tbuckley/cabot-search huggingface dataset:
Abstract 2506: Histology-directed lipid MALDI MS profiling can distinguish prostate cancer from normal epithelium.
Authors: Seungho Choi, Jun Won Park, Weon Seo Park, Hark Kyun Kim, Kang Hyun Lee
Journal: Cancer Research (2013)

Abstract Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is demonstrated to be useful for profiling of common solid tumors. In this approach, mass spectra are obtained from discrete locations on 10 μm-thick cryosection tissue, guided by H&amp;E-stained top slide. To determine if a lipid signature obtained from tissue samples could be found to assist with diagnosis, frozen surgical samples collected from 7 prostate cancer patients and 9 adjacent normal tissue samples were analyzed using matrix (DHB/CHCA)-assisted laser desorption/ionization (MALDI) mass spectrometry (MS). When leave-one-out cross validation was performed using support vector machine, permutation p value for the cross-validated misclassification rate was statistically significant (p=0.04), suggesting that lipid profiles are clearly different between prostate cancer and adjacent normal tissue samples. One of the most striking difference between prostate cancer and normal tissue is the phosphatidylcholine (PC) 32:1 (m/z 798.6) overexpression (p=0.007, tumor/normal=2.4). In order to identify molecular mechanisms of PC 32:1 overexpression in prostate cancers, we performed immunohistochemical analyses for metabolic enzymes responsible for phosphatidylcholine biosynthesis. Prostate cancers overexpress choline kinases and phosphate cytidylyltransferases, known oncogenes which generate phosphatidylcholines, compared with adjacent normal tissue samples. Thus, lipid MALDI MS analysis captures a global alteration in lipid profile of prostate cancer tissue, potentially distinguishing cancerous epithelium from normal epithelium. To our knowledge, this study is the first comprehensive lipid profiling study in prostate cancer. This histology-directed MALDI MS approach enables rapid and sensitive identification of discriminatory lipids in cancerous epithelium of prostate cancers, even those with infiltrative growth. We are in the process of a large sample set (Supported by Korean Ministry of Education, Science, and Technology Grant 2012K001506). Citation Format: Seungho Choi, Jun Won Park, Weon Seo Park, Hark Kyun Kim, Kang Hyun Lee. Histology-directed lipid MALDI MS profiling can distinguish prostate cancer from normal epithelium. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2506. doi:10.1158/1538-7445.AM2013-2506 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Serum biochemical markers of liver fibrosis in human immunodeficiency virus (HIV) and hepatitis C virus (HCV)-coinfected patients
Authors: Robert P. Myers, Yves Benhamou, Marie Bochet, Francoise Imbert-Bismut, Vincent Thibault, Vlad Ratziu, Frederic Charlotte, Christine Katlama, Thierry Poynard
Journal: Journal of Hepatology (2002)
Localization of the Aortic Valve by Intracavitary Electrocardiography
Authors: WILLIAM L. UNDERHILL, HERMAN K. HELLERSTEIN, JOHN B. TREDWAY, GEORGE J. D'ANGELO
Journal: Circulation (1964)

The intracavitary electrocardiogram was studied in the aortic outflow tract during left heart catheterization to determine its usefulness in accurately locating the aortic valve. Twenty-eight of 31 cases studied showed a significant electrocardiographic change at the valve which was not observed elsewhere. Changes noted included decrease in QRS voltage, qualitative QRS change, and P-wave change. The routine use of the intracardiac electrocardiogram in conjunction with other technics is advocated.
Book Review “Letting Them Die”: Why HIV/AIDS Prevention Programmes Fail (African Issues.) By Catherine Campbell. 214 pp. Bloomington, Indiana University Press, in association with the International African Institute, 2003. $49.95 (cloth); $22.95 (paper). 0-253-34328-3 (cloth); 0-253-21635-4 (paper).
Authors: Keith E. Hansen
Journal: New England Journal of Medicine (2004)
The κ opioid system regulates endothelial cell differentiation and pathfinding in vascular development
Authors: Kohei Yamamizu, Sadayoshi Furuta, Shiori Katayama, Michiko Narita, Naoko Kuzumaki, Satoshi Imai, Hiroshi Nagase, Tsutomu Suzuki, Minoru Narita, Jun K. Yamashita
Journal: Blood (2011)
Youngsters Dialing Up Cholesterol Levels?
Authors: Marsha F. Goldsmith
Journal: JAMA (1990)

COUCH POTATOES—or at least the younger spuds—got mashed again at the recent American Heart Association meeting. In Dallas, Tex, pediatric researchers from the University of California, Irvine, School of Medicine, reported that they had found an "amazing correlation" between television watching and high blood cholesterol levels in young persons 2 to 20 years of age. The findings were presented by Thomas K. Hei, a premedical student at the school. Hei was a coinvestigator with Kurt V. Gold, MD, a resident in pediatrics; Nathan Wong, MD, assistant adjunct professor of medicine; and Paul Qaqundah, MD, chair of the School Health and Education Committee of the American Academy of Pediatrics' Southern California chapter. The study was done to evaluate risk factors as indicators for elevated blood cholesterol concentrations in children. Cooperating Southern California pediatricians screened 543 boys and 523 girls and found blood cholesterol levels of 5.15 mmol/L or higher (≥200 mg/dL)
Falls and Fractures With Atypical Antipsychotic Medication Use
Authors: Lisa-Ann Fraser, Kuan Liu, Kyla L. Naylor, Y. Joseph Hwang, Stephanie N. Dixon, Salimah Z. Shariff, Amit X. Garg
Journal: JAMA Internal Medicine (2015)

pared with never users.Cumulative use was not associated with increased odds of acute pancreatitis (P for trend among users = .49).Use of other antiarrhythmic drugs was not associated with acute pancreatitis (Table 2).Discussion | In this study of health care utilization data, use of amiodarone but not of other antiarrhythmic drugs was associated with a 50% increased odds of acute pancreatitis among patients with NVAF.The odds were almost doubled in the 12 months after amiodarone therapy initiation and did not depend on cumulative use of amiodarone.Considering an incidence of acute pancreatitis of 3 to 4 cases per 10 000 adults per year, 4 the observed association would result in approximately 1 to 2 additional cases of acute pancreatitis per 10 000 amiodarone users per year.A few isolated case reports of acute pancreatitis possibly linked to amiodarone use have been described in the literature. [1]2][3] The mechanisms responsible for this association are unknown, although direct cytotoxicity or immune-mediated pathways, as described for amiodarone-related pulmonary toxic effects, could be potential explanations. 5 Strengths of our study include the prospective assessment of medication use, the large sample size, and the availability of information on comorbidities and use of other medications potentially associated with increased risk of acute pancreatitis.Limitations are related to the use of health care utilization data: limited information on the validity of claims for acute pancreatitis, absence of clinical variables that characterize severity of the episode (eg, blood markers of acute pancreatitis), and the select group of patients included in this database.Our results indicate that acute pancreatitis could be an adverse effect of amiodarone use, an effect that may not be shared by other antiarrhythmic drugs.Even though the absolute risk of acute pancreatitis in the general population is low, health care professionals should be aware of this potential association in the treatment of patients with NVAF or acute pancreatitis.Further research should replicate our findings and determine potential mechanisms.
REPORT OF TWO CASES OF MALIGNANT ENDOCARDITIS.
Authors: JAMES F. PRESSLEY
Journal: JAMA (1906)

<h3>Case 1.</h3> —F. D., boy, aged 16. <h3>History.</h3> —Both of his parents are alive and well. The boy had always been well up to a month before entering St. Thomas Hospital. At that time he contracted an attack of gonorrhea and about a week later suffered from what was considered la grippe, with throat symptoms predominating. The illness which brought him to the hospital was diagnosed typhoid fever and was of about a week's duration. He had pains in his back and head, fever and delirium. <h3>Examination.</h3> —Physical examination showed a well-developed and well-nourished boy. He was partly delirious and very apathetic. Pulse was 110, temperature 103.6. The eyes reacted to light and to accommodation. The tongue was flabby and coated. The lungs were negative. Examination of the heart showed diffuse, forcible pulsation visible over the whole heart area, and more pronounced at the apex. This pulsation was also readily
Anticoagulant synergism of heparin and activated protein C in vitro. Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C.
Authors: J Petäjä, J A Fernández, A Gruber, J H Griffin
Journal: Journal of Clinical Investigation (1997)

Interactions between standard heparin and the physiological anticoagulant plasma protein, activated protein C (APC) were studied. The ability of heparin to prolong the activated partial thromboplastin time and the factor Xa- one-stage clotting time of normal plasma was markedly enhanced by addition of purified APC to the assays. Experiments using purified clotting factors showed that heparin enhanced by fourfold the phospholipid-dependent inactivation of factor V by APC. In contrast to factor V, there was no effect of heparin on inactivation of thrombin-activated factor Va by APC. Based on SDS-PAGE analysis, heparin enhanced the rate of proteolysis of factor V but not factor Va by APC. Coagulation assays using immunodepleted plasmas showed that the enhancement of heparin action by APC was independent of antithrombin III, heparin cofactor II, and protein S. Experiments using purified proteins showed that heparin did not inhibit factor V activation by thrombin. In summary, heparin and APC showed significant anticoagulant synergy in plasma due to three mechanisms that simultaneously decreased thrombin generation by the prothrombinase complex. These mechanisms include: first, heparin enhancement of antithrombin III-dependent inhibition of factor V activation by thrombin; second, the inactivation of membrane-bound FVa by APC; and third, the proteolytic inactivation of membrane-bound factor V by APC, which is enhanced by heparin.
A man with bloody diarrhoea
Authors: J. W. Hinton, J. R. F. Cummings
Journal: BMJ (2012)

A 32 year old man with known ulcerative colitis and ankylosing spondylitis was admitted with diarrhoea (at least eight stools per 24 hours) mixed with blood and mucus. He also had lower abdominal pain, lethargy, and was feeling feverish. On examination he was afebrile, had a pulse of 90 beats/min, and was tender in his left iliac fossa. Blood tests on admission showed haemoglobin 111 g/L (reference range 120-150), platelets 453×109/L (150-400), international normalised ratio 1.5, C reactive protein 205 mg/L (0-7.5), sodium 127 mmol/L (136-144), potassium 3.6 mmol/L (3.5-5.0), albumin 25 g/L (35-48).

On admission he was taking balsalazide 2.25 g three times daily for stable ulcerative colitis. He had never been admitted to hospital for ulcerative colitis and had not received antibiotics.

The patient underwent flexible sigmoidoscopy, which showed severe ulceration in the rectum.

On day 3 he was passing stools—which were mixed with blood—six times a day, he was still tender in his right iliac fossa, and he had a temperature of 38°C. His C reactive protein was 119 mg/L.



### 1 What is the likely diagnosis, and what other diagnoses need to be considered in a patient with bloody diarrhoea?

#### Short answer

A relapse of ulcerative colitis is the most likely diagnosis, but other diagnoses that must be considered include infectious causes, ischaemic colitis, diverticular disease, and cancer.

#### Long answer

This is probably a flare of ulcerative colitis. Infectious causes should also be considered and excluded, including bacterial ( Clostridium difficile , Salmonella spp, Shigella spp, Campylobacter spp, Escherichia coli 0157, amoebae,1 2 and viruses such as cytomegalovirus. He could possibly have …
Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
Authors: Hagop M Kantarjian, Andreas Hochhaus, Giuseppe Saglio, Carmino De Souza, Ian W Flinn, Leif Stenke, Yeow-Tee Goh, Gianantonio Rosti, Hirohisa Nakamae, Neil J Gallagher, Albert Hoenekopp, Rick E Blakesley, Richard A Larson, Timothy P Hughes
Journal: The Lancet Oncology (2011)
Doctor who lied on his CV is allowed to return to work
Authors: C. Dyer
Journal: BMJ (2013)

An anaesthetist who falsely claimed credit for six research publications in his curriculum vitae and lied under oath at his General Medical Council (GMC) hearing has been allowed to return to work after a 12 month suspension from the medical register.

David Clark was working as a locum consultant at Crosshouse Hospital in Kilmarnock, Ayrshire, in May 2009 when he applied for a full time consultant job, attaching a CV that incorrectly named him as contributing author of six articles.

Although he was not shortlisted for the …
Hormone Changes in Aging Adults Probed
Authors: R. Trubo
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe Diabetic Ketoacidosis
Authors: Paul M. Beigelman
Journal: JAMA (1969)

Severe diabetic ketoacidosis is defined by us as a ketoacidotic state with serum bicarbonate decreased to levels of 10 mEq/liter or less. A synonymous term used in the past was "chemical diabetic coma." Although patients are often mentally obtunded and sometimes unconscious, these features are not essential components of the severe ketoacidotic state. Successful management is based on competent monitoring of the clinical and chemical status of the patient. A short-term study of 51 episodes of severe diabetic ketoacidosis in 46 patients admitted to our service, included in this presentation, has emphasized the importance of well-directed management in preventing fatal outcome. Other causes of metabolic acidosis must also be considered. Renal acidosis reflects the failure of the kidney to excrete acid metabolites. Lactic acidosis is due to an excess of lactic acid and usually accompanies tissue anoxia when oxidative metabolism cannot be sustained because of circulatory failure. Another disorder that
Cytodiagnostic use of Feulgen-DNA measurements in cell imprints from the skin of patients with mycosis fungoides
Authors: W. A. VLOTEN, P. DUIJN, A. SCHABERG
Journal: British Journal of Dermatology (1974)

To obtain objective criteria for the diagnosis of incipient mycosis fungoides, Feulgen-DNA cytophotometry was carried out in skin imprint preparations from patients with clinically definite mycosis fungoides and from patients suspected of having this disease. Cell imprints of benign skin lesions such as chronic dermatitis served as controls. All patients with mycosis fungoides showed abnormal histograms with aneuploid and polyploid Feulgen-DNA distribution patterns. In the control group the mean class of Feulgen-DNA values was diploid. Five per cent or more of non-diploid cells was taken as a criterion for malignancy. On this basis, eight of the fifteen patients in the suspect group showed abnormal histograms. Six of these eight patients developed a malignant skm reticulosis within a year. The other (seven) patients in this group showed normal histograms, and none of them developed a skin malignancy during a follow-up period of 2½ years. Feulgen-DNA cytophotometry may therefore be considered an objective aid in the diagnosis of the early stages of mycosis fungoides.
Very Low-Fat Diets for Coronary Heart Disease: Perhaps, But Which One?-Reply
Authors: K. Lance Gould
Journal: JAMA (1996)

<h3>In Reply.</h3> —The case described by Dr Siguel and colleagues raises 3 issues. Because of differing views, Dr Ornish and I respond separately. Frequently, triglyceride levels increase and HDL-C levels decrease for individuals on vegetarian, high-carbohydrate diets. Since low HDL-C, particularly with high triglycerides, incurs substantial risk of coronary events,<sup>1,2</sup>I do not recommend a high-carbohydrate strict vegetarian diet. Reducing carbohydrate and weight lowers triglyceride levels and raises HDL-C levels.<sup>3</sup> For this reason, my Program for Preventing or Reversing Coronary Heart Disease utilizes less than 10% of calories as fat, no-fat low-carbohydrate protein sources, low-carbohydrate sufficient to maintain lean body habitus, and volumes of vegetables for fiber and phytonutrients. These protein sources include no-fat yogurt, no-fat cheese, skim milk, no-fat cottage cheese, and egg whites or soy protein, supplemented optionally with some turkey, chicken, fish or buffalo/venison with cholesterol intake below 50 mg/d and 10% of calories as
Epidermodysplasia verruciformis-associated papillomavirus infection complicating human immunodeficiency virus disease
Authors: T.G. BERGER, W.S. SAWCHUK, C. LEONARDI, ANDRIA LANGENBERG, J. TAPPERO, P.E. LEBOIT
Journal: British Journal of Dermatology (1991)

Journal Article Epidermodysplasia verruciformis‐associated papillomavirus infection complicating human immunodeficiency virus disease Get access T.G. BERGER, T.G. BERGER Departments of Dermatology and Pathology, School of Medicine, University of California, San Francisco, CA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar W.S. SAWCHUK, W.S. SAWCHUK Laboratory of Cellular Oncology. National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar C. LEONARDI, C. LEONARDI Department of Dermatology, University of Miami, FL, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar ANDRIA LANGENBERG, ANDRIA LANGENBERG Departments of Dermatology and Pathology, School of Medicine, University of California, San Francisco, CA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J. TAPPERO, J. TAPPERO Departments of Dermatology and Pathology, School of Medicine, University of California, San Francisco, CA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar P.E. LEBOIT P.E. LEBOIT Departments of Dermatology and Pathology, School of Medicine, University of California, San Francisco, CA, U.S.A. Dr P.E. LeBoit. Department of Pathology. School of Medicine. University of Califirnia. San Francisco. CA. 94143‐0506 U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 1, 1 January 1991, Pages 79–83, https://doi.org/10.1111/j.1365-2133.1991.tb03286.x Published: 01 January 1991
Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE−/− mice
Authors: Juan Feng, Zhenmin Zhang, Wei Kong, Bo Liu, Qingbo Xu, Xian Wang
Journal: Cardiovascular Research (2009)

Atherosclerosis is an inflammatory disease with T cell-driven immunoinflammatory responses contributing to disease initiation and progression. We investigated the potential role of regulatory T cells (Tregs) in hyperhomocysteinaemia (HHcy)-accelerated atherosclerosis in apoE−/− mice. apoE−/− mice were fed normal mouse chow supplemented with or without a high level of homocysteine (Hcy) (1.8 g/L) in drinking water for 2, 4, and 6 weeks. Atherosclerotic lesion area was slightly increased at 2 weeks and substantially elevated at 4 and 6 weeks in HHcy apoE−/− mice. Cotransfer of normal Tregs significantly attenuated atherosclerotic lesion size and infiltration of T cells and macrophages into plaque. Furthermore, Treg cotransfer reversed HHcy-accelerated proliferation of T cells, -increased pro-inflammatory, and -decreased anti-inflammatory cytokine secretion from activated splenic T cells. With a clinically relevant level of plasma Hcy, the proportion of Tregs and suppressive activity in splenic T cells were reduced in HHcy apoE−/− mice, which was associated with reduced mRNA and protein expression of Foxp3, a factor governing mouse Treg development and function. In addition, Hcy significantly attenuated the proportion and suppressive effects of Tregs in vitro. HHcy suppresses the function of Tregs, which may be responsible for HHcy-accelerated atherosclerosis in apoE−/− mice.
The London OMED position statement for credentialing and quality assurance in digestive endoscopy
Authors: D. Faigel, P. Cotton
Journal: Endoscopy (2009)

Corrected by: The London OMED position statement for credentialing and quality assurance in digestive endoscopyEndoscopy 2010; 42(06): 502-502DOI: 10.1055/s-0029-1244246
Cocaine-Induced Incomplete Bundle Branch Block in Dogs
Authors: THOMAS B. WATT, RAYMOND D. PRUITT
Journal: Circulation Research (1964)

Cocainization of a segment of the right or left bundle branch in the canine heart permitted observation of the phenomenon of incomplete bundle branch block in its dual expressions, namely, alterations in the action potential of the respective bundle branch and alterations in the ventricular complexes of the limb-lead electrocardiogram. As the effects of cocainization waned, the bundle action potential reflected intermediate stages between complete block of conduction and normal conduction. Likewise, the attendant ventricular complexes reflected intermediate stages between that form traditionally associated with complete block of the corresponding bundle and normal form. Characteristic shift in direction of the near-terminal QRS axis occurred with and without significant prolongation in QRS. Cocainization of a segment of the common bundle resulted in first, second, or third degree atrioventricular block, unattended by changes in form of associated ventricular complexes. As in bundle branch block, regression of common bundle block occurred also in stepwise fashion.