tbuckley/cabot-search huggingface dataset:
Effectiveness of a medical surveillance program for the prevention of occupational asthma caused by platinum salts: A nested case-control study
Authors: Rolf Merget, Carmen Caspari, Alexandra Dierkes-Globisch, Rupprecht Kulzer, Rolf Breitstadt, Annegret Kniffka, Paul Degens, Gerhard Schultze-Werninghaus
Journal: Journal of Allergy and Clinical Immunology (2001)
Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group
Authors: Diego Vergani, Fernando Alvarez, Francesco B. Bianchi, Eduardo L.R. Cançado, Ian R. Mackay, Michael P. Manns, Mikio Nishioka, Edward Penner
Journal: Journal of Hepatology (2004)
Local skin depigmentation due to local corticosteroid injection
Authors: A J Richards
Journal: BMJ (1984)

incidence between first and second trimesters (x2=43 p< 0001) followed by an increased incidence in the third trimester (X2=26 p<0001).In view of these differences one wonders to what extent the association between life events and birthweight can be trusted to reflect causal relation.The differences in the incidence of life events are intriguing.A possible explanation is that a reported incidence reflects discomfort during pregnancy in terms of changing behaviour or changing the perception or reporting of life events.The discomfort of the first and third trimesters being contrasted by the relative well being of the second.To consider Dr Newton and Miss Hunt's data in this way would probably be more productive than in terms of the "stress" hypothesis.Demonstrable behavioural and psychological changes in pregnancy are of much broader interest and implication than the remote possi- bility of stress.
Intracellular CD24 Inhibits Cell Invasion by Posttranscriptional Regulation of BART through Interaction with G3BP
Authors: Keisuke Taniuchi, Isao Nishimori, Michael A. Hollingsworth
Journal: Cancer Research (2011)

We report a novel function for the CD24 molecule in pancreatic cancer cells. Intracellular CD24 is associated with stress granules that contain specific mRNAs and RNA-binding proteins that regulate mRNA stability and translation. Intracellular CD24 in stress granules is associated with G3BP, a phosphorylation-dependent endoribonuclease. The vesicles in which the CD24/G3BP complex localizes are transported toward cell protrusions in migrating cells. We show that G3BP binds to and degrades Binder of Arl Two (BART) mRNA. BART was originally identified as a binding partner of ARL2, a small G-protein implicated as a regulator of microtubule dynamics and folding. Intracellular CD24 inhibits the specific endoribonuclease activity of G3BP toward BART mRNA in stress granules. We show that knockdown of CD24 increases retroperitoneal invasion and liver metastasis of pancreatic cancer cells in an orthotopic xenograft model, and that BART also prevents retroperitoneal invasion and liver metastasis of pancreatic cancer cells. Our results imply that surface CD24 may play a role in the inhibition of cell invasion and metastasis, and that intracellular CD24 inhibits invasiveness and metastasis through its influence on the posttranscriptional regulation of BART mRNA levels via G3BP RNase activity.
Review: Fluid resuscitation with colloids does not reduce mortality more than crystalloids in critically ill patients
Authors: Shirin Shafazand
Journal: Annals of Internal Medicine (2008)

ACP Journal Club20 May 2008Review: Fluid resuscitation with colloids does not reduce mortality more than crystalloids in critically ill patientsShirin Shafazand, MD, MS, FCCP, D.ABSM, FRCP(C)Shirin Shafazand, MD, MS, FCCP, D.ABSM, FRCP(C)University of Miami, Miami, Florida, USA (S.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-10-200805200-02009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPerel P, Roberts I. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2007;(4):CD000567. https://pubmed.ncbi.nlm.nih.gov/17943746Clinical Impact RatingsEmergency Med: Hospitalists: Critical Care: Reference1 Finfer S, Bellomo R, Boyce N, for the SAFE Study Investigators. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350:2247-56. [PMID: 15163774] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Miami, Miami, Florida, USA (S.S.)This article was published at Annals.org on 6 May 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 May 2008Volume 148, Issue 10Page: JC3-9KeywordsAlbuminsClinical trialsDextranIsotonicityMortalityPlasma proteinsPopulation statisticsResuscitationSepsisStarches ePublished: 20 May 2008 Issue Published: 20 May 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice.
Authors: Daniel Zalko, Ana M Soto, Laurence Dolo, Céline Dorio, Estelle Rathahao, Laurent Debrauwer, Robert Faure, Jean-Pierre Cravedi
Journal: Environmental Health Perspectives (2002)

We investigated the metabolic fate of a low dose (25 micro g/kg) of bisphenol A [2,2-bis(4-hydroxy-phenyl)propane] (BPA) injected subcutaneously in CD1 pregnant mice using a tritium-labeled molecule. Analytic methods were developed to allow a radio-chromatographic profiling of BPA residues in excreta and tissues, as well as in mothers' reproductive tracts and fetuses, that contained more than 4% of the administered radioactivity. BPA was extensively metabolized by CD1 mice. Identified metabolite structures included the glucuronic acid conjugate of BPA, several double conjugates, and conjugated methoxylated compounds, demonstrating the formation of potentially reactive intermediates. Fetal radioactivity was associated with unchanged BPA, BPA glucuronide, and a disaccharide conjugate. The latter structure, as well as that of a dehydrated glucuronide conjugate of BPA (a major metabolite isolated from the digestive tract), showed that BPA metabolic routes were far more complex than previously thought. The estrogenicity of the metabolites that were identified but not tested for hormonal activity cannot be ruled out; however, in general, conjugated BPA metabolites have significantly lower potency than that of the parent compound. Thus, these data suggest the parental compound is responsible for the estrogenic effects observed in fetuses exposed to BPA during gestation in this mammalian model.
Kaposiform hemangioendothelioma without Kasabach-Merritt phenomenon
Authors: Alla Gruman, Marilyn G. Liang, John B. Mulliken, Steven J. Fishman, Patricia E. Burrows, Harry P.W. Kozakewich, Francine Blei, Ilona J. Frieden
Journal: Journal of the American Academy of Dermatology (2005)
Relevance of Exocytotic Glutamate Release from Retinal Glia
Authors: Michal Slezak, Antje Grosche, Aurore Niemiec, Naoyuki Tanimoto, Thomas Pannicke, Thomas A. Münch, Britni Crocker, Philippe Isope, Wolfgang Härtig, Susanne C. Beck, Gesine Huber, Geraldine Ferracci, Martine Perraut, Michael Reber, Monique Miehe, Valérie Demais, Christian Lévêque, Daniel Metzger, Klaudia Szklarczyk, Ryszard Przewlocki, Mathias W. Seeliger, Dominique Sage-Ciocca, Johannes Hirrlinger, Andreas Reichenbach, Sophie Reibel, Frank W. Pfrieger
Journal: Neuron (2012)
Palliative Care at US Cancer Centers
Authors: John Weems
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophils — Nominated but Not Elected
Authors: Max Samter
Journal: New England Journal of Medicine (1980)

Resolved, that we agree with Walter B. Cannon's dictum that "What happens in our bodies is directed toward a useful end," what, then, is the useful end of the eosinophil?Certainly, the eosinophil is a spectacular cell. How is it possible that a cell that is so ubiquitous, so beautiful when stained, has been able to hide its purposes for more than 100 years? The predicament has been portrayed in Arthus' delightful preface to his De l'Anaphylaxie à l'Immunité: "Oh, of course, at the end of a day of experimental work during which I found facts that seemed interesting . . .
Dichotomy in the tissue origin of schistosome acquired class I and class II major histocompatibility complex antigens.
Authors: A Sher, D L Sacks, A J Simpson, A Singer
Journal: The Journal of Experimental Medicine (1984)

Schistosoma mansoni schistosomula recovered from the lungs of mice have previously been shown to express host-derived class I and class II major histocompatibility complex (MHC) antigens. To investigate the tissue origin of parasite-acquired MHC products, lung-stage schistosomula were obtained from a series of parent leads to F1 and F1 leads to parent bone marrow chimeras and the parasites typed by immunofluorescence for the presence of haplotype-specific K region and I region MHC determinants. The results of these experiments indicated that, despite their intravascular residence in the host, schistosomula derive all of their class I antigen from a nonhemapoietic tissue source. In contrast, the class II antigens expressed on the surface of schistosomula were found to originate from bone marrow-derived donor cells. These results support the hypothesis that MHC product acquisition by schistosomes involves selective and specific interactions with host tissue and, in the case of class I antigens, suggest that the endothelium may be a major site of host molecule uptake for the parasite.
Variability in Biomarkers of Arsenic Exposure and Metabolism in Adults over Time
Authors: Molly L. Kile, Elaine Hoffman, Yu-Mei Hsueh, Sakila Afroz, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mahiuddin, Louise Ryan, David C. Christiani
Journal: Environmental Health Perspectives (2008)

Urinary arsenic metabolites (UAs) are used as biomarkers of exposure and metabolism.To characterize inter- and intraindividual variability in UAs in healthy individuals.In a longitudinal study conducted in Bangladesh, we collected water and spot urine samples from 196 participants every 3 months for 2 years. Water arsenic (As) was measured by inductively coupled plasma-mass spectrometry and urinary As [arsenite, arsenate, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA)] were detected using high-performance liquid chromatography-hydride-generated atomic absorption spectrometry. We used linear mixed-effects models to compute variance components and evaluate the association between UAs and selected factors.The concentrations of UAs were fairly reproducible within individuals, with intraclass correlation coefficients (ICCs) of 0.41, 0.35, 0.47, and 0.49 for inorganic As (InAs), MMA, DMA, and total urinary As (TUA). However, when expressed as a ratio, the percent InAs (%InAs), %MMA, and %DMA were poorly reproducible within individuals, with ICCs of 0.16, 0.16, and 0.17, respectively. Arsenic metabolism was significantly associated with sex, exposure, age, smoking, chewing betel nut, urinary creatinine, and season. Specificity and sensitivity analyses showed that a single urine sample adequately classified a participant's urinary As profile as high or low, but TUA had only moderate specificity for correctly classifying drinking water exposures.Epidemiologic studies should use both urinary As concentrations and the relative proportion of UAs to minimize measurement error and to facilitate interpretation of factors that influence As metabolism.
Endoscopic variceal pressure measurements: response to isosorbide dinitrate.
Authors: J Dawson, P Gertsch, F Mosimann, R West, E Elias
Journal: Gut (1985)

An endoscopic pressure sensor has been evaluated in the measurement of oesophageal variceal pressure and its response to drug ingestion. The variceal pressure showed a highly significant correlation with the splenic pulp pressure (r = 0.97) in six patients with liver disease of diverse aetiology and with hepatic venous wedge pressure (r = 0.92) in eight alcoholic cirrhotic men. Intraduodenal infusion of isosorbide dinitrate in the cirrhotics produced no change in wedge pressure or endoscopic variceal pressure despite profound falls in arterial systolic pressure. Thus isosorbide dinitrate appears to be of no value in treating portal hypertension. This study establishes the endoscopic pressure sensor as a valuable tool in screening drugs in this condition.
Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling
Authors: Yoshikazu Nakaoka, Keigo Nishida, Masahiro Narimatsu, Atsunori Kamiya, Takashi Minami, Hirofumi Sawa, Katsuya Okawa, Yasushi Fujio, Tatsuya Koyama, Makiko Maeda, Manami Sone, Satoru Yamasaki, Yuji Arai, Gou Young Koh, Tatsuhiko Kodama, Hisao Hirota, Kinya Otsu, Toshio Hirano, Naoki Mochizuki
Journal: Journal of Clinical Investigation (2007)

Grb2-associated binder (Gab) family of scaffolding adaptor proteins coordinate signaling cascades downstream of growth factor and cytokine receptors. In the heart, among EGF family members, neuregulin-1beta (NRG-1beta, a paracrine factor produced from endothelium) induced remarkable tyrosine phosphorylation of Gab1 and Gab2 via erythroblastic leukemia viral oncogene (ErbB) receptors. We examined the role of Gab family proteins in NRG-1beta/ErbB-mediated signal in the heart by creating cardiomyocyte-specific Gab1/Gab2 double knockout mice (DKO mice). Although DKO mice were viable, they exhibited marked ventricular dilatation and reduced contractility with aging. DKO mice showed high mortality after birth because of heart failure. In addition, we noticed remarkable endocardial fibroelastosis and increase of abnormally dilated vessels in the ventricles of DKO mice. NRG-1beta induced activation of both ERK and AKT in the hearts of control mice but not in those of DKO mice. Using DNA microarray analysis, we found that stimulation with NRG-1beta upregulated expression of an endothelium-stabilizing factor, angiopoietin 1, in the hearts of control mice but not in those of DKO mice, which accounted for the pathological abnormalities in the DKO hearts. Taken together, our observations indicated that in the NRG-1beta/ErbB signaling, Gab1 and Gab2 of the myocardium are essential for both maintenance of myocardial function and stabilization of cardiac capillary and endocardial endothelium in the postnatal heart.
Human Papillomavirus Type 16 DNA in Periungual Squamous Cell Carcinomas
Authors: Ronald L. Moy
Journal: JAMA (1989)

Ten squamous cell carcinomas (in situ or invasive) of the fingernail region were analyzed for the presence of DNA sequences homologous to human papillomavirus (HPV) by dot blot hybridization. In most patients, the lesions were verrucae of long-term duration that were refractory to conventional treatment methods. Eight of the lesions contained HPV DNA sequences, and in six of these the sequences were related to HPV 16 as deduced from low-stringency nucleic acid hybridization followed by low- and high-stringency washes. Furthermore, the restriction endonuclease digestion pattern of DNA isolated from four of these lesions was diagnostic of episomal HPV 16. The high-frequency association of HPV 16 with periungual squamous cell carcinoma is similar to that reported for HPV 16 with squamous cell carcinomas on mucous membranes at other sites, notably the genital tract. Our findings suggest that HPV 16 may play an important role in the development of squamous cell carcinomas of the finger, most notably those lesions that are chronic and located in the periungual area.
Academic medicine: who is it for?
Authors: Hanamaraddi T Gangal
Journal: BMJ (2005)

Editor—The medical profession and society are at loggerheads because they mistrust each other as a result of increasing adverse effects from the concepts, drugs, and amenities advocated and promoted by business oriented biotechnologies and industry; these promotions have been blindly used and accepted by the serving profession for various reasons, including financial gains. This has led to the BMJ's long overdue campaign to promote academic medicine.1 It needs the participation of honest and knowledgeable people to regain trust.​trust.




Figure 1




The general media have a significant role. Now degraded moral values that have led to an unhealthy link between business and the serving profession to convert laboratory results into clinical utility have legal implications. This has happened at the cost of academic medicine and its advocates because of the serving profession, society, and governments the world over.2 Developments are few but are highly glorified, resulting in many rude shocks, and they have alerted even the serving profession to realise the need to understand and participate in the development of a subject in order to be competent and competitive in an alert and demanding society.

Many participate in academic medicine as a means for future dependable clinical research, as indicated by the Association of American Medical Colleges. The benefits are enormous. This is echoed in the theme issue on academic medicine.3,4 High tech oriented remedies cannot provide the needed benefits to society even at referral hospitals in the best developed and financed countries, thus making them search for simpler clinically tried and dependable remedies to be provided at primary healthcare centres.5

In addition to all the above, academic medicine will enable the profession to regain its lost moral values and dignity. It will pave the way for society to not only depend on the profession but also not demand from it alone.
Low-Dose Penicillin for Gonococcal Arthritis
Authors: David E. Trentham, John W. McCravey, Alfonse T. Masi
Journal: JAMA (1976)

Sixty-three patients with gonococcal arthritis completed a double-blind randomized penicillin therapy trial comparing a low dose regimen (procaine penicillin G, 600,000 units intramuscularly, given every 12 hours for up to ten days) with a high dose (the same procaine penicillin regimen and intravenous aqueous penicillin G, 10 million units daily, for the first three days). Pretherapy features were similar in the 36 patients allocated to low-dose vs the 27 to high-dose therapy. All patients had definite improvement within 48 hours of the initiation of either regimen. No therapeutic response variable studied differed significantly between the groups. Thus, no additional therapeutic benefit accrued from the high doses of penicillin. The absence of complications or failures in either treatment group indicate that gonococcal arthritis is ordinarily quite responsive to low doses of penicillin given intramuscularly, and that massive intravenous therapy is unnecessary.
THE FUNCTION OF THE KIDNEYS.
Authors: GEO. W. WEBSTER
Journal: JAMA (1893)

<i>Origin of Urea and Uric Acid</i>.—Some of the recent editorials on this subject would lead us to infer that the function of the kidneys is not well understood, or that there is a wide difference of opinion regarding it. Merck's Bulletin, Dec. 18, 1892, says editorially: " Through the agency of the epithelial cells lining the uriniferous tubules the urea, uric acid and creatine are normally formed and discharged," etc. Again: " The function of the glomeruli is comparatively simple, being entirely under the control of the vasomotor system." Indeed, such statements as the foregoing are comparatively common, but ought not to go unchallenged. A knowledge of physiology should precede and serve as a basis for rational therapeutics, and the more thorough and more nearly correct the former, the more scientific and satisfactory will be the latter. Instead of calling the kidneys secreting organs and the urine an excretion, it
A Prospective Comparison of Selective and Universal Electronic Fetal Monitoring in 34,995 Pregnancies
Authors: Kenneth J. Leveno, F. Gary Cunningham, Sheryl Nelson, Micki Roark, M. Lynne Williams, David Guzick, Sharon Dowling, Charles R. Rosenfeld, Ann Buckley
Journal: New England Journal of Medicine (1986)

Abstract We investigated the effects of using intrapartum electronic fetal monitoring in all pregnancies, as compared with using it only in cases in which the fetus is judged to be at high risk. Predominant risk factors included oxytocin stimulation of labor, dysfunctional labor, abnormal fetal heart rate, or meconium-stained amniotic fluid. This prospective alternate-month clinical trial took place over a 36-month period during which 34,995 women gave birth. In alternate months, either 7 (for "selective monitoring") or 19 (for "universal monitoring") fetal monitors were made available in the labor and delivery unit. During the "selective" months, 6420 of 17,409 women (37 percent) were electronically monitored, as compared with 13,956 of 17,586 women (79 percent) during the "universal months." Universal monitoring was associated with a small but significant increase in the incidence of delivery by cesarean section because of fetal distress, but perinatal outcomes as assessed by intrapartum stillbirths, low Apgar scores, a need for assisted ventilation of the newborn, admission to the intensive care nursery, or neonatal seizures were not significantly different. We conclude that not all pregnancies, and particularly not those considered at low risk of perinatal complications, need continuous electronic fetal monitoring during labor. (N Engl J Med 1986; 315:615–9.)
TCT- 402 Renal Norepinephrine Reduction Following Radiofrequency Renal Denervation Correlates with Extent of Nerve Ablation: Roles of Ablation Areas, Anatomy, and Number of Treatments
Authors: Abraham R. Tzafriri, Felix Mahfoud, John Keating, Gee Wong, Anna-Maria Spognardi, James Stanley, Debby Highsmith, Patrick O'Fallon, Elazer Edelman
Journal: Journal of the American College of Cardiology (2014)
TCT-166 Association between leg wound site and prognosis of hemodialysis patients with critical limb ischemia after isolated infrapopliteal balloon angioplasty
Authors: Masatsugu Nakano, Keisuke Hirano, Osamu Iida, Yasutaka Yamauchi, Yoshimitsu Soga, Daizo Kawasaki, Kenji Suzuki, Terutoshi Yamaoka, Junichi Tazaki, Nobuhiro Suematsu, Yoshiaki Shintani, Yusuke Miyashita
Journal: Journal of the American College of Cardiology (2012)