tbuckley/cabot-search huggingface dataset:
Assessing Treatments with Cyclophosphamide
Authors: ALFRED D. STEINBERG
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 June 1983Assessing Treatments with CyclophosphamideALFRED D. STEINBERG, M.D.ALFRED D. STEINBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1026_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have followed with interest the increasing journal articles, book chapters, and books on the use of cyclophosphamide in the treatment of patients with nonmalignant diseases. Dr. Fauci has been a major contributor of articles urging the use of cyclophosphamide to treat these conditions on the basis of studies in series of patients. Such studies do not involve the comparison of cyclophosphamide treatment with alternative therapies; they do not even approach anything resembling a randomized trial. TheAnnalshas recently published yet another such paper (1). I feel compelled to point out the negative aspects of such...References1. FAUCI A, HAYNES B, KATZ P, and WOLFF S. Wegener's granulomatosis Ann Intern Med. 1983;98:76-85. LinkGoogle Scholar2. WOLFF S, FAUCI A, HORN R, and DALE D. Wegener's granulomatosis Ann Intern Med. 1974;81:513-25. LinkGoogle Scholar1. FAUCI A, HAYNES B, KATZ P, and WOLFF S. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98:76-85. LinkGoogle Scholar2. FAUCI A and WOLFF S. Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine (Baltimore). 1973;52:653-61. CrossrefGoogle Scholar3. WOLFF S, FAUCI A, HORN R, and DALE D. Wegener's granulomatosis. Ann Intern Med. 1974;81:513-25. LinkGoogle Scholar4. HOLLANDER D and MANNING R. The use of alkylating agents in the treatment of Wegener's granulomatosis. Ann Intern Med. 1967;67:393-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALFRED D. STEINBERG, M.D.Affiliations: Arthritis and Rheumatism Branch National Institutes of Health Bethesda, MD 20205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1983Volume 98, Issue 6 Page: 1026-1027 Keywords Cyclophosphamide Patients Randomized trials ePublished: 1 December 2008 Issue Published: 1 June 1983 PDF downloadLoading ...
The spontaneous occurrence of paroxysmal supraventricular tachycardia.
Authors: E L Pritchett, M S Smith, E A McCarthy, K L Lee
Journal: Circulation (1984)

The seemingly unpredictable occurrence of paroxysmal supraventricular tachycardia has impeded understanding of its clinical course. We documented recurring tachycardia by telephone transmission of the electrocardiogram in 14 patients and measured the "tachycardia-free periods" between the start of therapy and the first recurrence of tachycardia and between successive recurrences. We showed that attacks of tachycardia were clinically independent by calculating the autocorrelation function for 12 to 14 consecutive tachycardia-free periods. We also found that the periods between attacks closely fit an exponential probability distribution, indicating that the occurrence of tachycardia in time was a type of random event called a Poisson process. Furthermore, occurrence of tachycardia was uniformly distributed throughout a dosing interval; there was no predilection for tachycardia to occur late in a dosing interval when plasma drug levels were presumed to be lowest. Measuring the tachycardia-free period is a simple and useful method for objectively studying paroxysmal supraventricular tachycardia and may be applied to the study of other paroxysmal arrhythmias.
Epidemiologic and Molecular Investigation of Outbreaks of Hepatitis C Virus Infection on a Pediatric Oncology Service
Authors: Anders Widell
Journal: Annals of Internal Medicine (1999)

Background: Despite screening of blood donors, hepatitis C virus (HCV) infection can occur in patients who receive multiple transfusions. Objective: To clarify mechanisms of nosocomial transmission of HCV. Design: Epidemiologic and molecular analyses of hepatitis C outbreaks. Setting: Pediatric oncology ward. Patients: Children with cancer. Measurements: Epidemiologic analysis, HCV RNA detection, genotyping, and hypervariable region 1 (HVR1) sequencing. Results: Ten cases of infection with acute HCV genotype 3a occurred between 1990 and 1993. Sequencing of HVR1 revealed three related strains. Despite an overhaul of hygiene procedures, a patient infected with genotype 1b generated nine subsequent infected patients in 1994. Several patients had high virus titers and strongly delayed anti-HCV antibody responses. All had permanent intravenous catheters. Multidose vials used for flushing or treatment had probably been contaminated during periods of overlapping treatment. Conclusions: Contamination of multidose vials was the most likely mode of HCV transmission; therefore, use of such vials should be restricted. Rigorous adherence to hygiene routines remains essential to preventing transmission of bloodborne infections.
Hyperbaric oxygen induces vascular endothelial growth factor and reduces liver injury in regenerating rat liver after partial hepatectomy
Authors: Hideki Ijichi, Akinobu Taketomi, Tomoharu Yoshizumi, Hideaki Uchiyama, Yusuke Yonemura, Yuji Soejima, Mitsuo Shimada, Yoshihiko Maehara
Journal: Journal of Hepatology (2006)
The Appetite of Pregnant Women
Authors: Richard L. Landau
Journal: JAMA (1983)

Why do pregnant women eat more? On the surface, this is another of those biomedical questions that need not be asked. Simplistically, the answer is so obvious: baby, placenta, uterus, and breasts are growing. More protein, calories, and other nutrients are required for the growth. The nutrients for the growing transplant are transported actively and passively from the pregnant woman's circulating plasma. The real question then, is how does this growing tissue, most of it in a sense "outside" her body, result in an increased appetite? The normal pregnant woman does indeed have a positive energy balance. She eats more calories than she expends. When food is plentiful, many pregnant women not only consume enough during the pregnancy to compensate for the demands of the growing products of conception, but a surfeit, which results in a net storage of fat. Obstetricians sometimes need to caution and instruct pregnant women to
Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women
Authors: David Melzer, Nicholas J. Osborne, William E. Henley, Riccardo Cipelli, Anita Young, Cathryn Money, Paul McCormack, Robert Luben, Kay-Tee Khaw, Nicholas J. Wareham, Tamara S. Galloway
Journal: Circulation (2012)

Background— The endocrine-disrupting chemical bisphenol A (BPA) is widely used in food and beverage packaging. Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003–2004 and NHANES 2005–2006, independent of traditional risk factors. Methods and Results— We included 758 incident coronary artery disease (CAD) cases and 861 controls followed for 10.8 years from the European Prospective Investigation of Cancer–Norfolk UK. Respondents aged 40 to 74 years and free of CAD, stroke, or diabetes mellitus provided baseline spot urine samples. Urinary BPA concentrations (median value, 1.3 ng/mL) were low. Per-SD (4.56 ng/mL) increases in urinary BPA concentration were associated with incident CAD in age-, sex-, and urinary creatinine–adjusted models (n=1919; odds ratio=1.13; 95% confidence interval, 1.02–1.24; P =0.017). With CAD risk factor adjustment (including education, occupational social class, body mass index category, systolic blood pressure, lipid concentrations, and exercise), the estimate was similar but narrowly missed 2-sided significance (n=1744; odds ratio=1.11; 95% confidence interval, 1.00–1.23; P =0.058). Sensitivity analyses with the fully adjusted model, excluding those with early CAD (&lt;3-year follow-up), body mass index &gt;30, or abnormal renal function or with additional adjustment for vitamin C, C-reactive protein, or alcohol consumption, all produced similar estimates, and all showed associations at P ≤0.05. Conclusions— Associations between higher BPA exposure (reflected in higher urinary concentrations) and incident CAD during &gt;10 years of follow-up showed trends similar to previously reported cross-sectional findings in the more highly exposed NHANES respondents. Further work is needed to accurately estimate the prospective exposure-response curve and to establish the underlying mechanisms.
Expanding Access to Testicular Tissue Cryopreservation: An Analysis by Analogy
Authors: Tuua Ruutiainen, Steve Miller, Arthur Caplan, Jill P. Ginsberg
Journal: The American Journal of Bioethics (2013)

Researchers are developing a fertility preservation technique--testicular tissue cryopreservation (TTCP)--for prepubescent boys who may become infertile as a result of their cancer treatment. Although this technique is still in development, some researchers are calling for its widespread use. They argue that if boys do not bank their tissue now, they will be unable to benefit from any therapies that might be developed in the future. There are, however, risks involved with increasing access to an investigational procedure. This article examines four methods of expanding access to TTCP: (1) expansion of institutional review board (IRB)-approved research trials; (2) offering TTCP as an innovative procedure in hospitals; (3) offering TTCP as a standard practice in hospitals; and (4) commercialization of TTCP. The ethical and practical implications of each are evaluated through a comparison with umbilical cord blood banking (UCBB), a technology that has achieved widespread use based on similar claims of future benefit.
T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections
Authors: Carlo Ferrari, Antonietta Valli, Lucia Galati, Amalia Penna, Patrizia Scaccaglia, Tiziana Giuberti, Claudia Schianchi, Gabriale Missale, Maria Grazia Marin, Franco Fiaccadori
Journal: Hepatology (1994)

Twenty-nine patients with chronic hepatitis C and 15 asymptomatic hepatitis C virus antibody-positive subjects who clinically recovered from hepatitis C virus infection were studied for their peripheral blood lymphomononuclear cell proliferative response to hepatitis C virus structural and nonstructural antigens (core, envelope, nonstructural 4 and nonstructural 5) expressed in yeast as superoxide dismutase fusion proteins, in an initial attempt to define some of the features of the virus-specific immune response. Hepatitis C virus core was the most immunogenic antigen for human leukocyte antigen class II-restricted T cells in both groups of patients studied, and the proliferative response to it was the most vigorous and the most frequently expressed in comparison with the other antigens tested. The specificity of the results was supported by the lack of response to hepatitis C virus antigens by healthy uninfected controls and confirmed by recognition of recombinant core proteins of different origin (yeast and baculovirus) by polyclonal T-cell lines produced by T-cell stimulation with yeast-derived core. Each of the antigens tested was able to induce significant although variable levels of proliferative response, indicating that all can be immunogenic at the T-cell level. Significant proliferative responses to core, nonstructural 4 and nonstructural 5 antigens were more frequently detected in subjects who were able to eradicate infection than in patients with chronic hepatitis C, although the difference was statistically not significant. No difference was observed between the two groups of patients with respect to the response to the putative envelope antigens.
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.
Authors: Andrew J. Holland, Don W. Cleveland
Journal: Journal of Clinical Investigation (2012)

The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion®) in human bones
Authors: Akira Ogose, Naoki Kondo, Hajime Umezu, Tetsuo Hotta, Hiroyuki Kawashima, Kunihiko Tokunaga, Tomoyuki Ito, Naoko Kudo, Makiko Hoshino, Wenguang Gu
Journal: Biomaterials (2005)
Critical Function for SIP, a Ubiquitin E3 Ligase Component of the β-Catenin Degradation Pathway, for Thymocyte Development and G1 Checkpoint
Authors: Toru Fukushima, Juan M. Zapata, Netai C. Singha, Michael Thomas, Christina L. Kress, Maryla Krajewska, Stan Krajewski, Ze'ev Ronai, John C. Reed, Shu-ichi Matsuzawa
Journal: Immunity (2006)
Financial Incentives in Primary Care Practice
Authors: Rowena J. Dolor, Kevin A. Schulman
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psoriasis and Hemodialysis
Authors: JOSEPH MCEVOY
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 September 1978Psoriasis and HemodialysisJOSEPH MCEVOY, M.D.JOSEPH MCEVOY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-3-429_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As one author of the original paper describing psoriatic clearance during hemodialysis (MCEVOY J, KELLY AMT: Ulster Med J 45:76-78, 1976) I was most interested to read the paper by Twardowski and associates, "Peritoneal Dialysis for Psoriasis. An Uncontrolled Study" (Ann Intern Med 88:349-351, 1978). In the article it is stated, "Reported improvement of psoriasis during hemodialysis with the use of bicarbonate dialysis fluid suggests that a direct effect of acetate or lactate is unlikely (1, 6)."Reference 2 (TWARDOWSKIZJ: Abatement of psoriasis and repeated dialysis.Ann Intern Med86:509-510, 1977) contains no reference to the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine Division of Nephrology The Christ Hospital Cincinnati, OH 45219 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1978Volume 89, Issue 3Page: 429-430KeywordsBicarbonatesLactatesMedical dialysisPeritoneal dialysisPsoriasis Issue Published: 1 September 1978 PDF downloadLoading ...
Discovering the Individual
Authors: Zenonas Danilevicius
Journal: JAMA (1978)

Historians will probably call the 20th century an age of scientific progress and enlightenment. They will also call it the century that brought enormous disregard for human life, a century that will be remembered for its wars, rebellions, and subsequent loss of millions of innocent lives. All that is good in man has been accentuated, all that is creative in him has been awakened, but much that is bad in him has triumphed. What a paradox! Understandably, these events have caused many to regard man's future with some trepidation. Jean Hamburger,<sup>1</sup>however, does not share this fear. A pure scientist, teacher, pioneer in kidney transplantation, and prolific writer, he sees hope for mankind. In his new book,<i>Discovering the Individual</i>,<sup>1</sup>Hamburger presents a fascinating description of recent advances in immunology and genetics. From these he draws some philosophical conclusions concerning built-in or genetic possibilities for the action of
Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases
Authors: R M Linka, S L Risse, K Bienemann, M Werner, Y Linka, F Krux, C Synaeve, R Deenen, S Ginzel, R Dvorsky, M Gombert, A Halenius, R Hartig, M Helminen, A Fischer, P Stepensky, K Vettenranta, K Köhrer, M R Ahmadian, H-J Laws, B Fleckenstein, H Jumaa, S Latour, B Schraven, A Borkhardt
Journal: Leukemia (2012)
Abstract 2475: Pulmonary Vein Reconnection After Two or More Failed Atrial Fibrillation Ablations: Impact of the Operator Experience
Authors: Luigi Di Biase, J. David Burkhardt, Rodney Horton, Javier Sanchez, G. Joseph Gallinghouse, Shane Bailey, Prasant Mohanty, Dimpi Patel, Jennifer E. Cummings, Robert A. Schweikert, Steven Hao, Richard Hongo, Salwa Beheiry, Andrea Natale
Journal: Circulation (2009)

Introduction: Catheter ablation of atrial fibrillation (PVI) is an established treatment option for patients with symptomatic drug refractory atrial fibrillation. Although the procedural success is...
Financial Conflicts of Interest and Conclusions About Neuraminidase Inhibitors for Influenza
Authors: Adam G. Dunn, Diana Arachi, Joel Hudgins, Guy Tsafnat, Enrico Coiera, Florence T. Bourgeois
Journal: Annals of Internal Medicine (2014)

Industry funding and financial conflicts of interest may contribute to bias in the synthesis and interpretation of scientific evidence.To examine the association between financial conflicts of interest and characteristics of systematic reviews of neuraminidase inhibitors.Retrospective analysis.Reviews that examined the use of neuraminidase inhibitors in the prophylaxis or treatment of influenza, were published between January 2005 and May 2014, and used a systematic search protocol.Two investigators blinded to all information regarding the review authors independently assessed the presentation of evidence on the use of neuraminidase inhibitors as favorable or not favorable. Financial conflicts of interest were identified using the index reviews, other publications, and Web-based searches. Associations between financial conflicts of interest, favorability assessments, and presence of critical appraisals of evidence quality were analyzed.Twenty-six systematic reviews were identified, of which 13 examined prophylaxis and 24 examined treatment, accounting for 37 distinct assessments. Among assessments associated with a financial conflict of interest, 7 of 8 (88%) were classified as favorable, compared with 5 of 29 (17%) among those without a financial conflict of interest. Reviewers without financial conflicts of interest were more likely to include statements about the quality of the primary studies than those with financial conflicts of interest.The heterogeneity in populations and outcomes examined in the reviews precluded analysis of the contribution of selective inclusion of evidence on the discordance of the assessments made in the reviews. Many of the systematic reviews had overlapping authorship.Reviewers with financial conflicts of interest may be more likely to present evidence about neuraminidase inhibitors in a favorable manner and recommend the use of these drugs than reviewers without financial conflicts of interest.Australian National Health and Medical Research Council.
Nuclear Imaging in Coccidioidal Osteomyelitis
Authors: ALBERT J. MORENO, IDELLE M. WEISMAN, ANA A. RODRIGUEZ, CYNTHIA D. HENRY, GOTTLIEB L. TURNBULL
Journal: Clinical Nuclear Medicine (1987)

Six cases of osteomyelitis due to Coccidioides immitis are presented. The cases reported demonstrate the importance of performing both bone and gallium imaging to avoid missing the osseous coccidioidal lesions.
Independent Correlation Between Plasma Lipoprotein(a) and Angiographie Coronary Artery Disease in NIDDM
Authors: Gerald F Watts, Rhiannon M Ap Gwilym, Janina Mazurkiewicz, John Coltart
Journal: Diabetes Care (1995)

To examine the correlation between angiographic coronary artery disease (CAD) and plasma lipoprotein(a) [Lp(a)] concentration in non-insulin-dependent diabetes mellitus (NIDDM).In this cross-sectional study of 36 patients with NIDDM who underwent coronary angiography, CAD was assessed visually using a coronary artery score (CAS), and plasma Lp(a) was measured immunoturbidimetrically.Lp(a) concentration was significantly higher in patients in the middle and upper tertiles of CASs (> 4) compared with those in the lower tertile (< or = 4); geometric mean 0.30 g/l (95% confidence interval [CI] 0.22-0.40) vs. 0.12 g/l (0.08-0.17, P = 0.002). Lp(a) was significantly and positively correlated with the CAS (R2 23%, P = 0.006), independent of other cardiovascular risk factors, including lipoprotein related variables and glycated hemoglobin.Plasma Lp(a) is a strong and independent correlate of the extent of angiographic CAD in symptomatic patients with NIDDM.
UVA sunbeds: tanning, photoprotection, acute adverse effects and immunological changes
Authors: J.K. RIVERS, P.G. NORRIS, G.M. MURPHY, A.C. CHU, G. MIDGLEY, J. MORRIS, R.W. MORRIS, A.R. YOUNG, J.L.M. HAWK
Journal: British Journal of Dermatology (1989)

The effects on 31 normal subjects following exposure to sunbeds containing UVA lamps with minimal UVB emission have been compared in a double‐blind study with the effects on nine control subjects of a similar exposure course three times weekly for 4 weeks to sunbeds emitting visible light. On previously untanned areas, all those subjects on active treatment developed a mild tan; in tanned areas they all developed a moderate tan, while all control subjects developed a minimal to mild tan. The mean protection factor against later UVB‐induced erythema was 3.2±0.3 after the active course and 1.6±0.2 among the controls. Significantlsy more frequent adverse cutaneous effects for active subjects were pruritus, erythema, freckling, burning sensation, dryness and polymorphic light eruption. Cutaneous Langerhans cell numbers, and blood CD3+ (pan T‐cell) and CD4+ (helper T‐cell) lymphocyte subsets were reduced in both active and control groups. CD8+ (cytotoxic/suppressor T‐cell) counts were significantly reduced in both groups. The changes found in both groups seem attributable to small amounts of UVB emission from both active and control lamps.