tbuckley/cabot-search huggingface dataset:
Latex agglutination test and H.A.A.
Authors: M al-Hujaj, H Schonthal
Journal: BMJ (1972)

<h3>Aims</h3> To report the 6-year incidence of optical coherence tomography (OCT)-derived age-related changes in drusen volume and related systemic and ocular associations. <h3>Methods</h3> Chinese adults aged 40 years and older were assessed at baseline and 6 years with colour fundus photography (CFP) and spectral domain (SD) OCT. CFPs were graded for age-related macular degeneration (AMD) features and drusen volume was generated using commercially available automated software. <h3>Results</h3> A total of 4172 eyes of 2580 participants (mean age 58.12±9.03 years; 51.12% women) had baseline and 6-year follow-up CFP for grading, of these, 2130 eyes of 1305 participants had gradable SD-OCT images, available for analysis. Based on CFP grading, 136 (3.39%) participants developed incident early AMD and 10 (0.25%) late AMD. Concurrently, retinal pigment epithelial-Bruch’s membrane (RPE-BrC) volumes decreased, remained stable and increased in 6.8%, 78.5% and 14.7%, respectively, over 6 years. In eyes where RPE-BrC volumes were &gt;0 mm<sup>3</sup> at baseline, this was associated with two-fold higher prevalence rate of any AMD at baseline (p&lt;0.001). Multivariable analysis showed that when compared with eyes where RPE-BrC volume was unchanged, volume decrease was significantly associated with older age (OR=1.30; p&lt;0.001), smoking (OR=2.21; p=0.001) and chronic kidney disease (OR=3.4, p=0.008), while increase was associated with older age (OR=1.36; p&lt;0.001) and hypertension (OR=1.43; p=0.016). <h3>Conclusion</h3> AMD incidence detected at 6 years on CFP and correlated OCT-derived drusen volume measurement change is low. Older age and some systemic risk factors are associated with drusen volume change, and our data provide new insights into relationship between systemic risk factors and outer retinal morphology in Asian eyes.
Epitopes on H-2Dd somatic cell mutants recognized by cytotoxic T cells.
Authors: T A Potter, M A Palladino, D B Wilson, T V Rajan
Journal: The Journal of Experimental Medicine (1983)

We have generated several cell lines that express an altered H-2Dd molecule. These cell lines, which were selected for by the failure to express the serological specificity reacting with the monoclonal antibody 34-2-12, have also undergone alterations in epitopes recognized by CTL. One of the mutants, 2.12(-4) was not killed by an allogeneic anti-Dd CTL line, CTLL-A2, even though this line was cytotoxic for the parental cell line and two other 34-2-12- mutant lines. Two of the 34-2-12- mutant lines had an identical serological profile using other monoclonal Dd antibodies, however these two mutants differed markedly in their susceptibility to cytotoxicity by CTLL-A2. In addition to the determinants recognized by allogeneic CTL we also examined the effect of the mutation on the determinants involved in restricting the anti-FITC modified-self-cytotoxic response. An anti-FITC-Dd CTL line did not react with two of the mutants and reacted only weakly with the other mutant, demonstrating not only that the Dd epitopes recognized by this cell line and the allogeneic CTL were different, but also that it is possible for a H-2 class I molecule to express epitopes recognized by allogeneic CTL but not epitopes that function as restricting elements to certain antigens. The observation that both T cell- and B cell-defined determinants were altered in these mutant cell lines is in contrast to the findings, with the mutant mouse strains which were selected for by changes in T cell-defined determinants, which show few, if any, alterations to serological specificities. Characterization of T cell-recognized epitopes expressed on serologically selected somatic cell variants may therefore prove to be most useful for the study of structure-function relationships of H-2 class I molecules.
Clinical Experience with a New Convertible Panview Fiberscope
Authors: K. Yamada, T. Takemoto
Journal: Endoscopy (1974)

The experience with a multipurpose fiberscope is discussed. It is a new pan-endoscope with convertible antero-oblique, lateral viewing lenses designed for examining the upper gastrointestinal tract from the esophagus to the duodenal bulb. This ability can overcome the difficulty of endoscopic observation within the stomach and the duodenal bulb and offers ideal conditions for the observation of each part in the upper gastrointestinal tract, for example to detect the source of bleeding in urgent endoscopy, or in cases of stringent difficulties of insertion such as kyphosis, and so on.
Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b
Authors: Salil Garg, Mahak Sharma, Cindy Ung, Amit Tuli, Duarte C. Barral, David L. Hava, Natacha Veerapen, Gurdyal S. Besra, Nir Hacohen, Michael B. Brenner
Journal: Immunity (2011)

Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we identified the Arf-like GTPase Arl8b as a critical regulator of cargo delivery to lysosomes. Homotypic fusion and vacuole protein sorting (HOPS) complex members were identified as effectors of Arl8b and were dependent on Arl8b for recruitment to lysosomes, suggesting that Arl8b-HOPS plays a general role in directing traffic to lysosomes. Moreover, the formation of CD1 antigen-presenting complexes in lysosomes, their delivery to the plasma membrane, and phagosome-lysosome fusion were all markedly impaired in Arl8b silenced cells resulting in corresponding defects in T cell activation and microbial killing. Together, these results define Arl8b as a key regulator of lysosomal cellular and immunological functions.
Khin Khin San
Authors: N Chalabi
Journal: BMJ (2003)

Former general practitioner east London (b Burma 1951; q Rangoon 1976), d 27 June 2003.

Dr San came to the United Kingdom in 1979, where she trained as a general practitioner and worked in community paediatrics until 1997. She then went on to work as a partner in general practice at St Johns Road Medical Centre, East Ham.
Mental Stress Provokes Ischemia in Coronary Artery Disease Subjects Without Exercise- or Adenosine-Induced Ischemia
Authors: Srikanth Ramachandruni, Roger B. Fillingim, Susan P. McGorray, Carsten M. Schmalfuss, Gary R. Cooper, Richard S. Schofield, David S. Sheps
Journal: Journal of the American College of Cardiology (2006)
Evaluation of Endoscopic Retrograde Cholangiopancreatography Under Conscious Sedation and General Anesthesia
Authors: K. Raymondos, B. Panning, I. Bachem, M. P. Manns, S. Piepenbrock, P. N. Meier
Journal: Endoscopy (2002)

Background and Study Aims: In adults, general anesthesia is usually only provided during endoscopic retrograde cholangiopancreatography (ERCP) when prior attempts using conscious sedation have failed. It was hypothesized that in our hospital, other factors might be associated with general anesthesia for ERCP. The aim of this study was therefore to assess the indications for ERCP under general anesthesia, and to evaluate the underlying diseases, type, and efficacy of ERCP under general anesthesia in comparison with conscious sedation. Patients and Methods: We retrospectively analyzed 1056 ERCPs that had been carried out with the patients under general anesthesia or conscious sedation. The indications for general anesthesia were recorded, and the underlying diseases, the type and success of the interventions, and the causes of premature ERCP termination in both groups were assessed. Results: Eighteen percent of the ERCPs were performed under general anesthesia and 82 % under conscious sedation. The indications for general anesthesia were related to the type of procedure planned (46 %), premature termination of ERCP under conscious sedation (28 %), and other reasons. Patients with primary sclerosing cholangitis and liver transplant recipients received general anesthesia more frequently (general anesthesia vs. conscious sedation, 36 % vs. 16 %, P < 0.0001 and 22 % vs. 13 %, P = 0.003). Conscious sedation was provided more frequently in patients with neoplasms and cholelithiasis (21 % vs. 12 %, P = 0.004 and 13 % vs. 3 %, P < 0.001). Painful dilations were performed more frequently with the patients under general anesthesia (60 % vs. 19 %, P < 0.001), whereas major papillotomies were preferably performed with conscious sedation (34 % vs. 21 %, P = 0.006). More interventions per ERCP were performed with the patient under general anesthesia compared to conscious sedation (P < 0.001), during the same time (51 ± 28 min vs. 52 ± 26 min, P = 0.39). With conscious sedation, the ERCP failure rate was double that with general anesthesia (7 % vs. 14 %, P = 0.012), mainly due to inadequate conscious sedation (61 %). Conclusions: The frequent use of general anesthesia for ERCP at our institution is related to the underlying diseases, which are frequently treated with complex and painful ERCP procedures. The efficacy of ERCP with general anesthesia supports a continued preference for general anesthesia rather than conscious sedation when complex and painful interventional ERCP procedures are planned.
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Authors: Patricia A Darrah, Dipti T Patel, Paula M De Luca, Ross W B Lindsay, Dylan F Davey, Barbara J Flynn, Søren T Hoff, Peter Andersen, Steven G Reed, Sheldon L Morris, Mario Roederer, Robert A Seder
Journal: Nature Medicine (2007)
Injuries to the lateral ligament of the ankle: assessment and treatment.
Authors: M. A. Hutson, J. P. Jackson
Journal: British Journal of Sports Medicine (1982)

Initial assessment of severity of injury to the lateral ligament of the ankle is by clinical examination. If it is thought that there is a possibility of either lateral or anterior instability, patients are investigated radiologically by anterior and inversion stress films. If instability is demonstrated a peroneal tenogram is carried out to exclude damage to the calcaneo-fibular ligament. Treatment is by means of a cast brace if instability is present. The advantages of this are preservation of calf power and improved joint function. The early results are reported in relation to the improvement in stability and early return to sporting activity.
Routine Chest X-ray Films in a Veterans Hospital
Authors: Daniel J. Fink
Journal: JAMA (1981)

The routine chest x-ray films of 113 patients admitted to two general medicine wards at a Veterans Administration hospital were analyzed to determine the value of this examination in screening for new chest abnormalities. The admission chest x-ray films of 52 patients (46%) revealed abnormal findings. The prevalence of abnormality was much greater than in other recently reported series. This study suggests that obtaining routine admission chest x-ray films continues to be necessary for hospitals with a high prevalence of intrathoracic disease, such as those hospitals serving veterans.
Symbols in numbers: From numerals to magnitude information
Authors: Oliver Lindemann, Shirley-Ann Rueschemeyer, Harold Bekkering
Journal: Behavioral and Brain Sciences (2009)

Abstract A dual-code model of number processing needs to take into account the difference between a number symbol and its meaning. The transition of automatic non-abstract number representations into intentional abstract representations could be conceptualized as a translation of perceptual asemantic representations of numerals into semantic representations of the associated magnitude information. The controversy about the nature of number representations should be thus related to theories on embodied grounding of symbols.
STUDIES OF CRIMINALS. DEGENERACY OF CRANIAL AND MAXILLARY DEVELOPMENT IN THE CRIMINAL CLASS, WITH A SERIES OF ILLUSTRATIONS OF CRIMINAL SKULLS, AND HISTORIES TYPICAL OF THE PHYSICAL DEGENERACY OF THE CRIMINAL.Read in ihe Section of Medical Jurisprudence and Neurology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: G. FRANK LYDSTON
Journal: JAMA (1891)

The mutuality of interest involved in their studies of the degenerate classes, has led the authors of this paper to combine their observations in a joint paper. This paper, however, is too lengthy for presentation to this Section. We have, therefore, abridged the subject-matter as far as possible, with the view of presenting only the most important features of the essay, reserving its complete publication until some future time. The present paper comprises a portion of an address upon "The Skulls of Criminals," with cuts of the more important specimens, delivered by Dr. Lydston, at the meeting of the Mississippi Valley Medical Association, September 11, 1890, together with some of Dr. Talbot's studies of the jaws of the degenerate classes, and deductions drawn from an extensive series of cooperative studies of criminals. No attempt has been made to formulate an arbitrary theory regarding the crime class. Indeed, it is the
Diuretics stimulate H+ secretion in turtle urinary bladder.
Authors: P D Lief, B F Mutz, N Bank
Journal: Journal of Clinical Investigation (1980)

The effect of various diuretics on H+ secretion was studied in the isolated short-circuited urinary bladder of the turtle. Mucosal (urinary) chlorothiazide stimulated H+ secretion promptly, from 1.33 +/- 0.24 to 3.03 +/- 0.25 mueq/h (P less than 0.001). The effect was rapidly reversible upon washout of the drug, H+ returning to control levels, 1.37 +/- 0.26 mueq/h (P less than 0.001). Similar effects were observed with mucosal hydrochlorothiazide and mucosal ethacrynic acid/cysteine. Stimulation of H+ secretion occurred in the presence or the absence of exogenous CO2, in the presence or absence of mucosal Na+ and during inhibition of Na+ transport by ouabain. There was no stimulation of H+ secretion by uncomplexed ethacrynic acid or by mucosal furosemide. The nondiuretic sulfonamide, sulfasoxizole, and the nonsulfonamide buffer, borate, had no effect on H+ SECRETION. These observations indicate that the stimulatory effect of diuretics on H+ secretion is not related to active sodium transport, transepithelial electrical potential, or the buffering capacity of the drugs. Since the transepithelial pH gradient at which active H+ secretion was abolished was identical for chlorothiazide-treated tissues (2.68 pH U) as for control tissues (2.65 pH U, NS), the data suggest that the protonmotive force of the H+ pump was unaffected by the diuretic. This observation, plus the rapid onset and reversibility of the drugs, is consistent with an effect on the mucosal membrane to increase H+ conductance (K). The findings raise the possibility that direct enhancement of renal H+ secretion may play a role in the metabolic alkalosis induced by some diuretics.
Meeting Meaningful Use Criteria and Managing Patient Populations
Authors: Richard Schreiber
Journal: Annals of Internal Medicine (2013)

Letters19 November 2013Meeting Meaningful Use Criteria and Managing Patient PopulationsRichard Schreiber, MDRichard Schreiber, MDFrom Holy Spirit Hospital, Camp Hill, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-10-201311190-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITORDesRoches and colleagues’ survey (1) shows that human behavior resists even beneficial change. I have 2 main disagreements with their conclusions. First, that “[f]ew physicians could meet meaningful use criteria in early 2012” at the beginning of adoption of these criteria is predictable and not due to physician influence alone. Second, that “perceived ease of use of systems that can help to manage patient populations should be of concern to policymakers” may be true, but the survey questions do not allow this conclusion.Gross (2) and Ryan and Gross (3) described and Rogers (4) popularized the idea ...References1. DesRoches CM, Audet AM, Painter M, Donelan K. Meeting meaningful use criteria and managing patient populations: a national survey of practicing physicians. Ann Intern Med. 2013;158:791-9. [PMID: 23732712] LinkGoogle Scholar2. Gross NC. The Diffusion of a Culture Trait in Two Iowa Townships [master's thesis]. Ames, Iowa: Iowa State Coll; 1942. Google Scholar3. Ryan B, Gross NC. The diffusion of hybrid seed corn in two Iowa communities. Rural Sociol. 1943;8:15-24. Google Scholar4. Rogers EM. Diffusion of Innovations. Glencoe, Illinois: Free Pr; 1962. Google Scholar5. Ford EW, Menachemi N, Peterson LT, Huerta TR. Resistance is futile: but it is slowing the pace of EHR adoption nonetheless. J Am Med Inform Assoc. 2009;16:274-81. [PMID: 19261931] CrossrefMedlineGoogle Scholar6. U.S. Department of Health and Human Services. Doctors and hospitals' use of health IT more than doubles since 2012 [press release]. Washington, DC: U.S. Department of Health and Human Services; 22 May 2013. Accessed at www.hhs.gov/news/press/2013pres/05/20130522a.html on 7 June 2013. Google Scholar Author, Article, and Disclosure InformationAuthors: Richard Schreiber, MDAffiliations: From Holy Spirit Hospital, Camp Hill, Pennsylvania.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeeting Meaningful Use Criteria and Managing Patient Populations Catherine M. DesRoches , Anne-Marie Audet , Michael Painter , and Karen Donelan Meeting Meaningful Use Criteria and Managing Patient Populations Philip A. Verhoef Metrics 19 November 2013Volume 159, Issue 10Page: 717KeywordsBehaviorConflicts of interestElectronic medical recordsHealth care sectorHospitalistsMedicarePerceptionPopulation statistics ePublished: 19 November 2013 Issue Published: 19 November 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Limited Joint Mobility in Childhood Diabetes Mellitus Indicates Increased Risk for Microvascular Disease
Authors: Arlan L. Rosenbloom, Janet H. Silverstein, Dennis C. Lezotte, Kathryn Richardson, Martha McCallum
Journal: New England Journal of Medicine (1981)

We detected limited mobility of small and large joints in 92 (30 per cent) of 309 patients with diabetes who were one to 28 years old. Among patients who had had diabetes for more than 4.5 years (the shortest duration at which microvascular complications were noted), 82 of 169 had joint limitation. Forty-one of these 82 also had microvascular complications, but only 10 of the 87 patients without joint limitation had complications. Life-table analysis indicated an 83 per cent risk for microvascular complications after 16 years of diabetes if joint limitation was present, but only a 25 per cent risk if joint limitation was absent. Consequently, limited joint mobility identifies a population exceptionally at risk for the early development of microvascular complications, and intervention to forestall or prevent these complications can now be focused.
Long-Term and Significant Correction of Brain Lesions in Adult Mucopolysaccharidosis Type VII Mice Using Recombinant AAV Vectors
Authors: Assumpció Bosch, Emmanuelle Perret, Nathalie Desmaris, Jean Michel Heard
Journal: Molecular Therapy (2000)

Most lysosomal storage diseases, including mucopolysaccharidosis, affect the central nervous system (CNS). They often induce severe and progressive mental retardation. Replacement therapy by purified enzyme infusions is a promising approach for the treatment of peripheral organs but without effect on CNS pathology because the enzyme cannot cross the blood–brain barrier. Intracranial injection of recombinant adeno-associated virus (AAV) vectors offers an alternative for sustained local enzyme delivery from genetically engineered cells. We stereotactically injected an AAV vector containing the human β-glucuronidase cDNA into the striatum of adult mice severely affected by mucopolysaccharidosis type VII at the time of treatment. Six weeks later, β-glucuronidase activity in the injected hemisphere was comparable to that of heterozygous mice, which have a normal phenotype. Areas staining positive for enzyme activity enlarged with time, representing more than 10% of the hemisphere volume by 16 weeks. A complete reversion of lysosomal storage lesions was evident in these areas, as well as in most neurons located in surrounding negative areas and in the noninjected hemisphere. Thus, a single intracerebral injection of AAV vectors could achieve a broad and sustained lysosomal enzyme delivery, allowing for stable reversion of storage lesions in a significant fraction of the adult brain.
Olopatadine HCl nasal spray is effective and safe for the treatment of seasonal (Mountain Cedar) allergic rhinitis*1
Authors: P.H. Ratner, F.C. Hampel, N.J. Amar, J.H. van Bavel, D. Mohar, G.M. Wall, M. Brubaker, M. Drake, S. Potts
Journal: Journal of Allergy and Clinical Immunology (2004)
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.
Authors: H G Welgus, E J Campbell, J D Cury, A Z Eisen, R M Senior, S M Wilhelm, G I Goldberg
Journal: Journal of Clinical Investigation (1990)

Mononuclear phagocytes are developmentally and functionally complex cells that play critical roles in extracellular matrix remodeling. We hypothesized that differentiated mononuclear phagocytes, typified by alveolar macrophages, use a spectrum of metalloproteinases to degrade various matrix macromolecules. To test this hypothesis, we have evaluated synthesis and secretion of four metalloproteinases (interstitial collagenase, stromelysin, 72-kD type IV collagenase, and 92-kD type IV collagenase) by human mononuclear phagocytes with regard to (a) the effect of cellular differentiation, (b) regulation of secretion, and (c) comparisons/contrasts with a prototype metalloproteinase-secretory cell, the human fibroblast. We found that regulated secretion of greater quantities and a wider spectrum of metalloenzymes correlated with a more differentiated cellular phenotype. As extreme examples, the 92-kD type IV collagenase was released by peripheral blood monocytes and uninduced U937 monocyte-like cells, whereas stromelysin was secreted only by lipopolysaccharide-stimulated alveolar macrophages. Macrophage production of interstitial collagenase, stromelysin, and 72-kD type IV collagenase was approximately 20%, 10%, and 1-2%, respectively, of that from equal numbers of fibroblasts; secretion of the 92-kD type IV collagenase was not shared by fibroblasts. This work confirms the potential of macrophages to directly degrade extracellular matrix via secreted metalloproteinases in a manner that differs both qualitatively and quantitatively from that of fibroblasts. Moreover, varying regulation of metalloenzyme synthesis, evidenced by distinct patterns of basal and stimulated secretion during differentiation, can be studied at a molecular level in this model system.
The Effect of Midazolam on Motility of the Sphincter of Oddi in Human Subjects
Authors: J. C. Cuer, M. Dapoigny, G. Bommelaer
Journal: Endoscopy (1993)

Midazolam, a water-soluble benzodiazepine, has recently been introduced and found to be beneficial for sedation in upper GI endoscopy. Whereas it has been proven that diazepam does not have any effect on sphincter of Oddi (SO) motility in humans, no respective data exist on midazolam. On evaluation of the possible effects of midazolam on SO motility recording by means of endoscopic manometry, we found that midazolam had no effect on basal pressure (24.2 +/- 12.59 mm Hg before and 23.85 +/- 12.63 mm Hg after midazolam, p = 0.55), amplitude (39.75 +/- 22.62 versus 44.55 +/- 27.15, p = 0.097), duration (4.9 +/- 1.8 sec versus 5.05 +/- 1.7 sec, p = 0.614), and frequency of SO contractions (7.75 +/- 1.68 waves/min versus 7.15 +/- 1.92 waves/min, p = 0.083). These results suggest that in patients with normal manometric findings midazolam does not interfere with SO recording.