tbuckley/cabot-search huggingface dataset:
Is there room for simple links in a propositional mind?
Authors: Evan J. Livesey, Justin A. Harris
Journal: Behavioral and Brain Sciences (2009)

Abstract Against Mitchell et al.'s assertions, we argue that (1) the concordance between learning and awareness does not support any particular learning theory, (2) their propositional approach is at odds with examples of learned behaviours that contradict beliefs about causation, and (3) the relative virtues of the two approaches in terms of parsimony is more ambiguous than Mitchell et al. suggest.
Smoking and Lung Cancer
Authors: Jesse L. Steinfeld
Journal: JAMA (1985)

DR EVARTS Graham and his colleague, senior medical student Ernest Wynder, published the results of their collaborative epidemiologic studies in the<i>Journal of the American Medical Association</i>about the time of Mr Wynder's graduation as a physician. The article, "Tobacco Smoking as a Possible Etiologic Factor in Bronchiogenic Carcinoma," was a seminal article in 1950 for a number of reasons. It was the largest retrospective study on tobacco smoking conducted up to that time. It incorporated patients from many centers, thus obviating the criticism that a particular group of adults were subject to a unique, unknown exposure in a defined geographic region, thereby confounding the results. It established standards for retrospective studies, which included a successful technique for quantifying the number of cigarettes (plus cigars and pipesful of tobacco) consumed, the number of years of smoking, the age at which smoking began, and the brand of cigarettes smoked (although such
Hematopoietic cell transplantation for primary plasma cell leukemia: results from the Center for International Blood and Marrow Transplant Research
Authors: A Mahindra, M E Kalaycio, J Vela-Ojeda, D H Vesole, M-J Zhang, P Li, J R Berenson, J M Bird, A Dispenzieri, J L Gajewski, R P Gale, L Holmberg, S Kumar, R A Kyle, H M Lazarus, S Lonial, J Mikhael, G A Milone, R Munker, R Nath, S Saccaro, L Bik To, D T Vogl, B Wirk, P Hari
Journal: Leukemia (2011)
DOES TIMING OF LASIX ADMINISTRATION AFFECT PATIENT ABILITY TO TOLERATE DIURETIC RENOGRAPHY?
Authors: Y Liu, L S Zuckier, N V Ghesani
Journal: Clinical Nuclear Medicine (2005)

Greater New York and New England Chapters, the Society of Nuclear Medicine 18th Annual Northeast Regional Scientific Session Abstracts October 22–October 24, 2004—Stamford, Connecticut: PDF Only
EXAGGERATED BLOOD PRESSURE RESPONSE IS ACCOMPANIED BY A STATE OF PRONOUNCED ALBUMINURIA, HYPOADIPONECTINEMIA, INCREASED ASYMMETRIC DIMETHYLARGININE AND OSTEOPROTEGERIN LEVELS IN HYPERTENSION
Authors: Konstantinos P. Tsioufis, Kyriakos Dimitriadis, Anastasia Mazaraki, Eirini Andrikou, Ioannis Andrikou, Athanasios Aggelis, Antigoni Miliou, Andreas Michaelides, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2010)
Diagnosis of Hypertrophic Subaortic Stenosis with a Doppler Velocity Flow Detector
Authors: CLAUDE R. JOYNER
Journal: Annals of Internal Medicine (1971)

A transcutaneous Doppler velocity probe was used to record phasic carotid artery flow in 12 patients with hypertrophic subaortic stenosis. In contrast to the normal Doppler flow pattern of a single large orthograde systolic wave, all patients demonstrated a distinctively abnormal flow profile. A sharp wave of rapid, early systolic flow was followed by an abrupt decrease of flow in midsystole with a slower phase of late systolic flow. In 4 of the 12 patients the distinctively abnormal Doppler flow pattern was found in the absence of the characteristic sharp percussion and low tidal wave carotid pulse contour often present in hypertrophic subaortic stenosis. The Doppler recording of phasic carotid flow seems valid for the clinical evaluation of this disease, since the abnormal abrupt decrease in midsystolic flow was not found in the study of 94 patients presenting with other cardiovascular disease.
False Positive Phencyclidine Results Caused by Venlafaxine
Authors: PATRICIO MOLERO SANTOS, PILAR LÓPEZ-GARCÍA, JAVIER SCHLATTER NAVARRO, ANTONIO SEVA FERNÁNDEZ, BELÉN SÁDABA, JORGE PLA VIDAL
Journal: American Journal of Psychiatry (2007)

case of evaluated mirtazapine levels in breastmilk at the time of expected maximum postdose plasma levels under the assumption that breastmilk levels peak at similar timepoints.A 35-year-old, 60 kg, primiparous, breastfeeding woman who was prescribed mirtazapine (22.5 mg/day) approached our outpatient service for concerns about her 6-week-old child`s possible exposure to mirtazapine through her breastmilk.After description of the study procedure to the patient, written informed consent was obtained for herself and her child.We examined breastmilk levels following 14 days of mirtazapine therapy to ensure that steady state was reached.At the time of assessment, the mother was breastfeeding exclusively.Breastmilk was collected at 4 and 10 hours postdose, foremilk and hindmilk were collected separately.Because of nighttime medication intake, maternal and infant plasma could not be obtained until 12.5 hours postdose.Mirtazapine levels (mass transition, 266 >165) were determined by tandem mass spectrometry, as described previously (2), with an interday imprecision of 12%.Mass transition characterizes the mirtazapine molecule.In tandem mass spectrometry, the mother molecule is broken into fragments, and 165dalton fragment is taken to characterize and quantify mirtazapine.Although considerably higher levels were found in the milk 4 hours postdose (130 ng/ml foremilk, 145 ng/ ml hindmilk) compared with 10 hours postdose (61ng/ml foremilk, 90ng/ml hindmilk), the weight-adjusted maternal dose was still relatively low, ranging from 3.9%-4.4% at 4 hours to 1.8%-2.7%at 10 hours.Infant plasma levels were not detectable at 12.5 hours postdose.Weekly follow-ups showed no abnormalities of the infant, especially regarding sedation or weight gain.The infant's weight at 6 months was 6.3 kg, i.e. consistently below the 25 percentile even before mirtazapine therapy.
Philosophy on Trial: Examining Ethics of Clinical Investigations
Authors: Charles Marwick
Journal: JAMA (1988)

THE PARAMOUNT ETHICAL questions posed by any clinical trial include the following: Should it be done at all? What information will be elicited that is not now available? Is seeking to obtain this information justifiable in terms of the risks to the subjects that may be involved? In the view of John Fletcher, PhD, these questions override all other considerations in the protection of human subjects, including the much-publicized one of informed consent. Before going to the University of Virginia School of Medicine, Charlottesville, where he is professor of biomedical ethics, Fletcher was the resident bioethicist at the Clinical Center of the National Institutes of Health (NIH), Bethesda, Md—the first person to hold the post. Fletcher became interested in the ethical aspects of medical research when he was a student at Union Theological Seminary in New York City, where he received his doctorate. During that period, he worked as a
Health Risks in Pakistan
Authors: Joan Stephenson
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of influenza in Hanoi, Vietnam, from 2001 to 2003
Authors: Hang L.K. Nguyen, Reiko Saito, Ha K. Ngiem, Makoto Nishikawa, Yugo Shobugawa, Doan C. Nguyen, Long T. Hoang, Lien P. Huynh, Hiroshi Suzuki
Journal: Journal of Infection (2007)
A piece of my mind. Diagnosis: V65.5
Authors: A. Yared
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Force patterns of hypoxic myocardium applied to oxygenated muscle preparations: comparison with effects of regional ischemia on the contraction of non-ischemic myocardium
Authors: G SHIMIZU, A WIEGNER, W GAASCH, C CONRAD, A CICOGNA, O BING
Journal: Cardiovascular Research (1996)

Objective: To examine the basis for local wall motion abnormalities commonly seen in patients with ischemic heart disease, computer-controlled isolated muscle studies were carried out. Methods: Force patterns of physiologically sequenced contractions (PSCs) from rat left ventricular muscle preparations under well-oxygenated conditions and during periods of hypoxia and reoxygenation were recorded and stored in a computer. Force patterns of hypoxic-reoxygenating and oxygenated myocardium were applied to oxygenated and hypoxic-reoxygenating myocardium, respectively. Results: Observed patterns of shortening and lengthening closely resemble those obtained from ischemic and non-ischemic myocardial segments using ultrasonic crystals in intact dog hearts during coronary occlusion and reperfusion, and are similar to findings reported in angiographic studies of humans with coronary artery disease. Conclusion: The current study, demonstrating motions of oxygenated isolated muscle preparations which are similar to those in perfused segments of intact hearts with regional ischemia, supports the concept that the multiple motions of both ischemic and non-ischemic segments seen in regional myocardial disease can be explained by interactions of strongly and weakly contracting muscle during the physiologic cardiac cycle.
High-Dose Statin Therapy in Patients With Stable Coronary Artery Disease
Authors: Johannes A.N. Dorresteijn, S. Matthijs Boekholdt, Yolanda van der Graaf, John J.P. Kastelein, John C. LaRosa, Terje R. Pedersen, David A. DeMicco, Paul M Ridker, Nancy R. Cook, Frank L.J. Visseren
Journal: Circulation (2013)

Clinicians need to identify coronary artery disease patients for whom the benefits of high-dose versus usual-dose statin therapy outweigh potential harm. We therefore aimed to develop and validate a model for prediction of the incremental treatment effect of high-dose statins for individual patients in terms of reduction of 5-year absolute risk for myocardial infarction, stroke, coronary death, or cardiac resuscitation.Based on data from the Treating to New Targets trial (TNT; n=10 001), a Cox proportional hazards model was developed comprising 13 easy-to-measure clinical predictors: age, sex, smoking, diabetes mellitus, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, history of myocardial infarction, coronary artery bypass grafting, congestive heart failure or abdominal aortic aneurysm, glomerular filtration rate, and treatment status (ie, atorvastatin 80 mg or 10 mg). External validation in the Incremental Decrease in End Points Through Aggressive Lipid Lowering trial (IDEAL; n=8888) confirmed adequate goodness-of-fit and calibration, but moderate discrimination (C-statistic, 0.63; 95% confidence interval, 0.62-0.65). Still, among participants of both trials combined, the model identified a group of 11.7% whose predicted 5-year number needed to treat was ≤25 and a group of 41.9% whose predicted needed to treat was ≥50. A decision curve shows that making treatment decisions on the basis of predictions using our model may improve net benefit.Estimation of the incremental treatment effect of high-dose versus usual-dose statin therapy in individual coronary artery disease patients enables selection of high-risk patients that benefit most from more aggressive therapy.http://www.clinicaltrials.gov. Unique identifiers: NCT00327691 and NCT00159835.
HOME MANAGEMENT OF THE DIET IN NEPHRITIS
Authors: J. P. O'HARE
Journal: JAMA (1923)

There are few fields in medicine in which the available facts are so little known and utilized by the practitioner as in nephritis. He continues to make the diagnosis of this disease by the finding of albuminuria. The patient's progress is measured by the amount of this albumin, and the treatment is prescribed in a similar way. There is, perhaps, a reasonable excuse for a lack of knowledge of tests of function and fine details of our modern knowledge. But there is absolutely no excuse for ignorance about those simple principles of pathologic physiology and elementary dietetics that are of immediate use to our patients. We all ought to know that in nephritis the body has more or less difficulty in handling water, salt and nitrogen. We know that if we give much water or salt these substances will be retained and the swelling increased in the edematous types of
Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease.
Authors: W C Reeves, D Cunningham, E J Schwiter, A Abt, S Skarlatos, M A Wood, L Whitesell
Journal: Circulation (1982)

The ability of methylprednisolone (MP) and ibuprofen (IB) to reduce the severity of the late state of radiation-induced heart disease was assessed in 57 New Zealand white rabbits. Before and shortly after cardiac irradiation, 15 rabbits received i.v. MP, 30 mg/kg twice daily for 3 days, and 15 others received IB, 12.5 mg/kg twice daily for 2 days. No drug was administered to 14 irradiated rabbits, and neither irradiation nor drugs were administered to 13 rabbits that served as controls, All 15 rabbits treated with MP and 13 of the 15 treated with IB lived for 100 days. Only seven of the untreated, irradiated rabbits lived that long. Longevity of each treated group of rabbits was better (p less than 0.01 and 0.05) than that of the untreated, irradiated rabbits. Surviving rabbits were killed 100 days after irradiation. Pericarditis (p less than 0.05) and pericardial effusion (p less than 0.01) were less frequent in the treated, irradiated groups than in the untreated, irradiated rabbits. At least some rabbits in each irradiated group had microscopic evidence of myocardial fibrosis. The fibrosis was quantitated by determination of myocardial hydroxyproline concentrations (MHP). MHP concentration in the untreated, irradiated rabbits was greater than in those treated with MP (p less than 0.05) or IB (p less than 0.01) and in the untreated, unirradiated rabbits (p less than 0.01). Early administration of MP or IB retarded the development of myocardial fibrosis, pericarditis and pericardial effusion, and improved survival in this experimental model of radiation-induced heart disease.
Abstract C29: Association of interferon-induced protein with tetratricopeptide repeats 1 gene family with human papilloma virus infection in patients with oral squamous cell carcinoma
Authors: Ai-Hsin Yen, Kuo-chu Lai, Ying-Chen Chen, Chung-Ji Liu, Kuo-Wei Chang, Te-Chang Lee
Journal: Cancer Research (2013)

Abstract Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) gene family is one of most responsive interferon-stimulated gene families. Four members have been characterized in humans, namely, IFIT1, IFIT2, IFIT3, and IFIT5. The encoded proteins mediate a variety of protein—protein interactions by tetratricopeptide repeat helix-turn-helix motifs to modulate on cellular functions, such as translation initiation, double-stranded RNA-induced signaling, cell proliferation and migration. We have previously demonstrated that IFIT2 silencing activates atypical PKC signaling and induces epithelial-mescenchymal transition (EMT), cell migration, invasion, and metastasis of oral squamous cell carcinoma (OSCC) cells in cultured or animal models. Our results also showed that IFIT2 is potentially a prognosis biomarker of patients with OSCC. In the present study, we further explore the roles of IFIT1 family proteins involved in the regulatory mechanism of metastasis in OSCC cells. We first confirmed that the proteins of various IFIT1 family members are significantly induced by interferon in a dose-dependent manner. We further characterized the expression of IFIT1, IFIT3, and IFIT5 proteins in patients with OSCC. Our present results revealed that most OSCC tumor tissues expressed a variety of amounts of IFIT2 proteins by immunohistochemical analysis. Although the expression levels of IFIT1 and IFIT3 were relatively lower than IFIT2, we observed a close association between IFIT1 and IFIT3 protein expression in OSCC patient-derived tumor specimens. Numerous studies have pointed out that human papillomavirus (HPV) infection is associated with a high risk of oral cancer. Among these 4 IFIT1 family members, we preliminarily demonstrated a well correlation between HPV E6 and IFIT5 protein expression in tumor specimens of OSCC patients, implying a critical role of IFIT5 in response of HPV infection. Accordingly, our present studies implicate that all IFIT1 family are activated by interferon but each member apparently participates in different cellular activities. Their roles involving in OSCC metastasis warrant our further investigation. Citation Format: Ai-Hsin Yen, Kuo-chu Lai, Ying-Chen Chen, Chung-Ji Liu, Kuo-Wei Chang, Te-Chang Lee. Association of interferon-induced protein with tetratricopeptide repeats 1 gene family with human papilloma virus infection in patients with oral squamous cell carcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr C29.
Lyme Disease — Success for Academia and the Community
Authors: Edward D. Harris
Journal: New England Journal of Medicine (1983)

Lyme disease belongs to the people. It was a concerned mother in 1975 who informed the state health department in Connecticut that 12 children in the village of Old Lyme (population 5000) had an illness that had been diagnosed as juvenile rheumatoid arthritis. Without her observations and those of another woman who reported to the Yale Rheumatology Clinic an "epidemic" of arthritis in her family, this fascinating affliction — which now perhaps has both a known cause and a cure — might have gone much longer without recognition.It is to the credit of members of the rheumatology group at . . .
574 ASSOCIATION OF GENETIC POLYMORPHISMS IN MITOCHONDRIAL ANTIOXIDANT SYSTEM WITH CIRRHOSIS AND HEPATOCELLULAR CARCINOMA IN HFE HEMOCHROMATOSIS
Authors: P. Nahon, A. Sutton, D. Pessayre, P. Rufat, N. Charnaux, J.-C. Trinchet, M. Beaugrand, Y. Deugnier
Journal: Journal of Hepatology (2010)
Acromegaly and Colon Cancer
Authors: ELOY A. ITUARTE
Journal: Annals of Internal Medicine (1984)

The occurrence of colon cancer in 1 patient with acromegaly prompted a study of an additional 12 patients with acromegaly. In addition to the index case, 1 patient was retrospectively discovered to have colon cancer, and 1 was found to have colonic adenocarcinoma in the course of the study. One patient had a presumptive sigmoid polyp shown by barium enema but refused further studies. Eight patients received colonoscopy. Two patients had adenomatous polyps and 1 had two hyperplastic polyps. This study supports previously published data on the occurrence of colon polyps in patients with acromegaly and suggests that the incidence of colon cancer is much higher than that expected by chance.
How Important Is Cognition for Women with Breast Cancer? Results of a Web-Based Study of 1071 Breast Cancer Patients Used To Augment Content Validity of the Breast Cancer Symptom Scale (BCSS) a New Health-Related Quality of Life Instrument.
Authors: I. Shapira, R. Gralla, B. Davis, J. Petersen, P. Hollen, J. Horigan, A. Belland, K. Burg, J. Carleton
Journal: Cancer Research (2009)

Abstract Background:Cognitive difficulties, such as loss of memory or ability to concentrate, have been associated with chemotherapy and other treatments for breast cancer. Causes for intellectual impairments have been proposed, including biological and psychological factors, however, strong evidence is lacking. Regardless of the cause, it is important for caregivers to appreciate, which cognitive impairments most concern their patients. As part of this survey, we sought the opinions of women with breast cancer to ascertain how these women rated the ability to concentrate among 21 major issues.Methods:We utilized the established patient base of the web-based NexCura information resource to survey registered patients with breast cancer. Demographic stratifications included disease stage, age, menopausal status, time since diagnosis, prior/current treatment with surgery, RT, chemotherapy, hormonal, targeted, and CAM approaches. 1071 women (median age 53, 65% stage I, 43% &amp;gt; 2 years since diagnosis) completed the anonymous web-conducted survey. Patients ranked the importance of 21 issues on a 5-point scale. Issues included general, physical, functional, psychosocial and summative items.Results:Of all 21 items, the 1071 women ranked the ability to concentrate as one of the four most important factors, as determined by those who rated it in the top category (very important, 65%) and the top 2 importance categories (97%). It followed only overall quality of life in the “very important” category, and was tied with maintaining independence and the ability to sleep in the sum of the top 2 importance categories. Analysis is being conducted to determine if ratings by breast cancer subsets (newly diagnosed, on treatment, NED, hormonal or non-hormonal treatment, metastatic disease, survivor-status) will differ compared with the whole group.Conclusions:Interference with concentration can affect nearly every aspect of functioning and quality of life, and can have an impact on quality decision making. Regardless of whether causes of cognitive impairment have supporting evidence, caregivers should be aware of the level of importance of concentration to patients with breast cancer and report symptoms related to executive function.Our results from one of the largest groups of breast cancer patients surveyed to date support the belief that women value the ability to concentrate most highly. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5049.