tbuckley/cabot-search huggingface dataset:
Abstract P4-16-02: EF24 targets radiation-induced NFkB-dependent stemness in triple negative breast cancer cells
Authors: SK Ramraj, M Natarajan, S Aravindan, TS Herman, N Aravindan
Journal: Cancer Research (2013)

Abstract Prognosis of patients with late stage BCa still remains poor, mostly due to development of chemoradioresistance followed by tumor recurrence. Cancer stem cells (CSCs), with higher drug efflux capability, and other stem cell-like properties were proposed to be responsible for resistance, relapse and progression of BCa. We have shown that EF24 alleviates radiation (IR)-orchestrated NFkB mediated clonal expansion. Herein, we investigated the potential of EF24 in the regulation of IR-induced NFkB dependent stemness in triple negative breast cancer cells (TNBC). MDA-MB-231 cells exposed to mock-IR or IR (2Gy) with/without EF24 were examined for transcriptional alterations of 93 EMT, CSCs self-renewal, pluoripotentcy maintenance and other stem cell markers. NFkB (p50/p65) overexpression (with or without EF24) and RelA siRNA knockout (with IR) approach were used to delineate the role of IR-induced NFkB and the selective NFkB targeting of EF24 in this setting. Nanog, Sox-2, ABCG-2, N-Cadherin, POU5F1 and Myc expression was examined with immunoblotting. IR profoundly increased the transactivation of 86 stem-cell related molecules in TNBCs that are involved in cell survival. Interestingly, muting IR-induced NFkB attenuated 85 of those genes. Notably, EF24 suppressed identical 85 genes reproducing the inhibitory signature of NFkB muting. Coherently, activating NFkB induced 87 stem-cell related molecules in TNBC and of which 86 genes were completely suppressed with EF24. Alterations in the cellular expression levels of Nanog, Sox-2, ABCG-2, N-Cadherin, POU5F1 and Myc validates the potential of EF24 in mitigating IR-induced stemness in TNBC. Together these data demonstrates, at least in TNBC cells, IR-induced NFkB mediates increased stem-like characteristics and further imply that EF24 may alleviate stemness by selectively targeting IR-induced NFkB. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-16-02.
Colonoscopy and fecal occult blood test use in Germany: results from a large insurance-based cohort
Authors: C. Stock, P. Ihle, I. Schubert, H. Brenner
Journal: Endoscopy (2011)

Background and study aims: Colonoscopy and guaiac-based fecal occult blood tests (FOBT) are recommended and offered for colorectal cancer (CRC) screening in Germany. We aimed to explore their utilization in a large insurance-based cohort.
BMA backs GPs in their objections to financial incentives to limit hospital referrals
Authors: L. Eaton
Journal: BMJ (2008)

The BMA is supporting GPs in Oxfordshire in their objections to attempts by their local primary care trust to limit the number of hospital referrals.

The trust is offering general practices a financial reward if they hit a target for reducing their referrals to avert a possible overspend of £23m (€29m; $36m). But doctors fear that this approach may undermine patient confidence in their clinical decision making.

The policy was introduced at the beginning of October after several weeks’ discussion with local GPs. There are two elements to the deal. In the first GPs are paid to consult with other doctors in their practice about non-urgent cases before deciding whether or not to refer the patient. They are paid for 4-5 hours a week for this and an average practice of 10 000 …
Project retrains prostitutes as care workers for elderly people
Authors: Katy Duke
Journal: BMJ (2006)

A new project in Germany is retraining prostitutes to become care workers for elderly people.

The state of North Rhine-Westphalia is using €1m (£0.7m; $1.2m) of local and European Union money to try to get sex trade workers off the street and into care homes.

Heinz Oberlach, from Germany's Federal Labour Agency, said that using prostitutes as care workers is “very logical,” as the nursing home sector is seriously understaffed and has some 6400 vacancies nationwide—despite a national unemployment rate of 12% in Germany. Reasons for the shortage include a recent clampdown on Eastern Europeans working illegally as care workers and the reluctance of Germans …
Angiotensin Receptor Agonistic Autoantibody–Mediated Tumor Necrosis Factor-α Induction Contributes to Increased Soluble Endoglin Production in Preeclampsia
Authors: Cissy Chenyi Zhou, Roxanna A. Irani, Yujin Zhang, Sean C. Blackwell, Tiejuan Mi, Jiaming Wen, Harnath Shelat, Yong-Jian Geng, Susan M. Ramin, Rodney E. Kellems, Yang Xia
Journal: Circulation (2010)

Preeclampsia is a prevalent life-threatening hypertensive disorder of pregnancy. The circulating antiangiogenic factor, soluble endoglin (sEng), is elevated in the blood circulation of women with preeclampsia and contributes to disease pathology; however, the underlying mechanisms responsible for its induction in preeclampsia are unknown.Here, we discovered that a circulating autoantibody, the angiotensin receptor agonistic autoantibody (AT(1)-AA), stimulates sEng production via AT(1) angiotensin receptor activation in pregnant mice but not in nonpregnant mice. We subsequently demonstrated that the placenta is a major source contributing to sEng induction in vivo and that AT(1)-AA-injected pregnant mice display impaired placental angiogenesis. Using drug screening, we identified tumor necrosis factor-alpha as a circulating factor increased in the serum of autoantibody-injected pregnant mice contributing to AT(1)-AA-mediated sEng induction in human umbilical vascular endothelial cells. Subsequently, among all the drugs screened, we found that hemin, an inducer of heme oxygenase, functions as a break to control AT(1)-AA-mediated sEng induction by suppressing tumor necrosis factor-alpha signaling in human umbilical vascular endothelial cells. Finally, we demonstrated that the AT(1)-AA-mediated decreased angiogenesis seen in human placenta villous explants was attenuated by tumor necrosis factor-alpha-neutralizing antibodies, soluble tumor necrosis factor-alpha receptors, and hemin by abolishing both sEng and soluble fms-like tyrosine kinase-1 induction.Our findings demonstrate that AT(1)-AA-mediated tumor necrosis factor-alpha induction, by overcoming its negative regulator, heme oxygenase-1, is a key underlying mechanism responsible for impaired placental angiogenesis by inducing both sEng and soluble fms-like tyrosine kinase-1 secretion from human villous explants. Our results provide important new targets for diagnosis and therapeutic intervention in the management of preeclampsia.
Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer
Authors: Takeshi Isobe, Amir Onn, Daniel Morgensztern, Jörg J. Jacoby, Wenjuan Wu, Tomoaki Shintani, Satoshi Itasaka, Keiko Shibuya, Peter J. Koo, Michael S. O'Reilly, Roy S. Herbst
Journal: Journal of Thoracic Oncology (2013)
Mutations in a Thiamine-Transporter Gene and Wernicke's-like Encephalopathy
Authors: Satoshi Kono, Hiroaki Miyajima, Kenichi Yoshida, Akashi Togawa, Kentaro Shirakawa, Hitoshi Suzuki
Journal: New England Journal of Medicine (2009)

To the Editor: We report on two previously healthy Japanese brothers with a newly discovered recessively inherited syndrome similar to Wernicke's encephalopathy that developed in the second decade ...
Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.
Authors: A M Kruisbeek, M J Fultz, S O Sharrow, A Singer, J J Mond
Journal: The Journal of Experimental Medicine (1983)

Monoclonal antibodies to I-Ak were injected into neonatal H-2k mice for a period of 3 wk. The spleens of such mice are devoid of Ia-positive cells. Allo- and trinitrophenyl (TNP)-self-specific cytotoxic T lymphocyte (CTL) responses in such anti-I-A-treated mice were almost completely abrogated at the end of the 2-3 wk in vivo treatment period. Development of suppressor cells, carry-over of blocking antibodies, lack of responder accessory cells, or defective CTL function were not responsible for the observed defect. As concanavalin A supernatant could restore the defect, it is more likely that the defect is due to the absence of competent Ia-specific T helper cells. In addition, anti-I-A-treated mice exhibit reduced I-A antigen expression in the thymus and defective Ia-bearing accessory cell function in the spleen. It is postulated that, for development of Ia-specific T cells to occur, precursor T cells need to interact with Ia-encoded products in the thymus, and anti-Ia treatment interferes with this process. Finally, the mechanism of this interference was shown to be due to actual removal or functional inactivation of those I-A-positive elements responsible for the education of I-A-recognizing T cells, since in (H-2b X H-2k)F1 mice, treatment with anti-I-Ak antibodies results in abrogation of CTL responses to TNP in association with both parental haplotypes, while in the thymus of these mice expression of both I-Ak and I-Ab was reduced.
Molecular Cancer Phenotype in Normal Prostate Tissue
Authors: Thorsten Schlomm, Olaf J.C. Hellwinkel, Andreas Buness, Markus Ruschhaupt, Andreas M. Lübke, Felix K. Chun, Ronald Simon, Lars Budäus, Andreas Erbersdobler, Markus Graefen, Hartwig Huland, Annemarie Poustka, Holger Sültmann
Journal: European Urology (2008)
Chickenpox in pregnancy. Incidence underestimated.
Authors: D S Sloan
Journal: BMJ (1993)

Recently we treated a 42 year old man with bowel obstruction at multiple sites due to advanced colonic carcinoma.A course of high dose steroids given eight months previously for radiotherapy induced emesis had resulted in a rapid evolution of a hypomanic state with complete insomnia.While treating him with steroids for his obstruction4 we infused 12mg of dexamethasone during the day and substituted a low dose of midazolam infusion at night.On this regimen his insomnia or hypomania did not recur and his bowel obstruction resolved on day 12.When he was converted to oral medication, diazepam 10mg was substituted for midazolam at night and he continued to sleep well.Sleep disturbance is not one of the best known side effects of steroids, but insomnia has medical and social sequelae that require recognition and action.Appropriate prescribing even in the most difficult cases may allow the patient enormous benefit from steroids and a good night's sleep.
Slow recovery of conduction velocity from use dependent inhibition induced by quinidine in guinea pig ventricular myocardium
Authors: J. Hasegawa, T. Nawada, S. Hirai, Y. Kurata, K. Ogino, H. Kotake, H. Mashiba
Journal: Cardiovascular Research (1991)

Journal Article Slow recovery of conduction velocity from use dependent inhibition induced by quinidine in guinea pig ventricular myocardium Get access Junichi Hasegawa, Junichi Hasegawa J Hasegawa, T Nawada, S Hirai, Y Kurata, K Ogino, H Kotake, H Mashiba, Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi Yonago 683, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Takahiro Nawada, Takahiro Nawada J Hasegawa, T Nawada, S Hirai, Y Kurata, K Ogino, H Kotake, H Mashiba, Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi Yonago 683, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Shozo Hirai, Shozo Hirai J Hasegawa, T Nawada, S Hirai, Y Kurata, K Ogino, H Kotake, H Mashiba, Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi Yonago 683, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasutaka Kurata, Yasutaka Kurata J Hasegawa, T Nawada, S Hirai, Y Kurata, K Ogino, H Kotake, H Mashiba, Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi Yonago 683, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Kazuhide Ogino, Kazuhide Ogino J Hasegawa, T Nawada, S Hirai, Y Kurata, K Ogino, H Kotake, H Mashiba, Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi Yonago 683, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroshi Kotake, Hiroshi Kotake J Hasegawa, T Nawada, S Hirai, Y Kurata, K Ogino, H Kotake, H Mashiba, Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi Yonago 683, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroto Mashiba Hiroto Mashiba J Hasegawa, T Nawada, S Hirai, Y Kurata, K Ogino, H Kotake, H Mashiba, Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi Yonago 683, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 25, Issue 4, April 1991, Pages 302–308, https://doi.org/10.1093/cvr/25.4.302 Published: 01 April 1991 Article history Received: 08 March 1990 Accepted: 22 November 1990 Published: 01 April 1991
The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial
Authors: Magdalena Madero, Julio C. Arriaga, Diana Jalal, Christopher Rivard, Kim McFann, Oscar Pérez-Méndez, Armando Vázquez, Arturo Ruiz, Miguel A. Lanaspa, Carlos Roncal Jimenez, Richard J. Johnson, Laura-Gabriela Sánchez Lozada
Journal: Metabolism (2011)
Influence of skin closure technique on surgical site infection after loop ileostomy reversal: Retrospective cohort study
Authors: C.D. Klink, M. Wünschmann, M. Binnebösel, H.P. Alizai, A. Lambertz, G. Boehm, U.P. Neumann, C.J. Krones
Journal: International Journal of Surgery (2013)
Gender affects 13C-Ketoisocaproic breath test for liver mithocondrial function
Authors: M. Candelli, A. Armuzzi, E.C. Nista, M.A. Zocco, A. Grieco, L. Miele, P. Pola, G. Gasbarrini, A. Gasbarrini
Journal: Journal of Hepatology (2001)
Paralysis of the Phrenic Nerve Following Herpes Zoster
Authors: Gerald W. Parker
Journal: JAMA (1962)

IN 1866 Sir William Broadbent described a case of "herpetic eruption in the course of branches of the brachial plexus, followed by partial paralysis in corresponding motor nerves." Since his original communication, several accounts of motor weakness accompanying herpes zoster have appeared, including the excellent review by Taterka and O'Sullivan in 1943. Generally, motor manifestations are confined to segments corresponding to the dermatomes in which the cutaneous lesions appear. It is believed that they result from an involvement of the anterior horn cells. To our knowledge, herpetic paralysis of the diaphragm has been reported only once previously. Our case is presented not only because of its rarity but also to emphasize the motor phenomena which may accompany some herpes zoster infections. Report of a Case A 60-year-old Puerto Rican woman was seen as an outpatient on July 18, 1960, because of severe superficial pain over the left shoulder, neck, and
Crowned Dens Syndrome Diagnosed on 18F-FDG PET/CT
Authors: Antoine Monet, Richard Massonnat, Bertrand Merino, Annalisa Riviere, Christophe Richez
Journal: Clinical Nuclear Medicine (2014)

An 87-year-old woman with corticosteroid-resistant polymyalgia rheumatica underwent ¹⁸F-FDG PET/CT for suspected giant cell arteritis or neoplastic disease. FDG uptake in the immediate vicinity of the odontoid process, with a crownlike calcification, was identified on the CT scan on the posterior side of the dens, thus confirming the diagnosis of crowned dens syndrome. Because this rare syndrome is frequently misdiagnosed, nuclear physicians should be aware of the signs and symptoms of this condition, which may call for the use of PET/CT imagery.
CDC Names H1N1 Vaccine Priority Groups
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1924: The aurora kinase inhibitor CYC3 synergizes with low concentrations of paclitaxel in pancreatic cancer cells in vitro
Authors: Yao Lin, Ben-Fillippo Krippendorff, Jo Bramhall, Tashinga Bapiro, Frances Richards, Duncan Jodrell, Daniella Zheleva
Journal: Cancer Research (2012)

Abstract CYC3, an Aurora Kinase A specific inhibitor, suppresses the pancreatic cancer cell growth (72h GI50 2.4μM in MiaPaCa-2 cells and 1.95μM in Panc-1 cells), arrest the cells at M phase and induces apoptosis. In order to evaluate CYC3's clinical potential, we employed mathematical models and simulations to look for possible synergistic combinations of CYC3 with paclitaxel in MiaPaCa-2 and Panc-1 cells. We have identified low concentrations of paclitaxel (3nM) and CYC3 is synergistic in inhibiting pancreatic cell growth, achieving similar effects as high concentrations of paclitaxel (30nM). Liquid Chromatography-Mass Spectrometry (LC-MS) analysis shows that CYC3 does not alter the cellular uptake of paclitaxel, supporting a synergistic mechanism at molecular level. In addition, the combination of CYC3 with low concentration of paclitaxel (3nM) displays less myelotoxicity compared to high concentrations of paclitaxel (30nM) in colony formation assay using Colony Forming Unit of Granulocyte and Macrophage (CFU-GM) (60-70% vs 100% inhibition), suggesting a potentially safer but equally efficient application of paclitaxel in patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1924. doi:1538-7445.AM2012-1924
Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation–Induced Senescence of Human Mesenchymal Stem Cells
Authors: Daojing Wang, Deok-Jin Jang
Journal: Cancer Research (2009)

Abstract Human mesenchymal stem cells (hMSC) are critical for tissue regeneration. How hMSC respond to genotoxic stresses and potentially contribute to aging and cancer remain underexplored. We showed that ionizing radiation induced cellular senescence of hMSC over a period of 10 days, showing a critical transition between days 3 and 6. This was confirmed by senescence-associated β-galactosidase staining, protein expression profiles of key cell cycle regulators (retinoblastoma protein, p53, p21waf1/Cip1, and p16INK4A), and senescence-associated secretory phenotypes (interleukin-8, interleukin-12, GRO, and MDC). We observed dramatic cytoskeletal reorganization of hMSC through reduction of myosin-10, redistribution of myosin-9, and secretion of profilin-1. Using a SILAC-based phosphoproteomics method, we detected significant reduction of myosin-9 phosphorylation at Ser1943, coinciding with its redistribution. Importantly, through treatment with cell-permeable inhibitors (4,5,6,7-tetrabromo-1H-benzotriazole and 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole) and gene knockdown using RNA interference, we identified CK2, a kinase responsible for myosin-9 phosphorylation at Ser1943, as a key factor contributing to the radiation-induced senescence of hMSC. We showed that individual knockdown of CK2 catalytic subunits CK2α and CK2α′ induced hMSC senescence. However, only knockdown of CK2α resulted in morphologic phenotypes resembling those of radiation-induced senescence. These results suggest that CK2α and CK2α′ play differential roles in hMSC senescence progression, and their relative expression might represent a novel regulatory mechanism for CK2 activity. [Cancer Res 2009;69(20):8200–7]
Bacteroides Infection among Hospital Patients
Authors: O. A. Okubadejo, P. J. Green, D. J. H. Payne
Journal: BMJ (1973)

In an 18-month period a total of 118 isolates of Bacteroides species, mainly Bacteroides fragilis, were grown from 112 hospital patients with various conditions. The infections were severe and were associated with serious operations such as intestinal surgery for carcinoma and postpartum hysterectomy. Blood cultures were often found to be positive too late in the course of infection for prompt and successful antibiotic therapy to be given. All the Bacteroides species tested were sensitive to clindamycin and co-trimoxazole. We suggest that clindamycin should be added to an empirical antibiotic regimen for the treatment of patients prone to the infection.
Does autonomic dysfunction play a role in atopic dermatitis?
Authors: D. Cicek, B. Kandi, M.S. Berilgen, S. Bulut, A. Tekatas, S.B. Dertlioglu, S. Ozel, Y. Saral
Journal: British Journal of Dermatology (2008)

Atopic dermatitis (AD) is a chronic dermatitis characterized by intense itching and excessive skin dryness. The factor most commonly blamed for the pathogenesis of skin dryness in the disease is impaired barrier function of the stratum corneum. However, there are findings indicating that the autonomic nervous system, and the sympathetic nervous system in particular, is affected negatively in AD, and thus, autonomic dysfunction can be an important factor leading to skin dryness.In this study we aimed to evaluate the functioning of the autonomic nervous system electrophysiologically using R-R interval variation (RRIV) and the sympathetic skin response (SSR) in patients with AD, and to examine whether there is an underlying autonomic nervous system dysfunction.The study registered a total of 38 (12 males and 26 females) patients with AD, of whom 24 had active and 14 inactive disease, and 20 (10 males and 10 females) healthy control subjects. RRIV was used in our study as the electrophysiological test to evaluate the parasympathetic system. The SSR method, which is a noninvasive electrophysiological test with a significant role in evaluating the sudomotor activity of skin, as well as that of the unmyelinated fibres that take a part in this activity, was employed to assess the sympathetic nervous system.Our study revealed a significantly prolonged SSR latency and amplitude of the upper extremity in the patient group, relative to the control group (P < 0.05). When the group with active skin lesions was compared with the control group, the former was found to have prolonged SSR latency and amplitude in the upper extremity. The prolongation in SSR latency of the upper extremity was statistically significant (P < 0.05), while the prolongation in amplitude was not (P = 0.5). An evaluation of RRIV results did not show a significant difference between the patient and control groups.These findings demonstrate that the sudomotor activity controlled by the sympathetic nervous system, as well as unmyelinated fibres that play a role in this activity are affected in patients with AD. We think that the involvement of sudomotor activity may be one of the causes that leads to dysfunction in sweat glands and skin dryness.
Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells
Authors: Michael G. Strainic, Jinbo Liu, Danping Huang, Fengqi An, Peter N. Lalli, Nasima Muqim, Virginia S. Shapiro, George R. Dubyak, Peter S. Heeger, M. Edward Medof
Journal: Immunity (2008)