tbuckley/cabot-search huggingface dataset:
Polychlorinated biphenyls alter extraneuronal but not tissue dopamine concentrations in adult rat striatum: an in vivo microdialysis study.
Authors: Richard F Seegal, Richard J Okoniewski, Karl O Brosch, Jeffrey C Bemis
Journal: Environmental Health Perspectives (2002)

Polychlorinated biphenyls (PCBs) reduce tissue dopamine (DA) concentrations and increase media DA concentrations in both in vitro preparations of bovine adrenal chromaffin cells and adult rat striatal tissue. To determine whether these changes also occur in the intact animal, we used in vivo microdialysis to determine changes in concentrations of DA in striatal dialysates from freely moving adult male rats after exposure to 25 mg/kg/day Aroclor 1254 for varying periods of time. We also determined DA concentrations in striatal tissue obtained postmortem from similarly treated animals. The effects of PCBs on dialysate DA concentrations depended on the length of exposure; DA concentrations were significantly elevated after 3 days of exposure and were significantly reduced after exposure for periods of 1 week or longer. On the other hand, striatal tissue concentrations of DA, determined postmortem in rats exposed to PCBs for the same periods of time, were not significantly altered. We suggest that these time-dependent alterations in dialysate DA concentrations a) reflect PCB-induced alterations of both plasma membrane and vesicular DA transporter function; b) provide a more sensitive index of altered central DA function after exposure to PCBs than does measurement of postmortem tissue DA concentrations; and c) play an important role in mediating some PCB-mediated changes in behavior.
Distal Chr 4 Harbors a Genetic Locus (<i>Gct1</i>) Fundamental for Spontaneous Ovarian Granulosa Cell Tumorigenesis in a Mouse Model
Authors: Ann M. Dorward, Kathryn L. Shultz, Lindsay G. Horton, Renhua Li, Gary A. Churchill, Wesley G. Beamer
Journal: Cancer Research (2005)

Abstract The spontaneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls. To expedite gene discovery in this mouse model of childhood cancer, we did a gene mapping study with the SWXJ-9 recombinant inbred strain and the evolutionarily divergent Mus musculus castaneus (CAST/Ei) strain as a mapping partner. Our mapping strategy focused on autosomal determinants of susceptibility with a backcross scheme that exploited a paternal, parent-of-origin effect for a X-linked gene (Gct4) that strongly supports granulosa cell tumor development. Of 1,968 backcross females examined, we detected 81 granulosa cell tumor-bearing animals and compared their allelic inheritance patterns to non-tumor-bearing siblings in a case-control analysis. The results of our study have confirmed an important locus on mouse chromosome (Chr) 4 (Gct1) and have revealed new loci for granulosa cell tumor susceptibility (Gct7-Gct9) on Chrs 1, 2, and 13 with susceptibility alleles contributed by the SWXJ-9 progenitor. Two novel gene-gene interactions supportive for granulosa cell tumor development were also observed between loci on Chrs 17 and 18 and loci on Chrs 2 and 10. Our data substantiate the evidence that Gct1 on Chr 4 is a fundamental oncogene for granulosa cell tumorigenesis in mice and has identified additional interacting autosomal loci that support tumor development.
A SIMPLE MECHANICAL DEVICE TO PREVENT THE MISCOUNT OF SPONGES.
Authors: Zell Converse
Journal: JAMA (1901)

The unfortunate accident in a Columbus hospital a few years ago, and the universal expression of trained nurses as to the responsibility assumed by them in accounting for the sponges used, impresses upon the mind of the writer not only the convenience and value, but the almost absolute necessity of some arrangement which would render a miscount impossible. The following described simple device then came to mind, and was suggested to one of our leading surgeons, who has since used it both in hospital and private practice; in a published report he speaks of it as devoid of complications and in every way eminently satisfactory. Any ordinary table may be used, but one at least 36 inches in length and a little wider than is necessary to hold two sponge basins, will be found most convenient. To this is attached at the back of the top an upwardly inclined surface
574 INTERIM 48 WEEK RESULTS OF A RANDOMIZED TRIAL OF EMTRICITABINE/TENOFOVIR DF PLUS/MINUS HBIG WITHDRAWAL IN POST-ORTHOTOPIC LIVER TRANSPLANT RECIPIENTS FOR CHRONIC HEPATITIS B
Authors: L. Teperman, J. Spivey, F. Poordad, T. Schiano, N. Bzowej, P. Martin, D. Coombs, K.R. Hirsch, J. Anderson
Journal: Journal of Hepatology (2011)
Opposite responses of nuclear spermidineN8-acetyltransferase and histone acetyltransferase activities to regenerative stimuli in rat liver
Authors: Maria Alfonsina Desiderio
Journal: Hepatology (1992)

ABSTRPlCT Experiments performed in different models of hepatic regeneration at the time of maximal DNA synthesis, determined by thymidine kinase activity assay, demonstrated that spermidine N 8 –acetyltransferase activity increased 48 hr after CCl 4 administration (2–fold), 72 hr after CCl 4 plus phenobarbital (3–fold) and 24 hr after partial hepatectomy (4.5–fold). On the contrary, at these times histone acetyltransferase activity diminished (approximately twofold) and was unchanged compared with control values in the liver of hepatotoxin–treated and hepatectomized rats, respectively. Histone acetylation was, however, enhanced 1.5–fold before the onset of DNA replication (14 hr), and 3.4–fold after the peak of DNA synthesis (32 hr) in the liver of hepatectomized rats. α–Difluoromethylornithine, a specific and irreversible inhibitor of ornithine decarboxylase that was administered to hepatectomized rats, blocked polyamine synthesis, thymidine kinase activity and consequently liver regeneration 24 hr after the surgery. In those conditions, spermidine N 8 –acetyltransferase activity was decreased approximately twofold, whereas histone acetyltransferase activity was elevated approximately twofold. All these effects were reversed by putrescine coadministration. Altogether, these findings showed that nuclear spermidine N 8 –acetyltransferase and histone acetyltransferase activities were regulated in opposite ways during the processes associated with liver regeneration. Moreover, they suggested that the polyamines themselves might have a direct or indirect role in this regulation. (Hepatology 1992;15:928-933).
Diet and the diabetic.
Authors: H Dorchy, H Loeb, C Ernould
Journal: BMJ (1976)

Diet and the diabetic SIR,-We wish to comment on your leading article on this subject (2 October, p 781) and to report briefly the opinion of most paediatric diabetologists.We are often in disagreement with the dietetic management recommended by diabetologists concerned with diabetic adults.As we are not permitted free expression within the International Diabetes Federation, we formed, in 1972, the International Study Group of Diabetes in Children and Adolescents.Although we have representatives of 13 countries, unfortunately Great Britain is not yet included.We therefore take this opportunity to invite our British colleagues to join us so that we may work together in this study group.It is evident that both paediatricians and internists concerned with diabetes in childhood are trying to establish the best possible degree of metabolic control'-that is, minimum glycosuria, normal blood lipids, avoidance of hypo-and hyper-glycaemia (which is a factor in the development of angiopachy), and normal growth.2We have shown by angiofluorography that in children there exists a correlation between diabetic retinopathy and degree of
Group-wise construction of reduced models for understanding and characterization of pulmonary blood flows from medical images
Authors: Romain Guibert, Kristin McLeod, Alfonso Caiazzo, Tommaso Mansi, Miguel A. Fernández, Maxime Sermesant, Xavier Pennec, Irene E. Vignon-Clementel, Younes Boudjemline, Jean-Frédéric Gerbeau
Journal: Medical Image Analysis (2013)
Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis
Authors: Rajat Deo, Amit Khera, Darren K. McGuire, Sabina A. Murphy, Januario de P. Meo Neto, David A. Morrow, James A. de Lemos
Journal: Journal of the American College of Cardiology (2004)
Screening Blood Donors by Computer Interview-Reply
Authors: Steven E. Locke
Journal: JAMA (1993)

<h3>In Reply.</h3> —We thank Mr Wright and Dr Silberstein for their comments on the benefits of computer-based interviewing, although we do not agree that its validation is in an embryonic stage. Indeed, computer-based interviewing was described as early as 1966,<sup>1</sup>and studies of its utility have yielded positive findings, particularly with regard to the issue of patients' willingness to disclose information of a private and personal nature.<sup>2</sup> Wright and Silberstein have called attention to the sensitivity and specificity of computer-based interviews in detecting HIV-related risk factors among prospective blood donors. We developed the computer-based interview because of the need to identify potential donors who have recently become infected with HIV but have not yet developed anti-HIV antibodies. These donors pose the greatest threat to the recipients of blood products because there is no blood test sensitive enough to guarantee their identification. (More than 99.98% of all HIV-infected donors
Where have all the nurses gone?
Authors: J W Paulley
Journal: BMJ (1980)

<b>PURPOSE</b> We investigated the 10-year mortality rates in a trial that tested a case-based intervention in primary care aimed at reducing the gap between evidence-based goals and clinical practice in patients with coronary heart disease (CHD). <b>METHODS</b> A prospective randomized controlled pragmatic trial was undertaken in a primary care setting. New evidence-based guidelines, with intensified lipid-lowering recommendations in CHD, were mailed to all general practitioners in the region and presented at a lecture in 1995. General practitioners (n = 54) and patients with CHD (n = 88) were assigned according to their primary health care center to 2 balanced groups and randomly allocated to usual care as a control or to an active intervention. General practitioners in the intervention group participated in repeated case-based training during a 2-year period. Patients whose CHD was treated by specialists (n = 167) served as an internal specialist comparison group. Altogether, 255 consecutive patients were included. Cox regression analysis was used to detect any survival benefit of the intervention. <b>RESULTS</b> At 10 years, 22% of the patients in the intervention group had died as compared with 44% in the control group (<i>P</i> = .02), with a hazard ratio of 0.45 (95% confidence interval, 0.20–0.95). This difference was mainly due to reduced cardiovascular mortality in the intervention group (<i>P</i> = .01). In addition, the mortality rate of 22% in the intervention group was comparable to the rate of 23% seen in patients treated by a specialist. <b>CONCLUSIONS</b> Use of case-based training to implement evidence-based practice in primary care was associated with decreased mortality at 10 years in patients with CHD.
Current clinical topics in cystic fibrosis
Authors: Tj David
Journal: Journal of the Royal Society of Medicine (2009)

This supplement arises out of the 22nd one‐day meeting on cystic fibrosis (CF) organized by the Section of Paediatrics of the Royal Society of Medicine. The proceedings of the first 21 meetings, held between 1985 and 2007, were published as Supplements to the Journal of the Royal Society of Medicine, and can still be obtained from the RSM.1–21 This supplement is also available online at http://jrsm.rsmjournals.com. This most recent meeting, organized by Dr Ian Balfour‐Lynn, was held at the Royal Society of Medicine in London on 11 November 2008. We are grateful to Forest Laboratories UK Limited for their support.

As in the past, the programme was designed to cover topical practical issues that face those who care for children and adults with CF. The audience comprised a mixture of paediatricians, adult chest physicians, physiotherapists, dietitians, CF specialist nurses, pharmacists and community and primary care medical staff, reflecting the multidisciplinary approach to the modern management of CF.

Topics covered included contraception and pregnancy (Guy Thorpe‐Beeston), nebulizers (Nicola Collins), mechanical chest compressors, also known as vests (Leyla Osman), highlights from the 2008 North American CF Conference (Tom Hilliard and his CF team), the need or otherwise for iron supplementation (Wanda Kozlowska), the role of palivizumab, Penumovax and influenza vaccination (Anne Thompson), selected CF papers published in 2008 (Ian Balfour‐Lynn), a debate about the value of routine screening for diabetes (Dan Peckham in favour, Martin Walshaw against) and four presentations by trainees.

It is hoped that all these papers will be of immediate practical interest to all doctors who care for patients with CF. The next RSM CF meeting will be held on 3 November 2009.

I would like to draw readers' attention to one major development which has taken place during the last 12 months, a result of an enormous scanning and archiving exercise. The entire contents of all the previous JRSM CF supplements are now available online through the JRSM website and a link to PubMed. This represents a huge and probably unique resource for those working in the field of CF, comprising 181 papers on CF published between 1986 and 2008, demonstrating an array of advances in our understanding and approach, and including a number of definitive reviews of the subject unavailable elsewhere.

Finally, on a personal note, I would like to take this opportunity to thank Dr Brian Webb, formerly Consultant Paediatrician at Musgrove Park Hospital in Taunton, for it was he who introduced me to the RSM and first took me to Section of Paediatrics meetings, when I was a medical student. The Section's CF meetings and the JRSM CF supplements are a legacy of the seed which he sowed back in 1967. The Section's annual CF meetings now have a special section for presentations by trainees, which one hopes will provide the stimulation, support and encouragement which I and many others have received by attending RSM meetings.
FIRST-IN-CLASS ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR LCZ696 MODULATES THE DYNAMICS OF THE RENIN CASCADE AND NATRIURETIC PEPTIDES SYSTEM WITH SIGNIFICANT REDUCTION OF ALDOSTERONE EXPOSURE
Authors: Jonathan Mochel, Bryan F. Burkey, Martin Fink, Roberto Garcia, Mathieu Peyrou, Jerome Giraudel, Didier Renard, Meindert Danhof
Journal: Journal of the American College of Cardiology (2014)
Molecular Epidemiology of Tuberculosis
Authors: Peter F. Barnes, M. Donald Cave
Journal: New England Journal of Medicine (2003)

The ability to determine the genotype of Mycobacterium tuberculosis is changing our understanding of the dynamics of tuberculosis transmission. This review summarizes the methods of genotyping and explains how they can assist clinical management. These techniques can be used to evaluate tuberculosis-control programs and provide clues to the pathogenesis of tuberculosis infection.
Biopsy Techniques
Authors: Robert G. Phelps, Mark G. Lebwohl
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
That Intern Dream
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2006)

Ad Libitum21 February 2006That Intern DreamJack Coulehan, MDJack Coulehan, MDFrom Setauket, NY 11733.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-4-200602210-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I had the intern dream again last night,restored to white, but decades olderthan that group of docs I hadn't met.Halfway through, it seemed I keptclutching a fear so tight, my smile was tin.Nor had I seen a single patient yet.At midnight rumpled interns atecold spaghetti, bread and juice. From a seatacross the room, I scanned their faces,convinced they didn't know my hideous sin.In fact, I had never learned to puta tube in place, or make an incision.but which direction? The ... Author, Article, and Disclosure InformationAffiliations: From Setauket, NY 11733.Current Author Address: Jack Coulehan, MD, 4 Townsend Court, Setauket, NY 11733. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 February 2006Volume 144, Issue 4Page: 308KeywordsBreadFearResuscitation ePublished: 21 February 2006 Issue Published: 21 February 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Influence of Original Renal Disease on the Fate of Renal Allografts.
Authors: Earl Smith
Journal: Annals of Internal Medicine (1968)

s1 May 1968The Influence of Original Renal Disease on the Fate of Renal Allografts.Earl Smith, M.D., Ray W. Gifford Jr., M.D., F.A.C.P., Satoru Nakamoto, M.D., Ralph A. Straffon, M.D., Kenneth Tung, M.D., David C. Humphrey, M.D., F.A.C.P., Donald G. Vidt, M.D.Earl Smith, M.D.Search for more papers by this author, Ray W. Gifford Jr., M.D., F.A.C.P.Search for more papers by this author, Satoru Nakamoto, M.D.Search for more papers by this author, Ralph A. Straffon, M.D.Search for more papers by this author, Kenneth Tung, M.D.Search for more papers by this author, David C. Humphrey, M.D., F.A.C.P.Search for more papers by this author, Donald G. Vidt, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1183_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe results of 132 renal allotransplantations performed in 109 patients at the Cleveland Clinic between January 1963 and October 1966 were reviewed to test the hypothesis that patients with chronic glomerulonephritis, an immunologic disease, should reject transplanted kidneys more readily than patients with other types of renal disease. The 1- and 2-year survival rates for renal allografts obtained from living donors was 78% (18 or 23) and 56% (9 of 16), respectively, for patients with chronic glomerulonephritis compared with 25% at both 1 (2 of 8) and 2 (1 of 4) years for patients with chronic pyelonephritis. The 1-and 2-year... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1183-1183KeywordsChronic kidney diseaseGlomerulonephritisKidneysPyelonephritisRenal diseases Issue Published: 1 May 1968 PDF DownloadLoading ...
Management of Myeloma with Bisphosphonates
Authors: Régis Bataille
Journal: New England Journal of Medicine (1996)

Osteolytic lesions are a hallmark of multiple myeloma. At the time of diagnosis, most patients have bone lesions whose extent is directly related to the mass of the tumor. About 30 percent of patients also have hypercalcemia. Bone lesions and hypercalcemia are major causes of morbidity in these patients, causing asthenia, cachexia, bone pain, fractures, compression of the spinal cord, and renal insufficiency. Thus, the diagnosis and treatment of bone disease are essential to the care of patients with multiple myeloma.Unfortunately, the efficacy of treatment of the skeletal effects of multiple myeloma is very limited. Only patients who have . . .
Abstract 5244: The Heme binding protein HRG-1 controls pH and enhances the invasive potential of cancer cells
Authors: Fionola Fogarty, Jean O’ Keeffe, Rosemary O’ Connor
Journal: Cancer Research (2012)

Abstract The Heme regulated gene (HRG)-1 encodes a 16kD transmembrane protein that is induced by IGF-1 in transformed cells and is associated with the Vacuolar - (H+) ATPase (V-ATPase) protein complex. V-ATPases pump protons across the membrane of endosomal compartments or into the extracellular environment to regulate acidification. V-ATPase expression and activity at the plasma membrane of cancer cells has been associated with an invasive phenotype. We previously showed that HRG-1 is essential for V-ATPase activity in endosomal acidification, so therefore we hypothesised that HRG-1 may also regulate extracellular pH to enhance cancer cell invasion. To test this we investigated HRG-1 expression in phenotypically distinct cancer cell lines and investigated whether it is required for V-ATPase- mediated extracellular acidification. We found that in highly invasive and migratory cell lines HRG-1 and the a1 subunit of the V-ATPase are both expressed at the plasma membrane. In less-aggressive cancer cells and in non transformed cells HRG-1 is not expressed at the cell membrane, and is restricted to the endocytic pathway. To investigate whether HRG-1 is required for V-ATPase function at the plasma membrane we stably over-expressed HRG-1 (HA-HRG-1) and empty vector (HA-EV) in MCF-7 cells and measured proton extrusion. MCF-7/HA-HRG-1 cells exhibited a greater effect on lowering the pH of the extracellular milieu compared to empty vector control cells and also exhibited a concomitant increase in cytosolic pH. The observed extracellular pH change in MCF-7/HRG-1 cells could be suppressed by the V-ATPase inhibitor Bafilomyocin A, demonstrating that this effect is V-ATPase dependent. We also observed that the expression level and activity of matrix metalloproteinase-2, a pH dependent degrading protease whose expression can be correlated with metastatic potential, was increased in MCF-7/HA-HRG-1 cells compared with control cells. Taken together, our findings suggest that HRG-1 expression at the plasma membrane of cancer cells enhances V-ATPase activity and this facilitates cell migration and invasion. Thus HRG-1 may be a suitable cell surface target for selectively disrupting V-ATPase activity and the invasive potential of cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5244. doi:1538-7445.AM2012-5244