tbuckley/cabot-search huggingface dataset:
The Drug Treatment of Depression
Authors: H. L. P. Resnik
Journal: JAMA (1970)

<h3>To the Editor.—</h3> There is no question but that Dr. Motto has clearly echoed my warning to the physician, "Do not be a psychopathogenic carrier of the suicidococcus contagiosa!" He indicates correctly that anxiety may exist within the physician which prevents him from diagnosing and managing suicidal conditions. However, I feel that Dr. Motto may have also contributed to<i>raising</i>that same anxiety for he would take from the practicing physician a useful tool—the antidepressant drugs. He states: "I fail to find even reasonable (not to say convincing) evidence of antidepressive effects in my own depressed patients... [nor] more than a mild tranquilizing effect." I would like to point out that when the results of 36 double-blind studies comparing imipramine hydrochloride, one of the more potent antidepressants, and a placebo are combined, 70% of the patients receiving imipramine are rated improved, while only 39% of the patients receiving a
866 IDENTIFICATION OF NOVEL CELLULAR TARGETS IN HUMAN INTRAHEPATIC CHOLANGIOCARCINOMA USING LASER MICRODISSECTION AND AMT-TAG PROTEOMICS
Authors: A. Dos Santos, M. Court, V. Thiers, S. Sar, C. Guettier, D. Samuel, C. Brechot, J. Garin, F. Demaugre, C. Masselon
Journal: Journal of Hepatology (2010)
Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?
Authors: Humberto Reyes, Rodrigo Zapata, Ismael Hernández, Martín Gotteland, Lorena Sandoval, María Isabel Jirón, Joaquín Palma, Ramón Almuna, Juan Jorge Silva
Journal: Hepatology (2006)

Increased gastrointestinal permeability has been demonstrated in several liver diseases. It may facilitate the absorption of gut-derived endotoxin-stimulating Kupffer cells to release proinflammatory cytokines or other potentially hepatotoxic compounds. We examined gastrointestinal permeability, plasma levels of anti-lipopolysacharides (anti-LPS), and four proinflammatory cytokines in 20 patients with intrahepatic cholestasis of pregnancy (ICP) compared with 22 normal pregnant and 29 non-pregnant women. Urinary excretion of sucrose and the urinary lactulose/mannitol (L/M) ratio after a standard oral load were used to assess gastrointestinal permeability. Anti-LPS (IgA, IgM, and IgG) were measured in peripheral blood by Human EndoCAb test kit; TNF-alpha, IL-1beta, IL-6, and IL-10 by Quantikine HS human immunoassays. Sucrose urinary excretion was similar in the three groups, indicating normal gastric permeability. The urinary L/M ratio was significantly higher in ICP than in the other groups [median (interquartile range): 0.018% (0.011-0.023) in ICP, 0.012% (0.009-0.016) in normal pregnancies, and 0.009% (0.008-0.012) in non-pregnant women, P < .01]. No significant differences were found in anti-LPS or cytokines plasma levels except slightly higher levels of IL-6 in ICP patients than in non-pregnant women (P < .05). Four of five women with abnormal urinary L/M ratio during ICP continued to show abnormalities in tests up to 2 years after delivery. In conclusion, an increased intestinal permeability was detected in ICP patients during and after pregnancy. A "leaky gut" may participate in the pathogenesis of ICP by enhancing the absorption of bacterial endotoxin and the enterohepatic circulation of cholestatic metabolites of sex hormones and bile salts.
IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer
Authors: Michael S. Anglesio, Joshy George, Hagen Kulbe, Michael Friedlander, Danny Rischin, Charlotte Lemech, Jeremy Power, Jermaine Coward, Prue A. Cowin, Colin M. House, Probir Chakravarty, Kylie L. Gorringe, Ian G. Campbell, Aikou Okamoto, Michael J. Birrer, David G. Huntsman, Anna de Fazio, Steve E. Kalloger, Frances Balkwill, C. Blake Gilks, David D. Bowtell
Journal: Clinical Cancer Research (2011)

Ovarian clear cell adenocarcinoma (OCCA) is an uncommon histotype that is generally refractory to platinum-based chemotherapy. We analyze here the most comprehensive gene expression and copy number data sets, to date, to identify potential therapeutic targets of OCCA.Gene expression and DNA copy number were carried out using primary human OCCA tumor samples, and findings were confirmed by immunohistochemistry on tissue microarrays. Circulating interleukin (IL) 6 levels were measured in serum from patients with OCCA or high-grade serous cancers and related to progression-free and overall survival. Two patients were treated with sunitinib, and their therapeutic responses were measured clinically and by positron emission tomography.We find specific overexpression of the IL6-STAT3-HIF (interleukin 6-signal transducer and activator of transcription 3-hypoxia induced factor) pathway in OCCA tumors compared with high-grade serous cancers. Expression of PTHLH and high levels of circulating IL6 in OCCA patients may explain the frequent occurrence of hypercalcemia of malignancy and thromboembolic events in OCCA. We describe amplification of several receptor tyrosine kinases, most notably MET, suggesting other potential therapeutic targets. We report sustained clinical and functional imaging responses in two OCCA patients with chemotherapy-resistant disease who were treated with sunitinib, thus showing significant parallels with renal clear cell cancer.Our findings highlight important therapeutic targets in OCCA, suggest that more extensive clinical trials with sunitinib in OCCA are warranted, and provide significant impetus to the growing realization that OCCA is molecularly and clinically distinct to other forms of ovarian cancer.
Unsolved problems in occupational dermatology
Authors: C.D. CALNAN
Journal: British Journal of Dermatology (1981)

Journal Article Unsolved problems in occupational dermatology Get access C.D. CALNAN C.D. CALNAN St John's Hospital for Diseases of the Skin, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s21, 1 September 1981, Pages 3–6, https://doi.org/10.1111/j.1365-2133.1981.tb01300.x Published: 01 September 1981
Tropical and Geographical Medicine
Authors: William M. Spira
Journal: JAMA (1984)

The sophisticated biomedical science and technology of the developed world have, in the past two decades, been increasingly applied to the important tropical and geographical diseases of the developing world. These efforts are providing new insights into host-parasite relationships at both the individual and population level and are offering many new means for the treatment and prevention of these diseases. This book attempts to draw these disparate elements into a meaningful guide for "all those who are studying, researching or practicing tropical or geographic medicine." The book is generally well written with a high degree of consistency between chapters that belies the large number of authors (153 contributors from 21 countries). Production values are high, but substantive editing errors do crop up occasionally (eg, Fig 112-2, in which an obviously incomplete legend fails to distinguish between marasmus and kwashiorkor in malnourished patients). The book's chief virtues are that it deals
Morphometric and Psychometric Comparisons between Non-Substance-Abusing Patients with Posttraumatic Stress Disorder and Normal Controls
Authors: Reza Emdad, David Bonekamp, Hans Peter Söndergaard, Tomas Björklund, Ingrid Agartz, Martin Ingvar, Töres Theorell
Journal: Psychotherapy and Psychosomatics (2006)

&lt;i&gt;Background:&lt;/i&gt; Hippocampal decrease in size in response to posttraumatic stress disorder (PTSD) is still a subject of controversy. The aims of this study were to: (1) confirm previous hippocampus findings in PTSD patients compared to controls, using ethnically similar study groups where alcohol and drug abuse were non-existent; (2) test influence of disease duration as well as depression scores on possible morphological changes; (3) test whether the voxel-based morphometry (VBM) data confirm the group differences seen in the region of interest (ROI) analysis, and (4) test the associations between the cognitive test scores and the morphological changes. &lt;i&gt;Methods:&lt;/i&gt; VBM and ROI-based analysis were applied in 23 patients and 17 healthy controls. Culture-neutral cognitive tests were used. &lt;i&gt;Results:&lt;/i&gt; The ROI-based method showed significantly decreased gray matter volumes for global hippocampal volume, as in a separate analysis of left and right sides in the PTSD group. Total volume of the hippocampus was significantly decreased on the left side, as in the global assessment. A multiple regression VBM model showed significant voxel clusters for group affiliation in the right hippocampus, modelling lowering of gray matter associated with the PTSD group. Disease duration was shown to be negatively correlated to bilateral hippocampal volume and high depression score to bilateral gray matter parahippocampal volume. No significant correlations were found between hippocampal or parahippocampal volumes and cognitive functions. &lt;i&gt;Conclusion:&lt;/i&gt; The present and previous studies showed that morphologic differences do not appear to be due to drug or alcohol abuse. The VBM data partially confirm the group differences seen in the ROI-based method in the medial temporal lobe. The fact that the significantly lower score on the short-term memory test in the PTSD group is not correlated to hippocampal volume may suggest a more general basis for such memory impairment.
Superannuation in the N.H.S
Authors: M. R. McNulty, R. S. McKim, P. M. Yeoman, P. G. Mann, K. R. Gough, J. K. Craig, C. D. Thomson, G. S. Wakefield, H. T. John, N. C. D. Pizey, T. L. Schofield, A. H. Young, S. Glaser
Journal: BMJ (1969)
ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot
Authors: Katarzyna Miśkiewicz, Liya E. Jose, André Bento-Abreu, Marcus Fislage, Ines Taes, Jarosław Kasprowicz, Jef Swerts, Stephan Sigrist, Wim Versées, Wim Robberecht, Patrik Verstreken
Journal: Neuron (2011)
Discharges from nursing homes
Authors: C E Bowman
Journal: BMJ (1994)

EDITOR, - In suggesting that their survey of discharges from nursing homes refutes the view that the NHS has become a dumping ground for increasingly dependent residents of such homes Jennifer M Henry and colleagues, perhaps accidentally, encourage policymakers and health commissioners to be complacent.1 The inadequacies of medical care for residents of nursing homes, with proved opportunities for treatment being missed, have been documented.2

The authors found that a quarter of …
Activation mapping of reentry around an anatomic barrier in the canine atrium. Observations during entrainment and termination.
Authors: P A Boyden, L H Frame, B F Hoffman
Journal: Circulation (1989)

We determined total right atrial activation sequences during entrainment and termination of flutter induced in dogs with a surgically induced atrial lesion. This type of atrial flutter is due to circus movement of an impulse around the tricuspid valve orifice. We recorded simultaneously from 96 bipolar intracavity electrodes in the right atrium of the isolated, perfused heart. By constructing isochronal maps, we demonstrated the pattern of atrial activation during atrial pacing protocols that either entrained or entrained and then terminated the reentrant rhythm. We show that during pacing the antidromic wavefront from the paced impulse (An) collides with the orthodromic wavefront from the previous paced impulse (On-1). During entrainment, the site of collision of the orthodromic and antidromic wavefronts was constant during pacing at a fixed rate but shifted in the antidromic direction as the pacing rate increased. Furthermore, the last paced beat was entrained only up to the site of collision of the previous paced beat. During one period of entrainment, termination of the reentrant arrhythmia occurred because On-1 blocked in the reentrant pathway due to refractory tissue left by On-2. However, subsequent An did not collide directly with On as was expected, but rather On blocked by an interaction with tissue left refractory by An. Because On was blocked, no reentry occurred when pacing ended.
Electrosleep—A Clinical Trial
Authors: SAUL H. ROSENTHAL, NORMAN L. WULFSOHN
Journal: American Journal of Psychiatry (1970)

Electrosleep is a technique of psychiatric treatment that has been undergoing development in the USSR for approximately 20 years, with a great flurry of interest in the past five years. The authors report briefly on a clinical evaluation of electrosleep in the United States to alert other investigators in this country to a new area of possible interest.
Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults
Authors: Jennifer S. Kim, Fengxiu Ouyang, Jacqueline A. Pongracic, Yaping Fang, Binyan Wang, Xue Liu, Houxun Xing, Deanna Caruso, Xin Liu, Shanchun Zhang, Xiping Xu, Xiaobin Wang
Journal: Journal of Allergy and Clinical Immunology (2008)
Differentiation of CD3-4-8- thymocytes in short-term thymic stromal cell culture.
Authors: A Sen-Majumdar, M Lieberman, S Alpert, I L Wiessman, M Small
Journal: The Journal of Experimental Medicine (1992)

We have investigated the ability of a heterogeneous thymic stromal cell (HTSC) culture system to promote in vitro differentiation of CD3-4-8- thymocytes. Culture of purified murine CD3-4-8- thymocytes on HTSC for 1 d resulted in the appearance of CD4+8+ cells, which did not occur when the sorted cells were maintained in medium alone. It is remarkable that when the culture period was extended to 2 d, CD3-4-8- progenitors differentiated further to CD4+8- and CD4-8+ cells, which also expressed high levels of TCR-CD3. This rapid differentiation on stroma in vitro appears to outpace parallel development in vivo. The differentiation potential of a subset of CD3-4-8- thymocytes that express high levels of a marker of normal and neoplastic thymic progenitors, the 1C11 antigen, was examined next. 1C11hiCD3-4-8- cells also gave rise to CD4-8+ and CD4+8+ populations after 1 d of culture on HTSC. Extending the culture period to 2 d resulted in a significant percentage of CD3-expressing cells that were CD4+8+, CD4+8- and CD4-8+ cells. These results suggest that in the in vitro HTSC culture system, various subsets of immature thymocytes can differentiate into all the mature phenotypes of cells normally found in the adult mouse thymus. This may provide a novel and rapid assay for thymic progenitors.
Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery
Authors: Qingmin Chen, David Butler, William Querbes, Rajendra K. Pandey, Pei Ge, Martin A. Maier, Ligang Zhang, Kallanthottathil G. Rajeev, Lubomir Nechev, Victor Kotelianski, Muthiah Manoharan, Dinah W.Y. Sah
Journal: Journal of Controlled Release (2010)
Decline in rehabilitation services
Authors: M. Lloyd, K. Mundy
Journal: Journal of the Royal Society of Medicine (2002)

Professor Grahame outlines the decline in rehabilitation services and its possible relation to the increase in disability benefits in the UK (March 2002 JRSM1). We agree that often the nearest a rheumatologist gets to rehabilitation is signing a benefits form and that patient care and the specialty may be the poorer for this. However, the phenomenon may have complex origins. The post-war period saw low unemployment levels and there was an expectation that the male of the family would be the breadwinner. With rising unemployment the job market has become more competitive and traditional gender roles have changed, perhaps ‘allowing’ more males to accept sickness roles. Litigation is more common and rising benefit claims may support Hadler's view that ‘if you have to prove you are ill, you can't get well’2. Rheumatology, like other specialties, is becoming more complex and many rheumatologists also have general medical responsibilities; rehabilitation may be an additional and intolerable burden.

The expanding specialty of elderly care may be partly bridging the service gap; in our area the lower age limit for admission to rehabilitation under the elderly-care multidisciplinary team is 18 years, and rheumatology patients, among many others, have greatly benefited from the service. In addition, the National Service Framework for Older People makes specific recommendations regarding the enhancement of access to rehabilitation and makes an attempt to end ageism in the provision of services, which should benefit young and old patients in the future.
Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation
Authors: Prasad Dasari, Sophia D. Heber, Maike Beisele, Michael Torzewski, Kurt Reifenberg, Carolin Orning, Anja Fries, Anna-Lena Zapf, Stefan Baumeister, Klaus Lingelbach, Rachanee Udomsangpetch, Sebastian Chakrit Bhakdi, Karina Reiss, Sucharit Bhakdi
Journal: Blood (2012)
Commentaries on the end of year editorial on the definition of ischaemia in last December's issue
Authors: K. Clarke
Journal: Cardiovascular Research (1995)

Journal Article Commentaries on the end of year editorial on the definition of ischaemia in last December's issue Get access Kieran Clarke, Dr Kieran Clarke, Dr Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 2, February 1995, Page 285, https://doi.org/10.1016/S0008-6363(95)90006-3 Published: 01 February 1995
Psychotherapeutic Drugs and Driving
Authors: LEO E. HOLLISTER
Journal: Annals of Internal Medicine (1974)

Editorial Notes1 March 1974Psychotherapeutic Drugs and DrivingLEO E. HOLLISTER, M.D.LEO E. HOLLISTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-3-413_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDrugs used to treat emotional disorders seem to be ubiquitous in these anxious times. The antianxiety drugs diazepam and chlordiazepoxide rank first and third, respectively, among prescribed drugs. Among the remaining top 50 favorite prescription drugs, one can count 13 others representing characteristic sedative-hypnotic, antipsychotic, and antidepressive drugs. Other drugs that have the potential to affect driving adversely may be prescribed, self-administered as over-the-counter remedies, or taken as social drugs. These include antihistaminics, analgesics, gastrointestinal drugs, sympathomimetics, caffeine, marihuana, and ethanol. The latter social drug is taken by approximately 50% of the population of the United States, roughly the same...References1. MILNER G: Drugs and Driving, vol. 1 of Monographs on Drugs, edited by AVERY GS. Basel, S. Karger AG, 1972 Google Scholar2. BETTSCLAYTONMACKAY TAG: Effects of four commonly used tranquilizers on low-speed driving performance tests. Br Med J 4:580-584, 1972 CrossrefMedlineGoogle Scholar3. HOLLISTER L: Uses of psychotherapeutic drugs. Ann Intern Med 79:88-98, 1973 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Hospital Stanford University School of Medicine Palo Alto, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-Induced Psychiatric Disorders and their ManagementBenzodiazepines as Drugs of Abuse and DependenceBehavioral Toxicity of Psychiatric Drugs 1 March 1974Volume 80, Issue 3Page: 413-413KeywordsAnalgesicsAntipsychoticsAnxiolyticsCaffeineDiazepamDrugsEmotionsEthanol Issue Published: 1 March 1974 PDF DownloadLoading ...
Avoiding becoming the English Medical Journal
Authors: R. Smith
Journal: BMJ (1999)

Personal view p 1221 

My wife is Scottish, making my children half Scottish, I'm a graduate of Edinburgh Medical School and a fellow of the Royal College of Physicians of Edinburgh, I breathe more deeply when I'm in Scotland, the bagpipes make me weep, and often “My heart is in the Highlands a-chasing of the deer,” but I fear that—viewed from Edinburgh—the British Medical Journal could become the English Medical Journal in devolving Britain.

“It already is,” say some Scots, although ironically the BMJ is the best read publication among Scottish general practitioners, while it comes third to two free newspapers in England (confirming in my mind the superior taste of the Scots). The view of the BMJ from Cardiff may not see it as quite so foreign, but the Welsh regret that many interesting health innovations in Wales don't make it into the BMJ . The doctors in Northern Ireland are perhaps too used to being forgotten to complain and, I suspect, enjoy the 20 miles of cold sea that separate them from the mainland of Britain. But the BMJ wants to be useful to doctors in all parts of what is currently called the United Kingdom, …
Cancer in nuclear test veterans: Important questions unanswered
Authors: R Lawson
Journal: BMJ (1994)

antibodies, particularly their opsonising activity.Assays are available in our unit to measure the ability of patients' serum to opsonise pneumococci and enhance the ingestion of these organisms by phagocytes.These tests may supplement quanti- tative antibody tests in determining the need for reimmunisation.As pneumococcal vaccine contains capsular polysaccharide from only 23 serotypes of Streptococcus pneumoniae it does not provide full protection against pneumococcal septicaemia, and lifelong prophylaxis with antibiotics must be recommended.The reported incidence of pneu- mococcus that is resistant to penicillin, however, is over 40% in Spain,' which makes it crucial to recommend antibiotics resistant to penicillinase for high risk patients.Finally, Capnocytophage canimorsus must be added to the list of organisms of which people who have undergone splenectomy and have contact with animals should be aware.This organism can be transmitted by animal bites, especially dog bites, and can lead to septicaemia and death.It remains susceptible to penicillin.
Persistent acantholytic dermatosis and extensive lentiginous 'freckling': a new entity?: reply from authors
Authors: S.M. Cooper, S. Burge
Journal: British Journal of Dermatology (2005)

Journal Article Persistent acantholytic dermatosis and extensive lentiginous ‘freckling’: a new entity?: reply from authors Get access S.M. Cooper, S.M. Cooper Department of Dermatology, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, U.K. E‐mail: sm_nc@btopenworld.com Search for other works by this author on: Oxford Academic Google Scholar S. Burge S. Burge Department of Dermatology, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, U.K. E‐mail: sm_nc@btopenworld.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 1, 1 July 2005, Page 218, https://doi.org/10.1111/j.1365-2133.2005.06667.x Published: 01 July 2005
Intravenous Diazepam for Direct-current Cardioversion
Authors: K. Somers, R. F. Gunstone, A. K. Patel, P. G. D'Arbela
Journal: BMJ (1971)

The induction of anaesthesia with intravenous diazepam is a valuable contribution to the simpler use of cardioversion and is the method of choice because it is readily available for elective cardioversion. Fifty-six cardioversion procedures were carried out by this method in an African hospital. No special premedication or drug preparation was used. There were no hazards apart from transient apnoea in two patients and persisting amnesia in one patient.
The rise of Stalinism in the NHS
Authors: R. Smith
Journal: BMJ (1994)

Recently I sat at dinner between a senior nurse and a senior NHS manager, and much of the talk was of Stalinism in the NHS. These people were convinced that the NHS was becoming an organisation in which people were terrified to speak the truth. This opinion is heard time and time again, and everybody seems convinced that it is becoming worse. We thought that it would be …