tbuckley/cabot-search huggingface dataset:
A novel screening method for influenza patients using a newly developed non-contact screening system
Authors: Takemi Matsui, Yukiya Hakozaki, Satoshi Suzuki, Takahiro Usui, Takehito Kato, Kousuke Hasegawa, Youhei Sugiyama, Masami Sugamata, Shigeto Abe
Journal: Journal of Infection (2010)

ObjectivesIn places of mass gathering, rapid infection screening prior to definite diagnosis is vital during the epidemic season of a novel influenza. In order to assess the possibility of clinical application of a newly developed non-contact infection screening system, we conducted screening for influenza patients.Materials and methodsThe system is operated by a screening program via a linear discriminant analysis using non-contact derived variables, i.e., palmar pulse derived from a laser Doppler blood-flow meter, respiration rate determined by a 10-GHz microwave radar, and average facial temperature measured by thermography. The system was tested on 57 seasonal influenza (2008–2009) patients (35.7 °C ≤ body temperature ≤ 38.3 °C, 19–40 years) and 35 normal control subjects (35.5 °C ≤ body temperature ≤ 36.9 °C, 21–35 years) at the Japan Self-defense Forces Central Hospital.ResultsA significant linear discriminant function (p < 0.001) was determined to distinguish the influenza group from the control group (Mahalanobis D-square = 6.5, classification error rate > 10%). The system had a positive predictive value (PPV) of 93%, which is higher than the PPV value (PPV ≤ 65.4%) reported in the recent summary of studies using only thermography performed mainly in hospitals.ConclusionsThe proposed system appears promising for application in accurate screening for influenza patients at places of mass gathering.
New Drugs: Are We Being Double-Billed?
Authors: B. Robert Meyer
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Schulman et al<sup>1</sup>have provided a model that should allow us to collect useful information as we integrate an expensive new technology into the health care delivery system. As they point out in their article, this model may be adapted to the other new biotechnology products that will soon follow HA-1A (Centoxin, Centocor Inc, Malvern, Pa). One particular point that their article demonstrates quite well is how little information on the cost benefit of an expensive new therapy is available at the time of consideration for regulatory approval. Unfortunately, Schulman et al had to make a number of educated guesses about duration of intensive care unit stay and hospitalization. Much useful information to better inform these guesses could have been obtained as part of the studies performed as part of the preapproval investigation of the drug.<sup>2</sup>The pharmaceutical industry should be encouraged to incorporate this
THE EVALUATION OF THE EFFECTS OF DERIVATIVES OF RAUWOLFIA IN THE TREATMENT OF SCHIZOPHRENIA
Authors: WILLIAM MALAMUD, WALTER E. BARTON, ALICE M. FLEMING, PETER MCK. MIDDLETON, TOBIAS T. FRIEDMAN, MAXWELL J. SCHLEIFER
Journal: American Journal of Psychiatry (1957)

Six derivatives of Rauwolfia were used in the treatment of a series of chronic schizophrenics, and the therapeutic results were compared among themselves and with results obtained through the use of placebos. The patients were selected with consideration of adequate matching and were evaluated psychiatrically before treatment. The course of their illness was systematically studied during the administration of the treatment and for a period of 6 months to one year after termination of the treatment. The comparison of the effects of both drugs and placebos was in terms of changes in specific behavior items, as well as the general evaluation of their clinical status and adjustment in the hospital or outside as judged by the hospital personnel. The results obtained justify the following conclusions: 1. The drugs differed from one another in terms of the degree of beneficial effect on the general condition of the patients, some being more effective than others; and all the drugs were more effective than the placebos. However, the spread was not too wide and some improvements were observed even in the patients to whom placebos were administered. 2. The effects of the drugs showed a trend toward specificity in that each drug tended to have a greater effect upon certain behavior items than was obtained with other drugs. 3. In the case of some of the drugs, the beneficial effect produced during treatment was maintained after termination and through the follow-up period, whereas in others this effect was not maintained.
High Expression of Cyclin E Increases the Risk for Breast Cancer Death by 2-3 Fold in Node Negative Breast Cancer Patients.
Authors: C. Lundgren, M. Holmqvist, L. Holmberg, L. Holmberg, C. Blomqvist, M. Fjällskog
Journal: Cancer Research (2009)

Abstract Background: A large proportion of women with lymph node negative breast cancer treated with chemotherapy do not benefit from such treatment. Several studies have suggested that proliferation markers can identify patients at increased risk for recurrence. However, current international guidelines do not recommend proliferation markers for clinical use due to lack of well-powered studies and standardization of methodology. We wanted to investigate the prognostic value of cyclin E1 in a large population-based study on node negative breast cancer patients.Study Design: In a population-based, case-control study, 190 women who died from breast cancer were defined as cases and 190 women alive at the time for the corresponding case's death as controls. Inclusion criteria were tumor size ≤ 50 mm, no lymph node metastases and no adjuvant chemotherapy. The study was designed to detect an odds ratio (OR) of 2.5 with a power of 90% at a significance level of 0.05. Tumor tissue was immunostained for cyclin E1 with a commercial antibody. Statistical analyses were performed for 200 (cyclin E 200) and 500 cells (cyclin E 500) counted, respectively.Results: Cyclin E1 was highly correlated to histologic grade, Ki-67 and cyclins A/B (rs= 0.5-0.6; p&amp;lt;0.001) and inversely correlated to hormone receptors (rs=-0.2--0.3; p&amp;lt;0.001). There was a statistically significant association between cyclin E1 and breast cancer death both in uni- and multivariate (adjusted for tumor size and age) analyses with OR 2.6 -2.7 for cyclin E 200 and OR 2.1-1.9 for cyclin E 500.Conclusions: We found that cyclin E1 is a prognostic factor for breast cancer death in a population-based node negative patient cohort. Patients with tumors expressing high levels of cyclin E have a 2-3 fold increased risk for breast cancer death. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3033.
Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Authors: Gabriel G. Malouf, Xiaoping Su, Hui Yao, Jianjun Gao, Liangwen Xiong, Qiuming He, Eva Compérat, Jérôme Couturier, Vincent Molinié, Bernard Escudier, Philippe Camparo, Denaha J. Doss, Erika J. Thompson, David Khayat, Christopher G. Wood, Willie Yu, Bin T. Teh, John Weinstein, Nizar M. Tannir
Journal: Clinical Cancer Research (2014)

Abstract Purpose: MITF/TFE translocation renal cell carcinoma (TRCC) is a rare subtype of kidney cancer. Its incidence and the genome-wide characterization of its genetic origin have not been fully elucidated. Experimental Design: We performed RNA and exome sequencing on an exploratory set of TRCC (n = 7), and validated our findings using The Cancer Genome Atlas (TCGA) clear-cell RCC (ccRCC) dataset (n = 460). Results: Using the TCGA dataset, we identified seven TRCC (1.5%) cases and determined their genomic profile. We discovered three novel partners of MITF/TFE (LUC7L3, KHSRP, and KHDRBS2) that are involved in RNA splicing. TRCC displayed a unique gene expression signature as compared with other RCC types, and showed activation of MITF, the transforming growth factor β1 and the PI3K complex targets. Genes differentially spliced between TRCC and other RCC types were enriched for MITF and ID2 targets. Exome sequencing of TRCC revealed a distinct mutational spectrum as compared with ccRCC, with frequent mutations in chromatin-remodeling genes (six of eight cases, three of which were from the TCGA). In two cases, we identified mutations in INO80D, an ATP-dependent chromatin-remodeling gene, previously shown to control the amplitude of the S phase. Knockdown of INO80D decreased cell proliferation in a novel cell line bearing LUC7L3–TFE3 translocation. Conclusions: This genome-wide study defines the incidence of TRCC within a ccRCC-directed project and expands the genomic spectrum of TRCC by identifying novel MITF/TFE partners involved in RNA splicing and frequent mutations in chromatin-remodeling genes. Clin Cancer Res; 20(15); 4129–40. ©2014 AACR.
Randomised trial of effects of interferon-α on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis
Authors: S Nishiguchi, T Kuroki, S Nakatani, H Morimoto, T Takeda, S Nakajima, S Shiomi, S Seki, K Kobayashi, S Otani
Journal: The Lancet (1995)
Closed extensor tendon rupture and distal radial fracture with use of a gymnast's wrist support.
Authors: P R Stuart, P J Briggs
Journal: British Journal of Sports Medicine (1993)

We report a case of delayed closed rupture of the tendon of extensor indicis proprius in a skeletally immature individual. This occurred following a minor greenstick fracture during use of a gymnast's wrist-finger support. To our knowledge this unusual complication has not been described previously.
Comparison of Effects of Angiotensin and Norepinephrine on Pulmonary Circulation, Systemic Arteries and Veins, and Systemic Vascular Capacity in the Dog
Authors: JOHN C. ROSE, PETER A. KOT, JAY N. COHN, EDWARD D. FREIS, GERALD E. ECKERT
Journal: Circulation (1962)

In dog experiments, angiotensin II and norepinephrine were compared in regard to some components of the generalized pressor response each of these agents produces. It was found that angiotensin II has no direct effect on pulmonary blood vessels, in contrast to the pulmonary vasoconstrictor effect of norepinephrine. Angiotensin II appeared to have no effects on veins or the systemic vascular capacity, while norepinephrine was a potent venoconstrictor with, therefore, a marked ability to reduce the systemic vascular capacity.
Poor adherence is the main reason for loss of CCyR and imatinib failure for chronic myeloid leukemia patients on long-term therapy
Authors: Amr R. Ibrahim, Lina Eliasson, Jane F. Apperley, Dragana Milojkovic, Marco Bua, Richard Szydlo, Francois-Xavier Mahon, Kasia Kozlowski, Christos Paliompeis, Letizia Foroni, Jamshid S. Khorashad, Alex Bazeos, Mathieu Molimard, Alistair Reid, Katayoun Rezvani, Gareth Gerrard, John Goldman, David Marin
Journal: Blood (2011)
Abstract LB-61: Comparative study of different diagnostic techniques (AI, MLPA, FISH) in breast cancer patients with 1q25.3 alterations
Authors: Emilia Wiechec, Tina Kjeldsen, Jens Overgaard, Eigil Kjeldsen, Lise Lotte Hansen
Journal: Cancer Research (2010)

Abstract Background: Breast cancer is the most frequently diagnosed malignancy among women and is the leading cause of cancer related death worldwide. Molecular genetic studies have revealed many subgroups of breast cancer within which the genomic alterations affecting chromosome arm 1q are considered to be an early event in breast carcinogenesis and are correlated with favorable prognosis for the patients. We have found a high percentage of concordance between the AI and MLPA assays pointing towards gain of the 1q25.3 region in breast cancer. Aims: Our main objective was to compare the sensitivity and specificity of AI and synthetic probe-based MLPA with other cytogenetic method (FISH) in breast cancer patients with or without previously confirmed alterations within 1q25.3. Methods: FISH was performed on formalin-fixed paraffin-embedded tumor material in order to verify previous findings and assess the level of genetic alterations of 1q25.3 in breast cancer. The 1q25.3 test and 1p35 reference probes labeled with different fluorochromes were utilized for analysis. Results: A total of 70 nuclei from each breast cancer case were examined and scored for the percentage of 1q25.3 alterations. The non-tumorigenic nuclei obtained from healthy individuals served as adequate cut-off for the 1q25.3-specific changes. The overall FISH results are consistent with results obtained from previous analysis in the majority of analysed cases. Furthermore, FISH resolved the level of 1q25.3 alterations in few cases that were uncertain by AI and MLPA analysis. Conclusion: This study shows that both AI and MLPA assays are able to map regions of copy number changes in the cancer genome and are in concordance with molecular cytogenetics. These three techniques proved to be an efficient tool for diagnosis of 1q25.3 alterations, however, confusing results in AI and MLPA analysis might be obtained while using non-microdissected tumor DNA as a template. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-61.
Doctor who received 1.2m from patient's estate is struck off
Authors: C. Dyer
Journal: BMJ (2011)

A psychiatrist who accepted £1.2m (€1.4m; $1.9m) from the estate of a vulnerable patient has been struck off by the General Medical Council for behaviour that “would appal other medical practitioners and shake the confidence of the public in the profession.”

Peter Rowan, 62, a private practitioner in Harley Street, central London, prescribed “excessive amounts” of benzodiazepines to Patricia May, a former actor who had had anorexia for more than 30 years when she died, aged 66, in 2003 after a fall at her home.

A GMC fitness to practise panel found that …
Cardiovascular and antiarrhythmic effects of aprindine (AC 1802) during partial occlusion of a coronary artery in the pig
Authors: P. D. VERDOUW, W. J. REMME, P. G. HUGENHOLTZ
Journal: Cardiovascular Research (1977)

The effect of intravenously administered aprindine (AC1802) as a prophylactic agent against ventricular arrhythmias was studied in pigs. During the first 30 min of ischaemia 5 of the 22 untreated animals died because of ventricular fibrillation against 1 of the 23 animals pretreated with aprindine (P=0.09). Ventricular tachycardias were observed in 10 untreated animals and in none of the aprindine group (P=0.0002). The incidence of other arrhythmias was significantly less in the aprindine group compared with the untreated group (P less than 0.02).
Serum Ferritin Levels and Iron Deficiency
Authors: William H. Crosby
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Dr Kasper<sup>1</sup>states that "the serum ferritin level may be raised by inflammations and infections even in the presence of iron deficiency." Her meaning is not clear. The level may be normal in iron deficiency, but it is never raised above the normal range.
Effect of ST segment measurement point on performance of standard and heart rate-adjusted ST segment criteria for the identification of coronary artery disease.
Authors: P M Okin, G Bergman, P Kligfield
Journal: Circulation (1991)

Recent reports critical of the performance of heart rate-adjusted indexes of ST depression during exercise electrocardiography have used J-point rather than ST segment measurements. However, no standard exists for the optimal time after the J-point at which to measure ST segment deviation.To assess the effect of ST segment measurement position on performance of standard exercise electrocardiographic criteria, the delta ST segment/heart rate (delta ST/HR) index, and the ST segment/heart rate (ST/HR) slope for the detection of coronary artery disease, the exercise electrocardiograms of 50 clinically normal subjects and 80 patients with known or likely coronary disease were analyzed using ST depression measured at both the J-point and at 60 msec after the J-point (J + 60). A positive exercise electrocardiogram by standard criteria, defined as 0.1 mV or more of additional horizontal or downsloping ST depression at end exercise, had a specificity of 96% when ST depression was measured at either the J-point or J + 60. There was no difference in sensitivity of standard electrocardiographic criteria at J + 60 and J point (both 59%, p = NS). However, at matched specificity of 96%, the delta ST/HR index and ST/HR slope calculated using ST depression at J + 60 were significantly more sensitive (90% and 93%) than when calculated using J-point depression (64% and 61%, each p less than 0.001). Comparison of areas under respective receiver operating characteristic curves confirmed the superior performance of J + 60 as opposed to J-point measurements for both the delta ST/HR index (0.98 versus 0.89, p = 0.006) and the ST/HR slope (0.96 versus 0.87, p = 0.007) and also demonstrated modestly improved overall test performance for standard electrocardiographic criteria using J + 60 measurements (0.88 versus 0.82, p = 0.001).Use of J-point measurements significantly degrades performance of heart rate-adjusted indexes of ST depression but has less effect on standard criteria.
Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation
Authors: Agnieszka A. Wendorff, Ute Koch, F. Thomas Wunderlich, Silvia Wirth, Christelle Dubey, Jens C. Brüning, H. Robson MacDonald, Freddy Radtke
Journal: Immunity (2010)
Serco pulls out of out-of-hours care in Cornwall
Authors: J. Wise
Journal: BMJ (2013)

The private contractor Serco has reached a “mutual agreement” to end its GP out-of-hours contract in Cornwall 17 months early. The embattled company, which this week has been forced to hand over contracts for electronic tagging in the criminal justice system, also announced that it is to pull out of running Braintree Hospital in Essex after a review of its healthcare operations.

Serco has been extensively criticised over its out-of-hours service, including in reports from the Care Quality Commission and the National Audit Office.1 2 These reports were prompted by whistleblowers’ claims that Serco’s service was understaffed and that it was altering data to ensure it was meeting its targets.

In July the parliamentary public accounts select committee published a damning report on the …
Is Screening for Cancer Worth While? Results from a Well-woman Clinic for Cancer Detection
Authors: J. B. Davey, W. P. Greening, J. A. McKinna
Journal: BMJ (1970)

1,768 women were screened for breast and cervical cancer in the year May 1968 to April 1969. Clinical examination followed the completion of a simple questionary. Investigations included thermography and mammography of the breast and cytology of the cervical and vaginal smears. Breast cancer was detected in 15 patients (0·85% or 8·5 per 1,000) and none was aware of any abnormality though 13 of the tumours were clinically palpable. Carcinoma in situ of the cervix was found in a further eight (0·45% or 4·5 per 1,000).
A Case of Vaginal Atresia and Absence of Menstruation Cured by the Use of Tangle-Tents
Authors: W. Murray
Journal: BMJ (1868)

YOUPArL-5 dot can be made for the removal of the disee yet they a nt forth.restoration of the lip.The natural maipm of the lipis retained.The only cicatrix left is the single one in the middle line.The result- ing mouth shortly becomes an excelent one, perfectly usefl, and not
A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14
Authors: Abbas M Solouki, Virginie J M Verhoeven, Cornelia M van Duijn, Annemieke J M H Verkerk, M Kamran Ikram, Pirro G Hysi, Dominiek D G Despriet, Leonieke M van Koolwijk, Lintje Ho, Wishal D Ramdas, Monika Czudowska, Robert W A M Kuijpers, Najaf Amin, Maksim Struchalin, Yurii S Aulchenko, Gabriel van Rij, Frans C C Riemslag, Terri L Young, David A Mackey, Timothy D Spector, Theo G M F Gorgels, Jacqueline J M Willemse-Assink, Aaron Isaacs, Rogier Kramer, Sigrid M A Swagemakers, Arthur A B Bergen, Andy A L J van Oosterhout, Ben A Oostra, Fernando Rivadeneira, André G Uitterlinden, Albert Hofman, Paulus T V M de Jong, Christopher J Hammond, Johannes R Vingerling, Caroline C W Klaver
Journal: Nature Genetics (2010)
Peripheral Lymphatico-Venous Anastomoses
Authors: P. RUBEN KOEHLER, BURTON SCHAFFER
Journal: Circulation (1967)

Two cases of peripheral lymphatico-venous anastomoses are reported. These communications, which generally are only visualized in the presence of obstruction of the lymphatics, are of practical importance because of the potential danger of relative rapid transfer of oily contrast material into the pulmonary circulation. The existence and importance of these communications are discussed.
Thrombocytopenia and Carcinoma
Authors: G. N. Brodie, D. Bliss, B. G. Firkin
Journal: BMJ (1970)

The cases of two patients suffering from carcinoma of the lung and severe thrombocytopenia are described. The thrombocytopenia was probably due to an immune mechanism and not to marrow replacement by carcinoma or consumption coagulopathy. It is suggested that patients in the older age group presenting with thrombocytopenia may have occult carcinoma.
Erythrocyte-mediated delivery of phenylalanine ammonia lyase for the treatment of phenylketonuria in BTBR-Pahenu2 mice
Authors: Luigia Rossi, Francesca Pierigè, Claudia Carducci, Claudia Gabucci, Tiziana Pascucci, Barbara Canonico, Sean M. Bell, Paul A. Fitzpatrick, Vincenzo Leuzzi, Mauro Magnani
Journal: Journal of Controlled Release (2014)

Phenylketonuria (PKU) is an autosomal recessive genetic disease caused by defects in the phenylalanine hydroxylase gene. Preclinical and clinical investigations suggest that phenylalanine ammonia lyase (PAL) could be an effective alternative for the treatment of PKU. The aim of this study is to investigate if erythrocytes loaded with PAL may act as a safe delivery system able to overcome bioavailability issues and to provide, in vivo, a therapeutically relevant concentration of enzyme. Murine erythrocytes were loaded with recombinant PAL from Anabaena variabilis (rAvPAL) and their ability to perform as bioreactors was assessed in vivo in adult BTBR-Pahenu2 mice, the genetic murine model of PKU. Three groups of mice were treated with a single i.v. injection of rAvPAL-RBCs at three different doses to select the most appropriate one for assessment of efficacy. Repeated administrations at 9–10 day-intervals of the selected dose for 10 weeks showed that the therapeutic effect was persistent and not affected by the generation of antibodies induced by the recombinant enzyme. This therapeutic approach deserves further in vivo evaluation either as a potential option for the treatment of PKU patients or as a possible model for the substitutive enzymatic treatment of other inherited metabolic disorders.
Effect on training on myocardial oxygen supply/demand balance.
Authors: R J Barnard, R MacAlpin, A A Kattus, G D Buckberg
Journal: Circulation (1977)

In five well-trained and five sedentary control subjects potential subendocardial blood supply was estimated from the diastolic pressure time index (DPTI) and myocardial oxygen demands from the tension time index (TII) during a progressive near-maximal treadmill test. DPTI/TTi was used to assess the effects of training on myocardial oxygen supply/demand balance. DPTI/TTI was significantly higher in trained subjects at rest and comparable workloads. At 6.4 km/hr, 18% grade (maximum for the controls), TTI was significantly lower (4300 +/- 76 vs 4495 +/- 99 mm Hg-sec/min) and DPTI significantly higher (2534 +/- 86 vs 2295 +/- 91 mm Hg-sec/min) in the trained subjects; DPTI/TTI was significantly higher (0.59 +/- .02 vs 0.50 vs .03). At near-maximal heart rates both groups achieved the same supply/demand balance (0.50); however, the trained subjects were working at higher workloads. We conclude that endurance conditioning increases work capacity, reduces myocardial O2 demands, increases potential O2 supply and improves the supply/demand balance at any given submaximal workload which reduces the risk of ischemia.