Familial Amyloid-producing Medullary Thyroid Carcinoma and Pheochromocytoma
Authors: R. NEIL SCHIMKE
Journal: Annals of Internal Medicine (1965)

Article1 December 1965Familial Amyloid-producing Medullary Thyroid Carcinoma and PheochromocytomaA Distinct Genetic EntityR. NEIL SCHIMKE, M.D., WILLIAM H. HARTMANN, M.D.R. NEIL SCHIMKE, M.D., WILLIAM H. HARTMANN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-1027 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptConsiderable attention has of late been focused on heritable disorders of the endocrine system. The inborn errors of thyroid and adrenal metabolism have been fairly well characterized and have been the subjects of recent reviews (1, 2). Although the exact mode of inheritance remains to be established, diabetes mellitus appears to have a strong genetic component. Multiple endocrine adenomas, primarily involving pituitary, pancreas, and parathyroids, have also been described in multiple members of some families (3), and the syndrome appears to be genetically well defined (4). Pheochromocytoma has likewise been found to occur in familial aggregates, either alone (5) or...References1. STANBURY JB: Familial goiter, in The Metabolic Bases of Inherited Disease, edited by STANBURY, J. B., WYNGAARDEN, J. B., FREDRICKSON, D. S. McGraw-Hill, New York, 1960, p. 273. Google Scholar2. BONGIOVANNIROOT AMAW: The adrenogenital syndrome. New Eng. J. Med. 268: 1283, 1342, 1391, 1963. CrossrefMedlineGoogle Scholar3. BALLARDFRAMEHARTSOCK HSBRJ: Familial multiple endocrine adenoma-peptic ulcer complex. Medicine (Balt.) 43: 481, 1964. CrossrefMedlineGoogle Scholar4. WERMER P: Endocrine adenomatosis and peptic ulcer in a large kindred. Inherited multiple tumors and mosaic pleiotropism in man. Amer. J. Med. 35: 205, 1963. CrossrefMedlineGoogle Scholar5. 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Neil Schimke, M.D., Department of Medicine, Kansas University Medical School, Kansas City, Kan. 66103. 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