Intravascular Coagulation in Fulminant Meningococcemia
Authors: WILLIAM G. MCGEHEE
Journal: Annals of Internal Medicine (1967)

Article1 August 1967Intravascular Coagulation in Fulminant MeningococcemiaWILLIAM G. MCGEHEE, M.D., SAMUEL I. RAPAPORT, M.D., F.A.C.P., PETER F. HJORT, M.D.WILLIAM G. MCGEHEE, M.D.Search for more papers by this author, SAMUEL I. RAPAPORT, M.D., F.A.C.P.Search for more papers by this author, PETER F. HJORT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-250 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute meningococcal infection in man pursues a variable course; usually the patient survives a severe illness characterized by a petechial skin eruption, meningitis, and a rapid response to appropriate antimicrobial therapy. However, an occasional unfortunate victim may die in profound and unresponsive shock hours after the onset of illness despite prompt and "adequate" treatment. Intravascular deposits of fibrin have been found at autopsy in such patients (1, 2), which suggests that diffuse intravascular coagulation could contribute to the clinical manifestations of meningococcal infection.Intravascular coagulation produces characteristic platelet and clotting factor changes. Therefore, we have measured platelet and clotting factor...References1. FERGUSONCHAPMAN JHOD: Fulminating meningococcic infections and the so-called Waterhouse-Friderichsen syndrome. Amer. J. Path. 24: 763, 1948. MedlineGoogle Scholar2. MARGARETTENMCADAMS WAJ: An appraisal of fulminant meningococcemia with reference to the Shwartzman phenomenon. Amer. J. Med. 25: 868, 1958. CrossrefMedlineGoogle Scholar3. BRECHERCRONKITE GEP: Morphology and enumeration of human blood platelets. J. Appl. Physiol. 3: 365, 1950. CrossrefMedlineGoogle Scholar4. WAREGUESTSEEGERS AGMMWH: Fibrinogen: with special reference to its preparation and certain properties of the product. Arch. Biochem. 13: 231, 1947. 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Author, Article, and Disclosure InformationAffiliations: Los Angeles, CaliforniaFrom the Department of Medicine, University of Southern California School of Medicine, and the Department of Medicine and the Communicable Disease Service, Los Angeles County General Hospital, Los Angeles, Calif.This study was supported by grants HE 06128-06 and TI AM 5192-08, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to William G. McGehee, M.D., University of Southern California School of Medicine, 2025 Zonal Ave., Los Angeles, Calif. 90033. 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EDWARD MACMAHON, M.D., LOUIS WEINSTEIN, PH.D., M.D., F.A.C.P.Management of Bacterial Meningitis in Children 1 August 1967Volume 67, Issue 2Page: 250-260KeywordsAntimicrobialsAutopsyFibrinHospital medicineMedical servicesMeningitisMeningococcal diseaseMeningococcemiaPlateletsShock Issue Published: 1 August 1967 PDF downloadLoading ...