tbuckley/cabot-search huggingface dataset:
An Unusual Complication of Inferior Venacavography
Authors: P. RUBEN KOEHLER, HAROLD J. ISARD
Journal: Circulation (1962)

During inferior venacavography the tip of the catheter perforated the wall of the common iliac vein and entered the epidural space of the adjacent large lumbosacral trunk. Anatomically it is only at the level of the first sacral segment that the vein and nerve lie in very close proximity. Simultaneous opacification of the venous system and the epidural space resulted. A severe, temporary pain occurred upon the injection of the epidural space. There was no residual neurologic deficit.
Multiple Myeloma
Authors: Fred C. Collier, Alfred Reich, John W. King
Journal: New England Journal of Medicine (1951)

BENCE–JONES protein in the serum, sufficient to produce a visible precipitate at 56°C, is of rare occurrence. Review of the literature discloses no more than 20 such cases recorded since the initial report of this finding by Ellinger1 in 1899. Only 4 instances of serum precipitating at the 56°C. temperature utilized to inactivate the serum complement have been recorded in over 700,000 complement-fixation studies made in the serology laboratories of the Cleveland Clinic since its founding in 1921. During this time 162 cases of multiple myeloma have been observed in the Cleveland Clinic and the Cleveland Clinic Hospital.Apparently no . . .
Medallic Tributes to Sir William Osler and Their Historical Associations
Authors: Richard L. Golden
Journal: JAMA (1979)

The life of William Osier, MD, spanned three nations and two continents and left an enduring and universal impact on medicine. Osier held professorships during his career in Montreal, Philadelphia, Baltimore, and Oxford. His achievements great and small during these periods have been medallically commemorated both in his lifetime and posthumuously. The most famous of these portrayals is the Vernon plaque created in Paris at the turn of the century, of which many replicas and variants have been produced. The historical associations of these medallic tributes are relevant to better understanding of certain aspects of Osler's life and elucidating those unusual qualities of mind and character that made him unique. (<i>JAMA</i>242:2862-2867, 1979)
Musical expectancy: The influence of musical structure on emotional response
Authors: Carol L. Krumhansl, Kat R. Agres
Journal: Behavioral and Brain Sciences (2008)

Abstract When examining how emotions are evoked through music, the role of musical expectancy is often surprisingly under-credited. This mechanism, however, is most strongly tied to the actual structure of the music, and thus is important when considering how music elicits emotions. We briefly summarize Leonard Meyer's theoretical framework on musical expectancy and emotion and cite relevant research in the area.
Oxidative stress-related mechanisms are associated with xenobiotics exerting excess toxicity to Fanconi anemia cells.
Authors: Giovanni Pagano, Paola Manini, Debasis Bagchi
Journal: Environmental Health Perspectives (2003)

An extensive body of evidence has demonstrated the sensitivity of Fanconi anemia (FA) cells to redox-active xenobiotics, such as mitomycin C, diepoxybutane, cisplatin, and 8-methoxypsoralen plus ultraviolet irradiation, with toxicity mechanisms that are consistent with a deficiency of FA cells in coping with oxidative stress. A recent study has reported on excess sensitivity of FA complementation A group cells to chromium VI [Cr(VI)] toxicity, by postulating that a deficiency in Cr-DNA cross-link removal by FA cells and formation of Cr(VI)-associated cross-links may be the mechanism of Cr(VI)-induced cytotoxicity. However, the report failed to demonstrate any enhanced Cr uptake or, especially, any increase in Cr-DNA adducts. Thus, well-established findings on Cr(VI)-induced oxidative stress may explain excess sensitivity of FA cells to Cr(VI) in terms of its inability to cope with the Cr(VI)-induced prooxidant state.
Book: Errors, Medicine and the Law
Authors: N. W Goodman
Journal: BMJ (2002)

Alan Merry, Alexander McCall Smith Cambridge University Press, £17.95, pp 296 ISBN 0 521 00088 2 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> The present state of medicolegal matters offends for many reasons and at many levels. Not least it offends the ethical principle of distributive justice: it is a way for a few to take resources from the many. Australian judges may be becoming more “patient centred” ( BMJ 2002;324:39-41) and finding in favour of patients not told of small risks, but move much more in that direction and the United States beckons. There are large swathes of the US with no obstetricians because they … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
IL-13 and adenosine: partners in a molecular dance?
Authors: Gabriele Grünig
Journal: Journal of Clinical Investigation (2003)

Inflammation and airway remodeling are two responses readily apparent in asthma and other inflammatory disorders of the airway and lungs. Both adenosine and IL-13 play critical roles in contributing pathways. A new study reveals a previously unrecognized interaction between adenosine and IL-13 that indicates a mutual stimulation that may contribute to the nature and severity of airway inflammation and fibrosis.
Prevalence, Health Care Expenditures, and Orthopedic Surgery Workforce for Musculoskeletal Conditions
Authors: Robert H. Haralson
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patients With Polyps Larger Than 5 mm in Computed Tomography Colonoscopy Screening Have High Risk for Advanced Colonic Neoplasia in Asia
Authors: Joseph J.Y. Sung, Derek J.Y. Luo, Simon S.M. Ng, James Y.W. Lau, Kelvin K.F. Tsoi
Journal: Clinical Gastroenterology and Hepatology (2010)
Mutations in ACTN4, encoding α-actinin-4, cause familial focal segmental glomerulosclerosis
Authors: Joshua M. Kaplan, Sung H Kim, Kathryn N. North, Helmut Rennke, Lori A Correia, Hui-Qi Tong, Beverly J. Mathis, José-Carlos Rodríguez-Pérez, Philip G. Allen, Alan H. Beggs, Martin R. Pollak
Journal: Nature Genetics (2000)
Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury
Authors: Jochen Metzger, Torsten Kirsch, Eric Schiffer, Perihan Ulger, Ebru Mentes, Korbinian Brand, Eva M. Weissinger, Marion Haubitz, Harald Mischak, Stefan Herget-Rosenthal
Journal: Kidney International (2010)
Reduction in Ventricular Tachyarrhythmias With Statins in the Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II
Authors: Anant K. Vyas, Hongsheng Guo, Arthur J. Moss, Brian Olshansky, Scott A. McNitt, W. Jackson Hall, Wojciech Zareba, Jonathan S. Steinberg, Avi Fischer, Jeremy Ruskin, Mark L. Andrews
Journal: Journal of the American College of Cardiology (2006)
CD4+ CD25+ regulatory T cells are not functionally impaired in adult patients with IgE-mediated cow's milk allergy
Authors: Machteld M. Tiemessen, Els Van Hoffen, André C. Knulst, Joke-Afke Van der Zee, Edward F. Knol, Leonie S. Taams
Journal: Journal of Allergy and Clinical Immunology (2002)
20 Years After First Human Heart Transplant, 1987 May See 4000 Procedures Performed Worldwide
Authors: Kathryn Simmons Raithel
Journal: JAMA (1987)

THIS WEEK marks the 20th anniversary of the first human heart transplant (<i>JAMA</i>1967;202:23-24). Christiaan N. Barnard, MD, PhD, the surgeon who performed that transplant, recalled in a recent interview the events leading up to the historic operation. Cardiac transplantation to Barnard was merely a "new surgical technique." He began to think human heart transplants might be feasible when he read of a technique in 1959 in which the posterior walls of the recipient's atria were left behind. "Immediately, cardiac transplantation became a very straightforward surgical technique because it meant that you didn't have to anastomose the two vena cavae and the four pulmonary veins—all you had to anastomose were the two atria," he says. After studying for several months in the United States, Barnard, who is currently a scientist-in-residence at the Oklahoma Transplantation Institute, Baptist Medical Center, Oklahoma City, returned to South Africa ready to begin the patient-selection process.
New TB vaccine granted orphan drug status
Authors: T Lang, A V S Hill, H McShane, R Shah, A Towse, C Pritchard, M Garau
Journal: BMJ (2005)

Rationing in response to NHS deficits: rural patients are likely to be affected most See News, p 1426Editor-News that pressing financial problems have caused NHS trusts in Suffolk to set new "thresholds" to treatments such as joint replacements reinforces concerns raised by a recent BMA survey of medical directors of trusts in which over a third of respondents anticipated reductions of key services in response to funding shortfalls. 1 2 What has hitherto escaped comment is how cuts in services are far more likely to be felt in some parts of the country than others.Deficits in the NHS are invariably presented as a problem of financial mismanagement, but the pattern of deficits shows that the current resource allocation model discriminates against particular communities.According to the recently published accounts for 2004-5, 3 89 out of 303 (30%) English primary care trusts ended the year in deficit.The table shows how 301 of these trusts are distributed accorded to fifths of deprivation and rurality.Primary care trusts serving populations that are in both the most rural and the least deprived fifth were most likely to be in financial difficulties.Seventeen of the 25 (68%) in this category were in deficit.These trusts received the lowest funding allocation per head (£995).By contrast, only 3% (one of 34) of the primary care trusts serving populations that are in both the most urban and the most deprived fifths failed to break even in 2004-5.These trusts received the highest funding allocations per head (£1405).This shows that poor financial management can at best only partly explain why some trusts are in deficit.The pattern of deficits implies that NHS funding provides insufficient resources for rural areas, for comparatively affluent areas, and, most particularly, for areas that are both rural and affluent.The risk is that such measures will result in NHS services being subject to a new postcode lottery, in which rural residents are more likely to lose out.
Graduate Medical Education and Government Oversight-Reply
Authors: Marvin R. Dunn
Journal: JAMA (1997)

<h3>In Reply.</h3> —Dr Balaklaw is concerned that while most workforce planners concur that we either have trained or are on the verge of training too many physicians, this circumstance may not prevail in the future. We fully agree that future needs are too uncertain to predict precisely how many physicians of each discipline will be needed. That is the very reason that the 6 major professional organizations proposed in their consensus statement in January 1997<sup>1</sup>that a new public- and privatesector oversight advisory body should be formed to monitor closely the changing requirements and supply of physicians. The Congress chose to delegate this oversight review to the newly created Medicare Payment Advisory Commission (MedPAC). Only time will tell whether MedPAC will successfully monitor the changing needs and supply of physicians for responsible and timely adjustments, either up or down.
A Comparison Between Epidural Anaesthesia and Bed Rest in Sciatica
Authors: E. N. Coomes
Journal: BMJ (1961)

had not worked for the previous six months because of her supposedly sound financial position.She had been noisy at times, putting her bed out of the room, and soaking all the bed-linen in her possession with water.She said that everyone in the house, in the street, and in London, were trying to poison her to obtain her vast fortune.She was aurally hallucinated.She could hear the voices of the spirits which told her what to do.There was no memory defect or disorientation.Physical Findings.-Noabnormality found except a slight suggestion of slurring of speech.Blood and C.S.F.:W.R. positive
Inquiry calls for action to tackle north-south health divide
Authors: J. Wise
Journal: BMJ (2014)

An independent inquiry has called for action to tackle the widening health gap between the north and south of England. The report, commissioned by Public Health England, said that the prospect of greater devolution within England represented an opportunity to reduce health inequalities.

Due North: Report of the Inquiry on Health Equity for the North ,1 published by the Centre for Local Economic Strategies, said that a baby boy born in Manchester could expect to have 17 fewer years of good health …
Treatment of Mushroom Poisoning-Reply
Authors: John P. Hanrahan
Journal: JAMA (1984)

In Reply.—  The letter by Olson and colleagues aptly points out that some instances of mushroom poisoning are caused by mixed mushroom ingestion and that early symptoms caused by mushrooms of low toxicity could mask later, more serious manifestations caused by amatoxins. This possibility again emphasizes that mushrooms involved in poisonings must be promptly and accurately identified and that the patient's fluid, electrolyte, and acid-base status requires careful monitoring until recovery is complete.  We disagree that the use of thioctic acid and some other agents represents a grab bag approach to treatment of amatoxin poisoning and feel that their characterization of these therapies as antidotes is misleading. Our article stressed that intensive supportive care is the principal therapy for amatoxin poisoning and that the efficacy of thioctic acid has not been proved by controlled clinical trials. Nonetheless, numerous reports in the European and American literature, including an earlier report from
Use of Focus Groups to Explore Nutrition Practices and Health Beliefs of Urban Caribbean Latinos With Diabetes
Authors: Paula A Quatromoni, Marian Milbauer, Barbara M Posner, Nicolas Parkhurst Carballeira, Melanie Brunt, Stuart R Chipkin
Journal: Diabetes Care (1994)

OBJECTIVE Although Caribbean Latinos are two to three times more likely than non-Hispanic whites to develop diabetes, cultural influences on nutrition and health are poorly understood. To provide insight into important features of diabetes prevention and management, we conducted focus groups to explore nutrition practices and health beliefs. RESEARCH DESIGN AND METHODS Thirty low-income urban Caribbean Latinos with non-insulin-dependent diabetes mellitus (NIDDM) and four familymembers participated in four focus group interviews that were conducted in Boston and Cambridge, Massachusetts. Interviews were conducted in Spanish, were tape recorded, and were led and analyzed by Latino professionals from a community-based health organization. RESULTS Consistent themes described by participants were feelings of social isolation, little understanding of long-term consequences of diabetes, fatalism regarding the course of the disease, multiple barriers todiet and exercise interventions, skepticism regarding the value of preventive health behaviors, prevalent use of traditional nonmedicai remedies, and a clear need for culturally sensitive health-care providers and services. CONCLUSIONS The information from focus groups provides useful information for planning innovative intervention programs for chronic disease risk reduction that emphasize practical skills development, family/peer networks, empowerment techniques, and bilingual providers. We conclude that the focus group technique can be used effectively with low-income, urban minority populations to provide information on lifestyle behaviors and beliefs regarding chronic diseases that impact on health and nutritional status.
Leukapheresis for control of chronic myelogenous leukemia during pregnancy
Authors: Denis Fitzgerald, Jacob M. Rowe, Joanna Heal
Journal: American Journal of Hematology (1986)

Abstract Leukapheresis was used as the sole modality of treatment of a patient with chronic myelogenous leukemia (CML) during her pregnancy. The specific requirements for safe leukapheresis during pregnancy are discussed, and the literature describing the management of CML during pregnancy is reviewed. Leukapheresis may be the treatment of choice in selected pregnancy patients with CML since it avoids the potential teratogenic effects of chemotherapy or radiation therapy.
The Pharmacologic Approach to the Critically Ill Patient
Authors: Bart Chernow, D. Craig Brater
Journal: Annals of Internal Medicine (1988)

The use of lazaroids specifics of thrombolytic drug therapy monoclonal antibodies in the treatment of shock pharmacologic approaches to the eldely patient, the critically-ill patient, plus updates on treating paediatric patients pharmacology of muscle relaxation, such as during ventilation pharmacologic treatment of stroke cholinergic agents in treating conditions such as myasthenia gravis treatment of Parkinson's Disease and other muscle spasms immunosuppressive therapy in transplantation and other circumstances special considerations for bicarbonate therapy and resuscitation of hyponatremia use of surfacant in infant distress syndrome and adult respiratory distress syndrome.
Sensitization as a result of a religious rituat
Authors: A.J. Carmichael, I.S. Foulds
Journal: British Journal of Dermatology (1990)

Journal Article Sensitization as a result of a religious rituat Get access A.J. Carmichael, A.J. Carmichael The Skin Hospital, 35 George Road, Edgbaston, Birmingham B15 1PR, U.K. Search for other works by this author on: Oxford Academic Google Scholar I.S. Foulds I.S. Foulds The Skin Hospital, 35 George Road, Edgbaston, Birmingham B15 1PR, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue 6, 1 December 1990, Page 846, https://doi.org/10.1111/j.1365-2133.1990.tb04205.x Published: 01 December 1990
The Persistent Ostium Primum Atrial Septal Defect
Authors: S. GILBERT BLOUNT, OSCAR J. BALCHUM, GOFFREDO GENSINI
Journal: Circulation (1956)

Five patients with an ostium primum type of atrial septal defect were studied by clinical and laboratory methods and the diagnosis was verified either at the time of open-heart surgery and/or at autopsy. The atrioventricular valves formed the floor of the defect and were deformed in 4 of the 5 patients. Mitral insufficiency was present as a result of this valvular deformity in these four patients. This valvular deformity resulted in a high pitched blowing systolic murmur, audible over the apical and lower left sternal areas, and left axis deviation and indications of left ventricular hypertrophy, determined by electrocardiography. The deformity of the mitral valve is considered to be the basis for these variations from the typical findings found in the patient with an ostium secundum type of atrial septal defect and make the differential diagnosis of the persistent ostium primum possible under these circumstances.
291 TOLL-LIKE RECEPTOR 3, 7/8 AND 9 FUNCTION IS IMPAIRED IN HEPATITIS C PATIENTS WITH RAPID FIBROSIS POST LIVER TRANSPLANT
Authors: J. HowelP, R. Sawhney, N. Skinner, V. Markovska, A. Testro, P. Gow, P. Angus, K. Visvanathan
Journal: Journal of Hepatology (2011)
Long-term effects of lung cancer computed tomography screening on health-related quality of life: the NELSON trial
Authors: K.A.M. van den Bergh, M.L. Essink-Bot, G.J.J.M. Borsboom, E.T. Scholten, R.J. van Klaveren, H.J. de Koning
Journal: European Respiratory Journal (2010)

The long-term effects of lung cancer computed tomography (CT) screening on health-related quality of life (HRQoL) have not yet been investigated. In the Dutch–Belgian Randomised Lung Cancer Screening Trial (NELSON trial), 1,466 participants received questionnaires before randomisation (T0), 2 months after baseline screening (screen group only; T1) and at 2-yr follow-up (T2). HRQoL was measured as generic HRQoL (12-item short-form questionnaire and EuroQoL questionnaire), anxiety (Spielberger State-Trait Anxiety Inventory) and lung cancer-specific distress (impact of event scale (IES)). Repeated measures of ANOVA were used to analyse differences between the screen and control groups, and between indeterminate (requiring a follow-up CT) and negative screening result groups. At T0 and T2 there were no significant differences in HRQoL scores over time between the screen and control groups, or between the indeterminate or negative second-round screening result group. There was a temporary increase in IES scores after an indeterminate baseline result (T0: mean 4.0 (95% CI 2.8–5.3); T1: mean 7.8 (95% CI 6.5–9.0); T2: mean 4.5 (95% CI 3.3–5.8)). At 2-yr follow-up, the HRQoL of screened subjects was similar to that of control subjects, the unfavourable short-term effects of an indeterminate baseline screening result had resolved and an indeterminate result at the second screening round had no impact on HRQoL.
THE DIAGNOSTIC VALUE OF THE PLANTAR RESPONSE IN INSULIN COMA
Authors: P. M. D. Hart, H. P. Bond
Journal: BMJ (1929)

M,&y Is lcg Tig-t 'PL 895~~~~~~~*MUDALJoura gland produets (ovarian, thyroid, pituitary)'.The follow- ing case may be quoted in illustration of these conditions.A primipara, aged .28,since the birth of a child two years prev-iously, which was nursed for seven months, had never felt well.There was complete amenorrhpoea, and she complained of leucorrhoea.She gained nearly 3 st. in weight.The skin was dry, and the hair falling out.On examination she was found
Cobalamin C Mutation (Methylmalonic Aciduria and Homocystinuria) in Adolescence
Authors: Shlomo Shinnar, Harvey S. Singer
Journal: New England Journal of Medicine (1984)

DISORDERS of cobalamin (vitamin B12) can be divided into those associated with a deficiency of this essential cofactor and those due to inborn metabolic errors. When they are a result of an inborn error of metabolism, symptoms usually appear in infancy and consist of failure to thrive, developmental retardation, seizures, and hematologic abnormalities.1 2 3 4 5 6 7 8 9 10 In contrast, cobalamin-deficiency disorders generally occur in adulthood and are associated with megaloblastic anemia, subacute combined degeneration, and mental disturbances.11 In this report, we describe an adolescent girl with progressive dementia and myelopathy secondary to a familial intracellular defect of B]2 metabolism (cobalamin C mutation), . . .