tbuckley/cabot-search huggingface dataset:
Idiopathic Cold Urticaria: In Vitro Demonstration of Histamine Release upon Challenge of Skin Biopsies
Authors: Allen P. Kaplan, John Garofalo, Robert Sigler, Theresa Hauber
Journal: New England Journal of Medicine (1981)

WHEN patients with cold-induced urticaria are challenged with a cold stimulus, their exposed areas become pruritic, and hive formation and swelling are evident within a few minutes.1 Investigations regarding the pathogenesis of idiopathic cold urticaria have revealed a number of critical features of the reaction. In virtually all cases studied, histamine1 , 2 and other granule-associated chemotactic factors3 , 4 were released into the circulation when the patient was challenged by having one hand placed in ice water. The sensitivity to cold in some patients (10 per cent in our series) can be passively transferred,5 and this activity can be selectively removed with an . . .
Gamma glutamyl transpeptidase expression in foetal skin, inflammatory dermatoses and cutaneous neoplasia
Authors: R. W. GROVES, J. N. FRACCHIA, D. M. MACDONALD
Journal: British Journal of Dermatology (1991)

Gamma glutamyl transpeptidase (GGT) is an enzyme expressed by some epithelial neoplasms but not normal interfollicular epidermis. In order to examine the relationship between malignant change and de-differentiation we studied histochemically the expression of GGT in human foetal skin, various inflammatory dermatoses and epidermal neoplasms. In foetal skin GGT was detectable after 7 weeks' gestation, reached a maximum at 11 weeks and was undetectable by 24 weeks. It was expressed strongly by squamous cell carcinoma and focally in Bowen's disease and actinic keratoses. There was no GGT expression in basal cell carcinoma or most benign skin tumours, but keratoacanthomas were weakly positive. Keratinocytes in the vicinity of malignant melanocytes also expressed GGT. This study suggests that GGT expression, while not a simple marker of malignancy, may represent reversion to a less differentiated or 'foetal' phenotype.
Effectiveness of health checks conducted by nurses in primary care: results of the OXCHECK study after one year
Authors: J Muir, D Mant, L Jones, P Yudkin
Journal: BMJ (1994)

Objective : To assess the effectiveness of health checks by nurses in reducing risk factors for cardiovascular disease in patients from general practice. Design : Randomised controlled trial. Setting : Five urban general practices in Bedfordshire. Subjects : 2136 patients receiving an initial health check in 1989-91 and scheduled to be re-examined one year later in 1990-2 (intervention group); 3988 patients receiving an initial health check in 1990-2 (control group). All patients were aged 35-64 years at recruitment in 1989. Main outcome measures : Serum total cholesterol concentration, blood pressure, body mass index, confirmed smoking cessation. Results : Mean serum total cholesterol was 2.3% lower in the intervention group than in the controls (difference 0.14 mmol/l (95% confidence interval 0.08 to 0.20)); the difference was greater in women (3.2%, P<0.0001) than men (1.0%, P=0.18). There was no significant difference in smoking prevalence, quit rates, or body mass index. Systolic and diastolic blood pressure were 2.5% and 2.4% lower respectively in the intervention group. The proportion of patients with diastolic blood pressure >=100 mm Hg was 2.6% (55/2131) in the intervention group and 3.4% (137/3987) in the controls (difference 0.9% (0.0 to 1.7); the proportion with total cholesterol concentration >=8 mmol/l 4.8% (100/2068) and 7.6% (295/3905) (difference 2.7% (1.5 to 4.0)); and that with body mass index >=30 12.4% (264/2125) and 14.0% (559/3984) (difference 1.6% (-0.2 to 3.4)). Conclusion : General health checks by nurses are ineffective in helping smokers to stop smoking, but they help patients to modify their diet and total cholesterol concentration. The public health importance of this dietary change depends on whether it is sustained.
Persistent BK Viremia Does Not Increase Intermediate-Term Graft Loss but Is Associated with De Novo Donor-Specific Antibodies
Authors: Deirdre Sawinski, Kimberly A. Forde, Jennifer Trofe-Clark, Priyanka Patel, Beatriz Olivera, Simin Goral, Roy D. Bloom
Journal: Journal of the American Society of Nephrology (2014)

There are limited data regarding intermediate-term outcomes in patients with persistent BK viremia. Other viral infections have been implicated in the development of allosensitization through heterologous immunity, but the relationship between BK viremia and donor-specific antibodies (DSAs) is unexplored. In 2008, we initiated routine post-transplant BK viremia and DSA screening at our center; 785 kidney or kidney–pancreas transplant recipients were included in our study. Of these recipients, 132 (17%) recipients developed BK viremia during the study period. The median duration of BK viremia was 140 days (interquartile range=40–393 days), and persistent BK viremia was defined as lasting ≥140 days. Kaplan–Meier curves were generated to assess differences in patient and allograft survival on the basis of BK viremia status; survival was modeled using Cox proportional hazard regression. After a median follow-up of 3 years, there was no significant difference in terms of patient (hazard ratio [HR], 0.83; 95% confidence interval [95% CI], 0.28 to 2.49) or allograft survival (HR, 0.80; 95% CI, 0.37 to 1.73) between patients with and without BK viremia, which was confirmed in a time-varying analysis. In our logistic regression model, persistent BK viremia was strongly associated with the development of class II (HR, 2.55; 95% CI, 1.30 to 4.98) but not class I (HR, 1.13; 95% CI, 0.46 to 2.77) DSAs. These data suggest that persistent BK viremia does not negatively affect intermediate-term patient or allograft survival but is associated with increased risk for de novo DSA, although the exact mechanism is unclear.
Microscopic 3D-CT imaging after catheter–based channel creation in normal porcine myocardium and histologic comparison with ischemic human myocardium previously treated with surgical transmyocardial revascularization
Authors: C.J. McKenna, H.M. Kwon, G. Sangiorgi, L. Ellis, R. AuBuchon, P.J. Carlson, E.L Ritman, D.R. Holmes, R. Virmani, R.S. Schwartz
Journal: Journal of the American College of Cardiology (1998)
Delineation of four cell types comprising the giant cell tumor of bone. Expression of Ia and monocyte-macrophage lineage antigens.
Authors: G R Burmester, R J Winchester, A Dimitriu-Bona, M Klein, G Steiner, H A Sissons
Journal: Journal of Clinical Investigation (1983)

Giant cell tumors of bone dissociated by collagenase digestion were found to be composed of four different cell types defined by morphology, growth in culture, and pattern of staining with monoclonal antibodies. Giant cells comprised an average of 0.8% of the cells recovered, with the remainder consisting of small stromal cells. Of the giant cells, 20-57% expressed Ia antigens, while all lacked IgG Fc receptors and five differentiation antigens associated with mature members of the monocyte-macrophage lineage (M phi S-1, M phi P-9, M phi P-15, M phi S-39, and 63d3). One antigen, M phi U-50, found on early monocytoid forms was expressed on Ia+ giant cells. 6-36% of the remaining stromal tumor cells formed a second subpopulation that assumed either a rounded or elongated shape in culture. These cells bore Ia antigens, IgG Fc receptors, and five antigens of the monocyte-macrophage lineage usually found on blood monocytes. However, these cells differed from monocytes or macrophages in that the antigen M phi R-17 generally found on tissue macrophages was absent, and the M phi U-50 antigen present on more primitive cells was well expressed. A very limited endocytic capacity was demonstrable. A third population of up to 24% of the tumor cells was defined by the presence of intense staining for Ia antigens but the absence of antigens of mature monocytes. A proportion of these cells expressed M phi U-50 and a minority had IgG Fc receptors. The two Ia(+) populations of stromal cells were not identifiable after 2 wk of culture, nor did tumor cells selected for the presence of Ia antigens proliferate in culture. A fourth population of cells lacked Ia and monocyte lineage antigens, but showed pronounced intracellular staining for acid phosphatase. These cells had a distinctive plump epitheloid to fibroblastoid morphology and were readily established in long-term culture where they gave rise to large multinuclear Ia(-) cells containing acid phosphatase. The possibility is discussed that the cell types of these tumors relate to various stages in the development of osteoclasts from precursors in the mononuclear phagocyte lineage.
Inhibition of postprandial pancreatic and biliary secretion by loperamide in patients with short bowel syndrome.
Authors: M Remington, C R Fleming, J R Malagelada
Journal: Gut (1982)

Patients with the short bowel syndrome are usually afflicted by chronic diarrhoea and treated with opiate drugs, yet little documentation of the effects of such drugs on digestive function is available. In the present study we found that acute oral administration of loperamide resulted in 50% inhibition of postprandial trypsin and bilirubin output in patients with short bowel syndrome. These changes are consistent with an opiate effect.
A VOLSELLUM FORCEPS WITH DETACHABLE HANDLES
Authors: A. HERZFELD
Journal: JAMA (1910)

Occasions frequently arise when curettage, or in fact any vaginal operative interference on the uterus, has to be done without sufficient assistance. In many cases for better orientation the grasping of the uterus has to be done through a bivalve speculum. It is very difficult, if not impossible to remove the bivalve speculum after the uterus is grasped with the ordinary volsellum forceps on account of the width of the handles of the instrument. To facilitate the removal of the speculum, I devised a volsellum forceps with detachable handles. The handles are easily applied and removed by means of a bayonet lock. 224 West Twenty-Fourth Street.
Sam Pullar Smith
Authors: D. Anderson
Journal: BMJ (2003)

Former consultant radiologist Hull Royal Infirmary (b 1926; q Glasgow 1950; MD, DMRD), died from a brain tumour on 23 January 2003.

Sam did his house jobs at the Victoria and Royal Infirmaries in Glasgow before serving in the Royal Air Force. After a brief spell in general practice he started radiology training in Glasgow, going on to be senior registrar at Dundee. He took up his first consultant appointment in Rotherham in 1963, moving to lead the department in Hull in 1965. In 1986 he retired to Burford, where he served on the town council. He was a keen dog lover and fly fisher. He leaves a wife, Margaret Anne.
Absence of endogenous interleukin 10 enhances early stress response during post-ischaemic injury in mice intestine
Authors: B Zingarelli, Z Yang, P W Hake, A Denenberg, H R Wong
Journal: Gut (2001)

BACKGROUND Interleukin 10 (IL-10) exerts a wide spectrum of regulatory activities in immune and inflammatory responses. AIMS The aim of this study was to investigate the role of endogenous IL-10 on modulation of the early inflammatory response after splanchnic ischaemia and reperfusion. METHODS Intestinal damage was induced by clamping the superior mesenteric artery and the coeliac trunk for 45 minutes followed by reperfusion in IL-10 deficient mice (IL-10 −/− ) and wild-type controls. RESULTS IL-10 −/− mice experienced a higher rate of mortality and more severe tissue injury compared with wild-type mice subjected to ischaemia and reperfusion. Splanchnic injury was characterised by massive epithelial haemorrhagic necrosis, upregulation of P-selectin and intercellular adhesion molecule 1, and neutrophil infiltration. The degree of oxidative and nitrosative damage was significantly higher in IL-10 −/− mice than in wild-type littermates, as indicated by elevated malondialdehyde levels and formation of nitrotyrosine. Plasma levels of the proinflammatory cytokines tumour necrosis factor α and interleukin 6 were also greatly enhanced in comparison with wild-type mice. These events were preceded by increased immunostaining and activity of the stress regulated c-Jun NH 2 terminal kinase and activation of the transcription factor activator protein 1 in the cellular nuclei of damaged tissue. CONCLUSIONS These data demonstrate that endogenous IL-10 exerts an anti-inflammatory role during reperfusion injury, possibly by regulating early stress related genetic response, adhesion molecule expression, neutrophil recruitment, and subsequent cytokine and oxidant generation.
p53 protein expression in benign and malignant skin tumours
Authors: Y.S. RO, P.N. COOPER, J.A. LEE, A.G. Quinn, D. HARRISON, D. LANE, C.H.W. HORNH, J.L. REES, B. ANGUS
Journal: British Journal of Dermatology (1993)

The skiu affords an excellent model of human carcinogenesis because a variety of lesions from benign tumours to invasive malignancy, with or without metastatic potential, are commonly found, and are accessible to biopsy. To date, few genetic alterations have been observed in skin neoplasia. In this study we have used a recently developed monoclonal antibody (DO7) to examine p53 protein expression in a wide variety of benign and malignant skin lesions. Benign skin lesions were negative, but a significant number of malignant epithelial lesions showed detectable p53: 56% of squamous carcinomas and 42% of basal cell carcinomas were positive. A smaller proportion of dysplastic epithelial lesions were positive (27%). and only 3.6% of malignant melanomas were positive. Thus, although detectable p53 protein is a common occurrence in malignant epithelial lesions, it does not correlate with the malignant phenotype or with metastatic potential. The finding of a lower proportion of positivity in dysplastic lesions. and absence of staining in benign tumours, suggests that p53 mutation may be involved in the progression towards invasive malignancy in human squamous skin lesions.
Macular Morphology and Visual Acuity in the Comparison of Age-related Macular Degeneration Treatments Trials
Authors: Glenn J. Jaffe, Daniel F. Martin, Cynthia A. Toth, Ebenezer Daniel, Maureen G. Maguire, Gui-Shuang Ying, Juan E. Grunwald, Jiayan Huang
Journal: Ophthalmology (2013)
Combined Bone Marrow and Gallium Imaging
Authors: CHARLES E. KAHN, JAMES W. RYAN, MALCOLM K. HATFIELD, WILLIAM B. MARTIN
Journal: Clinical Nuclear Medicine (1988)

The clinical records and scintigrams of patients with sickle hemoglobinopathy who underwent combined Tc-99m bone marrow imaging and Ga-67 imaging to differentiate osteomyelitis from bony infarction were reviewed. Of 18 paired examinations in 15 patients, osteomyelitis was diagnosed correctly in six cases; in all six, gallium uptake at the symptomatic site was incongruently increased relative to the bone marrow activity. Of the 12 episodes of infarction, 11 showed congruent activity on both Tc-99m and Ga-67 images. The remaining study was interpreted incorrectly as osteomyelitis due to incongruent Tc-99m and Ga-67 uptake. The use of sequential Tc-99m bone marrow and Ga-67 imaging is an effective means of distinguishing osteomyelitis from bony infarction in patients with sickle hemoglobinopathy.
Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor type 3, glycoprotein p150,95 in a girl with recurrent bacterial infections. Effects on phagocytic cells and lymphocyte functions.
Authors: A Fischer, R Seger, A Durandy, B Grospierre, J L Virelizier, F Le Deist, C Griscelli, E Fischer, M Kazatchkine, M C Bohler
Journal: Journal of Clinical Investigation (1985)

A patient presenting delayed umbilical cord detachment, severe recurrent bacterial infections, and inability to form pus exhibited a profound defect in the expression of alpha- and beta-chains of the receptor for the C3bi fragment of C3 (CR3), lymphocyte function antigen 1 (LFA-1) molecule, and the p150,95 molecule found on neutrophils, monocytes, and lymphocyte membranes. This was shown by immunofluorescence studies using specific monoclonal antibodies, rosette formation with C3bi-coated erythrocytes, and immunoprecipitation for the LFA-1 complex. These membrane defects were responsible for abnormal phagocytic cell functions including adherence to nylon wool, cell movement, phagocytosis, and opsonized particle-induced oxidative response and for defective natural killer cell activity. In addition, lymphocyte function deficiencies previously unobserved in this disease were found. Cytolytic T lymphocyte activity was profoundly reduced; alpha- and gamma-interferon production were impaired. Finally, there was no antibody production to vaccinal antigens whereas the antibody responses to polysaccharides and to cytomegalovirus were found to be normal. The cytotoxic T cell deficiency could be expected from previous blocking experiments of this function with monoclonal antibodies to LFA-1 and is probably related to an extremely severe deficiency in LFA-1 expression in this patient. Anomalies in interferon and in antibody production suggest additional role(s) of the LFA-1 complex in monocyte/T lymphocyte/B lymphocyte cell interactions that have not yet been envisaged.
Mortality Among Workers at Oak Ridge National Laboratory
Authors: Steve Wing
Journal: JAMA (1991)

White men hired at the Oak Ridge (Tenn) National Laboratory between 1943 and 1972 were followed up for vital status through 1984 (N = 8318, 1524 deaths). Relatively low mortality compared with that in US white men was observed for most causes of death, but leukemia mortality was elevated in the total cohort (63% higher, 28 deaths) and in workers who had at some time been monitored for internal radionuclide contamination (123% higher, 16 deaths). Median cumulative dose of external penetrating radiation was 1.4 mSv; 638 workers had cumulative doses above 50 mSv (5 rem). After accounting for age, birth cohort, a measure of socioeconomic status, and active worker status, external radiation with a 20-year exposure lag was related to all causes of death (2.68% increase per 10 mSv) primarily due to an association with cancer mortality (4.94% per 10 mSv). Studies of this population through 1977 did not find radiation-cancer mortality associations, and identical analyses using the shorter follow-up showed that associations with radiation did not appear until after 1977. The radiation-cancer dose response is 10 times higher than estimates from the follow-up of survivors of the bombings of Hiroshima and Nagasaki, Japan, but similar to one previous occupational study. Dose-response estimates are subject to uncertainties due to potential problems, including measurement of radiation doses and cancer outcomes. Longer-term follow-up of this and other populations with good measurement of protracted low-level exposures will be critical to evaluating the generalizability of the results reported herein.
Periosteal Preservation in Operative Surgery
Authors: W. Stokes
Journal: BMJ (1868)

YOKEL 70,&-RM1-.a~nt an terangle.Had I thecWseto treatV'eiapin I shotld Petfrftn Kthetenotomy at the same time as the'minipetaton.-But eitept the 4loss of time that 'has occurred, 4he retilt is -inatlysfl that could 'be wnshed.Under the use of a-Soaparsshoefhe has continued to imprTve ,steadily, and when I last -saw him, in the early part of September,
Severe neutrophilia induced by infliximab for psoriasis
Authors: J.P. de Oliveira, A. Levy, P. Morel, F. Guibal
Journal: British Journal of Dermatology (2007)

Journal Article Severe neutrophilia induced by infliximab for psoriasis Get access J.P. De Oliveira, J.P. De Oliveira Service de Dermatologie, Hôpital Saint‐Louis, 1 avenue Claude Vellefaux, 75475 Paris cedex 10, France Search for other works by this author on: Oxford Academic Google Scholar A. Levy, A. Levy Service de Dermatologie, Hôpital Saint‐Louis, 1 avenue Claude Vellefaux, 75475 Paris cedex 10, France Search for other works by this author on: Oxford Academic Google Scholar P. Morel, P. Morel Service de Dermatologie, Hôpital Saint‐Louis, 1 avenue Claude Vellefaux, 75475 Paris cedex 10, France Search for other works by this author on: Oxford Academic Google Scholar F. Guibal F. Guibal Service de Dermatologie, Hôpital Saint‐Louis, 1 avenue Claude Vellefaux, 75475 Paris cedex 10, France Correspondence: Fabien Guibal. E‐mail: fabien.guibal@sls.aphp.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 1, 1 January 2008, Pages 200–201, https://doi.org/10.1111/j.1365-2133.2007.08319.x Published: 01 January 2008
Erratum: “Secondary clonal cytogenetic abnormalities following successful treatment of acute promyelocytic leukemia” by Batzios et al. <i>Am J Hematol</i> 84:715‐719, 2009, DOI number 21528
Authors: Crisoula Batzios, Lachlan A. Hayes, Simon Z. He, Hang Quach, Zoe K. McQuilten, Meaghan Wall, Lynda J. Campbell
Journal: American Journal of Hematology (2010)

In the above mentioned article, an error has been identified in the description of patients being treated in the APML3 study. Only patients 2, 8 and 11 were actually enrolled in the ALLG APML3 trial. Patient 6 was enrolled but subsequently deemed ineligible. Patients 5, 6, 7, 9, 10 and 12 were treated off study using the ALLG APML3 trial protocol. We apologize for any confusion that this might have caused.
Attention Disorder in Children: Is the Literature Purged? Was It Ever Tainted?-Reply
Authors: Sally E. Shaywitz
Journal: JAMA (1989)

<h3>In Reply.—</h3> Dr Knoll asks why the recent reports in<i>JAMA</i>fail to "acknowledge the taint that Breuning's influential work must have brought to the literature in this area?" At the most obvious level, we did not reference Breuning (nor did any of the authors referenced in our editorial) because his reports were not relevant to our discussion. Safer and Krager<sup>1</sup>reference only one article referring to stimulant therapy in the mentally retarded (reference 13), and no references to Breuning appeared in this source either. There are several possibilities for the lack of references to Breuning in any of these sources. One possibility, apparent from the tone of Dr Knoll's letter, is that there is some sort of scientific cover-up: investigators either consciously or unconsciously "have cleaned up the literature." A more likely explanation for the absence of any reference to Breuning is that many investigators have no reason
Is the Ultimatum Game a three-body affair?
Authors: Gerd Gigerenzer, Thalia Gigerenzer
Journal: Behavioral and Brain Sciences (2005)

The Ultimatum Game is commonly interpreted as a two-person bargaining game. The third person who donates and may withdraw the money is not included in the theoretical equations, but treated like a neutral measurement instrument. Yet in a cross-cultural analysis it seems necessary to consider the possibility that the thoughts of a player – strategic, altruistic, selfish, or concerned about reputation – are influenced by both an anonymous second player and the non-anonymous experimenter.
Esophageal Stricture Following Chloral Hydrate Poisoning
Authors: Gerald J. Gleich
Journal: JAMA (1967)

Following ingestion of 18 gm of chloral hydrate, a patient first showed evidence of gastrointestinal bleeding, and later an esophageal stricture developed. Awareness of the latter complication of chloral hydrate poisoning is important because of the efficacy of corticosteroid drugs in the prevention of esophageal stricture.