Levothyroxine-Cholestyramine Interaction Reemphasized
Authors: Susan M. Harmon, Charles F. Seifert
Journal: Annals of Internal Medicine (1991)

Letters15 October 1991Levothyroxine-Cholestyramine Interaction ReemphasizedSusan M. Harmon, MD, Charles F. Seifert, PharmDSusan M. Harmon, MD, Charles F. Seifert, PharmDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-8-658_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors: Several clinically significant interactions have been reported with bile acid sequestrants, including digoxin, warfarin, thiazide diuretics, corticosteroids, and levothyroxine (1). To date, only one case report of cholestyramine interference with levothyroxine with subsequent clinical hypothyroidism has been reported (2). We report the case of a patient who received concomitant cholestyramine and levothyroxine and developed elevations in the thyroid-stimulating hormone (TSH) level. On the same dose of levothyroxine after discontinuation of the cholestyramine, the patient's TSH level returned to normal.A 51-year-old man with known coronary artery disease and hypothyroidism was noted on 5 July 1990 to have...References1. TatroOHnHebel DBS., eds. Drug Interaction Facts. St. Louis, Missouri: Facts and Comparisons Division, J. B. Lippincott Company; 1991. Google Scholar2. NorthcuttStielHollifieldStant RJJE. The influence of cholestyramine on thyroxine absorption. JAMA. 1969;208:1857-61. CrossrefMedlineGoogle Scholar3. BergmanHeedmanvan der Linden FPW. Influence of cholestyramine on absorption and excretion of thyroxine in Syrian hamster. Acta Endocrinol. 1966;53:256-63. CrossrefMedlineGoogle Scholar4. WitztumJacobsSchonfeld JLG. Thyroid hormone and thyrotropin levels in patients placed on colestipol hydrochloride. J Clin Endocrinol Metab. 1978;46:838-40. CrossrefMedlineGoogle Scholar5. Cashin-HemphillSpencerNicoloffBlankenhornNessimChin LCJDSH. Alterations in serum thyroid hormonal indices with colestipol-niacin therapy. Ann Intern Med. 1987;107:324-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNeither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical dataPersistent Hypothyroidism Despite Levothyroxine Replacement Therapy: Malabsorption or Patient NoncomplianceNonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to FutureFactors Affecting Gastrointestinal Absorption of Levothyroxine: A ReviewSoy and Health Update: Evaluation of the Clinical and Epidemiologic LiteratureHypothyroidism and Myxedema Coma77-Year-Old Man With Hypothyroidism, Right Upper Quadrant Pain, and DiarrheaCholesterol and fat lowering with hydrophobic polysaccharide derivativesThe Effect of Medications on Thyroid Function TestsCrise thyréotoxique : adjonction de la colestyramine au traitement conventionnelLevothyroxine Pseudomalabsorption and Thyroxine Absorption Testing with Use of High-Dose Levothyroxine: Case Report and DiscussionCommon drug interactions leading to adverse drug events in the intensive care unit: Management and pharmacokinetic considerationsInfluence of Drugs on Thyroid Function TestsHypothyroidism and Myxedema ComaInvestigating the Optimal Soy Protein and Isoflavone Intakes for Women: A PerspectiveDrugsSeguridad farmacológica y ambiental: disrupción endocrina tiroideaMontmorillonite ameliorates hyperthyroidism of rats and mice attributed to its adsorptive effectEffects of Soy Protein and Soybean Isoflavones on Thyroid Function in Healthy Adults and Hypothyroid Patients: A Review of the Relevant LiteratureThe effect of combination therapy with propylthiouracil and cholestyramine in the treatment of Graves' hyperthyroidismTablet Formulation of Levothyroxine Is Absorbed Less Well Than Powdered LevothyroxineExaggerated Levothyroxine Malabsorption Due to Calcium Carbonate Supplementation in Gastrointestinal DisordersEffect of Levothyroxine Administration Time on Serum TSH in Elderly PatientsBile Salt Anion Sorption by Polymeric Resins: Comparison of a Functionalized Polyacrylamide Resin with CholestyramineFUNCTIONALIZED β-CYCLODEXTRIN POLYMERS FOR THE SORPTION OF BILE SALTSThyroid Hormone Replacement Therapy for Primary and Secondary HypothyroidismRole of colestipol in the treatment of hyperthyroidismEffects of Pharmacological Fiber Supplements on Levothyroxine AbsorptionConcomitant administration of cholestyramine influences the absorption of troglitazoneBinding of Bile Acids by Polymerized Cyclodextrin ResinsDrugs and Thyroid FunctionIon Exchange ResinsHydrocortisone-Colestipol InteractionThyroid hormones, iodine and antithyroid drugs 15 October 1991Volume 115, Issue 8Page: 658-659KeywordsBileDiureticsHypothyroidismStable coronary artery diseaseThyroid-stimulating hormoneThyroxine Issue Published: 15 October 1991 PDF DownloadLoading ...