Mixed Anaplastic Small-Cell and Squamous-Cell Carcinoma of the Lung
Authors: HARMAR D. BRERETON
Journal: Annals of Internal Medicine (1978)

Brief Reports1 June 1978Mixed Anaplastic Small-Cell and Squamous-Cell Carcinoma of the LungHARMAR D. BRERETON, M.D., MARY M. MATHEWS, M.D., JOSE COSTA, M.D., C. HARRY KENT, M.D., RALPH E. JOHNSON, M.D.HARMAR D. BRERETON, M.D.Search for more papers by this author, MARY M. MATHEWS, M.D.Search for more papers by this author, JOSE COSTA, M.D.Search for more papers by this author, C. HARRY KENT, M.D.Search for more papers by this author, RALPH E. JOHNSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-6-805 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pleomorphism of lung cancer is well known and the appearance of histologically well and poorly differentiated areas within a tissue specimen, or even the coexistence of multiple discreet histologic subtypes, is not uncommon. The association, however, of small-cell anaplastic and squamous-cell lung cancer has been rarely noted, and we report here a 24% prevalence of this association in an autopsy series.Fifty consecutive previously untreated patients with biopsy-proven small-cell carcinoma of the lung were studied between November 1974 and May 1975. Each diagnostic biopsy contained only small-cell anaplastic elements. All patients were evaluated with sequential chest radiographs, whole lung...References1. JOHNSON R, BRERETON H, and KENT C: Small-cell carcinoma of the lung: attempt to remedy causes of past therapeutic failure. Lancet 2:289-291, 1976 CrossrefMedlineGoogle Scholar2. AZZOPARDI J: Oat-cell carcinoma of the bronchus. J Pathol Bacteriol 78:513-519, 1959 CrossrefMedlineGoogle Scholar3. MATTHEWS M: Problems in morphology and behavior of bronchopulmonary malignant disease, in Lung Cancer, Natural History, Prognosis and Therapy, edited by ISRAEL L, CHAHINIAN AP. London, Academic Press, 1976, pp. 23-62 Google Scholar4. LARSSON S and ZETTERGREN L: Histological typing of lung cancer. Acta Pathol Microbiol Scand [A] 84:529-537, 1976 MedlineGoogle Scholar5. BATES M, LENISON V, HURT R, and SUTTON G: Treatment of oat-cell carcinoma of bronchus by preoperative radiotherapy and surgery. Lancet 1:1134-1135, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARMAR D. BRERETON, M.D.; MARY M. MATHEWS, M.D.; JOSE COSTA, M.D.; C. HARRY KENT, M.D.; RALPH E. JOHNSON, M.D.Affiliations: Radiation Oncology and Pathology Branches National Cancer Institute Bethesda, Maryland Veterans Administration Medical Onocology Branch National Cancer Institute Washington, D.C. 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