Trimethoprim-Sulfamethoxazole and Bacterial Infections During Leukemia Therapy
Authors: LOWELL S. YOUNG
Journal: Annals of Internal Medicine (1981)

Editorials1 October 1981Trimethoprim-Sulfamethoxazole and Bacterial Infections During Leukemia TherapyLOWELL S. YOUNG, M.D.LOWELL S. YOUNG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-4-508 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor physicians who treat leukemic patients the relative ease of giving cytotoxic chemotherapy is greatly over-shadowed by the challenge of managing the infections that often complicate the granulocytopenic state. Many approaches have been used to prevent bacterial infection in compromised hosts, but one of the first was prophylactic antibiotics. More than 20 years ago agents such as tetracycline were found to be neither efficacious in reducing fever and infection nor helpful in prolonging life (1). More recently, however, there has been renewed interest in antimicrobial prophylaxis as a cost-effective means of reducing infection in neutropenic patients, particularly because at least...References1. BOGGSFREIZIERDT DEC. Fever in malignant neoplastic disease: a controlled study of tetracycline therapy. Ann Intern Med. 1960;53:754-64. LinkGoogle Scholar2. SCHIMPFFGREENEYOUNG SWV. Infection prevention in acute nonlymphocytic leukemia: laminar air flow room reverse isolation with oral, nonabsorbable antibiotic prophylaxis. Ann Intern Med. 1975;82:351-8. LinkGoogle Scholar3. YOUNG L. Nosocomial infections in the immunocompromised adult. Am J Med. 1981;70:398-403. CrossrefMedlineGoogle Scholar4. SCHIMPFF S. Infection prevention during profound granulocytopenia: new approaches to alimentary canal microbial suppression. Ann Intern Med. 1980;93:358-61. LinkGoogle Scholar5. STORRINGJAMESONMCELWAINWILTSHAWSPIERSGAYA RBREAH. Oral non-absorbed antibiotics prevent infection in acute non-lymphoblastic leukaemia. Lancet. 1977;2:837-40. CrossrefMedlineGoogle Scholar6. HUGHESKUHNCHAUDHARY WSS. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med. 1977;297:1419-26. CrossrefMedlineGoogle Scholar7. GURWITHBRUNTONLANKHARDINGRONALD MJBGA. A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients. Am J Med 1979;66:248-56. CrossrefMedlineGoogle Scholar8. ENNOCATOVSKYDARRELLGOLDMANHOWSGALTON ADJJJD. Co-trimoxazole for prevention of infection in acute leukemia. Lancet. 1978;2:395-7. CrossrefMedlineGoogle Scholar9. WADESCHIMPFFHARGADONFORTNERYOUNGWIERNIK JSCCVP. A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia. N Engl J Med. 1981;304:1057-61. CrossrefMedlineGoogle Scholar10. WEISERLANGEFIALKSINGERSZATROWSKIARMSTRONG BMMCTD. Prophylactic trimethoprin-sulfamethoxazole during consolidation chemotherapy for acute leukemia: a controlled trial. Ann Intern Med. 1981;95:436-8. LinkGoogle Scholar11. . Double-blind placebo-controlled trial of prophylactic trimethoprim and sulfamethoxazole for the prevention of infection in granulocytopenic patients. In: MOELLERING RE, ed. 20th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, D.C.: American Society for Microbiology; 1980. Abstract No. 331. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Infectious Diseases Department of Medicine UCLA School of Medicine Center for the Health Sciences Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByManagement of Infections in Leukemia and LymphomaManagement of Infections in Leukemia and LymphomaPrevention of Infection by Gramnegative MicroorganismsAntimicrobial prophylaxis in the neutropenic host: Lessons of the past and perspectives for the futureManagement of Infections in Leukemia and LymphomaThe New Fluorinated Quinolones for Infection Prevention in Acute LeukemiaLOWELL S. YOUNG, M.D.Chemoprophylaxis of bacterial infections in granulocytopenic patientsColistin and trimethoprim-sulfamethoxazole for the prevention of infection in patients with acute non-lymphocytic leukaemia. Decrease in the emergence of resistant bacteriaWandel der Therapieergebnisse bei akuter Leuk�mie unter Anwendung verschiedener Behandlungsschemata, mit besonderer Ber�cksichtigung spezieller gnotobiotischer Ma�nahmenA Prospective Study of Infectious Diseases Following Bone Marrow Transplantation: Emergence of Aspergillus and Cytomegalovirus as the Major Causes of Mortality 1 October 1981Volume 95, Issue 4Page: 508-509KeywordsAntibioticsAntimicrobialsCytotoxic chemotherapyFeversProphylaxisTetracyclines Issue Published: 1 October 1981 PDF DownloadLoading ...