Protein S, von Willebrand Factor, and Euglobulin Lysis Time as Markers of Coronary Heart Disease
Authors: Anthony Dart
Journal: Annals of Internal Medicine (1997)

Letters1 January 1997Protein S, von Willebrand Factor, and Euglobulin Lysis Time as Markers of Coronary Heart DiseaseAnthony Dart, BM, BCh, DPhil, Bridget Sherrard, BSc, and Hatem Salem, MBBS, FRACPAnthony Dart, BM, BCh, DPhilBaker Medical Research Institute; Prahran, Victoria, AustraliaBox Hill, Melbourne, AustraliaSearch for more papers by this author, Bridget Sherrard, BScBaker Medical Research Institute; Prahran, Victoria, AustraliaBox Hill, Melbourne, AustraliaSearch for more papers by this author, and Hatem Salem, MBBS, FRACPBaker Medical Research Institute; Prahran, Victoria, AustraliaBox Hill, Melbourne, AustraliaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-1-199701010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Considerable evidence has recently emerged to indicate a change in endothelial-dependent dilatation in patients with coronary disease or coronary risk factors [1]. It is less clear whether the release of endothelially derived hemostatic and fibrinolytic factors is also impaired. Endothelial cells are the major source of von Willebrand factor and protein S. The euglobulin lysis time is a global assessment of the fibrinolytic system and reflects the balance of tissue plasminogen activator and its inhibitor, plasminogen activator inhibitor I. Both proteins are exclusively synthesized by endothelial cells.Fifty-five patients (62% men; mean age ± SE, 62.5 ± ...References1. Yasue H, Matsuyama K, Okumura K, Morikami Y, Ogawa H. Responses of angiographically normal human coronary arteries to intra-coronary injection of acetylcholine by age and segment. Possible role of early atherosclerosis. Circulation. 1990; 81:482-90. Google Scholar2. Tsuchida A, Salem H, Thomson N, Hancock W. Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression. J Exp Med. 1992; 175:81-90. Google Scholar3. McFarlane DE, Stibbe J, Kirkby EP, Zucker MB, Grant RA, McPherson JA. A method for assaying von Willebrand factor (Ristocetin co-factor). Diathesis Haemorrhogica. 1975; 34:306-7. Google Scholar4. Robertson BR, Pandolf M, Nilsson IM. Fibrinolytic capacity in healthy volunteers as estimated from the effect of venous occlusion of arms. Acta Chirugica. 1972; 138:429. Google Scholar Author, Article, and Disclosure InformationAffiliations: Baker Medical Research Institute; Prahran, Victoria, AustraliaBox Hill, Melbourne, Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRelationships between protein C, protein S, von Willebrand factor and euglobulin lysis time and cardiovascular risk factors in subjects with and without coronary heart disease 1 January 1997Volume 126, Issue 1Page: 89KeywordsAnginaCoronary heart diseaseEndothelial cellsExercisePlasma proteinsProteinsQuestionnairesTissue plasminogen activatorVeinsvon Willebrand disease Issue Published: 1 January 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...