tbuckley/cabot-search huggingface dataset:
Localization of Ga-67 Citrate in Plasma Cell Granuloma of the Lung
Authors: WADE H. WONG, B RAMA RAO, THOMAS P. DRESSER, JAMES W. WINEBRIGHT
Journal: Clinical Nuclear Medicine (1979)

WONG, WADE H. L.CDR., M.C., U.S.N.R.; RAO, B RAMA CDR., M.C., U.S.N.; DRESSER, THOMAS P. L.CDR., M.C., U.S.N.R.; WINEBRIGHT, JAMES W. CDR., M.C., U.S.N. Author Information
THE ADULT WITH CONGENITAL HEART DISEASE IN A CORONARY CARE UNIT: CLINICAL CHARACTERISTICS AND OUTCOME
Authors: Álvaro Contreras, Hector Gonzalez-Pacheco, Alexandra Arias-Mendoza, Carlos Martinez, Jose Briseño, Amada Alvarez, Francisco Azar Manzur, Julio Sandoval
Journal: Journal of the American College of Cardiology (2014)
Low Molecular Weight Dextran Infusions in Systemic Sclerosis with Raynaud's Phenomenon: A Report of Nine Cases
Authors: P. Lane
Journal: BMJ (1970)

Two litres of low molecular weight dextran in normal saline were given intravenously over 48 hours to 10 patients with systemic sclerosis and Raynaud's phenomenon. The finger temperatures of nine were recorded under standardized conditions. One patient had lowered temperatures of the fingers, two had a rise in temperature, and six had no change. There were no side effects of the treatment. None of the 10 patients showed any clinical improvement.
Tissue and Species Distribution of mRNA for the i <sub>kr</sub> -like K <sup>+</sup> Channel, ERG
Authors: Randy S. Wymore, Gary A. Gintant, Rigel T. Wymore, Jane E. Dixon, David McKinnon, Ira S. Cohen
Journal: Circulation Research (1997)

The human K+ channel gene, HERG, has been linked to the type 2 form of the autosomal dominant long-QT syndrome and has been suggested to encode the fast component of the delayed rectifier K+ current (IKr) found in heart. To date, the published electrophysiological and pharmacological data on the Xenopus-expressed HERG are very similar but are not identical to those of the endogenous IKr. In an effort to provide a different type of correlative data on the relationship between erg and IKr. cDNA fragments of erg homologues from guinea pig, rabbit, human, dog, and rat were cloned and used to test for the presence of erg mRNA in cardiac tissue. RNase protection assays reveal that erg message is found in the hearts of all five species and that it is expressed uniformly throughout the heart. The erg transcript is expressed at relatively high levels, being approximately 50% more abundant than the most prevalent Kv-class K+ channel transcript in canine ventricle (Kv4.3) erg transcripts were found to have a wide tissue distribution in rat and are abundant in the brain, retina, thymus, and adrenal gland and are also found in skeletal muscle, lung, and cornea. Since there were no published reports of an IKr-like current in the rat heart, electrophysiological studies were performed to test whether the significant level of erg message in rat heart was correlated with the presence of an IKr-like current in rat. In isolated rat ventricular myocytes, an E-4031-sensitive current was observed, which is consistent with the presence of IKr. These results strengthen the link between erg and the native IKr in heart and suggest that erg may play an important role in other noncardiac tissues.
Abstract 1493: Tumor-associated soluble uPAR enhances endothelial cell migration by staffing into lipid rafts
Authors: Chandramu Chetty, Sajani S. Lakka, Praveen Bhoopathi, Shivani Ponnala, Jasti S. Rao
Journal: Cancer Research (2011)

Abstract The expression of urokinase plasminogen activator receptor (uPAR), a heavily glycosylated glycosyl-phosphatidylinositol (GPI)-anchored cell surface receptor, induces cell migration, and its expression correlates with the malignant phenotype of various cancers. The soluble form of uPAR (s-uPAR), which is found in the circulation of cancer patients, is associated with tumor malignancy and serves as a prognostic marker for various cancers. As such, in the current study, we analyzed the effect of s-uPAR from glioblastoma tumor cell conditioned medium (TCM) on endothelial cell migration. Here, we present evidence that s-uPAR from tumor cells augments migration and invasion on vitronectin and fibronectin matrices of human umbilical vein endothelial cells (HUVEC). The membrane fraction of HUVEC, which were cultured on TCM, had increased amounts of s-uPAR recruited into the membranes of endothelial cells. Co-localization studies for GM1 ganglioside receptor (a lipid raft marker) and uPAR further demonstrated s-uPAR recruitment into lipid rafts of HUVEC. Further, western blot analysis for uPAR in lipid raft fractions from HUVEC cells grown on TCM confirmed s-uPAR recruiting onto HUVEC cell membranes. Moreover, the addition of functional blocking uPAR antibodies to TCM mitigated s-uPAR-enhanced HUVEC migration and invasion. Our data suggest that s-uPAR from tumor cells might be involved in the recruitment of endothelial cells in the tumor microenvironment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1493. doi:10.1158/1538-7445.AM2011-1493
Trial starts of malaria vaccine in 2000 children in Mozambique
Authors: A. Gulland
Journal: BMJ (2003)

Researchers hope to see the first results from the largest ever malaria vaccine trial in children in Africa in just 18 months, the research team leader announced last week.

Phase two clinical trials of the most advanced malaria vaccine were due to start last Monday in 2000 children aged between 1 and 4 years in Mozambique.

Pedro Alonso, head of the Centre for International Health at the University of Barcelona, Spain, and principal investigator of the vaccine trial, told a press conference earlier this week: “The screening of the children has been completed, and we hope to have the results one and a …
Ankylosing hyperostosis: a study of HLA A, B, and C antigens.
Authors: J D Perry, H Wolf, H Festenstein, G O Storey
Journal: Annals of the Rheumatic Diseases (1979)

HLA A, B, and C antigens were studied in 25 patients with ankylosing hyperostosis. There was no evidence of an increased frequency of any antigen in association with the condition itself. However, a high frequency of several antigens was found, reflecting the predominance of Jewish patients in the series.
Progression of Systolic Abnormalities in Patients With “Isolated” Diastolic Heart Failure and Diastolic Dysfunction
Authors: Cheuk-Man Yu, Hong Lin, Hua Yang, Shun-Ling Kong, Qing Zhang, Steven Wai-Luen Lee
Journal: Circulation (2002)

Background — The definition of diastolic heart failure (DHF) relies on the use of sensitive tools to exclude the presence of systolic dysfunction. The use of ejection fraction (EF) of 50% as the cutoff point may not be adequate to address such a task. We believe that systolic dysfunction is common in DHF. Methods and Results — Echocardiography with tissue Doppler imaging was performed in 339 subjects, of whom 92 had systolic heart failure (SHF) (EF&lt;50%), 73 had DHF (EF≥50% with diastolic abnormalities on Doppler echocardiography), and 68 had isolated diastolic dysfunction (DD); 106 were normal control subjects. Regional myocardial velocity curves were constructed off-line with the use of a 6-basal, 6-midsegmental model. The peak regional myocardial sustained systolic (S M ) and early diastolic (E M ) velocities were significantly lower in patients with SHF, DHF, and DD than in control subjects in almost all the myocardial segments. Likewise, the mean S M (SHF&lt;DHF&lt;DD&lt;control subjects; 3.3±1.0&lt;4.6±1.3&lt;5.4±1.0&lt;6.3±1.0 cm/s; all P ≤0.001) and mean E M (SHF=DHF&lt;DD&lt;control subjects; 3.6±1.2 =3.9±1.3&lt;5.3±1.6&lt;7.2±1.7 cm/s; all P &lt;0.001) from the six basal segments were decreased in all the disease groups. A mean S M of 4.4cm/s (−2 SD of control subjects) predicted the presence of systolic dysfunction in 92% of patients with SHF, 52% with DHF, and 14% with DD. Conclusions — Through the use of tissue Doppler imaging, systolic abnormalities were evident in patients previously labeled as DHF and to a much lesser extent, isolated DD. This indicates the common coexistence of systolic and diastolic dysfunction in a spectrum of different severity in the pathophysiological process of heart failure.
Sudden Appearance of Cardiac Arrhythmias After Dexamethasone
Authors: Gwendolyn B. Schmidt
Journal: JAMA (1972)

A 43-years-old woman was given 100 mg of dexamethasone intravenously the evening after aortic and mitral valve replacement. Immediately thereafter she developed very frequent multifocal premature ventricular contractions which subsided with the intravenous administration of lidocaine (Xylocaine 2%). Later she was given 50 mg of dexamethasone intravenously, and the arrhythmias recurred. The pathogenesis of these severe arrhythmias in this already stressed myocardium is uncertain. There is a possibility that it might be due to the preservatives.
ABSENCE OF MONOCLONAL-ANTIBODY-DEFINED PROTEIN COMPLEX IN BOY WITH ABNORMAL LEUCOCYTE FUNCTION
Authors: PatrickG. Beatty, JohnM. Harlan, Henry Rosen, JohnA. Hansen, HansD. Ochs, ThomasH. Price, RobertF. Taylor, SeymourJ. Klebanoff
Journal: The Lancet (1984)
Correlation between MET Gene Copy Number by Silver In Situ Hybridization and Protein Expression by Immunohistochemistry in Non-small Cell Lung Cancer
Authors: Rafal Dziadziuszko, Murry W. Wynes, Shalini Singh, Bernadette Reyna Asuncion, James Ranger-Moore, Krzysztof Konopa, Witold Rzyman, Barbara Szostakiewicz, Jacek Jassem, Fred R. Hirsch
Journal: Journal of Thoracic Oncology (2012)
END-ORGAN RESISTANCE TO 1,25-DIHYDROXYCHOLECALCIFEROL
Authors: U.A. Liberman, A. Halabe, R. Samuel, R. Kauli, S. Edelstein, Y. Weisman, S.E. Papapoulos, L.J. Fraher, T.L. Clemens, J.L.H. O'Riordan
Journal: The Lancet (1980)
Is Radiological Hand Osteoarthritis Associated with Atherosclerosis?: A Cross-Sectional Study in Turkish Women
Authors: Muhammed Bora Demirçelik, Halıl Ibrahım Aydın, Ozlem Cemeroglu, Zeynep Sıla Yasar, Ozgul Malcok Gurel, Fadime Bozduman, Yusuf Selcoki, Beyhan Eryonucu
Journal: Journal of the American College of Cardiology (2013)
Denying HIV Safe Haven
Authors: Warner C. Greene
Journal: New England Journal of Medicine (1996)

The ability of the human immunodeficiency virus (HIV) to replicate successfully in vitro appears inextricably linked to the state of activation of its cellular host. Indeed, an activated cellular environment is crucial for both the initial phase of the HIV life cycle involving reverse transcription and the establishment of the HIV provirus within the host chromosome and the subsequent expression of these proviral genes and the directed assembly of infectious virions.1 Hints that the state of cellular activation is just as important for viral replication in vivo emerged when viral gene expression was preferentially detected in the germinal centers of . . .
Osler on Listening to the Patient
Authors: HILTON S. READ
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 January 1970Osler on Listening to the PatientHILTON S. READ, M.D.HILTON S. READ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-1-144 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Thanks for Baltimore and clinical medicine in the June 1969 ANNALS. In 1923 as an intern at the Philadelphia General Hospital I came under the influence of some spectacular clinicians, and the heritage of the Osler aura was still present. Rummaging through Leary's second-hand bookstore in Philadelphia I came across Osler's "Æquanimitas," which now is almost falling apart, but still holds a central position in my office. Each year I give to the "graduating" interns of the Atlantic City Hospital a copy of his "A Way Of Life," which he delivered to the Yale students on the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ventnor Diagnostic Center 5407 Atlantic Ave. Ventnor City, N.J. 08406 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1970Volume 72, Issue 1Page: 144-145KeywordsEpilepsy Issue Published: 1 January 1970 PDF downloadLoading ...
The Frontal Plane Vectorcardiogram in Old Inferior Myocardial Infarction
Authors: ELIOT YOUNG, HAROLD D. LEVINE, PANTEL S. VOKONAS, HARVEY G. KEMP, RICHARD A. WILLIAMS, RICHARD GORLIN
Journal: Circulation (1970)

The mid-to-late part of the frontal plane QRS loop (Frank lead system) of 150 consecutive subjects with an old inferior myocardial infarction was analyzed. During the acute episode all cases had to satisfy Myers' classical ECG criteria for the diagnosis. The vectorcardiogram was recorded months to years later. As a result of this analysis and in order to prevent overlap with values found in 450 normal control subjects, four VCG criteria are proposed for this diagnosis. The VCGs of 75 of the 150 patients fulfilled one or more of the four VCG criteria. The ECG, done at the time of VCG, satisfied Myers' or Goldberger's criteria or both criteria in 33 of these 75 patients, and an additional 24 of the 150 fulfilled either or both of these ECG criteria but had none of the four VCG criteria. Among 131 consecutively catheterized subjects who had significant disease of one or more major coronary arteries, 40 fulfilled one or more of the VCG criteria. Thirty-six of the 40 showed significant stenosis of at least the right coronary artery, and the other four, of at least the left circumflex but not of the right coronary artery. Six of these 40 fulfilled Myers' or Goldberger's criteria. Five of the 131 fulfilled either or both of these ECG criteria but none of the four VCG criteria.
Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10.
Authors: J P Rapp, M R Garrett, A Y Deng
Journal: Journal of Clinical Investigation (1998)

Previously we presented suggestive evidence from an F2 segregating population for an interaction on blood pressure (BP) between quantitative trait loci (QTL) on rat chromosomes (Chr) 2 and 10. To prove the existence of such an interaction, we developed congenic strains for Chr 2 and 10 by introgressing the low BP QTL alleles into the Dahl salt-sensitive (S) strain. A double congenic strain was also constructed with both the Chr 2 and 10 low BP QTL alleles on the S background. The four strains (S, Chr 2 congenic, Chr 10 congenic, and Chr 2/10 double congenic) were studied for BP response to increased salt intake. An analysis of variance showed significant main effects of Chr 2, Chr 10, and a significant interaction between Chr 2 and 10 on BP and heart weight (all P < 0.0001). The interaction accounted for 24 mmHg of BP and 79 mg of heart weight. Thus, the discovery and proof of epistatic interactions are clearly critical to understanding the genetics of blood pressure.
THE EFFECTS OF 1-HYDRAZINOPHTHALAZINE UPON CORONARY HEMODYNAMICS AND MYOCARDIAL OXYGEN METABOLISM IN ESSENTIAL HYPERTENSION 1
Authors: George G. Rowe, John H. Huston, George M. Maxwell, Arvin B. Weinstein, Herman Tuchman, Charles W. Crumpton, Beryl E. Welch, Audrey L. Peterson
Journal: Journal of Clinical Investigation (1955)
The Attraction of Mosquitoes to Hosts
Authors: Anthony W. A. Brown
Journal: JAMA (1966)

When a man is standing in mosquito-infested territory in a light breeze, the mosquitoes will pass him by, but those which enter the downwind cone of his emanations will turn and work upwind to him from as much as 30 feet away, as closely observed by Hocking 1 of Aedes dorsalis on the Alberta prairie. When a man is standing in a closed room, the mosquitoes in flight alongside ignore him, but let him lie down and he will activate all those which experience the ascending convection currents above him, as found by Mer et al 2 for Anopheles sacharovi in Israel. The photographs obtained by Kellogg and Wright 3 for Ae aegypti exposed to a smoke-marked moving cone of warm, moist air show that these avid females proceed upwind to its source by a behavioral response known as anemotaxis, supplemented by klinokinesis on the boundary of the cone that
The Male Prepuce
Authors: Hans Schroeder
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The case of the male prepuce is well stated by Dr. Smatko (<i>JAMA</i><b>175</b>:1186 [April 1] 1961). However, circumcision is not done in a uniform manner everywhere. Riedel reports (<i>Das Weib in der Natur-und Völkerkunde</i>, vol. 2, Leipzig: Ploss &amp; Bartels, 1891) that adolescent boys of the Serang Islands (East India) let themselves be circumcised Malayan style upon the urging of their girl friends. In this circumcision, only about one-third of the prepuce is removed on the dorsal side. The Aruntas of central Australia also practice circumcision; the reason for this is not given. It appears that this and worse mutilations of the penis are done to increase the lust of women, and mostly on their insistence. Religious rites are not mentioned. The Jewish religion is unique in that there is no mention of human sacrifice. The story of Jacob's ladder is the only place in
Vital Signs: A Young Doctor's Struggle With Cancer
Authors: Tony Miksanek
Journal: JAMA (1984)

<i>Vital Signs</i>is the story of a healthy, active 32-year-old physician who is suddenly and disturbingly transformed into a patient with cancer. It is an autobiographical account of the author's discovery of a clinically silent tumor on his routine chest roentgenogram and the catastrophic events that follow, including a vivid description of his thoracotomy, radiation treatments, and chemotherapy. The book explores a young physician's physical, emotional, and mental struggle, from his diagnosis of cancer to his theoretical cure. The author, Fitzhugh Mullan, is former director of the National Health Service Corps and is now Chief Medical Officer, Office of Medical Applications of Research, National Institutes of Health. This struggle takes many forms, including the ability to cope with possible tumor recurrence or death, side effects of various cancer treatment regimens, interactions with family and friends, and a return to normalcy. Perhaps the most important question the book poses is how
Election 2008 — Campaign Contributions, Lobbying, and the U.S. Health Sector
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (2007)

Between January and June 2007, the presidential candidates raised more than $265 million, representing the fastest start to presidential fund-raising ever. Dr. Robert Steinbrook writes that, so far, only a small percentage of the contributions has come from people who are affiliated with the health sector.
Effect of Propranolol on Myocardial Oxygen Consumption and Its Hemodynamic Correlates during Upright Exercise
Authors: CHARLES R. JORGENSEN, KYUHYUN WANG, YANG WANG, FREDARICK L. GOBEL, RICHARD R. NELSON, HENRY TAYLOR, Frank R. Gams, John E. Vilandre
Journal: Circulation (1973)

Measurements were made of heart rate, aortic blood pressure, systolic ejection period/beat, myocardial blood flow, and myocardial oxygen consumption in nine normal young men during three bouts of upright bicycle exercise: 1) at the workload which produced a heart rate of 120 beats/minute, 2) at the higher workload necessary to produce a heart rate of 120 beats/minute after administration of intravenous propranolol 0.25 mg/kg, and 3) with infusion of propranolol, at the same workload as the first exercise bout. Comparing exercises 1 and 2, we found a much higher workload was required to produce the same heart rate after propranolol. The blood pressure, heart rate-blood pressure product, and myocardial oxygen consumption were the same despite the much greater level of exertion. Comparing exercises 1 and 3, the heart rate, blood pressure, heart rate-blood pressure product, and myocardial oxygen consumption were all significantly lower during exercise 3 after propranolol despite the fact that the same degree of exercise was being done. As in previous studies, the heart rate-blood pressure product was an excellent correlate of myocardial oxygen consumption despite the change in contractility induced by propranolol. The systolic ejection period was prolonged significantly altering the tension-time index (TTI), which became an inadequate index of myocardial oxygen consumption. It is concluded that the heart rate-blood pressure product is a good index of myocardial metabolic needs during exercise and the relationship is undistorted by marked changes in contractility, but the tension-time index is a poor correlate. This data emphasizes the fact that the relative metabolic loads for the whole body and for the heart are determined separately and may not change in parallel with a given intervention.
Perinatal Pharmacology and Therapeutics
Authors: R S Illingworth
Journal: BMJ (1976)

Malignancy is now the commonest disease causing death in children over the age of 1 year.At a time when encouraging results in the treatment of some childhood malignancies are being reported this book provides a timely, succinct, but accurate and well- informed survey of the current position.Its authors are distinguished American paediatricians and oncologists, to whom we owe much of the modern concept of a team approach by a paediatrician, oncologist, surgeon, and radiotherapist in the management
Preventing severe infection after splenectomy
Authors: Adrian Newland, Drew Provan, Steven Myint
Journal: BMJ (2005)

Patients should know the risks, be immunised, and take prophylactic antibiotics 

S plenectomy may be followed by severe systemic infection because such surgery removes the splenic macrophages that filter and phagocytose bacteria and other bloodborne pathogens. Overwhelming post-splenectomy infection (OPSI), as this complication is called, is uncommon but has high mortality.

Overwhelming post-splenectomy infection is usually caused by the encapsulated bacteria Streptococcus pneumoniae, Haemophilus influenzae , and Neisseria meningitidis and more than half of those infected die.1 Other pathogens in such infection may include bacteria such as Escherichia coli and Pseudomonas aeruginosa ,2 Capnocytophagia canimorsus , group B streptococci, Enterococcus spp, Ehrlichia spp, and protozoa such as the Plasmodium spp leading to malaria.

The first description of overwhelming post-splenectomy infection was published by King and Schumaker in 1952.3 The disease may begin as a minor flu-like illness that rapidly escalates into a fulminant infection.2 It is most common in the first two years after splenectomy but may occur decades later.4 Its true incidence is not …
THE VALUE OF WEAK CYLINDERS FOR THE RELIEF OF EYE MUSCLE STRAIN.Read in the Section on Ophthalmology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C. May, 1891.
Authors: JULIAN J. CHISOLM
Journal: JAMA (1891)

Three years ago I read a paper before the ophthalmological section of the American Medical Association, on the value of 0.25 D. cylinder in the correction of the lesser grades of astigmatism. My additional experience confirms the position which I then took. The annoyance occasioned by eye muscle strain demands recognition from complaining patients whose heads will ache when the eyes are much used. All astigmatic eyes do not suffer in like proportion. There are three factors at work that bring about annoyance. The first is the amount of eye work required by a badly shaped cornea; a second factor is the degree of fault; and a third is found in the nervous susceptibility of the patient. As to the first condition, the amount of work required. The majority of astigmatic eyes only exhibit the trouble under forced application. Eyes which have done faithful and painless duty for many years