tbuckley/cabot-search huggingface dataset:
Association of Bisphenol A With Diabetes and Other Abnormalities
Authors: Ming Wei
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study
Authors: Glenda E Gray, Zoe Moodie, Barbara Metch, Peter B Gilbert, Linda-Gail Bekker, Gavin Churchyard, Maphoshane Nchabeleng, Koleka Mlisana, Fatima Laher, Surita Roux, Kathryn Mngadi, Craig Innes, Matsontso Mathebula, Mary Allen, M Julie McElrath, Michael Robertson, James Kublin, Lawrence Corey
Journal: The Lancet Infectious Diseases (2014)
FATAL ANURIA FOLLOWING SULFADIAZINE THERAPY
Authors: C. Alexander Hellwig
Journal: JAMA (1942)

The literature contains reports on nearly 1,000 patients treated with sulfadiazine. Only 2 instances have been recorded in which urinary suppression followed the administration of this compound. In both cases cystoscopy and pelvic lavage promptly relieved the renal failure. 1   In contrast to these clinical reports, which suggest a low toxicity of sulfadiazine, observations on experimental animals are less optimistic. Lehr and Antopol 2 found that, in albino rats, sulfadiazine may produce acute precipitation of the free acid in the renal tubules, and because of the poor solubility of the drug severe degeneration of the tubular epithelium may result.  Gross, Cooper and Hagan 3 gave sulfadiazine in different doses to mice and rats. Of 70 mice, 15 died following the medication. In one third of all the animals almost all collecting tubules were blocked by crystalline masses. In about one fifth of the animals crystals were found also in the
Dietary Sodium: Milligrams or Milliequivalents?
Authors: RICHARD M. FREEMAN
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 June 1972Dietary Sodium: Milligrams or Milliequivalents?RICHARD M. FREEMAN, M.D.RICHARD M. FREEMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-6-1043 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am perturbed by an incongruity of modern medicine: we ingest sodium in milligram quantities; we excrete it in milliequivalents! When a hospital patient requires dietary sodium restriction, the physician orders a diet containing perhaps 400 mg of sodium. He does this despite the fact that the patient's plasma sodium is expressed in mEq/litre and the urinary sodium probably in mEq/24 hr. If one asks the physician how much sodium is in a litre of normal saline, he answers 154 mEq, not 9000 mg! All of our measurements of sodium metabolism in a patient are in terms...Reference1. WATTMERRILL BA: Composition of Foods. Agricultural Handbook No. 8. Washington, D.C., United States Department of Agriculture, 1963 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine University of Iowa Hospitals and Clinics The University of Iowa Iowa City, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDiet manual in a large teaching hospital: philosophy and purpose 1 June 1972Volume 76, Issue 6Page: 1043-1044KeywordsBlood plasmaDietSaline solutionsSodium Issue Published: 1 June 1972 PDF DownloadLoading ...
Appropriate statistical test in comparative ulcer healing studies
Authors: J S C Verschoor, J S E Benyon
Journal: Gut (1986)

Frost L, Wiholm BE.An evaluation of the frequency of anti-inflammatory and analgesic drug intake among patients with acute gastrointestinal bleed- ing.Proceedings 2nd international conference of side- effects of anti-inflammatory analgesic drugs.Cambridge, August 1985.Appropriate statistical test in comparative ulcer healing studies SIR,-Boyd and Marks' in their letter state that the statistical method used by Lam et al,2 namely, a X2-test (without Yates' correction), is inappropriate for the analysis of their data.For many years there has been some controversy in the statistical literature as to whether Yates' on June 6, 2023 by guest.
Coeliac disease and bone mineral density in adult female patients.
Authors: L R Pistorius, W H Sweidan, D W Purdie, S A Steel, S Howey, J R Bennett, D R Sutton
Journal: Gut (1995)

A cross sectional study was undertaken to examine the relationship between coeliac disease and bone mineral density. The 135 female coeliac patients registered on the database of the Department of Gastroenterology at Hull Royal Infirmary were approached by letter, advising them of a potential risk of osteoporosis and inviting them to undergo bone densitometry. A total of 81 registered women (60%) attended the Osteoporosis Laboratory, Princess Royal Hospital and underwent dual energy x ray absorptiometry at the lumbar spine (L2-L4) and femoral neck. Historical data relating to the time of diagnosis and adherence to a gluten free diet were obtained. A control group was selected from the local normal population and was first matched for height, weight, and menopausal status. Postmenopausal patients were then further matched to controls of equivalent menopausal age. In coeliac patients, bone mineral density expressed in g/cm2 as mean (SD) was significantly lower at the lumbar spine (1.076 (0.186)) than in the control group (1.155 (0.143), p < 0.001). This was also the case at the femoral neck (0.887 (0.142) versus 0.965 (0.127), p < 0.001). When the coeliac patients were stratified by menopausal status, it was found that femoral neck bone mineral density was significantly below control values in both premenopausal and postmenopausal women. Spinal bone mineral density exhibited a significant decrement only in the postmenopausal group. The age at diagnosis of coeliac disease and adherence to a gluten free diet did not influence bone mineral density at either hip or spine. These results confirm coeliac patients' higher risk of osteopenia. Coeliac disease should be added to the list of medical conditions which constitute an indication for bone densitometry in order that the individual risk of osteoporosis related fracture may be determined.
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin.
Authors: T Nosaka, H Ohno, S Doi, S Fukuhara, H Miwa, K Kita, S Shirakawa, T Honjo, M Hatanaka
Journal: Journal of Clinical Investigation (1988)

Acute biphenotypic leukemia composed of lymphoblasts and myeloblasts developed in a patient with T lymphoblastic lymphoma (T-LBL) who had an anterior mediastinal mass. A novel myeloid cell line, termed TK-1, has been established from his peripheral blood after the leukemic conversion. The identical rearranged pattern of T cell receptor gamma-chain gene was observed among the DNAs derived from lymph node cells in the lymphoma phase, the myeloid cell line TK-1, and the subclones with different karyotypes (TK-1B and TK-1D), which showed that myeloid cells had been derived from the T-LBL of the same patient. This finding demonstrates that phenotypic conversion occurs in the clonally propagating tumor cells and suggests that some hematopoietic cells retain the capacity to adopt either lineage.
Role of Inducible Nitric Oxide Synthase Pathway in the Development of Non-eosinophilic Asthma
Authors: H. Park, S. Sohn, C. Park, H. Kwon, D. Kim, S. Kim, Y. Chang, S. Lee, D. Choi, S. Cho, S. Chang, K. Min, Y. Kim
Journal: Journal of Allergy and Clinical Immunology (2007)
Sitting-time and 9-year all-cause mortality in older women
Authors: Toby G Pavey, GMEE (Geeske) Peeters, Wendy J Brown
Journal: British Journal of Sports Medicine (2012)

Background Studies of mid-aged adults provide evidence of a relationship between sitting-time and all-cause mortality, but evidence in older adults is limited. The aim is to examine the relationship between total sitting-time and all-cause mortality in older women. Methods The prospective cohort design involved 6656 participants in the Australian Longitudinal Study on Women's Health who were followed for up to 9 years (2002, age 76–81, to 2011, age 85–90). Self-reported total sitting-time was linked to all-cause mortality data from the National Death Index from 2002 to 2011. Cox proportional hazard models were used to examine the relationship between sitting-time and all-cause mortality, with adjustment for potential sociodemographic, behavioural and health confounders. Results There were 2003 (30.1%) deaths during a median follow-up of 6 years. Compared with participants who sat &lt;4 h/day, those who sat 8–11 h/day had a 1.45 times higher risk of death and those who sat ≥11 h/day had a 1.65 times higher risk of death. These risks remained after adding sociodemographic and behavioural covariates, but were attenuated after adjustment for health covariates. A significant interaction (p=0.02) was found between sitting-time and physical activity (PA), with increased mortality risk for prolonged sitting only among participants not meeting PA guidelines (HR for sitting ≥8 h/day: 1.31, 95% CI 1.07 to 1.61); HR for sitting ≥11 h/day: 1.47, CI 1.15 to 1.93). Conclusions Prolonged sitting-time was positively associated with all-cause mortality. Women who reported sitting for more than 8 h/day and did not meet PA guidelines had an increased risk of dying within the next 9 years.
Mattresses as a winter refuge for house‐dust mite populations
Authors: R. de Boer, K. Kuller
Journal: Allergy (1997)

House‐dust mites are a major source of allergens. Beds are often heavily infested. It is conceivable that, during the winter period in temperate climates, the ambient indoor air is too dry for their survival, but that mites can still survive in beds where the humidity is raised when the bed is occupied. To investigate whether house‐dust mites can take advantage of daily episodes with elevated humidity to restore water balance, we exposed mites to spells of high humidity (90% relative humidity [RH]), lasting 0,1.5, 3, 6, or 12 h, once every day, while the humidity was low (10% RH) during the rest of the time. Survival was markedly promoted when only 1.5h of moist air per day was given. Three hours of moist air per day allowed the mites to reproduce. The same average humidity but at a constant level would have been lethal to the mites. Thus, average humidity can be misleading as an indicator of mite survival conditions. Measurements of relative humidity were made inside the foam core of a mattress and underneath the ticking. The rise of humidity occurring when the bed was occupied was often insufficient for the mites, because the temperature rose at the same time. At higher temperatures, mites required a higher relative humidity, abolishing the effect of the simultaneous rise in absolute humidity. Thus, it seems quite possible to regulate house‐dust mite numbers also in beds by reducing the water content of the ambient air. The rules governing changes in temperature and humidity inside a bed may be simple enough to allow assessment of house‐dust mite living conditions by measurements in the ambient air.
No Failures From Hadassah
Authors: M. Prywes
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Our attention was called to the "Medical Licensure Statistics for 1963" inThe Journal(<b>188</b>:877, 1964). We were greatly surprised at the extraordinarily high rate of failures among the graduates of the Hebrew University Hadassah Medical School in Jerusalem at the state board examinations (p 921). We are at a loss to reconcile these failures with the consistently excellent results obtained by our graduates at the ECFMG examinations during the past few years. In seeking an explanation of this contradiction, we applied to Donald C. Walker, MD, secretary for the board of medical examiners of the state of New York, because the figures showed 1 candidate passed and 19 failed in New York, the principal area of discrepancy. We were pleased to learn from his reply that these figures were based on a clerical error. Apparently, failures among graduates of the medical school listed immediately after
Evolution of a New Specialty
Authors: Michael E. Zenilman
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Preconception Gender Selection
Authors: John A. Robertson
Journal: The American Journal of Bioethics (2001)

Safe and effective methods of preconception gender selection through flow cytometric separation of X- and Y-bearing sperm could greatly increase the use of gender selection by couples contemplating reproduction. Such a development raises ethical, legal, and social issues about the impact of such practices on offspring, on sex ratio imbalances, and on sexism and the status of women. This paper analyzes the competing interests in preconception gender selection, and concludes that its use to increase gender variety in a family, and possible for selecting the gender of firstborn, might in many instances be ethically acceptable.
Abstract 3330: HER2 overexpression induces membrane deformation that increases cell motility
Authors: Inhee Chung, Mike Reichelt, Donald Dowbenko, Ira Mellman, Mark Sliwkowski
Journal: Cancer Research (2014)

Abstract Approximately 20% of breast cancers (BC) are characterized by the gene amplification and overexpression of HER2, a member of the ErbB/HER receptor family. While targeted therapies against HER2 effectively delay disease progression in this BC subtype, details of how overexpressed HER2s drive these tumors to malignancy are still unclear. To better understand this process, we investigated various cellular responses to HER2 overexpression in individual live cells. We developed novel single receptor diffusion analyses that determine the activation status of HER2 by diffusivity, to estimate average HER2 activity per single cell. Surprisingly, we found HER2 overexpression induces membrane deformation, which depends only on the HER2 density, but not the receptor activation status. Moreover, this membrane deformation lowers the available surface area for formation of focal adhesion sites, resulting in reduced cell adhesion and increased cell motility. These findings suggest there are signaling-independent roles of HER2 overexpression in disease progression of HER2 positive BCs. Citation Format: Inhee Chung, Mike Reichelt, Donald Dowbenko, Ira Mellman, Mark Sliwkowski. HER2 overexpression induces membrane deformation that increases cell motility. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3330. doi:10.1158/1538-7445.AM2014-3330
Influenza Immunization and the Press
Authors: ELIZABETH BARRETT-CONNOR
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 March 1978Influenza Immunization and the PressELIZABETH BARRETT-CONNOR, M.D.ELIZABETH BARRETT-CONNOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-428_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest the December article by Rubin and Hendy on swine influenza and the news media (Ann Intern Med87:769-774, 1977). I found much of their text pejorative and unreferenced, which may illustrate why physicians and perhaps the Center for Disease Control (CDC) were reluctant to talk with the press. For example, they start by stating that the inoculation program was a gamble that failed. Did the gamble fail? When one buys fire insurance for one's house, the absence of a fire is rarely considered to be a failure of the fire insurance. In the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of California, San Diego School of Medicine La Jolla, CA 92093 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1978Volume 88, Issue 3Page: 428-428KeywordsInoculationSwine influenza Issue Published: 1 March 1978 PDF DownloadLoading ...
Health in a Developing World
Authors: Mehdi Tavassoli
Journal: JAMA (1974)

Man in underdeveloped countries, or the disinherited in all parts of the world, perceives life not as a flowering or a development of an essential productiveness but as a permanent struggle against an omnipresent death.<sup>1</sup> Frantz Fanon THIS grim perception is reflected in several recent studies<sup>2,3</sup>that have disclosed two astounding trends. <h3>Two Trends</h3><h3>Trend of Health Indices.—</h3> During the first half of this century, modest progress was made towards improving world health. In the third quarter, progress halted or, worse, regressed. Virtually every measure of health care has remained static. Even more disturbing, the rates of improvement are worse in poor countries than in the rich. There is room for improvement that has not come about. For instance, the death rate from tuberculosis has remained static both in Chile and in the United States. But in Chile it is still five times higher than in the United
A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality
Authors: Val Mann, Emma E. Hobson, Baohua Li, Tracy L. Stewart, Struan F.A. Grant, Simon P. Robins, Richard M. Aspden, Stuart H. Ralston
Journal: Journal of Clinical Investigation (2001)

Osteoporosis is a common disease with a strong genetic component. We previously described a polymorphic Sp1 binding site in the COL1A1 gene that has been associated with osteoporosis in several populations. Here we explore the molecular mechanisms underlying this association. A meta-analysis showed significant associations between COL1A1 “s” alleles and bone mineral density (BMD), body mass index (BMI), and osteoporotic fractures. The association with fracture was stronger than expected on the basis of the observed differences in BMD and BMI, suggesting an additional effect on bone strength. Gel shift assays showed increased binding affinity of the “s” allele for Sp1 protein, and primary RNA transcripts derived from the “s” allele were approximately three times more abundant than “S” allele–derived transcripts in “Ss” heterozygotes. Collagen produced from osteoblasts cultured from “Ss” heterozygotes had an increased ratio of α1(I) protein relative to α2(I), and this was accompanied by an increased ratio of COL1A1 mRNA relative to COL1A2. Finally, the yield strength of bone derived from “Ss” individuals was reduced when compared with bone derived from “SS” subjects. We conclude that the COL1A1 Sp1 polymorphism is a functional genetic variant that predisposes to osteoporosis by complex mechanisms involving changes in bone mass and bone quality.
Intranasal Verapamil in Allergen‐Induced Rhinitis
Authors: GLAUS SECHER, SUSANNE BROFELDT, NIELS MYGIND
Journal: Allergy (1983)

Twenty‐six pollen‐allergic subjects participated in a double‐blind, placebo‐controlled trial of the protective effect of the calcium antagonist, verapamil, on allergen‐provoked nasal symptoms. Intranasal verapamil, 1 mg, had a weak protective effect in that “tickling score” was 22% lower ( P &lt; 0.01) and the number of sneezes 29% lower (nonsignificant) after verapamil as compared with placebo pretreatment. There were no differences with regard to nasal blockage or discharge. It is concluded tha the verapamil spray used, cannot be recommended for clinical trials, but that further investigations of other formulations of calcium antagonists are justified in order to analyse the potential role of this type of drugs in the treatment of allergic rhinitis.
Report from a Viral Hepatitis Policy Forum on implementing the WHO framework for global action on viral hepatitis in North Asia
Authors: Ding-Shinn Chen, Stephen Locarnini, Suzanne Wait, Si-Hyun Bae, Pei-Jer Chen, James Y.Y. Fung, Hong Soo Kim, Sheng-Nan Lu, Joseph Sung, Junko Tanaka, Takaji Wakita, John Ward, Jack Wallace
Journal: Journal of Hepatology (2013)
Clinical Evaluation of Propatylnitrate in Angina Pectoris
Authors: G. Sandler
Journal: BMJ (1961)

~~~~~~~~~~~~~~~~~~~~~~~~MEDICAL JOURNAL as an adjuvant to ganglion and adrenergic blocking drugs in the treatment of premalignant and malignant hypertension. Summary and ConclusionsA co-operative clinical trial in general practice carried out by three practitioners in Glasgow is reported.The drug concerned was a new hypotensive agent, methoserpidine (" decaserpyl "), a synthetic isomer of reserpine.The effect of the drug was investigated mainly in 43 patients with essential (benign) hypertension.A definite hypotensive action was demonstrated in approximately two-thirds of the patients and was judged sufficient to be certainly beneficial clinically in one-third.Almost all the patients obtained symptomatic improvement.The drug was found to be virtually free from side-effects and tranquillizing action.Dosage of the drug should usually be 30 mg. daily initially, it being subsequently increased or decreased, if required, within the range of 10-60 mg.daily.The findings broadly confirm the results reported in other investigations of this drug.Our experience indicates that methoserpidine is a useful drug for the management of mild and moderate cases of essential hypertension in general practice.We would like to express our appreciation to Roussel Laboratories Limited for making available supplies of decaserpyl, and to Dr. J. J.