tbuckley/cabot-search huggingface dataset:
Time course of 8-MOP-induced skin photosensitization in PUVA bath photochemotherapy
Authors: M. Kerscher, C. Gruss, G. von Kobyletzki, M. Volkenandt, N.J. Neumann, P. Altmeyer, P. Lehmann
Journal: British Journal of Dermatology (1997)

Journal Article Time course of 8‐MOP‐induced skin photosensitization in PUVA bath photochemotherapy Get access M. Kerscher, M. Kerscher Department of Dermatology, Ruhr‐University Bochum, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar C. Gruss, C. Gruss Department of Dermatology, Ruhr‐University Bochum, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar G. von Kobyletzki, G. von Kobyletzki Department of Dermatology, Ruhr‐University Bochum, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar M. Volkenandt, M. Volkenandt Department of Dermatology, Ludwig‐Maximilians‐University, München, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar N.J. Neumann, N.J. Neumann Department of Dermatology, Heinrich‐Heine‐University, Düsseldorf, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar P. Altmeyer, P. Altmeyer Department of Dermatology, Ruhr‐University Bochum, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar P. Lehmann P. Lehmann Department of Dermatology, Heinrich‐Heine‐University, Düsseldorf, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 3, 1 March 1997, Pages 473–474, https://doi.org/10.1111/j.1365-2133.1997.tb14978.x Published: 01 March 1997
Effects of a new selective A2a adenosine receptor agonist on Thallium-201 and Tcm99-MIBI biodistribution and clearance: Implications for optimizing vasodilator stress perfusion imaging
Authors: Farid Jadbabaie, David F. Meoli, Brian N. Bourke, Kailasnath Purushothaman, Stacy Sullivan, Luiz Belardinelli, Albert J. Sinusas
Journal: Journal of the American College of Cardiology (2003)
Prevalence of Diagnosed Diabetes Among American Indians and Alaska Natives, 1987: Estimates from a national outpatient data base
Authors: Sarah Valway, William Freeman, Stephen Kaufman, Thomas Welty, Steven D Helgerson, Dorothy Gohdes
Journal: Diabetes Care (1993)

To estimate the prevalence of diagnosed diabetes among American Indians and Alaska Natives served by the IHS.This was a cross-sectional study of the 1987 IHS national outpatient data base.Prevalence rates of diagnosed diabetes determined from the IHS outpatient data base were consistent with recent studies of diabetes in different IHS areas. IHS-wide, age-adjusted prevalence was 69/100,000, or 2.8 times the U.S. rate. There was considerable variation in prevalence rates of diabetes throughout the country, with rates ranging from 15.3/100,000 in Alaska to 119.2/100,000 in southern Arizona.This study documented the high prevalence of diabetes among American Indians and Alaska Natives and the wide variation in rates between different tribal groups. This study also demonstrated the feasibility of using an outpatient data base to estimate rates of disease that have uniform methods of diagnosis and result in frequent clinic visits.
An evaluation of the significance of microscopic colitis in patients with chronic diarrhea.
Authors: G W Bo-Linn, D D Vendrell, E Lee, J S Fordtran
Journal: Journal of Clinical Investigation (1985)

Some patients with chronic idiopathic diarrhea have an apparent nonspecific inflammation of colonic mucosa, even though their colons appear normal by barium enema and colonoscopy. This has been referred to as microscopic colitis. However, the significance of this finding is unclear, because the ability of pathologists to accurately distinguish mild degrees of abnormality has not been established. Furthermore, even if the mucosa of these patients is nonspecifically inflamed, it is not known whether this is associated with deranged colonic function that could contribute to the development of chronic diarrhea. To assess these questions, we first examined colonic biopsy specimens in a blinded fashion, comparing biopsy results from patients with microscopic colitis with biopsy specimens from subjects in two control groups. This analysis revealed that colonic mucosa from six patients with microscopic colitis was in fact abnormal. For example, their mucosa contained an excess of both neutrophiles and round cells in the lamina propria, cryptitis, and reactive changes. These and other differences were statistically significant. Second, colonic absorption, measured by the steady state nonabsorbable marker perfusion method, was severely depressed in the patients. For example, mean water absorption rate was 159 ml/h in normal subjects and was reduced to only 26 ml/h in six patients with microscopic colitis. Results of net and unidirectional electrolyte fluxes and of electrical potential difference suggested that colonic fluid absorption was abnormal because of reduced active and passive sodium and chloride absorption and because of reduced Cl/HCO3 exchange. Small intestinal fluid and electrolyte absorption was abnormally reduced in two of the six patients, suggesting the possibility of coexistent small intestinal involvement in some of these patients. We conclude that nonspecific inflammation of colonic mucosa is associated with a severe reduction of colonic fluid absorption, and that the latter probably contributes to the development of chronic diarrhea.
Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse
Authors: J. Michael Gee, Nathan A. Smith, Fernando R. Fernandez, Michael N. Economo, Daniela Brunert, Markus Rothermel, S. Craig Morris, Amy Talbot, Sierra Palumbos, Jennifer M. Ichida, Jason D. Shepherd, Peter J. West, Matt Wachowiak, Mario R. Capecchi, Karen S. Wilcox, John A. White, Petr Tvrdik
Journal: Neuron (2014)
Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion.
Authors: G T Huang, L Eckmann, T C Savidge, M F Kagnoff
Journal: Journal of Clinical Investigation (1996)

The acute host response to gastrointestinal infection with invasive bacteria is characterized by an accumulation of neutrophils in the lamina propria, and neutrophil transmigration to the luminal side of the crypts. Intestinal epithelial cells play an important role in the recruitment of inflammatory cells to the site of infection through the secretion of chemokines. However, little is known regarding the expression, by epithelial cells, of molecules that are involved in interactions between the epithelium and neutrophils following bacterial invasion. We report herein that expression of ICAM-1 on human colon epithelial cell lines, and on human enterocytes in an in vivo model system, is upregulated following infection with invasive bacteria. Increased ICAM-1 expression in the early period (4-9 h) after infection appeared to result mainly from a direct interaction between invaded bacteria and host epithelial cells since it co-localized to cells invaded by bacteria, and the release of soluble factors by epithelial cells played only a minor role in mediating increased ICAM-1 expression. Furthermore, ICAM-1 was expressed on the apical side of polarized intestinal epithelial cells, and increased expression was accompanied by increased neutrophil adhesion to these cells. ICAM-1 expression by intestinal epithelial cells following infection with invasive bacteria may function to maintain neutrophils that have transmigrated through the epithelium in close contact with the intestinal epithelium, thereby reducing further invasion of the mucosa by invading pathogens.
Treatment of Refractory Mesial Temporal Lobe Epilepsy—Reply
Authors: Jerome Engel, Michael P. McDermott, John T. Langfitt
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Variation in an miRNA-1827 Binding Site in <i>MYCL1</i> Alters Susceptibility to Small-Cell Lung Cancer
Authors: Fang Xiong, Chen Wu, Jiang Chang, Dianke Yu, Binghe Xu, Peng Yuan, Kan Zhai, Jian Xu, Wen Tan, Dongxin Lin
Journal: Cancer Research (2011)

Genetic variations in microRNAs (miRNA) that affect control of their target genes may alter individual susceptibilities to cancer. In this study, we took an in silico approach to identify single-nucleotide polymorphisms (SNP) within the 3'-untranslated region (UTR) of miRNA genes deregulated in human small-cell lung cancer (SCLC), and then investigated their associations with SCLC susceptibility in 666 SCLC patients and 758 controls. Odds ratios (OR) were estimated by multivariate logistic regression, and biochemical assays were conducted to investigate SNP functions. We identified 2 SNPs, rs3134615 and rs2291854, which were located in the 3'-UTR of the L-MYC gene MYCL1 and the neuronal development Achaete-Scute Complex homolog ASCL1. Case-control analyses showed that the rs3134615T allele was associated with a significantly increased risk of SCLC, with the OR for carrying the GT or TT genotype being 2.08 (95% confidence interval, 1.39-3.21; P = 0.0004) compared with the GG genotype. In support of the likelihood that these 3'-UTR SNPs may directly affect miRNA-binding sites, reporter gene assays indicated MYCL1 as the target of hsa-miR-1827 and the rs3134615 G>T change resulted in altered regulation of MYCL1 expression. Our findings define a 3'-UTR SNP in the human L-MYC oncogene that may increase susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827.
Selective targeting of CTNBB1-, KRAS- or MYC-driven cell growth by combinations of existing drugs
Authors: G. Zaman, J. Uitdehaag, J. De Roos, A. Van Doornmalen, M. Prinsen, J. Spijkers-Hagelstein, J. De Vetter, J. De Man, R. Buijsman
Journal: Annals of Oncology (2015)
Cyclooxygenase (COX) inhibition at the time of initial antigen presentation results in enhanced IL-13 and IgE
Authors: P.W. Jones, K. Goleniewska, J. Furlong, J.R. Sheller, K. Hashimoto, J.D. Morrow, R.S. Peebles
Journal: Journal of Allergy and Clinical Immunology (2003)
Oxford Textbook of Medicine, vols 1-3
Authors: R. R. Hariharan
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-l-lysine
Authors: Nicholas J. Boylan, Anthony J. Kim, Jung Soo Suk, Pichet Adstamongkonkul, Brian W. Simons, Samuel K. Lai, Mark J. Cooper, Justin Hanes
Journal: Biomaterials (2011)
Renal and Hormonal Responses to Direct Renin Inhibition With Aliskiren in Healthy Humans
Authors: Naomi D.L. Fisher, A.H. Jan Danser, J. Nussberger, William P. Dole, Norman K. Hollenberg
Journal: Circulation (2008)

Pharmacological interruption of the renin-angiotensin system focuses on optimization of blockade. As a measure of intrarenal renin activity, we have examined renal plasma flow (RPF) responses in a standardized protocol. Compared with responses with angiotensin-converting enzyme inhibition (rise in RPF approximately 95 mL x min(-1) x 1.73 m(-2)), greater renal vasodilation with angiotensin receptor blockers (approximately 145 mL x min(-1) x 1.73 m(-2)) suggested more effective blockade. We predicted that blockade with the direct oral renin inhibitor aliskiren would produce renal vascular responses exceeding those induced by angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.Twenty healthy normotensive subjects were studied on a low-sodium (10 mmol/d) diet, receiving separate escalating doses of aliskiren. Six additional subjects received captopril 25 mg as a low-sodium comparison and also received aliskiren on a high-sodium (200 mmol/d) diet. RPF was measured by clearance of para-aminohippurate. Aliskiren induced a remarkable dose-related renal vasodilation in low-sodium balance. The RPF response was maximal at the 600-mg dose (197+/-27 mL x min(-1) x 1.73 m(-2)) and exceeded responses to captopril (92+/-20 mL x min(-1) x 1.73 m(-2); P<0.01). Furthermore, significant residual vasodilation was observed 48 hours after each dose (P<0.01). The RPF response on a high-sodium diet was also higher than expected (47+/-17 mL x min(-1) x 1.73 m(-2)). Plasma renin activity and angiotensin levels were reduced in a dose-related manner. As another functional index of the effect of aliskiren, we found significant natriuresis on both diets.Renal vasodilation in healthy people with the potent renin inhibitor aliskiren exceeded responses seen previously with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. The effects were longer lasting and were associated with significant natriuresis. These results indicate that aliskiren may provide more complete and thus more effective blockade of the renin-angiotensin system.
Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders
Authors: S. Goriely, R. Cavoy, M. Goldman
Journal: Allergy (2009)

Cytokines produced by antigen‐presenting cells govern the fate of helper T‐cell responses. Herein, we review the impact of interleukin (IL)‐23 and IL‐27 on the outcome of T‐helper (Th) 17 cell responses and discuss their impact in the pathogenesis of T‐cell‐mediated inflammatory disorders of autoimmune or allergic origin. We then discuss how type I interferons might influence the course of autoimmune diseases by tipping the balance between IL‐12 family members.
A STUDY OF THE INHIBITION OF STREPTOCOCCAL PROTEINASE BY SERA OF NORMAL AND IMMUNE ANIMALS AND OF PATIENTS INFECTED WITH GROUP A HEMOLYTIC STREPTOCOCCI
Authors: Edgar W. Todd
Journal: The Journal of Experimental Medicine (1947)

Antiproteinase sera were prepared by immunizing horses with filtrates from a selected strain of group A streptococcus. This strain, which produced high titred proteinase but no erythrogenic toxin, was selected from forty-two strains of group A streptococci which produced varying amounts of proteinase. A few strains belonging to groups B, C, and G were also tested; they were all proteinase-negative. Methods are described for titrating streptococcal proteinase in crude culture filtrates and for measuring the antiproteinase activity of serum. The antiproteinase titres of sera from immunized horses ranged from 125 units to 1,000 units per cc. in contrast to the low titres of normal horse sera, only 5 per cent of which had titres as high as 10 to 30 units per cc. The available evidence suggests that the antiproteinase activity of immune sera is dependent on the action of specific antibody for streptococcal proteinase. Patients infected with group A streptococci do not develop high anti-proteinase titres. There appears to be no correlation between the occurrence of rheumatic fever and the antiproteinase titre of the patient's serum.
PET may image the gates of awareness, not its center
Authors: Eric Halgren
Journal: Behavioral and Brain Sciences (1995)

Abstract PET detects changes in metabolism between task periods and is thus insensitive to areas that are activated during all or most of cognition. Depth-recorded, evokedpotentials indicate that many multimodal and limbic cortical areas may be activated during most cognitive tasks. Thus, PET may be insensitive to some core processes of awareness that are difficult to eliminate from the control periods.
The use of biochemical assays in epidemiologic studies of reproduction.
Authors: A J Wilcox, D D Baird, C R Weinberg, E G Armstrong, P I Musey, R E Wehmann, R E Canfield
Journal: Environmental Health Perspectives (1987)

Recent progress in the assay of urinary hormones has opened new opportunities for epidemiologists to study hormones and health outcomes. This is especially true for studies of female reproduction. The cyclic nature of female reproduction can be fully described only by continuous frequent measurements that, in order to be practical, require easily collected biological specimens. We describe our experience in collecting and analyzing daily urine specimens from 301 healthy women. We conclude that this approach is not only feasible but potentially of great value to epidemiologists for studying fertility, early pregnancy, the effects of toxic exposures on reproduction, and the relationships between reproduction and later risk of chronic diseases.
A FURTHER CONSIDERATION OF COMPLEMENT FIXATION IN TUBERCULOSIS
Authors: V. H. MOON
Journal: JAMA (1918)

befare its birth?If it does, then there is some good sense in feeding a child at four-hour intervals, which would not have been fed anything if it had remained those four extra weeks in utero.I think it is a question whether it even needs to be fed as often as Dr. Taylor suggests.But since we can¬ not make rules for every child, we must adopt separate rules for each child, as I am sure that some premature children must be fed oftener than other equally premature children.Dr. Abraham Jacobi, New York: I believe, as has been said, that every case has to be treated individually.You have to use your brains.I believe every one who has spoken was correct-correct in his own case-but only in his own case.We should study the babies and study the babies' mothers, and we will be better off.I am
Misdiagnosis of Multidrug-Resistant Tuberculosis Possibly Due to Laboratory-Related Errors
Authors: Annette Tsugie Nitta
Journal: JAMA (1996)

<h3>Objective.</h3> —To describe 9 cases where a misdiagnosis of multidrug-resistant tuberculosis (MDR TB) was made, possibly due to laboratory-related errors. <h3>Design.</h3> —Case series. <h3>Setting.</h3> —Public and private hospitals, outpatient clinics, and mycobacteriology laboratories serving those institutions in Los Angeles County, Calif. <h3>Patients.</h3> —Consecutive sample of 70 patients diagnosed with MDR TB who were identified between August 1993 and August 1994 by the Multidrug-Resistant Unit within TB Control in Los Angeles County. <h3>Outcome Measure.</h3> —Detection of laboratory-related diagnostic errors. <h3>Results.</h3> —Pulmonary MDR TB was misdiagnosed in 9 (13%) of 70 patients. Reasons why the diagnoses appeared to be erroneous are as follows: growth of MDR TB from an old tuberculous lesion in a patient who was never treated for TB and whose diagnosis predated anti-TB drugs (1 case), documented contamination with<i>Mycobacterium avium</i>complex (1 case), suspected cross-contamination (1 case), suspected specimen mislabeling (1 case), successful treatment using drugs to which the isolate was reportedly resistant (4 cases), discrepant susceptibility test results on additional sputum specimens submitted by the patient (2 cases), and no clinical evidence of TB (3 cases). <h3>Conclusions.</h3> —These cases emphasize the diagnostic errors that can occur if mycobacterial susceptibility results are not correlated with all clinical data including other laboratory results for a given patient. We conclude that susceptibility results alone are not enough to dictate treatment, and that careful clinical correlation is necessary in making the diagnosis of MDR TB.
Idiopathic Spinal Cord Herniation
Authors: Robert Goetti, David Wille, Ute Kretzschmar, Andrea Klein, Ianina Scheer
Journal: JAMA Neurology (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
MEP moves to increase information to patients on prescription drugs
Authors: R. Watson
Journal: BMJ (2010)

A Swedish member of the European parliament, Christofer Fjellner, has acknowledged that he will be challenging many medical professionals in steering draft legislation through the parliament that would allow pharmaceutical companies to give more information to patients about prescription drugs.

The MEP, a Christian Democrat, has assessed the European Commission’s legislative proposal, and he will present his assessment to the European parliament’s environment committee before the end of the month. Speaking after a workshop in Brussels on 4 March on the subject, he set out his approach.

He said, “It is clear there are big cultural differences in Europe …
Adaptive Value of Respiratory Adjustments to Shunt Hypoxia and to Altitude Hypoxia1
Authors: George Husson, A. B. Otis
Journal: Journal of Clinical Investigation (1957)

Pulmonary ventilationNumerous investigators have shown that indi- viduals who are chronically hypoxic from pro- longed residence at high altitudes have an in- creased ventilation which is greater the higher the altitude.There is evidence in the literature that