tbuckley/cabot-search huggingface dataset:
Grain Dust and Health. IV. Health Surveillance Programs
Authors: James A. Dosman, David J. Cotton
Journal: Annals of Internal Medicine (1978)

Symposium1 October 1978Grain Dust and Health. IV. Health Surveillance ProgramsJAMES A. DOSMAN, M.D., F.R.C.P. (C), DAVID J. COTTON, M.D., F.R.C.P. (C)JAMES A. DOSMAN, M.D., F.R.C.P. (C)Search for more papers by this author, DAVID J. COTTON, M.D., F.R.C.P. (C)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-570 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discussion, based on the six tabled papers (1-6), took place in two sessions before the reaching of a general consensus and the chairman's report (7). As might be expected, points of view tended to be different between participants representing different interest groups. Previously reported workshops have identified potential health hazards affecting workmen in the cereal grain storage and transporting industry, discussed methods of early and late diagnosis, and outlined current knowledge regarding environmental factors relating to grain dust and health.Although the purpose of the workshop was not to critique the requirements for an environmental and medical surveillance program...References1. ARHIRII M: Rationale and methods in devising a health surveillance program in the grain industry. McGill University, Mont Saint Hilaire, Quebec, Canada; and Occupational Health Unit, Health and Welfare Canada, Ottawa, Ontario, Canada Google Scholar2. MCCARTHY T: Dust exposures in the Canadian grain industry. Health and Welfare Canada, Ottawa, Ontario, Canada Google Scholar3. FINN W: Health hazards from grain dust in Canadian grain elevators. University of British Columbia, Vancouver, British Columbia, Canada Google Scholar4. ELLIOTT G: Problems related to compensation. Worker's Compensation Board, Regina, Saskatchewan, Canada Google Scholar5. PIGHIN A: Problems inherent in environmental monitoring programs; their relationship to health surveillance programs. Labour Canada, Ottawa, Ontario, Canada Google Scholar6. DENNIS C: Methods used in the health surveillance of Saskatchewan farmers and grain elevator operators, 1968-75. The Prairie Institute of Environmental Health, Regina, Saskatchewan, Canada Google Scholar7. BATES D: Chairman's Summary of the Workshop on Health Surveillance Programs. University of British Columbia, Vancouver, British Columbia, Canada Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAssociation Between Pulmonary Dysfunction as a Result of Occupational Exposures and Risk of Developing CancerIncreased Bronchial Reactivity to Inhaled Histamine in Nonsmoking Grain Workers with Normal Lung Function 1 October 1978Volume 89, Issue 4Page: 570-571KeywordsDustEnvironmental health Issue Published: 1 October 1978 PDF DownloadLoading ...
Ectopic hair on the glans penis
Authors: M. Braun-Falco, F-M. Kohn
Journal: British Journal of Dermatology (2005)

Sir, Hair growth at a distinct part of the body, which normally does not exhibit hair follicle development, such as the palms and soles or in particular the glans penis, is extremely unusual. Here, we present a healthy 24‐year‐old man with an 18‐month history of a symptomless strand‐like thickening on his glans penis. Five months previously an outgrowth of hair was noted. Previous trauma, manipulations or unusual sexual habits were denied by the patient. Skin examination revealed a 3–4‐cm long, 2–3‐mm thick indurated canal with a vessel‐like blue discoloration which started at the corona laterally from the frenulum and ran in a U‐curve to the right part of the glans (Fig. 1a). At the end of the canal shortly before it again reached the corona, the skin was pervaded by a bunch of hairs. At the distal penile shaft a small raphe cyst underneath the frenulum was detectable without any association to the canal. After incisional opening of the canal, more than 30 up to 3‐cm‐long black and blond hairs appeared (Fig. 1b). Histopathological evaluation of the canal at its proximal part demonstrated an almost normal hair follicle containing numerous hair shafts (Fig. 1c). No recurrence occurred at the site of excision, but after 6 months new hair growth was noted at a different location on the glans, which again required excision.
Cholesterol and Coronary Heart Disease Risk in Elderly Patients-Reply
Authors: Harlan M. Krumholz
Journal: JAMA (1995)

<h3>In Reply.</h3> —Drs Harris, Ettinger, and Havlik suggest that our results may be due to the "unique" characteristics of our sample. The only unique feature of our sample is that it is truly representative of the elderly population in contemporary urban society. This sample is as appropriate for studying the association of cholesterol and adverse outcomes as many other studies that have included a narrower spectrum of subjects. It would be unfortunate for experts to marginalize our study because it included substantial numbers of women, African Americans, and individuals subsisting with limited resources. These investigators raise an important concern that subjects with low cholesterol levels had poor health status. In unpublished analyses, we found no significant differences between the cholesterol groups with respect to overall health status, functional status, cognitive function, psychosocial support, or socioeconomic status. To evaluate the potential association of low cholesterol levels with early mortality, we repeated
Arthur Conan Doyle
Authors: Allen S. Johnson
Journal: New England Journal of Medicine (1953)

ARTHUR CONAN DOYLE was born in Edinburgh in 1859, the fourth of 10 siblings. His parents were Irish Catholics of distinguished, but by no means affluent, ancestry that was endowed with considerable artistic talent on the paternal side. Arthur's formal education was under Jesuit auspices, first at Stonyhurst and then at Feldkirch in western Austria. It was during his year on the Continent that he was first introduced to the mysteries of Edgar Allan Poe, whose C. Auguste Dupin was the forerunner of Sherlock Holmes and of today's fictional analytical detectives.Doyle's mother seems to have chosen the career of . . .
Retrospective Evaluation of the Outcome of Open Versus Laparoscopic Adrenalectomy for Stage I and II Adrenocortical Cancer
Authors: Francesco Porpiglia, Cristian Fiori, Fulvia Daffara, Barbara Zaggia, Enrico Bollito, Marco Volante, Alfredo Berruti, Massimo Terzolo
Journal: European Urology (2010)
lndium-111 Labeled Leukocyte Imaging Following Hepatic Artery Embolization
Authors: ROBERT J. WITTE, RICHARD J. PETERSEN, SAM C. AUGUSTINE, JOEL D. ELSON
Journal: Clinical Nuclear Medicine (1986)

The use of In-111 labeled leukocytes for abscess localization is becoming well established. The first report of In-111 imaging following hepatic embolization is presented. A 45-year-old man with adenocarcinoma of the colon and metastatic liver disease was treated for intractable pain using particulate embolization of the hepatic artery. In-111 leukocyte imaging was performed to rule out abscess formation. The distribution of the labeled leukocytes demonstrated hepatic uptake commensurate with Tc-99m sulfur colloid (SC) images. Areas of embolization did not accumulate tracer. Pathologic examination at autopsy correlated with the distribution of the labeled leukocytes. Thus, therapeutic embolization did not alter the normal distribution of this tracer in functional hepatic tissue.
Concomitant treatment of psoriasis of the hands and feet with pulsed dye laser and topical calcipotriol, salicylic acid, or both: A prospective open study in 41 patients
Authors: Jaap de Leeuw, Bhupendra Tank, Peter J. Bjerring, Suzanne Koetsveld, Martino Neumann
Journal: Journal of the American Academy of Dermatology (2006)
Alteration of growth responses in established cardiac pressure overload hypertrophy in rats with aortic banding.
Authors: H Schunkert, E O Weinberg, G Bruckschlegel, A J Riegger, B H Lorell
Journal: Journal of Clinical Investigation (1995)

We examined the acute effects of elevated wall stress, norepinephrine, and angiotensin II on cardiac protein synthesis as well as protooncogene expression in hearts with established pressure overload left ventricular hypertrophy. Isolated rat hearts with chronic hypertrophy (LVH) were studied 12 wk after ascending aortic banding when systolic function was fully maintained. New protein synthesis (incorporation of [3H]phenylalanine [Phe]) was analyzed in isolated perfused rat hearts after a 3-h protocol; c-fos, c-jun, c-myc, and early growth response gene-1 (EGR-1) mRNA levels (Northern blot) were studied over a time course from 15 to 240 min of perfusion. Under baseline conditions (i.e., before mechanical or neurohormonal stimulation), [3H]-Phe-incorporation (280 nmoles/gram protein/h) and protooncogene mRNA levels were similar in age-matched control and LVH hearts. However, hearts with chronic LVH were characterized by a markedly blunted or absent [3H]-Phe-incorporation after acute imposition of isovolumic systolic load (90 mmHg/gram left ventricle), as well as norepinephrine (10(-6)M), or angiotensin II infusion (10(-8)M plus prazosin 10(-7)M) compared with nonhypertrophied control hearts. Similarly, stimulation of LVH hearts with acute systolic load or norepinephrine was associated with a significantly blunted increase of protooncogene mRNA levels relative to control hearts. The blunted induction of c-fos mRNA in LVH hearts was not due to feedback inhibition, since cycloheximide perfusion of hearts exposed to elevated wall stress further increased the differences between age-matched control and LVH hearts. The data suggest that acute molecular growth responses to mechanical or neurohormonal stimulation are altered in rat hearts with established LVH relative to nonhypertrophied control hearts. This alteration of molecular adaptations in hearts with compensatory hypertrophy may prevent inappropriate excess cardiac growth in response to mechanical and neurohormonal stimuli.
T Lymphocytes Transduced with a Lentiviral Vector Expressing F12-vif Are Protected from HIV-1 Infection in an APOBEC3G-Independent Manner
Authors: Giuliana Vallanti, Rossella Lupo, Maurizio Federico, Fulvio Mavilio, Chiara Bovolenta
Journal: Molecular Therapy (2005)

The viral infectivity factor (Vif) is an essential component of the HIV-1 infectious cycle. Vif counteracts the action of the cytidine deaminase APOBEC3G (AP3G), which confers nonimmune antiviral defense against HIV-1 to T lymphocytes. Disabling or interfering with the function of Vif could represent an alternative therapeutic approach to AIDS. We have expressed a natural mutant of Vif, F12-Vif, in a VSV-G-pseudotyped lentiviral vector under the Tat-inducible control of the HIV-1 LTR. Conditional expression of F12-Vif prevents replication and spreading of both CXCR4 and CCR5 strains of HIV-1 in human primary T lymphocyte and T cell lines. T cells transduced with F12-Vif release few HIV-1 virions and with reduced infectivity. Several lines of evidence indicate that HIV-1 interference requires the presence of both wild-type and F12-Vif proteins, suggesting a dominant-negative feature of the F12-Vif mutant. Surprisingly, however, the F12-Vif-mediated inhibition does not depend on the reestablishment of the AP3G function.
CASE OF OBSTRUCTED LABOUR DUE TO OSTEO-SARCOMA OF PELVIS
Authors: M. B. Ray
Journal: BMJ (1907)

PELVIC OSTEO-SARCOYIA OBSTRUCTING LA.BOUR.[IM JOAL I '9In these cases a general cause could be put out at once, as also any question of any of the infectious diseases, and we are left with:1.The bursting of a small ovarian cyst, causing baemorrhage into its interior and subsequent rupture in .onecase.
IN WHAT CLASS OF WOUNDS SHALL WE USE DRAINAGE? AND THE PRESENT POSITION OF ANTISEPTIC SURGERY.Abstract of a paper read before the Gynœcological Society of Boston, October 9, 1890.
Authors: HENRY O. MARCY
Journal: JAMA (1891)

Dr. Marcy considered at length the subject viewed from the standpoint of the recent discussion at the International Medical Congress held in Berlin. He reviewed in detail the observations of Metschnikoff upon the power of the leucocytes to surround and destroy, to digest (so to speak), the bacteria when circumstances are favorable. It seemed to the writer quite too early to draw general deductions from these premises and declare that here the entire solution of the problem is found. There is every reason, however, to believe that this is an important discovery of a power which the organism brings to rescue it under favorable conditions from impending danger. The practical deduction of the lesson is that we seek to place the wound in such a condition that the phagocytes of Metschnikoff may be made the active allies of the surgeon. All this helps also, in a measure, to explain the
Fluid status monitoring with a wireless network to reduce cardiovascular-related hospitalizations and mortality in heart failure: rationale and design of the OptiLink HF Study (Optimization of Heart Failure Management using OptiVol Fluid Status Monitoring
Authors: Johannes Brachmann, Michael Böhm, Karin Rybak, Gunnar Klein, Christian Butter, Hanno Klemm, Rolf Schomburg, Johannes Siebermair, Carsten Israel, Anil-Martin Sinha, Helmut Drexler
Journal: European Journal of Heart Failure (2011)
New data: Old pitfalls
Authors: Alan Baddeley
Journal: Behavioral and Brain Sciences (2003)

Ruchkin et al.'s theoretical conclusions reflect two venerable fallacies. They confound an experimental paradigm with a theoretical concept, and they assume that features of the paradigm that are most readily detected by their methods provide an adequate account of the operation of the theoretical system. This results in a simplistic theory that does not do justice to the richness of the available data.
Destroy the bleeding vessels and spare the ischemic mucosa
Authors: B. Maroy
Journal: Endoscopy (2008)

I agree with the statement of H. J. N. Andreyev regarding the use in chronic radiation proctitis of argon plasma coagulation (APC) [1]. Chronic radiation proctitis is basically an ischemic disease where the mucosa is affected. Therefore, any further aggressive action against the overlying epithelium is to be avoided whenever possible. Argon coagulation destroys bleeding vessels [2] but also mucosa and submucosa, and therefore predisposes to later ulcerations which heal slowly, if ever.
THE USE AND ABUSE OF BONE GRAFTS
Authors: T. P. McMurray
Journal: BMJ (1917)

begin with explaining it: after which I shall give an Account of the Book itself.But in 'the first place I must take notice of two Pieces which have been published upon a subject akin to this, though they differ a good deal from it; the' first in the year 1584, by Sc6vole de Saint-Marthe, and the second in the year 1656 by Claude Quillet.As to the Title, I have formed it of two Greek Words-namely, ;pOs, which signifies straight, free from Deformity, and va,Siov, a child.Out of these two Words I have compounded that of Orthopaedia, to express in one Term the Design I propose, which is to-teach the different Methods of preventing and correcting the Deformities of Children.
Physician Bias in Cesarean Sections
Authors: Robin N. Phillips
Journal: JAMA (1982)

Various aspects of physician bias in the decision to perform a cesarean section were investigated by comparing indications for cesarean sections for 1979 and 1980 and investigating the distribution of indications according to the day of the week. The contention that obstetricians may perform cesarean sections on weekends for secondary gain was refuted by showing no difference in the distribution of nonelective cesarean section indications between weekdays and weekends. Statistically significant changes in cesarean section indications were, however, observed between the two investigated years, which may be attributed to an organizational change within the department toward more sophisticated obstetric care. These changes included a significant increase in cesarean sections for dystocia and breech presentation and a decrease for fetal distress and "other" indications. Because the total cesarean section rate did not change during the study periods, it is suggested that modern obstetric practice per se does not increase cesarean section rates, but may shift the distribution of indications for cesarean section.
Distribution, blood transport, and degradation of antidiuretic hormone in man.
Authors: G Baumann, J F Dingman
Journal: Journal of Clinical Investigation (1976)

The distribution, blood transport, and metabolic clearance of physiological concentrations of antidiuretic hormone were studied in 10 hydrated normal subjects with radioiodinated arginine vasopressin (125I-AVP). At 37 degrees C no binding of 125I-AVP to plasma proteins could be demonstrated, but some metabolites were associated with plasma proteins. 125I-AVP was rapidly distributed into a space approximating the extracellular fluid volume. Metabolic breakdown products became demonstrable within minutes after injection. The mean metabolic clearance rate of 125I-AVP was 4.1 ml/min/kg and the mean plasma half-life 24.1 min. Renal clearance had a mean value of 80 ml/min and accounted for 27% of the total metabolic clearance. It is concluded that in man antidiuretic hormone circulates as a free (non-protein bound) peptide, diffuses readily into the extracellular fluid space, and is metabolized within minutes. A plasma half-life of 24 min is consistent with the duration of antidiuresis after hormone administration or release.
A Prevalent Misconception Regarding Wide-Complex Tachycardias
Authors: Fred Morady, Jeffrey M. Baerman, Lorenzo A. DiCarlo, Michael DeBuitleir, Ryszard B. Krol, Dennis W. Wahr
Journal: JAMA (1985)

In response to a questionnaire, 59% of 196 physicians indicated that they were influenced by a patient's blood pressure and clinical status when attempting to distinguish ventricular tachycardia (VT) from paroxysmal supraventricular tachycardia with bundle-branch block. A sizable proportion of physicians are unaware that VT need not be associated with shock. More emphasis should be placed on making physicians aware that the differentiation of VT from paroxysmal supraventricular tachycardia should be based on electrocardiographic findings and not on the patient's blood pressure or clinical status.
Diabetes and Decline in Heart Disease Mortality in US Adults
Authors: Ken Gu
Journal: JAMA (1999)

Mortality from coronary heart disease has declined substantially in the United States during the past 30 years. However, it is unknown whether patients with diabetes have also experienced a decline in heart disease mortality.To compare adults with diabetes with those without diabetes for time trends in mortality from all causes, heart disease, and ischemic heart disease.Representative cohorts of subjects with and without diabetes were derived from the First National Health and Nutrition Examination Survey (NHANES I) conducted between 1971 and 1975 (n = 9639) and the NHANES I Epidemiologic Follow-up Survey conducted between 1982 and 1984 (n = 8463). The cohorts were followed up prospectively for mortality for an average of 8 to 9 years.Changes in mortality rates per 1000 person-years for all causes, heart disease, and ischemic heart disease for the 1982-1984 cohort compared with the 1971-1975 cohort.For the 2 periods, nondiabetic men experienced a 36.4% decline in age-adjusted heart disease mortality compared with a 13.1% decline for diabetic men. Age-adjusted heart disease mortality declined 27% in nondiabetic women but increased 23% in diabetic women. These patterns were also found for all-cause mortality and ischemic heart disease mortality.The decline in heart disease mortality in the general US population has been attributed to reduction in cardiovascular risk factors and improvement in treatment of heart disease. The smaller declines in mortality for diabetic subjects in the present study indicate that these changes may have been less effective for people with diabetes, particularly women.
Congress Moving to Improve FDA Performance
Authors: Charles Marwick
Journal: JAMA (1996)

AFTER MONTHS of talk about shortcomings in the way the Food and Drug Administration (FDA) goes about its job, Congress is finally moving toward developing comprehensive legislation that will, it is hoped, improve the agency's performance. Sen Nancy Kassebaum (R, Kan), chair of the Labor and Human Resources Committee, is holding congressional hearings on legislation she introduced in December. On the House side, Thomas J. Bliley, Jr (R, Va), chair of the Commerce Committee, has promised that he too will hold hearings on legislation that he proposes to introduce. Bliley has been a severe critic of the agency. Although not all will agree that Kassebaum's bill is the perfect solution to resolving the problems that many say plague the FDA and regardless of the outcome, her bill has substantially moved the debate about the agency's performance from charges and countercharges to a serious effort at reform. The US Congress has
Anaphylaxis in an emergency setting – elicitors, therapy and incidence of severe allergic reactions
Authors: K. Beyer, O. Eckermann, S. Hompes, L. Grabenhenrich, M. Worm
Journal: Allergy (2012)

Anaphylaxis is a severe potentially life-threatening hypersensitivity reaction with an estimated lifetime prevalence of 0.5-2.0%. The prevalence and incidence of anaphylactic reactions in Germany are unknown. We therefore assessed anaphylactic patients seen by emergency physicians in the Berlin area covering 4 million people.A standardised questionnaire was filled from 2008 to 2010 by the emergency physicians.A total of 333 cases of anaphylaxis were reported. 295 of these met the inclusion criteria for severity and were analysed. 13.9% (n = 41) were reactions with respiratory symptoms, 25.4% (n = 75) with cardiovascular, and in 60.7% (n = 179) of cases, respiratory and cardiovascular symptoms were reported. Two reactions were fatal. The most common elicitors were food products (32.2%), drugs (29.2%) and insect venom (19.3%). The most frequently given drugs were corticoids and antihistamines, but not adrenaline. For 2008, the calculated incidence was 4.5 per 100 000.Our data show that food products are frequent elicitors of severe allergic reactions in the general population including children and adults. It unravels a strong underuse of adrenaline by emergency physicians, not reflecting treatment protocols according to the current guidelines. As data obtained from allergists reveal a different rank order of elicitors, this study suggests that food-allergic adult patients may present a risk population and should receive more attention by allergists.
Drug Resistance and R Factors in the Bowel Bacteria of London Patients before and after Admission to Hospital
Authors: N. Datta
Journal: BMJ (1969)

The content of drug-resistant coliform bacteria in faecal specimens collected before admission from patients awaiting non-urgent surgery were compared with specimens collected in hospital. Resistant strains of Escherichia coli were isolated from 52% of preadmission specimens and were present in large numbers in 28%. Tetracycline, sulphonamide, and streptomycin resistance were commonest: 60% of resistant strains carried transmissible R factors and multiple resistance was commoner than single. No characteristically resistant intestinal bacteria of any genera were found in hospital specimens as compared with those from outside.
944-68 A Comparison Between the Pro-Arrhythmic Effect of Almokalant and d-Sotalol In an Animal Model of Torsade de Polntes Arrhythmias
Authors: S. Cora Verduyn, Marc A. Vos, Jalanda van der Zande, Hein J.J. Wellens
Journal: Journal of the American College of Cardiology (1995)