tbuckley/cabot-search huggingface dataset:
Lymphocytes bearing Fc gamma receptors in rheumatoid arthritis. I. An increased subpopulation of cells in rheumatoid arthritis detected with Facb rosettes.
Authors: N.D Hall, V.R Winrow, P.A Bacon
Journal: Annals of the Rheumatic Diseases (1980)

The chronic production of IgM and IgG antiglobulins is a major feature of rheumatoid arthritis. This implies an abnormal interaction between rheumatoid leucocytes and IgG. A novel rosette assay employing rabbit Facb-coated calf red blood cells has been developed to study receptors for IgG on peripheral blood lymphocytes. Cells were obtained from groups of patients with rheumatoid arthritis (RA), osteoarthritis (OA), ankylosing spondylitis (AS), and healthy control subjects. Receptors for Facb were found on an increased proportion of lymphocytes from RA patients compared with the other groups tested. It has been shown that the Facb rosette assay detects a subpopulation of lymphocytes bearing receptors for the Fc region of IgG. This receptor is clearly capable of recognising and binding only the C gamma 2 domain within the Fc region. As such it shows different specificity from some other Fc receptors detected on mononuclear cells. The number of Facb rosette-forming lymphocytes in an individual sample correlated well with the number of cells bearing 'high avidity' Fc receptors. However, the incidence of these cells in RA patients could not be correlated with disease activity, disease duration, or levels of IgM and IgG rheumatoid factor. Thus increased Facb rosette cells may represent a fundamental imbalance of the immune response in patients with rheumatoid arthritis.
Pulmonary Blood Flow: Erratum
Authors: HOMAYOUN KAZEMI
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 December 1970Pulmonary Blood Flow: ErratumHOMAYOUN KAZEMI, M.D.HOMAYOUN KAZEMI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-6-1042_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am writing to you about our article entitled "Alteration in Distribution of Pulmonary Blood Flow: An early Manifestation of Alpha1-Antitrypsin Deficiency," which appeared in the September 1970 issue of the ANNALS. There is an error in the paper; on page 400 Figures 2 and 3 have been switched. Figure 3 should appear with the legend that is given for Figure 2 and Figure 2 with the legend that is given for Figure 3. This error makes understanding the discussion a little difficult. Close attention to the legends, however, would make it obvious that the figures have... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pulmonary Unit Massachusetts General Hospital Boston, Mass. 02114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1970Volume 73, Issue 6Page: 1042-1042KeywordsBlood flow Issue Published: 1 December 1970 PDF DownloadLoading ...
Patients win right to have their advance decisions honoured
Authors: Clare Dyer
Journal: BMJ (2007)

A new statutory right for patients to say in advance what treatments they would want to refuse if they later lose the capacity to take decisions came into force this week.

Doctors will have to abide by the new advance decisions to refuse treatment (ADRTs) or risk criminal or civil proceedings in the courts.

The measure forms part of the Mental Capacity Act 2005, which from October 1 also gives individuals the right to create a lasting power …
CLASSIFICATION AND MEDICAL RELATIONSHIPS OF HYPERTENSIVEALBUMINURIC PREGNANCY
Authors: A. J. B. TILLMAN
Journal: JAMA (1942)

There are three concepts of the etiology of hypertensive-albuminuric pregnancy: (1) that it is the same disease and has the same etiology as in the nonpregnant state, (2) that it is the same disease as in the nonpregnant state plus additional disease directly due to the pregnancy, and (3) that it is a disease primarily due to the pregnancy.   If the first is true, then any classification of hypertensive-albuminuric pregnancy should be identical with the classification of such disease in the nonpregnant state. There are certain adherents to this belief and at times I have been one. The difficulty in accepting this view is the occurrence in pregnancy of the typical convulsive state called eclampsia, the clinical picture of which is not reproduced under any circumstances in the nonpregnant state.  Herrick has suggested that this syndrome may be regarded as acute hypertension, but proof of this is lacking, and
The cognitive science of souls: Clarifications and extensions of the evolutionary model
Authors: Jesse M. Bering
Journal: Behavioral and Brain Sciences (2006)

The commentaries are a promising sign that a research programme on the cognitive science of souls will continue to move toward empirical and theoretical rigor. Most of the commentators agree that beliefs in personal immortality, in the intelligent design of souls, and in the symbolic meaning of natural events can provide new insight into human social evolution. In this response I clarify and extend the evolutionary model, further emphasizing the adaptiveness of the cognitive system that underlies these beliefs.
Biopsy of potentially operable hepatic colorectal metastases is not useless but dangerous
Authors: Oliver M Jones, Myrddin Rees, Tim G John, Sean Bygrave, Graham Plant
Journal: BMJ (2004)

EDITOR—We have followed with interest the debate about tumour seeding in the aftermath of fine needle aspiration cytology (FNAC) in patients with potentially resectable hepatic colorectal liver metastases.1 The verdict of Metcalfe et al of “useless and dangerous” seems to have provoked strong emotions among some of your readers, and we should like to contribute two observations.

Our staging protocol comprises …
Stable Expression and Coupling of Cardiac L-Type Ca <sup>2+</sup> Channels With β <sub>1</sub> -Adrenoceptors
Authors: Atsuko Yatani, Minoru Wakamori, Tetsuhiro Niidome, Satoshi Yamamoto, Isao Tanaka, Yasuo Mori, Kouich Katayama, Stuart Green
Journal: Circulation Research (1995)

Abstract A number of neurotransmitters modulate cardiac dihydropyridine-sensitive L-type Ca 2+ channels through several homologous G protein–coupled receptors. Previous studies that have examined receptor–Ca 2+ channel interactions have suffered because of the coexpression of various receptor subtypes in native cells. To study the functional coupling of a particular receptor subtype to these channels, rabbit cardiac Ca 2+ channel α 1 and skeletal β and α 2 /δ subunits were stably expressed in baby hamster kidney cells. In this stable cell line, Ca 2+ channels remained at high levels (&gt;1000 fmol/mg protein, or 2700 channels per cell) over extended times. The expressed recombinant Ca 2+ channels displayed the voltage dependence of activation and inactivation, unitary conductance, and pharmacology characteristic of native cardiac L-type Ca 2+ channels. Subsequent coexpression of the β 1 -adrenoceptors (150 to 300 fmol/mg protein) with the Ca 2+ channels resulted in cell responsiveness to the extracellular application of isoproterenol. These results indicate that heterogeneous expression in mammalian cells provides a useful system for studying both biophysical analysis of Ca 2+ channel properties and receptor-coupled regulatory processes.
Clinical effects of spinal cord stimulation in patients with refractory angina pectoris: Results from a prospective italian registry
Authors: Gaetano A. Lanza, Francesco Di Pede, Guerrino Zuin, Massimo Romanò, Dino Rapati, Antonio Circo, Paola Cardano, Fulvio Bellocci, Ottavio Alfieri, Massimo Santini, Attilo Maseri
Journal: Journal of the American College of Cardiology (2003)
Rheumatoid arthritis and malabsorption.
Authors: B Lake
Journal: BMJ (1972)

operation and no unpleasant effects follow."This report thus appeared over a year be- fore Morton's demonstration on the use of ether, and I think it is only right to point out that nitrous oxide was in use during the period between Wells's unsuccessful demon- stration and Morton's successful one.-Iam, etc., VICTOR GOLDMAN London W.1Ketamine for Burns Surgery SIR,-The leading article "Analgesia for Burnt Patients: A Symposium" (20 May, p. 418), gives much needed publicity to a hitherto neglected facet of anaesthetic practice.The sentence on the paper and discussion on the use of ketamine as an anaesthetic agent for burns surgery is somewhat biased.It is strange to mention one of the less common and least dangerous side effects of ketamine, without making any reference to the drug's unique advantages, especially in the field of bums surgery.-Weare, etc.,
Nonvisualization of Kidney
Authors: Howard M. Pollack
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The answers given by each of 2 consultants to a question on nonvisualization of a kidney on excretory urography (<i>JAMA</i><b>175</b>:830 [March 4] 1961) contain statements which require clarification: 1. Both consultants state that the renal excretion of indigo carmine proceeds by means of glomerular filtration. The exact method of excretion of this dye in the human has not been worked out. However, judging from its pattern of excretion in other mammals, its secretion in aglomerular fish, and its tendency to be bound to serum protein, there is much more justification in assuming its tubular secretion than in assuming its glomerular filtration. Actually, since the questioner does not state which dye was used, the assumption that indigo carmine was the agent in question seems unwarranted. 2. The first consultant states that the organic iodide used in intravenous urography is secreted mainly by the renal tubules, and
In Vivo Gene Delivery to Synovium by Lentiviral Vectors
Authors: Elvire Gouze, Robert Pawliuk, Carmencita Pilapil, Jean-Noel Gouze, Christina Fleet, Glyn D. Palmer, Christopher H. Evans, Philippe Leboulch, Steven C. Ghivizzani
Journal: Molecular Therapy (2002)

The delivery of anti-arthritic genes to the synovial lining of joints is being explored as a strategy for the treatment of rheumatoid arthritis. In this study, we have investigated the use of VSV-G pseudotyped, HIV-1-based lentiviral vectors for gene delivery to articular tissues. Recombinant lentivirus containing a β-galactosidase/neomycin resistance fusion gene under control of the elongation factor (EF) 1α promoter efficiently transduced human and rat synoviocytes and chondrocytes in cell culture. When directly injected into the knees of rats, this vector transduced synovial lining cells, but not other articular tissues such as cartilage. We also constructed a lentiviral vector containing the human interleukin-1 receptor antagonist (IL1RA) cDNA and examined transgene expression <i>in vitro</i> and <i>in vivo</i> following injection into the knee joints of rats. In immunocompetent animals, intra-articular IL1RA expression was high and persisted, at a sharply declining rate, for approximately 20 days. In immunocompromised rats, however, lentivirus-mediated intra-articular expression of human IL1RA was found to persist for at least 6 weeks. Extra-articular expression of the transgene was minimal. These results indicate that lentiviral vectors are capable of efficient <i>in vivo</i> gene transfer to synovium and merit further investigation as a means of providing long-term expression for gene-based treatments of arthritis.
Canine Scabies in Man: A Report of Human Mange
Authors: Mark H. Tannenbaum
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The recognition of scabies may present a ticklish problem to one not familiar with its many innuendos. It is not generally appreciated that<i>Sarcoptes scabiei canis</i>may infest man for short but memorable periods; there have been only two reports of this occurrence in the United States, both in the dermatologic literature.<sup>1,2</sup>Probably attack on humans by the dog mite is not this rare.<i>S scabiei canis</i>does not multiply on the human host and thus causes a self-limiting dermatitis; most of the instances of this disease go undetected. The treatment of scabies is very satisfactory; one application of an appropriate scabicide often results in death of the organism and prompt cessation of pruritus. To one scratching at the mites in the epidermis, the correct diagnosis and prompt therapy is of intense interest. To this end we report the third epidemic of<i>S scabiei canis</i>in
Effects of Nitroglycerin on Left Ventricular Wall Motion in Coronary Artery Disease
Authors: JAMES T. DOVE, PRAVIN M. SHAH, BERNARD F. SCHREINER
Journal: Circulation (1974)

The effects of sublingual nitroglycerin (GTN) on left ventricular wall motion (LVWM) were examined by angiographic assessment in eight patients with anginal chest pain. Five of seven patients having occlusive coronary artery disease showed segmental abnormalities in LVWM characterized by regional hypokinesis or akinesis at rest. These abnormalities were accentuated by tachycardia induced by atrial pacing and were associated with the development of anginal chest pain. Two patients with one vessel coronary artery disease had normal LVWM at rest, but developed abnormalities during the stress of tachypacing. Administration of GTN reversed the LVWM abnormalities in all patients despite continued tachypacing. One patient with atypical chest pain but normal coronary arteries had normal LVWM at rest, following tachypacing, and after GTN. It is concluded that angiographic evaluation of LVWM provides a useful measure of segmental myocardial ischemia in patients with suspected coronary artery disease, and permits objective assessment of effects of antianginal drugs in reversing myocardial ischemia.
Usefulness of omalizumab in ten patients with severe occupational asthma
Authors: F. Lavaud, P. Bonniaud, J. C. Dalphin, C. Leroyer, D. Muller, R. Tannous, G. Mangiapan, F. De Blay
Journal: Allergy (2013)

Abstract Background The management of severe occupational asthma ( OA ) remains problematic and new alternative treatments providing better disease control are required, ideally enabling affected individuals to remain in their job. Methods Ten patients with severe uncontrolled OA were treated with the monoclonal anti‐IgE antibody omalizumab. In six cases the causative agent was a high molecular weight ( HMW ) compound and in four cases it was a low molecular weight ( LMW ) chemical. All of the patients had well documented OA despite workplace adjustments. Results During treatment, nine patients exhibited a lower rate of asthma exacerbations and used less oral or inhaled corticosteroids. Seven patients were able to continue working at the same workplace as before treatment. Conclusion We have demonstrated that omalizumab is a potential treatment for severe uncontrolled OA and enabled seven of the ten patients in the study to remain in their job.
Interest Of Mass Spectrometry-Based Quantification Of Relevant Allergens To Improve The Standardization Of Allergen Extracts
Authors: Thierry Batard, Emmanuel Nony, Christel Dayang, Julien Bouley, Maxime Le Mignon, Christelle Berrouet, Aurélie Lautrette, Marie Naveau, Henri Chabre, Philippe Moingeon
Journal: Journal of Allergy and Clinical Immunology (2014)
Influence of oral contraceptives on body temperature.
Authors: R H Meyboom
Journal: BMJ (1991)

longer deserves (although it certainly did from 1988 to 1990) for indiscriminately encouraging markets, and also opprobrium it certainly does deserve (currently) for interfering obsessively in increasing central control of a supposedly newly devolved NHS.In the end we are left with the contracting process and the purchaser's ability to identifyneed-yet the rhetoric of consumerism.This may produce two forces for higher spending.Firstly, rationing based on purchasers' priorities translated into contracts with providers may still be politically unacceptable (hence the recent problems over interleukin at the Christie Hospital, Manchester).Yet, secondly, consumers will demand "production line" medicine and "trendy" procedures, whether they meet need, defined by experts, or not.In aggregate these forces will push for higher NHS spending.This may be fine.After all, Britain is a very low spender on health.And public spending is the most effective and efficient way to increase expenditure on health.The problem hitherto has been the conventional wisdom, on the right and the left, that only moving to an insurance based or partly private financing system could boost aggregate spending.It would be an ironv to be savoured if the long term fallout of the review was higher public spending and little or no reliance on competitive markets.
Epidemic of fatal encephalopathy in preschool children in Burkina Faso and consumption of unripe ackee (Blighia sapida) fruit
Authors: Honoré A Meda, Boukary Diallo, Jean-Pierre Buchet, Dominique Lison, Hubert Barennes, Amadou Ouangré, Moussa Sanou, Simon Cousens, François Tall, Philippe Van de Perre
Journal: The Lancet (1999)
Rac-Dependent Monocyte Chemoattractant Protein-1 Production Is Induced by Nutrient Deprivation
Authors: Neuza H.M. Lopes, Sanjay S. Vasudevan, David Gregg, Balakrishnan Selvakumar, Patrick J. Pagano, Herve Kovacic, Pascal J. Goldschmidt-Clermont
Journal: Circulation Research (2002)

Under ischemic conditions, the vessel wall recruits inflammatory cells. Human aortic endothelial cells (HAECs) exposed to hypoxia followed by reoxygenation produce monocyte chemoattractant protein-1 (MCP-1); however, most experiments have been performed in the presence of nutrient deprivation (ND). We hypothesized that ND rather than hypoxia mediates endothelial MCP-1 production during ischemia, and that the small GTP-binding protein Rac1 and reactive oxygen species (ROS) are involved in this process. ND was generated by shifting HAECs from 10% to 1% FBS. Superoxide production by HAECs was increased 6 to 24 hours after ND, peaking at 18 hours. MCP-1 production was increased over a similar time frame, but peaked later at 24 hours. These effects were blocked by treatment with antioxidants such as superoxide dismutase mimetic and N -acetylcysteine (NAC), or NADPH oxidase inhibitors, DPI and gp91ds-tat. Superoxide and MCP-1 production were enhanced by RacV12 (constitutively active) in the absence of ND, and were inhibited by RacN17 (dominant-negative) adenoviral transduction under ND, suggesting that the small G-protein Rac1 is required. In conclusion, ND, an important component of ischemia, is sufficient to induce MCP-1 production by HAECs, and such production requires a functional Rac1, redox-dependent pathway.
Effect of capsaicin on electrical slow waves in the isolated cat colon.
Authors: S Anuras, J Christensen, D Templeman
Journal: Gut (1977)

Because of the laxative effect of capsaicin, we examined the effect of that agent on the electromyogram of the isolated cat colon. At a concentration of 10(-4)M, it caused a significant reduction in the frequency of the electrical slow waves in the proximal half of the colon. Frequency fell to its lowest value, 45% of control (P less than 0-001), in the most proximal 10% of the organ below the ileocecal junction, and the effect progressively diminished along the colon. In the distal half of the colon, the change in frequency was not significant. Sectioning of the colon into segments reduced the frequency of the slow waves in the proximal half of the colon, and capsaicin, in a concentration of 10(-4)M, further reduced the frequency in the segments representing the proximal 30% of the colon. This effect of capsaicin is like that reported previously with other laxative agents.
Some pharmacologic and toxicologic effects of di-2-ethylhexyl phthalate (DEHP) and other plasticizers.
Authors: R J Rubin, R J Jaeger
Journal: Environmental Health Perspectives (1973)

With the recent demonstration of the migration of phthalate ester plasticizers from vinyl plastic biomedical devices (1-4), its identification in human and animal tissues (5, 6), and evidence for its ubiquitous distribution in the environment (7, 8),tt it has become necessary to reevaluate the toxicologic potential of this class of chemi- cal compounds.Di-2-ethylhexyl phthalate (DEHP), as an example of the most widely used of the phthalate esters, deserves par- ticular emphasis.In general, the phthalate esters have been reported to have a low order of acute toxicity (9-11).For example, of eight different phthalate esters examined in one study, the intraperitoneal LD50 dose in mice ranged from 1.5 to 14.2 g/kg.In rats, the intraperitoneal LD50 of DEHP has been reported by several investigators to range from 2 to 31 g/kg.One report
Cosmas and Damian
Authors: Joseph E. Murray
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Regarding the issue with the picture of SS. Cosmas and Damian on the cover (Sept 25, 1967), the twin brothers have been the subject of many paintings throughout the centuries. Having been interested in human organ transplantation, I have observed with more than casual perusal the various portrayals of the two saints to determine whether or not they are pictured as monozygotic twins. It is prophetic that the patron saints of medicine and surgery whose chief medical feat was transplantation between humans should appear as monozygotic twins. As is well known, the first successful, permanent skin transplantation by Padgett and Brown was between identical twins, and the first successful kidney transplant was, likewise, between monozygotic twins.
Mild spherocytosis and altered red cell ion transport in protein 4.2–null mice
Authors: Luanne L. Peters, Hitesh K. Jindel, Babette Gwynn, Cathy Korsgren, Kathryn M. John, Samuel E. Lux, Narla Mohandas, Carl M. Cohen, Michael R. Cho, David E. Golan, Carlo Brugnara
Journal: Journal of Clinical Investigation (1999)

Protein 4.2 is a major component of the red blood cell (RBC) membrane skeleton. We used targeted mutagenesis in embryonic stem (ES) cells to elucidate protein 4.2 functions in vivo. Protein 4.2–null (4.2–/–) mice have mild hereditary spherocytosis (HS). Scanning electron microscopy and ektacytometry confirm loss of membrane surface in 4.2–/– RBCs. The membrane skeleton architecture is intact, and the spectrin and ankyrin content of 4.2–/– RBCs are normal. Band 3 and band 3–mediated anion transport are decreased. Protein 4.2–/– RBCs show altered cation content (increased K+/decreased Na+)resulting in dehydration. The passive Na+ permeability and the activities of the Na-K-2Cl and K-Cl cotransporters, the Na/H exchanger, and the Gardos channel in 4.2–/– RBCs are significantly increased. Protein 4.2–/– RBCs demonstrate an abnormal regulation of cation transport by cell volume. Cell shrinkage induces a greater activation of Na/H exchange and Na-K-2Cl cotransport in 4.2–/– RBCs compared with controls. The increased passive Na+ permeability of 4.2–/– RBCs is also dependent on cell shrinkage. We conclude that protein 4.2 is important in the maintenance of normal surface area in RBCs and for normal RBC cation transport.