tbuckley/cabot-search huggingface dataset:
STUDIES OF THE LYMPHATIC TISSUE
Authors: Wilhelm Ehrich
Journal: The Journal of Experimental Medicine (1929)

1. On subcutaneous infection of rabbits with staphylococci of low virulence there appears at the place of injection first a hemorrhagicpurulent inflammation and later a localized purulence. In the regional lymph nodes there is lymphatic hyperplasia, and in the blood a lymphocytosis. 2. In the regional lymph nodes there is first a regressive change of Flemming's secondary nodules and of transition forms. Then follows lymphatic hyperplasia, starting apparently from solid secondary nodules and progressing by way of pseudo-secondary nodules to a diffuse lymphoid hyperplasia. The increase of lymphocytes in the blood parallels this development. 3. Only after the highest point of the lymphocytosis has been reached or passed do we find the first Flemming's secondary nodules, which thereafter increase in number and size while the number of lymphocytes in the blood falls, and reach their maximum development when the number of lymphocytes in the blood is again normal. Therefore, the original conception of Flemming that the site of formation of the lymphocytes of the blood is in Flemming's secondary nodules, cannot be accepted. 4. The lymphocytes of the blood originate in the pseudo-secondary nodules as in embryonic life. The mother cells of the lymphocytes would appear to be Marchand's proliferating endothelial (reticular) cells.
Respiratory Care: A Guide to Clinical Practice
Authors: Thomas L. Petty
Journal: JAMA (1978)

The field of respiratory care has advanced remarkably in the past 25 years. Many of the 46 contributors to this text have played an important role in this program. The editors have organized a complete review, encompassing historical aspects, techniques, devices, and applications. Thirty-eight chapters are organized into three sections: the education of respiratory care workers and the development of physical facilities, what we know regarding the rational and scientific basis for respiratory care, and applications of care techniques in major clinical situations. The text is physiologically oriented, is forthright in areas of controversy, and properly stresses the recently published standards for respiratory care and the impact of the Sugarloaf Conference held in 1974. Some chapters are overly brief and some duplication is present, but the sequence of chapter organization is excellent. For example, a discussion of tube techniques and procedures is followed by chapters dealing with mechanical ventilation, including
Treatment of Puerperal Eclampsia by a Combined Method
Authors: J. Lithgow
Journal: BMJ (1904)

CAsE IV.Mrs. D., aged 35, a most nervous and hlsterical patient, had been in labour some hours before I saw her, the membranes having ruptured early.The os was dilated to the size of a shilling and the vertex was pressing on the lower uterine segment.The patient complained of great pain and the uterine contractions were of little or no use as wregards further dilatation.I administered chloroform to a slight extent and waited for three 'hours.The condition did not improve, and as the patient was worn .outand in an exceedingly nervous state I pushed the chloroform, gradually dilated the os and, applying forceps, delivered her with -difficulty of a large stillborn child.The patient made a splendid 'recovery.
Long-term Cigarette Smoking Impairs Endothelium-Dependent Coronary Arterial Vasodilator Function
Authors: Andreas M. Zeiher, Volker Schächinger, Jan Minners
Journal: Circulation (1995)

Background Smoking is a primary risk factor for coronary and peripheral vascular disease. Because the endothelium is a principal target for the effects of risk factors early in the pathogenesis of atherosclerosis, we investigated whether long-term smoking is associated with impaired endothelial vasodilator function of epicardial conductance vessels regardless of the presence or absence of atherosclerotic lesions. Methods and Results Using quantitative coronary angiography, we measured epicardial artery diameter at baseline, after maximal increases in coronary blood flow that caused flow-mediated dilation (which is strictly endothelium dependent), and after intracoronary injection of nitroglycerin (an endothelium-independent dilator) in 96 patients. Endothelium-dependent, flow-mediated dilation was significantly ( P &lt;.0001) blunted in smokers (n=46) compared with nonsmokers (n=50). The ratio of flow-dependent dilation to nitroglycerin-induced dilation was significantly ( P &lt;.001) lower in smokers (0.34±0.32) compared with nonsmokers (0.59±0.23), indicating that the blunted dilator response to increased blood flow was out of proportion to the mildly impaired dilator response to nitroglycerin in smokers. In the presence of angiographically visible atherosclerosis, flow-dependent dilation was essentially absent (3.0±6.5%) in smokers. Multivariate analysis revealed that luminal irregularities by angiography ( P &lt;.0001) and smoking ( P &lt;.001) were the only variables to be independently associated with a reduced flow-dependent dilator response of epicardial arteries. Intracoronary ultrasound demonstrated that flow-dependent dilation progressively decreased with increasing atherosclerotic plaque load ( r =−.82, P &lt;.0001; n=24). However, over the entire range of wall thickening, segments from smokers exhibited a significantly ( P &lt;.01) impaired flow-dependent dilator response compared with those of nonsmokers. Conclusions Long-term cigarette smoking is associated with impaired endothelium-dependent coronary vasodilation regardless of the presence or absence of coronary atherosclerotic lesions.
Identification of the Wilson's disease gene: Clues for disease pathogenesis and the potential for molecular diagnosis
Authors: Michael L. Schilsky
Journal: Hepatology (1994)

Wilson disease (WD) is an autosomal recessive disorder of copper transport which maps to chromosome 13q14.3. In pursuit of the WD gene, we developed yeast artificial chromosome and cosmid contigs, and microsatellite markers which span the WD gene region. Linkage disequilibrium and haplotype analysis of 115 WD families confined the disease locus to a single marker interval. A candidate cDNA clone was mapped to this interval which, as shown in the accompanying paper, is very likely the WD gene. Our haplotype and mutation analyses predict that approximately half of all WD mutations will be rare in the American and Russian populations. Wilson disease (WD) is an autosomal recessive disorder characterized by the toxic accumulation of copper in a number of organs, particularly the liver and brain. As shown in the accompanying paper, linkage disequilibrium & haplotype analysis confirmed the disease locus to a single marker interval at 13q14.3. Here we describe a partial cDNA clone (pWD) which maps to this region and shows a particular 76% amino acid homology to the Menkes disease gene, Mc1. The predicted functional properties of the pWD gene together with its strong homology to Mc1, genetic mapping data and identification of four independent disease-specific mutations, provide convincing evidence that pWD is the Wilson disease gene. Wilson disease (WD) is an autosomal recessive disorder of copper transport, resulting in copper accumulation and toxicity to the liver and brain. The gene (WD) has been mapped to chromosome 13 q14.3. On yeast artificial chromosomes from this region we have identified a sequence, similar to that coding for the proposed copper binding regions of the putative ATPase gene (MNK) defective in Menkes disease. We show that this sequence forms part of a P-type ATPase gene (referred to here as Wc1) that is very similar to MNK, with six putative metal binding regions similar to those found in prokaryotic heavy metal transporters. The gene, expressed in liver and kidney, lies within a 300 kb region likely to include the WD locus. Two WD patients were found to be homozygous for a seven base deletion within the coding region of WC1. WC1 is proposed as the gene for WD. The putative copper and ATP-binding domains of the human Menkes disease gene were used as probes to screen a human liver cDNA library at reduced stringency. Sixty-five clones which remained positive after tertiary screening were subcloned and sequenced. One of these cDNA clones contains an open reading frame with 65% amino acid homology to the Menkes protein. Southern blot analysis localizes this cDNA to the region of the Wilson disease locus on chromosome 13. This cDNA detects a 7.5 kB transcipt which is present in human liver and cell lines devoid of the Menkes transcript and which is absent in liver from a patient with Wilson disease. These data suggest that this cDNA is a candidate gene for Wilson disease and that the protein encoded at this locus is a member of the P-type ATPase family.
Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells
Authors: Yi Jia, Huifeng Yu, Steve M. Fernandes, Yadong Wei, Anabel Gonzalez-Gil, Mary G. Motari, Katarina Vajn, Whitney W. Stevens, Anju T. Peters, Bruce S. Bochner, Robert C. Kern, Robert P. Schleimer, Ronald L. Schnaar
Journal: Journal of Allergy and Clinical Immunology (2015)
Doing our duty on episodic hypertension
Authors: D. Spence
Journal: BMJ (2010)

I don’t know why I listen, because it instantly raises my blood pressure. Radio 4’s Today programme clicks on at 6.30 am. General practitioners are the foot soldiers of medicine, with our commanders in distant war rooms planning the next big push on disease. We generally do their bidding, fearing that we would be shot by the General Medical Council as mutineers if we didn’t. So when a medical general announces new research on high blood pressure I hold my breath. This time, the unqualified sound bite is that patients with isolated readings of …
High prevalence of and potential mechanisms for chronic kidney disease in patients with acute intermittent porphyria
Authors: Nicolas Pallet, Iadh Mami, Caroline Schmitt, Zoubida Karim, Arnaud François, Marion Rabant, Dominique Nochy, Laurent Gouya, Jean-Charles Deybach, Yichum Xu-Dubois, Eric Thervet, Hervé Puy, Alexandre Karras
Journal: Kidney International (2015)
Japanese institute investigates claim that acid solution can transform mature mice cells into stem cells
Authors: N. Hawkes
Journal: BMJ (2014)

A claim that was described as “revolutionary” and a “game changer” in stem cell biology has been called into question as the Japanese institute from which it originated opened an investigation into its credibility.

In January a team from the RIKEN Center for Developmental Biology in Kobe reported that it had reprogrammed mature mice cells into an embryonic state by brief exposure to an acid solution. The discovery came from Haruko Obokata, a biologist working at the centre, and coworkers including the US anaesthetist Charles Vacanti of Harvard Medical School. Two papers describing the achievement were published in Nature 1 …
Woody hands in a patient with pancreatic carcinoma: a variant of cancer-associated fasciitis-panniculitis syndrome
Authors: N.H. COX, B. RAMSAY, C. DOBSON, J.S. COMAISH
Journal: British Journal of Dermatology (1996)

Journal Article Woody hands in a patient with pancreatic carcinoma: a variant of cancer‐associated fasciitis‐panniculitis syndrome Get access N.H. COX, N.H. COX Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Dr. N.H.Cox, Department of Dermatology, Cumberland Infirmary, Carlisle, CA2 7HY, U.K. Search for other works by this author on: Oxford Academic Google Scholar B. RAMSAY, B. RAMSAY Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar C. DOBSON, C. DOBSON Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar J.S. COMAISH J.S. COMAISH Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 6, 1 December 1996, Pages 995–998, https://doi.org/10.1046/j.1365-2133.1996.d01-1110.x Published: 01 December 1996 Article history Accepted: 21 May 1996 Published: 01 December 1996
The Treatment of Croup with Glucocorticoids
Authors: David M. Jaffe
Journal: New England Journal of Medicine (1998)

In this issue of the Journal, Johnson et al. report that in children with moderately severe croup, a single dose of intramuscular dexamethasone (0.6 mg per kilogram of body weight) or nebulized budesonide (4 mg) resulted in significantly fewer hospitalizations than did the administration of placebo and that dexamethasone was associated with greater clinical improvement than budesonide five hours after treatment.1 Klassen et al.2 recently demonstrated that the clinical effect of a single dose of oral dexamethasone (0.6 mg per kilogram) was similar to that of nebulized budesonide (2 mg) alone or in combination with dexamethasone. These results add to . . .
Guillain-Barre syndrome after measles.
Authors: G Lidin-Janson, O Strannegard
Journal: BMJ (1972)

This procedure would have two advan- tages.The first is that it would overcome many of the administrative difficulties, both on the ward and in the laboratory, which arise from the necessity of sending a plasma sample and request card to the laboratory on one day and the 24-hour urine sample with a second request card on the following day.If the plasma is taken when the collec- tion is completed, both specimens can be sent with a single request card.The second, perhaps less important, advantage is that with this procedure the change in creatinine clearance will be greater than with the conventional method should the plasma creatinine be rising or falling during the period of the urine collection.For example, if renal function were deteriorating and plasma creatinine rising the creatinine clear- ance would be lower if the plasma is taken at the end of the urine collection than if it is taken in the middle.There is no doubt that clinical biochemistry laboratories would welcome this change in procedure, and it appears to have no clinical disadvantages.-Weare, etc.,
An International Study of the Relation between Somatic Symptoms and Depression
Authors: Gregory E. Simon, Michael VonKorff, Marco Piccinelli, Claudio Fullerton, Johan Ormel
Journal: New England Journal of Medicine (1999)

Patients with depression, particularly those seen by primary care physicians, may report somatic symptoms, such as headache, constipation, weakness, or back pain. Some previous studies have suggested that patients in non-Western countries are more likely to report somatic symptoms than are patients in Western countries.
Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34/IGKV1 receptor
Authors: Magali Colombat, Hervé Mal, Christiane Copie-Bergman, Jacques Diebold, Diane Damotte, Patrice Callard, Michel Fournier, Jean-Pierre Farcet, Marc Stern, Marie-Hélène Delfau-Larue
Journal: Blood (2008)
Chaucer and Medicine
Authors: Ynez Violé O'Neill
Journal: JAMA (1969)

On Tuesday evening, April 16, 1387, twenty-nine pilgrims gathered at the Tabard, an inn on the south bank of the Thames. Thus began a journey that immortalized the man who had envisaged it, as well as the society that produced him.<i>The Canterbury Tales</i>are perhaps the finest expression of Chaucer's genius, and his writings are a perpetual fountain of data concerning life and learning in medieval England. Exceptionally endowed with abundant good sense and originality, Chaucer, like most educated men of his time, was also well grounded in the medical lore of the 14th century, as even a cursory reading of any of his longer works will demonstrate. Considering the wealth of this material, and the fact that elaborate scholarly scaffoldings have been erected on even seemingly insignificant details in his poems, it is surprising to find that relatively little attention has yet been directed toward numerous allusions to
The Contribution of Changes in the Prevalence of Prone Sleeping Position to the Decline in Sudden Infant Death Syndrome in Tasmania
Authors: Terence Dwyer
Journal: JAMA (1995)

To determine the independent contribution of changes in infant sleep position to the recent decline in sudden infant death syndrome (SIDS) rate in Tasmania.(1) A comparison of the whole population incidence of SIDS before and after an intervention to reduce the prevalence of prone sleeping position. (2) A within-cohort analysis of the contribution of sleep position and other exposures to the decline in SIDS after the intervention.Tasmania, Australia.(1) All SIDS cases from 1975 through 1992. (2) A sample of one in five infants born in Tasmania who at perinatal assessment were scored to be at higher risk for SIDS since January 1988. Of 5534 infants included in the study, 39 later died of SIDS.Multiple public health activities to reduce the prevalence of the prone infant sleeping position in Tasmania and verbal information on the association between prone position and SIDS to cohort participants from May 1, 1991.Sudden infant death syndrome incidence.The Tasmanian SIDS rate decreased (P < .01) from 3.8 (95% confidence interval [CI], 3.5 to 4.2) deaths per 1000 live births from 1975 through 1990 to a rate of 1.5 (95% CI, 0.9 to 2.2) deaths per 1000 live births in 1991 through 1992. The SIDS mortality rate in the cohort by period of birth was 7.6 (95% CI, 4.9 to 10.3) deaths per 1000 live births for those born from May 1, 1988, through April 30, 1991, and 4.1 (95% CI, 1.3 to 7.0) deaths per 1000 infants for those born from May 1, 1991, through October 31, 1992. The prevalence of usual prone sleeping position at 1 month of age was 29.9% and 4.3% in these two cohorts, respectively (adjusted odds ratio, 0.11; 95% CI, 0.08 to 0.13). Logistic regression demonstrated that 70% of the SIDS rate reduction in the cohort could be accounted for by the decreased prevalence of the prone sleeping position. Other factors examined individually contributed to less than 10% of the SIDS rate reduction.The major contributing factor to the recent SIDS rate decline in Tasmania has been the reduction in the proportion of infants usually sleeping prone.
Prosthetic Valve Endocarditis Caused by Staphylococcus epidermidis
Authors: Bruce Chamovitz, Richard E. Bryant, David N. Gilbert, Alan I. Hartstein
Journal: JAMA (1985)

Development of rifampin-resistant Staphylococcus epidermidis was documented in three patients receiving vancomycin and rifampin therapy for prosthetic valve endocarditis. The minimum inhibitory concentrations and minimum bactericidal concentrations of rifampin for the original three isolates were 0.4 micrograms/mL or less. Organisms cultured during relapse or prosthetic valve replacement had minimum inhibitory concentrations of rifampin that were 12.5, 50, and greater than 100 micrograms/mL, respectively. Surgical intervention was necessary in all patients. One died, and one required a second prosthetic valve placement. The patients were treated with vancomycin plus aminoglycoside following identification of rifampin resistance. These observations suggest that vancomycin and rifampin may not be adequate therapy for prosthetic valve endocarditis caused by S epidermidis.
Intraosseous phlebography and fat embolism.
Authors: A E Young, M L Thomas, N L Browse
Journal: BMJ (1976)

Acute myelomonocytic leukaemia and multiple myeloma after sulphinpyrazone and colchicine treatment of gout Mild haematological toxicity was noted during a five-month study in which 22 patients with gout received the uricosuric drug sulphinpyrazone (table 1).Eight developed a moderate granulocytopenia compared with only four out of 22 age-and sex-matched controls with rheumatoid arthritis.This difference was not, however, stat- istically significant (P=0 3).In a long-term study fatal blood dycrasias occurred in three out of 25 patients with gout who took sulphinpyrazone for 2-8 to 14 years and colchicine intermittently for shorter intervals. Case reportsCase 1-A 69-year-old house painter with a rnine-year history of gout received sulphinpyrazone regularly and-colchicine intermittently during the four years before his death from acute myelomonocytic leukaemia in 1962.No exposure to solvents was recorded.The terminal illness was characterised by considerable anaemia, thrombocytopenia, a preponderence of inmature lymphocytes with monocytoid features in the peripheral blood, and hepatic and splenic leukaemic infiltrates at necropsy.
Retention of urine in occult anorectal herpes.
Authors: W Atia, C Sonnex
Journal: BMJ (1986)

Retention of urine in occult anorectal herpesUrinary retention in patients with symptomatic anogenital herpes simplex infection is well documented.We report two cases ofmicturition difficulties in patients with occult anorectal infection. Case reportsCase I-A 23 year old man was transferred to the Whittington Hospital from HM prison with acute urinary retention which necessitated catheterisation.He gave a five day history of dysuria without urethral discharge and denied anal discomfort or discharge.The anus and perianal area appeared normal but proctoscopy showed a severely inflamed rectal mucosa.Both rectal and urethral smears contained multiple polymorphs but no organisms on Gram staining and were negative on culture for Neisseria gonorrhoeae and Chianydia trachomatis.
THE CUTANEOUS REACTIONS PRODUCED BY o-CHLOROBENZYL-IDENEMALONONITRILE AND ω-CHLOROACETOPHENONE WHEN APPLIED DIRECTLY TO THE SKIN OF HUMAN SUBJECTS
Authors: P. HOLLAND, R. G. WHITE
Journal: British Journal of Dermatology (1972)

Journal Article THE CUTANEOUS REACTIONS PRODUCED BY o‐CHLOROBENZYL‐IDENEMALONONITRILE AND ω‐CHLOROACETOPHENONE WHEN APPLIED DIRECTLY TO THE SKIN OF HUMAN SUBJECTS Get access P. HOLLAND, P. HOLLAND Chemical Defence Establishment, Porton Down, Salisbury, Wilts Search for other works by this author on: Oxford Academic Google Scholar R. G. WHITE R. G. WHITE Chemical Defence Establishment, Porton Down, Salisbury, Wilts Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 2, 1 February 1972, Pages 150–154, https://doi.org/10.1111/j.1365-2133.1972.tb16078.x Published: 01 February 1972 Article history Accepted: 25 August 1971 Published: 01 February 1972
The World Medical Tennis Championships--Bournemouth 1982
Authors: O. D. Beresford
Journal: British Journal of Sports Medicine (1982)

The World Medical Tennis Society is open to doctors who, according to its constitution, as revised at Garmisch, Germany in July 1981, wish to promote tennis participation among physicians.Its further aims include, promotion of international friendship, encouragement of physical fitness, particularly in relation to aging and illness and the exchange of information and experience.This it does by promoting tennis tournament on an international basis in which time is set aside for the reading of appropriate papers.Such a tournament was held for the first time in Great Britain at Bournemouth from 19th to 27th June, 1982 with the British Medical Tennis Association acting as hosts.
KOREA: CURRENT PSYCHIATRIC PROCEDURE AND COMMUNICATION IN THE COMBAT THEATER
Authors: ROBERT M. EDWARDS, DONALD B. PETERSON
Journal: American Journal of Psychiatry (1954)

The case of a 25-year-old infantryman who became a neuropsychiatric casualty in the Korean War is presented, to permit illustration of the application of current military psychiatric concepts, method of communication, and discussion of their rationale.