tbuckley/cabot-search huggingface dataset:
Benefit of immunosuppression for severe Takayasu's arteritis and coincident primary biliary cirrhosis
Authors: E Feist
Journal: Annals of the Rheumatic Diseases (2004)

Takayasu’s arteritis and primary biliary cirrhosis (PBC) are two unrelated autoimmune diseases without a so far reported coincidence, probably because they occur at different ages.1,2 As a systemic vasculitis, Takayasu’s arteritis affects predominantly the aorta and its branches in female patients before the age of 40 years. The clinical manifestations are variable and severe anatomical lesions can lead to life threatening ischaemia. We report an unusual case, where, after the initial diagnosis of a coincident severe Takayasu’s arteritis with PBC, subsequent immunosuppressive treatment led to a striking clinical improvement of vasculitic symptoms in an elderly woman.

A 70 year old woman was referred to our hospital with generalised weakness and disseminated painful cutaneous, erythematous nodules on the extensor sites of both lower legs. A rheumatic disorder had been suspected since 1960 because of remittent nausea, attacks of fulminant headaches, and an erythema nodosum. Clinical examination showed a diminished bilateral radial and an absent carotid pulse as well as hypotensive blood pressure on both arms (85/60 and 90/60 mm …
Recovery after Depressive Attack of 30 Years' Duration
Authors: G. M. Woddis
Journal: BMJ (1957)

CONSTITUTIONAL VIRILISM MEDICBAOURNabsolute bar to conception: indeed, the most hirsute patient in the series had five children.On the other hand, it does appear likely that there is a definite tendency to infertility in a certain proportion of the patients.Enlargement of the clitoris had not been looked for systematically, but it has been observed on only two occasions, and is regarded as distinctly uncommon.It would also have been of interest to make an assessment of the degree of muscularity and subcutaneous fat development.A further aspect that merits attention is that of the person- ality structure of these individuials.Barr and Bertram (1949) reported the discovery of special chromatin bodies in the nerve cells of cats, found only in female animals.These observations were extended to human skin by Moore, Graham.and Barr (1953) and later to other tissues, and it has become customary to think of the relationship as an all-or-none phenomenon.However, it is noteworthy that Davidson and Robertson Smith (1954) noted a considerable variation in the ease with which the characteristic "drumsticks" could be found in polymorpho- nuclear neutrophil leucocytes from female patients, the inci- dence ranging from 1 :6 to I : 98.Some preliminary observa- tions have been made on the incidence of these chromatin bodies in hirsute women, and, although the numbers as yet are few, a possible difference between hirsute and non- hirsute subjects may exist, a lesser incidence being encoun- tered in the former.This is conceivably a further expres- sion of a general tendency towards masculinity. SummaryAn association has been demonstrated between hirsuties and two other masculine characters in women-namely, increased shoulder width and raised 17-ketosteroid excre- tion.A significant correlation has also been demon- strated between hirsuties and oligomenorrhoea.The term constitutional virilism is a convenient one to describe the composite syndrome.The condition appears to be genetically determined, and the results obtained suggest that the inheritance is multifactorial.
Government confirms that food policy agency is moving to Whitehall
Authors: J. Carlowe
Journal: BMJ (2010)

The Food Standards Agency in England is to be carved up so that nutritional policy will now fall to the Department of Health and responsibility for food labelling will go to the Department for Environment, Food and Rural Affairs.

The agency will retain responsibility for policy and enforcement in food safety and its role in Scotland, Wales, and Northern Ireland remains unchanged.

In announcing the reorganisation on 20 July the government has quashed rumours that the Food Standards Agency was to be axed in its entirety.

The decision to transfer nutritional policy, including front of pack nutrition labelling, to the Department of Health is in line with …
Benefit of Active Compression-Decompression Cardiopulmonary Resuscitation as a Prehospital Advanced Cardiac Life Support
Authors: Patrick Plaisance, Fre´de´ric Adnet, Eric Vicaut, Brigitte Hennequin, Philippe Magne, Christophe Prudhomme, Yves Lambert, Jean-Paul Cantineau, Catherine Le´opold, Catherine Ferracci, Mirella Gizzi, Didier Payen
Journal: Circulation (1997)

Background We compared short-term prognosis of active compression-decompression (ACD) and standard (STD) cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrests. Methods and Results We randomized advanced cardiac life support (ACLS) with ACD ACLS CPR on odd days and STD ACLS CPR on even days. We measured the rates of return of spontaneous circulation (ROSC), survival at 1 hour (H 1 ), at 24 hours (H 24 ), and at 1 month (D 30 ); hospital discharge (HD); neurological outcome; and complications. Mean times from collapse to basic cardiac life support CPR was 9 minutes and from collapse to ACLS CPR was 21 minutes. Compared with the STD ACLS patients (n=258), ACD ACLS patients (n=254) had higher survival rates (ROSC, 44.9% versus 29.8%, P =.0004; H 1 , 36.6% versus 24.8%, P =.003; H 24 , 26% versus 13.6%, P =.002; HD without neurological impairment, 5.5% versus 1.9%, P =.03) and a trend for improvement in neurological outcome at D 30 (Glasgow-Pittsburgh Outcome Categories=1.6±0.8 versus 2.3±1.1, P =.09). Sternal dislodgments (2.9% versus 0.4%, P =.03) and hemoptysis (5.4% versus 1.3%, P =.01) were more frequent in the ACD ACLS group. Conclusions Despite long time intervals, ACD significantly improved short-term survival rates in out-of-hospital cardiac arrests compared with STD CPR.
The Effect of Noradrenaline on the Calcium Uptake of the Sarcoplasmic Reticulum
Authors: E. A. Shinebourne, M. L. Hess, R. J. White, J. Hamer
Journal: Cardiovascular Research (1969)

Journal Article The Effect of Noradrenaline on the Calcium Uptake of the Sarcoplasmic Reticulum Get access E. A. Shinebourne, E. A. Shinebourne From the Cardiac Department, St. Bartholomew's Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar M. L. Hess, M. L. Hess * From the Cardiac Department, St. Bartholomew's Hospital, London * Present address: University of Pittsburgh, Pa., U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. J. White, R. J. White From the Cardiac Department, St. Bartholomew's Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Hamer J. Hamer From the Cardiac Department, St. Bartholomew's Hospital, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 3, Issue 2, April 1969, Pages 113–117, https://doi.org/10.1093/cvr/3.2.113 Published: 01 April 1969 Article history Received: 27 June 1968 Published: 01 April 1969
Stereotactic Ablative Radiotherapy (SART) of Lung Lesion in Oligometastatic Patients: the Importance of High Doses Delivery
Authors: V. Scotti, I.F. Furfaro, D. Scartoni, L. Paoletti, M. Loi, S. Russo, S. Pallotta, B. Agresti, P. Bastiani, L. Livi
Journal: Annals of Oncology (2015)
Sustaining Change in Medical Education
Authors: Paul F. Griner
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Case of the Missing Vault: A ???Cold??? Bone Lesion Following Electrical Burn
Authors: G G CAMERON, N D GREYSON, W A CUMMING, G R LLOYD, J R BIRCH
Journal: Clinical Nuclear Medicine (1981)

Osteonecrosis of the skull produced by an electrical burn presented as a dramatic “cold” bone lesion on an MDP bone scan, despite normal skull radiographs. Four months later the skull radiograph showed marked bone resorption, and the three-phase bone scan confirmed healing and new osteoblastic activity. The pathophysiology of high-voltage injuries is outlined.
Exercise Increases Adiponectin Levels and Insulin Sensitivity in Humans
Authors: Adamandia D. Kriketos, Seng Khee Gan, Ann M. Poynten, Stuart M. Furler, Donald J. Chisholm, Lesley V. Campbell
Journal: Diabetes Care (2004)

Adiponectin is an abundant circulating adipocytokine with anti-inflammatory properties (1) linked to cardiovascular disease, type 2 diabetes, and obesity (2–5). Numerous reports (3–5), including the present one, confirm plasma adiponectin levels to be inversely related to insulin resistance. Longer term, a rise in adiponectin has been shown to occur in response to weight loss and glitazone therapy, but not after chronic exercise training. However, understanding of the shorter-term regulation of adiponectin in particular remains unclear. As an extension to a previously reported exercise intervention in sedentary males by our group (6), we have now examined the effects of this training intervention on adiponectin levels in overweight males. We demonstrate that the short-term exercise training increased circulating adiponectin levels with accompanied improved insulin sensitivity.

Twenty-six overweight males participated in an exercise program, as previously described (6). Full data were available on 19 subjects who completed the entire program. At …
Antitumour necrosis factor-? chimeric antibody (infliximab) inhibits activation of skin-homing CD4+ and CD8+ T lymphocytes and impairs dendritic cell function
Authors: C. Bedini, F. Nasorri, G. Girolomoni, O. de Pità, A. Cavani
Journal: British Journal of Dermatology (2007)

Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and altered differentiation of keratinocytes in reply to cytokines such as interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha, provided by infiltrating CD4+ and CD8+ T cells and natural killer cells. Infliximab is a chimeric monoclonal antibody that neutralizes both soluble and membrane-bound TNF-alpha, and that may give a long-term disease remission.To determine the in vitro effects of infliximab on CD4+ and CD8+ T cells derived from lesional skin, and on dendritic cells (DCs).Psoriatic T-cell lines were isolated from lesional skin of four patients with psoriasis and assayed for their proliferation, cytokine release and susceptibility to apoptotic stimuli in the presence of graded (1-100 microg mL(-1)) concentrations of infliximab. DCs were differentiated in the presence of infliximab from peripheral blood monocytes. Phenotype was assessed by fluorescence-activated cell sorting and antigen-presenting capacity in functional assays.In vitro activation of psoriatic as well as antigen (nickel)-specific skin-homing T cells was strongly and dose-dependently impaired by infliximab, in terms both of proliferation and of IFN-gamma release. Despite the significant reduction of IFN-gamma secretion, infliximab only marginally affected the release of interleukin (IL)-10 by skin T cells, thus determining a reduction of the IFN-gamma/IL-10 ratio at the site of inflammation. The effects were maximal when T-cell activation occurred in the absence of costimulation, or when T cells were activated by immature compared with mature DCs. In addition, skin-homing CD8+ T cells were more prominently affected by infliximab compared with CD4+ T lymphocytes, both in terms of inhibition of activation and in their susceptibility to apoptosis. Finally, infliximab directly affected the differentiation of monocyte-derived DCs, by inhibiting the expression of CD1a and CD86, and strongly impaired the antigen-presenting capacity of immature and, to a lesser extent, mature DCs.Infliximab directly affects psoriatic T cells and impairs the antigen-presenting capacity of DCs. These effects may help to explain the long-term disease remission obtained with the drug.
Adverse Outpatient Drug Events — A Problem and an Opportunity
Authors: William M. Tierney
Journal: New England Journal of Medicine (2003)

On the day I was asked to write this editorial, my 80-year-old father had a nearly fatal adverse drug event. His physicians had attributed the nonspecific symptoms to his Parkinson's disease and had increased his dose of levodopa–carbidopa. His physical and cognitive function continued to worsen, until hallucinations, chorioform movements, and blepharospasm characteristic of levodopa–carbidopa toxicity developed and he became bedridden. The drug was stopped, and his condition improved dramatically over the ensuing 48 hours; he became ambulatory and regained his base-line mental status. This incident had many of the typical features of adverse drug events. It involved an elderly . . .
Progress in Treating Cystic Fibrosis Means That Many Patients May Now Reach Midlife and Beyond
Authors: Bridget M. Kuehn
Journal: JAMA (2014)

In the not-too-distant past, parents were counseled that children with cystic fibrosis were unlikely to live past their teenage years. But a new estimate of patients’ life spans suggests that many can now expect to live into their 40s and beyond.
Total serum <scp>I</scp>g<scp>E</scp> level influences oral food challenge tests for <scp>I</scp>g<scp>E</scp>‐mediated food allergies
Authors: K. Horimukai, K. Hayashi, Y. Tsumura, I. Nomura, M. Narita, Y. Ohya, H. Saito, K. Matsumoto
Journal: Allergy (2014)

Probability curves predicting oral food challenge test (OFC) results based on specific IgE levels are widely used to prevent serious allergic reactions. Although several confounding factors are known to affect probability curves, the main factors that affect OFC outcomes are currently unclear. We hypothesized that an increased total IgE level would reduce allergic reactivity. Medical records of 337 and 266 patients who underwent OFCs for 3.5 g boiled hen's egg white and 3.1 ml raw cow's milk, respectively, were examined retrospectively. We subdivided the patients into three groups based on total IgE levels and age by percentile (<25th, 25-75th, and >75th percentiles), and logistic regression analyses were performed on each group. Patients with higher total IgE levels were significantly less responsive. In addition, age did not significantly affect the OFC results. Therefore, total IgE levels should be taken into account when predicting OFC results based on food-specific IgE levels.
Ejection timing as a major determinant of left ventricular relaxation rate in isolated perfused canine heart.
Authors: M Hori, M Inoue, M Kitakaze, K Tsujioka, Y Ishida, M Fukunami, S Nakajima, A Kitabatake, H Abe
Journal: Circulation Research (1984)

In the present study, we attempted to test the hypothesis that ejection timing rather than peak left ventricular pressure is a primary determinant of ventricular relaxation rate. In cross-circulated isolated canine hearts instantaneous left ventricular volume was controlled by a servo-pump system. To eliminate the effects of end-systolic and end-diastolic volumes and ejection velocity on left ventricular relaxation rate, these parameters were clamped, and only the ejection timing (onset and end of ejection) was altered, keeping the duration of ejection unchanged. Left ventricular relaxation rate was assessed by time constants of left ventricular pressure decline during the isovolumic relaxation phase calculated by both a semilogarithmic method, assuming that the asymptote is zero, and a best exponential fitting method. In 25 runs, a pair of contractions with ejection timings which differed by 53.1 +/- 2.1 (SE) msec were imposed, while end-systolic and end-diastolic left ventricular volumes and ejection duration were unchanged. All pairs of contractions demonstrated early ejection resulted in significantly (P less than 0.001) slowed relaxation as indicated by a prolongation of the time constants of isovolumic left ventricular pressure decay (delta 4.2 +/- 0.7, sec and delta 15.4 +/- 2.1 msec by semilogarithmic plot and the best exponential fit respectively), although peak left ventricular pressures (104.6 +/- 2.4 mm Hg) were even lower than those (116.6 +/- 2.8 mm Hg) in contractions with later ejection timing. Furthermore, in seven experiments, the heart was allowed to eject at five different timings; onset and end of ejection were progressively delayed in steps of 20 or 30 msec.(ABSTRACT TRUNCATED AT 250 WORDS)
Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.
Authors: E J Goetzl,, J M Woods, R R Gorman
Journal: Journal of Clinical Investigation (1977)

A human platelet lipoxygenase-generated product of arachidonic acid, identified by thin-layer chromatographic and mass spectrometric properties as 12-L-hydroxy-5,8,10,14-eicosatertraenoic acid (HETE), was selectively chemotactic in vitro for human polymorphonuclear leukocytes (PMN), as compared to mononuclear leukocytes, with a preference for eosinophils. Preincubation of PMN with partially-purified HETE at peak chemotactic concentrations of 8-24 mug/ml reduced their random and chemotactic migration and stimulated the activity of their hexose monophosphate shunt; minimally chemotactic concentrations of 0.03-1 mug/ml enhanced PMN random migration without influencing other functions. HETE may thus be capable of preferentially attracting eosinophils to foci of tissue reaction associated with platelet activation.
GPs are being paid more for doing less, MPs are told
Authors: Andrew Cole
Journal: BMJ (2006)

Family doctors are getting paid more for doing less as a result of the new GP contract, the House of Commons select committee on health was told last week.

Bonnie Sibbald, deputy director of the National Primary Research and Development Centre at Manchester University, said her unit had conducted a national survey of 1000 GPs that showed that on average they were now earning £15 000 a year more and were working four hours less each week.

Asked whether she thought this was justified, Professor Sibbald replied, “No.”

But she added that ongoing research, involving a panel of 45 practices, indicated …
Isolation of Autonomously Growing Dog Mammary Tumor Cell Lines Cultured in Medium Supplemented With Serum Treated To Inactivate Growth Factors
Authors: B. van der Burg, A. J. P. van Selm-Miltenburg, P. van Maurik, G. R. Rutteman, W. Misdorp, S. W. de Laat, E. J. J. van Zoelen
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Isolation of Autonomously Growing Dog Mammary Tumor Cell Lines Cultured in Medium Supplemented With Serum Treated To Inactivate Growth Factors Get access Bart van der Burg, Bart van der Burg * Hubrecht Laboratory, Netherlands Institute for Developmental BiologyUtrecht, The Netherlands *Correspondence to: Dr. Bart van der Burg, Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. Search for other works by this author on: Oxford Academic PubMed Google Scholar Adrie J. P. van Selm-Miltenburg, Adrie J. P. van Selm-Miltenburg Hubrecht Laboratory, Netherlands Institute for Developmental BiologyUtrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Pim van Maurik, Pim van Maurik Hubrecht Laboratory, Netherlands Institute for Developmental BiologyUtrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerard R. Rutteman, Gerard R. Rutteman Small Animal Clinic, Faculty of Veterinary Medicine, University of UtrechtUtrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Wim Misdorp, Wim Misdorp Small Animal Clinic, Faculty of Veterinary Medicine, University of UtrechtUtrecht, The NetherlandsNetherlands Cancer InstituteAmsterdam, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Siegfried W. de Laat, Siegfried W. de Laat Hubrecht Laboratory, Netherlands Institute for Developmental BiologyUtrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Everardus J. J. van Zoelen Everardus J. J. van Zoelen Hubrecht Laboratory, Netherlands Institute for Developmental BiologyUtrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 20, 18 October 1989, Pages 1545–1551, https://doi.org/10.1093/jnci/81.20.1545 Published: 18 October 1989 Article history Received: 24 April 1989 Revision received: 24 July 1989 Accepted: 28 July 1989 Published: 18 October 1989
Hidden Perforating Veins
Authors: J. M. Pegum
Journal: BMJ (1970)

DBIATISOUNALincompetence never exhibit the distressing symptoms or show the gross lesions that are found in patients with incompetence of perforators just above the ankle.You state that it takes less than an hour to examine both legs by thermography and that this method can be extremely accurate, but you have omitted to state how effective is this method in detecting all incompetent perforators.Mr. K. D. Patil and colleagues (p.195) correctly detected 79 incompetent perforators in between 62 and 66 limbs, and
Stud Gun Injuries
Authors: William H. Schmid
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The stud gun, an industrial tool at least as lethal as a firearm of comparable caliber and charge, fires a pin or threaded stud into concrete or steel. Accurate statistics of injuries inflicted by these tools are unavailable; the only data produced by a query to the National Institute for Occupational Safety and Health was a table showing 56 such accidents in the state of New York during the years 1966 to 1970. Stud gun injuries were reported frequently in the early '60s,<sup>1-4</sup>and in 1970, Spitz and Wilhelm<sup>5</sup>published a review and experimental study of the tool's lethality. In 1971, the Occupational Safety and Health Standards Act (29CFR, 1910. 243) regulated the use of explosive-actuated fastening tools to prevent the types of accidents that had occurred. The following cases have come to my attention. A 50-year-old welder was fatally shot with a stud gun