tbuckley/cabot-search huggingface dataset:
The glycoprotein isolated from vesicular stomatitis virus is mitogenic for mouse B lymphocytes.
Authors: G Goodman-Snitkoff, R J Mannino, J J McSharry
Journal: The Journal of Experimental Medicine (1981)

The glycoprotein (G protein) of VSV was purified from the intact virion by Triton X-100 extraction. The isolated G protein has been shown to be a T cell-independent, B lymphocyte mitogen and polyclonal activator. Neither G protein nor the intact virion are stimulatory for murine T lymphocytes. The greater the density of G protein in lipid vesicles or the degree of aggregation of isolated G protein, the more highly stimulatory it is for murine splenocytes. As G protein is spread out in artificial vesicles, it becomes less mitogenic. It is probable that other viral components are also stimulatory since the Triton-insoluble pellet and VSV from which the G protein has been enzymatically removed retain mitogenic activity. To out knowledge, this is the first time a purified viral component has been demonstrated to be lymphocyte mitogen.
Chronic herpes simplex virus type I glossitis in an immunocompromised man
Authors: None NIKKELS, None PIÉRARD
Journal: British Journal of Dermatology (1999)

Herpes simplex virus (HSV) type 1 (HSV-1) infection of the tongue commonly accompanies acute primary herpetic gingivostomatitis. However, recurrent infection of the tongue is exceptional and is restricted to immunocompromised individuals. A 57-year-old man with corticosteroid-dependent chronic obstructive pulmonary disease and sciatica presented with a chronic median glossitis due to HSV-1. The main clinical and histological feature was massive necrosis of the entire mucosa. Immunohistochemistry demonstrated a considerable amount of HSV gB, gC and gD envelope glycoproteins dispersed in the chorion. In contrast, HSV-1 DNA was detected only in a limited number of epithelial cells using in situ hybridization. The extent of necrosis and the pattern of viral DNA and envelope protein distribution represent unique features of median herpetic glossitis, which are not found in more common types of HSV infection.
Clinical Alcohol Hypoglycemia and Isolated Adrenocorticotrophic Hormone Deficiency
Authors: PAUL STEER
Journal: Annals of Internal Medicine (1969)

A 43-year-old man is described who fulfills the usual criteria for both alcohol hypoglycemia and isolated adrenocorticotrophic hormone (ACTH) deficiency. This is the fifth such patient reported. However, this patient was unique in that the ACTH deficiency seemed limited to the cortisol feedback whereas the response to hypoglycemia was normal. The question arises whether there was truly an aberration in the cortisol servomechanism or whether the diagnostic criterion (metyrapone test) is unsatisfactory. In any event maintenance glucocorticoid therapy resulted in remarkable clinical benefit.
Where now for the NHS reforms?
Authors: C Ham
Journal: BMJ (1994)

Where now for the NHS reforms?Making them up as they go along Last week saw the publication of a series of reports on the role of the Department of Health and the management of the new NHS (see p 357).'These reports were commissioned in the light of the functions and manpower review and the decision to abolish regional health authorities and merge district health authorities and family health services authorities.2The result of ministerial deliberations and Treasury intervention will be a sub- stantial reduction in the number of civil servants in the Department of Health.There will also be tight controls over the number of staff employed in the new regional offices of the NHS Executive and a move to accelerate joint commissioning between district health authorities and family health services authorities.This all adds up to a further period of major structural change as the government seeks to get the organisation right.While many of the planned changes are sensible in their own right, taken together they will undoubtedly divert scarce managerial time and attention away from the real issues facing the health services.These are less to do with structure and management than with the future direction of the NHS itself.As things stand, there is no coherent strategy guiding the development of the NHS and there is a suspicion that the current occupants of Richmond House are not much interested in developing one.Tactics have come to dominate strategy, and ministers have seemed
Desferrioxamine related maculopathy: A case report
Authors: Anita Arora, Siobhan Wren, Kevin Gregory Evans
Journal: American Journal of Hematology (2004)

Abstract Desferrioxamine is used for the treatment of chronic iron overload, acute iron poisoning, and certain anaemias. Ocular toxicity secondary to prolonged treatment with desferrioxamine may result in night blindness, visual field constriction, cataract, pigmentary retinopathy and optic neuropathy. To avoid such complications an ophthalmic screening has been suggested for patients taking desferrioxamine. We report an 81‐year‐old patient who developed irreversible ocular toxicity despite undergoing ophthalmic screening. Am. J. Hematol. 76:386–388, 2004. © 2004 Wiley‐Liss, Inc.
Maternal Cow's Milk Avoidance During Lactation Suppresses IgA Levels in Breast Milk and Serum IgG Levels in Infants
Authors: K.M. Jarvinen, M.S. Seppo, A. James, A. Tsuang, M.C. Berin, H.A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2012)
Regulation of gastric emptying in humans by cholecystokinin.
Authors: R A Liddle, E T Morita, C K Conrad, J A Williams
Journal: Journal of Clinical Investigation (1986)

In the present study we used a bioassay system for measuring plasma cholecystokinin (CCK) to evaluate whether CCK has a physiologic role in regulating gastric emptying in humans. Plasma CCK levels and gastric emptying after ingestion of a mixed liquid meal were determined in five normal male volunteers. Fasting CCK levels averaged 0.8 +/- 0.1 pM and increased to 6.5 +/- 1.0 pM within 10 min of drinking the mixed meal. CCK levels remained elevated for up to 90 min. Gastric emptying after a meal was slow; at the end of the 90 min 68% of the original volume remained in the stomach. The rate of gastric emptying of water was then measured in the same individuals with a simultaneous infusion of either saline, or one of two doses of CCK (12 pmol/kg per h and 24 pmol/kg per h). With the saline infusion, plasma CCK levels did not increase above basal and gastric contents emptied rapidly. At the end of 90 min only 7% of the original volume remained in the stomach. The lower dose of CCK resulted in a plasma level of 3.4 pM which both reproduced the average postprandial plasma level and caused a significant delay in gastric emptying. The higher dose of CCK achieved plasma levels of 8 pM and resulted in a delay in gastric emptying that was similar to that seen with the mixed meal. Since exogenous CCK at concentrations which occur postprandially delays gastric emptying, we conclude that CCK is a physiologic regulator of gastric emptying.
Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
Authors: Christoph Kleinschnitz, Nicholas Schwab, Peter Kraft, Ina Hagedorn, Angela Dreykluft, Tobias Schwarz, Madeleine Austinat, Bernhard Nieswandt, Heinz Wiendl, Guido Stoll
Journal: Blood (2010)
Eye injuries caused by elasticated straps
Authors: R H Gray, M J Menage, S D Cook, J Harcourt
Journal: BMJ (1988)

Cardiac transplantation in severely ill patients requiring intensive support in hospital An error occurred in this paper by Dr David Mulcahy and others (19 March, p 817).In the second paragraph of the abstract the term renal transplantation was incorrect; the sentence should read, "Provided that surgery can be performed before renal failure has progressed such that renal dialysis is necessary...." Pure trigeminal motor neuropathy
Hepatic tissue oxygenation as a predictive indicator of ischemia-reperfusion liver injury
Authors: Moritaka Goto, Sunao Kawano, Harumasa Yoshihara, Yoshiyuki Takei, Taizo Hijioka, Hiroyuki Fukui, Takashi Matsunaga, Masahide Oshita, Toru Kashiwagi, Hideyuki Fusamoto, Takenobu Kamada, Nobuhiro Sato
Journal: Hepatology (1992)

The purpose of this study was to determine whether hepatic tissue oxygenation after ischemia-reperfusion procedures is an indicator for later liver injury. Partial ischemia in the liver was induced by ligating the left pedicles. Rats were divided into two groups according to duration of ischemia: group A (30-min ischemia) and group B (60-min ischemia). Indices of blood oxygenation and blood volume in regional hepatic tissue, serum ALT levels and histological appearance of livers were evaluated. Twenty-four hours after ischemia and reflow, all rats in group A were alive, whereas only 67% survived in group B. Blood-oxygenation index and blood-volume index in group A rats rebounded quickly after reperfusion. In group B, blood-oxygenation index and blood-volume index remained significantly lower than in group A after reperfusion. Serum ALT levels at 60 and 120 min after reperfusion in group B were significantly higher than those in group A. Blood-oxygenation index measured at 5 and 60 min of reperfusion showed significant correlation with serum ALT levels at 120 min of reperfusion. When the percentage recovery of blood-oxygenation index at 5 and 60 min after reperfusion was more than 75%, all rats survived. No obvious signs of hepatocellular degeneration were observed histologically 5 min after reperfusion; however, substantial hepatocellular degeneration had occurred at 120 min of reperfusion in groups A and B. These data indicate that a decline in hepatic tissue oxygenation during the early phase of reperfusion (even when no obvious hepatocellular degeneration has been observed) can be a predictor of subsequent liver injury and prognosis.
Long-term Luminal Renarrowing After Successful Elective Coronary Angioplasty of Total Occlusions
Authors: Andonis G. Violaris, Rein Melkert, Patrick W. Serruys
Journal: Circulation (1995)

The long-term angiographic outcome after successful dilatation of coronary occlusions remains unclear. The objective of this study was to examine long-term restenosis after successful balloon dilatation of coronary occlusions at a predetermined time interval with quantitative angiography and compare this with a control population of stenoses.The study population comprised 2950 patients (3583 lesions) prospectively enrolled in and successfully completing four major restenosis trials (86% quantitative angiographic follow-up). Cineangiographic films were processed and analyzed at a central core laboratory with the use of an automated interpolated edge detection technique. The study population comprised 266 occlusions (7%) defined as total when there was absent anterograde filling beyond the lesion (109 lesions) and functional (157 lesions) when faint, late anterograde opacification of the distal segment was seen in the absence of a discernible luminal continuity; 3317 lesions were defined as stenoses (93%). Restenosis was significantly higher after successful dilatation of occlusions than of stenoses. With the categorical (> 50% diameter stenosis at follow-up) approach, the restenosis rate was 44.7% in occlusions compared with 34.0% in stenoses (P < .001; relative risk, 1.575; CI, 1.224 to 2.027). Similarly, the absolute loss (defined as the change in minimal lumen diameter between post coronary angioplasty and follow-up; in millimeters, mean +/- SD) (0.43 +/- 0.68) in occlusions was significantly higher than in stenoses (0.31 +/- 0.51, P < .001), as was the relative loss, defined as the change in minimal lumen diameter between postangioplasty and follow-up, adjusted for the vessel size (0.17 +/- 0.28 versus 0.12 +/- 0.20, P < .001). The higher restenosis rate in the occlusions group was due predominantly to an increased number of occlusions at follow-up angiography in this group (19.2% compared with 5.0% for stenoses, P < .001). Within the occlusions group, there were no significant differences in long-term outcome between total and functional occlusions (restenosis rate, 45.0% versus 44.6%; reocclusion rate, 23.9% versus 15.9%; absolute loss, 0.53 +/- 0.69 versus 0.36 +/- 0.67; relative loss, 0.21 +/- 0.28 versus 0.15 +/- 0.28; P = NS).These results indicate that successfully dilated coronary occlusions, both total and functional, have a higher rate of angiographic restenosis at 6 months than stenoses. This is due chiefly to a higher rate of occlusion at follow-up angiography in this group of lesions. Measures aimed at reducing restenosis after successful dilatation of coronary occlusion should be focused in this direction.
Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort
Authors: Jane E. Salmon, Cara Heuser, Michael Triebwasser, M. Kathryn Liszewski, David Kavanagh, Lubka Roumenina, D. Ware Branch, Tim Goodship, Veronique Fremeaux-Bacchi, John P. Atkinson
Journal: PLoS Medicine (2011)

Jane Salmon and colleagues studied 250 pregnant patients with SLE and/or antiphospholipid antibodies and found an association of risk variants in complement regulatory proteins in patients who developed preeclampsia, as well as in preeclampsia patients lacking autoimmune disease.
Oncology and Hematology
Authors: Barbara A. Burtness
Journal: JAMA (1995)

Since the mapping in 1990 of a breast cancer susceptibility gene—dubbed<i>BRACA1</i>—to the long arm of chromosome 17,<sup>1</sup>an intensive effort has been under way to isolate the gene. This gene was predicted to account for a large proportion of breast cancers arising in families with histories of early onset of both breast and ovarian cancers, and some sporadic cases of breast cancer. A strong candidate was announced in the past year.<sup>2</sup>The new gene is very large and contains sequences that suggest that it has DNA binding and translational activity, consistent with function as a transcription factor. Mutations were identified in five of eight kindreds tested; those identified to date are predicted to lead to protein with altered or lost function. In each of the kindreds with early onset of breast cancer, at least one woman carried the gene but survived to the age of 80
Clinical technology specialists
Authors: D. Ben-Zeev, R. Drake, L. Marsch
Journal: BMJ (2015)

Who needs them? We do

We are in the midst of a rapid proliferation of patient facing clinical technologies. More than 50 000 mobile health applications are available for people to download directly onto their mobile devices, and the number grows daily. A range of commercial wearable sensors (such as wristbands, patches, chest monitors) are also appearing to promote healthy lifestyles or to monitor medical conditions in the context of clinical care, strengthening the role of patients in quantified self tracking.1 2 Two way video and texting applications are making different forms of telemedicine increasingly accessible and popular. Every day more and more people look to internet based resources such as chat forums to help them understand their medical conditions and explore treatment options.

In the United States, the Health Information Technology for Economic and Clinical Health (HITECH) Act was signed into law in 2009 to promote and incentivize the broad adoption and meaningful use of health information technology to improve healthcare.3 Apple recently began offering software that culls and centralizes users’ health information as a standard feature of their new operating system …
New Zealand cervical cancer study: could it happen again?
Authors: D. Slater
Journal: BMJ (1988)

surgery for locally recurrent disease, a figure which we would regard as higher than desirable.Though the results of our studies and those of others may lead us to revise our approach in due course, we think that meantime we should continue to explain to our elderly patients that there are two forms of treatment available.One entails immediate surgery, the other a trial of tamoxifen, surgery then being required only if the disease is not controlled, which is likely in less than half of those treated.The choice is theirs.
MHC I–associated peptides preferentially derive from transcripts bearing miRNA response elements
Authors: Diana Paola Granados, Wafaa Yahyaoui, Céline M. Laumont, Tariq Daouda, Tara L. Muratore-Schroeder, Caroline Côté, Jean-Philippe Laverdure, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Journal: Blood (2012)
Music Lessons: What Musicians Can Teach Doctors (and Other Health Professionals)
Authors: Frank Davidoff
Journal: Annals of Internal Medicine (2011)

Medicine is a learned profession, but clinical practice is above all a matter of performance, in the best and deepest sense of the word. Because music is, at its core, a pure distillate of real-time performance, musicians are in an excellent position to teach us about better ways to become and remain expert performers in health care and ways for our teachers and mentors to help us do that. Ten features of the professionalization of musicians offer us lessons on how the clinical practice of medicine might be learned, taught, and performed more effectively.
Stem cell collection in patients with de novo multiple myeloma treated with the combination of bortezomib and dexamethasone before autologous stem cell transplantation according to IFM 2005–01 trial
Authors: P Moreau, C Hulin, G Marit, D Caillot, T Facon, P Lenain, C Berthou, B Pégourié, A M Stoppa, P Casassus, M Michallet, L Benboubker, H Maisonneuve, C Doyen, S Leyvraz, C Mathiot, H Avet-Loiseau, M Attal, J L Harousseau
Journal: Leukemia (2010)
Where are somatosensory representations stored and reactivated?
Authors: Katja Fiehler, Annerose Engel, Frank Rösler
Journal: Behavioral and Brain Sciences (2007)

Abstract The studies cited by Dijkerman &amp; de Haan (D&amp;dH) stress the distinction between perception and action within the somatosensory system but provide little information about memory functions. Recent findings by our group and by others show that the dorsal stream is also activated during short-term memory maintenance and long-term memory retrieval of haptic information. These data complement and extend the proposed model.
Myeloperoxidase, Subclinical Atherosclerosis, and Cardiovascular Disease Events
Authors: Nathan D. Wong, Heidi Gransar, Jagat Narula, Leslee Shaw, Johanna H. Moon, Romalisa Miranda-Peats, Alan Rozanski, Sean W. Hayes, Louise E.J. Thomson, John D. Friedman, Daniel S. Berman
Journal: JACC. Cardiovascular imaging (2009)
Disorders of Gastrointestinal Motility Associated with Diabetes Mellitus
Authors: MARK FELDMAN
Journal: Annals of Internal Medicine (1983)

Gastrointestinal symptoms such as vomiting, constipation, diarrhea, and fecal incontinence occur frequently in patients with diabetes mellitus. In a survey of 136 diabetic outpatients, 76% had one or more gastrointestinal symptoms, the commonest symptom being constipation (found in 60%). In many cases these symptoms are thought to be due to abnormal gastrointestinal motility that, in turn, may be a manifestation of diabetic autonomic neuropathy involving the gastrointestinal tract. The pathophysiology of these gastrointestinal symptoms, clarified in recent studies, and the clinical features and treatment of these problems in diabetic patients are reviewed.
129 MORTALITY IN PATIENTS WITH CHRONIC VERSUS CLEARED HCV INFECTION – A NATIONWIDE, POPULATION-BASED COHORT STUDY
Authors: L.H. Omland, H. Krarup, P. Jepsen, J. Georgsen, L.H. Harritshøj, K. Riisom, S.E.H. Jacobsen, P. Schouenborg, P.B. Christensen, H.T. Sørensen, N. Obel
Journal: Journal of Hepatology (2009)
Outcomes in liver transplantation: Does sex matter?
Authors: Monika Sarkar, Kymberly D. Watt, Norah Terrault, Marina Berenguer
Journal: Journal of Hepatology (2014)

A growing literature has highlighted important differences in transplant-related outcomes between men and women. In the United States there are fewer women than men on the liver transplant waitlist and women are two times less likely to receive a deceased or living-related liver transplant. Sex-based differences exist not only in waitlist but also in post-transplant outcomes, particularly in some specific liver diseases, such as hepatitis C. In the era of individualized medicine, recognition of these differences in the approach to pre and post-liver transplant care may impact short and long-term outcomes.
Abstract 5314: Calcium mediated growth control in normal and transformed colon cells: A possible role of the calcium sensing receptor.
Authors: Abhishek Aggarwal, Julia Höbaus, Irfete Sh. Fetahu, Ildikó Mesteri, Enikö Kállay
Journal: Cancer Research (2013)

Abstract Introduction: Calcium (Ca2+) plays an important role in regulating proliferation of colonic epithelium. Epidemiological studies suggest an inverse correlation between dietary Ca2+ intake and colorectal cancer (CRC) risk. However in CRC, transformed cells lose their sensitivity to the tumour inhibiting effects of Ca2+. We have shown that the extracellular calcium-sensing receptor (CaSR) expression is lost in CRC and therefore hypothesized that the CaSR mediates the effect of Ca2+ in regulating proliferation. Methods: We investigated the expression of the CaSR and of a cluster of genes responsible for ‘triggering off’ proliferation (CDT1, CDC6, CDC45, MCM2-7, Geminin, known as replication licensing genes) at mRNA level by qRT-PCR in CRC samples and in their respective ‘normal’ adjacent mucosa (n=57). To study the effect of Ca2+ in normal colon physiology, we fed male and female C57BL/6 mice with a diet containing high (0.9%) or low (0.1%) levels of Ca2+ and assessed the influence of dietary Ca2+ on proliferation (immunohistochemistry staining and mRNA expression) and CaSR mRNA expression. Results and Discussion: In tumours we found the expression of CaSR significantly downregulated when compared with respective adjacent mucosa (p&amp;lt;0.001). All genes involved in replication licensing are significantly higher expressed (p&amp;lt;0.001) in these samples. Our data suggest that the loss of CaSR gives the tumour cells growth advantage. In the tumour samples we found negative correlation between CaSR and licensing factors (CDC45 (p&amp;lt;0.05, ρ=−0.265) and MCM6 (p&amp;lt;0.05, ρ=−0.262) reaching significance). Surprisingly, CaSR showed positive correlation with the licensing factors in the ‘normal’ mucosa (CDT1 (p&amp;lt;0.05, ρ=0.269), MCM2 (p&amp;lt;0.003, ρ=0.382) and MCM5 (p&amp;lt;0.001, ρ=0.490) reaching significance). These results are similar to our observation in the mouse study, where low dietary Ca2+ enlarged the proliferative zone of the crypts with no significant change in CaSR expression. Conclusion: We conclude that the CaSR might regulate the calcium-dependent inhibition of proliferation in normal colonocytes. Upregulation of CaSR is probably a defence mechanism of the normal colon to control epithelial growth and counteract hyper-proliferative signals. This control mechanism is lost in cancer where CaSR expression is downregulated. Citation Format: Abhishek Aggarwal, Julia Höbaus, Irfete Sh. Fetahu, Ildikó Mesteri, Enikö Kállay. Calcium mediated growth control in normal and transformed colon cells: A possible role of the calcium sensing receptor. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5314. doi:10.1158/1538-7445.AM2013-5314
Reply to Tommaso Cai, Carolina D’Elia, and Beatrice Detti's Letter to the Editor re: Mieke Van Hemelrijck, Hans Garmo, Lars Holmberg, et al. Multiple Events of Fractures and Cardiovascular and Thromboembolic Disease Following Prostate Cancer Diagnosis: Results From the Population-Based PCBaSe Sweden. Eur Urol 2012;61:690–700
Authors: Mieke Van Hemelrijck, Pär Stattin, Jan Adolfsson
Journal: European Urology (2011)