Myonecrosis and Myofibrosis in Sickle Cell Anemia
Authors: Joseph Mattana, Pravin C. Singhal
Journal: Annals of Internal Medicine (1991)

Letters15 November 1991Myonecrosis and Myofibrosis in Sickle Cell AnemiaJoseph Mattana, MD, Pravin C. Singhal, MDJoseph Mattana, MDSearch for more papers by this author, Pravin C. Singhal, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-10-830 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Valeriano-Marcet and Kerr (1) report myonecrosis and myofibrosis in four patients with painful crises of sickle cell disease. Presumably, sickling of red blood cells causes muscle ischemia and infarction, which account for the musculoskeletal pain that patients with sickle cell disease experience.Creatine kinase is a major biochemical marker of muscle-cell injury; however, the investigators reported a creatine kinase value for only one of their patients. This patient showed only a mildly elevated creatine kinase level, which is not what one would expect in the setting of significant myonecrosis and which easily could have been a consequence...References1. Valeriano-Marcet J and Kerr L. Myonecrosis and myofibrosis as complications of sickle cell anemia. Ann Intern Med. 1991;115:99-101. LinkGoogle Scholar2. Singhal P, Venkatesan J, Gibbons N, and Gibbons J. Prevalence and predictors of rhabdomyolysis in patients with hypokalemia. N Engl J Med. 1990;323:1488. CrossrefMedlineGoogle Scholar3. Singhal P, Abramovici M, and Venkatesan J. Rhabdomyolysis in the hyperosmolal state. Am J Med. 1990;88:9-12. CrossrefMedlineGoogle Scholar4. Singhal P, Barth R, Ginsberg N, and Lynn R. Determinants of serum creatine kinase activity in dialysis patients. Am J Nephrol. 1988;8:220-4. CrossrefMedlineGoogle Scholar5. Wong E, Cobb C, Umehara M, Wolff G, Haywood L, and Greenberg T. Heterogeneity of serum creatine kinase activity among racial and gender groups of the population. Am J Clin Pathol. 1983;79:582-6. CrossrefMedlineGoogle Scholar1. Valeriano-Marcet J and Kerr L. Myonecrosis and myofibrosis as complications of sickle cell anemia. Ann Intern Med. 1991;115:99-101. LinkGoogle Scholar2. Grob D. Rhabdomyolysis and drug-related myopathies. Current Opinion in Rheumatology. 1991;2:908-15. CrossrefGoogle Scholar3. Aberfeld D, Bienenstock H, Shapiro M, Namba T, and Grob D. Diffuse myopathy related to meperidine addiction in a mother and daughter. Arch Neurol. 1968;19:384-8. CrossrefMedlineGoogle Scholar4. Parks D, Perry H, and Muller S. Cutaneous complications of pentazocine injections. Arch Dermatol. 1971;104:231-5. CrossrefMedlineGoogle Scholar5. Lohr K. Rheumatic manifestations of diseases associated with substance abuse. Semin Arthritis Rheumatism. 1987;17:90-9. CrossrefMedlineGoogle Scholar1. Valeriano-Marcet J and Kerr L. Myonecrosis and myofibrosis as complications of sickle cell anemia. Ann Intern Med. 1991;115:99-101. LinkGoogle Scholar2. Aberfeld D, Bienenstock H, Shapiro M, Namba T, and Grob D. Diffuse myopathy related to meperidine addiction in a mother and daughter. Arch Neurol. 1968;19:384-8. CrossrefMedlineGoogle Scholar3. Steiner J, Winkleman A, and DeJesus P. Pentazocine-induced myopathy. Arch Neurol. 1973;28:408-9. CrossrefMedlineGoogle Scholar4. Levin B and Engel W. Iatrogenic muscle fibrosis. Arm levitation as an initial sign. JAMA. 1975;234:621-4. CrossrefMedlineGoogle Scholar5. DeLateur B and Halliday W. Pentazocine fibrous myopathy: report of two cases and literature review. Arch Phys Med Rehabil. 1978;59:394-7. MedlineGoogle Scholar1. Aberfeld D, Bienenstock H, Shapiro M, Namba T, and Grob D. Diffuse myopathy related to meperidine addiction in a mother and daughter. Arch Neurol. 1968;19:384-8. CrossrefMedlineGoogle Scholar2. Delateur B and Halliday W. Pentazocine fibrous myopathy: report of two cases and literature review. Arch Phys Med Rehabil. 1978;59:394-7. MedlineGoogle Scholar3. Valeriano-Marcet J and Kerr L. Myonecrosis and myofibrosis as complications of sickle cell anemia. Ann Intern Med. 1991;115:99-101. LinkGoogle Scholar4. Dorwart B and Gabuzda T. Symmetric myositis and fasciitis: a complication of sickle cell anemia during vaso-occlusion. J Rheumatol. 1985;12:590-5. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Joseph Mattana, MD; Pravin C. Singhal, MDAffiliations: Long Island Jewish Medical Center New Hyde Park, NY 11042 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySickle myonecrosis revisited 15 November 1991Volume 115, Issue 10Page: 830-831KeywordsAnemiaBiomarkersCreatine kinaseInfarctionIschemiaMuscle cellsMyalgiaRed blood cellsSickle cell disease ePublished: 1 December 2008 Issue Published: 15 November 1991 PDF downloadLoading ...