Cardiac Arrest and Myocardial Infarction Immediately after Sumatriptan Injection
Authors: Michael L. Main
Journal: Annals of Internal Medicine (1998)

Letters15 May 1998Cardiac Arrest and Myocardial Infarction Immediately after Sumatriptan InjectionMichael L. Main, MD, Karthik Ramaswamy, MD, and Thomas C. Andrews, MDMichael L. Main, MDUniversity of Texas Southwestern Medical Center at Dallas; Dallas, TX 75235, Karthik Ramaswamy, MDUniversity of Texas Southwestern Medical Center at Dallas; Dallas, TX 75235, and Thomas C. Andrews, MDUniversity of Texas Southwestern Medical Center at Dallas; Dallas, TX 75235Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-10-199805150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Sumatriptan is a selective 5-hydroxytryptamine agonist efficacious in the treatment of migraine headache. Although chest discomfort associated with use of this product is common, cardiovascular complications are rare. We describe a woman who had cardiac arrest and a right ventricular myocardial infarction immediately after subcutaneous injection of sumatriptan.A 48-year-old surgically postmenopausal woman with a history of type 2 diabetes mellitus and tobacco abuse presented to our ambulatory care clinic with a migraine headache. She was given 6 mg of sumatriptan subcutaneously and within 10 minutes had chest tightness and nausea that persisted despite administration of meperidine ...References1. MacIntyre PD, Bhargava B, Hogg KJ, Gemmill JD, Hillis WS. Effect of subcutaneous sumatriptan, a selective 5HT1 agonist on the systemic, pulmonary, and coronary circulation. Circulation. 1993; 87:401-5. Google Scholar2. Mueller L, Gallagher M, Ciervo CA. Vasospasm-induced myocardial infarction with sumatriptan. Headache. 1996; 36:329-31. Google Scholar3. O'Conner P, Gladstone P. Oral sumatriptan-associated transmural myocardial infarction. Neurology. 1995; 45:2274-6. Google Scholar4. Kelly KM. Cardiac arrest following use of sumatriptan. Neurology. 1995; 45:1211-3. Google Scholar5. Ottervanger JP, Paalman HJ, Boxma GL, Stricker BH. Transmural myocardial infarction with sumatriptan. Lancet. 1993; 341:861-2. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Southwestern Medical Center at Dallas; Dallas, TX 75235 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByVasospasm induced myocardial ischaemia secondary to sumatriptan useTriptans for Migraine Patients With Vascular Risks: New Insights, New OptionsToxin-Induced Cardiovascular FailureSumatriptan therapy for headache and acute myocardial infarctionTriptans and troponin: a case reportTreatment Choices and Patterns in Migraine Patients With and Without a Cardiovascular Risk ProfileThe TriptansRenal Infarction During the Use of Rizatriptan and Zolmitriptan: Two Case ReportsCoronary Vasospasm and Myocardial Infarction Induced by Oral SumatriptanCardiovascular Tolerability and Safety of Triptans: A Review of Clinical DataOral Sumatriptan‐Induced Myocardial InfarctionTriptan Use Preceding Life-Threatening Arrhythmias in Charcot–Marie–ToothComparison of contractile responses to donitriptan and sumatriptan in the human middle meningeal and coronary arteriesAdvances in pharmacological treatment of migrainePharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vesselsTolerability of sumatriptan: clinical trials and post-marketing experienceSumatriptan-Associated Mesenteric IschemiaJulia J. Liu, MD, David J. Brandhagen, MD, and Joseph C. Ardolf, MDSpinal Cord Infarction During Use of Zolmitriptan: A Case ReportHuman Isolated Coronary Artery Contraction To Sumatriptan: A Post Hoc AnalysisAcute management of migraine: triptans and beyondSumatriptan 15 May 1998Volume 128, Issue 10Page: 874KeywordsAngiographyCoronary arteriesElectrocardiographyHeartMyocardial infarctionNecrosisStable coronary artery diseaseSubcutaneous injectionsThoraxVasoconstriction Issue Published: 15 May 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...