Norfloxacin and Warfarin
Authors: Terry Linville
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 May 1989Norfloxacin and WarfarinTerry Linville, MD, Dean Matanin, PharmDTerry Linville, MD, Dean Matanin, PharmDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-9-751_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Norfloxacin (Noroxin, Merck Sharp & Dohme, West Point, Pennsylvania) was the first of the fluorinated quinolone group of antimicrobial agents to be released by the Food and Drug Administration. Noroxin is a fluorinated quinolone derivative structurally related to nalidixic acid (NegGram, Winthrop/Breon, New York, New York). Nalidixic acid was originally synthesized in 1962 and is the prototype of a class of drugs known as quinolones. When compared with nalidixic acid, norfloxacin has a quinolone ring in place of a 1,8-napthyridine molecule. The addition of a 1-piperazinyl group at the 7-position of the quinolone ring confers antipseudomonal activity...References1. Hoffbrand B. Interaction of nalidixic acid and warfarin [Letter]. Br Med J. 1974;2:666. CrossrefMedlineGoogle Scholar2. SellerKoch-Weser EJ. Displacement of warfarin from human albumin by diazoxide and thacrynic, wefenamic, and nalidixic acids. Clin Pharmacol Ther. 1970;11:524-9. CrossrefMedlineGoogle Scholar3. LeorLevartowskySharon JDC. Interaction between nalidixic acid and warfarin [Letter]. Ann Intern Med. 1987;107:601. LinkGoogle Scholar4. Physicians Desk Reference. 42 Ed. Oradell, NJ: Medical Economics Co., Inc.; 1988. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Latrobe Area Hospital Latrobe, PA 15650 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByQuinolonesQuinolonesCiprofloxacinThe safety of levofloxacin in elderly patients on warfarinMoxifloxacin—Warfarin Interaction: A Series of Five Case ReportsDrug Interactions Between Antibiotics and Select Maintenance Medications: Seeing More Clearly Through the Narrow Therapeutic Window of OpportunityThe interaction of moxifloxacin and warfarin in three elderly patientsAdverse Drug Reactions Related to the Use of Fluoroquinolone AntimicrobialsLevofloxacin and Warfarin InteractionINTERACTIONS OF WARFARINClinical PharmacologyManagement of Drug Interactions in Patients with HIVAbsence of an Effect of Levofloxacin on Warfarin Pharmacokinetics and Anticoagulation in Male VolunteersEffect of ciprofloxacin on the hypoprothrombinemic activity of warfarin in ratsUrinary Tract InfectionsOverview of fluoroquinolone safetyTemafloxacin: A safe antibiotic for the elderly, patients with comorbidities, and other special populationsCiprofloxacin interaction with sodium warfarin: A potentially dangerous side effectCiprofloxacin and warfarin interactionMeta-Analysis of Quinolone—Theophylline InteractionsCiprofloxacin and warfarin interactionNorfloxacin, the first of a new class of fluoroquinolone antimicrobials, revisitedMiscellaneous antibacterial and antiviral drugsPossible Interaction between Ciprofloxacin and WarfarinFluoroquinolone-drug interactions: An overviewDrug-drug interactions with ciprofloxacin and other fluoroquinolonesCiprofloxacin and WarfarinFrank E. Mott, MD, Sean Murphy, MD, Vernon Hunt, MD 1 May 1989Volume 110, Issue 9Page: 751-752KeywordsAntimicrobialsDrug synthesisDrugsFood and Drug Administration Issue Published: 1 May 1989 PDF DownloadLoading ...