Ciprofloxacin for Salmonella Bacteremia in the Acquired Immunodeficiency Syndrome (AIDS)
Authors: Mark A. Jacobson
Journal: Annals of Internal Medicine (1989)

Brief Reports15 June 1989Ciprofloxacin for Salmonella Bacteremia in the Acquired Immunodeficiency Syndrome (AIDS)Mark A. Jacobson, MD, Stephen M. Hahn, MD, Julie L. Gerberding, MD, Lee Belle, PharmD, Merle A. Sande, MDMark A. Jacobson, MDSearch for more papers by this author, Stephen M. Hahn, MDSearch for more papers by this author, Julie L. Gerberding, MDSearch for more papers by this author, Lee Belle, PharmDSearch for more papers by this author, Merle A. Sande, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-12-1027 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecurrence of salmonella bacteremia after appropriate antibiotic therapy has been well described in patients who have the acquired immunodeficiency syndrome (AIDS) (1-3). After antimicrobial therapy, isolates of Salmonella species from blood generally have remained sensitive to ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol (standard therapies for salmonella bacteremia [1, 2]). However, in some cases of AIDS-associated salmonella bacteremia, breakthrough bacteremia has occurred despite appropriate antibiotic therapy (expected serum drug concentrations exceeded minimum inhibitory concentration [MIC] of the drug for the isolate) (2, 4).Ciprofloxacin is an orally bioavailable quinolone antibiotic with a high ratio of steady-state serum concentration to in-vitro MIC forSalmonella...References1. GlaserMorton-KuteBerger JLS. Recurrent Salmonella typhimurium bacteremia associated with the acquired immunodeficiency syndrome. Ann Intern Med. 1985;102:189-93. LinkGoogle Scholar2. JacobsGoldMurrayRobertsArmstrong JJHRD. Salmonella infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1985;102:186-8. LinkGoogle Scholar3. SperberSchleupner SC. Salmonellosis during infection with human immunodeficiency virus. Rev Infect Dis. 1987;9:925-34. CrossrefMedlineGoogle Scholar4. SmithMacherBookman PAM. Salmonella typhimurium enteritis and bacteremia in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;102:207-9. LinkGoogle Scholar5. Keusch G. Antimicrobial therapy for enteric infections and typhoid fever: state of the art. Rev Infect Dis. 1988;10(suppl 1):S199-205. CrossrefMedlineGoogle Scholar6. ConteBarriere JS. Manual of Antibiotics and Infectious Diseases. 6th ed. Philadelphia: Lea & Febiger; 1988:14-7. Google Scholar7. FerreccioMorrisValdivieso CJC. Efficacy of ciprofloxacin in the treatment of chronic typhoid carriers. J Infect Dis. 1988;157:1235-9. CrossrefMedlineGoogle Scholar8. Infectious Disease Branch, Health and Welfare Agency, State of California. Eradicating the typhoid carrier state. Calif Morbid. 1988;31-2. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of California, San Francisco and San Francisco General Hospital, San Francisco, California. For current author addresses, see end of text. 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