Repetitive Oral Activated Charcoal and Control of Emesis in Severe Theophylline Toxicity
Authors: Yona Amitai, Alan C. Yeung, Jack Moye, Frederick H. Lovejoy
Journal: Annals of Internal Medicine (1986)

Brief Reports1 September 1986Repetitive Oral Activated Charcoal and Control of Emesis in Severe Theophylline ToxicityYONA AMITAI, M.D., ALAN C. YEUNG, M.D., JACK MOYE, M.D., FREDERICK H. LOVEJOY Jr., M.D.YONA AMITAI, M.D.Search for more papers by this author, ALAN C. YEUNG, M.D.Search for more papers by this author, JACK MOYE, M.D.Search for more papers by this author, FREDERICK H. LOVEJOY Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-386 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTreatment with multiple doses of oral activated charcoal increases theophylline clearance in patients receiving theophylline therapy and in patients with mild theophylline toxicity (1-3). However, patients with severe theophylline toxicity have persistent vomiting and are unable to tolerate oral activated charcoal (3, 4). Theophylline may induce vomiting by increasing the volume of gastric secretion (5). The control of xanthine-induced gastric hypersecretion and vomiting therefore may include administration of H2 antagonists (6). We report the cases of two patients with severe theophylline toxicity and vomiting that was controlled by ranitidine and droperidol; multiple doses of oral activated charcoal were tolerated by...References1. BERLINGERSPECTORGOLDBERGJOHNSONQUEEBERG WRMGCM. Enhancement of theophylline clearance by oral activated charcoal. Clin Pharmacol Ther. 1983;33:351-4. CrossrefMedlineGoogle Scholar2. RADOMSKIPARKGOLDBERGSPECTORJOHNSONQUEE LGMRGC. Model for theophylline overdose treatment with oral activated charcoal. Clin Pharmacol Ther. 1984:35:402-8. CrossrefMedlineGoogle Scholar3. SESSLERGLAUSERCOOPER CFK. Treatment of theophylline toxicity with oral activated charcoal. Chest. 1985;87:325-9. CrossrefMedlineGoogle Scholar4. CORSERYOUNGSBAUGHMAN BCR. Prolonged toxicity following massive ingestion of sustained-release theophylline preparation. Chest. 1985;88:749-50. CrossrefMedlineGoogle Scholar5. JOHANNESSONANDERSSONJOELSSONPERSSON NKBC. Relaxation of lower esophageal sphincter and stimulation of gastric secretion and diuresis by antiasthmatic xanthines. Am Rev Respir Dis. 1985;131:26-30. MedlineGoogle Scholar6. CANOISENBERGGROSSMAN RJM. Cimetidine inhibits caffeine-stimulated gastric acid secretion in man. Gastroenterology. 1976;70:1055-7. CrossrefMedlineGoogle Scholar7. GAUDREAULTWASONLOVEJOY PSF. Acute pediatric theophylline overdose: a summary of 28 cases. J Pediatr. 1983;102:474-6. CrossrefMedlineGoogle Scholar8. VAUCHERLIGHTNERWALSON YEP. Theophylline poisoning. J Pediatr. 1977;90:827-30. CrossrefMedlineGoogle Scholar9. AMITAILOVEJOY YF. Relationship of vomiting to pharmacokinetics of sustained release theophylline in acute overdose: implication for management [Abstract]. Pediatr Res. 1986;20:177A. Google Scholar10. POWELLROGERSWARGINCROSSESHELMAN JJWRF. Inhibition of theophylline clearance by Cimetidine but not ranitidine. Arch Intern Med. 1984;144:484-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: YONA AMITAI, M.D.; ALAN C. YEUNG, M.D.; JACK MOYE, M.D.; FREDERICK H. LOVEJOYJr., M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdoseTheophylline and Other MethylxanthinesMethylxanthinesDecontamination of the Poisoned PatientClinical ToxicologyPOSITION STATEMENT AND PRACTICE GUIDELINES ON THE USE OF MULTI-DOSE ACTIVATED CHARCOAL IN THE TREATMENT OF ACUTE POISONINGTheophylline and CaffeineRisk Factors for Emesis After Therapeutic Use of Activated Charcoal in Acutely Poisoned ChildrenExtracorporeal therapies for acute intoxicationsTheophylline: Its rise, demise, and resurrectionPosition Statement and Practice Guidelines on the Use of Multi-Dose Activated Charcoal in the Treatment of Acute PoisoningComparative Efficacy of Hemodialysis and Hemoperfusion in Severe Theophylline IntoxicationTreatment of theophylline overdoseAcute and chronic human toxicity of theophyllinePrevention of drug absorption in simulated theophylline overdoseEffect of Multiple Doses of CharcoalMultiple-Dose Activated Charcoal: A Review of Relevant Clinical StudiesPrevention of Drug Absorption in Simulated Theophylline OverdoseConcepts and Controversies of Bronchodilator OverdoseOndansetron quells drug-resistant emesis in theophylline poisoningThe Use of Hemodialysis and Hemoperfusion in the Treatment of Theophylline IntoxicationTheophylline Toxicity in a Premature Neonate – Elimination Kinetics of Exchange TransfusionThe comparative efficacy of various multiple-dose activated charcoal regimensContaminated Commerical Charcoal as a Source of Fungi in the Respiratory TractMultiple doses of activated charcoal: Time for reappraisal?Role of Repeated Doses of Oral Activated Charcoal in the Treatment of Acute IntoxicationsThe assessment and treatment of theophylline poisoningExtracorporeal techniques in the treatment of exogenous intoxicationsCentral nervous system stimulants and anorectic agentsPoor tolerance of oral activated charcoal with theophylline overdoseRole of Extracorporeal Drug Removal in Acute Theophylline PoisoningActivated charcoal in management of poisoningCharacteristics of Vomiting Associated with Acute Sustained Release Theophylline Poisoning: Implications for Management with Oral Activated Charcoal 1 September 1986Volume 105, Issue 3Page: 386-387KeywordsChildrenTheophylline toxicityVomiting ePublished: 1 December 2008 Issue Published: 1 September 1986 PDF downloadLoading ...