tbuckley/cabot-search huggingface dataset:
DIAGNOSTIC VALUE OF THE LEUCOCYTE FORMULA IN PERTUSSIS.
Authors: FRANK SPOONER CHURCHILL
Journal: JAMA (1906)

<h3>IMPORTANCE OF BLOOD EXAMINATION.</h3> Whooping-cough is a far more serious disease than is generally supposed, and its diagnosis in the early stage is a matter of great importance, as it is at this time that the infection is most frequently spread. Any measure, therefore, which may help to its early recognition is worthy of careful study and investigation. The examination of the blood in this disease, as in many other infections, has unexpectedly shown a condition which, in a certain number of cases, is abnormal and perhaps of diagnostic value. This condition consists of an increase, both relative and absolute, in the number of the lymphocytes—a lymphocytosis. Several series of cases have been reported showing this increase in these cells, but the number on record is still comparatively small. Therefore I have made some investigations on this subject with the object of determining how frequently this condition is found, how
Revised Guidelines for Managing Acute MI
Authors: Marsha F. Goldsmith
Journal: JAMA (1997)

THE RECENTLY issued<i>Guidelines for the Management of Patients With Acute Myocardial Infarction</i>(MI) "contain much that is new in terms of the rubric doctors follow," according to Thomas J. Ryan, MD, first author of the new edition. Since the original guidelines were published by the American College of Cardiology (ACC) and American Heart Association (AHA) in 1990, he said at the AHA's annual scientific sessions in New Orleans, La, advances in diagnosis and treatment that have come into practice through an "evidencebased medicine" approach dictated the current revision (published in<i>J Am Coll Cardiol</i>. 1996;94:2341-2350). After reviewing some 5000 US and European publications, many of which included data from controlled clinical trials, members of the guideline committee created the new document, which is written for a multidisciplinary audience. It has been endorsed by the American Association of Critical Care Nurses, American College of Emergency Physicians, and American Society of
Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 2. Hemodynamic and drug disposition studies
Authors: R Mastai, S Laganiere, I R Wanless, L Giroux, B Rocheleau, P Huet
Journal: Hepatology (1996)

We assessed hepatic functions and systemic and splanchnic hemodynamics in a new model of hepatic sinusoidal fibrosis. Fibrosis was induced by the simultaneous administration for 8 weeks of diethyl-stilbestrol (DES) (10 mg twice weekly, subcutaneously) and cholesterol-supplemented diet (1%) in rabbits. A marked and progressive impairment of hepatic function was observed during the 8 weeks of treatment with a significant decrease in indocyanine green (ICG) systemic clearance (-89%; P < .001) and aminopyrine elimination (-69%; P < .001). In fibrotic animals, hyperdynamic circulation was found with an increased cardiac output (+73%, P < 0.01) and a decreased peripheral vascular resistance (-50%; P < .005), as evaluated by the microsphere technique in animals that were awake. The total portal venous inflow was not significantly modified in fibrotic rabbits. However, since there was a marked increase in the liver weight, the portal venous inflow was significantly decreased when expressed per gram of liver weight (-30%; P < .05). In contrast, the hepatic artery blood flow was markedly increased, even when expressed per gram of liver weight (+95%; P < .01). Portal pressure was significantly increased in treated rabbits (from 7.4 +/- .4 to 14.4 +/- .6 mm Hg, P < .01). This new experimental model could prove useful to evaluate the influence of extensive perisinusoidal fibrosis on exchanges between plasma and hepatocytes, particularly of protein-bound substances.
Gastroptosia not Gastroptosis.
Authors: A. Rose
Journal: JAMA (1902)

New York, Aug. 19, 1902. <h3>To the Editor:</h3> —In my letter which appeared in your issue for August 16 I noticed an error which may be either the printer's or my own slip of pen in manuscript. It reads "<i>epi</i>means on, upon or touching," while I wish to say "<i>peri</i>means on, upon or touching." Being prepared to meet opposition—since it is generally believed that "<i>peri</i>" means around only—I ask you to insert this correction. I know some of the Greek dictionaries are not explicit enough in regard to this word, and therefore allow me to say that not only in Greek spoken at present, but also in classical writers peri may distinctly mean "<i>upon</i>." Περ[unk] λεθον τεσέιν (Aristophanes, Acharnians v. 1180). Περ[unk] ν[unk]σον άλώμενοι (Odyssey 4, 368). [Dr. Rose's original letter shows that he was responsible for the error.—Ed.
Reply to V. Pitini et al
Authors: Andreas Hochhaus, Andreas Burchert
Journal: Journal of Clinical Oncology (2010)

We appreciate the comments by Pitini et al highlighting the interesting mechanisms of action of interferon alfa (IFN) that supplement the activity of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia (CML). As monotherapy, IFNinduces heterogeneous responses in CML, with up to 80% of early chronic-phase patients achieving hematologic remission but only 8% to 30% achieving complete cytogenetic remission. Although response correlates with Euro and Sokal risk scores, the molecular basis for heterogeneous responses and indeed more broadly the mechanism of response to IFNremain poorly understood. Recent evidence suggested that IFNmay sensitize dormant stem cells to imatinib-induced apoptosis by inducing their cell cycle entry. This observation, which was discussed in our report, was made using short courses of high-dose IFNfollowed by fluorouracil in a non-CML mouse model. Hematopoietic stem cells (HSCs) respond to IFNtreatment by the increased phosphorylation of STAT1 and PKB/Akt, the expression of IFN target genes, and the upregulation of stem cell antigen-1 (Sca-1). In HSCs lacking the IFN/ receptor, STAT1 and Sca-1 are insensitive to IFN stimulation. Conversely, HSCs chronically activated by IFN are rapidly outcompeted in repopulation assays. Whereas chronic activation of the IFN pathway in HSCs impairs their function, acute IFN treatment promotes the proliferation of dormant HSCs in vivo. The anti-CML mechanism exerted by IFN has classically been linked to the effects on immune cells, including cytotoxic T cells. In our study, patients were predominantly treated with pegylated IFN-2a in low doses, which results in a continuous exposure of normal and neoplastic cells to the drug. Although an additional stem-cell activation effect of permanent IFNadministration cannot be excluded, the effect should have disappeared after chronic administration during maintenance therapy. Thus, for the concept of maintenance therapy with IFNafter tyrosine kinase inhibitor induction, the stimulation effect on cytotoxic T cells is the dominant cause of response, which persists even after discontinuation of all therapy including IFN. Because the model by Essers et al suggests a new mode of action of IFN in cancer therapy, the appropriate demonstration of applicability to CML in vivo is pending. Our data suggest the predominance of an immunophenomenon, which will persist even after discontinuation of IFN. Beginning CML therapy with IFNfollowed by imatinib therapy was tested in the pilot phase of the German CML Study IV. This schedule will be able to test for the stem cell recruiting activity of IFN, which will be used to increase the efficacy of tyrosine kinase inhibitors.
Rate of Decline in Serum PFOA Concentrations after Granular Activated Carbon Filtration at Two Public Water Systems in Ohio and West Virginia
Authors: Scott M. Bartell, Antonia M. Calafat, Christopher Lyu, Kayoko Kato, P. Barry Ryan, Kyle Steenland
Journal: Environmental Health Perspectives (2009)

BackgroundDrinking water in multiple water districts in the Mid-Ohio Valley has been contaminated with perfluorooctanoic acid (PFOA), which was released by a nearby DuPont chemical plant. Two highly contaminated water districts began granular activated carbon filtration in 2007.ObjectivesTo determine the rate of decline in serum PFOA, and its corresponding half-life, during the first year after filtration.MethodsUp to six blood samples were collected from each of 200 participants from May 2007 until August 2008. The primary source of drinking water varied over time for some participants; our analyses were grouped according to water source at baseline in May–June 2007.ResultsFor Lubeck Public Service District customers, the average decrease in serum PFOA concentrations between May–June 2007 and May–August 2008 was 32 ng/mL (26%) for those primarily consuming public water at home (n = 130), and 16 ng/mL (28%) for those primarily consuming bottled water at home (n = 17). For Little Hocking Water Association customers, the average decrease in serum PFOA concentrations between November–December 2007 and May–June 2008 was 39 ng/mL (11%) for consumers of public water (n = 39) and 28 ng/mL (20%) for consumers of bottled water (n = 11). The covariate-adjusted average rate of decrease in serum PFOA concentration after water filtration was 26% per year (95% confidence interval, 25–28% per year).ConclusionsThe observed data are consistent with first-order elimination and a median serum PFOA half-life of 2.3 years. Ongoing follow-up will lead to improved half-life estimation.
Historic Montreal: Metropolis of Canada and Mother of the Cities of the West
Authors: MAUDE E. ABBOTT
Journal: Annals of Internal Medicine (1932)

Article1 December 1932Historic Montreal: Metropolis of Canada and Mother of the Cities of the WestMAUDE E. ABBOTT, B.A., M.D., F.R.C.P.(Can.)MAUDE E. ABBOTT, B.A., M.D., F.R.C.P.(Can.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-6-815 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor the first time in its annals the College is to meet in this beautiful metropolitan city that clusters around the slopes of Mount Royal and extends to east and west below these along the banks of the St. Lawrence as far as eye can reach. Snow-girt she will be then, and sparkling in her winter garment in air tingling with ozone that breathes of those mighty regions beyond, of which she is at once the haven and the gate. For Montreal, the second largest seaport on this continent is the only one that lies 1,000 miles above the ocean...References1 ABBOTT ME: "Medicine and Surgery in the Province of Quebec". In "The Storied Province of Quebec". Edited by William Wood, 1931, ii, 1066-1150. Also: History of Medicine in the Province of Quebec, 1931, 120 pages, 42 illustrations. Published from The Medical Museum of McGill University, Montreal, Canada. Google Scholar2 ATHERTON WH: Metropolitan Montreal. In "The Storied Province of Quebec", Edited by William Wood, 1931, i. 605-622; ii. 623-781. Google Scholar3 LIGHTHALL WD: Montreal after 250 Years. Also, Canad. Antiq. and Numismatic Soc., 1910, iii, 192. Google Scholar4 MASSICOTTE EZ: Les Premiers Chirurgiens de l'Hotel Dieu de Montrèal. Bulletin des Recherches historiques, 1924, p. 400; Also, Les Chirurgiens, Medicins, etc. etc. de Montrèal sous le Régime Francais. Archives de Quebec, 1922-23, 131-155; Also: 3ieme Rapport de l'Archiviste, 1923-24, 163-192. Google Scholar5 MIGNAULT LD: Histoire de l'Ecole de Médecine et de Chirurgie de Montrèal. L'Union Médicale du Canada, 1926, lv, 598. Google Scholar6 ABBOTT ME: An Historical Sketch of the Medical Faculty of McGill University and of the Origin of the School. With Appendix. Montreal Medical Journal, 1902, xxxi, 561-675. Also, Gazette Printing Co., 1902, 114 pages, 30 illustrations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: McGill University Montreal PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1932Volume 6, Issue 6Page: 815-838 ePublished: 1 December 2008 Issue Published: 1 December 1932 PDF downloadLoading ...
Pulmonary arterial pressure and structure in the patas monkey after prolonged administration of aminorex fumarate
Authors: P. SMITH, D. HEATH, J. M. KAY, J. S. WRIGHT, C. S. MCKENDRICK
Journal: Cardiovascular Research (1973)

Journal Article Pulmonary arterial pressure and structure in the patas monkey after prolonged administration of aminorex fumarate Get access PAUL SMITH, PAUL SMITH From the Department of Pathology, University of Liverpool, and the Liverpool Region Cardiac Centre, Sefton General Hospital, Liverpool Search for other works by this author on: Oxford Academic PubMed Google Scholar DONALD HEATH, DONALD HEATH From the Department of Pathology, University of Liverpool, and the Liverpool Region Cardiac Centre, Sefton General Hospital, Liverpool Search for other works by this author on: Oxford Academic PubMed Google Scholar J. M. KAY, J. M. KAY From the Department of Pathology, University of Liverpool, and the Liverpool Region Cardiac Centre, Sefton General Hospital, Liverpool Search for other works by this author on: Oxford Academic PubMed Google Scholar J. S. WRIGHT, J. S. WRIGHT From the Department of Pathology, University of Liverpool, and the Liverpool Region Cardiac Centre, Sefton General Hospital, Liverpool Search for other works by this author on: Oxford Academic PubMed Google Scholar C. S. MCKENDRICK C. S. MCKENDRICK From the Department of Pathology, University of Liverpool, and the Liverpool Region Cardiac Centre, Sefton General Hospital, Liverpool Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 7, Issue 1, January 1973, Pages 30–38, https://doi.org/10.1093/cvr/7.1.30 Published: 01 January 1973
VOLUNTEER MEDICAL SERVICE CORPS
Authors: W. H. Luedde
Journal: JAMA (1918)

<h3>FROM ST. LOUIS</h3><h3>To the Editor:</h3> —As a Fellow of the American Medical Association who takes due pride in the organization, I am constrained to express my regret at the tone of your correspondents' notes and your answer, concerning the Volunteer Medical Service Corps (The Journal, Sept. 7, 1918, p. 845). At any other time, the expression of personal pique against Dr. Franklin H. Martin might be either sublime or ridiculous, according to the point of view. At present, when combined with your attack on the Council of National Defense, it constitutes at least betrayal of the loyal attitude of the membership of the American Medical Association, if it does not actually give aid and comfort to the enemy. You should know that the Volunteer Medical Service Corps was originated to give some degree of recognition to the physicians who must remain at home. We find here that Illinois physicians
Gross and Histological Features of Excised Portions of Posterior Mitral Leaflet in Patients Having Operative Repair of Mitral Valve Prolapse and Comments on the Concept of Missing (= Ruptured) Chordae Tendineae
Authors: William C. Roberts, Travis J. Vowels, Jong M. Ko, Robert F. Hebeler
Journal: Journal of the American College of Cardiology (2013)
Double-outlet right ventricle associated with persistent common atriventricular canal.
Authors: S Sridaromont, R H Feldt, D G Ritter, G D Davis, D C McGoon, J E Edwards
Journal: Circulation (1975)

A variant of double-outlet right ventricle (DORV) associated with common atrioventricular (A-V) canal was identified. As yet, this syndrome has not been successfully repaired. Of 16 patients with this diagnosis, 14 had the diagnosis confirmed at postmortem examination and two had the diagnosis confirmed by exploratory cardiotomy. The 16 patients were divided into two groups according to the position of the cardiac apex: group 1, ten patients with levocardia, and group 2, six patients with dextrocardia and ventricular inverson. When pulmonary stenosis was present, the clinical presentation was similar to that in tetralogy of Fallot, and when such stenosis was not, the presentation was similar to that in ventricular septal defect with bidirectional shunting. The electrocardiogram had the typical feature of common A-V canal. The right ventricular angiocardiogram had features typical of DORV. The left ventricular angiocardiogram revealed left ventricular outflow deformity typical of A-V canal in patients with levocardia but not in those with dextrocardia. Splenic anomalies were commonly seen (nine of the 16 patients). Asplenia was present in seven, and polysplenia in two. Ten patients had persistent left superior vena cava, seven had common atricum, six had anomalous pulmonary venous connection, and three had subaortic stenosis. Twelve of the 16 patients had pulmonary stenosis. Of the 16, 14 had common A-V canal (Rastelli type C) and two had a ventricular septal defect of the persistent common A-V type.
Danazol and Thyroid Function
Authors: ROBERT L. BARBIERI
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 January 1980Danazol and Thyroid FunctionROBERT L. BARBIERI, M.D.ROBERT L. BARBIERI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-133_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent issue Wortsman and associates (1) reported that women receiving 400 to 800 mg of danazol daily have a low thyroxine (T4) index and normal thyrotropin (TSH) levels. They concluded that some women receiving danazol might be hypothyroid. Their observations do not support their conclusion. Detailed analysis of the effects of danazol on thyroid function indices has shown that danazol lowers thyroxine-binding globulin (TBG) capacity, lowers total T4, and produces no change in free T4(hence the normal TSH) (2). One explanation of these thyroid function indices is that the androgenic effects of danazol result...References1. WORTSMANHIRSCHOWITZSOLER JJN. Danazol and thyroid function. Ann Intern Med. 1979;91:321. Letter. LinkGoogle Scholar2. PANNALLMAAS PD. Danazol and thyroid-function tests. Lancet. 1977;1:102. Letter. CrossrefMedlineGoogle Scholar1. TOFTSETHHUNTERIRVINE AJWW. Plasma thyrotrophin and serum thyroxine in patients becoming hypothyroid in the early months after iodine-131. Lancet. 1974;1:704-5. CrossrefMedlineGoogle Scholar2. FLEISHERMCCONAHEYPANKOW GWM. Serum creatine kinase, lactic dehydrogenase, and glutamic-oxalacetic transaminase in thyroid diseases and pregnancy. Mayo Clin Proc. 1965;40:300-11. MedlineGoogle Scholar3. SCARPALEZOSLYGIDAKISPAPAGEORGIOUMALIARAKOUKOULOMMATIKOUTRAS SCCSAD. Neural and muscular manifestations of hypothyroidism. Arch Neurol. 1973;29:140-4. CrossrefMedlineGoogle Scholar4. GOLDMANMATXMORTIMERFREEMAN JRRR. High elevations of creatine phosphokinase in hypothyroidism. JAMA. 1977;238:325-6. CrossrefMedlineGoogle Scholar5. HIRSCHOWITZSOLERWORTSMAN JNJ. Sex steroid levels during treatment of endometriosis. Obstet Gynecol. 1979;54:448-50. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Peter Bent Brigham Hospital Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe use of danazol as a treatment of endometriosisDanazol: Endocrine pharmacology and therapeutic applications 1 January 1980Volume 92, Issue 1Page: 133-134KeywordsGlobulinsThyroidThyroid-stimulating hormoneThyroxine Issue Published: 1 January 1980 PDF DownloadLoading ...
New HER2 Assay Using Trastuzumab for the Selection of Trastuzumab Responding Breast Cancer: The Positivity Is Significantly Associated with Pathologic Complete Response after Preoperative Chemotherapy.
Authors: S. Kim, N. Baek, B. Kwon, Y. Kwon, J. Ro, I. Park, E. Lee
Journal: Cancer Research (2009)

Abstract Background:The evaluation of HER2 status is required for trastuzumab therapy in breast cancer. Although there are a few methods for an evaluation of HER2 status, theoretically the better method would be to check trastuzumab uptake itself in the tumor after trastuzumab administration. Therefore, we developed a different HER2 test (QHerceptest) using trastuzumab to improve an accuracy in the selection of patient for trastuzumab therapy.Patients and Methods:31 patients with HER2 positive (IHC 3+: 19 and IHC 2+ with FISH positive: 12) early breast cancer who were enrolled in a phase II preoperative paclitaxel, gemcitabin and trastuzumab (PGH) combination chemotherapy trial were evaluated. The pre-chemotherapy tumor specimens were obtained from the breast mass (n=24) or metastatic lymph nodes (n=7). After completing 6 cycles of PGH therapy, all patients underwent breast conserving surgery or mastectomy. We applied trastuzumab and Quantum dot conjugated goat anti-human IgG (QD-IgG, 655nm, Invitrogen) in the process of immunuhistochemistry for HER2 using formalin-fixed paraffin embedded specimen. After antigen retrieval, trastuzuamb was applied followed by QD-IgG. The result of QHerceptest was scored as negative, weak positive, moderate positive, or strong positive, and its relative uptake (RU) were quantified by imaging analysis program (Q-IHC, http://www.bio-miblab.org).Results:The uptake of trastuzumab by QHerceptest was heterogenous, varying between 1.3% to 193.7%. Twenty one of 31 (67.7%) patients achieved pathologic complete response (pCR): 11 of 12 patients (91.7%) with QHerceptest strong positive tumors, 6 of 9 patients (66.7%) with QHerceptest moderate positive tumors, and 4 of 7 patients (57.1%) with QHerceptest weak positive tumors, and none of 3 patients (9.4%) with QHerceptest negative tumors (p=0.0203). Besides, RU was significantly different between non-pCR and pCR groups (43.9±38.3, 80.8±47.1, p=0.0396)Conclusion:We developed a new HER2 assay using trastuzumab and applied to clinical specimen. This assay showed heterogenous trastuzumab uptake in this patient population. Although the data need to be verified by further study, the assay could possibly eliminate patients among HER2 positive breast cancer who will not get benefit by trastuzumab .This study was supported by NCC Grant No 0710292-2 and NCC Grant No 0610240. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6050.