Mediastinal Germ Cell Cancers in Klinefelter's Syndrome
Authors: A. Robert Turner, R. Neil Macdonald, J. Alan L. Gilbert, Sigurdur Petursson
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 February 1981Mediastinal Germ Cell Cancers in Klinefelter's SyndromeA. ROBERT TURNER, M.D.C.M., R. NEIL MACDONALD, M.D.C.M., J. ALAN L. GILBERT, M.D., SIGURDUR PETURSSON, M.D.A. ROBERT TURNER, M.D.C.M.Search for more papers by this author, R. NEIL MACDONALD, M.D.C.M.Search for more papers by this author, J. ALAN L. GILBERT, M.D.Search for more papers by this author, SIGURDUR PETURSSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-2-279_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Klinefelter's syndrome (XXY) patients have gynecomastia, small testes, azoospermia, and elevated levels of circulating gonadotropins (1). They also have an extra X chromosome that is a result of nondisjunction during meiosis (1). This common genetic disorder occurs in between 1:400 and 1:1000 of male births (1). We report here three patients with Klinefelter's syndrome who presented with a nonseminomatous tumor of the mediastinum. These observations lend support to the suggestion the dysgenetic germ cell tissue in Klinefelter's syndrome patients has an increased malignant potential (2).A 23-year-old patient (Case 1) had had gynecomastia for 5 years. The...References1. : Klinefelter syndrome and breast cancer. Hopkins Med J. 1976;138:102-8. MedlineGoogle Scholar2. SOGGEMCDONALDCOFOLD MSP. The malignant potential of the dysgenetic germ cell in Klinefelter's syndrome. Am J Med. 1979;66:515-8. CrossrefMedlineGoogle Scholar3. FEUNSAMSONSTEPHENS LMR. Vinblastine (VLB), bleomycin (BLEO), cis-diamminedichloroplatinum (DDP) in disseminated extragonadal germ cell tumors. Cancer. 1980;45:2543-9. CrossrefMedlineGoogle Scholar4. WALDENWOODSFOXBAGSHAWE PRBK. Primary mediastinal trophoblastic teratomas. Thorax. 1977;32:752-8. CrossrefMedlineGoogle Scholar5. BEATTIE E Mediastinal germ cell tumors (surgery). Semin Oncol. 1979;6:109-12. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimary Germ Cell Tumors of the ThoraxKlinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology GroupPrimary Germ Cell Tumors of the ThoraxProtocol for the Examination of Specimens From Pediatric and Adult Patients With Extragonadal Germ Cell TumorsExtragonadal Germ Cell Tumors: A Review With Emphasis on Pathologic Features, Clinical Prognostic Variables, and Differential Diagnostic ConsiderationsKlinefelter syndrome and mediastinal germ cell tumorsDiagnosis, staging, and clinical characteristics of the patient with mediastinal germ cell carcinomaGerm Cell Neoplasms and Other Malignancies of the MediastinumChromosome abnormalities of eighty-one pediatric germ cell tumors: Sex-, age-, site-, and histopathology-related differences?a Children's Cancer Group studyCerebral germ cell tumor and XXY karyotypeMediastinal germ cell tumour associated with Klinefelter syndromeIsochromosome 12p in mediastinal germ cell tumorGenetic Abnormalities in Men with Germ Cell TumorsCerebral germinomas and klinefelter syndrome.A reviewTesticular germ cell tumor in patient with klinefelter syndromeTesticular failure in patients with extragonadal germ cell tumorsBenign mediastinal teratoma associated with Klinefelter's syndromeImmune Competence in Patients with Klinefelter’s SyndromeChoriocarcinoma, thyrotoxicosis, and the klinefelter syndromeChromosomal abnormalities of a mediastinal embryonal cell carcinoma in a patient with 47,XXY Klinefelter syndrome: Evidence for the premeiotic origin of a germ cell tumorGynecomastia After Cytotoxic Therapy for Metastatic Testicular CancerKlinefelter's Syndrome and Mediastinal Teratoma 1 February 1981Volume 94, Issue 2Page: 279-279KeywordsBirthGenetic diseasesGerm cell cancerGerm cellsGonadotropinsTestesX chromosomes ePublished: 1 December 2008 Issue Published: 1 February 1981 PDF downloadLoading ...