tbuckley/cabot-search huggingface dataset:
Relation of Cardiac Work to Survival in Cardiogenic Shock in Dogs
Authors: Ronald H. Dietzman
Journal: JAMA (1967)

In this study we have evaluated the effects of the pressure and volume components of myocardial work on survival in cardiogenic shock. Experimental cardiogenic shock was produced in dogs by a modification of a method first described by Agress.<sup>1</sup>Quantitative changes in blood pressure, cardiac output, peripheral resistance, and myocardial work were obtained in a group of control dogs before and after the production of shock. Similar hemodynamic measurements were obtained in groups of dogs receiving vasopressor, vasodilator, or volume expansion therapy. The survival rate in each group was compared to the control group and related to the pressure and volume components of myocardial work. <h3>Materials and Methods</h3> Mongrel dogs weighing between 10 and 20 kg were premedicated with intramuscular injections of morphine sulfate (1 mg/kg of body weight). The dogs were anesthetized with intravenous sodium thiamylal to the depression of the corneal reflex. An endotrachial airway was inserted
Associations between Selected Biomarkers and Prognosis in a Population-Based Pancreatic Cancer Tissue Microarray
Authors: Mikiko Takikita, Sean Altekruse, Charles F. Lynch, Mark T. Goodman, Brenda Y. Hernandez, Mark Green, Wendy Cozen, Myles Cockburn, Maria Sibug Saber, Marie Topor, Chris Zeruto, Behnoush Abedi-Ardekani, Marsha E. Reichman, Stephen M. Hewitt
Journal: Cancer Research (2009)

Pancreatic cancer is the fourth leading cause of cancer death in the United States. Prognostic biomarkers are lacking, and treatment has limited effect on survival. Tissues from Surveillance, Epidemiology, and End Results registries (Iowa, Hawaii, and Los Angeles) were used to build a tissue microarray of 161 pancreatic tumors (113 resections and 48 biopsies). Proportional hazard models adjusted for age, race, sex, stage, time-period of diagnosis, and treatment. Associations were examined between markers (MUC1, MUC2, MUC5AC, synaptophysin, chromogranin, neuron specific enolase, epidermal growth factor receptor, HER2, CD5, CD138, CK5/6, CK19, CK20, and p53) and survival time from diagnosis. After adjusting for covariates, borderline statistically significant associations were seen between expression of each of the three mucins (MUC1, MUC2, and MUC5AC) and shorter survival time. The associations strengthened for 154 (96%) adenocarcinomas, particularly the 120 (75%) well-differentiated to moderately differentiated ductal adenocarcinomas, a tumor type that occurred more often in the cohort among White cases than cases of other racial origin (P<0.01). For differentiated ductal adenocarcinomas, associations with shorter survival time were seen for expression of all three mucins combined versus other mucin expression patterns (adjusted hazard ratio, 1.8; 95% confidence interval, 1.2-2.6) and for MUC2(+) versus MUC2(-) expression (adjusted hazard ratio, 1.6; 95% confidence interval, 1.1-2.4). Mucin gene expression, particularly MUC2 expression, may have prognostic value for differentiated adenocarcinomas. Tumor histologies differed in this and Japanese cohorts. The tissue microarray is available to evaluate other biomarkers. Tissue-based surveillance can be used to monitor tumor histology in populations and facilitate applied research.
An Inflammatory Cascade Leading to Hyperresistinemia in Humans
Authors: Michael Lehrke, Muredach P Reilly, Segan C Millington, Nayyar Iqbal, Daniel J Rader, Mitchell A Lazar
Journal: PLoS Medicine (2004)

Obesity, the most common cause of insulin resistance, is increasingly recognized as a low-grade inflammatory state. Adipocyte-derived resistin is a circulating protein implicated in insulin resistance in rodents, but the role of human resistin is uncertain because it is produced largely by macrophages.The effect of endotoxin and cytokines on resistin gene and protein expression was studied in human primary blood monocytes differentiated into macrophages and in healthy human participants. Inflammatory endotoxin induced resistin in primary human macrophages via a cascade involving the secretion of inflammatory cytokines that circulate at increased levels in individuals with obesity. Induction of resistin was attenuated by drugs with dual insulin-sensitizing and anti-inflammatory properties that converge on NF-kappaB. In human study participants, experimental endotoxemia, which produces an insulin-resistant state, causes a dramatic rise in circulating resistin levels. Moreover, in patients with type 2 diabetes, serum resistin levels are correlated with levels of soluble tumor necrosis factor alpha receptor, an inflammatory marker linked to obesity, insulin resistance, and atherosclerosis.Inflammation is a hyperresistinemic state in humans, and cytokine induction of resistin may contribute to insulin resistance in endotoxemia, obesity, and other inflammatory states.
230. In Vivo Fluorescence Tracking System for Cardiac Stem Cell Therapy
Authors: Kozo Hoshino, Hung Q. Ly, Irina Pomerantseva, Yoshiaki Takewa, Ryuichi Yoneyama, Yoshiaki Kawase, Alec M. DeGrande, John V. Frangioni, Roger J. Hajjar
Journal: Molecular Therapy (2006)

Background: In recent years, animal studies and clinical trials have highlighted the regenerative potential of cardiac cellular therapy in the setting of both myocardial infarction and heart failure. Understanding the fate of stem/progenitor cells (SPCs) transplanted in the injured myocardium remains a pivotal issue in this field. In light of recent advances in molecular imaging, near_infrared (NIR) imaging represents a promising approach for cellular labeling and tracking of grafted SPCs. Therefore, we hypothesized that NIR labeling and in vivo tracking of SPCs is feasible and will allow to document their biological fate. Methods: Bone marrow derived meschenchymal stem cells (BMMSCs) were isolated from Yorkshire swines (n=3), and cultured for 2 weeks. Myocardial infarction was induced in all swines by 60_minute balloon occlusion of the left anterior descending artery. On day 3 post_infarction, allogenic BMMSCs (average, 20×106 cells): 1) underwent cellular labeling with the dye IR_786; 2) were reinjected in the infarct artery via intracoronary injection. Cellular labeling was assessed as follow: IR_786 labeled BMMSCs were tracked with a unique in vivo fluorescence/NIR imaging system under open chest condition. Results: BMMSCs were successfully labeled with IR_786 with near 100% efficiency. Over 90 % of BMMSCs were viable following IR_786 labeling. At baseline, the NIR signal_to_background ratio (SBR) was 1 in the infarct artery territory. Following cell injection, SBRs of the latter territory promptly increased by 3 to 5 fold (Figure 1). The SBRs remained sufficiently elevated to permit tracking of BMMSCs distributions even at the time of 60 min after the injection. These data will be discussed in conjunction with microscopic assessment of NIR labeled cells at the time of presentation. Conclusion: In vivo NIR imaging offers a new option to scrutinize reinjected cells. Cellular labeling of BMMSCs with IR786 is feasible; as well it allows both studying and appropriate tracking of the biological fate of transplanted SPCs in the setting of myocardial infarction.
QUANTITATIVE PHARMACOGENOMICS OF THE ANTICOAGULANT RESPONSE TO WARFARIN IN HEALTHY SUBJECTS
Authors: Sarina Van der Zee, Stuart Scott, Dana Doheny, Elizabeth Rothlauf, Inga Peter, Leah Blanchard, Daniella Kadian-Dodov, Steven Lubitz, Robert J.J. Desnick, Jonathan L. Halperin
Journal: Journal of the American College of Cardiology (2011)
Only half of GPs in study knew that advance directives could carry legal force in UK
Authors: K. Stewart, L. Bowker, S. Hayes, M. Gill
Journal: BMJ (1999)

EDITOR—Zaman and Battcock are right: doctors need to know more about advance directives.1 We hope that our paper will help them.2 Like Zaman and Battcock, we conducted a postal survey, surveying all 270general practitioners who refer patients to our hospitals in Hampshire and London; 214(79%) replied. …
TCT-808 Index of Microcirculation Resistance for Invasive Assessment of Coronary Microcirculation in a Porcine Model - Papaverine dose and Evolution in Time of Hyperemic Response
Authors: António Fiarresga, Eunice Oliveira, Mafalda Selas, Sandra Cavaco-Gonçalves, Duarte Cacela, Belmira Carrapiço, Ruiz C. Ferreira
Journal: Journal of the American College of Cardiology (2013)
Doctors' leaders and healthcare providers plan new code of conduct
Authors: S. Bagcchi
Journal: BMJ (2014)

Bodies representing doctors and hospitals in India have constituted a joint committee for formulating a new self regulatory code of conduct across the country.

The new code, which is being drawn up by the Indian Medical Association and the Association of Hospital Providers of India, could be ready before the end of the year. It has been reported that the code could “hold investors and members on the boards of medical establishments responsible” for unethical practices such as “giving cuts [kickbacks] to doctors and diagnostic facilities or …
Bacteremia Following Cardiac Catheterization
Authors: Martin D. Shickman, Lucien B. Guze, Morton L. Pearce, Joe Yamashita
Journal: New England Journal of Medicine (1959)

SEVERAL cases of fever after cardiac catheterization have recently been noted at this hospital. The characteristics of these episodes — namely, a shaking chill occurring approximately an hour after the onset of the operative procedure, followed by fever associated with hypotension — suggested bacterial contamination. No bacterial growth, however, was noted in any of several blood cultures obtained from each patient during these febrile episodes.During the years that cardiac catheterization had been performed at this hospital, no significant problem indicating inadequate sterilization had been described until these cases occurred. The catheters were sterilized by immersion in a solution of . . .
Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes.
Authors: M Cebrián, E Yagüe, M Rincón, M López-Botet, M O de Landázuri, F Sánchez-Madrid
Journal: The Journal of Experimental Medicine (1988)

In this report, we describe a novel activation antigen that appears very early after T cell activation and is absent in resting lymphocytes, through which agonistic proliferative signals can be triggered by mAb binding. It has been designated as activation inducer molecule (AIM) and is a disulphide-linked heterodimeric structure containing two polypeptide chains of Mr 33,000 and 27,000. The expression of AIM can be induced by different activation stimuli such as PMA, PHA, or anti-CD3 mAb, but not by the Ca2+ ionophore A23187, and it precedes the expression of other activation molecules such as 4F2 or the IL-2-R. Once AIM antigens are expressed on lymphocytes after stimulation with submitogenic doses of PMA, the binding of anti-AIM mAbs triggers a strong proliferative response. Furthermore, a comitogenic effect of the anti-AIM mAbs is exerted in the presence of either PHA or anti-CD3 mAb. The activation of lymphocytes through AIM antigens induces both IL-2 and IL-2-R receptor synthesis and is inhibited by anti-IL-2-R mAbs.
Interpreting Electrocardiograms: Using Basic Principles and Vector Concepts
Authors: Louis Lemberg
Journal: Annals of Internal Medicine (2002)

Medical Writings: Book Notes5 February 2002Interpreting Electrocardiograms: Using Basic Principles and Vector ConceptsLouis Lemberg, MDLouis Lemberg, MDDivision of Cardiology, University of Miami School of Medicine, Miami, FloridaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-3-200202050-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Hurst JW. 317 pages. New York: Marcel Dekker; 2001. $165.00. ISBN 0824705130. Order phone 212-696-9000.Field of medicine: Electrocardiography.Format: Hardcover book.Audience: Clinicians and house officers in internal medicine who intend to sharpen their diagnostic accuracy in electrocardiographic interpretation.Purpose: To provide and emphasize the vector concept as a basis for understanding electrocardiographic interpretation.Content: The book has 7 parts. Part I describes elements of the learning process. Some would consider this topic sophomoric; however, when J. Willis Hurst—an outstanding teacher, clinician, and prolific cardiovascular author—deems this chapter important, others should listen. The succeeding parts of the book discuss ... Author, Article, and Disclosure InformationAffiliations: Division of Cardiology, University of Miami School of Medicine, Miami, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 February 2002Volume 136, Issue 3Page: 260KeywordsArrhythmiaDiagnostic medicineElectrocardiographyHypocalcemiaInfarctionLeft ventricleMuscular dystrophiesMyocardiumRenal failureSoftware tools ePublished: 5 February 2002 Issue Published: 5 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Viral Infection-Homograft Interactions in a Murine Model
Authors: John D. Hamilton, James F. Fitzwilliam, K. S. Cheung, John Shelburne, David J. Lang, D. B. Amos
Journal: Journal of Clinical Investigation (1978)

The effects on some host defenses of murine cytomegalovirus (MCMV) and(or) EL(4), a mouse ascites homograft, were studied in mice. Assays of cellular and humoral immunity in response to either or both of these perturbations were carried out by quantitation of various immune activities.Limited studies demonstrated no effect of EL(4) inoculation on the host response to MCMV by organ viral titer, duration of viral persistence, or anti MCMV complement-fixing antibody titer. Prior infection with MCMV, however, resulted in greatly reduced numbers of splenocytes, the source in this study of immune effector cells. Residual splenocytes demonstrated less response to both phyto-hemagglutinin and lipopolysaccharide, particularly in the 2-3-wk interval after infection. Similarly, responder cells in mixed lymphocyte cultures were less reactive when derived from infected animals. Lymphocyte-mediated cytolysis of EL(4) was significantly less in mice infected on the day of and 7, 14, and 21 days before the tumor homograft with a return to control levels by 28 days. 90% of the cell-mediated cytolysis could be eliminated by treatment with anti-theta serum. Serum-mediated cytolysis of EL(4) was also reduced in infected animals. No suppressor cells or serum inhibitory factors could be identified in infected animals. Although alternative explanations exist, this study suggests that in infected animals there is a significant reduction in both the number and function of bone marrow-derived and thymus-derived cells directed against the alloantigens in EL(4).
Public Health Implications of Excessive Alcohol Consumption
Authors: Glen R. Hanson, Ting-Kai Li
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deficiency of Carnitine in Cachectic Cirrhotic Patients
Authors: Daniel Rudman, Charles W. Sewell, Joseph D. Ansley
Journal: Journal of Clinical Investigation (1977)

Carnitine is synthesized from lysine and methionine. In the rat, inadequate intake of either of these essential amino acids causes carnitine depletion. Inasmuch as protein deficiency is common in the hospital population, we have investigated the possible occurrence of nosocomial carnitine deficiency. Fasting serum carnitine concentration was measured in 16 normal and 247 patients in 16 disease groups. Normal range of carnitine was 55-103 μM. Only the cirrhotic group showed significant (P < 0.05) hypocarnitinemia. 14 of 36 hospitalized cirrhotics had subnormal values for serum carnitine. The creatinine/height index, midarm muscle circumference, and triceps skin-fold thickness indicated protein-calorie starvation in the 14 hypocarnitinemic liver patients. In six of the hypocarnitinemic cirrhotics (average serum level 50% of normal), spontaneous dietary intakes of carnitine, lysine, and methionine were measured and found to be only 5-15% as great as in six normocarnitinemic, healthy controls. When these six cirrhotic and six normal subjects were given the same lysine-rich, methionine-rich, and carnitine-free nutritional intake, the normals maintained normal serum carnitine levels and excreted 100 μmol/day, whereas the cirrhotics' serum level fell to 25% of normal, and urinary excretion declined to 15 μmol/day.
The Biochemists' Songbook
Authors: Nathaniel I. Berlin
Journal: JAMA (1982)

This is a brief book and contains the music and text of biochemical pathways written by Harold Baum at the University of London and dedicated to Sir Hans Krebs. Although this is not a textbook of biochemistry, in setting to music a number of biochemical pathways, and in illustrating those pathways in the customary fashion and linking these with words, Dr Baum has given us a different approach to studying the complexities of intermediary metabolism. The songs were prepared "for the department Christmas Party." A few are set to English tunes not well known in the United States, but most are familiar, such as "There is a Tavern in the Town," "Auld Lang Syne," and for the Australians, "Waltzing Matilda." "Battle Hymn of the Aerobes" is set to the tune of "Battle Hymn of the Republic": Mine eyes have seen the glory of respiratory chains In every mitochondrion, intrinsic to
Keratosis lichenoides chronica
Authors: K.S. RYATT, R. GREENWOOD, J.A. COTTERILL
Journal: British Journal of Dermatology (1982)

Journal Article Keratosis lichenoides chronica Get access K.S. RYATT, K.S. RYATT Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar R. GREENWOOD, R. GREENWOOD Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar J.A. COTTERILL J.A. COTTERILL Department of Dermatology, The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 2, 1 February 1982, Pages 223–225, https://doi.org/10.1111/j.1365-2133.1982.tb00933.x Published: 01 February 1982 Article history Accepted: 10 April 1981 Published: 01 February 1982
Demethylchlortetracycline in Clinical Practice
Authors: Joel L. Shapiro
Journal: JAMA (1961)

MORE THAN 4 years of laboratory investigations and clinical trials preceded the decision, arrived at a little more than a year ago, to make demethylchlortetracycline (Declomycin) available to physicians. The intensive preclinical experiments had shown that demethylchlortetracycline... was considerably more stable than its methyl analogues, resisting degradation at 100° C. both in highly acid and alkaline environments,<sup>1</sup>... was well absorbed from the gastrointestinal tract,<sup>2</sup>demonstrated a high degree of tissue penetration,<sup>3-5</sup>a longer half-life in the blood stream and a slower rate of renal clearance than the older analogues,<sup>6, 7</sup>in animals,... concentrations in the blood stream declined much more gradually and with less "peak" and "valley" fluctuations than the other tetracycline agents,<sup>2, 8</sup>... in vitro, was up to 3 times as potent as tetracycline against a large number of pathogens,<sup>9, 10</sup>... at various dosage levels, did not cause any alterations in hematologic,
Long‐term remission of blastic natural killer‐cell lymphoma after autologous peripheral blood stem‐cell transplantation
Authors: Masaki Yamaguchi, Mio Maekawa, Yoshihisa Nakamura, Mikio Ueda
Journal: American Journal of Hematology (2005)

Abstract We report here a case of blastic natural killer (NK)‐cell lymphoma treated successfully with autologous peripheral blood stem‐cell transplantation (APBSCT). A 57‐year‐old man had skin tumors and was diagnosed as having blastic NK‐cell lymphoma by tumor biopsy. Skin, lymph nodes, left tonsil, and bone marrow were involved at presentation. Chemotherapy led to complete remission (CR). To sustain CR, the patient underwent high‐dose chemotherapy in combination with 12 Gy of total‐body irradiation (TBI) followed by autologous peripheral blood stem‐cell rescue. He showed rapid recovery of hematopoiesis and could tolerate regimen‐related toxicity after APBSCT. He has maintained long‐term remission for 20 months after APBSCT. From this case, we concluded that APBSCT with preconditioning by TBI‐containing regimens might be a cure‐attaining treatment for disseminated blastic NK‐cell lymphoma and should be considered as a choice of treatment in cases where no suitable donors for allogeneic transplantation are available. Am. J. Hematol. 80:124–127, 2005. © 2005 Wiley‐Liss, Inc.
Endoscopic Clipping: A Useful Tool to Prevent Migration of Rectal Stents
Authors: S. Sebastian, M. Buckley
Journal: Endoscopy (2004)

Self-expanding metallic stents are commonly used in the treatment of patients with obstructing colonic tumors, either for palliation or as an alternative to defunctioning ileostomy prior to radiotherapy [1]. One of the common problems encountered after stent placement is migration of the stent, which can occur in up to 14 % of patients [2] [3]. Stent migration can occur either spontaneously or as a result of the shrinkage of the tumor following radiotherapy [4].
Trust was warned not to sign PFI deal that left it needing a bailout
Authors: Z. Kmietowicz
Journal: BMJ (2012)

An NHS hospital trust ignored warnings from the NHS regulator that a deal for a new hospital under the private finance initiative (PFI) was unaffordable and could leave it bankrupt, says an independent report into the events.1 

Monitor, the regulator of foundation trusts, had told Peterborough and Stamford NHS Foundation Trust (as well as the Department of Health and the Treasury) that its financial targets appeared unachievable, says the report from management consultants KPMG, which was commissioned by Monitor to analyse what lessons could be learnt from the events around the deal.

The trust had believed it could increase its earnings by more than 9.2% a year in …
Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia
Authors: Lewis B. Silverman, Jeffrey G. Supko, Kristen E. Stevenson, Christina Woodward, Lynda M. Vrooman, Donna S. Neuberg, Barbara L. Asselin, Uma H. Athale, Luis Clavell, Peter D. Cole, Kara M. Kelly, Caroline Laverdière, Bruno Michon, Marshall Schorin, Cindy L. Schwartz, Jane E. O'Brien, Harvey J. Cohen, Stephen E. Sallan
Journal: Blood (2009)