Severe Metabolic Acidosis Associated with Nalidixic Acid Overdose
Authors: HAROLD DASH
Journal: Annals of Internal Medicine (1976)

Letters1 May 1976Severe Metabolic Acidosis Associated with Nalidixic Acid OverdoseHAROLD DASH, M.D., JOHN MILLS, M.D.HAROLD DASH, M.D.Search for more papers by this author, JOHN MILLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-5-570 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe report an adult in whom severe metabolic acidosis without cardiovascular collapse developed after an overdose of nalidixic acid. Simultaneous ingestion of probenecid may have accentuated the effect of ingested nalidixic acid by prolonging its serum half-life.An 18-year-old man, previously in good health, was admitted to San Francisco General Hospital on 21 April 1975 after ingestion of unknown quantities of nalidixic acid, probenecid, ethanol, Bellergal® tablets (phenobarbital 20 mg, ergotamine tartrate 0.3 mg, and belladonna 0.1 mg), propoxyphene hydrochloride capsules, and Combid® capsules (compazine 10 mg and isopropamide 5 mg).Physical examination on admission showed a man with Kussmaul's...References1. SHARGELKOSSCRAIN LRA: Nalidixic acid and hydroxynalidixic acid analysis in human plasma and urine by liquid chromatography. J Pharm Sci 62:1452-1454, 1973 CrossrefMedlineGoogle Scholar2. CAUBEAUDOINGJAILLARD GAM: A propos de trois cas d'intoxication aigue du nourrison par un nouvel antibacterien l'acide nalidixique. Urgence Med Chir 3:649-653, 1966 Google Scholar3. MARTINBABINDEMARQUEZ MJJ: Acidose métabolique sévère au cours d'un traitement par l'acide nalidixique chez un nouveau-né. Bordeaux Méd 2:1477-1478, 1969 Google Scholar4. GOTH A: Medical Pharmacology. 7th ed. St. Louis, C.V. Mosby Co., 1974, p. 474 Google Scholar5. BARZABRUSCHBERGERON MJM: Extraction of antibiotics from the circulation by liver and kidney: effect of probenecid. J Infect Dis 131 (suppl):86-97, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Service Divisions of Infectious Disease and Pulmonary Disease San Francisco General Hospital Departments of Medicine and Microbiology University of California San Francisco, CA 94110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCase Files of the University of California, San Francisco Medical Toxicology Fellowship: Seizures and a Persistent Anion Gap Metabolic AcidosisNalidixic Acid and Other Older QuinolonesAcid-Base Disorders Secondary to PoisoningLactic Acidosis: From Sour Milk to Septic ShockNMetabolic AcidosisNeurochemical Studies on Quinolone Antibiotics: Effects on Glutamate, GABA and Adenosine Systems in Mammalian CNSSerum electrolyte abnormalities caused by drugsDisorders associated with an altered anion gapLactic Acidosis, Hyperglycaemia and Convulsions following Nalidixic Acid OverdosageDrug Prescribing in Renal Failure: Dosing Guidelines for AdultsErythrocyte glycolysis: Stimulation by nalidixic acidDrug Therapy in Renal Failure: Dosing Guidelines for Adults Part I: Antimicrobial Agents, AnalgesicsWILLIAM M. BENNETT, M.D., RICHARD S. MUTHER, M.D., RICHARD A. PARKER, M.D., PETER FEIG, M.D., GAIL MORRISON, M.D., THOMAS A. GOLPER, M.D., IRWIN SINGER, M.D.Nalidixic Acid and Lactic AcidosisMetabolic acidosis and coma due to an overdose of nalidixic acidGuidelines for Drug Therapy in Renal FailureWILLIAM M. BENNETT, M.D., F.A.C.P., IRWIN SINGER, M.D., F.A.C.P., THOMAS GOLPER, M.D., PETER FEIG, M.D., CECIL J. COGGINS, M.D. 1 May 1976Volume 84, Issue 5Page: 570-571KeywordsAcidosisEthanolHalf lifeIngestion Issue Published: 1 May 1976 PDF DownloadLoading ...