Effects of Excessive Fructose Intake on Health
Authors: Richard J. Johnson, Miguel A. Lanaspa, Carlos Roncal-Jimenez, Laura G. Sanchez-Lozada
Journal: Annals of Internal Medicine (2012)

Letters19 June 2012Effects of Excessive Fructose Intake on HealthRichard J. Johnson, MD, Miguel A. Lanaspa, PhD, Carlos Roncal-Jimenez, BS, and Laura G. Sanchez-Lozada, PhDRichard J. Johnson, MDFrom University of Colorado, Denver, Aurora, CO 80045, and INC Ignacio Chavez, 14080 Mexico City, Mexico.Search for more papers by this author, Miguel A. Lanaspa, PhDFrom University of Colorado, Denver, Aurora, CO 80045, and INC Ignacio Chavez, 14080 Mexico City, Mexico.Search for more papers by this author, Carlos Roncal-Jimenez, BSFrom University of Colorado, Denver, Aurora, CO 80045, and INC Ignacio Chavez, 14080 Mexico City, Mexico.Search for more papers by this author, and Laura G. Sanchez-Lozada, PhDFrom University of Colorado, Denver, Aurora, CO 80045, and INC Ignacio Chavez, 14080 Mexico City, Mexico.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-12-201206190-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The review by Sievenpiper and colleagues (1) has the great potential for being taken to mean that excessive intake of fructose is safe and does not promote long-term weight gain, which should be interpreted with great caution. For example, one would not expect to see a difference in weight gain for any food if both control and treatment contain the same number of calories. The way fructose increases weight gain is by altering appetite, such that it stimulates increased food intake, by inducing leptin resistance or by direct effects on the brain (2, 3). However, if food ...References1. Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, et al. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med. 2012;156:291-304. [PMID: 22351714] LinkGoogle Scholar2. Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1370-5. [PMID: 18703413] CrossrefMedlineGoogle Scholar3. Cha SH, Wolfgang M, Tokutake Y, Chohnan S, Lane MD. Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci U S A. 2008;105:16871-5. [PMID: 18971329] CrossrefMedlineGoogle Scholar4. Hill JO, Peters JC, Wyatt HR. Using the energy gap to address obesity: a commentary. J Am Diet Assoc. 2009;109:1848-53. [PMID: 19857625] CrossrefMedlineGoogle Scholar5. Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, et al. Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev. 2009;30:96-116. [PMID: 19151107] CrossrefMedlineGoogle Scholar6. Malik VS, Popkin BM, Bray GA, Després JP, Willett WC, Hu FB. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care. 2010;33:2477-83. [PMID: 20693348] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Colorado, Denver, Aurora, CO 80045, and INC Ignacio Chavez, 14080 Mexico City, Mexico.Disclosures: Dr. Johnson: Board membership: Amway Scientific Board, Gatorade Museum Board; Consultancy: Ardea, Astellas, Danone, Novartis; Employment: University of Colorado, University of Florida; Expert testimony: expert on kidney diseases; Grants/grants pending (money to institution): Amway, Cardero, Danone, Questcor, Sugar Foundation; Payment for lectures including service on speakers bureaus: honoraria associated with lectures to universities or societies; Patents (planned, pending or issued): have patent applications on blocking fructose metabolism or lowering uric acid as a means for preventing or treating obesity and metabolic syndrome and patent issued on allopurinol for treatment of hypertension; Royalties: Elsevier; Stock/stock options: Cardero. Dr. Sanchez-Lozada: Grant (money to institution): CONACyT. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Fructose on Body Weight in Controlled Feeding Trials John L. Sievenpiper , Russell J. de Souza , Arash Mirrahimi , Matthew E. Yu , Amanda J. Carleton , Joseph Beyene , Laura Chiavaroli , Marco Di Buono , Alexandra L. Jenkins , Lawrence A. Leiter , Thomas M.S. Wolever , Cyril W.C. Kendall , and David J.A. Jenkins Effects of Excessive Fructose Intake on Health John L. Sievenpiper , Russell J. de Souza , and David J.A. Jenkins Metrics Cited ByFructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistanceDirect renal effects of a fructose-enriched diet: interaction with high salt intakeMisconceptions about fructose-containing sugars and their role in the obesity epidemicCounteracting Roles of AMP Deaminase and AMP Kinase in the Development of Fatty Liver 19 June 2012Volume 156, Issue 12Page: 905KeywordsBody weightEatingFructosesGlucoseObesityOverweightRenal diseasesSucroseUric acidWeight gain ePublished: 19 June 2012 Issue Published: 19 June 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...