tbuckley/cabot-search huggingface dataset:
A case of myelodysplastic syndrome with erythroid hypoplasia associated with a familial translocation t(3;14)(p21.1;q24.1)
Authors: Günçağ Dinçol, Şükrü Öztürk, Şükrü Palanduz, Gülçin Tutkan, Naciye Yıldırım, Mesut Ayer, Serkan Güvenç
Journal: American Journal of Hematology (2006)

Myelodysplastic syndrome (MDS) with erythroid hypoplasia, a rare form of MDS, has not yet been clearly defined. We report here a 20-year-old woman with severe transfusion-dependent anemia and reticulocytopenia. White blood cells and platelet counts were normal. Bone marrow examination showed a low percentage of erythroid precursors (6%) and a marked dyserythropoiesis and dysmegakaryopoiesis. A diagnosis of MDS (refractory anemia according to the FAB classification) with erythroid hypoplasia was made. Cytogenetic analysis of the bone marrow and peripheral blood revealed a 46,XX,t(3;14)(p21.1;q24.1) translocation, which was confirmed by fluorescence in situ hybridization analysis. This translocation was detected in the apparently healthy younger brother, father, and aunt (father's sister) of the patient. Clonality of T cells in the patient was not confirmed by the polymerase chain reaction and heteroduplex temperature-gradient gel electrophoresis. IgM serology for B19 parvovirus was negative. Other conditions known to be associated with erythroid hypoplasia, such as thymoma, were not present. The patient failed to respond to immunosuppressive therapy (antithymocyte globulin and cyclosporin A). Administration of recombinant human erythropoietin improved her anemia. To our knowledge, this balanced translocation, namely t(3;14)(p21.1;q24.1), which is present both in the patient with MDS with erythroid hypoplasia and in the healthy members of the family, has not been defined previously. Am. J. Hematol., 2006. © 2006 Wiley-Liss, Inc.
Reply to Tomasz Drewa and Piotr Chlosta's Letter to the Editor re: Frans Debruyne, Arkadij A. Gres, Dmitrii L. Arustamov. Placebo-Controlled Dose-Ranging Phase 2 Study of Subcutaneously Administered LHRH Antagonist Cetrorelix in Patients with Symptomatic Benign Prostatic Hyperplasia. Eur Urol 2008;54:170–80
Authors: Frans Debruyne, Arkadij A. Gres, Dmitrii L. Arustamov
Journal: European Urology (2008)
Splenic blood flow measurements by Doppler ultrasound: a preliminary report
Authors: A. MANOHARAN, R. W GILL, K. A GRIFFITHS
Journal: Cardiovascular Research (1987)

Splenic blood flow and splenic volume were measured by Doppler and cross sectional ultrasound in 72 human subjects consisting of 61 patients with splenomegaly and 11 normal subjects. This non-invasive and relatively simple method yielded satisfactory results in 76% of the subjects studied; failures were due to obesity, debility, distorted vascular anatomy, and excessive gas in the stomach. These preliminary results suggest that the Doppler ultrasound technique is a practical clinical method for measuring splenic blood flow.
In Vivo Histology of Barrett’s Esophagus and Associated Neoplasia by Confocal Laser Endomicroscopy
Authors: Ralf Kiesslich, Liebwin Gossner, Martin Goetz, Alexandra Dahlmann, Michael Vieth, Manfred Stolte, Arthur Hoffman, Michael Jung, Bernhard Nafe, Peter R. Galle
Journal: Clinical Gastroenterology and Hepatology (2006)
The Health Gap: Medical Services and the Poor
Authors: Juliana Geran Pilon
Journal: JAMA (1976)

<i>The Health Gap</i>is not so much scholarly as it is rhetorical. Part I outlines eight models for studying health behavior, yet their explanatory value is not assessed. Articles in Part II contain commonplace findings like: "The poor are less inclined to take preventive measures, and delay longer in seeking medical care," or "The costs of illness are inequitably distributed among the income categories and hence may cause or increase impoverishment." Part III, which deals with "Community Involvement in Health Care Delivery," is largely rhetorical; we are told, at great length, that more efforts should be made to involve the poor in decisions relating to health planning. The major article in Part IV contains a very long list of recommendations: there should be (1) continued extension of methods for detecting illness among lower income people, (2) improved use of the school for detecting illness, (3) reorganization of emergency services of
Abstract 2138: Vinblastine acutely sensitizes hematopoietic cancers to Bcl-2 targeting drugs
Authors: Darcy J.P Bates, Christopher Lowrey, Alan Eastman
Journal: Cancer Research (2011)

Abstract Chronic lymphocytic leukemia (CLL) characteristically maintains high levels of the anti-apoptotic protein Bcl-2, thus protecting them from apoptotic death and leading to an accumulation of mature resting B cells. Many other hematopoietic malignancies including acute promyelocytic leukemia (APL) also depend upon Bcl-2 family proteins for survival, suggesting that Bcl-2 proteins are excellent targets for anti-cancer therapies. We have previously shown that some leukemia and lymphoma cell lines undergo rapid apoptosis (≤6 h) when incubated with the microtubule disrupting agent vinblastine. Several other cell lines undergo this rapid apoptosis when vinblastine is combined with various approaches that target the anti-apoptotic proteins Bcl-2 or Mcl-1. These approaches include incubation with ABT-737 that inhibits Bcl-2 and Bcl-X, and SCH727965 (dinaciclib) that inhibits CDK7/9, thereby inhibiting translation which results in rapid loss of Mcl-1. In this study, we have assessed the ability of these agents alone or in combination to induce apoptosis in freshly isolated CLL and APL cells. Incubation with vinblastine alone induced variable apoptosis within 6 h (5-60%). ABT-737 induced rapid and almost complete apoptosis in CLL and in 50% of APL cells ex vivo. However, when combined with vinblastine, a 10-fold lower concentration of ABT-737 was required to induce complete apoptosis. Dinaciclib alone also induced variable levels of apoptosis (5-90%), but again the combination with vinblastine induced extensive apoptosis at lower concentrations of both drugs. Normal peripheral blood mononuclear cells were resistant to single agent or combination treatments. Sensitivity to ABT-737, dinaciclib or vinblastine was independent of CD38 and ZAP70 status and previous clinical treatment (untreated or relapsed patients). These results suggest that combinations of vinblastine and ABT-737 or dinaciclib are more effective than single agent therapy. Furthermore, these combinations may overcome resistance to individual drug therapies in patients with CLL or APL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2138. doi:10.1158/1538-7445.AM2011-2138
Inactivation of LEF1 in T-cell acute lymphoblastic leukemia
Authors: Alejandro Gutierrez, Takaomi Sanda, Wenxue Ma, Jianhua Zhang, Ruta Grebliunaite, Suzanne Dahlberg, Donna Neuberg, Alexei Protopopov, Stuart S. Winter, Richard S. Larson, Michael J. Borowitz, Lewis B. Silverman, Lynda Chin, Stephen P. Hunger, Catriona Jamieson, Stephen E. Sallan, A. Thomas Look
Journal: Blood (2010)
THE SORPTION OF INFLUENZA VIRUS BY CHICKEN ERYTHROCYTES
Authors: Thomas P. Magill
Journal: The Journal of Experimental Medicine (1951)

Data are presented which indicate that the forces of attraction between influenza virus and chicken erythrocytes are governed by an orderly mechanism which effects a proportional distribution of virus between erythrocytes and suspending fluid. For a unit mass of erythrocytes, the ratio of combined (sorbed) virus to free (unsorbed) virus is sufficiently constant over a wide range of virus concentrations to indicate compliance with the laws of mass action, or, perhaps, with the laws of simple adsorption; however, the ratio of combined (sorbed) virus to free (unsorbed) virus appears to be a parabolic function of the total quantity of virus.
Changing frequency of thiuram allergy in healthcare workers with hand dermatitis
Authors: K.L. Gibbon, J.P. Mcfadden, R.J.G. Rycroft, J.S. Ross, S. Chinn, I.R. White
Journal: British Journal of Dermatology (2001)

Healthcare workers (clinical, allied/paramedical professions and ancillary workers) may have prolonged contact with natural rubber latex devices, particularly in the form of natural rubber latex gloves.To examine the changing frequency of type IV thiuram allergy in healthcare workers with hand dermatitis over a 16-year period.During the study period, 450 healthcare workers (352 women and 98 men) with hand dermatitis were investigated, and their patch test results were analysed retrospectively.On average, a thiuram-positive patch test was noted in 12% of individuals, with a peak incidence of 27% of the patients patch tested in 1994. Comparison of results between 1983--88 and 1989--93 showed a statistically significant increase in the incidence of thiuram-positive patch tests (odds ratio 2.55, 95% confidence interval 1.25--5.20, P = 0.01).We have documented a changing frequency of thiuram-positive patch tests in healthcare workers with hand dermatitis since 1983. This may reflect changes in degree of exposure to thiurams in medical gloves during this period.
THE ETIOLOGY O EPITHELIOMA
Authors: ARTHUR E. HERTZLER
Journal: JAMA (1910)

<h3>I. THE DEVELOPMENT OF FIBROUS TISSUE</h3> The result of some studies in the development of fibrous tissue as observed in wound-healing from a necessary introduction to the consideration of the behavior of connective tissue in its relation to developing epithelium. It will be necessary, therefore, to present in outline some researches already published.<sup>2</sup> The first change in the healing of any wound is the exudation of a colorless serum. Within a few minutes this material begins to coagulate, forming bands extending from one wound surface to another. These bands become fully formed after a few hours. They take the direction most effectual for union. I speak of this process as coagulation because the fibers so formed stain by Weigert's fibrin stain and stain red by Mallory's stain, as is characteristic for fibrin (and Mallory's fibroglia fibrils), and because those things which prevent the coagulation of blood prevent the formation of these fibrils. We have then a tinctorial and
Restrictions on generic drugs "infringe the right to health"
Authors: P. Moszynski
Journal: BMJ (2010)

A free trade agreement currently being negotiated between the European Union and India threatens India’s production of cheap generic drugs, according to the UN special rapporteur on the Right to Health and other officials and campaigners.

Special rapporteur Anand Grover said in a 10 December press statement: “Millions in the developing world depend on India for generic medicines at affordable costs. Restriction of generic drug production in India will have a devastating public health impact around the world and adversely affect the right to health of millions of patients.”

He said that if the intellectual property provisions remain in the …
Treatment of acute venous thromboembolism with low molecular weight heparin (Fragmin). Results of a double-blind randomized study.
Authors: J Albada, H K Nieuwenhuis, J J Sixma
Journal: Circulation (1989)

We performed a prospective, randomized, double-blind trial in 194 unselected patients to determine the safety and efficacy of low molecular weight heparin (Fragmin) compared with standard heparin as the initial treatment of acute venous thromboembolism. Ninety-eight patients received continuous intravenous heparin, and 96 patients received Fragmin for 5-10 days. Doses were adjusted to maintain anti-Xa levels between 0.3 and 0.6 unit/ml for patients with a high risk for a bleeding complication and between 0.4 and 0.9 unit/ml for patients with a low risk for bleeding. Treatment was stopped when a therapeutic level of anticoagulation (International Normalized Ratio greater than 3.5) was reached with coumarins. Thirteen patients in the heparin group and 10 patients in the Fragmin group had a major bleeding complication. The incidence of major and minor bleeding complications combined decreased from 48.9% to 38.5% (95% confidence interval for the difference, -3.5% to +24.2%), corresponding with a relative bleeding risk reduction of 21.2%. There were no significant differences in efficacy as defined by new high-probability defects on repeat ventilation-perfusion scintigraphy of the lung in 80 patients: six of 46 patients in the heparin group and 3 of 34 patients in the Fragmin group had new defects (95% confidence interval for the difference, -9.4% to +17.8%). We conclude that low molecular weight heparin (Fragmin) given in adjusted, continuous, and intravenous doses is safe and effective as initial treatment of acute venous thromboembolism compared with heparin. There is a trend in risk reduction for bleeding in favor of low molecular weight heparin, a trend, however, that is smaller than expected compared with animal studies.
Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5
Authors: Takuhei Murase, Motoko Yamaguchi, Ritsuro Suzuki, Masataka Okamoto, Yumiko Sato, Jun-ichi Tamaru, Masaru Kojima, Ikuo Miura, Naoyoshi Mori, Tadashi Yoshino, Shigeo Nakamura
Journal: Blood (2006)
THE TOXICITY OF LARGE DOSES OF PENTAQUINE (SN-13,276), A NEW ANTIMALARIAL DRUG 1
Authors: Branch Craige, Lillian Eichelberger, Ralph Jones, Alf S. Alving, Theodore N. Pullman, C. Merrill Whorton
Journal: Journal of Clinical Investigation (1948)

This paper reports observations on the toxicity of pentaquine 8 when administered in amounts higher than the recommended therapeutic dose (1).The purpose of the observations was to define the margin of safety of the drug in clinical use.Pentaquine (SN-13,276) offers considerable promise as a radical cure of vivax malaria (1, 2).It is closely related chemically to pamaquin (Figure 1).At dosage levels within the therapeutic range, the drug has seldom caused serious toxic reactions in white subjects.We have reported therapeutic results in 88 patients treated with 60 mgm. of base per day for 14 days (2).Most of them had few or no symptoms; only two subjects had severe symptoms, but not such as to make discontinuance of medication advisable.Symptoms, when they occurred, were similar to those produced by pamaquin: methemoglobinemia, abdomi-
Richard Havel, Howard Eder, and the evolution of lipoprotein analysis
Authors: Scott M. Grundy
Journal: Journal of Clinical Investigation (2004)

In 1956, the JCI published a paper by Richard Havel, Howard Eder, and Joseph Bragdon on a method using an ultracentrifuge to physically separate plasma lipoproteins and chemical methods to analyze their lipid constituents. This paper has been much cited (7081 times as of this writing) in part because it represents a solid method that, with various modifications, has been applicable for the study of lipoproteins for almost half a century.
First-Pass or Single-Pass Radionuclide Angiography Evaluation of Left Ventricular Ejection Fraction Using a Microcomputer System
Authors: ROBERT E. DURNIN, ROBERT HENDERSON, DONALD LOGAN, DANIEL DANAHY, KAY BARRETT, TAMNIT ANSUSINHA
Journal: Clinical Nuclear Medicine (1979)

Left ventricular ejection fractions of 31 patients determined from first-pass or single-pass radionuclide angiography from the anterior position using a microcomputer system and floppy disc were compared to angiographic catheterization data obtained from the right anterior oblique position. This study demonstrated a good correlation with r = 0.91. To our knowledge, this is the first report of comparative first-pass left ventricular ejection fraction data and contrast angiography using a microcomputer system and a floppy disc.
1027 THE EFFECT OF DIETARY INTERVENTION ON THE LONG-TERM CLINICAL OUTCOME OF NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: R. Idilman, G. Seval, K. Çinar, D. Mizrak, Y. Bozkuş, M. Arslan, M. Bektaş, E. Erden, A. Özden
Journal: Journal of Hepatology (2009)
Let's talk about assisted dying
Authors: F. Godlee
Journal: BMJ (2009)

Two more people— the conductor Sir Edward Downes and his wife—travelled from the UK to Switzerland this week to die at a time (though surely not a place) of their own choosing. Their final journey to the Dignitas facility came just days after the House of Lords said no to providing immunity from prosecution for people who help relatives or friends travel abroad for an assisted suicide (doi:10.1136/bmj.b2797). The Lords’ decision followed a similar vote at the BMA’s Annual Representative Meeting last month ( BMJ 2009;339:b2699).

In an interview with the BMJ (doi:10.1136/bmj.b2868), Lord Falconer, the architect of the …
The Development of Medical Textbooks
Authors: William F. Keller
Journal: JAMA (1966)

<h3>To the Editor:—</h3> I was quite interested in the editorial "What's Wrong With Medical Textbooks?" (<b>197</b>: 291, 1966). Although I agree in general with the thesis of the editorial, there are some things which I believe ought to be considered in relation to some of the proposals that are put forth. At the outset let me say I would agree most textbooks currently available in medicine are, in reality, reference texts. At the same time, this relates to the market for medical "texts" since a majority of professors desire it. That is, they prefer not to have a short book which the student can follow, but rather to have a larger book to which he can refer. We and other publishers have experimented with short, succinct books which cover only the basic knowledge in a given area. Almost without exception these have been unsuccessful. I believe there are several reasons
Screening Healthy Infants for Iron Deficiency Using Reticulocyte Hemoglobin Content
Authors: Christina Ullrich
Journal: JAMA (2005)

ContextCurrent clinical practice relies on hemoglobin to detect iron deficiency, which misses infants not yet anemic and places them at higher risk for neurocognitive impairment. Reticulocyte hemoglobin content (CHr) has never been compared with hemoglobin for screening healthy infants.ObjectivesTo evaluate CHr for detecting iron deficiency without anemia in healthy 9- to 12-month-old infants and to compare CHr with hemoglobin in screening for iron deficiency in this population. A secondary objective was to explore the association between CHr and subsequent development of anemia.Design, Setting, and PatientsA prospective observational cohort study of 202 healthy 9- to 12-month-old infants from an urban, hospital-based, primary care clinic in Boston, Mass, who were screened for iron deficiency between June 2000 and April 2003, and followed up for a median of 5.6 months.Main Outcome MeasuresIron deficiency (transferrin saturation &lt;10%) and anemia (hemoglobin &lt;11 g/dL).ResultsOf 202 infants enrolled, 23 (11.4%) had iron deficiency and 6 (3%) had iron deficiency and anemia. Iron-deficient and non–iron-deficient infants had significantly different values for all measured hematological and biochemical markers for iron deficiency. Optimal CHr cutoff for detecting iron deficiency was 27.5 pg (sensitivity, 83% and specificity, 72%); a hemoglobin level of less than 11 g/dL resulted in a sensitivity of 26% and a specificity of 95%. Reticulocyte hemoglobin content was more accurate overall than hemoglobin was for detecting iron deficiency (area under the receiver operating characteristic curve, 0.85 vs 0.73; P = .007). A CHr of less than 27.5 pg without anemia at initial screening was associated with subsequent anemia when screened again in the second year of life (risk ratio, 9.1; 95% confidence interval, 1.04-78.9; P = .01).ConclusionsA CHr of less than 27.5 pg is a more accurate hematological indicator of iron deficiency compared with hemoglobin of less than 11 g/dL in these healthy 9- to 12-month-old infants. Further studies are warranted to determine whether CHr should be the preferred screening tool in the early detection of iron deficiency in infants.
Sustained virologic response rates with telaprevir by response after 4weeks of lead-in therapy in patients with prior treatment failure
Authors: Graham R. Foster, Stefan Zeuzem, Pietro Andreone, Stanislas Pol, Eric J. Lawitz, Moises Diago, Stuart Roberts, Paul J. Pockros, Zobair Younossi, Isabelle Lonjon-Domanec, Sandra De Meyer, Don Luo, Shelley George, Maria Beumont, Gaston Picchio
Journal: Journal of Hepatology (2012)
Relationship between Intrarenal Hydrostatic Pressure and Hemodynamically Induced Changes in Sodium Excretion
Authors: JOSEPH A. MARTINO, LAURENCE E. EARLEY
Journal: Circulation Research (1968)

Deep intrarenal venous pressure was used as an index of renal capillary pressure to test the proposal that physically induced changes in sodium reabsorption may be mediated by changes in Starling forces across the capillary. Renal vasodilatation produced natriuresis associated with immediate increases in intrarenal venous pressure. Increased arterial pressure was accompanied by further natriuresis and initially increased intrarenal pressure in vasodilated kidneys. Plasma load was always accompanied by increased intrarenal venous pressure. Saline loading usually increased intrarenal venous pressure, and restoration of plasma protein concentration during saline loading reduced, but did not abolish, natriuresis. This continued natriuresis was associated with reduced renal vascular resistance and increased intrarenal venous pressure, demonstrating that continued natriuresis after restoring plasma oncotic pressure during saline loading could relate to increased capillary hydrostatic pressure. Intrarenal venous pressure did not relate to isolated changes in urine flow, arterial pressure, or renal blood flow. These observations support the hypothesis that changes in peritubular capillary hydrostatic pressure initiate changes in tubular sodium reabsorption as a result of changes in capillary uptake.
Trauma services requirements in a district general hospital serving a rural area.
Authors: S J Kinny, D H Jones
Journal: BMJ (1990)

OBJECTIVE--To assess the demands made on a regional trauma centre by a district trauma unit. DESIGN--Two part study. (1) Prospective analysis of one month9s workload. (2) Retrospective analysis of one year9s workload by using a computer based records system. Comparison of two sets of results. SETTING--Accident unit in Gwynedd Hospital, Bangor. PATIENTS--(1) All patients who attended the accident unit in August 1988. (2) All patients who attended the accident unit in the calendar year April 1988-April 1989. MAIN OUTCOME MEASURE--Workload of a district trauma unit. RESULTS--In August 1988 there were 2325 attendances; 2302 of these were analysed. In all, 1904 attendances were for trauma; 213 patients were admitted to the trauma ward and 103 required an operation that entailed incision. Patients who attended the unit had a mean (range) injury severity score of 2-13 (0-25). Only two patients had injuries that a district general hospital would not be expected to cope with (injury severity score greater than 20). In the year April 1988-April 1989, 21,007 patients attended the unit. In all, 17,958 attendances were for orthopaedic injuries or injuries caused by an accident; 1966 patients were admitted to the unit. CONCLUSIONS--Most trauma is musculoskeletal and relatively minor according to the injury severity score. All but a few injuries can be managed in district general hospitals. In their recent report the Royal College of Surgeons has overestimated the requirements that a British district general hospital would have of a regional trauma centre.
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome
Authors: Iain Moore, Lisa Strain, Isabel Pappworth, David Kavanagh, Paul N. Barlow, Andrew P. Herbert, Christoph Q. Schmidt, Scott J. Staniforth, Lucy V. Holmes, Roy Ward, Lynn Morgan, Timothy H. J. Goodship, Kevin J. Marchbank
Journal: Blood (2009)