tbuckley/cabot-search huggingface dataset:
A criss-cross heart with concordant atrioventriculo-arterial connections. Report of a case.
Authors: K Sato, S Ohara, I Tsukaguchi, K Yasui, T Nakada, M Tamai, Y Kobayashi, T Kozuka
Journal: Circulation (1978)

A distinctive angiographic appearance is described in a case of "criss-cross" heart with concordant atrioventriculo-arterial connections. The atrial situs was normal, and the morphological right ventricle was superior to the left ventricle, and the ventricular septum was horizontal in position. Both ventricleswere connected by a small ventricular septal defect. The aorta was situated anteriorly and to the right of the pulmonary artery. Although the cardiac segment was the apparent [S,L,D] type, the heart had conconrdant atrioventriculo-arterial connections. The ventricular rotation of the solitus heart about the longitudinal and the anteroposterior axis affected the atrioventricular flows, the plane of the ventricular septum, the inflow and outflow tracts of the ventricles, the interrelationship of the great arteries, and the course of the left coronary artery. Using the recent definition of criss-cross heart, we classified the heart as solitus-concordant (l-rotated) -normal.
Association Between Newborn Birth Weight and Prenatal Care for Cocaine Users-Reply
Authors: Andrew D. Racine
Journal: JAMA (1994)

In Reply.  —Dr Morfesis highlights an important methodological issue: the problem of self-selection and the bias it may introduce into the results of a retrospective analysis. We share his concern and deliberately drew attention to the problem in the introduction and the Comment sections of our study.  The general question that his communication poses is whether the existence of this type of bias invalidates any conclusions derived from retrospective analysis. We do not believe this to be the case. All studies concerning the effect of prenatal care on birth outcome suffer, to greater or lesser degree, from self-selection bias. The only definitive method of eliminating this source of bias is to conduct an intervention in which women are randomly assigned to receive varying amounts of prenatal care, an unethical proposition.  As in many fields of scientific inquiry, the existence of potential sources of bias does not, in and of itself,
Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: Role for NO and Kupffer cell-derived oxidants
Authors: Hisashi Taniai, Ian N. Hines, Sulaiman Bharwani, Ronald E. Maloney, Yuji Nimura, Bifeng Gao, Sonia C. Flores, Joe M. McCord, Matthew B. Grisham, Tak Yee Aw
Journal: Hepatology (2004)

Ischemia/reperfusion (I/R) is an important problem in liver resection and transplantation that is associated with hepatocellular dysfunction and injury. This study was designed to investigate whether a difference in hepatocyte susceptibility occurs in the periportal (PP) and/or perivenous (PV) zones in response to hypoxia/reoxygenation (H/R), and to delineate the mechanisms underlying this susceptibility. H/R was induced in an in situ perfused mouse liver model with deoxygenated Krebs-Henseleit buffer followed by oxygenated buffer. Selective destruction of PP or PV sites was achieved by digitonin perfusion into the portal or inferior vena cava, and was confirmed by histological evaluations and zone-specific enzymes. Hepatocellular injury was assessed by alanine aminotransferase (ALT) release. In whole liver, H/R significantly increased perfusate ALT. H/R of PP-enriched zones caused ALT release that was similar to that of whole liver (80 + 10 vs. 70 + 12 U/mg protein), consistent with significant PP hepatocyte injury. Minimal ALT release occurred in PV zones (10 + 5 U/mg protein). Administration of N-acetyl L-cysteine or a chimeric superoxide dismutase (SOD)-SOD2/3, a genetically engineered SOD-abrogated ALT release in H/R-perfused PP zones, implicating a role for superoxide (O(2) (-)). This elevated ALT release was attenuated by gadolinium chloride pretreatment, indicating that Kupffer cells are the O(2) (-) source. Enzymatic inhibition of cellular nitric oxide synthase (NOS) or genetic depletion of endothelial nitric oxide synthase (eNOS) aggravated hypoxia injury while exogenous NO and inducible nitric oxide synthase (iNOS) deficiency abolished reoxygenation injury. In conclusion, PP hepatocytes are more vulnerable to H/R; this injury is mediated directly or indirectly by Kupffer cell derived O(2) (-) and is limited by eNOS-derived NO.
Resolution of Acquired Factor X Deficiency and Amyloidosis with Melphalan and Prednisone Therapy
Authors: John K Camoriano, P. R. Greipp, G. K. Bayer, E. J W Bowie
Journal: New England Journal of Medicine (1987)

ALTHOUGH primary amyloidosis is refractory to most treatments, there have been some reports of limited but definite clinical improvements in patients treated with melphalan and prednisone.1 2 3 4 5 6 The improvements have included resolution of the nephrotic syndrome,7 a decrease in the size of the spleen and liver, normalization of the levels of hepatic enzymes,6 a decline in light-chain synthesis,3 and a reduction of amyloid in sequential liver-biopsy specimens.6 Since the first report (in 1962) of acquired factor X deficiency in amyloidosis,8 more than 30 cases have been described.9 10 11 12 13 14 15 16 Patients with this disorder may have life-threatening bleeding that is usually difficult to manage . . .
CANCER SUPERVENTION IN SKIN-DISEASES: CLINICAL, MICROSCOPIC AND THERAPEUTIC CONSIDERATIONS
Authors: JOSEPH JORDAN ELLER, NELSON PAUL ANDERSON
Journal: British Journal of Dermatology (1930)

Journal Article CANCER SUPERVENTION IN SKIN‐DISEASES: CLINICAL, MICROSCOPIC AND THERAPEUTIC CONSIDERATIONS Get access JOSEPH JORDAN ELLER, M.D., JOSEPH JORDAN ELLER, M.D. New York Search for other works by this author on: Oxford Academic Google Scholar NELSON PAUL ANDERSON, M.D. NELSON PAUL ANDERSON, M.D. New York Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 42, Issue 6, 1 June 1930, Pages 263–289, https://doi.org/10.1111/j.1365-2133.1930.tb09414.x Published: 01 June 1930
Reply to Homayoun Zargar, Rafael F. Coelho and Jihad H. Kaouk's Letter to the Editor re: R. Houston Thompson, Tom Atwell, Grant Schmit, et al. Comparison of Partial Nephrectomy and Percutaneous Ablation for cT1 Renal Masses. Eur Urol 2015;67:252–9
Authors: R. Houston Thompson, Tom Atwell, Grant Schmit, Christine M. Lohse, A. Nicholas Kurup, Adam Weisbrod, Sarah P. Psutka, Suzanne B. Stewart, Matthew R. Callstrom, John C. Cheville, Stephen A. Boorjian, Bradley C. Leibovich
Journal: European Urology (2014)
Abdominal Pain and Mass
Authors: Trisha L. Marshall, Kristin C. Turza, Stephen L. Cook, Philip W. Smith
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Echocardiographic Evaluation of Left Ventricular Function
Authors: Richard L. Popp
Journal: New England Journal of Medicine (1977)

Echocardiography may make substantial contributions to the definition and measurement of left ventricular function in man. Several unique features of this method make it attractive, but less obvious limitations have been recognized recently. Echocardiography has been applied to measurement of the extent of left ventricular function only within the past few years, so that it is not surprising that its application is still very much in a developmental phase. Although echocardiography is in daily clinical use for a great many cardiac conditions, most experts classify measurement of left ventricular function by this means as investigational.Measurements of cardiac dimensions and . . .
Utility of Influenza Vaccination for Oncology Patients
Authors: Daniel A. Pollyea, Janice M.Y. Brown, Sandra J. Horning
Journal: Journal of Clinical Oncology (2010)

Every fall and winter, patients with cancer and their families ask oncologists whether they should be vaccinated for influenza. This season, with escalating concerns regarding the novel H1N1 influenza virus and its recently approved vaccine, this question has become more frequent and increasingly urgent. The purpose of this article is to review evidence related to the ability of patients with cancer to mount protective immunological responses to influenza vaccination. The literature on immunogenicity in pediatric and adult patients, those with solid tumors and hematologic malignancies, untreated and actively treated patients, and patients receiving biologic agents is summarized and reviewed. In addition, we report on potential strategies to improve the efficacy of influenza vaccination in patients with cancer, such as the timing of vaccination, use of more than a one-shot series, increasing the antigen dose, and the use of adjuvant therapies. We conclude that there is evidence that patients with cancer receiving chemotherapy are able to respond to influenza vaccination, and because this intervention is safe, inexpensive, and widely available, vaccination for seasonal influenza and the novel H1N1 strain is indicated.
A2-03: The combination of total tumor volume, number of positive lymph node stations on PET, gender, performance status and radiation dose is the best predictor for survival in patients with inoperable NSCLC, stage I-IIIB, treated with (chemo)radiation
Authors: Cary Dehing-Oberije, Dirk De Ruysscher, Hiska van der Weide, Monique Hochstenbag, Wiel Geraedts, Cordula Pitz, Jean Simons, Gerben Bootsma, Harald Steck, Philippe Lambin
Journal: Journal of Thoracic Oncology (2007)
Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells
Authors: Le Wang, Hongbin Fan, Zhi-Yong Zhang, Ai-Ju Lou, Guo-Xian Pei, Shan Jiang, Tian-Wang Mu, Jun-Jun Qin, Si-Yuan Chen, Dan Jin
Journal: Biomaterials (2010)
TCT-469 Association Of Activated Clotting Times During Percutaneous Coronary Intervention and Clinical Outcomes
Authors: Naveen Rajpurohit, Mayank K Mittal, Adam Stys, Arashk Motei, Mandeep Singh, Rajiv Gulati, Ryan Lennon, Charanjit Rihal, Shahyar M Gharacholou
Journal: Journal of the American College of Cardiology (2014)
Atypical lymphocytes with a multilobated nucleus from a patient with tsutsugamushi disease (scrub typhus) in Japan
Authors: Hiromichi Iwasaki, Takanori Ueda, Michihiko Uchida, Toru Nakamura, Nobuhiro Takada, Fumihiko Mahara
Journal: American Journal of Hematology (1991)

Abstract A case of tsutsugamushi disease (scrub typhus) with atypical lymphocytes with a multilobated nucleus is reported. Although this type of atypical lymphocyte has been reported in patients with viral infections such as adult T‐cell leukemia, infectious mononucleosis, human immunodeficiency virus (HIV) infection, this is the first reported case of atypical lymphocyte with a multilobated nucleus in a patient with rickettsial infection. This type of atypical lymphocyte seems to exist in a broad spectrum of infectious diseases.
Implementing an Electronic Medical Record System: Successes, Failures, Lessons
Authors: Prentiss Taylor
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Behavioral game theory: Plausible formal models that predict accurately
Authors: Colin F. Camerer
Journal: Behavioral and Brain Sciences (2003)

Many weaknesses of game theory are cured by new models that embody simple cognitive principles, while maintaining the formalism and generality that makes game theory useful. Social preference models can generate team reasoning by combining reciprocation and correlated equilibrium. Models of limited iterated thinking explain data better than equilibrium models do; and they self-repair problems of implausibility and multiplicity of equilibria.
On the Death of Dr Robert Levet
Authors: C. Packer
Journal: BMJ (2010)

One of Samuel Johnson’s greatest poems was an elegy for a physician and friend who for many decades cared for the London poor with grace and simplicity. Robert Levet was, according to Johnson’s biographer James Boswell, “an obscure practitioner of physic amongst the lower people” who collected minimal fees but had such an extensive practice that he walked daily on his rounds “from Houndsditch to Marylebone.”

Johnson had a passionate sympathy for the poor, and called the silent and tireless Levet “a very useful and very blameless man.” When Levet died, Johnson was moved to write a poem that the critic W Jackson Bate has praised for its “deep, dignified, and accurate feeling directly engaged with real and daily things.” …
"Anirrit" in the Treatment of Epilepsy
Authors: P. K. Robinson
Journal: BMJ (1956)

speculation, for the pulmonary plasmocytosis might just be part of a general tissue infiltration; but this is rather un- likely, since, of all the tissues examined, only marrow, spleen, and lungs were involved by plasma cells.A further com- plication is the propensity of the lungs for retaining and extracting cells from the blood stream (Osogoe, 1950; Vaughn, 1953), which may have influenced the final histo- logical composition.
Systematic Review: Comparing Routine and Selective Invasive Strategies for the Acute Coronary Syndrome
Authors: Rehan Qayyum, M. Rizwan Khalid, Jurga Adomaityte, Stylianos P. Papadakos, Frank C. Messineo
Journal: Annals of Internal Medicine (2008)

Background: Patients with non–ST-segment elevation acute coronary syndrome (ACS) are managed with either a routine invasive strategy, in which all patients receive coronary angiography, or a selective invasive strategy, in which only patients with refractory or inducible ischemia receive coronary angiography. Purpose: To evaluate whether a routine invasive strategy improves cardiovascular outcomes more than a selective invasive strategy in patients with non–ST-segment elevation ACS. Data Sources: English-language publications in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1966 to 18 September 2007. Study Selection: Two investigators independently reviewed searches and selected trials that compared death or myocardial infarction outcomes among adults with non–ST-segment elevation ACS by randomly assigning patients to either a routine invasive strategy or a selective invasive strategy. Data Extraction: Three investigators independently abstracted data from trial reports by using standardized forms. Data Synthesis: 10 trials with a total of 10 648 patients (mean age, 62 years; 71% male; median follow-up, 16.5 months) were found. Trial participants had typical symptoms of unstable angina and frequently had a positive electrocardiogram or marker evidence of myocardial ischemia. Of the 5330 participants assigned to the routine invasive strategy group, 847 had the composite outcome of death or nonfatal myocardial infarction, compared with 928 of 5318 participants assigned to the selective invasive strategy group (relative risk, 0.90 [95% CI, 0.74 to 1.08]). Four hundred thirty-eight patients in the routine invasive strategy group and 463 in the selective invasive strategy group died (relative risk, 0.95 [CI, 0.80 to 1.14]). Four hundred ninety and 569 nonfatal myocardial infarctions, respectively, occurred in the 2 groups (relative risk, 0.86 [CI, 0.68 to 1.08]). Limitations: Methodology, protocols, and outcome definitions differed substantially among the trials. The lower bound of the CI for the pooled results did not rule out the superiority of the routine invasive strategy. Conclusion: Available trial evidence is heterogeneous and insufficient for comparing routine and selective invasive strategies. Therefore, in patients with non–ST-segment elevation ACS a routine invasive strategy cannot be proven to reduce deaths or nonfatal myocardial infarction.
Memory, Alcohol, and The Law
Authors: Ralph S. Ryback
Journal: JAMA (1970)

<h3>To the Editor.—</h3> A man has been drinking, commits a crime or is involved in an accident, and you are asked to examine him in his now sober state for a medicolegal opinion. Hutchinson et al<sup>1</sup>addressed themselves to some of the legal implications of alcohol-mind interaction in their study of the effects of alcohol on mental function. However, since the latter study, new information on the effects of alcohol on memory has become available which raises new questions of legal responsibility. Alcohol and other depressant drugs have been used to produce state-dependent or "dissociated" learning in animals and man.<sup>2,3</sup>That is, learning obtained when a subject is under the effects of a drug can best be recalled when the subject is replaced in the same drug state and is poorly or not remembered in the nondrug state. The higher the dose of the drug, the greater the
Cyclic adenosine monophosphate-dependent kinase in cystic fibrosis tracheal epithelium.
Authors: R Barthelson, J Widdicombe
Journal: Journal of Clinical Investigation (1987)

Cl-impermeability in cystic fibrosis (CF) tracheal epithelium derives from a deficiency in the beta-adrenergic regulation of apical membrane Cl- channels. To test the possibility that cAMP-dependent kinase is the cause of this deficiency, we assayed this kinase in soluble fractions from cultured airway epithelial cells, including CF human tracheal epithelial cells. Varying levels of cAMP were used in these assays to derive both a Vmax and apparent dissociation constant (Kd) for the enzymes in soluble extracts. The cAMP-dependent protein kinase from CF human tracheal epithelial cells has essentially the same Vmax and apparent Kd as non-CF human, bovine, and dog tracheal epithelial cells. Thus, the total activity of the cAMP-dependent kinases and their overall responsiveness to cAMP are unchanged in CF.
A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A.
Authors: H Wu, S K Mahata, M Mahata, N J Webster, R J Parmer, D T O'Connor
Journal: Journal of Clinical Investigation (1995)

Chromogranin A, a soluble acidic protein, is a ubiquitous component of secretory vesicles throughout the neuroendocrine system. We reported previously the cloning and initial characterization of the mouse chromogranin A gene promoter, which showed that the promoter contains both positive and negative domains and that a proximal promoter spanning nucleotides -147 to +42 bp relative to the transcriptional start site is sufficient for neuroendocrine cell type-specific expression. The current study was undertaken to identify the particular elements within this proximal promoter that control tissue-specific expression. We found that deletion or point mutations in the potential cAMP response element (CRE) site at -68 bp virtually abolished promoter activity specifically in neuroendocrine (PC12 chromaffin or AtT20 corticotrope) cells, with little effect on activity in control (NIH3T3 fibroblast) cells; thus, the CRE box is necessary for neuroendocrine cell type-specific activity of the chromogranin A promoter. Furthermore, the effect of the CRE site is enhanced in the context of intact (wild-type) promoter sequences between -147 and -100 bp. DNase I footprint analysis showed that these regions (including the CRE box) bind nuclear proteins present in both neuroendocrine (AtT20) and control (NIH3T3) cells. In AtT20 cells, electrophoretic mobility shift assays and factor-specific antibody supershifts showed that an oligonucleotide containing the chromogranin A CRE site formed a single, homogeneous protein-DNA complex containing the CRE-binding protein CREB. However, in control NIH3T3 cells we found evidence for an additional immunologically unrelated protein in this complex. A single copy of this oligonucleotide was able to confer neuroendocrine-specific expression to a heterologous (thymidine kinase) promoter, albeit with less fold selectivity than the full proximal chromogranin A promoter. Hence, the CRE site was partially sufficient to explain the neuroendocrine cell type specificity of the promoter. The functional activity of the CRE site was confirmed through studies of the endogenous chromogranin A gene. Northern mRNA analysis showed that expression of the endogenous chromogranin A gene was stimulated seven- to eightfold by cAMP in PC12 cells, whereas no induction occurred in the NIH3T3 cells. Similar cAMP induction was obtained with the transfected chromogranin A promoter in PC12 cells, and abolition of the CRE site (by deletion or point mutation) eliminated the induction. Thus, the CRE site in the chromogranin A proximal promoter is functional and plays a crucial, indeed indispensable, role in neuroendocrine-specific expression of the gene. These results also provide insight into transcriptional mechanisms governing acquisition of the neuroendocrine secretory phenotype.