Lymphoma, Hypercalcemia, and Serum Calcitriol Levels
Authors: CHIKASHI KITOH
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 July 1985Lymphoma, Hypercalcemia, and Serum Calcitriol LevelsCHIKASHI KITOH, M.D.CHIKASHI KITOH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-1-152 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The clinical observation by Breslau and colleagues (1) appears to be significant in suggesting a new mechanism for lymphoma-associated hypercalcemia. However, I have some questions about their conclusion.I have no clinical data with which to conclude that their three patients with lymphoma each have an unrelated elevation in serum calcitriol concentrations. I wonder whether the hypercalcemia can be explained only by the high levels of serum calcitriol. Even now, there is controversy on the specific mechanisms responsible for cancer-associated hypercalcemia (2). The relation between concentrations of serum calcium and calcitriol levels does not mean that the...References1. BRESLAUMCGUIREZERWEKHFRENKELPAK NJJEC. Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma. Ann Intern Med. 1984;100:1-7. LinkGoogle Scholar2. GOTTLEIBRUDESHARPSINGER SRCF. Humoral hypercalcemia of malignancy: a syndrome in search of a hormone. Am J Med. 1982;73:751-5. CrossrefMedlineGoogle Scholar3. BROADUSHORSTLANGLITTLEDIKERASMUSSEN ARREH. The importance of circulating 1,25-dihydroxyvitamin D in the pathogenesis of hypercalciuria and renal-stone formation in primary hyperparathyroidism. N Engl J Med. 1980;302:421-6. CrossrefMedlineGoogle Scholar1. BRESLAUMCGUIREZERWEKHFRENKELPAK NJJEC. Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma. Ann Intern Med. 1984;100:1-7. LinkGoogle Scholar2. ROSENTHALINSOGNAGODSALLSMALDONEWALDRONSTEWART NKJLJA. Elevations in circulating 1,25-dihydroxyvitamin D in three patients with lymphoma-associated hypercalcemia. J Clin Endocrinol Metab. 1985;60:29-33. CrossrefMedlineGoogle Scholar3. NEEDLECHANDRA MB. Hypercalcemia, Hodgkin's disease, and calcitriol. Ann Intern Med. 1984;100:916. LinkGoogle Scholar4. BRESLAUZERWEKHNICARPAK NJMC. Effects of short-term glucocorticoid administration in primary hyperparathyroidism: comparison to sarcoidosis. J Clin Endocrinol Metab. 1982;54:824-30. CrossrefMedlineGoogle Scholar5. MUNDYLUBENRAISZOPPENHEIMBUELL GRLJD. Bone resorbing activity in supernatants from lymphoid cell lines. N Engl J Med. 1974;290:867-71. CrossrefMedlineGoogle Scholar6. MASONFRANKELCHANLISSNERPOSEN RTYDS. Vitamin D conversion by sarcoid lymph node homogenate. Ann Intern Med. 1984;100:59-61. LinkGoogle Scholar7. ADAMSSINGERGACAD JFM. Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis. J Clin Endocrinol Metab. 1985;60:960-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySynthesis of (1,2,4‐Oxadiazole)palladium( II ) Complexes by [2 + 3] Cycloaddition of Nitrile Oxides to Organonitriles in the Presence of PdCl 2Hypercalcemic crisis 1 July 1985Volume 103, Issue 1Page: 152-153KeywordsAttentionCalcitriolCalciumHypercalcemiaLymphoma Issue Published: 1 July 1985 PDF DownloadLoading ...