tbuckley/cabot-search huggingface dataset:
Budesonide and terbutaline or terbutaline alone in children with mild asthma: effects on bronchial hyperresponsiveness and diurnal variation in peak flow.
Authors: H J Waalkens, J Gerritsen, G H Koeter, F H Krouwels, W M van Aalderen, K Knol
Journal: Thorax (1991)

The effects of treatment with budesonide (200 micrograms twice daily) and terbutaline (500 micrograms four times daily) has been compared with the effects of placebo and terbutaline in 27 children with mild asthma, aged 7-14 years, in a double blind, randomised placebo controlled study over eight weeks. Bronchial responsiveness (PC20 histamine), lung function, the amplitude of diurnal variation in peak expiratory flow (PEF), and symptom scores were measured. Baseline FEV1 was over 70% predicted and PC20 histamine less than 8 mg/ml. Twelve children were treated with budesonide and terbutaline and 15 with placebo and terbutaline. After four and eight weeks of treatment the change in PC20 was significantly greater after budesonide and terbutaline than after terbutaline alone by 2.1 (95% CI 0.5-3.8) and 1.3 (95% CI 0.1-2.5) doubling doses respectively. Mean FEV1 did not change in either group. The change in afternoon and nocturnal PEF was significantly greater after budesonide and terbutaline than after terbutaline alone. The amplitude of diurnal variation in PEF did not change significantly in either group. Peak flow reversibility decreased in the budesonide group. There were no differences between treatments for cough and dyspnoea, but wheeze improved in the budesonide group. The children with mild asthma treated with budesonide and terbutaline showed improvement in bronchial responsiveness, afternoon and nocturnal PEF, and symptoms of wheeze and a fall in peak flow reversibility by comparison with those who received terbutaline alone.
Safety and Efficacy of First-Line Bevacizumab Plus Chemotherapy in Elderly Patients with Advanced or Recurrent Nonsquamous Non-small Cell Lung Cancer: Safety of Avastin in Lung trial (MO19390)
Authors: Janessa Laskin, Lucio Crinò, Enriqueta Felip, Fabio Franke, Vera Gorbunova, Harry Groen, Guo-liang Jiang, Martin Reck, Claus-Peter Schneider
Journal: Journal of Thoracic Oncology (2011)
DERMANYSSUS AND LIPONYSSUS AVIUM ET GALLINM ATTACKING MAN
Authors: R. H. BOYT
Journal: British Journal of Dermatology (1937)

Journal Article DERMANYSSUS AND LIPONYSSUS AVIUM ET GALLINM ATTACKING MAN Get access R. H. BOYT, M.B., B.S.Melb R. H. BOYT, M.B., B.S.Melb Clinical Assistant to Dermatologist, Royal Melbourne Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 49, Issue 2, 1 February 1937, Pages 66–68, https://doi.org/10.1111/j.1365-2133.1937.tb11153.x Published: 01 February 1937
Comparative adherence of granulocytes to endothelial monolayers and nylon fiber.
Authors: R R MacGregor, E J Macarak, N A Kefalides
Journal: Journal of Clinical Investigation (1978)

Adherence of granulocytes to tissue culture monolayers of endothelium averaged 26.2 +/- 1.3% SEM, which was similar to their adherence on 50-mg nylon fiber columns (27.7 +/- 3.6%). In contrast, adherence to epithelial cells, fibroblasts, kidney cells, and plastic Petri dishes without monolayers was only 12.4, 9.9, 11.1, and 4.3%, respectively. Cyclic nucleotides and adherence-modifying plasma factors induced changes of adherence to endothelium similar to those in nylon fiber columns. Adherence of granulocytes in whole blood was the same as for purified granulocytes in Hank's balanced salt solution. Exposure of endothelial monolayers to 0.18% trypsin for 10 min reduced subsequent granulocyte adherence to 25.2% of control values. Incubation of trypsin-treated monolayers with nutrient medium for 4 h did not improve adherence, but values returned to normal or above by 24 h, with or without serum proteins present in the nutrient medium. The similarity of granulocyte adherence to nylon fiber and to endothelial monolayers in vitro suggests that results with the nylon fiber assay reflect in vivo granulocyte-endothelium interaction. Furthermore, the endothelial monolayer offers a new model for studying this cell-cell relationship in vitro.
Properties and applications of pyrethroids.
Authors: M Elliott
Journal: Environmental Health Perspectives (1976)

Improved understanding of the factors determining the insecticidal activity, the mammalian toxicity, and the stability in air and light of natural and synthetic pyrethroids has led to a series of new compounds with a very favorable combination of properties. Their characteristics include outstanding potency to insects, low toxicity to mammals associated with rapid metabolic breakdown and, in appropriate cases, adequate stability on plant surfaces even in bright sunlight. Initial tests indicate that even the more stable compounds are degraded rapidly in soil, so if the trials at present in progress reveal no toxicological or environmental hazards, within a few years synthetic pyrethroids should be available to control a wide range of domestic, veterinary, horticultural, agricultural, and forest pests at low rates of application.
Dietary Fiber Intake Modulates the Association Between Variants in <i>TCF7L2 </i> and Weight Loss During a Lifestyle Intervention
Authors: Martin Heni, Silke Herzberg-Schäfer, Fausto Machicao, Hans-Ulrich Häring, Andreas Fritsche
Journal: Diabetes Care (2012)

Single nucleotide polymorphisms (SNPs) within the transcription factor 7-like 2 ( TCF7L2 ) gene are well known risk variants for type 2 diabetes (1). The best studied SNP is rs7903146, which is additionally associated with insulin secretion (2) and BMI (3). We furthermore reported that this variant influenced weight loss during the Tubingen Lifestyle Intervention Program (TULIP) such that carriers of the nonrisk CC alleles lost more weight than carriers of XT alleles (4). The TULIP program consists of exercise and diet intervention with decreased intake of fat and increased intake of fibers (participants were instructed to eat at least 15 g fiber per 1,000 kcal). However, a recent report (1) from the Diabetes Prevention Program (DPP) failed to replicate the association of TCF7L2 SNP rs7903146 with successful weight loss during lifestyle intervention. The authors speculated that …
American Medical Education: The Formative Years, 1765-1910
Authors: Lester S. King
Journal: JAMA (1976)

Kaufman has performed a highly useful task in providing us with a perspective on medical education during the "formative" years. He has covered much relevant material—journal articles, reports, proceedings, correspondence, biographies, archival data, as well as important secondary sources—to indicate the education of physicians and the practice of medicine in times past. His picture is indeed a depressing one. Perhaps other historians might have painted a picture in somewhat brighter colors. The establishment of the first medical schools in the latter 18th century offered great promise which, unfortunately, was not fulfilled by the subsequent course of events. Standards of practice and education declined. Various sects competed with "regular" medical practice. Kaufman describes the various attempts at reform, which had only nominal success. He emphasizes the low standards and the ineffective efforts on the part of a few educators to improve the situation. The establishment of the Johns Hopkins University seemed
Education in the Sciences
Authors: Joseph A. Gengerelli
Journal: JAMA (1965)

The edifice of scientific knowledge has often been likened to an inverted pyramid: at the point of the pyramid is found that domain of knowledge which is self-contained in the sense that its contents and structure depend on nothing else. Here is to be found pure mathematics, as exemplified in analysis, the theory of sets, topology, mathematical logic, and so on. As we move upward in the pyramid, the area of knowledge widens but is supported by what lies below it. Here we find the inanimate sciences: physics and chemistry, with all their rich ramifications, pure and applied. What is described by Newton's laws or by Maxwell's equations, for example, is not found in the domain of pure mathematics, but it is clear that without mathematics these creations of scientific genius would never have seen the light of day.  In the next stratum of the pyramid we find the life
Technical Difficulties and Evaluating e-Health Interventions—Reply
Authors: Aarti Kakkar, Brian C. Jacobson
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Control of IgE and selective TH1 and TH2 cytokines by PG102 isolated from Actinidia arguta
Authors: Eun-Jin Park, Bongcheol Kim, Haekwan Eo, Kyungcheol Park, Yeonran Kim, Hwa Jun Lee, Miwon Son, Yoon-Seok Chang, Sang-Heon Cho, Sunyoung Kim, Mirim Jin
Journal: Journal of Allergy and Clinical Immunology (2005)
Anatomy Lab, Day Ten
Authors: Benjamin Perin
Journal: Annals of Internal Medicine (2013)

Ad Libitum2 April 2013Anatomy Lab, Day TenBenjamin Perin, BABenjamin Perin, BAFrom Seattle, Washington.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-7-201304020-00022 Audio Reading - “Anatomy Lab, Day Ten” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Anatomy Lab, Day Ten," by B. Perin. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Today we dissected the middle ear.I'm not much for intelligent design but the ear'san open invitation to stop and wonder.It was easy to see evolution's muddy footprints in the thorax,what with the recurrent laryngeal nerve caught up around the aortalike a loose wirethe sheer asymmetry of it all.Sketches fill slate chalkboards in a classroom somewhere of ... Author, Article, and Disclosure InformationAuthors: Benjamin Perin, BAAffiliations: From Seattle, Washington.Current Author Address: Benjamin Perin, BA; University of Washington School of Medicine, 4830 36th Avenue NE, Seattle, WA 98105; e-mail, bip2@u.washington.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Anatomy Lab, Day Ten” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Anatomy Lab, Day Ten," by B. Perin. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 2 April 2013Volume 158, Issue 7Page: 572KeywordsAortaBoneMusclesNervesThorax ePublished: 2 April 2013 Issue Published: 2 April 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Current practice with endoscopic submucosal dissection in Europe: position statement from a panel of experts
Authors: P. Deprez, J. Bergman, S. Meisner, T. Ponchon, A. Repici, M. Dinis-Ribeiro, J. Haringsma
Journal: Endoscopy (2010)

Endoscopic submucosal dissection (ESD) is the gold standard technique for performing en bloc resection of large superficial tumors in the upper and lower gastrointestinal tract. Experience in Europe, however, is still limited and ESD is only performed in a few selected centers, with low volumes of cases, no description of training programs, and few published reports. In 2008, a panel of experts gathered in Rotterdam to discuss indications, training, and the wider use of ESD. The panel of experts and participants reached a consensus on five general statements: 1) ESD aims at treating mucosal cancer; 2) treatment aims for R0 resection; 3) ESD should meet quality standards; 4) ESD should be performed following national or European Society of Gastrointestinal Endoscopy (ESGE) guidelines or under institutional review board approval; and 5) ESD cases should be registered. Due to the high level of expertise needed to perform the technique safely, ESD should be performed in a step-up approach, starting with lesions presenting in the rectum or in the distal stomach, then colon, proximal stomach, and finally in the esophagus. Registration is advised either at the local site or at a national or ESGE level, and should include information on indication (Paris classification of lesion, location, and histological results prior to treatment), technique used (e. g. type of knife), results (en bloc and R0 resection), complications, and follow-up. The panel also agreed on minimal institutional requirements: good quality imaging, experienced histopathologist following the Japanese criteria (2-mm sections, micrometric invasion, vessel and lymphatic infiltration, etc), and dedicated endoscopic follow-up. Moreover, minimum training requirements were also defined: knowledge in indications and instruments, exposure to experts (currently all in Japan), hands-on experience in a model of isolated pig stomach and in live pigs, and management of complications. The experts did not reach a consensus on a minimum case load, or whether the technique should be restricted to expert centers.
DIET IN THE CHRONIC CATARRHS OF THE GASTRO-INTESTINAL TRACT.
Authors: BOARDMAN REED
Journal: JAMA (1898)

In treating of diet in the chronic catarrhal inflammations of the stomach and intestines it is not intended to limit the discussion to those cases only which are usually classed as such. Our present exact methods show that chronic gastric catarrh in its earlier stages is rarely accompanied by nausea or vomiting and not always by pain in the stomach itself; also that cases of gastritis grave enough to have seriously impaired the health may be characterized by an increase rather than by a diminution of the appetite. Again the same methods prove the frequent coexistence of catarrhal disease in the small intestines and persistent constipation or constipation alternating with diarrhea when the disease has become more advanced. Obstinate chronic diarrhea points usually to an aggravated catarrhal inflammation of the intestinal mucous membrane complicated in many cases with ulceration. A proper regulation of the diet is important in most derangements
5′ nucleotidase in chronic b cell leukemias: A cytochemical and ultrastructural study
Authors: Rosangela Invernizzi, Pasqualina de Fazio, Carla Fenoglio, Giovanbattista Ippoliti, Luisa M. Zambelli, Monica Razzano, Edoardo Ascari
Journal: American Journal of Hematology (1990)

We studied by cytochemical means the distribution of 5' nucleotidase (5' NT), a purine degradative enzyme, in the circulating lymphocytes of 24 healthy donors and 41 cases of chronic lymphoid leukemias, classified according to morphological and immunological criteria. About half the normal circulating lymphocytes were 5'NT positive and exhibited variable degrees of enzyme activity. Among chronic B lymphocytic leukemias we found high percentages of positive cells only in the phenotypically more mature cases. Moreover all cases of hairy cell, follicular cell, lymphoplasmacytic, and plasma cell leukemia showed moderate or weak 5' NT reactivity. Also one case of chronic T lymphocytic leukemia, CD8 positive, was moderately positive, while another, with large granular lymphocyte morphology, was completely negative. Electron microscopy revealed a discontinuous, granular plasma membrane reaction pattern, varying in intensity from case to case. In conclusion, our results confirm the usefulness of the 5' NT cytochemical reaction for identification of lymphoid populations at different stages of maturation in chronic B cell disorders.
Endothelial Progenitor Cell Vascular Endothelial Growth Factor Gene Transfer for Vascular Regeneration
Authors: Hideki Iwaguro, Jun-ichi Yamaguchi, Christoph Kalka, Satoshi Murasawa, Haruchika Masuda, Shin-ichiro Hayashi, Marcy Silver, Tong Li, Jeffrey M. Isner, Takayuki Asahara
Journal: Circulation (2002)

Previous studies have established that bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation. In the current study, we investigated the hypothesis that gene transfer can be used to achieve phenotypic modulation of EPCs.In vitro, ex vivo murine vascular endothelial growth factor (VEGF) 164 gene transfer augmented EPC proliferative activity and enhanced adhesion and incorporation of EPCs into quiescent as well as activated endothelial cell monolayers. To determine if such phenotypic modulation may facilitate therapeutic neovascularization, heterologous EPCs transduced with adenovirus encoding VEGF were administered to athymic nude mice with hindlimb ischemia; neovascularization and blood flow recovery were both improved, and limb necrosis/autoamputation were reduced by 63.7% in comparison with control animals. The dose of EPCs used for the in vivo experiments was 30 times less than that required in previous trials of EPC transplantation to improve ischemic limb salvage. Necropsy analysis of animals that received DiI-labeled VEGF-transduced EPCs confirmed that enhanced EPC incorporation demonstrated in vitro contributed to in vivo neovascularization as well.In vitro, VEGF EPC gene transfer enhances EPC proliferation, adhesion, and incorporation into endothelial cell monolayers. In vivo, gene-modified EPCs facilitate the strategy of cell transplantation to augment naturally impaired neovascularization in an animal model of experimentally induced limb ischemia.
Fads in the Treatment of Low Back Pain
Authors: Richard A. Deyo
Journal: New England Journal of Medicine (1991)

The history of medical care for low back pain —one of the most common causes of morbidity and absenteeism in the United States — involves serial fashions in diagnosis and therapy. Earlier in this century, sacroiliac joint disease was thought to account for many cases of back pain, and this led to many fusions of the sacroiliac joint.1 Coccydynia was a popular diagnosis that led to a wave of coccygectomies, a procedure now almost completely abandoned.2 The use of chymopapain injections for herniated lumbar intervertebral disks enjoyed explosive growth in the early 1980s, but has declined greatly. Recent clinical trials . . .
Recovery Fund Grants
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe Injection Site Reaction to Insulin Detemir
Authors: Ian R. Blumer
Journal: Diabetes Care (2006)

Insulin detemir is a new long-acting insulin analog. Though generally well tolerated, injection site reactions have been reported in 2% of insulin detemir users (1). Most commonly, these untoward reactions manifest as mild injection site erythema or discomfort and seldom lead to discontinuation of the product. Herein, I report the case of a patient with a severe local reaction to insulin detemir necessitating its withdrawl.

A 37-year-old Caucasian woman with a 25-year history of type 1 diabetes was switched from NPH (Humulin …
Accident and emergency in London. Good primary care reduces workload.
Authors: D J Harborne, J Worrell
Journal: BMJ (1993)

general practitioner in the accident and emergency department can provide the necessary care for these patients.Where this has occurred the results have been promising.This response to public expectation in the accident and emergency department will not, however, improve the perception of what treatment the general practi- tioner based in the community can provide for non-urgent problems.
Paediatric Orthopaedics and Fractures
Authors: G. Dean MacEwen
Journal: JAMA (1972)

In the field of orthopedics there has been a deficiency of suitable texts in children's orthopedics. This book helps to meet the deficiency. It reads easily, as is so characteristic of United Kingdom texts; it is well illustrated, and covers essentially all of the problems encountered in children's orthopedics. At times, the treatment program suggested is not as exact as we might expect. On pages 196 to 198 a trifin nail is suggested as a possible method of treatment of slipped capital femoral epiphysis, with the statement that the nail should be centered in the femoral head. This is not accomplished in either the anterioposterior or lateral view of the roentgenographic illustrations. The discussion of sepsis of the hip suggests that if aspiration is difficult, arthrotomy may be advisable to release and remove the pus: a strong recommendation for surgery in such an important decision would seem to be warranted.