tbuckley/cabot-search huggingface dataset:
933 PERFORMANCE CHARACTERISTICS OF THE COBAS AMPLIPREP/COBAS TAQMAN HCV QUANTITATIVE TEST, V2.0 FOR HCV-RNA DETECTION AND QUANTIFICATION
Authors: J. Vermehren, S. Süsser, M. Schütten, C. Füller, D. Perner, S. Diepstraten-Pas, R. Molenkamp, P. Gohl, G. Colucci, H. Zitzer, C. Sarrazin
Journal: Journal of Hepatology (2012)
Toxic Epidermal Necrolysis–like Lesions as a Manifestation of Lupus Erythematosus—The Clinical Picture of Two Cases
Authors: Belén Rubio‐González, Lara Angulo‐Martínez, Francisco Vanaclocha‐Sebastián, Concepción Postigo‐Llorente, Rafael Llamas‐Martín
Journal: Arthritis & Rheumatology (2014)
WHO links long term pill use to cervical cancer
Authors: O. Dyer
Journal: BMJ (2002)

A study carried out by the World Health Organization has produced the first compelling evidence of a long suspected link between the contraceptive pill and cervical cancer. The research, carried out by the WHO's International Agency for Research on Cancer, found that prolonged use of the oral contraceptive pill increased the risk of cervical cancer up to fourfold, but only in women who carry the human papillomavirus (HPV).

The agency's Multicentric Cervical Cancer Study Group reviewed eight studies from Thailand, the Philippines, Morocco, Brazil, Peru, Paraguay, Colombia, and Spain. Their results are published in last week's Lancet (2002;359:1085-92). Women who had taken the pill for 5-9 years were nearly three times more likely than non-users to develop cervical …
Frontline chemoimmunotherapy with fludarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia
Authors: Sameer A. Parikh, Michael J. Keating, Susan O'Brien, Xuemei Wang, Alessandra Ferrajoli, Stefan Faderl, Jan Burger, Charles Koller, Zeev Estrov, Xavier Badoux, Susan Lerner, William G. Wierda
Journal: Blood (2011)
Withdraw approval for Tamiflu until NICE has full data
Authors: Fiona Godlee
Journal: BMJ (2012)

In an open letter sent this week to Professor Sir Michael Rawlins, chairman of the National Institute for Health and Clinical Excellence, <i>BMJ</i> editor Fiona Godlee calls on him to withdraw approval for oseltamivir until NICE has received and reviewed the full clinical trial data and those anonymised data are made available for independent scrutiny. The letter is the latest addition to the <i>BMJ</i>’s open data campaign, which aims to achieve appropriate and necessary independent scrutiny of data from clinical trials. Here we publish Fiona Godlee’s letter and Mike Rawlins’s response (<i>BMJ</i> 2012;345:e8420)
IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation
Authors: Julien J. Karrich, Loes C. M. Jachimowski, Maho Nagasawa, Angela Kamp, Melania Balzarolo, Monika C. Wolkers, Christel H. Uittenbogaart, S. Marieke van Ham, Bianca Blom
Journal: Blood (2013)
Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma
Authors: Leonard B. Bacharier, Theresa W. Guilbert, Robert S. Zeiger, Robert C. Strunk, Wayne J. Morgan, Robert F. Lemanske, Mark Moss, Stanley J. Szefler, Marzena Krawiec, Susan Boehmer, David Mauger, Lynn M. Taussig, Fernando D. Martinez
Journal: Journal of Allergy and Clinical Immunology (2009)
Protective effects of protein transduction domain-metallothionein fusion proteins against hypoxia- and oxidative stress-induced apoptosis in an ischemia/reperfusion rat model
Authors: Kwang Suk Lim, Min-Ji Cha, Jang Kyoung Kim, Eun Jeong Park, Ji-Won Chae, Taiyoun Rhim, Ki-Chul Hwang, Yong-Hee Kim
Journal: Journal of Controlled Release (2013)
Adult Immunizations 1994
Authors: Ronald J. Bloomfield
Journal: Annals of Internal Medicine (1995)

Letters15 March 1995Adult Immunizations 1994Ronald J. BloomfieldRonald J. BloomfieldSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-6-199503150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The editorial about adult immunization [1] did not mention international air travelers. These people are at high risk for influenza, and I think that they should be immunized with the influenza vaccine. Airplanes have poor air circulation (obviously the windows cannot be opened), and if someone has influenza and is coughing or sneezing, many persons will breath in those viral particles.The influenza vaccine is a safe and inexpensive vaccine. Persons who intend to travel outside the United States should receive the influenza vaccine when they visit their internist for a pretravel consultation. This vaccine will be ...REFERENCE1. Task Force on Adult Immunization. Adult Immunization 1994. Ann Intern Med. 1994; 121:540-1. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1995Volume 122, Issue 6Page: 478KeywordsCholeraCoughingFeversSneezingVaccines Issue Published: 15 March 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Emergency planners should not assume that people will panic
Authors: Claire Frauenfelder
Journal: BMJ (2006)

Planners of responses to emergencies should not assume that all crises result in mass panic, a conference in London was told last week. 

Speaking at the Health Protection Agency's conference looking at the outcomes of the bombings in London on 11 July 2005, Simon Wessely, of the Institute of Psychiatry, London, said that people reacted “with individual fear but without panic.” He described how immediately after the bombs went off victims remained orderly, acted purposefully, and experienced a sense of unity, “forming powerful social bonds.” 

He likened the behaviour to the resilience shown during the London blitz in the second world war, when 35 000 people were killed. However, he said that problems might arise when people face acts of terrorism, because, unlike during a conventional war, they “have no defined role to play.” 

He discussed a study of a representative sample of 1000 people selected from among the London public 11 to 13 days after …
Clinical Evaluation of 5-Methyl-3-Phenyl-4-Isoxazolyl Penicillin in Staphylococcal Infections
Authors: Alexander M. Rutenburg, Harold L. Greenberg, Sabin S. Levenson, Fritz B. Schweinburg
Journal: New England Journal of Medicine (1962)

5-METHYL-3-PHENYL-4-ISOXAZOLYL penicillin (MPI penicillin) is a new synthetic penicillin prepared by acylation of 6-aminopenicillanic acid with 5-methyl-3-phenyl-4-isoxazolecarboxylic acid. The claims for this drug include resistance to penicillinase, in vitro efficacy against staphylococci resistant to penicillin G, as well as various other gram-positive bacteria, and acid stability, which permits oral administration.1 2 3 The present report deals with the in vitro antimicrobial activity of MPI penicillin∥ in comparison to penicillin G and methicillin against 98 isolates of staphylococci from clinical sources, and its efficacy in the treatment of 50 patients with staphylococcal infections. This series includes 17 patients who had failed to respond . . .
Symptom relief and quality of life after stenting for malignant bile duct obstruction.
Authors: A B Ballinger, M McHugh, S M Catnach, E M Alstead, M L Clark
Journal: Gut (1994)

Palliative treatment is appropriate for most patients with cancer of the head of pancreas. Insertion of a biliary stent relieves jaundice and pruritus but it is not known if stenting affects other symptoms or changes the quality of life. Nineteen patients have completed a standard questionnaire to assess symptom relief and quality of life after stent insertion. After stenting there was complete relief of jaundice and pruritus. Furthermore, there was also considerable improvement in anorexia and indigestion. All patients had anorexia before stent insertion, this was moderate/severe in 13 (68.4%). Anorexia was significantly better (p &lt; 0.01) a week after stenting and this benefit was maintained at 12 weeks (p &lt; 0.01). Sixteen (84.2%) patients complained of indigestion before stenting, moderate/severe in 11 (57.9%). This was significantly better (p &lt; 0.01) a week after stenting with complete relief in six at eight weeks (p &lt; 0.01). Fifteen (78.9%) felt that their mood was good/very good before stent insertion and this was unchanged even at the 12 week assessment. A similar result was obtained for physical health and level of activity. In conclusion stent insertion not only relieves jaundice and pruritus in these patients but also improves other symptoms and quality of life. The considerable improvement in appetite after stenting was of particular benefit.
Effect of cytokines on mediator release from human dispersed lung mast cells
Authors: T. Takaishi, Y. Morita, K. Hirai, M. Yamaguchi, K. Ohta, E. Noda, T. Morita, K. Ito, T. Miyamoto
Journal: Allergy (1994)

To evaluate the contribution of human lung mast cells (HLMC) to allergic inflammation, we investigated whether or not cytokines, including stem‐cell factor (SCF), monocyte chemotactic and activating factor (MCAF), and RANTES, activate HLMC. SCF induced histamine release from dispersed HLMC in a dose‐dependent fashion ( P &lt;0.01). The release was 7.8 ± 1.0% at 500 ng/ml SCF ( n = 9). This response was also observed in chopped lung tissue. HLMC from which surface IgE molecules had been removed by treatment with lactic acid responded to SCF, while these cells lost their response to anti‐IgE. The process was relatively rapid and reached a maximum in 5 min. This response required extracellular calcium, and it was observed at 37°C, but not at 4°C or 20°. A brief preincubation (10 min) with lower concentrations of SCF, which were ineffective in releasing histamine, enhanced anti‐IgE‐induced histamine release ( P &lt;0.05), while its enhancing effect was lost by the longer preincubation (30 min). SCF did not prime basophils to enhance stimulated‐histamine release. Interleukin (IL)‐1α, IL‐1β, IL‐3, IL‐4, IL‐5, granulocyte/macrophage‐colony stimulating factor (GM‐CSF), MCAF, and RANTES neither induced histamine release nor enhanced the release stimulated by anti‐IgE after a 10‐ or 30‐min preincubation. The combination of IL‐3 and IL‐4 showed no effect on histamine release from HLMC. Leukotriene (LT)C 4 /D 4 /E 4 production by SCF was negligible, as compared with anti‐IgE‐induced LT production. SCF at 1.5 ng/ml augmented anti‐IgE‐induced LT generation significantly (536+ 117 pg/10 5 mast cells and 1569 ± 258 pg/10 5 mast cells; P &lt;0.01). These results provide further evidence that numerous aspects of the phenotype of mast cells and basophils are heterogeneous, including structure, relevant secretagogues, and pharmacologic control.
Robert Whytt, the Soul, and Medicine
Authors: Lester S. King
Journal: JAMA (1970)

When a physician today thinks of the word "soul" he probably thinks of theology. But formerly the soul belonged as well to physiology, and indeed represented a physiological concept of utmost importance. Of course, "soul" was a complex term and, in various doctrines, had various grades and subdivisions relating to various functions. The soul had to do with sensation and perception and voluntary action, with tonus, involuntary movements, "sympathy," stimulus and response, "irritability," reflex activity, and other physiological processes. Physicians who used "soul" to explain phenomena belonged to the vitalist camp, while other physicians who explained physiological phenomena in physical and chemical terms belonged to the mechanist school. Robert Whytt (1714-1766) was an important vitalist. Born in Edinburgh, he studied medicine at the university there and lived most of his life in that city. He was deeply interested in physiology, particularly of the nervous system. While he held to the
Amphetamine Poisoning
Authors: Donald E. Espelin, Alan K. Done
Journal: New England Journal of Medicine (1968)

Twenty-two children with acute poisoning due to amphetamines or pharmacologically related compounds responded dramatically to treatment with chlorpromazine, some of them after failing to respond to barbiturates. Excessive sedation occurred only in patients poisoned with an amphetamine-sedative combination, and could be avoided by the use of fractional doses. Chlorpromazine is recommended as an effective antagonist in amphetamine poisoning.
Indicator-based assessment of environmental hazards and health effects in the industrial cities of upper Silesia, Poland.
Authors: Eleonora Wcislo, Tadeusz Dutkiewicz, Jerzy Konczalik
Journal: Environmental Health Perspectives (2002)

Using an indicator-based approach, we assessed environmental hazards and related health effects in populations of industrial cities with more than 100,000 inhabitants in Upper Silesia, Poland, and analyzed the relationship between environment and health. We adopted the method developed by Dutkiewicz et al. for assessing large geographic areas. Based on routinely collected environmental and health data, two groups of indicators, environmental indicators (EIs) and health status indicators (HSIs), related to environmental contamination were selected. The EI and HSI values were normalized and aggregated into synthetic measures using Strahl's taxonometric method. The synthetic measures indicated the intensity of environmental hazards and health outcomes. We used a three-level index scale to compare and rank the cities under the study and, consequently, to facilitate decision making. Findings of the assessment identified cities where actions aimed at reducing environmental hazards and improving population health status should be established as priorities. These cities included Chorzów, Katowice, Sosnowiec, Bytom, and Zabrze. We found a high correlation between the synthetic measures of environmental indicators and the synthetic measure of health status indicators (r = 0.77), as well as a high level of consistency between environmental hazard indices and environmental-related health status indices (73%). This may indicate the existence of a causal relationship between the environmental contamination within industrial cities and the health status of their inhabitants.
Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model
Authors: Kathryn E. Hitchcock, Danielle N. Caudell, Jonathan T. Sutton, Melvin E. Klegerman, Deborah Vela, Gail J. Pyne-Geithman, Todd Abruzzo, Peppar E.P. Cyr, Yong-Jian Geng, David D. McPherson
Journal: Journal of Controlled Release (2010)
Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure
Authors: Daniel J. Gottlieb, Gayane Yenokyan, Anne B. Newman, George T. O'Connor, Naresh M. Punjabi, Stuart F. Quan, Susan Redline, Helaine E. Resnick, Elisa K. Tong, Marie Diener-West, Eyal Shahar
Journal: Circulation (2010)

Background— Clinic-based observational studies in men have reported that obstructive sleep apnea is associated with an increased incidence of coronary heart disease. The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women. Methods and Results— A total of 1927 men and 2495 women ≥40 years of age and free of coronary heart disease and heart failure at the time of baseline polysomnography were followed up for a median of 8.7 years in this prospective longitudinal epidemiological study. After adjustment for multiple risk factors, obstructive sleep apnea was a significant predictor of incident coronary heart disease (myocardial infarction, revascularization procedure, or coronary heart disease death) only in men ≤70 years of age (adjusted hazard ratio 1.10 [95% confidence interval 1.00 to 1.21] per 10-unit increase in apnea-hypopnea index [AHI]) but not in older men or in women of any age. Among men 40 to 70 years old, those with AHI ≥30 were 68% more likely to develop coronary heart disease than those with AHI &lt;5. Obstructive sleep apnea predicted incident heart failure in men but not in women (adjusted hazard ratio 1.13 [95% confidence interval 1.02 to 1.26] per 10-unit increase in AHI). Men with AHI ≥30 were 58% more likely to develop heart failure than those with AHI &lt;5. Conclusions— Obstructive sleep apnea is associated with an increased risk of incident heart failure in community-dwelling middle-aged and older men; its association with incident coronary heart disease in this sample is equivocal.
Should Regionalization Only Be in 1 Direction?
Authors: Michael E. Zenilman
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Coccidioidal Granuloma in California
Authors: H. A. L. Ryfkogel
Journal: JAMA (1913)

<h3>To the Editor</h3> —InThe Journal(Dec. 21, 1912, p. 2253) there is reported by F. H. Bowles of Oakland, Cal., a case of coccidioidal granuloma, the nineteenth in California. Dr. Bowles has evidently overlooked a case I reported inThe Journal, Nov. 12, 1910, p. 1730. This case, which occurred in 1907, should therefore be the nineteenth case reported. There have been several cases in California, however, since the so called eighteenth case, which have not been reported as yet; Dr. Dixon of Stanford University has seen three cases.
Adult liver transplantation: what non-specialists need to know
Authors: G M Hirschfield, P Gibbs, W J H Griffiths
Journal: BMJ (2009)

#### Summary points Potential transplant recipients often outnumber donors Improved donor schemes, broader donor criteria, split liver grafts, and live donors (who donate a portion of their liver) can increase the number of transplants Long term survival after transplant is excellent Family doctors are important in the management and monitoring of hypertension, diabetes, hyperlipidaemia, and renal function, and in cancer surveillance after the transplant The prevention of end stage liver disease and the early detection of liver complications could reduce the number of transplants needed #### Sources and selection criteria There have been few large-scale randomised controlled trials and Cochrane reviews on liver transplantation; data mostly come from extensive registry descriptions, multiple case-series, or small trials. We have combined our knowledge with that published in recent guidelines and in articles identified by Pubmed searches with the term liver transplantation. The UK has approximately 6 000 surviving liver transplant recipients,1 and annually about 600 people with liver disease receive new livers. The post-transplant population is growing, since nearly 550 of those 600 patients are alive one year after the operation, and at least 300 are alive 20 years after.2 3 We review liver transplantation for a non-specialist audience, with an emphasis on transplants in adults. Common triggers for referral in people with chronic, usually cirrhotic, liver disease are progressive jaundice, diuretic-resistant ascites, or hepatocellular carcinoma (box 1). Early referral is recommended since patients vary in their disease progression, and the assessment must be thorough. Liver transplantation is principally aimed at restoring health and improving survival, but, unlike other operations with similar potential benefit, limited resources restrict the number of people who receive transplants. #### Box 1 Underlying indications that can lead to transplantation ##### Liver failure ###### Acute/subacute (approximately 10% of transplants)
Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology
Authors: Lonneke A.M. Gravendeel, Mathilde C.M. Kouwenhoven, Olivier Gevaert, Johan J. de Rooi, Andrew P. Stubbs, J. Elza Duijm, Anneleen Daemen, Fonnet E. Bleeker, Linda B.C. Bralten, Nanne K. Kloosterhof, Bart De Moor, Paul H.C. Eilers, Peter J. van der Spek, Johan M. Kros, Peter A.E. Sillevis Smitt, Martin J. van den Bent, Pim J. French
Journal: Cancer Research (2009)

Gliomas are the most common primary brain tumors with heterogeneous morphology and variable prognosis. Treatment decisions in patients rely mainly on histologic classification and clinical parameters. However, differences between histologic subclasses and grades are subtle, and classifying gliomas is subject to a large interobserver variability. To improve current classification standards, we have performed gene expression profiling on a large cohort of glioma samples of all histologic subtypes and grades. We identified seven distinct molecular subgroups that correlate with survival. These include two favorable prognostic subgroups (median survival, >4.7 years), two with intermediate prognosis (median survival, 1-4 years), two with poor prognosis (median survival, <1 year), and one control group. The intrinsic molecular subtypes of glioma are different from histologic subgroups and correlate better to patient survival. The prognostic value of molecular subgroups was validated on five independent sample cohorts (The Cancer Genome Atlas, Repository for Molecular Brain Neoplasia Data, GSE12907, GSE4271, and Li and colleagues). The power of intrinsic subtyping is shown by its ability to identify a subset of prognostically favorable tumors within an external data set that contains only histologically confirmed glioblastomas (GBM). Specific genetic changes (epidermal growth factor receptor amplification, IDH1 mutation, and 1p/19q loss of heterozygosity) segregate in distinct molecular subgroups. We identified a subgroup with molecular features associated with secondary GBM, suggesting that different genetic changes drive gene expression profiles. Finally, we assessed response to treatment in molecular subgroups. Our data provide compelling evidence that expression profiling is a more accurate and objective method to classify gliomas than histologic classification. Molecular classification therefore may aid diagnosis and can guide clinical decision making.
Apparent Intrauterine Fetal Withdrawal From Clomipramine Hydrochloride
Authors: Ruben Bromiker
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Clomipramine hydrochloride, a tricyclic antidepressant, is often used for the treatment of depressive disorders. In pregnant women, however, its safety has not been fully established. The drug may cause signs of toxicity or drug withdrawal in newborn offspring. In the latter event, jitteriness and seizures appear to be the most frequent manifestations.<sup>1-3</sup>The signs of withdrawal usually do not appear at birth because time is required for excretion of the drug and the subsequent onset of symptoms. We report an unusual case of a newborn who was symptomatic immediately after birth. A 33-year-old woman in her sixth pregnancy had an obsessive-compulsive disorder treated with clomipramine hydrochloride, 100 to 150 mg/d, from the 12th gestational week. At 32 weeks, she decided of her own accord to abruptly discontinue the drug. Four days later, she presented with premature contractions and imminent delivery. A 2.7-kg male was born by