tbuckley/cabot-search huggingface dataset:
Prophylactic antiarrhythmic therapy of high-risk survivors of myocardial infarction: lower mortality at 1 month but not at 1 year.
Authors: S H Gottlieb, S C Achuff, E D Mellits, G Gerstenblith, K L Baughman, L Becker, N C Chandra, S Henley, J O Humphries, C Heck
Journal: Circulation (1987)

To determine whether prophylactic antiarrhythmic therapy influences mortality in high-risk patients after acute myocardial infarction, 143 such patients were randomized in a double-blind individually dose-adjusted, placebo-controlled trial an average of 14 +/- 7 days after myocardial infarction and followed for 1 year. Patients were judged to be at high risk on the basis of (1) ejection fraction less than 40% (n = 60), (2) arrhythmias of Lown class 3 or higher (n = 26), or (3) both (n = 57). Aprindine was chosen because of its long half-life, few side effects, and antiarrhythmic efficacy. Baseline characteristics in the treatment arms did not differ. Holter-detected arrhythmias were reduced in aprindine-treated patients at 3 months (p less than .001) and at 1 year (p less than .001). One patient was lost to follow-up; in the remaining patients 1 year mortality was 20% (28/142; 12 aprindine and 16 placebo). There was no significant difference between the two study arms in overall mortality and sudden death. However, among those who died, median duration of survival was longer in aprindine-treated patients (86 vs 21.5 days) (p = .04). Although antiarrhythmic treatment with aprindine of high-risk patients after myocardial infarction does not affect 1 year survival, mortality appears to be delayed; thus there may be a role for short-term treatment before more definitive therapy such as surgery.
Protection against immune haemolytic disease of newborn infants by maternal monocyte-reactive IgG alloantibodies (anti-HLA-DR)
Authors: M.C. Dooren, R.W.A.M. Kuijpers, E.C. Joekes, E. Huiskes, R. Goldschmeding, M.A.M. Overbeeke, C.P. Engelfriet, A.E.G.Kr. von dem Borne, W.H. Ouwehand
Journal: The Lancet (1992)
Short and long-term risks of topical drugs
Authors: A. ZESCH
Journal: British Journal of Dermatology (1986)

Journal Article Short and long‐term risks of topical drugs Get access A. ZESCH A. ZESCH Arzneimittelinstitut des BGA (Federal Health Office), D‐1000 Berlin 65, Federal Republic of Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s31, 1 August 1986, Pages 63–70, https://doi.org/10.1111/j.1365-2133.1986.tb02111.x Published: 01 August 1986
Investigating hip pain in a well child
Authors: A Gough-Palmer, K McHugh
Journal: BMJ (2007)

A 9 year old girl with a history of conservatively managed left sided Perthes' (Legg-Calvé-Perthes) disease presented to her orthopaedic team via her general practitioner with onset of right hip pain and subsequent limp. She was otherwise well. On clinical examination she had a limp with moderate pain and some limitation of abduction and internal rotation. She did not have a fever, and routine haematology and biochemistry gave normal results. Assuming the disease can confidently be localised to the hip (rather than knee, pelvis, or lower back), a presumptive diagnosis of the painful hip is reasonable, based on age and presentation.
Not all those who died after Hillsborough did so by 3 15 pm
Authors: E. Walker
Journal: BMJ (1997)

Editor—In his recent letter David Slater misses the point that my review of the Hillsborough drama was just that—a review of a television programme.1 2 The scene in which he was portrayed speaking to an off duty Liverpool policeman was included in the drama, and this is the reason I referred to it in my article. The veracity of the scene is …
Evaluation of the nephrotoxicity of complex mixtures containing organics and metals: advantages and disadvantages of the use of real-world complex mixtures.
Authors: J E Simmons, R S Yang, E Berman
Journal: Environmental Health Perspectives (1995)

As part of a multidisciplinary health effects study, the nephrotoxicity of complex industrial waste mixtures was assessed. Adult, male Fischer 344 rats were gavaged with samples of complex industrial waste and nephrotoxicity evaluated 24 hr later. Of the 10 tested samples, 4 produced increased absolute or relative kidney weight, or both, coupled with a statistically significant alteration in at least one of the measured serum parameters (urea nitrogen (BUN), creatinine (CREAT), and BUN/CREAT ratio). Although the waste samples had been analyzed for a number of organic chemicals and 7 of the 10 samples were analyzed also for 12 elemental metals and metalloids, their nephrotoxicity was not readily predicted from the partial chemical characterization data. Because the chemical form or speciation of the metals was unknown, it was not possible to estimate their contribution to the observed biological response. Various experimental approaches, including use of real-world complex mixtures, chemically defined synthetic mixtures, and simple mixtures, will be necessary to adequately determine the potential human health risk from exposure to complex chemical mixtures.
POLYCYSTIC KIDNEYS WITH BILATERAL NEPHROLITHIASIS
Authors: Alexander Hamilton Peacock
Journal: JAMA (1930)

Polycystic kidneys are always spectacular, on account of their unusual size, the fact that nine out of ten are bilateral, and the limitations of surgery that can be safely employed.  The occurrence of calculi in this type of kidney is scarcely mentioned in the literature. Thomas 1 reported a case of staghorn calculus in a kidney presenting multiple cysts but not polycystic. In discussing this case, Greene 2 stated that he saw a case of staghorn calculus in a polycystic kidney; no operation was done. He quoted Sieber as also having seen 8 cases of calculi in 220 polycystic cases and Braasch as having seen 4 calculi in 31 cases of polycystic disease.  Young 3 states that polycystic kidney may be the site of practicallyher renal disease, as calculus, hydronehydronephrosis, pyelonephritis or tuberculosis.  Surgery on polycystic kidneys has always carried a high rate of mortality. Brin 4 reported a mortality of 31.8
Up regulation of the production of tumour necrosis factor alpha and interferon gamma by T cells in ankylosing spondylitis during treatment with etanercept
Authors: J Zou
Journal: Annals of the Rheumatic Diseases (2003)

<b>Background:</b> Treatment of active ankylosing spondylitis (AS) with the recombinant, soluble tumour necrosis factor α (TNFα) receptor molecule etanercept has been shown to be clinically highly effective. The precise mechanism of action, however, is not known. <b>Objective:</b> To assess the change in the cytokine secreting ability of CD4+ and CD8+ T cells and macrophages during etanercept treatment. <b>Patients and methods:</b> Peripheral blood mononuclear cells from 10 patients with AS treated with 25 mg etanercept and 10 patients with AS treated with placebo were investigated during treatment given twice weekly subcutaneously. Production of cytokines by T cells was investigated after in vitro stimulation by flow cytometry. <b>Results:</b> Twelve weeks of etanercept treatment induced a significant increase in the number of interferon γ (IFNγ) positive (14.2% (9.6–19.5%) before <i>v</i> 24.4% (13.4–36.4%) after) and TNFα positive CD4+ T cells (p=0.008 for both cytokines) and IFNγ positive (37.5% (19.0–45.4%) before <i>v</i> 52.9% (33.2–60.0%) after) and TNFα positive CD8+ T cells (p=0.008 for both cytokines) upon phorbol myristate acetate/ionomycin stimulation, but not in the placebo group. Furthermore, etanercept treatment induced a significant increase in the number of IFNγ positive CD8+ T cells (p=0.024 at 12 weeks) and a non-significant increase of TNFα positive CD8+ T cells after in vitro stimulation with the aggrecan derived peptides. <b>Conclusions:</b> Neutralisation of peripheral TNFα does not induce a down regulation of the ability of T cells to produce TNFα but rather an up regulation, possibly due to a counterregulatory mechanism.
The Acanthocyte in Cirrhosis with Hemolytic Anemia
Authors: CHARLES C. DOUGLASS
Journal: Annals of Internal Medicine (1968)

A patient with severe cirrhosis and hemolytic anemia associated with marked acanthocytosis is described. Wet preparations revealed the acanthocytes to be rigid and nonpliable without rouleaux formation. Numerous in vitro studies failed to demonstrate any additional abnormalities.51Cr-labeled red cell survival studies demonstrated a markedly shortened survival both in the patient and in a normal recipient, while the patient's cells survived normally in an asplenic individual. The present case, and previous findings in studies of the acanthocytes associated with cirrhosis, demonstrate that they are significantly different in character from those found in a-beta-lipoproteinemia. It is suggested that the shortened life-span of the acanthocytes in our patient may be due to their nonpliable character, leading to sequestration in the spleen.
PAUL EMILE BOTTA-ASSYRIOLOGIST, PHYSICIAN
Authors: Frederick Stenn
Journal: JAMA (1960)

<h3>To the Editor:—</h3> As Thomas Young, M.D., was the father of Egyptology, so, too, was Paul Botta, M.D., a father of Assyriology. The noted archeologist Sir Henry Layard wrote of Botta, "To him is due the honor of having found the first Assyrian monument." Son of the Italian historian Carlo Botta, Paul was born in Turin in 1802 and died in 1870. He studied under Cruveilhier, Orfila, Andral, and Dupuytren at the Faculty of Medicine at Paris, taking his doctorate in 1830 with a thesis, "On the Use of Smoking Opium." As a surgeon he embarked in 1826 on the brig "Heros" for a three-year trip around the world, collecting scientific material wherever he went. Later he served as military physician to the Khedive, Mehemet Ali, of Egypt and assisted in operations on the Arabic peninsula and Sennar. Here he obtained a large zoological collection, which he brought to Cairo.
The Morphology of Intercoronary Anastomoses in Chronic Coronary Artery Occlusion
Authors: W. Schaper, J. Schaper, R. Xhonneux, R. Vandesteene
Journal: Cardiovascular Research (1969)

Progressive narrowing of the left circumflex coronary artery, leading to complete occlusion within about 3 weeks, was produced in dogs by the ameroid technique. The development of intercoronary anastomoses by growth of pre-existing channels of arteriolar size was studied on the cytological, histological, histochemical, and arteriographic level. Several characteristic stages in the transformation of a small arteriole into a small artery are described.
Phase I/II study of gemtuzumab ozogamicin added to fludarabine, melphalan and allogeneic hematopoietic stem cell transplantation for high-risk CD33 positive myeloid leukemias and myelodysplastic syndrome
Authors: M de Lima, R E Champlin, P F Thall, X Wang, T G Martin, J D Cook, G McCormick, M Qazilbash, P Kebriaei, D Couriel, E J Shpall, I Khouri, P Anderlini, C Hosing, K W Chan, B S Andersson, P A Patah, Z Caldera, E Jabbour, S Giralt
Journal: Leukemia (2007)
Doxorubicin Plus Sorafenib in Treatment of Advanced Hepatocellular Carcinoma
Authors: Robert A. Pazo Cid
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antistreptococcus Serum in Pulmonary Tuberculosis
Authors: T. Campbell
Journal: BMJ (1900)

OCT. 20, 1900I usually quite willing to give himself a fair chance of recovery.So far as I can judge, the treatment is more efficacious if begun early; if delayed beyond a certain time it is of no use, at any rate in the case of adults.In childhood it has seemed to me that the restorative power is greater.I have Eeen a few cases of restoration of a damaged heart when no treatment but rest was adopted, and even one or two in the absence of a sufficient amount of rest, but my experience tells me these cases are few.Among children rheumatism is not infrequently devoid of pain.A sore throat, a little fever, some aching in limbs, perhaps a few largish spots on the skin, may be all that indicates an attack of rheumatism which, if unobserved, may leave the heart crippled.I advise you to examine the heart carefully in all such cases.Lastly, two brief cautions: If your patient's heart after rheumatic endocarditis appears to have become normal under treatment, warn him to avoid active or violent exertion for two or three months, and also to take every precaution against another attack of rheumatism.If that recurs within three months, the heart is almost certain to be again involved.
TCT-718 Statin Is More Effective in Acute Myocardial Infarction Patients Presenting Atrial Fibrillation with High Level of High Sensitivity C-Reactive Protein Than Those with Low Level
Authors: Hae Chang Jeong, Youngkeun Ahn, Jae Yeong Cho, Sang Cheol Cho, Su Young Jang, Ji Eun Song, Jong Hyun Yoo, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Shung Chull Chae, Jei Keon Chae, Myeong Chan Cho, Young Jo Kim, Chong Jin Kim
Journal: Journal of the American College of Cardiology (2012)
An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB
Authors: Junxia Min, Alexander Zaslavsky, Giuseppe Fedele, Sara K McLaughlin, Elizabeth E Reczek, Thomas De Raedt, Isil Guney, David E Strochlic, Laura E MacConaill, Rameen Beroukhim, Roderick T Bronson, Sandra Ryeom, William C Hahn, Massimo Loda, Karen Cichowski
Journal: Nature Medicine (2010)
Load-Induced Transcriptional Activation of c- <i>jun</i> in Rat Myocardium
Authors: Wilson Nadruz, Claudia B. Kobarg, Sábata S. Constancio, Patrícia D.C. Corat, Kleber G. Franchini
Journal: Circulation Research (2003)

The increased expression of immediate-early genes is a key feature of the myocardial response to hypertrophic stimuli. In this study, we investigated whether pressure overload or phenylephrine treatment stimulated myocyte enhancer factor 2 (MEF2)-dependent transcriptional activation of c- jun in cardiac myocytes. Western blotting and immunohistochemical analysis of rat myocardium demonstrated that p70 MEF2 is highly expressed in the rat heart and is predominantly located at the nuclei of cardiac myocytes. Electrophoretic mobility shift assays of myocardial nuclear extracts revealed a consistent DNA binding activation of MEF2 after 1 and 2 hours of pressure overload. We further showed that pressure overload induced a progressive nuclear translocation and activation of extracellular signal–regulated kinase 5 (ERK5). Coimmunoprecipitation and in vitro kinase assays indicated that the activation of ERK5 was paralleled by increased association of ERK5/p70 MEF2 and by enhanced ability of ERK5 to phosphorylate p70 MEF2 . Experiments with in vivo transfection of the left ventricle with the c- jun promoter reporter gene showed that pressure overload induced a consistent increase of c- jun transcriptional activity in the rat myocardium. Rendering the MEF2 site of the c- jun plasmid inactive by mutation abolished the load-induced activation of the c- jun promoter reporter gene. Mutation of the MEF2 site also abolished the phenylephrine-induced c- jun promoter activation in neonatal rat ventricular myocytes. In addition, we demonstrated that neonatal rat ventricular myocyte transfection with ERK5-antisense oligodeoxynucleotide inhibited the phenylephrine-induced c- jun promoter activation. These findings identify MEF2 as a potential regulator of c- jun transactivation and suggest that ERK5 might be an important mediator of MEF2 and c- jun promoter activation in response to hypertrophic stimuli in cardiac myocytes.
SHORT- AND LONG-TERM OUTCOMES OF ELECTROLYSIS PERCUTANEOUS INTRATISSUE (EPI) IN CHRONIC LATERAL ELBOW EPICONDYLITIS
Authors: F Valera-Garrido, F Minaya-Muñoz, J M Sánchez-Ibáñez, F Medina-Mirapeix, F Polidori
Journal: British Journal of Sports Medicine (2013)

Introduction Chronic lateral elbow epicondylitis is a tendinosis with angiofibroblastic degeneration of the wrist extensors' origin. Electrolysis Percutaneous Intratissue (EPI) is a minimally invasive technique that involves the application of a galvanic current with an acupuncture needle in the soft tissue to initiate a local inflammatory process allowing phagocytosis and repair of the affected tissue. The aim of the study was evaluate the effectiveness of the EPI in chronic epicondylitis lateral. Methods Design: Cases series. Setting. MVClinic Physiotherapy. Subjects: Inclusion criteria were clinically diagnosed lateral epicondylitis (based on symptoms, site of tenderness, and pain elicited with resisted active extension of the wrist in pronation and elbow extension), onset of symptoms (equal to or more than 3 months), no previous local injections (eg. cortisone), no cervicoarthrosis C5–C6, no rheumatic disorder, no history of trauma, and no signs of posterior interosseous nerve entrapment. Outcome measures. Sonographic assessment, pain was evaluated using a visual analogue scale (VAS), algometry, and functional status was evaluated by completion of the DASH and Cozen´s test and Thomson´s test which were recorded at base line and at the end of treatment, at 6w and 6m post-treatment. Intervention. All patients received Electrolysis Percutaneous Intratissue (EPI)-one treatment session per week. At home, a simple programme of stretching and eccentric loading exercises to be performed on an individual basis twice every day. No cortisone or non-steroidal anti-inflammatories were prescribed during follow-up. For pain relief only, oral paracetamol and ice therapy were used. Results 36 subjects were included in the study, 52.8% men (47.2% women) with a mean age of 38 years. 80.5% of subjects reached a complete response after four sessions of EPI with a VAS&lt;2, 86.2% negative Cozen´s test and Thomson´s test, and algometry values changed very significantly from 7.9 kg of pressure on the lateral epicondyle to 29.3 kg. DASH questionnaire showed significant changes, the mean score in the total of 36 subjects was 37.4 points, which means that there was an improvement of over 40% in functional capacity. Sonographic assessment showed change in the structure of the tendon, or hypoechoic region (long term outcomes, no short outcomes) and neovascularization (short outcomes). Discussion The combined programme of EPI, more eccentric exercise and stretching is an effective treatment for chronic elbow lateral epicondylitis. Limitations of the study. The main limitation is the absence of a control group to compare the results obtained with a placebo or another intervention. In scientific literature, there are no similar studies as the technique has been recently developed. The next step is to launch a pilot study to validate the results.
Effects of vasopressin on the intravariceal pressure in patients with cirrhosis: Comparison with the effects on portal pressure
Authors: Jaime Bosch, Josep M. Bordas, Ricardo Mastai, David Kravetz, Miquel Navasa, Jaime Chesta, Pilar M. Pizcueta, Juan C. García-Pagán, Joan Rodés
Journal: Hepatology (1988)

The present study investigated to what extent measurements of wedged and free hepatic venous pressures adequately reflect the effects of vasopressin at the esophageal varices in patients with cirrhosis. Eleven patients undergoing therapeutic sclerotherapy were studied by measuring wedged hepatic venous pressure, intravariceal pressure, free hepatic venous pressure, superior vena cava pressure and the intravascular pressure gradients wedged hepatic venous pressure-free hepatic venous pressure and intravariceal pressure-superior vena cava pressure, prior to and after vasopressin injection (1 IU, iv). Vasopressin caused a significant reduction in intravariceal pressure (from 22.5 ± 9.4 to 19.2 ± 8.4 mm Hg, p &lt; 0.001). Measurement of wedged hepatic venous pressure and free hepatic venous pressure closely reflected the reduction in variceal pressure. Thus, wedged hepatic venous pressure decreased by 16 ± 11%, which is close to the 14 ± 7% change in intravariceal pressure, and the 23 ± 12% fall in the pressure gradient wedged hepatic venous pressure-free hepatic venous pressure was mirrored by the 26 ± 10% change in intravariceal pressure-superior vena cava pressure. These pressure gradients decreased more than the absolute pressures (intravariceal pressure and wedged hepatic venous pressure) due to concomitant increases in superior vena cava pressure (1.9 ± 1.9 mm Hg) and free hepatic venous pressure (0.6 ± 1.9 mm Hg). Since variceal wall tension, a parameter influencing the risk and severity of variceal bleeding, is modified by changes in intravariceal pressure but not by changes in superior vena cava pressure, our data suggest that the favorable effect of vasopressin is best indicated by the moderate fall in intravariceal pressure than by the greater reductions in the intravascular pressure gradients. This might explain the somehow deceiving results of vasopressin therapy for variceal hemorrhage. In addition, the study shows that the simple and safe technique of hepatic vein catheterization adequately reflects the effects of vasopressin on variceal pressure.
Long-term self-administered subcutaneous heparin in pregnancy.
Authors: G Spearing, I Fraser, G Turner, G Dixon
Journal: BMJ (1978)

FVC % in all our subjects.4Fortunately, the ventilatory impairment is of little clinical importance but it offers the clinician an objective assessment of progress: the absence of any improvement in the first week makes it unlikely that treatment is effective, thereby saving time and allowing exploration of alternative therapeutic approaches.