Blood Alcohol Levels after Prolonged Histamine-2-Receptor Antagonist Treatment
Authors: Alessandro Cassini
Journal: Annals of Internal Medicine (1994)

Letters1 January 1994Blood Alcohol Levels after Prolonged Histamine-2-Receptor Antagonist TreatmentAlessandro Cassini, MD, Franceso Mari, PhD, and Calogero Surrenti, MDAlessandro Cassini, MDUniversita di Firenze; Firenze, ItalySearch for more papers by this author, Franceso Mari, PhDUniversita di Firenze; Firenze, ItalySearch for more papers by this author, and Calogero Surrenti, MDUniversita di Firenze; Firenze, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-1-199401010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Recent studies indicate that cimetidine and ranitidine, but not famotidine, may inhibit gastric alcohol-dehydrogenase activity, thus impairing the gastric first-pass metabolism of ethanol [1-4]. Those studies, however, were done in “artificial” conditions (healthy patients; 1 week of treatment; last dose at breakfast, 1 hour before alcohol ingestion). We studied whether prolonged treatment with ranitidine or famotidine affected blood alcohol concentrations in 16 men with duodenal ulcers. Patients with Helicobacter pylori-associated duodenal ulcers were not enrolled [5]. Patients were randomly assigned to receive either 300 mg of ranitidine (n = 8) or 40 mg of famotidine (n = ...References1. Julkunen RJ, DiPadova C, Lieber CS. First pass metabolism of ethanol: a gastrointestinal barrier against the systemic toxicity of ethanol. Life Sci. 1985; 37:567-73. Google Scholar2. Hernandez-Mugnoz R, Caballeria J, Baraona E, Uppal R, Greenstein R, Lieber CS. Human gastric alcohol dehydrogenase: its inhibition by H2-receptor antagonists, and its effect on the bioavailability of ethanol. Alcohol Clin Exp Res. 1990; 14:946-50. Google Scholar3. Caballeria J, Baraona E, Deulofeu R, Hernandez-Munoz R, Rodes J, Lieber CS. Effects of H2-receptor antagonists on gastric alcohol dehydrogenase activity. Dig Dis Sci. 1991; 36:1673-9. Google Scholar4. DiPadova C, Roine R, Frezza M, Gentry RT, Baraona E, Lieber CS. Effects of ranitidine on blood alcohol levels after ethanol ingestion. JAMA. 1992; 267:83-6. Google Scholar5. Roine R, Salmela KS, Hook-Nikanne J, Kosunen TU, Salaspuro M. Alcohol dehydrogenase mediated acetaldehyde production by Helicobacter pylori. A possible mechanism behind gastric injury. Life Sci. 1992; 51:1333-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: Universita di Firenze; Firenze, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCimetidine and AlcoholRanitidine/famotidine interaction 1 January 1994Volume 120, Issue 1Page: 90KeywordsAlcoholsArea under the curveBlood alcohol concentrationDuodenal ulcersEthanolFamotidineIngestionOral administrationPatientsSpecimen preparation and treatment ePublished: 15 August 2000 Issue Published: 1 January 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...