tbuckley/cabot-search huggingface dataset:
ON THE URTICARIAL REACTION AND ITS PHYSIOLOGICAL MEANING*
Authors: R. T. GRANT
Journal: British Journal of Dermatology (1926)

Journal Article ON THE URTICARIAL REACTION AND ITS PHYSIOLOGICAL MEANING Get access R. T. GRANT, M.D. R. T. GRANT, M.D. University College Hospital Medical School Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 38, Issue 11, 1 November 1926, Pages 425–430, https://doi.org/10.1111/j.1365-2133.1926.tb09241.x Published: 01 November 1926
Book Review Head and Neck Cancer: A Multidisciplinary Approach Second edition. Edited by Louis B. Harrison, Roy B. Sessions, and Waun Ki Hong. 1077 pp., illustrated. Philadelphia, Lippincott Williams &amp; Wilkins, 2004. $199. 0-7817-3369-3
Authors: Fadlo R. Khuri
Journal: New England Journal of Medicine (2004)
Nephrotic Syndrome with Heart Disease: A Reappraisal
Authors: P. J. Hilton, N. F. Jones, J. R. Tighe
Journal: BMJ (1968)

The evidence that heart failure alone may cause a nephrotic syndrome is inconclusive. Mercurial diuretics, which have also been implicated as a cause of the nephrotic syndrome, had been given in 23 of the 24 well-documented cases.Two cases of heart disease and nephrotic syndrome are described. Glomerular lesions were minimal on light microscopy, but thickening of the glomerular tuft basement membrane and partial fusion of the epithelial cell foot processes were apparent on elecronmicroscopy. The response to prednisone was such as to justify a trial of corticosteroid therapy in such cases despite the presence of cardiac disease.
Passing the Torch at the International Diabetes Federation
Authors: Eugene Barrett, Carolé Mensing, James Horbowicz, Linda Siminerio
Journal: Diabetes Care (2004)

At the triennial International Diabetes Federation (IDF) Congress in Paris this past August, Sir Professor George Alberti completed a distinguished 3-year term as IDF president. George’s contributions to the fight against diabetes have been many during a distinguished career spanning more than three decades. From his work pioneering the use …
Magnetic resonance imaging of acute myocardial infarction: gadolinium diethylenetriamine pentaacetic acid as a marker of reperfusion.
Authors: R M Peshock, C R Malloy, L M Buja, R L Nunnally, R W Parkey, J T Willerson
Journal: Circulation (1986)

We examined the effects of a paramagnetic contrast agent, gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) on magnetic resonance images of acute myocardial infarction with and without reperfusion. Twenty-two dogs underwent occlusion of the left anterior descending coronary artery (LAD). In 10 dogs (group I) the LAD remained occluded for 3 hr and in the other 12 (group II) for 2 hr followed by 1 hr of reperfusion. Gd-DTPA (0.34 mM/kg) was administered to five dogs in group I at 2 hr and 5 min after occlusion and to seven dogs in group II 5 min after reperfusion. At 3 hr after ligation, the hearts were excised and imaged with spin echo and inversion recovery pulse sequences on a 0.35 Tesla magnetic resonance imager. Reperfused hearts given Gd-DTPA demonstrated a significant increase in contrast between normal and reperfused myocardium as compared with nonreperfused hearts and reperfused hearts not given Gd-DTPA. This enhancement was particularly prominent in the inversion recovery images. Studies performed in vivo in two additional dogs demonstrated similar enhancement with reperfusion with Gd-DTPA in gated spin echo images. Contrast-enhanced magnetic resonance imaging allows the detection of reperfusion early in the course of acute infarction.
242 EFFECT OF HIGH-DOSE RIBAVIRIN (RBV), ALINIA (NITAZOXANIDE) AND PEGYLATED INTERFERON (PEGIFN) ALFA-2A IN ATTAINING SUSTAINED VIROLOGIC RESPONSE (SVR) IN TREATMENT OF CHRONIC HEPATITIS C
Authors: P. Basu, K. Rayapudi, N.J. Shah, T. Pacana, N. Krishnaswamy, R. Brown
Journal: Journal of Hepatology (2010)
Glucagon in the treatment of ouabain-induced cardiac arrhythmias in dogs
Authors: K. PRASAD, H. H. DESOUSA
Journal: Cardiovascular Research (1972)

Journal Article Glucagon in the treatment of ouabain-induced cardiac arrhythmias in dogs Get access K. PRASAD, K. PRASAD From the Department of Pharmacology, University of Alberta, Edmonton 7, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar H. H. DESOUSA H. H. DESOUSA From the Department of Pharmacology, University of Alberta, Edmonton 7, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 6, Issue 4, July 1972, Pages 333–343, https://doi.org/10.1093/cvr/6.4.333 Published: 01 July 1972
Changes in Trans Fatty Acid Content
Authors: Paul R. Marantz
Journal: Annals of Internal Medicine (2012)

Letters4 December 2012Changes in Trans Fatty Acid ContentPaul R. Marantz, MD, MPHPaul R. Marantz, MD, MPHFrom Albert Einstein College of Medicine, Bronx, NY 10461.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-11-201212040-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article by Angell and colleagues (1) seeks to explore the effect of New York City's trans fat ban. This kind of analysis of empirical evidence is critically important, and infrequently or seldom conducted, to evaluate the net outcomes of well-meaning public health policy, and the authors (and the New York City Department of Health and Mental Hygiene) should be credited for doing this important work. The study's main finding, that trans fat intake declined after the trans fat ban, is statistically significant but unsurprising: Indeed, if this were not found, it would indicate that the ban ...References1. Angell SY, Cobb LK, Curtis CJ, Konty KJ, Silver LD. Change in trans fatty acid content of fast-food purchases associated with New York City's restaurant regulation: a pre-post study. Ann Intern Med. 2012;157:81-6. [PMID: 22801670] LinkGoogle Scholar2. Lichtenstein AH. New York City trans fat ban: improving the default option when purchasing foods prepared outside of the home [Editorial]. Ann Intern Med. 2012;157:144-5. [PMID: 22801678] LinkGoogle Scholar3. Marantz PR, Bird ED, Alderman MH. A call for higher standards of evidence for dietary guidelines. Am J Prev Med. 2008;34:234-40. [PMID: 18312812] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Albert Einstein College of Medicine, Bronx, NY 10461.Disclosures: Grants/grants pending (money to institution): National Institutes of Health; Payment for lectures including service on speakers bureaus: various; Travel/accommodations/meeting expenses unrelated to activities listed: National Institutes of Health grant reviews. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChange in Trans Fatty Acid Content of Fast-Food Purchases Associated With New York City's Restaurant Regulation Sonia Y. Angell , Laura K. Cobb , Christine J. Curtis , Kevin J. Konty , and Lynn D. Silver Changes in Trans Fatty Acid Content Sonia Y. Angell , Laura K. Cobb , Christine J. Curtis , Kevin J. Konty , and Lynn D. Silver Metrics 4 December 2012Volume 157, Issue 11Page: 834KeywordsFatsFatty acidsObesityPopulation statisticsPrevention, policy, and public healthPsychiatry and mental healthPublic policy ePublished: 4 December 2012 Issue Published: 4 December 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis
Authors: Klaus P Machold, Robert Landewé, Josef S Smolen, Tanja A Stamm, Désirée M van der Heijde, Kirsten N Verpoort, Kerstin Brickmann, Janitzia Vázquez-Mellado, Dimitri E Karateev, Ferdinand C Breedveld, Paul Emery, Thomas W J Huizinga
Journal: Annals of the Rheumatic Diseases (2010)

Glucocorticoids (GCs) are often used as early arthritis treatment and it has been suggested that they induce remission or at least delay the development of rheumatoid arthritis (RA) and the need to start disease-modifying antirheumatic drugs (DMARDs).To test the effect of GCs on patients with very early arthritis (symptom duration of <16 weeks) in a randomised controlled trial.Patients received a single intramuscular injection of 120 mg methylprednisolone or placebo (PL) and were followed up for 52 weeks. Primary end point was drug-free clinical remission, both at weeks 12 and 52. Among secondary outcomes were fulfillment of remission criteria at weeks 2, 12 or 52, time course of 'core set variables' and proportion of patients starting DMARDs.17.0% of all analysed subjects (65/383) achieved persistent remission: 17.8% (33/185) of the PL group, 16.2% (32/198) of the patients receiving methylprednisolone (OR=1.13, 95% CI 0.66 to 1.92, p=0.6847). Analyses of secondary end points showed significant clinical benefits of the GC only at week 2. These differences subsequently disappeared. DMARDs were started in 162 patients: 50.3% methylprednisolone and 56.7% PL patients had to start DMARD treatment (OR=0.78, 95% CI 0.49 to 1.22, p=0.30). Significantly more patients with polyarthritis than with oligoarthritis received DMARDs (OR=2.84, 95% CI 1.75 to 4.60, p<0.0001).Neither remission nor development of RA is delayed by GC treatment. Remission is rare in the first year of very early arthritis, occurring in <20% of the patients. Also, the need to start DMARDs was not influenced by GC treatment.
Simplified cholangiography using ioglycamide
Authors: G. J. S. Parkin, H. Herlinger
Journal: Gut (1974)

Intravenous cholangiograms were performed on 100 unselected nonicteric patients using methylglucamine ioglycamide (Biligram). Fifty patients received 10.5 g of contrast medium and 50 received 5.25 g of medium. The contrast medium was injected evenly over five minutes. Side effects were recorded in only 13% of patients and all were mild. Radiographs were taken 10, 30, 60, 90, and 120 minutes after injection and were assessed without the authors being aware of the dose of contrast medium injected.Better statistically significant results were obtained using the higher dose.In patients in whom the gallbladder is present, films taken at 60 minutes and 90 minutes after injection give the maximum available information in 97% of cases. If the gallbladder has not become opacified by 60 minutes, cystic duct obstruction is indicated. In postcholecystectomy patients, films at 30 minutes and 60 minutes after injection give the maximum available information in 95% of cases.
Plasma glucagon and insulin in rat pregnancy. Roles in glucose homeostasis.
Authors: C D Saudek, M Finkowski, R H Knopp
Journal: Journal of Clinical Investigation (1975)

To determine if pancreatic glucoregulatory hormones can be implicated in the glucose fall of pregnancy, we have measured plasma immunoreactive insulin and glucagon (IRI and IRG) in rats. Fed rats in midgestation show a rise in IRI without a corresponding increase in IRG. In late gestation, IRG rises significantly, but only enough to keep pace with a further rise in IRI. On a molar basis, IRI remains the predominant hormone despite a marked fall in blood glucose. After a 48-h fast IRI falls to comparably low levels in pregnant and virgin rats. A small rise in IRG is seen in virgin but not in pregnant rats despite frank hypoglycemia in the latter. Thus, IRG secretion in pregnancy is diminished relative to IRI in the fed state and fails to increase in the fasted state despite the stimulus of a lower glucose in both instances. To evaluate IRG secretory reserve, the IRG response to i.v. alanine was assessed in late gestation. In fed rats a greater IRG increase is seen in pregnancy; after fasting no difference is seen between pregnant and virgin rats. These results preclude an absolute deficiency in glucagon secretion. Pancreas hormone stores were alos measured in an effort to explain the altered secretory state. We find reciprocal changes in IRI and IRG content favoring IRG in midgestation and IRI in late gestation. Thus, pancreas hormone storage is altered in pregnancy but does not account for the changes in hormone secretion. Rather, pregnancy exerts an effect on the islet secretory process itself. Release of IRI is enhanced relative to IRG regardless of the blood sugar level. These observations suggest that in the pregnant rat circulating levels of insulin and glucagon may act to limit hepatic glucose output. Available evidence from the literature supports the concept of restrained glucose production. It is proposed that a lower blood glucose production. It is proposed that a lower blood glucose in rat pregnancy may be a lesser liability teleologically than would be the obligate nitrogen wasting which accompanies gluconeogenesis.
Effects of N-(2-mercaptopropionyl)-glycine on mitochondrial function in ischemic–reperfused heart
Authors: K Tanonaka
Journal: Cardiovascular Research (2003)

Objective: A possible mechanism for N-(2-mercaptopropionyl)-glycine (MPG) underlying the improvement of contractile function and mitochondrial activity of ischemic–reperfused rat hearts was examined. Methods: Isolated, perfused hearts were subjected to 35 min ischemia–60 min reperfusion. At the end of ischemia or reperfusion, myocardial Na+ content and mitochondrial oxygen consumption rate (OCR) were examined. The perfused heart was treated with 0.1–1 mM MPG for 30 min prior to ischemia or for the first 30 min of reperfusion. Results: Ischemia increased myocardial Na+ content (sodium overload) and decreased mitochondrial OCR. The left ventricular developed pressure (LVDP) of the untreated heart recovered to 19.8±3.8% of the preischemic value and the infarct area amounted to 23.3±1.7% of the left ventricle. The thiobarbiturate-reacting substance (TRS) was also increased in the reperfused, but not ischemic, myocardium. Pretreatment of the perfused heart with 0.3–1 mM MPG attenuated the ischemia-induced sodium overload and decrease in the OCR. Pretreatment with the agent also enhanced the postischemic recovery of LVDP, attenuated reperfusion-induced increase in TRS, and reduced the infarct area. Although the postischemic treatment with MPG suppressed the increase in TRS in the reperfused myocardium, a LVDP recovery of reperfused hearts was not observed. Cardiac mitochondria were isolated and examined for the direct effect of MPG on their function. Incubation with either 12.5 mM sodium lactate or 1 μM phenylarsine oxide neither altered the mitochondrial membrane potential nor induced mitochondrial swelling, whereas incubation with a combination of these agents elicited the membrane potential depolarization and swelling. Incubation of mitochondria with 1 mM MPG attenuated these events. Conclusion: These results suggest that both attenuation of sodium overload and preservation of the mitochondrial function may largely contribute to cardioprotection of MPG in the ischemic–reperfused heart.
UNCINARIASIS—REPORT OF A CASE.
Authors: GEORGE H. EVANS
Journal: JAMA (1903)

Medical literature during the past year has been prolific with reports of uncinariasis in the United States, and a consideration of these cases would seem to infer that the nematode causing this malady is indigenous to this country. The uncinaria are found in several of the lower animals, as dogs, sheep and cattle in different parts of this country, and the investigations of Stiles<sup>1</sup>of the cases submitted to him for examination have caused him to base a new species on them, which he has named the<i>Uncinaria americana</i>, the new-world hookworm, in contradistinction to the<i>Uncinaria duodenalis</i>, or old-world worm. The chief mark of distinction lies in the fact that the new species presents the buccal capsule with a dorsal pair of prominent semilunar plates or lips and a ventral pair of slightly developed lips of the same nature, instead of two pair of ventral teeth curved like hooks,
Eight die in outbreak of virus spread from birds
Authors: F. Charatan
Journal: BMJ (1999)

An outbreak of disease in New York City in August, which was originally diagnosed as St Louis encephalitis, has turned out to be West Nile-like virus, a virus never before found in the United States Previous outbreaks have occurred in Uganda, Israel, Romania and south Africa.

The health commissioner for New York state, Dr Antonia Novello, reported last week that 48 laboratory positive cases of West Nile-like virus had been identified. A total of eight people have died during the outbreak, …
Technetium-99m DTPA Renal Transplant Imaging in the Diagnosis of Urinoma
Authors: A K PADHY, P G GOPINATH, S N MEHTA, D C TIWARI, I K DHAWAN
Journal: Clinical Nuclear Medicine (1989)

A Tc-99m DTPA renal dynamic study was performed on a 24-year-old man who was a renal allograft recipient to evaluate and establish the possible cause of slowly deteriorating transplant function three months after transplantation. The study revealed good transplant perfusion and function and moderate hydroureteronephrosis, with evidence of subtotal obstruction to urine outflow near the junction of the upper one-third and lower two-thirds of the transplanted ureter. Subsequent delayed images of the lower abdomen and urinary bladder revealed a large urinoma.
Quantification of cell adhesion using a spinning disc device and application to surface-reactive materials
Authors: Andrés J. García, Paul Ducheyne, David Boettiger
Journal: Biomaterials (1997)

Quantitative analysis of cell adhesion is essential in understanding physiological phenomena and developing biotechnological applications. Electrochemical measurements demonstrated that the transport patterns associated with a spinning disc device approximate the fluid flow and mass transport fields for a disc spinning in an infinite fluid. Therefore, this device applies a linear range of forces to attached cells under uniform and constant chemical conditions at the interface. The application of this apparatus for examining cell adhesion to surface-active materials was illustrated by investigating the attachment of osteoblast-like cells to fibronectin adsorbed onto bioactive and non-reactive glasses for different chemical environments. Cells were seeded on fibronectin-coated substrates for 15 min and then subjected to detachment forces for 10 min. The number of adherent cells decreased non-linearly with applied force and the detachment profile was accurately described by a sigmoidal curve fit, as expected for a cell population with normally distributed adhesion properties.
CD8+ T-cell autoreactivity to an HLA-B27–restricted self-epitope correlates with ankylosing spondylitis
Authors: Maria T. Fiorillo, Monica Maragno, Richard Butler, Maria L. Dupuis, Rosa Sorrentino
Journal: Journal of Clinical Investigation (2000)

HLA-B27 is highly associated with ankylosing spondylitis (AS), but the mechanism is unknown. Among the HLA-B27 alleles, B*2709, which differs by one amino acid from the susceptible B*2705, is not associated with the disease. Here, we analyze the reactivity, in patients with AS and in healthy controls carrying the B*2709 or B*2705 alleles, to an EBV epitope derived from LMP2 (236-244) and to a sequence-related self-peptide from vasoactive intestinal peptide receptor 1 (VIP1R 400-408). We found that both B*2705+ and B*2709+ subjects possess LMP2 236-244–specific, HLA-B27–restricted T cells, whereas only the B*2705+ individuals respond significantly to VIP1R 400-408. These results prompted us to compare, by IFN-γ ELISPOT analysis, the T-cell response to VIP1R 400-408 in patients with AS versus B*2705 healthy controls. The data show that VIP1R 400-408–specific reactivity is a major feature of the patients with AS. These findings show, for the first time to our knowledge, a widespread reactivity in patients with AS against a self-epitope that exhibits some features of a putative “arthritogenic” peptide.
Transplantation of chondrocytes seeded on a hyaluronan derivative (Hyaff®-11) into cartilage defects in rabbits
Authors: Brunella Grigolo, Livia Roseti, Mauro Fiorini, Milena Fini, Gianluca Giavaresi, Nicolò Nicoli Aldini, Roberto Giardino, Andrea Facchini
Journal: Biomaterials (2001)
Clinical Epidemiology: A Basic Science for Clinical Medicine
Authors: Allen F Shaughnessy
Journal: BMJ (2007)

While many were learning to “study a study and test a test” in the early 1980s, another approach was developing in a small blue collar town in Ontario, Canada, at a new medical school. Internists calling themselves clinical epidemiologists (and refusing to define clinical epidemiology) were putting together a series of articles for the Canadian Medical Association Journal called “Clinical Epidemiology Rounds.”

The article series was “prepared for those clinicians who are behind in their reading.” The huge success of this series led to the expansion of the concepts in the book Clinical Epidemiology: A Basic Science for Clinical Medicine. 

The book emphasises formal probabilistic reasoning as a vital aspect …
Methadone: Some Aspects of Its Legal and Illegal Use
Authors: ROBERT S. WEPPNER, RICHARD C. STEPHENS, HAROLD T. CONRAD
Journal: American Journal of Psychiatry (1972)

A sample of 336 patients admitted to the NIMH Clinical Research Center was surveyed to determine how many had had experience with methadone, either legally or illegally. One-third of the addict sample had been in methadone maintenance programs; 43 percent had used methadone "on the street," often using supplies diverted from legitimate programs. The authors tentatively conclude, in view of the "cheating" reported in programs, that methadone is not meeting the clinical expectation that it will block the euphoric effects of other opiates. More importantly, some addicts have indicated that methadone may become a drug of choice.
Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein rab2.
Authors: J M Larkin, B Oswald, M A McNiven
Journal: Journal of Clinical Investigation (1996)

Chronic ethanol consumption induces hepatocellular retention of nascent proteins leading to hepatomegaly. While the molecular mechanisms behind this impairment are undefined, it has been predicted that protein retention results from a disruption of vesicle-mediated secretory processes. Small GTP-binding proteins (rab proteins) have recently been implicated in the regulation of vesicular trafficking in eukaryotic cells. Our objectives were to identify intracellular sites of ethanol-induced protein retention and to determine whether the distribution of secretory rab proteins was altered by ethanol. Transport of hepatic proteins along the secretory pathway in livers from control and ethanol-fed rats was analyzed using subcellular fractionation and immunoprecipitation in the context of in vivo pulse-chase experiments. We show that pre-Golgi and Golgi compartments, as well as secretory vesicles, are sites of ethanol-induced retention of nascent soluble and transmembrane secretory proteins. These results are supported by immunofluorescence localization of hepatic proteins on liver sections. Further, immunoblot analyses of hepatic subcellular fractions from ethanol-damaged livers indicate a dramatic reduction in the association of rab2 with a Golgi compartment as compared with controls. In contrast, rab6 and alpha-mannosidase II, Golgi marker proteins, appear unchanged. These studies provide a detailed analysis of the intracellular site of ethanol-induced protein retention in the hepatocyte and lend novel insight into a potential mechanism behind this impairment. The effects of ethanol exposure on rab proteins and Golgi function are discussed.