tbuckley/cabot-search huggingface dataset:
Health budgets would benefit from ambitious climate change goals
Authors: R. Watson
Journal: BMJ (2010)

An ambitious climate change policy would bring European Union governments major public health and financial benefits, says new research published on 14 September.

By aiming to reduce greenhouse gas emissions by 30%, the 27 member EU would make annual health savings of up to €30.5bn (₤25.3bn; $38.8bn) by 2020 in addition to the €52bn health gains that are expected from the existing 20% reduction target.

The forecasts come as European environment ministers prepare to finalise the EU’s negotiating position in mid-October for the next stage of the global …
Antidepressants in elderly people
Authors: I. B. Hickie
Journal: BMJ (2011)

<h3>Abstract</h3> It has been reported recently that DNA 5-methylcytosine (5mC) in CpG contexts can be detected using PacBio circular consensus sequencing (CCS). However, the accuracy and robustness of computational methods using long CCS reads still need to be improved. In this study, we present a deep learning method, ccsmeth, to detect DNA 5mCpGs from PacBio CCS subreads. ccsmeth utilizes attention-based bidirectional Gated Recurrent Unit (GRU) networks to infer DNA methylation states. Testing ccsmeth using CCS subreads of amplified DNA and M.SssI-treated DNA, we found that ccsmeth achieved higher performances than existing methods. We also compared the results of ccsmeth on long CCS reads with bisulfite sequencing and Nanopore sequencing. The results demonstrated that ccsmeth can accurately detect 5mCpGs from CCS data sequenced using &gt;10 kb insert library. Moreover, using PacBio CCS data, we proposed a pipeline which can detect haplotype-aware methylation in human.
Pyometra after Pelvic Floor Repair
Authors: R. Hodkinson
Journal: BMJ (1950)

MEDICAL MEMORANDAIJONu 469of the urethra: the last possibility was unlikely because of the freedom from urinary disturbance.Operation.-Onehour later the child was taken to the theatre and anaesthetized and a further examination was carried out.The swelling had increased in size, and purple-black areas, in addition to a large blister, were present on its surface.It com- prised the prepuce and glans clitoris, which were much engorged and presented as two distended shiny prominences.At the base of the swelling one could feel a firm constriction, so beneath this a probe introducer was placed and the constriction divided.A fine thread about 1 in. in length, with closely cut knot at one end, was found to be the cause of the strangulation.The urethra, vagina, and rest of the vulva were normal.The following morning the swelling was less congested, and 10 days later the clitoris had assumed its normal appearance.I was very puzzled to know how the thread came to be round the clitoris.After a short conversation with the child she admitted that she had twisted a piece of cotton round the skin in front, but gave no reason for doing so.It is interesting to note that for homework she had to write an essay on " life in hospital."We may assume that her brief visit to the Radcliffe Infirmary would add con- siderable local co!our to this literary effort.
Less than half of essential drugs for children are available in most central African countries
Authors: R. Dobson
Journal: BMJ (2009)

The availability of essential drugs for children in central Africa is poor, a new study shows. In only three of 14 countries surveyed were more than 50% of the drugs that are considered essential—as indicated by national lists and standard treatment guidelines—available from central medical stores.

“If the availability of these essential medicines for children is as poor as is suggested by the results of this study, we have a lot to do to understand what is happening in the supply systems for medicines in these countries before we can improve them,” say the …
Effect of general practitioners' advice against smoking
Authors: M A H Russell, C Wilson, C Taylor, C D Baker
Journal: BMJ (1979)

During four weeks all 2138 cigarette smokers attending the surgeries of 28 general practitioners (GPs) in five group practices in London were allocated to one of four groups: group 1 comprised non-intervention controls; group 2 comprised questionnaire-only controls; group 3 were advised by their GP to stop smoking; and group 4 were advised to stop smoking, given a leaflet to help them, and warned that they would be followed-up. Adequate data for follow-up were obtained from 1884 patients (88%) at one month and 1567 (73%) at one year. Changes in motivation and intention to stop smoking were evident immediately after advice was given. Of the people who stopped smoking, most did so because of the advice. This was achieved by motivating more people to try to stop smoking rather than increasing the success rate among those who did try. The effect was strongest during the first month but still evident over the next three months and was enhanced by the leaflet and warning about follow-up. An additional effect over the longer term was a lower relapse rate among those who stopped, but this was not enhanced by the leaflet and warning about follow-up. The proportions who stopped smoking during the first month and were still not smoking one year later were 0.3%, 1.6%, 3.3%, and 5.1% in the four groups respectively (P <0.001).The results suggest that any GP who adopts this simple routine could expect about 25 long-term successes yearly. If all GPs in the UK participated the yield would exceed half a million ex-smokers a year. This target could not be matched by increasing the present 50 or so special withdrawal clinics to 10 000.
REDUCING THE COST OF TAVR: AN EVALUATION OF THE IMPACT OF PERMANENT PACEMAKER RATE ON THE COST OF TRANSCATHETER AORTIC VALVE REPLACEMENT FROM THE HOSPITAL PERSPECTIVE
Authors: Brian J. Potter, Christopher Meduri, Philippe Genereux, Ruben L.J. Osnabrugge, Vivek Rajagopal, Andrew Rassi, David Wood, A. Kappetein, David Cohen
Journal: Journal of the American College of Cardiology (2014)
Pregnancy-Associated Hyperkeratosis of the Nipple
Authors: H. William Higgins, Jennifer Jenkins, Thomas D. Horn, George Kroumpouzos
Journal: JAMA Dermatology (2013)

Reported physiologic nipple changes in pregnancy do not include hyperkeratosis and are expected to resolve or improve post partum. Hyperkeratosis of the nipple and/or areola can develop in the context of inflammatory diseases (such as atopic dermatitis), in acanthosis nigricans, as an extension of epidermal nevus, after estrogen treatment, and/or in nevoid hyperkeratosis of the nipple and areola. We performed a clinicopathologic analysis of cases of pregnancy-associated nipple hyperkeratosis.Twenty-five cases of pregnancy-associated nipple hyperkeratosis identified during a 5-year period (January 1, 2007, through December 31, 2012) are reported. The lesions were bilateral and involved predominantly the top of the nipple. Lesions were symptomatic in 17 patients (68%), causing tenderness or discomfort, pruritus, sensitivity to touch, and/or discomfort with breastfeeding. Nine patients (36%) experienced symptomatic aggravation only during pregnancy or breastfeeding. The lesions persisted post partum in 22 patients (88%). Histopathologic features were conspicuous orthokeratotic hyperkeratosis, with papillomatosis and acanthosis being mild or absent.Pregnancy-associated hyperkeratosis of the nipple can be symptomatic and persist post partum. It may represent a physiologic change of pregnancy. The characteristic clinicopathologic features of this disorder allow differentiation from nevoid hyperkeratosis of the nipple and areola. We suggest that this distinctive clinicopathologic entity be called pregnancy-associated hyperkeratosis of the nipple.
(51) Linear norphoea with muscle involvement
Authors: H.J. Dodd, I. Sarkany
Journal: British Journal of Dermatology (1985)

Journal Article (51) Linear norphoea with muscle involvement Get access H.J. Dodd, H.J. Dodd Royal Free Hospital, London NW3 Search for other works by this author on: Oxford Academic Google Scholar I. Sarkany I. Sarkany Royal Free Hospital, London NW3 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 97–98, https://doi.org/10.1111/j.1365-2133.1985.tb13066.x Published: 01 July 1985
Prevention of coronary heart disease
Authors: Andrea Messori, Benedetta Santarlasci
Journal: BMJ (2004)

Editor—The cost effectiveness study published by Marshall is difficult to understand in its technical details not only by average readers but also people with some skill in pharmacoeconomics.1

We think that the part of this study that presents the data of the average cost effectiveness (table 1 of the article) is useless because the practical implications of this study, along with the assessment of the pharmacoeconomic profile of the various drugs, rely exclusively on the findings of the incremental cost effectiveness analysis (the data presented in table 2).

Table 2 is not adequately explained by the author. For this reason, we propose a more detailed layout, in which much more information is presented and the labelling of each row is made more explicit (see bmj.com).
Dronedarone for Atrial Fibrillation — An Odyssey
Authors: Peter J. Zimetbaum
Journal: New England Journal of Medicine (2009)

On March 18, 2009, the Cardiovascular and Renal Drugs Advisory Committee of the Food and Drug Administration (FDA) convened to determine whether the antiarrhythmic drug dronedarone should be approved for the reduction of cardiovascular morbidity and mortality among patients with atrial fibrillation or atrial flutter. It has been 10 years since the FDA approved dofetilide, the last antiarrhythmic drug for suppression of atrial fibrillation to reach the U.S. market. Because of an increased risk of torsades de pointes, particularly at the initiation of therapy, dofetilide's label includes a requirement that therapy be initiated in the hospital and monitored by a . . .
New York hospitals are to be paid to train fewer doctors
Authors: D. Josefson
Journal: BMJ (1997)

Teaching hospitals in New York State are to be paid to reduce their numbers of graduate medical training positions.

The Graduate Medical Education Demonstration Project will provide $400m (£250m) in payments over six years to New York hospitals that agree to reduce their training programmes by 20-25%. The project is an attempt to stem the surplus of doctors nationwide and to reduce the relative excess of specialists.



New York has an oversupply of doctors

HANK MORGAN/SPL



New York state has been chosen to pilot the …
Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells
Authors: Su Mi Choi, Hua Liu, Pooja Chaudhari, Yonghak Kim, Linzhao Cheng, Jian Feng, Saul Sharkis, Zhaohui Ye, Yoon-Young Jang
Journal: Blood (2011)
TRANSCATHETER AORTIC VALVE IMPLANTATION UNDER CONSCIOUS SEDATION VERSUS GENERAL ANESTHESIA WITH INTUBATION
Authors: Itsik Ben-Dor, Ron Waksman, Lowell F. Satler, Yanlin Li, Asmir I. Syed, Sara D. Collins, Gabriel Maluenda, Manuel A. Gonzalez, Kohei Wakabayashi, Cedric Delhaye, Michael A. Gaglia, Petros Okubagzi, Rebecca Torguson, Zhenyi Xue, William O. Suddath, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard
Journal: Journal of the American College of Cardiology (2010)
Response to Comment on: Beverly et al. Do Older Adults Aged 60–75 Years Benefit From Diabetes Behavioral Interventions? Diabetes Care 2013;36:1501–1506
Authors: Elizabeth A. Beverly, Katie Weinger
Journal: Diabetes Care (2013)

We thank Trento et al. (1) for their interest in our recent article on the benefit of diabetes behavioral interventions for improving A1C in long-duration, poorly controlled older diabetic patients. Our article describes a secondary analysis of data from a three-arm, parallel-designed randomized controlled trial that tested the efficacy of a highly structured behavioral diabetes intervention via comparisons with standard group education and individual education (2). Thus, the original aim of the study was not to assess age differences in group versus individual education. Also, the study did not recruit adults aged 76 years and above, so the findings may not be representative for adults aged 76 years and …
Preexisting Lymphatic Endothelium but not Endothelial Progenitor Cells Are Essential for Tumor Lymphangiogenesis and Lymphatic Metastasis
Authors: Yulong He, Iiro Rajantie, Maritta Ilmonen, Taija Makinen, Marika J. Karkkainen, Paula Haiko, Petri Salven, Kari Alitalo
Journal: Cancer Research (2004)

Abstract Endothelial progenitor cells have been shown to contribute to angiogenesis in various tumor models. Here, we have studied the relative contributions of bone marrow (BM)-derived endothelial progenitors and pre-existing lymphatic vessels to tumor lymphangiogenesis. We did not find significant incorporation of genetically marked BM-derived cells in lymphatic vessels during tumor- or vascular endothelial growth factor C-induced lymphangiogenesis. The degree of tumor lymphangiogenesis correlated with lymphatic vessel density in the peritumoral area, and despite tumor lymphangiogenesis, lymphatic metastasis failed to occur in gene-targeted vascular endothelial growth factor C+/− mice that have hypoplasia of the lymphatic network. Our data demonstrate that during tumor lymphangiogenesis and cancer cell dissemination via the lymphatics, the newly formed lymphatic vessels sprout from the pre-existing local lymphatic network with little if any incorporation of BM-derived endothelial progenitor cells.
Therapeutic Hypothermia After Cardiac Arrest Without Return of Consciousness
Authors: Neal E. Little, Eva L. Feldman
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Platelet-induced vascular smooth muscle cell proliferation is modulated by the growth amplification factors serotonin and adenosine diphosphate.
Authors: S T Crowley, E C Dempsey, K B Horwitz, L D Horwitz
Journal: Circulation (1994)

BACKGROUND Platelet-mediated mechanisms have been implicated in intimal lesion formation following vascular injury. Although the participation of peptide growth factors has been suspected in this process, little has been known about the possible mitogenic role of other platelet factors that are released at sites of vascular injury. METHODS AND RESULTS We tested the hypothesis that platelet products, which are not peptide growth factors, are important modulators of the platelet-induced smooth muscle cell (SMC) proliferative response by acting as growth amplification factors. In these studies, cell proliferation was assessed by [3H]thymidine incorporation, flow cytometry, and direct cell counting. We examined the potential mitogenicity of several platelet products, including serotonin, ADP, norepinephrine, histamine, platelet-activating factor, the thromboxane A2 mimetic U46619, and bradykinin. Of the platelet products tested, serotonin and ADP induced a synergistic response with peptide growth factors. This synergy was greatest at low growth-factor concentrations. Addition of nonaggregated platelets to quiescent SMC cultures strongly stimulated cell proliferation. Since the addition of suramin to platelet-treated cultures markedly inhibited SMC proliferation, peptide growth factors are most likely the primary mitogens mediating this response. However, platelet-induced proliferation was also markedly reduced by the serotonin antagonists ketanserin and LY53857 (44%), and by the ADP antagonist apyrase (35%). CONCLUSIONS Therefore, serotonin and ADP contribute significantly, in synergy with peptide growth factors, to the platelet-induced SMC proliferative response. We propose that in vivo serotonin and ADP act as amplification factors for SMC proliferation at sites of vascular injury.
1170 PREDICTORS OF DAYS UNABLE TO WORK AMONG GENOTYPE 1 TREATMENT-NAIVE CHRONIC HEPATITIS C PATIENTS: POST-HOC ANALYSES OF DATA FROM PHASE 3 ADVANCE AND ILLUMINATE STUDIES
Authors: N. Hernandez, M. Vera-Llonch, J. Aggarwal, M. Donepudi, Z. Younossi, T.F. Goss
Journal: Journal of Hepatology (2012)
Australian doctors' leader attacks plan to charge to see a GP
Authors: D. Brill
Journal: BMJ (2014)

Australians would have to pay $A7 (£3.8; €4.7; $US6.5) to see their GP under a controversial new scheme that would spell the end of universal free access to primary care.

Announced in May’s federal budget, the copayment would apply to all GP consultations and out of hospital imaging and pathology services from 1 July 2015, if passed by parliament.

The plan includes a massive boost to Australia’s investment in medical research, with $A5 of every $A7 copayment going into a multibillion dollar research “Future Fund.”

General practices would pocket the remaining $A2, but there would be an accompanying $A5 cut in Medicare …
A Case of Possible Pacemaker Undersensing
Authors: Zaid Aziz, Peter Mikolajczak, Paul J. Hauptman
Journal: JAMA Internal Medicine (2015)

Aman inhis90swith a history of hypertension, hypercholesterolemia, sinus node dysfunction, and prior dual-chamber pacemaker implantation presented with 1 month of abdominal pain radiating to his back. The initial chest radiograph demonstrated a dualchamberpermanentpacemakerwith anatrial lead in the right atrial appendage and ventricular lead at the right ventricular (RV) apex. A computed tomography angiogram demonstrated a 5.3 × 5.3-cm infrarenal abdominal aortic aneurysm with thrombus. The patient was urgently taken to the operating room for percutaneous endovascular aneurysm repair. Preoperatively,anelectrocardiogram(ECG)demonstratedatrialventricular (AV) pacing with atrial capture and ventricular pacing “spikes” (or stimuli) just after the onset of a narrow QRS complex (Figure 1). A postoperative ECG (Figure 2) obtained in the postanesthesia care unit did not demonstrate evidence of atrial or ventricular pacing. The fact that the paced narrow QRS complex in Figure 1 is identical to the patient’s nonpaced baseline QRS complex in Figure 2 raises concern (in Figure 1) that the pacemaker was undersensing the intrinsic QRS complex. Question: Did the RV lead undersense (fail to recognize) the patient’s intrinsic QRS complex?
THE EFFECTS OF THE INHALATION OF THE FUMES OF NITRIC ACID.WITH REPORT OF CASES.
Authors: J. N. HALL
Journal: JAMA (1905)

The Denver Fire Department was called to the office of the<i>Denver</i>Post Sept. 20, 1904, at 4 p. m. On arrival they were informed that a carboy of nitric acid had been accidentally broken in an attempt to remove the stopper with a hammer. The acid spread across the floor, coming in contact with the zinc used in etching. Sawdust was used to absorb it, and, rapidly oxidizing, burst into flame here and there, resulting in the call for the firemen. Mr. Bradt, foreman of the department, who was at work in the room, states that the fumes and smoke were not especially irritating until the portable apparatus began playing on the fire, the usual carbonic acid-producing solutions being employed. We find by examination that the acid used contained no appreciable amount of nitrous acid and was of about 38 per cent. strength. About ten gallons of it escaped
Severe Aortic Stenosis With Low Transvalvular Gradient and Severe Left Ventricular Dysfunction
Authors: Heidi M. Connolly, Jae K. Oh, Hartzell V. Schaff, Veronique L. Roger, Sara L. Osborn, David O. Hodge, A. Jamil Tajik
Journal: Circulation (2000)

The outcome of aortic valve replacement in patients with severe aortic stenosis, low transvalvular gradient, and severe left ventricular dysfunction is not well known.Between 1985 and 1995, 52 patients with left ventricular ejection fraction (EF) < or =35% and aortic stenosis with transvalvular mean gradient <30 mm Hg underwent aortic valve replacement. The mean (+/-SD) preoperative characteristics included EF, 26+/-8%; aortic valve mean gradient, 23+/-4 mm Hg; aortic valve area, 0.7+/-0.2 cm(2); and cardiac output, 3.7+/-1.2 L/min. Simultaneous coronary artery bypass graft surgery was performed in 32 patients (62%). Perioperative (30-day) mortality was 21% (11 of 52 patients). Ten additional patients died during follow-up. Advanced age (P=0.048) and small aortic prosthesis size (P=0.03) were significant predictors of hospital mortality by univariate analysis. By multivariate analysis, the only predictor of surgical mortality was smaller prosthesis size. The only predictor of postoperative survival was improvement in postoperative functional class (P=0.04). Postoperative functional improvement occurred in most patients. Postoperative EF was assessed in 93% of survivors; 74% demonstrated improvement. Positive change in EF was related to smaller preoperative aortic valve area and female sex.Despite severe left ventricular dysfunction, low transvalvular mean gradient, and increased operative mortality, aortic valve replacement was associated with improved functional status. Postoperative survival was related to younger patient age and larger aortic prosthesis size, and medium-term survival was related to improved postoperative functional class.
Selective noncompetitive assimilation of bovine testicular beta-galactosidase and bovine liver beta-glucuronidase by generalized gangliosidosis fibroblasts.
Authors: V Hieber, J Distler, R Myerowitz, R D Schmickel, G W Jourdian
Journal: Journal of Clinical Investigation (1980)

Bovine liver beta-glucuronidase and testicular beta-galactosidase were assimilated by generalized gangliosidosis fibroblasts at respectively rates of 90 and 464 times the rate of assimilation of horseradish peroxidase. Assimilation of either of the two enzymes by the fibroblasts was saturable, suggesting the participation of receptor-mediated adsorptive endocytosis for internalization. The rate of assimilation of either enzyme was not affected by high levels of the other enzyme, suggesting that distinct receptors for each enzyme occur on the fibroblasts' cell surface. Furthermore, although assimilation of beta-galactosidase was inhibited by mannose, methyl mannosides, mannosyl alpha 1 leads to 2 mannose, and mannose-6-phosphate, these compounds did not detectably inhibit the assimilation of beta-glucuronidase. These results suggest that testicular beta-galactosidase was assimilated by the well-established phosphomannosyl recognition system. However, liver beta-glucuronidase was assimilated by a distinct, noncompeting, and as yet undefined, recognition system.
Malignant Struma Ovarii With Peritoneal Implants and Pelvic Structures and Liver Metastases Demonstrated by I-131 SPECT and Low-Dose CT
Authors: Shiou-Chi Cherng, Yuh-Feng Wang, Yu-Ming Fan, Ching-Yuan Chen, Yao-Nan Yuan, Cheng-Yi Cheng
Journal: Clinical Nuclear Medicine (2005)

Malignant struma ovarii is a rare disease in gynecology and the optimal treatment regimen for the tumor remains obscure. We present a patient who had malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases shown on posttreatment iodine I-131 single-photon emission tomography (SPECT) and low-dose computed tomography (CT). The roles of I-131 ablation in the management of the disease are reviewed and discussed.