tbuckley/cabot-search huggingface dataset:
THE ETIOLOGY OF CHOROIDITIS.
Authors: C. DREW
Journal: JAMA (1905)

The following observations regarding the causal relations of choroiditis with rubeola are the results of observations of numerous cases of this disease which have come under my observation. It has always seemed to the writer that the pathology of choroiditis has not been so definitely established or defined as to enable the practitioner to feel that he has at his command any remedy on which he can rely with definite expectation as to good results, and, in the majority of cases treated, the result has been either partial improvement, a negative result, or gradual loss of vision. In standard works on ophthalmology, the following causes of choroiditis are mentioned: eruptive diseases, syphilis, rheumatism, dysentery, meningitis, thrombosis, and infection by pyogenic organisms; the three last named causes are probably sequelæ of other diseases. Exposure to light is also mentioned as a cause, to which may be added traumatism. The following case
A GRAPHIC COMPARISON OF FIVE PHENOTHIAZINES
Authors: JACKSON A. SMITH, DOROTHY CHRISTIAN, ELAINE MANSFIELD, ALFREDO FIGAREDO
Journal: American Journal of Psychiatry (1959)

Five phenothiazine derivatives have been studied using similar groups of patients and similar methods of evaluating and recording behavioral change. All of the patients included in these reports had been hospitalized longer than one year and had been refractory to previous treatment efforts. The results indicate that this group of chronic patients, all but 3 of whom were schizophrenic, were no more responsive to these compounds than to treatment procedures earlier tried. The graphing of the data simplifies the comparison of compounds evaluated under similar conditions. Improvement occurred so infrequently in these screening procedures that a controlled or "double-blind" study did not appear necessary.
On Peripheral Neuritis
Authors: J. Ross
Journal: BMJ (1887)

THE W-ubject of this dliscussion, which I have been asked to open, is " Periplheral Neuritis."Dy neuritis is, of course, meant inflammation of nerves, and by the qualifying term, "peripheral," I presume it is inteuded to limit the discussion to disease in the course of the nerves after they have passed beyond the intervertebral and cranial foramina.The subject, as thus definedl, is so wide, that I will take it upon myself to limit the discussion still further.It would hardly lead to any profit.able result were we, at one sitting, to take into our consideration the phenomena which attend inflammation of individual nerves, iricluding sensory, motor, and mixed nerves, and the nerves of special sense.It seems to me, therefore, desirable to restrict the field of our discussion to that very important group of inflammation of nerves in which a larger and larger nuLmber of the trunks are successively invaded, the disease beginning at the periphery and extending towards the centre.This disease, variously called progressive multiple neuritis, polyneu--c-itis multiplex, and other names, invades the body as a rule in a sym- -metrical manner as regards the two sides, although the phenomena may bq more pronounced ou one side than on the other.Nowv this is one of the chief characterisitics of those (liscases that are caused by a poison circulating in the blood, and there can be no doubt whatever, that in at least the majoiity of cases, this affection is caused by a poisonl.The best known disease of this group is probably lead paralysis, and there is no room for dloiibt that it, at any rate, is caused, directly or -indirectly, by the introdclation into the system of a poison from with- out.It is also known that arsenic, and probably copper and other metallic salts, give rise to a paralysis of the same general type as leadkparalysis.T,i: .eocondvarietv of this disease is typified by the paralysis which results iom alcoholiob excess.In this variety may be included the paraiysis caused by the iumes of bisulphide and oxide of carbon, and probably also, the severe pains in the limbs caused by the abuse of -chloroform and chloral.The same type of paralysis has also been met wit"h in advanced cases of diabetes.The third variety of this affection results froin animal poisons, ancl of these diphtheritic paralysis is pro- hal31v tlhe best known.The remaarkable cases of universal paralysis £i'te ied by Dr. Buzzard, as occurring in syphilitic subjects, is now ac' elcwlegedl by himn to belong, to the group of peripheral neuritis, and LIuese niay be placed in the samie class as diphtheritic paralysis.
Comparative evaluation of the IBM (12-lead) and Royal Infirmary (orthogonal three-lead) ECG computer programs.
Authors: P W Macfarlane, D I Melville, M R Horton, J J Bailey
Journal: Circulation (1981)

A comparison of two computer programs for ECG interpretation was undertaken. Twelve-lead ECGs from 300 patients with various clinical abnormalities were interpreted at the National Institutes of Health using version 1 of the IBM program and corresponding orthogonal three-lead ECGs were analyzed by the Glasgow Royal Infirmary (GRI) program. Interpretations were compared with respect to the clinical documentation, wherever possible, and with each other directly in the case of diagnostic statements for which non-ECG documentation was not available. The two programs had a similar performance in determining abnormalities such as myocardial infarction and ventricular hypertrophy. However, with respect to conduction defects and ST-T-wave statements, certain discrepancies between the two program performances were revealed. There were 222 disagreements between various diagnostic statements. GRI was judged correct in 119 of these disagreements and IBM in 70. In these 189 cases the disagreement could most often be accounted for by different criteria and/or algorithms in the two programs or by the use of different ECG lead sets. The remaining 33 disagreements had to be classified as inconclusive.
Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes
Authors: Fiona F. O'Connor, Denis C. Shields, Anthony Fitzgerald, Christopher P. Cannon, Eugene Braunwald, Desmond J. Fitzgerald
Journal: Blood (2001)
The American College of Physicians Award Lecture: Possible Medical Significance of Dynamic Events in Cells.
Authors: Charles Philippe LeBlond
Journal: Annals of Internal Medicine (1966)

s1 May 1966The American College of Physicians Award Lecture: Possible Medical Significance of Dynamic Events in Cells.Charles Philippe LeBlond, M.D., Ph.D.Charles Philippe LeBlond, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1173_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRadioautography has demonstrated the existence of considerable synthetic activity in cells. After administration of labeled nucleosides it is possible to show continuous synthesis of nucleic acid (RNA) in the nucleus of most cells, followed by migration to cytoplasm. With labeled amino acids, it may be seen that there is continuous synthesis of protein in all cells, both in nucleus and cytoplasm where the synthesis occurs in relation to ribosomes. Recently, after injection of labeled glucose or galactose, continuous synthesis of complex carbohydrates, such as glycoprotein, has been observed in the Golgi region of many cells.Knowledge of these phenomena is... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal, Quebec, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1173-1174KeywordsCarbohydratesCellsCytoplasmGlucoseGlycoproteinsNucleic acidsNucleosidesProtein synthesisRNARibosomes Issue Published: 1 May 1966 PDF DownloadLoading ...
Anaphylaxis From Tolmetin
Authors: Carl Restivo
Journal: JAMA (1978)

TOLMETIN SODIUM (Tolectin) is one of the newer nonsteroidal anti-inflammatory agents used in the management of rheumatoid arthritis. The package insert accompanying tolmetin includes many adverse effects of the drug, but there is no mention of anaphylactic shock induced by this agent. This report describes two patients in whom anaphylactic shock developed within 15 minutes of ingesting two 200-mg tolmetin sodium tablets. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 43-year-old woman was admitted to University of California at Los Angeles Hospital for anaphylactic shock. She had a three-year history of rheumatoid arthritis functional class 2, and met the American Rheumatism Association classification for definite rheumatoid arthritis. Previously, she had been treated with phenylbutazone. Gold sodium thiomalate therapy had been discontinued one year before admission because of severe generalized toxic dermatitis after a total of 260 mg had been given. Six months before admission, a facial rash had developed while taking 500
STUDIES ON NEOPLASMS WITH THE AID OF RADIOACTIVE PHOSPHORUS. III. THE PHOSPHORUS METABOLISM OF THE PHOSPHOLIPID, ACID SOLUBLE AND NUCLEOPROTEIN FRACTIONS OF VARIOUS TISSUES OF NORMAL AND LEUKEMIC MICE FOLLOWING THE ADMINISTRATION OF “TRACER” AND “THERAPEUTIC” DOSES OF RADIO-PHOSPHORUS1
Authors: L. W. Tuttle, L. A. Erf, John H. Lawrence
Journal: Journal of Clinical Investigation (1941)
THE ASSOCIATION OF A3872G POLYMORPHISM ON C-REACTIVE PROTEIN WITH PERIPHERAL ARTERIAL DISEASE AND WAIST HIP RATIO INDEX IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Stavroula Papaoikonomou, Dimitris Tousoulis, Nicholas Tentolouris, Dimitris Papadogiannis, Antigoni Miliou, Nikolaos Papageorgiou, George Hatzis, Emmanuel Androulakis, Charalambos Antoniades, Christodoulos I Stefanadis
Journal: Journal of the American College of Cardiology (2014)
RACIAL DIFFERENCES IN THE PREVALENCE OF UNCONTROLLED AND UNREPORTED HYPERTENSION IN THE SOUTHEASTERN UNITED STATES: INSIGHTS FROM ALMOST 70,000 BLACKS AND WHITES IN THE SOUTHERN COMMUNITY COHORT STUDY
Authors: Uchechukwu K.A. Sampson, Todd L. Edwards, Eiman Jahangir, Heather Munro, Minaba Wariboko, Mariam G. Wassef, Sergio Fazio, George A. Mensah, Edmond K. Kabagambe, William J. Blot, Loren Lipworth
Journal: Journal of the American College of Cardiology (2013)
Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation
Authors: Masato Suzuki, Hitomi Mimuro, Kotaro Kiga, Makoto Fukumatsu, Nozomi Ishijima, Hanako Morikawa, Shigenori Nagai, Shigeo Koyasu, Robert H. Gilman, Dangeruta Kersulyte, Douglas E. Berg, Chihiro Sasakawa
Journal: Cell Host & Microbe (2009)
Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells.
Authors: F A Gesek, P A Friedman
Journal: Journal of Clinical Investigation (1992)

Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on immortalized mouse distal convoluted tubule (MDCT) cells to determine the mechanism underlying the dissociation of sodium from calcium transport and the stimulation of calcium absorption induced by thiazide diuretics. Control rates of 22Na+ uptake averaged 272 +/- 35 nmol min-1 mg protein-1 and were inhibited 40% by chlorothiazide (CTZ, 10(-4) M). Control rates of 36Cl- uptake averaged 340 +/- 50 nmol min-1 mg protein-1 and were inhibited 50% by CTZ. CTZ stimulated 45Ca2+ uptake by 45% from resting levels of 2.86 +/- 0.26 nmol min-1 mg protein-1. Bumetanide (10(-4) M) had no effect on 22Na+, 36Cl-, or 45Ca2+ uptake. Control levels of intracellular calcium activity ([Ca2+]i) averaged 91 +/- 12 nM. CTZ elicited concentration-dependent increases of [Ca2+]i to a maximum of 654 +/- 31 nM at 10(-4) M. CTZ reduced intracellular chloride activity ([Cl-]i), as determined with the chloride-sensitive fluorescent dye 6-methoxy-N-(3-sulfopropyl)quinolinium. The chloride channel blocker 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB, 10(-5) M) abolished the effect of CTZ on [Cl-]i. NPPB also blocked CTZ-induced increases of 45Ca2+. Resting membrane voltage, measured in cells loaded with the potential-sensitive dye 3,3'-dihexyloxacarbocyanine iodide [DiOC6(3)], averaged -72 +/- 2 mV. CTZ hyperpolarized cells in a concentration-dependent and reversible manner. At 10(-4) M, CTZ hyperpolarized MDCT cells by 20.4 +/- 7.2 mV. Reduction of extracellular Cl- or addition of NPPB abolished CTZ-induced hyperpolarization. Direct membrane hyperpolarization increased 45Ca2+ uptake whereas depolarization inhibited 45Ca2+ uptake. CTZ-stimulated 45Ca2+ uptake was inhibited by the Ca2+ channel blocker nifedipine (10(-5) M). We conclude that thiazide diuretics block cellular chloride entry mediated by apical membrane NaCl cotransport. Intracellular chloride, which under control conditions is above its equilibrium value, exits the cell through NPPB-sensitive chloride channels. This decrease of intracellular chloride hyperpolarizes MDCT cells and stimulates Ca2+ entry by apical membrane, dihydropyridine-sensitive Ca2+ channels.
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage
Authors: André Cohnen, Samuel C. Chiang, Ana Stojanovic, Hendrik Schmidt, Maren Claus, Paul Saftig, Ottmar Janßen, Adelheid Cerwenka, Yenan T. Bryceson, Carsten Watzl
Journal: Blood (2013)
Parking the issue
Authors: K. Patel
Journal: BMJ (2013)

I was in the United States recently, driving along local roads the size of UK motorways. A road sign indicated an approaching hospital, and I turned to catch a glimpse of its buildings.

They could have been of any suburban hospital in any developed country—a mix of concrete, steel, and glass. One difference was striking, however: a sign underneath the usual directions for the emergency room and maternity department advertised valet parking.

Imagine that! Valet parking—not at a Michelin starred restaurant or five star hotel—but at a hospital. It seems ridiculous, doesn’t it?

Perhaps …
Alistair Burns and 51 colleagues reply to David Le Couteur and colleagues
Authors: A. Burns
Journal: BMJ (2013)

In their article, “Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis,”1 Le Couteur and colleagues contribute to the BMJ ’s “Too Much Medicine” campaign and attempt to repudiate three decades of dementia research and clinical practice. It completely misses the main aims of the current political approach and is in danger of affronting the millions of people with dementia and their families affected by this devastating illness, and of undoing much of the good done over recent years.

The impact of dementia is unique. It affects an estimated 36 million people worldwide, costs $600bn (£376bn; €444bn),2 and attracts profound stigma, which demotivates people to come forward for assessment and contributes to less than half of people with …
Points from Letters: Larva Migrans
Authors: P. Elphick
Journal: BMJ (1971)

<h3>ABSTRACT</h3> The medial prefrontal cortex (mPFC) and the dorsomedial striatum (dmStr) are linked to working memory (WM) but how striatum-projecting mPFC neurons contribute to WM encoding, maintenance, or retrieval remains unclear. Here, we probed mPFC→dmStr pathway function in freely-moving mice during a T-maze alternation test of spatial WM. Fiber photometry of GCaMP6m-labeled mPFC→dmStr projection neurons revealed strongest activity during the delay period that requires WM maintenance. Demonstrating causality, optogenetic inhibition of mPFC→dmStr neurons only during the delay period impaired performance. Conversely, enhancing mPFC→dmStr pathway activity—via pharmacological suppression of HCN1 or by optogenetic activation during the delay— alleviated WM impairment induced by NMDA receptor blockade. Consistently, cellular-resolution miniscope imaging resolved preferred activation of &gt;50% mPFC→dmStr neurons during WM maintenance. This subpopulation was distinct from neurons showing preference for encoding and retrieval. In all periods, including the delay, neuronal sequences were evident. Striatum-projecting mPFC neurons thus critically contribute to spatial WM maintenance.
Alterations in the Release of Norepinephrine at the Vascular Neuroeffector Junction in Hypertension
Authors: T C Westfall, M J Meldrum
Journal: The Annual Review of Pharmacology and Toxicology (1985)

Alterations in the Release of Norepinephrine at the Vascular Neuroeffector Junction in Hypertension, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/pharmtox/25/1/annurev.pa.25.040185.003201-1.gif
The Manchester Royal Infirmary Programmed Investigation Unit.
Authors: D Longson, B Young
Journal: BMJ (1973)

The Programmed Investigation Unit (P.I.U.) of the Man chester Royal Irifirrnary is an inpatient department providing facilities for all tests used in medicine. There are two special features of the unit: the timing of the admission of patients to suit their convenience; and placing of the tests in a compatible rapid sequence, which is incorporated in a timetable agreed with the investigative departments. This is an alternative to the usual pattern of waiting-list management, in which the availability of beds is the sole determinant of the admission date. In this traditional pattern investigations are usually requested after admission, and sometimes their full compass or the main purpose may not be fully grasped by the house staff until the next formal ward round. The investigations are then subjected to delays because of poor communications within the hospital and of the difficulties in the departments themselves. For the cold medical case admitted for investigation and diagnosis, the actual time spent by the patient in active investigations is surprisingly short in relation to the total duration of hospital admission. The proper use of hospital facilities and the convenience of patients demand that some attempt should be made to time admissions more carefully. This article describes a solution of the problem, which is characterized by a novel and advanced use of nursing skills and based on three assumptions which have been proved in practice. Firstly, the first generation of investiga tions can be predicted after the initial outpatient consultation and screening procedures. Secondly, in most cases, the first
HYPERCALCEMIA IN ACUTE RENAL FAILURE
Authors: H H Gossmann, H Lange
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 December 1968HYPERCALCEMIA IN ACUTE RENAL FAILUREH. H. GOSSMANN, H. LANGEH. H. GOSSMANNSearch for more papers by this author, H. LANGESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-6-1332_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We read with great interest the paper of Segal, Miller, and Moses on hypercalcemia during the diuretic phase of acute renal failure (Ann. Intern. Med. 68: 1066, 1968). Recently (June 1968) we have been concerned with the same problem:Our patient, a farmer aged 38, developed acute renal failure due to severe soft tissue injury after a road accident. During the anuric phase he had been hypocalcemic (7.2 mg/100 ml), and on the eleventh day of polyuria he was found to be normocalcemic (9.7 mg/100 ml), on the fourteenth day of the diuretic phase, however, hypercalcemia developed.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcute Renal FailureHeat stroke and related heat stress disordersXenobiotic-Induced RhabdomyolysisDépôts calciques musculaires au cours d'une rhabdomyolyse alcoolique aiguë avec insuffisance rénaleAcute drug-associated rhabdomyolysis: an examination of its diverse renal manifestations and complicationsResolution of Muscle Calcification in Rhabdomyolysis and Acute Renal FailureMOHAMMAD AKMAL, M.D., DAVID A. GOLDSTEIN, M.D., NANCY TELFER, M.D., EVELYN WILKINSON, M.D., SHAUL G. MASSRY, M.D.Myoglobin: Methods and Diagnostic UsesTransient hypercalcaemia following acute renal failure.Acute Renal Failure Due to Nontraumatic RhabdomyolysisALAN KOFFLER, M.D., ROBERT M. FRIEDLER, M.D., SHAUL G. MASSRY, M.D., F.A.C.P.Hypercalcemia of acute renal failureNontraumatic Rhabdomyolysis and Acute Renal FailureAzotaemic renal osteodystrophyHypercalcemia in Diuretic Phase of Acute Renal FailureARTHUR LEONARD, M.D., ROBERT J. NELMS JR., M.D. 1 December 1968Volume 69, Issue 6Page: 1332-1332KeywordsAcute renal failureDiureticsHypercalcemiaSoft tissues Issue Published: 1 December 1968 PDF DownloadLoading ...
Treatment with anti-TGF-β antibody ameliorates chronic progressive nephritis by inhibiting Smad/TGF-β signaling
Authors: Hirotaka Fukasawa, Tatsuo Yamamoto, Hiroyuki Suzuki, Akashi Togawa, Naro Ohashi, Yoshihide Fujigaki, Chiharu Uchida, Michiko Aoki, Mareto Hosono, Masatoshi Kitagawa, Akira Hishida
Journal: Kidney International (2003)
Preventive effects of antiviral therapy on progression of chronic hepatitis C virus infection to liver cirrhosis and hepatocellular carcinoma in Taiwan
Authors: M.L. Yu, W.L. Chuang, C.Y. Dai, L.P. Lee, S.C. Chen, Z.Y. Lin, M.Y. Hsieh, L.Y. Wang, W.Y. Chang
Journal: Journal of Hepatology (2003)
Allergy to foods in patients monosensitized to Artemisia pollen
Authors: J. C. Garcia Ortiz, P. Cosmes Martin, A. Lopez-Asunsolo
Journal: Allergy (1996)

It is known that patients with pollinosis may display clinical characteristics caused by allergy to certain fruits and vegetables, but subjects allergic to Artemisia seem to show particularly peculiar characteristics. The clinical features of 84 patients with rhinitis, asthma, urticaria, and/or anaphylaxis whose inhalant allergy was exclusively to Artemisia vulgaris were studied and compared with a control group of 50 patients monosensitized to grass pollen. The mean age for the beginning of symptoms was 30.2 years, and this was higher than in the control group (P < 0.05). We found the main incidence to be in women (70.2%). Some 42.3% had family history of atopia, lower than in the control group (P < 0.05), while the prevalence of asthma and urticaria was significantly higher (P < 0.05). Food hypersensitivity was reported by 23 patients (27.3%) allergic to Artemisia. The foods responsible (with respective numbers of cases) were honey (14), sunflower seeds (11), camomile (four), pistachio (three), hazelnut (two), lettuce (two), pollen (two), beer (two), almond (one), peanut (one), other nuts (one), carrot (one), and apple (one). None of the patients monosensitized to grass had food allergy. CAP inhibition experiments were carried out on a single patient. Results showed the existence of common antigenic epitopes in pistachio and Artemisia pollen for this patient. We concluded that mugwort hay fever can be associated with the Compositae family of foods, but that it is not normally associated with other foods.
719 HCV-SPECIFIC CELLULAR IMMUNE RESPONSES (SCIR) IN HETEROSEXUAL PARTNERS OF PATIENTS WITH CHRONIC HEPATITIS C
Authors: J. Aguilar-Reina, M.C. Roque-Cuellar, M.A. Alvarez-Marquez, R. Garcia-Lozano, A. Nunez, M.F. Gonzalez-Escribano, B. Sanchez
Journal: Journal of Hepatology (2008)