tbuckley/cabot-search huggingface dataset:
Lifelong Desquamation of the Hands and Feet
Authors: Joshua A. Grosshandler, Maria El-Charif, H. Nicholas Shamma
Journal: JAMA Dermatology (2014)

A man in his 60s presented with asymptomatic peeling of the hands and feet. The patient stated that this had occurred “for as long as he could remember.” The patient stated the peeling skin occurred predominately on his hands and feet but also occurred, less frequently, on his knees. The patient denied pruritus or burning sensation. He complained of hyperhidrosis, which seemed to exacerbate the condition, as well as mechanical trauma, including activities such as long walks when wearing shoes. The patient denied any change in the condition with seasonal variation. He denied having any other family members with similar findings. Physical examination revealed fine scaling, bilaterally, on the dorsal surface of the hands and erythematous erosions with peripheral desquamation located on the dorsal and lateral aspects of the hand and digits. (Figure, A and B) A punch biopsy was performed on a blister found on the right palmar surface, and the specimen was processed and stained with hematoxylin-eosin (Figure, C). What is your diagnosis?
GENERAL AND ABDOMINAL ADIPOSITY INDICES AS PREDICTORS OF CORONARY ARTERY DISEASE IN HYPERTENSIVE PATIENTS: A SIX-YEAR FOLLOW-UP STUDY
Authors: Konstantinos P. Tsioufis, Kyriakos Dimitriadis, Alexandros Kasiakogias, Michalis Giakoumis, Ioannis Andrikou, Panagiota Valenti, Dimitris Flessas, Velissarios Antonakis, Panagiotis Vasileiou, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2013)
Preventing Falls in Acute Care Hospitals—Reply
Authors: Patricia C. Dykes
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reflected Ultrasound in the Assessment of Mitral Valve Disease
Authors: CLAUDE R. JOYNER, JOHN M. REID, JAMES P. BOND
Journal: Circulation (1963)

An ultrasound beam directed into a medium of uniform acoustical impedance will travel in a straight line, but a portion of the waves will be reflected at the interface of a medium of different acoustical impedance. A time-distance curve of motion has been obtained from the heart by recording the echoes returned to a send-receive ultrasound transducer applied in the third, fourth, or fifth left interspace. A characteristic curve having two anterior peaks during each cardiac cycle was obtained in the 25 normal patients studied. One peak follows the P wave of the electrocardiogram and is not seen in atrial fibrillation. The other peak of motion toward the anterior chest is followed by rapid regression posteriorly during ventricular diastole. The velocity of the motion was 85 to 160 mm./sec. in normal subjects. In contrast, the records from 90 patients with mitral stenosis demonstrated a distinctive, abnormal pattern having a plateautype configuration with a velocity of posterior motion of only 2 to 35 mm./sec. The configuration of the curve changed toward normal after successful mitral valvulotomy but none of the 35 patients who were studied before and after surgery has developed a calculated postoperative velocity exceeding 70 mm./sec. Twelve patients with "pure" mitral regurgitation have had records similar to the normal, with velocities in or above the normal range. None of the 135 other patients studied, representing a variety of conditions, demonstrated a curve of the type found in mitral stenosis.
Association of Atrial Fibrillation and Obstructive Sleep Apnea
Authors: Apoor S. Gami, Gregg Pressman, Sean M. Caples, Ravi Kanagala, Joseph J. Gard, Diane E. Davison, Joseph F. Malouf, Naser M. Ammash, Paul A. Friedman, Virend K. Somers
Journal: Circulation (2004)

Obstructive sleep apnea (OSA) is associated with recurrent atrial fibrillation (AF) after electrocardioversion. OSA is highly prevalent in patients who are male, obese, and/or hypertensive, but its prevalence in patients with AF is unknown.We prospectively studied consecutive patients undergoing electrocardioversion for AF (n=151) and consecutive patients without past or current AF referred to a general cardiology practice (n=312). OSA was diagnosed with the Berlin questionnaire, which is validated to identify patients with OSA. We also assessed its accuracy compared with polysomnography in a sample of the study population. Groups were compared with the 2-tailed t, Wilcoxon, and chi2 tests. Logistic regression modeled the association of AF and OSA after adjustment for relevant covariates. Patients in each group had similar age, gender, body mass index, and rates of diabetes, hypertension, and congestive heart failure. The questionnaire performed with 0.86 sensitivity, 0.89 specificity, and 0.97 positive predictive value in our sample. The proportion of patients with OSA was significantly higher in the AF group than in the general cardiology group (49% versus 32%, P=0.0004). The adjusted odds ratio for the association between AF and OSA was 2.19 (95% CI 1.40 to 3.42, P=0.0006).The novel finding of this study is that a strong association exists between OSA and AF, such that OSA is strikingly more prevalent in patients with AF than in high-risk patients with multiple other cardiovascular diseases. The coinciding epidemics of obesity and AF underscore the clinical importance of these results.
Orally active desulfated low molecular weight heparin and deoxycholic acid conjugate, 6ODS-LHbD, suppresses neovascularization and bone destruction in arthritis
Authors: Seung Rim Hwang, Dong-Hyun Seo, Taslim A. Al-Hilal, Ok-Cheol Jeon, Jin Hee Kang, Sung-Hyun Kim, Han Sung Kim, Young-Tae Chang, Young Mo Kang, Victor C. Yang, Youngro Byun
Journal: Journal of Controlled Release (2012)
Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings
Authors: Charlotte R Hedin, Neil E McCarthy, Petra Louis, Freda M Farquharson, Sara McCartney, Kirstin Taylor, Natalie J Prescott, Trevor Murrells, Andrew J Stagg, Kevin Whelan, James O Lindsay
Journal: Gut (2014)

<h3>Objective</h3> Crohn9s disease (CD) is associated with intestinal dysbiosis, altered blood T cell populations, elevated faecal calprotectin (FC) and increased intestinal permeability (IP). CD-associated features present in siblings (increased risk of CD) but not in healthy controls, provide insight into early CD pathogenesis. We aimed to (1) Delineate the genetic, immune and microbiological profile of patients with CD, their siblings and controls and (2) Determine which factors discriminate between groups. <h3>Design</h3> Faecal microbiology was analysed by quantitative PCR targeting 16S ribosomal RNA, FC by ELISA, blood T cell phenotype by flow cytometry and IP by differential lactulose-rhamnose absorption in 22 patients with inactive CD, 21 of their healthy siblings and 25 controls. Subject9s genotype relative risk was determined by Illumina Immuno BeadChip. <h3>Results</h3> Strikingly, siblings shared aspects of intestinal dysbiosis with patients with CD (lower concentrations of <i>Faecalibacterium prausnitzii</i> (p=0.048), Clostridia cluster IV (p=0.003) and <i>Roseburia</i> spp. (p=0.09) compared with controls). As in CD, siblings demonstrated a predominance of memory T cells (p=0.002) and elevated naïve CD4 T cell β7 integrin expression (p=0.01) compared with controls. FC was elevated (&gt;50 μg/g) in 8/21 (38%) siblings compared with 2/25 (8%) controls (p=0.028); whereas IP did not differ between siblings and controls. Discriminant function analysis determined that combinations of these factors significantly discriminated between groups (χ<sup>2</sup>=80.4, df=20, p&lt;0.001). Siblings were separated from controls by immunological and microbiological variables. <h3>Conclusions</h3> Healthy siblings of patients with CD manifest immune and microbiological abnormalities associated with CD distinct from their genotype-related risk and provide an excellent model in which to investigate early CD pathogenesis.
The Problem of Integrating Biological and Psychodynamic Views in Psychotherapeutic Training of Physicians
Authors: Friedrich Krull
Journal: Psychotherapy and Psychosomatics (1990)

A clinical seminar was arranged for the purpose of examining the special problems of doctors undergoing supplementary training in psychotherapy. Diagnostic and therapeutic problems analyzed during the seminar could be attributed to a one-sided overemphasis of either somatic or psychodynamic findings. The physician tends to administer only pharmacotherapy for illness of supposed organic origin, and only psychotherapy for disorders of supposed psychological origin. Yet most of mental diseases require a synthesis of both biological and psychological procedures. There is no special psychotherapeutic technique, which distinguishes the medical psychotherapist but the ability to integrate psychological and somatic perspectives of the patient.
INDOOR AIR QUALITY: Scented Products Emit a Bouquet of VOCs
Authors: Carol Potera
Journal: Environmental Health Perspectives (2010)

Scented Products Emit a Bouquet of VOCsA survey of selected scented consumer goods showed the products emitted more than 100 volatile organic compounds (VOCs), including some that are classified as toxic or hazardous by federal laws. 1 Even products advertised as "green," "natural," or "organic" emitted as many hazardous chemicals as standard ones.
Hypertension in pregnancy managed at home by community midwives.
Authors: J G Feeney
Journal: BMJ (1984)

Intravenous sedation for upper gastrointestinal endoscopy: diazepam versus midazolam Intravenous diazepam (Valium) has a long half life (>20 hours) and active metabolites and, possibly due to its vehicle, may damage veins; in contrast, midazolam hydrochloride (Hypnovel), a new water soluble imidazobenzodiazepine, has an elimination half life of about two hours.We compared these two drugs as sedatives for elective upper gastrointestinal endoscopy.
Suppression of premature ventricular contractions by acebutolol.
Authors: A H Gradman, R A Winkle, J W Fitzgerald, P J Meffin, J Stoner, P A Bell, D C Harrison
Journal: Circulation (1977)

The antiarrhythmic action of the beta-blocking drug, acebutolol, was evaluated in patients with frequent premature ventricular contractions (PVCs). In the 12 hours following administration of a single 300 mg oral dose, 8 of 10 patients showed a greater than 50% reduction in PVC frequency, and statistical analysis indicated that PVC reduction persisted for 10 hours after the single dose. Analysis of plasma concentrations of acebutolol and an acetyl metabolite indicated that after single oral doses of plasma concentrations of the metabolite exceed those of unchanged acebutolol. When patients were studied during periods of 300 mg doses every 8 hours, eight of 11 showed a 70% reduction in PVC frequency, and analysis showed that the therapeutic effect was present throughout the 24-hour monitoring period. Acebutolol slowed the heart rate and prolonged the PR interval without affecting the QT interval. Significant clinical or laboratory toxicity was not encountered. In the small group studied, acebutolol was found to be safe and effective for short-term administration to patients with frequent PVCs and possessed a relatively long duration of antiarrhythmic action.
Debates on Diabetes
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1977)

IN medicine, as in the rest of this political world, there is nothing like a fiat to unite and give voice to the opposition. About a year ago, printed in this Journal as an editorial, a statement by the American Diabetes Association was intended to squash once and for all the "heresy" that control — variously labeled "good", "rigid", "tight" or "chemical" — of the diabetic patient's blood sugar was unimportant in preventing late complications such as nephropathy and retinopathy. "The goals of appropriate therapy should thus include a serious effort to achieve levels of blood glucose as close to . . .
Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid
Authors: Reiko Inagi, Toshio Miyata, Yasuhiko Ueda, Atsushi Yoshino, Masaomi Nangaku, Charles Van Ypersele De Strihou, Kiyoshi Kurokawa
Journal: Kidney International (2002)
Virus resistance transferred from human rheumatoid cells to rabbit synovial cells. II. Cell fusion.
Authors: C Smith, D Hamerman
Journal: Annals of the Rheumatic Diseases (1974)

Cultured human rheumatoid synovial cells (RSC) appear resistant to lytic infection with rubella virus (RV) in contrast to the susceptibility of nonrheumatoid synovial cells (NSC) (Grayzel and Beck, 1970).In the previous paper we reported transfer of RV resistance from RSC to rabbit synovial cells by means of intra-articular injection of RSC into normal rabbit joints (Smith, Hamerman, Janis, and Habermann, 1974).In parallel with these studies, we attempted to transfer RV resistance from RSC to other cells by the technique of cell fusion.These efforts were successful when normal rabbit synovial cells were used as the 'susceptible cell'. Material and methods CULTURE MEDIUMDulbecco-modified Eagle's medium with 10 per cent.calf serum was used at all times unless otherwise noted.
Maternal Age and Foetal Oxygenation
Authors: E. P. N. Turnbull, D. Baird
Journal: BMJ (1957)

Increased excretion of urinary total 17-OHCS is not always the result of increased hydrocortisone secretion by the adrenal cortex.Steroids with a 17.20 diol, or 21-deoxyketol type of side chain, give rise to 17-ketosteroids in this procedure (Appleby and Norymberski, 1955).Normally they are present in only small amount, but in adrenal cortical carcinoma and congenital adrenal hyperplasia they may be greatly increased.The high urinary total 17-OHCS excretion does not then reflect an increase of hydrocortisone production, but the clinical condition is usually clear and does not suggest Cushing's syndrome. SummarySome of the problems in the laboratory diagnosis of chronic adrenal insufficiency and Cushing's syndrome are discussed.A major difficulty has been the lack of any convenient method for estimating hydrocortisone and its metabolites in the urine.A method based on the Norymberski procedure for m2asuring total 17-hydroxycorticosteroids is described.The steroid outputs of normal subjects were 7.6 to 23.6 mg. per 24 hours in men, and 4.6 to 17.8 mg. per 24 hours in women.In 100 estimations on urines from adrenalectomized patients the steroid output showed good correlation with the dose of cortisone acetate.The effect of injections of corticotrophin gel on total urinary 17-hydroxycorticosteroid excretion was com- pared with that on the 17-ketosteroids.It is concluded that corticotrophin tests for adrenal cortical insufficiency are more sensitive if total 17-hydroxycorticosteroids are estimated.The total 17-hydroxycorticosteroids were measured in 15 cases of Cushing's syndrome and three of virilizing adrenal cortical carcinoma.Estimation of the total urinary 17-hydroxycorticosteroids was of diagnostic value in Cushing's syndrome and should make it unnecessary to undertake numerous time-consuming investigations in patients suspected of having this condition.APPENDIX Method for Estimation of Urinary Total 17-Hydroxycorticosteroids (Total 17-OHCS) A 24-hour urine collection is made without preservative; if the total volume is less than two litres, it is made up to two litres with distilled water.20 ml. of urine is placed in a 50-ml.ground-glass stoppered test-tube and 100 mg.sodium borohydride added.Excess frothing may be stopped by adding a few drops of ether.*The tube is allowed to stand overnight at room temperature, and next morning 20 ml.glacial acetic acid (A.R.) and
Enhanced Scintigraphic Protocol Required for Optimal Preoperative Localization Before Targeted Minimally Invasive Parathyroidectomy
Authors: Paige B. Clark, Doug Case, Nat E Watson, Nancy D. Perrier, Kathryn A. Morton
Journal: Clinical Nuclear Medicine (2003)

At our tertiary care institution, a targeted minimally invasive parathyroidectomy (MIP) is the preferred surgical procedure for primary hyperparathyroidism. Similar to unilateral neck exploration (UNE), preoperative scintigraphic localization of the adenoma in relation to the midline is required. However, in contrast to the abbreviated standard incision for UNE, 2 distinct incision sites, 1 medial and 1 lateral, are available on each side with MIP. The incision site is ultimately chosen based on scintigraphic determination of the adenoma's vascular origin to facilitate ligation and removal. Unfortunately, the scintigraphic location of a parathyroid adenoma does not necessarily reflect the site of its vascular origin. We reviewed our database to identify factors that accurately predict the site of vascular origin of parathyroid adenomas. A retrospective chart review was performed on 125 patients who underwent Tc-99m sestamibi scintigraphy and parathyroidectomy. Scintigraphic localization, surgical findings, and histopathology were recorded. Preoperative image interpretations that were discordant with operative findings were independently reviewed. Scintigraphy identified the presence of an adenoma in 105 of 118 patients (89%) with primary hyperparathyroidism. In 17 of the 105 cases (16%), the scintigraphic interpretation did not accurately reflect the site of superior or inferior vascular origin seen at surgery. In many discordant cases, anterior images were insufficient for determining the vascular origin. The posterior displacement of an adenoma in relation to the thyroid on early lateral images was often critical in determining the superior or inferior vascular origin. Scintigraphic determination of the superior or inferior vascular origin of a parathyroid adenoma directs incision placement for MIP. Imaging protocols should include early lateral images when localizing parathyroid adenomas before minimally invasive parathyroidectomy.
Nasal and Vaginal Staphylococcus aureus in Young Women: Quantitative Studies
Authors: R. RUSSELL MARTIN
Journal: Annals of Internal Medicine (1982)

On quantitative cultures using media selective for staphylococci, 15 of 145 healthy women (10.3%) had Staphylococcus aureus isolated from the vagina; numbers of staphylococci ranged from 3 X 101 to 7.3 X 107 per swab. Nine of 15 women who were S. aureus vaginal carriers were also nasal carriers, but only 30 of 130 of women without vaginal S. aureus also had coagulase-positive staphylococci in the nose (p=0.002). Among women with S. aureus at both sites, the numbers of vaginal and nasal staphylococci isolated were not correlated. No association was found between the presence of vaginal staphylococcal colonization and the use of tampons compared to napkins. Cultures taken during menstruation from which S. aureus were isolated contained significantly higher numbers of coagulase-positive staphylococci (mean log ± SE of 4.0 ± 0.3) than positive cultures after menstruation (3.3 ± 0.2) (p < 0.02).
Abstract 2079: Estrogen receptor alpha expression with miR-206 trans-acting regulation roles in breast cancer cell lines
Authors: Young Eun Choi, Junkyu Song, Yong Hwa Jo, Hyun Mi Park, Kyung-Sik Yoon
Journal: Cancer Research (2010)

Abstract Estrogen receptor-alpha (ER-α) is present in 65% of human breast tumors. Tamoxifen(Tam) was only effective in ER-α expressed breast cancer cell lines. Also, it was reported that miR-206 decreases endogenous ER-α mRNA and protein levels in human MCF-7 breast cancer cells. We expect that effect of invasion and apoptosis in breast cancer cells by regulating expression of miR-206. Hence, we demonstrated that trans-acting regulation roles by ER-α and miR-206 in breast cancer cell line. MCF-7(ER hyper-expressed), MDA-MB231(ER hypo-expressed), MCF-10A(ER hypo-expressed normal breast cell line) cells were targeted experiments. Cell viability was analyzed by dose-dependent Tamoxifen with MTT assay. Whole-cell extracts were observed for protein levels of ER-α, ERK, p38, p-ATM, ATM, p-chk2, chk2, p-p53, p53, cyclinD1 with western blotting. By using, ER-α, p38, miR206 activator/inhibitor and real-time PCR, we studied change of molecules in cell lines. Cell viability of MCF-7 cell was reduced about 85% of the cells were dead by 5, 7μM Tam. ERK phosphorylation was increased by dose-dependent Tam in both MCF-7 cell and by 7μM Tam treatment in MDA-MB231 cell. Also, p38 phosphorylation was raised by dose-dependent Tam in MCF-7 cells and MDA-MB231 cells. ATM, chk2, p53 that involved DNA damage molecules were not affect by dose-dependent Tam. CyclinD1 known as cell cycle G1 regulation molecule was decrease by effect of Tam. Also, miR-206 levels by real-time PCR were lessening in MCF-7 and increase in MDA-MB231 and MCF-10A. Specific molecules of MCF-7, MDA-MB231 and MCF-10A were influenced by ER-α, p38, miR-206 activator/inhibitor. ER-α regulation and miR-206 expression were shown to trans-activated roles in breast cancer cell lines. Therefore, inhibition of miR-206 was accompanying the hyper-sensitivity of anticancer drug Tamoxifen that mediated ER-α. Whereas, miR-206 over expressed put down the invasion properties of breast cancer. We suggest that these roles of miR-206 will take the strategy for valuable breast cancer therapy. Keywords: ER-α, miR-206, Tamoxifen, breast cancer Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2079.