tbuckley/cabot-search huggingface dataset:
Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit
Authors: Alexander Gerbaulet, Claudia Wickenhauser, Julia Scholten, Katrin Peschke, Sebastian Drube, Hans-Peter Horny, Thomas Kamradt, Ronald Naumann, Werner Müller, Thomas Krieg, Claudia Waskow, Karin Hartmann, Axel Roers
Journal: Blood (2010)
Perspective Roundtable: Lethal Injection
Authors: Philip M. Rosoff
Journal: New England Journal of Medicine (2008)

To the Editor: I was deeply disturbed by the discussion, led by Gawande, on physicians and executions (Jan. 31 issue).1 Except for Truog's principled objection to capital punishment on moral grounds, it seems as if the participants were missing the point of the argument over the question of physician involvement in the legalized killing of human beings. As Denno notes, the adoption of the lethal-injection protocol 31 years ago as the preferred method for execution has led to the medicalization of a procedure that has been abandoned by all but a few modern industrialized nations. An examination of the history . . .
Correction: Phenacetin Consumption
Authors: THOMAS A. GONWA
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 November 1980Correction: Phenacetin ConsumptionTHOMAS A. GONWA, M.D.THOMAS A. GONWA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-5-784_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There is a typographical error in my paper in the August issue (1). On p. 250, in the fourth sentence under Results, 18.3 g of phenacetin (9 to 36 g) should be 18.3kgof phenacetin (9 to 36kg)....Reference1. GONWA T, CORBETT W, SCHEY H, and BUCKALEW V. Analgesic-associated nephropathy and transitional cell carcinoma of the urinary tract. Ann Intern Med. 1980;93:249-52. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS A. GONWA, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1980Volume 93, Issue 5 Page: 784-784 ePublished: 1 December 2008 Issue Published: 1 November 1980 PDF downloadLoading ...
Serum albumin is essential for in vitro growth of activated human lymphocytes.
Authors: H Polet, H Spieker-Polet
Journal: The Journal of Experimental Medicine (1975)

The effect of human plasma, the plasma protein fractions of Cohn, and crystallized serum albumin on the in vitro growth of human lymphocytes activated by concanavalin A (Con A) or bacterial lipopolysaccharide was compared. It was found that fraction V or serum albumin (SA) is essential for growth of activated T and B lymphocytes. The other plasma proteins have no effect. The growth response of Con A-activated T lymphocytes to increasing concentrations of SA is similar to the response to increasing equivalent concentrations of plasma suggesting but not proving that SA is the only growth-stimulating factor in plasma when added to a protein-free culture medium. The growth-promoting effect of SA is not due to the fatty acids or hormones bound to SA but is attributed to the albumin molecule itself or to a factor tightly bound to it. SA can also effectively replace plasma to stimulate proliferation of lymphocytes activated by allogeneic lymphocytes or purified protein derivative of tuberculin.
Toxic Epidermal Necrolysis Occurring in a Child
Authors: J. V. F. Catto
Journal: BMJ (1959)

BMIJUSH MEDICA,L JOURNAL are followed up for at least four months in cases in which the head of the worm is not recovered after treatment.Failure of treatment due to vomiting was encountered more often among those treated with mepacrine than with male fern.As vomiting in patients with T. soliuni infections may give rise to cysticercosis, treatment with mepacrine in such cases is best avoided.
The Current Status of Hematopoietic Cell Transplantation
Authors: Frederick R. Appelbaum
Journal: Annual Review of Medicine (2003)

Hematopoietic cell transplantation is the preferred therapy for a substantial proportion of patients with life-threatening diseases of the lymphohematopoietic system. Recent advances in donor identification, disease eradication, and supportive care measures have broadened the application of transplantation and improved outcomes. This article provides a brief review of the major clinical principles of transplantation and results achieved to date.
Information and intelligence for healthy populations
Authors: Rosalind Raine, Sylvia Godden, Martin McKee
Journal: BMJ (2006)

colleagues' study shows that additional problems are identified when patients use an agenda form and when doctors are trained to use such a form.These additional problems come with a price tag, owing to increased consultation time.Little and colleagues also found this. 4 The overall time per problem was unchanged: this was not a case of three problems being managed for the price of two, but three for the price of three.An increase in overall patient satisfaction was seen only in the smaller one of these trials, 4 and it is not known whether the slight delay affected the satisfaction of subsequent patients.The key issue will be the importance, to the patient or the doctor, of the additional problems or concerns uncovered by the intervention.If these problems were always going to be raised-presumably at a later consultation-then there has been an efficiency gain.This should manifest itself in a reduction in reattendances, though this outcome was not measured.There is a large pool of symptoms in the community which never reach medical attention. 7Patients judge the seriousness of their problems when choosing whether or not to consult, and they are usually right. 8 9Agenda forms may simply medicalise problems that would otherwise not rise above the threshold for consultation.This is not necessarily a bad thing, because the doctor may be able to explain the circumstances in which a similar problem would warrant medical attention.Perhaps the main benefit from agenda forms is allowing embarrassing problems to be voiced.Until the content of such forms is analysed, however, this must remain supposition and the potential value of agenda forms in routine clinical practice will not have been fully assessed.
Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction
Authors: Nick J R Blackburn, Tanja Sofrenovic, Drew Kuraitis, Ali Ahmadi, Brian McNeill, Chao Deng, Katey J Rayner, Zhiyuan Zhong, Marc Ruel, Erik J Suuronen
Journal: Biomaterials (2014)
Social Environment and Health
Authors: Chris Meuli
Journal: JAMA (1982)

<i>Social Environment and Health</i>is a compilation of lectures given by Dr Stewart Wolf at the University of Washington, Seattle, in 1979. In these lectures he attempted to describe and clarify the effects of social relationships on physical health and disease. He begins the book with a historical perspective on health and disease, and proceeds to elucidate along a phylogenetic progression how various organisms show adaptive behaviors to changing environments. In the second section of the book he reviews the extant literature on the effects of rapid social change on health and disease in terms of how it affects both the individual organism and society. In modern times, social structures and patterns have evolved rapidly, helping man to adapt to new circumstances. However, when the rate of change has outstripped this adaptation, man's internal mental and physical responses have become inappropriate, giving rise to the physiological diseases of civilization. Wolf
Bladder Diverticulum Simulating a Pelvic Metastasis on a Tc-99m HDP Bone Scan
Authors: KIM D. FARMER, LAURA R. GELLETT, GILLIAN C. VIVIAN, KATERINA FRANKLIN
Journal: Clinical Nuclear Medicine (2001)

Carcinoma of the prostate was diagnosed in a 74-year-old man. A Tc-99m HDP bone scan was performed as part of the initial staging process. The findings on the bone scan were normal except for an area of increased tracer uptake projected over the left sacroiliac joint, which was seen best on the anterior view. When this was investigated further, the findings of a plain radiograph were inconclusive. Computed tomography showed a large diverticulum projecting from the left side of the bladder; the tracer retained within this diverticulum had produced the findings on the bone scan.
Perioperative Outcomes of Robotic and Laparoscopic Simple Prostatectomy: A European–American Multi-institutional Analysis
Authors: Riccardo Autorino, Homayoun Zargar, Mirandolino B Mariano, Rafael Sanchez-Salas, René J Sotelo, Piotr L Chlosta, Octavio Castillo, Deliu V Matei, Antonio Celia, Gokhan Koc, Anup Vora, Monish Aron, J Kellogg Parsons, Giovannalberto Pini, James C Jensen, Douglas Sutherland, Xavier Cathelineau, Luciano A Nuñez Bragayrac, Ioannis M Varkarakis, Daniele Amparore, Matteo Ferro, Gaetano Gallo, Alessandro Volpe, Hakan Vuruskan, Gaurav Bandi, Jonathan Hwang, Josh Nething, Nic Muruve, Sameer Chopra, Nishant D Patel, Ithaar Derweesh, David Champ Weeks, Ryan Spier, Keith Kowalczyk, John Lynch, Andrew Harbin, Mohan Verghese, Srinivas Samavedi, Wilson R Molina, Emanuel Dias, Youness Ahallal, Humberto Laydner, Edward Cherullo, Ottavio De Cobelli, David D Thiel, Mikael Lagerkvist, Georges-Pascal Haber, Jihad Kaouk, Fernando J Kim, Estevao Lima, Vipul Patel, Wesley White, Alexander Mottrie, Francesco Porpiglia
Journal: European Urology (2014)
MPs say NHS consultants should not do private work
Authors: L. Beecham
Journal: BMJ (2000)

The British government should make it a “long term objective” that consultants in the NHS should not practise privately, says a report of the House of Commons health committee's inquiry into consultants' contracts.

Of the 23000 consultants in the NHS, 16000 do some private practice. Those on whole time contracts (58% of all consultants) must not receive more than 10% of their NHS salary from private practice. Those with a maximum part time contract (24%) receive 10/11 of the NHS salary and have no limit on their private earnings.

The …
An unusual complication of colitis: Emad El-Omar, Editor
Authors: T. Zimbwa, R. Owen, G. Thomas, R. Hargest, G. T. Williams
Journal: Gut (2010)

An 18-year-old man with a 13 month history of ulcerative coltis (UC) was admitted with a progressive history of worsening left-sided abdominal pain, diarrhoea, rectal bleeding and weight loss. UC had been diagnosed on flexible sigmiodoscopy and biopsies, which confirmed moderately active colitis to the point of insertion (distal descending colon). Initially he was commenced on mesalazine and steroids, but his disease remained active and azathioprine was introduced after 4 months. Despite this he continued to suffer active symptoms, and a colonoscopy was performed after 8 months. This demonstrated some improvement, with mildly active colitis evident to the sigmoid. The full extent of his colitis was not established as the procedure was limited to the sigmoid because of patient discomfort. Over the next 4 months his condition and blood tests gradually worsened to the point that he required admission.

On examination, he was feverish and tachycardiac. Abdominal palpation demonstrated a left lower quadrant “mass” and tenderness, but no guarding. Laboratory analysis identified a microcytic anaemia (haemoglobin 5.6 g/dl), normal white cell count, elevated platelet count (666×109/l), raised C-reactive protein (199 mg/l) and a low albumin (23 g/dl). An abdominal radiograph showed right-sided faecal loading.

He failed to improve, despite treatment with hydrocortisone and intravenously, and a CT scan of his abdomen and pelvis was requested (figure 1).
Malpractice Insurance and Medical Defense.
Authors: S. C. Dunham
Journal: JAMA (1905)

Hartford, Conn., July 14, 1905. <h3>To the Editor:</h3> —The discontinuance by the Travelers' Insurance Company of the insurance of physicians against the consequences of professional errors has been made the subject of comment in several recent numbers ofThe Journal. From what you have published it seems that you and your readers are under some misapprehension respecting the scope of physicians' and surgeons' liability insurance. In your editorial, April 1, you refer to it as insurance against malpractice suits. The opinion of the attorney-general of Iowa, to which reference is made inThe Journal, April 22, seems to involve a like error, and Mr. E. H. Merritt, in his interesting letter published in the same number, evidently understands that it was the purpose of the insurance to cover malpractice, defined by him as "bad professional treatment of disease from reprehensible ignorance or carelessness." The Travelers Insurance Company never issued a
An acid transporting enzyme in human gastric mucosa.
Authors: G Saccomani, H H Chang, A A Mihas, S Crago, G Sachs
Journal: Journal of Clinical Investigation (1979)

Isolation of a microsomal fraction from human gastric mucosa followed by density gradient centrifugation yielded a vesicular membrane preparation free of mitochondrial markers, containing a K+-activated, ouabain-insensitive ATPase with an activity of 20.7 mumol P1 released/mg protein per h. Sodium dodecyl sulfate gel electrophoresis showed that the human gastric membrane vesicles contained a major polypeptide of 110,000 daltons, which accounted for approximately or equal to 30% of the total protein stained and was phosphorylated by [gamma-32P]ATP and dephosphorylated in the presence of K+. Electron microscopy revealed the presence of vesicles with an average size of 0.13 micrometer in diameter. Addition of 0.65 microM ATP to this vesicular preparation resulted in the uptake of 17 nmol H+/mg protein which was dependent on the presence of K+. The gradient was dissipated by a combination of valinomycin and protonophore after consumption of the ATP. Incubation of fixed human fundic sections or human gastric biopsy with monospecific hog gastric membrane antibody followed by fluorescein-conjugated goat anti-rabbit gamma-globulin, showed fluorescent staining in the middle portion of the gastric glands. These data indicate that human stomach contains a H+ transport ATPase with characteristics similar to those established for lower species.
Recombinant interleukin 12 cures mice infected with Leishmania major.
Authors: F P Heinzel, D S Schoenhaut, R M Rerko, L E Rosser, M K Gately
Journal: The Journal of Experimental Medicine (1993)

Resistant C57BL/6 mice infected with Leishmania major are self-healing, whereas susceptible BALB/c mice fail to contain cutaneous infection and subsequently undergo fatal visceral dissemination. These disparate outcomes are mediated by dissimilar expansions of T helper type 1 (Th1) and Th2 CD4+ T lymphocyte subsets in vivo during cure and progression of disease. Because interleukin 12 (IL-12) has potent T cell growth and interferon gamma (IFN-gamma) stimulatory effects, we studied its effect on CD4+ T cell differentiation during murine leishmaniasis. Treatment with recombinant murine (rMu)IL-12 during the first week of infection cured 89% of normally susceptible BALB/c mice, as defined by decreased size of infected footpads and 1,000-10,000-fold reduced parasite burdens, and provided durable resistance against reinfection. Cure was associated with markedly depressed production of IL-4 by lymph node cells cultured with antigen or mitogen, but preserved or increased production of IFN-gamma relative to untreated mice. IL-4 and IFN-gamma mRNA associated with CD4+ T lymphocytes isolated from infected lymph nodes showed similar reciprocal changes in response to rMuIL-12 therapy. A single injection of anti-IFN-gamma monoclonal antibody abrogated the protective effect of rMuIL-12 therapy and restored Th2 cytokine responses. We conclude that rMuIL-12 prevents deleterious Th2 T cell responses and promotes curative Th1 responses in an IFN-gamma-dependent fashion during murine leishmaniasis. Since BALB/c leishmaniasis cannot be cured with rMuIFN-gamma alone, additional direct effects of IL-12 during T cell subset selection are suggested. Because rMuIL-12 is uniquely protective in this well-characterized model of chronic parasitism, differences in IL-12 production may underlie heterogenous host responses to L. major and other intracellular pathogens.
Tacrolimus ointment and skin carcinogenesis in the DMBA/TPA model in mice: reply from authors
Authors: Y. NIWA
Journal: British Journal of Dermatology (2004)

Journal Article Tacrolimus ointment and skin carcinogenesis in the DMBA/TPA model in mice: reply from authors Get access Y. NIWA Y. NIWA Niwa Institute for Immunology, 4‐4 Asahimachi, Tosashimizu, Kochi‐ken 787‐0303, Japan E‐mail: yniwa@lime.ocn.ne.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 6, 1 December 2004, Page 1276, https://doi.org/10.1111/j.1365-2133.2004.06290.x Published: 01 December 2004
Relation Between Serum 3-Deoxyglucosone and Development of Diabetic Microangiopathy
Authors: Hitomi Kusunoki, Satoshi Miyata, Takeshi Ohara, Bing-Fen Liu, Atsuko Uriuhara, Hiroshi Kojima, Kotaro Suzuki, Hiroyuki Miyazaki, Yumiko Yamashita, Kayo Inaba, Masato Kasuga
Journal: Diabetes Care (2003)

OBJECTIVE—3-Deoxyglucosone (3-DG), a highly reactive intermediate of the glycation reaction, has been suggested to contribute to the development of diabetes complications. To verify this hypothesis, we assessed the relation between serum 3-DG concentrations and the severity of diabetic microangiopathy in diabetic patients. RESEARCH DESIGN AND METHODS—We conducted a high-performance liquid chromatography assay to determine the serum 3-DG concentrations of 110 diabetic patients with different degrees of severity of diabetic microangiopathy and 57 age-matched control subjects. RESULTS—The fasting serum 3-DG level in diabetic patients was significantly (P &amp;lt; 0.001) higher than that in control subjects (353 ± 110 vs. 199 ± 53 nmol/l). The 3-DG levels were significantly (P &amp;lt; 0.001) elevated even in the diabetic patients showing normoalbuminuria (n = 62, 322 ± 79 nmol/l) compared with control subjects. The 3-DG levels were further elevated in the patients with microalbuminuria (n = 30, 383 ± 146 nmol/l) and overt proteinuria (n = 18, 410 ± 100 nmol/l) (P = 0.027 and P &amp;lt; 0.001 vs. normoalbuminuria group, respectively). This phenomenon was basically reproduced in a category of retinopathy. Furthermore, the diabetic patients with low nerve conduction velocity showed a tendency to display higher 3-DG levels. CONCLUSIONS—The present results show that the fasting serum 3-DG level is elevated in diabetic patients and that the patients with relatively higher 3-DG levels were prone to suffer from more severe complications, indicating a possible association of 3-DG with diabetic microangiopathy.
Patients and carers put their cancer journeys on to film and canvas
Authors: Annabel Ferriman
Journal: BMJ (2006)

Anne Wilson, whose photograph (below, top) portrays her daughter Katherine, who died of cancer at the age of 28, is one of the finalists in an art competition called Expressions of a Cancer Journey, organised by the pharmaceutical firm Eli Lilly. The photo shows Katherine with her father, John, who …
Apology in Medical Practice
Authors: Aaron Lazare
Journal: JAMA (2006)

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981. Modulation of Human Dendritic Cell Function Following Viral Vectors: Implications for Gene Therapy in Vaccination
Authors: Peng H. Tan, Giovanna Lombardi, Andrew J.T. George
Journal: Molecular Therapy (2005)

The use of genes to modify dendritic cell (DC) function is an attractive approach to treat many diseases; either using mature DCs (mDCs) to immunize patients, or immature DCs (iDCs) to induce tolerance. While viral vectors are efficient at transducing DCs, their effect on the phenotype and function of DCs is less well characterised. We have investigated the effect of transduction with a variety of viral vectors. We show that adenovirus (Ad), human immunodeficiency virus (HIV), equine anaemia virus (EIAV) and Moloney murine leukemia virus (MMLV) can upregulate co-stimulatory molecules and MHC class II expression on DC, as well as inducing production of Th1 and proinflammatory cytokines. Following transduction with these vectors, there is upregulation of dsRNA-triggered pathways which result in IFN/ production, an established component of innate antiviral immunity. In addition, the function of virally-infected DCs is altered; the ability of iDCs to stimulate a mixed lymphocyte reaction (MLR) was increased and ability of mDCs to stimulate a MLR was decreased. We have shown that viral transduction of mDC results in upregulation of the indoleamine 2,3-dioxygenase (IDO) enzyme, which downregulates T cell responsiveness. Inhibition of the activity of IDO blocks the reduction in the MLR seen with mDC following viral transduction, indicating that this enzyme is responsible for the modulation of mDC function. These data have important implications for the use of viral vectors in the transduction of DC.
Depressant effect of digoxin on atrioventricular conduction in man.
Authors: D R Ricci, A E Orlick, B A Reitz, J W Mason, E B Stinson, D C Harrison
Journal: Circulation (1978)

We examined the effect of chronically administered digoxin on atrioventricular (A-V) conduction in nine cardiac transplant recipients. We assessed A-V conduction by measuring the duration from the pacing stimulus to the onset of the QRS complex (S'R interval) and by determining the occurrence of Wenckebach periodicity during rapid atrial pacing. We made measurements during a control period and during a period of digoxin administration of up to 37 days. During the digoxin period, the cycle length at which Wenckebach block occurred was prolonged by 14% of the control value and the S'R interval was significantly prolonged at paced rates of 110 beats per minute and faster. After digoxin was discontinued, the Wenckebach periodicity and S'R interval returned to control values. Atropine and propranolol did not alter digoxin's effect on A-V conduction. We conclude that digoxin exerts a direct (or non-neurally mediated) depressant effect upon A-V conduction in man, although the stress of tachycardia is necessary to demonstrate the effect.