tbuckley/cabot-search huggingface dataset:
THE VALUE OF LATERAL VIEWS OF THE THORAX
Authors: SAMUEL BROWN
Journal: JAMA (1928)

The lateral view of the thorax is but seldom used among roentgenologists in the study of the thoracic contents. This, we believe, is due to the assumption that stereoscopy of the usual anteroposterior views of the thorax is sufficient to enable one to recognize any existing change in the lungs, pleurae or mediastina. This assumption may be true in theory, but on practical application we find that the usual stereoscopic views of the thorax do not always reveal every change in the lungs, pleurae or mediastina, and when revealed, the exact location and nature cannot always be determined with a high degree of accuracy.  Keeping in mind the value of lateral views of the extremities, spine and heart, we adopted the same method in the study of the thoracic contents. During the past two years, several hundred chests were examined in the anteroposterior and lateral positions. The information obtained has
Abstract LB-45: Cancerous inhibitor of phosphatase PP2A in lung cancer
Authors: Guangbiao Zhou, Liang Ma, Zhesheng Wen
Journal: Cancer Research (2010)

Abstract Cellular signaling networks are controlled by reversible covalent phosphorylation, which depends on a precise balance between protein kinase and phosphatase activities. Recently, phosphatase has been shown to be silenced by cancerous inhibitor of phosphatase, leading to perturbation of the kinase/phosphatase balance. Here we report that at mRNA and protein levels, the expression of the cancerous inhibitor of phosphatase PP2A (CIP2A) were undetectable or very low in paratumor tissues, but was dramatically elevated in tumor samples in 33 (63.%) out of 52 patients. CIP2A enhanced clonogenic activity of human embryo lung fibroblast, while CIP2A silencing by siRNA led to inhibition of cell proliferation and induction of apoptosis of lung cancer cells. We found that LTZ010 which was a compound extracted from a traditional Chinese medicinal herb, triggered a rapid turnover of CIP2A, and increased PP2A phosphatase activity. At presence of proteasome inhibitor PS-341, aggresome was found in cytoplasm of cells treated with LTZ010, and catabolism of CIP2A was abrogated. We found that LTZ010 inhibited proliferation and cell growth of lung cancer cells, and activated caspase-9 and -8. Intriguingly, LTZ010 significantly inhibited tumor growth in vivo, but did not caused animal body weight loss. Our data suggest that CIP2A might play an important role in lung cancer tumorigenesis, and LTZ010 might have potential benefits for patients with lung cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-45.
Abstract 1017: Id-1 gene and protein as therapeutic target for head and neck squamous cell carcinoma
Authors: Ryuichi Murase, Sean McAllister, Yohei Fujita, Tomoki Sumida, Koichi Nakashiro, Pierre Desprez, Hiroyuki Hamakawa
Journal: Cancer Research (2014)

Abstract Squamous cell carcinoma is one of the most common malignancies in head and neck region. Primary tumors, especially derived from undifferentiated cells, tend to have aggressive phenotypes, which are mainly characterized by local recurrence and distant metastasis. In this study we found that Id-1, a negative regulator of tissue specific transcription factors, is highly expressed in head and neck squamous carcinoma cells (HNSCC), and that the expression is correlated with the malignant phenotype, i.e., cell proliferation and invasion. Id-1 knockdown dramatically reduces squamous cell invasion that is accompanied by profound morphologic changes and robust reduction in expression levels of mesenchymal markers.In addition, reduction in tumor growth and neoangiogenesis were observed in vivo, indicating that knock-down of Id-1 drastically suppresses VEGFA expression. Our results also suggested that VEGFA-autocrine loop activates tylosine kinase pathways including Srk and FAK, and therefore manifests invasive phenotype. With clinical materials obtained from HNSCC patients, significant correlation was observed between Id-1 and VEGFA. Furthermore, we demonstrated that a non toxic compound, cannabidiol, significantly downregulates Id-1 gene expression and associated squamous cell proliferation and invasiveness. Taken together, these results suggest that Id-1 controls cancer cell phenotype in culture and in vivo, and that drugs targeting Id-1 represent a novel and promising strategy for improving the therapy and outcome of patients with HNSCC. Citation Format: Ryuichi Murase, Sean McAllister, Yohei Fujita, Tomoki Sumida, Koichi Nakashiro, Pierre Desprez, Hiroyuki Hamakawa. Id-1 gene and protein as therapeutic target for head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1017. doi:10.1158/1538-7445.AM2014-1017
EFFICACY OF DIRECT STENTING WITHOUT PREDILATION DURING PERCUTANEOUS CORONARY INTERVENTION IN ACUTE MYOCARDIAL INFARCTION- A RANDOMIZED TRIAL EVALUATING MICROVASCULAR DYSFUNCTION WITH INDEX OF MICROCIRCULATORY RESISTANCE
Authors: Byung Ok Kim, Joung Hoon Kim, Young-Sup Byun, Hyo Seung Ahn, Choong Won Goh, Kun Joo Rhee, Euisuk Chung, Ji Min Chang, Bum-Kee Hong, Byoung Kwon Lee, Sanggye Paik Hospital
Journal: Journal of the American College of Cardiology (2012)
Carcinoembryonic Antigen and Monitoring of Metastatic Colorectal Carcinoma
Authors: JACOB J. LOKICH
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 October 1978Carcinoembryonic Antigen and Monitoring of Metastatic Colorectal CarcinomaJACOB J. LOKICH, M.D.JACOB J. LOKICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-573 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Shani and colleagues (1) on the use of serial measurements of plasma carcinoembryonic antigen (CEA) in patients with colorectal cancer has major clinical implications for the practicing oncologist, and the article should be carefully reviewed by all clinicians.The authors seem to be ambivalent with regard to the use of CEA, stating in the adverse column that CEA levels were not predictive of subsequent tumor response; were discordant in a "substantial" proportion of patients; were not correlated with patient survival; and were no more useful than the more simply and economically measured serum alkaline...References1. SHANIO'CONNELLMOERTALSCHUTTSILVERSGO AMCAAV: Serial plasma carcinoembryonic antigen measurements in the management of metastatic colorectal carcinoma. Ann Intern Med 88:627-630, 1978 LinkGoogle Scholar2. MAYER R: Carcinoembryonic antigen (CEA) as a monitor of chemotherapy in disseminated colorectal carcinoma. Cancer 1978, in press CrossrefGoogle Scholar3. LOKICH J: Sequential CEA levels as a predictor and monitor of response and relapse in the therapy of metastatic breast cancer. Submitted for publication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Sidney Farber Cancer Institute Charles A. Dana Cancer Center Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPrognostic factors in advanced colorectal carcinoma 1 October 1978Volume 89, Issue 4Page: 573-573KeywordsBlood plasmaCarcinoembryonic antigenColorectal cancer Issue Published: 1 October 1978 PDF DownloadLoading ...
Superficial Calcium Fracture After PCI as Assessed by OCT
Authors: Takashi Kubo, Kunihiro Shimamura, Yasushi Ino, Tomoyuki Yamaguchi, Yoshiki Matsuo, Yasutsugu Shiono, Akira Taruya, Tsuyoshi Nishiguchi, Aiko Shimokado, Ikuko Teraguchi, Makoto Orii, Takashi Yamano, Takashi Tanimoto, Hironori Kitabata, Kumiko Hirata, Atsushi Tanaka, Takashi Akasaka
Journal: JACC. Cardiovascular imaging (2015)
Abstract 2697: Role of a novel flavonoid enriched in ocimum sanctum linn for prostate cancer chemoprevention and therapy
Authors: Sharad S. Singhal, Lokesh Nagaprashantha, Jyotsana Singhal, Sanjay Awasthi
Journal: Cancer Research (2012)

Abstract The present study was conducted to determine the efficacy of novel flavonoid vicenin-2 (VCN-2), an active constituent of the medicinal herb Ocimum Sanctum Linn or Tulsi, as a single agent and in combination with docetaxel (DTL) in carcinoma of prostate (CaP). VCN-2 effectively induced anti-proliferative, anti-angiogenic and pro-apoptotic effect in CaP cells (PC-3, DU-145 and LNCaP) irrespective of their androgen responsiveness or p53 status. VCN-2 inhibited EGFR/Akt/mTOR/ p70S6K pathway along with decreasing c-Myc, cyclin D1, cyclin B1, CDK4, PCNA and hTERT in vitro. VCN-2 reached a level of 2.6 + 0.3 μM in serum after oral administration in mice which reflected that VCN-2 is orally absorbed. The i.v. administration of docetaxel (DTL), current drug of choice in androgen-independent CaP, is associated with dose-limiting toxicities like febrile neutropenia which has lead to characterization of alternate routes of administration and potential combinatorial regimens. In this regard, VCN-2 in combination with DTL synergistically inhibited the growth of prostate tumors in vivo with a greater decrease in the levels of AR, pIGF1R, pAkt, PCNA, cyclin D1, Ki67, CD31, and increase in E-cadherin. VCN-2 has been investigated for radio-protection and anti-inflammatory properties. This is the first study on the anti-cancer effects of VCN-2. In conclusion, our investigations collectively provide strong evidence that VCN-2 is effective against CaP progression along with indicating that VCN-2 and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. (Supported in part by NIH grant CA 77495) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2697. doi:1538-7445.AM2012-2697
Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor
Authors: Gregory L. Brown, Lillian B. Nanney, Joseph Griffen, Anne B. Cramer, John M. Yancey, Luke J. Curtsinger, Larry Holtzin, Gregory S. Schultz, Maurice J. Jurkiewicz, John B. Lynch
Journal: New England Journal of Medicine (1989)

Experimental studies in animals have demonstrated that the topical application of epidermal growth factor accelerates the rate of epidermal regeneration of partial-thickness wounds and second-degree burns. We conducted a prospective, randomized, double-blind clinical trial using skin-graft-donor sites to determine whether epidermal growth factor would accelerate the rate of epidermal regeneration in humans. Paired donor sites were created in 12 patients who required skin grafting for either burns or reconstructive surgery. One donor site from each patient was treated topically with silver sulfadiazine cream, and one was treated with silver sulfadiazine cream containing epidermal growth factor (10 μg per milliliter). The donor sites were photographed daily, and healing was measured with the use of planimetric analysis. The donor sites treated with silver sulfadiazine containing epidermal growth factor had an accelerated rate of epidermal regeneration in all 12 patients as compared with that in the paired donor sites treated with silver sulfadiazine alone. Treatment with epidermal growth factor significantly decreased the average length of time to 25 percent and 50 percent healing by approximately one day and that to 75 percent and 100 percent healing by approximately 1.5 days (P<0.02). Histologic evaluation of punch-biopsy specimens taken from the centers of donor sites three days after the onset of healing supported these results. We conclude that epidermal growth factor accelerates the rate of healing of partial-thickness skin wounds. Further studies are required to determine the clinical importance of this finding. (N Engl J Med 1989; 321:76–9.)
A Comparison of Particulate Matter from Biomass-Burning Rural and Non-Biomass-Burning Urban Households in Northeastern China
Authors: Ruoting Jiang, Michelle L. Bell
Journal: Environmental Health Perspectives (2008)

BackgroundBiomass fuel is the primary source of domestic fuel in much of rural China. Previous studies have not characterized particle exposure through time–activity diaries or personal monitoring in mainland China.ObjectivesIn this study we characterized indoor and personal particle exposure in six households in northeastern China (three urban, three rural) and explored differences by location, cooking status, activity, and fuel type. Rural homes used biomass. Urban homes used a combination of electricity and natural gas.MethodsStationary monitors measured hourly indoor particulate matter (PM) with an aerodynamic diameter ≤ 10 μm (PM10) for rural and urban kitchens, urban sitting rooms, and outdoors. Personal monitors for PM with an aerodynamic diameter ≤ 2.5 μm (PM2.5) were employed for 10 participants. Time–activity patterns in 30-min intervals were recorded by researchers for each participant.ResultsStationary monitoring results indicate that rural kitchen PM10 levels are three times higher than those in urban kitchens during cooking. PM10 was 6.1 times higher during cooking periods than during noncooking periods for rural kitchens. Personal PM2.5 levels for rural cooks were 2.8–3.6 times higher than for all other participant categories. The highest PM2.5 exposures occurred during cooking periods for urban and rural cooks. However, rural cooks had 5.4 times higher PM2.5 levels during cooking than did urban cooks. Rural cooks spent 2.5 times more hours per day cooking than did their urban counterparts.ConclusionsThese findings indicate that biomass burning for cooking contributes substantially to indoor particulate levels and that this exposure is particularly elevated for cooks. Second-by-second personal PM2.5 exposures revealed differences in exposures by population group and strong temporal heterogeneity that would be obscured by aggregate metrics.
Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFκB pathway in a human monocytic cell line, THP-1
Authors: Jidong Cheng, Hiroyasu Imanishi, Hiroko Morisaki, Weidong Liu, Hideji Nakamura, Takayuki Morisaki, Toshikazu Hada
Journal: Journal of Hepatology (2005)
Prospective study of asthma in relation to smoking habits among 14,729 adults.
Authors: E Vesterinen, J Kaprio, M Koskenvuo
Journal: Thorax (1988)

The prevalence and incidence of asthma in relation to cigarette smoking habits was studied in a population of 14,729 Finnish adult men and women who participated in a postal health survey in 1975. Of those invited to participate in a new survey in 1981, 89.7% replied. Asthma was diagnosed on the basis of self reporting of asthma diagnosed by a physician and by record linkage to a national register of hospital admissions to all general and tuberculosis hospitals during 1972 and 1983. The prevalence of diagnosed asthma in 1975 was significantly higher among male smokers than among male non-smokers (relative risk (RR) = 1.73); no significant difference was observed for women (RR = 1.33). People with asthma were slightly but not significantly more likely to stop smoking during the six year follow up period (RR = 1.23). The incidence of asthma among those who had neither reported asthma in 1975 nor been admitted to hospital for asthma before the 1975 questionnaire study was not significantly higher among smokers than among non-smokers during follow up. Although possible mechanisms exist to explain how smoking could have a role in the aetiology of asthma, this study suggests that smoking is not a strong risk factor for asthma.
Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts
Authors: J SUZUKI, M OGAWA, Y SAGESAKA, M ISOBE
Journal: Cardiovascular Research (2005)

Tea catechins have many biological functions; these effects are induced by the suppression of several inflammatory factors. However, effects of catechins on cardiac allograft rejection have not been well investigated.To test the hypothesis that catechins can attenuate ventricular remodeling and graft arterial diseases (GAD) in cardiac rejection, we orally administered catechins to murine cardiac recipients. We analyzed the mechanisms using immunohistochemistry, RNase protection, gel mobility shift, and cell proliferation assays. Although severe myocardial cell infiltration, fibrosis, and GAD with enhancement of inflammatory factors were observed in untreated class II mismatch allografts at day 60, catechins attenuated these changes with altered Th1/Th2 cytokine balance and suppressed NF-kappaB activation and cell proliferation.Catechins are potent agents for the suppression of chronic rejection because they are critically involved in the suppression of proinflammatory signaling pathways.
Abstract 2396: Device-Based Heart Failure Management: Multi-Frequency Impedance Measurements to Optimize Intrathoracic Fluid Monitoring
Authors: Sebastian K Maier, Jan Becher, Susann E Kaufmann, Wolfgang R Bauer, Stefan Paule, Michael Lippert, Olaf Skerl, Bernhard Fahn, Georg Ertl
Journal: Circulation (2008)

Introduction: Recently, it was shown that continuous implant-based measurements of intrathoracic impedance (Z) as a surrogate measure of intrathoracic fluid status allows detection of cardiac decom...
Circulating 3,3', 5'-triiodothyronine (reverse T3) in the human newborn.
Authors: I J Chopra, J Sack, D A Fisher
Journal: Journal of Clinical Investigation (1975)

Serum concentrations of 3,3',5'-triiodothyronine (reverse T3 rT3), 3,3',5-triiodothyronine (T), and thyroxine (T4) were measured in cord blood and invenous blood samples obtained between 2 h and 30 days of postnatal life from healthy full-term newborn infants. The mean serum rT3 concentration of (mean plus or minus SE) 151 plus or minus 12 ng per 100 ml in 18 cord blood samples was significantly higher than the level (41 plus or minus 2 ng per 100 ml) in 27 normal adult sera; the corresponding mean serum T4 of 12.7 plus or minus 0.8 mug per 100 ml in cord blood also was significantly higher than that (8.6 plus or minus 1.9 mug per 100 ml) in 108 normal adults. By contrast, the mean serum T3 concentration in 15 cord blood samples, 24 plus or minus 3 mg per 100 ml, was significantly lower than the value of 126 plus or minus 3.2 ng per 100 ml measured in 108 normal adults. At 4 h of age the mean serum rT3 concentration (165 plus or minus 13 ng per 100 ml) in six newborns was 4ot significantly different from that in paired cord blood samples (194 plus or minus 25 ng per 100 ml); on the other hand, whenever, studied, the mean serum T3 and T4 levels were significantly higher at 4 h than at birth. The failure of serum rT3 concentrations to rise after delivery in response to the early neonatal thyrotropin (TSH) surge and at a time when serum T3 and T4 levels increase significantly prompted a study of the rT3 response to 10 IU of intramuscular TSH in three healthy adult subjects. Just as in the newborns, serum rT3 failed to rise appreciably in these subjects, even though serum T3 and T4 showed the expected increments. Serum rT3 concentrations in 1-4 day-old newborn infants did not differ significantly from values in the cord blood but were significantly lower in older neonates. The mean serum rT3 level in 5-7-day-old infants was higher than that in normal adults, but in 9-11 day and 20-30-day-old infants, mean rT3 values were statistically similar to the adult value. The mean serum T3 concentrations in neonates between 1-30 days old were either higher than or comparable to the values of normal adults. The mean serum T4 concentrations in neonates between birth and 30 days of age were significantly higher than the mean adult level. The mean serum rT3 to T4 ratios (rT3/T4) were elevated in 1-4-day-old neonates; the values in older neonates were similar to those in adults. These results suggest that (a) factors other than TSH are important modulators of serum rT3 in man; (b) high serum rT3 concentration in the newborn becomes comparable to that in the normal adult by 9-11 days of neonatal life.
Factors Determining the Attack Rate of Rheumatic Fever
Authors: Gene H. Stollerman
Journal: JAMA (1961)

Recent studies, summarized in this report, showed that the attack rate of primary and secondary rheumatic fever was conditioned by the virulence and epidemicity of infecting strains of Group A streptococci and was related to the magnitude of the streptococcal immune response. Rheumatic fever occurred only twice (0.3%) following untreated mild streptococcal pharyngitis in 608 children in a Chicago pediatric clinic. Only 14% of the infections observed were comparable clinically, bacteriologically and immunologically to streptococcal pharyngitis observed in military epidemics. The frequency of recurrences of rheumatic fever was also related to the magnitude of the streptococcal immune response but was considerably greater in patients with rheumatic heart disease than in rheumatic subjects with normal hearts.
Low dosages of interleukin 1 protect mice against lethal cerebral malaria.
Authors: J H Curfs, J W van der Meer, R W Sauerwein, W M Eling
Journal: The Journal of Experimental Medicine (1990)

In cerebral malaria, pathological changes can be found in the brain of infected people and in the brain of Plasmodium berghei-infected mice. The pathogenesis of cerebral malaria in mice is believed to be due to an immunopathological reaction giving rise to an excessive production of cytokines such as interferon gamma (IFN-gamma) and tumor necrosis factor (TNF). We find that low doses of interleukin 1 (IL-1) protect mice against cerebral malaria; IL-1 also inhibits parasitemia. The IL-1 effect on parasitemia was not observed in nude mice and was at least partly reversed in mice treated with IL-1 in combination with antibody to IFN-gamma, indicating the involvement of T cells. Mice protected against development of cerebral malaria by IL-1 treatment developed the syndrome when TNF was given as observed in control infected mice or infected mice treated with inactivated IL-1.
Increased interleukin 5 production in eosinophilic S?zary syndrome: Regulation by interferon alfa and interleukin 12
Authors: Karen Rebecca Suchin, Maureen Cassin, Scott L. Gottleib, Shobana Sood, Andrew J. Cucchiara, Eric C. Vonderheid, Alain H. Rook
Journal: Journal of the American Academy of Dermatology (2001)
Control of Breast Cancer Through Mass Screening-Reply
Authors: Philip Strax
Journal: JAMA (1976)

I am deeply grateful to Dr Cortell for calling attention to the obvious error noted. Of course, the HIP  was conducted among 62,000 randomly selected women, aged 40 to 64 years, all without apparent breast cancer or history of such, one half of whom were called the study group who were invited to have the screening examination and an equal number of matched women in a control group. Gremlins are present even inThe Journal.  Control is used in the article in the literal sense of  of  It does not necessarily follow, as suggested by the author, that the increased percentage of no axillary involvement equates with lowered mortality. Although in all the women, a lower nodal involvement was present in the  group, mortality reduction was present only in women more than 50 years of age.  The writer correctly stresses the need of both