tbuckley/cabot-search huggingface dataset:
Modified Shuffled Blo t 5 Recombinant Allergen From Blomia Tropicalis Produces a Shift Of Antigenicity For Binding To IgG4 Isotype
Authors: Ernesto Taketomi, Bárbara Ávila, Karine Almeida, Deise Silva, Odonírio Abrahão Júnior, Jair Cunha-Júnior
Journal: Journal of Allergy and Clinical Immunology (2014)
Hypophosphatasia and Congenital Bowing of the Long Bones
Authors: David C. Kellsey
Journal: JAMA (1962)

Hypophosphatasia, manifested in the bowing and shortening of both femora and a tibia, was noted at birth in a female infant. At 4 1/2 months the infant suddenly became extremely irritable and ceased to thrive. The diagnosis was established by chemical studies which revealed extremely low levels of alkaline phosphatase in the serum and large amounts of phosphoethanolamine in the urine. A fall, though the associated trauma was otherwise minimal, resulted in a fracture of the right femur, and the prognosis is poor.
VALPROATE ATTENUATES THE RISK OF MYOCARDIAL INFARCTION IN PATIENTS WITH EPILEPSY: A NATIONWIDE COHORT STUDY
Authors: Jonas B. Olesen, Peter R. Hansen, Steen Z. Abildstrøm, Charlotte Andersson, Peter Weeke, Michelle Schmiegelow, Jesper Erdal, Christian Torp-Pedersen, Gunnar H. Gislason
Journal: Journal of the American College of Cardiology (2010)
IS RADIAL APPROACH BETTER THAN FEMORAL ONE DURING PRIMARY CORONARY ANGIOPLASTY? INSIGHTS FROM PAPRICA-OUTCOMES DATABASE PARMA PRIMARY CORONARY ANGIOPLASTY
Authors: Emilia Solinas, Luigi Vignali, Alberto Menozzi, Maria Alberta Cattabiani, Iacopo Tadonio, Diego Ardissino
Journal: Journal of the American College of Cardiology (2011)
Abnormal Parathyroid Scan (Thallium-Technetium Mismatch) with Benign and Malignant Thyroid Nodules in the Same Patient
Authors: P VELUVOLU, ARTHUR Z. KRASNOW, RICHARD E. RODGERS, B DAVID COLLIER, ALI T. ISITMAN, ARNOLD J. KRUBSACK, SHEKHAR THAKUR
Journal: Clinical Nuclear Medicine (1991)

A parathyroid scan was performed in a patient with pathologic diagnosis of follicular adenoma of the right lobe, follicular carcinoma of isthmus, and intrathyroidal left superior parathyroid adenoma. Thallium-technetium mismatch is seen in the region of the follicular adenoma and follicular carcinoma.
Compression of median nerve at elbow.
Authors: M J Kelly, B T Jackson
Journal: BMJ (1976)

Compression of median nerve at elbowCompression of the median nerve at the wrist causing carpal tunnel syndrome is an entrapment neuropathy known to every final year medical student.What is not so well known, however, is that com- pression of the median nerve may occur in the region of the elbow and simulate the clinical features of carpal tunnel syndrome. Case reportA 46-year-old man was admitted to St Helier Hospital, Carshalton, for treatment of primary hypercholesterolaemia.He was observed to have considerable wasting of the muscles of the left thenar eminence and probable wasting of the left forearm.On direct questioning he admitted that he had had some weakness of the left hand for several years but denied sensory symptoms.Neurological examination showed gross weakness of the left thumb with wasting of abductor pollicis brevis, flexor pollicis brevis, and possibly flexor carpi radialis.Perception of sharp and blunt in the pulp of the left index finger was diminished, but sensation in the hand was otherwise normal.There were no localised areas of tenderness in the arm or hand.Investigations included normal radiographs of the chest, elbows, and cervical spine.No supracondylar spurs were present.Electromyography suggested compression of the median nerve at the level of the elbow and it was decided to explore this region.
Residual Shunt After Ductus Arteriosus Occluder Implantation Complicated by Late Endocarditis
Authors: Christophe Saint-André, Xavier Iriart, Hopewell Ntsinjana, Jean-Benoît Thambo
Journal: Circulation (2012)

report the case of a 20-year-old woman who had percutaneous closure of a patent ductus arteriosus (PDA) with a 17-mm Rashkind occluder when she was 4 years of age.A small residual shunt was noted on color-flow Doppler echocardiography immediately after the procedure and at 6-month follow-up.Because of the lack of hemodynamic complications, no additional intervention was performed.Sixteen years later, she presented with recurrent bilateral bronchopneumonia that required antibiotic treatment.Chest radiography during the third episode showed a right bronchopneumonia (Figure 1).At that time, new treatment with amoxicillin and clavulanic acid was given for 10 days, but fever persisted despite this course of antibiotics.Results of the physical examination showed blood pressure of 110/70 mm Hg, pulse of 92 bpm, temperature of
Film: 28 Days
Authors: C. Brewer
Journal: BMJ (2000)

Directed by Betty Thomas, Columbia Pictures

On worldwide general release

Twenty eight days is apparently how long you normally stay if—after getting disgustingly drunk and wrecking your sister's wedding, not to mention the nuptial limousine—you reluctantly enter an American “rehabilitation” clinic. Rehabilitation is big business in the United States, and remarkably monolithic.

28 Days gives a reasonably accurate impression of life in a typical private rehabilitation facility and of some of its highs and lows. The highs include heart warming insights of the “I guess I never saw it that way” variety and the support and experience of other addicts. But, although you may feel uplifted by some of your fellow sufferers, the film also shows how others can depress you, offer you dope, or involve you in damaging relationships when you're feeling lonely and vulnerable.

Like most US rehabilitation programmes, the one in the film is based on the “twelve steps,” advocated by Alcoholics Anonymous. Eclectic it isn't, and no other approach gets a look in. While it is undoubtedly important to accept that you have a problem, being on a “twelve steps” programme means having to get up in a group and say things like, “Hello, my name's Cheryl, and I'm an alcoholic.” This, of course, can be adapted to “I'm a heroin/cocaine/gambling/shopping/sex/soap opera addict” (delete as necessary). The film suggests that US rehabilitation involves lots of hugs, tears, group chants, and saccharine effusions of Panglossian optimism. This is not everyone's cup of tea. Medication is banned even for nasty withdrawal symptoms or a badly sprained ankle from jumping out of a window to retrieve some smuggled narcotics. 

Unfortunately for the plot, subtlety and irony are also prohibited substances. The drunken, good time heroine, played by Sandra Bullock, sees the light, helped apparently by a horse who doubles as a therapist (I don't think I was hallucinating this bit). She eventually does the right thing with her ghastly drunken boyfriend, who is, incidentally, English. There were few people in the cinema at the start and even fewer by the end. Maybe it plays better in Los Angeles or Pensacola. Call us a tight arsed nation, but, despite the emergence of a few home grown Oprah Winfreys, the confessional culture doesn't seem to do too well here. As the writer Alan Bennett confided to his diary after he was taken to an Alcoholics Anonymous meeting in New York, “I felt like getting up and saying, ‘Hello my name’s Alan and I'm English and we don't do this sort of thing.'”
Myoglobin content in human skeletal muscle and myocardium: relation to fibre size and oxidative capacity
Authors: C. SYLVEN, E. JANSSON, K. BOOK
Journal: Cardiovascular Research (1984)

Myoglobin, muscle fibre diameter, and citrate synthase activity were measured in leg muscle of untrained and trained men and in the myocardium from the apex of the left ventricle and from papillary muscle in patients subjected to open heart surgery. The citrate synthase (CS) activity was 60% higher in trained than in untrained skeletal muscle. In the myocardium it was around four times greater than in untrained skeletal muscle but there was no difference between the apex of the left ventricle and papillary muscle. The fibre diameter varied almost threefold between the different groups of muscles with the largest diameter in untrained skeletal muscle and the smallest in papillary muscle. The myoglobin content in trained skeletal muscle did not differ from that of untrained muscle. In the left ventricle it was only 40% of that found in untrained muscle while papillary muscle had almost twice as high a myoglobin content as did the left ventricle. The ratio between myoglobin and fibre diameter, however, was of similar magnitude in skeletal muscle and the left ventricle while it was twice as high in papillary muscle as in the other muscles. In conclusion, the diffusion distance in terms of fibre diameter decreased with increased oxidative capacity (CS activity), when comparing the statistical means of the four different groups. The capacity for oxygen diffusion in relation to oxygen demand measured as the ratio of myoglobin to fibre diameter appeared to be of a similar magnitude in skeletal muscle and left ventricle but was higher in papillary muscle.
Low Filaggrin Monomer Repeats in African American Pediatric Patients With Moderate to Severe Atopic Dermatitis
Authors: Ashley M. Quiggle, Zane A. Goodwin, Twinkal R. Marfatia, Monique G. Kumar, Heather Ciliberto, Susan J. Bayliss, Cristina de Guzman Strong
Journal: JAMA Dermatology (2015)

The severity of atopic dermatitis (AD) and intragenic filaggrin (FLG; OMIM 135940) copy number variant (CNV) genotypes were assessed in African American pediatric patients, a health disparities group that is disproportionately affected with AD.1
Scurvy Simulating Gastric Neoplasm
Authors: K. Dewhurst
Journal: BMJ (1954)

Field TrialForty-seven boys and girls aged between 5 and 12 years completed all the tests.They had never rec-eived any artificial diphtheritic antigens before.They had been living in crowded houses in not quite hygienic surroundings.Just before their first Schick test a sample of blood was drawn.The second sample of blood was drawn and the second Schick test was done two weeks after the first Schick test.The results are shown in Table I.TABLE I.-Response of Naturally Immunized Indian Children to the Stimulus of Schick Toxin Rise 2 Weeks after the Preliminary ImmunityFisScckTt No. of
Not Sold on Performance Measures
Authors: Bruce E. Landon, Sharon-Lise T. Normand
Journal: Annals of Internal Medicine (2008)

Letters15 July 2008Not Sold on Performance MeasuresBruce E. Landon, MD, MBA and Sharon-Lise T. Normand, PhDBruce E. Landon, MD, MBAFrom Harvard Medical School, Boston, MA 02115.Search for more papers by this author and Sharon-Lise T. Normand, PhDFrom Harvard Medical School, Boston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-2-200807150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We sympathize with the sentiments expressed by Dr. Miller. One of us is a practicing physician and is aware of the extra burden imposed by many performance measurement programs with unclear patient benefits. Evidence suggests, however, that the proliferation, measurement, and dissemination of quality information have a substantial impact on measured areas of quality. Indeed, one measure (β-blocker use after a myocardial infarction) has been retired because performance has approached perfection (1). It is highly unlikely that performance on this measure and others would be so high if a spotlight had not been aimed at them. Although pay-for-performance ...References1. Lee TH. Eulogy for a quality measure. N Engl J Med. 2007;357:1175-7. [PMID: 17881749] CrossrefMedlineGoogle Scholar2. Kohn KT, Corrigan JM, Donaldson MS, eds. Institute of Medicine. To Err Is Human: Building a Safer Health System. Washington, DC: National Academies Pr; 1999. Google Scholar3. Institute of Medicine. Crossing the Quality Chasm: A New Health System for the 21st Century. Washington, DC: National Academies Pr; 2001. Google Scholar4. McGlynn EA, Asch SM, Adams J, Keesey J, Hicks J, DeCristofaro A, et al. The quality of health care delivered to adults in the United States. N Engl J Med. 2003;348:2635-45. [PMID: 12826639] CrossrefMedlineGoogle Scholar5. Landon BE, Normand SL, Blumenthal D, Daley J. Physician clinical performance assessment: prospects and barriers. JAMA. 2003;290:1183-9. [PMID: 12953001] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Harvard Medical School, Boston, MA 02115.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPerformance Measurement in the Small Office Practice: Challenges and Potential Solutions Bruce E. Landon and Sharon-Lise T. Normand Not Sold on Performance Measures Michael E. Miller Metrics 15 July 2008Volume 149, Issue 2Page: 146-147KeywordsConflicts of interestElectronic medical recordsHealth careHealth care qualityHealth care utilizationMyocardial infarction ePublished: 15 July 2008 Issue Published: 15 July 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Defective Nerve-Power as a Primary Cause of Disease, with its Special Relation to Dipsomania
Authors: S. S. Alford
Journal: BMJ (1881)

THE BRITISh MEDICAL _OURNAL. 591.~~~~~~~~~~~9 gains nearly its normal standard.Sometimes this improvement is per- manent, but often the anoemia returns at some later date, under the influence of some exciting cause.There is an anaemic tendency in such
THE COLUMBIA TISSUE AND INTESTINAL FORCEPS.
Authors: I. S. STONE
Journal: JAMA (1905)

The accompanying cut shows a most satisfactory pair of forceps for general and special surgical work. They have been used at the Columbia Hospital for many years and have heretofore been made to order by instrument makers, but do not appear in any instrument catalogue nor have they ever been described, as far as I know. These forceps are valuable in pelvic work, especially in intestinal surgery, as they will not easily puncture the intestine as will rat-tooth forceps. In fact, they are like the delicate finger touch which permits handling without injury. The arms open widely above the teeth, allowing plenty of space for grasping sponges or larger portions of muscle or fat, or the handling of any organ within the abdomen. They are six inches in length, but longer forceps can be made as ordered. <h3>Apocynum Cannabinum.</h3> —In malarial conditions with torpid liver, in jaundice, in all cases
Successful treatment of adult T‐cell leukemia with unrelated cord blood transplantation
Authors: Jun Takizawa, Sadao Aoki, Tori Kurasaki, Masutaka Higashimura, Keiichiro Honma, Toshiki Kitajima, Akihito Momoi, Hidenobu Takahashi, Naoya Nakamura, Tatsuo Furukawa, Yoshifusa Aizawa
Journal: American Journal of Hematology (2007)

This study reports the first well-documented case of adult T-cell leukemia (ATL) successfully treated with unrelated cord blood transplantation (UCBT). A 49-year-old woman was diagnosed with acute-type of ATL. Chemotherapy induced complete remission, but the human T-cell leukemia virus type 1 (HTLV-1) proviral load was detected in mononuclear cells of her peripheral blood. The patient received UCBT with a conditioning regimen consisting of total body irradiation, cytarabine, and cyclophosphamide. She remains in remission 30 months after UCBT and the HTLV-1 proviral load has fallen to undetectable levels. This result suggests that UCBT should be a therapeutic option for ATL patients who do not have suitable donors and those who urgently require treatment.
Consensus for treatment of 'the sickest patients you'll ever see'
Authors: B. J. Montgomery
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1095 DEMONSTRATION OF AN HEPATOCYTE CANALICULAR LOCALIZATION OF CYP2D6, THE TARGET OF LIVER KIDNEY MICROSOME TYPE 1 AUTOANTIBODIES, MARKERS OF TYPE 2 AUTOIMMUNE HEPATITIS
Authors: E. Beleoken, F. El Rabaa, B. Grosse, M.Z. Mustafa, D. Samuel, C. Johanet, D. Cassio, J.-C. Duclos-Vallee, E. Ballot
Journal: Journal of Hepatology (2010)
Abstract 1176: Tumor derived peptide from a2 isoform of Vacuolar ATPase immunomodulates tumor associated neutrophils
Authors: Safaa A. Ibrahim, Magdy Amin, kenneth D. Beaman
Journal: Cancer Research (2014)

Abstract It has been recently discovered that tumor associated neutrophils (TAN) develop N2 polarization similar to tumor associated macrophages (TAM). It is believed that the tumor microenvironment can provoke the wound repair response from TAN and TAM which in turn promotes tumor progression. Transforming growth factor- β (TGF-β) plays a key role in N2 polarization, however, other regulatory mechanisms are still unclear. a2 isoform Vacuolar ATPase (a2V) are highly expressed on tumors and macrophages. Recent evidence showed that a cleaved peptide from the N-terminal domain of a2V (a2NTD) is secreted in the microvesicles collected from various tumor cell lines. This peptide promotes the pro-tumorigenic characteristics in macrophages. Moreover, priming neutrophils with tumor conditioned media (TCM) collected from breast cancer cell lines promotes the pro-tumorigenic properties in neutrophils. In this study, we are evaluating the in vitro immune-modulatory effect of a2NTD on polymorphnuclear leukocytes (PMN) in order to explore the role of the a2V in the sterile inflammation associated with tumor progression. We isolated PMN from heparin anti-coagulated blood collected from healthy adult volunteers. TCM were collected from MDA-MB-231 breast cancer cell line. PMN were stimulated with either recombinant a2NTD or with TCM to simulate the tumor microenvironment. In both a2NTD and TCM cultures, distinctive morphological changes were revealed by microscopical examination and significant elevation of ROS levels were detected by flow cytometry (p-value &amp;lt;0.05). Moreover, we have observed an upregulation in PMN gene expression of CCL2, CXCL-1, CXCL-2, TNFα, VEGF, MMP-9, neutrophil elastase as well as a2V when it is cultured with either a2NTD or TCM using quantitative real time PCR. In accordance with Queen M., et al, flow cytometry showed delayed PMN apoptosis in cultures with TCM while upon inhibiting V-ATPase, PMN survival decreased significantly (p-value &amp;lt;0.05).This suggests that the delayed apoptosis observed in TCM primed PMN is mediated at least partially by V-ATPase. In addition, a2NTD increased significantly the PMN survival but to a lesser extent compared with TCM. Interestingly, we observed significant surface over-expression of a2V on PMN in both cultures using flow cytometry (p-value &amp;lt;0.05) and confocal microscopy. Our study demonstrates the potential immune-modulatory effect of tumor associated a2NTD on PMN which may indicate its involvement in tumor progression. Citation Format: Safaa A. Ibrahim, Magdy Amin, kenneth D. Beaman. Tumor derived peptide from a2 isoform of Vacuolar ATPase immunomodulates tumor associated neutrophils. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1176. doi:10.1158/1538-7445.AM2014-1176
Understanding America's Drinking Problem: How to Combat the Hazards of Alcohol
Authors: Donald W. Goodwin
Journal: JAMA (1988)

Don Cahalan, professor emeritus at Berkeley, is one of the country's leading authorities on alcoholism. This book gives a welcome opportunity to see what he thinks about the alcohol scene today. What he thinks is not reassuring. Despite millions of dollars spent on alcoholism treatment, there are more alcoholics than ever (he says). Treatments for alcoholism are not very good, if they work at all. Governmental antidrinking efforts are fragmented and ineffective. One percent of research funds goes for alcoholism—not enough. The alcohol industry successfully lobbies against every attempt to reduce drinking, such as raising taxes or putting warning labels on bottles. Instead, industry tries to increase consumption, through advertising, by presenting a potentially lethal drug as a kind of glamorous 7-Up. True, the situation is not all bleak. Despite the greedy alcohol merchants and docile bureaucrats, alcohol consumption is down slightly. More people abstain than a few years ago.
Endurance training in rats with chronic heart failure induced by myocardial infarction.
Authors: T I Musch, R L Moore, D J Leathers, A Bruno, R Zelis
Journal: Circulation (1986)

The response to exercise was investigated in trained and sedentary rats with moderate compensated heart failure produced by myocardial infarction (MI) and in rats that underwent sham operations. Trained rats ran on a treadmill (10% grade at 20 m/min) for 60 min/day, 5 days/week for 10 to 12 weeks, whereas sedentary rats had only limited activity. Maximal oxygen consumption normalized for body weight (ml kg-1 min-1) was determined for each rat and found to be (1) greater in trained rats when compared with sedentary rats and (2) greater in sham-operated rats when compared with their counterparts that suffered infarction. In addition, skeletal muscle succinate dehydrogenase activities were greater and the blood lactic acid response to submaximal exercise was lower in trained rats compared with sedentary rats. Left ventricular infarct size for sedentary and trained rats with infarction was 36 +/- 3% and 34 +/- 3% of the total endocardial circumference, respectively, and resulted in (1) elevated left ventricular end-diastolic pressures at rest and during exercise, (2) lower mean arterial pressures at rest, and (3) lower maximal heart rates when compared with those in their sham-operated counterparts. However, normalization of mean arterial pressures during submaximal and maximal exercise was found along with a trend toward normalization of maximal heart rate when trained rats with infarction were compared with their sedentary counterparts. Blood flows to the kidneys, organs of the gut, and skeletal muscle during both submaximal and maximal exercise were unaffected by either myocardial infarction or training; no differences between sedentary and trained rats with infarction and sedentary and trained sham-operated rats were found. These results demonstrate that an exercise training program of moderate intensity produces beneficial hemodynamic and metabolic effects in rats with moderate compensated heart failure.