Hepatitis and Propylthiouracil
Authors: LAWRENCE N. PARKER
Journal: Annals of Internal Medicine (1975)

Letters1 February 1975Hepatitis and PropylthiouracilLAWRENCE N. PARKER, M.D.LAWRENCE N. PARKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-2-228_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDrugs of the thioamide type, introduced during the 1940s for the treatment of thyrotoxicosis, were occasionally noted to produce jaundice. This effect was noted mostly with thiouracil, methylthiouracil, and thiobarbital (1). Due to this and other toxicities, antithyroid therapy with two newer thioamides, propylthiouracil and methimazole, has replaced the earlier drugs. However, a case of severe hepatitis and jaundice temporally associated with propylthiouracil administration, and regressing with cessation of propylthiouracil therapy has recently been encountered by the author.A 9-year-old girl was diagnosed as having Graves' disease evidenced by markedly thyrotoxic signs and symptoms, a diffuse goiter, an131I uptake...References1. VANDERLAANSTORRIE WV: A survey of the factors controlling thyroid function, with special reference to newer views on antithyroid substances. Pharmacol Rev 7:301, 1955 MedlineGoogle Scholar2. MOVITTGERSTLDAVIS EBA: Needle liver biopsy in thyrotoxicosis. Arch Intern Med 91:729, 1953 CrossrefGoogle Scholar3. BECKERGORDENROBBINS CPJ: Hepatitis from methimazole during adrenal steroid therapy for malignant exophthalmos. JAMA 206:1787-1789, 1968 CrossrefMedlineGoogle Scholar4. COLWELLSANDOLANG ADS: Propylthiouracil-induced agranulocytosis, toxic hepatitis, and death. JAMA 148:639, 1952 CrossrefMedlineGoogle Scholar5. VALENTINE F: In Vitro Methods in Cell-Mediated Immunity, edited by BLOOM BR, GLADE PR. New York, Academic Press, 1971 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAWRENCE N. PARKER, M.D.Affiliations: Department of Medicine Division of Endocrinology Harbor General Hospital Torrance, California 90509 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFulminant hepatic failure associated with propylthiouracil: A case report with treatment emphasis on the use of plasmapheresisEffect of hyperthyroidism and propylthiouracil treatment on liver biochemical testsFulminant Hepatic Failure Associated with PropylthiouracilThe incidence and clinical characteristics of symptomatic propylthiouracil-induced hepatic injury in patients with hyperthyroidism: a single-center retrospective studyHepatite por propiltiouracil: apresentação de dois casos com evoluções diversasSuccessful Outcome with Methimazole and Lithium Combination Therapy for Propylthiouracil-Induced HepatotoxicitySevere Hepatotoxicity on Beginning Propylthiouracil TherapyFifty Years of Experience with Propylthiouracil-Associated Hepatotoxicity: What Have We Learned?1Propylthiouracil-Lnduced Hepatic DamagePediatric Hepatic Drug ReactionsPropylthiouracil-Induced Fulminant Hepatitis: Case Report and Review of the LiteratureDrug-induced “Allergic hepatitis”Propylthiouracil HepatotoxicityThyroid DisordersNeonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracilPropylthiouracil-Induced Cholestatic JaundiceHepatitis Associated with Propylthiouracil TreatmentAntithyroid DrugsDrugs and Liver Disease: A Tabular Compilation of Drugs and the Histopathological Changes That Can Occur in the LiverHyperthyroidism in childhoodFulminant Hepatitis and Lymphocyte Sensitization Due to Propylthiouracil 1 February 1975Volume 82, Issue 2Page: 228-229KeywordsAdverse reactionsDrug therapyDrugsHepatitisHepatitis ASigns and symptomsToxicity ePublished: 1 December 2008 Issue Published: 1 February 1975 PDF downloadLoading ...