Prevention of NSAID-induced Gastric Ulcer
Authors: Ronald L. Koretz
Journal: Annals of Internal Medicine (1991)

Letters1 December 1991Prevention of NSAID-induced Gastric UlcerRonald L. Koretz, MDRonald L. Koretz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-11-911 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Agrawal and coworkers (1) described a prospective, randomized controlled trial comparing sucralfate and misoprostol in the treatment of patients with nonulcer pain associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). They observed that patients treated with misoprostol had a five- to ten-fold decrease in the incidence of subsequent gastric ulceration. The implication is that misoprostol is the preferred agent.The development of a gastric ulcer was the primary end point of the study. The occurrence of any serious complications (for example, hemorrhage or perforation) of ulcer disease was not reported. Other observations indicated a greater percentage...Reference1. AgrawalRothGrahamWhiteGermainBrown NSDRBJ. Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer. A randomized controlled trial. Ann Intern Med. 1991;115:195-200. LinkGoogle Scholar1. AgrawalRothGrahamWhiteGermainBrown NSDRBJ. Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer. A randomized controlled trial. Ann Intern Med. 1991;115:195-200. LinkGoogle Scholar2. Soll A. Pathogenesis of peptic ulcer and implications for therapy. N Engl J Med. 1990;322:913-4. Google Scholar3. SollKvrataMcGuigan AJJ. Ulcers, nonsteroidal anti-inflammatory drugs and related matters. Gastroenterology. 1989;96:568. CrossrefGoogle Scholar1. AgrawalRothGrahamWhiteGermainBrown NSDRBJ. Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer. A randomized controlled trial. Ann Intern Med. 1991;115:195-200. LinkGoogle Scholar2. Soll A. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann Intern Med. 1991;114:307-19. LinkGoogle Scholar3. LanzaRoyerNelson FGR. Endoscopic evaluation of the effects of aspirin, buffered aspirin, and enteric-coated aspirin on gastric and duodenal mucosa. N Engl J Med. 1980;303:136-8. CrossrefMedlineGoogle Scholar4. SilvosoIveyButtLockardHoltSisk GKJOSC. Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy. Ann Intern Med. 1979;91:517-20. LinkGoogle Scholar5. BrooksDay PR. Nonsteroidal anti-inflammatory drugs-differences and similarities. N Engl J Med. 1991;324:1716-25. CrossrefMedlineGoogle Scholar1. AgrawalRothGrahamWhiteGermainBrown NSDRBJ. Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer. A randomized controlled trial. Annals Intern Med. 1991;115:195-200. LinkGoogle Scholar2. AgrawalPatelMahatmaDajani NRME. Nonsteroidal antiinflammatory drugs and acute upper gastrointestinal bleeding: A prospective study. J Am Acad Min Phys. 1991;2:64-6. MedlineGoogle Scholar3. FDC reports. Chevy Chase, Maryland. 30 November 1988. Google Scholar4. GrahamAgrawalRoth DNS. Prevention of NSAID-induced gastric ulcer with the synthetic prostaglandin, misoprostol. A multicenter, double-blind, placebo-controlled trial. Lancet. 1988;2:1277-80. CrossrefMedlineGoogle Scholar5. GrahamStromattJaszewski DSR. Prevention of duodenal ulcer in arthritics who are chronic NSAID users: a multicenter trial of the role of misoprostol. Gastroenterology. 1991;100:A75. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Olive View Medical Center Sylmar, CA 91342 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBeta-Agonists in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease 1 December 1991Volume 115, Issue 11Page: 911-913KeywordsDrugsGastric ulcersHemorrhageNSAIDsPatientsUlcers Issue Published: 1 December 1991 PDF downloadLoading ...