Lessons for Study of the Health Effects of Oil Spills
Authors: David A. Savitz, Lawrence S. Engel
Journal: Annals of Internal Medicine (2010)

Editorials19 October 2010Lessons for Study of the Health Effects of Oil SpillsFREEDavid A. Savitz, PhD and Lawrence S. Engel, PhDDavid A. Savitz, PhDFrom Brown University, Providence, RI 02912; and Memorial Sloan-Kettering Cancer Center, New York, NY 10065.Search for more papers by this author and Lawrence S. Engel, PhDFrom Brown University, Providence, RI 02912; and Memorial Sloan-Kettering Cancer Center, New York, NY 10065.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-8-201010190-00276 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Each environmental disaster is unique, with health consequences that depend on the intersection of the event, the geographic setting, and the characteristics of the local population. Yet, all environmental disasters require the identification of health consequences and strategies to mitigate them and provide lessons for how to do better in future disasters (1–6). The Prestige oil spill and the rigorous health effects research that has followed (7–9) have direct relevance for the affected population but are also part of the broader body of disaster epidemiology that includes study of chemical explosions in Bhopal, India, and Seveso, Italy; the Chernobyl nuclear disaster; and the World Trade Center attack. In this issue, the report by Rodríguez-Trigo and colleagues of health effects in fishermen who helped clean up the Prestige oil spill (7) provides an opportunity to consider practices that will facilitate study of health effects among the 50 000 workers and other persons exposed during the 2010 Deepwater Horizon spill and future incidents.Collect Exposure and Medical Histories From Workers as Early as PossibleIdeally, investigators studying health effects of environmental disasters would collect biological samples and histories from workers before the start of clean-up work, but such data are seldom available. Consequently, these data should be obtained as early as possible after the work begins and preferably before any work-related symptoms appear. Rapid data collection in the field requires partnerships among various stakeholders, including workers, industry, local universities, and government agencies.An essential first step in the collection of these data is to identify persons who may have been exposed. It can be particularly challenging to identify volunteer workers, who may have different safety training, access to protective equipment, and exposure opportunities than hired workers. Identifying and including workers no longer engaged in clean-up activities when a study commences is also important because such workers may have stopped because of exposure-related health effects. A study need not include all targeted workers; sampling may be more efficient, but it should be representative. To assess representativeness of the persons studied, it helps to collect as much information as possible from workers who do not enroll in studies.Conduct Detailed Exposure AssessmentThe urgency of immediate needs (such as saving lives and containing oil) can hamper efforts to methodically assess exposure, and opportunities for exposure assessment in the Deepwater Horizon spill are now largely retrospective. Developing job- or task-exposure matrices that encompass the broad spectrum of clean-up activities will help epidemiologists more accurately estimate exposure. Exposure assessment would benefit from collection of detailed spill-related work histories from the workers and their employers, information on use and effectiveness of protective equipment and worker safety training, and incorporation of area and personal exposure measurement data from government and private entities. Comparing health outcomes by exposure level among workers is likely to be the most informative, but it is also desirable to identify an appropriate unexposed comparison group.Consider a Broad Range of Health IssuesStudies should focus on health effects of the oil spill rather than solely on the health effects of the oil. Previous epidemiologic studies of oil spills have primarily focused on acute physical effects and psychological sequelae (10–14). Increasing evidence, largely from the Prestige oil spill, suggests that clean-up workers may also experience long-term respiratory effects and chromosomal damage (7–9). Studies in the Gulf of Mexico should investigate acute symptoms reported previously as well as delayed conditions, such as cancer. Leukemia, multiple myeloma, and melanoma are of particular interest on the basis of evidence from occupational studies of petrochemical workers (15, 16). Evidence of genotoxicity and chromosomal damage from the Prestige spill (7) demonstrates the importance of examining biomarkers, such as genetic, epigenetic, immune, and inflammatory alterations, because the latent period of some diseases, including cancer, is long. Mental health and domestic violence will also be important to investigate, given that the oil spill disrupted the region's economy.Plan Research to Guide Immediate Public Health Interventions and Advance ScienceResearchers should strive to generate information of immediate value to the affected community. Opportunities to identify health service needs, suggest interventions to ameliorate the ongoing effects of the disaster, and disseminate clear information need to be pursued. For example, data on the relationship between work practices and toxicant exposure can lead to modifications that can minimize exposure during remaining clean-up activities. Early data on the presence of elevated rates of acute psychiatric problems can be very valuable to health care service providers in the region. In the face of disaster, researchers must strive not only to advance science but also to provide information with potential immediate benefit.Recognize and Work Within the Political ContextControversy, litigation, and economic consequences follow most environmental disasters, and data from research on the health effects of the disaster will be used as ammunition in the battles that ensue. In the Deepwater Horizon spill, tension has already developed between the desire to fully investigate the health consequences of the spill and the desire to provide reassurance that will reinvigorate the region's tourism and seafood enterprises. In the face of such conflicts, results will inevitably be seen as supportive of one view and counter to another. Researchers need to be aware of this context and ensure that the scientific evidence is generated and disseminated in an objective, transparent manner. The funding and oversight of the research need to be carefully configured, with inclusion of external scientific, community, and worker advisory boards to ensure quality, credibility, and acceptability of the findings.Disaster epidemiology advances one disaster at a time, and the most recent report on the Prestige oil spill is a notable step forward. It reminds us of the importance of incorporating measurement of both biomarkers and clinical outcomes. As the research about the health effects of the Deepwater Horizon spill begins, we have seen improved efforts to provide safety training to clean-up workers and a deeper appreciation that the scope of such disasters includes psychological and economic effects on health (17). As researchers assume their rightful place among the responders to the Deepwater Horizon oil spill, they must be aware that their studies will provide much-needed information for the affected communities as well as for future communities who experience similar calamities.David A. Savitz, PhDBrown UniversityProvidence, RI 02912Lawrence S. Engel, PhDMemorial Sloan-Kettering Cancer CenterNew York, NY 10065References1. Pesatori AC, Consonni D, Bachetti S, Zocchetti C, Bonzini M, Baccarelli A, et al. Short- and long-term morbidity and mortality in the population exposed to dioxin after the “Seveso accident.”. Ind Health. 2003;41:127-38. [PMID: 12916742] CrossrefMedlineGoogle Scholar2. Savitz DA, Oxman RT, Metzger KB, Wallenstein S, Stein D, Moline JM, et al. Epidemiologic research on man-made disasters: strategies and implications of cohort definition for World Trade Center worker and volunteer surveillance program. Mt Sinai J Med. 2008;75:77-87. 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Health changes in fishermen 2 years after clean-up of the Prestige oil spill. Ann Intern Med. 2010;153:489-98. LinkGoogle Scholar8. Pérez-Cadahía B, Laffon B, Valdiglesias V, Pásaro E, Méndez J. Cytogenetic effects induced by Prestige oil on human populations: the role of polymorphisms in genes involved in metabolism and DNA repair. Mutat Res. 2008;653:117-23. [PMID: 18495522] CrossrefMedlineGoogle Scholar9. Zock JP, Rodriguez-Trigo G, Pozo-Rodriguez F, Barberà JA, Bouso L, Torralba Y, et al; SEPAR-Prestige Study Group. Prolonged respiratory symptoms in clean-up workers of the prestige oil spill. Am J Respir Crit Care Med. 2007;176:610-6. [PMID: 17556713] CrossrefMedlineGoogle Scholar10. Palinkas LA, Petterson JS, Russell J, Downs MA. Community patterns of psychiatric disorders after the Exxon Valdez oil spill. Am J Psychiatry. 1993;150:1517-23. [PMID: 8379557] CrossrefMedlineGoogle Scholar11. Campbell D, Cox D, Crum J, Foster K, Riley A. Later effects of grounding of tanker Braer on health in Shetland. BMJ. 1994;309:773-4. [PMID: 7950562] CrossrefMedlineGoogle Scholar12. Lyons RA, Temple JM, Evans D, Fone DL, Palmer SR. Acute health effects of the Sea Empress oil spill. J Epidemiol Community Health. 1999;53:306-10. [PMID: 10396538] CrossrefMedlineGoogle Scholar13. Morita A, Kusaka Y, Deguchi Y, Moriuchi A, Nakanaga Y, Iki M, et al. Acute health problems among the people engaged in the cleanup of the Nakhodka oil spill. Environ Res. 1999;81:185-94. [PMID: 10585014] CrossrefMedlineGoogle Scholar14. Janjua NZ, Kasi PM, Nawaz H, Farooqui SZ, Khuwaja UB, Najam-ul-Hassan , et al. Acute health effects of the Tasman Spirit oil spill on residents of Karachi, Pakistan. BMC Public Health. 2006;6:84. [PMID: 16584541] CrossrefMedlineGoogle Scholar15. Kirkeleit J, Riise T, Bratveit M, Moen BE. Increased risk of acute myelogenous leukemia and multiple myeloma in a historical cohort of upstream petroleum workers exposed to crude oil. Cancer Causes Control. 2008;19:13-23. [PMID: 17906934] CrossrefMedlineGoogle Scholar16. Schnatter AR, Theriault G, Katz AM, Thompson FS, Donaleski D, Murray N. A retrospective mortality study within operating segments of a petroleum company. Am J Ind Med. 1992;22:209-29. [PMID: 1415287] CrossrefMedlineGoogle Scholar17. Institute of Medicine. Assessing the Effects of the Gulf of Mexico Oil Spill on Human Health: A Summary of the June 2010 Workshop. Washington, DC: National Academies Pr; 2010. Google Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAuthors: David A. Savitz, PhD; Lawrence S. Engel, PhDAffiliations: From Brown University, Providence, RI 02912; and Memorial Sloan-Kettering Cancer Center, New York, NY 10065.Disclaimer: Dr. Engel is an investigator on the planned GuLF Study, a National Institutes of Health–administered health study for oil spill clean-up workers and volunteers.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-1904.Corresponding Author: David A. Savitz, PhD, Department of Community Health, Brown University, Box G-S-121-2, Providence, RI 02912; e-mail, [email protected]edu.Current Author Addresses: Dr. Savitz: Department of Community Health, Brown University, Box G-S-121-2, Providence, RI 02912.Dr. Engel: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 East 63rd Street, 3rd Floor, New York, NY 10065. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHealth Changes in Fishermen 2 Years After Clean-up of the Prestige Oil Spill Gema Rodríguez-Trigo , Jan-Paul Zock , Francisco Pozo-Rodríguez , Federico P. Gómez , Gemma Monyarch , Laura Bouso , M. Dolors Coll , Héctor Verea , Josep M. Antó , Carme Fuster , Joan Albert Barberà , and Metrics Cited byBroadening the Mandate of the Incident Command System to Address Community Mental and Behavioral Health Effects as Part of the Federal Response to DisastersSome clues for studying long-term health effects of oil spillsPotential Health and Safety Concerns for Oil spill Responders Working in Proximity to Spills of Unconventional Crude OilMutagenicity and oxidative damage induced by an organic extract of the particulate emissions from a simulation of the deepwater horizon surface oil burnsThe GuLF STUDY: A Prospective Study of Persons Involved in the Deepwater Horizon Oil Spill Response and Clean-UpEffects of exposure to oil spills on human health: Updated reviewTasman spirit oil spill in Pakistan: Research response and lessons learnedHealth Effects of Oil Spills: Lessons from the PrestigeThe Effect of Oil Spills on Workers Involved in Containment and AbatementThe Effect of Oil Spills on Workers Involved in Containment and Abatement: The Role of the Occupational Health Nurse 19 October 2010Volume 153, Issue 8Page: 540-541KeywordsEnvironmental healthEpidemiologyForecastingGenetic diseasesHealth economicsMedical servicesOil spillsOilsPrevention, policy, and public healthSafety equipment ePublished: 19 October 2010 Issue Published: 19 October 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. 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