tbuckley/cabot-search huggingface dataset:
Revealing the Incidentalome When Targeting the Tumor Genome
Authors: Yvonne Bombard, Mark Robson, Kenneth Offit
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On Traumatic Cataract: With Results of Sixty Operations
Authors: J. R. Wolfe
Journal: BMJ (1872)

performed quite recently for the removal of a recurrent colloid tumour from the inner side of the thigh.A large tract of skin was taken away, and the internal saphenous system of veins was destroyed.The very large wound which resulted was dressed in the manner I have described, and subsequently water-dressing, and occasionally poultices, were had recourse to.The process of repair was hindered in this case by the cedema which resulted from the hurt to the venous system; and it was some weeks before the external saphenous and the deep veins com- pensated for the loss of the internal saphenous vessels.
Abstract 5440: Activity of mesothelin-targeted immunotoxin RG7787 against triple-negative breast cancer
Authors: Christine Alewine, Emily Maon-Osann, Ira Pastan
Journal: Cancer Research (2014)

Abstract Mesothelin (MSLN) is a cell surface glycoprotein normally expressed by mesothelial cells of the pleura, pericardium and peritoneum, but also highly expressed in mesothelioma, pancreatic and ovarian cancers. It was recently reported that many triple negative breast cancers (TNBCs) also express MSLN. RG7787 is a next generation, deimmunized recombinant immunotoxin (RIT) consisting of a high-affinity anti-MSLN Fab fragment for targeting, fused to a 24 kD fragment of Pseudomonas exotoxin A for cell killing. Here, we demonstrate using flow cytometry that the TNBC cell lines HCC70 and SUM149 express significant MSLN on the cell surface. HCC70 and SUM149 are sensitive to RG7787 and related RITs with IC50 values in the subnanomolar range. RG7787 has less off-target toxicity in mice than earlier mesothelin-targeted immunotoxins and could be safely administered to mice at six-fold higher doses. RG7787 shrinks HCC70 tumor xenografts grown in athymic nude mice by &amp;gt;40% and produces a 10 day delay in tumor progression compared to vehicle (p &amp;lt; 0.02). Tumor volume decreased by &amp;gt;85% when RG7787 was given following paclitaxel, a statistically significant improvement over paclitaxel alone. Together these data demonstrate that RG7787 has significant activity against TNBC and warrants further study as a treatment for this malignancy. Citation Format: Christine Alewine, Emily Maon-Osann, Ira Pastan. Activity of mesothelin-targeted immunotoxin RG7787 against triple-negative breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5440. doi:10.1158/1538-7445.AM2014-5440
Combining specialist and primary health care teams for HIV positive patients: retrospective and prospective studies
Authors: S. Smith, J. Robinson, J. Hollyer, R. Bhatt, S. Ash, S. Shaunak
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To develop and evaluate a model of health care for HIV positive patients involving specialist, hospital based teams and primary health care teams. <b>Design</b>: One year retrospective and 2 1/2 year prospective study. <b>Setting</b>: Two hospitals in west London and 88 general practitioners in 72 general practices. <b>Subjects</b>: 209 adults with HIV infection. <b>Intervention</b>: General practitioners enrolled in the project were faxed structured outpatient clinic summaries. When hospital inpatients were discharged, a brief discharge summary was faxed. General practitioners had access to consultant physicians skilled in HIV medicine through a 24 hour mobile telephone service. An HIV/AIDS management and treatment guide containing relevant local information was produced. Quarterly discussion forums for general practitioners were held, and a regular newsletter was produced. <b>Main outcome measures</b>: Hospital attendance and general practitioner consultations; perceived benefits and problems of patients and general practitioners. <b>Results</b>: The average length of a hospital inpatient stay was halved for those patients who had participated in the project for two years, and the average number of visits to the outpatient clinic per month fell for patients with AIDS. There was a substantial increase in the number of visits to general practitioners by patients with AIDS and symptomatic HIV infection. Patients and general practitioners both felt that the standard of health care provided had improved. <b>Conclusions</b>: This model of health care efficiently and effectively utilised existing teams of hospital and primary health care professionals to provide care for HIV positive patients. Simple, prompt, and regular communication systems which provided information relevant to the needs of general practitioners were central to its success.
Lead in Bone: Sampling and Quantitation Using K X-Rays Excited by 109 Cd
Authors: D. R. Chettle, M. C. Scott, L. J. Somervaille
Journal: Environmental Health Perspectives (1991)

Lead in bone can be measured in vivo using gamma-rays from a 109Cd source to excite lead K X-rays. Normalization of lead X-ray amplitudes to that of the elastically backscattered 88 keV gamma-rays produces a determination of the concentration of lead in bone mineral that is accurate and insensitive to variations in measurement or bone geometry. For in vivo tibia measurements, a typical precision (1 SD) of +/- 5 micrograms lead (g bone mineral)-1 is achieved for an effective dose equivalent of 2.1 microSv. Measurement can be made of any superficial bone site, but precision will vary approximately as the inverse of the square root of the mass of bone mineral sampled. The apparatus required for this technique is readily transportable, and mobile laboratory facilities are easily established.
Modulated release of IdUrd from poly (d,l-lactide-co-glycolide) microspheres by addition of poly (d,l-lactide) oligomers
Authors: Annabelle Géze, Marie-Claire Venier-Julienne, Patrick Saulnier, Pascale Varlet, Catherine Daumas-Duport, Patrick Devauchelle, Jean-Pierre Benoit
Journal: Journal of Controlled Release (1999)
Extracorporeal life support for treatment of children with enterovirus 71 infection-related cardiopulmonary failure
Authors: Sheng-Ling Jan, Shing-Jong Lin, Yun-Ching Fu, Ching-Shiang Chi, Chung-Chi Wang, Hao-Ji Wei, Yen Chang, Betau Hwang, Po-Yen Chen, Fang-Liang Huang, Ming-Chih Lin
Journal: Intensive Care Medicine (2009)
Carcinogenicity Testing of Drugs
Authors: John C. Ballin
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The National Cancer Institute (NCI) has begun a long-term project of testing commonly used drugs for their possible carcinogenic effect in animals. In conducting these tests, the NCI uses a standard protocol that involves giving drugs for long periods (generally lifetime feeding) in large doses to mice, rats, and other experimental animals. The doses employed often exceed the usual human dose (on a body-weight basis) by factors of 50-, 100-, or 1,000-fold. Results of such tests have recently been released for reserpine, a common antihypertensive drug, and methapyralene, an antihistamine. Under the conditions of the NCI protocol, it has been suggested that these drugs have carcinogenic potential in animals. Even if there may be no reason to question the validity of these tests, it should be pointed out that the conditions of use in such tests bear little relation to the conditions of use in human patients.
Cocaine and Rhabdomyolysis
Authors: Randy L. Howard
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 January 1989Cocaine and RhabdomyolysisRandy L. Howard, MD, William D. Kaehny, MDRandy L. Howard, MD, William D. Kaehny, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-1-90 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Herzlich and colleagues reported three cases of rhabdomyolysis related to cocaine use (1). We would like to comment on two aspects of their report. The evidence supporting "the ability of cocaine to produce rhabdomyolysis" is insufficient. Also, the statement that myoglobinuria is characterized by heme-positive urine with either no erythrocytes or a minimal number of erythrocytes may be misleading.The list of reported causes for rhabdomyolysis is long, but includes compression, ethanol ingestion, and seizures as the commonest causes (2). To show a direct relation between cocaine use and rhabdomyolysis, at least these causes must be excluded....References1. HerzlichArsuraPagalaGrob BEMD. Rhabdomyolysis related to cocaine abuse. Ann Intern Med. 1988;109:335-6. LinkGoogle Scholar2. GabowKaehnyKelleher PWS. The spectrum of rhabdomyolysis. Medicine (Baltimore). 1982;61:141-52. CrossrefMedlineGoogle Scholar3. MerigianRoberts KJ. Cocaine intoxication: hyperpyrexia, rhabdomyolysis and acute renal failure. Clin Tox. 1987;25:135-48. Google Scholar4. SchwartzMcAfee JR. Cocaine and rhabdomyolysis. J Fam Pract. 1987;24:209. MedlineGoogle Scholar5. LombardWongYoung JBJ. Acute renal failure due to rhabdomyolysis associated with cocaine toxicity. West J Med. 1988;148:466-8. MedlineGoogle Scholar1. HerzlichArsuraPagalaGrob BEMD. Rhabdomyolysis related to cocaine abuse. Ann Intern Med. 1988;109:335-6. LinkGoogle Scholar2. Zamora-QuezadaDinermanStadeckerKelly JHMJ. Muscle and skin infarction after free-basing cocaine (crack). Ann Intern Med. 1988;108:564-5. LinkGoogle Scholar3. RothAlarconFernandezPrestonBourgoignie DFJRJ. Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med. 1988;319:673-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver Veterans Administration Medical Center University of Colorado Health Sciences Center Denver, CO 80220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Nordic model: 25 years of drawing the line between earned and capital income in FinlandCocaïneCocaine 1 January 1989Volume 110, Issue 1Page: 90-91KeywordsCocaineEpileptic seizuresEthanolIngestionRhabdomyolysisUrine Issue Published: 1 January 1989 PDF DownloadLoading ...
A Case of Epileptiform Neuralgia Treated by Stretching the Infra-Orbital Nerve: with Remarks
Authors: W. J. Walsham
Journal: BMJ (1880)

THE BRITISH MEDICAL YOURNAL.-1 9 not repeat themn here.Dr. Buchner, as well as Dr. Greenfield, failed to cultivate Bacillus anthracis in hay infusion, as did the latter also in gelatine-water and several other fluids.So far, then, Dr. Greenfield thinks he has succeeded in demonstrating that the virus of splenic fever (the Pacil/is anthracis) is capable of CASE VI.Right Contgenital ngziinalHernia.-W.B., aged 3, was admitted, under the care of MIr.Folker, on April Ist, I879.The internal ring easily admitted the index finger.The left ringwas closed, and both testes had descended.Operation, having been delayed, in order to improve the child's general health, was performed on May ioth, under chloroform.The next day, the little fellow wanted to get * For the notes of this and the follttwing cases I am indebted to our house-surgeon, A-r.
Long-Term Cardiac Outcomes of Treating Chronic Chagas Disease with Benznidazole versus No Treatment
Authors: Rodolfo Viotti, Carlos Vigliano, Bruno Lococo, Graciela Bertocchi, Marcos Petti, María Gabriela Alvarez, Miriam Postan, Alejandro Armenti
Journal: Annals of Internal Medicine (2006)

Background: Benznidazole is effective for treating acute-stage Chagas disease, but its effectiveness for treating indeterminate and chronic stages remains uncertain. Objective: To compare long-term outcomes of patients with nonacute Chagas disease treated with benznidazole versus outcomes of those who did not receive treatment. Design: Clinical trial with unblinded, nonrandom assignment of patients to intervention or control groups. Setting: Chagas disease center in Buenos Aires, Argentina. Patients: 566 patients 30 to 50 years of age with 3 positive results on serologic tests and without heart failure. Measurements: The primary outcome was disease progression, defined as a change to a more advanced Kuschnir group or death. Secondary outcomes included new abnormalities on electrocardiography and serologic reactivity. Intervention: Oral benznidazole, 5 mg/kg of body weight per day for 30 days (283 patients), or no treatment (283 patients). Results: Fewer treated patients had progression of disease (12 of 283 [4%] vs. 40 of 283 [14%]; adjusted hazard ratio, 0.24 [95% CI, 0.10 to 0.59]; P = 0.002) or developed abnormalities on electrocardiography (15 of 283 [5%] vs. 45 of 283 [16%]; adjusted hazard ratio, 0.27 [CI, 0.13 to 0.57]; P = 0.001) compared with untreated patients. Left ventricular ejection fraction (hazard ratio, 0.97 [CI, 0.94 to 0.99]; P < 0.002) and left ventricular diastolic diameter (hazard ratio, 2.45 [CI, 1.53 to 3.95]; P < 0.001) were also associated with disease progression. Conversion to negative results on serologic testing was more frequent in treated patients than in untreated patients (32 of 218 [15%] vs. 12 of 212 [6%]; adjusted hazard ratio, 2.1 [CI, 1.06 to 4.06]; P = 0.034). Limitations: Nonrandom, unblinded treatment assignment was used, and follow-up data were missing for 20% of patients. Loss to follow-up was more common among patients who were less sick. Two uncontrolled interim analyses were conducted. Conclusions: Compared with no treatment, benznidazole treatment was associated with reduced progression of Chagas disease and increased negative seroconversion for patients presenting with nonacute disease and no heart failure. These observations indicate that a randomized, controlled trial should now be conducted.
Fungal Whip Beats the Heart
Authors: Antonio Rivero Román, Isabel Rodriguez-Bailón, Juan José Gómez-Doblas
Journal: Circulation (1999)

A 24-year-old man was admitted to the hospital because of fever, cough, and dyspnea of 4 weeks' duration.The patient gave a history of parenteral drug abuse since he was 17 years old and had been diagnosed with HIV infection 4 years before admission.A chest radiograph showed multiple alveolar infiltrates.Four blood cultures were positive for Candida albicans.Different echocardiographic views of the right heart cavities are shown in the Figure .A long, highly mobile, and whiplike structure can be seen attached to the nonseptal leaflet of the tricuspid valve, traveling from the right atrium (RA) to the right ventricle (RV) with each cardiac cycle.It represents a bizarre form of fungal vegetation that hits the patient's heart with each cardiac beat.
More To Learn from Mary's Story
Authors: Claus A. Pierach
Journal: Annals of Internal Medicine (1993)

Letters1 September 1993More To Learn from Mary's StoryClaus A. Pierach, MDClaus A. Pierach, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with empathy and anger about the Jobean ordeal Southwick [1], his wife, and their family had to endure at a prestigious academic medical center. No final diagnosis was given, and, I wonder, if a cardinal sin committed by Southwick may not have been the initiating event (and if he has not to take at least as much blame as he freely gives to the residents): He prescribed penicillin V potassium for his wife five days before the onset of her symptoms. We are not told how much and for how long the patient took the ...REFERENCE1. Southwick F. Who was caring for Mary? Ann Intern Med. 1993; 118: 146-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Claus A. Pierach, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1993Volume 119, Issue 5Page: 441-442KeywordsPatientsPenicillinPotassiumVasculitis ePublished: 15 August 2000 Issue Published: 1 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 3664: Breast cancer companion diagnostic platform based on objectively defined tumor co-expression patterns stratifies multiple clinical and therapeutic endpoints comparison to existing molecular subtyping definitions
Authors: Daniel R. Rhodes, Scott Tomlins, Dafydd G. Thomas, Paul Williams, Peter Wyngaard, Seth Sadis, Kahuku Oades, Lien Vo, Sukla Chattopadhyay, Yipeng Wang, Byung-In Lee, Joseph Monforte
Journal: Cancer Research (2012)

Abstract Gene expression profiles of human breast tumors have greatly expanded our understanding of the genes and pathways that underlie breast cancer. Profiling studies have also supported a molecular classification of breast cancer. The resulting molecular subtypes Luminal, Basal-like, ERBB2+, and Normal-like were shown to have different prognostic and predictive characteristics. Related studies have led to a proliferation of multigene prognostic and predictive diagnostic tests. Two independent multigene tests, OncoType Dx and MammaPrint, have been shown to be helpful in predicting the risk of recurrence of patients with early stage breast cancer. Current multigene tests consistently prioritize the proliferation, estrogen receptor (ER), and ERBB2 pathways. An alternative approach to identifying key molecular variables within breast cancer is based on a definition of objectively defined tumor co-expression patterns. To this end, we defined co-expression patterns within 56 independent breast cancer molecular profiling datasets representing &amp;gt;5,000 unique patients. We then performed a meta-analysis across datasets to define the most robust, consistently occurring co-expression patterns. These patterns, termed modules, recapitulate the proliferation, ER, and ERBB2 pathways, but also monitor expression of other important variables including core cancer cell growth pathways, immune signaling and microenvironment, and hallmark genomic aberrations. An important feature of co-expression patterns is that a small number of genes serve as an effective surrogate for each module. Thus, we created a single multigene qPCR test that measures the expression of 18 distinct breast cancer modules and validated the test for use with formalin-fixed paraffin-embedded (FFPE) tumor samples. In retrospective microarray scoring analyses with key clinical datasets, and with analysis of FFPE specimens from breast cancer cohorts, we demonstrate that breast cancer modules can be used to recapitulate the molecular subtypes of breast cancer and to have prognostic and predictive properties similar to the current multigene tests. Because they recapitulate existing molecular tests, while also reading out many additional axes of molecular variability, breast cancer modules provide a universal assay with broad application to companion diagnostics development. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3664. doi:1538-7445.AM2012-3664
DOES CANCER ARISE IN CHRONIC GASTRIC ULCER?
Authors: WILLIAM CARPENTER MacCARTY
Journal: JAMA (1922)

There are two questions which have been almost constantly asked by members of the medical profession: Does cancer arise in chronic gastric ulcer? and What percentage of chronic gastric ulcers become malignant? These are unquestionably interesting and important inquiries, but their practical clinical significance has been greatly overestimated; the rather vicious discussion which has taken place in medical societies and in the literature has probably done some harm. Many physicians do not differentiate the things which are of purely scientific interest from those which are of practical importance. From a purely scientific standpoint, neither one of the questions as stated can be correctly answered. No one should state positively that cancer arises in chronic gastric ulcer until one experimentally produces chronic gastric ulcer and produces cancer in the ulcer, and then shows that all of the conditions of the experiments are comparable to the conditions which arise in human beings.
Location of Coronary Arterial Occlusions and Their Relation to the Arterial Pattern
Authors: BERTRAM PITT, PAUL M. ZOLL, HERRMAN L. BLUMGART, DAVID G. FREIMAN
Journal: Circulation (1963)

The present study shows that the coronary artery pattern is not related to the prognosis after infarction nor can it be correlated with the incidence of occlusion or with the severity of atherosclerosis. This analysis re-emphasizes the severity of the occlusive process in patients with angina pectoris and, conversely, the relatively large percentage of patients having coronary occlusion who had either congestive heart failure or who were asymptomatic. The proper selection of patients for coronary artery surgery requires accurate angiography. The occurrence of multiple occlusions in a large number of cases points to certain difficulties in the interpretation of the coronary angiogram and also indicates the extremely limited role endarterectomy may be expected to play in the therapy of angina pectoris. Until such a time as the operative mortality and secondary failure rate, due to restenosis, can be reduced through new surgical technics, coronary endarterectomy should be considered an experimental procedure to be investigated vigorously in the laboratory but not to be applied for therapeutic purposes in man.
Medically unexplained symptoms: (Letter 2 of 5)
Authors: P. J Goadsby
Journal: Journal of the Royal Society of Medicine (2003)

The admirers of Thomas Willis are indebted to Dr O'Connor (March 2003 JRSM 1 ) for adding further evidence that Cerebri Anatome (1664) reflects the religious and political practices of mid-17th-century England.Keele previously noted that the dedication of this famous book can leave no reasonable doubt that Willis