Cushing's Syndrome and the Changing Times
Authors: ROBERT G. DLUHY
Journal: Annals of Internal Medicine (1982)

Editorials1 July 1982Cushing's Syndrome and the Changing TimesROBERT G. DLUHY, M.D., GORDON H. WILLIAMS, M.D.ROBERT G. DLUHY, M.D.Search for more papers by this author, GORDON H. WILLIAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-1-131 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough Cushing's syndrome represents a group of diseases, the hypercortisolism can be viewed more simply as a consequence of a primary adrenal neoplasm or of continuous adrenocorticotropic hormone (ACTH) stimulation leading to bilateral adrenal hyperplasia. The ACTH hypersecretion may be marked, as in neoplasms that secrete ACTH "ectopically" (primarily lung neoplasms). On the other hand, pituitary ACTH secretion may be modestly increased or "inappropriately" normal in the setting of elevated Cortisol levels, suggesting an abnormality in the negative feedback relation between Cortisol and ACTH in these patients (so-called idiopathic hyperplasia or Cushing's disease). That there may be abnormal regulation of...References1. LIDDLE G. Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab. 1960;20:1539-60. CrossrefMedlineGoogle Scholar2. TYRRELLBROOKSFITZGERALD JRP. Cushing's disease: selective trans-sphenoidal resection of pituitary microadenomas. N Engl J Med. 1978;298:753-8. CrossrefMedlineGoogle Scholar3. LANKFORDTUCKER H STBLACKARD HGW. A cyproheptadine-reversible defect in ACTH control persisting after removal of the pituitary tumor in Cushing's disease. N Engl J Med. 1981 ;305:1244-8. CrossrefMedlineGoogle Scholar4. CRAPO L. Cushing's syndrome: a review of diagnostic tests. Metabolism. 1979;28:955-77. CrossrefMedlineGoogle Scholar5. SAWINBRAYIDELSON CGB. Overnight suppression test with dexamethasone in Cushing's syndrome. J Clin Endocrinol Metab. 1968;28:422-4. CrossrefMedlineGoogle Scholar6. ASHCRAFTVAN HERLEVENERGEFFNER MASD. Serum Cortisol levels in Cushing's syndrome after low- and high-dose dexamethasone suppression. Ann Intern Med. 1982;97:21-6. LinkGoogle Scholar7. REESBESSERJEFFCOATEGOLDIEMARKS LGWDV. Alcohol-induced pseudo-Cushing's syndrome. Lancet. 1977;1:726-8. CrossrefMedlineGoogle Scholar8. GOLD E. The Cushing syndromes: changing views of diagnosis and treatment. Ann Intern Med. 1979;90:829-44. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Endocrine-Hypertension Unit Brigham and Women's Hospital Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCushing's syndrome due to ectopic proopiomelanocortin gene expression by islet cell carcinoma of the pancreasCaesarean section in a patient with Cushing’s syndromeThe Adrenal Cortex and Hypertension 1 July 1982Volume 97, Issue 1Page: 131-133KeywordsAdrenocorticotropic hormoneCortisolLung and intrathoracic tumors Issue Published: 1 July 1982 PDF downloadLoading ...