<i>Helicobacter pylori</i> and Idiopathic Thrombocytopenic Purpura
Authors: Giovanni Emilia, Mario Luppi, Giuseppe Torelli
Journal: Annals of Internal Medicine (2004)

Letters16 November 2004Helicobacter pylori and Idiopathic Thrombocytopenic PurpuraGiovanni Emilia, MD, Mario Luppi, MD, and Giuseppe Torelli, MDGiovanni Emilia, MDFrom University of Modena and Reggio Emilia, I-41100 Modena, Italy.Search for more papers by this author, Mario Luppi, MDFrom University of Modena and Reggio Emilia, I-41100 Modena, Italy.Search for more papers by this author, and Giuseppe Torelli, MDFrom University of Modena and Reggio Emilia, I-41100 Modena, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-10-200411160-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Franceschi and colleagues' interesting letter about the cross-reactivity between Helicobacter pylori and platelet antigens (1) contains some perplexities we would like to address. The authors reported that they re-investigated a group of patients from their 1998 study (2) whose platelet counts had increased “after eradication of CagA [cytotoxin-associated gene A]-positive H. pylori infection.” However, their 1998 paper does not mention anti-CagA antibodies (2). Did Franceschi and colleagues test archival specimens for them?Franceschi and colleagues' letter also stated that “no patient received treatment for ITP [idiopathic thrombocytopenic purpura].” Since the authors said in their previous paper that ...References1. Franceschi F, Christodoulides N, Kroll MH, Genta RM. Helicobacter pylori and idiopathic thrombocytopenic purpura [Letter]. Ann Intern Med. 2004;140:766-7. [PMID: 15126268] LinkGoogle Scholar2. Gasbarrini A, Franceschi F, Tartaglione R, Landolfi R, Pola P, Gasbarrini G. Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori [Letter]. Lancet. 1998;352:878. [PMID: 9742983] CrossrefMedlineGoogle Scholar3. Takahashi T, Yujiri T, Shinohara K, Inoue Y, Sato Y, Fujii Y, et al. Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori-associated chronic idiopathic thrombocytopenic purpura. Br J Haematol. 2004;124:91-6. [PMID: 14675413] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Modena and Reggio Emilia, I-41100 Modena, Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHelicobacter pylori and Idiopathic Thrombocytopenic Purpura Francesco Franceschi , Nicholas Christodoulides , Michael H. Kroll , and Robert M. Genta Helicobacter pylori and Idiopathic Thrombocytopenic Purpura Francesco Franceschi Metrics Cited byA Novel Design of Multi-epitope Vaccine Against Helicobacter pylori by Immunoinformatics Approach 16 November 2004Volume 141, Issue 10Page: 820KeywordsAntibodiesAntibody therapyAntigensAutoantibodiesHelicobacter pyloriIdiopathic thrombocytopenic purpuraPatientsPlateletsProteinsSteroids ePublished: 16 November 2004 Issue Published: 16 November 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...