tbuckley/cabot-search huggingface dataset:
Leukemia in the Elderly
Authors: PETER V. SACKS
Journal: Annals of Internal Medicine (1974)

Comments1 July 1974Leukemia in the ElderlyPETER V. SACKS, M.D., MEHDI TAVASSOLI, M.D., F.A.C.P.PETER V. SACKS, M.D.Search for more papers by this author, MEHDI TAVASSOLI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-133_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The encouraging paper by Dr. Grann and colleagues (1) on the results of treatment of acute granulocytic leukemia has a serious flaw; the failure to mention drug dosages. Although we realize that the data were accumulated retrospectively over a period covering a number of protocols, it would be important to know whether the doses of cytosine arabinoside and thioguanine given to the "elderly" patients, after 1969, equaled those given to the "younger" patients. Is it possible that the excellent remission rates in these elderly patients reflects a "tempered" approach with delivery of significantly less than the projected...Reference1. GRANNERICKSONFLANNERY VRJ: The therapy of acute granulocytic leukemia in patients more than 50 years old. Ann Intern Med 80:15-20, 1974 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Hematology Scripps Clinic and Research Foundation La Jolla, California 92037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1974Volume 81, Issue 1Page: 133-133KeywordsCytosineDrugsElderlyThioguanine Issue Published: 1 July 1974 PDF downloadLoading ...
Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination
Authors: Constandina Pospori, Shao-An Xue, Angelika Holler, Cecile Voisine, Mario Perro, Judith King, Farnaz Fallah-Arani, Barry Flutter, Ronjon Chakraverty, Hans J. Stauss, Emma C. Morris
Journal: Blood (2011)
Rating Physician Performance: Peers or Patients?
Authors: Joel D. Howell
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Dr Ramsey and his colleagues<sup>1</sup>are to be congratulated on an elegant study of peer ratings of physicians' humanistic qualities and communications skills, and Dr Petersdorf<sup>2</sup>nicely outlines potential problems that could arise if we try systematically to implement a professional associates rating questionnaire. But before implementing such methods, we need to establish that they can answer the relevant questions. The questionnaires measured very well what physicians thought about other physicians, and compared those findings with what nurses thought about those physicians. But for communications and humanistic skills, the important issue is what patients think about their physicians. Certainly, it is far easier to rely on peer assessment than patient assessment. This may be appropriate for measuring some characteristics of how physicians interact with their patients. In terms of technical abilities, physicians may be able to judge their peers quite well. But their ability is
Abstract 1697: Gene signature, histopathological classification, and cisplatin-activated expression profiles in human epithelial ovarian cancer
Authors: Yi Guo, Honglan Zhu, Xiaobing Liang, Michael D. Mueller, Jing Jie Yu
Journal: Cancer Research (2011)

Abstract PURPOSES: To identify biomarkers in epithelial ovarian cancer (EOC) and investigate mechanism of cisplatin-induced activation and expression, 50 genes were screened from 131 ovarian cancer patient samples. Twenty expressed genes were assessed in 30 samples by qPCR. Ovarian cancer cells were treated with cisplatin and studied for expression of cisplatin-activated genes. RESULTS: Studies of gene signature of histopathological classification TAL2, EGF, ILF3 and UBE21 shown unique expression patterns in EOC histological types. The expression of ILF3 in tumor tissues was significantly higher than normal samples, and especially high in serous carcinomas, compared to mucinous, endometrial and clear cell carcinomas. ILF3 and UBE21 showed overexpression in advanced stage and poorly differentiated patient samples. Investigation of cisplatin-activated signaling indicated increased mRNA expression of ILF3, UBE21 and other kinases involved in cell cycle checkpoint, DNA repair, and apoptosis such as p53, Chk2, c-jun, and hMLH1. CONCLUSIONS: Overexpression of ILF3 and UBE21 in advanced stage and advanced grade of EOC specimens suggests that these two genes may play important roles in tumorgenesis, tumor progression and pathological differentiation of the disease. Results from in vitro studies demonstrate that activated genes p53, Chk2, c-jun and hMLH1 play a role in chemo-resistance to cisplatin therapy. Further investigation of the molecular mechanisms of the identified genes is warranted. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1697. doi:10.1158/1538-7445.AM2011-1697
Renin release by rat kidney slices incubated in vitro. Role of sodium and of alpha- and beta-adrenergic receptors, and effect of vincristine.
Authors: A M Capponi, M B Vallotton
Journal: Circulation Research (1976)

The role of sodium concentration, of alpha- and beta-adrenergic receptors, and of a microtubular inhibtor (vincristine) on renin release was studied in rat kidney slices in vitro. Renin release was an active, linear, and temperature-dependent process. Kidneys from young rats released much more renin than those from adults. Lowering sodium concentration inhibited renin release by one-half, even when osmolality was kept constant. Isoproterenol (10(-8) to 10(-5) M) stimulated renin release significantly in a partially dose-related manner. dl-propranolol inhibited this stimulation. Significant (P less than 0.05) inhibition of renin release was induced by l-epinephrine or l-norepinephrine (10(-5) M). In the presence of an alpha-receptor blocking drug, phenoxybenzamine (10(-5) M), inhibition no longer occurred with epinephrine and stimulation was observed with l-norepinephrine. Vincristine (10(-5) M) did not affect renin release when slices from the kidneys of normal rats or adrenalectomized, sodium-depleted rats were incubated, but significantly inhibited (P less than 0.01) release that had been stimulated in vitro by isoproterenol. These results suggest to us that there may be (1) a direct or indirect (mediated through the macula densa) effect of sodium on juxtaglomerular cells, (2) an inhibitory role for alpha-adrenergic receptors on renin release, in addition to the stimulatory role of beta-receptors, (3) possible participation of microtubules in isoproterenol-stimulated renin release, and (4) an alternative mode of secretion of renin under stimulation by adrenalectomy and salt depletion.
Benign glandular schwannoma
Authors: Y-C. Kim, H-J. Park, Y-W. Cinn, D.P. Vandersteen
Journal: British Journal of Dermatology (2001)

Journal Article Benign glandular schwannoma Get access Y‐C. Kim, Y‐C. Kim Department of Dermatology, Dankook University College of Medicine, 16‐5 Anseo‐dong, Cheonan, Chungcheong Nam Do 330‐714, Korea *Department of Pathology, St Mary's/Duluth Clinic Health System, 407 East Third Street, Duluth, MN 55805, U.S.A. Y‐C.Kim. E‐mail: kyccc@anseo.dankook.ac.kr Search for other works by this author on: Oxford Academic Google Scholar H‐J. Park, H‐J. Park Department of Dermatology, Dankook University College of Medicine, 16‐5 Anseo‐dong, Cheonan, Chungcheong Nam Do 330‐714, Korea *Department of Pathology, St Mary's/Duluth Clinic Health System, 407 East Third Street, Duluth, MN 55805, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar Y‐W. Cinn, Y‐W. Cinn Department of Dermatology, Dankook University College of Medicine, 16‐5 Anseo‐dong, Cheonan, Chungcheong Nam Do 330‐714, Korea *Department of Pathology, St Mary's/Duluth Clinic Health System, 407 East Third Street, Duluth, MN 55805, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar D.P. Vandersteen D.P. Vandersteen Department of Dermatology, Dankook University College of Medicine, 16‐5 Anseo‐dong, Cheonan, Chungcheong Nam Do 330‐714, Korea *Department of Pathology, St Mary's/Duluth Clinic Health System, 407 East Third Street, Duluth, MN 55805, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 5, 1 November 2001, Pages 834–837, https://doi.org/10.1046/j.1365-2133.2001.04476.x Published: 01 November 2001
"PROTECTIVE DEVICE IN NOSE AND THROAT WORK"
Authors: C. D. Van Wagenen
Journal: JAMA (1925)

<h3>To the Editor:</h3> —A short article with illustration, entitled "Protective Device in Nose and Throat Work," by Dr. W. N. Lipscomb of Lexington, Ky., appeared inThe Journal, April 11, 1925. About fifteen years ago the surgical supply houses were carrying glass shields for just such work as is now under discussion. The catalogue price seemed excessive to me, as I desired to install such a device in my service as attending otolaryngologist to Seton Hospital, this city, whose 500 beds were devoted to the care of the tuberculous poor exclusively, and some other means toward the end desired was sought. Two 4 foot lengths of gas pipe were assembled, of such bore that one would telescope into the other. The hospital carpenter was instructed to fix the larger piece of piping to a weighted box mounted on small wheels. The smaller piece of piping was bent to a right
Management of Diabetes Mellitus: A Guide to the Pattern Approach
Authors: Richard J. Barth
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survey of viral warts, herpes zoster and herpes simplex in patients with secondary immune deficiencies and neoplasms
Authors: Warwick L. Morison
Journal: British Journal of Dermatology (1974)

Journal Article Survey of viral warts, herpes zoster and herpes simplex in patients with secondary immune deficiencies and neoplasms Get access Warwick L. Morison Warwick L. Morison St Helier Hospital. Carshalton Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Pages 18–19, https://doi.org/10.1111/j.1365-2133.1974.tb12480.x Published: 01 July 1974
Allergy to bumblebee venom. III. Immunotherapy follow‐up study (safety and efficacy) in patients with occupational bumblebee‐venom anaphylaxis
Authors: N.W. De Jong, H. De Groot, A.M. Vermeulen
Journal: Allergy (1999)

The objective was to investigate whether venom immunotherapy with bumblebee venom (BBV) is safe and effective.Eleven patients with severe occupational anaphylaxis caused by stings of bumblebees were studied. Sensitization to bumblebee venom was confirmed by skin tests and RAST. Immunotherapy was started with bumblebee venom extract by the semirush procedure, because these patients showed a primary sensitization to Bombus venom, and a low or absent degree of cross-reactivity with honeybee venom. IgE titer and skin tests with bumblebee venom were performed yearly. Efficacy was evaluated by means of in-hospital sting challenge and/or occupational field stings from bumblebees.All patients reached maintenance dose in 6 weeks without severe side-effects. During the follow-up period (1.5-5 years), three systemic reactions in two patients were seen in 20 bumblebee stings. However, these reactions were milder than the index sting.Immunotherapy with bumblebee venom is safe and effective, and is comparable with honeybee and yellow-jacket venom immunotherapy.
Cryoprecipitate Concentrates of Factor VIII for Surgery in Hemophiliacs
Authors: JEREMY V. COOKE
Journal: Annals of Internal Medicine (1968)

Pool's original method of preparing cryoprecipitate for treating hemophilia was found to be suitable for preparing factor VIII from acidified plasma that is a by-product of platelet concentrates. Preparation of cryoprecipitate was simplified by using residual ice crystals as a collecting filter to eliminate centrifugation and as a suspending medium to eliminate exogenous diluent. Experience with four hemophiliacs undergoing seven surgical procedures is described. Satisfactory factor VIII levels were easily maintained with cryoprecipitate in all patients, and no complications were associated with its use. Recovery of factor VIII in vitro and in vivo is evaluated, and therapeutic regimens that allow for variations in yield to assure hemostasis without laboratory control are outlined. Cryoprecipitate is superior to plasma and as effective as commercially available factor VIII concentrates but cheaper.
Bronchogenic vs Metastatic Carcinoma of the Lung
Authors: John D. Steele
Journal: JAMA (1966)

To the Editor:—  In his letter ( 196 : 459, 1966), Dr. Milton B. Rosenblatt implies that solitary metastatic tumors of the lung are commonly mistaken for bronchogenic carcinomas even after resected tissue has been examined microscopically.  Our evidence does not support this supposition. In a series of 306 malignant tumors of the lung appearing as solitary pulmonary nodules 6 cm and less in diameter, only 26 were metastatic. In 23 of the 26 there was a history of previous malignancy outside the lung ( J Thorac Cardiov Surg  46 :21, 1963).  Our patients have been followed for from 2 1/2 to 6 years, less than 2% having possibly been lost to follow-up. The relative five-year survival rate of the patients having bronchogenic carcinoma is 38.6% ( Ann Thorac Surg  2 :368, 1966). In many cases, autopsies were performed.  In no instance has any tumor originally classified as a primary bronchogenic carcinoma later proved to
Analyses of volatile organic compounds from human skin
Authors: M. Gallagher, C.J. Wysocki, J.J. Leyden, A.I. Spielman, X. Sun, G. Preti
Journal: British Journal of Dermatology (2008)

Journal Article Analyses of volatile organic compounds from human skin Get access M. Gallagher, M. Gallagher Monell Chemical Senses Center, Philadelphia, PA 19104, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar C.J. Wysocki, C.J. Wysocki Monell Chemical Senses Center, Philadelphia, PA 19104, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J.J. Leyden, J.J. Leyden Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar A.I. Spielman, A.I. Spielman College of Dentistry, New York University, New York, NY 10010, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar X. Sun, X. Sun College of Dentistry, New York University, New York, NY 10010, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar G. Preti G. Preti Monell Chemical Senses Center, Philadelphia, PA 19104, U.S.A.Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A. Correspondence: George Preti. E‐mail: preti@monell.org Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 4, 1 October 2008, Pages 780–791, https://doi.org/10.1111/j.1365-2133.2008.08748.x Published: 01 October 2008
The National Emphysema Treatment Trial — How Strong Is the Evidence?
Authors: James H. Ware
Journal: New England Journal of Medicine (2003)

The National Emphysema Treatment Trial (NETT), reported in this issue of the Journal (pages 2059–2073) raises interesting questions about the interpretation of secondary analyses of data collected in clinical trials. After exclusion of 140 patients with a high risk of death from surgery according to an interim analysis,1 the 538 patients who were randomly assigned to surgery were more likely than the 540 assigned to medical therapy to have improvements in exercise capacity and quality of life, but there was no reduction in mortality during an average of 29 months of follow-up.In the secondary analyses, however, the effects of . . .
General Practitioners’ Approach to Hypertension in Urban Pakistan
Authors: Tazeen H. Jafar, Saleem Jessani, Fahim H. Jafary, Mohammad Ishaq, Raza Orkazai, Sarwar Orkazai, Andrew S. Levey, Nish Chaturvedi
Journal: Circulation (2005)

Background— Control of blood pressure (BP) remains suboptimal worldwide. The objective of this study was to determine whether (primary) general practitioners’ (GPs) approach to high BP is in accordance with international guidelines. Methods and Results— We conducted a cross-sectional survey of 1000 randomly selected GPs from urban areas in Pakistan during 2002. A rigorously developed questionnaire on (1) type of practice and (2) detection, (3) evaluation, (4) treatment, and (5) source of information about high BP was administered by trained medical personnel. A total of 1051 GPs were approached, and 1000 (95%) consented to enroll; 766 were male and 655 had been in practice ≥10 years. The average number of patients (SD) seen per day was 48.2 (42.7). Overall, 30.6% (29.0% to 32.3%) and 79.7% (78.3% to 81.0%) of GPs used incorrect BP cutoffs to diagnose hypertension in patients &lt;60 and ≥60 years, respectively. Appropriate therapy for hypertension in the elderly was initiated by only 34.7% (33.0% to 36.3%) of GPs. The use of sedatives either alone (23.8%) or in combination with antihypertensive agents as first-line medication for lowering BP was reported by 45.0% (43.2% to 46.7%). Thiazide diuretics were rarely prescribed (4.2%). Sublingual antihypertensive agents were prescribed by 68.7% (67.1% to 70.3%) of GPs for treating very high levels of BP. The practices of recent graduates from medical school were not better than those of older graduates. Conclusions— GPs in Pakistan underdiagnose and undertreat high BP, especially in the elderly. Our findings underscore the need for urgent revision of teaching curricula in medical schools with regard to the risks, complications, and management of hypertension, as well as the initiation of widespread and intensive continuing medical education for all physicians involved in the management of patients with hypertension. Particular efforts are needed to encourage the use of low-cost thiazide diuretics as antihypertensive agents in developing countries.
TUMORS OF THE BLADDER.Read by Invitation before the Wisconsin State Medical Society, May 5, 1893.
Authors: JOHN B. HAMILTON
Journal: JAMA (1893)

The literature of the subject of tumors of the bladder is almost wholly modern. The ancients had a lively sense of the dangers of meddlesome interference with the bladder and although the operation of stone crushing has probably been known from the earliest times it is only since the day of Civiale and Leroy d'Etiolles that tumors of the bladder began to be commonly extirpated. According to Tuffier, Varner in 1750 removed a vesical polypus, but no details of the case are given. The silence on the subject is the more remarkable when we consider that instead of being infrequent among other affections of the bladder tumors are common. Sir Henry Thompson, than whom there has been no higher modern authority, relates that in November, 1880, he practiced exploratory incision in the urethra for a case which he was unable to diagnose by the methods then adopted; "most unexpectedly," he
Triamterene-Induced Nephrolithiasis
Authors: Robert W. Grunberg
Journal: JAMA (1981)

<h3>To the Editor.—</h3> We wish to report a case of triamterene-induced nephrolithiasis. Other cases have been published elsewhere.<sup>1,2</sup> <h3>Report of a Case.—</h3> A 44-year-old man was admitted with left ureteral colic. The family history was negative for kidney stone disease. Since June 1974, he had been receiving insulin for adult-onset diabetes. He was also hypertensive for the past six years, and his condition has been controlled with clonidine hydrochloride (Catapres), 0.2 mg daily, hydrochlorothiazide, 50 mg daily, and triamterene, 200 mg daily. An intravenous pyelogram done on admission showed a 3-mm calcification at the left ureterovesical junction with obstruction. An attempt to remove the impacted stone via cystoscopy under spinal anesthesia was unsuccessful. The next day the stone was passed spontaneously. The patient had normal serum levels of calcium, phosphorus, uric acid, and electrolytes. Twenty-four-hour excretion of calcium and oxalate was normal, but the 24-hour urine for uric acid
Treating Gulf War Veterans' Illnesses—Are More Focused Studies Needed?
Authors: Matthew Hotopf
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal