tbuckley/cabot-search huggingface dataset:
Ear wax removal: a survey of current practice.
Authors: J F Sharp, J A Wilson, L Ross, R M Barr-Hamilton
Journal: BMJ (1990)

OBJECTIVE--To determine the methods of removing ear wax used by local general practitioners and the incidence of associated complications. DESIGN--Postal survey of 312 general practitioners serving a population of about 650,000; supplementary study of ear, nose, and throat outpatients to quantify the improvement in aural acuity after wax removal. SETTING--Catchment area of the Edinburgh otolaryngological unit. PARTICIPANTS--289 General practitioners who responded to the survey; 21 outpatients in the ear, nose, and throat department with occlusive wax. RESULTS--274 General practitioners removed wax by syringing, but only 53 (19%) always performed the procedure themselves; the remainder routinely delegated the task to practice nurses, some of whom had received no instruction. Ears were rarely examined again after the procedure. Complications had been experienced by 105 practitioners (38%) and included perforation, canal lacerations, and failure of wax removal. The removal of occlusive wax improved hearing by a mean of 5 dB over the frequencies analysed. CONCLUSIONS--About 44,000 ears are syringed each year in the area and complications requiring specialist referral are estimated to occur in 1/1000 ears syringed. The incidence of complications could be reduced by a greater awareness of the potential hazards, increased instruction of personnel, and more careful selection of patients.
Quantification of pollen solute release using pollen grain column chromatography
Authors: J. N. Baraniuk, M. Bolick, R. Esch, C. E. Buckley
Journal: Allergy (1992)

The impact of pollen on the respiratory mucosa was modeled by studying the process by which solutes are eluted from pollen grains. Rye grass ( Loliuin perenne ), short ragweed ( Ambrosia artemisiifolia ), and white oak ( Quercus alba ) pollens were packed between glass wool plugs in small columns. Water was pumped through the columns and the eluate solute yield was determined by measurement of the dry solute weight. Solute separation was rapid, and concentrations and osmolalities of the eluate decreased exponentially. Theoretical initial solute concentrations were 179 g/1 for rye grass, 55 g/1 for short ragweed and 349 g/1 for oak pollen eluates. Theoretical initial osmolarities of the same eluates were 321 mOsm/kg for rye grass, 196 mOsm/kg for ragweed and 424 mOsm/kg for oak pollen. Sequential separation of allergens ( Lol p I, Amb a I, Ainb a V ), enzymes and proteins was demonstrated by specific assays. These observations suggest that the complex stimulus produced immediately after pollen grain hydration at the respiratory mucosal fluid interface is much more intense than previously envisioned. Sequential separation of pollen components has important implications for the production of improved allergenic extracts.
Protection from Digitalis Toxicity with the Prophylactic Use of Diphenylhydantoin Sodium An Arrhythmic-Inotropic Dissociation
Authors: RICHARD H. HELFANT, BENJAMIN J. SCHERLAG, ANTHONY N. DAMATO
Journal: Circulation (1967)

Diphenylhydantoin sodium (Dilantin) given prophylactically increased the dose of digitalis necessary to produce toxicity by 72 to 224%. At constant heart rates, pretreatment with diphenylhydantoin sodium did not alter the elevation of rate of rise of left ventricular pressure produced by the glycoside. Two implications have been drawn from these findings. First, the inotropic and arrhythmic actions of digitalis can be dissociated, since diphenylhydantoin sodium seems specifically to counteract the electrophysiological actions of the glycoside. Second, pretreatment with diphenylhydantoin sodium significantly widened the "toxic-therapeutic" ratio of digitalis. This, therefore, may have important clinical applications.
Calcitriol and Renal Function
Authors: Claus Christiansen
Journal: JAMA (1981)

<h3>To the Editor.—</h3> In a recent COMMENTARY Massry and Goldstein (1979;242:1875) questioned two recent controlled investigations<sup>1,2</sup>from our departments that demonstrated deterioration of renal function during treatment with 1α-hydroxylated vitamin D compounds: 1α-OH D<sub>3</sub>and 1,25(OH)<sub>2</sub>D<sub>3</sub>in patients with advanced chronic renal failure. Massry and Goldstein cite their experience with 1,25(OH)<sub>2</sub>D<sub>3</sub>treatment of three patients with moderate renal failure (creatinine clearance, 32, 49, and 52 mL/min).<sup>3</sup>According to the authors, creatinine clearance remained stable in all three patients during treatment with 1,25(OH)<sub>2</sub>D<sub>3</sub>. From these sparse observations the authors come to the far-reaching conclusion that 1,25(OH)<sub>2</sub>D<sub>3</sub>is a useful prophylactic agent to prevent the progression of bone disease as renal failure advances. In our opinion there exist no data to show this, and certainly not those of Massry and Goldstein. Furthermore, these data are irrelevant
Comparison of Six Commercial Techniques in the Measurement of Microalbuminuria in Diabetic Patients
Authors: Sau Cheung Tiu, Shui Shan Lee, Mei Wan Cheng
Journal: Diabetes Care (1993)

To evaluate the advantages and drawbacks of six commercially available techniques in the measurement of microalbuminuria in diabetic patients.Timed overnight urine samples from 75 patients in our diabetic clinic were tested with 2 qualitative tests (Micral-Test and Microbumintest) and assayed with 4 quantitative tests, which used different methodologies: double-antibody RIA, RID, IT, and NEPH. All tests were commercially available. The double-antibody RIA was taken as the golden standard. All urine samples were either negative or trace by Albustix (Ames, Elkhart, IN). Interobserver variation for the 2 qualitative tests was assessed by asking 12 experienced nurses to read the color changes on the dipsticks and the tablets simultaneously, using test solutions with albumin concentrations of 16, 32, and 64 mg/L.The 75 urine samples contained 0-154.2 mg/L of albumin. Correlation coefficients of RID, NEPH, and IT with RIA were 0.970, 0.975, and 0.974, respectively. Intra-assay and interassay CVs ranged from 1.36-11.5%. Microbumintest had a higher sensitivity (100 vs. 75%), but lower specificity (82.5 vs. 87.3%) than Micral-Test. Considerable interobserver variation existed in the matching of colors for both tests. Discrepancies were especially significant with Microbumintest, with 8 of 12 nurses misreading the 32 mg/L level.Correlations of the 3 quantitative methods with RIA were all > 0.970. Choice of test may depend more on considerations such as time, space, number of specimens to be handled, and availability of instruments. Both qualitative tests showed a relatively low specificity. Positive tests must be confirmed with quantitative assays before microalbuminuria is diagnosed. Microbumintest had a higher sensitivity, but its unacceptably high interobserver variation and lower specificity were serious drawbacks.
Treating Hepatitis C in “Difficult-to-Treat” Patients
Authors: Jean-Michel Pawlotsky
Journal: New England Journal of Medicine (2004)

The current standard treatment for chronic hepatitis C is the combination of pegylated interferon alfa and ribavirin, a synthetic guanosine analogue. In the pegylated form of interferon, the interferon alfa molecule is linked to a polyethylene glycol molecule to ensure sustained interferon concentrations after single weekly injections. Pegylated interferon alfa potently inhibits the replication of hepatitis C virus (HCV) and has immunomodulatory properties that probably accelerate the clearance of infected cells. Ribavirin exerts a weak and transient early antiviral effect and acts primarily by preventing relapses during and after therapy in patients who have had an initial response. Ribavirin's mechanisms . . .
A case of mycosis fungoides (cutaneous T cell lymphoma) with cold agglutinins
Authors: J. Berth-Jones, J. Holmes, R. Marks
Journal: British Journal of Dermatology (1988)

Journal Article A case of mycosis fungoides (cutaneous T cell lymphoma) with cold agglutinins Get access J. Berth‐Jones, J. Berth‐Jones Department of Medicine (Dermatology), University Hospital of Wales, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. Holmes, J. Holmes Haematology, University Hospital of Wales, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. Marks R. Marks Department of Medicine (Dermatology), University Hospital of Wales, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 6, 1 June 1988, Pages 854–855, https://doi.org/10.1111/j.1365-2133.1988.tb02606.x Published: 01 June 1988
Methods for epidemiological study of injury and illness in great britain olympic sport: the injury/illness performance project (IIPP)
Authors: D Palmer-Green, G Hunter, R Jaques, C Fuller, C Price
Journal: British Journal of Sports Medicine (2011)

Background Prevention of injury and illness in elite sport can have not only athlete health benefits but also potential positive performance gains. As the first step towards prevention, valid injury/illness surveillance data is needed. Objective Develop and implement a valid and sensitive multisport surveillance model for elite sport in Great Britain, to identify incidence, severity, nature, and risk factors for injury/illness in both individual and team sports. Design A longitudinal prospective surveillance study, with definitions for injury/illness, time loss and restriction severity, and implementation practices, was developed by the research group, and methodology framework modified from recent injury surveillance consensus statements to be applicable for individual and team sports. Setting National training centres for elite sport in Great Britain, including domestic and international competition venues. Participants National team lottery funded athletes from identified sport national governing bodies. Interventions Report forms recording all athlete injuries/illnesses causing complete time loss or restricted participation in competition or training are completed by medical support staff, and competition and training exposure by coaching support staff. Data collection commenced pre season 2009/2010 and is ongoing. Main outcome measure Sport specific injury incidence and illness prevalence, time loss and restriction severity, and risk factors for the most common and severe injuries/illnesses. Results 14 Olympic sports are involved in the surveillance study. Sport specific results reports on injury incidence, illness prevalence, and associated risk factors are being produced, with targeted sport specific recommendations for prevention strategies. Conclusion The injury/illness performance project provides objective information to medical and coaching support staff, and elite sports are starting to implement prevention interventions for key risk factors. The long term aim is to reduce the number and severity athlete injuries/illnesses, the detrimental effects of time loss and restriction in competition and training, and ultimately through this enhance athlete performance.
TCT-121 Thoracic Aortic Pseudoaneurysm Following Endovascular Stent Graft Placement for Treatment of Type B Dissection: What causes it?
Authors: Rolf Alexander Janosi, Markus Bettin, Thomas Konorza, Holger Eggebrecht, Raimund Erbel
Journal: Journal of the American College of Cardiology (2012)
Abstract A37: Efficacy of combining a novel Aurora kinase inhibitor with radiotherapy in orthotopic liver tumor model of hepatocellular carcinoma
Authors: Jason Chia-Hsien Cheng, Zhong-Zhe Lin, Chou Chia-Hung, Ann-Lii Cheng
Journal: Clinical Cancer Research (2010)

Abstract Radiotherapy is one of the treatment options for hepatocellular carcinoma (HCC), but the unsatisfactory results are mainly due to insufficient dose to the tumor from hepatic intolerance. As compared to advanced technology of radiotherapy, the experience in the combined use of the effective molecular target and radiotherapy remains limited. This study was aimed to assess the effect of combining a novel Aurora kinase inhibitor, VE465, with radiotherapy, by testing the in vitro and in vivo models of human HCC. Human HCC cell line Huh-7, was treated with combined irradiation and the low- toxic dose of VE465. A significant effect on enhancing the radiation induced cell death was found in clonogenic assay. VE-465 induced proliferation blockade, histone H3 (Ser10) dephosphorylation, mitotic disturbance, and apoptosis in Huh-7 cells. The in vivo efficacy of combining VE465 with radiotherapy was investigated in the ectopic xenograft subcutaneous tumor and orthotopic liver tumor models of severe combined immunodeficient mice. Pretreatment with daily i.p. administration of VE465 (20 mg/kg) significantly enhanced the therapeutic effect of radiotherapy (5 Gy per day for 5 days) on Huh-7 derived ectopic xenograft tumor model by 54%. This differential tumor suppression correlated with the modulation of intratumoral biomarker stainings associated with histone 3 phosphorylation inhibition and apoptosis regulation. Furthermore, VE465 improved intrahepatic tumor control and survival of radiotherapy (4 Gy per day for 5 days) treated Huh-7 derived orthotopic liver tumor model by 17.2%, reduction in tumor size. The synergistic effect of combining VE465 with radiotherapy in HCC was associated with histone3 phosphorylation inhibition and cell cycle regulation. We conclude that VE465 is a potent inhibitor of Aurora kinase with clinical value in therapeutic strategies for radiotherapy to HCC. Citation Information: Clin Cancer Res 2010;16(14 Suppl):A37.
Effect of predigested fat on intestinal stimulation of plasma cholecystokinin and gall bladder motility in coeliac disease.
Authors: W P Hopman, G Rosenbusch, M P Hectors, J B Jansen
Journal: Gut (1995)

Cholecystokinin (CCK) release and gall bladder emptying in response to a fatty meal are completely abolished in coeliac disease. To determine the effect of lipid digestion on CCK release and gall bladder motility, six patients with untreated coeliac disease and a flat jejunal mucosa were studied on two separate days. After an overnight fast, the plasma CCK concentration and gall bladder volume were measured before and at regular intervals after the intraduodenal instillation of 60 ml corn oil (triglycerides) incubated with 40 ml saline or with 40 ml bile and pancreatic juice. The mean (SEM) concentration of free fatty acids in the aqueous phase of corn oil after incubation with bile and pancreatic juice (predigested corn oil) was 78 (35) mM compared with 0.1 (0.1) mM in the aqueous phase of corn oil incubated with saline (undigested corn oil). Integrated plasma CCK in response to predigested corn oil was significantly greater than that in response to undigested corn oil (101 (18) pM. 80 min v-2 (9) pM.80 min; p &lt; 0.005). Similarly, integrated gall bladder contraction in response to predigested corn oil was significantly larger than that after undigested corn oil (817 (210) ml. 80 min v-225 (243) ml. 80 min; p &lt; 0.05). In contrast to undigested corn oil, corn oil that has been predigested with bile and pancreatic juice induces plasma CCK secretion and gall bladder contraction in patients with untreated coeliac disease, presumably by generating and rendering soluble lipolytic products.
Pulmonary Alveolar Proteinosis Revealing a Telomerase Disease
Authors: Sylvain Marchand-Adam, Bruno Diot, Pascal Magro, Anne De Muret, Christophe Guignabert, Caroline Kannengiesser, Arturo Londono-Vallejo, Irena Draskovic, Annick Toutain, Patrice Diot
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Marchand-Adam, Sylvain Diot, Bruno Magro, Pascal De Muret, Anne Guignabert, Christophe Kannengiesser, Caroline Londono-Vallejo, Arturo Draskovic, Irena Toutain, Annick Diot, Patrice United States Am J Respir Crit Care Med. 2013 Aug 1;188(3):402-4. doi: 10.1164/rccm.201301-0010LE.
Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line.
Authors: Y Wang, R Roman, T Schlenker, Y A Hannun, J Raymond, J G Fitz
Journal: Journal of Clinical Investigation (1997)

Cholangiocytes represent an important target of injury during the ischemia and metabolic stress that accompanies liver preservation. Since K+ efflux serves to minimize injury during ATP depletion in certain other cell types, the purpose of these studies was to evaluate the effects of ATP depletion on plasma membrane K+ permeability of Mz-ChA-1 cells, a model human biliary cell line. Cells were exposed to dinitrophenol (50 microM) and 2-deoxyglucose (10 mM) as the standard model of metabolic injury. Whole-cell and single K+ channel currents were measured using patch clamp techniques; and intracellular [Ca2+] ([Ca2+]i) was estimated by calcium green-1 fluorescence. Metabolic stress increased [Ca2+]i, and stimulated translocation of the alpha isoform of protein kinase C (PKCalpha) from cytosolic to particulate cell fractions. The same maneuver increased membrane K+ permeability 40-70-fold as detected by (a) activation of K+selective whole cell currents of 2,176+/-218 pA (n = 34), and (b) opening of apamin-sensitive K+ channels with a unitary conductance of 17.0+/-0.2 pS. PKCalpha translocation and channel opening appear to be related since stress-induced K+ efflux is inhibited by chelation of cytosolic Ca2+, exposure to the PKC inhibitor chelerythrine (25 microM) and downregulation of PKC by phorbol esters. Moreover, K+ currents were activated by intracellular perfusion with recombinant PKCalpha in the absence of metabolic inhibitors. These findings indicate that in biliary cells apamin-sensitive K+ channels are functionally coupled to cell metabolism and suggest that cytosolic Ca2+ and PKCalpha are selectively involved in the response.
Management of ductal carcinoma in situ
Authors: S. Hetelekidis, S. J. Schnitt, M. Morrow, J. R. Harris
Journal: CA A Cancer Journal for Clinicians (1995)

The increased use of screening mammography in the past two decades has led to a marked increase in the number of patients diagnosed with ductal carcinoma in situ. Treatment has traditionally involved mastectomy, but this approach has come under increasing scrutiny, and the treatment of ductal carcinoma in situ has become one the most controversial areas in the field of breast disease. This article reviews current concepts regarding the diagnosis, natural history, and treatment of ductal carcinoma in situ.
Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis
Authors: Sylvia Kamphuis, Wietse Kuis, Wilco de Jager, Gijs Teklenburg, Margherita Massa, Grace Gordon, Marjolein Boerhof, Ger T Rijkers, Cuno S Uiterwaal, Henny G Otten, Alessandro Sette, Salvatore Albani, Berent J Prakken
Journal: The Lancet (2005)
Cimetidine for duodenal ulceration in patients undergoing haemodialysis.
Authors: C C Doherty, F A O'Connor, K D Buchanan, M G McGeown
Journal: BMJ (1977)

Peptic ulcer is a common problem in advanced renal failure, but most drugs for ulcers are hazardous in this condition. In a small open study cimetidine was given to nine patients with acid hypersecretion and endoscopically diagnosed duodenal ulceration who were undergoing haemodialysis. The patients obtained good pain relief and suffered no serious side effects. Both basal and stimulated acid output fell considerably and the plasma gastrin response to food increased during treatment. Two patients with recurrent vomiting during haemodialysis had a striking response to cimetidine, which suggested that such vomiting may be acid-mediated in some patients. These preliminary results suggest that cimetidine may prove to be an advance in the management of peptic ulcer in uraemic patients.
Low-Dose Arsenic: In Search of a Risk Threshold
Authors: Charles W. Schmidt
Journal: Environmental Health Perspectives (2014)

cientists long ago linked high levels of arsenic in groundwater to cancer and other environmental illnesses, particularly in Taiwan, Bangladesh, and South America, where the contamination can often reach extraordinarily high levels of 1,000 ppb or more.Now concerns are shifting to the health effects of much lower doses such as those that many Americans live with every day.
Synergistic activity of the proteasome inhibitor PS-341 with non-myeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma
Authors: Apollina Goel, Angela Dispenzieri, Susan M. Geyer, Suzanne Greiner, Kah-Whye Peng, Stephen J. Russell
Journal: Blood (2006)
THE RELATIONSHIP OF LUPUS ERYTHEMATOSUS AND ERYTHEMA MULTIFORME, WITH AN ILLUSTRATIVE CASE
Authors: JAMES GALLOWAY, J. M. H. MACLEOD
Journal: British Journal of Dermatology (1908)

Journal Article THE RELATIONSHIP OF LUPUS ERYTHEMATOSUS AND ERYTHEMA MULTIFORME, WITH AN ILLUSTRATIVE CASE Get access JAMES GALLOWAY, JAMES GALLOWAY Search for other works by this author on: Oxford Academic Google Scholar J. M. H. MACLEOD J. M. H. MACLEOD Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 20, Issue 3, 1 March 1908, Pages 65–78, https://doi.org/10.1111/j.1365-2133.1908.tb16551.x Published: 01 March 1908
NEUTRON ACTIVATION ANALYSIS OF TRACE ELEMENTS IN SKIN V. COPPER AND ZINC IN PSORIASIS
Authors: MOHAMED M. MOLOKHIA, BENJAMIN PORTNOY
Journal: British Journal of Dermatology (1970)

Journal Article NEUTRON ACTIVATION ANALYSIS OF TRACE ELEMENTS IN SKIN V. COPPER AND ZINC IN PSORIASIS Get access MOHAMED M. MOLOKHIA, MOHAMED M. MOLOKHIA Manchester and Salford Hospital for Skin Diseases, Quay Street, Manchester MS 3HL Search for other works by this author on: Oxford Academic Google Scholar BENJAMIN PORTNOY BENJAMIN PORTNOY Manchester and Salford Hospital for Skin Diseases, Quay Street, Manchester MS 3HL Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 3, 1 September 1970, Pages 376–381, https://doi.org/10.1111/j.1365-2133.1970.tb15720.x Published: 01 September 1970 Article history Accepted: 07 May 1970 Published: 01 September 1970
Meta-analyses: sources of bias
Authors: P. Sedgwick
Journal: BMJ (2011)

<h3>Abstract</h3> Biological aging of human organ systems reflects the interplay of age, chronic disease, lifestyle and genetic risk. Using longitudinal organ imaging and physiological phenotypes from the UK Biobank, we establish normative models of biological age for 7 body (cardiovascular, pulmonary, musculoskeletal, immune, renal, hepatic and metabolic) and 3 brain (gray matter, white matter and brain connectivity) systems. We find that an organ’s biological age selectively influences the aging of other organ systems, revealing a multiorgan aging network. Brain age is most strongly influenced by the biological age of the cardiovascular, pulmonary and metabolic systems, whereas the musculoskeletal system is an in-degree hub of the aging network. We report organ age profiles for 16 chronic diseases, where advanced biological aging extends from the organ of primary disease to multiple systems. Advanced body age associates with several lifestyle and environmental factors, leucocyte telomere lengths and mortality risk, and predicts survival time (AUC=0.77) and premature death (AUC=0.86). Our work reveals the multisystem nature of human aging. It may enable early identification of individuals at increased risk of aging-related morbidity and inform new strategies to potentially limit organ-specific biological aging in such individuals.
Nu Sigma Nu Convention—Amended Date of Meeting.
Authors: John L. Irwin
Journal: JAMA (1895)

Detroit,Mich., April 12, 1895. <h3>To the Editor:</h3> —In my letter to you of March 7, having inclosed a notice of the Nu Sigma Nu Medical Convention for theJournal'slast issue, I gave the dates of meeting in Minneapolis as May 13,14 and 15. The date has since been changed by Grand Council to June 3, 4 and 5, 1895. So<i>please make the correction</i>, and oblige. Very truly yours,