Famotidine-Induced Erythema Multiforme: Cross-Sensitivity with Cimetidine
Authors: Yasuhiro Horiuchi, Kazuto Ikezawa
Journal: Annals of Internal Medicine (1999)

Letters16 November 1999Famotidine-Induced Erythema Multiforme: Cross-Sensitivity with CimetidineYasuhiro Horiuchi, MD and Kazuto Ikezawa, MDYasuhiro Horiuchi, MDTsukuba Memorial Hospital; Tsukuba City, Ibaraki, Japan (Horiuchi)Tsukuba Memorial Hospital; Tsukuba City, Ibaraki, Japan (Ikezawa)Search for more papers by this author and Kazuto Ikezawa, MDTsukuba Memorial Hospital; Tsukuba City, Ibaraki, Japan (Horiuchi)Tsukuba Memorial Hospital; Tsukuba City, Ibaraki, Japan (Ikezawa)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Histamine-2 receptor antagonists (H2 blockers) are widely used to treat gastric ulcers and the hypersecretory syndrome. These drugs are considered to have very few side effects. We describe a patient with erythema multiforme that led to serious generalized exfoliative erythroderma caused by the H2 blockers cimetidine and famotidine.In a clinic, a 68-year-old woman had received the calcium-channel blocker efonidipine for hypertension and cimetidine for reflux esophagitis and suspected gallstones. She was admitted to our hospital for detection and treatment of gallstones. Erythema multiforme lesions were noted on the extremities and abdomen. The calcium-channel blocker manidipine and ...References1. Ahmed AH, McLarty DG, Sharma SK, Masawe AE. Stevens-Johnson syndrome during treatment with cimetidine [Letter]. Lancet. 1978;2:433. CrossrefMedlineGoogle Scholar2. Warner DM, Ramos-Caro FA, Flowers FP. Famotidine (pepcid)-induced symptomatic dermatographism. J Am Acad Dermatol. 1994;31:677-8. CrossrefMedlineGoogle Scholar3. Bossi A, Romeo G, Pezzoli A. Side-effects, structure, and H2-receptor antagonists [Letter]. Lancet. 1992;339:1366. CrossrefMedlineGoogle Scholar4. Horiuchi Y, Katagiri T. Lichenoid eruptions due to the H2 blockers roxatidine and ranitidine [Letter]. J Dermatol. 1996;23:510-2. CrossrefMedlineGoogle Scholar5. Merrett AC, Marks R, Dudley FJ. Cimetidine-induced erythema annulare centrifugum: no cross-sensitivity with ranitidine. Br Med J Clin Res Ed. 1981;283:698. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Tsukuba Memorial Hospital; Tsukuba City, Ibaraki, Japan (Horiuchi)Tsukuba Memorial Hospital; Tsukuba City, Ibaraki, Japan (Ikezawa) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-induced ocular side effectsDrug-induced ocular side effectsUnusual Erythemas with Eosinophilia, Caused by H 2 -Blocker Famotidine in a Male Patient with GlioblastomaActivity of cathepsin B, D and L in rat cerebrum after cimetidine and famotidine administrationErythema Multiforme Caused by the H 2 -Blocker, RoxatidineCimetidine/famotidine 16 November 1999Volume 131, Issue 10Page: 795KeywordsAdverse reactionsDrugsErythemaFamotidineGastric ulcersHypertensionLesionsLymphocytesNizatidinePruritus Issue Published: 16 November 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...