Norfloxacin and Absorption of Magnesium-Aluminum
Authors: Margaret Noyes
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 July 1988Norfloxacin and Absorption of Magnesium-AluminumMargaret Noyes, PharmD, Ron E. Polk, PharmDMargaret Noyes, PharmD, Ron E. Polk, PharmDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-2-168_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Regarding the recent review of norfloxacin (1), we have found that decreased norfloxacin absorption can result from concommitant administration of magnesium-aluminum-containing antacids. We report a case in which this interaction probably led to therapeutic failure.A 75-year-old woman was transferred to our hospital for treatment of presumed Guillain-Barré syndrome. Three weeks earlier, she had been hospitalized for increased muscle weakness. She developed respiratory arrest and became dependent on a ventilator. On admission to our hospital, she was afebrile and had a Foley catheter in place. Supportive care included placement of a nasogastric tube. On the fourth day,...References1. WolfsonHooper JD. Norfloxacin: a new targeted fluoroquinolone anitimicrobial agent. Ann Intern Med. 1988;108:238-51. LinkGoogle Scholar2. HöffkenBornerGlatzelKoeppeLode GKPPH. Reduced enteral absorption of ciprofloxacin in the presence of antacids. Eur J Clin Microbiol. 1985;4:345. CrossrefMedlineGoogle Scholar3. Zeiler H. Influence of pH and human urine on the antibacterial activity of ciprofloxacin, norfloxacin and ofloxacin. Drugs Exp Clin Res. 1985;11:335-8. MedlineGoogle Scholar4. ButlerKunin HC. Evaluation of specific systemic antimicrobial therapy in patients while on closed catheter drainage. J Urol. 1968;100:567-72. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical College of Virginia Virginia Commonwealth University School of Pharmacy Richmond, VA 23298-0581 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRevisiting Oral Fluoroquinolone and Multivalent Cation Drug-Drug Interactions: Are They Still Relevant?In vitro Effects of Magnesium-Aluminum Hydroxide (Maalox) on the Antibacterial Activity of Ciprofloxacin against Clinical Bacterial IsolatesClinically Significant Drug Interactions with AntacidsInteraction Characteristics and Thermodynamic Behaviour of Gatifloxacin by Aluminium HydroxideHigh Rate of Coadministration of Di- or Tri-valent Cation-Containing Compounds With Oral Fluoroquinolones: Risk Factors and Potential ImplicationsCoadministration of Gatifloxacin and Multivitamin Preparation Containing Minerals: Potential Treatment Failure in an Elderly PatientPractical TherapeuticsConcomitant Administration of Drugs Known to Decrease the Systemic Availability of GatifloxacinThe effect of staggered dosing of sucralfate on oral bioavailability of sparfloxacinDecreased In Vitro Fluoroquinolone Concentrations After Admixture With an Enteral Feeding FormulationPharmacokinetics of Gatifloxacin and Interaction with an Antacid Containing Aluminum and MagnesiumCiprofloxacin absorption is impaired in patients given enteral feedings orally and via gastrostomy and jejunostomy tubesComplexes of Ciprofloxacin with Metal Ions Contained in Antacid DrugsEffect of enteral feeding with ensure on oral bioavailabilities of ofloxacin and ciprofloxacinDrug Interactions with Antiulcer Agents: Considerations in the Treatment of Acid-Peptic DiseaseChemical and microbiological investigations of metal ion interaction with norfloxacinClinical Pharmacokinetics of Anti-InfectivesUrinary Tract InfectionsPharmacodynamics and pharmacokinetics of antibiotics with special reference to the fluoroquinolonesDrug interactions with fluoroquinolonesQuinolone-Cation Interactions: A ReviewNorfloxacin, the first of a new class of fluoroquinolone antimicrobials, revisitedThe Future of Pharmacy: Pharmaceutical CareUpdate on Quinolone Drug InteractionsFluoroquinolone-drug interactions: An overviewDrug-drug interactions with ciprofloxacin and other fluoroquinolonesFluoroquinolone antimicrobial agentsMiscellaneous antibacterial and antiviral drugsGastrointestinal drugs 15 July 1988Volume 109, Issue 2Page: 168-169KeywordsCathetersGuillain-Barre syndromeMusclesVentilators Issue Published: 15 July 1988 PDF DownloadLoading ...