tbuckley/cabot-search huggingface dataset:
Potential Effect of Self-Care Algorithms on the Number of Physician Visits
Authors: Alfred O. Berg, James P. LoGerfo
Journal: New England Journal of Medicine (1979)

Abstract To assess the potential effect of self-care algorithms on the number of physician visits, actual visits from the Seattle Virus Watch were compared retrospectively with those recommended by clinical algorithms for common illnesses from the book, Take Care of Yourself, by Vickery and Fries. From a total of 3929 illnesses, records indicating the presence of the index symptom for eight algorithms were identified, determining whether the criteria for seeing a physician were met and whether a physician visit was recorded. The number of visits observed was compared to the number of visits recommended by the algorithms. Strict adherence would have increased the number of visits over that observed for five, remained the same for two, and decreased for one of the algorithms. These results indicate that adherence to some commonly promulgated self-care algorithms may increase rather than decrease the number of physician visits. (N Engl J Med 300:535–537, 1979)
Erythematous Papules and Vesicles on the Palms, Soles, and Oropharynx
Authors: Ramya Kollipara, Jacqueline A. Guidry, Stephen K. Tyring
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Selective Augmentation of Prostacyclin Production by Combined Prostacyclin Synthase and Cyclooxygenase-1 Gene Transfer
Authors: Song-Kun Shyue, May-Jywan Tsai, Jun-Yang Liou, James T. Willerson, Kenneth K. Wu
Journal: Circulation (2001)

Background —We tested the hypothesis that combined cyclooxygenase-1 (COX-1) and prostacyclin synthase (PGIS) gene transfer selectively augments prostacyclin production without a concurrent overproduction of other prostanoids. Methods and Results —ECV304 cells were transfected with bicistronic pCOX-1/PGIS versus pCOX-1 or pPGIS, and prostanoids were analyzed. Contrary to the high prostaglandin E 2 synthesis in pCOX-1 transfected cells, selective prostacyclin formation was noted with bicistronic plasmid transfection. Next, we determined the optimal ratio of Ad-COX-1 to Ad-PGIS by transfecting human umbilical vein endothelial cells with various titers of these 2 adenoviral constructs and determined the level of protein expression and prostanoid synthesis. Our results show that optimal ratios of adenoviral titers to achieve a large prostacyclin augmentation without overproduction of prostaglandin E 2 or F 2α were 50 to 100 plaque forming units (pfu) of Ad-COX-1 to 50 pfu of Ad-PGIS per cell. A higher Ad-PGIS to Ad-COX-1 ratio caused a paradoxical decline in prostacyclin synthesis. Conclusions —Prostacyclin synthesis can be selectively augmented by cotransfecting endothelial cells with an optimal ratio of COX-1 to PGIS. Combined COX-1 and PGIS gene transfer has the potential for therapeutic augmentation of prostacyclin.
International findings point to third hepatitis virus
Authors: Charles Marwick
Journal: JAMA (1984)

One of the long-sought viruses of non-A, non-B hepatitis may have been discovered.  If the preliminary findings identifying the agent hold up—and there are reports suggesting that they will—the way would be open toward preventing a major remaining form of hepatitis. This prevention could be accomplished both by screening out the agent from blood used for transfusions and possibly also by developing a vaccine along the lines of the present agent against hepatitis B.  The end result would be to reduce still further the incidence of this major and often fatal liver disease. About 90% of transfusion-associated hepatitis is caused by the non-A, non-B agent, according to experts.  Ever since the two viruses of hepatitis—A and B—were identified, epidemiologic evidence has pointed to at least a third hepatitis virus. But it has eluded identification.  Now a group of investigators working in the United States and Sweden believes it has found
Poets on Prozac: Mental Illness, Treatment, and the Creative Process
Authors: Tony Miksanek
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Neonatal jaundice in association with operative delivery.
Authors: O B Eden
Journal: BMJ (1976)

weakness in any other muscle groups.Two separate Tensilon tests (10 mg edrophonium chloride) wvith saline control were performed in a double-blind manner.After the first injection of edrophonium chloride the ptosis improved greatly, and two days later with the second test the im- provement was less marked.After the Tensilon tests all therapy was stopped and the patient referred to the late Professor Andrew Wilson, who suggested that this myasthenic syndrome might be related to the practolol.Electromyography revealed no abnormality, nor did it six months later, when the patient had been off all therapy.Investigations including ESR, haemoglobin, blood urea and electrolytes, thyroid function tests, and x-rays of the mediastinum revealed no abnormality.The myasthenic symptoms have not recurred following the second dose of edrophonium chloride, but because the patient's blood pressure rose after stopping the practolol he was restarted on spironolactone 100 mg daily and bendrofluazide 5 mg daily.
1113-153 Relative importance of errors in s-D echocardiographic calculation of left ventricular volumes: Insights from live 3-D echocardiography and cardiac magnetic resonance imaging
Authors: Rupa R Krishnaswamy, Aasha S Gopal, Rena S Toole, Florentina Petillo, William Schapiro, Nathaniel Reichek
Journal: Journal of the American College of Cardiology (2004)
Practical Management of Anticoagulation in Patients With Atrial Fibrillation
Authors: Richard J. Kovacs, Greg C. Flaker, Sherry J. Saxonhouse, John U. Doherty, Kim K. Birtcher, Adam Cuker, Bruce L. Davidson, Robert P. Giugliano, Christopher B. Granger, Amir K. Jaffer, Bella H. Mehta, Edith Nutescu, Kim A. Williams
Journal: Journal of the American College of Cardiology (2015)
SOME EFFECTS OF THE TAKING OFF OF THE CEREBRO-SPINAL PRESSURE. ANEMIA OF THE BRAIN AND • WOUNDS OF THE SINUSES.Read before the Missouri State Medical Association at Sedalia, Mo., May, 1893.
Authors: GEORGE HALLEY
Journal: JAMA (1893)

immediately before and after it, and the services of two attendants and one of the house staff are required during most of this time.To give 2,052 baths would therefore occupy three persons for 1,026 hours or over forty-two days.It is useless to undertake the Brand system unless.one is prepared to carry it out with careful detail and much labor.
PRESYMPTOMATIC CENTRAL NERVOUS SYSTEM THERAPY IN PREVIOUSLY UNTREATED CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA: COMPARISON OF 1800 RAD AND 2400 RAD
Authors: MarkE. Nesbit, LeslieL. Robison, PhillipS. Littman, HarlandN. Sather, Jorge Ortega, GiulioJ. D'Angio, G. Denman Hammond
Journal: The Lancet (1981)
Using Pulmonary Imaging to Move Chronic Obstructive Pulmonary Disease beyond FEV<sub>1</sub>
Authors: Harvey O. Coxson, Jonathon Leipsic, Grace Parraga, Don D. Sin
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

Section:ChooseTop of pageAbstract <<Overview: FEV1 Is Not Eno...Computed Tomography Measu...CT Caveats and Potential ...MRI Measurements of COPDFuture DirectionsReferencesCITING ARTICLES
The effect of streptokinase on intramyocardial hemorrhage, infarct size, and the no-reflow phenomenon during coronary reperfusion.
Authors: R A Kloner, K J Alker
Journal: Circulation (1984)

The purpose of this study was to determine whether streptokinase exacerbates intramyocardial hemorrhage during coronary reperfusion, has any intrinsic effect on myocardial infarct size other than its ability to lyse proximal thrombi in coronary arteries, and can abolish the no-reflow phenomenon. Anesthetized open-chest dogs underwent coronary occlusion for 3 hr followed by 3 hr of reperfusion. Area of infarct was assessed by tetrazolium staining, anatomic zone of no-reflow by injection of the fluorescent dye thioflavin S at the end of the reperfusion period, regional blood flow during occlusion and reperfusion by the radioactive microsphere technique, and extent of gross hemorrhage by assessment of photographic enlargements of the heart slices. Area of infarction of the left ventricle was similar in control (13.4 +/- 3.6%) and streptokinase-treated dogs (13.0 +/- 2.9%; p = NS). Seven of eight dogs in the untreated group had anatomic perfusion defects as assessed by thioflavin S at the end of the reperfusion phase; seven of eight dogs in the streptokinase group had anatomic perfusion defects. There was no difference in the extent of gross hemorrhage between the two groups (6.5 +/- 2.1% of left ventricle in controls and 5.7 +/- 2.3% in streptokinase-treated dogs). Severe depression of regional blood flow during reperfusion was present within the infarcted tissue and was associated with an anatomic perfusion defect as defined by thioflavin S; there was moderate depression of flow within the noninfarcted, salvaged subepicardium. In a separate series of experiments, infarcts were assessed for hemoglobin content. Intramyocardial hemoglobin levels were not higher after fibrinolytic therapy plus reperfusion compared with reperfusion alone.(ABSTRACT TRUNCATED AT 250 WORDS)
Along US Southern Border, Pollution, Poverty, Ignorance, and Greed Threaten Nation's Health
Authors: Andrew A. Skolnick
Journal: JAMA (1995)

TWO ROOSTERS scurry from the path of Cynthia Lopez' car as she pulls into the dusty front yard of a home on the west side of El Paso, Tex, where Maria Ramos and her family live. Lopez, an epidemiologist, has stopped by to explain the results of laboratory tests on a sample of the Ramos' well water she collected during an earlier visit.  Ramos and her family live in a substandard dwelling in the colonia called Campestre. As in most of the hundreds of other colonias that have sprung up along both sides of the US-Mexico border, Campestre's houses have no connection to water or sewer lines. Most have shallow pumps that draw water from the Rio Grande flood plain, which is badly contaminated with human, animal, and industrial wastes. Many also have illegal or nonconforming outhouses, cesspools, or latrines that add to the contamination.  Speaking in Spanish, Lopez tells
229 SUCCESSFUL CONVERSION FROM MYCOPHENOLATE MOFETIL TO ENTERIC-COATED MYCOPHENOLATE SODIUM (MYFORTIC®) IN LIVER TRANSPLANT PATIENTS WITH GASTROINTESTINAL SIDE EFFECTS
Authors: G. Robaeys, D. Cassiman, C. Verslype, D. Monbaliu, R. Aerts, J. Pirenne, F. Nevens
Journal: Journal of Hepatology (2008)
Hugh Cooper Barr
Authors: R. Barr
Journal: BMJ (2011)

Hugh Cooper Barr was a farmer’s son from Lanarkshire born in 1923. He attended school in Lanark and then George Watson’s College in Edinburgh. On finishing school and after an initial six months at Edinburgh University, he joined the Royal Air Force.

His flying training took place over the great plains of Canada, leaving him a lifelong affection for the country and flying. Coming top in his navigation exam allowed him to assume a role as a night fighter pilot. He joined 153 Squadron to fly Beaufighters. At that time they were based in Algiers flying convoy protection over the Mediterranean. He would regale us with tales of flying over to Gibraltar for lunch, crayfish, but few tales of the battle. One such was flying with two other Beaufighters over Malta to engage Italian bombers. At the limit of their range and fuel low, they dived, firing their cannon to see the bombers break and turn for home. No lives were lost that day, only lives saved.

He returned to the England to assume a role …
Harlequin baby: inheritance and prognosis
Authors: F. Lawlor
Journal: British Journal of Dermatology (1987)

Journal Article Harlequin baby: inheritance and prognosis Get access F. Lawlor F. Lawlor Department of Dermatology, Coventry and Warwickshire Hospital, Coventry CV1 4FH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 4, 1 October 1987, Page 528, https://doi.org/10.1111/j.1365-2133.1987.tb04935.x Published: 01 October 1987
Improved control of long-term anticoagulant therapy.
Authors: R. D. Eastham
Journal: BMJ (1969)

seems to overlook certain points.If his contention were correct there would, I suggest, be no need for the Medical Act, 1956, to require the setting-up of a Medical Disciplinary Committee, which is indepen- dent of the Council in its decisions.This provision for a separation of functions would appear to meet Professor Black's objection and to put the G.M.C. in a similar position to the Pharmaceutical Society, whose struc- ture and powers in relation to discipline are not significantly different.'Any difficulty in the G.M.C. taking action seems to lie in the rules of the Disciplinary Committee, which provide for complaints coming from outside and not originating in the G.M.C.' The corresponding regulations of the society's disciplinary committee- that is, the Statutory Committee-have no such limitation.'Although a complaint may be made by anyone, virtually all complaints to the Statutory Committee are made by the council of the society, who regard it as their responsibility not only to give guidance to pharmacists on matters of professional con- duct but also to take the initiative in formu- lating and submitting complaints to the com- mittee from information within their know- ledge, however obtained.
A GRAPHIC DEMONSTRATION OF INSULIN DOSAGE
Authors: Harold M. Bowcock
Journal: JAMA (1930)

Many diabetic patients have difficulty in understanding the relationship between volume and unit dosage of insulin. This difficulty is made greater by the variety of hypodermic syringes in use. Each type of syringe possesses certain advantages and disadvantages. The "insulin syringe" with its multiple graduations for different strengths of insulin may be particularly confusing to unintelligent patients. Syringes of 1 cc. capacity are more accurate for the measurement of small quantities, and should be used for U-40 and U-80 insulin. On the other hand, small syringes are usually less substantial and less easily handled by the inexperienced than a larger syringe. A type of syringe which can be replaced readily should be chosen. While I was directing the treatment of sixty-five colored diabetic patients in the outpatient department of Grady Hospital at Emory University,<sup>1</sup>the foregoing difficulties became apparent and demanded a solution. Consequently, blanks such as that shown
Use of the Child Health Questionnaire in a Sample of Moderate and Low-Income Inner-City Children with Asthma
Authors: LINDA ASMUSSEN, LYNN M. OLSON, EVALYN N. GRANT, JEANNE M. LANDGRAF, JOANNE FAGAN, KEVIN B. WEISS
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The Child Health Questionnaire (CHQ-PF50) is one of several recent efforts to gauge pediatric, health-related quality of life from the patient's (or parent's) perspective. Although tested extensively with healthy children, more information is needed about CHQ performance among children with chronic conditions such as asthma. The current study extends previous work by examining the CHQ's psychometric performance in a sample of children with asthma, overrepresenting those at high risk for poor outcomes. Seventy-four adult caregivers of children with asthma completed the CHQ. Internal consistency reliability was consistently high for all but one scale. Intraclass correlation coefficients ranged from a low of 0.37 to a high of 0.84. Tests of validity found CHQ scales better at distinguishing levels of disease severity as defined by symptom activity than medication use or pulmonary function tests. Performance of the CHQ-PF50 in a sample of low-income to moderate income inner-city parents of children with asthma presented mixed results. The instrument addresses a broad range of concepts but some scales may be more salient than others in assessing health status of children at highest risk for asthma morbidity. Future efforts must compare condition-specific and generic instruments to evaluate their relative strengths and weakness, as well as potential links between them.
Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection
Authors: Eric Lawitz, Alessandra Mangia, David Wyles, Maribel Rodriguez-Torres, Tarek Hassanein, Stuart C. Gordon, Michael Schultz, Mitchell N. Davis, Zeid Kayali, K. Rajender Reddy, Ira M. Jacobson, Kris V. Kowdley, Lisa Nyberg, G. Mani Subramanian, Robert H. Hyland, Sarah Arterburn, Deyuan Jiang, John McNally, Diana Brainard, William T. Symonds, John G. McHutchison, Aasim M. Sheikh, Zobair Younossi, Edward J. Gane
Journal: New England Journal of Medicine (2013)

In phase 2 trials, the nucleotide polymerase inhibitor sofosbuvir was effective in previously untreated patients with chronic hepatitis C virus (HCV) genotype 1, 2, or 3 infection.We conducted two phase 3 studies in previously untreated patients with HCV infection. In a single-group, open-label study, we administered a 12-week regimen of sofosbuvir plus peginterferon alfa-2a and ribavirin in 327 patients with HCV genotype 1, 4, 5, or 6 (of whom 98% had genotype 1 or 4). In a noninferiority trial, 499 patients with HCV genotype 2 or 3 infection were randomly assigned to receive sofosbuvir plus ribavirin for 12 weeks or peginterferon alfa-2a plus ribavirin for 24 weeks. In the two studies, the primary end point was a sustained virologic response at 12 weeks after the end of therapy.In the single-group study, a sustained virologic response was reported in 90% of patients (95% confidence interval, 87 to 93). In the noninferiority trial, a sustained response was reported in 67% of patients in both the sofosbuvir-ribavirin group and the peginterferon-ribavirin group. Response rates in the sofosbuvir-ribavirin group were lower among patients with genotype 3 infection than among those with genotype 2 infection (56% vs. 97%). Adverse events (including fatigue, headache, nausea, and neutropenia) were less common with sofosbuvir than with peginterferon.In a single-group study of sofosbuvir combined with peginterferon-ribavirin, patients with predominantly genotype 1 or 4 HCV infection had a rate of sustained virologic response of 90% at 12 weeks. In a noninferiority trial, patients with genotype 2 or 3 infection who received either sofosbuvir or peginterferon with ribavirin had nearly identical rates of response (67%). Adverse events were less frequent with sofosbuvir than with peginterferon. (Funded by Gilead Sciences; FISSION and NEUTRINO ClinicalTrials.gov numbers, NCT01497366 and NCT01641640, respectively.).
Osteoprotegerin serum levels in multiple myeloma and MGUS patients compared with age- and sex-matched healthy controls
Authors: A Corso, A Dovio, C Rusconi, M L Sartori, C Klersy, M Varettoni, S Mangiacavalli, P Zappasodi, M Ventura, A Angeli, M Lazzarino
Journal: Leukemia (2004)
Blood Donor Groups and Crossing Over-Reply
Authors: Jane M. Starkey
Journal: JAMA (1990)

In Reply.—  With reference to Dr Fawcett's point that blood centers from areas regarded as foci of acquired immunodeficiency syndrome did not participate in the data collection, we did not intend that their information should be used as a national average. The purpose was, rather, to see if there were differences in the prevalence of infectious markers between groups of donors (volunteer, autologous, and directed) who were donating for dissimilar reasons.  We agree that the decision to crossover untransfused units should be made on the basis of patient safety. In this regard, it is not possible to ignore the fact that autologous blood available for crossover has a greater likelihood of being positive for some markers of infectious disease.
754 EFFICACIES OF ONE YEAR NUCLEOS(T)IDE ANALOGUE THERAPY IN INTRAHEPATIC HBVDNA AND COVALENTLY CLOSED CIRCULAR DNA REDUCTION
Authors: D. Wong, C.L. Lai, W.K. Seto, J. Fung, F.Y. Huang, I. Hung, M.F. Yuen
Journal: Journal of Hepatology (2011)
Mortality among Pesticide Applicators Exposed to Chlorpyrifos in the Agricultural Health Study
Authors: Won Jin Lee, Michael C.R. Alavanja, Jane A. Hoppin, Jennifer A. Rusiecki, Freya Kamel, Aaron Blair, Dale P. Sandler
Journal: Environmental Health Perspectives (2007)

Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited.To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we examined deaths among pesticide applicators in the Agricultural Health Study, a prospective study of licensed pesticide applicators in Iowa and North Carolina.A total of 55,071 pesticide applicators were included in this analysis. Detailed pesticide exposure data and other information were obtained from self-administered questionnaires completed at the time of enrollment (1993-1997). Lifetime chlorpyrifos use was divided into tertiles. Poisson regression analysis was used to evaluate the exposure-response relationships between chlorpyrifos use and causes of death after adjustment for potential confounders.A total of 1,851 deaths (588 among chlorpyrifos users) were observed during the study period, 1993-2001. The relative risk (RR) of death from all causes combined among applicators exposed to chlorpyrifos was slightly lower than that for nonexposed applicators (RR = 0.90; 95% confidence interval, 0.81-1.01). For most causes of death analyzed, there was no evidence of an exposure-response relationship. However, the relative risks for mortality from suicide and non-motor-vehicle accidents were increased 2-fold in the highest category of chlorpyrifos exposure days.Our findings of a possible association between chlorpyrifos use and external causes of death were based on small numbers. However, the findings may reflect a link between chlorpyrifos and depression or other neurobehavioral symptoms that deserves further evaluation.