Subgroup Results in the DASH-Sodium Trial
Authors: William M. Vollmer
Journal: Annals of Internal Medicine (2002)

Letters5 November 2002Subgroup Results in the DASH-Sodium TrialWilliam M. Vollmer, PhD, Frank M. Sacks, MD, and Lawrence J. Appel, MDWilliam M. Vollmer, PhDCenter for Health Research; Kaiser Permanente NW; Portland, OR 97227Brigham and Women's Hospital; Boston, MA 02115Johns Hopkins University; Baltimore, MD 21205Search for more papers by this author, Frank M. Sacks, MDCenter for Health Research; Kaiser Permanente NW; Portland, OR 97227Brigham and Women's Hospital; Boston, MA 02115Johns Hopkins University; Baltimore, MD 21205Search for more papers by this author, and Lawrence J. Appel, MDCenter for Health Research; Kaiser Permanente NW; Portland, OR 97227Brigham and Women's Hospital; Boston, MA 02115Johns Hopkins University; Baltimore, MD 21205Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-9-200211050-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Jürgens and Graudal base their argument on the observation that, although reduced sodium significantly lowered systolic blood pressure in nonhypertensive white persons, it did not significantly lower diastolic blood pressure in this subgroup. First, the effect on diastolic blood pressure in this group was indeed significant (−1.4 mm Hg [95% CI, −2.8 mm Hg to −0.1 mm Hg] in those following the control diet). Second, we would like to clarify that our subgroup results for this trial have consistently reported data for African-American persons versus non–African-American persons; the latter group is composed predominantly of white persons. Finally, ...References1. Graudal NA, Galløe AM, Garred P. Effects of sodium restriction on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglyceride: a meta-analysis. JAMA. 1998;279:1383-91. [PMID: 9582047] CrossrefMedlineGoogle Scholar2. Cutler JA, Follmann D, Allender PS. Randomized trials of sodium reduction: an overview. Am J Clin Nutr. 1997;65:643S-651S. [PMID: 9022560] CrossrefMedlineGoogle Scholar3. . Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure. The Trials of Hypertension Prevention, phase II. The Trials of Hypertension Prevention Collaborative Research Group. Arch Intern Med. 1997;157:657-67. [PMID: 9080920] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: William M. Vollmer, PhD; Frank M. Sacks, MD; Lawrence J. Appel, MDAffiliations: Center for Health Research; Kaiser Permanente NW; Portland, OR 97227Brigham and Women's Hospital; Boston, MA 02115Johns Hopkins University; Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Diet and Sodium Intake on Blood Pressure: Subgroup Analysis of the DASH-Sodium Trial William M. Vollmer , Frank M. Sacks , Jamy Ard , Lawrence J. Appel , George A. Bray , Denise G. Simons-Morton , Paul R. Conlin , Laura P. Svetkey , Thomas P. Erlinger , Thomas J. Moore , and Njeri Karanja , for the DASH-Sodium Trial Collaborative Research GroupSubgroup Results in the DASH-Sodium Trial Gesche Jürgens and Niels Graudal Metrics 5 November 2002Volume 137, Issue 9Page: 772-773KeywordsBloodBlood pressureDietFoodHypertensionResearch designSodiumSystolic pressure ePublished: 5 November 2002 Issue Published: 5 November 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...