tbuckley/cabot-search huggingface dataset:
The “Pirate Sign” in Fibrous Dysplasia
Authors: Amit Singnurkar, Chris Rush
Journal: Clinical Nuclear Medicine (2006)

Fibrous dysplasia commonly involves the skull in both its monostotic and polyostotic variants. We present two cases of fibrous dysplasia involving the sphenoid wing, which were strikingly similar in their bone scan appearance. Both patients demonstrated intense increased uptake of Tc-99m MDP in a pattern reminding us of a "pirate wearing an eyepatch." We propose that this characteristic appearance of fibrous dysplasia of the sphenoid wing be called the "pirate sign." A review of the literature revealed several other pathologic conditions that have been reported to involve the sphenoid bone and should be considered in the differential diagnosis of abnormal bone tracer uptake in this region.
The relative prevaleece of wild hepatitis B virus and its nutant unable to secrete WBeAg condition the course and outcome of ceronic infection of hepatitis B and delta viruses
Authors: M.P. Bronetto, E. Chiaberge, F. Oliveri, M. Baldi, A. Departini, L.N. Pizetto, G. Varae, F. Bonino
Journal: Journal of Hepatology (1990)
Proceedings: Joint formation in culture.
Authors: K T Rajan, H J Merker
Journal: Annals of the Rheumatic Diseases (1975)

The object of the research was to shed light on the factors concerned in the formation of synovial joints, with specific reference to the possible role of movement.The digits of human embryos (8-12 weeks) were maintained in organ culture (Trowell, 1954; Dingle, Fell and Lucy, 1966; Rajan and Hopkins, 1970) in the presence of synthetic medium BGJ (Biggers, Gwatkin, and Heuner, 1961) containing 15 % fetal calf serum (Flow Laboratories) and 150 uigfml ascorbic acid (Reynolds, 1966).In the young fetus, 10 weeks and under, the digits consist of a cartilagenous bar.After 1O days in culture the joint cavity appeared and this was in the absence of movement.There was evidence of material in the joint cavity, which was acid mucopolysaccharide in nature, with occasional cells showing pyknotic nuclei lining the cavity.Under the electron microscope there was single cell necrosis with evidence of loss of glycosaminoglycans, some areas showing aggregation of this material as seen with ruthenium red stained sections.So far 76 explants have been examined and the evidence suggests that the following factors may be responsible in part, if not wholly, in the formation ofjoints: (a) Necrosis ofcells in areas undergoing joint differentiation.(b) Altera- tions in glycosaminoglycans.As the organ cultures are devoid of blood supply, nervous control, and movement, these factors may not be essential to the formation and differentiation of joint cavity.
Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor–stroma interactions
Authors: Lirija Alili, Maren Sack, Ajay S. Karakoti, Sarah Teuber, Katharina Puschmann, Suzanne M. Hirst, Christopher M. Reilly, Klaus Zanger, Wilhelm Stahl, Soumen Das, Sudipta Seal, Peter Brenneisen
Journal: Biomaterials (2011)
Nosocomial Pseudobacteremia
Authors: Richard A. Kaslow
Journal: JAMA (1976)

<i>Pseudomonas cepacia</i>or<i>Enterobacter</i>species or both were isolated from blood cultures of 79 patients in a community hospital between April 1971 and March 1972. No common exposures other than venipuncture correlated with positive blood cultures.<i>Pseudomonas cepacia</i>, Enterobacter, and other Gram-negative enteric bacteria were cultured from aqueous benzalkonium chloride used for skin antisepsis prior to ordinary and blood culture venipuncture. Contamination of blood cultures by organisms from the antiseptic most likely accounted for positive cultures in 35 of 38 patients (92%) with<i>P cepacia</i>. The remaining three patients had repeated blood cultures positive for P cepacia and circumstantial clinical evidence of bacteremia; they may have contracted disease through exposure to the contaminated antiseptic. Substitution of an iodine-alcohol antiseptic abruptly reduced the isolation of<i>P cepacia</i>and Enterobacter. (<i>JAMA</i>236:2407-2409, 1976)
Munchausen's Syndrome Simulating Torsion Dystonia
Authors: M. L. Batshaw, R. C. Wachtel, A. W. Deckel, P. J. Whitehouse, H. Moses, L. J. Fochtman, R. Eldridge
Journal: New England Journal of Medicine (1985)

Torsion dystonia (dystonia musculorum deformans) is a movement disorder that may be genetic, environmental, or idiopathic in origin.1 The hereditary forms usually begin in childhood or adolescence with involuntary posturing of the foot or hand in the autosomal recessive form and with trunk or neck posturing in the rarer autosomal dominant form.2 Both forms may progress over years to produce contortions of the entire body. The diagnosis of torsion dystonia is based on clinical observations and family history, since no specific biochemical or anatomic abnormality has been identified.Torsion dystonia must be differentiated from other movement disorders, such as Wilson's . . .
Points from letters: Smoking and mortality in British doctors
Authors: M A Kastenbaum
Journal: BMJ (1977)

should be deprived of benefit from their husbands' war service.Interest at 3-50o compound, without tax relief, payable to secure war service pension compares very unfavourably with the miserable 210O simple-taxable-paid since 1948 on our compensation for loss of goodwill.A colleague of mine with six years of war service recently wrote to the appropriate department of the Ministry of Defence seeking confirmation of the dates of his war service.I understand th'at the reply
Child Health, Developmental Plasticity, and Epigenetic Programming
Authors: Z. Hochberg, R. Feil, M. Constancia, M. Fraga, C. Junien, J.-C. Carel, P. Boileau, Y. Le Bouc, C. L. Deal, K. Lillycrop, R. Scharfmann, A. Sheppard, M. Skinner, M. Szyf, R. A. Waterland, D. J. Waxman, E. Whitelaw, K. Ong, K. Albertsson-Wikland
Journal: Endocrine Reviews (2010)

Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.
Hospitals need encouragement to become part of integrated care, report says
Authors: N. Hawkes
Journal: BMJ (2013)

Healthcare needs to change radically in the next five years, a group of healthcare executives and clinicians brought together by KPMG has agreed. But many in the sector still behaved as though change was the responsibility of others, their own organisations needing only minor nips and tucks, they said.

Calling for “an act of courage and committed leadership,” KPMG’s report of discussions held in Rome in October last year says that it is time for major and transformational reform, not just cosmetic adjustment.

The report,1 whose findings were to be presented this week at the International Forum on Quality and Safety in Healthcare in London by Mark Britnell, chairman of global health at KPMG, identifies converging pressures on healthcare systems throughout the world.

Firstly, there is a shift from volume to value, as ways are sought …
Physicians with Physical Impairment
Authors: FRANK ZONDLO
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 March 1983Physicians with Physical ImpairmentFRANK ZONDLO, M.D.FRANK ZONDLO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-411_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: For the past 2 years, we have been compiling a resource directory for physicians with physical impairments. The work is funded by the St. Paul-Ramsey Hospital Medical Education and Research Foundation. The purpose is to list physicians with various physical disabilities willing to provide information and referral services to other physicians with the same disability.The biggest problem we have encountered is poor participation. To date we have placed advertisements in over 100 major medical journals and have had responses from fewer than 200 physicians. The poor response appears due to the use of inappropriate terminology in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Paul-Ramsey Hospital Medical and Research Foundation 640 Jackson Street; St. Paul, MN 55101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1983Volume 98, Issue 3Page: 411-411KeywordsDisabilitiesMedical education Issue Published: 1 March 1983 PDF downloadLoading ...
The effect of a recombinant elastin-mimetic coating of an ePTFE prosthesis on acute thrombogenicity in a baboon arteriovenous shunt
Authors: Sumanas W. Jordan, Carolyn A. Haller, Rory E. Sallach, Robert P. Apkarian, Stephen R. Hanson, Elliot L. Chaikof
Journal: Biomaterials (2006)
Role of the High Affinity Immunoglobulin E Receptor in Bacterial Translocation and Intestinal Inflammation
Authors: David Dombrowicz, Sophie Nutten, Pierre Desreumaux, Christel Neut, Gérard Torpier, Marc Peeters, Jean-Frédéric Colombel, Monique Capron
Journal: The Journal of Experimental Medicine (2000)

A role for immunoglobulin E and its high affinity receptor (FcεRI) in the control of bacterial pathogenicity and intestinal inflammation has been suggested, but relevant animal models are lacking. Here we compare transgenic mice expressing a humanized FcεRI (hFcεRI), with a cell distribution similar to that in humans, to FcεRI-deficient animals. In hFcεRI transgenic mice, levels of colonic interleukin 4 were higher, the composition of fecal flora was greatly modified, and bacterial translocation towards mesenteric lymph nodes was increased. In hFcεRI transgenic mice, 2,4,6-tri-nitrobenzenesulfonic acid (TNBS)-induced colitis was also more pronounced, whereas FcεRI-deficient animals were protected from colitis, demonstrating that FcεRI can affect the onset of intestinal inflammation.
Nitrous Oxide Analgesia-Reply
Authors: S. J. Montgomery
Journal: JAMA (1980)

In Reply.—  Dr Hindin raises valid points that were considered by us in preparing our report. We are currently measuring the levels of N 2 O that accumulate in the mobile unit but do not have enough data at this time for an estimate of importance. The referenced article by Bruce and Bach 1 allowed personnel to breathe trace gases for four hours at a time. The average time of transport in our series was 11 minutes. We do agree that every effort should be made to minimize the exposure to trace anesthetic gases.  Few, if any, drugs that provide potent analgesia should be classified as benign. This technique is one of the best, we think, for providing potent analgesia while minimizing side effects as it is self-administered and limited by requiring conscious effort on the part of the patient. Clinically, the effects on patients in pain, as opposed to tranquil
Association of Pain and Itch With Depth of Invasion and Inflammatory Cell Constitution in Skin Cancer
Authors: Gil Yosipovitch, Kyle C. Mills, Leigh A. Nattkemper, Ashley Feneran, Hong Liang Tey, Brett M. Lowenthal, Daniel J. Pearce, Phillip M. Williford, Omar P. Sangueza, Ralph B. D’Agostino
Journal: JAMA Dermatology (2014)

This study highlights a simple bedside evaluation of itch and pain for suspicious skin lesions.To examine the correlation of pain and itch with histologic features of skin cancers.This large, prospective, clinicopathologic study enrolled patients who filled out questionnaires that assessed itch and pain intensity of their skin tumors at the time of excision. Study participants were from the patient population presenting to the Department of Dermatology surgical unit at Wake Forest University Baptist Medical Center from July 1, 2010, through March 31, 2011. Study participants included 268 patients, representing 339 histopathologically confirmed cutaneous neoplasms. The following skin cancer subtypes were represented in this analysis: 166 basal cell carcinomas, 146 squamous cell carcinomas, and 27 melanomas.Itch and pain associated with skin cancer at the time of excision ranked on an 11-point (score range, 0-10) numerical visual analog scale and histopathologic analysis for each neoplasm (assessment of the amount and type of inflammation, ulceration, perineural invasion, and depth of invasion).The prevalence of itch and pain across all skin cancers was 36.9% and 28.2%, respectively. However, these symptoms were mostly absent in melanomas. Pain intensity was significantly associated with the degree of inflammation (mild or none vs moderate or marked; P < .001), presence of neutrophils in the inflammatory infiltrate (predominantly mononuclear vs mixed or neutrophilic; P = .003), presence of eosinophils (present vs absent; P = .007), ulceration (yes vs no; P = .003), perineural invasion (yes vs no; P < .001), depth of invasion (P = .001), and largest diameter length of skin lesion (P < .003). Itch intensity was significantly associated with the degree of inflammation (mild or none vs moderate or marked; P = .001) and the presence of eosinophils (present vs absent; P = .02).These findings support the theory that itch emanates from the upper layers of the skin, whereas pain is associated with deeper processes. This study also reports that a simple bedside assessment for the presence and intensity of pain or itch is an easily implementable tool for physicians evaluating suspicious skin lesions.
Indications for the use of endoscopic mucosal resection for early gastric cancer in Japan: a comparative study with endoscopic submucosal dissection
Authors: S. Nakamoto, Y. Sakai, J. Kasanuki, F. Kondo, Y. Ooka, K. Kato, M. Arai, T. Suzuki, T. Matsumura, D. Bekku, K. Ito, T. Tanaka, O. Yokosuka
Journal: Endoscopy (2009)

Background and study aims: Endoscopic submucosal dissection (ESD) has been reported to produce excellent treatment results for early gastric cancer. In terms of lesions that previously met the criteria for endoscopic mucosal resection (EMR), there is now controversy about which of the two methods is superior, and whether the two methods are comparable.
Presenilin-Mediated Modulation of Capacitative Calcium Entry
Authors: Andrew S Yoo, Isaac Cheng, Sungkwon Chung, Tallessyn Z Grenfell, Hanmi Lee, Eunju Pack-Chung, Melissa Handler, Jie Shen, Weiming Xia, Giuseppina Tesco, Aleister J Saunders, Kai Ding, Matthew P Frosch, Rudolph E Tanzi, Tae-Wan Kim
Journal: Neuron (2000)
The Ghost of GPEP Yet to Be
Authors: STEVEN L. BERK
Journal: Annals of Internal Medicine (1987)

Ad Libitum1 March 1987The Ghost of GPEP Yet to BeSTEVEN L. BERK, M.D.STEVEN L. BERK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-484 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis was to be an extraordinary meeting. Several strange figures sat around the table, like children, yet not so like children as old men, viewed through some supernatural medium. Their hair was white; their white coats said they were all physicians. There was an air of dignity and of sadness. A voice said, "The committee's final report will be read: a Report of the Panel on General Professional Education of Physicians (GPEP) for the Twenty-Second Century—presented December 24 of the year 2086."Recommendation 1. Medical faculties should establish the role of the student as an advocate for optimal patient care... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEVEN L. BERK, M.D.Affiliations: Johnson City, Tennessee PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1987Volume 106, Issue 3Page: 484-484KeywordsChildrenPatient advocacy ePublished: 1 December 2008 Issue Published: 1 March 1987 PDF downloadLoading ...
Effect of Beta-Adrenergic Blockade on Coronary Blood Flow
Authors: P. D. Stein, H. L. Brooks, J. L. Matson, J. W. Hyland
Journal: Cardiovascular Research (1968)

Propranolol caused a reduction of left circumflex coronary blood flow and increased coronary resistance in open-chest anaesthetized dogs. Similar results were shown at rest and during exercise produced by repetitive electrical stimulation of the leg muscles. Diminished coronary flow occurred in association with diminished left ventricular work and a diminished product of arterial mean pressure and heart rate. This suggests that myocardial oxygen consumption decreased and may have been responsible for the diminished coronary flow.
Severely hyperkeratotic erythroderma associated with Hodgkin's disease: does a high serum level of granulocyte-colony stimulating factor contribute to formation of skin lesions?
Authors: Ken Arita, Masashi Akiyama, Toshiya Sakai, Hiroshi Shimizu, Ken Arita, Masashi Akiyama, Toshiya Sakai, Hiroshi Shimizu
Journal: Journal of the American Academy of Dermatology (2003)
Effects of nutrient intake, surgery, sepsis, and long term administration of steroids on muscle function.
Authors: W Brough, G Horne, A Blount, M H Irving, K N Jeejeebhoy
Journal: BMJ (1986)

The stimulated contraction-relaxation characteristics of the adductor pollicis muscle were used to assess nutritional state in patients and healthy controls. In both groups insufficient nutrition resulted in abnormal muscle function. The ratio of force of contraction at 10 Hz to that at 20 Hz yielded the best combination of sensitivity (87%) and specificity (82%). Sepsis resulted in abnormal muscle function, but the changes were easily distinguishable from those in subjects taking an inadequate diet. Long term administration of steroids, trauma, and surgery had no effect on muscle function. A prospective study of 11 malnourished patients with abnormal muscle function showed that all variables of muscle function returned to normal values with total parenteral nutrition. This reversal correlated significantly with the duration of parenteral nutrition and occurred before any change in anthropometric variables or plasma albumin concentration. Muscle function studies are sensitive and specific indicators of malnutrition; results depend on energy intake but are not influenced by administration of steroids, trauma, or surgery.
Leiomyomata: heritability and cytogenetic studies
Authors: A. H. Ligon
Journal: Human Reproduction Update (2001)

Leiomyomata represent the most common gynaecological tumour in women of reproductive age, and are the primary indication for hysterectomy in the USA. Cytogenetic and genetic studies have, in recent years, advanced our understanding of the aetiology of these tumours. Cytogenetic aberrations involving chromosomes 6, 7, 12 and 14 constitute the major chromosomal abnormalities seen in leiomyomata, and suggest the possibility that disruption or dysregulation of the genes HMGIC and HMGIY may contribute to the development of these tumours. Based on the finding of a variety of chromosomal aberrations detected in fibroids, other genes with fundamental roles in the pathobiology of uterine leiomyomata await identification. Furthermore, the incidence of fibroids has been shown to be greater in African-American women than in Caucasian women. The existence of a heritability component of uterine leiomyomata has been further implicated by twin-pair studies and the existence of familial forms of leiomyomata, both of which suggest an inherited diathesis for leiomyomata formation. This paper will review the cytogenetic aberrations and gene expression, with respect to their contributions to the pathogenesis of leiomyomata, and also summarize the current understanding of heritability of these tumours.
Reductive Activation of Mitomycin C: A Delicate Balance
Authors: James H. Doroshow
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Reductive Activation of Mitomycin C: A Delicate Balance Get access James H. Doroshow James H. Doroshow Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 15, 5 August 1992, Pages 1138–1139, https://doi.org/10.1093/jnci/84.15.1138 Published: 05 August 1992 Article history Received: 02 July 1992 Accepted: 02 July 1992 Published: 05 August 1992
Safety of investigative bronchoscopy in the Severe Asthma Research Program
Authors: Wendy C. Moore, Michael D. Evans, Eugene R. Bleecker, William W. Busse, William J. Calhoun, Mario Castro, Kian Fan Chung, Serpil C. Erzurum, Douglas Curran-Everett, Raed A. Dweik, Benjamin Gaston, Mark Hew, Elliot Israel, Martin L. Mayse, Rodolfo M. Pascual, Stephen P. Peters, Lori Silveira, Sally E. Wenzel, Nizar N. Jarjour
Journal: Journal of Allergy and Clinical Immunology (2011)
Cardiac Arrest in the Critically Ill
Authors: SAMUEL J. CAMARATA, MAX HARRY WEIL, PAUL K. HANASHIRO, HERBERT SHUBIN
Journal: Circulation (1971)

The events preceding cardiac arrest were investigated in 132 critically ill patients on the basis of the hemodynamic, respiratory, and metabolic status prior to cardiac arrest. Approximately one-half of the patients had respiratory acidosis prior to cardiac arrest and only one of these patients ultimately survived. An additional one-fourth had metabolic acidosis due to progressive perfusion failure (shock), and none survived. In the remaining one-fourth, an immediate catastrophic and potentially preventable event accounted for cardiac arrest, and all but one of the long-term survivors were included in this group. In thirteen patients, obstruction or dislodgment of endotracheal tracheostomy tubes, or interruption of ventilation, was recognized as the immediate cause. In an additional 20 patients, cardiac arrest was associated with an adverse effect of a drug. Twelve instances of cardiac arrest were associated with central venous injection of aminophylline. The initial cardiac resuscitation attempt was effective in 38% of patients. However, the majority of patients who survived the first episode succumbed after a second or third episode. The cumulative survival was disappointingly small. Only six patients, or 5% of the total group of 132 patients, were long-term survivors. These data may provide the basis for more restricted use of routine and repetitive resuscitative measures particularly for elderly patients in whom acidemia is due to progressive ventilatory or circulatory failure.