tbuckley/cabot-search huggingface dataset:
MICROALBUMINURIA AT THE TIME OF PRESENTATION IS ASSOCIATED WITH CORONARY PLAQUE COMPONENTS: VIRTUAL HISTOLOGY-INTRAVASCULAR ULTRASOUND ANALYSIS
Authors: Young Joon Hong, Myung Ho Jeong, Yun Ha Choi, Daisuke Hachinohe, Khurshid Ahmed, Seung Hwan Hwang, Jum Suk Ko, Min Goo Lee, Keun Ho Park, Doo Sun Sim, Hyun Ju Yoon, Nam Sik Yoon, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang
Journal: Journal of the American College of Cardiology (2011)
Toxic shock syndrome after minor surgery.
Authors: M J Griffiths, D G Sinclair
Journal: BMJ (1993)

tuberculosis in health care workers in central France.I studied cases of tuberculosis in hospital em- ployees between 1984 and 1992.Sixty two cases of occupationally acquired tuberculosis occurred during this period.In all cases the employees had had BCG vaccination, but in 41 cases the tuberculosis occurred more than 15 years after the vaccination.The World Health Organisation and many authors consider that BCG vaccination gives about 80% protection, but only for 15 years.2Thus in these 41 cases the protection offered by BCG vaccination may have disappeared.Health care workers should have a tuberculin skin test at least every two years.A further BCG injection should be given if the result of the test is negative.In 44 cases in this study tuberculosis was detected by a routine chest x ray examination.Chest x ray screening, though more costly, is more effective than skin testing.As the number of patients admitted to hospital with HIV infection and tuberculosis increases, the risk of nosocomial transmission to staff may rise, and new thought must be given to prevention.
Concurrent chemo-radiation therapy for advanced hepatocellular carcinoma with portal vein thrombosis
Authors: Kwang-Hyub Han, Jinsuk Kim, Jaeyoun Cheong, Doyun Lee, Jinsil Seong, Sanghoon Ahn, Younghoon Youn, Chaeyoon Chon, Youngmyoung Moon
Journal: Journal of Hepatology (2002)
THE TEACHING OF PSYCHIATRY
Authors: CHARLES W. BURR
Journal: JAMA (1913)

A great deal has been written and spoken in recent years on educational reform. Much has been mere intellectual soapsuds, beautiful as the prismatic colors on the surface of a soap-bubble but having no more substance. Some of the criticisms of present methods have been wise, sane and practical, written by competent men not hunting for popular acclaim, and it is to be hoped that in the slow but steady progress of time, a progress rarely helped by noise, the opinions of these men will prevail, and that the reforms which they have suggested will be put into effect. To-day, however, the quiet man who knows, he whose words should carry weight and have authority, has less chance to be listened to than that other man who knows how to write or speak in the style of a newspaper headline. The newspapers and the cheap magazines have attempted to usurp
Transcriptional response in the unaffected kidney after contralateral hydronephrosis or nephrectomy
Authors: Peter Hauser, Alexander Kainz, Paul Perco, Helga Bergmeister, Christa Mitterbauer, Christoph Schwarz, Heinz M. Regele, Bernd Mayer, Timothy W. Meyer, Rainer Oberbauer
Journal: Kidney International (2005)
Periodic PSA-based screening in men 55 to 69 years of age reduced prostate cancer mortality
Authors: Richard M. Hoffman
Journal: Annals of Internal Medicine (2012)

ACP Journal Club17 July 2012Periodic PSA-based screening in men 55 to 69 years of age reduced prostate cancer mortalityRichard M. Hoffman, MD, MPHRichard M. Hoffman, MD, MPHNew Mexico VA Health Care System, Albuquerque, New Mexico, USA (R.M.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-2-201207170-02004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSchröder FH, Hugosson J, Roobol MJ, et al; ERSPC Investigators. Prostate-cancer mortality at 11 years of follow-up. N Engl J Med. 2012;366:981-90. https://pubmed.ncbi.nlm.nih.gov/22417251Clinical Impact RatingsGIM/FP/GP: Oncology: References1 Chou R, LeFevre ML. Prostate cancer screening—the evidence, the recommendations, and the clinical implications. JAMA. 2011;306:2721-2. [PMID: 22203543] Google Scholar2 Schröder FH, Hugosson J, Roobol MJ, et al; ERSPC Investigators. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009;360:1320-8. [PMID: 19297566] Google Scholar3 Andriole GL, Crawford ED, Grubb RL 3rd et al; PLCO Project Team. Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up. J Natl Cancer Inst. 2012;104:125-32. [PMID: 22228146] Google Scholar4 Moyer VA; US Preventive Services Task Force. Screening for prostate cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2012;156:880-91. Google Scholar5 Prasad SM, Drazer MW, Huo D, Hu JC, Eggener SE. 2008 US Preventive Services Task Force recommendations and prostate cancer screening rates. JAMA. 2012;307:1692-4. [PMID: 22535850] Google Scholar6 Loeb S, Vonesh EF, Metter EJ, et al. What is the true number needed to screen and treat to save a life with prostate-specific antigen testing? J Clin Oncol. 2011;29:464-7. [PMID: 21189374] Google Scholar7 Wolf AM, Wender RC, Etzioni RB, et al; American Cancer Society Prostate Cancer Advisory Committee. American Cancer Society guideline for the early detection of prostate cancer: update 2010. CA Cancer J Clin. 2010;60:70-98. [PMID: 20200110] Google Scholar Author, Article, and Disclosure InformationAffiliations: New Mexico VA Health Care System, Albuquerque, New Mexico, USA (R.M.H.)This article was published at Annals.org on 3 July 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 July 2012Volume 157, Issue 2Page: JC1-4KeywordsAge groupsAntigensBiopsyCancer screeningCancer treatmentLung and intrathoracic tumorsProstate cancerStatistical models ePublished: 17 July 2012 Issue Published: 17 July 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
T-lymphocyte cytotoxicity to HBsAg-coated target cells in hepatitis B virus infection
Authors: A. Alberti, G. Realdi, F. Bortolotti, A. M. Rigoli
Journal: Gut (1977)

The cytotoxic effect of peripheral lymphocytes on chicken red blood cells (ChRBC) coated with purified hepatitis B surface antigen (HBsAg) has been studied as an in vitro parameter of cell-mediated immunity in acute and chronic infection with hepatitis B virus. Using this technique, the mean cytotoxic index of lymphocytes from patients with acute hepatitis B (29.13 +/- 20.88) was significantly higher than that obtained with lymphocytes from control subjects (6.53 +/- 3.75). Only 33.3% of the patients with HBsAg-positive chronic active hepatitis exhibited lymphocyte cytotoxicity to HBsAg-coated target cells and the mean cytotoxic index (11.66 +/- 6.60) was in these cases significantly lower than that found in acute hepatitis B. Healthy chronic carriers of HBsAg failed to show lymphocyte cytotoxicity to target cells. The effector cells detected in acute hepatitis B by this in vitro assay have been demonstrated to be T-lymphocytes, as T-cell depleted subpopulations lacked cytotoxic activity. Target cell lysis could be blocked by addition of HBsAg-coated unlabelled ChRBC as well as of purified HBsAg in the culture tubes. It is suggested that damage to the liver cells in acute hepatitis B is related to the presence of cytotoxic T-lymphocytes reacting with HBsAg on the surface of infected hepatocytes. An inadequate lymphocyte response to the antigen may be responsible for the persistence of the infection in the liver with varied clinical manifestations and associated hepatic lesions.
Heart disease prevention project: a randomised controlled trial in industry.
Authors: G Rose, R F Heller, H T Pedoe, D G Christie
Journal: BMJ (1980)

Twenty-four factories or other occupational groups, employing 18 210 men aged 40 to 59, were formed into matched pairs. One of each pair was allocated randomly to receive a five to six year programme of medical examinations and intervention to reduce the levels of the main coronary risk factors. Men at factories in the intervention group were given advice on dietary reduction of plasma cholesterol concentrations, stopping or reducing cigarette smoking, regular exercies for the sedentary and reduced energy intake for the overweight, and hypertension was treated. The programme was delivered mainly through existing occupational medical services, helped by a small central staff. Personal consultations were largely confined to men with a high risk of developing coronary heart disease. Changes in risk factors were assessed by regular standardised examinations of random samples of men. The spread of information by general propaganda proved easy, but a change in habits seemed to require personal contact. Small but significant reductions occurred, mainly in the high-risk group, but these were not sustained when pressure was relaxed.
Physician Manipulation of Reimbursement Rules for Patients
Authors: Matthew K. Wynia, Deborah S. Cummins, Jonathan B. VanGeest, Ira B. Wilson
Journal: JAMA (2000)

Context Health plan utilization review rules are intended to enforce insurance contracts and can alter and constrain the services that physicians provide to their patients.Physicians can manipulate these rules, but how often they do so is unknown.Objective To determine the frequency with which physicians manipulate reimbursement rules to obtain coverage for services they perceive as necessary, and the physician attitudes and personal and practice characteristics associated with these manipulations. Design, Setting, and ParticipantsA random national sample of 1124 practicing physicians was surveyed by mail in 1998; the response rate was 64% (n = 720).Main Outcome Measure Use of 3 different tactics "sometimes" or more often in the last year: (1) exaggerating the severity of patients' conditions; (2) changing patients' billing diagnoses; and/or (3) reporting signs or symptoms that patients did not have to help the patients secure coverage for needed care. ResultsThirty-nine percent of physicians reported using at least 1 tactic "sometimes" or more often in the last year.In multivariate models comparing these physicians with physicians who "never" or "rarely" used any of these tactics, physicians using these tactics were more likely to (1) believe that "gaming the system" is necessary to provide high-quality care today (odds ratio [OR], 3.67; 95% confidence interval [CI], 2.54-5.29);(2) have received requests from patients to deceive insurers (OR, 2.44; 95% CI, 1.72-3.45);(3) feel pressed for time during patient visits (OR, 1.69; 95% CI, 1.21-2.37);and (4) have more than 25% of their patients covered by Medicaid (OR, 1.60; 95% CI, 1.08-2.38).Notably, greater worry about prosecution for fraud did not affect physicians' use of these tactics (P = .34).Of those reporting using these tactics, 54% reported doing so more often now than 5 years ago.Conclusions A sizable minority of physicians report manipulating reimbursement rules so patients can receive care that physicians perceive is necessary.Unless novel strategies are developed to address this, greater utilization restrictions in the health care system are likely to increase physicians' use of such manipulative "covert advocacy" tactics.
Making trade work for public health
Authors: N. Drager
Journal: BMJ (1999)

Recent trade disagreements over hormone treated beef, genetically modified foods, and antiretroviral drugs have captured the public interest and revealed the tensions between national public health policies and the need to comply with trade agreements overseen by the World Trade Organisation. A new round of global trade negotiations will be on the agenda next month at the World Trade Organisation's ministerial conference, and the World Health Organisation will attend the talks to ensure that the voice of public health is heard.

The World Trade Organisation is the forum for negotiating trade agreements and resolving trade disputes between countries. It was established in 1995 to provide the institutional and legal foun-dation for the multilateral trading system, which is designed to permit trade to flow as freely as possible worldwide without undesirable side effects. The underlying assumption is that human welfare will increase through economic growth fuelled by trade liberalisation.

The General Agreements on Tariffs and Trade (GATT), adopted in 1948, focused on …
125 SIDE CHAIN MODIFIED BILE ACIDS MODULATE ENDOPLASMIC RETICULUM STRESS IN MDR2−/− MICE IN VIVO AND BILE DUCT EPITHELIAL CELLS IN VITRO
Authors: T. Moustafa, E. Halilbasic, P. Fickert, A. Fuchsbichler, J. Gumhold, D. Silbert, H. Denk, M. Trauner
Journal: Journal of Hepatology (2008)
Collagenase Production In Vitro by Tissue From a Rheumatoid Nodule.
Authors: Edward D. Harris
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Collagenase Production In Vitro by Tissue From a Rheumatoid Nodule.Edward D. Harris Jr., M.D., F.A.C.P.Edward D. Harris Jr., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-881_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSynovial lesions of rheumatoid arthritis are morphologically nonspecific, whereas the histopathology of subcutaneous nodules is relatively specific for diagnosis. Biochemical similarities between the synovial and nodule lesions of rheumatoid arthritis were sought by studying collagenase released by rheumatoid nodules in culture in vitro. One nodule, 2 x 3 cm, from the olecranon bursa of a 47-year-old woman with rheumatoid arthritis was cut into 2-x-2-cm explants and cultured at 37 °C in media without serum in 95% O2, 5% CO2for 1 week, with and without colchicine (0.1 μg/ml) in the media. Media were harvested daily. Collagenolytic activity, assayed using14C-labeled... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Edward D. HarrisJr., M.D., F.A.C.P.Affiliations: Hanover, N.H. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 881-881KeywordsColchicineCollagenasesHistopathologyLesionsRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
The Control of Dicumarol Therapy in Myocardial Infarction by a Simple Blood Prothrombin Test
Authors: BENJAMIN MANCHESTER, BORIS RABKIN
Journal: Circulation (1954)

Effective anticoagulant therapy is dependent upon adequate and reliable blood prothrombin determinations. The initiation of such therapy usually requires hospitalization. The currently available blood prothrombin tests require special laboratory facilities and trained personnel. The authors of this report present the results of Dicumarol in myocardial infarction and a simple blood prothrombin test for the control of such anticoagulant therapy. The test has been employed for more than eight years. The method has proved to be simple, accurate, and practical, and has made anticoagulants possible for patients at home as well as in the hospital.
Impact of the learning curve on outcomes after percutaneous mitral valve repair with MitraClip <sup>®</sup> and lessons learned after the first 75 consecutive patients
Authors: Wolfgang Schillinger, Thomas Athanasiou, Ninja Weicken, Lars Berg, Tobias Tichelbäcker, Miriam Puls, Mark Hünlich, Rolf Wachter, Hans‐Joachim Helms, Ralf Seipelt, Friedrich A. Schöndube, Gerd Hasenfuss
Journal: European Journal of Heart Failure (2011)

Aims Mitral valve regurgitation plays a significant role in the aetiology and course of heart failure. We investigated the impact of the learning curve on outcomes after percutaneous mitral valve repair with MitraClip. Methods and results Outcomes of the first 75 consecutive patients treated with MitraClip at our centre were stratified by subsequent treatment periods (25 patients each). Median total procedure time and device time decreased from 180 and 105 min in period 1 to 95 and 55 min in period 3 (P < 0.005 each). There was an excess of total safety events in period 1 (n = 16) that decreased in periods 2 and 3 (n = 6 and 3, P = 0.0003). Acute procedural success [APS; clip successfully placed and mitral regurgitation (MR) grade ≤2+ at discharge] was 80% in periods 1 and 2, but 92% in period 3 (P = 0.46). At 6 months, improvement in durability and completeness of mitral valve repair was evident: 89.4% of patients in period 3 and 65.0% in period 1 had MR ≤2+ at 6 months (P = 0.03). Within 30 days, no patient sustained myocardial infarction or stroke, and mortality was 2.7% for all patients without significant differences regarding periods. Furthermore, while treatment period did not affect mid-term survival and hospitalization for heart failure, failure of APS, STS (Society of Thoracic Surgeons) score ≥15%, and overt right heart failure at baseline predicted increased mortality. Conclusion MitraClip showed a learning curve regarding mid-term durability and completeness of mitral valve repair, and APS predicted mortality. Recently published studies should be interpreted in consideration of these findings.
Ultraviolet light treatment delays contact sensitization to nitrogen mustard
Authors: KENNETH M. HALPRIN, MARY COMERFORD, STEPHEN E. PRESSER, J.RICHARD TAYLOR
Journal: British Journal of Dermatology (1981)

Journal Article Ultraviolet light treatment delays contact sensitization to nitrogen mustard Get access KENNETH M. HALPRIN, KENNETH M. HALPRIN Veterans Administration Medical Center, 1201 NW 16th Street, Miami, Florida 33125, and Department of Dermatology, University of Miami School of Medicine, Miami, Florida, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar MARY COMERFORD, MARY COMERFORD Veterans Administration Medical Center, 1201 NW 16th Street, Miami, Florida 33125, and Department of Dermatology, University of Miami School of Medicine, Miami, Florida, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar STEPHEN E. PRESSER, STEPHEN E. PRESSER Veterans Administration Medical Center, 1201 NW 16th Street, Miami, Florida 33125, and Department of Dermatology, University of Miami School of Medicine, Miami, Florida, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J.RICHARD TAYLOR J.RICHARD TAYLOR Veterans Administration Medical Center, 1201 NW 16th Street, Miami, Florida 33125, and Department of Dermatology, University of Miami School of Medicine, Miami, Florida, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue 1, 1 July 1981, Pages 71–76, https://doi.org/10.1111/j.1365-2133.1981.tb00884.x Published: 01 July 1981 Article history Accepted: 09 September 1980 Published: 01 July 1981
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
Authors: Damian B. Yap, Justin Chu, Tobias Berg, Matthieu Schapira, S.-W. Grace Cheng, Annie Moradian, Ryan D. Morin, Andrew J. Mungall, Barbara Meissner, Merrill Boyle, Victor E. Marquez, Marco A. Marra, Randy D. Gascoyne, R. Keith Humphries, Cheryl H. Arrowsmith, Gregg B. Morin, Samuel A. J. R. Aparicio
Journal: Blood (2010)
Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro
Authors: R. A. Giannella, S. A. Broitman, N. Zamcheck
Journal: Gut (1972)

Reassessment of the `gastric bactericidal barrier9 to enteric bacteria in man included studies of the bactericidal activity of (1) the normal and achlorhydric stomach <i>in vivo</i> and (2) normal and achlorhydric gastric juice and other media <i>in vitro.</i> Within 30 minutes virtually all bacteria (<i>Serratia marcescens</i>) were eliminated in the normal stomach whereas no reduction occurred in the achlorhydric stomach in one hour. <i>In vitro</i>, identical bactericidal activity was observed at the same <i>p</i>H (from 2·0 to 7·0) in normal gastric juice, achlorhydric gastric juice, aqueous HCl, and nutrient broth. At <i>p</i>H less than 4·0, 99·9% of the bacteria were killed within 30 minutes. The presence of profuse bacterial flora, including coliforms, found in markedly acid-deficient but not in normal stomachs, correlates well with the absence of bactericidal activity. Thus, the `gastric bactericidal barrier9 is primarily <i>p</i>H-hydrochloric acid dependent, with other constituents of gastric juice contributing little, if any, detectable effect on the destruction of microorganisms.
Positive findings of mammography may lead to suicide
Authors: J G Weil, J I Hawker
Journal: BMJ (1997)

During V(D)J recombination, recognition and cleavage of the recombination signal sequences (RSSs) requires the coordinated action of the recombination-activating genes 1 and 2 (RAG1/RAG2) recombinase complex. In this report, we use deletion mapping and site-directed mutagenesis to determine the minimal domains critical for interaction between RAG1 and RAG2. We define the active core of RAG2 required for RSS cleavage as aa 1–371 and demonstrate that the C-terminal 57 aa of this core provide a dominant surface for RAG1 interaction. This region corresponds to the last of six predicted kelch repeat motifs that have been proposed by sequence analysis to fold RAG2 into a six-bladed β-propeller structure. Residue W317 within this sixth repeat is shown to be critical for mediating contact with RAG1 and concurrently for stabilizing binding and directing cleavage of the RSS. We also show that zinc finger B (aa 727–750) of RAG1 provides a dominant interaction domain for recruiting RAG2. In all, the data support a model of RAG2 as a multimodular protein that utilizes one of its six faces for establishing productive contacts with RAG1.
Combating a Deadly Combination: Intravenous Drug Abuse, Acquired Immunodeficiency Syndrome
Authors: Chris Anne Raymond
Journal: JAMA (1988)

1988 COULD be a year of particular focus on the intravenous drug abuser. A study released recently by Stephen C. Joseph, MD, health commissioner of New York City, and colleagues has renewed attention to the role of intravenous drug users in the epidemiology of acquired immunodeficiency syndrome (AIDS). Across the country, public health experts are devising new strategies to staunch the tide of human immunodeficiency virus (HIV) infections in this population. But these same experts say that characteristics of the illicit drug culture, as well as political constraints, may hinder their efforts. The New York study, reported at the annual meeting of the American Public Health Association, found that the number of AIDS-related deaths among intravenous drug abusers actually exceeded those occurring in homosexual men in New York. In a review of medical records of drug-related deaths, 2520 additional deaths attributed to AIDS were uncovered that were excluded in official
612 WEEK 8 HCV-RNA IS THE OPTIMAL PREDICTOR OF RELAPSE IN NON-RVR PATIENTS WITH GENOTYPE 1/4 RANDOMISED TO 48 OR 72 WEEKS PEG-IFN ALFA-2A PLUS RBV
Authors: T.-M. Scherzer, H. Kerschner, S. Beinhardt, K. Rutter, H. Hofer, P. Steindl-Munda, T. Popow-Kraupp, P. Ferenci
Journal: Journal of Hepatology (2009)