tbuckley/cabot-search huggingface dataset:
Idiopathic Pulmonary Fibrosis
Authors: WILLIAM T. POCHIS, ARTHUR Z. KRASNOW, B DAVID COLLIER, MARK W. MEWISSEN, URIAS A. ALMAGRO, ROBERT S. HELLMAN, ALI T. ISITMAN
Journal: Clinical Nuclear Medicine (1990)

A case of idiopathic pulmonary fibrosis with multiple areas of mismatch on ventilation-perfusion lung imaging in the absence of pulmonary embolism is presented. Idiopathic pulmonary fibrosis is one of the few nonembolic diseases producing a pulmonary ventilation-perfusion mismatch. In this condition, chest radiographs may not detect the full extent of disease, and xenon-133 ventilation imaging may be relatively insensitive to morbid changes in small airways. Thus, when examining patients with idiopathic pulmonary fibrosis, one should be aware that abnormal perfusion imaging patterns without matching ventilation abnormalities are not always due to embolism. In this setting, contrast pulmonary angiography is often needed for accurate differential diagnosis.
Esophageal Replacement with Reversed Gastric Tube
Authors: George B. Sanders
Journal: JAMA (1962)

Bleeding esophageal varices in children under 10 years of age usually require esophagogastric resection with interposition of a segment of colon. Disadvantages are the magnitude of the operation and the risk of later peptic ulceration in the implant. A 4-year-old child with severely bleeding varices underwent esophagogastric resection and replacement with a reversed gastric tube in 2 stages. Since the operation the child has not bled for 32 months and he eats normally. Advantages of the method are: (1) comparative ease of operation, which can be staged, if desired; (2) close resemblance anatomically and functionally of the "neoesophagus" to its normal counterpart; (3) one gastroesophageal anastomosis in the neck, rather than 3 bowel anastomoses, of which 2 are abdominal; and (41 absence of peptic ulceration. The operation should have great promise in resections for congenital and acquired esophageal lesions in infants and children.
TREATMENT OF FRACTURES IN THE REGION OF THE KNEE
Authors: G. R. Girdlestone
Journal: BMJ (1939)

Whenever a joint surface is fractured the main object of treatnient is the restoration of the form and plane of the articular surface.This is more difficult in the knee than in any other joint because only a small part of the opposed articular surfaces is in contact at any one period.At the same time the restoration of the true plane is rendered more important because the knee is a weight-bearing joint
CHEMOIMMUNOLOGICAL STUDIES ON THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS
Authors: Oswald T. Avery, Walther F. Goebel
Journal: The Journal of Experimental Medicine (1933)

The soluble specific substance of Pneumococcus Type I has been chemically isolated from the bacterial cells and from autolyzed cultures as an acetyl polysaccharide. So far as could be determined by the methods employed, the acetyl polysaccharide in highly purified form absorbs from Type I antipneumococcus serum all demonstrable type-specific precipitins, agglutinins and protective antibodies. Mice injected intraperitoneally with minute quantities of the acetyl polysaccharide develop active immunity to subsequent infection with Pneumococcus Type I. The immunity thus induced is type-specific. In several instances purpura has been observed in mice following the injection of larger amounts of the acetyl polysaccharide. Under the experimental conditions of this study, no type-specific precipitins, agglutinins or protective antibodies were demonstrable in the serum of rabbits following repeated intravenous injections of the Type I acetyl polysaccharide. The treated rabbits were not immune to subsequent infection with Pnemnococcus Type I. The acetyl polysaccharide is readily converted into its deacetylated derivative by treatment with dilute alkali. The chemical and immunological properties of the deacetylated polysaccharide are identical with those of the soluble specific substance in the chemical form in which it was originally isolated; the deacetylated form of the specific carbohydrate is non-antigenic, does not produce purpura in mice, and only incompletely absorbs the type-specific antibodies from Type I antipneumococcus serum. The immunological significance of the acetyl polysaccharide and its possible relationship to the specific substances isolated from Pneumococcus Type I by other workers are discussed.
William Kenneth Johnstone Walls
Authors: L M Adams
Journal: BMJ (2006)

Former senior lecturer in anatomy Leeds (b 1917; q Leeds 1940), died from pneumonia on 8 August 2005.

Kenneth Walls's early career, punctuated by five years' war service in the Royal Army Medical Corps, was that of an aspiring surgeon. Illness, however, precipitated a change of tack. He was appointed lecturer in anatomy at Leeds in 1949, becoming arguably the best loved teacher in the medical school as “Daddy” Walls. He was made a life fellow of the university in 1982. Predeceased by a son, he leaves a wife, Marguerite; a step-daughter; and a daughter.
Tryps and trips: cell trafficking across the 100-year-old blood–brain barrier
Authors: Marina Bentivoglio, Krister Kristensson
Journal: Trends in Neurosciences (2014)

One hundred years ago, Edwin E. Goldmann discovered the blood-brain barrier (BBB) using trypan dyes. These dyes were developed and named by Paul Ehrlich during his search for drugs to kill African trypanosomes (extracellular parasites that cause sleeping sickness) while sparing host cells. For Ehrlich, this was the first strategy based on the 'chemotherapy' concept he had introduced. The discovery of the BBB revealed, however, the difficulties in drug delivery to the brain. Mechanisms by which parasites enter, dwell, and exit the brain currently provide novel views on cell trafficking across the BBB. These mechanisms also highlight the role of pericytes and endocytosis regulation in BBB functioning and in disrupted BBB gating, which may be involved in the pathogenesis of neurodegeneration.
Biventricular versus right ventricular pacing decreases immune activation and augments nitric oxide production in patients with chronic heart failure
Authors: Andrzej Rubaj, Piotr Ruciński, Konrad Rejdak, Krzysztof Oleszczak, Dariusz Duma, Paweł Grieb, Andrzej Kutarski
Journal: European Journal of Heart Failure (2006)
Intrafamilial Clustering of<i>Helicobacter pylori</i>Infection
Authors: B Drumm, G I Perez-Perez, M J Blaser, P M Sherman
Journal: New England Journal of Medicine (1990)

Colonization of the gastric antrum by Helicobacter pylori (formerly Campylobacter pylori) has been associated with primary gastritis. We determined the frequency of colonization by H. pylori in gastric-antrum biopsy specimens from 93 children undergoing gastroscopy for the evaluation of upper gastrointestinal symptoms. We also determined H. pylori IgG antibody levels by enzyme-linked immunosorbent assay in coded serum samples from these children, family members, and control subjects of comparable ages.
The Changing Clinical Aspects of Infective Endocarditis: Descriptive Review of 90 Episodes in a French Teaching Hospital and Risk Factors for Death
Authors: S. Mouly, R. Ruimy, O. Launay, F. Arnoult, E. Brochet, J.-L. Trouillet, C. Leport, M. Wolff
Journal: Journal of Infection (2002)
Mantle cell lymphoma complicated by multiple widespread extranodal gastrointestinal lesions
Authors: Tomoya Iida, Suguru Nakagaki, Shuji Satoh, Haruo Shimizu, Hiroyuki Kaneto
Journal: Endoscopy (2015)

A 65-year-old man was hospitalized in our department with generalized lymphadenopathy. He was diagnosed with mantle cell lymphoma (MCL) complicated by peripheral tumorigenesis and marrow infiltration in a biopsy of cervical lymph nodes. Upper gastrointestinal endoscopy showed multiple tuberous lesions in the lower esophagus ([Fig. 1]) and the great curvature of the stomach ([Fig. 2 a]). These findings were diagnosed as multiple lymphomatous polyposis (MLP). Narrow-band imaging (NBI) with magnification showed microscopically dendritic abnormal vascular hyperplasia on tuberous parts of intragastric MLP lesions ([Fig. 2 b]). Lower gastrointestinal endoscopy showed a tuberous lesion in the cecum ([Fig.3 a]) and multiple small polypoid lesions throughout the large intestine ([Fig. 3 b]). Immunohistologic staining of biopsy tissues from the stomach ([Fig.4 a – d]) and large intestine ([Fig. 5 a – d]) gave positive results for CD5, CD20, and cyclin D1 colocalized with nuclear staining. These findings permitted a definite diagnosis of gastrointestinal lesions of MCL. Treatment is planned with R-hyper CVAD/MA followed by high dose chemotherapy combined with autologous peripheral blood stem cell transplantation.
The Cost of Instant Access to Health Care
Authors: Dorothy P. Rice
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early signs of vascular disease in homocystinuria: A noninvasive study by ultrasound methods in eight families with cystathionine-β-synthase deficiency
Authors: Paolo Rubba, Fulvio Faccenda, Paolo Pauciullo, Luciano Carbone, Mario Mancini, Pietro Strisciuglio, Romeo Carrozzo, Renata Sartorio, Ennio del Guidice, Generoso Andria
Journal: Metabolism (1990)
CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION
Authors: Michael Heidelberger, Elvin A. Kabat
Journal: The Journal of Experimental Medicine (1934)

1. A method, conforming to the criteria of quantitative analytical chemistry, is described for the estimation of the agglutinin content of antisera. Examples are given of the application of the method to various antipneumococcus sera. 2. This new, absolute method is discussed with regard to its relation to the commonly used relative methods.
HIV-1 Nef Interferes with Host Cell Motility by Deregulation of Cofilin
Authors: Bettina Stolp, Michal Reichman-Fried, Libin Abraham, Xiaoyu Pan, Simone I. Giese, Sebastian Hannemann, Polyxeni Goulimari, Erez Raz, Robert Grosse, Oliver T. Fackler
Journal: Cell Host & Microbe (2009)
Caffeine and Incident Hypertension in Women
Authors: Dae Hyun Kim
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurocutaneous melanosis: Clinical features of large congenital melanocytic nevi in patients with manifest central nervous system melanosis
Authors: Maria DeDavid, Seth J Orlow, Nathalie Provost, Ashfaq A Marghoob, Babar K Rao, Qasim Wasti, Carol L Huang, Alfred W Kopf, Robert S Bart
Journal: Journal of the American Academy of Dermatology (1996)

Background: Patients with a large congenital melanocytic nevus (LCMN) may have associated leptomeningeal melanocytosis with or without central nervous system (CNS) melanomas.These patients are considered to have neurocutaneous melanosis, a disorder that, when symptomatic or otherwise manifest neurologically, carries a poor prognosis even in the absence of malignancy.Objective: Our purpose was to identify typical clinical features in patients who have manifest CNS melanosis in association with LCMN.Methods: The records of 117 patients with LCMN in the New York University Registry of LCMN and the reports of 172 cases of LCMN in the world literature were included for features that might signal a high risk for the development of manifest CNS involvement.Results: Of the 289 patients with LCMN, 33 had manifest CNS melanosis.In all 33 in whom symptomatic neurocutaneous melanosis was diagnosed, the LCMNs were present in a posterior axial location on the head, neck; back, and/or buttocks."Satellite" nevi were known to be present in 31 of the 33 patients. Conclusion:Patients with LCMN in a posterior axial location, especially when associated with "satellite" melanocyfic nevi, are at greater risk for the development of manifest neurocutaneous melanosis than patients with LCMN limited to the extremities or those who are lacking satellite nevi.0
<scp>IL</scp>‐13‐producing <scp>BLT</scp>1‐positive <scp>CD</scp>8 cells are increased in asthma and are associated with airway obstruction
Authors: A. Dakhama, M. L. Collins, H. Ohnishi, E. Goleva, D. Y. M. Leung, R. Alam, E. R. Sutherland, R. J. Martin, E. W. Gelfand
Journal: Allergy (2013)

Abstract Background The role of CD 8 T lymphocytes in the pathogenesis of asthma is not well understood. We investigated whether a subset of IL ‐13‐producing BLT 1‐positive CD 8 T lymphocytes are present in asthmatic airways and are associated with impaired lung function. Methods Bronchoalveolar lavage ( BAL ) cells were obtained from asthmatic ( n = 39) and healthy control ( n = 28) subjects. Cells were stimulated with phorbol ester and ionomycin in the presence of brefeldin A and stained for CD 8, BLT 1, and intracellular IL ‐13. The frequency of IL ‐13‐producing BLT 1‐positive CD 8 T lymphocytes was compared between the two groups and related to lung function, serum I g E levels, and reticular basement membrane ( RBM ) thickness. Results A subset of CD 8 T lymphocytes expressing BLT 1 and producing IL ‐13 were detected in the airways of all asthmatic subjects. The frequency of this subset among recovered lymphocytes was significantly higher in the airways of asthmatic subjects compared with controls (mean ± SEM : 16.2 ± 1.4 vs 5.3 ± 0.5, respectively, P &lt; 0.001) and correlated positively with serum IgE levels and RBM thickness. More importantly, the frequency of CD 8 T lymphocytes co‐expressing BLT 1 and IL ‐13 was inversely related to FEV 1 and FEF [25–75] percent predicted values ( P &lt; 0.001). Conclusions A subset of CD 8 T lymphocytes expressing BLT 1 and producing IL ‐13 is present in the airways of asthmatics. The accumulation of these cells is associated with airway obstruction, suggesting that they may play a significant pathogenic role in bronchial asthma.
Amniotic band sequence in child of thalidomide victim
Authors: R Tenconi, M Clementi, L Notari, V R L. Vasco
Journal: BMJ (1994)

EDITOR,—Andrew P Read1 and Richard W Smithells2 dismiss W G McBride's hypothesis that thalidomide might be a mutagen.3 After this correspondence was published we saw a child with limb reduction defects born to a thalidomide victim.

The baby had the following isolated anomalies of the left hand: almost complete absence of the third and fourth fingers, with necrotic tissue attached to the tip, while the second finger had a deep constriction ring at the proximal phalanx with a hypertrophic distal segment and hypoplastic nail. Annular constriction was also present between the first and second phalanxes of the thumb and was associated with a fibrous remnant; the fifth finger was …
501 Lamivudine therapy in children with chronic hepatitis B
Authors: A. Liberek, A. Szaflarska-Poplawska, M. Korzon, G. Luczak, M. Gora-Gebka, E. Los Rycharska, W. Balko, G. Sikorska-Wisniewska, A. Szlagatys-Sidorkiewicz, M. Czerwionka-Szaflarska
Journal: Journal of Hepatology (2006)
An open letter to the chairman of the working party on part time postgraduate training.
Authors: S Roberts
Journal: BMJ (1984)

Britain has led the way in promoting part time training for women doctors.You are chairing a working party set up to examine the current scheme PM (79) 3 as it approaches its fifth birthday and to outline some recommendations for the future.The committee has met three times, but word is leaking out that it is depressed by its task, confused in its role, and about to miss the opportunity to continue to pioneer in this matter.To see the way forward means examining aims and specific successes and failures.Three groups have had aims in advancing part time training.The Department of Health and Social Security is interested in efficient use of medical manpower.Women have gradually moved from a wish to practise medicine in any capacity in the 1950s and early 1960s to the current demand for equal choice of career outcome with their full time colleagues, and the expectation of being able to combine this with a range of other activities, including parenting, already enjoyed by male colleagues.Anything less will be seen as unacceptable.The medical profession has mixed aims, poorly understood and articulated, but best expressed as a desire to solve the "woman doctor problem."The DHSS's aims are outlined in the circular PM (79) 3 and its predecessor HM (69) 6.12There is a need to make use of expensively trained doctors.Using this standard alone the schemes have been successful.At any one time 9100 of women
Controlled drinking for alcoholism.
Authors: J Merry
Journal: BMJ (1972)

the patient with clear-cut communicating hydrocephalus, the patient with epilepsy, the two patients intoxicated by drugs, the eight depressed patients, and the patient with mania.If we had wished to press the point we might have included 24 other patients in whom the results of investigation could have led to some attempt to treat the patients or their relatives; that is, treatment for the seven hypertensive patients with arteriosclerotic dementia, treatment for the six alcoholics, genetic counselling for the relatives of three patients with Huntington's chorea, symptomatic therapy for the five patients with malignant brain tumours, and even experimental antiviral treatment for the three patients with Creutzfeldt-Jacob's disease.-Weare, etc.,
THE RATIONALE FOR DIFFERENT CUT-OFF VALUES OF NON-COMPACTED TO COMPACTED RATIO IN THE DIAGNOSIS OF LEFT VENTRICULAR NON-COMPACTION
Authors: Karol Miszalski-Jamka, Agnieszka Bielka, Jan Glowacki, Jan Klys, Tomasz Miszalski, Radoslaw Kwiecinski, Mariola Szulik, Ewa Markowicz-Pawlus, Wojciech Mazur, Tomasz Kukulski, Zbigniew Kalarus
Journal: Journal of the American College of Cardiology (2012)
Cytosolic phospholipase A2α and peroxisome proliferator-activated receptor γ signaling pathway counteracts transforming growth factor β-mediated inhibition of primary and transformed hepatocyte growth
Authors: Chang Han, William C. Bowen, Guiying Li, Anthony J. Demetris, George K. Michalopoulos, Tong Wu
Journal: Hepatology (2010)

Hepatocellular carcinoma often develops in the setting of abnormal hepatocyte growth associated with chronic hepatitis and liver cirrhosis. Transforming growth factor β (TGF-β) is a multifunctional cytokine pivotal in the regulation of hepatic cell growth, differentiation, migration, extracellular matrix production, stem cell homeostasis, and hepatocarcinogenesis. However, the mechanisms by which TGF-β influences hepatic cell functions remain incompletely defined. We report herein that TGF-β regulates the growth of primary and transformed hepatocytes through concurrent activation of Smad and phosphorylation of cytosolic phospholipase A2α (cPLA2α), a rate-limiting key enzyme that releases arachidonic acid for the production of bioactive eicosanoids. The interplays between TGF-β and cPLA2α signaling pathways were examined in rat primary hepatocytes, human hepatocellular carcinoma cells, and hepatocytes isolated from newly developed cPLA2α transgenic mice. Conclusion: Our data show that cPLA2α activates peroxisome proliferator-activated receptor γ (PPAR-γ) and thus counteracts Smad2/3-mediated inhibition of cell growth. Therefore, regulation of TGF-β signaling by cPLA2α and PPAR-γ may represent an important mechanism for control of hepatic cell growth and hepatocarcinogenesis. (HEPATOLOGY 2010;)
Survival advantage from imatinib compared with the combination interferon-α plus cytarabine in chronic-phase chronic myelogenous leukemia: historical comparison between two phase 3 trials
Authors: Lydia Roy, Joëlle Guilhot, Tillmann Krahnke, Agnès Guerci-Bresler, Brian J. Druker, Richard A. Larson, Steve O'Brien, Charlene So, Giorgio Massimini, François Guilhot
Journal: Blood (2006)
Amyloidosis in Chronic Heroin Addicts with the Nephrotic Syndrome
Authors: JOHN SCHOLES
Journal: Annals of Internal Medicine (1979)

Four chronic heroin addicts had renal amyloidosis and the nephrotic syndrome. Amyloidosis had the secondary type of tissue distribution and developed after many years of addiction. That chronic immunologic stimulation by one or more exogenous antigens or multiple acute inflammatory episodes were important factors in the pathogenesis of amyloidosis in these patients is postulated. Amyloidosis, although uncommon, must be considered among the different types of renal involvement that are known to occur in drug addicts, especially those with the nephrotic syndrome, and amyloid should be specifically searched for in their renal biopsies.