tbuckley/cabot-search huggingface dataset:
A Study of Fifty Cases Treated by Flavine
Authors: E. F. Bashford, J. N. J. Hartley, J. T. Morrison
Journal: BMJ (1917)

SINCE the beginning of June one of our wards has been devoted to an.investigation of tlhe clinical results of the application of flavine to war wounds.At the same time an attenmpt lhas been made to interpret these restults with the help of histological and bacteriological methods.The flavine used lhas been for the most part " 1 acriflavine " s-ent out by the Medical Research Committee, but latterly samples of proflavine from the same soutrce were substi- ,tuted.The results were suLbstantially the same wvith both.TE:CHNIQUE.Thle primlary object of tlle worlk being to confirm tlle good results claimned by the earliest workers with flavine, we made a point of adleriing as closely as possible to tlhe lines of treatment laid down by them-.Tihe skin was careftully cleaned -ith neutral sodium oleate solution and covered witlh sterile strips of bandage cloth permeated *ithT steiiized vaseline, the wountid was swabbed out witlh gauze wrung liglhtly ou't with flavine, all obvious necrofic tissue Cut cleanly away, and every recess tlhen packed withi strips of da-essing soakeed with flavine solution (1: 1,000).As far as possible lint was used for the dressing, on the ground that it retains within -its meslh a inielh larger quantity of the fluiid it is desired to apply to tlle wound surface tlhan gauze, but it was fouLnnd that in small or irregular cavities pieces of gauze are often more convdnient.In a few cases, whe-le long tracks or ,pockets difficult of access had to be dealt with, Carrel's tuibes were used for the purpose of a four-hourly instilla- tion of the flavine s'olution, 10 c.cm. per tube.The flavinie solution was used throughlout at tlle original strength of 1: 1,000, although we notice that certain work-ers in France 2 'suggest that after a few days it is advisable to dilute it down to 1: 5,000.Tlle last step in the dressing was to apply an impe^i-meable covering.For this pturpose one or two thicknesses of the bandage cloth soaked in vaseline.already referred to, were used.Needless to Say, carefui splinting and renmoval of foreign bodies was carricd out 'where necessary.TYPES or CASES DFALT WVITI.On accoult of the experimental nattre of tlhe treatmuent, thle cases were carefullv arranged in a series of gradually increasing severity.Tihe wounds, taken as a whiole, were not of great gravity, and this fact should be remembered in estimating thie value of the treatment.Almost all lhad been treated previously at t'he front by the Carrel-Dakin mlethlod witliin twenty-four hours; of being wouinded, and, in tlle nmajority of instances, very efficiently.No wounds involving tlle cavities of the Lead, chest, or abdomen were included.METHoI) OF INVESTICATIONN.
Myxoedema coma induced by beta-adrenoreceptor-blocking agent.
Authors: K Murakami, T Kasama, R Hayashi, M Tsushima, Y Nishioheda, H Koh, S Nambu, M Ikeda
Journal: BMJ (1982)

are similar regulations in many parts of the USA, Canada, and South Africa.No such legislation exists in this country; it has been stated that the number of deaths is comparatively small and that it is difficult to justify safety regulations that affect private property.Accidents that leave a child dead or severely handicapped, however, are a tragedy, particularly when they most probably could have been prevented by simple safety measures.Although these deaths are a relatively small proportion of the 50 or so children aged under 5 who are drowned each year,5 they are preventable; it is surely not unreasonable, therefore, to require the owners of swimming pools, who are usually relatively wealthy, to ensure that they are safely enclosed.We thank Mr R Ferguson of the Home Office and Mrs J Burton of the medical statistics unit, Office of Population Censuses and Surveys, for their help.The analysis and conclusions described in this article, however, are ours alone.
Thrombocytopenia in Homosexual Men
Authors: FRED P. ROSENFELT
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 June 1987Thrombocytopenia in Homosexual MenFRED P. ROSENFELT, M.D., BARRY E. ROSENBLOOM, M.D., IRWIN M. WEINSTEIN, M.D.FRED P. ROSENFELT, M.D.Search for more papers by this author, BARRY E. ROSENBLOOM, M.D.Search for more papers by this author, IRWIN M. WEINSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-6-911_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The exact risk for the acquired immunodeficiency syndrome (AIDS) in thrombocytopenic homosexual men seropositive for the human immunodeficiency virus (HIV) is uncertain. Holzman and colleagues (1) report that thrombocytopenia does not increase the incidence of AIDS in homosexual men from New York exposed to HIV. We have previously described AIDS in a group of homosexual men with immune thrombocytopenia purpura in our Los Angeles community practice (2).We have treated 12 homosexual men for immune thrombocytopenia purpura. They have been observed for 3 months to 4 years with 1 patient lost to follow-up. Bleeding, purpura, or asymptomatic...References1. HOLZMANWALSHKARPATKIN RCS. Risk for the acquired immunodeficiency syndrome among thrombocytopenic and nonthrombocytopenic homosexual men seropositive for the human immunodeficiency virus. Ann Intern Med. 1987;106:383-6. LinkGoogle Scholar2. ROSENFELTROSENBLOOMWEINSTEIN FBI. Immune thrombocytopenia in homosexual men [Letter]. Ann Intern Med. 1986;104:583. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 8635 West Third Street; Los Angeles, CA 90048 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuelles sérologies virales demanderdans le purpura thrombopénique immunologique chez le sujet non infecté par le virus de l'immunodéficience humaine? 1 June 1987Volume 106, Issue 6Page: 911-912KeywordsAIDSHIVHemorrhageHomosexualsIdiopathic thrombocytopenic purpura Issue Published: 1 June 1987 PDF downloadLoading ...
Maintenance of High Sickling Rate in an African Community
Authors: H. Lehmann, A. B. Raper
Journal: BMJ (1956)

In 1973-4 nearly 10 000 Montreal drivers, interviewed by telephone, provided information about medical and associated factors and about driving habits, in particular annual mileage. Records of accidents suffered by these drivers in the Province of Quebec over 39 months (1973-6) were also collected. The 7634 current drivers, with appropriate permits, and all of whose data passed reliability edits, were placed into nine sets-that is, three classes: women; men with the usual permit; and men with a chauffeur9s permit to drive taxis, heavy vehicles, etc; further subdivided into three age groups. Accident rates depended on mileage, but after allowance for differences in mileage, accident rates still varied with sex, type of permit, and age. No association of the risk of accidents and a medical or related factor was consistent over all nine sets of drivers. Of the 7634 drivers, 347 had had at least one accident causing injury or death in the 39 months from 1 January 1973. These "cases" were compared with 347 "referents," closely matched for sex, type of permit, age, and reported mileage, but without accident causing injury or death. Cases included higher proportion who worked irregular shifts, who were overweight, and who reported smoking while driving. Relative to the chance of a referent suffering any accident in the 39-month period, a case had at least double the risk of having an accident in addition to the index accident.
ACTH and Cortisone Therapy of Rheumatic Fever and Rheumatic Carditis
Authors: Benedict F. Massell
Journal: New England Journal of Medicine (1954)

The apparent usefulness of cortisone and ACTH in the treatment of acute rheumatic fever and rheumatic carditis was first pointed out by Hench and his associates1 shortly after they had reported the remarkable suppressive effect of these hormones on rheumatoid arthritis.2 , 3 Since that time a number of investigators, expressing a variety of opinions, have presented articles dealing with this subject. Some4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 have confirmed Hench's findings, and, although most of these investigators believe that more work needs to be done before the therapeutic value of the hormones can be completely defined, they have interpreted their observations as either suggesting or as . . .
Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.
Authors: N Ho, M Gullberg, T Chatila
Journal: The Journal of Experimental Medicine (1996)

The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein. CaMKIV/ Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin. AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells. We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells. These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.
THE IMPORTANCE OF AURAL ANATOMY IN ROUTINE CLINICAL WORK.
Authors: B. ALEX. RANDALL
Journal: JAMA (1895)

That the aural surgeon must have the topography of the ear and the surroundings clear in his mind and ready at his finger ends, when operating on the mastoid or still more within the tympanum, is evident to all. He must be thus posted, or wholly belie his status as a specialist. Yet it is no less true that the practitioner who would well treat, topically, the routine cases, still more attempt paracentesis as most of the text-books advise, must know the variations in the configuration of the external auditory canal, the size, depth and inclination of the drum-head and the structures which lie beyond it within easy reach of damage by his manipulations. Unfortunately, much experience in post-graduate teaching shows that the majority of men of some otologic experience reveal serious defects in this direction; and do some very bungling work, however posted in the theory; not so much
Treatment of a Marrow Stem-Cell Disorder with Granulocyte Colony-Stimulating Factor
Authors: Peter J. Quesenberry
Journal: New England Journal of Medicine (1989)

Marrow stem cells are driven by a number of regulators, termed colony-stimulating factors or interleukins. Traditionally, the marrow stem cell has been defined by its capacity to renew itself and to differentiate into several types of blood cells. Perhaps an equally valid definition of these cells can be based on their responsiveness to growth factor. The study reported by Hammond and colleagues in this issue of the Journal 1 shows that one of the hematopoietic colony-stimulating factors, granulocyte colony-stimulating factor (G-CSF), is clinically beneficial in the disease cyclic hematopoiesis. G-CSF is typical of many of the other lymphohematopoietic growth factors, in . . .
Renal transplantation. Effect on the ischemic heart disease of essential malignant hypertension
Authors: J. F. Mahony
Journal: JAMA (1976)

In 14 of 204 consecutive cadaveric renal allograft recipients, the primary diagnosis was essential hypertension. Four patients had manifest ischemic heart disease before transplantation. Three of these patients died within 31 months of transplantation from recurrent myocardial infarction, and the fourth experienced coronary insufficiency. Cadaveric renal transplantation does not prevent the progression of coronary artery disease in patients whose renal failure was due to essential hypertension. In the presence of angina or previous myocardial infarction, these patients may be better treated by maintenance hemodialysis. (<i>JAMA</i>235:2318-2320, 1976)
SARCOMA OF THE STOMACH.
Authors: GEORGE DOCK
Journal: JAMA (1900)

T. J. W., a male, married, merchant, 55 years old, was admitted to the University Hospital Jan. 18, 1900, on account of loss of strength and weight, and distention, burning pain and tumor in the region of the stomach. The family history is negative. In early life, he had whooping-cough and measles, and while in the army during the Civil War, he had several attacks of intermittent fever, and was jaundiced four months. Ever since then he has been constipated. Up to two years ago he had every summer an attack of pain in the abdomen, with vomiting, fever, pain in the head and back, ending with diarrhea, but he has never had jaundice after these attacks. During the last four years, he was postmaster and had long hours. He ate hurriedly and heartily, almost without mastication; and thinks that this has aggravated his present disease. He uses tea and
Trust hospital criticised for privatising pathology services
Authors: S Kingman
Journal: BMJ (1994)

An NHS trust hospital that is about to privatise its pathology service has been reported to the district auditor by the British Medical Association (BMA), which wants an investigation into the way the trust conducted the tendering process. In a separate move the Royal College of Pathologists has said that it fears that the quality of the service could suffer if the privatisation goes ahead. North Hertfordshire NHS Trust said last October that it was awarding the contract for pathology services at the Lister Hospital in Stevenage to United Laboratories.

Bob Ewings, chief executive of the trust, rejected the college's criticism that the quality of the service could suffer with independent management. “The service could suffer if the trust does not manage it properly. But we will have in place proper systems and proper structures to make sure that does not happen.”

The contract is one of the first to be given to an independent company for pathology services in the NHS. It comes in advance of a review of pathology services by the Department of Health, due later this year, which will produce guidelines for developing “high quality, cost effective services responsive to the needs of patients and users.”

Doctors' leaders fear that pathology is one of many clinical specialties that could be privatised and are worried that the quality of patient care could suffer. Dr Sandy Macara, chairman of the BMA's council, said: “We are concerned …
Loss of Rb1 by epigenetic modification regulates expansion of MDSC in cancer
Authors: Je-In Youn, Kyungwha Lee, Hai-Chon Lee, Dmitry I Gabrilovich
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells with potent immune suppressive activity in cancer and many other pathologic conditions. MDSCs consist of two major subsets: monocytic MDSCs (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs). Each subset of
The Value of Left Parasternal Impulse Recordings in the Assessment of Mitral Regurgitation
Authors: LOTFY L. BASTA, PAUL WOLFSON, DWAIN L. ECKBERG, FRANCOIS M. ABBOUD
Journal: Circulation (1973)

Left parasternal cardiograms were recorded at the fifth intercostal space in 30 patients with mitral regurgitation. Early systolic outward movements (E), late systolic outward movements (LOM), and the ratio of the LOM area to the total area occupied by the left parasternal cardiogram (LPC area) were examined. Thirteen patients had pure mitral regurgitation due to ruptured chordae tendineae (ten patients) or "floppy mitral valve" (three patients). In these patients LOM/E correlated significantly with the regurgitation volume determined by the difference between angiographic and Fick stroke volumes, ( r = 0.93, P &lt; 0.01), and with the height of the "v" wave in the pulmonary artery wedge pressure tracings ( r = 0.79; P &lt; 0.01). Simultaneous recordings of left parasternal movements and pulmonary wedge pressures in eight patients in this group showed a close relationship between LOM and "v" waves. Fourteen patients had rheumatic heart disease and mitral regurgitation associated with mitral stenosis of varying degrees of severity. In this group there was no significant correlation between LOM/E or LOM area/LPC area and the regurgitation volume or the height of the "v" wave. Of three patients who had congenital atrial septal defect in addition to mitral regurgitation, none had prominent LOM in the left parasternal cardiogram. This study suggests that if mitral stenosis and atrial septal defect can be excluded on clinical evidence, the left parasternal cardiogram may be used to obtain a noninvasive assessment of the severity of mitral regurgitation, particularly in patients with recent onset of the disease.
Exposure to heterocyclic amines.
Authors: K Wakabayashi, H Ushiyama, M Takahashi, H Nukaya, S B Kim, M Hirose, M Ochiai, T Sugimura, M Nagao
Journal: Environmental Health Perspectives (1993)

Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was highest (0.56-69.2 ng/g), that of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was second highest (0.64-6.44 ng/g), and those of other HAs were 0.03-2.50 ng/g. Heterocyclic amines were found in urine samples of 10 healthy volunteers consuming a normal diet, but HAs were not detectable in urine samples of three patients receiving parenteral alimentation. These results strongly suggest that humans are continuously exposed to HAs derived from food in the normal diet. Based on quantitative data on the levels of HAs in cooked foods and urine samples, the daily exposures to PhIP and MeIQx were estimated to be 0.1-13.8 micrograms and 0.2-2.6 micrograms per person, respectively. These levels of carcinogenic HAs are in the same range as those of other carcinogens such as N-nitrosodimethylamine and benzo[a]pyrene to which humans are exposed.
PRKDC mutations in a SCID patient with profound neurological abnormalities
Authors: Lisa Woodbine, Jessica A. Neal, Nanda-Kumar Sasi, Mayuko Shimada, Karen Deem, Helen Coleman, William B. Dobyns, Tomoo Ogi, Katheryn Meek, E. Graham Davies, Penny A. Jeggo
Journal: Journal of Clinical Investigation (2013)

The DNA-dependent protein kinase catalytic subunit (DNA-PKcs; encoded by PRKDC) functions in DNA non-homologous end-joining (NHEJ), the major DNA double strand break (DSB) rejoining pathway. NHEJ also functions during lymphocyte development, joining V(D)J recombination intermediates during antigen receptor gene assembly. Here, we describe a patient with compound heterozygous mutations in PRKDC, low DNA-PKcs expression, barely detectable DNA-PK kinase activity, and impaired DSB repair. In a heterologous expression system, we found that one of the PRKDC mutations inactivated DNA-PKcs, while the other resulted in dramatically diminished but detectable residual function. The patient suffered SCID with reduced or absent T and B cells, as predicted from PRKDC-deficient animal models. Unexpectedly, the patient was also dysmorphic; showed severe growth failure, microcephaly, and seizures; and had profound, globally impaired neurological function. MRI scans revealed microcephaly-associated cortical and hippocampal dysplasia and progressive atrophy over 2 years of life. These neurological features were markedly more severe than those observed in patients with deficiencies in other NHEJ proteins. Although loss of DNA-PKcs in mice, dogs, and horses was previously shown not to impair neuronal development, our findings demonstrate a stringent requirement for DNA-PKcs during human neuronal development and suggest that high DNA-PK protein expression is required to sustain efficient pre- and postnatal neurogenesis.
Dapsone in Thrombocytopenia of the Antiphospholipid Antibody Syndrome
Authors: Arthur Kavanaugh
Journal: Annals of Internal Medicine (1995)

Letters15 May 1995Dapsone in Thrombocytopenia of the Antiphospholipid Antibody SyndromeArthur KavanaughArthur KavanaughSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-10-199505150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Lesprit and colleagues report the potential steroid-sparing effect of dapsone for the treatment of thrombocytopenia in a patient with the antiphospholipid antibody syndrome. As with danazol, dapsone has also previously been used successfully to treat idiopathic immune thrombocytopenia. Although the mechanisms underlying thrombocytopenia in these two conditions may differ, several therapies that have been successful in treating idiopathic immune thrombocytopenia might be useful in treating thrombocytopenia associated with antiphospholipid antibodies. Expanding the scope of potential therapies for this disorder could provide substantial benefits to affected patients by modifying the risks associated with prolonged use of corticosteroids. Author, Article, and Disclosure InformationAuthors: Arthur Kavanaugh PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1995Volume 122, Issue 10 Page: 802 Keywords Antibodies Antibody production Antiphospholipid syndrome Corticosteroid therapy Idiopathic thrombocytopenic purpura ePublished: 15 August 2000 Issue Published: 15 May 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Bone Scan That Saved a Laparotomy
Authors: MOHANLAL C. MAKHIJA, SIDNEY SCHULTZ
Journal: Clinical Nuclear Medicine (1983)

The role of computerized blood flow analysis in routine bone scanning is reviewed. Cases illustrating the technique include proven diagnoses of toxic synovitis, Legg-Perthes disease, arthritis, avascular necrosis of the hip, fractures, benign and malignant tumors, Paget's disease, cellulitis, osteomyelitis, and shin splints. Several examples also show the use of the technique in monitoring treatment. The use of quantitative data from the blood flow, bone uptake phase, and static images suggests specific diagnostic patterns for each of the diseases presented in this atlas. Thus, this technique enables increased accuracy in the interpretation of the radionuclide bone scan.