Interaction between Simvastatin and <scp>l</scp>-Thyroxine
Authors: Eldad Kisch, Hermil S. Segall
Journal: Annals of Internal Medicine (2005)

Letters4 October 2005Interaction between Simvastatin and l-ThyroxineEldad Kisch, MD and Hermil S. Segall, MDEldad Kisch, MDFrom Le'umi Sick Fund, Tel Aviv, Israel.Search for more papers by this author and Hermil S. Segall, MDFrom Le'umi Sick Fund, Tel Aviv, Israel.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-7-200510040-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Simvastatin and l-thyroxine are often prescribed together in clinical practice, and interaction between them has rarely been reported.Objective: To describe 2 cases of interaction between simvastatin and l-thyroxine.Case Report: Patient 1 is a 75-year-old woman who had had hypothyroidism for many years and whose condition was well-controlled with l-thyroxine, 800 µg/wk (thyroid-stimulating hormone [TSH] level, 2.26 µIU/L). She was taking alendronate, 10 mg/d, with calcium supplementation. On 19 December 2003, the patient began taking simvastatin, 10 mg/d, for high levels of low-density lipoprotein cholesterol. Gradually, she felt tired and had abdominal pain (due to ...References1. Demke DM. Drug interaction between thyroxine and lovastatin [Letter]. N Engl J Med. 1989;321:1341-2. [PMID: 2797109] CrossrefMedlineGoogle Scholar2. Williams RH, Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, eds. Williams Textbook of Endocrinology. 10th ed. Philadelphia: WB Saunders; 2002:444. Google Scholar Author, Article, and Disclosure InformationAuthors: Eldad Kisch, MD; Hermil S. Segall, MDAffiliations: From Le'umi Sick Fund, Tel Aviv, Israel.Acknowledgment: The authors thank patient 1 and her treating physician for supplying full medical data. They also thank the staff of the Ichilov Hospital Pharmacy, Tel-Aviv, for conducting a thorough search of the relevant literature on drug interaction.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLevothyroxine: Conventional and Novel Drug Delivery FormulationsEvaluating Thyroid Function Tests in Patients with Kidney DiseaseDiagnosis, Prevention, and Management of Statin Adverse Effects and Intolerance: Canadian Consensus Working Group Update (2016)Statins and thyroid-stimulating hormone concentrations in patients with type 2 diabetesLevothyroxine Malabsorption Induced by Diabetic Gastroparesis Exacerbated During Pregnancies: Effect of Intramuscular Levothyroxine Injections and Levothyroxine Soft Gel CapsulesHipotiroidismo primario: consideraciones para una buena utilización del tratamiento con levotiroxinaThe Risk for Significant Creatine Kinase Elevation with StatinsFenofibrate-induced rhabdomyolysis in a patient with chronic kidney disease: an unusual presenting feature of hypothyroidismCase 27. Thyroid DiseaseA Neuromuscular Approach to Statin-Related MyotoxicityStatin Adverse EffectsPseudomalabsorption de L-thyroxine: une forme de pathomimieSimvastatin induced rhabdomyolysis and an important clinical link with hypothyroidism 4 October 2005Volume 143, Issue 7Page: 547KeywordsHypercholesterolemiaHypothyroidismNephrectomyPatientsRenal failureStatinsThyroidThyroid-stimulating hormoneThyroxineVitamin D ePublished: 4 October 2005 Issue Published: 4 October 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...