tbuckley/cabot-search huggingface dataset:
Song of Stars
Authors: Martha Leslie
Journal: Annals of Internal Medicine (1997)

Ad Libitum1 April 1997Song of StarsMartha Leslie, MDMartha Leslie, MDStanford University Clinic, Palo Alto, CA 94304-2205Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-7-199704010-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Steadfast guardians of lonely menare the signpoststhat light the darknesssilent beacons harkenin the quietudein the vastness of the nightforever from tomorrowwith its joy or sorrow, thenBright or fragile heralds staya millenium before passing awaywhile ancient and future nationsinvest hope in the patternsto speak of events to beinspire exploration, creativityfrom Bethlehem to Orionstill returning at each day's endcreating room for dreams againFinal falling stars' flashand capture attentionlike men whose gifted time is briefintensity compensating durationfleeting though the moment besudden and unforewarnedbrilliantly burned in memoryas is all great beauty and painstars like men have their historytheir precious passing season Author, Article, and Disclosure InformationAffiliations: Stanford University Clinic, Palo Alto, CA 94304-2205Corresponding Author: Martha Leslie, MD, Stanford University Clinic, 900 Blake Wilbur Drive, Suite W2080, Palo Alto, CA 94304-2205. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1997Volume 126, Issue 7Page: 550KeywordsCreativityForecastingMemory Issue Published: 1 April 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ruptured Abdominal Aortic Aneurysm
Authors: D A Gervais, G J Whitman
Journal: New England Journal of Medicine (1996)

Figure 1. An 85-year-old man was brought to the emergency room after two hours of excruciating abdominal pain, nausea, and vomiting. He was hypotensive on admission. Physical examination revealed a pulsatile midabdominal mass. Emergency computed tomography revealed a ruptured abdominal aortic aneurysm (straight arrows). Surgical findings confirmed that the aneurysm had ruptured, with hemorrhage (curved arrows) into the right anterior pararenal space. Cardiac arrest occurred intraoperatively. The patient was resuscitated and taken to the surgical intensive care unit. On arrival, he had a second cardiac arrest and died despite vigorous resuscitative efforts.
A placebo- and active comparator-controlled dose escalation study of the pharmacokinetics, pharmacodynamics, and safety of inhaled large porous particle (AIRS) epinephrine in normal volunteers*1
Authors: J. Dunbar, A. Illeperuma, J. Milovanovic, J. Loewy, C. Osborn, P. Ahluwalia, J. Richards, E.W. Ehrich
Journal: Journal of Allergy and Clinical Immunology (2004)
Down-regulated IL-5 receptor expression on peripheral blood eosinophils from budesonide-treated children with asthma
Authors: C. Hellman, K. Lonnkvist, G. Hedlin, G. Hallden, J. Lundahl
Journal: Allergy (2002)

The expression and function of cytokine receptors on peripheral blood eosinophils (PBE) from healthy and asthmatic children are poorly characterized.The PBE count and expression of IL-5 receptor (R) and GM-CSFR positive PBE was analyzed in nonsteroid-treated asthmatic children (n = 13), budesonide-treated asthmatic children (n = 24) and healthy children (n = 16) by flow cytometry. Alterations in intracellular EG2-epitope expression were used to measure the in vitro responsiveness of PBE to recombinant IL-5 and GM-CSF.The PBE count was increased (P < 0.05) in both asthmatic groups, independent of treatment, as compared to healthy children. The IL-5R expression on PBE, as well as the in vitro responsiveness of PBE to recombinant IL-5, was reduced (P < 0.05), in budesonide-treated asthmatic children compared to nonsteroid-treated asthmatic children and healthy children. The proportion of GM-CSFR positive PBE and in vitro responsiveness of PBE to recombinant GM-CSF were not different between the groups. In vitro treatment with budesonide did not down-regulate the proportion of IL-5R positive PBE.Budesonide-treatment of asthmatic children induces a selectively reduced IL-5R expression on PBE, concomitant with a reduced in vitro responsiveness of PBE to IL-5. We suggest that this budesonide-related down-regulation of the IL-5R might be a mechanism by which steroid treatment inhibits the action of IL-5 on eosinophil accumulation and activation in vivo.
Digoxin dosage in infants.
Authors: D Pickering
Journal: BMJ (1979)

DiscussionRadiosynoviorthosis aims at satisfactory irradiation of the synovium with minimal irradiation of other tissues.Of the yttrium radiocolloids, the silicate is best retained in the knee8 and is associated with least chromosomal damage.4Further attempts to reduce extra-articular leakage have included using longer periods of bed rest and encasing the limb in plaster-of- Paris after injection, which considerably increase the nursing work load and the patient's discomfort.This study has shown that a firm, light splint on a mobilised patient minimises extra-articular spread.The chromosomal damage observed in mobilised patients is comparable with that found in other studies of fully immobilised patients.4 5
Achalasia of the Esophagus Complicated by Varices and Massive Hemorrhage
Authors: Avram R. Kraft, Howard A. Frank, Donald J. Glotzer
Journal: New England Journal of Medicine (1973)

MASSIVE and life-threatening hemorrhage from the esophagus was encountered in two patients with achalasia. Since bleeding of major clinical proportions has rarely been mentioned as a complication of this disease, the case reports are presented together with a discusson of management and a hypothesis for the cause of the esophageal varices found in both cases.Case ReportsCase 1. A 59-year-old man was hospitalized in July, 1965, because of profuse regurgitation of blood. A diagnosis of achalasia of the esophagus had been made 30 years previously by x-ray examination. Aside from a series of dilatations with Hurst bougies in 1938, . . .
Hurricane Uma: a wild monster.
Authors: F Emrys-Roberts
Journal: BMJ (1987)

When I chose Vanuatu for my elective I imagined two months of paradise on these south Pacific islands.No one warned me that it was the cyclone season, and nothing could have prepared me for the immense and destructive power of Hurricane Uma.After my first six weeks in Port Vila, the capital, I flew south 160 km (100 miles) to the island of Tanna, one of the most primitive in the country.Here "custom" villages still exist, defiant ofWestern influences.The women wear grass skirts and the men loin cloths or in through the broken hurricane window like a fire hose on full force.The noise was indescribable and the whole scene quite petrifying, heightened by the continuous flashes of lightning illuminating the chaos outside.
Required Health and Family Life Education in the Schools
Authors: William W. Herman
Journal: JAMA (1966)

It is on this Old Testament basis that this communication is being written to bring to the medical profession a subject which is fundamental in our dealings with human beings. This is perhaps the first published report detailing a procedure in which a local medical society has taken a lead in the community to institute a preventive education program. In 1963 a committee was appointed by the Academy of Medicine of Cleveland to investigate the necessity of teaching health and family life in the schools of greater Cleveland. The committee was formed primarily because we are seeing in our practice of pediatrics an increased number of cases of emotional problems manifested by psychosomatic complaints, in contrast to our experience of observing organic illnesses. We are seeing children who complain of abdominal pain, headaches, enuresis, or encopresis; children who become obese; children who develop school phobias or become underachievers even though
Racial Differences in the Incidence of Treatment for End-Stage Renal Disease
Authors: Stephen G. Rostand, Katharine A. Kirk, Edwin A. Rutsky, Brenda A. Pate
Journal: New England Journal of Medicine (1982)

THE number of patients undergoing treatment for end-stage renal disease (ESRD) has increased dramatically since 1973, when Medicare began funding its treatment. Federal support has made dialysis and transplantation available to all patients, including the economically disadvantaged, who previously had difficulty obtaining financial support for these expensive types of treatment. Since then, the number of patients entering ESRD programs has greatly exceeded the original estimates formulated in 19671 and is now much greater than the number of patients undergoing treatment for ESRD in the most economically and technologically advanced countries of Europe.2 The reasons for this are uncertain. Relman and . . .
Intraoperative Ketoacidosis and Malnutrition
Authors: Alexander Sorisky
Journal: Annals of Internal Medicine (1988)

Brief Reports15 August 1988Intraoperative Ketoacidosis and MalnutritionAlexander Sorisky, MD, John T. Devlin, MDAlexander Sorisky, MDSearch for more papers by this author, John T. Devlin, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-4-337 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStarvation is one cause of increased anion-gap metabolic acidosis; elevated levels of beta-hydroxybutyrate and acetoacetate can cause ketoacidosis. During starvation ketosis, the usual beta-hydroxybutyrate: acetoacetate ratio is 4:1, which reflects the mitochondrial redox potential. Clinically significant ketoacidosis due to starvation takes 1 to 2 weeks to develop (1). We report a case of acute intraoperative ketoacidosis in a non-diabetic patient.A 47-year-old woman with a history of intermittent menorrhagia was diagnosed as having endometrial carcinoma 1 month before hospitalization for a radical hysterectomy. On learning of the diagnosis, she started a restricted-calorie macrobiotic diet. During the month before surgery, she...References1. Cahill G. Ketosis. Kidney Int. 1981;20:416-25. CrossrefMedlineGoogle Scholar2. Bergmeyer H, ed. Methods of Enzymatic Analysis. New York: Academic Press; 1974. Google Scholar3. . Perioperative parenteral nutrition. Ann Intern Med. 1987;107:252-3. LinkGoogle Scholar4. RizzaHaymondMilesVerdonkCryerGerich RMJCPJ. Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man. Am J Physiol. 1980;238:E467-72. MedlineGoogle Scholar5. Miller R, ed. Anesthesia. New York: Churchill Livingstone; 1986. Google Scholar6. BjorkmanEriksson OL. Influence of a 60-hour fast on insulin-mediated splanchnic and peripheral glucose metabolism in humans. J Clin Invest. 1985;76:87-92. CrossrefMedlineGoogle Scholar7. CarawayWatts WN. Carbohydrates. In: Tietz NW, ed. Textbook of Clinical Chemistry. Philadelphia: W.B. Saunders; 1986:808. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Alexander Sorisky, MD; John T. Devlin, MDAffiliations: From the University of Vermont, Burlington, Vermont. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1988Volume 109, Issue 4Page: 337-338KeywordsAcidosisDietHospitalizationsHysterectomyMalnutritionStarvationSurgery ePublished: 1 December 2008 Issue Published: 15 August 1988 PDF downloadLoading ...
Successful Open Cardiac Massage After 75 Minutes of Closed Massage
Authors: Everett Shocket
Journal: JAMA (1967)

THIS EXPERIENCE is recorded to refute the belief that 30 to 40 minutes of closed-chest massage is an adequate trial.<sup>1,2</sup>It also refutes the belief that fixed dilated pupils and loss of spontaneous respirations are evidence of irreversible brain damage. <h3>Report of a Case</h3> A 32-year-old white man was treated for ulcerative colitis for 11 years with steroids, sulfonamides, and anticholinergics. Because of multiple, draining perianal fistulae, recurrent rectal hemorrhages, and progressively debilitating fever, a total colectomy was advised. Prior to surgery, the heart, the lungs, and even the abdomen were unremarkable upon examination. A preoperative anemia was corrected by the transfusing of 7 pt of whole blood in six days. An abdominoperineal total colectomy with ileostomy required six hours and 8 pt of blood, but was otherwise uneventful. Four hours after surgery, brisk perineal bleeding dropped the blood pressure to 80/65 mm Hg before a perineal bleeder was
The Practice of Disease Prevention
Authors: Ernest L. Wynder
Journal: JAMA (1974)

MODERN medicine has successfully learned how to prevent the most devastating of the infectious diseases. These advances were the result of the coordinated efforts of research workers and practicing physicians, as well as the willingness of the public to accept preventive measures. With this record, an obvious question is why similar results have not been achieved for today's major causes of death, particularly cardiovascular diseases, stroke, and cancer, which together account for some 70% of all deaths in the United States. Much time has passed since statistically proven risk factors for heart attacks were established by the Framingham Study, since it was demonstrated that treatment of hypertension leads to a reduction in the occurrence of strokes, since cigarette smoking was shown to be related to lung cancer and a variety of other diseases, and since Papanicolaou first demonstrated the value of cervical smears in identifying early lesions of the cervix.
1142-177 Antecedent hypertension and the risk of subsequent left ventricular remodelling after acute myocardial infarction: Insights from the survival and ventricular enlargement trial
Authors: Satish Kenchaiah, Marc A Pfeffer, Martin St. John Sutton, Ted Plappert, Jean-Lucien Rouleau, Gervasio A Lamas, Zion Sasson, John O Parker, Edward M Geltman, Eugene Braunwald, Scott D Solomon
Journal: Journal of the American College of Cardiology (2004)
Homogeneous PLGA-lipid nanoparticle as a promising oral vaccine delivery system for ovalbumin
Authors: Tongtong Ma, Lianyan Wang, Tingyuan Yang, Guanghui Ma, Siling Wang
Journal: Asian Journal of Pharmaceutical Sciences (2014)

In this study, a polymeric lipid nanoparticle (NP) (simplified as Lipid NP) was reported as a promising oral vaccine delivery system. The Lipid NPs composed of a hydrophobic polymeric poly(d,l-lactide-co-glycolide) (PLGA) core and a surface coating of lipid monolayer. Membrane emulsification technique was used to obtain uniform-sized Lipid NPs. Ovalbumin (OVA) was used as a model vaccine. Compared with the pure PLGA NPs, the Lipid NPs achieved higher loading capacity (LC) and entrapment efficiency (EE) for the encapsulated OVA. An in vitro oral release profile showed that the OVA-Lipid NPs were with lower initial burst and could protect the loaded OVA from the harsh gastrointestinal (GI) environment for a long time. In addition, a human microfold cell (M-cell) transcytotic assay demonstrated that due to a lipid layer structure on the particle surface, the Lipid NPs showed higher affinity to the M-cells. Since the M-cell in the intestinal epithelium played an important role in particle transportation as well as intimately associated with the underlying immune cells, the OVA-Lipid NPs effectively induced mucosal and humoral immune responses.
Abstract 3132: Beta-catenin regulates c-Myc and CDKN1A expression in breast cancer cells.
Authors: Jinhua Xu, Yinghua Chen, Andrey Khramtsov, Dezheng Huo, Kathleen Goss, Olufunmilayo I. Olopade
Journal: Cancer Research (2013)

Abstract Basal-like breast cancer (BLBC) is associated with a poor prognosis and lacks therapeutic targets. The molecular pathways leading to the development of basal-like tumors are not well understood. We reported recently that nuclear and cytosolic accumulation of beta-catenin was enriched in BLBC, suggesting Wnt pathway activation in this specific subtype. c-Myc has been placed as a downstream effector of Wnt/beta-catenin pathway in colorectal cancer. However, exactly how the Wnt pathway regulates c-Myc in breast cancer and the biological significance of this regulation are poorly understood. In this study, we found that c-Myc is highly expressed in the basal-like subtype in comparison to the other four breast cancer subtypes by IHC staining. In addition, we confirmed the concordant expression of beta-catenin and c-Myc in basal-like breast tumors. Both c-Myc and beta-catenin proteins are highly expressed in the basal-like cell lines in comparison with non-basal-like cell lines. After silencing beta-catenin using siRNA, c-Myc expression was decreased in none-BLBC cells. In contrast, c-Myc mRNA and protein expression was up-regulated in the BLBC cell lines, suggesting that beta-catenin regulates c-Myc expression in a cell type dependent manner in breast cancer. Although we did not detect any TCF promoter activity in all breast cancer cell lines, decreased c-Myc promoter activity was observed after inhibiting beta-catenin by siRNA in non-BLBC cells; however, inhibition of beta-catenin or over-expression of dominant-negative LEF had no effect on c-Myc promoter activity in BLBC cell lines. In contrast, CDKN1A mRNA and p21 protein expression were significantly increased in all breast cancer cell lines upon beta-catenin silencing. Interestingly, inhibiting beta-catenin expression alone does not induce apoptosis in breast cancer cell lines despite c-Myc regulation,, but we observed a modest increase of cells in G1 and decrease of cells in S phase in the cell lines with beta-catenin silencing. Collectively, these findings suggest that the regulation of c-Myc in breast cancer cells is dependent on the molecular subtype, and that beta-catenin-mediated control of c-Myc and p21 may control the balance of cell death and proliferation in breast cancer by both TCF-dependent and TCF-independent mechanisms. Citation Format: Jinhua Xu, Yinghua Chen, Andrey Khramtsov, Dezheng Huo, Kathleen Goss, Olufunmilayo I. Olopade. Beta-catenin regulates c-Myc and CDKN1A expression in breast cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3132. doi:10.1158/1538-7445.AM2013-3132
Off-Label Use of<i>Haemophilus</i>Vaccine in Combination With DTaP Vaccine
Authors: Stuart L. Nightingale
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discerning the Incidence of Symptomatic and Asymptomatic Episodes of Atrial Fibrillation Before and After Catheter Ablation (DISCERN AF)
Authors: Atul Verma, Jean Champagne, John Sapp, Vidal Essebag, Paul Novak, Allan Skanes, Carlos A. Morillo, Yaariv Khaykin, David Birnie
Journal: JAMA Internal Medicine (2012)

The DISCERN AF study (Discerning Symptomatic and Asymptomatic Episodes Pre and Post Radiofrequency Ablation of Atrial Fibrillation) monitored atrial fibrillation (AF) using an implantable cardiac monitor (ICM) to assess the incidence and predictors of asymptomatic AF before and after catheter ablation.Patients with symptomatic AF underwent implantation of an ICM with an automated AF detection algorithm 3 months before and 18 months after ablation. Patients kept a standardized diary to record symptoms of arrhythmia, and ICM data were downloaded every 3 months. All episodes were blindly adjudicated and correlated with the diary. Asymptomatic recurrences were ICM episodes of 2 minutes or longer with no associated diary symptoms.Fifty patients had 2355 ICM episodes. Of these, 69.0% were true AF/atrial flutter (AFL)/atrial tachycardia (AT); 16.0%, sinus with extrasystoles; 11.0%, artifact; and 4.0%, sinus arrhythmia. Total AF/AFL/AT burden was reduced by 86% from a mean (SD) of 2.0 (0.5) h/d per patient before to 0.3 (0.2) h/d per patient after ablation (P < .001), and 56.0% of all episodes were asymptomatic. The ratio of asymptomatic to symptomatic AF episodes increased after ablation from 1.1 to 3.7 (P = .002). By symptoms alone, 29 of 50 patients (58%) were free of AF/AFL/AT after ablation compared with 23 of 50 (46%) using ICM-detected AF/AFL/AT recurrence. Asymptomatic episodes were more likely AFL/AT and were significantly shorter and slower, with lower heart rate variability. However, the postablation state was the strongest independent predictor of asymptomatic AF.The ratio of asymptomatic to symptomatic AF episodes increased from 1.1 before to 3.7 after ablation. Postablation state is the strongest predictor of asymptomatic AF. Symptoms alone underestimate postablation AF burden, with 12% of patients having asymptomatic recurrences only.clinicaltrials.gov Identifier: NCT00745706.
Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphatase
Authors: Erwin Daniel Brenndörfer, Juliane Karthe, Lars Frelin, Patricia Cebula, Andreas Erhardt, Jan Schulte Esch, Hartmut Hengel, Ralf Bartenschlager, Matti Sällberg, Dieter Häussinger, Johannes Georg Bode
Journal: Hepatology (2009)

The hepatitis C virus (HCV) is a worldwide major cause of chronic liver disease with a high tendency to establish a persistent infection. To permit persistent replication of viral genomes through the cellular translation machinery without affecting host cell viability, viruses must have developed mechanisms to control cellular cascades required for sufficient viral replication, on the one hand, and to adapt viral replication to the cellular requirements on the other hand. The present study aimed to further elucidate mechanisms by which HCV targets growth factor signaling of the host cell and their implications for viral replication. The study describes a novel mechanism by which HCV influences the activation of the epithelial growth factor receptor/Akt pathway through a nonstructural (NS)3/4A-dependent down-regulation of the ubiquitously expressed tyrosine phosphatase T cell protein tyrosine phosphatase (TC-PTP). NS3/4A is demonstrated to cleave TC-PTP protease-dependently in vitro at two cleavage sites. The in vivo relevance of this finding is supported by the fact that down-regulation of TC-PTP protein expression could also be demonstrated in HCV-infected individuals and in transgenic mice with intrahepatic expression of NS3/4A. Conclusion: This down-regulation of TC-PTP results in an enhancement of epithelial growth factor (EGF)-induced signal transduction and increases basal activity of Akt, which is demonstrated to be essential for the maintenance of sufficient viral replication. Hence, therapeutic targeting of NS3/4A may not only disturb viral replication by blocking the processing of the viral polyprotein but also exerts unforeseen indirect antiviral effects, further diminishing viral replication. (HEPATOLOGY 2009;49:1810–1820.)