tbuckley/cabot-search huggingface dataset:
MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program
Authors: Shimin Hu, Zijun Y. Xu-Monette, Alexander Tzankov, Tina Green, Lin Wu, Aarthi Balasubramanyam, Wei-min Liu, Carlo Visco, Yong Li, Roberto N. Miranda, Santiago Montes-Moreno, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W. L. Choi, Xiaoying Zhao, J. Han van Krieken, Qin Huang, Jooryung Huh, Weiyun Ai, Maurilio Ponzoni, Andrés J. M. Ferreri, Fan Zhou, Graham W. Slack, Randy D. Gascoyne, Meifeng Tu, Daina Variakojis, Weina Chen, Ronald S. Go, Miguel A. Piris, Michael B. Møller, L. Jeffrey Medeiros, Ken H. Young
Journal: Blood (2013)
FURTHER OBSERVATIONS ON THE CULTIVATION OF VACCINE VIRUS IN LIFELESS MEDIA
Authors: Thomas M. Rivers, S. M. Ward
Journal: The Journal of Experimental Medicine (1933)

We have made ten attempts to cultivate vaccine virus in tissue extracts prepared according to the method described by Eagles and Kordi (4). Renal, testicular, and chick embryo extracts were employed with a dermal strain of vaccine virus and with the Levaditi strain of neuro-vaccine virus. In no instance were we able to show that the virus multiplied in the extract media. Both of these strains of virus, however, multiplied in media containing bits of minced viable tissue. Furthermore, treatment of rabbit testicular tissue and chick embryo tissue in the manner described by Eagles and Kordi for the preparation of the extracts leaves some cells not only alive but capable of proliferation. Although the results of our work are not in accord with those obtained by Eagles and Kordi, we offer no explanation for the discrepancy. Nevertheless, one cannot examine the results of our work recorded in the six tables without recognizing the fact that in the types of media used the presence of viable cells appears to be essential for the multiplication of vaccine virus. Rabbit testicular tissue and bits of chick embryos support the regeneration of the active agent more efficiently than does rabbit renal tissue.
SOME GENERAL CONSIDERATIONS IN RELATION TO THE NATURE AND TREATMENT OF DISEASE.
Authors: LOUIS BALMAT BAKER
Journal: JAMA (1896)

"Flower in the crannied wall, I pluck you out of the crannies; Hold you here, root and all, in my hand, Little flower—but if I could understand What you are, root and all, and all in all, I should know what God and man is." How profoundly true this is! Given one fact and you have the key to the universe, a formula that can solve all problems, a talisman that will open all the arcana of nature. Be faithful to your one fact and it becomes an unfailing test for truth, for nothing that contradicts it, can be true. An isolated fact is an impossibility. Conditions that are unvarying and know no shadow of turning, relate your one fact to all the other facts in nature. And these laws and relations are constant; the same yesterday, to-day and forever. To believe that nature is fickle and capricious, doing a
What is Social Medicine?
Authors: W. Hobson
Journal: BMJ (1949)

INFANTILE DIARRHOEA AND VOMITINGDlINSRNH 125diarrhoea and vomiting and two healthy.The significance of these related strains of Bact. coli cannot as yet be assessed, but further work may bring an answer to this problem.Another and more important problem is the possible status of Bact. coli D 433, when confirmed by biochemical and serological test, as a causative agent of infective diar- rhoea and vomiting.Its close association with clinical cases in certain outbreaks of diarrhoea and vomiting and its absence from control groups of babies suggest that it may play some part in the genesis of the disease, but further work is necessary before any definite conclusion can be reached.Possible lines of research are animal transmis- sion experiments, pathogenicity and toxicity tests, labora- tory investigation of the strain for further distinguishing characteristics, closer correlation between the clinical find- ings and the detection of the strain, and studies of possible dual virus and Bact. coli causation. SummaryA clinical and bacteriological investigation of infantile diar- rhoea and vomiting was carried out.The clinical material was drawn from one outbreak of epidemic diarrhoea of the new- born (Group A), two outbreaks of diarrhoea and vomiting in a mothers and babies' hostel (Groups B and C), one outbreak in a residential nursery (Group D), intercurrent cases among sick babies in hospital (Group E), two series of admissions to gastro-enteritis units (Groups F and G), and endemic diarrhoea and vomiting in a residential nursery (Group H).No recognized intestinal pathogen was isolated, and virus investigation of fatal cases yielded negative results.Bact. coli sera, prepared from strains isolated from cases of Group A, led to the identification of a particular serological type, referred to as Bact. coli D 433.It was isolated from all nine cases examined during life in this outbreak.The same sera were subsequently used for the identification of Bact. coli D 433 among the other groups of babies studied.It was isolated from all 22 cases (100%) of Groups B, C, and D, from 21 (91 %) of the 23 cases in Group E, from 6 (43%) of the 14 cases in Group F, from only 5 (21 %) of the 24 cases in Group G, and from none of the 14 cases in Group H.Bact. coli D 433 was not isolated from any of the 208 babies
High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons
Authors: Katrina Y. Choe, Su Y. Han, Perrine Gaub, Brent Shell, Daniel L. Voisin, Blayne A. Knapp, Philip A. Barker, Colin H. Brown, J. Thomas Cunningham, Charles W. Bourque
Journal: Neuron (2015)

The mechanisms by which dietary salt promotes hypertension are unknown. Previous work established that plasma [Na+] and osmolality rise in proportion with salt intake and thus promote release of vasopressin (VP) from the neurohypophysis. Although high levels of circulating VP can increase blood pressure, this effect is normally prevented by a potent GABAergic inhibition of VP neurons by aortic baroreceptors. Here we show that chronic high salt intake impairs baroreceptor inhibition of rat VP neurons through a brain-derived neurotrophic factor (BDNF)-dependent activation of TrkB receptors and downregulation of KCC2 expression, which prevents inhibitory GABAergic signaling. We show that high salt intake increases the spontaneous firing rate of VP neurons in vivo and that circulating VP contributes significantly to the elevation of arterial pressure under these conditions. These results provide the first demonstration that dietary salt can affect blood pressure through neurotrophin-induced plasticity in a central homeostatic circuit.
Treatment of Severe Reflux Esophagitis with Cimetidine and Metoclopramide
Authors: David A. Lieberman, Emmet B. Keeffe
Journal: Annals of Internal Medicine (1986)

Reflux esophagitis may be unresponsive to standard medical therapy with an H2-receptor antagonist drug. Twenty-five patients with chronic reflux esophagitis, refractory to cimetidine treatment alone, were randomly assigned in a double-blind design to receive cimetidine (1200 mg/d), in combination with metoclopramide (40 mg/d) or placebo. Nine of twelve patients receiving cimetidine with metoclopramide had significant symptomatic improvement at the end of the 8-week study period, compared with 3 of 12 patients receiving cimetidine with placebo (p less than 0.02). Endoscopic appearance improved in 9 patients receiving metoclopramide and in 4 patients receiving placebo (p less than 0.05). Neither group had significant improvement in lower esophageal sphincter pressure, 24-hour esophageal pH recordings, and esophageal histologic findings. Side effects were common with cimetidine and metoclopramide but were rarely disabling. This combination is efficacious in the management of chronic reflux esophagitis but, because of frequent side effects, should be reserved for patients refractory to treatment with cimetidine alone.
NEW METHOD OF INFLATING (CATHETERIZING) THE MIDDLE EAR.
Authors: J. M. BALL
Journal: JAMA (1891)

The great importance of diseases of the middle ear, the serious and sometimes fatal consequences attending this class of cases, and the difficulty in applying therapeutic aid to an organ so deeply situated, are facts which are recognized by all enlightened medical men at the present day. In the therapeusis, as well as the diagnosis, of inflammations of the tympanic chamber, inflation occupies a prominent position. By inflation is meant the process by which air is driven through the Eustachian tube into the tympanum. There are various methods of accomplishing this result. Before proceeding further, I would ask your attention to a few historical facts. HISTORY OF MIDDLE EAR INFLATION. The Eustachian tube was first accurately described by Bartholomew Eustachius, professor of anatomy at Rome. He died in 1574, leaving posterity a series of splendid copperplate engravings designed to illustrate the anatomy of the human body. These were his own
Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype
Authors: Kazuhiko Takahashi, Hiroaki Suwa, Tomoo Ishikawa, Hidehito Kotani
Journal: Journal of Clinical Investigation (2002)

Histamine is an aminergic neurotransmitter that is localized in the CNS and in peripheral tissues. To date, four histamine receptors have been identified, and the H3 receptor, which was recently cloned, is predominantly expressed in the CNS. The peripheral functions of histamine have been investigated intensively using available molecular and pharmacological tools, and the molecular identification of the H3 receptor opens up new possibilities for investigating the role of histamine in central tissues. To understand the biological function of the histamine presynaptic autoreceptor H3, we inactivated the receptor through homologous recombination. H3(-/-) mice manifest mild obese phenotypes that are characterized by increases in body weight, food intake, and adiposity and by reductions in energy expenditure. Consistent with these observations, homozygous null mice have insulin and leptin resistance, increased levels of plasma leptin and insulin, and decreased levels of histamine in the hypothalamic/thalamic region of their brains coupled with increased histamine turnover. The expression of UCP1 in brown adipose tissue and of UCP3 in brown adipose tissue, white adipose tissue, and skeletal muscle is decreased in H3(-/-) mutants, and the anorexigenic activity of thioperamide is not observed. These results suggest that neuronal histamine is a mediator of body-weight homeostasis and that neuronal histamine functions through H3 receptors in mice.
Mortality in elderly patients admitted for respite care.
Authors: S Howarth, C Clarke, R Bayliss, A G Whitfield, J Semmence, M J Healy
Journal: BMJ (1990)

OBJECTIVE--To determine whether admitting elderly patients to hospital to give temporary relief to their carers is associated with increased mortality. DESIGN--Prospective multicentre study comparing the mortality of patients admitted on a one off or rotational basis with that experienced while they were awaiting admission. SETTING--A wide range of urban and rural district general, geriatric or long stay, and general practitioner hospitals. PATIENTS--474 Patients aged 70 or over who had 601 admissions. MAIN OUTCOME MEASURE--Death. RESULTS--16 (3.4%) Of the 474 patients (2.7% of all 601 admissions) died while in hospital during an average stay of 15.7 days whereas 23 (4.9%) patients died while awaiting admission (average waiting time was 34.2 days). The 16 deaths in hospital and the 23 deaths during the longer waiting period correspond to death rates of 19.9 and 12.5 per 10,000 person days respectively. The difference between these of 7.4 is not statistically significant (95% confidence interval -3.6 to 18.3). The estimated relative risk of dying in hospital is 1.59 but the 95% confidence interval is wide (0.84 to 3.01). CONCLUSION--Although the death rates are slightly higher in those admitted to hospital for relief care than in those awaiting admission, the difference was not significant, and the death rate in both groups was reassuringly small.
Psychosocial Predictors of Cancer and Internal Diseases
Authors: Ronald Grossarth-Maticek
Journal: Psychotherapy and Psychosomatics (1980)

In 1965, questionnaire data were obtained for 1,353 inhabitants of a Yugoslavian town on the following variables: blocked expression of feelings and needs; psychosocial stress in the form of either lasting depression and hopelessness or lasting anger and irritation; harmonization and idealization, with negation of self; rational orientation with repression of emotions; psychopathological symptoms; 'exposive behavior', including exposure to adverse environmental conditions, abuse of medicines etc., ignoring signs of illness, hyperactivity. These variables were related to the incidence of cancer and internal diseases over the next 10 years. A discriminant analysis yielded 93% correct predictions. The results, beyond their theoretical significance, open up substantive possibilities of early recognition as well as preventive and curative sociopsychotherapy of cancer and internal diseases.
Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis
Authors: Daniel J. Cua, Herve Groux, David R. Hinton, Stephen A. Stohlman, Robert L. Coffman
Journal: The Journal of Experimental Medicine (1999)

The effectiveness of interleukin 10 (IL-10) in the treatment of autoimmune-mediated central nervous system inflammation is controversial. Studies of the model system, experimental autoimmune encephalomyelitis (EAE), using various routes, regimens, and delivery methods of IL-10 suggest that these variables may affect its immunoregulatory function. To study the influence of these factors on IL-10 regulation of EAE pathogenesis, we have analyzed transgenic mice expressing human IL-10 (hIL-10) transgene under the control of a class II major histocompatibility complex (MHC) promoter. The hIL-10 transgenic mice are highly resistant to EAE induced by active immunization, and this resistance appears to be mediated by suppression of autoreactive T cell function. Myelin-reactive T helper 1 cells are induced but nonpathogenic in the IL-10 transgenic mice. Antibody depletion confirmed that EAE resistance is dependent on the presence of the transgenic IL-10. Mice expressing the hIL-10 transgene but not the endogenous murine IL-10 gene demonstrated that transgenic IL-10 from MHC class II–expressing cells is sufficient to block induction of EAE. This study demonstrates that IL-10 can prevent EAE completely if present at appropriate levels and times during disease induction.
Pocket Guide to Stress Testing
Authors: John F. Moran
Journal: Annals of Internal Medicine (1998)

Medical Writings1 February 1998Pocket Guide to Stress TestingJohn F. Moran, MDJohn F. Moran, MDLoyola University Medical Center, Maywood, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-3-199802010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Chung EK, Tighe DA. 403 pages. Boston: Blackwell Science; 1997. $32.95 ISBN 0865425094. Order phone 800-759-6102.Field of medicine: CardiologyFormat: Softcover book.Audience: Primary care physicians, internal medicine specialists, and family practice physicians interested in stress testing.Purpose: To describe stress testing so that a physician can perform it.Content: This book, designed to fit into the pocket of a lab coat, is divided into 21 chapters. The initial chapters cover the preparation of the patient and the indications, contraindications, and protocols for electrocardiographic testing. Several chapters describe stress testing done using various imaging techniques. An important chapter discusses ... Author, Article, and Disclosure InformationAffiliations: Loyola University Medical Center, Maywood, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1998Volume 128, Issue 3Page: 251KeywordsBayesian methodDrugsElectrocardiographyExerciseHeartHeart rateImaging techniquesIschemiaPrimary care physicians Issue Published: 1 February 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PTH-102 Preliminary Evidence for a Role of the Renin Angiotensin System in Intestinal Fibrosis in Crohn’S Disease Using Angiotensin Receptor Immunohistochemistry
Authors: S Ray, J Soeda, J Oben, J Sanderson
Journal: Gut (2013)

<h3>Introduction</h3> Fibrosis is a major limitation to successful non-surgical treatment of Crohn’s disease (CD) and is a cause of significant morbidity. The pathophysiological determinants of intestinal fibrosis in CD remain uncertain. The renin-angiotensin system (RAS) plays a critical role in blood pressure control and fluid and electrolyte homeostasis but has recently been implicated in fibrogenesis in multiple organ systems. Angiotensin II is the main active peptide in the RAS and evidence suggests it has important proliferative and profibrogenic roles acting through its AT1 receptor. Pharmacological blockade of the AT1 receptor has become a key element in the management of chronic cardiac and renal disorders and abrogates fibrosis. It also appears anti-fibrotic in chronic liver disease. Subsequent studies suggest that the AT2 receptor may act to oppose many of the proliferative and fibrogenic actions of AT1. Few studies have investigated a role for the RAS in intestinal fibrosis in CD. <h3>Aim</h3> A preliminary study to use immunohistochemistry to determine AT1 and AT2 expression in resected ileum of patients with CD. <h3>Methods</h3> Immunohistochemistry for AT1 and AT2 receptors was performed on archival formalin fixed paraffin embedded ileum of patients who had undergone resection for stricturing CD (n = 6), histologically normal ileum in patients undergoing colectomy for ulcerative colitis (UC) (n = 4) or right hemicolectomy for colon cancer (n = 1). We used commercial antibodies for AT1(SC1173) and AT2(SC9040) and the secondary antibody (Vector ImmPRESS Anti-Rabbit Ig (peroxidase) Polymer Detection Kit) under optimised conditions. <h3>Results</h3> AT1 and AT2 staining patterns differed quite clearly between CD resection samples and those from UC and cancer controls. Control and UC cases showed clear staining of the muscularis for AT1 but consistently negative staining of epithelial or lamina propria compartments, whilst AT2 stained only the epithelial layer. Conversely, each of the 6 CD cases showed clear AT1 staining of the epithelial layer as well as muscularis but negative staining for AT2 in all areas. Occasional myofibroblast-like cells were also specifically stained by AT1. RTPCR analysis of RNA from CCD18CO cells (intestinal myofibroblast cell line) confirmed AT1 expression and no AT2 expression. <h3>Conclusion</h3> These preliminary findings demonstrate a distinct difference in angiotensin receptor expression pattern in CD and non-CD ileum. This suggests a possible alteration in the balance between AT1 and AT2 receptor expression in CD strictures contributing to fibrogenesis and certainly merits further investigation <h3>Disclosure of Interest</h3> None Declared.
Case of Swallowing an Artificial Tooth, with its Plate
Authors: E. Lister
Journal: BMJ (1857)

crania."Mr. B. obtained medical aid, for the first time since the injtury, upon the 3rd of July-eight days afterwards.On July 12th I saw the case in consuiltation: the patient said that the eye felt distended, and that the eyelids seemed to press upon the globe, althoughl neither spasm of the orbicularis muscle nor chemosis of the conjunctiva were present.In the left temple a sense of pressure was experienced, which de- scended to the upper wisdom tooth of the same side; and thence pain of a more acute character spread over the corre- sponding half of the face and head.'rhe scalp was so sore that the sligl0test touch was insupportable.The pains under- went considerable aggravation at night.Mr. B. had hitherto used linen, dipped from time to time in cold water, as a local application to the painful parts, with the effect of inducing, perfect ease so long as the temiiperature of the surface was maintained at a low degree.Darkness was indispensable for the comfort of the eye, which presented, on examination, in- tense conjunctival redniess, and iritis with watery discharge.HISToRY.Nine years before, the patient met with a similar accident fiom the gold solution: it was followed by ophtlialmia, intolerance of light, and hemicrania, for which he used poultices only, andl in a week resumed his avocations.A year and nine months since, he was laid up two months and nine days with acute rheumnatismn, whiclh affected the head, and the joints botl large and small.He got out of doors on the 2nd of December, but was not free from pain.At Christmas the disease again detained him within doors five weeks.It wouldl be foreign to my object to relate t.he treatment I recommended for the ophthalmia; it will suffice to say that, in less than three weeks, the eye was healthy functionally and organically, and the patient able to walk several miles.
Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B–associated thrombocytopenia
Authors: Caterina Casari, Vivian Du, Ya-Ping Wu, Alexandre Kauskot, Philip G. de Groot, Olivier D. Christophe, Cécile V. Denis, Bas de Laat, Peter J. Lenting
Journal: Blood (2013)
Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetes mellitus patients
Authors: Ozen Oz Gul, Ercan Tuncel, Yusuf Yilmaz, Engin Ulukaya, Cuma Bulent Gul, Sinem Kiyici, Arzu Yilmaztepe Oral, Metin Guclu, Canan Ersoy, Sazi Imamoglu
Journal: Metabolism (2009)
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice
Authors: Carmen Guerra, Alberto J. Schuhmacher, Marta Cañamero, Paul J. Grippo, Lena Verdaguer, Lucía Pérez-Gallego, Pierre Dubus, Eric P. Sandgren, Mariano Barbacid
Journal: Cancer Cell (2007)
Pediatric Window-Cord Strangulations-Reply
Authors: Renae Rauchschwalbe, N. Clay Mann
Journal: JAMA (1997)

<h3>In Reply.</h3> —Since documented accident investigations indicate that children become entangled in window cords as well as suspended from looped cords, we agree with Dr Bishai that the ideal environment to reduce pediatric window-cord strangulations is one in which window cords are eliminated. However, even a cordless environment will not eliminate all asphyxia deaths since slat strings also pose a risk (7% of documented strangulations). Voluntary industry conformance to the recently published standard for corded window-covering products goes a long way in correcting many mechanisms of injury in new products. However, the rate of mortality does not appear to be decreasing, partly because public awareness results in increased reporting and because older products remain in many homes. Cutting the loop and adding individual tassels to each cord is an instantly effective, cost-efficient, and easily implemented method of reducing the risk of asphyxia death associated with these window blinds. We also advocate the