tbuckley/cabot-search huggingface dataset:
Allergic reaction to intralesional Celestone CronodoseR
Authors: A. Miguelez, F. Mestre, A. Martin, J. Escalas, L.J. Del Pozo
Journal: British Journal of Dermatology (2003)

Journal Article Allergic reaction to intralesional Celestone Cronodose® Get access A. Miguélez, A. Miguélez Section of Dermatology, Hospital Universitario Son Dureta, Avda. Andrea Doria 55, 07014 Palma de Mallorca, Spain E‐mail: anami@altern.org Search for other works by this author on: Oxford Academic Google Scholar F. Mestre, F. Mestre Section of Dermatology, Hospital Universitario Son Dureta, Avda. Andrea Doria 55, 07014 Palma de Mallorca, Spain E‐mail: anami@altern.org Search for other works by this author on: Oxford Academic Google Scholar A. Martín, A. Martín Section of Dermatology, Hospital Universitario Son Dureta, Avda. Andrea Doria 55, 07014 Palma de Mallorca, Spain E‐mail: anami@altern.org Search for other works by this author on: Oxford Academic Google Scholar J. Escalas, J. Escalas Section of Dermatology, Hospital Universitario Son Dureta, Avda. Andrea Doria 55, 07014 Palma de Mallorca, Spain E‐mail: anami@altern.org Search for other works by this author on: Oxford Academic Google Scholar L.J. Del Pozo L.J. Del Pozo Section of Dermatology, Hospital Universitario Son Dureta, Avda. Andrea Doria 55, 07014 Palma de Mallorca, Spain E‐mail: anami@altern.org Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 4, 1 October 2003, Pages 894–896, https://doi.org/10.1046/j.1365-2133.2003.05569.x Published: 01 October 2003
The editor's decision is final
Authors: L. Crossan, R. Smith
Journal: BMJ (1997)

Last year the BMJ received about 3850 letters for publication. We had space to publish about 1200 in the paper journal. We cannot increase the number of pages we devote to letters for two reasons—readers do not want us to and we could not afford to do so. We give priority to letters offering cogent criticisms of material we have …
Clinical Gynecologic Endocrinology and Infertility
Authors: Julian T. Archie
Journal: JAMA (1974)

The objectives of this text are two-fold—first, to demonstrate that reproductive endocrinology has become a clinical science based on physiology, and second, to provide a formulation of clinical diagnosis and management founded on physiologic principles. There are four sections: physiology of female reproduction, clinical endocrinology, infertility, and clinical assays. The manner of presentation is concise and clear with the aid of excellent, bold illustrations in the form of structural formulas, charts, and graphs. The first section is a foundation on which the second and third sections are dependent. The generally tedious presentation of normal physiology is made much more palatable by the authors' skill of presentation. The physiology of human reproduction comprises three chapters—hormonal biosynthesis, metabolism and mechanism of action, neuroendocrinology and regulation of the menstrual cycle. As the authors state, to begin a clinical book with a chapter on biochemistry only emphasizes that competent clinical judgment is founded on
Localization of In-111 White Blood Cells in Rhabdomyolysis
Authors: Partha Sinha, Gary R. Conrad, Shyamashree Sinha
Journal: Clinical Nuclear Medicine (2004)

Indium-111 labeled autologous white blood cells (In-111 WBCs) are commonly used for the detection and localization of bone and soft tissue infections. This report describes a patient having In-111 WBC uptake associated with rhabdomyolysis.
Hepatitis C virus antibody positive blood donors.
Authors: D Mutimer, J Shaw, R Harrison, F Ala, J Neuberger, E Elias
Journal: Gut (1993)

In an analysis of 15 blood donors referred from the Blood Transfusion Service to the Queen Elizabeth Hospital, Birmingham, more than 50% of anti-hepatitis C virus (HCV) positive patients had a parenteral risk factor. Most were serum HCV-RNA positive, and all were liver HCV-RNA positive. Although no physical signs of liver disease were apparent, all anti-HCV positive donors had abnormal liver histology.
Intrapericardial Cyst Formation in Constrictive Pericarditis Simulating Tricuspid Stenosis
Authors: AUBREY PITT, ROBERT H. CUTFORTH, HARVEY W. BENDER, J. O'NEAL HUMPHRIES, GEORGE R. STIRLING, J. MICHAEL CRILEY, RICHARD S. ROSS
Journal: Circulation (1969)

Two cases of constrictive pericarditis with intrapericardial cyst formation are presented. In each, a tricuspid diastolic murmur was present, and confirmation of a tricuspid valve gradient was obtained at cardiac catheterization. Angiographic studies revealed that the tricuspid valves were distorted by the cysts. In both patients, surgical excision was successfully achieved. In case 1 a blood-containing cyst was found, the etiology of which is obscure. Case 2 was associated with rheumatoid arthritis, and the compression resulted from a chronic abscess that probably arose at a previous pericardiectomy.
Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 1. Morphology and inhibition of fibrogenesis by dipyridamole
Authors: I R Wanless, J Belgiorno, P Huet
Journal: Hepatology (1996)

This study documents the hepatic morphology and the ultrastructure of a model of hepatic fibrosis in rabbits. Rabbits were given a cholesterol– supplemented diet (1%), a stilbestrol diet (10 mg subcutaneously twice a week), or both treatments simultaneously for 7 weeks. Rabbits given the combined treatment developed sinusoidal and portal fibrosis with only a mild disturbance of acinar vascular relationships. Ultrastructurally, there was marked widening of the spaces of Disse by collagen fibers, basement membrane material adjacent to endothelial cells and hepatocytes, blunted hepatocellular microvilli, activated stellate cells, lipid droplets in endothelial cells and hepatocytes, and degranulated platelets in sinusoids. The hepatic hydroxyproline content was markedly increased (12.0 ± 5.2 vs. 4.8 ± 1.5 mmol/g of liver dry weight; P &lt; .001). Plasma bile acids were markedly increased (222 ± 180 vs. 12 ± 5 in controls; P &lt; .001). Dipyridamole (25 mg every 12 hours) that was given in addition to cholesterol and stilbestrol decreased the hepatic collagen content (–49% and –48%, in two experiments; P &lt; .05 in both) and splenomegaly. This model provides a reliable method for the production of extensive sinusoidal fibrosis with capillarization of sinusoids. Hepatocellular degeneration is only mild to moderate, and fibrosis occurs slowly without the sudden pathological changes that occur with other models of hepatic fibrosis, such as with the administration of CCl4 or galactosamine. The mechanism of injury may involve the accumulation of bile salts or the generation of free radicals from cholesterol oxidation products. The possibility that the sinusoidal release of platelet–derived factors may have a role in the activation of stellate cells (lipocytes) is supported by the suppression of fibrogenesis by dipyridamole.
Smoking cessation strategies
Authors: S. Chapman, M. Wakefield
Journal: BMJ (2012)

Time to be more realistic in our expectations of interventions to help quitters 

Telephone lines devoted to supporting smoking cessation (quitlines) hold great promise because they are relatively inexpensive and highly accessible.1 Busy doctors who lack confidence in dealing with seemingly intractable smoking might be relieved to refer their patients to these specialised services, which are increasingly available worldwide. It is not clear, however, that they deliver the expected outcomes. In the linked randomised controlled trial (doi:10.1136/bmj.e1696), Ferguson and colleagues compare standard quitline support plus both free nicotine replacement therapy (NRT) and six follow-up calls with standard quitline support alone.2 Importantly, this trial was conducted in England, where NRT is already free to smokers trying to quit. In addition to providing information about the effect of making the pathway for receiving NRT even more unimpeded than it already is, the study’s findings help to answer two central questions about assisted smoking cessation.

Firstly, what proportion of smokers wanting to quit are interested in receiving support and medication in an environment where NRT is already provided free via doctors? Researchers in this field often note that many smokers do not use the treatment …
The Trauma of War: Stress and Recovery in Viet Nam Veterans
Authors: Robert A. Karp
Journal: JAMA (1986)

<h3>Post-traumatic Stress Disorder and the War Veteran Patient,</h3> edited by William E. Kelly (<i>Brunner/Mazel Psychosocial Stress Series</i>No. 5, Charles R. Figley, ed, institute, Coatesville, Pa, 1982), 338 pp, $30, New York, Brunner/Mazel Inc, 1985. <h3>Vietnam in Remission,</h3> edited by James F. Veninga and Harry A. Wilmer (published for the Texas Committee for the Humanities and the Institute for the Humanities at Salado), 142 pp, with illus, $14.95, College Station, Texas A&amp;M University Press, 1985. Troubled Vietnam veterans often are diagnostic puzzles, taxing staff and creating serious disturbances on psychiatric wards. In the first decade-plus since the fall of Saigon, few mental health books have been published about treatment of the combat veteran. The first two books reviewed herein reflect significant advances linking research on posttraumatic stress disorder (PTSD) and specific treatment modalities. Contributors to<i>The Trauma of War</i>suggest that clinicians examine their unwillingness to consider the diagnosis of
Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus–infected lipoatrophic men treated with pioglitazone: a pilot study
Authors: Faidon Magkos, Aoife Brennan, Laura Sweeney, Eun Seok Kang, John Doweiko, Adolf W. Karchmer, Christos S. Mantzoros
Journal: Metabolism (2010)
In Loco Parentis — Or Reducing Hazards for Hospital Patients
Authors: Lendon Snedeker
Journal: New England Journal of Medicine (1963)

ALL patients to some degree are children. Every hospital is in some measure a parent. Childhood, whether first or second, sedation, anesthesia and the mental confusion inherent in many pathologic states can all produce varying degrees of irresponsibility with which a hospital must be prepared to cope. This custodial function is built into the functioning structure of the hospital and necessitates written permission1 not only for specific operative procedures but for unforeseen contingencies as well. The patient formally cedes to others some of his rights of self-determination.Children create special custodial problems. They express their wants in action rather than . . .
Pleuroperitoneal Communication in a Patient with Right Pleural Effusion and Ascites Diagnosed by Technetium-99m Sulfur Colloid Imaging
Authors: B EISENBERG, M G VELCHIK, A. ALAVI
Journal: Clinical Nuclear Medicine (1988)

A 55-year-old man with an 11-year history of intermittent right pleural effusions had continued fevers and a large right transudative pleural effusion. Minimal ascites was noted by ultrasound examination. A communication between the thorax and intraperitoneal cavity was established by radionuclide examination of the chest and abdomen. Tc-99m sulfur colloid was injected into the peritoneal cavity, and imaging at 1 and 4.5 hours confirmed passage from the peritoneal to the pleural cavity. Repeated attempts to sclerose the pleural cavity failed to decrease the transudative accumulations. The patient was subsequently treated with the placement of a LeVeen shunt.
Comparision of Papillary Muscle Deformation Parameters in Patients with Hypertrophic Cardiomyopathy and Hypertension
Authors: Atilla Koyuncu, Gokhan Kahveci, Alev Kilicgedik, Cuneyt Toprak, Ruken Bengi Bakal, Goksel Acar, Anil Avci, Muhammet Tellice, Yeliz Guler, Gokhan Alici, Birol Ozkan, Selcuk Pala, Ali Metin Esen
Journal: Journal of the American College of Cardiology (2013)
Fluorouracil, Mitomycin, and Radiotherapy vs Fluorouracil, Cisplatin, and Radiotherapy for Carcinoma of the Anal Canal
Authors: Jaffer A. Ajani
Journal: JAMA (2008)

Chemoradiation as definitive therapy is the preferred primary therapy for patients with anal canal carcinoma; however, the 5-year disease-free survival rate from concurrent fluorouracil/mitomycin and radiation is only approximately 65%.To compare the efficacy of cisplatin-based (experimental) therapy vs mitomycin-based (standard) therapy in treatment of anal canal carcinoma.US Gastrointestinal Intergroup trial RTOG 98-11, a multicenter, phase 3, randomized controlled trial comparing treatment with fluorouracil plus mitomycin and radiotherapy vs treatment with fluorouracil plus cisplatin and radiotherapy in 682 patients with anal canal carcinoma enrolled between October 31, 1998, and June 27, 2005. Stratifications included sex, clinical nodal status, and tumor diameter.Participants were randomly assigned to 1 of 2 intervention groups: (1) the mitomycin-based group (n = 341), who received fluorouracil (1000 mg/m2 on days 1-4 and 29-32) plus mitomycin (10 mg/m2 on days 1 and 29) and radiotherapy (45-59 Gy) or (2) the cisplatin-based group (n = 341), who received fluorouracil (1000 mg/m2 on days 1-4, 29-32, 57-60, and 85-88) plus cisplatin (75 mg/m2 on days 1, 29, 57, and 85) and radiotherapy (45-59 Gy; start day = day 57).The primary end point was 5-year disease-free survival; secondary end points were overall survival and time to relapse.A total of 644 patients were assessable. The median follow-up for all patients was 2.51 years. Median age was 55 years, 69% were women, 27% had a tumor diameter greater than 5 cm, and 26% had clinically positive nodes. The 5-year disease-free survival rate was 60% (95% confidence interval [CI], 53%-67%) in the mitomycin-based group and 54% (95% CI, 46%-60%) in the cisplatin-based group (P = .17). The 5-year overall survival rate was 75% (95% CI, 67%-81%) in the mitomycin-based group and 70% (95% CI, 63%-76%) in the cisplatin-based group (P = .10). The 5-year local-regional recurrence and distant metastasis rates were 25% (95% CI, 20%-30%) and 15% (95% CI, 10%-20%), respectively, for mitomycin-based treatment and 33% (95% CI, 27%-40%) and 19% (95% CI, 14%-24%), respectively, for cisplatin-based treatment. The cumulative rate of colostomy was significantly better for mitomycin-based than cisplatin-based treatment (10% vs 19%; P = .02). Severe hematologic toxicity was worse with mitomycin-based treatment (P < .001).In this population of patients with anal canal carcinoma, cisplatin-based therapy failed to improve disease-free-survival compared with mitomycin-based therapy, but cisplatin-based therapy resulted in a significantly worse colostomy rate. These findings do not support the use of cisplatin in place of mitomycin in combination with fluorouracil and radiotherapy in the treatment of anal canal carcinoma.clinicaltrials.gov Identifier: NCT00003596.
Philosophical Chemistry in the Scottish Enlightenment: The Doctrines and Discoveries of William Cullen and Joseph Black
Authors: Lester S. King
Journal: JAMA (1976)

In Arthur Donovan's excellent book, the major focus is on the history of chemistry in 18th century Scotland, but the volume involves the entire intellectual life of the era. In the 18th century, Scotland led the world in medical education. It produced philosophers of the highest rank like David Hume, Francis Hutcheson, and Adam Smith; physicians like the two central figures of this book, William Cullen and Joseph Black, important in both medicine and in chemistry; and a host of lesser figures. In his exposition, Donovan first draws a picture of the cultural and intellectual milieu, with special reference to so-called "natural philosophy," as well as the currents and countercurrents of university life and medical education. Then he gives an account of the state of chemistry, with special reference to the place of Cullen as a teacher and a theorist. This is an illuminating account of the history of chemistry
Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.
Authors: C I Bindon, G Hale, M Brüggemann, H Waldmann
Journal: The Journal of Experimental Medicine (1988)

Humanized antibodies are likely to have a major role in therapy and it is important to define their interaction with physiological effectors. By comparing a matched series of chimeric human mAbs we found that igG1 was most efficient in complement lysis, although IgG3 bound more C1q. To resolve this paradox we compared the ability of human IgG1, IgG2, IgG3, IgG4, and IgE and rat IgG2b to cause C1q binding, C1 binding and activation, C4 activation, C4b binding, and C3b binding. Rat IgG2b was included because this isotype has already successfully been used for therapy. Human IgG1 was less efficient than IgG3 and fixing C1q and C1 on the cell surface, but the number of C4 molecules bound per C1 was 10-fold greater for IgG1 than for IgG3. This difference, amplified through later stages of the complement cascade, can account for the superiority of IgG1 for cell lysis. The efficiency of IgG1 in fixing C4 was not due to a favored binding site on the antibody molecule, since virtually all of the bound C4b was attached to the cells. Rather, it appeared that the activation of C4 by C1s was greatly favored by IgG1 compared with IgG3. It should be possible to combine the optimal properties of IgG1 and IgG3 antibodies to produce an improved therapeutic reagent.
Scan-demonstrated ilioportal shunt with resolution.
Authors: P G Bentley, P L Hill
Journal: BMJ (1978)

reported by Professor Morris and his colleagues with high fibre intake (and lower incidence of ischaemic heart disease) would obtain 200mg magnesium per week more than the low-fibre group from their brown bread alone, and this is 5-100% of the weekly total required to stay in magnesium balance.4It may be the metal content of brown bread rather than the fibre which protects the consumer from ischaemic heart disease.The data collected by Professor Morris and his colleagues could be used to estimate the weights of magnesium, potassium, and iron consumed by their subjects, and this would be worth further investigation.
Unrecognized Diabetes Among Hospitalized Patients
Authors: Claresa S Levetan, Maureen Passaro, Kathleen Jablonski, Mary Kass, Robert E Ratner
Journal: Diabetes Care (1998)

To evaluate the hospital care rendered to hyperglycemic individuals who did not have a diagnosis of diabetes before admission.A total of 1,034 consecutively hospitalized adult patients at a 750-bed inner-city teaching hospital were evaluated. Patients with one or more plasma glucose values > 200 mg/dl were identified by the laboratory data system on a daily basis. Patients without a diagnosis of diabetes at the time of admission were evaluated to determine if and how physicians addressed the hyperglycemia, whether a new diagnosis of diabetes was made during admission, and whether follow-up was planned to address the hyperglycemia.After excluding patients who were admitted for a primary diagnosis of diabetes, 37.5% of all hyperglycemic medical patients and 33% of hyperglycemic surgical patients were without a diagnosis of diabetes at the time of admission. These patients had a mean peak glucose of 299 mg/dl, and 66% had two or more elevated values during their hospitalization. Fifty-four percent received insulin therapy, and 59% received bedside glucose monitoring, yet 66% of daily patient progress notes failed to comment on the presence of hyperglycemia or diabetes. Diabetes was documented in only three patients (7.3%) as a possible diagnosis in the daily progress notes.Despite marked hyperglycemia, most medical records made no reference to the possibility of unrecognized diabetes. Given the average delay of a decade between the onset and diagnosis of type 2 diabetes, further evaluation of hyperglycemic hospitalized patients may present an important opportunity for earlier detection and the initiation of therapy.
Epidemiology and Prevention of Breast Cancer
Authors: Jennifer L. Kelsey, Leslie Bernstein
Journal: Annual Review of Public Health (1996)

Breast cancer is the most common cancer in women, accounting for 32% of all newly diagnosed cancers. Demographic characteristics associated with an increased risk include increasing age, birth in North America or northern Europe, high socioeconomic status, never having been married, and, for breast cancer diagnosed after 45 years of age, the white race. Early age at menarche, late age at menopause, late age at first full-term pregnancy, and low parity increase risk, while removal of the ovaries at an early age is protective. Obesity increases risk in postmenopausal women. Having a first degree relative with breast cancer confers an increased risk, especially if both a mother and a sister have had breast cancer at an early age. Mutations in the BRCAl and BRCA2 genes are associated with an inherited susceptibility to breast cancer at an early age. Other markers of increased risk include atypical and hyperplastic epithelial cells in nipple aspirate fluid, nodular densities on mammogram, and biopsy-confirmed benign proliferative breast disease. Little can be done at present to reduce breast cancer risk through primary prevention, but secondary prevention by mammographic screening in women of age 50 and older reduces mortality from breast cancer.
How Effective Will National Health Insurance Be?
Authors: OSLER L. PETERSON
Journal: Annals of Internal Medicine (1973)

Discussions of national health insurance for the population of the United States are increasing. The problems of the medical care system, which have led to these proposals, are discussed, and the possible effects of the principal legislative plans are analyzed. These effects range from further inflation of medical care prices to solutions for some of the more serious problems. All the proposed legislation would provide medical care insurance but not health insurance; the latter would require far broader social action than is called for in any of these plans.
Childhood Brain Tumors, Residential Insecticide Exposure, and Pesticide Metabolism Genes
Authors: Susan Searles Nielsen, Roberta McKean-Cowdin, Federico M. Farin, Elizabeth A. Holly, Susan Preston-Martin, Beth A. Mueller
Journal: Environmental Health Perspectives (2009)

Insecticides that target the nervous system may play a role in the development of childhood brain tumors (CBTs). Constitutive genetic variation affects metabolism of these chemicals.We analyzed population-based case-control data to examine whether CBT is associated with the functional genetic polymorphisms PON1C-108T, PON1Q192R, PON1L55M, BCHEA539T, FMO1C-9536A, FMO3E158K, ALDH3A1S134A, and GSTT1 (null). DNA was obtained from newborn screening archives for 201 cases and 285 controls, <or= 10 years of age, and born in California or Washington State between 1978 and 1990. Conception-to-diagnosis home insecticide treatment history was ascertained by interview.We observed no biologically plausible main effects for any of the metabolic polymorphisms with CBT risk. However, we observed strong interactions between genotype and insecticide exposure during childhood. Among exposed children, CBT risk increased per PON1-108T allele [odds ratio (OR) = 1.8; 95% confidence interval (CI), 1.1-3.0] and FMO1-9536A (*6) allele (OR = 2.7; 95% CI, 1.2-5.9), whereas among children never exposed, CBT risk was not increased (PON1: OR = 0.7; 95% CI, 0.5-1.0, interaction p = 0.005; FMO1: OR = 1.0; 95% CI, 0.6-1.6, interaction p = 0.009). We observed a similar but statistically nonsignificant interaction between childhood exposure and BCHEA539T (interaction p = 0.08). These interactions were present among both Hispanic and non-Hispanic white children.Based on known effects of these variants, these results suggest that exposure in childhood to organophosphorus and perhaps to carbamate insecticides in combination with a reduced ability to detoxify them may be associated with CBT. Confirmation in other studies is required.