TOLERANCE AND TOXICITY OF INSULIN
Authors: FREDERICK M. ALLEN
Journal: Annals of Internal Medicine (1939)

Article1 February 1939TOLERANCE AND TOXICITY OF INSULINII. WITH FORCED ADMINISTRATION OF CARBOHYDRATE*FREDERICK M. ALLENFREDERICK M. ALLENSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-8-1263 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen insufficient carbohydrate is eaten to protect against insulin, there is naturally a recourse to forced administration of glucose either by stomach or parenterally. In dealing with large doses it is necessary to take account of the toxicity of glucose, though there seems to be no positive information as to whether the injury is entirely physical (osmotic) or whether there is an additional chemical action.GLUCOSE CONTROLSThe writer (1913) published the first experiments with prolonged administration of various sugars by various channels, with a view to the diabetogenic influence and also other possible effects of chronic hyperglycemia. Regarding the...References1. ALLEN FM: Studies concerning glycosuria and diabetes, 1913. Google Scholar2. GIGON A: Ztschr. gesammt. exper. Med., 1924, xl, 1-12; Ztschr. klin. Med., 1924-25, ci, 17-37. Google Scholar3. BOUCKAERTDE NAYERVAN OSTVELDT JPPPM: Compt. rend. Soc. biol., 1934, cxvii, 91-93. Google Scholar4. BOUCKAERTDE NAYERDESMANET JPPPJL: Ibid., 94-96. Google Scholar5. MAZZOLATORREY VPMA: Am. Jr. Obst. and Gynec., 1933, xxv, 643-653. CrossrefGoogle Scholar6. BUTSCH WL: Am. Jr. Physiol., 1934, cviii, 639-642. CrossrefGoogle Scholar7. JACOBSCOLWELL HRAR: Am. Jr. Physiol., 1936, cxvi, 194-200. CrossrefGoogle Scholar8. DOMÉNECH-ALSINA F: Rev. de cir. de Barcelona, 1932, iv, 369-383. Google Scholar9. GILMAN A: Am. Jr. Physiol., 1934, cviii, 662-669. CrossrefGoogle Scholar10. DÜNNEROSTERTAGTHANNHAUSER LBS: Klin. Wchnschr., 1933, xii, 1054-1056. CrossrefGoogle Scholar11. LONGBISCHOFF MLF: Jr. Nutr., 1929-30, ii, 245-249. Google Scholar12. LOEBNICHOLSPAIGE RFEGBH: Arch. Int. Med., 1931, xlviii, 70-81. CrossrefGoogle Scholar13. HILLHOWITT DWFO: Insulin. Hutchinson's Scientific and Technical Publications, 1936. Google Scholar14. FISCHER F: Münch. med. Wchnschr., 1927, lxxiv, 680-682. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication February 26, 1938.From the Polyclinic Hospital, New York City, and St. Michael's Hospital, Newark, New Jersey.Reference may be made to the first paper of this series concerning the effect of insulin with spontaneous eating (New England Jr. Med., July 21, 1938).†With the technical assistance of James H. Rice. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByExperimentelle Untersuchungen über die Wirkung hoher Insulindosen auf das Myokard von Kaninchen 1 February 1939Volume 12, Issue 8Page: 1263-1278KeywordsCarbohydratesEatingGlucoseHyperglycemiaInsulinStomachToxicity Issue Published: 1 February 1939 PDF DownloadLoading ...