tbuckley/cabot-search huggingface dataset:
Drunk Drivers and Medical and Social Injury
Authors: M Colquitt, L P Fielding, J F Cronan
Journal: New England Journal of Medicine (1987)

Alcohol-related traffic injuries are a major cause of death, pain, and suffering and a major contributor to health care costs in the United States. We reviewed the medical and legal consequences of 252 motor vehicle accidents involving drivers admitted to St. Mary's Hospital between 1981 and 1985, with particular attention to patients with a blood alcohol concentration equal to or above the legally defined threshold for intoxication (100 mg per deciliter). There were 84 such patients, with a median blood alcohol level of 218.5 mg per deciliter. Few of these patients were referred either to alcoholism-rehabilitation programs or to the courts for prosecution. We conclude that both drunk drivers and the population at large are poorly served by current medical and legal practices. Because denial of reality and prevarication are hallmarks of alcoholism, we make two recommendations. First, in order to encourage physicians to refer all injured patients with high blood alcohol concentrations to detoxification and rehabilitation programs, injury to intoxicated drivers should be made a reportable condition. Second, prosecution for driving under the influence of alcohol should be made easier by simplifying the procedures for providing the courts with blood alcohol measurements obtained as part of normal clinical care. Physicians must act in the interest of their patients. The two recommended changes in current practice would help provide a firm framework within which physicians could advise patients about appropriate treatment for alcoholism. If such steps are not taken or are ineffective, vigorous legal action should be encouraged, because society has the right to demand that innocent people not be endangered by intoxicated people who drive motor vehicles.
Surveillance of patients attending a diarrhoeal disease hospital in Bangladesh
Authors: B. J Stoll, R. I Glass, M I. Huq, M U Khan, J. E Holt, H. Banu
Journal: BMJ (1982)

In October 1979 a surveillance system was set up at the International Centre for Diarrhoeal Disease Research, Bangladesh, Hospital at Dacca to study a 4% systematic sample of the 100 000 patients with diarrhoea who come to the hospital for care each year. From December 1979 to November 1980 inclusive, 3550 patients were studied. A recognised pathogenic organism was identified for 66% of patients screened for all pathogens, one-third of whom had a mixed infection with two or more agents. Enterotoxigenic Escherichia coli was the most common enteropathogen detected in all age groups (detection rate 20%), followed by rotavirus (19%), Campylobacter jejuni (14%), and Shigella (12%). Infants and young children (up to 5 years) were most often infected with rotavirus, enterotoxigenic E coli, and C jejuni and older children (5-14 years) had more infections with enterotoxigenic E coli, Shigella, and E histolytica. Surveillance has helped to define the range of disease among patients attending the Dacca Hospital. Sixty-five per cent of patients complained of watery diarrhoea, a presentation that was significantly more common in patients with Vibrio cholerae 0:1 (91%), enterotoxigenic E coli (78%), rotavirus (77%), and C jejuni (71%) than in all patients studied. Dysentery, defined as a history of diarrhoea with blood, was the presenting complaint of 20% of all patients but 55% of those with Shigella. Only patients with V cholerae 0:1 and enterotoxigenic E coli were at increased risk for severe dehydration. In addition surveillance has been used to identify areas where patient care can be improved and to generate new ideas for research.
Bill is not fit to be amended
Authors: J. P. Tomlinson
Journal: BMJ (2011)

The King’s Fund should be bold and declare that the proposed NHS reforms will worsen the existing problems of poor communication and collaboration in the NHS.1 They will not address poor standards of care and will widen inequalities.

The potentially beneficial parts of the bill, such as greater clinician participation in decision making, are too tightly hitched to the most damaging parts, such as the purchaser-provider split and the external market. The damaging parts of the bill are so dangerous that no amount of amending can make it …
GW25-e3399 Catheter-based renal denervation lowers blood pressure in hypertensive mini-pigs
Authors: Shuangtao Ma, Dan Li, Qiang Wang, Yan Zhang, Dachun Yang, Linan Su, Tingqiao Ye, Xi Zheng, Liping Zhang, De Li, Yongjian Yang
Journal: Journal of the American College of Cardiology (2014)
Letter by Chyrchel et al Regarding Article, “Unexpected Effect of Proton Pump Inhibitors: Elevation of the Cardiovascular Risk Factor Asymmetric Dimethylarginine”
Authors: Bernadeta Chyrchel, Michał Chyrchel, Andrzej Surdacki
Journal: Circulation (2014)

Ghebremariam et al 1 brilliantly demonstrated that proton pump inhibitors (PPIs) inhibit dimethylarginine dimethylaminohydrolase, a key enzyme metabolizing the endogenous nitric oxide synthase antagonist asymmetrical dimethylarginine.This finding offers a novel mechanism for the putative ability of PPIs to attenuate benefits of antiplatelet agents, an effect initially attributed to the interaction of PPIs with clopidogrel activation by a hepatic enzyme (CYP2C19). 2To prevent this interaction, staggered dosing of clopidogrel and PPIs was proposed. 2Our group reported lower platelet aggregatory responses to adenosine diphosphate in coronary artery disease subjects receiving clopidogrel ≈15 hours after omeprazole compared with patients being given both drugs simultaneously, 3 which was interpreted as a probable consequence of impaired CYP2C19-dependent clopidogrel activation because of high omeprazole levels. 3owever, after the study by Ghebremariam et al, 1 an alternative explanation for our observation may be proposed.Because our subjects who were randomly assigned to concomitant but not staggered intake of clopidogrel and omeprazole were exposed to high circulating omeprazole for ≈3 hours before blood sampling, the PPI-induced reversible dimethylarginine dimethylaminohydrolase inhibition could result in elevated asymmetrical dimethylarginine and depressed nitric oxide bioavailability at the time of platelet function testing.Whether this mechanism might have contributed to higher platelet reactivity on concomitant dosing of the both drugs remains unclear.Nevertheless, that Kirkby et al 4 recently reported a 1000-to 100 000-fold increase in nitric oxide antiplatelet effect after platelet P2Y 12 receptor blockade, implies enhanced platelet sensitivity to asymmetrical dimethylarginine on P2Y 12 inhibition.Therefore, if clinically confirmed, the PPIdimethylarginine dimethylaminohydrolase interaction can explain adverse cardiovascular prognostic PPIs effects not only in patients taking clopidogrel but also those taking ticagrelor, a P2Y 12 inhibitor not requiring biotransformation.
Symbolic Apperception and Integral Psychology
Authors: Robert Gerard
Journal: Psychotherapy and Psychosomatics (1974)

Research Articles| February 12 2010 Symbolic Apperception and Integral Psychology Subject Area: Psychiatry and Psychology Robert Gerard Robert Gerard Los Angeles Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1974) 24 (4-6): 471–481. https://doi.org/10.1159/000286787 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Robert Gerard; Symbolic Apperception and Integral Psychology. Psychother Psychosom 31 December 1974; 24 (4-6): 471–481. https://doi.org/10.1159/000286787 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1974Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Pulmonary Capillary Blood Volume in Hyperpnea-induced Bronchospasm
Authors: DAVID A. KAMINSKY, MARY LYNN
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Reactive hyperemia of the bronchial circulation has been postulated to contribute to the airway narrowing that occurs following exercise or hyperpnea in subjects with asthma with hyperpnea-induced bronchospasm (HIB). Changes in lung parenchymal mechanics also occur in HIB, including increases in peripheral airway resistance. Since the peripheral airways and lung parenchyma are supplied by the pulmonary circulation, and changes in the pulmonary circulation could alter airway resistance or tissue mechanics, we hypothesized that pulmonary capillary blood flow would increase in association with HIB, resulting in increases in pulmonary capillary blood volume (VC). We measured VC by using two test gases of varying oxygen concentration to determine the diffusing capacity of the lung for carbon monoxide (DL(CO)) before and after a period of hyperpnea in 13 subjects with asthma with HIB and 10 control subjects without asthma. Despite subjects with asthma having a significant fall in FEV(1) following hyperpnea compared with control subjects (DeltaFEV(1) = -26 +/- 12 versus -4 +/- 4%, mean +/- SD, p < 0.001), there was no change in the DL(CO) or VC from baseline values. We conclude that pulmonary capillary blood volume does not change following hyperpnea, and therefore that changes in pulmonary blood flow are not associated with HIB.
Avoidance of Misinterpretation of an FDG Positive Sacral Insufficiency Fracture Using PET/CT Scans in a Patient With Endometrial Cancer: A Case Report
Authors: Metin Halaç, Sanem Senyuz Mut, Kerim Sönmezoglu, Mehmet H. Ylmaz, Harun Ozer, Ilhami Uslu
Journal: Clinical Nuclear Medicine (2007)

Whole-body FDG PET is an important tool for imaging of cancer, including skeletal metastases. However, false-positive results can occur in benign diseases such as insufficiency fractures. We report a case of sacral insufficiency fracture in which increased FDG uptake was detected. Correlative CT images obtained by a combined PET/CT scanner excluded a possible false-positive interpretation by revealing the fracture lines at the site of increased FDG uptake.
<i>In vitro</i> hymenoptera venom allergy diagnosis: improved by screening for cross‐reactive carbohydrate determinants and reciprocal inhibition
Authors: U. Jappe, M. Raulf‐Heimsoth, M. Hoffmann, G. Burow, C. Hübsch‐Müller, A. Enk
Journal: Allergy (2006)

Background: Immunoglobulin (Ig) E‐double positivity for honeybee (HB) and yellow jacket (YJ) venom causes diagnostic difficulties concerning therapeutical strategies. The aim of this study was to clarify the cause and relation of the cross‐reactivity in patients with insect venom allergy. Methods: For this purpose, 147 patients with suspected stinging insect allergy and CAP‐FEIA‐double positivity were investigated for specific sIgE to additional cross‐reactive carbohydrate determinant (CCD)‐containing allergens: timothy grass pollen, rape pollen, natural rubber latex (NRL), bromelain, and horseradish peroxidase (HRP). Sera with sIgE to NRL were further investigated with the commercially available recombinant latex allergens. Reciprocal inhibition assays with both venoms and HRP were performed. Results: About 36 of 147 (24.5%) patients had sIgE to both venoms only. However, 111 of 147 (75.5%) additionally reacted to CCD‐carrying allergens. 89 of 111 CCD‐reactive sera had NRL‐sIgE. In cases where inhibition experiments were performed, the NRL‐sIgE binding was completely abolished in the presence of HRP. Only nine of 61 sera were positive for at least one recombinant latex allergen; all of them were negative in history and NRL‐skin prick test. In 43 sera containing sIgE to CCD, HRP inhibition revealed unequivocal results: In 28 of 43 (65%) an HRP‐inhibition &gt;70% of sIgE to one venom occurred, pointing out the relevant venom. In three of 43 sIgE proved to be entirely CCD‐specific. Conclusions: Our data indicate that in cases of IgE positivity to both insect venoms supplementary screening tests with at least one CCD‐containing allergen should be performed; HRP being a suitable tool for this test. In addition, subsequent reciprocal inhibition is an essential diagnostic method to specify cross‐reacting sIgE results.
Serum Vitamin D and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Screening Trial
Authors: Rachael Z. Stolzenberg-Solomon, Richard B. Hayes, Ron L. Horst, Kristin E. Anderson, Bruce W. Hollis, Debra T. Silverman
Journal: Cancer Research (2009)

Experimental evidence suggests that vitamin D has anticarcinogenic properties; however, a nested case-control study conducted in a population of male Finnish smokers found that higher 25-hydroxyvitamin D [25(OH)D], the best indicator of vitamin D status as determined by the sun and diet, was associated with a significant 3-fold increased risk for pancreatic cancer. We conducted a nested case-control study in the Prostate, Lung, Colorectal, and Ovarian Screening Trial cohort of men and women 55 to 74 years of age at baseline to test whether prediagnostic serum 25(OH)D concentrations were associated with pancreatic cancer risk. Between 1994 and 2006, 184 incident cases of pancreatic adenocarcinoma occurred (follow-up to 11.7 years). Two controls (n = 368) who were alive at the time the case was diagnosed were selected for each case and matched by age, race, sex, and calendar date of blood draw (to control for seasonal variation). We calculated odds ratios (OR) and 95% confidence intervals (95% CI) using conditional logistic regression, adjusting for smoking and body mass index. Vitamin D concentrations were not associated with pancreatic cancer overall (highest versus lowest quintile, >82.3 versus <45.9 nmol/L: OR, 1.45; 95% CI, 0.66-3.15; P trend = 0.49). However, positive associations were observed among subjects with low estimated annual residential solar UBV exposure, but not among those with moderate to high annual exposure (P interaction = 0.015). We did not confirm the previous strong positive association between 25(OH)D and pancreatic cancer; however, the increased risk among participants with low residential UVB exposure is similar.
MENINGOCOCCAL MENINGITIS
Authors: EUGENE P. CAMPBELL
Journal: Annals of Internal Medicine (1942)

Article1 April 1942MENINGOCOCCAL MENINGITISREPORT OF FIFTY CASES, FORTY TREATED WITH SERUM AND TEN TREATED WITH SERUM AND SULFANILAMIDE*EUGENE P. CAMPBELL, M.D.EUGENE P. CAMPBELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-4-694 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past decade we have witnessed important changes in the therapeutic regimen of meningococcal meningitis. The traditional method of administering serum intrathecally has been generally discontinued in favor of the intravenous route. New and improved methods of making serum have resulted in the introduction of highly concentrated antiserum and antitoxin. Supporters of serum and antitoxin using new methods of administration of these biological preparations have claimed promising results. It almost goes without saying, however, that the general fatality from this disease has remained high in spite of these innovations. It is for the purpose of critical analysis of a...Bibliography1. WHITBY L: Chemotherapy of bacterial infection, Lancet, 1938, ii, 1095-1103. CrossrefGoogle Scholar2. LONGBLISS PHEA: The clinical and experimental use of sulfanilamide, sulfapyridine and allied compounds, 1939, Macmillan Co., New York. Google Scholar3. FLIPPINSCHWARTZROSE HFLSB: The comparative effectiveness and toxicity of sulfathiazole and sulfapyridine in pneumococcic pneumonia, ANN. INT. MED., 1940, xiii, 2038-2049. Google Scholar4. BRANHAM SE: The effect of sulfapyridine and sulfanilamide with and without serum in experimental meningococcus infection, Pub. Health Rep., 1937, lii, 1143-1150. CrossrefGoogle Scholar5. BRANHAM SE: The meningococcus (Neisseria intracellularis), Bact. Rev., 1940, iv, 59-96. CrossrefGoogle Scholar6. CAMPBELL EP: Meningococcal meningitis, Med. Ann. District of Columbia, 1939, viii, 132-135. Google Scholar7. CARBONELLCAMPBELL AEP: Prolonged meningococcemia, Arch. Int. Med., 1938, lxi, 646-654. CrossrefGoogle Scholar8. STALLYBRASS CO: The principles of epidemiology and the process of infection, 1931, Macmillan Co., New York, p. 276. Google Scholar9. SHAFFERFREEMAN HWJT: Epidemic meningitis, second attack with recovery, 2 cases, Jr. Lab. and Clin. Med., 1937, xxii, 1010-1013. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EUGENE P. CAMPBELL, M.D.*Received for publication June 14, 1941.From the Medical Service of the Philadelphia General Hospital, under the directorship of Dr. Russell S. Boles. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMENINGOCOCCIC INFECTIONS WITH SPECIAL REFERENCE TO CERTAIN DIAGNOSTIC CONSIDERATIONS; AN ANALYSIS OF THIRTY-SEVEN CASES*ALBERT C. OXMAN, ISIDORE FISCHER 1 April 1942Volume 16, Issue 4 Page: 694-700 Keywords Antitoxins Medical services Meningitis ePublished: 1 December 2008 Issue Published: 1 April 1942 PDF downloadLoading ...
Beyond the Obesity Paradox in Diabetes
Authors: Hermes Florez, Sumaya Castillo-Florez
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
It was Diphtheria that Killed them, in Montmorency and Otsego Counties.
Authors: Henry B. Baker
Journal: JAMA (1890)

<h3>To the Editor:</h3> —The outbreak of dangerous disease which has prevailed in Otsego and Montmorency counties since last spring, and which local physicians said was not diphtheria, and permitted two of the corpses to be sent to Lapeer county, where a case of diphtheria occurred in a person who viewed the remains, has been investigated by the State Board of Health, the investigation having been requested by a union meeting of the boards of health of three townships in those counties. Prof. Vaughan, of the University, a member of the State Board of Health, went and made the investigation. He has also made bacteriological examinations of the membrane from the throats of two of the patients, and has found and propagated the microörganisms which are believed to cause diphtheria. This species of microörganism is known as Löffler's bacillus. Prof. Vaughan says: "The bacilli have been compared with the Löffler bacillus,
Progressive Confusion, Memory Loss, and Gait Ataxia in an Adult
Authors: Brian J. Dlouhy, Jeremy D. W. Greenlee
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal