tbuckley/cabot-search huggingface dataset:
Gifts to Physicians From Industry
Authors: Adam O. Goldstein
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Controversy surrounds the relationship between the pharmaceutical industry and physicians.<sup>1-3</sup>Congressional hearings have focused on the extravagant gifts that some physicians have received from pharmaceutical companies, implying that many physicians routinely accept these gifts (<i>Am Med News</i>. December 28, 1990). Recently, the American Medical Association (AMA) published guidelines stating that gifts to physicians are acceptable if they entail a benefit to patients and are of no substantial value.<sup>4</sup>Gifts of minimal value are also acceptable if they are related to the physician's work.<sup>4</sup>Despite these reports, there are few data in the medical literature examining to what extent current pharmaceutical gift-giving behaviors may comply with recent guidelines. Exhibit hall gift promotions are a common part of major medical meetings. While attending a recent national meeting of a major medical specialty, I studied a selection of pharmaceutical exhibits to determine the types and proportions of
Benazepril plus amlodipine reduced CV events more than benazepril plus hydrochlorothiazide in hypertension with or without diabetes
Authors: Srinivas Merugu
Journal: Annals of Internal Medicine (2010)

ACP Journal Club19 October 2010Benazepril plus amlodipine reduced CV events more than benazepril plus hydrochlorothiazide in hypertension with or without diabetesSrinivas Merugu, MDSrinivas Merugu, MDSt. Vincent Charity Medical Center, Cleveland, Ohio, USA (S.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-8-201010190-02002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationWeber MA, Bakris GL, Jamerson K, et al. Cardiovascular events during differing hypertension therapies in patients with diabetes. J Am Coll Cardiol. 2010;56:77-85. https://pubmed.ncbi.nlm.nih.gov/20620720Clinical Impact RatingsGIM/FP/GP: Cardiology: Endocrinology: Reference1 Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. The early termination of clinical trials: causes, consequences, and control. With special reference to trials in the field of arrhythmias and sudden death. Circulation. 1994;89:2892-907. [PMID: 8205706] Google Scholar Author, Article, and Disclosure InformationAuthors: Srinivas Merugu, MDAffiliations: St. Vincent Charity Medical Center, Cleveland, Ohio, USA (S.M.)This article was published at Annals.org on 5 October 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 October 2010Volume 153, Issue 8Page: JC4-2KeywordsCardiovascular therapyCoronary revascularizationHeartHospitalizationsHypertensionMortalityMyocardial infarctionResuscitationStrokeUnstable angina ePublished: 19 October 2010 Issue Published: 19 October 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Social services can act on anonymous information about abuse
Authors: J. Wynne
Journal: BMJ (1998)

The link between physical and sexual abuse was not well recognised 15 years ago. It is now known that about one sixth of physically abused children have also been sexually abused.1 When this child was admitted to hospital for investigation, had she been referred because of her parents' or general practitioner's concern? The admission gave staff an opportunity to observe her behaviour and her attachment to her parents. Why hadn't her parents noticed she was upset? Did she talk to the nurses? Did she have any genital symptoms such as soreness or dysuria? Did anyone ask the child why she had so many bruises? Probably not in 1980, but all these …
Gluteal Hematoma A Potential Cause for a False-positive Tc-99m RBC Gastrointestinal Bleeding Study
Authors: DARLENE FINK-BENNETT, JAMES R. JOHNSON
Journal: Clinical Nuclear Medicine (1984)

A 51-year-old white woman with abdominal pain and intermittent melanotic, guaiac positive stools had a Tc-99m RBC gastrointestinal bleeding study. On the 6-hour anterior scintiscan a focal area of increased accumulation of radiotracer was noted within the region of the left superior iliac crest. Its lateral location mitigated against it representing a colonic bleed. A 24-hour delayed scan confirmed this, as the extravasated Tc-99m-labeled red blood cells were found to be located within a 12 × 14-cm left gluteal subcutaneous hematoma.
Liver Scan in Hyperlipoproteinemia
Authors: Bernard A. Sachs, Philip A. Bardfeld, Jerome E. Bodian, Leroy A. Sugarman, Leon Hellman
Journal: JAMA (1974)

Liver scans with technetium 99m sulfur colloid were obtained in 48 subjects with hyperlipoproteinemia who were being treated with various lipidlowering drug regimens or were receiving no therapy. Twenty-seven of the 48 liver scans were abnormal, but the abnormalities could not be firmly attributed to a specific lipoprotein phenotype or treatment regimen. Of the patients with elevated triglyceride levels, 71% had abnormal liver scans. Hypertriglyceridemia was present in 55% of the subjects with abnormal liver scans compared to 28% of the subjects in whom the scans were normal. Hyperlipoproteinemia should be considered as a possible associated factor in evaluating an abnormal liver scan.
Levamisole toxicity mimicking autoimmune disease
Authors: Lauren Strazzula, Katherine K. Brown, Joaquin C. Brieva, Brendan J. Camp, Hillary C. Frankel, Eugene Kissin, Matthew J. Mahlberg, Mary Alice Mina, Miriam K. Pomeranz, Isaac Brownell, Daniela Kroshinsky
Journal: Journal of the American Academy of Dermatology (2013)
Monoclonal Antibodies Against Human Breast Tumor-Associated Antigens: Characterization of B21 Antigen
Authors: N. V. Annibali, J. A. S. Martino, A. Baldi
Journal: JNCI Journal of the National Cancer Institute (1994)

Monoclonal antibodies (MAbs) show Promise in the early detection and monitoring of cancer and may have therapeutic applications as well. The purpose of this study was to characterize MAb B21, a novel murine-derived antibody that has strong reactivity with MCF-7 and T47D cell lines from human breast cancer. A number of MAbs that react with breast cancer cell lines were obtained from cultured mouse spleen cells, and one, MAb B21, was selected for detailed analysis. MAb B21 was characterized by immunocytochemical, immunofluorescence, immuno-precipitation, and Western blotting procedures. We found a strong reactivity of MAb B21 with cultured breast cancer cells and cells from human breast tumors, although some reactivity was seen sporadically in non-breast or normal tissue. Negligible reactivity was detected in a series of non-breast cell lines and with normal breast epithelial cell line MCF-10A. However, when MCF-10A Cells were permeabilized, allowing the antibody to penetrate within the cells, reaction became apparent. MCF-10A cells, When transfected with the oncogene c-Ha-ras (MCF-10T), gave a positive immunostaining similar to that observed with MCF-7 and T47D cells. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of L-[ 35 S]methionine-labeled MCF-7 and T47D cell extracts showed distinct immunoprecipitated components, with molecular weight values ranging from 150000 to 20000 with the addition of MAb B21. Western blot assays using MAb B21 of SDS-PAGE fractionated/electroblotted proteins from breast cancer cell lines and MCF-10A cells showed specific reaction with a 95000 component. Our results indicate that B21 antigen is expressed in neoplastic cells of epithelial origin, mainly breast cancer, and to a minor extent in other cell lines. In addition, MAb B21 recognizes an antigen that is differentially localized during cell transformation. Our future studies will address the full characterization of MAb B21 and explore its capacity as a tool for therapeutic manipulation. [J Natl Cancer Inst 86:215–221, 1994]
Words About Words
Authors: Hugh H. Hussey
Journal: JAMA (1975)

Some readers of the editorial, "A Word Fitly Spoken" (230:1436, 1974), were compelled to comment. For example, Hobart A. Reimann, MD, of Philadelphia, wrote: I enjoyed reading your editorial about words. I have always used words other than "marked," "markedly" and "parameter." You could have included "dramatic." The patient made a dramatic recovery, etc. I also object to "the patient was<i>put on or taken off</i>digitalis." On rounds, I usually turn the patient over to look. On two occasions students reciting a patient's record stated, "I did a urine on him"! Most copy editors split my unsplit adverbial phrases. Henry Christian was a stickler in the matter, and always corrected my lapses. In the quotation from Proverbs, would it not have been better to say "<i>Words</i>fitly spoken<i>are</i>like apples...."? But who am I to question biblical language? Another reader of the earlier editorial took issue with an
Congenital anomaly of pancreas divisum as cause of obstructive pain and pancreatitis.
Authors: P B Cotton
Journal: Gut (1980)

Pancreas divisum occurs when the embryological ventral and dorsal parts of the pancreas fail to fuse, so that pancreatic drainage is mainly through the accessory papilla. In 169 patients with primary biliary tract disease who underwent pancreatography incidental to endoscopic cholangiography, the incidence of pancreas divisum was 3.6%. Among 78 patients with unexplained recurrent pancreatitis, the incidence was 25.6%. The hypothesis that the duct anomaly can cause obstructive pain and pancreatitis is presented, and supported by a detailed analysis of 47 patients with the condition.
PROSPECTIVE CONTROLLED TRIAL OF INJECTION SCLEROTHERAPY IN PATIENTS WITH CIRRHOSIS AND RECENT VARICEAL HÆMORRHAGE
Authors: A.W. Clark, D. Westaby, D.B.A. Silk, J.L. Dawson, B.R.D. Macdougall, K.J. Mitchell, L. Strunin, Roger Williams
Journal: The Lancet (1980)
Prognosis of Transient Neurological Attacks—Reply
Authors: Michiel J. Bos
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Epileptischen Erkrankungen. Ihre Anatomischen und Physiologischen Unterlagen sowie Ihre Chirurgische Behandlung. By Prof. Fedor Krause und Dr. Heinrich Schum.(<i>I Hälfte. Neue Deutsche Chirurgie, von Ferdinand Enke, Stuttgart, 1931.</i>)
Authors: J. Notkin
Journal: American Journal of Psychiatry (1932)
Occupational Lung Diseases
Authors: Elihu A. Channin
Journal: JAMA (1975)

It is refreshing to find a medical text that blends scientific information, historical background, and enlightened opinion into a simple pleasant style. This is an enjoyable book to read. In a consistently logical and skillful way the authors give the background information necessary to understand the pulmonary pathophysiology. First, there is a straightforward presentation of pulmonary physiology, followed by the physics of dust deposition and epidemiologic methods. Next is an excellent presentation of the ways in which the lung can react to injury. A separate chapter reviews the types of immunologic reactions. Silicosis, asbestosis, and coal workers' pneumoconiosis account for one third of the total of this volume, and these subjects are dealt with masterfully and comprehensively. These three chapters alone contain 303 references.  No less important are the chapters devoted to the inhalation of other minerals, the occupational asthmas and allergic alveolitis, industrial bronchitis, byssinosis, and the inhalation of
On the design and function of rational arguments
Authors: John E. Opfer, Vladimir Sloutsky
Journal: Behavioral and Brain Sciences (2011)

Abstract It is unclear how an argumentative environment would select for better reasoning given three general findings. First, argument rationality typically fails to persuade poor reasoners. Second, reasoned argumentation competes with more persuasive and less rational arguments for limited cognitive resources. Third, those poor at reasoning fail to distinguish between valid and invalid arguments. Reasoning, therefore, is poorly designed for argument.
Antegrade slow bypass conduction after closed-chest ablation of the His bundle in permanent junctional reciprocating tachycardia.
Authors: G Critelli, F Perticone, F Coltorti, V Monda, J J Gallagher
Journal: Circulation (1983)

A case of permanent junctional reciprocating tachycardia in a 36-year-old woman successfully treated with closed-chest interruption of the His bundle is reported. Tachycardia had lasted for 14 years and showed a retrograde P wave (P') and RP' longer than PR' interval. The tachycardia used an anomalous pathway with a long conduction time in the retrograde direction. The atrial end of the anomalous pathway was located near the coronary sinus orifice. His ablation was accomplished by delivering a direct-current shock from a cardioversion unit to the nodal-His zone by means of a conventional electrode catheter percutaneously introduced via the femoral vein. Two shocks were necessary to obtain the desired results. After the procedure, complete atrioventricular block below the His bundle was induced, while antegrade conduction was assured through the anomalous pathway that showed decremental properties. During 7 months of follow-up, stable sinus rhythm with a long PR interval has been observed; the patient has remained free from tachycardia. Furthermore, she is not pacemaker-dependent and requires no cardioactive medication. This case demonstrates the therapeutic value of closed-chest ablation of the His bundle in a patient with permanent junctional reciprocating tachycardia, as well as demonstrating for the first time that the underlying accessory pathway is capable, in some instances, of antegrade conduction.
Loss of Heterozygosity Mutations of Tumor Suppressor Genes in Cytologically Atypical Areas in Chronic Lymphocytic Thyroiditis
Authors: Jennifer L. Hunt, Zubair W. Baloch, E. Leon Barnes, Patricia A. Swalsky, Cindy L. Trusky, E. Sasatomi, Sydney Finkelstein, Virginia A. LiVolsi
Journal: Endocrine Pathology (2002)
Possible relation of p53 and mdm-2 oncoprotein expression in thyroid carcinoma: A molecular-pathological and immunohistochemical study on paraffin-embedded tissue
Authors: Kurt W. Schmid, Agnes Bankfalvi, Swantja Mücke, Dietmar Öfner, Kristina Riehemann, Sören Schröder, Andrea Stücker, Martin Tötsch, Barbara Dockhorn-Dworniczak
Journal: Endocrine Pathology (1996)
THE INFLUENCE OF SULFONAMIDE THERAPY ON POSTPNEUMONIC EMPYEMA THORACIS
Authors: THOMAS H. BURFORD
Journal: JAMA (1942)

The dramatic beneficial effects of the sulfonamide derivatives in the treatment of pneumonia has naturally invited investigations concerning the effects of these drugs on empyema thoracis. There was even some hope that chemotherapy might largely eliminate the necessity of surgical intervention in cases of empyema by causing the disappearance of pus resulting from infections by organisms vulnerable to the sulfonamide derivatives. There is now, however, sufficient experience with postpneumonic empyemas in patients who had received adequate chemotherapy during the course of the pneumonia to state categorically that, once empyema thoracis (an abscess in the pleura) is present, adequate drainage of the abscess is essential. It becomes apparent, therefore, that the introduction of the sulfonamide derivatives has not altered in any way the fundamental principles of the management of empyema which were outlined by Graham and Bell 1 during the first world war. To add to the voluminous and exhaustive literature
Orthopaedic surgery: a health hazard.
Authors: J. J. Dias, I. J. Brenkel, S. G. Tordoff
Journal: BMJ (1988)

One of us had a friend who was a shepherd in Gower.This shepherd had raised sheep for over 50 years and knew their gestational habits well.He used to claim that they rarely lambed at the time of the ebb tide but generally gave birth during the time of the flood.Most of Gower is close to the sea, and the times of high tides z Sheep on headland, Rhossili, Gower were well known to shepherds and everyone else living there, for much depended on them.To test whether this phenomenon occurred in women we studied the population delivering at this hospital over two months, covering two lunar tidal cycles.
638 IFN-α TREATMENT OF HEPATITIS B VIRUS (HBV)-INFECTED PRIMARY HUMAN HEPATOCYTES LEADS TO A SPECIFIC REDUCTION OF HBV MRNA LEVELS
Authors: J. Zhang, J. Köck, H.E. Blum, M. Nassal, J. Rasenack, T. Baumert, C. Thoma
Journal: Journal of Hepatology (2010)
The 18 kDa peanut oleosin is a candidate allergen for IgE‐mediated reactions to peanuts
Authors: L. Pons, C. Chery, A. Romano, F. Namour, M. C. Artesani, J.‐L. Guéant
Journal: Allergy (2002)

Background : Peanut allergy is one of the five most frequent food allergies in children and in adults. Recently, we purified and evaluated the allergenicity of peanut oleosins, a family of small‐sized proteins involved in the formation of peanut oil bodies. Methods: Allergenicity of the purified native protein and of the recombinant protein was tested by Western blot and by IgE‐RIA. Results: We found IgE‐binding with oleosin in 3 of 14 sera of patients who had suffered an allergic reaction to peanuts. Two sera reacted weakly against 16–18 kDa proteins corresponding to oleosin monomers, in Western blot. The main reacting bands had a molecular size estimated at ≈34 kDa, ≈50 kDa and ≈ 68 kDa and could therefore correspond to oleosin oligomers. IgE reactivity was higher in extracts from roasted peanuts. The same phenomenon occurred with crude soybean oil fraction, with two bands of 16.5 and 24 kDa corresponding to monomers, and two bands of 50 kDa and 76 kDa corresponding to dimers and trimers, respectively. The 18 kDa band was observed in the 3 Western blots of a membrane‐enriched fraction of recombinant oleosin produced in the Sf 9‐baculovirus expression system (performed with the 3 patient sera). Conclusions: We have characterized a new peanut allergen which belongs to the oleosins, a family of proteins involved in the formation of oil bodies. The protein may be involved in some of the allergic cross‐reactions to peanuts and soybeans.
Quantitative Angiocardiography
Authors: J. WARD KENNEDY, R. D. TWISS, J. R. BLACKMON, H. T. DODGE
Journal: Circulation (1968)

Quantitative angiocardiographic techniques have been used to determine left ventricular volume and mass in 100 patients with isolated aortic valve disease. The patients were divided into three groups: aortic stenosis (AS), 22 patients; aortic regurgitation (AR), 38 patients; and combined stenosis and regurgitation (AS+AR), 40 patients. The distribution of left ventricular volume and mass and their relationship to standard intracardiac pressure and flow determinations are presented for each group in order to define the hemodynamic and functional characteristics of the left ventricle in these patients. Mean values for end-diastolic volumes (EDV) in the three groups were AS=85 ml/m 2 , AS+AR=143 ml/m 2 and AR=197 ml/m 2 . Mean values for ejection fraction (EF=SV/EDV) were similar in the three groups, AS=61%, AR= 55%, AS+AR=58%. Left ventricular mass (LVM) was smaller in AS, mean=167 g/m 2 , and similar in AR, mean=232 g/m 2 , and AS+AR, mean=235 g/m 2 . Left ventricular filling pressure (LVEDP) was correlated with EDV in AS, r=0.45, P &lt;0.05, and AS+AR, r=0.51, P &lt;0.001, but not in AR. A similar relationship was seen between LVEDP and EF. The arteriovenous oxygen difference correlated well with EF in AS, r=–0.76. P &lt;0.001. This relationship was weaker in AS+AR, r= –0.45, P &lt;0.01, and AR, r=–0.45, P &lt;0.01. Correlations were also present between increased LVM and elevated LVEDP and increased LVM and decreased EF in patients with AS and AS+AR.
Yaa Opokua Antwi-Yeboah
Authors: Edward Osei
Journal: BMJ (2004)

Former senior house officer Glasgow (b Ghana 1978; q Dundee 2002), died from a pulmonary embolism on 21 September 2004.​2004.




Figure 1




Yaa came to the United Kingdom from Ghana at the age of 2, when her father immigrated to pursue his postgraduate education in obstetrics and gynaecology. Before her death, she worked as a senior house officer in anaesthesia at Southern General Hospital in Glasgow. She leaves her parents, her twin brother, and two sisters.
Liver toxicity of sitaxentan in pulmonary arterial hypertension
Authors: Nazzareno Galiè, Marius M Hoeper, J Simon, R Gibbs, Gerald Simonneau
Journal: European Respiratory Journal (2011)

To the Editors:

Ambrisentan, bosentan and sitaxentan are endothelin receptor antagonist (ERA) drugs approved for the treatment of patients with pulmonary arterial hypertension (PAH) and are included in the treatment algorithm of the 2009 pulmonary hypertension (PH) guidelines of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS) 1.

Hepatotoxicity is a frequent side-effect of ERA therapy, which is contra-indicated in patients with mild to severe hepatic impairment (Child–Pugh class B–C) and elevated serum aminotransferases prior to initiation of treatment. In addition, liver function testing on a monthly basis is recommended in PAH patients treated with these compounds, in order to detect an increase in the serum aminotransferases 1. In most cases, liver injury is dose-related and reversible with dose reduction or drug discontinuation, suggesting that hepatotoxicity is caused by a dose-dependent toxic effect. The exact mechanisms by which …
Burn hazard with cement.
Authors: M W Flowers
Journal: BMJ (1978)

aware of the possibility of this injury, we believe that patients should be strongly advised to wear seat belts, properly fitted in compliance with the manufacturer's instructions.This case report in no way detracts from the value of the seat belt but tends to support the view that major injury will be minimised in this type of dangerous accident.We present this case to indicate another variant of the seat belt injury syndrome and in accordance with the suggestion that such injuries should be recorded to assess the magnitude of the problem.We thank Mr J H Balmer for permission to report this case and Miss Hilary Cromie for typing the manuscript.ADDENDUM-Since this report was written this patient was seen again at another hospital with total avulsion of his ileostomy as the result of direct trauma during a brawl.The ileostomy was satisfactorily revised, and his postoperative course was uncomplicated.
Patients' perception of involuntary weight loss: implications of underestimation and overestimation.
Authors: C Ramboer, M Verhamme, L Vermeire
Journal: BMJ (1985)

possibility of a detectable beneficial or harmful effect on survival.The number of patients randomised within the groups with positive nodes at first were large enough for any difference in survival to have been apparent in an analysis.Hence any possibly harmful effect must be small or it would have been detected.