tbuckley/cabot-search huggingface dataset:
ERRATUM: FACTOR VIII, NOT XIII
Authors: RICHARD B. SOLOMON
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 February 1969ERRATUM: FACTOR VIII, NOT XIIIRICHARD B. SOLOMON, M.D.RICHARD B. SOLOMON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-2-423 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:There is an error in the article entitled "Femoral Nerve Entrapment Secondary to a Heparin Hematoma," by Susens, Hendrickson, Mulder, and Sams (Ann. Intern. Med. 69: 575, 1968). The first sentence states ". . . patients with hemophilia (factor XIII deficiency.) . . ." It should be noted that hemophilia ordinarily refers to a factor VIII rather than a factor XIII deficiency. I suspect that this was a typographical error.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Queens Hospital Center Affiliation 82-68 164th St. Jamaica, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCarbohydrates 1 February 1969Volume 70, Issue 2Page: 423-423KeywordsHemophiliaHeparinNerves Issue Published: 1 February 1969 PDF DownloadLoading ...
Recent advances: Respiratory medicine
Authors: H. A M Kerstjens, H. J Groen, W. van der Bij
Journal: BMJ (2001)

Caring for patients with chronic obstructive pulmonary disease (COPD) will present a major challenge over the next decade. Due to a combination of factors including past and present smoking habits and an ageing population it is the only major chronic disease that is still associated with rising mortality. Rising rates of smoking in developing countries and the impact of women “catching up” with men's smoking habits will further affect the development of COPD, as well as lung cancer. This review focuses primarily on COPD, asthma, oncology, and lung transplantation, where in each case recent evidence has been, or is likely to be, associated with advances in clinical management.
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis
Authors: Benjamin Schattling, Karin Steinbach, Edda Thies, Martin Kruse, Aurélie Menigoz, Friederike Ufer, Veit Flockerzi, Wolfgang Brück, Olaf Pongs, Rudi Vennekens, Matthias Kneussel, Marc Freichel, Doron Merkler, Manuel A Friese
Journal: Nature Medicine (2012)
Surgery for Ischemic Mitral Regurgitation
Authors: Thoralf M. Sundt
Journal: New England Journal of Medicine (2014)

Defining the appropriate management of mitral regurgitation secondary to ischemic heart disease — as opposed to primary disease such as rheumatic or myxomatous degeneration — has proved elusive. Coronary artery disease is common, and so is associated mitral regurgitation, at least to some degree. The latter has been recognized as an unfavorable prognostic sign for more than 25 years1 and thus has been a target of surgical interest, with the goal of negating the adverse effects on late survival without paying too much of an up-front cost in terms of perioperative mortality.2 When the regurgitation is severe, debate has centered . . .
History and Perspectives of Cardiology: Catheterization, Angiography, Surgery and Concepts of Circular Control
Authors: E. Grey Dimond
Journal: JAMA (1982)

This small book comes from the Leiden University Press and presents the proceedings of the Einthoven Memorial meeting in Leiden, Holland, Nov 1-2, 1979. There is no loss from this delayed publication, for the book is a collection of memoirs of cardiovascular history. A handful of the originators of modern cardiology gathered and told of their own moments on stage: Lewis Dexter, Herbert Abrams, Richard Bing, Israel Steinberg, Helen Taussig, George Burch, Henry Swan, Donald Effler, and Arthur Guyton were the American spokesmen. As must happen when there is a head table (so to speak), there are always those who are so conspicuous by their absence that one feels a loss, even if they could have not been present. Mason Sones and Walt Lillihei are two giants whose absence from the volume hurts its significance. However, to read the reminiscent words of Brock, Crafoord, Bigelow, McMichael, and Castellanos, as examples,
Optimal Sequence of Tamoxifen and Aromatase Inhibitors to Prevent Bone Loss
Authors: Khalil Zaman, Beat Thuerlimann, Stefan Aebi
Journal: Journal of Clinical Oncology (2013)

the 3% difference in new osteoporosis of any grade between the arms signified more than 100 new cases in the anastrozole arm compared with the exemestane arm (Appendix Table A3).Again, if this difference were applied to a large number of women, it would translate into hundreds to thousands of new cases of osteoporosis.Results of our unpublished MA.27 bone mineral density substudy (presented at the American Society of Clinical Oncology's 2011 Annual Meeting) showed that at 12 years of therapy, there is less bone loss in the hips of women using exemestane without a previous diagnosis of osteoporosis and without preventive bisphosphonates than in those using anastrozole. 3Thus, on the basis of the lack of superiority in breast cancer efficacy outcomes of either drug over the other and a toxicity profile that showed that exemestane is at least as good or better than anastrozole, we maintain our claim that exemestane is another new, effective, and safe option for adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive breast cancer.
Cancer doctors told to become lobbyists
Authors: A. Kent
Journal: BMJ (1999)

Disillusioned medical staff should lobby their MPs for improvements in cancer services, according to Ian Gibson, Labour MP for Norwich North and chairman of the All-Party Group on Cancer.

Dr Gibson, former dean of biological sciences at the University of East Anglia, told a conference in Cambridge last week that he had been impressed by the efforts of the lobbyists he had seen at work in Washington. “Lobbying in the United States has led to a doubling in the cancer budget. However, lobbying is foreign to us in this country.

“My biggest disappointment is that some of the bodies who represent you don't lobby hard enough. You are also part of …
Peroxisome proliferator-activated receptor α regulates skin inflammation and humoral response in atopic dermatitis
Authors: Delphine Staumont-Sallé, Georges Abboud, Céline Brénuchon, Akira Kanda, Thomas Roumier, Céline Lavogiez, Sébastien Fleury, Patrick Rémy, Jean-Paul Papin, Justine Bertrand-Michel, François Tercé, Bart Staels, Emmanuel Delaporte, Monique Capron, David Dombrowicz
Journal: Journal of Allergy and Clinical Immunology (2008)
The Effect of Passive Smoking and Tobacco Exposure Through Breast Milk on Sudden Infant Death Syndrome
Authors: Hillary Sandra Klonoff-Cohen, Sharon Leigh Edelstein, Ellen Schneider Lefkowitz, Indu P. Srinivasan, David Kaegi, Jae Chun Chang, Karen J. Wiley
Journal: JAMA (1995)

<h3>Objective.</h3> —To examine the relationship between sudden infant death syndrome (SIDS) and smoking during pregnancy; postnatal tobacco smoke exposure from the mother, father, live-in adults, and day care providers; and postnatal smoke exposure from breast-feeding. <h3>Design.</h3> —Case-control study. <h3>Setting.</h3> —Five counties in Southern California. <h3>Participants.</h3> —A total of 200 white, African-American, Hispanic, and Asian parents of infants who died of SIDS between 1989 and 1992 were compared with 200 control parents who delivered healthy infants. Case infants were matched to control infants on the basis of birth hospital, birth date, gender, and race. All information was obtained from a detailed telephone interview and validated with medical records. <h3>Main Outcome Measures.</h3> —Risk of SIDS associated with passive smoking by the mother, father, live-in adults, and day care providers; smoking in the same room as the infant; total number of cigarettes smoked by all adults; and maternal smoking during the time period of breast-feeding. <h3>Results.</h3> —Conditional logistic regression resulted in overall adjusted odds ratios (ORs) for SIDS associated with passive smoke from the mother of 2.28, the father of 3.46, other live-in adults of 2.18, and all sources of 3.50 (95% confidence interval, 1.81 to 6.75), while simultaneously adjusting for birth weight, sleep position, prenatal care, medical conditions at birth, breast-feeding, and maternal smoking during pregnancy. A dose-response effect was noted for SIDS associated with increasing numbers of cigarettes, as well as total number of smokers. Breast-feeding was protective for SIDS among nonsmokers (OR=0.37) but not smokers (OR=1.38), when adjusting for potential confounders. <h3>Conclusions.</h3> —Passive smoking in the same room as the infant increases the risk for SIDS. Physicians should educate new and prospective parents about the risks of tobacco smoke exposure during pregnancy and the first year of the infant's life. (<i>JAMA</i>. 1995;273:795-798)
Critique and Cavil... (Sneeze I)
Authors: George X. Trimble
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some observations on attempts to measure appropriateness of care
Authors: N R Hicks
Journal: BMJ (1994)

In presenting and discussing the results of an observational study the greatest emphasis should be placed on bias and confounding * Confidence intervals should be relegated to a small part of both the results and discussion sections as an indication, but no more, of the possible influence of chance imbalance on the result * 90% Confidence intervals should be accepted as readily as 95% confidence intervals * The term "statistical significance" should not be used and P values should not be published in observational studies
EFFECTS OF BACTERIAL ENDOTOXIN ON WATER INTAKE, FOOD INTAKE, AND BODY TEMPERATURE IN THE ALBINO RAT
Authors: John E. Holmes, Neal E. Miller
Journal: The Journal of Experimental Medicine (1963)

Intraperitoneal injections of Escherichia coli endotoxin in albino rats produces a decrease in food and water intake and a drop in body temperature. The drop in temperature and in water intake is probably proportional to the size of the dose. Using a behavioral test in which animals are trained to press a bar at a steady rate for intermittent food or water reward, it is possible to demonstrate the sudden onset of the toxin effect at 30 to 45 minutes after injection. In any group of rats, all of whom were presumably exposed to E. coli, three types of response to toxin can be found: (a) Sharp reduction in water intake 30 minutes after injection. (b) Little or no change in intake or rate of working for water reward. (c) Immediate depression of work rate. These three types of reaction appear related to previous experience with the toxin. The "normal" or "inexperienced" reaction a was seen in animals who had not been given toxin before. The "protected" reaction b, with little or no effect of toxin injection on response rate was frequently found 4 to 5 days after a previous injection. The "susceptible" reaction c was found in three animals after 14 or more days had passed since a previous injection. Injections of toxin into the lateral hypothalamic region of four animals through implanted cannulae had no effect on the rate of bar pressing for water. Control injections of lidocaine blocked response rate completely for brief periods in three animals.
Aconitine-Induced Auricular Arrhythmias and Their Relation to Circus-Movement Flutter
Authors: BARBARA B. BROWN, GEORGE H. ACHESON
Journal: Circulation (1952)

Certain characteristics of aconitine-induced auricular arrhythmias in dogs and the responses of aconitine-induced flutter to various experimental procedures and to drugs are described. In certain experiments there was evidence that a secondary flutter mechanism had developed which, in some instances, resembled flutter of circus-movement origin. When aconitine-induced and circus-movement flutters were induced separately and simultaneously in auricles functionally divided by a crush, they responded to drugs in their characteristic manners. Aconitine-induced flutter slowed progressively and recovered gradually to flutter, whereas circus-movement flutter frequently reverted suddenly and permanently to sinus rhythm.
Dextro 3:5:3 ′ Triiodothyronine
Authors: David F. Brown
Journal: JAMA (1962)

Various analogues and isomers of levothyroxin have been shown to be considerably less calorigenic than the naturally occurring hormone, though they retain its lipid-lowering properties. The purpose of this study was to measure the effect of one of these isomers, dextro-triiodothyronine, on the serum lipid levels of 23 patients with ischemic heart disease and with cholesterol levels exceeding 300 mg.%. Cholesterol, triglycerides, and phospholipids were measured in all patients at intervals during the 40 weeks of this study. In doses of 1.5 to 2 mg. daily dextro-triiodothyronine was able to produce effective and prolonged reduction of all 3 lipids. In spite of the absence of evidence of hyperthyroidism in all patients receiving this drug, 8 of the 23 experienced increased severity or frequency of angina pectoris. The frequency and seriousness of this side effect precludes the general use of this drug in patients with ischemic heart disease, but additional analogues of this nature should be sought and studied.
Simvastatin Initiated Early After Heart Transplantation
Authors: Klaus Wenke, Bruno Meiser, Joachim Thiery, Dorothea Nagel, Wolfgang von Scheidt, Karl Krobot, Gerhard Steinbeck, Dietrich Seidel, Bruno Reichart
Journal: Circulation (2003)

Background— Randomized clinical trials have demonstrated that the use of statins in heart transplant patients lowers cholesterol levels and significantly reduces mortality and the development of transplant vasculopathy. The aim of the present study was to test these effects and the safety of statin therapy over an 8-year period. Methods and Results— In 1991, a prospective, randomized, unmasked study was initiated to compare the efficacy of simvastatin, started on the fourth postoperative day (n=35), with that of dietary therapy alone (n=37). Because of significantly improved survival and a lower incidence of transplant vasculopathy, most patients in both groups received statins as open-label prescriptions after 4 years. After 8 years, the Kaplan-Meier survival rate was 88.6% in the simvastatin group versus 59.5% in the control group ( P &lt;0.006 by log rank; hazard ratio, 0.24; 95% CI, 0.08 to 0.71). Deaths in the simvastatin and control groups were due to transplant vasculopathy (1 versus 4; P &lt;0.2), severe transplant rejection (1 versus 5; P &lt;0.1), malignancies (0 versus 3; P &lt;0.1), and other causes (2 versus 3; P &lt;0.7). The incidence of transplant vasculopathy confirmed by angiography was 24.4% in the simvastatin group versus 54.7% in the control group ( P &lt;0.02 by log rank). There was no difference in organ function between the 2 groups. No severe adverse effects of the therapy were observed up to the end of the 8-year observation period. Conclusions— Simvastatin therapy initiated early after heart transplantation leads to significantly better 8-year survival rates and a significantly lower incidence of transplant vasculopathy without impairment of organ function or severe adverse effects.
TNF-α (−308 G/A) and CD14 (−159T/C) polymorphisms in the bronchial responsiveness of Korean children with asthma
Authors: Soo-Jong Hong, Hyo-Bin Kim, Mi-Jin Kang, So-Yeon Lee, Ja-Hyung Kim, Bong-Seong Kim, Seong-Ok Jang, Hyung-Doo Shin, Choon-Sik Park
Journal: Journal of Allergy and Clinical Immunology (2006)
THE TEMPORARILY REINFORCED DRAINAGE TUBE
Authors: Emmet A. Printy
Journal: JAMA (1924)

Most surgeons have encountered, at one time or another, difficulty in suturing in place flexible rubber drainage tubes, when used for drainage of a hollow viscus. Some years ago I<sup>1</sup>described a method of reinforcing the tube, which presented many advantages. Originally, solid glass rods of various sizes were used to render the tube temporarily nonflexible. Since that time, metal rods of proper size have been made for this purpose by V. Mueller &amp; Co. After the surgeon determines what size of rubber drainage tube he will use, the nurse threads it over the proper rod. It will be found that a tube so prepared (5 in the accompanying illustration) is. easy to introduce and to hold in place. The insertion of fixation sutures is facilitated, and purse-string sutures can be tied firmly, without danger of occluding the lumen of the tube by compression. The inversion that precedes the
Patterns of Utilization in Partial Hospitalization
Authors: ALLAN BEIGEL, SAMUEL L. FEDER
Journal: American Journal of Psychiatry (1970)

A sample of 176 patients admitted to a day and night hospital was studied in an attempt to identify factors predictive of complete utilization of a partial hospitalization program and to relate these specifically to the way in which such programs are now used and might be planned for the future. The clinical state of the patient, in terms of acuteness or chronicity, was found to be a more useful predictor than other criteria commonly used. The authors conclude that separate programs are required for acute and chronic patients, reflecting differing emphases and patient needs.
DERMATOCONJUNCTIVITIS DUE TO LASH-LURE, AN EYELASH AND EYEBROW DYE
Authors: Sigmund S. Greenbaum
Journal: JAMA (1933)

This report on a case of dermatoconjunctivitis due to Lash-Lure, a new eyelash and eyebrow dye, is offered for record.  The dangerous possibilities of certain types of hair dye has, of course, been known to the medical profession and to dermatologists in particular for many years. The use of such dyes has, however, been restricted to the scalp hair. Extending their use to the eyelash field is new and a reaction as severe as that which occurred in this patient deserves more than the passing comment ordinarily given by dermatologists to the frequent cutaneous reactions to cosmetics observed by them.  Darkening of the eyebrows and eyelashes is accomplished in two ways: one by coating the hairs (Mascara, lamp-black) and the other by actually staining them. Intolerance of the conjunctiva and eyelids to Mascara is well known but rarely produces more than a very mild reaction—commonly only a pruritus or burning
B. PYOCYANEUS MENINGITIS WITH RECOVERY
Authors: J. F. D. Shrewsbury
Journal: BMJ (1934)

RECOVERY TME.BiTT .~~~~~quite distinct groups of physicians; these -show a very marked parallelism.The most obvious fact that emerges from this study is the strikingly constant and high "incidence of rheumatic heart disease among hospital patients.It thus serves to show, if any further evidence is needed, the urgent neces- sity for further study into the aetiology of acute rheum- atism and into methods for its prevention and relief.In view of the variations in the incidence of other types of heart disease, which are evident in this investigation, it would appear very desirable that such inquiries should be continued at different centres throughout Great Britain along similar lines for a longer period of time, so that it may be ascertained whether such variations are constant, and what local features are responsible for them.
Winds of change
Authors: M. A. Krousel-Wood
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhaled and Nasal Glucocorticoids and the Risks of Ocular Hypertension or Open-angle Glaucoma
Authors: Edeltraut Garbe
Journal: JAMA (1997)

To determine whether the use of inhaled and nasal glucocorticoids is associated with an increased risk of ocular hypertension or open-angle glaucoma.Case-control study.Québec universal health insurance program for all elderly (registered in the Régie de l'assurance maladie du Québec [RAMQ] database).Enrollees in the RAMQ database aged 66 years and older. The 9793 case patients were ophthalmology patients with a new diagnosis of borderline glaucoma or open-angle glaucoma or were newly started on treatment for ocular hypertension or glaucoma between 1988 and 1994. The 38,325 control patients were randomly selected among noncases with ophthalmologist visits in the same month and year as the case event (index date).The odds ratio (OR) of ocular hypertension or open-angle glaucoma was determined in patients using inhaled or nasal glucocorticoids relative to nonusers, using conditional logistic regression analysis. The OR was adjusted for age, sex, diabetes mellitus, systemic hypertension, use of ophthalmic and oral glucocorticoids, and characteristics of health care system use in the year before the index date.Overall, current use of inhaled and nasal glucocorticoids was not associated with an increased risk of ocular hypertension or open-angle glaucoma. Current users of high doses of inhaled steroids prescribed regularly for 3 or more months were at an increased risk with an OR of 1.44 (95% confidence interval, 1.01-2.06).Prolonged administration of high doses of inhaled glucocorticoids increases the risk of ocular hypertension or open-angle glaucoma. This finding suggests that in these patients intraocular pressure monitoring may be warranted.