tbuckley/cabot-search huggingface dataset:
Abstract P6-14-14: Concerted Anti-Tumor/Radiosentizing Effect of Epigallocatechin Gallate, Resveratrol and Genistein by Targeting Tumor Invasion and Metastasis Molecules in Human Breast Cancer Cells
Authors: J Veeraraghavan, K Kardokus, M Natarajan, S Aravindan, TS Herman, N. Aravindan
Journal: Cancer Research (2010)

Abstract Accomplishing the desired anti-tumor efficacy with individual dietary phytochemicals is clinically unachievable. This is due to the existence of converging and diverging pathways spanning the complex metabolic networks in cancer cells. This complexity demands the development of a multi-component approach with physiological doses of phytochemicals that could be used as “deliverable” anti-cancer agent. To address this concern, we investigated the synergistic efficacy of Genistein (GEN), Epigallocatechin gallate (EGCG) and Resveratrol (RES) in mitigating cancer progression. Human breast adenocarcinoma cells (MCF-7 and MDA-MB-231) were treated with physiological concentration of GEN, EGCG, RES, individually or all three together (GER). In parallel cultures cells were treated with GER and either exposed to radiation (2Gy;IR) or treated with β-estradiol (≥2E, positive control). The trated cells were examined after 24h. In MCF-7 cells, QPCR profiling of 93 tumor invasion and metastasis molecules revealed that EGCG, RES and GEN significantly (≥2 fold) induced 23, 36, 22 genes and completely suppressed 61, 40 and 64 genes respectively as stand-alone compounds. Conversely, GER completely knocked down the transcription of 82 genes, while another 9 genes were maintained at baseline level. More importantly, GER significantly inhibited 75 and 63 genes in ≥2E and IR exposed MCF-7 cells. Interestingly, in highly metastatic MDA-MB-231 cells, EGCG, RES, GEN significantly induced 17, 19, 2 genes and completely suppressed 41, 26 and 57 genes respectively as stand-alone compounds. Conversely, GER completely suppressed 67 genes while another 17 genes were maintained at baseline level. To that end, GER significantly inhibited 57 and 59 genes and maintained 16 genes at basal level in ≥2E and IR exposed MCF-7 cells. Taken together, these data evidently exhibit the potential synergestic effect of EGCG, GEN and RES in mitigating breast cancer progression as opposed to their stand alone effect. More importantly, these data strongly suggests that GER potentiates synergistic radiosensitization in these cells and this GER influenced radiosensitization may involve selective targeting of tumor invasion and metastatic transcription. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-14-14.
The role of folk games in fitness development
Authors: Ashok Kumar Nayak, Pranakrishna Rout
Journal: British Journal of Sports Medicine (2010)

Youth who lacked in physical courage, fitness and skill were a danger to the community. It is a known fact that the present youth is very sportive. It is his general tendency to participate in different games and sports, which give him maximum pleasure, spontaneity and recognition. Apart from modern games and sports, the folk games also play an unique role in social reconstruction, prosperity for development of culture of the society and self. Folk games like Baguddi, Hu tu tu, Bohuchori, Gambhadian (folk games of Odisha) develop better physical fitness and can be compared with modern physical activities. This study was conducted on 50 rural male youths of Nayagarh district of Orissa State; all subjects were selected on random basis. The age of these subjects ranged between 18 and 22 years. The subjects were divided into two groups (experimental and control group). Twelve week training on Gambhandian (a folk activity conducted during Rakshya Bhandan in Orissa) was administered to the entire group with 30 min duration in the morning and evening 6 days a week. The pre- and post-test scores were taken and compared with Sargent's vertical jump. To find out the effect of the training programme the data was treated by applying analysis of co-variance and level of confidence was chosen at 0.05. Result of the study revealed that the experimental group on Gambhadian training programme can develop explosive power to increase jumping ability of an athlete.
Ulcers and Gastritis
Authors: W. K. Leung, F. K. Chan, D. Y. Graham
Journal: Endoscopy (2006)

Gastric cancer is still the second commonest cause of cancer-related death in the world. Helicobacter pylori is now thought to be responsible for more than 95 % of gastric cancers. However, the prevalence of gastric cancer varies with age, within and between populations and regions, and between the sexes. The natural history of the disease and the risk factors for developing gastric cancer are still poorly defined.
Parity and breast cancer.
Authors: M Alderson
Journal: BMJ (1981)

Data from the 1961 and 1971 Censuses in England and Wales were used to estimate the age distribution of women of various parities in 1976. Applying the age-specific incidences of breast cancer for women in England and Wales in 1975 gave the expected number of cases of that disease in 1976 and permitted an estimate of the mean age at diagnosis of breast cancer at each parity. This showed that the highest average age for breast cancer occurred in nulliparous women (65.9 years) and that the lowest age for the disease occurred in women who had borne two children (60.4 years). The figures obtained were similar to those reported in a separate study of women treated in Birmingham. The results of that study, however, may have been due to the age distribution in the population of women by parity, rather than any direct influence of parity on the speed of growth of breast cancer.
Clinical Course of Myocardial Infarction Among Diabetic Patients
Authors: Artur Czyżk, Andrzej S Królewski, Sylvia Szabłowska, Aleksandra Alot, Jan Kopczyński
Journal: Diabetes Care (1980)

The clinical course of myocardial infarction (MI) was compared between 154 known diabetic (Ds) and nondiabetic (NDs) MI patients matched for age, sex, and hospital ward. In both groups similar numbers of cases with cardiac rupture, shock, pulmonary edema, and clinically observed arrhythmias were found. In contrast, Ds patients had significantly more frequent A-V and intraventricular conduction disorders than NDs (P less than 0.02). Ds also died twice more often from MI (36%) than matched controls (18%). The excess case fatality rates from MI among Ds were limited to the period between the second and seventh day of hospitalization. The excessive fatality of Ds from MI resulted mainly from the high liability of insulin-dependent diabetic patients (IDDs), with the relative risk of over 4 in relation to NDs. Ds with arrhythmias and/or conduction disorders had a particularly poor prognosis for surviving, the relative risk exceeding 3. No ready explanation of this phenomenon is presently available.
Glucose-Insulin-Potassium Therapy in Patients With STEMI
Authors: Harry P. Selker
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The National Children's Study: A Critical National Investment
Authors: Leonardo Trasande, Philip J. Landrigan
Journal: Environmental Health Perspectives (2004)

The NCS has benefited from strong and bipartisan leadership in Congress and from the support of a broad-based coalition that includes the American Academy of Pediatrics, the U.S. Conference of Catholic Bishops, the American Chemistry Council, the Learning Disabilities Association, and the March of Dimes.But still it is in dire fiscal peril.The NCS represents an extraordinary
If the Fates Allow
Authors: Tim Wolter
Journal: Annals of Internal Medicine (1999)

On Being a Doctor20 July 1999If the Fates AllowTim Wolter, MDTim Wolter, MDFamily Health Associates; Chippewa Falls, WI 54729 (Wolter)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-2-199907200-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Through the years we all will be together,If the Fates allow,Hang a shining star upon the highest bough.And have yourself a merry little Christmas now …”I hadn't thought much about the Fates recently, even though I had sung this song while out caroling a few days earlier. It was a busy day at the office, shorthanded as we were because of vacations. No time to be musing on the incongruity of pagan goddesses making a cameo appearance in a song, albeit a rather secular one, celebrating the birth of Christ.To the ancients, the Fates were ... Author, Article, and Disclosure InformationAuthors: Tim Wolter, MDAffiliations: Family Health Associates; Chippewa Falls, WI 54729 (Wolter)Corresponding Author: Tim Wolter, MD, Family Health Associates, 2449 County Highway 1, Chippewa Falls, WI 54729; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 July 1999Volume 131, Issue 2Page: 148-149KeywordsCellsKidneysMemoryPathologistsPersonalityResearch laboratoriesRunningTechniciansUreterVentricular tachycardia ePublished: 15 August 2000 Issue Published: 20 July 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Contraceptives and Acute Salpingitis
Authors: Lars Svensson
Journal: JAMA (1984)

In 546 women with a first episode of salpingitis, the degree of inflammation of the fallopian tubes, as seen during laparoscopy, was graded into mild, moderate, and severe. The patients were subgrouped according to contraceptive use into (1) reference group (women not using intrauterine [contraceptive] devices [IUDs] or oral contraceptives [OCs]), (2) IUD group, and (3) OC group. Mild, moderate, and severe salpingitis occurred in 51.3%, 34.6%, and 24.1% of the women in the reference group. The corresponding percentages for the women in the IUD group were 54.6%, 29.7%, and 15.7% and for the patients in the OC group, 73.5%, 17.1%, and 9.4%, respectively. Women using OCs had significantly milder degrees of inflammation of the fallopian tubes than women with other contraceptive methods. Age could not explain the differences. (<i>JAMA</i>1984;251:2553-2555)
Better research for better healthcare
Authors: S. Petit-Zeman
Journal: Journal of the Royal Society of Medicine (2006)

Better research for better healthcareThe ill-fated TGN1412 phase I study and Prince Charles versus the medical establishment over complementary therapies recently pushed evidence-based medicine and clinical trials into prominence.For a society with poor vocabulary about probability, risk and uncertainty, and which increasingly blurs boundaries between well and ill, moving the debates forward, and in unity, will be tough.Prince Charles called for orthodox medicine to learn from alternative, telling the World Health Assembly in Geneva 'The proper mix of proven complementary, traditional and modern remedies, which emphasizes the active participation of the patient, can help to create a powerful healing force in the world'.Which begs the question 'What's the proof?'.In parallel, 13 eminent doctors wrote to acute and primary care trusts urging them to review practices with regard to 'ways in which unproven or disproved treatments are being encouraged for general use in the NHS'. 1 About half of all general practitioners refer patients to alternative practitioners, and should stop if it is pointless.As clinical scientist Leslie Rose said, the letter was to 'instill equal vigour in gathering evidence for every treatment prescribed to NHS patients', adding that a business plan for refurbishing the Royal London Homoeopathic Hospitalwhich cost £20m to set up-put no emphasis on evidence.£20m can buy a lot of what works, and such support begs questions about government consistency in calling for hard evidence for healthcare.The hospital's Dr Peter Fisher described the letter as an attempt to introduce 'medical apartheid' into the National Health Service, and Terry Cullen, of the British Complementary Medicine Association, said: 'There is so much anecdotal evidence that thousands of people gain benefit from using complementary medicines.We shouldn't dismiss that'.He is right: which is where a major problem arisesconfusing treating illness with 'gaining benefit', and indeed anecdote with evidence.The World Health Organization defines health as 'a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity'. 2. But the NHS has enough to do without being charged-in both senses-with creating this nirvana.Hoards of sensible, bright people swear by various blends of snake oil for multiple malaises, from back pain to itchy skin to mild melancholy.And maybe it is more powerful.But we need hard evidence that we can cure cancer, bypass a heart or silence schizophrenic voices with homeopathy, reiki, reflexology or aromatherapy.That is not to say they
Hemolytic Anemia Associated With Cephalothin
Authors: Harvey R. Gralnick
Journal: JAMA (1971)

Two patients developed Coombs' positive hemolytic anemia while receiving cephalothin sodium therapy. An anticephalothin antibody was detected in the IgG fraction of sera and in the red blood cell (RBC) eluates in both patients. This complication of cephalothin therapy is rare, and must be differentiated from the positive Coombs' reaction seen in the majority of patients receiving cephalothin. In any patient receiving cephalothin, unexplained hemolysis must include a search for anticephalothin and antipenicillin antibodies on the RBC before the drug can be implicated in any hemolytic episode.
Diseases of the Skin in Children and Adolescents: A Color Atlas
Authors: Samuel M. Bluefarb
Journal: JAMA (1970)

A small German atlas on<i>Diseases of the Skin in Children and Adolescents</i>was published in 1969 and the Drs Curth have translated and adapted the text for an American edition. Korting justifies a children's atlas by stating that the child shows basic morphologic and functional differences which apply to the skin. These include longer life of epidermal cells, higher elasticity of the tissue, increased tendency to bullous formations, and activity of apocrine glands at puberty. There are 398 illustrations of which 390 are in color. The colored illustrations are excellent and the text, which is concise and pertinent, has been ably translated by the Curths. A few criticisms I found were: Fig 18 is probably granuloma annulare rather than erythema elevatum diutinum; many adult diseases are described in the text; and the labelling of diaper rash as chancriform pyoderma seems unwarranted. These are minor criticisms for such a well-designed
Abstract 2592: <i>Helicobacter pylori</i> induces phosphorylation of STAT3 Tyr705 and Ser727 in human gastric epithelial cells.
Authors: Juan-Yu Piao, Hee-Geum Lee, Hyeon-Geum Ji, Hyeong-Joon Han, Hoang Kieu Chi Ngo, Do-Hee Kim, Su-Jung Kim, Sung-Young Lee, Young-Joon Surh
Journal: Cancer Research (2013)

Abstract Helicobacter pylroi (H. pylori) infection has been considered to be one of the high risk factors of gastritis and gastric cancer, but its pathogenic implication is still poorly understood. Recent studies indicate that constitutive activation of the signal transducer and activator of transcription 3 (STAT3) plays an important role in inflammation-associated carcinogenesis. In our previous study, we found that the phosphorylation of STAT3 at Tyr705 was increased in H. pylori plus high salt diet-induced gastritis in a mouse model. The similar results were observed in human gastric AGS cells co-cultured with H. pylori. Interestingly, H. pylori induced phosphorylation of STAT3 at not only Tyr705 but also Ser727. However, the phosphorylation of two residues exhibited different profiles in human gastric epithelial cells upon H. pylori treatment. The phosphor-Tyr705 increased at early time of H. pylori infection and then decreased immediately, but phosphor-Ser727 increased thereafter which was first discovered in our present study. Phosphorylation of STAT3 is an essential event for inducing the expression of anti-apoptotic/survival proteins, such as Bcl-XL, BcL-2, survivin and c-Myc which contribute to gastric carcinogenesis. Levels of all these proteins were elevated in H. pylori-infected AGS cells. In conclusion, H. pylori induces phosphorylation of STAT3 at both Tyr705 and Ser727 residues. The role of phospohorylation of STAT3 at the Serine 727 residue in H. pylori-induced gastritis and gastric cancer is under investigation. Citation Format: Juan-Yu Piao, Hee-Geum Lee, Hyeon-Geum Ji, Hyeong-Joon Han, Hoang Kieu Chi Ngo, Do-Hee Kim, Su-Jung Kim, Sung-Young Lee, Young-Joon Surh. Helicobacter pylori induces phosphorylation of STAT3 Tyr705 and Ser727 in human gastric epithelial cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2592. doi:10.1158/1538-7445.AM2013-2592
Abstract 4234: Ursolic acid induces apoptosis in pancreatic cancer cells associated with inhibition of STAT3 and down-regulation of Bcl-XL
Authors: Ana S. Leal, Jorge Salvador, Yongkui Jing
Journal: Cancer Research (2011)

Abstract Pancreatic cancer is the fourth leading cause of cancer death and without effective medical therapy. New agents acting on novel targets need to be developed. Natural products provide a promising source for developing effective anticancer agents. Oleanolic acid (OA) and ursolic acid (UA) are two natural triterpenoids with reported antitumor activities in several types of cancer. The antitumor effects of OA, oleanolic acid methyl ester (OAME) and UA were determined in pancreatic cancer Aspc-1 cells. Cell growth inhibition of the three compounds was determined using the MTT assay. The IG50s of OA, OAME and UA after treatment with UA for 4 days are &amp;gt;30, 8.9, 12.5 μM, respectively. OA is a weak cell growth inhibitor and methyl esterification improves its antitumor activity. UA is more effective than OA to inhibit cell growth in Aspc-1 cells and was used to study the mechanism of action. Aspc-1 cells treated with UA at a concentration higher than 25 uM induced apoptosis as determined by PARP cleavage detection. Western blot analysis revealed that the levels of procaspase-3, -9 and Bcl-XL were markedly decreased while the levels of Mcl-1, XIAP and survivin were weakly or not decreased. Correlated with the decrease in the level of Bcl-XL, the level of phosphorylated STAT3 was significantly inhibited. STAT3 is activated in pancreatic cancer cells and contributes to pancreatic tumorigenesis. Activated STAT3 increases the levels of antiapoptotic protein such as Bcl-XL, Mcl-1 and survivin, are being considered as a target for developing agents for pancreatic cancer treatment. Our data suggest that UA is a lead candidate for targeting STAT3 and structural modification of UA may result in a new group of compounds with improved antitumor activity in pancreatic cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4234. doi:10.1158/1538-7445.AM2011-4234
Urinary leukotriene E<sub>4</sub> and 11‐dehydrothromboxane B<sub>2</sub> in patients with aspirin‐sensitive asthma
Authors: R. Oosaki, Y. Mizushima, H. Mita, T. Shida, K. Akiyama, M. Kobayashi
Journal: Allergy (1997)

The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane A 2 in the pathogenesis of aspirin‐sensitive asthma (ASA). Leukotriene E 4 (LTE 4 ) and 11‐dehydrothromboxane B 2 (11DTXB 2 ) values in spot urine were measured in 22 asthmatics with a history of aspirin sensitivity and in 17 without such a history of aspirin‐sensitive asthma [NASA]) in the outpatient clinic. The urinary LTE 4 value was significantly higher in ASA patients than in NASA (340±47 vs 65±15 pg/mg·cr, P &lt;0.001), but there was no significant difference in urinary 11DTXB2 between the two groups (891±77 vs 657±90 pg/mg·cr). A high value of LTE4 was not associated with type of asthma, severity of disease, oral prednisolone treatment, sex, or age. A higher value of 11DTXB 2 was observed in the atopic type than the nonatopic type in ASA (1086±111 vs 697±147 pg/mg·cr, P&lt;0.05). No correlation was observed between urinary LTE 4 and 11DTXB 2 in either ASA or NASA. In conclusion, LTs may play an important role in the pathogenesis of ASA, and TXA 2 in the pathogenesis of the atopic type in ASA.
Taking folic acid at start of pregnancy seems to lower risk of cleft lip and palate
Authors: M. Houston
Journal: BMJ (2012)

The risk of having a cleft lip or palate seems to be more than four times higher if mothers do not take folic acid in the first three months of pregnancy, a study shows.1

Lack of folic acid early in pregnancy is known to cause neural tube defects such as spina bifida, but this is the first study ever to show a strong association between maternal folic acid intake and the risk of a baby developing cleft lip and cleft palate.

Using data generated from over 11 000 babies representing the 9 month old infant cohort of the Growing Up in Ireland Study, Ms Dervla …