tbuckley/cabot-search huggingface dataset:
Assessment of Psychopathology
Authors: Carlo Faravelli
Journal: Psychotherapy and Psychosomatics (2004)

Editorials| March 29 2004 Assessment of Psychopathology Subject Area: Psychiatry and Psychology Carlo Faravelli Carlo Faravelli Department of Neurology and Psychiatry, Florence University, and Policlinico Careggi, Florence, Italy Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (2004) 73 (3): 139–141. https://doi.org/10.1159/000076449 Article history Published Online: March 29 2004 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Carlo Faravelli; Assessment of Psychopathology. Psychother Psychosom 1 June 2004; 73 (3): 139–141. https://doi.org/10.1159/000076449 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 2004Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Circulating clonal CLA+ and CD4+ T cells in Sezary syndrome express the skin-homing chemokine receptors CCR4 and CCR10 as well as the lymph node-homing chemokine receptor CCR7
Authors: M. Sokolowska-Wojdylo, J. Wenzel, E. Gaffal, J. Lenz, P. Speuser, S. Erdmann, F. Abuzahra, E. Bowman, J. Roszkiewicz, T. Bieber, T. Tuting
Journal: British Journal of Dermatology (2005)

Adhesion molecules and chemokine receptors are involved in tissue-specific homing of T cells to the skin and play an important role in the pathophysiology of cutaneous lymphoma. It has recently been reported that the chemokine CCL27 expressed by keratinocytes attracts lymphocytes bearing the chemokine receptor CCR10.To investigate the expression of CCR4, CCR7 and CCR10 on skin-homing CLA(+) and CD4(+) T cells in the peripheral blood of patients with Sezary syndrome (SS), a rare leukaemic variant of cutaneous T-cell lymphoma.Lymphocytes from five patients with SS, six patients with mycosis fungoides and four healthy volunteers were isolated and analysed using flow cytometry. Additionally, the T-cell receptor (TCR)-Vbeta CDR3 regions were cloned and sequenced in two patients.We found that CCR4 is expressed on almost all CLA(+) and CD4(+) memory T cells. Using monoclonal antibodies specific for single TCR-Vbeta chains we identified malignant T cells in four patients with SS. Importantly, we found that most but not all malignant Sezary cells expressed the skin-homing chemokine receptor CCR10. Additionally, we found that a significant proportion of these cells also expressed the lymph node-homing chemokine receptor CCR7.Our results support the concept that chemokine receptors play an important role in the pathophysiology of SS and suggest that the malignant clone may represent an expansion of skin-homing cutaneous 'central' memory T cells in the peripheral blood of these patients.
PRIMARY BENIGN AND MALIGNANT MELANOMA OF THE SKIN: WITH A CONSIDERATION OF NORMAL PIGMENT FUNCTION.
Authors: LEE McCARTHY, L. K. McCAFFERTY
Journal: British Journal of Dermatology (1926)

Journal Article PRIMARY BENIGN AND MALIGNANT MELANOMA OF THE SKIN: WITH A CONSIDERATION OF NORMAL PIGMENT FUNCTION. Get access LEE McCARTHY, M.D., LEE McCARTHY, M.D. Washington, D.C Search for other works by this author on: Oxford Academic Google Scholar L. K. McCAFFERTY, M.D. L. K. McCAFFERTY, M.D. New York Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 38, Issue 3, 1 March 1926, Pages 101–112, https://doi.org/10.1111/j.1365-2133.1926.tb09980.x Published: 01 March 1926
Influence of patient characteristics on test ordering in general practice.
Authors: R M Hartley, J R Charlton, C M Harris, B Jarman
Journal: BMJ (1984)

Information regarding all consultations was collected in seven general practices for one year. From these data we report on the use of laboratory tests and its association with patient characteristics--including social class, age, sex, and diagnosis--and with which doctor was consulted. Most of the requests were for technically simple tests of low cost. There was a noticeable variation in the use of tests with regard to all patient characteristics. Diagnosis, identity of doctor, age of patient, and social class were each shown by multivariate techniques to be independently related to use of tests. Whereas fewer tests were used per consultation for social classes III-V compared with other social classes, more were used per patient per year for these same groups, reflecting in part the higher consultation rates of social classes III-V. Variation in diagnoses fully accounted for the greater test ordering for women. Nearly two thirds of all tests were ordered for 10% of all patients who consulted and 7% of all registered patients. The results of our analysis suggest that this concentration is determined primarily by those patient characteristics most indicative of medical need and by which doctor is providing care.
SUDDEN DEATH ASSOCIATED WITH THE INJECTION OF FOREIGN SUBSTANCES
Authors: R. W. LAMSON
Journal: JAMA (1924)

The year 1894 marks the beginning of the use of diphtheria antitoxin in the treatment of diphtheria, though it was not used extensively until several years later. Since 1894, other antiserums have been produced, and other methods of nonspecific and specific protein therapy have been devised. During the last ten years, in consequence, the use of such antiserums and foreign proteins has increased enormously. In the course of this development of serum therapy, some serious and even fatal accidents have been observed. A number of fatal cases have been reported in the literature, and it may rationally be assumed that a certain number have occurred but have never been so reported. The actual number of cases in both groups is generally much overestimated. Only a few attempts have been made to compile and study the records of the reported cases. One of these, by Gottstein,<sup>1</sup>gives a brief summary
Demonstration of histiocytes in the epidermal infiltrate of mycosis fungoides
Authors: F. A. KERDEL, E. W. MORGAN, D. M. MACDONALD
Journal: British Journal of Dermatology (1982)

The presence of histiocytes in the epidermal and dermal infiltrate of mycosis fungoides was observed histochemically by revealing a diffuse pattern of acid alpha-naphthyl acetate esterase (ANAE) activity in the cytoplasm, and immunohistochemically by demonstrating the presence of histiocyte-specific 'enzymes', lysozyme, alpha-I-antitrypsin and alpha-I-antichymotrypsin. Histiocytes in the infiltrate of mycosis fungoides may be involved in antigen processing and interaction with T lymphocytes.
Guideline overload forgets the staff needed to implement them
Authors: Yuen Cheng Looi
Journal: BMJ (2006)

H urrah! We now have a guideline telling us how to recognise malnutrition in our patients. This brings the total number of national guidelines for UK doctors to 300 or more. Out of interest, I had a quick look on the National Institute for Health and Clinical Excellence (NICE) website. With regards to published articles alone, it listed 95 technology appraisals, 156 guidelines on interventional procedures, 41 clinical and cancer services guidelines, as well as 93 health technology assessment reports. There are 13 ongoing consultations, including one inviting comments or suggestions on redesigning the NICE website.

We also have guidelines from the General Medical Council, not to mention the National Service Frameworks. Our colleagues in the north have 85 Scottish Intercollegiate Guidelines Network (SIGN) guidelines as well. There are further guidelines from professional bodies and finally, last but not least, European guidelines such as the European Working Time Directive.

> Some basic things are missing in our rush to shunt patients from one place to another 

The point I wish …
Safety of High-Dose Tricyclic Antidepressant Therapy
Authors: MARC A. SCHUCKIT, JOHN P. FEIGHNER
Journal: American Journal of Psychiatry (1972)

The authors report on a series of depressed inpatients and outpatients who received greater-than-recommended doses of the tricyclic antidepressants for 1,505 patient days. These patients tolerated the drugs with a minimum of side effects and, when tested, showed no evidence of hematologic, hepatic, or ocular damage. The authors give some possible explanations for the individual variations in tolerance and response to this high-dose regimen.
Amantadine's rocky road to acceptance
Authors: Mitchel L. ZOLER
Journal: JAMA (1983)

When amantadine hydrochloride was first licensed by the Food and Drug Administration in 1966, it was specified for prophylaxis of Asian influenza. Many who have watched amantadine's tortuous path to widespread acceptance believe a basic problem lay in this initial licensing. "Soon after the approval," recalls Marvin Paulshock, PhD, associate director of clinical research, Biochemicals Department, the DuPont Company, "influenza underwent an antigen shift and we had the Hong Kong flu epidemic of 1968. The FDA decided that amantadine could not be promoted for Hong Kong influenza before its clinical effectiveness was proved. DuPont was able to show that the Hong Kong strain was inhibited by amantadine in vitro and in mice, but no clinical trials were established. We realized that we could never catch up—each time a trial would be completed, a new antigenic variant would have appeared." Instead, DuPont waited while researchers abroad and in the United States
The casualties of Waugh
Authors: Theodore Dalrymple
Journal: BMJ (2007)

My father was not very good at telling jokes. If something was a fact he couldn't leave it out, and over-inclusiveness is not an aid to mirth. Still, he had a repertoire of old favourites, and one of them, which he told many times, concerned what in those days was still popularly known as the loony bin.

An inmate showed the chairman of the board of visitors around the establishment, and did so with such lucidity that the chairman asked him why he was an inmate at all. He replied that he didn't know, and asked the chairman to help him secure his release. The chairman promised to do so. …
Abstract 5603: Impact of combination of PSK with TGF-beta inhibitor on anti-tumor immunity
Authors: Tanaka Hiroaki, Sadaaki Yamazoe, Takehiko Iwauchi, Kazuya Muguruma, Naoshi Kubo, Yukihiro Kato, Junya Morimoto, Shinichiro Kashiwagi, Yuhiko Fuyuhiro, Eiji Noda, Ryosuke Amano, Toru Inoue, Nobuya Yamada, Kiyoshi Maeda, Masaichi Ohira, Kosei Hirakawa
Journal: Cancer Research (2010)

Abstract The transforming growth factor-β (TGF-β) has a role in tumor progression and metastasis. Secretion of TGF-β by tumor cells also suppresses an antitumor immune response in which dendritic cells (DCs) play an important role to activate cytotoxic T lymphocytes (CTLs). Here we report that small molecule TGF-β signaling inhibitor, SB-431542 (SB), induce DC maturation in vitro when combined with Protein-bound polysaccharide K (PSK). PSK has been used clinically as an anti-tumor agent in Japan. It has been reported that PSK have potential to induce anti-tumor immune response. In this study, we examined the impact of PSK and SB-431542 on maturation of DCs under immunological tolerant status. At first, we added SB and PSK to cultures of human DCs generated from peripheral monocytes in the presence of TGF-β and examined expression of CD83, production of Interleukin-12 (IL-12) and capacity of DCs to induce T cell proliferation. SB-431542 with PSK induced upregulation of CD83 of human DCs and improved their abilities to produce interleukin 12. They also augmented capacity of human DCs to activate naïve T cells in allogeneic mixed lymphocyte reaction. These results suggested that TGF-β receptor I kinase inhibitor such as SB-431542 should be able to induce antitumor immune response in immuno-tolerant patients associated with TGF-β activity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5603.
Biliary copper excretion by hepatocyte lysosomes in the rat. Major excretory pathway in experimental copper overload.
Authors: J B Gross, B M Myers, L J Kost, S M Kuntz, N F LaRusso
Journal: Journal of Clinical Investigation (1989)

We investigated the hypothesis that lysosomes are the main source of biliary copper in conditions of hepatic copper overload. We used a rat model of oral copper loading and studied the relationship between the biliary output of copper and lysosomal hydrolases. Male Sprague-Dawley rats were given tap water with or without 0.125% copper acetate for up to 36 wk. Copper loading produced a 23-fold increase in the hepatic copper concentration and a 30-65% increase in hepatic lysosomal enzyme activity. Acid phosphatase histochemistry showed that copper-loaded livers contained an increased number of hepatocyte lysosomes; increased copper concentration of these organelles was confirmed directly by both x ray microanalysis and tissue fractionation. The copper-loaded rats showed a 16-fold increase in biliary copper output and a 50-300% increase in biliary lysosomal enzyme output. In the basal state, excretory profiles over time were similar for biliary outputs of lysosomal enzymes and copper in the copper-loaded animals but not in controls. After pharmacologic stimulation of lysosomal exocytosis, biliary outputs of copper and lysosomal hydrolases in the copper-loaded animals remained coupled: injection of colchicine or vinblastine produced an acute rise in the biliary output of both lysosomal enzymes and copper to 150-250% of baseline rates. After these same drugs, control animals showed only the expected increase in lysosomal enzyme output without a corresponding increase in copper output. We conclude that the hepatocyte responds to an increased copper load by sequestering excess copper in an increased number of lysosomes that then empty their contents directly into bile. The results provide direct evidence that exocytosis of lysosomal contents into biliary canaliculi is the major mechanism for biliary copper excretion in hepatic copper overload.
CloudNMF: A MapReduce Implementation of Nonnegative Matrix Factorization for Large-Scale Biological Datasets
Authors: Ruiqi Liao, Yifan Zhang, Jihong Guan, Shuigeng Zhou
Journal: Genomics Proteomics & Bioinformatics (2013)

Abstract In the past decades, advances in high-throughput technologies have led to the generation of huge amounts of biological data that require analysis and interpretation. Recently, nonnegative matrix factorization (NMF) has been introduced as an efficient way to reduce the complexity of data as well as to interpret them, and has been applied to various fields of biological research. In this paper, we present CloudNMF, a distributed open-source implementation of NMF on a MapReduce framework. Experimental evaluation demonstrated that CloudNMF is scalable and can be used to deal with huge amounts of data, which may enable various kinds of a high-throughput biological data analysis in the cloud. CloudNMF is freely accessible at http://admis.fudan.edu.cn/projects/CloudNMF.html.
The Medical Directive
Authors: Greg A. Sachs, Christine K. Cassel
Journal: JAMA (1990)

<h3>To the Editor.—</h3> We were disappointed by the article entitled "The Medical Directive: A New Comprehensive Advance Care Document"<sup>1</sup>for three reasons: (1) it states assumptions about the underuse of current advance directives that are not substantiated by any data, (2) it ignores standard methods for developing and testing new instruments, and (3) it claims to reduce uncertainty by using a complicated form that itself contains a great deal of uncertainty. In a recent<i>JAMA</i>editorial, Dr Pelligrino<sup>2</sup>wrote of the "unsubstantiated assumptions" that had often been made when ethics research was carried out only in libraries. Drs Emanuel and Emanuel seem to continue this unfortunate tradition with their Medical Directive. First, the authors assume that the living will and durable power of attorney for health care are underused, in part, because of "linguistic vagueness," the lack of a "range of possible clinical circumstances," and the lack of
Nortriptyline Hydrochloride Overdosage
Authors: James L. Stinnett
Journal: JAMA (1968)

In an attempt at suicide, a 25-year-old woman took an overdose of nortriptyline hydrochloride. She became hypotensive, comatose, and her respiration rate was depressed. The electrocardiogram showed a lengthened P-R interval. The clinical state cycled between central nervous system depression and lightening of the level of consciousness. Treatment consisted of gastric lavage, supportive therapy, and osmotic diuresis. It is suggested that osmotic diuresis or dialysis may be ineffective. Use of pyridostigmine bromide may be considered for serious ECG changes.
Quantitative analysis of mononuclear cells expressing human immunodeficiency virus type 1 RNA in esophageal mucosa.
Authors: P D Smith, C H Fox, H Masur, H S Winter, D W Alling
Journal: The Journal of Experimental Medicine (1994)

The mucosa of the gastrointestinal tract is presumably an important reservoir for human immunodeficiency virus type 1 (HIV-1), but the level of virus-expressing cells within the mucosa of infected patients is not known. To study this issue, we identified HIV-1 mRNA-expressing (positive) mononuclear cells by in situ hybridization in specimens of esophageal mucosa from eight patients with acquired immune deficiency syndrome (AIDS) and esophageal infections. Such cells were not found in four patients with AIDS and no esophageal disease. Immunocytochemical staining revealed that the mononuclear cells expressing HIV-1 mRNA were lamina propria macrophages. The prevalence of positive cells was measured by triplicate determinations in each of three experiments using an inverse sampling technique. No significant differences in prevalence were found among patients or among experiments. The overall prevalence of HIV-1 mRNA-expressing cells in the esophageal lamina propria was 0.059 +/- 0.01%. This prevalence of cells expressing HIV-1 mRNA in the mucosa of patients with mucosal infections may reflect the local abundance of stimuli such as bacterial endotoxin and certain cytokines capable of inducing viral transcription.
Simultaneous occurrence of two rare cutaneous markers of poor prognosis in myelodysplastic syndrome: erythema elevatum diutinum and specific lesions
Authors: S. ARACTINGI, C. BACHMEYER, H. DOMBRET, D. VIGNON-PENNAMEN, L. DEGOS, L. DUBERTRET
Journal: British Journal of Dermatology (1994)

Summary We report the concomitant occurrence of erythema elevatum diutinum and specific skin lesions in a patient with a myelodysplastic syndrome (MDS). This patient's course, and review of other reported cases, support the opinion that neutrophilic dermatoses are associated with a poor prognosis of MDS. The simultaneous appearance of these manifestations could be the consequence of a particular chemotactism of myeloid cells, expressed after acute transformation.
Pathogenesis of NIDDM in Pima Indians
Authors: Clifton Bogardus, Stephen Lillioja, Peter H Bennett
Journal: Diabetes Care (1991)

The Pima Indians of Arizona have the highest reported prevalence and incidence of non-insulin-dependent diabetes mellitus (NIDDM) of any population in the world. A cross-sectional and longitudinal study was begun in 1982 to determine the metabolic characteristic(s) that is (are) predictive of the development of NIDDM and to document the sequence of metabolic events that occur with the transition from normal to impaired glucose tolerance and then to diabetes. Preliminary analyses suggest that insulin resistance is a primary abnormality predisposing Pima Indians to develop impaired glucose tolerance, and that the development of diabetes occurs with subsequent pancreatic failure.
Significance of Cord-Blood Leptin in Newborns of Diabetic Mothers
Authors: Sylvie Hiéronimus, Stéphanie Bastard, Jean-Yves Gillet, Jean Giudicelli, Françoise Brucker-Davis, Frédéric Berthier, Emmanuel Van Obberghen, Patrick Fénichel
Journal: Diabetes Care (2002)

Human fetal adipocyte produces leptin. At birth, cord-blood leptin concentration closely correlates with the amount of newborn fat mass. It is suggested that the sexual dimorphism observed in adults already exists in utero. The higher leptin levels in newborns of diabetic mothers (1) compared with the offspring of nondiabetic mothers could reflect increased adipose tissue. It has also been postulated that hypoxic conditions during pre-eclamspsia affect cord-blood leptin (2) and that fetal insulin stimulates fetal adipocyte leptin production (3).

We assessed cord-blood levels of leptin and insulin in …
A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis
Authors: Takashi Sasaki, Aiko Shiohama, Akiharu Kubo, Hiroshi Kawasaki, Akemi Ishida-Yamamoto, Taketo Yamada, Takayuki Hachiya, Atsushi Shimizu, Hideyuki Okano, Jun Kudoh, Masayuki Amagai
Journal: Journal of Allergy and Clinical Immunology (2013)
Staging Hepatocellular Carcinoma by a Novel Scoring System (BALAD Score) Based on Serum Markers
Authors: Hidenori Toyoda, Takashi Kumada, Yukio Osaki, Hiroko Oka, Fumihiro Urano, Masatoshi Kudo, Takashi Matsunaga
Journal: Clinical Gastroenterology and Hepatology (2006)