tbuckley/cabot-search huggingface dataset:
Formononetin could increase soluble-APPα secretion by up-regulating ADAM10 level
Authors: Ting Zhou, Miao Shun, Liang Zhou, Huan Yang, Kaiyin Zhong, Ximeng Zhang, Hui Zhang, Dongsheng Fan, Dehua Chui
Journal: Molecular Neurodegeneration (2012)

Background Formononetin, which is used as neuroprotective medicine, was reported to have benefits for Alzheimer’s disease (AD). However, little is known on how Formononetin exerts these beneficial effects. In this study, we investigated the molecular mechanisms through which Formononetin increased soluble-APPa (sAPPa) secretion and thus was neuroprotective in human-APP Swedish mutation cell cultures (N2a-APP cell). Method and results By using N2a-APP cell cultures combined with hypoxia treatment, we confirmed that chronic treatment with Formononetin could have neuroprotective effects, which was followed by reduced and increased Caspase3 activity and cell viability. Strikingly, our data revealed that the Caspase3-blocking effect of Formononetin was largely mediated by stimulation of a-secretase cleavage of APP, resulting in increased secretion of its soluble form, sAPPa. Moreover, the protective effect of Formononetin was totally inhibited by TAPI-2, an a-secretase complex inhibitor, suggesting the role of the sAPPa pathway in the neuroprotective response to Formononetin. Furthermore, we also revealed that the stimulation effect of Formononetin on a-secretase activity was mainly a result of up-regulating ADAM10 expression at the transcriptional level. Conclusion
Hepatitis B and endoscopy.
Authors: A G Morgan, W A McAdam, B E Walker
Journal: BMJ (1978)

primary iron storage disease studied here this patient did demonstrate a very slow-moving iron-binding compound on polyacrylamide gels after incubation with ;9Fe.(3) Our choice of the word "abnormal" was unwise as we meant to indicate that the tumour ferritin was different from hepatic ferritin rather than implying a demonstrated functional abnormality.Unfortunately, further studies could not be carried out on this patient but the presence of the tumour ferritin and secondary siderosis (histologically) seemed to warrant the speculation.
Adjuvant Therapy of Node-Negative Breast Cancer
Authors: William L. McGuire
Journal: New England Journal of Medicine (1989)

Axillary-node–negative breast cancer develops in approximately 70,000 women in the United States each year. Local surgery, radiotherapy, or both lead to long-term survival in the great majority (approximately 70 percent) of such women. Most do not have distant micrometastases and therefore do not require systemic therapy. The four articles on systemic adjuvant therapy in this issue of the Journal 1 2 3 4 are important first steps in the long journey toward the goal of eliminating micrometastases and curing the disease in the women whose cancer will recur. How should these results affect current treatment for node-negative breast cancer in the general population?The . . .
Can<i>Not</i>Smoking Be Hazardous to Your Health?
Authors: Noel S. Weiss
Journal: New England Journal of Medicine (1985)

The case–control study by Lesko et al. in this issue of the Journal 1 is the most recent of several to find that cigarette smoking is less prevalent among postmenopausal women with endometrial carcinoma than among other postmenopausal women. Although the observed association is not strong — an estimated 30 per cent reduction in risk to current smokers — there are several reasons to believe that it indicates a protective effect of smoking in some women. The association has been observed in both population-based and hospital-based studies, and it appears to be strongest in heavy smokers. Furthermore, a negative association between . . .
IMPACT OF IMMEDIATE MULTIVESSEL INTERVENTION ON OUTCOME OF PATIENTS WITH MULTIVESSEL DISEASE UNDERGOING PRIMARY PCI FOR CARDIOGENIC SHOCK IN REAL LIFE
Authors: Uwe Zeymer, Mathias Hochadel, Harald Darius, Johannes Brachmann, K. Hauptmann, Ralf Zahn, Klinikum Ludwigshafen
Journal: Journal of the American College of Cardiology (2013)
The Dangers of Saccharin
Authors: G. G. Liddle
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Your All Saints' Day issue arrived while I was recovering from the Halloween siege of Trick-or-Treats. We had weathered the neighborhood children, with their sickly demands for sweets, and I propped old<i>JAMA</i>in front of my coffee, muttering, "Where were the tricks of yesteryear, oh where, oh where, oh where?" Then I hit old page 571, and there she was! Unknown to myself I had poisoned the entire juvenile community with deadly cyclamate. I had tricked<i>them</i>. I could see them staggering off to school, saccharinated to inferno. You doubt me? Well, see old<i>JAMA</i>(<b>194</b>:571). Grrrr.
Direct demonstration of the human parvovirus in erythroid progenitor cells infected in vitro.
Authors: N Young, M Harrison, J Moore, P Mortimer, R K Humphries
Journal: Journal of Clinical Investigation (1984)

The human parvovirus (HPV), the cause of transient aplastic crisis of hereditary hemolytic anemia, has been shown to be cytotoxic for erythroid progenitor cells and its presence in these cells demonstrated by morphologic techniques. A relatively pure population of progenitors, isolated by removal of immature erythroid bursts from primary culture, was the target of the virus infection. Infected cells failed to proliferate in secondary culture. Using a monoclonal antibody to HPV, specific fluorescence was demonstrated in a minority of cells 24-48 h after infection with virus. Infected cells examined by electron microscopy showed marked toxic ultrastructural alterations and parvovirus-like particles in crystalline arrays in the nucleus.
A CASE OF EPITHELIOMA DEVELOPED ON THE BASIS OF A HEALED LUPUS VULGARIS TREATED BY X-RAYS.
Authors: DAVID LIEBERTHAL
Journal: JAMA (1901)

The patient, a tradesman, a native of Poland, is 53 years old, and does not remember ever having been afflicted with any disease, with the exception of that herein described. His parents, who are dead, enjoyed good health, and neither they nor any other of his relatives were subject to skin affections. He has eight children, and two grandchildren, all enjoying good health. At the age of about 2 years there developed behind his left ear a growth which soon exulcerated, and in the course of a few years his face, especially the nose and mouth, became affected. The skin thus diseased repeatedly broke down and rehealed. The mouth gradually became so closed that he could only insert his little finger. At this stage the nose, which meantime had repeatedly broken and healed, began to break down until its tip was destroyed at about the age of 12 years. He
Health economist cautions against new breast cancer drug
Authors: Lynn Eaton
Journal: BMJ (2005)

Healthcare organisations should not rush into using trastuzumab (Herceptin) for early breast cancer without first examining the implications on budgets of doing so, warns a Belgian health economist.

Mattias Neyt of Ghent University had carried out an economic analysis of the benefits of the new breast cancer treatment. He also says that doctors should wait until the final results of clinical trials are published so that …
TCT-755 Trancatheter Aortic Valve Implantation in Patients with Pure Severe Native Aortic Regurgitation: Results after 3 Year of Follow-Up
Authors: Marco Luciano Rossi, Cristina Barbaro, Paolo Pagnotta, Carla Lucarelli, Gabriele Gasparini, Patrizia Presbitero
Journal: Journal of the American College of Cardiology (2014)
Defective expression and function of natural killer cell–triggering receptors in patients with acute myeloid leukemia
Authors: Régis T. Costello, Simona Sivori, Emanuela Marcenaro, Marina Lafage-Pochitaloff, Marie-Joelle Mozziconacci, Denis Reviron, Jean-Albert Gastaut, Daniela Pende, Daniel Olive, Alessandro Moretta
Journal: Blood (2002)
[160] CLINICAL OUTCOME OF HCV-RELATED GRAFT CIRRHOSIS AND PROGNOSTIC VALUE OF HEPATIC VENOUS PRESSURE GRADIENT
Authors: G. Kalambokis, D. Samonakis, P. Manousou, F. Grille, A.P. Dhillon, D. Patch, K. Rolles, A.K. Burroughs
Journal: Journal of Hepatology (2007)
Electron microscopic and time lapse studies of mitosis in cultured rat hepatocytes
Authors: Carol A. Sattler, Norimasa Sawada, Gerald L. Sattler, Henry C. Pitot
Journal: Hepatology (1988)

Primary cultures of adult rat hepatocytes in a serum-free medium were observed by time lapse cinematography to proceed through mitotis and cytokinesis. An ultrastructural study of these cultures is presented with electron micrographs of each stage of mitosis and cytokinesis. The cultured hepatocytes begin to enter prophase about 48 hr after plating and proceed through mitosis in approximately 70 min not including cytokinesis. During this time, they remain somewhat flattened and joined to neighboring cells rather than rounding up. Both mononucleate and binucleate hepatocytes proceed through mitosis. Some mononucleate cells do not undergo cytokinesis, resulting in the formation of binucleate cells. In binucleate hepatocytes, both nuclei proceed through prophase simultaneously. Usually a single mitotic spindle with a large metaphase plate containing chromosomes from both nuclei is observed. Cytokinesis frequently occurs in binucleate hepatocytes which have a single mitotic spindle. Some binucleate cells form tripolar or 4-polar metaphase plates. In tripolar metaphases, some cells do not divide, resulting in multinucleate cells, whereas others undergo cytokinesis yielding three mononucleate cells or one binucleate and one mononucleate cell. Two mitotic spindles located perpendicularly to each other with microtubules intertwining have been observed in 4-polar metaphases. In this latter case, no cytokinesis has been observed. This study shows that both mononucleate and binucleate adult rat hepatocytes cultured in a serum-free medium in the presence of epidermal growth factor not only synthesize DNA, but progress through mitosis and often cytokinesis.
Clinical range of neonatal rotavirus gastroenteritis.
Authors: J Dearlove, P Latham, B Dearlove, K Pearl, A Thomson, I G Lewis
Journal: BMJ (1983)

A baby admitted to a special care baby unit with profuse watery diarrhoea was found to have a rotavirus infection. A total of 196 babies were admitted to the unit over the next year. Routine stool samples were taken weekly from all babies and additional samples were taken from all babies who developed clinical signs suggesting sepsis. A total of 76 babies excreted rotavirus; 32 of these developed a diarrhoeal illness, 12 of whom were severely ill with bloody diarrhoea and abdominal distension; and two had perforations. The smaller, sicker babies who stayed in hospital longer were more likely to acquire infection; colostrum did not confer protection against rotavirus or symptomatic infection. The outbreak of rotavirus declined independently of the measures taken to eradicate it. Our findings suggest that neonatal rotavirus infection may occasionally cause severe gastrointestinal problems.
THE EFFECT OF ACTH AND CORTISONE ON CEREBRAL BLOOD FLOW AND METABOLISM 1
Authors: Willis Sensenbach, Leonard Madison, Lamar Ochs
Journal: Journal of Clinical Investigation (1953)

Mental aberrations of various types and in vary- ing degree are observed in many patients during the administration of ACTH or cortisone.Most often the changes are those of personality or mood; restlessness, irritability, insomnia, elation, depression, euphoria are among the more common manifestations.Less commonly, but nonetheless, not rarely, frankly psychotic episodes occur.In Cushing's syndrome, where there is an abundance of endogenous adrenal cortical hormones, there is a high incidence of abnormal mentation including hysteria,.suicidal depressive states, simple schizo-' phrenia -and paranoia (1).The production of mental symptoms and psychoses consequent to the administration of ACIH or cortisone and their frequency in Cushing's syndrome suggest the possibility that there is a biochemical basis for certain of the psychoses and personality disorders.This report deals with the study of the cerebral circulation and metabolism before, during, and after the administration of ACTH and cortisone for.thepurpose of determining the cerebral hemo- dynamic and metabolic effects of these hormones and possibly of elucidating the relationship of the physiological derangements to the -induced mental aberrations.H. G. Ulcerative 26 100 58 46 55 1.27 1.39 1.05 74 64 S8 2.61 2.61 3.12 5.22 3.22 S.50 colitis D. L. G. Dermatitis 32 200 53 53 52 1.35 1.39 1.36 72 74 71 4.12 4.00 4.10 5.83 4.77 3.64
Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial
Authors: Martin Ridderstråle, Knut Robert Andersen, Cordula Zeller, Gabriel Kim, Hans J Woerle, Uli C Broedl
Journal: The Lancet Diabetes & Endocrinology (2014)
748-3 The Relationship Between the Location of Ischemic Perfusion Defects on Stress Technetium-99m Sestamibi SPECT Scintigraphy and the Location of a Subsequent Myocardial Infarction
Authors: Gregory L. Miller, Steven D. Herman, Sunil Kalla, Gary V. Heller, William A. Levin, Kira Stillwell, Mark I. Travin
Journal: Journal of the American College of Cardiology (1995)
Abstract 2841: Inducible modulation of NF-kappaB in macrophages reveals that timing of intervention may be critical to therapeutic outcome during mammary tumorigenesis
Authors: Whitney Barham, Linda Connelly, Halina M. Onishko, Lianyi Chen, Taylor Sherrill, Tahera Zabuawala, Michael Ostrowski, Timothy Blackwell, Fiona Yull
Journal: Cancer Research (2011)

Abstract Elevated levels of NF-kappaB signaling are associated with multiple cancers. Therefore, it is not surprising that inhibitors of NF-kappaB are being investigated as potential therapeutics. While extensive efforts are being made to identify inhibitors there is less focus on investigating the effects of inhibition in specific cell types and during defined stages of tumor progression. We have developed murine transgenic models that enable us to induce expression of an activator or inhibitor of NF-kappaB in macrophages, by adding doxycycline to the drinking water of mice. We have combined these with the Polyoma model of mammary cancer to investigate the effects of modulation of NF-kappaB signaling specifically within macrophages. Given several recent publications we were predicting that activation of NF-kappaB would have pro-tumor effects. However, using a tail vein injection model, our data identifies a stage during progression in which activation of NF-kappaB in macrophages significantly limits metastasis. Activation of NF-kappaB alters immune cell populations and results in rapid killing of tumor cells during the seeding phase. In this model inhibition of NF-kappaB in macrophages during this critical stage of metastasis is pro-tumor. This suggests that while inhibition of NF-kappaB at later stages of tumor progression may have therapeutic benefit, inhibition during the seeding phase my lead to the opposite effect. Our studies highlight the importance of continued investigation into aspects of cell specificity and timing that may change the potential outcome of a clinical trial using NF-kappaB inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2841. doi:10.1158/1538-7445.AM2011-2841
A Hospital in a Disaster Area
Authors: Don Val Langston
Journal: JAMA (1964)

AT 5:36 PM, March 27, 1964, an earthquake of severe proportion struck south central Alaska, including the city of Anchorage. This quake, with its epicenter approximately 75 miles from Anchorage, was the largest ever recorded in North America. It struck at the most heavily populated area of the state, and dealt a harsh blow to the young state's economy. Providence Hospital, with 155 beds, is the largest civilian general hospital in Alaska. There are four other hospitals in Anchorage: Presbyterian, which was immediately evacuated after the quake because of its proximity to a fault; the US Air Force 5040th Hospital, evacuated immediately because of structural damage; the Alaska Psychiatric Institute, which continued to function in its usual role, and cared for patients from the institution at Valdez; and the Alaska Native Service Hospital, run by the US Public Health Service. This latter continued operation following the earthquake, and was instrumental
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
Authors: Manja Meggendorfer, Andreas Roller, Torsten Haferlach, Christiane Eder, Frank Dicker, Vera Grossmann, Alexander Kohlmann, Tamara Alpermann, Kenichi Yoshida, Seishi Ogawa, H. Phillip Koeffler, Wolfgang Kern, Claudia Haferlach, Susanne Schnittger
Journal: Blood (2012)
High serum uric acid level and low urine pH as predictors of metabolic syndrome: a retrospective cohort study in a Japanese urban population
Authors: Shigeko Hara, Hiroshi Tsuji, Yuki Ohmoto, Kazuhisa Amakawa, Shiun Dong Hsieh, Yasuji Arase, Hiromu Nakajima
Journal: Metabolism (2011)
Hypertrichosis due to porphyria cutanea tarda associated with blastic transformation of myelofibrosis
Authors: W.Y. Au, S.C.F. Tam, K.M. Ho, Y.L. Kwong
Journal: British Journal of Dermatology (1999)

Journal Article Hypertrichosis due to porphyria cutanea tarda associated with blastic transformation of myelofibrosis Get access W.Y. Au, W.Y. Au University Department of Medicine, Departments of *Biochemistry and †Dermatology, Queen Mary Hospital, Pokfulam Road, Hong Kong E‐mail: ylkwong@hkucc.hku.hk Search for other works by this author on: Oxford Academic Google Scholar S.C.F. Tam, S.C.F. Tam University Department of Medicine, Departments of *Biochemistry and †Dermatology, Queen Mary Hospital, Pokfulam Road, Hong Kong E‐mail: ylkwong@hkucc.hku.hk Search for other works by this author on: Oxford Academic Google Scholar K.M. Ho, K.M. Ho University Department of Medicine, Departments of *Biochemistry and †Dermatology, Queen Mary Hospital, Pokfulam Road, Hong Kong E‐mail: ylkwong@hkucc.hku.hk Search for other works by this author on: Oxford Academic Google Scholar Y.L. Kwong Y.L. Kwong University Department of Medicine, Departments of *Biochemistry and †Dermatology, Queen Mary Hospital, Pokfulam Road, Hong Kong E‐mail: ylkwong@hkucc.hku.hk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 5, 1 November 1999, Page 932, https://doi.org/10.1046/j.1365-2133.1999.03175.x Published: 01 November 1999
Abstract 2106: The role of KSRP in non-small cell lung cancer
Authors: Lora A. Wilson, Robert A. Winn
Journal: Cancer Research (2011)

Abstract Precedent has established the role of the Wnt/β-catenin pathway in oncogenesis. Several members of the Wnt family are known to be tumor promoting in non-small cell lung cancer, NSCLC. In this pathway β-catenin, a downstream component, accumulates and serves as a T-cell transcription /lymphoid enhancer factor. We previously identified the Wnt ligand in the lung, Wnt 7a, as a member of the non-canonical pathway/ β-catenin independent pathway, which inhibits transformed cell growth. Currently, we hypothesize that the regulatory protein, KSRP, holds a switch between the canonical and non-canonical pathway. K-homology splicing regulatory protein (KSRP) is a member of the family of AU rich element binding proteins. It possesses four K-homology motifs and causes decay of specific mRNA transcripts in different cell types. In mouse F9 teratocarcinoma cells KSRP negatively regulates β-catenin. The role of KSRP in the non-canonical Wnt pathway in the lung has previously been unknown. Using NSCLC cell lines and nontransformed lung cells we show a correlation between Wnt 7a expression and a positive regulation of KSRP. KSRP expression is elevated in nontransformed cells and alternatively, lower levels of KSRP expression in NSCLC. Over expression of KSRP in NSCLC cells decreases cell proliferation in MTS assay as well as reducing colony formation in clonogenic assays. The silencing of KSRP in nontransformed cells results in an increase in cell proliferation. The positive regulation of KSRP by Wnt 7a positively regulates this mRNA regulatory protein in the noncanonical Wnt pathway as an important factor in tumor suppression. The canonical pathway negatively regulates KSRP, which allows the stabilization of β-catenin mRNA thereby promoting progression of the tumor-promoting pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2106. doi:10.1158/1538-7445.AM2011-2106
A hemispheric asymmetry in somatosensory processing
Authors: Giuseppe Vallar
Journal: Behavioral and Brain Sciences (2007)

Abstract The model presented in the target article includes feature processing and higher representations. I argue, based on neuropsychological evidence, that spatial representations are also involved in perceptual awareness of somatosensory events. Second, there is an asymmetry, with a right-hemisphere–based bilateral representation of the body. Third, the specific aspect of bodily awareness concerning motor function monitoring involves a network that includes the premotor cortex.
Abstract 2234: Combined analysis of TERT, EGFR and IDH status define distinct prognostic classes of GBM
Authors: Marianne Labussiere, Blandine Boisselier, Karima Mokhtari, Anais Rahimian, Olivier Saulnier, Yannick Marie, Marc Sanson
Journal: Cancer Research (2014)

Abstract Background. The importance of telomerase reverse transcriptase (TERT) in gliomagenesis has been recently strengthened by the frequent occurrence of TERT promoter mutations in glioblastomas. Methods. We sequenced TERT promoter mutation in 395 glioblastomas DNA and confronted the results with histology, genetic profile (IDH1 mutation, EGFR amplification, CDKN2A homozygous deletion, loss of chromosome 9 and 10, TP53 mutation), and overall survival (OS). Results. TERT promoter mutations (TERTp-mut) were found in 299/395 glioblastomas (75.7%) and were associated with an older age (median 59.6 vs. 53.6 years p&amp;lt;0.0001). TERTp-mut was an independent factor of poor prognosis (OS= 13.8 months vs. 18.4 months), in both IDH mutated (OS= 13.8 months vs. 37.6., p= 0.022) and IDH wild type (IDH-wt) GBM (OS= 13.7 vs. 17.5 months, p= 0.006). TERTp-mut was associated with IDH-wt and EGFR amplification (EGFR-amp) status. In TERTp-wt group, OS was twice longer in EGFR wt compared to EGFR-amp GBM (OS= 26.6 months vs. 13.3 months; p= 0.005). In the EGFR-wt group, TERTp-wt patients had a much better outcome (OS= 26.3 vs. 12.5 months; p&amp;lt; 0.0001), whereas in the EGFR-amp group, TERTp-mut patients did better (OS = 15.8 vs. 13.3 months; p= 0.05). Taken together the absence of both EGFR-amp and Tertp-mut is associated with better survival (26.5 months for IDH-wt, 36.7 months for IDH-mut patients). Conclusions. The analysis of TERT promoter mutations, in combination with EGFR amplification and IDH mutation status, refines the prognostic classification of GBM. Citation Format: Marianne Labussiere, Blandine Boisselier, Karima Mokhtari, Anais Rahimian, Olivier Saulnier, Yannick Marie, Marc Sanson. Combined analysis of TERT, EGFR and IDH status define distinct prognostic classes of GBM. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2234. doi:10.1158/1538-7445.AM2014-2234