariate analysis (OR: 0.10; 95% CI: 0.013-0.846, P = 0.034). The JAK2 V617F mutation was associated with a poorer outcome (fetal losses JAK2 V617F positive 9/25, 36% vs. wild type 2/24, 8.3%, P = 0.037), and this association was still significant after multivariate analysis (OR: 6.19; 95% CI: 1.17-32.61; P = 0.038). No outcome concordance between first and second pregnancies was found (P = 0.30). Maternal complications occurred in 8% of cases. In this retrospective study, in consecutively observed pregnant ET patients, IFN treatment was associated with a higher live birth rate, while ASA treatment was not. In addition, the JAK2 V617F mutation was confirmed to be an adverse prognostic factor.
Role of the major histocompatibility gene products in regulating the antibody response to dinitrophenylated poly(L-Glu55,L-Ala35,L-Phe9)n.
Authors: S K Pierce, N R Klinman, P H Maurer, C F Merryman
Journal: The Journal of Experimental Medicine (1980)

These studies were carried out to investigate the potential helper T cell repertoire specific for the random copolymer poly(L-Glu55,L-Ala35, L-Phe9)n(GL phi 9) of responder, nonresponder, and (responder x nonresponder)F1 murine strains. We tested the ability of these T cells to collaborate with dinitrophenyl (DNP)-specific primary and secondary B lymphocytes of each strain in response to the antigen CNP-GL phi 9 in the splenic-fragment culture system. The results of these experiments show that there are GL phi 9-specific T lymphocytes in the responder, nonresponder, and F1 strains; but that these three GL phi 9-specific T cell populations differ in their collaborative potential. Responder T cells are able to collaborate with their own syngeneic responder B cells as well as the allogeneic nonresponder B cells in a syngeneic fashion. The F1 T cell population resembles that of the nonresponder in its ability to collaborate with only responder B cells in a syngeneic fashion. Analysis carried out using appropriately selected mouse strains indicate that these results are unlikely to be a result of positive or negative allogeneic effects. The results obtained suggest that individuals within a given murine strain do possess the capacity to collaborate in a syngeneic fashion with B cells of any other MHC-allogeneic strain as well as their own MHC-identical B cells. The nonresponder status in the response to GL phi 9 appears to be the result of a deletion of T cells capable of recognizing antigen in the context of B cells of the nonresponder haplotype. Thus, the MHC gene products appear to play a determinative role in shaping the expressed helper T cell specificity repertoire within an individual mouse strain.
Diabetes and Diabetic Retinopathy in a Mexican-American Population
Authors: Sheila K. West, Ronald Klein, Jorge Rodriguez, Beatriz Muñoz, Aimee T. Broman, Rosario Sanchez, Robert Snyder
Journal: Diabetes Care (2001)

OBJECTIVES The prevalence rate of diabetes is probably higher in Hispanics than in Caucasians, although there is controversy about differences in the risk of diabetic retinopathy. The purpose of the study is to determine the prevalence rates of diabetes and diabetic retinopathy in a population-based study of Hispanics aged ≥40 years. RESEARCH DESIGN AND METHODS—Proyecto VER is a random sample of Hispanic populations aged ≥40 years in Arizona. A total of 4,774 individuals (71.6% of the eligible sample) completed the examinations. Diabetes was defined as self-report of a physician diagnosis or HbA1c value of ≥7.0%. Diabetic retinopathy was assessed on stereo fundus photographs of fields 1, 2, and 4. RESULTS—The prevalence rate of diabetes in the Hispanic community (individuals ≥40 years of age) was 22%. The prevalence rate of diabetic retinopathy (DR) was 48%; 32% had moderate to severe nonproliferative and proliferative retinopathy. DR increased with increasing duration of diabetes and increasing level of HbA1c. The prevalence rate of DR-like changes in the sample of individuals without diabetic retinopathy was 15% and was not associated with hypertension, systolic blood pressure, or diastolic blood pressure. CONCLUSIONS—The prevalence rate of diabetes in this population of Hispanics is high, almost twice that of Caucasians. The prevalence rate of DR is high but similar to reports in a Caucasian population. The prevalence rate of 9% moderate to severe retinopathy in the newly diagnosed group suggests that efforts to improve detection and treatment of diabetes in Hispanics may be warranted.
Use of Terfenadine and Contraindicated Drugs
Authors: David Thompson
Journal: JAMA (1996)

To assess changes in concurrent use of products containing terfenadine and contraindicated macrolide antibiotics (erythromycin, clarithromycin, troleandomycin) and imidazole antifungals (ketoconazole, itraconazole) following reports of serious drug-drug interactions and changes in product labeling.Retrospective review of computerized pharmacy claims.A large health insurer in New England.Health plan members with 1 or more paid pharmacy claims for products containing terfenadine between January 1990 and June 1994.Among persons with paid claims for terfenadine in any given month, percentage with a prescription for any contraindicated drug that alternatively was dispensed on the same day as ("same-day dispensing") or had therapy days that overlapped those of ("overlapping use") a prescription for terfenadine.Concurrent use of terfenadine and contraindicated drugs declined over the study period. The rate of same-day dispensing declined by 84% from an average of 2.5 per 100 persons receiving terfenadine in 1990 to 0.4 per 100 persons during the first 6 months of 1994, while the rate of overlapping use declined by 57% (from 5.4 to 2.3 per 100 persons). Most cases involved erythromycin.Despite substantial declines following reports of serious drug-drug interactions and changes in product labeling, concurrent use of terfenadine and contraindicated macrolide antibiotics and imidazole antifungals continues to occur.
Additional Evidence for High-Resistance Inter-calated Discs in the Myocardium
Authors: NICK SPERELAKIS, John Egna
Journal: Circulation Research (1963)

Parallel-fibered strips of cardiac (cat papillary) and skeletal (frog sartorius) muscles were mounted in air and action potentials were externally recorded from the middle of the strip. Electric fields, oriented longitudinally with respect to the long axis of the cells, were applied. A pair of stimulating electrodes was located at each end of the strip to test for propagation. Under conditions of blocked propagation produced by addition of isotonic sucrose solution, the cells near the middle of the strip could be tested for direct response to longitudinal fields. In long-celled skeletal muscle, the sucrose solution produced simultaneously failure of electrical and mechanical response to stimulation across the strip as well as failure of propagation; stimulation at ten times threshold failed to elicit responses. However, in short-celled cardiac muscle, the sucrose solution produced failure of propagation first; electrical and mechanical responses to longitudinal field stimulation continued without a change in threshold. From these experiments it may be concluded that transverse membranes of high resistance are present in cardiac muscle; thus, radial currents are forced to flow through each cell membrane leading to direct excitation.
Can more efficient use be made of x ray examinations in the accident and emergency department?
Authors: D N Gleadhill, J Y Thomson, P Simms
Journal: BMJ (1987)

Increasing workloads in our radiology department prompted a study of casualty officers' use of x ray examinations, of which there were 5463 in the period. While casualty officers were in post referrals for x ray examination did not become more selective, but skills in interpreting films improved. Overall, 4.9% of trauma radiographs were misinterpreted, but this fell from 7.1% to 2.9% during tenure of post. One in four errors was clinically important. Clinical guidelines for selective radiography produced a significant and sustained reduction in the number of x ray examinations requested by the department. Analysis of one common injury indicated that the quality of patient care was not adversely affected. The number of x ray examinations carried out in the accident and emergency department can be reduced by using guidelines, and this does not compromise the quality of patient care. Appreciable savings may be made in patients' waiting times and radiodiagnostic expenditure.
Transcervical Balloon Tuboplasty (and Which End Is Distal?)
Authors: Ferris M. Hall
Journal: JAMA (1991)

To the Editor.—  I commend Confino et al1on their therapeutic use of balloon tuboplasty for obstructed fallopian tubes, and particularly on their emphasis on pregnancy rather than tube patency in assessing the success of the procedure.  The authors point out that proximal tubal occlusion is frequently caused by an intraluminal plug rather than an intrinsic disorder of the fallopian tube itself. Tuboplasty seems ideally suited to such cases, whereas microsurgical tubal reanastomosis would convert an apparently normal tube into a scarred oviduct. The article demonstrates that tubal recanalization by balloon tuboplasty is frequently successful. However, it does not answer the more important question of whether balloon dilation is preferable to the simpler and probably safer tuboplasty by means of only a guide wire, or wire and catheter. The latter techniques are currently used by hundreds of physicians. They have a very good track record and are more economical