tbuckley/cabot-search huggingface dataset:
Abstract 4146: The expression of exosomal microRNA in serum of patients with esophageal squamous cell carcinoma
Authors: Youhei Tanaka, Masayuki Watanabe, Hidenobu Kamohara, Junji Kurashige, Kousuke Mima, Hirohisa Okabe, Hideo Baba
Journal: Cancer Research (2012)

Abstract Background: Exosomes are 40 -100 nm membrane vesicles secreted by various cells such as T cells, platelets, and epithelial cells by exocytosis. Exosomes are found in blood, urine, amniotic fluid, and malignant ascites, and contain distinct subsets of microRNAs (miRs) depending upon the tumor from which they are secreted. Exosomes play a major role in cell-to-cell communication, targeting cells to transfer exosomal molecules including proteins, mRNAs, and microRNAs by an endocytosis-like pathway. Recent reports imply that miRNAs can be stably detected in circulating plasma and serum since miRNAs are packaged by exosomes to be protected from RNA degradation. We have previously reported that overexpression of miR-21 was observed in patients with esophageal squamous cell carcinoma. miR-26a is also known to be overexpressed in esophageal cancer. Objective: Aim of this study is to clarify the expression levels of miR-21 and miR-26a in exosomes from the serum of esophageal cancer patients. Patients and method: We extracted exosomes from serum of 20 esophageal cancer patients (ESCC group) and of 20 benign disease cases without inflammation (control group) by September, 2010 from October, 2009. We separated exosomes from serum, and then extracted total RNA including microRNA from exosome. Furthermore, using quantitative quantitative RT-PCR, we analyzed expression of miR-21, miR-26a where overexpression was confirmed in esophageal cancer in a past report. Results: The expression levels of miR-21 in exosomes were significantly higher in ESCC than those in control (P &amp;lt;0.001), while miR-26a expression levels in ESCC were tended to be higher than those in controls. Furthermore, we analyzed the supernatant which extracted exosomes from serum. There was almost no expression of both miRs in the supernatant after extraction of exosomes. When we compared exosomal and serum levels of miR-21, no correlation was observed between them. Conclusion: We have confirmed the elevated levels of exosomal miR-21 in the serum of patients with ESCC compared with the control. Although further analysis is needed to clarify the biological meaning of the elevated exosomal miR in the serum, the exosomal miR may become new biomarkers for ESCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4146. doi:1538-7445.AM2012-4146
The Leishman-Donovan Body in Ulcerated Surfaces: A Possible Route of its escape from the Human Body
Authors: P. Manson, G. C. Low
Journal: BMJ (1904)

I I of Dr. Luys, and the practical fact that Catbelin's urine separator can be used with the patient lying down has a dis- tinct advantage over that of Dr. Luys.Since Dr. Bickersteth's interesting paper appeared1 Luys's instrument is becoming well known in this country.Cathelin's urine separator is shaped like an English litho- trite, and has a small catheter on each side of its stem and
Epoetin Dosing and Dialysis Facility Ownership
Authors: Alan S. Kliger, Allen R. Nissenson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium
Authors: Ji Eun Lee, Jennifer L Silhavy, Maha S Zaki, Jana Schroth, Stephanie L Bielas, Sarah E Marsh, Jesus Olvera, Francesco Brancati, Miriam Iannicelli, Koji Ikegami, Andrew M Schlossman, Barry Merriman, Tania Attié-Bitach, Clare V Logan, Ian A Glass, Andrew Cluckey, Carrie M Louie, Jeong Ho Lee, Hilary R Raynes, Isabelle Rapin, Ignacio P Castroviejo, Mitsutoshi Setou, Clara Barbot, Eugen Boltshauser, Stanley F Nelson, Friedhelm Hildebrandt, Colin A Johnson, Daniel A Doherty, Enza Maria Valente, Joseph G Gleeson
Journal: Nature Genetics (2012)
The ALPI Trial: The Italian/European Experience with Adjuvant Chemotherapy in Resectable Non–Small Lung Cancer
Authors: Giorgio V. Scagliotti
Journal: Clinical Cancer Research (2005)

Abstract Postoperative treatments for lung cancer have been evaluated for more than two decades, but in the majority of the studies no significant and clinically meaningful effect on survival has been shown. In 1995, a meta-analysis of eight cisplatin-based adjuvant chemotherapy trials in 1,394 patients with non–small cell lung cancer showed a 13% reduction in the risk of death (P = 0.08). The nonstatistically significant benefit reported in the meta-analysis prompted the planning of several randomized studies of platinum-based chemotherapy. Three studies addressed the issue of adjuvant chemotherapy in all the resected stages of non–small cell lung cancer (I-IIIA): the Italian/European study Adjuvant Lung Cancer Project Italy, the International Adjuvant Lung Cancer study, and the British Big Lung Trial. In contrast to the International Adjuvant Lung Cancer, the Adjuvant Lung Cancer Project Italy and the underpowered British Big Lung Trial failed to prospectively confirm a significant role of adjuvant chemotherapy in completely resected non–small cell lung cancer. In this article, we will discuss the findings of the Adjuvant Lung Cancer Project Italy study in the context of the International Adjuvant Lung Cancer and British Big Lung Trial.
Only two Alder Hey doctors are still being investigated by GMC, say families' lawyers
Authors: Roger Dobson
Journal: BMJ (2001)

The General Medical Council has declined to comment on reports that only one of the doctors referred to it following the inquiry into the organ retention scandal at Alder Hey Children's Hospital is still facing possible disciplinary proceedings.

But lawyers acting for parents whose children had organs removed say they have been told by the council that only one of the 16 doctors implicated by the inquiry report would …
S-Nitrosothiols signal hypoxia-mimetic vascular pathology
Authors: Lisa A. Palmer, Allan Doctor, Preeti Chhabra, Mary Lynn Sheram, Victor E. Laubach, Molly Z. Karlinsey, Michael S. Forbes, Timothy Macdonald, Benjamin Gaston
Journal: Journal of Clinical Investigation (2007)

NO transfer reactions between protein and peptide cysteines have been proposed to represent regulated signaling processes. We used the pharmaceutical antioxidant N-acetylcysteine (NAC) as a bait reactant to measure NO transfer reactions in blood and to study the vascular effects of these reactions in vivo. NAC was converted to S-nitroso-N-acetylcysteine (SNOAC), decreasing erythrocytic S-nitrosothiol content, both during whole-blood deoxygenation ex vivo and during a 3-week protocol in which mice received high-dose NAC in vivo. Strikingly, the NAC-treated mice developed pulmonary arterial hypertension (PAH) that mimicked the effects of chronic hypoxia. Moreover, systemic SNOAC administration recapitulated effects of both NAC and hypoxia. eNOS-deficient mice were protected from the effects of NAC but not SNOAC, suggesting that conversion of NAC to SNOAC was necessary for the development of PAH. These data reveal an unanticipated adverse effect of chronic NAC administration and introduce a new animal model of PAH. Moreover, evidence that conversion of NAC to SNOAC during blood deoxygenation is necessary for the development of PAH in this model challenges conventional views of oxygen sensing and of NO signaling.
Enhanced oxidant stress after reperfusion is associated with persistent ST elevaation despite patent infarct-related artery in acute myocardial infarction
Authors: Yusuke Nakagawa, Yoshiyuki Kijima, Shinpei Ike, Takashi Asai, Nobuyuki Ogasawara, Megumi Kunishige, Takeshi Hata
Journal: Journal of the American College of Cardiology (2003)
Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance
Authors: William L. Holland, Joseph T. Brozinick, Li-Ping Wang, Eric D. Hawkins, Katherine M. Sargent, Yanqi Liu, Krishna Narra, Kyle L. Hoehn, Trina A. Knotts, Angela Siesky, Don H. Nelson, Sotirios K. Karathanasis, Greg K. Fontenot, Morris J. Birnbaum, Scott A. Summers
Journal: Cell Metabolism (2007)
Tactical analysis of the Barcelona counter-attack
Authors: H Sarmento, A Marques, J Martins, T Anguera, J Campaniço, J Leitão
Journal: British Journal of Sports Medicine (2011)

The purpose of this study was to observe and to characterise the tactical performance in the counter-attack (CA) of the Football Club Barcelona (FCB) in the 2009/2010 sporting season, using sequential analysis. Sixty-two sequences of CA, resulting from twelve games, were encoded using the observational instrument developed by Sarmento et al ( Medicina (Kaunas) 2010; 46 :401–7). The reliability of the data was calculated by the intra- and inter-observer agreement, and values above 0.90 for all criteria were achieved. Observational methodology was used, with special reference to the sequential analysis. For the treatment of the data SDIS-GSEQ software was used. There is a probability that the recovery of the ball possession (RBP) by disarm is followed by a dribble (Z=2.24) and, when the RBP is due an intervention of the goalkeeper, there are a tendency to the sequence to keep going by the right side of the field, in a controlled way, performing actions like the dribble (Z=2.47) and the conduction of the ball (Z=2.71). The execution of the “long pass” is related with ends of the offensive process (EOP) without efficacy, like the EOP due the rules of the game (Z=2.21). In the other hand, the results showed that have behaviours, as the dribble (Z=3.32), the crossing (z=2.82), and the intervention of the opponent without efficacy (Z=3.32), that induce the shot with the goal. The detection of behaviour patterns in the CA of the FCB proves to be particularly interesting. The study of these regularities made it possible, in a phased way, to characterize the observed offensive actions and provide important information for coaches that can be used in the training process.
A comparison of real-time, two dimensional echocardiography and cineangiography in detecting left ventricular asynergy.
Authors: J A Kisslo, D Robertson, B W Gilbert, O von Ramm, V S Behar
Journal: Circulation (1977)

Left ventricular wall motion was assessed in 105 consecutive patients both invasively, using biplane cineangiography, and noninvasively, by a real-time, phased-array, two-dimensional echocardiography system. Ventricular wall motion in five anatomic areas of the ventricle (anterolateral, posterolateral, apical, septal, and inferior) was analyzed by both methods in a double-blind manner. Two-dimensional echocardiographic images were deemed adequate for analysis in 82% of the regions (430 of 525). Fifty-five discrepancies were noted in the comparison of the remaining 430 regions. The reasons for discrepancies in interpretation between the two methods were established for 54 during retrospective review: 33 were due to echocardiography (inadequate target visualization, observer error, or tangential echo views). Fifteen were related to angiography (overlay of silhouettes or observer error), and six were due to other reasons including definition problems or spatial orientation difficulties. Both real-time, two-dimensional echocardiography and cineangiography have advantages and disadvantages. The techniques used together could provide more complete information concerning ventricular wall movement than is now currently available.
Electron Microscopic Studies of Phenotypic Modulation of Smooth Muscle Cells in Coronary Arteries of Patients With Unstable Angina Pectoris and Postangioplasty Restenosis
Authors: Ying-Hwa Chen, Yuh-Lien Chen, Shing-Jong Lin, Chia-Yu Chou, Guang-Yuan Mar, Mau-Song Chang, Shih-Pu Wang
Journal: Circulation (1997)

Proliferation and matrix protein secretion of coronary smooth muscle cells (SMCs) have been suggested as one of the mechanisms responsible for the development of postangioplasty restenosis and an alternative cause of unstable angina. Phenotypic modulation of SMCs may produce a pool of cells potentially responsive to growth stimulation that can synthesize abundant extracellular matrix. This study tested the hypothesis that phenotypic modulation of SMCs occurred during the evolution of postangioplasty restenosis and unstable angina.The SMCs of coronary atherectomy specimens from 24 patients were identified under electron microscope. Volume fractions of synthetic organelles (VFSOs) and other features related to phenotypic modulation of SMCs were measured. The results showed that the VFSO in SMCs from 5 patients with unstable angina (group 2) resembled those from 9 patients with postangioplasty restenosis (group 3; 0.42 +/- 0.13 versus 0.36 +/- 0.10; P = NS), and both were significantly higher than those from 6 patients with stable angina (group 1; 0.21 +/- 0.11). Four patients with restenosis lesions who underwent angioplasty > 6 months ago (group 4) also had a low VFSO in SMCs (0.19 +/- 0.05). This value was significantly less than those in groups 2 and 3 (P < .05) but similar to that in group 1.The coronary lesions from patients with unstable angina resembled those from patients with postangioplasty restenosis in terms of the phenotypic modulation and VFSO in SMCs. Our findings therefore suggest that after phenotypic modulation, the SMCs may become responsive to growth stimulation, with an ability to massively proliferate and synthesize abundant extracellular matrix. These processes may lead to plaque expansion and eventually to the development of unstable angina and restenosis.
A Prospective Study of Peptic Ulcer in Patients with Rheumatoid Arthritis.
Authors: E. S. Mongan
Journal: Annals of Internal Medicine (1964)

s1 April 1964A Prospective Study of Peptic Ulcer in Patients with Rheumatoid Arthritis.E. S. Mongan, M.D., E. C. Atwater, M.D., R. F. Jacox, M.D., D. R. Wieche, M.D.E. S. Mongan, M.D.Search for more papers by this author, E. C. Atwater, M.D.Search for more papers by this author, R. F. Jacox, M.D.Search for more papers by this author, D. R. Wieche, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-740_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are conflicting reports in the literature regarding the relationship of peptic ulcer to rheumatoid arthritis and corticosteroid therapy. This report deals with a prospective study of this problem. Forty-three patients with rheumatoid arthritis were classified with respect to their clinical status, before and at the time of the study. All had definite rheumatoid arthritis (according to the revised criteria of the American Rheumatism Association) and all had demonstrable rheumatoid factor in the serum.Two groups of patients were compared. The first group consisted of 25 patients with class III or IV (Steinbrocker) rheumatoid arthritis who had never taken corticosteroids... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGastric ulcer and the anti-arthritic drugs 1 April 1964Volume 60, Issue 4Page: 740-740KeywordsCorticosteroid therapyPeptic ulcersProspective studiesRheumatoid arthritis Issue Published: 1 April 1964 PDF DownloadLoading ...
Regression of Left Ventricular Hypertrophy After Nonsurgical Septal Reduction Therapy for Hypertrophic Obstructive Cardiomyopathy
Authors: Wojciech Mazur, Sherif F. Nagueh, Nasser M. Lakkis, Katherine J. Middleton, Donna Killip, Robert Roberts, William H. Spencer
Journal: Circulation (2001)

Background —Hypertrophic obstructive cardiomyopathy (HOCM) is characterized by left ventricular hypertrophy (LVH) in the absence of increased external load. Recently, nonsurgical septal reduction therapy (NSRT) with intracoronary ethanol has been introduced to treat severely symptomatic patients with outflow tract obstruction. Its long-term effects on LV mass, however, are unknown. Methods and Results —The LV size, function, and outflow tract gradient of 26 HOCM patients (53±15 years old) who underwent NSRT were assessed by echocardiography at baseline and 1 and 2 years after the procedure. LVH was evaluated by wall thickness of individual myocardial segments, planimetered myocardial area, and mass. The outflow gradient decreased from 36±6 mm Hg before NSRT to 0±3 mm Hg at 2 years ( P &lt;0.001), with patients experiencing symptomatic improvement ( P &lt;0.05). LV end-diastolic and end-systolic dimensions increased significantly at both 1 and 2 years ( P &lt;0.001). All parameters of LVH showed evidence of regression. LV mass decreased (301±78 g at baseline, 223±5 g at 1 year, and 190±58 g at 2 years; P &lt;0.01), with the 2-year reduction in mass related to infarct size and the acute reduction in outflow tract gradient ( r =0.48, P &lt;0.05 and r =0.63, P &lt;0.01, respectively). Conclusions —NSRT results in LV remodeling that is characterized by an increase in LV size and a decrease in the extent of LVH.
A NEW KNOT TYER.
Authors: A. H. CORDIER
Journal: JAMA (1893)

In doing abdominal and pelvis surgery much valuable time is often expended in tying sutures and ligatures in the recesses found in these localities. Feeling the necessity of some device to minimize the time in doing this difficult part in this class of surgery I have devised an instrument known as the "Cordier knot tyer." The working of this instrument has proved to fill in every respect my greatest expectations. Its application has a wide range and will I trust prove to be as invaluable to others as it has been serviceable to me. I will briefly mention a few of the many operations in which this instrument can be used to a good advantage in saving time and doing good execution. In a vaginal hysterectomy where the uterus is fixed and it is impossible or unadvisable to drag the organ down within easy reach and where the operator is
Abstract 2955: c-Myc suppresses DNA double-strand break repair
Authors: Zhaozhong Li, Taofeek K. Owonikoko, Shi-Yong Sun, Zhi-Qiang Xiao, Paul W. Doetsch, Fadlo R. Khuri, Walter J. Curran, Xingming Deng
Journal: Cancer Research (2012)

Abstract c-Myc is a potent oncogenic molecule that promotes tumorigenesis through the induction of genomic instability. The exact mechanism(s) involved remains to be elucidated. Here we discovered that α-ray ionizing radiation (IR)-induced double-strand DNA breaks (DSBs) promote c-Myc to form foci and to co-localize with γ-H2AX. Conditional expression of c-Myc in HO15.19 c-Myc-null cells using the Tet-Off/Tet-On inducible expression system results in downregulation of Ku DNA binding and suppressed activities of DNA-PKcs and DNA end-joining, leading to inhibition of DSB repair and enhanced chromosomal and chromatid breaks. Expression of c-Myc reduces both signal and coding joins with decreased fidelity during V(D)J recombination. Mechanistically, c-Myc directly interacts with Ku 70 protein at the N-terminus via its MBII domain. Removal of the MBII domain from c-Myc abrogates its inhibitory effects on Ku DNA binding, DNA-PKcs and DNA end-joining activities, which results in loss of c-Myc's ability to block DSB repair and V(D)J recombination. Interestingly, c-Myc directly disrupts the Ku/DNA-PKcs complex in vitro and in vivo. Thus, c-Myc suppression of DSB repair and V(D)J recombination may occur through inhibition of the non-homologous end-joining pathway, which leads to increased DNA damage, genetic instability and carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2955. doi:1538-7445.AM2012-2955
Reviews and Notes: Cardiology: Chronic Ischemic Heart Disease
Authors: Kenneth A. Ellenbogen
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 July 1996Reviews and Notes: Cardiology: Chronic Ischemic Heart DiseaseKenneth A. Ellenbogen, MDKenneth A. Ellenbogen, MDMedical College of Virginia, Richmond, VA 23298Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-1-199607010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail E Braunwald and GA Beller; eds. St. Louis: Mosby; 1995. $125.00. ISBN 1878132296. Order phone 800-426-4545.A resident or practitioner of internal medicine who is attempting to learn more about ischemic heart disease might try reading several chapters in any of the three or four excellent textbooks of cardiovascular medicine. Alternatively, this splendid atlas might be an excellent place to begin the journey.This atlas serves as a “mini-textbook,” providing an excellent overview of the diagnosis of and pharmacologic and nonpharmacologic therapy for coronary artery disease. The material is presented in a format that makes it remarkably easy to digest. ... Author, Article, and Disclosure InformationAffiliations: Medical College of Virginia, Richmond, VA 23298 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1996Volume 125, Issue 1Page: 80KeywordsCardiology and cardiovascular diseasesCardiovascular therapyClinical trialsCoronary angioplastyCoronary heart diseaseHealth careHealth information technologyIschemiaLibrariesStable coronary artery disease ePublished: 15 August 2000 Issue Published: 1 July 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...