tbuckley/cabot-search huggingface dataset:
Crystal deposition in hyperparathyroidism.
Authors: R Grahame, D J Sutor, M B Mitchener
Journal: Annals of the Rheumatic Diseases (1971)

The relationship between hyperparathyroidism and articular calcification is well established.It is based firstly on the finding of a high incidence of chondro- calcinosis in patients with hyperparathyroidism (18 per cent. of 91 cases: Dodds and Steinbach, 1968); and secondly on the appreciable numbers of cases of hyperparathyroidism found amongst large series of patients with chondrocalcinosis (McCarty, 1966, quoted a figure of up to 7 5 per cent.).There is also evidence of a significant though less clear-cut relationship between hyperparathyroidism and hyperuricaemia and gout.Mintz, Canary, Carreon, and Kyle (1961) observed hyperuricaemiain four out of eight patients with hyperparathyroidism; and Scott, Dixon, and Bywaters (1964) found eleven cases of hyperuricaemia (five with actual clinical gout) among twelve patients with hyperpara- thyroidism.Although renal impairment may have contributed to the hyperuricaemia in some cases, it seemed likely that the hyperparathyroidism per se was the underlying cause in several others.It follows, therefore, that a patient with hyper- parathyroidism is at risk of developing crystal- induced synovitis from either urate or calcium pyrophosphate or both; and there have been isolated reports of the recovery of appropriate crystals from the joint aspirate during episodes of acute synovitis (Jackson and Harris, 1965; Serre, Simon, Thevanet, and Barjon, 1966).However, a search of the literature has failed to reveal any combined morbid anatomical-crystallographic studies on patients with hyperparathyroid- FpTG.I Lateral radiograph of chest, showing calcification in region of mitral valve
Correlates of Midlife Career Achievement Among Women Physicians
Authors: Pirkko Lauslahti Graves
Journal: JAMA (1985)

In the context of a longitudinal study, we explored factors contributing to midlife career achievement among 108 women physicians. Three groups were formed, based on medical specialty, specialty board certification, and professorial appointment. Using analysis of variance procedures, the career groups were compared on measures obtained during medical school and on marital status, family size, and three health measures in midlife. Of the youthful measures, academic standing, father's socioeconomic status, and early family (specifically father-daughter) relationships were found to be associated with midlife achievement. Furthermore, a clear association was observed between success and good health in midlife. Married women formed the majority in all groups; no differences in family size were found. We conclude that career achievement among women physicians is influenced less by marriage and family size than by motivational and personality factors shaped in early life.
GMC accused of prejudicing doctors' defence
Authors: C. Dyer
Journal: BMJ (1997)

The General Medical Council (GMC) was accused last week of prejudicing the defence of three doctors accused of serious professional misconduct over heart surgery on babies and children.

Two consultant surgeons, James Wisheart and Janardan Dhasmana, are accused of carrying out operations beyond their technical competence when they were aware of concerns about high mortality, and the former executive of the United Bristol Healthcare Trust, John Roylance, is accused of allowing the operations to go ahead (18 October, p 967). Mr Wisheart, who was also the trust's medical director and who has since retired, is also accused of misleading parents about the risks of death or brain damage.

The charges relate to operations carried out between 1988 and 1995 at the Bristol Royal Infirmary on 53 babies and young children, of whom 29 died and four were left brain damaged. Concern centred particularly on arterial switch operations for transposition of the great arteries. The GMC hearing is to be followed by a government inquiry.

It emerged last week that the GMC sent “chapter XV letters” to three other Bristol consultants-two cardiologists …
THE MICRO-ANATOMY OF NORMAL SKIN AS SEEN IN THICK SECTIONS.
Authors: K. V. SANDERSON, HELGA THIEDE
Journal: British Journal of Dermatology (1961)

Journal Article THE MICRO‐ANATOMY OF NORMAL SKIN AS SEEN IN THICK SECTIONS. Get access K. V. SANDERSON, K. V. SANDERSON Institute of Dermatology, St. John's Hospital for Diseases of the Skin, London, W.C.2 Search for other works by this author on: Oxford Academic Google Scholar HELGA THIEDE HELGA THIEDE Adelaide Children's Hospital, South Australia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 73, Issue 2, 1 February 1961, Pages 43–56, https://doi.org/10.1111/j.1365-2133.1961.tb14406.x Published: 01 February 1961
Isohemagglutinins in Pooled Plasma
Authors: Marion R. Rymer
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The Journal(<b>201</b>: 562, 1967) published "Isohemagglutinins in Pooled Plasma" by K. B. McCall, PhD, who expressed surprise at the high titers reported by Oberman et al,<sup>1</sup>and stated that he had never observed a high titer (saline) plasma pool prepared by the Michigan Department of Health between 1943 and 1957 from outdated blood. He suggested that the higher titers noted by other workers may be the result of the newer methods of blood collection and plasma separation and that these gentler methods protect the red cells from disintegration, which presumably would liberate isohemagglutinogenic neutralizing substances A and B. However, Rutzky et al<sup>2</sup>reported high anti-A titers in commercially pooled plasma and stated "neither dilution in the pool nor neutralization by natural A substance in the component A plasmas can be relied upon." We have recently completed a study under National Institutes of Health Contract
Regulation of the Cell Cycle by Calcium and Calmodulin
Authors: KUN PING LU, ANTHONY R. MEANS
Journal: Endocrine Reviews (1993)

IN ORDER to reproduce and multiply, every cell must execute an orderly series of events, generally called the cell cycle, at some time during its life span. The cell cycle was first thought to consist of mitosis and interphase as determined from morphological analysis. As new techniques were developed, a period of DNA synthesis, the S phase, was detected; this was temporally separated from the previous mitosis by a "gap," the G1 phase, and from the subsequent mitosis by another "gap," the G2 phase (Fig. 1). The G1 phase is the decision phase in which cells either commit to undergo another round of DNA synthesis and continue to cycle or to exit the cell cycle to enter a quiescent state frequently referred to as G0. Cells in the G0 phase either terminally differentiate or resume proliferation upon addition of an appropriate mitogen (Fig. 1). When DNA synthesis is completed, cells normally proceed to mitosis. The regulation of this series of events is of primary interest to the endocrinologist, since precise control of cell fate is an essential element in hormone action. During the last decade, genetic analyses in fungi and biochemical studies in vertebrate and invertebrate species have resulted in identification of key regulatory proteins that specifically control progression through the decision points of the cell cycle. However, the overall process is very complicated, and control of cell proliferation is a result of a coordinated regulation of multiple biochemical pathways that integrate both intracellular and extracellular signals. Many critical components of these pathways remain to be elucidated.
An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors
Authors: Justin M Dean, Art Riddle, Jennifer Maire, Kelly D Hansen, Marnie Preston, Anthony P Barnes, Larry S Sherman, Stephen A Back
Journal: Molecular Neurodegeneration (2011)

CNS myelination disturbances commonly occur in chronic white matter lesions in neurodevelopmental and adult neurological disorders. Recent studies support that myelination failure can involve a disrupted cellular repair mechanism where oligodendrocyte (OL) progenitor cells (OPCs) proliferate in lesions with diffuse astrogliosis, but fail to fully differentiate to mature myelinating OLs. There are no in vitro models that reproduce these features of myelination failure.Forebrain coronal slices from postnatal day (P) 0.5/1 rat pups were cultured for 1, 5, or 9 days in vitro (DIV). Slices rapidly exhibited diffuse astrogliosis and accumulation of the extracellular matrix glycosaminoglycan hyaluronan (HA), an inhibitor of OPC differentiation and re-myelination. At 1 DIV ~1.5% of Olig2+ OLs displayed caspase-3 activation, which increased to ~11.5% by 9 DIV. At 1 DIV the density of PDGFRα+ and PDGFRα+/Ki67+ OPCs were significantly elevated compared to 0 DIV (P < 0.01). Despite this proliferative response, at 9 DIV ~60% of white matter OLs were late progenitors (preOLs), compared to ~7% in the postnatal day 10 rat (P < 0.0001), consistent with preOL maturation arrest. Addition of HA to slices significantly decreased the density of MBP+ OLs at 9 DIV compared to controls (217 ± 16 vs. 328 ± 17 cells/mm2, respectively; P = 0.0003), supporting an inhibitory role of HA in OL lineage progression in chronic lesions.Diffuse white matter astrogliosis and early OPC proliferation with impaired OL maturation were reproduced in this model of myelination failure. This system may be used to define mechanisms of OPC maturation arrest and myelination failure related to astrogliosis and HA accumulation.
A History of Medical Psychology
Authors: Gregory Zilboorg, George William Henry
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pancreatic Cancer Stem Cells
Authors: Cheong J. Lee, Joseph Dosch, Diane M. Simeone
Journal: Journal of Clinical Oncology (2008)

Cellular heterogeneity in cancer was observed decades ago by studies in mice which showed that distinct subpopulations of cells within a tumor mass are capable of driving tumorigenesis. Conceptualized from this finding was the stem-cell hypothesis for cancer, which suggests that only a specific subset of cancer cells within each tumor is responsible for tumor initiation and propagation, termed tumor initiating cells or cancer stem cells (CSCs). Recent data has been provided to support the existence of CSCs in human blood cell–derived cancers and solid organ tumors of the breast, brain, prostate, colon, and skin. Study of human pancreatic cancers has also revealed a specific subpopulation of cancer cells that possess the characteristics of CSCs. These pancreatic cancer stem cells express the cell surface markers CD44, CD24, and epithelial-specific antigen, and represent 0.5% to 1.0% of all pancreatic cancer cells. Along with the properties of self-renewal and multilineage differentiation, pancreatic CSCs display upregulation of important developmental genes that maintain self-renewal in normal stem cells, including Sonic hedgehog (SHH) and BMI-1. Signaling cascades that are integral in tumor metastasis are also upregulated in the pancreatic CSC. Understanding the biologic behavior and the molecular pathways that regulate growth, survival, and metastasis of pancreatic CSCs will help to identify novel therapeutic approaches to treat this dismal disease.
Needlestick Transmission of Hepatitis C
Authors: Mark S. Sulkowski
Journal: JAMA (2002)

Hepatitis C virus (HCV) transmission following a needlestick is an important threat to health care workers. We present the case of a 29-year-old medical intern who sustained a needlestick injury from a source patient known to be infected with both human immunodeficiency virus and HCV. The case patient subsequently developed acute HCV infection. The optimal strategy for diagnosing HCV infection after occupational exposures has not been defined. At a minimum, HCV antibody and alanine aminotransferase testing should be done within several days of exposure (to assess if the health care worker is already infected with HCV) and 6 months after percutaneous, mucosal, or nonintact skin exposure to blood or infectious body fluids from an HCV-infected patient. Currently, it is not possible to prevent HCV infection after exposure. However, recent data suggest that early treatment of acute HCV infection with interferon α may be highly effective in preventing chronic HCV infection. These data underscore the importance of identifying persons with acute HCV infection and promptly referring them to experienced clinicians who can provide updated counseling and treatment.
Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors
Authors: Shashank R. Sirsi, Sonia L. Hernandez, Lukasz Zielinski, Henning Blomback, Adel Koubaa, Milo Synder, Shunichi Homma, Jessica J. Kandel, Darrell J. Yamashiro, Mark A. Borden
Journal: Journal of Controlled Release (2011)
RECEPTORS FOR HISTAMINE IN HUMAN SKIN BLOOD VESSELS: A REVIEW
Authors: Malcolm Greaves, Robin Marks, Ivan Robertson
Journal: British Journal of Dermatology (1977)

Journal Article RECEPTORS FOR HISTAMINE IN HUMAN SKIN BLOOD VESSELS: A REVIEW Get access Malcolm Greaves, Malcolm Greaves Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar Robin Marks, Robin Marks Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar Ivan Robertson Ivan Robertson Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue 2, 1 August 1977, Pages 225–228, https://doi.org/10.1111/j.1365-2133.1977.tb15071.x Published: 01 August 1977
Adverse reactions during treatment with amiodarone hydrochloride.
Authors: A Samanta, G R Jones, A C Burden
Journal: BMJ (1983)

503diagnosis and several more had raised blood pressure on admission to hospital.'In our series a low blood pressure or low pulse pressure was unusual, even in cases of severe aortic stenosis, although the pulse waveform was almost always abnormal.We believe that the coexistence of aortic stenosis and hyper- tension ismore than chance and it may be that raised systemic pressure accelerates wear of the aortic valve, especially if it is congenitally bicuspid.
Sleep Inducement by L-Tryptophan
Authors: Hugh H. Hussey
Journal: JAMA (1974)

When a hearty meal induces drowsiness, it is because blood leaves the brain and goes to the stomach (gut). Surely you have heard your mother or your grandmother or somebody tell that old wives' tale, and maybe you believed it. It is nonsense, according to Hartmann et al in a report appearing in the current issue of Archives of General Psychiatry (31:394-397, 1974).  Complete hydrolysis of proteins yields some 20 different amino acids some of which are essential or  in that they serve important functions but cannot be synthesized by the body. Among the indispensable amino acids derived from food is L-tryptophan, which, among other actions, in animals and man has been shown to induce sleep, presumably by raising blood levels of serotonin.  Accordingly, Hartmann et al undertook a sleep-laboratory study of the effects of L-tryptophan on sleep latency (the time from lights out until sleep) in a group
Benzoyl peroxide/clindamycin/UVA is more effective than fluticasone/UVA in progressive macular hypomelanosis: A randomized study
Authors: Germaine N. Relyveld, Melanie M. Kingswijk, Johannes B. Reitsma, Henk E. Menke, Jan D. Bos, Wiete Westerhof
Journal: Journal of the American Academy of Dermatology (2006)
The direct and indirect costs of explosive violence
Authors: C. Buhmann
Journal: BMJ (2009)

Violent conflict remains a major risk to human health and explosive weapons are an important cause of death and injury in such situations. The health consequences are devastating. Explosive weapons cause death, injury, and psychological disabilities. They also cost lives through their effects on the health system, human resources in health, water and sanitation systems, electricity supplies, and the general diversion of human and economic resources away from health planning and health services towards defence and securing stability. A new report published by Landmine Action aims to place explosive violence on the policy agenda. For six months data on death and injury from explosive weapons were collected from media reports. 58 countries had incidents of explosive violence, but most of the incidents took place in only a few countries. Most victims were civilians, among whom women and children were over-represented. Language: en
Venous leg ulcers.
Authors: A Prasad
Journal: BMJ (1993)

ance of immunological tolerance to these natural compounds.'Under conditions of autoimmunity, such as experimentally induced immune mediated demyelination of the peripheral nerves, injections of pure gangliosides do not result in the induction of antibodies to gangliosides and do not worsen the course of the disease.7A neurological syndrome induced in rabbits by injecting gangliosides derived from brain reported by Nagai et at could not be reproduced and could be explained as resulting from contamination of the ganglioside preparation by myelin proteins.Antibodies reactive with gangliosides recognise the carbohydrate portion of the molecule.These carbohydrate epitopes are not uniquely expressed on gangliosides but are also present on glyco- proteins and bacterial cell walls.9Controlled studies in humans have proved that the prolonged administration of Gmi in healthy individuals as well as in patients with neurological diseases does not modify the pattern of antibody crossreactivity to glycoconjugates.'°In conclusion, all available data are consistent with the lack of immunogenicity of brain-derived gangliosides if purity is guaranteed.Thus, their use for therapeutic purpose should not be restricted by the present immunological knowledge.
Chronic Anemia due to Gastric Ectopia within the Duodenum
Authors: P. Canelles, E. Orti, A. Tome, V. Garcia, E. Medina
Journal: Endoscopy (1992)

See also: Heterotopic Gastric (Fundic) Mucosa in the DuodenumEndoscopy 1982; 14(05): 166-167DOI: 10.1055/s-2007-1021610
Report: Too Little Surveillance, Treatment for US Patients With Hepatitis B and C
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CHOLERA WEATHER
Authors: J. A. Hingeston
Journal: BMJ (1856)

T IIDICAL JOURNAL[AvGUu 2,X1lwewe ought togethe as the prous ca; no lits dt vws wer requid; and, der the effects of chioro fern, tne Amight conceive no operation at all was going on.The venerable and deservedly esteemed senior surgeon of S. Bartholomew's remarked, that a new era in surgery had opened, of which he had little dreamed-a large tumour, the ase of a child's head, being removed from the most sensitive part of the female system, without bleeding, without knives or ligatus, without pain!
Bivalent histone modifications during tooth development
Authors: Li-Wei Zheng, Bin-Peng Zhang, Ruo-Shi Xu, Xin Xu, Ling Ye, Xue-Dong Zhou
Journal: International Journal of Oral Science (2014)

Histone methylation is one of the most widely studied post-transcriptional modifications. It is thought to be an important epigenetic event that is closely associated with cell fate determination and differentiation. To explore the spatiotemporal expression of histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 27 trimethylation (H3K27me3) epigenetic marks and methylation or demethylation transferases in tooth organ development, we measured the expression of SET7, EZH2, KDM5B and JMJD3 via immunohistochemistry and quantitative polymerase chain reaction (qPCR) analysis in the first molar of BALB/c mice embryos at E13.5, E15.5, E17.5, P0 and P3, respectively. We also measured the expression of H3K4me3 and H3K27me3 with immunofluorescence staining. During murine tooth germ development, methylation or demethylation transferases were expressed in a spatial–temporal manner. The bivalent modification characterized by H3K4me3 and H3K27me3 can be found during the tooth germ development, as shown by immunofluorescence. The expression of SET7, EZH2 as methylation transferases and KDM5B and JMJD3 as demethylation transferases indicated accordingly with the expression of H3K4me3 and H3K27me3 respectively to some extent. The bivalent histone may play a critical role in tooth organ development via the regulation of cell differentiation. Maps of chromosomal modifications could help scientists to better understand the timing and organization of tooth development. Chromosomal DNA is arranged around proteins called histones, which can be chemically modified at different sites. These modifications can boost or suppress gene activity, and researchers led by Xue-Dong Zhou of Sichuan University set out to examine their involvement in tooth formation. They examined two different histone modifications, one activating and one suppressing, at five different time-points in pulp and enamel development. They found that many sites in the young tooth exhibit both modifications, a state believed to prime cells to respond rapidly to developmental signals. Indeed, immature cells showed gene-activating modifications while more developed enamel and pulp cells tended to show inhibitory modifications. Closer examination of these patterns could lead to a more detailed timeline of tooth development.