Gram-Positive Infections and Quinolones in Neutropenia
Authors: Elio Castagnola
Journal: Annals of Internal Medicine (1997)

Letters15 May 1997Gram-Positive Infections and Quinolones in NeutropeniaElio Castagnola, MD and Claudio Viscoli, MDElio Castagnola, MDG. Gaslini Children's Hospital, 16147 Genova, ItalyNational Institute for Cancer Research, University of Genova, Genova, ItalySearch for more papers by this author and Claudio Viscoli, MDG. Gaslini Children's Hospital, 16147 Genova, ItalyNational Institute for Cancer Research, University of Genova, Genova, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-10-199705150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent report, Bow and colleagues [1] suggest that prophylaxis with fluoroquinolones and rifampin in neutropenic patients decreases the incidence of gram-negative bacteremias and the overall number of documented infections. However, prophylaxis did not reduce the number of febrile episodes or the use of intravenous antibiotics and did not affect either the final outcome of febrile episodes that occurred despite prophylaxis or the overall mortality rate. Although the statistical power of the observed results is not clear (surprisingly, the manner in which the sample size was calculated was not explained), these results deserve some comments, especially ...References1. Bow EJ, Mandell LA, Louie TJ, Feld R, Palmer M, Zee B, et al. Quinolone-based antibacterial chemoprophylaxis in neutropenic patients: effects of augmented gram-positive activity on infectious morbidity. Ann Intern Med. 1996; 125:183-90. Google Scholar2. Cometta A, Calandra T, Bille J, Glauser MP. Escherichia coli resistant to fluoroquinolone prophylaxis in patients with cancer and neutropenia. N Engl J Med. 1994; 330:1240-1. Google Scholar3. Richard P, Delangle MH, Merrien D, Barille S, Reynaud A, Minozzi C, et al. Fluoroquinolone use and fluoroquinolone resistance: is there an association? Clin Infect Dis. 1994; 19:54-9. Google Scholar4. Viscoli C, Bruzzi P, Castagnola E, Boni L, Calandra T, Gaya H, et al. Factors associated with bacteremia in febrile granulocytopenic cancer patients. Eur J Cancer. 1994; 30:430-7. Google Scholar5. Castagnola E, Lanino E, Garaventa A, Dini G, Dallorso S, Carrega G, et al. Prophylaxis of streptococcal bacteremia with oral penicillin V in children undergoing bone marrow transplantation. Support Care Cancer. 1995; 3:319-21. Google Scholar Author, Article, and Disclosure InformationAuthors: Elio Castagnola, MD; Claudio Viscoli, MDAffiliations: G. Gaslini Children's Hospital, 16147 Genova, ItalyNational Institute for Cancer Research, University of Genova, Genova, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA multicenter, randomized, double blind placebo-controlled trial of amoxicillin/clavulanate for the prophylaxis of fever and infection in neutropenic children with cancerBiocide tolerance and the harbingers of doomPlanned progressive antimicrobial therapy in neutropenic patients 15 May 1997Volume 126, Issue 10Page: 830-831KeywordsAntibioticsAntimicrobial resistanceBacteremiaBacteriaDeath ratesFeversHyperthermiaNeutropeniaPathogensProphylaxis ePublished: 15 August 2000 Issue Published: 15 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...