Hormonal and Biochemical Studies in a Diabetic Family
Authors: MARVIN E. LEVIN
Journal: Annals of Internal Medicine (1967)

Article1 January 1967Hormonal and Biochemical Studies in a Diabetic FamilyMARVIN E. LEVIN, M.D., F.A.C.P., LILLIAN RECANT, M.D.MARVIN E. LEVIN, M.D., F.A.C.P.Search for more papers by this author, LILLIAN RECANT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-1-69 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe prediabetic period is that interval between conception and the time the genetically predisposed diabetic develops chemical or clinical evidence of abnormal carbohydrate metabolism. This is not a benign interval. Evidence is rapidly accumulating that during this period the structural changes of microangiopathy are already taking place. Despite this early occurrence of microangiopathy, significant degrees of functional organ impairment in diabetes are rarely seen unless the carbohydrate metabolism has become abnormal. From this point of view, the approach to the problem is twofold: to find the prediabetic, and to find the proper therapy for this stage of the disease so...References1. WILKERSON HL: Diagnosis: oral glucose tolerance tests in diabetes mellitus, in Diagnosis and Treatment, edited by DANOWSKI, T. S. American Diabetes Association, New York, 1964, p. 31. Google Scholar2. MORGANLAZAROW CRAI: Immunoassay of insulin: two antibody system. Plasma insulin levels of normal, subdiabetic, and diabetic rats. Diabetes 12: 115, 1963. CrossrefGoogle Scholar3. SCHALCHPARKER DSML: A sensitive double antibody immunoassay for human growth hormone in plasma. Nature (London) 203: 1141, 1964. CrossrefMedlineGoogle Scholar4. DOLE VP: A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J. Clin. Invest. 35: 150, 1956. CrossrefMedlineGoogle Scholar5. DUNCOMBE WG: The colorimetric microdetermination of long-chain fatty acids. Biochem. J. 88: 7, 1963. 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CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARVIN E. LEVIN, M.D., F.A.C.P.; LILLIAN RECANT, M.D.Affiliations: St. Louis, MissouriFrom the Department of Medicine, Nutrition Research Laboratories, Washington University School of Medicine, St. Louis, Mo.This study was supported by grant AM 06305, National Institutes of Health, Bethesda, Md., and research grant FR-36, Division of Research Facilities and Resources, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Marvin E. Levin, M.D., Washington University School of Medicine, Department of Preventive Medicine, 660 South Euclid Ave., St. Louis, Mo. 63110. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe role of growth hormone in the pathogenesis of diabetes mellitus in childhoodInheritance in Diabetes MellitusRole of synalbumin insulin antagonist in pathogenesis of diabetes mellitusThe response of serum glucose, free fatty acid and immunoreactive insulin to oral glucose and intravenous tolbutamide in normal, potentially diabetic and diabetic subjectsGrowth hormone in insulin-treated diabetes mellitusABNORMAL GROWTH HORMONE RESPONSE TO INGESTION OF GLUCOSE IN JUVENILE DIABETICSPLASMA GROWTH HORMONE DURING GLUCOSE LOADING IN DIABETES OR OBESITY 1 January 1967Volume 66, Issue 1Page: 69-76KeywordsBlood plasmaCarbohydrate metabolismGrowth hormoneInsulinMedical servicesNutritionOverweightResearch facilitiesResearch grantsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 January 1967 PDF downloadLoading ...