tbuckley/cabot-search huggingface dataset:
THREE CASES OF EXTRA-UTERINE PREGNANCY.ONE BEING COINCIDENT WITH NORMAL UTERINE PREGNANCY, AND ONE BEING A CASE OF ABDOMINAL PREGNANCY-OPERATION AND RECOVERY IN ALL. Read before the Union Medical Association of Northeastern, Ohio, at Akron, Ohio, Aug. 8,1893.
Authors: J. A. DICKSON
Journal: JAMA (1894)

<i>Case 1</i>.—On Sept. 18, 1891, I was called by telegram to see Miss S., with the injunction to come by daylight in the morning, prepared to operate. I found my patient to be a young girl 18 years old and unmarried, with the history of suppressed menstruation for two periods. Two weeks before the time for the third period she was seized with abdominal pain and uterine colic, with a profuse discharge of clotted and shreddy blood, which was supposed to be a return of the long delayed menstrual flow. This peculiar flow continued for two weeks, but its long continuation was not a source of anxiety to patient or friends, on account of the long delayed menstruation. On the 18th, one week after the cessation of the flow, she rode fourteen miles, over a rough road in a huge Pennsylvania wagon. She was seized that night with terrific abdominal
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
Authors: Zuoning Han, David L. Boyle, Lufen Chang, Brydon Bennett, Michael Karin, Li Yang, Anthony M. Manning, Gary S. Firestein
Journal: Journal of Clinical Investigation (2001)

Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun N-terminal kinase (JNK) is highly activated in RA fibroblast-like synoviocytes and synovium. However, defining the precise function of this kinase has been difficult because a selective JNK inhibitor has not been available. We now report the use of a novel selective JNK inhibitor and JNK knockout mice to determine the function of JNK in synoviocyte biology and inflammatory arthritis. The novel JNK inhibitor SP600125 (anthra[1,9-cd]pyrazol-6(2H)-one) completely blocked IL-1--induced accumulation of phospho-Jun and induction of c-Jun transcription in synoviocytes. Furthermore, AP-1 binding and collagenase mRNA accumulation were completely suppressed by SP600125. In contrast, complete inhibition of p38 had no effect, and ERK inhibition had only a modest effect. The essential role of JNK was confirmed in cultured synoviocytes from JNK1 knockout mice and JNK2 knockout mice, each of which had a partial defect in IL-1--induced AP-1 activation and collagenase-3 expression. Administration of SP600125 modestly decreased the rat paw swelling in rat adjuvant-induced arthritis. More striking was the near-complete inhibition of radiographic damage that was associated with decreased AP-1 activity and collagenase-3 gene expression. Therefore, JNK is a critical MAPK pathway for IL-1--induced collagenase gene expression in synoviocytes and in joint arthritis, indicating that JNK is an important therapeutic target for RA.
The BB-isoenzyme is a major component of creatine kinase in skin blister fluid
Authors: T. PAAVONEN, H. ARONEN, I. SAARELAIKEN, H. NEITTAANMAKI, I. HJELM, U. KIISTALA
Journal: British Journal of Dermatology (1988)

We measured levels of creatine kinase and its three isoenzymes in serum and blister fluid from 16 healthy volunteers. The BB-isoenzyme was found to be the predominant form in blister fluid white only the MM isoenzyme was found in serum. The levels of BB-isoenzyme in blister fluid decreased as the blisters aged. The source of BB-isoenzyme in blister fluid is most probably the damaged epidermis.
Lesson of the week: Exacerbating cervical spine injury by applying a hard collar
Authors: M. C Papadopoulos, A. Chakraborty, G. Waldron, B A. Bell
Journal: BMJ (1999)

Hard collars should not be used for patients with fixed cervical kyphosis who break their neck.

Neck immobilisation is vital in patients with suspected cervical spine injuries and generally involves applying a hard cervical collar—usually by ambulance crew, nurses, or junior doctors. We present the case of a patient with ankylosing spondylitis who sustained a cervical fracture but had no cord injury initially. He became quadriplegic after a hard collar was applied in the emergency department, and he subsequently died.

An 82 year old man fell down some stairs. He walked into the emergency department, without cervical immobilisation, complaining of neck pain. He had longstanding spinal stiffness and, because of a fixed flexion deformity of his neck, his line of vision was only a few paces ahead. There was tenderness over the spinous processes of C6 and C7, but no neurological abnormality in his limbs or sphincter disturbance were noted. Radiographs of the cervical spine showed ossification across the intervertebral discs at several levels, suggesting ankylosing spondylitis, and …
Tendon Rupture Associated With Excessive Smartphone Gaming
Authors: Luke Gilman, Dori N. Cage, Adam Horn, Frank Bishop, Warren P. Klam, Andrew P. Doan
Journal: JAMA Internal Medicine (2015)

Excessive use of smartphones has been associated with injuries.A 29-year-old, right hand-dominant man presented with chronic left thumb pain and loss of active motion from playing a Match-3 puzzle video game on his smartphone all day for 6 to 8 weeks. On physical examination, the left extensor pollicis longus tendon was not palpable, and no tendon motion was noted with wrist tenodesis. The thumb metacarpophalangeal range of motion was 10° to 80°, and thumb interphalangeal range of motion was 30° to 70°. The clinical diagnosis was rupture of the left extensor pollicis longus tendon. The patient subsequently underwent an extensor indicis proprius (1 of 2 tendons that extend the index finger) to extensor pollicis longus tendon transfer. During surgery, rupture of the extensor pollicis longus tendon was seen between the metacarpophalangeal and wrist joints.The potential for video games to reduce pain perception raises clinical and social considerations about excessive use, abuse, and addiction. Future research should consider whether pain reduction is a reason some individuals play video games excessively, manifest addiction, or sustain injuries associated with video gaming.
Patient characteristics and clinical caseload of short stay independent hospitals in England and Wales, 1992-3
Authors: B T Williams, J P Nicholl
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objective</b>: To describe and quantify the patients and clinical activities of independent short stay hospitals. <b>Design</b>: Retrospective survey of hospital records for sampled periods of one financial year and comparison with data from 1981 to 1986. <b>Setting</b>: 217 independent hospitals in England and Wales, 1992-3. <b>Main outcome measures</b>: Distributions of sex, age groups, and areas of residence of patients, clinical procedures, financial provision. Results - Data were obtained fro 201 (93%) hospitals. An estimated 429 172 inpatients (7% more than 1986) and 249531 day cases (an increase of 154%) from 1986 were treated in the year. The number of overseas patients was half that in 1986. Clinical case mix remained similar to 1986. Abortion remained the commonest procedure (13% v 19% in 1986). Lens operations, heart operations, endoscopies, and non-surgical cases showed the largest increases from 1986. Proportionately more overseas patients had abortions (30% v 12% for England and Wales residents) and they received 41% of coronary artery bypass grafting. Three quarters of the patients were aged 15-64. The proportion of patients aged over 65 had changed little (19% v 17% in 1986). Estimated average bed occupancy was only 48%. Only one in 20 patients was treated under NHS contract; 90% of episodes were funded through private health insurance. <b>Conclusions</b>: The demand for treatment in private hospitals continues to increase despite additional investment in the NHS, but the overseas market is falling. Overall, the range of clinical activity has changed little.
Abstract 19281: Outcomes Following Cardioversion and Atrial Fibrillation Ablation in Patients Treated with Rivaroxaban and Warfarin in the ROCKET AF Trial
Authors: Jonathan P Piccini, Susanna Stevens, Yuliya Lokhnygina, Manesh Patel, Daniel Singer, Jonathan Halperin, Graeme Hankey, Werner Hacke, Richard Becker, Christopher Nessel, Kenneth Mahaffey, Keith Fox, Robert Califf, Gúnter Breithardt
Journal: Circulation (2012)

Background: There are limited data regarding cardioversion and atrial fibrillation (AF) ablation in patients receiving novel, oral anti-Xa inhibitors. Methods: We compared the incidence of electrical cardioversion (ECV), pharmacologic cardioversion (PCV), or AF ablation and subsequent outcomes in the ROCKET AF trial. Results: Over a median follow-up of 2.1 years, 143 patients underwent ECV, 142 underwent PCV, and 79 underwent catheter ablation. The rate of ECV, PCV, or AF ablation was 1.44 per 100 patient-years in the warfarin arm and 1.46 per 100 patient-years in the rivaroxaban arm. In the adjusted analysis, the incidences of stroke or systemic embolism (HR 1.04; 95% CI 0.46-2.33), cardiovascular death (HR 1.24; 95% CI 0.55-2.78), and all-cause death (HR 1.43; 95% CI 0.74-2.77) were not significantly different following ECV, PCV, or AF ablation. Hospitalization was increased following ECV, PCV, or AF ablation (HR 2.16; 95% CI 1.63-2.86), and there was no evidence of a differential effect by randomized treatment (p for interaction=0.90). Event counts were similar in the rivaroxaban- and warfarin-treated patients following ECV, PCV, or AF ablation, including stroke or systemic embolism or death from any cause (Figure). Conclusions: Despite an increase in hospitalization, there was no difference in long-term stroke rates or survival following cardioversion or AF ablation. Outcomes following cardioversion or ablation were similar in those treated with rivaroxaban or warfarin.
Fascicular conduction disturbances and ischemic heart disease: Adverse prognosis despite coronary revascularization
Authors: Timothy M. Bateman, Mason H. Weiss, Lawrence S.C. Czer, Carolyn M. Conklin, Robert M. Kass, Morgan E. Stewart, Jack M. Matloff, Richard J. Gray
Journal: Journal of the American College of Cardiology (1985)
Hybrid Nanotopographical Surfaces Obtained by Biomimetic Mineralization of Statherin‐Inspired Elastin‐Like Recombinamers
Authors: Yuping Li, Xi Chen, Artur J. Ribeiro, Eric D. Jensen, Kyle V. Holmberg, J. Carlos Rodriguez‐Cabello, Conrado Aparicio
Journal: Advanced Healthcare Materials (2014)

Modification of surfaces mimicking unique chemical and physical features of mineralized tissues is of major interest for obtaining biomaterials for replacing and regenerating biological tissues. Here, human salivary statherin‐inspired genetically engineered recombinamers (ELRs, HSS) on biomedical surfaces regulates mineralization to form an amorphous‐calcium‐phosphate (ACP) layer that reproduces the original substrate nanotopography. The HSS‐ELRs carry a statherin‐derived peptide with high affinity to tooth enamel. They are tethered to nanorough surfaces and mineralized using an enzyme‐directed process. A homogeneous layer of ACP‐minerals forms on HSS‐coated surfaces retaining the original nanotopography of the substrate. In contrast, biomineralization of control surfaces results in uncontrolled growth of minerals. This suggest the statherin‐inspired ELRs have ability to induce and control growth of the minerals on the biofunctional surfaces. Likely, the HSS‐ELR coating have similar bioactivity to that of statherin in human saliva. The hybrid nanorough surfaces improve adhesion and differentiation of preosteoblasts and show potential for dental and orthopedic implants integration. This method enables the combination and tailoring of nanotopographical and biochemical cues to design functionalized surfaces to investigate and potentially direct the stem cell fate.
Colonoscopy, tumors and inflammatory bowel disease
Authors: D. Hurlstone
Journal: Endoscopy (2007)

Previous studies have prospectively evaluated the efficacy of high-magnification chromoscopic colonoscopy (HMCC) and endoscopic mucosal resection (EMR) for the detection and treatment of sporadic adenomas and early neoplastic colorectal lesions [1]. However, the management and clinical interpretation of dysplasia in the context of chronic ulcerative colitis (CUC) is radically different to that of sporadic dysplastic lesions in the “normal” population [2] [3]. At the current time, dysplasia is the most reliable biomarker of malignant change, being present in over 70 % of CUC patients with colorectal cancer [4]. Emerging data suggest that intraepithelial neoplasia (IN) is easily missed using conventional “white light” colonoscopy and current colorectal cancer (CRC) screening protocols. Emerging data now also suggest that simple polypectomy of adenoma-like mass (ALM) may be an adequate endoluminal therapy for CRC secondary prevention in this group - a radical paradigm shift away from total colectomy [5]. Furthermore, colonoscopy with mucosal biopsy, currently considered the “gold standard” investigation for the evaluation of disease activity and extent in ulcerative colitis (an important risk factor for IN development in CUC), may now be accurately predicted in vivo using high magnification chromoscopic techniques (HMCC) [6].
Hazards of Anticoagulation Therapy Shortly After Lumbar Puncture
Authors: Kamal Sadjadpour
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Although the risks of lumbar puncture in patients who are receiving anticoagulant therapy is now sufficiently recognized, a note of caution is required for patients who are to receive such therapy shortly after a lumbar puncture. <h3>Report of a Case.—</h3> A woman, aged 61 years, was admitted to the hospital for pulmonary emboli and a stroke, manifested by left hemiparesis. The latter was considered to be of brain stem origin. Lumbar puncture was performed to rule out a hemorrhagic event, so that she could be placed on anticoagulant therapy for the pulmonary emboli. Two needle punctures were required because of some technical difficulty. The fluid was obtained atraumatically, however, and it contained only a few RBCs. Shortly after lumbar puncture, the patient was placed on a regimen of heparin sodium and warfarin sodium (Coumadin). During the next few days, the patient complained of persistent pain at the
The Feasibility Study of Carboplatin Plus Etoposide for Advanced Small Cell Lung Cancer with Idiopathic Interstitial Pneumonias
Authors: Yuji Minegishi, Hidehiko Kuribayashi, Kazuhiro Kitamura, Hideki Mizutani, Seiji Kosaihira, Tetsuya Okano, Masahiro Seike, Arata Azuma, Akinobu Yoshimura, Shoji Kudoh, Akihiko Gemma
Journal: Journal of Thoracic Oncology (2011)
Academic boycott of Israel: follow-up to the <i>BMJ</i> 's debate
Authors: Fiona Godlee
Journal: BMJ (2007)

The <i>BMJ </i>has been overwhelmed with readers9 responses to the debate and poll about whether there should be an academic boycott of Israel. Many of the responses criticised the <i>BMJ</i>9s decision to run the debate. Editor <b>Fiona Godlee</b> defends the decision. We also print a summary of the poll results by the <i>BMJ</i>9s features editor and an edited selection of the rapid responses
An Intervention Involving Traditional Birth Attendants and Perinatal and Maternal Mortality in Pakistan
Authors: Abdul Hakeem Jokhio, Heather R. Winter, Kar Keung Cheng
Journal: New England Journal of Medicine (2005)

There are approximately 4 million neonatal deaths and half a million maternal deaths worldwide each year. There is limited evidence from clinical trials to guide the development of effective maternity services in developing countries.We performed a cluster-randomized, controlled trial involving seven subdistricts (talukas) of a rural district in Pakistan. In three talukas randomly assigned to the intervention group, traditional birth attendants were trained and issued disposable delivery kits; Lady Health Workers linked traditional birth attendants with established services and documented processes and outcomes; and obstetrical teams provided outreach clinics for antenatal care. Women in the four control talukas received usual care. The primary outcome measures were perinatal and maternal mortality.Of the estimated number of eligible women in the seven talukas, 10,114 (84.3 percent) were recruited in the three intervention talukas, and 9443 (78.7 percent) in the four control talukas. In the intervention group, 9184 women (90.8 percent) received antenatal care by trained traditional birth attendants, 1634 women (16.2 percent) were seen antenatally at least once by the obstetrical teams, and 8172 safe-delivery kits were used. As compared with the control talukas, the intervention talukas had a cluster-adjusted odds ratio for perinatal death of 0.70 (95 percent confidence interval, 0.59 to 0.82) and for maternal mortality of 0.74 (95 percent confidence interval, 0.45 to 1.23).Training traditional birth attendants and integrating them into an improved health care system were achievable and effective in reducing perinatal mortality. This model could result in large improvements in perinatal and maternal health in developing countries.
Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study
Authors: Wolfgang Oertel, Claudia Trenkwalder, Heike Beneš, Luigi Ferini-Strambi, Birgit Högl, Werner Poewe, Karin Stiasny-Kolster, Andreas Fichtner, Erwin Schollmayer, Ralf Kohnen, Diego García-Borreguero
Journal: The Lancet Neurology (2011)
Characterization of Recombinant DNA Derived—Human Luteinizing Hormone In Vitro and In Vivo
Authors: James A. Simon
Journal: JAMA (1988)

The present data are the first, to our knowledge, to demonstrate the production feasibility of a commercially available medication of pure human luteinizing hormone from recombinant DNA technology (rechLH). The rechLH preparation achieved ovulation induction and corpus luteum support in the primate menstrual cycle. The observations described herein indicate the opportunity for significant improvement in the treatment of infertile women and men who require gonadal stimulation. Recombinant DNA—derived gonadotropin products, rechLH in this case, will have several therapeutic advantages compared with current medications extracted from urine. These advantages include (1) better reliability of an available supply of hormone and (2) improved treatment flexibility in determining the optimal dose ratio of follicle-stimulating hormone and luteinizing hormone or avoidance of the long-acting effects of human chorionic gonadotropin, as the needs of individual patients may dictate. (<i>JAMA</i>1988;259:3290-3295)
Multiple herpetic whitlow lesions in a patient with chronic lymphocytic leukemia
Authors: Edward Smith, James R. Hallman, Asha Pardasani, Amy McMichael
Journal: American Journal of Hematology (2002)

Abstract Herpetic whitlow, a herpes simplex virus infection involving the digits, most commonly presents as a vesicular eruption involving a single digit. Diagnosis of herpetic whitlow can usually be made with the history of exposure, the characteristic vesicular eruption, and a positive Tzank smear and/or viral culture. We describe a case of herpetic whitlow in a patient finishing 6 cycles of chemotherapy for refractory chronic lymphocytic leukemia that presented with a bilateral, multi‐digit, crusted eruption of the hands. This is an illustrative case of an immunocompromised host status altering appearance and course of cutaneous disease such that the history and physical exam alone may not help in diagnosing atypical presentations of herpetic infections. This case underscores the necessity for clinico‐histopathologic correlation. Am. J. Hematol. 69:285–288, 2002. © 2002 Wiley‐Liss, Inc.
Remitting Seronegative Symmetrical Synovitis With Pitting Edema
Authors: Jacob Zatuchni
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The article by McCarty et al<sup>1</sup>is of interest. My purpose here is to call attention to a commonly occurring condition, namely, carpal tunnel syndrome, that may produce similar findings of edema of the hands and feet—for which a regimen of nonsteroidal and other drugs may be of limited or no benefit. Although various diseases are mentioned for consideration in evaluating these findings, carpal tunnel syndrome is ignored. A recent patient of mine, an 85-year-old man, was thought to have early seronegative rheumatoid arthritis. Instead, it proved to be bilateral carpal tunnel syndrome and his symptoms were completely relieved by conventional local therapy. In the article by McCarty et al, case 4 is stated to have nocturnal dysesthesiae in the median nerve distribution of both hands, which suggests similar entrapment. Carpal tunnel syndrome may, of course, occur alone or in combination with other diseases, including rheumatoid
The impact of steatosis on baseline characteristic and end of treatment response for chronic hepatitis (C) genotype 4 patients treated with interferon
Authors: G. Esmat, M.K. Mohamed, M. Abdel Hamid, K. Zalata, H. Khatab, M. El Batanony, A.M. Abouzied, M. El Raziky, A.M. Shaheen, A. Ismail, G.T. Strickland, A. Fix, M. Sjogren
Journal: Journal of Hepatology (2003)
Alcohol and Motor Vehicle–Related Deaths of Children as Passengers, Pedestrians, and Bicyclists
Authors: Lewis H. Margolis
Journal: JAMA (2000)

The overall percentage of motor vehicle deaths associated with alcohol consumption declined between 1991 and 1996, but the risk of death due to alcohol-related crashes for children warrants analysis.To examine the association between alcohol use by drivers and mortality of children who were passengers, pedestrians, and bicyclists.Analysis of data from the Fatality Analysis Reporting System, a nationwide US registry of motor vehicle deaths, for 1991-1996.A total of 16,676 children younger than 16 years who were passengers, pedestrians, or bicyclists and whose death was due to a motor vehicle crash.Alcohol use by drivers involved in crashes in which children died, assessed by age and sex of the child and driver and type of crash.A total of 3310 deaths (19.9%) involved alcohol-related crashes. The percentage declined from 21.6% in 1991 to 17.8% in 1996. Considering only crashes in which the alcohol-use status of the child's driver was relevant, the decline was less marked, from 18.8% in 1991 to 15.1% in 1995, with an increase to 16.4% in 1996. Among crashes involving alcohol, the child's own driver had been drinking in 66.3% of cases, varying from 58.0% to 70.7% over time. Drivers younger than the legal drinking age of 21 years who had been drinking alcohol accounted for 30.3% of alcohol-related passenger deaths among children.While the overall percentage of alcohol-related motor vehicle deaths for children declined between 1991 and 1996, experiences for passengers, pedestrians, and bicyclists differ. Selected characteristics of children and drivers that elevate the risk of an alcohol-related motor vehicle death point to the need for further policy and clinical interventions.
(56) Hidradenomes eruptif
Authors: S.B. Bittiner, C.I. Harrington
Journal: British Journal of Dermatology (1986)

Journal Article (56) Hidradenomes eruptif Get access S.B. Bittiner, Drs, S.B. Bittiner, Drs Search for other works by this author on: Oxford Academic Google Scholar C.I. Harrington C.I. Harrington Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Page 98, https://doi.org/10.1111/j.1365-2133.1986.tb07751.x Published: 01 July 1986