tbuckley/cabot-search huggingface dataset:
THE SURGICAL TREATMENT OF VARICOSE VEINS OF THE FEMALE PELVIS
Authors: LUDWIG A. EMGE
Journal: JAMA (1925)

The last few years has witnessed an ever widening interest in the disturbances in the venous circulation of the female generative organs. Controversies relative to pathology, symptomatology, diagnosis and treatment are as lively today as they were in 1889, when Dudley1presented his views on the subject before the New York Obstetrical Society. Since 1890 the subject has appeared periodically in the literature without materially changing the basic facts set forth by Dudley.  In regard to treatment, the general opinion still favors destructive surgery. In a preliminary report on clinical and private material, I2have pointed out that drastic methods can, in the vast majority, be replaced by constructive surgery. Further experience with this method both in private practice and in the service of the Woman's Clinic of the Stanford School of Medicine convinces me still more firmly of the feasibility of this method. Figures in this present
Toxic Doses of Acetaminophen Suppress Hepatic Glutathione Synthesis in Rats
Authors: Bernhard H. Lauterburg, Jerry R. Mitchell
Journal: Hepatology (1982)

The effect of a toxic dose of acetaminophen on hepatic glutathione turnover was studied in fed and fasted rats. Following the administration of 1 gm per kg of acetaminophen, the fractional rate of glutathione turnover increased from 0.19 to 0.28 hr-1 in fed rats and from 0.43 to 0.50 hr-1 in rats fasted for 48 hr. The increase in the fractional rate of turnover was proportionally much less than the decrease in hepatic glutathione concentration resulting from the toxic dose of acetaminophen. Thus, the estimated hepatic synthesis of glutathione decreased from 0.86 and 1.50 mumole per gm liver . hr to 0.59 and 0.53 mumole per gm . hr in fed and fasted rats, respectively. The excretion of acetaminophen-sulphate was significantly decreased in fasted rats. The fraction of administered acetaminophen metabolized to the mercapturic acid, however, was similar in both groups. Nevertheless, all fasted animals had massive centrilobular necrosis whereas virtually no necrosis was observed in fed animals. The administration of sulfate did not protect against liver injury in fasted rats. In view of the similar synthesis of glutathione in fed and fasted rats following a toxic dose of acetaminophen, an inability to synthesize adequate quantities of glutathione or a decreased availability of sulfate cannot account for the increased susceptibility to liver injury in the fasted state. However, a toxic dose of acetaminophen depletes the hepatic glutathione to a lower nadir before glutathione is repleted by synthesis, and a greater amount of tissue arylation occurs during this brief period of critically depleted glutathione.
Association of primary renal non-Hodgkin's lymphoma with mesangioproliferative glomerulonephritis
Authors: Johannes Zahner, Claus-Dieter Gerharz, Dieter Bach, Andreas Heer-Sonderhoff, Martin Winkelmann, Bernd Grabensee, Wolfgang Schneider
Journal: American Journal of Hematology (1996)

A 27-year-old male developed nonoliguric renal failure. Renal biopsy of the left kidney showed infiltration by a diffuse large-cell non-Hodgkin's lymphoma (NHL). Laparoscopy, CT scans of the abdomen and thorax, and bone-marrow biopsy revealed no further manifestations of lymphoma. Primary renal NHL was diagnosed. The patient attained complete remission with cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) chemotherapy and remained disease-free for 13 years. Eight years after his first presentation, the patient developed acute oliguric renal failure with nephrotic syndrome. Mesangioproliferative glomerulonephritis was diagnosed in a biopsy of the left kidney. Chronic hemodialysis was required until cadaver kidney transplantation was successfully performed 5 years later. Although the association of NHL and glumerulonephritis has been described several times before, to our knowledge this is the first report of glomerulonephritis in primary renal lymphoma. © 1996 Wiley-Liss, Inc.
Oral Contraceptives and Breast Cancer
Authors: Wylie Burke
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
It's 'North to Alaska' for Research on Some Vaccines by Infectious Diseases Staff
Authors: Paul Cotton
Journal: JAMA (1990)

ABSTRACT NATIVE ALASKANS are important allies to CDC epidemiologists.High rates of hepatitis B and Haemophilus influenzae infection plague the Inuit (commonly called Eskimo), Aleut and Indian populations, providing unique opportunities for focused study.The Center for Infectious Diseases keeps 14 full-time employees at its Arctic Investigations Program field station in Anchorage.The effective use of hepatitis B vaccine was first demonstrated here, despite the tremendous distances and logistic problems inherent in studying a population spread over 200 different communities, some as far as 500 frozen miles (800 km) from major medical centers, says director Ann Lanier, MD, MPH. Since only 15% of Alaska is accessible by road, researchers had to fly in and out of villages to collect blood samples, perform laboratory screens for exposure, administer vaccine, and then retest for immunogenicity.Now 7 years out, the study is continuing to follow up patients to see when a booster shot
Dislocation of the Lenses
Authors: Sameer K Mathur, Daniel Grodinsky
Journal: New England Journal of Medicine (2004)

Daniel Grodinsky, M.D. Hines Veterans Affairs Hospital Hines, IL 60141 60-year-old man with a history of frequent falls presented after a fall that resulted in minor trauma to the head. A review of systems was remarkable only for the recent onset of intermittent blurry vision, which the patient blamed for his current fall. A computed tomographic (CT) scan of the head that had been obtained three months earlier was available (Panel A). Another CT scan of the head was obtained on presentation and showed bilateral lens dislocations (Panel B, arrows). The lens dislocations were presumably due to repeated trauma and to weakened zonular attachment of the lens. The weakened zonular attachment was probably due to the pseudoexfoliation syndrome.
Response to Letter Regarding Article “Improved Neurological Outcome With Continuous Chest Compressions Compared With 30:2 Compressions-to-Ventilations Cardiopulmonary Resuscitation in a Realistic Swine Model of Out-of-Hospital Cardiac Arrest”
Authors: Gordon A. Ewy, Ronald W. Hilwig, Arthur B. Sanders, Robert A. Berg, Charles W. Otto, Melinda M. Hayes, Karl B. Kern, Mathias Zuercher
Journal: Circulation (2008)
BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life.
Authors: P D Hart, I Sutherland
Journal: BMJ (1977)

The Medical Research Council9s trial of BCG and vole bacillus vaccines in the prevention of tuberculosis in Great Britain has ended after 20 years9 follow-up of the 54 239 participants, who were aged 14 to 15 years when the entered the trial in 1950-2. Participants who were tuberculin positive on entry were left unvaccinated; those who were tuberculin negative were allocated at random to an unvaccinated or to a vaccinated group. The protective efficacy of each of the two vaccines, among those initially tuberculin negative, was 84% during the first five years, and gradually decreased, averaging 77% for each vaccine over the whole period. The incidence of tuberculosis decreased substantially in all groups during the trial, however, and of the total of 610 cases of tuberculosis only 27 developed between 15 and 20 years. Thus we cannot make a reliable assessment of efficacy during this final period. The prevalence and incidence of tuberculosis in Great Britain have decreased radically since this trial began. The expected benefit from large-scale BCG-vaccination of children is now far less, and may decrease further if the incidence of tuberculosis continues to decline.
The Revised Uniform Requirements of the Vancouver Group
Authors: Elizabeth Knoll
Journal: JAMA (1988)

Announcements of new journals arrive on physicians' desks every week, if not every day, along with all the existing journals that still clamor to be read. It has been estimated, for instance, that the ratio of faculty positions in internal medicine to internal medicine journals is about 15 to 1,<sup>1</sup>suggesting to the innocent mind that more people publish in some journals than read them. The cataloging creativity of librarians and the memory of readers are ever more tested by the proliferation of medical journals. So is the patience of authors, since every journal has its own editorial style, spelled out in small print in Instructions for Authors or in a formal style manual. The fact that articles that are published in medical journals frequently acknowledge the contributions of secretaries as well as those of professional colleagues is a reminder of the sheer technical effort involved in getting a
Constrictive pericarditis complicating dermatomyositis.
Authors: R Tamir, A J Pick, E Theodor
Journal: Annals of the Rheumatic Diseases (1988)

Chronic constrictive pericarditis may complicate both rheumatoid arthritis and systemic lupus erythematosus. To our knowledge, however, this is the first time it has been described in a patient with dermatomyositis. This association should be kept in mind as constrictive pericarditis should be considered in the differential diagnosis of liver cirrhosis and Budd-Chiari syndrome in rheumatic diseases.
THE ROLE OF DIFFERENT TYPES OF ATRIAL FIBRILLATION ON APPROPRIATE AND INAPPROPRIATE DEVICE THERAPY AND SURVIVAL IN IMPLANTABLE CARDIOVERTER DEFIBRILLATOR PATIENTS
Authors: Johannes B. Van Rees, C. Jan Willem Borleffs, Guido H. Welsenes, Enno T. van der Velde, Lieselot van Erven, Jeroen J. Bax, Martin J. Schalij
Journal: Journal of the American College of Cardiology (2010)
Alcoholism and Traffic Deaths
Authors: Julian A. Waller, Henry W. Turkel
Journal: New England Journal of Medicine (1966)

RECENT reports have suggested that a substantial proportion of traffic accidents involving alcohol may be attributable to people with a drinking problem rather than to social drinkers. This argument finds support in 7 types of studies:Comparison of blood alcohol levels of people involved in traffic accidents and of people not so involved. Among the drinkers in both groups the levels reached by the accident group are much higher than those of the nonaccident group and suggest an ingestion pattern that, at best, is at the extreme end of the social drinking scale.15 Comparison of admissions to alcoholism rehabilitation programs . . .
Still Life With Yellow Roses
Authors: Janet M. Torpy
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Teicoplanin-loaded borate bioactive glass implants for treating chronic bone infection in a rabbit tibia osteomyelitis model
Authors: Xin Zhang, WeiTao Jia, YiFei Gu, Wei Xiao, Xin Liu, DePing Wang, ChangQing Zhang, WenHai Huang, Mohamed N. Rahaman, Delbert E. Day, Nai Zhou
Journal: Biomaterials (2010)
Abstract 2123: Cytoplasmic STAT1 expression level opposes disease-specific survival of sarcoma patients
Authors: Mary A. Zimmerman, Kebin Liu, Dina C. Lev
Journal: Cancer Research (2011)

Abstract Signal Transducer and Activator of Transcription 1 (STAT1) is a key mediator in the interferon gamma (IFN-γ) signaling pathway. It is well known that IFN-γ-activated STAT1 (pSTAT1) plays a critical role in the suppression of tumor development. However, STAT1 has also been shown to act as a tumor promoter in certain types of cancers. These findings indicate that STAT1 harbors dual functionality, functioning as either a tumor suppressor, or a promoter, a distinction that may ultimately depend on the tumor microenvironment. In this study, we hypothesized that the distribution of STAT1 (cytoplasmic vs nuclear) could affect disease-specific survival of sarcoma patients. STAT1 protein expression levels were examined in 123 soft tissue sarcoma samples from human patients by immunohistochemical staining. We observed a positive correlation between the nuclear STAT1 (pSTAT1) protein level and disease-specific survival. A statistically significant inverse correlation was also observed between the cytoplasmic STAT1 protein level and disease-specific survival in sarcoma patients. We have shown that STAT1 is negatively regulated by an interferon-stimulated gene, Interferon Regulatory Factor 8 (IRF8). Disruption of IRF8 function by ectopic expression of an IRF8 dominant negative mutant resulted in dramatic up-regulation of STAT1, down-regulation of Janus kinase 1 (JAK1) and pSTAT1, and increased metastatic potential of sarcoma cells in an experimental metastasis mouse model. In addition, using microRNA microarray analysis we have identified a possible mechanism for these changes through mi106b. The possibility of cytoplasmic STAT1 and nuclear STAT1 accumulation being responsible for the observed difference in disease-specific survival of sarcoma patients merits further study of the role STAT1's localization plays in cancer progression. Direct evidence of cytoplasmic STAT1 increasing tumor cell survival, as well as confirmation of our proposed mechanism for STAT1 regulation through IRF8 is still needed. Taken together, our research suggests that IRF8 is a negative regulator of cytoplasmic STAT1 and STAT1 is indeed a tumor promoter. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2123. doi:10.1158/1538-7445.AM2011-2123
Parathyroid Carcinoma: A Review of 62 Patients*
Authors: ELIZABETH SHANE, JOHN P. BILEZIKIAN
Journal: Endocrine Reviews (1982)

CARCINOMA of the parathyroid gland is a rare cause of primary hyperparathyroidism, accounting for approximately 3–4% of patients with hypercalcemia and elevated parathyroid hormone levels (1, 2). In 1969, Holmes et al. (3) reviewed the data on 46 patients with parathyroid carcinoma published since the original description of the disease in 1938. The subjects of that report had, in general, marked and symptomatic hypercalcemia as well as the frequent presence of both skeletal and renal complications of hyperparathyroidism. These observations suggested that malignant parathyroid disease usually presented somewhat differently than the much more common benign form of primary hyperparathyroidism. Since the report of Holmes et al. (3) there have been additional clinical descriptions of parathyroid carcinoma but no further comprehensive reviews in English. Over this same period of time, surveys of benign primary hyperparathyroidism have documented a rather dramatic change in its incidence and clinical presentation (4–9). Has the clinical profile of parathyroid carcinoma also changed? This question, as well as our involvement in the care of five patients with parathyroid carcinoma, has prompted us to review the more recent history of this tumor.
Intrapleural streptokinase for pleural infection
Authors: Demosthenes Bouros, Katerina M Antoniou, Richard W Light
Journal: BMJ (2006)

A step forward in managing pleural effusions? 

P arapneumonic pleural effusions and pleural empyema are clinically challenging conditions, both therapeutically and diagnostically, because of their heterogeneity.1 They range from small, uncomplicated, pleural effusions that do not require specific treatment to multiloculated effusions and empyema with pleural fibrosis, trapped lung, systemic sepsis, respiratory failure, and metastatic infection.12 Drainage of pleural pus has always been regarded as the key to successful management,1–3 but newer techniques are now also available to clinicians: image guided small bore catheter insertion, intrapleural instillation of fibrinolytics, and medical thoracoscopy. In the face of these newer approaches several management algorithms and guidelines have been published,13 but there are still many unanswered questions about diagnosis and treatment. One of the most important concerns the use of fibrinolytics.

Until recently five small randomised controlled trials of intrapleural fibrinolytics had been reported.4–8 A double blind trial comparing streptokinase 250 000 IU and urokinase 100 000 IU in 50 patients has shown that both these fibrinolytic agents are equally effective, but …
Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus–prone B6.Sle1.Yaa animals
Authors: Kenichiro Maeda, Alex Malykhin, Brittany N. Teague-Weber, Xiao-Hong Sun, A. Darise Farris, K. Mark Coggeshall
Journal: Blood (2009)
Claude E. Welch, MD
Authors: Francis D. Moore
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dendrite Self-Avoidance Requires Cell-Autonomous Slit/Robo Signaling in Cerebellar Purkinje Cells
Authors: Daniel A. Gibson, Stephen Tymanskyj, Rachel C. Yuan, Haiwen C. Leung, Julie L. Lefebvre, Joshua R. Sanes, Alain Chédotal, Le Ma
Journal: Neuron (2014)
The Independent Contributions of Diabetic Neuropathy and Yasculopatny in Foot Ulceration: How great are the risks?
Authors: Marguerite J McNeely, Edward J Boyko, Jessie H Ahroni, Victoria L Stensel, Gayle E Reiber, Douglas G Smith, Roger E Pecoraro
Journal: Diabetes Care (1995)

OBJECTIVE To describe the relative contributions of neurological and vascular abnormalities to the overall risk of diabetic foot ulceration. RESEARCH DESIGN AND METHODS A case-control study of diabetic veterans from the Seattle Veterans Affairs Medical Center was conducted using data collected from 46 patients with diabetic foot ulcers and 322 control subjects. Neuropathy was determined by vibratory, monofilament, and tendon reflex testing. Macro-vascular disease was measured by ankle-arm blood pressure index, and cutaneous perfusion was measured by transcutaneous oxygen tension (TcPO2) on the dorsal foot. A multi variate logistic regression model was used to adjust for confounding variables and to calculate the odds ratios (ORs) for each independent risk factor. RESULTS Three variables were significant independent predictors of foot ulceration: absence of Achilles tendon reflexes (adjusted OR 6.48, 95% confidence interval [CI] 2.37–18.06), insensate to the 5.07 monofilament (adjusted OR 18.42, 95% CI 3.83–88.47), and TcPO2 &amp;lt;30 mmHg (adjusted OR 57.87, 95% CI 5.08–658.96). Absent vibratory sensation and low ankle-arm blood pressure index were not significant independent risk factors. CONCLUSIONS Both neuropathy and vasculopathy are strong independent risk factors for the development of diabetic foot ulcers. In our model, the strongest risk factor is impaired cutaneous oxygenation. However, in the clinical setting, sensory examination with a 5.07 monofilament probably remains the single most practical measure of risk assessment.
Headliners: Allergies: Ragweed Subpollen Particles Reach Deep into Lungs
Authors: Jerry Phelps
Journal: Environmental Health Perspectives (2007)

A physician who conducted some of the first studies documenting the effect of lead poisoning on children.An epidemiologist studying the effects of exposure to diethylstilbestrol (DES).A toxicologist pointing out the many different chemical exposures associated with impulsivity.Though each of their disciplines uses a different language, all of these scientists study the links between the environment and childhood disease.They are just a few of the researchers who converged at the "Children's Environmental Health Research: Past, Present, and Future" conference held 22-23 January 2007 at the NIEHS.Sponsored in full by the NIEHS and planned jointly with the EPA, the conference aimed to get scientists talking about what types of research have been most effective.The result was recommendations to help chart the course for NIEHS children's environmental health research over the next five to ten years, including the future of the Centers for Children's Environmental Health and Disease Prevention Research.