Vinblastine-Loaded Platelets for Autoimmune Hemolytic Anemia
Authors: Morie A. Gertz, Robert M. Petitt, Alvaro A. Pineda, Mark R. Wick, Edwin A. Burgstaler
Journal: Annals of Internal Medicine (1981)

Brief Reports1 September 1981Vinblastine-Loaded Platelets for Autoimmune Hemolytic AnemiaMORIE A. GERTZ, M.D., ROBERT M. PETITT, M.D., ALVARO A. PINEDA, M.D., MARK R. WICK, M.D., EDWIN A. BURGSTALERMORIE A. GERTZ, M.D.Search for more papers by this author, ROBERT M. PETITT, M.D.Search for more papers by this author, ALVARO A. PINEDA, M.D.Search for more papers by this author, MARK R. WICK, M.D.Search for more papers by this author, EDWIN A. BURGSTALERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-3-325 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTreatment of autoimmune hemolytic anemia with corticosteroids (1), splenectomy (2), immune suppression (3), and plasma exchange (4), serially or in combination, often yields partial or short remissions. We describe a patient in whom refractory autoimmune hemolytic anemia was moderated by selective impairment of the mononuclear-phagocyte system. The success of this approach, initially proposed for treatment of immune thrombocytopenic purpura (5), suggests that erythrocytes and platelets share a common site of immune destruction and that the rate of this destruction is determined by the phagocyte.A 42-year-old housewife noted symptoms of anemia in August 1977 (see Figure 1). Hemoglobin was 7...References1. MURPHY S and LOBUGLIO A. Drug therapy of autoimmune hemolytic anemia. Semin Hematol. 1976;13:323-34. MedlineGoogle Scholar2. PIROFSKY B. Immune haemolytic disease: the auto-immune haemolytic anemias. Clin Haematol. 1975;4:167-80. CrossrefMedlineGoogle Scholar3. SKINNER M and SCHWARTZ R. Immunosuppressive therapy. N Engl J Med. 1972;287:221-7. CrossrefMedlineGoogle Scholar4. BRANDA R, MOLDOW C, MCCULLOUGH J, and JACOB H. Plasma exchange in the treatment of immune disease. Transfusion. 1975;15:570-6. CrossrefMedlineGoogle Scholar5. AHN Y, BYRNES J, and HARRINGTON W. The treatment of idiopathic thrombocytopenia with vinblastine-loaded platelets. N Engl J Med. 1978;298:1101-7. CrossrefMedlineGoogle Scholar6. ROSENFIELD R and JAGATHAMBAL . Transfusion therapy for autoimmune hemolytic anemia. Semin Hematol. 1976;13:311-21. MedlineGoogle Scholar7. ASTER R and ENRIGHT S. A platelet and granulocyte membrane defect in paroxysmal nocturnal hemoglobinuria: usefulness for the detection of platelet antibodies. Clin Invest. 1969;48:1199-210. CrossrefGoogle Scholar8. KAY N and DOUGLAS S. Monocyte-erythrocyte interaction in vitro in immune hemolytic anemias. Blood. 1977;50:889-97. CrossrefMedlineGoogle Scholar9. RODGERS G and RIES C. Refractory idiopathic thrombocytopenic purpura. Ann Intern Med. 1980;92:713-4. LinkGoogle Scholar10. AHN Y, BYRNES J, BRUNSKILL D, MORITZ J, and HARRINGTON W. Selective injury to macrophages: a new treatment for idiopathic autoimmune hemolytic anemia. Clin Res. 1978;26:340A. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MORIE A. GERTZ, M.D.; ROBERT M. PETITT, M.D.; ALVARO A. PINEDA, M.D.; MARK R. WICK, M.D.; EDWIN A. BURGSTALERAffiliations: Mayo Clinic and Mayo Foundation Rochester, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVincristine-loaded platelet infusion for treatment of refractory autoimmune hemolytic anemia and chronic immune thrombocytopenia: Rethinking old curesManagement of Autoimmune Hemolytic AnemiasAutoimmune hemolytic anemiaWeakness and Dyspnea in a Man with Hemolytic AnemiaGM-CSF and Accelerated Hemolysis[31] Use of platelets as drug carriers for the treatment of hematologic diseasesHigh-dose intravenous intact IgG infusion in refractory autoimmune hemolytic anemia (Evans syndrome)Immune Hemolytic Anemia in the AgedAutoimmune hemolysis: a critical reviewVinca-Loaded PlateletsAcute nonlymphocytic leukemia complicated by severe cytophagocytosis of formed blood elements by nonmalignant histiocytes: Cause of significant clinical morbidityVinblastine for Autoimmune Hemolytic AnemiaPAMELA L. MEDELLIN, M.D., ETHEL PATTEN, M.D., GARY B. WEISS, M.D., PH.D. 1 September 1981Volume 95, Issue 3Page: 325-326KeywordsAnemiaBlood plasmaHemoglobinHemolytic anemiaIdiopathic thrombocytopenic purpuraImmune suppressionPhagocytesPlateletsSplenectomy ePublished: 1 December 2008 Issue Published: 1 September 1981 PDF downloadLoading ...