Relation between PAI-1 Gene Locus Polymorphism and Family History of Coronary Artery Disease
Authors: Maurizio Margaglione
Journal: Annals of Internal Medicine (1998)

Letters15 March 1998Relation between PAI-1 Gene Locus Polymorphism and Family History of Coronary Artery DiseaseMaurizio Margaglione, MD, Elvira Grandone, and Giovanni Di MinnoMaurizio Margaglione, MDOspedale Casa Sollievo della Sofferenza; San Giovanni Rotondo 71013 (FG), ItalyUniversita di Palermo; Palermo, ItalySearch for more papers by this author, Elvira GrandoneOspedale Casa Sollievo della Sofferenza; San Giovanni Rotondo 71013 (FG), ItalyUniversita di Palermo; Palermo, ItalySearch for more papers by this author, and Giovanni Di MinnoOspedale Casa Sollievo della Sofferenza; San Giovanni Rotondo 71013 (FG), ItalyUniversita di Palermo; Palermo, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In western countries, acute myocardial infarction and ischemic stroke are the most common causes of illness and death. Classic risk factors and lifestyle account only in part for the likelihood of ischemic events [1]. The familial aggregation of coronary heart disease is related largely to the clustering of cardiovascular risk factors. It is well recognized that a history of parental coronary heart disease is associated with increased risk for myocardial ischemia [2]. Low fibrinolytic activity is related to increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) and has been documented in persons who later develop myocardial infarction ...References1. Tuomiletho J, Kuulasmaa K. The WHO MONICA project. Assessing CHD mortality and morbidity. Int J Epidemiol. 1989; 18:S38-S45. Google Scholar2. Sing CF, Moll PP. Genetics of variability of CHD risk. Int J Epidemiol. 1989; 18(Suppl 1):S183-95. Google Scholar3. Hamsten A, De Faire U, Walldius G, Dahlen G, Szamosi A, Landou C, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet. 1987; 2:3-9. Google Scholar4. Dawson SJ, Wiman B, Hamsten A, Green F, Humphries S, Henney AM. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem. 1993; 268:10739-45. Google Scholar5. Margaglione M, Grandone E, Cappucci G, Colaizzo D, Giuliani N, Vecchione G, et al. An alternative method for PAI-1 promoter polymorphism (4G/5G) typing. Thromb Haemost. 1997; 77:605-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Maurizio Margaglione, MD; Elvira Grandone; Giovanni Di MinnoAffiliations: Ospedale Casa Sollievo della Sofferenza; San Giovanni Rotondo 71013 (FG), ItalyUniversita di Palermo; Palermo, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1998Volume 128, Issue 6Page: 508-509KeywordsAllelesCoronary heart diseaseIschemiaIschemic strokeMedical risk factorsMyocardial infarctionOdds ratioPolymerase chain reactionQuestionnairesStable coronary artery disease ePublished: 15 August 2000 Issue Published: 15 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...