tbuckley/cabot-search huggingface dataset:
Referrals for Chronic Kidney Disease
Authors: Richard J. Glassock
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Matrix Metalloproteinase-8 Functions as a Metastasis Suppressor through Modulation of Tumor Cell Adhesion and Invasion
Authors: Ana Gutiérrez-Fernández, Antonio Fueyo, Alicia R. Folgueras, Cecilia Garabaya, Caroline J. Pennington, Simon Pilgrim, Dylan R. Edwards, Deborah L. Holliday, J. Louise Jones, Paul N. Span, Fred C.G.J. Sweep, Xose S. Puente, Carlos López-Otín
Journal: Cancer Research (2008)

Abstract Collagenase-2 (matrix metalloproteinase-8, MMP-8) is an MMP mainly produced by neutrophils and associated with many inflammatory conditions. We have previously described that MMP-8 plays a protective role in cancer through its ability to regulate the inflammatory response induced by carcinogens. Moreover, it has been reported that experimental manipulation of the expression levels of this enzyme alters the metastatic behavior of human breast cancer cells. In this work, we have used mutant mice deficient in MMP-8 and syngenic melanoma and lung carcinoma tumor cells lines overexpressing this enzyme to further explore the putative antimetastatic potential of MMP-8. We report herein that MMP-8 prevents metastasis formation through the modulation of tumor cell adhesion and invasion. Thus, tumor cells overexpressing MMP-8 have an increased adhesion to extracellular matrix proteins, whereas their invasive ability through Matrigel is substantially reduced when compared with control cells. Analysis of MMP-8 in breast cancer patients revealed that the expression of this metalloproteinase by breast tumors correlates with a lower incidence of lymph node metastasis and confers good prognosis to these patients. On this basis, we propose that MMP-8 is a tumor protective factor, which also has the ability to reduce the metastatic potential of malignant cells in both mice and human. [Cancer Res 2008;68(8):2755–63]
Codelivery of NF-κB Decoy-Related Oligodeoxynucleotide Improves LPD-Mediated Systemic Gene Transfer
Authors: Yadi Tan, Jing-Shi Zhang, Leaf Huang
Journal: Molecular Therapy (2002)

A systemic gene delivery vector for LPD (cationic liposome–polycation–DNA) has been reported previously to transfect the pulmonary endothelium and holds promise for treating pulmonary diseases. However, the uptake of LPD by immune cells triggers a strong inflammatory response that is toxic to animals and limits transgene expression. In this study, LPD was used to codeliver phosphorothioate oligodeoxynucleotides (ODNs) containing an NF-κB consensus binding sequence with plasmid DNA carrying a reporter gene. Codelivery of a single-stranded κB ODN inhibited TNF-α induction by LPD-plasmid delivery and increased transgene expression in the lung in a dose-dependent manner. A similar effect was observed with the double-stranded ODN of the same sequence at twice the dose, and the complementary ODN (antisense) had no effect. Sequence mutation study suggested that the effect was sequence specific and these ODNs may achieve their effect through interaction with NF-κB family proteins in a decoy manner. In addition to enhancing gene transfer, these single-stranded ODNs formulated in LPD may be explored as anti-inflammatory agents.
Myocardial blood flow in patients with dilated cardiomyopathy: Quantitative assessment with velocity-encoded cine magnetic resonance imaging of the coronary sinus
Authors: Norbert Watzinger, Gunnar K. Lund, Maythem Saeed, Gautham P. Reddy, Philip A. Araoz, Ming Yang, Alan B. Schwartz, Martin Bedigian, Charles B. Higgins
Journal: Journal of the American College of Cardiology (2003)
Intussusception in Infancy and Childhood
Authors: Mark M. Ravitch
Journal: New England Journal of Medicine (1958)

WITH a detailed analysis of 152 cases of intussusception seen at the Johns Hopkins Hospital, a report of 32 patients treated primarily by barium-enema reduction has been presented.1 Since that time hydrostatic-pressure reduction of intussusception by barium enema under fluoroscopic control has been the treatment of choice in intussusception at the Johns Hopkins Hospital.2 Between the 1950 report1 and January 1, 1958, 47 additional cases of unequivocal intussusception were recognized at the Johns Hopkins Hospital. There are a number of additional cases in which the diagnosis of intussusception was strongly suspected but in which either spontaneous reduction is assumed to . . .
1034 ONCOSTATIN M STIMULATES DIRECTIONAL MIGRATION OF HUMAN HEPATIC PROFIBROGENIC CELLS
Authors: C. Busletta, E. Novo, C. Paternostro, K. Mareschi, S. Cannito, D. Povero, E. David, S. Colombatto, F. Marra, F. Fagioli, M. Pinzani, M. Parola
Journal: Journal of Hepatology (2011)
Insanity and Intemperance
Authors: D. Yellowlees
Journal: BMJ (1873)

IN the second half of the year 1871, the Glamorgan Counity Asylum received only 24 male patients, whereas 47 anid 43 were received in the preceding and succeeding half-years.Again, in the first quarter of the year I873, the same asylum received only io male patients, whereas 21 and i8 were received in the preceding and succeeding quarters.While
Myelodysplasia is in the niche: novel concepts and emerging therapies
Authors: E Bulycheva, M Rauner, H Medyouf, I Theurl, M Bornhäuser, L C Hofbauer, U Platzbecker
Journal: Leukemia (2014)

Myelodysplastic syndromes (MDSs) represent clonal disorders mainly of the elderly that are characterized by ineffective hematopoiesis and an increased risk of transformation into acute myeloid leukemia. The pathogenesis of MDS is thought to evolve from accumulation and selection of specific genetic or epigenetic events. Emerging evidence indicates that MDS is not solely a hematopoietic disease but rather affects the entire bone marrow microenvironment, including bone metabolism. Many of these cells, in particular mesenchymal stem and progenitor cells (MSPCs) and osteoblasts, express a number of adhesion molecules and secreted factors that regulate blood regeneration throughout life by contributing to hematopoietic stem and progenitor cell (HSPC) maintenance, self-renewal and differentiation. Several endocrine factors, such as erythropoietin, parathyroid hormone and estrogens, as well as deranged iron metabolism modulate these processes. Thus, interactions between MSPC and HSPC contribute to the pathogenesis of MDS and associated pathologies. A detailed understanding of these mechanisms may help to define novel targets for diagnosis and possibly therapy. In this review, we will discuss the scientific rationale of 'osteohematology' as an emerging research field in MDS and outline clinical implications.
Tufted hair folliculitis. A study of four cases
Authors: J. LUELMO-AGUILAR, U. GONZALEZ-CASTRO, A. CASTELLS-RODELLAS
Journal: British Journal of Dermatology (1993)

Journal Article Tufted hair folliculitis. A study of four cases Get access J. LUELMO‐AGUILAR, J. LUELMO‐AGUILAR Service of Dermatology, Hospital General Vall d'Hebron, Barcelona, Spain Dr J. Luelmo‐Aguilar, Servicio de Dermatologia, Hospital General Vall d'Hebron, Pg. Vall d'Hebron s/n, 08035 Barcelona, Spain. Search for other works by this author on: Oxford Academic Google Scholar U. GONZALEZ‐CASTRO, U. GONZALEZ‐CASTRO Service of Dermatology, Hospital General Vall d'Hebron, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar A. CASTELLS‐RODELLAS A. CASTELLS‐RODELLAS Service of Dermatology, Hospital General Vall d'Hebron, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 128, Issue 4, 1 April 1993, Pages 454–457, https://doi.org/10.1111/j.1365-2133.1993.tb00210.x Published: 01 April 1993 Article history Accepted: 17 May 1992 Published: 01 April 1993
Prognosis in Essential Hypertension
Authors: Robert Sterling Palmer, Dorothea Loofbourow, Carl R. Doering
Journal: New England Journal of Medicine (1948)

CONSCIENTIOUS interval evaluation of sympathectomy for essential hypertension by comparison with control material is progressively defining the limitations and the applicability of this procedure.1 , 2 The same attention to control material is required when one considers the usefulness of very restrictive diets, interest in which has recently revived.3 , 4 Before applying these diets generally and indiscriminately, we should ask ourselves what the remote effects will be on the body electrolyte economy, on work capacity and hot-weather tolerance, on resistance to infection, on the basal metabolism, on carbohydrate tolerance and on fetal health in pregnancy. Finally and practically, how often is an extremely . . .
Use of fertility drugs and risk of ovarian cancer: Danish population based cohort study
Authors: A. Jensen, H. Sharif, K. Frederiksen, S. K. Kjaer
Journal: BMJ (2009)

<b>Objective</b> To examine the effects of fertility drugs on overall risk of ovarian cancer using data from a large cohort of infertile women. <b>Design</b> Population based cohort study. <b>Setting</b> Danish hospitals and private fertility clinics. <b>Participants</b> 54 362 women with infertility problems referred to all Danish fertility clinics during 1963-98. The median age at first evaluation of infertility was 30 years (range 16-55 years), and the median age at the end of follow-up was 47 (range 18-81) years. Included in the analysis were 156 women with invasive epithelial ovarian cancer (cases) and 1241 subcohort members identified in the cohort during follow-up in 2006. <b>Main outcome measure</b> Effect of four groups of fertility drugs (gonadotrophins, clomifene citrate, human chorionic gonadotrophin, and gonadotrophin releasing hormone) on overall risk of ovarian cancer after adjustment for potential confounding factors. <b>Results</b> Analyses within cohort showed no overall increased risk of ovarian cancer after any use of gonadotrophins (rate ratio 0.83, 95% confidence interval 0.50 to 1.37), clomifene (1.14, 0.79 to 1.64), human chorionic gonadotrophin (0.89, 0.62 to 1.29), or gonadotrophin releasing hormone (0.80, 0.42 to 1.51). Furthermore, no associations were found between all four groups of fertility drugs and number of cycles of use, length of follow-up, or parity. <b>Conclusion</b> No convincing association was found between use of fertility drugs and risk of ovarian cancer.
Graded global ischemia and reperfusion. Cardiac function and lactate metabolism.
Authors: C S Apstein, L Deckelbaum, M Mueller, L Hagopian, W B Hood
Journal: Circulation (1977)

The effect of global ischemia of different degrees of severity and reperfusion was studied in the isolated working rat heart. Four degrees of ischemia were induced by reducing the control total coronary flow of 8 ml/min to 0, 0.04, 0.4, or 0.8 ml/min for 30 minutes, after which the coronary flow was returned to the control level. After severe ischemia (0 and 0.04 ml/min ischemic coronary flow groups), recovery of contractility was to less than 30% of the control, pre-ischemic value of ventricular developed pressure and dP/dt, and irreversible cardiac contracture and an increased pacing threshold occurred. After moderate ischemia (0.4 and 0.8 ml/min ischemic coronary flow groups), contractile function recovered completely, ischemic contracture was rapidly reversible and the pacing threshold did not increase. The moderately ischemic groups were able to function at a stable, low level of contractility for the 30 minute ischemic period, whereas the severely ischemic groups had no contractile activity. The amount of calculated tissue lactate accumulation correlated with the occurrence of irreversible ischemic injury; the severely ischemic groups which failed to recover with reperfusion accumulated 3-5 times as much lactate as the moderately ischemic groups which recovered completely. The results suggest that relatively small differences in the severity of the ischemic condition can markedly affect the degree of tissue injury.
Monitoring adherence to beclomethasone in asthmatic children and adolescents through four different methods
Authors: N. S. Jentzsch, P. A. M. Camargos, E. A. Colosimo, J. Bousquet
Journal: Allergy (2009)

Suboptimal adherence to inhaled steroids is a known problem in children and adolescents, even when medications are administered under parental supervision. This study aimed to verify the adherence rate to beclomethasone dipropionate (BDP) by four currently available methods.In this concurrent cohort study, 102 randomly selected asthmatic children and adolescents aged 3-14 years were followed for 12 months. Adherence rate was assessed every 2 months by self and/or parent report, pharmacy dispensing data, electronic device (Doser); Meditrack Products, Hudson, MA, USA) monitor, and canister weight.Mean adherence rates to BDP by self and/or parent report, pharmacy records, Doser, and canister weight were 97.9% (95% CI 88.0-98.6), 70.0% (95% CI 67.6-72.4), 51.5% (95% CI 48.3-54.6), and 46.3% (95% CI 44.1-48.4), respectively. Agreement analysis between (Doser) and canister weight revealed a weighted kappa equal to 0.76 (95% CI 0.65-0.87).Adherence was a dynamic event and rates decreased progressively for all methods over the 12-month follow-up. Canister weight and electronic monitoring measures were more accurate than self/parent reports and pharmacy records. Rates obtained by these two methods were very close and statistical analysis also showed a substantial agreement between them. As measurements by canister weight are less costly compared with currently available electronic devices, it should be considered as an alternative method to assess adherence in both clinical research and practice.
Rarer Manifestations of Herpes Zoster
Authors: E. Guthaner
Journal: BMJ (1948)

of Raffaele's findings by saying that they have not been confirmed or received any support.But it is just that negative assumption that needs support, a support that would exact a long painstaking work as was Raffaele's work.I am sure that your readers may be surprised in learning from Davey that to succeed in finding these forms, with the same diffi- culties that one meets in finding them in a six-days-old chick, it would be necessary to inoculate in the human the contents of 50,000 infected salivary glands.All malariologists who took the trouble of looking at Raffaele's smears have not hesitated in con- sidering them as belongfng to the exo-erythrocytic stage.I think that the authors' findings in the monkey is a confirmation of Raffaele's work on man.By the way, owing to the authority of Raffaele in that field his observations should have been accepted.
Genetics white paper heralds "a revolution in health care"
Authors: K. Godfrey
Journal: BMJ (2003)

Data from the Oxford Record Linkage Study were analysed to determine the amount of work undertaken in day case surgery for 12 surgical conditions in five districts in the Oxford Region during the years 1976 to 1985. Record linkage was used to study readmission rates, comparing day surgery with inpatient care. The use of day surgery gradually increased in some conditions (eg, termination of pregnancy, female sterilisation) but did not increase from a fairly low base for others (eg, inguinal hernia repair, operations on varicose veins and haemorrhoids). There were striking differences between the districts in the use of day case care. For example, the use of day case care as a percentage of all hospital admissions for termination of pregnancy varied from 1% in one district to 24% in another; that for dilatation and curettage varied from 1% to 43%; and that for female sterilisation varied from less than 1% to 35%. Emergency readmission rates after day surgery were similar to those following inpatient treatment. We conclude that the use of day surgery for some conditions judged suitable for day care is still low and, even within one region, variation in the use of day surgery is considerable. The reasons for continued reluctance in some places to undertake more day surgery merit investigation.
Effect of Prior Cancer Chemotherapy on Human Tumor-Specific Cytotoxicity In Vitro in Response to Immunopotentiating Biologic Response Modifiers
Authors: L. M. Weisenthal, P. L. Dill, F. C. Pearson
Journal: JNCI Journal of the National Cancer Institute (1991)

Tumor-specific cytotoxicity was measured in fresh human biopsy specimens by a modification of the differential staining cytotoxicity assay. Imuvert, a cytokine inducer derived from Serratia marcescens, which produces broad-spectrum activation of both macro-phages and lymphocytes, was dramatically more effective when it was tested in tumors obtained from patients with previously treated, chemotherapy-responsive adenocarcinomas (breast and ovary) than when it was tested in tumors obtained from either previously untreated patients or previously treated patients with chemotherapy-refractory adenocarcinomas (colon, lung, pancres, stomach, kidney, gallbladder, uterus, and prostate). Similar findings, relating to prior chemotherapy treatment status, were obtained for tumor necrosis factor and interferon Y, but not for interleukin-2 or interferon a. On the basis of these findings and on other evidence in the literature, we speculate that response to chemotherapy produces massive release and processing of tumor antigens. We further speculate that this response leads to a state in which the human immune system is primed (via in situ vaccination) to respond to exogenous macrophage-activation signals with potent, specific antitumor effects. [J Natl Cancer Inst 83:37–42, 1991]
Patients can be made to have HIV test to protect doctor
Authors: Tony Sheldon
Journal: BMJ (2004)

Dutch doctors have welcomed a Supreme Court ruling that a patient can be ordered to give blood for an HIV test in order to limit injury to a doctor during treatment.

After an appeal process lasting more than two years, the court concluded that the need to limit the damage to a doctor outweighed the relatively minor infringement of the patient's rights.

The judgment goes beyond previous similar cases, which involved a rape or biting by someone suspected of being HIV positive. In such cases, a …
Extracorporeal lung assist might avoid invasive ventilation in exacerbation of COPD: Table 1–
Authors: Jörg Brederlau, Thomas Wurmb, Stefan Wilczek, Kirstin Will, Sebastian Maier, Markus Kredel, Norbert Roewer, Ralf M Muellenbach
Journal: European Respiratory Journal (2012)

Extracorporeal lung assist might avoid invasive ventilation in exacerbation of COPDTo the Editors:Acute exacerbation of chronic obstructive pulmonary disease (COPD) requiring invasive mechanical ventilation (IMV) is associated with a very poor prognosis.Therefore noninvasive mechanical ventilation (NIV) with avoidance of endotracheal intubation should be preferred.However, NIV can fail and result in severe respiratory acidosis.If IMV becomes mandatory, the development of pulmonary dynamic hyperinflation with subsequent barotrauma and circulatory failure is the main pathophysiological alteration.
Response to Comment on Lopes-Virella et al. Baseline Markers of Inflammation Are Associated With Progression to Macroalbuminuria in Type 1 Diabetic Subjects. Diabetes Care 2013;36:2317–2323
Authors: Maria F. Lopes-Virella, Nathaniel L. Baker, Kelly J. Hunt, Patricia A. Cleary, Richard Klein, Gabriel Virella
Journal: Diabetes Care (2014)

We appreciate the comments of Drs. Jialal and Devaraj (1) on our article (2). Our study was run concomitantly with the study reported by Joslin investigators (3) and reached similar conclusions concerning the predictive value of soluble tumor necrosis factor (TNF) receptors in nephropathy progression. We mentioned their results in our discussion. We did not mention the possible role of increased Toll-like receptor (TLR) activity in triggering the TNF pathway as other alternative explanations could better explain our findings. We previously published data showing that oxidized LDL immune complexes (oxLDL-ICs) are associated with and predict the development of proteinuria (4) and that oxLDL-ICs are much stronger activators of the TNF pathway than oxLDL, which activates innate immunity through the interaction with TLR-4 (5).

The concern over the relationship between soluble vascular cell adhesion …
The Contribution of the Levator Ani Nerve and the Pudendal Nerve to the Innervation of the Levator Ani Muscles; a Study in Human Fetuses
Authors: Christian Wallner, Julia van Wissen, Cornelis P. Maas, Noshir F. Dabhoiwala, Marco C. DeRuiter, Wouter H. Lamers
Journal: European Urology (2007)
Localized collapsing cues can steer growth cones without inducing their full collapse
Authors: Jinhong Fan, Jonathan A Raper
Journal: Neuron (1995)

Collapsing factors are proteins that induce growth cone collapse and paralysis when added in a soluble form to cultured embryonic neurons. Here we examine the responses of growth cones to localized collapsing signals. Temporal retinal ganglion cell growth cones exposed to a localized collapsing stimulus from nasal retinal ganglion cell axons frequently turn smoothly away from the axons without collapsing. Turning is rare on contact with retinal axons that are unable to induce collapse. In a separate series of experiments, dorsal root ganglion growth cones tend to turn away from beads coated with a brain extract enriched for the motility-inhibiting protein collapsin. Many turns are accomplished with filopodial contact alone. Growth cones do not turn away from control beads coated with heat-inactivated collapsin. These results suggest that inhibitory guidance cues can steer growth cones through a localized inhibition of lamellipodial protrusion.
Spending more on trauma care doesn't improve survival, study finds
Authors: J. H. Tanne
Journal: BMJ (2012)

Western US states spend a third more than northeastern states on trauma care, but survival rates are just the same, a new study says.1 It suggests that rising healthcare costs could be reined in if doctors learnt how colleagues in low cost regions treat their patients.

Wide geographical variations in care and costs for various conditions have previously been identified by the Dartmouth Health Atlas.2 

The latest study, from the Johns Hopkins School of Medicine in Baltimore, was led by the trauma surgeon Adil Haider. Although initial trauma resuscitation has been significantly standardised across the United States, the study says that …