The Prognostic Significance of Chromosome Abnormalities in Colon Tumors
Authors: HERBERT A. LUBS
Journal: Annals of Internal Medicine (1967)

Article1 August 1967The Prognostic Significance of Chromosome Abnormalities in Colon TumorsHERBERT A. LUBS, M.D., STUART KOTLER, M.D.HERBERT A. LUBS, M.D.Search for more papers by this author, STUART KOTLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-328 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe chromosome complements of all well-studied human solid tumors have been abnormal. Similar tumors have been shown to have widely different types of chromosome abnormalities. This variation suggests that many tumors could be subgrouped by the type of cytogenetic abnormality present as well as by the presence or absence of specific marker chromosomes. Until recently, the number of adequately studied tumors of a given type has been too small to permit possible correlation of these subgroups with various clinical parameters such as the tendency to metastasize, response to therapy, or longevity. Two studies have recently been reported in which a...References1. MARTINEAU M: A similar marker chromosome in testicular tumours. Lancet 1: 839, 1966. CrossrefMedlineGoogle Scholar2. SPIERSBAIKIE ASAG: Cytogenetic studies in the malignant lymphomas. Ibid., p. 506. Google Scholar3. ATKIN NB: The chromosomal changes in malignancy; an assessment of their possible prognostic significance. Brit. J. Radiol. 435: 213, 1964. CrossrefGoogle Scholar4. LUBSCLARK HAR: The chromosome complement of human solid tumors. I. Gastrointestinal tumors and technic. New Eng. J. Med. 268: 907, 1963. CrossrefMedlineGoogle Scholar5. KOTLERLUBS SHA: Comparison of direct and short term tissue culture technics in determining solid tumor karyotypes. Cancer Res. In press, October 1967. MedlineGoogle Scholar6. NEUTADASHILYTT RLKIG: Neoplastic tissue-culture cells. Lancet 1: 51, 1967. CrossrefMedlineGoogle Scholar7. HARDISTYSPEEDTILL RMDEM: Granulocytic leukaemia in childhood. Brit. J. Haemat. 10: 551, 1964. CrossrefMedlineGoogle Scholar8. LUBSSALMON HAJH: The chromosomal complement of human solid tumors. II. Karyotypes of glial tumors. J. Neurosurg. 22: 160, 1965. CrossrefMedlineGoogle Scholar9. LUBSFLANIGAN HAS: Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HERBERT A. LUBS, M.D.; STUART KOTLER, M.D.Affiliations: New Haven, ConnecticutFrom the Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.This study was supported in part by career development award K3-CA-19, 745, the National Cancer Institute, National Institutes of Health, Bethesda, Md., by research grant GM 11078-03, the General Medical Science Branch, U. S. Public Health Service, Washington, D. C., and by the John A. Hartford Foundation, Inc., New York, N. Y.Requests for reprints should be addressed to Herbert A. Lubs, M.D., Yale University School of Medicine, Department of Medicine, 333 Cedar St., New Haven, Conn. 06510. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFlow Cytometry in the Quantitation of DNA Aneuploidy and Cell Proliferation in Human DiseaseChromosomal banding patterns in human large bowel adenomasEvaluation of chromosomal diagnosis for hereditary adenomatosis of the colorectumInvolvement of chromosomes 7 and 12 in large bowel cancer: Trisomy 7 and 12q−Karyotypic findings in a colonic villous adenomaHuman large-bowel cancer: Correlation of clinical and histopathological features with banded chromosomesChromosomal banding patterns in human large bowel cancerGardner's syndromeChromosomes in solid tumorsChromosomenanomalien und TumorentstehungKaryology of a human colonic carcinoma (GW-39) serially xenografted in hamsters and in nude miceStem Cells, Nonproliferating Cells, and Their Kinetics in Normal and Neoplastic TissuesChromosomes and causation of human cancer and leukemia. XIV. Origin of a large number of markers in a cancerGenetics of Tumor CellsCytogenetische Untersuchungen an Praecancerosen und Carcinomen der Cervix uteriTissue cytogenetic studies in chronic ulcerative colitis and carcinoma of the colonChromosomal Changes in Human Tumors and LeukemiasTHE SPECIFICITY OF THE CHROMOSOMAL ABNORMALITIES IN HUMAN COLONIC POLYPS:Chromosome Changes in Human Malignant Tumors: An EvaluationChromosome constitution of transitional cell carcinoma of the urinary bladderReferencesChromosomes of precancerous lesions of the cervix uteri.New data and a reviewChromosomal characteristics of human pituitary adenomasRecent advances in molecular pathology: A review 1 August 1967Volume 67, Issue 2Page: 328-336KeywordsChromosomesColonCytogeneticsMedical servicesResearch grants ePublished: 1 December 2008 Issue Published: 1 August 1967 PDF downloadLoading ...