tbuckley/cabot-search huggingface dataset:
SYSTEMIC LUPUS ERYTHEMATOSUS: A REPORT OF FORTY-FIVE CASES WITH UNUSUAL CLINICAL AND IMMUNOLOGICAL FEATURES
Authors: K. O. WONG
Journal: British Journal of Dermatology (1969)

Journal Article SYSTEMIC LUPUS ERYTHEMATOSUS: A REPORT OF FORTY‐FIVE CASES WITH UNUSUAL CLINICAL AND IMMUNOLOGICAL FEATURES Get access K. O. WONG K. O. WONG Medical and Health Department, Hong Kong Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 3, 1 March 1969, Pages 186–190, https://doi.org/10.1111/j.1365-2133.1969.tb16004.x Published: 01 March 1969 Article history Accepted: 04 July 1968 Published: 01 March 1969
3 ACTIVATED INTESTINAL MACROPHAGES IN LIVER CIRRHOSIS PRODUCE NITRIC OXIDE AND DISRUPT INTESTINAL BARRIER FUNCTION
Authors: J. du Plessis, L. Roos, T. Slavik, P.I. Stivaktas, M. Nieuwoudt, S.G. van Wyk, W.A. Vieira, E. Pretorius, M. Beukes, S.W. van der Merwe
Journal: Journal of Hepatology (2012)
GW25-e5396 The Significance of Plasm Macrophage Migration Inhibitory Factor (MIF) for the Future Risk Evaluation of Major Adverse Cardiac Events in Patients With Acute Myocardial Infarction
Authors: Qiang Zhao, Juan Zhou, Weimin Liu, Ling Zhu, Zhaofei Wan, Dong Zhou, Shanshan Gao, Hongjun You, Peining Liu, Yang Liu, Zuyi Yuan
Journal: Journal of the American College of Cardiology (2014)
Pure Terebene in Winter-Cough
Authors: J. Hutchison
Journal: BMJ (1886)

THE BRITISH MEDICAL JOURNBAL.1i healthy.The mental faculties are perfect.He has no couigh, diar- rhwa, or perspirations; no pyrexia or hedtic.-.REMA1X8S.*-!-The above is a tpical cUel of 'mollities: ots8Wnt.Numerous vieVts have been ad-rnced as to the nature of this diseasd.Trousseau (CUinial Mediin,e, ol ',; ipage &l )aYS: "Ought Fwe to consider that there is a similaTity' between osteo-malaeia and rickets f I say, we onght.Jn my opinion, and in.that of many other phksicians,i they are one and the .same."This opinionj he supports by statements, for which I must refer readers to the jarticle itself; but which, in my experience, are quite contrary to fact.For instance, in the case above described, there ha bWen an entire absence of the constitutional symptoms which are characteristic of rickets: pyrexia, profuse sweats, soreness. of the bones, derangements of thb alimentary tract, and inflammatory affections -of the respiratory organs.Again, in alluding to the occurrencB of fractures in/rickets, he says (Thid, page 81), there is a "greater rarity of fradtures in the rickets of adults than in the rickets of children."This i § quite contrary to my experience ; for, unfortunately, in Preston, rickets is most prevalent, yet I never have seen a case of spontaneous fracture in any out of a very latge, number of cases I have attended.Moreover, rickets is generally traceable to some defin'ite cause, chiefly dietetic; but, in the case described, there is a total inability to discover any predisposing cause.
Abstract IA01: Transcriptional and epigenetic control of oncogenes
Authors: Richard A. Young
Journal: Cancer Research (2013)

Abstract The gene expression program of any particular cell largely defines its identity and its functions. I will describe new insights into the roles that transcription factors and chromatin regulators play in the control of gene expression programs during normal development and in cancer. These insights provide opportunities for the development of novel therapeutics for cancer and other diseases. Citation Format: Richard A. Young. Transcriptional and epigenetic control of oncogenes. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr IA01.
421 Hepatitis C virus (HCV)-specific CD4+ and CD8+ T cell responses in patients with chronic hepatitis C treated with pegylated interferon plus ribavirin
Authors: L. Capa, J. Garcia-Samaniego, V. Soriano, M. Romero, M. Núnez, C. de Mendoza, A. Cascajero, N. Zahonero, E. Muñoz, J. González-Lahoz, J.M. Benito
Journal: Journal of Hepatology (2006)
Role of the stromal-derived factor-1 (SDF-1)–CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma
Authors: Alessandra Gentilini, Krista Rombouts, Sara Galastri, Alessandra Caligiuri, Eleonora Mingarelli, Tommaso Mello, Fabio Marra, Stefano Mantero, Massimo Roncalli, Pietro Invernizzi, Massimo Pinzani
Journal: Journal of Hepatology (2012)
Influence of hypoxia on adrenergic modulation of triggered activity in isolated adult canine myocytes.
Authors: S G Priori, K A Yamada, P B Corr
Journal: Circulation (1991)

Although findings from several reports suggest that nonreentrant or focal mechanisms contribute to the genesis of arrhythmias during early ischemia, the contribution of triggered activity arising from early or delayed afterdepolarizations has not been resolved. We have previously demonstrated that beta- but not alpha-adrenergic stimulation induces afterdepolarizations and triggered activity in isolated normoxic myocytes. In the present study, the influence of the extent of cellular derangements as well as increases in [K+]o on alpha- and beta-adrenergic-mediated afterdepolarizations and triggered activity was evaluated. Adult canine myocytes were exposed to one of the following experimental conditions with simultaneous intracellular transmembrane action potential recordings: 1) low PO2 (less than 10 mm Hg, obtained using a specially designed hypoxic chamber) and low (6.8) pH; 2) low PO2, low pH, and high extracellular potassium ([K+]o) (10 mM); or 3) severe metabolic inhibition with cyanide (10(-6) M). Cells from each group were superfused with either the alpha-agonist phenylephrine (10(-5) or 10(-7) M, with 10(-5) M nadolol) or the beta-agonist isoproterenol (10(-6) M). Moderate changes in the action potentials were observed under conditions 1 and 2 (moderate hypoxia), whereas marked but reversible changes were observed with cyanide (severe metabolic inhibition). During moderate hypoxia in normal [K+]o, delayed afterdepolarizations or triggered activity were elicited by both alpha- (12 of 13 cells) and beta-adrenergic (five of five cells) stimulation. Increasing [K+]o during moderate hypoxia completely abolished the afterdepolarizations induced by alpha-adrenergic stimulation and prevented the occurrence of triggered activity. In contrast, the influence of beta-adrenergic stimulation was only attenuated by an increase in [K+]o. Exposure to cyanide completely prevented the induction of afterdepolarizations and triggered activity by both alpha- and beta-adrenergic stimulation. Our findings indicate that moderate hypoxia in normal [K+]o is associated with the development of adrenergic-mediated afterdepolarizations and triggered activity. In contrast, accumulation of [K+]o or severe impairment of cellular metabolism is accompanied by inhibition of adrenergic-mediated afterdepolarizations and triggered activity.
It's a long way up from comparative studies of animals to personality traits in humans
Authors: Marvin Zuckerman
Journal: Behavioral and Brain Sciences (2005)

Depue & Morrone-Strupinsky (D&M-S) have elaborated a detailed description of the motivational system for affiliation and its neurological basis. This "bottom-up" approach, based almost entirely on studies of nonhuman species, fails to connect with personality differences at the human level. A "top-down" approach looks for common biological markers in human and nonhuman species and relates these to behavior in both.
IGKV3 Proteins as Candidate “Off-the-Shelf” Vaccines for Kappa-Light Chain–Restricted B-Cell Non-Hodgkin Lymphomas
Authors: Debora Martorelli, Massimo Guidoboni, Valli De Re, Elena Muraro, Riccardo Turrini, Anna Merlo, Elisa Pasini, Laura Caggiari, Luca Romagnoli, Michele Spina, Roberta Mortarini, Daniela Gasparotto, Mario Mazzucato, Antonino Carbone, Antonio Rosato, Andrea Anichini, Riccardo Dolcetti
Journal: Clinical Cancer Research (2012)

An increasing set of B-cell non-Hodgkin lymphomas (B-NHL) show a biased usage of IGKV3-20 and IGKV3-15 immunoglobulin genes, a feature that could be exploited for the development of ready-to-use, broadly applicable cancer vaccines.The immunogenic properties of clonal IGKV3-20 and IGKV3-15 proteins were analyzed with particular focus on their ability to elicit cross-reactive responses against molecularly related IGKV proteins expressed by different B-cell lymphoproliferative disorders.IGK+ lymphoma patients show humoral and T-cell responses to IGKV3-20 and IGKV3-15 proteins and IGKV3-specific cytotoxic T lymphocytes (CTL) can be easily induced ex vivo. IGKV3-20-specific CTLs cross-react against different IGKV3 proteins, an effect mediated by the presence of 21 shared, sometimes promiscuous, T-cell epitopes, presented by common HLA class I allele products, thus assuring a broad HLA coverage of IGKV3-based vaccines. Many natural epitope variants are carried by IGK light chains expressed by a broad spectrum of B-NHLs and we show that IGKV3-20-specific CTLs cross-react also against several of these variant epitopes. Both humoral and CTL-specific responses were induced by KLH-conjugated IGKV3-20 protein in HLA-A2-transgenic mice and coinjection of IGKV3-20-specific CTLs with IGKV3-20+ or IGKV3-15+ lymphoma cells into SCID mice totally prevented tumor growth, thus confirming the ability of these effectors to mediate efficient and cross-reactive cytotoxic responses also in vivo.These results provide the rationale to exploit IGKV3 proteins as "off-the-shelf" vaccines for a large fraction of lymphoma patients.
Our Founders and Benefactors
Authors: C. E. Lakin
Journal: BMJ (1948)

In bringing our Founders and Benefactors to your notice- and it is the early benefactors I am.concerned with in particular-I do so with no little trepidation.Historical documents so rarely enshrine those traits of character, demeanour, and bearing which are so essential if a lively picture is to be presented and if the recital is to be more than a mere catalogue of benefactions and achievement.
Use of cell proliferation data in cancer risk assessment: FDA view.
Authors: R J Scheuplein
Journal: Environmental Health Perspectives (1993)

The possible uses of cell proliferation data in cancer risk assessment can be divided into three categories: direct use of mathematical models that incorporate rates of cell proliferation, use of experimental data on secondary mechanisms produced by cell proliferation, and using studies of cellular growth rates to extend the dose range of bioassay data. These three approaches are briefly discussed and some indication of their potential application to cancer risk assessment is outlined.
Assessment of the duration of action of terfenadine on histamine induced weals
Authors: L. SHALL, R. G. NEWCOMBE, R. MARKS
Journal: British Journal of Dermatology (1988)

In this study we aimed to quantify the reduction in area, perimeter and thickness of histamine induced weals 12, 18 and 24 h after a single oral dose of 120 mg terfenadine. Ten healthy volunteers were given 120 mg of terfenadine or placebo in a double-blind randomized two-period cross-over study. Twenty micrograms of histamine were then injected intradermally at 12, 18, and 24 h. The thickness of the resulting weal was measured by an A-scan pulsed ultrasound device. The area and perimeter of the resulting weal and flare were measured by tracing onto acetate sheets and using a digitizing tablet linked to a microcomputer. Just before each dose of histamine was injected, blood was taken to measure the level of the major metabolite of terfenadine. There was a significant difference between terfcnadine 120 mg and placebo in the area and perimeter of the weal and the area and perimeter of the weal and flare at 12, 18 and 24 h, but no significant difference in weal thickness. Thus, terfenadine suppresses the wealing response caused by intradermally injected histamine over a 24 h period. It may be possible, therefore, to use a once daily dose of terfenadine.
Colonization of Newborn Infants by Mycoplasmas
Authors: Jerome.O. Klein, Dorothy Buckland, Maxwell Finland
Journal: New England Journal of Medicine (1969)

Mycoplasmas were isolated from 22 per cent and 12 per cent of newborn infants with birth weights less or greater than 2.5 kg, respectively. Most isolates were identified as "T strains," and the rest as Mycoplasma hominis. Two major sites of colonization were the pharynx and the external genitalia in females. Infants positive during the first week of life remained positive, some throughout a ten-month follow-up period, but follow-up cultures in seven of 52 initially negative infants yielded mycoplasmas. Isolation of mycoplasma was associated with low birth weight: mycoplasma-positive infants had a mean weight of 2605 gm, and mycoplasma-negative neonates a mean weight of 2952 gm (p less than 0.01). Isolation of mycoplasma was also associated with prolonged rupture of fetal membranes in low-birthweight infants and with maternal fever, but not with race, maternal age or parity, or complications of earlier pregnancies, including abortions. Colonization of neonates with mycoplasmas apparently occurs during the birth process. No evidence of neonatal disease due to these agents was noted.
Respectful Treatment: A Practical Handbook of Patient Care
Authors: William Weddington
Journal: JAMA (1987)

Dr Lipp first published<i>Respectful Treatment</i>in 1977; he waited nine years before completing the second edition. The first edition was the first, and best, of several books written by psychiatrists for nonpsychiatric clinicians. The second edition draws on the strengths of the first, yet it is more than an update of a classic. The author does summarize and reference the content of consultation-liaison psychiatry for the primary care physician and medical student; moreover, he shares his point of view of patient care as an evolving clinician and maturing person. His personalized, lively style of writing captures the reader. One not only gains information and references, as with the usual stale textbook or literature review, but also reads about the change and maturation of the physician-author, now a middle-aged clinician. The admixture of content and personality makes this book charmingly different. We learn that since the first edition, the author
Abstract 4067: A T-cell factor-4 motif regulates the phenotype of hepatocellular carcinoma cells
Authors: Hironori Koga, Evan J. Walker, Orkhontuya Tsedensodnom, Jack R. Wands, Miran Kim
Journal: Cancer Research (2010)

Abstract T-cell factor (TCF) family proteins play a crucial role in regulating the activation of Wnt/β-catenin responsive target genes. Among the family proteins, TCF-4 is predominantly expressed in human HCC tissues. We have recently cloned 14 TCF-4 isoforms from human hepatoma cell lines, and naming them in alphabetical order from A to M. A TCF-4J and K pair has been identified based on the presence (K) or absence (J) of the SxxSS motif at the beginning of exon 9. This motif may modulate transcriptional activity of TCF-4 through phosphorylation/dephosphorylation of serine residues (Pukrop et al., Cancer Res 2001). However, cell-based functional analysis of this motif has yet to be performed. The AIM of this study was to investigate whether TCF-4J and K have distinct cellular phenotypes due to SxxSS motif expression. Methods: The human hepatoma cell line Huh-7 was used in this study. The cells were transfected with TCF-4J and K expression plasmids, and protein levels in cell lysates and nuclear extracts were examined by Western blot analysis. TCF-4K mutants with substitution of serine (S) to alanine (A) were generated by site-directed mutagenesis. Results: Protein expression of all cloned TCF-4 isoforms was confirmed by Western blot analysis. Expression levels of cyclin D1, which is a direct target of TCF-4, was increased in both cell lysates and the nuclear extracts of the TCF-4K, but not in TCF-4J-transfected cells. The TCF-4K isoform with a S269A mutation revealed a decrease in the expression level of cyclin D1, while the mutant with either a S272A or S273A substitution did not, which suggests that phosphorylation of serine 269 was critical to up-regulating cyclin D1 gene expression. Conclusion: The findings from functional analysis following mutagenesis of the SxxSS motif suggest that serine phosphorylation of this motif resulted in the altered target genes expression, including cyclin D1. Therefore, TCF-4 isoforms regulate the phenotype of HCC cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4067.
535. Long-Term Correction of Hyperbilirubinemia in a Rat Model of Crigler-Najjar Syndrome Type 1
Authors: Viraj P. Mane, Gabriele Toietta, Wilma Norona, Milton Finegold, Phil Ng, Arthur L. Beaudet, Anthony F. McDonagh, Brendan Lee
Journal: Molecular Therapy (2005)

Top of pageAbstract
Crigler-Najjar syndrome Type 1 is a recessively inherited disorder caused by a deficiency of the hepatic enzyme bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1), and is manifested as severe unconjugated hyperbilirubinemia. Unconjugated, water-insoluble bilirubin is not excreted and therefore accumulates in blood and in the central nervous system. This accumulation is fatal to a newborn if untreated.

Phototherapy is currently utilized, owing to the ability of blue light to break bilirubin down into water-soluble fragments. However, its efficacy is reduced upon thickening of the skin and further reduced as a patient's surfavolume ratio changes around puberty. The alternative, liver transplantation, is neither easily affordable nor widely accessible.

We have evaluated an adenoviral gene therapy modality for restoration of UGT1A1 function, over the long term, to the Gunn rat model of Crigler-Najjar Syndrome. We employed a helper-dependent adenoviral vector, whose lack of viral coding sequences allows greater persistence of transgene expression coupled to reduced chronic toxicity, as compared to early-generation adenoviral vectors. The vector contains the human UGT1A1 cDNA driven by the liver-restricted rat PEPCK promoter and a Woodchuck Posttranscriptional Regulatory Element (WPRE). Adenoviral vector was administered to Gunn rats via the tail vein at the following doses: 6, 30 and 100 (|[times]|1011 viral particles/kilogram).

Treatment did not cause significant elevation of serum transaminases which are indicative of hepatocyte injury. Furthermore, moderate thrombocytopenia developed after vector administration but had resolved within a few days of injection.

A clinically significant reduction in bilirubin levels was observed using the lowest adenoviral dose; this correction was maintained past 67 weeks. In rats receiving intermediate or high doses, complete correction of hyperbilirubinemia was sustained for over 2 years. HPLC analysis of serum processed from terminal bleeds demonstrated a dose-dependent reduction of unconjugated bilirubin, while bile HPLC analysis showed an increase in conjugated (glucuronidated) bilirubin. For an additional in vivo assay of UGT1A1 activity, HPLC analysis was carried out on bile samples taken before and after tail vein injection of bilirubin isomers BR-III and BR-XIII. Conjugation of these isomers requires UGT1A1 activity, and HPLC analysis showed an excess of bilirubin conjugating capacity in rats receiving intermediate or high doses.

Taken together, these results support the efficacy of a single systemic administration of a helper-dependent adenoviral vector towards restoring UGT1A1 enzyme function over the long term. Acute toxicities occurred but were quickly resolved. The relatively favorable dose response makes this condition a candidate for considering clinical trials in the future.
α‐Amido boronic acids: A synthetic challenge and their properties as serine protease inhibitors
Authors: Donald S. Matteson
Journal: Medicinal Research Reviews (2007)

Abstract This review includes a personal account of the history of the development of the α‐amido boronic acid synthesis and related chemistry in the author's laboratory, as well as a review of some of the more significant developments that have occurred elsewhere more recently. The simple initial target, suggested by biochemist G. E. Lienhard, proved much more elusive to reach than anticipated. 1 The circuitous effort that ultimately revealed the deceptively simple successful route, 1 for which there is still no alternative, will be described. The properties of these compounds as enzyme inhibitors will be described very briefly. More extensive reviews of the enzyme inhibiting properties of α‐amido boronic acids have appeared recently. 2 © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 233–246, 2008
Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel
Authors: Li-Min Luo, Yue Huang, Bing-Xiang Zhao, Xin Zhao, Yu Duan, Ruo Du, Ke-Fu Yu, Ping Song, Yang Zhao, Xuan Zhang, Qiang Zhang
Journal: Biomaterials (2012)
Altered Peritoneal Permeability in Patients with Systemic Vasculitis
Authors: KARL D. NOLPH
Journal: Annals of Internal Medicine (1971)

Decreased peritoneal membrane permeability should impair the transperitoneal diffusion of larger molecular weight solutes more than that of smaller solutes during peritoneal dialysis. To see if systemic vascular disease produces such selective functional alterations in man, peritoneal clearances of urea (Curea), creatinine (Ccr) and urate (Curate) were measured in four patients with severe systemic vascular disease. Mean values for Curea, Ccr/Curea, and Curate/Curea in the study patients were significantly (P < 0.01) below values for these functions in the control group. The selective reductions in the clearances of higher molecular weight solutes suggest alterations of functional permeability of the peritoneal capillaries or mesothelium, or both, in patients with systemic vascular disease.
THE ESTROGENIC SUBSTANCES
Authors: EDWARD A. DOISY
Journal: JAMA (1941)

Although several investigators<sup>1</sup>contributed to the early development of research on estrogens, rapid progress did not begin until after the publication of the vaginal smear reaction<sup>2</sup>for the detection of these substances. The work was given additional impetus by the discovery of the high concentration of estrogens in the urine of pregnant women and in the urine of pregnant mares.<sup>3</sup>These discoveries, which provided excellent sources of the estrogens and the means of quantitative determination, were of paramount importance to the isolation of the estrogens and the determination of their structure, as well as to the introduction of an ample supply of estrogenic substances for therapeutic use. The subsequent availability of pure estrogens has permitted an investigation of their role in sex physiology, particularly with respect to the estrous and the menstrual cycle, and of their interrelationships with other internal secretions. <h3>CHEMISTRY OF ESTROGENIC SUBSTANCES</h3> At this
A History of Medicine, vol 1: Primitive and Ancient Medicine
Authors: Robert Rietz
Journal: JAMA (1992)

Unlike many books about the history of medicine, this one is written by a physician-researcher (MD-PhD) who developed an interest in history. The book is the proposed first volume in a series of seven and covers primitive and ancient medicine. The foreword makes for interesting reading and provides the basis for why the book was written. Physicians, at least, will especially like this part. Another essential component is chapter 1, "Primitive and Naturalistic Medicine." It lays out information about magical and practical treatments that has been deduced from paleopathology and current practices by primitive peoples. Since all societies are presumed to have gone through a period of superstition-magic as applied to disease, this chapter is required as a foundation for the others. Prioreschi has seven more chapters that cover different geographical areas and cultures but not Greek or Roman medicine, which will presumably appear in future volumes. The other chapters