tbuckley/cabot-search huggingface dataset:
Accurate Grading of 3 Synchronous Liposarcomas Assessed by PET-CT in a Single Patient
Authors: Madhusudhan P. Reddy, Guillermo P. Sangster, Amol M. Takalkar, Maureen Heldmann, Ruo-dan Zhang, David L. Lilien
Journal: Clinical Nuclear Medicine (2007)

Positron emission tomography (PET) with 2-fluoro-deoxyglucose (FDG) has become an established imaging modality that can accurately and noninvasively differentiate malignant neoplasms from benign masses. It is increasingly being used to grade malignant neoplasms as well and has almost replaced other studies like gallium 67-citrate scans for metabolic imaging. We describe an interesting case of 3 synchronous liposarcomas with different radio-opacifications on computed tomography (CT). The more aggressive lesion with more opacity on CT showed intense FDG activity and was found to be a high-grade liposarcoma on pathology. The well-differentiated lesion with more fat content appearing less radio-opaque on CT showed almost no FDG activity and an intermediate grade lesion with intermediate radio-opacity on CT showed mildly increased FDG activity. Dual modality imaging with integrated PET/CT systems have strengthened the confidence of classifying these lesions even before knowing the pathology as depicted in this case.
Theca-Lutein Cysts of the Ovaries
Authors: Paul Rabinowitz
Journal: JAMA (1961)

ERYTHROBLASTOSIS hydrops fetalis may be associated with bilateral theca-lutein cysts of the ovaries.<sup>1</sup>The patient presented here had not only these unusual findings, but also toxemia of pregnancy, and abruptio placentae with acute renal failure. <h3>Report of a Case</h3> A 25-year-old woman was found to have an Rh incompatibility during her initial pregnancy, 5 years prior to her present illness. Her first 2 pregnancies had been uneventful, although her second child had a meningocele which was readily repaired. Her third pregnancy terminated in spontaneous abortion, and her fourth pregnancy resulted in a 15-lb. hydropic fetus which was delivered by cesarian section. During the following year, when the patient again became pregnant, she developed proteinuria, peripheral edema, and borderline hypertension. In the 28th week of pregnancy, she had an attack of severe abdominal pain with vomiting and vaginal bleeding. The uterus was found to be rigid and tender. A diagnosis
Montelukast, a leukotriene receptor antagonist, reduces the concentration of leukotrienes in the respiratory tract of children with persistent asthma☆☆☆★
Authors: Benjamin Volovitz, Elvan Tabachnik, Moshe Nussinovitch, Biana Shtaif, Hanna Blau, Irit Gil-Ad, Abraham Weizman, Itzhak Varsano
Journal: Journal of Allergy and Clinical Immunology (1999)
Defective natural killer–cell cytotoxic activity in NFKB2-mutated CVID-like disease
Authors: Vassilios Lougaris, Giovanna Tabellini, Massimiliano Vitali, Manuela Baronio, Ornella Patrizi, Giacomo Tampella, Augusto Biasini, Daniele Moratto, Silvia Parolini, Alessandro Plebani
Journal: Journal of Allergy and Clinical Immunology (2015)
THE RELATIONSHIP OF SERUM ERYTHROPOIETIN LEVEL WITH CORONARY COLLATERAL DEVELOPMENT
Authors: Asife Sahinarslan, Ridvan Yalcin, Sinan Kocaman, Salih Topal, Ugur Ercin, Ali C. Tanalp, Neslihan Bukan, Bulent Boyaci, Atiye Cengel
Journal: Journal of the American College of Cardiology (2010)
Community-Academic Health Care Partnership-Reply
Authors: David M. Levine
Journal: JAMA (1995)

In Reply.  —Dr Smith appropriately has raised the concern that costs of medical care are greater in academic health centers than in community-based practice. We are not proposing that additional grants be made directly to academic centers to provide medical care on site. Our recommendation is to provide financial incentives to academic health centers, dependent on their being involved in a true partnership with their communities, using complements to traditional medical care located in neighborhoods to address health care needs in a more timely, effective, and less costly manner. To enhance the economic well-being as well as the health status of community populations, our approach places the emphasis on community development and leadership and on community-based health promotion and disease prevention programs operated by neighborhood-based, culturally sensitive personnel. Such an approach thus would provide less costly community-based programs that are designed to decrease the need for more expensive hospital-based care
Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic purpura
Authors: Marie Moatti-Cohen, Céline Garrec, Martine Wolf, Pierre Boisseau, Lionel Galicier, Elie Azoulay, Alain Stepanian, Yahsou Delmas, Eric Rondeau, Stéphane Bezieau, Paul Coppo, Agnès Veyradier
Journal: Blood (2012)
Standards for Monitoring During Anesthesia at Harvard
Authors: Arthur W. Peterson
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The article entitled "Standards for Patient Monitoring During Anesthesia at Harvard Medical School"<sup>1</sup>does a disservice to the practicing anesthesiologist and a service to the legal profession. For example, the article states that "monitoring end-tidal carbon dioxide is an emerging standard and is strongly preferred." In almost 30 years of anesthesia practice, I have yet to encounter a case in which the outcome could have been changed by the presence of such a monitor. Does this mean that every anesthesia department in the country will have to use hard-to-come-by dollars to buy such monitors? And how eager will malpractice lawyers be to confront the anesthesiologist—when a fatal outcome can possibly be traced to anesthesia—with the statement that the anesthesiologist was at fault for not using a carbon dioxide monitor? This article has given the legal profession an easy checklist to use when encountering any malpractice case
Western Humanism, Modern Liberal Politics, and Psychiatric Training: Friends or Foes?
Authors: ARNOLD J. MANDELL
Journal: American Journal of Psychiatry (1973)

Liberalism once nourished the growth of an enlightened humanism upon the rigid constructs of analytic psychiatry. The New Left promulgates definitions of psychiatrists that are inimical to the basic postulates of psychiatry. They involve the nature of mental illness. individual responsibility for it, and the role of the professional in relation to it. American psychiatric education is challenged to train people who can cure the ills of society, but would be denied by the New Left the very tools with which we have learned to heal.
Clinical Application of Argon Plasma Coagulation in Gastrointestinal Endoscopy: Has the Time Come to Replace the Laser?
Authors: J. Canard, B. Védrenne
Journal: Endoscopy (2001)

Argon plasma coagulation (APC) is a recently introduced treatment in digestive endoscopy. Since the first description of this technique [1], and of early endoscopic experience with it [2], it has become more and more widely used, so that the question arises of whether it should replace the laser in some of its indications, or in most of them, or even in all of them. In fact, its expected advantages are numerous and have been recently reiterated [3] [4] . The main ones are the following: effective and safe coagulation; noncontact mode (2 - 10 mm); axial, radial, and retrograde application; controllable depth of coagulation (0.5 - 3 mm); marked desiccation; no destruction of metal stents; little smoke or vapor; mobile handy apparatus; steerable, robust, and cheap applicators; low cost in purchase, use, and maintenance and no extended safety precautions. In this review we sum up the situation regarding the published data on the main indications of APC in gastrointestinal diseases, and to compare the results in medical literature with our own experience in, up to now, more than 300 patients.
Warning Against Fraudulent Insurance Agent.
Authors: A. H. Hayden
Journal: JAMA (1906)

Summerville, S. C., April 27, 1906. <h3>To the Editor:</h3> —If you will give publicity to the following you will do our profession a great service and aid in placing in the penitentiary one of the nerviest thieves in America. A man, six feet in height, with stubby, iron-gray moustache, large gray eyes with a decided outward and downward slant, rather prominent eyeballs, hair slightly curly, iron gray and rather thin over the forehead and on top of the head, weighing 260 pounds and about 60 years of age is traveling the country over, purporting to be an agent of the Columbian National Life Insurance Company. He has swindled a number of physicians in Charleston by the following scheme: He shows credentials as agent of the company and offers to appoint his intended victim a medical examiner and sell him stock of the company at a reduced price, representing that the
ImmunTraCkeR® as a reliable TCR repertoire profiling tool to understand immune response and to explore immunotherapy biomarkers
Authors: Isabelle Tanneau, Audrey Nondé, Anaïs Courtier, Gilles Parmentier, Marlène Noël, Audrey Grivès, Solène Perez, Nadia Plantier, Jean-François Mouret, Orchidée Filipe-Santos, Manuarii Manuel
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Over the last decade, the host immunity has emerged as a critical determinant of cancer development and of response to therapy. Great progress has been made in the development of immunotherapies, which leverage the patient’s immune system to reach better clinical outcomes.
Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings.
Authors: A Maes, W Flameng, J Nuyts, M Borgers, B Shivalkar, J Ausma, G Bormans, C Schiepers, M De Roo, L Mortelmans
Journal: Circulation (1994)

In patients with chronic coronary artery disease (CAD) and left ventricular dysfunction, flow/metabolic studies of the myocardium with positron emission tomography (PET) are able to distinguish viable but dysfunctional myocardium from irreversible ischemic injury and scar tissue. In this study, PET findings of blood flow and metabolism in chronically hypoperfused myocardium were correlated with histology.We studied 33 patients suffering from CAD. In each patient, myocardial blood flow and metabolism were measured with PET 1 or 2 days before revascularization. During surgery, transmural biopsies were taken from the left ventricular anterior wall and planimetrically scored for the degree of myolysis (sarcomere loss). The amount of connective tissue was calculated using morphometric techniques. Contrast ventriculography demonstrated abnormal wall motion in 23 patients. Fourteen patients with a mismatch pattern (decreased flow with preserved metabolism) in the biopsy region after quantitative analysis of the PET data showed 11 +/- 6 vol% fibrosis and 25 +/- 13% cells with sarcomere loss. The space formerly occupied by sarcomeres was mainly replaced by glycogen and mitochondria. A significant wall motion improvement was noted 3 months after surgery. Nine patients showed a match pattern (concordant flow/metabolism defects). The biopsies revealed 35 +/- 25% fibrosis and 24 +/- 15% glycogen-storing cells. The biopsies of the 10 patients with normal anterior wall motion showed 8 +/- 4% fibrosis and 12 +/- 8% glycogen-accumulating cells.It can be concluded that areas with impaired wall motion and a PET match pattern show extensive fibrosis. Regions with reduced flow and preserved FDG metabolism, however, contain predominantly viable cells. In these regions, significant recovery of wall motion is found after revascularization. Regions with normal wall motion contain predominantly viable cells. Cells with reduced contractile material and increased glycogen content are mainly found in areas with wall motion impairment but are also present in areas with normal wall motion and a severe stenosis of the coronary vessel.
Genesis of Hepatitis
Authors: Frederik B. Bang
Journal: New England Journal of Medicine (1969)

J. B. S. Haldane is credited with first clearly pointing out that disease is one of the major selective forces in evolution, and that genetic resistance to disease in nature is therefore to be expected.1 Subsequent research in the area has followed two general directions. Sabin's pioneering study of experimental viral encephalitis in mice2 demonstrated that individual genes, inherited as simple mendelian units, may be responsible for resistance and susceptibility to certain experimental virus diseases, but that genetic resistance to one virus infection did not necessarily confer resistance to other viruses, as he showed with poliomyelitis and rabies. Subsequently, it . . .
A community study of snoring and sleep-disordered breathing. Prevalence.
Authors: L G Olson, M T King, M J Hensley, N A Saunders
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We conducted a study of the prevalence of sleep-disordered breathing in subjects derived from a random sample of the population. A total of 2,202 subjects 35 to 69 yr of age were approached. Four hundred forty-one answered a questionnaire concerning their sleep symptoms, general health, and habits such as alcohol consumption, and they were monitored for sleep-disordered breathing (SDB). The sample was biased in favor of snorers and those with other subjective sleep complaints. Fifty-six percent of the subjects were men. Of the 441 subjects 79 (17.9%) had SDB (more than 15 episodes of apnea or hypopnea per hour: respiratory distress index [RDI] > or = 15), 289 were snorers but had RDI < 15, and 73 were nonsnorers. The prevalence of SDB in this sample was therefore at least 3.6% (79 of 2,204). The minimum prevalence in men was 5.7%, and in women it was 1.2%. Logistic regression identified only male sex as an independent predictor of snoring without SDB (adjusted odds ratio [OR], 3.24; 95% CI, 1.33 to 7.82), body mass index (adjusted OR for an increase of 5 kg/m2, 0.95; 95% CI, 0.85 to 1.05), and alcohol consumption (adjusted OR for an increase of 10 g/day, 1.05; 95% CI, 0.84 to 1.37) were not significant predictors of snoring. The independent predictors of SDB among snorers were age (adjusted OR for an increase of 5 yr, 1.26; 95% CI, 1.08 to 1.47) and neck circumference (adjusted OR for an increase of 2 cm, 1.53; 95% CI, 1.16 to 2.00).(ABSTRACT TRUNCATED AT 250 WORDS)
An audit of the impact of a consultation with a paediatric dermatology team on quality of life in infants with atopic eczema and their families: further validation of the Infants’ Dermatitis Quality of Life Index and Dermatitis Family Impact score
Authors: P.E. Beattie, M.S. Lewis-Jones
Journal: British Journal of Dermatology (2006)

Journal Article An audit of the impact of a consultation with a paediatric dermatology team on quality of life in infants with atopic eczema and their families: further validation of the Infants' Dermatitis Quality of Life Index and Dermatitis Family Impact score Get access P.E. Beattie, P.E. Beattie Department of Dermatology, Ninewells Hospital, Dundee DD1 9SY, U.K Paula E. Beattie, Department of Dermatology, Royal Hospital for Sick children, Yorkhill, Glasgow G3 8SJ, U.K. E‐mail: paula.beattie@northglasgow.scot.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar M.S. Lewis‐Jones M.S. Lewis‐Jones Department of Dermatology, Ninewells Hospital, Dundee DD1 9SY, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 6, 1 December 2006, Pages 1249–1255, https://doi.org/10.1111/j.1365-2133.2006.07525.x Published: 01 December 2006 Article history Accepted: 14 June 2006 Published: 01 December 2006
New Viral Diseases
Authors: Edwin D. Kilbourne
Journal: JAMA (1990)

Viruses are the most mutable and rapidly evolving human parasites. Therefore, it is not surprising that new virus diseases, such as the acquired immunodeficiency syndrome, are emerging. However, these new viruses are relatively few in number, which reflects the constraints placed on viral evolution by the requirement for maintenance of virus structure and function and virus adaptation to restricted ecologic sites. Most "new" viral diseases, such as the hemorrhagic fevers, result from environmental disruptions that increase human contact with animals or insect vectors of old viruses. However, truly novel viruses with lethal potential or capacity for global spread have emerged in animals as a consequence of single-point mutations or genetic recombination between viruses. Given the mutability of viruses and the inevitability of environmental change, we must be prepared for the evolution of new virus diseases. (<i>JAMA</i>. 1990;264:68-70)
Pathogenesis of Campylobacter fetus infections. Role of surface array proteins in virulence in a mouse model.
Authors: Z Pei, M J Blaser
Journal: Journal of Clinical Investigation (1990)

We developed a mouse model to compare the virulence of Campylobacter fetus strains with (S-plus) and without (S-minus) surface array protein (S-protein) capsules. In adult HA/ICR mice pretreated with ferric chloride, the LD50 for S-plus strain 84-32 was 43.3 times lower than its spontaneous S-minus mutant 84-54. Seven strains of inbred mice were no more susceptible than the outbred strain. In contrast to the findings with Salmonella typhimurium by others, 3 X 10(7) CFU of strain 84-32 caused 90% mortality in C3H/HeN (LPSn) mice and 40% mortality in C3H/HeJ (LPSd) mice. High-grade bacteremia in HA/ICR mice occurred after oral challenge with S-plus C. fetus strains and continued for at least 2 d, but was not present in any mice challenged with S-minus strains. Bacteremia at 30 min after challenge was 51.6-fold lower in mice pretreated with 10 microliters of rabbit antiserum to purified S-protein than after pretreatment with normal rabbit serum. Challenge of mice with a mixture of S-minus strain 84-54 and free S-proteins at a concentration 31.1-fold higher than found in wild-type strain 84-32 caused 30% mortality, compared with 0% with strain 84-54 or S-protein alone. These findings in a mouse model point toward the central role of the S-protein in the pathogenesis of C. fetus infection. The S-protein is not toxic per se, but enhances virulence when present on the bacterial cell surface as a capsule.
RHEUMATOID ARTHRITIS, WITH REPORT OF TWO CASES.
Authors: DAVID RIESMAN
Journal: JAMA (1897)

Despite the increasing literature on the subject of rheumatoid arthritis, the ultimate nature of the disease is far from clearly established, and even at this date we do not positively know just what affections of the joints should be grouped under the name. Nothing so clarifies the nosographic atmosphere as the discovery of causes—only through causal knowledge are we able to separate diseases that are similar and to assign to them a definite place in our systems. How easy it has become for us to define typhoid fever, diphtheria, and malaria, since their etiology has been determined. As we are still unable to point out the true cause of rheumatoid arthritis, it would, I believe, be better, following the example of Virchow, Garrod, and others, to use the phrase<i>arthritis deformans</i>, as that expresses the most prominent symptom and is non-committal on the score of pathogenesis. <h3>Morbid anatomy.</h3> —The lesions
Reliability and Validity of the Niddk–Qa Instrument in the Assessment of Quality of Life in Ambulatory Patients With Cholestatic Liver Disease
Authors: Ray W. Kim, Keith D. Lindor, Michael Malinchoc, Jan L. Petz, Roberta Jorgensen, Rolland E. Dickson
Journal: Hepatology (2000)

The NIDDK–QA instrument, developed and widely used in liver transplant recipients, assesses quality of life (QOL) in four domains, including liver disease symptoms, physical function, health satisfaction, and overall well–being. We investigated whether the instrument may be used as a disease–specific instrument in ambulatory patients with cholestatic liver disease. The NIDDK–QA instrument was administered in 96 patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) seen at the Mayo Clinic. The SF–36, a well–established generic instrument, was also administered. Standard measures for test–retest reliability, internal consistency, and discriminant and concurrent validity were examined. All patients were ambulatory with mostly normal levels of serum bilirubin and albumin concentrations. The reliability of the NIDDK–QA, as measured by test–retest correlation (Pearson coefficients: 0.82–0.99, P &lt; .01) and by internal consistency (Cronbach's alpha: 0.87–0.94) exceeded conventional acceptability criteria. The correlation between domain scores of the NIDDK–QA and SF–36 was clear and logical in that the physical function domain of NIDDK–QA strongly correlated with the physical component summary score of SF–36 ( r = 0.86, P &lt; .01). The overall well–being domain of the NIDDK–QA was closely associated with the mental summary score of SF–36 ( r = 0.69, P &lt; .01). Among PBC patients, there was a modest yet significant correlation between the Mayo risk score and overall well–being ( r = -0.26, P = .03). In the assessment of QOL in patients with cholestatic liver disease, NIDDK–QA is found reliable and valid. These data, combined with our previous study, demonstrate its applicability in a wide spectrum of disease severity, ranging from early, ambulatory–phase disease to decompensated cirrhosis necessitating liver transplantation.
Improvement targets for <i>C difficile</i> must be valid
Authors: M A Cooper, P M Hawkey
Journal: BMJ (2007)

We have identified a potentially distorting factor in the delivery of reductions in Clostridium difficile rates.1 A letter sent to chief executives of trusts, primary care trusts, and strategic health authorities in England in December 2006 stated that the forthcoming NHS operating framework for 2007-8 and the NHS contract require primary care trusts to agree a local target with their acute hospital providers for a significant reduction in C difficile infections.2 The target …
Additive effects of angiotensin converting enzyme inhibitor combined with statin on inflammation and fibrinolysis in hypercholesterolemic patients with coronary artery disease
Authors: Kwang K. Koh, Ji W. Son, Jeong Y. Ahn, Mi-Seung Shin, In S. Choi, Eak K. Shin
Journal: Journal of the American College of Cardiology (2003)
Molecular Evolution of Recombination Hotspots and Highly Recombining Pseudoautosomal Regions in Hominoids
Authors: Soojin Yi, Wen-Hsiung Li
Journal: Molecular Biology and Evolution (2005)

We examined the effects of recombination on the molecular evolution of noncoding regions in pseudoautosomal regions (PARs) and recombination hotspots in hominoids. The PAR-linked regions analyzed had on average longer branch lengths than those of the recombination hotspots. Moreover, contrary to previous observations, we found no correlation between recombination rate and silent site divergence in our data set and little change in the GC content during recent hominoid evolution. This suggests that the current rate of recombination is not a good indicator of the past rates of recombination for these highly recombining regions. Furthermore, human recombination hotspots show increased AT to GC substitutions in the human lineage, while no such pattern is detected for PAR-linked regions. Together, these observations suggest that recombination hotspots in hominoids are transient in the evolutionary time-scale. Interestingly, the 16p13.3 recombination hotspot locus violates a local molecular clock, though the locus appears to be noncoding and should evolve neutrally. We hypothesize that sudden changes in recombination rate have caused the changes in substitution rate at this locus.