The Relation of Capillary Angiopathy and Diabetes Mellitus to Idiopathic Edema
Authors: ETHAN A. H. SIMS
Journal: Annals of Internal Medicine (1965)

Article1 December 1965The Relation of Capillary Angiopathy and Diabetes Mellitus to Idiopathic EdemaETHAN A. H. SIMS, M.D., F.A.C.P., BRUCE R. MACKAY, M.D., TAKESHI SHIRAI, M.D.ETHAN A. H. SIMS, M.D., F.A.C.P., BRUCE R. MACKAY, M.D., TAKESHI SHIRAI, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-972 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere has long been recognized a group of patients who are prone to develop edema but in whom none of the obvious causes, such as cardiac failure, hypoproteinemia, renal disease, or allergic reactions, can be implicated (1-3). This syndrome has come to be known as idiopathic edema and is seen most often in premenopausal women who are somewhat overweight and who exhibit considerable tension and emotional lability. Some, however, including many of those in the present series, are neither obese nor emotionally labile. Retention of fluid occurs erratically and is at times marked, but it is not synchronized with the...References1. LUETSCHERLIEBERMAN JAAH: Idiopathic edema with increased aldosterone output. Trans. Amer. Ass. Physicians 70: 158, 1957. MedlineGoogle Scholar2. THORN GW: Editorial. Cyclical edema. Amer. J. Med. 23: 507, 1957. CrossrefMedlineGoogle Scholar3. MACHFABREMULLERNEHER RSJAFR: Oedèmes par retention de chlorure de sodium avec hyperaldostéronuria. Schweiz. Med. Wschr. 85: 1229, 1955. MedlineGoogle Scholar4. HILLHOODFARMERBURNUM SRWGTAJF: Idiopathic edema. Report of a case with orthostatic edema and hyperaldosteronism. New Eng. J. Med. 263: 1342, 1960. CrossrefMedlineGoogle Scholar5. EMERSONARMSTRONG KH: High protein edema due to diffuse abnormality of capillary permeability. Trans. Clin. Amer. Clim. Ass. 67: 59, 1955. MedlineGoogle Scholar6. ROSSCRABBÉRENOLDEMERSONTHORN EJJAEKGW: A case of massive edema in association with an aldosterone-secreting adrenocortical adenoma. Amer. J. Med. 25: 278, 1958. CrossrefMedlineGoogle Scholar7. CLARKSONTHOMPSONHORWITHLUCKEY BDMEH: Cyclical edema and shock due to increased capillary permeability. Amer. J. Med. 29: 193, 1960. CrossrefMedlineGoogle Scholar8. GOLDSMITHMERONEYBARTTER RSWHFC: Prominent peripheral edema associated with primary aldosteronism due to an adrenocortical adenoma. J. Clin. Endocr. 20: 1168, 1960. CrossrefGoogle Scholar9. STREETENLOUISCONN DHLHJW: Secondary aldosteronism in "idiopathic edema." Trans. Ass. Amer. Physicians 73: 227, 1960. Google Scholar10. MOSTOWHAMWISKILLMAN JHGJTG: Cyclical edema and reactive hypoglycemia. Psychosomatics 3: 17, 1962. CrossrefMedlineGoogle Scholar11. HOFFMAN WS: A rapid photoelectric method for the determination of glucose in blood and urine. J. Biol. Chem. 120: 51, 1937. CrossrefGoogle Scholar12. CONNFAJANS JWSS: The prediabetic state. A concept of dynamic resistance to a genetic diabetogenic influence. Amer. J. Med. 31: 839, 1961. CrossrefMedlineGoogle Scholar13. ULICKLARAGHLIEBERMAN SJHS: The isolation of a urinary metabolite of aldosterone and its use to measure the rate of secretion of aldosterone by the adrenal cortex of man. Trans. Ass. Amer. Physicians 71: 225, 1958. MedlineGoogle Scholar14. WATANABEMEEKERGRAYSIMSSOLOMON MCIMJEAS: Secretion rate of aldosterone in normal pregnancy. J. Clin. Invest. 42: 1619, 1963. CrossrefMedlineGoogle Scholar15. KLIMANBELLBARTTER BRNHFC: Albumin infusion: a new test for primary aldosteronism (abstract). Clin. Res. 9: 182, 1961. Google Scholar16. SIMSSTRAUSFELDGRAYSOLOMONO'CONNELL EAKMJMM: Aldosterone secretion, sodium space, and total body water during the normal menstrual cycle. In preparation. Google Scholar17. ZACKSPEGUESELLIOTT SIJJFA Interstitial muscle capillaries in patients with diabetes mellitus: a light and electron microscope study. Metabolism 11: 381, 1962. MedlineGoogle Scholar18. BLOODWORTH JM: Diabetic microangiopathy. Diabetes 12: 99, 1963. CrossrefMedlineGoogle Scholar19. BANSONLACY BBPE: Diabetic microangiopathy in human toes; with emphasis on the ultrastructural change in dermal capillaries. Amer. J. Path. 45: 41, 1964. MedlineGoogle Scholar20. LEELAULER JBDP: Continuous inulin and PAH clearance studies during prolonged administration of desoxycorticosterone (DOC) in normal man (abstract). J. Clin. Invest. 40: 1057, 1961. Google Scholar21. AUGUSTNELSONTHORN JTDHGW: Response of normal subjects to large amounts of aldosterone. J. Clin. Invest. 37: 1549, 1958. CrossrefMedlineGoogle Scholar22. NELSONAUGUST DHJT: Abnormal response of oedematous patients to aldosterone or desoxycortone. Lancet 2: 883, 1959. CrossrefMedlineGoogle Scholar23. LUETSCHERDOWDYARNSTEINLUCASMURRAY JAAJARCPCL: Ideopathic oedema and increased aldosterone excretion, in Aldosterone: a Symposium Organized by the C.I.O.M.S. Edited by BAULIEU, E. E., ROBEL, P. F. A. Davis Co., Philadelphia, 1964, p. 487. Google Scholar24. ROVNERCOHENCONNREYES-LEAL DRELJWB: Aldosterone, renin activity and sodium kinetics in idiopathic edema (abstract). Program of 47th meeting, Endocrine Society, New York, 1965. Google Scholar25. CLIFTSCHLETTERSPELLERTILLEYSTREETEN GWFEPJGPDH: Studies on the pathogenesis of idiopathic edema (abstract). Clin. Res. 13: 235, 1965. Google Scholar26. BIGLIERI EG: Hyperdesoxycorticosteronism with hypokalemic alkalosis and edema (abstract). J. Clin. Invest. 42: 917, 1963. Google Scholar27. MAHESHGREENBLATT VBRB: Ovarian production of desoxycorticosterone in a case of cyclic premenstrual edema (abstract). Program of the 47th meeting, Endocrine Society, New York, 1965. Google Scholar28. BENNETTLUFTHAMPTON HSJHJC: Morphological classification of vertebrate blood capillaries. Amer. J. Physiol. 196: 381, 1959. CrossrefMedlineGoogle Scholar29. SAMAANDOLLERYFRASER NCTR: Diabetogenic action of benzothiadiazines: serum-insulin-like activity in diabetes worsened or precipitated by thiazide diuretics. Lancet 2: 1244, 1963. CrossrefMedlineGoogle Scholar30. CAMERINI-DAVALOSCAULIFIELDREESLOZANO-CASTANEDANALDJIANMARBLE RAJBSBOSA: Preliminary observations on subjects with prediabetes. Diabetes 12: 508, 1963. CrossrefMedlineGoogle Scholar31. DAYSOGDOBSONBRENNAN AHLJC: Renal glomerular and vascular lesions in prediabetes and in diabetes mellitus: a study based on renal biopsies. Ann. Intern. Med. 54: 672, 1961. LinkGoogle Scholar32. LACY PE: The pancreatic beta cell, in The Aetiology of Diabetes Mellitus and its Complications. Vol. 15. Ciba Foundation Colloquia on Endocrinology. 1964, p. 79. CrossrefGoogle Scholar33. GILLCARRFLEISCHMANBARTTER JRAALEFC: Evidence for a role for the autonomic nervous system in experimentally-produced edema. Clin. Res. 13: 305, 1965. Google Scholar34. BARTTER FC Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Burlington, VermontFrom the Metabolic Unit, Department of Medicine, College of Medicine, University of Vermont, the Mary Fletcher and DeGoesbriand Memorial Hospitals, Burlington, Vt.This work was supported by U. S. Public Health Service grant 5-RO1-HD-00460, National Institutes of Health, Bethesda, Md.Dr. MacKay and Dr. Shirai are trainees under U. S. Public Health Service training grant T1-AM-5086, National Institutes of Health, Bethesda, Md.This paper was presented in part at the 5th Congress of the International Diabetes Association, Toronto, Can., July 24, 1964.Requests for reprints should be addressed to Ethan A. H. Sims, M.D., Metabolic Unit, Medical Alumni Building, University of Vermont, Burlington, Vt. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFluid Retention Syndrome in WomenIdiopathic edema: state of the artAn etiologic model proposing that non-insulin-dependent diabetes mellitus is chronic hypoxic stress hyperglycemiaIdiopathic edemaOpioid Peptides, Adrenocorticotropic Hormone, and Idiopathic (Orthostatic) EdemaIdiopathic Edema in a MaleIdiopathic oedema: case reports and reviewIdiopathic edema: Pathogenesis, clinical features, and treatmentIdiopathische �deme, Kapillaropathie und eiwei�reiche K�rperh�hlenerg�ssePapersKatamnesen und endokrinologische Befunde bei Frauen mit idiopathischem �demBig renin: Identification, chemical properties and clinical implicationsThe diagnosis and management of disorders of aldosterone productionMicrocirculation in diabetes mellitusIdiopathic ŒdemaIdiopathic edemaEdema and pulmonary edema: Pathologic physiology and differential diagnosisIdiopathic edemaSkeletal Muscle Capillaries in DiabeticsSkeletal Muscle Capillaries in NondiabeticsElektronenmikroskopische Untersuchungen an Skeletmuskelcapillaren des Menschen bei Arteriosklerose und Diabetes mellitusAN INQUIRY INTO THE PATHOGENESIS, RATIONAL TREATMENT AND PREVENTION OF MULTIPLE SCLEROSIS, WITH EMPHASIS UPON THE COMBINED ROLE OF DIABETOGENIC HYPER-INSULINISM AND RECURRENT EDEMA* 1 December 1965Volume 63, Issue 6Page: 972-987KeywordsDiabetes mellitusEdemaElectron microscopyEmotionsHypoglycemiaMedical servicesOverweightRenal diseasesResearch laboratoriesSurgery Issue Published: 1 December 1965 PDF DownloadLoading ...