tbuckley/cabot-search huggingface dataset:
Psychopathology and Psychopharmacology
Authors: John F. Greden
Journal: JAMA (1973)

In 1867, Maudsley's<i>Physiology and Pathology of the Mind</i>stressed the need to search for a "material basis for mental activity." More than one hundred years later, despite burgeoning neuropharmacological research efforts, the "material basis" that Maudsley spoke of still has not been delineated. Thus, it is not surprising that members of the American Psychopathological Association chose to pause and reflect during their 62nd Annual Meeting and consider "psychopathology and psychopharmacology" as their main topic of discussion. This volume contains papers presented at that meeting. In the long-standing search for an etiological agent of schizophrenia, investigators have passed through various stages. Infectious agents were initially sought. Later, "auto-intoxicants," genetically induced psychotoxins, and autoimmune responses occupied researchers' attentions. In this era of hallucinogen synthesis, it is not surprising that "drug models of schizophrenia" occupy the entire first part of the book. Eight papers deal with drug-induced behavioral changes of LSD, anticholinergics,
Certification in Critical Care Medicine
Authors: John A. Benson, Leonard D. Hudson
Journal: Annals of Internal Medicine (1987)

Editorials1 March 1987Certification in Critical Care MedicineJOHN A. BENSON JR., M.D., LEONARD D. HUDSON, M.D.JOHN A. BENSON JR., M.D.Search for more papers by this author, LEONARD D. HUDSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-470_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNext November the American Board of Internal Medicine ABIM) will administer to qualified diplomates its first examination in critical care medicine. Certification of competence in critical care medicine is designed to improve the quality of medical care by recognizing excellence among internists who provide critical care. Certification in this field is not a requirement to provide critical care, and the Board's certificate does not confer privilege to practice.Late in 1983 the ABIM withdrew from participation in a joint examination to be administered with its partners in anesthesiology, pediatrics, and surgery for two reasons: the Board could no longer endorse... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Third Five-Year Survey of Fellows (by Examination) of the Faculty of Intensive Care, Australian and New Zealand College of AnaesthetistsEffects of a Medical Intensivist on Patient Care in a Community Teaching HospitalThe Training/Examination Programme in Intensive Care, Australian and New Zealand College of Anaesthetists: 2. ExaminationCertification in Critical Care: Why?GERALD N. OLSEN, M.D. 1 March 1987Volume 106, Issue 3Page: 470-470KeywordsAnesthesiologyCritical careHealth care qualityPediatric surgeryPediatrics Issue Published: 1 March 1987 PDF DownloadLoading ...
Surgical management of pulmonary hydatid cysts in children.
Authors: M Elburjo, E A Gani
Journal: Thorax (1995)

BACKGROUND--Hydatid disease is common in Libya with a prevalence of 2%. Surgery of pulmonary hydatid disease remains the best treatment and aims to remove the cyst or its remnants and obliterate the residual cavity. METHODS--Forty three consecutive patients under 15 years of age were investigated by plain chest radiography, ultrasonography of the abdomen, and indirect haemagglutination tests. At thoracotomy the parasite or its remnants were removed and the bronchial fistula sutured. RESULTS--All but four of the patients were discharged within 12 days. These four had had their large cavities obliterated by purse string sutures and developed air fluid levels with cavity reformation at the cyst site. They were treated conservatively by physiotherapy and antibiotics and remained in hospital for 2-3 weeks. There was only one recurrence after three years of follow up. CONCLUSIONS--Pulmonary hydatid cysts in children can be treated successfully by evacuation and obliteration. The methods described can also be applied to adults.
Acute-pancreatitis: a complication of beta-blockade.
Authors: P N Durrington, S A Cairns
Journal: BMJ (1982)

potential routes for a multisynaptic itch reflex from the substantia to the nucleus of the trigeminal nerve in the medulla.The transmission of nerve impulses that give rise to a spinal reflex may be blocked by local anaesthesia.Our patients have not complained of itch since we added a small amount of bupivacaine to our intrathecal heroin preparation (1-0 mg freeze-dried heroin and 0-25 mg bupivacaine plain in 1-0 ml saline; pH 6-183, specific gravity 1-004 at 37°C).On this evidence an enkephalinergic reflex may well provide a credible alternative to histamine release as an explanation for facial itching associated with intraspinal administration of opiates.The reflex might be relayed at a central level by a medullary itch centre having a close functional link with the spinal nucleus of the trigeminal nerve.
A national health research policy
Authors: D. Jenkins
Journal: BMJ (1988)

give no suggestion that opposed treatment is hazardous with respect to ischaemic heart disease, we agree with Professor Beaglehole's assertion that it is premature to recommend postmenopausal hormones to prevent cardiovascular disease.On the issue of selection bias we, like many of the studies, found a protective effect on all cause mortality.This was reflected across all mortality from specific causes with two exceptions: firstly, we found a slight (but non-significant) excess of cancer of the ovary, and, secondly, in contrast with the Walnut Creek study2 our data showed an excess ofdeaths attributed to suicide or suspected suicide.
CT Scan Demonstrating Air in the Right Ventricle
Authors: Kim Eagle, Ralph G. Oriscello, Michael E. Robertello
Journal: New England Journal of Medicine (1993)

Figure 1. CT Scan Demonstrating Air in the Right Ventricle. To increase the rate of infusion of an intravenous contrast agent, air was forced into a patient's intravenous bottle. Shortly afterward, the patient became dyspneic, diaphoretic, and hypotensive, and computed tomography demonstrated air in the right ventricle. The air was removed by aspiration through a Swan-Ganz catheter placed in the ventricle, and the patient's condition immediately improved. In the vast majority of instances, the amount of air is small and is not associated with symptoms.
Influence of variation in birth weight within normal range and within sibships on IQ at age 7 years: cohort study
Authors: T. D Matte, M. Bresnahan, M. D Begg, E. Susser
Journal: BMJ (2001)

<h3>Abstract</h3> <b>Objective:</b> To examine the relation between birth weight and measured intelligence at age 7 years in children within the normal range of birth weight and in siblings. <b>Design:</b> Cohort study of siblings of the same sex. <b>Setting:</b> 12 cities in the United States. <b>Subjects:</b> 3484 children of 1683 mothers in a birth cohort study during the years 1959 through 1966. The sample was restricted to children born at ≥37 weeks gestation and with birth weights of 1500-3999 g. <b>Main outcome measure:</b> Full scale IQ at age 7 years. <b>Results:</b> Mean IQ increased monotonically with birth weight in both sexes across the range of birth weight in a linear regression analysis of one randomly selected sibling per family (n= 1683) with adjustment for maternal age, race, education, socioeconomic status, and birth order. Within same sex sibling pairs, differences in birth weight were directly associated with differences in IQ in boys (812 pairs, predicted IQ difference per 100 g change in birth weight =0.50, 95% confidence interval 0.28 to 0.71) but not girls (871 pairs, 0.10, −0.09 to 0.30). The effect in boys remained after differences in birth order, maternal smoking, and head circumference were adjusted for and in an analysis restricted to children with birth weight ≥ 2500 g. <b>Conclusion:</b> The increase in childhood IQ with birth weight continues well into the normal birth weight range. For boys this relation holds within same sex sibships and therefore cannot be explained by confounding from family social environment. <h3>What is already known on this topic</h3> IQ at school age is linked to birth weight among low birthweight babies Some evidence suggests the association might also apply to children of normal birth weight <h3>What this study adds</h3> IQ at age 7 years is linearly related to birth weight among children of normal birth weight The relation was not due to confounding by maternal or socioeconomic factors IQ is also associated with differences in birth weight between boy sibling pairs but not girls
Prognostic significance of monosomal karyotype in higher risk myelodysplastic syndrome treated with azacitidine
Authors: R Itzykson, S Thépot, V Eclache, B Quesnel, F Dreyfus, O Beyne-Rauzy, P Turlure, N Vey, C Recher, S Boehrer, C Gardin, L Adès, P Fenaux
Journal: Leukemia (2011)
Book Review Clinical Anesthesiology By G. Edward Morgan and Maged S. Mikhail. 747 pp., illustrated. Norwalk, Conn., Appleton and Lange, 1991. $39.95. Dripps/Eckenhoff/Vandam Introduction to Anesthesia Eighth edition. Edited by David E. Longnecker and Frank L. Murphy. 495 pp., illustrated. Philadelphia, W.B. Saunders, 1992. $37.
Authors: Rod K. Calverley
Journal: New England Journal of Medicine (1992)
Family Studies in Patients with the Sleep Apnea-Hypopnea Syndrome
Authors: Rajat Mathur
Journal: Annals of Internal Medicine (1995)

Objective: To determine whether familial factors affect development of the sleep apnea–hypopnea syndrome and upper airway caliber. Design: A case–control study. Setting: Tertiary, referral clinical sleep laboratory. Participants: 51 first-degree relatives of patients with the sleep apnea–hypopnea syndrome and 51 controls matched for age, sex, height, and weight who were drawn at random from a family practice register. To avoid studying the familial nature of obesity, only relatives of index patients with body mass indices less than 30.0 kg/m2 were recruited. Measurements: Assessment of sleep-related symptoms; breathing, sleep, and oxygenation patterns on overnight polysomnograms; upper airway dimensions by acoustic reflection; and facial structure by lateral cephalometry. Results: More relatives of patients with the sleep apnea–hypopnea syndrome reported snoring (24 relatives compared with 7 controls; P < 0.001) and daytime sleepiness (28 relatives compared with 16 controls; P = 0.01). Relatives had more apneas and hypopneas per hour (median of 13/h [95% CI, 3 to 82/h] for relatives compared with median of 4/h [CI, 0 to 53/h] for controls; P < 0.001), more arousals from sleep (30/h [CI, 11 to 87/h] for relatives compared with 17/h [CI, 4 to 59/h] for controls; P <0.001), poorer sleep quality, and more oxygen desaturations. Relatives also had narrower upper airways with retroposed maxillae and mandibles and longer soft palates with wider uvulae. Conclusion: The sleep apnea–hypopnea syndrome has a strong familial component. The familial tendency may be caused by differences in facial structure.
Prevalence and Morbidity of Heart Block in Devon
Authors: D. B. Shaw, D. Eraut
Journal: BMJ (1970)

In a survey in the Exeter area 139 patients with some degrees of abnormal atrioventricular conduction were notified by 282 family doctors. Per 100,000 of the population the prevalence of second-degree and thrid-degree heart block was estimated to be 17.3, of complete block past or present 15.6, and of complete block at the time of survey 13.1. Heart block was commoner in men than women, the sex ratio being 1.4 to 1; its prevalence increased steeply with age, and the morbidity rate was less than that reported by others. If the morbidity figures quoted in this survey are representative of the general population, it reaffirms the policy that pacemakers should be recommended for selected patients only.
Straddling and displaced atrioventricular orifices and valves.
Authors: S Bharati, H A McAllister, M Lev
Journal: Circulation (1979)

This is an anatomic study of 96 hearts with straddling or displaced atrioventricular (AV) valves and orifices. In the complete form, both the annulus and the peripheral connections of either AV valve straddle a ventricular septal defect (VSD) and connect to both ventricles. In the annular form, only the annulus, and in the peripheral type only the peripheral connections of the valve are found in both ventricles. In displaced AV valve, the entire annulus and periphery of one AV valve are displaced into the opposite chamber. These anomalies are commonly seen in complete transposition with or without ventricular inversion, and in double outlet right or left ventricle. Straddling mitral valve is frequently seen in the Taussig-Bing heart. Any type of VSD may be associated with straddling tricuspid valve; however, they usually are of the AV canal type. Straddling and displaced AV valves should be differentiated from criss-cross hearts in which both AV valves are completely connected to oppositely placed ventricles.
The Vital Statistics of the War.
Authors: Charles Smart
Journal: JAMA (1898)

Washington, D. C., Nov. 12, 1898. <h3>To the Editor:</h3> —In a communication in theJournalof October 29 I directed attention to the unsubstantial basis on which an editorial writer in the<i>Philadelphia Medical Journal</i>made a demand, on behalf of the medical profession, for an explanation of the fact that the ratio of death from disease to death from all causes was greater in the Spanish War than in the Civil War. The pressure of official business was so heavy that I was unable to discuss the conclusion admissible from the figures given by the journal cited, or to give some statistics which I am confident would have been regarded with interest by the members of theAmerican Medical Association, but this I propose now to do. The statement was made that death from disease formed 66.6 per cent, of the total mortality in the War of the Rebellion
A Phylogenetic Fantasy: Overview of the Transference Neuroses
Authors: Toksoz Byram Karasu
Journal: JAMA (1987)

Without metapsychological speculations and theorizing—I had almost said phantasizing—we shall not get another step forward.<sup>1</sup> His "steps forward" got Freud into major controversies with regard to his dualistic metapsychology. This "phylogenetic fantasy," which Freud himself called "witch metapsychology," an obvious reference to Faust (we may call the witch to our help after all), may provide further arguments for dispensing with Freudian metapsychology. In fact, Freud himself, most likely for the same reason, did not want to publish it. But posthumously, after almost 70 years had gone by, Ilse Grubrich-Simitis, the editor for S. Fisher Verlag of all of Freud's editions in Germany, while looking through papers in an old trunk belonging to Michael Balint (a student and copatriot of Sandor Ferenczi), came upon a manuscript in Freud's handwriting, which turned out to be the draft of the lost 12th metapsychological study of 1915:<i>A Phylogenetic Fantasy</i>. With another six
Aspirin Therapy for Colorectal Cancer With <i>PIK3CA</i> Mutation: Simply Complex!
Authors: Charles S. Fuchs, Shuji Ogino
Journal: Journal of Clinical Oncology (2013)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2013.52.0080 Journal of Clinical Oncology - published online before print October 28, 2013 PMID: 24166520 Aspirin Therapy for Colorectal Cancer With PIK3CA Mutation: Simply Complex! Charles S. FuchsxCharles S. FuchsSearch for articles by this author , Shuji OginoxShuji OginoSearch for articles by this author Show More Dana-Farber Cancer Institute, Boston, MA https://doi.org/10.1200/JCO.2013.52.0080 First Page Full Text PDF Figures and Tables © 2013 by American Society of Clinical Oncology
Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo
Authors: S. Zuloaga-Salcedo, M. Castillo-Vazquez, E. Vega-Memije, O. Arellano-Campos, J.M. Rodríguez-Pérez, N. Pérez-Hernández, L. Domínguez-Soto, T. Hojyo-Tomoka, G. Vargas-Alarcón, J. Granados
Journal: British Journal of Dermatology (2007)
Chronic lymphocytic leukemia with 6q− shows distinct hematological features and intermediate prognosis
Authors: A Cuneo, G M Rigolin, R Bigoni, C De Angeli, A Veronese, F Cavazzini, A Bardi, M G Roberti, E Tammiso, P Agostini, M Ciccone, M Della Porta, A Tieghi, L Cavazzini, M Negrini, G Castoldi
Journal: Leukemia (2003)
Instability of Polymeric Skin Collagen in Osteogenesis Imperfecta
Authors: M. J. O. Francis, R. Smith, R. J. Bauze
Journal: BMJ (1974)

The structural polymeric collagen of the skin of 19 patients with osteogenesis imperfecta has been examined. In those with severe bone disease, who often have white sclerae, this collagen fraction is less resistant to depolymerization than that of age-matched controls, though the total amount is normal. In patients with less severe bone disease, whose sclerae are usually blue, the polymeric collagen may have normal stability but the total amount is reduced. These results suggest defective cross-linking of collagen in severe osteogenesis imperfecta.
Effects of Ouabain on Force of Contraction, Oxygen Consumption, and Metabolism of Free Fatty Acids in the Perfused Rabbit Heart
Authors: ARISTIDES G. GOUSIOS, JAMES M. FELTS, RICHARD J. HAVEL
Journal: Circulation Research (1967)

Isolated rabbit hearts were perfused with a suspension of red cells which assured adequate oxygenation. Ouabain added to the perfusate (2.8 x 10 -7 M final concentration) promptly increased the force of contraction and oxygen consumption of the hearts. These events appeared to occur simultaneously. The extraction ratio of palmitate-1- 14 C added to the perfusate (0.31) was not altered by ouabain. However, ouabain increased the oxidation of the extracted palmitate from an average of 34% to an average of 71% at the time intervals studied.
IMPLANTABLE CARDIOVERTER DEFIBRILLATOR IMPLANTATION AND DEGREE OF LEFT VENTRICULAR SCARRING PREDICT SURVIVAL IN PATIENTS WITH SEVERE ISCHEMIC CARDIOMYOPATHY
Authors: Deborah Kwon, Zoran B. Popovic, Ernesto Ruiz Rodriguez, Noreen T. Nazir, Carmel Halley, Randall C. Starling, Milind Y. Desai, Scott D. Flamm, Thomas Marwick
Journal: Journal of the American College of Cardiology (2011)
Daisy the Doctor, Dr Dose, Dr Grizzly, Dr Amelia Bedelia, and colleagues
Authors: Monica Lalanda, Juan Antonio Alonso
Journal: BMJ (2006)

The way children perceive the world is shaped by different factors. They can be strongly influenced from an early age. Many carers and teachers read books to children, and these might be their first encounter with a new subject. This can create certain expectations before children can have their own experiences. Books for small children about "going to the doctor" are popular, and many adults will use them to help their youngsters cope with any related anxiety. They are common in children's wards and waiting areas for clinics and surgeries. By the time many children see a doctor they may have already looked at a book about doctors. To our knowledge, there are no previous studies on books for children about doctors and hospitals and whether they present an accurate view. We looked at a series of books to investigate the image of doctors, their attitudes, and their jobs. We selected 14 books written in English. The selection process was based on common factors for choosing children's books: colourful and appealing look (figs 1⇓ and 2⇓); reasonable price (<£8 (€12; $15)); and easily available. #### Details of books for children about doctors included in the study
Severe combined immunodeficiency with natural killer-cell predominance: Abrogation of graft-versus-host disease and immunologic reconstitution with HLA-identical bone marrow cells
Authors: Lawrence J. Sindel, Rebecca H. Buckley, Sherrie E. Schiff, Frances E. Ward, George H. Mickey, Andrew T. Huang, Charles Naspitz, Hillel Koren
Journal: Journal of Allergy and Clinical Immunology (1984)
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
Authors: Menno F. Kielman, Maaret Rindapää, Claudia Gaspar, Nicole van Poppel, Cor Breukel, Sandra van Leeuwen, Makoto Mark Taketo, Scott Roberts, Ron Smits, Riccardo Fodde
Journal: Nature Genetics (2002)
High-technology cardiac procedures. The impact of service availability on service use in New York State
Authors: J. Blustein
Journal: JAMA (1993)

To study the impact of the in-hospital availability of three cardiac procedures (cardiac catheterization, bypass surgery, and angioplasty) on their use in patients during the period following acute myocardial infarction (AMI).Retrospective cohort study, based on a statewide hospital discharge abstract data set.Patients admitted with a principal diagnosis of AMI to New York State hospitals during March through June of 1986.The odds of utilizing each of the three services either during the initial admission for AMI or during the 6-month postdischarge interval. Odds ratios (ORs) were calculated comparing utilization in three groups of patients: those initially presenting to hospitals lacking all three services, those initially presenting to hospitals offering only cardiac catheterization, and those initially presenting to hospitals offering all three of the cardiac services. Odds were adjusted for age, sex, race, income, primary payer, severity of illness, and geographical distance to hospital.Relative to patients initially presenting to hospitals lacking all three services, patients initially presenting to hospitals offering only cardiac catheterization were more likely to undergo cardiac catheterization (OR, 3.57; 95% confidence interval [Cl], 3.03 to 4.22), but were not significantly more likely to undergo bypass surgery or angioplasty. Relative to patients initially presenting to hospitals lacking all three services, patients initially presenting to hospitals offering all three services were more likely to undergo cardiac catheterization (OR, 5.50; 95% Cl, 4.66 to 6.50), bypass surgery (OR, 2.52; 95% Cl, 1.95 to 3.24), and angioplasty (OR, 6.85; 95% Cl, 4.73 to 10.58).The availability of cardiac services in the hospital to which patients initially present strongly influences the likelihood of their use in the period following AMI.
Distribution system for aid in Haiti doesn't exist, says Bill Clinton
Authors: J. Zarocostas
Journal: BMJ (2010)

Despite the massive inflow of aid, large gaps still exist in meeting the vital needs of Haiti’s earthquake victims—with food, shelter, and medical supplies and personnel the most urgent, top United Nations officials told political and business leaders attending the annual World Economic Forum in Davos, Switzerland.

The former US president Bill Clinton told delegates on 28 January, “The distribution system just does not exist.” More distribution centres were urgently needed, along with hundreds of pick-up trucks to …