Experiences with Cephalothin
Authors: ROBERT L. PERKINS
Journal: Annals of Internal Medicine (1966)

Article1 January 1966Experiences with CephalothinROBERT L. PERKINS, M.D., SAMUEL SASLAW, M.D., PH.D., F.A.C.P.ROBERT L. PERKINS, M.D.Search for more papers by this author, SAMUEL SASLAW, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-13 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCephalothin sodium is a semisynthetic derivative of cephalosporanic acid. The nucleus consists of fused beta-lactam and dihydrothiazine rings, thus resembling the penicillin nucleus (Figure 1). The wide antibacterial spectrum (1), penicillinase resistance (2), and apparent low toxicity (3, 4) of cephalothin present unusual advantages to the clinician. It is the purpose of this report to describe the response of 51 patients to treatment with cephalothin. In addition, studies are described in reference to comparative allergy testing with penicillin in 30 penicillin-allergic patients and to serial serum levels of cephalothin in normal volunteers.MATERIALS AND METHODSFifty of the patients were...References1. GRIFFITHBLACK RSHR: Cephalothin—a new antibiotic. Preliminary clinical and laboratory studies. JAMA 189: 823, 1964. CrossrefMedlineGoogle Scholar2. GODZESKIBRIERPAVEY CWGDE: Cephalothin, a new cephalosporin with a broad antibacterial spectrum. I. In vitro studies employing the gradient plate technique. Appl. Microbiol. 11: 122, 1963. CrossrefMedlineGoogle Scholar3. LEEHERRANDERSON CCEBRC: Pharmacological and toxicological studies on cephalothin. Clin. Med. 70: 1123, 1963. Google Scholar4. SIDELLBURDICKBRODLEBULGERKIRBY SREJRJWM: New antistaphylococcal antibiotics. Comparative in vitro and in vivo activity of cephalothin, nafcillin, cloxacillin, oxacillin, and methicillin. Arch. Intern. Med. (Chicago) 112: 21, 1963. 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CrossrefMedlineGoogle Scholar11. CHANGWEINSTEIN TWL: Isolation, characterization, and distribution of cephalosporinase, in Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann Arbor, Mich., 1963, p. 278. Google Scholar12. WALTERSROMANSKYJOHNSON EWMJAC: Cephalothin—laboratory and clinical studies in 109 patients. Ibid., p. 247. Google Scholar13. PHILSONCLANCYALEXANDER JRCFJD: Cephalothin therapy in bacterial infections. Ibid., p. 267. Google Scholar14. FLUXRILEYBRACKEN MHDEC: Treatment of 100 infants and children with cephalothin. Ibid., p. 254. Google Scholar15. KIRBY WM: Clinical status of cephalothin, in Antimicrobial Agents and Chemotherapy. Braun-Brumfield, Ann Arbor, Mich., 1964, p. 274. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT L. PERKINS, M.D.; SAMUEL SASLAW, M.D., PH.D., F.A.C.P.Affiliations: Columbus, OhioFrom the Department of Medicine, Ohio State University, Columbus, Ohio.Portions of this study were presented at the regional meeting of the American College of Physicians, January 22, 1965, Cincinnati, Ohio.Requests for reprints should be addressed to Robert L. Perkins, M.D., University Hospital, Ohio State University, Columbus, Ohio 43210. 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Antibiotics and Related CompoundsTreatment of Bacterial Endocarditis with Cephalosporin Derivatives in Penicillin-Allergic Patients 1 January 1966Volume 64, Issue 1Page: 13-24KeywordsAllergy and immunologyOutpatientsPenicillinResearch designSkin testsSodiumStaphylococcal infectionStreptococcal infectionsToxicity ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...