tbuckley/cabot-search huggingface dataset:
MONILIAL GRANULOMA TREATED BY AMPHOTERICIN B IN AN ACHONDROPLASTIC WITH BRONCHIECTASIS.
Authors: F. F. HELLIER, C. J. LA TOUCHE, N. R. ROWELL
Journal: British Journal of Dermatology (1963)

Journal Article MONILIAL GRANULOMA TREATED BY AMPHOTERICIN B IN AN ACHONDROPLASTIC WITH BRONCHIECTASIS. Get access F. F. HELLIER, F. F. HELLIER Leeds General Infirmary Search for other works by this author on: Oxford Academic Google Scholar C. J. LA TOUCHE, C. J. LA TOUCHE Leeds General Infirmary Search for other works by this author on: Oxford Academic Google Scholar N. R. ROWELL N. R. ROWELL Leeds General Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 10, 1 October 1963, Pages 375–381, https://doi.org/10.1111/j.1365-2133.1963.tb13915.x Published: 01 October 1963
Evaluation of nocturnal bronchoconstriction by all night tracheal sound monitoring.
Authors: C. Lenclud, G. Cuttitta, D. Van Gansbeke, A. Visconti, A. Van Muylem, V. Bellia, J. C. Yernault
Journal: Thorax (1996)

BACKGROUND: A study was undertaken to evaluate the reliability of a digital tracheal sound analyser (ELENS-DSA) in predicting nocturnal changes in airways resistance in asthmatic patients. This device allows continuous measurement of the proportion of the time occupied by wheezing (Wh%). METHODS: Nocturnal polygraphic studies with simultaneous continuous monitoring of tracheal sounds and airways resistance were performed in seven patients with nocturnal asthma. In order to evaluate the possible bias in wheezing estimation, each tracheal sound recording was passed through the automatic analyser and simultaneously monitored with earphones by an experienced observer. RESULTS: The device detected audible wheezing with an optimal sensitivity and specificity of 70%. Snoring was a minor cause of the relatively poor characteristics of the system. A close correlation (p &lt; 0.001) between Wh% and airways resistance was observed only in those patients with the highest increase in resistance; when the results of all the subjects were pooled the correlation observed was poor. The predictive value of Wh% in detecting changes in airways resistance during 10 minute intervals was lower than 70%. The positive and negative predictive values of Wh% were raised to 79% and 83%, respectively, for 30 minute intervals. CONCLUSIONS: The ELENS-DSA system is a relatively crude means of detecting wheezing and assessing bronchoconstriction quantitatively. However, it is able to detect accurately nocturnal bronchoconstriction for 30 minute intervals. This finding, along with the fact that the monitoring is non-invasive, suggests that it may be a promising tool, especially for patients during sleep.
202 HIGH MORTALITY AFTER TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT (TIPS) PLACEMENT IN LIVER TRANSPLANT RECIPIENTS
Authors: I.W. Graziadei, A. Finkenstedt, K. Nachbaur, W. Jaschke, W. Mark, R. Margreiter, W. Vogel
Journal: Journal of Hepatology (2008)
Two Cases of 18 F-FDG PET/CT Findings in Acinar Cell Carcinoma of the Pancreas
Authors: Kentaro Takanami, Keiko Abe, Atsushi Mitamura, Shukichi Miyazaki, Keiko Abe, Kazuyuki Ishida, Shogo Yamada, Shoki Takahashi
Journal: Clinical Nuclear Medicine (2009)

The patients consisted of a 60-year-old woman and a 72-year-old man with no significant symptoms, who were both referred to the hospital due to the presence of large pancreatic tumors. They underwent F-18 FDG PET/CT and subsequently a pancreaticoduodenectomy and acinar cell carcinoma in the pancreas was proven histopathologically. In one case, the tumor consisted of a solid component presenting intense FDG uptake and necrotic tissue. In another case, the tumor consisted of cystic and papillary components presenting with weak FDG uptake. This report thus documents 2 cases of acinar cell carcinoma that showed contrasting histopathologic and F-18 FDG PET/CT findings.
Perturbation of Organogenesis by the Herbicide Atrazine in the Amphibian<i>Xenopus laevis</i>
Authors: Jenny R. Lenkowski, J. Michael Reed, Lisa Deininger, Kelly A. McLaughlin
Journal: Environmental Health Perspectives (2007)

Exposure to anthropogenic chemicals during development can disrupt the morphogenesis of organ systems. Use of the herbicide atrazine has been debated in recent years because of its implicated, but poorly characterized, effects on vertebrates. Previous studies primarily examined the effects of atrazine exposure during metamorphosis or early developmental stages of amphibians.
Apple‐dependent exercise‐induced anaphylaxis
Authors: B. Añíbarro, C. Domínguez, J. M. Díaz, M. F. Martín, M. C. García‐Ara, M. T. Boyano, J. A. Ojeda
Journal: Allergy (1994)

Añíbarro B, Domínguez C, Díaz JM, Martín MF, García‐Ara MC, Boyano MT, Ojeda JA. Apple‐dependent exercise‐induced anaphylaxis.
Abstract 5577: Global analysis of protein kinase activity during hematopoietic differentiation
Authors: Tyzoon K. Nomanbhoy, Dana M. Ng, Matthew P. Patricelli
Journal: Cancer Research (2010)

Abstract Cell proliferation and differentiation are highly regulated processes, and the deregulation of these processes can lead to a number of diseases including cancer. Protein kinases are key regulators of cell proliferation and differentiation, and consequently, potential targets for a number of oncology indications. A detailed understanding of the changes in kinase activity/expression during cell proliferation and differentiation may be one of the keys to the identification of novel biomarkers and targets for the diagnosis and treatment of these diseases. The HL-60 cell line is promyeloblastic, and protocols for the differentiation of these cells into either macrophages by 12-O-tetradecanoylphorbol-13-acetate (PMA), or granulocytes by retinoic acid (RA) are well-established. Importantly, HL-60 cell differentiation is a model system for the treatment of myelocytic leukemia, and identifying the mechanisms that induce terminal differentiation of these cells may reveal effective targets for treatment of this disease. With this in mind, we evaluated the kinase activity and expression profiles of HL-60 cells throughout the differentiation process using desthiobiotin acyl phosphate ATP and ADP probes and liquid chromatography-mass spectrometry. Greater than 150 protein kinases in resting, RA, and PMA HL-60 cells were analyzed. Significant changes in activity/expression were seen for a number of protein kinases in both differentiation pathways. These changes in kinase activity were generally consistent with changes in protein expression levels, as determined by Western blot. In both RA and PMA-induced HL60 differentiation, the kinetics for the changes in activity of the kinases was determined, and the results suggest that there is a well-defined sequence during which these changes occur. In summary, using activity based protein profiling, we identified a subset of kinases whose activity changed significantly during RA and PMA-induced HL-60 differentiation. Importantly, this methodology is widely applicable to other cellular systems and disease models, and has applications in the identification of biomarkers and targets for the management of these diseases. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5577.
Association of Bullous Pemphigoid and Malignant Neoplasms
Authors: Sophie Carrie Shan Cai, John Carson Allen, Yen Loo Lim, Suat Hoon Tan, Mark Boon Yang Tang
Journal: JAMA Dermatology (2015)

We thank our colleagues and nurses, especially those in the Immunobullous Clinic, National Skin Centre
Faecal and Urinary Incontinence after Multimodality Treatment of Rectal Cancer
Authors: Marilyne M Lange, Cornelis J. H van de Velde
Journal: PLoS Medicine (2008)

Key Learning Pointscommon and can have a major impact on QOL. and abdominoperineal resection, and about their potential outcomes.development of faecal and urinary incontinence, with an additional effect of radiotherapy.radiotherapy.problems are available; conservative therapies should be the first line-choice.
Elevation of chemotactic factor inactivator in alcoholic liver disease
Authors: Richard A. Robbins, Rowen K. Zetterman, Todd J. Kendall, Gail L. Gossman, Howard P. Monsour, Stephen I. Rennard
Journal: Hepatology (1987)

Defective regulation of neutrophil chemotaxis occurs in patients with alcoholic liver disease. One potent mediator of neutrophil chemotaxis is the complement-derived neutrophil chemoattractant, C5a, which can be inhibited by a serum protein, chemotactic factor inactivator. We hypothesized that chemotactic factor inactivator elevation might, in part, explain the defective neutrophil chemotaxis seen in patients with alcoholic hepatitis. To test this hypothesis, sera were collected from 22 patients with alcoholic hepatitis and 9 normal controls, and evaluated for the antigenic presence of chemotactic factor inactivator using an ELISA test. Chemotactic factor inactivator levels were found to be markedly elevated in patients with alcoholic hepatitis (162 ± 24 μg per ml) compared to normals (60 ± 3 μg per ml, p &lt; 0.01). Subdividing the hepatitis patients revealed that the elevation of chemotactic factor inactivator was found to be greatest in those patients with mild alcoholic hepatitis (prothrombin time within normal limits and bilirubin ≤5 mg per dl, 256 ± 44 μg per ml, p &lt; 0.001), while the group with the severest hepatic dysfunction (prolonged prothrombin time and bilirubin &gt;5 mg per dl) did not differ significantly from controls (71 ± 11 μg/ml, p &lt; 0.2). Importantly, the inhibition of C5a-induced chemotactic activity by partially purified chemotactic factor inactivator correlated with antigenic amounts of chemotactic factor inactivator in serum (r = 0.63, p &lt; 0.05). The C5a inhibitory activity in sera obtained from patients with alcoholic hepatitis coprecipitated with chemotactic factor inactivator when serum was precipitated by ammonium sulfate precipitation (45 to 64% saturation). Depleting chemotactic factor inactivator by affinity chromatography resulted in a major loss of the ability of this partially purified chemotactic factor inactivator to inhibit C5a-induced chemotaxis (50 vs. 26% inhibition, p &lt; 0.001), suggesting that chemotactic factor inactivator is a major inhibitor of C5a in these patients. These data suggest that elevations in chemotactic factor inactivator may explain impaired neutrophil chemotaxis in patients with alcoholic hepatitis.
Lead exchange in teeth and bone--a pilot study using stable lead isotopes.
Authors: B L Gulson, B R Gillings
Journal: Environmental Health Perspectives (1997)

Stable lead isotopes and lead concentrations were measured in the enamel and dentine of permanent (n = 37) and deciduous teeth (n = 14) from 47 European immigrants to Australia to determine whether lead exchange occurs in teeth and how it relates to lead exchange in bone. Enamel exhibits no exchange of its European-origin lead with lead from the Australian environment. In contrast, dentine lead exchanges with Australian lead to the extent of approximately 1% per year. In one subject, trabecular bone from the tooth socket exchanged almost all its European lead with Australian lead over a a 15-year period (turnover of approximately 6% per year), similar to the approximately 8% per year proposed for lead turnover in trabecular bone. The repository characteristics of intact circumpulpal dentine were investigated by analyses of four sets of contiguous slices from six teeth: 1) a set consisting of slices with intact circumpulpal dentine and cementum; 2) a set in which these areas were removed; 3) another set consisting of slices with intact circumpulpal dentine and cementum; and 4) a set without cementum. These analyses show relatively small differences in isotopic composition between contiguous slices except that circumpulpal dentine appears to be the dominant control on lead concentration. There is a significant correlation (R2 = 0.19, p = 0.01, n = 34) of dentine lead concentration and rate of exchange with residence time from the country of origin and Australian lead, but there is no such correlation with enamel lead concentration. Analyses of permanent and deciduous teeth of subjects from other countries who have resided in Australia for varying lengths of time should resolve some of the questions arising from this pilot study.
TLR9 and IRF3 Cooperate to Induce a Systemic Inflammatory Response in Mice Injected With Liposome:DNA
Authors: Wendy E Walker, Carmen J Booth, Daniel R Goldstein
Journal: Molecular Therapy (2010)

Liposome:DNA is a promising gene therapy vector. However, this vector can elicit a systemic inflammatory response syndrome (SIRS). Prior reports indicate that liposome:DNA vectors activate Toll-like receptor (TLR)9. We hypothesized that liposome:DNA vectors also activate the cytosolic DNA-sensing pathway, which signals via interferon (IFN) regulatory factor (IRF)3. To test this, we treated dendritic cells (DCs) with liposome:DNA in vitro and found that IRF3 was phosphorylated independent of TLR9. To test the contribution of this pathway in vivo, we injected a liposome:DNA vector into wild-type (WT), TLR9-knockout (KO), IRF3-KO, and TLR9-IRF3-double-KO (DKO) mice. WT mice exhibited a systemic inflammatory response, evidenced by elevations in serum cytokines, serum enzyme changes indicating organ damage, hypothermia, and mortality. The cytokine response was reduced in TLR9-KO, IRF3-KO, and TLR9-IRF3-DKO mice and all three groups survived. We found that IFN-gamma-KO mice that receive liposome:DNA had a reduced cytokine response and 100% survival. CD11c(+) and NK1.1(+) cells produced IFN-gamma and depleting CD11c(+) cells reduced the cytokine response in mice injected with liposome:DNA. These findings may facilitate the development of immunologically inert gene therapy vectors and may provide general insight into the mechanisms of SIRS.
Genetic Damage From Diagnostic Radiation
Authors: Irwin D. J. Bross
Journal: JAMA (1977)

Using the data from the Tri-State Leukemia Survey and a mathematical model, the hypothesis that low levels of diagnostic radiation produce severe genetic damage that is expressed in the child of the exposed person as leukemia and other diseases is tested. It is estimated that for about 1% of the exposed persons who are affected by radiation, there is a 50-fold increase in the risk of leukemia and a five-fold increase in certain other diseases. (<i>JAMA</i>237:2399-2401, 1977)
Mumps cases on the rise in England and Wales
Authors: Roger Dobson
Journal: BMJ (2005)

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Students queue to receive vaccination against measles, mumps, and rubella at Lancaster Univerity's health centre 

Credit: LANCASTER GUARDIAN

Reported new cases of mumps in England and Wales for January are more than 13 times higher than for the same period last year and are currently …

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POLYUNSATURATED FATTY ACIDS AND OMEGA-3 AS PREDICTORS OF MORTALITY IN DEPRESSED HEART FAILURE (HF) PATIENTS
Authors: Mona Fiuzat, Wei Jiang, Harry Oken, Linda Shaw, Maragatha Kuchibhatla, Michael Cuffe, Shelby Ladd, Ranga Krishnan, Christopher O’Connor
Journal: Journal of the American College of Cardiology (2010)
Circulating antibodies against human colonic extract enriched with a 40 kDa protein in patients with ulcerative colitis.
Authors: F Takahasi, H S Shah, L S Wise, K M Das
Journal: Gut (1990)

We have previously described a 40 kDa colonic protein(s) which is specifically recognised by tissue-bound immunoglobulin G obtained from the colon of patients with ulcerative colitis. We now report the presence of circulating antibodies against this antigen using an enzyme-linked immunosorbent assay with a highly enriched preparation of the 40 kDa protein from normal colon extracts. Serum was collected from 79 patients with ulcerative colitis, 36 with Crohn9s disease, 16 with specific diarrhoeal syndromes, and from 19 normal subjects. Twenty nine of 79 patients with ulcerative colitis, 21 of 36 with Crohn9s disease, and all patients with diarrhoea were symptomatic during the collection of sera. The difference in optical density values between patients with symptomatic ulcerative colitis and each of the other groups, including patients with ulcerative colitis in remission, was highly significant (p less than 0.01). Seventy nine per cent of patients with symptomatic ulcerative colitis had optical density values above the means for all other groups. Fifty five per cent of sera from patients with symptomatic ulcerative colitis had optical densities beyond two SDs of the values for all other groups and only two of 71 sera from non-ulcerative colitis patients (one Crohn9s disease and one normal subject) had values in this range. These results show the presence of anti-colon antibodies against the 40 kDa protein(s) in the sera of many patients with symptomatic ulcerative colitis.
Enzyme assays: plea for common sense.
Authors: J J Taylor
Journal: BMJ (1977)

we must challenge the rather offensive re- marks against both pathologists and coroners' officers on their attitude and lack of sympathetic communication with the bereaved.Having worked in close association with the coroners' system in south-east London and Greater London over many years we can only state that rarely does a day pass when a mem- ber of the "team" does not explain in simple language the reasons for a coroner's post- mortem and the findings-the explanation may be in terms like "furred" or "blocked" pipes in relation to infarctions, obstructions in the bowel, etc-either to the coroner's officers or the bereaved relatives.Furthermore, we know that many of our colleagues in hospital pathology and other medicolegal institutions are more than willing to speak to relatives at any time.
Endothelin-A Receptor Antagonism Reduces Blood Pressure and Increases Renal Blood Flow in Hypertensive Patients With Chronic Renal Failure
Authors: Jane Goddard, Neil R. Johnston, Malcolm F. Hand, Allan D. Cumming, Ton J. Rabelink, Andrew J. Rankin, David J. Webb
Journal: Circulation (2004)

Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade.We conducted a randomized, placebo-controlled, double-blind, 4-way crossover study comparing selective ET receptor antagonists BQ-123 (ETA) and BQ-788 (ETB), given alone and in combination, in acute studies in 8 hypertensive CRF patients and 8 matched healthy controls. BQ-123, alone and in combination with BQ-788, reduced blood pressure in CRF, particularly with BQ-123 alone (mean arterial pressure: controls -4+/-2%, CRF -13+/-2%, P<0.01 versus placebo). In CRF, in the face of this fall in blood pressure, BQ-123 substantially increased renal blood flow (38.8+/-23.9%, P<0.01 versus placebo) and reduced renal vascular resistance (-44.5+/-11.3%, P<0.01 versus placebo) when given alone but not when combined with BQ-788. These changes were accompanied by a reduction in effective filtration fraction. BQ-123, alone or in combination with BQ-788, had minimal effects on the renal circulation in healthy controls, and BQ-788 alone produced both systemic and renal vasoconstriction in CRF and healthy controls.ETA receptor antagonism was highly effective in lowering blood pressure in CRF patients currently treated for hypertension. In addition, there were effects consistent with a renoprotective action. However, because the ETB receptor appears to play a key role in the maintenance of tonic renal vasodilation, combined ETA/B receptor antagonism, although it lowered blood pressure, did not confer these renal benefits.
Failure to confirm evidence for existence of two populations with duodenal ulcer.
Authors: R J Prescott, W Sircus, C L Lai, S K Lam
Journal: BMJ (1976)

Failure to confirm evidence for existence of two populations with duodenal ulcer A previous study on 339 patients attending a gastrointestinal unit suggested that patients with duodenal ulcer could be divided into two types.1 2 The distinction was based on maximal acid secretion and apparent differences in the prevalence of several clinical features, particularly family history, bleeding and perforation, and ABO blood grouping.In a further series of two groups of 100 patients referred consecutively to the same unit, however, no such distinction could be made.The results of this further study are presented here. Methods and results
Platelet Ca2+ responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca2+ stores
Authors: C. Y. Eleanor Fung, Sarah Jones, Adwoa Ntrakwah, Khalid M. Naseem, Richard W. Farndale, Martyn P. Mahaut-Smith
Journal: Blood (2012)
Late massive haemoptyses from bronchopulmonary collaterals in infarcted segments following pulmonary embolism
Authors: CS Thomas, J Endrys, A Abul, G Cherian
Journal: European Respiratory Journal (1999)

Massive, recurrent haemoptyses requiring blood transfusions occurred in a patient who had been diagnosed as having pulmonary thromboembolism 3 months earlier. To the authors' knowledge this is the first case report of this kind, in which massive haemoptyses were proved to be caused by large bronchopulmonary collaterals that had developed in the infarcted lung segments affected by embolism. Selective embolization of the collaterals proved to be therapeutic and life saving.
Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.
Authors: M Freemark, P Driscoll, R Maaskant, A Petryk, P A Kelly
Journal: Journal of Clinical Investigation (1997)

To explore potential roles for lactogenic hormones in human fetal development, we examined the distribution and ontogenesis of expression of prolactin receptors (PRLRs) in human fetal tissues at 7.5-14 wk of gestation and in tissues of the embryonic and fetal rat on days e12.5-e20.5. Histochemical analysis of PRLR immunoreactivity in the human fetus and fetal rat revealed novel and unexpected patterns of receptor expression. Most remarkable was the appearance in early fetal development of intense PRLR immunoreactivity in tissues derived from embryonic mesoderm, including the periadrenal and perinephric mesenchyme, the pulmonary and duodenal mesenchyme, the cardiac and skeletal myocytes, and the mesenchymal precartilage and maturing chondrocytes of the endochondral craniofacial and long bones, vertebrae and ribs. Striking changes in the cellular distribution and magnitude of expression of PRLRs were noted in many tissues during development. In the fetal adrenal the initial mesenchymal PRLR expression is succeeded by the emergence of PRLR immunoreactivity in deeper fetal cortical cell layers. In the fetal kidney and lung, the invagination of cortical mesenchyme is accompanied by progressive PRLR immunoreactivity in bronchial and renal tubular epithelial cells. In the pancreas, the PRLR is expressed primarily in acinar cells and ducts in early gestation; in late gestation and in the postnatal period, the PRLR is expressed predominantly in pancreatic islets, co-localizing with insulin and glucagon. Finally in fetal hepatocytes, PRLR immunoreactivity increases significantly between embryonic days e52 and e96 in the human fetus and between days e16.5 and e18.5 in the fetal rat. In addition to playing important roles in reproduction, lactation, and immune function, the lactogenic hormones likely play roles in tissue differentiation and organ development early in gestation.