tbuckley/cabot-search huggingface dataset:
The Musculoskeletal System: Embryology, Biochemistry, and Physiology
Authors: Irwin M. Siegel
Journal: JAMA (1983)

<b>The Musculoskeletal System: Basic Processes and Disorders</b>, edited by Frank C. Wilson, ed 2; 287 pp, 125 illus, $32.50, Philadelphia, JB Lippincott Co, 1983. A fresh look at basic science is always rewarding. These books, although different in several respects, serve to remind us that the growing edge of orthopedic practice interfaces closely with the basic processes of the musculoskeletal system. In each I found much that was stimulating, interesting, and constructive. Dr Cruess has engaged 15 of his colleagues, most from Montreal institutions (including McGill University, Shriner's Hospital for Crippled Children, the Royal Victoria Hospital, and the Montreal Neurological Institute), to organize the vast body of basic science knowledge "in a way that should be understandable to someone either in training for a clinical discipline or practicing a specialty." The stated ultimate objective of this book is "to improve the scientific foundation of the practice of medicine." He and
Physiology of Exercise.
Authors: Frederic T. Jung
Journal: JAMA (1963)

The third edition of this book was reviewed inThe JournalApril 4, 1959 (<b>169</b>:1689). This fourth edition, completely revised and reset, carries on the purpose of analyzing the responses of the human body to exercise. More references are given than before, especially to recent work, in support of specific statements. The first part describes neuromuscular activity in terms of the physiology of muscular, nervous, and connective tissue; subsequent parts deal with circulatory and respiratory adjustments, with fatigue and training, and with fitness and health. The authors have made the table of conversion factors harder to use by abandoning the horizontal guidelines between the widely-spaced columns, but they have improved the glossary by reserving capitals for proper nouns and using a two-column page. Some instructive illustrations used in the third edition are missing in the fourth, but the book is still very attractive in appearance and style. It is
Reply to Santhanam Sundar's Letter to the Editor re: Arnulf Stenzl, Nigel C. Cowan, Maria De Santis, et al. Treatment of Muscle-Invasive and Metastatic Bladder Cancer: Update of the EAU Guidelines. Eur Urol 2011;59:1009–18
Authors: Arnulf Stenzl, Nigel C. Cowan, Maria De Santis, Markus A. Kuczyk, Axel S. Merseburger, Maria José Ribal, Amir Sherif, J. Alfred Witjes, Thierry Lebret
Journal: European Urology (2012)
Early reporting of myocardial infarction: impact of an experiment in patient education.
Authors: J M Rowley, J D Hill, J R Hampton, J R Mitchell
Journal: BMJ (1982)

Many deaths from myocardial infarction occur before medical help is sought. A campaign was mounted in Nottingham ("Nottingham Heartwatch") to encourage early reporting. A total of 13 828 men and women aged 40 and over registered with three general practices were asked to telephone a hospital-based number if they developed chest pain lasting for more than 10 minutes. Patients from study practices reported chest pain earlier after our invitation than they had before and also earlier than patients from control practices. While accepting the advice to call early some patients from the study practices ignored our special number and telephoned their general practitioner. The calls received on the Heartwatch line yielded a lower percentage of definite and probable infarcts than the calls received by the patients9 own doctors. The way in which the characteristics of the study practices might have influenced this difference is discussed since it has considerable implications for larger-scale attempts to bring patients with suspected myocardial infarction under medical care at the earliest opportunity.
Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis
Authors: Hisaki Nagai, Yong Sung Kim, Kyung-Tai Lee, Mi-Young Chu, Noboru Konishi, Jiro Fujimoto, Masaru Baba, Ken-ichi Matsubara, Mitsuru Emi
Journal: Journal of Hepatology (2001)
“Pseudo” cholelithiasis: sequelae of minimally invasive cholecystectomy with maximum surprise – an unusual case
Authors: C. Palanivelu, P. Jategaonkar, M. Rangarajan, B. Srikanth
Journal: Endoscopy (2009)

Laparoscopic cholecystectomy is the gold standard for managing cholecystolithiasis, despite being associated with a higher incidence of gallbladder perforations (10 % – 40 %) [1] and spillage of gallstones (6 % – 30 %) than is the open procedure. Although rare (0.08 % – 0.3 %) [2], gallstone spillage could potentially lead to serious morbidity such as gallstone abscesses, which can present from as early as 1 month to as late as 20 years after the procedure, almost anywhere in the abdominal cavity [3].
Emergency Medicine-Reply
Authors: John C. Johnson
Journal: JAMA (1985)

In Reply.—  Being versed in  dogma of  American College of Surgeons as it relates to  cervical spine and its priority in trauma patients, I feel that Emergency Medicine fails to convey  proper current approach to patient management in this vital area of patient care. In chapter 12, The Critically Injured Patient, patient assessment is described as note if  spinal cord is in danger. Assessment of  patient's dorsum is accomplished utilizing a log-rolling maneuver while someone supports  head and neck.... Later in  chapter when a cervical spine injury is suspected, the neck should be splinted with sandbags. Later inhospital discussions of cervical injuries, in particular, address  use of cervical tongs, without mentioning other initial stabilization techniques.  Standard aspects of current early management, such as a rigid cervical collar, in-line axial traction by attendant, or simply stationing a person to literally hold
Current Concepts of Bone Metabolism
Authors: LEO LUTWAK
Journal: Annals of Internal Medicine (1974)

Bone morphogenesis is a function of biochemical components of the organic matrix of bone, which consists of a noncollagenous protein resistant to solution, a solid support fibrous protein (collagen), and a neutral proteinase that degrades the noncollagenous protein. The proteinase functions in association with inhibitors that retard destruction of the protein and account for survival of morphogenetic activity in bone matrix. Calcitonin mediates another control mechanism for bone formation; it produces a decrease in osteoclasts, a delayed increase in osteoblasts, and significantly lowers plasma calcium and hydroxyproline concentrations in patients with increased bone turnover. Although calcitonin administration does not have a significant hypocalcemic effect in normal persons, the urinary excretion of dializable and nondializable peptides containing hydroxyproline is decreased. Chronic dietary insufficiency of calcium or excess of phosphate, or both, may lead to secondary nutritional hyperparathyroidism in animals and man, manifested primarily by increased resorption of trabecular bone. Osteoporosis of the jaw, leading to periodontal disease, is suggested as the precursor of the systemic osteoporosis seen in older patients.
Histamine release from rodent and human mast cells induced by protoporphyrin and ultraviolet light: studies of the mechanism of mast-cell activation in erythropoietic protoporphyria
Authors: RENEE A. GLOVER, CYNTHIA S. BAILEY, KIM E. BARRETT, S.I. WASSERMAN, IRMA GIGLI
Journal: British Journal of Dermatology (1990)

We report that protoporphyrin (PP) and ultraviolet light (UVA) induces histamine release from rat peritoneal mast cells, mouse bone marrow mast cells and human cutaneous mast cells in a dose‐ and temperature‐dependent manner. The mast‐cell activation was associated with loss of membrane integrity and inhibited by the hydrogen peroxide scavenger, catalase. Histamine release was independent of extracellular calcium in the rodent mast cells, but was markedly reduced in the absence of calcium in human cells. These findings indicate that PP and UVA induce mast‐cell‐mediator release by a process that may involve hydrogen peroxide formation. There appear to be differences in response to PP and UVA between rodent and human mast cells.
Braking Bad: Blockade of Inhibitory Pathways Improves Interleukin-15 Therapy
Authors: William E. Carson
Journal: Clinical Cancer Research (2010)

Blockade of the CTLA-4 and PD-1 inhibitory pathways in T cells via the administration of neutralizing antibodies at the time of interleukin (IL)-15 therapy markedly enhanced the survival of tumor-bearing mice as compared with those receiving IL-15 alone or IL-15 in combination with just one of the antibodies.
Regulatory mechanisms in cell-mediated immune responses. V. H-2 homology requirements for the production of a minor locus-induced suppressor factor.
Authors: D L Kastner, R R Rich, L Chu, S S Rich
Journal: The Journal of Experimental Medicine (1977)

A mixed leukocyte reaction suppressor factor is produced by spleen cells sensitized in vivo and restimulated in vitro across non-H-2 antigenic barriers. Cells capable of producing this factor appear in the spleens of minor locus-immunized animals later than in animals sensitized to major histocompatibility complex-encoded antigens. However, both H-2 and non H-2-induced factors suppress proliferative responses to any alloantigen. Splenocytes from animals immunized with H-2-identical, minor locus-disparate cells produce suppressor factor in vitro only when restimulated with cells sharing both H-2 and non-H-2 antigens with the in vivo stimulators.
Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage
Authors: Krishna S. Tummala, Ana L. Gomes, Mahmut Yilmaz, Osvaldo Graña, Latifa Bakiri, Isabel Ruppen, Pilar Ximénez-Embún, Vinayata Sheshappanavar, Manuel Rodriguez-Justo, David G. Pisano, Erwin F. Wagner, Nabil Djouder
Journal: Cancer Cell (2014)
Pouchitis--recurrence of the inflammatory bowel disease?
Authors: P Luukkonen, H Jarvinen, M Tanskanen, A Kahri
Journal: Gut (1994)

The incidence and characteristics of reservoir inflammation after restorative proctocolectomy for ulcerative colitis were studied in a series of 179 patients. The median follow up time was 27 months (range 6-80). Pouchitis occurred in 36 patients (20%) and nine of these (5%) developed a chronic, persisting pouchitis. There were no pouch failures as a result of pouchitis and no significant adverse effect on longterm functional outcome. The overall cumulative risk to develop pouchitis four years after surgery was 23%. The risk of pouchitis is unpredictable on clinical grounds except that there were significantly less patients with left sided colitis in the group who subsequently developed pouchitis. Morphological and histochemical studies showed a greater degree of colonic metaplasia in the pouch mucosa in patients with pouchitis and patients with a chronic pouchitis had the highest degree of changes. The results support the view that pouchitis is a novel manifestation of inflammatory bowel disease in ileal mucosa that has changed slowly to a colon like mucosa.
Sudden coronary death in the United States: 1980-1985.
Authors: R F Gillum
Journal: Circulation (1989)

To describe patterns of an indicator of sudden coronary death, data from the National Center for Health Statistics were examined for deaths occurring out of hospital and in the emergency room (OH/ER) from 1980 to 1985 in 40 states. In 1985, 56% of ischemic heart disease deaths occurred OH/ER among persons aged 35-74 years. The percentage occurring OH/ER declined with age, was higher in men than women, and higher in blacks than whites. At age 55-64, 61% of ischemic heart disease deaths in white and 66% in black men occurred OH/ER. Between 1980 and 1985, age-adjusted death rates in white men aged 35-74 years declined 19% for OH/ER and 18% for in-hospital ischemic heart disease deaths. The percentage of deaths in ER increased. The decline in deaths occurring OH/ER accounted for 61% of the total absolute decline in ischemic heart disease death rate in white men, 55% in white women, and about 70% in nonwhites. The decline in rates of death OH/ER should encourage further efforts at preventing coronary heart disease and improving emergency medical services.
Erythropoietin affects the maturation pattern of fetal G‐CSF‐responsive progenitors
Authors: Robert D. Christensen, Gerald Rothstein
Journal: American Journal of Hematology (1992)

A transient hyporegenerative neutropenia has been reported in neonates, but not in older children or adults, undergoing treatment with recombinant erythropoietin (epo). Monocytopenia has not been reported. We postulated that epo might selectively reduce the responsiveness of neonatal progenitors to Granulocyte Colony-Stimulating Factor (G-CSF), while not similarly affecting their responsiveness to Macrophage Colony-Stimulating Factor (M-CSF). To test this hypothesis two types of experiments were performed. First, progenitors of adult or fetal origin were pre-incubated with epo (or control), then washed, and their responsiveness to G-CSF and M-CSF evaluated in clonogenic culture assays. Second, clonogenic maturation was initiated using either G-CSF or M-CSF, after which the effect of a late addition of epo to the developing clones was evaluated. Indeed, pre-incubation with epo resulted in production of fewer neutrophils from fetal progenitors grown in G-CSF (P less than 0.001), but it did not reduce the number of macrophages generated from progenitors grown in M-CSF. Adding epo to the already-developing G-CSF-responsive and M-CSF-responsive adult and fetal clones did not alter colony development. Thus, epo appears to have an action on G-CSF-responsive, but not-M-CSF-responsive fetal progenitors, resulting in reduced production of neutrophils. This effect is no longer apparent, however, when progenitors have matured to the 8-cell clone stage.
Rastafarianism and the vegans syndrome.
Authors: M Campbell, W S Lofters, W N Gibbs
Journal: BMJ (1982)

Clearly, multiple sclerosis plaques may mimic gliomas on computed tomography.Absence of a mass effect has been suggested as a diagnos- tic criterion for demyelination,5 but confusion may still occur.Doubts about the nature of such a lesion may be resolved by either biopsy or serial computed tomography.
THE DOCTOR AS A POLITICIAN.
Authors: CHAS J. WHALEN
Journal: JAMA (1899)

The doctor is virtually a political nonentity. In our legislative halls we are practically without representation, and the few that are engaged in politics are really not pursuing the practice of medicine. The rank and file of physicians are not, as a rule, particularly concerned in the solution of problems calculated to affect medicine politically. Is it to be wondered at, then, that we fail to gain for these numerous and all-important questions in which the profession is deeply interested that fair consideration which they desire? There exists a class in the medical profession who believe medicine and politics entirely incompatible, and consider politics so corrupt that no honest man can have anything to do with it without being contaminated thereby, or that only the office-seeker is benefited by the elections which occur from time to time ; therefore, he must take care of his own interests as best he
The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.
Authors: M Mall, M Bleich, R Greger, R Schreiber, K Kunzelmann
Journal: Journal of Clinical Investigation (1998)

Cystic fibrosis (CF) airway cells, besides their well-known defect in cAMP-dependent Cl- conductance, are characterized by an enhanced Na+ conductance. In this study we have examined the Na+ conductance in human respiratory tract by measuring transepithelial voltage and resistance (Vte, Rte) and by assessing membrane voltages (Vm) of freshly isolated airway epithelial cells from CF and non-CF patients. Basal amiloride inhibitable (10 micromol/liter) equivalent short circuit current (Isc = Vte/Rte) was significantly increased in CF compared with non-CF tissues. After stimulation by forskolin (10 micromol/liter) a significant depolarization of Vm corresponding to the cAMP-dependent activation of a Cl- conductance was observed in non-CF but not in CF airway cells. In non-CF tissue but not in CF tissue the effects of amiloride and N-methyl-D-glucamine on Vm were attenuated in the presence of forskolin. Also the amiloride-inhibitable Isc was significantly reduced by forskolin (1 micromol/liter) and isobutylmethylxanthine (IBMX; 100 micromol/liter) only in non-CF tissue. We conclude that cystic fibrosis transmembrane conductance regulator acts as a downregulator of epithelial Na+ channels in human airways. This downregulation of epithelial Na+ channels is absent in CF airways, leading to hyperabsorption and to the characteristic increase in mucus viscosity.
F-18 FDG PET Imaging of Metastases From Soft Tissue Myoepithelioma
Authors: Ba D. Nguyen
Journal: Clinical Nuclear Medicine (2005)

Myoepithelioma is an uncommon tumor composed of epithelioid cells and chondromyxoid elements. Its diagnosis is exclusively histopathologic with complex histochemical characteristics. This neoplasm usually exhibits a low level of aggressiveness and is well treated with adequate surgical resection. Rare is the setting of diffuse soft tissue metastasis from malignant degeneration as reported in the following case presentation. In this case, F-18 FDG PET provides a comprehensive evaluation and staging in the postoperative and postradiation course of this rare neoplasm.
212 BILIARY STONE OR CAST DEVEOLPMENT IN PATIENTS WITH POSTOPERATIVE STRICTURE AFTER ORTHOTROPIC LIVER TRANSPLANTATION
Authors: S.H. Lee, K.Y. Yang, J.K. Seo, S.M. Woo, J.K. Park, J.-H. Hwang, J.-W. Kim, S.-H. Jeong, Y.J. Jung, K.S. Shu, J.K. Ryu, Y.-T. Kim, Y.B. Yoon
Journal: Journal of Hepatology (2008)
Atopic disorders among Estonian schoolchildren in relation to tuberculin reactivity and the age at BCG vaccination
Authors: T. Annus, S. M. Montgomery, M.‐A. Riikjärv, B. Björkstén
Journal: Allergy (2004)

Background: Published data about a relationship of atopic diseases to Bacillus Calmette‐Guérin (BCG) vaccination and tuberculin responses are inconsistent. Our aim was to determine this association in a country with a low prevalence of allergies. Methods: A random sample of 10–11‐year‐old schoolchildren in Tallinn was studied by a parental questionnaire ( n = 979) and skin‐prick tests ( n = 643), according to the International Study of Asthma and Allergies in Childhood. Data about BCG vaccinations and tuberculin tests were obtained from school records ( n = 723). Results: The prevalence of allergic symptoms and atopy was similar in children vaccinated during the first month of life and later. Positive tuberculin responses (≥5 mm) were inversely related to symptoms of asthma [odds ratio (OR) 0.10 (95% confidence interval 0.00–0.68) for exercise‐induced wheezing; OR 0.37 (0.12–0.99) for night cough], and eczema [OR 0.53 (0.28–0.98)] but not to atopy. However, among BCG‐revaccinated children, atopy tended to be more common in tuberculin responders, and the atopic children were significantly more likely to have a positive tuberculin response after the revaccination than would be predicted by their first test. Conclusions: We found no protective effect of early BCG vaccination against atopy in school age, although tuberculin responses and allergic symptoms were inversely related.
177. A Novel Class of Cationic Amphiphiles for Airway Gene Delivery
Authors: Keun-Sik Kim, Qun Li, Takeshi Suda, Dexi Liu
Journal: Molecular Therapy (2006)

A new class of cationic amphiphiles was synthesized and characterized for their transfection activity in mouse lung by intratracheal delivery. These cationic compounds, consisting of a backbone of the bis(2-hydroxy-3-alkiammonio)propyl methylamine with various alkyl chains (C12 to C18) linked to two amine groups, undergo temperature and concentration dependent transition from liposomes to micelles. They are highly soluble in water and readily form complexes with DNA, depending on the chain length of the alky group in the compounds.
Patent Foramen Ovale and Stroke Prevention—To Close or Not to Close
Authors: Allison M. Wolfe, Mim Ari
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Ephrin-B1 Controls the Columnar Distribution of Cortical Pyramidal Neurons by Restricting Their Tangential Migration
Authors: Jordane Dimidschstein, Lara Passante, Audrey Dufour, Jelle van den Ameele, Luca Tiberi, Tatyana Hrechdakian, Ralf Adams, Rüdiger Klein, Dieter Chichung Lie, Yves Jossin, Pierre Vanderhaeghen
Journal: Neuron (2013)
THE INFLUENCE OF MAERIAGE, PREGNANCY AND CHILDBIRTH ON ACNE VULGARIS
Authors: MARIA A. RATZER
Journal: British Journal of Dermatology (1964)

Journal Article THE INFLUENCE OF MAERIAGE, PREGNANCY AND CHILDBIRTH ON ACNE VULGARIS Get access MARIA A. RATZER, M.D. MARIA A. RATZER, M.D. Skin Department, Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 4, 1 April 1964, Pages 165–168, https://doi.org/10.1111/j.1365-2133.1964.tb14501.x Published: 01 April 1964