Benign Recurrent Intrahepatic Cholestasis in Two Brothers
Authors: LUIZ CAETANO DA SILVA
Journal: Annals of Internal Medicine (1966)

Case Studies1 August 1966Benign Recurrent Intrahepatic Cholestasis in Two BrothersA Clinical, Light, and Electron Microscopy StudyLUIZ CAETANO DA SILVA, M.D., THALES DE BRITO, M.D.LUIZ CAETANO DA SILVA, M.D.Search for more papers by this author, THALES DE BRITO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-330 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBenign recurrent intrahepatic cholestasis is a recently described disorder (1) characterized by attacks of jaundice with obstructive features recurring over a number of years. Though the etiology is obscure, the coincidence in two boys, possibly related (2), and in two brothers (3) suggests that this may be a constitutional form of jaundice. In some cases (1, 4-6), inquest or examination of the families were negative, and according to Williams and associates (6), the evidence for an acquired or genetic defect is far from conclusive.Summerskill (7) concluded in 1965 that eight cases had been published so far. But adding 2...References1. SUMMERSKILLWALSHE WHJM: Benign recurrent intrahepatic "obstructive" jaundice. Lancet 2: 686, 1959. CrossrefMedlineGoogle Scholar2. TYGSTRUP N: Intermittent possibly familial intrahepatic cholestatic jaundice. Lancet 1: 1171, 1960. CrossrefMedlineGoogle Scholar3. KÜHN HA: Intrahepatic cholestasis in two brothers. German Med. Monthly 8: 185, 1963. Google Scholar4. DE GROOTEGOUBEAUVANDENBROUCKE JPJ: Ictère cholostatique récidivant. Acta Gastroent. Belg. 23: 747, 1960. MedlineGoogle Scholar5. SCHAPIROISSELBACHER RHKJ: Benign recurrent intrahepatic cholestasis. New Eng. J. Med. 268: 708, 1963. CrossrefMedlineGoogle Scholar6. WILLIAMSCARTTERSHERLOCKSCHEUERHILL RMASPJKR: Idiopathic recurrent cholestasis: a study of the functional and pathological lesion in four cases. Quart. J. Med. 33: 387, 1964. MedlineGoogle Scholar7. SUMMERSKILL WH: The syndrome of benign recurrent cholestasis. Amer. J. Med. 38: 298, 1965. CrossrefMedlineGoogle Scholar8. SPIEGELSCHUBERTPERRINSCHIFF ELWEL: Some observations on a case of recurrent intrahepatic cholestasis (abstract). Gastroenterology 48: 502, 1965. Google Scholar9. MALLOYEVELYN HTKA: The determination of bilirubin with the photoelectric colorimeter. J. Biol. Chem. 119: 481, 1937. CrossrefGoogle Scholar10. DUCCIWATSON HCJ: The quantitative determination of the prompt-reacting and the chloroform-soluble types. J. Lab. Clin. Med. 30: 293, 1945. Google Scholar11. FRANKELREITMAN SS: Gradwohl's Clinical Laboratory Methods and Diagnosis. C. V. Mosby Co., St. Louis, 1963. Google Scholar12. GRASSMANNHANNINGKNEDEL WKM: Ueber ein Verfahren zur elektrophoretischen Bestimmung der Serumprotein auf Filtrierpapier. Klin. Wschr. 11: 333, 1951. CrossrefGoogle Scholar13. DA SILVADE GODOYKURBANNEVESPONTES LCASTDPJF: Estudo crítico dos testes de floculação: mecanismos e valor prático. Rev. As. Med. Brasil 4: 303, 1958. MedlineGoogle Scholar14. WATSON ML: Staining of tissue sections for electron microscopy with heavy metals. J. Biophys. Biochem. Cytol. 4: 475, 1958. CrossrefMedlineGoogle Scholar15. REYHOLDS ES: The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J. Cell Biol. 17: 208, 1963. CrossrefMedlineGoogle Scholar16. SCHEUERWILLIAMSHILLSHERLOCK PJRKRS: Idiopatic recurrent hyperbilirubinaemia. T. Gastroent. 7b: 173, 1964. Google Scholar17. DICKSONFLETSCHERSUMMERSKILL ERJWH: Ultrastructural changes of the liver in benign recurrent cholestasis. Mayo Clin. Proc. 40: 288, 1965. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: São Paulo,From Hospital das Clínicas and Instituto de Medicina Tropical, the University of São Paulo, S. Paulo, Brazil.This work was aided by grants from Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia and Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil.Requests for reprints should be addressed to Luiz Caetano da Silva, M.D., Instituto de Medicina Tropical de S. Paulo, Caixa Postal 2921, S. Paulo, Brazil. 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