tbuckley/cabot-search huggingface dataset:
Murmurs Arising from Ductus Arteriosus in Normal Newborn Swine
Authors: J. R. EVANS, R. D. ROWE, H. G. DOWNIE, H. C. ROWSELL
Journal: Circulation Research (1963)

The natural history of murmurs arising from the ductus arteriosus was investigated in normal newborn swine and compared with observations in other animals and infants at term. Ausenltation of 206 swine examined between birth and two weeks of age revealed a high incidence of continuous murmurs in the first six hours of life, crescendo systolic murmurs in 5% to 10% of animals during the first 24 hours and early systolic murmurs in a large proportion of the animals throughout the first week. Absence of a murmur was rare one to two hours after birth but, by 24 hours, less than 50% of the swine had murmurs of any type and after one week only one of 34 animals studied had a murmur. The continuous murmur was often preceded or followed by a crescendo systolic or early systolic murmur and it is proposed that all three murmurs arise from the ductus arteriosus under different conditions. Internal sound recordings with a phonocatheter in the thoracic aorta demonstrated a systolic murmur loudest at the orifice of the ductus arteriosus in all swine in the first six hours of life and in a decreasing proportion of animals thereafter. Evidence is presented to suggest that this murmur is closely linked to patency of the ductus arteriosus but is different in origin from the murmur normally heard on auscultation of the chest. In four animals under six hours of age the phonocatheter passed through the ductus into the pulmonary artery and a continuous murmur was recorded. In two older swine the phono-catheter traversed the ductus but in these cases the murmur in the main pulmonary artery was confined to systole. Since the occurrence of the different murmurs could not be satisfatorily explained on the basis of the systolic pressure gradient across the ductus nor on the basis of the anatomical size of the ductus at necropsy, it is postulated that the type of murmur generated is a reflection of the degree of narrowing of the lumen of the ductus produced by active constriction of its muscular wall during life.
Lung remodeling and pulmonary hypertension after myocardial infarction: pathogenic role of reduced caveolin expression
Authors: J JASMIN
Journal: Cardiovascular Research (2004)

Pulmonary hypertension (PH) and lung structural remodeling are frequent complications of congestive heart failure (CHF). Yet, the molecular mechanisms involved in CHF-induced PH and lung remodeling remain unknown. Caveolins (Cav-1, -2 and -3) are the principal structural proteins of the vesicular invaginations of the plasma membrane, termed caveolae. Mice with homozygous deletion of the caveolin-1 gene (Cav-1(-/-)) have been shown to develop dilated cardiomyopathy, PH and lung structural remodeling, characterized by hypercellularity and thickening of the alveolar septa. However, the physiological relevance of these observations for the pathogenesis of PH and lung remodeling remains to be determined.Here, we investigate the natural behavior of the endogenous caveolin proteins during the development of PH and lung structural remodeling, using a rat model of myocardial infarction (MI). MI was induced in male Wistar rats by ligating the left anterior coronary artery. Two weeks post-MI, rats were anesthetized and hemodynamic and morphometric measurements were obtained. Rats subjected to MI developed marked PH, lung structural remodeling and right ventricular hypertrophy (RVH). Both immunoblot analysis and immunohistochemistry dramatically show that Cav-1 and Cav-2 expression is downregulated to almost undetectable levels in the lungs of post-MI rats. Mechanistically, the reduced expression of caveolins was associated with the increased tyrosine-phosphorylation of the signal transducer and activator of transcription-3 (STAT3) and the upregulation of cyclin D1 and D3 expression. We also show that STAT3 is hyperphosphorylated, and cyclin D1 and D3 levels are dramatically upregulated, in lung tissue samples derived from Cav-1 (-/-)- and Cav-2 (-/-)-deficient mice.Thus, down-modulation of pulmonary Cav-1 and Cav-2 expression in rats subjected to MI may represent an initiating mechanism leading to the activation of the STAT3/Cyclins pathway and, ultimately, to the development of PH and lung structural remodeling.
KERATOSIS PALMO-PLANTARIS CONGENITA, WITH PERIO-DONTOSIS, ARACHNODACTYLY AND A PECULIAR DEFORMITY OF THE TERMINAL PHALANGES.
Authors: S. HAIM, J. MUNK
Journal: British Journal of Dermatology (1965)

Journal Article KERATOSIS PALMO‐PLANTARIS CONGENITA, WITH PERIO‐DONTOSIS, ARACHNODACTYLY AND A PECULIAR DEFORMITY OF THE TERMINAL PHALANGES. Get access S. HAIM, M.D., S. HAIM, M.D. Head of Dermatological Department, Rambam Government Hospital, Haifa, Israel Search for other works by this author on: Oxford Academic Google Scholar J. MUNK, M.D. J. MUNK, M.D. Head of X‐ray Department, Rambam Government Hospital, Haifa and Associate Clinical Professor in Radiology, the Faculty of Medicine, Hebrew University, Jerusalem Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 1, 1 January 1965, Pages 42–54, https://doi.org/10.1111/j.1365-2133.1965.tb14565.x Published: 01 January 1965
Protective and bronchodilator effects of prostaglandin E and salbutamol in aspirin-induced asthma.
Authors: A Szczeklik, L Mastalerz, E Nizankowska, A Cmiel
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We performed a double-blind, two-phase study on protective and bronchodilator effects of prostaglandins E2 and E1 (PGE2, PGE1) and salbutamol in patients with aspirin-induced asthma (AIA). In phase 1 we assessed the effects of pretreatment with PGE2, salbutamol, or the PGE1-analogue, misoprostol, on bronchoconstriction precipitated by inhalation of L-lysine aspirin in 11 patients with AIA. PGE2 and salbutamol were inhaled at equimolar concentrations of 0.25 mumol, 5 min before the aspirin challenge, while 400 micrograms misoprostol was administered orally 1 h before challenge. PGE2 attenuated the bronchoconstrictive reactions in 10 patients, salbutamol in eight, and misoprostol in seven. The mean provocative dose of aspirin causing a 20% fall in FEV1 (PD20) decreased after PGE2 (p = 0.04) and salbutamol (p = 0.06), but only marginally after misoprostol (p = 0.25). There was a positive correlation between magnitude of the protection offered by the three compounds in individual subjects. In phase 2, we examined bronchial response to inhaled PGE2, PGE1, salbutamol, and 2% ethanol in 12 AIA patients compared with 10 aspirin-tolerant patients with asthma. AIA subjects were characterized by less pronounced and shorter bronchodilator responses. There was no correlation between the protective and bronchodilator actions of the compounds used in individual patients. Thus, inhaled PGE2 and salbutamol protect against aspirin-induced attacks of asthma through mechanisms unrelated to their bronchodilator properties. Airways of aspirin-sensitive patients with asthma demonstrate distinct bronchial reactivity.
Clinical Gynecologic Endocrinology and Infertility
Authors: Irwin E. Thompson
Journal: JAMA (1989)

The new edition of this book follows the pattern of prior editions, which is to say that the book remains so concisely written, there is scarcely a superfluous sentence. The contents are divided into three major sections, which include the physiology of female reproduction, clinical endocrinology, and infertility. The section on physiology and biochemistry comprises three chapters that summarize recent developments in hormone biochemistry, neuroendocrinology, and the regulation of the menstrual cycle. Each of these chapters is very well written, highly informative, and completely up-to-date. For example, the new information on steroid receptor concepts is fully explained and integrated with the prior classic receptor model, while the section on the mechanism of action for trophic hormones is greatly expanded to include some of the most recent information, including the calcium messenger system. The chapter on neuroendocrinology contains recent information on the control of gonadotropin-releasing hormone pulses as well as a
Saturnine Gout — A Moonshine Malady
Authors: James R. Klinenberg
Journal: New England Journal of Medicine (1969)

Garrod, in 1931, first postulated that primary gout was "an inborn error of metabolism" and therefore all gouty patients were expected to share a common mechanism for their hyperuricemia. During the past decade, however, it has been demonstrated that although the primary defect in some of these patients is overproduction of uric acid, other patients with normal urate production have a renal defect resulting in diminished urate excretion, and a third group of gouty patients shares both these mechanisms.1 Classification of the myriad of conditions associated with hyperuricemia and secondary gout according to the basis for the hyperuricemia has also . . .
Readmissions After Implantation of Axial Flow Left Ventricular Assist Device
Authors: Tal Hasin, Yariv Marmor, Walter Kremers, Yan Topilsky, Cathy J. Severson, John A. Schirger, Barry A. Boilson, Alfredo L. Clavell, Richard J. Rodeheffer, Robert P. Frantz, Brooks S. Edwards, Naveen L. Pereira, John M. Stulak, Lyle Joyce, Richard Daly, Soon J. Park, Sudhir S. Kushwaha
Journal: Journal of the American College of Cardiology (2012)
Topophilia and the Quality of Life
Authors: Oladele A. Ogunseitan
Journal: Environmental Health Perspectives (2004)

With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Organization’s Quality of Life (WHOQOL-Bref) instrument. Confirmatory factor analyses revealed four domains of topophilia (ecodiversity, synesthetic tendency, cognitive challenge, and familiarity) and four domains of QOL (physical, psychological, social, and environmental). Synesthetic tendency was the strongest domain of topophilia, whereas the psychological aspect of QOL was the strongest. Structural equation modeling was used to explore the adequacy of a theoretical model linking topophilia and QOL. The model fit the data extremely well: χ2 = 5.02, p = 0.414; correlation = 0.12 (p = 0.047). All four domains of topophilia were significantly correlated with the level of restoration experienced by respondents at their current domicile [for cognitive challenge: r = 0.19; p &lt; 0.01; familiarity: r = 0.12; p &lt; 0.05; synesthetic tendency: r = 0.18; p &lt; 0.01; ecodiversity (the highest value): r = 0.28; p &lt; 0.01]. Within ecodiversity, preferences for water and flowers were associated with high overall QOL (r = 0.162 and 0.105, respectively; p &lt; 0.01 and 0.05, respectively). Within the familiarity domain, identifiability was associated with the environmental domain of QOL (r = 0.115; p &lt; 0.05), but not with overall QOL. These results provide a new methodologic framework for linking environmental quality and human health and for implementing evidence-based provision of restorative environments through targeted design of built environments to enhance human QOL.
Age and Health Perceptions of Psychogeriatric Patients
Authors: Vincenta Leigh, Sue Smolski
Journal: Psychotherapy and Psychosomatics (1987)

How the elderly perceive themselves has interested gerontologists for some time. Younger age perceptions have been associated with better psychological functioning or emotional adjustment. Most researchers and professionals agree that an important component of 'emotional adjustment' or 'mental health' is life satisfaction. Because of this consensus, numerous studies and papers have been written on life satisfaction in the elderly. In general, these studies have found significant correlations between life satisfaction and health, and despite the relative stability of life satisfaction, it can be affected by life events. While most studies have dealt with the 'healthy' elderly, there is little if any literature on elderly hospitalized psychiatric patients. This study explores age biases, health and age perceptions, as well as life satisfaction over the course of psychiatric hospitalization for geriatric patients. A questionnaire was developed to elicit age and health perceptions of psychogeriatric patients. The questionnaire was piloted with 17 geriatric patients admitted to the Geriatric Day Treatment Center. The questionnaire was administered to 24 patients admitted to the inpatient service of the Department of Geriatric Psychiatry during the first week of admission and on the week of discharge. The results of this study may help us with the educational needs of psychogeriatric patients regarding the normal aging process, as well as increase understanding of the effects of psychiatric illness on perceived age, health and life satisfaction in the geriatric population.
Ultrasonic Evaluation of Pararenal Masses
Authors: Edward H. Smith
Journal: JAMA (1975)

The ease of performing ultrasonic examination and its noninvasive nature make it especially useful in seriously ill patients. We present 12 patients with lesions that can be identified by ultrasound, along with a discussion of the differential diagnosis. Ultrasonically guided percutaneous aspiration biopsy can confirm the diagnosis in selected patients. (<i>JAMA</i>231:51-55, 1975)
Abstract SY22-01: Interrogating gene expression programs from preclinical analyses of genetically engineered mouse models
Authors: Cory Abate-Shen, Alvaro Aytes Meneses, Carolyn W. Kinkade, Antonina Mitrofanova, Celine Lefebvre, Chee Wai Chua, Mireia Castillo-Martin, Edward Gelmann, Michael M. Shen, Andrea Califano
Journal: Cancer Research (2011)

Abstract Our laboratories have been investigating novel mechanisms of cancer progression, as well as new therapeutic approaches for early intervention and treatment of advanced disease by integrating analyses of human clinical data with molecular and functional studies of genetically engineered mutant (GEM) mice. In our analyses of prostate cancer, we have generated GEM mice that recapitulate the entire spectrum of disease progression from preinvasive lesions, termed prostate intraepithelial neoplasia (PIN), to castration-resistant and metastatic disease, which are the lethal forms of the disease. These GEM models are based on perturbation of the Akt/mTOR and MAP kinase signaling pathways, which are often co-activated in human prostate cancer and which function synergistically to promote castration-resistant metastatic prostate cancer. We have found that combinatorial inhibition of these signaling pathways in GEM mice that display castration-resistant metastatic prostate cancer results in abrogation of primary tumors, improved survival and reduced metastasis. Using computational approaches for comparative analyses of large-scale gene expression profiling data for mouse and human prostate cancer, we have been assembling molecular networks, called interactomes, to elucidate conserved cancer pathways. We have been investigating the consequences of drugs perturbations on the transcriptional network with the ultimate goal of identifying new druggable targets. In summary, our comparative investigations of prostate cancer in humans and GEM mice have revealed promising new molecular targets and new therapuetic approaches for the treatment of human cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr SY22-01. doi:10.1158/1538-7445.AM2011-SY22-01
Book Review Marked in Your Flesh: Circumcision from Ancient Judea to Modern America By Leonard B. Glick. 370 pp. New York, Oxford University Press, 2005. $30. 0-19-517674-X A Surgical Temptation: The Demonization of the Foreskin and the Rise of Circumcision in Britain By Robert Darby. 374 pp. Chicago, University of Chicago Press, 2005. $35. 0-226-13645-0
Authors: David L. Gollaher
Journal: New England Journal of Medicine (2006)
Patients' and general practitioners' satisfaction with information given on discharge from hospital: audit of a new information card.
Authors: D. A. Sandler, C. Heaton, S. T. Garner, J. R. Mitchell
Journal: BMJ (1989)

<h3>Background</h3> In Burundi, malaria is considered a major public health concern and the leading cause of death. Malaria is responsible for up to 25% of all outpatient visits and up to 48% of all deaths in health facilities among children under five years old. Despite efforts made, timely access to health care is still limited, mainly due to geographic inaccessibility and lack of awareness about malaria complications. To increase timely access to malaria treatment, Burundi's Ministry of Health implemented Community Case Management of Malaria (CCMM) since 2015 in Kabonga. We sought to assess the impact of CCMM in improving malaria outcomes following two years of its initiation. <h3>Methods</h3> Selected community health workers (CHWs) were initially trained for simple malaria management among children under five years old using artemisinin-based combination therapy (ACT) and to perform rapid diagnostic tests for malaria (RDTs), and then equipped to provide service. This was a retrospective and prospective study using a mixed-methods approach between September-October 2017. Data before CCMM initiation (2013–2014) were collected from the Kabonga health centre, then compared to data from 2015–2016 corresponding to CCMM implementation. Data were from health records and stakeholders and were processed using SPSS. <h3>Results</h3> In total, 5922 children were treated for malaria between 2013–2014 and 5249 between 2015–2016, an 11,3% case decrease. CHWs managed in total 1751 children using ACTs between 2015–2016. Of them, 1297 (74%) had a consult within 24 hours of fever onset and the cure rate was approximately 90%. Mortality decreased with up to 75%. Ownership level was encouraging among beneficiary communities and was low among district and health center's staff. Some stock-outs were also reported. <h3>Conclusion</h3> Using trained CHWs increased access to timely and appropriate treatment in sampled communities which was associated with improved health outcomes among children under 5 years old. However, regular supply to CHWs and strong ownership is needed.
The John Phillips Memorial Award Lecture. Possible Injuries to the Cardiovascular System Due to Vitamin D Intake.
Authors: Helen B. Taussig
Journal: Annals of Internal Medicine (1966)

s1 May 1966The John Phillips Memorial Award Lecture. Possible Injuries to the Cardiovascular System Due to Vitamin D Intake.Helen B. Taussig, M.D., F.A.C.P.Helen B. Taussig, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1155_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe relation of vitamin D to the injury of the cardiovascular system is far from clear but evidence is steadily increasing to show that in all probability, at least in certain instances, excessive vitamin D intake may cause extensive injury to the cardiovascular system. This evidence is derived from our knowledge of idiopathic hypercalcemia and those changes seen in the type of supravalvular aortic stenosis that is associated with mental retardation of a peculiar facies.The clinical syndrome of supravalvular aortic stenosis, associated with peripheral pulmonary stenosis, mental retardation, peculiar facies, and an abnormal denture, is now well established. In... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1155-1156KeywordsHypercalcemiaIntellectual disabilityStenosisVitamin D Issue Published: 1 May 1966 PDF downloadLoading ...
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
Authors: Luca Gattinoni, Xiao-Song Zhong, Douglas C Palmer, Yun Ji, Christian S Hinrichs, Zhiya Yu, Claudia Wrzesinski, Andrea Boni, Lydie Cassard, Lindsay M Garvin, Chrystal M Paulos, Pawel Muranski, Nicholas P Restifo
Journal: Nature Medicine (2009)
Low Frequency of Colorectal Dysplasia in Patients with Long-Standing Inflammatory Bowel Disease Colitis: Detection by Fluorescence Endoscopy
Authors: T. Ochsenkühn, C. Tillack, H. Stepp, J. Diebold, S. Ott, R. Baumgartner, S. Brand, B. Göke, M. Sackmann
Journal: Endoscopy (2006)

Background and Study Aim: Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colonic dysplasias. Dysplastic changes in flat mucosa are likely to be missed by conventional colonoscopy. Endoscopic fluorescence imaging, using 5-aminolevulinic acid (5-ALA) as photosensitizer, has evolved as a new technique to differentiate between normal colonic mucosa and dysplasia. We combined this technique with random biopsies to prospectively evaluate the occurrence of dysplasias in patients with long-standing IBD. Patients and Methods: 52 colonoscopies were performed in 42 consecutive patients (n = 28 with ulcerative colitis, n = 11 with Crohn’s colitis, n = 3 with indeterminate colitis; mean age 43 years, range 21 - 78) with long-standing IBD colitis (median disease duration 14 years, range 3 - 40). All patients were in clinical remission. Patients were examined using both conventional white light and by fluorescence colonoscopy using oral 5-ALA. Four biopsies were taken every 10 cm from mucosa of normal appearance. In addition, macroscopically suspicious and fluorescence-positive areas were biopsied. Results: A total of 688 biopsies of red-fluorescent (n = 20) and nonfluorescent (n = 662) areas of mucosa were taken. Dysplasia was detected histopathologically in only two of the biopsies. These biopsies were taken from two polypoid lesions which were fluorescence-negative. Conclusions: The rate of colonic dysplasia in patients with long-standing IBD colitis may be lower than previously reported.
Epidermal Growth Factor Receptor P753S Mutation in Cutaneous Squamous Cell Carcinoma Responsive to Cetuximab-Based Therapy
Authors: Prasanth Ganesan, Siraj M. Ali, Kai Wang, George R. Blumenschein, Bita Esmaeli, Robert A. Wolff, Vincent A. Miller, Phillip J. Stephens, Jeffery S. Ross, Gary A. Palmer, Filip Janku
Journal: Journal of Clinical Oncology (2014)
RhoH is important for positive thymocyte selection and T-cell receptor signaling
Authors: Tatjana Dorn, Ursula Kuhn, Gerd Bungartz, Sebastian Stiller, Martina Bauer, Joachim Ellwart, Thorsten Peters, Karin Scharffetter-Kochanek, Monika Semmrich, Melanie Laschinger, Bernhard Holzmann, Wolfgang E. F. Klinkert, Per Thor Straten, Tania Køllgaard, Michael Sixt, Cord Brakebusch
Journal: Blood (2006)