Celiac Disease during Interferon Treatment
Authors: Maria Teresa Bardella, Roberta Marino, Pier Luigi Meroni
Journal: Annals of Internal Medicine (1999)

Letters20 July 1999Celiac Disease during Interferon TreatmentMaria Teresa Bardella, MD, Roberta Marino, MD, and Pier Luigi Meroni, MDMaria Teresa Bardella, MDIRCCS Ospedale Maggiore; Milan, Italy (Bardella)IRCCS Ospedale Maggiore; Milan, Italy (Marino)IRCCS Ospedale Maggiore; Milan, Italy (Meroni), Roberta Marino, MDIRCCS Ospedale Maggiore; Milan, Italy (Bardella)IRCCS Ospedale Maggiore; Milan, Italy (Marino)IRCCS Ospedale Maggiore; Milan, Italy (Meroni), and Pier Luigi Meroni, MDIRCCS Ospedale Maggiore; Milan, Italy (Bardella)IRCCS Ospedale Maggiore; Milan, Italy (Marino)IRCCS Ospedale Maggiore; Milan, Italy (Meroni)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-2-199907200-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Interferon (IFN) therapy provides a potentially effective treatment for patients with chronic viral hepatitis. However, because underlying autoimmune diseases can appear or worsen during IFN therapy, it is mandatory to exclude their presence and to check for specific autoantibodies before treatment begins and during the follow-up (1, 2). In susceptible patients, celiac disease is caused by dietary exposure to gliadin, an alcohol-soluble extract of wheat, rye, and barley. The exact mechanism of damage is not known, but gliadin-triggered autoimmune mechanisms may play a role (3). In addition, celiac disease is often associated with other autoimmune diseases (4).... References1. Guidelines for the treatment of chronic viral hepatitis. Position paper. Committee for antiviral therapy of the Italian Association for the Study of the Liver (A.I.S.F.). Ital J Gastroenterol Hepatol. 1997; 29:597-600. Google Scholar2. Preziati D, La Rosa L, Covini G, Marcelli R, Rescalli S, Persani L, et al . Autoimmunity and thyroid function in patients with chronic active hepatitis treated with recombinant interferon α-2a. Eur J Endocrinol. 1995;132:587-93. CrossrefMedlineGoogle Scholar3. Maku M, Collin P. Coeliac disease. Lancet. 1997;1:1755-9. CrossrefGoogle Scholar4. Halsted CH. The many faces of celiac disease. N Engl J Med. 1996;334:1190-1. CrossrefMedlineGoogle Scholar5. Trier JS. Celiac sprue. N Engl J Med. 1991;325:1709-19. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Maria Teresa Bardella, MD; Roberta Marino, MD; Pier Luigi Meroni, MDAffiliations: IRCCS Ospedale Maggiore; Milan, Italy (Bardella)IRCCS Ospedale Maggiore; Milan, Italy (Marino)IRCCS Ospedale Maggiore; Milan, Italy (Meroni) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAre Viruses and Parasites Linked to Celiac Disease? 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