Experimental Pyelonephritis and Hypertension
Authors: ALVIN P. SHAPIRO
Journal: Annals of Internal Medicine (1963)

Article1 July 1963Experimental Pyelonephritis and HypertensionImplications for the Clinical ProblemALVIN P. SHAPIRO, M.D., F.A.C.P.ALVIN P. SHAPIRO, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-37 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe relationships between pyelonephritis and hypertension in man have been debated since the studies of Longcope (1) and of Weiss and Parker (2). These investigators demonstrated that chronic pyelonephritis frequently was associated with hypertensive vascular disease and was seen in patients with accelerated nephrosclerosis in an especially high incidence. Perhaps particularly because these observations were made during an era of increasing concentration on the role of the kidney in the production of hypertension, it rapidly and generally was assumed that chronic pyelonephritis was an important primary cause. Subsequently, opinions about the relative etiologic importance of pyelonephritis in hypertension have ranged...References1. LONGCOPE WT: Chronic bilateral pyelonephritis: its origin and its association with hypertension. Ann. Intern. Med. 11: 149, 1937. LinkGoogle Scholar2. WEISSPARKER SJ: Pyelonephritis: its relation to vascular lesions and to arterial hypertension. Medicine 18: 221, 1939. CrossrefGoogle Scholar3. BELL ET: Renal Diseases, 2d ed., Lea & Febiger, Philadelphia, 1950, p. 307. Google Scholar4. SAPHIRCOHEN ONA: Chronic pyelonephritis lenta and the malignant phase of hypertension. Arch. Intern. Med. (Chicago) 104: 748, 1959. CrossrefMedlineGoogle Scholar5. SMYTHE CM: Renal infection in hypertension; cause or effect, in Hypertension: Recent Advances. Second Hahnemann Symposium on Hypertensive Disease, ed. by Brest, A. N., and Moyer, J. H., Lea & Febiger, Philadelphia, 1961, p. 143. Google Scholar6. CRUZ-COKE R: A genetic study of blood pressure in chronic pyelonephritis. Acta Genet. 11: 58, 1961. MedlineGoogle Scholar7. KIPNISJACKSONDALLENBACHSCHOENBERGER GPGGFDJ: Renal biopsy in pyelonephritis. Arch. Intern. Med. (Chicago) 95: 445, 1955. CrossrefGoogle Scholar8. KIMMELSTIELKIMBERESWELLMAN POJJAK: Chronic pyelonephritis. Amer. J. Med. 30: 589, 1961. CrossrefMedlineGoogle Scholar9. KATZBOURDO YJSR: Chronic pyelonephritis, in Annual Review of Medicine, vol. 13, 1962, ed. by Rytand, D. A., and Creger, W. P., Annual Reviews, Inc., Palo Alto, 1962, p. 481. CrossrefGoogle Scholar10. FREEDMAN LR: Prolonged observations on a group of patients with acute urinary tract infections, in Biology of Pyelonephritis. Henry Ford Hospital International Symposium, ed. by Quinn, E. L., and Kass, E. H., Little, Brown and Company, Boston, 1960, p. 345. Google Scholar11. KASSMIALLSTUART EHWEKL: Relationship of bacteriuria to hypertension: an epidemiological study. J. Clin. Invest. 40: 1053, 1961. Google Scholar12. SWITZER J: Bacteriuria in a healthy population and its relation to hypertension and pyelonephritis. New Eng. J. Med. 264: 7, 1961. CrossrefMedlineGoogle Scholar13. KLEEMANHEWITTGUZE CRWLLB: Pyelonephritis. Medicine 39: 3, 1960. MedlineGoogle Scholar14. KINCAID-SMITH P: Vascular obstruction in chronic pyelonephritic kidneys and its relation to hypertension. Lancet 269: 1263, 1955. CrossrefMedlineGoogle Scholar15. HEPTINSTALLMICHAELSBRUMFITT RHLW: Experimental pyelonephritis: role of arterial narrowing in production of the kidney of chronic pyelonephritis. J. Path. Bact. 80: 249, 1960. CrossrefMedlineGoogle Scholar16. WELCHHARRISDEWEERD HCLEJH: Nephrectomy in juvenile hypertension associated with renal disease: report of 15 cases. Pediatrics 21: 941, 1958. MedlineGoogle Scholar17. GRIEBLEJACKSON HGGG: Bacteriuria, pyelonephritis, and hypertension: a clinical and pathologic study, in Biology of Pyelonephritis, Henry Ford Hospital International Symposium, ed. by Quinn, E. L., and Kass, E. H., Little, Brown and Company, Boston, 1960, pp. 485-508. Google Scholar18. SOMMERSROBBINSRABINKNAACK SCGBDSCT: Chronic pyelonephritis, renal tubular atrophy, and hypertension. Arch. Intern. Med. (Chicago) 110: 505, 1962. CrossrefMedlineGoogle Scholar19. MERRILLGIORDANOHEETDERKS JPCDR: The role of the kidney in human hypertension. I. Failure of hypertension to develop in the renoprival subject. Amer. J. Med. 31: 931, 1961. CrossrefMedlineGoogle Scholar20. BRAUDESHAPIROSIEMIENSKI AIAPJ: Hematogenous pyelonephritis in rats. I. Its pathogenesis when produced by a simple new method. J. Clin. Invest. 34: 1489, 1955. CrossrefMedlineGoogle Scholar21. SHAPIROBRAUDESIEMIENSKI APAIJ: Hematogenous pyelonephritis in rats. II. Production of chronic pyelonephritis by Escherichia coli. Proc. Soc. Exp. Biol. Med. 91: 18, 1956. CrossrefMedlineGoogle Scholar22. BRAUDESHAPIROSIEMIENSKI AIAPJ: Hematogenous pyelonephritis in rats. III. Relationship of bacterial species to the pathogenesis of acute pyelonephritis. J. Bact. 77: 270, 1959. CrossrefMedlineGoogle Scholar23. SHAPIROBRAUDESIEMIENSKI APAIJ: Hematogenous pyelonephritis in rats. IV. Relationship of bacterial species to the pathogenesis and sequelae of chronic pyelonephritis. J. Clin. Invest. 38: 1228, 1959. CrossrefMedlineGoogle Scholar24. SHAPIROKOBERNICK APJL: Effects of unilateral nephrectomy and mixed infection on blood pressure of rats with experimental chronic pyelonephritis. Circ. Res. 7: 936, 1959. CrossrefMedlineGoogle Scholar25. SHAPIRO AP: Susceptibility of rats with DCA hypertension to experimental pyelonephritis and aggravation of DCA hypertension by renal infection. J. Lab. Clin. Med. 55: 715, 1960. MedlineGoogle Scholar26. SHAPIROKOBERNICK APJL: Susceptibility of rats with renal hypertension to pyelonephritis and predisposition of rats with chronic pyelonephritis to hormonal hypertension. Circ. Res. 9: 869, 1961. CrossrefGoogle Scholar27. GUZEKALMANSON LBGM: Pyelonephritis. III. Observations on the association between chronic pyelonephritis and hypertension in the rat. Proc. Soc. Exp. Biol. Med. 108: 496, 1961. CrossrefMedlineGoogle Scholar28. HEPTINSTALLGORRILL RHRH: Experimental pyelonephritis and its effect on blood pressure. J. Path. Bact. 69: 191, 1955. CrossrefMedlineGoogle Scholar29. VIVALDIZANGWILLCOTRANKASS EDPREH: Experimental pyelonephritis consequent to induction of bacteriuria, in Biology of Pyelonephritis, Henry Ford Hospital International Symposium, ed. by Quinn, E. L., and Kass, E. H., Little, Brown and Company, Boston, 1960, p. 27. Google Scholar30. HEPTINSTALL RH: Experimental pyelonephritis. The effect of chronic infection on the blood pressure in the rat. Brit. J. Exp. Path. 43: 333, 1962. MedlineGoogle Scholar31. SPITZNAGELSCHROEDER JKHA: Experimental pyelonephritis and hypertension in rats. Proc. Soc. Exp. Biol. Med. 77: 762, 1951. CrossrefMedlineGoogle Scholar32. PRÂTBENESOVABARTONICEK VMM: Long-term study of blood pressure in rabbits with unilateral chronic pyelonephritis or unilateral hydronephrosis. Physiol. Bohemoslov. 11: 14, 1962. MedlineGoogle Scholar33. GROLLMAN A: Simplified procedure for producing chronic renal hypertension in the mammal. Proc. Soc. Exp. Biol. Med. 57: 102, 1944. CrossrefGoogle Scholar34. SHAPIROMELHADO APJ: Factors affecting the development of hypertensive vascular disease in rats. Proc. Soc. Exp. Biol. Med. 96: 619, 1957. CrossrefMedlineGoogle Scholar35. KOLETSKY S: Necrotizing vascular disease in the rat. II. Role of sodium chloride. Arch. Path. (Chicago) 63: 405, 1957. MedlineGoogle Scholar36. DUSTANMASSON HPGM: Contribution of adrenal cortex to renal and renoprival hypertension. Circulation 17: 765, 1958. CrossrefMedlineGoogle Scholar37. MERRIAMSOMMERSSMITHWICK JCSCRH: Clinicopathologic correlations of renal biopsies in hypertension with pyelonephritis. Circulation 17: 243, 1958. CrossrefMedlineGoogle Scholar38. SCHREINER GE: Comment in discussion, in Biology of Pyelonephritis, Henry Ford Hospital International Symposium, ed. by Quinn, E. L., and Kass, E. H., Little, Brown and Company, Boston, 1960, p. 271. Google Scholar39. SMYTHE CM: Pyelonephritis as a cause of hypertension. Amer. J. Cardiol. 9: 692, 1962. CrossrefMedlineGoogle Scholar40. GOLDBLATT H: Pathogenesis of malignant hypertension. Circulation 16: 697, 1957. CrossrefMedlineGoogle Scholar41. PIERCE EC: Renal lymphatics. Anat. Rec. 90: 315, 1944. CrossrefGoogle Scholar42. ROCHAGUZEFREEDMANBEESON HLBLRPB: Experimental pyelonephritis. III. Influence of localized injury in different parts of the kidney on susceptibility to bacillary infection. Yale J. Biol. Med. 30: 341, 1958. MedlineGoogle Scholar43. BRAUDESIEMIENSKI AIJ: Urease in experimental pyelonephritis. J. Bact. 80: 171, 1960. CrossrefMedlineGoogle Scholar44. BEESONROWLEY PBD: The role of natural inhibitors in the mechanism of localization of bacteria in the kidney, in Biology of Pyelonephritis, Henry Ford Hospital International Symposium, ed. by Quinn, E. L., and Kass, E. H., Little, Brown and Company, Boston, 1960, p. 427. Google Scholar45. WOODS JW: Susceptibility of rats with hormonal hypertension to experimental pyelonephritis. J. Clin. Invest. 37: 1686, 1958. CrossrefMedlineGoogle Scholar46. WOODS JW: Susceptibility to experimental pyelonephritis when humoral hypertension is prevented by hypotensive drugs. J. Clin. Invest. 39: 1813, 1960. CrossrefMedlineGoogle Scholar47. BRACKETTSMYTHE NCCM: Influence of hypertension on susceptibility of rat kidney to infection. J. Lab. Clin. Med. 55: 430, 1960. Google Scholar48. HEPTINSTALLSTRYKER RHM: Experimental pyelonephritis. A study of the susceptibility of the hypertensive kidney to infection in the rat. Bull. Hopkins Hosp. 111: 292, 1962. MedlineGoogle Scholar49. JONESSHAPIRO RKAP: Increased susceptibility to pyelonephritis during acute hypertension by angiotensin II and norepinephrine. J. Clin. Invest. 42: 179, 1963. CrossrefMedlineGoogle Scholar50. BROD J: Chronic pyelonephritis. Lancet 1: 973, 1956. CrossrefGoogle Scholar51. SANFORDHUNTERDONALDSON JPBP: Localization and fate of E. coli in hematogenous pyelonephritis. J. Exp. Med. 116: 285, 1962. CrossrefMedlineGoogle Scholar52. MOUTSOSSTEINSHAPIRO SEHAP: Evaluation of the urinary catalase test in hypertensive vascular disease. J. Lab. Clin. Med. 59: 847, 1962. MedlineGoogle Scholar53. BRENNERGILBERT BMVE: Elevated levels of lactic dehydrogenase, glutamic-oxalacetic transaminase, and catalase in infected urine. Amer. J. Med. Sci. 245: 31, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, PennsylvaniaFrom the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.The research referred to in this report has been supported by grants from the United States Public Health Service, the American Heart Association, and the Health Research and Services Foundation of the United Fund of Allegheny County.Requests for reprints should be addressed to Alvin P. Shapiro, M.D., Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of Vibration, Noise and Restraint on Heart Rate, Blood Pressure and Renal Blood Flow in the PigHarnwegsinfekte und primär abakterielle chronisch-interstitielle NephritidenA SURVEY OF 164 FINNISH CHILDREN AND ADOLESCENTS WITH HYPERTENSIONUrinary tract infection: Value of early diagnosisExperimental pyelonephritisBacterial infection in renal homotransplant recipientsUreteral reflux in pediatric patientsDevelopment of Bacteriuria in a Hypertensive Population A 7-Year Follow-up StudyALVIN P. SHAPIRO, M.D., JOSEPH D. SAPIRA, M.D., EILEEN T. SCHEIB, B.A.Hypertension in renal parenchymal diseaseRenal artery stenosis and hypertensionEXPERIMENTAL PYELONEPHRITISCONN'S SYNDROME COMPLICATED BY FULMINANT PYELONEPHRITIS IN AN OLD PATIENTHypertension, pyelonephritis and renal failureEnvironment and the KidneyA comparison of unilateral pyelonephritis and renal artery stenosis associated with hypertension 1 July 1963Volume 59, Issue 1_Part_1Page: 37-52KeywordsAttentionHealth services researchHeartHypertensionKidneysMedical servicesPyelonephritisVascular diseases Issue Published: 1 July 1963 PDF downloadLoading ...