tbuckley/cabot-search huggingface dataset:
Granulocytes in Felty's Syndrome
Authors: RICHARD M. HANSEN
Journal: Annals of Internal Medicine (1977)

Comments and Corrections1 March 1977Granulocytes in Felty's SyndromeRICHARD M. HANSEN, M.D.RICHARD M. HANSEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-3-362_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Dr. Logue (1) showing elevated levels of neutrophil-bound immunoglobulin G (IgG) in Felty's Syndrome is interesting, but his conclusion that "quantitation of granulocyte-bound IgG appears to be useful in defining patients with immunologically mediated granulocytopenia" is ill founded. The patient he described did have lessening of his granulocytebound IgG postsplenectomy but he remained significantly neutropenic in spite of it. Therefore, attributing a cause and effect relation between neutropenia and granulocytebound IgG is inappropriate.The author admits that the membrane-bound IgG does not prove granulocyte antigen specificity and speculates that this could rather be...References1. LOGUE G: Felty's syndrome: granulocyte-bound immunoglobulin G and splenectomy. Ann Intern Med 85:437-442, 1976 LinkGoogle Scholar2. TURNERSCHUMACHERMYERS RRA: Phagocytic function of polymorphonuclear leucocytes in rheumatic diseases. J Clin Invest 52:1632-1635, 1973 CrossrefMedlineGoogle Scholar3. MOWATBAUM AJ: Chemotaxis of polymorphonuclear leucocytes from patients with rheumatoid arthritis. J Clin Invest 50: 2541-2549, 1971 CrossrefMedlineGoogle Scholar4. ANDREISHURDZIFF MEM: Comparison of the presence of immune complexes in Felty's syndrome and rheumatoid arthritis (RA) (abstract). Arthritis Rheum 18:383, 1975 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD M. HANSEN, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChronische Polyarthritis und Felty-Syndrom 1 March 1977Volume 86, Issue 3Page: 362-363KeywordsAntigensFelty syndromeGranulocytesNeutropeniaSpecificity ePublished: 1 December 2008 Issue Published: 1 March 1977 PDF downloadLoading ...
Expansion of acute myocardial infarction: its relationship to infarct morphology in a canine model.
Authors: L W Eaton, B H Bulkley
Journal: Circulation Research (1981)

Regional dilation (expansion) of newly infarcted myocardium has been associated with increased mortality.To study this entity further, and to define the relationship of expansion to infarct morphology, infarcts were created in 44 open-chest dogs by a coronary ligation and coronary embolization method.Twenty-one transmural and 18 nontrangmural infarcta of 1 to 11 days of age were studied.Infarct expansion was quantified by comparison of lengths of infarct and noninfarct containing segments of transversely sliced hearts.Five dogs died less than 6 hours after infarction and showed no evidence of expansion.Of those surviving more than 24 hours, 17 had infarct expansion and 22 did not.In the latter group, four infarcts were transmural and 18 were nontansmural; in the former, all 17 infarcts with expansion were transmuraL Infarct thinning for the 17 infarcts with expansion was significantly greater than that observed in the nontransmura) infarcta or the nonexpanded transmural infarcts (P < 0.001).Of the 21 transmural infarcts, the largest infarct without expansion was 10.8%, and the smallest infarct with expansion was 11.3% of left ventricular weight.Among infarcts with expansion, there was a poor correlation between the extent of expansion and infarct size (r = 0.19).A significant inverse relationship (P<0.02) was observed, however, between the extent of expansion and postinfarct survival for the transmural infarcts.Although infarct expansion occurred only in transmural infarcts exceeding a critical but relatively small threshold of injury, the absence of a further relationship between transmural infarct size and extent of expansion suggests that other anatomic, metabolic, or hemodynamic factors affect the development of acute infarct expansion.Ore Res 49: 80-88, 19S1
Probabilistic Modeling of Dietary Arsenic Exposure and Dose and Evaluation with 2003–2004 NHANES Data
Authors: Jianping Xue, Valerie Zartarian, Sheng-Wei Wang, Shi V. Liu, Panos Georgopoulos
Journal: Environmental Health Perspectives (2009)

Dietary exposure from food to toxic inorganic arsenic (iAs) in the general U.S. population has not been well studied.The goal of this research was to quantify dietary As exposure and analyze the major contributors to total As (tAs) and iAs. Another objective was to compare model predictions with observed data.Probabilistic exposure modeling for dietary As was conducted with the Stochastic Human Exposure and Dose Simulation Dietary (SHEDS-Dietary) model, based on data from the National Health and Nutrition Examination Survey. The dose modeling was conducted by combining the SHEDS-Dietary model with the MENTOR-3P (Modeling ENvironment for TOtal Risk with Physiologically Based Pharmacokinetic Modeling for Populations) system. Model evaluation was conducted via comparing exposure and dose-modeling predictions against duplicate diet data and biomarker measurements, respectively, for the same individuals.The mean modeled tAs exposure from food is 0.38 microg/kg/day, which is approximately 14 times higher than the mean As exposures from the drinking water. The mean iAs exposure from food is 0.05 microg/kg/day (1.96 microg/day), which is approximately two times higher than the mean iAs exposures from the drinking water. The modeled exposure and dose estimates matched well with the duplicate diet data and measured As biomarkers. The major food contributors to iAs exposure were the following: vegetables (24%); fruit juices and fruits (18%); rice (17%); beer and wine (12%); and flour, corn, and wheat (11%). Approximately 10% of tAs exposure from foods is the toxic iAs form.The general U.S. population may be exposed to tAs and iAs more from eating some foods than from drinking water. In addition, this model evaluation effort provides more confidence in the exposure assessment tools used.
The Prevalence of Alcoholism Among General Hospital Ward Patients
Authors: RAMNIK BARCHHA, MARK A. STEWART, SAMUEL B. GUZE
Journal: American Journal of Psychiatry (1968)

A systematic survey of consecutive admissions to the general medical wards of a large metropolitan teaching hospital revealed a high rate of alcoholism, although approximately one-third of the patients with alcoholism appeared to be in remission. Illness patterns of alcoholic patients differed from those of nonalcoholic patients. However, physicians and staff caring for these patients generally did not recognize the alcoholism.
Lipolytic Effects of B-Type Natriuretic Peptide1–32 in Adipose Tissue of Heart Failure Patients Compared With Healthy Controls
Authors: Jan Polak, Martin Kotrc, Zuzana Wedellova, Antonin Jabor, Ivan Malek, Josef Kautzner, Ludmila Kazdova, Vojtech Melenovsky
Journal: Journal of the American College of Cardiology (2011)
Abstract 960: Ceramide-dependent release of nanovesicles is a class effect oflipid-based Akt inhibitors
Authors: Joell J. Gills, Chunyu Zhang, Mones S. Abu-Asab, S. Sianna Castillo, Caleb Marceau, Alan Kozikowski, Maria Tsokos, Tzipora Goldkorn, Phillip A. Dennis
Journal: Cancer Research (2011)

Abstract Akt regulates many cellular processes and Akt inhibitors are being developed as cancer therapeutics. The mechanism of action of lipid-based Akt inhibitors (LBAIs) such as perifosine and phosphatidylinositol ether lipid analogues (PIAs) is incompletely understood. Here, we show that LBAIs quickly deplete cells of proteins such as EGFR, IGFR and p-Akt that can be recovered in tetraspanin-enriched 100,000 xg pellets from conditioned media. Electron micrographs of these pellets exhibited heterogenous vesicular structures whose diameter was less than 1 µM. In vitro, LBAI treatment increased vesicle shedding as revealed by live cell microscopy. In vivo, LBAIs increased plasma levels of nanovesicles derived from tumor xenografts. Several lines of evidence show that release of nanovesicles by LBAI depends upon ceramide generation. LBAIs increased levels of cellular ceramide, and addition of exogenous ceramide stimulated nanovesicle release. GW4869, an inhibitor of sphingomyelinase, an enzyme that generates ceramide by cleavage of sphingomyelin, blocked release of nanovesicles induced by LBAI. When transferred in vitro, purified nanovesicles increased ceramide levels and inhibited proliferation of naïve recipient cells, suggesting these contain residual LBAIs. Pre-treatment with GW4869 blocked ceramide induction in recipient cells and yielded greater retention of the donor nanovesicles. These studies identify ceramide-dependent release of cellular nanovesicles as a class effect of LBAI and a novel means to shed EGFR, IGF-IR and p-Akt from tumors that could perpetuate the cytotoxicity of LBAIs. We believe this is the first report of secondary pharmacologic effects via cell-mediated drug transfer in nanovesicles. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 960. doi:10.1158/1538-7445.AM2011-960
Sexual Violence and Armed Conflict
Authors: Lindsay Stark
Journal: JAMA (2011)

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When managers rule
Authors: B. Jarman
Journal: BMJ (2012)

Patients may suffer, and they’re the ones who matter

Written by the managing director of Sainsbury’s supermarkets, and three other businessmen, the “Griffiths report” (1983)1 unleashed a management revolution in the NHS. The report’s key recommendation were for a supervisory board to overview policy and strategy and a management board to implement it, together with regional, district, and unit general managers. In 2008, with the revolution well and truly over, the Health Service Journal ranked Roy Griffiths 12th in its list of the 60 most influential people in the NHS’s history for his role in setting NHS management on its current path.

After the report’s publication, the administrator of our district management team said something like “we will run the show from now on.” This was despite Griffiths’ recommendation that, consistent with clinical freedom for clinical practice, clinicians should be involved more closely in management and participate fully in spending decisions. At the time, Manfred Davidmann, who comments on styles of management, put his finger on one of the report’s problems: “What is completely missing from the inquiry team is grass-roots representation of any kind from all those who would be affected by the inquiry’s findings, namely from doctors, nurses . . .” He also correctly predicted how the new “managerialism” would play out over the next 30 years: “Management (that is executives) are apparently to provide patients and the community with what management and higher authority think is good for them.”2

My contention is that the imbalance between the power of managers and doctors, which Griffiths …
Scintigraphic Assessment of Perivesical Urinary Extravasation Following Renal Transplantation
Authors: DAVID L. BUSHNELL, DOUGLAS G. WILSON, LIONEL M. LIEBERMAN
Journal: Clinical Nuclear Medicine (1984)

Radionuclide scintigraphy is a safe and accurate means of detecting postoperative urologic complications in renal transplant recipients. Early identification of urinary leakage coupled with aggressive intervention significantly reduces the associated morbidity and mortality. Perivesical extravasate may be difficult to distinguish from adjacent or nearby bladder activity on scintiscan. Clarification of actual bladder contour and determination of its exact location within the pelvis may resolve such uncertainties. We describe imaging techniques that define the anatomic extent of the bladder and demonstrate our scintigraphic assessment of perivesical extravasation.
Hydrogen peroxide, an inhibitor of platelet function: Effect on adenine nucleotide metabolism, and the release reaction
Authors: Marie J. Stuart, Holm Holmsen
Journal: American Journal of Hematology (1977)

Abstract The in vitro effects of H 2 O 2 on platelet adenine nucleotide metabolism and on the ADP‐induced platelet release reaction were examined. All studies were performed on human platelet‐rich plasma (PRP) preincubated with ( 3 H)‐adenine. Within 3 min of incubation with PRP, H 2 O 2 (100–500 μM) caused an irreversible reduction in the ( 3 H)‐ATP level with a concomitant increase in ( 3 H)‐IMP and ( 3 H)‐inosine and hypoxanthine levels. The adenylate energy charge (AEC) initially decreased while the ATP level fell. The AEC, however, returned to levels slightly lower than the control during further incubation. No leakage of ATP and ADP to plasma was observed. The fall in the steady‐state levels of ( 3 H)‐ATP increased with increase of the H 2 O 2 concentration (decrease of 8.7–40% at H 2 O 2 concentrations from 5 to 600 μM). H 2 O 2 pretreatment of PRP caused absence of ADP‐induced biphasic aggregation, partial inhibition of the primary wave, and complete inhibition of release of platelet nonmetabolic ATP and ADP. Our in vitro findings support the view that part of the inhibitory effect of H 2 O 2 may be related to the lowering of metabolic ATP levels in platelets.
On Becoming a Psychiatrist: 1934-1942
Authors: John Romano
Journal: JAMA (1989)

My interest in psychiatry began when I was a first-year medical student at Marquette University in Milwaukee, Wis, in 1928. The lecturer in anatomy, Walter Zeit, who later became a friend and mentor, drew my attention to the distinction between the functional and the anatomic distribution of pain, anesthesia, and paralysis in the extremities of patients with hysterical disorders, in contrast to those with cerebral vascular lesions and those with peripheral nerve and nervecord injuries. This led me to read several case histories of hysterical patients. Later, as a clinical student and intern, I had full opportunity to become acquainted with acutely and chronically ill psychiatric patients as I became responsible for their care on admission to the emergency and detention floors of a large county hospital. I also became familiar with the gamut of traditional neurotic symptomatology seen in patients throughout the hospital and in the outpatient clinics. In
Ultrasound for the Diagnosis of Atrial Tumor
Authors: RICHARD L. POPP
Journal: Annals of Internal Medicine (1969)

The correct preoperative diagnosis of a left atrial myxoma was established using the ultrasonic cardiac echogram in this patient. The findings at cardiac catheterization and angiocardiography were not diagnostic. It is suggested that the ultrasonic cardiac echogram is a simple atraumatic method for the diagnosis of an elusive condition.
NHS Direct audited
Authors: S. George
Journal: BMJ (2002)

NHS Direct—“the gateway to the NHS.” An all singing, all dancing mega-service that will give you health advice and information when you ask for it; make sure that you receive the urgent care you need but did not realise you did; stop you demanding care you did not need by encouraging you to undertake self care, or by diverting you to a more appropriate source of care if you cannot manage by yourself; find you a dentist or a pharmacy open outside shop hours; and will soon be able to book you your appointment with your general practitioner, remind you of your hospital appointment, and… the list goes on. NHS Direct, the telephone health advice and information line is nearly four years old.1 How is it performing?

Three NHS Direct pilot sites were launched in March 1998 and the service now covers all of England. …
The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.
Authors: J Bill, O Kanagawa, D L Woodland, E Palmer
Journal: The Journal of Experimental Medicine (1989)

We have generated an mAb, RR3-15, that recognizes murine TCRs containing the V beta 11 domain. Using this antibody to stain peripheral T cells, we have demonstrated that V beta 11-bearing T cells are largely absent from strains of mice that express the class II MHC molecule, I-E. Studies with F1 mice demonstrate that this effect is dominant, consistent with tolerance. The clonal deletion of V beta 11-bearing T cells appears to occur intrathymically, as immature but not mature V beta 11+ T cells are present in the thymus of I-E-bearing mice. Examination of B6 x DBA/2 recombinant inbred strains demonstrates that the expression of I-E molecules is necessary for the clonal deletion of V beta 11-bearing T cells, but that other non-MHC genes control the clonal deletion process, as well. Paradoxically, only a small fraction of V beta 11+ T cell hybridomas are I-E reactive.
Heart-sound screening in children. Use of a portable analog-digital computer (field study--Los Angeles 1966)
Authors: R. E. Durnin
Journal: JAMA (1968)

The heart sounds of 3,797 school children were analyzed by a new portable analog-digital computer. A small microphone and bipolar electrocardiographic timing leads are the only inputs required from the patient. Heart sounds are analyzed on a beat-by-beat basis. The data are displayed on digital counters and are recorded as within normal limits (WNL) or outside normal limits (ONL) of the computer's programmed analyzing circuitry. Eighteen percent of the 3,797 students were examined by pediatric cardiologists. Sixteen cases of heart disease and two cases of conduction disturbances were detected by the computer. Half of the heart disease cases were previously unknown. No known cases of heart disease were missed by the computer. The false-positive ratio was 5.6%. Immediate analysis of heart sounds offers advantages over the tape-recording method of screening.
Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma.
Authors: H Saito, S J Scialla
Journal: Journal of Clinical Investigation (1981)

We have previously described two unrelated individuals with homozygous Hageman trait (Factor XII deficiency) whose plasmas contained nonfunctional material immunologically indistinguishable from normal Hageman factor (HF). Abnormal HF from the plasma of one these subjects has now been purified to homogeneity, as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, alkaline disc gel electrophoresis, and immunoelectrophoresis. Purified abnormal HF had no clot-promoting activity, but showed the same specific antigenicity as purified normal HF by an immunoassay. The abnormal HF was of a single chain polypeptide with the same molecular weight (80,000) as normal HF and was positively stained by periodic acid-Schiff reagent. Both normal and abnormal HF had similar amino acid compositions and isoelectric points (pI 6.5 approximately 7.1). When 125I-labeled abnormal HF and 131I-labeled normal HF were mixed with normal plasma and exposed to glass, both HF underwent an identical pattern of cleavage, yielding 52,000- and 30,000-mol wt fragments. Similarly, abnormal HF was fragmented by trypsin in the same way as normal HF, but no prekallikrein-activating activity was generated after cleavage. [3H]Diisopropyl phosphorofluoridate was incorporated into a 29,000-mol wt fragment of the trypsin-cleaved normal HF, but not into that of the trypsin-cleaved abnormal HF. These data suggest that the molecular defect in this abnormal HF resides at or near the active site serine residue in the 30,000-mol wt part of the molecule.
Physiologic Jaundice: The Enterohepatic Circulation of Bilirubin
Authors: Ronald L. Poland, Gerard B. Odell
Journal: New England Journal of Medicine (1971)

Abstract To evaluate the role of the enterohepatic circulation of bilirubin in  hyperbilirubinemia, nine full-term infants delivered by cesarean section were given a formula supplemented with agar for the first five days of life starting at the 20th hour. Agar stabilizes bilirubin in aqueous solution and prevents its bacterial conversion. Ten infants were given the same formula without agar. No rise in the serum bilirubin concentration occurred after the 13th hour of life in the agar-fed infants. More bilirubin was excreted in the feces within the first five days in infants fed formula with agar, and these infants also lost less weight than the controls. By the sixth day, total fecal bilirubin excretion from birth was similar in both groups. These results suggest that the reabsorption of bilirubin from the intestine can be a major cause of neonatal physiologic jaundice.
The Many Faces of Lupus Erythematosus
Authors: Frederick A. J. Kingery
Journal: JAMA (1966)

The "butterfly" rash over the nose and cheeks in lupus erythematosus (LE) is probably the best-known example of a cutaneous lesion heralding a systemic disease. This sign is so well established in every physician's mind that (1) the butterfly eruptions of seborrheic dermatitis, rosacea, or erysipelas are commonly misdiagnosed as LE lesions, and (2) LE lesions which occur in other distribution patterns may go unrecognized. The biopsy specimen from a lesion in question will usually differentiate lupus erythematosus from other cutaneous disorders. The clinician, however, can at times make a presumptive diagnosis if he looks closely at the distinctive morphologic appearance of the lesion. Lupus erythematosus often has no cutaneous expression. Skin lesions also may be nonspecific in character, but, frequently, features which accurately identify the disease can be recognized. Specific lesions are characterized by an adherent dry scale with evidence of follicular plugging, by a dusky erythema, and by
Angiotensin converting enzyme inhibitors and asthma
Authors: W H W Inman, L Wilton, G Pearce, R D Mann
Journal: BMJ (1994)

EDITOR, - Helen Lunde and colleagues have reported a potential hazard of angiotensin converting enzyme inhibitors.1 They concluded, from 36 spontaneous reports of asthma, bronchospasm, or dyspnoea received by the Swedish Adverse Drug Reactions Committee and 834 received by the World Health Organisation's monitoring centre, that symptoms of airway obstruction might be a rare but potentially serious reaction to this group of drugs. They calculated that there might have been one report in Sweden for every 6200 new prescriptions but accepted that such an estimate, based on anecdotal reports, is speculative.

We have compared data from prescription event monitoring studies of 29 170 patients treated with enalapril, lisinopril, or …