tbuckley/cabot-search huggingface dataset:
Disinfectants and Plastic Mop Heads
Authors: D. A. Leigh, C. Whittaker
Journal: BMJ (1967)

respects: completeness of relief achieved, relief of anorexia and lassitude, and relief of symptoms following abdominal or pelvic irradiation.All these are the most resistant to relief.Only by the detailed analysis of such criteria in large series of cases will the value of drugs in radiation sickness be clarified.-Iam, etc.,
Ana o 3, an important cashew nut (Anacardium occidentale L.) allergen of the 2S albumin family
Authors: Jason M. Robotham, Fang Wang, Vanessa Seamon, Suzanne S. Teuber, Shridhar K. Sathe, Hugh A. Sampson, Kirsten Beyer, Margaret Seavy, Kenneth H. Roux
Journal: Journal of Allergy and Clinical Immunology (2005)
Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells
Authors: Stéphanie Grosse, Nicolas Huot, Charlotte Mahiet, Sylvain Arnould, Sébastien Barradeau, Diane Le Clerre, Isabelle Chion-Sotinel, Cécile Jacqmarcq, Benoît Chapellier, Ayla Ergani, Carole Desseaux, Frédéric Cédrone, Emmanuel Conseiller, Frédéric Pâques, Marc Labetoulle, Julianne Smith
Journal: Molecular Therapy (2011)

Herpes simplex virus type 1 (HSV1) is a major health problem. As for most viral diseases, current antiviral treatments are based on the inhibition of viral replication once it has already started. As a consequence, they impair neither the viral cycle at its early stages nor the latent form of the virus, and thus cannot be considered as real preventive treatments. Latent HSV1 virus could be addressed by rare cutting endonucleases, such as meganucleases. With the aim of a proof of concept study, we generated several meganucleases recognizing HSV1 sequences, and assessed their antiviral activity in cultured cells. We demonstrate that expression of these proteins in African green monkey kidney fibroblast (COS-7) and BSR cells inhibits infection by HSV1, at low and moderate multiplicities of infection (MOIs), inducing a significant reduction of the viral load. Furthermore, the remaining viral genomes display a high rate of mutation (up to 16%) at the meganuclease cleavage site, consistent with a mechanism of action based on the cleavage of the viral genome. This specific mechanism of action qualifies meganucleases as an alternative class of antiviral agent, with the potential to address replicative as well as latent DNA viral forms.
Clinicopathologic significance of HBV X, core promoter, precore mutants in patients with chronic HBV infection
Authors: Youn-Jae Lee, None Young II Yang, Won Hee Jang, Kye Hyung Paik, Yeun Sik Jang, Sang Hyuk Lee, Sang Young Seol, Jung Myung Chung
Journal: Journal of Hepatology (2001)
Correction: Small Intestine Structure and Infection with Human Immunodeficiency Virus (HIV)
Authors: Reiner Ullrich
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 December 1989Correction: Small Intestine Structure and Infection with Human Immunodeficiency Virus (HIV)Reiner Ullrich, MB, Martin Zeitz, MDReiner Ullrich, MBSearch for more papers by this author, Martin Zeitz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-11-954_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Unfortunately, we have discovered an error in our article (1) published in the 1 July 1989 issue. In the last paragraph of the Results section on page 19, the sixth sentence is incorrect and should be corrected to read: "There were two patients who did not have intestinal infection but had HIV-antigen p24 in the mucosa and both had minimal numbers of mitotic figures per crypt (P< 0.025)."...Reference1. UllrichZeitzHeiseL'ageHöffkenRiecken RMWMGE. Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): evidence for HIV-induced enteropathy. Ann Intern Med. 1989;111:15-21. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Klinikum Steglitz of the Free University of Berlin D-1000 Berlin 45, Federal Republic of Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHeavy-Chain Disease 1 December 1989Volume 111, Issue 11Page: 954-954KeywordsHIVMucous membranesSmall intestine Issue Published: 1 December 1989 PDF DownloadLoading ...
Inflammation, stress, and diabetes
Authors: Kathryn E. Wellen, Gökhan S. Hotamisligil
Journal: Journal of Clinical Investigation (2005)

Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity. It is now clear that obesity is associated with a state of chronic low-level inflammation. In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes. We also consider mechanisms through which the inflammatory response may be initiated and discuss the reasons for the inflammatory response in obesity. We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease.
THE MEDICAL NEEDS OF SYRIA.
Authors: LABIB B. JUREIDINI
Journal: JAMA (1897)

The attention of the civilized world has lately been awakened to a certain corner of it where crime and massacre have become rife, and where fanaticism and tyranny have been maturing their most horrible results. Information about the lands in which these scenes have been, and are being enacted, and about the nations that are groaning under the iron hand of the unspeakable Turk, now assumes a new aspect of interest to all, especially to the sympathetic hearts of the American people. To physicians and all others interested in their noble profession, all that pertains to the medical conditions and needs of these countries will be among the first topics of interest. It shall be my effort tonight to present before you the medical needs of Syria, my native country, which, though not undergoing the same convulsions that are now tearing up other sections of the Ottoman Empire, may yet
Free radicals and reperfusion arrhythmias. Commentaries on this month's Controversy articles From Peggy Barrington
Authors: P. L Barrington
Journal: Cardiovascular Research (1994)

Journal Article Free radicals and reperfusion arrhythmias. Commentaries on this month's Controversy articles From Peggy Barrington Get access Cardiovascular Research, Volume 28, Issue 3, March 1994, Pages 424–425, https://doi.org/10.1093/cvr/28.3.424 Published: 01 March 1994
AIDS and global justice
Authors: G. Yamey
Journal: BMJ (2002)

> “The bottom line is, the people who are dying from AIDS don't matter in this world.”1

Remember HIV/AIDS? This theme issue of the BMJ challenges the global community to overcome its amnesia and fatigue, mobilise its ample collective resources, and make 2002 the turning point in tackling HIV.

The theme that dominates these pages is the need for justice. In his Theory of Justice , John Rawls, perhaps the most important moral philosopher of the 20th century, argued that justice is required when there is a struggle for scarce resources and when life is brief.2 Both of these conditions are met in those countries devastated by HIV. Authors in this week's BMJ demand actions that are based on justice: the distribution of antiretroviral drugs to the world's poorest people; the empowerment of women; the urgent search for an HIV vaccine; and the care and education of children orphaned by AIDS.

Wealthy countries must take the lead in acting justly. Their colonisation of the regions now struggling with rising HIV rates, like India and Africa, left behind a legacy …
AN IMMUNOLOGICAL STUDY OF PNEUMOCOCCUS MUCOSUS
Authors: Frederic M. Hanes
Journal: The Journal of Experimental Medicine (1914)

1. The organisms described by Schottmüller under the name Streptococcus mucosus represent a well defined group with characteristics which indicate a closer relationship to the pneumococci than to the streptococci. 2. The members of this group are specifically agglutinable when treated according to the method of Porges. They do not agglutinate when subjected to the usual agglutination methods. 3. Complement fixation experiments with these organisms, compared with similar experiments with two varieties of pneumococci and two streptococci, indicate that they are closely related to the pneumococci. 4. No protection of mice against Pneumococcus mucosus by means of specific immune sera could be demonstrated. 5. The name Pneumococcus mucosus should be adopted for this group instead of Streptococcus mucosus.
Relationship between alcoholic relapse, non compliance and histological lesions after liver transplantation (LT) for alcoholic cirrhosis (AC)
Authors: Monika Hurtova, Jean-Charles Duclos-Vallee, Valerie Delvart, Vincent Karam, Faouzi Saliba, Philippe Ichai, Cyrille Feray, Catherine Guettier, Henri Bismuth, Didier Samuel
Journal: Journal of Hepatology (2002)
Minimally invasive coronary bypass surgery in octogenarians: Perioperative outcome and comparison with younger age groups
Authors: S.C. Stamou, G. Dangas, P.C. Hill, A.J. Pfister, M.K.C. Dullum, S.W. Boyce, A. Bafi, J.M. Garcia, P.J. Corso
Journal: European Journal of Heart Failure (2000)
Differing uptake of emulsion triglyceride by the fed and fasted rat liver.
Authors: S H Quarfordt, J Hanks, F Shelburne, B Schirmer
Journal: Journal of Clinical Investigation (1982)

The recycling perfusion of a fasted rat liver with an apoprotein E-enriched synthetic triglyceride emulsion revealed a significantly greater hepatic uptake of both the apoprotein and the triglyceride than did the liver of a chow-fed animal. This greater hepatic triglyceride uptake by the perfused fasted liver in comparison to the fed was also noted for emulsions containing no added apoprotein or supplemented with both the E and CIII-1 proteins. However, no difference in the uptake of the triglyceride emulsion was seen for the fed and fasted livers when evaluated by a nonrecycling single pass perfusion. The isolated hepatocyte plasma membranes from fasted rats failed to demonstrate enhanced binding of apoprotein or lipid when compared to those from fed animals. If the residual E loaded triglyceride emulsion was recovered from the recycling perfusates of fed and fasted livers and evaluated in a non-recycling single-pass system, the emulsion from the fasted perfusion was cleared as facilely as previously, whereas that from the fed was less actively cleared. The emulsions retrieved from the perfusion of the fed liver contained significantly more protein than did the fasted; in particular apo C. This apparent alteration of emulsion apoproteins by the fed liver possibly results in a less active hepatic retrieval and may be important in downregulating the entry of lipoprotein triglyceride in the postabsorptive liver.
Glucagon Responses to Hypoglycemia in Type I Diabetic Men After 24-hour Glucoregulation by Glucose-controlled Insulin Infusion
Authors: John W Ensinck, Robert A Kanter
Journal: Diabetes Care (1980)

To determine if the attenuated glucagon response to insulin-induced glucopenia characteristic of type I diabetic patients might be restored to normal by optimizing glucose “control,” four type I diabetic men were studied after precise glucoregulation by means of a glucose-controlled insulin infusion system (GCIIS). Plasma glucose and immunoreactive glucagon (IRG) levels were measured before and after an intravenous bolus of insulin, and the results were compared with those in six healthy young men and in five healthy, type I diabetic patients who were receiving conventional insulin therapy. In comparison to the augmented secretion of IRG in the normals after glucopenia, the conventionally treated diabetic subjects had a trivial increase in IRG levels despite similar decrements in plasma glucose levels. In four diabetic men, plasma glucose levels were maintained within euglycemic ranges by GCIIS throughout 24 h, and, immediately thereafter, their IRG responses to insulin-evoked hypoglycemia were quantitatively indistinguishable from the type I diabetic patients who had not been treated by GCIIS. These observations contrast to evidence that A-cell responses to signals such as glucose or amino acids are partially or completely restored by short- or long-term insulin administration. It is inferred that this abnormality reflecting a possible defect in A-cell glucose recognition may be a persistent abnormality in patients with type I diabetes.
Studies of intestinal lymphoid tissue. XIV--HLA status, mucosal morphology, permeability and epithelial lymphocyte populations in first degree relatives of patients with coeliac disease.
Authors: M N Marsh, I Bjarnason, J Shaw, A Ellis, R Baker, T J Peters
Journal: Gut (1990)

Fifty two first degree relatives of patients with coeliac disease were investigated for HLA status, small intestinal permeability, and mucosal morphology together with the size of the intraepithelial lymphocyte pool and indices of lymphocyte activation, in an attempt to identify genetically determined markers of the disease. Thirty eight per cent of these subjects had increased intraepithelial lymphocyte populations and a highly significant association with HLA-DR3 compared with controls. Their intestinal permeability to 51chromium-labelled ethylenediamine tetraacetate was invariably normal and there was no evidence of abnormal mucosal architecture, increased crypt cell mitotic activity or lymphocyte 9activation9. Although increased intraepithelial lymphocyte counts clearly do not cause alterations in intestinal structure or function, it is likely that this parameter together with the HLA-DR3 status identifies a genetically determined predisposition to the disease which may only become clinically evident with larger doses of ingested gluten.
Is early remission associated with improved survival or is arthritis persistency associated with increased mortality in early arthritis? Comparisons with the general population
Authors: Jessica A B van Nies, Annette H M van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2013)

We read the article of Scire et al with interest,1 evaluating the association between remission and mortality in patients with inflammatory polyarthritis. This study shows that patients achieving remission early in the disease course have an improved survival rate compared with patients never achieving remission. Based on this observation, the authors conclude that achieving remission early in the disease influences the long-term outcome. The question arises which processes underlie their observation. Rheumatoid arthritis (RA) has been associated with an increased mortality risk, which has been attributed to the effects of long-term inflammation.2 We hypothesised that the observation in which patients with remission have an improved survival rate might actually be driven by the association between prolonged inflammation and increased mortality risk.

We addressed this hypothesis by taking advantage of long-term outcomes of 556 patients with early undifferentiated arthritis or RA that were included in the Leiden Early Arthritis Clinic between 1993 and 1998.3 Treatment in this era was delayed and disease-modifying antirheumatic drugs (DMARDs) were mild. We previously observed that patients included in this era had an increased mortality rate …
Role of glycolytic flux in effect of glucose in decreasing fatty-acid-induced release of lactate dehydrogenase from isolated coronary ligated rat heart
Authors: L. H. OPIE, O. L. BRICKNELL
Journal: Cardiovascular Research (1979)

The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of glucose in this system. Provision of glycolytic ATP from increased glycolytic flux may be one important factor.
National Surveillance of AIDS in Health Care Workers
Authors: Alan R. Lifson
Journal: JAMA (1986)

Information obtained for all persons with the acquired immunodeficiency syndrome (AIDS) reported to the Centers for Disease Control, Atlanta, includes a question about employment in a health care or clinical laboratory setting. As of May 1, 1986, a total of 922 (5.5%) of 16 748 adults with AIDS reported employment in such settings. Ninety-five percent of these health care workers belonged to recognized high-risk groups for AIDS; the proportion with "no identified risk" has not increased with time. All AIDS patients (including health care workers) who do not belong to high-risk groups are referred for further investigation. Of 88 health care workers initially reported with no identified risk, ten were from countries where heterosexual transmission is believed to play a major role; additional information was unobtainable or incomplete for 17 individuals. Of 61 persons on whom interviews or other follow-up information was obtained, 44 (73%) were reclassified. Specific occupational exposures that could be implicated as the source of human immunodeficiency virus infection were not identified for any health care workers with AIDS. A review of surveillance data supports other studies indicating that the risk of human immunodeficiency virus transmission in the occupational setting is low. (<i>JAMA</i>1986;256:3231-3234)
GASTRO 2009 report: putting endoscopy into perspective
Authors: I. Papanikolaou, T. Rösch
Journal: Endoscopy (2010)

The 17th United European Gastroenterology Week (UEGW), held in London in November 2009, was jointly organized by the United European Gastroenterology Federation, the World Gastroenterology Organization, the World Organization of Digestive Endoscopy, and the British Society of Gastroenterology as a combined meeting with the World Congress of Gastroenterology under the name GASTRO 2009. Various abstracts on endoscopic subjects were presented, many of which concentrated on innovations and new techniques, whereas others highlighted topics with an impact on clinical practice. This report focuses on oral presentations, as well as a few presented posters, which demonstrate latest advancements and research in gastrointestinal endoscopy and attempts to briefly review them in the light of recent literature.
Protracted cutaneous disorders in association with low CD4+ lymphocyte counts
Authors: H.A. KURWA, R. MARKS
Journal: British Journal of Dermatology (1995)

Journal Article Protracted cutaneous disorders in association with low CD4+ lymphocyte counts Get access H.A. KURWA, H.A. KURWA Department of Dermatology, University of Wales College of Medicine, Health Park, Cardiff CF4 4XN, U.K. Dr H.A.Kurwa, Department of Dermatology. The Royal London Hospital. Whitechapel, London E1 1BB, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. MARKS R. MARKS Department of Dermatology, University of Wales College of Medicine, Health Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 4, 1 October 1995, Pages 625–629, https://doi.org/10.1111/j.1365-2133.1995.tb02717.x Published: 01 October 1995 Article history Accepted: 02 November 1994 Published: 01 October 1995
Iatrogenic Giant Osborn Waves
Authors: Antonios N. Pavlidis, Antreas Giannakopoulos, Athanasios J. Manolis
Journal: Circulation (2010)

A 57-year-old man was admitted after an out-of-hospital cardiac arrest.He received bystander basic life support followed by prolonged resuscitation at the emergency department and was subsequently transferred to the intensive care unit under mechanical ventilation.Therapeutic cooling was introduced, and his core temperature was monitored with a rectal thermometer.As a result of false high temperature readings secondary to sensor malfunction, cooling procedures were intensified and severe ECG changes appeared on the cardiac monitor.The rectal thermometer was replaced, and a core temperature of 27°C was recorded.ECG demonstrated giant Osborn waves that progressively diminished once rewarming was initiated (Figure).Osborn or J wave is a common ECG finding in hypothermia, appearing as a slow upright deflection between the end of the QRS complex and the early portion of the ST segment.Hypercalcemia, vasospastic angina, Brugada syndrome, and subarachnoid hemorrhage can demonstrate a similar ECG pattern.
MULTIPLE SELF CONCEPTS AS EFFECTED BY MOOD STATES
Authors: A. Z. ORZECK, C. MCGUIRE, E. D. LONGENECKER
Journal: American Journal of Psychiatry (1958)

An experiment was performed to study the hypothesis that two distinct selves occur when moods are varied. Following a definition of the term "self" an experiment was designed to produce hypnotically two distinct sell concepts by the induction of the moods of depression and elation. Twenty Ss. responded to an identical self-reference scale 3 times, first during a waking state, then under hypnotic depression, followed by hypnotic elation. Memory was controlled hypnotically. The scale consisted of 100 items evenly divided for adjustment and maladjustment. Chi-square analyses for each S. revealed that 14 Ss. apparently shifted orientation while 6 Ss. did not. It was speculated that there was considerable similarity between these artificially induced value orientations and actual case recordings.
Examples of Complementary Roles of Abdominal CT and Radiocolloid Liver Imaging
Authors: WEI-JEN SHIH, CHRISTINE RILEY
Journal: Clinical Nuclear Medicine (1989)

Two cases are reported in which well-defined lesions of the liver were seen in radiocolloid liver imagings but not in the concurrent abdominal CT images. The results of autopsy confirmed the diagnosis of hepatoma in one and metastatic disease In the other. The third case, referred for a Tc–99m SC liver–spleen Image because of a suboptimal abdominal CT owing to artifact, showed a normal liver. In certain clinical situations, radiocolloid imaging provides a complementary role to CT in the detection or confirmation of hepatic lesions and, in occasional patients, is superior to CT.
Identification of Unexpected Nonatherosclerotic Cardiovascular Disease With Coronary CT Angiography
Authors: Thomas Knickelbine, John R. Lesser, Tammy S. Haas, Eric R. Brandenburg, B. Kelly Gleason-Han, Björn Flygenring, Terrence F. Longe, Robert S. Schwartz, Barry J. Maron
Journal: JACC. Cardiovascular imaging (2009)
631 Influence of the predisposing DRB1*08 allele and of the protective HLA-DRB1*11 allele over the expression of primary biliary cirrhosis-specific anti-mitochondrial and anti-nuclear reactivities
Authors: P. Invernizzi, D.P. Bogdanos, I. Bianchi, E. Meda, C. Liaskos, A.K. Burroughs, M. Zuin, D. Vergani
Journal: Journal of Hepatology (2006)
Vicissitudes of Depressed Mood During Four Years of Medical School
Authors: David C. Clark
Journal: JAMA (1988)

We describe the vicissitudes of depressed mood for one medical school class that was assessed repeatedly overtime, from the first day of medical school until several months short of graduation, using the Beck Depression Inventory (BDI). Using an arbitrarily defined BDI cutoff point of 14 or greater, at least 12% of the class showed considerable depressive symptoms at any assessment during the first three years; the largest fraction (25%) was symptomatic near the end of the second year. The median class BDI score increased almost threefold during the first two years. Students were likely to be in a similar class ranking at all assessments, indicating that for many students dysphoric mood was enduring. Those with BDI scores of 21 or greater were more likely to quit medical school. Students with high scores for dysphoria were not more likely to evidence a family history of major depression or concomitant substance abuse. Women medical students were not more vulnerable to depressed mood than men.