tbuckley/cabot-search huggingface dataset:
Risk Factors and Prevalence of Coronary Heart Disease in Puerto Rico
Authors: MARIO R. GARCÍA-PALMIERI, RAÚL COSTAS, MERCEDES CRUZ-VIDAL, MARCELINO CORTÉS-ALICEA, ANGEL A. COLÓN, MANUEL FELIBERTI, ANGEL M. AYALA, DOLORES PATTERNE, RAFAEL SOBRINO, RAQUEL TORRES, EMILIO NAZARIO
Journal: Circulation (1970)

In spite of an apparently increasing mortality rate from coronary heart disease in Puerto Rico, the age-specific mortality rate from this illness is considerably lower in the island than in the U. S. mainland. Examination of 9,814 Puerto Rican urban and rural men in the 45 to 64-year age group revealed sizable and statistically significant differences in monthly income, cigarette smoking, ingestion of fats, blood pressure, heart rate, relative weight, serum cholesterol, serum glycerides, prevalence of diabetes, and prevalence of hypertension (lower in rural dwellers), and also in vital capacity, consumption of calories per unit body weight, and physical activity (higher in rural area). No urban-rural difference in coronary heart disease prevalence was found, but the prevalence of definite myocardial infarction, established on basis of electrocardiographic criteria alone, was significantly higher in the 45 to 54-year urban group. Follow-up of this population to study incidence of disease and the influence of the various factors upon the development of disease is being conducted.
Israel bans imports of fertilised ova
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2001)

Starting 1 October, infertile Israelis who want to be parents will no longer be able to import frozen fertilised ova from any foreign country, because the health ministry fears that they might be contaminated with infectious diseases.

Ministry legal adviser Mira Huebner and ministry adviser and gynaecologist Dr Mordechai Halperin said that in vitro fertilisation procedures abroad may not be safe and women receiving implanted embryos could be infected with HIV, hepatitis B or C, or other diseases.

Because of the severe shortage of donor eggs …
The Influence of Residual Nor-β-CFT in 11C CFT Injection on the Parkinson Disease Diagnosis
Authors: Tingting Huang, Hongliang Wang, Ganghua Tang, Xiang Liang, Xinchong Shi, Xiangsong Zhang
Journal: Clinical Nuclear Medicine (2012)

Fully automated synthesis of 11C-labeled 2β-carbomethoxy-3β-(4-fluorophenyl)tropane (11C CFT) as a dopamine transporter positron emission tomography (PET) tracer is performed with Sep-Pak purification, which cannot separate 11C CFT from nor-β-CFT and will result in the residual precursor nor-β-CFT in the final 11C CFT injection. The aim of this study is to estimate the influence of the residual precursor nor-β-CFT in the 11C CFT injection on the Parkinson disease (PD) diagnosis results.Automated synthesis of 11C CFT was performed using the different chemical amounts (0.10, 0.20, 0.25, and 0.30 mg) of nor-β-CFT with Sep-Pak purification. According to the given different amounts of nor-β-CFT in the radiosynthesis, clinically suspected 25 PD patients were randomly divided into the following 4 groups: 0.10 mg, 0.20 mg, 0.25 mg, and 0.30 mg, which had 5, 9, 5, and 6 cases, respectively. A normal control group with 0.10 mg of nor-β-CFT included 2 volunteers. After the brain PET images of the subjects were acquired, the regions of interests of striatum and cerebellum were drawn, and the standard uptake values of these regions were calculated. Finally, comparing the 18F FDG PET and clinical diagnosis, the coincidence rates of 11C CFT PET imaging for PD patients were determined.Given 0.25 mg of the precursor nor-β-CFT, high radiochemical yield (59.4%) and high radiochemical purity of 11C CFT were obtained using Sep-Pak purification within a short synthesis time. The 11C CFT standard uptake value ratios of striatum to cerebellum had no statistically significant difference (P > 0.05) between the 4 suspected PD groups. However, there was statistically significant difference (P < 0.05) between the suspected PD groups and the control group. Also, the coincidence rates between the PD diagnosis using 11C CFT PET imaging for different dose groups and the final clinical diagnosis result were greater than 80%, but difference between the coincidence rates was not statistically significant (P = 0.955).A simple, rapid, and efficient automated synthesis of 11C CFT using 0.25 mg of nor-β-CFT with Sep-Pak purification is afforded, providing enough radioactivity for PD PET imaging routinely. The residual nor-β-CFT in the 11C CFT injection is not inhibit 11C CFT binding to dopamine transporter, and also has no influence on PET diagnosis results of PD.
THE PRESENT-DAY MANAGEMENT OF STONE IN THE KIDNEY
Authors: CHARLES PIERRE MATHÉ
Journal: JAMA (1931)

Stone has received more attention than any other lesion of the kidney; however, certain conservative methods are retained which often result in the destruction of the kidney harboring the stone, and certain benign operations are continued which, in spite of being popularized for their simplicity and safety, favor the recurrence of stone. This paper reviews seventy-four cases of renal calculi removed by surgical intervention or cystoscopic maneuvers. Silent, quiescent, nonobstructing calculi unaccompanied by infection were untreated and are not included. The etiologic role of congenital deformity, stasis and infection is carefully studied and correction emphasized. The pathologic effects of stone, pyelonephritis, ulcerative necrosis, renal abscess, perinephric abscess and hydronephrosis are thoughtfully considered. These pathologic processes progressively destroy the kidney and emphasize the necessity of early recognition and removal of stone. Several cases presenting the so-called nonsurgical coralform type of stone are reported in which fragments broke off and passed into
Implementing a Survivorship Care Plan for Patients With Breast Cancer
Authors: Patricia A. Ganz, Erin E. Hahn
Journal: Journal of Clinical Oncology (2008)

Breast cancer survivors account for 23% of the more than 10 million cancer survivors in the United States today. The treatments for breast cancer are complex and extend over a long period of time. The post-treatment period is characterized by gradual recovery from many adverse effects from treatment; however, many symptoms and problems persist as late effects (eg, infertility, menopausal symptoms, fatigue), and there may be less frequent long-term effects (eg, second cancers, lymphedema, osteoporosis). There is increasing recognition of the need to summarize the patient's course of treatment into a formal document, called the cancer treatment summary, that also includes recommendations for subsequent cancer surveillance, management of late effects, and strategies for health promotion. This article provides guidance on how oncologists can implement a cancer treatment summary and survivorship care plan for breast cancer survivors, with examples and linkage to useful resources. Providing the breast cancer treatment summary and survivorship care plan is being recognized as a key component of coordination of care that will foster the delivery of high-quality cancer care.
Anorexia nervosa in Twins
Authors: W. Vandereycken, R. Pierloot
Journal: Psychotherapy and Psychosomatics (1981)

In 1979, Askevold and Heiberg made an interesting contribution to the discussion on the hereditability of anorexia nervosa by reviewing a series of case reports concerning monozygotic twins. Their data, however, were not entirely accurate and they also overlooked some important references which are briefly discussed. 3 cases of the authors' own practice are added. A final examination of the available data with respect to anorexia nervosa in twins does not substantially support the assumption that genetic factors may play a determining role in the etiology of this syndrome.
Hereditary Obesity: Relation to Serum Lipoproteins and Protein Concentrations in Swine
Authors: LENA A. LEWIS, IRVINE H. PAGE
Journal: Circulation (1956)

The importance of heredity in determining the cholesterol, lipoprotein, and plasma protein levels has received insufficient attention. All of these have a greater concentration in the blood of short-fat (mesomorphic), castrate, male, miniature pigs than in long-lean (ectomorphic) animals. These differences seem to persist even when weight changes and growth are rapid. We believe that some of the wide variability of blood lipid levels in human beings is due to genetic factors in the heterogeneous human population on varied diets.
TCT-298 Six-month Intravascular Ultrasound Analysis of the DESolve FIM Trial with a Novel PLLA-based Fully Biodegradable Drug-eluting Scaffold
Authors: Jose Costa, John Ormiston, Alexandre Abizaid, James Stewart, Daniel Chamié, Mark Webster, John Yan, Vinayak Baht, Lynn Morrison, Sara Toyloy, Stefan Verheye
Journal: Journal of the American College of Cardiology (2012)
GPs save 400m in 2008 by increasing use of generic drugs
Authors: R. Coombes
Journal: BMJ (2009)

GPs in England who switched prescribing habits to cheaper generic drugs made almost double the anticipated savings last year, with the largest gains made on statins.

Calculations by Keele University for the National Audit Office show that £394m (€450m; $600m) was saved through more cost effective prescribing in 2008. In 2007 the audit office reported that primary care trusts could save more than £200m a year if GPs increased the use …
Full-time Pregnancy Associated with Hydatidiform Mole
Authors: E. M. Rose
Journal: BMJ (1952)

temperature by a similar thermocouple attached to the great toe of one foot, and the calf blood flow-representing muscle flow-by a thermostatically controlled water plethysmograph ( Barcroft and Edholm, 1943) applied to the same or the contralateral leg.The chart is typical, and shows that the skin temperature and the calf blood flow both begin to increase as soon as anaesthesia is induced, and there is a corresponding fall in the rectal temperature.MLS/ MIN/IOOGAMS.TISSUE 10 6-| .; ' CALF FLOW (RT) 4 - I_ 0. RECTAL TEt TEtMP TEMP 38, 34T\OE TEMPERATURE (RT) ..
Bone Mineral Density (BMD) Changes at 1 Year in Postmenopausal Women Who Are Not Receiving Adjuvant Endocrine Therapy for Breast Cancer (BCA).
Authors: C. Van Poznak, P. Morris, G. D'Andrea, A. Schott, J. Griggs, M. Fornier, J. Smerage, N. Henry, A. Hurria, P. Drullinsky, N. Mills, D. Hayes, C. Hudis
Journal: Cancer Research (2009)

Abstract Background: Adjuvant therapy for breast cancer (BCA) may be associated with an increased risk for osteoporosis. This prospective, observational study evaluates BMD changes in postmenopausal women undergoing adjuvant chemotherapy (CTX) for early stage BCA, in the absence of endocrine therapy.Methods: Women who have been postmenopausal for at least 5 years, and who were recently diagnosed with Stage 0-III BCA were eligible to undergo serial BMD if adjuvant endocrine therapy was not recommended. Study BMDs were performed at baseline, 1 and 2 years. All patients (pts) were counseled on calcium, vitamin D and weight bearing exercise. This study was designed to assess serial changes in BMD in the individual and to compare changes in those treated with CTX to those who received no systemic therapy (observation). The study was closed prior to reaching target sample size due to slow accrual.Results: Sixteen pts enrolled. Eleven pts received CTX with a dose dense anthracycline and taxane containing regimen and 5 pts received no systemic adjuvant therapy. Twelve pts, median age 63 (range 52-80), have completed the 1 year assessment and are reported here. Two pts treated with CTX and 1 pt on observation were on bisphosphonates at study entry. Baseline BMD mean in gm/cm2 at the lumbar spine (LS) was 1.112 (range 0.807-1.389) and total hip (TH) was 0.989 (range 0.760-1.213). At 1 year, mean BMD at LS was 1.078 (range 0.767-1.347) and TH was 0.956 (range 0.753-1.210). For all 12 pts at 1 year, the individual BMD changes in LS &amp; TH BMD ranged from 10% loss to 2% gain, with 8 of the 9 CTX treated pts losing 1-10% of BMD and the 3 pts on observation staying within 2% of baseline. The mean dosage of dexamethasone used during CTX by the 9 CTX pts was 230 mg (range 156-288mg). The 3 observation pts had no exposure to steroids during the parallel time period.Conclusions: This prospective, observational study supports the hypothesis that adjuvant CTX, and/or its supportive medications, may be associated with acute changes in BMD in postmenopausal women. Patient follow up continues.Funded by Susan G. Komen for the Cure POP0402593 Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 1066.
Psychopharmacologic Treatment of Generalized Anxiety Disorder and the Risk of Major Depression
Authors: Renée D. Goodwin, Jack M. Gorman
Journal: American Journal of Psychiatry (2002)

The authors sought to determine the association between treatment for generalized anxiety disorder and the risk of major depression among adults in the community.Data were drawn from the National Comorbidity Survey (N=8,098), a representative sample of the United States population age 15-54. Cox proportional hazards were used to determine the association between specific forms of treatment for generalized anxiety disorder and the risk of major depression.Psychopharmacologic treatment of generalized anxiety disorder was associated with a significantly lower risk of major depression. There was no significant association between either having seen a mental health professional for generalized anxiety disorder or having been prescribed a medication for generalized anxiety disorder and the risk of depression.These results suggest an association between treatment for generalized anxiety disorder and lower risk of depression, which appears specific to pharmacologic treatment. Future research that leads to a more precise delineation of the underlying mechanism of the observed association is needed to identify and develop effective strategies to prevent onset of depression.
Olfaction in Drosophila: from odor to behavior
Authors: John R. Carlson
Journal: Trends in Genetics (1996)

Odors elicit a variety of behavioral responses from Drosophila via a relatively simple, but sensitive, olfactory system. An increasing number of mutants have been found to be defective in olfactory function. Genetic and molecular analyses of the Drosophila olfactory system have identified some of its molecular components, and have revealed some principles of its function and organization.
Artificial Feeding in Acute Melancholia
Authors: J. Neil
Journal: BMJ (1894)

THEIR STULTIFICATION.But after all this trouble had been taken, a discovery was made, by Surgeon-Major Milward, of a fact that nullifies any precautions that have hitlherto been taken.He happened to notiee a inan carrying a large chattie or earthen vessel on his head going past thle Station Hospital, in the direction of the dairy.Surgeon-Major Milward followed the man into the dairy, and found that the chattie was full of milk.On in- quiry it turned out that the dairyman was in the habit of supplementing the deficient supply yielded by his own cows by buffalos milk brought from the bazaar.He says that
Hemoglobin predicts long-term survival in dialysis patients: A 15-year single-center longitudinal study and a correlation trend between prealbumin and hemoglobin
Authors: Morrell Michael Avram, Daniel Blaustein, Paul A. Fein, Naveen Goel, Jyotiprakas Chattopadhyay, Neal Mittman
Journal: Kidney International (2003)
Patient Flow with Coronary Artery Diagnosis and Therapy.
Authors: H. L. Christensen
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Patient Flow with Coronary Artery Diagnosis and Therapy.H. L. Christensen, M.D., A. Susmano, M.D., R. C. Carleton, M.D., F.A.C.P.H. L. Christensen, M.D.Search for more papers by this author, A. Susmano, M.D.Search for more papers by this author, R. C. Carleton, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-862_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCoronary arteriography and saphenous-vein-bypass graft are a diagnosic-therapeutic sequence. This report concerns events that punctuate this sequence. Two groups (1970, 1971) of 100 consecutive patients each (153 men, 47 women; age 24 to 70 years; 77% in fifth to sixth decades) were the starting point. Each patient was. evaluated clinically before arteriography: 143 were judged to have angina pectoris, 87 with and 56 without prior myocardial infarction; nine had no angina pectoris after myocardial infarction; 48 were judged to have noncardiac pain. Each had biplane coronary arteriography. One patient died, and four had a myocardial infarction as a result of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIndole 1 May 1972Volume 76, Issue 5Page: 862-862KeywordsAnginaAngiographyCoronary arteriesMyocardial infarctionStable coronary artery disease Issue Published: 1 May 1972 PDF DownloadLoading ...
Changes of plasma hemostatic markers during percutaneous transluminal coronary angioplasty in patients with chronic coronary artery disease
Authors: Yasuhiro Saito, Hideo Wada, Miho Yamamuro, Akiko Inoue, Minori Shimura, Kazuyo Hiyoyama, Esteban C. Gabazza, Naoki Isaka, Hiroshi Shiku, Hiroyuki Takeya, Koji Suzuki, Kousuke Kumeda, Hisao Kato, Takeshi Nakano
Journal: American Journal of Hematology (1999)

Changes of hemostatic parameters during percutaneous transluminal coronary angioplasty (PTCA) in 75 patients with chronic coronary artery disease were evaluated. Plasma levels of D-dimer, soluble fibrin monomer, plasmin-α2 antiplasmin inhibitor complex, and tissue factor (TF) were significantly increased in all patients with chronic coronary artery disease. The activity of antithrombin and protein C and the levels of protein C antigen were significantly decreased 1 hr after PTCA, but they returned to normal range 1 day after PTCA. There was no significant difference in the level of plasma APC-PCI complex before and 1 hr after PTCA. The plasma levels of D-dimer, soluble fibrin monomer, thrombomodulin, TF and PPIC were significantly decreased 1 hr, and the plasma levels of plasmin-α2 antiplasmin inhibitor complex 1 day after PTCA. These findings suggest that the decrease of protein C and antithrombin resulted in activation of the coagulation system. One hour after PTCA, the plasma levels of (total-free) TF pathway inhibitor (TFPI) were significantly decreased, but the plasma levels of total and free-TFPI were significantly increased, suggesting that comsumption of (total-free) TFPI occurs during PTCA. Overall, these findings suggest that the hypercoagulable state improves during PTCA and that transient decrease of antithrombin, protein C, (total-free) TFPI or plasmin-α2 antiplasmin inhibitor complex may cause restenosis of coronary artery. Am. J. Hematol. 61:238–242, 1999. © 1999 Wiley-Liss, Inc.
Tumor Size Improves the Accuracy of TNM Predictions in Patients with Renal Cancer
Authors: Pierre I. Karakiewicz, Daniel J Lewinshtein, Felix K.-H. Chun, Alberto Briganti, Francois Guille, Paul Perrotte, Bernard Lobel, Vincenzo Ficarra, Walter Artibani, Luca Cindolo, Jacques Tostain, Clement-Claude Abbou, Dominique Chopin, Alexandre De La Taille, Jean-Jacques Patard
Journal: European Urology (2006)
INJURIES TO THE ANTERIOR VAGINAL WALL IN LABOR.THEIR PRIMARY, INTERMEDIATE AND SECONDARY REPAIR.
Authors: B. C. HIRST
Journal: JAMA (1904)

There is no dispute as to the desirability of repairing the pelvic floor, posterior vaginal wall and perineum in the puerperium, although there is ample room for improvement in the manner of doing it in general practice. The old custom of immediate repair, even before the placenta is expressed, as one authority recommends, must be unlearned. The necessity for as careful a preliminary vaginal examination as any expert gynecic surgeon would make before attempting a secondary repair must be appreciated and the operation itself must be conducted like any other vaginal operation with a good table, proper implements and sufficient assistance if women are to be spared the secondary operations to which thousands of them are now subjected. It has been demonstrated by ample clinical experience that the cervix may be repaired with perfect success and with entire safety to the patient during puerperal convalescence, not only in well-appointed hospitals
Na-K-2Cl cotransporter gene expression and function during enterocyte differentiation. Modulation of Cl- secretory capacity by butyrate.
Authors: J B Matthews, I Hassan, S Meng, S Y Archer, B J Hrnjez, R A Hodin
Journal: Journal of Clinical Investigation (1998)

The basolateral Na-K-2Cl cotransporter (NKCC1) is a key component of the intestinal crypt cell secretory apparatus. Its fate during the transition to absorptive enterocyte and the potential impact of its altered expression on secretory output have not been addressed. In this report, NKCC1 mRNA was found to be expressed in rat jejunal crypt but not villus cells. Butyrate treatment of intestinal epithelial HT29 cells induced a differentiation pattern that recapitulated the rat intestinal crypt-villus axis, with NKCC1 mRNA levels decreasing in a time- and dose-dependent fashion in parallel with upregulation of apical brush-border markers. Butyrate but not acetate or proprionate decreased basal and cAMP-stimulated bumetanide-sensitive K+ (86Rb) uptake in both HT29 cells and the Cl--secreting T84 line. Butyrate markedly decreased transepithelial Cl- secretion in confluent T84 monolayers without effect on cAMP-regulated apical Cl- efflux. We conclude that NKCC1 regulation during enterocyte differentiation occurs at the level of gene expression, and that selective downregulation of NKCC1 gene expression and function by butyrate leads to a profound decrease in transepithelial Cl- secretion. These data emphasize the importance of NKCC1 in determining epithelial secretory capacity and suggest the possibility of modulation of the enterocytic transport phenotype as therapy for diarrheal disorders.
DRAINAGE OF A SYRINGOMYELIC CAVITY, TWICE IN THE SAME PATIENT, THREE YEARS INTERVENING
Authors: Charles H. Frazier
Journal: JAMA (1933)

In these columns almost three years ago, I<sup>1</sup>recorded my experience and the immediate results in the treatment of a syringomyelic cavity by drainage. The operation was performed, April 14, 1930. The cord was exposed by removal of the spinous processes and laminae of the seventh cervical and the first thoracic vertebra. The cavity was drained by an incision just to the right of the median line and, to prevent the lips of the incision uniting, a small strip of gutta percha was interposed. While the patient was seriously crippled, the principal indication for the operation was urinary incontinence. The subsequent history of this case has so many points of interest that I venture to submit it for publication. In the first place, there has been no recurrence of the incontinence for the relief of which the operation was performed. This, of course, was a source of great satisfaction
A Case of Diabetes Insipidus Treated by Ingestion of Suprarenal Glands
Authors: W. F. Clark
Journal: BMJ (1895)

as to surroundings, diet, and nursing since 1891, we may fairly ascribe the great improvement which took place under treat- ment in her general health and condition, an improvement hardly sufficiently indicated by the rise in the number of bhemocytes, to the administration of bone marrow.Small doses of liquor arsenicalis were ordered comparatively early in the treatment of the case, but after a single dose the patient complained of severe gastralgia, and positively refused to take any more of the medicine or any food in which she sus- pected it might have been placed.Arsenic was afterwards administered in the form of pills resembling in appearance the Blaud's pills she was taking, and no inconvenience was complained of.In conclusion I have to thank Dr.