tbuckley/cabot-search huggingface dataset:
Why Has 'Historic' Public Disclosure of Hospital Performance Data Attracted So Little Attention?
Authors: Rebecca Voelker
Journal: JAMA (1995)

CONSUMERS, COMPETITORS, and payers aren't exactly rushing to snap up the first national reports on hospital performance. "After a huge amount of hullabaloo nationally, this has become a great nonevent," says Dennis S. O'Leary, MD, president of the Joint Commission on Accreditation of Healthcare Organizations. Two years ago, when the Joint Commission announced plans to permit public access to some of the information it compiles during the accreditation process, the move was called historic. But during the first 6 weeks that the reports became available, 97 callers placed orders for 167 of the performance profiles. "This is bearing out my expectations," O'Leary adds. <h3>Measuring Hospital Performance</h3> The Joint Commission accredits more than 5200 hospitals and 6000 other health care organizations nationwide. Performance reports currently are available for only about 850 hospitals because they're produced according to the Commission's 3-year accreditation cycle. Reports for all Joint Commission—accredited facilities will be completed
The Medical Device Excise Tax — Over before It Begins?
Authors: Daniel B. Kramer, Aaron S. Kesselheim
Journal: New England Journal of Medicine (2013)

The Affordable Care Act includes a 2.3% tax on domestic sales of medical devices, paid by the manufacturer, which went into effect in January. But after intense industry lobbying, the Senate has voted overwhelmingly, in a nonbinding resolution, to repeal the tax.
NORMAL CARDIAC ANATOMY OF T l - 2 0 1 THREE-DIMENSIONAL IMAGES WITH CORRELATION TO A CLAY HEART MODEL AND CADAVERIC SPECIMENS
Authors: S A Cook, R T Go, W J MacIntyre, C Napoli, D Underwood, D Moodie, I Franco
Journal: Clinical Nuclear Medicine (1981)

Cook, S A; Go, R T; MacIntyre, W J; Napoli, C; Underwood, D; Moodie, D; Franco, I Author Information
Scintiphotographic Evaluation of Patients with Suspected Left Ventricular Aneurysm
Authors: PIERRE RIGO, MALCOLM MURRAY, H. WILLIAM STRAUSS, BERTRAM PITT
Journal: Circulation (1974)

Twenty-two patients with a history of myocardial infarction and suspected of having a left ventricular aneurysm were evaluated by routine clinical studies, gated cardiac blood pool scanning, and contrast left ventriculography. Thirteen patients were found to have a localized left ventricular aneurysm and nine demonstrated diffuse left ventricular hypokinesis on contrast angiography. The patients with localized left ventricular aneurysms could not be separated from those with diffuse left ventricular hypokinesis on the basis of the routine clinical evaluation including the chest roentgenogram or the finding of ST-segment elevation in the electrocardiogram. Scintiphotographic studies identified the nine with diffuse hypokinesis and twelve of the thirteen with a localized left ventricular aneurysm. In one patient with a calcified left ventricular aneurysm filled with clot, the cardiac blood pool scan showed an area of akinesis which corresponded to that seen on contrast angiography, but the aneurysm could not be detected. In nineteen of the patients in whom adequate measurements were obtained, left ventricular end-diastolic volume and ejection fraction by both contrast angiography and gated cardiac blood pool scintiphotography demonstrated a good correlation, r = 0.92 and 0.87, respectively. There was also a good correlation between the extent of left ventricular akinesis seen on contrast angiography and gated scintiphotography, r = 0.97. This study demonstrates that biplane gated cardiac blood pool scans are useful in differentiating patients with localized left ventricular aneurysms from those with diffuse left ventricular hypokinesis.
Polyclonal Long-Term MFGS-gp91phox Marking in Rhesus Macaques after Nonmyeloablative Transplantation with Transduced Autologous Peripheral Blood Progenitor Cells
Authors: Sebastian Brenner, Martin F. Ryser, Uimook Choi, Narda Whiting-Theobald, Eberhard Kuhlisch, Gilda Linton, Elizabeth Kang, Romy Lehmann, Angela Rosen-Wolff, Andrew G. Rudikoff, Ann M. Farese, Thomas J. MacVittie, Joachim Roesler, Mitchell E. Horwitz, Harry L. Malech
Journal: Molecular Therapy (2006)

We have recently reported that the RD114-pseudotyped MFGS-gp91phox vector achieves unprecedented levels of correction of the NADPH-oxidase gp91phox (approved gene symbol CYBB) defect in CD34(+) cells from patients with X-linked chronic granulomatous disease in the NOD/SCID mouse model. Considering clinical use of this vector, we transplanted autologous mobilized peripheral blood CD34(+) progenitor cells, transduced with the RD114-MFGS-gp91phox vector, into two healthy rhesus macaques following nonmyeloablative conditioning. The moderately high levels of in vivo marking seen in the first months following transduction decreased and stabilized at about 8 months posttransplant. Marking for both healthy animals after 15 months was 0.3 to 1.3 vector copies per 100 cells in lymphocytes, neutrophils, and monocytes. Vector insertion analyses performed by linear amplification-mediated PCR and sequencing identified 32 and 45 separate insertion sites in the animals. Identical insertion sites were found in myeloid cells and lymphocytes, demonstrating the successful transduction of lymphomyeloid progenitors. Some inserts landed in the vicinity of genes controlling cell cycle and proliferation. Statistical analyses of insertion sites 1 year posttransplant suggest a high diversity of insertion sites despite low marking.
Codevelopment of Genome-Based Therapeutics and Companion Diagnostics
Authors: Robert T. McCormack, Joanne Armstrong, Debra Leonard
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exorcizing the Spooks
Authors: Lois DeBakey
Journal: JAMA (1974)

<h3>To the Editor.—</h3> I am not sure what the editor means by "harshly accented pretenders to the language" (227:440, 1974). If he means foreigners with heavy accents, I would prefer hearing a Szent-Györgyi or an Albert Einstein in the flesh—harsh accent and all—than slick elocutionists who "understood not a word of what they spoke." The very presence of a man of great ideas infuses an audience with excitement and inspiration, and, generally, his presentation is highly thought-provoking. Listening to a facile version of that man's great ideas delivered by the glib tongue of a professional speechmaker is, by comparison, a banal experience. Anyone, however, with an incomprehensible accent or other speech problem, whether he be genius or less, owes it to his audience to take elocution lessons to correct the defect. Otherwise, his efforts at public speaking are completely self-defeating. If the editor means by "pretenders to the language" those
Health secretary hits back at charges of bias
Authors: J. Warden
Journal: BMJ (1998)

After allegations of bias, the government's appointment procedures to NHS trust boards in England have been largely endorsed by the Commissioner for Public Appointments, Sir Leonard Peach.

The Conservative shadow health secretary, John Maples had complained that a disproportionate number of Labour councillors had been nominated on to boards. In response, the health secretary, Frank Dobson released …
Enhanced release of mitochondrial aspartate aminotransferase (mAST) from anoxic rat heart cell cultures during reoxygenation. Comparison to plasma mAST levels in patients after acute myocardial infarction and after cardiac surgery
Authors: A V. D. LAARSE, H A DAVIDS, L HOLLAAR, W T. HERMENS
Journal: Cardiovascular Research (1981)

Release of enzymes from cytoplasmic and mitochondrial compartments was studied in rat heart cell cultures during and after 1 to 13 h of anoxia. From the cytoplasm, both α-hydroxy-butyrate dehydrogenase (HBDH) and cAST (the cytoplasmic isoenzyme of aspartate aminotransferase (AST)) are released in about equal proportions, reaching levels of about 80% of the original intracellular HBDH and cAST activities after 13 h of anoxia. From the mitochondria, mAST (the mitochondrial isoenzyme of AST) is released with some retardation compared with cAST, reaching levels of 34% of the original intracellular mAST activity after 13 h of anoxia. In contrast to anoxia, reoxygenation induces a rapid release of both mAST and cAST. The activity ratio mAST /total AST in the extracellular fluid varied from 0.06 ± 0.05 (mean ± SEM; n = 4) after 2 h of anoxia to 0.59 ± 0.02 (n = 4) after 10 h of anoxia. This ratio was 0.44 ± 0.07 (n = 4) after 2 h anoxia + 2 h reoxygenation, and 0.59 ± 0.02 (n = 4) after 10 h anoxia + 2 h reoxygenation, and this implies that, after reoxygenation, mAST/total AST is more or less independent of the duration of anoxia. In plasma of patients with acute myocardial infarction, obtained 24 h after onset of infarction, mAST/total AST ratio is low (0.13 ± 0.02, n = 12) at low total AST activities (≤ 80 U litre−1) and significantly (P < 0.01) higher (0.27 ± 0.05, n = 7) at AST activities exceeding 80 U litre−1. In contrast, mAST/total AST ratio in plasma of patients who underwent cardiac surgery, obtained 24 h after onset of cardiac surgery, is high (0.23 ± 0.02, n = 31) at low total AST activities (≤ 80 U litre−1). After comparison of the results obtained with heart cell cultures with those obtained in plasma of patients, this study gives evidence to the hypothesis that reoxygenation or reperfusion leads to oxygen-induced mitochondrial damage (oxygen-paradox) as reflected by a rapid release of considerable amounts of mAST.
Tumor Antigens in Malignant Melanoma.
Authors: Larry Nathanson
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Tumor Antigens in Malignant Melanoma.Larry Nathanson, M.D., (Member), Robert S. Schwartz, M.D.Larry Nathanson, M.D., (Member)Search for more papers by this author, Robert S. Schwartz, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-837_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical observation of spontaneous regression has suggested the possibility of immunologic host defenses in malignant melanoma and prompted our study of tumor antigens in this disease. Seven melanoma patients have been shown to possess an immunoelectrophoretically homogeneous beta globulin that markedly stimulates DNA synthesis by autologous lymphocytes in culture. Cross-reactivity between lymphocytes from these patients and tumor fluids extracted from a single patient with a cystic melanoma has also been found. Appropriate controls fail to show similar effects. Phytohemagglutinin-M stimulated lymphocytes to a lesser degree than did the tumor extracts. A substance immunochemically identical to that found in tumor tissue... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIdentification of an antigen associated with malignant melanoma 1 May 1971Volume 74, Issue 5Page: 837-837KeywordsAntigensDNA synthesisGlobulinsLymphocytesMelanoma Issue Published: 1 May 1971 PDF DownloadLoading ...
Pyronaridine–Artesunate versus Mefloquine plus Artesunate for Malaria
Authors: Ronnatrai Rueangweerayut, Aung Pyae Phyo, Chirapong Uthaisin, Yi Poravuth, Tran Quang Binh, Halidou Tinto, Louis K. Pénali, Neena Valecha, Nong Thi Tien, Salim Abdulla, Isabelle Borghini-Fuhrer, Stephan Duparc, Chang-Sik Shin, Lawrence Fleckenstein
Journal: New England Journal of Medicine (2012)

Pyronaridine–artesunate is an artemisinin-based combination therapy under evaluation for the treatment of Plasmodium falciparum and P. vivax malaria.
Letter: Autoimmune reactions in chronic liver disease.
Authors: M Torruella, C Martin, J Guardia, J M Martinez, R Bacardi, J Tornos
Journal: BMJ (1974)

ratio of 0-5:1 and only 6`o promyelocytes.It was considered that the patient was undergoing a spontaneous remission of marrow hypoplasia and that no treatment was necessary.A month later both peripheral blood and marrow were normal.These cases emphasize the importance of differentiating between acure leukazmia and marrow hypoplasia.If there is any doubt, cytotoxic therapy should be delayed.-Weare, etc.,
Insulin resistance and cigarette smoking
Authors: F S Facchini, C B Hollenbeck, J Jeppesen, Y D Chen, G M Reaven
Journal: The Lancet (1992)

<h2>Abstract</h2> Cigarette smoking is associated with increases in plasma triglycerides and decreases in plasma high density-lipoprotein-cholesterol concentration. These changes not only increase risk of coronary heart disease but also are secondary to resistance to insulin-stimulated glucose uptake or hyperinsulinaemia. To see whether there is a relation between cigarette smoking and insulin-mediated glucose uptake we measured plasma lipid and lipoprotein concentrations, plasma glucose and insulin response to an oral glucose challenge, and insulin-mediated glucose uptake in 40 matched healthy volunteers (20 non-smokers, 20 smokers). Smokers had significantly higher mean (SEM) very-low-density-lipoprotein triglycerides (0·66 [0·10] vs 0·39 [0·03] mmol/l, p<0·02) and cholesterol (0·45 [0·06] vs 0·23 [0·04] mmol/l, p<0·005) concentrations and lower high-density-lipoprotein cholesterol concentrations (1·16 [0·05] <i>vs</i> 1·51 [0·08] mmol/l, p<0·001). Although plasma glucose concentrations in response to the oral glucose load were similar in the two groups, plasma insulin response of the smokers was significantly higher (p<0·001). Finally, smokers had higher steady-state plasma glucose concentrations in response to a continuous infusion of glucose, insulin, and somatostatin (8·4 [0·2] vs 5·0 [0·3] mmol/l, p<0·001), despite similar steady-state plasma insulin concentrations. The findings show that chronic cigarette smokers are insulin resistant, hyperinsulinaemic, and dyslipidaemic compared with a matched group of non-smokers, and may help to explain why smoking increases risk of coronary heart disease.
A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Oral Talactoferrin in Combination with Carboplatin and Paclitaxel in Previously Untreated Locally Advanced or Metastatic Non-small Cell Lung Cancer
Authors: Raghunadharao Digumarti, Yenyun Wang, Ganapathi Raman, Dinesh C. Doval, Suresh H. Advani, Pramod K. Julka, Purvish M. Parikh, Shekhar Patil, Shona Nag, Jayaprakash Madhavan, Ajay Bapna, Annantbhushan A. Ranade, Atul Varadhachary, Rajesh Malik
Journal: Journal of Thoracic Oncology (2011)
Mental model theory and pragmatics
Authors: Jean-Baptiste van der Henst
Journal: Behavioral and Brain Sciences (2000)

Johnson-Laird &amp; Byrne (1991; 1993) present a theory of human deductive reasoning based on the notion of mental models. Unfortunately, the theory is incomplete. The present commentary argues that pragmatic considerations, particularly of the type discussed in Sperber and Wilson (1995), can complement the theory.
Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat
Authors: Kazuhiko Matsuo, Yumiko Ishii, Ying-Shu Quan, Fumio Kamiyama, Yohei Mukai, Yasuo Yoshioka, Naoki Okada, Shinsaku Nakagawa
Journal: Journal of Controlled Release (2010)
Cor Triatriatum (Stenosis of the Common Pulmonary Vein)
Authors: J. R. Belcher, W. Somerville
Journal: BMJ (1959)

HYPERCALCAEMIC SARCOIDOSIS slow and imperfect after correction of the hypercalcaemia bX cortisone.The present case report shows that, in spite of established renal calcinosis, marked and rapid improvement in renal function followed the use of cortisone.There was no change in the degree of renal calcinosis as determined by serial renal biopsy after one month of cortisone therapy, although renal function had returned to normal.The mechanism is therefore unlikely to be the removal of precipitated calcium from the kidney, although this may well be the end-result of continued steroid administration.We suggest that cortisone exerts its beneficial effect on the renal failure of hypercalcaemic sarcoidosis principally by correcting the hypercalcaemia itself. SummaryA case is reported of sarcoidosis with hypercalcaemia, nephrocalcinosis, nephrolithiasis, and renal failure.Treatment with cortisone resulted in lowering of the serum calcium level to normal and improvement in renal function within one month, although serial renal biopsies showed no change in the degree of nephro- calcinosis during this time.It is suggested that renal failure in hypercalcaemic sarcoidosis is not necessarily a reflection of irreversible nephron destruction by calcinosis, but that it may result from the high level of circulating calcium itself adversely affecting renal function.Also, the presence of nephrocalcinosis does not necessarily imply that the response to steroid therapy will be unsatisfactory.
Carpal tunnel syndrome. First manifestation of systemic lupus erythematosus
Authors: M. Sidiq
Journal: JAMA (1972)

Carpal tunnel syndrome was the first manifestation of systemic lupus erythematosus (SLE) in two patients and was also present in one patient with a drug-induced lupus syndrome. All patients obtained relief with conventional treatment. The diagnosis of SLE was made because of a high index of suspicion for connective tissue disease in patients with carpal tunnel syndrome. As part of the examination for connective tissue disease, an antinuclear antibody test should be done in all patients with carpal tunnel syndrome of unclear cause.
The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy
Authors: Hai-Lan Piao, Yu Tao, Rui Zhu, Song-Cun Wang, Chuan-Ling Tang, Qiang Fu, Mei-Rong Du, Da-Jin Li
Journal: Cellular and Molecular Immunology (2012)
Arterial chemoembolization before liver transplantation in patients with hepatocellular carcinoma: marked tumor necrosis, but no survival benefit?
Authors: Karl J. Oldhafer, Ajay Chavan, Nils R. Frühauf, Peer Flemming, Hans J. Schlitt, Stefan Kubicka, Björn Nashan, Arved Weimann, Rudolph Raab, Michael P. Manns, Michael Galanski
Journal: Journal of Hepatology (1998)
Design of Phosphorodiamidate Morpholino Oligomers (PMOs) for the Induction of Exon Skipping of the Human DMD Gene
Authors: Linda J Popplewell, Capucine Trollet, George Dickson, Ian R Graham
Journal: Molecular Therapy (2009)

Duchenne muscular dystrophy (DMD) is caused by out-of-frame mutations of the human DMD gene. Antisense oligonucleotides (AOs) have previously been used to skip additional exons that border the deletions such that the reading frame is restored and internally truncated, but functional, dystrophin expressed. We have designed phosphorodiamidate morpholino oligomer (PMO) AOs to various exons of the human dystrophin gene. PMOs were designed to have their target sites overlapping areas of open RNA structure, as defined by hybridization-array analysis, and likely exonic splicing enhancer (ESE)/silencer sites on the target RNA. The ability of each PMO to produce exon skipping was tested in vitro in normal human skeletal muscle cells. Retrospective analysis of design parameters used and PMO variables revealed that active PMOs were longer, bound to their targets more strongly, had their target sites closer to the acceptor splice site of the exon, overlapped areas of open conformation (as defined by the hybridization or the RNA secondary structure prediction software), and could interfere with the binding of certain SR proteins. No other parameter appeared to show significant association to PMO-skipping efficacy. No design tool is strong enough in isolation; however, if used in conjunction with other significant parameters it can aid AO design. Duchenne muscular dystrophy (DMD) is caused by out-of-frame mutations of the human DMD gene. Antisense oligonucleotides (AOs) have previously been used to skip additional exons that border the deletions such that the reading frame is restored and internally truncated, but functional, dystrophin expressed. We have designed phosphorodiamidate morpholino oligomer (PMO) AOs to various exons of the human dystrophin gene. PMOs were designed to have their target sites overlapping areas of open RNA structure, as defined by hybridization-array analysis, and likely exonic splicing enhancer (ESE)/silencer sites on the target RNA. The ability of each PMO to produce exon skipping was tested in vitro in normal human skeletal muscle cells. Retrospective analysis of design parameters used and PMO variables revealed that active PMOs were longer, bound to their targets more strongly, had their target sites closer to the acceptor splice site of the exon, overlapped areas of open conformation (as defined by the hybridization or the RNA secondary structure prediction software), and could interfere with the binding of certain SR proteins. No other parameter appeared to show significant association to PMO-skipping efficacy. No design tool is strong enough in isolation; however, if used in conjunction with other significant parameters it can aid AO design.
Assessment of the Carotid Arteries
Authors: Camilo R. Gomez
Journal: Annals of Internal Medicine (1989)

ExcerptTo the Editor: In response to Feussner and Matchar's discussion and the related ACP position paper concerning the carotid artery (1, 2), we submit that few physicians untrained in evaluating the nervous system are likely to successfully gather clinical data of quality necessary for diagnostic accuracy and appropriate treatment. Crises of cerebral blood flow are commonly viewed simplistically; seemingly few physicians understand their physiologic bases or the contemporary diagnostic strategies which offer hitherto unavailable information safely and inexpensively.The assumption that ischemia in the region of the internal carotid artery is caused solely by atherosclerosis of its cervical portion (which...
Follow-up Care After Hospitalization
Authors: Gordon T. Moore
Journal: JAMA (1972)

A study of hospitalized patients from a community with a neighborhood health center demonstrated that 39% of those who were previously registered received their follow-up care primarily from the health center after discharge from the hospital. The more frequently the health center was used prior to hospitalization, the greater its likelihood of use for follow-up care. Low referral rate to the health center by the hospital physicians probably contributed to the findings observed.