tbuckley/cabot-search huggingface dataset:
Sequential Treatment With Fluoxetine and Relapse-Prevention CBT to Improve Outcomes in Pediatric Depression
Authors: Betsy D. Kennard, Graham J. Emslie, Taryn L. Mayes, Paul A. Nakonezny, Jessica M. Jones, Aleksandra A. Foxwell, Jessica King
Journal: American Journal of Psychiatry (2014)

The authors evaluated a sequential treatment strategy of fluoxetine and relapse-prevention cognitive-behavioral therapy (CBT) to determine effects on remission and relapse in youths with major depressive disorder.Youths 8-17 years of age with major depression were treated openly with fluoxetine for 6 weeks. Those with an adequate response (defined as a reduction of 50% or more on the Children's Depression Rating Scale-Revised [CDRS-R]) were randomly assigned to receive continued medication management alone or continued medication management plus CBT for an additional 6 months. The CBT was modified to address residual symptoms and was supplemented by well-being therapy. Primary outcome measures were time to remission (with remission defined as a CDRS-R score of 28 or less) and rate of relapse (with relapse defined as either a CDRS-R score of 40 or more with a history of 2 weeks of symptom worsening, or clinical deterioration).Of the 200 participants enrolled in acute-phase treatment, 144 were assigned to continuation treatment with medication management alone (N=69) or medication management plus CBT (N=75). During the 30-week continuation treatment period, time to remission did not differ significantly between treatment groups (hazard ratio=1.26, 95% CI=0.87, 1.82). However, the medication management plus CBT group had a significantly lower risk of relapse than the medication management only group (hazard ratio=0.31, 95% CI=0.13, 0.75). The estimated probability of relapse by week 30 was lower with medication management plus CBT than with medication management only (9% compared with 26.5%).Continuation-phase relapse-prevention CBT was effective in reducing the risk of relapse but not in accelerating time to remission in children and adolescents with major depressive disorder.
Major mite allergen Der f 1 concentration is reduced in buildings with improved energy performance
Authors: F. Spertini, M. Berney, F. Foradini, C.‐A. Roulet
Journal: Allergy (2009)

Environmental conditions play a crucial role in mite growth, and optimal environmental control is key in the prevention of airway inflammation in chronic allergic rhinoconjunctivitis or asthma.To evaluate the relationship between building energy performance and indoor mite allergen concentration in a cross-sectional study.Major allergen concentration (Der f 1, Der p 1, mite group 2, Fel d 1 and Bla g 2) was determined by quantitative dot blot analysis from mattress and carpet dust samples in five buildings designed for low energy use (LEB) and in six control buildings (CB). Inhabitants had received 4 weeks prior to mite measurement a personal validated questionnaire related to the perceived state of health and comfort of living.Cumulative mite allergen concentration (with Der f 1 as the major contributor) was significantly lower in LEB as compared with CB both in mattresses and in carpets. In contrast, the two categories of buildings did not differ in Bla g 2 and Fel d 1 concentration, in the amount of dust and airborne mould collected. Whereas temperature was higher in LEB, relative humidity was significantly lower than in CB. Perceived overall comfort was better in LEB.Major mite allergen Der f 1 preferentially accumulates in buildings not specifically designed for low energy use, reaching levels at risk for sensitization. We hypothesize that controlled mechanical ventilation present in all audited LEB may favour lower air humidity and hence lower mite growth and allergen concentration, while preserving optimal perceived comfort.
Body Sensor Networks: In the Era of Big Data and Beyond
Authors: Carmen C. Y. Poon, Benny P. L. Lo, Mehmet Rasit Yuce, Akram Alomainy, Yang Hao
Journal: IEEE Reviews in Biomedical Engineering (2015)

Body sensor networks (BSN) have emerged as an active field of research to connect and operate sensors within, on or at close proximity to the human body. BSN have unique roles in health applications, particularly to support real-time decision making and therapeutic treatments. Nevertheless, challenges remain in designing BSN nodes with antennas that operate efficiently around, ingested or implanted inside the human body, as well as new methods to process the heterogeneous and growing amount of data on-node and in a distributed system for optimized performance and power consumption. As the battery operating time and sensor size are two important factors in determining the usability of BSN nodes, ultralow power transceivers, energy-aware network protocol, data compression, on-node processing, and energy-harvesting techniques are highly demanded to ultimately achieve a self-powered BSN.
FOUR BILIARY ANOMALIES: A PLEA FOR CHOLECYST-GASTROSTOMY
Authors: E. W. M. H. Phillips, D. Isaac, J. MacDonald
Journal: BMJ (1931)

The following four cases of biliary disorder seem not unworthy of record as curiosities, while each presents one or more features of clinical, therapeutic, pathological, or surgical interest.The first two, contemporaneous in the same nursing home, demonstrate extremes in gall-bladder dimensions.A Diminutive Gall-Bladder A farmer, formerly robust, was never well after phlegmonous tonsillitis in 1924.In August, 1929, he came into our care, gravely ill from pernicious anaemia, with advanced subacute combined degeneration of the cord.Vigorous treatment witl liver, comnbined with arsenite of iron and hydrochloric acid, soon rendered feasible and successful an operation under novocain infiltration for a large left incarcerated scrotal lhernia, and for a right hydrocele of generous proportions.The former was a menace, and both militated against his re- education in walking.A series of attacks of biliary colic began in May, 1930, of iricrqasina frequency and severity, until the situation became intolerable; and his importunity overcame our reluctance to accept the operative risk.On operating through a Kocher incision, under ether-assisted infiltration anaesthesia, we found the liver, reduced to half its bulk, tucked high under the dome of the diaphragm, to which it was intimately bounid by perihepatic adhesions defying mobilization.The gall-bladder, which was extricated with difficultiy from its fibro-fatty shroud, was about three centimetres long, and of the width of a rather meagre appendix.Its lumen was charged with black grit, and con- tamied one friable black pigment stone.The viscus was enucleated, and the cystic duct drained tlhrough a separate stab puncture.A complete and fairly rapid convalescence ensued, at first seriously interrupted by paralytic ileus, which fortunately proved tractable to anti-gas-gangrene serum.
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
Authors: Jia-Yi Li, Elisabet Englund, Janice L Holton, Denis Soulet, Peter Hagell, Andrew J Lees, Tammaryn Lashley, Niall P Quinn, Stig Rehncrona, Anders Björklund, Håkan Widner, Tamas Revesz, Olle Lindvall, Patrik Brundin
Journal: Nature Medicine (2008)
The Role of Nuclear Medicine in the Evaluation of Complex Regional Pain Syndrome Type I
Authors: Charles M Intenzo, Sung M Kim, David M Capuzzi
Journal: Clinical Nuclear Medicine (2005)

Chronic pain resulting from complex regional pain syndrome type I (CRPS I), formerly referred to as the reflex sympathetic dystrophy syndrome (RSDS), is a diagnostic challenge to the clinician. It involves multiple organ systems, namely peripheral as well as central nervous, vascular, soft tissue, and skeletal. It usually develops as a consequence of trauma, without nerve injury. Signs and symptoms vary depending on the time since the initiating event, and there is no confirmatory histopathologic diagnosis. This article summarizes the current consensus on the classification, pathophysiology, and diagnostic approaches, emphasizing the role of scintigraphy in the management of this multisystem disorder.
Factors associated with the development of asthma and allergic diseases among residents Singapore schoolchildren: Increased risk among Singapore-born compared to non-Singapore-born children
Authors: X.S. Wang, T.N. Tan, L.P.C. Shek, D.Y.T. Goh, B.W. Lee, F.T. Chew
Journal: Journal of Allergy and Clinical Immunology (2003)
Idiopathic restrictive cardiomyopathy.
Authors: R J Siegel, P K Shah, M C Fishbein
Journal: Circulation (1984)

This report details the clinical, hemodynamic, and morphologic data from four patients 59 to 77 years old (mean 66) with a primary restrictive cardiomyopathy. All patients had symptoms of congestive heart failure, jugular venous distention, and murmurs of mitral and tricuspid regurgitation. Four patients required pacemakers, three for the brady-tachy syndrome and one for complete heart block. Chest x-ray demonstrated cardiomegaly in all four patients and pulmonary congestion and/or pleural effusions in three. Echocardiographic examination documented left atrial enlargement in all patients, along with normal left ventricular internal dimensions. Global left ventricular systolic function was normal in all, and left and right ventricular filling pressures were elevated and similar in three. A dip and plateau pattern was present in the pressure tracings of two of three patients. Unlike previous reports of restrictive cardiomyopathy, in our four patients there was no specific morphologic cause noted at necropsy. Pathologic evaluation demonstrated biatrial dilatation in all patients, with thrombi present in the atrial appendages in three. Normal ventricular cavity size and mild right ventricular hypertrophy were present in all patients and mild-to-moderate left ventricular hypertrophy was present in two. There were no significant pericardial, endocardial, or valvular abnormalities and no infiltrative myocardial disorders were present. Light and electron microscopic studies demonstrated only interstitial fibrosis of the myocardium. A restrictive hemodynamic profile may be observed in the absence of specific infiltrative disorders and affected patients may exhibit a prolonged clinical course of 4 to 14 years (mean 9). However, in these patients congestive heart failure responded poorly to medical therapy or surgical correction of valvular regurgitation, which is common in this disorder.
Correction: Clinical Implications of Short-Term Variability in Liver Function Test Results
Authors: Mariana Lazo
Journal: Annals of Internal Medicine (2009)

Corrections7 April 2009Correction: Clinical Implications of Short-Term Variability in Liver Function Test ResultsFREEMariana Lazo, MD, ScMMariana Lazo, MD, ScMFrom Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-7-200904070-00017 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail On page 349 of our article (1), the second paragraph of the Measurements section says “ … we defined elevated liver test results as … alkaline phosphatase levels higher than 177 U/L … ” It should say “ … we defined elevated liver test results as … alkaline phosphatase levels higher than 117 U/L … ”. We verified that all results and analyses used correct values.Mariana Lazo, MD, ScMJohns Hopkins Bloomberg School of Public HealthBaltimore, MD 21205Reference1. Lazo M, Selvin E, Clark JM. Brief communication: clinical implications of short-term variability in liver function test results. Ann Intern Med. 2008;148:348-52. [PMID: 18316753] LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: From Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBrief Communication: Clinical Implications of Short-Term Variability in Liver Function Test Results Mariana Lazo , Elizabeth Selvin , and Jeanne M. Clark Metrics Cited byEvaluation of abnormal liver biochemical test results: Does the hare finally beat the tortoise? 7 April 2009Volume 150, Issue 7Page: 504KeywordsLiverLiver function testsPhosphatases ePublished: 7 April 2009 Issue Published: 7 April 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Transgastric Esophagoscopy with Antegrade Dilation
Authors: S. Leong, P. Kortan, R. Gray, N. Marcon, G. Haber
Journal: Endoscopy (1994)

An 80-year-old man in whom successful dilation of an obstructed esophagus via retrograde esophagoscopy was carried out is reported here. His nutrition had been previously sustained by a feeding gastrostomy tube inserted under radiologic guidance. This gastrostomy stoma was dilated to allow passage of a pediatric gastroscope into the stomach and esophagus. A guide wire was then negotiated past the esophageal stricture, under endoscopic vision and fluoroscopic guidance, into the oropharynx. Savary dilators were then passed over the guide wire perorally to dilate the stenosis. The patient was able to swallow liquids soon after the procedure. The use of Savary dilators over a guide wire introduced by retrograde esophagoscopy has not been previously described.
The switch from IgM to IgG secretion in single mitogen-stimulated B-cell clones.
Authors: J Andersson, A Coutinho, F Melchers
Journal: The Journal of Experimental Medicine (1978)

The frequency of mitogen-reactive B cells yielding an IgG plaque-forming cell (PFC) response has been determined in vitro by limiting dilution analysis under culture conditions which allow every growth-induced B cell to grow and mature into a clone of Ig-secreting cells. The frequencies of lipopolysaccharide (LPS)-and lipoprotein-reactive precursors for IgG-secreting cells in the spleen of 6--8 wk old C3H/Tif and of C57BL/67 mice were found to be between 1 in 30 and 1 in 40 B cells and, therefore, only one tenth of the frequencies of mitogen-reactive precursors of clones secreting IgM. All IgG-secreting cells developed by switching in clones which previously contained IgM-secreting cells. This was shown in two experiments where the total number of mitogen-reactive precursor yielding IgM-secreting cell clones was limited such that 82 or 90% of all responding cultures originated from one precursor. Thus, of 480 cultures in the first and 720 cultures in the second experiment, 86 and 98 cultures were found positive, yielding IgM-secreting cells at day 5. When the same cultures were assayed at day 7 for IgG-secreting cells 9 and 10 cultures were found positive. All 19 cultures with IgG-secreting cells previously had contained IgM-secreting cells. The probability that IgG-secreting cells and IgM-secreting cells would have arisen from independent precursors can be calculated using Fisher's exact test of independence. For the two experiments those probabilities are 3.4 X 10(-7) and 4.0 X 10(-9). Since we have previously shown that each cell in a mitogen-stimulated, growing B-cell clone divides, and that each dividing cell secretes Ig, we conclude from these experiments that the large majority--in our experiments all--of the IgG-secreting cells in mitogen-stimulated B-cell clones develop by switch from IgM-secreting cells. IgG-secreting cells develop either early or late during growth of a single IgM-secreting cell clone. The switch to IgG secretion, therefore, is not fixed in the time of clonal growth after mitogenic stimulation.
Isolated ductus arteriosus aneurysm in the fetus and infant: a multi-institutional experience
Authors: Umesh Dyamenahalli, Jeffrey F Smallhorn, Tal Geva, Jean-Claude Fouron, Patricia Cairns, Luc Jutras, Victoria Hughes, Marlene Rabinovitch, Catherine A.E Mason, Lisa K Hornberger
Journal: Journal of the American College of Cardiology (2000)
Apolipoprotein E and Neurocognitive Function—Reply
Authors: Mary Malloy, Bruce Miller, John Kane
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Treating Substance-Use Disorders Among Physicians
Authors: Roland E. Herrington
Journal: JAMA (1982)

Of 40 participants of a two-year program for rehabilitating alcohol- and other-drug-dependent physicians, 15 have completed 24 months of treatment and monitoring, eight have completed 12 to 23 months, ten have completed one to 11 months, and seven discontinued treatment before completion. Of the 33 treated physicians, 31 have returned to full practice and 22 have experienced no relapse. The prognosis is quite favorable for most impaired physicians in appropriate treatment, monitoring, and follow-up are provided.
Pesticide Urinary Metabolite Levels of Children in Eastern North Carolina Farmworker Households
Authors: Thomas A. Arcury, Joseph G. Grzywacz, Dana B. Barr, Janeth Tapia, Haiying Chen, Sara A. Quandt
Journal: Environmental Health Perspectives (2007)

In this investigation we documented the pesticide urinary metabolite levels of farmworker children in North Carolina, determined the number of different metabolites detected for each child, and delineated risk factors associated with the number of metabolites.
FDA Advisory Panel Recommends Approval of Drug for Preoperative Treatment of Breast Cancer
Authors: Jill Jin
Journal: JAMA (2013)

In a nearly unanimous vote, an advisory panel for the US Food and Drug Administration (FDA) voiced its support on September 12 for the approval of the drug pertuzumab for use in the neoadjuvant (preoperative) treatment of breast cancer.

Pertuzumab, a monoclonal antibody targeting the HER2/neu receptor, was approved by the FDA in 2012 for use in combination with trastuzumab and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer who had not received prior anti-HER2 therapy or chemotherapy. If the FDA takes its advisory panel�s advice, pertuzumab would also be approved for use as neoadjuvant treatment in early HER2-positive breast cancers.
Bucket Diagrams: A Problem Solving Approach to Renal Physiology
Authors: Francis Dumler
Journal: JAMA (1994)

This book is a pleasant surprise. It has a simple pleasing appearance, is of the right size and weight, and has print that is easy to read. The content is limited to glomerular filtration rate, renal blood flow, glucose excretion, urinary concentration, and water balance. The book does not address acid-base or electrolyte physiology. The areas it does cover are presented in an interesting problem-solving way with a variety of examples (the learn-by-doing approach). To learn the specifics of nephron function, the student calculates values for flow, concentration, and so forth for each site on a bucket diagram, in series of examples that vary parameters. The glomerular capillary filtration section covers the very basics and then dwells on the effects of a variety of factors. These include an altered capillary permeability (Kf), altered oncotic pressure, constriction or dilation of the afferent arteriole, and constriction or dilation of the efferent arteriole.
Randomized comparative study of hemaccel vs. albumin infusion after total paracentesis in cirrhotic patients with refractory ascites
Authors: Francesco Salerno, Salvatore Badalamenti, Elettra Lorenzano, Pamela Moser, Pierluigi Incerti
Journal: Hepatology (1991)

Fifty-four cirrhotic patients with refractory ascites were treated with one-session large-volume paracentesis and randomly assigned to two groups. The first group was infused with human albumin, and the second group was infused with hemaccel at doses with comparable oncotic power. The two groups were compared for incidence of complications, recurrence of massive ascites after hospital dismissal and survival rate. The incidence of complications traditionally related to paracentesis, the probability of requiring readmission to the hospital for ascites (p = 0.48) and the probability of survival after entry into the study (p = 0.85) were the same for the two groups. A multivariate analysis of 16 parameters, including treatment modality, identified absolute unresponsiveness to diuretics as the only independent predictor of mortality. These results indicate that hemaccel infusion may safely replace albumin infusion after total paracentesis for cirrhotic patients with refractory ascites.
Climate change and health: implications for research, monitoring, and policy
Authors: A. Haines, A. J McMichael
Journal: BMJ (1997)

The potential effects of climate change on human health are summarised in the previous article.1 These are wide ranging and pose considerable challenges to both researchers and policy makers.2 The complexity of these environmental processes and their impact on health necessitates a multidisciplinary approach.

In environmental health there is a close relation between epidemiological research and those monitoring activities which seek evidence of changes in the environmental or health status of populations. A distinction is usually made between monitoring and surveillance, the latter being the continuing standardised recording of the occurrence of disease. In the context of climate change and health, however, both monitoring and surveillance are needed to (a) identify important changes in disease incidence, health risk indicators, or health status; (b) determine whether these changes are likely to be the result of local, regional, or global environmental changes; (c) to help develop countermeasures and assess their effectiveness; and (d) to develop hypotheses about the potential health effects of climate change. Monitoring should also help in the detection of unexpected events.3

Since there is uncertainty about the profile and rate of future climate change it is necessary to estimate effects on health in relation to specified probable climate scenarios. This process differs in several important ways from the more familiar empirical procedure of quantitative risk assessment.4 The latter is usually conducted in relation to some existing index of environmental exposure for which there is prior empirical evidence of direct (usually toxicological) health risks across an exposure range which includes the index exposure.

The three main approaches to health risk assessment based on scenarios are extrapolation based on specific (historical) analogue situations for some aspects of climate change; formal integrated mathematical modelling; and generalised assessments drawing on expert judgment of the range of health consequences (physical, …
Medical Consumption and Costs during a One-Year Follow-up of Patients with LUTS Suggestive of BPH in Six European Countries: Report of the TRIUMPH Study
Authors: N.J.A. van Exel, M.A. Koopmanschap, J. McDonnell, C.R. Chapple, R. Berges, F.F.H. Rutten
Journal: European Urology (2005)