tbuckley/cabot-search huggingface dataset:
Neutrophilic Reduction of NBT Dye: Acquired Defect
Authors: Burton R. Andersen, Wuthisak Soonattrakul
Journal: Annals of Internal Medicine (1973)

Letters, Comments, and Corrections1 February 1973Neutrophilic Reduction of NBT Dye: Acquired DefectBURTON R. ANDERSEN, M.D., WUTHISAK SOONATTRAKUL, M.D.BURTON R. ANDERSEN, M.D.Search for more papers by this author, WUTHISAK SOONATTRAKUL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-2-301_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Matula and Paterson (1) have reported that all of their patients with untreated bacteremia had positive nitroblue tetrazolium (NBT) tests. We have seen a patient with bacteremia, probably due to endocarditis, who had an unusual response of her neutrophils to the NBT dye.A 65-year-old woman with adult-onset diabetes was admitted to the hospital because of cough and left-chest pain of 3 months' duration. She was pale and weak but afebrile. She had slight cardiomegaly, signs of early congestive heart failure, and a loud pansystolic murmur at the apex that had been present for many years. A...REFERENCE1. MATULAPATERSON GP: Spontaneous in vitro reduction of nitroblue tetrazolium by neutrophils of adult patients with bacterial infections. N Engl J Med 285:311-316, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BURTON R. ANDERSEN, M.D.; WUTHISAK SOONATTRAKUL, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLeukocyte function in children with malignanciesAn appraisal of the nitroblue tetrazolium reduction testThe nitroblue tetrazolium (NBT) dye test in determining fever source in lymphomaPositive NBT test associated with Henoch-Schönlein purpura (HSP)Plasma Factor Affecting the NBT Reducing Capacity of Neutrophils 1 February 1973Volume 78, Issue 2Page: 301-302KeywordsBacteremiaEndocarditisHeart failureNeutrophilsType 2 diabetes ePublished: 1 December 2008 Issue Published: 1 February 1973 PDF downloadLoading ...
A Psychiatrist's Experiences in General Practice in a Hospital Emergency Room
Authors: Samuel A. Nigro
Journal: JAMA (1970)

A psychiatrist returning to part-time general practice in a suburban general hospital emergency room managed 469 patients in five months. Patients were assigned one of nine categories as indicators of the degree of psychological attention needed. More than half of the sample had "pure" medical-surgical problems. More than one fourth had problems primarily of psychological origin. Less than 12% were physically sick enough for admission; psychiatric help was recommended for 8%. All patients, directly or indirectly via relatives, required attention in a psychologically sound manner. The frequency of psychological problems indicates that medical facilities are in a psychosocial epidemic. The psychiatrist felt his perception of and way of dealing with patients was markedly affected by his specialty training in comparison to his prepsychiatry practice.
Synergistic Production of Lung Free Radicals by Diesel Exhaust Particles and Endotoxin
Authors: Toyoko Arimoto, Maria B. Kadiiska, Keizo Sato, Jean Corbett, Ronald P. Mason
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

The present study tested the hypothesis that free radicals were involved in the pathogenesis of lung injury caused by diesel exhaust particles (DEP) and bacterial lipopolysaccharides (LPS). Intratracheal coinstillation of DEP and LPS in rat lungs resulted in synergistic enhancement of free radical generation in the lungs. The radical metabolites were characterized as lipid-derived by electron spin resonance (ESR). The free radical generation was paralleled by a synergistic increase in total protein and by infiltration of neutrophils in the bronchoalveolar lavage (BAL) fluid of the lungs. Experiments with NADP-reduced (NADPH) oxidase and iNOS knockout mice showed that NADPH oxidase and iNOS did not contribute to free radical generation. However, pretreatment with the macrophage toxicant GdCl(3), the xanthine oxidase (XO) inhibitor allopurinol, and the Fe(III) chelator Desferal resulted in a marked decrease in free radical generation, lung inflammation, and lung injury. These effects were concomitant with the inhibition of XO activity in BAL, suggesting that the activated macrophages and the activity of XO contributed to the generation of free radicals caused by DEP and LPS. This is the first demonstration that DEP and LPS work synergistically to enhance free radical generation in lungs, mediated by the activation of local XO.
Changing Frequency of Arteriosclerosis in Mammals and Birds at the Philadelphia Zoological Garden
Authors: H. L. RATCLIFFE, M. T.I. CRONIN
Journal: Circulation (1958)

From 1901 through 1932 arteriosclerosis was found in less than 3 per cent of autopsies on mammals and birds at the Philadelphia Zoological Garden, but thereafter its frequency has increased to about 20 per cent. This study has attempted to identify factors that may be associated with this change in frequency.
Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes
Authors: Ryan M. Taylor, Timothy Davern, Santiago Munoz, Stephen-Huy Han, Brendan McGuire, Anne M. Larson, Linda Hynan, William M. Lee, Robert J. Fontana
Journal: Hepatology (2006)

Acute liver failure (ALF) due to hepatitis A virus (HAV) infection is an uncommon but potentially lethal illness. The aim of this study was to identify readily available laboratory and clinical features associated with a poor prognosis among ALF patients with HAV infection. The presenting features of 29 adults with anti-HAV IgM positive ALF enrolled in the ALFSG_between 1998 and 2005 were reviewed. The HAV patients listed for transplantation by UNOS were also reviewed. Acute HAV accounted for 3.1% of patients enrolled in the ALFSG. At 3 weeks follow-up, 16 had spontaneously recovered (55%), 9 underwent transplantation (31%), and 4 had died (14%). A prognostic model incorporating 4 presenting features (serum ALT &lt;2,600 IU/L, creatinine &gt;2.0 mg/dL, intubation, pressors) had an AUROC for transplant/death of 0.899 which was significantly better than the King's College criteria (0.623, P = .018) and MELD scores (0.707, P = .0503). Between 1988 and 2005, the frequency of patients requiring liver transplantation for HAV in the UNOS database significantly decreased from 0.7 % to 0.1% ( P &lt; .001). In addition, the proportion of HAV cases enrolled in the ALFSG significantly decreased from 5% to 0.8% ( P = .007). In conclusion , the frequency of HAV patients enrolling in the ALFSG and being listed for liver transplantation in the United States has declined in parallel. A prognostic index consisting of 4 clinical and laboratory features predicted the likelihood of transplant/death significantly better than other published models suggesting that disease specific prognostic models may be of value in non-acetaminophen ALF.
Steroids in Sports: After Four Decades, Time to Return These Genies to Bottle?
Authors: Virginia Cowart
Journal: JAMA (1987)

IN THE AFTERMATH of the first postseason drug testing by the National Collegiate Athletic Association (NCAA), two things are apparent. Many college football players see nothing wrong with taking anabolic steroids, either from a health or ethical stand-point, and, evidently, little is known about these drugs' effects. The most publicized of the more than 20 collegiate athletes from at least seven universities who were barred from participation in postseason bowl games because they had used steroids was All-America linebacker Brian Bosworth of the University of Oklahoma. At a press conference, Bosworth criticized the NCAA and said: "Steroids are a legal drug. I'll continue to fight against the abuse of drugs—recreational drugs that are destroying society. Steroids aren't destroying society." Several of the athletes whose steroid use was detected said they took them for injuries, primarily knee injuries. These statements seemed to indicate that not only were they eager to make
Persistence of subendocardial perfusion after subtotal coronary embolisation
Authors: G. PELOSI, A. L'ABBATE, M. G. TRIVELLA, M. D. VACCHE, D. LEVANTESI, L. TADDEI, M. MARZILLI
Journal: Cardiovascular Research (1988)

The effects of acute subtotal embolisation of small coronary arteries on regional coronary flow and vasodilator reserve were investigated in seven open chest dogs. Unlabelled plastic microspheres (26(2) μm in diameter) were injected as boluses of 200 000-400 000 microspheres into the circumflex artery. Embolisation was repeated until reactive hyperaemia was totally abolished, which occurred after the injection of 62 000(4000) microspheres per gram. Intracoronary adenosine was then infused for 20 min at 1.2 mg·min−1. Regional myocardial blood flow was measured by radioactive microspheres under control conditions, after coronary embolisation, and during adenosine infusion. Coronary blood flow (0.98(0.07) ml·min−1·g−1) was reduced to 0.66(0.08) ml·min−1·g−1 after embolisation (p<0.005) when reactive hyperaemia was practically abolished. Embolisation reduced epicardial flow from 0.93(0.08) to 0.40(0.09) ml·min−1·g−1 (p <0.001), whereas endocardial flow was unchanged (1.03(0.11) vs 0.92(0.14) ml·min−1·g−1; NS); as a consequence, the endocardial to epicardial flow ratio increased from the control value of 1.11 (0.06) to 2.31(0.35) (p<0.005). Adenosine infusion increased coronary blood flow from 0.66(0.08) to 1.66(0.41) ml·min−1·g−1 (p <0.05). Endocardial blood flow increased more than epicardial blood flow, leading to a further increase in the endocardial to epicardial flow ratio (3.79(0.13); p<0.05). Thus it is concluded that (a) embolisation of small arteries abolishes the reactive hyperaemic response to transient coronary occlusion; (b) microembolisation predominantly reduces subepicardial perfusion; and (c) adenosine administration may increase total and regional flow after subtotal occlusion of coronary small arteries.
Schizophrenic-Like Reactions and Affective Psychoses Associated with Temporal Lobe Epilepsy: Etiological Factors
Authors: P. FLOR-HENRY
Journal: American Journal of Psychiatry (1969)

A controlled comparative investigation showed that temporal lobe epilepsy of the dominant hemisphere predisposes to psychotic manifestations; epilepsy of the non-dominant temporal lobe is associated with manic-depressive psychotic reactions and epilepsy of the dominant temporal lobe with schizophrenic-like psychotic reactions. Also, the presence of psychomotor seizures and frequent temporal seizures is inversely correlated with psychosis; and in epileptic psychoses, periodicity is correlated with minimal brain damage and chronicity with maximal brain damage.
Cimetidine, Ranitidine, and Epstein-Barr Virus Infection
Authors: JAY A. GOLDSTEIN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 July 1986Cimetidine, Ranitidine, and Epstein-Barr Virus InfectionJAY A. GOLDSTEIN, M.D.JAY A. GOLDSTEIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-139_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Patients with chronic Epstein-Barr virus infection (1) might be relieved to have their syndrome diagnosed but are usually discouraged when told there is no recognized effective therapy, because their symptoms are often disabling. I have treated ten such patients, who had dysfunction from 9 months to 15 years. All had antibody to Epstein-Barr early antigen in titers of 1:40 or greater. Because of my success in treating acute mononucleosis with cimetidine (2), I decided to try cimetidine or ranitidine on these patients.In the usual doses prescribed for treatment of peptic ulcer disease, every one of these...References1. JONESRAYMINNICHHICKSKIBLERLUCAS JCLMRD. Evidence for active Epstein-Barr virus infection in patients with persistent unexplained illnesses: elevated anti-early antigen antibodies. Ann Intern Med. 1985;102:1-8. LinkGoogle Scholar2. GOLDSTEIN J. Cimetidine and mononucleosis [Letter]. Ann Intern Med. 1983;99:410-1. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAY A. GOLDSTEIN, M.D.Affiliations: 500 South Anaheim Hills Road; Anaheim Hills, CA 92807 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRETRACTED: Clinical and Scientific Rationale for the "MATH+" Hospital Treatment Protocol for COVID-19Famotidine Against SARS-CoV2: A Hope or Hype?COVID-19: History of Disease Avoidance, Social Spacing and Work/Home MatrixEpstein-Barr virus (EBV) reactivation and therapeutic inhibitorsCurrent Advances in CFS TherapyH2-Antagonists and the Common ColdA. SICORE, M.D. 1 July 1986Volume 105, Issue 1Page: 139-139KeywordsAntigensEpstein-Barr virusPeptic ulcers ePublished: 1 December 2008 Issue Published: 1 July 1986 PDF downloadLoading ...
New EU health chief questions plan to let drug industry communicate directly with patients
Authors: R. Watson
Journal: BMJ (2010)

John Dalli, a former Maltese economy and social affairs minister, will have more influence over public health policy than any of his predecessors when he takes up his post as the European Union’s health commissioner next month.

In a move that underlines the increasing importance of health issues on the European agenda, his five year mandate, which is due to start on 1 February, will include responsibility for drafting all future pharmaceutical legislation. The previous health commissioners, Markos Kyraniou and Androulla Vassiliou, had argued unsuccessfully for this policy area to be transferred from the European Commission’s enterprise and industry directorate general, where primary importance is given to commercial considerations, to their own bailiwick.

Now the commission’s president, Jose Manuel Barroso, has agreed to the transfer. A deciding factor was the Lisbon Treaty, which came into force at the beginning of December and updates the European Union’s rulebook. It includes pharmaceuticals and medical devices under the health policy heading.

The transfer has been generally welcomed. The European consumer organisation BEUC says that it “will bring more consistency and coherence …
Carcinoma of the larynx.
Authors: D. F. Harrison
Journal: BMJ (1969)

The larynx is in many ways a unique structure, combining the primitive functions of respiration and deglutition with the phylogenetically more recent acquisition of speech.Impairment of the voice has long been recognized as an early symptom of laryngeal cancer, yet the management of neoplasms of this organ presents special problems to the laryngologist, since satisfactory rehabilitation after treatment requires, wherever possible, an adequate means of communication.The psychological importance of the voice varies with different ethnic groups, but on no occasion must its preservation be allowed to jeopardize effective eradication of disease, a policy which unfortunately is not universally practised. Incidence and Possible Aetiological FactorsIt is estimated that laryngeal cancer represents less than 2% of all human neoplasms and is therefore relatively uncommon.Considerable difficulties may be experienced when attempting comparisons of incidence rates originating from various parts of the world, for in some countries deaths from laryngeal cancer may be included in the figures for all respiratory neoplasms.Current estimations, however, give an incidence figure of between three and four per 100,000 population and a sex ratio of 10: 1. BRinEsH
Abnormal Immune Response to Keyhole Limpet Hemocyanin (KLH) in Patients with Multiple Myeloma.
Authors: Jules Harris
Journal: Annals of Internal Medicine (1969)

s1 May 1969Abnormal Immune Response to Keyhole Limpet Hemocyanin (KLH) in Patients with Multiple Myeloma.Jules Harris, M.D., F.A.C.P., Raymond Alexanian, M.D., Evan M. Hersh, M.D., Philip Migliore, M.D.Jules Harris, M.D., F.A.C.P.Search for more papers by this author, Raymond Alexanian, M.D.Search for more papers by this author, Evan M. Hersh, M.D.Search for more papers by this author, Philip Migliore, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1084_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty-three patients (11 men with age range of 56 to 81 years—median, 62; 12 women with age range of 39 to 78 years—median, 62) with multiple myeloma were immunized with 5 mg keyhole limpet hemocyanin given subcutaneously. The distribution of myeloma protein types was as follows: gamma GK, 8 patients; gamma G L, 6; gamma A K, 2; gamma A L, 3; Bence Jones protein only: K, 3 and L, 1. Humoral antibody formation of 7S and 19S type, in vivo delayed hypersensitivity, and in vitro lymphocyte transformation were studied serially. Nine of 11 patients studied developed normal diameter skin... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Houston, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmunodeficiency States Associated with Acute Leukemias, Multiple Myeloma, and Waldenström’s MacroglobulinemiaLymphocyte Abnormalities in Myeloma 1 May 1969Volume 70, Issue 5Page: 1084-1084KeywordsAntibody responseHypersensitivityImmune responseLymphocytesMultiple myelomaMyelomaProteins Issue Published: 1 May 1969 PDF DownloadLoading ...
Ion Channels — Molecular Divining Rods Hit Their Clinical Mark
Authors: Eric P. Hoffman, Kathy Gardner
Journal: New England Journal of Medicine (1997)

Two interesting papers on ion channels appear in this issue of the Journal. In the first, Splawski et al.1 describe the clinical manifestations of a mutation in an ion-channel gene in an extended family. A young girl with congenital hearing loss and severe cardiac dysrhythmia was found to have lost a specific potassium channel (she was homozygous for mutations in KVLQT1), whereas many of her family members had mild prolongation of the QT interval on the electrocardiogram and were heterozygous carriers of the same mutant gene. In the second article, Ackerman and Clapham2 provide a review of ion-channel structure . . .
A Child With Burkitt Lymphoma With Pleural, Peritoneal, Mesenteric, Omental, and Renal Involvement
Authors: Xiaoyan Wang, Zhifeng Chen, Ganghua Tang, Xiangsong Zhang
Journal: Clinical Nuclear Medicine (2011)

A 7-year-old boy presented with increasing abdominal girth and abdominal pain. Abdominal ultrasound revealed a pleural effusion and ascites. Computed tomography (CT) demonstrated a mass involving the peritoneum, mesentery, and omentum with marked ascites, mesenteric nodules, and renal involvement. Positron emission tomography (PET)/CT scan identified additional tumor within the pleura. PET/CT imaging was helpful in identifying the appropriate pleural mass biopsy site in this patient with Burkitt lymphoma.
New Labour and the NHS
Authors: C. Ham
Journal: BMJ (1999)

The effect of diazepam on thyroid function tests was examined in 12 euthyroid patients requiring the drug for psychiatric reasons and in six patients with thyrotoxicosis. Assessment was made before and after four weeks9 therapy. There was no significant difference in results from tests of thyroid iodide trapping and binding (thyroid radioiodine uptake, thyroid clearance, and absolute iodine uptake) except in the one-hour thyroid uptake in the euthyroid group, which was increased after diazepam. This increase occurred without alteration in serum thyroid stimulating hormone levels. No change occurred in either group in tests of thyroid hormone release (protein-bound iodine, T-3 resin uptake, or Thyopac-3 and free thyroxine index). Patients with suspected thyroid disease who are taking diazepam do not need to stop therapy while their thyroid status is being determined.
The Videodisc Encyclopedia of Medical Images
Authors: Christine Chastain-Warheit
Journal: JAMA (1993)

How many file drawers would it take to hold 12 440 35-mm slides? And how should they be indexed for quick access and culled for  particular learning experience?  Films for the Humanities & Sciences has put together  videodisk encyclopedia of medical images, a comprehensive medical resource for research, teaching and self-directed learning. The images are of uniformly high quality; what you see is what you're supposed to see.  The images are arranged according to the International Classificaton of Diseases , 9th edition (ICD-9), by chapter, from Infectious and Parasitic Disease through External Causes of Injuries and Poisonings. There are even  few historical images, such as Fleming's culture plate. And there is one lovely image of  primrose, Primula obconica , in full bloom; apparently it's  very allergenic plant. Anyone who wants to see what chickenpox looks like, or smallpox, leprosy, lupus, or orf can find excellent illustrations. The
Cardiotoxicity of Cancer Therapy
Authors: Justin D. Floyd, Duc T. Nguyen, Raymond L. Lobins, Qaiser Bashir, Donald C. Doll, Michael C. Perry
Journal: Journal of Clinical Oncology (2005)

Because cancer is a leading cause of mortality in the United States, the number of therapeutic modalities available for the treatment of neoplastic processes has increased. This has resulted in a large number of patients being exposed to a wide variety of cancer therapy. Historically, it has been well recognized that antineoplastic agents may have adverse effects on multiple organs and normal tissues. The most commonly associated toxicities occur in tissues composed of rapidly dividing cells and may spontaneously reverse with minimal long-term toxicity. However, the myocardium consists of cells that have limited regenerative capability, which may render the heart susceptible to permanent or transient adverse effects from chemotherapeutic agents. Such toxicity encompasses a heterogeneous group of disorders, ranging from relatively benign arrhythmias to potentially lethal conditions such as myocardial ischemia/infarction and cardiomyopathy. In some instances, the pathogenesis of these toxic effects has been elucidated, whereas in others the precise etiology remains unknown. We review herein the various syndromes of cardiac toxicity that are reported to be associated with antineoplastic agents and discuss their putative mechanisms and treatment.
Reliability of video taped interviews with children suspected of being sexually abused.
Authors: M. R. Wiseman, E. Vizard, A. Bentovim, J. Leventhal
Journal: BMJ (1992)

To determine the reliability of judgments about the likelihood of child sexual abuse based only on video recorded interviews.Blinded rating of likelihood of abuse by seven professional groups and comparison with consensus rating.Child and adolescent psychiatry centre.Four people from each of seven professional disciplines: specialist psychiatrists, general psychiatrists, experimental psychologists, trainee social workers, trainee clinical psychologists, lawyers, and police.Rating of 12 recorded interviews.Agreement between the consensus panel and professional groups was 83% (151/183) for high likelihood cases (seven cases) and 89% (118/132) for low likelihood cases (five). Specialist psychiatrists and the police were better able to identify high likelihood cases than were other groups with less experience of interviewing sexually abused children (91% (48/53) v 79% (102/129); p = 0.05).Raters could accurately distinguish children with low likelihood of abuse on interview evidence alone, but those with more experience of dealing with sexual abuse were better at identifying high likelihood cases.