tbuckley/cabot-search huggingface dataset:
An elected Libyan government should restore order to the health system
Authors: I. M. Hajjaji
Journal: BMJ (2011)

“There are tanks on the streets. Get up! Get up!” cried my mother on 1 September 1969. So started Lieutenant Muammar Gaddafi’s coup d’etat. I was 10 years old and attending an English school in Tripoli. Within two years the ruling military council closed foreign language schools, and I was rushed to a boarding school in Kent because the school year was starting two weeks later. Libya, then with a population of three million, became wealthy in the 1970s as the price of oil shot up. Modern hospitals were built, foreign staff were employed, and the first medical were schools opened in Benghazi and then Tripoli. Doctors were sent abroad for postgraduate training.

Matters began to take a different path in the 1980s. Public executions, imprisonment, and forced military conscription became widespread. Though healthcare was free, there was a noticeable decline in standards. The “revolutionary committees”—groups of zealots who were often violent—were present in hospitals, clinics, and universities.

I went to medical school at Trinity College, Dublin and then returned to the UK to do senior …
CHRONIC GALLBLADDER DISEASE IN THE YOUNG ADULT
Authors: ARTHUR T. MANN
Journal: JAMA (1924)

The basis for this paper is a series of fifty-seven cases of chronic gallbladder disease in young adults, operated on in the early stages of the disease, with no mortality. All of these patients have improved, and most of them have lost their symptoms. We have been particularly interested in the early manifestations of chronic cholecystitis. We have come to feel that, before our study of the series from which these cases were selected and before our study of the pathologic findings in these cases, we commonly missed the diagnosis of a surgical condition of the gallbladder until the patient was in the late stages of gallbladder disease. We find that, as our cases have multiplied, we have been making the diagnosis of chronic cholecystitis earlier, and with increasing confidence.  These fifty-seven cases were selected after a restudy of a larger series of obscure cases presenting persistent abdominal symptoms, all
TCT-426 Our Experience With Absorb Everolimus Eluting Bioresorbable Vascular Scaffold in All Comers with Coronary Artery Disease -"Real Absorb Registry".
Authors: Ashok Seth, Vinayak Ravisekar, Vishal Rastogi, Vijay Kumar, Upendra Kaul, Atul Mathur, Praveer Agarwal, Vinay Sanghi
Journal: Journal of the American College of Cardiology (2013)
FDG Avid Patchy Bone Marrow Misinterpreted As Melanoma Metastases to Bone in a Case of Aplastic Anemia
Authors: Chio Okuyama, Takao Kubota, Shigenori Matsushima, Kaori Nishida, Minori Oda, Hideya Takenaka, Saburo Kishimoto, Tsunehiko Nishimura
Journal: Clinical Nuclear Medicine (2009)

A 65-year-old woman with resected melanoma underwent F-18 Fluorodeoxyglucose (FDG) PET/CT for the evaluation of a metastatic lesion. Focal increased accumulations were seen in the marrow space of several bones, and interpreted as metastases. MRI demonstrated localized abnormal signal in the corresponding sites. Since she had also suffered from aplastic anemia, additional In-111 chloride bone marrow scintigraphy was performed, and it revealed that the sites with increased accumulation of FDG were consistent with the patchy hematopoietic marrow. FDG PET/CT in a patient with aplastic anemia showing foci of increased bone accumulation occasionally indicates patchy functional hematopoiesis.
Mixed sex wards.
Authors: D. S. Hadden, C. H. Dearden, G. Ross
Journal: BMJ (1992)

Mixed sex wards EDITOR,-Mixed sex wards exist in many hos- pitals,' but there are few studies of their acceptability to patients.We carried out a simple survey to determine patients' opinions before and after relocating the accident and emergency observation ward of this hospital from a ward with single sex six bed bays to a mixed sex Nightingale ward.The ward with single sex bays had separate toilets and washrooms for men and women; the mixed sex ward had shared toilets and washrooms, although the nurses tried to ensure that only men or women used these at any one time.Patients were aged over 13 and required observation or investigation for various acute problems.Most were discharged within 24 hours.
A Casualty of Indirect Costs: Stanford President Resigns; 270 Universities Face Probe
Authors: N. Volkers
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article A Casualty of Indirect Costs: Stanford President Resigns; 270 Universities Face Probe Get access Nancy Volkers Nancy Volkers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 18, 18 September 1991, Pages 1288–1289, https://doi.org/10.1093/jnci/83.18.1288 Published: 18 September 1991
The Origin and Characterization of New Nuclear Genes Originating from a Cytoplasmic Organellar Genome
Authors: A. H. Lloyd, J. N. Timmis
Journal: Molecular Biology and Evolution (2011)

Endosymbiotic transfer of DNA and functional genes from the cytoplasmic organelles (mitochondria and chloroplasts) to the nucleus has been a major factor driving the origin of new nuclear genes, a process central to eukaryote evolution. Although organelle DNA transfers very frequently to the nucleus, most is quickly deleted, decays, or is alternatively scrapped. However, a very small proportion of it gives rise, immediately or eventually, to functional genes. To simulate the process of functional transfer, we screened for nuclear activation of a chloroplast reporter gene aadA, which had been transferred from the chloroplast to independent nuclear loci in 16 different plant lines. Cryptic nuclear activity of the chloroplast promoter was revealed, which became conspicuous when present in multiple nuclear copies. We screened ∼50 million cells of each line and retrieved three plants in which aadA showed strong nuclear activation. Activation occurred by acquisition of the CaMV 35S nuclear promoter or by nuclear activation of the native chloroplast promoter. Two fortuitous sites within the 3' UTR of aadA mRNA both promoted polyadenylation without any sequence change. Complete characterization of one nuclear sequence before and after gene transfer demonstrated integration by nonhomologous end joining involving simultaneous insertion of multiple chloroplast DNA fragments. The real-time observation of three different means by which a chloroplast gene can become expressed in the nucleus suggests that the process, though rare, may be more readily achieved than previously envisaged.
Malaria patients should be tracked back to their homes to identify hot spots, expert says
Authors: G. Watts
Journal: BMJ (2011)

Progress in controlling malaria is encouraging some countries to consider the possibility of its elimination, said speakers at a briefing on 13 April organised by the London School of Hygiene and Tropical Medicine.

Malaria affects half the world’s population and still causes more than 700 000 deaths a year, so elimination is still a challenging goal for many countries. And in countries where the disease is receding, said Chris Drakeley, director of the school’s Malaria Centre, the remaining “hot spots” may prove hard to deal with.

Tackling these is vital, not least because in such hot spots resistance to antimalarial drugs …
Parahippocampal Hypoactivation and Vulnerability to Schizophrenia
Authors: Paul Allen, Philip K. McGuire
Journal: JAMA Psychiatry (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
STUDIES ON THE PSITTACOSIS-LYMPHOGRANULOMA GROUP
Authors: M. Michael Sigel, Anthony J. Girardi, Emma G. Allen
Journal: The Journal of Experimental Medicine (1951)

Because of the peculiar properties of the psittacosis-lymphogranuloma group of viruses, the pattern of multiplication in the allantois of the chick embryo of one of their number, meningopneumonitis virus, was studied. This was done by determination of the changes in its infectivity for mice and chick embryos. Titration of infectivity in embryos proved to be a more sensitive procedure than titration in mice; the latter procedure however, had the advantage of greater simplicity and gave more clear-cut results. The mouse titration method was used in most of the experiments. Following inoculation of virus into the allantois, there was a slow decrease in infectivity in the allantoic fluids followed by an increase due to appearance of new virus between 24 and 48 hours. The slope of declining infectivity in the allantoic fluids in ovo was similar if not identical with the slope of decreasing infectivity in allantoic fluids in vitro caused by thermal degradation of virus. Multiplication of the virus in allantoic membranes was characterized by the following pattern: (a) Increase in infectivity in the first few hours (exact duration of increase depended on concentration of virus in inoculum) due to adsorption of virus. (b) Decrease in infectivity up to about 20 to 24 hours. (c) Increase in infectivity due to appearance of the new generation of virus. The growth curve of meningopneumonitis is analyzed and the pattern of growth is discussed in the light of the present concepts of viral multiplication.
Immunofluorescence microscopy of healthy skin from patients with systemic lupus erythematosus: more than just the lupus band.
Authors: P J Velthuis, L Kater, I van der Tweel, H B de la Faille, W A van Vloten
Journal: Annals of the Rheumatic Diseases (1992)

Many papers have been published on the lupus band in systemic lupus erythematosus (SLE), but little information exists on the possible diagnostic value of the lupus band and other microscopic immunofluorescence phenomena found in clinically normal skin of patients with SLE. In a study of 297 subjects (66 patients with SLE, 81 patients with other forms of LE, and 150 patients with other systemic connective tissue disorders) it was found that: (a) granular deposits of IgA, IgG, and IgM in the basal membrane zone and in the deeper blood vessels were more common in patients with SLE than in the other two groups; (b) depending on the clinical differential diagnosis, IgA and IgG deposits at the epidermal basal membrane can be specific for SLE; (c) using logistic regression analysis sets of variables can be selected with a high potential to discriminate between SLE and the other groups; and (d) immunofluorescence variables do not duplicate the information for the diagnosis of SLE given by the American Rheumatism Association (ARA) criteria or other laboratory methods. From these results, it is concluded that immunofluorescence microscopy of clinically normal skin is a valuable diagnostic method which should be reconsidered as a potential criterion for the diagnosis of SLE in the next evaluation of the ARA criteria.
Perceptual Challenge to Measure Illness and Therapy
Authors: AMEDEO S. MARRAZZI, SHARON WOODRUFF, DENIS KENNEDY
Journal: American Journal of Psychiatry (1972)

The dissociation produced in the auditory modality by a challenge with LSD can be quantitated by an instrumental perception test. Chlorpromazine can protect against this dissociation, and its efficacy can be measured by changes in auditory perception. The author describes this quantitative instrumental procedure. which is being developed into a "clinical yardstick" to measure dissociative mental dysfunction and illness, its intensity, and its response to therapy.
Metacognitive Therapy versus Exposure and Response Prevention for Pediatric Obsessive-Compulsive Disorder
Authors: Michael Simons, Silvia Schneider, Beate Herpertz-Dahlmann
Journal: Psychotherapy and Psychosomatics (2006)

&lt;i&gt;Background:&lt;/i&gt; Exposure with ritual prevention (ERP) is the psychotherapeutic treatment of choice for pediatric obsessive-compulsive disorder (OCD). In the present study, a new treatment rationale – metacognitive therapy (MCT) for children – was developed and evaluated. &lt;i&gt;Methods:&lt;/i&gt; Ten children and adolescents with OCD were randomly assigned to either MCT or ERP therapy condition. Patients were assessed before and after treatment and at the 3-month and 2-year follow-up by means of symptom severity interviews. Depressive symptoms were also assessed. Manualized treatment involved up to 20 sessions on a weekly basis. &lt;i&gt;Results:&lt;/i&gt; We found clinically and statistically significant improvements in symptom severity after treatment. At the 3-month and 2-year follow-up, the attained improvements during treatment were retained. &lt;i&gt;Conclusions:&lt;/i&gt;Despite some methodological limitations, results showed that MCT proved to be a promising psychotherapeutic alternative to the well-established ERP in the treatment of pediatric OCD. Further investigations into the efficacy of MCT are necessary to answer questions as to the working mechanisms underlying therapy for OCD.
Paraben Contact Dermatitis
Authors: Kirk D. Wuepper
Journal: JAMA (1967)

Four cases of allergic contact sensitivity to alkyl esters of<i>p</i>-hydroxybenzoic acid (parabens) were detected during routine closed patch tests on 91 patients with contact dermatitis. All four patients had refractory dermatitis of unknown cause and all were using topical medications containing parabens as preservative. Cross-sensitivity was demonstrated in additional tests with parabens in a concentration of 5%. Positive reactions to<i>p</i>-hydroxybenzoic acid were also obtained by patch test (one patient) and by intradermal injection (one patient).
Congenital Deficiency of Fibrin-Stabilizing Factor
Authors: Muhammad Zahir
Journal: JAMA (1969)

A 3-year-old girl had a deficiency in fibrin-stabilizing factor (factor XIII). Although approximately 18 cases of this disorder have been reported in the world literature, the present case is of interest for three reasons: (1) A factor XIII level of 1% to 2% was sufficient to correct the defect in the patient's plasma. (2) There was a history of intermarriage between relatives in the patient's family. (3) A partial deficiency of factor XIII was demonstrated in the patient's parents and in some of the other members of her family.
Innate immune lectins kill bacteria expressing blood group antigen
Authors: Sean R Stowell, Connie M Arthur, Marcelo Dias-Baruffi, Lilian C Rodrigues, Jean-Philippe Gourdine, Jamie Heimburg-Molinaro, Tongzhong Ju, Ross J Molinaro, Carlos Rivera-Marrero, Baoyun Xia, David F Smith, Richard D Cummings
Journal: Nature Medicine (2010)
The Clinical Use of Chlorambucil
Authors: Daniel G. Miller, Henry D. Diamond, Lloyd F. Craver
Journal: New England Journal of Medicine (1959)

CHLORAMBUCIL (P-[di-2-chloroethylamino]-phenylbutyric acid, or CB 1348) is an analogue of nitrogen mustard that may be administered orally. There have been several reports attesting to its usefulness in the treatment of patients with lymphoma and chronic lymphocytic leukemia.1 2 3 4 5 A considerable experience has been accumulated at the Memorial Center for Cancer and Allied Diseases with nitrogen mustard6 and triethylene melamine,7 and it was against this background that the study of the use of chlorambucil was made.To evaluate the use of chlorambucil, particular attention was paid to specific points of administration and response such as the value of maintenance therapy, combination therapy . . .
27 IMPACT OF DIFFERENTIALLY EXPRESSED MICRORNAS ON MYOFIBROBLASTIC TRANSDIFFERENTIATION OF HEPATIC STELLATE CELLS
Authors: I. Strack, S. Schievenbusch, J. Riemer, M. Kwiecinski, A. Noetel, M. Scheffler, I. Wedemeyer, H.P. Dienes, M. Odenthal
Journal: Journal of Hepatology (2009)
DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice
Authors: Zongchao Han, Shannon M. Conley, Rasha S. Makkia, Mark J. Cooper, Muna I. Naash
Journal: Journal of Clinical Investigation (2012)

Mutations in the photoreceptor-specific flippase ABCA4 are associated with Stargardt disease and many other forms of retinal degeneration that currently lack curative therapies. Gene replacement is a logical strategy for ABCA4-associated disease, particularly given the current success of traditional viral-mediated gene delivery, such as with adeno-associated viral (AAV) vectors. However, the large size of the ABCA4 cDNA (6.8 kbp) has hampered progress in the development of genetic treatments. Nonviral DNA nanoparticles (NPs) can accommodate large genes, unlike traditional viral vectors, which have capacity limitations. We utilized an optimized DNA NP technology to subretinally deliver ABCA4 to Abca4-deficient mice. We detected persistent ABCA4 transgene expression for up to 8 months after injection and found marked correction of functional and structural Stargardt phenotypes, such as improved recovery of dark adaptation and reduced lipofuscin granules. These data suggest that DNA NPs may be an excellent, clinically relevant gene delivery approach for genes too large for traditional viral vectors.
Radionuclide Imaging of Relapsing Polychondritis
Authors: CHIA HUNG KAO, SHYH-JEN WANG, SHIH-HWA YEH
Journal: Clinical Nuclear Medicine (1992)

The authors describe the scintigraphic findings of relapsing polychondritis using Tc-99m MDP bone scans and Ga-67 citrate scintigrams of a 49-year-old man with erythematous swelling of both ear auricles, nasal deformity, and pain in the thyroid cartilage and small joints of both hands.
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes
Authors: Yuka Harada, Daichi Inoue, Ye Ding, Jun Imagawa, Noriko Doki, Hirotaka Matsui, Takashi Yahata, Hiromichi Matsushita, Kiyoshi Ando, Goro Sashida, Atsushi Iwama, Toshio Kitamura, Hironori Harada
Journal: Blood (2013)
Clinical stage draws nearer in ongoing studies of gene therapy
Authors: Kathryn Simmons
Journal: JAMA (1985)

It may be a matter of three years or less before clinical trials are undertaken for the study of gene therapy of inherited disease. That is the estimation of C. Thomas Caskey, MD, director of the Robert J. Kleberg, Jr, Center for Human Genetics at Baylor College of Medicine, Houston. It is an opinion shared by numerous other investigators. (Two unsuccessful attempts to undertake gene transfer involving women with β<sup>0</sup>-thalassemia were performed abroad in 1980 by Martin J. Cline, MD, of the University of California, Los Angeles, School of Medicine. Although Cline had permission of the local hospitals abroad to perform the experiments, the UCLA institutional review board rejected his proposal on the grounds that further animal studies were needed, and he lost his National Institutes of Health grants.) Caskey, who spoke at the annual Short Course in Medical and Experimental Mammalian Genetics in Bar Harbor, Me, which
PERSISTENCE OF IMMUNOGENICITY OF ANTIGEN AFTER UPTAKE BY MACROPHAGES
Authors: Emil R. Unanue, Brigitte A. Askonas
Journal: The Journal of Experimental Medicine (1968)

Peritoneal macrophages were cultured for several hours after uptake of (131)I-hemocyanin. The cells degraded most of the (131)I-labeled protein within 2-5 hr. Their ability to prime lymphocytes of syngeneic mice for a secondary immune challenge remained unchanged for long periods of time despite the loss of more than 90% of the original content of antigen. The persistence of immunogenicity was associated with a small percentage of antigen retained by the cell in a form which was protected from rapid breakdown and elimination.
In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib
Authors: Jamshid S. Khorashad, Dragana Milojkovic, Puja Mehta, Mona Anand, Sara Ghorashian, Alistair G. Reid, Valeria De Melo, Anna Babb, Hugues de Lavallade, Eduardo Olavarria, David Marin, John M. Goldman, Jane F. Apperley, Jaspal S. Kaeda
Journal: Blood (2007)
Gastroesophageal reflux disease and asthma: an intriguing dilemma
Authors: C. Astarita, D. Gargano, M. Cutajar, A. Napolitano, F. Manguso, G. F. Abbate
Journal: Allergy (2000)

Gastroesophageal reflux disease (GORD) is characterized by typical reflux symptoms and multiple atypical extraesophageal symptoms. Gastric asthma is a prominent extraesophageal manifestation of GORD. There is persistent debate about the pathophysiologic mechanisms triggering asthma by GOR.We conducted a review of the literature.The pathogenic mechanism could be either a vagally transmitted reflex or an intratracheal aspiration of refluxed material. In both hypotheses, the role of inflammatory mediators has been proposed.Neurogenic inflammation is a good theoretic basis for a pathogenic interpretation of the disorder. In atopic patients, food allergy has been recently proposed as a possible cause of GOR and associated respiratory symptoms, and it should be considered in the diagnostic work-up of all patients with GORD.
Congenital Hypothyroidism Control Programs
Authors: Peter M. Layde
Journal: JAMA (1979)

Comprehensive screening programs to control congenital hypothyroidism (CH), a preventable form of mental retardation, are being considered by some public health agencies. The proposed programs would test neonates' blood for thyroxine and, if warranted, provide follow-up testing and therapy. The estimated cost of detecting a single case of CH is $9,300, which includes specimen collection, laboratory analysis, and retesting of border-line cases. The present value of the treatment costs for CH adds $2,500 per case, a total cost of $11,800 per case detected and child treated. The economic benefits (averted costs of institutionalization and special education and increased productivity of the affected person) are estimated to have a present value of $105,000 per case, yielding a cost-benefit ratio of 1:8.9. (<i>JAMA</i>241:2290-2292, 1979)
Private health sector in India
Authors: T D Rajan
Journal: BMJ (2005)

Editor—Sengupta and Nundy argue that the private health sector in India is burgeoning at the expense of public health care,1 but the two issues cannot be muddled together.​together.




Figure 1



Credit: BELINDA LAWLEY/PANOS




We cannot wait for potable drinking water and electricity to reach every village before we design and build rockets. Development in different areas should proceed simultaneously, and this should be borne in mind in the healthcare industry. Foreign exchange earned by medical tourism will certainly boost India's economy, which will in turn raise the standard of healthcare systems. What is needed is a systematic approach to make sure that a part of the funds earned is channelled to primary health care.

Raising the allocation in the budget for health is definitely called for, but not at the cost of a new source of national income.