tbuckley/cabot-search huggingface dataset:
Concurrent coxibs and anti-platelet therapy unmasks aspirin-exacerbated respiratory disease: Table 1–
Authors: Irina Bobolea, Rosario Cabañas, Jesús Jurado-Palomo, Ana Fiandor, Santiago Quirce
Journal: European Respiratory Journal (2013)

Concurrent coxibs and anti-platelet therapy unmasks aspirin-exacerbated respiratory diseaseTo the Editor:Aspirin-exacerbated respiratory disease (AERD) is a clinical tetrad of chronic hypertrophic eosinophilic sinusitis, nasal polyps, asthma and sensitivity to any medication that inhibits cyclooxygenase (COX)-1, namely aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) [1].
Single-Step Atrial Thrombus Exclusion and Internal Cardioversion of Atrial Fibrillation Via a Transesophageal Echocardiography Probe
Authors: Thomas Schimpf, Karl Mischke, Jurgita Plisiene, Pal Soos, Christian Knackstedt, Markus Zarse, Felix Gramley, Lajos Patonay, Veronica Molina, Bela Merkely, Peter Hanrath, Patrick Schauerte
Journal: Journal of the American College of Cardiology (2005)
A Listeria monocytogenes Pentapeptide Is Presented to Cytolytic T Lymphocytes by the H2-M3 MHC Class Ib Molecule
Authors: Pamela H Gulden, Philip Fischer, Nicholas E Sherman, Wei Wang, Victor H Engelhard, Jeffrey Shabanowitz, Donald F Hunt, Eric G Pamer
Journal: Immunity (1996)

Polymorphism of MHC class Ia molecules severely constrains vaccine development against intracellular pathogens. Antigen presentation by MHC class Ib molecules, which are generally conserved between different individuals, may circumvent this obstacle. Herein, we use tandem mass spectrometry to identify a Listeria monocytogenes pentapeptide antigen that is presented to T lymphocytes by the H2-M3 MHC class Ib molecule. The peptide contains N-formyl methionine at the N terminus and exclusively hydrophobic amino acids. Mice of the H-2 d, H-2 b,and H-2 k haplotypes respond to this peptide upon infection with Listeria monocytogenes. Identification of antigens presented by MHC class Ib molecules is feasible and may provide opportunities for relatively unrestricted vaccine development.
New health ministers back further debate on assisted suicide law
Authors: Z. Kmietowicz
Journal: BMJ (2012)

The debate on whether the law on assisted suicide should change was reignited after two new health ministers, Anna Soubry and Norman Lamb, suggested at the weekend that there was a case for reviewing the legislation.

In an interview with the Times , Soubry, the newly appointed undersecretary of state for health, said it was “ridiculous and appalling” that British people had to “travel abroad” to end their lives.1 She criticised the present law for criminalising assisted suicide with sentences of up to 14 years in prison and called for greater honesty over when people would be prosecuted for …
Bioavailability of Cadmium in Inexpensive Jewelry
Authors: Jeffrey D. Weidenhamer, Jennifer Miller, Daphne Guinn, Janna Pearson
Journal: Environmental Health Perspectives (2011)

We evaluated the bioavailability of Cd in 86 components of 57 jewelry items found to contain high levels of Cd (> 10,000 ppm) by X-ray fluorescence (XRF), using extractions that simulate mouthing or swallowing of jewelry items.We screened jewelry for Cd content by XRF. Bioavailability was measured in two ways. Items were placed in saline solution at 37°C for 6 hr to simulate exposures from mouthing of jewelry items. Items were placed in dilute hydrochloric acid (HCl) at 37°C for 6-96 hr, simulating the worst-case scenario of a child swallowing a jewelry item. Damaged pieces of selected samples were also extracted by both methods to determine the effect of breaching the outer plating on bioavailability. Total Cd content of all items was determined by atomic absorption.The 6-hr saline extraction yielded as much as 2,200 µg Cd, and 24-hr dilute HCl extraction yielded a maximum of > 20,000 µg Cd. Leaching of Cd in dilute HCl increased linearly over 6-96 hr, indicating potential for increasing harm the longer an item remains in the stomach. Damage to jewelry by breaching the outer plating generally, but not always, increased Cd release. Bioavailability did not correlate directly with Cd content.These results indicate the potential for dangerous Cd exposures to children who wear, mouth, or accidentally swallow high-Cd jewelry items.
The 'Aging Game'
Authors: Laura J. McVey
Journal: JAMA (1989)

STRIKING demographic changes have occurred during this century with the increase in the number and proportion of elderly in the US population. With the improvement in life expectancy, however, the elderly are experiencing more of the cumulative effects of multiple chronic diseases and disability. The growing needs of the aged population require the availability of more physicians with an active interest and commitment to geriatric care. Yet, numerous reports have documented a widespread negative attitude held by those in the medical profession toward aging and the care of the elderly.<sup>1-10</sup>Such biases may, in part, be due to the general societal negativity toward the aged and they may further reflect the traditional orientation of medical training, which emphasizes the management and cure of acute diseases to the neglect of a comprehensive approach to geriatrics/gerontology in medical school curricula.<sup>8</sup> In an effort to sensitize medical students to the problems
Scale of norovirus outbreak may have been exaggerated
Authors: Caroline White
Journal: BMJ (2008)

NHS organisations in England are playing down the extent of the current outbreak of norovirus infection.

The highly contagious infection, which causes acute vomiting and diarrhoea, has resulted in the closure of some hospital wards across the country, and the number of laboratory confirmed infections is at its highest since 2002.

But a spokeswoman for the Health Protection Agency said that this rise was partly due to the introduction of a more sensitive test for norovirus, which had been rolled out across all testing sites last year.

“The season did start uncharacteristically early this year, with a …
Reviews and Notes: Endocrinology: The Menstrual Cycle: Physiology, Reproductive Disorders, and Infertility
Authors: Malur Sairam
Journal: Annals of Internal Medicine (1994)

Literature of Medicine15 June 1994Reviews and Notes: Endocrinology: The Menstrual Cycle: Physiology, Reproductive Disorders, and InfertilityMalur SairamMalur SairamClinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-12-199406150-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Menstrual Cycle: Physiology, Reproductive Disorders, and InfertilityMichel Ferin, Raphael Jewelewicz, and Michelle Warren. 250 pages. New York: Oxford University Press; 1993. $59.95.The events that govern the menstrual cycle during a woman's life are among the most complex. This book highlights the current knowledge of the regulation of the coordinated steps in the menstrual cycle and is a welcome addition to the literature on reproductive medicine. Until now, it was a common practice to find this subject dispersed as chapters in textbooks or works devoted to broad areas such as endocrinology, reproduction, the pituitary gland, the ovary, or ... Author, Article, and Disclosure InformationAffiliations: Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1994Volume 120, Issue 12Page: 1056KeywordsEndocrinologyInfertilityMenstrual cycleOvariesOvulationPituitary glandReproductive endocrinologyReproductive physiologyResearch laboratoriesUterus ePublished: 15 August 2000 Issue Published: 15 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Majority of Viral-Cellular Fusion Transcripts in Cervical Carcinomas Cotranscribe Cellular Sequences of Known or Predicted Genes
Authors: Irene Kraus, Corina Driesch, Svetlana Vinokurova, Eivind Hovig, Achim Schneider, Magnus von Knebel Doeberitz, Matthias Dürst
Journal: Cancer Research (2008)

Integration of human papillomavirus (HPV) DNA into the host genome is a frequent event in cervical carcinogenesis and is reported to occur at randomly selected chromosomal sites. However, as the databases are being up-dated continuously, the knowledge based on sequenced viral integration sites also expands. In this study, viral-cellular fusion transcripts of a preselected group of 74 cervical carcinoma or cervical intraepithelial neoplasia grade 3 (CIN3) biopsies harboring integrated HPV16, HPV18, HPV31, HPV33, or HPV45 DNA were amplified by 3'-rapid amplification of cDNA ends PCR and sequenced. Consistent with previous reports, integration sites were found to be distributed throughout the genome. However, 23% (17 of 74) of the integration sites were located within the cytogenetic bands 4q13.3, 8q24.21, 13q22.1, and 17q21, in clusters ranging from 86 to 900 kb. Of note is that clusters 8q24.21 and 13q22.1 are within 1.5 Mbp of an adjacent fragile site whereas clusters 4q13.3 and 17q21 are >15 Mbp distant to any known fragile sites. It is tempting to speculate that as yet unknown fragile sites may be identified on the basis of HPV integration hotspots. No correlation between HPV type and specific integration loci was found. Of 74 fusion transcripts, 28 contained cellular sequences, which were homologous to known genes, and 40 samples contained sequences of predicted genes. In 33 fusion transcripts, both viral and cellular sequences were in sense orientation, indicating that the gene itself or upstream sequences were affected by integration. These data suggest that the influence of HPV integration on host gene expression may not be a rare effect and should encourage more detailed analyses.
Up-regulation of microRNA 506 leads to decreased Cl−/HCO3− anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis
Authors: Jesús M. Banales, Elena Sáez, Miriam Úriz, Sarai Sarvide, Aura D. Urribarri, Patrick Splinter, Pamela S. Tietz Bogert, Luis Bujanda, Jesús Prieto, Juan F. Medina, Nicholas F. LaRusso
Journal: Hepatology (2012)

Cl−/HCO Symbol anion exchanger 2 (AE2) participates in intracellular pH homeostasis and secretin-stimulated biliary bicarbonate secretion. AE2/SLC4A2 gene expression is reduced in liver and blood mononuclear cells from patients with primary biliary cirrhosis (PBC). Our previous findings of hepatic and immunological features mimicking PBC in Ae2 -deficient mice strongly suggest that decreased AE2 expression might be involved in the pathogenesis of PBC. Here, we tested the potential role of microRNA 506 (miR-506) — predicted as candidate to target AE2 mRNA — for the decreased expression of AE2 in PBC. Real-time quantitative polymerase chain reaction showed that miR-506 expression is increased in PBC livers versus normal liver specimens. In situ hybridization in liver sections confirmed that miR-506 is up-regulated in the intrahepatic bile ducts of PBC livers, compared with normal and primary sclerosing cholangitis livers. Precursor-mediated overexpression of miR-506 in SV40-immortalized normal human cholangiocytes (H69 cells) led to decreased AE2 protein expression and activity, as indicated by immunoblotting and microfluorimetry, respectively. Moreover, miR-506 overexpression in three-dimensional (3D)-cultured H69 cholangiocytes blocked the secretin-stimulated expansion of cystic structures developed under the 3D conditions. Luciferase assays and site-directed mutagenesis demonstrated that miR-506 specifically may bind the 3′untranslated region (3′UTR) of AE2 messenger RNA (mRNA) and prevent protein translation. Finally, cultured PBC cholangiocytes showed decreased AE2 activity, together with miR-506 overexpression, compared to normal human cholangiocytes, and transfection of PBC cholangiocytes with anti-miR-506 was able to improve their AE2 activity. Conclusion: miR-506 is up-regulated in cholangiocytes from PBC patients, binds the 3′UTR region of AE2 mRNA, and prevents protein translation, leading to diminished AE2 activity and impaired biliary secretory functions. In view of the putative pathogenic role of decreased AE2 in PBC, miR-506 may constitute a potential therapeutic target for this disease. (HEPATOLOGY 2012)
ERRATUM: INDEED IT WAS HYPERPARATHYROIDISM
Authors: GEORGE R. BROWN
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 December 1968ERRATUM: INDEED IT WAS HYPERPARATHYROIDISMGEORGE R. BROWN, M.D.GEORGE R. BROWN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-6-1332_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:If the answer to Question 564 on p. 806 of the October issue of the ANNALSis milk-alkali syndrome, how do you explain the hypercalciuria, which does not occur in this syndrome?... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 1425 Cambridge Dr., Idaho Falls, Idaho PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1968Volume 69, Issue 6Page: 1332-1333KeywordsHypercalcemiaHyperparathyroidism Issue Published: 1 December 1968 PDF downloadLoading ...
Anthony Brendan Field
Authors: Clive Kelly
Journal: BMJ (2005)

​ConsultantConsultant in neurological rehabilitation Newcastle upon Tyne 1996-2005 (b Manchester 1964; q Newcastle upon Tyne 1988; MRCP), d 24 March 2005.




Figure 1




Tony worked as a junior doctor across the north east and spent two years at the Queen Elizabeth Hospital in Gateshead as a medical registrar before finding his niche in neurological rehabilitation. He developed special skills in managing young disabled people and was particularly interested in the treatment of muscle spasticity. Tony was a Manchester United fan and enjoyed exploring and photographing the Lake District, but latterly had struggled with recurrent depression. After a prolonged period of hospitalisation he took his own life. He leaves a wife, Sue, and two children. A memorial service will be held at King's Hall, University of Newcastle upon Tyne, at 1 pm on 14 September.
High job vacancy rates in hospitals and nursing homes underpin poor care, says watchdog
Authors: Z. Kmietowicz
Journal: BMJ (2012)

One in six hospital services (16%) in England inspected by the health and social care services regulator in 2011-12 did not have enough staff, leading to poor drug management and record keeping.

The Care Quality Commission’s report on the state of care looked at all adult care sectors for the first time: the NHS, independent healthcare, dental care, and social care.1

It found that of 250 inspections of hospital services 40 (16%) failed to ensure that they had enough staff to provide a good service. Inspectors from the commission found wards running with high vacancy rates and staff being asked to do too many different roles at once, says the report.

A similar number of residential care homes (603 of 3771 inspected) also had inadequate staffing, while …
Sources of carbon for hepatic glycogen synthesis in the conscious dog.
Authors: M C Moore, A D Cherrington, G Cline, M J Pagliassotti, E M Jones, D W Neal, C Badet, G I Shulman
Journal: Journal of Clinical Investigation (1991)

To identify the source(s) of carbon for the indirect pathway of hepatic glycogen synthesis, we studied nine 42-h fasted conscious dogs given a continuous intraduodenal infusion of glucose, labeled with [1-13C]glucose and [3-3H]glucose, at 8 mg.kg-1.min-1 for 240 min. Glycogen formation by the direct pathway was measured by 13C-NMR. Net hepatic balances of glucose, gluconeogenic amino acids, lactate, and glycerol were determined using the arteriovenous difference technique. During the steady-state period (the final hour of the infusion), 81% of the glucose infused was absorbed as glucose. Net gut output of lactate and alanine accounted for 5% and 3% of the glucose infused, respectively. The cumulative net hepatic uptakes were: glucose, 15.5 +/- 3.8 g; gluconeogenic amino acids, 32.2 +/- 2.2 mmol (2.9 +/- 0.2 g of glucose equivalents); and glycerol, 6.1 +/- 0.9 mmol (0.6 +/- 0.1 g of glucose equivalents). The liver produced a net of 29.2 +/- 9.6 mmol of lactate (2.6 +/- 0.8 g of glucose equivalents). Net hepatic glycogen synthesis totaled 9.3 +/- 2.5 g (1.8 +/- 0.4 g/100 g liver), with the direct pathway being responsible for 57 +/- 10%. Thus, net hepatic glucose uptake was sufficient to account for all glycogen formed by both the direct and indirect pathways. Total net hepatic uptake of gluconeogenic precursors (gluconeogenic amino acids, glycerol, and lactate) was able to account for only 20% of net glycogen synthesis by the indirect pathway. In a net sense, our data are consistent with an intrahepatic origin for most of the three-carbon precursors used for indirect glycogen synthesis.
IMPACT OF SMOKING AND ALTERNATIVE ANTITHROMBOTIC STRATEGIES ON OUTCOMES OF PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: ANALYSIS FROM THE HARMONIZING OUTCOMES WITH REVASCULARIZATION AND STENTS IN ACUTE MYOCARDIAL INFARCTION (HORIZONS-AMI) TRIAL
Authors: Kenji Goto, Eugenia Nikolsky, Alexandra J. Lansky, Adriano Caixeta, Martin Fahy, George D. Dangas, Bernhard Witzenbichler, Giulio Guagliumi, Roxana Mehran, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2010)
Language from gesture
Authors: Sherman Wilcox
Journal: Behavioral and Brain Sciences (2004)

The hypothesis that language began as a multimodal, gestural complex finds support in data from spoken languages on the connection between intonation and gesture, as well as from the process by which intonation becomes codified into grammar. Also, data from signed languages show a similar process at work, in which gestural elements become incorporated as intonation and conventionalized as grammatical markers.
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy
Authors: Yubin Ge, Katherine M. LaFiura, Alan A. Dombkowski, Qing Chen, Scott G. Payton, Steven A. Buck, Sridevi Salagrama, Amy E. Diakiw, Larry H. Matherly, Jeffrey W. Taub
Journal: Leukemia (2007)
The Technique of Psychotherapy
Authors: J. MARTIN MYERS
Journal: American Journal of Psychiatry (1955)

are described in terms of the oral, anal, genital, and latency periods; and the development of the Oedipus complex, the id, ego, and super ego.The various mechanisms of ego defense are elaborated with simple understandable examples from everyday life or clinical material.The outline sug- gested for recording the personal history follows the traditional pattern, but the mental status examination is the rather elaborate and ponderous form recommended by Karl Menninger and is not one that is apt to be generally adopted.The chapter on child psychiatry is simply presented; various case histories are used suitably to exemplify the syndromes described in the text.The psychoneurotic and psychotic reactions are described adequately and in gen- eral there is more emphasis and elaboration of the psychotherapeutic approach to mental illness than is found in most of the standard texts.The mental illnesses associated with organic disease of the brain are, however, poorly defined and described, and the descriptions of the neuropathologic processes accompanying these inadequate and at times naive.As a text medical students and social work students may find this volume useful to them if the concepts formulated therein are developed and elaborated by their teachers in a clinical setting.
Diabetes and Pregnancy in South Carolina: Prevalence, Perinatal Mortality, and Neonatal Morbidity in 1978
Authors: Frances C Wheeler, Charles W Gollmar, Larry C Deeb
Journal: Diabetes Care (1982)

Through retrospective analysis of vital records and hospital discharge data, this study examines the prevalence of diabetes in pregnancy and diabetes-related perinatal mortality and neonatal morbidity in South Carolina in 1978. Diabetes was observed in 5.9/1000 deliveries. Diabetic natality rates for whitesand nonwhites were 5.1/1000 and 6.9/1000, respectively. In comparison with comprehensive screening programs, these rates suggest that more than half of all diabetic pregnancies in South Carolina are unrecognized. The overall diabetic perinatal mortality rate was 102 deaths/1000 deliveries, in contrast to the nondiabetic perinatal mortality rate of 25 deaths/1000 deliveries. The risk of perinatal mortality is greater for nonwhites (153 deaths/1000 deliveries) and for women on insulin (182 deaths/1000 deliveries). One-fourth of the pregnancies among nonwhite women on insulin resulted in fetal or neonatal death. Observed neonatal morbidity was high, with respiratory distress syndrome, hypoglycemia, infections, and congenital anomalies the most frequent complications reported. Documentation of assessment for other common neonatal complications was limited
Electronic data protection: procedures need drastic improvement
Authors: Damian Mole, Colin Fox, Giulio Napolitano
Journal: BMJ (2005)

EDITOR—Gulena et al are correct to challenge overzealous interpretation of data protection law in their questionnaire survey of patients' and visitors' views about having their names displayed in hospital.1 Measures taken by doctors to safeguard patient confidentiality, especially electronic records, are, however, severely deficient and fuel the concerns of those entrusted to police data security.

We invited 32 surgical trainees to complete a …
Adrenal Hemorrhage in the Newborn
Authors: Bernard S. Siegel
Journal: JAMA (1961)

A NEWBORN infant was presented recently with massive intra-abdominal hemorrhage. At abdominal exploration, the source of the bleeding was found to be the right adrenal gland. A review of the hospital records revealed only one similar case in the last 10 years. This entity is not formally discussed in the standard textbooks of pediatric surgery, and a review of the literature revealed only 10 previous survivals following massive adrenal hemorrhage in the newborn.' 7There are, however, many reported cases of adrenal hemorrhage in the newborn not presenting as an acute problem or massive hemorrhage.13Our second case is of this nature. With these factors in mind, it was felt worthwhile to add these 2 cases to the literature and to review the topic of massive adrenal hemorrhage in the newborn.  Report of Cases  Case 1.—  This male infant, born on Sept. 2, 1960, was the product of a
Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12.
Authors: P Panina-Bordignon, D Mazzeo, P D Lucia, D D'Ambrosio, R Lang, L Fabbri, C Self, F Sinigaglia
Journal: Journal of Clinical Investigation (1997)

Interleukin 12 (IL-12) plays a central role in the immune system by skewing the immune response towards T helper 1 (Th1) type responses which are characterized by high interferon-gamma and low IL-4 production. In this report we present evidence that beta2-agonists inhibit IL-12 production by both human monocytes in response to lipopolysaccharide (LPS) and dendritic cells stimulated via CD40. Inhibition of IL-12 production is selective, as other cytokines produced by monocytes are unaffected. IL-12 inhibition is dependent on beta2-adrenoceptor stimulation and correlates with increased levels of intracellular cAMP. In conjunction with their ability to suppress IL-12 production, when beta2-agonists are added at priming of neonatal T lymphocytes, they inhibit the development of Th1-type cells, while promoting T helper 2 (Th2) cell differentiation. Further, the in vivo administration of a therapeutic dose of salbutamol results in the selective inhibition of IL-12 production by whole blood lymphocytes stimulated in vitro with LPS. These findings provide new insight into the immunological consequences of the clinical use of beta2-agonists and may suggest new approaches for the treatment of Th1-mediated diseases.