tbuckley/cabot-search huggingface dataset:
Mechanisms of lymphocytotoxicity induced by extracorporeal photochemotherapy for cutaneous T cell lymphoma.
Authors: D I Marks, S P Rockman, M A Oziemski, R M Fox
Journal: Journal of Clinical Investigation (1990)

Extracorporeal photochemotherapy is an effective treatment for cutaneous T cell lymphoma but its mode of action is uncertain. The reduction in viability of patients' photoirradiated buffy coat lymphocytes was correlated with a 35% increase in DNA single-strand breaks and marked decreases in cellular ATP and NAD levels (to 58 and 34% of control, respectively) immediately after photoirradiation. Complementary in vitro studies were conducted with normal human peripheral blood lymphocytes using a Therakos ultraviolet A (UVA) light box. UVA light was cytotoxic on its own but was potentiated by 8-methoxysporalen. 3-aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, mitigated the cytotoxic effect of ultraviolet A light in the presence of 8-methoxypsoralen in lymphocytes and reduced the amount of nucleotide depletion they caused. 10 J/cm2 of UVA light in the presence of 300 ng/ml 8-methoxypsoralen increased the poly (ADP-ribose) synthetase activity of peripheral blood lymphocytes. Exposing lymphocytes to deoxycoformycin and deoxyadenosine was found to induce biochemical and physical effects similar to those of photochemotherapy. In summary, we have shown that the lymphocytotoxic effect of extracorporeal photochemotherapy for cutaneous T cell lymphoma is apparently mediated by DNA damage, subsequent poly (ADP-ribosyl)ation and adenine nucleotide depletion. It is not known how the DNA damage and resultant biochemical effects relate to the possible immunological mechanism of extracorporeal photochemotherapy; however, it is possible that its effects can be mimicked by other DNA-damaging agents.
Early-life prevention of non-communicable diseases
Authors: John M Balbus, Robert Barouki, Linda S Birnbaum, Ruth A Etzel, Peter D Gluckman, Philippe Grandjean, Christine Hancock, Mark A Hanson, Jerrold J Heindel, Kate Hoffman, Génon K Jensen, Ann Keeling, Maria Neira, Cristina Rabadán-Diehl, Johanna Ralston, Kwok-Cho Tang
Journal: The Lancet (2013)
National Medical Response to Mass Disasters in the United States
Authors: Ernesto A. Pretto
Journal: JAMA (1991)

Preparing for a resuscitation response to mass disasters, such as major earthquakes or industrial disasters, requires revisions of present local, regional, and national disaster plans. These should include the following: (1) life-supporting first aid and basic rescue capability of the lay public; (2) advanced trauma life support and advanced (heavy) rescue capability brought quickly to the scene from local and surrounding (regional) emergency medical services systems; and (3) trauma hospitals sending medical resuscitation teams to, and receiving casualties from, the disaster scene for resuscitative surgery and definitive care. Local and regional everyday emergency medical services systems would respond first. The armed forces should help, at least for transport and security. We propose that the National Disaster Medical System replace its civil defense model with an emergency medical services model, designed to mobilize rapid support for local emergency medical services systems from regional, state, and national resources. Coordination should be by one federal agency, such as the Federal Emergency Management Agency, which, however, needs to focus more on resuscitation through physician input.
LIVER UPTAKE OF BONE SEEKING RADIOPHARMACEUTICALS
Authors: S. white, D. Cox, M. Eklem, E. Kingston, M. Mesgarzadeh, H. Smith, H. Sawyer, E. Westcott
Journal: Clinical Nuclear Medicine (1982)

white, S.; Cox, D.; Eklem, M.; Kingston, E.; Mesgarzadeh, M.; Smith, H.; Sawyer, H.; Westcott, E. Author Information
Microbial stimulation as an aetiologic factor in atopic disease
Authors: P. G. Holt, C. Macaubas, S. L. Prescott, P. D. Sly
Journal: Allergy (1999)

Epidemiologic evidence from various sources suggests that exposure to microbial stimuli during early childhood can influence the induction and expression of atopic diseases, particularly in the respiratory tract. Moreover, these effects may have long-lasting consequences in relation to expression of the atopic phenotype in adulthood. This review discusses key aspects of this evidence in relation to the underlying mechanisms which regulate T-helper (Th)-cell function; in particular, the generation of Th-memory cells responsive to inhalant allergens.
Risks of Long-Acting Beta-Agonists in Achieving Asthma Control
Authors: Jeffrey M. Drazen, Paul M. O'Byrne
Journal: New England Journal of Medicine (2009)

In early December 2008, the Food and Drug Administration (FDA) held an unusual joint meeting of the Pulmonary–Allergy Drugs Advisory Committee, the Drug Safety and Risk Management Advisory Committee, and the Pediatric Advisory Committee to consider the safety of long-acting beta-agonists (LABAs). The meeting is described in detail in a Perspective in this issue of the Journal by Kramer,1 who points out that decision making by the advisers and the FDA was hampered by the lack of data about the safety of LABAs.LABAs, which are administered by inhalation, act by effecting prolonged stimulation of the β2-adrenergic receptor. . . .
Elevated IgE and atopy in patients treated for early-onset ADA-SCID
Authors: Monica G. Lawrence, John S. Barber, Robert A. Sokolic, Elizabeth K. Garabedian, Avanti N. Desai, Michelle O'Brien, Nina Jones, Pawan Bali, Michael S. Hershfield, Kelly D. Stone, Fabio Candotti, Joshua D. Milner
Journal: Journal of Allergy and Clinical Immunology (2013)
Low dose of nitroglycerin failed to improve splanchnic hemodynamics in patients with cirrhosis: Evidence for an impaired cardiopulmonary baroreflex function
Authors: Richard Moreau, Dominique Roulot, Alain Braillon, Christophe Gaudin, Antoine Hadengue, Yannick Bacq, Didier Lebrec
Journal: Hepatology (1989)

High doses of nitroglycerin may decrease portal pressure in patients with cirrhosis with untoward effects such as arterial hypotension and a decrease in systemic O2 uptake. In the present study, low doses of nitroglycerin (7 to 15 μg per min, i.v.) were administered in 11 patients with cirrhosis in order to unload cardiopulmonary baroreceptor—one of the possible mechanisms by which nitroglycerin may improve splanchnic hemodynamics—and moreover to avoid deleterious systemic effects. Nitroglycerin significantly decreased right atrial pressure (-35%) and pulmonary wedged pressure (-27%) with significant increase in plasma norepinephrine concentration (+23%), which indicated that cardio-pulmonary baroreceptor unloading was achieved. Changes in systemic hemodynamics were slight, although significant, with a decrease in arterial pressure (-8%) and an increase in heart rate (+8%); this indicates a minimal effect on high-pressure baroreflexes. In contrast, no significant change was observed in hepatic venous pressure gradient, hepatic blood flow and azygos blood flow. However, the fraction of cardiac output reaching the azygos system significantly increased by 18%. Plasma renin activity did not change significantly. Moreover, O2 transport and uptake were significantly decreased. These findings show that low doses of nitroglycerin failed to improve splanchnic hemodynamics in patients with cirrhosis. These results suggest an impaired cardiopulmonary baroreflex function which is probably located on the efferent arch.
Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma
Authors: James R. Cerhan, Stephen M. Ansell, Zachary S. Fredericksen, Neil E. Kay, Mark Liebow, Timothy G. Call, Ahmet Dogan, Julie M. Cunningham, Alice H. Wang, Wen Liu-Mares, William R. Macon, Diane Jelinek, Thomas E. Witzig, Thomas M. Habermann, Susan L. Slager
Journal: Blood (2007)
A Survey of Drug-Induced Extrapyramidal Reactions
Authors: Frank J. Ayd
Journal: JAMA (1961)

Among 3,775 patients treated with tranquilizers of the phenothiazine group, 1,472 developed extrapyramidal reactions; 21.2% had akathisia, 15.4% parkinsonism, and 2.3% dyskinesia. There was correlation between the absolute frequency of these reactions and the chemical structure and milligram potency of the phenothiazine derivative used. Akathisia and parkinsonism occurred twice as often in women as in men, but dyskinesia happened twice as often in men. Dyskinesia was most prevalent between ages 5 and 45, akathisia between 12 and 65, and parkinsonism between 15 and 80. Dyskinesia occurred the earliest, akathisia next, and parkinsonism last in the course of treatment. These reactions appeared only in neurologically susceptible patients. A close parallel was found between drug-induced and naturally occurring extrapyramidal reactions. Drug-induced striopallidal symptoms can be adequately treated with antiparkinsonian drugs.
Alcohol and Aggression
Authors: Donald W. Goodwin
Journal: JAMA (1986)

Buyers of this book may start with the good intention of reading it from cover to cover, but, after a few pages, will probably abandon the idea. The book manages to be slender and ponderous at the same time and has a pronounced numbing effect. By the last pages, the editor (who<i>had</i>to read the book from cover to cover) is showing definite signs of flagging. "Aggression," he says on page 212, "is by no means a heterogenous entity." He clearly means to say that aggression<i>is</i>a heterogenous entity. Actually, he doesn't mean to say that either. On page 1, he says aggression is not an entity but a concept. Anyway, if the book has a single theme, it is that aggression has diverse origins and consequences. The editor has a terrible time defining aggression and finally settles for someone else's definition: "the attempt to deliver noxious stimuli."
Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.
Authors: U K Saarialho-Kere, S O Kovacs, A P Pentland, J E Olerud, H G Welgus, W C Parks
Journal: Journal of Clinical Investigation (1993)

We reported that interstitial collagenase is produced by keratinocytes at the edge of ulcers in pyogenic granuloma, and in this report, we assessed if production of this metalloproteinase is a common feature of the epidermal response in a variety of wounds. In all samples of chronic ulcers, regardless of etiology, and in incision wounds, collagenase mRNA, localized by in situ hybridization, was prominently expressed by basal keratinocytes bordering the sites of active re-epithelialization indicating that collagenolytic activity is a characteristic response of the epidermis to wounding. No expression of mRNAs for 72- and 92-kD gelatinases or matrilysin was seen in keratinocytes, and no signal for any metalloproteinase was detected in normal epidermis. Immunostaining for type IV collagen showed that collagenase-positive keratinocytes were not in contact with an intact basement membrane and, unlike normal keratinocytes, expressed alpha 5 beta 1 receptors. These observations suggest that cell-matrix interactions influence collagenase expression by epidermal cells. Indeed, as determined by ELISA, primary cultures of human keratinocytes grown on basement membrane proteins (Matrigel; Collaborative Research Inc., Bedford, MA) did not express significant levels of collagenase, whereas cells grown on type I collagen produced markedly increased levels. These results suggest that migrating keratinocytes actively involved in re-epithelialization acquire a collagenolytic phenotype upon contact with the dermal matrix.
Left Ventricular Hypertrophy in Men with Normal Blood Pressure: Relation to Exaggerated Blood Pressure Response to Exercise
Authors: John S. Gottdiener
Journal: Annals of Internal Medicine (1990)

To determine whether normal, nonhypertensive subjects who have unusually large increases of systolic blood pressure with exercise have left ventricular hypertrophy (LVH).Case-comparison using echocardiography as a criterion standard for measurement of left ventricular mass and the diagnosis of LVH.Population-based health fitness screening program and referral Veterans Affairs Hospital.Thirty-nine men (average age, 44.6 +/- 8.5 years; range, 34 to 71 years) were studied, including 25 participants in a health fitness screening program and an additional 14 normal men with atypical chest pain. Twenty-two subjects with a systolic blood pressure during peak exercise of 210 mm Hg or greater were compared with 17 others with systolic pressure less than 210 mm Hg during exercise.Left ventricular hypertrophy (left ventricular mass index greater than 134 g/m2) was found in 14 of 22 men with a systolic blood pressure of 210 mm Hg or greater (present in 6.3% of normotensive healthy male volunteers in a health screening program) but in only 1 person with a lower exercise blood pressure. Left ventricular mass index was linearly correlated (r = 0.65, n = 39, P less than 0.001) with maximum exercise blood pressure. Whereas LVH was mild in about 50%, substantial LVH was present in the others. The presence of LVH was not related to superior physical conditioning and was accompanied by increased left atrial size suggesting impaired left ventricular filling.Even in the absence of hypertension, exaggerated blood pressure responses during exercise testing suggest a probability of 0.64 (95% CI, 0.41 to 0.83) of LVH, a finding associated with the cardiac "end-organ" manifestations of hypertension.
A Biopsy That Sticks With Evidence
Authors: P. Marco Fisichella
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
626. Inactivated Sendai Virus Particle (HVJ-E) Solely Induces Specific Anti-Tumor Immune Response and Eradicates Murine Carcinoma
Authors: Masayuki Kurooka, Yasufumi Kaneda
Journal: Molecular Therapy (2006)

Inactivated Sendai virus particle (Hemagglutinating virus of Japan envelope, HVJ-E) has been developed as a safe and efficient non- viral vector for gene delivery system. Now, we discovered that empty HVJ-E solely could induce specific anti-tumor immune response and eradicated growing tumors in mice. In this study, we show that drastic anti-tumor effect by HVJ-E and delineate its characteristic mechanisms by which specific anti-tumor immunity is induced. When HVJ-E was injected into growing tumors of murine colon carcinoma (CT26) in syngeneic Balb/c mice, 60-80% of these tumors were eradicated completely and the remainder was also vigorously inhibited in growth. In addition, the tumorigenicity was diminished as from 80% to 20% in simultaneously inoculated grafts on the distant opposite side. It was convinced that the mechanism by which HVJ-E eradicated CT26 tumors was T cell mediated since this effect was abrogated when CT26 was inoculated to severe combined immuno-deficient (SCID) mice. Re-challenged tumors were also rejected after tumor eradication by HVJ-E treatments. In vitro experiments, murine myelogenic dendritic cell (mDC) was maturated with expressing CD86 or CD40 and releasing cytokines by HVJ-E in the dose dependent manner. Real-time quantitative RT-PCR analysis revealed that significant increasing of CD11c, CD4 and CD8 expressions in HVJ-E treated tumors in vivo. And CT26 specific cytotoxic T lymphocyte (CTL) was effectively induced by HVJ-E treatment in mice. Moreover, in case HVJ-E was used as an adjuvant of chemotherapy, it enhanced and reinforced the anti-cancer effect of Cis-diamminedichloroplatinum (CDDP) in animal models. Finally, we have confirmed that human DC was responded by HVJ-E similarly like murine DC. With putting all these findings together, HVJ-E solely can induce vigorous cellular anti-tumor immune response and eradicate tumors effectively. HVJ-E thus emerges as a favorable and promising novel therapeutics for cancer treatment.
Platelet llb/llla blockade with integrelin: Atherectomy patients
Authors: Paul S. Teirstein, Steven J. Yakubov, Mark C. Thei, Nancy Wildermann, Dean J. Kereiakes, Jeffrey J. Popma, Michael A. Lincoff, James E. Tcheng, Robert M. Califf, Eric J. Topol
Journal: Journal of the American College of Cardiology (1996)
Management of Brown Recluse Spider Bite
Authors: Richard S. Berger
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The dramatic event of severe cutaneous necrosis following brown recluse spider bites has prompted a variety of therapeutic trials. Unfortunately, single reports of successful prevention of necrotic arachnidism can be very misleading.<sup>1</sup>As reported inThe Journal,<sup>2</sup>many of the documented bites produce only erythema and edema or mild hemorrhage and negligible necrosis. The unremarkable bites are most likely caused by small envenomations or protective immunity resulting from previous bites. In lesions destined to go on to significant necrosis, bullae and hemorrhage are usually evident by 24 hours, and a pale, demarcated area is often present at 48 hours. In severe reactions, systemic symptoms begin around 36 hours and include morbilliform rash, urticaria, fever, nausea and vomiting, and occasional hemolysis or diffuse intravascular coagulation. The description of the site at 48 hours in the case report entitled "Dapsone Treatment of a Brown Recluse Bite"<sup>3</sup>
Changes in occlusion pressure (P0.1) and breathing pattern during pressure support ventilation
Authors: P.-F. O Perrigault, Y. H Pouzeratte, S. Jaber, X. J Capdevila, M. Hayot, G. Boccara, M. Ramonatxo, P. Colson
Journal: Thorax (1999)

The purpose of this study was to investigate changes in breathing pattern, neuromuscular drive (P0.1), and activity of the sternocleidomastoid muscles (SCM) during a gradual reduction in pressure support ventilation (PSV) in patients being weaned off controlled mechanical ventilation.Eight non-COPD patients recovering from acute respiratory failure were included in this prospective interventional study. All patients were unable to tolerate discontinuation from mechanical ventilation. Each patient was evaluated during a period of spontaneous breathing and during PSV. Four successive levels of PSV were assessed in the following order: 20 cm H2O (PS20), 15 cm H2O (PS15), 10 cm H2O (PS10), and 5 cm H2O (PS5).When pressure support was reduced from PS20 to PS10 the respiratory rate (f) and the rapid shallow breathing index (f/VT) significantly increased and tidal volume (VT) significantly decreased. These parameters did not vary when pressure support was reduced from PS10 to PS5. Conversely, P0.1 varied negligibly between PS20 and PS15 but increased significantly at low PSV levels. P0.1 values were always greater than 2.9 cm H2O (4.1 (1.1) cm H2O) when SCM activity was present. When contraction of the SCM muscles reappeared the P0.1 was the only parameter that changed significantly.In postoperative septic patients the value of P0.1 seems to be more useful than breathing pattern parameters for setting the optimal level of pressure assistance during PSV.
A unique role for the hippocampus in recollecting the past and remembering the future
Authors: Valerie A. Carr, Indre V. Viskontas
Journal: Behavioral and Brain Sciences (2007)

Abstract Suddendorf &amp; Corballis (S&amp;C) argue that episodic memory is the most flexible and recently evolved memory system, and point to the reorganization of prefrontal cortex throughout human evolution as the neuroanatomical substrate. Their approach, however, fails to address the unique role that the hippocampus, a primitive brain region, plays in creating and recalling episodic memories, as well as future event construction.
Effect of Salt Restriction on Experimental Nephrosis
Authors: Walter Kempner
Journal: JAMA (1965)

AN EFFICIENT and dependable method to produce a nephrotic syndrome experimentally has been developed, in which young rats are subcutaneously injected with aminonucleoside of puromycin. The animals have proteinuria, hypercholesterolemia, and edema, largely as free fluid in the peritoneal cavity and as gel in the skin. The disease can easily be made so severe that most of the animals die within one to three weeks after the injections.<sup>1-3</sup> Steroids did not modify the disease once it had appeared nor did they prevent it from appearing.<sup>4</sup>Adenine (6-aminopurine), but not adenosine, temporarily delayed the onset of proteinuria, but by the second week the nephrotic syndrome was fully developed.<sup>5</sup> Our report deals with the death rate in this experimental nephrosis in the presence and absence of sodium chloride. In a typical experiment which may serve as an example, two groups of twenty rats each were used; they were female
Diagnosis of Fat Emboli
Authors: J. Marc Vedrinne, Christian Guillaume, M. Claire Gagnieu
Journal: Annals of Internal Medicine (1991)

Letters15 February 1991Diagnosis of Fat EmboliJ. Marc Vedrinne, MD, Christian Guillaume, MD, M. Claire Gagnieu, MDJ. Marc Vedrinne, MDSearch for more papers by this author, Christian Guillaume, MDSearch for more papers by this author, M. Claire Gagnieu, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-4-339_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:We read with interest the recent article by Chastre and colleagues (1) on the rapid diagnosis of the fat embolism syndrome in patients with trauma. The fat embolism syndrome is difficult to diagnose clinically, and the identification of fat droplets within cells recovered by bronchoalveolar lavage has been purported to provide a sensitive and specific means for rapid diagnosis. Since January 1990, we used and evaluated a similar technique. After cytocentrifugation on bronchoalveolar lavage recovery, we stained alveolar macrophages with red oil, a specific stain for neutral fat. The percentage of alveolar macrophages containing intracellular fat droplets...Reference1. Chastre J, Fagon J, and Soler P. Bronchoalveolar lavage for rapid diagnosis of the fat embolism syndrome in trauma patients. Ann Intern Med. 1990;113:583-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. Marc Vedrinne, MD; Christian Guillaume, MD; M. Claire Gagnieu, MDAffiliations: Hôpital Edouard Herriot Lyon Cedex 03 France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiseases of the Blood Vessels 15 February 1991Volume 114, Issue 4Page: 339-339KeywordsAdipocytesBronchoalveolar lavageCellsFatsMacrophagesOils ePublished: 1 December 2008 Issue Published: 15 February 1991 PDF downloadLoading ...