tbuckley/cabot-search huggingface dataset:
"Phenistix" Testing for Babies
Authors: J. G. Scott
Journal: BMJ (1963)

A 56-year-old man who was a Jehovah9s Witness with an advanced directive against autologous procedures developed acute kidney injury needing renal replacement therapy while he was intubated and ventilated on the intensive care unit. He was being treated for hyperosmolar hyperglycaemic state. He also had a healing laparotomy wound, having undergone a splenectomy less than a month ago following a road traffic accident. His hyperkalaemia and metabolic acidosis were refractory to medical treatment. As he became oligoanuric, decision was taken to carry out acute peritoneal dialysis (PD) by inserting a Tenckhoff catheter in his abdomen using peritoneoscopic technique. The patient was started on automated PD without any complications. His urine output gradually improved, and his renal function eventually recovered. On discharge from hospital, his renal function was within normal range, and he had no abdominal complications from the acute PD.
International consensus report on the investigation and management of primary immune thrombocytopenia
Authors: Drew Provan, Roberto Stasi, Adrian C. Newland, Victor S. Blanchette, Paula Bolton-Maggs, James B. Bussel, Beng H. Chong, Douglas B. Cines, Terry B. Gernsheimer, Bertrand Godeau, John Grainger, Ian Greer, Beverley J. Hunt, Paul A. Imbach, Gordon Lyons, Robert McMillan, Francesco Rodeghiero, Miguel A. Sanz, Michael Tarantino, Shirley Watson, Joan Young, David J. Kuter
Journal: Blood (2009)
Teaching Psychosomatic Medicine: Utilizing Concurrent Perspectives
Authors: Thomas N. Wise
Journal: Psychotherapy and Psychosomatics (1993)

Teaching psychosomatic medicine is a challenge in the contemporary medical culture that rewards technology and empiricism. The biopsychosocial model of disease offers an overview about psychosomatic medicine for educating students at all levels of medical training. The teacher can then utilize the various perspectives found in psychiatry to emphasize that the medical model of disease states which concur with the meaningful elements of patient's life narratives, their personality style and possible motivated behaviors fully illuminates psychosomatic illness.
Aspirin Use Up . . .
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological determinism versus the concept of a person
Authors: Robert Miller
Journal: Behavioral and Brain Sciences (1999)

Rose presents an important critique of the determinism and reductionism of modern biology. However, such trends are probably temporary aberrations in the development of science. Another form of determinism which has deeper roots is emerging from modern studies of brain dynamics. To reconcile this evidence with the concept of a “person” will require more radical rethinking of our received notion of natural law.
Paediatrics in the Tropics: Current Review
Authors: S. L. Hammar
Journal: JAMA (1983)

This review and update is designed for the pediatrician working in developing countries. It is a well-organized collection of topics by authorities in their respective fields based on a tropical pediatrics update course, sponsored by the Liverpool School of Tropical Medicine during the recent International Year of the Child. The chapters are well written, well organized, and well referenced. Although it is always difficult to capture the flavor and ambience of a symposium in which clinical demonstrations, seminars, and group interchange augment the formal lectures, the editor has done a good job of extracting those topics with particular relevance to tropical settings. The book is divided into sections covering neonatology, general pediatrics, infectious and parasitic diseases, and child health services adapted to tropical and developing areas, It is difficult to review a highly advanced field such as neonatology, which has become synonymous with sophisticated equipment and technology. While still making
Letter by Heidrich et al Regarding Article, “Inositol 1,4,5-Trisphosphate Receptors and Human Left Ventricular Myocytes”
Authors: Felix M. Heidrich, Ruth H. Strasser, Stephan Wiedemann
Journal: Circulation (2014)

It was with great interest that we read the comprehensive study by Signore et al 1 addressing the impact of inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) on the electromechanical behavior of mouse cardiomyocytes and human ventricular myocardium.Published in the September 17, 2013, issue of Circulation, this article provides compelling evidence that the G αq -protein-coupled receptor (GPCR)/InsP3R axis plays a critical role in the regulation of cardiomyocyte calcium homeostasis, electric stability, and contractile performance.The authors demonstrate that GPCR agonists generate InsP3, which activates InsP3Rs to liberate calcium from internal stores, resulting in decreased resting membrane potential, prolongation of myocyte action potential, and the occurrence of early afterdepolarizations.These mechanisms cause electric instability and contractile abnormalities.
Attitudes of European physicians, nurses, patients and families regarding end-of-life decisions: the ETHICATT study. Reply to A.M. Vrakking
Authors: Charles L. Sprung, Sara Carmel, Mario Baras, Simon L. Cohen, Paulo Maia, Albertus Beishuizen, Daniel Nalos, Ivan Novak, Mia Svantesson, Julie Benbenishty, Beverly Henderson
Journal: Intensive Care Medicine (2007)
My Best Work
Authors: Susan L. Norris
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS
Authors: Elvin A. Kabat, Harold Baer, Ada E. Bezer, Vesta Knaub
Journal: The Journal of Experimental Medicine (1948)

1. The effect of heating at varying pH on the cross-reactivity of hog blood group A and 0 substances with Type XIV antibody has been investigated. The hydrolysis of blood group A, B, and O substances from hog and human sources at pH 1.5-1.8 resulted in destruction of blood group activity and a marked increase in cross-reactivity with Type XIV antipneumococcus horse serum. 2. Analysis revealed the liberation of reducing sugar, most of which was dialyzable. It was further shown that the major part of the reducing sugar was fucose with small amounts of free and polymerized galactose and glucosamine. Non-glucosamine nitrogen, probably amino acids, also was found in the dialysate. 3. Paper chromatographic separation of the concentrated dialysate confirmed the presence of fucose and showed that the majority of the galactose and glucosamine occurred in polymeric form. 4. Quantitative analysis of the substances isolated from the paper showed good recovery of the various components, indicating that practically all of the material in the dialysate could be accounted for. 5. The methylpentose of human blood group A substance was identified as fucose. 6. The structure of the blood group substances is interpreted in terms of these results.
Forecasting Drug Effects in Man from Studies in Laboratory Animals
Authors: John T. Litchfield
Journal: JAMA (1961)

Experiments on animals are the most important source of data for predicting the effects of administering a new drug to patients. Nevertheless, the predictive value of such experiments is limited. In the present retrospective study of 6 drugs of different types, it is shown that many of the most serious side effects that can result when a drug is given to man were not predictable from observations on dogs or rats. From an initial list of signs of toxicity that could occur in man, 39 physical signs were retained that could also be observed in the dog or the rat, or both. Analysis showed that effects on man could be predicted better from observations on dogs than from those on rats.
P5-11-15: Should HER-2 Score 0/1+ Breast Cancer Cases Be Retested by In-Situ Hybridisation? Results of a Multicenter Retesting Study.
Authors: AM Reiner-Concin, S Lax, P Regitnig, C Kronberger, Z Jasarevic, S Bogner
Journal: Cancer Research (2011)

Abstract Background: HER-2 status is vital for selection of appropriate therapy for breast cancer patients. Accuracy of immunohistochemistry (IHC) varies with a major problem of false negative testing. To assess the false negative rate retesting by in situ hybridisation was performed on a group of primary breast cancers in which according to guidelines routine retesting is not recommended. Material and Methods: 570 breast cancers from 5 pathology departments scored 0/1+ by IHC (HercepTest or 4B5-antibody) were retested by HER2−Dual-SISH (BDISH) in a central laboratory. CAP/ASCO guidelines were applied. Cases showing ratios in the amplified or equivocal range by BDISH were further analysed by fluorescence in situ hybridisation (FISH) using Pathvysion® and ZytoLight® and retested centrally by IHC using 4B5 antibody (Ventana). Results: 25/570 cases (4.38%) were amplified by BDISH, the majority with low level amplification (ratios ≤ 3.26). Only two cases showed high level ratios (6.35 and 6.48). 17/570 cases (2.98%) showed ratios by BDISH in the equivocal range (1.8 — 2.2). 24 amplified and 17 equivocal cases underwent further retesting. In one case no tumor tissue was available for further testing. On further testing 17/24 (71%) BDISH-amplified cases showed IHC scores 2+/3+ and 7/24 (29%) cases showed IHC scores 0/1+. Subsequently 3/13 score 2+ cases were amplified by Pathvysion® and 9/13 by ZytoLight®. 3/4 score 3+ cases were amplified by both FISH assays. In case of amplification ratios of BDISH and both FISH assays appeared to be in the same range. Only 2/17 BDISH-equivocal carcinomas were confirmed equivocal by Pathvysion® and 6/17 were confirmed equivocal by ZytoLight®. All other BDISH-equivocal cases were non-amplified by both FISH assays. Discrepant results between different methods could partly be caused by interobserver variability. This question is currently under investigation. Overall, after multistep retesting amplification occurred in only 17 cases (2.98%). Discussion: Amplification is rare in immunohistochemically HER-2 negative breast carcinomas and occurred predominantly at low level in our study. Low level amplification seemed to be diagnosed more frequently by BDISH compared with FISH. Since clinical data demonstrate a benefit of therapy even in carcinomas with low level amplification the identification of these carcinomas might be of interest. Conflicts of Interest: The study was supported by Roche Austria GmbH. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-11-15.
Kjellin Syndrome: Long-term Neuro-ophthalmologic Follow-up and Novel Mutations in the SPG11 Gene
Authors: Bernard Puech, Arnaud Lacour, Giovanni Stevanin, Bruno G. Sautiere, David Devos, Christel Depienne, Elodie Denis, Emeline Mundwiller, Didier Ferriby, Patrick Vermersch, Sabine Defoort-Dhellemmes
Journal: Ophthalmology (2010)
What could we have done for her now?
Authors: F. Moir
Journal: BMJ (2008)

In the 1960s my mother had three episodes of postnatal depression. I have always known this must have had a significant effect on herself and my father, but recently I have recognised that the depression undoubtedly also had an effect on my siblings and me, and perhaps it could also affect my children in the future. Maybe it all started with one of my grandparents a long time ago, but no one ever spoke about it. What previously I had considered a small family incident of mental illness I now see as something more significant, stretching over generations and passing on vulnerabilities. I wonder whether it made me the person and practitioner I am today?

I have looked again at two photos of my mother and me, the first taken on the day I was born. There I am, a small bundle in an old fashioned blanket, and she is holding me as if I am the most precious thing and smiling sideways at the camera. In the second photo a few months later she looks …
Book: The Change: Women, Ageing and the Menopause
Authors: S. Coney
Journal: BMJ (2002)

First published in 1991 by Hamish Hamilton Rating: ![Graphic][1]</img> Germaine Greer is fated to be a prophet with few followers. From the knickerless groupie of the free love days, exhorting women to explore their own genitals, to the middle aged woman advocating joyful celibate cronehood, Greer's vision has always been idiosyncratic. Her interpretation of sexual liberation has evolved as she herself has aged, but she has not always succeeded in taking women with her. In The Change: Women, Ageing and the Menopause she argued that women would come into their true selves when middle age disqualified them sexually. She urged women to use their invisibility to seize their own power and she warned them of the Evil Empire—gynaecologists and pharmaceutical companies, peddling the panacea of postmenopausal hormones. It is now 11 years since Greer's book was first published. In that time hormone replacement therapy has been normalised as what women do at the menopause. In the United States, this started happening a long time … [1]: /embed/inline-graphic-1.gif
Procedures for Making Medical Decisions for Incompetent Adults
Authors: Joanne Lynn
Journal: JAMA (1992)

In this issue ofTHE JOURNAL, Emanuel and Emanuel<sup>1</sup>present an array of concerns about the justifications for, and the effectiveness of, proxy decision making for incompetent adults. Although well founded, these concerns should not dictate any diminution of the current enthusiasm for proxy (or "surrogate") decision making. A morally justifiable and pragmatic policy for decision making for incompetent adults, at this point, will have to rely heavily on appointed and family proxies. See also p 2067. Each of us faces a high likelihood of being incapable of managing our own affairs sometime before we die. Decisions that arise at such a time still must be made, and the alternative strategies are few: (1) by proxies (including family and courts, with or without guidance from the patient in advance), (2) in advance by the patient, or (3) by community and professional guidelines. Each of these offers some likely advantages
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2
Authors: Jonas S. Jutzi, Ruzhica Bogeska, Gorica Nikoloski, Corina A. Schmid, Thalia S. Seeger, Frank Stegelmann, Sven Schwemmers, Albert Gründer, Jan C. Peeken, Monika Gothwal, Julius Wehrle, Konrad Aumann, Kamar Hamdi, Christine Dierks, Wei Wang, Konstanze Döhner, Joop H. Jansen, Heike L. Pahl
Journal: The Journal of Experimental Medicine (2013)

The molecular etiology of myeloproliferative neoplasms (MPNs) remains incompletely understood, despite recent advances incurred through the discovery of several different mutations in MPN patients. We have recently described overexpression of the transcription factor NF-E2 in MPN patients and shown that elevated NF-E2 levels in vivo cause an MPN phenotype and predispose to leukemic transformation in transgenic mice. We report the presence of acquired insertion and deletion mutations in the NF-E2 gene in MPN patients. These result in truncated NF-E2 proteins that enhance wild-type (WT) NF-E2 function and cause erythrocytosis and thrombocytosis in a murine model. NF-E2 mutant cells acquire a proliferative advantage, witnessed by clonal dominance over WT NF-E2 cells in MPN patients. Our data underscore the role of increased NF-E2 activity in the pathophysiology of MPNs.
Potentiation of urinary atrial natriuretic peptide interferes with macula densa function
Authors: M Haloui
Journal: Cardiovascular Research (2001)

Objectives: Neutral endopeptidase (NEP) inhibition potentiated the renal action of Atrial Natriuretic Peptide (ANP) and was associated with appearance of the peptide in the urine, providing evidence of protection of the filtrated peptide along the course of the nephron. The macula densa, composed of epithelial cells, receives ionic information from the urinary compartment via Na–K–2Cl cotransport and influences renin secretion by the myoepithelioïd cells in the afferent arteriole. bNOS constitutively expressed in the epithelial cells of the macula densa is involved in this feed-back. NEP inhibition was associated with the absence of any increase in renin secretion. The hypothesis is that potentiation of urinary ANP by NEP inhibition could limit renin secretion by directly or indirectly targeting the macula densa in vivo. Methods and results: We tested the interaction between NEP inhibition (candoxatril) and Na–K–2Cl inhibition (bumetanide) on electrolyte and ANP urinary excretion, renin secretion, macula densa activity (NADPH diaphorase activity and bNOS mRNA) and TSC-1 mRNA expression in the renal cortex and BSC-1 in the renal medulla of rats treated for 5 days. Bumetanide increased urinary electrolyte excretion whereas candoxatril did not. Candoxatril increased urinary ANP and cyclic GMP excretion. Bumetanide increased renin and aldosterone secretion whereas candoxatril decreased renin secretion. This effect on renin release was associated with an increase in macula densa NADPH diaphorase activity in the bumetanide-treated group which was blunted by candoxatril. Lastly, bumetanide increased TSC-1 mRNA expression in the cortex and this effect was blunted by candoxatril. Conclusion: These results suggest that potentiation of ANP by NEP inhibition could interfere with tubular function at different levels and limit renin secretion by a urinary pathway involving macula densa activity.
Substance Abuse: A Comprehensive Textbook
Authors: Alan L. Krueger
Journal: JAMA (1993)

Having reviewed the initial volume,<i>Substance Abuse: Clinical Problems</i><i>and Perspectives</i>, I was pleased to find that the second edition of this work,<i>Substance Abuse: A Comprehensive Textbook</i>, has continued the tradition of excellence established in the first work. The explosive growth of knowledge in this field is accurately reflected in the breadth and depth of the topics covered in this volume. As in the original work, there are 11 parts expanded to contain 80 chapters. The first part gives us historical background and epidemiological perspectives on alcohol and drug abuse. In part 2 are discussed the determinants of substance abuse, with excellent coverage of biopsychosocial components, including genetics, psychobiology, conditioned responses, and psychodynamic and sociocultural aspects. Part 3 includes a comprehensive discussion of the various substances of abuse, including chapters on eating disorders and anabolic steroids. Evaluation and early treatment, covering current concepts of diagnosis and classification, detoxification, laboratory
Antacids Inhibit Absorption of Cimetidine
Authors: William M. Steinberg, James H. Lewis, Debra M. Katz
Journal: New England Journal of Medicine (1982)

CURRENT recommendations for the treatment of peptic-ulcer disease call for cimetidine to be given with meals and at bedtime1 and for antacids to be taken between meals and at bedtime.2 Thus, these two medications may frequently be taken together at bedtime. In addition, many patients undoubtedly ingest cimetidine and antacids simultaneously during the day for the sake of convenience. Despite this practice, there is little information about whether or not commonly prescribed antacids available in the United States interfere with the absorption of cimetidine. Three European investigations have reported conflicting results regarding the effect of antacids on the bioavailability of . . .
The Role of Auscultation in the Differentiation of Fallot's Tetralogy from Severe Pulmonary Stenosis with Intact Ventricular Septum and Right-to-Left Interatrial Shunt
Authors: LOUIS VOGELPOEL, VELVA SCHRIRE
Journal: Circulation (1955)

A clinical and phonocardiographic study has been made of the murmurs and heart sounds in the differentiation of Fallot's tetralogy from severe pulmonary stenosis with intact septum and right-to-left interatrial shunt. A striking difference in the behaviour of the systolic murmur was found in the two conditions and this affords a new, simple bedside method of diagnosis. Important differences in the behaviour of the heart sounds were also found, but these are usually more difficult to evaluate clinically and may require special study.