tbuckley/cabot-search huggingface dataset:
Peroneal Muscular Atrophy with Mental Defect and Myopathy in Siblings
Authors: R. Gibson
Journal: BMJ (1956)

BAD GASTRECTOMIESMEDIBLRNAL 1281 reconstruction which must follow the ablation, and which demands of the surgeon a special sympathy with the object of his work.Chronic Gastritis and End-results Although this article deals with technique and end-results, reference should be made to chronic gastritis, because it has this in common with the technical niceties, that end-results are jeopardized by neglecting its importance.In patients with ulcer the symptoms come from (1) the ulcer; (2) the diffuse gastro-duodenitis which so often accompanies ulcer, especially gastric, and sometimes simu- lates it; and (3) the mind of the patient.Many physicians and surgeons have failed to understand the fundamental importance of chronic gastro-duodenitis in diseases of the stomach and duodenum.This failure is due to the fact that thev have relied upon the naked eye, either direct or through the gastroscope, for the diagnosis, not realizing that the disease is essentially microscopical.The disease may rilin the health or take the life of the patient and still remain imperceptible to the naked eye.These clinicians have falsely argued that the changes indicating chronic gastritis (the excessive cellular infiltration, with deformity and destruc ion of the epithclial and glandular elements) may be present without symptoms and are therefore with- out significance.The same argument could be applied to carcinoma in many organs, to ulcer, to gall-stones.and to chronic nephritis.Such a defective comprehension of gastric diseases leads in some cases to faulty selection, and in others to post-operative disappointment, because the symptoms due to diffuse chronic gastro-duodenitis may not disappear after operation.
EG-06 * IDH1-MUTATION-ASSOCIATED LONG NON-CODING RNA EXPRESSION CHANGES IN GLIOMA
Authors: G. K. K. Leung, X.-q. Zhang, K. K. Y. Kiang
Journal: Neuro-Oncology (2014)

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutation is a frequent event in low-grade gliomas as well as secondary glioblastomas. Mutated IDH1 can induce genome-wide transcriptional alterations that may contribute to gliomagenesis. Long non-coding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis in a number of neoplastic conditions including glioma. Our previous works suggested that aberrant expressions of specific lncRNAs may play important roles in tumor initiation and progression.1 In the present study, we further investigated changes in lncRNA expression profile associated with IDH1 mutation. METHODS: We performed lncRNA profiling analysis of publicly available glioma microarray data using our previously reported mining approach. We compared the differential lncRNA expression profiles between mutant-type and wild-type IDH1 samples in both glioblastoma and oligodendroglioma. RESULTS: We identified distinct sets of dysregulated lncRNAs that were associated with IDH1 mutation in glioblastomas and oligodendrogliomas. Hierarchical clustering revealed that IDH1-mutant tumors clustered together and were clearly distinguishable from IDH1-wild-type samples. Interestingly, glioblastoma and oligodendroglioma also shared a specific set of lncRNA alterations, suggesting common and early transcriptional alterations. We also found that IDH1-mutation-associated lncRNA alterations exhibited a tumor grade-dependent pattern that was associated with differences in clinical outcomes. CONCLUSION: The identification of IDH1-mutation-associated lncRNAs provided further evidence in support of the important roles of lncRNA in glioma pathogenesis. The approach may improve the understanding of the pathogenesis of gliomas with different IDH1 gene mutation status. References: 1. Zhang X, Sun S, Lam KF, Kiang KMY, Pu JKS, Ho ASW, Lui WM, Gung CF, Leung GKK. A long non-coding RNA signature in glioblastoma multiforme predicts survival.
The Physician's Assistant
Authors: REIN TIDEIKSAAR
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 September 1983The Physician's AssistantREIN TIDEIKSAAR, P.A., PH.D.REIN TIDEIKSAAR, P.A., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-3-416_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In view of the Graduate Medical Education National Advisory Committee (GMENAC) report that this country will have a surplus of primary care physicians, Cawley and associates (1) present a timely discussion on the alternative employment possibilities for physician's assistants. As the authors state, geriatrics will be one of the areas for use of physician's assistants in the future. Unfortunately, in describing the role of physician's assistants in geriatrics the authors fail to clarify several issues concerning their use as care providers for geriatric patients.The first issue is that of cost. It is not that physician's assistants...Reference1. CAWLEYOTTDEATLEY JJC. The future for physician assistants. Ann Intern Med. 1983;98:993-97. LinkGoogle Scholar1. CAWLEYOTTDEATLEY JJC. The future for physician assistants. Ann Intern Med. 1983;98:993-7. LinkGoogle Scholar2. TARLOV A. Academic general internal medicine. Ann Intern Med. 1982;96:239-40. LinkGoogle Scholar3. PLESS I. Implementing research findings: who is responsible? Can Med Assoc J. 1982;126:345-6. MedlineGoogle Scholar4. LEHOTAYDUGASLEVEY DMG. A program for training physician-investigators. J Med Educ. 1982;57:602-8. MedlineGoogle Scholar1. CAWLEYOTTDEATLEY JJC. The future of physician assistants. Ann Intern Med. 1983;98:993-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: One Jefferson Avenue, D7; Rockville Centre, NY 11570 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1983Volume 99, Issue 3Page: 416-416KeywordsForecastingGeriatricsGraduate medical educationPrimary care physicians Issue Published: 1 September 1983 PDF downloadLoading ...
Depressives, Doctors, and Antidepressants
Authors: E. H. Uhlenhuth
Journal: JAMA (1982)

Keller and colleagues, in their article in this issue ofThe Journal(see p 1848), assert that depression is undertreated and mistreated in the community. They suggest that the public and the medical profession are poorly informed about the treatments available for depression. They call for further research into the inappropriate behavior of patients and physicians, with a view toward providing corrective education for a prompt solution of this important public health problem. It is tempting to question the validity of the information available on the treatment of depression in the community by entering on a detailed critique of the methodological limitations of recent studies, particularly in the selection of samples and the identification of cases within these samples. Because the data of various flawed studies tend to converge, however, such criticism may be largely ritualistic. It is perhaps more useful here to consider some implications of the data. The
The Isoprostanes
Authors: Jason D. Morrow, L. Jackson Roberts
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Section:ChooseTop of pageAbstract <<MECHANISM OF FORMATION OF...QUANTIFICATION OF F2-ISOP...ISOPROSTANE FORMATION IN ...MEASUREMENT OF THE MAJOR ...QUANTIFICATION OF ISOPROS...FORMATION OF ISOPROSTANES...QUANTIFICATION OF F2-ISOP...ISOPROSTANE FORMATION IN ...ISOPROSTANE FORMATION IN ...ISOPROSTANE FORMATION IN ...ReferencesCITING ARTICLES
Improving survival after large bowel cancer.
Authors: S Whitaker
Journal: BMJ (1991)

Pneumothorax after fine needle aspiration of the breast SIR,-We are not surprised by Mr C A Gateley and colleagues' report of pneumothorax as a complication of fine needle aspiration of the breast.'We note that the authors are unaware of previous reports of this complication.In fact, the incidence of this complication was reported as 0 18% in a large Italian series of 74 000 fine needle aspirations of the breast,2 and there have been several isolated case reports.34Seven months ago we unsuccessfully submitted to the BMJ a report describing this complication in a young thin woman referred to the accident and emergency department in the evening by her general practitioner.She had complained of pleuritic chest pain and dyspnoea since fine needle aspiration of a benign breast lesion at the surgical outpatient department earlier that day.We agree with Mr Gateley and colleagues that workers other than those actually performing the procedure must be aware of the hazards, however rare.This is particularly true for general practi- tioners and those working in accident and emergency departments, who may be presented with this delayed complication after the outpatient clinics are closed and those working in them have long gone home.
Abstract 3412: Imaging of methioninase-induced S/G2-phase-trapping for subsequent effective chemotherapy.
Authors: Shuya Yano, Yasunori Tome, Michelle Digman, Masashi Momiyama, Atsushi Suetsugu, Enrico Gratton, Robert M. Hoffman
Journal: Cancer Research (2013)

Abstract Methionine-dependence of cancer cells may be due to excessive methylation reactions in cancer cells. Deprivation of methionine α,γ lyase (methioninase or METase) selectively arrests cancer cells during late S-phase, where they are highly sensitive to DNA-damaging chemotherapy. Fluorescent ubiquitination-based cell cycle indicator (FUCCI)), was used to monitor the onset of the S/G2-phase block due to methionine deprivation effected by METase. The S-phase-blocked cancer cells fluoresced yellow or green, in contrast to cancer cells in G1 which fluoresced red. Cancer cells, synchronously blocked in S-phase by METase and identified by their yellow-green fluorescence, were administered DNA-damaging chemotherapy drugs such as doxorubicin, cisplatin, or 5-fluorouracil. Treatment of cancer cells with drugs only without methioninase-effected S-phase synchrony, led to the majority of the cancer cell population being blocked in G0/G1 phase (red fluorescent) where they were resistant to the drugs. In contrast, METase treatment, followed by chemotherapy when FUCCI indicated the S/G2 block was highly effective for killing cancer cells. Color-coded chemotherapy, whereby the cell cycle of cancer cells is selectively and synchronously blocked in S-phase as identified by fluorescent reporters, may be a general approach to effective cancer treatment. Citation Format: Shuya Yano, Yasunori Tome, Michelle Digman, Masashi Momiyama, Atsushi Suetsugu, Enrico Gratton, Robert M. Hoffman. Imaging of methioninase-induced S/G2-phase-trapping for subsequent effective chemotherapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3412. doi:10.1158/1538-7445.AM2013-3412
Bronchial hyperresponsiveness in children with atopic rhinitis: a 7‐year follow‐up
Authors: F. Cibella, G. Cuttitta, S. La Grutta, M. R. Hopps, G. Passalacqua, G. B. Pajno, G. Bonsignore
Journal: Allergy (2004)

A high prevalence of bronchial hyperresponsiveness (BHR) was found in atopic subjects with rhinitis. Those subjects may be at higher risk for developing bronchial asthma. We evaluated, in a 7-year follow-up, BHR and atopy in a homogeneous population of nonasthmatic children with allergic rhinitis (AR), and their role in asthma development.Twenty-eight children (6-15 years) with AR were studied. At enrollment (T(0)), skin tests, total serum IgE assay, peak expiratory flow (PEF) monitoring and methacholine (Mch) bronchial challenge were performed. BHR was computed as the Mch dose causing a 20% forced expiratory volume (FEV)(1) fall (PD(20)FEV(1)) and as dose-response slope (D(RS)). Subjects were reassessed after 7 years (T(1)) using the same criteria.At T(0), 13 children (46%), showing a PD(20)FEV(1) <1526 microg of Mch, had BHR (Mch+), although PEF variability (PEFv) was within normal limits. None of the children with negative methacholine test developed bronchial asthma after 7 years. Of the 13 Mch+, only two reported asthma symptoms after 7 years. No significant change was seen in the other parameters of atopy considered.Children with allergic rhinitis present a high prevalence of BHR. Nevertheless, their PEFv is normal and the rate of asthma development low.
Computer assisted learning in undergraduate medical education
Authors: T. Greenhalgh
Journal: BMJ (2001)

It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of online options illustrated in the figure must surely make learning more exciting, effective, and likely to be retained. This assumption is potentially but by no means inevitably correct. ### Box 1: Why fund computer assisted learning? Computer assisted learning is inevitable —Individual lecturers and departments are already beginning to introduce a wide range of computer based applications, sometimes in a haphazard way. Planned and coordinated development is better than indiscriminate expansion It is convenient and flexible —Courses supported by computer assisted learning applications may require fewer face to face lectures and seminars and place fewer geographical and temporal constraints on staff and students. Students at peripheral hospitals or primary care centres may benefit in particular Unique presentational benefits —Computer presentation is particularly suited to subjects that are visually intensive, detail oriented, and difficult to conceptualise, such as complex biochemical processes or microscopic images.1 Furthermore, “virtual” cases may reduce the need to use animal or human tissue in learning Personalised learning —Each learner can progress at his or her preferred pace. They can repeat, interrupt, and resume at will, which may have particular advantages for weaker students Economies of scale —Once an application has been set up, the incremental cost of offering it to additional students is relatively small Competitive advantage —Potential applicants may use the quality of information technology to discriminate between medical schools. A “leading edge” virtual campus is likely to attract good students Achieves the ultimate goal of higher education —The goal is to link people into learning communities. Computer applications, especially the internet and world wide web, are an extremely efficient way of doing this2 Expands pedagogical horizons —The most controversial argument for … RETURN TO TEXT
The Impact of Concomitant Percutaneous Coronary Intervention in High-Risk Patients with Aortic Stenosis and Coronary Artery Disease on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation
Authors: Ömer Aktug, Ralf Herpertz, Kathrin Brehmer, Rüdiger Autschbach, Nikolaus Marx, Shahram Lotfi, Rainer Hoffmann
Journal: Journal of the American College of Cardiology (2013)
Surgeon who pleads guilty to two charges of manslaughter and 21 of causing harm gets four years in prison
Authors: N. Stafford
Journal: BMJ (2011)

A surgeon in Germany who removed healthy body organs and made other medical mistakes resulting in the deaths of four patients has been sentenced to four years in prison to be followed by a four year ban on practising medicine.

In a plea bargain arrangement, Arnold Pier, 54, pleaded guilty in the district court in Monchengladbach to two counts of involuntary manslaughter and 21 counts of causing bodily harm. His sentence, to be served at a minimum security prison, could end up being much less than four years …
Water Fluoridation and Hip Fracture
Authors: Cyrus Cooper
Journal: JAMA (1991)

<h3>To the Editor.</h3> — In a recent article inThe Journal, Jacobsen et al<sup>1</sup>demonstrated a positive ecologic association between hip fracture discharge rates in the United States and fluoride content in water supplies. In a similar study, we recently reported the ecological association of discharge rates for hip fracture and water fluoride levels in 39 county districts in England.<sup>2</sup>Our study was performed in response to the suggestion that fluoridation of water might serve to stem the rising tide of hip fracture in western populations. Such a strategy was supported by laboratory evidence that fluoride was a potent inducer of bone formation, and by epidemiologic studies from Finland and the United States demonstrating lower rates of hip fractures associated with higher water fluoride levels. Our analysis demonstrated no significant association between discharge rate and total fluoride concentration (<i>r</i>=.16,<i>P</i>=.34). This lack of association was found
Sustained platelet GP IIb/IIIa blockade with oral orbofiban: interim safety and tolerability results of the SOAR study
Authors: P.C. Deedwania, J.J. Farguson, D.J. Kerelakes, D. Fitzgerald, R.J. Anders, D.M. Burns, B.S. Bryzinski
Journal: Journal of the American College of Cardiology (1998)
MYRINGITIS ACUTA—MYRINGITIS BULLOSA.
Authors: FRANK ALLPORT
Journal: JAMA (1896)

Miss M. C., age 20; left ear; general health not good; has had naso-pharyngeal colds for two or three weeks, accompanied by a hard cough. Nov. 11,1895, at about 11 P.M., experienced suddenly a severe earache, which continued with increasing severity till the morning of November 12, when I was consulted. I found the view of the membrana tympanum obstructed by three large bullæ situated as follows: One at the upper anterior quadrant, extending down nearly to the inferior extremity of the handle of the malleus. This was large and deeply congested, the redness passing on to the meatal wall, as it joins the drum-head. Another was situated at the junction of the drum-head with the posterior meatal wall, and was more on the latter than the former. This was also much inflamed and large. Another blister occurred exactly at the inferior extremity of the malleus, and was smaller than
Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis
Authors: F D O’Shea, E Boyle, R Riarh, S M Tse, R M Laxer, R D Inman
Journal: Annals of the Rheumatic Diseases (2008)

Objectives: An important unresolved issue in the pathogenesis and clinical course of ankylosing spondylitis (AS) is whether juvenile-onset AS (JoAS) is a clinical entity in its own right or just an earlier onset variant of adult-onset AS (AoAS). A study was undertaken to address this issue. Methods: All patients with AS were extracted from the database of a large spondylitis clinic. Those with symptom onset at ⩽16 years were compared with those with symptom onset at ⩾17 years. Odds ratios (OR) were calculated and adjusted for disease duration and current age. Results: 267 patients with AS were identified; 84 met the criteria for JoAS and 183 met the criteria for AoAS. There were no differences in gender ratio (male: JoAS 81%, AoAS 79%) or in HLA-B27 status (positive: JoAS 75%, AoAS 81%). The axial/peripheral pattern of disease at presentation differed; an exclusively peripheral pattern was seen in 26% with JoAS but in only 4.6% of those with AoAS (p&lt;0.001). There were no differences in disease activity between the two groups. When adjusted for disease duration, axial features were more prominent in AoAS than JoAS as represented by neck pain (OR 2.93 (95% CI 1.54 to 5.55)), neck stiffness (OR 3.39 (95% CI 1.80 to 6.39)), back pain (OR 2.96 (95% CI 1.43 to 6.11)) or back stiffness (OR 3.30 (95% CI 1.50 to 7.28)). AoAS was associated with worse functional and quality of life measures and higher fatigue scores when adjusted for disease duration. Conclusions: JoAS follows a distinctive clinical course from AoAS. These clinical features are dictated by factors other than male gender and HLA-B27 and warrant further investigation.
The early growth response-1 (EGR-1) gene is critical to reperfusion following acute vascular obstruction: Results from a knockout mouse ischemia model
Authors: Paul Schalch, Ramaswamy Ramchandran, David Y. Kim, Gerald Patejunas, Mauricio A. Retuerto, Jeffrey D. Milbrandt, Ronald G. Crystal, Todd K. Rosengart
Journal: Journal of the American College of Cardiology (2003)
Carcinoma of the Colon and Antecedent Epithelium
Authors: Duane W. Taebel
Journal: JAMA (1971)

Throughout the past few decades most cancer research has been directed towards a more thorough understanding of cellular and tissue biology. A considerable portion of these studies have to do with gastrointestinal epithelium, for this epithelium can be readily studied in the laboratory and also has an inherently high replication rate. The material published in the 26 chapters of this book report the techniques, results, and conclusions of 39 different individuals who have pursued these basic studies. At the same time, the book offers a preliminary report on the way such studies may relate to eventual understanding of colonic carcinoma.  The book is divided into four parts, each with several reports and a concluding chapter summarizing the relationship of the studies to oncogenesis. The first part deals with knowledge regarding the growth of normal and abnormal colonic epithelium. It includes an analysis of current surgical approaches to colonic carcinoma based