tbuckley/cabot-search huggingface dataset:
Coadministration of Seasonal Influenza Vaccine and MVA-NP+M1 Simultaneously Achieves Potent Humoral and Cell-Mediated Responses
Authors: Richard D Antrobus, Tamara K Berthoud, Caitlin E Mullarkey, Katja Hoschler, Lynda Coughlan, Maria Zambon, Adrian VS Hill, Sarah C Gilbert
Journal: Molecular Therapy (2013)

Current seasonal influenza vaccines have reduced immunogenicity and are of suboptimal efficacy in older adults. We have previously shown that the novel candidate vaccine MVA-NP+M1 is able to boost memory T cell responses in adults aged 50-85 years. Preclinical studies have demonstrated that viral vectored vaccines can act as adjuvants when coadministered with protein-based vaccines. We have conducted a phase I clinical trial to compare the coadministration of seasonal influenza vaccine and MVA-NP+M1 with seasonal influenza vaccine alone in adults aged 50 years and above. This combination of vaccines was safe and well tolerated. T cell responses to internal influenza proteins were boosted to significantly higher levels in the group receiving MVA-NP+M1 compared with the group receiving seasonal influenza vaccine alone. Rates of seroprotection and seroconversion against the three vaccine strains were similar in both groups; however, there was a significant increase in the geometric mean titer ratio for the H3N2 component of seasonal influenza vaccine in the coadministration group. While some vaccine combinations result in immune interference, the coadministration of MVA-NP+M1 alongside seasonal influenza vaccine is shown here to increase some influenza strain-specific antibody responses and boost memory T cells capable of recognizing a range of influenza A subtypes.
Phenotypic identification of subclones in multiple myeloma with different chemoresistant, cytogenetic and clonogenic potential
Authors: T Paíno, B Paiva, J M Sayagués, I Mota, T Carvalheiro, L A Corchete, I Aires-Mejía, J J Pérez, M L Sanchez, P Barcena, E M Ocio, L San-Segundo, M E Sarasquete, R García-Sanz, M-B Vidriales, A Oriol, M-T Hernández, M-A Echeveste, A Paiva, J Blade, J-J Lahuerta, A Orfao, M-V Mateos, N C Gutiérrez, J F San-Miguel
Journal: Leukemia (2014)
Gene expression microarrays: glimpses of the immunological genome
Authors: Gordon Hyatt, Rachel Melamed, Richard Park, Reuben Seguritan, Catherine Laplace, Laurent Poirot, Silvia Zucchelli, Reinhard Obst, Michael Matos, Emily Venanzi, Ananda Goldrath, Linh Nguyen, John Luckey, Tetsuya Yamagata, Ann Herman, Jonathan Jacobs, Diane Mathis, Christophe Benoist
Journal: Nature Immunology (2006)
Most immature T-ALLs express Ra-IL3 (CD123): possible target for DT-IL3 therapy
Authors: L Lhermitte, A de Labarthe, C Dupret, H Lapillonne, C Millien, J Landman-Parker, O Hermine, A Baruchel, F Sigaux, E Macintyre, V Asnafi
Journal: Leukemia (2006)
Multiple Neuropathic Joints, Including the Wrist, in a Patient With Diabetes Mellitus
Authors: Marvin J. Feldman
Journal: JAMA (1969)

A patient with long-standing diabetes and associated peripheral neuropathy with autonomic dysfunction had neuropathic arthropathy (Charcot's joint) involving both feet, the left ankle, the right knee, and the left wrist. In spite of considerable deformity and extensive roentgenographic evidence of damage to these joints, there was only minimal pain. Roentgenograms of the left wrist revealed narrowing of the joint spaces between the carpal bones, with fragmentation and disorganization. An open biopsy demonstrated eroded articular cartilage, a normalappearing synovial membrane, and an absence of an inflammatory cellular infiltrate. This appears to be the first case, to our knowledge, of diabetic arthropathy in which the upper extremity was affected.
Abstract 3957: Cell death and growth arrest pathways mediating the actions of stilbene 5C in HCT-116 colon cancer cells
Authors: Moureq R. Alotaibi, Matthew J. Beckman, Xu Di, Ray Lee, David A. Gewirtz
Journal: Cancer Research (2012)

Abstract The stilbene derivative, cis-3, 4′, 5-trimethoxy-3′-aminostilbene (stilbene 5c), is a potentially potent antitumor agent that acts via binding to the colchicine-binding pocket in microtubules. Earlier studies have shown that stilbene 5c induces cell death in ovarian cancer cells and leukemic cells (Lee RM et al, 2008; Lee RM et al, 2008). The present study was designed to investigate the effectiveness of this microtubule poison against the HCT-116 human colon cancer cell line and its mechanisms of action. Time course studies demonstrated that stilbene 5c produces a biphasic decrease in cell viability. The capacity of the cells to proliferate was not restored upon removal of the drug after 6 days of exposure. Consistent with the results of the time course studies, β-galactosidase staining indicated that treatment with stilbene 5c also promotes senescence. In addition to senescence, stilbene 5c-treated HCT-116 cells displayed formation of autophagic vesicles by acridine orange staining, which was supported by fluorescence-activated cell sorting (FACS). Further evidence of autophagy was derived from treatment of HCT116 cells carrying an RFP-LC3 construct with stilbene 5c, in which LC3 puncta formation increased in a time-dependent manner. DAPI staining, TUNEL, and Annexin 5 staining indicated that apoptosis is also occurring in stilbene 5c-treated HCT-116 cells. Cell cycle analysis demonstrated growth arrest at both G1 and G2/M, and an increase in the subG1 population at days 3 and 5, which correspond to senescence and apoptosis respectively. Interestingly, DAPI and Hoechst staining revealed morphological changes in the cell nuclei (binucleated and micronucleated cells), which suggest that mitotic catastrophe may also serve as a mode of cell death after treatment with stilbene 5c. Consistent with previous studies in other experimental cancer models, this work indicates that stilbene 5c could potentially be effective against colon cancer through the promotion of multiple modes of cell death. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3957. doi:1538-7445.AM2012-3957
Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification
Authors: Tadahiro Nagaoka, Takayuki Fukuda, Shinnosuke Yoshida, Hirohito Nishimura, Dongwei Yu, Shun'ichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Hidenori Yamada, Hiroko Tada, Masaharu Seno
Journal: Journal of Controlled Release (2006)
Absence of Milk Antibodies in Milk Intolerance in Adults
Authors: T. M. Bayless, J. S. Partin, N. S. Rosensweig
Journal: JAMA (1967)

Milk intolerance, characterized by abdominal bloating, cramps, and diarrhea one to four hours after ingestion of one or two glasses of milk occurs in at least 5% of the adult white population and in over 75% of healthy Negroes.<sup>1</sup>In the majority of these persons, the enzyme which digests the milk sugar, lactose, is deficient, and their symptoms can be reproduced by lactose administration. So-called cow's milk allergy does not seem to play a role in this syndrome since the patients have no other allergic disorders and they are able to tolerate small quantities of milk without symptoms. In the past, serum antibodies to cow's milk or milk fractions in the serum of infants and children had been considered evidence of hypersensitivity to milk, but it is now believed that a true causal relationship between milk antibodies and clinical disease has not been proven.<sup>2</sup> To obtain further information
Baby P doctor is granted right to High Court hearing
Authors: C. Dyer
Journal: BMJ (2010)

Sabah Al-Zayyat, the paediatrician accused of failing to spot Baby P’s serious injuries two days before he died, has won the right to bring a High Court challenge to the General Medical Council’s refusal to let her avoid a public hearing by removing her name voluntarily from the medical register.

At the High Court in London Mr Justice Kenneth Parker ruled that her case should be heard the week beginning 22 November and that she be granted a stay of the GMC proceedings in the meantime.

On 25 October a GMC fitness to practise …
Adjuvant cyclophosphamide, methotrexate, and fluorouracil in patients with axillary node-positive breast cancer: an update of the Guy's/Manchester trial.
Authors: M A Richards, S M O'Reilly, A Howell, W D George, I S Fentiman, M A Chaudary, D Crowther, R D Rubens
Journal: Journal of Clinical Oncology (1990)

Between 1976 and 1985, 391 patients (202 premenopausal, 189 postmenopausal) with operable breast cancer and positive axillary lymph nodes were randomized after total mastectomy and axillary clearance to receive cyclophosphamide, methotrexate, and fluorouracil (CMF) (n = 193) or no adjuvant therapy (n = 198). After a median follow-up of 8 years, both relapse-free survival (RFS) and survival (S) were significantly prolonged in premenopausal patients receiving CMF (RFS, P less than .001; S, P = .003). Treatment with CMF resulted in a significant improvement in RFS in premenopausal patients both with steroid receptor-positive and steroid receptor-negative tumors and also in subgroups of premenopausal patients defined by the number of axillary nodes involved. Premenopausal patients who developed permanent amenorrhea following CMF had a significantly better RFS than those who continued to menstruate. Induction of amenorrhea following CMF was related to age, with almost all patients over 40 years becoming amenorrheic. For patients less than or equal to 40 years, development of amenorrhea following CMF did not influence outcome. No difference was detected between control and CMF groups (RFS, P = .9; S, P = .9) in postmenopausal patients nor in any subgroup of these patients. The results of this trial of the efficacy of CMF for improving RFS and S have strengthened with longer follow-up.
Use of Procalcitonin and C-Reactive Protein to Evaluate Vaccine Efficacy against Pneumonia
Authors: Shabir A Madhi, Jayvant R Heera, Locadiah Kuwanda, Keith P Klugman
Journal: PLoS Medicine (2005)

Pneumonia remains the leading cause of death in young children. The poor specificity of chest radiographs (CXRs) to diagnose pneumococcal pneumonia may underestimate the efficacy of pneumococcal conjugate vaccine in preventing pneumococcal pneumonia.The efficacy of nine-valent pneumococcal conjugate vaccine among children not infected with HIV (21%; 95% confidence interval, 1%-37%) increased when CXR-confirmed pneumonia was associated with serum C-reactive protein of 120 mg/l (12 mg/dl) or more and procalcitonin of 5.0 ng/ml or more (64%; 95% confidence interval, 23%-83%). Similar results were observed in children infected with HIV.C-reactive protein and procalcitonin improve the specificity of CXR to diagnose pneumococcal pneumonia and may be useful for the future evaluation of the effectiveness of pneumococcal conjugate vaccine in preventing pneumococcal pneumonia.
What does the future hold for Cardiovascular Research?
Authors: Karin R. Sipido
Journal: Cardiovascular Research (2012)

In the recent two decades, Cardiovascular Research has grown into a leading journal in the cardiovascular field. Strong leadership and regular renewal have boosted this growth. It is therefore with pride and not without some trepidation that we take over the editorial leadership. Michael Piper, David Garcia-Dorado and their team hand over a thriving journal. In their decade of leadership the journal has gone through significant transformation and has positioned itself as the basic science flagship of the European Society of Cardiology (ESC). The editors and their team have emphasized quality and impact of the published manuscripts and introduced active debate on ethics in science and publishing.1,2 They challenge the new editors to take it further forward in times that are likely to see major changes. What awaits us? To answer this we take a closer look at the nature of scientific publishing, the current (com)motions surrounding it, and the expectations of stakeholders.

‘Publish or perish’ has taken on a negative connotation by essentially referring to pressure on scientists to produce a tangible and measurable output from their work and the money invested in them. However, in its purest sense, it reflects the necessity to share results within the scientific community and open the data for scrutiny, to be built on, criticized or refuted. Putting novel data in the public domain is an essential step in research to advance the field, justify public spending, and recognize researchers and their work. Science and research ‘perish’ without a reliable and solid publication platform.

This puts demands on editors from different stakeholders. For authors the publication channel should ensure their work is read by their peers and used, as reflected in citations by colleagues, and, in the current climate, publications are a means to ‘gather points’ in the increasing quantification …
Role of endogenous oestrogen in aetiology of coronary heart disease: analysis of age related trends in coronary heart disease and breast cancer in England and Wales and Japan
Authors: D. A Lawlor
Journal: BMJ (2002)

approach. 12 Recent data also show that the use of broad spectrum intrapartum antibiotics might increase the incidence of necrotising enterocolitis. 13 Guidelines should therefore seek to minimise the overall number of women exposed.This study provides data that will aid the development of such guidelines in the United Kingdom.We thank everyone who contributed to this survey and in particular members of the Northern Neonatal Network, the medical records staff and Alice Downes, Jim Dodd, Roshan Adappa, Diane Snowden, and Dominic Sailor for retrieving the notes; and Edmund Hey, Louise Parker, and Unni Wariyar for support with the study design and the writing of this paper.
Efficacy of Intermittent Colchicine Therapy in Familial Mediterranean Fever
Authors: DANIEL G. WRIGHT
Journal: Annals of Internal Medicine (1977)

Nine patients with familial Mediterranean fever (FMF) were admitted to a controlled, double-blind trial to determine if there are patients with this disease who are able to abort their acute episodes of pain and fever with short courses of colchicine taken at the onset of attacks. Five patients completed their treatment assignments, and colchicine was significantly effective in aborting the attacks of three but was ineffective in two. The remaining four patients could not be assessed because of insufficient numbers of courses. During the 10 months of the trial, 28 courses of colchicine and 31 of placebo were taken during the early stages of FMF attacks. Twenty-one (75%) colchicine courses were followed by attacks considered to have been aborted, compared to only three (10%) placebo courses. This trial shows that patients can recognize the prodrome of their FMF attacks and that some patients can consistently abort their attacks with short courses of colchicine taken at the very onset of symptoms.
Imaging of Sinusitis in Wegener??s Granulomatosis
Authors: F DE GEETER, L VAN MAELE, P VAN DER VEKEN, A BOSSUYT
Journal: Clinical Nuclear Medicine (1989)

Involvement of the paranasal sinuses is nearly always present in patients with Wegener's granulomatosis. Sinusitis is a known cause of increased uptake in skeletal imaging agents in the skull. We report on a case of Wegener's granulomatosis in which the paranasal localization of the tracer was further documented by SPECT.
Attentional Correlates of Illness Anxiety in a Non-Clinical Sample
Authors: Geert A.C. Vervaeke, Theo K. Bouman, Lucia R. Valmaggia
Journal: Psychotherapy and Psychosomatics (1999)

&lt;i&gt;Background:&lt;/i&gt; Attentional processes are assumed to play an important role in the maintenance of illness anxiety, although empirical support is relatively scarce. &lt;i&gt;Methods:&lt;/i&gt; The present study explores the relationship between selective attention (i.e. private body consciousness and symptom reporting), intensive concentration (i.e. attentional control and sustained attention), and illness anxiety in 57 non-clinical subjects. &lt;i&gt;Results:&lt;/i&gt; Zero-order and multiple correlations suggest that illness anxiety is significantly related to cognitive failures in everyday life and private body consciousness and to a lesser extent to symptom reporting. &lt;i&gt;Conclusion:&lt;/i&gt; It is concluded that illness anxiety can be partly predicted from specific attentional variables. However, specific operationalizations of attentional parameters seems to determine the existence and magnitude of these relations.
Personal solar UV-A doses received by patients undergoing oral psoralen photochemotherapy for psoriasis
Authors: H. MOSELEY, B.L. DIFFEY, J.M. MARKS, R.M. MACKIE
Journal: British Journal of Dermatology (1981)

Patients undergoing oral psoralen photochemotherapy (PUVA) for psoriasis receive a known amount of UV-A in the treatment cubicle and an unknown amount of UV-A from sunlight. In order to measure the solar UV-A dose, fifty-six patients received a UV-sensitive film badge to be worn from the time they took their psoralen tablet throughout the course of the day, except during treatment. The UV-A doses measured in this way varied from less than 0.2 J cm-2 to 7 J cm-2, with a median of around 1 J cm-2. These results show that the solar UV-A received by patients who have been photosensitized by 8-MOP may not be insignificant in relation to the treatment dose.
Bystander activity of Ad-mda7: Human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism
Authors: Sunil Chada, Abner M. Mhashilkar, Rajagopal Ramesh, John B. Mumm, R. Bryan Sutton, Dora Bocangel, Mingzhong Zheng, Elizabeth A. Grimm, Suhendan Ekmekcioglu
Journal: Molecular Therapy (2004)

The melanoma differentiation-associated gene-7 (mda-7/IL24) is a unique member of the IL-10 family of cytokines, with ubiquitous tumor cell proapoptotic activity. Transduction of tumor or normal cells with the mda-7 gene results in secretion of glycosylated MDA-7 protein. Recent data indicate that secreted MDA-7 protein functions as a pro-Th1 cytokine and as a potent antiangiogenic molecule. MDA-7 protein binds two distinct type II cytokine heterodimeric receptor complexes, IL-20R1/IL-20R2 (type 1 IL-20R) and IL-22R1/IL-20R2 (type 2 IL-20R). In this study we analyzed the activity of glycosylated secreted MDA-7 against human melanoma cells. MDA-7 protein induces phosphorylation and nuclear translocation of STAT3 in melanoma cells via both type 1 and type 2 IL-20R. MDA-7 induces dose-dependent cell death in melanoma tumor cells. MDA-7 receptor engagement results in up-regulation of BAX and subsequent apoptosis induction; this effect is mediated by STAT3-independent signaling. Additional IL-10 family members (IL-10, -19, -20, and -22) also activate STAT3; however, these ligands do not activate death pathways in melanoma. In normal cells, MDA-7 can bind to its cognate receptors and induce phosphorylation of STAT3, without cytotoxic sequelae. This study defines a tumor-selective cytotoxic bystander role for secreted MDA-7 protein and identifies a novel receptor-mediated, STAT3-independent, and PKR-independent death pathway.
Peripheral Vascular Disease
Authors: Robert R. Linton
Journal: New England Journal of Medicine (1949)

THIS report considers peripheral vascular disease under the two main divisions of diseases of the arteries and diseases of the veins.Diseases of the ArteriesThe surgical treatment of peripheral vascular diseases has made tremendous strides in recent years. The role that the sympathetic nervous system plays in the control of the arterial circulation of the extremities and the benefits derived by sympathetic neurectomy in many conditions are certainly to be included in great advances made in the therapy of peripheral arterial disease. Improvements in surgical technic, especially of blood-vessel anastomoses, the availability of blood transfusions through the establishment of . . .
Cancer and the Smoke House
Authors: R. S. Srigley
Journal: JAMA (1963)

To the Editor:  —Insight into the mystery of the declining incidence of cancer of the stomach since the 1930's may be aided by an observation of my wife, who was reared in the corn belt of the midwest, where the smoke house was an essential part of the farm. Meats were smoked very heavily so that they would last through the summer months without refrigeration. Now that refrigeration is readily available, the smoke house has almost vanished from the farm.
Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy
Authors: Hiroshi Imamura, Yutaka Matsuyama, Eiji Tanaka, Takao Ohkubo, Kiyoshi Hasegawa, Shinichi Miyagawa, Yasuhiko Sugawara, Masami Minagawa, Tadatoshi Takayama, Seiji Kawasaki, Masatoshi Makuuchi
Journal: Journal of Hepatology (2003)

We conducted a retrospective cohort study to investigate factors to early and late phase recurrence of hepatocellular carcinoma (HCC).The study population consisted of 249 patients including 157 with cirrhosis who underwent hepatectomy for HCC. The endpoint was time-to-recurrence. Using a Cox regression model, factors to early and late phase recurrences were investigated censoring recurrence-free patients at the 2-year time point and in patients without recurrence at 2 years.Actuarial probability of overall recurrence at 1, 3, and 5 years were 0.301, 0.623, and 0.790, respectively, with a median follow-up of 624 days. Early recurrence was observed in 123 out of 249 patients; while late recurrence was found in 61 out of 113 patients. Factors to early recurrence were as follows: non-anatomical resection, presence of microscopic vascular invasion, and serum alpha-fetoprotein level >or=32 ng/ml. Those contributing to late phase recurrence were higher grade of hepatitis activity, multiple tumors, and gross tumor classification.Variables associated with metastatic recurrence were factors to early phase recurrence; whereas those related with elevated carcinogenesis contributed to late phase recurrence, thus providing an epidemiological evidence that different mechanisms, i.e. metastasis and de novo, are involved in intrahepatic recurrence after hepatectomy for HCC.
Diabetes Mellitus as a Risk Factor for Pancreatic Cancer
Authors: James Everhart
Journal: JAMA (1995)

<h3>Objective.</h3> —To evaluate diabetes mellitus as a risk factor for pancreatic cancer with the consideration that diabetes may also be a consequence of pancreatic cancer. <h3>Data Sources.</h3> —Pertinent studies of diabetes mellitus and pancreatic cancer published between 1975 and 1994 were identified from a MEDLINE search and from citations in articles and books. <h3>Study Selection.</h3> —Twenty of a total of 30 case-control and cohort studies met the two inclusion criteria: cases with a duration of diabetes of at least 1 year prior to either pancreatic cancer diagnosis or death and the ability to calculate an appropriate relative risk (RR) estimate and variance. <h3>Data Extraction and Synthesis.</h3> —The pooled RR and 95% confidence interval (CI) of pancreatic cancer for diabetics relative to nondiabetics was 2.1 (1.6 to 2.8). There was a tendency for a higher RR for the nine cohort studies (RR, 2.6; 95% CI, 1.6 to 4.1) than for the 11 case-control studies (RR, 1.8; 95% CI, 1.1 to 2.7). Requiring diabetes duration of at least 5 years resulted in an RR of 2.0 (95% CI, 1.2 to 3.2). <h3>Conclusion.</h3> —Pancreatic cancer occurs with increased frequency among persons with long-standing diabetes. (<i>JAMA</i>. 1995;273:1605-1609)