tbuckley/cabot-search huggingface dataset:
Transfusion‐related acute lung injury following intravenous anti‐D administration in an adolescent
Authors: Sivan Berger‐Achituv, Martin H. Ellis, Brian R. Curtis, Baruch Wolach
Journal: American Journal of Hematology (2008)

Transfusion-related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14-year-old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti-D. Full blown noncardiogenic pulmonary edema was noted after 9 hr. Mechanical ventilation was not required and the patient made a full recovery after 36 hr. Analysis of the anti-D preparation revealed reactivity against the neutrophil FcgammaRIIIb. A postinfusion serum sample contained antibodies against class I human HLA-A11 antigen. Clinicians should consider TRALI in patients developing unexplained dyspnea after receiving intravenous anti-D.
Remarks ON CHRONIC INTESTINAL STASIS: WITH REFERENCE TO CONDITIONS FOUND AT OPERATION AND THE MORTALITY
Authors: Wm. S. Bainbridge
Journal: BMJ (1913)

To Sir Arbthtliuot Lane we are greatly indebted, for lhe lias given to us a very clear view of tlle essential facts concerning stasis.He lias evolved a most plausible theory as to its cause, and has pictured the far-reaching effects.The cases hle has presented are mnost convincing, especially so when we realize that they are not a small group of exceptions.We have seen seventeen patients to-day, many of them forlmner hunman derelicts, now made over into useful and happy people.Dturing tile past six years I have miade five trips to England, and each time lhave studied the subject of chlronic intestinal stasis.Every facility has been freely granted by Sir Arbuthnot for tilis work.Year after year I have seen his patienbs before operation,
Follow-up Status of Patients With Angiographically Normal Coronary Arteries and Panic Disorder
Authors: Bernard D. Beitman
Journal: JAMA (1991)

Cardiology patients with normal coronary angiography demonstrate continuing and substantial social, health, and work disability. We hypothesized that the diagnosis of panic disorder would mark those for whom continuing disability is most likely. We interviewed 72 such patients at the time of their normal angiogram, and then again an average of 38 months later. Those with panic disorder (n = 36) demonstrated significantly more disability at follow-up than did the other study patients. We conclude that those patients with normal angiograms who have panic disorder are more disabled than those who do not have panic disorder. Panic disorder in psychiatric samples has been shown to be highly treatable. Therefore, early identification and treatment of panic disorder in this group is likely to minimize the suffering associated with this condition.
847-4 Asymmetric dimethylarginine and the risk of coronary heart disease: Relationship with traditional risk factors as assessed in the multicenter CARDIAC study
Authors: Rainer H Boger, Henrike Lenzen, Christoph Hanefeld, Asja Bartling, Karl J Osterziel, Magda Kusus, Caroline Schmidt-Lucke, Dietrich Strodter, Jurgen Berger, Lilia Goudeva, Andreas Mugge
Journal: Journal of the American College of Cardiology (2004)
Purging and Calorie Absorption in Bulimic Patients and Normal Women
Authors: GEORGE W. BO-LINN
Journal: Annals of Internal Medicine (1983)

Self-induced purging with laxatives is common among bulimic persons, who assume that purging reduces intestinal absorption of ingested calories. However, the efficacy of purging in reducing calorie absorption has never been studied, probably because the standard calorie balance procedure is expensive and time consuming. With a recently devised method, calorie absorption during a single day was measured to determine to what extent Phenolphthalein or saline purge reduced calorie absorption. In two bulimic patients who regularly used laxatives for weight control and five normal young women, even extreme purging producing 4 to 6 L of diarrhea caused calorie absorption to decrease by only about 12% of calorie intake. The theoretical basis on which laxatives are taken for weight control is unsound.
Sulfated glyco-block copolymers with specific receptor and growth factor binding to support cell adhesion and proliferation
Authors: Zeynep Oezyuerek, Katja Franke, Mirko Nitschke, Roland Schulze, Frank Simon, Klaus-Jochen Eichhorn, Tilo Pompe, Carsten Werner, Brigitte Voit
Journal: Biomaterials (2008)
Marijuana and Amphetamine: The Question of Interaction
Authors: STEVEN ZALCMAN, BARRY LISKOW, REMI CADORET, DONALD GOODWIN
Journal: American Journal of Psychiatry (1973)

Animal studies have indicated that marijuana has both a depressive and an excitatory effect on the central nervous system. Since drug users occasionally combine marijuana and amphetamines, a study was performed to determine whether the two drugs have an interaction effect on a variety of physiologic and psychological measures. In general, no such interaction was demonstrated. Previously reported physiological effects of marijuana and amphetamines were confirmed, although some of the psychological effects were at variance with previously reported findings.
Activity of Intoplicine (RP60475), a New DNA Topoisomerase I and II Inhibitor, Against Human Tumor Colony-Forming Units In Vitro
Authors: J. R. Eckardt, H. A. Burris, J. G. Kuhn, M. C. Bissery, M. Klink-Alakl, G. M. Clark, D. D. Von Hoff
Journal: JNCI Journal of the National Cancer Institute (1994)

Intoplicine (RP60475) is the most active analogue evaluated in the 7 H -benzo[e]-pyrido-[4, 3- b ]-indoleseries of antineoplastic compounds. It exerts its activity through inhibition of DNA topoisomerase I and II. This study was planned to determine plasma concentrations of intolicine necessary for optimal clinical antitumor activity, as well as to pinpoint possible responsive tumor types that can be included in phase II clinical studies. Tumor specimens were collected from patient as part of routine clinical measures. Single-cell suspensions were prepared from freshly obtained solid tumor biopsy specimens and were exposed to intoplicine either for 1 hour or continuously. The sensitivity of these specimens to intoplicine was evaluated in a human tumor soft-agar cloning assay. Response was considered positive when the colony-forming unit count in drug-treated samples was 50% or less than the response of control tumor samples treated with saline. With 1-hour exposure to intoplicine at final concentrations of 2.5 μg/mL and 10.0 μg/mL , 26% and 54% of the assessable specimens showed positive in vitro reponses, respectively. With continuous exposure to intoplicine at concentrations of 0.25 μg/mL and 2.5 μg/mL and 2.5 μg/mL, 16% and 71% of the assessable specimens showed positive responses, respectively. Activity was seen against breast (71%), non-small-cell lung (69%), and ovarian (45%) cancer colony-forming units at a intoplicine concentration of 10.0 μg/mL after 1-hour exposure. Incomplete cross-resisstance with doxourbicin, cisplatin, fluorouracil, 4-hydroperoxyclophosphamide, vinblastine, and etoposide was also observed. Intoplicine appears to be active in vitro against a variety of human tumors, including a subgroup of tumors insensitive in vitro to standard antineoplastic compounds. If plasma levels of 10.0 μg/mL can be achieved in subjects in ongoing clinical trials, intoplicine could have significant clinical activity. These data indicate that further investigation of intoplicine is warranted. [J Natl Cancer Inst 86:30–33, 1994]
Prevalence of peptic ulcer in India: an endoscopic and epidemiological study in urban Kashmir.
Authors: M S Khuroo, R Mahajan, S A Zargar, G Javid, S Munshi
Journal: Gut (1989)

The prevalence of peptic ulcer disease in the general population of Kashmir, India, was determined by endoscopy in a randomly selected sample population of 2763 adults aged 15 years and above who were interviewed using a questionnaire. Of 239 persons with ulcer symptoms, 193 (80.7%) had an oesophagogastroduodenoscopy. A randomly selected 177 individuals from among the remaining population without ulcer symptoms, were also endoscoped. The point prevalence of peptic ulcer was 4.72% and the lifetime prevalence was 11.22%. The duodenal to gastric ulcer ratio was 17.1:1. Duodenal and gastric ulcer were common in men. The prevalence of peptic ulcer increased with age, with a peak prevalence of 28.8% in the 5th decade of life. Peptic ulcer was not related to socio-economic status. The prevalence of complications, such as bleeding, stenosis, or perforation were similar to those reported in the West.
Altered expression of gangliosides in erythrocytes of paroxysmal nocturnal hemoglobinuria.
Authors: H Nakakuma, T Kawaguchi, K Horikawa, M Hidaka, Y Yonemura, M Kawakita, T Kagimoto, M Iwamori, Y Nagai, K Takatsuki
Journal: Journal of Clinical Investigation (1990)

In paroxysmal nocturnal hemoglobinuria (PNH), impaired glycosyl-phosphatidylinositol (PI)-anchoring of membrane proteins such as decay-accelerating factor has been known to lead to increased susceptibility to complement. Moreover, abnormal expression of non-PI-anchoring glycoproteins such as C3b/C4b receptor (CR1) or glycophorin-alpha also has been shown in PNH. Therefore, we biochemically analyzed glycosphingolipids (GSL) as one of the membrane glycoconjugates of PNH erythrocytes. Erythrocytes of all seven PNH patients showed altered expression of sialosyl GSL (gangliosides) as compared with the control erythrocytes of healthy donors. Both a sialosylparagloboside (IV6NeuAc-nLc4Cer) among four major gangliosides and some minor gangliosides in normal erythrocytes variably disappeared in erythrocytes from the peripheral blood of PNH patients. As one of the possible mechanisms of altered expression of gangliosides in PNH erythrocytes, structural analysis suggested impaired sialylation of GSL. These results suggest not only the altered metabolism of gangliosides in PNH erythrocytes, but also a metabolic disorder of membrane glycoconjugates as a new feature of PNH.
Rectosigmoid Endometriosis: Endoscopic Ultrasound Features and Clinical Implications
Authors: None Roseau, None Dumontier, None Palazzo, None Chapron, None Dousset, None Chaussade, None Dubuisson, None Couturier
Journal: Endoscopy (2000)

Background and Study Aims: The main area of the gastrointestinal tract affected by deep pelvic endometriosis is the rectosigmoid colon in 3 - 37 % of cases. Due to the risk of infiltration and the clinical symptoms of endometriosis, with pain and infertility, the condition may require surgical resection. Preoperative imaging diagnosis of rectosigmoid involvement is therefore important. Rectal endoscopic ultrasonography (EUS), which is already used for the staging of anorectal carcinoma and submucosal lesions, may be a promising technique for this indication. The present study was conducted in order to describe the endosonographic appearance of rectosigmoid endometriosis, and to define the potential relevance of the technique to the choice of resection method.
At least 20 trusts will not reach foundation trust status by 2014, says NAO
Authors: A. Gulland
Journal: BMJ (2011)

At least 20 NHS trusts face such severe financial problems that they have declared that they will not be able to reach foundation trust status in their current form.

A report by the National Audit Office (NAO) says out of the 113 trusts that are currently hoping to become self governing by 2014, at least 20 will be unable to do so. Financial concerns are the most common problem, but poor clinical quality or governance or both are also to blame.

The NAO said that these problems were often “deep seated and long standing.” Mark Davies, director of health value for money studies at the audit office, said: “There are at least 20 trusts out there that have declared themselves unviable at this point in their current form. They don’t believe that whatever they do locally they can meet Monitor’s requirements [to become foundation trusts].” He said more may identify themselves as …
Health needs of women who have sex with women
Authors: Julietta Patnick, Catherine M Davison
Journal: BMJ (2004)

Editor—With reference to the editorial by Hughes and Evans, we emphasise that the NHS cervical screening programme offers cervical screening to all women without inquiring about their sexual behaviour.1

We agree that many women who have sex with women have, at some time, also had a sexual relationship with a man, and their risk is no less than for the majority of the population. Women who have never been sexually active with a man are equally entitled to cervical screening and may wish to discuss their situation with their general practitioner or sexual health adviser before making an informed decision about whether to participate in the programme or not.
UK hip fracture audit is launched to improve care and reduce costs
Authors: Susan Mayor
Journal: BMJ (2007)

A new UK-wide audit has been launched to improve the care of patients with hip fracture. The audit aims to help reduce the currently low and variable rates of investigation and treatment of osteoporosis in elderly people who are admitted to hospital with fragility fractures.

The audit system, called the national hip fracture database, will gather data submitted voluntarily by hospitals around the United Kingdom. Its design is based on an audit of myocardial infarction care, the myocardial infarction national audit project (MINAP), which has had a major role in improving the management of heart …
Phytophotodermatitis (Solar Dermatitis from Plants)
Authors: Robert G. Sommer, Otis Field Jillson
Journal: New England Journal of Medicine (1967)

THE dermatologic and general medical literature contains the names of numerous plants of wide distribution that are alleged to cause phytophotodermatitis. These plants contain furocoumarins (psoralens), which act as photosensitizers.1 , 2 Many of the plants exist in New England, but proved photosensitization is a rare event indeed. Our attempts to produce dermatitis with 2 of these plants, the buttercup and the wild carrot, have been unsuccessful. There are in the Northeast, however, at least 2 plants that are common and readily cause photodermatitis – the wild parsnip3 and the gas plant.4 The currently preferred medical term for the disease produced by . . .
Changing pattern of drugs used for self-poisoning.
Authors: A T Proudfoot, J Park
Journal: BMJ (1978)

In 1967-76 the annual number of admissions to a poisoning treatment centre rose from 964 to 2134. The proportion of admissions caused by taking barbiturate hypnotics and methaqualone fell considerably while that caused by taking benzodiazepines and tricyclic antidepressants increased. As a result the proportion of patients admitted unconscious fell from 23% to 15%. The declining contributions of barbiturates and methaqualone and increased importance of tricyclic antidepressants were significant in all grades of coma. The change in drugs taken, however, has not yet reduced the percentage of unconscious patients needing endotracheal intubation or assisted ventilation, and hypothermia remains as common. Only hypotension has become less frequent as antidepressants replace barbiturates as the main cause of drug-induced coma. The use of salicylates for self-poisoning is declining slowly, and paracetamol poisoning is now as common.
Blood Pressure and Progression of Brain Atrophy
Authors: Hadassa M. Jochemsen
Journal: JAMA Neurology (2013)

Studies have shown that both high and low blood pressure (BP) may play a role in the etiology of brain atrophy. High BP in midlife has been associated with more brain atrophy later in life, whereas studies in older populations have shown a relation between low BP and more brain atrophy. Yet, prospective evidence is limited, and the relation remains unclear in patients with manifest arterial disease.To examine the associations of baseline BP and change in BP over time with progression of brain atrophy.The Secondary Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) Study is a prospective cohort study with baseline measurements in 2001-2005 and follow-up measurements in 2006-2009. The mean follow-up time was 3.9 years.University Medical Center Utrecht, the Netherlands.A total of 663 patients (mean [SD] age, 57 [9] years; 81% male) with coronary artery disease, cerebrovascular disease, peripheral artery disease, or abdominal aortic aneurysm were included.Using automated segmentation at baseline and follow-up, change in brain parenchymal fraction, cortical gray matter fraction, and ventricular fraction (%ICV) were quantified as indicators of progression of global, cortical, and subcortical brain atrophy.Multivariable adjusted regression analysis showed that patients with lower baseline diastolic BP (DBP) or mean arterial pressure had more progression of subcortical atrophy. The mean differences in the change in ventricular fraction between low and high DBP was 0.07% (95% CI, 0.01-0.14) and between low and high mean arterial pressure was 0.05% (95% CI, 0.00-0.10). Furthermore, in patients with higher baseline BP (DBP, mean arterial pressure, or systolic BP), those with declining BP levels over time had less progression of subcortical atrophy compared with those with rising BP levels.In patients with manifest arterial disease, low baseline DBP was associated with more progression of subcortical atrophy, irrespective of the BP course during follow-up. Furthermore, in patients with higher baseline BP, declining BP levels over time were associated with less progression of subcortical atrophy. This could imply that BP lowering is beneficial in patients with higher BP levels, but caution should be taken with further BP lowering in patients who already have a low DBP.
Development of a personalized cellular ex-vivo cbl-b silencing cancer immunotherapy
Authors: Guenther Lametschwandtner, Hans Loibner, Monika Sachet, Hubert Hayden, Michaela Hassler, Manfred Schuster, Marc Salzberg, Pierre Triozzi, Josef Friedl
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts The E3 ubiquitin ligase cbl-b has been identified as an important gatekeeper limiting T cell activation. Concordantly, the immune system of cbl-b deficient mice can effectively fight tumors, thereby validating cbl-b as an excellent target to enhance anti-tumor immune activity. We
EVALUATION OF 153SAMARIUM EDTHP (153SM-EDTMP) AS A BONE IMAGING AGENT DURING THERAPEUTIC TRIALS
Authors: D. A. Podoloff, L. P. Kasi, E. E. Kim, F. Fosella, V. Bhadkamkar
Journal: Clinical Nuclear Medicine (1991)

Podoloff, D. A.; Kasi, L. P.; Kim, E. E.; Fosella, F.; Bhadkamkar, V. U.T. M.D Author Information
Hypertension and Stroke: Pathophysiology and Management
Authors: Panayiotis N. Varelas
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemotherapy of Bronchitis
Authors: K. Zinnemann, J. Frazer
Journal: BMJ (1970)

Plasma 11-OHCS and Questionary Results (Means + S. D.) This small study suggests that poor short- term response to antidepressants is related to hypothalamic dysfunction.This lack of response and the presence of hypothalamic dysfunction could not have been predicted from clinical or questionary data.Further studies of specific treatment responses and tests of hypothalamic function are needed in depressed patients.If these findings are replicated, they may be of clinical value in deciding on appropriate treatment for the particular patient and may help in eluci- dating the action of antidepressants.-Weare, etc.,
Fitz-Hugh-Curtis Syndrome
Authors: John A. Reichert
Journal: JAMA (1976)

Four of our patients had classical Fitz-Hugh-Curtis syndrome. Persistent right upper-quadrant pain prompted extensive medical evaluation; antibiotic therapy failed to relieve the symptoms. In each case, laparoscopy proved to be an ideal method for obtaining definitive diagnosis and therapy. Typical perihepatic violin-string adhesions were cauterized and divided under direct vision, with dramatic resolution of symptoms. (<i>JAMA</i>236:266-268, 1976)
Abstract 2512: Epothilone B enhances surface EpCAM expression in ovarian cancer cells
Authors: Shohreh Shahabi, Chia-Ping H. Yang, Gary Goldberg, Susan B. Horwitz
Journal: Cancer Research (2010)

Abstract OBJECTIVES Epothilone B (EpoB), like Taxol, induces tubulin polymerization and microtubule stabilization resulting in an inhibition of microtubule dynamic instability. The drug is presently being evaluated in phase III clinical trials. An EpoB analog Ixabepilone, has been approved by the FDA for the treatment of metastatic breast cancer. Epithelial cell adhesion antigen (EpCAM) expression is significantly higher in epithelial ovarian cancer cells compared to normal cells. METHODS We used biochemical methods, immunofluorescence and flow cytometry to identify EpCAM expression on the surface of the ovarian cancer cell line, Hey, after exposure to EpoB. We also investigated the relationship between EpoB-mediated surface EpCAM expression and EpoB-induced tubulin acetylation in Hey cells. RESULTS We investigated the effect of EpoB and other microtubule-interacting agents on surface EpCAM expression and found that nanomolar concentrations of EpoB, Taxol, discodermolide or vinblastine caused a marked increase in surface EpCAM expression in an ovarian cancer cell line, Hey. Alpha-tubulin acetylation, a surrogate marker for stable microtubules, was increased following treatment with Taxol, EpoB and discodermolide, but not with vinblastine, indicating that drug-enhanced surface EpCAM expression does not correlate with tubulin acetylation or stabilization. Unexpectedly, EpoB did not have a significant effect on EpCAM mRNA expression, nor did it alter the level of total cellular EpCAM in the human ovarian cancer cell line. CONCLUSIONS Our results suggest that disruption of the microtubule cytoskeleton is associated with the redistribution of cell surface antigens in ovarian cancer cells. The increase in cell surface EpCAM antigen density may facilitate the antibody targeting of EpCAM-positive ovarian cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2512.