tbuckley/cabot-search huggingface dataset:
Red Blood Cell Labeling with Technetium-99m Effect of Radiopaque Contrast Agents
Authors: JoELLEN FINKEL, L RAO CHERVU, ROBERT G. BERNSTEIN, SURESH C. SRIVASTAVA
Journal: Clinical Nuclear Medicine (1988)

Radiographic contrast agents have been reported in the literature to interfere significantly with red blood cell (RBC) labeling in vivo by Tc-99m. Moreover, in the presence of contrast agents, red cells have been known to undergo significant morphologic changes. These observations led to the current RBC labeling study in patients (N &equals; 25) undergoing procedures with the administration of contrast media. Before and after contrast administration, blood samples were drawn from each patient into vacutainer tubes containing heparin and RBC labeling was performed using 1-ml aliquots of these samples following the Brookhaven National Laboratory protocol. The differences in average percentage labeling yield with and without contrast media were not significant. In vivo labeling in hypertensive rats with administration of contrast media up to 600 mg likewise consistently gave high labeling yields at all concentrations. Purported alterations in cell labeling attributed to contrast agents are not reflected in these studies, and other pathophysiologic factors need to be identified to substantiate the previous reports. In vitro study offers a potentially useful and simple method to delineate effects of various agents on cell labeling.
The crystal structure of IgE Fc reveals an asymmetrically bent conformation
Authors: Tommy Wan, Rebecca L. Beavil, Stella M. Fabiane, Andrew J. Beavil, Maninder K. Sohi, Maura Keown, Robert J. Young, Alistair J. Henry, Ray J. Owens, Hannah J. Gould, Brian J. Sutton
Journal: Nature Immunology (2002)
THE RÔLE OF PHYSICAL THERAPY IN THE TREATMENT OF PRECANCEROUS AND CANCEROUS DERMATOSES
Authors: JOSEPH JORDAN ELLER
Journal: JAMA (1933)

Physical agents in one form or another, singly or combined, play practically the entire rôle in the treatment of precancerous and cancerous skin lesions. The dermatologist is quite fortunate in the vast array of physical agents at his disposal. One may choose from the following according to the type and size of the various lesions: Radium. Roentgen rays. Grenz rays. High frequency: Cutting current. Electrodesiccation. Electrocoagulation. Electrocautery. Actual cautery. Electrolysis. Carbon dioxide snow. Curet. Scalpel. The well trained therapist is not a faddist. He should individualize in every case and be prepared to use the ideal physical agent or combination of physical agents for the case in question. By means of different physical methods or their combinations, one may arrive at the same result. This is only a matter of personal experience and technic. A list of the various lesions treated by physical agents is given in the
Long-Term Hemodialysis: The Management of the Patient With Chronic Renal Failure
Authors: Milton E. Rubini
Journal: JAMA (1968)

The 50,000 individuals who die each year in the United States of uremia have brought chronic dialysis to the mandatory attention and concern of the medical profession. Because such therapy offers substantial salvage of useful and reasonably comfortable life of patients otherwise dying of terminal renal disease, it has become a social as well as a medical issue, as the facilities available can handle only a minute fraction of those who might benefit from therapy. This book attempts to review the current state of chronic dialysis, bringing together the extensive experience and opinion of a group of pioneer "dialyzers" from the Boston, New York, and Seattle centers. The introductory chapter is written by Dr. John Merrill whose own book, some 18 years ago, stimulated substantially the introduction of the artificial kidney into clinical medicine. He traces the metamorphosis of dialysis from an acute therapy used to supplant temporary renal failure
Blood Transfusion Before Radiation for Malignancies
Authors: Thomas K. Hunt
Journal: JAMA (1989)

<h3>To the Editor.—</h3> One of your questioners, Dr Mullins<sup>1</sup>of Corpus Christi, Tex, asked about the rationality of giving blood transfusions in expectation of enhancing the effectiveness of radiation therapy for malignancy in anemic patients. Your consultant, Dr Glatstein, felt that the practice was orthodox and rational because radiation therapy is more effective in well-oxygenated cells and because hemoglobin is likely to increase the oxygenation of tumor cells. I feel that Dr Mullins asked an important question, and would like to differ somewhat from the answers given in your column. First, I do not dispute the evidence that links susceptibility to ionizing radiation with increased tumor/ tissue PO<sub>2</sub>. However, I do contest the assumption that increased hemoglobin concentrations achieve increased tissue/tumor PO<sub>2</sub>. The role of hemoglobin is, in fact, to support PO<sub>2</sub>in tissues that rapidly consume oxygen, the best example of which is working muscle.
Extracorporeal Shock Wave Lithotripsy in the Treatment of Proximal Ureteral Stones: Does the Presence and Degree of Hydronephrosis Affect Success?
Authors: Christian Seitz, Harun Fajkovic, Matthias Waldert, Enis Tanovic, Mesut Remzi, Gero Kramer, Michael Marberger
Journal: European Urology (2005)
Antibody-Induced Red-Cell Aplasia
Authors: David G. Nathan
Journal: New England Journal of Medicine (1981)

Measurement of erythrokinetics with radioisotopes and the use of in vitro cultures of marrow cells in various semisolid media have enhanced our understanding of the regulation of erythropoiesis. In the 1950s and 1960s, Alpen, Lajtha, and Stohlmann and their co-workers1 2 3 showed that marrow proerythroblasts are partially renewed from a pool of mature progenitor cells. Later, Axelrad et al. demonstrated that this pool (called erythroid colony-forming units or CFU-Es), makes up about 0.5 per cent of the nucleated marrow cells.4 They also discovered a more primitive committed erythroid progenitor, the erythroid burst-forming unit (or BFU-E), present as approximately 0.05 per cent . . .
Sputum and blood concentrations of cefuroxime in lower respiratory tract infection.
Authors: C W Havard, R P Bax, T C Samanta, R M Pearson, W Brumfitt, J M Hamilton-Miller, C H Dash
Journal: Thorax (1980)

A detailed pharmacokinetic study of cefuroxime has been carried out. Levels of cefuroxime were determined in the blood, sputum, saliva, and urine of 23 patients receiving parenteral cefuroxime eight hourly for chest infections. Profiles were obtained after the first dose and on the final (fifth) day of treatment. Antibiotic levels in the sputum reached 0.8 mg/l within one hour of the first injection, and were maintained close to this value for six hours. There was a build-up by the fifth day, mean cefuroxime concentrations at this time reaching 1.8 mg/l. This concentration was maintained for a prolonged period. Salivary concentrations were detectable but low (maximum mean value was 0.6 mg/l). Concentrations of antibiotic were significantly higher in the serum than those observed after the same doses in volunteers. In the patients there was no build-up in serum levels between the first and fifth days. The data obtained explain the clinical efficacy of cefuroxime in the treatment of lower respiratory infections, and suggest that a 12-hour schedule may be feasible.
WHAT THE GENERAL PRACTITIONER SHOULD KNOW ABOUT DISEASES OF THE EYE.
Authors: Frank Trester Smith
Journal: JAMA (1894)

In the issue of theJournalof February 3 Dr. W. A. Fisher reviews an article of mine on the above subject read before the Tennessee State Medical Society. In the article I stated that it was not expected that every doctor should become a specialist but that he should understand enough to know his ignorance; that it was not necessary for him to be able to fit glasses but he should understand the main indications for the use of spectacles, viz.: Presbyobia, diminished vision, asthenopia, headache, functional nervous diseases, etc.; he should be able to diagnose between cataract and glaucoma as a cause of poor vision, and also be familiar with the diagnosis of inflammations of the conjunctiva, cornea and iris; he should be informed on the indications and contraindications for the use of atropin, eserin and similar drugs. My article was an endeavor to outline a statement of
Glucose-tolerance Test in Hypertensive Patients
Authors: E. R. Nye
Journal: BMJ (1964)

MEDBRIJOsN 727felt tired, one had visual hallucinations of coloured lights on this dose.This latter side-effect also occurred after five weeks on 100 mg.q.d.s.These side-effects were all readily relieved by reducing the dose.Two of the hypertensive anginal patients on 400 mg.daily have not experienced any side-effects: we have not increased the dose above this level.
Multiple and Infraductal Coarctations of the Aorta
Authors: LAWRENCE I. ZAROFF, ISADORE KREEL, HAROLD J. SOBEL, IVAN D. BARONOFSKY
Journal: Circulation (1959)

Reports of multiple and infraductal coarctations are appearing more frequently in the literature as interest in the treatment of cardiovascular disease grows. A case with 4 distinct coarctations is presented.
General intelligence is central to many forms of talent
Authors: Lloyd G. Humphreys
Journal: Behavioral and Brain Sciences (1998)

Howe et al.'s rejection of traditional discussion of talent is clearly acceptable, but their alternative has a weakness. They stress practice and hard work while referring vaguely to some basic biological substrate. High scores on a valid test of general intelligence provide a cultural-genetic basis for talented performance in a wide variety of specialties, ranging from engineering to the humanities. These choices may be entirely environmentally determined, and the highest levels of achievement do require practice and hard work.
Carotid Cavernous Aneurysm with Fistula
Authors: W. J. Roche
Journal: BMJ (1942)

MEDICAL JOU'RNAL (Oxford Standards Laboratory)-that is, they were type V, W, X, or Z-but pressure of work prevented more detailed identification.The MacConkey agar in use at the laboratory gave a high proportion of positive pates in early cases, when a frag- ment of blood-stained mucus was plated after repeated washing; but results in convalescents, though occasionally
Oliguric Renal Failure
Authors: Kevin G. Barry
Journal: JAMA (1962)

Acute organic renal failure is preceded by a reversible functional failure in most patients. Prompt mannitol therapy reversed functional and prevented total organic failure in 16 of 24 patients treated. A tentative diagnosis of organic failure was based on the findings of prolonged oliguria, low urinary specific gravity, azotemia without azoturia, inappropriate urinary sodium excretion, and an abnormal urinary sediment. The acute intravenous infusion of 12.5 gm. mannitol was supplemented in 13 of the 16 responsive patients to maintain urine flow at 100 ml. per hour; thus, abnormalities of water balance, electrolyte balance, and acid-base balance associated with oliguric renal failure were circumvented. Increasing azotemia and other evidence of organic failure persisted for several days in some patients, but none developed clinical uremia. Mannitol infusion appeared to be a life-saving measure in many patients.
Consumption of coffee during pregnancy: Article raises more questions than it answers
Authors: L. Tsoi
Journal: BMJ (2003)

EDITOR—Wisborg et al's article raises more issues than it settles.1 Firstly, coffee contains not only caffeine but a mixture of different ingredients (milk, sugar, stabilisers, flavour, and other alkaloids from coffee beans). Attributing the result of drinking coffee to just one constituent seems illogical. If Wisborg et al want to prove what they contend, they should contrast the group taking eight cups of ordinary coffee to those taking eight cups …
The social psychology of cognitive repression
Authors: Jennifer J. Freyd
Journal: Behavioral and Brain Sciences (2006)

Erdelyi identifies cognitive and emotional motives for repression, but largely neglects social motivations. Yet social pressure to not know, and implicit needs to isolate awareness in order to protect relationships, are common motives. Social motives may even trump emotional motives; the most painful events are sometimes the most difficult to repress. Cognitive repression may be impacted by social information sharing.
Expression of Vascular Endothelial Growt Factor and Its Receptors fit and KDR in Ovarian Carcinoma
Authors: C. A. Boocock, D. S. Charnock-Jones, A. M. Sharkey, J. McLaren, P. J. Barker, K. A. Wright, P. R. Twentyman, S. K. Smith
Journal: JNCI Journal of the National Cancer Institute (1995)

Two thirds of patients with ovarian carcinoma have advanced disease at diagnosis and have poor progenoses because of the presence of highly invasive carcinoma cells and rapidly accumulating ascitic fluid. Vascular endothelial growth factor (VEGF), a potent mitogen of endothelial cells, is produced in elevated amounts by many tumors, including ovarian carcinomas. The known human receptors for VEGF, fit and KDR, are both cell surface tyrosine kinases and are expressed predominantly on endothelial cells. Acting through these receptors, VEGF may stimulate angio-genesis and promote tumor progression. Purpose: We aimed to clarify the function of VEGF in tumor development by identifying the cells in ovarian carcinoma tissue that express VEGF and its receptors. VEGF, fit, and KDR expression was localized by in situ hybridization and immunohistochemistry in frozen sections of primary tumors from five patients with ovarian carcinoma and from metastases of ovarian carcinoma from three different patients. Reverse transcription followed by polymerase chain reaction (RT-PCR) and an enzyme-linked immunosorbent assay were used to analyze VEGF, fit, and KDR expression in six epithelial cell lines derived from ovarian carcinoma ascites from five additional patients. Messenger RNAs (mRNAs) encoding VEGF, fit, and KDR were detected in primary ascitic cells and in three of four ovarian carcinoma cell lines examined by RT-PCR. Two novel complementary DNAs that may encode truncated, soluble forms of fit were cloned from one primary source. VEGF levels of 20–120 pAf were found in culture media conditioned by the cell lines. Elevated expression of VEGF mRNA was found in all primary tumors and metastases, especially at the margins of tumor acini. VEGF immunoreactivity was concentrated in clusters of tumor cells and patches of stromal matrix. fit immunoreactivity was confined to tumor blood vessels, but fit mRNA was not detected by in situ hybridization. In contrast, KDR mRNA was detected not only in vascular endothelial cells but also in tumor cells at primary malignant sites. VEGF is expressed by tumor cells in primary and metastatic ovarian carcinoma and accumulates in the stromal matrix. Its receptors, fit and KDR, are expressed by some tumor blood vessels; KDR is also expressed by some tumor cells that coexpress VEGF. This is the first localization of KDR expression in nonendothelial cells. Implications: Coexpression of VEGF and KDR by tumor cells in ovarian carcinoma raises the possibility of autocrine stimulation and of therapeutic strategies targeting this receptor-ligand interaction. (J Natl Cancer Inst 8706–516, 1995)
Chemoprevention of Rat Prostate Carcinogenesis by Use of Finasteride or Casodex
Authors: S. Tsukamoto, H. Akaza, S. Imada, K. Koiso, T. Shirai, Y. Ideyama, M. Kudo
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Chemoprevention of Rat Prostate Carcinogenesis by Use of Finasteride or Casodex Get access Sadamu Tsukamoto, Sadamu Tsukamoto *Department of Urology, Institute of Clinical Medicine, University of TsukubaIbaraki, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Hideyuki Akaza, Hideyuki Akaza *Department of Urology, Institute of Clinical Medicine, University of TsukubaIbaraki, Japan Hideyuki Akaza, M.D., Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba City, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Seiki Imada, Seiki Imada *Department of Urology, Institute of Clinical Medicine, University of TsukubaIbaraki, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenkichi Koiso, Kenkichi Koiso *Department of Urology, Institute of Clinical Medicine, University of TsukubaIbaraki, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tomoyuki Shirai, Tomoyuki Shirai First Department of Pathology, Nagoya City UniversityJapan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yukitaka Ideyama, Yukitaka Ideyama Endocrinology and Metabolic Disease Research Laboratory, Institute for Drug Discovery ResearchYamanouchi Pharmaceutical Co. Ltd., Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Masafumi Kudo Masafumi Kudo Endocrinology and Metabolic Disease Research Laboratory, Institute for Drug Discovery ResearchYamanouchi Pharmaceutical Co. Ltd., Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 11, 7 June 1995, Pages 842–843, https://doi.org/10.1093/jnci/87.11.842 Published: 07 June 1995 Article history Received: 25 January 1995 Revision received: 27 March 1995 Accepted: 06 April 1995 Published: 07 June 1995
Familial sea-blue histiocytosis with cutaneous involvement. A case report with ultrastructural findings
Authors: A.M. ZINA, S. BUNDINO
Journal: British Journal of Dermatology (1983)

Journal Article Familial sea‐blue histiocytosis with cutaneous involvement. A case report with ultrastructural findings Get access A.M. ZINA, A.M. ZINA Institute of Dermatology, Turin University, Italy Alberto Maria Zina, Clinica Dermatologica, Via Cherasco 23, 10126 Torino, Italy. Search for other works by this author on: Oxford Academic Google Scholar S. BUNDINO S. BUNDINO Institute of Dermatology, Turin University, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 3, 1 March 1983, Pages 355–361, https://doi.org/10.1111/j.1365-2133.1983.tb03975.x Published: 01 March 1983
Diffuse High Intensity PD–L1 Staining in Thymic Epithelial Tumors
Authors: Sukhmani K. Padda, Jonathan W. Riess, Erich J. Schwartz, Lu Tian, Holbrook E. Kohrt, Joel W. Neal, Robert B. West, Heather A. Wakelee
Journal: Journal of Thoracic Oncology (2014)
REDUCTION IN CONCENTRATION OF TOTAL SERUM-BILIRUBIN IN OFFSPRING OF WOMEN TREATED WITH PHENOBARBITONE DURING PREGNANCY
Authors: HaroldM. Maurer, JamesA. Wolff, M. Finster, PaulJ. Poppers, E. Pantuck, R. Kuntzman, A.H. Convey
Journal: The Lancet (1968)
Effects of 12 months of intense exercise training on ischemic ST-segment depression in patients with coronary artery disease.
Authors: A A Ehsani, G W Heath, J M Hagberg, B E Sobel, J O Holloszy
Journal: Circulation (1981)

This study was undertaken to determine whether adaptation to 12 months of intense endurance exercise training could alter the relationship between the product of heart rate and systolic blood pressure (double product) and the extent of ischemic ST-segment depression during exercise in patients with coronary artery disease. True (i.e., not symptom-limited) maximum oxygen uptake capacity increased from 25.5 +/- 4.2 ml/kg/min (mean +/- SD) to 35.3 +/- 4.4 ml/Kg/min with training. The maximum degree of ST-segment depression during exercise averaged 0.20 +/- 0.04 mV before and 0.16 +/- 0.08 mV after training despite a 20% increase in maximum double product. The double product at which ST depression (0.1 mV) first appeared was 22% greater after training. The extent of ST-segment displacement at the same double product was less after training. These findings suggest that training, if sufficiently intense and prolonged, can result in a reduction in myocardial ischemia at the same or a higher double product.
Disability and Coal Workers' Pneumoconiosis
Authors: D. Davies
Journal: BMJ (1974)

The Industrial Injuries Advisory Council has reaffirmed the view that simple pneumoconiosis does not produce disability or shorten life. This is often true but, without overlooking the importance of chronic bronchitis, such conclusions are wrong in many instances. Chronic bronchitis is probably commoner in miners without pneumoconiosis than in those with it, and an uneven distribution of bronchitis may mask the effects of pneumoconiosis. Cough and sputum in a miner with pneumoconiosis are not always due to chronic bronchitis. Disability is usually judged on measurement of vital capacity and forced expiratory volume, factors which cannot be expected to be significantly altered by simple pneumoconiosis alone. Other tests may show abnormalities which lead to ventilation and perfusion inequalities and to an increase in the ventilatory cost of exercise. Focal emphysema, often a consequence of simple pneumoconiosis, develops slowly and its influence on disability is delayed. Disagreements arise because epidemiologists expect all lungs with simple pneumoconiosis react in the same way, and they want a quantitative relation between simple pneumoconiosis and emphysema before attributing one to the other. There are major difficulties in assessing disability but there is little justification for the regular application of the rule that if the results of ventilatory tests are normal disability is not present and if they are abnormal this is due to something other than simple pneumoconiosis.
Abstract 3980: Hypoxia-induced microRNA-424 targets CUL2 to stabilize HIF-α isoforms and promotes angiogenesis
Authors: Indira V. Subramanian, Goutam Ghosh, Julia Nguyen, Xiaoxiao Zhang, Hemant P. Joshi, Yan Zeng, Sundaram Ramakrishnan
Journal: Cancer Research (2011)

Abstract Chronic hypoxia, a hallmark of many tumors, is associated with angiogenesis and tumor progression. Adaptive changes to oxygen availability are critical for cell survival and homeostasis. Cells respond to hypoxia by modulating oxygen-sensing transducers that stabilize the transcription factor hypoxia-inducible factor 1α (HIF-1α), which transactivates genes governing angiogenesis and metabolic pathways. Oxygen-dependent changes in HIF-1α levels are regulated by proline hydroxylation and proteasomal degradation. Here we provide evidence for a novel mechanism regulating HIF-1α and HIF-2α levels in endothelial cells during hypoxia. Hypoxia differentially increased microRNA-424 (miR-424) levels in microvascular EC, HUVEC and EC progenitor cells purified from the blood. miR-424 targeted cullin 2 (CUL2), a scaffolding protein critical to the assembly of the ubiquitin ligase system, thereby stabilizing HIF-α isoforms. Hypoxia-induced miR-424 in EC was regulated by PU.1-dependent transactivation. PU.1 expression was in turn controlled by RUNX-1 and C/EBPα. Knocking down either C/EBPα or RUNX-1 or PU.1 attenuated hypoxia-driven expression of miR-424 and nuclear translocation of HIF-1α. Furthermore, miR-424 promoted angiogenesis in vitro and in mice, which was blocked by specific morpholinos. These results suggest that miR-424 plays an important physiological role in angiogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3980. doi:10.1158/1538-7445.AM2011-3980