tbuckley/cabot-search huggingface dataset:
Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices.
Authors: R A Clark, J M Folkvord, C E Hart, M J Murray, J M McPherson
Journal: Journal of Clinical Investigation (1989)

Fibroplasia and angiogenesis are essential components of tissue repair when substantial tissue has been lost at a site of injury. Platelets and monocyte/macrophages accumulate at these sites and release a variety of growth factors that are thought to initiate and sustain the repair. Often the involved tissue contracts, a process that can markedly reduce the amount of fibroplasia and angiogenesis necessary for the reestablishment of organ integrity. Such tissue contraction occurs over hours or days, a much slower time course than the rapid, reversible contraction of muscle tissue. Fibroblasts, which are rich in f-actin bundles, appear to be responsible for wound contraction. However, the signals that stimulate contraction are not known. Using cultured fibroblasts, which are also rich in f-actin bundles, we demonstrate the platelet and monocyte isoforms of platelet-derived growth factor (PDGF; AB and BB) but not PDGF-AA, can stimulate fibroblasts to contract collagen matrix in a time course similar to that of wound contraction. In addition, PDGF appears to be the predominant fibroblast/collagen gel contraction activity released from platelets. Vasoactive agonists known to stimulate smooth and striated muscle contraction do not stimulate fibroblast-driven collagen gel contraction.
Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial
Authors: Corey Cutler, Haesook T. Kim, Bhavjot Bindra, Stefanie Sarantopoulos, Vincent T. Ho, Yi-Bin Chen, Jacalyn Rosenblatt, Sean McDonough, Phandee Watanaboonyongcharoen, Philippe Armand, John Koreth, Brett Glotzbecker, Edwin Alyea, Bruce R. Blazar, Robert J. Soiffer, Jerome Ritz, Joseph H. Antin
Journal: Blood (2013)
Catabolism of serum gamma G-globulins in a cancer patient and a normal volunteer.
Authors: D E Tee, J Watkins
Journal: BMJ (1967)

Volunteers and MethodsTwo male volunteers were used in this study.The control subject was one of us (J.W.) aged 31.The other volunteer was a patient aged 43, who over the previous seven years had undergone surgery for the removal of six distinct primary carcinomas.
Successful gene therapy of the Gunn rat byin vivo neonatal hepatic gene transfer using murine oncoretroviral vectors
Authors: Marta Bellodi‐Privato, Dominique Aubert, Virginie Pichard, Anne Myara, François Trivin, Nicolas Ferry
Journal: Hepatology (2005)

Crigler-Najjar type 1 disease (CN1) is a rare inherited metabolic disease characterized by complete absence of hepatic UDP-glucuronosyl transferase (UGT1), resulting in high levels of unconjugated bilirubin. CN1 is an attractive candidate disease for gene therapy. Here we show that in vivo neonatal hepatocyte transduction using recombinant oncoretroviral vectors results in long-term and complete phenotype correction in Gunn rats, a model for CN1. Two-day-old newborn Gunn rats were injected via the temporal vein with 200 μL UGT1 or control β-galactosidase retroviral vectors. In UGT1-injected animals, bilirubinemia was normal at 6 weeks (3 μmol/L) and remained in the normal range (i.e., <10 μmol/L) for more than 34 weeks. In contrast, in β-galactosidase–injected animals as well as in noninjected controls, bilirubinemia remained at a high level (i.e., >100 μmol/L) during the whole experimental follow-up. Large amounts of bilirubin monoglucuronides and diglucuronides were present in the bile of treated animals. Finally, polymerase chain reaction and reverse transcription polymerase chain reaction analysis as well as Western blot confirmed the presence and expression of UGT1 almost exclusively in the liver. The estimated proportion of transduced hepatocytes was in the range of 5% to 10%. In conclusion, complete and permanent correction of hyperbilirubinemia in newborn Gunn rats using retroviral vectors can be obtained, paving the way for future gene therapy for CN1. (HEPATOLOGY 2005;42:431–438.)
Diagnosis and management of 528 abdominal aortic aneurysms.
Authors: J W Fielding, J Black, F Ashton, G Slaney, D J Campbell
Journal: BMJ (1981)

Between 1960 and 1979 528 patients with abdominal aortic aneurysms presented to the university department of surgery. Of these, 222 (42%) were elective cases, 72 acute (14%), 174 had ruptured (33%), and four had had a spontaneous aortoduodenal fistula (1%). In all these patients resections were undertaken, but in another 56 patients (11%) the aneurysm was not resected. A review of these cases showed that 91% had symptoms at their first presentation; abdominal pain and backache being most common. The diagnosis could be established in 91% by the presence of pulsatile abdominal mass on clinical examination. The operative mortality for elective resection was 8%, for acute 19%, for ruptured cases 42%, and for spontaneous aortoduodenal fistula 50%. After successful resection the overall five-year survival was 65% by the life table method, and there was no significant difference between elective, acute, and ruptured cases. This five-year survival after resection compares favourably with the expected 76% survival of a similar normal population, and was considerably better than that for conservatively treated patients. As most cases have symptoms, and diagnosis may be established easily by routine physical examination in 91%, the prognosis for this condition could be considerably improved by increased awareness of its existence and early referral for treatment as an elective surgical procedure.
975-77 Gender Associated Differences in Asymptomatic Aortic Stenosis: Exercise Capacity, Functional Status, and Diastolic Left Ventricular Filling
Authors: Malcolm E. Legget, Alan S. Pearlman, Nancy L. Healy, Carolyn Y. Miyake-Hull, Carol D. Kraft, Catherine M. Otto
Journal: Journal of the American College of Cardiology (1995)
Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization
Authors: Takayuki Asahara, Donghui Chen, Tomono Takahashi, Koshi Fujikawa, Marianne Kearney, Meredith Magner, George D. Yancopoulos, Jeffrey M. Isner
Journal: Circulation Research (1998)

Abstract —Angiopoietin-1 (Ang1) has been recently identified as the major physiological ligand for the tyrosine kinase receptor Tie2 and assigned responsibility for recruiting and sustaining periendothelial support cells. Angiopoietin-2 (Ang2) was found to disrupt blood vessel formation in the developing embryo by antagonizing the effects of Ang1 and Tie2 and was thus considered to represent a natural Ang1/Tie2 inhibitor. In vivo effects of either angiopoietin on postnatal neovascularization, however, have not been previously described. Accordingly, we used the cornea micropocket assay of neovascularization to investigate the impact of angiopoietins on neovascularization in vivo. Neither Ang1 nor Ang2 alone promoted neovascularization. Pellets containing vascular endothelial growth factor (VEGF) alone induced corneal neovascularity extending from the limbus across the cornea. Addition of Ang1 to VEGF (Ang1+VEGF) produced an increase in macroscopically evident perfusion of the corneal neovasculature without affecting macroscopic measurements of length (0.58±0.03 mm) or circumferential neovascularity (136±10°). In contrast, pellets containing Ang2+VEGF promoted significantly longer (0.67±0.05 mm) and more circumferential (160±15°) neovascularity than VEGF alone or Ang1+VEGF ( P &lt;0.05). Excess soluble Tie2 receptor (sTie2-Fc) precluded modulation of VEGF-induced neovascularization by both Ang2 and Ang1. Fluorescent microscopic findings demonstrated enhanced capillary density (fluorescence intensity, 2.55±0.23 e +9 versus 1.23±0.17 e +9 , P &lt;0.01) and increased luminal diameter of the basal limbus artery (39.0±2.8 versus 27.9±1.3 μm, P &lt;0.01) for Ang1+VEGF compared with VEGF alone. In contrast to Ang1+VEGF, Ang2+VEGF produced longer vessels and, at the tip of the developing capillaries, frequent isolated sprouting cells. In the case of Ang2+VEGF, however, luminal diameter of the basal limbus artery was not increased (26.7±1.9 versus 27.9±1.3, P =NS). These findings constitute what is to our knowledge the first direct demonstration of postnatal bioactivity associated with either angiopoietin. In particular, these results indicate that angiopoietins may potentiate the effects of other angiogenic cytokines. Moreover, these findings provide in vivo evidence that Ang1 promotes vascular network maturation, whereas Ang2 works to initiate neovascularization.
New Combination Drug for HIV
Authors: Jane E. Henney
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aspirin for the Prevention of Cardiovascular Events in Patients With Peripheral Artery Disease
Authors: Jeffrey S. Berger, Mori J. Krantz, John M. Kittelson, William R. Hiatt
Journal: JAMA (2009)

<h3>Context</h3>Randomized trials have shown that aspirin decreases the risk of cardiovascular events in patients with symptomatic coronary and cerebrovascular disease. Despite guideline recommendations for secondary prevention in peripheral artery disease (PAD), the effect of aspirin in this population is not well established.<h3>Objective</h3>To investigate the effect of aspirin on cardiovascular event rates in patients with PAD.<h3>Data Sources and Study Selection</h3>MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, Science Citation Index (1966 to December 2008), and unpublished studies from the supplemental index of the Antithrombotic Trialists' Collaboration. Eligible studies were prospective, randomized controlled trials of aspirin therapy, with or without dipyridamole that reported cardiovascular event rates. Eighteen trials involving 5269 individuals were identified.<h3>Data Extraction</h3>Studies were reviewed to determine the number of participants, mean follow-up, and the primary end point of cardiovascular events (nonfatal myocardial infarction [MI], nonfatal stroke, and cardiovascular death). Data on the secondary end points of all-cause mortality, major bleeding, and the individual components of the primary outcome measure were also abstracted. For the primary end point, the analysis had 88% power to detect a 25% reduction and 70% power to detect a 20% reduction in cardiovascular events in the aspirin group compared with the control group.<h3>Data Synthesis</h3>Among 5269 participants, cardiovascular events were experienced by 251 (8.9%) of 2823 patients taking aspirin (alone or with dipyridamole) and by 269 (11.0%) of 2446 in the control group (pooled relative risk [RR], 0.88; 95% confidence interval [CI], 0.76-1.04). Aspirin therapy was associated with a reduction in the secondary outcome of nonfatal stroke (52 of 2823 vs 76 of 2446; RR, 0.66; 95% CI, 0.47-0.94) but was not associated with significant reductions in all-cause or cardiovascular mortality, MI, or major bleeding. In the subset of 3019 participants taking aspirin alone vs control, aspirin was associated with a nonsignificant reduction in cardiovascular events (125 of 1516 vs 144 of 1503; RR, 0.75; 95% CI, 0.48-1.18), a significant reduction in nonfatal stroke (32 of 1516 vs 51 of 1503; RR, 0.64; 95% CI, 0.42-0.99), but no statistically significant reductions in all-cause or cardiovascular mortality, MI, or major bleeding.<h3>Conclusions</h3>In patients with PAD, treatment with aspirin alone or with dipyridamole resulted in a statistically nonsignificant decrease in the primary end point of cardiovascular events and a significant reduction in nonfatal stroke. Results for the primary end point may reflect limited statistical power. Additional randomized controlled trials of aspirin therapy are needed to establish the net benefit and bleeding risks in PAD.
PYELITIS OF PREGNANCY
Authors: HERMAN L. KRETSCHMER
Journal: JAMA (1923)

Pyelitis as an obstetric complication should include not only the cases that occur during pregnancy, but also the cases that begin during the puerperium. Although the cases that occur during pregnancy outnumber those beginning in the puerperium, it seems desirable that they should be discussed together.  Pyelitis occurring during pregnancy assumes a more serious aspect than does a simple case of pyelitis, since it concerns not only the patient, but the fetus as well, and, moreover, may influence unfavorably the course of the pregnancy.  PREDISPOSING CAUSES  Some of the predisposing causes are common both to simple pyelitis and to the pyelitis of pregnancy. In addition to these causes, there are certain predisposing factors which are directly due to, or associated with, the pregnancy.  Lesions of the Gastro-Intestinal Tract.  —It has repeatedly been pointed out that lesions of the gastro-intestinal tract are most important predisposing factors; constipation undoubtedly heads the list.
NVP019 POTENTLY INHIBITS CYCLOPHILIN D-DEPENDENT MITOCHONDRIAL PERMEABILITY TRANSITION IN HUMAN HEART AND REDUCES MYOCARDIAL INFARCT SIZE IN MICE
Authors: Bruno Pillot, Sarah Piel, François Derimay, Abdallah Gharib, Magnus J. Hansson, Michel Ovize
Journal: Journal of the American College of Cardiology (2015)
Six year review of the results of freehand aortic valve replacement using an antibiotic sterilized homograft valve.
Authors: B G Barratt-Boyes, A H Roche, R M Whitlock
Journal: Circulation (1977)

The long-term behavior of an antibiotic-treated homograft aortic valve inserted in a freehand fashion was assessed in 121 patients operated upon for aortic valve disease and followed from four to six and one-half years. There were seven hospital deaths (5.7%) and 30 late deaths, only one of which was related to the homograft valve. The six year survival was 69% (77% for single valve and 52% for multiple valve surgery). At six years 9% had important homograft aortic valve incompetence (HAVI) and most of these required reoperation. Important HAVI occurred in only 5% of patients with an aortic root diameter less than 24 mm and in 38% of those with a markedly dilated or distorted proximal aorta (P less than 0.01). The freehand aortic homograft was considered superior to prosthetic devices because of the absence of chronic anticoagulation, thromboembolism, sudden death from valve failure and significant obstruction in a small aortic root. With slightly restricted patient selection the valve failure rate is expected to fall to less than 1% per year.
Human Pyrimidine Metabolism
Authors: Sherman M. Weissman
Journal: JAMA (1966)

Studies of pyrimidine metabolism in man have assumed interest in recent years with the recognition of specific alterations in their synthesis and excretion in certain diseases. Further, several pyrimidine antimetabolites have been introduced into cancer chemotherapy, and the metabolic alterations produced by some of these, 6-azauridine, has been a subject of physiological and biochemical interest. The pyrimidine ring is a common component of biologically active substances. It occurs in a variety of therapeutic compounds such as xanthine oxidase inhibitors, antimetabolites, antithyroid substances, sedatives, and vitamins. Among natural substances, pyrimidines occur most abundantly in the nucleic acids. Ribonucleic acids contain large amounts of uracil and cytosine derivatives (Fig 1), and deoxyribonucleic acid (DNA) contains cytosine and thymine derivatives (Fig 1). Pyrimidines also appear in a variety of acid-soluble phosphorylated cofactors, such as uridine diphosphoglucose, which play a central role in carbohydrate and lipid metabolism. <h3>Normal Pyrimidine Metabolism</h3> The pathway of pyrimidine
Saying the Grace for Sharon
Authors: Alison Kolodinsky
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors' reply to Magrini and colleagues
Authors: C. Barbui, M. Purgato
Journal: BMJ (2014)

We thank Magrini and colleagues for their response to our article on the World Health Organization’s essential medicines process.1 As strong supporters of WHO’s role, we are pleased that some of the problems we raised reflect internal discussions at WHO on how to strengthen the selection process for WHO’s list of essential medicines.2

However, we …
Bile Leakage Accumulating in the Gallbladder Bed Mimicking Normal Visualization of Gallbladder in Technetium-99m Disida Hepatobiliary Imaging
Authors: WEI-JEN SHIH, DENISE DUFF, LEONIDAS MOSTOWYCZ
Journal: Clinical Nuclear Medicine (1989)

A bile leak is defined as an accumulation of radiotracer outside of the normal distribution in hepatobiliary imaging. A patient with a history of cholecyslectomy underwent Tc-99m DISIDA imaging, which showed radiotracer accumulation in the gallbladder bed mimicking normal visualization of the gallbladder within 1 hour; the area of activity was then dispersed along the inferior border of the liver in the 3-hour image. Subsequent exploratory laparotomy confirmed bile leakage.
Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia
Authors: Rukhsana Aslam, Yu Hu, Simon Gebremeskel, George B. Segel, Edwin R. Speck, Li Guo, Michael Kim, Heyu Ni, John Freedman, John W. Semple
Journal: Blood (2012)
Inhibition of Binding of Tritiated Digoxin to Myocardium by Sodium Depletion in Dogs
Authors: CARLOS E. HARRISON, KHALIL G. WAKIM
Journal: Circulation Research (1969)

Ten intact dogs were subjected to hemodialysis against a solution of low-sodium content to determine the influence of sodium depletion on myocardial binding of digoxin- 3 H. Serial determinations of serum sodium, potassium, chloride, bicarbonate, pH, and osmolality, of cardiac output, and of cardiac rhythm were obtained in these and in 10 control dogs dialyzed against the standard solution. A dose of digoxin- 3 H (0.05 mg/kg) was given intravenously after start of the dialysis and the animals were killed 1 hour afterward for measurement of myocardial radioactivity, potassium, and sodium. Significant depletion of serum sodium and chloride and myocardial sodium ( P &lt; 0.001) occurred in all animals dialyzed against the low-sodium solution. No significant changes occurred in other serum electrolytes or pH; osmolality was maintained constant by a slow intravenous drip of 25% urea or mannitol. Myocardial radioactivity was reduced in sodium-depleted animals by 50% ( P &lt; 0.001). The Na-K ratio was 0.40 in the myocardium of control animals and 0.26 in sodium-depleted animals. It was concluded that depletion of body sodium inhibits binding of digitalis glycosides to the myocardium during the first hour after injection of the dose.
Losing the moment
Authors: D. Spence
Journal: BMJ (2010)

Life is tedious monotony interspersed with occasional memorable moments. My wife and I have never stood on the bow of a ship pretending to fly, nor have I wrapped my arm around her while making a clay pot on a potter’s wheel; but like everyone else I have my own memorable moments. Memorable moments are more frequent when we are young and are woven of optimism, recklessness, youthful invincibility, and an overwhelming sense of wellness—a sense more mental than physical. The rest of life is spent …
Detecting Cryptosporidiosis as a Cause of Diarrheal Illness: Implications for Clinicians
Authors: Thomas R. Navin
Journal: JAMA (1997)

<h3>To the Editor.</h3> —In response to numerous waterborne outbreaks of cryptosporidiosis, including 1 in Milwaukee in 1993 that affected an estimated 403 000 persons,<sup>1</sup>the Centers for Disease Control and Prevention (CDC), in collaboration with other federal agencies, state and local health departments, and other interested parties, formed the Working Group on Waterborne Cryptosporidiosis (WGWC). One of the WGWC's objectives has been to develop guidelines for water utilities, health departments, and others about how to prepare for and respond to future waterborne outbreaks. The WGWC's guidelines for microbiology laboratories have been published,<sup>2</sup>and although they are directed at laboratory professionals, the guidelines have important implications for clinicians as well. The WGWC recognized that an obstacle to the early detection of outbreaks of cryptosporidiosis was poor communication between microbiology laboratories and health care professionals. Clinicians often make the erroneous assumption that a request for ova and parasite testing includes
On Dilatation of the Heart, Consequent upon Teetotalism
Authors: Richard Chambers
Journal: BMJ (1846)

O DILATATIWO Th14 HtART.are vigorous and strong enough in their second year to be turned into the ponds, where they would probably shift for themnselves.fThe leech is a very prolific animal, and it is probable that some thousands might be reared every year, in-