tbuckley/cabot-search huggingface dataset:
Kallikrein-Kinin System in Postgastrectomy Dumping Syndrome
Authors: PATRICK Y. WONG
Journal: Annals of Internal Medicine (1974)

The kallikrein-kinin system was studied in 10 postgastrectomy patients, 5 with the dumping syndrome and 5 patients without symptoms. After drinking 220 ml of 45% glucose, none of the asymptomatic patients developed symptoms of the dumping syndrome, elevated levels of bradykinin, or prekallikrein activation; the mean blood pressure fall was not significant. The symptomatic group had headaches, lightheadedness, diarrhea, and a significantly decreased mean blood pressure of 19.4%. A rise in plasma bradykinin levels to above normal occurred in all patients. Two had activation of plasma kallikrein, manifested by a drop in prekallikrein and complete disappearance of kallikrein inhibitor; one of these two also had increased free kallikrein, shown by kinin release from kininogen. The mechanism of kinin release in the other three patients is unknown. Our findings suggest that kinins may mediate some features of the dumping syndrome. In some patients kinin release seemed to result from the formation of plasma kallikrein. In others the exact mechanism of kinin release is unclear.
Hepatocellular Carcinoma in Patients With Cryptogenic Cirrhosis
Authors: Edoardo Giovanni Giannini, Elisa Marabotto, Vincenzo Savarino, Franco Trevisani, Maria Anna di Nolfo, Paolo Del Poggio, Luisa Benvegnù, Fabio Farinati, Marco Zoli, Franco Borzio, Eugenio Caturelli, Maria Chiaramonte
Journal: Clinical Gastroenterology and Hepatology (2009)
Some countries cut their own spending on health when given health aid
Authors: D. Asprey
Journal: BMJ (2010)

In many countries in sub-Saharan Africa, for every $1 (£0.65; €74) received in health aid the government reduces its spending on domestic health by between $0.43 and $1.14, says a study published in the Lancet (doi:10.1016/S0140-6736(10)60233-4). The study does not show where the diverted money goes.

While domestic spending on health care in low income countries doubled from 1995 to 2006, in the poorest countries international aid to governments is replacing domestic health budgets, freeing governments to spend on other priorities.

A systematic analysis of data on the public financing of health care obtained from the World Health Organization and International Monetary Fund found …
Value of positive technetium-99m leucocyte scans in predicting intestinal inflammation.
Authors: P Gibson, M Lichtenstein, N Salehi, G Hebbard, J Andrews
Journal: Gut (1991)

The value of positive scans of autologous 99mTc-labelled leucocytes in the detection of intestinal inflammation was assessed in 29 patients with known inflammatory bowel disease and a high probability of intestinal inflammation and 58 with a low probability of intestinal inflammation comprising 37 with intestinal symptoms and 21 with suspected abscess. Autologous leucocytes were labelled with 99mTc using either of the established methods. In patients with inflammatory bowel disease, 3/13 with ileocaecal and 1/11 with colonic accumulation of 99mTc were incorrectly diagnosed in that there was no histological evidence of inflammation in those regions. In the low probability patients, all 26 positive images were false positives: there were 19 in the ileocaecal and 7 in colonic regions and no differences between the two subgroups. False positives were more common in low probability than high probability patients (p = 0.011). The results were independent of the 99mTc cell labelling technique used. Three false positive patients also had normal scans for 111In-labelled granulocytes. The time of first detection of 99mTc in the bowel was earlier in true than in false positive patients (92% v 33% within 1 h, p = 0.008), the false positive rates in the first hour of imaging being 5% in high and 15% in low probability patients. In 99mTc scintigraphy, the appearance of the isotope in the intestine occurs commonly in the absence of inflammation irrespective of the cell labelling technique used. In high probability patients, imaging at 1 h can more reliably discriminate true from false positives and retain clinical usefulness. In low probability patients specificity remains unacceptable and 99mTc-labelled leucocyte scanning in these patients is of little value as a positive predictor of intestinal inflammation.
Periodic Physician Recredentialing
Authors: Edgar A. Suter
Journal: JAMA (1991)

To the Editor. —  Let us look at those suggesting a physician recredentialing process. First, we have Gellhorn 1 from the New York Department of Health—a government bureaucracy. Second, we have Dr Langsley 2 from the American Board of Medical Specialties—a professional bureaucracy. Both are from bureaucracies that would ascend in power over the lives and livelihoods of practicing physicians.  Recredentialing? Educational, not punitive, the recredentialing bureaucrats tell us. This won't hurt, the dentist tells us. What of the National Physician Data Bank? What of the friendly reviews of the Medicare civil servants? What of the national trial lawyers? Only those who stand to gain power and influence will tout recredentialing. Only those who hold honest jobs stand to lose. Let organized medicine not stand again as procurer for the power mongers or their dupes.
An Approach for Searching Insertions in Bacterial Genes Leading to the Phase Shift of Triplet Periodicity
Authors: Maria A. Korotkova, Nikolay A. Kudryashov, Eugene V. Korotkov
Journal: Genomics Proteomics & Bioinformatics (2011)

The concept of the phase shift of triplet periodicity (TP) was used for searching potential DNA insertions in genes from 17 bacterial genomes. A mathematical algorithm for detection of these insertions has been developed. This approach can detect potential insertions and deletions with lengths that are not multiples of three bases, especially insertions of relatively large DNA fragments (>100 bases). New similarity measure between triplet matrixes was employed to improve the sensitivity for detecting the TP phase shift. Sequences of 17,220 bacterial genes with each consisting of more than 1,200 bases were analyzed, and the presence of a TP phase shift has been shown in ∼16% of analysed genes (2,809 genes), which is about 4 times more than that detected in our previous work. We propose that shifts of the TP phase may indicate the shifts of reading frame in genes after insertions of the DNA fragments with lengths that are not multiples of three bases. A relationship between the phase shifts of TP and the frame shifts in genes is discussed.
The inhibition of human bladder cancer growth by calcium carbonate/CaIP6 nanocomposite particles delivering AIB1 siRNA
Authors: Jinhuan Wei, Tuckyun Cheang, Bing Tang, Haoming Xia, Zhouhao Xing, Zhenhua Chen, Yong Fang, Wei Chen, Anwu Xu, Shenming Wang, Junhang Luo
Journal: Biomaterials (2012)
S119 Is the hypercapnic ventilatory response still relevant to central sleep apnoea in the era of modern heart failure management?
Authors: A Atalla, TW Carlisle, AK Simonds, MR Cowie, MJ Morrell
Journal: Thorax (2013)

<h3>Introduction</h3> A brisk ventilatory response to carbon dioxide (CO<sub>2</sub>) is integral to the development of central sleep disordered breathing (SDB) in heart failure (HF) patients. Modern treatments for HF enhance cardiac function and many improve central SDB. The role of hypercapnic ventilatory responses (HCVR) in central SDB in HF patients managed according to modern guidelines is unclear. For example, adaptive servoventilation (ASV), used to treat central SDB, both improves cardiac function and reduces hypercapnic ventilatory responses (HCVR), suggesting that heightened chemosensitivity in HF may relate to cardiac impairment. <h3>Objective</h3> To test the hypothesis that there would be no difference in HCVR between optimally treated patients with HF and central SDB (HF-CSA), and those with HF alone (HF-noSDB). <h3>Method</h3> Measurements of resting expired CO<sub>2</sub> (awake) and evening and morning HCVR, using the Read rebreathe technique, were undertaken in patients optimally treated for HF. Patients also underwent overnight polysomnography. Sample size calculations (using data from Javaheri, NEJM 1999) showed 10 patients were needed in each group. Statistical analyses were undertaken using SPSS. The study received ethical approval. <h3>Results</h3> Twenty-six HF patients were studied (11 with HF-CSA: median (IQR) age 68 (58–78) and 15 with HF-noSDB: age 72 (67–78)years). Left ventricular ejection fraction was: HF-CSA 32 (20–40)% and HF-noSDB 40 (27–47)%. The apnoea hypopnoea index was: HF-CSA 14.6 (12.9–37.1)/hr and HF-noSDB 5.0 (3.2–6.0)/hr. The HF-CSA group had lower median resting expired CO<sub>2</sub> than the HF-noSDB group (end tidal CO<sub>2</sub>: 30.6 (28.6–37.3) vs. 36.2 (35.2–40.4)mmHg, p = 0.02). There was no significant difference between the HF-CSA and HF-noSDB in evening HCVR (2.15 (1.70–2.74) vs. 1.99 (1.60–3.33)L/min/mmHg ETCO<sub>2</sub>, p = 0.53) or morning HCVR (2.71 (1.43–4.88) vs. 2.20 (1.00–3.00)L/min/mmHg ETCO<sub>2</sub>, p = 0.23). Resting expired CO<sub>2</sub> in the total study population correlated negatively with morning, but not evening, HCVR. <h3>Conclusion</h3> The results of this small study suggest that modern HF management may have an effect on ventilatory stability via changes in HCVR. The timing of the HCVR tests may be a factor. We speculate that overnight disturbances in breathing may promote ventilatory instability in the morning, rather than the evening.
THE IMMUNOLOGICALLY SPECIFIC RETENTION OF RECIRCULATING LONG-LIVED LYMPHOCYTES IN LYMPH NODES STIMULATED BY XENOGENEIC ERYTHROCYTES
Authors: Donald R. Thursh, Eugene E. Emeson
Journal: The Journal of Experimental Medicine (1972)

The lymph nodes of mice actively or adoptively immunized to sheep RBC and/or chicken RBC selectively retain long-lived lymphocytes after challenge with the appropriate antigen. This retention is demonstrable within 8 hr of the time of stimulation, though it probably begins even before this, and it is essentially complete within the first 24 hr. A similar selective retention is seen in nodes regional to the injection of some nonimmunogenic substances such as turpentine, but not others such as colloidal carbon or syngeneic RBC. In animals adoptively immunized to sheep and chicken RBC simultaneously, there is a preferential accumulation of the labeled long-lived lymphocytes of donors immunized to sheep RBC in lymph nodes challenged with sheep RBC, and a preferential accumulation of lymphocytes (labeled with a different radioisotope) from donors immunized to chicken RBC in lymph nodes challenged with this antigen. This immunologically specific component is demonstrable whether the antigen is given before or after adoptive immunization, suggesting that the only labeled cells capable of specific localization in this system are those cells that normally remain in the recirculating pool. In the present experiments, 31 out of 31 sets of antigenically stimulated lymph nodes have shown radiochemical evidence of immunological specificity in the distribution of donor lymphocytes between them, while corresponding sets of nonstimulated lymph nodes have shown only small random variations in the distribution of donor cells. Two different mechanisms are postulated whereby antigenic stimulation can alter the traffic of recirculating long-lived lymphocytes through stimulated lymph nodes. One affects recirculating cells of a particular immunological specificity, while the other affects recirculating cells without regard to their immunological specificity.
Predicting global death patterns not an easy task
Authors: Kathryn Senior
Journal: The Lancet Infectious Diseases (2008)

The latest annual WHO World Health Statistics report (2008) predicts that worldwide deaths from infectious diseases, notably malaria, HIV, tuberculosis, neonatal infections, and diarrhoea, will decline by 2030. "In more and more countries, the chief causes of death are non-communicable diseases (NCDs) such as heart disease and stroke", said Ties Boerma, WHO Director of Health Statistics and Informatics (Geneva, Switzerland).
Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter.
Authors: B L Shneider, P A Dawson, D M Christie, W Hardikar, M H Wong, F J Suchy
Journal: Journal of Clinical Investigation (1995)

Sodium-dependent bile acid transport in the rat ileum is abruptly expressed at weaning. Degenerate oligonucleotides, based on amino acid sequence identities between the rat liver and hamster ileal transporters, were used to amplify a rat ileal probe. A 1.2-kb cDNA clone, which contains the full coding region (348 amino acids, 38 kD), was isolated by hybridization screening. In vitro translation yielded a 38-kD protein which glycosylated to 48 kD. Sodium-dependent uptake of taurocholate was observed in oocytes injected with cRNA. Northern blot analysis revealed a 5.0-kb mRNA in ileum, kidney, and cecum. A 48-kD protein was detected in ileal brush border membranes and localized to the apical border of villus ileal enterocytes. mRNA and protein expression, which were negligible before weaning, increased dramatically at weaning. Nuclear transcription rates for the transporter increased 15-fold between postnatal days 7 and 28. The apparent molecular weight of the transporter also increased between days 19 and 28. In summary, the developmental regulation of the rat ileal sodium-dependent bile acid cotransporter is characterized by transcriptionally regulated increases in mRNA and protein levels at the time of weaning with changes in apparent molecular weight of the protein after weaning.
Progress in Liver Disease
Authors: Harry B. Greenberg
Journal: JAMA (1970)

Whether or not the Australia antigen represents a virus remains to be established; nonetheless, identification of this antigen in the serum of hepatitis patients constitutes a fascinating development that may, hopefully, presage eradication of transfusion-induced hepatitis. Other recent developments discussed by the 51 contributors to Popper and Schaffner's book range from hepatic culture and transplantation to umbilical vein catheterization and phototherapy. Intense blue light, according to Hsia and Porto, decomposes the bilirubin in icteric serum and sometimes controls neonatal jaundice. They caution, however, against an ill effect from the degradation products. Reporting on another development, Chiandussi tells how to catheterize the umbilical vein. Umbilico-portal catheterization, he notes, permits selective splenic and portal phlebography, measurement of direct portal venous pressure, and decompression of the portal bed during hemorrhage from esophageal varices. He also notes that a physician can use the transumbilical catheter to infuse chemotherapeutic agents directly into a cancerous liver.
Dermatology for Skin of Color
Authors: Andrea L. Suárez
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histamine and duodenal ulcer: effect of omeprazole on gastric histamine in patients with duodenal ulcer.
Authors: W K Man, J N Thompson, J H Baron, J Spencer
Journal: Gut (1986)

Gastric mucosal concentrations of histamine and of its metabolic enzyme, histamine methyltransferase activity, were measured in patients with duodenal ulcer disease and patients with an apparently normal stomach and duodenum. Patients with duodenal ulcer had significantly less (p less than 0.05) mucosal histamine (median 204 nmol/g) than control subjects (median 252 nmol/g). There was no significant difference between the two groups in their histamine methyltransferase activity values. Omeprazole therapy did not significantly change mucosal histamine (+23%), histamine methyltransferase activity (+5%), histamine release before (+5%) or during (+7%) pentagastrin infusion. It significantly decreased acid secretion during pentagastrin stimulation (median -73%, p less than 0.001). Omeprazole, like cimetidine, does not stop histamine release during pentagastrin stimulation.
A REMARKABLE CASE OF VISCERAL ANOMALY AND INVERSION.
Authors: G. E. CRAWFORD
Journal: JAMA (1895)

A very remarkable and interesting case of congenital deformity and anomaly of the heart and other viscera came to my notice a few days ago at the autopsy of a young girl of 16, who had suddenly died of heart disease after a brief incidental illness of a couple of days. I had had the child under observation for about five years. Her people are ignorant Bohemians and I was not able to get much history of the case previous to that time. Though a delicate child she had not been sick much; had measles when 3 years old. They had no knowledge of her heart trouble, and did not know that there was anything the matter with her until her chest became much deformed, and this they did not notice until she was 10 years old and then attributed it to a fall, but there was no evidence that
Prediction of Childhood Pulmonary Function Using Ulna Length
Authors: Leanne M. Gauld, Johanna Kappers, John B. Carlin, Colin F. Robertson
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Pulmonary function is important in neuromuscular weakness. In children, height determines normal values. Height measurement is unreliable when neuromuscular weakness or spinal deformity is present. The aim of this study was to accurately predict pulmonary function from a limb segment measurement that is precise and reproducible. Normal males (n = 1,144) and females (n = 1,199), 5.3 to 19.6 years old, were recruited from Melbourne schools. Height, weight, ulna, forearm, tibia, and lower leg lengths were measured using a Harpenden stadiometer and calipers, and electronic scales. Three maximal expiratory maneuvers were performed. Limb measurements were highly reproducible. Linear regression on log-transformed FEV1 and FVC was used to develop prediction equations from limb measurements and age. In males FEV1 = exp (0.071 × U + 0.046 × A − 1.269), r2 = 0.86; FVC = exp (0.77 × U + 0.041 × A − 1.285), r2 = 0.86 and in females FEV1 = exp (0.072 × U + 0.041 × A − 1.272), r2 = 0.84; FVC = exp (0.078 × U + 0.037 × A − 1.315), r2 = 0.83 (U refers to ulna length and A refers to age). Precision is similar to equations using height. Ulna measurement is accessible in wheelchair-bound children. Using ulna length to predict pulmonary function should facilitate respiratory assessment in children whose height is difficult to measure.
NeuroApps: MRI Atlas of Human White Matter
Authors: Owen M. Thomas, Nasim Sheikh Bahaei
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endothelial Cell Recovery Between Comparator Polymer-Based Drug-Eluting Stents
Authors: Michael Joner, Gaku Nakazawa, Aloke V. Finn, Shawn Chin Quee, Leslie Coleman, Eduardo Acampado, Patricia S. Wilson, Kristi Skorija, Qi Cheng, Xin Xu, Herman K. Gold, Frank D. Kolodgie, Renu Virmani
Journal: Journal of the American College of Cardiology (2008)
Evaluation Of a Medication Adherence Estimator Survey Compared To Exhaled Nitric Oxide (FeNO) Levels and Asthma Control Test In Difficult-To-Treat/Severe Pediatric Asthma Patients
Authors: Jigar Patel, Vanessa Y. Cavero, Amy Perkins, Heather Minto, Maripaz B. Morales
Journal: Journal of Allergy and Clinical Immunology (2014)
(17 and 18) Rothmund-Thomson syndrome
Authors: Suzanne Alexander
Journal: British Journal of Dermatology (1974)

Journal Article (17 and 18) Rothmund‐Thomson syndrome Get access Suzanne Alexander Suzanne Alexander Barking Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Pages 62–64, https://doi.org/10.1111/j.1365-2133.1974.tb12520.x Published: 01 July 1974