tbuckley/cabot-search huggingface dataset:
To-morrow's Doctors
Authors: J. R. Ellis
Journal: BMJ (1965)

The needs of medical education in the coming years, especially in the next decade, must obviously be related to the work which doctors should be doing during the remainder of this century.This lecture therefore falls naturally into three parts: (1) the task of the doctors of to-morrow; (2) the preparation which they will need to fit them for their task; and (3) the require- ments which must be met if that preparation is to be provided.
Risks of Energy Drinks Mixed With Alcohol
Authors: Jonathan Howland, Damaris J. Rohsenow
Journal: JAMA (2012)

The energy drink market is a multibillion-dollar industry that uses aggressive and innovative marketing strategies to target teens and young adults. Consequently, 31% of young teens and 34% to 51% of 18- to 24-year-olds report regular consumption of these products.1
DANGERS OF INTRODUCING IODIZED OIL INTO THE TRACHEOBRONCHIAL SYSTEM
Authors: EDWARD ARCHIBALD
Journal: JAMA (1927)

It is a matter of common observation that the advent of a new therapeutic or diagnostic measure may be accompanied by such a wave of enthusiasm in its favor that its field of acceptance and application early becomes extended beyond limits that are warranted by knowledge of its potential advantages or drawbacks—a knowledge which at first is inevitably incomplete. And it is not otherwise with the procedure indicated in the title of this paper. The truth of this reflection is being gradually attested in the rapidly increasing volume of the literature on this subject. One of us,<sup>1</sup>for instance, has already published two papers on the use of lipiodol, in the first of which his attitude was unreservedly favorable, while in the second, with larger experience, he urged caution in cases of tuberculosis. In the main, the articles hitherto published<sup>2</sup>emphasize the advantages of the method, though of
Lips as Red as Blood: Areca Nut Lip Staining
Authors: Lindsay M. Bicknell, Barry Ladizinski, Suzanne J. Tintle, Marigdalia K. Ramirez-Fort
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The Impossible Choice
Authors: Carl M. Kjellstrand
Journal: JAMA (1987)

"No, Doc," he said, "I can't stand it anymore. No one should have pain like this and when you give me the medicines I throw up and I see things that aren't there and I'm scared to death." He had been using the artificial kidney for five years. A proud and private man, he seemed to have no friends and did not get along well with the staff. Then he developed circulatory insufficiency, small-vessel disease, in both legs. There was nothing for the surgeons to do. When we tried analgesics we caused his nausea and changed unendurable pain to unendurable horrors of hallucinations that clouded his mind. When we treated the nausea it made the other things worse. All we could do was to amputate both legs. He refused to have that done and decided to stop dialysis and die. "Listen, Doc," he said. "I'm 68 years old, I live
Transference Interpretations in Dynamic Psychotherapy: Do They Really Yield Sustained Effects?
Authors: Per Høglend, Kjell-Petter Bøgwald, Svein Amlo, Alice Marble, Randi Ulberg, Mary Cosgrove Sjaastad, Øystein Sørbye, Oscar Heyerdahl, Paul Johansson
Journal: American Journal of Psychiatry (2008)

Transference interpretation has remained a core ingredient in the psychodynamic tradition, despite limited empirical evidence for its effectiveness. In this study, the authors examined long-term effects of transference interpretations.This was a randomized controlled clinical trial, dismantling design, plus follow-up evaluations 1 year and 3 years after treatment termination. One hundred outpatients seeking psychotherapy for depression, anxiety, personality disorders, and interpersonal problems were referred to the study therapists. Patients were randomly assigned to receive weekly sessions of dynamic psychotherapy for 1 year with or without transference interpretations. Five full sessions from each therapy were rated in order to document treatment fidelity. Outcome variables were the Psychodynamic Functioning Scales (clinician rated) and the Inventory of Interpersonal Problems (self-report). Rating on the Quality of Object Relations Scale (lifelong pattern) and presence of a personality disorder were postulated moderators of treatment effects. Change over time was assessed using linear mixed models.Despite an absence of differential treatment efficacy, both treatments demonstrated significant improvement during treatment and also after treatment termination. However, patients with a lifelong pattern of poor object relations profited more from 1 year of therapy with transference interpretations than from therapy without transference interpretations. This effect was sustained throughout the 4-year study period.The goal of transference interpretation is sustained improvement of the patient's relationships outside of therapy. Transference interpretation seems to be especially important for patients with long-standing, more severe interpersonal problems.
Conflicts of Interest, Continued-Reply
Authors: E. Haavi Morreim
Journal: JAMA (1990)

<h3>In Reply.—</h3> Although federal anti-kickback laws and the Inspector General's "safe harbor" guidelines apply to both Medicare and Medicaid, Rep Fortney Stark's bill does not. While my first mention of the bill (p 390) is limited to Medicare, the cited passage (p 391) wrongly adds Medicaid. Common law has not yet addressed physician investment and self-referral to ancillary facilities for the same reason that we do not yet have final legislation: the phenomenon itself is new, as recent cost-containment programs shift more care to outpatient settings and increasingly focus on physicians' incomes.<sup>1</sup> Abusive self-referral does cause injuries. Aside from the obvious harms of money wasted on needless and possibly iatrogenic tests or treatments, the deeper injury may be to the patient's trust when he or she discovers that the magnetic resonance imaging scan received at 2 AM could have been done more conveniently and less expensively by an identical,
Detection of allergens in a cat pelt extract
Authors: J. Azofra
Journal: Allergy (1992)

Allergenic components of cat pelt extract fractionated by SDS-polyacrylamide gel electrophoresis (PAGE) and transferred to nitrocellulose membranes were identified using sera from 15 allergic patients who showed positive skin test and RAST to cat extract. Two components showed the highest IgE-binding frequency; 14 kD (being recognized by 86% of the sera examined) and 29 kD (73% of the sera tested). Both components were purified by electroelution and subjected to RAST inhibition assays. The 29 kD fraction was able to bind specific IgE to D. pteronyssinus and inhibited a RAST assay of 29 kD component (Der p I) purified from a D. pteronyssinus extract. These results could explain the finding of positive skin test with some commercial cat allergen solutions in patients with D. pteronyssinus allergy.
paying to choose
Authors: Elizabeth Stafford
Journal: BMJ (2004)

Everyone likes the idea of choice. The world would be a boring place without it. When that choice extends to extending your chances of living a long and happy life rather than dying or being debilitated by coronary heart disease, it becomes even more appealing. If I ever had high cholesterol concentrations I would desperately attempt to alter my lifestyle, probably fail miserably, and end up back at the general practitioner with my cheque book in hand begging for the wonder drug …
Life Expectancy of Persons Receiving Combination Antiretroviral Therapy in Low-Income Countries: A Cohort Analysis From Uganda
Authors: Edward J. Mills, Celestin Bakanda, Josephine Birungi, Keith Chan, Nathan Ford, Curtis L. Cooper, Jean B. Nachega, Mark Dybul, Robert S. Hogg
Journal: Annals of Internal Medicine (2011)

Background: Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan Africa. Objective: To estimate life expectancy of patients once they initiate cART in Uganda. Design: Prospective cohort study. Setting: Public sector HIV and AIDS disease-management program in Uganda. Patients: 22 315 eligible patients initiated cART during the study period, of whom 1943 were considered to have died. Measurements: All-cause mortality rates were calculated and abridged life tables were constructed and stratified by sex and baseline CD4 cell count status to estimate life expectancies for patients receiving cART. The average number of years remaining to be lived by patients who received cART at varying age categories was estimated. Results: After adjustment for loss to follow-up, crude mortality rates (deaths per 1000 person-years) ranged from 26.9 (95% CI, 25.4 to 28.5) in women to 43.9 (CI, 40.7 to 47.0) in men. For patients with a baseline CD4 cell count less than 0.050 × 109 cells/L, the mortality rate was 67.3 (CI, 62.1 to 72.9) deaths per 1000 person-years, whereas among persons with a baseline CD4 cell count of 0.250 × 109 cells/L or more, the mortality rate was 19.1 (CI, 16.0 to 22.7) deaths per 1000 person-years. Life expectancy at age 20 years for the overall cohort was 26.7 (CI, 25.0 to 28.4) additional years and at age 35 years was 27.9 (CI, 26.7 to 29.1) additional years. Life expectancy increased substantially with increasing baseline CD4 cell count. Similar trends are observed for older age groups. Limitations: A small (6.4%) proportion of patients were lost to follow-up, and it was imputed that 30% of these patients had died. Few patients with a CD4 cell count greater than 0.250 × 109 cells/L initiated cART. Conclusion: Ugandan patients receiving cART can expect an almost normal life expectancy, although there is considerable variability among subgroups of patients. Primary Funding Source: Canadian Institutes of Health Research.
TRANSPLANTATION OF TOOTH GERM ELEMENTS AND THE EXPERIMENTAL HETEROTOPIC FORMATION OF DENTIN AND ENAMEL
Authors: C. B. Huggins, H. R. McCarroll, A. A. Dahlberg
Journal: The Journal of Experimental Medicine (1934)

The formation of dentin and enamel in the abdominal wall in young pups was achieved by transplantation of the soft tissues of the developing tooth germ. An interesting finding was the cytomorphosis of the epithelium of the enamel organ. When this was transplanted so that the ameloblasts were in contact with the odontoblasts the cylindrical character of the epithelial cells was preserved and enamel was produced; otherwise the cylindrical shape of these cells was lost and a stratified epithelium resulted, resembling the gingival and certain tumors (the adamantinoma) of the jaw and related structures. This degenerated epithelium did not produce enamel and had an important characteristic of not forming cysts in a closed connective tissue space, instead forming islands and cords of cells with epithelial pearl formation. Thus the influence of mesodermic connective tissue derivatives on the form and function of epithelium is presented. The odonto-blasts were found capable of survival as such and readily formed new dentin in transplantation; the stellate cells of the pulp were inert from the standpoint of inducing calcification.
Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema
Authors: A. JÄRVIKALLIO, A. NAUKKARINEN, I.T. HARVIMA, M.-L. AALTO, M. HORSMANHEIMO
Journal: British Journal of Dermatology (1997)

Journal Article Quantitative analysis of tryptase‐ and chymase‐containing mast cells in atopic dermatitis and nummular eczema Get access A. JÄRVIKALLIO, A. JÄRVIKALLIO Departments of Dermatology University Hospital, PO Box 1777, 70211 Kuopio, Finland Search for other works by this author on: Oxford Academic Google Scholar A. NAUKKARINEN, A. NAUKKARINEN Departments of Dermatology University Hospital, PO Box 1777, 70211 Kuopio, Finland Search for other works by this author on: Oxford Academic Google Scholar I.T. HARVIMA, I.T. HARVIMA Departments of Pathology, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland Search for other works by this author on: Oxford Academic Google Scholar M.‐L. AALTO, M.‐L. AALTO Departments of Pathology, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland Search for other works by this author on: Oxford Academic Google Scholar M. HORSMANHEIMO M. HORSMANHEIMO Departments of Dermatology University Hospital, PO Box 1777, 70211 Kuopio, Finland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 6, 1 June 1997, Pages 871–877, https://doi.org/10.1046/j.1365-2133.1997.01831.x Published: 01 June 1997 Article history Accepted: 12 December 1996 Published: 01 June 1997
Serrated adenomas in FAP
Authors: M C Gallagher
Journal: Gut (2002)

<h3>Introduction</h3> The direct aspiration first pass technique (ADAPT) has been introduced as a rapid and safe endovascular treatment strategy in patients with ischemic stroke. <h3>Objective</h3> To determine the technical feasibility, safety, and functional outcome with ADAPT using the new large-bore 6F SOFIA Plus catheter. <h3>Methods</h3> A retrospective analysis of prospectively collected data from six university hospitals was performed. The following parameters of all acute stroke procedures (June 2015– January 2016) using the SOFIA Plus catheter were analyzed: accessibility of the thrombus with the catheter, recanalization success (Thrombolysis in Cerebral Infarction ≥2b), time to recanalization, procedure-related complications. Furthermore, National Institutes of Health Stroke Scale (NIHSS) scores at presentation and discharge and the modified Rankin scale (mRS) score at 90 days were recorded. <h3>Results</h3> 85 patients were treated using the SOFIA Plus catheter. The occlusion site was the anterior circulation in 94.1%. Median baseline NIHSS score was 18. In 64.7%, ADAPT alone was successful after a median procedure time of 21 min. With additional use of stent retrievers in the remaining cases, the recanalization rate was 96.5%. No catheter-related complications such as dissections were observed. Thrombus migration to a new vascular territory occurred in 4.7% and symptomatic hemorrhage in 4.7%. After 3 months, mRS 0–2 was achieved in 49.4%. Mortality rate was 20%. <h3>Conclusions</h3> In the majority of cases, thrombus aspiration using the SOFIA Plus catheter results in successful recanalization after a short procedure time. With additional use of stent retrievers, a high recanalization rate can be achieved (96.5%). The complication rate was in line with those of previous publications.
Sixty Years of Neurological Surgery
Authors: Paul C. Bucy
Journal: JAMA (1988)

I first became interested in neurological surgery during my freshman year as a medical student at the University of Iowa in 1923. During a neuroanatomy course in which we used a textbook written by Stephen Walter Ranson, I became intrigued with the way he posed problems of lesion localization in the nervous system. My interest grew during the following summer when I had the opportunity to work with a general surgeon, John O'Keefe, who allowed me to study his patients with neurological disorders. When I returned to Iowa City that autumn I went directly to the professor of psychiatry and neuropathology, Samuel T. Orton, and told him of my desire to pursue a career in neurological surgery. He advised me first to learn more about the pathology of the nervous system—a wise recommendation. To begin, I studied a newly published book on gliomas of the nervous system, written by Percival
Increased Lead Biomarker Levels Are Associated with Changes in Hormonal Response to Stress in Occupationally Exposed Male Participants
Authors: Marie C. Fortin, Deborah A. Cory-Slechta, Pamela Ohman-Strickland, Chizoba Nwankwo, T. Steven Yanger, Andrew C. Todd, Jan Moynihan, James Walton, Andrew Brooks, Nancy Fiedler
Journal: Environmental Health Perspectives (2011)

Lead (Pb) exposure has been associated with a host of pathological conditions in humans. In rodents Pb exposure has been shown to alter the hypothalamic-pituitary-adrenal (HPA) axis function.We investigated the effects of lead on responses of the HPA axis to a psychosocial laboratory stressor administered to Pb-exposed workers.Seventy male participants completed the Trier Social Stress Test (TSST). Serum cortisol (CORT) and plasma adrenocorticotropic hormone (ACTH) were assessed in response to and during recovery from the stressor. We measured Pb in blood, a biomarker of recent exposure, and in tibia bone by X-ray fluorescence (XRF), a biomarker of chronic exposure.The TSST induced statistically significant increases in ACTH and CORT in the participants. At baseline, ACTH was not significantly higher (p = 0.052) in participants with higher blood Pb concentration, but CORT was significantly lower in these participants (p = 0.016). Adjusted linear regression models indicated a positive association between blood and bone Pb and the increase in ACTH in response to stress. However, Pb was not strongly associated with changes in CORT in response to stress. Pb was also associated with the ACTH:CORT ratio at baseline and throughout the course of the protocol, suggesting an adrenal hyporesponsiveness in participants with higher Pb concentrations.The altered HPA-axis stress response observed in participants exposed to higher levels of Pb further supports the idea that lead may contribute to a host of biological dysfunctions beyond the classical neurotoxic effects.
MUNICIPAL HOSPITALS AND THEIR RELATION TO THE COMMUNITY
Authors: RUPERT NORTON
Journal: JAMA (1913)

Speaking broadly it may be said, without fear of contradiction, that the municipal hospitals of this country are a disgrace from almost every point of view and do not serve the purpose they should in any respect. The exceptions can be counted without difficulty on one's fingers. One of the best is the Boston City Hospital, and the worst, considering the city in which it is situated, is the Cook County Hospital of Chicago. Between these two there are hospitals of all grades. The new Bellevue Hospital in New York could in a few years become a noteworthy institution, but there are many conditions which stand in the way of its development along the best lines possible. In Baltimore there is the beginning of an excellent institution. The same may be said of Cincinnati and of some other cities. Throughout the country there are many well-built hospitals, but there their
Splenic Metastasis of Hepatocellular Carcinoma Accumulation of Tc-99m HDP
Authors: HAJIME FUJIMOTO, KOJI MURAKAMI, KENJI NOSAKA, NOBORU ARIMIZU
Journal: Clinical Nuclear Medicine (1992)

Considerable accumulation of Tc-99m HMDP was noted in a huge splenic mass in a 62-year-old man with hepatocellular carcinoma. An autopsy revealed a massive hemorrhage within the splenic metastasis. The splenic uptake of the radionuclide corresponded to the marked deposition of hemosiderin.
Monomeric chemically modified allergens: immunologic and Physicochemical characterigation
Authors: G. Mistrello, O. Brenna, D. Roncarolo, D. Zanoni, M. Gentili, P. Falagiani
Journal: Allergy (1996)

Allergenic extracts ( Der p , grass, and Parietarin ) or single allergens such as Par j I (the major allergen of Parietaria ) and ovalbumin (OA), a food allergen widely used in animal models, were chemically modified by reaction with potassium cyanate (KCNO), which transforms the &amp;‐amino group of the lysine of proteinaceous allergens into ureido groups. KCNO‐modified (carbamylated) allergens have low allergenic potency, as demonstrated in vitro (RAST inhibition) and in vivo (passive cutaneous anaphylaxis). When used to immunize rabbits, carbamylated allergens still induce IgG antibodies able to cross‐react with native allergens (immunoblotting experiments). An interesting feature distinguishing carbamylated allergens from other chemically modified allergens is the preservation of the native monomeric dimension as demonstrated by SDS‐PAGE analysis. Results are discussed from the perspective of clinical application of carbamylated allergens.
Smaller families aid economic growth, says UN report
Authors: Z. Kmietowicz
Journal: BMJ (2002)

Women in developing countries need better contraceptive care and education and equal rights if world poverty is to be tackled effectively, says a report published this week. It shows that more than one billion people live on less than $1 (64p; €1) a day, with little change in this figure in the past 14 years.

The 25th “state of world population” report from the United Nations Population Fund shows for …
Small intestinal perforation of endoscopically unrecognized lesions during peroral single-balloon enteroscopy
Authors: K. Tominaga, T. Iida, Y. Nakamura, J. Nagao, Y. Yokouchi, I. Maetani
Journal: Endoscopy (2008)

A 79-year-old man presented with a 2-month history of abdominal pain. Computed tomography (CT) showed an abdominal tumor, peritoneal dissemination, and ascites ([Fig. 1]). Total colonoscopy, including observation of the terminal ileum and esophagogastroduodenoscopy, showed no specific findings. However, because of abnormal radiographic findings of the jejunum, a single-balloon enteroscopy was performed via the anterograde approach using an enteroscope (SIF-Q260; Olympus, Tokyo, Japan) with a flexible overtube (ST-SB1; Olympus) [1] [2]. The patient was sedated with midazolam (10 mg IV) but complained of abdominal pain during insertion of the endoscope into the jejunum. Perforation was suspected under fluoroscopy before the endoscope had encountered any lesions. The enteroscope was withdrawn and abdominal radiograph and CT scan suggested intestinal perforation ([Fig. 2]). The small intestine was partially resected because the site of the perforation had been confirmed during the laparotomy. Multiple whitish tumors had metastasized mainly to the serosa of the intestine and peritoneum. Gross pathological examination revealed that metastatic tumors had invaded from the serosa into the mucosa and created multiple ulcers, one of which was perforated ([Fig. 3]). Histology of the site of perforation revealed a diffuse infiltrate of tumor cells involving all layers of the small intestinal wall ([Fig. 4]). Although the tumors were diagnosed as metastatic carcinoma by further immunohistochemical examination, a diagnosis of metastatic carcinoma of unknown origin was made because further clinical investigations could not confirm the primary site of the carcinoma.