tbuckley/cabot-search huggingface dataset:
The Bioactivity of Cartilage Extracellular Matrix in Articular Cartilage Regeneration
Authors: Amanda J. Sutherland, Gabriel L. Converse, Richard A. Hopkins, Michael S. Detamore
Journal: Advanced Healthcare Materials (2014)

Cartilage matrix is a promising material for cartilage regeneration given the evidence supporting its chondroinductive character. The "raw materials" of cartilage matrix can serve as building blocks and signals for tissue regeneration. These matrices can be created by chemical or physical processing: physical methods disrupt cellular membranes and nuclei but may not fully remove all cell components and DNA, whereas chemical methods combined with physical methods are effective in fully decellularizing such materials. It is important to delineate between the sources of the cartilage matrix, that is, derived from matrix in vitro or from native tissue, and then to further characterize the cartilage matrix based on the processing method, decellularization or devitalization. With these distinctions, four types of cartilage matrices exist: decellularized native cartilage (DCC), devitalized native cartilage (DVC), decellularized cell-derived matrix (DCCM), and devitalized cell-derived matrix (DVCM). One currently marketed cartilage matrix device is decellularized, although trends in patents suggest additional decellularized products may be available in the future. To identify the most relevant source and processing for cartilage matrix, testing needs to include targeting the desired application, optimizing delivery of the material, identify relevant FDA regulations, assess availability of materials, and immunogenic properties of the product.
The Clinical Expression of Magnesium Deficiency
Authors: William O. Smith
Journal: JAMA (1960)

Hirschfelder<sup>1</sup>first described clinical symptoms in man resulting from a deficiency of magnesium in 1934. Twenty years later Flink<sup>2</sup>confirmed that neuromuscular hyperirritability may result from magnesium want and reported that such patients may also develop hallucinations. These findings have subsequently been confirmed by other investigators.<sup>3</sup>During the past five years we have observed 18 patients with the magnesium deficiency syndrome other than alcoholic delirium tremens, some of whom showed clinical findings not heretofore described. In addition, some of the predisposing medical conditions leading to the magnesium deficiency in this group of patients have not previously been stressed. The clinical picture of magnesium deficiency is principally characterized by neuromuscular and central nervous system hyperirritability, although cardiovascular disturbances may be observed. A tremor is seen in most of the patients (table 1) which consists of athetoid or choreiform movements. The tremor may be accentuated by asking the patient
Pacing-Induced Increase in QT Dispersion Predicts Sudden Cardiac Death Following Cardiac Resynchronization Therapy
Authors: Shajil Chalil, Zaheer R. Yousef, Sarkaw A. Muyhaldeen, Russell E. A. Smith, Paul Jordan, Christopher R. Gibbs, Francisco Leyva
Journal: Journal of the American College of Cardiology (2006)
Shared circuits, shared time, and interpersonal synchrony
Authors: Michael J. Hove
Journal: Behavioral and Brain Sciences (2008)

Abstract The shared circuits model (SCM) is a useful explanatory framework that can be applied to interpersonal synchrony by incorporating temporal dynamics. Temporally precise predictive simulations and mirroring enable interpersonal synchrony. When partners' movements are highly synchronous, the self/other distinction can be blurred.
Increased frequency of neonatal jaundice in a maternity hospital.
Authors: N Campbell, D Harvey, A P Norman
Journal: BMJ (1975)

The frequency of "significant" jaundice of the newborn at this hospital increased from 8-1% of all live births in 1971 to 12-1% in 1972 and 15-4% in 1973. This coincided with an increased use of oxytocic agents and epidural anaesthetics in labour, and a change in the artificial feed given to normal infants. A retrospective study of jaundiced infants born in 1972 failed to explain the increase in jaundice. Though the use of oxytocic agents was not the direct cause, since their use results in the delivery of more infants before 40 weeks of gestation it may be a contributory factor. The use of epidural anaesthetics was sastically related to the development of jaundice but the nature of the association was not clear. Mothers of infants who became jaundiced has a significantly higher frequency of poor past obstetric histories, but once again the association was not clear. The change in artificial feeds was excluded as a possible cause.
Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy
Authors: Margarete Focke-Tejkl, Milena Weber, Katarzyna Niespodziana, Angela Neubauer, Hans Huber, Rainer Henning, Gottfried Stegfellner, Bernhard Maderegger, Martina Hauer, Frank Stolz, Verena Niederberger, Katharina Marth, Julia Eckl-Dorna, Richard Weiss, Josef Thalhamer, Katharina Blatt, Peter Valent, Rudolf Valenta
Journal: Journal of Allergy and Clinical Immunology (2014)

Grass pollen is one of the most important sources of respiratory allergies worldwide.This study describes the development of a grass pollen allergy vaccine based on recombinant hypoallergenic derivatives of the major timothy grass pollen allergens Phl p 1, Phl p 2, Phl p 5, and Phl p 6 by using a peptide-carrier approach.Fusion proteins consisting of nonallergenic peptides from the 4 major timothy grass pollen allergens and the PreS protein from hepatitis B virus as a carrier were expressed in Escherichia coli and purified by means of chromatography. Recombinant PreS fusion proteins were tested for allergenic activity and T-cell activation by means of IgE serology, basophil activation testing, T-cell proliferation assays, and xMAP Luminex technology in patients with grass pollen allergy. Rabbits were immunized with PreS fusion proteins to characterize their immunogenicity.Ten hypoallergenic PreS fusion proteins were constructed, expressed, and purified. According to immunogenicity and induction of allergen-specific blocking IgG antibodies, 4 hypoallergenic fusion proteins (BM321, BM322, BM325, and BM326) representing Phl p 1, Phl p 2, Phl p 5, and Phl p 6 were included as components in the vaccine termed BM32. BM321, BM322, BM325, and BM326 showed almost completely abolished allergenic activity and induced significantly reduced T-cell proliferation and release of proinflammatory cytokines in patients' PBMCs compared with grass pollen allergens. On immunization, they induced allergen-specific IgG antibodies, which inhibited patients' IgE binding to all 4 major allergens of grass pollen, as well as allergen-induced basophil activation.A recombinant hypoallergenic grass pollen allergy vaccine (BM32) consisting of 4 recombinant PreS-fused grass pollen allergen peptides was developed for safe immunotherapy of grass pollen allergy.
[782] HBV-SPECIFIC HLA-DRB1*0101 TETRAMERS FOR SENSITIVE DETECTION AND ANALYSIS OF HEPATITIS B VIRUS SPECIFIC CD4+ T-LYMPHOCYTES
Authors: M.H.J. Heeg, A. Ulsenheimer, N.H. Gruner, H.M. Diepolder, W. Schraut, M. Wachtler, R. Zachoval, G.R. Pape, M.C. Jung
Journal: Journal of Hepatology (2007)
Reinfection of liver graft by hepatitis C virus after liver transplantation.
Authors: C Féray, D Samuel, V Thiers, M Gigou, F Pichon, A Bismuth, M Reynes, P Maisonneuve, H Bismuth, C Bréchot
Journal: Journal of Clinical Investigation (1992)

We have investigated hepatitis C virus (HCV) viremia before and after orthotopic liver transplantation (OLT). 38 patients were examined; 16 were anti-HCV positive and 22 anti-HCV negative pre-OLT in a RIBA-2 test (Ortho Diagnostic Systems Inc., Westwood, MA). HCV-RNA was detected using a modified nested polymerase chain reaction in 14/38 and 10/38 patients before and after OLT, respectively. 7 of these 14 subjects who were HCV-RNA positive before OLT were also positive for serum hepatitis B surface antigen. After OLT, six patients became HCV-RNA positive, likely as a result of transfusions, while four developed a probable recurrence of HCV infection. Infection of the liver graft by the same strain of HCV was indeed demonstrated by sequence analysis of a hypervariable domain (in the envelope region) in two cases. This establishes the possibility of HCV recurrence and shows the usefulness of polymerase chain reaction as the only assay currently capable of identifying HCV infection after OLT.
Inorganic dust pneumonias: the metal-related parenchymal disorders.
Authors: P Kelleher, K Pacheco, L S Newman
Journal: Environmental Health Perspectives (2000)

In recent years the greatest progress in our understanding of pneumoconioses, other than those produced by asbestos, silica, and coal, has been in the arena of metal-induced parenchymal lung disorders. Inhalation of metal dusts and fumes can induce a wide range of lung pathology, including airways disorders, cancer, and parenchymal diseases. The emphasis of this update is on parenchymal diseases caused by metal inhalation, including granulomatous disease, giant cell interstitial pneumonitis, chemical pneumonitis, and interstitial fibrosis, among others. The clinical characteristics, epidemiology, and pathogenesis of disorders arising from exposure to aluminum, beryllium, cadmium, cobalt, copper, iron, mercury, and nickel are presented in detail. Metal fume fever, an inhalation fever syndrome attributed to exposure to a number of metals, is also discussed. Advances in our knowledge of antigen-specific immunologic reactions in the lung are particularly evident in disorders secondary to beryllium and nickel exposure, where immunologic mechanisms have been well characterized. For example, current evidence suggests that beryllium acts as an antigen, or hapten, and is presented by antigen-presenting cells to CD4+ T cells, which possess specific surface antigen receptors. Other metals such as cadmium and mercury induce nonspecific damage, probably by initiating production of reactive oxygen species. Additionally, genetic susceptibility markers associated with increased risk have been identified in some metal-related diseases such as chronic beryllium disease and hard metal disease. Future research needs include development of biologic markers of metal-induced immunologic disease, detailed characterization of human exposure, examination of gene alleles that might confer risk, and association of exposure data with that of genetic susceptibility.
Intraoperative Neurophysiologic Monitoring
Authors: Kan Ding
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Precut sphincterotomy using insulated angulotome
Authors: P. Chiu, E. Ng, A. Teoh, S. Wong, J. Sung, J. Lau
Journal: Endoscopy (2010)

A newly designed insulated angulotome was evaluated in a series of patients in whom biliary cannulation using conventional methods had failed and who required precut sphincterotomy. The new device consists of an insulated glass tip to prevent excessive electrocautery flow, and angulation to facilitate elevation of the papillary roof on cutting. A prospective series of patients with cholangitis or obstructive jaundice with failed biliary cannulation were recruited. The success of cannulation and complications following endoscopic retrograde cholangiopancreatography were analyzed. A total of 13 patients underwent precut sphincterotomy using the insulated angulotome. The immediate success of gaining biliary access after failed cannulation was 100 %. The mean size of the common bile duct on ultrasonography was 8.1 mm. The mean time to achieve biliary cannulation was 9 minutes 4 seconds, and there was no perforation or bleeding. This case series showed that precut sphincterotomy with the insulated angulotome can be safely performed without major complications.
Increased Protein Nitration Burden in the Atherosclerotic Lesions and Plasma of Apolipoprotein A-I–Deficient Mice
Authors: Ioannis Parastatidis, Leonor Thomson, Diana M. Fries, Ryan E. Moore, Junichiro Tohyama, Xiaoming Fu, Stanley L. Hazen, Harry F.G. Heijnen, Michelle K. Dennehy, Daniel C. Liebler, Daniel J. Rader, Harry Ischiropoulos
Journal: Circulation Research (2007)

Apolipoprotein A-I (apoA-I), the major protein constituent within high-density lipoprotein (HDL), has been associated with antiatherogenic protection by mechanisms that include reverse cholesterol transport and antiinflammatory functions. To evaluate the proposed protective function of apoA-I, proteins modified by nitrating oxidants were evaluated in the aortic tissue and plasma of mice lacking the low-density lipoprotein receptor and apobec (LA) and LA mice with genetic deletion of apoA-I (LA-apoA-I(-/-)). The levels of nitrated proteins in aortic tissue quantified by liquid chromatography with online electrospray ionization tandem mass spectrometry (LC/ESI/MS/MS) were 6-fold higher in the LA-apoA-I(-/-) as compared with the LA mice. The quantitative analyses were corroborated by immunohistochemical and high-resolution immunoelectron microscopic evaluation of the lesions, which revealed abundant staining for nitrated proteins in the aortic root lesions of LA-apoA-I(-/-) as compared with the LA mice. Proteomic approaches based on affinity enrichment and site-specific adduct mapping identified unique specific protein targets for nitration in the plasma of LA-apoA-I(-/-) that were not present in the plasma of LA mice. In particular the nitration of fibrinogen was shown to accelerate fibrin clot formation. Another consequence of the augmented levels of nitrated proteins was the induction of humoral responses documented by the increased circulating immunoglobulins that recognize nitrotyrosine in LA-apoA-I(-/-) as compared with the LA mice. These data collectively support a protective function of apoA-I diminishing the burden of nitrative oxidants in these mice models of atherosclerosis.
The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns.
Authors: M Antikainen, S Murtomäki, M Syvänne, R Pahlman, E Tahvanainen, M Jauhiainen, M H Frick, C Ehnholm
Journal: Journal of Clinical Investigation (1996)

The human paraoxonase gene (HUMPONA) is codominantly expressed as alleles A and G. The A allele codes for glutamine (A genotype) and the G allele for arginine (B genotype) at position 191 of the paraoxonase enzyme. This genetic polymorphism has been suggested to be associated with the predisposition to coronary artery disease (CAD). We investigated the frequency of paraoxonase A and G alleles in 380 well-characterized CAD patients and in 169 controls. The most common genotype in both the patients with CAD (211/380) and in healthy Finnish individuals (87/169) was AA (Gln/Gln). The heterozygous AM (Gln/Arg) genotype was present in 140 of the patients and in 75 controls. The frequency of the A allele was 0.74 in both patients and controls. The genotype distribution between the two groups did not differ (P = 0.12, chi2 test). The genotype distributions were also similar to those reported earlier in other caucasoid populations. In conclusion, we found no association between the Gln-Arg 191 polymorphism of the human paraoxonase gene and coronary artery disease in Finns.
Motorneurons Require Cysteine String Protein-α to Maintain the Readily Releasable Vesicular Pool and Synaptic Vesicle Recycling
Authors: José Luis Rozas, Leonardo Gómez-Sánchez, Josif Mircheski, Pedro Linares-Clemente, José Luis Nieto-González, M. Eugenio Vázquez, Rafael Luján, Rafael Fernández-Chacón
Journal: Neuron (2012)
Articles criticising nevirapine trial may endanger babies' lives
Authors: DC Bob Roehr
Journal: BMJ (2005)

Three articles published by the Associated Press in mid-December criticising the conduct of a trial of the antiretroviral drug nevirapine in Uganda are threatening to undermine its use in newborn babies in developing countries, according to South African experts. A single dose of the drug given to mothers while in labour and to their babies at the time of birth is known to greatly reduce transmission of HIV from mother to child.

The articles, which appeared in newspapers and were broadcast on radio stations in the United States, Britain, South Africa, and many other countries, made allegations about a trial that was conducted from 1997 to 1999 in Uganda by researchers from Johns Hopkins University and Makerere University in Kampala, Uganda, and subsequently published.

The writer of the articles alleged that leaked documents showed that record keeping in the trial was shoddy, that single use of the drug led to resistance to it in patients …
Mosby's Medical Surfari: A Guide to Exploring the Internet and Discovering the Top Health Care Resources
Authors: Alan J. Bridges
Journal: JAMA (1997)

Internet The Internet is rapidly growing as a source of health-related information for patients, physicians, and other health care professionals. As persons interested in health care promotion and education realize the power of the computer and put its strengths to use, the Internet will become an important (and inexpensive) library of information. As recently noted by my colleague Dr Richard Friedman, there are a number of problems with using the World Wide Web as a source of medical education or information.<sup>1</sup>Although<i>Mosby's Medical Surfari</i>, a guide to exploring the Internet and discovering health care resources, cannot overcome the challenge of creating innovative, up-to-date, multimedia-based medical information, it does provide the user with a guide to how to best use the Internet for currently available health care resources. I found<i>Medical Surfari</i>to be an excellent resource for both the novice and more seasoned Internet user. For the beginner,
J. Goslings, Professor of Rheumatology, University of Leiden.
Authors: E G Bywaters
Journal: Annals of the Rheumatic Diseases (1975)

Hans Goslings, who died in October, will be deeply mourned, not only by his devoted family and his wide circle of friends and colleagues in Holland, but by those (particularly in England) who knew him throughout the world.Here in England he had a very special place in our hearts and will always be remem- bered by those ofus who had the privilege ofknowing him as a friend or teacher.Modest as he was, he towered as a giant-gigantic energy, gigantic enthusi- asm, and perhaps above all gigantic good humour and joie de vivre.Any gathering that included Hans and his wife Cor was a success.By history he will be remembered not only for his role in the East Indies and his work in the rebuilding of university medicine after the war,
Blood Pressure, Insulin, and C-Peplide Levels in San Luis Valley, Colorado
Authors: Nathan R Every, Edward J Boyko, Ellen M Keane, Julie A Marshall, Marian Rewers, Richard F Hamman
Journal: Diabetes Care (1993)

OBJECTIVE To explore the associations between blood pressure and both fasting insulin and C-pep tide levels. RESEARCH DESIGN AND METHODS A cross-sectional analysis was conducted of 895 normoglycemic members of a bi-ethnic community in Colorado who were selected from a control group recruited for a geographically based study of diabetes mellitus prevalence and risk factors. All subjects included in this study had normal glucose tolerance as judged by a 75-g oral glucose tolerance test interpreted using World Health Organization criteria. None of the subjects were taking antihypertensive medication. Multiple linear regression analysis was used to examine relationships between fasting insulin and C-peptide levels and blood pressure. RESULTS Among all subjects, diastolic blood pressure was found to significantly increase with increasing levels of both hormones (insulin coefficient = 0.197, P = 0.013; C-peptide coefficient = 0.0436, P = 0.004), whereas systolic blood pressure was significantly related to fasting C-peptide level (coefficient = 0.0295, P = 0.050). These relationships were similar in magnitude for both Hispanic and non-Hispanic white subjects, but were diminished among women and subjects with a higher body mass index. CONCLUSIONS Higher fasting insulin and C-peptide levels are associated with higher blood pressure, but these relationships are modified by sex and degree of obesity.
Bacillus cereus: Not a Contaminant
Authors: Carl Perlino
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Coincident with the publication of the article by Tuazon et al (241:1137, 1979), I participated in the care of a patient with pneumonia and empyema due to<i>Bacillus cereus</i>. The case is described here to emphasize that this Gram-positive bacillus should not be dismissed as a bacteriologic contaminant of clinical specimens. Also, apparently appropriate antimicrobial therapy as determined by disk sensitivity may not be adequate in predicting response. <h3>Report of a Case.—</h3> A 50-year-old man with chronic active hepatitis and cirrhosis was hospitalized with two days of fever, dyspnea, and left-sided pleuritic chest pain. One month previously, he had been hospitalized with chills, hemoptysis, and bilateral lower lobe pulmonary infiltrates, thought to be consistent with pulmonary emboli. An episode of gastroenteritis followed. On admission, temperature was 38.6 °C; respirations were 35/min. Spider angioma, palmar erythema, and ascites were present. Examination of the chest disclosed rales, rhonchi,
Oral Contraceptives and Cervical Cancer-Reply
Authors: Kathleen L. Irwin
Journal: JAMA (1988)

<h3>In Reply.</h3> —Dr Celentano correctly points out that the negative associations found in our case-control study of oral contraceptives and invasive cervical cancer in Costa Rica and in his study in inner-city Baltimore<sup>1</sup>may reflect detection bias, rather than a truly protective effect. If oral contraceptive users are more likely to receive cervical smears than nonusers, they are more likely to be identified as having the disease before the invasive stage of cervical cancer and then to receive treatment. Thus, oral contraceptive users may be under-represented among cases of invasive cervical cancer, resulting in a spurious negative association. A lifetime history of one or more cervical smears is more common in the United States than in Costa Rica.<sup>2</sup>Despite the overall higher screening prevalence in the United States, Celentano et al reported that the enhanced screening of oral contraceptive users we found in Costa Rica also occurs in