tbuckley/cabot-search huggingface dataset:
Government agencies act on task force findings
Authors: William A. Check
Journal: JAMA (1986)

Since the Department of Health and Human Services was the source of the task force report on the health status of black persons and members of other minority groups, it is not too surprising that several of its agencies have been prompt to respond to the report's findings. For example, the National Heart, Lung, and Blood Institute, Bethesda, Md, has set up a study of risk factors for cardiovascular disease in the black population and a study of the development of obesity in black women. These studies, institute officials point out, respond to one of the needs identified by the tast force—that for better data collection as a first step in coping with the causes of health problems in minority populations. Institute officials say that only one study of hypertension has, to their knowledge, included enough black participants to allow conclusions about whether pharmacologic lowering of blood pressure reduces the
Online With Physicians Accessing the Internet
Authors: Efe Onganer
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The Haydarpasa Numune Hospital, Istanbul, Turkey, has been enthusiastically following the integration of medical knowledge into the Internet framework while keeping itself abreast of the advances in information technology. We have begun to set up a group of health care professionals to explore how to integrate the practice of medicine into the Internet framework and make medical practice more competent while adhering to the principle of patient confidentiality. Like its counterparts the<i>BMJ</i><sup>1</sup>and<i>JAMA</i>,<sup>2</sup>the 40-year-old<i>Haydarpaşa Numune Hospital Medical Journal</i>has joined the variety of journals that are available on the Internet.<sup>3</sup>Our journal can be accessed through the Haydarpasa Numune Hospital World Wide Web site at http://www.kilim.com.tr/ numune. The World Wide Web pages of the<i>Haydarpasa Numune Hospital Medical Journal</i>are designed to fit the needs of the local Turkish health personnel, while opening a pathway to anyone curious about the
For Sale: Physicians' Prescribing Data
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (2006)

Interview with Dr. Jack Lewin on the collection and sale of physicians’ prescribing data. (06:59)Download Since the early 1990s, health care information companies have bought electronic records of prescriptions from pharmacies and other sources and linked them with information about doctors that is licensed from the Physician Masterfile of the American Medical Association (AMA). These information companies, the largest of which is IMS Health of Fairfield, Connecticut, have then compiled and sold individual physicians' prescribing data to pharmaceutical manufacturers. The business is lucrative. But a growing number of physicians have rebelled after becoming aware that drug companies have access to their data — in some cases because zealous sales agents have confronted them with their . . .
Intra-articular urokinase in rheumatoid arthritis.
Authors: R D Sturrock, C Watkin, T Williamson, W C Dick
Journal: Annals of the Rheumatic Diseases (1974)

Ithasbeensuggested that urokinase mayhavesome value inthemanagement ofpatients withrheumatoid arthritis (Morotomi andTatezawa, 1970; Itoand Naito,1970). Thisfibrinolytic agentactivates plasminogen, converting ittoplasmin competitively andreversibly. Thusthere issomebasis, however speculative, foritsuseinrheumatoid arthritis-a disease whichon several clinical andlaboratory grounds maybearsomerelationship tofibrinogen andfibrinolysis (BachAndersen, andGormsen, 1970; Barnhart, Riddle, Bluhm, andQuintana, 1967; Caughey andHighton, 1967). Wehavecompleted asmall study oflocal urokinase treatment incomparison withwatercontrols inthe kneejoints oftenpatients withclassical rheumatoid arthritis (Ropes, Bennett, Cobb, Jacox, andJessar, 1959) andhavemonitored these patients intensively overashort period oftime. Theclinical assessment methodsincluded rangeofkneemovementas measured bya goniometer, thenumberoffull flexions possible in30sec., local kneepain score, and 99mTcuptake.
Abstract 2189: Novel transcriptional regulation of Notch1 by EZH2 in mammary stem cells
Authors: Maria E. Gonzalez, Xin Li, Heather Kruger, Kathy Toy, Celina G. Kleer
Journal: Cancer Research (2012)

Abstract Background: EZH2 has oncogenic functions in the breast and other organs, and has been recently shown to regulate the differentiation of tissue specific stem cells. However, the underlying mechanisms are largely unknown. We hypothesized that EZH2 may regulate mammary stem cells by transcriptional mechanisms of key signaling pathways. Methods: We developed EZH2 KD in SUM149 breast cancer cells, and an inducible and transient cell culture model of EZH2 overexpression, (EZH2-OV), and its deletion mutants in MCF10A and in primary breast cells. Mammary stem cells were identified using ALDH1+ and CD44+/CD24- by FACS. ChIP assays were used to determine EZH2 recruitment to specific areas in NOTCH1 promoter. Ectopic expression of EZH2 and deletion mutants leads to identify the EZH2 domain responsible for the transcription up regulation of NOTCH1. Results: We identified that EZH2 KD in SUM149 significantly decreased NOTCH1 signaling in the stem cell population. We observed preferential expression of EZH2 in the stem cell population of normal primary breast cells compared to non-stem cells. In MCF10A cells, EZ-OV was predominantly increased in the ALDH-1+ population. We found that EZH2-OV increased the stem cell population of MCF10A cells. Consistently, EZH2-OV in MCF10A and primary breast cells increased Notch1 mRNA specifically in the ALDH1+ population. EZH2-OV increased Notch1 protein levels and promoter activity in MCF10A and primary cells. Mechanistically, Notch1 inhibition by GSI reversed the effect of EZH2-OV in the stem cell population of MCF10A cells. ChIP assays revealed that EZH2 is recruited to specific regions of the NOTCH1 promoter depending on EZH2 specific context. Moreover, ChIP assays with EZH2 deletion mutants identify that the Nter- EZH2 HII domain is responsible for the NOTCH1 promoter transcriptional up regulation and that this function is independent of the SET domain (methytransferase activity) and as shown by comparing the EZH2 tri-methylation mark (3H3K27) in the NOTCH1 promoter. Conclusion: Collectively, these results indicate that EZH2 regulates mammary stem cells and requires, at least in part the activation of Notch1 signaling by recruitment of EZH2 to the NOTCH1 promoter through the Nter domain. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2189. doi:1538-7445.AM2012-2189
Genetic Influence on Laterality in Schizophrenia? A Twin Study of Neurological Soft Signs
Authors: Rainer Niethammer, Matthias Weisbrod, Steffi Schiesser, Jo Grothe, Sabine Maier, Uta Peter, Claudia Kaufmann, Johannes Schröder, Heinrich Sauer
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: This study explored the genetic basis of neurological soft signs in schizophrenia and addressed disturbed hemispheric lateralization. METHOD: The authors investigated neurological soft signs in 30 monozygotic twin pairs, 13 pairs discordant for schizophrenia or schizoaffective disorder and 17 healthy comparison twin pairs. RESULTS: The twins with schizophrenia showed higher total scores for neurological soft signs than did the comparison subjects. The total scores for neurological soft signs of the nonaffected discordant twins were significantly higher than those of the comparison twins. There was a significant difference between the nonaffected and affected discordant twins in total scores for neurological soft signs. In contrast to the comparison subjects, the nonaffected and affected twins of the discordant pairs showed a trend toward higher scores for neurological soft signs on the left body half. CONCLUSIONS: These results suggest that the occurrence of neurological soft signs and, more specifically, their lateralization to the left body half are genetically transmitted.
Public Health Effects of Occupational and Environmental Radiation Exposure-Reply
Authors: Seymour Jablon
Journal: JAMA (1991)

<h3>In Reply.</h3> —Gould asserts that, in our reports on cancer in populations living near nuclear facilities,<sup>1,2</sup>we ignored evidence that nuclear power plants are responsible for excess cancer mortality. We do not agree. Gould makes three points: first, that cancer mortality in 1950 to 1959 cannot be compared with what happened later because of the confounding effect of fallout from weapons tests; second, that our comparison counties were inappropriate because they were also affected by radioactive effluents; and finally, that for two thirds of the study areas, cancer mortality after start-up was larger than expected at US rates. Gould is prepared to rely entirely on comparisons with concurrent rates for the entire United States, ignoring local variability associated with occupational, ethnic, and life-style factors for which matched control counties and comparisons of cancer rates before start-up with those afterwards, provide some measure of control. Our article<sup>2</sup>contains data
Immune therapy for treating type 1 diabetes: challenging existing paradigms
Authors: Jay S. Skyler
Journal: Journal of Clinical Investigation (2014)

Patients with type 1 diabetes (T1D) rapidly lose β cell function and/or mass, leading to a life-long dependence on insulin therapy. β Cell destruction is mediated by aberrant immune responses; therefore, immune modulation has potential to ameliorate disease. While immune intervention in animal models of diabetes has shown promising results, treatment of patients with T1D with the same agents has not been as successful. In this issue of the JCI, Haller and colleagues present data from a small clinical trial that tested the efficacy of a combination of immunomodulatory agents, anti-thymocyte globulin and pegylated granulocyte CSF, neither of which have shown benefit for T1D as single treatment agents. Many patients that received combination therapy maintained β cell function at baseline levels up to a year after treatment. The results from this study challenge current trial design paradigm that for combined therapy to be successful individual agents should show benefit.
Marriage A-la-Mode
Authors: M. Baum, S. Di Nepi
Journal: BMJ (2009)

London’s National Gallery contains a rich source of material that is of value in the teaching of doctors as well as art historians. Among our favourites is Hogarth’s Marriage A-la-Mode , a set of six paintings made by the artist in 1743 as models for engravings. First published two years later, the prints became instantly popular and have never ceased to be reproduced. After passing through the hands of several collectors the famous series entered the National Gallery in 1824 with the founding purchase of financier John Julius Angerstein’s collection. 

Its sequence of …
The pitfalls of hair analysis for toxicants in clinical practice: three case reports.
Authors: Melissa Frisch, Brian S Schwartz
Journal: Environmental Health Perspectives (2002)

Hair analysis is used to assess exposure to heavy metals in patients presenting with nonspecific symptoms and is a commonly used procedure in patients referred to our clinic. We are frequently called on to evaluate patients who have health-related concerns as a result of hair analysis. Three patients first presented to outside physicians with nonspecific, multisystemic symptoms. A panel of analytes was measured in hair, and one or more values were interpreted as elevated. As a result of the hair analysis and other unconventional diagnostic tests, the patients presented to us believing they suffered from metal toxicity. In this paper we review the clinical efficacy of this procedure within the context of a patient population with somatic disorders and no clear risk factors for metal intoxication. We also review limitations of hair analysis in this setting; these limitations include patient factors such as low pretest probability of disease and test factors such as the lack of validation of analytic techniques, the inability to discern between exogenous contaminants and endogenous toxicants in hair, the variability of analytic procedures, low interlaboratory reliability, and the increased likelihood of false positive test results in the measurement of panels of analytes.
Clinical and Antibody Responses After Influenza Immunization in Systemic Lupus Erythematosus
Authors: James S. Louie, Kenneth M. Nies, Kent T. Shoji, Ronald C. Fraback, Christine Abrass, Wayne Border, James D. Cherry, David Imagawa
Journal: Annals of Internal Medicine (1978)

After immunization with A/New Jersey/76 and A/Victoria/75 influenza vaccines, 11 patients with systemic lupus erythematosus were serially evaluated for changes in disease activity, serologic abnormalities, and their capability to generate specific antibodies. One patient, with active disease, developed a diffuse, proliferative glomerulonephritis. None of the other patients or control subjects had significant local or systemic side effects. Significant levels of antibodies were generated to A/New Jersey/76 in eight of the 11 patients and in seven of eight control subjects and to A/Victoria/75 in seven of 11 patients and five of eight control subjects. The geometric mean responses of both total and IgG antibodies to each viral antigen were no different in patients with systemic lupus erythematosus than in control subjects. In patients with stable systemic lupus erythematosus, immunization with killed influenza viral vaccine appears to be safe and effective.
Familial Hyperthyroxinemia Due to Abnormal Thyroid Hormone Binding
Authors: JAY D. H. SILVERBERG
Journal: Annals of Internal Medicine (1982)

A patient had an elevated serum total thyroxine (T4) free thyroxine (free T4), free T4 index, and T4/thyroxine-binding globulin ratio. The serum triiodothyronine (T3), as well as the thyrotrophin response to thyrotrophin-releasing hormone was normal and consistent with the clinical euthyroid status. The basis for the elevated serum total T4, free T4 index, and T4/thyroxine binding globulin is the abnormally enhanced binding of thyroid hormone by albumin, or by an anomalous protein migrating with a mobility similar to albumin as determined in paper electrophoretic systems. The abnormal T4 protein binding was also seen in several members of the patient's family indicating that the condition was familial. A new type of serum T4 protein binding abnormality that results in hyperthyroxinemia may falsely indicate thyrotoxicosis in clinically euthyroid subjects.
Controlled Trials for Neonatal Meningitis-Reply
Authors: George H. McCracken
Journal: JAMA (1985)

In Reply.—  There are many factors that influence the predisposition to and outcome from bacterial meningitis in newborns. The prospective, randomized controlled designs of the three Neonatal Meningitis Cooperative Studies attempted to distribute risk factors among the therapeutic groups in order to compare an untested therapeutic regimen with conventional therapy. Given the vicissitudes of coordinating many centers throughout the world in the projects, we were generally successful in having comparable population characteristics in the different treatment groups. Although not mentioned in our article describing the results of the Third Neonatal Meningitis Cooperative Study, there were no differences in the rates or types of obstetrical complications in infants who received ampicillin and moxalactam compared with those receiving ampicillin and amikacin sulfate.  Because infants enrolled from centers in Latin America were older and had a different distribution of etiologic agents than did those from the United States and Europe, we analyzed and
Acute Renal Failure Precipitated by Quinine Sulfate in Early Pregnancy
Authors: Patricia A. Lang, Carroll C. Jones
Journal: JAMA (1964)

ACUTE RENAL FAILURE during pregnancy or immediately postpartum accounts for 20% to 40% of all cases of acute renal failure.<sup>1,2</sup>In the majority of these cases, renal failure results from ischemic tubular necrosis following shock precipitated by uterine hemorrhage or massive intravascular hemolysis<sup>1,3</sup>following incompatible blood transfusions. Occasionally, bilateral renal cortical necrosis is responsible for the acute renal failure of these patients.<sup>1,4</sup> Although rarely reported, quinine sulfate used as an abortifacient, or for some other purpose in the first trimester of pregnancy, may cause massive intravascular hemolysis followed by ischemic tubular necrosis and acute renal failure.<sup>5-9</sup>A patient exhibiting acute renal failure following the ingestion of quinine sulfate during the eighth week of pregnancy has been studied. In this patient, uremia was controlled and complete recovery followed intensive medical management which included peritoneal dialysis. <h3>Report of a Case</h3> A 28-year-old Negro female entered the hospital on
(45) Linear porokeratosis and disseminated superficial actinic porokeratosis
Authors: J.S. Dover, J. Miller, G.M. Levene
Journal: British Journal of Dermatology (1985)

Journal Article (45) Linear porokeratosis and disseminated superficial actinic porokeratosis Get access J.S. Dover, J.S. Dover St John's Hospital for Diseases of the Skin, London WC2 Search for other works by this author on: Oxford Academic Google Scholar J. Miller, J. Miller St John's Hospital for Diseases of the Skin, London WC2 Search for other works by this author on: Oxford Academic Google Scholar G.M. Levene G.M. Levene St John's Hospital for Diseases of the Skin, London WC2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 91–92, https://doi.org/10.1111/j.1365-2133.1985.tb13060.x Published: 01 July 1985
Improving Lifetime Health by Promoting Behavioral Health in Children
Authors: Thomas F. Boat
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comorbidities and Impairments Explaining the Association Between Diabetes and Lower Extremity Disability
Authors: Stefano Volpato, Caroline Blaum, Helaine Resnick, Luigi Ferrucci, Linda P. Fried, Jack M. Guralnik
Journal: Diabetes Care (2002)

OBJECTIVE—To elucidate the role of diabetes-related impairments and comorbidities in the association between diabetes and physical disability, this study examined the association between diabetes and lower extremity function in a sample of disabled older women. RESEARCH DESIGN AND METHODS—Cross-sectional analysis of 1,002 women (aged ≥65 years) enrolled in the Women’s Health and Aging Study (one-third most disabled of the total community-dwelling population). Diabetes and other medical conditions were ascertained by standard criteria that used multiple sources of information. Functional status was assessed using self-reported and objective performance measures. RESULTS—Women with diabetes were significantly more likely to have cardiovascular diseases, peripheral nerve dysfunction, visual impairment, obesity, and depression. After adjustment for age, women with diabetes had a greater prevalence of mobility disability (odds ratio [OR] 1.85, 95% CI 1.12–3.06), activities of daily living disability (1.61, 1.06–2.43), and severe walking limitation (2.34, 1.56–3.50), and their summary mobility performance score (0–12 scale based on balance, gait speed, chair stands) was 1.4 points lower than in nondiabetic women (P &amp;lt; 0.001). Peripheral artery disease, peripheral nerve dysfunction, and depression were the main individual contributing factors; however, none of these conditions alone fully explained the association between diabetes and disability. Conversely, only after adjusting for all potential mediators was the relationship between diabetes and disability reduced to a large degree. CONCLUSIONS—Even among physically impaired older women, diabetes is associated with a major burden of disability. A wide range of impairments and comorbidities explains the diabetes-disability relationship, suggesting that the mechanism for such an association is multifactorial.
Mechanisms of Fractionated Electrograms Formation in the Posterior Left Atrium During Paroxysmal Atrial Fibrillation in Humans
Authors: Felipe Atienza, David Calvo, Jesús Almendral, Sharon Zlochiver, Krzysztof R. Grzeda, Nieves Martínez-Alzamora, Esteban González-Torrecilla, Ángel Arenal, Francisco Fernández-Avilés, Omer Berenfeld
Journal: Journal of the American College of Cardiology (2011)
The Unintended Consequences of Bundled Payments
Authors: William B. Weeks, Stephen S. Rauh, Eric B. Wadsworth, James N. Weinstein
Journal: Annals of Internal Medicine (2013)

Consensus is building that episode-based bundled payments can produce substantial Medicare savings, and the Center for Medicare & Medicaid Innovation's Bundled Payment Initiative endorses this concept. The program generates potential cost savings by reducing the historic cost of time-defined episodes of care, provided through a discount. Although bundled payments can reduce waste primarily in the postacute care setting, concerns arise that, in an effort to maintain income levels that are necessary to cover fixed costs, providers may change their behaviors to increase the volume of episodes. Such actions would mitigate the savings that Medicare might have accrued and may perpetuate the fee-for-service payment mechanism, with episodes of care becoming the new service. Although bundled payments have some advantages over the current reimbursement system, true cost-savings to Medicare will be realized only when the federal government addresses the use issue that underlies much of the waste inherent in the system and provides ample incentives to eliminate capacity and move toward capitation.