tbuckley/cabot-search huggingface dataset:
Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma
Authors: Sally E. Trabucco, Rachel M. Gerstein, Andrew M. Evens, James E. Bradner, Leonard D. Shultz, Dale L. Greiner, Hong Zhang
Journal: Clinical Cancer Research (2014)

Approximately 50% of patients with diffuse large B-cell lymphoma (DLBCL) enter long-term remission after standard chemotherapy. Patients with DLBCL who do not respond to chemotherapy have few treatment options. There remains a critical need to identify effective and targeted therapeutics for DLBCL.Recent studies have highlighted the incidence of increased c-MYC protein in DLBCL and the correlation between high levels of c-MYC protein and poor survival prognosis of patients with DLBCL, suggesting that c-MYC is a compelling target for DLBCL therapy. The small molecule JQ1 suppresses c-MYC expression through inhibition of the bromodomain and extra-terminal (BET) family of bromodomain proteins. We investigated whether JQ1 can inhibit proliferation of DLBCL cells in culture and xenograft models in vivo.We show that JQ1 at nanomolar concentrations efficiently inhibited proliferation of human DLBCL cells in a dose-dependent manner regardless of their molecular subtypes, suggesting a broad effect of JQ1 in DLBCL. The initial G1 arrest induced by JQ1 treatment in DLBCL cells was followed by either apoptosis or senescence. The expression of c-MYC was suppressed as a result of JQ1 treatment from the natural, chromosomally translocated, or amplified loci. Furthermore, JQ1 treatment significantly suppressed growth of DLBCL cells engrafted in mice and improved survival of engrafted mice.Our results demonstrate that inhibition of the BET family of bromodomain proteins by JQ1 has potential clinical use in the treatment of DLBCL.
TCT-811 First-in-Human CardiAQ Transcatheter Mitral Valve Implantation via Transapical Approach
Authors: Lars Søndergaard, Matthew Brooks, Nikolaj Ihlemann, Susanne Holme, Anders Jonsson, Luigi Biasco, Mariann Tang, Peter B. Hansen, Peter S. Olsen, Arshad Quadri
Journal: Journal of the American College of Cardiology (2014)
585 IL-17 STIMULATING HBV LEAVING FROM PERIPHERAL BLOOD MONONUCLEAR CELLS MAY HELP HBV CLEARENCE IN THE SERUM OF CHRONIC HEPATITIS B PATIENTS UNDER PEGY-INTERFERON TREATMENT
Authors: H.Y. Zhang, J. Li, C.K. Hui, L. Lv, Y.H. Yeung, Y.D. Wang, D.W. Yie, G.K. Lau
Journal: Journal of Hepatology (2008)
Estrogen replacement therapy reverses changes in intramural coronary resistance arteries caused by female sex hormone depletion
Authors: M Mericli
Journal: Cardiovascular Research (2003)

Objective: We tested the hypothesis that female sex hormone depletion and estradiol replacement therapy significantly influences the biomechanical properties of intramural coronary resistance arteries. Design: Female rats (n = 30) were divided into three groups. In group O, rats were subjected to bilateral ovariectomy. Group HRT was subjected to bilateral ovariectomy and estradiol replacement therapy. Rats in group C served as controls. One month after ovariectomy, intramural coronary arteries (approximately 200 μm in diameter) branching from the left anterior descending coronary were isolated, cannulated and studied by microarteriography. Intraluminal pressure was increased in steps between 0 and 90 mm Hg. The steady state diameter at each step was measured. These measurements were repeated in the presence of U46619, a thromboxane (TX) A2 receptor agonist (at a concentration of 10−6 M), and bradykinin (BK; at 10−6 M). Finally, Ca2+-free Krebs-induced passive diameter (PD) was measured in each group. Results: Ovariectomy increased spontaneous myogenic tone of coronary arteries (p<0.05), which was normalized by estrogen replacement. Ovariectomy decreased distensibility observed at low pressure, although passive diameter was not changed. Estrogen replacement decreased wall stress and elastic modulus (p<0.05). The thromboxane A2 agonist induced the largest contraction in the ovariectomized group, whereas bradykinin-induced relaxation was the largest in the estrogen replacement group (p<0.05). Conclusion: Estradiol hormone replacement therapy (HRT) may exert a beneficial effect on myocardial perfusion in menopause by opposing the deterioration of biomechanical properties of intramural coronary resistance vessels induced by female sex hormone depletion.
Basic Atlas of Cross-Sectional Anatomy
Authors: R. M. Menegaz
Journal: JAMA (1981)

Started a dozen years ago, the trend to diminish the time spent on gross anatomy in medical education seems to be coming to an end. It began during a period of an increasing demand to crank up the output of physician-factories. Not surprisingly, it became apparent that the less well-educated the future physician, the less well-equipped he is to confront the enormous number and complexity of new technologies in medicine developed during these same years. By producing the<i>Basic Atlas of Cross-Sectional Anatomy</i>at this time, the authors and publisher are continuing the new, hopefully more intelligent, trend not only to educate properly the beginning student of medicine but to reeducate physicians in the anatomic basis for understanding their increasingly complex tools of diagnosis and treatment, such as computed tomography and ultrasonography. The authors are to be congratulated for their virtually error-free result, which shows concern both for accuracy in
Immunologic Reactivity in Leprosy
Authors: RAMON M. FUSARO
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 April 1970Immunologic Reactivity in LeprosyRAMON M. FUSARO, M.D., PH.D.RAMON M. FUSARO, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-4-602_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their article "Immunologic Reactivity in Patients with Leprosy," Sheagren and associates (1) report that "Levels of IgG and IgA immunoglobulins were increased in lepromatous disease while IgM levels were normal in all groups." This statement conflicts with recent findings (2, 3) in which patients with lepromatous and tuberculoid types of leprosy can be distinguished by the concentrations of their serum immunoglobulins. In lepromatous leprosy both IgG and IgM levels are significantly elevated, whereas in the tuberculoid type IgG and IgA levels are elevated. IgA levels are normal in lepromatous type, and IgM levels are normal in...References1. SHEAGRENBLOCKTRAUTMAN JJJ: Immunologic reactivity in patients with leprosy. Ann Intern Med 70:295-303, 1969 LinkGoogle Scholar2. LIMFUSARO SR: Serum immunoglobulin changes in leprosy and tuberculosis, in Proceedings of the XII Congress of International Dermatologiae, vol. 2, edited by JADASSOHN W, SCHIRREN CG, Berlin, Springer-Verlag, 1968, pp. 1332-1333 CrossrefGoogle Scholar3. LIMFUSARO SR: Leprosy. IV. The quantitation of immunoglobulins (IgG, IgM and IgA) in leprosy sera. Int J Leprosy 36:144-153, 1968 Google Scholar4. LIMFUSARO SR: Leprosy. V. A quantitative comparison of immune globulins (IgG, IgM, and IgA) in the sera of patients with pulmonary tuberculosis and patients with leprosy. Ibid., pp. 154-161 Google Scholar1. WILLIAMSCATHCARTCALKINS REE: Secondary amyloidosis in lepromatous leprosy. Ann Intern Med 62:1000-1007, 1965 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Dermatology University of Minnesota Minneapolis, Minn. 55455 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1970Volume 72, Issue 4Page: 602-602KeywordsAttentionLeprosyTuberculosis Issue Published: 1 April 1970 PDF downloadLoading ...
HIV epidemic is far worse than thought
Authors: J. Wise
Journal: BMJ (1997)

This article highlights the recent discovery that HIV is spreading faster than expected. The UN program on HIV/AIDS (UNAIDS) and the World Health Organization report that about 33% more people are living with HIV in the world than estimated in December 1996. Rates of HIV transmission have been grossly underestimated, particularly in sub-Saharan Africa. 1 in every 100 sexually active adults worldwide is believed to have an HIV infection, or 30 million people. By the year 2000, about 40 million are expected to have an HIV infection. The epidemic has developed differently in each country. Lake of data made comparisons difficult. In Uganda, which is not typical of sub-Saharan African countries, HIV infection rates are leveling off, particularly among younger age groups. UNAIDS estimates that about 9 out of 10 HIV-positive people are unaware that they are infected. This situation occurs because of the lack of facilities for HIV testing and counseling. An estimated 2.3 million died of AIDS in 1997, a 50% increase over 1996 mortality. Almost 50% of AIDS deaths in 1997 were among women, and 460,000 AIDS deaths occurred among children under 15 years old. In some African countries, the development gains made over the past decade are being erased. In Botswana, life expectancy rose from under 43 years to 61 years during 1955-90 and then declined to late 1960s levels in the late 1990s. Infant mortality in Zimbabwe is expected to rise by 138% by the year 2010 due to AIDS. There is a need in developing countries for an affordable means of slowing down the progression of HIV to AIDS and to increase protection among young people.
Radioactive Strontium Uptake
Authors: George V. LeRoy
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The question about radioactive strontium on page 920 ofThe Journal, Oct. 15, 1960, is an example of one of the current misconceptions concerning this subject. The statement, "In view of the fact that radioactive strontium competes with calcium for uptake into fetal and children's bones...," is in error. Strontium-90 does not<i>compete</i>with calcium for deposit in any sense of the word. The misconception arises from the fact that it is customary to express the amount of strontium-90 in food, bone, etc., in relation to calcium content. The unit most commonly used is the sunshine unit (SU): 1μμc of strontium-90 per gram of calcium. The choice of this unit does not imply a consistent relationship between strontium and calcium; the SU was chosen as a means of normalizing the intake of strontium in relation to a common element of the diet. In man there is some evidence that strontium-90 absorption is relatively less when the dietary calcium is relatively abundant, and vice versa. In general, however, the human
Erythropoietin and the Regulation of Erythropoiesis
Authors: Ward D. Noyes
Journal: JAMA (1970)

The profusion of data which has sprouted in the last 20 years on red blood cell (RBC) regulation is so phenomenal as to be frightening. We have passed from the speculation of a circulating humoral factor controlling hemoglobin synthesis to a highly developed model supported by clinical, animal, and biochemical evidence. Erythropoietin, found in plasma and urine, is produced in response to tissue hypoxia and within minutes accelerates RNA synthesis in RBC precursors. This humoral response to oxygen deficit occurs predominantly in the kidney where an enzyme found in the light mitochondrial fraction, in the presence of normal plasma, forms erythropoietin. Thus, the anemia of renal disease results largely from failure of the kidneys to synthesize this hormone whereas most cases of aplastic anemia are the result of failure of the marrow to respond to high circulating levels of erythropoietin. Krantz and Jacobson have taken the deluge of information and
Does helicobacter pylori infection have influence on outcome of laparoscopic sleeve gastrectomy for morbid obesity?
Authors: Gianluca Rossetti, Francesco Moccia, Teresa Marra, Mattia Buonomo, Beniamino Pascotto, Angelo Pezzullo, Vincenzo Napolitano, Pietro Schettino, Manuela Avellino, Giovanni Conzo, Bruno Amato, Giovanni Docimo, Salvatore Tolone, Gianmattia Del Genio, Ludovico Docimo, Landino Fei
Journal: International Journal of Surgery (2014)
Relation of the Electrocardiogram to Ventricular Function and Clinical Status in Ischemic Heart Disease.
Authors: Richard R. Miller
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Relation of the Electrocardiogram to Ventricular Function and Clinical Status in Ischemic Heart Disease.Richard R. Miller, M.D., James L. Hughes, M.D., Antone F. Salel, M.D., Rashid A. Massumi, M.D., Robert Zelis, M.D., Dean T. Mason, M.D., F.A.C.P., Ezra A. Amsterdam, M.D.Richard R. Miller, M.D.Search for more papers by this author, James L. Hughes, M.D.Search for more papers by this author, Antone F. Salel, M.D.Search for more papers by this author, Rashid A. Massumi, M.D.Search for more papers by this author, Robert Zelis, M.D.Search for more papers by this author, Dean T. Mason, M.D., F.A.C.P.Search for more papers by this author, Ezra A. Amsterdam, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-866_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe ECG has not been fully evaluated for its relation to ventricular function and clinical status. One-hundred and four patients with angina pectoris and documented coronary artery disease undergoing diagnostic cardiac catheterization (Group I) and 148 patients with acute myocardial infarction (Group II) were studied. In Group I, 48 patients without pathologic 0.04-sec Q waves (NQ) were compared with 17 with a history of remote inferior myocardial infarction (IQ), 28 with remote anterior-inferior myocardial infarction (AIQ). Findings were as follows left ventricular end-diastolic pressure (LVEDP): NQ 11, IQ 11, AQ 17 (P< 0.005), AIQ 25 mm Hg (P<... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Davis, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPump dysfunction after myocardial infarction: Importance of location, extent and pattern of abnormal left ventricular segmental contraction 1 May 1972Volume 76, Issue 5Page: 866-866KeywordsAcute myocardial infarctionAnginaCardiovascular therapyCatheterizationElectrocardiographyHeart diseasesMyocardial infarctionStable coronary artery disease ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Impairment of Diazepam Metabolism by Low-Dose Estrogen-Containing Oral-Contraceptive Steroids
Authors: Darrell R. Abernethy, David J. Greenblatt, Marcia Divoll, Rainer Arendt, Herman R. Ochs, Richard I. Shader
Journal: New England Journal of Medicine (1982)

The longterm use of low-dose estrogen containing oral contraceptives (OCs) and its impairment of diazepam clearance is reported. 8 healthy women, ranging in age from 52 to 72 years, participated in the study. All of the women had been taking low-dose estrogen containing OCs for more than 3 months. 1 of the subjects was a cigarette smoker. 8 healthy controls (all nonsmokers) who were not using OCs also participated. They ranged in age from 27-31 years. Diazepam (10 mg) was given by intravenous infusion over 15-30 seconds. Venous blood samples were drawn into heparinized tubes before the infusion, at the end of the infusion, at 5, 15, 30, and 45 minutes, at 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12, and 24 hours, and daily for 7 days after the infusion. Plasma concentrations of diazepam after intravenous infusion were analyzed by weighted iterative nonlinear least-squares regression techniques. The volume of distribution of diazepam was not significantly different between the groups, but the apparent elimination half-life of diazepam was significantly longer and the total metabolic clearance significantly less in the OC users than in the control group. The differences were not confounded by variations in protein binding. The mean diazepam free fraction was identical in the 2 groups. The clinical result of the decrease in diazepam clearance reported here would be increased steady-state plasma diazepam concentration after longterm use at a given daily dose, with the potential for increasing the clinical effects of diazepam in this population.
Clinical course of reverse redistribution on Thallium-210 myocardial SPECT in patients with myocardial infarction
Authors: Kazuya Takehana, Tetsuro Sugiura, Yoshiteru Abe, Kengo Hatada, Sachiyo Okugawa, Seishi Nakamura, Toshiji Iwasaka
Journal: Journal of the American College of Cardiology (1998)
Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells
Authors: Katia Basso, Masumichi Saito, Pavel Sumazin, Adam A. Margolin, Kai Wang, Wei-Keat Lim, Yukiko Kitagawa, Christof Schneider, Mariano J. Alvarez, Andrea Califano, Riccardo Dalla-Favera
Journal: Blood (2009)
Muriel Frances (“Mona”) Prout
Authors: J M Chalmers
Journal: BMJ (2004)

​FormerFormer general practitioner Bromley (b 1903; q Royal Free Hospital, London, 1926; MD), died from bronchopneumonia on 20 May 2004.




Figure 1




Mona became an assistant in and around London before buying a singlehanded practice in Bromley. During the second world war she took on the work of other general practitioners who had been called up and she also ran a casualty station from her home. She became a GP trainer in 1948. Always a music lover, landscape painter, and keen gardener, after retiring in 1967 she and her brother Hugh lived happily together for many years. He predeceased her. A great supporter of charitable work she was still helping in her local Oxfam shop in her late 90s.
Antibiotics and Nasal Steroids for Acute Sinusitis
Authors: Eli O. Meltzer
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Non-enrolment of ovarian cancer patients in clinical trials: reasons and background
Authors: P. Harter, A. du Bois, C. Schade-Brittinger, A. Burges, K. Wollschlaeger, M. Gropp, B. Schmalfeldt, J. Huober, A. Staehle, J. Pfisterer
Journal: Annals of Oncology (2005)
Treating Breast Cancer: The Age Old Dilemma of Old Age
Authors: Jeanne Mandelblatt
Journal: Journal of Clinical Oncology (2006)

Women 65 years or older (hereafter referred to as older women) constitute half of the new breast cancer patients each year, and the absolute number of patients will double by 2030 with the "graying of America."Despite their large numbers, over the past several decades, when older women develop breast cancer, they fail to receive care consistent with prevailing guidelines. 1,2Reasons for the divergence of care from professional recommendations may be partially explained by the lack of clinical trial data for this age group, uncertainty about the balance of treatment toxicity and benefits, differential access, the potential for therapy to amplify pre-existing medical conditions, and the effects of competing noncancer causes of mortality.There is also minimal data on older women's preferences for treatment and its outcomes. 3n this issue of the Journal of Clinical Oncology, Enger et al 4 use a population of older women from a well-defined managed care research network to underscore the fact that, whatever the reason, increasing age was associated with receipt of nonstandard breast cancer care in the early 1990s, even after considering comorbidity, tumor factors, and other variables.Most prior studies on this topic have been performed using the Surveillance, Epidemiology, and End Results (SEER) and SEER-Medicare databases 1 and convenience cohorts. 2 This new study is unique in that it draws the same conclusion among women cared for in large equal-access systems.This work was facilitated by the development of the Cancer Research Network, a National Cancer Institute-funded collaboration between 12 large, mature managed care systems, including Group Health Cooperative, the Harvard Pilgrim Health Plan, Henry Ford Health Systems, Fallon Community Health Plan, and Kaiser Permanente in six regions. 5Managed care research networks have several potential advantages for studying the quality of cancer care.First, access is removed from the equation in examining age and other disparities.Second, they include large proportions of the population from almost all regions of the United States, providing an alternative universe for population-based studies.Third, the availability of computerized administrative databases linked to laboratory and pathology data and often electronic medical records provides more comprehensive, cost-efficient clinical data than the data available in SEER or Medicare claims.Regardless of setting, this study joins a large body of literature that suggests that age bias plays a significant role in the persistent undertreatment of older women over time.For instance, older women who perceive more ageism in their interactions with providers are less likely to receive radiation or chemotherapy. 6What