tbuckley/cabot-search huggingface dataset:
Circulating calcium modulates adrenaline induced cyclic adenosine monophosphate production
Authors: R. C PRIELIPP, T. HILL, D. WASHBURN, G. P ZALOGA
Journal: Cardiovascular Research (1989)

Inotropic support of the failing myocardium may combine calcium with adrenaline in an attempt to augment the haemodynamic actions of each drug. We have previously shown, however, that calcium blunts adrenaline induced increases in blood pressure and cardiac output in animals and man. The mechanisms by which calcium may interfere with the haemodynamic actions of adrenaline are not well understood. Adrenaline is known to stimulate adenylate cyclase and increase levels of cellular cyclic adenosine monophosphate (cAMP), a crucial second messenger in cell regulation. We evaluated the effect of increased circulating calcium levels on adrenaline stimulated cAMP production in laboratory animals. Calcium infusion in rats nearly doubled the circulating ionised calcium concentration, from 1.27 (SEM 0.03) mM to 2.3(0.18) mM. Adrenaline infusion significantly increased plasma cAMP in saline infused control animals, from 26(6) pmol.ml-1 to 98(22) pmol.ml-1, whereas there was no increase in cAMP plasma levels in the calcium infused rats. The apparent inhibition of adenylate cyclase by calcium may participate in a negative feedback system which helps protect cells from harmful intracellular calcium overload.
Bile Ascites in Adults
Authors: CONRAD E. NAGLE, DARLENE FINK-BENNETT, JOHN E. FREITAS
Journal: Clinical Nuclear Medicine (1985)

Hepatobiliary scintigraphy has been recognized as a useful diagnostic tool in detecting the presence and site of bile leaks. The authors report a case of bile ascites secondary to a postsurgical biliary leak, the scintigraphic findings in bile ascites, and the potential use of paracentesis, in combination with hepatobiliary scintigraphy, in confirming the presence of bile ascites and a bile leak.
Haemophilus influenzae Type B Resistant to Ampicillin
Authors: Waheed Khan
Journal: JAMA (1974)

Recently, two infants with severe infections due to ampicillin-resistant strains of<i>Haemophilus influenzae</i>type B were treated at Children's Hospital National Medical Center. In both cases, it was necessary to change therapy to chloramphenicol. One patient with meningitis died while the second with bacteremia and pneumonia recovered. A survey of 60 recent isolates of<i>H influenzae</i>type B in the Washington community showed that 10% were ampicillin-resistant. The enzyme produced by these resistant strains was found to be a β-Iactamase. Careful appraisal is now necessary to decide whether ampicillin is the drug of choice as initial therapy in<i>H influenzae</i>meningitis in pediatric patients. (<i>JAMA</i>229:298-301, 1974)
ENCEPHALOID CANCER OF THE LUNGS SIMULATING LARYNGEAL PHTHISIS
Authors: J. Cockle
Journal: BMJ (1854)

TuE history of Cancer of the Lungs still remains so avow- edly imperfect, that each individual observation carefully recorded must possess a value by contributing to fill up the existing deficiency.The subjoined case presents many points of interest:- Mr., aged 64 years, of middle stature and nervous temperament, an accountant by profession, had enjoyed an average share of good health to within a period of two years preceding his decease.His habits were temperate and regular; and he was capable of attending to his pro- fessional duties until within a few weeks of his death.The only important commemorative is, that he had lost a brother a short time before from well-marked encephaloid disease.In the middle of the year 1853, Mlfr.-suffered from the follicular affcction of the throat long known to French pathologists, and of late brought into a somewhat undue prominence by Dr. Horace Green.The uvula was hypertrophous; the tonsils large; and the mucous follicles of the fauces were largely developed.His cough was frequent, distressing, and laryngeal in character.There were no ab- normal sounds over e1t'ier the larynx or trachea.The ex- pectoration, usually mucous and frothy, was at times copious and muco-purulent.The voice was hoarse, and the breath- ing slightly stridulous (from above).Occasionally, though by no means constantly, sonorous rile was audible, sometimes over one lung, sometimes over the other.Air appeared to July 13th.The rash was well out.July 16th.The pulse was weak.There was restless.ness, and occasional delirium; the rash was vivid.Am. monia and brandy were ordered, with beef-tea.
Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia
Authors: Akira Tomonari, Naoki Shirafuji, Tohru Iseki, Jun Ooi, Hitomi Nagayama, Atsuko Masunaga, Arinobu Tojo, Kenzaburo Tani, Shigetaka Asano
Journal: American Journal of Hematology (2002)

Abstract Pulmonary alveolar proteinosis (PAP) is a heterogeneous disease that occasionally develops with hematological malignancy. However, PAP in association with hematopoietic stem cell transplantation is quite rare. Here we present the first report of a patient who developed PAP after cord blood transplantation (CBT). A 45‐year‐old female with AML underwent unrelated CBT. On day +2 after CBT she developed congestive heart failure with diffuse alveolar infiltrates in the bilateral lungs. Despite treatment, the alveolar infiltrates further increased with progression of multiple organ failure (MOF). She died from MOF before hematopoietic recovery on day +27. Post‐mortem study revealed that massive amorphous materials positive for periodic acid‐Schiff stain filled in the pulmonary alveoli. These findings led to a diagnosis of PAP. The bone marrow was hypocellular without the leukemic cells. The impaired immunity during the period of leukopenia as well as the impaired clearance of surfactant proteins might contribute to the development of PAP. Am. J. Hematol. 70:154–157, 2002.© 2002 Wiley‐Liss, Inc.
Chronic interstitial lung disease due to Epstein-Barr virus infection in two infants
Authors: A Pfleger, E Eber, H Popper, M.s Zach
Journal: European Respiratory Journal (2000)

This case study reports on two infants, 5 and 6 months of age, respectively, with chronic interstitial lung disease who presented with failure to thrive, tachypnoea, rales and mild hypoxaemia. Epstein-Barr virus (EBV) was detected by in situ hybridization in lung biopsy specimens and by EBV-deoxyribonucleic acid-polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) fluid in one patient and by in situ hybridization and PCR analysis in BAL fluid in the second patient. There was serological evidence of immunoglobulin G antibodies to EBV capsid antigen by indirect immunofluorescence in both patients. After 7 months of respiratory symptoms one patient was successfully treated with a 10 day course of intravenous ganciclovir followed by oral acyclovir for 20 days. The other patient became symptom free after 3.5 months of respiratory symptoms, without any specific antiviral medication. During a follow-up of 2 and 1.5 yrs, respectively, both infants remained symptom free and showed normal physical development.
High Discrepancy of Driver Mutations in Patients with NSCLC and Synchronous Multiple Lung Ground-Glass Nodules
Authors: Chunyan Wu, Chao Zhao, Yang Yang, Yayi He, Likun Hou, Xuefei Li, Guanghui Gao, Jingyun Shi, Shengxiang Ren, Haiqing Chu, Caicun Zhou, Jun Zhang, Gerald Schmid-Bindert
Journal: Journal of Thoracic Oncology (2015)
Reply: A unified classification system for eukaryotic transposable elements should reflect their phylogeny
Authors: Thomas Wicker, François Sabot, Aurélie Hua-Van, Jeffrey L. Bennetzen, Pierre Capy, Boulos Chalhoub, Andrew Flavell, Philippe Leroy, Michele Morgante, Olivier Panaud, Etienne Paux, Phillip SanMiguel, Alan H. Schulman
Journal: Nature Reviews Genetics (2009)
Panel Predicts Shortfall in Care for the Aged
Authors: Mike Mitka
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Neutral Zone
Authors: Jason D. Eubanks
Journal: Annals of Internal Medicine (2013)

Ad Libitum16 April 2013The Neutral ZoneJason D. Eubanks, MDJason D. Eubanks, MDFrom University Hospitals Case Medical Center, Cleveland, Ohio.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-8-201304160-00012 Audio Reading - “The Neutral Zone” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Neutral Zone," by Jason D. Eubanks. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A roofer ... Author, Article, and Disclosure InformationAffiliations: From University Hospitals Case Medical Center, Cleveland, Ohio.Current Author Address: Jason D. Eubanks, MD; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “The Neutral Zone” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Neutral Zone," by Jason D. Eubanks. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 16 April 2013Volume 158, Issue 8Page: 634KeywordsBoneHeartKneesPainStormsWarts ePublished: 16 April 2013 Issue Published: 16 April 2013 CopyrightCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Role of ankle taping and bracing in the athlete.
Authors: M J Callaghan
Journal: British Journal of Sports Medicine (1997)

Adhesive tape is often used to help athletes recover from ligament sprains of the ankle or to prevent further injury. The choice of taping technique or material is often decided by personal preference, superstition, or anecdote. More recently, the use of ankle braces has become more prevalent, but reasons for their use are similarly variable. As ankle sprains are a major cause of an athlete's disability and time off sport, the choice of the method of support should be more scientifically reasoned. This paper attempts to review the literature concerning the effects of various methods of ankle support on swelling, stability, range of movement, proprioception, muscle function, gait, and performance tests. There is still some contradiction in the literature about the effects of taping and braces in both the acute and chronic phases of ligament sprains of the ankle.
Abstract 2952: The PKC-iota inhibitor ICA-1 combined with TRAIL for glioblastoma therapy.
Authors: Andrea N. McCray, Shraddha Desai, Mildred Acevedo-Duncan
Journal: Cancer Research (2013)

Abstract Glioblastoma multiforme is a very aggressive brain tumor. Temozolimide is the standard clinical therapy following surgery which offers a limited survival advantage. The low survival rates of glioblastoma patients require further investigation into pre-clinical combination therapy options with apoptosis abilities. One such chemotherapeutic approach is the use of the novel PKC-iota inhibitor, ICA-1, combined with rhTRAIL. T98G or U87 glioblastoma cells were treated with ICA-1 for 48h or 72h, respectively, with or without rhTRAIL in a 24-well format. Based on flow cytometric analysis, the overall apoptosis rate for the T98G cells exposed to ICA-1 plus TRAIL was the most significant with no distinction between early and late apoptosis rates. In addition, the immunofluorescence analysis showed higher T98G cell death for the combination therapy. Further flow cytometric analysis showed that ICA-1 plus TRAIL generated significantly more late apoptosis for U87 cells than any other treatment. The mechanism of action for this combinatorial therapy is currently under investigation. However, our in vitro data demonstrated that ICA-1 plus TRAIL induced 60-70% apoptosis in U87 glioblastoma cells and T98G glioblastoma cells which may offer a better survival advantage in pre-clinical animal models. Citation Format: Andrea N. McCray, Shraddha Desai, Mildred Acevedo-Duncan. The PKC-iota inhibitor ICA-1 combined with TRAIL for glioblastoma therapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2952. doi:10.1158/1538-7445.AM2013-2952
Lipoprotein-proteoglycan complexes induce continued cholesteryl ester accumulation in foam cells from rabbit atherosclerotic lesions.
Authors: P Vijayagopal, S R Srinivasan, J H Xu, E R Dalferes, B Radhakrishnamurthy, G S Berenson
Journal: Journal of Clinical Investigation (1993)

We studied the metabolism of lipoprotein-proteoglycan complexes by macrophage-derived foam cells. Foam cells were isolated from atherosclerotic rabbit aortas. ApoB-lipoprotein-proteoglycan complex was isolated from human aorta fibrous plaque lesions and LDL-proteoglycan complex was formed in vitro. Both in vitro and in vivo complexes stimulated cholesteryl ester synthesis in foam cells by a dose-dependent, saturable process that resulted in the intracellular accumulation of cholesteryl ester. Stimulation of cholesteryl ester synthesis was linear with time over a 32-h period. Polyinosinic acid inhibited the stimulation of cholesteryl ester synthesis by the complexes by 32-37%, whereas cytochalasin D only produced a 6-16% inhibition. Foam cells degraded 125I-LDL-proteoglycan complex and 125I-acetyl LDL in a saturable, dose-dependent manner. Excess unlabeled acetyl-LDL inhibited the degradation of 125I-LDL-proteoglycan complex by 52%, while LDL had no effect. Similarly, excess unlabeled complex suppressed the degradation of 125I-acetyl-LDL by 48%. Foam cells degraded 125I-methyl-LDL-proteoglycan complex to the same extent as 125I-LDL-proteoglycan complex. These results show that foam cells from atherosclerotic lesions metabolize lipoprotein-proteoglycan complexes predominantly via receptor-mediated endocytosis and consequently continue to accumulate intracellular cholesteryl ester.
PENINSULA DEL CORONADO.
Authors: WALTER LINDLEY
Journal: JAMA (1896)

In Los Angeles, as elsewhere, the physician and his family must take their summer vacation. In fact it may be more necessary here, as there is but little change in the seasons, while in New York there are the four regular seasons, each decidedly different from the other. Sometimes we go to the mountains from ten to fifty miles away, sometimes to Catalina Island twenty-five miles from the mainland, but this year we decided to take our outing on the Peninsula of Coronado, which juts out from the mainland in front of San Diego, 126 miles south of Los Angeles. This trip can be taken by sea or rail, the latter being usually chosen. The Santa Fé Railroad in traversing this distance takes a delightful route, first through the orchards and orange groves (never say orange orchards) of Los Angeles and Orange Counties for fifty miles and then at the
Use of Cardiovascular Procedures among Black Persons and White Persons: A 7-Year Nationwide Study in Patients with Renal Disease
Authors: Gail L. Daumit, Judith A. Hermann, Josef Coresh, Neil R. Powe
Journal: Annals of Internal Medicine (1999)

Black persons historically undergo fewer invasive cardiovascular procedures than white persons.To determine whether acquisition of Medicare health insurance and comprehensive care for severe illness reduce ethnic disparity in use of cardiovascular procedures.7-year longitudinal analyses in a cohort from the United States Renal Data System.Health care institutions in the United States.Nationwide random sample of 4987 adult black and white patients with incident end-stage renal disease (ESRD) from 303 dialysis facilities in 1986 to 1987.Medical history and service use records, physical examination, and laboratory data. Main outcome measures were receipt of a coronary catheterization or revascularization procedure before (baseline) and after (follow-up) development of ESRD and acquisition of Medicare, adjusted for clinical and socioeconomic variables.At baseline, 9.9% of white patients and 2.8% of black patients had had a cardiac procedure; the odds were almost three times greater in white than in black patients (adjusted odds ratio, 2.92 [95% CI, 2.04 to 4.18]). During follow-up, white patients were only 1.4 times more likely than black patients to have a procedure (adjusted relative risk, 1.41 [CI, 1.13 to 1.77]); rates were 7.8% for white persons and 8.5% for black persons. In patients with Medicare coverage before development of ESRD, the initial three-fold difference in procedure use was eliminated over follow-up (odds ratio, 1.05 [CI, 0.56 to 1.60]). For procedures after hospital admission for myocardial infarction or coronary disease, no difference between ethnic groups was seen during follow-up (relative risk, 1.12 [CI, 0.68 to 1.85]).Differences between ethnic groups in use of cardiovascular procedures narrowed markedly once a serious illness (ESRD) developed and adequate insurance coverage was ensured; the disparity was eliminated in patients with previous Medicare insurance or a stronger indication for a procedure. These findings suggest that almost equal access to care is attainable by combining insurance with delivery of comprehensive, clinically appropriate care.
Improvement of cast nephropathy with plasma exchange depends on the diagnosis and on reduction of serum free light chains
Authors: N. Leung, M.A. Gertz, S.R. Zeldenrust, S.V. Rajkumar, A. Dispenzieri, F.C. Fervenza, S. Kumar, M.Q. Lacy, J.A. Lust, P.R. Greipp, T.E. Witzig, S.R. Hayman, S.J. Russell, R.A. Kyle, J.L. Winters
Journal: Kidney International (2008)
In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)
Authors: A.A. Deschamps, A.A. van Apeldoorn, H. Hayen, J.D. de Bruijn, U. Karst, D.W. Grijpma, J. Feijen
Journal: Biomaterials (2003)
Considerations for Discussion — 1956
Authors: George W. Waterman
Journal: New England Journal of Medicine (1957)

'T'O have served as president of the New England surgical Society for the past year has, indeed, been a high honor. I am thankful for your confidence in so choosing me and can only hope that my conduct of the duties of president has been acceptable and has merited your trust.The year has been a pleasant and stimulating one, weighed down only by the necessity of fulfilling my obligations in the writing of a presidential address. I have chosen, therefore, to consider several subjects that are currently open for discussion, which have, to be sure, interested me in the . . .
Doctors and homosexuality
Authors: A. J Smith
Journal: BMJ (1994)

Homophobia is the wrong word

Editor,--Lynn Rose finds that doctors' attitudes depend on their core values, which in turn are determined by their cultural and social background.1 While she correctly criticises the inclusion of homosexuality in psychiatric classifications in the past, she uses a term that I find puzzling in both its application and its meaning--namely, homophobia. …
Study of 100 patients injured by London underground trains 1981-6.
Authors: R A Cocks
Journal: BMJ (1987)

One hundred patients who were injured by London underground trains during 1981-6 were studied; 43 of them died. Deliberate self harm was probable in roughly three quarters. Alcohol intoxication was thought to play an important part in a further tenth of cases. Thirteen were psychiatric inpatients at the time of the incident, and a further two had recently been discharged. Early warning of a potential suicide attempt was given during the 24 hours preceding the incident in 15 of the cases. Some of the deaths in the psychiatric patients may have been preventable.
Sclerosant injection for varicose veins.
Authors: P G Martin, H H Eastcott
Journal: BMJ (1971)

the fact that they are hospital-based in decid- ing which arrangement is the better.But I am certain of one thing: that there is need for experiment and that in this most important work policy based purely on depart- mental decree is not good enough.If, in the broadest sense, we are to get value for money this airing of the resettlement of the disabled should be followed by a planned comparative study.-I am, etc.,
Intracoronary Thrombus and Platelet Glycoprotein IIb/IIIa Receptor Blockade With Tirofiban in Unstable Angina or Non–Q-Wave Myocardial Infarction
Authors: Xue-Qiao Zhao, Pierre Théroux, Steven M. Snapinn, Frederic L. Sax
Journal: Circulation (1999)

The present study describes the effects of tirofiban, a nonpeptide platelet glycoprotein (GP) IIb/IIIa receptor blocker, on the characteristics of culprit lesions in patients with unstable angina (UA) or non-Q-wave myocardial infarction (NQWMI).Of 1915 patients enrolled in PRISM-PLUS, 1491 had a readable film obtained a median of 65 hours after randomization. A core laboratory examined the culprit lesions for intracoronary thrombus burden (primary end point) and for TIMI flow grade distribution and severity of the obstruction and of underlying coronary artery disease (secondary end points). The combination of tirofiban plus heparin compared with heparin alone significantly reduced the intracoronary thrombus burden of the culprit lesions (OR=0.77, P=0.022), improved the perfusion grade (OR=0.65, P=0.002), and decreased the severity of the obstruction (P=0.037), but it did not influence the severity of the underlying plaque. Persistence of a thrombus in 45% of patients was associated with a 2.4-fold increase in the odds of death at 30 days (P=0.005) and a 2-fold increase in the odds of myocardial infarction (P=0.002).The addition of tirofiban to heparin reduced the thrombus burden of the culprit lesion and improved distal perfusion in patients with UA or NQWMI, which supports the clinical benefit observed with the combination treatment.
VOLUME OVERLOAD AT DISCHARGE MEASURED USING BIOELECTRICAL IMPEDANCE VECTOR ANALYSIS PREDICTS OUTCOME IN PATIENTS HOSPITALIZED WITH ACUTE DECOMPENSATED HEART FAILURE
Authors: Bryan Dieffenbach, Carolyn Haunschild, Benjamin Kipper, Navaid Iqbal, Yang Xue, Alan Maisel
Journal: Journal of the American College of Cardiology (2012)