tbuckley/cabot-search huggingface dataset:
Abstract LB-368: III-tubulin knockdown in endothelial cells increases the antivascular activity of chemotherapeutic drugs
Authors: Eddy Pasquier, Snega Sinnappan, Pascal Verdier-Pinard, Diane Braguer, Maria Kavallaris
Journal: Cancer Research (2010)

Abstract The microtubule cytoskeleton plays a crucial role in tumor angiogenesis, as evidenced by the potent anti-vascular properties of microtubule-targeting anticancer agents (MTAs). Accumulating evidence shows that the expression level of β-tubulin isotypes influences drug response and βIII-tubulin in particular has been involved in cancer cell resistance to MTAs as well as other classes of chemotherapeutic agents (1). However, the role of β-tubulin isotypes in the context of tumor angiogenesis and anti-vascular therapy remains unknown. Comparative western blot analysis revealed that human vascular endothelial cells express relatively high levels of βII- and βIII-tubulin. Using siRNA gene silencing, we effectively suppressed the expression levels of βII-and βIII-tubulin isotypes in vascular endothelial cells, by 90% and 80%, respectively. Functional analysis showed that βII-tubulin expression did not significantly influence either the capacity of endothelial cells to form vascular structures on Matrigel or the anti-vascular properties of MTAs. In contrast, knocking down the expression of βIII-tubulin in endothelial cells significantly inhibited the formation of capillary-like structures on Matrigel by 18 ± 3 % (p&amp;lt;0.001). Furthermore, the anti-angiogenic activity of the microtubule-stabilizing agent, paclitaxel, and the microtubule-depolymerizing agents, vinblastine and 2-methoxyestradiol (2-ME2), was significantly increased between 1.6 and 2.5-fold (p&amp;lt;0.05) in βIII-tubulin knockdown endothelial cells, as compared to control siRNA and βII-tubulin knockdown cells. Similarly, the vascular-disrupting activity of ENMD-1198, a new analog of 2-ME2, was also increased by 2.2-fold (p&amp;lt;0.05) in βIII-tubulin knockdown endothelial cells. More broadly, βIII-tubulin knockdown in endothelial cells also increased the anti-angiogenic activity of other classes of chemotherapeutic drugs, such as topoisomerase inhibitor etoposide (18 ± 1%, p&amp;lt;0.01) and alkylating agent cyclophosphamide (35 ± 5%, p&amp;lt;0.05). Altogether these results strongly suggest that βIII-tubulin may play a role in tumor angiogenesis and influence the anti-vascular activity of chemotherapeutic drugs. Further investigations are currently underway to unravel the underlying mechanisms. References 1. Gan P., Pasquier E. and Kavallaris M. Class III beta-tubulin mediates sensitivity to chemotherapeutic drugs in non-small cell lung cancer. Cancer Res. 2007, 67: 9356-9363. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-368.
An indolent type of Epstein-Barr virus-associated T-cell-rich B-cell lymphoma of the skin: Report of a case
Authors: Hitoshi Take, Kazuo Kubota, Toshio Fukuda, Shogo Shinonome, Osamu Ishikawa, Takuo Shirakura
Journal: American Journal of Hematology (1996)

A 74-year-old Japanese man presented with systemic lymphadenopathy, hepatosplenomegaly, and erythroderma in December 1991.A characteristic pattern of anti-EBV antibodies was suggestive of latent EBV infection.A skin tumor biopsied in April 1993 contained biclonal EBV genomes diffusely in the infiltrate of polyclonal T cells and monoclonal B cells.The clinical course was rather mild in contrast to that of classical EBV-associated disorders.Our case was considered a rare indolent type of EBV-associated T-cell-rich Bcell lymphoma of the skin.
Variation in patients' perceptions of elective percutaneous coronary intervention in stable coronary artery disease: cross sectional study
Authors: F. Kureshi, P. G. Jones, D. M. Buchanan, M. S. Abdallah, J. A. Spertus
Journal: BMJ (2014)

To determine the incidence, prevalence, and outcome of systemic lupus erythematosus (SLE) in a well delineated black population in the Caribbean basin data were collected on the disease course of all patients with definite SLE seen during a 10 year period (1980-9) using three different sources of information (hospital records, private practice records, and death certificates). Ninety four patients were identified giving an average annual incidence rate of 4.6/100,000 (95% confidence interval (CI) 0.4 to 8.8), which showed little variation during the study period. Twenty five patients (27%) died during the study period, giving a point prevalence of 47/100,000 (CI 34.1 to 51.1) in 1990. In women aged 15-44 years the annual incidence (12/100,000; CI 5.3 to 18.9) was highest, whereas in women aged 44-65 years the 1990 point prevalence rate (one in 526; CI 469 to 625) was highest. Annual mortality was 1.7/100,000 (CI -0.8 to 4.2) with a female to male ratio of 5.3. Renal disease was the most common complication, occurring in 73 (78%) patients. Thus the transatlantic movement from an area with a (presumably) low prevalence of SLE (Central Africa) has been accompanied by an increase in the prevalence of SLE in the black population of Curaçao, indicating that environmental factors may prevail over genetic factors in the expression of this disease.
A History Lesson
Authors: Lindley A. Barbee, Robert M. Centor, Zachary D. Goldberger, Sanjay Saint, Shireesha Dhanireddy
Journal: New England Journal of Medicine (2015)

A 34-year-old man presented to an ambulatory care center with a 3-day history of a sore throat. He reported associated subjective fevers, chills, sinus pressure, occasional coughing, and fatigue but no dyspnea, headache, or abdominal pain.
Effect of Cortisone on the Size of Experimentally Produced Myocardial Infarcts
Authors: ARAN S. JOHNSON, SCHAYEL R. SCHEINBERG, ROBERT A. GERISCH, HARRY C. SALTZSTEIN
Journal: Circulation (1953)

In a total of 57 dogs the anterior descending branch of the left coronary artery was doubly ligated. Cortisone apparently (1) reduced the area of residual fibrosis; (2) increased the vascularity of the heart.
Surfactant Secretion and Respiratory Distress Syndromes
Authors: DONALD F. TIERNEY
Journal: Annals of Internal Medicine (1972)

Editorial Notes1 October 1972Surfactant Secretion and Respiratory Distress SyndromesDONALD F. TIERNEY, M.D.DONALD F. TIERNEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-652 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptControl of secretion from many organs has interested clinicians and physiologists for more than a half century, but only recently has attention been directed to control of one of the most essential secretions, the pulmonary surfactant. The lung is rarely considered when secretory organs are discussed, but the exocrine secretion of surfactant onto the alveolar surface is vital, and inadequate secretion of surfactant will produce the respiratory distress syndromes in adults or infants. The secretory cells for surfactant appear to be the type II cells (1, 2) that constitute part of the alveolar epithelial lining and that number about 2%...References1. KLAUS M, REISS O, and TOOLEY W: Alveolar epithelial cell mitochondria as source of the surface-active lung lining. Science 137:750-751, 1962 CrossrefMedlineGoogle Scholar2. ASKIN F and KUHN C: The cellular origin of pulmonary surfactant. Lab Invest 25:260-268, 1971 MedlineGoogle Scholar3. LIGGINS G: Premature delivery of foetal lambs infused with glucocorticoids. J Endocrinol 45:515-523, 1969 CrossrefMedlineGoogle Scholar4. DELEMOS R, SHERMETA D, and KNELSON J: Acceleration of appearance of pulmonary surfactant in the fetal lamb by administration of corticosteriods. Am Rev Resp Dis 102:459-461, 1970 MedlineGoogle Scholar5. WANG N, KOTAS R, and AVERY M: Accelerated appearance of osmiophilic bodies in fetal lungs following steroid injection. J Appl Physiol 30:362-365, 1971 CrossrefMedlineGoogle Scholar6. TIERNEY D and JOHNSON R: Altered surface tension of lung extracts and lung mechanics. J Appl Physiol 20:1253-1260, 1965 CrossrefGoogle Scholar7. REDDING R, DOUGLAS W, and STEIN M: Thyroid hormone influence upon lung surfactant metabolism. Science 175:994-996, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD F. TIERNEY, M.D.Affiliations: Department of Medicine Harbor General Hospital Torrance, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRapidly Progressive Lymphoma of the Lung Appearing as the Adult Respiratory Distress SyndromeRecognition and treatment of adult respiratory distress syndrome secondary to viral interstitial pneumonia 1 October 1972Volume 77, Issue 4Page: 652-653KeywordsCellsInfantsLungsRespiratory distress syndromeRespiratory physiologyVentilators ePublished: 1 December 2008 Issue Published: 1 October 1972 PDF downloadLoading ...
The Medical School Experience
Authors: Michael R. Moore
Journal: JAMA (1981)

To the Editor.—  David J. Bressler provides some interesting and accurate insights into the contemporary medical school experience in his COMMENTARY Notes From Overground: Fourth Year at Harvard Medical School (1981;245:1637). However, I wonder how different his experience was by virtue of his being a student at Harvard. Believe it or not, babies are delivered, suicide attempts are treated, and secrets are told at every medical school in the country, and  and hierarchy are not exclusively within the province of the major research schools. Moreover, I anticipate that in response to his article there will be some that follow with such titles as Third Year at Johns Hopkins, Second Year at Duke, and First Year at Yale, none of which would relate any experiences substantially different from those shared by medical students everywhere. Mr Bressler may have become infected with the same institutional pretense he decries.
Chronic back pain
Authors: C E Pither
Journal: BMJ (1994)

results were obtained for survival up to six months.The analysis was repeated for specific age groups: women aged 60-69 had a worse chance of survival to six months (P<003) but not to two years (P> 0075).No difference was found in either the younger or the older age groups.1.00 40-49 50-59 60-69 o .0cL 0.50 70-79 '.) 0.25 Men Women 0O O 16o 200 300 400 500 600 700 Time after infarction (days)Age specific Kaplan-Meier survival curves in men and women with acute myocardial infarction in first two years after admission to hospital (P>0 44)These Scottish data suggest that the poorer survival of women may be attributed to the different age distributions of the men and women admitted to hospital.The use of statistical methods that adjust for age across whole populations may, however, disguise differences in particular age groups' experience of disease.
Stress, Coping Behavior and Resistance to Disease
Authors: Michael Plaut, Stanford B. Friedman
Journal: Psychotherapy and Psychosomatics (1982)

Psychosocial factors affect resistance to a wide variety of diseases in animals. Stimuli often assumed to be noxious (e.g., electric shock, isolation housing) have been found to exert either potentiating or protective effects on an animal's response to potentially pathogenic stimulation. This variability has often been attributed to the influences of these stimuli on aspects of neuroendocrine or immunological function which are related to specific forms of pathogenic stimulation. The impact of a particular form of stimulation on the physiological state of the organism is also determined by the ability of the animal to cope with the stimulus environment. Factors shown to influence have included: (a) other aspects of the immediate environment at the time of stimulation; (b) prior experience with the same or other forms of stimulation; (c) the animal's ability to control its relationship to the stimuli by learning to escape or avoid them; (d) the availablility of relevant feedback regarding stimulus onset (e.g., warning signal), and (e) the stage of the disease process at which stimulation is imposed. These findings by various investigators indicate that it may be inappropriate to place a priori value judgements on any form of psychosocial stimulation or stress either as conceptually or operationally defined. The adaptive value of the psychosocial environment will depend upon its perception by the animal, the animal's ability to cope with the stimulus environment, and the particular disease system being studied.
Seven-year follow-up of heroin addicts: drug use and outcome.
Authors: G V Stimson, E Oppenheimer, A Thorley
Journal: BMJ (1978)

A representative sample of 128 of the patients who in 1969 attended London drug dependence clinics and received daily prescriptions for heroin was personally followed up seven years later. The mean age of the patients at follow-up was 32.7 years, and a mean of 12.8 years had elapsed since they first admitted to using heroin. Follow-up was successful in 124 cases (97%). Fifty-two people (41%) had stopped attending the clinics, 6 (5%) were in prison, 55 (43%) were still attending the clinics, and 15 (12%) had died. Abstinence from opiates had been achieved by at least 40 people, 33 having abstained for two years or more. Abstinence did not seem to have been replaced by dependence on other drugs, including alcohol. Sixty-two people (48%) were still using opiates; only 7 (5%) did so without attending clinics and obtaining legal prescriptions.
The shoulders of giants
Authors: Adam Weir, Johannes L Tol, Johannes Zwerver
Journal: British Journal of Sports Medicine (2013)

As far back as 1159 John of Salisbury realised, and later Newton acknowledged that advances in science were made by building on previous knowledge. They likened themselves to dwarves who were only able to discover distant wonders because they sat on the shoulders of giants. Although we have moved on nearly an entire millennium since this phrase was coined, the principle still holds up. Kentucky, while famous for fried chicken, also has some more healthy exports to its credit. The Second Scapular Summit, held in Lexington, lead to this month's consensus paper (dx.doi.org/10.1136/bjsports-2013-092425) which summarises the current state of affairs, allows us to elevate our knowledge and broadens our …
Lead Poisoning From Cocktail Glasses
Authors: Ethan A. Natelson, Herbert L. Fred
Journal: JAMA (1976)

When the cup of any sensual pleasure is drained to the bottom, there is always poison in the dregs. Jane Porter(1776-1850) A MAN and his wife acquired plumbism by drinking repeatedly from cocktail glasses decorated with lead-based paint. <h3>Report of Cases</h3> A 53-year-old geophysicist entered the coronary care unit for investigation of progressively severe precordial pain of three weeks' duration. He also complained of fatigue and constipation. For eight years, he had received methyldopa, 1 gm daily, as treatment for systemic arterial hypertension. On examination, his blood pressure was 140/90 mm Hg; pulse, 78 beats per minute; respiratons, 12/min; and temperature, 37 C. His cardiac and pulmonary findings were normal, and his liver and spleen were not enlarged. Chest roentgenogram and serial electrocardiograms were normal. Hemoglobin concentration, however, was 9.7 gm/100 ml and hematocrit reading, 30%. Total leukocyte count was 8,400/cu mm and platelet count, 350,000/cu mm. Reticulocyte count
Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation
Authors: Josep M. Llovet, Josep Fuster, Jordi Bruix
Journal: Hepatology (1999)

Liver transplantation is proposed as the best therapy for early hepatocellular carcinoma in cirrhotic patients. However, the confrontation with the results obtained by surgical resection has never been done on an intention-to-treat basis. Between 1989 and 1997, 164 out of 1,265 patients with hepatocellular carcinoma were evaluated for surgery. Seventy-seven (48 men, mean 61 years of age, 74 Child-Pugh class A, size 33 ± 18 mm) were resected (first line option) and 87 (65 men, mean 55 years of age, 50 Child-Pugh class B/C, size 24 ± 14 mm) were selected for transplantation. The 1-, 3-, and 5-year “intention-to-treat” survival was 85%, 62%, and 51% for resection and 84%, 69%, and 69% for transplantation (8 drop-outs on waiting list). Bilirubin and clinically relevant portal hypertension were independent survival predictors after resection. Thereby, the 5-year survival of the best candidates (absence of clinically relevant portal hypertension, n = 35) was 74%, whereas it was 25% for the worst candidates (portal hypertension and bilirubin ≥1 mg/dL, n = 27) ( P &lt; .00001). The variable “drop-out on waiting list” was the sole survival predictor after transplantation. The 2-year survival rate of patients evaluated for transplantation was 84% in the 1989 to 1995 period (mean waiting time, 62 days; no drop-outs) and 54% during 1996 to 1997 (mean waiting time, 162 days; 8 drop-outs)( P &lt; .003). This outcome was significantly lower than that of the best candidates for resection ( P = .002). In conclusion, a proper selection of candidates for resection promotes better results than transplantation, in which the results are significantly hampered by the growing incidence of drop-outs because of the increasing waiting time.
Harm Avoidance as a Mediator of Treatment Response to Antidepressant Treatment of Patients with Major Depression
Authors: Lena C. Quilty, Kathryn M. Godfrey, Sidney H. Kennedy, R. Michael Bagby
Journal: Psychotherapy and Psychosomatics (2010)

&lt;i&gt;Background:&lt;/i&gt; The temperament harm avoidance (HA) has consistently demonstrated an association with major depressive disorder (MDD), serotonin functioning and reduction in depression symptoms in response to antidepressant medications targeting the serotonin system. In the current investigation, we examine HA as a potential mediator of treatment response to a serotonergic tricyclic antidepressant. &lt;i&gt;Methods:&lt;/i&gt; Outpatients (n = 150) with MDD were randomized to receive clomipramine or a control treatment. Patients completed the Hamilton Rating Scale for Depression (Ham-D) and the Tridimensional Personality Questionnaire (TPQ) prior to treatment initiation, and then again after at least 8 weeks of treatment. Using structural equation modeling, we evaluated a ‘mediation model’ in which change in HA is a mechanism of depression change in response to clomipramine, and a ‘complication model’ in which reduction in HA is a by-product of depression change. &lt;i&gt;Results:&lt;/i&gt; The mediation model provided a good fit to the data by all indices, whereas the complication model did not. Patients treated with clomipramine exhibited a greater decrease in HA as compared to those in the control group; moreover, HA reduction was associated with depression reduction. &lt;i&gt;Conclusions:&lt;/i&gt; HA mediated the response to antidepressant treatment, such that any treatment effect of clomipramine occurred through HA reduction. Although replication with multiple assessment periods is required to determine if HA reduction actually precedes depression reduction, the results contribute to a growing body of literature implicating personality constructs subsumed within negative emotionality as mediators of treatment response to medications targeting serotonergic functioning.
Relation between Increased P Wave Duration Variability and Coronary Artery Disease with High Risk Parameters: Scintigraphic Evaluation
Authors: Osman Şahin, Gönül Zeren, Zeki Yüksel Günaydın, Özgür Enginyurt, Güney Erdoğan, Tuncay Kırış, Murat Selçuk, Ayşe Emre
Journal: Journal of the American College of Cardiology (2013)
Stimulant Medications in Tourette's Syndrome
Authors: Gerald S. Golden
Journal: JAMA (1982)

To the Editor.—  The recent article by Lowe et al highlights the potential for triggering Tourette's syndrome by administration of stimulant medication. In our experience with 80 children with Tourette's syndrome, eight (10%) had received stimulant drugs before their tics were manifest. 1 In six patients, typical symptoms developed within several weeks. The onset of Tourette's syndrome was rapid, remission did not occur when medication was discontinued, and response to haloperidol was good. Symptoms developed in the other two patients at a later time.  Twelve additional patients received stimulant drugs after the onset of symptoms. One half of these patients rapidly had a major increase in tics and vocalizations.  The summary of this experience is that 14 of 80 patients (18%) with Tourette's syndrome were exposed to stimulant drugs and responded adversely. An additional six patients (8% ) showed no obvious clinical response to these medications. Most of these patients were
Chondrosarcoma of the lobar bronchus with prolonged postoperative survival
Authors: PC Azimullah, JP Teengs, EJ Boerma
Journal: European Respiratory Journal (1994)

Primary chondrosarcoma originating from the bronchus is very rare. We describe the case of a 71 year old man with a large chondrosarcoma originating from the left lower lobe bronchus. The tumour was resected and, in contrast to most patients with such tumours, this patient is well, without complaints or abnormalities on X-ray or computed tomographic (CT) scan, 3 yrs after surgery. Tumour characteristics, symptoms, diagnosis and treatment are discussed. Radical surgical resection is the treatment of choice.
Impact of Glucose Self-Monitoring on Non-lnsulin-Treated Patients With Type II Diabetes Mellitus: Randomized Controlled Trial Comparing Blood and Urine Testing
Authors: B Titus Allen, Elizabeth R DeLong, John R Feussner
Journal: Diabetes Care (1990)

The goal of this study was to compare the relative efficacy and cost of self-monitoring of blood glucose (SMBG) with routine urine testing in the management of patients with type II (non-insulin-dependent) diabetes mellitus not treated with insulin. Fifty-four patients with type II diabetes mellitus, not treated with insulin, who had inadequate glucose control on diet aloneor diet and oral hypoglycemic agents were studied. Patients performed SMBG or urine glucose testing as part of a standardized treatment program that also included diet and exercise counseling. During the 6-mo study, both the urine-testing and SMBG groups showed similar improvement in glycemic control; within each group, there were significant improvements in fasting plasma glucose (reduction of 1.4 ± 3.2 mM, P &amp;lt; 0.03) and glycosylated hemoglobin (reduction of 2.0 ± 3.4%, P &amp;lt; 0.01) levels. Seventeen (31%) of54 patients actually normalized their glycosylated hemoglobin values, 9 in the urine-testing group and 8 in the SMBG group. Comparisons between the urine-testing and SMBG groups showed no significant differences in mean fasting plasma glucose (P &amp;gt; 0.86), glycosylated hemoglobin (P &amp;gt; 0.95), or weight (P &amp;lt; 0.19). In patients with type II diabetes mellitus not treated with insulin, SMBG is no more effective, but is 8–12 times more expensive, thanurine testing in facilitating improved glycemic control. Our results do not support widespread use of SMBG in diabetic patients not treated with insulin.