Modest Weight Gain and the Development of Diabetes: Another Perspective
Authors: James R. Sowers
Journal: Annals of Internal Medicine (1995)

Editorials1 April 1995Modest Weight Gain and the Development of Diabetes: Another PerspectiveJames R. Sowers, MDJames R. Sowers, MDWayne State University, Detroit, MI 48201Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-7-199504010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Significant obesity is associated with metabolic abnormalities that are considered to be risk factors for cardiovascular disease, including impaired glucose tolerance and non-insulin-dependent diabetes mellitus, hypertension, and an abnormal lipoprotein profile [1-3]. The National Institutes of Health Consensus Development Panel [4] concluded in 1985 that “the evidence is now overwhelming that obesity, defined as excessive storage of energy in the form of fat, has adverse effects on health and longevity.” If obesity is defined as a body mass index of 20% above the desirable index (roughly a body mass index of 27 kg/m2), approximately 34 million adult Americans can be ...References1. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, et al. Hyperinsulinemia. A link between hypertension obesity and glucose intolerance. J Clin Invest. 1985; 75:809-17. Google Scholar2. Stevens J, Keil JE, Rust PF, Verdugo RR, Davis CE, Tyroler HA, et al. Body mass index and body girths as predictors of mortality in black and white women. Arch Intern Med. 1992; 152:1257-62. Google Scholar3. Despres JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. 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Effect of weight reduction glucose tolerance in obesity. A follow-up study of five years. In: Howard AN, ed. Recent Advances in Obesity Research. London: Newman Publishers; 1975:128-33. Google Scholar10. Holbrook TL, Barrett-Connor E, Wingard DL. The association of lifetime weight and weight control patterns with diabetes among men and women in an adult community. Int J Obesity. 1989; 13:723-9. Google Scholar11. Pouliot MC, Despres JP, Nadeau A, Moorjani S, Prud'Homme D, Lupien PJ, et al. Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes. 1992; 41:826-34. Google Scholar12. Spiegelman D, Israel RG, Bouchard C, Willett WC. Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? Am J Clin Nutr. 1992; 55:1033-44. Google Scholar13. Haffner SM, Karhapaa, Mykkanen L, Laakso M. Insulin resistance, body fat distribution, and sex hormones in men. Diabetes. 1994; 43:212-9. Google Scholar14. Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest. 1983; 72:1150-62. Google Scholar15. Reaven GM. Bating lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988; 37:1595-607. Google Scholar16. Flack JM, Sowers JR. Epidemiologic and clinical aspects of insulin resistance and hyperinsulinemia. Am J Med. 1991; 91(1A):11S-21S. Google Scholar17. Bonham GS, Brock DB. The relationship of diabetes with race, sex, and obesity. Am J Clin Nutr. 1985; 41:776-83. Google Scholar18. Monolio TA, Savage PJ, Burke GL, Liu KA, Wagenknecht LE, Sidney S, et al. Association of fasting insulin with blood pressure and lipids in young adults. The CARDIA study. Arteriosclerosis. 1990; 10:430-6. Google Scholar19. Haffner SM. Hyperinsulinemia as a possible etiology for the high prevalence of non-insulin dependent diabetes in Mexican Americans. Diabetes Metab. 1987; 13:337-44. Google Scholar Author, Article, and Disclosure InformationAuthors: James R. Sowers, MDAffiliations: Wayne State University, Detroit, MI 48201Corresponding Author: James R. Sowers, MD, Division of Endocrinology and Hypertension, Wayne State University School of Medicine, UHC-4H, 4201 St. Antoine, Detroit, MI 48201. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWeight Gain as a Risk Factor for Clinical Diabetes Mellitus in Women Graham A. Colditz , Walter C. Willett , Andrea Rotnitzky , and JoAnn E. Manson Metrics Cited byANTIHYPERTENSIVE PHARMACOTHERAPY IN HYPERTENSIVE PATIENTS AT A TERTIARY CARE TEACHING HOSPITAL AND MEDICAL COLLEGE IN INDIAContinuous Glucose Monitoring in Patients Undergoing Cardiac SurgeryPregnancy: a “teachable moment” for weight control and obesity preventionObesity in Middle and Older AgeTreatment of cardiac risk factors in diabetic patients: How well do we follow the guidelines?Obesity, hypertension, and vascular diseaseObesity and cardiovascular diseaseTherapeutic challenges in the obese diabetic patient with hypertensionDiabetes Mellitus and Hypertension, Emerging Therapeutic Perspectives 1 April 1995Volume 122, Issue 7Page: 548-549KeywordsAdipose tissueBody mass indexFatsInsulinInsulin resistanceLongitudinal studiesObesityOverweightType 2 diabetesWeight gain ePublished: 15 August 2000 Issue Published: 1 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...