tbuckley/cabot-search huggingface dataset:
Parallel Stimulation of Glucose and Mg <sup>2+</sup> Accumulation by Insulin in Rat Hearts and Cardiac Ventricular Myocytes
Authors: Andrea M. P. Romani, Veronica D. Matthews, Antonio Scarpa
Journal: Circulation Research (2000)

Abstract —The stimulation of β-adrenoceptors in cardiac cells results in a rapid loss of cellular Mg 2+ . Because insulin physiologically counteracts several of the cellular effects mediated by the activation of β-adrenoceptors and the elevation of cytosolic cAMP levels, we investigated whether insulin administration could prevent Mg 2+ mobilization from rat hearts and ventricular myocytes. Rat hearts were perfused in a retrograde Langendorff system, and the changes in extracellular Mg 2+ were measured by atomic absorbance spectrophotometry. Pretreatment of the hearts with 6 nmol/L insulin completely prevented the Mg 2+ extrusion induced by the β-adrenergic agonist isoproterenol. Furthermore, the administration of insulin per se induced an accumulation of Mg 2+ by the heart. This accumulation was small but detectable in the presence of 25 to 35 μmol/L [Mg 2+ ] o and increased in proportion to [Mg 2+ ] o . Insulin-mediated Mg 2+ accumulation was not observed in hearts perfused with a medium devoid of glucose or with a medium containing the inhibitors of glucose transport, cytochalasin B and phloretin. Insulin-stimulated [ 3 H]2-deoxyglucose accumulation was measured in collagenase-dispersed cardiac ventricular myocytes in the presence of varying levels of [Mg 2+ ] o . Glucose transport was not observed below 25 μmol/L [Mg 2+ ] o , and it also increased in proportion to [Mg 2+ ] o . Taken together, these results indicate the presence of a major uptake of Mg 2+ into cardiac cells that is stimulated by insulin and may require the insulin-induced operation of a glucose transporter. Hence, extracellular and/or intracellular Mg 2+ may modulate glucose transport and/or utilization.
Determinants of frequency domain measures of heart rate variability in the acute and convalescent phases of myocardial infarction
Authors: J. O Valkama, H. V Huikuri, K E J. Airaksinen, M. L Linnaluoto, J. T Takkunen
Journal: Cardiovascular Research (1994)

Objective: Low heart rate variability after acute myocardial infarction is associated with an increased risk of cardiac mortality. The aim of this study was to investigate the determinants of frequency domain measures of heart rate variability in acute myocardial infarction. Methods: Heart rate variability in the frequency domain was compared in 43 patients in the early (0-12 h from the onset of pain) and convalescent (1 week after) phases of myocardial infarction and related to location (22 patients with anterior infarction and 21 patients with inferior infarction) and size of the infarct, occurrence of ventricular ectopic activity, and thrombolytic therapy. Results: In the early phase of infarction all the power spectral components of heart variability were significantly lower in the patients with anterior infarcts than in those with inferior infarcts (p < 0.05 for all), but heart rate variability did not differ significantly between anterior and inferior infarct groups in the convalescent phase. High frequency power of heart rate variability was significantly lower in the convalescent phase than in the early phase in both the anterior and inferior infarction groups (p < 0.05 and p = 0.001, respectively), but other measures of variability did not change significantly. The ejection fraction was correlated with total power (p < 0.05), low frequency power (p < 0.01), and very low frequency power of heart rate variability (p < 0.05), and the low frequency and high frequency power components were significantly lower in the patients with non-sustained ventricular tachycardia than in those without repetitive ventricular activity in the convalescent phase of myocardial infarction (p < 0.05). Thrombolytic therapy had no influence on the measures of heart rate variability. Conclusions: The frequency domain measures of heart rate variability are mostly determined by the location of myocardial infarction in the early phase, whereas a correlation between heart rate variability and left ventricular function and arrhythmic propensity is more obvious in the convalescent phase. Cardiovascular Research 1994;28:1273-1276
DIAGNOSIS OF BREAST CANCER
Authors: Sigismund Peller
Journal: JAMA (1960)

<h3>To the Editor:—</h3> I wish to comment on the article "Validity of Pathological Diagnosis of Breast Cancer" by Linden and others inThe Journal, May 14, page 143. The first point concerns the five-year survival rate of those registered between 1942 and 1948. Of the histologically examined breast cancer patients 48.3% survived, while only 18.9% of those without histological examination survived. The latter group was, according to table 7, in a worse condition, whether the cases were still localized or had regional metastases or distant metastases or were not classified by stage. As the total of patients was about 1,550 and their over-all five-year survival rate 44%, I assume that the survival rates for the two previously mentioned groups of cases were 48.3 ± 1.4 and 18.9 ± 2.7% respectively. There must have been a reason for this statistically high significant difference. What was the criterion according to which a
The Scientific Contributions of Charles Brenton Huggins
Authors: Paul Talalay
Journal: JAMA (1965)

Few men who work on the problem of human disease attain in their lifetime the fullness of accomplishment of which they are capable. There are so many distractions and diversions in professional life, and there is so much hollow applause for triviality, that a person only rarely has the determination and the tenacity of purpose to steer an unwavering course along the path of scientific discovery. As we celebrate the 21st anniversary of the Passano Award, we pay tribute to Charles Brenton Huggins, a uniquely gifted surgeon and investigator who has in full measure throughout his life hewed to the hard and narrow road of research and service to humanity. It is my pleasant honor to relate some of the major facets of the scientific contributions of Dr. Charles Huggins, who has spent his entire academic life at the University of Chicago where he is Director of the Ben May
Comparison of Cytolytic and Proliferative Activities of Human γδ and αβ T Cells From Peripheral Blood Against Various Human Tumor Cell Lines
Authors: Angela S. Ensslin, Bent Formby
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Comparison of Cytolytic and Proliferative Activities of Human γδ and αβ T Cells From Peripheral Blood Against Various Human Tumor Cell Lines Get access Angela S. Ensslin, Angela S. Ensslin Search for other works by this author on: Oxford Academic PubMed Google Scholar Bent Formby Bent Formby Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 21, 6 November 1991, Pages 1564–1569, https://doi.org/10.1093/jnci/83.21.1564 Published: 06 November 1991 Article history Received: 04 February 1991 Revision received: 15 July 1991 Accepted: 19 July 1991 Published: 06 November 1991
Endoscopic ultrasound-guided celiac ganglia neurolysis vs. celiac plexus neurolysis: a randomized multicenter trial
Authors: S. Doi, I. Yasuda, H. Kawakami, T. Hayashi, H. Hisai, A. Irisawa, T. Mukai, A. Katanuma, K. Kubota, T. Ohnishi, S. Ryozawa, K. Hara, T. Itoi, K. Hanada, K. Yamao
Journal: Endoscopy (2013)

<b>Background and study aims: </b>No prospective comparison of endoscopic ultrasonography-guided direct celiac ganglia neurolysis (EUS – CGN) vs. EUS-guided celiac plexus neurolysis (EUS – CPN) has been reported. The aim of the current study was to compare the effectiveness of EUS – CGN and EUS – CPN in providing pain relief from upper abdominal cancer pain in a multicenter randomized controlled trial. <b>Patients and methods: </b>Patients with upper abdominal cancer pain were randomly assigned to treatment using either EUS – CGN or EUS – CPN. Evaluation was performed at Day 7 postoperatively using a pain scale of 0 to 10. Patients for whom pain decreased to ≤ 3 were considered to have a positive response, and those experiencing a decrease in pain to ≤ 1 were considered to be completely responsive. Comparison between the two groups was performed using intention-to-treat analysis. The primary endpoint was the difference in treatment response rates between EUS – CGN and EUS – CPN at postoperative Day 7. Secondary endpoints included differences in complete response rates, pain scores, duration of pain relief, and incidence of adverse effects. <b>Results: </b>A total of 34 patients were assigned to each group. Visualization of ganglia was possible in 30 cases (88 %) in the EUS – CGN group. The positive response rate was significantly higher in the EUS – CGN group (73.5 %) than in the EUS – CPN group (45.5 %; <i>P</i> = 0.026). The complete response rate was also significantly higher in the EUS – CGN group (50.0 %) than in the EUS – CPN group (18.2 %; <i>P</i> = 0.010). There was no difference in adverse events or duration of pain relief between the two groups. <b>Conclusions: </b>EUS – CGN is significantly superior to conventional EUS – CPN in cancer pain relief. <b>Clinical trial registration: </b> <ext-link href="http://www.umin.ac.jp/ctr/index.htm">http://www.umin.ac.jp/ctr/index.htm</ext-link> (ID: UMIN-000002536)
Letter: Should doctors strike again?
Authors: A Short, A S Aldis, R C Cook, D M Jackson, C G Scorer, R S Walker
Journal: BMJ (1976)

between treated and untreated patients in learning behaviour or intellect, and seizure control was significantly improved in the treated group.7A more recent survey of epileptic children in schools showed that those who were receiving phenobarbitone were achieving more educationally and had fewer behaviour problems than others who were not being so treated.8Furthermore, no significant reduction was noted in the Wechsler Intelli- gence Scale for Children when this was administered at least eight years after a con- vulsion with fever to children who had received barbiturates for at least one year before the age of 7 years.9On the other hand, a reduced verbal quotient was significantly related to recurrence of convulsions.9It has been shown that it may not be possible to prevent all recurrences of febrile convulsions by the use of phenobarbitone in apparently "therapeutic" dosage," but significant reduction in the recurrence rate has been achieved in a group of high-risk patients.'2Longer, better-controlled studies must surely be conducted before barbiturates are discarded in favour of less well-tried and possibly more harmful anticonvulsants.
Lupus, hereditary angioneurotic oedema and the risks of danazol treatment
Authors: B. Sassolas, G. Guillet
Journal: British Journal of Dermatology (1991)

Journal Article Lupus, hereditary angioneurotic oedema and the risks of danazol treatment Get access B. Sassolas, B. Sassolas Department of Dermatology, CHU Brest, 29609 Brest Cedex, France Search for other works by this author on: Oxford Academic Google Scholar G. Guillet G. Guillet Department of Dermatology, CHU Brest, 29609 Brest Cedex, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 125, Issue 2, 1 August 1991, Pages 190–191, https://doi.org/10.1111/j.1365-2133.1991.tb06072.x Published: 01 August 1991
Die Seelenstörungen Der Blutdruckkranken. Beiträge zur psychiatrischen Alterspathologie und zu einer "Psychiatrie auf pathophysiologischer Grundlage." By<i>Privatdozent Dr. E. Krapf.</i>(Leipzig und Wien: Franz Deuticke 1936.)
Authors: J. Notkin
Journal: American Journal of Psychiatry (1936)
Increased In-111 Octreotide Uptake due to Paget Disease and a Low Midline Pelvic Kidney
Authors: Leo Ha, Robert Mansberg, Hans Van Der Wall, Louise Emmett, Michael Magee
Journal: Clinical Nuclear Medicine (2009)

An 86-year-old female was referred for investigation of long-standing diarrhea and recent endoscopic ultrasound demonstration of a pancreatic head lesion. In-111 octreotide SPECT CT was performed and demonstrated increased tracer uptake in the midline pelvis and at the left acetabulum/ischium and proximal left femur. Corresponding CT images confirmed the presence of an ectopic left kidney in the pelvis and changes of Paget disease in the left hemi-pelvis and proximal femur.
PHOTOSENSITIVITY BY DEMETHYLCHLORTETRACYCLINE AND SULPHANILAMIDE
Authors: J. D. Stratigos, I. A. Magnus
Journal: British Journal of Dermatology (1968)

SUMMARY. Photosensitization of the skin by demethylchlortetracycline and sulphanilamide has been demonstrated in mice. Demethylchlortetracycline has an action spectrum extending from 350 to 420 nm with a peak at 400 nm; it is most effective in mice when given by the intradermal route, less effective intraperitoneally and without action orally. Sulphanilamide has a photosensitizing action spectrum from 375 to 400 nm, i.e. mostly in the visible spectrum, with less certain activity at 280–300 and 550–600 nm; it is effective intradermally and inactive orally. The majority of the photosensitizing effects of sulphanilamide must be due either to the alteration of its constitution in the skin, or to a metabolic change in the skin itself since sulphanilamide does not absorb visible light. Possible mechanisms are discussed and a speculative hypothesis is proposed that a local disturbance of porphyrin metabolism may be implicated.
Vaccine-Acquired Polio in An Unvaccinated Mother
Authors: H. E. Thelander
Journal: JAMA (1966)

To the Editor:—  The article Vaccine-Acquired Paralytic Poliomyelitis in an Unvaccinated Mother by L. J. Morse, et al ( 197 :1034, 1966) prompts me to report on two infants born of mothers who had received polio vaccine while pregnant.  In the Child Development Center at Children's Hospital, all types of handicapped children are seen, including a great many with birth defects. The two cases herein reported impressed me because the appearance of flaccid paralysis as a major birth defect is unusual.  The first infant was born Oct 26, 1961, and was a full-term baby, birth weight 7 lb 13 oz. This little boy has facial paralysis on the left. His tongue protrudes toward the right. The left eyelid fails to close completely. He has difficulty in swallowing. In addition to these paralytic symptoms he has syndactylism of the right hand, a missing pectoralis major muscle, and a missing nipple on the
Steroids and Disseminated Sclerosis
Authors: F. J. Lichtigfeld
Journal: BMJ (1963)

thought and planning.I suggest a system based on insurance clinics is a feasible and worth-while goal-to improve general practice conditions.It would save the G.P.'s time and save the Government money-a combination, I feel, which makes for a fair chance of accomplish- ment.-Iam, etc.,
Activated protein C inhibits the release of proinflammatory cytokines and chemokines from the monocytic cell line THP-1
Authors: Martina Brueckmann, Hans Martin Weiler, Antje Marx, Volker Liebe, Siegfried Lang, Martin Borggrefe, Guenter Huhle, Karl K. Haase
Journal: Journal of the American College of Cardiology (2003)
The struggle for equity: an examination of surgical services at two NGO hospitals in rural Haiti
Authors: Alexi C Matousek, Stephen R Addington, Rodolphe R Eisenhower Jean-Louis, Jean Hamiltong Pierre, Jacky Fils, Marguerite Hoyler, Sarah B Matousek, Jordan Pyda, Paul E Farmer, Robert Riviello
Journal: The Lancet (2015)
Experience with screening newborns for Duchenne muscular dystrophy in Wales.
Authors: D M Bradley, E P Parsons, A J Clarke
Journal: BMJ (1993)

OBJECTIVES--To assess the acceptability of screening newborn boys for Duchenne muscular dystrophy. DESIGN--Screening is offered on the basis of informed consent in response to an information sheet entitled "A new test for baby boys--Do you want it?" The programme includes a prospective long term evaluation of family responses to early diagnosis and a comparison of their experiences and perceptions with those families who have undergone the later traditional clinical diagnosis. SETTING--All maternity units throughout Wales. Samples obtained through screening programme for phenylketonuria and congenital hypothyroidism. SUBJECTS--Those families whose son had a positive screening test. MAIN OUTCOME MEASURES--Creatine kinase activity. Venous blood test to confirm positive result. Molecular genetic mutation analysis. Muscle biopsy and dystrophin analysis. Qualitative measure of satisfaction among affected families. RESULTS--34,219 Boys have been screened and nine affected families have been identified. Eight families were very positive about the programme. Three chose not to complete the diagnostic process. CONCLUSION--The programme should continue to permit a full evaluation of the issues involved and should serve as a model for other initiatives within the community for genetic disease.
Puncture of the Gallbladder During Percutaneous Transhepatic Cholangiography
Authors: Clement J. DeMasi
Journal: JAMA (1967)

Seven cases of unintentional puncture of the gallbladder occurred during percutaneous transhepatic cholangiography. Adequate visualization of the biliary tree was obtained in each case. Biliary leakage developed in one patient who had complete obstruction due to carcinoma of the pancreas. As more percutaneous transhepatic cholangiography is performed, we may expect more instances of inadvertent puncture of the gallbladder to appear. Suggestions are offered that may help reduce the complications and yet allow the procedure to be performed even in instances where puncture of the gallbladder seems inevitable.
Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells
Authors: P Gamas, S Marchetti, A Puissant, S Grosso, A Jacquel, P Colosetti, J-M Pasquet, F-X Mahon, J-P Cassuto, P Auberger
Journal: Leukemia (2009)
Triangulating phenomenal consciousness
Authors: Patricia Kitcher
Journal: Behavioral and Brain Sciences (1995)

Abstract This commentary offers two criticisms of Block's account of phenomenal consciousness and a brief sketch of a rival account. The negative points are that monitoring consciousness also involves the possession of certain states and that phenomenal consciousness inevitably involves some sort of monitoring. My positive suggestion is that “phenomenal consciousness” may refer to our ability to monitor the rich but preconceptual states that retain perceptual information for complex processing.
ON THE RELATION OF SEX TO THE PROGNOSIS OF EPILEPSY.
Authors: WILLIAM BROWNING
Journal: JAMA (1895)

The purpose of this paper is briefly to call attention to a difference in the sexes as regards chances of recovery from the convulsive habit. This is a matter that has not been absolutely overlooked, though it seems to have received scant attention. Only in Gowers have I so far found any original reference to it, and he simply says that, "the prospect of arrest is slightly better in males than in females." It is unusual for sex to play a very important rôle in those diseases that are common to both male and female. Among epileptics there is no great preponderence of one sex over the other. In my former statistics (to July, 1891)<sup>1</sup>of this disorder there were 84 M. to 66 F. Reynolds found 102 M. to 70 F., but says that "practically, the two sexes appear to be about equally affected." Some later statistics indicate
Anglo-Yugoslav Medical Relations in Peace and War
Authors: Z. Lowenthal
Journal: BMJ (1961)

Although the medical centres of Great Britain, owing to their distance from Yugoslavia,t have influenced Yugo- slavian medicine less than those of neighbouring countries such as Italy, Austria, and Hungary, some traces of contact can be found as far back as the seventeenth and eighteenth centuries.But the first real co-operation dates from the end of the nineteenth century, when assistance began to be given to Yugo- slavia by various British charitable and other organiza- tions, by groups of doctors, and by individuals- assistance which has continued during the first half of this century.The first observations on health conditions prevailing in Yugoslavia can be found in the writings of several British doctors, diplomats, travellers, and visitors, like John Burbury, George Sandys, and others who travelled through Austria, Hungary, Serbia, and Turkey.One of the oldest of these descriptions is that by Edward Browne, F.R.S., published in London in 1673
A Comparative Study of Spatial Vectorcardiograms Obtained with the Equilateral Tetrahedron and a "Corrected" System of Electrode Placement
Authors: J. A. ABILDSKOV, ELDON D. PENCE
Journal: Circulation (1956)

Spatial vectorcardiograms of a group of normal young adults, recorded with two systems of electrode placement, have been studied. Those recorded with the equilateral tetrahedron as the reference system were similar to records previously described and had QRS-loops of two configurations. Those recorded with a method of lead placement designed to reduce the errors inherent in the commonly used reference frames had greater uniformity of form and orientation of both the QRS and T-loops.
Changes in Configuration of the Ventricular Chambers during the Cardiac Cycle
Authors: ROBERT F. RUSHMER, DEAN K. CRYSTAL
Journal: Circulation (1951)

Cinefluorographic angiocardiography has been used to record the sequential changes in the size and shape of the right and left ventricular chambers and the external cardiac silhouette in dogs. Evidence is presented which indicates that (1) the left ventricle is usually filled more rapidly than it is emptied, (2) the diastolic size appears to remain remarkably constant during a major portion of the diastolic period and (3) residual blood remains within the ventricle at the end of systole.
New Directions for the National Health Service Corps
Authors: Martin P. Wasserman
Journal: JAMA (1974)

On Dec 31, 1970, President Nixon signed into law the Emergency Health Personnel Act, which created the National Health Service Corps (NHSC). The intent of the legislation is to improve the delivery of health services to persons living in those communities of the United States where health personnel, facilities, or services are inadequate. The goal of the NHSC is to recruit and place appropriate health professionals in these areas and to assist the communities in developing ongoing, self-sufficient health care delivery systems. The program is administered in the Bureau of Community Health Services of the Health Service Administration, one of six Public Health Service agencies in the Department of Health, Education, and Welfare. Since its inception, the program has been run primarily as a demonstration project with a current budget of approximately $13.4 million. Despite this modest investment, the NHSC has had a powerful impact in those communities designated as
THE BENEFICIAL EFFECTS OF STATIN THERAPY ON EPICARDIAL ADIPOSE TISSUE AND CORONARY PLAQUE VOLUMES WITH VULNERABLE CHARACTERISTICS MEASURED BY COMPUTED TOMOGRAPHY ANGIOGRAPHY
Authors: Naser Ahmadi, Fereshteh Hajsadeghi, Vahid Nabavi, Rohit Arora, Matthew Budoff
Journal: Journal of the American College of Cardiology (2013)
Drug points: Neutropenia caused by intravenous immunoglobulin
Authors: R V Majer, P J Green
Journal: BMJ (1988)

Digoxin is a widely prescribed drug with narrow therapeutic margins, and intoxication is a common complication.We report a case ofsevere generalised chorea, agitation, and emotional disturbance due to digoxin excess.A 63 year old woman with a dissection of the ascending aorta had been treated conservatively for one month with digoxin 250 ig daily, labetalol 100 mg three times a day, dihydralazine 25 mg twice a day,
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I
Authors: Penghua Wang, Alvaro Arjona, Yue Zhang, Hameeda Sultana, Jianfeng Dai, Long Yang, Philippe M LeBlanc, Karine Doiron, Maya Saleh, Erol Fikrig
Journal: Nature Immunology (2010)