tbuckley/cabot-search huggingface dataset:
Mortality of rheumatoid arthritis in Japan: a longitudinal cohort study
Authors: M Hakoda
Journal: Annals of the Rheumatic Diseases (2005)

<b>Objective:</b> To determine the mortality risk of Japanese patients with rheumatoid arthritis, taking into account lifestyle and physical factors, including comorbidity. <b>Methods:</b> 91 individuals with rheumatoid arthritis were identified during screening a cohort of 16 119 Japanese atomic bomb survivors in the period 1958 to 1966. These individuals and the remainder of the cohort were followed for mortality until 1999. Mortality risk of the rheumatoid patients was estimated by the Cox proportional hazards model. In addition to age and sex, lifestyle and physical factors such as smoking status, alcohol consumption, blood pressure, and comorbidity were included as adjustment factors for the analysis of total mortality and for analysis of mortality from each cause of death. <b>Results:</b> 83 of the rheumatoid patients (91.2%) and 8527 of the non-rheumatoid controls (52.9%) died during mean follow up periods of 17.8 and 28.0 years, respectively. The age and sex adjusted hazard ratio for mortality in the rheumatoid patients was 1.60 (95% confidence interval, 1.29 to 1.99), p&lt;0.001. Multiple adjustments, including for lifestyle and physical factors, resulted in a similar mortality hazard ratio of 1.57 (1.25 to 1.94), p&lt;0.001. Although mortality risk tended to be higher in male than in female rheumatoid patients, the difference was not significant. Pneumonia, tuberculosis, and liver disease were significantly increased as causes of death in rheumatoid patients. <b>Conclusions:</b> Rheumatoid arthritis is an independent risk factor for mortality. Infectious events are associated with increased mortality in rheumatoid arthritis.
Sequence of shortening of the normal human left ventricle
Authors: E. A. NOGUEIRA, S. S. CARVALHAL, P. A. R. JORGE, L. A. K. BITTENCOURT, R. G. G. TERZI
Journal: Cardiovascular Research (1979)

Journal Article Sequence of shortening of the normal human left ventricle Get access EDUARDO A. NOGUEIRA, EDUARDO A. NOGUEIRA 1 From the Department of Medicine, Division of Cardiology, University of Campinas School of Medicine, Campinas, São Paulo, Brazil 1Address for reprints: Dr E. A. Nogueira, Rua Pelágio Lôbo 72, 13.100 Campinas, São Paulo, Brazil. Search for other works by this author on: Oxford Academic PubMed Google Scholar SILVIO S. CARVALHAL, SILVIO S. CARVALHAL From the Department of Medicine, Division of Cardiology, University of Campinas School of Medicine, Campinas, São Paulo, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar PAULO A. R. JORGE, PAULO A. R. JORGE From the Department of Medicine, Division of Cardiology, University of Campinas School of Medicine, Campinas, São Paulo, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar LUIZ A. K. BITTENCOURT, LUIZ A. K. BITTENCOURT From the Department of Medicine, Division of Cardiology, University of Campinas School of Medicine, Campinas, São Paulo, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar RENATO G. G. TERZI RENATO G. G. TERZI From the Department of Medicine, Division of Cardiology, University of Campinas School of Medicine, Campinas, São Paulo, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 13, Issue 12, December 1979, Pages 703–710, https://doi.org/10.1093/cvr/13.12.703 Published: 01 December 1979
MENTAL HEALTH AS A NATIONAL PROBLEM
Authors: RAY LYMAN WILBUR
Journal: JAMA (1931)

Probably one of the highest compliments that can be given is to say that a man has good common sense, or to say that the people of a nation are sane and stable. All recognize to some degree the eternal conflicts between the emotions and the intelligence. These conflicts may be seasonal. They are associated with certain periods of life and they are fundamental in determining one's happiness, achievements and personality. From a national standpoint there is the most persistent evidence of the interrelations and interplay between intelligence and emotions. Human behavior in the mass determines our successes or our failures as a nation. Politically, many of us at all times, and all of us at some times, act like the proverbial college sophomore. As an observing senator has said: "Our greatest safety is our organization by states, for not more than a dozen states are apt to go haywire
CASE OF CHOLERA IN WHICH RECOVERY TOOK PLACE
Authors: A. Hill
Journal: BMJ (1854)

er opetion.Wer it resorted to more generally in hopeles of reovery, on the principle of prolonging le, our efforts would very soon be directed to learn the best mode of operating, as respects the quantity of fluid to be introduced, the nature of the fluid, the times at which it might be repeated, etc., with a view to obtain the utmost prolongation of life possible: and I am sanguine enough to believe that the accuracy of observation which this would induce must lead to important results in relation to the cure of the disease.The primary object, as respects this operation, is to discover the proper remedy for the collapse, taking care that the effects of such remedy shall not be in- compatible with recoveryfrom the disease, and the restoration of the patient to health.Viewiing a patient in the most ex- treme stateof collapsefrom cholera, it should al ways be borne in mind that in such a patient, until life is extinct, there does not neceflarity exist any disorganisation totally inconsistent with recovery.Finally, I have seen a man pulseless, speechless, cold, and livid, rise up in bed and converse, after -the injection of a saline fluid into the blood, and remain for several hours capable of declaring his last wishes to those around him, or of taking his farewell of the world, of forgiv- ing or beino forgiven, or, it might be, of making his peace 'With his God.3 N~orfolk Crescent, August 21st., 18&4.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
Authors: Yun-Hee Youm, Kim Y Nguyen, Ryan W Grant, Emily L Goldberg, Monica Bodogai, Dongin Kim, Dominic D'Agostino, Noah Planavsky, Christopher Lupfer, Thirumala D Kanneganti, Seokwon Kang, Tamas L Horvath, Tarek M Fahmy, Peter A Crawford, Arya Biragyn, Emad Alnemri, Vishwa Deep Dixit
Journal: Nature Medicine (2015)
Octogenarian Chain Smokers
Authors: Walter J. Burdette
Journal: JAMA (1965)

<h3>To the Editor:—</h3> TheQuestions and Answerssection of the April 19 issue ofThe Journal(<b>192</b>:269) cited an observation of mine concerning a lower mortality ratio of octogenarian smokers of 40+ cigarettes daily, compared to their nonsmoking cronies. I was intrigued by the commentary provided by the eminent surgeon-scientist, Walter J. Burdette, MD, who was a member of the Advisory Committee to the Surgeon General of the Public Health Service, and was in some part responsible for the famous report on "Smoking and Health" (Public Health Service publication No. 1103, undated, p 387). I was dismayed to learn that the size of the sample which produced a listed mortality ratio of 0.58 (Table 6, p 387) was far too small to have been of any significance; only eight ninth-decade toughies burned up more than 40 tailor-mades daily. Although I searched the report for some indication of the number
REDUCED LUNG FUNCTION PREDICTS THE DEVELOPMENT OF ATRIAL FIBRILLATION IN OLDER ADULTS: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS-LUNG STUDY
Authors: Harjit Chahal, R. Graham Barr, Susan Heckbert, David Bluemke, Mohammadali Habibi, Alvaro Alonso, Richard Kronmal, David Jacobs, Kiang Liu, Joao Lima, Karol Watson, Lewis J. Smith, Philip Greenland
Journal: Journal of the American College of Cardiology (2014)
Phase II Study of Carboplatin, Paclitaxel, and Bevacizumab With Maintenance Bevacizumab As First-Line Chemotherapy for Advanced Müllerian Tumors
Authors: Richard T. Penson, Don S. Dizon, Stephen A. Cannistra, Maria R. Roche, Carolyn N. Krasner, Suzanne T. Berlin, Neil S. Horowitz, Paul A. DiSilvestro, Ursula A. Matulonis, Hang Lee, Modjulie A. King, Susana M. Campos
Journal: Journal of Clinical Oncology (2009)

Purpose New strategies are needed to improve outcomes for patients with advanced ovarian cancer. Bevacizumab is a recombinant humanized monoclonal antibody that neutralizes vascular endothelial growth factor but is associated with GI perforations (GIPs) in patients with recurrent disease. Patients and Methods An open-label, phase II clinical trial was conducted in newly diagnosed patients with stage ≥ IC epithelial müllerian tumors. Patients received intravenous (IV) carboplatin (area under the curve = 5), paclitaxel (175 mg/m 2 IV), and bevacizumab (15 mg/kg IV) for six to eight cycles on day 1 every 21 days. Bevacizumab was omitted in the first cycle and continued as a single agent for 1 year. Results Sixty-two women participated in this study. Fifty-one patients (82%) were optimally surgically cytoreduced before treatment. The median age was 58 years (range, 18 to 77 years). Forty-five women (73%) had ovarian cancer, 10 (16%) had peritoneal cancer, four (6%) had fallopian tube cancers, and three (5%) had uterine papillary serous tumors. The majority of patients (90%) had stage III or IV disease. A median of 17 maintenance cycles (range, 0 to 25+ cycles) of bevacizumab (556 cycles) were administered with mild toxicity. Treatment was associated with two pulmonary embolisms and two GIPs, all occurring during the chemotherapy phase of treatment (364 total cycles). No grade 4 toxicities were seen during maintenance bevacizumab treatment. Radiographic responses were documented in 21 (75%) of 28 women with measurable disease (11 complete responses and 10 partial responses), with CA-125 responses in 76% of patients (11 complete responses, 21%; and 35 partial responses, 55%). The progression-free survival rate at 36 months was 58%. Conclusion The regimen of carboplatin, paclitaxel, and bevacizumab with maintenance bevacizumab is feasible, safe, and worthy of future study in advanced ovarian cancer.
Clinical Application of Indicator Dilution Curves.
Authors: P. N. Yu
Journal: Annals of Internal Medicine (1961)

s1 May 1961Clinical Application of Indicator Dilution Curves.P. N. Yu, M.D., F.A.C.P.P. N. Yu, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1041_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis paper reviews our experience in the use of arterial and precordial indicator dilution curves inscribed in over 500 cardiac patients. It also presents some of the newer developments in theoretical aspects and experimental studies concerning indicator dilution technic in the diagnosis of various types of cardiovascular lesions.In congenital heart disease, within certain limitations, the indicator dilution curve is reliable to detect left-to-right shunts and to localize right-to-left shunts. Patterns of the indicator dilution curves in various types of valvular heart disease may be predicted with reasonable accuracy according to the nature, site, and degree of the lesion and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, N. Y. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1041-1042KeywordsCardiovascular therapyCongenital heart diseaseLesions ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Antigen Detection in Fungal Infections
Authors: David J. Drutz
Journal: New England Journal of Medicine (1986)

In the management of a suspected fungal infection, no diagnostic test is superior to the isolation of the causative agent from a relevant clinical specimen, or to its unequivocal physical identification in a histopathological setting of tissue invasion. These ideal situations are achieved only occasionally, however, so one often must employ diagnostic approaches that are based on serologic testing. In two situations, serologic testing is so reliable that a positive test, even if the titer is low, is generally indicative of infection with a specific etiologic agent. Thus, the demonstration of antibodies to Coccidioides immitis in the cerebrospinal fluid by . . .
Publishing performance data is an ethical obligation in all specialties
Authors: S. N. Bolsin, M. Colson
Journal: BMJ (2014)

The article by Westaby dealing with publication of surgical mortality data is at best a superficial examination of the issue and at worst misleading.1 The evidence has been irrefutable for many years that the collection and feedback of risk adjusted mortality data will reduce death rates by as much as 40% in cardiac surgery …
Gallbladder Perforation Seen on Hepatobiliary Imaging Following Morphine Sulfate Injection
Authors: ALBERT J. MORENO, CAROL A. ORTENZO, ANA A. RODRIGUEZ, FRANCIS M. KYTE, GOTTLIEB L. TURNBULL
Journal: Clinical Nuclear Medicine (1989)

A case of gallbladder perforation imaged during morphine-augmented cholescintigraphy is presented. Tc-99m DISIDA imaging dramatically demonstrated the bile leak. Whether morphine sulfate contributed to the perforation of the gallbladder is debatable.
Who will benefit from hyposensitization?
Authors: H. Mosbech
Journal: Allergy (1990)

The aim of this study was to assess the ability of various data collected before treatment to predict the therapeutic benefits of hyposensitization. Thirty‐one asthmatics were hyposensitized with extract from the house dust mite Dermalophagoides pteronyssinus (Dp) for 2 years, 15 comparable patients served as controls. The treatment extract was either modified by coupling to monomethoxypolyethylene glycol (mPEG) or administered in a diluent containing A1(OH) 3 . Improvement would be either a 2? 10‐fold increase in bronchial tolerance to Dp or an overall clinical effect judged from questionnaires plus diary cards. Patients improving in bronchial Dp‐sensitivity after 1 year had been more sensitive to Dp pre‐treatment in bronchi and in basophils, and had a lower FEV 1 , compared with the patients not improving ( P &lt;0.05). Occurrence of late‐phase bron‐chospasm to pre‐treatment Dp‐challenge increased the chance of clinical improvement approximately 3‐fold ( P &lt; 0.05). A certain mite exposure seems to be a condition of an improvement in symptoms/medication. In patients improving, the median allergen concentration on mattresses was equivalent to 1,000 mites/g compared with &lt; 250 mites/g in patients showing no clinical improvement ( P = 0.1). Information on Dp‐specific IgE, IgG, IgG subclasses, Dp‐sensitivity in skin, nose and eyes, age, and duration of symptoms did not permit any prediction of therapeutic effect.
Preoperative Echocardiography for Noncardiac Surgery
Authors: Ted Palen
Journal: Annals of Internal Medicine (1997)

Letters1 June 1997Preoperative Echocardiography for Noncardiac SurgeryTed Palen, MD, PhDTed Palen, MD, PhDUniversity of Colorado Health Sciences Center, Denver, CO 80220Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-11-199706010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I commend Dr. Halm and his colleagues in the Study of Perioperative Ischemia Research Group for giving us valuable insight into the role of echocardiography in preoperative evaluations [1]. The comprehensive tables documenting the sensitivity, specificity, and predictive values of ejection fractions from echocardiograms illustrate that high technology is not always better than a thorough history and physical. However, I was disappointed that the authors did not delineate the manner in which information from the traditional clinical evaluation was incorporated into their clinical model. The authors state that several risk classification schemes were determined for each patient, ...References1. Halm EA, Browner WS, Tubau JF, Tateo IM, Mangano DT. Echocardiography for assessing cardiac risk in patients having noncardiac surgery. Study of Perioperative Ischemia Research Group. Ann Intern Med. 1996; 125:433-41. Google Scholar2. Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray DS, et al. Multifactorial index of cardiac risk in noncardiac surgical procedures. N Engl J Med. 1977; 297:845-50. Google Scholar3. Detsky AS, Abrams HB, McLaughlin JR, Drucker DJ, Sasson Z, Johnston N, et al. Predicting cardiac complications in patients undergoing non-cardiac surgery. J Gen Intern Med. 1986; 1:211-9. Google Scholar4. Criteria Committee of the New York Heart Association. Nomenclature and Criteria for the Diagnosis of Diseases of the Heart and Great Vessels. v 94. Boston: Little, Brown; 1979. Google Scholar5. American Society of Anesthesiologists. New classification of physical status. Anesthesiology. 1963; 24:111. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Colorado Health Sciences Center, Denver, CO 80220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1997Volume 126, Issue 11Page: 919KeywordsEchocardiographyEjection fractionIschemiaSpecificitySurgery Issue Published: 1 June 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Clinical Problems of Thyrotoxicosis
Authors: P. McEwan
Journal: BMJ (1938)

Among the many interesting problems of thyrotoxicosis there is none more urgent and more obscure than the high and rapidly increasing death rate.During the year 1936 no fewer than 1,696 deaths were attributed to that con- dition in England and Wales.There has been a steady rise for many years, the exact figures being: Year .. .
Eosinophils, Pleural Effusions, and Malignancy
Authors: STANLEY C. DERESINSKI
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 September 1978Eosinophils, Pleural Effusions, and MalignancySTANLEY C. DERESINSKI, M.D.STANLEY C. DERESINSKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-3-424_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The concise review of malignant pleural effusion by Leff, Hopewell, and Costello (1) was a delight to read. I would, however, like to comment on their statement that "eosinophils are absent" from such effusions.The reference given by the authors for this assertion states only that "increased numbers of eosinophils in an effusion suggest infection or infarction" (2). The presence of eosinophils in pleural effusions appears to be a relatively nonspecific finding and by no means eliminates malignant disease as a cause. In three published series, infection was the cause in 10% to 24% of cases while...References1. LEFFHOPEWELLCOSTELLO APJ: Pleural effusion from malignancy. Ann Intern Med 88:532-537, 1978 LinkGoogle Scholar2. ROSATOWALLACHROSATO FME: The management of malignant effusions from breast cancer. J Surg Oncol 6:441-449, 1974 CrossrefMedlineGoogle Scholar3. CAMPBELLWEBB GW: Eosinophilic pleural effusion. Am Rev Respir Dis 90:194-201, 1964 MedlineGoogle Scholar4. KOKKOLAVALTA KR: Aetiology and findings in eosinophilic pleural effusion. Scand J Respir Dis (Suppl) 89:159-165, 1974 MedlineGoogle Scholar5. BOWER G: Eosinophilic pleural effusion. Am Rev Respir Dis 95:746-751, 1967 MedlineGoogle Scholar1. BOWER G: Eosinophilic pleural effusion. Am Rev Respir Dis 95:746-751, 1967 MedlineGoogle Scholar2. CAMPBELLWEBB GW: Eosinophilic pleural effusion. Am Rev Respir Dis 90:194-201, 1964 MedlineGoogle Scholar3. PADDOCK F: The diagnostic significance of serous fluids in disease. TV Engl J Med 223:1010-1015, 1940 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STANLEY C. DERESINSKI, M.D.Affiliations: University of South Florida Medical Center Tampa, FL 33612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPleural fluid dataEosinophilia in Malignant Pleural EffusionJOHN G. MEHARG JR, M.D., SCOTT A. CHERRY, M.D. 1 September 1978Volume 89, Issue 3Page: 424-425KeywordsEosinophilsInfarctionPleural effusion ePublished: 1 December 2008 Issue Published: 1 September 1978 PDF downloadLoading ...
Electrophysiological effects of high cocaine concentrations on intact canine heart. Evidence for modulation by both heart rate and autonomic nervous system.
Authors: C W Clarkson, C Chang, A Stolfi, W J George, S Yamasaki, A S Pickoff
Journal: Circulation (1993)

BACKGROUND Previous clinical reports have suggested that cocaine intoxication may produce severe ventricular arrhythmias due to a direct effect on the heart. However, the effects of high plasma levels of cocaine on the electrophysiology of the heart have not been well characterized and remain poorly understood. METHODS AND RESULTS The purpose of this study was to characterize the electrophysiological effects of high doses of cocaine on the in situ dog heart. In dogs anesthetized with morphine and alpha-chloralose, cocaine (2-11 micrograms/mL) increased both atrial and ventricular refractory periods and produced rate-dependent increases in atrial, atrioventricular, His-Purkinje, and ventricular conduction intervals. The time constant for the onset of cocaine's conduction slowing effect following a reduction in pacing cycle length from 400 to 260 msec was approximately two beats, and the time constant for diastolic recovery from conduction slowing was approximately 200 msec, which are similar to values reported for several class Ib antiarrhythmic drugs. Cocaine produced a rate-dependent increase in QT interval that was greatest at high heart rates yet produced no change in the ST (QT-QRS) interval. This suggests that high plasma levels of cocaine delay repolarization primarily via slowing of conduction. Cocaine's effects on both atrioventricular and intraventricular conduction were significantly larger in autonomically blocked than in autonomically intact animals. CONCLUSIONS We conclude that high plasma levels of cocaine, similar to those reported in autopsy reports following fatal cocaine overdose in humans, produce significant rate-dependent conduction slowing effects on atrial, atrioventricular, and ventricular conduction in the in situ heart. These rate-dependent effects are intensified following autonomic blockade.
Lawsuits for Malpractice
Authors: Adolph Wolferman
Journal: JAMA (1978)

<h3>To the Editor.—</h3> In his article on malpractice (238:861-863, 1977), James M. Vaccarino, JD, is guilty of oversimplification. He lists three main causes of frivolous malpractice suits: poor physician-patient relationship, poor results, and the cost of medical care. He totally ignores the huge rewards of successful malpractice suits for the legal profession; these rewards, combined with the absence of any loss in case the patient loses in court, makes the initiation of a malpractice action an investment without risk for lawyer and patient alike. Nor does Mr Vaccarino mention the jury system that makes a malpractice suit a legal battle where the medical facts are of secondary importance. Mr Vaccarino states, "The most significant contributive factor to frivolous claims is the poor relationship with the provider," that is, the physician-patient relationship. The attitude of the patient is just as important as that of the physician in establishing a good physician-patient