tbuckley/cabot-search huggingface dataset:
Cardiovascular Diseases and Risk of Hip Fracture
Authors: Ulf Sennerby
Journal: JAMA (2009)

ContextRecent studies indicate common etiologies for cardiovascular disease (CVD) and osteoporotic fractures.Objectives To examine the relation between CVD and risk of hip fracture in twins and evaluate the relative importance of genetics and lifestyle factors in this association. Design, Setting, and ParticipantsA cohort of all 31 936 Swedish twins born from 1914-1944 was followed up from the age of 50 years.The National Patient Registry identified twins with CVDs and fractures from 1964 through 2005.Time-dependent exposures using Cox proportional hazard regression models were evaluated.Main Outcome Measure Time to hip fracture after diagnosis of CVD. ResultsThe crude absolute rate of hip fractures was 12.6 per 1000 person-years after a diagnosis of heart failure, 12.6 per 1000 person-years after a stroke, 6.6 per 1000 personyears after a diagnosis of peripheral atherosclerosis, and 5.2 per 1000 person-years after a diagnosis of ischemic heart disease compared with 1.2 per 1000 person-years for those without a CVD diagnosis.The multivariable-adjusted hazard ratio (HR) of hip fracture after a diagnosis of heart failure was 4.40 (95% confidence interval [CI], 3.43-5.63);after a stroke, the HR was 5.09 (95% CI, 4.18-6.20);after a diagnosis of peripheral atherosclerosis, the HR was 3.20 (95% CI, 2.28-4.50);and after an ischemic heart disease event, the HR was 2.32 (95% CI, 1.91-2.84).Identical twins without heart failure and stroke also had, after their co-twins had been exposed to these respective diseases, an increased rate of hip fracture.These sibling twins pseudoexposed for heart failure had a multivariable-adjusted HR of 3.74 (95% CI, 1.97-7.10)for hip fracture, whereas pseudoexposure for stroke had an HR of 2.29 (95% CI, 1.20-4.35).Conclusions A diagnosis of CVD was significantly associated with risk of subsequent hip fracture.Increased risks in co-twins without an index diagnosis suggest genetic factors in the association between CVD and osteoporotic fractures.
Process Measures, Outcome Measures, and Heart Failure
Authors: Jerod M. Loeb
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leo Lamphere Strikes Again
Authors: Bernard A. Heckman
Journal: JAMA (1963)

To the Editor:—  Leo Lamphere, so well described by Dr. John S. Chapman in an earlier issue ofThe Journal(165:927 [Oct 26] 1957), appeared at the emergency room of The New York Hospital-Cornell Medical Center on May 16, 1963. He alleged that he had been working as a carpenter in White Falls, N.Y., when a large piece of lumber fell on his legs. The legs had become swollen, and after appearing at a private physician's office complaining of pleuritic pain in the right side of his chest, he had been admitted to a small hospital upstate. Because of dissatisfaction with the facilities of that hospital, he had signed out after 30 min and traveled by bus to New York City.  When seen by the admitting officer, he first insisted that he be allowed to use the bathroom. When he returned, he promptly coughed up 30 cc of bright
Hepatoid adenocarcinoma of the stomach: an unusual case of elevated alpha-fetoprotein with prior treatment for hepatocellular carcinoma
Authors: Joon Seong Ahn, Ja Ryong Jeon, Hong Seok Yoo, Taek Kyu Park, Cheol Keun Park, Dong Hyun Sinn, Seung Woon Paik
Journal: Clinical and Molecular Hepatology (2013)

Hepatoid adenocarcinoma (HAC) is a rare type of extrahepatic carcinoma whose morphology is similar to that of hepatocellular carcinoma (HCC). Metachronous HCC and HAC in the same patient is extremely rare. The case of a 68-year-old man with chronic hepatitis B infection who had both HCC and HAC of the stomach is reported herein. Nine years previously this patient had been diagnosed with HCC and received a right lobectomy. HCC that recurred at the caudate lobe at 6 months after the operation was successfully treated with transarterial chemoembolization. The patient was followed up regularly thereafter without evidence of tumor recurrence for 9 years. In July 2010 his serum alpha-fetoprotein (AFP) level elevated from 6.5 ng/mL to 625.4 ng/mL, and he developed a probable single metastatic lymph node around the hepatic artery without intrahepatic lesions. Subsequent evaluation with upper endoscopy revealed a 4-cm ulcerative lesion on the antrum of the stomach. Subtotal gastrectomy was performed with lymph-node dissection. Histologic examination revealed a special type of extrahepatic AFP-producing adenocarcinoma-HAC with lymph-node metastasis-which indicates that HAC can be a cause of elevated AFP even in patients with HCC. HAC should be considered if a patient with stable HCC exhibits unusual elevation of AFP.
Unrecognized Adult Phenylketonuria
Authors: Thomas L. Perry, Shirley Hansen, Bluma Tischler, Frances M. Richards, Marlene Sokol
Journal: New England Journal of Medicine (1973)

Phenylketonuria is rarely suspected in adults of normal intelligence, and its complications can therefore be overlooked. Of four adult siblings with previously unrecognized and untreated phenylketonuria, three have normal intelligence, one being a university graduate. Three phenylketonuric women in the sibship have given birth to nine non-phenylketonuric children, all of whom have varying degrees of intellectual deficit. Two of the adults with phenylketonuria have suffered major psychotic illnesses resulting in their admission to a mental hospital, where they were inappropriately given electroconvulsive therapy and antipsychotic drugs. Our experience, together with that of others, suggests that routine testing of urine with the ferric chloride test early in every woman's first pregnancy could prevent some cases of mental retardation. Similar routine screening of the urine of mentally ill patients might avoid illogical treatment for occasional psychotic adults. (N Engl J Med 289:395–398, 1973)
Unhappy doctors: what are the causes and what can be done?
Authors: Nigel Edwards, Mary Jane Kornacki, Jack Silversin
Journal: BMJ (2002)

<h3>Abstract</h3> Fluorescent proteins are essential reporters in cell biology and molecular biology. Here, we reveal that red-fluorescent proteins possess an alternative translation initiation site that produces a short functional protein isoform. The short isoform creates significant background fluorescence that biases the outcome of expression studies. Our investigation identifies the short protein isoform, traces its origin, and determines the extent of the issue within the family of red fluorescent protein. Our analysis shows that the short isoform defect of the red fluorescent protein family may affect the interpretation of many published studies. Finally, we provide a re-engineered mCherry variant that lacks background expression as an improved tool for imaging and protein expression studies.
Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity
Authors: Chunyan Gu, Gretchen H. Stein, Ning Pan, Sandra Goebbels, Hanna Hörnberg, Klaus-Armin Nave, Pedro Herrera, Peter White, Klaus H. Kaestner, Lori Sussel, Jacqueline E. Lee
Journal: Cell Metabolism (2010)
Prolactin and Sexual Function
Authors: Kenneth L. Cohen
Journal: JAMA (1981)

To the Editor.—  The letter by Ambrosi et al (1980;244:2608) emphasizes the role of hyperprolactinemia in sexual disturbances in men. We became interested in this association because of the frequent occurrence of impotence in hypertensive patients receiving methyldopa therapy. 1 Since methyldopa can raise the serum prolactin level, 2 we investigated the possibility that this is the mechanism through which this drug interferes with sexual function.  Twelve patients in the hypertension clinic taking only a thiazide diuretic and methyldopa for blood pressure control agreed to participate in a study that included a simple questionnaire regarding the occurrence and degree of potency problems, a personal interview, and the obtaining of a morning serum prolactin sample. Patients with diabetes, peripheral vascular disease, long-term alcohol abuse, and previous psychiatric illness were excluded, as were those taking other drugs known to be associated with impotence. Prolactin level was determined by radioimmunoassay, with normal values
Lentiviral Vector–mediated Autonomous Differentiation of Mouse Bone Marrow Cells into Immunologically Potent Dendritic Cell Vaccines
Authors: Richard C Koya, Takahiro Kimura, Antoni Ribas, Nora Rozengurt, Gregory W Lawson, Emmanuelle Faure-Kumar, He-jing Wang, Harvey Herschman, Noriyuki Kasahara, Renata Stripecke
Journal: Molecular Therapy (2007)

Approaches facilitating generation of dendritic cell (DC) vaccines for clinical trials and enhancing their viability, bio-distribution, and capacity to stimulate antigen-specific immune responses are critical for immunotherapy. We programmed mouse bone marrow (BM) cells with lentiviral vectors (LV-GI4) so that they produced granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) in an autonomous manner. DC/LV-GI4 cells underwent autonomous trans-differentiation to yield typical phenotypic characteristics of DCs. DC/LV-GI4 cells that self-differentiated either ex vivo or in vivo showed persistent and robust viability and stimulated high influx of DCs into draining lymph nodes (LNs). The immunostimulatory efficacy of DC/LV-GI4 cells was evaluated using MART1 and TRP2 as co-expressed melanoma antigens. Mice vaccinated with DC/LV-GI4 cells that self-differentiated in vitro or in vivo produced potent antigen-specific responses against melanoma, which correlated with protective and long-term therapeutic anti-tumor effects. Thus, DC precursors can be genetically engineered after a single ex vivo manipulation, resulting in DC vaccines with improved activity.
Being strategic about smoking
Authors: J. Chambers
Journal: BMJ (1999)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Being strategic about smoking Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Planning, control, and the illusion of explanation
Authors: David A. Westwood
Journal: Behavioral and Brain Sciences (2004)

Several aspects of Glover's planning–control model (PCM) appear incompatible with existing data. Moreover, there is no logical reason to suppose that separate visual representations should be required for the “planning” and “control” of actions in the first place. Although intuitively appealing, the PCM appears to lack strong empirical support.
COMMUNITY PRESSURES AND A STATE HOSPITAL PROGRAM FOR CHILDREN
Authors: JOSEPH J. REIDY
Journal: American Journal of Psychiatry (1960)

I have tried to show how a public hospital can give the high quality of care given by private residential centers. Except for our plan of having the child live with his family each weekend, there are no new concepts of care but rather an application of those principles of modern psychiatric care which are well known and which have been practiced for years by well known hospitals and social agencies. There must be a determination to resist pressure from many sources and a willingness to work with community agencies. If such a program can surmount the initial difficulties it can demonstrate by its treatment results the effectiveness of its work.
Atherosclerotic Vascular Disease
Authors: Robert L. Grissom
Journal: JAMA (1968)

This volume is a collection of 51 papers presented at the 16th Hahnemann Symposium in April 1966. All authors were either from the United States or Canada, with about a fifth from Hahnemann Medical College. There are seven parts, considering in sequence the atherosclerotic plaque, factors contributing to atherogenesis, hyperlipidemia, coronary heart disease, renovascular hypertension, extracranial cerebrovascular insufficiency, and peripheral vascular insufficiency. The five papers on surgery deal in the main with selection of patients and the results of operations. A generous list of bibliographic references accompanies each article. Illustrations and tables are plentiful and generally clear. There are no color plates. Most of the authors are well known in the field of atherosclerosis so the reader interested in examining current opinions in the field will likely find a quick answer here. Articles are presented without editorial comment or discussion. None of the subjects is treated exhaustively, of course. Obviously,
Protective and heart-crossreactive epitopes located within the NH2 terminus of type 19 streptococcal M protein.
Authors: M S Bronze, E H Beachey, J B Dale
Journal: The Journal of Experimental Medicine (1988)

M protein was purified to homogeneity from limited pepsin digests of intact type 19 streptococci (pep M19). The purified pep M19 when emulsified in CFA and injected into rabbits evoked type-specific and crossreactive opsonic antibodies, as well as heart-crossreactive antibodies. The NH2-terminal primary structure of pep M19 was determined and a peptide copying the first 24 amino acids [SM19(1-24)C] was chemically synthesized. Rabbits that were immunized with the unconjugated peptide developed antibodies that recognized the native pep M19, as determined by ELISA, and opsonic antibodies against type 19 streptococci, as determined by in vitro opsonophagocytosis tests. The synthetic peptide also evoked antibodies that crossreacted with a 60-kD sarcolemmal membrane protein of human myocardium. By using overlapping synthetic subpeptides as immunoinhibitors, the opsonic and heart-crossreactive epitopes of SM19(1-24)C were localized to SM19(11-24)C. Our data confirm the presence of heart-crossreactive epitopes within the primary structure of pep M19 and show that these potentially harmful autoimmune epitopes may be located in the NH2-terminal regions of certain M proteins. We conclude that continued efforts to identify the primary structures of protective and heart-crossreactive epitopes will be necessary to elucidate the pathogenesis of acute rheumatic heart disease and to develop safe and effective streptococcal vaccines.
Specific Immunodiagnosis of Hepatocellular Carcinoma by Leucocyte Adherence Inhibition
Authors: W. J. Halliday, J. W. Halliday, C. B. Campbell, A. E. Maluish, L. W. Powell
Journal: BMJ (1974)

The leucocyte adherence inhibition test provides a rapid, reliable, and specific technique for the immunodiagnosis of primary hepatocellular carcinoma (malignant hepatoma). The patient9s blood leucocytes are tested in vitro for cell-mediated immunity against tumour-associated antigens and the serum is tested for blocking factor which interferes with the immunological reaction. Specific reactivity of both leucocytes and serum was consistently detected in patients with malignant hepatoma, and negative reactions were obtained in other liver diseases including secondary tumours of the liver. The test has provided positive evidence for the presence of hepatoma when more conventional methods gave doubtful or negative results. A positive result preceded the clinical appearance of tumour by up to three years in two patients.
False-Positive Radioiodine Whole-Body Scan in Thyroid Cancer Patients Due to Unrelated Pathology
Authors: SIEMA M. BAKHEET, MUHAMMAD M. HAMMAMI
Journal: Clinical Nuclear Medicine (1994)

Radioiodine whole-body scanning is the imaging modality of the highest accuracy in diagnosing metastases from differentiated thyroid cancer. However, unrelated pathology in one of several nonthyroidal tissues that normally take-up/secrete radioiodine may result in a false positive scan. The authors report cases of an ectopic kidney, chronic sinusitis, dacryocystitis, and an artificial eye, complicating differentiated thyroid cancer, that on radioiodine scanning mimicked lumbar, frontal, and left and right orbital bone metastases, respectively. The nature of the radioiodine uptake was suspected from the results of a bone scan and proven by ultrasound (ectopic kidney), by reimaging after specific treatment (chronic sinusitis, and dacryocystitis), or by postwashing reimaging (artificial eye). To our knowledge, this is the first report of such cases. Nonthyroidal pathology should be excluded before exposing patients with apparent thyroid cancer metastases that have atypical characteristics on radioiodine whole body imaging.
The Effect of Intravenous Injection of Emulsified Vitamin K, on the Hypoprothrombinemia Induced by Tromexan
Authors: William C. Van Buskirk, John S. Belko, Thomas J. Giovanniello
Journal: New England Journal of Medicine (1953)

TROMEXAN (ethyl biscoumacetate; 3, 3′ carboxymethylenebis- [4-hydroxycoumarin] ethyl ester also known as B.O.E.A., D.E.A. and Pelentan) has been proved to be an effective agent for inducing hypoprothrombinemia. After synthesis of the drug in 1948 by Reinis and Kubik,1 many investigators reported favorable clinical results. Severe hemorrhages, however, have followed its use.2 3 4 Since Vitamin K1 has been shown to be of value in reversing the hypoprothrombinemia induced by Dicumarol,5 it seemed possible that it would prevent catastrophes resulting from Tromexan therapy. The purpose of the present paper is to report observations on this point.Materials and MethodsFor the purpose of . . .
Chemical Diagnosis of Disease
Authors: Rex B. Conn
Journal: JAMA (1980)

This encyclopedic volume is a collection of minimonographs on the biochemistry of disease and the use of chemical tests in medical diagnosis. The editors are well known for their contributions to clinical chemistry and chemical pathology. The 38 contributors are a distinguished group of physicians and laboratory scientists, most of whom are from Great Britain. The objective of this monumental editorial effort was to provide a comprehensive source of information on the interpretation of laboratory tests in clinical chemistry. Diagnostic tests can be discussed from any one of several perspectives: the method of analysis, the entity measured, the organ or organ system involved, or the disease process being considered. Integration of information derived from these different perspectives and formulation of a logical presentation is not a simple task. The editors have purposely omitted discussion of methodology except where it is essential to interpretation of results, and chapters are organized either
THE SURGERY OF THE PERIPHERAL NERVE INJURIES OF WARFARE
Authors: H. Platt
Journal: BMJ (1921)

I_~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~_R"6lom -The varying degree of virulence of the attackingorganism is of supreme importance.The great majority of cases of tuberculosis are fortunately of low virulence, and, given suitable conditions, are favourable for treatment; but in some cases the virulence is so higlh as to destroy tlle person in a few weeks or months, and these are the cases popularly known-as-galloping consumption.From my own observation I am inclined to tllink that in this country the virulence of the tubercle bacillus is less than it was thirty years ago.The number of dleatlhs in England and WVales from tuberculosis in 1920 was 12,000 less than in 1919, a most gratifying record of progress in dealing with this terrible disease, which destroys 60,000 lives each year in England alone.A large percentage of the population receive at some period of their lives a mild infection of tubercle which, in many cases, produces no definite symptoms.These persons recover, and are to some extent immunized against a further and more severe infection.If we can induce some immunity by artificial means in children wlhose parents or relatives are tuberculous, and
Possible Drug Interaction between Itraconazole and Vinorelbine Tartrate Leading to Death after One Dose of Chemotherapy
Authors: Elena Bosque
Journal: Annals of Internal Medicine (2001)

Letters6 March 2001Possible Drug Interaction between Itraconazole and Vinorelbine Tartrate Leading to Death after One Dose of ChemotherapyElena Bosque, PhDElena Bosque, PhDPacifica, CA 94044 (Bosque)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-5-200103060-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A drug interaction may have led to the death of my father. An active 72-year-old man, he presented with fungal pneumonia in November 1996; localized lung adenocarcinoma was diagnosed. (At autopsy, one peribronchial and two lung lymph nodes were involved.) He received itraconazole (Sporanox, Janssen Pharmaceutica, Titusville, New Jersey) in January 1997. In the same month, he received vinorelbine tartrate (Navelbine, Glaxo Wellcome, Inc., Research Triangle Park, North Carolina) and cisplatin.Three days after chemotherapy, he experienced constipation and painful oral mucositis, which were treated with laxatives and analgesia, respectively. Five days after chemotherapy, he began to ... Author, Article, and Disclosure InformationAffiliations: Pacifica, CA 94044 (Bosque) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byItraconazoleVinca alkaloidsDrug InteractionsPrediction of pharmacokinetic drug–drug interaction caused by changes in cytochrome P450 activity using in vivo informationDRUGS USED IN CANCER CHEMOTHERAPYANTIFUNGAL DRUGSEvaluation of Potential Interaction Between Vinorelbine and ClarithromycinMolecular Pharmacokinetics of Catharanthus (Vinca) AlkaloidsAntiemetic therapy in older cancer patientsItraconazoleVinca alkaloidsFrequency of potential azole drug-drug interactions and consequences of potential fluconazole drug interactionsCytostatic drugsDrug InteractionsA guide to clinically relevant drug interactions in oncologyAntifungal drugsCurrent Awareness 6 March 2001Volume 134, Issue 5Page: 427KeywordsAlkaloidsChemotherapyDrug interactionsDrug therapyEnzymesIntubationLungsLymph nodesPneumoniaResuscitation ePublished: 6 March 2001 Issue Published: 6 March 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development
Authors: Robin Kageyama, Jennifer L. Cannons, Fang Zhao, Isharat Yusuf, Christopher Lao, Michela Locci, Pamela L. Schwartzberg, Shane Crotty
Journal: Immunity (2012)