tbuckley/cabot-search huggingface dataset:
Independent Medical Service
Authors: W. Eade, H. Savery, C. D. G. L. Shimmin
Journal: BMJ (1965)

bewitching a client to death.Furthermore, suggestions of death directly implanted into the impressionable minds of young children may well prove to be particularly harmful and even disastrous, as the " Labrador case " (7 August, p. 363) so tragically illustrates.In order to collect information with a view to possible further exploration of this sub- ject, I would be interested to investigate a sample of fortune-tellers in this country who would be prepared to submit their forecasting methods to critical exposition.Secondly, I would be interested to hear from any doctor who knows of patients with anxieties resulting from foreknowledge, death premonitions, or taboo-and would welcome facts about any other patients who may have been scared or scared themselves to death.It would, of course, be essential to compare the reports with cases in which the predicted occurrence of death at a certain time was not fulfilled.Thirdly, I would like to be acquainted with the findings of any similar research which may possibly have already been undertaken on this interesting topic.-Iam, etc.,
THE PATIENT IN COMMERCIAL JET AIRCRAFT
Authors: Robert B. Stonehill
Journal: JAMA (1960)

Four principal areas of difficulty in air travel for patients are air sickness, pressure alterations with ascent to altitude, decreased concentration of oxygen at high altitudes, and anxiety. Diabetics and patients flying after abdominal surgery should avoid air sickness. There are effective antiemetics, and the smoother jet flight will minimize the problem. Patients with intestinal obstruction; pneumoperitoneum or pneumothorax; and ear, nose, or throat disorders may have serious difficulty because of the change in barometric pressure in jet flight. Decreased is inadequately compensated in patients with significant lung disease, cardiac failure, significant anemia, or histotoxic states. Anxiety, oxygenation of hemoglobin at high altitudes which can increase the cardiac work load, is best allayed by the physician-patient relationship and the physician's expressed confidence that the trip will be uneventful. With few exceptions, aeromedical problems of jet flying are similar to aeromedical problems in general, and most patients who can travel at all can travel more comfortably by air.
Endocarditis and Musculoskeletal Manifestations
Authors: ROBERT G. IRVIN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Endocarditis and Musculoskeletal ManifestationsROBERT G. IRVIN, M.D., ROBERT M. SADE, M.D.ROBERT G. IRVIN, M.D.Search for more papers by this author, ROBERT M. SADE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-578_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Churchill, Geraci, and Hunder (Ann Intern Med 87:754-759, 1977) have suggested that arterial embolism may be a causal factor in myalgias of the lower extremities in patients with endocarditis. Objective evidence for embolization was not reported, however. We have recently seen a patient with infective endocarditis, lower extremity myalgias, and documented arterial emboli.An 18-year-old white boy with congenital aortic stenosis and insufficiency underwent aortic valve replacement with a porcine heterograft in August 1977. Within 3 weeks after hospital discharge, he developed a fever and was readmitted. At admission he had no peripheral manifestations of endocarditis or...Reference1. UNTERERERHANNA WB: Endocarditis and osteomyelitis caused by Aerococcus viridans. Mt Sinai J Med NY 43:248, 1976 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical University of South Carolina Charleston, SC 29403 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPost-operative aspergillosisErkrankungen des EndokardsAspergillusaortitis after cardiac surgeryErkrankungen des EndokardsErkrankungen des EndokardsSuccessful treatment of post-mitral valve annuloplasty aspergillus flavus endocarditisRheumatological manifestations of infective endocarditis.Severe Backache as a Presenting Sign of Bacterial EndocarditisAortotomy site infections: case presentation and review of the literature 1 April 1978Volume 88, Issue 4Page: 578-578KeywordsAortic valve replacementEndocarditisFeversMyalgiaStenosis Issue Published: 1 April 1978 PDF DownloadLoading ...
ANALYSES OF INTRA-LEFT VENTRICULAR (LV) FLOW DYNAMICS IN PATIENTS WITH NORMAL AND IMPAIRED LV FUNCTION USING PHASE-RESOLVED 3D CINE PHASE-CONTRAST MRI (4D-FLOW MRI)
Authors: Kenichiro Suwa, Takeji Saitoh, Makoto Sano, Mamoru Nobuhara, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Marcus Alley, Yasuo Takehara, Harumi Sakahara, Hideharu Hayashi
Journal: Journal of the American College of Cardiology (2014)
Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition
Authors: Annette M Vogl, Marisa M Brockmann, Sebastian A Giusti, Giuseppina Maccarrone, Claudia A Vercelli, Corinna A Bauder, Julia S Richter, Francesco Roselli, Anne-Sophie Hafner, Nina Dedic, Carsten T Wotjak, Daniela M Vogt-Weisenhorn, Daniel Choquet, Christoph W Turck, Valentin Stein, Jan M Deussing, Damian Refojo
Journal: Nature Neuroscience (2015)
Deposition of carbenicillin aerosols in cystic fibrosis: effects of nebuliser system and breathing pattern.
Authors: S P Newman, G Woodman, S W Clarke
Journal: Thorax (1988)

Antibiotic aerosol treatment is successful in treating Pseudomonas infection in some patients with cystic fibrosis, but the amount of drug reaching the lungs is unknown. The deposition patterns of carbenicillin aerosols delivered from two commercially available nebuliser systems (the Turret nebuliser plus Maxi compressor and the Inspiron nebuliser plus Traveller compressor) have been compared in six patients with cystic fibrosis during tidal breathing. The aerosol mass median diameters were 3.2 and 7.3 microns. In addition, the aerosol from the Turret-Maxi nebuliser system was inhaled by a combination of tidal and deep breathing. After two minutes9 breathing via a mouthpiece the mean (SEM) deposition in the lungs was 15.60 (1.5) mg carbenicillin with the Turret nebuliser plus Maxi compressor, but only 6.54 (1.09) mg with the Inspiron nebuliser plus Traveller compressor; the distribution pattern within the lung was significantly more peripheral with the former nebuliser system. These differences may be ascribed partly to the smaller droplet size from the Turret system and partly to the higher nebulisation rate from the more powerful Maxi compressor. Tidal plus deep breathing produced a further small but non-significant increase in lung aerosol deposition. A seventh patient, who failed to complete the trial, had little aerosol deposited in his lungs because he inhaled through his nose. These results emphasise the importance of correct selection of nebuliser equipment for antibiotic aerosol treatment.
Cardiac conditioning ameliorates cardiac dysfunction associated with renal hypertension in rats.
Authors: T F Schaible, G J Ciambrone, J M Capasso, J Scheuer
Journal: Journal of Clinical Investigation (1984)

To explore the effect of physiologic hypertrophy superimposed on pathologic hypertrophy, hearts from female control rats (C), renal hypertensive rats (H), rats conditioned with a 10-12 wk swimming program (Sw), and hypertensive rats trained by the swimming program (H-Sw) were perfused in an isolated working rat-heart apparatus. Systolic blood pressure was approximately 100 mmHg in C and Sw and was 160 mmHg in H and H-Sw. The swimming program had no effect on blood pressure. Compared with C, heart weight was increased by 30% in Sw, 47% in H, and 77% in H-Sw. At high preload and afterload, cardiac output (milliliters per gram dry LV weight) was decreased in H, increased in Sw, and partially restored towards normal in H-Sw. Ejection fraction, percent fractional shortening, and mean velocity of circumferential fiber shortening were enhanced in Sw, depressed in H, and normalized in H-Sw when compared with C. Coronary flow and myocardial oxygen consumption in this series of hearts were depressed in H, with no restoration in H-Sw, but coronary effluent lactate/pyruvate ratios were only elevated in the hearts of H-Sw. Coronary vascular responses were examined in a second series of experiments which used microspheres. In this series, the depressed coronary flow observed in H was partially restored towards normal in H-Sw and the inner/outer myocardial flow ratio was normal when hearts were perfused at 140 cm aortic pressure but was somewhat depressed in both H and H-Sw when the hearts were perfused at 80 cm aortic pressure. These studies demonstrate that hypertrophic hearts from renal hypertensive rats have diminished coronary flow and depressed cardiac function when they are studied in the isolated working heart apparatus, yet there is no evidence of myocardial ischemia. Superimposition of a chronic swimming program results in increased hypertrophy but restoration of cardiac function partially or completely to normal. Thus, pathologic and physiologic hypertrophy are biologically distinct entities. Physiologic hypertrophy may partially ameliorate the defects associated with pathologic hypertrophy.
Effects of coronary occlusion on cardiac and body surface PQRST isoarea maps of dogs with abnormal activation simulating left bundle branch block.
Authors: M Hirai, M J Burgess, C W Haws
Journal: Circulation (1988)

The possibility of detecting myocardial infarction in the presence of left bundle branch block by analysis of cardiac and body surface PQRST isoarea maps was studied in nine open-chest and six closed-chest dogs. Recordings were taken during supraventricular drive or right atrial plus right ventricular pacing in control periods and at intervals for up to 10 hr after left anterior descending coronary artery occlusion. Right ventricular pacing was used to simulate left bundle branch block. Myocardial infarction was documented with triphenyl tetrazolium staining. The PQRST areas during supraventricular drive and right atrial plus right ventricular pacing were highly correlated to each other both before and after coronary occlusion. The PQRST isoarea maps after coronary occlusion showed a strong pole overlying the ischemic area on the cardiac surface in open-chest animals and over the left anterior thorax in closed-chest animals. The PQRST pole was positive during the first 1 to 2 hr of occlusion and became negative after several hours. The findings demonstrate that localized abnormalities due to ischemia and infarction are manifest in body and cardiac surface PQRST isoarea maps of both supraventricular complexes and right ventricular paced complexes. The findings suggest that PQRST isoarea maps may aid in identification and localization of ischemic or infarcted myocardium in the setting of abnormal activation such as left bundle branch block.
When You Only Live Twice
Authors: S Viskin, B Belhassen
Journal: New England Journal of Medicine (1995)

A 22-year-old man was apparently in good health until, suddenly and without warning, he lost consciousness in the back seat of a car. The patient was rushed to a nearby clinic, where he was found to be apneic and to have no pulse. Electrocardiographic monitoring revealed ventricular fibrillation. Cardiopulmonary resuscitation was carried out, and after repeated direct-current shocks, sinus rhythm was restored. The patient was hospitalized.The causes of sudden death are many and are usually presented in double-page, small-print tables in textbooks. The absence of symptoms before the catastrophic event in this case allows me to concentrate . . .
P75 Physical impairment and Frailty in Patients with Chronic Obstruction Pulmonary Disease (COPD): Abstract 75 Table 1
Authors: NS Gale, AM Albarrati, I Munnery, M Munnery, R Tal-Singer, R Hubbard, JR Cockcroft, DJ Shale
Journal: Thorax (2012)

<h3>Background</h3> COPD is a multi-system disease, which has been linked to premature physiological ageing. Recognised co-morbidities include increased risk of cardiovascular events and osteoporosis, loss of muscle mass, function and impaired quality of life (QoL). The Chronic Geriatric Assessment (CGA) has been used to measure impairments, frailty and predict outcomes in older individuals. We hypothesised that the CGA would be greater in COPD than comparator subjects, and would relate to physical function and QoL in patients with COPD. <h3>Methods</h3> As part of the Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE)* longitudinal study, 300 patients with COPD (149 male) and 50 (28 male) comparators free from respiratory disease were evaluated. In all subjects spirometry, BMI, handgrip, 6 minute walk distance (6MWD), timed up and go (TUG), and the CGA were determined. The CGA is a 20 item interviewer administered questionnaire, which quantifies, physical, functional, psychosocial and medical impairments, scored out of 61, higher scores indicate more impairment. Health-related QoL was measured in patients using the St George’s Respiratory Questionnaire (SGRQ) and MRC breathless was recorded. <h3>Results</h3> Patients and comparators were similar in age, gender and BMI, but differed in lung function, grip strength, 6MWD, TUG and all domains of the CGA (Table 1). There was no difference in gender for BMI and CGA score. In patients, the total CGA score related to FEV1% r= –0.187, handgrip r= –0.335, 6MWD r= –0.548, TUG r=0.506, MRC breathlessness r=0.351 and number of exacerbations per year r=0.313 (all p&lt;0.05) but did not relate to age. Of these, stepwise multiple regression showed that 6MWD, TUG, handgrip and number of exacerbations per year predicted the total CGA score. All of the CGA impairment categories related to all domains of the SGRQ (p&lt;0.001). <h3>Conclusion</h3> The CGA, a measure of impairment and frailty, was greater in patients with COPD than comparators. The CGA related to physical function (handgrip, TUG, 6MWD) and QoL independent of age in patients. The use of the prognostic utility of the CGA in COPD is worthy of further study which will be addressed longitudinally by the ARCADE study. *(Funded by GlaxoSmithKline)
Bans and labelling helped to reduce Americans' trans fat levels by 58%
Authors: O. Dyer
Journal: BMJ (2012)

Concentrations of trans fats in the blood of US citizens have plummeted in the past decade as local bans and a national labelling requirement have largely driven the unhealthy ingredient from food in restaurants and on supermarket shelves, shows a study.

Researchers from the Centers for Disease Control and Prevention measured fasting blood samples of white Americans taken in 2000 and 2009 as part of the national health and nutrition examination survey. They found that average combined concentrations of the four major trans fatty acids fell from 93.1 micromol/L (95% confidence interval 82.5 to 103.6) to …
Low Thyroid Hormones and Respiratory-Distress Syndrome of the Newborn
Authors: Raul A. Cuestas, Arnold Lindall, Rolf R. Engel
Journal: New England Journal of Medicine (1976)

To investigate the relation between thyroid function and respiratory-distress syndrome we determined thyroid hormone in cord serum from 39 term and 120 premature newborns. In groups matched for gestational age (33 to 37 weeks) and body length, after exclusion of newborns with birth asphyxia, maternal diabetes and delivery by cesarean section, the newborns with respiratory distress syndrome had significantly lower cord tri-iodothyronine index, higher ratio of thyroxine to tri-iodothyronine and higher thyrotropin concentration than those without syndrome (P less than 0.05 or less). Conversely, the frequency and severity of respiratory-distress syndrome were higher in newborns who had low cord tri-iodothyronine and thyroxine concentration, low free tri-iodothyronine index and high thyrotropin levels. These observations show an association between low thyroid activity at birth and respiratory-distress syndrome and are in accord with animal studies showing accelerated lung maturation due to thyroxine administration.
Comparison of an elemental and polymeric enteral diet in patients with normal gastrointestinal function.
Authors: B J Jones, R Lees, J Andrews, P Frost, D B Silk
Journal: Gut (1983)

In a prospective controlled clinical trial, 70 patients with normal gastrointestinal function were randomised to receive either an elemental diet based on Vivonex HN or an isonitrogenous isocalorie polymeric diet based on Clinifeed 400, administered by continuous 24 hour nasogastric infusion. The two groups of patients were well matched for age, sex, diagnosis, prior starvation, duration of feeding, initial nutritional status, and metabolic status. Nitrogen losses were significantly less on the polymeric feed, despite similar intakes. Serum transferrin rose significantly (1.85 +/- 0.2 to 2.30 +/- 0.2 g/l, p less than 0.05) only in the Clinifeed group, but nutritional parameters were otherwise maintained in both groups. The incidence of diarrhoea (Vivonex, 23.5%; Clinifeed, 30.6%) was not significantly different and was attributable to antibiotics in most cases. Hypokalaemia, which occurred in nearly half the patients, was equally distributed in the two groups, but hypophosphataemia occurred more often in the Vivonex group (p less than 0.05). Liver enzyme disturbances were similar in both groups. The present findings, therefore, provide no evidence that chemically defined 9elemental9 diets containing free amino acids as their nitrogen source are in any way superior to polymeric diets containing whole protein and fat when administered to patients with normal gastrointestinal function.
Immunohistochemical examination of lichen nitidus suggests that it is not a localized papular variant of lichen planus
Authors: Bruce R. Smoller, Timothy C. Flynn
Journal: Journal of the American Academy of Dermatology (1992)

Background: Lichen nitidus is believed, by some, to be a variant of lichen planus, and by others to be a distinct entity. Objective: We examined five cases of lichen nitidus with immunohistochemical reagents designed to characterize the dermal inflammatory infiltrate in an attempt to resolve the uncertainty. Methods: We stained formalin-fixed, paraffin-embedded tissue sections with the following antibodies: L26, A6, KP1, BerH2, OPD4, and HECA-452. Results: The inflammatory infiltrate was 90% A6+, with few L26+ cells. In contrast to lichen planus, KP1+ macrophages were seen and fewer of the lymphocytes demonstrated HECA452. Fifty percent to 80% of lymphocytes were OPD4 positive, similar to that usually seen in lichen planus. Rare Ki-1+ cells were seen in one case. Conclusion: We believe that the pattern of a mixed cellular infiltrate characterized by macrophages and a helper T cell response with few HECA-452+ cells is somewhat different from the pattern seen in lichen planus, wherein almost all of the cells are CD4+HECA-452+ lymphocytes. This suggests a different immunologic pathogenesis. Background: Lichen nitidus is believed, by some, to be a variant of lichen planus, and by others to be a distinct entity. Objective: We examined five cases of lichen nitidus with immunohistochemical reagents designed to characterize the dermal inflammatory infiltrate in an attempt to resolve the uncertainty. Methods: We stained formalin-fixed, paraffin-embedded tissue sections with the following antibodies: L26, A6, KP1, BerH2, OPD4, and HECA-452. Results: The inflammatory infiltrate was 90% A6+, with few L26+ cells. In contrast to lichen planus, KP1+ macrophages were seen and fewer of the lymphocytes demonstrated HECA452. Fifty percent to 80% of lymphocytes were OPD4 positive, similar to that usually seen in lichen planus. Rare Ki-1+ cells were seen in one case. Conclusion: We believe that the pattern of a mixed cellular infiltrate characterized by macrophages and a helper T cell response with few HECA-452+ cells is somewhat different from the pattern seen in lichen planus, wherein almost all of the cells are CD4+HECA-452+ lymphocytes. This suggests a different immunologic pathogenesis.
Halothane-Ether-Air Anesthesia
Authors: Ross Markello, Benton D. King
Journal: JAMA (1964)

Thirty patients were anesthetized with halothane, ether, and air, then maintained on ether and air only. Calibrated draw-over vaporizers, self-inflatable bag, nonrebreathing valve, and mask were used. Arterial blood studies demonstrated that during spontaneous respiration, whole blood pH, arterial carbon dioxide tension (Paco<sub>2</sub>), and arterial oxygen tension (Pao<sub>2</sub>) were well maintained within normal limits. In patients premedicated with meperidine hydrochloride, Pao<sub>2</sub>values tended to be lower than in patients receiving no premedication, although oxygen saturation was 90% or greater in most instances. The sequence of halothane-ether-air combined the safety of ether in maintaining adequate pulmonary ventilation and arterial blood pressure with the convenience of halothane in producing rapid induction with minimal excitement and a lower incidence of postanesthesia vomiting. This technique is suitable for use by relatively unskilled anesthetists in situations where anesthetic gases such as nitrous oxide and oxygen would not be available, as in military mobile surgical units, civilian disasters, and underdeveloped nations.
Flock Worker's Lung
Authors: William W. Merrill
Journal: Annals of Internal Medicine (1999)

Letters6 April 1999Flock Worker's LungWilliam W. Merrill, MDWilliam W. Merrill, MDTulane University School of Medicine; New Orleans Veterans Affairs Medical Center; New Orleans, LA 70112 (Merrill)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-7-199904060-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Reports of new health problems related to occupational exposure are usually controversial. The reports, however well-intended, have two troublesome qualities. They describe something novel, and they cast a broad net, making careful interpretation difficult. Furthermore, they attack the livelihood of workers and employers. The tendency to “shoot the messenger” is, perhaps, understandable.Kern and colleagues' paper on flock worker's lung (1) is no exception. These authors were liberal in their definition of a case. Thus, the material described has a random quality. Cases with eosinophilic lavage cell reactions were lumped with those that had lymphocyte predominance. Almost ...References1. Kern DG, Crausman RS, Durand KT, Nayer A, Kuhn C. Flock worker's lung: chronic interstitial lung disease in the nylon flocking industry. Ann Intern Med. 1998;129:261-72. LinkGoogle Scholar2. Merrill WW. Hypersensitivity pneumonitis. In: Textbook of Internal Medicine, 3d ed. Kelley WN, ed. Philadelphia: JB Lippincott; 1997. Google Scholar Author, Article, and Disclosure InformationAffiliations: Tulane University School of Medicine; New Orleans Veterans Affairs Medical Center; New Orleans, LA 70112 (Merrill) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFlock Worker's Lung: Chronic Interstitial Lung Disease in the Nylon Flocking Industry David G. Kern , Robert S. Crausman , Kate T.H. Durand , Ali Nayer , and Charles Kuhn III Use of Hormone Replacement Therapy by Postmenopausal Women in the United States Nancy L. Keating , Paul D. Cleary , Alice S. Rossi , Alan M. Zaslavsky , and John Z. Ayanian Medical Uncertainty and Practice Variation Jack Beaird Metrics Cited BySynthesis and anti-microbial activity of pyrazolylbisindoles—Promising anti-fungal compoundsChronic Airway Disease Due to Occupational ExposureAmberlyst 15 catalyzed synthesis of indole–pyrazole based tri(hetero)arylmethanes 6 April 1999Volume 130, Issue 7Page: 615KeywordsAntigensHypersensitivityLungsLymphocytes Issue Published: 6 April 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...