tbuckley/cabot-search huggingface dataset:
Specialists question effectiveness of sex selection technique
Authors: S. Mayor
Journal: BMJ (2001)

Infertility specialists have expressed concern that media coverage of a technique claiming to virtually guarantee the sex of a fetus might have raised unrealistic expectations about its potential to prevent sex linked inherited conditions.

US researchers reported that the technique, which uses flow cytometry to separate sperm carrying X and Y chromosomes, was “unambiguous in assigning gender in 90 per cent of 284 embryos” in which it was used. Of these, 92% were female and 8% were male. When the group had previously carried out preimplantation genetic diagnosis, on embryos in which the sorting technique had not been used, they had found more or less equal numbers of male and …
Chinese herbal remedies may contain steroids
Authors: R A C Graham-Brown, J F Bourke, G Bumphrey
Journal: BMJ (1994)

Killer cell lectin-like receptor G1 (KLRG1) is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. KLRG1 is well conserved in mammals and is mostly expressed on subsets of T cells and natural killer (NK) cells. Upon binding to its ligands, N-cadherin and E-cadherin, the phosphatases SHP-2 and SHIP-1 are recruited to the cytoplasmic tail of KLRG1. Some studies have proposed that KLRG1 is a marker of senescence, while other studies suggest that KLRG1 is a marker of recently activated cells. In addition, although KLRG1 inhibitory potential has been established <i>in vitro</i>, it is unclear whether KLRG1 inhibits NK cells and CD8<sup>+</sup> T cells <i>in vivo</i>. To address its exact role, we have used CRISPR technology to generate mice deficient for KLRG1 and mice conditionally deficient for KLRG1 in the NK cell lineage. We found that NK cell frequency and number is not effected and that NK cell development is globally intact in KLRG1 deficient mice. The role of KLRG1 during viral infections and tumor development is currently being investigated.
Doctors on CBW-Two Views
Authors: HOWARD H. HIATT
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 January 1970Doctors on CBW-Two ViewsHOWARD H. HIATT, M.D.HOWARD H. HIATT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-1-143_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: My warm congratulations and gratitude for your editorial on chemical and biological warfare in the July 1969 issue of the ANNALS. As you so appropriately point out, we in the medical profession can no longer ignore our responsibility to take stands on issues that are simultaneously relevant to health and to public policy. There is clearly danger in the accelerating emphasis on military, rather than civilian decision-making. The editorial is a great service to medicine and to the country.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Beth Israel Hospital 330 Brookline Ave. Boston, Mass. 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1970Volume 72, Issue 1Page: 143-143KeywordsArmed forcesGratitudePrevention, policy, and public healthPublic policy Issue Published: 1 January 1970 PDF DownloadLoading ...
Reproductive and sexual health in adolescents with cystic fibrosis
Authors: S. M Sawyer
Journal: BMJ (1996)

cians, and since enrofloxacin, a related quinolone, was licensed for use in food producing animals in 1994.An antibiotic which could be of crucial importance in the management of some patients must be used with discretion by clinicians and veterinarians to ensure its continued usefulness.Large national epidemics begin small.Killelea et al are not the first to describe how the PHLS's laboratory surveillance of salmonellas has been well ahead in speedily identifying the source of outbreaks in Britain and elsewhere. 4 6-8Their paper, and the paper by Shohat et al, reminds us that there is a free market in salmonellosis; that international cooperation is essential; that identification and control depends on universal, not selective, surveillance and detailed typing of isolates including molecular methods; and that the PHLS's laboratory surveillance of salmonellosis is second to none.
EFFECTS OF LIGHT ON NORMAL RABBITS, WITH ESPECIAL REFERENCE TO THE ORGANIC REACTION
Authors: Louise Pearce, Chester M. Van Allen
Journal: The Journal of Experimental Medicine (1926)

A group of 50 normal male rabbits kept under conditions of constant light that had none of the shorter ultra-violet rays and another group kept in constant darkness for 2 to 12 weeks were observed clinically and subjected to postmortem examination for the purpose of determining the effect of these environmental conditions upon general body health and the weights of organs. A similar group of 50 rabbits caged in an ordinary animal room for the same period, and two groups of 40 and 20 rabbits respectively, which had recently been brought into the laboratory, served as controls. It was found that the general health of the rabbits was not impaired by the artificial light or the exclusion of light. The gain in body weight which occurred in all groups was especially marked in the case of those kept under conditions of constant light. The incidence of spontaneous disease recognizable clinically during the experiment was extremely low and of a mild character and did not obviously disturb the health of the animal. It was found at postmortem examination, on the other hand, that 59.3 per cent of the rabbits caged indoors, that is in the light, dark, or unaltered rooms, and 58.3 per cent of those recently brought to the laboratory had visible lesions of some kind. The great majority of these lesions, however, were of a slight grade, and none appeared to have any deleterious effects upon the general physical state of the animals.
Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.
Authors: D M Lublin, M K Liszewski, T W Post, M A Arce, M M Le Beau, M B Rebentisch, L S Lemons, T Seya, J P Atkinson
Journal: The Journal of Experimental Medicine (1988)

Membrane cofactor protein (MCP), a regulatory molecular of the complement system with cofactor activity for the factor I-mediated inactivation of C3b and C4b, is widely distributed, being present on leukocytes, platelets, endothelial cells, epithelial cells, and fibroblasts. MCP was purified from a human T cell line (HSB2) and the NH2-terminal 24-amino acid sequence obtained by Edman degradation. An oligonucleotide probe based on this sequence was used to identify a clone from a human monocytic (U937) cDNA library. Nucleotide sequencing showed a 43-bp 5'-untranslated region, an open reading frame of 1,152 bp, and a 335-bp 3'-untranslated region followed by a 16-bp poly(A) track. The deduced full-length MCP protein consists of a 34-amino acid signal peptide and a 350-amino acid mature protein. The protein has, beginning at the NH2 terminus, four approximately 60-amino acid repeat units that match the consensus sequence found in a multigene family of complement regulatory proteins (C3b-receptor or CR1, C3d-receptor or CR2, decay-accelerating factor, C4-binding protein, and factor H), as well as several other complement and non-complement proteins. The remainder of the MCP protein consists of 25 amino acids that are rich in serine and threonine (probable site of heavy O-linked glycosylation of MCP), 17 amino acids of unknown significance, and a 23-amino acid transmembrane hydrophobic region followed by a 33-amino acid cytoplasmic tail. The MCP gene was localized to human chromosome 1, bands 1q31-41, by analysis of human x rodent somatic cell hybrid clones and by in situ hybridization. This same genetic region contains the multigene family of complement-regulatory proteins, which is thereby enlarged to include the functionally and structurally related MCP.
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
Authors: Ross L. Levine, Martha Wadleigh, Jan Cools, Benjamin L. Ebert, Gerlinde Wernig, Brian J.P. Huntly, Titus J. Boggon, Iwona Wlodarska, Jennifer J. Clark, Sandra Moore, Jennifer Adelsperger, Sumin Koo, Jeffrey C. Lee, Stacey Gabriel, Thomas Mercher, Alan D’Andrea, Stefan Fröhling, Konstanze Döhner, Peter Marynen, Peter Vandenberghe, Ruben A. Mesa, Ayalew Tefferi, James D. Griffin, Michael J. Eck, William R. Sellers, Matthew Meyerson, Todd R. Golub, Stephanie J. Lee, D. Gary Gilliland
Journal: Cancer Cell (2005)
Achondrogenesis Type 1A — From Mouse to Human
Authors: Hudson H. Freeze
Journal: New England Journal of Medicine (2010)

In this issue of the Journal, Smits et al.1 describe how they identified the cause of a rare human skeletal dysplasia, achondrogenesis type 1A. In so doing, they have provided an excellent example of the interdependence between clinical medicine and basic science.One approach to better understanding rare neonatal lethal disorders is to genetically alter a model organism, such as the mouse. Genetic analysis can be done in forward or reverse directions. Reverse genetics involves mutating a specific gene and analyzing the resultant phenotype. Target genes are carefully chosen based on accumulated scientific information and the investigators' training, hypotheses, and . . .
Regarding “Time to Rethink Screening for Abdominal Aortic Aneurysm?”—Reply
Authors: Russell P. Harris, Stacey Sheridan, Linda Kinsinger
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Evaluating Iatrogenic Risk of Youth Suicide Screening Programs
Authors: Madelyn S. Gould, Frank A. Marrocco, Marjorie Kleinman, John Graham Thomas, Katherine Mostkoff, Jean Cote, Mark Davies
Journal: JAMA (2005)

Commission 1 and the Children's Mental Health Screening and Prevention Act 2 recommend increased screening for suicidality and mental illness.The recent enactment of the Garrett Lee Smith Memorial Act 3 further supports the development of youth suicide prevention and intervention programs.Despite the proliferation of screening programs in recent years (eg, Signs of Suicide, 4 Teen-Screen 5 ), the current debate about possible iatrogenic effects of other suicide preventive interventions, 6,7 and the belief that prevention programs may "spur troubled youngsters to try suicide," 8 the potential harm of screening for suicide remains unstudied. 9,10creening strategies are based on the valid premise that suicidal adolescents are underidentified [11][12][13][14][15] ; have an active, often treatable, mental illness [16][17][18] ; and exhibit identifiable risk factors. 11Evidence for the clinical validity and reliability of school-based screening procedures has recently emerged.Use of the Suicidal Ideation Questionnaire (SIQ) in a midwestern US high school yielded a sensitivity ranging from 83% to 100%, with specificity from 49% to 70%. 19The Suicide Risk Screen's use among 581 students in 7 high schools had a sensitivity ranging from 87% to 100%, with specificity from 54% to 60%. 20Among 2004 teenagers from 8 New York metropoli-
Microheterogeneity of alpha 1 acid glycoprotein in rheumatoid arthritis: dependent on disease duration?
Authors: P Hrycaj, M Sobieska, S Mackiewicz, W Muller
Journal: Annals of the Rheumatic Diseases (1993)

The microheterogeneity of alpha 1 acid glycoprotein (AGP) was studied using affinity immunoelectrophoresis with concanavalin A (Con A) in serum samples of 43 patients with early rheumatoid arthritis (RA) without clinical features of intercurrent infection. The results were expressed as reactivity coefficients. Disease activity was measured by clinical (Lansbury's joint index, Mallya-Mace activity score) and laboratory (erythrocyte sedimentation rate, levels of soluble interleukin-2 receptor, C reactive protein, and AGP) indices. In contrast with previous reports, suggesting a decrease in AGP-Con A reactivity in patients with RA, high values of AGP reactivity coefficients were found in patients with disease of short duration, which were similar to those found in patients with acute bacterial infections. Conversely, normal or decreased values of AGP reactivity coefficients were found in patients with disease of longer duration. Regression analysis showed a significant relation between AGP reactivity coefficients and disease duration (multiplicative model). No other indices examined were significantly related to disease duration. These results, taken together with previous findings suggesting that cytokines control the glycosylation of acute phase proteins, indicate that differences in the microheterogeneity of AGP in early and longstanding RA reflect differences in cytokine action at different stages of the disease.
Contemporary Concepts of the Pathogenesis and Management of Preeclampsia
Authors: Kristine Y. Lain
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proposed Card, Intended to Facilitate Medical Billing, Record Keeping, Draws Mixed Reviews
Authors: Paul Cotton
Journal: JAMA (1991)

ELECTRONIC SYSTEMS designed to cut health insurance red tape are, with caveats on confidentiality, generally thought to be a good way to reduce costs and hassles for patients and providers. However, a proposal this month by Department of Health and Human Services Secretary Louis Sullivan, MD, to give every insured person a credit card that would facilitate electronic billing and record keeping by containing the details of what the patient is and is not covered for, and to then call that a first step in health care reform, seems mostly to be fueling criticism of the Bush administration's approach to such reform. "Not that it is a bad idea," says Sidney Wolfe, MD, director of Public Citizen Health Research Group, Washington, DC, but the potential savings "are a drop in the bucket of administrative waste. This does not improve access, it improves cash flow," he says. The plan is "a
Uptake of FDG in the Area of a Recently Implanted Bioprosthetic Mitral Valve
Authors: Aiden Abidov, Alessandro D’agnolo, Sean W. Hayes, Daniel S. Berman, Alan D. Waxman
Journal: Clinical Nuclear Medicine (2004)

A 74-year-old woman with history of melanoma, left breast cancer and status post left mastectomy, underwent FDG PET scanning as a part of a pulmonary nodule assessment. Two months before the scan the patient had undergone mitral valve replacement using a Hancock-2 porcine prosthesis due to severe mitral regurgitation. The PET scan demonstrated a circular rim of activity in the region of the mitral valve, but was otherwise negative. Additional workup to exclude a possible infectious process of the valve prosthesis was negative. The finding is most likely secondary to a nonspecific postsurgical inflammatory response in the area of the recently implanted artificial valve.
Land use and transportation issues in environmental control.
Authors: S D Liff, S J Bellomo
Journal: Environmental Health Perspectives (1975)

Analyses have been made of the effects of environmental controls and planning at regional, subarea, and project levels. The results obtained at the regional level are reviewed for a proposed highway development around Baltimore, Md. The findings for both short-term and long-term effects of alternative transport policies are summarized in respect of population and employment, economic indicators, traffic and travel, air quality, water and solid waste, noise, and environmentally sensitive areas. Problems at subarea and project levels are briefly considered.
The percutaneous penetration of nandrolone decanoate*
Authors: M.I. FOREMAN, I. CLANACHAN
Journal: British Journal of Dermatology (1975)

A study has been carried out on the penetration of nandrolone decanoate through human cadaver skin in vitro using radioactive tracer material. The radiochemical purity of the material desorbed from the dermal skin surface is very much less than that of the material absorbed into the epidermal surface. These observations are a consequence of the low level of overall penetration of the skin by the steroid. There is also a possibility that a small percentage of the steroid is being metabolized by micro-organisms present in the skin samples.
Northern Exposure -- Can the United States Learn from Canada?
Authors: Allan S. Detsky
Journal: New England Journal of Medicine (1993)

This issue of the Journal contains two papers that are likely to fuel the debate over the appropriateness of Canada's universal single-payer health insurance system as a model for Americans. Redelmeier and Fuchs1 show that American acute care hospitals use 24 percent more resources per admission than Canadian hospitals. In attempting to explain the greater expenditures in the United States, these investigators could not support the hypothesis that American patients receive more services per admission, although their investigation was limited to 12 diagnostic services in two pairs of hospitals in California and Ontario. They tentatively conclude that the 24 percent . . .
Perspectives of Canadian Stakeholders on Criteria for Appropriateness for Total Joint Arthroplasty in Patients With Hip and Knee Osteoarthritis
Authors: Gillian Hawker, Eric R. Bohm, Barbara Conner‐Spady, Carolyn De Coster, Michael Dunbar, Allan Hennigar, Lynda Loucks, Deborah A. Marshall, Marie‐Pascale Pomey, Claudia Sanmartin, Tom Noseworthy
Journal: Arthritis & Rheumatology (2015)

As rates of total joint arthroplasty (TJA) for osteoarthritis (OA) rise, there is a need to ensure appropriate use. We undertook this study to develop criteria for appropriate use of TJA.In prior work, we used qualitative methods to separately assess OA patients' and arthroplasty surgeons' perceptions regarding appropriateness of patient candidates for TJA. The current study reviewed the appropriateness themes that emerged from each group, and a series of statements were developed to reflect each unique theme or criterion. A group of arthroplasty surgeons then indicated their level of agreement with each statement using electronic voting. Where ≤70% agreed or disagreed, the criterion was discussed and revised, and revoting occurred. In standardized telephone interviews, OA patient focus group participants indicated their level of agreement with each revised criterion.Qualitative research in 58 OA patients and 14 arthroplasty surgeons identified 11 appropriateness criteria. Member-checking in 15 surgeons (including 5 who had participated in the qualitative study) resulted in agreement on 6 revised criteria. These included evidence of arthritis on joint examination, patient-reported symptoms negatively impacting quality of life, an adequate trial of appropriate nonsurgical treatment, realistic patient expectations of surgery, mental and physical readiness of patient for surgery, and patient-surgeon agreement that potential benefits exceed risks. Thirty-six of the original 58 OA patient focus group participants (62.1%) participated in the member-check interviews and endorsed all 6 criteria.Patients and surgeons jointly endorsed 6 criteria for assessment of TJA appropriateness in OA patients. Prospective validation of these criteria (assessed preoperatively) as predictive of postoperative patient-reported outcomes is under way and will inform development of a surgeon-patient decision-support tool for assessment of TJA appropriateness.
Skin Signs of Systemic Disease.
Authors: Irwin M. Braverman
Journal: Annals of Internal Medicine (1982)

Cancer. Lymphomas and Allied Disorders. Leukemia and Allied Disorders. Histiocytosis X and Related Disorders. Dysproteinemias and Immunodeficiency Disorders. Amyliodosis. Connective Tissue (Rheumatic) Diseases. The Angiitides. Hypersensitivity Syndromes. Sarcoidosis. Blood Vessels. Diseases of the Gastrointestinal Tract. Endocrine and Metabolic Diseases. Connective Tissues. Neutrophilic Dermatoses. Pregnancy and the Menstrual Cycle. Nervous System. Infections.
Benign familial pemphigus responsive to cyclosporine, a possible role for cellular immunity in pathogenesis
Authors: A. D. Ormerod, Janet Duncan, L. Stankler
Journal: British Journal of Dermatology (1991)

Journal Article Benign familial pemphigus responsive to cyclosporine, a possible role for cellular immunity in pathogenesis Get access A. D. Ormerod, A. D. Ormerod Department of Dermatology, Aberdeen Royal Infirmary, Aberdeen AR9 2ZB, U.K. Search for other works by this author on: Oxford Academic Google Scholar Janet Duncan, Janet Duncan Department of Pathology, University of Aberdeen, Aberdeen, U.K. Search for other works by this author on: Oxford Academic Google Scholar L. Stankler L. Stankler Department of Dermatology, Aberdeen Royal Infirmary, Aberdeen AR9 2ZB, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 3, 1 March 1991, Pages 299–300, https://doi.org/10.1111/j.1365-2133.1991.tb00580.x Published: 01 March 1991
Limitations of current tuberculosis screening tests in immunosuppressed patients
Authors: V. Clifford, M. Tebruegge, N. Curtis
Journal: BMJ (2015)

We agree that a combination of an interferon γ release assay (IGRA; QuantiFERON-TB Gold in-Tube (QFT-IT) or TSPOT. TB ) and a tuberculin skin test is the most sensitive approach to screening for latent tuberculosis infection in patients with rheumatological diseases before starting biological drugs.1

The authors note that skin tests can be false-negative in patients receiving corticosteroids. However, IGRAs, which are designed primarily to achieve high …