Streptokinase Therapy for Thromboembolic Occlusive Vascular Disease
Authors: SOL SHERRY
Journal: Annals of Internal Medicine (1971)

Editorials1 March 1971Streptokinase Therapy for Thromboembolic Occlusive Vascular DiseaseSOL SHERRY, M.D.SOL SHERRY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-3-437 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present decade will probably show the extent to which thrombolytic therapy can be applied for benefit in the management of thromboembolic occlusive vascular disease. Two agents, streptokinase and urokinase, when used in appropriate dosage, have been shown to produce in vivo an active thrombolytic state. Although the experience with each differs markedly (a hundredfold greater with streptokinase), both agents are being evaluated under practical clinical circumstances that should define their usefulness as well as their indications, contraindications, and hazards.The recent publication of several symposia on thrombolytic therapy with streptokinase (1, 2)...References1. Symposium on thrombolytic therapy with streptokinase. Aust Ann Med 19 (suppl l):1-77, 1970 MedlineGoogle Scholar2. HIEMEYER V (ed.): Internationales Symposion. Therapeutische und Experimentelle Fibrinolyse. Stuttgart, F.K. Schattauer Verlag, 1969 Google Scholar3. VERSTRAETEVERMYLENDONATI MJM: The effect of streptokinase infusion on chronic arterial occlusions and stenoses. Ann Intern Med 74:377-382, 1971 LinkGoogle Scholar4. JOHNSONMCCARTY AW: Lysis of artificially induced intravascular clots in man by intravascular infusion of streptokinase. J Clin Invest 38:1627-1643, 1959 CrossrefMedlineGoogle Scholar5. FLETCHERALKJAERSIGSHERRY ANS: The maintenance of a sustained thrombolytic state in man. I. Induction and effects. Ibid., p. 1096-1110 Google Scholar6. SHERRYFLETCHERALKJAERSIG SAN: Fibrinolysis and fibrinolytic activity in man. Physiol Rev 39:343-382, 1959 CrossrefMedlineGoogle Scholar7. POLIWODAALEXANDERBUHL HKV: Treatment of chronic arterial occlusions with streptokinase. New Eng J Med 280:689-692, 1969 CrossrefMedlineGoogle Scholar8. : The urokinase-pulmonary embolism trial. Phase I results. JAMA 214:2163-2172, 1970 CrossrefMedlineGoogle Scholar9. SCHMUTZLERHECKNERKORTGE RFP: Thrombolytic therapy of recent myocardial infarction. I. Introduction, plan of trial, general clinical results. German Med Monthly 11: 308-314, 1966 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Temple University School of Medicine Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical uses of microorganisms and their productsImmobilization of the plasminogen activator streptokinase and its fibrinolytic effects vivoTheoretical and Practical Aspects of Thrombolytic TherapyAnticoagulantsComplication of snakebite successfully treated with streptokinasePrimary and Chronic Thromboembolic Pulmonary HypertensionChapter 8. Antithrombotic AgentsManagement of ThrombosisDigitalis IntoxicationARTERIAL THROMBOLYSISRESECTION OF THE OESOPHAGUS 1 March 1971Volume 74, Issue 3Page: 437-440KeywordsVascular diseases Issue Published: 1 March 1971 PDF downloadLoading ...