The Pathogenesis of Myelofibrosis in Myeloproliferative Disorders
Authors: JEROME E. GROOPMAN
Journal: Annals of Internal Medicine (1980)

Editorial Notes1 June 1980The Pathogenesis of Myelofibrosis in Myeloproliferative DisordersJEROME E. GROOPMAN, M.D.JEROME E. GROOPMAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-6-857 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pathogenesis of bone marrow fibrosis in the myeloproliferative disorders is unknown. Various other conditions, benign and malignant, that involve the marrow, including osteopetrosis, Paget's disease, thorium dioxide administration, hairy cell leukemia, and carcinoma of the breast, may also be associated with marked myelofibrosis. The bone marrow scarring in such diverse disorders probably arises via different mechanisms. My comments here focus on the genesis of marrow fibroblast proliferation in myeloproliferative disorders.Fibroblasts are the source of the silver-staining precollagen termed reticulin that replaces normal marrow stroma in disorders with myelofibrosis. Although the bone marrow fibroblast was once believed to be...References1. GOLDEHOCKINGQUANSPARKESGALE DWSRR. Origin of human bone marrow fibroblasts. Br J Haematol. 1980;44:183-7. CrossrefMedlineGoogle Scholar2. FRIEDENSTEINIVANOV-SMOLENSKICHAJLAKJAN AAR. Origin of bone marrow stromal mechanocytes in radiochimeras and heterotopic transplants. Exp Hematol. 1978;6:440-4. MedlineGoogle Scholar3. VAN SLYCKWEISSDULLY ELM. Chromosomal evidence for the secondary role of fibroblastic proliferation in acute myelofibrosis. Blood. 1970;36:729-35. CrossrefMedlineGoogle Scholar4. JACOBSONSALOFIALKOW RAP. Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. Blood. 1978;51:189-94. 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