Various Forms of Life in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Authors: Gary S. Hoffman, Carol A. Langford
Journal: Annals of Internal Medicine (2006)

Letters7 March 2006Various Forms of Life in Antineutrophil Cytoplasmic Antibody–Associated VasculitisGary S. Hoffman, MD, MS and Carol A. Langford, MD, MHSGary S. Hoffman, MD, MSFrom the Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this author and Carol A. Langford, MD, MHSFrom the Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-5-200603070-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Hogan and colleagues have restated their belief that the 4 diseases included in their study under the rubric of “ANCA vasculitis” are “phenotypic variants of a single entity, small-vessel vasculitis.” This assertion ignores abundant evidence of important differences among these diseases that influence presentation, complications, selection of treatment strategies, and outcomes.These disease entities have unique clinical differences. Consider, for example, the patient with Wegener granulomatosis who presents with chronic ear, nose, throat, or tracheal damage, none of which are complications of microscopic polyangiitis or renal-limited pauci-immune glomerulonephritis and rarely emerge in the context of the Churg–Strauss syndrome. ...References1. De Groot K, Rasmussen N, Bacon PA, Tervaert JW, Feighery C, Gregorini G, et al. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2005;52:2461-9. [PMID: 16052573] CrossrefMedlineGoogle Scholar2. Jayne D, Rasmussen N, Andrassy K, Bacon P, Tervaert JW, Dadoniené J, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med. 2003;349:36-44. [PMID: 12840090] CrossrefMedlineGoogle Scholar3. Sanders JS, Slot MC, Stegeman CA. Maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies [Letter]. N Engl J Med. 2003;349:2072-3; author reply 2072-3. [PMID: 14627795] CrossrefMedlineGoogle Scholar4. Hoffman GS, Kerr GS, Leavitt RY, Hallahan CW, Lebovics RS, Travis WD, et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116:488-98. [PMID: 1739240] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the Cleveland Clinic Foundation, Cleveland, OH 44195.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAre There Different Forms of Life in the Antineutrophil Cytoplasmic Antibody Universe? Gary S. Hoffman and Carol A. Langford Predictors of Relapse and Treatment Resistance in Antineutrophil Cytoplasmic Antibody–Associated Small-Vessel Vasculitis Susan L. Hogan , Ronald J. Falk , Hyunsook Chin , Jianwen Cai , Caroline E. Jennette , J. Charles Jennette , and Patrick H. Nachman Antineutrophil Cytoplasmic Antibodies and the Churg–Strauss Syndrome Régis Sablé-Fourtassou , Pascal Cohen , Alfred Mahr , Christian Pagnoux , Luc Mouthon , David Jayne , Daniel Blockmans , Jean-François Cordier , Philippe Delaval , Xavier Puechal , Dominique Lauque , Jean-François Viallard , Abdelkader Zoulim , Loïc Guillevin , and Various Forms of Life in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Susan L. Hogan , Ronald J. Falk , Patrick H. Nachman , and J. Charles Jennette Metrics Cited ByCurrent World Literature 7 March 2006Volume 144, Issue 5Page: 378-379KeywordsInflammatory bowel diseaseLesionsOtitis mediaPathogenesisPharynxRenal diseasesRheumatoid arthritisStenosisVasculitisWegener granulomatosis ePublished: 7 March 2006 Issue Published: 7 March 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...