tbuckley/cabot-search huggingface dataset:
Care and outcomes in young adults with type 1 diabetes: Services do not usually include psychological care
Authors: C. Bundy
Journal: BMJ (2003)

Editor—Services for younger people with diabetes nationally are poor1; many do not tailor services to working people in general, and most are ignorant of the specific lifestyles of younger people. People with diabetes are a great resource and could be enlisted to help shape services for others, but to achieve this a national strategy is needed for selection and training of suitable people to work with professionals to redesign services.

Active self management of diabetes is demanding physically and psychologically. The phrase “diabetes is not just for Christmas” comes to mind. For many years psychological support services for people with diabetes have been inadequate. There are too few psychologists or psychiatrists with knowledge of the demands of diabetes to make a difference.

The national service framework has gone some way to increasing the profile of psychological needs among people with diabetes, but without resources following nothing will change.2 Training specialist nurses to deliver first level psychological care may help but is no substitute for properly trained mental health practitioners who are also required and not just for extreme problems.

Unless there is specific investment in managing younger adults with diabetes and in particular investing in the psychological care provided by specialists, young people will continue to receive poor care and vote with their feet.
Hemodialysis for Isopropyl Alcohol Poisoning
Authors: LeRoy H. King
Journal: JAMA (1970)

To the Editor:—  A 70% solution of isopropyl alcohol (isopropanol), rubbing alcohol, is readily available as a potential source of poisoning; however, reported intoxications with this compound are not common.  A case of isopropyl alcohol intoxication was successfully treated by means of hemodialysis. So far as we know, the isopropyl alcohol blood level in this patient was higher than that in any case previously reported. This report should emphasize the life-saving potential of hemodialysis for severe isopropyl alcohol poisonings.  Report of a Case.—  A 28-year-old white man was admitted to the Indianapolis Veterans Administration Hospital at 8:00 PM on April 7, 1968. Forty-five minutes prior to admission, the patient was observed to have ingested approximately 1 liter of rubbing alcohol over a ten-minute period. Physical examination revealed a blood pressure of 60/40 mm Hg, a pulse rate of 70 beats per minute, and a rectal temperature of 97 F (36.1 C).
Incidence of Cancer among Men with the Felty Syndrome
Authors: Gloria Gridley
Journal: Annals of Internal Medicine (1994)

To estimate the incidence of cancer (especially lymphoproliferative malignancies) in patients with the Felty syndrome.A retrospective cohort study.A computerized database of all discharge records for 1969 to 1990 from a Veterans Affairs hospital.906 men with a discharge diagnosis of the Felty syndrome.Standardized incidence ratios (SIR) (ratios of observed-to-expected events) estimated the risk for specific cancers. Hospital records confirmed the diagnoses of the Felty syndrome and cancer.We observed a twofold increase in total cancer incidence (137 patients; SIR = 2.09; 95% CI, 1.8 to 2.5). The risk for non-Hodgkin lymphoma (19 patients; SIR = 12.8, CI, 7.7 to 20.0) was much greater than the twofold increase in risk for lymphoma generally reported for rheumatoid arthritis. The risk for leukemia was increased but only within 5 years of the first hospitalization for the Felty syndrome, (13 patients; SIR = 7.67; CI, 4.1 to 13.1).The increased risk for non-Hodgkin lymphoma after the Felty syndrome in our study is similar to the risk associated with the Sjögren syndrome and may reflect similar immunostimulatory mechanisms.
Right and left ventricular diastolic dysfunction in patients with myocardial infarction: a color M-mode analysis
Authors: C. Selton-Suty, P. Houplon, A. Grentzinger, J.-P. Proiss, L. Jacquemin, M. Angioï, Y. Juillière, N. Danchin, F. Cherrier
Journal: Journal of the American College of Cardiology (1998)
ENERGY METABOLISM OF THE FAILING HEART
Authors: George Decherd, Maurice B. Visscher
Journal: The Journal of Experimental Medicine (1934)

The failing heart is found to liberate energy in contraction to the same extent at any fiber length as the normal heart muscle, but it is unable to convert as much of the energy into useful work. Its efficiency as a machine is impaired. In the light of these observations the word "tonus" as applied to heart muscle becomes synonymous with "efficiency." The implications of these findings in applied cardiology are discussed.
Cough and Cold Remedies: a Potential Danger to Patients on Monoamine Oxidase Inhibitors
Authors: M. F. Cuthbert, M. P. Greenberg, S. W. Morley
Journal: BMJ (1969)

Experiments have been carried out in healthy volunteers to study the effects of phenylpropanolamine on the blood pressure and possible interactions with monamine oxidase inhibitors. In three subjects 50 mg. of phenylpropanolamine taken orally produced a modest rise of systolic pressure. Two proprietary preparations containing this dose in a slow-release form had no significant effect on the blood pressure. In all three subjects 100 mg. of phenylpropanolamine taken orally caused a more pronounced rise of systolic pressure and a rise of diastolic pressure. In contrast, 50 mg. of phenylpropanolamine orally caused a rapid and potentially dangerous rise of blood pressure in a subject taking the monamine oxidase inhibitor tranylcypromine, and a similar acute rise of blood pressure occurred in this subject when given a proprietary cough linctus containing the same dose of phenylpropanolamine. These and other results suggest that severe hypertensive episodes are more likely to occur when preparations containing phenylpropanolamine in a free form, rather than in slow-release form, are taken by patients being treated with monoamine oxidase inhibitors. The acute rise of blood pressure due to the interaction of phenylpropanolamine and monoamine oxidase inhibitors was reversed by intramuscular injection of phentolamine.
Osteopontin Is an Oncogenic Vav1– but not Wild-type Vav1–Responsive Gene: Implications for Fibroblast Transformation
Authors: Vered Schapira, Galit Lazer, Shulamit Katzav
Journal: Cancer Research (2006)

Mammalian wild-type Vav1 (wtVav1) encodes a specific GDP/GTP nucleotide exchange factor that is exclusively expressed in the hematopoietic system. Despite numerous studies, the mechanism underlying transformation of fibroblasts by oncogenic Vav1 (oncVav1) is not well defined. We identified osteopontin, a marker for tumor aggressiveness, as an oncVav1-inducible gene. Osteopontin is highly expressed in oncVav1-transformed NIH3T3 cells (NIH/oncVav1) but is barely detected in NIH3T3 expressing wtVav1 (NIH/wtVav1) even following epidermal growth factor stimulation, which normally induces osteopontin. Depleting oncVav1 in NIH/oncVav1 using small interfering RNA led to a considerable decrease in osteopontin, whereas reducing osteopontin expression did not affect oncVav1 expression, suggesting that oncVav1 operates upstream of osteopontin. Vav1-depleted NIH/oncVav1 cells, but not osteopontin-depleted NIH/oncVav1 cells, exhibited impaired extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase phosphorylation. Inhibition of ERK phosphorylation in NIH/oncVav1 cells led to a decrease in osteopontin expression, implying that the elevated osteopontin expression in these cells is dependent on ERK phosphorylation. Vav1-depleted or osteopontin-depleted NIH/oncVav1 cells lost their tumorigenic properties as judged by the soft agar and invasion assays, although loss of osteopontin expression had a less dramatic effect. Suppression of Vav1 expression in NIH/oncVav1 cells led to reversion to "normal" morphology, whereas when only osteopontin expression was diminished cells retained their transformed morphology. This work strongly supports a role for oncVav1 as a master oncogene and provides clues to the molecular mechanism underlying oncVav1 transformation.
INHIBITION OF INTERLEUKIN-1 ACTIVITY IS RELATED WITH REDUCED APOPTOSIS AND IMPROVED SPECKLE TRACKING MYOCARDIAL DEFORMATION IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: Ignatios Ikonomidis, Stavros Tzortzis, Ioannis Paraskevaidis, John Lekakis, Ioanna Andreadou, Maria Nikolaou, Pelagia Katsibri, Pinelopi Dasou, Dimitrios Th Kremastinos
Journal: Journal of the American College of Cardiology (2010)
Abstract 3916: Inhibition of GREB1 mRNA and protein limits ER+ breast tumor cell proliferation
Authors: H. James Hnatyszyn, Rebecca Olson, Rachel Pierce, Lynn Herbert, Marc E. Lippman
Journal: Cancer Research (2012)

Abstract Discovering the mechanism by which estrogen regulates breast cancer growth will aid in the identification of patients who will benefit from endocrine therapy. Estrogen (E2) binding to the estrogen receptor (ER) stimulates the proliferation of normal mammary cells and some breast cancers. Preventing ER expression or receptor-ligand interaction in hormone-responsive breast cancers inhibits cell division and promotes tumor cell death. However, the mechanism of E2-regulated breast cancer cell growth remains unclear. Although E2-regulated genes have been identified, those critically involved in growth regulation remain elusive. Identification of critical E2-regulated genes involved in mammary cell proliferation would elucidate the key pathway(s) supporting hormone-mediated tumor growth as well as provide insight into mechanisms of resistance to endocrine therapies and potential prognostic and therapeutic targets for ER+ breast cancer treatment. Gene regulated in breast cancer 1 (GREB1) is an estrogen-regulated gene that has been implicated in hormone-stimulated cell proliferation and is a candidate clinical marker for response to endocrine therapy. GREB1 mRNA and protein expression correlate with ER expression in breast tumors and the addition of estrogen to ER+ breast cancer cell lines leads to an increase in GREB1 expression and cell proliferation. The function of GREB1 and its role in ER+ breast tumors remains undefined. Experiments were designed to elucidate the role of GREB1 in ER+ breast cancer cell lines. ER+ breast cancer cell lines were transfected with GREB1-specific siRNA and control species. These tumor cell populations were evaluated for GREB1 mRNA and protein expression, cell growth and proliferation as well as invasion and migration in vitro. Sequence-specific siRNA effectively inhibited GREB1 mRNA and protein expression for more than 96 hours in MCF7 and T47D ER+ breast tumor cell lines. Utilizing the real-time Xcelligence system to monitor cell growth in culture suggested tumor cells treated with siRNA targeting GREB1 had significantly retarded cell proliferation. These observations suggest that GREB1 is a critical E2-regulated gene involved in breast tumor cell proliferation and is an exploitable target for novel breast cancer therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3916. doi:1538-7445.AM2012-3916
1043-48 Impact of cerebrovascular and peripheral arterial disease on outcomes after percutaneous coronary interventions
Authors: Eugenia Nikolsky, Roxana Mehran, George D Dangas, Gary S Mintz, Zoran Lasic, Tudor Vagaonescu, Ramona Pop, Alexandra J Lansky, Issam Moussa, Lynn Glasser, Sharif Ibrahim, Iyer Sriram, Martin B Leon
Journal: Journal of the American College of Cardiology (2004)
Love is not enough: Other-regarding preferences cannot explain payoff dominance in game theory
Authors: Andrew M. Colman
Journal: Behavioral and Brain Sciences (2007)

Even if game theory is broadened to encompass other-regarding preferences, it cannot adequately model all aspects of interactive decision making. Payoff dominance is an example of a phenomenon that can be adequately modeled only by departing radically from standard assumptions of decision theory and game theory – either the unit of agency or the nature of rationality.
New Model Raises Estimates of Child Tuberculosis in High-Burden Countries
Authors: M. J. Friedrich
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4872: Gynostemma pentaphyllum saponins alter the gut microflora composition and convert dysbiosis to eubiosis state in xenograft nude mice.
Authors: Lei Chen, William C.S. Tai, Frederick CC Leung, Manreet Singh, W.L. Wendy Hsiao
Journal: Cancer Research (2013)

Abstract Increasing evidence has shown that the gut microflora may have a crucial role in many diseases, including cancers. In our previous studies, we have demonstrated that treatment with total saponins of Gynostemma pentaphyllum (GpS) exerts anti-cancer effects in cellular and animal models. Our study showed that an unnatural shift in the microflora composition was observed in nude mice with xenografted tumors induced by GFP/Ras cells. To investigate the potential association between the anti-cancer effect of GpS and the gut microflora, we first investigated whether GpS treatment would affect the microflora composition. Enterobacterial Repetitive Intergenic Consensus sequence-based PCR (ERIC-PCR) was used to analyze the bacterial genomic DNA from the fecal samples of the experimental mice. ERIC-PCR analysis revealed that gut microbiota communities were able to restore back to the non-tumor state (day 0)) after treatment with GpS for 10 days. In addition, we found that GpS treatment can increase the levels of certain beneficial bacteria, including Bifidobacterium spp. and Lactobacillus spp. Furthermore, we defined the detailed changes in the gut microbiome by pyrosequencing of the 16S rRNA gene sequences. We found that Bacteroidetes/Firmicutes ratio showed an increased trend upon GpS treatment in xenograft nude mice. Furthermore, GpS altered certain species of bacteria, including the Clostridium cocleatum and Bacteroides acidifaciens, which have well-documented beneficial effects. In conclusion, this study has demonstrated GpS can potentially regulate and balance the gut microbial ecosystem by increasing symbionts. However, further investigation is required on whether this alteration of the gut microflora is the cause or consequence of the drug action. [This study was partially supported by FRG2/11-12/102 to WLWHsiao] Citation Format: Lei Chen, William C.S. Tai, Frederick CC Leung, Manreet Singh, W.L. Wendy Hsiao. Gynostemma pentaphyllum saponins alter the gut microflora composition and convert dysbiosis to eubiosis state in xenograft nude mice. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4872. doi:10.1158/1538-7445.AM2013-4872
Unexpected Finding of Cerebral Meningioma on 11C-PiB PET
Authors: Yuka Yamamoto, Yukito Maeda, Nobuyuki Kawai, Nobuyuki Kudomi, Yoshihiro Nishiyama
Journal: Clinical Nuclear Medicine (2013)

A 69-year-old man with no history of neurologic or psychiatric disorders underwent C-PiB PET as a healthy volunteer for amyloid imaging study. C-PiB PET images demonstrated an unexpected increased PiB binding in the left frontal region. MR images demonstrated an extra-axial left frontal mass lesion with mild enhancement, highly suggestive of meningioma. There is a limited amount of published information on the detection of meningioma with C-PiB PET.
CUB Domain–Containing Protein 1, a Prognostic Factor for Human Pancreatic Cancers, Promotes Cell Migration and Extracellular Matrix Degradation
Authors: Yuri Miyazawa, Takamasa Uekita, Nobuyoshi Hiraoka, Satoko Fujii, Tomoo Kosuge, Yae Kanai, Yoshihisa Nojima, Ryuichi Sakai
Journal: Cancer Research (2010)

CUB domain-containing protein 1 (CDCP1) is a membrane protein that is highly expressed in several solid cancers. We reported previously that CDCP1 regulates anoikis resistance as well as cancer cell migration and invasion, although the underlying mechanisms have not been elucidated. In this study, we found that expression of CDCP1 in pancreatic cancer tissue was significantly correlated with overall survival and that CDCP1 expression in pancreatic cancer cell lines was relatively high among solid tumor cell lines. Reduction of CDCP1 expression in these cells suppressed extracellular matrix (ECM) degradation by inhibiting matrix metalloproteinase-9 secretion. Using the Y734F mutant of CDCP1, which lacks the tyrosine phosphorylation site, we showed that CDCP1 regulates cell migration, invasion, and ECM degradation in a tyrosine phosphorylation-dependent manner and that these CDCP1-associated characteristics were inhibited by blocking the association of CDCP1 and protein kinase Cdelta (PKCdelta). CDCP1 modulates the enzymatic activity of PKCdelta through the tyrosine phosphorylation of PKCdelta by recruiting PKCdelta to Src family kinases. Cortactin, which was detected as a CDCP1-dependent binding partner of PKCdelta, played a significant role in migration and invasion but not in ECM degradation of pancreatic cells. These results suggest that CDCP1 expression might play a crucial role in poor outcome of pancreatic cancer through promotion of invasion and metastasis and that molecules blocking the expression, phosphorylation, or the PKCdelta-binding site of CDCP1 are potential therapeutic candidates.
Death from interventionist radiology: a cautionary tale.
Authors: C Dyer
Journal: BMJ (1986)

Dyer summarizes a 1986 legal inquiry in Scotland that has implications for physicians, particularly radiologists, practicing in Great Britain. A 7-year-old boy died within 24 hours of undergoing a neuroradiological procedure at a private hospital partly owned by the plastic surgeon who recommended the operation to the child's parents. The surgeon informed the parents neither of the risks involved nor of the fact that another physician, a neuroradiologist, would perform the embolization. During the inquiry, a neuroradiologist first consulted by the surgeon testified that the procedure entailed some risk of serious injury, and that she would have operated only in a better-equipped facility. The court ruled that both the surgeon and the radiologist were at fault, and that uncertainty over responsibility for the patient had resulted in the parents' not being informed fully of the procedure's risks, and in the child's not receiving proper post-operative monitoring.
Anti-nuclear RNP antibodies in two sisters
Authors: H. SHIIKI, S. MIYAGAWA, K. DOHI, H. YAMADA, M. HANATANI, H. ISHIKAWA
Journal: British Journal of Dermatology (1985)

Journal Article Anti‐nuclear RNP antibodies in two sisters Get access H. SHIIKI, H. SHIIKI First Department of Internal Medicine, Nara Medical University, Nara, Japan Search for other works by this author on: Oxford Academic Google Scholar S. MIYAGAWA, S. MIYAGAWA Department of Dermatology, Nara Medical University, Nara, Japan Sachiko Miyagawa, M.D., Department of Dermatology, Nara Medical University, Nara 634, Japan. Search for other works by this author on: Oxford Academic Google Scholar K. DOHI, K. DOHI First Department of Internal Medicine, Nara Medical University, Nara, Japan Search for other works by this author on: Oxford Academic Google Scholar H. YAMADA, H. YAMADA First Department of Internal Medicine, Nara Medical University, Nara, Japan Search for other works by this author on: Oxford Academic Google Scholar M. HANATANI, M. HANATANI First Department of Internal Medicine, Nara Medical University, Nara, Japan Search for other works by this author on: Oxford Academic Google Scholar H. ISHIKAWA H. ISHIKAWA First Department of Internal Medicine, Nara Medical University, Nara, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue 5, 1 November 1985, Pages 617–622, https://doi.org/10.1111/j.1365-2133.1985.tb02388.x Published: 01 November 1985 Article history Accepted: 23 April 1985 Published: 01 November 1985
Animals and Science Benefit From 'Replace, Reduce, Refine' Effort
Authors: Paul Cotton
Journal: JAMA (1993)

DEBATES over animal experiments are often emotional affairs pitting the sanctity of science against the image of beloved Fluffy in a laboratory hell. Attention tends to focus on the extremes—exposés of inhumane conditions on one end, mail bombs on the other. Even most substantive debate on the issue has been polarized, with activists intent on abolishing all animal research, and researchers and medical organizations steadfastly defending what they see as an invaluable and irreplaceable resource. Last month, however, several hundred animal protection activists, scientists, and regulatory agency officials from around the world were talking with instead of at each other. They gathered in Baltimore, Md, for the first World Congress on Alternatives and Animal Use in the Life Sciences, acknowledging that animal experimentation is not going to be abolished, at least not any time soon, but that it can and should be much improved so that far fewer animals are
Seeking 'Indian-acceptable' ways to fight hypertension
Authors: K. Glasbrenner
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal