tbuckley/cabot-search huggingface dataset:
GPs to get 1% pay rise for 2015-16
Authors: A. Rimmer
Journal: BMJ (2015)

The UK government has accepted the recommendation of the Review Body on Doctors’ and Dentists’ Remuneration (DDRB) to increase GPs’ pay by 1% for 2015-16.

The government said that this rise equalled a 1.16% increase to the GP contract for 2015-16, once the expenses of running a practice were taken into account. “This compares to last year’s contract uplift of …
Some observations on propranolol on platelet aggregation and release
Authors: Rafael Leon, Cheryl Y. Tiarks, Liberto Pechet
Journal: American Journal of Hematology (1978)

Platelet function was investigated in four normal volunteers, one patient with a mild form of von Willebrand disease, and one with a thrombocytopathy, all taking propranolol. No effect on platelet function attributable to this drug could be demonstrated in any of these subjects. It is suggested that propranolol administered in conventional doses does not impair platelet hemostatic function.
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients
Authors: Tetsushi Sadakata, Miwa Washida, Yoshimi Iwayama, Satoshi Shoji, Yumi Sato, Takeshi Ohkura, Ritsuko Katoh-Semba, Mizuho Nakajima, Yukiko Sekine, Mika Tanaka, Kazuhiko Nakamura, Yasuhide Iwata, Kenji J. Tsuchiya, Norio Mori, Sevilla D. Detera-Wadleigh, Hironobu Ichikawa, Shigeyoshi Itohara, Takeo Yoshikawa, Teiichi Furuichi
Journal: Journal of Clinical Investigation (2007)

Autism, characterized by profound impairment in social interactions and communicative skills, is the most common neurodevelopmental disorder, and its underlying molecular mechanisms remain unknown. Ca(2+)-dependent activator protein for secretion 2 (CADPS2; also known as CAPS2) mediates the exocytosis of dense-core vesicles, and the human CADPS2 is located within the autism susceptibility locus 1 on chromosome 7q. Here we show that Cadps2-knockout mice not only have impaired brain-derived neurotrophic factor release but also show autistic-like cellular and behavioral phenotypes. Moreover, we found an aberrant alternatively spliced CADPS2 mRNA that lacks exon 3 in some autistic patients. Exon 3 was shown to encode the dynactin 1-binding domain and affect axonal CADPS2 protein distribution. Our results suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autism susceptibility.
Progressive proliferative glomerulonephritis in a patient with rheumatoid arthritis treated with D-penicillamine.
Authors: A J Williams, J N Fordham, C G Barnes, F J Goodwin
Journal: Annals of the Rheumatic Diseases (1986)

A 49 year old man with rheumatoid arthritis developed a proliferative glomerulonephritis with progressive renal impairment during treatment with D-penicillamine. His renal function continued to deteriorate after the drug was stopped but improved after treatment with corticosteroids and azathioprine.
Abstract 317: 1q32.1 and 16q21 genomic alterations implicate KIF14/MDM4/PIK3C2ß and CDH11 as independent prognostic markers of relapse in localized Ewing Family of Tumors
Authors: Fernanda R.R Ayala, Isabela Werneck da Cunha, Maisa Yoshimoto, Maria Zielenska, Jeremy Andrew Squire, Fernando Augusto Soares
Journal: Cancer Research (2011)

Abstract EWS-ETS genetic fusion appears to be the initiating mechanism behind Ewing Family of Tumors (EFT) pathogenesis; however, progression of the disease is dependent on additional genetic alterations. Using the Progenetix database, we identified mainly alterations at 1q, and at 16q, as the most recurrent genetic alterations in EFT without consistency as markers of relapse. Clinic features of a large genotype cohort of 135 patients with EFT were retrospectively reviewed from A.C. Camargo hospital records. Tissue microarrays (TMA) were built for multi-color interphase fluorescent in situ hybridization (iFISH) analysis of aberrations at 1q32.1 (KIF14/MDM4/PIK3C2ß) and 16q21 (CDH11) using in-house probes. Gains were defined by the presence of more than three hybridization signals per interphase nucleus with simultaneous intact centrosome signal occurring in more than 5% of tumor nuclei. Losses were indicated by one target signal with the intact centrosome signals in more than 30% of nuclei. The frequencies of gene copy number alterations (CNA) were compared with clinical parameters and follow-ups. Statistical analyses were performed by SPSS program. A p-value of less than 0.05 was considered significant. CNA analysis showed gains at 1q32.1 in 15/128 (11.7%) cases, while abnormalities at 16q21 were seen in 24/118 (20.3%) patients, split into two groups. One group of patients, 11/118 (9.3%), showed only hemizygous deletion, whereas, the other group with 13/118 (11%) patients showed gain. A significant association between 1q32.1 gains and 16q21 losses (p=0.029) was detected, but not a significant clinical synergism when interacting at the same patient. Univariate analyses showed gains at 16q21 (p=0.029) or at 1q32.1 (p=0.005) associated with tumor relapse in the localized disease subgroup. Disease-free survival curves represented these gained regions as unfavorable outcome parameters (p&amp;lt;0.05) for EFT patients. The multivariate model confirmed 1q32.1 or 16q21 gains as independent prognostic markers for relapse. Hence, copy number gains at 1q32.1 and 16q21 constitute valuable markers of relapse in localized EFT. Genomic alterations of the critical genes in these chromosomal regions probably activate key downstream target genes of distinct pathways, which thus lead to an intricate molecular mechanism for EFT growth and aggressiveness. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 317. doi:10.1158/1538-7445.AM2011-317
Trimodality Treatment of Malignant Pleural Mesothelioma
Authors: Hasan Fevzi Batirel, Muzaffer Metintas, Hale Basak Caglar, Bedrettin Yildizeli, Tunc Lacin, Korkut Bostanci, Asli Gul Akgul, Serdar Evman, Mustafa Yuksel
Journal: Journal of Thoracic Oncology (2008)
Importance of complete cutaneous examination for the detection of malignant melanoma
Authors: Darrell S. Rigel, Robert J. Friedman, Alfred W. Kopf, Robert Weltman, Phillip G. Prioleau, Bijan Safai, Mark G. Lebwohl, Yehuda Eliezri, Douglas P. Torre, Robert T. Binford, Vincent A. Cipollaro, Laszlo Biro, Donald Cbarbonneau, Athana Mosettis
Journal: Journal of the American Academy of Dermatology (1986)
Pandemic influenza 1918.
Authors: N R Grist
Journal: BMJ (1979)

We debated the exact meaning of our instructions ; but the general cut through the discussion by saying characteristically I've got to carry the can. He promptly invited Hugh Cairns and Howard Florey to visit him again to resume discussion on the issue they had raised. Harold Bensted and I were invited to be present as witnesses to the conversation. Harold and I agreed to listen without speaking, which we did. I recall the general's exact words, which I think he had memorised because I recall his pacing to and fro reciting words to himself before the meeting. Gentlemen, said the general, you warned me of the political importance of the advice I should give on this matter. I accepted your warning. Consequently, I referred the issue for a political decision. I asked that this should go right to the top. We have had our answer. It is written in green ink?you know, I take it, what that means. I am now clear about my advice. It is that penicillin should be used to treat gonorrhoea among the assault troops in Algiers. The interview ended in polite exchanges and, so far as I know, there were no political repercussions. My own view is that Harold Bensted's military and political judgment was right, and that Leo Poole's way of handling the event proved that he was a wise, shrewd, and honest soldier capable of carrying any can that was handed to him.
GAMMA GLOBULIN PRODUCTION IN GERMFREE RATS AFTER BACTERIAL CONTAMINATION
Authors: Bengt E. Gustafsson, Carl-Bertil Laurell
Journal: The Journal of Experimental Medicine (1959)

The earlier observed pronounced hypogammaglobulinemia in germfree rats of different ages has been confirmed. Using an immunologic technique the concentration of immunologic gamma globulins were found to vary between 10 and 15 per cent of the values observed in ordinary rats. Upon contamination of germfree rats with the normal microbial flora a pronounced lag phase was noted before the gamma globulin level became normal. This lag phase was most pronounced in growing rats. Newborn rats seem to start gamma globulin production more rapidly than older germfree rats. The response with regard to gamma globulin production on contamination of germfree rats with different types of bacterial cells through the natural routes is not identical.
Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infection
Authors: I. Schulte, T. Hitziger, S. Giugliano, J. Timm, H. Gold, F.M. Heinemann, Y. Khudyakov, M. Strasser, C. König, E. Castermans, J.Y. Mok, W.J.E. van Esch, A. Bertoletti, T.N. Schumacher, M. Roggendorf
Journal: Journal of Hepatology (2010)
Dietary Fat and Postmenopausal Breast Cancer
Authors: L. H. Kushi, T. A. Sellers, J. D. Potter, C. L. Nelson, R. G. Munger, S. A. Kaye, A. R. Folsom
Journal: JNCI Journal of the National Cancer Institute (1992)

Background: Although the results of animal studies and cross-cultural comparisons generally support a role for dietary fat in the etiology of breast cancer, results of analytic epidemiology studies are equivocal. Purpose: The association between dietary fat and subsequent breast cancer was examined in a cohort of 34 388 postmenopausal women from Iowa. Methods: Dietary habits were assessed by a food-frequency questionnaire mailed in January 1986. Through December 31, 1989, 459 incident cases of breast cancer occurred in this cohort. Proportional hazards regression was used to examine the dietary fat-breast cancer association while adjusting for potential confounders. The effects on this association of four analytic approaches to adjustment for energy intake were also considered. Results : After adjustment for known determinants of breast cancer, a modest positive association of total fat intake with risk of breast cancer was seen. Polyunsaturated fat intake was also positively associated with breast cancer (relative risk from lowest to highest intake, 1.0, 1.25, 1.31, and 1.49; P for trend =.052). Different approaches to adjustment for energy intake, however, provided different impressions of the dietary fat-breast cancer association. One method, involving categorization of crude fat intake and inclusion of total energy intake in regression analysis, gave relative risk estimates from low to high fat intake of 1.0, 1.17, 1.25, and 1.38 ( P for trend = .18). Another method, based on categorization of fat intake residuals in which the variation in fat due to total energy intake was removed, gave corresponding estimates of 1.0, 1.24, 1.30, and 1.16 ( P for trend = .29). The former suggests increasing breast cancer risk with increasing fat intake; the latter suggests no association. Conclusions: These results are consistent with other cohort studies that have shown a weak association or no association between dietary fat and breast cancer. They are also consistent with studies suggesting that fat intake is a determinant of breast cancer, particularly after accounting for inaccuracies in dietary assessment. The effects of different energy-adjustment methods may account in part for the varying interpretations of four previous cohort studies of dietary fat and breast cancer. Implications: Further work is needed to clarify not only the nature of the dietary fat-breast cancer association, but also the impact of different analytic methods used in the investigation of diet-disease associations. [J Natl Cancer Inst 84: 1092–1099, 1992]
Comparison of Risk Prediction Using the CKD-EPI Equation and the MDRD Study Equation for Estimated Glomerular Filtration Rate
Authors: Kunihiro Matsushita, Bakhtawar K. Mahmoodi, Mark Woodward, Jonathan R. Emberson, Tazeen H. Jafar, Sun Ha Jee, Kevan R. Polkinghorne, Anoop Shankar, David H. Smith, Marcello Tonelli, David G. Warnock, Chi-Pang Wen, Josef Coresh, Ron T. Gansevoort, Brenda R. Hemmelgarn, Andrew S. Levey, for the Chronic Kidney Disease Prognosis Consortium
Journal: JAMA (2012)

The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation more accurately estimates glomerular filtration rate (GFR) than the Modification of Diet in Renal Disease (MDRD) Study equation using the same variables, especially at higher GFR, but definitive evidence of its risk implications in diverse settings is lacking.
Twice-Daily Humulin Ultralente Insulin Decreases Morning Fasting Hyperglycemia
Authors: Nnacy B Johnson, Kathleen K Kronz, Naomi S Fineberg, Michael P Golden
Journal: Diabetes Care (1992)

OBJECTIVE To test whether a two-injection regimen of HUL/R would improve FBG and metabolic control in pediatric IDDM patients with a dawn rise in FBG compared with our standard twice-daily therapy, HL/R. RESEARCH DESIGN AND METHODS Seventy-seven patients with fasting hyperglycemia (prebreakfast mean FBG ≥ 8.3 mM (150 mg/dl) during the preceding 2 wk) were evaluated with twice-weekly midsleep (0230–0330) FBG for 2 wk. Forty-seven patients (61%) had a mean dawn rise between midsleep and prebreakfast of ≥ 2.8 mM (50 mg/dl). Patients continued on HL/R for an additional 4 wk, after which 31 patients were then randomized into a double-blind 12-wk trial of either HUL/R (n = 14) or HL/R (n = 17) administered before breakfast and the evening meal. Midsleep FBG was obtained twice weekly with weekly insulin adjustment as needed to optimize glycemic control. FBG was monitored and verified with memory glucometers (Glucometer M). HbA1c levels were measured at the time of physician visits at 0, 6, and 12 wk. RESULTS Prebreakfast FBG was lower in the HUL/R-treated patients (10.6 ± 0.6 vs. 12.6 ± 0.6 mM [191 ± 6.4 vs. 227 ± 11.2 mg/dl], P &amp;lt; 0.02). The dawn rise was diminished in the HUL/R patients (0.5 ± 0.5 vs. 2.6 ± 0.7 mM [9 ± 8.3 vs. 46 ± 11.7 mg/dl], P &amp;lt; 0.02). FBG at lunch, dinner, bedtime, and midsleep were similar in both groups, and HbA1c did not differ between groups or change significantly in either group during the 12-wk trial. Insulin dose, percentage R, day-night dosage split, and episodes of hypoglycemia (FBG &amp;lt; 3.3 mM [60 mg/dl]) were similar in both groups. CONCLUSIONS A 12-wk trial of twice-daily HUL/R improved fasting glycemia in pediatric patients with a dawn rise but did not improve metabolic control as measured by HbA1c.
Excessive alpha-fetoprotein concentrations in hepatocellular carcinoma.
Authors: A H Amery, W C Alston, J Kohn, W F White
Journal: BMJ (1977)

Excessive alpha-fetoprotein concentrations in hepatocellular carcinomaWe describe a patient with hepatocellular carcinoma, whose serum concentration of ac-fetoprotein exceeded 4 800 000 ,ug/l and produced an extra band on protein electrophoresis. Case reportA boy aged 16 was admitted to Frimley Park Hospital, Surrey, on 18 February 1976 complaining of severe right shoulder pain and abdominal distension of about two weeks' duration.He had a massively enlarged liver with considerable abdominal distension.Laboratory investigations gave the following results (normal ranges in parentheses): haemoglobin 12-1 g/dl (13-18 g/dl); total protein 76 g/l (60-74 g/l); albumin 43 g/l (36-47 g/l); total bilirubin 43 ,umol/l (2-5 mg/100 ml) (2-19 Ismol/l (0-12-1.1 mg/ 100 ml)); alkaline phosphatase 1866 U/I (80-300 U/1); aspartate amino- transferase 476 U!l (0-40 U/l); y-glutamyltransferase 792 U/l (0-45 U/1).-g,ii* (b) ,.e, 4tt. ~~~A 1 |c A,AfJ;4A t,' t._
Occupational Exposure to Crystalline Silica Dust in the United States, 1988–2003
Authors: Abdiaziz Yassin, Francis Yebesi, Rex Tingle
Journal: Environmental Health Perspectives (2004)

The purposes of this study were a) to summarize measurements of airborne (respirable) crystalline silica dust exposure levels among U.S. workers, b) to provide an update of the 1990 Stewart and Rice report on airborne silica exposure levels in high-risk industries and occupations with data for the time period 1988-2003, c) to estimate the number of workers potentially exposed to silica in industries that the Occupational Safety and Health Administration (OSHA) inspected for high exposure levels, and d) to conduct time trend analyses on airborne silica dust exposure levels for time-weighted average (TWA) measurements. Compliance inspection data that were taken from the OSHA Integrated Management Information System (IMIS) for 1988-2003 (n = 7,209) were used to measure the airborne crystalline silica dust exposure levels among U.S. workers. A second-order autoregressive model was applied to assess the change in the mean silica exposure measurements over time. The overall geometric mean of silica exposure levels for 8-hr personal TWA samples collected during programmed inspections was 0.077 mg/m3, well above the applicable American Conference of Governmental Industrial Hygienists threshold limit value of 0.05 mg/m3. Surgical appliances supplies industry [Standard Industrial Classification (SIC) 3842] had the lowest geometric mean silica exposure level of 0.017 mg/m3, compared with the highest level, 0.166 mg/m3, for the metal valves and pipe fitting industry (SIC 3494), for an 8-hr TWA measurement. Although a downward trend in the airborne silica exposure levels was observed during 1988-2003, the results showed that 3.6% of the sampled workers were exposed above the OSHA-calculated permissible exposure limit.
High-Dose Vitamin D Supplementation
Authors: Bess Dawson-Hughes, Susan S. Harris
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Unusual Speech Disorder following Encephalitis Lethargica: Its Interpretation and Therapeutic Management
Authors: ALFRED GORDON
Journal: Annals of Internal Medicine (1933)

Article1 January 1933An Unusual Speech Disorder following Encephalitis Lethargica: Its Interpretation and Therapeutic ManagementALFRED GORDON, A.M., M.D., F.A.C.P.ALFRED GORDON, A.M., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-7-895 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn reviewing the various sequelae of encephalitis lethargica reported by observers one is surprised at the multiplicity of phenomena in the different spheres of human organization. The sensory system in general, the special sensorium, the motor-system at its various levels, the vegetative sphere, the sympathetic nervous system, finally the psychic functions in general, including the affective status, may all isolatedly or conjointly become involved. Data are continuously accumulating. Many varieties of tic-like movements and analogous hyperkinetic manifestations have been observed and described. Some of them are relatively frequent, such as oculogyric crises; other manifestations are more or less rare, such...References1 DUBOIS C: Un curieux tic de la langue d'origine vraisemblablement postencéphalitique, Rev. Neurol., 1929, i, 40-45. Google Scholar2 BING R: Zur Frage des "Parkinsonismus" als Folgezustand der Encephalitis lethargica, Schweiz. med. Wchnschr., 1921, ii, 4-12. BING, R.: Über lokale Muskelspasmen und Tics, nebst Bemerkungen zur Revision des Begriffes der "psychogenie", Schweiz. med. Wchnschr., 1925, vi, 293-1000. Google Scholar3 CHRISTIN E: Note sur un cas de contracture de la langue postencéphalitique, Rev. Neurol., 1922, xxix, 1184. Google Scholar4 STERLING W: Palilalie et le symptôme "linguo-salivaire" dans le parkinsonisme encéphalitique, Rev. Neurol., 1924, xxxi, 205-220. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALFRED GORDON, A.M., M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaRead, and patients exhibited, at the January meeting of the Philadelphia Neurological Society, 1932.Received for publication, January 18, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliography 1 January 1933Volume 6, Issue 7Page: 895-900KeywordsEncephalitisSympathetic nervous system ePublished: 1 December 2008 Issue Published: 1 January 1933 PDF downloadLoading ...
Drugs To Prevent Colon Cancer Show Promise, But Hurdles Remain for Chemoprevention
Authors: R. Tuma
Journal: JNCI Journal of the National Cancer Institute (2008)

A low-dose combination of sulindac and difluoromethylornithine (DFMO) reduced the risk of recurrent colorectal adenomas by 70% and high-risk adenomas by 92% compared with placebo in a randomized controlled trial, researchers reported in April at the annual meeting of the American Association for Cancer Research (AACR). Also, 5-year follow-up data from the Adenoma Prevention with Celecoxib (APC) trial showed that individuals who took celecoxib during the trial continued to be at lower risk of developing adenomas 2 years after they stopped taking the drug, compared with participants who took a placebo. These results could fundamentally change chemoprevention, experts agree. The magnitude of the benefi t in the sulindac – DFMO trial was larger than expected for any type of chemoprevention. (As designed, the trial would have been deemed a success if the combination had reduced the risk by 50%.) And the trial is the fi rst to show that a combination of chemoprevention drugs is effective and safe. The APC data show that the use of nonsteroidal antiinfl ammatory drugs, specifi cally a cyclooxygenase-2 (COX-2) inhibitor, reduces the development of adenomas instead of just masking the presence of lesions. “The fi eld of [nonsteroidal antiinfl ammatory drugs] and COX-2 inhibitors — and in some people’s minds, the entire concept of chemoprevention — was in ashes when the COX-2 selective inhibitor [toxicity] reports came out in 2005,” said Scott Lippman, M.D. , professor and chair of thoracic and head and neck medical oncology at the University of Texas M. D. Anderson Cancer Center in Houston. Those reports, showing that celecoxib and rofecoxib (Vioxx) increased the risk of cardiovascular disease and death, garnered so much attention that when researchers reported the initial effi cacy data from the APC trial in 2006, few noticed. “I think what we are seeing now in these two very important trials is that the phoenix is rising,” Lippman said.