tbuckley/cabot-search huggingface dataset:
Thrombotic Thrombocytopenic Purpura-like Syndrome Associated With Infective Endocarditis
Authors: Arnold S. Bayer
Journal: JAMA (1977)

A thrombotic thrombocytopenic purpura (TTP)-like syndrome was the chief presenting feature in two patients with infective endocarditis. Clinical and laboratory aberrations of the syndrome were rapidly reversed by specific antimicrobial therapy. Hypocomplementemia and high levels of circulating immune complexes were detected initially in both patients. Because these returned to normal as the TTP syndrome abated, an immunopathologic mechanism may have been operative.
Uptake and biodistribution of 99mtechnetium methylene-[32P]diphosphonate during endosteal healing around titanium, stainless steel and hydroxyapatite implants in rat tibial bone
Authors: Jona Sela, Jashovam Shani, David Kohavi, Wilfred Aubrey Soskolne, katzir Itzhak, Barbara D. Boyan, Zvi Schwartz
Journal: Biomaterials (1995)
500. Tetanus Toxin Heavy Chain-Streptoavidin Fusion Protein for Targeted Motor Neuron Gene Delivery through Metabolically Biotinylated AAV
Authors: Qingshan Teng, JeffreyS. Bartlett, Thais Federici, Jun Yang, NicholasM. Boulis
Journal: Molecular Therapy (2006)

Background: Adeno-associated viral vector (AAV) mediates long- term and safe gene expression in a variety of tissue types in vitro and in vivo. AAV vector has a wide rang of tissue tropism. However when tissue-specific gene expression is preferred, strategies such as genetic modification of the viral capsid or the inclusion of a tissues-specific promoter in the expression cassette are usually employed. We report here the development of a versatile AAV targeting system to achieve enhanced and specific motor neuron gene delivery.
Doctor who worked during suspension is allowed to return to practice
Authors: C. Dyer
Journal: BMJ (2010)

The former head of the multiple sclerosis research clinic at Guy’s Hospital in London, who was suspended for 12 months by the General Medical Council for research fraud, has been allowed to return to practice.

Consultant neurologist Mohammad Sharief was guilty of misconduct for working during the first three weeks of his suspension, but the misconduct was not serious enough to impair his fitness to practise, a GMC panel held.

He was suspended in April 2008 for dishonesty in including patients in clinical trials who failed to fit the inclusion criteria and in asking a …
A COMPARATIVE STUDY OF ETHMOIDAL AND SPHENOIDAL OPERATIONS
Authors: J. J. SHEA
Journal: JAMA (1922)

The appreciation that the posterior ethmoidal cells and the sphenoidal sinus are the causative factors in many of the optical nerve disorders has centered attention on this region. Formerly, the anterior ethmoidal cells held the center of the stage in our attention because of their relationship to the frontal sinus. The older operations were so designed that the anterior cells were first attacked and were more thoroughly exenterated at the expense of an uncertainty of thoroughness in the posterior region. If the sphenoidal sinus and the posterior ethmoidal cells are the important factors, then the successful operation must be based on thoroughness in their exenteration. In like manner, the curet, guided by the sense of touch, must give way to the trustworthy biting forceps, controlled by the sense of sight. The fundamental law of safe ethmoidal and sphenoidal surgery is to work by sight only, avoiding tearing by accomplishing each
Tests in Patients With Pacemakers
Authors: Joseph B. Rogoff
Journal: JAMA (1977)

To the Editor. —  In answer to a reader's query (237:1736, 1977) concerning the safety of electrical stimulation in neurological tests, Mr Veale of the Food and Drug Administration states, Scrupulous attention should also be paid to grounding, if the stimulator is ac powered and has a grounded output , especially if monitoring equipment is used or the patient is grounded in some way [my italics].  The fact is that one of the conditions for successful nerve conduction velocity studies is to have an ungrounded stimulator output. If Mr Veale's directions were followed and the stimulator output were to be grounded, no measurement of nerve conduction would be possible because of an overriding artifact. The patient, on the other hand, must always be grounded to eliminate this artifact with a ground-free stimulator.  I agree with Mr Veale's conclusions in all other aspects.
TP53 mutations in myeloid malignancies are either homozygous or hemizygous due to copy number-neutral loss of heterozygosity or deletion of 17p
Authors: M Jasek, L P Gondek, N Bejanyan, R Tiu, J Huh, K S Theil, C O'Keefe, M A McDevitt, J P Maciejewski
Journal: Leukemia (2009)
Occupational Asthma in Greenhouse Flower and Ornamental Plant Growers
Authors: Eduard Monsó, Ramón Magarolas, Isabel Badorrey, Katja Radon, Dennis Nowak, Josep Morera
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

The objective of this study was to determine the prevalence of occupational asthma and sensitization to workplace allergens in greenhouse flower and/or ornamental plant growers. A random sample of 40 growers who cultivated such crops and had participated in the European Farmers' Study was selected for a cross-sectional study that included (1) greenhouse characteristics and air contaminants (dust, endotoxin, and microorganisms), (2) respiratory symptoms, (3) occupational asthma diagnosed by bronchial provocation challenge, and (4) sensitization to workplace flowers or molds. Associations among respiratory symptoms, sensitization, greenhouse characteristics, and air contaminants were analyzed by logistic regression modeling. Thirty-nine growers agreed to participate (response rate, 97.5%). Bronchial provocation challenge confirmed occupational asthma in three workers (7.7%), all of them sensitized to workplace flowers or molds. No cases of occupational asthma were found among nonsensitized growers. Poor ventilation proved to be a marginal risk factor for wheezing (air velocity: odds ratio, 0.11; 95% confidence interval, 0.01-1.04). Sensitization to flowers or molds was found in 13 of 38 growers (34.2%) but was not related to greenhouse characteristics. We conclude that one-fourth of greenhouse flower and/or ornamental plant growers sensitized to workplace flowers or molds have occupational asthma, a disease that is suffered by 8% of the growers who cultivate these crops.
IL-7 Promotes T <sub>H</sub> 1 Development and Serum IL-7 Predicts Clinical Response to Interferon-β in Multiple Sclerosis
Authors: Li-Fen Lee, Robert Axtell, Guang Huan Tu, Kathryn Logronio, Jeanette Dilley, Jessica Yu, Mathias Rickert, Bora Han, Winston Evering, Michael G. Walker, Jing Shi, Brigit A. de Jong, Joep Killestein, Chris H. Polman, Lawrence Steinman, John C. Lin
Journal: Science Translational Medicine (2011)

High serum IL-7 predicts responsiveness of multiple sclerosis patients to IFN-β therapy and indicates a T H 1 cell–driven disease.
Radiation Exposure Patterns Aboard the<i>USS Nautilus</i>
Authors: John H. Ebersole
Journal: New England Journal of Medicine (1957)

THE increasing interest in the application of nuclear reactors to civilian industry indicates that radiation safety principles will in the future become a matter of widespread interest to the medical profession. Curiosity and possible public apprehension will require that all physicians have some basic knowledge of the field. More specifically, the increase in the percentage of the population exposed routinely to ionizing radiation may lead to confusing diagnostic and therapeutic situations. As more and more emphasis is placed on controlling lifetime exposure to ionizing radiation, radiologists, in particular, must be aware of the exposure patterns experienced by personnel employed in . . .
THE PHYSIOLOGY OF BLOOD-VESSELS IN PSORIASIS
Authors: W. G. C. PATERSON
Journal: British Journal of Dermatology (1932)

Journal Article THE PHYSIOLOGY OF BLOOD‐VESSELS IN PSORIASIS Get access W. G. C. PATERSON, M.D.(N.Z.), M.R.C.P.Lond W. G. C. PATERSON, M.D.(N.Z.), M.R.C.P.Lond Late Junior Medical Registrar, St. John's Hospital for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 44, Issue 6, 1 June 1932, Pages 310–315, https://doi.org/10.1111/j.1365-2133.1932.tb09610.x Published: 01 June 1932
Experimental myasthenia gravis. A murine system.
Authors: P W Berman, J Patrick
Journal: The Journal of Experimental Medicine (1980)

Mice from eight inbred strains were immunized with acetylcholine receptor (AChR) purified from Torpedo californica. All mice developed high concentrations of serum antibodies (10(-6) M) against the immunogen and approximately 80% possessed antibodies reactive with mouse nicotinic AChR. 33% of the mice immunized (n = 236) developed muscular weakness and flaccid paralysis. Behavioral, electrophysiological, and pharmacological similarities were found between the experimentally induced muscular weakness and the disease myasthenia gravis. Susceptibility to experimental myasthenia was found to be strain dependent in that the frequency of paralysis was much greater in some strains than others. The occurrence of muscular weakness and flaccid paralysis did not correlate with the concentration of antibodies reactive with T. californica or mouse AChR. Anti-receptor antibodies which increased the rate of AChR degradation on the mouse muscle cell line, BC3H-1, were found in the serum of both myasthenic and nonmyasthenic mice. 40% of the mice tested possessed antibodies reactive with antigenic determinants present on mouse receptor but not T. californica receptor. The occurrence of antibodies unique to mouse receptor did not correlate with myasthenia. Thus, myasthenia in the mouse does not occur simply as a consequence of the presence of antibodies directed against cell surface antigenic determinants of AChR. If anti-AChR antibodies are both necessary and sufficient for the induction of myasthenia, then these studies suggest that populations of a particular structure and/or specificity are required. It is anticipated that the mouse model of myasthenia gravis will permit the regulation of the anti-receptor immune response to be studied in detail.
Sequential Loss of Splenic and Then Hepatic Function in a Patient with Thorotrast Loading
Authors: MOHAMED A. ANTAR, HASSANALI KASSAMALI, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1989)

ANTAR, MOHAMED A. M.D., PhD.; KASSAMALI, HASSANALI M.D.; SPENCER, RICHARD P. M.D., PhD. Author Information
Joint Commission will collect, publicize outcomes
Authors: A. A. Skolnick
Journal: JAMA (1993)

STARTING in 1994 after almost a century of stumbling efforts to measure the quality of health care, the US health care industry appears ready to begin measuring provider performance and to make this information available to the public. In May, the board of commissioners of the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), Oakbrook Terrace, Ill, approved a number of policies that will radically change the way that organization surveys and accredits hospitals and other health care organizations. Beginning in January 1994, the joint commission will establish an "indicator monitoring system," which will include a national database for comparing a set of "performance measures" that are designed to rate individual health care providers based on patient outcome. In addition, the commission plans to make many of its findings public, ending a confidentiality policy that critics say protects bad providers. "By making the indicator system operational, the joint commission will
Effects of GP IIb/IIIa Receptor Monoclonal Antibody (7E3), Heparin, and Aspirin in an Ex Vivo Canine Arteriovenous Shunt Model of Stent Thrombosis
Authors: Raj R. Makkar, Frank Litvack, Neal L. Eigler, Masato Nakamura, Pamela A. Ivey, James S. Forrester, Prediman K. Shah, Robert E. Jordan, Sanjay Kaul
Journal: Circulation (1997)

Background Thrombosis is an important limitation of metallic coronary stents, especially in smaller vessels in which shear rates are high. Monoclonal antibody to platelet glycoprotein IIb/IIIa receptor (7E3) has been shown to inhibit shear-induced platelet aggregation. In this study, we compared the effects of 7E3, heparin, and aspirin on stent thrombosis in an ex vivo arteriovenous shunt model of high-shear blood flow. Methods and Results An ex vivo arteriovenous shunt was created in 10 anesthetized dogs. Control rough-surface slotted-tube nitinol stents (n=72) expanded to 2 mm in diameter in a tubular perfusion chamber were interposed in the shunt and exposed to flowing arterial blood at a shear rate of 2100 s −1 for 20 minutes. The animals were treated with intravenous murine 7E3 (Fab′) 2 (0.2, 0.4, and 0.8 mg/kg), heparin (100 U/kg), or aspirin (10 mg/kg). Effects of the test agents on thrombus weight, platelet aggregation, platelet P-selectin expression, bleeding time, and activated clotting time (ACT) were quantified. 7E3 reduced stent thrombosis by 95% (20±1 to 1±1 mg, P &lt;.001) and platelet aggregation by 94% (14±2 to 1±1 Ω, P &lt;.001) at the highest dose (0.8 mg/kg). 7E3 significantly prolonged bleeding time but had no effect on ACT and platelet P-selectin expression. Heparin prolonged ACT but had no significant effect on stent thrombosis or platelet aggregation. Aspirin, although it inhibited platelet aggregation by 65%, had no effect on stent thrombosis (19±2 versus 20±1 mg in controls). Conclusions 7E3 produced a dose-dependent inhibition of acute stent thrombosis under high-shear flow conditions. Stent thrombosis was resistant to heparin and aspirin. Thus, 7E3 may be an effective agent for preventing stent thrombosis.
New analysis fuels debate on merits of prescribing statins to low risk people
Authors: Z. Kmietowicz
Journal: BMJ (2014)

The controversy concerning the prescribing of statins to a wider section of the population showed no signs of abating this week after a new analysis—this time of high quality observational studies involving data on millions of patients—found that the risk of harmful effects from statins was very small and similar to those seen in clinical trials.1

The finding is fuelling the debate on whether statins should be extended to healthy people who are at low risk of cardiovascular disease, as recommended in draft guidance from the National Institute for Health and Care Excellence (NICE).2

The latest research comes just two weeks after the publication of a meta-analysis of 29 randomised controlled trials that found that serious adverse events occurred just as often in patients taking a placebo (14.9% of patients in primary prevention trials and 11.2% of those in secondary prevention trials) as they did in patients taking statins (14.6% for primary and 9.9% for secondary prevention).3

That the two recent analyses concur gives leverage to people who say that statins should be more widely used to prevent cardiovascular disease because the risks associated with taking them are very small.

Arguments about how far statins should be used in preventing cardiovascular disease intensified at the weekend when …
Early Diagnosis of Cervical Spinal Cord Meningioma
Authors: Lewis H. Rosenbaum
Journal: JAMA (1983)

TUMORS of the foramen magnum and the upper part of the cervical spinal cord are often initially seen with confusing clinical syndromes that are frequently ascribed to a conversion hysteria or fibromyositis. In a major review of such tumors, Dodge et al<sup>1</sup>stated, "Unless the physician obtains an accurate history and attributes sufficient significance to the patient's often bizarre and at times seemingly functional complaints, he is likely to deny the patient his ultimate opportunity for cure." Despite this warning, it seems that scant attention has been given to the role of the patient's history in the early diagnosis of such tumors, and diagnostic studies are only undertaken when signs of spinal cord compression are apparent. The following case report describes a patient in whom the history of recumbent neck pain and electromyographic abnormalities suggested the diagnosis of a meningioma in the upper part of the cervical spinal cord
THE EFFECT OF A GROWTH-RETARDING FACTOR FROM NORMAL TISSUES ON SPONTANEOUS CANCER OF MICE
Authors: James B. Murphy, Ernest Sturm
Journal: The Journal of Experimental Medicine (1934)

Extracts of desiccated homologous embryo skin and placenta decrease markedly the rate of postoperative local recurrence after the surgical removal of spontaneous cancer of mice. Autografts after a short period of contact with these extracts either failed to grow, or, in the majority of instances, their subsequent growth was definitely retarded. Intraperitoneal injection of the extracts was followed by cessation of growth of established tumors in more than two-thirds of the animals treated, and among these many of the tumors regressed and over 20 per cent were completely absorbed. Tumor mice treated with either extract rarely developed new malignant foci, though this happened frequently in untreated mice.
A Haven for High-Risk Research Opens
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wasted women doctors.
Authors: P Richards
Journal: BMJ (1978)

suitable use of the talents of women doctors is an economic necessity, said Mrs Castle in one of her rare constructive moments as Secretary of State for Social Services; she might have mentioned that personal fulfilment is of consequence too, but that perhaps is neither an economic nor a political necessity. What she also did not say (and may not have known) is that effective harnessing of this increasing national resource is a distant prospect. To marry the career aspirations of women doctors with their domestic responsibilities has proved both too difficult and too expensive for Britain; a few tentative steps have been taken in the right direction, but they fall far short of the need. Doctors are expected to have a capacity for critical thought, reasoned judgment, and pragmatic action, tools that quickly reduce to ashes the current arrangements for the part-time post graduate training of married women in hospital specialties. Indeed, the whole structure would be laughable if its implica tions were not so serious. The failure of the system is most obvious to postgraduate clinical tutors, who, being primarily occupied with larger responsibilities to clinical or laboratory work, teaching, and research, have little energy left to wrestle with the imperfections of the structure of postgraduate medical education. Yet those whose critical edge has not yet been blunted by the sheer inertia of the system should either speak out for change or stand down. In the event, however, the National Association of Clinical Tutors at their recent annual London meeting eyed women only to the extent of an excellent, enter taining, but in the circumstances irrelevant, talk on the history of women in medicine. Surely it is women's future, not their past, which should concern us ?
DRUG-INDUCED TOXIC EPIDERMAL NECROLYSIS
Authors: Madalene C.Y. Heng
Journal: British Journal of Dermatology (1985)

Journal Article DRUG‐INDUCED TOXIC EPIDERMAL NECROLYSIS Get access Madalene C.Y. Heng Madalene C.Y. Heng Division of Dermatology, Department of Medicine U.C.L.A.‐San Fernando Valley, Internal Medicine Program, Veterans Administration Medical Center, 16111, Plummer Street, Supulveda, CA 91343, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue 5, 1 November 1985, Pages 597–600, https://doi.org/10.1111/j.1365-2133.1985.tb02384.x Published: 01 November 1985
Medically unnecessary denials: Where the standards come from and how physicians can participate. From the Office of the General Counsel
Authors: E. Hirshfeld
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal