FURTHER OBSERVATIONS ON THE TREATMENT OF PERNICIOUS ANEMIA WITH PARENTERAL HORSE LIVER EXTRACT*
Authors: OSCAR RICHTER
Journal: Annals of Internal Medicine (1933)

Article1 September 1933FURTHER OBSERVATIONS ON THE TREATMENT OF PERNICIOUS ANEMIA WITH PARENTERAL HORSE LIVER EXTRACTINCLUDING ONE CASE OF PERNICIOUS ANEMIA FOLLOWING GASTRECTOMYOSCAR RICHTER, M.D., ARTHUR E. MEYER, PH.D., ANDREW C. IVY, M.D., PH.D., F.A.C.P.OSCAR RICHTER, M.D.Search for more papers by this author, ARTHUR E. MEYER, PH.D.Search for more papers by this author, ANDREW C. IVY, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-3-353 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently we1have reported that excellent remissions can be obtained in pernicious anemia patients with low blood counts from the subcutaneous or intravenous injections of a potent, highly purified horse liver extract. This communication entails a report of our observations on the further use of this injectable liver extract in 46 patients with pernicious anemia, covering a period of one year, during which time several thousand injections were given without local or systemic reaction. Although the oral administration of whole liver, liver extracts, and stomach substance are of unquestionable value in the treatment and maintenance of patients with pernicious anemia,...Bibliography1. MEYERRICHTERIVY AEOAC: The treatment of pernicious anemia with equine liver extract injectable either subcutaneously or intravenously, Arch. Int. Med., 1932, 1, 538-543. CrossrefGoogle Scholar2. COHNMCMEEKINMINOT EJTLGR: The nature of the material effective in pernicious anemia, Am. Jr. Physiol., 1929, xc, 316-317. Google Scholar3. GANSSLEN M: Ein wirksamer, injizierbarer Leberextrakt, Verhandl. d. deutsch. Gesellsch. f. inn. Med., Kong., 42, 1930, p. 524. Google Scholar4. CASTLETAYLOR WBFH: Intravenous use of extract of liver; maximal responses of reticulocytes from single injection derived from 100 grams of liver; preliminary communication, Jr. Am. Med. Assoc., 1931, xcvi, 1198-1201. CrossrefGoogle Scholar5. STRAUSSTAYLORCASTLE MBFHWB: Intramuscular use of liver extract; maximal responses of reticulocytes from daily intramuscular injection of extract derived from 10 grams of liver; preliminary communication, Jr. Am. Med. Assoc., 1931, xcvii, 313-314. CrossrefGoogle Scholar6. AUBERTINVOILLEMIN C: Anémie pernicieuse traitée par des injections intramusculaires d'extrait hépatique, Bull. et mém. Soc. méd. d. hôp. de Paris, 1930, liv, 749-751. Google Scholar7. ACHARDHAMBURGER CM: L'opothérapie hépatique par voie parentérale dans le traitement des anémies graves, Presse méd., 1930, xxxviii, 1273-1274. Google Scholar8. VAN LEEUWEN HC: Treatment of pernicious anemia by intravenous administration of liver extract, Nederl. tijdschr. v. geneesk., 1931, lxxv, 4425-4433. Google Scholar9. SELANDER P: Injectable liver preparation, Hygeia, 1931, xciii, 625-629. Google Scholar10. HARRINGTONFLEMING AWJ: Treatment of pernicious anemia by injections of liver extract, Glasgow Med. Jr., 1931, cxvi, 345-351. Google Scholar11. MURPHY WP: The parenteral use of liver extract in pernicious anemia, Jr. Am. Med. Assoc., 1932, xcviii, 1051-1060. CrossrefGoogle Scholar12. STRAUSSCASTLE MBWB: Parenteral liver therapy in the treatment of pernicious anemia, Jr. Am. Med. Assoc., 1932, xcviii, 1620-1623. CrossrefGoogle Scholar13. RICHTERMEYERIVY OAEAC: Treatment of pernicious anemia with horse liver extract; preliminary report, Jr. Am. Med. Assoc., 1932, xcviii, 1623-1625. CrossrefGoogle Scholar14. SINGER HA: Syphilis of the stomach with special reference to its relationship to linitis plastica, Am. Jr. Syph., 1929, xiii, 391-410. Google Scholar15. CASTLEHEATHSTRAUSSTOWNSEND WBCWMBWC: The relationship of disorders of the digestive tract to anemia, Jr. Am. Med. Assoc., 1931, xcvii, 904-907. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: OSCAR RICHTER, M.D.; ARTHUR E. MEYER, PH.D.; ANDREW C. IVY, M.D., PH.D., F.A.C.P.Affiliations: Chicago, Illinois*Received for publication November 11, 1932.This work was made possible by a grant from the Chappel Foundation for Organotherapeutic Research and was done at Northwestern University and Cook County Hospital. Technician, Miss Helen Legere. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMEGALOBLASTIC AND TRANSITIONAL MEGALOBLASTIC ANAEMIA FOLLOWING PARTIAL GASTRECTOMYDie Erkrankungen des erythrocytären SystemsErkennung und Behandlung der Anämien 1 September 1933Volume 7, Issue 3Page: 353-368KeywordsBlood countsIntravenous injectionsLiverOral administrationPernicious anemiaStomachSubcutaneous injectionsTechnicians ePublished: 1 December 2008 Issue Published: 1 September 1933 PDF downloadLoading ...