tbuckley/cabot-search huggingface dataset:
Maintenance of Certification
Authors: Michael Kelley
Journal: Annals of Internal Medicine (2015)

Letters6 January 2015Maintenance of CertificationMichael Kelley, MDMichael Kelley, MDFrom Zayed Military Hospital, Abu Dhabi, United Arab Emirates.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5040 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read Centor and colleagues' editorial (1) with great interest. I am a medicine–pediatrics guy who quit my private practice of 18 years to work overseas. Largely by accident, I ended up working in a mid-sized emergency department (ED). For that reason, I have spent many hours reviewing ED material. Besides using ultrasonography as part of the patient examination, the other interesting thing that these ED folks have is Free Open Access Medical Education (FOAMed), a grassroots, homegrown phenomenon that provides free ED learning materials. Bright physicians put together podcasts, literature reviews, and practice tips and post ...Reference1. Centor RM, Fleming DA, Moyer DV. Maintenance of certification: beauty is in the eyes of the beholder [Editorial]. Ann Intern Med. 2014;161:226-7. [PMID: 24821483] doi:10.7326/M14-1014 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Zayed Military Hospital, Abu Dhabi, United Arab Emirates.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L14-0499. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMaintenance of Certification: Beauty Is in the Eyes of the Beholder Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification: Beauty Is in the Eyes of the Beholder Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Edward Ringel Maintenance of Certification Donald Trainor Maintenance of Certification Robert B. Copeland Maintenance of Certification Leonard Johnson Maintenance of Certification Antoinette Spevetz Maintenance of Certification Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Leonard Johnson Maintenance of Certification Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Antoinette Spevetz Maintenance of Certification Robert B. Copeland Maintenance of Certification Donald Trainor Maintenance of Certification Edward Ringel Metrics 6 January 2015Volume 162, Issue 1Page: 77KeywordsConflicts of interestDisclosureMedical educationMotivationUltrasound imaging ePublished: 6 January 2015 Issue Published: 6 January 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
It takes two to tango: cigarette smoke partners with viruses to promote emphysema
Authors: Rubin M. Tuder, Jeong H. Yun
Journal: Journal of Clinical Investigation (2008)

Viruses constitute a constant and renewed threat to humans. Not only do viruses cause disease directly due to their tissue tropism and pathogenicity, but they have also been linked to autoimmunity. In their study in this issue of the JCI, Kang et al. show that exposure to cigarette smoke induces alterations in the innate immune response to viral infection and that these changes hasten alveolar destruction characteristic of emphysema in mice (see the related beginning on page 2771). This study builds on evidence that patients with chronic obstructive pulmonary disease have clinical exacerbations associated with viral or bacterial infections, which lead to worsened lung function and increased mortality. This novel paradigm may aid related genetic, biomarker, and therapeutic developments and provides important insights into the pathogenesis of emphysematous lung destruction.
A Molecular Signature in Superficial Bladder Carcinoma Predicts Clinical Outcome
Authors: Lars Dyrskjøt, Karsten Zieger, Mogens Kruhøffer, Thomas Thykjaer, Jens L. Jensen, Hanne Primdahl, Natasha Aziz, Niels Marcussen, Klaus Møller, Torben F. Ørntoft
Journal: Clinical Cancer Research (2005)

Abstract Purpose: Cancer of the urinary bladder is a common malignant disease in the western countries. The majority of patients presents with superficial tumors with a high recurrence frequency, a minor fraction of these patients experience disease progression to a muscle invasive stage. No clinical useful molecular markers exist to identify patients showing later disease progression. The purpose of this study was to identify markers of disease progression using full-genome expression analysis. Experimental Design: We did a full-genome expression analysis (59,619 genes and expressed sequence tags) of superficial bladder tumors from 29 bladder cancer patients (13 without later disease progression and 16 with later disease progression) using high-density oligonucleotide microarrays. We used supervised learning for identification of the optimal genes for predicting disease progression. The identified genes were validated on an independent test set (74 superficial tumor samples) using in house-fabricated 60-mer oligonucleotide microarrays. Results: We identified a 45-gene signature of disease progression. By monitoring this progression signature in an independent test set, we found a significant correlation between our classifications and the clinical outcome (P &amp;lt; 0.03). The genes identified as differentially expressed were involved in regulating apoptosis, cell differentiation, and cell cycle and hence may represent potential therapeutic targets. Conclusions: Our results indicate that it may be possible to identify patients with a high risk of disease progression at an early stage using a molecular signature present already in the superficial tumors. In this way, better treatment and follow-up regimens could be assigned to patients suffering from superficial bladder cancer.
Wernicke's encephalopathy in a funny patient
Authors: W Kittisupamongkol
Journal: Journal of the Royal Society of Medicine (2007)

Sojer and colleagues describe a diabetic patient presenting with a month of periodic cognitive impairment due to hypoglycaemia.1 However, a sentence of indispensable personal history should have been included. Significant alcohol consumption could raise a possibility of Wernicke's encephalopathy. This disease is often unrecognized but detrimental if left untreated. The classic triad of mental status change, ophthalmoplegia and truncal ataxia is present in only 16% of patients.2 Failure to include this encephalopathy among differentials of mental status change in such patients and to give intravenous thiamine before glucose accordingly in the setting of hypoglycaemia would lead the patient to worsening status.2

Last but not least, I have seen quite a few alcoholics, and have learnt that a practical question should be ‘when was your last drink?’ rather than ‘do you use alcohol?’
Hospital Events Associated With Adverse Events and Substandard Care
Authors: Bertrand M. Bell
Journal: JAMA (1991)

<h3>To the Editor.</h3> —The article by Brennan et al,<sup>1</sup>"Hospital Characteristics Associated With Adverse Events and Substandard Care," suggested an approach to measuring quality of care in hospitals that may indeed be an important improvement on existing methods. Their findings demonstrated consequential differences in the occurrence of AEs and AEs associated with negligence in primary teaching hospitals and among minority patients, as compared with other subjects. The care of patients in primary teaching hospitals and hospitals that care for minority patients is heavily dependent on house staff, and this important factor, a vital variable in evaluating quality of care, was not considered in their study. The findings and the recommendations of the New York State Committee,<sup>2</sup>which I chaired, led to state regulations limiting the working hours of residents but, of much greater importance, led to the setting of new rules, which attempt to improve the supervision of
Hypertension in Renal Transplant Recipients: Role of Bilateral Nephrectomy
Authors: S. L. Cohen
Journal: BMJ (1973)

Of 81 transplanted kidneys which functioned for six months or more 59 were transplanted to bilaterally nephrectomized recipients and 22 to recipients who retained their own kidneys. There was an excess of hypertension in the non-nephrectomized group (17/22) as compared to 24/59 in the nephrectomized patients, though renal function was better in the non-nephrectomized group. Hypertension became much easier to control in two of the four non-nephrectomized recipients in whom bilateral nephrectomy was performed after transplantation when renal function was good.
A Novel Phycobiliprotein Alleviates Allergic Airway Inflammation by Modulating Immune Responses
Authors: Chun-Jung Chang, Yao-Hsu Yang, Yu-Chih Liang, Chiao-Juno Chiu, Kuan-Hua Chu, Hung-Non Chou, Bor-Luen Chiang
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

it has been claimed that phycocyanin exhibits pharmaceutical functions in inhibiting histamine release and leukotriene biosynthesis. In allergic asthma, these inflammatory mediators are crucial for disease progression.the aim of this study was to evaluate the therapeutic potential of R-phycocyanin (R-PC) against allergic airway inflammation.mouse bone marrow-derived dendritic cells (BMDCs) were used to evaluate the immunomodulatory functions of R-PC. In addition, an airway inflammatory model was used to evaluate the therapeutic potential of R-PC.R-PC treatment resulted in a decrease of endocytosis, increase of costimulatory molecule expression, and enhancement of interleukin-12 production in mouse BMDCs. Moreover, R-PC-treated cultured dendritic cells were able to promote CD4(+) T-cell stimulatory capacity and increase interferon-γ expression in CD4(+) T cells. Intraperitoneal administration of R-PC suppressed ovalbumin (OVA)-induced airway hyperresponsiveness, serum levels of OVA-specific IgE and IgG1, eosinophil infiltration, Th2 cytokine levels, and eotaxin in bronchoalveolar lavage fluid of mice. Antibody against Toll-like receptor-4 was able to inhibit R-PC-induced IL-12 p70 production. Moreover, inhibition of nuclear factor-κB (NF-κB) by helenalin and inhibition of the JNK pathway by JNK inhibitor II inhibited R-PC-induced IL-12 p70 production. Western blotting and electrophoretic mobility shift assays showed that R-PC augmented phosphorylation of the inhibitors of NF-κB and inhibitors of NF-κB kinase and facilitated NF-κB activity.our data demonstrated that R-PC promoted activation and maturation of cultured dendritic cells and skewed the immunological function toward Th1 activity. Therefore, R-PC may have potential in regulating immune responses and application in reducing allergic asthma.
Atrophy of the Heart: A Correlative Study of Eighty-Five Proved Cases
Authors: H. K. HELLERSTEIN, D. SANTIAGO-STEVENSON
Journal: Circulation (1950)

This critical study of atrophy of the heart is based upon a detailed analysis of 85 proved cases. The clinical, roentgenographic and electrocardiographic features are considered to be sufficiently distinctive to facilitate antemortem recognition. The clinical implications of atrophy of the heart and the reversibility of atrophy and hypertrophy are emphasized.
Author rectifies omission: health behaviour change in the developing world
Authors: Stephen Rollnick
Journal: BMJ (2005)

Endovascular repair is not worse than open repair of abdominal aortic aneurysmsEditor-The title and interpretation of the EVAR trial results in the POEM are misleading and incorrect. 1Mortality figures were quoted both as aneurysm related and all cause deaths.The 30 day mortality was 1.7% in the EVAR group, which is significantly lower than 4.7% in the open repair group.Surprisingly, the POEM somehow interpreted 30 day mortality to be less than 1% for both groups, which is clearly an error.The confidence intervals (odds ratio 0.35, 95% confidence interval 0.16 to 0.77, P = 0.009) make type I error unlikely.If preintervention deaths are added to the figures 30 day mortality was calculated at 3.5% for endovascular repair and 7.1% for open surgery. 2 The advantage of endovascular repair is sustained at four years, with 4% aneurysm related deaths in the EVAR group compared with 7% in the open repair group.This confers a 3% absolute reduction in aneurysm related mortality.The all cause mortality rate was comparable in both groups at four years.Endovascular repair offers a 30 day lower risk treatment compared with open surgery in patients who are medically fit with an abdominal aortic aneurysm.Compared with open repair, endovascular repair offers no advantage with respect to all cause mortality and health related quality of life; and is more expensive; however, it confers a 3% improved aneurysm related survival which persists at four years.The POEM's message that endovascular repair is worse than open repair is inaccurate and not evidence based.
Official Autopsy Report on President Kennedy
Authors: R. M. Failing
Journal: JAMA (1965)

<h3>To the Editor:—</h3> After reading the "Official Autopsy Report on President Kennedy" (FROM OTHER PAGES,<i>JAMA</i><b>190</b>, Oct 26, 1964, adv p 98) I wonder if this represents the complete autopsy protocol? It seems to be the complete report submitted, but it certainly would appear to be a grossly incomplete record. The forensic pathologist prides himself on his thoroughness in the positive findings, in the pertinent negative findings, and in the recording of other normal and abnormal findings that may be totally unrelated to the cause and mode of death. For instance, this "complete" record with its supplementary report fails to mention what the gross findings were with regard to such obvious and easily identifiable organs as the liver, spleen, kidneys, pancreas, thyroid, and adrenals. Some of these organs must have been found for they are mentioned under the section heading, "Microscopic Examination." Others apparently were not found, for no
Nitric Oxide
Authors: Weiqun Shen, Thomas H. Hintze, Michael S. Wolin
Journal: Circulation (1995)

Background Nitric oxide (NO) is known to be an inhibitor of mitochondrial function. However, the physiological significance of endothelium-derived NO in the control of tissue respiration is not established. Methods and Results Tissue O 2 consumption by skeletal muscle slices of the triceps brachii of normal dogs was measured with a Clark-type O 2 electrode/tissue bath system at 37°C. S -Nitroso- N -acetylpenicillamine (SNAP), carbachol (CCh), or bradykinin (BK) decreased tissue O 2 consumption by 12±3% to 55±8%, 15±6% to 36±11%, or 21±5% to 42±4% at doses of 10 −7 to 10 −4 mol/L, respectively. The effects of both CCh and BK but not SNAP were eliminated by nitro- l -arginine (NLA, 10 −4 mol/L), consistent with SNAP decomposing to release NO and both CCh and BK stimulating endogenous NO production from l -arginine. Oxygen consumption was also decreased by 8-bromo-cGMP. The mitochondrial uncoupler dinitrophenol blocked the effects of 8-bromo-cGMP but only slightly altered those of SNAP, indicating that the major site of action of NO is the mitochondria. In normal, chronically instrumented, resting conscious dogs, blockade of NO synthase by NLA increased mean arterial pressure by 28±2.5 mm Hg and hind limb vascular resistance by 114±12% and decreased blood flow by 39±3%. Most important, NLA also increased O 2 uptake by 55±9% in hind limb skeletal muscle ( P &lt;.05), associated with decreases in P o 2 and O 2 saturation and an increase in reduced hemoglobin in hind limb venous blood. Conclusions Our results indicate that NO release from vascular endothelial cells appears to play an important physiological role in the regulation of tissue mitochondrial respiration in skeletal muscle and perhaps other organ systems.
Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia
Authors: Shmuel Fuchs, Richard Baffour, Yi Fu Zhou, Matie Shou, Anthony Pierre, Fermin O Tio, Neil J Weissman, Martin B Leon, Stephen E Epstein, Ran Kornowski
Journal: Journal of the American College of Cardiology (2001)
CIRCULATING SURFACTANT PROTEINS, DYSPNEA, AND MARKERS OF CONGESTION IN ACUTE DECOMPENSATED HEART FAILURE: REPORT FROM THE DIURETIC OPTIMIZATION STRATEGIES EVALUATION (DOSE) STUDY
Authors: Yee Weng Wong, Kevin Anstrom, Steven McNulty, Adrian Hernandez, G. Michael Felker
Journal: Journal of the American College of Cardiology (2014)
Cutaneous manifestations of cystic fibrosis: possible role of cryoglobulins
Authors: B.Z. GARTY, T. SCANLIN, D.P. GOLDSMITH, M. GRUNSTEIN
Journal: British Journal of Dermatology (1989)

A 13‐year‐old girl with cystic fibrosis (CF), severe lung disease, purpura on the lower extremities and with elevated serum mixed cryoglobulins is described. The possible relationship of the purpura in CF with cryoglobulinaemia is discussed.
A Revolution in Medical Care
Authors: Walter C. Bornemeier
Journal: JAMA (1970)

I am sure that all of us were fascinated in our youth by Washington Irving's story of Rip Van Winkle. When I first read it, I thought the amazing part was that Rip could sleep for 20 years. Now I know the really amazing part was that he slept through a revolution. When Rip went to sleep, we were a British Colony. When he awakened, the nation was a republic. We are living through a revolution in health care, and I am sure that physicians, the press, and the community are well aware of it. In this address I shall consider some of its causes and effects, and propose some fundamental possible solutions to the problems this revolution has created. Medical care changed from an art to a science during the transition from the preantibiotic days before World War II, to the gradual emergence of antibiotics in abundance. The famous
William B. Ober, MD
Authors: Victor Tchertkoff
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Institute of Medicine identifies 12 indicators to improve US health
Authors: B. Roehr
Journal: BMJ (2011)

The US Institute of Medicine (IOM) has identified 12 key indicators, including reducing calorie intake from solid fats and added sugars, and 24 objectives as priorities for improving the health of the nation over the next decade. 

The Department of Health and Human Services requested and funded the development of the report, which was published on 15 March. It reviews and prioritises recommendations made in Healthy People 2020 (www.healthypeople.gov/2020/), the latest in a series of forward looking blueprints to improve the health of US citizens over the next 10 years.

The goals “have grown increasingly multiplied and complicated” over the four editions of the document, …
Release of vitamin B12—binding protein by human leukocytes in vitro
Authors: José Corcino, Stephen Krauss, Samuel Waxman, Victor Herbert
Journal: Journal of Clinical Investigation (1970)

Human granulocytes (G) contain a vitamin B12-binding protein (B12BP). There is evidence that chronic myelogenous leukemia leukocytes (CMLL) may synthesize B12BP. Our prior studies suggested that intact, living intravascular G synthesize and release such protein into extracellular compartments in vivo.
spib is required for primitive myeloid development in Xenopus
Authors: Ricardo M. B. Costa, Ximena Soto, Yaoyao Chen, Aaron M. Zorn, Enrique Amaya
Journal: Blood (2008)

Abstract Vertebrate blood formation occurs in 2 spatially and temporally distinct waves, so-called primitive and definitive hematopoiesis. Although definitive hematopoiesis has been extensively studied, the development of primitive myeloid blood has received far less attention. In Xenopus, primitive myeloid cells originate in the anterior ventral blood islands, the equivalent of the mammalian yolk sac, and migrate out to colonize the embryo. Using fluorescence time-lapse video microscopy, we recorded the migratory behavior of primitive myeloid cells from their birth. We show that these cells are the first blood cells to differentiate in the embryo and that they are efficiently recruited to embryonic wounds, well before the establishment of a functional vasculature. Furthermore, we isolated spib, an ETS transcription factor, specifically expressed in primitive myeloid precursors. Using spib antisense morpholino knockdown experiments, we show that spib is required for myeloid specification, and, in its absence, primitive myeloid cells retain hemangioblast-like characteristics and fail to migrate. Thus, we conclude that spib sits at the top of the known genetic hierarchy that leads to the specification of primitive myeloid cells in amphibians.
Methods for Prevention of Tubercular Infection at Mount St. Rose Sanatorium.
Authors: William Porter
Journal: JAMA (1902)

Schauta docs not find favor with Pozzi, though it was carried out two or three weeks ago in his service by Jonnesco of Buchar¬ est.The importance of removing the glands seems to have been exaggerated, as they are rarely a cause of serious complications or death, which is generally due to hemorrhage, chronic septi¬ cemia or uremia.
Minimally invasive techniques in the treatment of saphenous varicose veins
Authors: Tamar Nijsten, Renate R. van den Bos, Mitchel P. Goldman, Michael A. Kockaert, Thomas M. Proebstle, Eberhard Rabe, Neil S. Sadick, Robert A. Weiss, Martino H.A. Neumann
Journal: Journal of the American Academy of Dermatology (2008)
Tryptase and histamine as markers to evaluate mast cell activation during the responses to nasal challenge with allergen, cold, dry air, and hyperosmolar solutions
Authors: David Proud, Graham S. Bailey, Robert M. Naclerio, Curt J. Reynolds, Alvaro A. Cruz, Peyton A. Eggleston, Lawrence M. Lichtenstein, Alkis G. Togias
Journal: Journal of Allergy and Clinical Immunology (1992)
Adenocarcinoma With Epidermal Growth Factor Receptor Gene Mutations in Three Siblings
Authors: Tomohiro Sakakibara, Yasuo Saijo, Tatsuro Fukuhara, Kazunori Gomi, Akira Inoue, Osamu Ishimoto, Shunichi Sugawara, Toshihiro Nukiwa
Journal: Journal of Thoracic Oncology (2008)