tbuckley/cabot-search huggingface dataset:
"World Class" Physicians Get First US-Israeli Training
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The New Academic Medical Center
Authors: M C Creditor
Journal: New England Journal of Medicine (1990)

Creative Solutions Outrageous Perspectives on Problem Solving. We often look to logic instead of creativity for "true answers" to life's struggles. This workshop explores the creative process and teaches skills for problem solving. We will examine (1) fallacies of logical/rational thought; (2) benefits of metaphors; (3) ways to make thoughts public without language. Instructor: A.N. Onymous Fee: $10 Classroom: 5Risk Taking"Life is either a daring adventure or nothing at all," Helen Keller said. Are you ready to risk participation in this workshop? Learn how to evaluate risks, recognize the "true" moment of risk, build strategies for taking . . .
The value of a baseline liver biopsy prior to methotrexate treatment
Authors: O.M. DOLAN, D. BURROWS, A. IRVINE, M. WALSH
Journal: British Journal of Dermatology (1994)

Two patients with severe disabling psoriasis were treated with methotrexate (MTX). As a short course of treatment was envisaged, a pretreatment liver biopsy was not performed. Although both patients developed similarly abnormal levels of hepatic enzymes after low cumulative doses of MTX (440 and 450mg), subsequent liver biopsies revealed contrasting findings. In one patient the histological features were normal. However, in the second, there was hepatic fibrosis, and the absence of a pretreatment biopsy led to problems with interpretation of these histologivcal findings. As a liver biopsy is by far the most reliable method of detecting liver disease, we suggest that it is still of value to include a baseline liver biopsy in the pretreatment assessment of patients even when only a short course of MTX is planned.
Is severe cryptogenic chronic hepatitis similar to autoimmune hepatitis?
Authors: Sabahattin Kaymakoǧlu, Yilmaz Çakaloǧlu, Kadir Demir, Salih Türkoǧlu, Selim Badur, Selim Gürel, Fatih Beşışık, Uǧur Çevikbaş, Atilla Ökten
Journal: Journal of Hepatology (1998)
PWE-128 Surveillance Of Hepatocellular Carcinoma – Consistent Or Confused?
Authors: B Hudson, J Lee, JD Maltby
Journal: Gut (2014)

<h3>Introduction</h3> BSG guidelines for diagnosis and treatment of hepatocellular carcinoma (2003) advocate 6 monthly surveillance of high risk cirrhotic patients with abdominal ultrasonography and alfa-feto protein estimation. An audit of cirrhotic patients managed at the Royal United Hospital demonstrated poor compliance with BSG guidelines, with only 24.1% of eligible patients receiving regular 6 monthly surveillance over an 18 month period. Compliance was particularly poor amongst viral hepatitis patients who often failed to attend appointments. The current work explores whether the difficulties and inconsistencies noted on a local level are representative of wider practice, and considers ways in which barriers to optimum practice could be overcome. <h3>Methods</h3> Issues raised from a local audit (see above) informed design of an electronic questionnaire which assessed policy, clinician opinion, and response to various clinical scenarios. This was distributed to Gastroenterology/Hepatology consultants and STRs in the South West and Wales. <h3>Results</h3> 81 responses were received from 16 NHS trusts across the South West and Wales (42% response rate). 41% of respondents were consultants (59% gastroenterologists/41% hepatologists). 65.3% of respondents were familiar with BSG guidelines, however only 21.8% used them within their institution. 33% of respondents did not know which guidelines their department used. Widespread variation was noted in response to clinical scenarios. Whereas there was general agreement that 6 monthly surveillance should be afforded to patients with cirrhosis secondary to haemochromatosis and alcohol when abstinent (even amongst females which is not suggested in BSG guidelines), opinion was divided in respect to patients who continued to drink, and in those with non-cirrhotic chronic hepatitis B (47% would offer surveillance, 36% would not). Poor patient compliance and insufficient resources and expertise to co-ordinate surveillance programmes were cited as the main barriers to successful surveillance. 86% of respondents felt HCC surveillance could be improved within their institution, and 38% thought HCC surveillance programmes should be further extended given recent developments in palliative management. <h3>Conclusion</h3> Findings from this study would, if representative of wider practice, suggest considerable variations in HCC surveillance accross the UK currently exist. Low levels of compliance with and awareness of BSG guidelines were demonstrated. Opinion regarding optimum surveillance of certain pateint groups (e.g., non-cirrhotic viral hepatitis and alcoholic cirrhosis in females) was generally at odds with guidelines. Updating guidelines to account for recent changes in HCC management may help to achieve nationally consistent high quality HCC surveillance. Strategies for improving local HCC surveillance are discussed. <h3>Disclosure of Interest</h3> None Declared.
Generalized racemose livedo and neurological lesions
Authors: D. Lubach, T. Stamm
Journal: British Journal of Dermatology (1983)

Journal Article Generalized racemose livedo and neurological lesions Get access D. Lubach, D. Lubach Department of Dermatology, (Hautklinik Linden), Medizinische Hochschule Hannover, Ricklinger Str. 5 (3000) Hannover‐91, West Germany Search for other works by this author on: Oxford Academic Google Scholar T. Stamm T. Stamm Department of Dermatology, (Hautklinik Linden), Medizinische Hochschule Hannover, Ricklinger Str. 5 (3000) Hannover‐91, West Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 4, 1 April 1983, Page 501, https://doi.org/10.1111/j.1365-2133.1983.tb04605.x Published: 01 April 1983
Utility of routine viral load, CD4 cell count, and clinical monitoring among adults with HIV receiving antiretroviral therapy in Uganda: randomised trial
Authors: J. Mermin, J. P. Ekwaru, W. Were, R. Degerman, R. Bunnell, F. Kaharuza, R. Downing, A. Coutinho, P. Solberg, L. N. Alexander, J. Tappero, J. Campbell, D. M. Moore
Journal: BMJ (2011)

<b>Objective</b> To evaluate the use of routine laboratory monitoring in terms of clinical outcomes among patients receiving antiretroviral therapy (ART) in Uganda. <b>Design</b> Randomised clinical trial <b>Setting</b> A home based ART programme in rural Uganda. <b>Participants</b> All participants were people with HIV who were members of the AIDS Support Organisation. Participants had CD4 cell counts &lt;250 cells × 10<sup>6</sup>/L or World Health Organization stage 3 or 4 disease. <b>Interventions</b> Participants were randomised to one of three different monitoring arms: a viral load arm (clinical monitoring, quarterly CD4 counts, and viral load measurements), CD4 arm (clinical monitoring and CD4 counts), or clinical arm (clinical monitoring alone). <b>Main outcome measures</b> Serious morbidity (newly diagnosed AIDS defining illness) and mortality. <b>Results</b> 1094 participants started ART; median CD4 count at baseline was 129 cells × 10<sup>6</sup>/L. Median follow-up was three years. In total, 126 participants died (12%), 148 (14%) experienced new AIDS defining illnesses, and 61(6%) experienced virological failure, defined as two consecutive viral loads &gt;500 copies/mL occurring more than three months after the start of ART. After adjustment for age, sex, baseline CD4 count, viral load, and body mass index, the rate of new AIDS defining events or death was higher in the clinical arm than the viral load arm (adjusted hazard ratio 1.83, P=0.002) or the CD4 arm (1.49, P=0.032). There was no significant difference between the CD4 arm and the viral load arm (1.23, P=0.31). <b>Conclusion</b> In patients receiving ART for HIV infection in Uganda, routine laboratory monitoring is associated with improved health and survival compared with clinical monitoring alone. <b>Trial registration</b> Clinical Trials NCT00119093.
Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.
Authors: A Kratz, A Campos-Neto, M S Hanson, N H Ruddle
Journal: The Journal of Experimental Medicine (1996)

In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal and similar. Chronic inflammatory lesions that developed in the kidney and pancreas at the sites of transgene expression in rat insulin promoter-LT (RIP-LT) mice resembled lymph nodes with regard to cellular composition (T cells, B cells, plasma cells, and antigen-presenting cells), delineated T and B cell areas, primary and secondary follicles, characteristic morphologic and antigenic (ICAM-1, VCAM-1, MAdCAM-1, and PNAd) features of high endothelial venules, and ability to respond to antigen and undergo Ig class switching when obtained from mice immunized with SRBC. The vascular changes, with the exception of PNAd, appear to be the direct consequence of transgene derived LT expression, as they were also observed in RIP-LT mice lacking mature T and B cells. These data show that LT-induced chronic inflammation has the characteristics of organized lymphoid tissue.
Medical students and smoking.
Authors: J. Anderson
Journal: BMJ (1970)

Life in FlatsSIR,-Your leading article on life in flats (19 September, p. 661) rightly stresses the disadvantages for inhabitants of modern tower blocks, particularly for families with young children.It would, however, be quite wrong to think that these are the only rehoused families who suffer social and geo- graphical isolation.It would also be quite wrong to draw any conclusions as to aetiology of their unhappiness or ill-health by studying families only in the new environment.Published studies on the effect of rehousing on the health of the individual or family unit are few, but the major studies into the psychiatric aspects"-4 all agreed that the prevalence of neurotic illness was the same in new towns as in other comparable populations in older urban areas.It was further shown that individuals suffering with psy- chiatric symptoms attributable to the new environment were similarly troubled before rehousing, and would therefore be regarded as vulnerable personalities.My own study into the situation in Salford' confirmed this latter finding.While not in any way wishing to discour- age the immediate implementation of the suggestions of the N.S.P.C.C. report,6 which would undoubtedly improve the living con- ditions for young families, it would be quite wrong to draw any conclusions from the report as to the effect on health as opposed to happiness.-Iam, etc.,
878-2 Oral rapamycin in patients undergoing coronary stent therapy: Final results of the ORAR study (Oral Rapamycin in Argentina)
Authors: Alfredo E Rodriguez, Máximo Rodriguez Alemparte, Carlos Fernandez Pereira, César F Vigo, Claudio Llauradó, Miguel Russo Felsen, Antonio Pocovi, David Vetcher
Journal: Journal of the American College of Cardiology (2004)
Predictive factors for the outcome of allogeneic transplantation in patients with MDS stratified according to the revised IPSS-R
Authors: Matteo G. Della Porta, Emilio Paolo Alessandrino, Andrea Bacigalupo, Maria Teresa van Lint, Luca Malcovati, Cristiana Pascutto, Michele Falda, Massimo Bernardi, Francesco Onida, Stefano Guidi, Anna Paola Iori, Raffaella Cerretti, Paola Marenco, Pietro Pioltelli, Emanuele Angelucci, Rosi Oneto, Francesco Ripamonti, Paolo Bernasconi, Alberto Bosi, Mario Cazzola, Alessandro Rambaldi
Journal: Blood (2014)
Idiopathic scoliosis. Mechanical properties of the respiratory system and the ventilatory response to carbon dioxide.
Authors: E R Kafer
Journal: Journal of Clinical Investigation (1975)

The aims were to examine the effects of scoliosis (angle), and age on lung volumes, elastic properties of the respiratory system, and the ventilatory response to CO2. The mean age of the 55 patients was 25.4 plus or minus SEM 2.5 yr, and the mean angle was 80 plus or minus SEM 4.2. The mean plus or minus SEM percent predicted lung volumes were vital capacity (VC), 60.5 plus or minus 2.7; total lung capacity (TLC), 70,2 plus or minus 2.6; functional residual capacity (frc), 79.3 plus or minus 3.2; and residual volume (RV), 99.7 plus or minus 5.2. The correlation coefficients between the angle of scoliosis and each of the following were significant: TLC (-0.548), percent predicted TLC (-0.547), VC (-0.485), percent predicted VC (-0.523), FRC (-0.533), percent predicted FRC (-0.338), RV (-0.438), and percent predicted RV (-0.318). The mean compliance of the total respiratory system (Crs) was 0.049 litter/cm H2O plus or minus SEM 0.004, and the mean compliance of the chest wall (Ccw) was 0.080 liter/cm H2O plus or minus SEM 0.012. The Crs and Ccw were inversely proportional to the angle (r-0.620 and -0.721) and directly proportional to the height and the weight. The mean deltaV/deltaPco2 was 1.32 liter/min per mm Hg (SEM 0.171), and the mean deltaVt/deltaPco2 was 28.9 ml/mm Hg (SEM 3.64). The correlation coefficients between deltaV/deltaPco2 and the following were height, 0.499; VC, 0.792; TLC, 0.632; AND Crs, 0.520; and between the deltaTt/deltaPco2 and the following were height, 0.500; VC, 0.878; TLC, 0.802; and Crs, 0.590. We conclude that body size and the deformity were the determinants of the lung volumes and the mechanical properties of the respiratory system, and that these variables were the major factors in both the magnitude and pattern of the ventilatory response to CO2. The correlations between age and the mechanical properties of the respiratory sytem, deltaV/deltaPco2, and deltaVt/deltaPco2, were not significant, but the correlation coefficients between age and several of the derivatives of deltaV/deltaPco2 and deltaVt/deltaPco2 were significant.
Halothane and Liver Dysfunction: a Retrospective Study
Authors: W. W. Mushin, M. Rosen, D. J. Bowen, H. Campbell
Journal: BMJ (1964)

This investigation was undertaken because of the number of reports during the last six years suggesting that halothane has hepatotoxic properties.In 1958 Virtue and Payne described a patient who became jaundiced and died after a cholecystectomy under halothane- nitrous-oxide anaesthesia.At necropsy the cause of death was shown to be necrosis of the liver and pancreas.Halothane was not directly blamed because the treatment of this patient included measures which might equally well have been responsible for the liver damage.In the same year Burnap et al. (1958) described two patients, one of whom died with necrosis of the liver, and the other developed post-necrotic cirrhosis of the liver, but recovered.Both patients had halo- thane anaesthesia.Other reports followed of cases of suspected liver damage associated with halothane (Barton, 1959; Vourc'h et al.
Clinical Depression Versus Distress Among Patients With Type 2 Diabetes: Not Just a Question of Semantics
Authors: Salvador Vale
Journal: Diabetes Care (2007)

Fisher et al. (1) showed several ambiguities in the current meaning of depression. Individuals who feel saddened or unhappy by virtue of life's vicissitudes meet criteria for major depressive disorder (MDD) if these moods are associated with decreased energy or interest. Such imprecision is the result of a historical anomaly: In 1980, the Diagnostic and Statistical Manual of Mental Disorders (DSM)-III amalgamated a collection of depressive disorders and syndromes (2 …
Selected New Books
Authors: Edwin Quinn
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease
Authors: Dominick J. Angiolillo, Steven B. Shoemaker, Bhaloo Desai, Hang Yuan, Ronald K. Charlton, Esther Bernardo, Martin M. Zenni, Luis A. Guzman, Theodore A. Bass, Marco A. Costa
Journal: Circulation (2007)

After treatment with clopidogrel, patients with type 2 diabetes mellitus (T2DM) have reduced platelet inhibition compared with patients who are not diabetic. Whether platelet inhibition can be enhanced by increasing clopidogrel maintenance dosage in T2DM patients is unknown. The aim of this pilot study was to assess the functional impact of a high maintenance dose in T2DM patients with suboptimal clopidogrel-induced antiplatelet effects.T2DM patients on chronic dual antiplatelet therapy were screened to identify suboptimal clopidogrel responders. The latter were randomized to 30-day treatment with a standard (75 mg; n=20) or high (150 mg; n=20) daily maintenance dose. Platelet function was assessed at 3 time points: baseline, 30 days after randomization, and 30 days after resuming standard dosing. Platelet function parameters included adenosine diphosphate-induced (20 and 5 micromol/L) maximal and late platelet aggregation, inhibition of platelet aggregation, platelet disaggregation, and P2Y12 reactivity index. A total of 64 T2DM patients were screened to identify 40 suboptimal responders. After randomization, maximal adenosine diphosphate-induced (20 micromol/L) platelet aggregation was significantly reduced in the 150-mg group compared with the 75-mg group (P=0.002; primary end point). However, suboptimal clopidogrel response was still present in 60% of patients on the 150-mg regimen. All other platelet function parameters showed enhanced clopidogrel-induced antiplatelet effects with 150 mg, which returned to baseline values after resumption of standard dosing.A 150-mg maintenance dose of clopidogrel is associated with enhanced antiplatelet effects compared with 75 mg in high-risk T2DM patients. However, enhanced ex vivo platelet reactivity continues to persist, the clinical implications of which are unknown and need to be evaluated in large-scale clinical trials.
THE TREATMENT OF VISCERAL SYPHILIS
Authors: ALBERT KEIDEL
Journal: JAMA (1924)

The term visceral syphilis is generally employed as a pathologic notation covering a wide but not sharply defined anatomic field. In this discussion, it is used to designate syphilitic disease of any of the viscera of the thorax, abdomen, pelvis and scrotum. The pathogenesis of syphilis in this particular field does not differ from that of the disease as a whole; the early general dissemination of<i>Spirochaeta pallida</i>involves these structures simultaneously with those in other parts of the body, but these tissue groups do appear to differ from others in the degree of susceptibility and reactivity to the invading organism. This assumption is based largely on the frequency with which visceral syphilis appears late in the course of the disease, and the extreme infrequency with which it becomes a clinical feature of early syphilis. The existence of an exudative type of syphilitic inflammatory reaction in the viscera during the
Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes
Authors: Stacey M Glasgow, Wenyi Zhu, C Claus Stolt, Teng-Wei Huang, Fuyi Chen, Joseph J LoTurco, Jeffrey L Neul, Michael Wegner, Carrie Mohila, Benjamin Deneen
Journal: Nature Neuroscience (2014)
THE EFFECT OF HIGH SPINAL ANESTHESIA ON THE RENAL HEMODYNAMICS AND THE EXCRETION OF ELECTROLYTES DURING OSMOTIC DIURESIS IN THE HYDROPENIC NORMAL PREGNANT WOMAN 1
Authors: N. S. Assali, S. A. Kaplan, S. J. Fomon, R. A. Douglass, Y. Tada
Journal: Journal of Clinical Investigation (1951)

In previous papers (1, 2) it was demonstrated that the normal pregnant woman subjected to autonomic blockade with high spinal anesthesia develops a marked fall in blood pressure leading to a shock-like state.Since the blood flow to the kidneys constitutes approximately one quarter of the total cardiac output under resting conditions, it seemed that a study of the renal hemodynamics under high spinal anesthesia might afford the opportunity of examining the response of an important part of the vascular bed to this procedure.Concurrently with the study of renal hemody- namics it was considered of some interest to ex- tend the observations to the excretion of sodium, chloride and potassium.The relationship between renal hemodynamics and electrolyte excretion is at present controversial, and it was thought likely that additional information regarding this relation- ship might be derived from the present study.In order to examine the response of the kidneys to this type of autonomic blockade, it was neces- sary to use a technique which would be applicable to a period of study of short duration.Thus the immediate response to spinal anesthesia could be followed and observations continued until the blood pressure had almost returned to levels preceding the injection of the spinal anesthetic.Previous studies (3-5) employing osmotic diuresis with hypertonic mannitol solution in hydropenia, had shown that this technique was applicable to a short