tbuckley/cabot-search huggingface dataset:
Unusual Long-term Complication after Endoscopic Sphincterotomy: Stone Formation in the Gallbladder
Authors: S. Matsumoto, H. Yoshimoto, M. Tanaka, S. Ikeda
Journal: Endoscopy (1985)

Long-term complications of endoscopic sphincterotomy hitherto reported consist of recurrent common bile duct stones, cholangitis, cholecystitis and stenosis of the sphincterotomy opening. A case of unusual late complication - formation of new stones in the gallbladder - is described and consideration is given to the etiology.
Hepatobiliary candidiasis in chronic lymphatic leukaemia.
Authors: C. N. Hacking, M. J. Goodrick, M. Chisholm
Journal: BMJ (1989)

Hepatobiliary candidiasis in chronic lymphatic leukaemiaA 64 year old woman with longstanding chronic lymphatic leukaemia presented after six weeks' fever and cough.On examination she had a fever and severe oral candidiasis, signs of pneumonia, mild jaundice, and tender hepatomegaly.A chest x ray film showed bilateral interstitial pneumonia.Ultrasonography and subsequent endoscopic retrograde cholangiopancreatographic examination showed a widespread intraductal biliary cast (white arrows) and multiple small communicating microabscesses (black arrows) (figure).Ultra- sound guided biopsy and microscopy showed fungal mycelia, later identified as Candida albicans.Despite intensive antifungal treat-
Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24 577 first-degree relatives of 11 039 patients with myeloproliferative neoplasms in Sweden
Authors: Ola Landgren, Lynn R. Goldin, Sigurdur Y. Kristinsson, Elin A. Helgadottir, Jan Samuelsson, Magnus Björkholm
Journal: Blood (2008)
Cigarette Tax for National Health Care
Authors: Robert W. Schrier
Journal: Annals of Internal Medicine (1993)

Letters15 August 1993Cigarette Tax for National Health CareRobert W. SchrierRobert W. SchrierSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-4-199308150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The Centers for Disease Control and Prevention estimated that, in 1991, 435 000 Americans died of tobacco-related diseases such as cancer and heart and lung diseases, accounting for 20% of the total annual deaths independent of the effects of passive smoking on other Americans. The human and economic costs of tobacco use to American citizens are devastating, especially for children, women, minorities, and the elderly. The economic costs of tobacco use in this country are estimated at $65 to $100 billion per year. For these reasons, the American Heart Association, the American Lung Association, and the American ... Author, Article, and Disclosure InformationAuthors: Robert W. SchrierAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1993Volume 119, Issue 4Page: 346KeywordsCancer preventionCardiovascular therapyChildrenElderlyHealth careHeartHeart diseasesLung and intrathoracic tumorsLungsTaxes ePublished: 15 August 2000 Issue Published: 15 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinical evaluation of Pharmacia CAP System<sup>™</sup> RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy
Authors: M. Blanca, C. Mayorga, M. J. Torres, M. Reche, C. Moya, J. L. Rodriguez, A. Romano, C. Juarez
Journal: Allergy (2001)

Background: The diagnosis of IgE‐mediated immediate reactions to penicillins can be supported by in vivo or in vitro tests using classical benzylpenicillin determinants. The wide variety of β‐lactams and the description of new specificities requires a re‐evaluation of the different tests available. The objective was to evaluate the diagnostic capacity of Pharmacia CAP System ™ RAST FEIA amoxicilloyl c6 (AXO) and benzylpenicilloyl c1 (BPO) in patients with a documented IgE‐mediated penicillin allergy. Methods: We studied 129 patients in five groups. Groups 1, 2, and 3 had developed an immediate reaction after penicillin treatment. Group 1 ( n =19) were skin test positive to amoxicillin (AX) and/or BPO and/or minor determinant mixture (MDM); group 2 ( n =29) were skin test positive to AX but negative to BPO and MDM; and group 3 ( n =26) were skin test negative to all determinants, the diagnosis being confirmed by a previous repetitive history or controlled administration. Two control groups, one with nonimmediate reactions – group 4 ( n =25) – and one with good tolerance to penicillin – group 5 ( n =30) – were included. All samples were analyzed in vitro for AXO and BPO, and the results compared to the in vivo diagnosis. Results: AX was the drug most often involved. In group 1, 53% were in vitro positive for AXO and 68% for BPO, but 74% had at least one positive test result. In group 2, only 10% had a positive in vitro test to BPO compared to 41% to AXO. In group 3, 42% had positive BPO and/or AXO in vitro tests. In the control groups 4 and 5, the negative in vitro results for AXO were 96% and 100%, and for BPO 100% and 97%, respectively. A positive correlation between specific IgE levels and the time interval from the reaction to the evaluation was found only for group 3. Conclusions : This in vitro assay is beneficial for evaluating subjects allergic to β‐lactams. It is necessary to test for specific IgE to AXO in addition to BPO in patients with immediate allergic reactions after AX. The combination of in vivo and in vitro tests for estimating IgE antibodies to penicillins is important because of the existence of patients with a positive history but negative skin test.
Carbohydrates in Diabetes.
Authors: W. H. Ten Broeck
Journal: JAMA (1897)

Paris, Ill. <h3>To the Editor:</h3> —I think Dr. E. L. Munson is right in allowing a moderate amount of carbohydrates in diabetes mellitus. I have done so for the last eight years, and the results have been better than under a strict proteid diet. I also allow the patient to drink all the water he wants, because it dilutes the urine and makes it less irritable to kidneys and bladder and, I think, lessens the danger of coma. Respectfully,
AN UNUSUAL CASE OF MERCURIAL POISONING
Authors: Jeannette M. Shefferd
Journal: JAMA (1925)

A man, aged 29, Greek, a waiter, whose history was negative, entered the hospital, Dec. 15, 1924, having observed a painless swelling that had begun on the left side of the face. The tongue was heavily coated at the center and red at the edges; the teeth were heavily covered with tartar, but were not tender. There was pyorrhea aveolaris. The openings of the sublingual ducts were swollen. The whole mucous membrane of the hard and soft palate and the cheeks and alveoli, sublingual space and tongue were thickly, and almost completely, covered with bluish white patches varying in size from a pin-point to half the thumb, not indurated or elevated. The breath had a foul, mercurial odor, and the neck and glands were badly swollen. The patient was uncomfortable but not in great pain. The white cell count was 12,000. The temperature ranged from 99 to 100 F. Cultures
Address on the Progress of Medicine
Authors: J. R. Wardell
Journal: BMJ (1874)

nourishment or stimulants, you will have to seek medicinal mealns of subduing it, as such excitemenit soon ends in irremediable exhaustion.Opiuin, howrever, must lnot be included amongst these means.Its action.is always ambiguous in old age, and in senile dementia those deg,enerative clhaniges in the vessels, wAhich are so frequently present, contraindicate its use.Even wlhere the vessels are sound it may be hurtful, by strengthening the tendency to that vague drowsiness which is apt to lapse inito coma, with effusion of serum, or by disordering the functions of the prinia vize.I should say that it is almost alwvays contra- indicated in senile dementia.A less dangerous sedative is found in hyoscyamus, whlich will generally secure repose in such cases, without doing damage in any other direction.I can attest its value, from long experience of it in senile dementia.Beginning with a drachm dose of the tincture, or succus, we increase the amount, until its soothing influ- ence is manifested, and rarely require to'exceed lhalf an ounce as a dose.If hyoscvamus fail, cannabis Inidica may be tried, with great caution.Chiloral, as you knov, I do not employ in such cases.When the ex- citement coexists, with a copious excretion of lithates from the kidneys, it may sometimes be mitigated by the adcministration of alkalies.If muscular tremblinig be excessive, conium in large doses (from two to four drachms) of the succus will probably prove a palliative.Car- bonate of iron or spirit of turpentine often also affords some relief.
THE FUNCTION OF THE ADRENAL CORTEX
Authors: EDWARD C. KENDALL
Journal: JAMA (1941)

When the adrenal glands are removed from laboratory animals, symptoms of deficiency develop, which may be summarized as follows: The first notable change is usually a loss of appetite, which is soon followed by nausea, vomiting, increased peristalsis and eventually bloody diarrhea. Associated with these changes are profound weakness of the muscles and a listless stupor, or, in some animals, restlessness and marked salivation, with clonic movements and general convulsions similar to those observed in hypoglycemia induced by insulin. There is a gradual decrease in body temperature and a decrease in the basal metabolic rate. Continuance of the state of adrenal deficiency is invariably associated with a decrease in blood pressure to the death level, an increase in the hematocrit reading and a progressive decrease in the volume of the circulating blood. Soon after removal of the adrenal glands there is a marked and continuous increase in the concentrations of
Treatment-related mortality and graft-versus-leukemia activity after allogeneic stem cell transplantation for chronic lymphocytic leukemia using intensity-reduced conditioning
Authors: P Dreger, R Brand, J Hansz, D Milligan, P Corradini, J Finke, G L Deliliers, R Martino, N Russell, A van Biezen, M Michallet, D Niederwieser
Journal: Leukemia (2003)
The Surgical Relief of Aortic Stenosis by Means of Apical—Aortic Valvular Anastomosis
Authors: STANLEY J. SARNOFF, THOMAS J. DONOVAN, ROBERT B. CASE, PHILIP E. WAITHE
Journal: Circulation (1955)

A means has been devised whereby the aortic valve can be effectively by-passed. Left ventricular blood leaves via the apex through a lucite tube in continuity with a modified Hufnagel valve and then enters the thoracic aorta. In dogs so treated the ascending arch of the aorta may be totally and permanently occluded without apparent impairment of the circulation. Postoperatively these dogs run, jump and swim and are not readily distinguishable from normal dogs. The entire ventricular manipulation is completed in 30 to 60 seconds. The applicability of this procedure to the alleviation of aortic stenosis in man is discussed.
Who measures the Holy Dread?
Authors: Kevin Barraclough
Journal: BMJ (2005)

If you tell patients that a drug is shown in a trial to reduce their absolute risk by 0.2% per year they usually don't want it. They weigh the marginal absolute benefit against the harm of being “medicalised,” and they decline. The opinion forming “experts” who ran the trial take a different view. The experts demonstrate the relative risk reduction with bar charts at a string of lucrative international conferences. They sit on the guidelines …
Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat.
Authors: O D Mjos, O Faergeman, R L Hamilton, R J Havel
Journal: Journal of Clinical Investigation (1975)

The metabolism of intravenously injected large and small chylomicrons from intestinal lymph and of very low density lipoproteins from blood plasma was studied in functionally eviscerated "supradiaphragmetic" rats. For studies with lymph lipoproteins, recipient animals were injected with 4-amino-pyrazolopyrimidine 18 h before injection of lipoprotein to prevent secretion of very low density lipoproteins into their blood plasma. In all cases, most of the triglycerides (labeled with 14C) were rapidly metabolized, whereas cholesteryl esters (labeled with 3H) persisted in the blood. Most of the cholesteryl esters remained in smaller "remnant" lipoproteins, less dense that 1.006, which retained an apparently spherical shape, as determined by electron microscopy of negatively stained preparations. Whereas the diameters and chemical compositions of large chylomicrons were substantially different from those of small chylomicrons and very low density lipoproteins, all remnants were similar in these respects. Average remnant diameters were 400-600 A and remnants were enriched in cholesteryl esters and in protein insoluble in tetramethylurea. In addition to triglycerides, remnants were depleted of phospholiarticle size, the composition of remnants, like that of their precursors, was consistent with the "pseudomicellar" model of lipoproteins, in which a core of nonpolar lipids is covered by a monolayer of polar lipids and protein. These results domonstrate the fundamental similarity of the initial step in the metabolism of triglyceride-rich lipoproteins from intestinal mucosa and liver and show that loss of triglycerides from the core of the particles is accompanied by removal of polar components from the surface.
Secrecy in Medical Research
Authors: S A Rosenberg
Journal: New England Journal of Medicine (1996)

The conduct of medical research is in increasing jeopardy. Scarce funds for research have been strained by the emergence of new problems requiring intensive work. But a more insidious problem is compromising the ability to make progress in medical research. Secrecy about methods and results has become a common and accepted practice. The complex legal arrangements that are often required before reagents are shared impedes scientists from acquiring the materials needed to perform their work. These impediments to research appear to be arising more frequently. The following four situations, which I encountered in the past several months, illustrate many of . . .
The Conservative Management of Fecal Incontinence in Children
Authors: Donita B. Sullivan
Journal: JAMA (1963)

FECAL INCONTINENCE in a child over 3 years of age becomes a matter of most serious psychological and social importance, increasing with age. We have developed a program for controlling this condition, which, with modification, has been successful in children whose difficulty results from various causes ranging from gross anatomical abnormalities and faulty innervation to "overtraining" and overt psychiatric disease. Emotional problems are commonly associated with fecal incontinence, sometimes as a causative factor, or inevitably as a direct result of the social disgrace of fecal soiling. Although these emotional problems are important, we will confine our discussion to the nonpsychiatric, medical management. <h3>Anatomic Causes</h3> Included in the group of patients we have had the opportunity to treat, are children with myelodysplasia; children with paraplegia secondary to infectious transverse myelitis or vascular accidents of spinal arteries; children with traumatic transection of the spinal cord; and children who have no anal sphincters,
IL-17 Enhances TNF-α-Induced, But Not IL-1β-Induced, Expression Of Neutrophil-Associated Cytokines By Human Lung Tissue Cells
Authors: Akio Matsuda, Kenichiro Motomura, Tetsuo Shoda, Kyoko Futamura, Hirohisa Saito, Kenji Matsumoto
Journal: Journal of Allergy and Clinical Immunology (2014)
t-PA–specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes
Authors: Be'eri Niego, Roxann Freeman, Till B. Puschmann, Ann M. Turnley, Robert L. Medcalf
Journal: Blood (2012)

Tissue-type plasminogen activator (t-PA) can modulate permeability of the neurovascular unit and exacerbate injury in ischemic stroke. We examined the effects of t-PA using in vitro models of the blood-brain barrier. t-PA caused a concentration-dependent increase in permeability. This effect was dependent on plasmin formation and potentiated in the presence of plasminogen. An inactive t-PA variant inhibited the t-PA-mediated increase in permeability, whereas blockade of low-density lipoprotein receptors or exposed lysine residues resulted in similar inhibition, implying a role for both a t-PA receptor, most likely a low-density lipoprotein receptor, and a plasminogen receptor. This effect was selective to t-PA and its close derivative tenecteplase. The truncated t-PA variant reteplase had a minor effect on permeability, whereas urokinase and desmoteplase were ineffective. t-PA also induced marked shape changes in both brain endothelial cells and astrocytes. Changes in astrocyte morphology coincided with increased F-actin staining intensity, larger focal adhesion size, and elevated levels of phosphorylated myosin. Inhibition of Rho kinase blocked these changes and reduced t-PA/plasminogen-mediated increase in permeability. Hence plasmin, generated on the cell surface selectively by t-PA, modulates the astrocytic cytoskeleton, leading to an increase in blood-brain barrier permeability. Blockade of the Rho/Rho kinase pathway may have beneficial consequences during thrombolytic therapy.
KATP channel opening and cardioprotection - the authors' response
Authors: M. J Shattock, M. Galinanes, D. J Hearse
Journal: Cardiovascular Research (1992)

Journal Article KATP channel opening and cardioprotection – the authors' response Get access Michael J Shattock, Michael J Shattock Cardiovascular Research, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, United Kingdom Search for other works by this author on: Oxford Academic PubMed Google Scholar Manuel Galiñanes, Manuel Galiñanes Cardiovascular Research, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, United Kingdom Search for other works by this author on: Oxford Academic PubMed Google Scholar David J Hearse David J Hearse Cardiovascular Research, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, United Kingdom Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 11, November 1992, Pages 1156–1157, https://doi.org/10.1093/cvr/26.11.1156a Published: 01 November 1992
EXPERIMENTAL LIVER NECROSIS; IV. NUCLEIN METABOLISMS
Authors: Holmes C. Jackson, Richard M. Pearce
Journal: The Journal of Experimental Medicine (1907)

In necrosis of the liver of the dog produced by haemotoxic immune sera, the increased excretion of uric acid, purin bases and inorganic phosphorus pentoxide is the result of the hydrolysis of nuclear material occurring during the autolysis of the necrotic tissue.
Naming the Days
Authors: Berwyn J. Moore
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibitory effect of spiradoline, a opioid receptor agonist, on Ca2+ induced contraction and the intracellular Ca2+ concentration in porcine coronary artery
Authors: Y. Harasawa, M. Kimura, S. Hayashi
Journal: Cardiovascular Research (1991)

The aim was to clarify the inhibitory effect of the selective kappa agonist, spiradoline, on coronary arterial smooth muscle in relation to the intracellular Ca2+ concentration.The inhibitory effect of spiradoline was investigated (1) on the contractile response of pig coronary artery to the readmission of Ca2+, following initial exposure to Ca2+ free medium and depolarisation with 40 mM K+; (2) on the intracellular Ca2+ concentration as assessed using the fluorescent calcium indicator fura-2. Relaxant responses to spiradoline in isolated porcine coronary artery strips contracted with K+ and prostaglandin F2 alpha were also examined.Coronary arteries isolated from pigs of both sexes were used. The right and left circumflex coronary arteries were cut into 3 mm wide strips which were used to measure the change in contractile force and the intracellular Ca2+ concentration.Prior treatment with spiradoline at 2 x 10(-6) mol.litre-1 or more inhibited the contractile response to the readmission of Ca2+ in porcine coronary artery exposed to Ca2+ free medium in the presence of high K+. Naloxone at 3 x 10(-4) mol.litre-1 did not reverse the inhibitory action of 2 x 10(-5) M spiradoline. Ca2+ induced contraction was inhibited completely by 10(-4) M spiradoline. Moreover, spiradoline caused relaxation in arterial preparations that had been contracted with K+ (15 to 25 mmol.litre-1) or prostaglandin F2 alpha (10(-6) to 3 x 10(-6) mol litre-1), greater relaxation being seen in the K+ induced contraction. The intracellular Ca2+ concentration was significantly lowered by 2 x 10(-5) M spiradoline.The relaxant response of coronary artery to spiradoline is, in part, attributable to interference with Ca2+ entry into the arterial smooth muscle.