tbuckley/cabot-search huggingface dataset:
The fate of trenbolone acetate and melengestrol acetate after application as growth promoters in cattle: environmental studies.
Authors: B Schiffer, A Daxenberger, K Meyer, H H Meyer
Journal: Environmental Health Perspectives (2001)

The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to determine the residues and degradation of trenbolone and MGA in solid dung, liquid manure, and soil. In animal experiments lasting 8 weeks, cattle were treated with TbA and MGA. Solid dung and, in case of trenbolone, liquid manure were collected and spread on maize fields after 4.5 and 5.5 months of storage, respectively. Determination of the hormone residues in all samples included extraction, clean-up (solid-phase extraction), separation of metabolites and interfering substances by HPLC (RP-18), and quantification by sensitive enzyme immunoassay. Procedures were validated by mass spectrometry (MS) methods. During storage of liquid manure the level of trenbolone decreased from 1,700 to 1,100 pg/g (17alpha-isomer), corresponding to a half-life of 267 days. Before storage, the concentrations in the dung hill ranged from 5 to 75 ng/g TbOH and from 0.3 to 8 ng/g MGA. After storage, levels up to 10 ng/g trenbolone, and 6 ng/g MGA were detected. In the soil samples trenbolone was traceable up to 8 weeks after fertilization, and MGA was detected even until the end of the cultivation period. The results show that these substances should be investigated further concerning their potential endocrine-disrupting activity in agricultural ecosystems.
Safety of Concomitant Administration of Seasonal and/or H1N1 Flu Vaccination in Patients Receiving Erlotinib for Advanced Non-small Cell Lung Cancer
Authors: Gianluca Spitaleri, Angelo Delmonte, Francesca Toffalorio, Tommaso Martino De Pas, Vanesa Gregorc
Journal: Journal of Thoracic Oncology (2010)
HTLV-1 p12I protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells
Authors: Christophe Nicot, James C. Mulloy, Maria G. Ferrari, Julie M. Johnson, Kaisong Fu, Risaku Fukumoto, Raffaella Trovato, Jake Fullen, Warren J. Leonard, Genoveffa Franchini
Journal: Blood (2001)
Ethics in Medical Progress: With Special Reference to Transplantation
Authors: Belding H. Scribner
Journal: JAMA (1967)

The Ciba symposium on<i>Ethics in Medical Progress</i>is helpful reading for any physician who has pondered the dilemma of stopping parenteral therapy in a dying cancer patient or who has tried to find treatment for a patient with end-stage kidney disease. Although intentionally limited in scope to the ethics of organ transplantation, the book covers many interrelated subjects, such as euthanasia and the definition of death, and the reader is given a broad perspective on many current and future ethical problems in medicine that seem destined to challenge some of the basic tenets of our society. The symposium consists of a series of short and very provocative papers followed by discussions by physicians, lawyers, and theologians. The discussions are well edited and to the point. Because of the international composition of the symposium, interesting differences in ethical and practical approaches to problems emerge. For example, it was of interest
Doctors, let's stop dragging (our feet)
Authors: William A. Check
Journal: JAMA (1979)

In January of this year, on the 15th anniversary of the first Surgeon General's report on smoking and health, the Department of Health, Education, and Welfare issued a 1,200-page update concluding that cigarette smoking is a major factor in 345,000 deaths each year due to cancer and heart and lung disease. In November, the American Cancer Society (ACS) reported that lung cancer had become the second leading cancer killer among women. "As more women took up smoking, the lung cancer death rate tripled since 1965," said the ACS. These statistics doubtless will provide sufficient motivation for some smokers to stop. Yet, fully 30 million smokers have tried to kick the addiction and failed, according to a 1975 survey commissioned by the Center for Disease Control in Atlanta. Many of these would-be nonsmokers have discovered that quitting smoking, like dancing the tango, is hard to do by yourself. Among the numerous
Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency
Authors: Stéphanie Dupuis, Emmanuelle Jouanguy, Sami Al-Hajjar, Claire Fieschi, Ibrahim Zaid Al-Mohsen, Suliman Al-Jumaah, Kun Yang, Ariane Chapgier, Céline Eidenschenk, Pierre Eid, Abdulaziz Al Ghonaium, Haysam Tufenkeji, Husn Frayha, Suleiman Al-Gazlan, Hassan Al-Rayes, Robert D. Schreiber, Ion Gresser, Jean-Laurent Casanova
Journal: Nature Genetics (2003)
Air Pollution in New Guinea
Authors: Kenneth M. Master
Journal: JAMA (1974)

Inhabitants of villages in the Highlands of New Guinea wear scant clothing. To keep warm during cold nights they burn smoky fires in small closed huts, where they inhale extremely high levels of particulate matter and aldehydes. Pulmonary disease, mainly obstructive but also restrictive, appears at an early age and was present in 78% of subjects over age 40 years. Severely affected subjects have diminished breath sounds, coarse rales, and decreased chest cage movement. Pathologic specimens from affected subjects demonstrated centrilobular emphysema, thickened pleura, pulmonary fibrosis, mucous gland hypertrophy, and deposition of anthracotic pigment. Other factors probably responsible for the high prevalence of pulmonary disease include smoking of home grown tobacco, protein malnutrition, poor sanitation, and various endemic diseases. (<i>JAMA</i>228:1653-1655, 1974)
Association of Type B Insulin Resistance and Type 1 Diabetes Resulting in Ketoacidosis
Authors: Olivier Bourron, Corinne Vigouroux, Marine Halbron, Elia Belle Touati, Emilie Capel, Martine Caron-Debarle, Agnès Hartemann
Journal: Diabetes Care (2012)

Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of autoantibodies directed against the insulin receptor, resulting in a marked IR inducing hyperglycemia (1,2). We describe here what we believe to be a case of type 1 diabetes and ketoacidosis associated with type B IR syndrome.

A 55-year-old Caucasian European man with mild obesity (BMI 32.4 kg/m2) was diagnosed as having type 2 diabetes. Insulin therapy was introduced after 3 years of oral antidiabetic therapy when weight loss suggested lack of insulin secretion. Four years after diagnosis, he developed a severe metabolic ketoacidosis. Continuous insulin infusion was promptly introduced, but ketones disappeared only after 6 days. Insulin requirement was exceptionally high (up to 5 units/kg/day …
Textbook of obstetrics and obstetric nursing
Authors: Irwin H. Kaiser
Journal: JAMA (1963)

Since this textbook, specifically directed to nurses, is in its fourth edition 14 years after its first appearance, it may be considered to be successful. It is distressing, therefore, to find it replete with inaccuracies (eg, diuril prevents gastrointestinal absorption of sodium); inconsistencies (eg, differing incidences of home delivery, on pp 291 and 318 ); anachronisms (eg, heart disease as an indication for cesarean section ); pointless repetition ( eg, three x-ray photographs of anencephaly, two identical); and triviality (eg, "For the comfort of the patient and to prevent burns the [perineal flush] water should not be too hot."). What is of greater concern, however, is the general tone of the book, which might be characterized as both superficial and folksy. In discussing the use of chloroform, for example, the authors state that it can cause "suspended animation," when they mean death, and they advise that the drug be given with "prayer." They
34 Detectable HBV-specific T cell responses in liver transplant recipients: A comparison to chronic hepatitis B
Authors: E. Loggi, F.K. Bihl, J.V. Chisholm, L. Testa, C. Cursaro, M. Biselli, A.D. Pinna, M. Bernardi, C. Brander, P. Andreone
Journal: Journal of Hepatology (2006)
Anthropometric and training variables related to 10km running performance.
Authors: P Bale, D Bradbury, E Colley
Journal: British Journal of Sports Medicine (1986)

Sixty male distance athletes were divided into three equal groups according to their personal best time for the 10km run. The runners were measured anthropometrically and each runner completed a detailed questionnaire on his athletic status, training programme and performance. The runners in this study had similar anthropometric and training profiles to other distance runners of a similar standard. The most able runners were shorter and lighter than those in the other two groups and significantly smaller skinfold values (P less than 0.05). There were no significant differences between the groups for either bone widths or circumferences but the elite and good runners had significantly higher ponderal indices (P less than 0.05) than the average runners, indicating that they are more linear. Elite and good runners were also less endomorphic but more ectomorphic than the average runners. The elite runners trained more often, ran more miles per week and had been running longer (P less than 0.05) than good or average runners. A multiple regression and discriminant function analysis indicated that linearity, total skinfold, the type and frequency of training and the number of years running were the best predictors of running performance and success at the 10km distance.
Mesenteric Circulation in Hemorrhagic Shock
Authors: JULIUS J. FRIEDMAN
Journal: Circulation Research (1961)

The effect of hemorrhage and of reinfusion on the mesenteric circulation of dogs was determined. During the control period, the average mesenteric vascular resistance was 0.6 P.R.U., and the average mesenteric plasma volume was 100 ml. Hemorrhagc produced an early reduction in mesenteric plasma volume, averaging 50 per cent, without any accompanying change in mesenteric vascular resistance. As the hemorrhagie period progressed, mesenteric vascular resistance rose to a level 120 per cent above control coincidental with the autoinfusion of blood from the hemorrhagc reservoir. With the elevation in mesenteric vascular resistance, mesenteric plasma volume displayed a slight additional decline. Reinfusion produced only a slight and transient recovery of mesenteric vascular resistance and plasma volume. A comparison of mesenteric vascular resistance changes with those of mesenteric plasma volume indicates that no uniform relationship exists. Similar dissociation was seen between mesenteric plasma volume and portal venous pressure. No evidence of pooling of blood in the mesenteric circulation during the induction and development of normovolemic hemorrhagie shock was observed.
Abstract B03: Stromal cells confer drug resistance to breast cancer cells in a kinetic co-culture model
Authors: Katherine Artymovich, Clare Szybut, Kalpana Patel, Tim O'Callaghan, Tim Dale, Del Trezise, Daniel M. Appledorn
Journal: Cancer Research (2013)

Abstract The tumor microenvironment is fundamentally involved in the response of a tumor to anti-cancer therapies. In this study, we present a novel method for kinetically measuring the proliferation of one or more cell types in mixed, co-culture models. Specifically, lentiviral based reagents are used to label nuclei of multiple cell populations within a single culture. Real time cell counts are acquired using an automated, Live Content Imaging approach in which 96-well and 384-well microplates are imaged every 2-3 hours over the course of the full 2-3 day assay. Using this strategy, we confirm data illustrating that culturing HER-2 positive breast cancer cells (SK-BR-3) in the presence of either Human Mammary Fibroblasts (HMFs) or normal skin fibroblasts (CCD-1068Sk) are resistant to the anti-proliferative and cytotoxic effects of the HER-2 and EGFR tyrosine kinase inhibitor lapatinib. Extending this data, we also completed pharmacolgical analyses, using area under the curve of the full kinetic trace, revealing nearly a 2-log difference in lapatinib sensitivity between SK-BR-3 cells grown in the presence or absence lapatinib. The data presented here reveal a novel, automated, kinetic assay for measuring proliferation of one or more cell types in mixed culture models. More importantly, these data further clarify the pharmacolgical effect stromal cells can have on the resistance of breast cancer cells to lapatinib treatment. Citation Format: Katherine Artymovich, Clare Szybut, Kalpana Patel, Tim O'Callaghan, Tim Dale, Del Trezise, Daniel M. Appledorn. Stromal cells confer drug resistance to breast cancer cells in a kinetic co-culture model. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr B03.
A piece of my mind. The learning curve
Authors: B. Gaster
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antioxidant and other biological activities of phenols from olives and olive oil
Authors: Francesco Visioli, Andrea Poli, Claudio Gall
Journal: Medicinal Research Reviews (2001)

Abstract Olive oil is the principal source of fats in the Mediterranean diet, which has been associated with a lower incidence of coronary heart disease and certain cancers. Phenolic compounds, e.g., hydroxytyrosol and oleuropein, in extra‐virgin olive oil are responsible for its peculiar pungent taste and for its high stability. Recent findings demonstrate that olive oil phenolics are powerful antioxidants, both in vitro and in vivo , and possess other potent biological activities that could partially account for the observed healthful effects of the Mediterranean diet. © 2001 John Wiley &amp; Sons, Inc. Med Res Rev, 22, No. 1, 65–75, 2002
Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system.
Authors: F J Branicki, D F Evans, A L Ogilvie, M Atkinson, J D Hardcastle
Journal: Gut (1982)

Gastro-oesophageal reflux has been assessed in 10 symptomatic patients and 10 asymptomatic normal subjects during a study period of 24 hours at work and in the home using a newly developed pH sensitive radiotelemetry capsule and a portable receiving system. Oesophageal pH was continuously monitored by the tethered radiotelemetry capsule and recorded with a portable receiver and a 24-hour cassette recorder, allowing the patient complete freedom of movement so that ambulatory studies could be undertaken during a normal working day. The number and duration of reflux episodes was greater in symptomatic patients than normal subjects during 24-hour studies at home (p less than 0.002). In both groups, reflux occurred more during the day than at night (p less than 0.01). Patients refluxed significantly more at home than when they were in hospital (p less than 0.01). Ambulatory outpatient oesophageal pH monitoring may be useful in the management of patients with atypical symptoms and may demonstrate significant reflux when inpatient investigations and endoscopy findings show minimal abnormality.
VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats
Authors: Yang Li, Fan Zhang, Nobuo Nagai, Zhongshu Tang, Shuihua Zhang, Pierre Scotney, Johan Lennartsson, Chaoyong Zhu, Yi Qu, Changge Fang, Jianyuan Hua, Osamu Matsuo, Guo-Hua Fong, Hao Ding, Yihai Cao, Kevin G. Becker, Andrew Nash, Carl-Henrik Heldin, Xuri Li
Journal: Journal of Clinical Investigation (2008)

Despite its early discovery and high sequence homology to the other VEGF family members, the biological functions of VEGF-B remain poorly understood. We revealed here a novel function for VEGF-B as a potent inhibitor of apoptosis. Using gene expression profiling of mouse primary aortic smooth muscle cells, and confirming the results by real-time PCR using mouse and rat cell lines, we showed that VEGF-B inhibited the expression of genes encoding the proapoptotic BH3-only proteins and other apoptosis- and cell death–related proteins, including p53 and members of the caspase family, via activation of VEGFR-1. Consistent with this, VEGF-B treatment rescued neurons from apoptosis in the retina and brain in mouse models of ocular neurodegenerative disorders and stroke, respectively. Interestingly, VEGF-B treatment at the dose effective for neuronal survival did not cause retinal neovascularization, suggesting that VEGF-B is the first member of the VEGF family that has a potent antiapoptotic effect while lacking a general angiogenic activity. These findings indicate that VEGF-B may potentially offer a new therapeutic option for the treatment of neurodegenerative diseases.
NEW ETIOLOGICAL FACTOR IN ECTOPIC PREGNANCY
Authors: Leon Krohn
Journal: JAMA (1952)

In accepting the benefits of recent advances in the treatment of a disease, the clinician must be thoroughly acquainted not only with the favorable alterations in the clinical course of the condition under treatment but with the undesirable sequelae as well. Since the advent of antibiotics, particularly penicillin, the clinical course of infections of the female pelvic organs has radically changed. The number of patients who have been spared surgery or invalidism is gratifying. Most patients with acute salpingitis or acute postabortal infections, if treated early with penicillin, are left with little or no residual damage. Thus, the incidence of sterility following these infections has been reduced considerably. Several years ago we reported results of the use of intramuscularly administered penicillin in the treatment of a series of patients with chronic endocervicitis. 1 At that time definite improvement was noted in 94.5% of the patients. More recently the response to
HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism
Authors: Takakazu Kawase, Keitaro Matsuo, Koichi Kashiwase, Hidetoshi Inoko, Hiroh Saji, Seishi Ogawa, Shunichi Kato, Takehiko Sasazuki, Yoshihisa Kodera, Yasuo Morishima
Journal: Blood (2008)
Stat3 in Thymic Epithelial Cells Is Essential for Postnatal Maintenance of Thymic Architecture and Thymocyte Survival
Authors: Shigetoshi Sano, Yousuke Takahama, Takehiko Sugawara, Hiroshi Kosaka, Satoshi Itami, Kunihiko Yoshikawa, Jun-ichi Miyazaki, Willem van Ewijk, Junji Takeda
Journal: Immunity (2001)
Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo
Authors: Nicole K. Paulk, Karsten Wursthorn, Zhongya Wang, Milton J. Finegold, Mark A. Kay, Markus Grompe
Journal: Hepatology (2009)

Adeno-associated virus (AAV) vectors are ideal for performing gene repair due to their ability to target multiple different genomic loci, low immunogenicity, capability to achieve targeted and stable expression through integration, and low mutagenic and oncogenic potential. However, many handicaps to gene repair therapy remain. Most notable is the low frequency of correction in vivo. To date, this frequency is too low to be of therapeutic value for any disease. To address this, a point-mutation–based mouse model of the metabolic disease hereditary tyrosinemia type I was used to test whether targeted AAV integration by homologous recombination could achieve high-level stable gene repair in vivo. Both neonatal and adult mice were treated with AAV serotypes 2 and 8 carrying a wild-type genomic sequence for repairing the mutated Fah (fumarylacetoacetate hydrolase) gene. Hepatic gene repair was quantified by immunohistochemistry and supported with reverse transcription polymerase chain reaction and serology for functional correction parameters. Successful gene repair was observed with both serotypes but was more efficient with AAV8. Correction frequencies of up to 10−3 were achieved and highly reproducible within typical dose ranges. In this model, repaired hepatocytes have a selective growth advantage and are thus able to proliferate to efficiently repopulate mutant livers and cure the underlying metabolic disease. Conclusion: AAV-mediated gene repair is feasible in vivo and can functionally correct an appropriate selection-based metabolic liver disease in both adults and neonates. (HEPATOLOGY 2010.)
Dynamism of a Human Body
Authors: Janet M. Torpy
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MECHANICAL FEATURES IN OBLIQUE FRACTURES.
Authors: J. E. OWENS
Journal: JAMA (1898)

The mechanical features of fractures in general and oblique fractures in particular are apparent from almost every standpoint. The derivation of the word implies the mechanical nature of the injury. The oblique fracture is always the result of some local strain or injury, varying from a slight to a strong muscular effort or of severe external violence. Whether the local cause be from external violences or muscular action, it is mechanical in nature and that, too, whether the bone gives away at the part struck by direct violence or at its weakest part by compression between two opposing forces, as in fracture by indirect violence. Oblique fractures are prone to cause laceration of the skin by their sharp extremities, rendering the fracture compound. This occurs much more frequently than in the case of transverse fractures. A variety of complications may result mechanically from the sharp ends of the broken bones