tbuckley/cabot-search huggingface dataset:
Urinary N-nitrosoproline excretion: a further evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions.
Authors: C N Hall, J S Kirkham, T C Northfield
Journal: Gut (1987)

Measurement of N-nitroso compounds in gastric juice by different methods has given conflicting results. In order to resolve this controversy, we have assessed endogenous nitrosation by the independent N-nitrosoproline excretion test in subjects who had previously undergone gastric juice analysis by one of these methods. Ten Polya gastrectomy, 10 pernicious anaemia and nine matched control subjects were fed 380 mg of nitrate in beetroot juice and 500 mg proline. N-nitrosoproline (N-Pro) synthesised intragastrically from these precursors, and quantitatively excreted by the kidneys, was measured in 24 hour urine samples (collection checked by creatinine clearance). N-Pro excretion (mean +/- SEM) was reduced (p less than 0.01) in pernicious anaemia (1.1 +/- 0.8 ng/day) compared with matched control (18.0 +/- 7.2 ng/day), and also tended to be lower (NS) in polya gastrectomy (3.2 +/- 2.3 ng/day). Twenty four hour intragastric pH was monitored on a separate occasion in 23 of the 29 subjects; 13 were hypoacidic (pH greater than 4 greater than 50% of 24 hours) and 10 were acidic. N-Pro yields were reduced (p less than 0.01) in the hypoacidic group (0.9 +/- 0.6 ng/day) compared with the acidic group (17.9 +/- 6.6 ng/day), and N-Pro was negatively associated with mean intragastric pH (tau = -0.53, p = 0.001). We conclude that endogenous synthesis of this specific N-nitroso compound is favoured by low rather than high pH. These results are concordant with those previously reported in gastric juice from the same subjects and suggest that nitrosation is chemically rather than bacterially mediated, contrary to the nitrosamine hypothesis of gastric carcinogenesis.
A Membranous Nephrotic Syndrome.
Authors: John D. Arnold
Journal: Annals of Internal Medicine (1964)

s1 October 1964A Membranous Nephrotic Syndrome.John D. Arnold, M.D.John D. Arnold, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-815_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA group of nine patients with a distinctive diffuse lesion of the glomerular basement membrane and the idiopathic nephrotic syndrome have been studied for a decade. These cases have been culled from a series of 500 patients with renal problems including lipoid nephrosis (idiopathic nephrotic syndrome of childhood (INSC)) and systemic diseases.A pattern of ultrastructural alterations can be identified from the comparison of renal biopsies taken serially throughout the course of illness. Early glomerular changes are marked by the diffuse basement membrane widening, conspicuous variations in electron density and the gradual distortion of the adjacent cellular components. The accumulation... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byN-Substituted Silicon-Nitrogen-(Hydrogen) Compounds 1 October 1964Volume 61, Issue 4Page: 815-815KeywordsBasement membraneBiopsyLesionsSystemic diseases ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...
Pathogenic role of IL-17 in endothelial dysfunction, a link between rheumatoid arthritis and atherosclerosis
Authors: A. Hot, V. Lenief, M.-A. Cazalis, P. Miossec
Journal: Annals of the Rheumatic Diseases (2010)

Cardiovascular diseases remain the leading cause of death in rheumatoid arthritis (RA).RA and atherosclerosis share common pathway.Among cytokines involved in RA, interleukin 17 (IL-17) is now seen with a key role.The effect of IL-17 was investigated to better understand its role in endothelial dysfunction, the fi rst step of atherosclerosis.Primary endothelial cells (EC) were treated with IL-17 (100 ng/ml) alone or combined to tumour necrosis factor (TNF)α (1 ng/ml).mRNA expression was quantifi ed by qRT PCR and by Affymetrix microarrays HG133 A+2.The role of IL-17 was evaluated in EC migration and invasion using a chemoinvasion assay through BM matrigel in modifi ed Boyden chambers.The ability of IL-17 to promote thrombosis through platelet aggregation was assessed using platelet rich plasma incubated with IL-17-treated EC supernatants.Coagulation activation was assessed by the expression of tissue factor.IL-17 alone induced pro-infl ammatory changes in EC, inducing changes of 248 genes.A clear synergistic effect was seen with TNFα and their combination enhanced the expression of 9803 genes.Among the critical genes, IL-17 plus TNFα induced synergistically the expression of chemokine genes such as CCL20 and IL-8 and cytokine genes such as IL-6 and IL-15.In contrast, IL-17 decreased the expression of genes involved in the regulation of infl ammation such as IL-4-receptor.Furthermore, IL-17 alone induced the expression of metalloprotease genes such as matrix metalloproteinase 2 (MMP2) and MMP9, known to be involved in atherosclerosis.Using these fi rst results, the effect of IL-17 was tested in a chemo invasion assay through Matrigel to study both cell motility and their ability to cross tissue barriers.IL-17 induced the same level of EC invasion than that induced by TNFα alone.Furthermore, the combination of IL-17 with TNFα resulted in a fi vefold increase in invasive activity.Regarding platelet on May 23,
Induction of lymphoid cell chimerism in noninbred, histocompatible rabbits. A new model for studying allotype suppression in the rabbit.
Authors: L T Adler, F L Adler, C Cohen, R G Tissot
Journal: The Journal of Experimental Medicine (1981)

Noninbred rabbits, matched with regard to the major histocompatibility complex (RLA-A and RLA-D loci) but mismatched for Ig allotypes, served as donors (adult) and recipients (newborn) of lymphoid cells. Lasting chimerism regularly followed the transfer of 1 x 10(8)-3 x 10(8) spleen, lymph node, or bone marrow cells, as indicated by the continued production of Ig with allotypic determinants of both donor and recipient. Typically, Ig of donor allotype accounted for 25-50% of total allotypic Ig at 4 wk of age and the amount of donor Ig produced remained stable for up to 20 mo. Total allotypic Ig levels remained normal in the chimeric rabbits. "Chimeric drift" or a gradual diminution of donor products over a period of several months, occurred in some individuals. Transfer of lymphoid cells from allotype-suppressed adult donors to newborns of appropriate allotypes did not result in specific suppression of the target allotype in the recipients. Other experiments showed that lymphoid cells from suppressed donors adoptively transferred to histocompatible recipients continued to synthesize Ig of the nonsuppressed type only. The suitability of using an outbred population of histocompatible but allotype-mismatched rabbits for analyzing allotype suppression and other immunoregulatory phenomena is demonstrated by the results presented here.
Computational Analysis of Position-dependent Disorder Content in DisProt Database
Authors: Jovana J. Kovačević
Journal: Genomics Proteomics & Bioinformatics (2012)

Abstract A bioinformatics analysis of disorder content of proteins from the DisProt database has been performed with respect to position of disordered residues. Each protein chain was divided into three parts: N- and C- terminal parts with each containing 30 amino acid (AA) residues and the middle region containing the remaining AA residues. The results show that in terminal parts, the percentage of disordered AA residues is higher than that of all AA residues (17% of disordered AA residues and 11% of all). We analyzed the percentage of disorder for each of 20 AA residues in the three parts of proteins with respect to their hydropathy and molecular weight. For each AA, the percentage of disorder in the middle part is lower than that in terminal parts which is comparable at the two termini. A new scale of AAs has been introduced according to their disorder content in the middle part of proteins: CIFWMLYHRNVTAGQDSKEP. All big hydrophobic AAs are less frequently disordered, while almost all small hydrophilic AAs are more frequently disordered. The results obtained may be useful for construction and improving predictors for protein disorder.
Recovery From Severe Metabolic Acidosis
Authors: Marvin R. Goldstein
Journal: JAMA (1975)

To the Editor.—  Recently, a 24-year-old woman was admitted to our emergency ward in profound metabolic acidosis. This was associated with tonic seizures that ultimately proved to be a result of pure strychnine poisoning. The initial pH was 6.57 (checked and rechecked); Po 2 ,140 mm Hg; and Pco 2 , 18 mm Hg. Blood lactate level was 177 mg/100 ml (normal, 0 to 16). Subsequent pH values were 6.70, 6.95, 7.15, and 7.37, giving sodium bicarbonate; ultimately, 35 ampules (each containing 50 ml of 50 mEq sodium bicarbonate 8.4%) were administered intravenously over a 90-minute period. The patient was discharged four days later without sequelae.  I have been unable to find reports of this degree of acidosis associated with survival. I thought this case might prove of interest.
Smallpox Vaccination Risks and Public Policy
Authors: Brian W. Cooper
Journal: Annals of Internal Medicine (2004)

Letters6 January 2004Smallpox Vaccination Risks and Public PolicyBrian W. Cooper, MDBrian W. Cooper, MDFrom Hartford Hospital, Hartford, CT 06078.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-1-200401060-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The review of smallpox vaccination risks and public policy by Lane and Goldstein (1) was timely and informative. However, their recommendation for smallpox-infected patients to wear the N95 respirator in isolation rooms is not necessary and is potentially harmful.The N95 respirator was designed to filter air before being inhaled by the person wearing the respirator, not to filter the expulsion of secretions when breathing, coughing, or sneezing. The N95 and other high-efficiency particulate air–filtered masks subject the wearer to discomfort and increased resistance to breathing as well as increased dead space. This discomfort would probably be ...References1. Lane JM, Goldstein J. Evaluation of 21st-century risks of smallpox vaccination and policy options. Ann Intern Med. 2003;138:488-93. [PMID: 12639083] LinkGoogle Scholar2. Garner JS. Guideline for isolation precautions in hospitals. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol. 1996;17:53-80. [PMID: 8789689] CrossrefMedlineGoogle Scholar3. Guidelines for preventing the transmission of tuberculosis in healthcare facilities. MMWR. 1994;43:1-132. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Hartford Hospital, Hartford, CT 06078. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEvaluation of 21st-Century Risks of Smallpox Vaccination and Policy Options J. Michael Lane and Joel Goldstein Smallpox Vaccination Risks and Public Policy J. Michael Lane and Joel Goldstein Metrics 6 January 2004Volume 140, Issue 1Page: 67KeywordsBreathingCoughingMeaslesMouthParticulatesPathogensPublic policySneezingVentilators ePublished: 6 January 2004 Issue Published: 6 January 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Last Death Song
Authors: Steven F. Gordon
Journal: JAMA (1990)

Death came as no surprise to Mary. She lay in her bed and sang. The third floor of the deteriorating Indian Hospital rang with her voice. She was very old. When Mary had been born, the Battle of Wounded Knee was still news, and the Bureau of Indian Affairs' policy encouraged the sale of reservation lands to non-Indians. The memories of the tribe's five forced moves in 30 years were as strong in her society's memory as the memory of the Holocaust is today. The peyote church came to the reservation and replaced the warrior societies as the social organizing force when Mary was mastering literacy of her own language. The clan system was deteriorating at the beginning of World War II when her grandchildren started to arrive. English had replaced Hochungra as the reservation's main language at the end of the war, and by that time written Hochungra had
Effect of Sabin Poliovirus Vaccine on Incidence of Poliomyelitis in Italy
Authors: A. Giovanardi
Journal: JAMA (1969)

Extensive use of poliomyelitis vaccine (Salk) from 1958 to 1963 did not prevent the annual occurrence of thousands of paralytic cases of poliomyelitis in Italy. After the mass use of live oral poliovirus vaccine (Sabin) early in 1964, the number of reported cases quickly dropped from an average of more than 3,000/year during the four years prior to the use of oral vaccine to 254 in 1965, 147 in 1966, 106 in 1967, and 87 in 1968, and at least a portion of the reported cases could not be confirmed as having been caused by polioviruses. Most of the remaining cases of poliomyelitis have occurred in the southern and island regions (1.17/100,000 vs 0.08 in northern and 0.009 in central Italy in 1965; 0.68/100,000 vs 0.04 in northern, and 0.06 in central Italy in 1966) where the percentage of children vaccinated during the initial campaign and in the ongoing programs was, until recent compulsory vaccination legislation, much less than in the northern and central regions of the country.
THE ACTION AND ROLE OF COLLIDS IN CHEMOTHERAPY
Authors: J.E.R. McDONAGH
Journal: British Journal of Dermatology (1917)

Journal Article THE ACTION AND ROLE OF COLLIDS IN CHEMOTHERAPY Get access J.E.R. McDONAGH, F.R.C.S J.E.R. McDONAGH, F.R.C.S Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 29, Issue 2, 1 April 1917, Pages 93–100, https://doi.org/10.1111/j.1365-2133.1917.tb09658.x Published: 01 April 1917
TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)
Authors: Jean-Luc Bodmer, Kim Burns, Pascal Schneider, Kay Hofmann, Véronique Steiner, Margot Thome, Thierry Bornand, Michael Hahne, Michael Schröter, Karin Becker, Anne Wilson, Lars E. French, Jeffrey L. Browning, H.Robson MacDonald, Jürg Tschopp
Journal: Immunity (1997)
Paris and New York: More in Common Than You Think!
Authors: Hyman B. Muss
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.05.082 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12874268 Paris and New York: More in Common Than You Think! Hyman B. MussxHyman B. MussSearch for articles by this author Show More University of Vermont College of Medicine, Vermont Cancer Center, Burlington, VT https://doi.org/10.1200/JCO.2003.05.082 Full Text PDF Figures and Tables "Paris and New York: More in Common Than You Think!." Journal of Clinical Oncology, 21(17), pp. 3189–3190© 2003 by American Society of Clinical Oncology
George Hoyt Whipple and His Friends: The Life-Story of a Nobel Prize Pathologist.
Authors: William B. Castle
Journal: JAMA (1963)

This delightful and authoritative biography comes from the skillful pen of one who first was Whipple's pupil and then faculty colleague and friend, altogether for more than 50 years. He has successfully conveyed an impression of the dignity, modesty, good sense, and practical idealism of one of the towering figures of American medicine. Written at the request of the Medical Alumni Association of the University of Rochester, the book will be read with pleasure and interest by both doctors and laymen, for it is the story of a man who made many remarkable contributions during a long and productive life as teacher, investigator, and administrator. Whipple's professional career spans almost the entire period of modern scientific medicine in America. Thus, when in 1901 he entered Johns Hopkins Medical School (then reaching its full stature), among his teachers were the original department heads, "the four doctors," Halsted, Kelly, Osler, and Welch.
Agreement of efficacy assessments for five‐grass pollen sublingual tablet immunotherapy
Authors: A. Didier, M. Melac, A. Montagut, M. Lhéritier‐Barrand, A. Tabar, M. Worm
Journal: Allergy (2008)

The optimal dose of five-grass pollen sublingual tablet immunotherapy (SLIT) was established recently by the primary criteria Rhinoconjunctivitis Total Symptom Score (RTSS) from the first treatment season. Secondary and exploratory criteria, such as RTSS at peak pollen season, exploratory combined symptom and rescue medication use score, quality of life and immunological markers are calculated and described in this analysis.Six hundred and twenty-eight patients with grass pollen rhinoconjunctivitis (> or =2 years duration) were randomized in a double-blind, placebo-controlled trial conducted in Europe. Patients received once-daily SLIT (Stallergenes, Antony, France) of 100IR, 300IR, 500IR or placebo, starting 4 months before grass pollen season and throughout the 2005 season. Patients were instructed to take rescue medication only if symptoms were severe and record symptom severity on using the RTSS.Both 300IR and 500IR doses significantly reduced mean RTSS at pollen peak (P = 0.0005 and P = 0.0014, respectively) and the exploratory combined score (P = 0.0001 and P = 0.0026, respectively) compared with placebo. Compared with patients in the placebo group, those who were taking the 300IR and 500IR doses reported significantly improved quality of life using the mean Rhinoconjunctivitis Quality of Life Questionnaire scores during the peak of the pollen season (P < 0.0001) and at the end of the pollen season (P = 0.0031 and P < or = 0.0001, respectively). Specific immunoglobulin G4 increased significantly depending on the SLIT dose (P < 0.0001).All secondary efficacy criteria, including efficacy at pollen peak, combined score, quality of life and immunological changes, indicate that 300IR tablets represent the optimal dose and suggest it is appropriate for use in clinical practice.
Reversal of slow or no-reflow during percutaneous tranluminal coronary angioplasty using boluses of intracoronary adenosine and sodium nitroprusside in combination
Authors: Keyur H. Parikh, Milan C. Chag, Urmil G. Shah, Hemang A. Baxi, Anish H. Chandarana, Ajay M. Naik, Kanan J. Shah, Ramesh K. Goyal
Journal: Journal of the American College of Cardiology (2003)
Comparison of Three Schedules of Intravesical Epirubicin in Patients with Non–Muscle-Invasive Bladder Cancer
Authors: Kees Hendricksen, Wim P.J. Witjes, Jan G. Idema, Jan J.M. Kums, Oncko B. van Vierssen Trip, Marcel J.F.M. de Bruin, Henk Vergunst, Christien T.M. Caris, Maria H.D. Janzing-Pastors, J. Alfred Witjes
Journal: European Urology (2007)
Absence of Intestinal Parasites in Asthma
Authors: Richard G. Van Dellen, John H. Thompson
Journal: New England Journal of Medicine (1971)

To confirm or refute the report by Tullis1 that 198 of 201 patients with bronchial asthma had one of three intestinal parasites, we looked for parasites in 258 stool specimens from 123 patients with both intrinsic and extrinsic asthma. All stools were negative for Ascaris lumbricoides, Strongyloides stercoralis, and Necator americanus, the three parasites found by Tullis. On the basis of findings in 49 of our patients who had at least three negative stools, we estimate (upper 95 per cent confidence level, from [1 — p]49 = 0.05) that not more than 6 per cent of persons with three stools examined would be positive for the parasites. Since Tullis found parasites in 49 per cent of his patients after examination of three stools, we were unable to confirm his findings.
"Responsible Medical Officer"
Authors: D. H. Ropschitz
Journal: BMJ (1967)

example-English doctors.Surely the sen- sible thing for the Government of Pakistan would be to encourage these doctors to return to Pakistan, and if necessary " exploit" the services of their wives.England may suffer by losing these qualified people, but surely Pakistan's need of their services is even greater.The B.M.A. has played a great part in medical history, and surely its sister associa- tion, with Professor Hamid Ali Khan in the chair, could follow its example in this way and attempt the abolition of the reverse "'colour bar."I hope many of my fellow- countrymen will pluck up courage to fight this absurd undemocratic law and injustice.I also must remain anonymous.-Iam, etc., ANON.
Turf Battles in Coronary Revascularization
Authors: Robert S. Huckman, Gary P. Pisano
Journal: New England Journal of Medicine (2005)

When percutaneous transluminal coronary angioplasty (PTCA) entered mainstream use in the early 1980s, it represented a suboptimal substitute for coronary-artery bypass grafting (CABG). Over time, however, the outcomes of PTCA improved, and the technique became a viable alternative to CABG, even in the treatment of patients with advanced coronary disease. Nevertheless, the extent of the diffusion of PTCA as compared with CABG varied widely among hospitals. Several years after the introduction of PTCA, traditional CABG surgery was faced with a new competitor — minimally invasive cardiac surgery. Although the less invasive technique had clear advantages for some types of patients, . . .
The Correlation of Medical Poor Relief and Public Health Administration
Authors: H. W. Rumsey
Journal: BMJ (1874)

Serial neuropsychological testing potentially provides a powerful tool for tracking disease progress and identifying treatment response. Formal neuropsychometric assessment by a clinical psychologist is ideal but impractical for regular testing. Remote computerised assessment resolves this difficulty by allowing frequent home assessment, but is potentially limited by patient compliance and practise effects. We study the feasibility of this approach in an on-going clinical trial investigating the effects of methylphenidate on cognition after traumatic brain injury (TBI): Dopamine9s Role in Enhancing Attention and Memory (DREAM). A battery of neuropsychological tests was delivered on an iPad. 12 patients with moderate/severe TBI and on-going cognitive complaints completed 7 tasks assessing information processing speed, memory, attention and executive functions. The 25-minute-long battery was performed daily for 4 weeks, following an initial training period. Compliance was good, with over 80% of the sessions completed, and patients found it both beneficial and enjoyable. Despite optimising the battery to minimise learning effects, differing tasks showed varying degrees of practise effects. We demonstrate a proof of principle that TBI patients will enthusiastically complete regular computerised neuropsychological tests at home. This provides a potentially powerful tool to assess treatment response, but also offers the prospect of facilitating self-directed cognitive rehabilitation.