tbuckley/cabot-search huggingface dataset:
Fulminant fatal lupus erythematosus
Authors: K. Gudmundsen, B. Otridge, G.M. Murphy
Journal: British Journal of Dermatology (1992)

Journal Article Fulminant fatal lupus erythematosus Get access K. Gudmundsen, K. Gudmundsen Regional Centre of Dermatology Mater Misericardiae Hospital Dublin 7 Ireland Search for other works by this author on: Oxford Academic Google Scholar B. Otridge, B. Otridge Regional Centre of Dermatology Mater Misericardiae Hospital Dublin 7 Ireland Search for other works by this author on: Oxford Academic Google Scholar G.M. Murphy G.M. Murphy Regional Centre of Dermatology Mater Misericardiae Hospital Dublin 7 Ireland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 126, Issue 3, 1 March 1992, Pages 303–304, https://doi.org/10.1111/j.1365-2133.1992.tb00667.x Published: 01 March 1992
Abstract 5484: Simultaneous targeting of EGFR and MET pathways using nanotechnology improves the treatment outcomes of photodynamic therapy for pancreatic cancer
Authors: Lei Z. Zheng, Prakash Rai, Zhiming Mai, Bryan Q. Spring, Tayyaba Hasan
Journal: Cancer Research (2010)

Abstract Pancreatic Cancer (PanCa) is difficult to treat due to its inherent resistance to most therapies. First line chemotherapy only has a 5% response rate that yields a dismal prognosis of 6-month median survival and &amp;lt;4% 5-year survival. Combination therapies only showed modest benefits and there are still vital unmet needs for alternative treatment that improve overall patient survival. Photodynamic Therapy (PDT), a light-regulated cytotoxic therapy, showed promise as a new treatment modality for PanCa which improved median survival from 6 to 9.5 months in a pilot clinical trial. This result triggered our preclinical development of PDT combination regimen targeting proliferative pathways to further enhance treatment outcome. Using nanotechnology, we designed and synthesized nano-constructs co-encapsulating multiple therapeutic agents that can simultaneously target EGFR and MET-regulated proliferative pathways in combination with cytotoxic PDT treatment. We tested these nano-constructs in orthotopic pancreatic cancer models for treatment efficacy and our major findings include: 1) The nanoscale multidrug delivery system allows simultaneous targeting of EGFR and MET-regulated proliferative pathways and offered the best reduction of local tumor burden and metastatic burden to lymph nodes, lung and liver. With only one time of treatment, the local tumor burden is reduced to 10% of that of non-treated, and significant reductions of organ metastasis were also achieved. 2) The nanoscale multidrug delivery system delivers PDT agent and MET inhibitor PHA-665752 with higher payload and reduces their systemic toxicity. The EGFR inhibitor Cetuximab is delivered intracellularly into cancer cells, which targets both intracellular and cell surface EGFR. Intracellular delivery of Cetuximab increased treatment efficacy compared to naked Cetuximab. We are continuing optimizing the scheduling of individual treatments to further improve treatment outcomes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5484.
Will heroin eventually see the light of day for treating chronic pain?
Authors: B. J. Montgomery
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MiR-10b Downregulates the Stress-Induced Cell Surface Molecule MICB, a Critical Ligand for Cancer Cell Recognition by Natural Killer Cells
Authors: Pinchas Tsukerman, Noam Stern-Ginossar, Chamutal Gur, Ariella Glasner, Daphna Nachmani, Yoav Bauman, Rachel Yamin, Alon Vitenshtein, Noah Stanietsky, Tomer Bar-Mag, Dikla Lankry, Ofer Mandelboim
Journal: Cancer Research (2012)

Natural killer cells (NK) are a component of innate immunity well known for their potent ability to kill virus-infected or neoplastically transformed cells following stimulation of the NK cell receptor NKG2D. One of the various ligands of NKG2D is MICB, a stress-induced ligand that has been found to be upregulated on the surface of tumor cells. However, there is little knowledge about how this upregulation may occur or how it may be selected against in tumors as a mechanism of immune escape. Here, we report that the metastasis-associated microRNA (metastamir) miR-10b directly binds to the 3' untranslated region of MICB and downregulates its expression. Notably, antagonizing miR-10b action enhanced NKG2D-mediated killing of tumor cells in vitro and enhanced clearance of tumors in vivo. Conversely, overexpression of miR-10b downregulated MICB and impaired elimination of tumor cells. Together, our results define MICB as a novel immune target of miR-10b, implying a direct link between metastasis capability and immune escape from NK cells.
Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration
Authors: Seongho Ryu, Kevin McDonnell, Hyejin Choi, Dingcheng Gao, Mary Hahn, Natasha Joshi, Sun-Mi Park, Raul Catena, Yoonkyung Do, Jacqueline Brazin, Linda T. Vahdat, Randi B. Silver, Vivek Mittal
Journal: Cancer Cell (2013)
HER2 protein expression predicts response to trastuzumab in FISH-positive patients.
Authors: A Lipton, SM Ali, K Leitzel, W Koestler, E Fuchs, J Weidler, E Wu, J Sperinde, C Chappey, W Huang, M Bates
Journal: Cancer Research (2009)

Abstract Abstract #32 BACKGROUND: Fluorescent in Situ Hybridization (FISH) is currently employed to select patients for trastuzumab or lapatinib therapy. However, only a portion of patients will respond to these HER2-directed therapies. Using a novel assay to quantitate total HER2 (H2T) and HER2 homodimer (H2D) levels, we examined the relationship between these measurements and clinical outcomes in a cohort of trastuzumab-treated metastatic breast cancer patients previously assessed as FISH positive by central testing.&amp;#x2028; METHODS: The VeraTag assay was used to measure H2T and H2D. A cutoff previously defined by positional scanning was used to classify patients as H2T high or low (Leitzel et al. ASCO abstract # 1002, 2008). FISH status was determined using the Vysis assay and was performed by a single pathologist under standardized conditions (central testing). FISH + was defined as HER2/CEP17 ratio greater than 2.2. Kaplan-Meier and Cox proportional hazards analyses (TTP and OS) were conducted.&amp;#x2028; RESULTS: 99 MBC patients previously scored as IHC 3+ or 2+, FISH+ and treated with first line trastuzumab-containing regimens were re-tested by central FISH. 22 patients were found to be FISH- and 77 were FISH+. 67 FISH+ patients had high H2T levels, and 19 FISH- patients were H2T low. 14% (3/22) of FISH- patients were H2T high, and 13% (10/77) of FISH+ patients were H2T low (overall discordance rate = 13%). In Kaplan Meier analyses, patients assessed as FISH+, H2T high had a significantly longer TTP (median TTP=11.3 mos.) compared to those who were FISH-, H2T low (median TTP=4.5 mos. HR=0.42, p=0.0006), and also compared to those who were FISH+, H2T low (median TTP=3.7 mos. HR=0.43, p=0.01). Those patients who had discordant results (FISH+, but H2T low) behaved similarly compared with FISH-, H2T low (HR=1, p=0.99). Similar results were observed using H2D. In analyses restricted to central FISH+ patients only (N=77), Cox proportional hazards multivariate regression identified H2T as an independent predictor of TTP (HR=0.29, p=0.0015) and OS (HR=0.37, p=0.02).&amp;#x2028; CONCLUSION: In metastatic breast cancer patients previously assessed as FISH-positive by central testing, we observed an approximate 55-fold distribution of HER2 protein expression. Patients with HER2 gene amplification by FISH but low HER2 total protein expression or homodimer levels as measured by the VeraTag assay respond poorly to trastuzumab-containing therapy. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 32.
1032 DISSECTING THE ROLE OF Chk2, p53 AND p21 FOR LIVER REGENERATION AND TUMOR DEVELOPMENT DURING CHRONIC LIVER INJURY
Authors: L. Buitrago-Molina, S. Marhenke, J. Orlik, T. Longerich, R. Geffers, M. Manns, A. Vogel
Journal: Journal of Hepatology (2013)
EARLY CHANGES AT THE EPIPHYSIS OF RACHITIC CHICKS, FOLLOWING ADMINISTRATION OF VITAMIN D
Authors: Leonard F. Bélanger, B. B. Migicovsky
Journal: The Journal of Experimental Medicine (1958)

One day old chicks were fed a vitamin D-deficient diet for 3 weeks. Some were then given an oral dose of vitamin D and sacrificed at various times thereafter. The tibiae were x-rayed; demineralized sections were stained for neutral polysaccharides and sulfated mucopolysaccharides; other specimens were ashed; and others still were autoradiographed to determine their uptake of Ca(45)in vitro. Mineralization reappeared in the treated animals after 2 days, along with new P.A.S.-positive spicules. Earlier, the immature cartilage rapidly matured morphologically. At the same time, the rachitic matrix, highly concentrated in cation binder, presumably chondroitin sulfate, lost this material progressively.
The Medical-Book Business
Authors: Francis D. Moore
Journal: New England Journal of Medicine (1981)

Like so much else in medicine, the medical-book business is not only large but growing. The American Association of Publishers (AAP) reports that in 1969 1500 new medical books were published; by 1979 this figure had grown to 3200, and by 1980, to 3500. Included are works on medicine, nursing, and allied health professions as well as public policy in medicine and some bioscience (biology and biochemistry). The list excludes reprintings but does include new editions.In 1980 the Journal received 1997 books and reviewed 366. The last time this matter was analyzed (1970), the Journal was fourth among general . . .
Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26
Authors: Holger K. Eltzschig, Marion Faigle, Simone Knapp, Jorn Karhausen, Juan Ibla, Peter Rosenberger, Kirsten C. Odegard, Peter C. Laussen, Linda F. Thompson, Sean P. Colgan
Journal: Blood (2006)
A NOTE ON THE MORPHOLOGY OF A STRAIN OF TRYPANOSOMA EQUIPERDUM
Authors: W. Yorke, B. Blacklock
Journal: BMJ (1912)

NEARLY a year, ago, in examining stained films of our strains of trypanosomes, one of us observed in the blood Qf a guinea-pig short, stumpy forms-of parasite which had the macronucleus displaced towards the posterior end.The guinea-pig was infected with a laboratory strain of dourine, which-had been.received from Geheimrath Professor Uhlenhuth in Berlin in 1907.Recently in connexion with some work on "attachment " we had occasion to obtain a fresh supply of dourine virus, and we are indebted to Professor Schilling for his kindness-in sending us a rat infected with T. equiperdum and for giving its origin.This strain was obtained by
HORSE SHOE CLUB
Authors: C. S. Nicol
Journal: JAMA (1952)

To the Editor:—  It may interest any prospective medical visitors to Great Britain to know of the Horse Shoe Club. This club, which was founded in 1932, has the object of fostering Anglo-American relations in the medical field. It is particularly interested in aiding medical exchanges and in helping any visiting American to contact those who work in his own specialty. It also has certain funds that are devoted to providing entertainment for these visitors during their stay in Great Britain.  Inquiries should be addressed to the Honorary Secretary, Dr. C. S. Nicol, St. Bartholomew's Hospital, London, E.C.1, England.
Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias
Authors: Deborah L. Hodge, Jun Yang, Matthew D. Buschman, Paul M. Schaughency, Hong Dang, William Bere, Yili Yang, Ram Savan, Jeff J. Subleski, Xiao-Ming Yin, Thomas P. Loughran, Howard A. Young
Journal: Cancer Research (2009)

Large granular lymphocyte (LGL) leukemia is a clonal proliferative disease of T and natural killer (NK) cells. Interleukin (IL)-15 is important for the development and progression of LGL leukemia and is a survival factor for normal NK and T memory cells. IL-15 alters expression of Bcl-2 family members, Bcl-2, Bcl-XL, Bim, Noxa, and Mcl-1; however, effects on Bid have not been shown. Using an adoptive transfer model, we show that NK cells from Bid-deficient mice survive longer than cells from wild-type control mice when transferred into IL-15-null mice. In normal human NK cells, IL-15 significantly reduces Bid accumulation. Decreases in Bid are not due to alterations in RNA accumulation but result from increased proteasomal degradation. IL-15 up-regulates the E3 ligase HDM2 and we find that HDM2 directly interacts with Bid. HDM2 suppression by short hairpin RNA increases Bid accumulation lending further support for HDM2 involvement in Bid degradation. In primary leukemic LGLs, Bid levels are low but are reversed with bortezomib treatment with subsequent increases in LGL apoptosis. Overall, these data provide a novel molecular mechanism for IL-15 control of Bid that potentially links this cytokine to leukemogenesis through targeted proteasome degradation of Bid and offers the possibility that proteasome inhibitors may aid in the treatment of LGL leukemia.
CUTANEOUS AFFECTIONS OF CHILDHOOD
Authors: ALFRED SCHALEK
Journal: JAMA (1913)

The cutaneous affections of childhood, while only a part of the whole field of dermatology, and while of the same pathologic character as in adults, are still sufficiently different in their etiology, symptomatology and therapeutics to deserve a more individual consideration than they are given. Whatever notice is taken of them now in the dermatologic text-books is limited and widely scattered and for their connected study the reader might almost find more information in the treatises on pediatrics. The subject is too large to be covered thoroughly and systematically in a short paper. For this reason only a few points appertaining directly to cutaneous affections of childhood will be taken up in a general way and promiscuously. Skin diseases, especially of the acute type, occur proportionately more frequently in children than in adults. The reason for this is not far to seek. Local and general conditions combine to reduce the
Human Tumor Immunity
Authors: Richard T. Smith, William H. Adler
Journal: New England Journal of Medicine (1970)

During the past decade this country has made an enormous research investment in fundamental tumor immunobiology, and this has led to experimental delineation of important host-tumor inter-relations. Some of these basic observations give strong indications of a coming harvest of technics and concepts that will assist in the clinical management of human cancer patients. Three recent developments may herald such applications.The cellular immune response has been established as having a major role in the recognition and destruction of experimentally induced tumors. A more general, but as yet unproved, concept is that cellular surveillance is a major function of the . . .
Percutaneous Placement of an Intra-Aortic Balloon Pump in the Left Axillary/Subclavian Position Provides Safe, Ambulatory Long-Term Support as Bridge to Heart Transplantation
Authors: Jerry D. Estep, Andrea M. Cordero-Reyes, Arvind Bhimaraj, Barry Trachtenberg, Nashwa Khalil, Matthias Loebe, Brian Bruckner, Carlos M. Orrego, Jean Bismuth, Neal S. Kleiman, Guillermo Torre-Amione
Journal: JACC Heart Failure (2013)
Differences in location and electrophyslologic properties of atrial tachycardias in structurally normal and abnormal hearts
Authors: R.J. Verdino, M.C. Burke, D.E. Kopp, J.G. Kall, P.A. Cooke, C.T. Johnson, A.C. Lin, D.J. Wilber
Journal: Journal of the American College of Cardiology (1998)
Failed elective percutaneous transluminal coronary angioplasty requiring coronary artery bypass surgery. In-hospital and late clinical outcome at 5 years.
Authors: J D Talley, W S Weintraub, G S Roubin, J S Douglas, H V Anderson, E L Jones, D C Morris, H A Liberman, J M Craver, R A Guyton
Journal: Circulation (1990)

This study was performed to define the in-hospital and late clinical outcome at 5 years in 430 patients who had a failed elective percutaneous transluminal coronary angioplasty (PTCA) and underwent coronary artery bypass graft (CABG) surgery during their hospitalization. This group comprised 5.9% of 7,246 patients undergoing elective PTCA. CABG surgery was performed in 346 patients with ongoing myocardial ischemia (80.5%) and in 84 patients without ischemia (19.5%). Their mean age was 56 +/- 9 years, and 76.3% were male. One-vessel disease was present in 72.3%, and the mean left ventricular ejection fraction was 59 +/- 11%. Overall, 1.9 +/- 0.9 bypass grafts were placed. There was increased use of the internal thoracic artery in the nonischemic group. A new nonfatal postprocedural Q wave myocardial infarction occurred in 21.2% and occurred more frequently in the ischemic (25.4%) than in the nonischemic (3.6%) group (p less than 0.0001). There were six in-hospital deaths (1.4%), an incidence that did not differ between the two groups. Follow-up was 99.8% complete. There were 25 deaths (93.2 +/- 1.5%, 5-year survival), including 16 of cardiac cause (95.3 +/- 1.3%, 5-year cardiac survival). Q wave myocardial infarction occurred in 111 patients (91 in-hospital), and freedom from cardiac death or nonfatal myocardial infarction at 5 years was 71 +/- 3%. In the group going to CABG surgery with ongoing ischemia, the 5-year cardiac survival was 94.9 +/- 1.6%, and in the group without ischemia, the corresponding survival was 96.2 +/- 2.2%. By multivariate analysis, the presence of preoperative myocardial ischemia, pre-PTCA diameter stenosis less than 90%, and the presence of multiple-vessel disease correlated with the occurrence of cardiac death or nonfatal myocardial infarction at 5 years. At this large-volume center with extensive PTCA operator and surgical experience, the excellent survival and low event rates over 5 years support the concept that despite the failed elective PTCA procedure, there was little effect on long-term survival provided the patient underwent prompt successful surgical revascularization.
Response to Open Peer Commentaries on “An Open Letter to Institutional Review Boards Considering Northfield Laboratories' PolyHeme®<i>Trial</i>”:<i>The Emergency Exception and Unproven/Unsatisfactory Treatment</i>
Authors: Ken Kipnis, Nancy M. P. King, Robert M. Nelson
Journal: The American Journal of Bioethics (2006)

"Response to Open Peer Commentaries on “An Open Letter to Institutional Review Boards Considering Northfield Laboratories' PolyHeme® Trial”: The Emergency Exception and Unproven/Unsatisfactory Treatment ." The American Journal of Bioethics, 6(3), pp. W49–W50
The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3.
Authors: E C Lattime, G A Pecoraro, O Stutman
Journal: The Journal of Experimental Medicine (1983)

Murine natural killer (NK) and natural cytotoxic (NC) cells showed different patterns of augmentation of lytic activity after preincubation for 24 h with either poly-IC, interleukin 2 (IL-2), or interleukin 3 (IL-3): (a) Poly-IC augmented only NK cells, with no effect on NC activity, as we have previously observed (4); (b) IL-2 augmented both NK and NC activity; and (c) IL-3 augmented only NC lysis, without affecting NK activity. In addition, both precursor and the augmented effector cells showed differences in expression of the Qa-5 surface marker: NK precursors and effectors are Qa 5+, whereas NC precursors and effector cells are Qa-5-.
Thiabendazole Makes Happy Hogs
Authors: Ashton C. Cuckler
Journal: JAMA (1965)

To the Editor:—  It is possible that the happy hog inThe Journal'scover picture of Sept 13 owes his smile to the curing of his trichinellosis.  The photomicrographs actually illustrate the contrast between a Trichinella larva in a nontreated pig (top) and larvae in a pig treated with thiabendazole (bottom). It is true that larvae occasionally die in the striated muscle of untreated animals early in the course of the infection, and evoke a cellular response somewhat similar to that seen in two of the photographs. Most larvae, however, die only after many months of encapsulation, and the histological appearance of their capsules is quite different from that shown.
Abstract IA17: Stem cells and prostate cancer
Authors: Owen N. Witte
Journal: Cancer Research (2012)

Abstract Prostate cancer initiation and progression is associated with a myriad of genetic and epigenetic changes that drives the transformation process in specific cells of origin. Our group has developed a dissociated cell tissue regeneration system in which rodent or human epithelial tissue can be combined with supportive mesenchyme from the urogenital sinus to produce a tissue structure with glandular development. Introduction of specific oncogenic influences can drive normal tissue structure to a malignant histology with invasion and epithelial to mesenchymal transition. An efficient cell of origin from the basal layer of the gland has been defined for mouse and human tissue for this process and can produce malignant glands with luminal characteristics as well as other cellular phenotypes. Recent work has defined a set of changes in the adjacent stroma that can strongly influence the epithelium in its conversion to a cancerous state. Citation Format: Owen N. Witte. Stem cells and prostate cancer [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr IA17.