tbuckley/cabot-search huggingface dataset:
Consultations in Dermatology
Authors: E. DORINDA LOEFFEL
Journal: JAMA (1972)

This small, eloquent book rates the rare commendation of consultant's consultant. In a scholarly, terse, and stimulating manner it tackles 50 difficult diagnostic and therapeutic skin problems. Each disease is introduced by a brief case history with accompanying full-page, highly-magnified black and white photograph of excellent quality. Disease discussions are informative and practical, combining facts from basic science with proper academic management of clinical problems. Glimpses of dermatologic history and terminology appear along with imaginative word-pictures of skin, such as the "silvery and luxurient" scale of psoriasis and the "distinctive dark brickwork patterning" of acanthosis nigricans. Kindly concern is shown for the disfigurement and discomfort of skin diseases, which "take away from the enjoyment of life." For instance, smouldering cystic acne may lead to "feelings of isolation, resentment, and unhappiness" and factitial scars may be "autographs of the psychic trauma of adolescence," a "calling for help" from individuals who later
How Do Institutional Review Boards Apply the Federal Risk and Benefit Standards for Pediatric Research?
Authors: Seema Shah
Journal: JAMA (2004)

Federal regulations allow children in the United States to be enrolled in clinical research only when the institutional review board (IRB) determines that the risks are minimal or a minor increase over minimal, or that the research offers a prospect of direct benefit. Despite this reliance on IRBs, no data exist on how IRBs apply the risk and benefit categories for pediatric research.To determine how IRB chairpersons apply the federal risk and benefit categories for pediatric research.Telephone survey, conducted between May and August 2002 of 188 randomly selected chairpersons of IRBs in the Unites States. The survey consisted of 21 questions to assess the application of federal risk standards to research procedures, whether certain interventions offer a prospect of direct benefit to participating children, and the extent to which IRBs use the federal definition of minimal risk when categorizing the risks of research procedures in children.Responses regarding categorization of the risk level and direct benefits of pediatric research procedures.A single blood draw was the only procedure categorized as minimal risk by a majority (152 or 81%) of the 188 respondents. An electromyogram was categorized as minimal or a minor increase over minimal risk by 100 (53%) and as more than a minor increase over minimal risk by 77 (41%). Allergy skin testing was categorized as minimal risk by 43 IRB chairpersons (23%), a minor increase over minimal risk by 81 (43%), and more than a minor increase over minimal risk by 51 (27%). Regarding benefits, 113 chairpersons (60%) considered added psychological counseling to be a direct benefit, while participant payment was considered a direct benefit by 10% (n = 19).Application of the federal risk and benefit categories for pediatric research by IRB chairpersons is variable and sometimes contradicted by the available data on risks and the regulations themselves. To protect children from excessive risks while allowing appropriate research, IRB chairpersons need guidance on applying the federal risk and benefit categories and also need data on the risks children face in daily life and during routine physical or psychological tests.
Arylsulphatase ratios in epidermis: a marker for malignancy?
Authors: C.E. Orfanos, H. Roelfzema, P.D. Mier, Jose J.M.A. Hurk
Journal: British Journal of Dermatology (1979)

Journal Article Arylsulphatase ratios in epidermis: a marker for malignancy? Get access C.E. Orfanos, C.E. Orfanos Department of Dermatology, University of Cologne, 5, Cologne, West Germany and Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar H. Roelfzema, H. Roelfzema Department of Dermatology, University of Cologne, 5, Cologne, West Germany and Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar P.D. Mier, P.D. Mier Department of Dermatology, University of Cologne, 5, Cologne, West Germany and Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar José J.M.A. van den Hurk José J.M.A. van den Hurk Department of Dermatology, University of Cologne, 5, Cologne, West Germany and Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 100, Issue 5, 1 May 1979, Pages 591–592, https://doi.org/10.1111/j.1365-2133.1979.tb05586.x Published: 01 May 1979
The Food and Drug Administration’s Role in Promoting Consistent Labels for Generic Drugs
Authors: Jon D. Duke, Aaron S. Kesselheim
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Provision of screening for Down's syndrome
Authors: H S Cuckle, A R Ellis, J Seth
Journal: BMJ (1995)

while always maintaining highest medical standards.How best to achieve this will vary depending on local needs, interests, skills, and geography, and the only way forward is by dialogue, col- laboration, and cooperation.Departments that remain blinkered and defensive will not serve the community and are more likely to wither while their populations continue to be at risk.
Importance of Renal Artery Stenosis in Normotensive Patients
Authors: Aaron Spital
Journal: Annals of Internal Medicine (1993)

Letters15 November 1993Importance of Renal Artery Stenosis in Normotensive PatientsAaron Spital, MDAaron Spital, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-10-199311150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent review of atherosclerotic renovascular disease, Rimmer and Gennari [1] point out that hypertension is not a sensitive marker of renal artery stenosis. Several studies were cited showing that among normotensive persons undergoing angiography for nonrenal indications, an important minority have anatomically significant renal artery stenosis. The important issue here, however, is not whether renal artery stenosis can occur in the absence of hypertension, but rather whether renal artery narrowing can be severe enough to cause renal failure without raising blood pressure. In the study by Harding and colleagues [2], in which 15% of 1235 ...References1. Rimmer JM, Gennari FJ. Atherosclerotic renovascular disease and progressive renal failure. Ann Intern Med. 1993; 118:712-9. Google Scholar2. Harding MB, Smith LR, Himmelstein SI, Harrison K, Phillips HR, Schwab SJ, et al. Renal artery stenosis: prevalence and associated risk factors in patients undergoing routine cardiac catheterization. J Am Soc Nephrol. 1992; 2:1608-16. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBartter’s syndrome and captopril scintigraphy: a case report 15 November 1993Volume 119, Issue 10Page: 1054KeywordsAngiographyCreatinineHypertensionLesionsRenal arteriesRenal diseasesRenal failureStable coronary artery diseaseStenosisVascular diseases Issue Published: 15 November 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Liver disease in aids
Authors: Lee R. Brettman
Journal: Hepatology (1987)

Abnormal liver chemistries, unexplained fevers, or hepatomegaly prompted 36 liver biopsies on 34 patients with the acquired immunodeficiency syn-drome. The most common finding was the presence of hepatic granulomas, seen in 13 of the biopsy specimens. Eight of these granulomas were illdefined, and 5 were more clearly associated with mycobacterial disesse. Portal fibrosis and fatty infiltration were comon, but a paucity of significant inflammatory activity was seen despite elevated aspartate aminotransferase levels, perhaps related to the underlying imunoincompetent status. Other noteworthy histopathologic findings included 1 patient each with peliosis hepatitis and cryptococcal hepatitis. Electron-microscopic evidence of cytoplasmic tubular structures or viral particles were seen within the hepatocytes of 2 patients. It is concluded that a broad spectrum of hepatic histopathology may be seen in the acquired immunodeficiency syndrome, and that liver biopsy may be diagnostically valuable in the clincial investigation of such patients.
Prolonged Starvation--A Dangerous Procedure
Authors: J. Runcie, T. J. Thomson
Journal: BMJ (1970)

Experience with 18 obese patients who have undergone prolonged (60 days) therapeutic starvation shows that in general this is a safe procedure, but there are significant associated hazards, particularly a breakdown in electrolyte homoeostasis. The need for close biochemical control of such patients is stressed.
THE MEDICAL TREATMENT OF CHRONIC ULCERATIVE COLITIS (NONSPECIFIC)
Authors: BURRILL B. CROHN
Journal: JAMA (1924)

In discussing the treatment of the nonspecific form of chronic ulcerative colitis, it is essential primarily to emphasize the fact that these remarks do not cover or include the therapy of specific types of chronic colitis, such as amebic or dysenteric colitis, either of which is more successfully combated with more specific drugs or with a specific antidysenteric serum. Nor is the subject of mucomembranous or mucous colitis included within the limits of this discussion, for the origin and nature of the latter differs essentially in all its details from the type of ulcerative inflammation under consideration. This discussion of the treatment of colitis is based on experiences with twenty-nine cases, observed during the years 1921, 1922 and 1923. The medical treatment of chronic ulcerative colitis has in the past been rather haphazard. This is said in no spirit of criticism of our predecessors, nor in a manner in any
Divorced of reasoning
Authors: D. Spence
Journal: BMJ (2010)

<h3>Abstract</h3> Serology testing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is increasingly being used during the current pandemic of Coronavirus Disease 2019 (COVID-19). The clinical and epidemiologic utilities of antibody-based SARS-CoV-2 testing are under debate. Characterizing these assays helps to understand the disease and provides scientific basis for deciding how to best use these assays. The study assessed one chemiluminescent assay (Abbott COVID-2 IgG) and two lateral flow assays (STANDARD Q [SQ] IgM/IgG Duo and Wondfo Total Antibody Test). Validation included 113 blood samples from 71 PCR-confirmed COVID-19 patients and 1182 samples from negative controls with potential interferences/cross-reactions, including 1063 pre-pandemic samples. IgM antibodies against SARS-CoV-2 were detected as early as post-symptom onset days 3-4. IgG antibodies were first detected post-onset days 5-6 by SQ assays. The detection rates increased gradually, and SQ IgG, Abbott IgG and Wondfo Total detected antibodies from all the PCR-confirmed patients 14 days after symptom onset. Overall agreements between SQ IgM/IgG and Wondfo Total was 88.5% and between SQ IgG and Abbott IgG was 94.6% (Kappa = 0.75, 0.89). No cross-reaction with other endemic coronavirus infections were identified. Viral hepatitis and autoimmune samples were the main cross-reactions observed. However, the interferences/cross-reactions were low. The specificities were 100% for SQ IgG and Wondfo Total and 99.62% for Abbott IgG and 98.87% for SQ IgM. These findings demonstrate high sensitivity and specificity of appropriately validated antibody-based SARS-CoV-2 assays with implications for clinical use and epidemiological seroprevalence studies.
Industrial Marketing and Medical Ethics
Authors: E M Bricker
Journal: New England Journal of Medicine (1989)

The subject of industrial marketing and medical ethics has concerned thoughtful physicians and medical educators for several years. Medical-service companies that offer bonuses — cash or travel and lodging or both — for attendance at what are primarily events to promote their products are one cause for concern. Another is the active participation of physicians in promotional exercises for which they receive compensation. The American Surgical Association aimed a resolution at these practices in 1987:It is the opinion of the American Surgical Association that it is unethical for a surgeon to accept remuneration or material reward for participating in . . .
INCREASING THE SPECIFICITY IN THALLIUM MYOCARDIAL SCINTIGRAPHY USING A SEQUENTIAL STOCHASTIC DEFECT ANALYSIS
Authors: Michael L. Goris
Journal: Clinical Nuclear Medicine (1984)

In the usual quantitative methods of analysis, a Thallium myocardial perfusion study is classified in a binary fashion as normal or abnormal. We investigated the effect of two alternatives in combination. First, the binary classification is replaced by a stochastic approach in which one assumes that the degree of abnormality in the scintigraphic images is related to the probability for angiographic abnormalities. Second, defects in different locations in different projections are treated as separate and independent “symptoms”, whose sensitivity and specificity for any given magnitude varies for different coronary lesion combinations. The results indicate that the probabilistic approach fails to the extent that false positives and negatives are not restricted to cases with marginal probabilities. This is due in part to the lack of independence of the “symptoms” but indicates that an intractable residual of “errors” is not dependent on marginal calls. On the other hand, there is distinct gain in specificity, for particular outcomes. If the specificity in general is 79%, the specificity of a lesion combination suggesting LAD is 87%, or 98% for the combination Main left-RCA. We conclude that the sequential stochastic approach increases the reliability of the test but will require a correction for symptom dependence and will not overcome the problem of distribution abnormalities unrelated to anatomical coronary lesions.
Evaluating Telemedicine in the ICU
Authors: Erika J. Yoo
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3726: Sexual function following surgery with or without intracavitary vaginal brachytherapy for early stage endometrial carcinoma
Authors: Allison M. Quick, Leigh G. Seamon, Soledad Fernandez, Ritu Salani, Electra Paskett, Douglas Martin
Journal: Cancer Research (2010)

Abstract Objective: The purpose of this research study is to describe the effects of intracavitary vaginal brachytherapy (IVB) on sexual function and quality of life of women with early stage endometrial cancer. Methods: 156 women, ages 20-75, with FIGO stage I to II endometrial cancer from 2002-2007 treated with surgery alone or surgery and IVB were identified and mailed questionnaires. Quality of life and sexual function were measured using the previously validated European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, the Cervix Cancer module, and the Sexual function-Vaginal changes Questionnaire. Pertinent data from prior surgery and radiation treatments were abstracted. Fisher's exact tests were used to evaluate the association of the variables. Results: In total, 87 surveys (56%) were returned. 70 patients completed the survey, 17 in the IVB arm and 53 in the surgery alone arm. In general, the overall quality of life was excellent in both treatment arms, with few patients reporting anxiety, depression, pain, or limitations of activities of daily living. However, 12% of patients treated with IVB (2/17) reported difficulty controlling their bowels compared to 8% of surgery alone patients (4/53) (p=0.037) and 30% (5/ 17) vs. 13% (7/ 53) reported edema in one or both legs (p=0.040). 55% of respondents had not been sexually active in the previous month (11/17, 65% IVB and 27/52, 52 % surgery) (p=0.6). Of sexually active patients (45%, N=31), 43% of IVB (3/7) and 42% (11/26) of surgery alone patients complained of vagina dryness during sexual activity (p=0.935) and 29% (2/7) vs. 20 % (5/25) felt their vagina was short (p=0.635). While 29% in both cohorts reported vaginal tightness, 14% of patients in both treatment groups described intercourse as painful. Sexual activity was enjoyable for only 43% (3/7) of the IVB patients and 60% (17/28) of the surgery alone patients (p=0.549). Conclusions: Overall the quality of life of women with early stage endometrial cancer is excellent following surgery or IVB. Patients treated with IVB report more bowel toxicity and lower extremity edema. Patients in both treatment arms report similar vaginal changes that affect sexual function. It is anticipated that additional data from other institutions participating in the study will allow more definitive exploration of these issues. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3726.
Israeli shells killed three daughters of Palestinian gynaecologist, investigation finds
Authors: J. Siegel-Itzkovich
Journal: BMJ (2009)

The Israel Defense Forces has admitted that shells from one of its tanks unintentionally killed three daughters and a niece of the Palestinian gynaecologist Izzeldin Abuelaish, who was at home in the Gaza Strip on 16 January ( BMJ 2009;338:b213, doi:10.1136/bmj.b213).

Dr Abuelaish, who has worked for years …
A national survey of endoscopic mucosal resection for superficial gastrointestinal neoplasia
Authors: D. Heresbach, R. Kornhauser, J. Seyrig, D. Coumaros, C. Claviere, A. Bury, J. Cottereau, J. Canard, S. Chaussade, A. Baudet, A. Casteur, O. Duval, T. Ponchon
Journal: Endoscopy (2010)

Studies on endoscopic mucosal resection (EMR) are mostly based on data from centers with high expertise. We report the average EMR results in a national survey of consecutive patients in France.A 1-year survey was carried out to record immediate outcome data of all EMRs performed, regardless of lesion size or gastrointestinal location.Overall, 1335 EMRs in 1210 patients were reported by 241 of the 736 gastroenterologists who performed such procedures (33 %). Resections were done for upper gastrointestinal lesions in 125 cases (41 esophageal, 43 gastric, and 41 duodenal lesions), in 45 % of cases using specific EMR techniques such as ligation, cap, or traction. The technique for resecting the 1210 lower gastrointestinal lesions mostly consisted of saline-assisted polypectomy or EMR, with specific techniques used in only 2.2 %. En bloc resection was less common with esophageal (46 %) or duodenal (54 %) neoplasms than in the lower gastrointestinal tract (73 %); size also had some influence (53 % > 1 cm vs. 92 % ≤ 1 cm). The overall complication rate was 5.2 %; the rate was lower for lesions 1 cm or smaller (0.6 % vs. 4.6 %). Fifty-four early and 17 delayed complications were recorded, in 12 % of upper gastrointestinal and 4.6 % of colonic lesions. Surgery became necessary in 1.6 % for upper and 2.9 % for lower gastrointestinal neoplasms. No association was seen between physician EMR caseload and either en bloc resection rate or complication rate.EMR in general, especially saline-assisted polypectomy in the colon, appears to be reasonably safe even when performed by nonexperts. EMR for larger or for upper gastrointestinal lesions should probably be limited to high-volume centers.
Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis.
Authors: S Grabbe, M Steinert, K Mahnke, A Schwartz, T A Luger, T Schwarz
Journal: Journal of Clinical Investigation (1996)

Allergic contact dermatitis differs from most other immune reactions by its strict dose dependence during the elicitation phase. Moreover, almost all known contact allergens can also induce dose-dependent irritative dermatitis and in general only elicit allergic contact dermatitis in sensitized individuals when applied within a narrow dose range. Therefore, we hypothesized that elicitation of contact hypersensitivity (CHS) may require two signals, antigen-specific effector cell activation and a non-antigen-specific proinflammatory signal, both of which are provided by application of a sufficient dose of hapten. To dissociate these putative two signals, oxazolone-sensitized mice were ear challenged with a dose of the specific hapten which was too low to elicit CHS. At the same time, an unrelated hapten was applied in a conventional concentration to the same skin site. Whereas neither treatment alone elicited a significant CHS response, application of both compounds together resulted in a strong CHS response that was indistinguishable from that elicited by the full dose of the specific hapten. Upon coadministration of the irrelevant hapten, allergic contact dermatitis could be elicited even when the dose of the specific hapten was further reduced by a factor of 10(3). In contrast, a dose reduction of the irrelevant hapten by a factor of two resulted in the loss of the CRS response. These data indicate that non-antigen-specific effects of epicutaneously applied haptens significantly contribute to the elicitation of CHS responses and that the capacity of the hapten to evoke this proinflammatory stimulus rather than its antigenicity is responsible for the strict concentration dependence.