tbuckley/cabot-search huggingface dataset:
Mouth Ulcers Associated With Prolonged Chewing of Gum Containing Aspirin
Authors: Henry N. Claman
Journal: JAMA (1967)

Progressive ulcerations of the tongue and buccal mucosa developed in an adult man. The history indicated that the patient probably had herpetic stomatitis which healed spontaneously. However, to assuage the pain of the original disease, he chewed gum containing aspirin for at least two months, and ulcers developed secondary to local effects of the aspirin. No other cause for the ulcers was found, and they healed promptly after the gum was discontinued.
749 EARLY ON-TREATMENT RESPONSES DURING PEGYLATED IFN PLUS RIBAVIRIN ARE INCREASED FOLLOWING 13 DAYS OF COMBINATION NUCLEOSIDE POLYMERASE (RG7128) AND PROTEASE (RG7227) INHIBITOR THERAPY (INFORM-1)
Authors: E. Gane, S. Roberts, C. Stedman, P. Angus, B. Ritchie, R. Elston, D. Ipe, P. Morcos, L. Baher, I. Najera, T. Chu, M. Mannino, M. Berry, W. Bradford, M. Laughlin, N. Shulman, P. Smith
Journal: Journal of Hepatology (2010)
Identification of IgE sequential epitopes of lentil (Len c 1) by means of peptide microarray immunoassay
Authors: Andrea Vereda, Doerthe A. Andreae, Jing Lin, Wayne G. Shreffler, Maria Dolores Ibañez, Javier Cuesta-Herranz, Ludmilla Bardina, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2010)
LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β
Authors: Stéphane Peineau, Changiz Taghibiglou, Clarrisa Bradley, Tak Pan Wong, Lidong Liu, Jie Lu, Edmond Lo, Dongchuan Wu, Emilia Saule, Tristan Bouschet, Paul Matthews, John T.R. Isaac, Zuner A. Bortolotto, Yu Tian Wang, Graham L. Collingridge
Journal: Neuron (2007)
Something is rotten in the state of angiogenesis — H2S as gaseous stimulator of angiogenesis
Authors: I HOEFER
Journal: Cardiovascular Research (2007)

The research on a new class of signaling molecules, later named gaseous transmitters or gasotransmitters, started in 1986 with the discovery that the so-called endotheliumderived relaxing factor (EDRF) is identical to nitric oxide [1].This finding was later awarded with the Nobel Prize and NO was named "molecule of the year" in 1992.Since then, countless studies have focused on the role of NO in various processes, among which its cardiovascular effects still remain most prominent.A few years later, NO was accompanied by a second biologically active gaseous molecule, carbon monoxide (CO), recently followed by the "rotten egg gas" hydrogen sulfide (H 2 S), and others are likely to be discovered, expanding the family of known gasotransmitters in the future.What turns these molecules into gasotransmitters is their ability to induce either endocrine, paracrine, or autocrine effects.They are freely permeable to cell membranes and bind to receptors other than known membrane receptors, which remain to be identified.Another common feature of these 3 known gasotransmitters is their toxic effects in higher concentrations.Despite their toxicity, they are endogenously produced in significant amounts; the toxic effect level of e.g.H 2 S is only twice as high as the concentrations in brain tissue, demanding a delicate regulating mechanism to maintain physiological levels [2].H 2 S is endogenously generated from L-cysteine by two distinct enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE), which are responsible for the majority of H 2 S in mammalian tissue.The expression of
Introduction to Gastrointestinal Physiology
Authors: Stanley H. Lorber
Journal: JAMA (1968)

This text is based on a series of ten lectures in gastrointestinal physiology given by the author, who is an outstanding authority on the chemistry of gastric secretory products, Vitamin B<sub>12</sub>metabolism, and gastric physiopathology. Approximately one fourth of the book is devoted to gastric secretion, the major interest of the author. This section is presented in concise fashion, and the motor, secretory, and biochemical functions of the stomach are all expertly considered. The book covers esophageal function, regulation of intake, pancreatic secretion, biliary secretion, physiology of the small intestine and colon, defecation, liver function, etc, but some things are gone over in cursory fashion, others in much greater detail. No attempt is made to be overly comprehensive about the intricate chemistry of the liver, which the author defers to specialized texts on the subject. On the other hand, there is excellent balance to the general considerations of functions
DLQI and CDLQI scores should not be combined
Authors: A.Y. Finlay, M K.A. Basra
Journal: British Journal of Dermatology (2012)

Journal Article DLQI and CDLQI scores should not be combined Get access A.Y. Finlay, A.Y. Finlay Department of Dermatology and Wound Healing, Cardiff University School of Medicine, Cardiff CF14 4XN, U.K. E‐mail: finlayay@cardiff.ac.uk Search for other works by this author on: Oxford Academic Google Scholar M K.A. Basra M K.A. Basra Department of Dermatology and Wound Healing, Cardiff University School of Medicine, Cardiff CF14 4XN, U.K. E‐mail: finlayay@cardiff.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 167, Issue 2, 1 August 2012, Pages 453–454, https://doi.org/10.1111/j.1365-2133.2012.10922.x Published: 01 August 2012
ADDITION OF NEPROLYSIN INHIBITOR, LBQ-657 TO ANGIOTENSIN RECEPTOR BLOCKER, VALSARTAN PROVIDES SUPERIOR ANTI-FIBROTIC AND ANTI-HYPERTROPHIC EFFECTS IN VITRO
Authors: Bing H. Wang, Thomas von Lueder, Li Huang, Andrew Kompa, Randy Webb, Pierre Jordaan, Henry Krum
Journal: Journal of the American College of Cardiology (2012)
Type 2 Diabetes and Impaired Glucose Tolerance in Two Young Adults Infected With HIV Early in Life
Authors: David Dimock, Julia B. Purdy, Rohan Hazra, Colleen Hadigan
Journal: Diabetes Care (2011)

Even though studies demonstrate improved insulin resistance following alterations in HIV antiretroviral therapy (ART) (1), there are no published reports documenting reversal of diabetes. We report on one HIV-infected youth who met criteria for diabetes and one HIV-infected young adult with impaired glucose tolerance (IGT), both of whom experienced significant improvements at 1 and 2 years after ART modification.

Case 1 is a 15-year-old Caucasian male with vertically acquired HIV. He had 12 years of cumulative ART exposure. Past medical history included Burkitt's lymphoma in remission for 5 years, transient IGT, and adrenal insufficiency related to megestrol acetate at age 10, hypertriglyceridemia treated with fenofibrate, and lipoatrophy. At age 15 years and 9 months, he was on lamivudine/stavudine/tenofovir/lopinavir/ritonavir (started at age 11 years) with well-controlled HIV. Fasting glucose was 98 mg/dL, and 2-h postchallenge glucose was 96 mg/dL. …
Thiazide-induced hypokalemia. Association with acute myocardial infarction and ventricular fibrillation
Authors: M. Duke
Journal: JAMA (1978)

Ten of 59 patients (17%) were receiving a thiazide preparation at the time of an acute myocardial infarction and ventricular fibrillation. Hypokalemia was present in seven of eight patients (87%) receiving thiazides, whereas it was observed in only one of 38 patients (2.6%) not receiving these medications. If hypokalemia is present in patients receiving thiazides who have had an acute myocardial infarction, it should be corrected so as to remove this predisposing cause of ventricular fibrillation.
Efficacy of low-pressure, thermally-mediated balloon angioplasty as assessed by intravascular ultrasound
Authors: Daniel B. Fram, Brenda W. Sanzobrino, Joseph F. Mitchel, John P. Fisher, Francis J Kiernan, Linda Gillam, Arnold Fieldman, John E. Abele, Raymond G. McKay
Journal: Journal of the American College of Cardiology (1991)
Semi-Quantitative Immunochromatographic Test for Prostate Specific Antigen in Whole Blood: Tossing the Coin to Predict Prostate Cancer?
Authors: Frank Oberpenning, Stefan Hetzel, Christoph Weining, Burkhard Brandt, Gabriela De Angelis, Achim Heinecke, Michael Lein, Paolo Fornara, Hans-Peter Schmid, Lothar Hertle, Axel Semjonow
Journal: European Urology (2003)
Application of a Theoretic T-Wave Model to Experimentally Induced T-Wave Abnormalities
Authors: MARY JO BURGESS, KENICHI HARUMI, J. A. ABILDSKOV
Journal: Circulation (1966)

A series of experiments was performed to test the validity of a theoretic T-wave model. This model was based on the sequence of depolarization and on multiple action potentials taken in appropriate time phase. The previously introduced concept of the component gradient vector was extended so that this quantity included base-line and local gradient vectors. Component gradient vectors were defined as those vectors produced by a disparity in the configuration of coexisting action potentials. They were directed along the same axis as the depolarization vectors in the area where the component gradient existed. The magnitude of the component gradient vectors was determined by the degree to which the plateau durations and downstrokes of coexisting action potentials differed. Those component gradient vectors that arose from the normal disparity in configuration of ventricular action potentials were defined as base-line gradient vectors, while vectors that arose from a deviation from that state were defined as local gradient vectors. In the experiments reported, the predicted T-wave changes occurred. The maximal T vector tended to move along an imaginary line that was perpendicular to the line closing normal activation fronts in the area in which the local gradient was introduced. In a quantitative test of the model, FRP was measured and used as an indirect measure of the duration of the action potential plateau. The observed changes in T area were proportional to the magnitude of changes in functional refractory period (FRP). The results of these limited experiments indicate that the model should be useful in accounting for the configuration of T waves in states in which localized alterations of action potential configurations occur.
Acute asthma in children of school age
Authors: D. Keeley
Journal: BMJ (2010)

Parent initiated prednisolone is beneficial but the effect is small

Asthma is one of the most common chronic diseases in childhood. Despite improvements in management it is still responsible for around 32 000 hospital admissions and 40 deaths annually in children in the United Kingdom.1 Evidence for the effectiveness of guided self management in improving treatment outcomes is extensive,2 but the contribution of the various components of asthma self management programmes is less clear. Parent initiated treatment of exacerbations with prednisolone is often included in self management plans for children, but evidence for this treatment has been inferred from the confirmed effectiveness of oral corticosteroids in children admitted to hospital with asthma.3

In the linked randomised controlled trial (doi:10.1136/bmj.c843), Vuillermin and colleagues assess this strategy in children of school age and find that prednisolone produces small but definite improvements in symptom scores, reductions in health service usage (number needed to treat 7), and a possible reduction in hospital admissions (NNT 25 with a wide confidence interval).4 So prednisolone helps, but the effect size in this population was small and has to be balanced against the possible harms of repeated courses of oral corticosteroids.

The study is an excellent example of filling a gap in the evidence base for commonly used interventions. The need for the …
Clinical Application of Cryoscopy
Authors: Andrew W. Haraway
Journal: JAMA (1968)

Since 1888 when Beckmann<sup>1</sup>devised the first relatively sensitive apparatus for determining the freezing point of a solution, the medical use of this instrument, the cryoscope or osmometer, has been limited mainly to physiological and clinical research for measuring total solute concentration and osmotic pressure. However, determination of the freezing point of biological fluids also has routine clinical value in assessing certain fluid, electrolyte, and urinary abnormalities. <h3>Osmotic Pressure</h3> When two aqueous solutions of different solute concentrations are separated by a semipermeable membrane, water molecules will move from one solution into the other. This movement is related to the average energy per unit concentration of the water molecules and is referred to as the "escaping tendency," or as the chemical potential. When the chemical potentials of the water molecules of two solutions differ, there will be a net movement of water molecules from the solution with the higher chemical potential
Disorders of the Foot and Ankle: Medical and Surgical Management
Authors: Bernard F. Morrey
Journal: JAMA (1991)

This is a very aggressive and ambitious effort to provide the definitive work by an established author and expert on disorders of the foot and ankle. As a second edition, it is impressive to the extent that it has been revised. The list of contributors is extensive, almost 150 individuals, many with recognized expertise in the areas in which they write. The most notable change from the previous edition is that the present one has expanded from two to three volumes, all prior topics are covered in more detail, and new chapters have been added. The overall organization is reasonable and useful, with the first volume primarily devoted to basic science and pediatric issues, the second dealing with problems of the adult foot, and the final volume discussing traumatic conditions, their treatment complications, and rehabilitation. The editor's goal is to provide the most comprehensive resource for data and information on
Isoniazid and Cancer Risks
Authors: Carolyn T. Miller
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The report on the effectiveness of isoniazid in preventing clinically manifest tuberculosis (229:528, 1974) did not take into account the potential carcinogenicity of the drug. Isoniazid-induced leukemia and tumors in laboratory animals cannot be generalized to man, but they justify careful scrutiny of the potential risk. An increase over expected numbers of deaths due to neoplasms in male tuberculosis patients treated with isoniazid has been observed, although the relative risk (1.4) was not significant statistically.<sup>1</sup>In one section of the randomized trials of the Public Health Service, mental patients under intensive care who had received isoniazid prophylactically experienced a higher rate of death due to neoplasms than did the control group on placebo.<sup>2</sup>The increase in neoplasia was not observed in other test populations. This discrepancy has not been clarified, but it is conceivable that the group under intensive care actually took the prescribed dose
Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation
Authors: Thomas C. Wirth, Hai-Hui Xue, Deepa Rai, Jaime T. Sabel, Tom Bair, John T. Harty, Vladimir P. Badovinac
Journal: Immunity (2010)
Illuminating reasoning and categorization
Authors: Evan Heit, Brett K. Hayes
Journal: Behavioral and Brain Sciences (2005)

The proposal regarding rules and similarity is considered in terms of ability to provide insights regarding previous work on reasoning and categorization. For reasoning, the issue is the relation between this proposal and one-process as well as two-process accounts of deduction and induction. For categorization, the issue is how the proposal would simultaneously explain both similarity-to-rule and rule-to-similarity shifts.
Cardiac tamponade: hemodynamic observations in man.
Authors: P S Reddy, E I Curtiss, J D O'Toole, J A Shaver
Journal: Circulation (1978)

Hemodynamic studies were performed before and after pericardiocentesis in 19 patients with pericardial effusion. Right atrial pressure decreases significantly, from 16 +/- 4 mm Hg (mean +/- SD) to 7 +/- 5 mm Hg in 14 patients with cardiac tamponade. This change was accompanied by significant increases in cardiac output (3.87 +/- 1.77 to 7 +/- 2.2 l/min) and inspiratory systemic arterial pulse pressure (45 +/- 29 to 81 +/- 23 mm Hg). The remaining five patients did not demonstrate cardiac tamponade, as evidenced by lack of significant change in these hemodynamic parameters. In all patients with tamponade, right ventricular end-diastolic pressure (RVEDP) was elevated and equal to pericardial pressure; equilibration was uniformly absent in patients without tamponade. During gradual fluid withdrawal in the tamponade group, significant hemodynamic improvement was largely confined to the period when right ventricular filling pressure remained equilibrated with pericardial pressure. In 10 patients with tamponade and pulsus paradoxus, pulmonary arterial wedge pressure (PAW) was equal to pericardial pressure except during early inspiration and expiration when it was transiently less and greater, respectively; however, inspiratory right atrial pressure never fell below pericardial pressure. In these 10 patients, PAW decreased significantly following pericardiocentesis (P less than 0.001). In the remaining four patients with tamponade but without pulsus paradoxus, all of whom had chronic renal failure, PAW was consistently higher than pericardial pressure or RVEDP and did not decrease after pericardiocentesis. These data tend to confirm the hypothesis that in patients with tamponade, the venous pressure required to maintain any given cardiac volume is determined by pericardial rather than ventricular compliance. When pericardial compliance determines diastolic pressure in both ventricles, relative filling of the ventricles will be competitive and determined by their respective venous pressures (pulmonary vs systemic), which vary with respiration and alternately favor right and left ventricular filling. This results in pulsus paradoxus. However, if pulmonary arterial wedge pressure is markedly elevated before the onset of tamponade, as in patients with chronic renal failure, then pericardial compliance may only determine right ventricular filling pressure. In such cases, pulsus paradoxus may be absent.
Reply to ”A promoter polymorphism in the CASP8 gene is not associated with cancer risk”
Authors: Tong Sun, Yang Gao, Wen Tan, Sufang Ma, Yuankai Shi, Jiarui Yao, Yongli Guo, Ming Yang, Xuemei Zhang, Qingrun Zhang, Changqing Zeng, Dongxin Lin
Journal: Nature Genetics (2008)
Task Force: Evidence Is Lacking That Screening for Glaucoma in the General Public Leads to Improved Outcomes
Authors: Mike Mitka
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lipolytic catecholamine resistance due to decreased beta 2-adrenoceptor expression in fat cells.
Authors: F Lönnqvist, H Wahrenberg, L Hellström, S Reynisdottir, P Arner
Journal: Journal of Clinical Investigation (1992)

The existence of lipolytic beta-adrenoceptor (BAR) resistance was investigated in vivo and in isolated abdominal subcutaneous adipocytes in 65 healthy and drug-free subjects. The concentration of isoprenaline (nonselective BAR agonist) causing half-maximum lipolysis effect (ED50) varied bimodally and 10(6)-fold between individuals but was almost constant in the same subject when measured two times at rest or before and 30 min after exercise. The subjects were categorized as having either high or low isoprenaline sensitivity. The former group had a 50% reduced in vivo lipolytic response to exercise and mental stress, despite a 50% increased plasma noradrenaline response (P < 0.01) and a 350% increased plasma adrenaline response (P < 0.02). In fat cells the lipolytic ED50 values for noradrenaline and terbutaline (BAR2 agonist) were 10 times lower (P < 0.001) in low-sensitive subjects, but the maximum lipolytic actions of these agents (and of isoprenaline) were similar in both groups. The action on lipolysis of dobutamine (BAR1 agonist), forskolin (stimulating adenylate cyclase), dibutyryl cyclic AMP (activating protein kinase), clonidine (alpha 2-adrenergic agonist), or phenyl isopropyladenosine (adenosine receptor agonist) were almost identical in high- and low-sensitivity subjects. ED50 for isoprenaline correlated with ED50 for terbutaline (r = 0.75), but not with ED50 for dobutamine. In high-sensitivity subjects the number of BAR2 was almost three-fold increased (P < 0.002) and the steady-state adipocyte mRNA level for BAR2 was sixfold increased (P < 0.005). BAR2 affinity as well as BAR1 number, affinity and mRNA expression were similar in both groups. In 11 cholecystectomy patients (otherwise healthy) lipolytic ED50 for beta agonists correlated in omental and subcutaneous fat cells (r = 0.85 for isoprenaline; r = 0.95 for terbutaline). In conclusion, lipolytic resistance to catecholamines is present in vivo in apparently healthy subjects due to reduced expression of BAR2 in adipocytes.
TCT-580 Two-Year Real-World Outcomes in 1014 Patients Treated With the Thin-Strut, Platinum-Chromium, Paclitaxel-Eluting TAXUS Element ® Stent: Results From the TE-PROVE European Registry
Authors: Corrado Tamburino, Jim Crowley, Paolo Calabria, Didier Carrié, jacques berland, Jacques Lalmand, Karl-Eugen Hauptmann, Davide Capodanno, Paul Underwood, Keith D. Dawkins
Journal: Journal of the American College of Cardiology (2014)
TCT-16 Incidence, mechanisms and outcome of longitudinal stent deformation (LSD) associated with Element, Resolute, Biomatrix and Xience stents: angiographic and case-by-case review of 1,800 cases.
Authors: Samer Arnous, Nizar Shakhshir, Mamas Mamas, Fath-Ordoubadi Farzin, Andrew Wiper, Karim Ratib, Paul D. Williams, Magdi El-Omar, Douglas G. Fraser
Journal: Journal of the American College of Cardiology (2013)
Thromboxane-Dependent CD40 Ligand Release in Type 2 Diabetes Mellitus
Authors: Francesca Santilli, Giovanni Davì, Agostino Consoli, Francesco Cipollone, Andrea Mezzetti, Angela Falco, Tea Taraborelli, Eleonora Devangelio, Giovanni Ciabattoni, Stefania Basili, Carlo Patrono
Journal: Journal of the American College of Cardiology (2005)
Evaluation of the Tyramine Test In Hypertensive Patients and Controls
Authors: Richard H. Thurm
Journal: JAMA (1966)

Tyramine hydrochloride has been proposed for use as a provocative test for pheochromocytoma. It has been evaluated in 46 hypertensive patients and 58 normotensive controls by members of the US Public Health Service Cooperative Study. Positive tests were obtained preoperatively in two patients with elevated catecholamine and vanilmandelic acid (VMA) levels with proved pheochromocytomas. Seven patients with labile blood pressure responses also had a positive tyramine test. In the latter group, results of catecholamine and VMA determinations were all normal. The tyramine test is a useful and safe addition to the screening procedures in the evaluation of hypertensive patients for remediable causes of elevated blood pressure. Twenty-four-hour urine collections for catecholamine or VMA determinations still are required to confirm the diagnosis of pheochromocytoma.