tbuckley/cabot-search huggingface dataset:
Abstract 4018: DNA methylation controls CHST11 gene expression in breast cancer
Authors: Damir Herman, Tatiana I. Leakey, Fariba Jousheghany, Aiwei yao-Borengasser, Craig A. Cooney, Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi
Journal: Cancer Research (2012)

Abstract Introduction: We have previously demonstrated that chondroitin sulfates (CS) play a crucial role in metastatic potential of breast cancer cells. We have shown that the expression level of carbohydrate (chondroitin 4) sulfotransferase-11 (CHST11) correlates with CS-A expression and aggressiveness of human breast cancer cells. The current study was mainly performed to determine whether the expression of CHST11 gene in breast cancer cells is controlled by DNA methylation. Methods: Quantitative real-time PCR was used to detect the expression of CHST11 in human breast cancer cell lines. MCF7 cells were treated with 5-aza-2′-deoxycytidine (5AzadC) for DNA demethylation and expression analysis. Methylation in MCF7, MDA-MB-231 cells and patient breast cancer specimens was analyzed using bisulfite genomic sequencing (BGS). Reduced representation bisulfite sequencing (RRBS) was performed in the CpG island of CHST11 with a minimum coverage of 10. Digital gene expression was used to estimate the number of transcribed copies of the CHST11 gene from the second-generation mRNA-sequencing data. Results: Treatment of MCF7 cells with 5-AzadC increased the expression of CHST11 and its product CS-A in a dose-dependent manner. We observed very low levels of DNA methylation in a CpG island of CHST11 in estrogen receptor-negative basal-like cell lines MDA-MB-231, MDA-MB-468, and BT-20, but very high levels in the same region in estrogen receptor-positive luminal MCF7, ZR-75-1, and T47-D cells. We found that the CpG island can also be hypomethylated in triple negative (negative for estrogen and progesterone receptors and Her2/neu) patient breast cancer tissues. Conclusions: The data suggest that DNA hypomethylation significantly contributes to CHST11 and surface CS-A expression in aggressive breast cancer cells. The data suggest that therapeutic use of DNA demethylating agents may promote more aggressive forms of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4018. doi:1538-7445.AM2012-4018
Response to Comment on: Chakera et al. Antenatal Diagnosis of Fetal Genotype Determines if Maternal Hyperglycemia due to a Glucokinase Mutation Requires Treatment. Diabetes Care 2012;35:1832–1834
Authors: Ali J. Chakera, Victoria L. Carleton, Beverley Shields, Glynis P. Ross, Andrew T. Hattersley
Journal: Diabetes Care (2012)

We appreciate the comments by Tartaglia et al. (1) in response to our study. We agree with Tartaglia et al. that maternal glucose management in glucokinase ( GCK ) pregnancy should be guided by knowledge of whether the fetus has inherited the mutation from the mother. In our article (2), we propose that fetal genetic testing should be performed if chorionic villus sampling (CVS) or amniocentesis is performed for …
Prenatal PCB-153 Exposure and Decreased Birth Weight: The Role of Gestational Weight Gain
Authors: Eva Govarts, Maribel Casas, Greet Schoeters, Merete Eggesbø, Damaskini Valvi, Mark Nieuwenhuijsen, Jens Peter Bonde, CHICOS Consortia
Journal: Environmental Health Perspectives (2014)

Verner et al. (2013) recently questioned whether the association between cord levels of PCB-153 (poly chlorinated biphenyl-153) and birth weight reported in our recent metaanalysis (Govarts et al. 2012) might be attributable to the influence of gestational weight gain (GWG), a factor that may be related to both PCB-153 concentrations and birth weight.By using simulated data in a physiologically based pharmaco kinetic (PBPK) model, Verner et al. (2013) concluded thatThe association between prenatal levels of PCBs and birth weight may be strongly confounded by the effect of [GWG] on both blood PCB levels and birth weight.
Increasing Choices for HIV Therapy
Authors: Scott M Hammer
Journal: New England Journal of Medicine (2002)

The field of antiretroviral therapy has witnessed remarkable progress during the past 15 years. There are now 16 approved therapeutic agents for infection with the human immunodeficiency virus (HIV), a pathogen that once caused nearly uniformly fatal illness. These agents target two essential enzymes of the virus, the reverse transcriptase and the protease (see Figure). The era of potent antiretroviral therapy, also termed highly active antiretroviral therapy, began in 1996 and has been marked by dramatic declines in morbidity and mortality due to HIV disease in the developed world. These advances have not been without their cost in terms of . . .
P75117β-Oestradiol activates oestrogen receptors in a sex-specific manner in rat cardiac fibroblasts leading to sex dimorphic collagen I and III expression
Authors: E Dworatzek, S Mahmoodzadeh, S Kunze, V Regitz-Zagrosek
Journal: Cardiovascular Research (2014)

Purpose: Female pressure-overloaded hearts show less collagen I and III gene expression and cardiac fibrosis, compared to males. This suggests an inhibitory effect of 17β-Oestradiol (E2) on collagens. Since E2 mediates its effect mainly via activation of its receptors, oestrogen receptor (ER) alpha (α) and beta (β), we analysed here the ER-mediated effects on collagen I and III expression in isolated rat cardiac fibroblasts from both sexes.
968 GENOTYPIC CHARACTERISATION OF HCV NS5B FOLLOWING 8-DAY MONOTHERAPY WITH THE POLYMERASE INHIBITOR PF-00868554 IN HCV-INFECTED SUBJECTS
Authors: P. Troke, M. Lewis, P. Simpson, E. van der Ryst, J. Hammond, C. Craig, M. Perros, M. Westby
Journal: Journal of Hepatology (2009)
Five-Year Outcome in Patients With Isolated Proximal Left Anterior Descending Coronary Artery Stenosis Treated by Angioplasty or Left Internal Mammary Artery Grafting
Authors: Jean-Jacques Goy, Eric Eeckhout, Christel Moret, Bernard Burnand, Pierre Vogt, Jean-Chrisophe Stauffer, Michel Hurni, Frank Stumpe, Patrick Ruchat, Ludwig von Segesser, Philip Urban, Lukas Kappenberger
Journal: Circulation (1999)

Background —Percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass surgery (CABG) improve the clinical status of patients with isolated proximal left anterior descending coronary artery stenosis. At 2 years, only additional revascularization was more frequently required after PTCA. Methods and Results —We monitored 134 patients randomized to PTCA (n=68) or CABG (n=66) for ≤5 years. End points were death, myocardial infarction, need for additional revascularization, clinical status, and medical treatment. At 5 years, 6 patients (9%) had died in the PTCA group versus 2 (3%) in the CABG group ( P =0.12). One patient in each group died of a cardiac cause. Myocardial infarction was more frequent after PTCA (15% versus 4%; P =0.0001), but Q-wave infarction was not (6% in the PTCA group versus 3% in the CABG group; P =0.8). Additional revascularization was required in 38% of patients in the PTCA group versus 9% in the CABG group ( P =0.0001). Functional status was comparable, with 6% of patients after PTCA and 3% after CABG in functional class III or IV. Finally, after PTCA or CABG, 62% and 91% of patients, respectively, were free of events ( P =0.0001). Conclusions —The 5-year prognosis of patients with isolated proximal left anterior descending coronary artery stenosis is good. Both PTCA and CABG improve clinical status, but revascularization was needed more frequently after PTCA. There is an excess incidence of non–Q-wave myocardial infarction in the PTCA group that does not affect the vital or symptomatic outcome.
Medical Revolution in Minnesota: A History of the University of Minnesota Medical School
Authors: Ronald L. Numbers
Journal: JAMA (1990)

Formal medical education at the University of Minnesota began a century ago with the opening of a joint allopathic-homeopathic Department of Medicine. Two decades later, when Abraham Flexner visited the campus as part of his inspection of medical schools in North America, he found a thriving institution already possessing "excellent, exceedingly attractive, and well organized" scientific facilities and planning in the near future to build a modern teaching hospital. In his landmark report in 1910 he congratulated Minnesota for being the "first state in the Union that may fairly be considered to have solved the most perplexing problems connected with medical education and practice" (quoted by Wilson, p 129). After a lean period following World War I, the medical school emerged in the 1930s as a world leader in abdominal surgery. Later, its clinical faculty pioneered in the development of cardiac surgery and in human organ transplantation, as well as
Preparation and optimization of various parameters of enteric coated pellets using the Taguchi L9 orthogonal array design and their characterization
Authors: D. Shravani, P.K. Lakshmi, J. Balasubramaniam
Journal: Acta Pharmaceutica Sinica B (2011)

Duloxetine hydrochloride enteric coated pellets were formulated using fluidized bed. Three separate layers, the drug layer, the barrier layer, and the enteric layer, were coated onto the inert core pellets. The pellets were optimized with the acid resistance and drug release in simulated intestinal fluid as the process parameters, using the Taguchi L9 orthogonal array. Various other properties, such as surface morphology, bulk and tapped density, Hausner's ratio, hardness, friability, yield of pellets, moisture content, and particle size distribution, were also studied in the optimized pellets. The concentration of the enteric polymer played a vital role in acid resistance, while the type of enteric polymer affected the drug release in simulated intestinal fluid. In both cases, it was determined that binder polymer concentration was not affected much. The comparisons between the optimized pellets and a market formulation yielded f1 and f2 values within a range of 4–5 and 60–65, respectively. Three month stability studies, conducted at accelerated conditions, showed the optimized pellets to be stable. Taguchi plays an important role in optimizing parameters, and optimization of duloxetine hydrochloride can be achieved with minimal trials.
When Walking Fails-Reply
Authors: Lisa I. Iezzoni
Journal: JAMA (1997)

<h3>In Reply.</h3> —I completely agree with Drs Gordan and Frank. Referrals to physiatrists could provide invaluable assistance to persons experiencing difficulty walking. As noted in my article, primary care physicians typically do not have specialized knowledge in this area. Therefore, establishing clear lines of referral between primary care physicians and physiatrists is essential. Primary care physicians should talk with local physical medicine specialists, learn from them about referral timing, clinical expectations, service options, and costs to patients, and develop communication channels to share care of patients. Recent discussions with physiatrist colleagues suggest 4 additional points. First, just as in other clinical disciplines, some physiatrists develop special areas of expertise: not all physiatrists feel equally comfortable advising patients about wheelchair options. Second, finding an appropriate physiatrist is not always easy. Even some big, inner-city, acute care hospitals do not have physiatrists on staff; physiatrists may be concentrated in rehabilitation facilities, places that primary
THE EFFICACY OF COMPREHENSIVE WARM-UP PROGRAM IN MALE ADOLESCENT FOOTBALL PLAYERS
Authors: Y Saho, K Haruyasu, C Nakahori, T Matsuda, S Nakajo, M Shimada, T Kobayashi, T Fukubayashi
Journal: British Journal of Sports Medicine (2014)

Background FIFA 11+ program has been shown to reduce injury risk in female football players but has not been evaluated in an Asian male adolescent players. Objective To investigate the effects of the FIFA 11 + on injury risk in a Japanese male adolescent football players. Design Cohort study. Setting 6 Japanese U-18 (age: 16–18) and U-15 (age: 13–15) football teams followed for three seasons (2010, 2011 and 2012). The 2010 season, players completed the usual warm-up as control group, whereas the 2011 and 2011 players performed the FIFA 11+ throughout the entire season as intervention group. Participants A total 986 male athletes (age: 12–18 years). Interventions FIFA 11+program was conducted twice a week or more in entire season in 2010 and 2011. Main outcome measurements Injury rate during football (match and training), match and training were reported as the number of injuries per 1000 player-hours. Results The injury rate during football, match, and training in the control season were 4.0, 8.9, and 3.4 injuries per 1000 player-hours and 2.0, 4.4, and 1.5 injuries per 1000 player-hours in the intervention season. The intervention season had reductions in relative risk (RR) of game of 29% (RR=0.71, 95% confidence interval (CI)=0.664 −0.747), of match of 46% (RR=0.54, 95% CI=0.477–0.611), and of training of 28% (RR=0.72, 95% CI=0.674–0.768). The injury rate of lower extremity was reduced significantly in intervention season compared with control season. Conclusions The FIFA 11+ program reduced overall injury risk and lower extremity injury risk in a Japanese male adolescent football players.
Consequences of basing ethical judgments on heuristics
Authors: R. O. Lindsay, Barbara Gorayska
Journal: Behavioral and Brain Sciences (1996)

Abstract Baron assumes that ethical decision-making can be evaluated without specifying more general features of the cognitive system within which it occurs. It is suggested that ethical principles are heuristics employed during goal-oriented action planning. Heuristics are bound to generate suboptimal decisions in some cases. It is rational to replace a particular heuristic only when the cost of associated error exceeds the cost of constructing and installing a more successful alternative.
Expression of the Androgen-Regulated Fusion Gene TMPRSS2-ERG Does Not Predict Response to Endocrine Treatment in Hormone-Naïve, Node-Positive Prostate Cancer
Authors: Joost L. Boormans, Karin G. Hermans, Angelique C.J. Ziel-van der Made, Geert J.H.L. van Leenders, Mark F. Wildhagen, Laurence Collette, Fritz H. Schröder, Jan Trapman, Paul C.M.S. Verhagen
Journal: European Urology (2009)
Cardiopulmonary Bypass: Principles and Practice
Authors: Colleen G. Koch
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME EXPERIMENTS ON THE VOLATILISATION AND ABSORPTION OF MERCURY
Authors: C. E. JENKINS
Journal: British Journal of Dermatology (1921)

Journal Article SOME EXPERIMENTS ON THE VOLATILISATION AND ABSORPTION OF MERCURY Get access C. E. JENKINS, M. R. C. S., L.R.C.P. C. E. JENKINS, M. R. C. S., L.R.C.P. Pathologist to Stalford Royal Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 33, Issue 4, 1 April 1921, Pages 135–138, https://doi.org/10.1111/j.1365-2133.1921.tb12398.x Published: 01 April 1921
Chronic anemia progressing to auer rod‐positive and TdT‐positive acute leukemia with 5q– chromosomal anomaly
Authors: Anita M. Xavier, Basil S. Kasimis
Journal: American Journal of Hematology (1984)

Abstract The 5q– syndrome is a recently described entity characterized by partial deletion of the long arm of chromosome No. 5 and by hematologic findings of chronic anemia with reticulocytopenia, nonlobulated megakaryocytes, and megathrombocytes. We report on a patient with the hematologic features of the 5q– syndrome who progressed to acute leukemia and whose uniqueness consisted of 1) lack of additional cytogenetic abnormalities, 2) presence of blasts with Auer rods, and 3) bone marrow cells positive for terminal deoxynucleotidyl transferase. His leukemia was refractory to conventional chemotherapy.
IMPACT OF PITAVASTATIN ON DEVELOPMENT OF NEW-ONSET DIABETES MELLITUS IN ASIAN POPULATION: THREE-YEAR CLINICAL FOLLOW UP RESULTS
Authors: Yoonjee Park, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, akkala goud, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Experimental autoimmune myocarditis in the guinea pig
Authors: J. D HOSENPUD, S. M CAMPBELL, M. V HART, M. S PAUL, J. R ROWLES, N. R NILES
Journal: Cardiovascular Research (1985)

Male and female guinea pigs underwent immunisation with heterologous heart protein (rat heart), complete Freund's adjuvant and pertussis vaccine (immunised) or normal saline (control) at weekly intervals for 6 weeks, and were subsequently studied. In vivo intracardiac pressures, cardiac outputs, blood volumes, in vitro pressure-volume relations, left ventricular collagen contents, light microscopy, direct immunofluorescence, lymphocyte stimulation studies, and serology for circulating anti heart antibody (haemagglutination and radioimmunoassay) were performed. Immunised guinea pigs studied between 5 and 8 weeks following the immunisation protocol demonstrated a 44% increase in LVEDP (p<0.005), an increase in right atrial pressure (p<0.001), although no change in aortic pressure or cardiac output when compared with controls. Left ventricular weight was increased 20% (p<0.001), and in vitro left ventricular volume by 34% (at 8 mmHg distending pressure, p<0.001). Lung wet weight was increased 44% (p<0.005), and left ventricular collagen content increased 60% (p<0.001). Cultured lymphocytes from treated guinea pigs demonstrated a 1.5- to 4.5-fold (dependent upon proximity to last immunisation) increase in radiolabeled thymidine uptake when incubated with guinea pig heart protein compared to controls (p<0.001), and circulating anti guinea pig heart antibodies were detected by haemagglutination and radioimmunoassay. Histological examination of the left ventricles revealed inflammatory cell infilltration and myocyte increase to varying degrees in 15 of the 18 treated animals. We conclude that inflammatory, probably immune-mediated, chronic myocarditis can be produced in the guinea pig.
An Introduction To The Study Of Hypnotism, Experimental And Therapeutic.
Authors: H. E. Wingfield
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Foreign Bodies in the Respiratory Tract
Authors: John R. Richardson
Journal: New England Journal of Medicine (1946)

WHEN the diagnosis of foreign body in the respiratory tract has been established by history, physical examination and x-ray study, the surgeon is presented with a problem whose successful solution consists, of course, in the extraction of the foreign body without harm or damage to the patient. Usually, it is the general practitioner who first sees such a patient, and thus the family physician has the first opportunity to make or to miss the diagnosis. Certain pitfalls must be avoided to prevent diagnostic error and improper attempts at removal. This paper briefly reviews some of the salient features of foreign . . .
Eccrine syringofibroadenoma. Report of a case and immunohistochemical study of keratin expression
Authors: T. OHNISHI, T. SUZUKI, S. WATANABE
Journal: British Journal of Dermatology (1995)

We report a 49-year-old woman with an eccrine syringofibroadenoma. An asymptomatic nodule appeared on the right heel, and subsequently enlarged gradually. Histological examination revealed anastomosing strands of pale epithelial cells, with occasional duct formation and mucinous fibrovascular stroma. There were two types of strands: thick and thin. Immunohistochemical study, using a panel of monoclonal antikeratin antibodies, revealed that the immunoreactivity differed between the two types of strands. The thick strands showed a staining pattern similar to the uppermost portion of the intradermal duct, and the thin strands showed a pattern similar to the other portion of the duct. This observation suggests that the thick and thin strands differentiate towards the uppermost portion and the remainder of the duct, respectively.
Getting a patient's consent for publication
Authors: F. Godlee
Journal: BMJ (2008)

The need to ask patients for consent before publishing their details in journals and elsewhere is well established. The BMJ ’s policy on this has been in place, with minor variations, for more than 10 years (http://resources.bmj.com/bmj/authors/editorial-policies/copy\_of\_patient-confidentiality)

Yet we still receive articles that don’t have patient consent. To our surprise some authors don’t seem to have thought about it at all, but occasionally authors tell us that they can’t get consent for various reasons. We then enter murky and sometimes stormy waters, navigated with the help of the BMJ ’s ethics committee. Is the case is of sufficient public …