tbuckley/cabot-search huggingface dataset:
Problems with a no-fault system of accident compensation.
Authors: R Smith
Journal: BMJ (1982)

The New Zealand system of no-fault accident compensation, which I described in my last article, is there to stay. Everybody I spoke to?from the managing director of the Accident Compen? sation Corporation to taxidrivers?was agreed on that. The scheme inevitably has its problems, and it will change and pro? gress, but compensation seems to be faster, fairer, and more available than under the old system, and the country?even in these difficult times?has been able to afford the scheme. Having made it clear that the scheme is essentially a success, I want now to discuss its problems. Reading the New Zealand press, you might think that the main problems were abuse by some claimants (compo kings) and, at the same time, failure by the Accident Compensation Corporation to compensate deserving cases. Abuses will occur in any system, and there is no evidence that abuse is a serious problem. But the failure to compensate what the press regard as deserving cases reflects one of the deeper problems of the Acci? dent Compensation Corporation?deciding what is and what is not an accident.
ACTIVE SUPPRESSION OF IMMUNOGLOBULIN ALLOTYPE SYNTHESIS
Authors: Leonore A. Herzenberg, Eva L. Chan, Myrnice M. Ravitch, Roy J. Riblet, Leonard A. Herzenberg
Journal: The Journal of Experimental Medicine (1973)

Thymus-derived cells (T cells) that actively suppress production of IgG2a immunoglobulins carrying the Ig-1b allotype have been found in adult (SJL x BALB/c)F(1) mice exposed to anti-Ig-1b early in life. The suppression is specific for Ig-1b. The allelic product, Ig-1a, is unaffected. Spleen, lymph node, bone marrow, or thymus cells from suppressed mice suppress production of Ig-1b by syngeneic spleen cells from normal F(1) mice. When a mixture of suppressed and normal cells is transferred into lethally irradiated BALB/c mice, there is a short burst of Ig-1b production after which Ig-1b levels in the recipient fall rapidly below detectability. Pretreatment of the cells from the suppressed mice with antiserum specific for T cells (anti-Thy-1b) plus complement before mixture destroys the suppressing activity. Similar results with suppressor cells were obtained in vitro using Mishell-Dutton cultures. Mixture of spleen cells from suppressed animals with sheep erythrocyte (SRBC)-primed syngeneic normal spleen before culture suppresses Ig-1b plaque-forming cell (PFC) formation while leaving Ig-1a PFC unaffected. Treatment of the suppressed spleen with anti-Thy-1b before transfer removes the suppressing activity.
Points: Are biochemical tests of thyroid function of any value in monitoring patients receiving thyroxine therapy?
Authors: R J Mardell, T R Gamlen
Journal: BMJ (1987)

in addition to Doppler studies.If they judged, again exclusively by their interpretation of the femoral pulse, that there was some aortoiliac disease then blind aortoiliac surgery was advocated in addition to the distal surgery.If angiography showed a localised iliac stenosis we would proceed to angioplasty.This procedure alone might improve the patient's clinical condition or it might subsequently be necessary to proceed to bypass surgery or further angioplasty.Whereas we advocate and use extensively Doppler ultrasound in the management of peripheral vascular disease, we see it as a critical adjunct to angiography in the combined treatment of patients with peripheral vascular disease by both the surgeon and the radio- logist.1
Hemodynamic and humoral characteristics of hypertension induced by prolonged stellate ganglion stimulation in conscious dogs.
Authors: J F Liard, R C Tarazi, C M Ferrario, W M Manger
Journal: Circulation Research (1975)

Recent evidence has suggested that cardiac factors may play a role in the evolution of arterial hypertension. To test the possibility that an increase in cardiac-performance can lead to a sustained increase in systemic blood pressure, we electrically stimulated the left stellate ganglion of six conscious dogs continuously for a 7-day period and monitored cardiac output and arterial blood pressure. In all six dogs, stimulation elicited an abrupt rise in systemic blood pre-sure that was entirely due to rise in cardiac output that lasted at least 6 hours. After 1 day of continuous stimulation, cardiac output retured to control values, but blood pressure remained elevated. After 7 days of stimulation, blood pressure was increased by an average of 25 mm Hg and peripheral resistance by 35 plus and minus 4%. Measurements of blood volume, plasma renin activity, circulating catecholamines (three of the six dogs), and sodium balance showed that none of these factors could explain the development pf this sustained hypertension. Pharmacologic blockade with phenoxybenzamine prevented in large part the rise in blood pressure in short-term stellate ganglion stimulations, whereas propranolol had very little effect on the pressor response, although it nearly abolished the increase in cardiac output. The data indicate that continuous stimulation of the stellate ganglion in conscious dogs leads to substained rises in both blood pressure and peripheral resistance; these changes are apparently mediated by increased activity of the sympathetic nervous system.
Precision Medicine to Improve the Risk and Benefit of Cancer Care
Authors: Howard L. McLeod
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN EVALUATION OF MANIC-DEPRESSIVE PSYCHOSIS IN THE LIGHT OF FOLLOW-UP STUDIES
Authors: PAUL HOCH, H. L. RACHLIN
Journal: American Journal of Psychiatry (1941)

Many cases which were originally diagnosed as manic-depressives were subsequently reclassified as schizophrenia. Review of New York State and Federal statistics for other states show: (a) Marked fluctuation in the number of manic-depressives as compared with dementia præcox and in relation to total admissions. A complete reversal of the general trend in some states. Special case studies reveal that errors in diagnosis result from the failure to apply the established criteria of symptomatology. A need for periodic reconsideration of diagnosis is indicated.
High-Energy Extracorporeal Shock-Wave Therapy for Treating Chronic Calcific Tendinitis of the Shoulder
Authors: Raveendhara R. Bannuru, Nina E. Flavin, Elizaveta Vaysbrot, William Harvey, Timothy McAlindon
Journal: Annals of Internal Medicine (2014)

Calcific and noncalcific tendinitis of the shoulder can be unresponsive to conventional therapies. Extracorporeal shock-wave therapy (ESWT) has been suggested as an alternative treatment.To assess the efficacy of ESWT in patients with calcific and noncalcific tendinitis.MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, Web of Science, and Google Scholar were searched up to 1 November 2013.Randomized, controlled trials (RCTs) comparing high-energy versus low-energy ESWT or placebo for treatment of calcific or noncalcific tendinitis of the shoulder. Outcome measures included pain (visual analogue scale score), functional assessment (Constant-Murley score), and resolution of calcifications.Three independent reviewers abstracted data and determined eligibility and quality by consensus.Twenty-eight RCTs met the inclusion criteria. Studies were heterogeneous. Twenty RCTs compared ESWT energy levels and placebo and consistently showed that high-energy ESWT was significantly better than placebo in decreasing pain and improving function and resorption of calcifications in calcific tendinitis. No significant difference was found between ESWT and placebo in treatment of noncalcific tendinitis.The number of RCTs was small, and the studies were heterogeneous.High-energy ESWT is effective for improving pain and shoulder function in chronic calcific shoulder tendinitis and can result in complete resolution of calcifications. This therapy may be underutilized for a condition that can be difficult to manage.None.
CD38-Targeted Immunochemotherapy in Refractory Multiple Myeloma: A New Horizon
Authors: Jacob P. Laubach, Paul G. Richardson
Journal: Clinical Cancer Research (2015)

CD38 is a type II transmembrane glycoprotein that is highly expressed in multiple myeloma and is a promising target for immunotherapy. Daratumumab is a human monoclonal antibody that has potent anti-multiple myeloma activity both as monotherapy and in combination with other multiple myeloma treatments, and has breakthrough designation on this basis.
Super-Selective Arteriography of the External Carotid Artery
Authors: Oscar Sugar
Journal: JAMA (1978)

The branches of the external carotid artery and their ramifications can now be made visible in the living human by injection of radiopaque materials into this artery. The territories of each branch overlap. The late Dr Djindjian and his collaborators have systematically studied the territory of each branch by opacification of the individual arteries arising from each major branch of the external carotid artery. The numberous variations in distribution and the collaterals that connect the branches on each side and from one side to the other can now be shown. On such a base of normal anatomy, the authors have now constructed a surprisingly extensive body of knowledge of pathological processes. Not only can obvious vascular malformations and tumors be shown, but also the blood supply to lesions of such small size that surgery or other treatment is neglected. The same technical advances have permitted improved therapy by embolization through
Sub-mitochondrial and sub-microsomal distribution of creatine kinase in guinea pig myocardium
Authors: E. A. OGUNRO, T. J. PETERS, G. WELLS, D. J. HEARSE
Journal: Cardiovascular Research (1979)

Journal Article Sub-mitochondrial and sub-microsomal distribution of creatine kinase in guinea pig myocardium Get access EDWARD A. OGUNRO, EDWARD A. OGUNRO 1 From the Cardiovascular Research Unit and Department of Medicine Royal Postgraduate Medical School, Hammersmith Hospital, and The Myocardial Metabolism Research Laboratories, The Rayne Institute, St. Thomas Hospital, London 1Reprint requests and correspondence to: Edward A. Ogunro, Ph.D., Department of Medicine, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois 60611, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar T. J. PETERS, T. J. PETERS From the Cardiovascular Research Unit and Department of Medicine Royal Postgraduate Medical School, Hammersmith Hospital, and The Myocardial Metabolism Research Laboratories, The Rayne Institute, St. Thomas Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar G. WELLS, G. WELLS From the Cardiovascular Research Unit and Department of Medicine Royal Postgraduate Medical School, Hammersmith Hospital, and The Myocardial Metabolism Research Laboratories, The Rayne Institute, St. Thomas Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar D. J. HEARSE D. J. HEARSE From the Cardiovascular Research Unit and Department of Medicine Royal Postgraduate Medical School, Hammersmith Hospital, and The Myocardial Metabolism Research Laboratories, The Rayne Institute, St. Thomas Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 13, Issue 10, October 1979, Pages 562–567, https://doi.org/10.1093/cvr/13.10.562 Published: 01 October 1979
The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor.
Authors: F L Owen, R Riblet, B A Taylor
Journal: The Journal of Experimental Medicine (1981)

The mouse T cell alloantigen, Tsud, is expressed on a minority of mature, Lyt-2+ cells, and its expression is controlled by a gene linked to the immunoglobulin heavy chain gene cluster, Igh. Tsud can be assayed by immunofluorescence staining with an antiserum made in BALB/c mice against C.AL-20 concanavalin A blasts. This antiserum can also be used to induced T suppressor cells in mice expressing Tsu(d). Both of these assays were used to type several panels of recombinant inbred strains and Igh recombinant strains to accurately map the Tsu(d) locus. The Tsu(d) gene is located very near the heavy chain constant-region genes, Igh-C, on the side toward the prealbumin gene, Pre-1. Tsu(d) is not among the heavy chain variable-region genes, Igh-V, and thus is not a variable-region framework allotype, subgroup determinant, or idiotype. The map position suggest that the Tsu(d) antigen is a constant region allotypic determinant on the as yet uncharacterized T cell receptor.
Perceived behavioural determinants of participation in leisure activities of junior and senior civil servants of Sokoto State
Authors: Emmanuel J Chom, Aminu S Shuaibu, Venkateswarlu Kankanala
Journal: British Journal of Sports Medicine (2010)

The success of any recreation programme organised either by private sector or by public sector depends largely on the acceptability, and affordability of the participants. It is therefore necessarily to determine the needs and interest of the target population. This study was conduct to find out the reasons for participation in leisure activities with regards to values and ideas, which vary from person to person from community to community and from culture to culture. The purpose of this study was therefore, to investigate the behavioural determinants of participation in leisure activities of junior and senior civil servants of Sokoto State. The behavioural determinant of participation included reasons for participation, obstacles for participation, attitude towards participation, subjective norms for participation, perceived behavioural control for participation role identify for participation, socialisation for participation, creative and artistic activities for participation, intellectual activities for participation and sports activities for participation. To achieve the purpose of this study a self developed and standardised questionnaire was administered on 400 junior and senior civil servants of Sokoto State selected by using simple convenient sampling technique. The results of this study showed significant differences between junior and senior civil servants in their obstacles for participation, norms for participation and creative and artistic activities for participation.
Long-term hemodynamic effects of ketanserin, a 5-hydroxytryptamine blocker, in portal hypertensive patients
Authors: Julio Vorobioff, Guadalupe Garcia-Tsao, Roberto Groszmann, Guillermo Aceves, Eduardo Picabea, Roberto Villavicencio, Jorge Hernandez-Ortiz
Journal: Hepatology (1989)

Ketanserin, a 5-hydroxytryptamine-2 receptor blocker, has been shown to decrease portal pressure in recent acute hemodynamic studies that have been performed both in experimental animals and portal hypertensive patients. The present study was designed to investigate the effects of chronic oral administration of ketanserin in portal hypertensive patients with cirrhosis. The mean baseline hepatic venous pressure gradient in the 13 patients with alcoholic cirrhosis who completed the study was 15.7 +/- 2.7 mmHg. It decreased significantly to 13.3 +/- 2.0 mmHg (p less than 0.001) after ketanserin was administered at a mean dose of 51 mg per day for a mean period of 32 days. This 14.6% reduction in hepatic venous pressure gradient resulted mainly from a decrease in mean wedged hepatic venous pressure (from 22.2 +/- 4.0 to 20.1 +/- 3.6 mmHg) and was accompanied by significant decreases in cardiac index (18.8%) and in mean arterial pressure (8.1%). However, changes in cardiac index or in mean arterial pressure were not predictive of modifications in the hepatic venous pressure gradient. Eight of 16 patients entered in the study developed side effects, the most significant being a reversible portosystemic encephalopathy, which occurred in three patients who had poor liver function. This study confirms evidence in favor of a role for 5-hydroxytryptamine in portal hypertension and adds a new group of agents for the chronic treatment of portal hypertensive patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Angioedema as a Complication of Upper Endoscopy
Authors: Christopher Lawrence, M Khalouck Abdrabbo
Journal: Annals of Internal Medicine (2003)

Letters5 August 2003Angioedema as a Complication of Upper EndoscopyChristopher Lawrence, MD and M Khalouck Abdrabbo, MDChristopher Lawrence, MDUniversity of Virginia; Charlottesville, VA 22908 (Lawrence, Abdrabbo)Search for more papers by this author and M Khalouck Abdrabbo, MDUniversity of Virginia; Charlottesville, VA 22908 (Lawrence, Abdrabbo)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-3-200308050-00021-w3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: To our knowledge, angioedema has been reported as a complication of upper endoscopy only once in the English-language literature (1). We report what we believe to be the second case of angioedema occurring in the context of esophagogastroduodenoscopy. In the initial case report, Yakel and colleagues (1) attributed angioedema to midazolam. Here, we suggest that the cause was topical benzocaine spray (Hurricaine Spray, Beutlich Pharmaceuticals, Waukegan, Illinois). Benzocaine is routinely used for oropharyngeal anesthesia in many endoscopy centers, although not without some risk. The infrequent, sometimes fatal complication of methemoglobinemia is well recognized, but benzocaine has ...References1. Yakel DL, Whittaker SE, Elstad MR. Midazolam-induced angioedema and bronchoconstriction. Crit Care Med. 1992;20:307-8. [PMID: 1737464] CrossrefMedlineGoogle Scholar2. Lorelli DR, Morris DE, Lewis JW. Drug-induced methemoglobinemia during thoracoscopic lung biopsy. Ann Thorac Surg. 2001;71:703-5. [PMID: 11235734] CrossrefMedlineGoogle Scholar3. Nguyen ST, Cabrales RE, Bashour CA, Rosenberger TE, Michener JA, Yared JP, . Benzocaine-induced methemoglobinemia. Anesth Analg. 2000;90:369-71. [PMID: 10648323] MedlineGoogle Scholar4. Buckley AB, Newman A. Methemoglobinemia occurring after the use of a 20% benzocaine topical anesthetic prior to gastroscopy [Letter]. Gastrointest Endosc. 1987;33:466-7. [PMID: 3443276] CrossrefMedlineGoogle Scholar5. Gunaratnam NT, Vazquez-Sequeiros E, Gostout CJ, Alexander GL. Methemoglobinemia related to topical benzocaine use: is it time to reconsider the empiric use of topical anesthesia before sedated EGD? Gastrointest Endosc. 2000;52:692-3. [PMID: 11060205] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Virginia; Charlottesville, VA 22908 (Lawrence, Abdrabbo) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byType II Hereditary Angioedema—Presenting as Food Allergy 5 August 2003Volume 139, Issue 3Page: W-62KeywordsAnesthesiaEdemaEndoscopyErythropoietinEsophagogastroduodenoscopySedationSleep apneaSteroidsSurgical repairTongue ePublished: 5 August 2003 Issue Published: 5 August 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Comparison of Atenolol and Metoprolol Once Daily on Blood Pressure during Rest and Exercise
Authors: B.E. Karlberg, J.-H. Attenhög, J. Castenfors, L. Forfelt, O.R. Nilsson, T. Thulin, K. Tolagen, S. Wettre, K.P. Öhman
Journal: Drugs (1983)
Free Technetium: Potential Pitfall in the Diagnosis of Renovascular Hypertension
Authors: Angela Hunsche, Gabriel B. Grossman, James R. Galt, Raghuveer K. Halkar
Journal: Clinical Nuclear Medicine (2004)

A 22-year-old woman had renography, including baseline and angiotensin-converting enzyme (ACE) inhibitor-assisted studies, in an evaluation for renovascular hypertension (RVH). Baseline renal scintigraphy performed with Tc-99m mercaptoacetyltriglicine (MAG3) was interpreted as normal. The study performed after ACE inhibitor administration showed abnormal time-activity curves suggesting the possibility of RVH. However, abnormal uptake in the left upper quadrant of the abdomen raised the possibility of inadvertent administration of free Tc-99m. A definitive diagnosis could not be made. An ACE inhibitor-assisted scan repeated 6 days later was normal.
Cancer rates in Europe are linked to overweight, experts warn
Authors: C. White
Journal: BMJ (2003)

Overweight and obesity account for over 50 000 “avoidable” cases of cancer in European Union countries every year, 9000 of which are in the United Kingdom alone.

Speaking at a conference in London on obesity, nutrition, and cancer last week, organised by the World Cancer Research Fund and sponsored by the Department of Health, experts warned that the rapidly rising prevalence of obesity is taking a huge toll on global health.

Obesity is thought to increase the overall risk of cancer by 25% in men and 37% in women, and it particularly …