tbuckley/cabot-search huggingface dataset:
Specificity in a global array is only one possibility
Authors: Eric L. Amazeen, Guy C. Van Orden
Journal: Behavioral and Brain Sciences (2004)

The suggestion of seeking specificity in a higher-order array is attractive, but Stoffregen &amp; Bardy (S&amp;B) fail to provide a compelling empirical basis to their claim that specificity exists solely in the global array. Using the example of relative motion, the alternate hypotheses that must be considered are presented.
Microspheres for targeting drugs to specific body sites
Authors: S.S. Davis, L. Ilium, S.M. Moghimi, M.C. Davies, C.J.H. Porter, I.S. Muir, A. Brindley, N.M. Christy, M.E. Norman, P. Williams, S.E. Dunn
Journal: Journal of Controlled Release (1993)
Leukemia in Workers Exposed to Ethylene Oxide
Authors: Christer Hogstedt
Journal: JAMA (1979)

Ethylene oxide, a gaseous sterilant extensively used within health care facilities, is known to be a mutagen in bacteria and in human lymphocytes. The Environmental Protection Agency as well as the National Institue of Occupational Safety and Health have recently stipulated certain conditions for the use of ethylene oxide despite the lack of case reports or epidemiologic studies concerning carcinogenicity. We report three cases of leukemia that occurred between 1972 and 1977 in a relatively small group of Swedish workers exposed to ethylene oxide. According to national statistics, 0.2 cases of leukemia would have been expected. The time-weighted average ethylene oxide concentration was 20+/-10 ppm.
Sedation With Dexmedetomidine vs Lorazepam in Mechanically Ventilated Patients
Authors: Jeffrey F. Barletta, John W. Devlin
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN INQUIRY INTO THE STRUCTURAL CONDITIONS AFFECTING FLUID TRANSPORT IN THE INTERSTITIAL TISSUE OF THE SKIN
Authors: Philip D. McMaster
Journal: The Journal of Experimental Medicine (1941)

With the aim of determining the structural conditions which affect fluid movement in the cutaneous connective tissue of mice, various test fluids were brought into contact with it under conditions such that neither blood vessels nor lymphatics were directly entered. Locke's solution, mouse serum, and a mixture of Locke's solution with a dye which causes edema were all employed. At atmospheric pressure, Locke's solution entered the tissues intermittently. When subjected to very low pressures it continued to enter the skin intermittently and at approximately the same rate. At pressures above 4.5 cm. of water, however, the flow became continuous but it did not increase in rate significantly until pressures of about 8.5 cm. were employed. There was no relationship between the rate of flow and the pressure employed. At a pressure of about 8.5 cm. the resistance of the tissues seemed to give way abruptly as if the formed elements had been separated. This has been termed the "breaking point." After it had been reached each further increase of pressure produced a proportionately greater inflow. Under the conditions of our experiments, the dye-Locke"s solution and also the homologous serum failed to enter the tissues at atmospheric pressure. It was necessary to subject these fluids to pressure to force them into the skin at the same rate at which the Locke's solution entered it spontaneously. Under these circumstances the dye-Locke's solution and the serum entered the skin continuously, not intermittently like the plain Locke's solution. As the pressure was gradually raised, no significant increase of flow into the tissues occurred until a point was reached, on the average 8.5 cm. of water, at which fluid suddenly began to enter very rapidly. This point, the "breaking point" already mentioned, was reached at the same pressure irrespective of the character of the fluid employed, showing that the phenomenon was produced by the fluid bulk. Once it had been attained, further increases in pressure caused proportionately greater inflow of fluid. The circulation had nothing to do with the phenomenon, for it occurred in the skin of dead mice." The findings indicate that under normal circumstances the movement of fluid in the interstitial tissue does not take place as though in preexisting channels. The experiments confirm previous observations from this laboratory (13, 14) that in normal skin tissue the state of affairs is such that fluid cannot flow freely. However, when fluid is introduced into the skin under pressure spaces are forcibly opened up. Inflammatory edema in the skin changed the phenomena of fluid entrance into it under pressure. The reason is that there then occurred a separation of the formed elements and the interstitial fluid moved as in preformed channels. Even when very low pressures were employed (3.0 to 7.0 cm. of water), there appeared usually a linear relationship between the pressure and the rate of flow.
Histamine H1 receptors on adherent rheumatoid synovial cells in culture: demonstration by radioligand binding and inhibition of histamine-stimulated prostaglandin E production by histamine H1 antagonists.
Authors: D J Taylor, D E Woolley
Journal: Annals of the Rheumatic Diseases (1987)

Histamine H1 receptors have been demonstrated on adherent rheumatoid synovial cells using biochemical and radioligand binding assays in vitro. The addition of histamine (17.8 mumol/l) to nine primary cultures of adherent rheumatoid synovial cells resulted in a two- to 21-fold increase in the production of prostaglandin E (PGE). This increase was inhibited by three H1 receptor antagonists (mepyramine, tripelennamine, and chlorpheniramine) in a dose related manner at concentrations below 10(-6) mol/l. Competitive binding assays with [3H]mepyramine gave ED50 values of approximately 10(-5) mol/l for the three H1 antagonists. H2 receptor antagonists (cimetidine and ranitidine) did not inhibit the histamine induced increase in PGE and did not compete effectively with the binding of H1 antagonists.
Presidential Address on the Progress of Laryngology
Authors: M. Mackenzie
Journal: BMJ (1888)

THE BRITZSH MBDICAL JO(RNAL tNov.17, 188&old Cfesarean section, and the mother died in every case.In a fourth case, seven years ago, I did exactly wlhat Sanger claits as a new operation, and 1 removed the appendages to prevent future impregnation, but the patient died. 1 put I these deaths down to the fatal influence of the " puerperal condition," but it is clear that that explanation is nonsense, for I have now done four operations on the principle laid down by Plrofessor Porro, and all the mothers have recovered, and the clhildren have all lived.The operation I perform is certainly not l'orro's operation, for I have altered nearly every detail; but the (liscovery of the new prin- ciple-tlhat of removing the uterus to save the mother from the fatal effects of suppitrative metritis, andl the possibility of having the same trouble over again-is the credit of my friend ProfessorPorro.I prefer to give the operation the name of no particular person, because men's names attached to operations are always productive of misunderstandings, quarrels, and confusion.I in- dicate the principle by calling it"amputation of the pregnant uterus," every word of this term being fact, and not theory.Mortality Analysis of Series.Cases.Deathis.Niortality. of 8previous per ceiit.per c-ent.Exploratory Incisions ... ... ... -3 2 :3.7 2.1 Cystoma parovarian ... ... ... 21 1) of one ovary ... ... ... 1.58 6 3.3 8.1 of both ovaries ... ... 78 2 .Enucleation of cysts of broad ligament... 12 0 Removal of appendages for mvoma ... 148 3 2.03 7.0 Removal of appendages for iniHammatory 3 diseases ... ... VM Y 3.4*2 5.Removal of appendages for deformity ... 2 0 0.0 0.0 Hysterectomy ... ...
More About DDT
Authors: Charles F. Wurster
Journal: JAMA (1975)

To the Editor.—  Thomas H. Jukes' extolling of DDT, while belittling its liabilities (229:571, 1974) might have made sense 20 years ago, but not today.  After seven months of comprehensive hearings, the Environmental Protection Agency (EPA) concluded that any benefits were greatly outweighed by the costs, and DDT was therefore banned at the end of 1972. 1,2 The decision, in no way political, as Jukes would have us believe, was upheld by the second highest court in the land, which ruled that it was based on substantial evidence.  Jukes overlooked or misjudged all important elements of the EPA decision. The hazard of cancer was among the most important. Jukes stated, I think it is unlikely that DDT is carcinogenic for human beings. Authorities on chemical carcinogenesis, including two from the National Cancer Institute, testified otherwise. They labeled DDT a cancer hazard for man because it caused tumors in laboratory animals.
Echocardiographic evaluation of the Valsalva Maneuver in healthy subjects and patients with and without heart failure.
Authors: A F Parisi, J J Harrington, J Askenazi, R C Pratt, K M McIntyre
Journal: Circulation (1976)

The Valsalva maneuver was evaluated by echocardiography in three groups: A) 10 normal volunteers, B) 10 patients with no history of heart failure and normal ejection fractions, and C) 10 patients with heart failure and depressed ejection fractions. Groups A and B had a significant fall in left ventricular internal dimensions and calculated stroke volume by end strain which returned rapidly to baseline in recovery without significant overshoot. Arterial pressure showed a signoidal strain pattern with a normal overshoot in early recovery in all group B patients. In group C ventricular dimensions did not diminish during strain; arterial pressures showed a "square wave" pressure elevation during strain without an overshoot in recovery. Echocardiography allows a new approach to evaluate further the left ventricular response to the Valsalva maneuver. Patients with severely depressed ejection fractions, unlike those with normal ventricular function, are unable to alter stroke output in response to acutely increased intrathoracic pressure. A square wave pressure response is a likely consequence of a fixed stroke output during the strain maneuver.
Dysregulation of toll‐like receptor‐2 (TLR‐2)‐induced effects in monocytes from patients with atopic dermatitis: impact of the TLR‐2 R753Q polymorphism
Authors: M. Niebuhr, J. Langnickel, C. Draing, H. Renz, A. Kapp, T. Werfel
Journal: Allergy (2008)

Background: Atopic dermatitis (AD) is often complicated by an enhanced susceptibility to bacterial skin infections, especially with Staphylococcus aureus . Toll‐like receptors (TLR), especially TLR‐2 recognizes cell wall components of S. aureus , e.g. lipoteichoic acid (LTA) and peptidoglycan (PGN). A heterozygous TLR‐2 R753Q polymorphism occurs in a frequency of 11.5% in adult AD patients and has been shown to be associated with a severe phenotype of AD. Methods: The aim of this study was to investigate the impact of TLR‐2 agonists (LTA, PGN and Pam3Cys) on cytokine production in human monocytes from AD patients with the TLR‐2 R753Q polymorphism compared with that of AD patients with ‘wild type’ TLR‐2 and control individuals to elucidate the functional role of the TLR‐2 R753Q polymorphism. Results: Monocytes from AD patients with the TLR‐2 R753Q mutation produced significantly more IL‐6 and IL‐12 compared with that of AD patients with nonmutated TLR‐2 upon stimulation with TLR‐2 agonists. Conclusion: We show for the first time functional differences in TLR‐2 responsiveness of monocytes from AD patients with the TLR‐2 R753Q mutation compared with wild type AD patients in a ligand‐dependent manner. Clinical implication: Our data support the emerging concept that AD patients have a dysbalance in innate and aquired immunity. TLR‐2 may be essential in the pathogenesis and maintenance of AD and may be involved in the enhanced susceptibility to skin infections with S. aureus and in a higher inflammatory response in patients with AD carrying the TLR‐2 polymorphism.
Public Health Strategies for Pandemic Influenza
Authors: Lawrence Gostin
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Popular, Yes, But Jury Still Out on Apnea Surgery
Authors: Chris Anne Raymond
Journal: JAMA (1986)

SINCE 1981, when Japanese surgeon Shiro Fujita, MD, and colleagues described their version of the procedure, uvulopalatopharyngoplasty (UPPP) has become an increasingly popular—but far from universally accepted—option for treating patients who suffer from snoring and/or severe obstructive sleep apnea (<i>JAMA</i>[MEDICAL NEWS] 1985;254:1275-1284). The National Center for Health Statistics in Hyattsville, Md, estimates that 5000 people underwent this type of surgery during 1983 and 1984. The charge for the surgery itself varies from $1000 to $2000 across the country, according to one surgeon familiar with the procedure; this does not include the cost of hospitalization for up to three days or other charges. Surgeons using this procedure report widely different success rates, ranging from 23% to 75%. At the Triological Society Spring Meeting in Palm Beach, Fla, surgeons from across the country tried to assess the meaning of such disparate results. One conclusion, noted by Roger L. Crumley, MD, a
Republican leaders scramble to clarify positions on vaccination
Authors: M. McCarthy
Journal: BMJ (2015)

Republican leaders scrambled this week to clarify their positions on vaccination after two of their party’s potential US presidential contenders made statements that seemed to support the position that vaccination should be voluntary.

First, New Jersey’s governor, Chris Christie, who was traveling in the United Kingdom on a trade mission, said on Monday 2 February that although he had had his children vaccinated, “I also understand that parents need to have some measure of choice in things as well. So that’s the balance that the government has to decide.”

The comment, coming amid a measles outbreak in the US that has grown to more than 100 cases,1 caused a stir. Health officials blame the outbreak on the large …
Complete Genome Sequences of Rat and Mouse Segmented Filamentous Bacteria, a Potent Inducer of Th17 Cell Differentiation
Authors: Tulika Prakash, Kenshiro Oshima, Hidetoshi Morita, Shinji Fukuda, Akemi Imaoka, Naveen Kumar, Vineet K. Sharma, Seok-Won Kim, Mahoko Takahashi, Naruya Saitou, Todd D. Taylor, Hiroshi Ohno, Yoshinori Umesaki, Masahira Hattori
Journal: Cell Host & Microbe (2011)
The Management of Acute Frontal Sinusitis
Authors: Robert L. Goodale
Journal: New England Journal of Medicine (1951)

THE purpose of this paper is to review the recent trends in the control of acute bacterial infections of the frontal sinus consequent to the impact on therapeutic concepts of the bacteriostatic and bactericidal agents during the last decade. The results in the field of otolaryngology have been so dramatic in reducing the complications of upper-respiratory infections requiring surgery that there is a widespread belief that the "wonder drugs" have supplanted all previous methods of treatment. One has only to remember the prevalence of surgical mastoiditis before the advent of chemotherapy and to compare that era with the present day . . .
94 RUPTURE OF LIVER TOLERANCE TO LPS BY GILZ DOWREGULATION IN OBESITY-RELATED LIVER INFLAMMATION
Authors: H. Boujedidi, A. Bigorgne, L. Bouchet-Delbos, A.-M. Cassard-Doulcier, O. Robert, T. Tran, I. Durand-Gasselin, F. Capel, P. Hemon, S. Prévot, S. Rousset, R. Douard, S. Naveau, V. Godot, D. Emilie, M. Lombes, G. Perlemuter
Journal: Journal of Hepatology (2012)
THE BARRACUDA (SPHYRAENA) DANGEROUS TO MAN
Authors: E. W. GUDGER
Journal: JAMA (1928)

The barracuda is a large, savage, superficially pikelike fish of tropical and subtropical seas. Because of its considerable size and voracious habits, it has long been accused of attacking men bathing or accidentally falling into the water. For this reason it has been of much interest to physicians as well as ichthyologists. A definite case of this habit having come directly to the attention of one of us, and the literature having been thoroughly worked up by the other, we have thought that it would be of interest and value if these data were brought together and presented in definite form to medical men and to others who might be interested. <h3>REPORT OF ATTACK ON MAN NEAR COLON BY SPHYRAENA BARRACUDA</h3> While Breder was confined in the United States Naval Hospital at Colon in 1924, with fever contracted while carrying on zoological explorations in the Darien jungle, there was brought
TRANSFUSION OF BLOOD AND BLOOD SUBSTITUTES
Authors: Elmer L. DeGowin
Journal: JAMA (1941)

To the Editor:—   concluding paragraph of the editorial Transfusion of Blood and Blood Substitutes (The Journal, November 8, p. 1627) contains the statement The dried plasma promises to be the eventual solution of the problem for war emergency because of the greater stability, smaller bulk and the relative simplicity of packing, storing and transporting. This seems to me to be an oversimplification of the problem.  experimental and clinical studies in Great Britain and in this country have proved conclusively the efficacy of transfusions of plasma and serum in the first aid treatment of shock. Even shock accompanying hemorrhage can be treated successfully by restitution of the blood volume with serum or plasma, provided the bleeding is controlled.  personnel of the British Army Blood Supply Depot under the command of Col. L. E. H. Whitby has had a rare opportunity to study the treatment of shock in air
Manual of Clinical Oncology
Authors: David T. Carr
Journal: JAMA (1983)

The medical student and young graduate physician who want to learn more about cancer are confronted with a plethora of manuals, handbooks, textbooks, and encyclopedias. Some attempt to report on all aspects of oncology and are usually used as reference books. Others cover a limited segment of oncology and do so in great depth. Few are suitable for the student to read from cover to cover. This third edition of the Manual of Clinical Oncology , published by the International Union Against Cancer (UICC), is comprehensive, yet short enough to be read from cover to cover by the student who wishes a general review of the subject of oncology.  The first section deals with general aspects of cancer such as etiology, pathology, diagnosis, and general principles of treatment.  Cancers of specific sites are described in the second section.  Ongoing basic science of imminent impact on clinical oncology is reviewed in the
Reasons for the lack of benefit of immediate angioplasty during recombinant tissue plasminogen activator therapy for acute myocardial infarction: A regional wall motion analysis
Authors: Alfred E.R. Arnold, Patrick W. Serruys, Wolfgang Rutsch, Maarten L. Simoons, David P. De Bono, Jan G.P. Tijssen, Jacobus Lubsen, Marc Verstraete
Journal: Journal of the American College of Cardiology (1991)
LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity
Authors: Gengze Wu, Jin Cai, Yu Han, Jinghai Chen, Zhan-Peng Huang, Caiyu Chen, Yue Cai, Hefei Huang, Yujia Yang, Yukai Liu, Zaicheng Xu, Duofen He, Xiaoqun Zhang, Xiaoyun Hu, Luca Pinello, Dan Zhong, Fengtian He, Guo-Cheng Yuan, Da-Zhi Wang, Chunyu Zeng
Journal: Circulation (2014)

Long noncoding RNAs (lncRNAs) have recently been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs in atherosclerosis is largely unknown.We identified lincRNA-p21 as a key regulator of cell proliferation and apoptosis during atherosclerosis. The expression of lincRNA-p21 was dramatically downregulated in atherosclerotic plaques of ApoE(-/-) mice, an animal model for atherosclerosis. Through loss- and gain-of-function approaches, we showed that lincRNA-p21 represses cell proliferation and induces apoptosis in vascular smooth muscle cells and mouse mononuclear macrophage cells in vitro. Moreover, we found that inhibition of lincRNA-p21 results in neointimal hyperplasia in vivo in a carotid artery injury model. Genome-wide analysis revealed that lincRNA-p21 inhibition dysregulated many p53 targets. Furthermore, lincRNA-p21, a transcriptional target of p53, feeds back to enhance p53 transcriptional activity, at least in part, via binding to mouse double minute 2 (MDM2), an E3 ubiquitin-protein ligase. The association of lincRNA-p21 and MDM2 releases MDM2 repression of p53, enabling p53 to interact with p300 and to bind to the promoters/enhancers of its target genes. Finally, we show that lincRNA-p21 expression is decreased in patients with coronary artery disease.Our studies identify lincRNA-p21 as a novel regulator of cell proliferation and apoptosis and suggest that this lncRNA could serve as a therapeutic target to treat atherosclerosis and related cardiovascular disorders.