tbuckley/cabot-search huggingface dataset:
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations
Authors: A. M. Dorrance, S. Liu, W. Yuan, B. Becknell, K. J. Arnoczky, M. Guimond, M. P. Strout, L. Feng, T. Nakamura, L. Yu, L. J. Rush, M. Weinstein, G. Leone, L. Wu, A. Ferketich, S. P. Whitman, G. Marcucci, M. A. Caligiuri
Journal: Journal of Clinical Investigation (2006)

We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1, HRX, and HTRX1), consisting of an in-frame partial tandem duplication (PTD) of exons 5 through 11 in the absence of a partner gene, occurring in approximately 4%-7% of patients with acute myeloid leukemia (AML) and normal cytogenetics, and associated with a poor prognosis. The mechanism by which the MLL PTD contributes to aberrant hematopoiesis and/or leukemia is unknown. To examine this, we generated a mouse knockin model in which exons 5 through 11 of the murine Mll gene were targeted to intron 4 of the endogenous Mll locus. Mll(PTD/WT) mice exhibit an alteration in the boundaries of normal homeobox (Hox) gene expression during embryogenesis, resulting in axial skeletal defects and increased numbers of hematopoietic progenitor cells. Mll(PTD/WT) mice overexpress Hoxa7, Hoxa9, and Hoxa10 in spleen, BM, and blood. An increase in histone H3/H4 acetylation and histone H3 lysine 4 (Lys4) methylation within the Hoxa7 and Hoxa9 promoters provides an epigenetic mechanism by which this overexpression occurs in vivo and an etiologic role for MLL PTD gain of function in the genesis of AML.
Late onset constrictive pericarditis after thoracic radiotherapy.
Authors: D L Scott, R D Thomas
Journal: BMJ (1978)

during exertion.There was also some blurring of vision in the right eye.Clinically he was normotensive.The right superficial temporal vessels were dilated and tortuous, and there was a prominent pulsation about 5 cm above his ear.A thrill was easily palpable, and a continuous bruit with systolic accentuation was heard.Ophthalmic examination showed nothing abnormal.At operation the arteriovenous fistula was approached by reflecting a temporal flap, as in the standard burr-hole procedure.The fistula was localised in the middle of the reflected flap, and a non-crushing intestinal clamp across the base of the flap provided complete haemostasis (see fig). 4.A .
Objective Visual Field Testing
Authors: Richard M. Copenhaver
Journal: JAMA (1963)

THE VALUE OF visual field testing is well established in the fields of ophthalmology, neurology, neurosurgery, and internal medicine. The time-consuming nature of this subjective test, with its inherent inaccuracies in patients unable to cooperate fully, is familiar to most clinicians. It was the purpose of this study to investigate the feasibility of objective visual field testing by use of a specially-designed digital computer to sum and extract from "noise" the small evoked occipital potentials produced in response to focal visual illumination. Previously, photic driving and the recording of evoked occipital potentials from gross (large area) ocular stimuli have sometimes been useful in indicating the side of a cerebral lesion.<sup>1-4</sup>In this investigation small stimuli were used in an attempt to achieve greater resolution, enabling the detection of visual field defects. "Blindspot experiments" were performed on normal subjects to determine the stimulus parameters and background illumination necessary to
Hepatitis C Is Focus of NIH Consensus Panel
Authors: Charles Marwick
Journal: JAMA (1997)

CONSENSUS conferences held by the National Institutes of Health (NIH) have almost always dealt with ways of managing a current clinical problem. In contrast, the most recent consensus meeting tried to deal with a future possibility: the emergence in the next few decades of an epidemic of hepatitis C. Nearly 4 million people in the United States are currently infected with hepatitis C virus (HCV). About 30000 new infections are diagnosed each year, and 8000 infected people die. "Without effective intervention, [those numbers are] expected to triple in the next 10 to 20 years," warned the consensus panel. Complications of HCV infection are now the major reason for liver transplantation in the United States. In the absence of any definitive treatment or preventive measure such as a vaccine, the panelists were charged, among other things, with recommending measures that physicians can take to slow the development of cirrhosis and ultimate
Do Leeches Die When Applied to the Skin in Cases of Poisoning by Oxalic Acid?
Authors: H. Hanks
Journal: BMJ (1860)

indicate its presence when the heart's action is much increased by mental or bodily exeertion; or, again, it may be so extensive as to render prolonged existence impossible.Then, also, de- fective states of the auriculo-ventricular valves are of more serious importance-more immediately prejudicial to life- than such states of the semilunar valves.Defective circulation, for instance, resulting from diseased aortic valves, may be compensated for by hypertrophy of the left ventricle; and, under such circumstances, so long at least as the mitral valves remain sound, life may be preserved.But when the mitral valves are seriously defective, then congestions, etc., of the lungs, which are its most immediate and necessary conse- quence, arise, and so render life very precarious.What are usually known as symptoms of heart disease, are in reality symptoms of the general disorders which result from the obstruction of the circulation here spoken of.These disorders, indeed, often indicate to us, by their severity, the importance of the valvular disease much more than the aus- cultating signs do.They are manifested in the heart itself, in the lungs, the brain, the abdominal organs, and genierally in the different parts and organs of the body.* I need hardly remind the student, that cardiac dropsies are of a me- chanical kind.The position of the fluid varies with the positioni of the body.Dropsy resulting froin renial disease, as is well ]known, usuially shows itself in the first instance in the face and upper parts on the body; on the other hand, the dropsy of the heart-disease invariably exhibits its presence first of all in the lower parts of the body.
IMPROVEMENT IN ANESTHETIC TECHNIC FOR DENTAL SURGERY
Authors: MORRIS ECKER
Journal: JAMA (1925)

In a previous article I 1 briefly outlined the evolution of anesthesia for dental purposes, gave the technic for synergistic anesthesia as developed in the course of extensive clinical experience and laboratory investigation, and made a comparison of 55,000 straight nitrous oxid-oxygen anesthesias with 5,000 synergistic anesthesias.  In an experience with 14,300 anesthesias in which synergistic methods were employed, cyanosis, jactitation, holding straps, and all elements of uncertainty were definitely eliminated, and the physical and nervous strain to which the operator employing the older methods was subjected was entirely obviated. Larger amounts of oxygen could be used, and the margin of safety was greatly increased.  Despite these satisfactory results and the apparent perfection of our anesthetic technic, the introduction of ethylene, in 1923, with the favorable reports of the laboratory and clinical findings, warranted us in trying out a number of cases with this agent for purposes of comparison with
Inhibition of Hypoxic Pulmonary Vasoconstriction by Nifedipine
Authors: Gérald Simonneau, Pierre Escourrou, Pierre Duroux, Alain Lockhart
Journal: New England Journal of Medicine (1981)

SEVERE pulmonary hypertension mainly due to hypoxic vasoconstriction may develop in patients with chronic airflow obstruction and acute respiratory failure.1 Experiments in isolated rat lungs have implied that the calcium antagonist verapamil inhibits hypoxic pulmonary vasoconstriction.2 A preliminary report on patients with hypoxia suggests that verapamil causes an immediate drop in pulmonary vascular resistance.3 However, the concomitant fall in cardiac output may be hazardous in these severely hypoxic subjects. Nifedipine, a new calcium antagonist, causes few side effects4 and is a powerful vasodilating agent of systemic vessels5; as a result it usually increases cardiac output in both normal subjects . . .
RETRACTED: Reply from Authors re: Declan G. Murphy, Anthony J. Costello. How Can the Autonomic Nervous System Contribute to Urinary Continence Following Radical Prostatectomy? A “Boson-like” Conundrum. Eur Urol 2013;63:445–7
Authors: Ashutosh Tewari, Wesley Ludwig, Atsushi Takenaka, Abhishek Srivastava, Sameer Chopra, Anthony Pham, Prasanna Sooriakumaran, Matthieu Durand, Bilal Chughtai, Siobhan Gruschow, Alexandra Peyser, Niyati Harneja, Robert Leung, Richard Lee, Michael Herman, Brian Robinson, Maria Shevchuk
Journal: European Urology (2012)
Polymicrobial Feculent Meningitis With Detection of <i>Slackia exigua</i> in the Cerebrospinal Fluid of a Patient With Advanced Rectal Carcinoma
Authors: Johannes Bükki, Hagen B. Huttner, De-Hyung Lee, Jonathan Jantsch, Rolf Janka, Christoph Ostgathe
Journal: Journal of Clinical Oncology (2011)
Mitral valve prolapse.
Authors: R B Devereux, J K Perloff, N Reichek, M E Josephson
Journal: Circulation (1976)

For half a century the systolic click and late systolic murmur lay dormant as innocent auscultatory curiosities. The thirteen years since Barlow related these phenomena to mitral leaflet prolapse have witnessed an astonishing information explosion. We have sought to bring together the accumulated data in this review. An Historical Perspective traces the evolution from the now abandoned "pericardial" or "extracardiac" phases, through the leafletchordal phase (redundancy), the myocardial phase (segmental left ventricular contraction abnormalities), to the anular phase (dilatation and faulty systolic contraction). Functional Anatomy is dealt with in terms of pathology, pathophysiology, hemodynamics, angiocardiography, echocardiography, and physical and pharmacological interventions. Clinical Manifestations are concerned with prevalence, natural history, symptoms, physical signs, electrocardiographic abnormalities and roentgen fingings. The four Major Complications- sudden death, infective endocarditis, spontaneous rupture of chordae tendineae, and progressive mitral regurgitation- are examined. Associated Cardiac Diseases, i.e., Marfan's syndrome, ostium secundum atrial septal defect and atherosclerotic coronary artery disease, are discussed, and a section on Treatment deals chiefly with prophylaxis for infective endocarditis and the management of arrhythmias and chest pain. A final section on Evolving Information considers etiologic concepts, the nature of left ventricular contration abnormalities, the cause of chest pain, the relationship to Marfan's syndrome and ostium secundum atrial septal defect, and the effect of aging and sex differences on leaflet chordal redundancy.
Follow-up Survey of Clubfoot
Authors: G. Dean MacEwen
Journal: JAMA (1961)

The results of treatment in cases of clubfoot have been observed in 149 patients treated in a single institution during the past 20 years. This study includes patients who are now over five years of age and who returned for clinical and roentgenologic evaluation. The 62 patients who returned represented a total of 96 cases of clubfoot. Of the 96 cases, 77 were treated by the Kite plaster method; 19 were treated with manipulations, plaster casts, and Denis Browne splints. Thirty-two operative procedures were performed on the 96 feet. Excellent or good results were obtained in 72 per cent of the cases treated by plaster casts and the indicated soft tissue surgery. Night splints are important in the prevention and control of recurrences.
Cost-Effectiveness of Proton-Pump Inhibition Before Endoscopy in Upper Gastrointestinal Bleeding
Authors: Salman Al–Sabah, Alan N. Barkun, Karl Herba, Viviane Adam, Carlo Fallone, Serge Mayrand, Gilles Pomier–Layrargues, Wendy Kennedy, Marc Bardou
Journal: Clinical Gastroenterology and Hepatology (2008)
Nasal Sprays and Perforation of the Nasal Septum
Authors: Elaine P. Schoelzel
Journal: JAMA (1985)

To the Editor.—  We think it important to bring to the attention of physicians the fact that in the past two years we have seen eight patients with perforated nasal septa.  Of these, four patients were using beclomethasone dipropionate nasal spray before observation of their defect. One patient was using flunisolide nasal spray, one had been using a decongestant nasal spray for many years, and two had no history of using nasal sprays of any sort at the time the defect was noted. None of the patients had a history of cocaine use, and none of them were exposed to wood dust in their occupations.  For several of these patients, the observation was made that nosebleeds or crusting of the septal membrane was present before the observation of the septal defects. In a written communication from the Schering Corporation, Kenilworth, NJ, dated May 11, 1984, the correspondent (Lynn Britton, PharmD,
Vascular Dynamics in Liver Scan ???Hot Spot???
Authors: C E HENKE, J M WOLFF, R B SHAFER
Journal: Clinical Nuclear Medicine (1978)

Recently, we observed three examples of a focal area of increased activity “hot spot” in the region of the porta hepatis. A review of the literature on this observation has identified it with a variety of causes commonly associated with alteration in superior vena cava (SVC) and hepatic circulatory dynamics. To investigate this alteration in hepatic circulatory dynamics, radionuclide 99 mTc-macroaggregated albumin (MAA)) venacavograms, contrast venacavograms, CT scans, tissue needle biopsy, open surgical biopsy and autopsy were used in these patients. Two additional patients with known mediastinal masses, but with normal or areas of decreased activity on their liver scans, were evaluated by the same methods. The anatomy involved in altered SVC circulation and collateral shunting through the porta hepatis venous circulation producing the “hot spot” was analyzed from radionuclide flow patterns and liver scans. All three patients had SVC or subclavian compression by extrinsic neoplastic masses, creating increased collateral flow through the porta hepatis. Individual variations in collateral shunt patterns were observed. We concluded from our observations that important factors involved in the creation of the liver scan “hot spot” were: 1) site of SVC or subclavian vein compression; 2) degree of SVC or subclavian obstruction; and 3) individual variation in venous collateral patterns.
Prognostic significance and natural history of left ventricular thrombi in patients with acute anterior myocardial infarction: a two-dimensional echocardiographic study.
Authors: P Spirito, P Bellotti, F Chiarella, S Domenicucci, A Sementa, C Vecchio
Journal: Circulation (1985)

Fifty-eight patients with transmural anterior myocardial infarction were prospectively studied with serial two-dimensional echocardiography to determine the clinical implications and prognostic significance of detection of left ventricular thrombus during acute myocardial infarction, the incidence of systemic embolization, and the possible occurrence of spontaneous regression of left ventricular thrombi. Patients were not treated with anticoagulants or platelet inhibitors during the acute phase of infarction or during follow-up. Two-dimensional echocardiograms were obtained within 24 hr of myocardial infarction, every 24 hr until day 5, every 48 hr until day 15, and every month for a follow-up of 2 to 11 months (mean 7), in the surviving patients; a total of 774 echocardiograms were obtained. Left ventricular thrombi were identified in 24 (41%) of the 58 study patients, and developed within 48 hr of infarction in 11 of these patients. Ten (91%) of the 11 patients with early thrombus formation died during hospitalization or during follow-up, while only two (15%) of the 13 who developed a thrombus after 48 hr of infarction died (p less than .005). Incidence of Killip class III or IV, total lactic dehydrogenase values, and extent of wall motion abnormalities were significantly higher in patients who developed a thrombus within 48 hr of infarction than in patients without thrombus. On the other hand, in patients who developed a thrombus after 48 hr of infarction, these parameters were not significantly different from those in patients who did not develop a thrombus. Spontaneous regression of thrombi was documented in three (20%) of the 15 patients who survived the acute phase of myocardial infarction.(ABSTRACT TRUNCATED AT 250 WORDS)
Multicolor Upconversion Nanoparticles for Protein Conjugation
Authors: Stefan Wilhelm, Thomas Hirsch, Wendy M. Patterson, Elisabeth Scheucher, Torsten Mayr, Otto S. Wolfbeis
Journal: Theranostics (2013)

We describe the preparation of monodisperse, lanthanide-doped hexagonal-phase NaYF 4 upconverting luminescent nanoparticles for protein conjugation.Their core was coated with a silica shell which then was modified with a poly(ethylene glycol) spacer and N-hydroxysuccinimide ester groups.The nanoparticles were characterized by transmission electron microscopy, Raman spectroscopy, X-ray diffraction, and dynamic light scattering.The N-hydroxysuccinimide ester functionalization renders them highly reactive towards amine nucleophiles (e.g., proteins).We show that such particles can be conjugated to proteins.The protein-reactive UCLNPs and their conjugates to streptavidin and bovine serum albumin display multicolor emissions upon 980-nm continuous wave laser excitation.Surface plasmon resonance studies were carried out to prove bioconjugation and to compare the affinity of the particles for proteins immobilized on a thin gold film.
Thioridazine-Induced Torsade de Pointes
Authors: Andrew J. Kemper
Journal: JAMA (1983)

Thioridazine (Mellaril) hydrochloride cardiotoxicity is manifested by bradycardia and prolongation of the QT interval. The latter predisposes to atypical ventricular tachycardia (torsade de pointes) when premature ventricular depolarizations occur during the prolonged QT interval. Isoproterenol hydrochloride infusion, which increases the heart rate and shortens the QT interval, is a theoretically advantageous therapeutic modality for use in this situation. This report describes a case of thioridazine-induced torsade de pointes that was successfully managed with isoproterenol infusion after therapy with other agents was unsuccessful. This mode of therapy should be used with caution, but it may be lifesaving in psychiatric or community hospitals where temporary cardiac pacemaker insertion is not performed.
Topography of Lymph Node Metastases in Prostate Cancer Patients Undergoing Radical Prostatectomy and Extended Lymphadenectomy: Results of a Combined Molecular and Histopathologic Mapping Study
Authors: Matthias M Heck, Margitta Retz, Miriam Bandur, Marc Souchay, Elisabeth Vitzthum, Gregor Weirich, Martin Mollenhauer, Tibor Schuster, Michael Autenrieth, Hubert Kübler, Tobias Maurer, Mark Thalgott, Kathleen Herkommer, Jürgen E Gschwend, Roman Nawroth
Journal: European Urology (2013)
Silica Microcapsules for Long‐Term, Robust, and Reliable Room Temperature RNA Preservation
Authors: Michela Puddu, Wendelin J. Stark, Robert N. Grass
Journal: Advanced Healthcare Materials (2015)

As a consequence of the latest revolutionary discoveries on its functions, RNA is certainly the hottest topic at the moment, being an exceptional tool in biology as well as in medicine. For the various applications, a proper RNA storage is required to prevent the degradation of this extremely unstable molecule. Here a novel freezing‐free RNA storage strategy is presented, based on its encapsulation in silica spheres. The silica microcapsules protect the RNA by providing a water‐free environment. In this way RNA can be safely stored for prolonged periods of time at ambient and elevated temperatures, maintaining its original integrity, as proved by gel‐electrophoresis, capillary electrophoresis, and real‐time reverse transcription‐polymerase chain reaction (RT‐qPCR). The RNA degradation rate at 65 °C in silica microcapsules is approximately ten times smaller in comparison to dry RNA samples or to samples stored in RNAstable matrix, a commercially available product. Moreover, RNA half‐life at 65 °C is nearly identical to that of DNA within the silica microcapsules. Samples intended for use in gene expression are compatible with further analysis (RT‐qPCR, Sanger sequencing). The novel storage technology permits to safely handle, store, and transport RNA samples, avoiding the expensive shipments and the problems of space presented by freezing‐based strategies.
A chimeric antigen receptor against prostate-specific membrane antigen, a tumor vasculature target
Authors: Stephen P Santoro, Soorin Kim, Dimitrios Alatzoglou, Daniel J Powell, George Coukos
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts The tumor endothelium plays a complex role in cancer development. Aberrant blood vessels provide structural support for the tumor, a barrier to immune infiltration, and also serve as a source of pro-tumorigenic signals. In accordance with their atypical function, surface protein
Morphological features of naevoid melanoma: results of a multicentre study of the International Dermoscopy Society
Authors: C. Longo, S. Piana, A. Marghoob, S. Cavicchini, P. Rubegni, C. Cota, G. Ferrara, A.M. Cesinaro, A. Baade, P.L. Bencini, F. Mantoux, Z.P. Mijuskovic, M.A. Pizzichetta, I. Stanganelli, C. Carrera, G.L. Giovene, S. Ranasinghe, I. Zalaudek, A. Lallas, E. Moscarella, F. Specchio, P. Pepe, G. Pellacani, G. Argenziano
Journal: British Journal of Dermatology (2014)

Naevoid melanoma (NeM), a rare variant of melanoma, can be difficult to detect as its clinical and histopathological morphology can simulate a naevus.To describe the clinical and dermoscopic features associated with NeM.Lesions with a histopathological diagnosis of NeM were collected via an e-mail request sent to all members of the International Dermoscopy Society. All lesions were histopathologically reviewed and only lesions fulfilling a set of predefined histopathological criteria were included in the study and analysed for their clinical and dermoscopic features.Twenty-seven of 58 cases (47%) fulfilled the predefined histopathological criteria for NeM and were included in the study. Clinically, 16 of the 27 NeMs presented as a nodular lesion (59%), eight (30%) as plaque type and three (11%) as papular. Analysis of the global dermoscopic pattern identified three types of NeM. The first were naevus-like tumours (n = 13, 48%), typified by a papillomatous surface resembling a dermal naevus. In these lesions local dermoscopic features included irregular dots/globules (46%), multiple milia-like cysts (38%) and atypical vascular structures (46%). The second type were amelanotic tumours (n = 8, 30%), typified by an atypical vascular pattern (75%). The third type consisted of tumours displaying a multicomponent pattern (n = 4, 15%), characterized by classical local melanoma-specific criteria. Two lesions (7%) were classified as mixed-pattern tumours as they did not manifest any of the aforementioned patterns.While NeMs may be clinically difficult to differentiate from naevi, any papillomatous lesion displaying dermoscopically atypical vessels and/or irregular dots/globules should prompt consideration for the possible diagnosis of NeM.
Wanted: stress monkeys
Authors: Des Spence
Journal: BMJ (2007)

I ran, under pursuit. His hot breath was on my neck, but my two extra years kept me those important few metres ahead of my bloody and swearing younger brother. It was an accident. And of course a pitchfork through the hand is going to hurt a bit, but this was nothing to the time he was knocked unconscious by a falling concrete block: his head wound eventually stopped bleeding and Mum let him sleep it off. Farm work was dangerous. People got gored by cows, kicked by horses, crushed under bales, and sucked down into slurry pits. …