tbuckley/cabot-search huggingface dataset:
NEPHROTOXIC SERUM NEPHRITIS IN RATS
Authors: James H. Baxter, Howard C. Goodman
Journal: The Journal of Experimental Medicine (1956)

Studies have been carried out to determine the distribution of antigen capable of inducing the formation in rabbits of antibodies nephrotoxic for the rat. The results indicate that the antigen is present both in cortex and medulla of rat kidney. It can be extracted to a limited extent with saline. It is non-dialyzable and destroyed by boiling. The nephrotoxic serum antigen is also present in rat lung and placenta, in amounts roughly comparable to that in kidney, and in a number of other rat organs in smaller amounts. These various tissues not only are capable of stimulating the production of nephrotoxic antibodies, but each tissue is also able to absorb the nephrotoxic antibodies induced by injections of other rat tissues. These studies indicate that the nephrotoxic serum antigen in various rat tissues is the same or closely related. The nephrotoxic serum antigen of the rat is distinct from that of the dog and the rabbit, but there appears to be a cross-reaction between the nephrotoxic serum antigens of the rat and mouse. It is concluded that the nephrotoxic serum antigen is not a specific component of kidney; it is neither limited to kidney in its distribution within the rat, nor is the rat antigen present in kidney tissue of 2 other species examined. Rather, it is probable that the antigen is to a large extent specific for tissue of a given species. The preponderance of renal injury following injections of the anti-organ sera presumably is due to the occurrence in the kidney of large amounts of the antigen in positions of physiological importance in which it is exposed directly to the circulating antibodies.
Potomac Fever or White House Wisdom?
Authors: Joe H. Woody
Journal: JAMA (1990)

<h3>To the Editor.—</h3> If Dr Lee's statements truly reflect his views, I sincerely hope that he does not succeed in upgrading the position of President's physician from a "blue-collar" job to "one of the premier health-policy positions in the nation."<sup>1</sup> The cynicism with which Dr Lee views his fellow physicians is evident. His assertion that "as long as physicians are paid more to do more, they're going to find a way to do more tests and procedures and get paid more" is an insult to the vast majority of physicians who are ethical and honest and are trying to do what is best for their patients. He says that by rationing health care he means "cutting out the waste, some of which is motivated by physician greed." Greed may add to health care cost, but it is a minor factor. If Dr Lee has information that proves otherwise,
USE OF WHITMAN SPICA
Authors: Samuel Kleinberg
Journal: JAMA (1931)

<h3>To the Editor:</h3> —InThe Journal, January 10, Dr. Walter I. Galland describes a "modified Whitman spica" for the treatment of fracture of the neck of the femur. In his opening paragraph Dr. Galland makes several statements which are so completely at variance with my own experience, and, I am sure, with that of every one who knows<i>how</i>to apply a plaster-of-paris spica bandage, that I am compelled to correct the impression the doctor creates, namely, that undesirable results attend the use of the ordinary or, what Dr. Galland calls, a "full" spica. Dr. Galland says that the application of a full spica, extending from the ribs to the toes in an elderly patient, is an expedient often fraught with serious consequences. On account of the dorsal decubitus which the spica necessitates, plus the undue confinement of the costal cage, with consequent diminution of the respiratory excursion, the patient
Protein Topology of Presenilin 1
Authors: Andrew Doan, Gopal Thinakaran, David R Borchelt, Hilda H Slunt, Tamara Ratovitsky, Marcia Podlisny, Dennis J Selkoe, Mary Seeger, Samuel E Gandy, Donald L Price, Sangram S Sisodia
Journal: Neuron (1996)

Mutations in a gene encoding a multitransmembrane protein, termed presenilin 1 (PS1), are causative in the majority of early-onset cases of AD. To determine the topology of PS1, we utilized two strategies: first, we tested whether putative transmembranes are sufficient to export a protease-sensitive substrate across a lipid bilayer; and second, we examined the binding of antibodies to specific PS1 epitopes in cultured cells selectively permeabilized with the pore-forming toxin, streptolysin-O. We document that the "loop," N-terminal, and C-terminal domains of PS1 are oriented toward the cytoplasm.
Hospital chief resigns after phone tapping
Authors: S Kingman
Journal: BMJ (1994)

A consultant in an NHS trust hospital has taken early retirement after discovering that the trust's chief executive tapped his telephone. Dr John Spencer, consultant radiologist at Luton and Dunstable Hospital NHS Trust, has signed an agreement not to speak publicly about the circumstances surrounding his retirement.

The chief executive, Mrs Averil Dongworth, eventually resigned after consultants at the hospital passed a motion of no confidence in her. The vote was 46 for and one against.

Luton police have passed a file on the tapping to the Crown Prosecution Service. They are still waiting to hear the service's opinion on whether the Interception Communications Act 1985 was contravened in this case. If the police want to tap someone's phone, they have to seek the permission of the Home Secretary.

According to a detailed article in the Guardian on 1 April, Dr Spencer discovered an …
Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma
Authors: J.D. MOUNTZ, M.B.DOWNS MINOR, R. TURNER, M.B. THOMAS, F. RICHARDS, E. PISKO
Journal: British Journal of Dermatology (1983)

Rats injected with bleomycin over a 58-week period developed weight loss, alopecia, hyperpigmentation, skin thickening and skin tautness when compared with saline-injected control animals. The only significant abnormality in laboratory blood tests was an increased sedimentation rate in the bleomycin-treated rats compared with controls. Histological examination of dorsal skin showed atrophied sebaceous glands and increased collagen fibres, with diameters ranging from 37·5 to 75 nm as compared with 72·5 to 100 nm in control animals. Chronic bleomycin exposure produces clinical, histological and ultrastructural skin changes similar to those found in human progressive systemic sclerosis (scleroderma).
GLUCAGON-LIKE PEPTIDE-1 RECEPTOR ACTIVATION REDUCES COMPENSATORY HYPERTROPHY AND LEFT VENTRICULAR REMODELING IN A PORCINE MODEL OF ISCHEMIA AND REPERFUSION
Authors: Torsten Vahl, Carlos Santos-Gallego, Teresa Arias, Maria Lopez-Benito, Javier Sanz, Martin Goldman, Roger Hajjar, Valentin Fuster, Juan Badimon
Journal: Journal of the American College of Cardiology (2012)
Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration.
Authors: D L Granger, R R Taintor, J L Cook, J B Hibbs
Journal: Journal of Clinical Investigation (1980)

Cytotoxic activated macrophages (CM) inhibited the growth of neoplastic L1210 cells in vitro but L1210 cell death was minimal to nonexistent. L1210 cells injured by CM were separated from macrophages and studied in an isolated system. CM-injured L1210 cells had an absolute requirement for glucose or another glycolyzable hexose (mannose or fructose) for at least 40 h after removal from macrophages. If the culture medium lacked sufficient concentration of one of these sugars, CM-injured L1210 cells died within 4 h. Uninjured L1210 cells cultured alone or with peptone-stimulated macrophages had no such requirement and maintained complete viability in hexoseless medium. The hexose requirement of CM-injured L1210 cells could not be fulfilled by other naturally occurring monosaccharides, glucose or mannose derivatives, or substrates that can be oxidized by mitochondria. The concentration requirements for glucose, mannose, and fructose by CM-injured L1210 cells correlated with the concentrations required to support maximal glycolysis of these sugars by other murine ascites cells. A concentration of 2-deoxy-D-glucose which completely inhibited L1210 cell glycolysis also complete prevented the ability of glucose or mannose to maintain viability of CM-injured L1210 cells. Interaction with CM led to inhibition of L1210 cell mitochondrial oxidative phosphorylation. This was supported by the findings that: (a) CM-injured L1210 cells had no Pasteur effect; their rate of aerobic glycolysis was the same as the rate of anaerobic glycolysis of uninjured L1210 cells, (b) Endogenous respiration of CM-injured L1210 cells was 15% of normal. Maximal inhibition of uninjured L1210 cell respiration by a specific mitochondrial poison (oligomycin) was nearly the same (13% of normal). It followed that CM-injured L1210 cells required hexose for chemical energy production via the glycolytic pathway. CM-induced mitochondrial injury occurred in five other neoplastic cell lines tested.
Nodal Metastasis From Occult Thyroid Cancer Detected by FDG PET-CT in a Patient With 2 Known Malignancies
Authors: Yiyan Liu
Journal: Clinical Nuclear Medicine (2009)

It is well known that there is a considerable potential for a primary malignancy of the thyroid when focal uptake of the thyroid is identified incidentally on whole body FDG-PET CT imaging. However, incidental finding of only metastatic lesion from occult thyroid cancer by FDG-PET is not reported yet. We present a case of a patient with 2 known malignancies, who had a FDG PET-CT for evaluation of systemic disease of lymphoma as well as metastasis of prostate cancer. A FDG-avid cervical lymph node was identified incidentally without concurrent thyroid uptake. Excisional biopsy of the node suggested metastatic papillary carcinoma from the thyroid. Subsequent thyroidectomy confirmed a large tumor focus in the right lobe of the thyroid, which was not well visualized on either CT or ultrasound. When FDG-avid cervical lymphadenopathy is identified incidentally on PET-CT imaging, thyroid carcinoma may be considered in the differential diagnosis in some non-head/neck malignancy cases even though no coexisting abnormal uptake is noted in the thyroid.
Lymphocyte transformation in patients with cobalt dermatitis
Authors: NIELS K. VEIEN, ELSE SVEJGAARD
Journal: British Journal of Dermatology (1978)

A lymhocyte transformation test with cobalt chloride was performed in 14 patients who had positive cobalt patch tests and eczema compatible with a cobalt induced contact dermatitis and in 9 controls. Eight of the patients had strongly positive patch tests, while 6 had weakly positive patch tests. Patients and controls showed equivalent responses to the mitogens, phytohaemagglutinin, pokeweed mitogen, and concanavalin A, as well as to the recall antigens, purified protein derivative and Candida albicans. A 1:5000 dilution in RPMI-1640 medium of a 1% aqueous solution of cobalt chloride proved optimal in distinguishing patients from controls. With this dilution, a significantly higher lymphocyte transformation was found in patients with strongly positive cobalt patch tests than in the controls. No significant difference was detected when the results for patients with weakly positive patch tests were compared with those of the controls.
In Memoriam Jan Kristoffer Konarski (Svensson)
Authors: T. Theorell
Journal: Psychotherapy and Psychosomatics (2002)

Obituaries| February 11 2002 In Memoriam Jan Kristoffer Konarski (Svensson) Subject Area: Psychiatry and Psychology T. Theorell T. Theorell Stockholm, Sweden Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (2002) 71 (2): 64–65. https://doi.org/10.1159/000049347 Article history Published Online: February 11 2002 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation T. Theorell; In Memoriam Jan Kristoffer Konarski (Svensson). Psychother Psychosom 1 April 2002; 71 (2): 64–65. https://doi.org/10.1159/000049347 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 2002Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Optimal Sampling Sites for Repeat Prostate Biopsy: A Recursive Partitioning Analysis of Three-Dimensional 26-Core Systematic Biopsy
Authors: Satoru Kawakami, Tetsuo Okuno, Junji Yonese, Toru Igari, Gaku Arai, Yasuhisa Fujii, Yukio Kageyama, Iwao Fukui, Kazunori Kihara
Journal: European Urology (2006)
Interaction of Fat-stimulated Gastric Inhibitory Polypeptide on Pancreatic Alpha and Beta Cell Function
Authors: C. A. Verdonk, R. A. Rizza, R. L. Nelson, V. L. W. Go, J. E. Gerich, F. J. Service
Journal: Journal of Clinical Investigation (1980)

Gastric inhibitory polypeptide (GIP) is considered to be the principal mediator of the enteroinsular axis. A glucose-insulin clamp technique was used to study the effects of differing blood glucose levels on the insulinotropic and glucagonotropic actions of fat-stimulated GIP in seven healthy subjects, as well as the effect of physiologic hyperinsulinemia on GIP secretion. Blood glucose levels were clamped for 4 h at 43±2 mg/dl (hypoglycemic clamp), 88±1 mg/dl (euglycemic clamp), and 141±2 mg/dl (hyperglycemic clamp) in the presence of a constant insulin infusion (100 m U/kg per h).
Epidemiology and outcome of acute lung injury in European intensive care units
Authors: Christian Brun-Buisson, Cosetta Minelli, Guido Bertolini, Luca Brazzi, Jorge Pimentel, Klaus Lewandowski, Julian Bion, Jacques-André Romand, Jesús Villar, Adalbjörn Thorsteinsson, Pierre Damas, Apostolos Armaganidis, François Lemaire
Journal: Intensive Care Medicine (2004)
Any affiliation can lead to bias
Authors: T. L Boyce, B. Ward
Journal: BMJ (2008)

Lenzer and Brownlee rightly draw attention to the problem of undeclared commercial interests that conflict with the public interest and influence media reporting of medical advances, but there is a danger that their diagnosis and proposed solution ignore the underlying causes.1

Any affiliation, not just a link to a commercial enterprise, can lead to bias, and almost everybody has some sort of affiliation, …
TCT-727 Impact Of Coronary Artery Disease Severity Assessed by SYNTAX-Score On Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation
Authors: Giulio G. Stefanini, Stefan Stortecky, Davide Cao, Julie Rat-Wirtzler, Crochan J O'Sullivan, Lutz Buellesfeld, Ahmed Khattab, Fabian Nietlispach, Thomas Pilgrim, Christoph Huber, Thierry Carrel, Peter Jüni, Bernhard Meier, Peter Wenaweser, Stephan Windecker
Journal: Journal of the American College of Cardiology (2013)
A method for the long-term exposure of rabbits to environmental pollutant gases
Authors: GJ Douglas, JF Price, CP Page
Journal: European Respiratory Journal (1994)

The aims of the present study were twofold. Firstly, we wanted to develop a system for the exposure of rabbits to pollutant gases that would monitor gas concentrations accurately, allow flexibility, be simple to operate, and could be constructed at relatively modest cost. Additionally, we wanted to determine whether the procedures necessary for the daily exposure of young rabbits had any detrimental effect on their development. Using the environmental exposure system that we developed, littermate New Zealand White rabbits, neonatally immunized to either Alternaria tenuis or house dust mite antigen were exposed 2 h daily, from within 24 h of birth until 3 months of age, to either 4 ppm nitrogen dioxide (NO2), or 5 ppm sulphur dioxide (SO2) or ambient air. The environmental exposure system consists of four sections; a stainless steel exposure chamber; an airflow monitoring and control system and gas delivery system; a gas detector and monitoring system; and an exhaust fan. Equilibration and wash-out times of gas were short and the gas mixing within the chamber atmosphere was uniform. Levels of gases were reliably maintained throughout the period of exposure within predetermined limits. The weights of the immunized, gas-exposed animals did not differ significantly from those of the immunized, air-exposed animals at any time throughout the 3 month period of exposure. At 3 months of age, the basal values for lung resistance and dynamic compliance did not differ between gas- and air-exposed rabbits. These values did not differ significantly from those obtained from naive animals of the same age. Our results suggest that we have developed a sensitive, reliable and simple environmental exposure and monitoring system. It is anticipated that the methodology described will allow the careful investigation of the effects of long-term exposure to pollutant gases from birth on the development of airways hyperresponsiveness.
Agranulocytosis after Sulphapyridine
Authors: J. Dywien
Journal: BMJ (1941)

<h3>Abstract</h3> Selection on complex traits can rapidly drive evolution, especially in stressful environments. This polygenic selection does not leave intense sweep signatures on the genome, rather many loci experience small allele frequency shifts, resulting in large cumulative phenotypic changes. Directional selection and local adaptation are actively changing populations; but, identifying loci underlying polygenic or environmental selection has been difficult. We use genomic data on tens of thousands of cattle from three populations, distributed over time and landscapes, in linear mixed models with novel dependent variables to map signatures of selection on complex traits and local adaptation. We identify 207 genomic loci associated with an animal’s birth date, representing ongoing selection for monogenic and polygenic traits. Additionally, hundreds of additional loci are associated with continuous and discrete environments, providing evidence for local adaptation. These candidate loci highlight the nervous system’s possible role in local adaptation. While advanced technologies have increased the rate of directional selection in cattle, it has likely been at the expense of historically generated local adaptation, which is especially problematic in changing climates. When applied to large, diverse cattle datasets, these selection mapping methods provide an insight into how selection on complex traits continually shapes the genome. Further, by understanding the genomic loci implicated in adaptation, may help us breed more adapted and efficient cattle and begin understanding the basis for mammalian adaptation, especially in changing climates. These selection mapping approaches help clarify selective forces and loci in evolutionary, model, and agricultural contexts. <h3>Author Summary</h3> Interest in mapping the impacts of selection and local adaptation on the genome is increasing due to the novel stressors presented by climate change. Until now, approaches have largely focused on mapping “sweeps” on large-effect loci. Highly powered datasets that are both temporally and geographically distributed have not existed. Recently, large numbers of beef cattle have been genotyped across the United States, including influential individuals with cryopreserved semen. This has created multiple powerful datasets distributed over time and landscapes. Here, we map the recent effects of selection and local adaptation in three cattle populations. The results provide insight into the biology of mammalian adaptation and generate useful tools for selecting and breeding better-adapted cattle for a changing environment.
A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1–1q1
Authors: Susan Kass, Calum MacRae, Harry L. Graber, Elizabeth A. Sparks, Dennis McNamara, Harisios Boudoulas, Craig T. Basson, Peter B. Baker, Robert J. Cody, Mark C. Fishman, Nancy Cox, Augustine Kong, Charles F. Wooley, J.G. Seidman, Christine E. Seidman
Journal: Nature Genetics (1994)
Assessment of a new transtelephonic portable spirometer.
Authors: S Abboud, I Bruderman
Journal: Thorax (1996)

BACKGROUND: A new portable spirometer, the Spirophone, has been developed that records a subject9s blow and can then transmit all the data by telephone to a receiving centre for analysis and comment. Tests of this device were undertaken to determine its accuracy and reliability. METHODS: The performance of the Spirophone was tested using computer generated wave forms, by delivering blows from calibrated syringes at different flows, and by comparing subjects9 blows with those recorded with a commercial spirometer. RESULTS: Using computer generated wave forms all lung function indices were accurate to within 1% and blows delivered from calibrating syringes were accurate to within 5%. When subjects performed repeated forced vital capacity (FVC) manoeuvres there were no significant differences between lung function indices recorded with the Spirophone and with a commercial spirometer. With the Spirophone and commercial spirometer in series the FVC and forced expiratory volume in one second (FEV1) were within 5% of each other in nine out of 10 healthy subjects. CONCLUSION: The Spirophone recorded maximal forced expiratory manoeuvres with acceptable accuracy, reliability, and reproducibility, and this system offers the ability to monitor a patient9s lung function at a centre remote from the patient.