tbuckley/cabot-search huggingface dataset:
Mycoplasmas and human arthritis.
Authors: E Jansson, K Hakkarainen, A Miettinen, K Kaitila, M Karppelin
Journal: Annals of the Rheumatic Diseases (1991)

Mean (SD) plasma endothelin-1 concentration in 28 patients wnth systemic lupus erythematosus: correlating factors (results given as number of patients) Group Endothelin-1 plasma Nephritist Raynaud's Anticardiolipin concentration (pg/ml) phenomenon antibodies Al patients (n=28) 10-8 (5O0)... 15 9 9Normal endothelin-l concentrationt (n=5) 3-2 (2-0)High endothelin-l concentrations (n=23) (3-8) 14* 8 8 Healthy subjects (n=66) 2-9 (1-2) 0 0 Not done *p<0.05 v paients with systemic lupus erythematosus with nornal endothelin-1 concentrations;** *p<0001 v healthy controls.tProteiunuria >0 5 g/day during some period of the disease.Biopsy done in 13 patients (see text).tPlasma endothelin-I concentration <5-3 pg/ml.§Plasma endothelin-1 concentration >5 3 pg/ml.not reach statistical significance, but is in- teresting.Anticardioplipin antibodies are di- rected against platelets9 and endothelial cells'0 and may contribute to endothelial endothelin- 1 production.The increase of plasma endothelin-1 in patients with systemic lupus erythematosus found in this study suggests that endothelin-1 may play a part in the pathophysiology of systemic lupus erythematosus.The associa- tion with nephritis is intriguing, but needs further evaluation.
Psychiatric Comorbidity of Gender Identity Disorders: A Survey Among Dutch Psychiatrists
Authors: Joost à Campo, Henk Nijman, H. Merckelbach, Catharine Evers
Journal: American Journal of Psychiatry (2003)

OBJECTIVE: In the Netherlands, it is considered good medical practice to offer patients with gender identity disorder the option to undergo hormonal and surgical sex reassignment therapy. A liberalization of treatment guidelines now allows for such treatment to be started at puberty or prepuberty. The question arises as to what extent gender identity disorder can be reliably distinguished from a cross-gender identification that is secondary to other psychiatric disorders. METHOD: The authors sent survey questionnaires to 382 board-certified Dutch psychiatrists regarding their experiences with diagnosing and treating patients with gender identity disorder. RESULTS: One hundred eighty-six psychiatrists responded to the survey. These respondents reported on 584 patients with cross-gender identification. In 225 patients (39%), gender identity disorder was regarded as the primary diagnosis. For the remaining 359 patients (61%), cross-gender identification was comorbid with other psychiatric disorders. In 270 (75%) of these 359 patients, cross-gender identification was interpreted as an epiphenomenon of other psychiatric illnesses, notably personality, mood, dissociative, and psychotic disorders. CONCLUSIONS: These data suggest that there is little consensus, at least among Dutch psychiatrists, about diagnostic features of gender identity disorder or about the minimum age at which sex reassignment therapy is a safe option. Therapy options proposed to patients with gender identity disorder appear to depend on personal preferences of psychiatrists. These results underline the need for more specific diagnostic rules in this area.
Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings
Authors: Kaoru Murakami, Hiroshi Aoki, Shingo Nakamura, Shin-ichiro Nakamura, Megumi Takikawa, Motoaki Hanzawa, Satoko Kishimoto, Hidemi Hattori, Yoshihiro Tanaka, Tomoharu Kiyosawa, Yasunori Sato, Masayuki Ishihara
Journal: Biomaterials (2009)
ELECTRON MICROSCOPE STUDY OF SURFACE IMMUNOGLOBULIN-BEARING HUMAN TONSIL CELLS
Authors: Dorothea Zucker-Franklin, Steven Berney
Journal: The Journal of Experimental Medicine (1972)

Surface immunoglobulin-bearing cells were selected from suspensions of human tonsil cells by the reverse immune cytoadherence technique. The method employed a hybrid antibody directed against Ig on lymphoid cells and against ferritin bound to sheep red blood cells (SRBC). Only 6% of the cells formed rosettes. When subjected to electron microscopy they were shown to consist of a morphologically heterogeneous population of cells. However, most cells in the center of rosettes showed ribosome-associated endoplasmic reticulum (RER) and polyribosomes. Usually these organelles were located in close proximity to membrane sites where a 400–600 A bridge was resolved between the lymphocyte and the ferritin particle on the SRBC. The bridge is postulated to consist at least in part of Ig. Only 50% of the plasma cells formed rosettes and bridges could not be resolved. The surface of the plasma cells within rosettes differed from that of plasma cells which had not reacted with ferritin-coated sheep erythrocytes. The incidence of plasma cells and γ-globulin-bearing lymphoid cells was corroborated with the help of fluorescent antibody techniques.
Intestinal paracellular peptide transport: mobilization of intracellular calcium as a mechanism of tight junctional opening by 4-phenylazobenzoxycarbonyl–Pro–Leu–Gly–Pro–d-Arg (Pz-peptide) in the rabbit descending colon and Caco-2 cell monolayers
Authors: Wan-Ching Yen, Yoshinobu Higashi, Vincent H.L Lee
Journal: Journal of Controlled Release (1997)
ON THE DISEASES OF THE EAR PREVAILING IN LANCASHIRE AND CHESHIRE
Authors: W. C. Williamson
Journal: BMJ (1856)

p.tient relief; but, fearing an interruption to the cure, and th.man volunteering to continue presure, I determined to persevere until the morrow.The following morning, I was agreeably surprised at being told that three hours after seeig him on the previous day, when loosening the compressor for readjustment, he found that the tumour did not pulsate, and that it had not done so since.Examination proved this to be correct; the tumour felt solid, free from impulse, and there was no bruit audible.The pressure was lightly applied during the next twenty-four hours, and then (January 15th) entirely
Endometriosis is associated with an increased risk of ovarian cancer, study shows
Authors: A. Sundaralingam
Journal: BMJ (2012)

Women who have endometriosis are substantially more likely to develop three distinct histological subtypes of ovarian cancer: clear cell, endometrioid, and low grade serous, research in Lancet Oncology shows (doi:10.1016/S1470-2045(11)70404-1).

Previous studies have shown an association between endometriosis and invasive epithelial ovarian cancer (the most fatal malignancy of the female reproductive system) but have failed to characterise the relation.

Lead author …
Bovine spongiform encephalopathy: its wider meaning for population health
Authors: A J Mcmichael
Journal: BMJ (1996)

almost all studies but are unlikely to explain the observed effects; indeed loss to follow up of more severely affected individuals may have caused some bias towards showing no effect.Differences between studies may be due to the different organophosphates studied.The observed peripheral effects are consistent with persistent delayed neuropathy induced by organophosphate.The mechanism by which chronic central nervous system effects might occur is unknown; Duffy et al have observed persistent changes on electroencephalograms after high level exposure."1Clinical neurological examinations have given negative results in the subjects studied epidemiologically.The importance of the 1 Cherniak M. Toxicological screening for organophosphorus-induced delayed neurotoxicity: complications in toxicity testing.
<i>SYNE1</i>Mutations in Autosomal Recessive Cerebellar Ataxia
Authors: Anne Noreau, Cynthia V. Bourassa, Anna Szuto, Annie Levert, Sylvia Dobrzeniecka, Julie Gauthier, Sylvie Forlani, Alexandra Durr, Mathieu Anheim, Giovanni Stevanin, Alexis Brice, Jean-Pierre Bouchard, Patrick A. Dion, Nicolas Dupré, Guy A. Rouleau
Journal: JAMA Neurology (2013)

<h3>Importance</h3> Autosomal recessive cerebellar ataxia type I, also known as recessive ataxia of Beauce, is a slowly progressive ataxia that leads to moderate disability with gait ataxia, dysarthria, dysmetria, mild oculomotor abnormalities, and diffuse cerebellar atrophy on brain imaging. Mutations in the synaptic nuclear envelope protein 1 (<i>SYNE1</i>) gene, located on chromosome 6p25, were first reported in patients who originated from a region known as “Beauce” in the province of Quebec, Canada. <h3>Objective</h3> To better evaluate the prevalence of<i>SYNE1</i>mutations in individuals with mild pure cerebellar ataxia and cerebellar atrophy, we screened the gene in additional French-Canadian (FC) families and individuals from other populations. <h3>Design, Setting, and Participants</h3> Study participants were referred by their treating physician on the basis of core features of autosomal recessive cerebellar ataxia type I. After excluding individuals with known<i>SYNE1</i>mutations, our cohort was composed mainly of 19 FCs and 21 individuals from other ethnic backgrounds. <h3>Interventions</h3> Extraction of DNA from blood samples and complete resequencing of the<i>SYNE1</i>gene. <h3>Main Outcomes and Measures</h3> The involvement of<i>SYNE1</i>mutations in individuals with ataxia worldwide by resequencing the<i>SYNE1</i>gene. <h3>Results</h3> Two novel truncating mutations were found among the FC participants, and 2 other novel mutations were found in a patient from France and a patient from Brazil (1 mutation each). <h3>Conclusions and Relevance</h3> This is the second report, to our knowledge, of<i>SYNE1</i>gene mutations in a population other than FCs. These data suggest that mutations in<i>SYNE1</i>should be investigated in families with cerebellar ataxia who live outside the FC region.
Problems in the Evaluation of Carcinogenic Hazard from Use of Food Additive
Authors: Walter Wolman
Journal: JAMA (1960)

The difficulties of determining the carcinogenic activity of a substance for man are recognized for the most part in a general way. This brief and well-written booklet might be read with benefit by all physicians who wish to understand some of the specific reasons for the difficulties. The text briefly discusses terminology and definitions, strong and weak carcinogens, and general principles, such as comparative carcinogenicity (species and route of administration) and dose response. There follows a section on evaluation of the carcinogenicity of food additives in which are discussed the many problems involved in setting up adequate tests for carcinogenicity. These include brief and compact presentations on selection of species, sex and age of test animals, diet, dosage and dose response, use of control groups, character of the samples under test, group size and significance of results, routes of administration, pathological evaluation, and short-term test procedures. On the basis of
The New Language of Hospital Management
Authors: Philip R. Alper
Journal: New England Journal of Medicine (1984)

Once upon a time we were merely the Community Hospital. That worthy institution was run by an Administrator who was helped by an Assistant Administrator and by a Chief of Nurses, Head Pharmacist, Director of Central Supply, and so forth. In those primitive days, it was possible to know by a glance at the titles what everyone did.We began our experimentation with titles a few years ago when we decided to rename ourselves Community Hospital and Medical Center. The absence of teaching and research, the usual hallmarks of a medical center, weighed less in the decision than our pride . . .
The Reform of Sick Nursing and the late Mrs. Wardroper
Authors: F. Nightingale
Journal: BMJ (1892)

MRS. GAMP.ONE has passed away without noise, without crown or sceptre of martyrdom, who was the pioneer of hospital nursing, the first lay hospital matron, at least of a great public hospital, who was a gentlewoman.Her kingdom was that of the sick.No public press heroine was she; yet countless sick will bless *her name though they never heard it, and she opened a new calling for women of all classes, the Nursing Institutions for the Poor.She did this-a great work-for her country and her Sovereign, who is the mother of English-speaking woman- kind, thrice blessed to those for whom it initiated a divine life of common sense in nursing.No Mrs. Gamp could live in her neighbourhood; Mrs. Gamp was extinct for ever.She was soon gladly acknowledged by the doctors as their chief in nursing.She led a hard life,
Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Authors: Valeria R. Fantin, Andrey Loboda, Cloud P. Paweletz, Ronald C. Hendrickson, Jacqueline W. Pierce, Jennifer A. Roth, Lixia Li, Frank Gooden, Susan Korenchuk, Xiaoli S. Hou, Elizabeth A. Harrington, Sophia Randolph, John F. Reilly, Christopher M. Ware, Marshall E. Kadin, Stanley R. Frankel, Victoria M. Richon
Journal: Cancer Research (2008)

Abstract Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in ∼30% of patients with advanced mycosis fungoides and Sézary syndrome cutaneous T-cell lymphoma (CTCL). The purpose of this study was to identify biomarkers predictive of vorinostat response in CTCL using preclinical model systems and to assess these biomarkers in clinical samples. The signal transducer and activator of transcription (STAT) signaling pathway was evaluated. The data indicate that persistent activation of STAT1, STAT3, and STAT5 correlate with resistance to vorinostat in lymphoma cell lines. Simultaneous treatment with a pan-Janus-activated kinase inhibitor resulted in synergistic antiproliferative effect and down-regulation of the expression of several antiapoptotic genes. Immunohistochemical analysis of STAT1 and phosphorylated tyrosine STAT3 (pSTAT3) in skin biopsies obtained from CTCL patients enrolled in the vorinostat phase IIb trial showed that nuclear accumulation of STAT1 and high levels of nuclear pSTAT3 in malignant T cells correlate with a lack of clinical response. These results suggest that deregulation of STAT activity plays a role in vorinostat resistance in CTCL, and strategies that block this pathway may improve vorinostat response. Furthermore, these findings may be of prognostic value in predicting the response of CTCL patients to vorinostat. [Cancer Res 2008;68(10):3785–94]
New HPV Vaccine Provides Wider Protection
Authors: Anita Slomski
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In search of cyclooxygenase inhibitors, anti-Mycobacterium tuberculosis and anti-malarial drugs from Thai flora and microbes
Authors: George A. Gale, Kanyawim Kirtikara, Pattama Pittayakhajonwut, Somsak Sivichai, Yodhathai Thebtaranonth, Chawanee Thongpanchang, Vanicha Vichai
Journal: Pharmacology & Therapeutics (2007)
Long-Term Endothelin A Receptor Blockade Inhibits Electrical Remodeling in Cardiomyopathic Hamsters
Authors: Yasunori Matsumoto, Hajime Aihara, Rikako Yamauchi-Kohno, Yoshie Reien, Takehiko Ogura, Hideo Yabana, Yoshiaki Masuda, Toshiaki Sato, Issei Komuro, Haruaki Nakaya
Journal: Circulation (2002)

Background — The endothelin (ET) system is activated in failing hearts. Congestive heart failure frequently is associated with ventricular arrhythmias, which may result from electrical remodeling such as changes of ionic current density and heterogeneous action potential prolongation. We examined the effects of long-term ET A receptor blockade on the electrophysiological properties of ventricular cells, the surface ECG, and the survival in BIO 14.6 cardiomyopathic hamsters. Methods and Results — Membrane currents and action potentials were recorded from left ventricular cells isolated from normal F1β hamsters and cardiomyopathic BIO 14.6 hamsters untreated and chronically treated with TA-0201, an ET A receptor antagonist. In ventricular cells of untreated BIO 14.6 hamsters, the action potential duration was prolonged and the densities of the L-type Ca 2+ current ( I Ca,L ), the transient outward current ( I to ), the delayed rectifier K + current ( I K ), and the inward rectifier K + current ( I K1 ) were decreased compared with those of F1β hamsters. Long-term treatment with the ET A receptor antagonist significantly attenuated action potential duration prolongation and reduction of I to , I K , and I Ca,L in BIO 14.6 ventricular cells. Long-term ET A receptor blockade prevented the QT prolongation and ventricular arrhythmias and improved the survival rate in the cardiomyopathic hamsters. Conclusions — Long-term treatment with an ET A antagonist inhibits electrical remodeling such as downregulation of K + and Ca 2+ currents, action potential prolongation, and the increased QT interval and thereby suppresses ventricular arrhythmias in cardiomyopathic hearts. ET A receptor blockade may provide a new strategy for the prevention of ventricular arrhythmias associated with heart failure.
Neuroblastoma screening does not reduce mortality
Authors: A. Tuffs
Journal: BMJ (2002)

Two studies from Canada and Germany published last week provide clear evidence that children aged 1 year or younger should not be screened for neuroblastoma, because mortality is not reduced by mass screening ( New England Journal of Medicine 2002;346:1041-6 and 1047-53).

On the contrary, screening may have adverse effects, the researchers say, because it detects early cases of the tumour that probably would have remitted spontaneously without treatment. The German study reported three deaths that were due to …
Predictive factors and outcome of hepatorenal syndrome in cirrhosis. Relevance of serum sodium concentration
Authors: O. Ozdogan, M. Guevara, P. Gines, C. Alessandria, T. Restuccia, D. de las Heras, J. Colmenero, B. Calahorra, V. Arroyo, J. Rodes
Journal: Journal of Hepatology (2003)
Reporting Enrollment in Clinical Trials
Authors: Cary P. Gross
Journal: Annals of Internal Medicine (2002)

Letters17 December 2002Reporting Enrollment in Clinical TrialsCary P. Gross, MD and Harlan Krumholz, MDCary P. Gross, MDYale School of Medicine; New Haven, CT 06520Search for more papers by this author and Harlan Krumholz, MDYale School of Medicine; New Haven, CT 06520Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-12-200212170-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Halpern emphasizes that both qualitative and quantitative information on the enrollment process is needed to help clinicians apply trial results to individual patients. We strongly agree. Detailed clinical information about patients who were eligible but elected not to participate could yield important information about the degree of selective enrollment and the impact of this selectivity on applicability. As we mentioned in our article, however, it is not always possible for investigators in large multicenter trials to gather this information. Further developments that can facilitate these activities will be of great benefit.Friedman raises the important issue of the ...References1. Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, et al . Improving the quality of reporting of randomized, controlled trials. The CONSORT statement. JAMA. 1996;276:637-9. [PMID: 8773637] CrossrefMedlineGoogle Scholar2. Moher D, Schulz KF, Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA. 2001;285:1987-91. [PMID: 11308435] CrossrefMedlineGoogle Scholar3. Egger M, Jüni P, Bartlett C. Value of flow diagrams in reports of randomized, controlled trials. JAMA. 2001;285:1996-9. [PMID: 11308437] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Cary P. Gross, MD; Harlan Krumholz, MDAffiliations: Yale School of Medicine; New Haven, CT 06520 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReporting the Recruitment Process in Clinical Trials: Who Are These Patients and How Did They Get There? Cary P. Gross , Raburn Mallory , Asefeh Heiat , and Harlan M. Krumholz Reporting Enrollment in Clinical Trials Scott D. Halpern Reporting Enrollment in Clinical Trials Joseph H. Friedman Reporting Enrollment in Clinical Trials Gregory A. Abel Metrics 17 December 2002Volume 137, Issue 12Page: 1008KeywordsClinical trial reportingDatabasesRandomized trials ePublished: 17 December 2002 Issue Published: 17 December 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A double-blind, randomized comparison of anistreplase and alteplase in acute myocardial infarction: Coronary patency results from the team-3 study
Authors: Jeffrey L. Anderson, Sherman G. Sorensen, Labros Karagounis, Kevin F. Browne, Prediman K. Shah, Douglas C. Morris, Dan J. Fintel, Hiltrud S. Mueller, Allan M. Ross
Journal: Journal of the American College of Cardiology (1991)
Transplantation of pancreas for insulin dependent diabetes.
Authors: R Y Calne
Journal: BMJ (1983)

<h3>Summary</h3> Protein homeostasis involves regulation of the concentrations of unfolded states of globular proteins. Dysregulation can cause phase separation leading to protein-rich deposits. Here, we uncover the sequence-grammar that influences the triad of folding, binding, and phase equilibria of unfolded proteins in cells. We find that the interactions that drive deposit formation of ALS-associated superoxide dismutase 1 mutations are akin to those that drive phase separation and deposit formation in variants of a model protein, barnase. We examined a set of barnase variants to uncover the molecular interactions that drive phase separation of unfolded proteins and formation of unfolded protein deposits (UPODs). The formation of UPODs requires protein destabilization, to increase the concentration of unfolded states, and a requisite sequence grammar to enable cohesive interactions among unfolded proteins. We further find that molecular chaperones, Hsp40 and Hsp70, destabilize UPODs by binding preferentially to and processing unfolded proteins in the dilute phase. <h3>Highlights</h3> Unfolded states of globular proteins undergo aggregation-mediated phase separation to form unfolded protein deposits (UPODs) in cells. The threshold concentration of unfolded proteins required to drive phase separation is governed by a combination of protein stability and the requisite grammar of cohesive motifs known as stickers that provide cohesive intermolecular interactions. The sequence grammar that contributes to phase separation of unfolded proteins shares features with those of proteins that drive the formation of functional biomolecular condensates. Molecular chaperones regulate the concentrations of free unfolded proteins in cells by binding preferentially to unfolded states in dilute phases thereby destabilizing UPOD formation mainly via binding-mediated polyphasic linkage.