tbuckley/cabot-search huggingface dataset:
How to pass exams: evidence-based advice?
Authors: K. Walsh
Journal: Journal of the Royal Society of Medicine (2005)

Erdheim-Chester diseaseDr Lee and his colleagues (April 2005 JRSM 1 ) describe a case of renal failure in which the radiographic appearance of bone pointed to Erdheim-Chester disease, a histiocytosis.Among the organs affected in this condition they mention pericardium.We think it important to emphasize the frequency with which heart, pericardium and great vessels are affected.Recording 6 new patients with cardiovascular involvement, Haroche et al. 2 have reviewed all 178 reported cases of Erdheim-Chester disease.56% had periaortic fibrosis, 44% pericardial infiltration and/or effusions and 31% myocardial infiltration.Interestingly, 6 patients had a right atrial myxoma.Of the 58 patients with follow-up data, 31% died from cardiovascular complications.
The calm after the cytokine storm: lessons from the TGN1412 trial
Authors: E. William St. Clair
Journal: Journal of Clinical Investigation (2008)

In March 2006, a phase I study of the superagonistic anti-CD28 antibody TGN1412 caused a massive cytokine storm and multiorgan failure in six healthy human volunteers. Such a profound impact on the immune system was not predicted by preclinical animal studies. In a study from this issue of the JCI, Müller et al. treated rats with the superagonistic anti-CD28 antibody JJ316 and found that it rapidly induced a marked T cell lymphopenia by trapping T cells in the spleen and lymph nodes (see the related article beginning on page 1405). This dramatic redistribution of T cells simulated the profound T cell lymphopenia observed in human recipients of TGN1412. In contrast, JJ316 treatment in the rats did not reproduce the massive cytokine storm observed following TGN1412 administration to the human volunteers. These results point to similarities as well as differences between rodents and humans in the immunological effects of superagonistic anti-CD28 antibody treatment and raise further questions about how best to design preclinical studies that can better predict the risks of novel immunotherapeutics in humans.
TCTAP A-100 The Restenosis Pattern and Predictor of In-stent-restenosis Ater Zilver PTX Stenting for Superficial Femoral Artery Disease
Authors: Masahiko Fujihara, Makoto Utsunomiya, Yoshiaki Yokoi, Masato Nakamura
Journal: Journal of the American College of Cardiology (2014)
Common sense gun policy reforms for the United States
Authors: K. A. Vittes, J. S. Vernick, D. W. Webster
Journal: BMJ (2012)

In the aftermath of the tragic mass shooting in Newtown, Connecticut, on 14 December—where 20 young children and seven adults, including the perpetrator, were killed—there seems to be a new-found willingness among policy makers and the public to consider common sense gun policy reforms. This is a debate that until now has been conspicuously absent in the United States. Although mass shootings have increased in recent years, the resultant deaths are just the tip of the iceberg. Guns are used to kill about about 86 people in the US each day, and the US has long been an outlier among high income countries in its firearm death rate. This difference is most starkly illustrated by the homicide rate in the US, which is seven times higher than that of 22 other high income nations. The high rate of homicides in the US is driven by a firearm homicide rate that is 20 times higher than in other countries.... Language: en
Pulmonary-Artery Dissection in Patients with Eisenmenger's Syndrome
Authors: Stephen Westaby, Betsy J. Evans, Oliver Ormerod
Journal: New England Journal of Medicine (2007)

To the Editor: Adults with congenital heart disease who have pulmonary hypertension may have dissection of the pulmonary artery. Increasingly recognized as a lethal complication, pulmonary-artery dissection has usually been recorded at autopsy.1 Survivors often receive conservative care, because Eisenmenger's syndrome is deemed inoperable. Heart–lung transplantation has been performed in patients in the chronic phase of the disease.2 However, we suggest that the early, high mortality rate associated with Eisenmenger's syndrome warrants urgent conventional repair of the pulmonary artery. A 26-year-old man with an unrepaired double-outlet right ventricle presented at our center with chest pain and breathlessness. A ventricular septal . . .
The Physician Rebellion
Authors: John E. Kralewski, Bryan E Dowd, Roger D Feldman, Janet Shapiro
Journal: New England Journal of Medicine (1987)

Physicians are becoming increasingly concerned about the controls being placed on their practices by health maintenance organizations (HMOs), preferred-provider organizations, third-party insurance plans, and in some cases, their own group practices. Cost-containment efforts currently have broad social and political support, and physicians are finding that they are no longer the sole decision makers in terms of practice styles. When HMOs and other insurance plans concentrated on the reduction of hospital use and negotiated discounts for hospital services, physicians were concerned but often reluctantly acquiesced, mainly because this process did not directly affect their practices and at times actually helped protect . . .
Can the Learning Health Care System Be Educated With Observational Data?
Authors: Issa J. Dahabreh, David M. Kent
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public Health Dispute
Authors: S. P. J. Kerr, A. Chico, J. L. Thomas, B. R. Pande, M. M. Eustace, M. H. McKeith, A. R. Boon, A. Carruthers, C. Carpenter, J. A. Turpin, E. P. Gilbertson, S. Haigh
Journal: BMJ (1967)
International Antialcohol Congress.
Authors: T. D. Crothers
Journal: JAMA (1907)

Hartford, Conn., Oct. 22, 1907. <h3>To the Editor:</h3> —At the International Antialcoholic Congress, held recently at Stockholm, Sweden, a bureau was established having for its purpose the collection of statistics, papers and documents pertaining to the alcoholic problem from all points of view. This bureau is to be located at Zurich, Switzerland, with Professor Hercord as secretary. This is a similar organization to one formed in Boston last December, called the Scientific Temperance Federation. Both organizations have united, having the same purpose and object, and both are to work conjointly. Documents and papers of one will be transferred or utilized by the other. Both appeal to scientific and philanthropic persons everywhere to assist in the collection of books, papers, studies of every description pertaining to the alcoholic problem. These papers and documents are to be tabulated and arranged so that authors can utilize them in their studies of the subject.
One for the heart
Authors: R. Doll
Journal: BMJ (1997)

“An ounce of whisky, please Sister,” or was it half an ounce or two ounces? I cannot remember now, but I know that I prescribed some tentatively after having sought the ward sister's opinion when I was called to my first patient with lobar pneumonia as a newly qualified house physician in 1937.

There was nothing else to prescribe unless oxygen was needed. In the 19th century alcohol had been prescribed for many debilitating conditions, but its medicinal use was dying out except for people who were terminally ill, and there was certainly no idea that it might be of any use in preventing disease. Some people must have seen Pearl's report in 1926 of a U shaped relation between mortality and the consumption of alcoholic beverages, but it was totally ignored by the medical profession.1

The situation began to change soon after the second world war, with reports of an unusually low prevalence of coronary artery disease in patients found to have cirrhotic livers at necropsy.2 3 Necropsy series were, however, subject to many biases, and these reports excited little interest. Even in the 1970s, when case-control studies of people with and without myocardial infarcts4 and cohort studies of people with different personal characteristics5 began to report a reduced relative risk of myocardial infarction in people who drank small or moderate amounts of alcohol in comparison with non-drinkers, scant attention was paid to them. The belief that alcohol was bad for health was so ingrained that the idea that small amounts might be good for you was hard to envisage, and it is only in the past 10 years that cardiologists and specialists in preventive medicine have begun to take it seriously.

The evidence for a beneficial effect is now massive.3 6 7 It …
Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome
Authors: Alice Norton, Chris Fisher, Hui Liu, Qiang Wen, Gina Mundschau, Jose Luis Fuster, Henrik Hasle, Bernward Zeller, David K. Webb, Aengus O'Marcaigh, April Sorrell, Joanne Hilden, Alan Gamis, John D. Crispino, Paresh Vyas
Journal: Blood (2007)
Abstract LB-185: Decreased LINE-1 methylation in peripheral blood is associated with breast cancer risk in the Sister Study
Authors: Sophia CE. Bolick, Zongli Xu, Lisa DeRoo, Dale P. Sandler, Jack A. Taylor
Journal: Cancer Research (2010)

Abstract Discussion Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-185.
Recent Developments in Multiple Myeloma.
Authors: D. R. Korst
Journal: Annals of Internal Medicine (1962)

s1 April 1962Recent Developments in Multiple Myeloma.D. R. Korst, M.D. (Assoc.), E. P. Frenkel, M.D. (Assoc.)D. R. Korst, M.D. (Assoc.)Search for more papers by this author, E. P. Frenkel, M.D. (Assoc.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-694_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThree rather important developments in the study and treatment of plasmocytic myeloma have occurred in the past three years. These are an experimental animal tumor with all the characteristics of the human myeloma; refined techniques to study abnormal myeloma proteins of serum and urine by filter paper, starch gel, and immunoelectrophoresis; and the clinical trial of a new alkylating agent, cyclophosphamide (Cytoxan) in human cases.A mouse myeloma tumor produces a plasmocytic tumor, bone marrow and spleen involvement, and a typical myeloma electrophoretic pattern at 60 days after inoculation. Resection of the mass of tumor causes a decrease (day 64)... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Mich. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 694-694KeywordsElectrophoretic techniquesImmunoelectrophoresisInoculationMultiple myelomaMyelomaSerum proteinsSpleenStarchesTumor resectionUrine Issue Published: 1 April 1962 PDF DownloadLoading ...
Effect of HIV Infection on Response to Syphilis
Authors: Wafaa El-Sadr, Robin Flam
Journal: Annals of Internal Medicine (1993)

Letters1 October 1993Effect of HIV Infection on Response to SyphilisWafaa El-Sadr, MD and Robin Flam, MDWafaa El-Sadr, MDSearch for more papers by this author and Robin Flam, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-7_Part_1-199310010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Gourevitch and colleagues [1] have made a major contribution to our understanding of human immunodeficiency virus (HIV) infection and syphilis in intravenous drug users. Several case reports have suggested an increased incidence of neurosyphilis in the HIV era and that HIV infection or its associated immunosuppression may modify the presentation of syphilis, its rate of progression, and its response to standard treatment. Musher and coworkers [2] reviewed the literature and concluded that one dose of benzathine penicillin may not be adequate treatment for primary, secondary, and early latent syphilis in HIV-infected patients.The authors suggest in their ...References1. Gourevitch MN, Selwyn PA, Davenny K, Buono D, Schoenbaum EE, Klein RS, et al. Effects of HIV infection on the serologic manifestations and response to treatment of syphilis in intravenous drug users. Ann Intern Med. 1993; 118:350-5. Google Scholar2. Musher DM, Hamill RJ, Baughn RE. Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment. Ann Intern Med. 1990; 113:872-81. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byManagement of syphilis in HIV-positive individuals 1 October 1993Volume 119, Issue 7_Part_1Page: 635-636KeywordsAddictsHIVHIV infectionsHIV-1PenicillinProspective studiesSyphilis ePublished: 15 August 2000 Issue Published: 1 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Putting Antibiotic Prescribing for Children Into Context
Authors: Jonathan A. Finkelstein
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Borderlines: Problems of Self and Object Separation
Authors: Miguel A. Leibovich
Journal: Psychotherapy and Psychosomatics (1976)

The borderline has deficiencies in the capacity to maintain stable self and object representations and in establishing '<i>emotional separateness</i>' from others. In order to create and maintain a '<i>propitious treatment situation</i>' and a '<i>therapeutic alliance</i>' the therapist must work with unusual sensitivity and repetitiveness on the ground rules of the therapeutic environment. Explicit clarifications of the therapist's usual constructive attitudes, as a caring, responsive, neutral and real person must be continuously emphasized. The intense psychotic transference potential that leads to therapeutic complications and disruptions can be worked through, if recognized early, through countertransference clues, acceptance of positive aspects of the countertransference and technical moves that enhance the patient's <i>capacity for individuation and separation</i>, all this within the framework of a structured and consistent therapeutic situation. These assertions are illustrated by specific instances from treatment processes.
Dads, Docs, Drugs, and Decisions
Authors: Stuart Oserman
Journal: JAMA (1992)

the Editor.  —In regard to Is There a Doctor in the House? 1 I wish to comment on the authors' statement on prescription of narcotic or controlled drugs by practitioners to themselves: To the best of our knowledge, American regulatory agencies do not constrain physicians in this way.  Self-prescribing of controlled substances is indeed prohibited in some states. 2 Furthermore, some pharmacists believe that physicians are not acting in the usual course of professional practice when they are treating themselves, and thus a self-prescribed prescription is not valid. 2   Prescriptions for immediate family members may fall into a poorly explored area of inquiry, but self-prescibing controlled substances is prohibited in many jurisdictions.
Foundation trusts argue they really do make a difference
Authors: Lynn Eaton
Journal: BMJ (2005)

Foundation trusts have joined forces to publish details of their achievements in the first 18 months of their existence. And the overview they give is a positive picture of innovation and achievement. The report, published under the auspices of the NHS Confederation, highlights the fact that foundation trusts have had greater freedom to raise money than their counterparts, the non-foundation trusts, and they have made good use of that freedom. Compiled by the 32 foundation trusts, which make up the Foundation Trust Network, the report claims to show “how foundation trusts have improved health care for the communities they serve.” Among the examples of improved services the report cites:
Tumor-Infiltrating Dendritic Cell Subsets of Progressive or Regressive Tumors Induce Suppressive or Protective Immune Responses
Authors: Yongqing Liu, Xuguang Bi, Shulin Xu, Jim Xiang
Journal: Cancer Research (2005)

Abstract Tumor-infiltrating dendritic cells (TID) have an ambivalent role in regulation of tumor regression or growth. However, their precise natures and molecular mechanisms have not been elucidated. In this study, we studied TIDs recruited in progressive P815 and regressive P198 tumors of the same origin. Our data showed that P815 tumors contained CD4+8+ and CD4−8− TID815 subsets, whereas P198 tumors contained CD4+8+ and CD4+8− TID198 subsets. They similarly stimulate allogeneic T cell proliferation and have nitric oxide–mediated cytotoxicity to tumor cells with an exception of CD4−8− TID815 with less efficiency. The newly identified fourth CD4+8+ TID815 or TID198 subset and the CD4+8− TID198 all express high levels of IFN-γ and interleukin (IL)-6, whereas CD4−8− TID815 secrete a marked level of transforming growth factor-β. Vaccination of mice with P815 tumor lysate–pulsed CD4+8+ TID815 or TID198 and CD4+8− TID198 induced IFN-γ–secreting Th1 and effective CTL responses leading to protective immunity against P815 tumor, whereas CD4−8− TID815 stimulated IL-10–expressing Tr1 responses leading to immune suppression. Transfer of CD4+ Tr1 cells obtained from CD4−8− TID815-immunized wild-type, but not IL-10−/− mice, into CD4+8+ TID815 immunized mice abolished otherwise inevitable development of antitumor immunity. Taken together, our findings provide an important insight into immunologic alterations in progressive and regressive tumors and an implication for dendritic cell–based approaches in the design of cancer vaccines.
Fixed minidose warfarin: a new approach to prophylaxis against venous thrombosis after major surgery.
Authors: L Poller, A McKernan, J M Thomson, M Elstein, P J Hirsch, J B Jones
Journal: BMJ (1987)

A prospective study was carried out to see whether a small fixed dose of warfarin (1 mg daily) given before operation (mean 20 days) would prevent deep vein thrombosis in patients having major gynaecological surgery. One hundred and four patients were randomised into three groups: fixed minidose warfarin; full dose oral anticoagulation; and no treatment (controls). There was a significantly lower incidence of deep vein thrombosis in the minidose warfarin and full dose anticoagulant treatment groups (9% (3/32) and 3% (1/35) respectively) than in the controls (30%; 11/37) but no significant difference between the two anticoagulant treatment groups. Prothrombin time and the activated partial thromboplastin time were normal on the day of surgery in the warfarin treatment group, whereas times were prolonged in the group given full dose anticoagulation. Mean haemoglobin concentrations fell in all three groups after operation but the fall was significantly less in the minidose warfarin treatment group than after full dose anticoagulation. The benefit from full dose oral anticoagulant prophylaxis, based on a preoperative international normalised ratio of 1.5-2.5 with rabbit brain Manchester reagent, was similar to the protection achieved in an oral anticoagulant treatment group controlled with human brain Manchester comparative reagent at a similar level of anticoagulation. The lack of disturbance of normal haemostasis at the time of operation together with a significant reduction in deep vein thrombosis may encourage surgeons to introduce minidose prophylaxis with warfarin.
A phase 2 trial of azacitidine and gemtuzumab ozogamicin therapy in older patients with acute myeloid leukemia
Authors: Sucha Nand, Megan Othus, John E. Godwin, Cheryl L. Willman, Thomas H. Norwood, Dianna S. Howard, Steven E. Coutre, Harry P. Erba, Frederick R. Appelbaum
Journal: Blood (2013)
TCT-205 One year outcomes of percutaneous coronary intervention with a modern drug-eluting stent in patients with moderate and severe coronary calcification: A pooled analysis from the Nobori-2 and e-Nobori all-comer registries
Authors: Gert Richardt, Mohamed El-Mawardy, Dmitriy S. Sulimov, Mohamed Abdel-Wahab
Journal: Journal of the American College of Cardiology (2013)
Unexpected Pulmonary Clumping of In-111 Leukocytes Attributable to Indium Oxine Reagent
Authors: PAUL J. BOHDIEWICZ, DARLENE FINK-BENNETT, CONRAD NAGLE, REZA ABGHARI, ROBERT GUTKOWSKI, HOWARD J. DWORKIN
Journal: Clinical Nuclear Medicine (1993)

Five cases of artifactual In-111 leukocyte pulmonary activity were noted at three local hospitals in a 4-day period. Based on the differences in the preparation of the final indium leukocyte product, the problem could be attributed to the indium oxine reagent in a specific lot. This artifact of multiple small foci of marked increased activity in the lungs (clumping pattern), attributable to the In-111 oxine reagent, has not been described previously.
What Role for the Diagnostic Pathologist?
Authors: Merle A. Legg
Journal: New England Journal of Medicine (1981)

Elsewhere in this issue, Schwartz, Wolfe, and Pauker1 tackle the problem of the equivocal pathological diagnosis, specifically with reference to diagnostic biopsies. As the authors do not hesitate to point out, it is a frustrating experience for the clinician to obtain a biopsy in the hope of receiving a precise pathological diagnosis and to receive instead a diffuse statement of circumstances. Nevertheless, it would be dangerous for a pathologist pushed by a desire for specific answers to return a report that was more specific than the evidence warranted. Communication between pathologists and clinicians must be improved so that there is . . .