tbuckley/cabot-search huggingface dataset:
Late dysrhythmias and disturbances of conduction following Mustard operation for complete transposition of the great arteries.
Authors: P M Clarkson, B G Barratt-Boyles, J M Neutze
Journal: Circulation (1976)

Between 1964 and 1971, 49 patients were discharged from hospital following atrial baffle repair for transposition of the great arteries. Electrocardiograms of 47 of these patients were available for review seven months to eight and a half years (average 31 months) after operation. Of the 46 patients in sinus rhythm prior to operation, 40 (87%) were in sinus rhythm with normal atrioventricular conduction when last seen. Four patients (8.7%) had benign supraventricular dysrhythmias: three were junctional, one was atrial. None was noted to experience rapid dysrhythmias. Two patients showed evidence of abnormal atrioventricular conduction. There were five late deaths but in only one of these patients was a dysrhythmia a possible factor. The effects of variations in caval cannulation, extent of excision of the atrial septum and placement of the baffle suture line on the rhythm present at last review were examined. To preserve sinus rhythm it appears necessary to avoid surgical trauma in the vicinity of both the sinus node and the A-V node. Preservation of the internodal tracts appears less important. It is uncertain whether the 'sinus' rhythm seen after operation originates in the sinoatrial node but the rhythm is functionally similar.
Platelet/polymorphonuclear leukocyte adhesion: a new role for SRC kinases in Mac-1 adhesive function triggered by P-selectin
Authors: Paola Piccardoni, Rita Sideri, Stefano Manarini, Antonio Piccoli, Nicola Martelli, Giovanni de Gaetano, Chiara Cerletti, Virgilio Evangelista
Journal: Blood (2001)
Early Cancer Clinical Trials: Safety, Numbers, and Consent
Authors: Michael J. Hawkins
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Early Cancer Clinical Trials: Safety, Numbers, and Consent Get access Michael J. Hawkins Michael J. Hawkins Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 20, 20 October 1993, Pages 1618–1619, https://doi.org/10.1093/jnci/85.20.1618 Published: 20 October 1993 Article history Received: 13 September 1993 Accepted: 14 September 1993 Published: 20 October 1993
Medicine and Nuclear War
Authors: Lachlan Forrow, Victor W. Sidel
Journal: JAMA (1998)

To determine how physicians might participate in the prevention of nuclear war in the post–Cold War era, we review, from a medical perspective, the history of the nuclear weapons era since Hiroshima and the status of today's nuclear arsenals and dangers. In the 1950s, physicians were active partners in governmental civil defense planning. Since 1962, physicians have stressed prevention of nuclear war as the only effective medical intervention. Public advocacy by physicians helped end both atmospheric nuclear testing in the 1960s and superpower plans for fighting a nuclear war in the 1980s. Today's dangers include nuclear arms proliferation, an increasing risk of nuclear terrorism, and the 35,000 warheads that remain in superpower nuclear arsenals, many still on hair-trigger alert. Physicians have recently joined with military and political leaders and over 1000 citizens' organizations in calling for the complete elimination of nuclear weapons. Global medical collaboration in support of a verifiable and enforceable Nuclear Weapons Convention would be a major contribution to safeguarding health in the 21st century.
RENAL FAILURE IN LAENNEC'S CIRRHOSIS. II. SIMULTANEOUS DETERMINATION OF CARDIAC OUTPUT AND RENAL HEMODYNAMICS*
Authors: Ruben G. Lancestremere, Paul L. Davidson, Laurence E. Earley, Frederick J. O'brien, Solomon Papper
Journal: Journal of Clinical Investigation (1962)

A number of observations in patients with Laennec's cirrhosis dying with renal failure-one of the conditions sometimes included in the term hepatorenal syndrome-suggest that the observed oliguria and nitrogen retention may be secondary to impaired renal perfusion rather than to any lesion of the renal parenchyma. First, renal failure may develop with great rapidity. In several instances, normal glomerular filtration rate (GFR) had been demonstrated months, weeks, and even days before the development of renal failure (1). Second, renal failure may occur in patients with cirrhosis after mild gastrointestinal bleeding, not severe enough to produce significant change in hematocrit, or after abdominal paracentesis, even when only five liters of fluid are removed (1-3). Minimal bleeding and paracente
Merck offers money back guarantee on finasteride
Authors: A Tonks
Journal: BMJ (1994)

Merck, the American drug manufacturer, is offering a money back guarantee with finasteride (Proscar), its new drug treatment for benign prostatic hyperplasia. The company is offering to refund the cost of the drug if it fails to improve symptoms within six months or if the patient needs prostatic surgery within two years.

Finasteride is an antiandrogen, prescribed by general practitioners and urologists, which inhibits the metabolism of testosterone, reducing the volume of prostatic tissue and improving urinary flow rates in men with benign prostatic hyperplasia. It is the only drug of its class and, according to …
Serum Carotenoids, α -Tocopherol, and Lung Function among Dutch Elderly
Authors: LINDA GRIEVINK, FROUWKJE G. de WAART, EVERT G. SCHOUTEN, FRANS J. KOK
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Antioxidant vitamins (provitamins) may protect against loss of lung function over time. We studied the association between serum carotenoids ( α -carotene, β -carotene, lycopene, β -cryptoxanthin, zeaxanthin, and lutein), α -tocopherol, and lung function among noninstitutionalized Dutch elderly age 65 to 85 yr (n = 528). Multiple linear regression analysis was performed with FEV1 or FVC as dependent variables and serum levels of antioxidants in quintiles as independent variables. We adjusted for age, gender, height, and pack-years of smoking. Subjects in the fifth quintile of serum β -carotene had a 195 ml (95% confidence interval [95% CI]: 40 to 351 ml) higher and those in the fifth quintile of α -carotene had a 257 ml (95% CI: 99 to 414 ml) higher FEV1 compared with subjects in the first quintile of these carotenoids. Significant (p < 0.05) positive trends were observed between α -carotene, β -carotene, lycopene, and FEV1 and between α -carotene, β -carotene, and FVC. Subjects in the highest quintile of the other carotenoids or α -tocopherol did not have significantly higher FEV1 or FVC compared with subjects in the first quintile of these antioxidants. In conclusion, this study shows that from the six major serum carotenoids and α -tocopherol studied, particularly α -carotene, β -carotene, and lycopene were positively associated with lung function in the elderly and may be considered as candidates for further investigations. Grievink L, de Waart FG, Schouten EG, Kok FJ. Serum carotenoids, α -tocopherol, and lung function among Dutch elderly.
Whole-Body Vibration Therapy for Osteoporosis: State of the Science
Authors: Andrea Wysocki, Mary Butler, Tatyana Shamliyan, Robert L. Kane
Journal: Annals of Internal Medicine (2011)

Clinical guidelines for osteoporosis recommend dietary and pharmacologic interventions and weight-bearing exercise to prevent bone fractures. These interventions sometimes have low adherence and can cause adverse effects. A proposed alternative or adjunctive treatment is whole-body vibration therapy (WBV), in which energy produced by a forced oscillation is transferred to an individual from a mechanical vibration platform. Whole-body vibration platforms are not approved by the U.S. Food and Drug Administration for medical purposes. This review provides a broad overview of important issues related to WBV therapy for prevention and treatment of osteoporosis. Relying on key informants and a search of the gray and published literature from January 2000 to August 2011, the investigators found that the designs of WBV platforms and protocols for their use vary widely. The optimal target population for the therapy is not defined. Although WBV has some theoretical advantages, key informants have voiced several concerns, including uncertain safety and potential consumer confusion between low-intensity vibration platforms intended for osteoporosis therapy and high-intensity platforms intended for exercise. Finally, the scant literature did not establish whether WBV therapy leads to clinically important increases in bone mineral density or reduces risk for fracture.
Mountain-Climbing Safety
Authors: B. G. Ferris
Journal: New England Journal of Medicine (1963)

A PREVIOUS report1 discussed mountaineering accidents and their causation. The present report outlines preventive measures that mountain climbers can take to ensure their enjoying this sport safely.As in any sport that demands a high level of physical exertion, physical condition is of prime importance. Improving physical condition involves increasing muscular strength and endurance, as well as improving skill in the various technics used. One may do this by gradually increasing the amount of physical exertion, as by increasing the speed at which a given climb is done or by increasing the load carried. This last point should be emphasized . . .
Payment for Laboratory Survey in Hereditary Disease
Authors: Halford S. Whitaker
Journal: JAMA (1963)

To the Editor:—  With the current interest in the hereditary nature of disease and the aid to be derived from a positive family history in many diseases, the physician finds himself studying persons who would not have been seen formerly.  Furthermore, we may find that we need laboratory tests on the patient's relatives. This poses a problem of whom to charge. When relatives of an outpatient are tested, one may bill the patient directly if he agrees. For a hospitalized patient the same procedure should apply. If the diagnosis and hospital care of the patient are being paid for by his health insurance, may one not assume that his insurance will pay for these tests also? As these tests are an essential part of the diagnosis or its confirmation, they become an essential part of the care and diagnostic tests for which the insurance provides.  Let us then accept and
Systemic Heparinization for Femoral Percutaneous Coronary Arteriography
Authors: Weldon J. Walker, Stanley L. Mundall, Harris G. Broderick, Baidyanath Prasad, June Kim, Judson M. Ravi
Journal: New England Journal of Medicine (1973)

THROMBOEMBOLIC complications during percutaneous coronary arteriography have frequently been described.1 2 3 4 5 6 7 8 9 Three university hospitals reported higher morbidity and mortality during coronary arteriography performed by the Judkins percutaneous femoral than with the Sones right brachial arteriotomy technic.3 The two methods employ different types of catheters, with guide wires used only in the Judkins procedure. At the beginning of the Sones procedure approximately 5000 U of "local" heparin are usually injected into the artery to prevent local thrombosis. Heparin injection is not routine during the Judkins procedure. During both methods the catheter is flushed frequently with dilute heparin solution. It is now evident . . .
Clinical pearls from atopic dermatitis and its infectious complications
Authors: K.H. Kim
Journal: British Journal of Dermatology (2014)

Journal Article Clinical pearls from atopic dermatitis and its infectious complications Get access K.H. Kim K.H. Kim Department of Dermatology Seoul National University Hospital 101 Daehak‐ro Jongno‐gu Seoul 110‐744 Korea Correspondence Kyu‐Han Kim. E‐mail: kyuhkim@snu.ac.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue s1, 1 July 2014, Pages 25–30, https://doi.org/10.1111/bjd.12919 Published: 01 July 2014
Altered degradation of extracellular matrix in myocardial remodelling: the growing role of cathepsins and cystatins
Authors: J. Diez
Journal: Cardiovascular Research (2010)

This editorial refers to ‘Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation’ by L. Xie et al. , doi:10.1093/cvr/cvq138 

Alterations in the heart's extracellular matrix, composed predominantly of fibrillar collagens types I and III, can contribute importantly to a structural remodelling of the myocardium that leads to ventricular dysfunction during either diastolic or systolic phases of the cardiac cycle. Collagen is a stable protein whose balanced turnover (synthesis and degradation) by cardiac fibroblasts can be lost under pathological conditions ( Figure 1 ).1 When collagen synthesis predominates over its degradation, the resulting interstitial and perivascular accumulation of collagen will lead to fibrosis. On the contrary, when degradation of collagen predominates over its synthesis, the resulting loss of collagen will lead to the disruption of the physiological collagen scaffold.

Among the many proteolytic enzymes present in the myocardium and involved in collagen degradation, members of the matrix metalloproteinase (MMP) family have received most attention. However, cathepsins and their inhibitors (i.e. cystatins) have been also implicated in collagen degradation. Cathepsins B, S, L, and K are cysteine proteases, which, when released from the lysosomes to the pericellular space, degrade extracellular matrix proteins such as elastin and fibrillar collagens.2 In addition, secreted cathepsins may activate pro-MMPs to active matrix-degrading enzymes.3 On the other hand, cystatins C, D, S, and SA are secretory proteins that act as the endogenous inhibitors of cathepsins.4 … 

*Corresponding author. Tel: +34 948 194700; fax: +34 948 194716, Email: jadimar{at}unav.es
RUPTURE OF SPLEEN IN MALARIAL THERAPY IN SYPHILIS
Authors: S. H. POLAYES
Journal: JAMA (1931)

Rupture of the spleen in naturally acquired malaria is considered by Osler 1 to be a very rare complication. Manson-Bahr 2 finds that in naturally acquired malaria the mortality from ruptured spleen is only about one in every hundred thousand infections. Davidson 3 found 3 cases of ruptured spleen in 30,000 cases of malaria.  A review of the literature on malarial therapy for syphilis of the central nervous system, however, reveals a greater number of cases of ruptured spleen than would be expected, judging both from the statements referred to and from the observations of such authorities as Wagner-Jauregg (the father of induced malarial therapy), Weygandt, Driver and others. In a communication to Tromner 4 dated July 9, 1925, Wagner-Jauregg stated that, in more than 1,200 cases treated by induced malaria since 1919, neither he nor his assistants found a single case of splenic rupture. Driver, 5 in a review
Recent advances in non-invasive cardiology
Authors: John Chambers, Kevin Fox, Alan Fraser
Journal: BMJ (2005)

Family history of breast cancer Referral guidelines changed after acceptance of 10 minute consultationEditor-In their 10 minute consultation on family history of breast cancer Lucassen and Watson drew attention to the recently published guidelines from the National Institute for Clinical Excellence (NICE) on familial breast cancer. 1 2 It is unfortunate that the referral criteria were changed between the acceptance of this article in December 2003 and the final published guidelines in June 2004, which would result in the referral of the patient highlighted in the article for potential mammography screening, rather than for her reassurance.Women aged 40-49 years at moderate risk of breast cancer are entitled to annual mammograms. 2 The definition of moderate risk was based on a risk of at least 3% over the 10 year period from the age of 40 to 50.Available evidence, particularly from combined analyses of case-control studies of familial risks, 3 indicates that a woman reaches this category with a first degree relative (mother or sister) with breast cancer when younger than 40 years or two relatives on the same side of the family (one first degree and one second degree or two first degree) diagnosed at any age.The latter category differs from the draft NICE guidelines and previous referral criteria, which required that the two relatives be diagnosed at an average age of less than 60. 4 This age restriction was removed because it could not be justified on the basis of the available data.It should be noted, however, that referral on the basis of two elderly close relatives is likely to be restricted to the age groups of 30-49, with referral of only high risk groups (for example, two affected relatives diagnosed at an average age of less than 50 years) outside this age group.
Remarks ON THE CLINICAL AND BACTERIOLOGICAL ASPECTS OF AN EPIDEMIC SIMULATING INFLUENZA, WHICH HAS RECENTLY OCCURRED IN THE EAST HERTS DISTRICT
Authors: R. A. Dunn, M. H. Gordon
Journal: BMJ (1905)

AN EPIDEMIO SIMULATING INFLUENZA.the patients, in many cases the spread of the disease, and the towns and villages in which it occurred.SUMMARY OF RESULTS.I must therefore be content to give the following summary of results:Of I62 patients of whom notes were made, a non-Gram-staining diplo- coccus was found in 63, 24 of which were obtained in pure culture, and te.ted by Dr. Gordon.Of these 162 patients 84 were males and 78 were females.98 had a temperature below 1020, and 21 a tem- perature above this.,, ,, 98 had sore-throat.96 had nasal discharge.39 had conjunctivitis.,, ,, 60 had cough.,, ,, 49 had a scarlatinal (irritable In 32), 2 a purpurlc, 3 a papular, 3 a morbilliform, and 3 an urticarial rash.49 had desquamation.29 had herpes.85 had vomiting.8K had stiff-neck., , had enlarged glands.., ,, 103 lhad cephalic pain.46 had cervical pain., , had spinal pain.,, ,, 0o had thoracic pain.,, ,, J14 had abdominal pain ,, ,, 42 had general pain., , had oedema.20 had albuminuria., had haematuria.23 had rigors.37 had delirium.,,,, 62 bad drowsiness., ,, 68 bad constipation. 6had diarrhoea.3 K had retraction of the head.1 3 had hyperaesthesla., bad dilatation of the pupils.,5 had convulsions.i , had photophobia.s ,, i9 had vertigo.
Quadruple-drug therapy was better than triple-drug therapy for eradicating<i>Helicobacter pylori</i>in adults
Authors: Nicholas J. Talley
Journal: Annals of Internal Medicine (2011)

Source Citation Malfertheiner P, Bazzoli F, Delchier JC, et al. Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. Lancet. 2011;377:905-13. 21345487
Exorcising the devil: Adding details to a descriptive account of oculomotor control
Authors: Gregory J. Zelinsky
Journal: Behavioral and Brain Sciences (1999)

Findlay &amp; Walker give voice to several common lines of thought regarding oculomotor control but do not provide sufficient detail for a critical evaluation of their theory. I argue that arbitrary spatial and temporal saccade metrics can be produced simply by manipulating the initial activation values in their model – values that the authors never specify. This lack of detail makes it difficult to anticipate the model's specific oculomotor behavior, or to compare this behavior to models opting for a more quantitative framework.
Diagnostic accuracy of noninvasive coronary imaging using 16-detector slice spiral computed tomography with 188 ms temporal resolution
Authors: Axel Kuettner, Torsten Beck, Tanja Drosch, Klaus Kettering, Martin Heuschmid, Christof Burgstahler, Claus D. Claussen, Andreas F. Kopp, Stephen Schroeder
Journal: Journal of the American College of Cardiology (2004)
The role of oncogenic MUC1-C in brachyury-induced immunotherapy resistance
Authors: Justin David, Duane Hamilton, Jeffrey Schlom, Claudia Palena
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Epithelial-mesenchymal transition (EMT) is a molecular and cellular program in which epithelial cells lose their well-differentiated phenotype and adopt mesenchymal characteristics. This process occurs during the progression of cancer to metastatic disease, and is also associated
Noise in Medical Helicopters-Reply
Authors: Richard C. Hunt
Journal: JAMA (1991)

In Reply.  —We appreciate Garner's clinical experience verifying that it is not possible to auscultate breath sounds during air medical transport. We concur that noise also compromises the ability to auscultate blood pressures. State-of-the-art, noninvasive, automated blood pressure monitors are in widespread use in air medical services, but they frequently cannot be relied on at low pressures. Technological advances are desperately needed in the monitoring of blood pressure and breath sounds during flight.  Garner doubts whether air medical services are flying critical care  In the civilian setting, air medical service helicopters are commonly staffed by medical personnel who have the highest level of training and the most experience in emergency and critical care. Medical equipment is typically that used in emergency departments and/or critical care units.  The medical community has had an unrealistic expectation that medical crews and their equipment can perform the same tasks during helicopter flight as
Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392
Authors: Floriana De Bellis, Vincenzo Carafa, Mariarosaria Conte, Dante Rotili, Francesca Petraglia, Filomena Matarese, Kees-Jan Françoijs, Julien Ablain, Sergio Valente, Rèmy Castellano, Armelle Goubard, Yves Collette, Amit Mandoli, Joost H.A. Martens, Hugues de Thé, Angela Nebbioso, Antonello Mai, Hendrik G. Stunnenberg, Lucia Altucci
Journal: Cancer Research (2014)

HDAC inhibitors (HDACi) are widely used in the clinic to sensitize tumorigenic cells for treatment with other anticancer compounds. The major drawback of HDACi is the broad inhibition of the plethora of HDAC-containing complexes. In acute promyelocytic leukemia (APL), repression by the PML-RARα oncofusion protein is mediated by an HDAC-containing complex that can be dissociated by pharmacologic doses of all trans retinoic acid (ATRA) inducing differentiation and cell death at the expense of side effects and recurrence. We hypothesized that the context-specific close physical proximity of a retinoid and HDACi-binding protein in the repressive PML-RARα-HDAC complex may permit selective targeting by a hybrid molecule of ATRA with a 2-aminoanilide tail of the HDAC inhibitor MS-275, yielding MC2392. We show that MC2392 elicits weak ATRA and essentially no HDACi activity in vitro or in vivo. Genome-wide epigenetic analyses revealed that in NB4 cells expressing PML-RARα, MC2392 induces changes in H3 acetylation at a small subset of PML-RARα-binding sites. RNA-seq reveals that MC2392 alters expression of a number of stress-responsive and apoptotic genes. Concordantly, MC2392 induced rapid and massive, caspase-8-dependent cell death accompanied by RIP1 induction and ROS production. Solid and leukemic tumors are not affected by MC2392, but expression of PML-RARα conveys efficient MC2392-induced cell death. Our data suggest a model in which MC2392 binds to the RARα moiety and selectively inhibits the HDACs resident in the repressive complex responsible for the transcriptional impairment in APLs. Our findings provide proof-of-principle of the concept of a context-dependent targeted therapy.
Comparison of narrow-band (311 nm) UVB and broad-band UVA after oral or bath-water 8-methoxypsoralen in the treatment of psoriasis
Authors: Bernhard Ortel, S. Perl, T. Kinaciyan, P.G. Calzavara-Pinton, H. Hönigsmann
Journal: Journal of the American Academy of Dermatology (1993)