Bronchogenic Carcinoma Associated with Severe Orthostatic Hypotension
Authors: JAN K. SIEMSEN
Journal: Annals of Internal Medicine (1963)

Case Studies1 April 1963Bronchogenic Carcinoma Associated with Severe Orthostatic HypotensionJAN K. SIEMSEN, M.D., LESTER MEISTER, M.D.JAN K. SIEMSEN, M.D., LESTER MEISTER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-669 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrthostatic hypotension may be idiopathic or secondary to various diseases of the nervous system (1-5), including diabetic neuropathy, (6) or to adrenocortical insufficiency, hypokalemia, renal amyloidosis (7), and porphyria (8). In spite of the recent interest in systemic manifestations of malignant tumors (9, 10), and particularly in the various forms of carcinomatous neuropathies (11-13), only one instance of orthostatic hypotension associated with carcinoma was found in the literature (14), and in that case renal sodium wastage and hyponatremia were a prominent part of the clinical picture.Although in the following case necropsy was unobtainable, a pathogenetic relationship between tumor and...References1. SCHIRGERHINESMOLNARTHOMAS AEAGDJE: Orthostatic hypotension. Proc. Mayo Clin. 36: 239, 1961. MedlineGoogle Scholar2. THOMASSCHIRGERLOVEHOFFMAN JEAJGDL: Orthostatic hypotension as the presenting symptom in craniopharyngioma. Neurology 11: 418, 1961. CrossrefMedlineGoogle Scholar3. SHARPEY-SCHAFER EP: Circulatory reflexes in chronic diseases of the afferent nervous system. J. Physiol. 134: 1, 1956. CrossrefMedlineGoogle Scholar4. SHYDRAGER GMGA: A neurological syndrome associated with orthostatic hypotension. Arch. Neurol. (Chicago) 2: 511, 1960. CrossrefMedlineGoogle Scholar5. FRIARTJEANTY JC: Zona associe a un syndrome de Guillain-Barre avec hypotension orthostatique. Acta Clin. Belg. 11: 365, 1956. CrossrefMedlineGoogle Scholar6. SHARPEY-SCHAFERTAYLOR EPPJ: Absent circulatory reflexes in diabetic neuritis. Lancet 1: 559, 1960. CrossrefMedlineGoogle Scholar7. WAGNER HN: Orthostatic hypotension. Bull. Hopkins Hosp. 105: 322, 1959. Google Scholar8. SCHIRGERMARTINGOLDSTEINHUIZENGA AWJNPKA: Orthostatic hypotension in association with acute exacerbations of porphyria. Proc. Mayo Clin. 37: 7, 1962. MedlineGoogle Scholar9. KNOWLESSMITH JHLH: Extrapulmonary manifestations of bronchogenic carcinoma. New Engl. J. Med. 262: 505, 1960. CrossrefMedlineGoogle Scholar10. BROWN CH: Systemic manifestations of carcinoma. Amer. Pract. 12: 639, 1961. Google Scholar11. DIAMOND MT: Carcinomatous neuropathy. Ann. Intern. Med. 54: 1259, 1961. LinkGoogle Scholar12. BRAINHENSON RRA: Neurological syndromes associated with carcinoma: carcinomatous neuropathy. Lancet 2: 971, 1958. CrossrefMedlineGoogle Scholar13. HENSONRUSSELLWILKINSON RADSM: Carcinomatous neuropathy and myopathy. Brain 77: 82, 1954. CrossrefMedlineGoogle Scholar14. IVY HK: Renal sodium loss and bronchogenic carcinoma. Arch. Intern. Med. (Chicago) 108: 47, 1961. CrossrefMedlineGoogle Scholar15. SOBELHENRY CRJ: Determination of catecholamines (adrenalin and nor-adrenalin) in urine and tissue. Amer. J. Clin. Path. 27: 240, 1957. CrossrefGoogle Scholar16. GITLOWORNSTEINMENDLOWITZKHASSISKRUK SELMSE: A simple colorimetric urine test for pheochromocytoma. Amer. J. Med. 28: 921, 1960. CrossrefMedlineGoogle Scholar17. ROTH GM: A clinical test for sweating. Proc. Mayo Clin. 10: 383, 1935. Google Scholar18. HICKLERTHOMPSONFOXHAMLIN RBGRLMJT: Successful treatment of orthostatic hypotension with 9-alpha-fluorohydrocortisone. New Engl. J. Med. 261: 788, 1959. CrossrefMedlineGoogle Scholar19. COHEN EI: L'hypotension des gastrectomises. Presse Med. 65: 688, 1957. MedlineGoogle Scholar20. EVELYNSINGHChapmanPERERATHALER KAMMWPGAH: Effect of thoracolumbar sympathectomy on the clinical course of primary (essential) hypertension. Amer. J. Med. 28: 188, 1960. CrossrefMedlineGoogle Scholar21. WANGMARSHALLSHEPHERD YRJJT: Effect of change in posture and of graded exercise on stroke volume in man. J. Clin. Invest. 39: 1051, 1960. CrossrefMedlineGoogle Scholar22. BICKELMANNLIPSCHUTZBRUNJES AGEJEF: Hemodynamics of idiopathic orthostatic hypotension. Amer. J. Med. 30: 26, 1961. CrossrefGoogle Scholar23. KROECKERWOOD EJEH: Comparison of simultaneously recorded central and peripheral arterial pressure pulses during rest, exercise and tilted position in man. Circ. Res. 3: 623, 1955. CrossrefMedlineGoogle Scholar24. SOLOMONKUHN ALA: Postural hypotension. Report of a case with hemodynamic studies of central, peripheral and pulmonary artery pressures. Amer. J. Med. 28: 328, 1960. CrossrefMedlineGoogle Scholar25. PAGEHICKAMSIECKERMCINTOSHPRYOR EBJBHOHDWW: Reflex venomotor activity in normal persons and in patients with postural hypotension. Circulation 11: 262, 1955. CrossrefMedlineGoogle Scholar26. GUYTON AC: The venous system and its role in the circulation. Mod. Conc. Cardiov. Dis. 27: 483, 1958. MedlineGoogle Scholar27. ZARRIELLO JJ: Idiopathic orthostatic hyposion and its relationship to positive "G"-tolerance. Armed Forces Med. J. 11: 535, 1960. MedlineGoogle Scholar28. Editorial. Orthostatic hypotension. Lancet 1: 635, 1960. Google Scholar29. BARNETTWAGNER AJGR: Severe orthostatic hypotension. Amer. Heart J. 56: 412, 1958. CrossrefMedlineGoogle Scholar30. JUSTIN-BESANCONLAMOTTE-BARILLONGRIVAUXTUTINHERNANDEZ LSMMJH: L'hypotension orthostatique, a propos d'un cas. Sem. Hop. Paris 37: 1415, 1961. MedlineGoogle Scholar31. SCHNEIDER PB: Orthostatic hypotension. Observations on the effect of levarterenol and Hypertensin II. Arch. Intern. Med. (Chicago) 110: 240, 1962. CrossrefMedlineGoogle Scholar32. GOLDENBERGPINESBALDWINGREENROH MKLEDDGCE: Hemodynamic responses of man to nor-epinephrine and epinephrine and its relation to the problem of hypertension. Amer. J. Med. 5: 792, 1946. CrossrefGoogle Scholar33. BOCKDENGLERKRECKEREICHEL KDHHJG: Untersuchungen ueber die Wirkung von Synthetischem Hypertensin II auf Elektrolythaushalt, Nierenfunktion und Kreislauf beim Menschen. Klin. Wschr. 36: 808, 1958. CrossrefMedlineGoogle Scholar34. KIPFER K: Postural hypotension: Ein Therapieversuch mit Synthetischem Hypertensin II. Cardiologia (Basel) 34: 131, 1959. CrossrefMedlineGoogle Scholar35. HICKLERHOSKINSHAMLIN RBRGJT: The clinical evaluation of faulty orthostatic mechanisms. Med. Clin. N. Amer. 44: 1237, 1960. CrossrefMedlineGoogle Scholar36. SUNDIN T: Influence of body posture on urinary excretion of adrenalin and nor-adrenalin. Acta Med. Scand. supp. 313: 1, 1959. Google Scholar37. LUFTVON EULER RUS: Two cases of postural hypotension showing a deficiency in release of nor-epinephrine and epinephrine. J. Clin. Invest. 32: 1065, 1953. CrossrefMedlineGoogle Scholar38. HICKLERWELLSTYLERHAMLIN RBREHTJT: Plasma catecholamine and EEG responses to acute postural changes. Amer. J. Med. 26: 410, 1959. CrossrefMedlineGoogle Scholar39. BENESTADNOE AMJ: Idiopathic orthostatic hypotension. Clinical and laboratory studies with report of a case. Acta Med. Scand. 150: 1, 1954. CrossrefMedlineGoogle Scholar40. HICKLERHAMLINWELLS RBJTRE: Plasma nor-epinephrine response to tilting in essential hypertension. Circulation 20: 422, 1959. CrossrefMedlineGoogle Scholar41. GOODALLMEEHAN MJP: Correlation of "G"-tolerance to urinary adrenaline and nor-adrenaline. Amer. J. Physiol. 187: 601, 1956. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Long Beach, CaliforniaFrom the Medical Service, Veterans Administration Hospital, Long Beach, California.Requests for reprints should be addressed to Jan K. Siemsen, M.D., Veterans Administration Hospital, 5901 East Seventh Street, Long Beach 4, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParaneoplastic NeuropathyAcquired NeuropathiesAutonome Störungen bei PolyneuropathienImmunological and endocrinological abnormalities in paraneoplastic disorders with involvement of the autonomic nervous systemNeurocardiogenic Syncope and Prinzmetal's Angina Associated With Bronchogenic CarcinomaOrthostatic hypotension and vasodilatory peptides in bronchial carcinoma.Secretion of atrial natriuretic peptide and vasopressin by small cell lung cancerParaneoplasia and Autoimmunologic Injury of the Nervous System: The Anti-Hu SyndromeParaneoplastic effects of pulmonary endocrine neoplasmsAspects étiologiques des hypotensions orthostatiquesParaneoplastic Encephalomyelitis and Subacute Dysautonomia due to an Occult Atypical Carcinoid Tumour of the LungThe Clinical Features of Non-Diabetic Autonomic FailureAutoimmune NeuropathiesOrthostatic Hypotension: Circulatory Dynamics and Clinical SpectrumAre cardiovascular reflexes more commonly impaired in patients with bronchial carcinoma?Autonomic dysfunction and Eaton Lambert syndromeAutonomic neuropathy and hypertrophic osteoarthropathy in association with malignancyAcute pandysautonomia and severe sensory deficit with poor recovery. A clinical, neurophysiological and pathological case study.Intestinal Pseudo-Obstruction as the Presenting Manifestation of Small-Cell Carcinoma of the Lung A Paraneoplastic Neuropathy of the Gastrointestinal TractMICHAEL D. SCHUFFLER, M.D., H. WALLACE BAIRD, M.D., C. RICHARD FLEMING, M.D., C. ELLIOTT BELL, M.D., THOMAS W. BOULDIN, M.D., JUAN R. MALAGELADA, M.D., DOUGLAS B. McGILL, M.D., SAMUEL M. LeBAUER, M.D., MURRAY ABRAMS, M.D., JAMES LOVE, M.D.Cancer, chemotherapy and anaesthesiaReversible Autonomic Neuropathy and Hypertrophic Osteoarthropathy in a Patient with Bronchogenic CarcinomaIdiopathic orthostatic hypotension: Circulating noradrenaline and ultrastructure of saphenous veinSevere orthostatic hypotension associated with carcinoma of the bronchus.Case reports and studies of paraneoplastic hypotension: Abnormal low pressure baroreceptor responsesBlood Pressure and Its RegulationPARANEOPLASTIC SYNDROMES OF NERVE, MUSCLE, AND NEUROMUSCULAR JUNCTIONLUNG TUMORS: HOW THEY PRODUCE THEIR SYNDROMESStudies in Clinical Shock and Hypotension 1 April 1963Volume 58, Issue 4Page: 669-676KeywordsExcretionHypotensionNervous systemNeuropathyNorepinephrinePathogensPorphyriaRenal diseasesSodiumTachycardia Issue Published: 1 April 1963 PDF downloadLoading ...