tbuckley/cabot-search huggingface dataset:
A.R.P. and Underground Car Parks for London
Authors: C. M. Beadnell
Journal: BMJ (1938)

SIR,-By extrapolating a graph curve of the numerical increase in recent years of private cars in Great Britain we can obtain ample evidence that unless measures are taken to restrict the daily flow of such vehicles into and out of the metropolitan area the already serious traffic congestion will shortly end in a literal impasse. If private cars on strictly official or trade business or owned by bona fide residents of London were alone allowed inside, and all cars whose occupants were concerned solely with shopping, visiting, theatres, dining, etc., were compelled to be parked outside, say, a sixto eight-mile radius from the Marble Arch, we should not be threatened with an alarming increase of the already existing difficulties of traffic organization. To accommodate prohibited cars commodious underground parking sites would have to be constructed on the principal radiating routes that link up the metropolis with outlying provinces. The cost of making such parks would admittedly be high, but there would ensue a good return for the initial outlay and cost of upkeep not only financially but in other and more important ways, such as from (1) parking fees and (2) work for the unemployed. The parks, being below ground and well protected overhead, would provide excellent clearing stations for wounded and shelters for thousands of residents evacuating London in the event of air raids. The A.R.P. authorities would have at their disposal and within easy access safe, well lighted and ventilated localities equipped with sanitary arrangements, water supply, and so forth. Adoption of such measures would defeat the disadvantages of a sudden incursion of large numbers of adults and children into country villages with inadequate housing and drainage facilities, and in which neither water nor food supply is capable of meeting the demands of a great number of suddenly introduced extra mouths.-I am, etc., CHARLES M. BEADNELL, Egham, Surrey, Nov. 4. Surgeon Rear-Admiral.
Lynch Syndrome in Patients With Colorectal Cancer
Authors: Uri Ladabaum, James M. Ford
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Platelet size in myocardial infarction.
Authors: H A Cameron, R Phillips, R M Ibbotson, P H Carson
Journal: BMJ (1983)

The mean platelet volume and platelet count were measured serially in 100 patients soon after myocardial infarction and again at a follow up clinic about seven weeks later. The results were compared with those in age matched controls. The mean platelet volume after infarction (mean 9.07 fl (SE 0.08] was significantly greater than in the controls (8.32 fl (SE 0.07); p less than 0.001), and was still raised at the follow up clinic (8.69 fl (SE 0.10); p less than 0.01). The mean platelet count on admission (275 X 10(9)/1 (SE 7] was significantly lower than in the control group (295 X 10(9)/1 (SE 5); p less than 0.05) and fell significantly during admission, with a mean change of -36 X 10(9)/1 (95% confidence limits -26, -45; p less than 0.01). At the follow up clinic the platelet count had risen to a level not significantly different from the admission value. As larger platelets are haemostatically more active, the finding of an increased mean platelet volume after myocardial infarction provides further evidence that abnormal platelet behaviour may be implicated in the process of infarction.
An Epigenetic Genome-Wide Screen Identifies <i>SPINT2</i> as a Novel Tumor Suppressor Gene in Pediatric Medulloblastoma
Authors: Paul N. Kongkham, Paul A. Northcott, Young Shin Ra, Yukiko Nakahara, Todd G. Mainprize, Sidney E. Croul, Christian A. Smith, Michael D. Taylor, James T. Rutka
Journal: Cancer Research (2008)

Abstract Medulloblastoma (MB) is a malignant cerebellar tumor that occurs primarily in children. The hepatocyte growth factor (HGF)/MET pathway has an established role in both normal cerebellar development as well as the development and progression of human brain tumors, including MB. To identify novel tumor suppressor genes involved in MB pathogenesis, we performed an epigenome-wide screen in MB cell lines, using 5-aza-2′deoxycytidine to identify genes aberrantly silenced by promoter hypermethylation. Using this technique, we identified an inhibitor of HGF/MET signaling, serine protease inhibitor kunitz-type 2 (SPINT2/HAI-2), as a putative tumor suppressor silenced by promoter methylation in MB. In addition, based on single nucleotide polymorphism array analysis in primary MB samples, we identified hemizygous deletions targeting the SPINT2 locus in addition to gains on chromosome 7 encompassing the HGF and MET loci. SPINT2 gene expression was down-regulated and MET expression was up-regulated in 73.2% and 45.5% of tumors, respectively, by quantitative real-time PCR. SPINT2 promoter methylation was detected in 34.3% of primary MBs examined by methylation-specific PCR. SPINT2 reexpression in MB cell lines reduced proliferative capacity, anchorage independent growth, cell motility in vitro, and increased overall survival times in vivo in a xenograft model (P &amp;lt; 0.0001). Taken together, these data support the role of SPINT2 as a putative tumor suppressor gene in MB, and further implicate dysregulation of the HGF/MET signaling pathway in the pathogenesis of MB. [Cancer Res 2008;68(23):9945–53]
Role of anaerobes in cerebral abscesses of sinus origin.
Authors: A Grace, A Drake-Lee
Journal: BMJ (1984)

3 observations de tels abces, contenant une flore mixte aerobie et anaerobie, dont des microorganismes resistant a la penicilline. Le metronidazole devrait etre ajoute au traitement si les premiers resultats ne sont pas satisfaisants
Full Prescription Coverage Versus Usual Prescription Coverage After Coronary Artery Bypass Graft Surgery
Authors: Alexander Kulik, Nihar R. Desai, William H. Shrank, Elliott M. Antman, Robert J. Glynn, Raisa Levin, Lonny Reisman, Troyen Brennan, Niteesh K. Choudhry
Journal: Circulation (2013)

Eliminating out-of-pocket costs for patients after myocardial infarction (MI) improves adherence to preventive therapies and reduces clinical events. Because adherence to medical therapy is low among patients treated with coronary artery bypass graft surgery (CABG), we evaluated the impact of providing full prescription coverage to this patient subgroup.The MI Free Rx Event and Economic Evaluation (FREEE) trial randomly assigned 5855 patients with MI to full prescription coverage or usual formulary coverage for all statins, β-blockers, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers. We assessed the impact of full prescription coverage on adherence, clinical outcomes, and healthcare costs using adjusted models among the 1052 patients who underwent CABG at the index hospitalization and 4803 who did not. CABG patients were older and had more comorbid illness (P<0.01). After MI, CABG patients were significantly more likely to receive β-blockers and statins but were less likely to receive angiotensin-converting enzyme inhibitor/angiotensin receptor blocker therapy (P<0.01). Receiving full drug coverage increased rates of adherence to all preventative medications after CABG (all P<0.05). Full coverage was also associated with nonsignificant reductions in the rate of major vascular events or revascularization for patients treated with CABG (hazard ratio, 0.91; 95% confidence interval, 0.66-1.25) or without CABG (hazard ratio, 0.93; 95% confidence interval, 0.82-1.06), with no interaction noted (Pint=NS). After CABG, full prescription coverage significantly reduced patient out-of-pocket spending for drugs (P=0.001) without increasing overall health expenditures (P=NS).Eliminating drug copayments after MI provides consistent benefits to patients treated with or without CABG, leading to increased medication adherence, trends toward improved clinical outcomes, and reduced patient out-of-pocket expenses.
Primed T Cells from BALB/c mouse exhibit cross reactivity between a bacterial peptide and a peptide containing the immunodominant epitope of lipocalin allergen Bos d 2
Authors: S.A. Saarelainen, A.K. Immonen, M.A. Rytkönen-Nissinen, T.T. Kinnunen, T.I. Virtanen
Journal: Journal of Allergy and Clinical Immunology (2005)
Accumulation of Dendritic Cells and Increased CCL20 Levels in the Airways of Patients with Chronic Obstructive Pulmonary Disease
Authors: Ingel K. Demedts, Ken R. Bracke, Geert Van Pottelberge, Dries Testelmans, Geert M. Verleden, Frank E. Vermassen, Guy F. Joos, Guy G. Brusselle
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation. It is unclear if dendritic cells (DC) participate in this inflammatory process.To evaluate the presence of DC in small airways of patients with COPD.We evaluated DC infiltration in small airways by immunohistochemistry in patients with COPD (stage I-IV), never-smokers, and smokers without COPD. Chemokine ligand 20 (CCL20, the most potent chemokine in attracting DC) was determined in total lung by RT-PCR and in induced sputum by enzyme-linked immunsorbent assay. Chemokine receptor 6 (CCR6, the receptor for CCL20) expression on human pulmonary DC was evaluated by RT-PCR and flow cytometry.There is a significant increase in DC number in the epithelium (p = 0.007) and adventitia (p = 0.009) of small airways of patients with COPD compared with never-smokers and smokers without COPD. DC number in epithelium and adventitia increases along with disease severity. CCL20 mRNA expression in total lung and CCL20 protein levels in induced sputum are significantly higher in patients with COPD compared with never-smokers (p = 0.034 for CCL20 mRNA and p = 0.0008 for CCL20 protein) and smokers without COPD (p = 0.016 for CCL20 mRNA and p = 0.001 for CCL20 protein). DC isolated from human lung express CCR6 both at mRNA and at protein level.This is the first description of airway infiltration by DC in COPD. Moreover, interaction between CCL20 and CCR6 provides a possible mechanism for accumulation of DC in the lungs in COPD.
Points from Letters: Routine Refractions
Authors: D. P. Gurd
Journal: BMJ (1971)

585 leads to considerable loss of efficiency and difficulties both in administration and medical care.It is one of the best health services that I have seen abroad, but does not come near to matching our own service.It is quite true that IsraAi medical students are not educated in general practice, but I cannot agree with Dr. Smith that this is "through no fault of the authors of the book."Dr. K. J. Mann is the D`rector-General of thv Hadassah (not Hadassar) University Hospital and could un- doubtedly have influenced the Medical School to permit students to attend the communal health centre.Perhaps the reason why the medical school authorities were unwilling to do so is because it is a well-known fact in Israel that the standard of medicine in health centres is very poor compared with the hospitals, largely owing to the obstinate refusal of the politicians to allow the various health insurance schemes to be nationalized.I do not believe that socialized medicine can work without nationalization.-Iam, etc.,
A quarter of diabetic patients miss out on annual foot checks, UK survey warns
Authors: S. Mayor
Journal: BMJ (2011)

One in four patients with diabetes have not had their feet checked in the previous year, despite annual foot checks being recommended as part of routine care to prevent complications, a new UK online survey shows.

Diabetes UK surveyed people with diabetes who were in contact with the charity between 8 September and 8 November 2011, asking them about 15 healthcare checks and specialist services that it considers essential to good care. Two thirds of the 7184 respondents had type 2 diabetes and one third had type 1 diabetes. The results showed that 25.4% of …
Another Cause for Litigation
Authors: Stephen L. Liston
Journal: JAMA (1985)

To the Editor.—  Most physicians are aware of the continuing crisis in malpractice litigation. However, as the following examples will illustrate, we are encountering a new and pernicious type of litigation between patient and physician.  In the first instance, a child required a tracheotomy for upper airway obstruction. It took several days longer than originally anticipated to extubate this child, and the parents initiated a legal action to have the surgeon pay for those extra days in the hospital.  In the second case, a child with otitis media needed the insertion of tympanostomy tubes. The parents had no medical insurance and were advised to inquire whether the hospital's free bed fund would cover the operating room costs. The surgeon inserted the tympanostomy tubes at no charge to the parents, but the patient apparently did not qualify for the free bed fund and received a bill from the hospital. The parents
ABNORMAL FUNCTION OF THE LIVER
Authors: WALTMAN WALTERS
Journal: JAMA (1925)

Life depends on the oxidation of carbon. Carbohydrates are used as glucose, stored as glycogen in the liver, and the excess deposited in the body as fat. Unfortunately, fats cannot, to any considerable extent, be reconverted into glucose; furthermore, sufficient glucose must be available to maintain combustion of fats; otherwise the higher fatty acids will not undergo complete combustion, and acetone and diacetic acid will appear in the tissues and cause a toxemia, which in the more severe grades may terminate in coma, as in cases of diabetes.  On the contrary, proteins can, to a considerable extent, be converted into glucose, but they contain nitrogen. Under stress, as in cases of starvation or hepatic disease, sufficient glucose is not available; the protein tissues of the body are broken down for the purpose of producing the necessary glucose, and the resultant excess nitrogen must be excreted in the urine as urea
Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia
Authors: N C P Cross, H E White, D Colomer, H Ehrencrona, L Foroni, E Gottardi, T Lange, T Lion, K Machova Polakova, S Dulucq, G Martinelli, E Oppliger Leibundgut, N Pallisgaard, G Barbany, T Sacha, R Talmaci, B Izzo, G Saglio, F Pane, M C Müller, A Hochhaus
Journal: Leukemia (2015)

Treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors has advanced to a stage where many patients achieve very low or undetectable levels of disease. Remarkably, some of these patients remain in sustained remission when treatment is withdrawn, suggesting that they may be at least operationally cured of their disease. Accurate definition of deep molecular responses (MRs) is therefore increasingly important for optimal patient management and comparison of independent data sets. We previously published proposals for broad standardized definitions of MR at different levels of sensitivity. Here we present detailed laboratory recommendations, developed as part of the European Treatment and Outcome Study for CML (EUTOS), to enable testing laboratories to score MR in a reproducible manner for CML patients expressing the most common BCR-ABL1 variants.
Does the presence of electrocardiographic left ventricular hypertrophy predict one-year mortality in non-ST elevation acute coronary syndromes?
Authors: Michael S. Lauer, Yuling Fu, Wei-Ching Chang, Robert M. Califf, Maarten Simoons, Lars Wallentin, Eric J. Topol, Paul W. Armstrong
Journal: Journal of the American College of Cardiology (2003)
Dioxin Levels in Vietnam Veterans-Reply
Authors: John M. Karon
Journal: JAMA (1989)

In Reply. —  The purpose of the Centers for Disease Control study was to attempt to validate an Agent Orange exposure index on the basis of a review of military records of Army ground combat troops. As described in the study, these showed dates and locations served. Therefore, the study did not focus on veterans whose jobs involved handling herbicides, such as those men who had served in the chemical corps or in the Air Force Operation Ranch Hand unit (the sprayers of Agent Orange). Our conclusions, therefore, are stated as applying only to Army ground combat troops. Our focus on the more general veteran was intentional. Congress directed us to study the experience of the majority of troops. We are aware that selected veterans whose jobs involved repeated handling of herbicides may have had greater exposure. To investigate possible health effects of Agent Orange exposure among Ranch Hand veterans,
For AIDS Treatment, Vaccines, Now Think Genes
Authors: Marsha F. Goldsmith
Journal: JAMA (1993)

"FOR EVERY PROSPECT there are problems," says William Haseltine, MD, PhD, about the chances of having either an effective treatment or a vaccine for infection with the human immunodeficiency virus (HIV) by the turn of this century—or later. Despite the many advances that have given scientists previously undreamed-of opportunities for intervention against the virus linked with acquired immunodeficiency syndrome (AIDS), Haseltine says, "We don't have the biological parts to get started on a 'Manhattan Project.' We are still in the discovery process. We don't have the knowledge we need to know that any of the possibilities are going to work." The Harvard Medical School professor of pathology spoke at the annual meeting of the American Association for the Advancement of Science, held in Boston, Mass. An AIDS researcher since the syndrome was defined, Haseltine, who is also chief, Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, said, "Do you want
Rules and rote: Beyond the linguistic either-or fallacy
Authors: Robert Schreuder, Nivja de Jong, Andrea Krott, Harald Baayen
Journal: Behavioral and Brain Sciences (1999)

We report an experiment that unambiguously shows an effect of full-form frequency for fully regular Dutch inflected verbs falling into Clahsen's “default” category, negating Clahsen's claim that regular complex words in the default category are not stored.
Legal Concerns and the Influenza Vaccine Shortage
Authors: Michelle M. Mello
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New health secretary vows to continue NHS reform agenda
Authors: O. Dyer
Journal: BMJ (2003)

The surprise departure of Alan Milburn as health secretary will not derail the NHS reform agenda of Tony Blair's government, says his successor, John Reid. Dr Reid told BBC Radio 4's Today programme last week that he has been an “arch-moderniser” for 20 years, and “a Blairite before Blair was ever heard of.”



Health secretary John Reid has been described as “abrasive,” “uncompromising,” and a “rottweiler”

PA



Dr Reid also dismissed complaints that as a Scottish MP he was ill suited to push through the English project of foundation hospitals. “When they appointed Sven-Goran Eriksson as England manager, there was a huge fuss …
Effects of inhaled nitric oxide on methacholine-induced bronchoconstriction: a concentration response study in rabbits
Authors: M Hogman, SZ Wei, C Frostell, H Arnberg, G Hedenstierna
Journal: European Respiratory Journal (1994)

Inhaled nitric oxide (NO), at a concentration of 80 ppm, counters the increase in respiratory resistance (Rrs) induced by methacholine, but fails to prevent a reduction in lung compliance (Crs) in a rabbit model. This study reports the effects of 3, 30 and 300 ppm of inhaled NO. New Zealand White rabbits were intubated and mechanically ventilated with 30% oxygen during neurolept anaesthesia. Methacholine (3 mg.ml-1) was nebulized, with or without NO inhalation. Inhalation of 3 and 30 ppm NO had no effect on the induced bronchoconstriction, whereas 300 ppm fully blocked the increase in Rrs. The decrease in Crs due to methacholine was not countered by 3, 30 or 300 ppm NO. On the contrary, inhalation of 300 ppm NO in itself decreased Crs from 5.0 +/- 0.1 to 4.3 +/- 0.1 ml.cmH2O-1. Also, mean arterial pressure (60 +/- 7 to 54 +/- 5 mmHg), alveolar-arterial oxygen tension gradient (0.8 +/- 0.8 to 2.3 +/- 1.8 kPa) and methaemoglobin (0.5 +/- 0.2 to 1.5 +/- 0.5%) changed significantly on inhalation of NO 300 ppm prior to methacholine challenge. We conclude that 3 and 30 ppm NO inhalation does not alter methacholine-induced bronchoconstriction. Inhalation of 300 ppm NO blocks an increase in resistance but fails to counter the reduction in compliance due to methacholine. This suggests that the bronchodilating effects of NO in rabbits in vitro are confined to the large airways.
Notes to the Class — First Day
Authors: Katharine Treadway
Journal: New England Journal of Medicine (2005)

Interview with Dr. Katharine Treadway on teaching compassion to medical students. (08:15)Download I watch the second-year students file into the Ether Dome for their first day of my “Patient–Doctor 2” course. For me, this course marks their true entry into medical school. Here, they will refine their history-taking skills, building on their knowledge of pathophysiology and disease; they will learn how to perform a physical examination; and they will touch a living stranger's body as clinicians for the first time. For them, right now, these are just skills to be learned. They do not see how they will be transformed by them. They know that these newfound abilities will open the door . . .