Constitutional Hyperbilirubinemia with Unconjugated Bilirubin in the Serum and Lipochrome-like Pigment Granules in the Liver
Authors: UFFE SAGILD
Journal: Annals of Internal Medicine (1962)

Case Reports1 February 1962Constitutional Hyperbilirubinemia with Unconjugated Bilirubin in the Serum and Lipochrome-like Pigment Granules in the LiverUFFE SAGILD, M.D., OLE Z. DALGAARD, M.D., NIELS TYGSTRUP, M.D.UFFE SAGILD, M.D.Search for more papers by this author, OLE Z. DALGAARD, M.D.Search for more papers by this author, NIELS TYGSTRUP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-308 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral syndromes of constitutional hyperbilirubinemia, caused by deficiencies in the elimination of bilirubin by the liver, have been described (1). Some of these may be diagnosed from their clinical course (2-4), while others can be differentiated only on the basis of laboratory findings. Thus the Gilbert-Meulengracht syndrome (5) [constitutional hepatic dysfunction], the Dubin-Johnson syndrome (6) [chronic idiopathic jaundice], and the Rotor syndrome (7) [chronic familial non-hemolytic jaundice with conjugated bilirubin in the serum] may appear to be identical clinically.The case presented here demonstrates that pathologic findings considered to be typical of different syndromes may be found in the same...References1. ARIAS IM: Recent advances in the metabolism of bilirubin and their clinical implications. Med. Clin. N. Amer. 44: 607, 1960. CrossrefGoogle Scholar2. CRIGLERNAJJAR JFVA: Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics 10: 169, 1952. MedlineGoogle Scholar3. SUMMERSKILLWALSHE WHJM: Benign recurrent intrahepatic "obstructive" jaundice. Lancet 2: 686, 1959. CrossrefMedlineGoogle Scholar4. TYGSTRUP N: Intermittent possibly familial intrahepatic cholestatic jaundice. Lancet 1: 1171, 1960. CrossrefMedlineGoogle Scholar5. 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