Liver Function Tests and Needle Biopsy in the Diagnosis of Metastatic Cancer of the Liver
Authors: RAYMOND YESNER
Journal: Annals of Internal Medicine (1963)

Article1 July 1963Liver Function Tests and Needle Biopsy in the Diagnosis of Metastatic Cancer of the LiverRAYMOND YESNER, M.D., HAROLD O. CONN, M.D.RAYMOND YESNER, M.D.Search for more papers by this author, HAROLD O. CONN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-62 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the many papers written about liver function tests in the diagnosis of metastatic liver disease (1-17), the value of such tests remains uncertain. Some investigations measured only a single test of liver function (1, 2, 5, 7, 14, 17), some studied small groups of patients (1, 3, 4, 6, 7, 12), and in other patients the presence of hepatic metastases was based solely on clinical evidence (1, 14).To assess properly the diagnostic role of liver function tests in metastatic cancer of the liver, the tests should be performed and interpreted without regard to signs or symptoms suggestive of...References1. MERANZEMERANZEROTHMAN DRTMM: Serum phosphatase as an aid in the diagnosis of metastasis of cancer to the liver. Penn. Med. J. 41: 1160, 1938. Google Scholar2. GUTMANOLSONGUTMANFLOOD ABKBEBCA: Effect of disease of the liver and biliary tract upon the phosphatase activity of the serum. J. Clin. Invest. 19: 129, 1940. CrossrefMedlineGoogle Scholar3. ABELSREKERSBINKLEYPACKRHOADS JCPEGEGTCP: Metabolic studies in patients with cancer of the gastrointestinal tract. Ann. Intern. Med. 16: 221, 1942. LinkGoogle Scholar4. 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HICKSHOLTGUERRANTLEAVELL MHHPJLBS: The effect of spontaneous and artificial fever on liver function. J. Clin. Invest. 27: 580, 1948. CrossrefGoogle Scholar34. CHAVEZSEPULVEDAORTEGA IBA: The functional value of the liver in heart disease. JAMA 121: 1276, 1943. CrossrefGoogle Scholar35. SIMEONE FA: Traumatic shock. The physiologic effects of blood loss. Bull. New Eng. Med. Center 10: 112, 1948. MedlineGoogle Scholar36. RAFSKYNEWMAN HAB: Liver function tests in the aged. Amer. J. Dig. Dis. 10: 66, 1943. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAYMOND YESNER, M.D.; HAROLD O. CONN, M.D.Affiliations: West Haven, ConnecticutFrom the Laboratory and Medical Services of the West Haven Veterans Administration Hospital, and the Departments of Pathology and Internal Medicine, Yale University School of Medicine.This work was supported in part by grant C-2727, United States Public Health Service, Washington, D. C., and was partly performed during the tenure of a Veterans Administration Clinical Investigatorship by Dr. Conn.Requests for reprints should be addressed to Harold O. Conn, M.D., Veterans Administration Hospital, West Haven 16, Connecticut. 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CONN, M.D., RAYMOND YESNER, M.D. 1 July 1963Volume 59, Issue 1_Part_1Page: 62-73KeywordsBiopsyHospital medicineLiverLiver diseasesLiver function testsMedical servicesPathology and laboratory medicinePhosphatasesResearch laboratoriesSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 July 1963 PDF downloadLoading ...