tbuckley/cabot-search huggingface dataset:
Cytokine profile during high‐dose rhG‐CSF therapy in severe congenital neutropenia
Authors: Toshiji Shitara, Shin‐Ichiroh Yugami, Hiroko Ijima, Manabu Sotomatu, Takayoshi Kuroume
Journal: American Journal of Hematology (1994)

Abstract The effect of recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) on cytokine profile was evaluated in a case of severe congenital neutropenia. The plasma levels of cytokines were measured before and during rhG‐CSF therapy. These included G‐CSF, granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), interleukin‐1α, in‐terleukin‐1 β, interleukin‐2 (IL‐2), interleukin‐3 (IL‐3), interleukin‐4, interleukin‐6 (IL‐6), and tumor necrosis factor‐α. Soluble Interleukin‐2 receptor (sIL‐2R) was measured serially during rhG‐CSF therapy. Lymphocyte subpopulations Including CD2, CD3, CD4, CD8, CD19, CD20, and CD25 were also measured, rhG‐CSF was administered once daily as a 30‐min infusion. The patient was treated with Increasing dose levels of 100,200,400, 800, and 1,600 μg/m 2 /day. The level of endogenous G‐CSF was elevated to 334 pg/ml before treatment and GM‐CSF, IL‐2, IL‐3, and IL‐6 were slightly elevated. Clinically, he showed a moderate response to a high dose of rhG‐CSF (1,600 μg/m 2 /day). Plasma levels of G‐CSF markedly Increased during therapy but plasma levels of other cytokines did not show significant changes during therapy and iymphocyte subpopulations did not significantly change. A drastic Increase in siL‐2R expression was observed after rhG‐CSF infusion and an Increase in siL‐2R expression occurred even before a major increase in granulocyte counts. These results showed that a high dose rhG‐CSF therapy may influence the cytokine network as judged by the increased slL‐2R expression. © 1994 Wiley‐Liss, Inc.
Dutch doctor who was jailed for culpable homicide has his sentence cut
Authors: Tony Sheldon
Journal: BMJ (2005)

A former paediatric cardiologist in Holland who was jailed for culpable homicide aftera 7 month old girl died from complications of a heart catheterisation has had his sentence reduced on appeal. Under Dutch law the names of defendants are not disclosed, so the doctor is known only as Dr Paul H.

The Arnhem Appeal Court reduced his six year ban on practising medicine to a suspendedthree year ban on condition that he did not work in paediatrics, and it reduced his 18 month prison sentence to six months, four of which were suspended. Dr H was also convicted of possessing a large amount …
Cabinet rules that South Africans must be given antiretrovirals
Authors: P. Sidley
Journal: BMJ (2003)

The South African cabinet announced at the end of last week that it has ordered the health minister, Dr Manto Tshabalala-Msimang, to compile a plan for the roll out of anti-retroviral treatment for people with HIV and AIDS.

The announcement comes after a report drawn up by the Ministries of Health and Finance that shows that the country can afford to make the drugs available and that up to 1.7 million lives could be significantly prolonged by the treatment. Some of the finance and expertise, …
Thrombosis in Antithrombin-III Deficiency
Authors: Valerio De Stefano, Giuseppe Leone
Journal: Annals of Internal Medicine (1992)

Letters15 November 1992Thrombosis in Antithrombin-III DeficiencyValerio De Stefano, MD, Giuseppe Leone, MDValerio De Stefano, MDSearch for more papers by this author, Giuseppe Leone, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-10-875_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Demers and colleagues (1) reported on the prevalence of thrombosis in antithrombin-III-deficient patients. They analyzed 31 patients from a large kindred and another 449 patients from 62 kindreds described in the literature. All had antithrombin-III quantitative deficiency or impairment in serine protease inactivation; families with isolated disturbance in heparin binding were not included. The pooled prevalence of venous thrombosis was found to be 51%.We analyzed 552 patients affected with (n= 344) or at high risk (0.5) for antithrombin-III deficiency (n= 208) and belonging to 40 different kindreds. Of 120 recorded deaths, 44 (36.7%) were...References1. DemersGinsbergHirshHendersonBlajchman CJJPM. Thrombosis in antithrombin-III-deficient persons. Report of a large kindred and literature review. Ann Intern Med. 1992;116:754-61. LinkGoogle Scholar2. De StefanoLeone VG. Mortality related to thrombosis in congenital antithrombin-III deficiency. Lancet. 1991;1:847-8. CrossrefGoogle Scholar3. RosendaalHeijboerBriet FHE. Mortality in hereditary antithrombin-III deficiency—1830 to 1989. Lancet. 1991;1:260-2. CrossrefGoogle Scholar4. FinazziBarbui GT. A retrospective study on oral anticoagulant prophylaxis in 103 Italian patients with hereditary thrombophilia and thrombosis. Res Clin Lab. 1990;20:245-52. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Istituto di Semeiotica Medica Università Cattolica00168 Rome, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1992Volume 117, Issue 10Page: 875-875KeywordsHeparinSerine proteasesThrombosis ePublished: 1 December 2008 Issue Published: 15 November 1992 PDF downloadLoading ...
Starvation in Man
Authors: Louis M. Sherwood, Edith E. Parris, George F. Cahill
Journal: New England Journal of Medicine (1970)

ALTHOUGH it has been known for over a century that fat is the principal storage form of energy, only in the past two decades have the physiologic mechanisms for its deposition and mobilization been partially clarified. Benedict,1 in his classic study on Mr. L., a normal man who over 50 years ago fasted experimentally for 30 days, noted that fat provided more than 75 per cent of the calories utilized after the first few days of food deprivation. He also observed a progressive decrease in daily urinary nitrogen excretion that suggested an increasing conservation of body protein. In this review . . .
Locoregional Multiple Nodular Panniculitis Induced by<i>Pseudomonas aeruginosa</i>Without Septicemia
Authors: Mélanie Roriz, Annabel Maruani, Emmanuelle Le Bidre, Marie-Christine Machet, Laurent Machet, Mahtab Samimi
Journal: JAMA Dermatology (2014)

Pseudomonas aeruginosa-induced locoregional multiple nodular panniculitis without septicemia is an underreported condition, with only 3 cases reported to date. We report 3 new cases of P aeruginosa-induced multiple nodular panniculitis without septicemia and describe common features among all 6 cases, thus providing the first description, to our knowledge, of the natural history and potential predisposing factors for this entity.Median age of the 6 patients was 74 years (range, 54-84 years). Patients had inflammatory nodules on a lower limb (n = 6) that were unilateral (n = 6) and had no fever (n = 5). Blood cultures were negative (n = 5). Skin biopsy specimens revealed panniculitis (n = 5), with skin cultures positive for P aeruginosa (n = 6). Skin nodules resolved with systemic antibiotics (n = 5). The comorbidities recorded were type 1 or 2 diabetes mellitus (n = 5), overweight (n = 3), and combined locoregional anatomical changes in the lower limbs (n = 5). Local skin injury, which constituted the portal entry, was present in all cases, especially leg ulcers (n = 3).We describe P aeruginosa-induced locoregional nodular panniculitis as a distinct entity. This should be investigated in elderly, diabetic, overweight patients with inflammatory nodules on a lower limb associated with locoregional anatomical changes and skin injury, with the optimal antibiotic regimen introduced as rapidly as possible.
In Defense of The Newborn Cliché
Authors: John T. Flynn
Journal: JAMA (1966)

To the Editor:—  Is it possible to think of a cliche that is not tired? ( 197 :216, 1966). The answer is clearly Yes.  After perusal of Abstracts of Research and Demonstration Projects in Social Welfare and Related Fields , US Department of Health, Education and Welfare, 1965, I can state this firmly.  This is a moving and heartening document. Someone, after all, is giving close attention to the economically deprived, the illegitimate, the mentally retarded, the chronically ill, the aged, the unwed mother, and the street gang.  At an idle midnight hour, this document inspires a host of fantasies, and a trance-like verbosity infuses the mind with a spate of new cliches, meaningless but zestful:  Creative and non-creative accomplishment and its bearing on crosscultural perspectives.  Goal-attainment in the non-achiever. Semantic differentials and their effect upon intragroup structural contrasts.  Parental attitudinizing—a reactive counterforce against offspring resistance to maternal-paternal authority status as it
Glomerular hemodynamics in established glycerol-induced acute renal failure in the rat.
Authors: A I Wolfert, D E Oken
Journal: Journal of Clinical Investigation (1989)

The glomerular dynamic correlates of failed filtration were studied in volume replete rats with established glycerol-induced acute renal failure (ARF). Over one-half of all nephrons formed virtually no filtrate, while the single nephron glomerular filtration rate (SNGFR) of fluid-filled nephrons, measured at the glomerulotubular junction to preclude the possibility of covert tubular leakage, averaged one-sixth of control (P less than 0.001). Even that low mean value was elevated by a few nephrons with a near normal SNGFR. Renal failure thus reflected both total filtration failure in the majority of nephrons and massively reduced filtration in most of the remainder. Glomerular capillary pressure (Pg) averaged some 14 mmHg below control (P less than 0.001), whereas the arterial colloid osmotic and Bowman's space pressures were not significantly altered. Renocortical and whole kidney blood flow were also unchanged. Marked internephron functional heterogeneity precluded estimates of the ultrafiltration coefficient. However, the fall in SNGFR correlated well with the markedly depressed Pg and afferent net filtration pressure (delta PnetA, P less than 0.001), which in turn were caused by increased preglomerular resistance and a reciprocal fall in efferent arteriolar resistance. This complex change in intrarenal resistances was largely, if not entirely, responsible for failed filtration in this ARF model.
Respiratory Symptoms of Obstructive Lung Disease in European Crop Farmers
Authors: EDUARD MONSÓ, RAMÓN MAGAROLAS, KATJA RADON, BRIGITTA DANUSER, MARTIN IVERSEN, CHRISTOPH WEBER, ULRIKE OPRAVIL, KELLEY J. DONHAM, DENNIS NOWAK
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Crop farming as a risk factor for respiratory symptoms of obstructive lung disease was assessed. Random samples of crop farmers from four European countries were studied following a cross-sectional design. A questionnaire on respiratory symptoms and occupation was administered to determine prevalences, and the roles of the various crops as risk factors for respiratory symptoms were assessed through logistic regression modeling. The 4,793 crop farmers included in the study (response rate: 85.3%) reported the following respiratory symptoms: wheezing (14.9%), asthma (3.3%), nasal allergy (14.4%), chronic phlegm (12.4%), organic dust toxic syndrome (ODTS) (15.2%), and symptoms at work (22.0%). In the multivariate analysis, adjusting for age, sex, smoking, country, and exposure to other plants or livestock, flower growing was a risk factor for asthma (odds ratio [OR] 2.1, 95% confidence interval [CI] 1.1–3.9) and cultivating oil plants was associated with ODTS (OR 1.5, 95% CI 1.3–1.9), symptoms at work (OR 1.4, 95% CI 1.2– 1.7), and chronic phlegm (OR 1.3, 95% CI 1.1–1.6). Working inside greenhouses was a marginal risk factor for asthma (OR 2.1, 95% CI 0.9–4.5). We conclude that flower and oil plant production is associated with increased risk of respiratory symptoms in European crop farmers.
Fatty acid binding protein. Role in esterification of absorbed long chain fatty acid in rat intestine.
Authors: R K Ockner, J A Manning
Journal: Journal of Clinical Investigation (1976)

Fatty acid binding protein (FABP) is a protein of 12,000 mol wt found in cytosol of intestinal mucosa and other tissues, which exhibits high affinity for long chain fatty acids. It has been suggested that FABP (which may comprise a group of closely related proteins of 12,000 mol wt) participates in cellular fatty acid transport and metabolism. Although earlier findings were consistent with this concept, the present studies were designed to examine its physiological function more directly. Everted jejunal sacs were incubated in mixed fatty acid-monoglyceride-bile acid micelles, in the presence or absence of equimolar concentrations of either of two compounds which inhibit oleate binding to FABP:flavaspidic acid-N-methyl-glucaminate and alpha-bromopalmitate. Oleate uptake, mucosal morphology, and oxidation of [14C]acetate remained unaffected by these agents, but oleate incorporation into triglyceride was inhibited by 62-64% after 4 min. The inhibition by flavaspidic acid was reversible with higher oleate concentrations. The effect of these compounds on enzymes of triglyceride biosynthesis was examined in intestinal microsomes. Neither flavaspidic acid nor alpha-bromopalmitate inhibited acyl CoA:monoglyceride acyl-transferase. Fatty acid:coenzyme A ligase activity was significantly enhanced in the presence of partially purified FABP, probably reflecting a physical effect on the fatty acid substrate or on the formation of the enzyme-substrate complex. Activity of the enzyme in the presence of 0.1 mM oleate was only modestly inhibited by equimolar flavaspidic acid and alpha-bromopalmitate, and this effect was blunted or prevented by FABP. We conclude that in everted gut sacs, inhibition of triglyceride synthesis by flavaspidic acid and alpha-bromopalmitate could not be explained as an effect on fatty acid uptake or on esterifying enzymes in the endoplasmic reticulum but rather can be interpreted as reflecting inhibition of fatty acid binding to FABP. These findings lend further support to the concept that FABP participates in cellular fatty acid transport and metabolism. It is also possible that FABP, by effecting an intracellular compartmentalization of fatty acids and acyl CoA, may play a broader role in cellular lipid metabolism.
Abstract 16602: Safety And Long-Term Outcome of Robotic-Guided Atrial Fibrillation Ablation: Results From the Worldwide Survey
Authors: Rong Bai, Luigi Di Biase, Miguel Valderrabano, Faizel Lorgat, Hanka Mlcochova, Roland Tilz, Udo Meyerfeldt, Patrick M. Hranitzky, Oussama Wazni, Prapa Kanagaratnam, Rahul N. Doshi, Douglas Gibson, André Pisapia, Prasant Mohanty, Walid Saliba, Feifan Ouyang, Josef Kautzner, G. Joseph Gallinghouse, Andrea Natale
Journal: Circulation (2011)

Introductions: The Hansen Robotic system has been utilized in ablation procedures for atrial fibrillation (AF) aiming at minimizing X-ray exposure, improving catheter stability and possibly increas...
Decrease in anti-Proteus mirabilis but not anti-Escherichia coli antibody levels in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet.
Authors: J Kjeldsen-Kragh, T Rashid, A Dybwad, M Sioud, M Haugen, O Forre, A Ebringer
Journal: Annals of the Rheumatic Diseases (1995)

OBJECTIVE--To measure Proteus mirabilis and Escherichia coli antibody levels in patients with rheumatoid arthritis (RA) during treatment by vegetarian diet. METHODS--Sera were collected from 53 RA patients who took part in a controlled clinical trial of fasting and a one year vegetarian diet. P mirabilis and E coli antibody levels were measured by an indirect immunofluorescence technique and an enzyme immunoassay, respectively. RESULTS--The patients on the vegetarian diet had a significant reduction in the mean anti-proteus titres at all time points during the study, compared with baseline values (all p &lt; 0.05). No significant change in titre was observed in patients who followed an omnivorous diet. The decrease in anti-proteus titre was greater in the patients who responded well to the vegetarian diet compared with diet non-responders and omnivores. The total IgG concentration and levels of antibody against E coli, however, were almost unchanged in all patient groups during the trial. The decrease from baseline in proteus antibody levels correlated significantly (p &lt; 0.001) with the decrease in a modified Stoke disease activity index. CONCLUSION--The decrease in P mirabilis antibody levels in the diet responders and the correlation between the decrease in proteus antibody level and decrease in disease activity supports the suggestion of an aetiopathogenetic role for P mirabilis in RA.
An Evaluation Model for Physician Assistants as Instructors of Physical Diagnosis.
Authors: D. H. Kuiper
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972An Evaluation Model for Physician Assistants as Instructors of Physical Diagnosis.D. H. Kuiper, M.D., F.A.C.P., R. E. Darnell, Ph.D., T. M. Johnson, F.A.C.P., F. M. DawsonD. H. Kuiper, M.D., F.A.C.P.Search for more papers by this author, R. E. Darnell, Ph.D.Search for more papers by this author, T. M. Johnson, F.A.C.P.Search for more papers by this author, F. M. DawsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-855_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past academic year an ex-Navy corpsman physician's assistant participated in a pilot research project by serving as an instructor of procedural skills for physical diagnosis to first-year medical students. A system was devised to evaluate whether the physician's assistant's performance was of sufficient caliber to ensure the students attaining a high degree of competency. This evaluation included ratings of student performances by instructors, ratings of the course by the students, ratings of the physician's assistant by the students, and behavioral observations by trained observers. Based on these observations, a number of hypotheses were developed and presented to the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: D. H. Kuiper, M.D., F.A.C.P.; R. E. Darnell, Ph.D.; T. M. Johnson, F.A.C.P.; F. M. DawsonAffiliations: East Lansing, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5 Page: 855-856 ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity
Authors: Shu-Ching Shih, Meihua Ju, Nan Liu, Lois E.H. Smith
Journal: Journal of Clinical Investigation (2003)

Oxygen administration to immature neonates suppresses VEGF-A expression in the retina, resulting in the catastrophic vessel loss that initiates retinopathy of prematurity. To investigate the mechanisms responsible for survival of blood vessels in the developing retina, we characterized two VEGF-A receptors, VEGF receptor–1 (VEGFR-1, also known as Flt-1) and VEGF receptor–2 (VEGFR-2, also known as Flk-1). Surprisingly, these two VEGF-A receptors differed markedly during normal retinal development in mice. At 5 days postpartum (P5), VEGFR-1 protein was colocalized with retinal vessels, whereas VEGFR-2 was detected only in the neural retina. Real-time RT-PCR identified a 60-fold induction of VEGFR-1 mRNA in retina from P3 (early vascularization) to P26 (fully vascularized), and no significant change in VEGFR-2 mRNA expression. Placental growth factor-1 (PlGF-1), which exclusively binds VEGFR-1, decreased hyperoxia-induced retinal vaso-obliteration from 22.2% to 5.1%, whereas VEGF-E, which exclusively binds VEGFR-2, had no effect on blood vessel survival. Importantly, under the same conditions, PlGF-1 did not increase vasoproliferation during (a) normal vessel growth, (b) revascularization following hyperoxia-induced ischemia, or (c) the vasoproliferative phase, indicating a selective function supporting blood vessel survival. We conclude that VEGFR-1 is critical in maintaining the vasculature of the neonatal retina, and that activation of VEGFR-1 by PlGF-1 is a selective strategy for preventing oxygen-induced retinal ischemia without provoking retinal neovascularization.
Effect of chylomicron remnants on apolipoprotein E synthesis in HepG2 cells
Authors: Tamio Teramoto, Teruhiko Matsushima, Makoto Kinoshita, Tsuyoshi Watanabe, Yoshiaki Hashimoto, Kazuhisa Tsukamoto, Keita Katsuragawa, Satoko Okazaki, Masami Yamanaka
Journal: Metabolism (1994)
Theme issue for patients: Summary of rapid responses
Authors: B. Twisselmann
Journal: BMJ (2003)

EDITOR–The theme issue for patients with its unusual layout and unfamiliar articles resulted in a predictably large number of responses, most from the United Kingdom. They were penned mainly in reaction to Smith's introductory note, From the editor, which offered an analogy between hospitals and supermarket car parks; to the guest editor's comment, and to Hammond's end piece.1–3

Many respondents did not like the layout and design of the issue. Patricia Wilson …
Microvascular involvement in systemic sclerosis: laser Doppler evaluation of reactivity to acetylcholine and sodium nitroprusside by iontophoresis
Authors: L L. Civita, M Rossi, G Vagheggini, F A A Storino, L Credidio, G Pasero, C Giusti, C Ferri
Journal: Annals of the Rheumatic Diseases (1998)

<h3>OBJECTIVES</h3> To investigate the skin vasodilatory response to iontophoretically applied acetylcholine (Ach), an endothelium dependent vasodilator, and to sodium nitroprusside (SNP), an endothelium independent vasodilator, in patients with systemic sclerosis (SSc). <h3>METHODS</h3> Eleven SSc patients were preliminarily studied (10 females, mean age 40.5; mean disease duration 6.5 years), and 16 age and sex matched control subjects. By means of laser Doppler flowmetry skin blood flow was evaluated at third finger, at baseline, and after post-ischaemic hyperaemia test and during iontophoretically transcutaneous application of 1% solution of Ach and SNP. <h3>RESULTS</h3> No significant differences in basal skin blood flow were detected between SSc patients and controls. Cutaneous vasodilatory response to ischaemia, Ach, and SNP was significantly less pronounced in SSc patients compared with controls (p&lt;0.001). Moreover, among SSc patients a lower (p&lt; 0.05) vasodilatory response to Ach compared with ischaemia and SNP was recorded. <h3>CONCLUSIONS</h3> These data confirm a reduction of skin digital vasodilatory reserve in SSc patients and suggest a defect of both endothelial dependent arteriolar relaxation and wall compliance in the pathogenesis of this dysfunction.
Fatal Reactions to Drug Therapy
Authors: Jan Koch-Weser
Journal: New England Journal of Medicine (1974)

During recent hearings of the Senate Health Subcommittee on the "Kennedy Drug Bill" a curious numbers game was played with the ultimate in adverse drug reactions: those that kill the patient. Initially, wide publicity was given to an unsubstantiated estimate of 30,000 deaths resulting from drug therapy each year in the United States. Subsequently, this mythical number was gradually inflated to 140,000 on the basis of misleading extrapolations from two recent surveys on acute medical services.In 1971 the Boston Collaborative Drug Surveillance Program reported that for 27 (0.44 per cent) of 6199 consecutively monitored medical patients in eight teaching . . .