Hydrogen Ion Turnover in Health and in Renal Disease
Authors: J. RUSSELL ELKINTON
Journal: Annals of Internal Medicine (1962)

Review1 October 1962Hydrogen Ion Turnover in Health and in Renal DiseaseJ. RUSSELL ELKINTON, M.D., F.A.C.P.J. RUSSELL ELKINTON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-4-660 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn no field of biology and medicine is confusion more rampant and conceptual clarity more difficult to attain than in the field of acid-base equilibrium. This has been due to a variety of confusions: confusion between various terminologies and concepts, confusion between the concentration of free ionized hydrogen and the amounts of total potentially ionizable hydrogen in the buffer systems of the body, confusion between the events of transient and of steady states. In addition, some questions remain concerning the relative roles of the several intrarenal processes involved in the defective excretion of hydrogen ion in various types of diseased...References1. ELKINTON JR: The kidney and hydrogen ion metabolism, in Modern Problems in Pediatrics, Vol. VI, Karger, Basel and New York, 1960, p. 99. Google Scholar2. GAMBLEROSSTISDALL JLGSFF: The metabolism of fixed base during fasting. J. Biol. Chem. 57: 633, 1923. CrossrefGoogle Scholar3. CHRISTENSEN HN: Anion-cation balance? Univ. Mich. Med. Bull. 22: 163, 1956. Google Scholar4. CHRISTENSEN HN: Diagnostic Biochemistry, Oxford University Press, New York, 1959, 291 pp. Google Scholar5. RELMAN AS: Editorial. What are "acids" and "bases"? Amer. J. Med. 17: 435, 1954. CrossrefMedlineGoogle Scholar6. KAUFMANROSEN HESW: Clinical acid-base regulation—the Bronsted schema. Surg. Gynec. Obstet. 103: 101, 1956. MedlineGoogle Scholar7. 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Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Chemical Section of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.Presented in part as the Fourth Annual Basic Science Lecture of the Southern California Region of The American College of Physicians, November 1, 1961. Some of this material has been published in an earlier European review (1).Requests for reprints should be addressed to J. R. Elkinton, M.D., Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia 4, Pennsylvania. 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WINTERS, M.D.Uremic acidosis: Some alternative viewsRenal Acidosis: Diagnosis and Treatment 1 October 1962Volume 57, Issue 4Page: 660-685KeywordsAttentionExcretionGeneticsRenal diseases Issue Published: 1 October 1962 PDF DownloadLoading ...