tbuckley/cabot-search huggingface dataset:
Abstract B43: Gene expression in breast tissue associated with mammographic density in healthy women
Authors: Vilde D. Haakensen, Margarethe Biong, Ole Christian Lingjærde, Marit Muri Holmen, Jan Ole Frantzen, Chen Ying, Dina Navjord, Linda Romundstad, Hiroko K. Solvang, Kristensen N. Vessela, Giske Ursin, Anne-Lise Børresen-Dale, Åslaug Helland
Journal: Clinical Cancer Research (2010)

Abstract Introduction: Mammographic density (MD), as assessed from film screen mammograms, is determined by the relative content of adipose, connective and epithelial tissue in the female breast. In epidemiological studies, high MD confers a four to six fold risk elevation of developing breast cancer, even after adjustment for other known breast cancer risk factors. However, the biologic correlates of MD are virtually unknown. Methods: Gene expression analysis using whole genome arrays was performed on breast biopsies from 143 women; 79 women with no malignancy (healthy women) recruited through mammographic centres and 64 newly diagnosed breast cancer patients. MD percentage was determined using a previously validated, computerized method on scanned mammograms. Unsupervised hierarchical clustering was used to investigate the presence of subgroups of samples within the normal biopsies. Significance analysis of microarrays (SAM) was performed to identify genes associated with MD. Results: Hierarchical clustering of normal biopsies on the basis of the gene expression data split the individuals into two main groups. These were not significantly associated with MD or BMI. SAM identified 24 genes differentially expressed between high and low MD in the healthy women. Several single nucleotide polymorphisms (SNPs) associated with the expression of these 24 genes were identified. Conclusions: Breast biopsies from healthy women show substantial variation in their gene-expression profiles. Twenty-four genes associated with MD and SNPs associated with their expression were identified. Several of these genes have previously been found to be linked to breast biology and oestrogen metabolism. Validation and further analysis of these genes is ongoing. Citation Information: Clin Cancer Res 2010;16(7 Suppl):B43
Articular scan in patients with rheumatoid arthritis: a possible method of quantitating joint inflammation usine radio-technetium.
Authors: K Whaley, A I Pack, J A Boyle, W C Dick, W W Downie, W W Buchanan, F C Gillespie
Journal: Annals of the Rheumatic Diseases (1969)

Discussion.-PROF.I. M. Rorrr (Middlesex Hospital) suggested that any lymphocyte might become a "killer" if exposed to a non-specific stimulus such as an antigenantibody complex or aggrated gamma-globulin plus com- plement.DR. MACLENNAN agreed that this was a possible explanation.He produced experimental evidence which suggested that complement components were unlikely to play a significant part in his particular experiments.DR.M. K. JASANI (Horsham) asked if the increased cytotoxicity could be due to stimulation of lymphocytes by an antigen present in synovial fluid.DR. MACLENNAN thought that, in his series of experiments, this possibility could be excluded.Measurement of Lumbar Spine Motion in Population Studies.By I. F. MACRAE and V. WRIGHT (Leeds): In both the Rome (1961) and New York (1967) recommenda- tions for diagnostic criteria in population studies of ankylosing spondylitis, limitation of motion of the lumbar spine is one of the clinical criteria.In the design state of a family survey to detect the pre- valence of ankylosing spondylitis, it became apparent that no suitable method for assessing motion of the lumbar spine was in current use.For this purpose a suitable method should be objective, simple and rapid to perform, and fulfil requirements regarding reliability and sensitivity.A method based upon measurement of the distraction of marks on the skin overlying the vertebral spines in flexion was devised and evaluated.It was shown that there was a high degree of correlation between the measurement and the flexion of the lumbar spine deter- mined radiographically.The method was applied in the survey described and the data on lumbar spine motion related to sex, age and radiographic findings were presented.Discussion.-A number of speakers, whilst agreeing that this method of measuring of movement in the lumbar spine was simple and useful in population studies, con- sidered that it would be of less value in assessing the progress of the individual established case of spondylitis.
Radiofrequency current directed across the mitral anulus with a bipolar epicardial-endocardial catheter electrode configuration in dogs.
Authors: W M Jackman, K H Kuck, G V Naccarelli, L Carmen, J Pitha
Journal: Circulation (1988)

This study tested the capability of low-power radiofrequency current delivered through a bipolar "epicardial-endocardial" catheter electrode configuration to produce discrete epicardial left atrial (LA) and left ventricular (LV) necrosis adjacent to the mitral anulus for potential application in ablating left free-wall accessory atrioventricular pathways. In 15 anesthetized, closed-chest dogs, a 6F electrode catheter was inserted via the jugular vein into the coronary sinus (CS). A second catheter was inserted via the femoral artery into the left ventricle and positioned beneath the mitral valve, high against the anulus, and directly opposite the CS electrode. The LV tip electrode was positioned to record the largest LA potential to ensure proximity to the anulus. Thirty-four sites were tested (five anterior, 14 lateral, and 15 posterior). Radiofrequency current (continuous wave, 625 kHz) was delivered between the CS and LV electrodes at 37-55 V (median, 41 V) for 4-60 seconds (median, 20 seconds). Current ranged from 0.10 to 0.35 A (median, 0.18 A), resulting in power ranging from 4.3 to 19.2 W (median, 7.3 W) and total energy of 51-446 J (median, 152 J). Dogs were sacrificed 2-9 days later. The CS was grossly intact in all dogs and thrombosed in one dog. The circumflex artery was grossly normal in all dogs. Necrosis of a small segment of the arterial wall was found microscopically in one dog. Lesions were identified at 30 of the 34 sites. Twenty-two (73%) of the 30 lesions consisted of a cylindrical-shaped area of necrosis extending between the anulus and CS with diameter ranging from 2.1 to 15.0 mm (median, 4.0 mm). Atrial and ventricular epicardial necrosis extended 0-7.0 mm (median, 2.5 mm) and 0-6.8 mm (median, 2.6 mm) beyond the anulus, respectively. At the remaining eight (27%) sites, little or no epicardial injury occurred, possibly because of downward displacement of LV electrode (four sites) or positioning of LV electrode within a trabecular recess (four sites). We conclude that 1) radiofrequency current delivered between CS and LV produced, at 22 (65%) of 34 sites, LA and LV necrosis adjacent to the anulus without rupture of the CS and that 2) large, sharp LA potentials help identify an optimal anular location of LV electrode. This technique may have clinical usefulness for ablating left free-wall accessory atrioventricular connections.
Calcium-Channel Antibodies in the Lambert–Eaton Syndrome and Other Paraneoplastic Syndromes
Authors: Vanda A. Lennon, Thomas J. Kryzer, Guy E. Griesmann, Padraig E. O'Suilleabhain, Anthony J. Windebank, Andreas Woppmann, George P. Miljanich, Edward H. Lambert
Journal: New England Journal of Medicine (1995)

Voltage-gated calcium channels in small-cell lung carcinomas may initiate autoimmunity in the paraneoplastic neuromuscular disorder Lambert–Eaton syndrome. The calcium-channel subtype that is responsible is not known.
Neuraminidase inhibitors--the story behind the Cochrane review
Authors: P. Doshi
Journal: BMJ (2009)

Although billions have been spent on oseltamivir in the face of pandemic influenza, the team updating the Cochrane review of neuraminidase inhibitors in healthy adults found that the public evidence base for this global public health drug was fragmented and inconsistent. <b>Peter Doshi </b>tells the story
The role of exercise in prevention and in the treatment of coronary heart disease. Exercise in coronary disease.
Authors: T. Semple
Journal: British Journal of Sports Medicine (1976)

Coronary heart disease is a common but not inevitable eventual consequence of longstanding coronary artery disease.At some apparently fortuitous stage of this rusting and blocking affection of its supplying arteries, the heart muscle may suffer minor or major damage in a dramatic or in a more chronic fashion.
Abstract 1562: Choosing the right preclinical model for cancer immunotherapy: The “SyngenOmic” toolbox..
Authors: James A. Harper, John Prime, Athula Herath, Jane Howell, Marianna Papaspyridonos, Amy Popple, Judith Anderton, Michelle Morrow, Arthur Lewis, Liz Henley, Matthew McCourt, Richard Sainson
Journal: Cancer Research (2013)

Abstract Recent FDA approvals of ipilimumab and sipuleucel-T for the treatment of metastatic melanoma and castrate-resistant prostate cancer respectively have validated the approach to modulate the immune system for the clinical treatment of cancer. MedImmune Oncology, has an extensive pipeline and expertise in investigational Immune Mediated Therapy in Cancer (IMT-C) drugs (e.g. tremelimumab and MEDI4736), and is heavily invested in this novel era of cancer therapeutics. Pre-clinical assessment of the validity of potential IMT-C drugs can be enabled by the use of syngeneic tumours established in immuno-competent animals. MedImmune's pharmacology team has lead efforts to develop such models, to a point that a panel of 15 different validated syngeneic tumour types is available in house for studies to progress projects. The intention of selecting relevant models and of minimizing animal experimentation, reduces the number of models tested for each project, and allows for detailed genetic and proteomic characterization of treatment dependent effects within our models. Utilising both in vitro and in vivo approaches, we have generated transcriptomic and genomic data for our cell lines, the resulting implanted tumours and for the relevant lymphatic organs (draining lymph node and spleen). Using key proteomic/cell markers through IHC and FACS analysis, we are also evaluating the immune profile/status of our tumour bearing animals in parallel. Finally, in order to establish the disease relevance and prognostic value of our models we are analyzing our cell panel for the presence of somatic mutations in 50 genes previously implicated in human cancers. Once completed, the resulting dataset will hopefully help pre-clinical scientists to refine their in vivo plans and deliver more clinically-relevant pharmacology packages for the progression of cancer immunotherapy drug candidates. Citation Format: James A. Harper, John Prime, Athula Herath, Jane Howell, Marianna Papaspyridonos, Amy Popple, Judith Anderton, Michelle Morrow, Arthur Lewis, Liz Henley, Matthew McCourt, Richard Sainson. Choosing the right preclinical model for cancer immunotherapy: The “SyngenOmic” toolbox. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1562. doi:10.1158/1538-7445.AM2013-1562
Le dépistage du cancer colorectal par coloscopie
Authors: P Strock, J Mossong, J Weber
Journal: Endoscopy (2007)

Le but de notre étude rétrospective était de réaliser une analyse descriptive de toutes les coloscopies effectuées parmi les patients adultes dans notre centre entre 1994 et 2005 à l'exclusion des pathologies à risque particulier (Crohn, rectocolite, antécédent personnel de cancer colorectal, histoire de Lynch ou polypose familiale).
p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
Authors: Michel Warny, Andrew C. Keates, Sarah Keates, Ignazio Castagliuolo, Jeff K. Zacks, Samer Aboudola, Amir Qamar, Charalabos Pothoulakis, J. Thomas LaMont, Ciarán P. Kelly
Journal: Journal of Clinical Investigation (2000)

Clostridium difficile toxin A causes acute neutrophil infiltration and intestinal mucosal injury. In cultured cells, toxin A inactivates Rho proteins by monoglucosylation. In monocytes, toxin A induces IL-8 production and necrosis by unknown mechanisms. We investigated the role of mitogen-activated protein (MAP) kinases in these events. In THP-1 monocytic cells, toxin A activated the 3 main MAP kinase cascades within 1 to 2 minutes. Activation of p38 was sustained, whereas stimulation of extracellular signal-regulated kinases and c-Jun NH2-terminal kinase was transient. Rho glucosylation became evident after 15 minutes. IL-8 gene expression was reduced by 70% by the MEK inhibitor PD98059 and abrogated by the p38 inhibitor SB203580 or by overexpression of dominant-negative mutants of the p38-activating kinases MKK3 and MKK6. SB203580 also blocked monocyte necrosis and IL-1β release caused by toxin A but not by other toxins. Finally, in mouse ileum, SB203580 prevented toxin A–induced neutrophil recruitment by 92% and villous destruction by 90%. Thus, in monocytes exposed to toxin A, MAP kinase activation appears to precede Rho glucosylation and is required for IL-8 transcription and cell necrosis. p38 MAP kinase also mediates intestinal inflammation and mucosal damage induced by toxin A.
Dermatitis Dysmenorrhœica Symmetrica
Authors: Mark Bernhardt
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Engraftment of distinct clonal MDS-derived hematopoietic precursors in NOD/SCID-β2-microglobulin-deficient mice after intramedullary transplantation of hematopoietic and stromal cells
Authors: Daniella M. Bahia Kerbauy, Vladimir Lesnikov, Beverly Torok-Storb, Eileen Bryant, H. Joachim Deeg
Journal: Blood (2004)
Ga-67 Uptake Unsuppressed by Leukopenia and Intense Antibiotic Therapy
Authors: MIGUEL GORENBERG, DAVID GROSHAR, EINAT EVEN-SAPIR, SIMONA BEN-HAIM, ORA ISRAEL, DOV FRONT
Journal: Clinical Nuclear Medicine (1992)

The authors describe a patient with myelofibrosis who showed intense Ga-67 uptake in spite of being severely leukopenic and receiving large amounts of antibiotics. They conclude that false-negative results associated with leukopenia or intensive antibiotic treatment may not always be correct.
Heterologous Boosting of Recombinant Adenoviral Prime Immunization With a Novel Vesicular Stomatitis Virus–vectored Tuberculosis Vaccine
Authors: Elizabeth K Roediger, Kapilan Kugathasan, XiZhong Zhang, Brian D Lichty, Zhou Xing
Journal: Molecular Therapy (2008)

Pulmonary tuberculosis (TB) remains a serious health problem worldwide. Effective vaccination strategies are needed. We report the development of a novel TB vaccine using vesicular stomatitis virus (VSV) as a viral vector system to express Ag85A. VSVAg85A was shown to be immunogenic when given to mice by either an intranasal or an intramuscular (IM) route. Although distinct T-cell profiles resulted from both routes of immunization, only intranasal delivery generated a mucosal T-cell response that was protective upon pulmonary Mycobacterium tuberculosis (M.tb) challenge. While this protection manifested at an early time-point after immunization, it was not sustained. The potential of VSVAg85A to be used as a mucosal booster for parenteral priming by an adenoviral TB vaccine expressing Ag85A (AdAg85A) was investigated. VSVAg85A immunization markedly boosted antigen-specific T-cell responses in the airway lumen while also augmenting immune activation in the systemic compartment, after AdAg85A priming. This translated into significantly better protective efficacy against pulmonary challenge with M.tb than either vaccine used alone. Our study therefore suggests that VSV as a vector system is a promising candidate to be used in a heterologous viral prime-boost immunization regimen against intracellular bacterial infection. Pulmonary tuberculosis (TB) remains a serious health problem worldwide. Effective vaccination strategies are needed. We report the development of a novel TB vaccine using vesicular stomatitis virus (VSV) as a viral vector system to express Ag85A. VSVAg85A was shown to be immunogenic when given to mice by either an intranasal or an intramuscular (IM) route. Although distinct T-cell profiles resulted from both routes of immunization, only intranasal delivery generated a mucosal T-cell response that was protective upon pulmonary Mycobacterium tuberculosis (M.tb) challenge. While this protection manifested at an early time-point after immunization, it was not sustained. The potential of VSVAg85A to be used as a mucosal booster for parenteral priming by an adenoviral TB vaccine expressing Ag85A (AdAg85A) was investigated. VSVAg85A immunization markedly boosted antigen-specific T-cell responses in the airway lumen while also augmenting immune activation in the systemic compartment, after AdAg85A priming. This translated into significantly better protective efficacy against pulmonary challenge with M.tb than either vaccine used alone. Our study therefore suggests that VSV as a vector system is a promising candidate to be used in a heterologous viral prime-boost immunization regimen against intracellular bacterial infection.
High Dose Adenosine Stress Echocardiography for Noninvasive Detection of Coronary Artery Disease
Authors: Ana D. Djordjevic-Dikic, Miodrag C. Ostojic, Branko D. Beleslin, Jelena Stepanovic, Zorica Petrasinovic, Rade Babic, Sinisa M. Stojkovic, Goran Stankovic, Milan Nedeljkovic, Ivana Nedeljkovic, Vladimir Kanjuh
Journal: Journal of the American College of Cardiology (1996)
Abstract 5460: Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition
Authors: Wataru Okamoto, Isamu Okamoto, Takeshi Yoshida, Erina Hatashita, Yuki Yamada, Kiyoko Kuwata, Tokuzo Arao, Kazuyoshi Yanagihara, Kazuto Nishio, Masahiro Fukuoka, Kazuhiko Nakagawa
Journal: Cancer Research (2010)

Abstract Therapeutic strategies that target c-Src hold promise for a wide variety of cancers. We have now investigated both the effects of dasatinib, which inhibits the activity of c-Src and several other kinases, on cell growth as well as the mechanism of dasatinib resistance in human gastric cancer cell lines. Immunoblot analysis revealed activation of c-Src at various levels in most gastric cancer cell lines examined. Dasatinib inhibited phosphorylation of extracellular signal-regulated kinase (ERK) and induced G1 arrest, as revealed by flow cytometry, in a subset of responsive cell lines. In other responsive cell lines, dasatinib inhibited both ERK and AKT phosphorylation and induced apoptosis, as revealed by an increase in caspase-3 activity and cleavage of poly(ADP-ribose) polymerase. Depletion of c-Src by RNA interference also induced G1 arrest or apoptosis in dasatinib-responsive cell lines, indicating that the antiproliferative effect of dasatinib is attributable to c-Src inhibition. Gastric cancer cell lines positive for activation of MET were resistant to dasatinib. Dasatinib had no effect on ERK or AKT signaling, whereas the MET inhibitor PHA-665752 induced apoptosis, in these cells. The subsets of gastric cancer cells defined by a response to c-Src or MET inhibitors were distinct and nonoverlapping. Our results suggest that c-Src is a promising target for treatment of gastric cancer, and that analysis of MET amplification might optimize patient selection for treatment with c-Src inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5460.
Small FVIII gene rearrangements in 18 hemophilia A patients: Five novel mutations
Authors: Maria Patrizia Bicocchi, Mirella Pasino, Tiziana Lanza, Federico Bottini, Angelo Claudio Molinari, Daniela Caprino, Camillo Rosano, Maura Acquila
Journal: American Journal of Hematology (2005)

Hemophilia A (HA) is a disorder caused by mutations of the FVIII gene, which is located on the tip of the long arm of the X chromosome. In a cohort of 18 unrelated Italian patients affected with HA of varying severity, we performed mutational screening of the gene by denaturing high-performance liquid chromatography (DHPLC) and direct sequencing of abnormal peaks. We identified five novel mutations and 9 previously reported DNA alterations. Two of the 9 previously reported alterations were each common to 3 unrelated patients. Six different mutations were characterized as missense alterations, while 8 were non-missense mutations. Among the new gene alterations, one created a stop codon, one consisted of an out-of frame deletion, and one was a splice-site mutation. The last two were missense alterations. In an attempt to better understand the causative effect of the mutations and the clinical variability of the patients, we investigated the consequences of each missense mutation and visualized the effect of the amino acid change on structural FVIII models. Am. J. Hematol. 78:117–122, 2005. © 2005 Wiley-Liss, Inc.
Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia
Authors: Cassandra D. Josephson, Suzanne Granger, Susan F. Assmann, Marta-Inés Castillejo, Ronald G. Strauss, Sherrill J. Slichter, Marie E. Steiner, Janna M. Journeycake, Courtney D. Thornburg, James Bussel, Eric F. Grabowski, Ellis J. Neufeld, William Savage, Steven R. Sloan
Journal: Blood (2012)