tbuckley/cabot-search huggingface dataset:
A summary of mortality and incidence of cancer in men from the United Kingdom who participated in the United Kingdom's atmospheric nuclear weapon tests and experimental programmes
Authors: S C Darby, G M Kendall, T P Fell, J A O'Hagan, C R Muirhead, J R Ennis, A M Ball, J A Dennis, R Doll
Journal: BMJ (1988)

Altogether 22,347 men who participated in the United Kingdom's atmospheric nuclear weapon tests and experimental programmes in Australia and the Pacific Ocean between 1952 and 1967 were identified from the archives of the Ministry of Defence and followed up. Their mortality and incidence of cancer were compared with those in 22,326 matched controls selected from the same archives. The risk of mortality in the participants relative to that in the controls was 1.01 for all causes and 0.96 for all neoplasms. Thirty eight causes of death were examined separately. Significant differences in mortality were found for leukaemia, multiple myeloma, and other injury and poisoning, with higher rates in the participants, and for cancers of the prostate and kidney and chronic bronchitis, with higher rates in the controls. The mortality from leukaemia and multiple myeloma in the participants was slightly greater than would have been expected from national values (standardised mortality ratios of 113 and 111, respectively), but in the controls it was substantially lower (standardised mortality ratios of 32 and 0, respectively). Examination of the rates of leukaemia and multiple myeloma in groups of participants showed very little difference between groups characterised by recorded doses of external radiation or type of test participation and failed to indicate any specific hazard. Evidence obtained from participants who reported themselves voluntarily (or were reported by relatives or friends) suggested that 17% of participants may have been omitted from the main study group but that any resulting bias was small. Most of the differences observed between the participants and controls were interpreted as due to chance, but some may be due to differences in smoking habits. Participation in the test programme did not seem, in itself, to have caused any detectable effect on the participants' expectation of life, apart from possibly causing small risks of developing leukaemia and multiple myeloma.
The acute rise in serum fibrinogen concentration with severe exercise is influenced by the fibrinogen gene G-143-A polymorphism
Authors: Hugh Montgomery, Peter Clarkson, Don Nwose, Ferdaous Arca-Sedda, Mick Jubb, Michael World, John Deanfield, Jean McEwan, Stephen Humphries
Journal: Journal of the American College of Cardiology (1996)
Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments
Authors: Dorothée Duluc, Romain Banchereau, Julien Gannevat, Luann Thompson-Snipes, Jean-Philippe Blanck, Sandra Zurawski, Gerard Zurawski, Seunghee Hong, Jose Rossello-Urgell, Virginia Pascual, Nicole Baldwin, Jack Stecher, Michael Carley, Muriel Boreham, SangKon Oh
Journal: Genome Medicine (2014)

Dendritic cells localize throughout the body, where they can sense and capture invading pathogens to induce protective immunity. Hence, harnessing the biology of tissue-resident dendritic cells is fundamental for the rational design of vaccines against pathogens.Herein, we characterized the transcriptomes of four antigen-presenting cell subsets from the human vagina (Langerhans cells, CD14(-) and CD14(+) dendritic cells, macrophages) by microarray, at both the transcript and network level, and compared them to those of three skin dendritic cell subsets and blood myeloid dendritic cells.We found that genomic fingerprints of antigen-presenting cells are significantly influenced by the tissue of origin as well as by individual subsets. Nonetheless, CD14(+) populations from both vagina and skin are geared towards innate immunity and pro-inflammatory responses, whereas CD14(-) populations, particularly skin and vaginal Langerhans cells, and vaginal CD14(-) dendritic cells, display both Th2-inducing and regulatory phenotypes. We also identified new phenotypic and functional biomarkers of vaginal antigen-presenting cell subsets.We provide a transcriptional database of 87 microarray samples spanning eight antigen-presenting cell populations in the human vagina, skin and blood. Altogether, these data provide molecular information that will further help characterize human tissue antigen-presenting cell lineages and their functions. Data from this study can guide the design of mucosal vaccines against sexually transmitted pathogens.
Primer of Clinical Measurement of Blood Pressure
Authors: Irvine H. Page
Journal: JAMA (1962)

The last sentence of Burch and De-Pasquale's<i>Primer of Clinical Measurement of Blood Pressure</i>epitomizes the book. "Remember—no data is ( sic) better than wrong data!" Interest in hypertension and shock is at last great enough for clinicians to pay attention to so prosaic a procedure as blood pressure measurement. The book is of the quality we have learned to expect of Burch. It is simply-written, thorough, and full of many things, some of which one knows, some of which one thought one knew, and much of which one ought to know. The makeup of the book is good; the price is too high. A paperback edition would be preferable.
TCT-833 Meta-analysis of Long Term Outcomes of Intravascular Ultrasound versus Angiographic-Guided Percutaneous Coronary Intervention of Bifurcation Lesions
Authors: Vishal G. Patel, Subhash Banerjee, Kimberly Brayton, Houman Khalili, Dharam J. Kumbhani
Journal: Journal of the American College of Cardiology (2013)
The Merits of Geriatric Consultation
Authors: Edward W. Campion
Journal: JAMA (1987)

Consultation entails anticipation. The valued consultant brings the experience and expertise needed to anticipate complications as well as to discover elusive diagnoses. To benefit the patient, the consultant's wisdom must result in clear communication and reasonable compliance, both of which may be sizable challenges in themselves.<sup>1,2</sup> An ambitious goal of the consultant geriatrician is to avert the ills that can befall the hospitalized elderly. However, specific complications remain very difficult to anticipate. Only a minority of the major complications were anticipated in Becker and colleagues'<sup>3</sup>well-designed study appearing in this issue ofThe Journal: infection-related (10%), procedural (14%), trauma-related (28%), and medication-related (39%). None of the ten falls were predicted. In this study age alone seems once again to predict little except birth year. The art of averting complications is still imprecise. Effective interventions require more accurate clinical prediction. The powerful, though retrospective, wisdom of multivariate analysis will
The Time Has Come to Redefine the Classic Symptoms of Primary Hyperparathyroidism
Authors: Janice L. Pasieka
Journal: JAMA Surgery (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Diminution in energy expenditure during lactation.
Authors: P J Illingworth, R T Jung, P W Howie, P Leslie, T E Isles
Journal: BMJ (1986)

Energy expenditure at rest and in response to a meal and to an infusion of noradrenaline was measured in 12 lactating women and compared with that in seven bottle feeding women and seven non-pregnant, non-lactating controls. The energy response of the lactating women was remeasured after lactation stopped. During lactation the resting metabolic rate was unaltered but there was a reduced response to infusion of noradrenaline and to a meal, which increased to normal control values after lactation stopped. Such reductions in expenditure were not found in women who had been bottle feeding and were tested at a similar six to eight weeks post partum. These findings suggest that metabolic efficiency is enhanced in lactating women, who may not need to increase energy intake to the extent suggested by current recommended dietary allowances.
INFANTILE KALA AZAR IN SYRIA
Authors: Joseph K. Hitti
Journal: JAMA (1926)

Infantile kala azar has been reported in such Mediterranean countries as Italy, Greece, Malta and Crete, but no one has thus far reported its presence in Syria, although certain leading clinicians have suggested that possibility. Eighteen months ago I admitted to the pediatrics service of the American University Hospital S. Z., a boy, aged 7, who had been suffering for eight months from a chronic irregular febrile disease. The character of the fever curve and the laboratory exclusion of Malta fever and malaria made me suspect kala azar. The treatment consisted chiefly of antimony and potassium tar-trate intravenously. The patient made a complete recovery. Although splenic puncture was not permitted for the demonstration of Leishman-Donovan bodies, a diagnosis of kala azar was recorded. K. N., a boy, aged 7, was admitted, January 2, 1926. The examination for malaria and the agglutination tests for typhoid and Malta fever infections
Somatic and Psychiatric Aspects of Childhood Allergies.
Authors: Stuart M. Finch
Journal: JAMA (1963)

This monograph consists of 15 chapters by various authors, dealing with psychiatric, psychological, pediatric, and allergic aspects of childhood allergies. The authors range from psychoanalysts to research psychologists and from pediatricians to allergists. Some of the chapters are heavily weighted on the psychological side as, for example, the lead, "Psychopathology and Psychotherapy in the Allergies of Children." Other chapters offer detailed and even inordinately specific material of the field of allergy, such as the chapter on "Pollinosis in Childhood." Still others make an heroic effort to balance the presentation to include appropriate aspects of the physical and the emotional. The book deals with various allergic phenomena including those of the skin, the gut, and the nasopharynx, but asthma is given more space than any other syndrome. There is considerable material from The National Home for Asthmatic Children in Denver. This well-known institution has had a wealth of experience with asthmatic
Systolic Blood Pressure and Outcomes in Patients Hospitalized With Acute Heart Failure
Authors: Dae Hyun Kim, Hyunseok Kang
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Only 10 Seconds to Care: Help and Hope for Busy Clinicians
Authors: Howard S. Smith
Journal: Annals of Internal Medicine (2009)

Medical Writings: Book Notes1 December 2009Only 10 Seconds to Care: Help and Hope for Busy CliniciansHoward S. Smith, MDHoward S. Smith, MDFrom Albany Medical College, Albany, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-11-200912010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Harpham WS. 195 pages. Philadelphia: American Coll of Physicians; 2009. $26.95. ISBN 9781934465394. Order at www.acponline.org.Field of medicine: Palliative medicine.Format: Softcover book.Audience: General internists, oncologists, and palliative medicine specialists.Purpose: To provide practical, quick tips on patient communication with compassion in busy clinical practice.Content: Harpham describes personal and other vignettes, stories, and tips in an attempt to provide insight into various patient concerns, fears, thoughts, and emotions. The first 3 chapters correspond to the author's 3 steps to healthy survivorship: knowledge, hope, and action. The last 2 chapters address ways that clinicians may be helpful to ... Author, Article, and Disclosure InformationAffiliations: From Albany Medical College, Albany, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 2009Volume 151, Issue 11Page: 828KeywordsChildrenEmotionsFearHappiness ePublished: 1 December 2009 Issue Published: 1 December 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prognostic Value of Troponin T and I Among Asymptomatic Patients With End-Stage Renal Disease
Authors: Nadia A. Khan, Brenda R. Hemmelgarn, Marcello Tonelli, Christopher R. Thompson, Adeera Levin
Journal: Circulation (2005)

The prognostic usefulness of troponin enzymes in end-stage renal disease (ESRD) patients is controversial. To resolve this uncertainty of troponin as a prognostic tool, we conducted a systematic review to quantify the association between elevated troponin I or T and long-term total mortality among ESRD patients not suspected of having acute coronary syndrome.We conducted an unrestricted search from the MEDLINE, EMBASE, and DARE bibliographic databases to December 2004 using the terms troponin.mp. or exp troponin and exp kidney, exp renal, exp kidney disease exp renal replacement therapy. We also manually searched review articles and bibliographies to supplement the search. Studies were included if they were prospective observational studies, used cardiac-specific troponin assays, and evaluated long-term risk of death or cardiac events for asymptomatic ESRD patients. Two authors independently abstracted data on study and patient characteristics. Studies findings were stratified according to troponin T or I levels. We used a random-effects model to pool study results and tested for heterogeneity using chi2 testing and used funnel-plot inspection to evaluate the presence of publication bias. Data from 28 studies (3931 patients) published between 1999 and December 2004 were included in this review. Patients received dialysis for a median duration of 4 years, with a mean follow-up of 23 months. From the pooled analysis, elevated troponin T (>0.1 ng/mL) was significantly associated with increased all-cause mortality (relative risk, 2.64; 95% CI, 2.17 to 3.20). Although the prognostic effect sizes were all consistent with a positive relationship between troponin T and mortality, there was significant heterogeneity in the magnitude of these effect sizes (P=0.015). The funnel plot showed evidence of publication bias. Elevated troponin T was also strongly associated with increased cardiac death. Studies evaluating troponin I included a wide variety of assays and differing cut points, rendering synthesis of the study findings difficult.Elevated troponin T (>0.1 ng/mL) identifies a subgroup of ESRD patients who have poor survival and a high risk of cardiac death despite being asymptomatic. These findings suggest that troponin T is a promising risk stratification tool and may help frame therapeutic decisions. The clinical interpretation of elevated troponin I levels, however, remain unclear, largely because of the lack of standardization of assays.
Two thirds of Indian medical and dental journals publish unregistered studies
Authors: Z. Kmietowicz
Journal: BMJ (2013)

An analysis of Indian medical and dental journals has found that less than a third require authors to have a clinical trial registration number for studies submitted for publication despite this having been a national requirement for nearly four years.

For the survey, published in Indian Pediatrics (the publication of the Indian Academy of Pediatrics), researchers examined the “instructions for authors” of 30 journals that they identified from the National Library of Medicine Catalog …
Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus
Authors: Anil K. Mandal
Journal: Annals of Internal Medicine (2004)

Letters20 April 2004Losartan for Microalbuminuria in Normotensive Type 2 Diabetes MellitusAnil K. Mandal, MB, BSAnil K. Mandal, MB, BSFrom University of Florida, Jacksonville, FL 32209.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-8-200404200-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest Zandbergen and colleagues' article on losartan and microalbuminuria in normotensive patients with type 2 diabetes mellitus (1) and would like to raise several important issues.First, I have observed in my referral patients that reduction of albuminuria or proteinuria with angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor antagonists, such as losartan, happens only at the expense of reduction of glomerular filtration rate (GFR). It is quite evident in Zandbergen and colleagues' article that the losartan group had a mean reduction of almost 10% (9.7%) in creatinine clearance over a 10-week period. The decline in ...References1. Zandbergen AA, Baggen MG, Lamberts SW, Bootsma AH, de Zeeuw D, Ouwendijk RJ. Effect of losartan on microalbuminuria in normotensive patients with type 2 diabetes mellitus. A randomized clinical trial. Ann Intern Med. 2003;139:90-6. [PMID: 12859158] LinkGoogle Scholar2. Schrier RW, Estacio RO, Esler A, Mehler P. Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes. Kidney Int. 2002;61:1086-97. [PMID: 11849464] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Anil K. Mandal, MB, BSAffiliations: From University of Florida, Jacksonville, FL 32209. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Losartan on Microalbuminuria in Normotensive Patients with Type 2 Diabetes Mellitus Adrienne A.M. Zandbergen , Marinus G.A. Baggen , Steven W.J. Lamberts , Aart H. Bootsma , Dick de Zeeuw , and Rob J.Th. Ouwendijk Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus Kazuomi Kario and Kazuyuki Shimada Losartan for Microalbuminuria in Normotensive Type 2 Diabetes Mellitus Adrienne A.M. Zandbergen , Marinus G.A. Baggen , and Rob J.Th. Ouwendijk Metrics 20 April 2004Volume 140, Issue 8Page: 667-668KeywordsACE inhibitorsBloodCreatinineDrug therapyGlucoseHemoglobinHyperglycemiaMicroalbuminuriaProteinuriaType 2 diabetes ePublished: 20 April 2004 Issue Published: 20 April 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter
Authors: Yvonne Helmus, Jonas Denecke, Sviatlana Yakubenia, Peter Robinson, Kerstin Lühn, Diana L. Watson, Paraic J. McGrogan, Dietmar Vestweber, Thorsten Marquardt, Martin K. Wild
Journal: Blood (2006)
Erythrodermic syringotropic cutaneous T-cell lymphoma
Authors: A. Ah-Weng, S.R. Howatson, J.R. Goodlad, M.C. Patel, G. Gupta
Journal: British Journal of Dermatology (2003)

Summary Syringotropic cutaneous T‐cell lymphoma (CTCL) is a rare localized variant of CTCL, characterized histologically by eccrine gland and ductal hyperplasia surrounded by a dense syringotropic lymphocytic infiltrate. Previously reported only in men, we describe the first woman with syringotropic CTCL. Unusually, she presented with erythroderma, cutaneous nodules, poikilodermatous patches, widespread alopecia and lymphadenopathy.
Mogamulizumab for Relapsed Adult T-Cell Leukemia-Lymphoma: A Single-Institute Experience
Authors: S. Sato, H. Itonaga, Y. Onimaru, Y. Moriuchi, K. Yoshimi, Y. Yokoyama, T. Hara, R. Yamazaki, D. Niino, K. Ohshima
Journal: Annals of Oncology (2013)
IB-13 * DIFFERENCES IN THE EXPRESSION OF CD184, CD95, CD178 AND CD40 IN HUMAN GLIOMAS OF VARIOUS GRADES, BEFORE AND AFTER CHEMOTHERAPY
Authors: J. Werner, G. Rohn, R. Goldbrunner, M. Timmer
Journal: Neuro-Oncology (2014)

Cell surface molecules are very important in diagnostics and a cornerstone in the process of understanding the behavior of tumors. A better understanding of the immunological surface of human glioma cells could lead to a deeper understanding of tumor-invasion, -progress and potential therapies. Samples of different tumors were tested and compared. Groups were divided into WHO °II-, °III-tumors, primary glioblastoma (GBM), secondary GBM with-/without chemotherapy and a control group. Immunohistochemical staining with DAB and counterstaining with hematoxylin was performed with antibodies against CD184, CD95 and CD40 with 4 samples per group. Quantitative real-time PCR was performed and the relative expression levels of CD184, CD95, CD178 and CD40 analyzed; SDHA was used as a housekeeping gene. The cDNA was synthesized from RNA from 80 frozen human tumor samples, divided in the groups as described above, each group consisting of 10 samples. Both CD184 and CD95 showed a stronger staining in immunohistochemistry than CD40. In intra-group comparison, CD184, CD95 and CD40 showed increasing staining within rising WHO grade, whilst CD184 and CD95 made a big increase comparing °II and °III tumors, CD40 showed increasing staining comparing °III tumors and GBM. In quantitative real-time PCR, a significant higher expression level of CD95 and CD184 was found in primary glioblastoma, compared to the control tissue, also CD95 showed a higher expression in primary compared to secondary GBM. Stronger expression of cell surface molecules in higher-grade gliomas implicates an immunological change in the cell surface in the progression of low-grade tumors towards GBM. The difference of expression in primary and secondary GBM underlines the different genesis of these tumors. For a deeper understanding of mechanisms in tumor immunology of gliomas, further studies are necessary.