tbuckley/cabot-search huggingface dataset:
Tropoelastin Incorporation into a Dermal Regeneration Template Promotes Wound Angiogenesis
Authors: Yiwei Wang, Suzanne M. Mithieux, Yvonne Kong, Xue‐Qing Wang, Cassandra Chong, Ali Fathi, Fariba Dehghani, Eleni Panas, John Kemnitzer, Robert Daniels, Roy M. Kimble, Peter K. Maitz, Zhe Li, Anthony S. Weiss
Journal: Advanced Healthcare Materials (2014)

Severe burn injury results in substantial skin loss and cannot be treated by autografts. The Integra Dermal Regeneration Template (IDRT) is the leading synthetic skin substitute because it allows for wound bed regeneration and wound healing. However, all substitutes suffer from slow blood vessel ingrowth and would benefit considerably from enhanced vascularization to nurture tissue repair. It is shown here that by incorporating the human elastic protein tropoelastin into a dermal regeneration template (TDRT) we can promote angiogenesis in wound healing. In small and large animal models comprising mice and pigs, the hybrid TDRT biomaterial and IDRT show similar contraction to autografts and decrease wound contraction compared to open wounds. In mice, TDRT accelerates early stage angiogenesis by 2 weeks, as evidenced by increased angiogenesis fluorescent radiant efficiency in live animal imaging and the expression of endothelial cell adhesion marker CD146. In the pig, a full thickness wound repair model confirms increased numbers of blood vessels in the regenerating areas of the dermis closest to the hypodermis and immediately below the epidermis at 2 weeks post‐surgery. It is concluded that including tropoelastin in a dermal regeneration template has the potential to promote wound repair through enhanced vascularization.
Fracture-dislocation of Ankle in Flying Accidents
Authors: T. James
Journal: BMJ (1944)

A method for ensuring a higih protein nitrogen intake in the treat- ment of coeliac disease and allied conditions by the oral administra- tion of proteolysed beef is described.Details of the method of preparation of the digest, which can be satisfactorily carried out in any well-equipped hospital dispensary, are given.Two cases of coeliac disease treated daily with proteolysed beef for 11 months and 10 months, respectively, are reported.It is hoped that the new method, which is based on the principle of the need for a high protein diet in coeliac disease, will stimulate further clinical trials.We wish to thank Dr. R. Sleigh Johnson, under whose care the patients were admitted to hospital, for permission to publish the case notes, and for his helpful criticism of this paper.
Gastrointestinal bleeding: capsules, balloons, and spirals!
Authors: S. Rana, D. Bhasin
Journal: Endoscopy (2010)

Gastrointestinal bleeding continues to be a challenging emergency for gastroenterologists despite the advances in modern medicine. Treatment of bleeding from gastric varices is a life-threatening emergency, and the lack of an ideal and universally acceptable method for arresting the bleed further complicates the situation. Over the years, small-bowel endoscopy has evolved from push enteroscopy to capsule endoscopy, balloon enteroscopy, and more recently to spiral enteroscopy. In addition, the concept and preliminary results of a therapeutic capsule endoscope are fascinating and it seems to be a technology of the future. Over time, the management of patients with bleeding peptic ulcers has radically changed from the administration of “tonnes” of antacids and emergency surgery to aggressive antisecretory therapy and various endoscopic injection, thermal, and mechanical hemostatic methods that reduce the need for emergency surgery. Now attempts are being made to identify the cost-effective dose of proton pump inhibitors (PPIs) that can be used following endoscopic therapy of bleeding peptic ulcers. Here, we review five studies published during the past year that reflect the state-of-the-art on the topic of gastrointestinal bleeding.
Coagulation-dependent mechanisms and asthma
Authors: Michael A. Matthay, John A. Clements
Journal: Journal of Clinical Investigation (2004)

In several clinical disorders, there are interactions between inflammation-dependent tissue injury and thrombin formation, fibrin deposition, and impaired fibrinolysis. New evidence generated from a mouse model of allergic airway hyperreactivity suggests that disordered coagulation and fibrinolysis may contribute to the pathogenesis of asthma. The inflammatory mechanisms that lead to airway smooth muscle contraction and airway hyperresponsiveness may be associated with accumulation of extravascular fibrin, plasma exudates, and inflammatory cells that can lead to airway closure.
Microvascular vasodilatation in feet of newly diagnosed non-insulin dependent diabetic patients.
Authors: D D Sandeman, C A Pym, E M Green, C Seamark, A C Shore, J E Tooke
Journal: BMJ (1991)

were widely used for mild hypertension in the 1960s and '70s might have done more harm than good,44 and this mistake may be potentially repeated in subjects with hypercholesterolaemia.Doubts are even stronger in women: firstly, the effect of cholesterol lowering remains to be shown and, secondly, the incidence of coronary heart disease is already very low in middle aged women.Further studies of the long term effects of individual intervention on both biological processes and quality of life are needed, especially for women and other low risk groups.In the mean time it is prudent to recall that a high serum cholesterol concentration is caused by unhealthy eating habits.Our analysis above indicates that individual interventions should be implemented with great caution.The widely recommended inter- vention limits' 6 4 should be adjusted to include only a small proportion of the population.To what extent women should be included in such programmes is unclear.The use of drugs should be reserved for subjects with genetic hypercholesterolaemia or those who are otherwise at very high risk of arteriosclerotic disease.We thank Anne Brit Westerheim, Per Maehlumshagen, and Gavin Mooney for their valuable contributions.
Regional Systems of Care to Optimize Timeliness of Reperfusion Therapy for ST-Elevation Myocardial Infarction
Authors: Henry H. Ting, Charanjit S. Rihal, Bernard J. Gersh, Luis H. Haro, Christine M. Bjerke, Ryan J. Lennon, Choon-Chern Lim, John F. Bresnahan, Allan S. Jaffe, David R. Holmes, Malcolm R. Bell
Journal: Circulation (2007)

Quality improvement efforts have focused on strategies to improve the timeliness of reperfusion therapy in ST-elevation myocardial infarction patients who present to hospitals with and without percutaneous coronary intervention (PCI) capability. We implemented and evaluated a protocol to optimize the timeliness of reperfusion therapy and to coordinate systems of care for a PCI center and 28 regional hospitals located up to 150 miles away across 3 states.The present study focused on a prospective, observational cohort of 597 patients who presented with ST-segment elevation and within 12 hours of symptom onset to Saint Marys Hospital and 28 regional hospitals up to 150 miles away between May 2004 and December 2006. The Mayo Clinic ST-elevation myocardial infarction protocol implemented strategies to improve timeliness of reperfusion therapy and to coordinate systems of care for transfer between hospitals. The study sample consisted of 258 patients who presented to Saint Marys Hospital and were treated with primary PCI (group A), 105 patients who presented to a regional hospital with symptom onset >3 hours and then were transferred for primary PCI (group B), and 131 patients who presented to a regional hospital with symptom onset <3 hours and were treated with full-dose fibrinolytic therapy (group C). For groups A and B, median door-to-balloon times were 71 and 116 minutes, respectively. Door-to-balloon time <90 minutes was achieved in 75% of group A and 12% of group B. Median door-to-needle time was 25 minutes for group C, and 70% had door-to-needle time <30 minutes.The Mayo Clinic ST-elevation myocardial infarction protocol demonstrates the feasibility of implementing strategies to optimize the timeliness of reperfusion therapy and the times that can be achieved through coordinated systems of care for ST-elevation myocardial infarction patients presenting to a PCI center (Saint Marys Hospital) and 28 regional hospitals without PCI capability located up to 150 miles away across 3 states.
Emerging Treatment Options for Advanced-Stage Mycosis Fungoides
Authors: Reed E. Drews
Journal: Journal of Clinical Oncology (2012)

A 72-year-old man with a 3-year history of hypersensitivity skin reaction managed with topical steroids and ultraviolet B (UVB) radiation develops skin tumors chiefly involving his face. After a diagnosis of stage IIB mycosis fungoides (MF), he begins oral low-dose weekly methotrexate with partial response lasting 5 months. Subsequently, he receives six cycles of weekly gemcitabine and achieves a partial response with resolution of skin tumors but persistence of scattered patches and plaques ( Fig 1 ). He begins daily bexarotene and interferon alfa (IFN-α) three times per week while continuing topical steroids. When scattered patches and plaques progress 7 months later, UVB radiation is added to his regimen. His disease remains well controlled until 17 months later, when he develops pneumonia complicated by pericarditis, requiring discontinuation of IFN-α. Over the next year, he continues bexarotene maintenance therapy and topical steroids but requires localized radiation therapy to isolated patch and tumor lesions. When patch lesions become more extensive, he receives total-skin electron beam therapy (TSEBT). Nearly 4 years after diagnosis of stage IIB MF and 5 months after completion of TSEBT, two tumor lesions redevelop on his face and scalp. The scalp tumor has overlying epidermal change with ulceration; the face tumor is subdermal with minimal overlying epidermal change and obstructs the right external auditory meatus ( Fig 1 D). You consider management options.
A STUDY OF THE MECHANISM OF RECOVERY FROM LOBAR PNEUMONIA
Authors: Richard H. P. Sia, Oswald H. Robertson, Shutai T. Woo
Journal: The Journal of Experimental Medicine (1928)

Employing a method devised for the investigation of natural immunity and experimental pneumococcus infection, a study has been made of the serum immune changes occurring during the course of lobar pneumonia due to Pneumococcus Types I and II and Group IV, in man. It was found that at the time of crisis or lysis the blood serum acquired constantly the property of promoting pneumococcus killing to a relatively marked degree. Other evidences of antipneumococcus reaction—mouse protection, opsonins, and agglutinins—were also demonstrable in the blood at this time. These immune changes appeared in the majority of cases at the beginning of recovery and failed to occur when the disease terminated fatally. The fact that these observations in human cases are practically identical with previous findings in the experimental disease in cats, enhances considerably the significance of the development of serum immune bodies at the time of crisis since in the experimental animal it was possible to show that the acquisition of passive immunity was associated with greatly increased antipneumococcus resistance.
Altered bile in diabetic diarrhoea.
Authors: A Molloy, G Tomkin
Journal: BMJ (1979)

The size and composition of the bile-salt pools in a group of diabetics with neuropathy but no diarrhoea and a group with "diabetic diarrhoea" were compared with those in a group of stable, uncomplicated diabetics. The diabetics with neuropathy had significantly more dihydroxy bile salts, a larger bile-salt pool, and a higher faecal excretion of bile than the controls. The diabetics with diarrhoea had significantly more dihydroxy bile salts, a higher glycine to taurine ratio, a smaller bile-salt pool, and increased excretions of 14C-tracer and total bile salts. We conclude that considerable alterations occur in the bile of diabetics with neuropathy or diarrhoea, and we suggest that in some cases at least these abnormalities may indicate a mechanism for diabetic diarrhoea.
The Psychosomatic Approach in Medical Therapy
Authors: Franz Alexander
Journal: Psychotherapy and Psychosomatics (1954)

Research Articles| January 20 2010 The Psychosomatic Approach in Medical Therapy Subject Area: Psychiatry and Psychology Franz Alexander Franz Alexander Chicago Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1954) 2 (3-4): 284–300. https://doi.org/10.1159/000278439 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Franz Alexander; The Psychosomatic Approach in Medical Therapy. Acta Psychotherapeutica et Psychosomatica 31 December 1954; 2 (3-4): 284–300. https://doi.org/10.1159/000278439 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1954Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Overexpression of microRNA-1 impairs cardiac contractile function by damaging sarcomere assembly
Authors: Jing Ai, Rong Zhang, Xu Gao, Hui-Fang Niu, Ning Wang, Yi Xu, Yue Li, Ning Ma, Li-Hua Sun, Zhen-Wei Pan, Wei-Min Li, Bao-Feng Yang
Journal: Cardiovascular Research (2012)

AimsThe purpose of the present study was to evaluate the effects of overexpression of microRNA-1 (miR-1) on cardiac contractile function and the potential molecular mechanisms.
Neurogenetic determinism and the new euphenics
Authors: S. P R Rose
Journal: BMJ (1998)

As we approach the end of what in the United States has been termed the decade of the brain, and with a complete map of the human genome in sight, it may be time to try to re-evaluate what the vast increase in molecular knowledge of brain processes has achieved.

Certainly there has been no shortage of claims. The abnormal genes and their protein products associated with neurodegenerative diseases such as Huntington's chorea have been identified. Genetic risk factors for Alzheimer's disease are known, and the molecular processes which culminate in the devastating neuronal death and malfunction that are responsible for the disease are subject to intense investigation. However, for neither of these conditions has the new genetic knowledge brought—yet—any effective treatment or prevention. Of course it may come, although not, as many of the advocates of the new genetics once promised, as a result of genetic engineering, but rather because the increased biochemical understanding that follows from genetic information may help in constructing more precisely targeted drugs. Indeed, the best pointer to neuroprotection against Alzheimer's disease has come from epidemiological evidence of the protective effect of hormone replacement therapy in older women rather than from molecular studies.

### Summary points

Genes have been identified for several neurodegenerative diseases, but so far this has not led to effective treatment

The tendency to view the complexities of human behaviour as genetically determined has important consequences

One is the construction of new diseases—for example, disruptive children are diagnosed as having attention deficit hyperactivity disorder and are prescribed methyphenidate hydrochloride

Another is that social problems such as violence and alcoholism can be regarded …
Diffuse Simple Erosions in a Neonate
Authors: Christina Boull, Holly Hanson, Ingrid Polcari
Journal: JAMA Dermatology (2014)

Thepediatricdermatology teamwascalled to theneonatal intensive careunit toevaluate a full-termmalenewbornwithdiffuseerosions present at birth. On examination, 1to 4-mm simple erosions were noted over the scalp, face, trunk, scrotum, limbs, palms, and soles (Figure, A). Vital signs and findings from the remainder of the physical examination were normal. The patient’s mother had a normal pregnancy. She was immune to rubella; negative for hepatitis B, human immunodeficiency virus, group B streptococcus, and syphilis; and had no history of genital herpes. She reported exposure to a relative who had chicken pox during the first trimester of her pregnancy. Atbirth the infantwas transferred to theneonatal intensivecare unitandwasstartedontherapywithbroad-spectrumantibioticsand acyclovir forapresumedcongenital infection.Woundandbloodbacterial and viral cultures were negative. A skin biopsy specimenwas obtainedandevaluatedwithhematoxylin-eosin (Figure, B) and immunostaining (Figure, C). What is your diagnosis?
A cluster of mutations in the D3 domain of von Willebrand factor correlates with a distinct subgroup of von Willebrand disease: type 2A/IIE
Authors: Reinhard Schneppenheim, Jan Jacques Michiels, Tobias Obser, Florian Oyen, Antje Pieconka, Sonja Schneppenheim, Kerstin Will, Barbara Zieger, Ulrich Budde
Journal: Blood (2010)
Why has so little changed in maternal and child health in south Asia?
Authors: Z. A Bhutta
Journal: BMJ (2000)

> “Fate has allowed humanity such a pitifully meagre coverlet that in pulling it over one part of the world, another has to be left bare”

Rabindranath Tagore, who won the Nobel Prize for literature in 1913, uttered these prophetic words almost a century ago.1 He might have said this as he witnessed the plight of the starving multitudes in Bengal. As I write this piece at the turn of the new millennium, I am painfully aware of the masses of people in western India and Pakistan who are caught once again in the grips of an unprecedented drought and an acute shortage of food. Yet, while much has remained unchanged, in many ways the subcontinent has made tremendous strides since securing independence almost 50 years ago. It boasts a modern industrial infrastructure; globally, it exports the bulk of people with expertise in computer software and information technology; and it has nuclear weapons capability. But recent policies of structural adjustment have led to an increase in poverty and social inequity and comparatively few resources have been allocated to health care and health related research.2 In south Asia, especially in India and Pakistan, indicators of the health of mothers and children remain poor, and statistics on health and nutrition in the area rank among the worst in the world (table 1).3-6

#### Summary points

Despite south Asia's nuclear capability and technological skills, indicators of maternal and child health rank among the worst in the world

The health of mothers and children is intertwined with the poor status of women in society and with economic inequity

Few research programmes are aimed at understanding and tackling the basic determinants of health, and there is little applied research

Funds available for health care and health related research are limited and subject to structural adjustments …
Management of gastroenteritis at home
Authors: J Quarrie
Journal: BMJ (1981)

Due to other ont0odMes 1969 1974 1980 Cases of haemolytic disease of the newborn due to anti-D (newly immunised only) and other irregular antibodies in the Odense area 1969-80.Prophylactic treatment with immunoglobulin anti-D started in March 1970.The numbers are: 1969 (total births
Phenothiazines and Sudden Death
Authors: Mary E. Granger
Journal: JAMA (1965)

<h3>To the Editor:—</h3> In his rebuttal of the Hollister and Kosek paper ("Sudden Death During Treatment with Phenothiazine Derivatives,"<b>192</b>:1035, 1965) Blachly (<b>193</b>:628, 1965) draws attention to what may well be a significant fact. Death in three patients (cases 2, 5, and 6) appears to have occurred several days after<i>reduction</i>in dosage of the phenothiazine and in a fourth (case 4) there was a strong possibility that a similar situation existed. Drs. Hollister and Kosek deduce that these deaths were connected with their phenothiazine therapy and Dr. Blachly's retort is that if cardiac arrhythmia occurred "and if it were due to the phenothiazine drug, would one not expect it to occur when the drug was increased?" in dosage of these drugs. Of further interest in this regard is the case Dr. Blachly mentions, where phenothiazines used following open-heart surgery was "stopped prematurely" and "a ventricular fibrillation developed 12 hours after the last dose.
THE PROBLEM OF ACCIDENTAL POISONING IN CHILDHOOD
Authors: JOHN AIKMAN
Journal: JAMA (1934)

Toxicology as it has been taught in medical schools has chiefly considered poisons in relation to homicide and suicide and as poisoning occurs in industrial medicine. Less attention is given to accidental poisonings. Textbooks on pediatrics have but little to say regarding accidental poisonings as a problem in diagnosis and treatment in children. Yet poisons are a real menace to the children of this country, as can be shown by hospital records and mortality statistics. These figures do not show nonfatal cases, those cases never seen by physicians, and those in which treatment was given but not placed on record. The experience of every pediatrician proves that poisonings are not infrequent in children. It is also obvious that such cases may not be recognized. Individual physicians see but few cases of any one poisoning, such as strychnine, but in the aggregate the cases amount to a total that goes far
Endoscopical Observation of the Gastric Ulcer
Authors: K. Kawai, K. Murakami, F. Misaki
Journal: Endoscopy (1969)

195 round ulcers were examined once a month at least for the first three months. 152 healed keeping their original round shape (α course). 31 showed a short linear niche meeting at right angles with the lesser curvature (β course). 9 ulcers splitted into kissing ulcer (γ course) and 3 cases of a giant ulcer of the body of the stomach showed a linear niche in parallel to the lesser curvature (δ course). Ulcers taking the β or γ course are more apt to relapse. As far as the pathogenesis of the linear ulcer is concerned there are three patterns of development. 15% of all round ulcers are prone to heal in a linear fashion. In addition linear ulcers may be derived from the confluence of multiple ulcers and finally, a giant ulcer may become gradually linear as the mucous membrane around the ulcer covers its surface.