Acquired Factor XIII Deficiency with Chronic Myelomonocytic Leukemia
Authors: Michelle Petri, Leonard Ellman, Robert Carey
Journal: Annals of Internal Medicine (1983)

Brief Reports1 November 1983Acquired Factor XIII Deficiency with Chronic Myelomonocytic LeukemiaMICHELLE PETRI, M.D., LEONARD ELLMAN, M.D., ROBERT CAREY, M.D.MICHELLE PETRI, M.D.Search for more papers by this author, LEONARD ELLMAN, M.D.Search for more papers by this author, ROBERT CAREY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-5-638 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcquired factor XIII deficiency is a rare disorder that leads to spontaneous bleeding and large hematomas. Most cases have occurred in the setting of isoniazid therapy. We report a case of acquired factor XIII deficiency in the setting of chronic myelomonocytic leukemia.An 80-year-old white woman was admitted to the hospital in June 1981 with symptoms of fatigue and weight loss. The spleen was palpable on inspiration. The hematocrit was 36%, the leukocyte count was 73 000/mm3with a differential of 56% polymorphonuclear leucocytes, 5% bands, 6% lymphocytes, 21% monocytes, 1% eosinophil, 1% basophils, 15% blast forms, 1% myelocytes and...References1. LAKILORAND KL. On solubility of fibrin clots. Science. 1948;108:280. CrossrefMedlineGoogle Scholar2. MIESCHERFARQUET PJ. Chronic myelomonocytic leukemia in adults. Semin Hematol. 1974;11:129-39. MedlineGoogle Scholar3. LORANDLOSOWSKYMILOSZEWSKI LMK. Human factors XIII: fibrin-stabilizing factor. Prog Hemost Thromb. 1980;50:245-90. Google Scholar4. MANDELGERHOLD EW. Plasma fibrin-stabilizing factor: acquired deficiency in various disorders. Am J Clin Pathol. 1969;52:547-56. CrossrefMedlineGoogle Scholar5. NUSSBAUMMORSE MB. Plasma fibrin-stabilizing activity in various diseases. Blood. 1964;23:669-78. CrossrefMedlineGoogle Scholar6. RASCHEDIETRICHGUASSCHLEYER HMWM. Factor XIII-activity and fibrin subunit structure in acute leukemia. Biomedicine. 21:61-6, 1974;21:61-6. MedlineGoogle Scholar7. HAVEMANNEGBRINGGROPPSCHMIDTSOLOMAN KRCMC. Factor XIII deficiency in adults with acute leukemia: results of a substitution therapy with factor XIII. Klin Wochenscher. 1977;55:801-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntiplatelet Drugs in the Management of Cerebral IschemiaA child with acquired factor XIII deficiency: case report and literature reviewCentral Nervous System IschemiaAcquired factor XIII deficiency: a therapeutic challengePostoperative Bleeding in a Patient With Normal Screening Coagulation TestsCentral Nervous System IschemiaHematologic Causes of Intracerebral Hemorrhage and Their TreatmentHemostasis in malignancy 1 November 1983Volume 99, Issue 5Page: 638-639KeywordsEosinophilsFatigueHematocritHemorrhageIsoniazidLymphocytesMonocytesMyelomonocytic leukemiaSpleenWeight loss Issue Published: 1 November 1983 PDF downloadLoading ...