Weight Loss in Mildly to Moderately Obese Patients with Obstructive Sleep Apnea
Authors: Philip L. Smith, Avram R. Gold, Deborah A. Meyers, Edward F. Haponik, Eugene R. Bleecker
Journal: Annals of Internal Medicine (1985)

Article1 December 1985Weight Loss in Mildly to Moderately Obese Patients with Obstructive Sleep ApneaPHILIP L. SMITH, M.D., AVRAM R. GOLD, M.D., DEBORAH A. MEYERS, Ph.D., EDWARD F. HAPONIK, M.D., EUGENE R. BLEECKER, M.D.PHILIP L. SMITH, M.D., AVRAM R. GOLD, M.D., DEBORAH A. MEYERS, Ph.D., EDWARD F. HAPONIK, M.D., EUGENE R. BLEECKER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-850 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapeutic effects of weight loss were evaluated in 15 hypersomnolent patients with moderately severe obstructive sleep apnea. As patients decreased their body weight from 106.2 ± 7.3 kg (mean ± SE) to 96.6 ± 5.9 kg, apnea frequency fell from 55.0 ± 7.5 to 29.2 ± 7.1 episodes/h (p< 0.01) in non-rapid-eye-movement sleep with an associated significant decline in the mean oxyhemoglobin saturation during the remaining episodes of sleep apnea from 11.9 ± 2.4% to 7.9 ± 1.9% (p< 0.02). Sleep patterns also improved, with a reduction in stage I sleep from 40.2 ± 7.3% to 23.5 ± 4.8% (p< 0.01), and a rise in stage II sleep from 37.3 ± 7.0% to 49.4 ± 4.6% (p< 0.03). In the 9 patients with the most marked fall in apnea frequency, the tendency toward daytime hypersomnolence was decreased (p< 0.05). No significant changes in sleep patterns occurred in 8 age- and weight-matched control patients who did not lose weight. Moderate weight loss alone can alleviate sleep apnea, improve sleep architecture, and decrease daytime hypersomnolence....References1. GUILLEMINAULTVANHOEDMITLER CDJM. 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Stat Bull Metrop Life Insur Co. 1959;40:1-4. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: ▸From the Johns Hopkins Sleep Disorders Center, Division of Pulmonary Medicine, Department of Medicine, Francis Scott Key Medical Center, Johns Hopkins Medical Institutions; Baltimore, Maryland. 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