Familial Breast Cancer, Soft-Tissue Sarcomas, and Other Neoplasms
Authors: FREDERICK P. LI
Journal: Annals of Internal Medicine (1975)

Letters1 December 1975Familial Breast Cancer, Soft-Tissue Sarcomas, and Other NeoplasmsFREDERICK P. LI, M.D., JOSEPH F. FRAUMENI JR., M.D., F.A.C.P.FREDERICK P. LI, M.D., JOSEPH F. FRAUMENI JR., M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-833_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1969, we described in 4 families (A through D) a syndrome of soft-tissue sarcomas, breast cancer, and other neoplasms affecting children and young adults (1). We present the findings on follow-up of families A, B, and C. Family D has been lost to contact.During the past 7 years, 8 of approximately 50 surviving members of the three families have been diagnosed with new malignancies. In Family C breast cancer developed in both sisters of a pair of male siblings with childhood sarcoma (Figure 1). Patient IV-3 had adenocarcinoma of the right breast at age 32 years, while patient...References1. LIFRAUMENI FJ: Soft-tissue sarcomas, breast cancer, and other neoplasms: a familial syndrome? Ann Intern Med 71:747-752, 1969 LinkGoogle Scholar2. BOTTOMLEYTRAINERCONDIT RAP: Chromosome studies in a "cancer family." Cancer 28:519-528, 1971 CrossrefMedlineGoogle Scholar3. BUEHLERFODORMARSHALL SGW: Common variable immunodeficiency, Hodgkin's disease, and other malignancies in a Newfoundland family. Lancet 1:195-197, 1975 CrossrefMedlineGoogle Scholar4. FRAUMENIWERTELECKIBLATTNER JWW: Varied manifestations of a familial lymphoproliferative disorder. Am J Med 59:145-151, 1975 CrossrefMedlineGoogle Scholar5. CREAGANFRAUMENI EJ: Familial gastric cancer and immunologic abnormalities. Cancer 32:1325-1331, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FREDERICK P. LI, M.D.; JOSEPH F. FRAUMENIJR., M.D., F.A.C.P.Affiliations: Epidemiology Branch National Cancer Institute Landow A521 Bethesda, Maryland 20014 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA 62-Year-Old Woman With Osteogenic Sarcoma in the Contralateral Breast 15 Years After Treatment for Breast CancerBreast Cancer GeneticsSecond Tumors after Radiosurgery: Tip of the Iceberg or a Bump in the Road?Sarcoma as a second malignancy after treatment for breast cancerBrain and Central Nervous System CancerMultiple primary malignancies in association with soft tissue sarcomasPredominance of brain tumors in an extended Li-Fraumeni (SBLA) kindred, including a case of Sturge-Weber syndromeBreast cancer genetics: Family history, heterogeneity, molecular genetic diagnosis, and genetic counselingFamilial versus sporadic breast cancerThe Molecular and Genetic Characterization of Human Soft Tissue TumorsPostirradiation sarcoma. Analysis of a nationwide cancer registry materialKeynote address: Contributions of pediatric oncology: Examples derived from advances made in the treatment of rhabdomyosarcoma and neuroblastomaGenetic epidemiology of childhood brain tumorsMammographic screening of women with increased risk of breast cancerPrenatal detection of non-cardiac rhabdomyosarcomaMutagen sensitivity and cancer susceptibility. Report of a cancer-prone familySuccessful treatment of a radiation-associated extradural osteosarcoma with chemotherapy in an adolescent girlGenetic risks in cancerGenetics and smoking-associated cancers. A study of 485 familiesGenetic Epidemiology of Familial Aggregation of CancerGenetic epidemiology of breast cancer: Further clarification and a response to King and ElstonCancer in Relatives of Children with Central-Nervous-System NeoplasmsGenetic Problems of Endocrine SignificanceFamilial cancer or cancer family syndrome. Report on a cancer family and consideration of genetic mechanismsRadiogenic Male Breast Cancer with in Vitro Sensitivity to Ionizing Radiation and BleomycinChildhood cancer in offspring of two wilms tumor survivorsBone sarcoma as a second malignant neoplasm in children: Influence of radiation and genetic predispositionGenetics and cancerGenetic and pathologic findings in a kindred with hereditary sarcoma breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinomaProgress and controversy in the treatment of childhood rhabdomyosarcomaGenetic and environmental interactionsGenetic etiology of cancer 1 December 1975Volume 83, Issue 6Page: 833-834KeywordsAdenocarcinomaBreast cancerChildrenPatient advocacySarcomaYoung adults ePublished: 1 December 2008 Issue Published: 1 December 1975 PDF downloadLoading ...