tbuckley/cabot-search huggingface dataset:
Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation
Authors: Julie Agostini, Stéphane Benoist, Marie Seman, Catherine Julié, Sandrine Imbeaud, Franck Letourneur, Nicolas Cagnard, Philippe Rougier, Antoine Brouquet, Jessica Zucman-Rossi, Pierre Laurent-Puig
Journal: Journal of Hepatology (2011)
Bystander memory CD8 T cell proliferation after anti-CD40/IL-2 treatment is independent of CD4 T cells
Authors: Steven K Grossenbacher, Arta M Monjazeb, Julia Tietze, Gail D Sckisel, Annie Mirsoian, Hui-Hua Hsiao, Brent Koehn, Danice Wilkins, Bruce R Blazer, William J Murphy
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Systemic cancer immunotherapy combining agonistic anti-CD40 and interleukin 2 results in synergistic anti-tumor effects with marked antigen independent expansion of bystander memory CD8 T cells displaying anti-tumor abilities. Our lab has previously shown that this expansion
LOUISIANA STATE MEDICAL SOCIETY
Authors: B. A. Ledbetter
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholesterol lowering treatment and mortality.
Authors: J. G. Schmidt
Journal: BMJ (1992)

a large true association.In contrast, a weak confounding effect is hard to detect and can plague weak associations that is, associations with relative risks smaller than 2 0. It can either produce spurious associations or mask true associations.Therefore, the warning against confounding bias raised by Smith and Phillips applies really to the study of weak associations.It is certainly true that weak associations should be interpreted with caution because there is no certainty that all confounding effects have been neutralised.Nevertheless, as long as the menace of confounding bias remains a purely theoretical exercise, there is no ground to give more credit to sceptical debunking of a suspected relative risk rather than to a postulated biological mechanism supporting its plausibility.
Website of the week: Managing chronic diseases: kids' stuff
Authors: A. Moscrop
Journal: BMJ (2001)

When children are considered in the context of chronic diseases, it is often with a view to preventing the problems of adult onset cancer and heart disease. In Britain, the Department of Health has initiated a National School Fruit Scheme for children to “protect them against chronic diseases in later life.” At the website (www.doh.gov.uk/schoolfruitscheme/), statistics show that eating green stuff remains among the least favourite activities of most children: “About half eat no peas and three in five eat no leafy green vegetables.”

Sadly, chronic illness is not always confined to a child's distant future. Many children are affected by chronic diseases. The internet can be an ideal means of providing these children with knowledge and support.

The National Asthma Campaign website contains a “kids' zone” (www.asthma.org.uk/kidszone/) that offers advice on coping with asthma attacks and attempts to provide answers to questions such as “What is asthma?” and “Why do I have asthma?” The “youth site” of Coeliac UK (www.coeliac.co.uk) combines education with entertainment, interspersing its information with interactive space invaders games. Diabetes UK (www.diabetes.org.uk/manage/teenzone/sort_it.htm) provides information relevant to teenagers. It offers advice on alcohol consumption and interactions between recreational drugs and insulin and glucose levels, along with strategies for gaining independence from protective parents.

“Band-aides and Blackboards” (www.faculty.fairfield.edu/fleitas/contents.html) aims to provide age appropriate information for all children with chronic illnesses and to educate others (parents, teachers, other children, etc) on what it's like to grow up with a chronic medical condition. It addresses issues of stigma, fear, and coping at school and in hospital through the use of stories and children's personal accounts. “I have a ‘hidden’ medical problem. Most of the time nobody can see it, but sometimes I get very big bruises because of it,” says 9 year old J J, who has haemophilia.

“Band-aides and Blackboards” deserves commendation to all. Could a website that promotes understanding and acceptance of children with chronic illness be more valuable than a Department of Health initiative promoting the consumption of cabbage?
THE NAMES OF PROPRIETARY PREPARATIONS
Authors: Oliver T Osborne
Journal: JAMA (1923)

<h3>To the Editor:</h3> —May I express my most sincere approval of the ruling of the Council on Pharmacy and Chemistry for excluding from New and Nonofficial Remedies drugs (however valuable their therapeutic action may be, or however honestly described their chemical constituency) not distinctly named to show the active drug that they contain. Esterol should be "benzyl succinate," prepared by Frederick Stearns &amp; Company. It should be<i>suggested</i>by its name that any drug or preparation acts differently from the basic drug it contains. A drug or preparation should be ordered by its name, and then the preferred maker specified, if desired. For instance: Elixir Glycerophosphates (the name of the maker of the preparation desired); Antipneumococcic Serum (the name of the maker of the preparation desired); Novocaine (the name of the maker of the preparation desired); Aromatic Fluidextract of Cascara (the name of the maker of the preparation desired); Fluidextract
Genes for Apolipoprotein B and Microsomal Triglyceride Transfer Protein Are Expressed in the Heart
Authors: Lars B. Nielsen, Murielle Véniant, Jan Borén, Martin Raabe, Jinny S. Wong, Carmen Tam, Laura Flynn, Teresa Vanni-Reyes, Michael D. Gunn, Ira J. Goldberg, Robert L. Hamilton, Stephen G. Young
Journal: Circulation (1998)

Expression of both the apolipoprotein B (apoB) gene and the microsomal triglyceride transfer protein (MTP) gene is required for the assembly and secretion of triglyceride-rich lipoproteins in the liver and intestine. Both genes have been assumed to be silent in the heart.Northern blot and RNase protection analyses showed that the apoB and MTP genes were expressed in the hearts of mice and humans. In situ hybridization studies revealed that the apoB mRNA was produced in cardiac myocytes. Electron microscopy of human cardiac myocytes revealed lipid-staining particles of relatively small diameter (approximately 250 A) within the Golgi apparatus.These studies strongly suggest that the heart synthesizes and secretes apoB-containing lipoproteins.
735-3 A Study of 1044 Consecutive Patients with Patent Foramen Ovale: Association with Cryptogenic Cerebrovascular Events in Adults
Authors: Sumita D. Paul, Mary Etta King, Michael H. Picard, Stella V. Brili, Peter Lang, John B. Newell, Richard R. Liberthson, Ariane J. Marelli
Journal: Journal of the American College of Cardiology (1995)
Preparation and properties of A-B-A type block copolymer membranes consisting of poly(N-hydroxypropyl-l-glutamine) as the A component and polyisoprene as the B component
Authors: Ryuichiro Yoda, Shigeru Komatsuzaki, Eiji Nakanishi, Haruma Kawaguchi, Toshio Hayashi
Journal: Biomaterials (1994)
810-4 Pexelizumab, a C5 complement inhibitor, reduces 30-day mortality in patients undergoing coronary artery bypass surgery or receiving reperfusion therapy for acute myocardial infarction
Authors: Frans J Van de Werf, Paul W Armstrong, Jerrold Levy, Christopher B Granger, Robert M Califf, Peter X Adams, Michael VanderLaan, Christopher Mojcik, Thomas G Todaro, Edward D Vernier
Journal: Journal of the American College of Cardiology (2004)
Arteriolar Abnormalities with Chronic Systemic Hypertension
Authors: RICHARD L. NAEYE
Journal: Circulation (1967)

A quantitative study of arteriolar structure has been undertaken in 23 individuals with chronic hypertension and 18 normotensive controls. In the hypertensive individuals, some arterioles were found to have an increased, and others a subnormal, mass of medial smooth muscle. Both abnormalities often bear a definite relation to arteriolar sclerotic lesions, those arterioles proximal to sclerotic segments having an increased medial coat and those distal, an atrophic coat. Mean values for mass of arteriolar muscle were often normal in organs of the hypertensive patients. These anatomic features can be correlated with a variety of physiological and clinical observations in the disorder.
The Year Is 2000; The Year Is 2025
Authors: Arthur Caplan
Journal: The American Journal of Bioethics (2013)

Click to increase image sizeClick to decrease image size Acknowledgments 1. See http://www.bioethicsinternational.org/blog/2011/02/01/gates-calls-for-a-final-push-to-eradicate-polio/ 2. See http://www.outsourcing-pharma.com/Preclinical-Research/Winners-and-losers-emerge-in-genomics-industry 3. See http://articles.cnn.com/2001-08-09/politics/bush.transcript_1_adult-cells-cell-lines-cell-research?_s=PM:ALLPOLITICS
MIBG and FDG PET Findings in a Patient With Malignant Pheochromocytoma: A Significant Discrepancy
Authors: Shabbir Ezuddin, Christina Fragkaki
Journal: Clinical Nuclear Medicine (2005)

Radionuclide imaging has proven to be very useful when dealing with neuroendocrine tumors and several radiotracers are currently available. One of the most commonly used and widely accepted methods to image pheochromocytomas is I-131 metaiodobenzylguanidine (MIBG) scintigraphy. However, recent studies with positron emission tomography (PET) using 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) in pheochromocytomas have shown that FDG PET imaging can be useful in those pheochromocytomas (usually malignant) that fail to accumulate MIBG. The therapeutic plan of malignant pheochromocytoma can include chemotherapy and/or a high dose of I-131 MIBG, so precise staging and characterization is mandatory for correct management and treatment.
Cost of Medical Care
Authors: William O. Robertson
Journal: JAMA (1977)

To the Editor. —  In regard to A Prescription for the Rising Cost of Medical Care (237:2383,1977), Vernon Mark, MD, has certainly succeeded in his aim of promoting debate. Unfortunately, his prescription is about as archaic as would be one prepared in the 1930s to treat a septic patient in the 1970s. For example, only after he has mentioned   four times does he drop the phrase  setting; apparently Dr Mark is unaware of the horrendous record of outpatient settings—particularly in municipal, county, and state hospitals—in terms of their nonresponsivity to patient care needs and their costs double to triple those of private office medicine. Also, does he, a neurosurgeon of all people, really advocate that all physicians be compensated at a uniform rate based on time? As a pediatrician, I might champion the concept, though it does ignore market place forces.  Most provocative is his indictment of
Appearance is more than shape, illumination, and pose
Authors: Jan-Olof Eklundh, Stefan Carlsson
Journal: Behavioral and Brain Sciences (1998)

Although we find the idea of representation by similarities attractive as such, we have two main objections to the specific proposal of Edelman. First, he does not consider complexity issues in terms of storage and speed of recall for recognition. Related to this, the appearance of objects depends on far more factors than just shape, illumination, and pose. This requires an intermediate shape abstraction process that extracts category-specific shape properties from the mixed appearance of images.
The Appropriateness of More Intensive Colonoscopy Screening Than Recommended in Medicare Beneficiaries
Authors: Frank van Hees, Ann G. Zauber, Carrie N. Klabunde, S. Luuk Goede, Iris Lansdorp-Vogelaar, Marjolein van Ballegooijen
Journal: JAMA Internal Medicine (2014)

Many Medicare beneficiaries undergo more intensive colonoscopy screening than recommended. Whether this is favorable for beneficiaries and efficient from a societal perspective is uncertain.To determine whether more intensive colonoscopy screening than recommended is favorable for Medicare beneficiaries (ie, whether it results in a net health benefit) and whether it is efficient from a societal perspective (ie, whether the net health benefit justifies the additional resources required).Microsimulation modeling study of 65-year-old Medicare beneficiaries at average risk for colorectal cancer (CRC) and with an average life expectancy who underwent a screening colonoscopy at 55 years with negative results.Colonoscopy screening as recommended by guidelines (ie, at 65 and 75 years) vs scenarios with a shorter screening interval (5 or 3 instead of 10 years) or in which screening was continued to 85 or 95 years.Quality-adjusted life-years (QALYs) gained (measure of net health benefit); additional colonoscopies required per additional QALY gained and additional costs per additional QALY gained (measures of efficiency).Screening previously screened Medicare beneficiaries more intensively than recommended resulted in only small increases in CRC deaths prevented and life-years gained. In comparison, the increases in colonoscopies performed and colonoscopy-related complications experienced were large. As a result, all scenarios of more intensive screening than recommended resulted in a loss of QALYs, rather than a gain (ie, a net harm). The only exception was shortening the screening interval from 10 to 5 years, which resulted in 0.7 QALYs gained per 1000 beneficiaries. However, this scenario was inefficient because it required no less than 909 additional colonoscopies and an additional $711 000 per additional QALY gained. Results in previously unscreened beneficiaries were slightly less unfavorable, but conclusions were identical.Screening Medicare beneficiaries more intensively than recommended is not only inefficient from a societal perspective; often it is also unfavorable for those being screened. This study provides evidence and a clear rationale for clinicians and policy makers to actively discourage this practice.
Is a warm house a medical intervention?
Authors: Douglas Kamerow
Journal: BMJ (2007)

You don't have to work very long taking care of poor people before you realize that the contents of our medical bag of tricks are often insufficient to improve their health status. One key contributor to ill health is the environment around the patient—do people smoke? Can the family afford healthy food? Is the home safe and warm?

The last of these is explored this week in a ground-breaking …
Cardiac hypertrophy in idiopathic dilated congestive cardiomyopathy: a clinicopathologic study.
Authors: I J Benjamin, E H Schuster, B H Bulkley
Journal: Circulation (1981)

Although clinical studies indicate that patients with idiopathic dilated congestive cardiomyopathy who develop electrocardiographic or angiographic signs of left ventricular (LV) hypertrophy may survive longer, there is little morphologic evidence for such anatomic favorable of unfavorable prognostic groups. We studied 30 autopsied patients who died of dilated cardiomyopathy; of these, 15 died within 1 year of the first symptom of their disease (short-term survivors) and 15 patients died 1-14 years after initial symptoms (long-term survivors). There were no significant differences in sex, race, clinical presentation or cause of death between the groups, but there were significant morphologic differences. In the short-term survivors, average heart weight was 540 g and LV wall thickness was 1.0 cm, whereas in the long-term survivors, the average heart weight was 759 g and LV wall thickness was 1.3 cm (p less than 0.001). LV cavity dilatation as measured by maximal transverse diameter from the postmortem angiograms did not differ between the two groups. These patients were compared with 10 autopsied patients with normal hearts and no clinical cardiac disease and 10 autopsied patients with volume overload secondary to valvular regurgitation. An LV hypertrophy/dilatation index (thickness/diameter) was 0.17 +/- 0.07 for the short-term survivors, 0.21 +/- 0.07 for the long-term survivors, 0.38 +/- 0.07 for volume overload patients, and 0.48 +/- 0.19 for normal subjects (F = 20.24, p less than 0.001). Thus, in patients with hypertrophy due to volume overload, wall thickening increased with dilatation, returning the ratio of wall thickness to cavity size toward normal. In contrast, among the idiopathic congestive cardiomyopathies, dilatation was disproportionate to hypertrophy and the difference was most marked for short-term survivors.
Inhibition of smooth muscle cell proliferation by an antisense oligodeoxynucleotide targeting the messenger RNA encoding proliferating cell nuclear antigen.
Authors: E Speir, S E Epstein
Journal: Circulation (1992)

The process by which normally quiescent vascular smooth muscle cells (SMCs) change into proliferating cells, which express and respond to multiple growth factors, plays a major role in restenosis after coronary angioplasty. We are attempting to inhibit SMC proliferation by interventions that inhibit specific factors involved in signal transduction pathways leading to cell division. To date, all studies taking this approach have attempted to block the effects of mitogens acting on the cell surface. In contrast, we have focused on a strategy that bypasses cell surface-mediated events by directly inhibiting the expression of proliferating cell nuclear antigen (PCNA), an intranuclear protein that functions in a final common pathway shared by diverse mitogen-induced signals. In the present investigation, we determined whether antisense oligodeoxynucleotides (ODNs) complementary to the messenger RNA of PCNA will inhibit PCNA expression and thereby reduce SMC proliferation.When antisense ODNs (15- or 18-mer), modified to inhibit their degradation, are introduced into the medium of rat aortic SMCs in concentrations ranging from 10 to 100 microM, the 18-mer ODN, in a concentration-related manner, decreases SMC growth (as assessed by cell counting) by more than 50%. This effect persists for at least 9 days. An ODN with the same nucleotides but a scrambled sequence has little effect. Western blots and immunocytochemistry indicate that the antisense ODN reduces expression of PCNA protein.Our results demonstrate that an antisense ODN directed at the messenger RNA of PCNA decreases expression of the PCNA gene product and reduces SMC proliferation. In addition, these results provide an important impetus to initiating in vivo studies to determine the feasibility of antisense strategies in the prevention of coronary restenosis.
VEIN GRAFT FAILURE FOLLOWING CORONARY ARTERY BYPASS SURGERY: DOES IT MATTER?
Authors: Renato Lopes, John H. Alexander, Rajendra H. Mehta, Gail E. Hafley, Michael J. Mack, Keith B. Allen, Eric D. Peterson, Robert A. Harrington, C. Michael Gibson, Robert M. Califf, Nicholas T. Kouchoukos, T. Bruce Ferguson
Journal: Journal of the American College of Cardiology (2010)
An Energy-Saving Development Initiative Increases Birth Rate and Childhood Malnutrition in Rural Ethiopia
Authors: Mhairi A Gibson, Ruth Mace
Journal: PLoS Medicine (2006)

Background Evolutionary life history theory predicts that, in the absence of contraception, any enhancement of maternal condition can increase human fertility. Energetic trade-offs are likely to be resolved in favour of maximizing reproductive success rather than health or longevity. Here we find support for the hypothesis that development initiatives designed to improve maternal and child welfare may also incur costs associated with increased family sizes if they do not include a family planning component. Methods and Findings Demographic and anthropometric data were collected in a rural Ethiopian community benefiting from a recent labour-saving development technology that reduces women's energetic expenditure ( n = 1,976 households). Using logistic hazards models and general linear modelling techniques, we found that whilst infant mortality has declined, the birth rate has increased, causing greater scarcity of resources within households. Conclusions This study is, to our knowledge, the first to demonstrate a link between a technological development intervention and an increase in both birth rate and childhood malnutrition. Women's nutritional status was not improved by the energy-saving technology, because energy was diverted into higher birth rates. We argue that the contribution of biological processes to increased birth rates in areas of the developing world without access to modern contraception has been overlooked. This highlights the continued need for development programmes to be multisectoral, including access to and promotion of contraception.
Characteristics of activation recovery interval dispersion from the whole chest in normal children and in children with prolonged QT
Authors: Naomi Izumida, Yuh Asano, Shouzaburoh Doi, Hiroko Wakimoto, Tadahiro Yoshikawa, Masatoshi Imamura, Natsuko Suzuki, Selko Kawano, Tohru Sawanobori, Masayasu Hiraoka
Journal: Journal of the American College of Cardiology (2002)
Deafness with Use of Dihydrostreptomycin in Tuberculous Meningitis
Authors: J. T. Naismith
Journal: BMJ (1952)

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Strontium 87m Scanning
Authors: Lynn T. Staheli
Journal: JAMA (1972)

Strontium 87m scanning was performed on 30 children with suspected infection involving the musculoskeletal system. All 20 patients, who in final analysis were considered to have septic arthritis, osteomyelitis, or diskitis, had positive scans. In only two instances did the roentgenograms show osseous lesions at the time of scanning. Strontium 87m scanning appears to be a very sensitive indicator of infection, whether in bone or joints. A negative scan would appear to rule out the presence of an active infection of bone or joints.
N‐terminal probrain natriuretic peptide (NT‐proBNP) in the emergency diagnosis and in‐hospital monitoring of patients with dyspnoea and ventricular dysfunction
Authors: Antoni Bayés‐Genís, Miquel Santaló‐Bel, Edgar Zapico‐Muñiz, Laura López, Carlos Cotes, Jesús Bellido, Rubén Leta, Pere Casan, Jordi Ordóñez‐Llanos
Journal: European Journal of Heart Failure (2004)