tbuckley/cabot-search huggingface dataset:
Acute myocardial infarction in dogs with experimental diabetes
Authors: R. Forrat, L. Sebbag, N. Wiernsperger, J. Guidollet, S. Renaud, M. de Lorgeril
Journal: Cardiovascular Research (1993)

Journal Article Acute myocardial infarction in dogs with experimental diabetes Get access Rémi Forrat, Rémi Forrat INSERM Unit 63, 22 Avenue Doyen Lépine, 69500 Bron, France: R Forrat, L Sebbag, S Renaud, M de Lorgeril; Lipha Laboratories, Lyon, France: N Wiernsperger; Laboratory of Biochemistry, Hôpital Cardiologique, Bron, France: J Guidollet. Correspondence to Dr de Lorgeril. Search for other works by this author on: Oxford Academic PubMed Google Scholar Laurent Sebbag, Laurent Sebbag INSERM Unit 63, 22 Avenue Doyen Lépine, 69500 Bron, France: R Forrat, L Sebbag, S Renaud, M de Lorgeril; Lipha Laboratories, Lyon, France: N Wiernsperger; Laboratory of Biochemistry, Hôpital Cardiologique, Bron, France: J Guidollet. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nicolas Wiernsperger, Nicolas Wiernsperger INSERM Unit 63, 22 Avenue Doyen Lépine, 69500 Bron, France: R Forrat, L Sebbag, S Renaud, M de Lorgeril; Lipha Laboratories, Lyon, France: N Wiernsperger; Laboratory of Biochemistry, Hôpital Cardiologique, Bron, France: J Guidollet. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeannine Guidollet, Jeannine Guidollet INSERM Unit 63, 22 Avenue Doyen Lépine, 69500 Bron, France: R Forrat, L Sebbag, S Renaud, M de Lorgeril; Lipha Laboratories, Lyon, France: N Wiernsperger; Laboratory of Biochemistry, Hôpital Cardiologique, Bron, France: J Guidollet. Search for other works by this author on: Oxford Academic PubMed Google Scholar Serge Renaud, Serge Renaud INSERM Unit 63, 22 Avenue Doyen Lépine, 69500 Bron, France: R Forrat, L Sebbag, S Renaud, M de Lorgeril; Lipha Laboratories, Lyon, France: N Wiernsperger; Laboratory of Biochemistry, Hôpital Cardiologique, Bron, France: J Guidollet. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michel de Lorgeril Michel de Lorgeril INSERM Unit 63, 22 Avenue Doyen Lépine, 69500 Bron, France: R Forrat, L Sebbag, S Renaud, M de Lorgeril; Lipha Laboratories, Lyon, France: N Wiernsperger; Laboratory of Biochemistry, Hôpital Cardiologique, Bron, France: J Guidollet. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 11, November 1993, Pages 1908–1912, https://doi.org/10.1093/cvr/27.11.1908 Published: 01 November 1993 Article history Received: 09 March 1993 Accepted: 29 June 1993 Published: 01 November 1993
General-practitioner obstetrics.
Authors: A. P. Millar
Journal: BMJ (1968)

M.JoUu" was thought to be due to menstrual loss, and the patient has remained well.Case 2.-A woman aged 45 was admitted under the care of Dr. L. S. Illis on 3 January 1968 with a 24-year history of attacks of right occipital headache on the first or fifth day of menstrua- tion.For the first 12 hours of each headache she also noticed vomiting, photophobia, and neck stiffness.She had not had cyclical vomiting as a child, but one sister had migraine.She had heard no bruit, but had noticed the headache worsened with alcohol; she was not taking an oral contraceptive.General examination revealed no abnormality apart from a blood pressure of 180/90 mm.Hg; there were no cardiac murmurs.Bilateral carotid and orbital bruits were heard; the carotid bruits were abolished by carotid compression, but both orbital bruits remained.At one time a soft right occipital bruit was heard and did not disappear with carotid compression.The remainder of the neurological examination was normal.Relevant haematology was: Hb 9.2 g./100 ml., M.C.H.C. 29%, iron-deficiency changes on the film.E.E.G. showed some 14-16 c.p.s.activity symmetrically mixed with the alpha frequencies.Bilateral carotid and catheter right vertebral angiography were normal, and the day following this the right carotid and occipital bruits had disappeared.Six days after angiography both carotid bruits had disappeared and the orbital bruits were much fainter.The patient was discharged with Hb 8.7 g./100 ml.The anaemia in these patients was of less sudden onset than that in Dr. Gareeboo's patients.In Case 1 the regression of symptoms and signs after transfusion with subsequent good progress justified the decision not to undertake angiography.Case 2 demonstrated an alteration of bruits after angiography, although at the same time the haemoglobin fell (perhaps within the limits of experimental error).So bruits are rather labile signs, and we hope to study further their significance in neurological dis- orders.The differentiation of tinnitus in anaemia from a bruit heard by the patient should not normally be difficult.Tinnitus may occur in postural hypotension, and its nature will be known to many by personal experience; some patients with cranial bruits can describe exactly the same noise as that heard by the observer with his stethoscope, and can time it with the pulse.-Iam, etc.,
Psychological changes during a controlled trial of rehabilitation in chronic respiratory disability.
Authors: A Cockcroft, G Berry, E B Brown, C Exall
Journal: Thorax (1982)

Thirty-four men with chronic respiratory disability took part in a randomised, controlled trial of physical training. The control group also undertook exercise training after their control period. During the study measurements were made of exercise tolerance (12-minute walking distance) and the men completed two psychology questionnaires. Walking distance improved significantly more in the treatment group than in the control group. Both groups recorded scores suggesting psychological "improvement" and the changes in the two groups were not significantly different from each other. There were no consistent associations between the increase in walking distance and changes in psychological scores. Initial psychological scores were not useful in predicting changes in walking distance. The results suggest that the effect of treatment on walking distance was not psychological.
A NEW METHOD OF TREATMENT OF LEPROTIC INFECTION OF THE NASAL MUCOSA
Authors: F. G. Rose
Journal: BMJ (1929)

MEIA_ORAcerebri are those chiefly concerlned, anid a course of treat- ilent witlh extracts of these glands is suggested.-Violentexercise, excessive standing, alnd colnstipation should be avoided and attention to general hygiene counselled.Tlhe technical details in the foregoing paragraphs are written witlh tlho approval of Professor Sicard and Dr. Gauigier, to
SUCCESSFUL TEEATMENT OF GENERALIZED PUSTULAR PSORIASIS (von ZUMBUSCH) BY SYSTEMIC ANTIBIOTICS CONTROLLED BY BLOOD CULTURE
Authors: T. McFADYEN, ALAN LYELL
Journal: British Journal of Dermatology (1971)

Journal Article SUCCESSFUL TEEATMENT OF GENERALIZED PUSTULAR PSORIASIS (von ZUMBUSCH) BY SYSTEMIC ANTIBIOTICS CONTROLLED BY BLOOD CULTURE Get access T. McFADYEN, T. McFADYEN Department of Dermatology, Royal Infirmary, Glasgow C.4 Search for other works by this author on: Oxford Academic Google Scholar ALAN LYELL ALAN LYELL Department of Dermatology, Royal Infirmary, Glasgow C.4 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 3, 1 September 1971, Pages 274–276, https://doi.org/10.1111/j.1365-2133.1971.tb07231.x Published: 01 September 1971 Article history Accepted: 27 July 1971 Published: 01 September 1971
The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. VII. A PROPOSED SITE OF ACTION FOR ADENOSINE-3′,5′-CYCLIC MONOPHOSPHATE
Authors: Guy R. Brisson, Francine Malaisse-Lagae, Willy J. Malaisse
Journal: Journal of Clinical Investigation (1972)

Glucose-induced insulin release is thought to result from the following sequence of events in the beta cell: glucose metabolism leading to the production of a metabolic signal, net calcium uptake by the beta cell in response to the signal, and interaction between calcium and a microtubular-microfilamentous system, leading to emiocytosis of the secretory granules. Dibutyryl-cyclic AMP (db-cAMP) and theophylline are known to potentiate glucose-induced insulin release, their insulinotropic action being most marked at high glucose concentrations. Based on the above mentioned concepts, it was considered in the present experiments that the primary site of action of cAMP in the beta cell could correspond to either a facilitation of glucose metabolism, a modification of calcium distribution, or an interaction with the microtubular-microfilamentous system. The first of these hypotheses appeared unlikely because db-cAMP and theophylline, in sharp contrast with other agents known to affect glucose metabolism in the beta cell, did not modify glucose-induced calcium uptake by isolated islets incubated at high glucose concentrations. The last hypothesis also appeared unlikely since theophylline did not interfere with the deleterious effect of colchicine on the microtubular system, and since vincristine or colchicine did not differentially affect the respective insulinotropic action of glucose and theophylline. An effect of cAMP upon calcium distribution in the beta cell was suggested by the following findings. Whereas glucose and leucine were unable to promote insulin release in the absence of extracellular calcium, the addition of db-cAMP or theophylline to the calcium-depleted media partially restored theinsulinotropic action of glucose and leucine. Moreover, theophylline caused a dramatic increase in (45)Ca efflux from perifused islets, even in the absence of glucose. It is concluded that the insulinotropic action of cAMP could be due to a glucose-independent translocation of calcium within the beta cell, from an organelle-bound pool to a cytoplasmic pool of ionized calcium readily available for transport across the cell membrane.
Efficacy and Safety of AMG 317, an IL-4Ra Antagonist, in Atopic Asthmatic Subjects: A Randomized, Double-blind, Placebo-controlled Study
Authors: J. Corren, W. Busse, E. Meltzer, L. Mansfield, G. Bensch, Y. Chon, M. Dunn, H. Weng, S. Lin
Journal: Journal of Allergy and Clinical Immunology (2009)
Expression of<i>ras</i>Oncogene p21 in Prostate Cancer
Authors: Michael V. Viola, Frank Fromowitz, Sheila Oravez, Swati Deb, Gerald Finkel, Joel Lundy, Patricia Hand, Ann Thor, Jeffrey Schlom
Journal: New England Journal of Medicine (1986)

The major neoplastic transformation-inducing genes of human solid tumors are members of the ras oncogene family. We used an immunohistochemical assay to assess expression of both the unaltered and the mutated ras oncogene protein (p21) in normal and neoplastic prostatic cells. With the concentration of monoclonal antibody used in this study, epithelial and stromal cells from subjects with normal prostates and from 19 patients with benign prostatic hyperplasia were negative for p21 antigen. This antigen was detected in 2 of 6 prostates with Grade I carcinoma, 4 of 6 with Grade II, and all of 17 with higher grades. A semiquantitative immunohistochemical method demonstrated that expression of the p21 antigen in a carcinoma strongly correlated with nuclear anaplasia and was inversely related to the degree of glandular differentiation. However, markedly anaplastic tumors were often more heterogeneous in expression of p21 and contained areas of low staining for the antigen. Comparison of p21 antigen with tumor carcinoembryonic antigen and prostate-specific antigen demonstrated that ras p21 was the only phenotypic marker that correlated with histologic tumor grade. Thus, ras oncogene p21 may represent a new class of biologically relevant tumor markers and may be a useful adjunct to histopathologic examination in determining the prognosis of patients with prostate cancer.
α-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca2+- and PKC-dependent stimulation of cAMP
Authors: Gene D. LeSage, Domenico Alvaro, Shannon Glaser, Heather Francis, Luca Marucci, Tania Roskams, Jo Lynne Phinizy, Marco Marzioni, Antonio Benedetti, Silvia Taffetani, Barbara Barbaro, Giammarco Fava, Yoshiyuki Ueno, Gianfranco Alpini
Journal: Hepatology (2004)

Acetylcholine potentiates secretin-stimulated ductal secretion by Ca 2+ -calcineurin-mediated modulation of adenylyl cyclase. D2 dopaminergic receptor agonists inhibit secretin-stimulated ductal secretion via activation of protein kinase C (PKC)-γ. No information exists regarding the effect of adrenergic receptor agonists on ductal secretion in a model of cholestasis induced by bile duct ligation (BDL). We evaluated the expression of α-1A/1C, -1β and β-1 adrenergic receptors in liver sections and cholangiocytes from normal and BDL rats. We evaluated the effects of the α-1 and β-1 adrenergic receptor agonists (phenylephrine and dobutamine, respectively) on bile and bicarbonate secretion and cholangiocyte IP 3 and Ca 2+ levels in normal and BDL rats. We measured the effect of phenylephrine on lumen expansion in intrahepatic bile duct units (IBDUs) and cyclic adenosine monophosphate (cAMP) levels in cholangiocytes from BDL rats in the absence or presence of BAPTA/AM and Gö6976 (a PKC-α inhibitor). We evaluated if the effects of phenylephrine on ductal secretion were associated with translocation of PKC isoforms leading to increased protein kinase A activity. α-1 and β-1 adrenergic receptors were present mostly in the basolateral domain of cholangiocytes and, following BDL, their expression increased. Phenylephrine, but not dobutamine, increased secretin-stimulated choleresis in BDL rats. Phenylephrine did not alter basal but increased secretin-stimulated IBDU lumen expansion and cAMP levels, which were blocked by BAPTA/AM and Gö6976. Phenylephrine increased IP 3 and Ca 2+ levels and activated PKC-α and PKC-β-II. In conclusion , coordinated regulation of ductal secretion by secretin (through cAMP) and adrenergic receptor agonist activation (through Ca 2+ /PKC) induces maximal ductal bicarbonate secretion in liver diseases. ( Supplementary material for this article can be found on the Hepatology website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html). (Hepatology 2004;40:1116-1127))
Reply to Patrick H. Tuliao and Koon Ho Rha's Letter to the Editor re: James E. Thompson, Sam Egger, Maret Böhm, et al. Superior Quality of Life and Improved Surgical Margins Are Achievable with Robotic Radical Prostatectomy After a Long Learning Curve: A Prospective Single-surgeon Study of 1552 Consecutive Cases. Eur Urol 2014;65:521–31
Authors: James Edward Thompson, Sam Egger, Phillip D. Stricker
Journal: European Urology (2014)
Detection of Noncritical Coronary Stenosis at Rest Without Recourse to Exercise or Pharmacological Stress
Authors: Kevin Wei, Elizabeth Le, Ananda R. Jayaweera, Jian-Ping Bin, N. Craig Goodman, Sanjiv Kaul
Journal: Circulation (2002)

Background — Currently, the detection of noncritical coronary stenoses requires some form of stress. We hypothesized that these stenoses can be detected at rest without recourse to stress by assessing adaptive changes that occur distally in the microcirculation. Methods and Results — Phasic changes in myocardial video intensity (VI) were measured at rest with continuous high-mechanical-index (MI) contrast echocardiography in 15 open-chest dogs. Data were acquired at baseline and in the presence of different degrees of noncritical coronary stenosis. In 6 of these dogs, capillary blood volume was also measured at baseline using high-MI intermittent imaging with triggering performed separately at both end diastole and end systole. During continuous high-MI imaging, a significant increase in systolic VI was noted with coronary stenoses that resulted in progressive increases in the systolic/diastolic VI ratio with greater degrees of stenosis ( P =0.003), with a mildly quadratic relation noted between the two: y=1.3 · 10 −6 · x 2 +0.01x+0.32, P &lt;0.001, r =0.76, SEE=0.14. There was no difference in capillary blood volume between end diastole and end systole at baseline. Conclusions — Capillary blood volume does not change between diastole and systole in vivo. Phasic changes in VI are noted at baseline during high-MI continuous imaging. The systolic component is negligible at baseline but increases with increasing levels of noncritical coronary stenosis because of adaptive changes in the microcirculation distal to the stenosis. Thus, the measurement of phasic changes in myocardial VI has the potential to detect coronary stenosis at rest without recourse to any form of stress.
A CASE OF COLOBOMA OF EACH LENS WITHOUT COLOBOMA OF THE IRIS OR CHOROID.
Authors: JAMES MOORES BALL
Journal: JAMA (1900)

Instances of coloboma of the crystalline lens are so rare—only about seventy having been recorded—and bring up so many interesting questions for discussion, that I feel justified in directing your attention to a case in point. S. B., male, white, aged 14, was brought to me on Oct. 7, 1899, on account of defective vision. The parents state that he was a delicate child and never was able to see distinctly. Seven years ago glasses were purchased from an optician, and two years since an ophthalmologist prescribed for him. The boy is an ungainly looking youth; he is 5 feet 7½ inches in height, weighs 100 pounds, wears a 7% hat, and has flat feet and a chicken breast. Four years ago he was operated on for adenoids. With the exception of an attack of scarlet fever he has had no serious sickness. When 3 months old he was salivated.
Long term safety of etanercept in elderly subjects with rheumatic diseases
Authors: R Fleischmann
Journal: Annals of the Rheumatic Diseases (2005)

<b>Objectives:</b> To determine the long term safety profile of the tumour necrosis factor (TNF) antagonist etanercept in subjects with rheumatoid arthritis (RA), psoriatic arthritis (PsA), or ankylosing spondylitis (AS) aged ⩾65 years in comparison with subjects aged &lt;65 years. <b>Methods:</b> Safety data from an integrated database of 4322 subjects enrolled in 18 RA trials, 2 PsA trials, and 2 AS trials were analysed. Safety end points included subject incidence of all adverse events (AE), serious adverse events (SAE), infectious events (IE), medically important infections (MII), and deaths. Events of particular interest in subjects treated with TNF modulating biological treatments, including demyelinating diseases, tuberculosis, lymphomas, and cardiovascular diseases, were also evaluated. <b>Results:</b> The incidence of AE, SAE, IE, MII, and malignancies was not significantly raised in elderly subjects in comparison with subjects aged &lt;65 years. No cases of tuberculosis were reported in the trials. Demyelinating diseases were seen only in subjects aged &lt;65 years. The incidence and types of death in the elderly subjects were consistent with the expected rates for subjects of comparable age. <b>Conclusions:</b> Etanercept is a generally safe and well tolerated biological agent for treatment of rheumatological diseases in the elderly, and the risk of AE in these studies was no greater in subjects aged ⩾65 years than in younger subjects.
The Foreign Medical Graduate — A Time for Action
Authors: Charles C. Sprague
Journal: New England Journal of Medicine (1974)

Crisis, scandal, catastrophe, immoral, etc., are words that have been used to describe the problem of the foreign medical graduate (FMG) in the United States. Such words are so shopworn these days that they have little or no impact on the reader. The problem is a serious one that demands both attention and substantive action in the immediate future.Two excellent articles in this and last week's issue of the Journal provide the reader with data regarding the rapidly escalating numbers of FMG's immigrating to this country, the quality of their education, and the effect of their entry on the . . .
Medical Parasitology. A Basic Systems Program
Authors: Eli Chernin
Journal: JAMA (1964)

<b>Outline of Medical Parasitology.</b>By John E. Larsh, Jr. 342 pp, with 64 illustrations by Adele Spiegler. Paper. $6.95. Blakiston Division, McGraw-Hill Book Co., 330 W 42nd St, New York 10036, 1964 The programmed text,<i>Medical Parasitology,</i>is essentially a stepwise array of "fill-in-the-blank" statements. The student writes in a word or phrase, compares each answer with one provided, corrects accordingly, and proceeds to the next "frame." About one third of the 900odd frames relate to parasitic protozoa and the rest to metazoan parasites excluding arthropods. Disclaiming comprehensive scope, the preface states that "the emphasis is on morphology, life cycles, and laboratory diagnosis, with some attention to preventive measures; there is minimal coverage of symptomatology and no coverage of treatment. Students are therefore expected to use the standard textbooks to supplement the material covered in the programmed textbook and in the laboratory." The merits of programmed instruction aside, I cannot
Toddler Eats Clonidine Patch and Nearly Quits Smoking for Life
Authors: Howard M. Corneli
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Clonidine has recently been advocated as an aid in smoking cessation.<sup>1,2</sup>Should it prove useful, it is likely that childhood ingestions of clonidine, already common, would increase. We recently treated a child with a toxic reaction due to ingestion of clonidine from a transdermal patch prescribed for smoking cessation. <h3>Report of a Case. —</h3> A 2-year-old child presented to the emergency department with a history of progressive lethargy over several hours. Examination revealed a heart rate of 75 beats per minute, blood pressure of 90/50 mm Hg, 2-mm pupils, and gasping respirations. The child responded to pain only by withdrawal; she did not open her eyes or speak. Her parents denied exposure to prescription medicines or heart medicines and, when asked specifically, denied exposure to clonidine. Routine urine toxicology screens by chromatography were negative on two samples taken within five hours of ingestion. The child was
Shouldn't patients decide who should access their records?
Authors: Joan Higgins
Journal: BMJ (2004)

EDITOR—Much misunderstanding exists in the NHS and other organisations about the Data Protection Act, but to deal with these concerns by granting clinical researchers freer access to confidential patient information, as suggested by Peto et al, would be excessive.1 2 The Department of Health last year published a code of practice on patient confidentiality that should ensure that custodians of medical records are aware …