Treatment of Central Nervous System Lupus Erythematosus
Authors: JOHN S. SERGENT
Journal: Annals of Internal Medicine (1974)

Editorial Notes1 March 1974Treatment of Central Nervous System Lupus ErythematosusJOHN S. SERGENT, M.D., MICHAEL D. LOCKSHIN, M.D., F.A.C.P.JOHN S. SERGENT, M.D., MICHAEL D. LOCKSHIN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-3-413_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCentral nervous system (CNS) complications in patients with systemic lupus erythematosus are common and can be fatal (1, 2). Unlike lupus glomerulonephritis, lupus cerebritis is not characterized by reliable laboratory or clinical variables for diagnosis or prognosis. Tests for cerebrospinal fluid C4 (3) have not proved to be of practical clinical benefit (4).Recognizing the frequent dilemma the clinician faces in differentiating CNS disease caused by underlying systemic lupus erythematosus from that caused by infection, azotemia, hypertension, or drug effects, proper therapy remains a formidable problem. Several groups have reported good therapeutic results using high doses of corticosteroids—from 500 to...References1. ESTESCHRISTIAN DC: The natural history of systemic lupus erythematosus by prospective analysis. Medicine (Baltimore) 50:85-95, 1971 CrossrefMedlineGoogle Scholar2. DUBOIS E: Lupus Erythematosus. New York, McGraw-Hill Book Co., Inc., 1966, p. 202 Google Scholar3. PETZSHARPCOOPER LGN: Serum and cerebrospinal fluid complement and serum autoantibodies in systemic lupus erythematosus. Medicine (Baltimore) 50:259-275, 1971 CrossrefMedlineGoogle Scholar4. HADLERGERWINFRANK NRM: The fourth component of complement in the cerebrospinal fluid in systemic lupus erythematosus. Arthritis Rheum 16:507-521, 1973 CrossrefMedlineGoogle Scholar5. BENNETTHUGHESBYWATERS RGE: Neuropsychiatric problems in systemic lypus erythematosus. Br Med J 4:342-345, 1972 CrossrefMedlineGoogle Scholar6. DUBOISWIERZCHOWEICKICOX EMM: Causes of death in 212 cases of systemic lupus erythematosus (abstract). Arthritis Rheum 16:540-541, 1973 Google Scholar7. CHEATUMHURDSTRUNK DES: Renal histology and clinical course of systemic lupus erythematosus: a prospective study. Ibid., pp. 670-676 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Hospital for Special Surgery New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIntrathecal cytokines in systemic lupus erythematosus with central nervous system involvementNeuropsychiatric Manifestations of Systemic Lupus ErythematosusNeurological complications of connective tissue and other "collagen-vascular" diseasesSLE: The Value of Immunological Tests and Aspects of ManagementCytotoxic Agents in the Management of Systemic Lupus ErythematosusAseptic meningitis in systemic lupus erythematosusRecent observations on central nervous system lupus erythematosus 1 March 1974Volume 80, Issue 3Page: 413-414KeywordsCentral nervous systemClinical laboratoriesCorticosteroid therapyDrug therapyHypertensionInfectious diseasesLupus erythematosusLupus nephritisResearch laboratoriesSystemic lupus erythematosus Issue Published: 1 March 1974 PDF DownloadLoading ...