tbuckley/cabot-search huggingface dataset:
TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration
Authors: Chun-Chi Liang, Lauren M. Tanabe, Stephanie Jou, Frank Chi, William T. Dauer
Journal: Journal of Clinical Investigation (2014)

Lack of a preclinical model of primary dystonia that exhibits dystonic-like twisting movements has stymied identification of the cellular and molecular underpinnings of the disease. The classical familial form of primary dystonia is caused by the DYT1 (ΔE) mutation in TOR1A, which encodes torsinA, AAA+ ATPase resident in the lumen of the endoplasmic reticular/nuclear envelope. Here, we found that conditional deletion of Tor1a in the CNS (nestin-Cre Tor1aflox/–) or isolated CNS expression of DYT1 mutant torsinA (nestin-Cre Tor1aflox/ΔE) causes striking abnormal twisting movements. These animals developed perinuclear accumulation of ubiquitin and the E3 ubiquitin ligase HRD1 in discrete sensorimotor regions, followed by neurodegeneration that was substantially milder in nestin-Cre Tor1aflox/ΔE compared with nestin-Cre Tor1aflox/– animals. Similar to the neurodevelopmental onset of DYT1 dystonia in humans, the behavioral and histopathological abnormalities emerged and became fixed during CNS maturation in the murine models. Our results establish a genetic model of primary dystonia that is overtly symptomatic, and link torsinA hypofunction to neurodegeneration and abnormal twisting movements. These findings provide a cellular and molecular framework for how impaired torsinA function selectively disrupts neural circuits and raise the possibility that discrete foci of neurodegeneration may contribute to the pathogenesis of DYT1 dystonia.
Lazarus, Come Forth
Authors: Hilda Markey
Journal: New England Journal of Medicine (1961)

IN January, 1958, an intensive-treatment program was started in a unit of the Continued Treatment Service of the Veterans Administration Hospital in Bedford, Massachusetts, with no change in complement of personnel. The aim of the program was to help each patient develop to the highest level of adjustment possible in accordance with his capacity.The unit of 180 male patients was housed in a two-story building, with two wards on each floor. About 90 per cent of the cases were classified as schizophrenia, 2 or 3 as manic-depressive psychosis, and the remainder as chronic brain syndrome. As vacancies occurred they . . .
1150-150 Freehand and rotational transthoracic three-dimensional echocardiography improve the quantification of atrial septal defect size before percutaneous closure
Authors: Jaroslaw D Kasprzak, Michal Ciesielczyk, Pawel Dryzek, Piotr Lipiec, Andrzej Sysa, Michal Plewka, Jaroslaw Drozdz, Maria Krzeminska-Pakula
Journal: Journal of the American College of Cardiology (2004)
Deterioration of risk factors is not a major determinant of coronary events in depressive patients with acute myocardial infarction
Authors: Issei Shiotani, Hiroshi Sato, Hideyuki Sato, Kunihiro Kinjo, Daisaku Nakatani, Hiroya Mizuno, Eiji Hishida, Yozo Ohnishi, Seiki Nagata, Noritake Houki, Masatsugu Hori
Journal: Journal of the American College of Cardiology (2002)
Cost effectiveness of strategies to combat neuropsychiatric conditions in sub-Saharan Africa and South East Asia: mathematical modelling study
Authors: D. Chisholm, S. Saxena
Journal: BMJ (2012)

<b>Objective</b> To assess the comparative costs and effects of interventions to combat five neuropsychiatric conditions (schizophrenia, bipolar disorder, depression, epilepsy, and heavy alcohol use). <b>Design</b> Cost effectiveness analysis based on an epidemiological model. <b>Setting</b> Two epidemiologically defined World Health Organization sub-regions of the world: countries in sub-Saharan Africa with very high adult and high child mortality (AfrE); and countries in South East Asia with high adult and high child mortality (SearD). <b>Data sources</b> Published studies, costing databases. <b>Main outcome measures</b> Cost per capita and cost per disability adjusted life year (DALY) averted, expressed in international dollars ($Int) for the year 2005. <b>Results</b> Across 44 assessed intervention strategies for the five neuropsychiatric conditions, cost effectiveness values differed by as much as two orders of magnitude (from $Int100–250 to $Int10 000–25 000 for a year of healthy life gained). In both sub-regions, inpatient based treatment of schizophrenia with newer antipsychotic drugs was the most costly and least cost effective strategy. The most cost effective strategies in the African sub-region related to population based alcohol control, while in the South East Asian sub-region the most cost effective intervention was drug treatment of epilepsy in primary care. The cumulative cost per capita of the most cost effective set of interventions covering all five conditions was estimated at $Int4.90–5.70. This package comprises interventions for epilepsy (older first line antiepileptic drugs); depression (generically produced newer antidepressants and psychosocial treatment); bipolar disorder (mood stabiliser drug lithium); schizophrenia (neuroleptic antipsychotic drugs and psychosocial treatment); and heavy alcohol use (increased taxation and its enforcement, reduced access, and, in the African sub-region, advertising bans and brief advice to heavy drinkers in primary care). <b>Conclusions</b> Reallocation of resources to cost effective intervention strategies would increase health gain, save money and help implement much needed expansion of services for neuropsychiatric conditions in low resource settings.
Tyrosine Phosphatase SHP-1 in Oxidative Stress Involves in Mucin production from human bronchial epithelial cells
Authors: Y. Bae, M. Jang, T. Kim, K. Moon, C. Park, J. Lee, K. Lee, H. Moon, Z. Zhu, Y. Cho
Journal: Journal of Allergy and Clinical Immunology (2009)
Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays
Authors: Quan Li Zhen, Chun Xie, Tianfu Wu, Meggan Mackay, Cynthia Aranow, Chaim Putterman, Chandra Mohan
Journal: Journal of Clinical Investigation (2005)

Nephrophilic autoantibodies dominate the seroprofile in lupus, but their fine specificities remain ill defined. We constructed a multiplexed proteome microarray bearing about 30 antigens known to be expressed in the glomerular milieu and used it to study serum autoantibodies in lupus. Compared with normal serum, serum from B6.Sle1.lpr lupus mice (C57BL/6 mice homozygous for the NZM2410/NZW allele of Sle1 as well as the FAS defect) exhibited high levels of IgG and IgM antiglomerular as well as anti-double-stranded DNA/chromatin Abs and variable levels of Abs to alpha-actinin, aggrecan, collagen, entactin, fibrinogen, hemocyanin, heparan sulphate, laminin, myosin, proteoglycans, and histones. The use of these glomerular proteome arrays also revealed 5 distinct clusters of IgG autoreactivity in the sera of lupus patients. Whereas 2 of these IgG reactivity clusters (DNA/chromatin/glomeruli and laminin/myosin/Matrigel/vimentin/heparan sulphate) showed association with disease activity, the other 3 reactivity clusters (histones, vitronectin/collagen/chondroitin sulphate, and entactin/fibrinogen/hyaluronic acid) did not. Human lupus sera also displayed 2 distinct IgM autoantibody clusters, one reactive to DNA and the other apparently polyreactive. Interestingly, the presence of IgM polyreactivity in patient sera was associated with reduced disease severity. Hence, the glomerular proteome array promises to be a powerful analytical tool for uncovering novel autoantibody disease associations and for distinguishing patients at high risk for end-organ disease.
Mind Wide Open: Your Brain and the Neuroscience of Everyday Life
Authors: R. J. Hawley
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylactic intraaortic balloon pumping for acute myocardial infarction does not improve left ventricular function
Authors: Cindy L. Grines, Bruce R. Brodie, John J. Griffin, Bryan C. Donohue, C. Costantini, Carlos Balestrini, Gregg Stone, Thomas P. Wharton, Lloudmila Mitina, Mariann Graham, Denise E. Jones, Debra Sachs, William W. O'Neill
Journal: Journal of the American College of Cardiology (1996)
Increase in basal cell carcinoma incidence steepest in individuals with high socioeconomic status: results of a cancer registry study in the Netherlands
Authors: S. van Hattem, M.J. Aarts, W.J. Louwman, H.A.M. Neumann, J.W.W. Coebergh, C.W.N. Looman, T. Nijsten, E. de Vries
Journal: British Journal of Dermatology (2009)

Development of both basal cell carcinoma (BCC) and cutaneous malignant melanoma (MM) is associated with acute and intermittent sun exposure. In contrast to MM, the association between socioeconomic status (SES) and BCC is not well documented.To investigate the incidence of BCC according to SES, stratifying by age and tumour localization in a large population-based cohort. To assess changes over time in the distribution of the patients with BCC across the SES categories.All patients with a histologically confirmed first primary BCC (n = 27,027) diagnosed between 1988 and 2005 in the Southeast of The Netherlands were stratified by sex, age (25-44, 45-64 and > or = 65 years), period of diagnosis, SES category (based on income and value of housing) and localization of the BCC. Age-standardized BCC incidence rates were calculated for the year 2004 by SES category and localization. Ordinal regression was used to assess changes over time in the proportion of patients with BCC by sex, age and SES.For men in all age groups higher BCC incidence in the highest SES category was observed, which remained significant after stratification for tumour localization. For women a consistent relationship was found only in younger women (< 65 years) for truncal BCCs, which occurred more frequently in high SES groups. Between 1990 and 2004, the proportion of BCC patients with high SES increased (+6%) and the proportion with low SES decreased (-7%).High SES is associated with increased incidence of BCC among men. Our data suggest that BCC is changing from a disease of the poor to a disease of the rich.
Enhancement of Tetracycline Blood Levels
Authors: Calvin M. Kunin, Wilfred F. Jones, Maxwell Finland, Clare Wilcox, Ann Najarian
Journal: New England Journal of Medicine (1958)

FOUR different tetracycline preparations — namely, tetracycline phosphate complex,1 2 3 4 5 6 7 tetracycline base with sodium hexametaphosphate,2 , 4 , 5 , 7 8 9 tetracycline hydrochloride with citric acid4 , 5 , 9 and tetracycline hydrochloride with glucosamine hydrochloride10 , 11 — have been made available during the past few months. Each of these preparations has been reported as providing higher blood levels when compared with similar doses of tetracycline hydrochloride, and some of them have been reported as yielding higher levels than others.The difficulties in evaluating most of the published reports have been pointed out elsewhere.12 , 13 In particular, many of the comparisons have been made with capsules, some of which contained calcium compounds, and . . .
Tissue Doppler Imaging in the Estimation of Intracardiac Filling Pressure in Decompensated Patients With Advanced Systolic Heart Failure
Authors: Wilfried Mullens, Allen G. Borowski, Ronan J. Curtin, James D. Thomas, W.H. Tang
Journal: Circulation (2008)

Background— The ratio of early transmitral velocity to tissue Doppler mitral annular early diastolic velocity (E/Ea) has been correlated with pulmonary capillary wedge pressure (PCWP) in a wide variety of cardiac conditions. The objective of this study was to determine the reliability of mitral E/Ea for predicting PCWP in patients admitted for advanced decompensated heart failure. Methods and Results— Prospective consecutive patients with advanced decompensated heart failure (ejection fraction ≤30%, New York Heart Association class III to IV symptoms) underwent simultaneous echocardiographic and hemodynamic evaluation on admission and after 48 hours of intensive medical therapy. A total of 106 patients were included (mean age, 57±12 years; ejection fraction, 24±8%; PCWP, 21±7 mm Hg; mitral E/Ea ratio, 20±12). No correlation was found between mitral E/Ea ratio and PCWP, particularly in those with larger left ventricular volumes, more impaired cardiac indexes, and the presence of cardiac resynchronization therapy. Overall, the mitral E/Ea ratio was similar among patients with PCWP &gt;18 and ≤18 mm Hg, and sensitivity and specificity for mitral E/Ea ratio &gt;15 to identify a PCWP &gt;18 mm Hg were 66% and 50%, respectively. Contrary to prior reports, we did not observe any direct association between changes in PCWP and changes in mitral E/Ea ratio. Conclusion— In decompensated patients with advanced systolic heart failure, tissue Doppler–derived mitral E/Ea ratio may not be as reliable in predicting intracardiac filling pressures, particularly in those with larger LV volumes, more impaired cardiac indices, and the presence of cardiac resynchronization therapy.
Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells.
Authors: M A Barcinski, A S Rosenthal
Journal: The Journal of Experimental Medicine (1977)

T-cell DNA synthesis and T-helper cell function in response to isolated insulin chains and naturally occurring insulin variants was assessed in insulin immune guinea pigs. Two distinct antigenic determinants, recognized by T cells, were defined. One localized in the B chain and the other one constituted by amino acids A8, A9, and A10 of the insulin A-chain loop. Recognition of the B-chain determinant is under the control of Ir genes linked to the strain 13 major histocompatibility complex. This was shown by studying the response to isolated insulin B chain in F1(2 x 13) guinea pigs, as well as serologically defined backcrosses and outbred animals. Insulin recognition through the A-chain loop determinant is specific for strain 2 guinea pigs. These animals recognize this region of the molecule even when displaying different amino acid sequences. The strain differences observed in those antigenic sites eliciting T-cell recognition was not found at an antibody level. No differences could be detected in the ability of the different insulin variants to inhibit the binding of 125I-labeled pork insulin to strain 2 guinea pig anti-pork insulin or to strain 13 guinea pig anti-pork insulin.
Naloxane and Alcohol Intoxication
Authors: J. DUCOBU
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 April 1984Naloxane and Alcohol IntoxicationJ. DUCOBU, M.D.J. DUCOBU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-617_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent reports suggest that naloxone hydrochloride can reverse alcoholic coma (1, 2), whereas at least one paper does not report this effect (3). We report a prospective, double-blinded, randomised, placebo-controlled study of the clinical value of naloxone for reversing ethanol intoxication.We selected 19 consecutive unconscious patients with proven ethanol overdose. Eleven patients had pure ethanol intoxication, and 8 had ethanol and benzodiazepine or barbiturate intoxication. Toxicologic screening was done systematically. When the randomisation code was broken, 10 patients had been treated with 0.8 mg of intravenous naloxone and 8 with placebo. The alcohol values (mean ±...References1. LYONANTONY LJ. Reversal of alcoholic coma by naloxone. Ann Intern Med. 1982;96:464-5. LinkGoogle Scholar2. JEFFREYSVOLANTS DG. An investigation of the role of the specific opioid antagonist naloxone in clinical toxicology. Hum Toxicol. 1983;2:227-31. CrossrefMedlineGoogle Scholar3. NUOTTOPALVALAHDENRAWTA EEU. Naloxone failed to counteract heavy alcohol intoxication [Letter]. Lancet. 1983;2:167. CrossrefMedlineGoogle Scholar4. NABERSOBLEPICKAR DMD. Ethanol increases opioid activity in plasma of normal volunteers. Pharmacopsychiatria. 1981;14:160-1. CrossrefMedlineGoogle Scholar5. BADAWYEVANS AM. Naloxone in ethanol intoxication [Letter]. Ann Intern Med. 1983;98:672. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Centre Hospitalier de Tivoli 7100 La Louvière Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAmethystic agents influencing toxicodynamics of ethanolÉthanolEthanolPlasma concentrations of β-endorphin, adrenocorticotropic hormone, and cortisol in drinking and abstinent chronic alcoholicsThe effects of alcoholism on the hypothalamic-pituitary-adrenal axis: interaction with endogenous opioid peptidesIntoxicated Airline Pilots: A Case‐based Ethics ModelEthanol-Induced Increase in Endogenous Dopamine Release May Involve Endogenous OpiatesBasic and Clinical Studies on Serotonin, Alcohol, and AlcoholismGastric emptying in the acutely inebriated patientL'intoxication éthylique aiguë dans le Service d'Accueil et d'UrgenceConduite a tenir thérapeutique et surveillanceFocal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis studyPlasma β-endorphin levels in chronic alcoholicsAcute Ethanol Poisoning and the Ethanol Withdrawal SyndromePOSTER COMMUNICATIONS 1 April 1984Volume 100, Issue 4Page: 617-618KeywordsAlcoholicsAlcoholismAlcoholsComaEthanolIntoxication Issue Published: 1 April 1984 PDF DownloadLoading ...
The risk of gastrointestinal perforations in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the BSRBR-RA
Authors: Jakub Závada, Mark Lunt, Rebecca Davies, Audrey SL Low, Louise K Mercer, James B Galloway, Kath D Watson, Deborah P Symmons, Kimme L Hyrich
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To evaluate the risk of gastrointestinal perforation (GIP) in subjects with rheumatoid arthritis (RA) treated with antitumour necrosis factor (anti-TNF) therapy compared with non-biological disease-modifying antirheumatic drugs (nbDMARDs). <h3>Methods</h3> Using data from the British Society for Rheumatology Biologics Register, we compared the incidence of GIPs between 11 881 anti-TNF-treated and 3393 nbDMARD-treated RA patients using Cox regression modelling. Hazard ratios (HRs) with confidence intervals (CI) were calculated. Adjustment was made for potential confounders including current steroid use. The study covered the time period between 2001 and 2011. <h3>Results</h3> There were 42 (upper 20, lower 22) GI perforations: five in the nbDMARD cohort and 37 in the anti-TNF cohort. After adjustment, treatment with TNF antagonists was associated with an HR of 1.6 (95% CI 0.4 to 6.0) for all GIPs, 2.7 (95% CI 0.4 to 18.1) for lower GIPs and 0.9 (95% CI 0.1 to 5.8) for upper GIPs. Current use of steroids was the single most important predictor of GI perforation with an adjusted HR of 2.9 (95% CI 1.5 to 5.4), but this risk was confined to lower GIPs (HR 8.0, 95% CI 2.6 to 24.1). <h3>Conclusions</h3> We have not found a statistically significant association between anti-TNF treatment and the risk of GIP.
Carcinogenesis in Rats of Combined Ethylene Dibromide and Disulfiram
Authors: Harry B. Plotnick
Journal: JAMA (1978)

To the Editor.—  A study of the toxicity of inhaled ethylene dibromide (EDB; 1,2-dibromoethane), a widely used industrial chemical, is currently being performed for the National Institute for Occupational Safety and Health by the Midwest Research Institute (MRI), Kansas City, Mo. Male and female Sprague-Dawley rats are being exposed to EDB at the current US Occupational Standard of 20 ppm or to filtered air (controls) for seven hours a day, five days a week.  There are four groups of animals in the study, each group containing 48 male and 48 female rats. The group designations are as follows: (1) control/control—filtered air exposed, standard rat diet; (2) control/disulfiram—filtered air exposed, diet containing 0.05% disulfiram by weight; (3) EDB/control—20 ppm EDB, standard rat diet; and (4) EDB/disulfiram—20 ppm EDB, diet containing 0.05% disulfiram by weight.  Disulfiram was chosen as a potential modifier of toxicity because of its known effect as an enzyme
Observations upon ammonia absorption from the human ileum
Authors: J. D. Swales, M. Papadimitriou, O. M. Wrong
Journal: Gut (1973)

Experiments have been performed upon the absorption of ammonia and hydrazine from different solutions instilled into a human ileal sac with an exteriorized stoma. Ammonia and hydrazine absorption was greater from solutions of higher pH. It is concluded that non-ionic diffusion plays an important role in ammonia absorption from the human ileum.
Ethics and euthanasia Opinion polls not decisive
Authors: A Fergusson, R A Catterall
Journal: BMJ (1994)

Little information is available regarding the mechanisms involved in cytokine-induced synthetic function of human airway smooth muscle (ASM) cells. Here, we report that tumor necrosis factor receptor (TNFR) 1-induced p38 and p42/44 mitogen-activated protein kinase (MAPK) activation modulates tumor necrosis factor-α (TNFα)-mediated synthetic responses: expression of intercellular adhesion molecule-1 (ICAM-1) and secretion of interleukin (IL)-6 and the regulated-on-activation, normal T-cell expressed and secreted (RANTES) chemokine in human ASM cells. Pretreatment of ASM cells with SB203580, a p38 MAPK inhibitor, slightly enhanced TNFα-induced ICAM-1 expression in a dose-dependent manner but partially inhibited secretion of RANTES and IL-6. In contrast, PD98059, a p42/44 inhibitor, reduced ICAM-1 expression by 50% but had no effect on TNFα-induced RANTES or IL-6 secretion. SB203580 and PD98059 had little effect on TNFα-induced nuclear factor-κB (NF-κB) activation as determined in cells transfected with a NF-κB–luciferase reporter construct. We also found that agonistic antibodies specific for either TNFR1 or TNFR2 stimulated IL-6 and RANTES secretion and activated p38 and p42/44 MAPKs. In addition, both antibodies induced NF-κB-mediated gene transcription. Using receptor-specific blocking antibodies, we found that TNFR1 primarily regulates TNFα-induced IL-6 and RANTES secretion and activation of p38 and p42/44 MAPK pathways. Interestingly, we found that TNFR1 and TNFR2 are expressed differently on the cell surface of ASM cells. Our data suggest that despite the presence of functional TNFR2, TNFR1 associated with MAPK-dependent and -independent pathways is the primary signaling pathway involved in TNFα-induced synthetic functions in ASM cells.
Male patient with acute hepatitis E in Genoa, Italy: figatelli (pork liver sausage) as probable source of the infection
Authors: A.R. Garbuglia, A.I. Alessandrini, N. Pavio, S. Tessé, S. Grignolo, C. Viscoli, D. Lapa, M.R. Capobianchi
Journal: Clinical Microbiology and Infection (2014)