tbuckley/cabot-search huggingface dataset:
Effects on virological and immunological parameters during CD34 mobilization in HIV patients with lymphoma
Authors: Maria Teresa Bortolin, Cecilia Simonelli, Stefania Zanussi, Chiara Pratesi, Ettore Bidoli, Maurizio Rupolo, Massimiliano Berretta, Rosamaria Tedeschi, Paolo De Paoli
Journal: American Journal of Hematology (2006)

The effects of CD34 mobilization with chemotherapy and G-CSF administration were evaluated in 13 HIV-positive patients with relapsed lymphomas and low CD4 counts. After mobilization, CD4+ cells increased significantly while HIV-RNA and integrated HIV-DNA showed no increases. G-CSF led to an increase of CD4+ cells with limited effects on HIV replication.
Advances in Molecular Genetics and Management of Hypertrophic Cardiomyopathy
Authors: Lameh Fananapazir
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular evolution of the COX7A gene family in primates
Authors: T. R. Schmidt, M. Goodman, L. I. Grossman
Journal: Molecular Biology and Evolution (1999)

COX VIIa is one of 10 nuclear-encoded subunits of the COX holoenzyme, and one of three that have isoforms with tissue-specific differences in expression. Analysis of nucleotide substitution rates revealed an accelerated rate of nonsynonymous substitutions relative to that of synonymous substitutions for the heart isoform gene (COX7AH) in six primate lineages. Rate accelerations have been noted for four other COX-related genes in this time period, suggesting that the COX holoenzyme has experienced an episode of adaptive evolution. A third member of the gene family, COX7AR, has recently been described. Although its function is currently unknown, low nonsynonymous substitution/synonymous substitution (N/S) ratios in mammalian evolution suggest that COX7AR is of functional importance. When the COX7A isoforms were divided into domains, examination of nucleotide substitution rates suggested that mitochondrial targeting residues experienced an accelerated nonsynonymous substitution rate in the period following gene duplication. In contrast, paralogous comparisons of the targeting residues of each isoform show they have been relatively conserved in mammalian evolution. This pattern is consistent with the evolution of tissue-specific function.
Renal Tubule and Wilson's Disease
Authors: Robert E. Hodges, Walter M. Kirkendall
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 May 1972Renal Tubule and Wilson's DiseaseROBERT E. HODGES, M.D., WALTER M. KIRKENDALL, M.D.ROBERT E. HODGES, M.D.Search for more papers by this author, WALTER M. KIRKENDALL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-835_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Elsas and colleagues "Wilson's Disease with Reversible Renal Tubular Dysfunction" (1), called attention to a lupus erythematosus-like syndrome that occurred after 27 months of treatment with D-penicillamine. Cessation of therapy with penicillamine resulted in "progressive renal tubular impairment." The authors concluded that penicillamine not only initiated a lupus-like syndrome but that copper deposition was the apparent cause of proximal renal tubular dysfunction.In March of 1956 (2) we published an article describing kidney function in four patients with Wilson's disease. We suggested that the functional renal defect was confined to the proximal convoluted tubules...References1. ELSASHAYSLETTSPARGO LJB: Wilson's disease with reversible renal tubular dysfunction. Correlation with proximal tubular ultrastructure. Ann Intern Med 75:427-433, 1971 LinkGoogle Scholar2. HODGESKIRKENDALLGUBLER RWC: Some aspects of kidney function in hepatolenticular degeneration (Wilson's disease). J Lab Clin Med 47:337-342, 1956 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT E. HODGES, M.D.; WALTER M. KIRKENDALL, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Fanconi SyndromeCarnitine metabolism in patients with chronic liver disease 1 May 1972Volume 76, Issue 5Page: 835-836KeywordsRenal diseases ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Developments have been made on cardiac surgical audit in Bristol
Authors: B. E Keogh, J. Dussek, L. Hamilton
Journal: BMJ (1999)

EDITOR—The cardiac surgical community is trying to address some of Shortis and Winkler's concerns about the Bristol affair.1

Congenital cardiac surgery represents a tenth of cardiac surgery in the United Kingdom. Its complexity and small numbers make individual surgical audit difficult. However, the Society of Cardiothoracic Surgeons of Great Britain and Ireland has defined repair of aortic coarctation and ventriculoseptal defect as surgeon specific marker operations for congenital cardiac surgery. Throughout the United Kingdom in 1997-8, 238 operations for simple coarctation were performed by 27 surgeons, with only one death. Similarly, 302 operations for isolated ventriculoseptal defect were performed by a slightly different group of 27 surgeons, with only …
Post-Penicillin Jaundice
Authors: R. R. Hughes
Journal: BMJ (1946)

TETRA-ETHYL LEAD POISONING MEDICAL URNAL685reported to have said that he had worked with petrol all his life and it had never hurt him.One charge-hand, another severe case, thought that fifteen years of work with petrol absolved him from the necessity for taking precautions.Treatment All that is necessary in the milder cases is removal from exposure, light exercise in the open air, a normal diet with plenty of fluids, and the relief of sleeplessness by adequate doses of a suitable sedative, preferably one of the barbiturates.The treatment of the severe case calls for strict nursing supervision in view of the impulsive suicidal tendencies sometimes displayed, and for adequate fluid intake and sedation.Glucose, 5% in saline, may be given intravenously up to 3 litres per day.If given as a drip, hexobarbitone may be added."Somnifaine " and pentobarbitone sodium are other suitable sedatives, and may be given in repeated full doses to obtain rest.A retention enema of 4 to 6 oz.(110-170 g.) of -a saturated solution of magnesium sulphate often has a quiet- ing effect when it can-be retained.Morphine is contraindicated.Machle (1935) recommends the intravenous administration of from 2 to 4 g. of magnesium sulphate in 2% solution accom- panied by doses of pentobarbitone sodium up to 15 gr.(1 g.) daily by mouth.Reference to Case 2 of this series will give *some idea of the amount of sedation which may be required in a severe case.Ample fluids should be given throughout subsequent conva- lescence to aid the elimination of lead.After a severe exposure many months may elapse before the urinary lead concentration reaches a normal figure.
Inhibition of Transplant Vasculopathy in a Rat Aortic Allograft Model After Infusion of Anti-Inflammatory Viral Serpin
Authors: Leslie W. Miller, Erbin Dai, Piers Nash, Liying Liu, Carolyn Icton, Dennis Klironomos, Lilly Fan, Patric N. Nation, Robert Zhong, Grant McFadden, Alexandra Lucas
Journal: Circulation (2000)

Transplant vasculopathy remains a difficult therapeutic problem, resulting in the majority of late cardiac graft losses. This chronic vascular disease is thought to be triggered by alloantigen-dependent and alloantigen-independent inflammatory factors. Despite improved 1-year survival, the incidence of transplant vasculopathy has not improved with current immunosuppressive protocols. Highly effective strategies have evolved in the large DNA viruses that shield infecting viruses from host inflammatory responses. Serp-1 is a secreted myxoma virus anti-inflammatory serine proteinase inhibitor. Serp-1 inhibits plasminogen activators in a manner similar to plasminogen activator inhibitor (PAI-1), a vascular protein that plays a pivotal regulatory role in vascular wound healing. In this study, we tested the ability of purified Serp-1 protein to ameliorate posttransplant vasculopathy after rat aortic allograft surgery.Serp-1 protein or controls were infused into 98 rats immediately after segmental aortic allograft transplantation. After either late (28 days, 64 rats) or early (12 to 48 hours, 24 rats) follow-up, transplanted aortic segments were harvested for morphological and immunohistochemical analysis. Significant reductions in intimal plaque growth (P<0.002) and mononuclear cell invasion (P<0.033) were detected after Serp-1 infusion at nanogram doses. Serp-1 reduced early macrophage (P<0.0016) and nonspecific lymphocyte (P<0.0179) invasion into medial and adventitial layers and inhibited associated depletion of medial smooth muscle cells (P<0.0006).Infusion of a viral anti-inflammatory serpin, Serp-1, significantly reduces early inflammatory responses and later luminal occlusion in a rat aortic allograft model.
INTERESTING CASES OF PERINEAL SECTION, WITH REMARKS.
Authors: G. FRANK LYDSTON
Journal: JAMA (1896)

During my seventeen years experience in surgical work, it has been my fortune to perform a large number of external perineal sections. Among them, as might naturally be expected, operations for serious deep strictures have preponderated. I have selected from my cases a series of the most interesting of which I have records. Some of the most interesting cases have not been recorded because of various circumstances surrounding the operations which have made it at least impracticable, if not impossible, to do so. I will first present the cases in their salient features, reserving my comments for the conclusion of the article. <h3>Case 1: Traumatic Stricture.</h3> —A lad, 15 years of age was brought to me by his parents with a history of urinary obstruction dating back one year. There was no history of gonorrhea, but of a blow upon the perineum, received some fourteen months prior to his consulting
Adverse Drug Reactions: Getting Information Back From medWatch-Reply
Authors: John D. Siegfried
Journal: JAMA (1994)

<h3>In Reply.</h3> —The experience reported by Drs Vogt and Byrns concerning their difficulty in obtaining adverse experience (AE) data from the FDA and clinically relevant details from the drug sponsors, and the frustration they express because "health care providers cannot easily access a database which could assist in managing... care" are understandable. However, they are the result of a misperception concerning the type of AE data submitted to drug sponsors and collected by theMEDWATCHprogram, and a misunderstanding of the purpose of the FDA's Voluntary Reporting System. Spontaneous AE reports that come to the drug sponsor, or to the FDA, are often incomplete and, with the exception of the small number of reports in which documented follow-up occurs, contain fragmentary data. Additionally, reports are frequently confounded by the use of concomitant medications, concurrent diseases, and the underlying medical conditions being treated. The data accumulated are not intended for case
Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes
Authors: Marc-André Wurbel, Marie Malissen, Delphine Guy-Grand, Eric Meffre, Michel C. Nussenzweig, Mireille Richelme, Alice Carrier, Bernard Malissen
Journal: Blood (2001)
Health effects of air pollutants: sulfuric acid, the old and the new.
Authors: M O Amdur
Journal: Environmental Health Perspectives (1989)

Data from exposure of experimental animals and human subjects to sulfuric acid presents a consistent picture of its toxicology. Effects on airway resistance in asthmatic subjects were well predicted by data obtained on guinea pigs. Sulfuric acid increases the irritant response to ozone in both rats and man. In donkeys, rabbits, and human subjects, sulfuric acid alters clearance of particles from the lung in a similar manner. These changes resemble those produced by cigarette smoke and could well lead to chronic bronchitis. Data obtained on guinea pigs indicate that very small amounts of sulfuric acid on the surface of ultrafine metal oxide aerosols produce functional, morphological, and biochemical pulmonary effects. Such particles are typical of those emitted from coal combustion and smelting operations. Sulfate is an unsatisfactory surrogate in existing epidemiology studies. Sulfuric acid measurement is a critical need in such studies.
Ulcerative colitis and renal cell carcinoma.
Authors: P W Plaisier
Journal: Gut (1996)

The characteristics of random samples of elderly patients (over 65 years of age), designated as consulters (n = 200) and non-consulters (n = 196), in a group general practice were compared using a postal questionnaire that was validated by comparison with findings by general practitioners in a random sample of 58 responders. A response rate of 90% was obtained, and all non-responders were visited by their general practitioner. The questionnaire had a sensitivity of 79% and a specificity of 82% when compared with general practitioner findings. The use of hospital and social services by non-consulters was low in this practice. Measures of disability and state of health showed that non-consulters were a fit group of the aged. Case finding for problems among elderly people should initially be confined to consulters, who have a high prevalence of problems. Non-consulters are a low risk group that can be assessed only with special effort and extra resources. Once an effective case finding system has been developed it might then be reasonable to consider ways of finding the few patients who have problems but do not consult their doctor.
Evaluation of the Complication Rate as a Measure of Quality of Care in Coronary Artery Bypass Graft Surgery
Authors: Jeffrey H. Silber
Journal: JAMA (1995)

To determine whether hospital rankings based on complication rates provide the same information as hospital rankings based on mortality rates.A retrospective study of in-hospital death, complication, and death following complication (failure to rescue). Hospitals were ranked using residuals based on the difference between the observed and the expected number of events (from logistic regression models); rankings were compared using Spearman rank correlations.Hospitals performing coronary artery bypass graft (CABG) surgery in the 1991 and 1992 MedisGroups National Comparative Data Bases. PATIENTS AND DATA SETS: Record abstraction data for 16,673 patients who underwent CABG procedures at 57 hospitals, linked with data from the 1991 American Hospital Association Annual Survey.After adjusting for patient admission severity of illness, there were low correlations between hospital rankings based on death or failure to rescue and those rankings based on complication (death vs complication, r = 0.07, P = .58; failure to rescue vs complication, r = -0.22, P = .11). In addition, many hospital characteristics that are generally associated with a higher quality of care were associated with higher complication rates but with expected or lower-than-expected mortality rates.Hospital rankings based on complication rates provide different information than those based on mortality rates. Until more is known about these differences, complication rates should not be used to judge hospital quality of care in CABG surgery.
Effect of low dietary lipid on the development of Sjogren's syndrome and haematological abnormalities in (NZB x NZW)F1 mice.
Authors: C.A Swanson, J.A Levy, W.J Morrow
Journal: Annals of the Rheumatic Diseases (1989)

A diet low in fat was found to retard the development of autoimmune disease in (NZB x NZW)F1 mice, whereas diets high in fat content were associated with more severe disease. The ability of a reduced lipid intake to ameliorate the progression of autoimmune disease was indicated by preserved lacrimal gland secretion (measured by a modified Schirmer test), decreased infiltration of inflammatory cells into the exocrine tissue, and decreased severity of immunohaemolytic anaemia as indicated by near-normal packed cell volume and reticulocyte values. These results suggest that nutritional intervention may be of some help in reducing the severity of pathological abnormalities associated with human systemic lupus erythematosus and Sjögren9s syndrome.
Cholecystokinin-like activity in the duodenal mucosa of duodenal ulcer patients.
Authors: S Kataoka
Journal: Gut (1982)

Cholecystokinin-like activity in the duodenal mucosa was measured by the bioassay method described by Ljungberg to elucidate its significance in 14 duodenal ulcer patients as well as in 13 normal subjects with no evidence of gastrointestinal diseases. The stage of duodenal ulceration was determined endoscopically according to the criterion of the Japanese Gastroenterological Endoscopic Society. The cholecystokinin-like activity in the duodenal mucosa of duodenal ulcer patients in active stage 1, which was considered as an early stage of active open duodenal ulceration, did not differ statistically from that of normal subjects, whereas that of duodenal ulcer patients in active stage 2 began to show a significant increase (p less than 0.05), and the cholecystokinin-like activity in the duodenal mucosa of duodenal ulcer patients in healing stage 1 or healing stage 2 was significantly higher than that in normal subjects (p less than 0.01). The cholecystokinin-like activity in the duodenal mucosa of duodenal ulcer patients in the scarring stage, however, returned to the normal range. It is concluded that cholecystokinin may act physiologically in the cure of duodenal ulcer.
Euthanasia for Minors in Belgium
Authors: Kenneth Chambaere, Marc Roelands, Luc Deliens
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Men, Women, and Bone Scintigraphy
Authors: GARY E. MEYERROSE, CHING Y. WONG, BABINGTON C. K. YUNG, SAMUEL SOSTRE
Journal: Clinical Nuclear Medicine (1994)

Three blinded observers evaluated whole-body bone scintigrams to determine the criteria that differentiate the gender of the imaged individual. The scintigraphic signs with the greatest discriminatory power were patterns of tracer uptake corresponding to male and female genitalia. Five other criteria (uterine displacement of the bladder, breast uptake of tracer, prostatic displacement of the bladder on the anterior view, chest wall attenuation, and uterine uptake of tracer) were complementary in gender discrimination. Although the most experienced observer demonstrated the greatest accuracy of gender identification on bone scintigraphy, less experienced residents also demonstrated a high degree of skill using these seven criteria.
Human seminal plasma anaphylaxis (HSPA): case report and literature review
Authors: D. G. Ebo, W. J. Stevens, C. H. Bridts, L. S. De Clerck
Journal: Allergy (1995)

Human seminal plasma anaphylaxis (HSPA) is rare but may be life-threatening. The antigen or antigens involved in these reactions reside in a glycoprotein fraction of human seminal plasma (HSP). We report a woman who experienced HSPA. Literature on the subject is reviewed.
Sickle Cell Trait—Neglected Opportunities in the Era of Genomic Medicine
Authors: Catherine Taylor, Patricia Kavanagh, Barry Zuckerman
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drugs in the Treatment of Disease; Specially Commissioned Articles from the British Medical Journal
Authors: Norman De Nosaquo
Journal: JAMA (1962)

This interesting book is packed full of much valuable information of interest to practicing physicians. It was compiled from a series of authoritative articles which were published in the British Medical Journal between 1958 and 1960 under the general heading "Drug Treatment of Disease." The articles were revised by the authors so that the information is current. They are relatively short and easy to read, and the authors do not dwell on the mechanisms of drug action involved but handle this material in a straightforward fashion without distress to the reader. They emphasize the treatment aspect of drugs; and do not gloss over the question of the toxic potential of the drugs. The articles have been grouped arbitrarily by systems for convenience. The book was designed expressly to help the practicing physician and provides him with information on new drugs and information which compares new drugs with one another and