Severe Vitamin D Deficiency: A Prerequisite for Chronic Obstructive Pulmonary Disease Responsiveness to Vitamin D Supplementation?
Authors: Andrew Grey, Mark Bolland, Ian Reid
Journal: Annals of Internal Medicine (2012)

Letters19 June 2012Severe Vitamin D Deficiency: A Prerequisite for Chronic Obstructive Pulmonary Disease Responsiveness to Vitamin D Supplementation?Andrew Grey, MD, Mark Bolland, PhD, and Ian Reid, MDAndrew Grey, MDFrom University of Auckland, 1042 Auckland, New Zealand.Search for more papers by this author, Mark Bolland, PhDFrom University of Auckland, 1042 Auckland, New Zealand.Search for more papers by this author, and Ian Reid, MDFrom University of Auckland, 1042 Auckland, New Zealand.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-12-201206190-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The randomized, placebo-controlled trial reported by Lehouck and colleagues (1) found that vitamin D supplementation did not improve any of a series of clinically important outcomes over 1 year in patients with moderately severe chronic obstructive pulmonary disease (COPD). It adds to an expanding body of clinical trial evidence that vitamin D supplementation does not favorably alter outcomes for many of the diseases that have been associated with lower vitamin D levels in observational studies (2). Collectively, these emerging data raise significant doubts about the role of vitamin D in the pathogenesis and management of nonskeletal disease. ...References1. Lehouck A, Mathieu C, Carremans C, Baeke F, Verhaegen J, Van Eldere J, et al. High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med. 2012;156:105-14. [PMID: 22250141] LinkGoogle Scholar2. Grey A, Bolland M. Vitamin D: a place in the sun? [Editorial]. Arch Intern Med. 2010;170:1099-100. [PMID: 20625012] CrossrefMedlineGoogle Scholar3. Gold DR, Manson JE. Severe vitamin D deficiency: a prerequisite for COPD responsiveness to vitamin D supplementation? [Editorial]. Ann Intern Med. 2012;156:156-7. [PMID: 22250148] LinkGoogle Scholar4. Manson JE, Bassuk SS, Lee IM, Cook NR, Albert MA, Gordon D, et al. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials. 2012;33:159-71. [PMID: 21986389] CrossrefMedlineGoogle Scholar5. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. 2011;342:d2040. [PMID: 21505219] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Auckland, 1042 Auckland, New Zealand.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHigh Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease An Lehouck , Chantal Mathieu , Claudia Carremans , Femke Baeke , Jan Verhaegen , Johan Van Eldere , Brigitte Decallonne , Roger Bouillon , Marc Decramer , and Wim Janssens Severe Vitamin D Deficiency: A Prerequisite for COPD Responsiveness to Vitamin D Supplementation? Diane R. Gold and JoAnn E. Manson Severe Vitamin D Deficiency: A Prerequisite for Chronic Obstructive Pulmonary Disease Responsiveness to Vitamin D Supplementation? Diane R. Gold and JoAnn E. Manson Metrics 19 June 2012Volume 156, Issue 12Page: 904KeywordsCalciumChronic obstructive pulmonary diseaseClinical trial reportingClinical trialsConflicts of interestObservational studiesObstetrics and gynecologyPathogenesisVitamin DVitamin D deficiency ePublished: 19 June 2012 Issue Published: 19 June 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...