tbuckley/cabot-search huggingface dataset:
Integrating Medical Plans Within Family Life
Authors: Jen Faultner
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Aberrant course of the left anterior descending coronary artery assoicated with anomalous left circumflex origin from the pulmonary artery.
Authors: B R Chaitman, M G Bourassa, J Lespérance, J L Dominguez, J Saltiel
Journal: Circulation (1975)

We have presented a two year nonoperative follow-up of an asymptomatic 14-year-old girl with an unusual anomaly of the coronary arteries. Systolic and diastolic murmurs heard preoperatively did not change following severance of a patent ductus arteriosus. Postoperative selective coronary arteriography revealed (1) anomalous orgin of the left anterior descending artery from the right aortic sinus of Valsalva crossing between the aorta and pulmonary artery, (2) aberrant circumflex artery orgin from the pulmonary artery and (3) collaterals from the left anterior descending and right coronary arteries to the circumflex artery. This combination of coronary anomalies has never been described previously.
A Systematic Analysis of Efficacy of Second-Line Chemotherapy in Sensitive and Refractory Small-Cell Lung Cancer
Authors: Taofeek K. Owonikoko, Madhusmita Behera, Zhengjia Chen, Chandar Bhimani, Walter J. Curran, Fadlo R. Khuri, Suresh S. Ramalingam
Journal: Journal of Thoracic Oncology (2012)

Small-cell lung cancer (SCLC) patients unresponsive or relapsing within 90 days after frontline chemotherapy have poor prognosis and are treated with regimens different from the first-line regimen. Potential differences in the efficacy of second-line therapy for refractory and sensitive SCLC have not been well studied.
Cytokines in Polymyalgia and Giant Cell Arteritis
Authors: Larry M. Greenbaum
Journal: Annals of Internal Medicine (1995)

Letters15 April 1995Cytokines in Polymyalgia and Giant Cell ArteritisLarry M. GreenbaumLarry M. GreenbaumSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-8-199504150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Weyand and colleagues [1] found that patients with polymyalgia rheumatica and giant cell arteritis have similar cytokine profiles. However, their patients with polymyalgia rheumatica may not be representative of most of these patients. Seventeen tissue samples from 9 different patients were available for analysis. It is unclear whether 17 different temporal artery biopsy specimens were taken from 9 patients or whether different fragments of the same biopsy specimen were analyzed separately for some patients. In most patients with polymyalgia rheumatica, bilateral temporal artery biopsy specimens are not usually analyzed. I wonder whether this group of patients with ...REFERENCE1. Weyand CM, Hicok KC, Hunder GG, Goronzy JJ. Tissue cytokine patterns in patients with polymyalgia rheumatica and giant cell arteritis. Ann Intern Med. 1994; 121:484-91. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1995Volume 122, Issue 8Page: 634KeywordsArteriesBiopsyCytokinesGiant cellsPatient advocacyPolymyalgia rheumatica Issue Published: 15 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Electrical Aversion Therapy
Authors: F. A. Whitlock
Journal: BMJ (1964)

might allow his fantasies to wander whilst submitting himself to electric shocks and thereby spread the conditioning process to include material that is unrelated to his sexual perversion.He must constantly choose between indulging a pleasurable perversion, irrespective of its attendant guilt feelings on the one hand, and subjecting himself to un- pleasant electric shocks to remove his symp- toms on the other hand.His motives for cure must never weaken.If they do relapse is certain.The personal side of the treatment is important also.The behaviour therapist should never attempt to treat a patient who does not wish to be cured, and must provide frequent encouragement to those who do.-I am, etc.,
Nitric oxide released from activated platelets inhibits platelet recruitment.
Authors: J E Freedman, J Loscalzo, M R Barnard, C Alpert, J F Keaney, A D Michelson
Journal: Journal of Clinical Investigation (1997)

Vessel injury and thrombus formation are the cause of most ischemic coronary syndromes and, in this setting, activated platelets stimulate platelet recruitment to the growing thrombus. Recently, a constitutive nitric oxide synthase (NOS) has been identified in human platelets. To further define the capacity of platelets to produce nitric oxide (NO), as well as to study the role of this NO in platelet recruitment, we adapted a NO-selective microelectrode for use in a standard platelet aggregometer, thereby permitting simultaneous measurement of platelet aggregation and NO production. Treatment of platelets with the NO synthase inhibitor -NG-nitroarginine methyl ester (L-NAME), reduced NO production by 92+/-8% in response to 5 microM ADP compared to control but increased aggregation by only 15+/-2%. In contrast, L-NAME had a more pronounced effect on platelet recruitment as evidenced by a 35+/-5% increase in the extent of aggregation, a 33+/-3% decrease in cyclic GMP content, and a 31+/-5% increase in serotonin release from a second recruitable population of platelets added to stimulated platelets at the peak of NO production. To study platelet recruitment accurately, we developed an assay that monitors two platelet populations simultaneously. Nonbiotinylated platelets were incubated with L-NAME or vehicle and activated with ADP. At peak NO production, biotinylated platelets were added. As measured by three-color flow cytometry, there was a 56+/-11% increase in the number of P selectin- positive platelets in the nonbiotinylated population treated with L-NAME as compared to control. When biotinylated platelets were added to the L-NAME-treated nonbiotinylated population, the number of P selectin positive biotinylated plate-lets increased by 180+/-32% as compared to biotinylated platelets added to the control. In summary, stimulated platelets produce NO that modestly inhibits platelet activation but markedly inhibits additional platelet recruitment. These data suggest that platelet-derived NO may regulate platelet recruitment to a growing thrombus.
Ki-Lymphoma and Interleukin-6
Authors: Ichiro Kubonishi
Journal: Annals of Internal Medicine (1998)

Letters15 March 1998Ki-Lymphoma and Interleukin-6Ichiro Kubonishi, MD, Hisanori Machida, MD, and Isao Miyoshi, MDIchiro Kubonishi, MDKochi Medical School; Kochi 783, JapanSearch for more papers by this author, Hisanori Machida, MDKochi Medical School; Kochi 783, JapanSearch for more papers by this author, and Isao Miyoshi, MDKochi Medical School; Kochi 783, JapanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-6-199803150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Preti and colleagues report that the serum interleukin-6 level is closely correlated with prognosis in patients with diffuse large-cell lymphoma [1]. We are intrigued by this report because we recently encountered two patients with Ki-1 (CD30) antigen-positive lymphoma (Ki-1 lymphoma) who had high serum interleukin-6 levels (180 pg/mL and 202 pg/mL; normal < 4 pg/mL) and an aggressive clinical course. Ki-1 lymphoma is a new disease recognized by its distinct morphologic features and reactivity to a monoclonal antibody to the Ki-1 molecule [2, 3]. It is classified as an anaplastic large-cell lymphoma in the revised European-American classification ...References1. Preti HA, Cabanillas F, Talpaz M, Tucker SL, Seymour JF, Kurzrock R. Prognostic value of serum interleukin-6 in diffuse large-cell lymphoma. Ann Intern Med. 1997; 127:186-94. Google Scholar2. Stein H, Mason DY, Gerdes J, O'Connor N, Wainscoat J, Pallesen G, et al. The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985; 66:848-58. Google Scholar3. Filippa DA, Ladanyi M, Wollner N, Straus DJ, O'Brien JP, Portlock C, et al. CD30 (Ki-1)-positive malignant lymphomas: clinical, immunophenotypic, histologic, and genetic characteristics and differences with Hodgkin's disease. Blood. 1996; 87:2905-17. Google Scholar4. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood. 1994; 84:1361-92. Google Scholar5. Kubonishi I, Bandobashi K, Murata N, Daibata M, Ido E, Sonobe H, et al. High serum levels of CA125 and interleukin-6 in a patient with Ki-1 lymphoma. Br J Haematol. 1997; 98:450-2. Google Scholar Author, Article, and Disclosure InformationAffiliations: Kochi Medical School; Kochi 783, Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1998Volume 128, Issue 6Page: 506KeywordsCellsCombination chemotherapyCyclophosphamideDiffuse large B-cell lymphomaLymphomaMessenger RNAMetastasisMonoclonal antibodiesPhenotypesPolymerase chain reaction Issue Published: 15 March 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Electrocuted Horse—Post-Mortem Examination.
Authors: J. J. Conner
Journal: JAMA (1894)

Pana, Ill., Dec. 14, 1894. <h3>To the Editor:</h3> —I send you herewith some printed notes of the<i>post-mortem</i>appearance of a horse killed by electricity. As the subject of whether or not a man can be killed by electricity is agitating the public mind through the press at present, I thought perhaps this incident might be of general interest. In looking up the literature of the subject, I find scarcely any mention made of the<i>post-mortem</i>appearance of a body killed by electricity. In the<i>Annual of the Universal Medical Sciences</i>for 1891, Vol. v., Section C, page 30, Dr. Rockwell says: "The reported autopsies on patients killed by currents of high potentials are few. In such the blood is usually fluid; the viscera are congested; small hemorrhages are frequent. Peterson thinks there are no pathognomonic signs of death by electricity, but that it divides and disarranges the fine molecular
First Results from the “Patient's Anastrozole Compliance to Therapy Programme” (PACT) Evaluating the Impact of a Standardized Information Service on Compliance in Postmenopausal Women with Early Breast Cancer (EBC) Receiving Adjuvant Endocrine Therapy.
Authors: N. Harbeck, C. Hackisch, M. Blettner, H. Lück, P. Hadji, R. Landthaler, R. Martin, D. Schmitt, H. Schulte, A. Rexrodt von Fircks, R. Haidinger, D. Jäger, S. Zaun, R. Kreienberg
Journal: Cancer Research (2009)

Abstract Background: In adjuvant treatment of hormone-responsive breast cancer, existing data document that 23% and 50% of patients were non-compliant after the first and fourth year of tamoxifen (TAM) therapy, respectively. Here, we present the PACT-study that aims to increase awareness, motivation and adherence to oral hormonal therapy, namely the aromatase inhibitor anastrozole, in routine clinical practice by simple interventions such as written standardized mailings and reminder services.Materials and Methods: In this two arm, parallel group trial with a primary duration of 12 months and 60 months follow-up, women with hormone receptor positive EBC receiving anastrozole once daily were randomized to either routine clinical care alone or to receiving additional standardized information for the first 12 months of adjuvant therapy. Primary endpoint is compliance rate in the standard versus intervention arm after 12 months, where compliance is defined by an 80% intake of the total medication. Secondary endpoints include persistence on therapy, reasons for non-compliance, influence of baseline characteristics, and of compliance on clinical outcome parameters.Compliance was evaluated by self report using standardized, detailed questionnaires at baseline and after each year of treatment. In addition, the prescription data for each patient from hospital records and physician recall was collected. Finally, quality of life and patient satisfaction were assessed using standardized questionnaires.Results: From July 2006 until November 2008, 4.924 women were enrolled with a median patient age of 64 years. Besides demographic data and patient characteristics results of patient's self reporting data will be shown for the first time at this meeting.Conclusion: PACT is the largest prospective investigation on compliance regarding an aromatase inhibitor as adjuvant therapy so far. The programme's goals are to clarify what aspects influence patients' adherence to prescribed medication and how motivation for regular intake can be accomplished. Furthermore, PACT seeks to prove if a simple intervention such as a standardized information and reminder services throughout the first year of treatment may improve compliance and thus eventually influence treatment outcomes. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6079.
Percutaneous Transluminal Angioplasty of the Renal Arteries
Authors: David C. Levin
Journal: JAMA (1984)

Percutaneous transluminal angioplasty (PTA) of renal artery stenosis has proved highly efficacious, particularly in patients with lateralizing renal vein renin ratios, fibromuscular dysplasia, and atherosclerotic lesions confined to one renal artery without involvement of the aortic wall surrounding the renal ostium. In some series, a moderate recurrence rate has been reported, but these recurrences usually respond well to redilatation. Complications are relatively rare and generally not serious. Early results compare favorably with those of large surgical series. Some of the disparities in published results of renal PTA may be accounted for by differences in technique. Important advances in both equipment and PTA technique have occurred since the procedure was introduced in 1978; these may prove to favorably affect the long-term results. (<i>JAMA</i>1984;251:759-763)
Abstract 2543: Circulating s100a9 myeloid-derived suppressor cells are predictive for poor pfs in patients with egfr mutation positive lung adenocarcinoma treated with gefitinib
Authors: Po-Hao Feng, Chih-Teng Yu, Kang-Yun Lee
Journal: Cancer Research (2014)

Abstract Introduction: Around 10-30% of patients with EGFR-mutation positive lung adenocarcinoma do not have objective response to EGFR-TKI, whilst the majority of the EGFR-mutation positive patients eventually develop acquired resistance. We have recently demonstrated that the distinct S100A9+ myeloid derived suppressor cells (MDSC) predicted poor outcome in response to cisplatin-based chemotherapy in patients with advanced NSCLC. In this study, we tested whether numbers of circulating S100A9+ MDSC, among other potential factors, could be a predictor for treatment response to EGFR-TKI. Methods: Between 2010-2012, thirty-four patients with pathologically proved, stage IIIB-IV lung adenocarcinoma with sensitizing EGFR-mutations, were prospectively enrolled. Gefitinib was used as the first line treatment. Pretreatment S100A9 MDSC was determined by FACS analysis and serum HGF by ELISA. Results: Among the patients, 47.1% (16/34) had Ex19Del and 50.0% (17/34) had L858R mutations. The objective response rate was 84.4% and the median progression-free survival (PFS) 10.16 months (95% CI 8.18-12.14 months). In univariate analysis, body weight loss, brain metastasis and S100A9 MDSC (p = 0.008, 0.022 and 0.014, respectively), but not gender, smoking, type of EGFR mutation, or serum HGF, were significant factors for PFS. Multivariate Cox regression analysis revealed brain metastasis (HR=3.924, 95% CI 1.449-10.627, p=0.007) and S100A9+ MDSC (HR=4.944, 95% CI 1.578-15.490, p=0.006) were both independent factors for PFS. When the medium number of S100A9 MDSC, e.g. 17.9% of the PBMC, was chosen as a cut off level, patients with high MDSC had shorter PFS compared with those with low MDSC (median 7.2 months (95% CI, 5.5-8.9 months) vs. 12.7 months (95% CI, 8.1-17.2 months), respectively, p=0.014 by Log-Rank Test). Conclusions: Pretreatment S100A9+ MDSC and brain metastasis are independent predictors for shorter PFS to EGFR TKI in EGFR-mutation positive patients. This MDSC might potentially play some roles in treatment response to EGFR-TKI. Keyword: NSCLC, S100A9+ MDSC, EGFR mutation, EGFR-TKI Citation Format: Po-Hao Feng, Chih-Teng Yu, Kang-Yun Lee. Circulating s100a9 myeloid-derived suppressor cells are predictive for poor pfs in patients with egfr mutation positive lung adenocarcinoma treated with gefitinib. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2543. doi:10.1158/1538-7445.AM2014-2543
BACTERIUM GRANULOSIS IN RELATION TO TRACHOMA: ITS RECOVERY FROM EXPERIMENTALLY INFECTED MONKEYS AND FROM HUMAN TRACHOMA
Authors: E. B. Tilden, J. R. Tyler
Journal: The Journal of Experimental Medicine (1930)

One of the strains of Bacterium granulosis isolated by Noguchi in 1926 has been maintained in culture and in monkeys and continues to be capable, after 3 years, of inducing a chronic granular conjunctivitis in monkeys. Cultures of this strain have been recovered from the monkey lesions as late as 3 years after inoculation and have been shown to reproduce the granular disease in monkeys. Six additional strains of Bacterium granulosis have been isolated from cases of trachoma occurring in the Indian schools of Arizona. The cultures thus obtained are identical morphologically and culturally with those isolated by Noguchi and have induced the same chronic granular conjunctivitis in monkeys. Advanced untreated cases are more favorable for cultural study than treated cases. Cultures of Bacterium granulosis kept on semisolid medium containing 10 per cent rabbit serum ("leptospira medium") remain viable for many months at room temperature, and sealed ampoules of such cultures have been found to retain their pathogenicity for the monkey conjunctiva for at least 69 days at room temperature and at least 284 days at 4° to 6°C. Several additional cultural and biological characteristics of Bacterium granulosis have been described. Of outstanding importance is the fact that cocaine, in contradistinction to novocain, has a bactericidal effect on the organism. This fact, in view of the common use of cocaine for anesthesia, may explain the negative results of cultivation experiments reported by some workers.
After-History of Pneumonia the Guide to its Treatment
Authors: A. Jamison
Journal: BMJ (1888)

188&and a piece of bread is a suifficient meal in itself, and should be available for nothing to eyery man who applies for it.The soup can be made from the large bones of the rations; the sale of the refuse will generally be found to cover the cost of the vegetables, split peas, and flour reqxuired to complete the soup.This -has been adopted in some regiments, and it is found that the applicants for the soup are usually those w-hose finances are low, and on the days immediately before the pay-day, there is often a difficulty in supplying the numbers.There is natuirally a greater demanrd in the winter.The universal adoption of this plan cannot be too strongly recommended.Afew words as to the times spirit rations should be issued;they are best taken with meals-at dinniier time preferably, never before.This is not the place to discuss the merits or the action of alcohol; in small quantities it increases the secretion of the gastric juice and the movements of the stomach, and thus aids digestion.Alcohol shouiltl be taken, largely diluted with water, with, or rather at the close of, a meal.In Quieen's Regulations, Sect.xv, Para. 103,it is laid down that malt liquor may be taken from the canteen to the barrack rooms for the men's consumption at dinner; this privilege is, however, not acknowledged by all commanding officers andl its observance should be universally in- sisted on.
Anger management: bacteria soothe the savage host
Authors: Patrick C. Seed
Journal: Journal of Clinical Investigation (2013)

A 5-year-old girl has come to you a week after completing a course of antibiotics for a febrile urinary tract infection (UTI). She now seems well and energetic. A urinalysis is now clear without traces of inflammation, including an absence of protein, blood, leukocyte esterase, and nitrites. Her urine is submitted for a test of cure and comes back positive, with over 100,000 colonies per milliliter of E. coli, the same kind of bacteria that was cultured from her urine when she was symptomatic with the UTI. Perplexed, her mother asks how her child can have bacteria once again in her bladder but not be symptomatic and asks if antibiotics are again necessary.
Noninvasive quantitation of regional myocardial oxygen consumption in vivo with [1-11C]acetate and dynamic positron emission tomography.
Authors: D B Buxton, C A Nienaber, A Luxen, O Ratib, H Hansen, M E Phelps, H R Schelbert
Journal: Circulation (1989)

The usefulness of [1-11C]acetate as a tracer of overall myocardial oxidative metabolism for use with positron emission tomography has been investigated in 12 closed-chest dogs. Myocardial 11C activity clearance kinetics after intravenous administration of [1-11C]acetate in dogs have been determined noninvasively by positron emission tomography. Biexponential fitting of regional myocardial 11C time-activity curves was performed to give clearance half-times and fractional distribution. The rate constant k1 for the early rapid phase of 11C activity clearance was found to correlate linearly with myocardial oxygen consumption (y = 0.0156x + 0.039; SEE = 0.023; r = 0.95). k1 was approximately 7% lower in septal sectors compared with the left ventricular free wall, suggesting that regional oxygen consumption in the septum was lower; a concomitant regional attenuation of blood flow in the septum relative to the left ventricular free wall was also observed. In dogs using carbohydrates as the predominant fuel, k1 oxygen consumption was somewhat more than in dogs using predominantly free fatty acids (0.021 +/- 0.002 compared with 0.018 +/- 0.002, p less than 0.01), indicating that increased carbohydrate consumption is associated with a small increase in k1 at constant oxygen consumption. It is concluded that measurement of myocardial [1-11C]acetate kinetics allows noninvasive determination of cardiac oxygen consumption by positron emission tomography and that the technique is relatively insensitive to myocardial fuel selection.