tbuckley/cabot-search huggingface dataset:
Measurement of HLA class I expression in ankylosing spondylitis.
Authors: P Creamer, J Edmonds, J Sullivan, S Matthews
Journal: Annals of the Rheumatic Diseases (1992)

The importance of HLA-B27 in the pathogenesis of ankylosing spondylitis is uncertain: current evidence favours a role for the B27 molecule itself. The possibility that quantitative differences in HLA-B27 expression may exist between patients with ankylosing spondylitis, family members, and control subjects positive for B27 was examined using appropriate monoclonal antibodies, flow cytometry, and a 'model lymphocyte' coated with a known number of mouse immunoglobulin binding sites. No differences were found between the groups. HLA-A2, examined for comparison, was expressed in greater amounts than HLA-B27, but each contributed only 10-20% of the total class I antigens. Homozygotes expressed twice the amount of antigen expressed by heterozygotes. Synovial lymphocytes expressed more class I antigens than peripheral lymphocytes.
Abstract 4919: Myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation potentiates human lung cancer cell malignancy .
Authors: Ching-Hsien Chen, Phillip Thai, Reen Wu
Journal: Cancer Research (2013)

Abstract Myristoylated alanine-rich C kinase substrate (MARCKS), a substrate of protein kinase C (PKC), is a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. Phosphorylated MARCKS (p-MARCKS) has been reportedly to promote inflammatory cell migration in several lung diseases. However, the functionality of MARCKS and its related phosphorylation in lung cancer malignancy has not been characterized. This study demonstrated MARCKS expression and elevated p-MARCKS in various lung cancer cell lines with high malignancy, such as CL1-0-F3, CL1-5, PC9, A549 and several tyrosine kinase inhibitor (TKI) resistant cell lines (H1650 and H1975), as compared with normal human bronchial epithelial (NHBE) cells and low metastasis cancer cell line. siRNA knockdown MARCKS expression resulted in an inhibition of cell migration, accompanying with a decrease of Slug expression in these malignant lung cancer cell lines. Treatment with myristoylated 24-amino-acid MARCKS N-terminus sequence (MANS) peptide, but not the control myristoylated random N-terminal sequence (RNS) peptide, suppressed MARCKS phosphorylation and impaired cell migration and wound healing ability in these lung cancer cell lines. Importantly, MANS peptide treatment resulted in a suppression of lamellipodia/filopodia formation and an enhancement of cell-cell contacts with increased E-cadherin expression. These results confirmed a crucial role for MARCKS, specifically its phosphorylation, in potentiating lung cancer cell migration and malignancy. This study has also suggested a potential usage of MANS or the MARCKS-related peptides in the treatment of lung cancer metastasis. Citation Format: Ching-Hsien Chen, Phillip Thai, Reen Wu. Myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation potentiates human lung cancer cell malignancy . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4919. doi:10.1158/1538-7445.AM2013-4919
The Tricardiograph: A Rapid Screening Method for Cardiac Disease
Authors: J. LEONARD BRANDT, WILLIAM DOCK, ROBERT LANDSMAN, CHARLES PASSANNANTE
Journal: Circulation (1952)

To take slit kymograms of the left hemithorax on 6½ by 8½ inch film, a carrier was designed which can be fitted to the arms of a fluoroscope, replacing the screen. On the lateral and cephalad corner, six seconds of galvanometer trace are recorded, the slit kymograph being exposed during the interval from 3.0 to 4.5 seconds. With two galvanometers, the electrocardiogram and ballistocardiogram can be inscribed, thus timing the motions of the heart border, and permitting correlation of ballistic phenomena with ventricular ejection. This device also has promise as a screening method for detecting cardiac disease.
Phase I Trial Of Fluorouracil Modulation by N-Phosphonacety-L-aspartate and 6-Methylmercaptopurine Riboside: Optimization of 6-Methylmercaptopurine Riboside Dose and Schedule Through Biochemical Analysis of Sequential Tumor Biopsy Specimens
Authors: Peter J. O'Dwyer, GaryR. Hudes, Joseph Colofiore, Judy Walczak, John Hoffman, Frank P. LaCreta, Robert L. Comis, Daniel S. Martin, Robert F. Ozols
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Phase I Trial Of Fluorouracil Modulation by N-Phosphonacety-L-aspartate and 6-Methylmercaptopurine Riboside: Optimization of 6-Methylmercaptopurine Riboside Dose and Schedule Through Biochemical Analysis of Sequential Tumor Biopsy Specimens Get access Peter J. O'Dwyer, Peter J. O'Dwyer Search for other works by this author on: Oxford Academic PubMed Google Scholar GaryR. Hudes, GaryR. Hudes Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph Colofiore, Joseph Colofiore Search for other works by this author on: Oxford Academic PubMed Google Scholar Judy Walczak, Judy Walczak Search for other works by this author on: Oxford Academic PubMed Google Scholar John Hoffman, John Hoffman Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank P. LaCreta, Frank P. LaCreta Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert L. Comis, Robert L. Comis Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel S. Martin, Daniel S. Martin Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert F. Ozols Robert F. Ozols Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 17, 4 September 1991, Pages 1235–1240, https://doi.org/10.1093/jnci/83.17.1235 Published: 04 September 1991 Article history Received: 24 January 1990 Revision received: 16 May 1991 Accepted: 03 June 1991 Published: 04 September 1991
Keeping Eponyms in the Family
Authors: Samuel Vee
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Your recent editorial on halflife of eponyms has set our chordae tendineae atremble. We eponym buffs feel that the extinction of eponymic names would constitute a serious break with medical history as well as a grave injustice to the great physicians whom they immortalize. Should eponyms vanish because the original disease entity which they designated has proved to be a conglomerate of disease? Our answer is no. Instead of discarding an eponym, let us keep it in the family. Surely, every discoverer who graciously bestowed his name on a disease possesses family—a wife, a child, or a mother-in-law who can readily share the eponymic honors by donating first names to new disease offshoots of the family name. Rather than do away with Borgiani poisoning syndrome because it represents two diseases we could call them "Cesare Borgiani" and "Lucrezia Borgiani" syndromes. Similarly, the "Sweeter Syndrome" could be split
Influenza in the West of Scotland, 1966
Authors: J. C. Taylor, C. A. C. Ross, E. J. Stott
Journal: BMJ (1967)

Postpartum Anaemia-Metz et al.BOURNAL considerable variation in individual levels within the groups, and the observed differences in the mean values are not statisti- cally significant.The results of the present study do not suggest any consistent effect of T.D.I.Imferon therapy on vitamin B12 nutrition.Though most of the subjects in the present study showed evidence of folate deficiency, no major reaction to T.D.I.Imferon therapy was encountered in a total of 81 infusions.This finding does not substantiate the suggestion that major reactions may be related to folate deficiency (Lane and Scott, 1965).Thrombophlebitis at the site of infusion occurred in five patients ; it was not related to the use of 5 % dextrose water as diluent for the Imferon, as only normal saline was used.The slow rate of infusion may possibly have been a factor in producing thrombophlebitis. SummaryIron-dextran by the total dose infusion technique was administered to 81 postpartum anaemic subjects with diminished marrow iron stores.Tests of iron, folate, and vitamin Bl. nutrition were carried out before therapy and repeated six weeks later.Iron-dextran therapy was regarded as satisfactory in that anaemia was corrected and tests of iron nutrition returned to normal.In untreated control subjects anaemia was often spontaneously corrected, but this was accompanied by deteriora- tion in iron nutrition.Iron-dextran therapy retarded the improvement in tests of folate nutrition after confinement which occurred in untreated subjects.This substantiates the recommendation that folic acid be administered routinely to patients receiving Imferon therapy for anaemia associated with pregnancy.No consistent effect of iron-dextran therapy on vitamin B12 nutrition could be shown.
Predictors of Cancer-specific Mortality After Disease Recurrence in Patients with Squamous Cell Carcinoma of the Penis
Authors: Malte Rieken, Rosa S. Djajadiningrat, Luis A. Kluth, Ricardo L. Favaretto, Evanguelos Xylinas, Gustavo C. Guimaraes, Fernando A. Soares, Matthew Kent, Daniel D. Sjoberg, Simon Horenblas, Shahrokh F. Shariat
Journal: European Urology (2014)
Cholelithiasis in Jamaican patients with homozygous sickle cell disease
Authors: Iain W. McCall, Patricia Desai, Beryl E. Serjeant, Graham R. Serjeant
Journal: American Journal of Hematology (1977)

Abstract The prevalence of cholelithiasis in Jamaican adults with SS disease was studied by plain abdominal radiograph in 206 patients and by oral cholecystogram in 126 (61%) of these patients. Gallstones were found in 57 (28%) of patients, were more common in females than males, and increased with age and hemolytic rate. The majority of gallstones were visible on the plain abdominal radiograph, only 17% of patients with gallstones having only radiolucent stones. Nonfunctioning oral cholecystograms were common (10%) in agreement with observations by previous workers. Gallstones were noted in the common bile duct in 2 patients. In general there was no clear relationship between the presence of cholelithiasis and clinical symptomatology. Complications, such as pancreatitis and malignant change in the gall bladder, recognized to be associated with cholelithiasis in the general population, have not been clearly related to cholelithiasis in SS disease. More information is needed before a logical policy can be evolved for surgical intervention in cholelithiasis in SS disease.
Dog Bite Wounds
Authors: Michael Callaham
Journal: JAMA (1980)

Dog bite wounds are a common problem with an infection rate only slightly higher than that for lacerations in general. Wounds may be sutured after debridement and thorough irrigation, unless they are located on the hand, where infection is common. Infection is caused by a variety of organisms. A penicillinase-resistant penicillin or cephalexin monohydrate is the drug of choice; studies suggest prophylactic antibiotic therapy may be useful, especially in high-risk wounds.
Innate immune sensing of a growing tumor in vivo occurs via the host sting pathway and involves mitochondrial DNA transfer from cancer cells to DCs
Authors: Seng-Ryong Woo, Michael Leung, Michael Furdyna, Thomas F Gajewski
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Spontaneous T cell responses against tumors occur frequently. However, the mechanisms by which innate immune responses become induced in response to cancer, and how they can bridge to T cell priming against tumor antigens, have been poorly understood. We recently showed that CD11c
Dietary <scp>l</scp> -Arginine Reduces the Progression of Atherosclerosis in Cholesterol-Fed Rabbits
Authors: Rainer H. Böger, Stefanie M. Bode-Böger, Ralf P. Brandes, Laddaval Phivthong-ngam, Michael Böhme, Reinhold Nafe, Andreas Mügge, Jürgen C. Frölich
Journal: Circulation (1997)

Background We investigated whether l -arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects. Methods and Results Rabbits were fed 1% cholesterol for 4 weeks and 0.5% cholesterol for an additional 12 weeks. Two groups of cholesterol-fed rabbits were treated with l -arginine (2.0% in drinking water) or lovastatin (10 mg/d) during weeks 5 through 16. Systemic nitric oxide (NO) formation was assessed as the urinary excretion rates of nitrate and cGMP in weekly intervals. Cholesterol feeding progressively reduced urinary nitrate excretion to ≈40% of baseline ( P &lt;.05) and increased plasma concentrations of asymmetrical dimethylarginine (ADMA), an endogenous NO synthesis inhibitor. Dietary l -arginine reversed the reduction in plasma l -arginine/ADMA ratio and partly restored urinary excretion of nitrate and cGMP (each P &lt;.05 vs cholesterol) but did not change plasma cholesterol levels. l -Arginine completely blocked the progression of carotid intimal plaques, reduced aortic intimal thickening, and preserved endothelium-dependent vasodilator function. Lovastatin treatment reduced plasma cholesterol by 32% but did not improve urinary nitrate or cGMP excretion or endothelium-dependent vasodilation. Lovastatin had a weaker inhibitory effect on carotid plaque formation and aortic intimal thickening than l -arginine. l -Arginine inhibited but lovastatin potentiated superoxide radical generation in the atherosclerotic vascular wall. Conclusions Dietary l -arginine improves NO-dependent vasodilator function in cholesterol-fed rabbits and completely blocks the progression of plaques via restoration of NO synthase substrate availability and reduction of vascular oxidative stress. Lovastatin treatment has a weaker inhibitory effect on the progression of atherosclerosis and no effect on vascular NO elaboration, which may be due to its stimulatory effect on vascular superoxide radical generation.
Effect of a telemonitoring‐facilitated collaboration between general practitioner and heart failure clinic on mortality and rehospitalization rates in severe heart failure: the TEMA‐HF 1 (TElemonitoring in the MAnagement of Heart Failure) study
Authors: Paul Dendale, Gilles De Keulenaer, Pierre Troisfontaines, Caroline Weytjens, Wilfried Mullens, Ivan Elegeert, Bavo Ector, Marita Houbrechts, Koen Willekens, Dominique Hansen
Journal: European Journal of Heart Failure (2011)
Immunologic responses of graft recipients to antilymphocyte globulin: effect of prior treatment with aggregate-free gamma globulin
Authors: Marc E. Weksler, Geoffrey Bull, Gabriel H. Schwartz, Kurt H. Stenzel, Albert L. Rubin
Journal: Journal of Clinical Investigation (1970)

The immunologic response of graft recipients to antilymphocyte globulin has been studied. The clearance from the serum of (125)I-labeled antilymphocyte globulin was studied in 15 graft recipients previously treated with antilymphocyte globulin and in 4 control patients not previously treated with antilymphocyte globulin. The mean serum half-life of antilymphocyte globulin was 7.2 days in control patients, 3.8 days in 13 renal graft recipients, and 22 hr in 2 heart graft recipients. All but one of the antilymphocyte globulin-treated patients had rapid clearance. Patients treated with equine antilymphocyte globulin had rapid clearance of rabbit and goat antilymphocyte globulin as well as horse antilymphocyte globulin. All patients with rapid clearance of antilymphocyte globulin had circulating antibodies to xenogeneic gamma globulin. Two patients with rapid clearance of antilymphocyte globulin had circulating complexes of antilymphocyte globulin. Five renal graft recipients were treated with aggregate-free equine gamma globulin before antilymphocyte globulin therapy in an attempt to induce tolerance to xenogeneic gamma globulin. In these five patients neither rapid clearance of antilymphocyte globulin nor significant titers of circulating antibody to xenogeneic gamma globulin developed. The induction of tolerance to xenogenic gamma globulin may benefit patients treated with antilymphocyte globulin.
Sudden Cardiac Death and Individual Characteristics in Tecumseh, Michigan—A Prospective Study.
Authors: Benjamin N. Chiang
Journal: Annals of Internal Medicine (1969)

s1 May 1969Sudden Cardiac Death and Individual Characteristics in Tecumseh, Michigan—A Prospective Study.Benjamin N. Chiang, M.D., Lawrence V. Perlman, M.D., P. Mary Fulton, M.R.C.P. (Edin.), Leon D. Ostrander Jr., M.D., F.A.C.P., Frederick H. Epstein, M.D.Benjamin N. Chiang, M.D.Search for more papers by this author, Lawrence V. Perlman, M.D.Search for more papers by this author, P. Mary Fulton, M.R.C.P. (Edin.)Search for more papers by this author, Leon D. Ostrander Jr., M.D., F.A.C.P.Search for more papers by this author, Frederick H. Epstein, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1074_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn spite of recent advances an intensive coronary care a significant proportion of individuals with acute coronary occlusion die suddenly outside of hospital. There is, therefore, a need to identify such individuals in advance in order to protect them, if possible, from this catastrophic event. In Tecumseh, Mich., during a 6-year period (1959 to 1965) 43 of 125 (34.4%) coronary deaths occurred suddenly outside of hospital. Of the 43 individuals in this group, 29 were men (67.4%) and 28 were over age 60 (65.1%). Significantly higher blood pressure, abnormal glucose tolerance, and relative weight were found in this group as... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Benjamin N. Chiang, M.D.; Lawrence V. Perlman, M.D.; P. Mary Fulton, M.R.C.P. (Edin.); Leon D. OstranderJr., M.D., F.A.C.P.; Frederick H. Epstein, M.D.Affiliations: Ann Arbor, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1074-1075KeywordsBlood pressureGlucose toleranceProspective studiesSudden cardiac death ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance are potential risk factors for diabetic retinopathy
Authors: Kuppan Kaviarasan, Mohanlal Jithu, Mohammad Arif Mulla, Tarun Sharma, Shanmuganathan Sivasankar, Undurti Narasimha Das, Narayanasamy Angayarkanni
Journal: Metabolism (2015)
The relationship between serotonin 2A receptor gene polymorphisms and serotonin induced platelet aggregation
Authors: Masakatsu Shimizu, Hozuka Akita, Nobuyuki Shiga, Eiji Takai, Chikao Iwai, Yoshitomo Miyamoto, Yukie Jyoukei, Shunichi Kumagai, Masayoshi Hashimoto, Mitsuhiro Yokoyama
Journal: Journal of the American College of Cardiology (2002)
Doxycycline's Effect on Ocular Angiogenesis: An In Vivo Analysis
Authors: Constance A. Cox, Juan Amaral, Rita Salloum, Liliana Guedez, Ted W. Reid, Cindy Jaworski, Moly John-Aryankalayil, Ken A. Freedman, Mercedes M. Campos, Alfredo Martinez, Susan P. Becerra, Deborah A. Carper
Journal: Ophthalmology (2010)
Infant HIV-1 Vaccines
Authors: Genevieve G. Fouda, Coleen K. Cunningham, Sallie R. Permar
Journal: JAMA (2015)

Despite the success of maternal antiretroviral therapy (ART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1), more than 200 000children continue to acquireHIV-1 annually. Infants account for roughly 10% of new HIV-1 infections globally despite making up less than 2%of the world’s population. Moreover, the decline in infant HIV-1 acquisition with implementation of wide-scale maternal-infant ART prophylaxis has not been as steep as predicted, and efforts will not meet the World Health Organization goal to eliminate mother-to-child transmission by 2015. This slow decline in infant HIV-1 infections is partly due to suboptimal coverage at each step of the ART “prevention cascade” (Figure). Yet even if the goal of 90% ART coverage can be achieved, it is estimated that 138 000 infants will still become infected withHIV-1 annually1 because of several situations in which maternal ART prophylaxis is ineffective, including maternal late presentation for care, nonadherence, and acute maternal infection during breastfeeding. In low- and middle-income countries, only half of pregnant women attend therecommended4prenatal visits. Late initiation of ART results in high rates of mother-to-child transmission, with one South African study reporting a tripling of transmission rates in pregnant women who received less than 4 weeks of ART prior to delivery compared with women who received 16 to 32 weeks of treatment.2 Furthermore, a high number of women disengage from care after childbirth (Figure), leaving infants vulnerable to HIV-1 infection. Also of great concern is the increasing incidence ofHIV-1 infection in young women; an estimated 620 000 women aged 15 to 49 years from areas of high HIV-1 prevalence acquired HIV-1 in 2013. Acute HIV-1 infection among mothers accounts for up to 34%of mother-to-child transmission3 and will not be curbed by maternal ART-based strategies. Because of these established gaps in the prevention of mother-to-child transmission, there is a critical need to develop safe, feasible supplemental strategies to be used with the current ART-based strategies, such as a universal infant HIV-1 vaccine.



Figure

Maternal ART Coverage Goal and Currently Achieved ART Coverage in PMTCT High-Burden Countries
Letter from Amsterdam: Flood or pestilence
Authors: R. Hull
Journal: BMJ (1987)

Helping or counselling?Nursing staff in particular can be of great help in advising bereaved and bewildered relatives on the procedures for registration of death, cremation certificates, and finding a suitable undertaker.The hospital chaplain may take on these duties and may be able to put relatives in touch with members of their own religion or community when no relatives are easily accessible.In discussions with some of the (male) leaders of the Hindu, Sikh, and Islamic communities I have not received the impression that there is a need for bereavement counsellors.It is difficult to obtain the women's viewpoint on this as traditionally, and often for linguistic reasons, the man speaks for his wife.It is, however, often acceptable for another woman to talk to a bereaved mother.The Stillbirth and Neonatal Death Society has often been of help to bereaved Asian families, in spite of the linguistic and cultural differences; its address is Argyle House, 29-31 Euston Road, London NWI 2SD.