tbuckley/cabot-search huggingface dataset:
STUDIES OF LEPTOSPIRA HEBDOMADIS
Authors: M. Koshina, S. Shiozawa, K. Kitayama
Journal: The Journal of Experimental Medicine (1925)

From the results of etiological study of the disease known as akiyami which prevails in the Shida district of Shizuoka province, we conclude that: 1. Akiyami is an infectious disease caused by a leptospira. 2. The leptospira causing akiyami is very difficult to differentiate morphologically from Leptospira icterohoemorrhagioe and Leptospira hebdomadis. 3. The strains of leptospira isolated from cases of akiyami are of two types. One type, isolated from three of the sixteen cases, is highly virulent for guinea pigs and is serologically distinct from Leptospira icterohoemorrhagioe and Leptospira hebdomadis; we have called this the A type. The type obtained from the other cases is less virulent for guinea pigs and is serologically identical with Leptospira hebdomadis; we have called this the B type. 4. The field mouse (Microtus montebelli), which harbors Leptospira hebdomadis, has also been found to harbor the A type of akiyami.
900 RECOMBINANT LYSOSOMAL ACID LIPASE NORMALIZES LIVER WEIGHT, TRANSAMINASES AND HISTOPATHOLOGICAL ABNORMALITIES IN AN MODEL OF CHOLESTERYL ESTER STORAGE DISEASE
Authors: M. Leavitt, A.D. Burt, W. Hu, D. Canty, M. Gray, A. Bray, A. Harvey, C.P. Day, A.G. Ouinn
Journal: Journal of Hepatology (2011)
More must be done for head and neck cancer patients, audit shows
Authors: J. Wise
Journal: BMJ (2014)

Only 1 in 15 head and neck cancer patients receives all six elements of care recommended in the “ideal patient pathway,” the latest audit of cancer care in England has found.1

The ninth national head and neck cancer audit, commissioned by the Healthcare Quality Improvement Partnership, examined how well England’s 28 regional cancer networks were providing the ideal patient pathway, which aims to ensure that patients with head and neck cancer receive holistic and integrated care.

The pathway, based on agreed national standards developed by the British Association of Head and Neck …
Obesity in the United States
Authors: JoAnn E. Manson, Shari S. Bassuk
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ionic mechanisms of electronic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes.
Authors: Y Liu, W Zeng, M Delmar, J Jalife
Journal: Circulation (1993)

BACKGROUND The term "concealed conduction" is used in electrocardiography when a proximal (atrial or ventricular) impulse penetrates the atrioventricular (AV) node but fails to traverse it completely. Its penetration into the node is inferred by its after effects on the propagation of succeeding impulses. Concealed AV nodal conduction is a well-established phenomenon, but its precise cellular and subcellular mechanisms are unknown. It has been suggested that concealed conduction results from a transient impairment of excitability caused by the subthreshold depolarization (ie, electrotonic inhibition) that is elicited downstream of the site of block. METHODS AND RESULTS We studied the ionic mechanism of electrotonic inhibition and concealed conduction in single myocytes isolated from the rabbit AV node. Cells were paced using just-threshold current pulses delivered at a constant (basic) cycle length of 1 second. Appropriately timed interpolation of a conditioning pulse of depolarizing but subthreshold current led to failure of the subsequent, previously successful activation. The ability of the subthreshold response to inhibit subsequent excitation was increased when the interval between the conditioning and succeeding pulses was shortened, when the amplitude of the conditioning pulse was increased, or when the inward sodium current was blocked by superfusion with tetrodotoxin (30 microM). Voltage clamp analysis demonstrated that electrotonic inhibition results from partial inactivation of the transient calcium current (ICa.T). Similar results were obtained using a mathematical model (Hodgkin-Huxley type) of the AV nodal myocyte. Additional simulations in a linear array of AV nodal cells showed that when a premature impulse fails to traverse the AV node, the subthreshold depolarization elicited downstream of the site of block may lead to a transient reduction of excitability with consequent delay or block of the succeeding impulse. CONCLUSIONS The overall data strongly suggest that some of the electrocardiographic manifestations of concealed AV conduction are the result of electrotonic inhibition of excitability secondary to a transient decrease in ICa.T.
Childhood Trauma–Specific Reductions in Limbic Gray Matter Volume—Reply
Authors: Nicholas T. Van Dam, Rajita Sinha
Journal: JAMA Psychiatry (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Getting What You Ask For: On the Selectivity of Depression Rating Scales
Authors: Koen Demyttenaere, Jürgen De Fruyt
Journal: Psychotherapy and Psychosomatics (2003)

A large number of rating scales has been developed to assess depression severity and change during antidepressant therapy. When reviewing the literature, the choice of the rating scales used in a particular study often seems arbitrary. The most frequently used observer rating scales, the Hamilton Depression Rating Scale (HDRS) and the Montgomery-Åsberg Depression Rating Scale (MADRS), and the most frequently used self-rating scale (the Beck Depression Inventory, or BDI) were developed more than 20 years ago. Their historical background is too often forgotten and they are reflections of their origin: the HDRS and the MADRS reflect antidepressant activity while the BDI reflects psychotherapy. Moreover, the HDRS is at risk of putting ‘all depressions in one basket’, while the MADRS is at risk of putting ‘all antidepressants in one basket’. Therefore, the question whether a particular antidepressant could be more effective in a particular subtype of depression cannot be answered. Observer rating scales are more frequently used than self-rating scales, and when scales are used that do exist in an observer rating and a self-rating version, interesting differences are found. The present paper does not suggest that one scale is better than another, but suggests that a better knowledge of their differential background can help the researcher choose the correct scale for his purposes.
Thiocyanate Metabolism in Human Vitamin B12 Deficiency
Authors: D. G. Wells, M. J. S. Langman, J. Wilson
Journal: BMJ (1972)

Patients with subacute combined degeneration who smoked had significantly lowered plasma thiocyanate levels than control smokers, but plasma thiocyanate levels in non-smoking patients with neurological disease due to vitamin B(12) deficiency were not significantly different from control values. The results provide no support for the hypothesis that chronic cyanide intoxication is responsible for the occurrence of neurological disease in a minority of patients with vitamin B(12) deficiency, although they do not conclusively exclude this possibility. The association between smoking and subacute combined degeneration of the cord has been confirmed in this study but it remains unexplained.
Long-term Results of Iodine 125 Irradiation of Uveal Melanoma
Authors: Samuel Packer, Scott Stoller, Martin L. Lesser, Francine S. Mandel, Paul T. Finger
Journal: Ophthalmology (1992)

The authors report on 64 of the first 65 patients treated with iodine 125. The mean follow-up was 64.9 months. After treatment, 29 patients (45.3%) retained visual acuity of 20/100 or better, and 18 patients (28.1%) retained visual acuity within two lines of visual acuity before irradiation. Eleven patients (17.2%) died of metastasis, and 5 patients (7.8%) had local recurrence. Cataract developed in 29 (45.3%) patients; keratitis developed in only 2 (3.1%) patients, and dry eye developed in none. Neovascular glaucoma developed in 7 (10.9%) patients, and 15 (23.4%) patients had radiation retinopathy. Eleven patients (17.2%) required enucleation for either tumor growth or neovascular glaucoma. These results show the increasing number of radiation complications seen with long-term observation and the frequently seen adverse visual outcome.
Clinical Policies: Making Conflicts of Interest Explicit
Authors: William R. Phillips
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The development of clinical policies is important to patient care, health policy, legal standards, clinical research, and professional education. Many professional organizations are now involved in the development of such policies, calling them by a wide variety of names and using a broad range of methods. The American Medical Association recently compiled a list of more than 1500 policies, parameters, and guidelines. President Clinton has made the development and implementation of clinical policies central elements of his administration's program for health system reform. If a policy is to change clinical behavior, it must be credible to the practicing physician. The method pioneered by Eddy<sup>1</sup>makes major advances by basing clinical policies on the explicit examination of benefits, risks, costs, outcomes, and patient preferences. Credibility, however, will require that one additional element of the policy process be made explicit: the sources of support. Clinical policies will have
Medical management of the patient with cardiovascular disease
Authors: ALLEN G. MASK
Journal: Periodontology 2000 (2000)

Cigarette smoking, hypertension, hypercholesterolemia, and periodontal disease have been established as major risk factors for cardiovascular disease. Dentists and physicians should work aggressively to educate periodontitis patients about this relationship in an effort to improve the quality of health and contribute to their long-term survival. Blood pressure should be checked at the initial dental visit and at each subsequent visit in patients whose blood pressure is found to be high and/or has a history of hypertension. Dental and medical assistants should receive in-service training to assure competency in measuring blood pressures. All staff should be certified in basic cardiopulmonary resuscitation. Emergency protocol procedures should be in writing and rehearsed regularly. Patients should take their blood pressure medication as usual on the day of the dental procedure. It is helpful for the patients to bring all medications to the office for review at the time of the dental procedure. Good communication should be established between the dentist and physician to maximize good dental and physical health. Because the patient with periodontal disease is at an increased risk for cardiovascular disease, a standardized form should be developed for the convenient exchange of vital information, including but not limited to: blood pressure, medications, allergies, medical conditions and pertinent highlights of dental procedures. Minimize stress in patients with coronary artery disease. This includes providing solid local anesthesia, avoidance of intravascular medication injections, and encouraging relaxation techniques. Antibiotic prophylaxis is indicated in patients with valvular heart disease but does not guarantee the prevention of endocarditis. These patients should be alerted to monitor any symptoms such as fever, chills or shortness of breath. It has also been documented that toothbrushing, flossing and home plaque removers can cause transient bacteremia in periodontal patients. Epinephrine use should be avoided or utilized cautiously in patients with pacemakers or automatic defibrillator devices because of the possibility of refractory arrhythmia. Consultation with patient's cardiologist is advised. Anticoagulation with coumadin is not a contraindication to dental procedures. The prothrombin time or international normalized ratio laboratory values should be checked on the day of the procedure to assure that it is in an acceptable range. Aspirin therapy is not a problem unless the patient is on very high doses for severe arthritis. Continuing medical and dental education credits should emphasize cross-training in both areas to insure comprehensive treatment of the patient with periodontal disease. Smoking cessation, regular exercise, a low-fat diet and good dental hygiene contribute to a healthy cardiovascular system. Patients should understand as best we know the relationship between periodontal and cardiovascular disease to afford them an opportunity to improve their overall dental and physical health.
The Frequency of Aschoff Bodies in Atrial Appendages of Patients with Mitral Stenosis
Authors: B. H. RUEBNER, J. K. BOITNOTT
Journal: Circulation (1961)

Three hundred and sixteen biopsies of atrial appendages obtained at mitral valvotomy were studied histologically. They were divided into those with Aschoff bodies (41 per cent), those with nonspecific granulomas (23 per cent), and those without either lesion. These findings were compared with those of previous investigators. A study of 24 hearts with mitral stenosis and survey of the literature showed that Aschoff bodies in the left atrial appendage are usually accompanied by similar lesions in the rest of the heart. The average age of patients with Aschoff bodies in their atrial biopsy was 4 years less than that of those with "nonspecific granulomas" and more than 7 years less than that of patients without inflammatory foci in the endocardium. The etiology of "nonspecific granulomas" is discussed. Aschoff bodies were rare in patients with organized atrial thrombi, most of whom were fibrillating. Statistical analysis showed that thrombosis rather than fibrillation was the principal factor associated with a lowered incidence of Aschoff bodies. It was concluded that mechanical factors may determine the localization of rheumatic lesions in the heart. Elevated sedimentation rates were recorded as often in patients with negative biopsies as in those with Aschoff bodies. The percentage of positive biopsies fell from 66 per cent in patients aged 15 to 20 years to 14 per cent in patients aged over 55 years. The age incidence of Aschoff bodies has been compared with that of acute rheumatic fever, which is rare after the age of 15 years. It is concluded that in patients with mitral stenosis, histologic activity may continue for 20 years or more in the absence of clinical signs and symptoms. The proportion of positive biopsies was lowest in June and maximal in September. This seasonal change suggests that the histologic process is only intermittently active. The seasonal variation in the percentage of Aschoff bodies is discussed in relation to the seasonal incidence of acute rheumatic fever. Our results appear to establish the concept of a "subclinical" rheumatic process which has been postulated by many previous investigators.
Scotland to target NHS funding at poorer areas
Authors: B. Christie
Journal: BMJ (1999)

The most advanced formula yet developed in the United Kingdom for allocating NHS resources has been drawn up in Scotland and is aimed at targeting spending on areas of greatest need.

The new formula takes account for the first time of levels of deprivation and poverty and has been specifically designed to tackle health inequalities. Under the plans, which have been endorsed by the new Scottish parliament and are now open to consultation, some of the more prosperous areas of Scotland …
Family history of psoriasis and age at disease onset in Italian patients with psoriasis
Authors: E. Altobelli, R. Petrocelli, C. Marziliano, M.C. Fargnoli, M. Maccarone, S. Chimenti, K. Peris
Journal: British Journal of Dermatology (2007)

Journal Article Family history of psoriasis and age at disease onset in Italian patients with psoriasis Get access E. Altobelli, E. Altobelli Department of Internal Medicine and Public Health and Department of Dermatology, University of L'Aquila, Coppito‐Delta 6, 67100 L'Aquila, Italy Search for other works by this author on: Oxford Academic Google Scholar R. Petrocelli, R. Petrocelli Department of Internal Medicine and Public Health and Department of Dermatology, University of L'Aquila, Coppito‐Delta 6, 67100 L'Aquila, Italy Search for other works by this author on: Oxford Academic Google Scholar C. Marziliano, C. Marziliano Department of Internal Medicine and Public Health and Department of Dermatology, University of L'Aquila, Coppito‐Delta 6, 67100 L'Aquila, Italy Search for other works by this author on: Oxford Academic Google Scholar M.C. Fargnoli, M.C. Fargnoli Department of Internal Medicine and Public Health and Department of Dermatology, University of L'Aquila, Coppito‐Delta 6, 67100 L'Aquila, Italy Search for other works by this author on: Oxford Academic Google Scholar M. Maccarone, M. Maccarone Italian Association of Psoriatic Patients (ADIPSO), Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar S. Chimenti, S. Chimenti Department of Dermatology, University of Rome Tor Vergata, Rome, Italy E‐mail: emmaalto@tin.it; emma.altobelli@cc.univaq.it Search for other works by this author on: Oxford Academic Google Scholar K. Peris K. Peris Department of Internal Medicine and Public Health and Department of Dermatology, University of L'Aquila, Coppito‐Delta 6, 67100 L'Aquila, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 6, 1 June 2007, Pages 1400–1401, https://doi.org/10.1111/j.1365-2133.2007.07906.x Published: 01 June 2007
Clinical Remarks on the Treatment of Cancer of the Tongue
Authors: T. Annandale
Journal: BMJ (1875)

THE BRITISH MEDICAL 7OURNAL.localised points of contact.It was found easy to blow out of the tube a small quantity, say of powdered salt or sugar, on any spot previously fixed on.The following varieties of taste were examined: (I) sweet,(2) bitter, (3) saline, (4) alkaline, (5) acid, (6) astringent, and (7) fiery.This classification is that adopted by Bain and other psychologists, and appears to include all known tastes.Each substance was tested three times, and between each application the mouth was rinsed out with water.The patient did not see the substances employed.The following table shows at a glance the general result.Variety of taste.Substance.
Association between competing interests and authors' conclusions: epidemiological study of randomised clinical trials published in the BMJ
Authors: L. L Kjaergard
Journal: BMJ (2002)

To assess the association between competing interests and authors' conclusions in randomised clinical trials.Epidemiological study of randomised clinical trials published in the BMJ from January 1997 to June 2001. Financial competing interests were defined as funding by for profit organisations and other competing interests as personal, academic, or political.159 trials from 12 medical specialties.Authors' conclusions defined as interpretation of extent to which overall results favoured experimental intervention. Conclusions appraised on 6 point scale; higher scores favour experimental intervention.Authors' conclusions were significantly more positive towards the experimental intervention in trials funded by for profit organisations alone compared with trials without competing interests (mean difference 0.48 (SE 0.13), P=0.014), trials funded by both for profit and non-profit organisations (0.30 (SE 0.10), P=0.003), and trials with other competing interests (0.45 (SE 0.13), P=0.006). Other competing interests and funding from both for profit and non-profit organisations were not significantly associated with authors' conclusions. The association between financial competing interests and authors' conclusions was not explained by methodological quality, statistical power, type of experimental intervention (pharmacological or non-pharmacological), type of control intervention (for example, placebo or active drug), or medical specialty.Authors' conclusions in randomised clinical trials significantly favoured experimental interventions if financial competing interests were declared. Other competing interests were not significantly associated with authors' conclusions.
Overexpression of Melanoma-Associated Antigen D4 (Mage-D4) is an Independent Prognostic Factor in Squamous Cell Carcinoma of the Esophagus
Authors: Hisaharu Oya, Mitsuro Kanda, Hideki Takami, Yukiko Niwa, Masahiko Koike, Suguru Yamada, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Tsutomu Fujii, Hiroyuki Sugimoto, Shuji Nomoto, Michitaka Fujiwara, Yasuhiro Kodera
Journal: Annals of Oncology (2013)
Administration of potassium by subcutaneous infusion in elderly patients.
Authors: R J Schein, S Arieli
Journal: BMJ (1982)

1-31 x 109/1 after she was discharged.Results of liver function tests and lumbar puncture were normal.The titre of influenza A antibody was 256.During the first week she remained febrile and semi-conscious.She was treated with oxygen, parenteral nutrition, physiotherapy, and tracheal aspiration of tenacious green sputum.Erythromycin was stopped after 72 hours, when antibodies to Legionella were shown to be absent.Five days after