A Rapid Test for Adrenocortical Insufficiency
Authors: DONALD E. MAYNARD
Journal: Annals of Internal Medicine (1966)

Article1 March 1966A Rapid Test for Adrenocortical InsufficiencyDONALD E. MAYNARD, PH.D., ROBERT L. FOLK, M.D., THOMAS R. RILEY, M.D., RALPH G. WIELAND, M.D., F.A.C.P., GRANT GWINUP, M.D., GEORGE J. HAMWI, M.D., F.A.C.P.DONALD E. MAYNARD, PH.D.Search for more papers by this author, ROBERT L. FOLK, M.D.Search for more papers by this author, THOMAS R. RILEY, M.D.Search for more papers by this author, RALPH G. WIELAND, M.D., F.A.C.P.Search for more papers by this author, GRANT GWINUP, M.D.Search for more papers by this author, GEORGE J. HAMWI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-552 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of repeated infusions of adrenocorticotrophic hormone (ACTH) requiring 24-hour urine collections for 1 to 3 days has gained widespread acceptance in defining the functional integrity of the human adrenal cortex. However, the inconvenience of an infusion and the time required for specimen collection and measurement of urinary 17-hydroxycorticosteroids combine to make this procedure quite cumbersome.Other tests based on the response of plasma 17-hydroxycorticosteroids to infused ACTH (1, 2) still possess the discomfort and inconvenience of an infusion and rely on the laborious technique of measuring plasma 17, 21-dihydroxy-20-ketosteroids. Furthermore, this latter measurement (2) will include nonsteroidal substances...References1. EIK-NESSANDBERGNELSONTYLERSAMUELS KAADHFHLT: Changes in plasma levels of 17-hydroxycorticosteroids during the intravenous administration of ACTH. I. A test of adrenocortical capacity in the human. J. Clin. Invest. 33: 1502, 1954. CrossrefMedlineGoogle Scholar2. CHRISTYWALLACEJAILER NPEZJW: Comparative effects of prednisone and cortisone in suppressing the response of the adrenal cortex to exogenous adrenocorticotropin. J. Clin. Endocr. 16: 1059, 1956. CrossrefGoogle Scholar3. KRUGERWIELANDMAYNARDSCHACHNERHAMWI FARGDESHGJ: Comparison of fluorimetric corticoids and Porter-Silber 17-hydroxycorticoids during fasting. Metabolism 14: 199, 1965. CrossrefMedlineGoogle Scholar4. WIELANDSCHACHNERKRUGERMAYNARDHAMWI RGSHFADEGJ: A false elevation of plasma 17-hydroxycorticoids in diabetic ketosis. Diabetes 14: 744, 1965. CrossrefMedlineGoogle Scholar5. ARNERHEDNERKARLEFORSRERUP BPTC: One-hour subcutaneous ACTH test with determination of plasma corticosteroids. Acta Med. Scand. 173: 91, 1963. CrossrefGoogle Scholar6. WOODFRANKLANDJAMESLANDON JBAWVHJ: A rapid test of adrenocortical function. Lancet 1: 243, 1965. CrossrefMedlineGoogle Scholar7. MATTINGLY D: A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J. Clin. Path. 15: 374, 1962. CrossrefMedlineGoogle Scholar8. GANTTMAYNARDHAMWI CLDEGJ: Experience with a simple procedure for the determination of plasma and urine free 11-hydroxycorticoids. Metabolism 13: 1327, 1964. CrossrefMedlineGoogle Scholar9. SWEAT ML: Sulfuric acid-induced fluorescence of corticosteroids. Anal. Chem. 26: 773, 1954. CrossrefGoogle Scholar10. DEMOORSTEENORASKINHENDRIKX POMA: Fluorimetric determination of free plasma 11-hydroxycorticosteroids in man. Acta Endocr. (Kobenhavn) 33: 297, 1960. CrossrefMedlineGoogle Scholar11. STEWARTALBERT-RECHTOSMAN CPFLM: The simultaneous fluorimetric microdetermination of cortisol and corticosterone in plasma. Clin. Chim. Acta 6: 696, 1961. CrossrefMedlineGoogle Scholar12. WIELANDMAYNARDRILEYHAMWI RGDETRGJ: Detection of 21-deoxycortisol in blood from a patient with congenital adrenal hyperplasia. Metabolism 14: 1276, 1965. CrossrefMedlineGoogle Scholar13. COPE CL: Some adrenal facts and fancies. Proc. Roy. Soc. Med. 58: 55, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD E. MAYNARD, PH.D.; ROBERT L. FOLK, M.D.; THOMAS R. RILEY, M.D.; RALPH G. WIELAND, M.D., F.A.C.P.; GRANT GWINUP, M.D.; GEORGE J. HAMWI, M.D., F.A.C.P.Affiliations: Columbus, OhioFrom the Department of Medicine, Divsion of Endocrinology and Metabolism, and the Clinical Research Center, Ohio State University Hospitals, Columbus, Ohio.This study was supported in part by training grant TI AM 5118-09 and research grant FR-34 (Clinical Research Center), U. S. Public Health Service, Bethesda, Md.Dr. Folk is a Postdoctoral Research Fellow and Demonstrator in the Department of Medicine, Division of Endocrinology and Metabolism, University Hospitals, Ohio State University, Columbus, Ohio.Requests for reprints should be addressed to George J. Hamwi, M.D., Director, Division of Endocrinology and Metabolism, Department of Medicine, The Ohio State University Hospitals, 410 West 10th Ave., Columbus, Ohio 43210. 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Gabe synthetischer ACTH-Pr�parateSynacthen testSynacthen testTHE ONE-HOUR SYNTHETIC CORTICOTROPHIN TEST FOR RAPID ASSESSMENT OF ADRENAL FUNCTIONSurgery of the Adrenal GlandShock and the AdrenalSome recent advances in adrenal diagnosis. 1 March 1966Volume 64, Issue 3Page: 552-556KeywordsAdrenal cortexAdrenocorticotropic hormoneBlood plasmaCortisolEndocrinologyHospital medicineMedical servicesResearch grantsSpecimen preparation and treatmentUrine ePublished: 1 December 2008 Issue Published: 1 March 1966 PDF downloadLoading ...