tbuckley/cabot-search huggingface dataset:
Increased Cardiomyocyte Apoptosis and Changes in Proapoptotic and Antiapoptotic Genes <i>bax</i> and <i>bcl</i> -2 During Left Ventricular Adaptations to Chronic Pressure Overload in the Rat
Authors: Gianluigi Condorelli, Carmine Morisco, Giorgio Stassi, Antonella Notte, Felicia Farina, Giuseppe Sgaramella, Assunta de Rienzo, Roberta Roncarati, Bruno Trimarco, Giuseppe Lembo
Journal: Circulation (1999)

Background —Left ventricular hypertrophy (LVH) represents both an adaptive response to increased cardiac work load and a precursor state of heart failure. Recent evidence linked cardiac myocyte death by apoptosis with LVH and heart failure. It remained unclear, however, whether apoptosis participated in the transition from LVH to left ventricular dysfunction (LVD). Methods and Results —Cardiac myocyte apoptotic events and changes in apoptosis-specific genes were studied in a rat model of chronic pressure overload induced by transverse aortic constriction. The changes in left ventricular geometry and function were assessed by echocardiography. Transverse aortic constriction rats progressively developed “concentric” LVH and subsequently, LVD. A similar distribution of LVH and LVD was found 18 weeks after surgery. At this time point, we determined the occurrence of myocyte apoptosis by DNA laddering, in situ DNA TUNEL labeling, and light and electron microscopy. The monitoring of proapoptotic and antiapoptotic genes was determined by Western blot and immunohistochemistry. Our data demonstrated that cardiomyocyte apoptotic events increased from virtually undetectable (in sham-operated controls, SH) to 0.8/10 3 and 1.5/10 3 positive nuclei in LVH and LVD, respectively. Fibrosis also increased in the subendocardial and midwall regions of LVH and LVD rats compared with SH. Expression of the proapoptotic gene bax increased, whereas that of antiapoptotic gene bcl -2 decreased in LVH and LVD compared with SH. Conclusions —These data suggest that in response to chronic pressure overload, cardiomyocyte-specific apoptosis contributed to the transition from LVH to LVD. LVH and LVD were accompanied by a dramatic cardiomyocyte upregulation of the proapoptotic gene bax and reduced bcl -2/ bax ratio, predisposing cardiomyocytes to apoptosis.
Aminophylline and Cardiac Arrest
Authors: Joseph Varon
Journal: Annals of Internal Medicine (1993)

Letters15 September 1993Aminophylline and Cardiac ArrestJoseph Varon, MD and Robert E. Fromm Jr., MDJoseph Varon, MDSearch for more papers by this author and Robert E. Fromm Jr., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We agree with Viskin and coworkers [1] that aminophylline may have a role in the management of bradyasystolic cardiac arrest [2-4]. However, optimism should be tempered by our lack of experience and the uncontrolled nature of Viskin and colleagues' experiment. It is surprising that the authors observed a response to aminophylline therapy within 30 seconds of administration, given the relatively prolonged circulation time previously documented for patients in cardiac arrest [5]. Was a central venous catheter used for administration? The absence of a control group makes it impossible to conclude with certainty that the return of spontaneous ...References1. Viskin S, Belhassen B, Roth A, Reicher M, Averbuch M, Sheps D, et al. Aminophylline for bradyasystolic cardiac arrest refractory to atropine and epinephrine. Ann Intern Med. 1993; 118:279-81. Google Scholar2. Orlowski JP. Pediatric cardiopulmonary resuscitation. Emerg Med Clin North Am. 1983; 1:3-25. Google Scholar3. Muthu P, Krishnamoorthy MS, Kumaravel TS. Effect of aminophylline preperfusion on digoxin-induced cardiac arrest in isolated frog heart. Indian J Exp Biol. 1991; 29:870-1. Google Scholar4. Tomcsanyi J, Grosz A, Karlocai K. Abolishing a sinus arrest resistant to atropine by aminophylline. Int J Cardiol. 1990; 29:96-8. Google Scholar5. Hedges JR, Barsan WB, Doan LA, et al. Central versus peripheral intravenous routes in cardiopulmonary resuscitation. Am J Emerg Med. 1984; 2:385-90. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1993Volume 119, Issue 6Page: 536KeywordsAtropineCardiac arrestCathetersEpinephrineHeartResuscitation Issue Published: 15 September 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
William Porteous Small
Authors: Martin Eastwood
Journal: BMJ (2004)

Former general and gastrointestinal surgeon Western General Hospital, Edinburgh (b Edinburgh 1920; q Edinburgh 1942; FRCS Ed, FRCP Ed, ChM, VRD), died from prostate cancer on 25 March 2004.​2004.




Figure 1




After graduation Bill served in the Royal Naval Volunteer Reserve, retiring as surgeon commander. Following training in Edinburgh he was appointed consultant surgeon in 1955. He pioneered surgical audit with a gastric follow up clinic for patients who had undergone surgery for duodenal ulcer. His paper in the New England Journal of Medicine (NEJM 1982;307: 519-22 [PubMed]) on late mortality after surgery for peptic ulceration showed that smoking significantly increased patients' chances of requiring surgery and significantly shortened life expectancy. Bill enjoyed cycling, woodwork, gardening, tuneless whistling, the Friends of the Hospital, and the kirk. He leaves a wife, Tordis; three sons and two adopted daughters; and seven grandchildren.
Fags and feminism
Authors: J. O. Drife
Journal: BMJ (1995)

Good weather brings the patients to the front door. After the ward round their pains abate and they wheel their drip stands into the lift. On armchairs dragged from the foyer they sit, in dressing gowns and antiembolism stockings, enjoying their first cigarette of the day.

The sight does not inspire their carers. We like to believe in the myth of the deserving patient who needs our protection. Instead we see self confident women with rhonchi, forsaking their £700-a-day beds for a drag and a gossip about the perceived inadequacies of the NHS.

If I'm having a bad day …
The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs
Authors: Frank G. Lyons, Amir A. Al-Munajjed, Stephen M. Kieran, Mary E. Toner, Ciara M. Murphy, Garry P. Duffy, Fergal J. O’Brien
Journal: Biomaterials (2010)
Response to Letter Regarding Article, “Dosing of Clopidogrel for Platelet Inhibition in Infants and Young Children: Primary Results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) Trial”
Authors: Jennifer S. Li, Eric Yow, Katherine Y. Berezny, Paula M. Bokesch, Matsato Takahashi, Thomas P. Graham, Stephen P. Sanders, Daniel Sidi, Damien Bonnet, Peter Ewert, Lisa K. Jennings, Alan D. Michelson
Journal: Circulation (2008)
Microalbuminuria, High Blood Pressure Burden, and Nondipper Phenomenon
Authors: Cesar N. Cohen, Francisco M. Albanesi, Maria F. Gonçalves, Marília B. Gomes
Journal: Diabetes Care (2001)

Type 1 diabetes is associated with hypertension and increased risk of morbidity and mortality attributable to cardiovascular disease and renal failure. Almost 40% of patients with type 1 diabetes will develop clinical diabetic nephropathy, defined as urinary albumin excretion rate (AER) >300 mg/24 h (1). We studied 37 normotensive type 1 diabetic patients without macroalbuminuria, aged 26.5 ± 6.75 years and with 9.4 years (range 1–34) of disease, and 28 normotensive nondiabetic subjects with fasting glucose blood levels ≤100 mg/dl, aged 24.9 ± 6.81 years, who were matched to the diabetic group for age, sex, skin color, weight, height, and BMI. Albumin concentration was measured by double-antibody radioimmunoassay (DPC, Los Angeles, CA). Ambulatory blood pressure monitoring (ABPM) was performed during a working day using a portable automatic oscillometric recorder …
Living Near Variety Children's Hospital
Authors: Michelle Perez
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multifunctional mesenchymal cells resembling smooth muscle cells in ganglia of the wrist.
Authors: F N Ghadially, P N Mehta
Journal: Annals of the Rheumatic Diseases (1971)

<h3>Abstract</h3> Multisystem Inflammatory Syndrome in Children (MIS-C) is a delayed-onset, COVID-19-related hyperinflammatory systemic illness characterized by SARS-CoV-2 antigenemia, cytokine storm and immune dysregulation; however, the role of the neutrophil has yet to be defined. In adults with severe COVID-19, neutrophil activation has been shown to be central to overactive inflammatory responses and complications. Thus, we sought to define neutrophil activation in children with MIS-C and acute COVID-19. We collected samples from 141 children: 31 cases of MIS-C, 43 cases of acute pediatric COVID-19, and 67 pediatric controls. We found that MIS-C neutrophils display a granulocytic myeloid-derived suppressor cell (G-MDSC) signature with highly altered metabolism, which is markedly different than the neutrophil interferon-stimulated gene (ISG) response observed in pediatric patients during acute SARS-CoV-2 infection. Moreover, we identified signatures of neutrophil activation and degranulation with high levels of spontaneous neutrophil extracellular trap (NET) formation in neutrophils isolated from fresh whole blood of MIS-C patients. Mechanistically, we determined that SARS-CoV-2 immune complexes are sufficient to trigger NETosis. Overall, our findings suggest that the hyperinflammatory presentation of MIS-C could be mechanistically linked to persistent SARS-CoV-2 antigenemia through uncontrolled neutrophil activation and NET release in the vasculature. <h3>One Sentence Summary</h3> Circulating SARS-CoV-2 antigen:antibody immune complexes in Multisystem Inflammatory Syndrome in Children (MIS-C) drive hyperinflammatory and coagulopathic neutrophil extracellular trap (NET) formation and neutrophil activation pathways, providing insight into disease pathology and establishing a divergence from neutrophil signaling seen in acute pediatric COVID-19.
Gap junction alterations in human cardiac disease
Authors: N Severs
Journal: Cardiovascular Research (2004)

Journal Article Gap junction alterations in human cardiac disease Get access Nicholas J. Severs, Nicholas J. Severs * aCardiac Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK *Corresponding author. Tel.: +44-20-7351-8140; fax: +44-20-7351-8476. Email address: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Steven R. Coppen, Steven R. Coppen aCardiac Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Emmanuel Dupont, Emmanuel Dupont aCardiac Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Hung-I Yeh, Hung-I Yeh bCardiac Medicine, Mackay Memorial Hospital, Taipei, Taiwan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yu-Shien Ko, Yu-Shien Ko cFirst Cardiovascular Division, Chang Gung Memorial Hospital, Taipei, Taiwan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tsutomu Matsushita Tsutomu Matsushita dDepartment of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 62, Issue 2, May 2004, Pages 368–377, https://doi.org/10.1016/j.cardiores.2003.12.007 Published: 01 May 2004 Article history Received: 15 October 2003 Revision received: 03 December 2003 Accepted: 05 December 2003 Published: 01 May 2004
Comparison of Subjective Estimates by Surgeons and Anaesthetists of Operative Blood Loss
Authors: A. E. Delilkan
Journal: BMJ (1972)

Altogether 100 cases were studied to compare the subjective estimates of operative blood loss by anaesthetists (six in number) and by surgeons (22 in number). Their estimates were compared with the blood loss measured by a colorimetric method, which was assumed to be the operative blood loss. The results showed that surgeons are less reliable judges of operative blood loss then anaesthetists. When objective measurement of operative blood loss is impracticable the anaesthetist and the surgeon should jointly make a subjective estimation.
Abstract 2382: IGFBP-3 regulates angiogenesis through upregulation of TSP-1
Authors: Pao-Ling Torng, Ho-Jun Shih, Su-Cheng Huang, Chin-Tarng Lin
Journal: Cancer Research (2010)

Abstract Insulin growth factor binding protein-3 (IGFBP-3) has been postulated to be a mediator of growth suppression signal. In our previous study, IGFBP-3 was found as an invasion suppressor gene in ovarian endometrioid carcinoma (OEC) (Oncogene 2008;27:2137-47). It was silenced through IGFBP-3 promoter methylation, which was associated with cancer progression (Mol Cancer, in press). Through microarray analysis, we further identified that IGFBP-3 expression was associated with an elevation of thrombospondin-1 (TSP-1), which is an endogenous inhibitor of angiogenesis. We established a tetracyclin-inducible IGFBP-3 expressing OEC cell line using pBIG2i plasmid (OVTW59 P4-D-I: pBIG2i-hIGFBP3). This cell line showed 4-fold increase in IGFBP-3 expression 2 hours after tetracyclin treatment, associated with an paraellel increase in TSP-1. Expression of IGFBP-3 decreases cell migration and capillary tube formation, which was reversed after anti-TSP-1 treatment. By chick embryo chorioallantoic membrane (CAM) assay, IGFBP-3 expression showed a significant decrease in capillary formation. Heterotransplantation of IGFBP-3-transfectants significantly decrease in tumor growth 5 days after IGFBP-3 induction. Such dormancy state of tumor growth persisted for about 10 days. Xenograft tumors during this period showed a decrease in microvessel density and an increase in tumor apoptosis. In conclusion, we have identified a novel association between IGFBP-3 expression and TSP-1 elevation that consequently results in a decrease in angiogenesis. Such impairment in angiogensis could be associated with the dormancy state of cancer growth and may represent a major function of the oncosupressor IGFBP-3 in ovarian cancer pathogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2382.
The cyclotron saga continues
Authors: W. E Powers, R. L Maughan
Journal: BMJ (1990)

SPEAR is out of place as Ledingham et al them- selves say in the same paper that the respective roles of cefotaxime and of intestinal decontamina- tion "have still to be determined.""My comment on the danger of the systemic component stems from the ability of third generation cephalosporins to stimulate ji lactamases in the bacterial genera that are not uncommon in intensive therapy units.Mv main contention is that further evidence is required of the need for the systemic component, in view of the lack of studies defining its effect, as well as of the respective roles of oropharyngeal and gastrointestinal decontamination and of gastric acidity.
Psychosis after Eye Surgery
Authors: Avery D. Weisman, Thomas P. Hackett
Journal: New England Journal of Medicine (1958)

FEW physicians would dispute the importance of the doctor–patient relation in facilitating recovery from an illness. Although the factors involved in this relation in psychiatry apply equally to patients with medical and surgical disorders, only rarely have internists or surgeons made conscious efforts to establish an appropriate therapeutic relation in advance. Instead, the absence of precise knowledge has led to vague recommendations for "good," "supporting" or "friendly" relations without specific instructions how this may be accomplished. Often, it is after the fact that the doctor decides that his relation has been appropriate and therapeutically advantageous.Certain eye patients who enter . . .
Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population
Authors: Qingyi Wei, Dianke Yu, Mingbo Liu, Mengyun Wang, Miaoqing Zhao, Ming Liu, Weihua Jia, Hongxia Ma, Jugao Fang, Wei Xu, Kexing Chen, Zhengang Xu, Jialing Wang, Linli Tian, Hua Yuan, Jiang Chang, Zhibin Hu, Lixun Wei, Ying Huang, Yaling Han, Jie Liu, Demin Han, Hongbing Shen, Shiming Yang, Hong Zheng, Qinghai Ji, Duanshu Li, Wen Tan, Chen Wu, Dongxin Lin
Journal: Nature Genetics (2014)
Diagnostic Accuracy of Salivary Scintigraphic Indices in Xerostomic Populations
Authors: GEORGE A. HERMANN, FREDERICK B. VIVINO, DARRYL SHNIER, ROBERT P. KRUMM, VALERY MAYRIN
Journal: Clinical Nuclear Medicine (1999)

Purpose: Three decades of work to enhance the diagnostic accuracy of salivary scintigraphy have generated various plausible decision criteria. This study evaluates four commonly cited numeric indices in studies of xerostomic populations and how accurately they identify Sjögren's syndrome, chronic sialadenitis, radiation sialadenitis, and drug effects and distinguish each from the other. Methods: Stimulated dynamic salivary scintigraphy was performed on 295 xerostomic patients and on 31 controls. The nonparametric area under the receiver operating characteristic curves expressed the diagnostic accuracy of the following scintigraphic indices: the parotid:submandibular ratio of unstimulated glandular activity, the peak:baseline uptake ratio, its time of occurrence, and the stimulated excretion fraction. Results: The stimulated excretion fraction distinguished Sjögren's syndrome and radiation sialadenitis from healthy states with respective accuracies of 0.78 and 0.90. The maximum diagnostic payoff in Sjögren's syndrome occurred at a cutoff of 73%, yielding a 73% rate of test sensitivity and a 73% rate of specificity. The other three indices were not useful. Even the stimulated excretion fraction performed indifferently or poorly in most other diagnostic tasks. Conclusions: In the scintigraphic examination of xerostomic and healthy populations, an acceptable diagnostic utility of the stimulated excretion fraction was evident only in Sjögren's syndrome and radiation sialadenitis. When presented with differential diagnostic alternatives not involving radiation sialadenitis, none of the four numeric indices performed acceptably.
Serum and faecal lysozyme in inflammatory bowel disease.
Authors: H J Klass, G Neale
Journal: Gut (1978)

Lysozyme (EC 3.2.1.17) concentrations were measured in the serum and stools of patients with inflammatory bowel disease and compared with the concentrations in similar material from normal controls, patints with non-inflammatory gastrointestinal disease, and patients without gastrointestinal disease. By the turbidometric method, values of lysozyme (microgram/ml +/- SD) are considerably greater in the serum of patients with active Crohn's disease (9.2 +/- 2.7) than in the serum of healthy controls (4.4 +/- 2.0). They do not, however, distinguish individual patients with Crohn's disease from those with ulcerative colitis nor from those with a variety of other gastrointestinal conditions. The lysoplate method gives much higher values for serum lysozyme than the turbidometric method but there is a considerable overlap between the results for patients with Crohn's disease (60.1 +/- 30.7) and normal controls (27.4 +/- 17.5). There is only a moderate correlation between the results given by the two methods (r = 0.56) and it is suggested that factors other than enzyme activity and methodological variation are responsible for the observed differences. This is supported by the finding that, with Crohn's disease in remission, serum lysozyme values (lysoplate) return to normal values but with the turbidometric method remain raised. Mean faecal lysozyme levels, expressed either as a concentration or as total daily excretion, in patients with inflammatory bowel disease are very significantly greater than values in healthy controls and in diseased subjects without diarrhoea but are not significantly different from those subjects with other causes of diarrhoea.