Azithromycin-induced Acute Interstitial Nephritis
Authors: George A. Mansoor
Journal: Annals of Internal Medicine (1993)

Letters1 October 1993Azithromycin-induced Acute Interstitial NephritisGeorge A. Mansoor, MD, Bernard J. Panner, MD, and Daniel B. Ornt, MDGeorge A. Mansoor, MDSearch for more papers by this author, Bernard J. Panner, MDSearch for more papers by this author, and Daniel B. Ornt, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-7_Part_1-199310010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Acute interstitial nephritis leads to acute renal failure and is usually secondary to drug therapy. We report a case of irreversible, biopsy-proven acute interstitial nephritis in a patient who had received only azithromycin [1].A 43-year-old man was treated for respiratory infection with azithromycin (250 mg/d for 9 days). Six weeks later he had microscopic hematuria and a serum creatinine level of 530 mol/L. In 10 days the creatinine level increased to 1141 mol/L. A renal ultrasound showed no abnormality. Cryoglobulin concentrations, antinuclear antibodies, complement level, cytomegalovirus and Toxoplasma antibodies, serum and urine protein electrophoresis, antibodies to ...References1. Schentag JJ, Ballow CH. Tissue-directed pharmacokinetics. Am J Med. 1991; 91(Suppl):5S-11S. Google Scholar2. Pusey CD, Saltissi D, Bloodworth L, Rainford DJ, Christie JL. Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy. Q J Med. 1983; 52:194-211. Google Scholar3. Rosenfeld J, Gura V, Boner G, Ben-Bassat M, Livni E. Interstitial nephritis with acute renal failure after erythromycin. Br Med J. 1983; 286:938-9. Google Scholar4. Jensen HA, Halveg AB, Saunmaki KI. Permanent impairment of renal function after methicillin nephropathy. Br Med J. 1971; 4:406. Google Scholar5. Galpin JE, Shinaberger JH, Stanley TM, Blumenkrantz MJ, Bayer AS, Friedman GS, et al. Acute interstitial nephritis due to methicillin. Am J Med. 1978; 65:756-65. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPrevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting ListAzithromycin-Induced, Biopsy-Proven Acute Interstitial Nephritis in an Adult Successfully Treated with Low-Dose CorticosteroidsThe acute interstitial nephritis induced by azithromycinAcute renal failure in CF patients chronically infected by the Liverpool epidemic Pseudomonas aeruginosa strain (LES)Recurrent Acute Interstitial Nephritis Induced by AzithromycinAcute Interstitial Nephritis Due to CefoperazoneComparative safety of the different macrolidesFLURITHROMYCIN-INDUCED ACTUE INTERSTITIAL NEPHRITISAzithromycin 1 October 1993Volume 119, Issue 7_Part_1Page: 636-637KeywordsAcute renal failureAntibodiesCreatinineDrugsFibrosisGranulomasNephritisRenal failureSarcoidosisUrine Issue Published: 1 October 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...