Fruit and Vegetable Intake and Coronary Heart Disease
Authors: Alexandra Alves-Rodrigues, Boban Thomas
Journal: Annals of Internal Medicine (2002)

Letters16 July 2002Fruit and Vegetable Intake and Coronary Heart DiseaseAlexandra Alves-Rodrigues, PhD and Boban Thomas, MDAlexandra Alves-Rodrigues, PhDHospital Fernando Fonseca; Amadora 2700, Portugal (Alves-Rodrigues, Thomas)Search for more papers by this author and Boban Thomas, MDHospital Fernando Fonseca; Amadora 2700, Portugal (Alves-Rodrigues, Thomas)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-2-200207160-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Joshipura and colleagues (1) presented epidemiologic evidence suggesting that consumption of green leafy vegetables and vitamin C–rich fruits and vegetables protects against coronary artery disease. The cardioprotective effect of green leafy vegetables may be due to high levels of the antioxidant lutein. In a recent experiment using epidemiologic data, an in vitro model, and a mouse model, Dwyer and coworkers (2) showed that lutein, a carotenoid with no pro–vitamin A activity, protected against progression of arteriosclerosis. Lutein achieved this effect by lowering very low-density lipoprotein and intermediate-density lipoprotein levels via pathways that reduced inflammation and oxidative stress ...References1. Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, et al . The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med. 2001;134:1106-14. [PMID: 11412050] LinkGoogle Scholar2. Dwyer JH, Navab M, Dwyer KM, Hassan K, Sun P, Shircore A, et al . Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atheroscle-rosis study. Circulation. 2001;103:2922-7. [PMID: 11413081] CrossrefMedlineGoogle Scholar3. Howard AN, Williams NR, Palmer CR, Cambou JP, Evans AE, Foote JW, et al . Do hydroxy-carotenoids prevent coronary heart disease? A comparison between Belfast and Toulouse. Int J Vitam Nutr Res. 1996;66:113-8. [PMID: 8843985] MedlineGoogle Scholar4. Landrum JT, Bone RA. Lutein, zeaxanthin, and the macular pigment. Arch Bio-chem Biophys. 2001;385:28-40. [PMID: 11361022] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Alexandra Alves-Rodrigues, PhD; Boban Thomas, MDAffiliations: Hospital Fernando Fonseca; Amadora 2700, Portugal (Alves-Rodrigues, Thomas) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease Kaumudi J. Joshipura , Frank B. Hu , JoAnn E. Manson , Meir J. Stampfer , Eric B. Rimm , Frank E. Speizer , Graham Colditz , Alberto Ascherio , Bernard Rosner , Donna Spiegelman , and Walter C. Willett Fruit and Vegetable Intake and Coronary Heart Disease Peter Lindenauer , Darius A. Rastegar , and Dorothea von Goeler Fruit and Vegetable Intake and Coronary Heart Disease Kaumudi J. Joshipura , Frank B. Hu , and Walter C. Willett Metrics Cited byDietary intake as a cardiovascular risk factor: a cross-sectional study of bank employees in AccraThe science behind lutein 16 July 2002Volume 137, Issue 2Page: 143-144KeywordsAttentionBlood plasmaCarotenoidsEpidemiologyMacular degenerationMouse modelsOxidative stressPopulation statisticsStable coronary artery diseaseVery low density lipoprotein ePublished: 16 July 2002 Issue Published: 16 July 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...