tbuckley/cabot-search huggingface dataset:
Lead sources, behaviors, and socioeconomic factors in relation to blood lead of native american and white children: a community-based assessment of a former mining area.
Authors: Lorraine Halinka Malcoe, Robert A Lynch, Michelle Crozier Keger, Valerie J Skaggs
Journal: Environmental Health Perspectives (2002)

Lead poisoning prevention requires knowledge of lead sources and of appropriate residential lead standards. Data are severely lacking on lead sources for Native American children, many of whom live in rural areas. Further, the relation of mining waste to blood lead concentrations (BPbs) of rural children is controversial. In collaboration with the eight tribes of northeastern Oklahoma, we assessed lead sources and their effects on BPbs for rural Native American and White children living in a former mining region. Venous blood lead, residential environmental (soil, dust, paint, water), and caregiver interview (e.g., hand-to-mouth behaviors, socioeconomic conditions) data were obtained from a representative sample of 245 children 1-6 years of age. BPbs ranged from 1 to 24 microg/dL. There were no ethnic differences in BPbs (p= 0.48) nor any patterns of excess lead sources for Native American or White children. Multiple linear regression analyses indicated that mean soil lead, mean floor lead loading, mouthing behaviors, caregivers' education, and residence in former mining towns were all strongly associated with BPbs. Logistic regression results showed mean floor dust lead loading greater than or equal to 10.1 microg/ft(2) (odds ratio [OR], 11.4; 95% confidence interval [CI], 3.5-37.3), and yard soil lead >165.3 mg/kg (OR, 4.1; CI, 1.3-12.4) were independently associated with BPbs greater than or equal to 10 microg/dL. We also found strong interactions between soil lead and poverty (p= 0.005), and dust and soil sources (p= 0.02). Our findings indicate that soil and dust lead derived largely from mining waste pose a health hazard to Native American and White children, and that current residential dust lead standards are insufficient to adequately protect children. Moreover, our finding that poor children are especially vulnerable to lead exposures suggests that residential standards should consider interactions among socioeconomic conditions and lead sources if environmental justice is to be achieved.
Additive effects of dobutamine and amrinone on myocardial contractility and ventricular performance in patients with severe heart failure.
Authors: J Gage, H Rutman, D Lucido, T H LeJemtel
Journal: Circulation (1986)

The effects of amrinone, dobutamine, and a combination of the two drugs on peak positive left ventricular dP/dt and left ventricular performance were evaluated in 11 patients with chronic congestive heart failure. When administered alone, both dobutamine (10.9 micrograms/kg/min) and intravenous amrinone (1.9 mg/kg/min) significantly increased left ventricular dP/dt and performance. When compared with dobutamine alone, the addition of amrinone resulted in further increases in left ventricular dP/dt and cardiac index (to 1319 +/- 419 from 1202 +/- 376 mm Hg/sec, p less than .002, and to 3.56 +/- 0.78 from 3.04 +/- 0.67 liters/min/m2, p less than .01, respectively). The combination also induced a further reduction in left ventricular end-diastolic pressure (to 15.3 +/- 11.3 from 18.2 +/- 10.3 mm Hg, p less than .05) when compared with amrinone alone. The combination of dobutamine and amrinone increased heart rate slightly when compared with either drug alone, but did not further reduce systemic arterial pressure when compared with amrinone alone. The dose-response curve of left ventricular dP/dt and performance during titration of dobutamine with and without the addition of intravenous amrinone was evaluated in seven patients. The addition of amrinone to any dose of dobutamine produced higher cardiac index and lower systemic vascular resistance than dobutamine or amrinone alone. Thus, when compared with dobutamine alone in patients with chronic congestive heart failure, the addition of intravenous amrinone to dobutamine results in an additive improvement in left ventricular performance throughout the dose range.
Failure of Erythromycin Estolate Therapy in In Utero Syphilis
Authors: Mary Ann South, David H. Short, John M. Knox
Journal: JAMA (1964)

ERYTHROMYCIN is the most frequently administered antibiotic for the treatment of syphilis in patients with known penicillin allergy. Studies leading to current recommendations of optimum dosages of this drug in various stages of syphilis have been conducted in the Houston Social Hygiene Clinic, but its use during pregnancy has not yet been adequately evaluated. The observation of one patient in our study, who had a good serologic response to treatment with 15 gm of erythromycin estolate (Ilosone), but bore an infant who died of congenital syphilis, is the subject of this report. <h3>Report of a Case</h3> The mother, 16 years of age, gravida II, para I, in approximately the sixth month of pregnancy, had a perigenital, palmar, and plantar maculopapular rash. The clinical diagnosis, secondary syphilis, was supported by a Venereal Disease Research Laboratories slide test (flocculation test using the Atlantic VDRL's specific antigen) reactive at 64 dilutions. Because of
Child mistreatment remains an ugly problem
Authors: Donald E. Riesenberg
Journal: JAMA (1986)

There may be cause for cautious optimism in connection with the ugly problem of child abuse and neglect. But much clearly remains to be done. Nearly a quarter century ago, the late Henry Kempe, MD, and coauthors awakened the national conscience by coining the phrase "the battered-child syndrome" (<i>JAMA</i>1962;181:17-24 and<i>JAMA</i>[MEDICAL NEWS] 1984;251:2069). Leaders in the fight against child abuse gathered in Chicago recently at the Seventh National Conference on Child Abuse and Neglect to review how far remedial efforts have come—and how much farther they have to go—in the aftermath of Kempe's landmark paper. Some of the conclusions depend on how the data are interpreted. Richard J. Gelles, PhD, professor of sociology and anthropology and dean of the College of Arts and Sciences at the University of Rhode Island, Kingston, and Murray A. Straus, PhD, professor of sociology and director of the Family Violence Research Program, University
Comparison of the effect of beta adrenergic antagonists with different ancillary properties on isolated canine and human coronary arteries
Authors: G. BERKENBOOM, J. FONTAINE, J.-M. DESMET, S. DEGRE
Journal: Cardiovascular Research (1987)

Journal Article Comparison of the effect of beta adrenergic antagonists with different ancillary properties on isolated canine and human coronary arteries Get access GUY BERKENBOOM, GUY BERKENBOOM ** From the Cardiology Department, Erasmus Hospital, Brussels, Belgium Address for correspondence and reprints: Dr Guy Berkenboom, Cardiology Department, Hopital Erasme, 808 route de Lennik, Bruxelles 1070, Belgium. Search for other works by this author on: Oxford Academic PubMed Google Scholar JEANINE FONTAINE, JEANINE FONTAINE † From the Pharmacology Department, Institute of Pharmacy, Free University of Brussels, Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar JEAN-MARIE DESMET, JEAN-MARIE DESMET ** From the Cardiology Department, Erasmus Hospital, Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar SERGE DEGRE SERGE DEGRE ** From the Cardiology Department, Erasmus Hospital, Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 4, April 1987, Pages 299–304, https://doi.org/10.1093/cvr/21.4.299 Published: 01 April 1987 Article history Received: 05 June 1986 Accepted: 26 September 1986 Published: 01 April 1987
Emphysematous Cholecystitis After Endoscopic Wallstent Placement Complicated by Distal Migration of the Stent
Authors: M. Takasaki, S. Morita, T. Horimi, M. Takamatsu, M. Kawakami, Y. Yorimitsu
Journal: Endoscopy (1995)

Endoscopic placement of Wallstents was thought to be a less invasive procedure, and in previous publications serious complications were infrequent. We report here on the case of a 58-year-old man with unresectable pancreatic cancer who developed emphysematous cholecystitis after endoscopic placement of a Wallstent, which was further complicated by distal migration of the stent. A second stent had to be placed into the first to fully bridge the malignant stricture. Three days later, the patient developed cholecystitis and septic complications, and he finally died of septic shock with disseminated intravascular coagulation. This previously unreported complication should be considered if abdominal pain and high fever develop after Wallstent placement.
Expression of LDL Receptor, VLDL Receptor, LDL Receptor–Related Protein, and Scavenger Receptor in Rabbit Atherosclerotic Lesions
Authors: Timo P. Hiltunen, Jukka S. Luoma, Tapio Nikkari, Seppo Ylä-Herttuala
Journal: Circulation (1998)

Background —Atherosclerotic lesions contain foam cells that arise from monocyte-macrophages and smooth muscle cells (SMCs) by excessive uptake of lipoproteins. There are many candidate receptors for the lipid accumulation, such as LDL receptor (LDLR), VLDL receptor (VLDLR), LDL receptor-related protein (LRP), and scavenger receptors (SRs). However, little quantitative information exists on the expression of these receptors in normal and atherosclerotic arteries. Methods and Results —Competitive reverse transcription–polymerase chain reaction and in situ hybridization were used for the studies in New Zealand White (NZW) and Watanabe heritable hyperlipidemic (WHHL) rabbit aortic intima-medias. NZW rabbits were fed a 1% cholesterol diet for 0 (control group), 3, 6, or 14 weeks. LDLR mRNA expression was low in aortic intima-medias of all groups. Of the analyzed receptors, LRP had the highest expression in the control group, and its mRNA was induced threefold in the 14-week group, the aortas of which had extensive lesions. SR expression was low and VLDLR expression moderate in the control group. Both receptors were highly induced during cholesterol feeding (SRs, 3-fold and 270-fold induction; VLDLR, 15-fold and 100-fold induction in the 3-week and 14-week groups, respectively). Comparable results were obtained from WHHL rabbits: high basal LRP mRNA in normal intima-medias; moderate induction of LRP and marked induction of SRs and VLDLR in fatty streaks and fatty plaques. In situ hybridization indicated that LRP and VLDLR were expressed in SMCs and macrophages. VLDLR expression was also observed in endothelial cells. SR expression was detected only in macrophages. Conclusions —SR and VLDLR mRNAs were highly induced in atherosclerotic lesions. VLDLR and LRP may be involved in the formation of both SMC–and macrophage-derived foam cells, whereas SRs play an important role in lipid uptake in macrophages.
GW25-e2275 Mitochondrial tRNA-Thr Gene Mutation in Maternally Inherited Hypertension and the Regulatory Mechanism in Adiponectin Pathway
Authors: Lan yunfeng, Yin Tong, Zhu Qinglei, Yang Jie, Li Zongbin, Liu Yiqi, Gao Jinliao, Wang Xueping, Zhu Chao, Zhao Xiaojing, Li Yang
Journal: Journal of the American College of Cardiology (2014)
Evaluation of the clinical utility of platelet aggregation studies
Authors: Alan T. Remaley, Julia M. Kennedy, Michael Laposata
Journal: American Journal of Hematology (1989)

To determine the diagnostic importance of platelet aggregation studies, we evaluated the clinical utility of these assays by a retrospective review of 188 adult patients initially studied for bleeding abnormalities with platelet aggregation tests at a tertiary care hospital from 1984 to 1987. The primary indications for requesting the tests in our patient population were for the evaluation of a positive bleeding history or abnormal bleeding time (68%), hypercoagulability (17%), thrombocytosis (9%), or a family history of a bleeding disorder (6%). There was a statistically higher incidence of platelet aggregation test abnormalities in patients with highly abnormal bleeding times (40%), in patients with thrombocytosis from myeloproliferative disorders (65%), and in patients with a family history of a bleeding disorder (58%), compared to the other groups studied (16-29%). Of the 64 platelet aggregation tests performed that were abnormal, the following abnormalities were identified: 19 aspirin-like defects (poor response to arachidonate and decreased second wave responses to weak agonists), which were presumably drug-induced, ten myeloproliferative-type disorder defects (abnormal response to epinephrine predominantly) in patients known to have myeloproliferative disease, 34 abnormal patterns not characterized as aspirin or myeloproliferative disorder related, four of which ultimately led to a diagnosis of storage pool disease, and one spontaneous aggregation defect. Our results suggest that platelet aggregation tests rarely lead to the diagnosis of a specific, previously undiagnosed platelet function disorder. Specific recommendations are given for efficient utilization of platelet aggregation tests.
Statins and Cancer-Related Mortality — Let's Work Together
Authors: Neil E. Caporaso
Journal: New England Journal of Medicine (2012)

In this issue of the Journal, Nielsen et al.1 provide data suggesting that statin use in Denmark has caused a substantial decline in all-cause and cancer-related mortality. Collectively, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, are the most commonly prescribed class of drugs worldwide, and after two and a half decades of use, this therapy has been credited with declines in cardiovascular events2 at the cost of some common side effects (myalgia and diabetes) and some that are rare (elevated liver enzyme levels and rhabdomyolysis).3 Previous studies focusing on statins and the incidence of cancer have provided only weak . . .
"THE DIATHERMY TREATMENT OF DEMENTIA PARALYTICA"
Authors: Clarence A. Neymann
Journal: JAMA (1933)

To the Editor:  —InThe Journal, June 3, appeared a paper on this subject by Freeman, Fong and Rosenberg.  I have always emphasized that in most instances deteriorated, demented patients will not go into a remission and will not improve. Early in my work the malarial type of fever curve was abandoned as a model. Long sustained temperatures with a high plateau ranging above 103.5 F. for eight hours and above 105.8 and not exceeding 107 for four hours, have been employed and recommended by us for at least two years. I will return to the rationale of this a little later.  The average number of treatments has not been confined to ten or twelve. On the contrary, I believe that the number of treatments necessary to obtain results in a case of dementia paralytica average about twenty. Most remissions take place after the fifteenth, twenty-fifth and thirty-fifth treatment. I
Interactively human: Sharing time, constructing materiality
Authors: Andreas Roepstorff
Journal: Behavioral and Brain Sciences (2013)

Predictive processing models of cognition are promising an elegant way to unite action, perception, and learning. However, in the current formulations, they are species-unspecific and have very little particularly human about them. I propose to examine how, in this framework, humans can be able to massively interact and to build shared worlds that are both material and symbolic.
Treatment With mANT2 shRNA Enhances Antitumor Therapeutic Effects Induced by MUC1 DNA Vaccination
Authors: Yun Choi, Yong H Jeon, Ji-Young Jang, June-Key Chung, Chul-Woo Kim
Journal: Molecular Therapy (2010)

In this study, we developed a combination therapy (pcDNA3/hMUC1+mANT2 shRNA) to enhance the efficiency of MUC1 DNA vaccination by combining it with mANT2 short hairpin RNA (shRNA) treatment in immunocompetent mice. mANT2 shRNA treatment alone increased the apoptosis of BMF cells (B16F1 murine melanoma cell line coexpressing an MUC1 and Fluc gene) and rendered BMF tumor cells more susceptible to lysis by MUC1-associated CD8+ T cells. Furthermore, combined therapy enhanced MUC1 associated T-cell immune response and antitumor effects, and resulted in a higher cure rate than either treatment alone (pcDNA3/hMUC1 or mANT2 shRNA therapy alone). Human MUC1 (hMUC1)-loaded CD11c+ cells in the draining lymph nodes of BMF-bearing mice treated with the combined treatment were found to be most effective at generating hMUC1-associated CD8+IFNγ+ T cells. Furthermore, the in vitro killing activities of hMUC1-associated cytotoxic T cells (CTLs) in the combined therapy were greater than in the respective monotherapies. Cured animals treated with the combined treatment rejected a rechallenge by BMF cells, but not a rechallenge by B16F1-Fluc cells at 14 days after treatment, and showed MUC1 antigen-associated immune responses. These results suggest that combined therapy enhances antitumor activity, and that it offers an effective antitumor strategy for treating melanoma. In this study, we developed a combination therapy (pcDNA3/hMUC1+mANT2 shRNA) to enhance the efficiency of MUC1 DNA vaccination by combining it with mANT2 short hairpin RNA (shRNA) treatment in immunocompetent mice. mANT2 shRNA treatment alone increased the apoptosis of BMF cells (B16F1 murine melanoma cell line coexpressing an MUC1 and Fluc gene) and rendered BMF tumor cells more susceptible to lysis by MUC1-associated CD8+ T cells. Furthermore, combined therapy enhanced MUC1 associated T-cell immune response and antitumor effects, and resulted in a higher cure rate than either treatment alone (pcDNA3/hMUC1 or mANT2 shRNA therapy alone). Human MUC1 (hMUC1)-loaded CD11c+ cells in the draining lymph nodes of BMF-bearing mice treated with the combined treatment were found to be most effective at generating hMUC1-associated CD8+IFNγ+ T cells. Furthermore, the in vitro killing activities of hMUC1-associated cytotoxic T cells (CTLs) in the combined therapy were greater than in the respective monotherapies. Cured animals treated with the combined treatment rejected a rechallenge by BMF cells, but not a rechallenge by B16F1-Fluc cells at 14 days after treatment, and showed MUC1 antigen-associated immune responses. These results suggest that combined therapy enhances antitumor activity, and that it offers an effective antitumor strategy for treating melanoma.
Cisplatin and Vindesine Combination Chemotherapy for Advanced Carcinoma of the Lung: A Randomized Trial Investigating Two Dosage Schedules
Authors: Richard J. Gralla, Ephraim S. Casper, David P. Kelsen, David W. Braun, Mary E. Dukeman, Nael Martini, Charles W. Young, Robert B. Golbey
Journal: Annals of Internal Medicine (1981)

Eighty-five patients with advanced squamous carcinoma or adenocarcinoma of the lung were randomly assigned to receive vindesine with either high dose (120 mg/m2 of body surface area) or low dose (60 mg/m2) cisplatin. All patients had measurable disease and had not previously received chemotherapy. The response rate was similar with both treatments (43% complete and partial remission rate), but the high dose cisplatin regimen was superior to the low dose in median duration of response (12 versus 5.5 months; p = 0.05) and in median survival for responding patients (21.7 versus 10 months; p = 0.02). Myelosuppression was generally not a treatment problem; peripheral neuropathy and moderate azotemia were the major dose-limiting toxicities. With improved survival and response rates over those reported for conventional regimens, this combination of new agents supports the approach of new drug investigation in patients with lung cancer and the importance of the incorporation of active new agents into initial chemotherapy regimens.
Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction
Authors: Emi Suzuki-Kouyama, Kazufumi Katayama, Fuminori Sakurai, Tomoko Yamaguchi, Shinnosuke Kurachi, Kenji Kawabata, Shinsaku Nakagawa, Hiroyuki Mizuguchi
Journal: Biomaterials (2010)
Assembly of collagen-binding peptide with collagen as a bioactive scaffold for osteogenesis in vitro and in vivo
Authors: Jue-Yeon Lee, Jung-Eun Choo, Young-Suk Choi, Jun-Bum Park, Do-Sik Min, Seung-Jin Lee, Hyung Keun Rhyu, In-Ho Jo, Chong-Pyoung Chung, Yoon-Jeong Park
Journal: Biomaterials (2007)
Transdermal Nitroglycerin Patches in Angina Pectoris
Authors: UDHO THADANI
Journal: Annals of Internal Medicine (1986)

The duration of effect of transdermal nitroglycerin patches was studied in 14 patients with angina pectoris. By titrating the dose to achieve specific circulatory effects, we chose a patch size that produced a consistent fall in systolic blood pressure of 10 mm Hg or greater for each patient (10 cm2 in 7 patients, 20 cm2 in 5, and 40 cm2 in 2; releasing 5, 10, and 20 mg of nitroglycerin per 24 hours, respectively). The effects of these individualized patches were compared with those of placebo patches. Compared with placebo, nitroglycerin patches increased exercise duration to the onset of angina (257 ±72 compared with 383 ±130 seconds, p < 0.0001) and total exercise time (338 ±89 compared with 456 ±119 seconds, p < 0.0001) and decreased ST segment depression (1.0 ±0.5 compared with 0.6 ±0.4 mm, p < 0.05) at 4 hours but not at 24 and 48 hours. We conclude that nitroglycerin patches do not show objective evidence of antianginal or antiischemic effects for 24 hours. Tolerance to the circulatory and antianginal effects probably develops within 24 hours of patch application.
Use of the Quinton/Scribner arteriovenous shunt in management of aplastic anaemias.
Authors: B. T. Williams, J. D. Blainey, P. Dawson-Edwards, D. D. Hilton, K. M. Simpson
Journal: BMJ (1967)

20 bMW~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~e~~~~~~~~~4 .After three to four hours a further estimation of the patient's clotting-time is made.If this is not within an acceptable range, a suble adjustment in dosage is made.5. Further estimations of the patient's dotting-time should prob- ably be made daily, to confirm that the anticoagularr.: effect is being maintained. SummaryA method of continuous intravenous infusion of heparin with a syringe-pUmp is described.By this method very constant and easily controllable prolongation of the patient's whole-blood clotting-times were obtained.Reliability, easy supervision, comfort for the patient, and a small volume of intravenous fluid are advantages of this tech- :iique.A suggested regimen for the control of heparin therapy i given.
Correspondence Between the International Diabetes Federation Criteria for Metabolic Syndrome and Insulin Resistance in a Cohort of Italian Nondiabetic Caucasians
Authors: Giorgio Sesti, Brunella Capaldo, Paolo Cavallo Perin, Stefano Del Prato, Lucia Frittitta, Simona Frontoni, Marta Letizia Hribal, Giulio Marchesini, Giuseppe Paolisso, Pier Marco Piatti, Anna Solini, Enzo Bonora
Journal: Diabetes Care (2007)

In 2005, the International Diabetes Federation (IDF) released a consensus definition of the metabolic syndrome. The definition, intended to provide a feasible predictor of cardiovascular disease and type 2 diabetes, includes elevated waist circumference plus two of the following factors: reduced HDL cholesterol or raised blood pressure, triglycerides, or fasting glucose (1). Insulin resistance is a major pathogenic factor for the metabolic syndrome and may independently contribute to the risk of cardiovascular disease and type 2 diabetes (2). We assessed the diagnostic accuracy of the IDF definition of metabolic syndrome in identifying subjects with insulin resistance, defined as being in the lower quartile of insulin-stimulated glucose disposal ( M clamp) determined by a standardized hyperinsulinemic-euglycemic …