tbuckley/cabot-search huggingface dataset:
Pupillary Abnormalities: Light and Sight
Authors: DAVID S. BARDENSTEIN
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 April 1987Pupillary Abnormalities: Light and SightDAVID S. BARDENSTEIN, M.D., NORMAN N. K. KATZ, M.D., DAVID S. FRIENDLY, M.D., MARSHALL M. PARKS, M.D.DAVID S. BARDENSTEIN, M.D.Search for more papers by this author, NORMAN N. K. KATZ, M.D.Search for more papers by this author, DAVID S. FRIENDLY, M.D.Search for more papers by this author, MARSHALL M. PARKS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-4-643_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A survey of major pediatrics and neonatology textbooks shows few recommendations concerning the need for immediate referral of infants, toddlers, and children with abnormal pupillary reflexes (leukocoria). The differential diagnosis of childhood leukocoria includes various conditions of which the most important are retinoblastoma, cataract, persistent hyperplastic primary vitreous (PHPV), retinal detachment, infections, and inflammations.The prognosis for life in patients with retinoblastoma is directly related to the size and degree of extension of the tumor and thus to the promptness with which the disease is recognized. The great improvement in survival of patients with retinoblastoma has been...References1. BELLAR R, HOYT C, MARG E, and ODOM J. Good visual function after neonatal surgery for congenital monocular cataracts. Am J Ophthalmol. 1981;91:559-65. CrossrefMedlineGoogle Scholar2. PARKS M. Visual results in aphakic children. Am J Ophthalmol. 1982;94:441-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID S. BARDENSTEIN, M.D.; NORMAN N. K. KATZ, M.D.; DAVID S. FRIENDLY, M.D.; MARSHALL M. PARKS, M.D.Affiliations: Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1987Volume 106, Issue 4Page: 643-643KeywordsChildrenInfantsInflammationLife expectancyPediatric infectionsPediatricsReflexesRetinal detachment ePublished: 1 December 2008 Issue Published: 1 April 1987 PDF downloadLoading ...
THU0003 Correlation of MIR-124 to Extracellular Matrix Protein MMP-3 in Patients with Rheumatoid Arthritis
Authors: N. Pavek, M. Pavkova Goldbergova, J. Lipkova, P. Nemec, J. Gatterova, J. Fedorko, M. Soucek, A. Vasku
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> MicroRNAs (miRNAs) are a 21 to 25 nucleotide long, small non-coding RNAs that post-transcriptionally regulate the expression of target genes, and thus modulate biological processes including cell differentiation, proliferation, apoptosis and invasion. <h3>Objectives</h3> The aim of the study was to examine the relation among miR-124 and serum levels of selected cytokines and chemokines (IL-6, IL-13, IL-15, TNF-alpha, MCP-1, RANTES), MMP (MMP-3), production of auto-antibodies, and factors describing rheumatoid arthritis (RA) including DAS28 and Total Sharp score. <h3>Methods</h3> A total of 80 RA patients according to the ACR criteria, and 10 control subjects were recruited into the study. The measurements of miR-124 and U-6 expression, CRP, anti-CCP, presence of rheumatoid factors (RFs), radiographs of both hands with calculation of Total Sharp score (TSS), DAS28 and cytokines, chemokines and MMP levels in serum were obtained from all RA patients. <h3>Results</h3> miR-124 was down-regulated in RA patients compared to controls. The miR-124 expression correlated to MMP-3 levels (p &lt; 0.001). No relation of miR-124 expression to measures of RA activity (DAS28 score, p = 0.51; TSS, p = 0.89; X-ray stage, p = 0.58) and auto-antibodies (anti-CCP, p = 0.14; RF, p = 0.29; RF IgG, p = 0.63; RF IgA, p = 0.92; RF IgM, p = 0.70) was observed. Also no association to acute inflammatory markers (CRP, p = 0.25; IL-6, p = 0.91), other cytokine and chemokines (IL-13, p = 0.62; IL-15, p = 0.57; IL-8, p = 0.78; MCP-1, p = 0.37; RANTES, p = 0.47) was found. <h3>Conclusions</h3> In conclusion, we present a down-regulation of miR-124 in RA patients and its correlation to MMP-3 levels. <h3>Disclosure of Interest</h3> None Declared
Insects and Disease of Man.
Authors: Carroll Fox
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insulin resistance and membrane abnormalities
Authors: H. Candiloros, N. Zeghari, O. Ziegler, M. Donner, P. Drouin, Hermann Toplak, Wolfgang Graier, Peter Dittrich, UlrichN. Wiesmann, ThomasC. Wascher, AnnaF. Dominiczak, Lucilla Poston, Gordon Murray, Michael Small, Peter Tong, Trevor Thomas, K. George, M.M. Alberti
Journal: The Lancet (1995)
Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial
Authors: Jennifer A. Kanakry, Hailun Li, Lan L. Gellert, M. Victor Lemas, Wen-son Hsieh, Fangxin Hong, King L. Tan, Randy D. Gascoyne, Leo I. Gordon, Richard I. Fisher, Nancy L. Bartlett, Patrick Stiff, Bruce D. Cheson, Ranjana Advani, Thomas P. Miller, Brad S. Kahl, Sandra J. Horning, Richard F. Ambinder
Journal: Blood (2013)
Two Cases of Cholecystotomy
Authors: J. K. Thornton
Journal: BMJ (1887)

will not strike it at the very beginning of the act of impulse, but just at the instant when the full force of the apex beat has been com- municated to the wire.It is easier to use this appliance along with the binaural stethoscope, as the operator can thus have the use of his eyes in adjusting the mechanism.After fixing the disc and wire in situ it is advisable to apply the stethoscope, and listen carefully for a few moments to the heart sounds before bringing the wire in contact with the wood.In this way the intensity and quality of the sounds or murmurs, and the length of the pauses, etc., can be examined and appreciated when,the sl4arp rap of the wire on the wood being induced, the rhythm will be demonstrated..7. g )% $l h i d Ufru,w Sit d; a,Xb B {ts,60'> '.: .r v-foil I -Zsi0bicoQ.* 2it @2 ,+ iD'j4 1 ( lTf.; a a s t i-t£a idle ,tad zsq 111.WAIsJ lof 1r-siU $itr >x s~.U (sqo9e fhiik 1 o' J on o wAi eenjs^i M q iI :ss\ '#e-d-w^r.rh t1 i'dm ( aSa id pir!o yv-AS .( ifSJCiP z4If141t1
P91 Dual mechanism of NK cell inhibition by the HCV core 35-44 peptide
Authors: K. S. Cheent, S. I. Khakoo
Journal: Gut (2011)

<h3>Introduction</h3> Disease association studies have shown that the inhibitory killer cell immunoglobulin receptor KIR2DL3 and its HLA-C1 allotype ligands are protective against chronic HCV infection. A number of studies have shown increased expression of another inhibitory natural killer (NK) cell receptor, CD94:NKG2A, in chronic HCV infection. The ligand for this receptor, HLA-E, usually binds to leader peptides derived from other HLA class I molecules. Up-regulation of HLA-E with concomitant inhibition of NK cells has been thought to be induced by peptides derived from several viruses including one derived from HCV (HCV core<sub>35–44</sub>) which thus represents a mechanism of immune escape. <h3>Method</h3> To determine the effects of viral peptides on NK cell inhibition, we pulsed the TAP-deficient 721.174 cell line with host and virus derived peptides and used these as target cells in flow cytometry assays of NK cell degranulation (measured by CD107a expression). <h3>Results</h3> In functional experiments HCV core<sub>35–44</sub> inhibited degranulation of the total NK cell population. Unexpectedly, this was due to inhibition of KIR2DL2/3-positive NK cells (one way ANOVA p&lt;0.0001), but not NKG2A-positive NK cells (p=0.94). However, HCV core<sub>35–44</sub> peptide increased cell surface expression of both HLA-C and HLA-E. To rationalise this with the previous findings we performed peptide mix experiments using the natural peptide ligands for HLA-E. Such peptides, derived from the leader sequence of host HLA class I molecules, efficiently inhibited NKG2A-positive NK cells. In the presence of a low concentration of a host HLA class I leader sequence peptide, HCV core<sub>35–44</sub> had a synergistic effect in suppressing NK cell activity (p&lt;0.0001). A synergistic effect at CD94:NKG2A was also demonstrable for peptides derived from EBV and HIV viruses, which in isolation did not inhibit NK cells, implying that this is a general mechanism for NK cell inhibition. <h3>Conclusion</h3> HCV core<sub>35–44</sub> inhibits NK cell activity via two distinct mechanisms, directly via KIR2DL2/3, and synergistically via the CD94:NKG2A receptor. This synergistic interaction at CD94:NKG2A represents a novel mechanism for inhibiting NK cells. It demonstrates the sensitivity of NK cells to small changes in the peptide content of HLA class I, and is thus potentially a sensitive mechanism for viral escape from the host innate immune response.
Pharmacological effects of alpha-methyldopa, alpha-methylnorepinephrine, and octopamine on rat arteriolar, arterial, and terminal vascular smooth.
Authors: B M Altura
Journal: Circulation Research (1975)

Experiments on rat mesenteric arterioles, metarterioles, and aortae demonstrate that although alpha-methylnorepinephrine is much less potent in inducing contraction than epinephrine on all three blood vessel types, it is either equivalent or only one and a half to two times less potent than the natural postganglionic neurotransmitter, norepinephrine, on these blood vessels. Furthermore, alpha-methylnorepinephrine is equivalent to norepinephrine in its ability to induce maximal contractile responses on rat arterioles, metarterioles, and aortae. Systemic administration of alpha-methyldopa to rats for 15 days shifted the log dose-response curves for all three catecholamines, but not vasopressin or potassium chloride, to the right of all three blood vessel types; the maximal contractile responses to these amines were, however, not affected by chronic treatment with alpha-methyldopa. In addition, acute, intra-arterial administration of 500 mg/kg of alpha-methyldopa was found not only to induce mesenteric arteriolar vasodilatation gradually but also to depress arteriolar reponsiveness to catecholamines. In view of these direct findings, it is difficult to accept the hypothesis that alpha-methyldopa induces hypotension via formation of a "false" postganglionic neurotransmitter substance, namely, alpha-methylnorepinephrine. The present findings suggest that alpha-methyldopa may exert some of its anti-hypertensive action, at least in the rat, by (1) depressing arteriolar responsiveness to circulating and released catecholamines and (2) some unknown direct action on peripheral vascular muscle. In addition, the present study indicates that octopamine is (1) between 60 and 15,000 times less potent than norepinephrine on rat arterioles and metarterioles and (2) incapable of eliciting more than a 40% occlusion of these terminal vessels. It is suggested that such data support the concept that octopamine, in contrast to alpha-methylnorepinephrine, could serve as a false adrenergic neurotransmitter agent and thus account for part or all of the hypotensive action of monoamine oxidase inhibitors like pargyline. The use of complete dose-response curves, several different adrenergic compounds (i.e., epinephrine, norepinephrine, alpha-methylnorepinephrine, octopamine, phenylephrine, and dopamine), and different rat blood vessels supports the concept that adrenergic molecules containing a catecholamine nucleus and a beta-hydroxyl group elicit the most potent constrictor responses from peripheral blood vessels. In addition, the data suggest that the structure-activity relationships for catecholamines and their analogs on terminal vascular smooth muscle are probably different from those for arterial smooth muscle.
A CASE OF INFANTILE ATRESIA OF THE NASAL FOSSÆ, WITH UNUSUALLY RAPID RESPIRATION.
Authors: GEO. C. STOUT
Journal: JAMA (1897)

Paul B., aged three months, was referred to me on Feb. 28, 1897. When born he was covered with eczematous scales, which at the time of his first visit had cleared up, with the exception of a few scaly areas on the scalp. He had been given bichlorid of mercury and iodid of potassium for the above condition by the mouth. He was apparently healthy and well nourished, but for the scales spoken of and his remarkably rapid breathing. His respirations were short and shallow, and numbered about 105 to the minute. His physician told me that he had had continuous rapid and noisy breathing since birth and occasionally had attacks simulating laryngismus stridulus. During these attacks his breathing became very labored; he became cyanotic, struggled for breath, and his condition became so alarming as to make recovery seem impossible. These attacks he had weekly, and at times oftener. It
Radionuclide Venography in the Upper Extremity
Authors: YUN U. RYO, JONG I. LEE, STEVEN M. PINSKY
Journal: Clinical Nuclear Medicine (1976)

Radionuclide venography with 99m Tc-MAA was performed on the upper limbs of two patients with clinical evidences of brachial vein thrombosis. The radionuclide venograms of one patient showed a flow defect at the axillary vein, abnormal collateral flows and stasis of radioactivity in a brachial vein. Contrast venography in this patient revealed extensive thrombosis in the axillary vein. The radionuclide venograms of the other patient showed impaired flow through the subclavian vein and abnormal collaterals. Contrast venography in this patient revealed a hypertrophic valve in the subclavian vein. Radionuclide venography of the upper limb is technically simple and is useful in the evaluation of suspected abnormalities in the deep veins of an upper extremity in a patient who is undergoing a perfusion lung scan or is allergic to contrast medium.
The Melamine Incident: Implications for International Food and Feed Safety
Authors: Céline Marie-Elise Gossner, Jørgen Schlundt, Peter Ben Embarek, Susan Hird, Danilo Lo-Fo-Wong, Jose Javier Ocampo Beltran, Keng Ngee Teoh, Angelika Tritscher
Journal: Environmental Health Perspectives (2009)

A major food safety incident in China was made public in September 2008. Kidney and urinary tract effects, including kidney stones, affected about 300,000 Chinese infants and young children, with six reported deaths. Melamine had been deliberately added at milk-collecting stations to diluted raw milk ostensibly to boost its protein content. Subsequently, melamine has been detected in many milk and milk-containing products, as well as other food and feed products, which were also exported to many countries worldwide.The melamine event represents one of the largest deliberate food contamination incidents. We provide a description and analysis of this event to determine the global implications on food and feed safety.A series of factors, including the intentional character of the milk contamination, the young age of the population affected, the large number of potentially contaminated products, the global distribution of these products, and the delay in reporting led this event to take on unexpected proportions. This incident illustrated the complexity of international trade of food products and food ingredients that required immediate actions at international level.Managing food-safety events should be done internationally and early on as soon as multinational consequences are expected. Collaboration between food-safety authorities worldwide is needed to efficiently exchange information and to enable tracking and recalling of affected products to ensure food safety and to protect public health.
Remember Barbara Starfield: primary care is the health system's bedrock
Authors: M. Caley
Journal: BMJ (2013)

<h3>Background</h3> Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a complex disease characterised by diagnosis and treatment delays. We applied a machine learning (ML) approach to explore new diagnostic signatures for JSLE based on immune-phenotyping data. <h3>Methods</h3> Immune-phenotyping of 28 T-cell, B-cell and myeloid-cell subsets in 67 age and sex-matched JSLE patients and 39 healthy controls (HCs) was performed by flow cytometry. A balanced random forest ML predictive model was developed (10,000 decision trees). 75% of sample data was randomly selected as a training set, the remaining 25% out-of-bag data was used for validation. Reciever operator characteristic, 10-fold cross validation, Sparse Partial Least Squares-Discriminant Analysis (sPLS-DA) and linear regression was used to validate the model. <h3>Results</h3> In JSLE, a global change in immunological architecture was established compared to HCs: many of the immune cell relationships identified in HCs using correlation comparison analysis were inverted or exacerbated in JSLE, including significantly inverted correlations between intermediate monocytes and memory B-cell populations and CD4/CD8 memory T-cells and B-cell memory in SLE versus HCs. Using immune-phenotyping data a ML model was developed and validated (accuracy=87.80%) showing that JSLE patients could be distinguished from HCs with high confidence using immunological parameters. The top variables contributing to the model included CD19<sup>+</sup> unswitched memory B-cells, naïve B-cells, CD14<sup>+</sup> monocytes and memory T-cell subsets. The ‘JSLE immune signature’ was also sucessfully validated using sPLS-DA and linear regression. To assess whether the validated signature could be used to further stratify JSLE patients, K-mean clustering was applied. Four JSLE groups each with a distinct immune and clinical profile were identified. Finally, network analysis identified specific clinical features associated with each of the top JSLE immune-signature variables. <h3>Conclusion</h3> Using a combined ML approach, a distinct immune signature was identified that discriminated between JSLE patients and HCs and further stratified patients. This signature could have diagnostic and therapeutic implications.
When Research Results Are in Conflict
Authors: John C. Bailar
Journal: New England Journal of Medicine (1985)

On rare occasions a journal can publish two research papers back-to-back, each appearing quite sound in itself, that come to conclusions that are incompatible in whole or in part. Such a conjunction can put critical issues involving research methods and interpretations in unusually sharp focus. I recall that the Journal published such papers in 19781 , 2 and 1982,3 , 4 each with a helpful editorial.5 , 6 In this issue we have another such pair.7 , 8 Stampfer et al.7 report that the use of postmenopausal hormones, primarily conjugated estrogens and nearly all unopposed by progestins, substantially protects women against nonfatal myocardial infarction and fatal coronary heart . . .
Analysis of prognostic variables in the prediction of mortality, shunt failure, variceal rebleeding and encephalopathy following the transjugular intrahepatic protosystemic stent-shunt for variceal haemorrhage
Authors: Rajiv Jalan, Robert A. Elton, Doris N. Redhead, Niall D.C. Finlayson, Hayes Peter C
Journal: Journal of Hepatology (1995)
The Production of Antibody against Human Leukocytic Pyrogen
Authors: Charles A. Dinarello, Lois Renfer, Sheldon M. Wolff
Journal: Journal of Clinical Investigation (1977)

Human peripheral blood leukocytes were stimulated with killed staphylococci in vitro to release leukocytic pyrogen (LP). Supernates from these stimulated leukocytes were concentrated, emulsified in Freund's complete adjuvant, and injected intradermally into rabbits. After seven monthly booster injections, rabbit antiserum destroyed the pyrogenic activity of human LP, and the titer of this neutralizing ability increased in the subsequent 7 mo. The pyrogen-neutralizing capacity of the rabbit antiserum was recovered in the globulin fraction, the IgG and IgM peaks of Sephadex G-200, and the acid-eluted fraction of a goat anti-rabbit IgG immunoadsorbant. The neutralizing antibody was specific for human LP inasmuch as it had no effect on rabbit, guinea pig, or monkey LP. When coupled to Sepharose, this antibody bound human LP; after acid elution from this immunoadsorbant, LP was recovered without loss of biologic or chemical characteristics. The antiserum was also absorbed with stimulated leukocyte supernates which did not contain LP, and this had no effect on the titer of anti-LP. Crude human LP, eluted from immunoadsorbant columns prepared from absorbed antiserum, contained significantly reduced contaminating protein when evaluated by polyacrylamide gel electrophoresis. These studies have established that specific antibody to human leukocytic pyrogen can be produced. This antibody is useful in the further study and purification of leukocytic pyrogen and its role in the pathogenesis of human fever.
Marihuana Use by Adolescents
Authors: Hugh H. Hussey
Journal: JAMA (1973)

Although studies conducted by questionnaire are sometimes suspect, Kandel's<sup>1</sup>evaluation of peer and parent influence on marihuana use by adolescents seems above reproach. Questionnaires were given in a random sample of homerooms in 13 high schools and to the entire student body in five other schools in New York State. Later a questionnaire was mailed to one parent of each student, alternately mothers and fathers. It was possible to match 49% of all the students to parents and 38% of the students in the five schools to their best school friends. In these five schools, 23% of students could be matched to parents as well as to their best school friends. Students were asked about their use of marihuana and about their perception of parents' use of psychoactive drugs. Parents were also asked about their own use of such drugs. There appeared a tendency for students to use marihuana
Ventilator-Associated Pneumonia
Authors: Janet M. Torpy, Cassio Lynm, Richard M. Glass
Journal: JAMA (2007)

Ventilator-Associated PneumoniaV entilator-associated pneumonia (VAP), defined as pneumonia (infection of the lung) occurring in a person who has been assisted by mechanical ventilation (a breathing machine) within the past 48 hours, is a serious and lifethreatening infection.Because individuals who contract ventilator-associated pneumonia are already critically ill (requiring mechanical ventilation), the death rate from ventilator-associated pneumonia is high.The April 11, 2007, issue of JAMA includes an article on ventilator-associated pneumonia.
Does the number of apoptotic cells in PBMC reveal the extent of impairment in T cell functionality?
Authors: Srividya Sundararaman, Marie Wunsch, Richard Caspell, Paul V Lehmann
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts As soon as PBMC are isolated cells start dying. The rate of apoptotic cell death increases when PBMC are shipped, cryopreserved or stored under suboptimal conditions. Apoptotic cells secrete mediators such as Lactoferrin that suppress inflammation while promoting phagocytosis. The