HLA Typing in Patients with Wegener Granulomatosis
Authors: Mary Frances Cotch, Anthony S. Fauci, Gary S. Hoffman
Journal: Annals of Internal Medicine (1995)

Letters15 April 1995HLA Typing in Patients with Wegener GranulomatosisMary Frances Cotch, Anthony S. Fauci, and Gary S. HoffmanMary Frances CotchResearch Triangle Institute, Center for Medical, Environmental and Energy, Rockville, MD 20852. National Institutes of Health, Bethesda, MD 20892. The Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this author, Anthony S. FauciResearch Triangle Institute, Center for Medical, Environmental and Energy, Rockville, MD 20852. National Institutes of Health, Bethesda, MD 20892. The Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this author, and Gary S. HoffmanResearch Triangle Institute, Center for Medical, Environmental and Energy, Rockville, MD 20852. National Institutes of Health, Bethesda, MD 20892. The Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-8-199504150-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:To investigate a potential genetic basis for Wegener granulomatosis, we screened 83 patients for human leukocyte antigen (HLA) A, B, and C, and DR-DQ markers and compared the frequencies of these phenotypes with those in 4039 normal persons screened for organ donation and 2163 normal persons randomly selected for histocompatibility testing. The results of chi-square analyses showed that B50 and DR9 phenotypes were statistically more likely to occur in patients with Wegener granulomatosis. In the two control groups, the frequency for the B50 phenotype was 1.5% and 2.2%, respectively, and the frequency for the DR9 phenotype was ...References1. Strimlan CV, Taswell HF, Kueppen F, DeRemee RA, McDonald TJ. HLA antigens of patients with Wegener's granulomatosis. Tissue Antigens. 1978; 11:129-31. Google Scholar2. Beigel A, Lehmann H, Westphal E. The spectrum of histocompatibility antigens (HLA) in Wegener's granulomatosis. Arch Otolaryngol. 1980; 233:157-60. Google Scholar3. Elkon KB, Sutherland DC, Rees AJ, Hughes GR, Batchelor JR. HLA antigen frequencies in systemic vasculitis: increase in HLA-DR2 in Wegener's granulomatosis. Arthritis Rheum. 1983; 26:102-5. Google Scholar4. Papiha SS, Murty GE, Ad'Hiah AH, Mains BT, Venning M. Association of Wegener's granulomatosis with HLA antigens and other geneticmarkers. Ann Rheum Dis. 1992; 51:246-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Mary Frances Cotch; Anthony S. Fauci; Gary S. HoffmanAffiliations: Research Triangle Institute, Center for Medical, Environmental and Energy, Rockville, MD 20852. National Institutes of Health, Bethesda, MD 20892. The Cleveland Clinic Foundation, Cleveland, OH 44195. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDistinct HLA and non‐HLA associations in different subtypes of ANCA‐associated vasculitides in North IndiaEarly Outcomes in Children With Antineutrophil Cytoplasmic Antibody-Associated VasculitisAntineutrophil Cytoplasmic Antibody Associated VasculitisAssociation of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 statusGenetic aspects of anti-neutrophil cytoplasmic antibody-associated vasculitisGenetic Susceptibility to ANCA-Associated Vasculitis: State of the ArtThe Molecular Biology and Treatment of Systemic Vasculitis in ChildrenRisks and relative risks of Wegener's granulomatosis among close relatives of patients with the diseaseSmall- and medium-vessel primary vasculitisOn the Wegener granulomatosis associated region on chromosome 6p21.3Translating basic science into patient therapy for ANCA-associated small vessel vasculitisComplex genetics of Wegener granulomatosisPathogenesis: immunogenetic factorsVasculitisHLA and Systemic Vasculitides, Systemic Lupus Erythematosus and Sjögren's Syndrome 15 April 1995Volume 122, Issue 8Page: 635KeywordsGenetic diseasesGenetic predispositionGenetic testingHistocompatibilityHuman leukocyte antigenPhenotypesWegener granulomatosis ePublished: 15 August 2000 Issue Published: 15 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...