tbuckley/cabot-search huggingface dataset:
Axial Osteomalacia: An Unusual Bone Syndrome.
Authors: B. Frame
Journal: Annals of Internal Medicine (1961)

s1 May 1961Axial Osteomalacia: An Unusual Bone Syndrome.B. Frame, M.D., (Assoc.), R. S. Ormond, M.D., H. M. Frost, M.D., R. B. Hunter, M.D.B. Frame, M.D., (Assoc.)Search for more papers by this author, R. S. Ormond, M.D.Search for more papers by this author, H. M. Frost, M.D.Search for more papers by this author, R. B. Hunter, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1043_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past year, four patients with unique coarsening and sponge-like appearance of the axial skeleton have been observed. Metabolic bone disease, as well as diffuse metastatic malignancy, was considered in the differential diagnosis. Studies of calcium and phosphorus metabolism revealed only minor and inconsistent abnormalities. Bone biopsies in three of the patients who were biopsied demonstrated wide osteoid seams and a marked increase in their number per unit volume, conditions compatible with osteomalacia.The term axial osteomalacia has been chosen to indicate that the condition appears to be confined to the axial skeleton. It is postulated that the syndrome... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: B. Frame, M.D., (Assoc.); R. S. Ormond, M.D.; H. M. Frost, M.D.; R. B. Hunter, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHyperlipidemic myeloma: review of 53 casesThe Cutaneous Plasma Cell DyscrasiasParaproteinämische HämoblastosenHyperlip�mie bei malignen ErkrankungenXANTHOMATOSIS IN CRYOGLOBULINAEMIA AND OTHER PARAPROTEINAEMIAS WITH REPORT OF A CASE*SKIN XANTHOMA FOLLOWING ERYTHRODERMAM-proteins, plasmacytosis and cancer 1 May 1961Volume 54, Issue 5 Page: 1043-1044 Keywords Biopsy Bone Calcium Metabolic disorders Phosphorus Skeleton ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Putting Me Out
Authors: Michele Wyrebek
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ability of Cyclohexenonic Long-Chain Fatty Alcohol to Reverse Diabetes-Induced Cystopathy in the Rat
Authors: Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Chiko Shinbori, Hiroto Suzuki, Masashi Yamada, Takeshi Watanabe, Keisuke Satoh
Journal: European Urology (2006)
Recurrent annular erythema associated with anti-SS-B/La antibodies: analysis of the disease-specific epitope
Authors: Y. HOSHINO, T. HASHIMOTO, T. MIMORI, M. AKIZUKI, T. NISHIKAWA
Journal: British Journal of Dermatology (1992)

We have found that anti-SS-B/La antibodies are present in a group of patients with a characteristic recurrent annular erythema, and immunological abnormalities. The presence of a disease-specific epitope for this entity has been examined by comparing immunological reactivity of anti-SS-B/La antibodies between these patients and patients with classical Sjögren's syndrome who have anti-SS-B/La antibodies but do not have this characteristic erythema. In immunoblotting using three different antigen sources, all the sera from both groups exhibited the same reaction patterns. V8 protease mapping showed that the sera could be divided into three groups by the difference in reactivity to two main digested peptide fragments. However, no significant relationship of the reactivity in peptide mapping between the two patient groups was observed. Further studies are necessary to elucidate the role of anti-SS-B/La antibodies in disease pathogenesis in these patients, in particular by more precise peptide mapping using recombinant SS-B/La antigen proteins.
Hysteria And Suicide
Authors: David Lester
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Woodruff et al<sup>1</sup>stated that a physician with a patient diagnosed as having hysteria need not be as concerned with the risk of suicide as when he has a patient diagnosed as having a primary affective disorder. Though suicidal attempts and suicidal threats are common in hysterics, completed suicide is rare. This conclusion is erroneous according to current data. Bibb and Guze<sup>2</sup>have reported that suicide attempts are equally common in hysterics and primary affective disorders (an incidence of 20% in each group), and suicidal threats appear to be more common in the hysterics (19% vs 11%). However, completed suicide is also equally common in hysterics and primary affective disorders. Guze<sup>3</sup>has reported that, in follow-up studies of patients diagnosed as hysterics (admittedly not utilizing the best criteria), some 16% of all deaths were from suicide. Similarly, Guze and Robins<sup>4</sup>have estimated that some
Cystic fibrosis in a 70 year old woman.
Authors: P van Biezen, S E Overbeek, C Hilvering
Journal: Thorax (1992)

A 68 year old woman with a lifelong history of chronic bronchitis was diagnosed as having cystic fibrosis. The diagnosis was based on a suggestive family history, steatorrhoea, bronchiectasis with respiratory insufficiency, and very high sweat sodium content. The patient was found to be heterozygous for the delta F 508 gene defect.
A Randomized Study of Maintenance Therapy with Ranitidine to Prevent the Recurrence of Duodenal Ulcer
Authors: Gary M. Van Deventer, Janet D. Elashoff, Terry J. Reedy, Daria Schneidman, John H. Walsh
Journal: New England Journal of Medicine (1989)

After an active duodenal ulcer has healed in response to medical therapy, the rate of recurrence during the subsequent year is relatively high. We therefore enrolled 140 patients with healed duodenal ulcers in a two-year randomized, double-blind trial comparing maintenance therapy (ranitidine, 150 mg nightly) with placebo for the prevention of recurrent duodenal ulceration. We performed endoscopy annually and when symptoms suggested the recurrence of ulcers. Verified recurrent ulcers in either group were treated for four or eight weeks with open-label ranitidine (150 mg twice a day). Patients whose ulcers healed within eight weeks resumed randomized treatment. Prophylactic therapy with ranitidine reduced the rate of ulcer relapses from 63 percent in the placebo group to 37 percent in the ranitidine group (P<0.05). Treatment with ranitidine extended the median ulcer-free interval from one to two years (P<0.05). The first recurrences of ulcer were asymptomatic in half the ranitidine group and in a quarter of the placebo group. Prophylactic therapy with ranitidine also reduced the frequency of recurrent ulcers that were unhealed by eight weeks, that were bleeding, that were in the stomach, or that were the second recurrent ulcer within six months, from 43 percent in the placebo group to 21 percent. Patients who drank alcohol, smoked, had a history of ulcer disease, or had duodenal scarring or erosion at the time of entry into the study were at the greatest risk for recurrence and benefited the most from prophylactic ranitidine. We conclude that prophylactic treatment with ranitidine is effective in preventing the recurrence of duodenal ulceration. (N Engl J Med 1989; 320:1113–9.)
Injury history as a risk factor for incident injury in youth soccer
Authors: K L Kucera, S W Marshall, D T Kirkendall, P M Marchak, W E Garrett
Journal: British Journal of Sports Medicine (2005)

To determine if athletes with a self reported history of previous injury have a higher incident injury rate than athletes without a self reported injury history.A prospective cohort study of Classic League soccer players playing at the level under 12 through under 18. Injury history forms were mailed to all registering Classic League soccer players in the North Carolina Youth Soccer Association during 1997-2000 (n = 7000); 1483 (19%) returned the baseline questionnaire and were followed up for injuries.There were 5139 player-seasons of follow up and an estimated 171 957 athlete-exposures. More than half self reported an injury history (59.7%). Overall, the unadjusted incidence rate was 4.6 (95% confidence interval (CI) 4.3 to 4.9) incident injuries per 1000 athlete-exposures. Multivariate generalised Poisson regression modelling indicated that players with one previous injury had a twofold greater risk of incident injury (IRR = 2.6; 95% CI 2.0 to 3.3), and those with two or more previous injuries had a threefold greater risk of incident injury (IRR = 3.0; 95% CI 2.3 to 3.8) compared with athletes with no previous injuries.Injury history was associated with an increased injury rate. This suggests that, even in these youth soccer players, those with an injury history may be at higher risk.
A randomized clinical trial comparing 22G and 25G needles in endoscopic ultrasound-guided fine-needle aspiration of solid lesions
Authors: L. Camellini, G. Carlinfante, F. Azzolini, V. Iori, M. Cavina, G. Sereni, F. Decembrino, C. Gallo, I. Tamagnini, R. Valli, S. Piana, C. Campari, G. Gardini, R. Sassatelli
Journal: Endoscopy (2011)

See also: Commentaire de travail de L. Camellini et al., pp. 709Endoscopy 2011; 43(08): 930-930DOI: 10.1055/s-0031-1291772
Lysosomes and Trivalent Arsenic Treatment in Acute Promyelocytic Leukemia
Authors: Sutisak Kitareewan, B. D. Roebuck, Eugene Demidenko, Roger D. Sloboda, Ethan Dmitrovsky
Journal: JNCI Journal of the National Cancer Institute (2007)

Background Cells from patients with t(15;17) acute promyelocytic leukemia (APL) express the fusion protein between the promyelocytic leukemia protein and retinoic acid receptor α (PML/RARα). Patients with APL respond to differentiation therapy with all- trans -retinoic acid, which induces PML/RARα degradation. When resistance to all- trans -retinoic acid develops, an effective treatment is arsenic trioxide (arsenite), which also induces this degradation. We investigated the mechanism of arsenite-induced PML/RARα degradation.
Risk of Sexually Transmitted Disease Among Black Adolescent Crack Users in Oakland and San Francisco, Calif
Authors: Robert E. Fullilove
Journal: JAMA (1990)

Crack cocaine is a smokable form of cocaine hydrochloride that has been associated with increases in crime, increases in admissions to drug treatment programs, and, recently, increases in the incidence of sexually transmitted diseases (STDs) among black teenagers. In an exploratory, cross-sectional study of the prevalence of risk behaviors that would promote the dissemination of STDs (including human immunodeficiency virus) among 222 black teenaged crack users, 41% of those interviewed reported a history of an STD. A history of an STD was more likely to be reported by girls (55%) than by boys (34%) and by those who combined crack use with sexual relations (51%) than those who did not (32%). The number of risk behaviors for STDs or human immunodeficiency virus reported by respondents (including failure to use a condom in one's most recent sexual encounter, having had a history of an STD, engaging in exchanges of sex for drugs or money, combining sexual activity with drug use, and reporting five or more sexual partners per year) was evaluated using multiple regression analysis stratified by gender. For girls, a history of selling crack and the number of drugs used on a daily basis were associated with the number of reported risk behaviors (<i>R</i>=.46); for boys who chose the description "I don't know ahead of time if I'm going to have sex—it just happens" and the number of drugs used on a daily basis were associated with the number of reported risk behaviors (<i>R</i>=.31). Because of the impetuous nature of some crack-related sexual activity and because 76% of respondents acknowledged that they were either "very worried" or "somewhat worried" that they might get acquired immunodeficiency syndrome, it is possible that a program of widespread distribution of condoms in neighborhoods where crack use is prevalent might make it possible for the worried, impulsive crack user to practice "safer sex." (<i>JAMA</i>. 1990;263:851-855)
Over-the-Counter Chromium and Renal Failure
Authors: John N. Hathcock
Journal: Annals of Internal Medicine (1997)

Letters15 October 1997Over-the-Counter Chromium and Renal FailureJohn N. Hathcock, PhDJohn N. Hathcock, PhDCouncil for Responsible Nutrition; Washington, DC 20036Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-8_Part_1-199710150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent letter by Wasser and colleagues [1] provides an incomplete interpretation of its subject. The letter clearly suggests that chromium picolinate was causally related to the renal failure. The authors gave serious consideration only to chromium picolinate as the possible etiologic agent and did not discuss other possibilities distinctly suggested by the facts presented.The authors dismissively state that “the only other medications [the patient] received were antihypertensive agents.” They provide no information about which antihypertensive agents were used, whether changes in medication were made during the period under consideration, or the degree to which the ...References1. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate [Letter]. Ann Intern Med. 1997; 126:410. Google Scholar Author, Article, and Disclosure InformationAffiliations: Council for Responsible Nutrition; Washington, DC 20036 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxicology of Chromium(III)The nutritional supplement chromium picolinate generates oxidative DNA damage and peroxidized lipids in vivoDrugs and nutrition 15 October 1997Volume 127, Issue 8_Part_1Page: 655 Issue Published: 15 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A systematic review of the role of C4d in the diagnosis of acute antibody-mediated rejection
Authors: Ruth Sapir-Pichhadze, Simon P. Curran, Rohan John, Andrea C. Tricco, Elizabeth Uleryk, Andreas Laupacis, Kathryn Tinckam, Banu Sis, Joseph Beyene, Alexander G. Logan, S Joseph Kim
Journal: Kidney International (2014)
Increasing the Dietary Potassium Intake Reduces the Need for Antihypertensive Medication
Authors: Alfonso Siani, Pasquale Strazzullo, Angela Giacco, Delia Pacioni, Egidio Celentano, Mario Mancini
Journal: Annals of Internal Medicine (1991)

Objective: To determine whether an increase in dietary potassium intake from natural foods reduces the need for antihypertensive medication in patients with essential hypertension. Design: Randomized, controlled trial with 1-year follow-up. Setting: Hypertension outpatient clinic of a university hospital. Patients: Fifty-four patients with well-controlled hypertension, 47 of whom completed 1 year of follow-up. Intervention: Patients were randomly assigned to one of two groups and were given dietary advice aimed at selectively increasing potassium intake (group 1) or at keeping their customary diet unchanged (group 2). During a 1-year follow-up period, drug therapy was reduced in stepwise fashion, according to a fixed protocol, provided that blood pressure remained below 160/95 mm Hg. Main Results: Potassium intake was checked monthly by referring to 3-day food records and by measuring 24-hour urinary potassium excretion. Potassium intake increased in group 1 but did not change in group 2 (P < 0.001). No change was observed in either urinary sodium excretion or in body weight. After 1 year, the average drug consumption (number of pills per day) relative to that at baseline was 24% in group 1 (95% Cl, 15% to 32%) and 60% in group 2 (Cl, 44% to 76%) (P < 0.001). By the end of the study, blood pressure could be controlled using less than 50% of the initial therapy in 81% of the patients in group 1 (Cl, 66% to 96%) compared with 29% of the patients in group 2 (Cl, 10% to 48%) (P = 0.001). Patients in group 1 ended the study with a lower number of reported symptoms compared with patients in the control group (P < 0.001). Conclusion: Increasing the dietary potassium intake from natural foods is a feasible and effective measure to reduce antihypertensive drug treatment.
Evaluation of health risks for contaminated aquifers.
Authors: W T Piver, T L Jacobs, M A Medina
Journal: Environmental Health Perspectives (1997)

This review focuses on progress in the development of transport models for heterogeneous contaminated aquifers, the use of predicted contaminant concentrations in groundwater for risk assessment for heterogeneous human populations, and the evaluation of aquifer remediation technologies. Major limitations and areas for continuing research for all methods presented in this review are identified.
EXPERIMENTAL SCARLET FEVER
Authors: GEORGE F. DICK
Journal: JAMA (1923)

A nurse who was taking care of a patient with scarlet fever acquired the disease in a mild but typical form. Two days before the onset of symptoms, she noticed that she had a sore finger. On the second day of the disease, when the rash was intense, a few drops of pus were obtained from the lesion on her finger. Gram, Giemsa and Levaditi stains were made of direct smears of this pus. They contained many polymorphonuclear leukocytes and numerous single and paired gram-positive cocci; also an occasional gram-positive diphtheroid bacillus. Cultures of the pus were made on the surface of freshly prepared sheep's blood agar plates. Anaerobic cultures were made in tubes of ascites broth which contained pieces of fresh rabbit kidney, and on human blood agar slants. Smears and dark field preparations of the anaerobic cultures were examined at frequent intervals during two weeks' incubation. No organisms
IMMUNOLOGICAL REACTIONS BETWEEN AGAR-AGAR AND SOME BACTERIAL ANTISERA
Authors: José Zozaya, Luis Medina
Journal: The Journal of Experimental Medicine (1933)

1. As found by Sordelli and Mayer, agar adsorbed on bacteria produces agar-reacting antibodies in animals injected with these organisms. 2. False cross-agglutination and precipitin reactions can be produced in sera containing agar-reacting antibodies by organisms grown on agar. Zozaya's publication in this field (3) requires partial revision on this account. 3. There is suggestive immunological evidence of chemical similarity between the specifically reactive groups of agar-agar, and the C substance of the pneumococcus.
The role of CD91 and heat shock proteins in psoriasis
Authors: J. Stebbing, B. Gazzard, M. Bower
Journal: British Journal of Dermatology (2005)

Journal Article The role of CD91 and heat shock proteins in psoriasis Get access British Journal of Dermatology, Volume 152, Issue 6, 1 June 2005, Pages 1095–1097, https://doi.org/10.1111/j.1365-2133.2005.06700.x Published: 01 June 2005
Familial Pyrimidinemia and Pyrimidinuria Associated with Severe Fluorouracil Toxicity
Authors: Mendel Tuchman, Joel S. Stoeckeler, David T. Kiang, Robert F. O'Dea, Margaret L. Ramnaraine, Bernard L. Mirkin
Journal: New England Journal of Medicine (1985)

RAPIDLY growing tumor cells depend on a high rate of pyrimidine synthesis for the generation of RNA and DNA. Fluorouracil is a pyrimidine-base analogue that acts as an antimetabolite to block the synthesis of deoxythymidylic acid and to disrupt normal RNA function.1 , 2 This compound is frequently employed in combination with other chemotherapeutic drugs for the therapy of certain solid tumors, such as cancers of the breast, ovary, and gastrointestinal tract.3 4 5 The toxicity of fluorouracil can be severe and includes bone marrow suppression, mucosal ulceration, diarrhea, and less frequently, somnolence, upper motor-neuron signs, reversible cerebellar ataxia, and reversible symptoms like those . . .
POSTURAL DRAINAGE OF THE LUNGS
Authors: H. P. Nelson
Journal: BMJ (1934)

The growth of CDS indices should allow creative investors to pit one market against the other, but only to the extent that those indices remain liquid. While there is a large and growing number of CDS indices, and more in the pipeline, the products most tied to CDO collateral are the North American and European corporate indices along with the ABX.HE index on sub-prime home equity loans and the CMBX.NA index on CMBS. The investment-grade indices, CDX.NA.IG and its European cousin, the iTraxx-IG series, are the most liquid and offer the most dynamic hedging, speculating, and investment opportunities. The CDX.NA.HY high-yield index offers a good example of an index that has fizzled. That index began as a fairly liquid index, offering dealers a means of hedging their pipelines, but many traders abandoned it when they discovered it often trades independently of the cash and single-name CDS markets, proving the point that customer flow is essential to the long-term success of a young index <b>TOPICS:</b>CLOs, CDOs, and other structured credit, mutual fund performance, international
Advances in Gastroenterology, Hepatology and Clinical Nutrition
Authors: Gregory Schnell
Journal: JAMA (1997)

<i>Advances in Gastroenterology, Hepatology and Clinical Nutrition</i>serves as a useful and enjoyable journal for the practicing gastroenterologist. This new journal condenses significant contributions from other journals and publishes them with commentaries from experts from a variety of fields not restricted to gastroenterology. The condensations are prepared by the publisher; the commentators have published extensively in the specific fields in which they comment. Each issue includes at least one in-depth original review article. All articles pertain to topics that clinical gastroenterologists deal with frequently. In addition to the review articles and commentaries, each issue has a section entitled "News in Brief," which offers short reviews of current articles from major journals. These add to the completeness of the journal and allow the physician a broader view of articles published in the field.