tbuckley/cabot-search huggingface dataset:
Maharishi Ayur-Veda: Guru's Marketing Scheme Promises the World Eternal 'Perfect Health'
Authors: Andrew A. Skolnick
Journal: JAMA (1991)

IF THE CLAIMS of Maharishi Mahesh Yogi prove true, those who follow him soon will be blessed with eternal youth, "perfect health," and the "strength of an elephant." They will be able to "walk through walls," make themselves "invisible," and "fly through the air" without the benefit of machines. In addition, there will be no more war or crime. Automobile accidents will be a thing of the past, and even the weather will have to obey their collective consciousness. Such are the widely promoted claims of the Transcendental Meditation (TM) movement and Maharishi Ayur-Veda, some of which were presented by authors Deepak Chopra, MD, Hari M. Sharma, MD, FRCPC, and Brihaspati Dev Triguna, in their "Letter From New Delhi" ("Maharishi Ayur-Veda: Modern Insights Into Ancient Medicine,"<i>JAMA</i>. 1991;265:2633-2637). According to a number of experts on religious cults, Maharishi Mahesh Yogi, the Hindu swami from India, began his rise to fame
Abstract A18: Time-resolved luminescence detection of spleen tyrosine kinase activity through terbium sensitization
Authors: Andrew M. Lipchik, Laurie L. Parker
Journal: Cancer Research (2012)

Abstract Spleen tyrosine kinase (Syk) plays an important role in multiple B-cell signaling pathways. Deregulation of Syk activity has been shown to contribute to various malignant B-cell disorders including non-Hodgkin's lymphomas and chronic lymphocytic leukemia making Syk a potential drug target. However, monitoring the therapeutic response of Syk can be convoluted by the phosphorylation state of Syk or its downstream targets not always correlating with its enzymatic activity. Currently, there are few methods available for monitoring Syk activity directly. Peptide-based approaches allow for direct detection of kinase activity circumventing the need to assess phosphorylation status of the kinase. Peptides have been applied to the detection of Syk activity in the past using fluorescent amino acids, but these approaches have not yet reached an optimized degree of specificity or signal to noise. Chelation with terbium has been used to achieve phosphorylation-dependent luminescence with substrate peptides. Terbium is a hard acid giving it preferred coordination with negatively charged species such as phosphate, carboxylate and carbonyl groups. Terbium as a luminescent probe for detection of phosphorylation offers several advantages over organic fluorophores. Terbium has unique optical properties including large stokes shifts, long luminescent lifetimes, and narrow emission bands. Recently, we have developed a Syk specific artificial substrate peptide (SAStide) consisting of an acidic motif with a central tyrosine capable of detecting intracellular Syk activity. We have characterized SAStide's ability to chelate terbium and sensitize terbium luminescence in a phosphorylation-dependent manner. Here we present the use of time-resolved luminescence through terbium sensitization for detection of Syk activity and inhibition using SAStide in vitro. Citation Format: Andrew M. Lipchik, Laurie L. Parker. Time-resolved luminescence detection of spleen tyrosine kinase activity through terbium sensitization [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr A18.
Pharmaceutical research and development: what do we get for all that money?
Authors: D. W. Light, J. R. Lexchin
Journal: BMJ (2012)

Data indicate that the widely touted "innovation crisis" in pharmaceuticals is a myth. The real innovation crisis, say <b>Donald Light</b> and <b>Joel Lexchin</b>, stems from current incentives that reward companies for developing large numbers of new drugs with few clinical advantages over existing ones
High-Density Lipoprotein Deficiency and Dyslipoproteinemia Associated With Venous Thrombosis in Men
Authors: Hiroshi Deguchi, Natalie M. Pecheniuk, Darlene J. Elias, Patricia M. Averell, John H. Griffin
Journal: Circulation (2005)

Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients.We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoproteins AI and B in blood samples from 49 male venous thrombosis patients and matched controls aged <55 years. Venous thrombosis patients had significantly lower levels of HDL particles, large HDL particles, HDL cholesterol, and apolipoprotein AI and significantly higher levels of LDL particles and small LDL particles. The quartile-based odds ratios for decreased HDL particle and apolipoprotein AI levels in patients compared with controls were 6.5 and 6.0 (95% CI, 2.3 to 19 and 2.1 to 17), respectively. Odds ratios for apolipoprotein B/apolipoprotein AI ratio and LDL cholesterol/HDL cholesterol ratio were 6.3 and 2.7 (95% CI, 1.9 to 21 and 1.1 to 6.5), respectively. When polymorphisms in genes for hepatic lipase, endothelial lipase, and cholesteryl ester transfer protein were analyzed, patients differed significantly from controls in the allelic frequency for the TaqI B1/B2 polymorphism in cholesteryl ester transfer protein, consistent with the observed pattern of lower HDL and higher LDL.Venous thrombosis in men aged <55 years old is associated with dyslipoproteinemia involving lower levels of HDL particles, elevated levels of small LDL particles, and an elevated ratio of apolipoprotein B/apolipoprotein AI. This dyslipoproteinemia seems associated with a related cholesteryl ester transfer protein genotype difference.
Anergy, Zinc Deficiency, and Decreased Nucleoside Phosphorylase Activity in Patients with Sickle Cell Anemia
Authors: OSCAR F. BALLESTER
Journal: Annals of Internal Medicine (1983)

Cell-mediated immunity was evaluated in 26 patients with sickle cell anemia using skin tests for delayed hypersensitivity reactions. Patients with impaired delayed hypersensitivity reactions had lower zinc levels in plasma, erythrocytes, and neutrophils than patients with normal delayed hypersensitivity reactions or controls. The activity of nucleoside phosphorylase, an enzyme essential for T-lymphocyte function, was significantly lower in zinc-deficient patients with anergic sickle cell anemia. We conclude that zinc deficiency in patients with sickle cell anemia is associated with impaired delayed hypersensitivity. Decreased activity of nucleoside phosphorylase may be partially responsible for lymphocyte dysfunction in these patients.
Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis
Authors: J. A C Sterne, M. Egger, G. D. Smith
Journal: BMJ (2001)

<h3>Abstract</h3> <h3>Objective</h3> Obesity drives significant changes in adipose tissue that precede development of tissue and systemic insulin resistance. Immune cell infiltration and inflammation are known contributors to these changes but there is limited understanding of their spatial context tissue-wide. We sought to identify spatial patterning in epididymal adipose tissue immune cells in a time course of diet-induced obesity in mice. <h3>Methods</h3> Using spatial transcriptomics and single-cell RNA-sequencing, we identified dominant cell type signatures preserved in their anatomical context, quantified gene expression patterns at spots throughout adipose tissue, performed cell type network analysis, and investigated ligand-receptor colocalization. <h3>Results</h3> Our data support increased innate immune cells, including macrophages, monocytes, and innate lymphoid cells with tissue-wide interspersion, and dampened adaptive immune cell signatures with obesity. Network analysis identified increased heterogeneity in all major immune cell types, consistent with increased subtypes. To capture tissue dynamics at obesity onset, we draw on mathematical principles from linear algebra and spectral graph theory and provide a framework for better understanding cell cooperation toward emergence of multicellular tissue function. <h3>Conclusion</h3> The culmination of these analyses revealed a widespread paradigm shift in ligand-receptor activity with near-exclusive macrophage-macrophage or monocyte-macrophage interactions at crown-like structures across adipose tissue in early obesity. <h3>Highlights</h3> Spatial transcriptomics shows innate immune cell dominance in obese adipose tissue Increased monocyte signaling accompanies infiltration in obesity Pre-crown-like niches precede crown-like structure formation Influential monocyte-macrophage ligand-receptor pairs emerge at crown-like niches
Maintenynce treatment with cyclosporin in psoriasis
Authors: D. Ioannides, G. Mattheou-Vakali, E. Lazaridou, K. Batsios, D. Panagiotidou, A. Minas
Journal: British Journal of Dermatology (1997)

Journal Article Maintenynce treatment with cyclosporin in psoriasis Get access D. Ioannides, D. Ioannides Department of Dermatology, Aristotle University Medical School, 51 Chalkidikis Street, 546 43, Thessaloniki, Greece Search for other works by this author on: Oxford Academic Google Scholar G. Mattheou‐Vakali, G. Mattheou‐Vakali Department of Dermatology, Aristotle University Medical School, 51 Chalkidikis Street, 546 43, Thessaloniki, Greece Search for other works by this author on: Oxford Academic Google Scholar E. Lazaridou, E. Lazaridou Department of Dermatology, Aristotle University Medical School, 51 Chalkidikis Street, 546 43, Thessaloniki, Greece Search for other works by this author on: Oxford Academic Google Scholar K. Batsios, K. Batsios Department of Dermatology, Aristotle University Medical School, 51 Chalkidikis Street, 546 43, Thessaloniki, Greece Search for other works by this author on: Oxford Academic Google Scholar D. Panagiotidou, D. Panagiotidou Department of Dermatology, Aristotle University Medical School, 51 Chalkidikis Street, 546 43, Thessaloniki, Greece Search for other works by this author on: Oxford Academic Google Scholar A. Minas A. Minas Department of Dermatology, Aristotle University Medical School, 51 Chalkidikis Street, 546 43, Thessaloniki, Greece Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 3, 1 March 1997, Pages 470–471, https://doi.org/10.1111/j.1365-2133.1997.tb14975.x Published: 01 March 1997
Synchronization of Plasmapheresis and Pulse Cyclophosphamide in Severe Systemic Lupus Erythematosus
Authors: Johann O. Schroeder, Hans H. Euler, Helmut Löffler
Journal: Annals of Internal Medicine (1987)

Two patients with severe systemic lupus erythematosus, who had not responded to conventional therapy, were treated with plasmapheresis and subsequent pulse cyclophosphamide. This approach uses the plasmapheresis-induced proliferation of pathogenic clones for partial clonal deletion by giving large doses of cytotoxic drugs during the assumed period of increased B-cell vulnerability. Both patients had a rapid and distinct improvement in clinical symptoms and laboratory parameters, including the control of a life-threatening case of lupus pneumonitis. Their conditions were stabilized by giving low-dose cyclophosphamide for the next 6 months. At 14-month follow-up, there were no clinical signs of relapse.
Effect of stanozolol on itching in primary biliary cirrhosis
Authors: R P Walt, T K Daneshmend, I W Fellows, P J Toghill
Journal: BMJ (1988)

related complex present diagnostic difficulties.The lymphadenopathy in this group may result from a treatable infection or neoplasm.To our knowledge these are the first reported cases in which ultrasound guided percutaneous biopsy has been done in such patients.We performed Tru-Cut biopsy rather than fine needle aspiration because this technique is capable of yielding a tissue specific diagnosis so that lymphomas may be characterised by their nodal architecture and immunohistological features.Percutaneous ultrasound guided biopsy is a simple method of obtaining tissue in patients with symptoms resulting from infection with HIV.It may remove the need for laparotomy, which has many disadvantages, including the use of considerable resources to provide appropriate precautions for the larger number of staff at risk of contact with infected blood.With this technique a skilled operator can achieve millimetric precision in placing the biopsy needle.In our experience of over 200 abdominal biopsies it is a safe technique even when the needle crosses bowel or includes bowel wall in the biopsy specimen (unpublished data).Furthermore, it is cheap and puts only the operator at risk of needlestick injury.
TCT-351 Predictors of Contrast Induced Nephropathy in Patients with Chronic Kidney Disease after Percutaneous Coronary Intervention
Authors: Ji-Hwan Kim, Seung-Hyuk Choi, Jin-Ho Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, Kyung Pyo Hong, Sang Hoon Lee, Jeong Euy Park, Young Bin Song, Jeong Hoon Yang
Journal: Journal of the American College of Cardiology (2013)
Photosensitivity Disease: Principles of Diagnosis and Treatment
Authors: Andrew P. Lazar
Journal: JAMA (1989)

When two leaders in the field of photobiology collaborate, one would expect an outstanding textbook, and, fortunately, Drs Bicker and Harber don't disappoint. From the preface in which they target their audience—dermatologists, pediatricians, internists, and family practitioners—to their large color atlas of common and not-so-common clinical diseases, this text offers important detailed information to the clinician and investigator. The book is divided into five sections. A brief introduction on the sun's role in history and mythology acts as a gentle bridge into the second section on the physics of radiant energy. Third is a section dealing with the therapeutic effects of radiation ranging from psoralen—ultraviolet-A range (PUVA) light (for psoriasis and cutaneous T-cell lymphoma) to phototherapy (for neonatal jaundice). This part is very up to date as it includes information such as the new liquid formulation of psoralen. The fourth and largest part of the book covers the diagnosis and
&lt;emph type="ital"&gt;Artist's Wife and Son&lt;/emph&gt;
Authors: M. Therese Southgate
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gluteal injections in increasingly obese population: Essential considerations for intramuscular injections
Authors: Saurabh Rai, Nidhi Nandan
Journal: BMJ (2006)

EDITOR—We agree with Nisbet that standard available needles may be inappropriate for gluteal intramuscular injections, especially when the incidence of obesity is increasing.1 However, his paper seems to exaggerate the problem.

Firstly, there are other preferred sites for intramuscular injections—for example, the mid-deltoid, rectus femoris, and vastus lateralis.2 Simpler clinical variables such as the weight of …
DEATH FROM TRANSFUSION OF PLASMA
Authors: Frank Mayner
Journal: JAMA (1941)

Reports of deaths due entirely to transfusion of whole blood are fairly rare. Reports of deaths due entirely to transfusion of plasma are still more rare. I have been unable to find any report of a fatality due to plasma transfusion in the English literature between the years 1927 and 1940. The lack of such reports may be explained by the only too recent enthusiasm over and use of transfusions of plasma. <h3>REPORT OF CASE</h3> A boy aged 4 years entered the hospital on July 31, 1940 because of severe edema. He had been perfectly well until one week before entry, when he acquired a cold the only manifestation of which was a running nose. He did not have a cough, sore throat, rash, articular pains, dyspnea or pains in the chest. Four days before entry he had edema of the ankles which gradually became generalized. One day before entry
The Antioxidant Vitamins and Cardiovascular Disease: A Critical Review of Epidemiologic and Clinical Trial Data
Authors: Prabhat Jha
Journal: Annals of Internal Medicine (1995)

Purpose: To review prospective epidemiologic studies and randomized trials regarding the role of antioxidant vitamins (vitamins E and C and β-carotene) in the prevention of cardiovascular disease, with emphasis on differences in results obtained by these two types of studies. Data Sources: Computerized and manual searches of the literature on antioxidant vitamins and cardiovascular disease. Study Selection: Prospective epidemiologic studies and randomized trials that included 100 or more participants and provided quantified estimates of antioxidant vitamin intake. Data Synthesis: Comparisons of relative risk reductions (RRR) across observational studies and randomized trials, including assessment of dose-response relations. Results: All three large epidemiologic cohort studies of vitamin E noted that high-level vitamin E intake or supplementation was associated with a significant reduction in cardiovascular disease (RRR range, 31% to 65%), as measured by various fatal and nonfatal cardiovascular end points. To obtain these reductions, vitamin E supplementation must last at least 2 years. Less consistent reductions were seen in studies of β-carotene (RRR range, −2% to 46%) and vitamin C (RRR range, −25% to 51%). Considerable biases in observational studies, such as different health behaviors of persons using antioxidants, may account for the observed benefit. By contrast, none of the completed randomized trials showed any clear reduction in cardiovascular disease with vitamin E, vitamin C, or β-carotene supplementation. The trials were not specifically designed to assess cardiovascular disease, did not provide data on nonfatal cardiovascular end points, may have had insufficient treatment durations, and used suboptimal vitamin E doses. The completed trials were of adequate size to indicate that the true therapeutic benefit of vitamin E and other antioxidants in reducing fatal cardiovascular disease (a survival benefit as long as 5 years) is probably more modest than the epidemiologic data suggest. Conclusion: The epidemiologic data suggest that antioxidant vitamins reduce cardiovascular disease, with the clearest effect for vitamin E; however, completed randomized trials do not support this finding. Much of this controversy should be resolved by the ongoing large-scale and long-term randomized trials designed specifically to evaluate effects on cardiovascular disease.
p53-Mediated Growth Suppression in Response to Nutlin-3 in Cyclin D1–Transformed Cells Occurs Independently of p21
Authors: Charlene E. Kan, John T. Patton, George R. Stark, Mark W. Jackson
Journal: Cancer Research (2007)

Interaction of cyclin D1 with cyclin-dependent kinases (CDK) results in the hyperphosphorylation of the RB family of proteins, thereby inactivating the tumor-suppressive function of RB. Our previous findings suggest that constitutive cyclin D1/CDK activity inhibits p53-mediated gene repression by preventing the appropriate regulation of CDK activity by the CDK inhibitor p21, a transcriptional target of p53. To study the role of cyclin D1 in driving human mammary cell transformation, we expressed a constitutively active cyclin D1-CDK fusion protein (D1/CDK) in immortalized human mammary epithelial cells. D1/CDK-expressing human mammary epithelial cells grew anchorage-independently in the presence of wild-type p53, consistent with the idea that D1/CDK disrupts downstream p53 signaling. Using this transformation model, we examined the sensitivity of the D1/CDK-expressing cells to Nutlin-3, an HDM2 antagonist that activates p53. Surprisingly, treatment of D1/CDK-transformed cells with Nutlin-3 prevented their anchorage-independent growth. The Nutlin-3-induced growth arrest was enforced in D1/CDK-expressing cells despite the presence of hyperphosphorylated RB implicating a p53-dependent, RB-independent mechanism for growth suppression. Further analysis identified that CDC2 and cyclin B1, key cell cycle regulators, were stably down-regulated following p53 stabilization by Nutlin-3, consistent with direct interaction between p53 and the CDC2 and cyclin B1 promoters, leading to the repression of transcription by methylation. In contrast to D1/CDK expression, direct inactivation of p53 resulted in no repression of CDC2 and no cell cycle arrest. We conclude that induction of p53 by Nutlin-3 is a viable therapeutic strategy in cancers with constitutive CDK signaling due to the direct repression of specific p53 target genes.
Migration of Foreign Bodies.
Authors: D. W. Beard
Journal: JAMA (1889)

<h3>Dear Sir:</h3> —The Journalfor January 19 contains a notice of the " Migration of a Needle. " The strange coincidence of reading about this case, and having passed through some little experience coming under the same head, I take pleasure in presenting the facts in the case for the information of your readers. The literature on foreign bodies found in all parts of the body is so profuse and general, that it necessarily requires something more than the ordinary daily routine of cases to be of sufficient interest to place the facts upon the pages of some medical journal. The history of cases is generally shrouded in doubt and uncertainty. It is always well to listen to the details, and then digest the facts. One case of an ordinary pin escaped the closest examination in the throat of a woman for<i>eleven years</i>. The case was subjected to repeated and
Clinical Implications of Lactic Dehydrogenase Activity in Sputum
Authors: Ida Levine
Journal: JAMA (1969)

Lactic dehydrogenase (LDH) activity is present in sputum. This activity is altered in an inconstant fashion when the sputum is stored; it is altered in a constant fashion when propylene glycol-saline inhalations are used for cough induction. With worsening of bronchopulmonary disease there occurs both an increase in total LDH activity and the appearance of or an increase in the electrophoretically faster isoenzyme fractions; with improvement of the condition the reverse is seen. The isoenzyme pattern is the more precise reflection of the patient's status.