tbuckley/cabot-search huggingface dataset:
The First Heart Sound in Complete Heart Block
Authors: GARY W. BURGGRAF, ERNEST CRAIGE
Journal: Circulation (1974)

Eight subjects with complete atrioventricular heart block were studied with simultaneous echocardiography and phonocardiography to investigate the role of the mitral and tricuspid valves in the genesis of the first heart sound (S 1 ). Mitral valve motion was studied in all cases and tricuspid patterns in three. At P-R intervals less than 0.20 sec, mitral leaflet closure was completed by ventricular systole. Below P-R values of 0.20 sec there was an inverse relationship between P-R and S 1 amplitude. With P-R between 0.20 and 0.50 sec atrial systole closed the mitral valve without recordable sound. Beyond P-R intervals of 0.50 sec there was reopening of the mitral valve and secondary closure initiated by ventricular systole which was coincident with S 1 . The extent of mitral leaflet separation at the onset of ventricular systole correlated with S 1 amplitude. Pre-ejection period was not related to S 1 intensity. Over a wide range of P-R intervals in two subjects with a split S 1 , tricuspid valve closure was simultaneous with the second S 1 component. It was concluded that atrioventricular valve closure is a necessary event in the production of S 1 and that at least in some individuals tricuspid valve closure is related to its second high frequency component.
The genetic epidemiology of alopecia areata in China
Authors: S. Yang, J. Yang, J.B. Liu, H.Y. Wang, Q. Yang, M. Gao, Y.H. Liang, G.S. Lin, D. Lin, X.L. Hu, L. Fan, X.J. Zhang
Journal: British Journal of Dermatology (2004)

Alopecia areata (AA) is hypothesized to be an organ-specific autoimmune disease with genetic predisposition and an environmental trigger. There are few clinical data in Asians.To describe the genetic epidemiological features of AA patients in China and to determine the possible genetic model for AA.Data for 1032 patients with AA were obtained by questionnaire in the Institute of Dermatology of Anhui Medical University in China from 2001 to 2003. Complex segregation analysis and heritability analysis were performed using Falconer's method, EPI INFO 6.0 and SAGE-REGTL programs.In total, 1032 AA patients (male/female ratio 1.1 : 1) were enrolled, representing 0.94% of the total number of cases seen in our outpatient clinic during that time. The mean +/- SD age of onset was 28.98 +/- 13.43 years. The difference between the mean age of onset in males and females was not significant. Most patients (82.6%) experienced their first episode of AA within the first four decades of life. A positive family history of AA was obtained in 87 patients (8.4%). The prevalence of AA in first-, second- and third-degree relatives of the proband with AA was 1.6%, 0.19% and 0.03%, respectively. These figures were higher than those in controls. A greater severity and longer duration of AA were seen in the early onset group than in the late-onset group. The early onset group also had more affected first- and second-degree relatives. The heritability of AA in first-, second- and third-degree relatives was 47.16%, 42.53% and 22.29%, respectively. Based on the REGTL results, the best model was a polygenic additive model for AA.The effect of genetic factors is strong in AA, but environmental factors such as infection and psychological stress may still play an important role. Our findings on the genetics of AA are consistent with a polygenic additive mode of inheritance.
Diagnosis and management of hyperhidrosis
Authors: R. A. Benson, R. Palin, P. J. E. Holt, I. M. Loftus
Journal: BMJ (2013)

<h3>Objective</h3> To characterize the pain-related somatosensory and psychological presentation of very early acute patients with a mild traumatic brain injury (mTBI). <h3>Methods</h3> Patients with an mTBI participated in a prospective observational study undergoing clinical, psychophysic, and psychological assessment within 72 hours after the accident. Healthy controls underwent similar protocol. <h3>Results</h3> One hundred acute patients with an mTBI (age 36 ± 12.5 [SD] years, range 19–67 years, 42 women) and 80 healthy controls (age 43 ± 14.3 years, range 24–74 years, 40 women) participated. Patients with an mTBI demonstrated a pronociceptive psychophysic response in most tests such as less efficient pressure-pain threshold–conditioned pain modulation (0.19 ±0.19±.09 vs. 0.91±.10 kg, <i>p</i> &lt; 0.001) and lower temperature needed to elicit a Pain50 response (44.72 ± 0.26°C vs 46.41 ± 0.30°C, <i>p</i> &lt; 0.001). Their psychophysic findings correlated with clinical pain measures, e.g., Pain50 temperature and mean head (<i>r</i> = −0.21, <i>p</i> = 0.045) and neck (<i>r</i> = −0.26, <i>p</i> = 0.011) pain. The pain-catastrophizing magnification subscale was the only psychological variable to show a difference from the controls, while no significant correlations were found between any psychological measures and the clinical or psychophysic pain measures. <h3>Conclusions</h3> There appears to be a dichotomy between somatosensory and psychological findings in the very early acute post-mTBI stage; while the first is altered and is associated with the clinical picture, the second is unchanged. In the context of the ongoing debate on the pathophysiologic nature of the post-mTBI syndrome, our findings support its “physical” basis, free of mental influence, at least in the short time window after the injury.
Clarke opens new financial chapter
Authors: A. Maynard
Journal: BMJ (1988)

causing low output and death.In the remaining 21 patients the cause of death was unrelated to mechanical valve failure.All of the patients in whom this phenomenon of triangulation of the aortic root was noted had undergone aortic valve replacement using the Starr-Edwards model No 2320, in which the three cage struts are cloth covered.This model was discontinued in 1976 and the current models use three stellite struts without the cloth covering.While the older models probably had greater potential to cause outflow obstruction with incorporation of the cloth covered struts into the aortic wall, the tendency to cause triangular deformity with this style of valve prosthesis remains.Although the risk of acute failure and the operative mortality associated with artificial heart valves are small, the medium and long term morbidity is not negligible.Current mechanical prostheses may well prove superior to those used previously but they are not trouble free.Conservative valve reconstruction needs to be encouraged.
Widespread Endoscopic Mucosal Resection of the Esophagus with Strategies for Stricture Prevention: A Preclinical Study
Authors: E. Rajan, C. Gostout, A. Feitoza, L. Herman, M. Knipschield, L. Burgart, S. Chung, P. Cotton, R. Hawes, A. Kalloo, S. Kantsevoy, P. Pasricha
Journal: Endoscopy (2005)

Background and Study Aims: Circumferential endoscopic mucosal resection of the esophagus is complicated by stricture formation. Prophylactic measures for avoiding such strictures have not been well studied. The aim of this preclinical study was to assess strategies for prevention of esophageal strictures in a porcine model following widespread endoscopic mucosal resection (EMR). Methods: A total of 18 60-kg pigs were included in the study. The roles of strip width (group 1), prophylactic steroids (group 2), and prophylactic stents (group 3) in the prevention of post-mucosectomy strictures were studied. Six animals were included in each group. Esophageal mucosal resection was achieved using a novel widespread EMR technique previously described by our group. Animals in group 1 underwent partial (50 % circumference) mucosal resection without prophylactic measures, while animals in the other two groups underwent circumferential mucosal resection. Animals in group 2 received 80 mg of triamcinolone injected directly into the exposed submucosal tissue (20 mg injection in four quadrants). Animals in group 3 received esophageal metal stents coated with small-intestine submucosa (SIS) that were deployed immediately post-resection. Animals were kept alive for 1 month. Results: Partial and circumferential widespread EMRs were achieved in all animals. There were no procedural complications. Repeat endoscopy at 1 month showed no strictures in group 1. Only four animals were studied in group 2, owing to the high complication rate (periesophageal abscess in all animals) with one early death. Three of the surviving animals developed mild to tight strictures. In group 3, all animals developed tight strictures; however, there was early stent migration in four animals and premature stent removal in two animals because of persistent vomiting. Conclusions: Partial widespread EMR of the esophagus heals without stricture formation and does not require prophylactic intervention. The use of deep mural steroid injection following a circumferential resection does not appear to prevent strictures and may result in serious adverse events. Short-term use of esophageal stents is inadequate for stricture prevention. However, better results may be anticipated with longer term (at least 6 weeks) stent use.
PHENOL-CAMPHOR FOR "ATHLETE'S FOOT"
Authors: Edward Francis
Journal: JAMA (1941)

I have used a combination of phenol and camphor with success for curing "athlete's foot." This preparation may be compounded as follows: Melt U. S. P. phenol and measure out 3 cc. into a mortar; weigh 3 Gm. of U. S. P. camphor, break into small pieces and add to the melted phenol. Rub until the entire mass is liquefied. Transfer into a vial with a stopper suitable for use as a dauber. Keep stoppered when not in use. Experiments indicate that the ingredients may be mixed in the proportion of 3 parts phenol and 1 part camphor. The mixture is nonirritating to the skin and may be painted between the toes several times a day, the small rubber stopper of the vial being used as a dauber. The sock may be replaced immediately without danger of corrosion. There is no discoloration of the clothing. Relief from itching is immediate.
The Medical Review Article Revisited: Has the Science Improved?
Authors: Finlay A. McAlister, Heather D. Clark, Carl van Walraven, Sharon E. Straus, Fiona M.E. Lawson, David Moher, Cynthia D. Mulrow
Journal: Annals of Internal Medicine (1999)

Background: The validity of a review depends on its methodologic quality. Objective: To determine the methodologic quality of recently published review articles. Design: Critical appraisal. Setting: All reviews of clinical topics published in six general medical journals in 1996. Measurements: Explicit criteria that have been published and validated were used. Results: Of 158 review articles, only 2 satisfied all 10 methodologic criteria (median number of criteria satisfied, 1). Less than a quarter of the articles described how evidence was identified, evaluated, or integrated; 34% addressed a focused clinical question; and 39% identified gaps in existing knowledge. Of the 111 reviews that made treatment recommendations, 48% provided an estimate of the magnitude of potential benefits (and 34%, the potential adverse effects) of the treatment options, 45% cited randomized clinical trials to support their recommendations, and only 6% made any reference to costs. Conclusions: The methodologic quality of clinical review articles is highly variable, and many of these articles do not specify systematic methods.
Lung Function in Cotton-Textile Workers
Authors: GERALD J. BECK
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Lung Function in Cotton-Textile WorkersGERALD J. BECK, PH.D., E. NEIL SCHACHTER, M.D., LUCINDA R. MAUNDER, M.A., RICHARD S.F. SCHILLING, M.D., D.SC.GERALD J. BECK, PH.D.Search for more papers by this author, E. NEIL SCHACHTER, M.D.Search for more papers by this author, LUCINDA R. MAUNDER, M.A.Search for more papers by this author, RICHARD S.F. SCHILLING, M.D., D.SC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-150_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Pratt and Lynn, in their continuing response (1) to our study of chronic lung disease in cotton-textile workers (2, 3), have again misread our figures and tables in their attempt to support their hypothesis that lung function in nonsmoking workers may improve after these workers retire from work in the mills.The changes in lung function over the 6-year follow-up period of our study (2) given in Figure 1 pertain to all cotton-textile workers, not just those still actively working, as Pratt and Lynn misstate. This fact invalidates their conclusion that the active workers have worsening lung...References1. PRATTLYNN PW. Cotton dust, smoking, and the lung [Letter]. Ann Intern Med. 1984;100:618-9. LinkGoogle Scholar2. BECKSCHACHTERMAUNDERSCHILLING GELR. A prospective study of chronic lung disease in cotton textile workers. Ann Intern Med. 1982;97:645-51. LinkGoogle Scholar3. BECKMAUNDERSCHACHTERSCHILLING GLER. Follow-up of Active and Retired Cotton Textile Workers: Report to the U.S. Department of Labor. Springfield, Virginia: National Technical Information Service; 1982. (Publication no. PB 82-240516). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GERALD J. BECK, PH.D.; E. NEIL SCHACHTER, M.D.; LUCINDA R. MAUNDER, M.A.; RICHARD S.F. SCHILLING, M.D., D.SC.Affiliations: Yale University School of Medicine New Haven, CT 06510 Medical Research Council London England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEndotoxins isolated from the air of a Danish paper mill and the relation to change in lung function: An 11-year follow-up 1 July 1984Volume 101, Issue 1Page: 150-150KeywordsLungs ePublished: 1 December 2008 Issue Published: 1 July 1984 PDF downloadLoading ...
Lessons in Medical Humanism: The Case of Montaigne
Authors: Alan G. Wasserstein
Journal: Annals of Internal Medicine (2007)

Michel de Montaigne, the great French humanist and inventor of the personal essay, suffered from frequent and severe renal colic. He wrote about his illness in his travel journal and in his last and greatest essay, “Of Experience.” In his illness narratives, Montaigne integrated disease and suffering into his life and art. He humanized rather than conquered his disease. A mature humanism replaced his youthful Stoic philosophy of detachment and disengagement and provides a worthy model for our own medical humanism.
Gallbladder Visualization after Hepatic Washout
Authors: WALTER E. DRANE
Journal: Clinical Nuclear Medicine (1987)

Washout of hepatic activity on hepatobiliary scintigraphy has been used as a rationale to stop imaging during evaluation for acute cholecystitis. A case is presented that shows gallbladder visualization after the liver has washed out on analog images. The need for strict application of delayed imaging at hepatobiliary scintigraphy for acute cholecystitis is reemphasized.
The Effects of Intravenous Apresoline (Hydralazine) on Cardiovascular and Renal Function in Patients with and without Congestive Heart Failure
Authors: WALTER E. JUDSON, WILLIAM HOLLANDER, ROBERT W. WILKINS
Journal: Circulation (1956)

Intravenous Apresoline is a powerful renal vasodilator in cardiac as well as in noncardiac patients. In hypertensive patients in congestive heart failure, the drug produces a striking improvement in both cardiovascular and renal function. The increases in renal plasma flow are inconsistently related to changes in arterial pressure and cardiac output Unlike many hypotensive drugs, Apresoline usually causes no decrease in the renal excretion of sodium and water. Circulatory collapse produced by the drug may occur in the presence of an increased cardiac output but is accompanied by a deterioration of the arterial pressure pulse and a reduction in sodium and water excretion.
Brand-Name Prescription Drug Use Among Veterans Affairs and Medicare Part D Patients With Diabetes
Authors: Walid F. Gellad, Julie M. Donohue, Xinhua Zhao, Maria K. Mor, Carolyn T. Thorpe, Jeremy Smith, Chester B. Good, Michael J. Fine, Nancy E. Morden
Journal: Annals of Internal Medicine (2013)

Medicare Part D and the U.S. Department of Veterans Affairs (VA) use different approaches to manage prescription drug benefits, with implications for spending. Medicare relies on private plans with distinct formularies, whereas the VA administers its own benefit using a national formulary.
Tobacco: Promotion and Smoking
Authors: Mike Males
Journal: JAMA (1992)

<h3>To the Editor.</h3> —DiFranza et al<sup>1</sup>and Pierce et al<sup>2</sup>show that Camel cigarette advertising inclines young smokers to choose that brand. Yet from 1986 to 1990, coincident with Camel's promotion of its Old Joe logo, neither national surveys<sup>3</sup>nor the authors' own data show any real growth in teenage smoking. The comparison by Pierce et al of 1986 US and 1990 California data also indicates that the switch to Camels did not coincide with any smoking increase among 18- to 29-year-olds compared with older age groups. The five-state sample of DiFranza et al further shows that despite exposure of nearly all youth to $3 billion in deceptively alluring cigarette ads every year, 70% to 80% continue to reject smoking, as in prior years. Alarms of a new army of advertising-recruited child smokers are unwarranted by the available evidence. The literature is replete with exuberant findings, later
The Extraordinary Dr Biggs
Authors: Howard Markel
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EVALUATION OF BLOOD BRAIN BARRIER PERMEABILITY IN HUMAN BRAIN TUMORS WITH POSITRON TCMOGRAPHY AND Ga-68 EDTA
Authors: Randall A. Hawkins, Peter D. Grimm, Joseph A. Wapenski, Sung-Cheng Huang, Peter Greenberg, Michael E. Phelps, Robert G. Parker, Guy Juillard, David E. Kuhl
Journal: Clinical Nuclear Medicine (1983)

Hawkins, Randall A.; Grimm, Peter D.; Wapenski, Joseph A.; Huang, Sung-Cheng; Greenberg, Peter; Phelps, Michael E.; Parker, Robert G.; Juillard, Guy; Kuhl, David E.Author Information
Thyroid Function Tests Simulating Graves' Disease in Alcoholic Hepatitis
Authors: DAVID D. STUART
Journal: Annals of Internal Medicine (1978)

Brief Reports1 October 1978Thyroid Function Tests Simulating Graves' Disease in Alcoholic HepatitisDAVID D. STUART, M.D., ALVIN L. SCHULTZ, M.D., F.A.C.P.DAVID D. STUART, M.D.Search for more papers by this author, ALVIN L. SCHULTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-514 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe liver may be a major site of extrathyroidal conversion of thyroxine (T4) to triiodothyronine (T3). Patients with alcoholic liver disease of several types have been observed to have mild but significant elevations of serum thyrotropin (TSH) and free T4, and normal or low free T3compared with control populations (1, 2). Estimated T3production rate in patients with hepatic cirrhosis is substantially less than that of normal persons, whereas the production rate of reverse T3is unchanged (3). These observations suggest that, in patients with liver disease, a compensatory increase in TSH and in thyroidal hormonogenesis occurs in response...References1. NOMURAPITTMANCHAMBERSBUCKSHIMIZU SCJMT: Reduced peripheral conversion of thyroxine to triiodothyronine in patients with hepatic cirrhosis. J Clin Invest 56:643-652, 1975 CrossrefMedlineGoogle Scholar2. CHOPRASOLOMONCHOPRAYOUNGCHUA TECO IDURG: Thyroid hormones and thyrotropin in hepatic cirrhosis. Evidence for euthyroidism despite subnormal serum triiodothyronine. J Clin Endocrinol Metab 39:501-511, 1974 CrossrefMedlineGoogle Scholar3. CHOPRA I: An assessment of daily production and significance of thyroidal secretion of 3,3′, 5′-triiodothyronine (reverse T3) in man. J Clin Invest 58:32-40, 1976 CrossrefMedlineGoogle Scholar4. WONGSCHULTZ EA: Changing values for the normal thyroid radioactive iodine uptake test. JAMA 238:1741-1743, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hennepin County Medical Center The University of Minnesota Medical School Minneapolis, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAlcohol, Hormones, and MetabolismChanges in thyroid function tests in physical and psychiatric diseasesThyroid Hormones and the LiverEffects of Chronic Ethanol Administration on 0 2 Consumption in Whole Body and Perfused Liver of the RatAssessment of Thyroid Function in Chronic Alcoholics 1 October 1978Volume 89, Issue 4Page: 514-515KeywordsAlcoholicsCirrhosisHepatitis ALiverLiver diseasesPopulation statisticsThyroidThyroid-stimulating hormoneThyroxineTriiodothyronine Issue Published: 1 October 1978 PDF DownloadLoading ...