Helicobacter pylori Eradication in Gastric: Mucosa-Associated Lymphoid: Tissue Lymphomas
Authors: Emanuele Zucca
Journal: Annals of Internal Medicine (1996)

Letters15 January 1996Helicobacter pylori Eradication in Gastric: Mucosa-Associated Lymphoid: Tissue LymphomasEmanuele Zucca, MD, Enrico Roggero, MD, and Franco Cavalli, MDEmanuele Zucca, MDOspedale San Giovanni; 6500 Bellinzona; SwitzerlandSearch for more papers by this author, Enrico Roggero, MDOspedale San Giovanni; 6500 Bellinzona; SwitzerlandSearch for more papers by this author, and Franco Cavalli, MDOspedale San Giovanni; 6500 Bellinzona; SwitzerlandSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-2-199601150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We generally agree with Montalban and associates' comments. We have now treated more than 40 patients with antibiotics, confirming in more cases that histologic regression of localized low-grade MALT lymphoma can be achieved in more than 60% of patients after eradication of Helicobacter pylori[1].Histologic assessment remains, in our opinion, the pivotal method for treatment evaluation, given that molecular analysis is not yet widely available; moreover, the clinical significance of molecular remission remains controversial in other low-grade lymphomas (for example, Bcl-2 rearrangement monitoring in follicular lymphoma) [2]. However, we have done molecular studies (PCR detection of IgH gene ...References1. Pinotti G, Zucca E, Roggero E, Pascarella A, Capella C, Pedrinis E, et al. Primary low-grade gastric MALT lymphoma [Abstract]. Proceedings of the Annual Meeting of the American Society of Clinical Oncology. 1995; 14:A1232. Google Scholar2. Johnson PW, Price CG, Smith T, Cotter FE, Meerabux J, Rohatiner AZ, et al. Detection of cells bearing the t(14; 18) translocation following myeloablative treatment and autologous bone marrow transplantation for follicular lymphoma. J Clin Oncol. 1994; 12:798-805. Google Scholar3. Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993; 342:575-7. Google Scholar4. Rohatiner AZ. Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma. Ann Oncol. 1994; 5:397-400. Google Scholar5. Zucca E, Pinotti G, Roggero E, Comi MA, Pascarella A, Capella C, et al. High incidence of other neoplasms in patients with low-grade gastric MALT lymphoma. Ann Oncol. 1995; 6:(In press). Google Scholar Author, Article, and Disclosure InformationAuthors: Emanuele Zucca, MD; Enrico Roggero, MD; Franco Cavalli, MDAffiliations: Ospedale San Giovanni; 6500 Bellinzona; Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1996Volume 124, Issue 2Page: 275-276KeywordsAntibioticsChemotherapyClinical trialsGastrectomyHelicobacter pyloriLymphoid tissueLymphomaMALT lymphomaRetrospective studiesSurgery ePublished: 15 August 2000 Issue Published: 15 January 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...