tbuckley/cabot-search huggingface dataset:
Plasma Complement Levels Are Associated with Primary Graft Dysfunction and Mortality after Lung Transplantation
Authors: Rupal J. Shah, Amir M. Emtiazjoo, Joshua M. Diamond, Patricia A. Smith, David W. Roe, Keith M. Wille, Jonathan B. Orens, Lorraine B. Ware, Ann Weinacker, Vibha N. Lama, Sangeeta M. Bhorade, Scott M. Palmer, Maria Crespo, David J. Lederer, Edward Cantu, George J. Eckert, Jason D. Christie, David S. Wilkes
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

Definition of abbreviations: HR = hazard ratio; PASP = pulmonary artery systolic pressure at the time of transplantation; PGD = primary graft dysfunction within 72 h; PRBC = packed red blood cell transfusion within 24 h.HRs with 95% confidence intervals are presented per 1-SD change in complement level.
Principles and Practices of Geriatric Medicine
Authors: Owen W. Beard
Journal: JAMA (1986)

As stated in the preface, "The objective of this textbook, written by authors of international repute, is to provide in a single volume a comprehensive reference source for all who are involved in the medicine of old age." The early chapters are excellently written and present a general perspective on old age and the process of aging. Particular attention should be called to the excellent chapter that not only reviews the effect of aging on neuroendocrine regulation but also presents the effect aging has on the laboratory tests used to evaluate endocrine functions. The chapter "Preventive Aspects of Geriatric Aging" is somewhat disappointing in the casual approach to prevention via immunizations, suggesting that the indication for use of influenza vaccine "would be an approaching epidemic" and that "polyvalent pneumococcal vaccines may also be of use in limiting the spread of infection in an institution." Special medical problems of the aged
Humanistic Medicine in a Modern Age
Authors: Seymour M. Glick
Journal: New England Journal of Medicine (1981)

One does not have to be a pessimist or an incurable victim of nostalgia to agree that modern medicine in the Western world is undergoing some form of crisis. One indication of the depth of the crisis is the attention with which thoughtful people are willing to consider seriously almost any criticism of physicians and of the medical establishment — even such absurd critiques as those of Illich,1 who would have us believe that modern medicine is almost the reincarnation of the Devil himself. Similarly, the proliferation of health cults even within educated and otherwise sophisticated circles bears witness to . . .
Pulmonary Disease in the Acquired Immunodeficiency Syndrome
Authors: JEFFREY A. GOLDEN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986Pulmonary Disease in the Acquired Immunodeficiency SyndromeJEFFREY A. GOLDEN, M.D.JEFFREY A. GOLDEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-286_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor; In a letter, Moser and colleagues (1) have presented the case of a specific patient to emphasize the utility of doing both transbronchial biopsy and bronchoalveolar lavage in the diagnosis of pulmonary problems among patients with the acquired immunodeficiency syndrome (AIDS), as we recently reported (2). In our report, bronchoalveolar lavage and transbronchial biopsy had a diagnostic sensitivity for Pneumocystis carinii pneumonia of 89% and 93%, respectively; together, both had 100% yield for this pneumonia.All aspects of opportunistic infections and AIDS are constantly being re-evaluated and revised. Recently, we prospectively performed bronchoalveolar lavage alone in 40...References1. MOSERTENHOLDERRIDENOUR RMR. Oat-cell carcinoma in transfusion-associated acquired immunodeficiency syndrome [Letter]. Ann Intern Med. 1985;103:478. LinkGoogle Scholar2. BROADDUSDAKESTULBARG CMM. Bronchoalveolar lavage and transbronchial biopsy in the diagnosis of pulmonary infections in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;102:747-52. LinkGoogle Scholar3. FULKERSON W. Current concepts in fiberoptic bronchoscopy. N Engl J Med. 1984;311:511-5. CrossrefMedlineGoogle Scholar4. BIGBYMARGOLSKEECURTIS TDJ. The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome [Abstract]. Am Rev Respir Dis. 1985;131(4 pt 2):A222. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosis of lung disease in acquired immune deficiency syndrome: biopsy or cytology and implications for management. 1 February 1986Volume 104, Issue 2Page: 286-286KeywordsAIDSBiopsyBronchoalveolar lavageOpportunistic infectionsPneumocystis carinii pneumoniaPneumoniaPulmonary diseases Issue Published: 1 February 1986 PDF downloadLoading ...
Hormone Receptors and Breast Cancer
Authors: Andrea Manni
Journal: New England Journal of Medicine (1983)

The hormone dependency of human breast cancer has been known since 1896, when Beatson1 reported regression of inoperable primary tumors after ovariectomy in two premenopausal women. It is now well established that approximately one third of human breast carcinomas are responsive to hormones and will regress after a variety of hormonal manipulations. Until recently, there was no biochemical test that could reliably identify women who were harboring endocrine-dependent neoplasms and were thus likely to benefit from hormonal therapy. In 1971 Jensen et al.2 first reported that measurement of estrogen receptors in a tumor-biopsy specimen was useful in predicting the response . . .
The Devil and Dr Barnes
Authors: P. Dormer
Journal: BMJ (1996)

Howard Greenfield Marion Boyars, £12.95, pp 310 ISBN 0 7145 3006 9

Albert Barnes MD was an American monster who collected art on a grand scale and turned famous scholars and young academics into milksops. Barnes became the Richard Nixon of an art world which he terrorised from his infamous Barnes Foundation in Philadelphia.

Barnes (1870-1951) was a doctor who did not practise because it would have taken him too long to make money from the profession. He made his millions quickly from manufacturing Argyrol, a silver compound based antiseptic which he and a German chemist invented. Having made his pile he started buying art. He bought Renoirs by the armful and he was the …
Rubella vaccination during oral contraceptive care.
Authors: A J Rose, K Mole
Journal: BMJ (1977)

The recommendation of the British Department of Health and Social Security (DHSS) is that women regularly receiving family planning advice should be screened serologically and offered rubella vaccination if seronegative. M. Gringas et al. have shown that this practice can be carried out, but ignores the feature of "doctor compliance" in nonresearch facilites where large-scale screenings are not currently possible. Better results can be obtained by "blind" vaccination of all candidates for contraception to be offered at the expieration of a 3-month prescription of the pill. This "blind" vaccination poses the problem of a possible pregnant vaccinee. In this case, distinguishing the maternal rubella-specific IgM (product of recent vaccination) from rubella-specific IgG (from previous rubella infection) could determine the necessity of termination. Furthermore, rubella vaccine, if given to a seropositive woman, has not yet been exonerated from all possible risk. Under the present program, payment for vaccinating male staff working in antenatal clinics is withheld unless proved seronagative. Family planning clinics should have a rubella policy.
Central venous catheter embolism
Authors: D Verel
Journal: BMJ (1978)

given that of five patients with deteriorating renal function, three were on gentamicin alone and two on gentamicin plus a cephalosporin.Of the three on gentamicin alone they say, "All three patients were also suffering from transplant rejection and toxaemia, and interpretation of these results is therefore difficult."Of the two on gentamicin plus a cephalosporin they say, "Although in both cases rejection was occurring, we could not exclude nephrotoxicity."They do not present any evidence to explain why in the one situation they conclude, "attributable nephrotoxicity not observed," while in the other they conclude, "may have produced nephrotoxicity."Furthermore, in view of the accumulating evidence that gentamicin appears to be potentially more nephrotoxic than some other aminoglycosidesl-3 attention might have been drawn to the fact that, whether or not it was attributable, all five patients who showed deteriorating renal function were actually receiving gentamicin and not one of the other aminoglycosides included in the study.
The multiple factors affecting the association between atopic dermatitis and contact sensitization
Authors: J. P. Thyssen, J. P. McFadden, I. Kimber
Journal: Allergy (2013)

Abstract Atopic dermatitis and allergic contact dermatitis are both common skin diseases having an immune pathogenesis. There has been considerable interest about their inter‐relationships with regard to altered susceptibility. Recent investigations have shed new light on this important question, and in this article, we explore whether there is evidence that atopic dermatitis affects the risk of contact sensitization and allergic contact dermatitis. The use of topical products to treat xerotic and inflamed skin in atopic dermatitis often results in a higher prevalence of sensitization to, for example, fragrances and other ingredients in emollients. Moreover, the prevalence of metal allergy seems to be increased, probably due to compromised chelation of the metals in the stratum corneum of patients with atopic dermatitis. However, conversely, the T‐helper cell 2 bias that characterizes immune responses in atopic dermatitis appears to lower the risk of contact sensitization compared to healthy controls. Based on these observations, we conclude that multiple factors affect the association between atopic dermatitis and contact sensitization, and that these need to be appreciated in the clinical management of atopic dermatitis patients.
Incidence of Acute Mountain Sickness at Intermediate Altitudes-Reply
Authors: A. Bruce Montgomery
Journal: JAMA (1989)

In Reply.—  The purpose of the article entitled Incidence of Acute Mountain Sickness at Intermediate Altitude was to alert physicians that this is a real syndrome. Dr Houston clearly concurs. Where we differ is in our definitions of  mountain sickness. Our study 1 included subjects with mild symptomatology, albeit symptoms not from travel or hypochondriasis, as was shown by the paucity of these symptoms in the sea-level control group. If our definition of acute mountain sickness had required disabling symptoms needing medication, the incidence would be 12%, about what Dr Houston predicts. As noted in the article, 2 the even higher incidence in the placebo group of the dexamethasone treatment study is probably a consequence of selection, as subjects with a history of a disease are more likely to enter a drug trial. Perhaps more important than accurate epidemiologic research is a consensus on the nomenclature of the altitude-related
An Unusual Late Complication of Pulmonary Artery Banding
Authors: JAMES R. OSBORN, ROBERT J. HALL, DEAN F. WINN, ROBERT S. CAPPER, HU A. BLAKE
Journal: Circulation (1966)

An unusual case is reported in which severe cyanosis developed many months following banding of the pulmonary artery. The obstruction resulted from a thrombus which originated beneath the band and eventually almost completely occluded the main pulmonary artery. The late onset of severe cyanosis following a banding procedure should suggest this rare complication and prompt definitive hemodynamic and angiographic studies.
Some experiments involving animals require greater scrutiny, say scientists
Authors: M. Limb
Journal: BMJ (2011)

<h3>Objectives</h3> To assess the safety and effectiveness of administering local steroid injections in an operational field hospital environment. <h3>Method</h3> A prospective study of patients presenting to the physiotherapy department at the British Military Hospital (BMH) Shaibah, Iraq was undertaken from July 2006 – September 2006. Patients with a condition amenable to local steroid injection and who had not improved with conservative therapy were considered for the study. They then underwent local injection with steroid and local anaesthetic. <h3>Results</h3> During this period 12 patients were identified that fitted the criteria for local steroid injection. This represented 7% (12/179) of patients who were seen by the physiotherapy department in either an in or out-patient setting. All patients were injected with local anaesthetic and steroid injection with a single dose of intravenous antibiotic as antimicrobial cover. 10/12 (83.3%) were able to return to their unitwithin this theatre of operation. The only complication was one case of post injection flare of pain, which settled after 48 hours. <h3>Conclusion</h3> The use of local steroid injection, as an adjunct to physical therapy, can enable service personnel to remain in the theatre of operations. These patientsmay have otherwise required aero medical evacuation. We consider the use of a local steroid injection to be a safe and effective intervention in certain patients where conservative measures alone do not work. This study highlights the safety of using steroid injections in an operational field hospital setting. Further large scale studies may help corroborate this conclusion.
Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group
Authors: Marta Salido, Cristina Baró, David Oscier, Kostas Stamatopoulos, Judith Dierlamm, Estela Matutes, Alexandra Traverse-Glehen, Francoise Berger, Pascale Felman, Catherine Thieblemont, Stefan Gesk, Anastasia Athanasiadou, Zadie Davis, Anne Gardiner, Fuensanta Milla, Ana Ferrer, Manuela Mollejo, Maria José Calasanz, Lourdes Florensa, Blanca Espinet, Elisa Luño, Iwona Wlodarska, Gregor Verhoef, Marta García-Granero, Antonio Salar, Theodora Papadaki, Sergio Serrano, Miguel A. Piris, Francesc Solé
Journal: Blood (2010)
Skin testing with recombinant allergens rBet v 1 and birch profilin, rBet v 2: Diagnostic value for birch pollen and associated allergies
Authors: Gabrielle Pauli, Jean Philippe Oster, Philippe Deviller, Suzanne Heiss, Jean Claude Bessot, Markus Susani, Fatima Ferreira, Dietrich Kraft, Rudolf Valenta
Journal: Journal of Allergy and Clinical Immunology (1996)
Automated Suprathreshold Static Periumetry Screening for Detecting Neuro-ophthalmologic Disease
Authors: R. Michael Siatkowski, Byron L. Lam, Douglas R. Anderson, William J. Feuer, Amy B. Halikman
Journal: Ophthalmology (1996)

Purpose: To devise and evaluate a rapid, accurate, and cost-effective method of detecting neuro-ophthalmologic visual field defects. Methods: One hundred fifty-nine consecutive patients were evaluated with 76-point, central 30° automated static threshold perimetry on the Humphrey Visual Field Analyzer, as well as by a 76-point, central 30° suprathreshold examination with the central reference levels set at 2 or 4 dB lower than the estimated normal median central reference level adjusted for age. Six masked readers reviewed the fields. Their readings were compared with those of the other observers, as well as with the final diagnoses as determined from all available clinical information. Results: In detecting abnormality, the full-threshold 30° test had a sensitivity (percent of eyes with true field defects identified by the field test) of 93% or 99% (depending on whether borderline results were counted as a positive or negative test) and a specificity (percent of cases without true field defects appropriately identified by the field test) of 71% or 91%. In comparison, the 4-dB offset suprathreshold test had a sensitivity (averaged over all reviewers) of 79% or 87% and a specificity of 81% or 89%, whereas the 2-dB test had a sensitivity of 87% or 94% and a specificity of 73% or 85%. The mean duration of the suprathreshold tests was 3.5 ± 1.0 minute, compared with 14.8 ± 2.8 minutes for the full-threshold technique. Conclusion: The central 30°, 76-point, 2-dB offset suprathreshold automated perimetry is more rapid and nearly as effective as the full-threshold test in detecting visual field abnormalities due to neuro-ophthalmologic disease. More quantitative, full-threshold perimetric strategies should be used in all equivocal cases and to follow progression of established disease.
Education, Entrepreneurs, and Ennui
Authors: Stephen M. Hanson
Journal: JAMA (1968)

<h3>To the Editor:—</h3> It seems to me that the article, "Education, Entrepreneurs, and Ennui" by Dr. William Keith C. Morgan (<b>202</b>, Dec 4, 1967, adv p 234) could be listed as "satire" only by stretching the meaning of this word. It struck me as a cogent, pithy jeremiad on a genuinely deplorable situation.
SHALL WE OPERATE ON DEFORMED SEPTA IN CASES OF ATROPHIC RHINITIS?
Authors: KATE W. BALDWIN
Journal: JAMA (1904)

Much has been written about this very greatly afflicted class of patients, and little has been accomplished. They should receive our best care for their own good and for the relief of the people with whom they come in contact. True, our horizon is the limit of our vision. The atrophic patient does not know the pleasure derived through the sense of smell; at the same time he does not appreciate the disgusting foul smell which makes him an undesirable member of society. The ancient Greeks considered ozena a good and sufficient cause for divorce. It was also considered a bar to the priesthood. Surely we may well advise against transmission to future generations. Where a patient is convinced that he is an offense wherever he goes much has been done to gain the necessary perseverance in treatment. With eternal vigilance on the part of both physician and patient, results
Judaism and Medical Ethics
Authors: FRED ROSNER
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 November 1984Judaism and Medical EthicsFRED ROSNER, M.D.FRED ROSNER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-721_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recently published American College of Physicians Ethics Manual (1) contains the following statement of questionable accuracy: "Much of Jewish medical tradition was based on Mesopotamian precepts, and after the period of servitude in Egypt, these precepts incorporated ideas taken from the Egyptian system."Judaism, the founding monotheistic religion, embodies within its philosophy and legislation a system of ethics—a definition of moral values. Judaism emphatically insists that the norms of ethical conduct may be governed neither by the accepted notions of public opinion nor by the whims of the individual conscience. Moral values are not matters of...Reference1. . American College of Physicians Ethics Manual: Part 1. History of medical ethics, the physician and the patient, the physician's relationship to other physicians, the physician and society. Ann Intern Med. 1984;101:129-37. LinkGoogle Scholar1. . American College of Physicians Ethics Manual: Part 1. History of medical ethics, the physician and the patient, the physician's relationship to other physicians, the physician and society. Ann Intern Med. 1984;101:129-37. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRED ROSNER, M.D.Affiliations: Queens Hospital Center Affiliation of the Long Island Jewish-Hillside Medical Center Jamaica, NY 11432 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1984Volume 101, Issue 5Page: 721-722KeywordsLegislationMedical ethics ePublished: 1 December 2008 Issue Published: 1 November 1984 PDF downloadLoading ...
GRAFTING AND TRAUMATIC DISSEMINATION OF CARCINOMA IN THE COURSE OF OPERATIONS FOR MALIGNANT DISEASE
Authors: WILLIAM J. MAYO
Journal: JAMA (1913)

Ontogenous grafting of carcinoma may occur spontaneously especially at points of contact, as about the labia, vulva, and in the gastro-intestinal tract. In the large intestine, at least, grafting may occur not only at points where the mucosa of the opposite wall of the intestine comes in contact with the carcinoma, but has been known to occur by the process of seeding, in which malignant cells from the tumor have become detached and grafted on the surface of the mucous membrane, sometimes at a considerable distance from and usually below the original growth. The grafting may take place above the growth as well, the cells being carried to proximal points by antiperistalsis.
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
Authors: Renier J. Brentjens, Isabelle Rivière, Jae H. Park, Marco L. Davila, Xiuyan Wang, Jolanta Stefanski, Clare Taylor, Raymond Yeh, Shirley Bartido, Oriana Borquez-Ojeda, Malgorzata Olszewska, Yvette Bernal, Hollie Pegram, Mark Przybylowski, Daniel Hollyman, Yelena Usachenko, Domenick Pirraglia, James Hosey, Elmer Santos, Elizabeth Halton, Peter Maslak, David Scheinberg, Joseph Jurcic, Mark Heaney, Glenn Heller, Mark Frattini, Michel Sadelain
Journal: Blood (2011)
Digoxin for Atrial Fibrillation: A Drug Whose Time Has Gone?
Authors: Rodney H. Falk, Jeffrey I. Leavitt
Journal: Annals of Internal Medicine (1991)

For over 200 years digitalis compounds have been used to treat atrial fibrillation. The rapid ventricular response to atrial fibrillation is frequently treated with digoxin to produce a controlled heart rate. Digoxin has also been proposed as a treatment for terminating recent-onset atrial fibrillation, for maintaining sinus rhythm after an episode of atrial fibrillation, and as prophylactic therapy in patients with paroxysmal atrial fibrillation to prevent excessive tachycardia during a paroxysm. Perhaps because it has been used for so long, few of these indications have been studied scientifically until recently. Studies now suggest that in patients with atrial fibrillation, digoxin is a poor drug for controlling heart rate during exertion, has little or no effect in terminating the arrhythmia, and may occasionally aggravate paroxysmal atrial fibrillation. Despite adequate digitalization, the heart rate at the onset of a paroxysm of fibrillation in patients receiving the drug does not differ from the heart rate in patients not receiving it. This article discusses the current role of digoxin in the management of patients with chronic, recent-onset, or paroxysmal atrial fibrillation.