Basal Cell Nevus Syndrome
Authors: NATHANIEL I. BERLIN
Journal: Annals of Internal Medicine (1966)

Clinical Staff Conference1 February 1966Basal Cell Nevus SyndromeCombined Clinical Staff Conference at the National Institutes of HealthNATHANIEL I. BERLIN, M.D., EUGENE J. VAN SCOTT, M.D., WILLIAM E. CLENDENNING, M.D., HOWELL O. ARCHARD, D.D.S., JEROME B. BLOCK, M.D., CARL J. WITKOP, D.D.S., HARLEY A. HAYNES, M.D.NATHANIEL I. BERLIN, M.D., EUGENE J. VAN SCOTT, M.D., WILLIAM E. CLENDENNING, M.D., HOWELL O. ARCHARD, D.D.S., JEROME B. BLOCK, M.D., CARL J. WITKOP, D.D.S., HARLEY A. HAYNES, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-403 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Nathaniel I. Berlin: This discussion of the basal cell nevus syndrome is presented by the National Cancer Institute.This syndrome was first described by Binkley in 1951, and since that time approximately 100 patients have been described. This rare disorder is characterized by multiple basal cell tumors of the skin, cysts of the jaw, abnormalities of the ribs and metacarpal bones, and several endocrine abnormalities. Response to intravenous administration of parathyroid extract is diminished. Considerable evidence indicates that this is a heritable disorder, and that it may be related to other neoplasms. It is a progressive disorder, and the...References1. POTT P: Chirurgical Observations Relative to the Cataract, the Polypus of the Nose, the Cancer of the Scrotum, the Different Kinds of Ruptures and the Mortification of the Toes and Feet. Hawes, Clarke & Collins, London, 1775. Google Scholar2. VAN SCOTT EJ: Definition of epidermal cancer, in The Epidermis, edited by MONTAGNA, W., LOBITZ, W. C., JR. Academic Press, Inc., New York, 1964, p. 573. CrossrefGoogle Scholar3. EPSTEINMAIBACH WLHI: Cell renewal in human epidermis. Arch. Derm. (Chicago) 92: 462, 1965. CrossrefMedlineGoogle Scholar4. 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Department of Health, Education, and Welfare.Requests for reprints should be addressed to Nathaniel I. Berlin, M.D., Clinical Director, National Cancer Institute, Building 10, Room 4-B-17, National Institutes of Health, Bethesda, Md. 20014. 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