tbuckley/cabot-search huggingface dataset:
Monoclonal antibodies to recombinant Der f 2 and development of a two-site ELISA sensitive to major Der f 2 isoallergen in Korea
Authors: K.Y. Jeong, H.S. Jin, S.H. Oh, C.‐S. Hong, I.‐Y. Lee, H.‐I. Ree, T.‐S. Yong
Journal: Allergy (2002)

Der f 2 is a major sensitizing allergen in patients allergic to house dust mites worldwide. Isoforms of Der f 2 have been reported and are known to have different antigenicities. The aim of this study was to facilitate antigenic analysis and to develop an improved method for the detection of Der f 2 isoallergen, which is prevalent in Korea.A two-site ELISA was developed with monoclonal antibodies (mAbs) which were produced against recombinant Der f 2 (rDer f 2) and applied to assess Der f 2 in bedding samples.A major isoform of Der f 2, found in Korea, was found to have amino acid variations especially at position 100 from lysine to glutamic acid, which is known to reduce significantly the binding affinity of mAbs when used to assess group 2 allergens. The detection limit of the developed two-site ELISA was determined to be about 8 ng/ml with rDer f 2 and 1 microg/ml with Derntatophagoides farinae crude extract. The average amount of Der f 2 in dust obtained from bedding samples from 89 homes in Seoul was estimated to be 25.61+/-10.70 microg/g dust.Assays using mAbs for rDer f 2 could be useful for the assessment of environmental allergen exposure and mAbs could be used to further characterize the isoallergens of Der f 2.
The Effect of Prospective Payment on Medicare Expenditures
Authors: Louise B. Russell, Carrie Lynn Manning
Journal: New England Journal of Medicine (1989)

Medicare's prospective payment system was introduced in 1983 to slow the growth of expenditures for hospital care, which from the bulk of Medicare costs. Instead of reimbursing hospitals for the actual costs of patient care, the system pays them at fixed rates for each admission. In this study, we estimated the savings to Medicare from the use of prospective payment. We analyzed the expenditure projections published in 10 successive annual reports (1979 to 1988) by the trustees of the federal Hospital Insurance Trust Fund, which pays hospital bills for Medicare beneficiaries. To show the effect of prospective payment, these projections were adjusted to correct for the different assumptions about inflation and admissions made in each report. We also examined trends in expenditures from the Supplementary Medical Insurance Trust Fund, which pays for outpatient services, to see whether the savings in hospital expenses were offset by higher spending for out-of-hospital services. We found that prospective payment has reduced Medicare's hospital costs substantially. Expenditures from the Hospital Insurance Trust Fund for 1990 are expected to be +12 billion less in 1980 dollars, and +18 billion in 1990 dollars, than was expected shortly before prospective payment went into effect--the equivalent of a savings of approximately 20 percent. By contrast, the effect of prospective payment on the supplementary fund has not been great. We conclude that the prospective payment system is having a major impact on Medicare's hospital expenditures and that the savings is not offset by an increase in outpatient expenditures.
Renal Effects of Ibuprofen, Piroxicam, and Sulindac in Patients with Asymptomatic Renal Failure
Authors: Andrew Whelton
Journal: Annals of Internal Medicine (1990)

Study Objective: To evaluate the effects of three chemically distinct nonsteroidal anti-inflammatory drugs (NSAIDs) on renal function in patients with asymptomatic, mild but stable chronic renal failure. Design: Prospectively randomized, triple-crossover study with at least 1-month washout between each of three treatment periods. Setting: Inpatient and outpatient clinical research center of a university teaching hospital. Patients: Convenience sample of 12 women with serum creatinine levels between 130 and 270 µmol/L (1.5 and 3.0 mg/dL). Mean glomerular filtration rate ± standard error was 0.36 ± 0.03 mL/s · m2 (37 ± 3 mL/min · 1.73 m2); mean effective renal plasma flow was 1.6 ± 0.18 mL/s · m2 (166 ± 19 mL/min · 1.73 m2). Interventions: Patients received ibuprofen, 800 mg three times daily; piroxicam, 20 mg daily; and sulindac, 200 mg twice daily for 11 days. Treatment was discontinued if serum creatinine rose by 130 µmol/L (1.5 mg/dL) or serum potassium exceeded 6 mmol/L (6 mEq/L). Measurements and Main Results: Three patients met our criteria for stopping ibuprofen by day 8; however, all patients completed piroxicam and sulindac therapy. When the three patients in whom ibuprofen was withdrawn were rechallenged with ibuprofen, 400 mg three times daily, two again developed evidence of acute renal deterioration. All three regimens suppressed renal prostaglandin production. Conclusions: These findings indicate that a brief course of ibuprofen, a compound widely used on a nonprescription basis, may result in acute renal failure in patients with asymptomatic, mild chronic renal failure. Additional studies are needed to assess the risk of piroxicam and sulindac in patients with more pronounced renal impairment and in patients receiving longer courses of therapy, which, according to our data, may result in drug accumulation.
The Racial Disparity in Infant Mortality
Authors: Ezra C. Davidson, Teiichiro Fukushima
Journal: New England Journal of Medicine (1992)

From the standpoint of both science and social policy, it is important to focus on the more than twofold disparity in mortality between black and white infants in the United States. This disparity turns partly on the risk of low-birth-weight infants (those weighing less than 2500 g), especially very-low-birth-weight infants (weighing less than 1500 g). Since infant mortality is inversely proportional to birth weight, the higher frequency of low birth weight among blacks partially explains the difference in mortality.The study by Kempe et al. in this issue of the Journal 1 again makes these points and identifies some of the . . .
Factors Determining Physician Reporting of Adverse Drug Reactions
Authors: Jan Koch-Weser, Victor W. Sidel, Roger H. Sweet, Paula Kanarek, Ann E. Eaton
Journal: New England Journal of Medicine (1969)

KNOWLEDGE about adverse reactions to drug therapy has arisen largely from spontaneous reports by physicians who observed these events in their patients. Such communications have been directed to medical journals, drug manufacturers, hospital drug committees, medical associations and governmental supervisory agencies. In the United States both the American Medical Association1 , 2 and the Food and Drug Administration3 , 4 have in recent years requested reports of adverse drug reactions from physicians and hospitals. Reports from practicing physicians have been almost entirely responsible for calling attention to previously unappreciated adverse drug effects. Despite the increasing use of prospective monitored surveillance for adverse drug reactions . . .
The physician as fellow servant
Authors: A. R. Holder
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway
Authors: Beat C. Bornhauser, Laura Bonapace, Dan Lindholm, Rodrigo Martinez, Gunnar Cario, Martin Schrappe, Felix K. Niggli, Beat W. Schäfer, Jean-Pierre Bourquin
Journal: Blood (2007)
Purification of adult hepatic progenitor cells using green fluorescent protein (GFP)-transgenic mice and fluorescence-activated cell sorting
Authors: Takahisa Fujikawa, Tetsuro Hirose, Hideaki Fujii, Shoshiro Oe, Kentaro Yasuchika, Hisaya Azuma, Yoshio Yamaoka
Journal: Journal of Hepatology (2003)
Traitement des polypes de l'intestin grêle au cours d'une entéroscopie: étude de faisabilité et de concordance avec les résultats de l'entéroscopie par vidéocapsule (VCE) préalable
Authors: G Rahmi, E Samaha, C Savale, B Landi, J Edery, T Maniere, JM Canard, R Jian, C Cellier
Journal: Endoscopy (2010)

Introduction: Les nouvelles techniques d'entéroscopie avec ballonet ou spiralée permettent maintenant la résection endoscopique de polypes du grêle. Le but de notre étude était d'évaluer la faisabilité de la polypectomie et la corrélation entre les résultats de la vidéo-capsule endoscopique préalable (VCE) et ceux de l'EDB pour la taille, la localisation et le nombre de polypes.
Physician Practice Patterns Under Hospital Rate-Setting Programs
Authors: Stephen Zuckerman
Journal: JAMA (1984)

Earlier studies of hospital rate-setting programs have focused primarily on their ability to contain the growth in hospital utilization and expenditures. While most analysts recognize the central role physicians play in influencing health care utilization and expenditures, regulatory programs have been directed primarily at the hospital. At this time, it is unclear what impact, if any, these programs have had on physicians. Our study presents a preliminary analysis of this issue based on data from 1978 to 1982. When we compared average incomes, fees, and utilization of physician services in states with hospital rate regulations with those in states without such programs, we found significant differences. Average net incomes grew at a 1.9% slower annual rate in states with strict hospital regulatory programs. If hospital regulation is having some impact on physicians, both the physician and hospital sector should be considered when evaluating the ability of these programs to contain health care costs. (<i>JAMA</i>1984;252:2589-2592)
Where shall John go? Holland.
Authors: D J Hosking
Journal: BMJ (1976)

There are several options open to doctors wanting to work in Holland for a year or two. Although many of the Dutch speak English, language remains the main bar to clinical medicine; this is less of a disadvantage in such specialties as radiology, pathology, and anaesthetics, and vacancies are fairly frequently advertised in the BM7. The main opportunities lie in academic or industrial medicine. The choice of academic centre for the doctor who has funds from England will depend on individual interests and training requirements. Most Dutch medical research is funded centrally through Government agencies, though contributions do come from industry and charitable foundations. There is strong competition for research posts (which are regarded as an important phase of medical training) and the English doctor may find it difficult to obtain support from this source, although occasional vacancies are advertised in English journals. An alternative often practised by American university staff is an exchange, either concurrently or sequen tially over two years. The former may have advantages, as houses and cars can often be exchanged as well as jobs. This sometimes leads to disappointment but the proximity of Holland to Britain allows both parties to assess the desirability of an exchange before being irrevocably committed. Research depending heavily upon doctor-patient relationships suffers from the same disadvantages as clinical medicine. An American psychologist friend of mine found the small nuances of meaning difficult to convey and was disappointed with the clinical aspect of his visit. On the other hand, it is surprising how much a little newly learned Dutch, a patient's half-forgotten English, and much goodwill can achieve in terms of a simple clinical history. Areas of incomprehension can at least be defined and resolved with the help of an interpreter, and it should not be difficult for the visitor to function effectively in this way, given that most of his colleagues (as well as the laboratory technicians) will speak very good English. Several large British and American companies have quite sizable operations in Holland, mainly in petrochemicals. Most of these companies are based in the Hague or Rotterdam in the south of the country and advertise in medical journals. Schooling and housing are usually arranged by the company and such posts may have attractions for the doctor with a young family, particularly since several of the English schools are situated in this area.
Scavengers of free radical oxygen affect the generation of low molecular weight DNA in stimulated lymphocytes from patients with systemic lupus erythematosus
Authors: Paul J. Benke, Henrique Levcovitz, Jean Paupe, Elaine Tozman
Journal: Metabolism (1990)

Factors that potentially affect the generation of excess low molecular weight DNA (LMW-DNA) in cultured phytohemagglutinin (PHA)-stimulated lymphocytes of patients with systemic lupus erythematosus (SLE) were studied because this species of DNA is consistently found and this DNA may play a role in the pathogenesis of the disease. Superoxide dismutase (SOD; 0.05 mg/mL), a scavenger of free radical oxygen, decreased LMW-DNA formation in lymphocytes by 22%. Co-cultivation with cysteamine, a second scavenger of free radical oxygen and a sulfhydryl radioprotective agent, resulted in a 32% decrease in the generation of excess LMW-DNA at a concentration of 0.5 × 10−3 mol/L and largely prevented its formation at 1.0 × 10−3 mol/L. Other free radical scavengers (catalase, mannitol, vitamins C and E), cyclooxygenase inhibitors (ibuprofen and aspirin), a xanthine oxidase inhibitor (allopurinol), and an iron chelator (desferoxamine) did not affect excess LMW-DNA formation. Glutathione (1 × 10−3 mol/L) had no effect and cysteine was toxic. Because scavengers of free radicals might be useful in the therapy of lupus, a trial of cysteamine (30 to 60 mg/kg/d) was administered to six acutely ill patients with SLE. A therapeutic benefit was not demonstrated, and some patients had exacerbation of disease. Lymphocyte cell growth from control and lupus subjects was stimulated when cysteamine, 1 × 10−5 to 1 × 10−4 mol/L was added to the media, but inhibited at concentrations of 2 × 10−4 mol/L or greater. These studies suggest that the autooxidation and toxicity of high-dose cysteamine preclude its therapeutic use as a free radical scavenger.
Murat Emre: bringing it all back home
Authors: Ruth Williams
Journal: The Lancet Neurology (2010)

The young Murat Emre had a plan: to learn everything he could about the brain, to apply that knowledge clinically for the good of mankind, and to serve his country. Emre is founder and chair of the Behavioural Neurology and Movement Disorders Unit at Istanbul University, Turkey, and an internationally renowned leader in his field. It is safe to say his plan was a success.
Vascular Smooth Muscle and the Anisotropy of Dog Carotid Artery
Authors: PHILIP B. DOBRIN, JAMES M. DOYLE
Journal: Circulation Research (1970)

Segments of dog carotid artery were held at in-situ length and studied in vitro after excitation of the muscle with norepinephrine and after poisoning of the muscle with potassium cyanide. In-situ length corresponded to a longitudinal strain of .57±.02 relative to the unstretched length. The longitudinal elastic modulus was about 4.1x10 6 dyn/cm 2 at in-situ length and zero transmural pressure. This value was not altered by excitation of the vascular smooth muscle. The longitudinal stress due to traction decreased as the longitudinal stress due to transmural pressure increased, and it was suggested that this interaction underlies the relative constancy of vessel length in situ. The Poisson's ratio between the circumferential and longitudinal directions was about 0.3 and was found to decrease slightly with activation of the vascular muscle. The data for the longitudinal modulus and for Poisson's ratio were used to compute the circumferential elastic modulus. Activation of the muscle increased the circumferential elastic modulus when plotted as a function of circumferential strain. Comparison between the moduli in the two directions revealed that the arterial wall is not isotropic at physiological pressures because the circumferential elastic modulus is greater than the longitudinal modulus. Calculations indicated that assuming isotropy slightly underestimates the true circumferential modulus at small circumferential strains, and greatly overestimates the true circumferential modulus at large circumferential strains. Active smooth muscle has little direct effect on these estimations, but does alter the error by contracting the vessel to smaller strains.
ROLE OF PERCUTANEOUS LEFT VENTRICULAR ASSIST DEVICES IN UNSTABLE VENTRICULAR ARRHYTHMIA ABLATION
Authors: Madhu Reddy, Srijoy Mahapatra, Moussa Mansour, Thomas Jared Bunch, Vijay Swarup, Larry Chinitz, Luigi Di Biase, Hemant Boolani, Jayasree Pillarisetti, Namratha Reddy, Sudharani Bommana, Donita Atkins, Raghuveer Dendi, Andrea Natale, Dhanunjaya Lakkireddy
Journal: Journal of the American College of Cardiology (2012)
Reversed Intrapulmonary Right-to-Left Shunt After Banding of the Patent Ductus Venosus
Authors: Kazuyoshi Suga, Nobuhiko Ogasawara, Naofumi Matsunaga, Yoshitsugu Sugio, Ryouichi Shimizu
Journal: Clinical Nuclear Medicine (2003)

Diffuse pulmonary microvascular arteriovenous communication developed in an 8-year-old girl with a patent ductus venosus. Tc-99m macroaggregated albumin (MAA) pulmonary perfusion scintigraphy with total-body imaging demonstrated multiple lung perfusion deficits and abnormal tracer uptake in systemic organs with hepatic radioactivity greater than the kidneys, suggesting the presence of right-to-left shunt and abnormal hepatic hemodynamics. I-123 iodoamphetamine transrectal portal scintigraphy revealed a large portosystemic venous shunt. The follow-up Tc-99m MAA perfusion scans after banding of the patent ductus venosus revealed partial improvement of the perfusion deficits and right-to-left shunt, indicating the possible reversibility of this pulmonary shunt complication.
Psychosomatic Obstetrics and Gynecology
Authors: Ann B. Barnes
Journal: JAMA (1980)

<i>Psychosomatic Obstetrics and Gynecology</i>is a collection of papers and chapters written by authors of varied backgrounds expressly for this volume or for other purposes. There has been little editing of style or format and minimal interchapter referral. Some chapters do accurately reflect psychological issues encountered in the care of obstetrical and gynecological patients and will be of use to those dealing with such situations for the first time, the chapter on adolescent sexuality and abortion being the most outstanding in this respect. Jennifer Niebyl's chapter on gynecological complaints and treatment is factual and helpful but not well adapted to the adolescent section. A chapter on fetal monitoring raises interesting issues, but no resolution is offered, nor does the chapter convincingly outline the negative side of fetal monitoring, for which documentation is actually available. Chapters on elective gynecological surgery and breast cancers are circumscribed by reliance on the psychological literature.
TCT-175 Does Diabetes Mellitus Impact Long-Term Clinical Outcomes After Percutaneous Coronary Saphenous Vein Graft Interventions In The Drug-Eluting Stent Era?
Authors: lakshmana Pendyala, Salem Badr, Israel Barbash, Hironori Kitabata, Joshua P. Loh, Sa'ar Minha, Alfazir Omar, Hideaki Ota, Augusto Pichard, Lowell F. Satler, William O. Suddath, Rebecca Torguson, Ron Waksman
Journal: Journal of the American College of Cardiology (2013)
Thumb Reconstruction by Transfer of Big Toe
Authors: P. Clarkson, R. Furlong
Journal: BMJ (1949)

MALE SUBFERTILITYBJOuL in a case of oligozoospermia the presence of a few fully active seminiferous tubules with complete inactivity in the remainder indicates little prospect of improvement, whereas if most tubules are found to be active, but at a reduced rate, treatment is well worth trying.Only 128 biopsies have been performed at this laboratory to date, and if nothing has been achieved beyond the fact that 27 patients could confidently be advised to abandon treatment, I feel amply repaid by the considerable time and expense thus saved.The subjectof testicular histology and its correlation with semen findings and with the effects of treatment is likely to prove of the greatest importance.It is mentioned here only briefly, as material is being collected for a more detailed report.SummaryA survey is made of the semen findings in 3,182 male partners of subfertile marriages, 125 of whom produced pregnancies subsequently.A separate group of 15 selected normally fertile men is described.Cases are quoted illustrating the need for adequate investigation of the male and for standardization of seminological technique.
A difficult balance
Authors: F. Godlee
Journal: BMJ (2008)

My predecessor but one, Stephen Lock, chose to call the book he wrote towards the end of his 16 years as editor “A difficult balance.” It was a good choice. Getting the right balance in a general medical journal is an editor’s greatest challenge. The BMJ walks various tightropes—or, put more positively, attempts to bridge many divides: between primary and secondary care, clinical medicine and public health, health care and health policy, the UK and the rest of the world, online and print, magazine and journal. One good thing is that when the balance tips too far in …
A ROENTGEN STUDY OF ONE THOUSAND CHESTS, AT CAMP DEVENS, MASS.
Authors: E. L. DAVIS
Journal: JAMA (1918)

During the six months from Oct. 12, 1917, to April 19, 1918, more than 1,000 chests have been examined roentgenologically in the roentgen-ray laboratory at Camp Devens, Mass. The findings in these cases have proved interesting enough to warrant summarization, and it is my purpose in this paper to give an account of the study. Some phases of the roentgen interpretation of pulmonary disorders here presented are not new, and the material presented is merely corroborative. Some of the phases, however, are practically new, and the ideas expressed are based on material previously not available. Where generalities seem to have been drawn without sufficient substantiation, I hope to establish and extend these conclusions by further and more detailed study. The patients dealt with in this study are men between the ages of 21 and 30 — officers and enlisted men of the Army. A few rare cases of officers above