Granulomatous Hepatitis: A Hypersensitivity Response to Procainamide
Authors: HESCHI H. ROTMENSCH
Journal: Annals of Internal Medicine (1978)

Brief Reports1 November 1978Granulomatous Hepatitis: A Hypersensitivity Response to ProcainamideHESCHI H. ROTMENSCH, M.D., ISRAEL YUST, M.D., YARDENA SIEGMAN-IGRA, M.D., MEIR LIRON, M.D., BIANCA ILIE, M.D., NURITH VARDINON, Ph.D.HESCHI H. ROTMENSCH, M.D.Search for more papers by this author, ISRAEL YUST, M.D.Search for more papers by this author, YARDENA SIEGMAN-IGRA, M.D.Search for more papers by this author, MEIR LIRON, M.D.Search for more papers by this author, BIANCA ILIE, M.D.Search for more papers by this author, NURITH VARDINON, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-646 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAdverse side effects of procainamide have been the subject of many reports, with emphasis on the lupus-type syndrome that commonly occurs after prolonged exposure to the drug (1). Febrile reactions and chills are uncommon manifestations of procainamide hypersensitivity and appear within 1 to 2 weeks after the first dose in a nonsensitized person (2). Hepatitis associated with procainamide is an even less common complication of this agent and has been described in two instances (3, 4). In neither of these cases was a liver biopsy done.We report here the case of a patient who developed fever, chills, and a...References1. GOODMANGILMAN LA: The Pharmacological Basis of Therapeutics, 5th ed. New York, Macmillan Co., 1975, pp. 694-696 Google Scholar2. EL SHAHAWYFLOWERS MN: Unexplained fever and chills associated with myocardial infarction. Chest 62:263-265, 1972 CrossrefMedlineGoogle Scholar3. KINGBLOUNT JR: An unexpected reaction to procainamide. JAMA 186:603-604, 1963 CrossrefMedlineGoogle Scholar4. FARBER H: Fever, vomiting, and liver dysfunction with procainamide therapy. Postgrad Med 56:155-156, 1974 CrossrefMedlineGoogle Scholar5. DREYFUSSHELLMANKLOPSTOCKSCHWARTZVARDINON FMAJN: The basophil degranulation test in patients hypersensitive to drugs. Acta Allergol (Kbh) 21:17-24, 1965 CrossrefGoogle Scholar6. KURITZKYLIVNIMUNITZENGLANDERTYANOWIJSENBECKJOSHUAKOTT AEHTSHHE: Cell-mediated immunity to human myelin basic protein in schizophrenic patients. J Neurol Sci 30:369-373, 1976 CrossrefMedlineGoogle Scholar7. DOUGLAS S: Electron microscopic and functional aspects of human lymphocyte response to mitogens. Transplant Rev 11:39-59, 1972 MedlineGoogle Scholar8. CHAJEKLEHRERGELTNERLEVIJ TBDI: Quinidine-induced granulomatous hepatitis. Ann Intern Med 81:774-776, 1974 LinkGoogle Scholar9. ISHIZAKAISHIZAKAMENZEL KTA: Physicochemical properties of reaginic antibody. VI. Effect of heat on γ E-, γ G- and γ A-antibodies in the sera of ragweed sensitive patients. J Immunol 99:610-618, 1967 MedlineGoogle Scholar10. SPECTORHEESOM WN: The production of granulomata by antigen-antibody complexes. J Pathol 98:31-39, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HESCHI H. ROTMENSCH, M.D.; ISRAEL YUST, M.D.; YARDENA SIEGMAN-IGRA, M.D.; MEIR LIRON, M.D.; BIANCA ILIE, M.D.; NURITH VARDINON, Ph.D.Affiliations: Tel Aviv Municipal-Governmental Medical Center Sackler School of Medicine Tel Aviv University Tel Aviv Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs and ToxinsHepatotoxicity of Cardiovascular and Antidiabetic DrugsGranulomatous Diseases of the LiverGranulomas in the liverHepatotoxicity of Cardiovascular DrugsDrug-induced “Allergic hepatitis”Possible Case of Procainamide-Induced Intrahepatic Cholestatic JaundiceHypersensitivity reaction associated with acute hepatic dysfunction following a single intravenous dose of procainamideDrug Metabolism by Leukocytes and Its Role in Drug-Induced Lupus and Other Idiosyncratic Drug ReactionsAcute Drug-Induced Hepatic InjuryGranulomatous Liver Disease: Clinical AspectsChemical Manipulation of Desiccation and Defoliation and Essential Aspects for the Application and Development of New Chemical Compounds in the Future11 Drug-induced and toxic granulomatous hepatitisDrug effects on the liverDrugs and Liver Disease: A Tabular Compilation of Drugs and the Histopathological Changes That Can Occur in the LiverCase Report Fatal Methyldopa — Associated Granulomatous Hepatitis and MyocarditisDrug effects on the liver 1 November 1978Volume 89, Issue 5_Part_1Page: 646-647KeywordsAdverse reactionsBiopsyFeversHepatitisHepatitis AHypersensitivityLiver ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...