Factor V Leiden and Venous Thromboembolism
Authors: Jan P. Vandenbroucke, Frits R. Rosendaal
Journal: Annals of Internal Medicine (2004)

Letters21 September 2004Factor V Leiden and Venous ThromboembolismJan P. Vandenbroucke, MD, PhD and Frits R. Rosendaal, MD, PhDJan P. Vandenbroucke, MD, PhDFrom Leiden University Medical Center, 2300 RC Leiden, the Netherlands.Search for more papers by this author and Frits R. Rosendaal, MD, PhDFrom Leiden University Medical Center, 2300 RC Leiden, the Netherlands.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-6-200409210-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Juul and colleagues (1) reported the results of the Copenhagen City Heart Study, a Danish cohort study that followed 9253 individuals beginning in 1976. They found that risk for VTE was increased 3-fold among carriers of factor V Leiden (216 events and 43 carriers) (1). This relative risk was substantially lower than the 7-fold risk that we reported in a case–control study of 474 patients with thrombosis and 474 controls (92 and 14 carriers, respectively) (2). Juul and colleagues ascribe this difference to “ascertainment bias” and a preponderance of risk factors among patients with venous thrombosis.This ...References1. Juul K, Tybjaerg-Hansen A, Schnohr P, Nordestgaard BG. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann Intern Med. 2004;140:330-7. [PMID: 14996674] LinkGoogle Scholar2. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood. 1995;85:1504-8. [PMID: 7888671] CrossrefMedlineGoogle Scholar3. Rosendaal FR. Bridging case–control studies and randomized trials. Curr Control Trials Cardiovasc Med. 2001;2:109-110. [PMID: 11806781] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Leiden University Medical Center, 2300 RC Leiden, the Netherlands. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFactor V Leiden and the Risk for Venous Thromboembolism in the Adult Danish Population Klaus Juul , Anne Tybjærg-Hansen , Peter Schnohr , and Børge G. Nordestgaard Factor V Leiden and Venous Thromboembolism Klaus Juul , Børge G. Nordestgaard , and Anne Tybjærg-Hansen Factor V Leiden and Venous Thromboembolism Philip T. Murphy Metrics Cited ByRacial differences in the prevalence of Factor V Leiden mutation among patients on chronic warfarin therapyFrequency of Thrombophilia-Related Genetic Variations in Patients with Idiopathic Pulmonary Embolism in an Urban Emergency Department 21 September 2004Volume 141, Issue 6Page: 484KeywordsCohort studiesFactor V LeidenMedical risk factorsOral contraceptive therapyProspective studiesPulmonary embolismRelative riskRisk managementThrombosisVenous thromboembolism ePublished: 21 September 2004 Issue Published: 21 September 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...