tbuckley/cabot-search huggingface dataset:
Abstract 9124: Cardiopulmonary Exercise Testing to Evaluate Consequences of Transcutaneous Pulmonary Valve Implantation.
Authors: Anjan Batra, Dan Cooper, Richard Zakheim, Curt Daniels, Delphine Yung, Robert Garfano, Jonathan Rhodes
Journal: Circulation (2010)

Introduction: Transcutaneous pulmonary valve (TCPV) provides a new tool for improving conduit stenosis and regurgitation in patients with right ventricle to pulmonary artery conduit dysfunction. We...
TCT-651 Non-Culprit Lesion Morphology in ST-Segment Elevation Myocardial Infarction and Stable Angina Pectoris: an Optical Coherence Tomography Fibrous Cap Volumetric Analysis
Authors: Micheli Z. Galon, Zhao Wang, Guilherme F. Attizzani, David L. Wilson, Andrew M. Rollins, Pedro A. Lemos, Hiram Bezerra
Journal: Journal of the American College of Cardiology (2013)
Social factors and marital pathology.
Authors: J Dominian
Journal: BMJ (1979)

Marital breakdown is a widespread phenomenon, which has considerably accelerated in the past 20 years, and occurs in most countries with a Western culture. Students of this phenomenon have asserted that common factors must be operating in each country but are hesitant to state with any confidence what these factors are. The factors responsible can be separated into two groups; general or global; and specific.1
Salmonella Strains With Transferable Antimicrobial Resistance
Authors: Fred A. Gill
Journal: JAMA (1966)

The pattern of antimicrobial resistance was determined for 254 strains of<i>Salmonella</i>isolated from clinical sources. Thirty-five strains were found to be markedly resistant to ampicillin, chloramphenicol, tetracycline, streptomycin, or sulfisoxazole. Twenty-five of the resistant strains were capable of transferring resistance to a sensitive strain of<i>Escherichia coli</i>during mixed cultivation. Resistance for one, two, three, or four antimicrobial compounds could be transferred. The levels of antimicrobial resistance transferred to the recipient strains of E coli were identical with those of the donor strains of Salmonella. It is apparent from these and other observations that Enterobacteriaceae capable of transferring resistance factors for single or multiple antimicrobial drugs by bacterial conjugation are widespread in the environment.
Elastin Structure, Biosynthesis, and Relation to Disease States
Authors: Lawrence B. Sandberg, Norman T. Soskel, John G. Leslie
Journal: New England Journal of Medicine (1981)

Elastin, a component of connective tissue, is present in virtually every organ of the body. Its role is unique and undoubtedly important, even though it may make up only a small percentage of a tissue. Its role is being appreciated increasingly in the pathogenesis of atherosclerosis, emphysema, and other diseases.Definitions and MorphologyElastin is the functional protein component of the elastic fiber, the component of connective tissue that has an amorphous, highly refractive, generally wavy appearance under the light microscope. When elastin is stretched, its waviness disappears and it takes on increased birefringence, which is usually attributed to a . . .
Stepping backward to improve assessment of PCB congener toxicities.
Authors: L G Hansen
Journal: Environmental Health Perspectives (1998)

Polychlorinated biphenyls (PCBs) are ubiquitous global contaminants that have been intensively investigated for three decades. They are broad-acting toxicants occurring in complex mixtures and accurate risk assessment has proven to be elusive. Focusing on a limited set of end points and emphasizing a fixed set of congeners have led to more streamlined data sets that are meant to expedite hazard characterization and risk assessment for the most potent congeners--aryl hydrocarbon receptor (AhR) agonists. Unfortunately, this has made it impossible to confirm or deny significant contributions from the more prevalent components of the mixtures. PCBs may be only coincidentally present, rather than causal, in some diseases. Still, attempts to determine associations with incomplete residue data may lead to erroneous conclusions and make accurate risk assessment even more elusive. Responses not mediated through the AhR are presented and emphasize large data gaps. Dissimilar analytical reports emphasize that selection of analytes is not consistent. Collectively, these data confirm that AhR-focused objectives unintentionally created the impression that nonplanar PCBs have little if any potential for hazards to humans and wildlife. Near steady-state exposure of healthy adults are probably of minor consequence except for emerging correlations with non-Hodgkin's lymphoma; however, pulses of exposure to more labile mixtures may contribute to developmental effects without leaving a residue record. More broadly based criteria are suggested and harmonization of data collection and presentation are desirable. A more comprehensive list of PCB congeners is proposed that would provide more adequate data upon which to base associations with adverse outcomes.
The Fibromatous Prostate
Authors: R. Harrison
Journal: BMJ (1889)

9 out of the 84 operations needed a second dressing; the dressing first applied being one of salicylic or "'salufer " wool held in posi- tion by a gauze bandage.Out of 63 divisions of the femur for genu valgum, in only 1 was any,pus seen, and in that case, a small piece of necrosed bone, about the size of a sixpence, came away, but the patient ulti- mately did well.Of the tibial cases, two suppurated and required a number of dressings, and in one of these the ends of the bone had to be re- freshed.In these two cases the saw was used instead of the chisel.Except in the three cases which suppurated, the tempera- ture was normal.The ultimate results, so far as the straightness of the limbs is'concerned, [have been very satisfactory; but it was
A1.80 Alterations in gait profile and bone marrow inflammation before the onset of collagen-induced arthritis
Authors: K Sinn, C Aschauer, T Shvets, B Niederreiter, J Smolen, K Redlich, S Hayer
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Chronic inflammation of joints ulimatively leads to bone and cartilage damage resulting in functional impairment or even complete disabilities of joints in RA patients. <h3>Purpose</h3> (I) To assess objective, quantitative functional impairment in joints in collagen-induced arthritis, we performed longitudinal CatWalk-assisted gait profiles from mice before the onset and during the course of collagen-induced arthritis. (II) To address preclinical inflammatory changes before the onset of arthritis based on altered gait profiles. <h3>Material and Methods</h3> Mice were immunised i.d. with bovine type II collagen (100µg) in presence of CFA in 8 week old male DBA1/J mice. After 3 weeks mice were boosted i.p. with type II coll (100µg) in PBS. CatWalk-assisted gait profiles were performed from immunised and non-immunised animals on day 14, 22, 27, 29, 33, 37, 41, 43 and 70 after first immunisation. Body weight and clinical signs of arthritis including paw swelling and grip strength were also evaluated at these time points. To assess inflammatory joint damage, we quantitatively assessed the extend of synovial inflammation, subchondral bone erosion and cartilage damage on hematoxylin &amp; eosine (H&amp;E), tartrate-resistant acid phosphatase (TRAP) and toluidine-blue stained paw sections at preclinical stages, d7, d14 and d40 after the boost injection. Neutrophil accumulation was analysed by immunohistochemical staining of hind paw sections. <h3>Results</h3> To assess functional impairment, we established CatWalk-asssisted gait profiles during the course of the disease ranging from the day 14 until day 70 after the first immunisation. Expectedly, we observed significant changes in various gait parameters including print length, maximal intensity,… in front and hind paws during the acute phase of the disease. Most of the parameters show subsequent decline in the chronic phase the disease. Next, to evaluate alterations in gait profiles before the onset of clinical signs of arthritis, we assessed gait profiles every 2<sup>nd</sup> day after the boost injection. Of note, we found significant changes in individual parameters including maximum contact area (mm<sup>2</sup>), maximum contact max intensity, print width and print area even before the onset of paw swelling (1-3 days before). Histological analysis of hind paws from this preclinical stage revealed bone marrow accumulations of immune cells, in particular neutrophil granulocytes, but no obvious synovial hyperplasia or infiltration of immune cells into the synovial membrane. <h3>Conclusion</h3> Functional impairment assessed by video-based Catwalk gait analysis occurs before the onset of clinical signs of arthritis and is linked to neutrophil accumulations in the bone marrow.
Predicting Treatment Response in Social Anxiety Disorder From Functional Magnetic Resonance Imaging
Authors: Oliver Doehrmann, Satrajit S. Ghosh, Frida E. Polli, Gretchen O. Reynolds, Franziska Horn, Anisha Keshavan, Christina Triantafyllou, Zeynep M. Saygin, Susan Whitfield-Gabrieli, Stefan G. Hofmann, Mark Pollack, John D. Gabrieli
Journal: JAMA Psychiatry (2012)

Context: Current behavioral measures poorly predict treatment outcome in social anxiety disorder (SAD).To our knowledge, this is the first study to examine neuroimaging-based treatment prediction in SAD.Objective: To measure brain activation in patients with SAD as a biomarker to predict subsequent response to cognitive behavioral therapy (CBT).Design: Functional magnetic resonance imaging (fMRI) data were collected prior to CBT intervention.Changes in clinical status were regressed on brain responses and tested for selectivity for social stimuli.Setting: Patients were treated with protocol-based CBT at anxiety disorder programs at Boston University or Massachusetts General Hospital and underwent neuroimaging data collection at Massachusetts Institute of Technology.Patients: Thirty-nine medication-free patients meeting DSM-IV criteria for the generalized subtype of SAD.Interventions: Brain responses to angry vs neutral faces or emotional vs neutral scenes were examined with fMRI prior to initiation of CBT.Main Outcome Measures: Whole-brain regression analyses with differential fMRI responses for angry vs neutral faces and changes in Liebowitz Social Anxiety Scale score as the treatment outcome measure.Results: Pretreatment responses significantly predicted subsequent treatment outcome of patients selectively for social stimuli and particularly in regions of higher-order visual cortex.Combining the brain measures with information on clinical severity accounted for more than 40% of the variance in treatment response and substantially exceeded predictions based on clinical measures at baseline.Prediction success was unaffected by testing for potential confounding factors such as depression severity at baseline. Conclusions:The results suggest that brain imaging can provide biomarkers that substantially improve predictions for the success of cognitive behavioral interventions and more generally suggest that such biomarkers may offer evidence-based, personalized medicine approaches for optimally selecting among treatment options for a patient.
Sputum Cytology After Inhalation of Heated Propylene Glycol
Authors: C. Robert Olsen
Journal: JAMA (1961)

EXAMINATION of the cellular components of the sputum has gained an established role in the diagnosis of carcinoma of the lung. Although as high as 50 per cent of the persons in a random population raise sputum every day,<sup>1</sup>the cytologic method still cannot be applied to a large number of patients unable to raise sputum. The potential value of sputum cytology has resulted in various attempts to induce a productive cough. One successful method, the inhalation of sulfur dioxide,<sup>2</sup>is frequently associated with annoying side effects. Another recent technique, the inhalation of a heated aqueous propylene glycol aerosol, has been reported to be effective and relatively nontraumatic.<sup>3-5</sup>We have selected the latter method for further clinical trial. <h3>Methods</h3> Classifications on consecutive sputa submitted from patients during a 15-month period from January, 1960, to April, 1961, were correlated with the clinical data. Patients were excluded if less
TRICHINOSIS WITH INVOLVEMENT OF THE CENTRAL NERVOUS SYSTEM
Authors: Joseph Salan
Journal: JAMA (1928)

A case of trichinosis with involvement of the central nervous system is reported here as another clinical contribution to the literature of trichinosis encephalitis. That this form of encephalitis eixsts as a clinical entity was demonstrated by Frothingham<sup>1</sup>in 1906 and by Hassin<sup>2</sup>in a pathologic report in 1926. The older writers<sup>3</sup>speak of rigidity of the neck, Kernig's sign, the paraplegias, singultus and trismus as occurring in trichinosis. These signs, however, can be explained by local irritation in the muscles due to the presence of the trichinae, and not as necessarily due to involvement of the menginges or central nervous system. In reviewing the literature on trichinosis, if the review is limited to the cases presenting neurologic manifestations, one finds that very little has been written on the subject. Even the discovery of the trichinae in the spinal fluid by Lintz and VanCott<sup>4</sup>in 1913
Histiocytosis X in two infants—treated with topical nitrogen mustard
Authors: HUGH ZACHARIAE
Journal: British Journal of Dermatology (1979)

Journal Article Histiocytosis X in two infants—treated with topical nitrogen mustard Get access HUGH ZACHARIAE HUGH ZACHARIAE Department of Dermatology, Marselisborg Hospital, University of Aarhus, 8000 Aarhus, Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 100, Issue 4, 1 April 1979, Pages 433–438, https://doi.org/10.1111/j.1365-2133.1979.tb01645.x Published: 01 April 1979
TCT-466 Clinical impact of the use of thrombus aspiration devices in primary angioplasty. Insights from the multicentric study ESTROFA-MI
Authors: Jose De la Torre Hernandez, Fernando Alfonso, Victoria Martin Yuste, Angel Sanchez Recalde, Manuel Jimenez Navarro, Armando Pérez de Prado, Hernandez Felipe, Omar Abdul-Jawad Altisent, Neus Salvatella, Tamara Garcia Camarero, Jaime Elizaga, Ramon Calviño, Jose Moreu, Francisco Bosa, Jesus Jimenez Mazuecos, Jose Ruiz Arroyo, Bruno Garcia de Blanco, Jose Rumoroso
Journal: Journal of the American College of Cardiology (2012)
The General Practitioner and the Psychiatrist
Authors: N. J. Bodkin, R. B. Gaze, G. Gomez, M. J. Howlett, D. Leigh
Journal: BMJ (1953)

Background/Aim: Distinguishing between primary and metastatic adenocarcinomas in the lung may sometimes be difficult by conventional histopathological methods. In addition, novel biomarkers are needed for the more accurate subtyping of primary lung carcinomas. Materials and Methods: MicroRNA microarrays were performed on 26 primary lung adenocarcinomas, 3 squamous cell carcinomas, 6 small cell lung cancers (SCLCs), and 2 colorectal cancer metastases in the lung. Results: Forty-four microRNAs differentially expressed between three histological subtypes at p&lt;10<sup>−6</sup> predicted histology with 100% accuracy in 100 randomly drawn datasets. Prominent among differentially expressed genes were miR-375, miR-217 and miR-216a, which were found overexpressed in SCLC compared to lung adenocarcinomas. Lung adenocarcinomas overexpressed miR-29b-1, miR-375, miR-2110, miR-29c-star, 199b-5p, and 146b-3p and underexpressed miR-617, miR-205-star, and miR-1246 compared to squamous cell carcinomas. In primary vs. metastatic lung adenocarcinomas, miR-552 and miR-592 were differentially expressed at p&lt;10<sup>−6</sup>; the level of expression of miR-552 in colorectal cancer metastases was 39-times higher and that of miR-592 was six-times higher. Furthermore, microRNA profiles of primary colorectal cancer in our database indicated that these two microRNAs were overexpressed in primary colorectal cancer relative to primary lung adenocarcinomas. Conclusion: MicroRNA profiles predict the histology of primary lung carcinomas, and differentiate between primary lung adenocarcinomas and colorectal cancer metastases.
Montelukast for Chronic Asthma in 6- to 14-Year-Old Children
Authors: Barbara Knorr, Jonathan Matz, Jonathan A. Bernstein, Ha Nguyen, Beth C. Seidenberg, Theodore F. Reiss, Allan Becker, None for the Pediatric Montelukast Study Group
Journal: JAMA (1998)

Context.—Leukotrienes are important mediators of asthma by causing bronchoconstriction, mucous secretion, and increased vascular permeability. Studies using compounds that block leukotrienes have demonstrated improvement in asthma control in adults and adolescents, but children younger than 12 years, for whom asthma is the most common chronic disease, have not been studied.Objective.—To determine the clinical effect of montelukast, a leukotriene receptor antagonist, in 6- to 14-year-old children with asthma.Design.—Eight-week, multicenter, randomized, double-blind study.Setting.—Forty-seven outpatient centers at private practices and academic medical centers in the United States and Canada.Patients.—A total of 336 children with forced expiratory volume in 1 second (FEV1) between 50% to 85% of the predicted value, at least 15% reversibility after inhaled β-agonist administration, a minimal predefined level of daytime asthma symptoms, and daily β-agonist use. Concomitant inhaled corticosteroids at a constant daily dose were used by 39% of patients receiving montelukast and 33% receiving placebo.Intervention.—After a 2-week placebo run-in period, patients received either montelukast (5-mg chewable tablet) or matching-image placebo once daily at bedtime for 8 weeks.Main Outcome Measure.—Morning FEV1 percent change from baseline.Results.—Mean morning FEV1 increased from 1.85 L to 2.01 L in the montelukast group and from 1.85 L to 1.93 L in the placebo group. This represents an 8.23% (95% confidence interval [CI], 6.33% to 10.13%) increase from baseline in the montelukast group and a 3.58% (95% CI, 1.29% to 5.87%) increase from baseline in the placebo group (P<.001 for montelukast vs placebo).Conclusion.—Montelukast improves morning FEV1 in 6- to 14-year-old children with chronic asthma.
Supreme Court rules that FDA cannot regulate tobacco industry
Authors: S. Gottlieb
Journal: BMJ (2000)

The United States Supreme Court, rejecting the Clinton administration's unprecedented effort to control how cigarettes are sold and marketed in the United States, has ruled that the Food and Drug Administration (FDA) lacks the power to regulate tobacco.In the 5 to 4 ruling, the judges said that the FDA overreached its authority when it reversed a decades old policy in 1996 and sought to crack down on cigarette sales to minors."By no means do we question the seriousness of the problem that the FDA has sought to address," Justice Sandra Day O'Connor wrote for the court."The agency has amply demonstrated that tobacco use, particularly among children and adolescents, poses perhaps the single most significant threat to public health in the United States."However, she added, "It is plain that Congress has not given the FDA the authority that it seeks to exercise here."Justice O'Connor was joined in her opinion by the Supreme Court's more politically conservative jurists
Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin.
Authors: C L Williams, V A Lennon
Journal: The Journal of Experimental Medicine (1986)

Striational autoantibodies (StrAb), which react with elements of skeletal muscle cross-striations, occur frequently in patients with thymoma associated with myasthenia gravis (MG). Dissociated thymic lymphocytes from 22 of 72 MG patients secreted StrAb when cultured with PWM. A high yield of EBV-transformed B cell lines was established from thymus, thymoma, and peripheral blood of seven patients with MG, but clones secreting StrAb arose only from the three patients who had StrAb in their sera. The monoclonal StrAb bound to A bands or I bands in skeletal muscle of human, rat, and frog. One bound to mitochondria in addition to myofibrillar I bands. None bound to nuclei, smooth muscle, or gastric mucosal cells. In immunoblot analyses and ELISAs the monoclonal StrAb bound to muscle and nonmuscle isotypes of myosin, alpha actinin, and/or actin. All bound to contractile proteins common to thymus and muscle, and one selectively immunostained epithelial cells of the thymic medulla. From these antigenic specificities we suggest that StrAb might arise as an immune response directed against the cytoskeletal anchoring proteins associated with nicotinic acetylcholine receptors in thymic epithelial cells undergoing neoplastic transformation to thymoma.
Generation of Heat‐Labile Chemotactic Activity in Blood after Inhalation Challenge and its Relationship to Neutrophil and Monocyte/Macrophage Turnover and Activity
Authors: Per Venge, Ronald Dahl, Lena Håkansson, Christer Pettersson
Journal: Allergy (1982)

The chemotactic activity of serum has been monitored in eight patients with bronchial asthma after inhalation of an allergen. Lactoferrin and lysozyme were measured in serum simultaneously as markers of neutrophil and monocyte/macrophage activity and turnover. The heat‐labile chemotactic activity of serum showed a two‐phase response with an initial reduction in activity (median = 37.5 min after challenge) ( P &lt; 0.05) followed by an increased activity (median = 60 min after challenge) ( P &lt; 0.01). The consistency of this pattern was highly significant ( P &lt; 0.0005). Heat‐stable chemotactic activity was significantly increased ( P &lt; 0.01) 15 min after challenge. The initial reduction in heat‐labile chemotactic activity was observed only in those patients who developed a late asthmatic response and could suggest the involvement of immune complex‐mediated reactions since a similar reduction in heat‐labile chemotactic activity is produced by in vitro activation of serum with aggregated IgG. The increased heat‐labile chemotactic activity showed a close relationship ( P &lt; 0.01) to the extent of the immediate reduction in PEF‐rate. No relationship was discernible between the chemotactic activity and the eventually occurring rise in PMN blood count. In contrast the activity and turnover of PMNs after challenge as reflected by serum‐lactoferrin levels were significantly reduced ( P &lt; 0.01). A close correlation ( P &lt; 0.001) was found between the heat‐labile chemotactic activity in serum and the serum‐levels of lysozyme, suggesting the involvement of macrophages/monocytes in the asthmatic reaction and in the generation of the heat‐labile chemotactic activity found in serum after inhalation challenge.
Another plausible explanation for mist inhaler's toxicity
Authors: M. J. Seed, P. Cullinan, R. Agius
Journal: BMJ (2011)

In seeking an explanation for the apparent increase in all cause mortality associated with tiotropium delivered by the Respimat Soft Mist Inhaler compared with the Handihaler, Singh and colleagues focus on the possibility of increased cardiovascular deaths as a result of the higher peak plasma concentrations of tiotropium …