tbuckley/cabot-search huggingface dataset:
Review: Diabetes is not a coronary disease equivalent
Authors: Michael E. Farkouh
Journal: Annals of Internal Medicine (2009)

ACP Journal Club18 August 2009Review: Diabetes is not a coronary disease equivalentMichael E. Farkouh, MDMichael E. Farkouh, MDMount Sinai School of Medicine, New York, New York, USA (M.E.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-4-200908180-02006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationBulugahapitiya U, Siyambalapitiya S, Sithole J, Idris I. Is diabetes a coronary risk equivalent? Systematic review and meta-analysis. Diabet Med. 2009;26:142-8. https://pubmed.ncbi.nlm.nih.gov/19236616Clinical Impact RatingsCardiology: Endocrinology: References1 Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339:229-34. [PMID: 9673301] Google Scholar2 Malmberg K, Yusuf S, Gerstein HC, et al. Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry. Circulation. 2000;102:1014-9. [PMID: 10961966] Google Scholar3 American Diabetes Association. Consensus development conference on the diagnosis of coronary heart disease in people with diabetes: 10-11 February 1998, Miami, Florida. Diabetes Care. 1998;21:1551-9. [PMID: 9727908] Google Scholar4 Grundy SM, Howard B, Smith S Jr, et al. Prevention Conference VI: Diabetes and Cardiovascular Disease: executive summary: conference proceeding for healthcare professionals from a special writing group of the American Heart Association. Circulation. 2002;105:2231-9. [PMID: 11994261] Google Scholar5 Frye RL, August P, Brooks MM, et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med. 2009;360:2503-15. [PMID: 19502645] Google Scholar Author, Article, and Disclosure InformationAffiliations: Mount Sinai School of Medicine, New York, New York, USA (M.E.F.)This article was published at Annals.org on 4 August 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for CAD in asymptomatic patients with type 2 diabetes did not reduce risk for cardiac events Michael E. Farkouh Metrics 18 August 2009Volume 151, Issue 4Page: JC2-6KeywordsBlood pressureCohort studiesIschemiaMedical risk factorsMortalityMyocardial infarctionStable coronary artery diseaseStatinsSystematic reviewsType 2 diabetes ePublished: 18 August 2009 Issue Published: 18 August 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abnormalities of serum type III procollagen aminoterminal peptide in methotrexate-treated psoriatic patients with normal liver histology do not correlate with hepatic ultrastructural changes
Authors: P.K. OOGARAH, P.L. ROWLAND, D.M. MITCHELL, A. SMITH, R.J.G. CHALMERS, B. ROWAN, N.Y. HABOUBI
Journal: British Journal of Dermatology (1995)

In a previous study, it was shown that the serum levels of type III procollagen aminoterminal peptide (P3NP) were significantly greater in patients receiving methotrexate (MTX) treatment for psoriasis than in untreated control patients with psoriasis. Although levels were highest in patients with hepatic fibrosis and cirrhosis, serum P3NP concentrations in those patients with normal liver histology on light microscopy were also shown to be significantly higher than in controls. In the present study, liver biopsies from 22 such 'normal' patients were examined by electron microscopy, in order to determine whether P3NP levels correlated with ultrastructurally demonstrable fibrosis. Fibrosis in the perisinusoidal space of Disse was present in as many as 82% of biopsies. Although the prevalence of such fibrosis in psoriasis patients who have not received MTX is unknown, the high prevalence of Disse space fibrosis and of raised P3NP in MTX-treated patients suggests that MTX causes subtle liver damage in a majority of treated patients. However, we were unable to show a statistical correlation between P3NP and the degree of Disse space fibrosis.
QUANTITATIVE STUDIES ON THE PROPERDIN-COMPLEMENT SYSTEM
Authors: Myron A. Leon
Journal: The Journal of Experimental Medicine (1957)

The reaction of human, bovine, and pig properdin with excess zymosan exhibits an induction period followed by a rapidly accelerating formation of the properdin-zymosan (PZ) complex. Two methods for determining the quantity of PZ complex are given, one using human serum lacking properdin, the other using a fraction of pig serum containing complement components, C'1, C'3 and C'4.
Basics of Anesthesia
Authors: Martin H. Dauber
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroblastoma Killing Properties of Vδ2 and Vδ2-Negative γδT Cells Following Expansion by Artificial Antigen-Presenting Cells
Authors: Jonathan P.H. Fisher, Mengyong Yan, Jennifer Heuijerjans, Lisa Carter, Ayda Abolhassani, Jennifer Frosch, Rebecca Wallace, Barry Flutter, Anna Capsomidis, Mike Hubank, Nigel Klein, Robin Callard, Kenth Gustafsson, John Anderson
Journal: Clinical Cancer Research (2014)

The majority of circulating human γδT lymphocytes are of the Vγ9Vδ2 lineage, and have T-cell receptor (TCR) specificity for nonpeptide phosphoantigens. Previous attempts to stimulate and expand these cells have therefore focused on stimulation using ligands of the Vγ9Vδ2 receptor, whereas relatively little is known about variant blood γδT subsets and their potential role in cancer immunotherapy.
Viagra is licensed in Europe but rationed in Britain
Authors: A. Brooks
Journal: BMJ (1998)

The long awaited licence for sildenafil citrate (Viagra) was granted this week by the European Medicines Evaluation Agency, but British patients will not be able to get the drug on the NHS, at least for the time being.

Following the advice of the Standing Medical Advisory Committee, the Department of Health has advised doctors not to prescribe sildenafil until definitive guidance is drawn up in the next few weeks. This is the first time that the NHS has refused to fund a licensed drug with proved benefits to a large number of people. The efficacy and safety of sildenafil has already been demonstrated in trials and use in the United States.

Admitting that the decision was primarily because of cost, the health secretary, Frank Dobson, said: “Media coverage of this drug to date has created expectations that could prove a serious drain on the funds of the NHS. If this were to happen, other patients could be denied the treatment …
Death, Dying, and Organ Transplantation: Reconstructing Medical Ethics at the End of Life
Authors: Andrew R. Barnosky
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
No Kiss1ng by leptin during puberty?
Authors: Rexford S. Ahima
Journal: Journal of Clinical Investigation (2010)

Leptin exerts a permissive action on puberty by stimulating release of gonadotropin-releasing hormone (GnRH) in the hypothalamus. However, GnRH neurons lack leptin receptor (LepR), indicating that leptin must indirectly regulate these neurons. The Kiss1 gene produces kisspeptins that stimulate GnRH secretion. Because Kiss1 neurons express LepR and inactivation of Kiss1 causes hypogonadotropic hypogonadism, Donato et al., in this issue of the JCI, assessed whether deletion of LepR from Kiss1 neurons would prevent sexual maturation. Unexpectedly, mice lacking LepR in Kiss1 neurons had normal pubertal development and fertility. In contrast, deletion of LepR from the ventral premammillary nucleus, a region of the brain involved in sexual behavior, prevented puberty and fertility. These findings highlight the complex biology of leptin in reproduction.
Agreement in human interpretation of analog thallium myocardial perfusion images.
Authors: J E Atwood, D Jensen, V Froelicher, K Witztum, K Gerber, E Gilpin, W Ashburn
Journal: Circulation (1981)

To assess the agreement of human interpretation of analog thallium myocardial perfusion images, four experienced interpreters evaluated 100 images on two occasions using a form designed to limit reader variability. A high intraobserver agreement (agreement by same observer at separate times) of 89--93% was found when films were interpreted as normal or abnormal (a dichotomous decision). Interobserver agreement for a majority grouping of observers (three or four) was 75% for an abnormal and 68% for a normal interpretation. However, agreement ranged from 11--79% when interpreters were asked to read the anatomic location of defects. Posterior and lateral wall defects were interpreted with the least amount of agreement. These results indicate that caution must be taken when interpreting defect location. Using a scale of 1--10 to grade the severity of a defect, correlations of 0.82--0.86 were found when reading defects in the lateral and anterior projections. Higher correlations, from 0.86--0.94, were found in left anterior oblique views. Use of reporting forms with specific criteria, multiple observers at one occasion, and/or computer processing may improve agreement. A brief review of the agreement of cardiology testing procedures is also presented.
Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism
Authors: Chi V. Dang
Journal: Cancer Research (2010)

Abstract The MYC oncogene, which is frequently deregulated in human cancers, encodes a master transcription factor c-Myc (herein termed Myc) that integrates cell proliferation with metabolism through its regulation of thousands of genes including microRNAs (miRNA). In addition to its known function in regulating the cell cycle and glucose metabolism, recent studies document a role for Myc in stimulating glutamine catabolism, in part through the repression of miRNAs miR-23a and miR-23b. These observations suggest an additional level of complexity in tumor metabolism, which includes the commensal metabolic relationship between hypoxic and nonhypoxic regions of tumors as well as the surrounding stroma. Thus, a reevaluation of cancer metabolism considering glutamine catabolism with a better understanding of the tumor histological complexity is needed before cancer metabolism can be effectively targeted in therapy. Cancer Res; 70(3); 859–62
Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals
Authors: M. H. Shamji, V. Bellido, G. W. Scadding, J. A. Layhadi, D. K. M. Cheung, M. A. Calderon, A. Asare, Z. Gao, L. A. Turka, N. Tchao, A. Togias, D. Phippard, S. R. Durham
Journal: Allergy (2014)

Several studies have demonstrated the time course of inflammatory mediators in nasal fluids following nasal allergen challenge (NAC), whereas the effects of NAC on cells in the periphery are unknown. We examined the time course of effector cell markers (for basophils, dendritic cells and T cells) in peripheral blood after nasal grass pollen allergen challenge.Twelve participants with seasonal allergic rhinitis underwent a control (diluent) challenge followed by NAC after an interval of 14 days. Nasal symptoms and peak nasal inspiratory flow (PNIF) were recorded along with peripheral basophil, T-cell and dendritic cell responses (flow cytometry), T-cell proliferative responses (thymidine incorporation), and cytokine expression (FluoroSpot assay).Robust increases in nasal symptoms and decreases in PNIF were observed during the early (0-1 h) response and modest significant changes during the late (1-24 h) response. Sequential peaks in peripheral blood basophil activation markers were observed (CD107a at 3 h, CD63 at 6 h, and CD203c(bright) at 24 h). T effector/memory cells (CD4(+) CD25(lo) ) were increased at 6 h and accompanied by increases in CD80(+) and CD86(+) plasmacytoid dendritic cells (pDCs). Ex vivo grass antigen-driven T-cell proliferative responses and the frequency of IL-4(+) CD4(+) T cells were significantly increased at 6 h after NAC when compared to the control day.Basophil, T-cell, and dendritic cell activation increased the frequency of allergen-driven IL-4(+) CD4(+) T cells, and T-cell proliferative responses are detectable in the periphery after NAC. These data confirm systemic cellular activation following a local nasal provocation.
Erratum to “Regeneration of peripheral nerves by transplanted sphere of human mesenchymal stem cells derived from embryonic stem cells” [Biomaterials 33 (2012) 7039–7046]
Authors: Eun Ju Lee, Lianji Xu, Gi-Hwan Kim, Soo Kyoung Kang, Sae-Won Lee, Sung-Hye Park, Sukwha Kim, Tae Hyun Choi, Hyo-Soo Kim
Journal: Biomaterials (2012)
INTESTINAL PERISTALSIS.ACTION OF DIFFERENT AGENTS ON IT.
Authors: ISAAC OTT
Journal: JAMA (1905)

The recent method of Professor Magnus<sup>1</sup>of Heidelberg in the study by registration of the intestinal movements has simplified the investigation of the action of agents on the intestine. Magnus names two kinds of periodic movements of the intestine: 1, the pendulum movements, which follow each other rapidly in a contraction and relaxation of the intestine; and, 2, a tonus variation, much slower, but making periodic changes in the intestine. Drs. Kubliabko<sup>2</sup>and Alexandrowitsch, using the method of Magnus, have published a preliminary note on the action of several agents on the movements of the intestine. Our experiments were made by taking a piece of the small intestine, about 10 centimeters in length, of a rabbit or cat. This was placed vertically in a glass containing 225 c.c. of the modified Ringer solution as advised by Magnus. One end of the intestine was fastened by a hook to an L-shaped glass tube and the other by a thread to Porter's heart lever, slightly weighted.
Abstract 1340: Induction of necroptosis in ovarian cancer cells as a therapeutic strategy
Authors: Katelyn E. McCabe, Karl Bacos, Dan Lu, Joe R. Delaney, Mitchell Vamos, Nicholas D. P. Cosford, Dwayne G. Stupack
Journal: Cancer Research (2014)

Abstract The standard of care for ovarian cancer patients is carboplatin and paclitaxel. While many tumors initially respond to these drugs, patients often relapse with resistant disease. One of the mechanisms implicated in this development of resistance is evasion of apoptosis. Exploiting alternative death pathways, including necroptosis, is one strategy to treat such recurrent disease. Overexpressed in many cancers, inhibitor of apoptosis proteins (IAPs) represent one family of promising targets. Treatment of cells with an IAP antagonist can activate apoptosis or, if caspases are blocked, necroptosis. Among a panel of ovarian cancer cell lines screened for sensitivity to an IAP antagonist in combination with a pan-caspase inhibitor, only one (OVCAR3) was found to be sensitive, but this sensitivity was also exhibited by serous ovarian cancer cells isolated from patients. Combination treatment induces the formation of a p62-associated necrosome (RIPK1/RIPK3/FADD/caspase-8), and death can be rescued with inhibitors of RIPK1 and MLKL, two key proteins in the necroptosis pathway. All sensitive cell lines, but no resistant lines, express RIPK3 protein, and data from knockdown and ectopic expression studies demonstrate the dependency of cell death on kinase-active RIPK3, as well as caspase-8. Studies using a TNFα neutralizing antibody suggest that the combination elicits autocrine production of TNFα, which likely, in turn, activates the extrinsic death pathway in these cells. In conclusion, these findings illustrate that necroptosis can be induced in RIPK3-expressing ovarian cancer cells and indicate that in vivo studies are warranted. Citation Format: Katelyn E. McCabe, Karl Bacos, Dan Lu, Joe R. Delaney, Mitchell Vamos, Nicholas D. P. Cosford, Dwayne G. Stupack. Induction of necroptosis in ovarian cancer cells as a therapeutic strategy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1340. doi:10.1158/1538-7445.AM2014-1340
A Prospective Epidemiological Study of Psychosomatic and Psychiatric Syndromes in Young Adults
Authors: J. Binder, A. Dobler-Mikola, J. Angst
Journal: Psychotherapy and Psychosomatics (1982)

A prospective epidemiological field study of psychosomatic syndromes among 600 young adults in Zurich, Switzerland, is presented. During a period of 3 years, the respondents completed two questionnaires and were once personally interviewed about their psychosomatic and psychological syndromes in the 12 months prior to the inquiring dates. This communication concentrates on the results of the first questionnaire and the personal interview. The anamnestic data as well as the information about the frequency and duration of a number of psychosomatic syndromes serve to formulate a prognosis about the future course of these syndromes. This prognosis will then be compared with the results of the second follow-up consisting of the second questionnaire.
Balloon aortic valvuloplasty in adults: Failure of procedure to improve long-term survival
Authors: Eric B. Lieberman, Thomas M. Bashore, James B. Hermiller, John S. Wilson, Karen S. Pieper, Gordon P. Keeler, Cynthia H. Pierce, Katherine B. Kisslo, J. Kevin Harrison, Charles J. Davidson
Journal: Journal of the American College of Cardiology (1995)
An All-Purpose Valve for Cardiac Catheterization
Authors: David Littmann
Journal: New England Journal of Medicine (1962)

DURING cardiac catheterization patency of the system is customarily maintained by a continuous drip or by intermittent injections of dilute heparin solution. This is discontinued while pressures are recorded, when blood samples are drawn and during the injection of test substances. Whichever method is used, some type of switching mechanism is needed to make appropriate connections between catheter, heparin reservoir, transducer and syringe. This requires a number of valves or a valve gang with multiple levers that need separate positioning. Arrangements of this type almost inevitably lead to mistakes, sometimes in the most experienced hands. This is especially likely in . . .
CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL
Authors: Mascha Binder, Fabian Müller, Mareike Frick, Claudia Wehr, Frédéric Simon, Bernd Leistler, Hendrik Veelken, Roland Mertelsmann, Martin Trepel
Journal: Blood (2013)
Uncertainty in dying: keeping both hands open
Authors: E. M. Palmer
Journal: BMJ (2011)

Gott and colleagues explore clinicians’ views about transitions to palliative care in acute hospitals.1 Genuine uncertainty in recognising the point of transition emerges, alongside the inherent problem of “either-or” linear thinking about life, death, medicine, and the experience of being human.

The use of so called life prolonging treatments in acute settings does not preclude the use of …
Thyroid Hormone and Breast Cancer
Authors: Emilio C. Venezian
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The article by Mustacchi and Greenspan (237:1446-1447, 1977) reanalyzes the data of Kapdi and Wolfe (236:1124-1127, 1976) to reach the conclusion that "the retrospective study of Detroit women does not contain information indicating that premedication with thyroid hormone affected their risk of breast cancer either beneficially or adversely." That conclusion is not valid. It is true that Kapdi and Wolfe did not provide the strongest analysis of their data and that their formal statistical testing was done on tables in which confounding effects (such as age) were not excluded. It is also true that Mustacchi and Greenspan show that confounding could have affected those tests. On the other hand, Mustacchi and Greenspan performed tests of a composite null hypothesis (that breast cancer incidence is independent of age and thyroid therapy) and report only that "more than half of the contribution to the χ<sup>2</sup>value comes from
Secondary Lymphedema of the Leg: Its Characteristics and Diagnostic Implications
Authors: Richard D. Smith
Journal: JAMA (1963)

A study of 80 cases of secondary lymphedema was undertaken to determine whether there are any clinical characteristics of value in distinguishing it from idiopathic lymphedema and to determine the frequency of the various causes of secondary lymphedema. It was found that secondary lymphedema affects males and females with equal frequency, uncommonly begins before the age of 40 years, and seldom affects both legs unless it is caused by infection. Recurrent lymphangitis and cellulitis were found to be the commonest causes of secondary lymphedema; in such cases, the onset of swelling was always preceded by an infectious episode. The next most common cause was neoplastic disease, with prostatic carcinoma predominating in men and lymphoma in women; in several cases lymphedema was the first manifestation of the neoplasm.