Experiments With Phenylhydrazine†
Authors: Edgar V. Allen, Herbert Z. Giffin
Journal: Annals of Internal Medicine (1928)

Article1 March 1928Experiments With Phenylhydrazine†II. Studies On Renal and Hepatic Function and Erythropoiesis*EDGAR V. ALLEN, M.D., HERBERT Z. GIFFIN, M.D.EDGAR V. ALLEN, M.D.Search for more papers by this author, HERBERT Z. GIFFIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-9-677 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLevi (8) first remarked on the danger of inducing permanent changes in the liver by treating cases of polycythemia vera with phenylhydrazine. He reported a case in which 7.5 gm. of phenylhydrazine hydrate had been administered in eighteen months. Death occurred from erysipelas. Necropsy showed cirrhosis of the liver, but Levi did not consider the drug necessarily causal, as cirrhosis of the liver is often noted in cases of polycythemia vera untreated with phenylhydrazine. Studies of the function of the liver following the administration of phenylhydrazine have not been numerous. Brown and Giffin (1296) (3) were unable to demonstrate dye...Bibliography(1) EPPINGERKLOSS HK: Zur Therapie der Polyzytha̋mie. Therap. Monatsh., 1918, xxxii, 322-326. Google Scholar(2) OWEN T: A case of polycythemia vera with special reference to the familial features and treatment with phenylhydrazine. Bull. Johns Hopkins Hosp., 1924, xxxv, 258-262. Google Scholar(4) WELLS HG: The pathologic anatomy of hydrazine poisoning. Jour. Exper. Med., 1908, x, 457-464. CrossrefGoogle Scholar(5) ALTNOWCAREY HOJB: A case of polycythemia vera treated with phenylhydrazine hydrochloride with special reference to changes in blood morphology. Jour. Lab. and Clin. Med., 1927, xii, 597-606. Google Scholar(6) LEOPOLD SS: The treatment of polycythemia vera with phenylhydrazine. Med. Clin. N. Amer., 1926, x, 229-239. Google Scholar(7) LONG PH: Experimental anemia produced by phenylhydrazine derivatives. Jour. Clin. Investigation, 1926, ii, 329-342. CrossrefGoogle Scholar(8) LEVI E: Über die Ursache der Lebercirrhose bei Polycytha̋mie. Ztschr. f. klin. Med., 1924, c, 777-784. Google Scholar(9) STEALY : Personal communication. Google Scholar(10) BODANSKY M: The action of phenylhydrazine and some of its derivatives in producing liver injury as measured by the effect on levulose tolerance. Jour. Biol. Chem., 1924, lviii, 799-811. CrossrefGoogle Scholar(11) HUFFMAN LD: Metabolic studies in the treatment of polycythemia vera with phenylhydrazine. Arch. Int. Med., 1927, xxxix, 656-672. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *The material in this paper was presented in a thesis by Edgar V. Allen to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of M. S. in Medicine, 1928. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlkylpyridines and Miscellaneous Organic Nitrogen CompoundsAlkylpyridines and Miscellaneous Organic Nitrogen CompoundsCholesterol biosynthesis in rabbit blood and bone marrow: Effect of hematopoietic stimulation and dietary cholesterol 1 March 1928Volume 1, Issue 9Page: 677-682KeywordsCirrhosisDrugsGraduate medical educationHydratesLiverPolycythemia vera Issue Published: 1 March 1928 PDF downloadLoading ...