tbuckley/cabot-search huggingface dataset:
The Diagnostic Coding of Myocardial Infarction
Authors: Gordon D. Schiff
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 February 1989The Diagnostic Coding of Myocardial InfarctionGordon D. Schiff, MD, Adel S. Yaacoub, MDGordon D. Schiff, MD, Adel S. Yaacoub, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-3-243_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We are writing to confirm the findings of Iezzoni and colleagues (1). We reviewed 387 cases of patients discharged for acute myocardial infarction at a public general hospital from November 1985 to March 1988 that were coded according to the International Classification of Diseases, Clinically Modified, Ninth Revision (ICD-9-CM) (2). We found that 219 (57%) patients did not have an acute myocardial infarction during that period of hospitalization.We found, as did Iezzoni and colleagues, that the commonest cause of these 219 coding errors was the miscoding of a "ruled-out" myocardial infarction as an acute myocardial infarction...References1. Iezzoni L, Burnside S, Sickles L, Moskowitz M, Sawitz E, and Levine P. Coding of acute myocardial infarction: clinical and policy implications. Ann Intern Med. 1988;109:745-51. LinkGoogle Scholar2. International Classification of Diseases, Ninth Revision, Clinical Modification. Washington, D.C.: U. S. Government Printing Office; 1980; Publication no (PHS) 80-1260:366-7. Google Scholar3. Coding Clinic for ICD-9-CM. 1985; (March-April):3. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Gordon D. Schiff, MD; Adel S. Yaacoub, MDAffiliations: Cook County Hospital Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisagreement between Formal and Medical Record Criteria for the Diagnosis of Acute Coronary SyndromeA multicenter study of the coding accuracy of hospital discharge administrative data for patients admitted to cardiac care units in OntarioCoronary heart disease surveillanceAccuracy of administrative data in traumaCan Hospital Discharge Diagnosis be used for Surveillance of Bacteremia? A Data Quality Study of a Danish Hospital Discharge RegistryAnálisis automatizado de la calidad del conjunto mínimo de datos básicos. Implicaciones para los sistemas de ajuste de riesgosAcute Physiology and Chronic Health Evaluation II scoring system in acute myocardial infarctionA Measure of Mortality Risk for Elderly Patients with Acute Myocardial InfarctionUsing Administrative Diagnostic Data to Assess the Quality of Hospital Care: Pitfalls and Potential of ICD-9-CMMeasuring Health Care Effectiveness 1 February 1989Volume 110, Issue 3 Page: 243-243 Keywords Acute myocardial infarction Hospitalizations International Classification of Diseases International classification of diseases ninth revision clinical modification Myocardial infarction ePublished: 1 December 2008 Issue Published: 1 February 1989 PDF downloadLoading ...
Surgical management of staphylococcal pericarditis.
Authors: E W Cameron
Journal: Thorax (1975)

The surgical management of 10 patients with staphylococcal pericarditis is described. Of the 10, seven were children aged 12 years or under. A variety of procedures was used to drain the pericardium at open operation; these included left anterior thoracotomy, left anterolateral thoracotomy, median sternotomy, and the transdiaphragmatic approach to the pericardium. The pathological findings at operation are described. Two patients died; one of the deaths was related to the operation, the other was not. The remained eight patients were ultimately well although two required reoperation before recovery was achieved. After the initial diagnosis of pyopericardium, early consideration of operative drainage is advocated. An effective means of surgical management is dependent, open drainage of the pericardium approach by the transdiaphragmatic route.
HSV-1 Virions Engineered for Specific Binding to Cell Surface Receptors
Authors: Paola Grandi, Samuel Wang, Deborah Schuback, Victor Krasnykh, Matthew Spear, David T Curiel, Roberto Manservigi, Xandra O Breakefield
Journal: Molecular Therapy (2004)

Expression of specific peptide epitopes on the surface of virions has significant potential for studying viral biology and designing vectors for targeted gene therapy. In this study, an HSV-1 amplicon plasmid expressing a modified glycoprotein C (gC), in which the heparan sulfate binding domain was replaced with a His-tag, was used in generating HSV-1 virions. Western blot analysis demonstrated the presence of modified gC in the purified virions. The amplicon vectors were packaged using a gC−, lacZ+ helper virus to generate a mixture of high-titer helper virus (lacZ+) and amplicon vectors (GFP+), which expressed modified gC in the virion envelope. His-tagged virions bound to 293 6H cells expressing a cell surface pseudo-His-tag receptor four-fold more efficiently than to parental 293 cells and also proved more effective than wild-type virus in binding to both cell types. Binding resulted in productive infection by the modified virions with expression of reporter genes and cytopathic effect comparable to those of wild-type virions. Thus, not only can HSV-1 tropism be manipulated to recognize a non-herpes simplex binding receptor, but it is also possible to increase the infective capacity of the vectors beyond that of the wild-type virus via specific ligand receptor combinations.
Eli Lilly defends itself against assertions in <i>BMJ</i>
Authors: Jeanne Lenzer
Journal: BMJ (2005)

In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 µg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with natural boosting from residual diseases and colonisation. Generally, serotype-specific IgG could persist above 0.35 µg/mL longer (≥5 years) in the catch-up group than in the 2+1 and 3+1 immunisation groups. 14.5% of the carriage isolates belonged to PCV13 serotypes; statistical analysis revealed that a high serum IgG level (&gt;10.96 µg/mL) will be required to eliminate the point-prevalence nasopharyngeal carriage of serotype 19A.
Medical Care of Cambodian Refugees
Authors: J. L. Conrad
Journal: JAMA (1981)

To the Editor.—  Although we agree with most of the comments of Keith Dahlberg, MD (1980;243:1062), on the Cambodian refugees and their treatment for malnutrition and other medical conditions, his recommendations on personal care for refugee workers are subject to further comments.  For newly arriving refugee workers from nontropical environments who are not acclimatized to the heat, adequate hydration is a must. However, the use of salt tablets should not be encouraged; rather, supplemental table salt taken with meals along with sufficient fluids is recommended. 1 Salt tablets are often taken needlessly, irregularly, and not always with adequate fluids; their rate of disintegration in the gastrointestinal tract is unpredictable. Western diets frequently include too much salt; therefore, continuing to use the same amount of salt as we use at home will probably suffice for most people while working in the tropics.
Desmin-regulated Lentiviral Vectors for Skeletal Muscle Gene Transfer
Authors: Gillian E Talbot, Simon N Waddington, Olivia Bales, Rose C Tchen, Michael N Antoniou
Journal: Molecular Therapy (2009)

Lentiviral vectors (LVs) are highly attractive as a gene therapy agent as they are able to stably integrate their genomes in both dividing and nondividing cells and, in principle, provide long-term therapeutic benefit. However, their performance in skeletal muscle in adult animals has, to date, been disappointing. In order to gain clearer insight into their utility in this tissue type, we have conducted an extensive quantitative comparison of constitutive and muscle-specific promoter activities in skeletal muscle and nonmuscle systems following LV delivery in cell lines and neonatal mice. Our data show that LV delivery to hind leg skeletal muscle of neonatal mouse results in long-term transgene expression in adulthood. We find that the human desmin (DES) promoter/enhancer is the first muscle-specific control region to match the activity of the highly active constitutive human cytomegalovirus (hCMV) promoter/enhancer in skeletal muscle within a LV context both in vitro and in vivo. Furthermore, the DES promoter/enhancer provides six- to eightfold greater expression per viral copy than the muscle-specific human muscle creatine kinase (CKM) promoter/enhancer. DES also confers a more reproducible and tissue-specific transgene expression profile compared to CKM and is therefore a highly attractive regulatory element for use in muscle gene therapy vectors. Lentiviral vectors (LVs) are highly attractive as a gene therapy agent as they are able to stably integrate their genomes in both dividing and nondividing cells and, in principle, provide long-term therapeutic benefit. However, their performance in skeletal muscle in adult animals has, to date, been disappointing. In order to gain clearer insight into their utility in this tissue type, we have conducted an extensive quantitative comparison of constitutive and muscle-specific promoter activities in skeletal muscle and nonmuscle systems following LV delivery in cell lines and neonatal mice. Our data show that LV delivery to hind leg skeletal muscle of neonatal mouse results in long-term transgene expression in adulthood. We find that the human desmin (DES) promoter/enhancer is the first muscle-specific control region to match the activity of the highly active constitutive human cytomegalovirus (hCMV) promoter/enhancer in skeletal muscle within a LV context both in vitro and in vivo. Furthermore, the DES promoter/enhancer provides six- to eightfold greater expression per viral copy than the muscle-specific human muscle creatine kinase (CKM) promoter/enhancer. DES also confers a more reproducible and tissue-specific transgene expression profile compared to CKM and is therefore a highly attractive regulatory element for use in muscle gene therapy vectors.
Epidemiology and outcome of invasive pneumococcal disease among adults in Belgium, 2009–2011
Authors: J Verhaegen, J Flamaing, W De Backer, B Delaere, K Van Herck, F Surmont, Y Van Laethem, P Van Damme, W Peetermans
Journal: Eurosurveillance (2014)

This epidemiological study examined morbidity and case fatality of invasive pneumococcal disease (IPD) in adults in Belgium as well as distribution and antibiotic susceptibility of Streptococcus pneumoniae serotypes. Adults hospitalised with microbiologically proven IPD were prospectively enrolled. The study started in 2009 with patients aged ≥50 years, whereas in 2010 and 2011, patients aged ≥18 years were included. The clinical presentation, patient profile, treatment, outcome, and mortality were recorded during hospitalisation. Outcome was also assessed one month after discharge. Of the 1,875 patients with IPD identified, 1,332 were included in the analysis. Bacteraemic pneumonia, affecting 1,049 of the patients, was the most frequent IPD type (79%), and chronic obstructive pulmonary disease and cancer were the main comorbidities. One-third of patients required admission to intensive care unit. A total of 208 (16%) patients died during hospitalisation and an additional 21 (2%) within one month after discharge. Case fatality rates of ≥20% were observed in patients with chronic heart failure, hepatic disease, and renal insufficiency. Serotypes 7F, 1, 19A, and 3 were the most prevalent and together accounted for 47% (569/1,214) of all IPD cases and 42% (80/189) of mortality. Of the patient isolates, 21% (255/1,204) were resistant to erythromycin and 22% (264/1,204) to tetracycline. Penicillin non-susceptibility was mostly found in serotype 19A isolates. These baseline data are essential when assessing the impact of pneumococcal conjugate vaccination in adults in the future.
Standardizing Fecal Occult Blood Testing
Authors: Siva Maran, Thomas P. Short, Eapen Thomas
Journal: Annals of Internal Medicine (1991)

Letters1 October 1991Standardizing Fecal Occult Blood TestingSiva Maran, MD, Thomas P. Short, MD, Eapen Thomas, MDSiva Maran, MDSearch for more papers by this author, Thomas P. Short, MDSearch for more papers by this author, Eapen Thomas, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-7-576_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:In their recent article, Fleisher and colleagues (1) stressed the need to pay careful attention to visual interpretation of the fecal occult blood test using Hemoccult II slides (SmithKline Diagnostics, Inc., San Jose, California). We request clarification of the following points: What were the volumes of blood and stool used to yield "moderately positive" and "strongly positive" results? What were the specific "instructions" given to the evaluators who were asked to read the samples? Were evaluators shown color pictures of "negative," "moderately positive," and "strongly positive" specimens? We feel it would be beneficial to have these data...Reference1. FleisherWinawerZauberSmithSchwartz MSACM. Accuracy of fecal occult blood test interpretation. Ann Intern Med. 1991;114:875-6. LinkGoogle Scholar1. FleisherWinawerZauberSmithSchwartz MSACM. Accuracy of fecal occult blood test interpretation. Ann Intern Med. 1991;114:875-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: James H. Quillen College of Medicine Johnson City, TN 37601 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1991Volume 115, Issue 7Page: 576-577KeywordsBlood volumeDiagnostic techniquesHematologic tests Issue Published: 1 October 1991 PDF downloadLoading ...
Beneficial effect of physical training on blood flow to myocardium perfused by chronic collaterals in the exercising dog.
Authors: W H Heaton, K C Marr, N L Capurro, R E Goldstein, S E Epstein
Journal: Circulation (1978)

To determine the effect of physical training on collateral blood flow, we measured regional myocardial blood flow (MBF) by injecting 15 mu radioactive microspheres at rest and during exercise in 14 dogs with chronic coronary occlusive lesions. Seven dogs subsequently trained for 6 weeks while the other seven remained in kennels. Training effect was documented by decrease in heart rate during exercise that averaged 35 beats/min. MBF studies were repeated after 6 weeks. Myocardial samples were obtained from normally perfused zones (NZ) and from regions supplied via collaterals (collateral dependent zones or CZ). Initially, endocardial blood flow in CZ averaged 1.110 ml/min/g (83% of NZ, P less than 0.05) at rest and 1.36 ml/min/g (69% of NZ, P less than 0.05) during exercise, indicating relative underperfusion. Epicardial blood flow was equal in NZ and CZ. After 6 weeks MBF was not significantly changed in control animals. After training, however, MBF to underperfused endocardium of CZ during exercise was 39% greater than it had been prior to training. The epicardial portion of CZ (not exhibiting underperfusion) showed no change in MBF during exercise after training. Our data suggest that beneficial effects of training in coronary disease may include improvement in MBF to underperfused collateral-dependent portions of myocardium.
Medical Care and Health Insurance; a Study in Social Progress.
Authors: W. F. Norwood
Journal: JAMA (1963)

Economic pressure, the passion for security, the crucial importance of health to the individual and the nation, and a worshipful acclaim of advances in the health sciences have forced medical care and health insurance to the foreground. Scarcely a man on the street will decline to express some opinion on this subject. In response to the need for reliable information, Mr. J. F. Follmann, Jr., Director of Information and Research, Health Insurance Association of America, has written this factual volume which carries the subtitle, "A study in social progress." Mr. Follmann does not deny having a viewpoint, but he is, in this reviewer's opinion, remarkably free of the bias and obscurantism which characterize some declarations on both sides in this great American dialogue. Content and treatment of the subject truly justify the jacket statement: "This significant book provides a thorough analysis of the methods of financing medical care in both
Serum Urea Concentrations
Authors: Clarence Cohn
Journal: JAMA (1966)

From a historical viewpoint, urea is the first organic compound to have been synthesized by man in vitro; physiologically, by contrast, urea is the "last" one to be formed by him in vivo after a protein meal. Thus in the mammal, urea is the chief end product of protein metabolism, comprising some 80% of the non-protein nitrogen normally excreted in the urine per 24 hours.<sup>1</sup> Urea is generated in the liver as the end product of the activity of the first enzymatic cycle to have been described by Krebs, the ornithine-arginine-urea cycle.<sup>2</sup>Amino acids, derived from dietary protein or from peripheral tissues, consequent to the interchange of serum (dietary) and tissue amino acids, serve as the precursors fed into the enzymatic "degradation" process. The rate of urea formation is determined by the quantity of amino acids presented to the liver per unit of time. Accordingly, urea synthesis is
The Treatment of Puerperal Eclampsia by Diuretic Infusions, with a Table of Twenty-Two Cases
Authors: R. Jardine
Journal: BMJ (1900)

CASES of absence of fusion of the Millerian ducts to a greater or less extent are of comparative frequency, and as might be expected give rise to almost endless varieties of anomalous conditions.These are of great interest, not only on account of their anatomical peculiarities but more particularly from a clinical standpoint, as the pathological effects of arrested development tend frequently to extremely grave conse- quences, and at the same time are often surrounded with
Benefits of reperfusion beyond infarct size limitation
Authors: G. Takemura, M. Nakagawa, H. Kanamori, S. Minatoguchi, H. Fujiwara
Journal: Cardiovascular Research (2009)

The most critical determinant of prognosis in patients with acute myocardial infarction (MI) is infarct magnitude, which can be established within several hours of an attack. The importance of the subsequent healing process is not negligible, however. In fact, much experimental and clinical evidence suggests that late reperfusion of the infarct-related coronary artery--i.e. at times too late to salvage the myocardium within the area at risk-is beneficial for reducing left ventricular remodelling and decreasing mortality ('open artery hypothesis'). For instance, one recent study highlighted the beneficial effects of late reperfusion therapy on the infarct tissue cell dynamics following acute MI. Nonetheless, several recent large, randomized clinical trials have failed to provide evidence of such benefits, refuting the clinical efficacy of late reperfusion. In addition, they also underscore the need for revised clinical studies in which there is less heterogeneity in the timing of reperfusion and in the initial infarct size, as well as the need for sustained patency of the recanalized artery. This review focuses on the effects of late reperfusion on the pathophysiology of MI in the context of the infarct tissue dynamics and clinical outcomes. We also discuss the issues that need to be resolved to improve clinical application.
Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis
Authors: Piergiovanni Buonamici, Rossella Marcucci, Angela Migliorini, Gian Franco Gensini, Alberto Santini, Rita Paniccia, Guia Moschi, Anna Maria Gori, Rosanna Abbate, David Antoniucci
Journal: Journal of the American College of Cardiology (2007)
Anatomic correction of simple transposition of the great arteries in 50 neonates.
Authors: D Sidi, C Planché, J Kachaner, J Bruniaux, E Villain, J le Bidois, J F Piéchaud, F Lacour-Gayet
Journal: Circulation (1987)

From April 1984 to January 1986, anatomic surgical correction was performed in 50 newborn (2- to 23-day-old, mean 8 +/- 5 [SD]) infants with simple transposition of the great arteries. Before surgery, balloon atrial septostomy was performed in all patients, prostaglandin E1 was infused in 42, and left ventricular shape on a two-dimensional echocardiogram was considered "satisfactory" in 48. Surgery was performed in patients on cardiopulmonary bypass without cardiac arrest; the pulmonary artery was reconstructed by end-to-end anastomosis according to Lecompte's maneuver with a pericardial patch. In all but one patient coronary artery transfer was possible regardless of the distribution of these vessels. There were eight early deaths (16%), but only four (10%) of the last 41 patients treated died. There was one late death (2%) due to a secondary myocardial infarction caused by compression of the left coronary artery. Reoperation was successfully performed in two patients for supravalvar pulmonary artery stenosis. The only late medical complication was a transient episode of myocardial ischemia 6 months after surgery. The 41 late survivors were in excellent condition, were in sinus rhythm, and had a normal left ventricle 1 to 22 months after surgery (mean 7.2 +/- 5.4 [SD]). Aortic growth was normal; pulmonary artery supravalvar stenosis occurred in six patients (mild in four). We conclude that anatomic correction can be applied successfully in the first few days of life in newborns with simple transposition of the great arteries, regardless of coronary distribution.
Risk Stratification in Cancer Predisposition Syndromes: Lessons Learned from Novel Molecular Developments in Li-Fraumeni Syndrome
Authors: Uri Tabori, David Malkin
Journal: Cancer Research (2008)

Abstract Germ-line mutations in specific genes predispose family members to cancer. Prediction of the exact tumor type and timing of cancer initiation is fundamental to the development of management strategies for these individuals. Recent advances in our understanding of the general processes that control cancer initiation may enable us to tailor more precise risk stratification. This, in turn, will lead to more effective early detection strategies, which would result in more favorable clinical outcomes. In this review, we highlight the steps and methods used to reach this futuristic model. [Cancer Res 2008;68(7):2053–7]
Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells
Authors: Sandra Düber, Martin Hafner, Martina Krey, Stefan Lienenklaus, Bishnudeo Roy, Elias Hobeika, Michael Reth, Thorsten Buch, Ari Waisman, Karsten Kretschmer, Siegfried Weiss
Journal: Blood (2009)
Primidone (Mysoline) in the Treatment of Epilepsy
Authors: Samuel Livingston, Don Petersen
Journal: New England Journal of Medicine (1956)

THE first report dealing with the use of primidone (Mysoline) in the treatment of epilepsy was presented in 1952 by Handley and Stewart.1 Many other investigators2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 subsequently used this drug for the control of epileptic seizures. In 1953 Doyle and Livingston8 analyzed the results obtained in 100 patients with epilepsy who had been given primidone for periods of three months to one year. The purpose of the present paper is to report our findings in a larger group of patients who received this drug for a much longer period.Material for StudyThe drug was administered to 486 patients who . . .