Fansidar and Hepatic Granulomas
Authors: H. P. Lazar, Robert Leo Murphy, John Phillip Phair
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 May 1985Fansidar and Hepatic GranulomasHAROLD P. LAZAR, M.D., ROBERT L. MURPHY, M.D., JOHN P. PHAIR, M.D.HAROLD P. LAZAR, M.D.Search for more papers by this author, ROBERT L. MURPHY, M.D.Search for more papers by this author, JOHN P. PHAIR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-722_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Because of an increasing awareness of the hazards of travel to areas harboring chloroquine-resistant strains of Plasmodium falciparum malaria, prophylaxis with Fansidar (sulfadoxine and pyrimethamine; Roche Laboratories, Nutley, New Jersey) has been advocated (1). Over a period of 13 months, however, we have seen two patients with severe reactions to Fansidar, with noncaseating granulomas documented by liver biopsy.A 75-year-old woman traveled to Madagascar, took chloroquine and Fansidar weekly for prophylaxis, and subsequently developed fatigue, anorexia, and malaise. Fever, rash, and shaking chills ensued. After she returned home and was hospitalized, neither lymphadenopathy nor splenomegaly was found....References1. WENIGERBLUMBERGCAMPBELLJONESMOUNTFRIEDMAN BRCTDS. High level chloroquine resistance of Plasmodium falciparum malaria acquired in Kenya. N Engl J Med. 1982;307:1560-2. CrossrefMedlineGoogle Scholar2. RIECKMANN K. Falciparum malaria: the urgent need for safe and effective drugs. In: CREGER WP, ed. Annual Review of Medicine, vol. 34. Palo Alto, California: Annual Reviews; 1983: 321-35. CrossrefGoogle Scholar3. LUDWIGAXELSEN JR. Drug effects on the liver. Dig Dis Sci. 1983;28:651-66. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Northwestern University Medical School Chicago, IL 60611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Impact of Malaria on Liver Enzymes: A Retrospective Cohort Study (2010–2017)Antibiotic induced liver injury: what about children?Hepatotoxicity of Antimicrobials and Antifungal AgentsGranulomatous Diseases of the LiverSevere hepatotoxicity and probable hepatorenal syndrome associated with sulfadiazineHepatotoxicity of Antibacterials: Pathomechanisms and Clinical DataDrug-related Hepatotoxicity and Acute Liver FailureAssessment of safety of the major antimalarial drugsGranulomas in the liverAntimalarial Drug ToxicityHepatotoxicity of antibiotics and antifungalsManagement of HIV-infected pregnant patients in malaria-endemic areas: Therapeutic and safety considerations in concomitant use of antiretroviral and antimalarial agentsHEPATOTOXICITY OF ANTIMICROBIAL, ANTIFUNGAL, AND ANTIPARASITIC AGENTSHepatotoxity11 Drug-induced and toxic granulomatous hepatitisUse of Pyrimethamine-Sulfadoxine (Fansidar) in Prophylaxis Against Chloroquine-Resistant Plasmodium falciparum and Pneumocystis cariniiRICHARD D. PEARSON, MD., ERIK L. HEWLETT, M.D.Fatal Hepatic Necrosis Due to Pyrimethamine-Sulfadoxine (Fansidar)BASIL J. ZITELLI, M.D., JEFFREY ALEXANDER, M.D., SUZANNE TAYLOR, M.D., Ph.D., KIRK D. MILLER, M.D., DENISE L. HOWRIE, Pharm.D., JOEL N. KURITSKY, M.D., THOMAS H. PEREZ, R.Ph., DAVID H. VAN THIEL, M.D.Antiprotozoal drugs 1 May 1985Volume 102, Issue 5Page: 722-722KeywordsFatigueFeversGranulomasLiverMalariaPlasmodium falciparumProphylaxisPyrimethamineRashesSplenomegaly Issue Published: 1 May 1985 PDF DownloadLoading ...