tbuckley/cabot-search huggingface dataset:
Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome
Authors: Kirk Mykytyn, Darryl Y. Nishimura, Charles C. Searby, Mythreyi Shastri, Hsan-jan Yen, John S. Beck, Terry Braun, Luan M. Streb, Alberto S. Cornier, Gerald F. Cox, Anne B. Fulton, Rivka Carmi, Güven Lüleci, Settara C. Chandrasekharappa, Francis S. Collins, Samuel G. Jacobson, John R. Heckenlively, Richard G. Weleber, Edwin M. Stone, Val C. Sheffield
Journal: Nature Genetics (2002)
Patient characteristics associated with care by a cardiologist among adults hospitalized with severe congestive heart failure
Authors: Andrew D Auerbach, Mary Beth Hamel, Robert M Califf, Roger B Davis, Neil S Wenger, Norman Desbiens, Lee Goldman, Humberto Vidaillet, Alfred F Connors, Joanne Lynn, Neal V Dawson, Russell S Phillips
Journal: Journal of the American College of Cardiology (2000)
Immunopathologic study of lichenoid skin diseases: Correlation between HLA-DR-positive keratinocytes or Langerhans cells and epidermotropic T cells
Authors: Tetsuo Shiohara, Noriko Moriya, Yukiko Tanaka, Yoshiko Arai, Jun Hayakawa, Machiko Chiba, Masaji Nagashima
Journal: Journal of the American Academy of Dermatology (1988)
Blocking Lipid Synthesis Overcomes Tumor Regrowth and Metastasis after Antiangiogenic Therapy Withdrawal
Authors: Nor Eddine Sounni, Jonathan Cimino, Silvia Blacher, Irina Primac, Alice Truong, Gabriel Mazzucchelli, Alexandra Paye, David Calligaris, Delphine Debois, Pascal De Tullio, Bernard Mari, Edwin De Pauw, Agnes Noel
Journal: Cell Metabolism (2014)
Treatment of thyroid cysts by aspiration and injection of sclerosant.
Authors: C J Edmonds, M Tellez
Journal: BMJ (1987)

Postneonatal mortality in England and Wales in 1950Wales in , 1960Wales in , and 1970-84, in -84, in northern (-@*) and southern (O---O) regions.and is the best indicator of a nation's health and social progress.Concern about geographical differences in postneonatal mortality was expressed in the Court and Black reports.These geographical differences no longer exist; thus one inequality in health has been conquered.We believe that equality has been reached through the disappearance ofdeaths from infections of the respiratory and gastrointestinal tracts, since 1960 in southern regions and since 1975 in northern regions.Baird showed that in the north of England in the past a higher proportion of children were reared in poor and polluted environments with consequent lowering of the reproductive efficiency of future generations.5This effect may also explain why the fall in postneonatal mortality in northern regions was delayed for 15 years.The reports ofBarker and Osmond generally support this concept in suggesting that attempts to lower mortality and improve health in adults must start in childhood.23 1 Barker DJP.Geographical variations in disease in Britain.
THE RELATION OF ETHYL ALCOHOL TO THE NUTRITION OF THE ANIMAL BODY.
Authors: WINFIELD S. HALL
Journal: JAMA (1900)

Within the past year much has been said and written about alcohol. The daily press, the school periodicals and the medical journals have abounded in articles treating of various phases of the alcohol question. Professor Atwater's calorimeter experiments and his arraignment of the school text-books, together with the controversy regarding the army canteen, have reopened afresh questions which were supposed to be practically settled. Most extended and trustworthy experiments have been performed in respiration-calorimeters by numerous investigators in Europe, and several European governments have made exhaustive experiments with alcohol in their armies; but a scientific question is never settled as long as new evidence is forthcoming, and all fair-minded people are open to conviction on all controversial questions. The writer brings report of no new experiments; but attempts simply to discuss work done by others and to determine from these almost innumerable experiments and observations the relation of ethyl alcohol
Transport of free fatty acid and triglyceride in anhepatic rats
Authors: Steven H. Quarfordt, Eliana Defaria, Barry A. Landis, Randal R. Bollinger, Yasuo Yamaguchi
Journal: Hepatology (1991)

Without a liver the fractional plasma removal of free fatty acid is one third and chylomicron triglyceride one half of that in the intact rat. The intestine of the anhepatic rat converted enteral fatty acid to plasma triglyceride but was unable to do the same for plasma free fatty acid. This decrease in plasma free fatty acid removal and the inability to recycle the acid as triglyceride were, in part, responsible for the conversion of large fractions of plasma triglyceride flux to the plasma free acid in hepatectomized rats. Increased intravascular triglyceride lipolysis resulting from high circulating lipoprotein lipase concentrations and reduced plasma triglyceride removal were other factors shifting the partition of anhepatic plasma fatty-acid transport from the ester to the free. After the anhepatic plasma clearance of either free fatty acid or triglyceride, relatively more of both compounds was recovered in the lipid of actively metabolizing (heart and muscle) as opposed to storage (adipose) tissue when compared with controls. Sequential evaluations of the recovery of plasma free fatty acid and triglyceride in tissues of anhepatic rats demonstrated accumulation or storage solely in adipose tissue and only when the plasma fatty acid was in triglyceride. This observation and the large conversion of anhepatic circulating triglyceride to the free acid may, in part, explain the lack of an increase in adipose lipid with reduced hepatic mass. The data help explain the preferential use of a lipid fuel in liver disease and the difficulties in obtaining carbon storage in this condition.
Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease
Authors: A Keshavarzian
Journal: Gut (2003)

<b>Background:</b> Overproduction of colonic oxidants contributes to mucosal injury in inflammatory bowel disease (IBD) but the mechanisms are unclear. Our recent findings using monolayers of intestinal cells suggest that the mechanism could be oxidant induced damage to cytoskeletal proteins. However, oxidants and oxidative damage have not been well characterised in IBD mucosa. <b>Aims:</b> To determine whether there are increases in oxidants and in tissue and cytoskeletal protein oxidation in IBD mucosa. <b>Methods:</b> We measured nitric oxide (NO) and markers of oxidative injury (carbonylation and nitrotyrosination) to tissue and cytoskeletal proteins in colonic mucosa from IBD patients (ulcerative colitis, Crohn’s disease, specific colitis) and controls. Outcomes were correlated with IBD severity score. <b>Results:</b> Inflamed mucosa showed the greatest increases in oxidants and oxidative damage. Smaller but still significant increases were seen in normal appearing mucosa of patients with active and inactive IBD. Tissue NO levels correlated with oxidative damage. Actin was markedly (&gt;50%) carbonylated and nitrated in inflamed tissues of active IBD, less so in normal appearing tissues. Tubulin carbonylation occurred in parallel; tubulin nitration was not observed. NO and all measures of oxidative damage in tissue and cytoskeletal proteins in the mucosa correlated with IBD severity. Disruption of the actin cytoarchitecture was primarily within the epithelial cells and paracellular area. <b>Conclusions:</b> Oxidant levels increase in IBD along with oxidation of tissue and cytoskeletal proteins. Oxidative injury correlated with disease severity but is also present in substantial amounts in normal appearing mucosa of IBD patients, suggesting that oxidative injury does not necessarily lead to tissue injury and is not entirely a consequence of tissue injury. Marked actin oxidation (&gt;50%)—which appears to result from cumulative oxidative damage—was only seen in inflamed mucosa, suggesting that oxidant induced cytoskeletal disruption is required for tissue injury, mucosal disruption, and IBD flare up.
The 11482G&amp;gt;A Polymorphism in the Perilipin Gene Is Associated With Weight Gain With Rosiglitazone Treatment in Type 2 Diabetes
Authors: Eun Seok Kang, Bong Soo Cha, Hyeong Jin Kim, Hae Jin Kim, So Hun Kim, Kyu Yeon Hur, Hyun Joo Lee, Wan Sub Shim, Chul Woo Ahn, Hyun Chul Lee
Journal: Diabetes Care (2006)

The aim of this study was to examine the effects of perilipin gene (PLIN) polymorphisms on weight gain with rosiglitazone treatment in patients with type 2 diabetes.A total of 160 type 2 diabetic patients were treated with rosiglitazone (4 mg/day) for 12 weeks in addition to their previous medications, which were unchanged. Four single nucleotide polymorphisms (SNPs) at the PLIN locus were genotyped: PLIN 6209T>C, PLIN 11482G>A, PLIN 13041A>G, and PLIN 14995A>T.Although fasting plasma glucose and HbA(1c) levels decreased; mean body weight increased significantly after rosiglitazone treatment. Among the four SNPs tested, only the PLIN 11482G>A polymorphism was associated with weight gain from rosiglitazone treatment. In addition, there was a significant difference in the increase in the body weight among the genotypes. Patients with the 11482A/A genotype showed less increase in body weight than those with other genotypes.These data suggest that genetic variations in the perilipin gene can affect weight gain associated with rosiglitazone treatment in patients with type 2 diabetes.
Faster Brain Shrinkage in the ACCORD MIND Study—Reply
Authors: Jeff D. Williamson, Lenore J. Launer, Michael E. Miller
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Why Patients Enroll In Clinical Trials: Physicians Play A Key Role
Authors: Caroline McNeil
Journal: JNCI Journal of the National Cancer Institute (1996)

News News be played back later, from the viewpoint of each participant, he said.There probably are about 100 "serious" MOOs (as opposed to purely social ones) said Remy Evard, manager of advanced computing and networks at Argonne."Most are private, behind a company firewall or limited to a small number of people."Only about five research-oriented MOOs exist to Evard's knowledge, including BioMOO, which caters to environmental researchers, so far there is no MOO for cancer researchers."The cancer community as a whole doesn't use this technology yet," said Evard.Getting a MOO started requires a lot of administration, noted Stevens.Cancer researchers probably wouldn't want to maintain it, "but they could talk to us about getting access to part of the world we already run," he said.A certain social milieu is needed to establish a MOO, said Evard."There are probably two reasons you would go, one, if there was a known expert you could talk to, or to hear a talk, or otherwise gain access to knowledge.The other is if your collaborator was there."As a resource for researchers, the internet is a rapidly moving target.Keep an eye on this space.
Are We Doing Better with Large-Bowel Cancer?
Authors: Jerome J. DeCosse
Journal: New England Journal of Medicine (1984)

AS the second leading cause of death from neoplasia, large-bowel cancer commands the attention of many kinds of physicians. Although the treatment of large-bowel cancer has historically been, and still is, surgical, today gastroenterologists, radiation therapists, medical oncologists, immunologists, family physicians, and pathologists are also committed to preventing, treating, and learning about this disease. In this issue of the Journal, the Gastrointestinal Tumor Study Group (GITSG)1 reports the results of a careful randomized study of patients with colon cancer. They found no benefit when patients were treated with adjuvant chemotherapy with fluorouracil and semustine, nonspecific immunotherapy with the methanol . . .
Downregulation of Cytoskeletal Muscle LIM Protein by Nitric Oxide
Authors: Jörg Heineke, Tibor Kempf, Theresia Kraft, Andres Hilfiker, Henning Morawietz, Robert J. Scheubel, Pico Caroni, Suzanne M. Lohmann, Helmut Drexler, Kai C. Wollert
Journal: Circulation (2003)

Background— In chronic heart failure, myocardial expression of the inducible isoform of nitric oxide (NO) synthase (NOS2) is enhanced, leading to a sustained production of NO. We postulated that NO modulates expression of genes in cardiac myocytes that may be functionally important in the context of cardiac hypertrophy and failure. Methods and Results— As revealed by cDNA expression array analyses, the NO donor SNAP, which has been shown previously to inhibit agonist-induced cardiac myocyte hypertrophy, downregulates expression of the cytoskeleton-associated muscle LIM protein (MLP) in endothelin-1 (ET-1)–stimulated neonatal rat cardiac myocytes. Northern blotting and immunoblotting experiments confirmed this finding and established that SNAP negatively controls MLP mRNA (−49%, P &lt;0.01) and protein (−52%, P &lt;0.01) abundance in ET-1–treated cardiomyocytes via cGMP-dependent protein kinase and superoxide/peroxynitrite-dependent signaling pathways. Treatment of cardiac myocytes with IL-1β and IFN-γ downregulated MLP expression levels via induction of NOS2. Moreover, expression levels of NOS2 and MLP were inversely correlated in the failing human heart, indicating that NOS2 may regulate MLP abundance in vitro and in vivo. Antisense oligonucleotides were used to explore the functional consequences of reduced MLP expression levels in cardiac myocytes. Like SNAP, antisense downregulation of MLP protein expression (−52%, P &lt;0.01) blunted the increases in protein synthesis, cell size, and sarcomere organization in response to ET-1 stimulation. Conversely, overexpression of MLP augmented cell size and sarcomere organization in cardiac myocytes. Conclusions— NO negatively controls MLP expression in cardiac myocytes. Because MLP is necessary and sufficient for hypertrophy and sarcomere assembly, MLP downregulation may restrain hypertrophic growth in pathophysiological situations with increased cardiac NO production.
THE ROENTGEN DEMONSTRATION OF CALCIFIED CORONARY ARTERIES IN LIVING SUBJECTS
Authors: PAUL H. WOSIKA
Journal: JAMA (1934)

Pericardial calcification has been demonstrated roentgenographically in living patients by many authors. Calcification in the myocardium, in cardiac aneurysms, in cardiac thromboses and in tumors has been shown in postmortem specimens. In a previous communication we<sup>1</sup>summed up all the previously reported cases of endocardial calcification together with those in the annulus fibrosus and added twenty-three cases, all demonstrated in living patients. The total number of these in our files is now forty-five, several of which have been confirmed by the pathologist. It has been said by many roentgenologists writing on the subject of calcification in the heart that calcified coronary arteries should be demonstrable in the living patient but that this discovery must wait for refinements in technic and improvements in x-ray equipment. Recently Roesler,<sup>2</sup>in a review of the roentgen interpretation of cardiovascular disease, said: "Calcification of the coronary arteries will undoubtedly be shown in the
Sports Medicine: Fitness, Training, Injuries
Authors: Bruno Balke
Journal: JAMA (1989)

This book was received for review with high expectations since millions of people have become active in recreational and competitive sports and almost all of them need some advice on how to train safely as well as efficiently. Most adequate advice comes from physicians, physiologists, coaches, physical educators, psychologists, trainers, etc, who have themselves been active in diverse sports and thus have become familiar with aspects of physical conditioning, training, and prevention of and rehabilitation from injuries. If this book was intended to serve as a text for a graduate course in sports medicine, it falls somewhat short of that purpose. It starts out with a not quite pertinent introduction by Dr Ernst Jokl, who from his longtime sports-medical background could have provided historic aspects of the development of sports medicine as it is understood today. In the book's contents the authors follow closely the outlines used in Professor A.
The Treatment of Scabies
Authors: R. Liveing
Journal: BMJ (1875)

of after-vomiting, and, in ovariotomy, from the chance of losing their lives in certain cases of bad adhesion from bleeding being set up by the sickness after the abdomen is closed.WVhether of itself it diminishes the risk of operations, I cannot tell; but I am inclined to think that it does often save the feeble ones.This much I can say, that ether has now been given in one hundred and thirty-five cases of ovariotomy, and in two cases of successful removal of the uterus for fibro-cystic tumour.In every case, the anaesthesia was profound, many of the operations were very tedious, and, of the last sixty-six operated on, sixty have recovered.
"Normal" acute phase response in systemic sclerosis.
Authors: M Chellingsworth, D G Scott, P A Crockson, P A Bacon
Journal: BMJ (1984)

An Italian woman with classic active progressive systemic sclerosis had a normal serum concentration of C reactive protein (less than 6 mg/1). During an infection with Staphylococcus aureus, however, the concentration rose to 250 mg/1. This was unexpected, since in scleroderma the acute phase response to infection (a brisk rise in serum concentrations of various proteins, including C reactive) has been thought to be defective. This patient is evidence that the acute phase response does occur in systemic sclerosis and that probably it is the nature of the primary disease that masks the response in some cases.
Help for Papua New Guinea Library
Authors: A. C. BUTLER
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 December 1978Help for Papua New Guinea LibraryA. C. BUTLERA. C. BUTLERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-1013_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: When the readers of your journal were students, they almost certainly had access to a well-stocked biomedical library on campus. Their information needs, as graduate physicians, have altered but not necessarily diminished. Whether they are studying for board certification, undertaking a piece of research for publication, or simply following-up an interesting case, they will probably call on a medical library at some stage.Most medical school libraries in the developed world have a stock of 30 000 books or more. In addition, they are likely to have the support of other biomedical libraries within reach either physically... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. C. BUTLERAffiliations: University of Papua New Guinea Port Moresby, Papua New Guinea PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1978Volume 89, Issue 6Page: 1013-1013KeywordsGraduate medical educationLibraries ePublished: 1 December 2008 Issue Published: 1 December 1978 PDF downloadLoading ...
TCT-616 Comparison of Long-Term Outcomes with Everolimus-Eluting- and Sirolimus-Eluting Stents in Small Coronary Artery Disease
Authors: Hironori Kitabata, Joshua Loh, Gabriel Sardi, Salem Badr, Danny Dvir, Israel Barbash, Rebecca Torguson, Kenneth Kent, Lowell Satler, William Suddath, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2012)
Regulatory T-cell Patterns and Cytokine Profiles Suggest the Development of Tolerance in Patients Undergoing Peanut Oral Immunotherapy (OIT)
Authors: J.A. Bird, A.M. Scurlock, T.T. Perry, S.M. Jones, L.A. Pons, M.D. Kulis, A.W. Burks
Journal: Journal of Allergy and Clinical Immunology (2009)
703. Analysis of the Stability and Functionality of siRNA after Nebulization of siRNA Polyplexes
Authors: Stephanie Huth, Christa Schmidt, Carsten Rudolph, Joseph Rosenecker
Journal: Molecular Therapy (2006)

Aerosol application of siRNA is a promising therapeutical approach to reach and silence genes which are leading to diseases of the lung, e. g. Cystic fibrosis (CF). Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) are leading to a missing down regulation of the epithelial sodium channel (ENaC) which results in an increased absorption of sodium ions and fluid across the airway epithelia leading to the depletion of the perciliary liquid layer and to the depression of mucus clearance. Therefore silencing ENaC by RNA interference might help to treat this disease. The integrity of the siRNA nebulized is a precondition for this new approach. In this work, we studied the properties of siRNA polyplexes after the nebulization process. In particular, we analyzed its stability and functionality before and after nebulization. The physical stability of siRNA was studied by polyacrylamide gel electrophoresis. Its functionality was analyzed in vitro by determining the efficiency of silencing by flow cytometry using cells stably expressing GFP and siRNA against GFP. We investigated the siRNA properties of complexes based on different non-viral vectors e.g. polyethylenimine (PEI) and Oligofectamine™. Our data shows that complexed siRNA unlike to naked siRNA is not harmed by the nebulization process. After the nebulization process the complexes are still able to down regulate the GFP expression. In conclusion, aerosol application is an appropriate method for siRNA delivery.