tbuckley/cabot-search huggingface dataset:
Circumstances of death in adult sickle cell disease patients
Authors: Deepika S. Darbari, Paul Kple-Faget, John Kwagyan, Sohail Rana, Victor R. Gordeuk, Oswaldo Castro
Journal: American Journal of Hematology (2006)

The purpose of the study was to analyze clinical and/or autopsy findings at the time of death among adults with sickle cell disease (SCD) at Howard University in Washington, DC over a 25-year period. A single physician recorded circumstances of death among 141 adult SCD patients he treated and knew well from 1976 to 2001. These findings were determined by autopsy report and/or clinical assessment. In a subset of 31 patients, autopsy records were reviewed for reports of iron deposition in liver and heart and of organ pathology. One hundred and fourteen (80.9%) of the patients had SS phenotype and 66 (46.8%) were female. The mean ± SD age at death was 36 ± 11 years. Leading circumstances of death included pulmonary hypertension (PHT) (26.2%), sudden death (23.4%), renal failure (22.6%), infection (18.4%), thromboembolism (14.9%), cardiac diagnoses (12.0%), cirrhosis (11.3%), pneumonia or acute chest syndrome (9.9%), bleeding (7.8%), and iron overload (7.0%). When circumstances of deaths that occurred after 1991 (n = 69) were compared to those that occurred in 1991 or earlier (n = 72), PHT (36.2% vs. 16.6%; P < 0.01) was significantly more common in 1992 or later. Significant associations were found between PHT and thromboembolism and between cirrhosis and iron overload. In this proportional mortality study of adults with SCD, PHT was the leading finding at the time of death. Thromboembolism was associated with PHT, and iron overload was associated with cirrhosis. Am. J. Hematol., 2006. © 2006 Wiley-Liss, Inc.
Cerebral Aneurysm Rupture With Survival
Authors: G. B. LEMMON
Journal: JAMA (1967)

ABSTRACT To the Editor:— Pertaining to subarachnoid hemorrhage during anticoagulant therapy with survival, as reported by Finney and Gholston (200:1127, 1967), I wish to report another such case, apparently the second in the literature.In 1964 my patient, a 65-year-old man, was being treated with phenindione (Hedulin) because of myocardial infractions, with prothrombin times consistently about twice normal, when an occipital headache developed. It became increasingly severe over nine days, and on June 22 he lost consciousness, regaining consciousness only on July 4. The spinal fluid was grossly bloody. Arteriograms did not demonstrate the aneurysm. He made a complete and uneventful recovery and has remained fairly well except for angina on rather light effort.
Familial primary gastric lymphoma.
Authors: D Hayoz, M Extermann, B F Odermatt, P Pugin, C Regamey, H Knecht
Journal: Gut (1993)

Familial lymphoma is uncommon and is usually associated with various forms of hereditary immunodeficiencies. Primary gastric lymphomas that occurred in three adults from the same family, who had no overt immunodeficiency or cancer of non-lymphomatous origin, are reported. Two sisters presented with a low grade lymphoma of the mucosa associated lymphoid tissue type. Their father presented with a high grade form of later onset. All lymphomas have been phenotypically characterised as being of B cell origin. Epstein-Bar virus DNA was detected by polymerase chain reaction in the biopsy specimen of the high grade lymphoma but bcl-2/JH protooncogene rearrangement, t (14:18), was not identified in either the low or high grade lymphoma specimens tested.
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
Authors: Sandra Gardam, Vivian M. Turner, Holly Anderton, Sandhya Limaye, Antony Basten, Frank Koentgen, David L. Vaux, John Silke, Robert Brink
Journal: Blood (2011)
Childhood Abuse and Diabetes in the Community
Authors: Renee D. Goodwin, Stuart P. Weisberg
Journal: Diabetes Care (2002)

Diabetes is a significant pubic health problem among children and adolescents, and its prevalence has rapidly increased in recent years (1). There is some evidence to suggest that chronic stress is associated with onset of physical illness, such as diabetes (2). Childhood abuse is thought to be one source of severe, persistent stress. Preclinical data suggest that stress is associated with onset of diabetes (3). No previous study has investigated this hypothesis …
Prescribing Hypnotic and Anti-Anxiety Drugs
Authors: ROBERT F. MARONDE
Journal: Annals of Internal Medicine (1973)

Letters1 September 1973Prescribing Hypnotic and Anti-Anxiety DrugsROBERT F. MARONDE, M.D., MILTON SILVERMAN, PH.D.ROBERT F. MARONDE, M.D.Search for more papers by this author, MILTON SILVERMAN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-3-452 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Computerized prescription processing in a large hospital outpatient service has enabled us to analyze various aspects of drug use, including physician prescribing habits (1-3). In previous reports, covering only relatively brief periods, we have noted that some patients receive what seem to be grossly excessive amounts of drugs with abuse potential.In this study we focused on the prescribing and dispensing of selected anti-anxiety and hypnotic drugs—all having significant potential for abuse (4)—during 12 months. These include diazepam, chlordiazepoxide, meprobamate, secobarbital, and pentobarbital. Together, they represented 14.4% of all outpatient prescriptions dispensed during the year.For this...References1. MARONDELEEMCCARRON RPM: A study of prescribing patterns. Med Care 5:383-395, 1971 CrossrefGoogle Scholar2. MARONDESEIBERTKATZOFF RSJ: Prescription data processing—its role in the control of drug abuse. Calif Med 117:22-28, September 1972 MedlineGoogle Scholar3. MARONDE R: Drug Utilization Review with On-Line Computer Capability. Selected Methodology and Fndings From a Demonstration. SSA/ORS Staff Paper No. 13, DHEW Publication Number (SSA) 73-11853. Washington, D.C., Superintendent of Documents, 1973 Google Scholar4. LENNARDEPSTEIN HL: Mystification and Drug Misuse: Hazards in Using Psychoactive Agents. Jossey-Bass, San Francisco, 1971 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Pharmacy and Health Policy Program School of Medicine University of California San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAbuse liability and the regulatory control of therapeutic drugs: untested assumptionsIncreased Prescribing of Valium, Librium, and other Drugs—An Example of the Influence of Economic and Social Factors on the Practice of MedicineIs the Use of Hypnotics, Sedatives and Minor Tranquillizers Really a Major Health Problem?Drug Use as Determined by Interviews 1 September 1973Volume 79, Issue 3Page: 452-453KeywordsAnxiolyticsComputersDiazepamDrug abuseDrugsHabitsOutpatient clinicsOutpatients Issue Published: 1 September 1973 PDF DownloadLoading ...
RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S35) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS
Authors: Dominic D. Dziewiatkowski
Journal: The Journal of Experimental Medicine (1952)

Fifteen minutes after intraperitoneal injection of sulfur-35 as sodium sulfate to 7-day-old rats the concentration of the isotope was highest in the cartilage at the epiphyseal-diaphyseal junction of long bones but was demonstrable throughout the entire epiphysis. Up to the 24th hour the pattern of deposition did not change as the concentration continued to increase. As centers of secondary ossification developed, there occurred in them an increased concentration of some form of sulfur, insoluble as the barium salt. This sulfur was probably derived from the cartilage which the center of secondary ossification replaced. Up to about the 30th minute after injection the sulfur-35 was deposited transitorily in a high concentration in discrete loci of the bone marrow. Excluding this transitory deposition, the highest concentration of the radioisotope in the bone marrow was seen in the specimens removed 24 hours after administration. In the bone shaft the sulfur-35, in a form which was insoluble in an alkaline solution of barium ions, was deposited diffusely up to the 24th hour after its administration. Thereafter, the radioisotope decreased in concentration in the middle portion of the bone shaft. However, the concentration of a similarly characterized sulfur-35-bearing component in the ends of the diaphysis continued to increase up to at least the 96th hour after injection.
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
Authors: Mateusz Koptyra, Rafal Falinski, Michal O. Nowicki, Tomasz Stoklosa, Ireneusz Majsterek, Margaret Nieborowska-Skorska, Janusz Blasiak, Tomasz Skorski
Journal: Blood (2006)
Consultants don't cry
Authors: C Douglas
Journal: BMJ (1994)

If you have three quarters of an hour to spare and happen to be in the right place at the right time, there are few gatherings to match a decent medical funeral. In a teaching centre like ours they provide unpredictable but nonetheless welcom reunions that allow sentiment, a certain amount of communal pride, and - not incidentally - a chance to agree that old Joe had his rough side/cross to bear/undoubted shortcomings, but nevertheless did a great deal/a fair bit/as much as could have been expected, for Edinburgh medicine in general and for his own specialty in particular.

We sing a hymn or two quite passably, hear a little more than we …
LARYNGECTOMY FOR CANCER.
Authors: H. H. GERMAIN
Journal: JAMA (1904)

Previous to 1888 the death rate for laryngectomy was very high. According to Sendziak,<sup>1</sup>who has collected the largest number of cases, the mortality is 35 per cent. for all cases up to 1897. If we now look at the cases operated on from 1888 to 1898, we find that the death rate has fallen to 14.5 per cent., with a corresponding fall in the number of recurrences—11.2 per cent. as compared with 30.3 per cent. This marked improvement ha [ill] due to the new methods which aim to avoid sepsis and to do away with aspiration pneumonia. These two conditions have been responsible for the majority of the fatal cases, while reflex inhibition of the heart through the superior laryngeal nerve and death from vagus degeneration deserves mention. Recurrence is less frequent because of early and more radical operating with regard for the lymphatics. The first step in advance
Laser Surgery-Reply
Authors: V. A. Fasano
Journal: JAMA (1984)

<h3>In Reply.—</h3> The surgical treatment of AVMs with the traditional technique consists in the identification, isolation, and coagulation of the feeding arteries to interrupt the flow to the malformation; the nidus is then removed with reduced blood loss. The feeding arteries are located subcortically and usually in depth, requiring for this reason a deeper dissection in the healthy tissue. Since they always supply blood circulation to normal tissue, only the shunting arterioles arising from the feeding channels should be interrupted.<sup>1</sup> The main difference between traditional technique and laser technique consists essentially in the possibility to act directly on the pathological vessels of the nidus, inducing an immediate constriction by shrinkage or progressive thrombosis by endothelial damage<sup>2,3</sup>with reduced hemorrhages. Even if not directly irradiated, because of the small size of the vessels, thrombosis propagates from the coagulated nidus into the shunting arterioles, which can be obliterated without any
Spectrum of MHC Class II Variability in Darwin's Finches and Their Close Relatives
Authors: A. Sato, H. Tichy, P. R. Grant, B. R. Grant, T. Sato, C. O'hUigin
Journal: Molecular Biology and Evolution (2011)

The study describes .400major histocompatibility complex (MHC) class II B exon 2 and 114 intron 2 sequences of 36 passerine bird species, 13 of which belong to the group of Darwin's finches (DFs) and the remaining 23 to close or more distant relatives of DFs in Central and South America.The data set is analyzed by a combination of judiciously selected statistical methods.The analysis reveals that reliable information concerning MHC organization, including the assignment of sequences to loci, and evolution, as well as the process of species divergence, can be obtained in the absence of genomic sequence data, if the analysis is taken several steps beyond the standard phylogenetic tree construction approach.The main findings of the present study are these: The MHC class II B region of the passerine birds is as elaborate in its organization, divergence, and genetic diversity as the MHC of the eutherian mammals, specifically the primates.Hence, the reported simplicity of the fowl MHC is an oddity.With the help of appropriate markers, the divergence of the MHC genes can be traced deep in the phylogeny of the bird taxa.Transspecies polymorphism is rampant at many of the bird MHC loci.In this respect, the DFs behave as if they were a single, genetically undifferentiated population.There is thus far no indication of alleles that could be considered species, genus, or even DF group specific.The implication of these findings is that DFs are in the midst of adaptive radiations, in which morphological differentiation into species is running ahead of genetic differentiation in genetic systems such as the MHC or the mitochondrial DNA.The radiations are so young that there has not been enough time to sort out polymorphisms at most of the loci among the morphologically differentiating species.These findings parallel those on Lake Victoria haplochromine fishes.Several of the DF MHC allelic lineages can be traced back to the MHC genes of the species Tiaris obscura, which we identified previously as the closest extant relative of DFs in continental America.
Randomized, placebo-controlled, double-blind study on clinical efficacy of ciclopiroxolamine 1% cream in facial seborrhoeic dermatitis
Authors: P. Dupuy, C. Maurette, J.C. Amoric, O. Chosidow
Journal: British Journal of Dermatology (2001)

Journal Article Randomized, placebo‐controlled, double‐blind study on clinical efficacy of ciclopiroxolamine 1% cream in facial seborrhoeic dermatitis Get access P. Dupuy, P. Dupuy Pierre‐Fabre Research Institute, Allée Camille Soula, BP 74, Vigoulet, 31322 Castanet Tolosan Cedex, France *Pierre‐Fabre Dermatology, Castres, France †Department of Internal Medicine, Pitié Salpétrière Hospital, Paris, France P.Dupuy. E‐mail: patrick.dupuy@pierre‐fabre.com Search for other works by this author on: Oxford Academic Google Scholar C. Maurette, C. Maurette Pierre‐Fabre Research Institute, Allée Camille Soula, BP 74, Vigoulet, 31322 Castanet Tolosan Cedex, France *Pierre‐Fabre Dermatology, Castres, France †Department of Internal Medicine, Pitié Salpétrière Hospital, Paris, France Search for other works by this author on: Oxford Academic Google Scholar J.C. Amoric, J.C. Amoric Pierre‐Fabre Research Institute, Allée Camille Soula, BP 74, Vigoulet, 31322 Castanet Tolosan Cedex, France *Pierre‐Fabre Dermatology, Castres, France †Department of Internal Medicine, Pitié Salpétrière Hospital, Paris, France Search for other works by this author on: Oxford Academic Google Scholar O. Chosidow, O. Chosidow Pierre‐Fabre Research Institute, Allée Camille Soula, BP 74, Vigoulet, 31322 Castanet Tolosan Cedex, France *Pierre‐Fabre Dermatology, Castres, France †Department of Internal Medicine, Pitié Salpétrière Hospital, Paris, France Search for other works by this author on: Oxford Academic Google Scholar THE STUDY INVESTIGATOR GROUP THE STUDY INVESTIGATOR GROUP Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 5, 1 May 2001, Pages 1033–1037, https://doi.org/10.1046/j.1365-2133.2001.04194.x Published: 01 May 2001
Spatial and temporal linking of epicardial activation directions during ventricular fibrillation in dogs. Evidence for underlying organization.
Authors: R S Damle, N M Kanaan, N S Robinson, Y Z Ge, J J Goldberger, A H Kadish
Journal: Circulation (1992)

BACKGROUND It remains controversial as to whether electrical activation during ventricular fibrillation (VF) is organized. To detect the presence of organization in VF, the direction of epicardial activation (EA) at multiple sites was examined by using vector mapping. If VF is not a random process, EA direction at a given site should be related to adjacent sites and prior beats. METHODS AND RESULTS Thirteen dogs with healing myocardial infarction (MI) and four dogs without MI had VF induced by programmed stimulation. Using a plaque electrode array with a 2.5-mm interelectrode distance, 91 vector loops were created for each "beat" of VF. Direction of maximum EA was determined at each site for the first 10 consecutive beats of VF and for 10 consecutive beats recorded 5 seconds after VF was established. Spatial and temporal linking of EA directions was evaluated by the ability of activation direction at a given site to be predicted by activation directions at eight adjacent sites for the index beat and at eight adjacent sites and the site of interest for the preceding beat using stepwise linear regression. The strength of the model as reflected by the correlation coefficient (r) indicated the degree of linking. We determined 1) changes in the degree of linking over time during a given episode of VF (using a paired-difference t test), 2) differences in the degree of linking between the anterior and posterolateral walls in animals with (n = 4) and without (n = 4) MI (using two-way ANOVA), and 3) the effect of repeated inductions (n = 10) on the degree of linking (using one-way ANOVA with repeated measures). During 57 episodes of VF, r for each model ranged from 0.64 to 0.88 during the transition to VF to 0.39-0.78 during established VF (p &lt; 0.0001 for the difference). The presence of MI, the site of recording, and repeated inductions did not affect the degree of linking. For each episode, spatial linking was more prominent than temporal linking. CONCLUSIONS Electrical activation during VF is organized. The degree of linking of EA directions during VF is not affected by the presence of MI, the site of recording, or repeated inductions of VF. During the first 5 seconds of VF, the degree of linking decreases.
Calculate the carbon footprint of your hospital
Authors: P. Grant, S. L. Bailey
Journal: BMJ (2010)

The NHS is a big polluter, and this shouldn’t be forgotten however the priority of environmental issues in the public services fluctuates. Calculating the carbon footprint of your organisation is relatively straightforward, and the Carbon Trust has produced an online calculator to enable you to do so (www.carbontrust.co.uk/cut-carbon-reduce-costs/calculate/carbon-footprinting/Pages/carbon-footprinting.aspx).

You need to gather the following information, which should be readily accessible (the …
Trends in US Medical School Faculty Salaries, 1988-1989 to 1998-1999
Authors: Erich Studer-Ellis
Journal: JAMA (2000)

Expansion of managed care, intensified price competition, and the introduction of the Medicare Fee Schedule have all affected physician compensation during the past decade. We examine trends in the salaries of medical school faculty, particularly MD clinical faculty, based on a more extensive salary database than has been used previously. Data collected through the Association of American Medical Colleges' Faculty Salary Survey for the academic years 1988-1989, 1993-1994, and 1998-1999 were analyzed, and inflation-adjusted salary growth rates for clinical and basic science faculty during two 5-year periods, 1988-1993 and 1993-1998, compared across faculty ranks, departments, and various school characteristics. The comparison showed that, between 1988 and 1998, the actual median clinical faculty salary increased from $101,000 to $150,000, and the actual median basic science faculty salary increased from $52,000 to $78,000. Bivariate and multivariate analyses showed that the proportionate change in real mean salary (base year, 1988) in each 5-year period was related to department and faculty rank for clinical faculty (P<.001) and faculty rank for basic science faculty (P<.001). The inflation-adjusted annualized compound growth rate of clinical faculty salaries declined from 1.9% per year (1988-1993) to 0.2% per year (1993-1998), while the growth rate of basic science faculty salaries increased from 0.3% per year (1988-1993) to 1.3% per year (1993-1998). From 1993 to 1998, inflation-adjusted annualized salary growth rates in several clinical departments were negative (anesthesiology, -1.1%; obstetrics and gynecology, -0.5%; radiology, -0.4%; and neurology, -0.1%) but were positive for family practice (+2.7%). Significant differences in salary growth related to school characteristics (eg, geographic region, public vs private, community based vs non-community based, and research intensity) were specific to particular study periods. Overall, while actual average medical school faculty salaries are increasing, the real growth rate of average clinical faculty salaries is declining and that of basic science faculty increasing. JAMA. 2000;284:1130-1135
EXPERIMENTAL ACUTE NEPHRITIS
Authors: Kingo Goto
Journal: The Journal of Experimental Medicine (1918)

1. In experimental nephritis caused by cantharidin, arsenic, diphtheria toxin, and potassium chromate, in addition to the retention of the non-protein and urea nitrogen and of the chlorides in blood, an acidosis occurs. 2. Sodium bicarbonate given by the stomach has the power of diminishing the acidosis in these types of nephritis. 3. The degree of increase in the non-protein and urea nitrogen content in the blood in mild nephritis varies considerably in different dogs receiving the same dose per kilo of a given poison. 4. Histological examination shows little if any influence resulting from the administration of sodium bicarbonate upon the grade of the nephritis induced by the poisons.