tbuckley/cabot-search huggingface dataset:
843. The Tupaia Paramyxovirus Envelope as Vector Delivery Module: Novel Fusion Protein Cleavage-Activation Sequence and Attachment Protein Retargeting
Authors: Christoph Springfeld, Veronika von Messling, Christian A. Tidona, Gholamreza Darai, Roberto Cattaneo
Journal: Molecular Therapy (2005)

Wild type MV infection occasionally induces lymphoma regression in humans, and recombinant viruses based on the vaccine MV strain are currently being developed as therapeutics for use in clinical trials for different types of cancer. Towards producing recombinant MV that target different tumor types we are operating at multiple levels: first, we have altered cell entry specificity by re-engineering the attachment protein (hemagglutinin, H) to bind to cancer-specific glycoproteins (J. Virol. 75:2087-96, 2001; J. Virol. 78, 302-13, 2004; Nat. Biotechnol. 22:331-6, 2004). Moreover, we have produced fusion (F) proteins that are selectively activated by matrix metalloproteases (Springfeld et al., this Abstract book), altered the viral host control evasion proteins (Devaux et al., this Abstract book; von Messling and Cattaneo, this Abstract book), and expressed suicide genes from an additional transcription unit (Mol. Ther. 9:S224, 2004). However a standing issue with the use of recombinant MV in human clinical trials is the frequent presence of neutralizing antibodies in human sera. Therefore, the possibility of exchanging the viral envelope with that of an animal virus that is not MV cross-reactive is being explored.
More on biphenotypic leukemias and the 5q‐syndrome
Authors: Alexander Haubenstock, Joseph H. Pipala, Ralph Zalusky
Journal: American Journal of Hematology (1985)

In their article "Chronic Anemia Progressing to Auer Rod-Positive and TdT-Positive Leukemia With 5q-Chromosomal Anomaly" Xavier and Kasimis [I] describe a unique patient with refractory anemia which evolved into a biphenotypic leukemia with 5q-as the sole chromosomal anomaly.At the time this case report was published we were treating a patient with acute leukemia and strikingly similar features.In 1982, a 78-year-old white woman developed a refractory, macrocytic anemia which required red blood cell transfusions twice a month.The platelet count was normal and the bone marrow showed an adequate number of nonlobulated megakaryocytes.In September 1984, the patient was admitted with a leukocyte count of 84.7001 mm3 with 39% blasts.The hemoglobin was 10.0 g/dl and the platelet count was 168.000/mm3.The bone marrow aspirate showed a homogeneous replacement of normal hematopoietic tissue with blasts and a diagnosis of acute leukemia was made.Thirty percent of the blast cells reacted positively with myeloperoxidase (MPO) and the periodic acid-Schiff reaction was positive in 10% of the blasts.Immunofluorescence staining for TdT was positive in 50% of the blast cells.A direct preparation of bone marrow specimen yielded 30 metaphase cells which all showed a partial deletion of the long arm of chromosome #5 (46,xx,5q-) as the sole anomaly.Furthermore, monoclonal antibody studies revealed the expression of monocytoid differentiation antigens on the leukemic cells (the respective antibodies MoU 26 and MoU 28 have been recently described in detail [2]).In contrast to Xavier and Kasimis's patient, we found MPO-positivity, as opposed to Auer rods, as proof for the myeloid differentiation of the leukemic cells, and the interstitital deletion of the long arm of chromosome #5 resulted in the loss of bands q14-q34 in our case as opposed to the q22-q33 breakage points in their patient.We agree with the authors that it is very unusual for a patient with the 5qsyndrome to evolve into an acute leukemia without developing additional chromosomal abnormalities.It is, however, not unusual for a preleukemic syndrome to evolve into a biphenotypic leukemia, and the entity of TdT-positive leukemia with monocytoid features has now been widely confirmed to represent approximately 10 % of acute leukemias [2,3].We finally agree that the fact that all cells-in both Xavier and Kasimis's case and in our patient-revealed the 5q-anomaly strongly suggests a monoclonal origin of these biphenotypic leukemias [4].
Immunization with ARA h1,2,3-Lamp-Vax Peanut Vaccine Blocked IgE Mediated-Anaphylaxis in a Peanut Allergic Murine Model
Authors: Xiu-Min Li, Ying Song, Yan Su, Teri Heiland, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2015)
Longitudinal study of the effect of apolipoprotein e4 allele on the association between education and cognitive decline in elderly men
Authors: S. Kalmijn, E. J M Feskens, L. J Launer, D. Kromhout
Journal: BMJ (1997)

Objective: To investigate if the incidence of disorders of spermatogenesis and testicular tissue morphology have changed in middle aged Finnish men over 10 years.Design: Two necropsy series completed in 1981 and in 1991.
Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation
Authors: Jean Sévigny, Christian Sundberg, Norbert Braun, Olaf Guckelberger, Eva Csizmadia, Imrana Qawi, Masato Imai, Herbert Zimmermann, Simon C. Robson
Journal: Blood (2002)
Clinical Performance Measures and Medical Malpractice—Reply
Authors: Aaron S. Kesselheim, David M. Studdert
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Samter's Immunologic Diseases, vols 1 &amp;amp; 2
Authors: Roberto Kretschmer
Journal: JAMA (1995)

Although in the midst of a complex process of defining itself as an independent subspeciality, clinical immunology has been vigorously alive and well all these years, and the identification of many a fundamental immunological phenomenon came first from shrewd clinical observations. Small surprise then that a classic like<i>Samter's Immunologic Diseases</i>is back on the bookshelves, now in its 5th edition (following editions in 1965, 1971, 1978, and 1988). Further evidence of the sustained vigor of bedside immunology is the recent appearance of Samter's curiously contrapuntal (1963, 1968, 1975, 1982, and 1993) British counterpart,<i>Clinical Aspects of Immunology</i>, edited by P. J. Lachmann et al (Blackwell, 1993), also in its 5th edition, as well as at least two newcomers:<i>Clinical Immunology</i>, edited by Robert R. Rich et al (Mosby, 1995), and the inaugural number of the<i>Year Book of Allergy and Clinical Immunology</i>(Mosby, 1994), edited by a seasoned team
The Uncertainties Surrounding Carotid Endarterectomy
Authors: Henry J. M. Barnett
Journal: JAMA (1992)

The year 1991 must rank as a vintage year for all physicians who care for patients at risk of ischemic stroke. Three of the most prestigious medical journals with the widest circulation published the results of multicenter trials that determined an unequivocal benefit of carotid endarterectomy for patients experiencing symptoms due to severe carotid artery disease.<sup>1-3</sup> In these trials, surgery was compared with medical therapy: patients with recent focal symptoms in the brain or retina supplied by a stenosed carotid artery were randomly assigned to receive the best contemporary medical care alone or the same treatment with surgery added. Patients were not eligible if they had evidence of serious heart disease, other organ failure, or malignancy. One study was stopped after 3 years for patients with 70% stenosis or greater (defined as "severe") because of a clear difference in stroke-free survival between the medical and surgical groups.<sup>1</sup>Patients
Acute Airway Responses to Hair-Spray Preparations
Authors: Eugenija Zuskin, Arend Bouhuys
Journal: New England Journal of Medicine (1974)

Acute exposures (20 seconds) to hair-spray preparations A, B and C caused significant decreases of maximum expiratory flow rates at low lung volumes in healthy men and women. Peak expiratory flow rates were reduced slightly after hair spray A only. The decreases were more pronounced on partial than on maximal expiratory flow-volume curves. On the partial curves, flow at mid-vital capacity decreased on the average 22 per cent immediately after exposure to spray A (16 subjects), 21 per cent after spray B (16 subjects), 29 per cent after spray C (nine subjects) and 4 per cent after placebo spray. These changes suggest that hair sprays cause acute, reversible narrowing of small airways. The chemical nature of the active ingredient (or ingredients) in hair sprays is not known; their mode of action may involve histamine release from lung tissue or a direct effect on airway smooth muscle, or both. Controlled inhalation studies in man should be required as part of the toxicologic evaluation of consumer products that may pose inhalation hazards. (N Engl J Med 290:660–663, 1974)
Prurigo nodularis in a peritoneal dialysis patient
Authors: Eun Hui Bae, Bo Mi Park, Yong Un Kang, Joon Seok Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim
Journal: Kidney International (2013)

A 43-year-old man presented to our hospital with generalized skin papulonodular and pruriginous eruptions. Clinical examination revealed grouped and scattered pruritic papules and nodules on his legs, arms, and trunk (Figure 1). The patient had type 2 diabetes mellitus and hypertension, with no history of allergy or dermatitis. The papules first appeared on the lower legs when the patient began treatment with peritoneal dialysis, 2 years earlier. The papules gradually disseminated to the legs, arms, back, and chest. We performed a skin biopsy, and the biopsy findings indicated pseudo-epitheliomatous acanthosis, hyperkeratosis, and vascular hyperplasia of the upper dermis with mild inflammatory perivascular infiltration—symptoms that are characteristic of prurigo nodularis (Supplementary Figure S1 online). Prurigo nodularis is an unusual disorder of unknown etiology that could result from the accumulation of an unidentified pruritogenic, poorly dialyzable uremic substance in hemodialysis patients.1.Morton C.A. Henderson I.S. Jones M.C. et al.Acquired perforating dermatosis in a British dialysis population.Br J Dermatol. 1996; 135: 671-677Crossref PubMed Scopus (114) Google Scholar No data are available on this condition in peritoneal dialysis patients. Therefore, nephrologists should consider prurigo nodularis when this skin lesion is observed. It is notoriously resistant to therapy,2.Accioly-Filho J.W. Nogueira A. Ramos-e-Silva M. Prurigo nodularis of Hyde: an update.J Eur Acad. 2000; 14: 75-82Crossref PubMed Scopus (49) Google Scholar and is characterized by extremely pruritic nodules with well-defined clinical symptoms and histopathological findings. The patient was treated with a gradually tapered 16-mg dose of oral methylprednisolone, oral antibiotics, oral antihistamines, and cryotherapy. This treatment led to a temporary amelioration in the clinical symptoms, which later recurred. The patient has been on the wait list for a kidney transplantation, which is known to be the most effective treatment for uremic pruritus–associated prurigo nodularis. Download .jpg (.37 MB) Help with files Supplementary Figure Figure S1. Skin biopsy findings. Supplementary material is linked to the online version of the paper at http://www.nature.com/ki Download .doc (.05 MB) Help with doc files Supplementary Figure Legent
Long-term Care Training, Research Expanding
Authors: Phil Gunby
Journal: JAMA (1993)

THERE ARE about 150 fellowship and residency training programs—in existence or anticipated—in geriatric medicine in the United States and Canada. In one way or another, virtually all will have an impact on long-term care. That total of 150 is the estimate of the American Geriatrics Society, New York, NY, which is gathering data now. These data will be published in a sixth edition of the society's<i>Directory of Fellowship Programs in Geriatric Medicine</i>within the next 6 months. While the estimated total is only slightly larger than the 145 programs reported in the fifth edition of the directory (September 1990), the society notes that some programs are suspended, temporarily or permanently, when there are difficulties in recruiting. At the same time, new programs appear. While training programs for physicians and medical students continue to evolve, many of the United States' 140 allopathic and osteopathic medical schools are conducting research into
Diet and Coronary Heart Disease: Another View
Authors: Charles J. Glueck, Fred Mattson, Edwin L. Bierman
Journal: New England Journal of Medicine (1978)

Note: The article on "Diet-Heart: End of an era," by Dr. George Mann, which we published in the issue of September 22, 1977, produced much correspondence (see the issues of January 12 and 19, 1978) and several offers to write detailed rebuttals. We do not encourage rebuttal articles, but considering the importance of the subject, we agreed to allow the Nutrition Committee of the American Heart Association to prepare the following analysis. We think it is a balanced and well-documented statement that merits careful attention — particularly its final admonition that "a reasoned resolution of the controversy is not currently . . .
Employment in ankylosing spondylitis.
Authors: L E McGuigan, H H Hart, P J Gow, B L Kidd, R R Grigor, T E Moore
Journal: Annals of the Rheumatic Diseases (1984)

All patients with ankylosing spondylitis attending our rheumatology clinics were reviewed to assess the effect of their disease on employment. Back movement was measured in three planes, chest expansion determined, and peripheral joint involvement was noted to see whether these correlated with work capability. Sixty patients were reviewed (47 men, 13 women; mean disease duration 24.3 years). Nine were unemployed, but only four of these attributed this condition to ankylosing spondylitis. Although all four had severe neck, back, and hip involvement, this did not differentiate them from other patients who were fully employed. There was no relationship between disease duration and employment. The prospect for continued employment in ankylosing spondylitis is good even when the disease is long standing and severe.
Sustained Delivery Fluocinolone Acetonide Vitreous Implants
Authors: José Cunha-Vaz, Paul Ashton, Raymond Iezzi, Peter Campochiaro, Pravin U. Dugel, Frank G. Holz, Michel Weber, Ronald P. Danis, Baruch D. Kuppermann, Clare Bailey, Kathleen Billman, Barry Kapik, Frances Kane, Ken Green
Journal: Ophthalmology (2014)

To present the safety and efficacy of intravitreal implants releasing 0.2 μg/day fluocinolone acetonide (FAc) in patients with chronic versus nonchronic diabetic macular edema (DME). To assess ocular characteristics, anatomic changes, and re-treatment and ancillary therapies that may explain the differential treatment effect seen with intravitreal implants releasing FAc 0.2 μg/day in patients with chronic and nonchronic DME. An overall benefit-to-risk assessment for the FAc 0.2-μg/day and FAc 0.5-μg/day doses has been reported previously. Preplanned subgroup analysis of chronic (duration of diagnosis, ≥3 years) and nonchronic (duration of diagnosis, <3 years) DME in patients from 2 randomized, sham injection-controlled, double-masked, multicenter clinical trials. Patients with persistent DME despite 1 or more macular laser treatment were randomized 1:2:2 to sham injection (n = 185), FAc 0.2 μg/day (n = 375), or FAc 0.5 μg/day (n = 393). Patients received study drug or sham injection and after 6 weeks were eligible for rescue laser. Based on re-treatment criteria, additional masked study drug could be given after 1 year. Percentage of patients with improvement of 15 letters or more from baseline. Secondary outcomes included other parameters of visual function and foveal thickness. At month 36, the difference between FAc 0.2 μg/day and sham control in the percentage of patients who gained 15 letters or more was significantly greater in chronic DME patients (FAc 0.2 μg/day, 34.0% vs. sham, 13.4%; P<0.001), compared with patients with nonchronic DME (FAc 0.2 μg/day, 22.3% vs. sham, 27.8%; P = 0.275). The greater response in patients with chronic DME was not associated with baseline ocular characteristics, changes in anatomic features, or differences in re-treatment or ancillary therapies. The ocular adverse event profile for FAc 0.2 μg/day was similar regardless of DME duration. This is the first published analysis correlating duration of diagnosis of DME with treatment effect. In patients with chronic DME, FAc 0.2 μg/day provides substantial visual benefit for up to 3 years and would provide an option for patients who do not respond to other therapy.
Chemical Weapons on the Home Front
Authors: Alan L. Pearlman
Journal: New England Journal of Medicine (1969)

Despite wide publicity in the press and in law-enforcement magazines, the report by Penneys, Israel and Indgin, in this issue of the Journal, represents the first study of Chemical Mace to appear in the scientific literature. Penneys et al. studied four cases of allergic contact dermatitis, two resulting from police use of Chemical Mace, and two acquired accidentally during laboratory evaluation of the product. They demonstrated that the sensitizing agent was the tear-gas component, 1-chloroacetophenone (CN), and not the solvent-carrier mixture. It is important to note that contact sensitivity developed in five of the eight volunteers who were exposed only . . .
Childhood HIV is in danger of becoming a neglected disease, say experts
Authors: A. Gulland
Journal: BMJ (2012)

The success in reducing the number of children born with HIV is in danger of leaving children who already have the disease with poor access to treatment, experts in HIV and AIDS have warned.

Denis Broun, executive director of Unitaid, a not for profit organisation that purchases drugs for the treatment of HIV and AIDS and other diseases, has welcomed news that the number of new infections in children is falling. But he said that because fewer children are born with the virus, drug companies would no longer have an incentive to manufacture treatments and that childhood HIV might become a neglected disease.

A report by UNAIDS, the joint United Nations programme on HIV and AIDS, released a week before world AIDS day on 1 December, said that the …
WHA adopts new International Health Regulations
Authors: Claudia Orellana
Journal: The Lancet Infectious Diseases (2005)

New International Health Regulations (IHRs) setting out how to respond to international health threats were approved by the World Health Assembly on May 23. Deficiencies in the current regulations were exposed during epidemics of severe acute respiratory syndrome (SARS) and ebolavirus. The encroaching spectre of a new influenza pandemic hastened the agreement, following a decade of deliberation. The IHRs establish structures and procedures for prompt notification of critical events to the WHO, who would then be responsible for declaring emergencies, recommending measures including any quarantine and travel restrictions, and coordinating an international response.
Novel approach for enhancing atrioventricular nodal conduction delay mediated by endogenous adenosine.
Authors: C Kollias-Baker, J Xu, A Pelleg, L Belardinelli
Journal: Circulation Research (1994)

The 2-amino-3-benzoylthiophene derivative PD 81,723 potentiates the A1 receptor-mediated negative dromotropic effect of exogenous adenosine and adenosine receptor agonists in guinea pig isolated perfused and in situ hearts. The objective of this study was to determine whether PD 81,723 could amplify the cardiac actions of endogenous adenosine. Two approaches known to increase the myocardial interstitial concentration of adenosine--hypoxia, which increases the production of adenosine and the inhibition of adenosine kinase, which decreases its metabolism--were used to test this hypothesis. In guinea pig hearts in situ, PD 81,723 (2 mg/kg i.v.) potentiated the atrioventricular (AV) nodal conduction delay caused by hypoxemia (PaO2, 14 to 19 mm Hg). In guinea pig isolated hearts, PD 81,723 (5 mumol/L) increased by twofold the stimulus-to-His bundle (S-H) interval prolongations induced by both a 5-minute period of hypoxia (25% O2/70% N2/5% CO2) and the administration of the adenosine kinase inhibitor iodotubercidin (40 to 70 nmol/L) but had no effect on coronary conductance. Hypoxia and hypoxia plus PD 81,723 (5 mumol/L) caused equivalent increases in the concentration of adenosine in epicardial transudate, from 0.13 +/- 0.15 to 0.48 +/- 0.1 and 0.45 +/- 0.4 mumol/L, respectively. Similar to the allosteric enhancer, the nucleoside uptake blocker draflazine (0.1 mumol/L) also increased by twofold the S-H interval prolongation caused by hypoxia. In contrast to the allosteric enhancer, draflazine increased the concentration of adenosine in epicardial transudate during hypoxia from 0.48 +/- 0.15 to 1.5 +/- 0.4 mumol/L. Draflazine also increased coronary conductance by approximately twofold in guinea pig normoxic constant-fold perfused hearts.(ABSTRACT TRUNCATED AT 250 WORDS)