tbuckley/cabot-search huggingface dataset:
The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels
Authors: K.E. Harman, P.T. Seed, M.J. Gratian, B.S. Bhogal, S.J. Challacombe, M.M. Black
Journal: British Journal of Dermatology (2001)

Journal Article The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels Get access K.E. Harman, K.E. Harman St John's Institute of Dermatology, St Thomas' Hospital, London, U.K. *The Department of Public Health Sciences, Guy's Hospital, London, U.K. †The Department of Oral Medicine and Pathology, Guy's Hospital, Guy's, King's and St. Thomas' School of Medicine and Dentistry, King's College, London, U.K. Dr K.Harman, St. John's Institute of Dermatology, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K. E‐mail: karen.harman@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar P.T. Seed, P.T. Seed St John's Institute of Dermatology, St Thomas' Hospital, London, U.K. *The Department of Public Health Sciences, Guy's Hospital, London, U.K. †The Department of Oral Medicine and Pathology, Guy's Hospital, Guy's, King's and St. Thomas' School of Medicine and Dentistry, King's College, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.J. Gratian, M.J. Gratian St John's Institute of Dermatology, St Thomas' Hospital, London, U.K. *The Department of Public Health Sciences, Guy's Hospital, London, U.K. †The Department of Oral Medicine and Pathology, Guy's Hospital, Guy's, King's and St. Thomas' School of Medicine and Dentistry, King's College, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar B.S. Bhogal, B.S. Bhogal St John's Institute of Dermatology, St Thomas' Hospital, London, U.K. *The Department of Public Health Sciences, Guy's Hospital, London, U.K. †The Department of Oral Medicine and Pathology, Guy's Hospital, Guy's, King's and St. Thomas' School of Medicine and Dentistry, King's College, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar S.J. Challacombe, S.J. Challacombe St John's Institute of Dermatology, St Thomas' Hospital, London, U.K. *The Department of Public Health Sciences, Guy's Hospital, London, U.K. †The Department of Oral Medicine and Pathology, Guy's Hospital, Guy's, King's and St. Thomas' School of Medicine and Dentistry, King's College, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.M. Black M.M. Black St John's Institute of Dermatology, St Thomas' Hospital, London, U.K. *The Department of Public Health Sciences, Guy's Hospital, London, U.K. †The Department of Oral Medicine and Pathology, Guy's Hospital, Guy's, King's and St. Thomas' School of Medicine and Dentistry, King's College, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 4, 1 April 2001, Pages 775–780, https://doi.org/10.1046/j.1365-2133.2001.04132.x Published: 01 April 2001
Is the Global Rise of Asthma an Early Impact of Anthropogenic Climate Change?
Authors: Paul John Beggs, Hilary Jane Bambrick
Journal: Environmental Health Perspectives (2005)

The increase in asthma incidence, prevalence, and morbidity over recent decades presents a significant challenge to public health. Pollen is an important trigger of some types of asthma, and both pollen quantity and season depend on climatic and meteorologic variables. Over the same period as the global rise in asthma, there have been considerable increases in atmospheric carbon dioxide concentration and global average surface temperature. We hypothesize anthropogenic climate change as a plausible contributor to the rise in asthma. Greater concentrations of carbon dioxide and higher temperatures may increase pollen quantity and induce longer pollen seasons. Pollen allergenicity can also increase as a result of these changes in climate. Exposure in early life to a more allergenic environment may also provoke the development of other atopic conditions, such as eczema and allergic rhinitis. Although the etiology of asthma is complex, the recent global rise in asthma could be an early health effect of anthropogenic climate change.
Daily Diaries of Respiratory Symptoms and Air Pollution: Methodological Issues and Results
Authors: Joel Schwartz, David Wypij, Douglas Dockery, James Ware, Scott Zeger, John Spengler, Benjamin Ferris
Journal: Environmental Health Perspectives (1991)

Daily diaries of respirator symptoms are a poIfu technique for detecting acute effects ofair pollution exposure.While conceptually simple, these diary studies can be difficult to analyze.The daily symptom rates are highly correlated, even after adjustment for covariates, and this lack of independence must be considered in the analysis.Possible approaches include the use of incidence instead of prevalence rates and autoregressive models.Heterogeneity among subjects also in- duces dependencies in the data.These can be addressed by stratification and by two-stage models such as those developed by Korn and Whittemore.These approaches have been applied to two data sets: a cohort ofschool children participating in the Harvard Six Cities Study and a cohort ofstudent nurses in Los Angeles.Both data sets provide evidence ofautocor- relation and heterogeneity.Controlling for autocorrelation corrects the precision estimates, and because diary data are usually positively autocorrelated, this leads to larger variance estimates.Controlling for heterogeneity among subjects appears to increase the effect sizes for air pollution exposure.Preliminary results indicate associations between sulfur dioxide and cough incidence in children and between nitrogen dioxide and phlegm incidence in student nurses.
Histological Reassessment of Three Kidneys Originally Described by Richard Bright in 1827-36
Authors: R. O. Weller, B. Nester
Journal: BMJ (1972)

Portions of kidney from three patients with renal disease that were originally described by Richard Bright between 1827 and 1836 have been preserved in the Gordon Museum at Guy9s Hospital. Histological study has shown that two cases fall into the current diagnostic category of mesangiocapillary (membranoproliferative) glomerulonephritis. One of these patients had a five-year clinical history and died with chronic renal failure and uraemia. The other patient died after three to four months with a severe nephrotic syndrome. The third patient was a young woman with chronic "phthisis pulmonalis" and renal amyloidosis.
Does the Insertion Depth in Push Enteroscopy Depend on the Working Length of the Enteroscope?
Authors: C. Benz, R. Jakobs, J. F. Riemann
Journal: Endoscopy (2002)

Background and Study Aims: Using push enteroscopy, the small bowel can only be investigated in part. This preliminary prospective randomized study examined whether increasing the length of the enteroscope can have a beneficial effect on the insertion depth. Patients and Methods: Between August 1999 and December 1999, 28 consecutive patients were investigated using push enteroscopy and were randomly assigned to two groups. One group was investigated using the Olympus push enteroscope SIF-100 (working length 2200 mm). In the other group, the Olympus push enteroscope SIF-Q140 (working length 2500 mm) was used. All investigations were carried out using an overtube. The insertion depth was estimated by counting the folds in the small bowel. In addition, the insertion length was estimated in centimeters by withdrawing the instrument to the pylorus after straightening. Results: The two groups were comparable in terms of age, sex distribution, indication for enteroscopy, investigation time, and pathological findings. There were no significant differences in the insertion length between the two types of instrument. With the SIF-100, the median number of folds was 95 (range 30 - 213) and the insertion length was 72.5 cm (range 40 - 110 cm); and with the SIF-Q140, the median number of folds was 79 (range 18 - 203) and the insertion length was 70.0 cm (range 20 - 140 cm). Conclusions: As there was no significant difference in the insertion depth between the shorter instrument (Olympus SIF-100) and the longer one (Olympus SIF-Q140), it can be concluded from this preliminary study that there is no advantage in using a longer enteroscope. To document a significant difference, further studies with a larger numbers of patients would be necessary.
OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTIONS [PCI] BASED ON SEVERITY OF CORONARY ARTERY CALCIFICATION [CAC]
Authors: Anitha Rajamanickam, Christopher Varughese, Antony Innasimuthu, Mayur Lakhani, Rahul Sawant, Ravinder Rao, Jimmy Yee, Choudhury Hasan, Joseph Sweeny, Usman Baber, Robert Pyo, Pedro Moreno, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2014)
Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH".
Authors: M C Gershengorn, B D Weintraub
Journal: Journal of Clinical Investigation (1975)

An 18-yr-old woman with clinical and laboratory features of hyperthyroidism had persistently elevated serum levels of immunoreative thyrotropin (TSH). During 11 yr of follow-up there had been no evidence of a pituitary tumor. After thyrotropin-releasing hormone (TRH), there was a marked increase in TSH and secondarily in triiodothyronine (T3), the latter observation confirming the biologic activity of the TSH. Exogenous T3 raised serum T3 and several measurements of peripheral thyroid hormone effect, while decreasing serum TSH, thyroxine (T4), and thyroidal radioiodine uptake. After T3, the TRH-stimulated TSH response was decreased but was still inappropriate for the elevated serum T3 levels. Dexamethasone reduced serum TSH but did not inhibit TRH stimulation of TSH. Propylthiouracil reduced serum T4 and T3 and raised TSH. This patient represents a new syndrome of TSH-induced hyperthyroidism, differing from previous reports in the absence of an obvious pituitary tumor and in the responsiveness of the TSH to TRH stimulation and thyroid hormone suppression. This syndrome appears to be caused by a selective, partial resistance of the pituitary to the action of thyroid hormone. This case is also compared with previous reports in the literature of patients with elevated serum levels of immunoreactive TSH in the presence of elevated total and free thyroid hormones. A classification of these cases, termed "inappropriate secretion of TSH," is proposed.
Richter syndrome with two B cell clones possessing different surface immunoglobulins and immunoglobulin gene rearrangements
Authors: Shuji Tohda, Toshiya Suzuki, Kaoru Nagata, Takashi Kamiyama, Yasufumi Imai, Nobuo Nara, Nobuo Aoki, Tomohiro Morio
Journal: American Journal of Hematology (1990)

Abstract A patient with two populations of B cell malignancy in the bone marrow is reported. One population consisted of mature small lymphocytes, expressing surface IgM + D, λ and proliferating very slowly. The other population consisted of abnormal large lymphoid cells, expressing surface IgM, K and proliferating actively. We considered the former as chronic lymphocytic leukemia cells and the latter as malignant lymphoma cells. Therefore, this case was considered as Richter syndrome. The analysis of immunoglobulin heavy chain gene rearrangement showed the different patterns between the two populations. It suggested that the two populations arose from the different origins. We discussed the genetic relationship between the two clones of Richter syndrome referring to other reported cases.
HIV Infection and Residents
Authors: Bruce Doblin
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obstetrician's perspective—therapeutic trial and error?
Authors: Ian A Greer
Journal: BMJ (2004)

About 70% of pregnant women experience nausea and vomiting. This troublesome condition has been recognised in medical literature since the days of Hippocrates, who noted that it began soon after conception and continued until the end of the fourth month. Despite the longevity of our knowledge of this association, our understanding of the mechanism of this condition and its possible physiological protective role has advanced little. Indeed, sickness in pregnancy, like pre-eclampsia, remains a “disease of theories.” Many hypotheses have been advanced, ranging from psychological disturbance to nutritional deficiencies, disturbed thyroid function, and excessively high concentrations of chorionic gonadotropin.

Our ability to treat nausea and vomiting in pregnancy is hampered by our lack of knowledge, and treatment has been empirical, focusing …
Abstract 5200: Nestin regulates stem cell functions of pancreatic cancer cells
Authors: Yoko Matsuda, Masahito Hagio, Yuji Yanagisawa, Taeko Suzuki, Yoko Kawamoto, Kiyoko Kawahara, Zenya Naito, Toshiyuki Ishiwata
Journal: Cancer Research (2012)

Abstract Introduction: Nestin, a class VI intermediate filament, is expressed in pancreatic exocrine progenitor cells. Previously, we reported that 30% of PDAC cases expressed nestin in cancer cells, and its expression was correlated with invasion (Kawamoto, et al. Hum Pathol 2009). Knockdown of nestin using shRNA in human PDAC cell lines inhibited cell migration and invasion in vitro and liver metastasis in vivo. Restoring the expression level of nestin returned the inhibition of cell migration and invasion to the previous level (Matsuda, et al. Cancer Biol Ther 2011). In this study we analyzed the expression and roles of nestin in pancreatic cancer stem cells. Methods: Expressions of stem cell markers and nestin were analyzed using immunocytochemistry and real-time PCR. To assess cancer stem cells, a sphere formation assay was performed as follows: cells were grown in an ultra-low attachment surface plate supplemented with epithelial growth factor and fibroblast growth factor 2. Nestin-regulating molecules were clarified by DNA microarray analysis. Results: The expression level of nestin was high in sphere-forming PDAC cells, and its expression levels correlated with sphere-forming ability. In DNA microarray analysis using nestin shRNA-transfected clones and nestin-expression vector transfected-clones, at a 2-fold cut-off, only transcriptional factor 4 (TCF4) showed a compatible change coincident with nestin expression. It has been reported that TCF4 is involved in the Wnt pathway, and negatively regulates the transcription of NANOG. In real-time PCR, expression levels of TCF4 and NANOG correlated with nestin expression level. Conclusion: Nestin expression levels correlated with sphere-forming ability and expression levels of TCF4 and NANOG. These results indicate that nestin regulate stemness via TCF4 and NANOG.The expression of nestin is associated with highly metastatic cancer stem-like cells, and nestin regulates migration, invasion, and metastasis by altering the pancreatic cancer stem cell function. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5200. doi:1538-7445.AM2012-5200
Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?
Authors: Martin J. S. Dyer, Takashi Akasaka, Melania Capasso, Palminder Dusanjh, Yin Fai Lee, E. Loraine Karran, Inga Nagel, Inga Vater, Gunnar Cario, Reiner Siebert
Journal: Blood (2009)
Gutkha wars: India toughens up on oral tobacco use
Authors: Meera Kay
Journal: BMJ (2012)

Most style factor exchange-traded funds (ETFs) use some simple heuristic method of portfolio construction, such as equal weighting or capitalization weighting. This inevitably results in inefficient portfolios that are likely to have significant unintended factor bets, and the returns to these can easily dominate the returns to the chosen style factor. The author uses a simple stock selection rule to create different style factor ETFs using a number of heuristic portfolio construction methods, including equal weighting, capitalization weighting, attribute weighting, inverse volatility, risk parity, and Markowitz optimization. The author also introduces a modified version of Markowitz optimization that identifies the most inefficient holdings in an existing portfolio and only allows limited trading in those stocks; the purpose is to gain a significant improvement in overall efficiency without too much turnover. Each of the strategies is rebalanced quarterly from the beginning of 2006 to 2019. Because the stock selection is always the same, the resulting differences in performance and turnover are due entirely to the different methods of portfolio construction. <b>TOPICS:</b>Portfolio construction, exchange-traded funds and applications <b>Key Findings</b> • Style factor ETFs purport to offer investors the opportunity to capture the factor risk premium of the target style. • However, if these portfolios are not constructed efficiently, the contribution of the target style factor premium to the overall return on the portfolio is very likely to be dominated by other, unintended factor bets. • Smart portfolio optimization can maximize the effect of the target style factor premium on the return to the ETF portfolio and minimize all other effects.
Evaluation of Operability in Patients with Pulmonary Hypertension by Catheterization and Occlusion of Patent Ductus Arteriosus
Authors: A. ACTIS-DATO, A. TARQUINI
Journal: Circulation (1959)

The authors describe a technic of temporary occlusion of the patent ductus arteriosus during right heart catheterization by a balloon filled with contrast medium connected to the tip of the catheter. This procedure is a valuable aid in the selection of patients with patent ductus arteriosus and severe pulmonary hypertension for operation.
A Case of Sciatic Nerve-Stretching in Locomotor Ataxy: With remarks on the Operation
Authors: J. Cavafy
Journal: BMJ (1881)

the greatest boons to surgery that this century has produced, if not the greatest.I have spoken of the daily dressings of these cases that were formerly necessary.What is now the case ?I-find that three or four dressings are, in the great majority of cases, sufficient during the healing of the wound.In one of my last cases, two dressings would have been suffi- cient; for, on dressing it the third time, I found, not only everything perfectly aseptic, but the wound healed, and I regretted much that I subjected the patient to an unnecessary disturbance.In truth, there is no such test-case for illustrating the value of antiseptic surgery as exci- sion of the knee-joint.It is much more so than ovaxiotomy, or any of the other operations connected with abdominal surgery.There are many circumstances which militate against --immediate union being obtained after a resection of the knee.In the first place, the cases requiring so formidable an operation are, as a rule, in a condition of great physical exhaustion consequent on long con- finement, and probably protracted suffering, of both mind and body.The wound that is made is of necessity large; the operation, when done with the necessary care, occupies a considerable time.Two large freshly cut bone-surfaces are made, between which union is to take place; and, lastly, there is the great difficulty of keeping, no matter what appliance be adopted, the limb absolutely at rest during the process of union.As a proof of the great difficulty of getting ready union that used to be experienced, I may mention that formerly six, eight, ten months, or even longer, elapsed before union used to
Rapid Death in Bile Peritonitis
Authors: D. M. Douglas, G. G. Turner
Journal: BMJ (1940)

to the fact that the animals were not permitted to live to the age for produLction of lung tuLmours or the animals emnployed were not sensitive to the development of lung t umours.Animal experiment has not yet established the cause of lung cancer in the Schneeberg and Joachimsthal miners.1 am indebted to the Joachimsthal auLthorities, to Professor J. Lowy, and to the Mond Nickel Company for supplying samples of dust;
Hypertension, Bilateral Renal Artery Stenosis, Adrenocortical Adenomas, and Normal Serum Electrolyte Levels
Authors: Henry S. Bloch
Journal: JAMA (1966)

Aortography revealed bilateral renal artery stenosis in a patient with hypertension, diabetes mellitus, normal serum electrolyte levels, normal excretion of hydroxycorticosteroids, and increased excretion of aldosterone. Following an attempt at surgical correction of the stenosis, the patient died of a myocardial infarction. The autopsy revealed two adrenal adenomas which were morphologically indistinguishable from aldosterone-producing tumors. Therefore, the patient's hypertension would most likely not have been cured by correction of the renovascular lesions alone. Because concurrence of primary aldosteronism and renal artery stenosis is probably not rare, it is suggested that patients with renal artery stenosis be explored for adrenal adenomas prior to correction of the stenosis.