tbuckley/cabot-search huggingface dataset:
In situ hybridization analysis of CRABP II expression in sebaceous follicles from 13-cis retinoic acid-treated acne patients
Authors: J.H. SITZMANN, F.W. BAUER, W.J. CIJNLIFFE, D.B. HOLLAND, P.K. LEMOTTE
Journal: British Journal of Dermatology (1995)

The aim of this study was to investigate the effects of 13-cis retinoic acid treatment on cellular retinoic acid binding protein II (CRABP II) mRNA expression in sebaceous follicles from acne patients, using in situ hybridization. Biopsies were taken from uninvolved skin areas in close juxtaposition to inflamed comedos before therapy, and at 2–4 or 14-16 weeks of treatment. Paraffin sections were used for in situ hybridization study with riboprobes transcribed from human CRABP II cDNA. After oral treatment with l 3-cis retinoic acid, sebaceous glands were reduced in size and atrophic, and the ratio of sebum-free to fully differentiated (sebum-producing) sebocytes was dramatically increased. The CRABP II expression in the sebaceous gland, and to some extent in infundtbular structures, was strongly increased compared with the level of expression in the epidermis. The maximum signal was always found in layers of suprabasal sebocytes lacking lipid droplets. but never in the basal layers. These findings indicate a selective activity of 13-cis retinoic acid on CRABP II mRNA expression in the sebaceous glands of acne patients.
Reviews and Notes: General Practice
Authors: John F. Burnum
Journal: Annals of Internal Medicine (1995)

Literature of Medicine1 September 1995Reviews and Notes: General PracticeJohn F. Burnum, MDJohn F. Burnum, MDTuscaloosa, AL 35401.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-5-199509010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail John Murtagh. 1107 pages. New York: McGraw-Hill; 1994. $79.00. ISBN 452807-6. Order phone 800-262-4729.Although we general internists have begun to do many things formerly associated with general practice, our cachet continues to be our commitment to and pleasure in understanding the mechanisms of disease as we care for our patients. Know theory, and practice will follow. How, then, shall I respond to Murtagh's General Practice, a distillate of the pragmatic aspects of office patient care?The book begins by aptly characterizing the physician as a trusted friend of the patient, and it closes with a wrap-up of the treatment ... Author, Article, and Disclosure InformationAffiliations: Tuscaloosa, AL 35401. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1995Volume 123, Issue 5Page: 396-396KeywordsDyspneaLungsMultiple myelomaNeuromuscular diseasesObesityPatientsPrimary carePruritusPulmonary diseasesSalicylates Issue Published: 1 September 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Assessment of fitness for surgical procedures
Authors: H M C Corfield
Journal: BMJ (1980)

per se a benign condition, Dressler himself described the main complication of post- myocardial infarction syndrome as being cardiac tamponade in patients who had been prescribed anticoagulants, this being the cause of death in one member of his original series.5It also appears that prior to Dressler's original paper there were numerous reports in the literature describing haemopericardium (often fatal) in postinfarction patients on anticoagulants.Many of these appear in retrospect to have had features of the then unrecognised postmyocardial infarction syndrome.
Bone pains in chronic myelomonocytic leukaemia, treated by cytosine arabinoside.
Authors: J Asherov, Y Shoenfeld, J Pinkhas
Journal: Annals of the Rheumatic Diseases (1978)

faeces were collected at home and returned direct to our laboratory by post.Klebsiella pneumoniae was cultured from the faeces of 8 (33-3%) of the patients and 8 (30 8%) of the controls.This difference is not significant.When the results were analysed with regard to our classification of activity of their spondylitis, we found that 2 (33-3%), 5 (33 3%), and 1 (33 -3 %) of patients with definitely active, probably active, and inactive spondylitis respectively carried Klebsiella in their gastrointestinal tract.There are no differences between these three groups. 2(25-0%) and 6 (37 5%) of the spondylitic patients with and without gastrointestinal Klebsiella respectively had inflammatory disease of a peripheral joint at the time of study.No patient had active anterior uveitis.Two (25.0%) of the patients with ankylosing spondy- litis and gastrointestinal carriage of Klebsiella had been in hospital within the preceding 7 months.This compares with 1 (6 3%) of patients who did not have gastro- intestinal Klebsiella and with 4 (50 0%) and 8 (44-4%) of the controls with and without gastrointestinal klebsiella respectively.The recent antibiotic usage in patients and controls with and without gastrointestinal Klebsiella was similar.
Ian Ramsay Gray
Authors: Howel Jones
Journal: BMJ (2006)

served in the Royal Army Medical Corps in Normandy, Belgium, and Rhodesia before joining his brother in general practice in Bellshill in industrial Lanarkshire.After retirement in 1978 he did locum work.He was chairman of Lanarkshire Medical Committee for 12 years.In addition to an avid interest in politics, sport, crosswords, and puddings, he supplied family, friends and neighbours with plants annually, and grew show chrysanthemums, winning many prizes locally and nationally.He was chairman of the Scottish Chrysanthemum and Dahlia Society for many years.David survived cancer three times.
Complement-mediated antiserum cytotoxic reactions to human chromosome 7 coded antigen(s): immunoselection of rearranged human chromosome 7 in human-mouse somatic cell hybrids.
Authors: B B Knowles, D Solter, G Trinchieri, K M Maloney, S R Ford, D P Aden
Journal: The Journal of Experimental Medicine (1977)

Immunoselection via complement-dependent lysis of human-mouse somatic cell hybrids containing chromosome 7, with antisera reactive to cell surface antigen(s) coded for by chromosome 7, has resulted in growth of somatic cell hybrids containing rearranged human chromosome 7s. Investigation of these hybrids has localized the gene(s) coding for the relevant cell surface antigen(s) to the short arm of human chromosome 7. The simian virus 40 integration site and the gene coding for human beta-glucuronidase appear to be localized to the long arm of chromosome 7 in this hybrid clone.
A Horseshoe Kidney Detected by Abdominal Scanning with Tc-99m Labeled Red Blood Cells
Authors: SEIICHIRO MORITA, MASATOSHI ISHIBASHI, TOSHIAKI YOSHII, HISASHI OHTAKE
Journal: Clinical Nuclear Medicine (1991)

A horseshoe kidney was diagnosed incidentally while performing an abdominal scan using Tc-99m RBC on a 5-year-old boy with suspected gastrointestinal bleeding. There were repeatedly positive occult blood stool examinations. In the first scintigram, an increase in well-defined activity was found in the right upper abdomen beneath the liver, and was thought to be caused either by bleeding from the gastric antrum or the duodenal bulb. A second abdominal scan with Tc-99m RBC revealed faint radionuclide accumulation in a horseshoe shape with symmetrical, well-defined activity. This activity decreased with time in both images, and, on this basis, a horseshoe kidney was diagnosed.
Comedo naevus of the palm—a sweat duct naevus?
Authors: R.A. MARSDEN, K. FLEMING, R.P.R. DAWBER
Journal: British Journal of Dermatology (1979)

A 9-year-old boy is described with keratotic pits on the left palm, present since birth, which clinically resembled those seen in comedo naevus. Histology and scanning electron microscopy of skin surface replicas showed the lesions to be large, abnormal sweat duets. It is suggested that comedo naevi are not necessarily pilosebaceous in origin and that in our case the term sweat duct naevus may be more appropriate.
Unusual cause of wrist pain in a golfer: Figure 1
Authors: A J McHardy, H P Pollard
Journal: British Journal of Sports Medicine (2004)

Wrist injury is common in golfers and normally occurs at the impact of the club with the ball. The unusual case is reported of a low handicap golfer with wrist pain aggravated by the putting stroke. The condition was resolved with treatment. The likely mechanism for the injury is discussed.
A Mutation in the Human Glucocerebrosidase Gene in Neuronopathic Gaucher's Disease
Authors: Shoji Tsuji, Prabhakara V. Choudary, Brian M. Martin, Barbara K. Stubblefield, June A. Mayor, John A. Barranger, Edward I. Ginns
Journal: New England Journal of Medicine (1987)

To search for a genetic marker for type 2 Gaucher's disease (acute neuronopathic form), we compared the nucleotide sequence of a cloned glucocerebrosidase gene from a patient with Gaucher's disease with a normal gene. We found only a single base substitution (T→C) in exon X. This mutation results in the substitution of proline for leucine in position number 444 and produces a new cleavage site for the NciI restriction endonuclease. We analyzed NciI enzymatic digests of genomic DNA from 20 patients with type 1, 5 with type 2, and 11 with type 3 Gaucher's disease, and 29 normal controls for a restriction-fragment–length polymorphism (RFLP). Four of 5 patients with type 2 disease and all 11 with type 3 disease had at least one allele with the mutation. Two of 5 patients with type 2 disease and 7 of 11 with type 3 were homozygous for this mutation. Only 4 of 20 patients with type 1 Gaucher's disease had the mutant allele and were heterozygous for it. None of the 29 normal controls had the mutant allele. The high frequency of this mutation (444leucine→proline) in patients with neuronopathic Gaucher's disease, detectable by the NciI RFLP, may be of value in the identification of patients who will have the neurologic sequelae of Gaucher's disease. (N Engl J Med 1987; 316:570–5.)
Anti-phospholipid antibodies associated with alcoholic liver disease target oxidized phosphatidylserine on apoptotic cell plasma membranes
Authors: Daria Vay, Cristina Rigamonti, Matteo Vidali, Elisa Mottaran, Elisa Alchera, Giuseppa Occhino, Massimo Sartori, Emanuele Albano
Journal: Journal of Hepatology (2005)
Ascorbic Acid and the Common Cold
Authors: Mason G. Robertson
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Dr. Linus Pauling, Nobel laureate, has adduced impressive arguments to indicate that vitamin C may have an important role, not as yet clearly established, in reducing the incidence of the common cold. Nonetheless, we should not lose sight of the fact that in the 20th century the greatest single contribution to the management of this disorder remains the kleenex.
Factors Associated With the Health Care Utilization of Homeless Persons
Authors: Margot B. Kushel
Journal: JAMA (2001)

numerous barriers to receiving appropriate health care.5][6][7] They are more likely to be admitted to the hospital 8 and to have increased length of hospitalization 9 and may present a substantial burden on the resources of safety-net hospitals and clinics. 10Despite having a higher burden of illness, homeless persons have fewer encounters with ambulatory care than nonhomeless persons. 11For homeless persons, health care competes with more immediate needs, such as obtaining adequate food and shelter. 12However, given the opportunity, homeless persons are willing to obtain health care for chronic conditions if they believe such care to be important. 13hile prior research has described homeless persons' dependence on acute care, such as hospital-based services, 8,14-17 the factors associated with utilization of health care in this population have not been explored from a national perspective.Most research has focused on homeless persons residing in specific cities.Wide variations in characteristics and utilization patterns between different regions make national policy implications difficult to discern from local studies.Homelessness has proven to be a durable problem in diverse regions of the country, creating a large toll of human suffering as well as a complex burden on the safety-net health care system.National policy decisions geared toward decreasing barriers to appropriate health care utilization are needed. METHODSWe performed a secondary data analysis of the factors associated with the use of ambulatory care services, emergency departments, and acute care hospital services and self-perceived barriers to medical care among currently homeless persons included in the National Survey of Homeless Assistance Providers and Cli-ents (NSHAPC). 18The survey, performed in October and November 1996
Cryotherapy in Infants With Retinopathy of Prematurity
Authors: Dale L. Phelps
Journal: JAMA (1989)

Formal decision model analysis for cryotherapy to reduce blindness from retinopathy of prematurity shows that the decision to treat depends substantially on disease severity, the probability of long-term side effects, and correlations of treatment outcomes and side effects for individuals in whom both eyes are treated. The model indicates that both eyes should be treated regardless of disease severity only when the probability of long-term side effects is zero. As risk of long-term side effects increase, treating neither eye or only the worst eye is preferred for an increasingly large spectrum of disease. With high correlations of long-term side effects, treating the worst eye is preferred for moderate levels of disease severity. For high disease severity, treating both eyes is recommended, even when the probability of long-term side effects is high. Better-informed treatment recommendations must await new data to assess risks of long-term side effects and correlations of treatment outcomes and side effects.
Corrigendum to “A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens” [J. Control. Release 161 (2012) 10−17]
Authors: Kazuhiko Matsuo, Yayoi Yokota, You Zhai, Ying-Shu Quan, Fumio Kamiyama, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa
Journal: Journal of Controlled Release (2014)
Sustained benefit of stenting chronic coronary occlusion: long-term clinical follow-up of the Stenting in Chronic Coronary Occlusion (SICCO) study
Authors: Per Anton Sirnes, Svein Golf, Yngvar Myreng, Per Mølstad, Per Albertsson, Arild Mangschau, Knut Endresen, John Kjekshus
Journal: Journal of the American College of Cardiology (1998)
Aspirin shown to reduce risk of pancreatic cancer
Authors: S. Gottlieb
Journal: BMJ (2002)

Aspirin, already known to reduce the risk of colon cancer, may also prevent cancer of the pancreas.

In a seven year study of more than 28000 postmenopausal women aged 55 to 69 who were participants in the Iowa women's health study, the risk of pancreatic cancer was 43% lower in women who took aspirin or products containing aspirin than in women who did not (relative risk 0.57 (95% confidence interval 0.36 to 0.90)). The more often that women took aspirin, the lower their risk of the cancer ( Journal of …
Factors in human endurance.
Authors: R. H. Johnson
Journal: BMJ (1968)

Edward Wilson, one of the greatest Antarctic explorers, was " almost an invalid " when he was chosen as second doctor for the Discovery Expedition in 1901.Only a year before that he was -recovering from tuberculosis at Davos, and yet he was to become Captain Scott's right-hand man.'When Scott, Shackleton, and he went on the sledge journey farthest south on that expedition Shaciketon survived only because of his companions' efforts.In 1910 Wilson went in the Terra Nova on Scott's last attempt on the South Pole itself.On this expedi- tion he took part with Cherry-Garrard and Bowers in "the worst journey in the world.""His last journey was to the Pole itself, and, after both the disappointment of finding Amundsen's Norwegian flag already there and of the tragic deaths of Evans and Captain Oates, Scott, Bowers, and Wilson were caught in a snow blizzard and died of starvation.3It was not a strong physique which made Wilson a great explorer: he stood out because, as Scott said: "He really is the finest character I ever met . . .every quality is so solid and dependable."It was the quality of the man which counted.This was true of Scott himself, as Apsley Cherry-Garrard recalls: " Scott was the strongest combination of a strong man in a strong body that I have ever known.And this because he was so weak!Naturally so peevish, highly strung, irritable, depressed, and moody.Practically such a conquest of himself, such personal and magnetic charm. . . .His triumphs are many-but the Pole was not by any means the greatest of them.Surely the greatest was that he conquered his weaker self and became the strong leader whom we went to follow and came to love."'4" The overriding importance of morale " is stressed also by a recent Working Party on Accident Prevention, though rather more prosaically.5To conclude, however, that survival in difficult conditions depends on courage alone would be a dis- tortion, since there are individual variations in physical capacity and adaptability in different situations.Limiting factors include the individual's physical characteristics, the extent to which the environment imposes difficulties, and the extent to which physiological mechanisms can adapt themselves.I shall con- sider the influence of these factors on performance and also other causes of accidents which may occur in athletic pursuits.
From rags to riches: the atrial fibrillation story
Authors: Tony Delamothe
Journal: BMJ (2012)

Irregularly irregular

Suddenly, irregular heart beat in general and atrial fibrillation in particular is everywhere. The past fortnight alone has seen “heart rhythm week,” organised by the Arrythmia Alliance (patron: Tony Blair), and the National Institute for Health and Clinical Excellence recommend rivaroxaban as stroke prophylaxis for some patients with atrial fibrillation. Although we can’t be sure which cardiac rhythm the footballer Fabrice Muamba collapsed with in March, his “death” and “resurrection” have turned the beatifically smiling footballer into the patron saint of arrhythmias, with his doctors not far behind.

But to return to atrial fibrillation and its humble back story. Not so long ago the main treatment option for the condition was digoxin, one of the active ingredients of a traditional folk remedy for dropsy. Introduced in the 1930s, the drug costs the NHS about £0.04 (€0.05; $0.06) a patient for a daily dose. Costing much the same is warfarin, used to reduce the risk of embolic stroke.

In the past few years, however, new drugs have been crowding in for consideration: dronedarone (for persistent or paroxysmal atrial fibrillation) and angiotensin receptor blockers (for preventing new onset atrial fibrillation). The device industry …
Association of Mouse, Cockroach and Dustmite IgE Levels at Age 2 with Traffic-Related Air Pollution Exposure and Respiratory Symptoms in an Inner City Birth Cohort
Authors: U. Al-alem, C. Lendor, J. Kong, R. Garfinkel, G. Chew, M. Perzanowski, D. Camann, R.M. Whyatt, P.L. Kinney, F. Perera, R.L. Miller
Journal: Journal of Allergy and Clinical Immunology (2006)
Carpal Tunnel Syndrome in Rheumatoid Arthritis. A Prospective Clinical and Electrodiagnostic Study.
Authors: John H. Martin
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Carpal Tunnel Syndrome in Rheumatoid Arthritis. A Prospective Clinical and Electrodiagnostic Study.John H. Martin, M.D., F.A.C.P., Gerald J. Herbison, M.D., William M. Birtwell, M.D., (Associate), Chao Son Teng, M.D., Charles D. Tourtellotte, M.D., F.A.C.P.John H. Martin, M.D., F.A.C.P.Search for more papers by this author, Gerald J. Herbison, M.D.Search for more papers by this author, William M. Birtwell, M.D., (Associate)Search for more papers by this author, Chao Son Teng, M.D.Search for more papers by this author, Charles D. Tourtellotte, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-811_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of carpal tunnel syndrome with rheumatoid arthritis has been the subject of conflicting reports. The following investigation was undertaken in an attempt to clarify the interrelationships of symptoms, signs, and electrodiagnostic tests of carpal tunnel syndrome to rheumatoid arthritis.Thirty-three patients with definite or classical rheumatoid arthritis were selected at random. The anatomical stage, functional classification, Lansbury index, and dolorimeter score of wrists were determined. Two-point discrimination and touch were documented. The patients were questioned regarding symptoms of dysesthesias. Tinel's and Phalen's tests were performed. Motor and sensory nerve conduction velocity of the median and ulnar nerves was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 811-811KeywordsNervesRheumatoid arthritisSigns and symptomsTouch Issue Published: 1 May 1970 PDF DownloadLoading ...
122 Hematopoietic stem cell mobilization in patients undergoing liver transplant or liver resection
Authors: E. Loggi, A. Gramenzi, S. Talarico, L. Catani, G.L. Grazi, U. Baccarani, M. Fogli, G. Vetrone, M. Aluigi, G. Marzocchi, S. Lorenzini, M. Bernardi, A.D. Pinna, F. Bresadola, M. Baccarani, R.M. Lemoli, P. Andreone
Journal: Journal of Hepatology (2006)
What is the most effective management of neurogenic bladder dysfunction?
Authors: B. Buckley, A. M Grant
Journal: BMJ (2009)

<h3>Abstract</h3> <b>Objective:</b> To assess the prevalence of human T cell leukaemia/lymphoma virus (HTLV) infection in pregnant women in the United Kingdom. <b>Design:</b> Population study. <b>Subjects:</b> Guthrie card samples from babies born in 1997-8.Samples were linked to data on mother9s age and ethnic status and parents9 country of birth and then anonymised. <b>Setting:</b> North Thames Regional Health Authority. <b>Main outcome measures:</b> Presence of antibodies against HTLV in eluates tested by gelatin particle agglutination assay and results confirmed by immunoblot. <b>Results:</b> Of 126 010 samples tested, 67 had confirmed antibodies to HTLV (59 HTLV-I, 2 HTLV-II, 6 untyped) and six had indeterminate results. Seroprevalence was 17.0 per 1000 (95% confidence interval 9.2 to 28.3) in infants whose mothers were born in the Caribbean, 3.2/1000 (1.5 to 5.9) with mothers born in west and central Africa, and 6.8/1000 (3.1 to 12.9) in infants of black Caribbean mothers born in non-endemic regions. In infants with no known risk (both parents born in non-endemic regions and mother not black Caribbean) seroprevalence was 0.06-0.12 per 1000. Mother9s country of birth, father9s country of birth, and mother9s ethnic status were all independently associated with neonatal seroprevalence. An estimated 223 (95% confidence interval 110 to 350) of the 720 000 pregnant women each year in the United Kingdom are infected with HTLV. <b>Conclusions:</b> The prevalence of HTLV and HIV infections in pregnant women in the United Kingdom are comparable. The cost effectiveness of antenatal HTLV screening should be evaluated, and screening of blood donations should be considered.