tbuckley/cabot-search huggingface dataset:
A Chimeric RNA Characteristic of Rhabdomyosarcoma in Normal Myogenesis Process
Authors: Huiling Yuan, Fujun Qin, Mercedeh Movassagh, Hong Park, Wendy Golden, Zhongqiu Xie, Peng Zhang, Jeffrey Sklar, Hui Li
Journal: Cancer Discovery (2013)

Abstract Gene fusions and their chimeric products are common features of neoplasia. Given that many cancers arise by the dysregulated recapitulation of processes in normal development, we hypothesized that comparable chimeric gene products may exist in normal cells. Here, we show that a chimeric RNA, PAX3–FOXO1, identical to that found in alveolar rhabdomyosarcoma, is transiently present in cells undergoing differentiation from pluripotent cells into skeletal muscle. Unlike cells of rhabdomyosarcoma, these cells do not seem to harbor the t(2;13) chromosomal translocation. Importantly, both PAX3–FOXO1 RNA and protein could be detected in the samples of normal fetal muscle. Overexpression of the chimera led to continuous expression of MYOD and MYOG—two myogenic markers that are overexpressed in rhabdomyosarcoma cells. Our results are consistent with a developmental role of a specific chimeric RNA generated in normal cells without the corresponding chromosomal rearrangement at the DNA level seen in neoplastic cells presumably of the same lineage. Significance: A chimeric fusion RNA, PAX3–FOXO1, associated with alveolar rhabdomyosarcoma, is also present in normal non-cancer cells and tissues. Its transient expression nature and the absence of t(2;13) chromosomal translocation are consistent with a posttranscriptional mechanism. When constantly expressed, PAX3–FOXO1 interfered with the muscle differentiation process, which presumably contributes to tumorigenesis. Cancer Discov; 3(12); 1394–1403. ©2013 AACR. This article is highlighted in the In This Issue feature, p. 1317
Bronchial Carcinoma with Hypercalcaemia Simulating Cerebral Metastases
Authors: N. J. Strickland, A. M. Bold, W. E. Medd
Journal: BMJ (1967)

ClarkMEDICAL by techniques based on absorption, but the cost and main- tenance of apparatus of this type make their use impracticable.During the course of several months, usage of this system has proved satisfactory, and we regard this as an acceptable technique for the removal of oil contamination.Though the filters do not appear to be passing detectable oil after several months' use, it seems reasonable to change the filter elements, costing about 30s.each, at quarterly intervals. SummaryPatients in an intensive therapy unit were being directly ventilated with air from a piped system.It was suspected that this air could be contaminated by oil mist from the compressors used in the system.By passing the compressed air through a collection device, it was possible to extract oil in microgram quantities, which were subsequently estimated by spectrofluorimetry.Oil contamination was studied under various working conditions.Because of the implication of oil mist contamination, successful modifications were made to the air-supply system.Even when collections have been made for several days, oil contamination is now below the level of detection.We would like to acknowledge the co-operation of the British Oxygen Company, and in particular Messrs. J.
Temporomandibular Joint Gout
Authors: H. H. Chun
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Hyperuricemia due to reduced urate secretion in patients not overproducing uric acid is frequently encountered among Filipinos, Chinese, and Japanese. Temporomandibular joint pain appearing in this susceptible population, particularly after thiazide therapy as well as surgery and the other usual precipitating events, should suggest an episode of acute gouty arthritis. This is a very common and remediable cause of temporomandibular joint pain dysfunction syndrome (224:622, 1973) occurring among populations with these ethnic backgrounds.
Impact of Lesion Sets on Mid-Term Results of Surgical Ablation Procedure for Atrial Fibrillation
Authors: Francesco Onorati, Giovanni Mariscalco, Antonino Salvatore Rubino, Filiberto Serraino, Francesco Santini, Andrea Musazzi, Catherine Klersy, Andrea Sala, Attilio Renzulli
Journal: Journal of the American College of Cardiology (2011)
Role of the General Ophthalmologist
Authors: John C. Hagan
Journal: JAMA (1977)

To the Editor.—  As a board-certified general ophthalmologist, I would like to make the following comments about the prominently displayed abstract on retinal detachment (237:1256, 1977).  It is proper to emphasize the importance of early diagnosis and treatment of retinal detachment. I do not feel it proper or accurate that a retinal detachment case mismanaged by a general ophthalmologist is presented as being typical. Finally, all retinal detachment surgery need not be delivered into the hands of the retinal surgeon. Many general ophthalmologists by virtue of their training, talent, and interest can perform retinal detachment surgery with excellent results.  The interested reader is referred to the original article 1 and my response, 2 which was published without comment by Adams.
Chronic cutaneous disseminated Trichosporon asahii infection in a nonimmunocompromised patient
Authors: Sung-Han Kim, Dong-Hyun Kim, Sei-Ick Joo, Jae-Il Yoo, Hong-Bin Kim, Nam-Joong Kim, Yeong Seon Lee, Myoung-don Oh, Eui-Chong Kim, Hee Chul Eun, Kang-Won Choe
Journal: Journal of the American Academy of Dermatology (2008)
Detecting cheating in written medical examinations
Authors: Gary J Nicholls
Journal: BMJ (2005)

Health inequalities under New Labour Relative rather than absolute gaps are important over time and placeEditor-We agree with Shaw et al that the method of measuring inequality in health outcomes used in setting the government targets is problematic (A Low, UKPHA (UK Public Health Association), 13th annual public health forum, Gateshead, April 2005). 1 However, the government's targets are based on reducing relative gaps in life expectancy and infant mortality. 2 The slope index of inequality (SII) used by Shaw et al measures absolute gaps.
Criminalising healthcare professionals is disproportionate and unlikely to work
Authors: C. Lees
Journal: BMJ (2014)

Bibby argues that wilful neglect should be criminalised. But the devil is in the detail, and the caveats “we would need clarity in the interpretation of ‘wilful’ and thorough evaluation of its impact” and “although legislation will hopefully deter rare and extreme cases” underline how shaky the proposition is.1 Uniquely, UK doctors are subject to multiple jeopardies: civil legal action, …
The Induction of Asthma Attacks by Saline.
Authors: Eugene R. Bleecker
Journal: Annals of Internal Medicine (1968)

s1 May 1968The Induction of Asthma Attacks by Saline.Eugene R. Bleecker, E. R. McFadden Jr., M.D., Thomas Luparello, M.D., Harold A. Lyons, M.D., F.A.C.P.Eugene R. BleeckerSearch for more papers by this author, E. R. McFadden Jr., M.D.Search for more papers by this author, Thomas Luparello, M.D.Search for more papers by this author, Harold A. Lyons, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1184_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe induction of acute attacks of bronchospasm by the use of a placebo was investigated in 40 asthmatic subjects. Each patient was told that he would be inhaling 5 different concentrations of some allergen that he had indicated as the cause of his asthma attacks (for example, dust, pollens, animal danders, etc.). In all cases the substance inhaled was physiologic saline. Measurements of airway resistance (Ra) and thoracic gas volume (TGV) were determined by pressure body plethysmography before and after each inhalation. Ra was converted to its reciprocal conductance (Ga) and expressed as a conductance-thoracic gas volume ratio (Ga/TGV). The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Eugene R. Bleecker; E. R. McFaddenJr., M.D.; Thomas Luparello, M.D.; Harold A. Lyons, M.D., F.A.C.P.Affiliations: Brooklyn, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1184-1184KeywordsAllergensAsthmaAttentionDustInhalationPollen ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Abstract 12247: Infections After Cardiac Surgery: Initial Experience from the Cardiothoracic Surgical Trials Network
Authors: Michael A Acker, Michael Argenziano, John D Puskas, T. B Ferguson, Annetine C Gelijns, Keith Horvath, Marissa A Miller, Stacey Welsh, Ellen Moquete, Kevin N Su, Alan Weinberg, Alan J Moskowitz, Patrick T O'Gara, Eugene H Blackstone
Journal: Circulation (2011)

Objective: Hospital-acquired infections are the most common non-cardiac complication after cardiac surgery, but their true prevalence across a broad range of operations remains unknown. This study ...
Harry Ian Lockett
Authors: T. Phelps
Journal: BMJ (2003)

Former county medical officer Nottinghamshire (b Gillingham, Kent, 1929; q London 1952; DObst RCOG, DPH, FFCM), died from a small bowel infarct on 16 June 2003.​2003.




Figure 1




After a successful career in public health, Harry seized the opportunity presented by yet another reorganisation to take early retirement and pursue his interest in alternative medicine. He studied and practised both homoeopathy and acupuncture, spending some time in China furthering his knowledge of the latter. He was an expert in medieval armour and edge weapons. He leaves a wife, Liz; five children from a previous marriage; and six grandchildren.
Costs of Intensive Care
Authors: PETER MAGNUSSON
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 March 1973Costs of Intensive CarePETER MAGNUSSON, M.D.PETER MAGNUSSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-3-458 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The provocative article by Griner (Ann Intern Med77:501-506, 1972) concerning the higher cost of intensive care unit treatment in the absence of demonstrable material benefit to the patient (that is, longevity) is welcomed and rightfully questions the appropriate role of the intensive care unit. However, the differences between the unit-treated and non-unit-treated patients extend beyond differences in sex distribution and antecedent congestive heart failure. Intubated patients accounted for 14 of 18 of the unit admissions, as compared to 8 of 38 non-unit admissions. Despite Dr. Griner's disclaimer, does this indicate that the patients admitted to the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PETER MAGNUSSON, M.D.Affiliations: Harbor General Hospital Torrance, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInternational Programme for Resource Use in Critical Care (IPOC) - a methodology and initial results of cost and provision in four European countriesThe Bioavailability of Oral NitroglycerinPharmacokinetics and Bioavailability of Intravenous and Topical Nitroglycerin in the Rhesus Monkey: Estimate of Percutaneous First-Pass MetabolismManagement of Stable Effort Angina PectorisUse of Nitrates as Antianginal Agents 1 March 1973Volume 78, Issue 3Page: 458-458KeywordsHeart failureIntensive care units ePublished: 1 December 2008 Issue Published: 1 March 1973 PDF downloadLoading ...
CXCR4 dimerization and β-arrestin–mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome
Authors: Bernard Lagane, Ken Y. C. Chow, Karl Balabanian, Angélique Levoye, Julie Harriague, Thierry Planchenault, Françoise Baleux, Nathalie Gunera-Saad, Fernando Arenzana-Seisdedos, Françoise Bachelerie
Journal: Blood (2008)
Stabilization of the murine gut microbiome following weaning
Authors: Patrick D. Schloss, Alyxandria M. Schubert, Joseph P. Zackular, Kathryn D. Iverson, Vincent B. Young, Joseph F. Petrosino
Journal: Gut Microbes (2012)

Ecologists hypothesize that community structure and stability affect productivity, sensitivity to invasion and extinction, and resilience and resistance to perturbations. Viewed in the context of the gut microbiome, the stability of the gut community is important for understanding the effects of antibiotics, diet change and other perturbations on host health and colonization resistance. Here we describe the dynamics of a self-contained community, the murine gut microbiome. Using 16S rRNA gene sequencing of fecal samples collected daily from individual mice, we characterized the community membership and structure to determine whether there were significant changes in the gut community during the first year of life. Based on analysis of molecular variance, we observed two community states. The first was observed in the 10 days following weaning and the second was observed by 15 days following weaning. Interestingly, these two states had the same bacterial populations, but those populations had different relative abundances in the two states. By calculating the root mean squared distances between samples collected in the early and late states for each mouse, we observed that the late state was more stable than the early state. This increase in stability was not correlated with increased taxonomic richness, taxonomic diversity, or phylogenetic diversity. In the absence of an experimentally induced perturbation, the second community state was relatively constant through 364 days post weaning. These results suggest a high degree of stability in the microbiome once the community reached the second state.
Topical Lidocaine Exaggerates Laryngomalacia during Flexible Bronchoscopy
Authors: DENNIS W. NIELSON, PHILIP L. KU, MARLENE EGGER
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

In 156 infants and children referred for flexible fiberoptic bronchoscopy (FFB) we examined the larynx before and after application of 2% lidocaine solution to see what effect topical anesthesia might have on laryngeal function. All patients received midazolam and nalbuphine intravenously. Using blinded, randomly re-recorded key segments of the original video recordings of bronchoscopy, we used an empirical scoring system (Table 2) to grade signs of laryngomalacia on a scale of 0 to 8 points before and after application of the lidocaine solution. This score was based on the magnitude of collapse of the arytenoids and folding of the epiglottis during inspiration. Topical lidocaine was more likely to result in an increase in signs of laryngomalacia than in a decrease in such signs (p < 0.0001). Younger patients were more likely to have signs of laryngomalacia before topical anesthesia (odds ratio, 1.83). In a group of 10 additional patients, selected for history and physical findings consistent with laryngomalacia, application of a normal saline solution had no effect on the laryngomalacia score, but application of 2% lidocaine solution to the larynx resulted in a significant increase in this score (p < 0.001). Thus, this study has clearly demonstrated that topical anesthesia in infants and children undergoing FFB exaggerates the findings commonly associated with laryngomalacia. Because overestimation of these findings might lead to unnecessary treatment, it is important to examine the larynx and contiguous structures before applying topical anesthesia.
Gamuts in Radiology: Comprehensive Lists of Roentgen Differential Diagnosis
Authors: Lee B. Lusted
Journal: JAMA (1976)

<i>Gamuts</i>is a very interesting and useful book. Radiologists and radiology residents in our department use the book regularly. I recommend it to radiologists and clinicians who wish to look up a complete list of causes of a particular roentgenographic finding or pattern. The word "gamut" is defined as the whole range of anything and, as noted in the Preface, a compilation such as this has not been published previously. Since I have recommended that you use the book I wish to call your attention to several things that I find interesting. The<i>Gamut</i>lists are the result of two experts thinking hard about all the conditions under which certain roentgenographic findings are observed. For instance, you see a solitary calcification in the skull and you start searching your memory bank for all the causes. This is not a book of diagnoses based on relative frequencies derived from a large
Drug Five Years Later
Authors: GERALD L. MANDELL
Journal: Annals of Internal Medicine (1973)

Cephaloridine (Loridine®) is a cephalosporin antibiotic for parenteral use that has antibacterial activity similar to that of cephalothin (Keflin®). Cephaloridine is less painful on intramuscular injection than cephalothin. Doses greater than 4 g daily may be nephrotoxic to normal patients, and smaller doses may damage the kidneys of patients with underlying renal disease or those receiving other nephrotoxic drugs. Therefore renal function should be monitored before and during cephaloridine therapy. Cephaloridine will probably be replaced as "the intramuscular cephalosporin" by new cephalosporin antibiotics that are as well tolerated by the intramuscular route but do not have significant nephrotoxic hazard.
Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia- induced hormonal counterregulation
Authors: R. J. McCrimmon
Journal: Journal of Clinical Investigation (2006)

Recurrent episodes of hypoglycemia impair sympathoadrenal counterregulatory responses (CRRs) to a subsequent episode of hypoglycemia. For individuals with type 1 diabetes, this markedly increases (by 25-fold) the risk of severe hypoglycemia and is a major limitation to optimal insulin therapy. The mechanisms through which this maladaptive response occurs remain unknown. The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors (CRFR1 and CRFR2) play a critical role in regulating the neuroendocrine stress response. Here we show in the Sprague-Dawley rat that direct in vivo application to the ventromedial hypothalamus (VMH), a key glucose-sensing region, of urocortin I (UCN I), an endogenous CRFR2 agonist, suppressed (~55–60%), whereas CRF, a predominantly CRFR1 agonist, amplified (~50–70%) CRR to hypoglycemia. UCN I was shown to directly alter the glucose sensitivity of VMH glucose-sensing neurons in whole-cell current clamp recordings in brain slices. Interestingly, the suppressive effect of UCN I–mediated CRFR2 activation persisted for at least 24 hours after in vivo VMH microinjection. Our data suggest that regulation of the CRR is largely determined by the interaction between CRFR2-mediated suppression and CRFR1-mediated activation in the VMH.
Comparative study of test kits for measurement of rheumatoid factors by the latex fixation test.
Authors: F Klein, M B Janssens, L K van Romunde, G A Eilers
Journal: Annals of the Rheumatic Diseases (1990)

The performance of 14 test kits for the measurement of rheumatoid factors by the latex fixation test was investigated; all results were expressed in IU/ml. Reproducibility and properties of control sera were also studied. It was found that half of the kits did not satisfactorily detect rheumatoid factor levels lower than 25 IU/ml. Most kits performed reasonably well in practice. Positive control sera only rarely met strict requirements. The relative costs did not always have a clear correlation with the quality of the results. The variation caused by differences between kits became acceptable when the results were expressed in IU/ml.
A Critical Analysis of the Clinical Use of Incretin-Based Therapies
Authors: Peter C. Butler, Michael Elashoff, Robert Elashoff, Edwin A.M. Gale
Journal: Diabetes Care (2013)

There is no question that incretin-based glucose-lowering medications have proven to be effective glucose-lowering agents. Glucagon-like peptide 1 (GLP-1) receptor agonists demonstrate an efficacy comparable to insulin treatment and appear to do so with significant effects to promote weight loss with minimal hypoglycemia. In addition, there are significant data with dipeptidyl peptidase 4 (DPP-4) inhibitors showing efficacy comparable to sulfonylureas but with weight neutral effects and reduced risk for hypoglycemia. However, over the recent past there have been concerns reported regarding the long-term consequences of using such therapies, and the issues raised are in regard to the potential of both classes to promote acute pancreatitis, to initiate histological changes suggesting chronic pancreatitis including associated preneoplastic lesions, and potentially, in the long run, pancreatic cancer. Other issues relate to a potential risk for the increase in thyroid cancer. There are clearly conflicting data that have been presented in preclinical studies and in epidemiologic studies. To provide an understanding of both sides of the argument, we provide a discussion of this topic as part of this two-part point-counterpoint narrative. In the point narrative below, Dr. Butler and colleagues provide their opinion and review of the data to date and that we need to reconsider the use of incretin-based therapies because of the growing concern of potential risk and based on a clearer understanding of the mechanism of action. In the counterpoint narrative following the contribution by Dr. Butler and colleagues, Dr. Nauck provides a defense of incretin-based therapies and that the benefits clearly outweigh any concern of risk.
TCT-641 Comparison of Intravascular Ultrasound (IVUS) and Optical Coherence Tomography (OCT) assessment of Coronary Allograft Vasculopathy (CAV) in patients after orthotopic heart transplantation
Authors: Koichiro Matsumura, Rubine Gevorgyan, William M. Suh, Jonathan Tobis
Journal: Journal of the American College of Cardiology (2013)
UNRAVELING PULSATILE TINNITUS IN FMD: A REPORT OF THE UNITED STATES REGISTRY FOR FIBROMUSCULAR DYSPLASIA
Authors: Redah Zainub Mahmood, Jeffrey Olin, Xiaokui Gu, Eva Kline-Rogers, James Froehlich, J. Michael Bacharach, Yung-Wei Chi, Bruce Gray, Michael Jaff, Barry Katzen, Soo Hyun Kim, Pamela Mace, Robert McBane, Aditya Sharma, Christopher White, Heather Gornik
Journal: Journal of the American College of Cardiology (2014)
Role of coronary angioplasty (PTCA) on neutrophil, monocyte and platelet activation and adhesion molecule surface expression
Authors: Carlos V. Serrano, JoséA. Ramires, Margareth Venturinelli, Siguemituso Arie, Elbio D'Amico, Jay Zweier, Protásio L. da Luz
Journal: Journal of the American College of Cardiology (1996)
ELECTRIC SHOCK THERAPY IN THE TREATMENT OF A DEPRESSED PARAPLEGIC
Authors: JOSEPH E. PISETSKY, FRANKLIN S. KLAF
Journal: American Journal of Psychiatry (1958)

A 25-year-old paraplegic with a severe depression and suicidal preoccupation completed a course of 15 electroshock treatments using anectine as a muscle relaxant. There were no complications during the course of the therapy. His depression improved and the suicidal preoccupation disappeared.
Long-term (12-year) gender differences in prognosis after acute myocardial infarction in young (&amp;lt;65 years) and elderly (≥65 years) patients
Authors: S. Gottlieb, M. Benderly, Uri Goldbourt, D. Harpaz, Henrietta Reicher-Reiss, S. Stern, Elieser Kaplinsky, Solomon Behar
Journal: Journal of the American College of Cardiology (1998)