tbuckley/cabot-search huggingface dataset:
Kathleen Murray Hadden (née Morrison)
Authors: Hilary Hinton
Journal: BMJ (2006)

served in the Royal Army Medical Corps in Normandy, Belgium, and Rhodesia before joining his brother in general practice in Bellshill in industrial Lanarkshire.After retirement in 1978 he did locum work.He was chairman of Lanarkshire Medical Committee for 12 years.In addition to an avid interest in politics, sport, crosswords, and puddings, he supplied family, friends and neighbours with plants annually, and grew show chrysanthemums, winning many prizes locally and nationally.He was chairman of the Scottish Chrysanthemum and Dahlia Society for many years.David survived cancer three times.
Strongyloidiasis in US Veterans of the Vietnam and Other Wars
Authors: Robert M. Genta, Robert Weesner, Richard W. Douce, Theresa Huitger-O'Connor, Peter D. Walzer
Journal: JAMA (1987)

The prevalence of strongyloidiasis among American veterans of the Vietnam and other wars was evaluated by testing several groups of veterans for serum IgG antibodies against Strongyloides stercoralis antigens, using an enzyme-linked immunosorbent assay. Of 493 Vietnam veterans, eight (1.6%) were seropositive. Of 60 patients with abdominal symptoms and/or elevated eosinophilia (greater than 0.08 [greater than 8%]) admitted to the Cincinnati Veterans Administration Medical Center, 12 (5%) were seropositive. Of 147 residents of a Veterans Administration-operated nursing home, six (4%) were seropositive. All infected patients in the latter two groups were World War II veterans. The usefulness of the enzyme-linked immunosorbent assay as a screening tool for at-risk groups is suggested by the finding that S stercoralis larvae were demonstrated in most seropositive patients when a sufficient number of fresh stools were examined.
Self-poisoning: management of patients in Nottingham, 1976.
Authors: D R Blake, J R Mitchell
Journal: BMJ (1978)

Analysis of the management of a sample of patients with drug overdoses in Nottingham in 1976 showed that some 10% of the patients who arrived in the casualty department after an overdose were neither admitted nor seen by a psychiatrist. Of the patients who were admitted to medical wards for psychiatric evaluation, 31% were thought to need no further psychiatric action while the default-rate in those who were referred to a psychiatric outpatient clinic was 43%. Both these endpoints showed considerable variations among the 10 psychiatric teams, but of every 100 patients with drug overdose who arrived in the casualty department, 51 left hospital without continuing psychiatric or social action having been taken. As the recommendations of the Hill Committee are not being implemented we suggest that they should be critically re-examined and that the indication for, and value of, psychiatric intervention should be determined.
New Guidelines to Avoid TB Transmission Issued
Authors: Charles Marwick
Journal: JAMA (1994)

NEW EFFORTS to protect physicians and other health care workers from acquiring tuberculosis (TB) from their patients are being made by the Centers for Disease Control and Prevention (CDC), Atlanta, Ga. The agency has just issued updated guidelines for the use of hospitals and clinics that treat patients with TB and has taken steps that should result in workers having improved respirators to use when they are exposed to patients with the disease in its infectious form. At the same time, a new analysis of the effectiveness of the existing recommendations for the control of TB transmission shows that putting them into practice can indeed prevent transmission in hospitals and other health care facilities. The new guidelines replace those issued in 1990. "They provide a lot more information for health care workers about preventing transmission of TB," says Samuel W. Dooley, MD, acting associate director for science in the CDC's
Family (Parental) History and Prevalence of Hypertension
Authors: Rose Stamler, Jeremiah Stamler, Wallace F. Riedlinger, George Algera, Richard H. Roberts
Journal: JAMA (1979)

In a nationwide screening program, blood pressure measurements, family (parental) histories of hypertension, and self-evaluations of weight class were obtained for more than a half million people. Positive family history was associated with hypertension prevalence double that found in persons with negative history and was independent of weight. When overweight was also present, however, hypertension prevalence was three to four times as high. Hypertension was more likely to have been previously diagnosed in screenees if family history was positive. However, such screenees did not have a higher proportion receiving effective treatment than those with negative family history. When an index case of hypertension is found, other family members should be examined. For persons with positive family history, nutritional-hygienic recommendations to avoid overweight may be important in reducing the risk of becoming hypertensive.
994 VISCERAL FAT AND INSULIN RESISTANCE ARE INDEPENDENTLY CORRELATED TO DEGREE OF LIVER STEATOSIS AND STAGE OF FIBROSIS IN A NON-SELECTIVE COHORT OF OBESE PATIENTS
Authors: S. Francque, A. Verrijken, I. Mertens, G. Hubens, E. Van Marck, P. Pelckmans, L. Van Gaal, P. Michielsen
Journal: Journal of Hepatology (2009)
THE USE OF LIVER EXTRACT INTRAVENOUSLY IN THE TREATMENT OF PERNICIOUS ANEMIA
Authors: RAPHAEL ISAACS
Journal: JAMA (1933)

Following the demonstration in 1928 by Beckmann<sup>1</sup>and in 1929 by Cohn, McMeekin and Minot<sup>2</sup>that liver extract could be given intravenously to patients with pernicious anemia with good therapeutic results, numerous forms of the material have been used with success. The first published formula of a simply prepared product was that of Castle and Taylor<sup>3</sup>in 1931. Their solution consisted essentially of liver extract No. 343 N. N. R. washed with ether and dissolved in physiologic solution of sodium chloride. A later modification (Strauss, Taylor and Castle<sup>4</sup>) was made by using an aqueous solution at a<i>p</i>hof 7.4. Intensive studies of the blood changes following the intravenous use of Castle and Taylor's solution were made in our laboratories in May, 1931, and were reported in November, 1931.<sup>5</sup>As the reactions following this treatment were too severe to make the medicine of routine
FDA, US Hospital and Pharmacy Groups Report Drug Shortages a Growing Problem
Authors: M. Mitka
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prolapse of a cervical disc in elderly patients with cervical spondylosis.
Authors: S Young, L Tamas, S A O'Laoire
Journal: BMJ (1986)

Une observation: femme de 82 ans presentant depuis 6 semaines d'abord des douleurs au niveau du cou, puis des troubles moteurs au niveau des mains, puis une faiblesse progressive des membres inferieurs. Un prolapsus du disque intervertebral C3/C4 est diagnostique par myelographie. Une dissectomie sans fusion donne d'excellents resultats
Hepatic effects of a phthalate ester plasticizer leached from poly(vinyl chloride) blood bags following transfusion.
Authors: S V Kevy, M S Jacobson
Journal: Environmental Health Perspectives (1982)

The effects of di(2-ethylhexyl) phthalate (DEHP) on hepatic function and histology were evaluated in the rhesus monkey undergoing platelet and plasma transfusion. The average cumulative amount infused in one year is comparable to that received by patients who undergo chronic transfusion. Abnormalities in hepatic scan and BSP kinetics persisted for up to 26 months after transfusion, as did histologic abnormalities. Patients undergoing maintenance hemodialysis receive a yearly dose of DEHP which is 10-20 times that which produced hepatotoxicity in the transfused rhesus.
What’s New With Measuring Cholesterol?
Authors: J. Michael Gaziano, Thomas A. Gaziano
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterization of Metastatic Breast Cancer Patients with Non-Detectable Circulating Tumor Cells.
Authors: M. Mego, M. Mego, M. Mego, S. Dawood, U. De Giorgi, U. De Giorgi, V. Valero, E. Andreoupolou, B. Handy, N. Ueno, J. Reuben, M. Cristofanilli
Journal: Cancer Research (2009)

Abstract Background: Circulating tumor cells (CTC) are independent predictor of progression free and overall survival in metastatic breast cancer patients, with superior prognosis for patients with CTC &amp;lt;5 per 7.5mL of peripheral blood. However, 30-50% of patients have non-detectable CTC. The aim of this study was to assess the prognostic factors in MBC patients with non-detectable CTC.Methods: This retrospective study included 271 MBC patients evaluated between January 2004 and December 2007. Median age of patients was 56 years (range: 23-82 years). CTCs were enumerated before patients started a new line of treatment using the CellSearchTM. Overall survival (OS) was calculated from the date of CTC measurement, estimated by the Kaplan-Meier product limit method, and compared between groups with the log-rank test.Results: Median CTC count was 2 (range: 0-1780) per 7.5 mL. CTCs were not detected in 99 (36.5%) patients, while 112 (41.3%) patients had CTC ≥ 5. Median OS for patients with 0 CTC; 1-4 CTC and ≥ 5 CTC was 29.3; 26.4; and 19.4 months (p = 0.04), respectively. Patients with brain metastasis have the highest probability of non-detectable CTC (71.4% vs. 33.6%; p = 0.001), while patients with bone metastasis are more likely to have CTC ≥ 1 (48.2% vs. 31.8%; p = 0.01). There was no association between other tumor characteristics (ER, PR, HER2, number and localization of tumor metastasis) and non-detectable CTC status. Patients with CTC = 0 have non-significantly better OS compared to patients with CTC ≥ 1 (29.3 vs. 23.3 months; p = 0.09) and have superior survival in all but one analyzed subgroups; only inflammatory breast cancer (IBC) patients with CTC = 0 have inferior OS compared with patients with CTC ≥ 1 (26 vs. 37 months; p = 0.67). In a subgroup of patients with non-detectable CTC, triple negative MBC has the poorest survival (median OS = 18.8 months), while hormone receptor positive MBC, without visceral metastases and non-inflammatory breast cancer has the best survival (median OS = 36.9 months). In multivariate analysis, hormone receptor status and line of therapy were only independent prognostic factors for OS in patients with non-detectable CTC (Table 1).Conclusion: Patients with non-detectable CTC before start of new line of therapy comprise a heterogeneous group of patients with substantially different prognosis. Triple negative and IBC patients represent poor prognosis subgroups. These data suggest heterogeneity of microscopic disease in advanced cancer and indicate the need to investigate combining additional detection technologies. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3006.
Complications of Regional Anesthesia Peripheral Nerve Blocks on DVD: Upper Limbs and Lower Limbs
Authors: Alex Macario
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterization of three abnormal factor IX variants (Bm Lake Elsinore, Long Beach, and Los Angeles) of hemophilia-B. Evidence for defects affecting the latent catalytic site.
Authors: P Usharani, B J Warn-Cramer, C K Kasper, S P Bajaj
Journal: Journal of Clinical Investigation (1985)

Abnormal factor IX variant proteins were isolated from the plasmas of three unrelated severe hemophilia-B families that had been previously shown to contain functionally impaired molecules immunologically similar to normal factor IX. The families studied were: (1) a patient with markedly prolonged ox brain prothrombin time, designated factor IX Bm Lake Elsinore (IXBmLE); (b) three patients (brothers) with moderately prolonged ox brain prothrombin time, designated factor IX Long Beach (IXLB); and (c) a patient with normal ox brain prothrombin time designated factor IX Los Angeles (IXLA). Each variant molecule comigrates with normal factor IX (IXN) both in the sodium dodecyl sulfate and in the nondenaturing alkaline gel electrophoresis. All three variant proteins are indistinguishable from IXN in their amino acid compositions, isoelectric points, carbohydrate distributions and number of gamma-carboxyglutamic acid residues. Each variant protein undergoes a similar pattern of cleavage by factor XIa/Ca2+ and by factor VIIa/Ca2+/tissue factor, and is activated at a rate similar to that observed for IXN. All of the three variant proteins also react with an anti-IXN monoclonal antibody that interferes with the binding of activated IXN(IXaN) to thrombin-treated factor VIIIC. However, in contrast to IXaN, the cleaved IXBmLE has negligible activity (approximately 0.2%), and cleaved forms of IXLA and IXLB have significantly reduced activity (approximately 5-6%) in binding to antithrombin-III/heparin, and in activating factor VII (plus Ca2+ and phospholipid) or factor X (plus Ca2+ and phospholipid) +/- factor VIII. These data, taken together, strongly indicate that the defect in these three variant proteins resides near or within the latent catalytic site. This results in virtually a complete loss of catalytic activity of the cleaved IXBmLE molecule and approximately 95% loss of catalytic activity of the cleaved IXLA and IXLB molecules.
Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR
Authors: F Lin, C M Noyer, Q Ye, J Courvalin, H J Worman
Journal: Hepatology (1996)

Autoantibodies from rare patients with primary biliary cirrhosis (PBC) recognize LBR, or lamin B receptor, an integral membrane protein of the inner nuclear membrane. Human LBR has a nucleoplasmic, amino-terminal domain of 208 amino acids followed by a carboxyl-terminal domain with eight putative transmembrane segments. Autoantibodies against LBR from four patients with PBC recognized the nucleoplasmic, amino-terminal domain but not the carboxyl-terminal domain. Immunoblotting of smaller fusion proteins demonstrated that these autoantibodies recognized a conformational epitope(s) contained within the stretch of amino acids from 1 to 60. These results, combined with those of previous studies, show that autoepitopes of nuclear membrane proteins are located within their nucleocytoplasmic domains and that autoantibodies from patients with PBC predominantly react with one domain of a protein antigen. This work also provides further characterization of anti-LBR antibodies that have found utility as reagents in cell biology research.
Acute Immunologic Arthritis in Rabbits
Authors: Claude V. Deshazo, Peter M. Henson, Charles G. Cochrane
Journal: Journal of Clinical Investigation (1972)

Mediators of acute immunologic injury have been studied in vivo by producing arthritis in rabbit knee joints. A reversed passive Arthus lesion was produced by injecting antibody into the joint space and antigen intravenously. Injury was assessed by measuring leakage of serum proteins and circulating radiolabeled proteins into the joint space and by the accumulation of neutrophils in the joint fluid. Inflammatory exudate was recovered for study by a standardized irrigation technique.Maximal vascular permeability developed 2 hr after injection as neutrophils accumulated about immune complexes in venule walls to produce structural injury. After 5 hr the number of neutrophils in the joint space rose rapidly, followed by a second rise in permeability at 8 hr. Neutrophil depletion abolished both peaks of permeability. It was then possible to reconstitute the synovial lesion in neutrophil-depleted rabbits by intra-articular injection of purified suspensions of neutrophils.A requirement for complement was demonstrated in development of the lesion. Rabbits genetically deficient in C6 showed delay in vascular permeability, appearance of neutrophils, and histologic lesions. The delay was longer in normal rabbits depleted of C3. In C6-deficient rabbits depleted of C3, still further reduction in injury occurred. Evidence was obtained as well for a chemotactic attraction of neutrophils in vivo. Antigen-antibody-complement complexes in the walls of blood vessels attracted neutrophils placed in the joint space of neutrophil-depleted rabbits. Omission of either antigen or antibody from this replacement reaction prevented the migration of neutrophils.
CAMPHOR-MENTHOL; A SUPPLEMENTARY REPORT.
Authors: SETH SCOTT BISHOP
Journal: JAMA (1895)

Since the introduction of this remedy at the meeting of the Mississippi Valley Medical Association in 1891, and published in theJournal, it has come into quite general use for catarrhal conditions of the upper respiratory tract. But inquiries have not ceased to come from various parts of the country concerning the method of its application, and for the details of my experience with it since. The purpose of these notes is to answer such questions. Although I did not recommend its use until long after I had discovered that the union of these two camphors resulted in a fluid of the chemic formula C<sub>10</sub>H<sub>18</sub>O, and after I had satisfied myself that we possessed a valuable remedy in this new drug, I am now able to express greater confidence, and to verify my former statements by the experience of others, as well as by my daily
INCREASED PULSE WAVE VELOCITY MEASURED BY COMPUTED TOMOGRAPHY IS ASSOCIATED WITH CORONARY ATHEROSCLEROSIS, AND MORTALITY
Authors: Naser Ahmadi, Fereshteh Hajsadeghi, Vahid Nabavi Larijani, John Sanchez, Michael Baskett, Andrew Choi, Ferdinand Flores, Matthew Budoff
Journal: Journal of the American College of Cardiology (2012)
Spectrum of pathogens in acute cholangitis in patients with and without biliary endoprosthesis
Authors: Andreas Weber, Jochen Schneider, Stefan Wagenpfeil, Philipp Winkle, Julia Riedel, Nina Wantia, Susanne Feihl, Franziska Römmler, Dorothee M. Baur, Roland M. Schmid, Hana Algül, Wolfgang Huber
Journal: Journal of Infection (2013)
A NOTE ON A SYMPTOMATIC TREATMENT OF ASTHMA
Authors: A. T. Todd
Journal: BMJ (1929)

CONCLUSIONS.1. Ephedrinie hhas a definiite beneficial effect oni moderate attacks of asthma, tlieir iiinumber and severity being diminiislhed( or1 even comp)letely aborted.2. It hlas n1o effect oni severe attacks of eithier simple or complicated asthma.3. Its effect in pertussis is to relieve the violeint couIgh1, thie wlhoop, and vomiting, in mild or moderate cases.In severe cases there is nio effect at all.The progress of the infection is not influ-ienced, tlhe relief beinig limite(d to tlhe mechlanical factor.4. Ephedrine appears to act by relieving the local spasm in the broncho-constrictors.This spasm is l)rodut(edl by the irritan1t effect of the tough mu1cUIs on tb-nt1mcous memnbraine, made hypersensitive by the toxins of 1?.pei tissis.By relief of this spasm the irritant mucus can be removed withoult tliviolent expiratory efforts or cou-rhs whicih are usually necessary.The paroxysms are thlus mafle shorter and less severe, and hence in favourable cases tlhe whooping anild vomitinlg disappear.Belladoinna paral yses the broncho- constrictors, and thsus aidls the ac-tionl of ej)hedrine, 'vhich stimulates the broncho-dilators.If belladonna be given with &phedriine it is necessary to antagonize the " drying effect on the secretion " of tlhe former (1ug by giving an expectorant.In bringing abouit this effect ephedrine in nio way influences the coIIrse of the infection, butt simply relieves the imiechanical difficulty of removinig the secretion and heniece-minlimizes the exihatustitng efforts on the part of thce child.-[Since this article was written a furthter 10 Cases of asthma and 15 cases of pertussis have-heen treated with ephedrine.Sinilar results were obtained to those described.]I am indebted to Dr. Jewsbury for permission to publisli my results on many of the cases.