Diagnosing Primary HIV Infection
Authors: Eric S. Daar, Susan Little
Journal: Annals of Internal Medicine (2002)

Letters19 March 2002Diagnosing Primary HIV InfectionEric S. Daar, MD and Susan Little, MDEric S. Daar, MDHarbor-UCLA Medical CenterTorrance, CA 90502University of California, San DiegoSan Diego, CA 92103Search for more papers by this author and Susan Little, MDHarbor-UCLA Medical CenterTorrance, CA 90502University of California, San DiegoSan Diego, CA 92103Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-6-200203190-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Our study was designed to distinguish between symptomatic patients who had primary HIV infection and those who did not. Since primary HIV infection can present with a broad range of clinical manifestations (1), all referred patients, regardless of symptom complex, were screened. Thus, on the basis of our analysis, which is consistent with that of others (2), we stand by our conclusions that screening should not be limited to patients with select symptoms.We agree that our estimate of p24 antigen sensitivity could be misinterpreted. Nevertheless, our study demonstrates that this assay can be used to diagnose primary HIV infection ...References1. Vanhems P, Allard R, Cooper DA, Perrin L, Vizzard J, Hirschel B, et al . Acute human immunodeficiency virus type 1 disease as a mononucleosis-like illness: is the diagnosis too restrictive? Clin Infect Dis. 1997;24:965-70. [PMID: 9142802] CrossrefMedlineGoogle Scholar2. Bollinger RC, Brookmeyer RS, Mehendale SM, Paranjape RS, Shepherd ME, Gadkari DA, et al . Risk factors and clinical presentation of acute primary HIV infection in India. JAMA. 1997;278:2085-9. [PMID: 9403423] CrossrefMedlineGoogle Scholar3. Flanigan T, Tashima KT. Diagnosis of acute HIV infection: it's time to get moving! [Editorial]. Ann Intern Med. 2001;134:75-7. [PMID: 11187423] LinkGoogle Scholar4. Schacker T, Collier AC, Hughes J, Shea T, Corey L. Clinical and epidemiologic features of primary HIV infection. Ann Intern Med. 1996;125:257-64. [PMID: 8678387] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Eric S. Daar, MD; Susan Little, MDAffiliations: Harbor-UCLA Medical CenterTorrance, CA 90502University of California, San DiegoSan Diego, CA 92103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDiagnosis of Acute HIV Infection: It's Time To Get Moving! Timothy Flanigan and Karen T. Tashima Diagnosis of Primary HIV-1 Infection Eric S. Daar , Susan Little , Jacqui Pitt , Joanne Santangelo , Pauline Ho , Nina Harawa , Peter Kerndt , Janis V. Giorgi , Jiexin Bai , Paula Gaut , Douglas D. Richman , Susan Mandel , Stephen Nichols , and Diagnosing Primary HIV Infection Christopher D. Pilcher , David Alain Wohl , and Charles B. Hicks Metrics 19 March 2002Volume 136, Issue 6Page: 488-489KeywordsAntigensEnzymesHIV clinical manifestationsHIV infections ePublished: 19 March 2002 Issue Published: 19 March 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...