Familial Helicobacter pylori Infection: Societal Factors, Human Genetics, and Bacterial Genetics
Authors: Vincent M. Riccardi
Journal: Annals of Internal Medicine (1994)

Editorials15 June 1994Familial Helicobacter pylori Infection: Societal Factors, Human Genetics, and Bacterial GeneticsVincent M. Riccardi, MD, MBA and Jerome I. Rotter, MDVincent M. Riccardi, MD, MBAThe Neurofibromatosis Institute, La Crescenta, CA 91214. Cedars-Sinai Medical Center and the University of California at Los Angeles School of Medicine, Los Angeles, CA 90048.Search for more papers by this author and Jerome I. Rotter, MDThe Neurofibromatosis Institute, La Crescenta, CA 91214. Cedars-Sinai Medical Center and the University of California at Los Angeles School of Medicine, Los Angeles, CA 90048.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-12-199406150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Given the chance, a medical geneticist will remind you of two things: Almost all human disorders have a genetic element; and, even when a genetic element is paramount, one or more environmental elements contribute to shaping the disease process. Many common human disorders occur because of an interplay of genetic and environmental factors [1].Primary care clinicians should not say “so what.” The point is that different diagnostic and treatment strategies for common disorders may have to be tailored to each of the two causative elements, genetic and environmental. This dual approach is among the messages of a pair of ...References1. King RA, Rotter JI, Motulsky AG, eds. The Genetic Basis of Common Diseases. New York: Oxford University Press; 1992. Google Scholar2. Malaty HM, Engstrand L, Pedersen NL, Graham DY. Helicobacter pylori infection: genetic and environmental influences. A study of twins. Ann Intern Med. 1994; 120:982-6. Google Scholar3. Nomura A, Stemmermann GN, Chyou PH, Perez-Perez GI, Blaser MI. Helicobacter pylori infection and the risk for duodenal and gastric ulceration. Ann Intern Med. 1994; 120:977-81. Google Scholar4. Rotter JI, Shohat T, Petersen GM. Peptic ulcer disease. In: King RA, Rotter JI, Motulsky AG, eds. The Genetic Basis of Common Diseases. New York: Oxford University Press; 1992:240-78. Google Scholar5. Lam SK. Epidemiology and genetics of peptic ulcer. Gastroenterol Jpn. 1993; 28(Suppl 5):145-57. Google Scholar6. Rotter JI, Petersen G, Samloff IM, McConnell RB, Ellis A, Spence MA, et al. 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Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science. 1993; 262:1892-5. Google Scholar12. Hook-Nikanne J, Sistonen P, Kosunen TU. Effect of ABO blood group and secretor status on the frequency of Helicobacter pylori antibodies. Scand J Gastroenterol. 1990; 25:815-8. Google Scholar13. Yoshimura HH, Evans DG, Graham DY. DNA-DNA hybridization demonstrates apparent genetic differences between Helicobacter pylori from patients with duodenal ulcer and asymptomatic gastritis. Dig Dis Sci. 1993; 38:1128-31. Google Scholar14. Samloff IM, Stemmermann GN, Heilbrun LK, Nomura A. Elevated serum pepsinogen I and II levels differ as risk factors for duodenal and gastric ulcer. Gastroenterology. 1986; 90:570-6. Google Scholar15. Moss SF, Calam J. Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: Effect of eradication of Helicobacter pylori. Gut. 1993; 34:888-92. Google Scholar16. Dixon M. Acid, ulcers, and H. pylori. Lancet. 1993; 342:384-5. Google Scholar17. Stead WW. Genetics and resistance to tuberculosis. Could resistance be enhanced by genetic engineering? Ann Intern Med. 1992; 116:937-41. Google Scholar Author, Article, and Disclosure InformationAffiliations: The Neurofibromatosis Institute, La Crescenta, CA 91214. Cedars-Sinai Medical Center and the University of California at Los Angeles School of Medicine, Los Angeles, CA 90048.Corresponding Author: Vincent M. Riccardi,MD, MBA, The Neurofibromatosis Institute, 5415 Briggs Avenue, La Crescenta, CA 91214. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHelicobacter pylori Infection and the Risk for Duodenal and Gastric Ulceration Abraham Nomura , Grant N. Stemmermann , Po-Huang Chyou , Guillermo I. Perez-Perez , and Martin J. Blaser Helicobacter pylori Infection: Genetic and Environmental Influences: A Study of Twins Hoda M. Malaty , Lars Engstrand , Nancy L. Pedersen , and David Y. Graham Metrics Cited ByInfluence of Helicobacter pylori virulence factors CagA and VacA on pathogenesis of gastrointestinal disordersHelicobacter pylori and Gastroduodenal DisordersIntra-familial Transmission of Helicobacter pylori Infection in Children of Households with Multiple Generations in VietnamGastrointestinal ComplicationsHP0333, a Member of the dprA Family, Is Involved in Natural Transformation in Helicobacter pyloriHelicobacter pylori - a conundrum of genetic diversityEvidence for a Conjugation-Like Mechanism of DNA Transfer in Helicobacter pyloriHelicobacter pylori infection in spouses of patients with duodenal ulcers and comparison of ribosomal RNA gene patterns.Helicobacter pylori infection and peptic ulcer disease in children 15 June 1994Volume 120, Issue 12Page: 1043-1045KeywordsBacteriaBlood groupsGastric ulcersGastritisGenetic diseasesGenetic predispositionGeneticsHelicobacter pylori infectionPeptic ulcersTwins Issue Published: 15 June 1994 CopyrightCopyright © 1994 by American College of Physicians. 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