LIPIDS AND ATHEROSCLEROSIS
Authors: MILTON S. SACKS
Journal: Annals of Internal Medicine (1951)

Editorial1 October 1951LIPIDS AND ATHEROSCLEROSISMILTON S. SACKS, M.D.MILTON S. SACKS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-4-938 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough some 40 years have elapsed since Windaus1reported the predominance of cholesterol and its esters in human atherosclerotic lesions and Anitschkow2produced experimental atherosclerosis in the rabbit by the feeding of cholesterol, an etiological hypothesis, capable of verification at every step, is still a matter of the future. Experimental investigation at present is quite active and is no longer hampered by the dictum that human atherosclerosis is an inevitable concomitant of the process of aging. The volume of investigations dealing with the relationship of lipid metabolism to atherosclerosis has reached staggering proportions, but the results are still controversial. Recently...1 Windaus A: Ueber den Gehalt normalen und atheromatosen Aorten an Cholesterin und Cholesterinestern, Ztschr. f. physiol. Chem. 67: 174, 1910. CrossrefGoogle Scholar2 Anitschkow N: Experimental atherosclerosis in animals, Chapter 10 in Arteriosclerosis, E. V. Cowdry, ed., 1933, The Macmillan Co., N. Y. Google Scholar3 GubnerUngerleider RHE: Arteriosclerosis: a statement of the problem, Am. J. Med. 6: 60, 1949. CrossrefMedlineGoogle Scholar4 BlixTiseliusSvensson GAH: Lipids and polysaccharides in electrophoretically separated blood serum proteins, J. Biol. Chem. 137: 485, 1941. CrossrefGoogle Scholar5 Frazer AC: The absorption of triglyceride fat from the intestine, Physiol. Rev. 26: 104, 1946. CrossrefGoogle Scholar6 GageFish SHPA: Fat digestion, absorption and assimilation in man and animals as determined by the dark field microscope and a fat-soluble dye, Am. J. Anat. 34: 1, 1924. CrossrefGoogle Scholar7 ElkesFrazerStewart JJACHC: The composition of particles seen in normal human blood under dark-ground illumination, J. Physiol. 95: 68, 1939. CrossrefMedlineGoogle Scholar8 Thannhauser SJ: Serum lipids and their value in diagnosis, N. Eng. J. Med. 237: 515, 1947. CrossrefMedlineGoogle Scholar9 AhrensKunkel EHHG: The stabilization of serum lipid emulsions by serum phospholipids, J. Exper. Med. 90: 409, 1949. CrossrefMedlineGoogle Scholar10 KellnerCorrellLadd AJWAT: The influence of intravenously administered surface-active agents on the development of experimental atherosclerosis in rabbits, J. Exper. Med. 93: 385, 1951. CrossrefMedlineGoogle Scholar11 DuffPayne GLTF: The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit. III. The mechanisms of the inhibition of experimental cholesterol atherosclerosis in alloxan-diabetic rabbits, J. Exper. Med. 92: 299, 1950. CrossrefMedlineGoogle Scholar12 GertlerGarnLerman MMSMJ: The interrelationships of serum cholesterol, cholesterol esters and phospholipids in health and in coronary artery disease, Circulation 2: 205, 1950. CrossrefMedlineGoogle Scholar13 BuckRossiter RCRJ: Lipids of normal and atherosclerotic aortas: a chemical study, Arch. Path. 51: 224, 1951. Google Scholar14 Hueper WC: Arteriosclerosis, a general review, Arch. Path. 39: 51, 1945. Google Scholar15 Moreton JR: Chylomicronemia, fat tolerance, and atherosclerosis, J. Lab. and Clin. Med. 35: 373, 1950. Google Scholar16 ZinnGriffith WJGC: A study of serum fat globules in atherosclerotic and non-atherosclerotic male subjects, Am. J. M. Sc. 220: 597, 1950. CrossrefMedlineGoogle Scholar17 Hahn PF: Abolishment of alimentary lipemia following injection of heparin, Science 98: 19, 1943. CrossrefMedlineGoogle Scholar18 BlockVannBarker WJFDNW: Effect of small doses of heparin in increasing the translucence of plasma during alimentary lipemia: Studies in normal individuals and patients with atherosclerosis, Proc. Staff Meet., Mayo Clin. 26: 246, 1951. MedlineGoogle Scholar19 GofmanJonesLindgrenLyonElliottStrisower JWHBFTTPHAB: Blood lipids and human atherosclerosis, Circulation 2: 161, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MILTON S. SACKS, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErnährungskrankheiten 1 October 1951Volume 35, Issue 4Page: 938-943KeywordsAgingAtherosclerosisCholesterolForecastingLesionsLipid metabolismLipidsRabbits ePublished: 1 December 2008 Issue Published: 1 October 1951 PDF downloadLoading ...