tbuckley/cabot-search huggingface dataset:
Folate Supplementation and the Risk of Masking Vitamin B12 Deficiency-Reply
Authors: Katherine L. Tucker
Journal: JAMA (1997)

In Reply.  —Dr Brantigan raises an important concern from the point of view of individual patients. Although our analysis of data from the Framingham Heart Study does suggest that the benefits of folate fortification at the approved level of 140 μg per 100 g of grain-cereal product outweigh the risks of masking anemia due to vitamin B 12 deficiency, we do not mean to imply that there are no risks. Of 694 subjects with complete data, we found low vitamin B 12 concentrations ( 12 status is indeed an important problem. However, only 2.3% and 0.9% of patients had low hemoglobin or high mean corpuscular volume, respectively, suggesting that anemia is clearly an inadequate screening indicator for vitamin B 12 status in this population. High projected folate intake (>800 μ/d) in combination with both low vitamin B 12 concentration and anemia were not seen
Severe Muscle Spasms After Visualization of a Subarachnoid Catheter
Authors: Alfred Feingold
Journal: JAMA (1970)

Severe muscle spasms followed inadvertent subarachnoid administration of diatrizoate meglumine (Renografin), demonstrating the dangers of using this and similar compounds for visualizing a catheter which may lie in, or communicate with, the subarachnoid space. If radiopaque contrast must be used, as is usually necessary even with catheters sold as radiopaque, it would seem prudent to use an oil-base contrast medium rather than a water-soluble agent.
Association of an HLA-DQ Allele With Clinical Tuberculosis
Authors: Anne E. Goldfeld
Journal: JAMA (1998)

Context.—Although tuberculosis (TB) is the leading worldwide cause of death due to an infectious disease, the extent to which progressive clinical disease is associated with genetic host factors remains undefined.Objective.—To determine the distribution of HLA antigens and the frequency of 2 alleles of the tumor necrosis factor α (TNF-α) gene in unrelated individuals with clinical TB (cases) compared with individuals with no history of clinical TB (controls) in a population with a high prevalence of TB exposure.Design.—A 2-stage, case-control molecular typing study conducted in 1995-1996.Setting.—Three district hospitals in Svay Rieng Province in rural Cambodia.Patients.—A total of 78 patients with clinical TB and 49 controls were included in the first stage and 48 patients with TB and 39 controls from the same area and socioeconomic status were included in the second stage.Main Outcome Measures.—Presence of HLA class I and class II alleles determined by sequence-specific oligonucleotide probe hybridization and presence of 2 TNF-α alleles determined by restriction fragment length polymorphism analysis.Results.—In the first stage, 7 DQB1*0503 alleles were detected among 156 alleles derived from patients with TB, whereas no DQB1*0503 alleles were found among the 98 alleles derived from controls (P=.04). There was no detectable difference in the distribution of the 2 TNF-α alleles in patients with TB compared with controls. In the second stage, we tested for the presence of a single variable, the DQB1*0503 allele, and found 9 DQB1*0503 alleles among 96 alleles derived from patients with TB and no DQB1*0503 alleles among 78 alleles in controls (P=.005).Conclusions.—The HLA-DQB1*0503 allele is significantly associated with susceptibility to TB in Cambodian patients and, to our knowledge, is the first identified gene associated with development of clinical TB.
Cardiac tamponade in juvenile rheumatoid arthritis
Authors: A. J. Richards
Journal: Annals of the Rheumatic Diseases (1978)

Cardiac tamponade in juvenile rheumatoid arthritis Sir, I was interested to read the paper by Majeed and Kvasnicka (1978) on cardiac tamponade in a patient with juvenile rheumatoid arthritis.The final com- ment is that it is difficult to judge the value of local corticosteroid injections after pericardiocentesis, but they quote the paper of Scharf et al. (1976) in which the effect of local corticosteroid was dramatic.The authors have overlooked a recent case report (Richards et al., 1976) of an adult with seropositive nodular rheumatoid arthritis whose pericardial effusion cleared promptly following pericardiocentesis and intrapericardial steroids.Immunological data from that patient supported the concept of local production of immune complexes in the pericardial cavity.Might I suggest that if their patient develops another large pericardial effusion, they give in the first instance local corti- costeroids after pericardiocentesis rather than systemic corticosteroids?
Israel permits ova donation from woman who is not undergoing treatment
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2006)

<h3>Background</h3> Although natural regulatory T cells (nTregs) can suppress osteoclastogenesis, the role of TGF-β-induced CD4+Foxp3+ Tregs (iTregs) in osteoclastogenesis remains unknown. <h3>Objective</h3> To determine the effects of iTregs on osteoclastogenesis in vitro and on bone erosion in vivo in collagen-induced arthritis (CIA). <h3>Methods</h3> Osteoclastogenesis was induced in bone marrow CD11b+ cells with receptor activator of nuclear factor κ B (NF-κB) ligand (RANKL) and macrophage colony stimulating factor. Graded doses of Tregs were added to inhibit osteoclastogenesis. Transwell and antibody blockade experiments were performed to assess the roles for cell contact and soluble cytokines. NF-κB activation was determined by western blot. iTregs or nTregs were adoptively transferred to mice with CIA to assess in vivo effects on disease incidence and bone erosion, the latter determined by CT scanning. <h3>Results</h3> Both nTregs and iTregs greatly suppressed osteoclastogenesis in vitro, but only iTregs sustained this effect when interleukin-6 was present. iTregs, but not nTregs, significantly suppressed development of CIA. Bone erosions in iTregs-treated mice were diminished compared with untreated mice or nTregs-treated mice. Treatment with iTregs, but not with nTregs, dramatically decreased NF-κB p65/p50 levels in osteoclasts in vitro and p65/50 and RANKL expression by synovial tissues in vivo. <h3>Conclusion</h3> iTregs may be therapeutically beneficial in rheumatoid arthritis and related diseases associated with bone erosions.
A piece of my mind. Livia
Authors: J. Lazar
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geneticists ponder ethical implications of screening
Authors: Beverly Merz
Journal: JAMA (1985)

"This is a fictitious but not an unrealistic scenario. And I think it could be applied to a lot of people at risk for autosomal dominant disorders that may soon be identified by [DNA diagnostic tests]," says Philip Rilley, MD, JD, who spoke at the recent annual meeting of the American Society for Human Genetics in Salt Lake City, Rilley, staff internist at the Eunice Kennedy Shriver Institute in Boston and a practicing attorney, was one of several speakers at a symposium on the ethical implications of the new genetics. At the symposium geneticists, facing the imminent availability of DNA diagnostic tests for a host of inherited disorders (see accompanying article), mulled over the tests' potential uses and abuses in prenatal counselling. They also explored the advantages and disadvantages of genetic screening for adults who may have inherited disorders for which there is no effective therapy. Participants agreed that there
A Prospective Assessment of the Ability of Endoscopic Ultrasound (EUS) to Diagnose, Exclude, or Establish the Severity of Chronic Pancreatitis Found by Endoscopic Retrograde Pancreatography (ERP)
Authors: A. V. Sahai, M. Zimmerman, L. Aabakken, P. R. Tarnasky, J. T. Cunningham, A. van Velse, R. H. Hawes, B. J. Hoffman
Journal: Endoscopy (1998)
Drug-Induced Subacute Cutaneous Lupus Erythematosus—Filling the Gap in Knowledge
Authors: Jeffrey P. Callen
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Making themselves sicke by phantsye
Authors: Elizabeth Wager
Journal: BMJ (2006)

Dr Wedderburne gave mee this Medicall Counsayle. That I should not be sicke before I was sicke, Noteing the puling spirits of some, & generally of Scholars, who doe allwayes phantsy themselves to be sicke, or sickly, & by phantsye & frequent medicines doe make themselves sick indeede.

John Beale writing to Robert Boyle in 1663. Quoted in The curious life of Robert Hooke by Lisa Jardine, Harper Perennial, London, 2003:215.)
Gastroenterologists outline plan for care of their patients
Authors: Lisa Hitchen
Journal: BMJ (2006)

Clinicians in the United Kingdom have drawn up a blueprint for the future care of patients with gastrointestinal conditions.

Cancers of the gastrointestinal tract account for 21% of all cancers and 27% of cancer deaths in the UK, their report shows.

And the burden on society from gastrointestinal conditions is high. The report says that such diseases cost the NHS £1.4bn (€2bn; $2.5bn) in 2001-2 and that the total cost to the economy was £7.2bn.

Eating and drinking too much are contributing to the figures, the …
Gastrointestinal Fiberoptic Endoscopy in Pediatric Patients and Juveniles
Authors: G. Lux, W. Rösch, J. Phillip, P. Frühmorgen
Journal: Endoscopy (1978)

Over a period of 8 years 351 upper gastrointestinal endoscopies and 72 coloscopies were performed in infants, children and juvenile patients. Development of special pediatric instruments provides increasing application even to the youngest patients. Fiberendoscopy is a safe and sensitive diagnostic tool also in the pediatric age group; furthermore the therapeutic possibilities of operative endoscopy can be used without disadvantage.
GB Virus C Infection in Patients with Type II Cryoglobulinemia
Authors: Gianguglielmo Zehender
Journal: Annals of Internal Medicine (1998)

Letters1 May 1998GB Virus C Infection in Patients with Type II CryoglobulinemiaGianguglielmo Zehender, PhD, Massimo Galli, MD, and Giuseppe Monti, MDGianguglielmo Zehender, PhDUniversita di Milano; Milano 20157, ItalyOspedale di Saronno; Saronno 21047, ItalySearch for more papers by this author, Massimo Galli, MDUniversita di Milano; Milano 20157, ItalyOspedale di Saronno; Saronno 21047, ItalySearch for more papers by this author, and Giuseppe Monti, MDUniversita di Milano; Milano 20157, ItalyOspedale di Saronno; Saronno 21047, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-9-199805010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Misiani and colleagues [1] recently reported a high frequency of GB virus C infection [2] in patients with type II mixed cryoglobulinemia. In 1996 we studied the prevalence of plasma hepatitis G virus (HGV) RNA (a different isolate of GB virus C) [3] in 35 patients who were positive for hepatitis C virus (HCV). Nine patients were men and 26 were women; the mean age ±SD was 66.2 ± 9.0 years. Twenty-three patients had type II and 12 had type III mixed cryoglobulinemia. Twenty patients (9 men and 11 women, with a mean age of 58.8 ± ...References1. Misiani R, Mantero G, Bellavita P, Mori L, Vicari O, Marchesi D, et al. GB virus C infection in patients with type II mixed cryoglobulinemia. Ann Intern Med. 1997; 127:891-4. Google Scholar2. Simons JN, Leary TP, Dawson GJ, Pilot-Matias, Muerhoff AS, Schlauder GG, et al. Isolation of novel virus-like sequences associated with human hepatitis. Nat Med. 1995; 1:564-9. Google Scholar3. Linnen J, Wages J Jr, Zhang-Keck ZY, Fry KE, Krawczynski KZ, Alter H, et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science. 1996; 271:505-8. Google Scholar4. Zehender G, De Maddalena C, Bianchi Bosisio A, Gianotto M, Santambrogio S, Moroni M, et al. Prevalence of hepatitis G virus RNA in HIV-1 positive I.V. drug users. Journal of Human Virology. 1998; 1:96-100. Google Scholar Author, Article, and Disclosure InformationAuthors: Gianguglielmo Zehender, PhD; Massimo Galli, MD; Giuseppe Monti, MDAffiliations: Universita di Milano; Milano 20157, ItalyOspedale di Saronno; Saronno 21047, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCRYOGLOBULINEMIAHepatitis C virus but not GB virus C/hepatitis G virus has a role in type II cryoglobulinemiaHepatitis G Virus and HCV Related Extrahepatic Disease 1 May 1998Volume 128, Issue 9Page: 779KeywordsBlood plasmaEpidemiologyGenomicsHIV-1Hepatitis C virusHepatitis G virusInterferonsPathogenesisRNAReverse transcriptase polymerase chain reaction ePublished: 15 August 2000 Issue Published: 1 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Will Altruism Endanger Prevention?
Authors: Rebecca Voelker
Journal: JAMA (1996)

IT'S AN IRONIC twist that could jeopardize the future of public health and prevention. In an era when the bottom line and managed care concepts increasingly drive the provision of medical services, prevention in some quarters still is regarded as a somewhat selfless write-off rather than part of a cohesive business plan. "The evil word is altruism," said Thomas J. Chapel, MBA, technical director of Macro International Inc, an Atlanta, Gabased evaluation research firm. "I'm in the unfortunate position of saying people are bad for being good." Chapel's firm, commissioned by the Centers for Disease Control and Prevention, studied 8 health care organizations primarily in the Midwest and Northeast. The project attempted to pinpoint how and why the organizations provide preventive services and, in some instances, privatized public health functions. "Altruism, 2 to 1, drives what these folks are doing," Chapel said during this year's annual meeting in Dallas, Tex,
TREATMENT OF A CASE OF CHRONIC VAGINITIS WITH PHENYLMERCURIC NITRATE
Authors: Frederic Wade Hitchings
Journal: JAMA (1935)

It is a matter of common knowledge that it may be extremely difficult to cure a leukorrheal condition. In attempting to do so, the first requisite is to determine the cause. This in itself may be no easy task, and success need not necessarily lead to cure. Bacterial infection, the invasion of parasites, and anatomic and even physiologic conditions all have to be considered. Often several factors from different sources act together in what may be a distressing condition for the patient. So-called remedies are numerous and too often are useless. The case reported here seems to be worth putting on record for two reasons. The first is that it resisted all efforts at treatment for five and one-half years. The second is that cure finally was promptly, and apparently permanently, brought about through the use of douches of phenylmercuric nitrate. In the fall of 1928 an unmarried woman in her late thirties
Markers for Transfusion-Transmitted Disease in Different Groups of Blood Donors
Authors: Jane M. Starkey
Journal: JAMA (1989)

THERE is a growing interest in alternatives to homologous transfusion provided by volunteer donors. Autologous transfusions are increasingly in demand and some patients choose their own donors from among family and friends, a practice called<i>recipient-selected transfusions or directed donations</i>. Providing autologous transfusion for selected patients is medically sound. Patients who can safely donate for their own transfusion needs reduce their exposure to infectious disease. In contrast, no role has been established for directed donations in reducing the infectious complications of transfusion. An assessment of the risk of infection is particularly important, bearing in mind that autologous and directed donations, when not used by their intended recipients, are potentially available for the general blood supply. The number of donations available may be considerable, especially as many autologous collections are inappropriately made to cover elective surgery procedures that seldom require blood.<sup>1</sup> The practice of "crossing over" unused directed donor and
Tests of Urinary Excretion of Uric Acid
Authors: STEPHEN M. SELTZER
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 December 1979Tests of Urinary Excretion of Uric AcidSTEPHEN M. SELTZER, M.D., NEIL SMITHLINE, M.D.STEPHEN M. SELTZER, M.D.Search for more papers by this author, NEIL SMITHLINE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-6-925_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As practicing clinicians, we were delighted to see an article promising a simple convenient test to measure uric acid excretion (1). We were dismayed, however, by the authors' failure to compare their test to the standard one (24-h urine uric-acid excretion) and by their unsupported statement that their test is more physiologic than the standard one.The 24-h urine excretion of uric acid is physiologic because it accurately reflects production and is clinically useful because it is a good predictor of renal stone formation (2). The authors do not supply any data as to whether their test...References1. SIMKIN P, HOOVER P, PAXSON C, and WILSON W. Uric acid excretion: quantitative assessment from spot, midmorning serum and urine samples. Ann Intern Med. 1979;91:44-7. LinkGoogle Scholar2. BROADUS A and THIER S. Metabolic basis of renal-stone disease. N Engl J Med. 1979;300:839-45. CrossrefMedlineGoogle Scholar1. SORENSEN L. Role of the intestinal tract in the elimination of uric acid. Arthritis Rheum. 1965;8:694-706. CrossrefMedlineGoogle Scholar2. YÜ T and GUTMAN A. Uric acid nephrolithiasis in gout: predisposing factors. Ann Intern Med. 1967;67:1133-48. LinkGoogle Scholar1. SIMKIN P, HOOVER P, PAXSON C, and WILSON W. Uric acid excretion: quantitative assessment from spot, midmorning serum and urine samples. Ann Intern Med. 1979;91:44-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEPHEN M. SELTZER, M.D.; NEIL SMITHLINE, M.D.Affiliations: 608 Tucson Medical Park; Tucson, AZ 85712 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCarbohydrates 1 December 1979Volume 91, Issue 6Page: 925-927KeywordsExcretionKidney stonesUric acidUrine ePublished: 1 December 2008 Issue Published: 1 December 1979 PDF downloadLoading ...
Chromosomes and causation of human cancer and leukemia. XXXIII. 5q– in a case of acute lymphoblastic leukemia (ALL)
Authors: S. Abe, S. Kohno, I. Kubonishi, J. Minowada, A. A. Sandberg
Journal: American Journal of Hematology (1979)

Abstract The case of a 4‐year‐old boy with ALL, possibly developing subsequent to a lymphoma involving the throacic cavity, which was shown to be of the T‐cell type, is presented. The leukemic cells had a 5q– anomaly, which had previously been described only in cases of refractory anemia and/or AML. The 5q– abnormality was invariably accompanied by a 9p– chromosome in the leukemic cells. The interstitial deletion leading to the 5q– chromosome was shown with banding techniques to be similar to that described previously in myeloproliferative disorders. Some aspects of the 5q– anomaly in ALL and its relation to previous experience with this karyotypic change are discussed.
Reply to Dr. Anders.
Authors: J. M. G. Carter
Journal: JAMA (1897)

Chicago, April 5, 1897. <h3>To the Editor:</h3> —In reply to Dr. Anders' inquiry I can say that the First Methodist Episcopal Church of Waukegan, Ill., which has a membership of 300, has used the individual communion cup for four years. It met with general approbation from the beginning, only two or three members refusing to participate. It is a complete success, as the details have been conveniently arranged. Respectfully,
Reduction of increased polyamine levels in psoriatic lesions by retinoid and PUVA treatments
Authors: JORMA LAUHARANTA, MERJA KOUSA, KIRSTI KAPYAHO, KIRSTI LINNAMAA, KIMMO MUSTAKALLIO
Journal: British Journal of Dermatology (1981)

Treatment with an oral aromatie retinoid (etretinate) and with PUVA significantly reduced the elevated levels of putrescine, spermidine and spermlne in psoriatic lesions. Both treatments also significantly reduced the spermidine/spermine ratio, which is considered to be an indicator of proliferation activity. Although both regimens produced a roughly parallel reduction of epidermal polyamines the initial fall of putrescine was much more rapid in patients receiving retinoid. This may indicate that one of the primary targets of retinoids could be ornithine deearboxylase.
Total paracentesis in cirrhotics with refractory ascites: Albumin vs HES as plasmatic expanders
Authors: C. Méndez, G. Soriano, C. Guarner, A. Tomás, D. Moyano, H. Toro, R. Portorreal, J.M. Rodríguez, F. Vilardell
Journal: Journal of Hepatology (1991)