tbuckley/cabot-search huggingface dataset:
O166 ALL-ORAL DUAL THERAPY WITH DACLATASVIR AND ASUNAPREVIR IN PATIENTS WITH HCV GENOTYPE 1B INFECTION: PHASE 3 STUDY RESULTS
Authors: M. Manns, S. Pol, I. Jacobson, P. Marcellin, S. Gordon, C.-Y. Peng, T.-T. Chang, G. Everson, J. Heo, G. Gerken, B. Yoffe, W.J. Towner, M. Bourliere, S. Metivier, C.-J. Chu, W. Sievert, J.-P. Bronowicki, D. Thabut, Y.-J. Lee, J.-H. Kao, F. McPhee, J. Kopit, P. Mendez, M. Linaberry, E. Hughes, S. Noviello
Journal: Journal of Hepatology (2014)
A Comparison of Aorta and Vena Cava Medial Message Expression by cDNA Array Analysis Identifies a Set of 68 Consistently Differentially Expressed Genes, All in Aortic Media
Authors: Lawrence D. Adams, Randolph L. Geary, Bruce McManus, Stephen M. Schwartz
Journal: Circulation Research (2000)

We performed a systematic analysis of gene expression in arteries and veins by comparing message profiles of macaque aorta and vena cava media using a cDNA array containing 4048 known human genes, approximately 35% of currently named human genes (approximately 11,000). The data show extensive differences in RNA expression in artery versus vein media. Sixty-eight genes had consistent elevation in message expression by the aorta, but none were elevated in the vena cava. The most differentially expressed gene was regulator of G-protein signaling (RGS) 5, at an expression ratio of 46.5+/-12.6 (mean+/-SEM). The data set also contained 2 genes already known to be expressed in the aorta, elastin at 5.0+/-1.4, and the aortic preferentially expressed gene 1 (APEG-1) at 2.3+/-0.6. We chose to analyze RGS5 expression further because of its high level of differential expression in the aorta. Levels of RGS5 mRNA were confirmed by Northern analysis and in situ hybridization. A human tissue RNA dot blot showed that RGS5 message is highest in aorta, followed by small intestine, stomach, and then heart. Northern analysis confirmed that RGS5 expression in human aorta is higher than in any region of the heart. RGS5 is a G-protein signaling regulator of unknown specificity most homologous to RGS4, an inhibitory regulator of pressure-induced cardiac hypertrophy. The expression pattern of the 68 differential genes as a whole is a start toward identifying the molecular phenotypes of arteries and veins on a systematic basis.
STUDIES ON THE DISSOCIATION OF THE HOG CHOLERA BACILLUS
Authors: C. P. Li
Journal: The Journal of Experimental Medicine (1929)

1. Heat killed organisms of the MS (OH), MR (ØH), NS (O) or NR (Ø) forms of hog cholera bacilli failed to confer immunity, at least to any considerable degree, in hamsters or rabbits against virulent hog cholera bacilli. 2. Hamsters and rabbits were successfully immunized against virulent MS bacilli by vaccination with living MR (ØH) and NR (Ø) forms. 3. Hamsters were immunized against MS hog cholera bacilli with living R paratyphoid "C" bacilli and conversely against MS paratyphoid "C" bacilli with living R hog cholera bacilli.
Abstract B9: Activated MAPK Pathway Mediates Resistance to Romidepsin via Bim Degradation in Romidepsin-Selected HuT 78 Cells
Authors: Arup Chakraborty, Robert Robey, Jean-Pierre Gillet, Victoria Luchenko, Richard Piekarz, Michael Gottesman, Nathan Collie, Susan Bates
Journal: Clinical Cancer Research (2012)

Abstract Acquired and intrinsic resistance to histone deacetylase inhibitors (HDIs), a new targeted group of anti-tumor agents, limits their clinical efficacy. A detailed understanding of the mechanisms of resistance to HDIs may lead to strategies designed to increase clinical efficacy. To investigate molecular mechanisms of resistance to the HDI romidepsin (Dp), we studied a cutaneous T-cell lymphoma (CTCL) cell line, HuT 78, independently selected in verapamil (Vp) or valspodar (PSC833) to prevent the emergence of P-glycoprotein (Pgp), a known resistance mechanism. The HuT 78 sublines DpVp 50 and DpP 75 display 100-200-fold resistance to romidepsin, not due to Pgp expression. A custom-made Taqman low density gene expression array detected increased expression of insulin receptor (IR) in the resistant cells. Real-time PCR analysis confirmed the results of gene array and detected more than 50-fold upregulation of IR in the romidepsin-selected cells compared to the parental cells. Increased phosphorylation (5- to 8- fold) of mitogen activated protein kinase kinase (MEK), a downstream effector of the IR pathway, was also observed in the resistant cells compared to the parental cells. While HuT 78 cells were insensitive to MEK inhibition, resistant cells were found to be exquisitely sensitive to MEK inhibition (IC50 &amp;lt; 10 nM) but not to phosphatidylinositol 3-kinase (PI3K) inhibition. Combined treatment of romidepsin with low concentrations (1- 3 nM) of MEK inhibitor also resulted in increased cell death in romidepsin-resistant HuT 78 cells. The exquisite sensitivity to MEK inhibition in the resistant sublines was found to correlate with restoration of the expression of Bim (BCL2L11), a Bcl-2-homology domain-3 only (BH-3) proapoptotic protein. In the resistant cells, the MAPK pathway appeared to regulate Bim expression posttranslationally as we did not detect any gene induction of BCL2L11 or FOXO3, a transcription factor known to activate BCL2L11 expression, following MEK inhibition. These findings implicate increased activation of the MAPK pathway as a mechanism of resistance to romidepsin, and suggest that combining romidepsin with MEK inhibitors may be an effective strategy to overcome resistance.
'Scalded Sardine' Scurvy
Authors: Victor Herbert
Journal: JAMA (1981)

<h3>To the Editor.—</h3> It is often claimed that scurvy has disappeared from the United States. In fact, we frequently see it among patients with alcoholism when they first arrive at the emergency room. They have classic perifollicular hemorrhages surrounding corkscrew hairs. These look like a tiny circle of dirt, but spring up when the plug of keratin under which they have corkscrewed is flicked away with a penknife, scalpel, or needle point. Often the diagnosis is missed, and the scurvy is treated by the first glass of orange juice the patient receives or by the diet and the cessation of alcohol while in the hospital. Aware of this diagnosis, a member of our Bronx Veterans Administration Medical Center house staff recently asked me to see a patient whose thigh ecchymoses and perifollicular hemorrhages suggested scurvy, though he was not an alcoholic and said he "ate well." Flicking away several keratinized
Comprehensive health planning
Authors: M. O. Rouse
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRACTURE OF THE UPPER THIRD OF THE FEMUR SUCCESSFULLY TREATED WITH PLASTER OF PARIS WITHOUT EXTENSION.
Authors: L. SEXTON
Journal: JAMA (1903)

Fractures of the shaft of the femur are very common accidents, despite the strength of the bone. The lower end of the bone is more frequently broken than the upper. Fractures of the upper third are usually due to indirect violence, and of the lower third to direct injury. The course of the fracture is usually oblique. Marked angular, rotary and longitudinal displacements usually attend these fractures. The lower fragment is usually drawn to the inner side and behind the upper; this tendency to deformity is greatest when the fracture occurs in the upper third. Every kind and variety of fracture is liable to occur to the femur. On account of the large muscular attachments to the bone, displacements are nearly always present in fractures of the femur, and this is especially true in relation to fractures of the upper third, when the bone is tilted forward by the action
Fact or fiction about formaldehyde?
Authors: P. Gunby
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute pulmonary reaction to nitrofurantoin
Authors: R. F. Pinerua, B. J. S. Hartnett
Journal: Thorax (1974)

<b>Pinerua, R. F. and Hartnett, B. J. S. (1974).</b><i>Thorax</i>, <b>29,</b> 599-602. <b>Acute pulmonary reaction to nitrofurantoin.</b> Acute pulmonary reaction to nitrofurantoin is a rare complication of a commonly used drug. This report of such a reaction presents studies of pulmonary function more detailed than are so far available. Studies made nine days after the drug had been withdrawn showed arterial hypoxaemia and abnormalities in ventilation-perfusion relationships. Challenge with 200 mg nitrofurantoin produced increased minute ventilation, hypoxaemia, hypocapnia, deterioration in ventilation-perfusion relationships, marked veno-arterial shunting, and a fall in steady-state transfer factor for carbon monoxide and fractional carbon monoxide uptake. Spirometry and lung volume measurements indicated a restrictive lung abnormality without effect on large airways which persisted for at least nine weeks. Three years later there had been complete resolution of the process, apart from some persistent reduction in transfer factor, possibly related to the patient9s smoking habits.
An electron microscopic study of epithelium of normal human sigmoid colonic mucosa.
Authors: F E Pittman, J C Pittman
Journal: Gut (1966)

COMMENT This is a basic study of electron microscopic appearances of normal human colonic epithelium.The findings enable an interesting comparison to be made with jejunal epithelium and provide further data for a discussion of the filamentous network which extends from the surface of microvilli.The mucosal lining of the human large bowel has received little attention from electron microscopists.Ultrastructural studies of this tissue have been limited primarily to goblet cells in the mouse and rat (Shearman and Muir,
Abstract 3668: Inhibition of HSP90 with NVP-AUY922 induces a synergistic effect in HER2-amplified, trastuzumab-resistant breast and gastric cancer
Authors: Zev A. Wainberg, Amy Rogers, Neil O'Brien, Adrian Anghel, Amrita Desai, Ondrej Kalous, Dylan Conklin, Mikhail Akimov, Richard S. Finn, Dennis J. Slamon
Journal: Cancer Research (2012)

Abstract Background: Heat Shock Protein 90 (HSP90) enables the activation of a large number of client proteins of which the most clinically validated is HER2. NVP-AUY922 is a a highly potent, non-geldamycin HSP90 inhibitor that has shown preliminary activity in HER2 positive metastatic breast cancer. To explore its potential clinical utility specifically in HER2 amplified gastric and breast cancers, we evaluated the effect of AUY922 alone and in combination with trastuzumab in both trastuzumab-sensitive and resistant in vitro and in vivo models. Methods: A panel of 16 human gastric and 45 breast cancer cell lines, with 3 and 13 HER2-amplified lines respectively, were exposed in vitro to AUY922 over various concentrations to generate dose response curves. In both breast and gastric cancer, we used cell lines and xenograft models with conditioned trastuzumab-resistance to investigate the efficacy of AUY922 alongside trastuzumab. In all in vivo experiments, trastuzumab was dosed at 10 mg/kg (IP; twice/week) and AUY922 at 50 mg/kg, (IP; 5 days on, 2 days off). Effects of this combination on downstream markers (HER2, AKT, ERK) were analyzed via western blot. Results: AUY922 was found to have potent anti-proliferative activity in the low nanomolar range (&amp;lt; 40 nM) for 59 of the 61 gastric and breast cancer cell lines tested. Additionally, in both gastric and breast cancer, HER2-amplified cells expressed greater sensitivity to the compound when compared to the HER2-negative cells. In conditioned trastuzumab-resistant cell line models, AUY922 continued to have potent activity and exhibited a synergistic effect with trastuzumab. The in vitro combination also induced greater decreases in HER2, induced a G0/G1 cell cycle arrest, and increased the rates of apoptosis. In a conditioned trastuzumab-resistant gastric cancer in vivo model (N87-Res), the combination of AUY922 and trastuzumab showed greater anti-tumor efficacy than either drug alone. Conclusions: These data suggest that AUY922 in combination with trastuzumab has unique efficacy in trastuzumab-resistant models. The combination of HSP90 inhibitors and trastuzumab represents a novel approach to the treatment of HER2 amplified cancers. Clinical trials combining AUY922 and trastuzumab in HER2 amplified breast and gastric cancers are currently ongoing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3668. doi:1538-7445.AM2012-3668
Obstructive sleep apnoea in acromegaly: the role of craniofacial changes
Authors: W. Hochban, K Ehlenz, R Conradt, U Brandenburg
Journal: European Respiratory Journal (1999)

Obstructive sleep apnoea (OSA) is due to craniofacial changes and acromegaly. The question addressed by this study was whether growth hormone (GH) induced craniofacial changes might explain persisting OSA despite endocrine inactivity in acromegaly. Nineteen patients treated for acromegaly were examined cephalometrically for craniofacial changes and polysomnographically for OSA. Twelve patients proved to have OSA with an apnoea/hypopnoea index &gt;15; seven patients showed no evidence of OSA at all. With respect to the endocrinological parameters, there were no differences between the two groups that would explain the presence or absence of OSA. Neither group differed with respect to sex, age, or body mass index. Craniofacial changes were predominantly found in the mandible. The group with OSA proved to have increased vertical, dolichofacial growth compared to those without OSA. Consecutively, in the OSA group the posterior airway space was narrowed, and the hyoid was displaced more caudally. Thus, it seems that craniofacial structures of patients with acromegaly and persisting obstructive sleep apnoea are different from those without obstructive sleep apnoea. Surgical corrections of pertaining acromegaly-induced craniofacial changes should be performed with an awareness of the individual craniofacial condition so as not to enhance obstructive sleep apnoea.
BMA meeting: Trainee GPs face job shortage after qualifying
Authors: A. Cole
Journal: BMJ (2008)

“Large numbers” of trainee GPs are finding a lack of jobs to apply for when they qualify, representatives at the BMA’s annual meeting heard on Monday.

Members agreed to press the association to carry out an immediate investigation into the number of trainees in this situation, the number retiring, and the supply of substantive posts.

They also called for a media campaign to highlight the “plight of unemployed, fully qualified general practitioners.”

Alex Smallwood, from the Junior Doctors Committee, said that about 2300 trainee GPs were coming through each year and that this was set to rise to 3100. But anecdotal evidence indicated that the number of jobs advertised was 400-500 short of this figure.

And despite pressure …
Coronary artery bypass grafting without cardiopulmonary bypass and without interruption of native coronary flow using a novel anastomosis site restraining device (“Octopus”)
Authors: Cornelius Borst, Erik W.L. Jansen, Cornelis A.F. Tulleken, Paul F. Grundeman, Hendricus J. Mansvelt Beck, Jeroen W.F. van Dongen, Kees C. Hodde, Jaap J. Bredée
Journal: Journal of the American College of Cardiology (1996)
Cardiovascular Pathology in Hyperlipoproteinemia (HLP).
Authors: William C. Roberts
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Cardiovascular Pathology in Hyperlipoproteinemia (HLP).William C. Roberts, M.D., Victor J. Ferrans, M.D., Robert I. Levy, M.D., F.A.C.P., Donald S. Fredrickson, M.D., F.A.C.P.William C. Roberts, M.D.Search for more papers by this author, Victor J. Ferrans, M.D.Search for more papers by this author, Robert I. Levy, M.D., F.A.C.P.Search for more papers by this author, Donald S. Fredrickson, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-820_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLittle information is available on the morphologic aspects of hyperlipoproteinemia. To begin to fill this void 28 patients known to have this disorder and 14 with normal lipoprotein patterns were studied at necropsy. Of the 42 patients, 28 had symptomatic ischemic heart disease—20 of these had hyperlipoproteinemia (type II, 9; type III, 2; type IV, 9), and 8 had normal lipoproteins. The average age at death in the 20 patients with hyperlipoproteinemia and symptomatic heart disease was 48 years; in the 8 with normal lipoproteins, 46 years. The degree of coronary arterial luminal narrowing was severe in all with heart... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William C. Roberts, M.D.; Victor J. Ferrans, M.D.; Robert I. Levy, M.D., F.A.C.P.; Donald S. Fredrickson, M.D., F.A.C.P.Affiliations: Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5 Page: 820-820 Keywords Cardiovascular therapy Heart Lipoproteins ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
Hepatitis B virus–specific T-cell proliferation and cytokine secretion in chronic hepatitis B e antibody–positive patients treated with ribavirin and interferon alfa
Authors: Miguel A. Rico, Juan Antonio Quiroga, Dolores Subirá, Susana Castañón, José Miguel Esteban, Margarita Pardo, Vicente Carreño
Journal: Hepatology (2001)

Immune elimination of hepatitis B virus (HBV) during antiviral therapy depends on the activation of T–cell responses, which are generally impaired in chronic hepatitis B. HBV–specific T helper (Th)–cell reactivity has been assessed post–treatment in liver and peripheral blood of 18 anti–HBe–positive patients with chronic hepatitis B administered combined ribavirin/interferon alfa (IFN–α) therapy. The results showed that patients with undetectable HBV DNA by quantitative polymerase chain reaction under combination therapy were able to mount an HBV–specific CD4 + Th–cell proliferative response and such T–cell reactivity is detectable 1 year after HBV DNA clearance. Hepatitis B virus core (HBcAg) and e (HBeAg) antigen–specific Th–cell proliferation was found more frequently in the liver and peripheral blood in those patients who sustained the alanine aminotransferase (ALT) normalization together with HBV DNA loss. However, HBV–specific IFN–γ production in vitro in peripheral blood mononuclear cells augmented in 4 of 5 sustained responders and all 13 nonresponders, interleukin 10 (IL–10) production decreased in all 5 sustained responders but increased in 7 of 13 nonresponders. Furthermore, intrahepatic HBcAg plus HBeAg–specific Th–cell proliferation only occurred in sustained responders (2 of 3, 67%, vs. 0 of 9; P = .045) whose cells showed in vitro significantly increased productions in HBcAg/HBeAg–specific IFN–γ and IL–12 compared with nonresponders in whom IFN–γ and IL–12 productions decreased together with increased IL–10 secretion. In conclusion this study indicates that combined therapy with ribavirin and IFN–α for chronic hepatitis B not only significantly reduces viremia levels but also induces lasting CD4 + T–cell proliferation and Th1 cytokine release at the site of infection, which may lead to sustained eradication of the HBV.
Characterization of l-leucine transport system in brush border membranes from human and rabbit small intestine
Authors: P. Iannoli, J.H. Miller, H.T. Wang, B. Bode, W.W. Souba, N.E. Avissar, H.C. Sax
Journal: Metabolism (1999)

The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are beneficial to catabolic patients by improving hepatic protein synthesis and nitrogen economy, yet their transport from the intestinal lumen is not well-defined. The leucine transport system in human and rabbit small intestine was characterized using a brush border membrane vesicle (BBMV) model. Sodium and pH dependence and transport activity along the longitudinal axis of the small bowel were determined. Transport kinetics and inhibition profiles were defined. Although previous studies in other tissues show leucine transport to be mostly a Na+-independent process, our studies show that leucine transport is a predominantly Na+-dependent process occurring mainly via a single saturable pH-independent transporter resembling system B0 in the intestine. This system B0 transporter demonstrates stereoisomeric specificity. There is also a minor Na+-independent transport component (<6% in rabbits). Leucine uptake in both rabbits and humans is significantly greater than the uptake of other clinically relevant nutrients such as glutamine. In the rabbit, ileal leucine transport is significantly greater than jejunal uptake. While the affinities of the human and rabbit transporters are similar, the rabbit transporter has greater carrier capacity (maximal transport velocity [Vmax]). These findings suggest that the transport of leucine in the gut mucosa is significantly different from the transport in other tissues.