Severe Diarrhea Controlled by Gamma Globulin in a Patient with Agammaglobulinemia, Amyloidosis, and Thymoma
Authors: HAROLD O. CONN
Journal: Annals of Internal Medicine (1966)

Case Studies1 September 1966Severe Diarrhea Controlled by Gamma Globulin in a Patient with Agammaglobulinemia, Amyloidosis, and ThymomaHAROLD O. CONN, M.D., RICHARD QUINTILIANI, M.D.HAROLD O. CONN, M.D.Search for more papers by this author, RICHARD QUINTILIANI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-528 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe description of agammaglobulinemia by Bruton (1) in 1952 initiated reports of a variety of hypoagammaglobulinemic syndromes and stimulated an enormous amount of research in infectious disease and immunology. Among the clinical variants of hypogammaglobulinemia reported were sprue-like syndromes, anemias of diverse type, and a high prevalence of thymoma. The present report concerns a patient with adult-onset, "acquired" hypogammaglobulinemia who had severe diarrhea which was controlled by the administration of gamma globulin. In addition, amyloidosis and a thymoma were found at autopsy. The purpose of this paper is to define possible relationships among these abnormalities by reviewing the previously reported...References1. BRUTON OC: Agammaglobulinemia. Pediatrics 9: 722, 1952. MedlineGoogle Scholar2. GITLIN D: The hypogammaglobulinemias. DM May, 1962, p. 1. Google Scholar3. CERFCOHEN-SOLALCATTAN MJR: Les hypogammaglobulinémies de l'adulte Presumées Idiopathiques. Le Sang 29: 177, 1958. MedlineGoogle Scholar4. SANFORDFAVOURTRIBEMAN JPCBMS: Absence of serum gamma globulins in an adult. New Eng. J. Med. 250: 1027, 1954. CrossrefMedlineGoogle Scholar5. ROHNBEHNKEBOND RJRHWH: Acquired hypogammaglobulinemia with hypersplenism. A case report. Amer. J. Med. Sci. 229: 406, 1955. CrossrefMedlineGoogle Scholar6. 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