tbuckley/cabot-search huggingface dataset:
Significant differences in flow standardised breath sound spectra in patients with chronic obstructive pulmonary disease, stable asthma, and healthy lungs.
Authors: L P Malmberg, L Pesu, A R Sovijarvi
Journal: Thorax (1995)

<h3>Objective</h3> Research on the antidepressant effects of sleep deprivation (SD) is lagging and has not produced completely uniform results in humans and animals. The present study aimed to reassess the effect of SD on patients and animals by meta-analysis based on updated research. <h3>Methods</h3> We searched PubMed, Embase and Cochrane Library for articles since the first relevant literature published up to June 10th, 2019. Data on sample characteristics, features of SD, and tests for depression were extracted. <h3>Results</h3> Fourteen articles were included, eight on humans and six on animals. We found that when the duration of SD in patients was 7–14 days, it reflected antidepression [-1.52 (−2.07, −0.97); I<sup>2</sup>=19.6%]. In animals, the results of sucrose consumption experiments showed that SD has depressogenic effects [-1.06 (−1.63, −0.49); I<sup>2</sup>=81.1%], while the results of forced swimming experiments showed that SD treated depression [-1.17 (−2.19, −0.16); I<sup>2</sup>=80.1%], regardless of the duration of sleep deprivation. <h3>Conclusion</h3> SD can be an effective antidepressant measure when the duration is 7–14 days in patients. In animal studies, SD has shown more antidepressant effects when measured by forced swimming experiments, whereas using sucrose consumption tests had the effect of worsening depression.
Oxidative-stress and IL-6 mediate the fibrogenic effects of rodent Kupffer cells on stellate cells
Authors: Natalia Nieto
Journal: Hepatology (2006)

The impact of Kupffer cells (KCs) on the hepatic stellate cell (HSC) fibrogenic response was examined in an in vitro coculture model of primary KCs and HSCs. Coculture with KCs induced a more activated phenotype and greater proliferation compared to HSC cultured alone. Similar results were obtained on Matrigel which maintains HSCs quiescent. The effect of KCs on HSC collagen I involved transcriptional regulation, as determined by nuclear in vitro transcription run-on assays, promoter studies, and Northern blot analysis, while stability of the COL1A1 and COL1A2 mRNA were similar. The minimal COL1A1 and COL1A2 promoter regions responsible for the KC effects were localized to the −515 and −378 base pair (bp) regions, respectively. Intracellular and extracellular collagen I protein, H2O2, and IL-6 increased in a time-dependent fashion, especially for HSCs in coculture. Catalase prevented these effects as well as the transactivation of both collagen promoters. The rate of collagen I protein synthesis and intracellular collagen I degradation remained similar but the t 1/2 of the secreted collagen I was lower for HSC in coculture. MMP13, a protease that degrades extracellular collagen I, decreased in the cocultures, while TIMP1, a MMP13 inhibitor, increased; and these effects were prevented by catalase, anti-IL-6, and siRNA-IL-6. Cocultured HSC showed elevated phosphorylation of p38 which when inhibited by catalase, anti-IL-6, and siRNA-IL-6 it blocked TIMP1 upregulation and collagen I accumulation. In conclusion , these results unveil a novel dual mechanism mediated by H2O2 and IL-6 by which KCs may modulate the fibrogenic response in HSCs. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html).
A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis
Authors: Vlad Ratziu, Muhammad Y. Sheikh, Arun J. Sanyal, Joseph K. Lim, Hari Conjeevaram, Naga Chalasani, Manal Abdelmalek, Anezi Bakken, Christophe Renou, Melissa Palmer, Robert A. Levine, Raj B. Bhandari, Melanie Cornpropst, Wei Liang, Benjamin King, Elsa Mondou, Franck S. Rousseau, John McHutchison, Mario Chojkier
Journal: Hepatology (2011)

In nonalcoholic steatohepatitis (NASH), the extent of hepatocyte apoptosis correlates with disease severity. Reducing hepatocyte apoptosis with the selective caspase inhibitor GS-9450 has a potential for altering the course of the liver disease. In this phase 2, double-blind study, 124 subjects with biopsy-proven NASH were randomized to once-daily placebo or 1, 5, 10, or 40 mg GS-9450 for 4 weeks. Absolute and percent changes from baseline in ALT levels, AST levels, and caspase-3-cleaved cytokeratin (CK)-18 fragments at week 4 were assessed by an analysis of covariance model with adjustment for baseline values. In the 40-mg group, mean (SD) ALT decreased by 47 (43) U/L from baseline to week 4 (P < 0.0001 versus placebo), and the proportion of subjects with normal ALT increased from 0% to 35% at week 4. In the 40-mg group, mean AST decreased by 13 U/L from baseline (not significant), and the proportion with normal AST increased from 20% at baseline to 48% at week 4. By week 4, mean CK-18 fragment levels had decreased to 393 (723) U/L in the GS-9450 10-mg group and 125 (212) U/L in the 40-mg group, but these reductions were not statistically significant. No serious adverse events were reported during treatment, and the percentage of subjects with at least one treatment-emergent grade 3 or 4 laboratory abnormality ranged from 11.5% to 17% across the GS-9450 treatment groups versus 35% in the placebo group.GS-9450 treatment induced significant reductions in ALT levels in NASH patients. Reductions in CK-18 fragment levels also occurred, although they were not statistically significant. At appropriate therapeutic indices, selective caspase inhibitors may be a promising treatment option in patients with NASH.
Abstract 4861: Pharmacological reversal of caffeine-mediated phagocytic suppression
Authors: Ryan Steck, Spencer Hill, Richard A. Robison, Kim L. O'Neill
Journal: Cancer Research (2014)

Abstract Caffeine's mechanism of action on immune cells has been an issue of debate for some time. Previous studies suggest caffeine inhibits cyclic AMP (cAMP)-phosphodiesterase, resulting in increased cAMP levels, increased protein kinase A (PKA) activation, and subsequently a decreased pro-inflammatory response. Caffeine is also an antagonist of adenosine receptors, resulting in delayed resolution of inflammation. If the primary effect of caffeine in macrophages was to antagonize adenosine receptors, we would expect caffeine to stimulate phagocytosis. We treated human macrophages with varying concentrations of caffeine (0 - 13mM) and measured their phagocytic ability to engulf fluorescent microspheres. Engulfment rates were measured by flow cytometry. Our results indicate that caffeine suppresses phagocytosis by 22% at physiological concentrations (35 uM- 750uM). At supraphysiological (4-13 mM) levels of caffeine, however, there is no significant decrease in phagocytosis. We wanted to find out if this suppressive effect at physiological concentrations could be blocked with a PKA inhibitor. We tested this by treating the cells with a PKA inhibitor at each of the different caffeine concentrations previously used. Initial results indicate that phagocytosis increased up to 27% in macrophages treated with PKA and caffeine compared to caffeine treated and control cells.These results need further validation but, initial results suggest inhibition of PKA results in increased engulfment, and indicate that the suppressive effects of caffeine on macrophage phagocytosis can be reversed with the treatment of PKA inhibitor suppression can be reversed. Macrophages are highly involved in regulation of inflammation and dysregulation has been implicated in a number of diseases, including cancer. These results suggest further potential for the therapeutic applications of caffeine, its analogs, and PKA inhibitors for the control of inflammation. Citation Format: Ryan Steck, Spencer Hill, Richard A. Robison, Kim L. O'Neill. Pharmacological reversal of caffeine-mediated phagocytic suppression. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4861. doi:10.1158/1538-7445.AM2014-4861
Plasma B-Type Natriuretic Peptide Levels and Recurrent Arrhythmia After Successful Ablation of Lone Atrial Fibrillation
Authors: Ayman A. Hussein, Walid I. Saliba, David O. Martin, Mazyar Shadman, Mohamed Kanj, Mandeep Bhargava, Thomas Dresing, Mina Chung, Thomas Callahan, Bryan Baranowski, Patrick Tchou, Bruce D. Lindsay, Andrea Natale, Oussama M. Wazni
Journal: Circulation (2011)

Plasma B-type natriuretic peptide (BNP) is abnormally elevated in patients with lone atrial fibrillation (AF). The exact significance and prognostic implications of this elevation have yet to be determined. Little is known about BNP in lone AF patients undergoing arrhythmia ablation. We sought to determine the relationship between BNP levels and the risk of recurrent arrhythmia after ablation of lone AF.We followed up 726 patients with lone AF undergoing first-time arrhythmia ablation. All had BNP levels measured on the day of ablation with of the point-of-care Triage Meter assay (Biosite Diagnostics, San Diego, CA). At baseline, factors associated with elevated BNP levels in multivariable linear regression analysis (with log BNP being the dependent variable) were older age (β regression coefficient for +1-year change, 0.025; P<0.0001), longer duration of AF (β for +1-year change, 0.031; P=0.01), nonparoxysmal AF (versus paroxysmal; β, 0.52; P<0.0001), and larger left atrial size (β for +1-cm(2) change, 0.040; P<0.0001). The BNP levels were strongly associated with arrhythmia recurrence in univariate- (hazard ratio for +1-log-BNP change, 2.32; 95% confidence interval, 2.11 to 2.74; P<0.001) and covariate- (hazard ratio for +1-log-BNP change, 2.13; 95% confidence interval, 2.06 to 2.38; P<0.001) adjusted Cox proportional hazards analysis. The covariate-adjusted hazard ratios for recurrent arrhythmia were 1.6, 2.7, 4.3, and 5.7 for the second, third, fourth, and fifth quintiles, respectively, compared with patients in the lowest quintile (P for trend across quintiles <0.001).B-type natriuretic peptide levels correlate with AF burden (chronicity, altered hemodynamics, and anatomic remodeling) in patients with lone AF and are strong predictors of recurrent arrhythmia after ablation. Elevated BNP levels may reflect increased cardiac chamber wall stress and/or intrinsic atrial disease, thus increasing the risk of arrhythmia recurrence.
History of infertility
Authors: P Morice
Journal: Human Reproduction Update (1995)

Journal Article History of infertility Get access Philippe Morice, Philippe Morice 3 1Service de Chirurgie Gynécologique, Clinique Universitaire BaudelocqueC.H.U Cochin Port-Royal, 123 Boulevard du Port-Royal, 75014 Paris 3 To whom correspondence should be addressed. Phone: 33-(I) 42 34 11 50; fax: 33-(1) 40 51 77 62 Search for other works by this author on: Oxford Academic PubMed Google Scholar Patrice Josset, Patrice Josset 2Service d'Anatomo-Pathologie, Hopital Trousseau26 Avenue du Docteur A. Netter, 75012 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles Chapron, Charles Chapron 1Service de Chirurgie Gynécologique, Clinique Universitaire BaudelocqueC.H.U Cochin Port-Royal, 123 Boulevard du Port-Royal, 75014 Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean Bernard Dubuisson Jean Bernard Dubuisson 1Service de Chirurgie Gynécologique, Clinique Universitaire BaudelocqueC.H.U Cochin Port-Royal, 123 Boulevard du Port-Royal, 75014 Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction Update, Volume 1, Issue 5, 1995, Pages 497–504, https://doi.org/10.1093/humupd/1.5.497 Published: 01 September 1995 Article history Received: 17 October 1994 Accepted: 30 May 1995 Published: 01 September 1995
Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3
Authors: Madhuri Bhandaru, Daniela S. Kempe, Anand Rotte, Paola Capuano, Ganesh Pathare, Mentor Sopjani, Ioana Alesutan, Leonid Tyan, Dan Yang Huang, Balasaheb Siraskar, Martin S. Judenhofer, Gerti Stange, Bernd J. Pichler, Jürg Biber, Leticia Quintanilla-Martinez, Carsten A. Wagner, David Pearce, Michael Föller, Florian Lang
Journal: Kidney International (2011)
Abstract 1098: Interactions between P53 and IGF2 in human esophageal adenocarcinoma tissues and cell lines
Authors: Ronghua Zhao, Alan G. Casson
Journal: Cancer Research (2011)

Abstract To define the role of the insulin-like growth factor (IGF) axis in esophageal adenocarcinoma (EADC), the objective of this study was to evaluate interactions between IGF2 and P53 in a well characterized series of surgically-resected esophageal tissues and the following cell lines: Het1A (derived from immortalized normal esophageal epithelium), OE33 and JH-EsoAd1 (each derived from a primary EADC). Nucleic acids were extracted from 68 primary EADC (and matched histologically normal) tissues. PCR was performed on gDNA and RT-PCR on RNA followed by ApaI digestion to identify informative (heterozygous) cases and imprinting status, respectively. Expression of IGF2 mRNA was determined by quantitative PCR, and of IGF2 and P53 protein by Western analysis and immunohistochemistry. Molecular findings in tissues were correlated with pathologic and clinical characteristics including patient survival. Functional studies utilizing cell lines evaluated IGF2/P53 interactions. Of 44 informative cases, P53 protein overexpression was significantly higher in normally imprinted tumors (12/30) vs. tumors with loss of IGF2 imprinting (1/14; p&amp;lt;0.05). Multivariable logistic regression confirmed IGF2 imprinting status to be independently associated with P53 expression (OR 0.12, 95% CI 0.01-1.00; p=0.05). Tumors overexpressing both IGF2 and P53 were found to be of advanced stage with poor survival. In patients below age 65 years, IGF2 mRNA expression was significantly higher in tumors with wild type P53, and multivariate analysis showed IGF2 mRNA expression to be independently associated with p53 mutation (OR 0.74, 95% CI 0.58-0.94; p&amp;lt;0.05) and P53 protein expression (OR 0.83, 95% CI 0.69-1.00; p&amp;lt;0.05). Whereas treatment of Het1A cells with IGF2 significantly increased P53 expression (1.34+/-0.06 vs. 1.00+/-0.00 untreated cells; p=0.003), IGF2 did not modulate P53 expression in either of the two tumor cell lines (OE33 and JH-EsoAd1). IGF1 Receptor (IGF1R) inhibition with AG1024 reduced P53 expression only in OE33 (0.48+/-0.22 vs. 1.00+/-0.00 untreated cells; p=0.05) and JH-EsoAd1 (0.71 +/- 0.23 vs. 1.00+/- 0.00 untreated; p = 0.15) cells, an effect not reversed by IGF2 treatment. In conclusion: 1) these studies identify novel molecular regulatory interactions between P53 and IGF2 in esophageal malignancy, which are dependent on IGF2 imprinting status and tissue/cell type. 2) Overexpression of both IGF2 and P53 in esophageal tumors is associated with aggressive disease in younger patients (below age 65 years), and may represent clinically useful biomarkers to define a biologically distinct subset of EADC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1098. doi:10.1158/1538-7445.AM2011-1098
"THE FALLACY OF SAHLI 'DESMOID REACTION'"
Authors: Jacob Buckstein
Journal: JAMA (1924)

To the Editor:  —Shorn of all that is unessential, the criticism of Dr. Hermann Sahli (The Journal, January 5, p. 51) of my method of proving the digestion of connective tissue within the small intestine of the human being, depends on the following: 1. Is the end of the rubber tube with the attached tip actually passed within the small intestine? 2. Can the detachability of the metal tip, with the end of the rubber tube still present within the small intestine, be  proper criterion for the opinion that the connective tissue suture has disintegrated?  1. Dr. Sahli states that the procedure is of questionable value, for the following reasons: That the passage of  rubber tube into the duodenum is  procedure that may occasionally be successful, and the fact that this may occur with a moderate amount of certainty has not been proved. It has been my
Medical equipment for expeditions
Authors: G T Haneveld
Journal: BMJ (1981)

moon.Had we included admissions for self-injury and accidental poisoning, including smoke injury, the figures would have been 390 and 336.The mean number of selfpoisoning admissions, with standard deviation, on full moon days was 5 9 2 3 (range 2-10) but on new moon days only 5-1 2 6 (0-12).We made comparisons for each full moon and new moon pair, and found t= 1 8487, df= 61.If we merely ask whether there might be a significant difference among the pairs then p = 007, which does not reach standards for significance.However, the report from India specified a direction of difference and allowed a prediction, and if we consequently adopt a one-tailed test then p =0035.The likelihood that the higher rate of admissions for poisoning on full moon days than on new moon days in Edinburgh, as in Patna, could be a matter of chance alone would thus be only about 1 in 28.
Pleurectomy for persistent pain in benign asbestos-related pleural disease.
Authors: D I Fielding, J L McKeon, W A Oliver, K Matar, I G Brown
Journal: Thorax (1995)

Persistent severe pain is a rare complication of benign asbestos-related pleural disease.Four patients are described in whom pain persisted for more than one year (range 18 months to five years) which was incompletely relieved by opioid medication and nerve blocking procedures. All underwent pleurectomy in an attempt to relieve it.At operation the pleura was considerably thickened in all cases. Two of the four patients had successful relief of pain. The other two had a neuralgic component to their pain before surgery which persisted afterwards. One of these patients underwent successful cervical cordotomy.Pleurectomy may provide relief in patients with constant pleuritic pain due to benign asbestos-related pleural thickening. It seems, however, that patients in whom the pain has a neuralgic component are unlikely to benefit.
Glucose Control and Renal and Retinal Complications of Diabetes Mellitus
Authors: Grant Gwinup
Journal: JAMA (1990)

To the Editor.—  Reading the article from the Colorado Group 1 entitled Glucose Control and Renal and Retinal Complications of Insulin-dependent Diabetes was very much like moving back in time to the 1950s and 1960s. In those years a number of similar articles were published that gave rise to the widely accepted but unsupported notion that instituting more rigid control of blood  levels would benefit the eyes and kidneys of diabetics. The recent article is, for all intents and purposes, a verbatim reproduction of those articles, except the term glycohemoglobin has been substituted for urinary glucose to reflect the more sophisticated methodology employed.  Sophistication, however, cannot over-come the enormous non sequitur inherent in the authors' inference that rigid control of the blood  levels in their diabetic patients favorably altered their renal and retinal complications. The fallacy of the authors' conclusion should be obvious to any investigator. Only prospective
Persistent Vomiting in Infants treated by Continuous Nasal Drip-feeds
Authors: T. N. Nauth-Misir
Journal: BMJ (1946)

DISCUSSIONMost of the accessory livers recorded by Rolleston and McNee (1929) were attached to, or in close proximity to, the liver; mostly in the hepatic ligaments or directly attached to the liver or gall-bladder.One case is recorded by them of hepatic tissue in the omentum and scattered over the peri- toneum; and one with a nodule of liver tissue in a suprarenal gland.None had such an attachment to the pancreas as was found in this case.They do, however, record the occurrence, reported by Mohamet, of an accessory liver attached to the tip of the gall-bladder in a case of cirrhosis; the accessory liver was also cirrhotic.
Efficacy of the Implantable Cardioverter-Defibrillator in the Elderly
Authors: Panagiotis T Panotopoulos, Kathi Axtell, Alfred J Anderson, Jasbir Sra, Zalmen Blanck, Sanjay Deshpande, Michael Biehl, Edward T Keelan, Mohammad R Jazayeri, Masood Akhtar, Anwer Dhala
Journal: Journal of the American College of Cardiology (1997)
Pancreatic elastase‐1‐producing B‐cell lymphoma
Authors: Naokuni Uike, Youko Suehiro, Hiroyuki Takahira, Masahiro Kikuchi, Akihiro Funakoshi, Takashi Nakashima, Yasushi Nomura, Atsuo Jimi, Koh‐Ichi Ohshima, Morishige Takeshita, Mitsuo Kozuru
Journal: American Journal of Hematology (1994)
Predicting survival in adults with invasive aspergillosis during therapy for hematological malignancies or after hematopoietic stem cell transplantation: Single‐center analysis and validation of the Seattle, French, and Strasbourg prognostic indexes
Authors: Rocio Parody, Rodrigo Martino, Ferran Sánchez, Maricel Subirá, Alberto Hidalgo, Jorge Sierra
Journal: American Journal of Hematology (2009)

In this retrospective monocenter study, we analyzed the outcomes of 130 adult hematological patients who developed a proven (n = 23), probable (n = 71), and possible (n = 36) invasive aspergillosis (IA) in a 13-year period. Forty-nine patients (38%) were recipients of an allogeneic hematopoietic stem cell transplantation (AlloHSCT). The main goal of the study was the identification of prognostic factors for 4-month aspergillosis free survival (AFS) and overall survival (OS). IA was identified as the main cause of death in 27/49 recipients of an AlloHSCT (55%) and 28/81 nontransplanted patients (35%). Diagnosis of IA at or before 2000 had a negative impact in both 4-month AFS and 4-month OS in the entire group. In multivariate analysis performed separately for nontransplanted and allo-HSCT patients, five variables (excluding the year of diagnosis) decreased 4-month AFS: (i) impairment of one organ function (OF), (ii) impairment of two or more OFs (two points), (iii) disseminated IA, (iv) neutropenia lasting more than 10 days (non-AlloHSCT group only) or monocytopenia (<0.1 x 10(9)/l) [AlloHSCT group only], and (v) high-dose steroids (non-AlloHSCT group only) or an alternative donor (AlloHSCT group only). According to the number of adverse risk factors, three prognostic subgroups were defined in non-transplanted and alloHSCT patients with good (97% and 78% AFS), intermediate (73% and 32% AFS) and poor prognosis (20% and 11% AFS) of IA [P < 0.01]. In addition, we validated the French and Seattle prognostic indexes for allo-HSCT recipients and the Strasbourg model for all hematological patients with IA.
CHONDROMA OF INTERVERTEBRAL DISK
Authors: PAUL C. BUCY
Journal: JAMA (1930)

It is doubtful whether chondroma of the intervertebral disk, as originally described by Stookey,<sup>1</sup>is as rare as a review of the literature would indicate. The first reference to this condition to be found in the literature is by Adson,<sup>2</sup>who briefly mentioned one case with involvement of the cervical region; but the first detailed study was published in 1928 by Stookey, who reported seven cases, all arising in the cervical region. A year later von Péchy<sup>3</sup>reported one arising in the thoracic region, thus making a total of nine cases. Inquiry of Dr. A. W. Adson<sup>4</sup>reveals that he has since then seen at least three other cases, probably more. One of these arose in the thoracic region and one involved the cauda equina. Dr. Max M. Peet<sup>5</sup>informs me that he has had "at least three cases" of this type, one each in
A large tandem duplication within the COL4A5 gene is responsible for the high prevalence of Alport syndrome in French Polynesia
Authors: Christelle Arrondel, Georges Deschênes, Yannick Le Meur, Amandine Viau, Christophe Cordonnier, Alain Fournier, Stephane Amadeo, Marie-Claire Gubler, Corinne Antignac, Laurence Heidet
Journal: Kidney International (2004)