Evidence for the Fundic Origin of Intrinsic Factor
Authors: LAWRENCE D. WRUBLE
Journal: Annals of Internal Medicine (1964)

Case Studies1 May 1964Evidence for the Fundic Origin of Intrinsic FactorAn in Vivo StudyLAWRENCE D. WRUBLE, M.D., G. WILLIAM COLE, M.D., HOWARD E. LESSNER, M.D., F.A.C.P. (ASSOCIATE), S. Z. HENRICK HAIDRI, PH.D., MARTIN H. KALSER, M.D., PH.D., F.A.C.P.LAWRENCE D. WRUBLE, M.D.Search for more papers by this author, G. WILLIAM COLE, M.D.Search for more papers by this author, HOWARD E. LESSNER, M.D., F.A.C.P. (ASSOCIATE)Search for more papers by this author, S. Z. HENRICK HAIDRI, PH.D.Search for more papers by this author, MARTIN H. KALSER, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-5-877 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe site of production of human gastric intrinsic factor has not been conclusively demonstrated. Previous studies have been done with either in vitro (1, 2) or postmortem speciments of human stomachs (3). Although these studies have indicated that most intrinsic factor activity is present in the fundus, with little or none in the antrum, no in vivo confirmatory studies have as yet been reported. A patient with the Zollinger-Ellison syndrome for which a parietal cell mass resection, leaving only the antrum, was to be performed, afforded us an opportunity to delineate in vivo the site of origin of human intrinsic...References1. MEULENGRACHT E: The presence of the anti-anemic factor in preparations of dried stomach substance from the cardia, fundus and pylorus respectively. Acta Med. Scand. 82: 352, 1934. CrossrefGoogle Scholar2. UNGLEY CC: Observations on Castle's intrinsic factor in pernicious anemia. Lancet 1: 1232, 1936. CrossrefGoogle Scholar3. FOXCASTLE HJWB: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. Amer. J. Med. Sci. 203: 18, 1942. CrossrefGoogle Scholar4. WRUBLEBENNETTDAVISMEDLINFARRELLKALSER LDLDJHJJMH: Zollinger-Ellison syndrome: surgical removal of parietal cell mass with preservation of antrum and pylorus, ileocolonic transplant, and resultant achlorhydria. Ann. Surg. 158: 270, 1963. CrossrefMedlineGoogle Scholar5. LOWICKILITTLEFIELD EMJB: An experimental method of precisely defining the dimension of the gastric antrum. Surg. Forum 12: 308, 1961. MedlineGoogle Scholar6. SCHILLINGCLATANOFFKORST RFDVDR: Intrinsic factor studies. II. Further observations utilizing the urinary radioactivity test in subjects with achlorhydria, pernicious anemia, or a total gastrectomy. J. Lab. Clin. Med. 45: 926, 1955. MedlineGoogle Scholar7. SCHILLING RF: Intrinsic factor studies. II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J. Lab. Clin. Med. 42: 860, 1953. MedlineGoogle Scholar8. GLASS GB: Paper electrophoresis of gastric juice in health and disease. Amer. J. Dig. Dis. 6: 1131, 1961. CrossrefMedlineGoogle Scholar9. PIPERSTEILBUILDER DWMCJE: The electrophoresis of human gastric juice. Gut 3: 349, 1962. CrossrefMedlineGoogle Scholar10. CASTLETOWNSEND WBWC: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. II. The effect of the administration to patients with pernicious anemia of beef muscle after incubation with normal human gastric juice. Amer. J. Med. Sci. 178: 764, 1929. CrossrefGoogle Scholar11. MAGNUSUNGLEY HACC: The gastric lesion in pernicious anemia. Lancet 1: 420, 1938. CrossrefGoogle Scholar12. MEULENGRACHT E: Histologic investigation into the pyloric gland organ in pernicious anemia. Amer. J. Med. Sci. 197: 201, 1939. CrossrefGoogle Scholar13. KEUNINGARENDSMANDEMANIEWEY FJAEHO: Observations on the site of production of Castle's intrinsic factor in the rat. J. Lab. Clin. Med. 53: 127, 1959. MedlineGoogle Scholar14. ANDERSONGUNNWATT CDRTJK: Results of partial gastrectomy in treatment of peptic ulcer. Brit. Med. J. 1: 508, 1955. CrossrefMedlineGoogle Scholar15. WELBOURNNELSONZACHARIAS RBMGFJ: Megaloblastic anemia following gastric resection. Brit. J. Surg. 43: 422, 1956. CrossrefMedlineGoogle Scholar16. WELLSMACPHEE CIW: Partial gastrectomy: ten years later. Brit. Med. J. 2: 1128, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAWRENCE D. WRUBLE, M.D.; G. WILLIAM COLE, M.D.; HOWARD E. LESSNER, M.D., F.A.C.P. (ASSOCIATE); S. Z. HENRICK HAIDRI, PH.D.; MARTIN H. KALSER, M.D., PH.D., F.A.C.P.Affiliations: Memphis, TennesseeFrom the Section of Gastroenterology and Hematology, University of Miami, School of Medicine, and the Veterans Administration Hospital, Miami, Florida.Dr. Wruble was formerly a National Institute of Health trainee in gastroenterology, University of Miami Medical School. This training grant was supported by grant T1 AM-5247-04, United States Public Health Service.Requests for reprints should be addressed to Lawrence D. Wruble, M.D., Department of Medicine, University of Tennessee School of Medicine, 858 Madison Avenue, Memphis 3, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistamine-containing epithelial cells in rat stomach: A possible storage site for the intrinsic factor 1 May 1964Volume 60, Issue 5Page: 877-881KeywordsAnemiaHematology and oncologyHospital medicineMedical servicesParietal cellsStomachTransplantationZollinger Ellison syndrome ePublished: 1 December 2008 Issue Published: 1 May 1964 PDF downloadLoading ...