tbuckley/cabot-search huggingface dataset:
Impaired lymphocyte cyclic adenosine mono-phosphate responses in atopic eczema
Authors: C. B. ARCHER, J. MORLEY, D. M. MACDONALD
Journal: British Journal of Dermatology (1983)

Journal Article Impaired lymphocyte cyclic adenosine mono‐phosphate responses in atopic eczema Get access C. B. ARCHER, C. B. ARCHER Departments of Dermatology, Guy's Hospital, London, SE1 Search for other works by this author on: Oxford Academic Google Scholar J. MORLEY, J. MORLEY Clinical Pharmacology, Cardiothoracic Institute, Brompton Hospital, London, SW3 Search for other works by this author on: Oxford Academic Google Scholar D. M. MACDONALD D. M. MACDONALD Departments of Dermatology, Guy's Hospital, London, SE1 Dr D. M. MacDonald, Department of Dermatology, Guy's Hospital, St Thomas' Street, London, SE1 9RT. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 109, Issue 5, 1 November 1983, Pages 559–564, https://doi.org/10.1111/j.1365-2133.1983.tb07679.x Published: 01 November 1983 Article history Accepted: 12 April 1983 Published: 01 November 1983
Cholesterol Emboli after Coronary Angioplasty
Authors: Omar Rana, William McCrea
Journal: New England Journal of Medicine (2006)

A 72-year-old man presented with unstable angina. An urgent cardiac catheterization showed clinically significant disease in the right coronary artery, which was stented. Twelve hours after the procedure, livedo reticularis developed on his legs and there was a bluish discoloration of his toes (Panels A and B). The evaluation was notable for an increase in his serum creatinine level from 1.5 mg per deciliter (135 μmol per liter) to 3.1 mg per deciliter (276 μmol per liter), eosinophilia of 7.4 percent, and a normal result on renal ultrasonography. A diagnosis of cholesterol emboli was made. The patient recovered uneventfully.
The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach
Authors: F E B May
Journal: Gut (2000)

<h3>BACKGROUND</h3> TFF2, a member of the trefoil factor family (TFF) of peptides, is a secreted protein of 106 amino acids that is expressed in mucous neck cells of the fundus and glands at the base of the antrum in normal human stomach. TFF2 is also detected at high concentrations around sites of ulceration. It is protective against mucosal damaging agents and stimulates cell motility. <h3>AIMS</h3> To measure the expression of TFF2 in normal human stomach and its secretion into gastric juice. <h3>METHODS</h3> TFF2 cDNA was amplified by reverse transcription polymerase chain reaction from gastric mucosa and sequenced. Gastric juice or cytosol, prepared from gastric mucosa, was obtained from individuals with macroscopically normal stomachs. TFF2 concentrations were measured by quantitative western transfer analysis. <h3>RESULTS</h3> Sequencing of TFF2 cDNA revealed a single amino acid change from the published sequence. Significant amounts of 12 kDa TFF2 were detected in human gastric juice. Larger quantities of a protein of higher apparent molecular mass were also detected. This was shown to be N-glycosylated TFF2 using the endoglycosidase, peptide-N-Gycosidase F. The majority of TFF2 in normal gastric mucosa was also glycosylated. <h3>CONCLUSIONS</h3> Human TFF2 is glycosylated via an N-linkage, presumably on Asn<sup>15</sup> which forms part of the single consensus site for N-glycosylation in human TFF2. The glycosylation may be of functional significance. Future studies of human TFF2 should use antibodies raised against the correct amino acid sequence. Biological studies should be performed with recombinant protein of the correct sequence, and the biological consequences of glycosylation investigated.
Random donor platelet crossmatching: Comparison of four platelet antibody detection methods
Authors: J. Freedman, M. B. Garvey, A. Hornstein, Z. Salomon De Friedberg, V. Blanchette
Journal: American Journal of Hematology (1988)

The standard lymphocytotoxicity assay (LCT), a biotin-avidin enzyme immunoassay (ELISA), platelet suspension immunofluorescence test (PSIFT), and platelet radioactive antiglobulin test (PRAT) were examined in prospective crossmatching for selection of compatible random donor platelets for refractory patients. One hundred seven episodes of pooled random donor platelet transfusions were evaluated in 26 patients. There was good reproducibility of results by individual techniques. Concordance of results by the different methods was 40-60%. One-hour and 24 hr posttransfusion corrected count increments (CCI) were compared as parameters for assessing success or failure of the transfusion. Using a rank scoring system, the relative efficiency of predictiveness for all transfusions was PRAT greater than LCT greater than PSIFT greater than ELISA. Combination of PRAT and LCT afforded the best predictability and sensitivity was higher than for either PRAT or LCT alone (93 vs. 79 and 62%, respectively). Mean posttransfusion CCI (x 10(9)/L) following PRAT-compatible platelets was 13.9 +/- 12.7 at 1 hr and 7.3 +/- 6.9 at 24 hr; following PRAT-incompatible platelets, 5.7 +/- 7.8 (1 hr) and 2.1 +/- 4.1 (24 hr). Results were similar for LCT-tested platelets. A radioimmunofiltration modification of the PRAT developed and used in selected cases was simple, fast, efficient, and inexpensive. The study indicated that the techniques evaluated are practical and feasible for routine use in the provision of compatible random donor platelets to the refractory patient who has no other cause for increased platelet destruction.
Research on aging burgeons as more Americans grow older
Authors: M. F. Goldsmith
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gamma-globulin for Prevention of Rubella in Pregnancy
Authors: R. E. Smith
Journal: BMJ (1963)

operations, used the same triad of anti- biotics in an aerosol pack (polybactrinspray), and reported a significant decrease in post-operative wound infection.Forty-two cases have been treated with the same antibiotic triad presented in a soluble form, and, with one exception, responded well.The exception was completely resistant.Treatment was stopped on a further patient who revealed an idiosyncrasy to the antibiotics.Our method is to irrigate the sinus with a solution of the antibiotic and in certain cases to pack the cavity with a ribbon gauze soaked in the solution.Using this technique we find the time required to control the purulent and offensive discharge is four days, as opposed to the ten days normally experi- enced with other treatments.Quite apart from the quicker turn-round of patents, the unquestionable improvement in the wound toilet is invaluable both to the patient's morale and to the nursing staff.-I am, etc.,
Psychotherapy of the Mentally Retarded
Authors: George M. Lott
Journal: JAMA (1966)

Some types of the mentally retarded need psychotherapy included in an effective treatment program, and such therapy may be prescribed by their physicians. Accumulated knowledge reveals that the retarded comprise a conglomerate of etiologies and conditions, which require individualized comprehensive remedial plans. These youngsters have the same emotional conflicts, frustration, and guilt feelings as do normals, usually with less ability to correlate experiences and resist flattening feelings of failure. They need opportunities for relative successes. Some case illustrations are included, with special reference to psychotherapeutic processes. In those children with primary or secondary emotional problems, psychotherapy, supportive or deep, is not a holistic remedy. However, it may represent the difference between some degree of community adjustment and protected institutional living or hospital refuge. Long experience indicates the need for coordinated work with the parents.
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity
Authors: Douglas W McMillin, Jake Delmore, Ellen Weisberg, Joseph M Negri, D Corey Geer, Steffen Klippel, Nicholas Mitsiades, Robert L Schlossman, Nikhil C Munshi, Andrew L Kung, James D Griffin, Paul G Richardson, Kenneth C Anderson, Constantine S Mitsiades
Journal: Nature Medicine (2010)
Naproxen in Rheumatoid Arthritis
Authors: DONN E. BOWERS
Journal: Annals of Internal Medicine (1975)

The efficacy of naproxen in treating rheumatoid arthritis patients was evaluated in a double-blind clinical trial using aspirin as the control drug. The study was conducted at seven centers and involved 80 patients. After an unequivocal increase in disease activity during a drug-free period, patients were randomly assigned to either drug and continued in the trial for 16 weeks. Some patients took low maintenance doses of corticosteroids, or gold salts, or both throughout the trial. Both test drugs significantly decreased disease activity as measured by a number of ways. By objective measurements, naproxen was as effective as aspirin, although patients in the naproxen-treated group entered the trial with more severe disease. By some subjective evaluations, naproxen was considered more effective than aspirin. Although patients taking naproxen had less frequent gastrointestinal side effects and fewer symptoms VIIIth nerve toxicity, the differences were not statistically significant. We conclude that naproxen is a useful addition to the physician's armamentarium for the treatment of rheumatoid arthritis.
When I use a word . . .: A time to be born . . .
Authors: J. Aronson
Journal: BMJ (1997)

There is a widespread myth that births occur more commonly at around the time of a full moon. It is certainly true that time has always been associated with reproduction in one way or another. The earliest known word for time (see Gegenbaurs Morph Jahrb 1982;128:257-89) was probably the Acadian word ittum, which originally meant a momentous event, such as an eclipse of the moon or a monstrous birth. This itself gave birth to the Hebrew word for time, eht, the Etruscan word for the time of the full moon, itus, and hence the Greek ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>o![Graphic][4]</img> (eidoi) and the Latin Idus, words for the day of the month (the Ides) that fell near the full … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
DOMESTIC CORRESPONDENCE.
Authors: W.P. HOWLE
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-860 Does the Logistic EuroSCORE II Better Predict Outcomes Following Transcatheter Aortic Valve Implantation? Results from the Milan Registry
Authors: Gill Buchanan, Alaide Chieffo, Matteo Montorfano, Azeem Latib, Francesco Maisano, Micaela Cioni, Filippo Figini, Mauro Carlino, Chiara Bernelli, Santo Ferrarello, Alessandro Durante, Chiara Gerli, Annalisa Franco, Remo Covello, Eustachio Agricola, Giovanni La Canna, Pietro Spagnolo, Angela Ferrari, Ottavio Alfieri, Antonio Colombo
Journal: Journal of the American College of Cardiology (2012)
Impact of age and sex on primary preventive treatment for cardiovascular disease in the West Midlands, UK: cross sectional study
Authors: J. P. Sheppard, S. Singh, K. Fletcher, R. J. McManus, J. Mant
Journal: BMJ (2012)

<b>Objectives</b> To establish the impact of age and sex on primary preventive treatment for cardiovascular disease in a typical primary care population. <b>Design</b> Cross sectional study of anonymised patient records. <b>Participants</b> All 41 250 records of patients aged ≥40 registered at 19 general practices in the West Midlands, United Kingdom, were extracted and analysed. <b>Main outcome measures</b> Patients' demographics, risk factors for cardiovascular disease (blood pressure, total cholesterol concentration), and prescriptions for primary preventive drugs were extracted from patients' records. Patients were subdivided into five year age bands up to 85 (patients aged ≥85 were analysed as one group) and prescribing trends across the population were assessed by estimating the proportion of patients prescribed with antihypertensive drug or statin drug, or both, in each group. <b>Results</b> Of the 41 250 records screened in this study, 36 679 (89%) patients did not have a history of cardiovascular disease and therefore could be considered for primary preventive treatment. The proportion receiving antihypertensive drugs increased with age (from 5% (378/6978) aged 40-44 to 57% (621/1092) aged ≥85) as did the proportion taking statins up to the age of 74 (from 3% (201/6978) aged 40-44 to 29% (675/2367) aged 70-74). In those aged 75 and above, the odds of a receiving prescription for a statin (relative to the 40-44 age group) decreased with every five year increment in age (odds ratio 12.9 (95% confidence interval 10.8 to 15.3) at age 75-79 to 5.7 (4.6 to 7.2) at age ≥85; P&lt;0.001). There were no consistent differences in prescribing trends by sex. <b>Conclusions</b> Previously described undertreatment of women in secondary prevention of cardiovascular disease was not observed for primary prevention. Low use of statins in older people highlights the need for a stronger evidence base and clearer guidelines for people aged over 75.
Cimetidine and Giant Urticaria
Authors: WILLIAM A. HADFIELD
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 July 1979Cimetidine and Giant UrticariaWILLIAM A. HADFIELD JR., M.D.WILLIAM A. HADFIELD JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The use of cimetidine for the treatment of peptic ulcer disease is now well established. Adverse reactions to the drug have been reported, but there have been no reports of dermatologic reactions. In its literature under adverse reactions, the manufacturer lists a rash but does not indicate the type of rash that has been observed. This prompts my reporting of the following case.A 46-year-old woman, with chronic duodenal ulcer disease developed typical recurrent ulcer symptoms in August 1978. During a 3-week period she took cimetidine, 300 mg four times daily, with good relief of her complaints.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Delaware County Memorial Hospital Drexel Hill, PA 19026 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug ReactionsLichenoid and subacute cutaneous lupus erythematosus-like dermatitis associated with antihistamine therapyAdverse Reactions and Interactions with H2-Receptor AntagonistsHypersensitivity to CimetidineCimetidine-induced cutaneous vasculitisThe metabolism of [ 14 C]cimetidine in manAntihistamines 1 July 1979Volume 91, Issue 1Page: 128-129KeywordsAdverse reactionsDuodenal ulcersPeptic ulcersRashesUrticaria Issue Published: 1 July 1979 PDF DownloadLoading ...
EXACT INFANT-FEEDING: ACCIDENTS AND INCIDENTS.
Authors: W. P. NORTHRUP
Journal: JAMA (1900)

The object of this paper is to call attention to the accidents which may arise from the very exactness of the methods employed. I do not mean to say the accidents arc inherent in the methods; I am going to call your attention to certain responsibilities on the part of the physician. Accidents may arise in mechanical ways; they may arise from faults of a higher order. Let us assume that we are agreed upon the following: 1. That cow's milk is the only variety of milk to be considered in substitute feeding. 2. That dairy cleanliness is necessary. 3. That the modification of milk according to some definite formula is demanded. 4. That it is desirable to have the milk modified in a laboratory for purposes of cleanliness and exactness. The discussion of the respective values of gravity and centrifugated cream does not enter into consideration here; a laboratory
Abstract 3941: Amplifications of drug target genes in gastric cancer: Potential clinical implications
Authors: Mariette Labots, Josien C. Haan, Tineke E. Buffart, Nicole CT van Grieken, Marianne Tijssen, Bauke Ylstra, Beatriz Carvalho, Cornelis JH van de Velde, Heike I. Grabsch, Henk MW Verheul, Remond JA Fijneman, Gerrit A. Meijer
Journal: Cancer Research (2011)

Abstract Background: The treatment of advanced gastric cancer remains a challenge for the clinical oncologist. Once distant metastases are present, median survival is around one year with the most active chemotherapeutic regimen. Besides the recent approval of trastuzumab in combination with chemotherapy, thus far no other molecular targeted agents have been approved for the treatment of this disease. There is an urgent need to improve selection of effective treatment for individual patients. A potentially promising approach for selecting active antitumor agents in individual patients could be the evaluation of tumor DNA for amplifications of genes coding for drug targets. Material and Methods: 183 primary gastric adenocarcinomas were analyzed by genome wide array Comparative Genomic Hybridization (arrayCGH) using microarrays consisting of 5000 BAC clones. High level amplifications were defined as a minimum of 2 consecutive clones showing a log2 tumor to normal ratio of &amp;gt; 1. Amplification frequencies for each BAC clone were calculated among the 183 tumors, and genes located within the amplicons were identified by using the RefSeq genes in the UCSC genome browser, version hg16/NCBI34. Drug target genes were selected with Ingenuity Pathway Analysis (IPA) and the Pharmacogenomics Knowledge Base (PharmGKB). Genes amplified in at least 4 patients (2%) were classified according to the mechanism of action of the drug interacting with this specific gene. Results: In 183 gastric cancers a mean number of 2.0 amplifications per tumor (range 0-21) was found. 167 genes out of more than 6000 at these loci were annotated as drug target genes by IPA, with 30 genes having an amplification frequency of at least 4 (2%). Most frequently amplified regions were located on chromosome 6, 8, 11, 16, 17 and 20. Genes for molecular targeting agents included VEGFA (6.5%), ERBB2 (6%), HSP90AB1 (5.5%) and EGFR (3.8%). Interestingly, also genes for non-anticancer agents, including HRH3 (10.4 %) and RARA (4.9%), and potential therapeutic targets such as TNFRSF4B (7.1%) were found. Conclusion: ArrayCGH analysis of a large series of gastric tumors revealed many non-randomly amplified gene loci, including substrates for targeted agents with potential antitumor activity in advanced gastric cancer. Moreover, targets of agents without established anticancer activity were identified as well. Our results provide a molecular rationale for the investigation of new treatment strategies in advanced gastric cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3941. doi:10.1158/1538-7445.AM2011-3941