tbuckley/cabot-search huggingface dataset:
Accumulation of Tc-99m Depreotide (NeoSpect) in Axillary Sweat Glands
Authors: Rimma Danielsson, Margaretha B????th, Karl-Gustav K??lbeck, Julius Klominek, Leif Svensson
Journal: Clinical Nuclear Medicine (2003)

Tc-99m depreotide (NeoSpect) is a radiolabeled somatostatin analog introduced recently for scintigraphic imaging of patients with lung cancer. Eighteen patients were examined 2 to 4 hours after administration of 740 MBq mCi Tc-99m depreotide. In 13 patients (72.2%) bilateral symmetric activity corresponding to the large, deep apocrine sweat glands of the axillae was present. This observation is clinically relevant regardless of its reason or mechanism. It is important to be aware of this reason for activity in the axillae when assessing lymph node involvement not only in patients with lung cancer but also in breast cancer patients using scintigraphy with Tc-99m depreotide.
Plasma-chloride Levels in Hyperparathyroidism
Authors: G. K. McGowan, M. R. Wills
Journal: BMJ (1964)

One vaginal examination at six weeks should be quite sufficient in the majority of cases.Where symptoms or signs suggest erosion, infection, or sub-involution, then by all means modify this, but I cannot accept that it must always be done routinely, and particularly so on the-tenth day.Likewise, if one has followed the haemoglobin ante- natally and it has been satisfactory prior to delivery; and one has been present at delivery and estimated the total loss to be minimal, why repeat it ?Isn't this meddlesome midwifery-or is it just that I am " not with it " ?-I am, etc., West Malling, Kent.J. STUART BROWN.SIR,-Dr.John Gibbens (11 July, p. 125) may be right in contesting a statement that puerperal mastitis will respond to benzylpenicillin, since staphylococci are now so often resistant.But he himself has fallen into error in suggesting ampicillin instead.Methicillin, yes, or cloxacillin, but ampicillin is just as easily destroyed as benzylpenicfllin by staphylococcal penicillinase.-Iam, etc.,
Osteomalacia and Phenytoin Therapy
Authors: Jacqueline A. French
Journal: Annals of Internal Medicine (1994)

Letters1 October 1994Osteomalacia and Phenytoin TherapyJacqueline A. French, MDJacqueline A. French, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-7-199410010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Siddiqui is correct that osteomalacia is the common metabolic bone problem resulting from phenytoin therapy. This may occur in as many as one third of patients, but the effects are more common in polytherapy than in monotherapy. It also may be seen with other antiepileptic drugs that induce hepatic metabolism. However, the changes are minor during the first 2 years of monotherapy with phenytoin [1-4].References1. Levy R, Mattson R, Meldrum B, Henry JK, Dryfuss FE, eds. Phenytoin: Toxicity in Antiepileptic Drugs. 3rd ed. New York: Raven Press Ltd.; 1989:241-55. Google Scholar2. Dellaportas DI, Galbraith AW, Laundy M, Reynolds EH, Marshall WJ, Chanarin I. Chronic toxicity in epileptic patients receiving single drug treatment. Br Med J. 1982; 85:409-10. Google Scholar3. Gough H, Goggin T, Bissessar A, Baker M, Crowley M, Callaghan N. A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy. Q J Med. 1986; 230:569-77. Google Scholar4. Hahn TJ. Bone complications of anticonvulsants. Drugs. 1976; 12:201-11. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1994Volume 121, Issue 7Page: 550KeywordsAntiepileptic drugBone Issue Published: 1 October 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
AN HISTORICAL NOTE ON THE NITS OF THE BODY-LOUSE
Authors: GEORGE PERNET
Journal: British Journal of Dermatology (1918)

Journal Article AN HISTORICAL NOTE ON THE NITS OF THE BODY‐LOUSE Get access GEORGE PERNET, M.D. GEORGE PERNET, M.D. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 30, Issue 4, 1 October 1918, Pages 208–209, https://doi.org/10.1111/j.1365-2133.1918.tb12381.x Published: 01 October 1918
Abstract 3317: The cytosolic domain of a disintegrin and metalloprotease (ADAM)-15 promotes proliferation of non-small cell lung cancer (NSCLC)
Authors: Hsin-Han Hou, Chong-Jen Yu
Journal: Cancer Research (2014)

Abstract Lung cancer is the leading cause of cancer-related deaths in worldwide, including in Taiwan. Lung cancer can typically be grouped into two large categories: small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), which account for 15% and 85% of lung cancers, respectively. Despite the continuing endeavors by scientists and clinicians, the cure rate remains low and there is urgent to develop a novel target for NSCLC therapy. The a disintegrin and metalloprotease (ADAM)-15 is a transmembrane protease mediating a wide variety of activities including proteolysis, adhesion, cell fusion and signaling. The expression of ADAM-15 is significantly up-regulated in NSCLC compared to normal tissue. However, the mechanisms of ADAM-15-modulated tumorigenesis in NSCLC are remained unclear. The external enzymetic activity of ADAM15 doesn’t involve in the common pathways in tumoregenesis of NSCLC, such as HER3-EGFR signaling. ADAM15 isoforms are different in cytoplasmic tails, which may drive different biological behavior through intracellular signaling. Therefore, we hypothesized that the diverse cytosolic domain of ADAM15 isoforms plays a crucial role in tumoregenesis of NSCLC. In this study, using real-time quantitative PCR measuring the mRNA expression of 22 ADAMs in NSCLC, we identified a correlation of higher expression of ADAM15 in NSCLC of non-smokers (p=0.002, compared with ex- and current smokers) and in adenocarcinoma (p=0.038, compared with squamous cell ca). Comparing to non-invasive CL1-0 cells and matched normal tissue, CL1-5 cells and NSCLC tissue expressed more the longest ADAM-15 isoform with the largest amount of Src homology (SH)3-binding domain. The association ADAM-15 with SH3-motif containing protein, growth factor receptor-bound (Grb) 2, promoted the ability of proliferation in NSCLC in vitro and in vivo. In conclusion, we suggested that the cytosolic domain of ADAM-15 promotes proliferation of NSCLC via enhance of Grb2-associated signaling pathways, and the inhibition of ADAM-15 may be a potential therapeutic target for NSCLC. Citation Format: Hsin-Han Hou, Chong-Jen Yu. The cytosolic domain of a disintegrin and metalloprotease (ADAM)-15 promotes proliferation of non-small cell lung cancer (NSCLC). [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3317. doi:10.1158/1538-7445.AM2014-3317
Laparoscopically-Assisted Vaginal Hysterectomy
Authors: L. Minelli, M. Angiolillo, C. Caione, V. Palmara
Journal: Endoscopy (1991)

We report on our initial experience with laparoscopically-assisted vaginal hysterectomy. Seven patients aged 41 to 67 years were successfully treated with this new technique without significant morbidity and with the advantage of early discharge and return to full activity. We discuss the indications, technical details including preparation and positioning, and the shortcomings and problems encountered. It is concluded that laparoscopically-assisted vaginal hysterectomy may in the near future become a valid alternative to the conventional procedures in selected cases.
EGFL7 ligates αvβ3 integrin to enhance vessel formation
Authors: Iva Nikolić, Nevenka Dudvarski Stanković, Frank Bicker, Jeannette Meister, Helene Braun, Khader Awwad, Jan Baumgart, Kirsten Simon, Serge C. Thal, Chinmoy Patra, Patrick N. Harter, Karl H. Plate, Felix B. Engel, Stefanie Dimmeler, Johannes A. Eble, Michel Mittelbronn, Michael K. Schäfer, Benno Jungblut, Emmanouil Chavakis, Ingrid Fleming, Mirko H. H. Schmidt
Journal: Blood (2013)
Intestinal Behçet’s Disease Diagnosed by Capsule Endoscopy
Authors: C. Gubler, P. Bauerfeind
Journal: Endoscopy (2005)

Figure 1 A 24-year-old woman with known Behçet’s disease complained of intermittent cramping abdominal pain. The diagnosis of Behçet’s disease had been based on necrotizing vasculitis at the vulva. The abdominal pain always resolved promptly when steroids were given; no nonsteroidal anti-inflammatory drugs (NSAIDs) were taken. In the middle jejunum, capsule endoscopy revealed pseudopolypoid lesions without villi, as described in enteroclysis studies.
Private Illness and Public Policy: The Cases of James Forrestal and John Winant
Authors: ARNOLD A. ROGOW
Journal: American Journal of Psychiatry (1969)

The illnesses and suicides of James Forrestal and John Winant are examined for their possible relevance to problems of stress and breakdown in political decision-making areas. The depressions of Forrestal and Winant are related to their personal lives and political careers. The author argues that some of their personal problems found expression in their careers but that the serious consequences of these problems for policy decisions were checked by a variety of restrictions on office holding in American government. Much more research is needed, however, to determine what might be done to prevent mental illness and breakdown in high office.
Plasminogen Receptor S100A10 Is Essential for the Migration of Tumor-Promoting Macrophages into Tumor Sites
Authors: Kyle D. Phipps, Alexi P. Surette, Paul A. O'Connell, David M. Waisman
Journal: Cancer Research (2011)

Abstract Macrophages are critical drivers of tumor growth, invasion, and metastasis. Movement of macrophages into tumors requires the activity of cell surface proteases such as plasmin. In this study, we offer genetic evidence that plasminogen receptor S100A10 is essential for recruitment of macrophages to the tumor site. Growth of murine Lewis lung carcinomas or T241 fibrosarcomas was dramatically reduced in S100A10-deficient mice compared with wild-type mice. The tumor growth deficit corresponded with a decrease in macrophage density that could be rescued by intraperitoneal injection of wild-type but not S100A10-deficient macrophages. Notably, macrophages of either genotype could rescue tumor growth if they were injected into the tumor itself, establishing that S100A10 was required specifically for the migratory capability needed for tumor homing. Conversely, selective depletion of macrophages from wild-type mice phenocopied the tumor growth deficit seen in S100A10-deficient mice. Together, our findings show that S100A10 is essential and sufficient for macrophage migration to tumor sites, and they define a novel rate-limiting step in tumor progression. Cancer Res; 71(21); 6676–83. ©2011 AACR.
BLEEDING ESOPHAGEAL VARICES WITHOUT OTHER SIGNS OF HYPERTENSION IN A CHILD
Authors: James Mithoefer
Journal: JAMA (1953)

There are instances in which a careful investigation fails to reveal the source of massive gastrointestinal hemorrhage. When there are secondary evidences of portal hypertension, one concludes that bleeding varices of the esophagus are the cause. The case presented here illustrates that varices of the esophageal veins may be present and may be the source of fatal hemorrhage in childhood without other signs of portal hypertension.  REPORT OF A CASE  This child was 2½ years old at the time of her first admission to the Children's Hospital, Cincinnati, on April 6, 1950, because of massive gastrointestinal hemorrhage. She had been born at term after an uncomplicated pregnancy, and her growth and development had been normal until diarrhea developed 10 months before this admission. After the child had had several watery stools a day for two weeks, her parents noticed that her stools became black and foul smelling and that she
ANTISEPTICS.Read in the Section of Practice of Medicine and Physiology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C. May, 1891.
Authors: HIRAM CORSON
Journal: JAMA (1891)

There has been a decided tendency for the past few years on the part of persons affected by the antiseptic and germ theories, to make it imperative on those who practice midwifery, to obey the rigid antiseptic rules laid down by teachers. I saw somewhere  in a discussion on the necessity for antiseptic measures during parturition, and their continuance during the lying-in period, a prominent physician said that if he should be called on to testify, in a prosecution for malpractice where death had occurred during confinement and antiseptic precautions had not been used, he would certainly testify  it was criminal mal practice. This was an alarming threat, as it placed practitioners of midwifery in constant peril, and it impelled me to speak to our County Medical Society about it, and to urge them to make some preparation for such an emergency. The Society then appointed me to
Corticosteroid Therapy for the Pregnant Asthmatic Patient
Authors: Michael Schatz
Journal: JAMA (1975)

Corticosteroids were used during seventy pregnancies in 55 asthmatic patients. In this series there was one spontaneous abortion and 71 live births (including two sets of twins). There was no maternal, fetal, or neonatal deaths. On the basis of recorded gestation, slightly more premature births were noted in this series than would be expected in the general population. However, there was no increased incidence of toxemia, uterine hemorrhage, or congenital malformations when compared to the general population, Corticosteroids, when indicated for the treatment of severe asthma, do not appear to noticeably increase the risk of maternal or fetal complications, and thus should not be contraindicated in pregnancy.
Predictors of Cord blood IgE levels in Child: Preliminary Results of a Randomized Controlled Trial of Omega-3 PUFA Supplementation During Pregnancy.
Authors: I. Romieu, E. Hernández, A. Barraza-Villarreal, C. Escamilla-Núñez, P. Sly, L. Neufeld, U. Ramakrishnan
Journal: Journal of Allergy and Clinical Immunology (2009)
Tuberculosis – the tide can be turned, the battle can be won
Authors: Alimuddin Zumla
Journal: Journal of the Royal Society of Medicine (2008)

‘I know how debilitating this disease can be. I contracted Tuberculosis at the age of 14 years and was hospitalized for 20 months. I am here to witness that TB is a curable and preventable disease. The battle against TB has been long and hard, but we are making progress, more patients than ever are now detected and cured under the DOTS strategy. But we can and should do more to make available the highest quality of TB care to all and this is what the Global Plan to Stop TB is all about, to halve the number of deaths due to TB by 2015. Treating patients and saving lives is a moral and ethical imperative.’
Abstract 2917: Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma
Authors: Janine G. Einspahr, Valerie S. Calvert, David S. Alberts, Clara Curiel-Lewandrowski, James Warneke, Steven P. Stratton, Lance Liotta, Giovanni Pellacani, Robert Krouse, Anil Prasad, Jianghong Deng, Timothy Bowden, Emanuel F. Petricoin
Journal: Cancer Research (2011)

Abstract In order to identify important cell signaling derangements in squamous cell carcinoma (SCC) and its precursor actinic keratosis (AK) as a means to uncover important molecular targets and further characterize this disease, we analyzed two independent tissue study sets using Reverse Phase Protein Microarrays (RPMA). Set 1 served as a pilot as well as a means to generate candidate pathway alterations that could be further validated in a second independent sample set. Study Set 1 was comprised of 4 AK, 6 advanced SCC (≥ 2 cm), 7 non-advanced SCC, and 20 normal appearing skin samples [upper-inner arm, (UIA)]. Set 2 included15 AK, 5 advanced SCC, 4 non-advanced SCC and 20 UIA. LCM was used to isolate pure populations of epithelial cells. Fifty-one key signaling proteins and phosphorylated proteins were assessed for set 1 showing that the MEK-ERK pathway was activated in SCC compared to AK and normal skin, that EGFR was aberrantly activated in SCC, and that the mTOR pathway was highly activated in SCC. Unsupervised clustering revealed dramatic differences in SCC signaling architecture. Statistical analysis (p&amp;lt;0.01) found that pro-survival signaling through phosphorylation of ASK, and 4EBP1 as well as increased Bax and Bak expression were higher in AK vs UIA. We then expanded our pathway network activation mapping in set 2 to 108 key signaling proteins. We corroborated the MEK-ERK, EGFR and mTOR pathway activation and identified an expanded number of upstream and downstream signaling molecules within these pathways, and that SCC is indeed a pathway activation-driven disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2917. doi:10.1158/1538-7445.AM2011-2917
Fluticasone propionate (FP) CFC delivered via valved holding chamber with facemask for 12 weeks improved asthma control in children aged 24–47 months with asthma
Authors: C.C. Crim, R.A. Nathan, J.W. Baker, G.W. Bensch, M.A. Faris, N.E. Herje, C.A. Scott, W. Wu, C.C. Reisner
Journal: Journal of Allergy and Clinical Immunology (2003)
Allergy Assessment in Patients with Eosinophilic Esophagitis (EE)
Authors: D. Antolin-Amerigo, B. De la Hoz Caballer, F.J. Sola-Martinez, R. Moreno-Borque, P.C. Vlaicu, L.C. Rusu, C. Vidal-Albareda, X. Aguilera, M.S. Terrados-Cepeda, M. Sanchez-Cano, E. Alvarez-Cuesta
Journal: Journal of Allergy and Clinical Immunology (2010)
Congenital obstructive emphysema of the left lung associated with a mediastinal lymphatic cyst.
Authors: D W Man, S T Donell, F Raafat, H B Eckstein
Journal: Thorax (1984)

Congenital obstructive emphysema is an uncommon paediatric condition affecting usually a single lobe, occa- sionally multiple lobes bilaterally, and only rarely a whole lung.This case report describes a neonate with congenital obstructive emphysema of the left lung and an associated lymphatic cyst compressing the left main bronchus, who presented two hours after birth with severe respiratory dis- tress and was treated successfully by pneumonectomy. Case reportA 3-36 kg girl was born to a 24 year old mother at term by normal vaginal delivery.The baby initially failed to breathe spontaneously.The apgar score was 7 at both 1 and 5 minutes.At 2 hours she had failed to feed and was dusky in colour.At 3 hours, with no improvement on pharyngeal suction, she was placed in a head box with 30% oxygen.At 41/2 hours she was transferred to the Hospital for Sick Children, when a left sided diaphragmatic hernia was suspected on a chest radiograph.
YEAST INFECTION IN CHILDREN
Authors: R. Craik
Journal: BMJ (1913)

T BI, TISH 1205 was not detected in the routinie examiinationi of the urine, aind the diagnosis was only made p)ost miorkite.Highl arterial tensioln and conlsequeent clhanlg-es in lhcart anid arteries lhave usually been present in tllese cases, aud lave been reaaided by soImie as constant.They were not recognizable in a case recorded recently, ancd in Cases I and II above tlhey -were not present to any appreciable deglree clinically, in spite of tlle fact that they were care- fully souglht for.There were somiie signs of retinal changes in Case i, and-microseopically the walls of the aLterioles of the kiidneys were distinctly tlhiclkened; but considerilng the extremiie degree of fibrosis of the kidneys alndl tfliir minuilte size, in conjuinction witlh tlle coini- paratively lona duration of the symptoms, any clhanges plCselst would seemi unaccountably slighit.Dr. Sawyer 4 suggests one year as ali average duration of symiiptolmis in simililar cases, and notes tlhree years in the exceptionally lolnger ones; buit this boy had obvious symiiptoms, whlich lhardly varied at all over a period of seven anid a lhalf years.
Lake Nyos disaster, Cameroon, 1986: the medical effects of large scale emission of carbon dioxide?
Authors: P. J. Baxter, M. Kapila, D. Mfonfu
Journal: BMJ (1989)

Carbon dioxide was blamed for the deaths of around 1700 people in Cameroon, west Africa, in 1986 when a massive release of gas occurred from Lake Nyos, a volcanic crater lake. The clinical findings in 845 survivors seen at or admitted to hospital were compatible with exposure to an asphyxiant gas. Rescuers noted cutaneous erythema and bullae on an unknown proportion of corpses and 161 (19%) survivors treated in hospital; though these lesions were initially believed to be burns from acidic gases, further investigation suggested that they were associated with coma states caused by exposure to carbon dioxide in air. The disaster at Lake Nyos and a similar event at Lake Monoun, Cameroon, two years previously provide new information on the possible medical effects of large scale emissions of carbon dioxide, though the presence of other toxic factors in these gas releases cannot be excluded.
Lymphadenopathy Resulting From Acute Hepatitis C Infection Mimicking Metastatic Breast Carcinoma on FDG PET/CT
Authors: Heather A. Jacene, Vered Stearns, Richard L. Wahl
Journal: Clinical Nuclear Medicine (2006)

We report a case documenting fluorodeoxyglucose (FDG) accumulation in upper abdominal lymph nodes resulting from acute hepatitis C infection. A 42-year-old African-American female with a history of metastatic breast carcinoma was found to have hypermetabolic porta hepatic, peripancreatic, and paraaortic lymphadenopathy and hypermetabolism in the spleen on a surveillance FDG positron emission tomography/computed tomography (PET/CT) scan. Concurrently, she was diagnosed with acute hepatitis C infection. Antiviral therapy was not recommended secondary to the low level of detectable virus at the time of diagnosis. Her breast cancer therapy regimen was continued unaltered. FDG PET/CT scan was repeated 2 months later as a result of concern that the hypermetabolic lymph nodes represented metastatic disease; however, the scan revealed complete resolution of the previously abnormal findings. The resolution of the lymphadenopathy and the patient's clinical course led to the conclusion that the most likely explanation for the FDG PET/CT findings was inflammation secondary to acute hepatitis C infection and not metastatic breast carcinoma. Inflammatory and infectious processes accumulate FDG, occasionally resulting in false-positives for malignancy. Infected macrophages in the lymph nodes draining the liver in this case and stimulation of a cellular immune response by the hepatitis C virus, with resultant cytokine production by cytotoxic and T-helper cells, offer possible explanations for the findings seen on FDG PET/CT in this case. This case highlights the importance of clinical history and laboratory correlation for the proper interpretation of FDG PET scans.
Response to Comment on: Wilson et al. Persistence of Individual Variations in Glycated Hemoglobin: Analysis of Data From the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial. Diabetes Care 2011;34:1315–1317
Authors: Darrell M. Wilson, Craig Kollman
Journal: Diabetes Care (2011)

We thank Hempe et al. (1) for their comments and the opportunity to further discuss this issue. They question why we switched from use of hemoglobin glycation index (HGI) (2) to ratios in our analyses of the relation between HbA1c and mean glucose (MG). They suggest that the HGI is superior to the MG-to-HbA1c ratio.

We actually performed parallel analyses with the ratio and the HGI. Because of space limitations, our article focused on results from the ratio, but we did show that results were similar using HGI. This was stated in the article, and the HGI data were made available in supplemental materials on the journal website.

As is often the case when considering different …