tbuckley/cabot-search huggingface dataset:
THE RECLAMATION OF USED ALCOHOL
Authors: D. S. Lamb
Journal: JAMA (1918)

<h3>To the Editor:</h3> —An article with this caption by Elizabeth Selden, superintendent of the Butterworth Hospital, Grand Rapids, Mich., appeared in the<i>Journal</i>of the Michigan State Medical Society, December, 1917, p. 499. Inferentially the article intimates that many institutions waste used alcohol that might be reclaimed with advantage and economy. If this is true, the article is timely and the information that it contains should be more widely published. The Army Medical Museum has been reclaiming used alcohol since its foundation in 1862. The process is simple enough—the evaporation by the heat of a steam coil, and condensation of the vapor by a cold water coil. The vapor that first comes over and is condensed usually gives a grade of 85; the grade then gradually falls; when it reaches 50 the process is stopped and the residue is discharged into the sewer. The still is in the open air,
Phosphatase and tensin homologue status in sporadic and Cowden syndrome-associated trichilemmomas: evaluation of immunohistochemistry and fluorescence<i>in situ</i>hybridization
Authors: W. Shon, M.M. Wolz, W.R. Sukov, C.N. Wieland, L.E. Gibson, M.S. Peters
Journal: British Journal of Dermatology (2014)

Journal Article Phosphatase and tensin homologue status in sporadic and Cowden syndrome‐associated trichilemmomas: evaluation of immunohistochemistry and fluorescence in situ hybridization Get access W. Shon, W. Shon Department of Pathology, Immunology, and Laboratory Medicine University of Florida College of Medicine Gainesville PO Box 100275 FL 32610 U.S.A Search for other works by this author on: Oxford Academic Google Scholar M.M. Wolz, M.M. Wolz Department of Dermatology Mayo Clinic RochesterMN U.S.A Search for other works by this author on: Oxford Academic Google Scholar W.R. Sukov, W.R. Sukov Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN U.S.A Search for other works by this author on: Oxford Academic Google Scholar C.N. Wieland, C.N. Wieland Department of Dermatology Mayo Clinic RochesterMN U.S.ADepartment of Laboratory Medicine and Pathology Mayo Clinic Rochester MN U.S.A Search for other works by this author on: Oxford Academic Google Scholar L.E. Gibson, L.E. Gibson Department of Dermatology Mayo Clinic RochesterMN U.S.ADepartment of Laboratory Medicine and Pathology Mayo Clinic Rochester MN U.S.A Search for other works by this author on: Oxford Academic Google Scholar M.S. Peters M.S. Peters Department of Dermatology Mayo Clinic RochesterMN U.S.ADepartment of Laboratory Medicine and Pathology Mayo Clinic Rochester MN U.S.A E‐mail: peters.margot@mayo.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 5, 1 May 2014, Pages 1201–1204, https://doi.org/10.1111/bjd.12827 Published: 01 May 2014
Comparison of jejunal mucosa in post-gastrectomy states, idiopathic steatorrhoea, and controls using the dissecting microscope and conventional histological methods
Authors: G. B. Scott, M. J. Williams, C. G. Clark
Journal: Gut (1964)

EDITORIAL SYNOPSIS Jejunal biopsies from 24 patients with various post-gastrectomy states were compared with those from control patients and patients with idiopathic steatorrhoea.Minor histological changes, such as shortening and thickening of the villi, were frequently encountered in the control subjects, but the dissecting microscope showed that these were related to variations in villous shape.Similar changes in the villi were found in the post-gastrectomy patients, leaf-shaped villi and ridge formation being more common than was thought.in villous structure has been assessed.
Teaching laparoscopic surgery Practice on live animal is illegal
Authors: P Byrne, C C Nduka, A Darzi, A Cameron
Journal: BMJ (1994)

Teaching laparoscopic surgeryPractise on live animals is illegal EDITOR,-There is increasing pressure on the royal colleges to introduce some form of accreditation and assessment of practical skills in minimally invasive surgery.This is partly driven by attention in the media to cases that have had an unfavourable outcome.There has never, however, been a demand for such accreditation in general surgical skills.Theoretically, a doctor who has never performed surgery can obtain a fellowship of the Royal College of Surgeons or membership of the Royal College of Obstetricians and Gynaecologists.
THE EARLY ADMINISTRATION OF VACCINE IN PNEUMONIA
Authors: W. H. Wynn
Journal: BMJ (1915)

VACCINE IN PNEUMONIA. [MARCIT T3, 19T3 bad any seriotus bad results, it is necessary to discontinue the treatment pro' ptly, in a small percentage of the cases, owing to the onset of the symnptoms which I shall now, wentiom, From experience I do not nowv place a patient on the- casein treatment unless I can see himi daily for a week, or unless I can be daily iniforrned of hiis condition by hiis medical attendant and haye tlhe urine ,sent to nme daily.I have met with unfavourable symptoms in abouit 20 per.cent. of cases.A feeling of great weaknbss-andc exbau-tion oceurs-in a few,' and it is then desirable to discontinue the treat6nent on this accouint.Others become meI4ally de-, pressed and irritable at,what tlhey consider a lharsh treat- ment, and -will not continue it.In a few it produces.dyspepsia, o: cliarrhoea, or constipation.But in *the majority of cases it can be followed quite easily.and witlout unfavourable symptoms.Wlhen it ca-nnot be taken the.diet of creamn eggs, custard, beef-tea, already.deseribed, may be recommended.Patients ivho are fond of the pleastures of the table anid like nice foods will probably regard the casein treatment ah .1noto1jous,or as one of my patients-expressed it, " not in'tQewsting."BVu-t many talie it readily anid withotut any odislike, and are delighted at the results as regards the sugar excretion.In the casein treatment just.described-- 1.The amounlt of carbohydrates in the foocd is reduced to the m-liniitim; 2. The total quantity of food is redcuced to a very small amount;, 3. The food is given in small quaLntities at frequtient intervals-every two hlours.I am inclined to believe that the last two points are of iuch importance in the success of the treatment.Kinowing the great pressure on the space in the BRITISH MEDICAL hURNTAL I have not added descriptions of cases.Such letailed accon.itsI hope to plublish later -in the .llcdicc'tCl)ooticle.)
Ethical Principles in Critical Care
Authors: John M. Luce
Journal: JAMA (1990)

Luce applies five principles of medical ethics -- beneficence, nonmaleficence, autonomy, disclosure, and social justice -- to issues that often arise in critical care medicine. These issues include medical decision making, informed consent, resuscitation, brain death and organ donation, withholding or withdrawing life support, and allocation of medical resources. Acknowledging that the nature of the intensive care environment makes applying ethical principles difficult, Luce urges physicians to carry out their obligations to serve the interests of their patients.
A NOTE ON THE SUGGESTED TUBERCULOUS ORIGIN OF GRANULOMA ANNULARE
Authors: F. PARKES WEBER
Journal: British Journal of Dermatology (1929)

Journal Article A NOTE ON THE SUGGESTED TUBERCULOUS ORIGIN OF GRANULOMA ANNULARE Get access F. PARKES WEBER, M.A., M.D., F.R.C.P F. PARKES WEBER, M.A., M.D., F.R.C.P Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 41, Issue 2, 1 February 1929, Pages 67–68, https://doi.org/10.1111/j.1365-2133.1929.tb09313.x Published: 01 February 1929
Unsuspected Purulent Pericarditis Detected by Gallium-67 Scanning
Authors: DAVID P. SHREINER, VENKATARAMAN KRISHNASWAMI, JUDITH H. MURPHY
Journal: Clinical Nuclear Medicine (1981)

A Ga-67 scan performed because of a suspected intraabdominal infection demonstrated marked pericardial uptake of the isotope instead, and thus provided the first clue to the diagnosis of purulent pericarditis. Susequent studies and surgery revealed an esophagopericardial fistula, gas in the pericardial sac, and purulent pericarditis casued by multiple bacteria. This report presents an unusual cause of pericardil uptake of Ga-67. The use of Ga-67 scanning to diagnose purulent pericarditis in the absence of typical clinical findings is illustrated.
The Nursing Workforce in an Era of Health Care Reform
Authors: David I. Auerbach, Douglas O. Staiger, Ulrike Muench, Peter I. Buerhaus
Journal: New England Journal of Medicine (2013)

The importance of registered nurses is expected to increase under health care reform. Thanks to a surge in RN graduates, predicted workforce shortages have not materialized. But some uncertainties still threaten the sufficiency of the workforce in the future.
Role of the Dependence Receptor DCC in Colorectal Cancer Pathogenesis
Authors: Patrick Mehlen, Eric R. Fearon
Journal: Journal of Clinical Oncology (2004)

More than a decade ago, the DCC (deleted in colorectal cancer) gene was proposed as a putative tumor suppressor gene. Data supporting this proposal included observations that one DCC allele was deleted in roughly 70% of colorectal cancers, some cancers had somatic mutations of the DCC gene, and DCC expression was often reduced or absent in colorectal cancer tissues and cell lines. Despite subsequent studies which have supported DCC's potential role as a tumor suppressor gene, the rarity of point mutations identified in DCC coding sequences, the lack of a tumor predisposition phenotype in mice heterozygous for DCC inactivating mutations, and the presence of other known and candidate tumor suppressor genes on chromosome 18q have raised questions about DCC's candidacy. Following its initial characterization, the DCC protein was identified as a transmembrane receptor for netrins, key factors in axon guidance in the developing nervous system. At first glance, the established role of DCC and netrin-1 during organization of the spinal cord could be viewed as a further challenge to the position that DCC inactivation might play a significant role in tumorigenesis. However, recent observations on DCC's functions in intracellular signaling have renewed interest in the potential contribution of DCC inactivation to cancer. In particular, data indicate that, when engaged by netrin ligands, DCC may activate downstream signaling pathways. Moreover, in settings where netrin is absent or at low levels, DCC can promote apoptosis. Here, we review DCC's candidacy as a tumor suppressor gene, with an emphasis on how recent molecular analyses of DCC have offered support for the notion that DCC may function as a tumor suppressor gene.
Image-based characterization of thrombus formation in time-lapse DIC microscopy
Authors: Nicolas Brieu, Nassir Navab, Jovana Serbanovic-Canic, Willem H. Ouwehand, Derek L. Stemple, Ana Cvejic, Martin Groher
Journal: Medical Image Analysis (2012)

The characterization of thrombus formation in time-lapse DIC microscopy is of increased interest for identifying genes which account for atherothrombosis and coronary artery diseases (CADs). In particular, we are interested in large-scale studies on zebrafish, which result in large amount of data, and require automatic processing. In this work, we present an image-based solution for the automatized extraction of parameters quantifying the temporal development of thrombotic plugs. Our system is based on the joint segmentation of thrombotic and aortic regions over time. This task is made difficult by the low contrast and the high dynamic conditions observed in vivo DIC microscopic scenes. Our key idea is to perform this segmentation by distinguishing the different motion patterns in image time series rather than by solving standard image segmentation tasks in each image frame. Thus, we are able to compensate for the poor imaging conditions. We model motion patterns by energies based on the idea of dynamic textures, and regularize the model by two prior energies on the shape of the aortic region and on the topological relationship between the thrombus and the aorta. We demonstrate the performance of our segmentation algorithm by qualitative and quantitative experiments on synthetic examples as well as on real in vivo microscopic sequences.
An Analysis of Vasomotor Phenomena (Faints) occurring in Blood Donors
Authors: H. Brown, P. McCormack
Journal: BMJ (1942)

The removal of two-thirds of a pint of blood for the Transfusion Service has little effect.on the majority of blood donors.A small group-about 5%-show certain vasomotor phenomena, which are commonly called " faints," although loss of consciousness is uncommon.
Implications of two newly opened ice rinks on an accident and emergency department
Authors: P Freeland
Journal: BMJ (1988)

Before any major dietary changes can be recommended it remains to be clarified which component(s) of milk are responsible.None the less, it seems advisable for adults to drink milk only in moderate quantities.We thank Professor K Villako for the idea of the study and associate professors M Uuskula for his help in collecting the material, T Sahi for advice and reading the manuscript, and L-M Tooding for statistical analysis.
CLINICAL FEATURES AND PRESENTING SYMPTOMS AND SIGNS OF FIBROMUSCULAR DYSPLASIA: A REPORT OF THE FIBROMUSCULAR DYSPLASIA PATIENT REGISTRY
Authors: Jeffrey W. Olin, James B. Froehlich, Xiaokui Gu, J. Michael Bacharach, Bruce Gray, Mark A. Grise, Soo Hyum Kim, Eva Kline-Rogers, Pamela D. Mace, Robert McBane, Heather L. Gornik
Journal: Journal of the American College of Cardiology (2011)
The Journal of the American Dietetic Association: Shifts to SI Units
Authors: EDWARD J. HUTH
Journal: Annals of Internal Medicine (1987)

Editorials1 June 1987The Journal of the American Dietetic Association: Shifts to SI UnitsEDWARD J. HUTH, M.D.EDWARD J. HUTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-6-906_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn editorial in our January issue (1) indicated thatJournal of the American Dietetic Associationwas among 13 journals planning to shift to SI units in clinical chemistry and hematology. That journal has formally introduced its shift with an article by its editor, Dr. Elaine R. Monsen (2), in its March issue. The article indicates the dates for a planned three-phase shift, comments on specific units, and reproduces the conversion tables that were published in an article by Dr. Donald S. Young (3) in our January issue....References1. HUTH E. The American shift to medical SI units [Editorial]. Ann Intern Med. 1987;106:149-50. LinkGoogle Scholar2. MONSEN E. The Journal adopts SI units for clinical laboratory values. J Am Diet Assoc. 1987;87:356-78. CrossrefGoogle Scholar3. YOUNG D. Implementation of SI units for clinical laboratory data: style specifications and conversion tables. Ann Intern Med. 1987;106:114-29. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD J. HUTH, M.D.Affiliations: Professional Journal Sector Committee American National Metric Council Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRepetitive PublicationDONALD S. COFFEY, Ph.D.Correction: Reference in Editorial Note on Repetitive Publication 1 June 1987Volume 106, Issue 6Page: 906-907KeywordsClinical chemistryHematology and oncology ePublished: 1 December 2008 Issue Published: 1 June 1987 PDF downloadLoading ...
Incidence, predictors, and economic impact of contrast induced nephropathy: results in 8,628 patients treated with percutaneous coronary interventions
Authors: Ioannis Iakovou, G. Dangas, A.J. Lansky, G. Mintz, D. Ashby, M. Losquadro, M. Guiry, N. Kipshidze, R. Brandwein, T. Limpijankit, J. Forman, I. Hjazi, G.W. Stone, M.B. Leon, R. Mehran
Journal: Journal of the American College of Cardiology (2002)
Triple Valve Replacement With Aortic Homografts
Authors: Edward B. Stinson
Journal: JAMA (1968)

The aortic valve homograft can now be adapted for use in either of the atrioventricular valve positions. A simple titanium strut covered with knitted fluorocarbon (Teflon) provides a frame to which the homograft valve is sutured prior to implantation. Patients requiring multiple heart valve replacement can be treated by tissue valve substitutes rather than with plastic prostheses. Only fresh aortic valve homografts are used because preserved or sterilized valve grafts tend to calcify and deteriorate. The patient with three aortic valve homografts shows normal results from postoperative catheterization and has heart sounds indistinguishable from those of a normal heart. Anticoagulants have been uneventfully discontinued.
LOWER EXTREMITY MUSCLE ONSET TIMES DURING THE TRANSITION FROM DOUBLE-LEG STANCE TO SINGLE-LEG STANCE IN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTED SUBJECTS
Authors: B Dingenen, L Janssens, S Claes, J Bellemans, F Staes
Journal: British Journal of Sports Medicine (2014)

Background Deficits in neuromuscular control are believed to increase re-injury risk after anterior cruciate ligament reconstruction (ACLR). Previous studies mainly focused on muscles at the operated knee, less on muscles around other joints of the operated and non-operated leg. Objective To evaluate lower extremity muscle onset times during the transition from double-leg stance to single-leg stance in ACLR and non-injured control subjects. Design Cross-sectional (retrospective). Setting Controlled laboratory study. Participants 20 ACLR subjects (15 females, 5 males), 23.1±13.9 months after ACLR and fully returned to their pre-injury sport, and 20 non-injured control subjects (15 females, 5 males) participated in the study. Both groups were matched for age, gender, weight, height and activity level. All ACL injuries were caused by a non-contact injury mechanism. Risk factor assessment A transition task from double-leg stance to single-leg stance with eyes closed was performed, using a single force plate and surface electromyography. Movement speed was standardized. Both legs of each subject were tested. Main outcome measurements Onset times of 10 lower extremity muscles were compared between groups and between legs within the same group. Significance was set at P&lt;.05. Results T he ACLR group showed significant delayed muscle onset times for gastrocnemius (P=0.40), peroneus longus (P=.022), vastus medialis (P=.007), gluteus medius (P=.035) and gluteus maximus (P=.001). No significant different muscle onset times were found between legs in the ACLR group (P&gt;.05). Conclusions Despite the full return to sport, ACLR subjects showed delayed muscle onset times during the transitional movement, not only around the knee, but also around the hip and ankle of both legs. Whether these deficits are a result or a pre-existing risk factor of the initial ACL injury remains unclear. Secondary prevention strategies should focus on the whole lower kinetic chain of both legs to improve neuromuscular control after ACLR.
Aspirin and coronary heart disease: findings of a prospective study.
Authors: E C Hammond, L Garfinkel
Journal: BMJ (1975)

<h3>Abstract</h3> While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as plasmids suffer from low HDR efficiencies in many cell types, as well as integration at unintended sites. In contrast, single-stranded DNA (ssDNA) donors can produce efficient HDR with minimal off-target integration. Here, we describe the use of ssDNA phage to efficiently and inexpensively produce long circular ssDNA (cssDNA) donors. These cssDNA donors serve as efficient HDR templates when used with Cas9 or Cas12a, with integration frequencies superior to linear ssDNA (lssDNA) donors. To evaluate the relative efficiencies of imprecise and precise repair for a suite of different Cas9 or Cas12a nucleases, we have developed a modified Traffic Light Reporter (TLR) system [TLR-Multi-Cas Variant 1 (MCV1)] that permits side-by-side comparisons of different nuclease systems. We used this system to assess editing and HDR efficiencies of different nuclease platforms with distinct DNA donor types. We then extended the analysis of DNA donor types to evaluate efficiencies of fluorescent tag knock-ins at endogenous sites in HEK293T and K562 cells. Our results show that cssDNA templates produce efficient and robust insertion of reporter tags. Targeting efficiency is high, allowing production of biallelic integrants using cssDNA donors. cssDNA donors also outcompete lssDNA donors in template-driven repair at the target site. These data demonstrate that circular donors provide an efficient, cost-effective method to achieve knock-ins in mammalian cell lines.
Adipocyte CREB Promotes Insulin Resistance in Obesity
Authors: Ling Qi, Maziyar Saberi, Erik Zmuda, Yiguo Wang, Judith Altarejos, Xinmin Zhang, Renaud Dentin, Susie Hedrick, Gautam Bandyopadhyay, Tsonwin Hai, Jerry Olefsky, Marc Montminy
Journal: Cell Metabolism (2009)
Ringer, Hartmann, and Their Solutions
Authors: Stephen M. Hanson
Journal: JAMA (1968)

To the Editor:—  As one burdened with the cares of a hospital blood bank, I was delighted to read in an article by Dr. Benjamin Rigor et al (203:399, 1968), that most of my problems could be solved by the use of a panacean nostrum called Hartmann's solution.  While every child above the age of 3 in Kentucky, where Dr. Rigor practices, may know what Hartmann's solution is, I was dismayed to find that I did not, nor did my associate. After vainly reading thru the article three times in search of a clue as to the composition of this magical juice, I went down to our pharmacy and had it looked up in a reference volume calledRemington's Pharmaceutical Sciences. It turns out that under its generic name Hartmann's solution is good old lactated Ringer's injection USP, PHI; and of the five alternative names listed, Hartmann's solution is
Effect of plasma exchange on blood viscosity and cerebral blood flow.
Authors: M M Brown, J Marshall
Journal: BMJ (1982)

The effects of plasma exchange using a low viscosity plasma substitute on blood viscosity and cerebral blood flow were investigated in eight subjects with normal cerebral vasculature. Plasma exchange resulted in significant reductions in plasma viscosity, whole blood viscosity, globulin and fibrinogen concentration without affecting packed cell volume. The reduction in whole blood viscosity was more pronounced at low shear rates suggesting an additional effect on red cell aggregation. Despite the fall in viscosity there was no significant change in cerebral blood flow. The results support the metabolic theory of autoregulation. Although changes in blood viscosity appear not to alter the level of cerebral blood flow under these circumstances, plasma exchange could still be of benefit in the management of acute cerebrovascular disease.