tbuckley/cabot-search huggingface dataset:
Current Status of Argon Laser Hemostasis of Bleeding Ulcers
Authors: J.M. Brunetaud, D.M. Jensen
Journal: Endoscopy (1986)

Endoscopic argon laser photocoagulation has been extensively studied in animals. Clinical pilot studies and randomized controlled trials have demonstrated that argon laser endoscopic hemostasis is both safe and efficient. Specific guidelines for successful endoscopic hemostasis have been determined. The limitations of the argon laser for emergency hemostasis are a strong absorption by blood, its expense and lack of portability, the inability to tamponade or to treat tangentially, and the vaporization potential. The Nd:YAG laser shares all these limitations except that it is less absorbed by blood. Because of these limitations, GI lasers are at present being used less for emergency hemostasis than for elective tumor ablation. Some new, non-laser, thermal devices which do not have these limitations have been developed. They are currently being evaluated in randomized trials. Perhaps because of these factors, the good results obtained with lasers for emergency hemostasis of bleeding ulcers have not been translated into clinical practice at most hospitals.
Is general practice really so bad?
Authors: R. Gatenby
Journal: BMJ (2002)

The medical press paints a depressing picture of general practice. Apparently we GPs are a dying species, demoralised, burnt out, undervalued by the public and secondary care doctors alike.

It appears that the image of poor pay, ridiculously high demands from patients, and having to deal with constant trivia and mountains of paperwork is frightening medical students and young doctors away from general practice. Then there is the stress arising from the fear of ever increasing complaints and the pressures of revalidation and clinical governance.

How many doctors are made redundant or sacked? 

Can all of this really be true? Is job satisfaction no longer there? Were things really so much better 10 or 20 years ago? And is it correct that most of us would not recommend medicine to our children?

I am one of the no longer silent minority of GPs who believe that things are not as bad everywhere as it may seem. Maybe it is because I am in a small practice in a …
Loose anagen syndrome as a severity factor for trichotillomania
Authors: K-E. Thai, R.D. Sinclair
Journal: British Journal of Dermatology (2002)

Journal Article Loose anagen syndrome as a severity factor for trichotillomania Get access K‐E. Thai, K‐E. Thai Department of Medicine (Dermatology), The University of Melbourne, St Vincent's Hospital Melbourne, Fitzroy, Victoria 3065, Australia Search for other works by this author on: Oxford Academic Google Scholar R.D. Sinclair R.D. Sinclair Department of Medicine (Dermatology), The University of Melbourne, St Vincent's Hospital Melbourne, Fitzroy, Victoria 3065, Australia Dr R.D.Sinclair. E‐mail: gibsonhh@svhm.org.au Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 4, 1 October 2002, Pages 789–792, https://doi.org/10.1046/j.1365-2133.2002.04923.x Published: 01 October 2002 Article history Accepted: 24 March 2002 Published: 01 October 2002
Dysphagia: a further symptom of hypercalcaemia?
Authors: R J Grieve, P F Dixon
Journal: BMJ (1983)

Effect of inhaled saline, sodium cromoglycate, salbutamol, isoxsuprine, and isosorbide dinitrate on exercise inducedfall inforced expiratory volume in one second (FEV,) in seven patients.(Data before and after expressed as absolute valuies (1) and postexercise change as percentage)Baseline FEV, in 1 (SEM) Before AfterMaximal percentage fall in FEV,* (SEM) p (n = 6) Saline 2-99 (0-40) 2-95 (0-39) 31 (4-7) Saline v isoxsuprine 0-01 Salbutamol 3-01 (0-51) 3-69 (0-45) 3 (2-2) Saline v sodium cromoglycate 0-01 Sodium cromoglycate 3-15 (0-49) 3-26 (0-51) 8 (4-7) Saline v salbutamol 0-001 Isoxsuprine 3-29 (0-33) 3-41 (0-43) 15 (9-4) Isoxsuprine v sodium cromoglycate 0-2 (NS) Isoxsuprine v salbutamol 0-05 Salbutamol v sodium cromoglycate 0-01 (n =7) Saline 3-13 (0-34) 3-08 (0-45) 36-9 (4-9) Saline v isosorbide 0-05 Salbutamol 34567891011)*Maximal changes in FEV, calculated from postdrug baseline. Patients, methods, and resultsWe studied seven patients aged 14-49 years with extrinsic and reproducible exercise induced asthma.Patients taking oral or aerosol corticosteroids, anti- histamines, and anticholinergic drugs were excluded.Sodium cromoglycate and bronchodilator drugs were discontinued for 24 hours before each test.Forced expiratory volume in one second (FEV,) was recorded on a water sealed spirometer (Godart Pulmotest).Exercise test consisted in steady state running on a treadmill at submaximal work loads for up to eight minutes under controlled conditions of temperature and humidity.The study was carried out in a random single blind fashion using saline (9 g/l), sodium cromoglycate nebuliser solution (10 g/l), salbutamol nebuliser solution (5 g/l), isosorbide dinitrate (10 g/l), and isoxsuprine (5 g/l).The drugs were delivered through a Wright nebuliser driven by compressed air at 10 1/min at tidal breathing for five minutes.The estimated doses of sodium cromo- glycate, salbutamol, isosorbide dinitrate, and isoxsuprine nebulised were 12 mg, 6 mg, 12 mg, and 6 mg, respectively.Spirometry was repeated at 30 minutes after inhalation, then at 2, 5, 10, 15, and 30 minutes after exercise.The results of the tests were expressed as maximal percentage fall in FEV, from the postdrug baseline and analysed with Student's paired t test.The effects of saline, salbutamol, sodium cromoglycate, and isoxsuprine were studied in six patients and the effects of saline, salbutamol, sodium cromoglycate, and isosorbide dinitrate in seven (table).The mean baseline FEV, before drug inhalation was comparable on all days of exercise testing and no significant difference was noted.Saline, sodium cromoglycate, isox- suprine, and isosorbide dinitrate also did not affect the mean baseline FEV, significantly.As expected, salbutamol had a significant bronchodilator effect (p < 0 001).In six patients the maximal mean percentage falls in FEV, (SEM) after saline, salbutamol, sodium cromoglycate, and isoxsuprine were 31 (4.7)%, 3 (2-2)%, 8 (4-7)%, and 15 (9 4)%, respectively.The preventive
Fortnightly Review: Management of variceal haemorrhage
Authors: S G J Wiliams, D Westaby
Journal: BMJ (1994)

Variceal haemorrhage complicates the clinical course of chronic liver disease in about 30% of patients.'Mortality for the index bleed is as high as 50%,2 with a 30% mortality for subsequent recurrent bleeds.The rate of recurrent haemorrhage in those who survive the initial bleeding episode is as high as 100% over two years.
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
Authors: Kyoji Moriya, Hajime Fujie, Yoshizumi Shintani, Hiroshi Yotsuyanagi, Takeya Tsutsumi, Kotaro Ishibashi, Yoshiharu Matsuura, Satoshi Kimura, Tatsuo Miyamura, Kazuhiko Koike
Journal: Nature Medicine (1998)
Ultrasound placement of peripherally inserted central catheters (PICCs) in adults with cystic fibrosis
Authors: J. BUNTING
Journal: Thorax (2000)

Chronic Pseudomonas aeruginosa infection occurs in more than 85% of adults with cystic fibrosis. Recurrent courses of intravenous antibiotics are required to treat pulmonary exacerbations and the establishment of reliable intravenous access is necessary. Administration of multiple courses of antibiotics may require the insertion of long line or central venous catheters. Totally implanted venous devices are reserved for patients where alternative access is not feasible.1Peripherally inserted central catheters (PICCs) are increasingly used for the …
In human basophils, IL-3 selectively induces RANKL expression that is modulated by IgER-dependent and IgER-independent stimuli
Authors: C. Huber, A. Odermatt, B. Hagmann, C. A. Dahinden, M. Fux
Journal: Allergy (2014)

Background Receptor activator of NF-κB ligand (RANKL) is expressed as either surface (hRANKL1, hRANKL2) or soluble (hRANKL3) form. RANKL is involved in multifaceted processes of immunoregulation and bone resorption such as they occur in rheumatoid arthritis (RA). Interestingly, activated basophils, which are effector cells in allergic inflammation, contribute to the progress of collagen-induced arthritis (CIA), a mouse model for RA. Here, we investigate under which conditions human basophils express RANKL. Methods Among other stimuli, basophils were cultured with IL-3 alone. Alternatively, as a secondary stimulus, IgER-dependent or IgER-independent agents were added simultaneously either with IL-3 or after prolonged IL-3 culturing. Expression of RANKL protein and mRNA was analyzed by flow cytometry, ELISA, and real-time PCR. A coculture system was applied to investigate biological activity of basophil-derived RANKL. Results We show that in human basophils, IL-3 but no other stimulus induces de novo expression of soluble and surface RANKL, of which the latter enhances survival of MoDC. Upon simultaneous stimulation, IgER cross-linking reduces surface RANKL expression, while IgER-independent stimuli have no effect. This is in contrast to consecutive stimulation, as triggering with both IgER-dependent and IgER-independent stimuli enhances RANKL expression, particularly in its soluble form. Real-time PCR analysis shows that RANKL expression is mainly regulated at the mRNA level. Conclusion This study identifies IL-3 as a potent inducer of RANKL expression in human basophils, suggesting them to interact with bone physiology and activation of immune cells. IgER-dependent and IgER-independent stimuli modulate the IL-3-mediated RANKL expression in a time- and stimulus-dependent fashion.
TREATMENT OF SEVERE WEIGHT LOSS WITH METHANDROSTENOLONE—A LESS VIRILIZING ANABOLIC AGENT
Authors: DUNCAN R. MACMASTER, KHOSROW ALAMIN
Journal: American Journal of Psychiatry (1963)

Forty-seven mentally disturbed, severely underweight female patients, ranging in age from 15 to 86 years, were treated for an average of 45.55 days with the anabolic agent, methandrostenolone. All patients showed an increase in weight for a group average of 7.81 pounds. The most adequate dosage consisted of 5 mg. tablets administered b.i.d. One young adolescent patient, 15 years of age, developed a slight acne, some hirsutism and menorrhagia. Three patients (6.3%) became amenorrheic. Five patients (10.6%) had reduced menses. There were no changes in pulse or blood pressure. In this series there were no voice changes or jaundice. The gain in weight, improvement in feeling of well-being and increased appetite engendered an improved psychological attitude and a greater interest in daily activities.
Seronegative Secondary Syphilis in a Patient Infected with the Human Immunodeficiency Virus (HIV) with Kaposi Sarcoma
Authors: CHARLES B. HICKS
Journal: Annals of Internal Medicine (1987)

Reagin and treponemal antibody tests are highly reliable in diagnosing secondary syphilis. However, patients infected with the human immunodeficiency virus (HIV) respond abnormally to antigenic stimulation and may fail to develop typical serologic responses to infections. We report the case of an HIV-infected man with Kaposi sarcoma and secondary syphilis whose VDRL test and fluorescent treponemal antibody-absorbed test were repeatedly nonreactive. Correct diagnosis required biopsy of a skin lesion with silver staining to show spirochetes. Clinicians treating HIV-infected patients should be aware of the problems of serologic diagnosis of syphilis in these patients. Biopsy samples of appropriate tissues and staining for spirochetes may be needed to arrive at the correct diagnosis.
Vitamin E Supplementation, Cardiovascular Events, and Cancer—Reply
Authors: Eva Lonn
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aseptic Intestinal Decompression during Surgery
Authors: John O'L. Nolan, George C. Finley
Journal: New England Journal of Medicine (1950)

THE problem of handling distended loops of bowel has plagued the medical profession for centuries, and it has only been in recent years that a satisfactory solution has been found. With the use of different tubes to decompress the stomach and occasionally the proximal duodenum much upper abdominal distention has been brought under control, and, with the Miller-Abbott and Cantor tubes, in the past ten years control of the intestine has been extended all the way down to the obstructing lesion. The results of the conservative treatment of intestinal obstruction have been most gratifying in restoring physiologic balance in dyspneic, . . .
A CASE OF GASTROTOMY FOR THE REMOVAL OF HAIR-BALL—RECOVERY.
Authors: WM. L. ALLEN
Journal: JAMA (1896)

The case I report is not only unique as regards the character of the foreign body found, but instructive from a physiologic standpoint, showing as it does the remarkable ability of the stomach to digest food in sufficient amount to maintain a fair degree of health, even under the most trying conditions. <h3>Case.</h3> —Maggie Heinz, aged 16, was brought to me in November last by Dr. De Armand. She stated that she had felt a tumor in the region of the stomach for the past six months; felt more or less pain after eating, vomited frequently, lost weight during the last twelve months and had frequent attacks of diarrhea followed by constipation. Further questioning elicited very little history that would throw light upon the case. Examination revealed a tumor in the epigastric region, oval in form and movable several inches to the right or left; it was as hard as
Gene and domain duplication in the chordate Otx gene family: insights from amphioxus Otx
Authors: N. A. Williams, P. W. Holland
Journal: Molecular Biology and Evolution (1998)

We report the genomic organization and deduced protein sequence of a cephalochordate member of the Otx homeobox gene family (AmphiOtx) and show its probable single-copy state in the genome. We also present molecular phylogenetic analysis indicating that there was single ancestral Otx gene in the first chordates which was duplicated in the vertebrate lineage after it had split from the lineage leading to the cephalochordates. Duplication of a C-terminal protein domain has occurred specifically in the vertebrate lineage, strengthening the case for a single Otx gene in an ancestral chordate whose gene structure has been retained in an extant cephalochordate. Comparative analysis of protein sequences and published gene expression patterns suggest that the ancestral chordate Otx gene had roles in patterning the anterior mesendoderm and central nervous system. These roles were elaborated following Otx gene duplication in vertebrates, accompanied by regulatory and structural divergence, particularly of Otx1 descendant genes.
Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors
Authors: Knut Stieger, Guylène Le Meur, Françoise Lasne, Michel Weber, Jack-Yves Deschamps, Delphine Nivard, Alexandra Mendes-Madeira, Nathalie Provost, Laurent Martin, Philippe Moullier, Fabienne Rolling
Journal: Molecular Therapy (2006)

Adeno-associated viral gene therapy has shown promise for the treatment of inherited and acquired retinal disorders. In most applications, regulation of expression is a critical concern for both safety and efficacy. The purpose of our study was to evaluate the ability of the tetracycline-regulatable system to establish long-term transgene regulation in the retina of nonhuman primates. Three rAAV vectors expressing the tetracycline-dependent transactivator (rtTA) under the control of either the ubiquitous CAG promoter or the specific RPE65 promoter (AAV2/5.CAG.TetOn.epo, AAV2/4.CAG.TetOn.epo, and AAV2/4.RPE65.TetOn.epo) were generated and administered subretinally to seven macaques. We demonstrated that repeated inductions of transgene expression in the nonhuman primate retina can be achieved using a Tet-inducible system via rAAV vector administration over a long period (2.5 years). Maximum erythropoietin (EPO) secretion in the anterior chamber depends upon the rAAV serotype and the nature of the promoter driving rtTA expression. We observed that the EPO isoforms produced in the retina differ from one another based on the transduced cell type of origin within the retina and also differ from both the physiological EPO isoforms and the isoforms produced by AAV-transduced skeletal muscle.
The progressive systemic sclerosis/systemic lupus overlap: an unusual clinical progression.
Authors: R A Asherson, H Angus, J A Mathews, O Meyers, G R Hughes
Journal: Annals of the Rheumatic Diseases (1991)

Three patients with the unusual combinations of discoid lupus, systemic lupus erythematosus (SLE), and progressive systemic sclerosis (PSS) are reported. The first patient developed PSS eight years after a diagnosis of discoid lupus had been made and this was complicated by myositis six years later. The second patient developed PSS more than 20 years after being diagnosed as having SLE. The third patient developed SLE with predominant features of urticarial vasculitis six years after PSS. Mild myositis also ensued. There were no antibodies to U1RNP demonstrable in any of these patients. The clinical progression of SLE to PSS or vice versa in the absence of features of mixed connective tissue disease is distinctly uncommon.
Histidine‐rich glycoprotein and changes in the components of the fibrinolytic system after streptokinase therapy in patients with pulmonary thromboembolism
Authors: Lawrence Tim Goodnough, Hidehiko Saito, William R. Bell, N. Heimburger
Journal: American Journal of Hematology (1985)

Abstract Although the biological function of histidine‐rich glycoprotein (HRG) is unknown, it may serve as an antifibrinolytic agent by interfering with the binding of plasminogen to fibrin. To define the role of HRG, plasma titers were measured by single radial immunodiffusion in eleven patients with thromboembolism before and after streptokinase (SK) therapy and were found unchanged (84.7 ± 6.2%, M ± SEM before, and 99.5 ± 6.3% after 12 hr of SK therapy). The HRG peaks on crossed immunoelectrophoresis before and after SK infusion were also unchanged. α 2 ‐plasmin inhibitor fell during SK infusion as measured immunologically (102.0 ± 15.0% before and 28.0 ± 1.6% after 12 hr of therapy) and fibrinogen‐fibrin degradative products appeared (mean titer of 1:2, 048 after 12 hr of therapy), indicating that the infused SK was biologically active. Plasminogen levels before therapy were normal, as measured functionally and immunologically (105.4 ± 4.9% and 96.0 ± 5.6%, respectively), and both decreased after 12 hr of SK therapy (15.2 ± 5.6% and 50.8 ± 4.3%). No changes in functional antithrombin III titer, Hageman factor antigen level, or fibrinogen concentration, as measured turbidimetrically, were observed. Thus, although these data do not allow one to make any firm conclusions regarding the physiologic role of this protein in fibrinolysis, they do not exclude its increased catabolism, compensated by increased production, in patients undergoing fibrinolytic therapy.
Who will care for us when we are old?
Authors: Tessa Richards
Journal: BMJ (2010)

Europe joins the global debate on who should deliver tomorrow’s health care



The phrase “Don’t waste a good crisis” has become something of a political leitmotiv in the past two years—a backdrop to proposals for reform in many spheres, not least health care.

Currently the “crisis in the health workforce” is being seen as an opportunity to radically rethink the way that health professionals are educated and trained. Prominent among the advocates for change is the Global Commission on Education of Health Professionals for the 21st Century, which is shortly to publish its blueprint to develop a new generation of health workers (www.globalcommehp.com).

In poor countries the shortage of health professionals, particularly skilled ones, is acknowledged to be a critical constraint to progress towards achieving the United Nations’ millennium development goals. But what about Europe?

Here the “crisis” pales by comparison, but all countries have serious concerns. Some, Hungary and Romania among them, report that the migration of skilled staff has left them unable to keep certain essential services staffed.

Dealing with current workforce problems is hard enough. Predicting future ones and devising …
THE TREATMENT OF TUBERCULOSIS OF THE LUNGS BY SANOCRYSIN
Authors: W. Stobie, S. Hunter
Journal: BMJ (1929)

l1 these n-otes we donot pr opose to say anythinig onl the history of sanoerysin since its introduction by Moellgaard in 1923.The stoiy of its discovery, with the eairlymetlhod of its emplov mielt and subsequentmodification, is readily available in tho niow extensive literature.Our purpose is to r-elate our experience of its use in 45 cases during the lpast two years, with special reference to themost suitable type of case for treatmenit, the dosage and length of treat- inent, and to give our' conclusions as to its value as a tllera- peutic agent in pulmoinar-y tubeirculosis.As the various complications ar'einow so well recognized they are mer ely mentioned in passing.In all cases tubercle bacilli wer e presenit in the sl)utum at the beginning of treatmenit.This point is stressed silnce so often various treatmeiits have been apparently success-
Recommendations for Implementation of Community Consultation and Public Disclosure Under the Food and Drug Administration’s “Exception From Informed Consent Requirements for Emergency Research”
Authors: Henry Halperin, Norman Paradis, Vincent Mosesso, Graham Nichol, Michael Sayre, Joseph P. Ornato, Michael Gerardi, Vinay M. Nadkarni, Robert Berg, Lance Becker, Mark Siegler, Megan Collins, Charles B. Cairns, Michelle H. Biros, Terry Vanden Hoek, Mary Ann Peberdy
Journal: Circulation (2007)