tbuckley/cabot-search huggingface dataset:
PREDICTION OF ATRIAL FIBRILLATION RECURRENCE AT SIX MONTHS POST DIRECT CURRENT CARDIOVERSION: RIGHT ATRIAL VOLUME, LEFT ATRIAL VOLUME OR BOTH?
Authors: Christina Luong, Kenneth Gin, Matthew Bennett, John Jue, Krishnan Ramanathan, Marion Barnes, Pamela Colley, Darby Thompson, Teresa S.M. Tsang
Journal: Journal of the American College of Cardiology (2013)
Abstract 2849: Pharmacodynamic biomarkers of anti-PD-L1 activity in pre-clinical mouse tumor models.
Authors: Marigold Boe, Mahrukh Huseni, Brittany Jiang, Hartmut Koeppen, Heather Maecker, Bryan Irving, Priti Hegde, Marcin Kowanetz
Journal: Cancer Research (2013)

Abstract Programmed cell death 1 ligand 1 (PD-L1, CD274, B7-H1) is an immune checkpoint molecule expressed in various tissues, including multiple peripheral blood mononuclear cells and placenta. PD-L1 binds its receptor PD-1 on activated T cells to negatively regulate their function in both physiological and pathological conditions. PD-L1 also binds B7.1 (CD80), further down modulating immune responses. Importantly, numerous cancers resist T-cell mediated cytotoxic activity by over-expressing PD-L1. The goal of this study was to identify pharmacodynamic biomarkers of response to agents blocking PD-L1/PD-1 pathway in pre-clinical models. CT-26 and MC-38 murine mouse tumor models were selected for this analysis, based on their PD-L1 expression and in-vivo sensitivity to anti-PD-L1 treatment. Tumors have been collected at various time points following treatment with an antibody blocking PD-L1 binding to PD-1 and B7.1. Subsequently, FACS, IHC, qPCR and a multiplex qPCR-based expression assay measuring a panel of ∼90 immune-related biomarkers have been used to evaluate changes in major immune cell subtypes and their activation status. We show that the intra-tumoral immune environment undergoes a time-sensitive dynamic modulation in response to PD-L1 pathway blockade, including an early and potent Th1 driven CTL response, as measured by relevant markers. Additionally, our findings show that targeting PD-L1 in pre-clinical tumor models can reinvigorate the host immune responses against the tumor and lead to T-cell mediated tumor killing. Our data also support identification of potential pharmacodynamic biomarkers that can be used to monitor activity of agents targeting the PD-L1 pathway in the clinic. Citation Format: Marigold Boe, Mahrukh Huseni, Brittany Jiang, Hartmut Koeppen, Heather Maecker, Bryan Irving, Priti Hegde, Marcin Kowanetz. Pharmacodynamic biomarkers of anti-PD-L1 activity in pre-clinical mouse tumor models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2849. doi:10.1158/1538-7445.AM2013-2849
A case of loin pain: a cause close to the heart
Authors: T. J. Cahill, K. Nagaratnam, R. Browning, S. Anthony, J. Dwight
Journal: BMJ (2012)

A 44 year old man with type 2 diabetes presented with sudden onset severe pain in the left loin, which was associated with several episodes of vomiting. Although he reported exertional chest discomfort in the preceding year, he had not experienced chest pain or breathlessness in the weeks leading up to the admission. On examination, he was normotensive, with a heart rate of 80 beats/min and an oxygen saturation of 98% on air. He was tender in the left renal angle, but the rest of his clinical examination was unremarkable. Electrocardiography showed deep anterior T wave inversion. Laboratory tests showed a raised white cell count (13.9×109/L; reference range 4-11), C reactive protein (65.1 mg/L; <10mg/L; 1 mg/L=9.52 nmol/L), and troponin I (0.29 µg/L; <0.05). Renal and liver function tests were within normal limits. A clinical diagnosis was confirmed by imaging, shown below (fig 1⇓).





### 1 What type of imaging was used and what were the findings?

#### Short answer

This is an arterial phase contrast enhanced computed tomogram of the abdomen. Contrast is absent beyond the proximal segment of the left renal artery, with non-enhancement of the left kidney. A wedge shaped area of non-enhancement is also seen in the right kidney, consistent with a renal infarct. The findings are consistent with bilateral …
The Clinical Investigation of a Codeine Resin Complex
Authors: Leo J. Cass, Willem S. Frederik
Journal: New England Journal of Medicine (1958)

THROUGHOUT the history of medicine, opium and its derivatives have been relied upon as proved pain suppressants. And, even today, codeine remains one of the most effective analgesics for oral administration despite the current use of several new synthetic substitutes in medical practice. It has been reported that some of the new synthetic analgesics do not cause addiction or habituation. The long-term effect of these new agents, particularly when they are used in high dosage over a long period, has not been completely assessed.An ultimate goal in the present search for an improved analgesic is the development of a . . .
Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis
Authors: Aijun Qiao, Jichao Liang, Yaojun Ke, Chenghong Li, Ying Cui, Lian Shen, Huabing Zhang, Anfang Cui, Xiaojun Liu, Changzheng Liu, Yong Chen, Yi Zhu, Youfei Guan, Fude Fang, Yongsheng Chang
Journal: Hepatology (2011)

Human patatin-like phospholipase domain-containing 3 ( PNPLA 3) is associated with increased liver fat content and liver injury. Here, we show that nutritional status regulates PNPLA3 gene expression in the mouse liver. Sterol response element binding protein-1 (SREBP-1) activated PNPLA3 gene transcription via sterol regulatory elements (SREs) mapped to the promoter region. Chromatin immunoprecipitation and electrophoretic mobility shift assays confirmed that SREBP-1 proteins bound to the identified SREs. Furthermore, SREBP-1c mediated the insulin and liver X receptor agonist TO901317-dependent induction of PNPLA3 gene expression in hepatocytes. Adenovirus-mediated overexpression of mouse PNPLA3 increased intracellular triglyceride content in primary hepatocytes, and knockdown of PNPLA3 suppressed the ability of SREBP-1c to stimulate lipid accumulation in hepatocytes. Finally, the overexpression of PNPLA3 in mouse liver increased the serum triglyceride level and impaired glucose tolerance; in contrast, the knockdown of PNPLA3 in db/db mouse liver improved glucose tolerance. Conclusion: Our data suggest that mouse PNPLA3 , which is a lipogenic gene directly targeted by SREBP-1 , promotes lipogenesis in primary hepatocytes and influences systemic lipid and glucose metabolism. (Hepatology 2011;)
The Angiogenic Factor Secretoneurin Induces Coronary Angiogenesis in a Model of Myocardial Infarction by Stimulation of Vascular Endothelial Growth Factor Signaling in Endothelial Cells
Authors: Karin Albrecht-Schgoer, Wilfried Schgoer, Johannes Holfeld, Markus Theurl, Dominik Wiedemann, Christina Steger, Rajesh Gupta, Severin Semsroth, Reiner Fischer-Colbrie, Arno G.E. Beer, Ursula Stanzl, Eva Huber, Sol Misener, Daniel Dejaco, Raj Kishore, Otmar Pachinger, Michael Grimm, Nikolaos Bonaros, Rudolf Kirchmair
Journal: Circulation (2012)

Background— Secretoneurin is a neuropeptide located in nerve fibers along blood vessels, is upregulated by hypoxia, and induces angiogenesis. We tested the hypothesis that secretoneurin gene therapy exerts beneficial effects in a rat model of myocardial infarction and evaluated the mechanism of action on coronary endothelial cells. Methods and Results— In vivo secretoneurin improved left ventricular function, inhibited remodeling, and reduced scar formation. In the infarct border zone, secretoneurin induced coronary angiogenesis, as shown by increased density of capillaries and arteries. In vitro secretoneurin induced capillary tubes, stimulated proliferation, inhibited apoptosis, and activated Akt and extracellular signal-regulated kinase in coronary endothelial cells. Effects were abrogated by a vascular endothelial growth factor (VEGF) antibody, and secretoneurin stimulated VEGF receptors in these cells. Secretoneurin furthermore increased binding of VEGF to endothelial cells, and binding was blocked by heparinase, indicating that secretoneurin stimulates binding of VEGF to heparan sulfate proteoglycan binding sites. Additionally, secretoneurin increased binding of VEGF to its coreceptor neuropilin-1. In endothelial cells, secretoneurin also stimulated fibroblast growth factor receptor-3 and insulin-like growth factor-1 receptor, and in coronary vascular smooth muscle cells, we observed stimulation of VEGF receptor-1 and fibroblast growth factor receptor-3. Exposure of cardiac myocytes to hypoxia and ischemic heart after myocardial infarction revealed increased secretoneurin messenger RNA and protein. Conclusions— Our data show that secretoneurin acts as an endogenous stimulator of VEGF signaling in coronary endothelial cells by enhancing binding of VEGF to low-affinity binding sites and neuropilin-1 and stimulates further growth factor receptors like fibroblast growth factor receptor-3. Our in vivo findings indicate that secretoneurin may be a promising therapeutic tool in ischemic heart disease.
Latex allergen elimination in natural latex sap and latex gloves by treatment with alkaline potassium hydroxide solution
Authors: X. Baur, J. Rennert, Z. Chen
Journal: Allergy (1997)

Antigenic proteins in latex products can cause type I allergy. We investigated the effects of potassium hydroxide (KOH) solution on the allergenicity of proteins in natural latex sap and latex gloves by using an EAST competitive inhibition immunoassay and skin prick test. Latex sap was mixed with KOH solution at different concentrations and incubated over various periods of time at room temperature. Latex gloves were washed in KOH solution for different times at 30 degrees C and 90 degrees C. Our immunoassay results for the subsequently extracted latex proteins demonstrated a KOH concentration-, temperature-, and time-dependent decrease in allergenicity, finally resulting in complete loss of IgE-binding activity. In the skin prick test, we found only four weakly positive reactions to proteins extracted from KOH-washed gloves in 30 latex-sensitized patients. In addition, up to 97% of the aqueous extractable protein content could be removed from latex gloves by washing in KOH solution under certain conditions. These results suggest that antigenic proteins in natural latex sap and latex gloves can be changed by treatment with KOH solution, which is followed by a loss of their capability to bind specific IgE antibodies from most latex-sensitized patients.
Secondary Photocrosslinking of Injectable Shear‐Thinning Dock‐and‐Lock Hydrogels
Authors: Hoang D. Lu, Danielle E. Soranno, Christopher B. Rodell, Iris L. Kim, Jason A. Burdick
Journal: Advanced Healthcare Materials (2013)

Abstract Shear‐thinning hydrogels are useful in numerous applications, including as injectable carriers that act as scaffolds to support cell and drug therapies. Here, we describe the engineering of a self‐assembling Dock‐and‐Lock (DnL) system that forms injectable shear‐thinning hydrogels using molecular recognition interactions that also possess photo‐triggerable secondary crosslinks. These DnL hydrogels are fabricated from peptide‐modified hyaluronic acid (HA) and polypeptide precursors, can self‐heal immediately after shear induced flow, are cytocompatible, and can be stabilized through light‐initiated radical polymerization of methacrylate functional groups to tune gel mechanics and erosion kinetics. Secondary crosslinked hydrogels retain self‐adhesive properties and exhibit cooperative physical and chemical crosslinks with moduli as high as ∼10 times larger than moduli of gels based on physical crosslinking alone. The extent of reaction and change in properties are dependent on whether the methacrylate is incorporated either at the terminus of the peptide or directly to the HA backbone. Additionally, the gel erosion can be monitored through an incorporated fluorophore and physical–chemical gels remain intact in solution over months, whereas physical gels that are not covalently crosslinked erode completely within days. Mesenchymal stem cells exhibit increased viability when cultured in physical– chemical gels, compared with those cultured in gels based on physical crosslinks alone. The physical properties of these DnL gels may be additionally tuned by adjusting component compositions, which allows DnL gels with a wide range of physical properties to be constructed for use.
Vascular access calcification predicts mortality in hemodialysis patients
Authors: Georg Schlieper, Thilo Krüger, Zivka Djuric, Tatjana Damjanovic, Natasa Markovic, Leon J. Schurgers, Vincent M. Brandenburg, Ralf Westenfeld, Sinisa Dimkovic, Markus Ketteler, Diana C. Grootendorst, Friedo W. Dekker, Jürgen Floege, Nada Dimkovic
Journal: Kidney International (2008)
Doxorubicin Plus Sorafenib in Treatment of Advanced Hepatocellular Carcinoma—Reply
Authors: Ghassan Abou-Alfa
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Patent Infarct-Related Artery Is Associated With Reduced Long-term Mortality After Percutaneous Transluminal Coronary Angioplasty for Postinfarction Ischemia and an Ejection Fraction &lt;50%
Authors: Francine K. Welty, Murray A. Mittleman, Stanley M. Lewis, Wendy L. Kowalker, Robert W. Healy, Samuel J. Shubrooks, James E. Muller
Journal: Circulation (1996)

Prognosis after myocardial infarction (MI) is influenced by the presence of post-MI ischemia and possibly the patency of the infarct-related artery. The purpose of this study was to compare long-term outcome (reinfarction and death) in patients with open versus closed coronary arteries after percutaneous transluminal coronary angioplasty performed for MI complicated by persistent ischemia.Between 1981 and 1989, 505 patients underwent percutaneous transluminal coronary angioplasty for post-MI ischemia at the Deaconess Hospital. Long-term incidence (mean follow-up, 34 months) of death, nonfatal reinfarction, repeated coronary angioplasty, and coronary bypass surgery was determined for 479 patients and then compared on the basis of the status of the artery, open versus closed, at the end of angioplasty. The 5-year Kaplan-Meier actuarial mortality rate was 4.9% for 456 patients with open infarct-related arteries and 19.4% for 23 patients with closed infarct-related arteries (P=.0008). Multivariate Cox proportional hazards analyses controlling for age, sex, number of diseased vessels, type and location of MI, and year of coronary angioplasty revealed a hazard ratio for death for closed compared with open arteries of 6.1 (95% CI, 1.8 to 20.0). Among patients with ejection fractions <50%, a closed artery was associated with a higher mortality (p=.0014) compared with patients with open arteries. The status of the artery was not associated with a difference in mortality in patients with ejection fractions > or = 50%.As open artery after coronary angioplasty for post-MI ischemia is associated with significantly lower long-term mortality, particularly in patients with ejection fractions <50%.
Bone Destruction and Regeneration in a Patient with Breast Cancer
Authors: Ashok Malani, Rony M Abou-Jawde
Journal: New England Journal of Medicine (2008)

A 58-year-old woman presented with a cavitating left breast lesion and increasing pain in the left arm. For over a year she had noticed an enlarging breast mass but did not seek medical advice. Imaging showed metastatic disease in the chest and brain. Serum calcium and alkaline phosphatase levels were within the normal range. Since she had a marked decrease in function of her left arm, a plain radiograph was obtained. The image disclosed a destructive process involving the proximal humerus, with multiple pathologic fractures, presumably due to bony metastatic disease (Panel A). Palliative left total mastectomy was performed. The . . .
The Office Practice of Internists
Authors: Allen C. Johnson
Journal: JAMA (1965)

This paper reports on some aspects of a study which was developed in cooperation with the New York State Society of Internal Medicine. This organization was interested in the development of methodology for evaluating the quality of medical care being rendered by its members in their own offices. As a preliminary to the methodological study itself, information on the background and characteristics of the practice of the members of the society was obtained by means of a questionnaire mailed to each member. At the time of the study, the society had 960 members, of whom 505 returned a completed questionnaire to the study group. The nature of the society and the methodology of this study were outlined in the first paper of this series.<sup>1</sup> The questionnaire completed by the internist was designed, in part, to elicit a description of his new patients and of patients who were under his
Rare Medical Occurrences in Jewish Traditions
Authors: Philip Lanzkowsky
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Recently, three fascinating patients had unusual complications resulting from Jewish religious practices. Jewish religion has developed a set of practices and mores aimed at protecting health. We describe three syndromes that resulted from the observance of Jewish law and tradition. <h3>Shofar-Blowing-Induced Interstitial Emphysema.—</h3> According to the Bible, the Shofar, an animal's horn prepared for use as a musical instrument, is sounded on Rosh Hashanah and certain other times. Rosh Hashanah is designated as<i>yom teruah</i>("a day of blowing") (Numbers 29:1). Together with the reed, the Shofar is one of the earliest musical instruments known to man that is still in use. A 17 year-old boy was admitted to Long Island Jewish-Hillside Medical Center with notable pain in the midline of the neck anteriorly and difficulty swallowing after his blowing of the Shofar. A roentgenogram of the chest and neck showed interstitial emphysema in the mediastinum and
Psychological Medicine: An Introduction to Psychiatry
Authors: Donald E. Widmann
Journal: JAMA (1964)

The authors of any introductory text bear a difficult burden, for they must compress a large body of theory and an even larger mass of clinical data into brief and readable form. This task is especially difficult when the subject is psychiatric illness, for which no single, well-formulated, and uniformly accepted theoretical basis exists. The authors of this text have chosen to present brief discussions of the history of psychiatry, mental symptoms, etiology of mental illness, and legal psychiatry, and more lengthy clinical descriptions and therapeutic recommendations. They offer little discussion of normal personality development and make little use of information from the biological and social sciences. The descriptions of the organic brain syndromes and the psychoses are brief and well done. The neuroses are less clearly presented, partly because the authors have difficulty in unifying dynamically and organically determined factors. Occasional statements are open to question, eg, "parents can
Effect of Postoperative Adjuvant Chemotherapy with Tegafur-Uracil on Survival in Patients with Stage IA Non-small Cell Lung Cancer: An Exploratory Analysis from a Meta-Analysis of Six Randomized Controlled Trials
Authors: Chikuma Hamada, Masahiro Tsuboi, Mitsuo Ohta, Shigefumi Fujimura, Ken Kodama, Munehisa Imaizumi, Hiromi Wada
Journal: Journal of Thoracic Oncology (2009)
What I Remember Most (For S'ne, 12)
Authors: Sarah Leeper
Journal: Annals of Internal Medicine (2010)

Ad Libitum5 January 2010What I Remember Most (For S'ne, 12)Sarah LeeperSarah LeeperFrom Brown University, Providence, RI 02906.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-1-201001050-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What I remember most is the sweateryou wore, shivering in my August arms.Lighter than laundry, quiet as paperwhile pain was unfolding in you.What I remember most is the wastinginto a skeleton in your family's closet.Naked joists, headers, girders:All burnt churches imitate you.What I remember most is the chest x-ray,empty space and points of light.I say: TB. I think: Andromeda—Constellations exploding through you.What I remember most is your dark curveagainst white sheets, warm commabetween corpses. You sleep,you rehearse. I breathe for you.We have luck. Luck, obscene ... Author, Article, and Disclosure InformationAffiliations: From Brown University, Providence, RI 02906.Current Author Address: Sarah Leeper, Brown University, 41 Jenckes Street, Apartment 4, Providence, RI 02906. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 January 2010Volume 152, Issue 1Page: 68KeywordsSkeletonSleepThorax ePublished: 5 January 2010 Issue Published: 5 January 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clofibrate and Coronary Arteries
Authors: A.E. Dorr
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The Krasno and Kidera study (<b>219</b>:845,1972) is an important contribution to medical knowledge. At this time it does appear that clofibrate offers protection against new coronary events. However, the conclusion that protection is not related to lipid lowering is not warranted from the data presented. Apparently, the authors reached this conclusion from the fact that patients with hyperlipidemia who failed to attain a reduction of lipids while taking clofibrate did not experience myocardial infarction. The authors state that the lipid reduction of clofibrate responders was related to initial lipid levels and that treated and untreated men with normal initial lipid levels did not develop myocardial infarction. It would appear, then, that nonresponders to clofibrate might have had lower initial lipid levels than responders and, therefore, were not subject to the same risk. There is also the problem of statistical significance between nonresponders and responders or between