tbuckley/cabot-search huggingface dataset:
Recent Advances in the Endocrinology of Puberty
Authors: S. R. OJEDA, W. W. ANDREWS, J. P. ADVIS, S. SMITH WHITE
Journal: Endocrine Reviews (1980)

The term puberty is derived from the Latin pubes, hair. In trying to define puberty, scientists of the 18th century gave more emphasis to the changes in phenotypical appearance associated with puberty than to the morphological and functional changes undergone within the gonads at this time. Researchers of the earlier part of the present century were already more concerned in their definitions with the acquisition of reproductive capacity resulting from the completion of gonadal and accessory sex organ development. Thus, in 1929 Parkes defined puberty as "the phase in which the individual acquires sexual maturity" (from Ref. 1). According to him puberty (in the female) consists of two phases: the gradual prepubertal development of the accessory organs and the abrupt appearance of the first estrus and ovulation. Years later Asdell defined puberty as "the time at which reproduction first becomes possible, i.e. when germ cells are released" (from Ref. 1). Almost 20 years later (1965), Donovan and van der Werff ten Bosch defined puberty as "the phase of bodily development during which the gonads secrete hormones in amounts sufficient to cause accelerated growth of the genital organs and the appearance of secondary sexual characters" (1).
INTER-RATER RELIABILITY OF THE 2009 APPROPRIATE USE CRITERIA FOR CARDIAC RADIONUCLIDE IMAGING
Authors: Siqin Ye, Leroy Rabbani, Christopher Kelly, Maureen R. Kelly, Matthew Lewis, Yehuda Paz, Clara Peck, Shaline Rao, Shepard Weiner, Andrew Einstein
Journal: Journal of the American College of Cardiology (2013)
Features of airway remodeling in different types of <scp>C</scp>hinese chronic rhinosinusitis are associated with inflammation patterns
Authors: L‐L. Shi, P. Xiong, L. Zhang, P‐P. Cao, B. Liao, X. Lu, Y‐H. Cui, Z. Liu
Journal: Allergy (2012)

Abstract Background The remodeling patterns in different types of chronic rhinosinusitis ( CRS ) have rarely been compared, particularly the difference between eosinophilic and noneosinophilic CRS with nasal polyps ( CRS w NP ). Moreover, whether there is a link between remodeling and inflammation remains controversial. Objective To directly compare the remodeling features of different CRS and to explore their relationship with inflammation in C hinese patients. Methods Histologic characteristics of surgical samples were analyzed in 33 controls, 72 eosinophilic and 76 noneosinophilic CRS w NP , and 72 CRS without nasal polyps ( CRS s NP ) patients. Tissue samples from 38 controls, 26 eosinophilic and 26 noneosinophilic CRS w NP , and 32 CRS s NP patients were measured for mRNA and/or protein expression of profibrotic growth factors, metalloproteinases ( MMP s), tissue inhibitor of metalloproteinases ( TIMP s), hypoxia‐inducible factor ( HIF )‐1α, interleukin ( IL )‐8, eosinophil cationic protein ( ECP ), and myeloperoxidase ( MPO ). Results The amount of collagen decreased, whereas the edema scores increased, from CRS s NP to noneosinophilic CRS w NP and to eosinophilic CRS w NP . Transforming growth factor ( TGF )‐β2 protein levels were enhanced in CRS s NP compared with CRS w NP . TIMP ‐4 protein levels decreased in eosinophilic CRS w NP compared with noneosinophilic CRS w NP and CRS s NP . The number of neutrophils decreased from CRS s NP to noneosinophilic CRS w NP and to eosinophilic CRS w NP . ECP levels were only up‐regulated in eosinophilic CRS w NP . ECP levels and neutrophil number correlated positively with the severity of edema and fibrosis, respectively. Neutrophils were the major sources of TGF ‐β2 in CRS s NP and noneosinophilic CRS w NP . Conclusion Distinct remodeling patterns are revealed for different types of CRS , particularly for eosinophilic and noneosinophilic CRS w NP . Tissue remodeling associates with inflammation in CRS .
Public-health impact of outdoor and traffic-related air pollution: a European assessment
Authors: N Künzli, R Kaiser, S Medina, M Studnicka, O Chanel, P Filliger, M Herry, F Horak, V Puybonnieux-Texier, P Quénel, J Schneider, R Seethaler, J-C Vergnaud, H Sommer
Journal: The Lancet (2000)
Repetitive usage testing with budesonide in experimental nickel-allergic contact dermatitis in individuals hypersensitive to budesonide
Authors: M. Isaksson, M. Bruze
Journal: British Journal of Dermatology (2001)

Journal Article Repetitive usage testing with budesonide in experimental nickel–allergic contact dermatitis in individuals hypersensitive to budesonide Get access M. Isaksson, M. Isaksson Department of Occupational and Environmental Dermatology, Malmö University Hospital, SE‐205 02 Malmö, Sweden Search for other works by this author on: Oxford Academic Google Scholar M. Bruze M. Bruze Department of Occupational and Environmental Dermatology, Malmö University Hospital, SE‐205 02 Malmö, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 1, 1 July 2001, Pages 38–44, https://doi.org/10.1046/j.1365-2133.2001.04279.x Published: 01 July 2001
GPs to follow up patients after surgery
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

Responsibility for carrying out routine check-ups of patients six weeks after surgery is to shift from consultants to GPs. The Department of Health estimates that the move will save the NHS in England £1.9bn (€2.8bn; $3.7bn) a year. 

The proposal, which will cover elective surgery, has been recommended by David Colin-Thome, the national clinical director for primary care, in a report that is due to be published later this month. The health department is almost certain to adopt the plan, because it will free up surgeons' …
Abrege de Rhumatologie
Authors: J. T. Scott
Journal: Annals of the Rheumatic Diseases (1978)

the author accepts as a syndrome with high titre of antibodies to ribonucleoprotein and a favourable prognosis.The final chapter deals with immune complex disease and the complement system, followed by an appendix covering immu- nological tests in the rheumatic diseases.The book is well written, clearly set out, very readable, and covers a large field with commendable brevity.
Abstract 3332: An artificial zinc finger glycosylase causes site-directed DNA damages and specifically kills the targeted cancer cells via synthetic lethality.
Authors: Hua Fung, Stanton L. Gerson, Carlos F. Barbas
Journal: Cancer Research (2013)

Abstract Synthetic lethality is a new developed therapy, in which PARP inhibitor selectively kills BRCA-deficient cancer cells. However, BRCA-deficiency only accounts for a small fraction of cancers. We are interesting in applying synthetic lethal approach to target all cancers regardless BRCA statute. As single strand break (SSB) is the start point of the synthetic lethal, we hypothesized the targeted induction of persistent SSB at tumor unique sequences (cancer somatic mutation sequences) with assistance of synthetic lethality would specifically kill cancer cells. To test this principle we have constructed a six-zinc finger/mutant uracil glycosylase fusion protein (zinc finger glycosylase, ZFG). Upon binding to a specific 18-bp sequence by ZFG six-zinc binding domain, the mutated uracil glycosylase will remove a cytosine residue leaving an apyrimidinic site, which is subsequently convert to SSB by AP-endonuclease cleavage. The SSB lesion is capable of being repaired, however, upon repair, the zinc finger binding site is restored and the site-specific ZFG will again initiate a lesion leading to a persistent SSB. We have transfected ZFGs into BRCA2-deficient human breast cancer MCF7 and lung cancer A549 cells, the cells were then treated with PARP inhibitors. We observed increased killing of the ZFG-transfected cells compare to mock-transfected controls. Since BRCA2 deficiency causes homologous recombination (HR) repair defect, we next sought to determine if inhibitors of HR is a suitable substitute for loss of BRCA2. We are testing this concept by transfection of ZFG to BRCA2-proficient MCF7 cells with the treatment of combination of PARP and HR inhibitors, to determine whether 1. Combination of PARP and HR inhibitors treatments can achieve synthetic lethality; 2. ZFG constructs can enhance synthetic lethality. We conclude ZFG coupled with synthetic lethality is a promising direction towards the development of cancer specifically treatment. Citation Format: Hua Fung, Stanton L. Gerson, Carlos F. Barbas. An artificial zinc finger glycosylase causes site-directed DNA damages and specifically kills the targeted cancer cells via synthetic lethality. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3332. doi:10.1158/1538-7445.AM2013-3332
Effect of Inhaled Interleukin-5 on Airway Hyperreactivity and Eosinophilia in Asthmatics
Authors: HUAN-ZHONG SHI, CHANG-QING XIAO, DING ZHONG, SHOU-MING QIN, YI LIU, GUO-RONG LIANG, HUI XU, YI-QIANG CHEN, XUE-MING LONG, ZHENG-FU XIE
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

In order to investigate the role of interleukin-5 (IL-5) in airway hyperreactivity and eosinophilia, we observed the effect of inhaled recombinant human IL-5 on airway responsiveness to methacholine and cell populations in induced sputum in eight patients with allergic bronchial asthma using a placebo-controlled study design. Our results demonstrated that the inhalation of IL-5 did not alter lung function in allergic asthmatics. In the control experiments receiving either vehicle or 0.4 ng of endotoxin, methacholine PC20 values did not change nor did the numbers of eosinophils or eosinophil cationic protein (ECP) sputum values change from baseline. In contrast, after IL-5 inhalation, methacholine PC20 fell from baseline (0.90 ± 166 mg/ml) to 0.32 ± 1.63 mg/ml (p < 0.01) at 24 h, and to 0.55 ± 1.49 mg/ml (p < 0.05) at 48 h. Accompanying this increased airway sensitivity was a significant eosinophilia and elevated concentrations of ECP in induced sputum. Our data provided direct evidence that IL-5 increases airway responsiveness and infiltration of activated eosinophils into the airway in patients with allergic bronchial asthma. It also could be concluded that the observed airway hyperreactivity and eosinophilia were not endotoxin related.
934. Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Apolipoprotein(a) Kringles
Authors: Kyuhyun Lee, Seong-Tae Yun, Hong-Kyu Lee, Eui-Cheol Jo
Journal: Molecular Therapy (2006)

Top of pageAbstract
We previously demonstrated the anti-angiogenic activities of apolipoprotein (a) (apo (a)) kringles LK68 and LK8 in vitro and in vivo. Gene transfer of these kringles mediated by adeno-associated viral vectors (AAV) further elucidated a potential anti-metastatic and anti-tumor activity of LK68 and LK8 in vivo. In the present study, we further evaluated the therapeutic potential of gene therapy with recombinant AAV carrying LK68 gene (rAAV-LK68) in the treatment of colon cancer. Intramuscular administration of rAAV- LK68 (1 |[times]| 109 infectious units/mouse) appeared to extend the latent period of the tumors and reduced the rate of tumor growth, compared to the negative control groups. rAAV-produced LK68 inhibited tumor growth by more than 65% (P<0.0069 versus each negative control group) in immuno-deficient mice bearing subcutaneously transplanted human colon tumor cells. Furthermore, rAAV-LK68 administration reduced by 85% (P<0.0094 versus each negative control group) the number of tumor nodules metastasized to the liver, when evaluated in a murine hepatic metastasis model. Histological and immunohistochemical analyses of the tumor sections showed that rAAV-produced LK68 inhibited tumor angiogenesis by more than 60% (P<0.01 versus negative control group) and triggered threefold more tumor apoptosis, compared to the negative control. Therefore, anti-angiogenecity induced by rAAV-LK68 administration was presumed to trigger suppression of tumor growth and metastasis. These results collectively suggest that rAAV-LK68 is a potent agent to inhibit tumor growth and hepatic metastasis of human colon cancer.
UK government to spend £105m to improve stroke services
Authors: Robert Short
Journal: BMJ (2007)

An initiative from the World Health Organization has been launched to make drugs as simply and safely available to children as they are to adults.Speaking last week at the launch in London, WHO's assistant director general, Howard Zucker, said that "there is a gap between the availability of children's medicines and the actual need.That gap is global and must be addressed."The problem is not new."It's a reality we've lived with for many years," Dr Zucker admitted.Most drugs are developed for and tested in adults.Less than a third come in a form appropriate for children.As a result, many children are treated using drugs that are effectively unlicensed.Medical staff may be obliged to estimate the appropriate fraction of an adult dose, and then crush tablets or extract part of the contents of a capsule.One study by WHO has shown that drug errors are three times as common in children as in adults (JAMA 2001;285:2114-20).Unicef claims that of the 10 million under 5s who will have died by the end of this year, specific products for children could have saved two thirds.Hans Hogerzeil, WHO's director of drugs policy and standards, listed areas in which more effort is needed, in which drugs do exist but were of unknown safety and efficacy.Examples include agents for dealing with tuberculosis; HIV; and several neglected conditions, such as schistosomiasis.Development is essential in areas in which adult drugs need to be adapted to make them suitable and safe for children.Illnesses in this category include malaria, neonatal infections that could be treated by antibiotics, and tuberculosis.Finally, said Dr Hogerzeil, improved access is the priority where drugs exist but are prevented from reaching the children who needed them because of cost."Make medicines child size" is at www.who.int/childmedicines/en. WHO launches� campaign to make drugs� s�afer for childrenUK NEWS GMC approves change in the standard of proof, p 1230 World NEWS �d�� �a�� a��o�� dr�g co�panies to pro�ote off��a�e� �ses, p 122� �d�� �a�� a��o�� dr�g co�panies to pro�ote off��a�e� �ses, p 122� , p 122� ��j.co�Go�iath �oves into hea�thcare records Go�iath �oves into hea�thcare records
845-4 Noninvasive assessment of in-stent restenosis by 16-slice multislice computed tomography
Authors: Osamu Kuboyama, Tsunekazu Kakuta, Shigeki Kimura, Taishi Yonetsu, Kenji Suzuki, Yoshitoshi Nagata, Masahiko Goya, Yoshito Iesaka, Hideomi Fujiwara, Mitsuaki Isobe
Journal: Journal of the American College of Cardiology (2004)
Low Incidence of Myocardial Recovery After Left Ventricular Assist Device Implantation in Patients With Chronic Heart Failure
Authors: Donna M. Mancini, Ainat Beniaminovitz, Howard Levin, Katharine Catanese, Margaret Flannery, Marco DiTullio, Sergey Savin, Marie Elena Cordisco, Eric Rose, Mehmet Oz
Journal: Circulation (1998)

Background —Mechanical, histological, and biochemical improvement has been described in patients after left ventricular assist device (LVAD) support. Explantation of the LVADs without heart transplantation has been described in selected patients who received this therapy as a bridge to transplantation. Methods and Results —A retrospective review of patients receiving a mechanical bridge to transplantation at Columbia Presbyterian Hospital after July 21, 1991, was performed to determine the incidence of patients in whom the device was successfully explanted. From August 1, 1996, to February 1, 1998, we prospectively attempted to identify potential explant candidates by the use of exercise testing. During this time, we recruited 39 consecutive patients after insertion of the Thermo Cardiosystems vented electric device to participate in the following study. Approximately 3 months after device implantation, a maximal exercise test with hemodynamic monitoring and respiratory gas analysis was performed with the LVAD in the automated mode. The electric device was interfaced with a pneumatic console such that the rate could be decreased to 20 cycles/min. Hemodynamic measurements were recorded as the device rate was decreased. A repeat exercise test was then performed if the patient remained hemodynamically stable. A retrospective chart review of 111 LVAD recipients at our institution identified only 5 successful explant patients. Eighteen of the 39 patients were studied. Fifteen patients exercised with maximal device support. At peak exercise, V̇ o 2 averaged 14.5±3.6 mL · kg −1 · min −1 ; LVAD flow, 8.0±1.3 L/min; Fick cardiac output, 11.4±3.3 L/min; and pulmonary capillary wedge pressure, 13±4 mm Hg. Seven patients remained normotensive and could exercise at a fixed rate of 20 cycles/min. In these patients, peak V̇ o 2 declined from 17.3±3.9 to 13.0±6.1 mL · kg −1 · min −1 . In one of these patients, the device was explanted. Conclusions —Significant myocardial recovery after LVAD therapy in patients with end-stage congestive heart failure occurs in a small percentage of patients. Most of these patients have dilated cardiomyopathy. Exercise testing may be a useful modality to identify those patients in whom the device can be explanted.
Gauze Sponges in Abdominal Operations
Authors: J. Clarence Webster
Journal: JAMA (1913)

<h3>To the Editor</h3> —At the annual meeting of the American Gynecological Society in Baltimore, in May, 1912, Dr. Francis Wakefield of San Francisco demonstrated a method of employing gauze in laparotomies both for making a wall around the field of operation and for sponging blood and other fluids. He employed three strips of prepared gauze several yards in length fastened in pockets attached to the laparotomy sheet, the largest of the three being used to pack the intestines away from the area of operation. In routine work the gauze is fastened in the pockets of the sheet before the latter is folded and sterilized. After my return from the meeting, I immediately adopted Dr. Wakefield's procedure in my clinic in the Presbyterian Hospital, Chicago, and I am now glad to be able to recommend it most highly as a method of making it practically impossible to lose a piece of
An impaired phagocytic function is associated with leucocyte activation in the early stages of severe acute pancreatitis.
Authors: G Liras, F Carballo
Journal: Gut (1996)

BACKGROUND: An excessive leucocyte activation takes place early in severe acute pancreatitis. Furthermore, some indirect evidences suggest a disturbance of the mononuclear phagocytic system in the severe cases. AIMS: To compare the early functionalism of leucocytes obtained from patients with mild disease and severe disease, under the hypothesis that an impaired phagocytic function could be associated with the leucocyte activation. PATIENTS AND METHODS: Flow cytometric parameters of leucocyte function, such as phagocytosis, and fluorescence of leucocytes with acridine orange (FLAO) were prospectively measured together with granulocyte elastase plasma concentrations in 21 patients with severe (n = 7) and mild (n = 14) acute pancreatitis. Samples were drawn at 24 hours from admission, 48 hours, 72 hours, and on day 5. RESULTS: There was a greater leucocyte activation together with a deficient phagocytosis before 72 hours in severe patients. The results (mean (SEM)) severe v mild were: 440 (115) microgram/l v 77 (14) micrograms/l for granulocyte elastase, 2.218 (377) v 1.308 (155) for FLAO, 64 (7) v 90 (2), and 55 (9) v 81 (3) for percentages of phagocytising neutrophils and monocytes, respectively. Phagocytic capacity returned to normal later on day 5. CONCLUSIONS: The excessive leucocyte activation together with the impaired phagocytosis could be related to the onset of complications in severe acute pancreatitis.
Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Events
Authors: Evan J. H. Lewis
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Model of Its Kind
Authors: Dale C. Smith
Journal: JAMA (1989)

The authors of<i>A Model of Its Kind</i>have prepared a unique centennial history of a medical center. These volumes were clearly a labor of love, prepared to celebrate important institutions the histories of which are bound up with the last century of American medicine. The work is in three parts in two volumes. Part 1 is a chronological history of The Johns Hopkins Medical Institutions, part 2 is a series of thematic essays on what the authors view as the most significant or distinctive contributions of those institutions, and part 3 in the second volume is a collection of photographs drawn from institutional archives. The story of the founding and disproportionate influence of The Johns Hopkins University is well known to all interested in the history of American medicine or American education. A Baltimore merchant—Johns Hopkins—left his fortune to endow a hospital and a university. In a letter of
THE SUPERIORITY OF SYSTOLIC OVER DIASTOLIC BLOOD PRESSURE NON-DIPPING IN THE PREDICTION OF TARGET ORGAN DAMAGE IN ESSENTIAL HYPERTENSION: IMPLICATIONS IN DIPPING DEFINITION
Authors: Dimitris Syrseloudis, K. Tsioufis, L. Lioni, E. Andrikou, M. Giakoumis, A. Kordalis, M. Poulakis, D. Flessas, C. Stefanadis
Journal: Journal of the American College of Cardiology (2011)
Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms
Authors: Hervé Ghesquières, Guillaume Cartron, John Francis Seymour, Marie-Hélène Delfau-Larue, Fritz Offner, Pierre Soubeyran, Aurore Perrot, Pauline Brice, Réda Bouabdallah, Anne Sonet, Jehan Dupuis, Olivier Casasnovas, John Vincent Catalano, Alain Delmer, Fabrice Jardin, Aurélie Verney, Peggy Dartigues, Gilles Salles
Journal: Blood (2012)
INCREASED SMOKING AND ALCOHOL EXPOSURE IN ADOLESCENCE HAS AN ADVERSE EFFECT ON ARTERIAL STIFFNESS IN YOUNG ADULTHOOD: THE ALSPAC STUDY
Authors: Marietta Charakida, Tauseef Khan, Alicja Rapala, Frida Dangardt, George Davey Smith, Debbie Lawlor, John Deanfield
Journal: Journal of the American College of Cardiology (2014)