tbuckley/cabot-search huggingface dataset:
THE USE OF A MODIFIED THEMATIC APPERCEPTION TEST IN A NEUROPSYCHIATRIC CLINIC IN A GENERAL HOSPITAL
Authors: JACKSON A. SMITH, WARREN T. BROWN, FLORENCE L. THROWER
Journal: American Journal of Psychiatry (1951)

The Thematic Apperception Test has been used as a part of the routine workup of 25 patients seen in a psychiatric clinic in a general hospital. In these cases it appeared to be a definite aid in quickly gaining understanding of the patients' problems, and avoided emphasizing the somatic complaints. Also, the information helped the therapist in guiding the initial interview into more productive channels. The test was modified by getting responses to only 8 cards, which seemed to give the maximum information for the time spent. The previous finding of the particular value of the test in those individuals who verbalize poorly was re-affirmed in this study.
Foreign Medical Graduates
Authors: John H. Tanton
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The article by Bernard M. Weinstein, MPH, "The Foreign Medical Graduate Issue and US Hospitals: In Regard to Public Law 94-484" (241:917,1979), serves to highlight the chauvinism and short-term expediency that permeates US attitudes and laws governing immigration. In his concluding paragraph, he states that, in deciding whether foreign medical graduates (FMGs) should be admitted to fill vacancies in the US medical care system, "the bottom line is whether patients have a physician to attend to their needs." He refers, of course, to patients in the United States; what about patients in the country of the FMG's origin? Most of those countries have far fewer physicians per capita than does the United States and fewer resources with which to train health care workers. Weinstein goes on to state that restricting the entry of FMGs into the United States "would be both morally and politically weak." To the
Effect of Alteration of Serum Potassium on Ureteral Peristalsis
Authors: William Samellas, Harry H. LeVeen
Journal: JAMA (1964)

KNOWLEDGE OF ureteral peristalsis has been inadequate because of the low sensitivity of the recording instruments used. The organs under study are small, and conventional instrumentation distorts their function. Although urine is transported through the urinary tract by means of force produced by the peristaltic activity of the smooth muscles of the ureteral wall, the details of hydrodynamics have escaped scrutiny. Sensitive electronic strain gauges are now available to record phasic pressure fluctuations with minimal volume changes. These are used with small-caliber, nonobstructing catheters to avoid retention of urine which complicated previous methods used to record ureteral peristalsis. This development has given new impetus to the study of the physiology and pathophysiology of the upper urinary tract. Experiments with this equipment demonstrate that the activity of the normal ureter is remarkably independent of impulses of neuromuscular origin and it is not influenced by the administration of drugs. Because potassium has
Abnormalities of the Ascending Aorta Detected by Gated Blood Pool Imaging
Authors: MICHAEL H. SUSSMAN, STEVEN F. HOROWITZ, JOSE L. NAVARRO, JOSEF MACHAC
Journal: Clinical Nuclear Medicine (1986)

Radionuclide angiography has been used for visualization of aortic arch pathology. Gated blood pool scintigraphy generally has been reserved for the evaluation of ventricular function. By observing the aorta in relation to other cardiac structures, additional information about relative size and shape is available, and can be integrated with ventriculographic observations. This may enhance understanding of the mechanism of disease in the individual patient. Five selected case histories illustrating this point are presented. The last example demonstrates the ability of the technique to uncover unsuspected thoracic aorta pathologic findings. The sensitivity and specificity of this technique to diagnose aortic disease requires further study.
Long-term improvement in functional status, quality of life and exercise capacity with cardiac resynchronization therapy: the MIRACLE trial experience
Authors: William T. Abraham, Westby Fisher, Andrew Smith, David DeLurgio, Angel Leon, Evan Loh, Dusan Kocovic, Alfredo Clavell, David Hayes, Anthony Tang, Ven Manda, Susan Petersen-Stejskal
Journal: Journal of the American College of Cardiology (2002)
282 Diagnostic value of fibrosis biochemical markers (fibrotest) for the prediction of portal hypertension in chronic liver disease
Authors: D THABUT, D LEBREC, F IMBERTBISMUT, D CAZALSHATEM, R MOREAU, D MESSOUS, V RATZIU, M MUNTEANU, D VALLA, T POYNARD
Journal: Hepatology (2003)
Classifying Acute Leukemias
Authors: KONG-OO GOH
Journal: Annals of Internal Medicine (1972)

Editorial Notes1 February 1972Classifying Acute LeukemiasKONG-OO GOH, M.D.KONG-OO GOH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-2-325 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe conventional classification of leukemias is based on the morphological cell lines (myelocytic, lymphocytic, monocytic) and the clinical course of the disease (acute or chronic). Greater precision has been added recently to diagnosis of certain leukemias by use of cytogenetic techniques. There is a close relation between the acuteness of the disease and the involvement of the immature cell types. The morphologic division is rarely sharp; mixed components are frequently seen. Most of the leukemias maintain the original cell line during recurrence of the disease after a remission. In some cases, however, different stem cells or younger cells become involved,...References1. MATHÉPOUILLARTSTERESCU GPM: Subdivision of classical varieties of acute leukemia: correlation with prognosis and cure expectancy. Rev Eur Etud Clin Biol 16:554-560, 1971 MedlineGoogle Scholar2. HARTTRUJILLOFREIREICH JJE: Cytogenetic studies and their clinical correlates in adults with acute leukemia. Ann Intern Med 75:353-360, 1971 LinkGoogle Scholar3. CANELLOSDEVITAWHANG-PENG GVJ: Hematologic and cytogenetic remission of blastic transformation in chronic granulocytic leukemia: effect of vincristine and prednisone. 7th Annual Scientific Meeting of the American Society for Clinical Oncology, 7 April 1971, Chicago, Ill. Google Scholar4. REISMANMITANIZUELZER LMW: Chromosome studies in leukemia. N Engl J Med 270:591-597, 1964 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Monroe Community Hospital and the University of Rochester School of Medicine and Dentistry Rochester, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1972Volume 76, Issue 2Page: 325-326KeywordsCytogeneticsLeukemiaStem cell linesStem cells ePublished: 1 December 2008 Issue Published: 1 February 1972 PDF downloadLoading ...
Identification and characterization of agonist epitopes of the MUC1-C oncoprotein
Authors: Caroline Jochems, Jo A Tucker, Matteo Vergati, Benjamin Boyerinas, James L Gulley, Jeffrey Schlom, Kwong-Yok Tsang
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts The MUC1 tumor-associated antigen is overexpressed in the majority of human carcinomas and several hematologic malignancies. Much attention has been paid to the hypoglycosylated VNTR region of the N-terminus of MUC1 as a vaccine target, and recombinant viral vector vaccines are
Localized amyloidosis of the lower respiratory tract
Authors: A. R. Mainwaring, G. Williams, E. O. W. Knight, H. F. M. Bassett
Journal: Thorax (1969)

The clinical and pathological findings in a case of amyloidosis localized to the lower respiratory tract are described. We think this is the first report of a female patient with multiple deposits limited to the bronchial tree. The vascular areas in some amyloid deposits were considered to be secondary to pre-existing infection. The fine structure of the amyloid conforms to that of amyloid at other sites in man and in experimental animals.
Recombinant Glucagon-Like Peptide-1 Increases Myocardial Glucose Uptake and Improves Left Ventricular Performance in Conscious Dogs With Pacing-Induced Dilated Cardiomyopathy
Authors: Lazaros A. Nikolaidis, Dariush Elahi, Teresa Hentosz, Aaron Doverspike, Rhonda Huerbin, Lee Zourelias, Carol Stolarski, You-tang Shen, Richard P. Shannon
Journal: Circulation (2004)

The failing heart demonstrates a preference for glucose as its metabolic substrate. Whether enhancing myocardial glucose uptake favorably influences left ventricular (LV) contractile performance in heart failure remains uncertain. Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with potent insulinotropic effects the action of which is attenuated when glucose levels fall below 4 mmol. We examined the impact of recombinant GLP-1 (rGLP-1) on LV and systemic hemodynamics and myocardial substrate uptake in conscious dogs with advanced dilated cardiomyopathy (DCM) as a mechanism for overcoming myocardial insulin resistance and enhancing myocardial glucose uptake.Thirty-five dogs were instrumented and studied in the fully conscious state. Advanced DCM was induced by 28 days of rapid pacing. Sixteen dogs with advanced DCM received a 48-hour infusion of rGLP-1 (1.5 pmol x kg(-1) x min(-1)). Eight dogs with DCM served as controls and received 48 hours of a saline infusion (3 mL/d). Infusion of rGLP-1 was associated with significant (P<0.02) increases in LV dP/dt (98%), stroke volume (102%), and cardiac output (57%) and significant decreases in LV end-diastolic pressure, heart rate, and systemic vascular resistance. rGLP-1 increased myocardial insulin sensitivity and myocardial glucose uptake. There were no significant changes in the saline control group.rGLP-1 dramatically improved LV and systemic hemodynamics in conscious dogs with advanced DCM induced by rapid pacing. rGLP-1 has insulinomimetic and glucagonostatic properties, with resultant increases in myocardial glucose uptake. rGLP-1 may be a useful metabolic adjuvant in decompensated heart failure.
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function
Authors: Sebastian Zeissig, Stephanie K. Dougan, Duarte C. Barral, Yvonne Junker, Zhangguo Chen, Arthur Kaser, Madelyn Ho, Hannah Mandel, Adam McIntyre, Susan M. Kennedy, Gavin F. Painter, Natacha Veerapen, Gurdyal S. Besra, Vincenzo Cerundolo, Simon Yue, Sarah Beladi, Samuel M. Behar, Xiuxu Chen, Jenny E. Gumperz, Karine Breckpot, Anna Raper, Amanda Baer, Mark A. Exley, Robert A. Hegele, Marina Cuchel, Daniel J. Rader, Nicholas O. Davidson, Richard S. Blumberg
Journal: Journal of Clinical Investigation (2010)

Abetalipoproteinemia (ABL) is a rare Mendelian disorder of lipid metabolism due to genetic deficiency in microsomal triglyceride transfer protein (MTP). It is associated with defects in MTP-mediated lipid transfer onto apolipoprotein B (APOB) and impaired secretion of APOB-containing lipoproteins. Recently, MTP was shown to regulate the CD1 family of lipid antigen-presenting molecules, but little is known about immune function in ABL patients. Here, we have shown that ABL is characterized by immune defects affecting presentation of self and microbial lipid antigens by group 1 (CD1a, CD1b, CD1c) and group 2 (CD1d) CD1 molecules. In dendritic cells isolated from ABL patients, MTP deficiency was associated with increased proteasomal degradation of group 1 CD1 molecules. Although CD1d escaped degradation, it was unable to load antigens and exhibited functional defects similar to those affecting the group 1 CD1 molecules. The reduction in CD1 function resulted in impaired activation of CD1-restricted T and invariant natural killer T (iNKT) cells and reduced numbers and phenotypic alterations of iNKT cells consistent with central and peripheral CD1 defects in vivo. These data highlight MTP as a unique regulator of human metabolic and immune pathways and reveal that ABL is not only a disorder of lipid metabolism but also an immune disease involving CD1.
AN UNUSUAL CASE OF NASAL SYPHILIS IN A CHILD AND A CONSIDERATION OF SYPHILITIC NASAL TUMORS (SYPHILOMATA.)
Authors: CLEMENT F. THEISEN
Journal: JAMA (1903)

The consideration of syphilitic affections of the nose has always been of such interest that another paper on the same subject needs no apology, even though no new ideas can be advanced. Syphilitic conditions involving the nose at times take on very unusual forms, and very often do not in the slightest degree follow the classical picture described in the text-books. This is particularly true of late tertiary lesions. Tertiary manifestations, such as broken-down gummata, destructive ulcerative processes and caries followed by the well-known deformities, are, of course, very common, and are usually easily recognized. This is not so, however, when the tertiary lesion takes the form of a tumor—a syphiloma—particularly when no history of syphilis can be obtained. This form of the disease will be the only one considered in this paper. A considerable number of cases of tertiary nasal syphilis have come under the writer's
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase–dependent induction of Socs-3
Authors: Roberta Caruso, Carmine Stolfi, Massimiliano Sarra, Angelamaria Rizzo, Massimo C. Fantini, Francesco Pallone, Thomas T. MacDonald, Giovanni Monteleone
Journal: Blood (2009)
The physiological position of the liver in the circulation is not a major determinant of its functional capacity
Authors: Gerry T. M. Wagenaar, Robert A. F. M. Chamuleau, Martinus A. W. Maas, Kora De Bruin, Hans A. M. Korfage, Wouter H. Lamers
Journal: Hepatology (1994)

The zonal patterns of gene expression in the liver of the rat are not affected by alteration of the afferent hepatic blood source. We investigated whether afferent hepatic blood source or flow rate affects the metabolic capacity of the liver. Using microsurgical techniques, we changed the afferent hepatic blood source to solely arterial blood, solely portal blood or solely caval blood. The transhepatic flow rate was four times higher in arterialized than in cavalized livers. Liver function was tested 2 wk after surgery. Three liver functions were tested (elimination of hepatic iminodiacetic acid from the liver and elimination of galactose and ammoniumbicarbonate from the circulation). Our results show that the afferent hepatic blood flow rate rather than the source of the afferent hepatic blood affects the elimination of the substrates tested. We found that at the physiological flow rate of approximately 15 ml/min and beyond, metabolic function does not depend on the flow of the afferent hepatic blood but that at lower flow rates the flow becomes a major determinant of the metabolic function of the liver. We conclude that the position of the liver within the circulation (i.e. between the gastrointestinal tract and the systemic circulation) is apparently not a prerequisite for adequate metabolic activity, at least for the substrates tested, provided that the liver is sufficiently perfused with blood. (Hepatology 1994;20:1532-1540).
Cardiac epinephrine synthesis. Regulation by a glucocorticoid.
Authors: B Kennedy, M G Ziegler
Journal: Circulation (1991)

BACKGROUND The heart can synthesize epinephrine. Homogenates of rat heart, which contain the enzymes phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase (NMT), methylate norepinephrine to form epinephrine. The cardiac atrium contains primarily PNMT and the cardiac ventricle contains both PNMT and NMT. METHODS AND RESULTS Rats were given the glucocorticoid dexamethasone at doses ranging from 0.2 to 20 mg/kg. Twenty-four hours later, cardiac atria, ventricle, skeletal muscle, and adrenal had increases in PNMT activity to as much as 230% of baseline. NMT activity was unchanged. Longer-term treatment with 1 mg/kg dexamethasone daily for 12 days increased cardiac PNMT activity about fivefold and also increased atrial epinephrine levels. Dexamethasone did not alter ventricular epinephrine levels but increased levels of both PNMT and catechol-O-methyltransferase, the major catabolic enzyme for epinephrine. After dexamethasone treatment, greater volumes of anti-PNMT antiserum were needed to decrease PNMT enzymatic activity, indicating that dexamethasone treatment resulted in greater amounts of PNMT and did not just activate existing PNMT molecules. Denervation of the masseter muscle of rats by unilateral superior cervical ganglionectomy markedly diminished tissue norepinephrine and epinephrine levels but had no effect on masseter PNMT or NMT levels. We have previously shown that chemical sympathectomy with 6-hydroxydopamine increases cardiac PNMT levels. These findings suggest that PNMT is an extraneuronal enzyme in both cardiac and skeletal muscle. CONCLUSIONS Glucocorticoids have several cardiovascular effects, including increased cardiac output and blood pressure. Enhanced cardiac epinephrine synthesis may mediate some of these glucocorticoid effects.
Medical Genetics 1958-1960
Authors: William B. Bean
Journal: JAMA (1962)

For several years, Victor McKusick has published annually a scholarly summary of medical genetics in the<i>Journal of Chronic Diseases</i>. Now he has put 3 of these summaries together in book form. Not only has the author achieved distinction in other fields of medical investigation such as spectrophonocardiography, but, employing his inquisitive mind and critical nature, he has availed himself of the splendid opportunities for collecting large masses of material, thus adding appreciably to our understanding of connective tissue diseases. Here he has summarized recent contributions to the field of medical genetics. Because this field is growing so rapidly, its current state cannot be put into a textbook fast enough—by the time such a text were written and printed, it would be out of date; a scholarly, critically annotated bibliography with much new information has to serve instead.<i>Medical Genetics 1958-1960</i>is an admirable source book and a necessary reference
Observations Suggested by the Study of Cases of Cataract Extraction
Authors: C. Taylor
Journal: BMJ (1868)

THE BRITISH MEEDICAL 7OURNA.569 3.That the natural secretions of glands in syphilitic subjects, when those glands are not themselves specifically diseased, have no power of imparting constitutional syphilis.After the reading of the above paper, Mr. PAGET, the President of the Surgical Section, at which Mr. Lee's paper was read at Oxford, stated that the paper appeared to him to afford a fair explanation of those cases in which secondary syphilitic symptoms have followed, and have appeared to be the consequences of soft chancres; such cases had occurred to most surgeons, and yet so rarely in comparison with those in which secondary symptoms followed hard sores, that they seemed insufficient to disprove the law according to which hard chancre, or diseases de- rived from it, are the necessary precedents of secondary symptoms, the sole sources of constitutional infection.A law of this kind, if there be one, can have no exceptions.What seem to be such must, if the law exists, be erroneously or incompletely observed facts.And here the in- completeness of the observations in some of the assumed exceptions may have been, as Mr. Lee suggested, that a patient had had a soft chancre at or about the same time as he had been infected from a hard sore, the virus of which had traversed sound textures, and had produced in them too little changc to be observed.It must have occurred to
Acid-Reducing Agents in Infants and Children
Authors: Alexandra N. Menchise, Mitchell B. Cohen
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Prediction of progressive joint damage in patients with rheumatoid arthritis receiving gold or D-penicillamine therapy.
Authors: P T Dawes, P D Fowler, R Jackson, M Collins, M F Shadforth, R Stone, D L Scott
Journal: Annals of the Rheumatic Diseases (1986)

Seventy two patients with classical or definite rheumatoid arthritis (RA) were randomly allocated to receive gold or D-penicillamine therapy (DPA) in a prospective study designed to evaluate whether it is possible to predict which patients will show radiological progression despite therapy. Forty five patients completed 12 months9 treatment. There were no significant demographic or clinical differences between them and the 27 drop outs. Twenty of the 45 patients showed no radiological progression between six and 12 months. These patients had less severe initial radiological damage, lower levels of serum aspartate transaminase (serum AST) and lactic dehydrogenase (LDH), but higher levels of serum cholesterol. Twenty five patients did show progression during the six to 12 month period. This group included all the men with nodules. Of the 43 pretreatment clinical and laboratory variables examined, however, the majority failed to predict whether or not progression would subsequently occur. This included the acute phase response and seropositivity.
Commercialisation is bad for public health
Authors: D. McCoy
Journal: BMJ (2012)

The Health and Social Care Bill 2011 is yet to be passed into legislation, but the NHS is already going through a process of considerable transformation. Such is the scale of change that I’m reminded of the time I spent working in the new, democratic South Africa.

The health system of the apartheid regime was abominable. Structurally, the public sector was a fractured mess, divided into multiple departments according to three races and 10 so called tribal homelands. A vast and unregulated network of private providers and insurance schemes added a further layer of fragmentation.

The South African health system was also deeply iniquitous, with world class medical care for an elite minority and a rudimentary service for the majority poor black population. Less well recognised was its inefficiency: a huge oversupply of medical care, overpriced medicines, and more money spent on the healthy than on the sick.

The drivers for this inequity and inefficiency were not just racism and organisational chaos, but also commercialisation and the profiteering and erosion of professional ethics that it spawns. Many within the health system were virtually printing money; shamelessly exploiting both patients and the public purse.

When offered a job that would …