tbuckley/cabot-search huggingface dataset:
Impact of whooping cough on patients and their families.
Authors: I D Johnston, M Hill, H R Anderson, H P Lambert
Journal: BMJ (1985)

The effects of whooping cough were studied in 21 children admitted to hospital with the disease and in their families. The illness caused considerable distress to both child and family. Parents suffered especially from fears for the life and health of their child and from serious loss of sleep. Two months after admission the child9s behaviour was still disturbed, but in most cases the rest of the family had returned to normal. There was much misunderstanding and misinformation about whooping cough among both parents and doctors.
Effect of Isoproterenol on Coronary Blood Flow in Primary Myocardial Disease
Authors: LAWRENCE D. HORWITZ, GEORGE C. CURRY, ROBERT W. PARKEY, FREDERICK J. BONTE
Journal: Circulation (1974)

At cardiac catheterization, the effect of isoproterenol on coronary blood flow was compared in six patients with primary myocardial disease and six patients who appeared to have no cardiac disease. Coronary blood flow was measured by selective coronary artery injection of xenon-133 and external monitoring of disappearance curves with a dual probe, digital scintillation counter. In the presence of similar changes in cardiac output and heart rate-systolic pressure product, changes in coronary blood flow and coronary resistance in response to isoproterenol were significantly less ( P &lt; 0.05) in the subjects with primary myocardial disease than in the normal subjects.
Response Rate Is Associated with Prolonged Survival in Patients with Advanced Non-small Cell Lung Cancer Treated with Gefitinib or Erlotinib
Authors: Kazuyuki Tsujino, Tomoya Kawaguchi, Akihito Kubo, Nana Aono, Keiko Nakao, Yasuhiro Koh, Kazunobu Tachibana, Shun-ichi Isa, Minoru Takada, Takayasu Kurata
Journal: Journal of Thoracic Oncology (2009)
MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells
Authors: Isobel S. Okoye, Stephanie M. Coomes, Victoria S. Pelly, Stephanie Czieso, Venizelos Papayannopoulos, Tanya Tolmachova, Miguel C. Seabra, Mark S. Wilson
Journal: Immunity (2014)

Foxp3+ T regulatory (Treg) cells prevent inflammatory disease but the mechanistic basis of suppression is not understood completely. Gene silencing by RNA interference can act in a cell-autonomous and non-cell-autonomous manner, providing mechanisms of intercellular regulation. Here, we demonstrate that non-cell-autonomous gene silencing, mediated by miRNA-containing exosomes, is a mechanism employed by Treg cells to suppress T-cell-mediated disease. Treg cells transferred microRNAs (miRNA) to various immune cells, including T helper 1 (Th1) cells, suppressing Th1 cell proliferation and cytokine secretion. Use of Dicer-deficient or Rab27a and Rab27b double-deficient Treg cells to disrupt miRNA biogenesis or the exosomal pathway, respectively, established a requirement for miRNAs and exosomes for Treg-cell-mediated suppression. Transcriptional analysis and miRNA inhibitor studies showed that exosome-mediated transfer of Let-7d from Treg cell to Th1 cells contributed to suppression and prevention of systemic disease. These studies reveal a mechanism of Treg-cell-mediated suppression mediated by miRNA-containing exosomes.
Constriction (banding) of Blalock--Taussig anastomosis for intractable congestive cardiac failure and pulmonary oedema
Authors: J. C. R. Lincoln, J. Stark, M. J. Tynan, E. Aberdeen
Journal: Thorax (1968)

Two young patients with complex congenital heart disease developed congestive cardiac failure and unilateral pulmonary oedema following palliative Blalock-Taussig pulmonary artery to systemic artery shunts. Following the failure of medical therapy these shunts were constricted by using braided silk ligature material, after which the heart failure and pulmonary oedema resolved.
Cellular localization of α-interferon in hepatitis B virus-infected liver tissue
Authors: Allison R. Jilbert, Christopher J. Burrell, Eric J. Gowans, Paul J. Hertzog, Anthony W. Linnane, Barrie P. Marmion
Journal: Hepatology (1986)

Cells expressing α2-interferon were identified by indirect immunofluorescence using both a polyclonal and a monoclonal anti-α-interferon antibody reagent. In hepatitis B or delta virus infection, focal clusters of α-interferon-positive infiltrating mononuclear cells and (to a lesser extent) fibroblasts were regularly seen in liver sections from patients who had chronic active hepatitis and cirrhosis and evidence of virus replication, but in a minority of patients with chronic persistent hepatitis B and not in nonvirally infected livers. This report provides evidence for local α-interferon production near the site of virus replication in hepatitis B infection, identifies mononuclear cells and fibroblasts (but not hepatocytes) as the main cell types producing interferon in this infection and suggests that locally produced α-interferon may be a natural regulator of virus replication in HBsAg-positive chronic active hepatitis. Furthermore, serological characterization of the interferon species produced locally may predict which particular interferon species could be of the greatest therapeutic benefit in specific disease states or individual patients.
Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy.
Authors: T Naseer, E M Minshall, D Y Leung, S Laberge, P Ernst, R J Martin, Q Hamid
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Interleukin-12 (IL-12) and IL-13 are two recently characterized cytokines which play an important role in the induction of T helper cell type 1 (Th1-) and Th2-like cells, respectively. Using the technique of in situ hybridization, we have investigated the expression of these cytokines in bronchial biopsies from nine allergic asthmatics and nine normal control subjects. To determine the effect of steroid therapy on the expression of IL-12 and IL-13 in asthma, the numbers of cells expressing these cytokine mRNA before and after a 1-wk course of oral prednisone in six steroid-sensitive (SS) and five steroid-resistant (SR) moderately severe asthmatics were also examined. There was an increased number of IL-13, and a decreased number of IL-12 mRNA positive cells in asthmatic subjects compared with normal control subjects (p < 0.001). After steroid treatment, the increase in FEV1 values observed in SS asthmatics was accompanied by a significant decrease in cells expressing IL-13 mRNA (p < 0.05) and an increase in the numbers of cells expressing IL-12 mRNA (p < 0.05). In contrast, steroid therapy in SR asthmatics was not associated with significant changes in IL-12 and IL-13 mRNA expression. Thus, allergic asthma is associated with a downregulation of IL-12 mRNA expression and an upregulation of IL-13 mRNA expression. These results suggest an in vivo role for IL-12 and IL-13 in modulating allergic responses and support the notion that the clinical effects of glucocorticoids are at least partially mediated through the modulation of cytokine production.
Endoscopic Retrograde Cholangiopancreaticography (ERCP) in Obstructive Jaundice Caused by Metastatic Testicular Teratoma
Authors: I. Rentsch, U. Gärtner, P. Müller, L. Kerk
Journal: Endoscopy (1977)

A 28-years-old patient with a palpable mass of two fist's size in the upper abdomen rapidly developed an obstructive jaundice. A pancreatic tumor was suspected and therefore ERCP was carried out. Unusual alterations caused by metastatic lesions of a post mortem diagnosed testicular teratoma narrowing and invading the common bile duct and displacing the main pancreatic duct were visualized.
Cardiac Replacement with a Total Artificial Heart as a Bridge to Transplantation
Authors: Jack G. Copeland, Richard G. Smith, Francisco A. Arabia, Paul E. Nolan, Gulshan K. Sethi, Pei H. Tsau, Douglas McClellan, Marvin J. Slepian
Journal: New England Journal of Medicine (2004)

The CardioWest Total Artificial Heart orthotopically replaces both native cardiac ventricles and all cardiac valves, thus eliminating problems commonly seen in the bridge to transplantation with left ventricular and biventricular assist devices, such as right heart failure, valvular regurgitation, cardiac arrhythmias, ventricular clots, intraventricular communications, and low blood flows.We conducted a nonrandomized, prospective study in five centers with the use of historical controls. The purpose was to assess the safety and efficacy of the CardioWest Total Artificial Heart in transplant-eligible patients at risk for imminent death from irreversible biventricular cardiac failure. The primary end points included the rates of survival to heart transplantation and of survival after transplantation.Eighty-one patients received the artificial-heart device. The rate of survival to transplantation was 79 percent (95 percent confidence interval, 68 to 87 percent). Of the 35 control patients who met the same entry criteria but did not receive the artificial heart, 46 percent survived to transplantation (P<0.001). Overall, the one-year survival rate among the patients who received the artificial heart was 70 percent, as compared with 31 percent among the controls (P<0.001). One-year and five-year survival rates after transplantation among patients who had received a total artificial heart as a bridge to transplantation were 86 and 64 percent.Implantation of the total artificial heart improved the rate of survival to cardiac transplantation and survival after transplantation. This device prevents death in critically ill patients who have irreversible biventricular failure and are candidates for cardiac transplantation.
DURATION OF MEDITERRANEAN FEVER
Authors: P. W. Bassett-Smith
Journal: BMJ (1903)

MEMORANDA.1M589.and there has been no recurrence of any kind ; the scar is smooth, level with the surrounding skin, soft and supple, and, except that it is whiter than the rest of the nose, is almost imperceptible.CASE II.Male aged 5o.Growth in the skin over the mastoid bone behind the lobule of the right car.The first trouble was noticed a year ago, wlhen a small pimple or wart appeared which used to catch the razor in shaving.Now, January, 1902, there is a thickenied patch in the skin five-eighths of an inch lonig by half an inch in breadth.The patch seems to be about onie-eightlh of an inch thick, is slightly raised above the surroundiing skiin, and feels semilicartilaginous not unlike the
295. Adeno-Associated Virus-Mediated Transfer of the Genes Encoding Cryptic Kringle Fragments of Apolipoprotein (A) Suppresses Tumor Growth and Metastasis In Vivo
Authors: Kyuhyun Lee, Sung-Tae Yun, Eui-Cheol Jo
Journal: Molecular Therapy (2005)

Vectors derived from adeno-associated virus (AAV) have a prominent property that ensures long-term gene expression at a single administration, which may be of paramount importance for the success of anti-angiogenic anti-tumor therapy. Previous studies have demonstrated the anti-angiogenic activities of apolipoprotein (a) (apo (a)) both in vitro and in vivo, and further elucidated a potential anti-angiogenic and anti-tumor activity of cryptic kringle fragments derived from apo(a) (LKs). In our present study, we generated recombinant AAV carrying genes encoding LKs (rAAV-LKs), and observed ample expression of LKs on both transient transfection and infection of HEK 293 cells with the vector plasmid pAAV-LKs and rAAV-LKs respectively, as identified by Western blot analysis and ELISA. The LK-containing supernatant inhibited proliferation of human vascular endothelial cells, which supported the unique activity of LKs as anti-angiogenic molecules in vitro. Intramuscular administration of rAAV-LKs substantially reduced the number of tumor nodules in both the pulmonary and the hepatic metastasis models in the immuno-deficient mice, and also gave substantial suppression of tumor growth in mice bearing subcutaneously transplanted hepatocellular carcinoma cells of Huh-7 and Hep3B, respectively. The median survival of rAAV-LK treated mice bearing tumors of Huh-7 was significantly higher (p<0.077) than from control groups, and 30% of the mice were rescued from tumor, as judged by the H and E-stained histochemical analysis. All together, these results suggested that rAAV-LKs hold potential for a gene therapeutic agent that may ensure long-term anti-angiogenic anti-tumor activity in vivo.
Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro
Authors: K. Katsuoka, H. Schell, O.P. Hornstein, B. Wessel
Journal: British Journal of Dermatology (1987)

Journal Article Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro Get access K. Katsuoka, K. Katsuoka Department of Dermatology, University of Erlangen‐Nuernberg, Hartmannstrasse 14, D‐8520 Erlangen, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar H. Schell, H. Schell Department of Dermatology, University of Erlangen‐Nuernberg, Hartmannstrasse 14, D‐8520 Erlangen, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar O.P. Hornstein, O.P. Hornstein Department of Dermatology, University of Erlangen‐Nuernberg, Hartmannstrasse 14, D‐8520 Erlangen, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar B. Wessel B. Wessel Department of Dermatology, University of Erlangen‐Nuernberg, Hartmannstrasse 14, D‐8520 Erlangen, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 3, 1 March 1987, Pages 464–465, https://doi.org/10.1111/j.1365-2133.1987.tb05861.x Published: 01 March 1987
Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy
Authors: Sergio Mezzano, Alejandra Droguett, M. Eugenia Burgos, Leopoldo G. Ardiles, Claudio A. Flores, Claudio A. Aros, Italo Caorsi, Carlos P. Vío, Marta Ruiz-Ortega, Jesús Egido
Journal: Kidney International (2003)
Modulating Angiogenesis
Authors: Shiladitya Sengupta, Sue-Anne Toh, Lynda A. Sellers, Jeremy N. Skepper, Pieter Koolwijk, Hi Wun Leung, Hin-Wing Yeung, Ricky N.S. Wong, Ram Sasisekharan, Tai-Ping D. Fan
Journal: Circulation (2004)

Ginseng is a commonly used nutraceutical. Intriguingly, existing literature reports both wound-healing and antitumor effects of ginseng extract through opposing activities on the vascular system. To elucidate this perplexity, we merged a chemical fingerprinting approach with a deconstructional study of the effects of pure molecules from ginseng extract on angiogenesis.A mass spectrometric compositional analysis of American, Chinese and Korean, and Sanqi ginseng revealed distinct "sterol ginsenoside" fingerprints, especially in the ratio between a triol, Rg1, and a diol, Rb1, the 2 most prevalent constituents. Using a Matrigel implant model and reconstituting the extracts using distinct ratios of the 2 ginsenosides, we demonstrate that the dominance of Rg1 leads to angiogenesis, whereas Rb1 exerts an opposing effect. Rg1 also promoted functional neovascularization into a polymer scaffold in vivo and the proliferation of, chemoinvasion of, and tubulogenesis by endothelial cells in vitro, an effect mediated through the expression of nitric oxide synthase and the phosphatidylinositol-3 kinase-->Akt pathway. In contrast, Rb1 inhibited the earliest step in angiogenesis, the chemoinvasion of endothelial cells.The present study explains, for the first time, the ambiguity about the effects of ginseng in vascular pathophysiology based on the existence of opposing active principles in the extract. We also unraveled a speciogeographic variation impinging on the compositional fingerprint that may modulate the final phenotype. This emphasizes the need for regulations standardizing herbal therapy, currently under the Dietary Supplement and Health Education Act. Furthermore, we propose that Rg1 could be a prototype for a novel group of nonpeptide molecules that can induce therapeutic angiogenesis, such as in wound healing.
DIETARY EFFECTS ON ANEMIA PLUS HYPOPROTEINEMIA IN DOGS
Authors: F. S. Robscheit-Robbins, G. H. Whipple
Journal: The Journal of Experimental Medicine (1949)

Casein (purified or commercial) in this type of experiment falls in the top bracket as a protein consistently favorable for maximal new hemoglobin and plasma protein production in doubly depleted dogs (anemic and hypo-proteinemic). Lactalbumin is less favorable for total blood protein production and the ratio of plasma protein to hemoglobin is high-that is lactalbumin favors plasma protein production as compared with casein, or is less favorable for hemoglobin production. Peanut flour (purified or commercial) is less than half as effective as casein in promoting new blood protein production. The ratio of plasma protein to hemoglobin is about the same as casein. Wheat gluten as tested is distasteful to dogs. It is neither very good nor very poor for blood protein production when it is eaten. There is nothing unusual about the response. Weight loss usually confuses the picture. Liver stands as a control base line for the above experiments. Its capacity to further hemoglobin and plasma protein production is well established. The production of hemoglobin was about 3 times that of plasma protein in the experiments.
Intrapancreatic Accessory Spleen Detected by 68Ga DOTANOC PET/CT and 99mTc-Colloid SPECT/CT Scintigraphy
Authors: Angela Collarino, Annemilia del Ciello, Germano Perotti, Vittoria Rufini
Journal: Clinical Nuclear Medicine (2014)

A 77-year-old man was referred to our center for a suspected neuroendocrine neoplasm in the pancreatic tail, incidentally detected at CT. Ga DOTANOC PET/CT showed intense tracer uptake in the pancreatic lesion. At MRI, the lesion was similar to the spleen on all sequences, suggesting the presence of intrapancreatic accessory spleen. A Tc-colloid SPECT/CT scan performed to differentiate spleen tissue from neuroendocrine tumor revealed a focal uptake in the pancreatic lesion, thus confirming the presence of ectopic spleen and avoiding unnecessary surgery.
Chlorinated Aromatic Hydrocarbon Induced Modifications of the Hepatic Endoplasmic Reticulum: Concentric Membrane Arrays
Authors: D. H. Norback, J. R. Allen
Journal: Environmental Health Perspectives (1972)

A number of commercial compounds having chlorinated aromatic hydrocarbon structures are used extensively for medical(3), industrial(4) and agricultural(5) purposes.Quantities of certain parent chlorinated aromatic hydrocarbons and metabolites have been repeatedly detected as residues in the food supply and tissues of birds, fish, and mammals(6-9) including man(10).Chlor- inated diphenyl-p-dioxins have been identified as contaminants of many commercial products, such as certain edible fats, herbicides and disinfectants.> It is suggested that the compound results from the conjugation of commercial chlorinated phenols(1l).Polychlorinated polyphenyls are among the most abundant chlorinated hydrocarbon global pollutants.Their contamination of the environment is a result of the widespread commercial use of these compounds for their properties of insulation, adhesiveness, thermoplasticity, chemical inertness, and insolubility.Following this investigation of sequential bio- chemical and ultrastructural alterations within the liver produced by three chlorinated aromatic hydrocarbonschlorinated diphenyl-p-dioxin, polychlorinated biphenyls (PCBs), and a highly chlorinated triphenyl (PCT)-certain similarities of biochemical and ultrastructural effects of the compounds were observed.The livers of rats fed the chlorinated aromatic hydrocarbons consis- tently contained numerous multi-layered concen- tric membrane arrays, proliferated smooth
'More!' Cry Children as Congress Shakes Its Head
Authors: Andrew A. Skolnick
Journal: JAMA (1995)

WHILE CONGRESS is preparing legislation that would seriously cut funding for federal food assistance programs, a newly completed study shows that some 4 million children younger than 12 years in the United States go hungry during at least part of the year. Almost 10 million additional children in low-income families are at risk of hunger and its farreaching health and psychosocial consequences. The findings of the 3-year, nationwide survey were released by the Food Research and Action Center, Washington, DC, a private, national not-for-profit organization dedicated to eliminating hunger and undernutrition in the United States. According to the center, its study, called the Community Childhood Hunger Identification Project, is the most rigorous and comprehensive investigation of childhood hunger in the United States carried out to date. "The study rigorously documents what people at the front lines have been saying for years— hunger is a problem among the nation's low-income families,"
Evolution of an Examination: M.R.C.P. (U.K.)
Authors: P. R. Fleming, W. G. Manderson, M. B. Matthews, P. H. Sanderson, J. F. Stokes
Journal: BMJ (1974)

Recent changes in the structure of the examination for M.R.C.P. (U.K.) have prompted a review of these together with a historical outline of the examinations which preceded it at the Royal Colleges of Physicians of Edinburgh, Glasgow, and London. Part I of the examination continues to fulfil its role as a screen and a slight change in the marking system appears to have improved its discriminating powers still further. The major change in part II is the substitution of a more objective written test in place of the essay papers.
Radiopharmaceutical Options for the Ventilation Part of Ventilation-Perfusion Scintigraphy Performed for the Indication of Pulmonary Embolism
Authors: Adam Opanowski, Lucas J. Gross, Mark Tulchinsky
Journal: Clinical Nuclear Medicine (2015)

This US survey aimed to determine (1) relative utilization of the 2 techniques, a gas radiopharmaceutical technique (GRT) versus aerosolized radiopharmaceutical technique (ART), in ventilation-perfusion scintigraphy done for pulmonary embolism indication and (2) radiopharmaceuticals (RFs) used.Nuclear medicine physicians and technologists were sent a questionnaire asking which RF(s) their imaging facilities are using for ventilation imaging. Respondents were classified as reporting from academic/teaching facilities (ATFs) or from community-based facilities (CBFs).Of the 256 surveyed, 78 responded (30.5%), who reported about 158 facilities. Majority (90/158, 57%) were CBFs, whereas the rest (68/158, 43%) were ATFs. Overall, slight majority (92/158, 58%) used ART, 90 using (99m)Tc-DTPA, one using (99m)Tc-sulfur colloid (SC), and one using (99m)Tc-PYP. Minority (66/158, 42%) used GRT (all ¹³³Xe). In the CBFs, a slight majority (55/90, 61%) used ART (including one that used (99m)Tc-PYP), whereas the rest 35 (39%) of 90 used GRT. In the ATFs, a slight majority (37/68, 54.4%) used ART (including 1 facility that used (99m)Tc-SC), whereas the rest (31/68, 45.6%) used GRT. There was no statistically significant difference in ART:GRT ratios between CBFs and ATFs (P = 0.35).Aerosolized RF technique is overall more common (57%) than GRT, about the same at CBFs and at ATFs, and almost all ART using (99m)Tc-DTPA. Therefore, (99m)Tc-DTPA price increase would have impacted a significant number of the US facilities, which should increase interest in alternatives identified by this survey—(99m)Tc-SC and (99m)Tc-PYP.
When Is Critical Illness Not Like an Asteroid Strike?
Authors: Theodore J. Iwashyna, Hallie C. Prescott
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

For some time now, critical care research has had a dirty secret, albeit not one well kept. Our epidemiologic work was most feasible if we prospectively collected data after patients had already declared themselves to be critically ill. Our animal models were most feasible if we took healthy young mammals and then, at a time convenient for us, ligated and punctured their cecum or instilled bacteria into their trachea.