tbuckley/cabot-search huggingface dataset:
Prognostic Indicators for Blood and Marrow Transplant Patients Admitted to an Intensive Care Unit
Authors: KRISTEN J. PRICE, PETER F. THALL, SUSANNAH K. KISH, VICKIE R. SHANNON, BORJE S. ANDERSSON
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Although hematopoietic stem cell transplantation (HSCT) can be curative in patients with certain malignancies, survival is poor if the recipient becomes critically ill. This prospective study examined the outcomes of 115 consecutive HSCT patients admitted to the medical intensive care unit (MICU) of a tertiary cancer center and identified variables associated with survival. The need for endotracheal intubation and mechanical ventilation ("intubation") had a profound adverse effect on survival. Overall, 9 of 48 (18.8%) intubated patients survived compared with a survival rate of 44 of 67 (65.7%) among patients not intubated (p < 0.001). This pattern persisted for nearly all patient subgroups. Among intubated patients, those receiving peripheral blood stem cell transplant (PBSCT) had significantly better survival than bone marrow transplant (BMT) patients (8 of 26, 31% versus 1 of 22, 4%; p = 0.028). Multiple logistic regression analyses indicated that the probability a patient admitted to the MICU survived decreased significantly if the patient was intubated, had an allogeneic rather than autologous transplant, had an infection or gastrointestinal bleeding, and also decreased with higher respiratory rate, higher heart rate, longer time from transplant to MICU admission or higher bilirubin. These results may be of value in deciding which critically ill patients will benefit from intubation following major complications after HSCT transplantation.
Effects of R-PIA, a selective A1 adenosine agonist, on haemodynamics and ischaemic arrhythmias in pigs
Authors: C L Wainwright, J R Parratt
Journal: Cardiovascular Research (1993)

Adenosine has previously been shown to protect against ischaemia induced ventricular arrhythmias. The aim of this study was to determine whether stimulation of A1 adenosine receptors with a selective agonist also protects against arrhythmias, and to attempt to elucidate the underlying mechanisms.Large White/Welsh Landrace cross breed domestic pigs (25-40 kg) subjected to left anterior descending coronary artery occlusion were used. R-PIA [R(-)N6-(2-phenylisopropyl) adenosine; 5 micrograms.kg-1] was given prior to coronary artery occlusion and the effects on haemodynamic variables and early ischaemic arrhythmias in the absence and presence of right atrial pacing were studied. The three experimental groups were: solvent controls, n = 10; R-PIA without pacing, n = 10; R-PIA with atrial pacing, n = 10. Ex vivo assessment of platelet aggregation was also performed to determine any inhibitory effects of R-PIA on platelets.Administration of R-PIA without atrial pacing reduced the total number of ventricular ectopic beats induced by coronary occlusion, from 326(SEM 71) in controls to 121(30) (p < 0.05) and the incidence of ventricular fibrillation from 70% to 20% (p < 0.05). At the dose used, R-PIA reduced heart rate from 102(7) to 74(3) beats.min-1, with a consequent reduction in mean arterial blood pressure from 95(4) to 81(3) mm Hg. Atrial pacing following drug administration, at a rate of 109(5) beats.min-1, restored blood pressure and abolished the antiarrhythmic effects of R-PIA. Drug intervention had no effect on either ex-vivo platelet aggregation or coronary sinus oxygen content, suggesting a lack of activity at A2 adenosine receptors.An A1 adenosine receptor agonist exerts a marked protection against ischaemia induced ventricular arrhythmias and fibrillation in pigs. The reversal of this effect by restoring heart rate suggests that the drug induced bradycardia may be important in the antiarrhythmic action of R-PIA, possibly via an anti-ischaemic effect.
Coagulation and Fibrinolytic Systems in Pre-eclampsia and Eclampsia
Authors: J. Bonnar, G. P. McNicol, A. S. Douglas
Journal: BMJ (1971)

The coagulation and fibrinolytic mechanisms were investigated in a group of patients with severe pre-eclampsia and eclampsia and the findings were compared with those of healthy women in late pregnancy. In patients with pre-eclampsia the following significant differences were found: (1) greater depression of plasma fibrinolytic activity (euglobulin lysis time) than in normal pregnancy, (2) a higher level of inhibitor to urokinaseinduced lysis, (3) increased levels of serum fibrin degradation products, and (4) reduced platelet counts.In patients with eclampsia a progressive increase of the level of serum fibrin degradation products was found over the three days following eclamptic seizures. No such increase occurred after grand mal seizures in late pregnancy. The findings in this study support the view that intravascular clotting is taking place in pre-eclampsia and that this disturbance of the balance between coagulation and fibrinolysis may be localized to certain areas of the vascular compartment, particularly the placental and renal circulations. Fibrin deposition in the maternal vessels supplying the placenta would impair the placental blood flow, which may explain the placental insufficiency which occurs in pre-eclampsia. Likewise fibrin deposition in the renal vasculature will result in glomerular damage and proteinuria. Hypertension may be related to the renal ischaemic changes or a compensatory response to the presence of fibrin deposition in the vascular compartment. This evidence of intravascular fibrin deposition raises the question of the possible therapeutic value of antithrombotic agents to inhibit the clotting process. On a theoretical basis such treatment might be expected to improve blood flow to the placenta and thereby fetal growth.
16,16-dimethyl prostaglandin E2 delays collagen formation in nutritional injury in rat liver
Authors: Mary J. Ruwart, Bob D. Rush, Karen F. Snyder, Ken M. Peters, Henry D. Appelman, Keith S. Henley
Journal: Hepatology (1988)

Chronic nutritional injury was induced in rats by a high-fat, lipotrope-deficient diet. The hepatoprotective effect of 16,16-dimethyl prostaglandin E 2 on the deposition of collagen and fat was assessed by histological evaluation and measurement of hydroxyproline. Dose-response studies established that optimal protection was achieved by the twice daily administration of 16,16-dimethyl prostaglandin E 2 at 100 μg per kg (subcutaneous) or 250 μg per kg (oral). 16,16-Dimethyl prostaglandin E 2 and a crystalline analog [( p -acetami-dobenzamido)phenyl ester of 16,16-dimethyl prostaglandin E 2 significantly delayed both the deposition of collagen and the increase in hepatic hydroxyproline content. There was an excellent correlation between the histological assessment of collagen and the biochemical measurement of hydroxyproline. These data provide a rationale for the evaluation of prostaglandins in the treatment of human liver disease.
Drug‐induced linear IgA disease with antibodies to collagen VII
Authors: None Wakelin, None Allen, None Zhou, None Wojnarowska
Journal: British Journal of Dermatology (1998)

Linear IgA disease (LAD) is characterized by circulating and tissue‐bound IgA antibodies against heterogeneous antigens in the cutaneous basement membrane zone. In most cases the cause is unknown, but a minority of cases has been drug induced. We report a 76‐year‐old man who developed an acute blistering eruption following high‐dose penicillin treatment for pneumococcal septicaemia. Indirect immunofluorescence demonstrated dermal binding IgA antibodies, and Western blotting of serum showed reactivity with a 250 kDa dermal antigen corresponding to collagen VII of anchoring fibrils. Indirect immunoelectron microscopy showed antibody labelling in the lamina densa and sublamina densa zone. This is one of the few cases of drug‐induced LAD in which the target antigen profile has been characterized, and the first in which the antigen has been shown to correspond to collagen VII.
QRS-T Patterns in Multiple Precordial Leads that May Be Mistaken for Myocardial Infarction
Authors: GORDON B. MYERS
Journal: Circulation (1950)

The electrocardiograms of patients with pathologic evidence of right ventricular hypertrophy and/or dilatation and exclusion of myocardial infarction are presented to bring out certain features likely to be mistaken for myocardial infarction: (1) abnormal qR or QS patterns or cove plane inversion of the T waves in leads from the right precordium; (2) reduction in the amplitude of the initial R wave or replacement by a QS deflection and/or change from an upright to an inverted T wave as the electrode is moved from the V 1 position to the transitional zone; (3) abnormal qrS deflections in leads from the left axilla.
A Nucleolar Protein ApLLP Induces ApC/EBP Expression Required for Long-Term Synaptic Facilitation in Aplysia Neurons
Authors: Hyoung Kim, Sue-Hyun Lee, Jin-Hee Han, Jin-A Lee, Ye-Hwang Cheang, Deok-Jin Chang, Yong-Seok Lee, Bong-Kiun Kaang
Journal: Neuron (2006)
On the role of coenzyme Q10 in cardiovascular diseases
Authors: Pawan K Singal, Neelam Khaper, Vince Palace, Dinender Kumar
Journal: Cardiovascular Research (1999)

Judging from the response, Dr Bliznakov appears to have completely missed the point of our article published in the section on ‘Cardiovascular Conundra Series’ [1]. Our paper discusses only concepts as well as provides a glimpse of the evolution of our knowledge-base on the significance of oxidative stress in heart disease, since the time of the first discovery of oxygen. The paper was never meant to offer a detailed discussion of any individual, favourite antioxidant. We all know that a current list of potential antioxidants can run into several pages and it keeps growing everyday. Thus, any attempt to mention all antioxidants in any significant way will be a futile exercise.

In Dr Bliznakov’s commentary, it is alleged that we have not provided enough clinical data on the use of antioxidants in different heart disease conditions. For the past 20 years, our laboratory has focussed …
Restoring Trust between Patient and Doctor
Authors: G T Johnson
Journal: New England Journal of Medicine (1990)

For almost 15 years, I have been straddling the fence between the medical profession and the public that consumes its services. My position as a onetime practicing physician and a current communicator to medical consumers has over the years drawn letters and comments from each side complaining about the other. However, I have sensed recently that each side recognizes more and more that continuing criticism will only make matters worse and that in a quite literal sense, neither side can afford to live without the other. Without good doctors to care for us, we medical consumers could pay a terrible, . . .
A Behavioral Approach to Marital Therapy
Authors: Evangelos C. Dimitriou
Journal: Psychotherapy and Psychosomatics (1983)

In this paper we refer to some problems encountered and techniques used in treating 14 couples with behavioral psychotherapy. In all 14 cases neurotic symptomatology was present, at least in the spouse who first sought help. Patients also complained of a lack of between-couple communication and understanding. 12 spouses complained of an unsatisfactory sex life. Treatment was planned in coordination with the couple and tasks were set for both of them. The main target was the improvement of communication in every aspect of marital life. Treatment lasted for about 3-6 months, and every couple had about 8-12 sessions. The outcome was considered as excellent in 4 couples and satisfactory in 7. In 3 cases no improvement was observed. A year later no recurrence was reported.
The New Era of Prospective Payment for Hospitals
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1982)

The federal government, facing massive budget deficits and the expectation that Medicare costs will double to $110 billion by 1987 if there are no changes in present trends, has approved another round of sweeping policies to curtail this growth and, for the first time, to begin the process of reordering the economic incentives that have driven the program since its creation. As a consequence of these changes, arrived at with strong bipartisan support and industry acquiescence, hospitals, skilled nursing homes, and (inevitably) physicians will be placed at greater financial risk for their medical actions.Congress adopted the measures as part . . .
Master Techniques in Orthopaedic Surgery: Relevant Surgical Exposures
Authors: Michael A. Terry
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia
Authors: Vijay P. S. Rawat, Silvia Thoene, Vegi M. Naidu, Natalia Arseni, Bernhard Heilmeier, Klaus Metzeler, Konstantin Petropoulos, Aniruddha Deshpande, Leticia Quintanilla-Martinez, Stefan K. Bohlander, Karsten Spiekermann, Wolfgang Hiddemann, Michaela Feuring-Buske, Christian Buske
Journal: Blood (2007)
Chorea in Affections of the Heart: Bleeding in Apoplexy
Authors: R. Chambers
Journal: BMJ (1846)

THIR HEART.but local depletion quickly counteracts it.In tb*, case, oa the third day after admision, there was dulnes in the cardiac region, and the heart's sounds were described as muffled.There was no palpitation, no emlbarrassment in the breathing, no pain in that region.I did not wait for such symptoms to develope themselves, we might then have been too late to avert the mischief.A large blister was applied all over that side of the chest, and a qnarter of a grain of tartar emetic, one grain of calomel, and half a grain of opium were ordered every four hours.These were continued
Multitarget Therapy for Induction Treatment of Lupus Nephritis
Authors: Zhihong Liu, Haitao Zhang, Zhangsuo Liu, Changying Xing, Ping Fu, Zhaohui Ni, Jianghua Chen, Hongli Lin, Fuyou Liu, Yongcheng He, Yani He, Lining Miao, Nan Chen, Ying Li, Yong Gu, Wei Shi, Weixin Hu, Zhengzhao Liu, Hao Bao, Caihong Zeng, Minlin Zhou
Journal: Annals of Internal Medicine (2014)

Treatment of lupus nephritis (LN) remains challenging.To assess the efficacy and safety of a multitarget therapy consisting of tacrolimus, mycophenolate mofetil, and steroid compared with intravenous cyclophosphamide and steroid as induction therapy for LN.24-week randomized, open-label, multicenter study. (ClinicalTrials.gov: NCT00876616).26 renal centers in China.Adults (aged 18 to 65 years) with biopsy-proven LN.Tacrolimus, 4 mg/d, and mycophenolate mofetil, 1.0 g/d, versus intravenous cyclophosphamide with a starting dose of 0.75 (adjusted to 0.5 to 1.0) g/m2 of body surface area every 4 weeks for 6 months. Both groups received 3 days of pulse methylprednisolone followed by a tapering course of oral prednisone therapy.The primary end point was complete remission at 24 weeks. Secondary end points included overall response (complete and partial remission), time to overall response, and adverse events.After 24 weeks of therapy, more patients in the multitarget group (45.9%) than in the intravenous cyclophosphamide group (25.6%) showed complete remission (difference, 20.3 percentage points [95% CI, 10.0 to 30.6 percentage points]; P < 0.001). The overall response incidence was higher in the multitarget group than in the intravenous cyclophosphamide group (83.5% vs. 63.0%; difference, 20.4 percentage points [CI, 10.3 to 30.6 percentage points]; P < 0.001), and the median time to overall response was shorter in the multitarget group (difference, -4.1 weeks [CI, -7.9 to -2.1 weeks]). Incidence of adverse events did not differ between the multitarget and intravenous cyclophosphamide groups (50.3% [91 of 181] vs. 52.5% [95 of 181]).The study was limited to 24 weeks of follow-up.Multitarget therapy provides superior efficacy compared with intravenous cyclophosphamide as induction therapy for LN.National Basic Research Program of China, National Key Technology R&D Program.
Preoperative angiographic diagnosis of primary sarcoma of the pulmonary artery.
Authors: J K Hynes, H C Smith, D R Holmes, W D Edwards, T C Evans, T A Orszulak
Journal: Circulation (1982)

Primary neoplasms of the pulmonary artery are extremely rare and usually are not recog- nized until autopsy.We present a case in which the correct preoperative diagnosis was established by cardiac catheterization.The hemodynamic and angiographic findings of sarcoma of the pulmonary artery are distinct and should not be overlooked in the evaluation of right ventricular outflow tract obstruction.PRIMARY malignant lesions of the pulmonary artery are extremely rare; to our knowledge, only 68 cases have been reported previously.' -9 Most of these case reports were based on autopsy study, and in only 17 of these patients was the correct antemortem diagnosis suggested.We describe a patient with primary leio- myosarcoma of the pulmonary trunk in whom the pre- operative diagnosis was correctly suggested by cardiac catheterization. Case ReportA 51-year-old man was referred to the Mayo Clinic for evaluation and treatment of presumed massive pul- monary thromboembolism.The patient was an active farmer with a smoking history of 25 pack-years.He had no history of leg trauma, deep vein thrombosis or hospitalization.Twelve months before the current ex- amination, the patient had noted the onset of progres- sive dyspnea on exertion.Six weeks before admission, the patient had complained of right pleuritic chest pain, scant hemoptysis, chronic cough, night sweats, an- orexia and a weight loss of 9.1 kg.Immediately before referral, right-heart catheterization performed with in- jection of contrast medium into the right atrium dem- onstrated a large filling defect in the pulmonary trunk, interpreted to be a "saddle embolus."Physical examination revealed that the patient was dyspneic at rest and had a blood pressure of 135/75 mm Hg and a regular pulse of 100 beats/min.There were prominent "V" waves in the jugular venous pulse.A sustained right ventricular lift was present.The pulmo- nary valve closure sound was accentuated.A grade 3 pulmonary ejection murmur and a grade 2 tricuspid insufficiency murmur were evident.The abdominal examination was unremarkable.No peripheral edema, adenopathy, cyanosis, clubbing or evidence of deep vein thrombosis was noted.Laboratory data included the following: hemoglobin 11.7 g/dl, total iron-binding capacity 208 g/dl, serum iron 34 g/dl, and iron saturation 16%.Results of the
Pathogenesis of the Rubella Exanthem
Authors: Alfred D. Heggie
Journal: New England Journal of Medicine (1971)

MANY of the viruses associated with vesiculopapular exanthems such as vaccinia, varicella and herpes simplex have been recovered from the skin lesions that characterize these infections. It is thought, therefore, that dermal injury in these diseases results from replication of virus in skill cells, perhaps in combination with an immunologic reaction against viral antigen deposited in this tissue.1 2 3 In rubella, however, except in its congenital form, recovery of virus from the skin has not been reported, and the role of virus in the pathogenesis of this nonvesicular, maculopapular exanthem is unknown. The purpose of this study was to determine whether . . .
Environmental Exposure to Polychlorinated Biphenyls and <i>p,p</i> ´-DDE and Sperm Sex-Chromosome Disomy
Authors: Megan E. McAuliffe, Paige L. Williams, Susan A. Korrick, Larisa M. Altshul, Melissa J. Perry
Journal: Environmental Health Perspectives (2011)

Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention.We evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p'-DDE) exposures with sperm sex-chromosome disomy.We conducted a cross-sectional study of 192 men from subfertile couples. We used multiprobe fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 57 PCB congeners and p,p'-DDE. Poisson regression models were used to calculate incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for demographic characteristics and semen parameters.The median percent disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome disomy. We observed a significant trend of increasing IRRs for increasing quartiles of p,p'-DDE in XX, XY, and total sex-chromosome disomy, and a significant trend of increasing IRRs for increasing quartiles of PCBs for XY and total sex-chromosome disomy; however, there was a significant inverse association for XX disomy.Our findings suggest that exposure to p,p'-DDE may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to PCBs may be associated with increased rates of YY, XY, and total sex-chromosome disomy. In addition, we observed an inverse association between increased exposure to PCBs and XX disomy. Further work is needed to confirm these findings.
FRACTURES INTO AND ABOUT THE ELBOW JOINT.
Authors: J. HENRY BARBAT
Journal: JAMA (1903)

Fractures involving the elbow joint, if not properly treated, will often result in impairment of function, amounting in some cases to complete ankylosis, and when we consider that even slight limitation of the movements of this joint may incapacitate an individual from following the trade of his choice, it behooves us to not neglect even apparently trivial injuries of this joint. Motion is limited by either a malposition of the fragments, the overproduction of callus or the interposition of bone fragments in the joint cavity.  The overproduction of callus is sometimes difficult to avoid; but unless the bone be comminuted we can maintain the proper relation of fragments by either nails, wire, staples or plates, and any piece of bone which finds its way into the joint cavity should be removed. Opening of the joint is fraught with much less danger, so far as the
Antimicrobial activity of mucosal-associated invariant T cells
Authors: Lionel Le Bourhis, Emmanuel Martin, Isabelle Péguillet, Amélie Guihot, Nathalie Froux, Maxime Coré, Eva Lévy, Mathilde Dusseaux, Vanina Meyssonnier, Virginie Premel, Charlotte Ngo, Béatrice Riteau, Livine Duban, Delphine Robert, Shouxiong Huang, Martin Rottman, Claire Soudais, Olivier Lantz
Journal: Nature Immunology (2010)