tbuckley/cabot-search huggingface dataset:
Alcohol tolerance after proximal gastric vagotomy.
Authors: A F Moodie, C M Royston, J Spencer
Journal: Gut (1975)

Alcohol tolerance has been studied in 10 patients after proximal gastric vagotomy and six patients after truncal vagotomy and antrectomy. No difference in alcohol tolerance was found before and after proximal gastric vagotomy, while an increased rate of absorption with higher blood levels of alcohol were found after truncal vagotomy and antrectomy.
Discrepancy between Gleason Scores of Biopsy and Radical Prostatectomy Specimens
Authors: &Idot;.T. K&ouml;ksal, F. &Ouml;zcan, T.C. Kad&inodot;o&gbreve;lu, T. Esen, I. K&inodot;l&inodot;&ccedil;aslan, M. Tun&ccedil;
Journal: European Urology (2000)
Clinical and Experimental Observations of Farmer's Lung Disease.
Authors: H. O. Sieker
Journal: Annals of Internal Medicine (1962)

s1 April 1962Clinical and Experimental Observations of Farmer's Lung Disease.H. O. Sieker, M.D. (Assoc.), N. J. David, M.D., H. I. Horowitz, M.D.H. O. Sieker, M.D. (Assoc.)Search for more papers by this author, N. J. David, M.D.Search for more papers by this author, H. I. Horowitz, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-690_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFarmer's lung disease has been recognized as a syndrome consisting of fever, headache, malaise, cough, and respiratory distress associated with exposure to dust from grains, hay, or fodder. It is the purpose of this report to describe the clinical syndrome as observed in four young adult farm workers who developed symptoms simultaneously after a common exposure. Observations were made with experimental animals using the same material which produced symptoms in these patients in order to elucidate the pathogenesis of farmer's lung disease.The history was quite similar for each of the individuals, although the symptoms varied in degree. Within four... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, N. C. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 690-690KeywordsDustFeversHeadachesLungsPathogenesisPneumoniaPulmonary diseasesYoung adults Issue Published: 1 April 1962 PDF DownloadLoading ...
Skin Immunofluorescence in Infective Endocarditis
Authors: Mitchell B. Lowenstein
Journal: JAMA (1977)

Immunofluorescent microscopy was performed on the clinically normal skin of 3 patients with infective endocarditis, 3 patients with bacteremia, and 6 normal subjects. Perivascular deposition of immunoglobulin and complement was demonstrated in two of the three patients with infective endocarditis and in none of the bacteremic or control subjects. (<i>JAMA</i>238:1163-1165, 1977)
Diseases of the Heart
Authors: Richard J. Jones
Journal: JAMA (1991)

This is a multiauthored textbook of cardiology from the United Kingdom. It is edited by D. G. Julian of the British Heart Foundation, and the coeditors are from St George's Hospital Medical School, the National Heart Hospital, the University Hospital of Wales, and the National Heart and Lung Institute in London. They have recruited 53 other contributors from the British Isles and one each from South Africa, the United States, Belgium, and Holland. The first section, "Normal and Abnormal Cardiac Function," reviews cardiac anatomy and physiology and acute and chronic heart failure. Following a long chapter on the treatment of heart failure, it concludes with nine pages devoted to heart and heart-lung transplantation. This brief but authoritative summary of this topic, which is not discussed again, even though it may be the ultimate treatment of heart failure, seems out of place in the introductory section. Fifteen chapters are devoted to
Deaths from asthma.
Authors: A. J. Akhtar
Journal: BMJ (1968)

pupils; and in another, a woman of 38, the clinical picture closely resembled disseminated sclerosis.Nearly half (13 cases) were over the age of 60, and 6 of them were over the age of 70.It came as a surprise to find such a large number in my files.Comparable figures in the same period of other neurological diseases are subacute combined degeneration 32 cases, syringomyelia 27 cases.The figures confirm the view that the era of neurosyphilis is still very much with us.-I am, etc.,
Relevance of asbestos bodies in sputum
Authors: H Teschler, AB Thompson, R Dollenkamp, N Konietzko, U Costabel
Journal: European Respiratory Journal (1996)

The presence of asbestos bodies (ABs) in sputum specimens of individuals with occupational asbestos exposure has been well-documented. The aim of this study was to determine their clinical relevance in comparison to the concentration of AB in bronchoalveolar lavage (BAL) and lung tissue. Subjects were included following a well-documented exposure of asbestos history (n = 93) or BAL fluid analysis positive for ABs (n = 42). The subjects with a well documented history of AB exposure were divided into three groups: heavy (Group 1, n = 29); moderate (Group 2, n = 31); or occasional exposure (Group 3, n = 33). BAL fluid was available from all subjects, and lung tissue from 21 subjects. To assess the variability, 10 sputum positive subjects collected subsequent sputum on days 2, 7, 14, 30 and 90. ABs were determined by light microscopy after membrane filtration of specimen digests. The mean sputum AB content was highest in Group 1 (2.4 +/- 5.5 AB.mL-1), lower in Group 2 (0.2 +/- 0.3 AB.mL-1) and lowest in Group 3 (0.1 +/- 0.1 AB.mL-1) suggesting a correlation with cumulative exposure. However, many negative sputum samples were noted, when BAL specimens were positive. The AB content of sputum and BAL specimens did not correlate. ABs were found in sputum of all subjects with a tissue content of &gt; 1,000 AB-cm-3, but in none with contents of &lt; 1,000 AB-cm-3. Substantial variability of ABs was found in the five sequentially collected sputa of 10 initially positive patients (coefficient of variation 28-93%), but only two false negatives were found in these 50 samples. Thus, sputum analysis for asbestos bodies is an insensitive method for assessing the lung asbestos burden, much less sensitive than bronchoalveolar lavage fluid analysis. However, a sputum sample positive for asbestos bodies is suggestive of a high lung asbestos burden.
The effect of inhaled frusemide on airway sensitivity to inhaled 4.5% sodium chloride aerosol in asthmatic subjects.
Authors: L T Rodwell, S D Anderson, J I du Toit, J P Seale
Journal: Thorax (1993)

BACKGROUND: Frusemide inhaled by asthmatic subjects before a variety of indirect bronchial challenges inhibits the airway response to these challenges. Since inhalation of hyperosmolar saline is an indirect bronchial challenge, the effect of inhaled frusemide and its vehicle on airway sensitivity to a 4.5% sodium chloride (NaCl) aerosol challenge was investigated. METHODS: Eleven asthmatic subjects (five females, six males) who had a 20% fall in forced expiratory volume in one second after 4.5% NaCl challenge were enrolled in this double blind controlled crossover trial. Sensitivity was measured as the dose of aerosol required to provoke a 20% fall in FEV1. Frusemide (33.2 mg) or its vehicle was delivered through a Fisoneb ultrasonic nebuliser and inhaled 10 minutes before challenge with 4.5% NaCl. A Mistogen ultrasonic nebuliser was used to generate the 4.5% NaCl aerosol and FEV1 was measured before and one minute after each challenge period of 0.5, one, two, four, eight, eight and eight minutes. The doubling dose difference for PD20 was calculated. RESULTS: Frusemide or vehicle had no effect on baseline lung function. The geometric mean PD20 after vehicle was 1.3 ml with a 95% confidence interval of 0.7-2.3 and after frusemide was 8.2 ml with a 95% confidence interval of 4.7-14.1. This represented a 2.6 doubling dose increase in PD20 after frusemide inhalation. In five of the 11 subjects an increase from baseline FEV1 occurred after exposure to 4.5% NaCl challenge in the presence of frusemide. This transient bronchodilatation may be caused by the release of prostaglandin E2. CONCLUSION: Inhalation of frusemide is very effective in delaying airway narrowing induced by an aerosol of 4.5% NaCl in asthmatic subjects.
Protein 4.1 deficiency associated with an altered binding to the spectrin-actin complex of the red cell membrane skeleton.
Authors: F Lorenzo, N Dalla Venezia, L Morlé, F Baklouti, N Alloisio, M T Ducluzeau, L Roda, P Lefrançois, J Delaunay
Journal: Journal of Clinical Investigation (1994)

Protein 4.1 has been defined as a major component of the subcortical skeleton of erythrocytes. It binds the spectrin--actin scaffold through a 10-kD internal domain. This binding requires an essential 21-amino acid sequence motif, Motif I, which is retained by alternative splicing at the late stage of erythroid differentiation. We here analyze the molecular basis of heterozygous 4.1(-) hereditary elliptocytosis, associated with protein 4.1 partial deficiency, in nine related French families. cDNA sequencing revealed a single codon deletion (AAA) resulting in a lysine residue deletion within the 10-kD binding domain, 3' of Motif I. The mutated allele was designated allele 4.1 Aravis. In order to assess the functional effect of the codon deletion, recombinant 10-kD constructs were made and various binding assays were performed using spectrin, purified spectrin-actin complex, or red cell membranes. These experiments demonstrated that the deletion of the Lys residue clearly prevents the binding capacity. Similar results were obtained with a construct containing the Lys residue but lacking Motif I. These data strongly suggest that the binding site to the spectrin-actin complex must contain the Lys 447 (or 448), and therefore resides not only on Motif I but extends 3' of this essential motif.
Middle-Altitude Edema and Aldosterone
Authors: Willibald Wiltner
Journal: JAMA (1979)

To the Editor.—  With respect to High-Altitude Edema (239:2239, 1978), we may mention the fact that in our climatic hospital (altitude only 1,000 m) we also often notice the phenomenon of higher water intake, water retention, and moderate edema during the first days of acclimatization in the cases of both healthy subjects and patients, without any bodily exercise. In asthmatic patients (approximately 1,500 to 2,000 per year) the dose of steroids administered before may often be decreased or even abandoned. We interpreted this as a stimulating effect of altitudinal climate on the adrenal cortex, promoting, among others, aldosterone secretion. To verify this, after experimenting with other laboratory methods, this year we started to use radioimmunoassay to follow up changes in plasma aldosterone level in those admitted to us from the plain. Results seem to corroborate the assumption.
Gordon's Medical Management of Ocular Disease
Authors: James D. Kingham
Journal: JAMA (1977)

The purpose of this book was to compile in one volume concise concepts of disease entities, their medical management, and indications for surgery, when present. Outstanding specialists have each written in their field of expertise, and all aspects of ophthalmology have been included. The opening chapter initiates on a practical basis the theme of preventive medicine. Modalities of treatment including radiation, antimicrobials, and corticosteroids follow. An anatomic journey then begins with the orbit, lids, and cornea, continues through the interior of the eye, and emerges at the retina and optic nerve. Photocoagulation and ocular injuries are covered as well. The selection of authors was done extremely well, and they have, with but a few exceptions, performed an admirable task of succinctly compiling diagnostic and therapeutic information. Quite possibly, for its major fault, this book is too succinct to provide true management value to anyone. Most of the diagnostic and treatment
Alzheimer's Disease: A Physician's Guide to Practical Management
Authors: Calvin H. Hirsch
Journal: Annals of Internal Medicine (2004)

Medical Writings: Book Notes6 April 2004Alzheimer's Disease: A Physician's Guide to Practical ManagementCalvin H. Hirsch, MDCalvin H. Hirsch, MDFrom University of California, Davis, Medical Center, Sacramento, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-7-200404060-00046 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Richter RW, Richter BZ, eds. 479 pages. Totowa, NJ; Humana Pr; 2004. $99.50. ISBN 0896038912. Order phone 973-256-1699.Field of medicine: Neurology, psychiatry, and geriatrics.Format: Hardcover book.Audience: Geriatricians and primary care physicians.Purpose: To help clinicians evaluate and manage individuals with Alzheimer disease, while illuminating current scientific understanding of this disease.Content: The text consists of 51 chapters divided into 11 sections, beginning with the scientific background of Alzheimer disease, progressing through clinical assessment and treatment, and concluding with family and caregiver issues. In between are sections on preventive strategies, future developments, and neuropsychiatric management.Highlights: The chapters ... Author, Article, and Disclosure InformationAffiliations: From University of California, Davis, Medical Center, Sacramento, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 April 2004Volume 140, Issue 7Page: 588KeywordsAlzheimer diseaseDementiaGeriatricsNeurologyNicotineOxidative stressPrimary care physiciansSoftware toolsVascular dementiaVitamin E ePublished: 6 April 2004 Issue Published: 6 April 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Correlation of Mutation Status and Survival with Predominant Histologic Subtype According to the New IASLC/ATS/ERS Lung Adenocarcinoma Classification in Stage III (N2) Patients
Authors: Prudence A. Russell, Stephen A. Barnett, Marzena Walkiewicz, Zoe Wainer, Matthew Conron, Gavin M. Wright, Julian Gooi, Simon Knight, Rochelle Wynne, Danny Liew, Thomas John
Journal: Journal of Thoracic Oncology (2013)
Effect of reversible androgen deprivation on hemoglobin and serum immunoreactive erythropoietin in men
Authors: Jed P. Weber, Patrick C. Walsh, Craig A. Peters, Jerry L. Spivak
Journal: American Journal of Hematology (1991)

Abstract To examine the role of testosterone in the maintenance of hemoglobin levels, we studied the effect of reversible androgen deprivation on hemoglobin, serum immunoreactive erythropoietin, and serum testosterone in seven men treated with a luteinizing hormone‐releasing factor (LHRH) agonist for 6 months and then followed for an additional 6 months. The mean serum testosterone level was 4.35 ± 1.05 ng/ml initially and it decreased to castrate levels in all patients by 6 months. After stopping therapy, there was a rapid increase in serum testosterone such that by 12 months the mean concentration was normal. The pretreatment hemoglobin was 15.2 ± 0.9 g/dl (mean ± SD); after 6 months of androgen deprivation it had fallen to 14.1 ± 0.4 g/dl (P &lt; 0.05). Six months after stopping therapy, the hemoglobin rose to pre‐treatment levels. Before treatment, serum immunoreactive erythropoietin was 9.5 ± 4.6 mu/ml (mean ± SD) and did not change significantly during or after the 6 month period of androgen deprivation. No significant inhibition of burst‐forming unit‐erythroid (BFU‐E) or colony‐forming unit‐granulocyte macrophage (CFU‐GM) was observed at the serum levels of nafarelin acetate obtainable in vivo. These data suggest that, within the normal range of hemoglobin in men, androgens are a determinant of the red cell mass.
Incarcerated inguinal hernia in infants.
Authors: P A Raine, D G Young
Journal: BMJ (1986)

2500 in Sweden, 3900 in the UK, and 4000 in France to 11155 in West Germany and 12000 in the USA.Since the markets of the developed world do not collectively appear to support such enormous numbers of products, it is surprising that such numbers whichare claimed to exist in hird World markets are attributed to exports from the Western world.J P GRMIN ABPI, London SWIA 2DY Does sodium restriction lower blood pressure?SIR,-Dr M R Lee and colleagues (26 July, p 266) suggest that hypertension in blacks is different from that in white people and may be more salt dependent.In rural Belize the Creoles, an Afro- Caribbean group, certainly had higher blood pres- sures than either an Amerindian (Mayan) or Amerindian-European (Mestizzo) group.'How- ever, when Creoles were compared with rural and urban Malawians (central Africans) studied using the same epidemiological techniques2 the urban Africans had the highest blood pressures.This was in spite of the urban Africans being younger, lighter and less obese and having a lower output of overnight urinary sodium than the Creoles (table ).Obviously factors other than salt intake have caused these differences and, they may not all be environmental.It may be that genetic differences between Afio-Caribbean communities are as im- portant as those between whites and blacks, and Mean blood pressres, ages, weight, body mass indx, and overnght winary sodium osuput Creoles Urban Malawians Rural Malawians Men Women Men Women Men Women Blood pressure (mm Hg) 124/66-6 115/65-4 127-5*/76-2
NHS trust will face "consequences" if gagging clause breached guidelines, warns health secretary
Authors: C. Dyer
Journal: BMJ (2013)

The health secretary for England, Jeremy Hunt, has written to the hospital trust that gagged a former chief executive from speaking out on safety concerns, asking whether the gagging clause breached NHS guidelines on whistleblowing.

Hunt has received a letter from Stephen Dorrell, chairman of the House of Commons Health Committee, asking for confirmation that Gary Walker, former chief executive of United Lincolnshire Hospitals NHS Trust, would not be pursued by lawyers if he spoke to the committee.

Walker signed a compromise agreement containing the clause when he was forced out of his job in February 2010 after his insistence that a “target culture” was threatening the safety of patients.

Walker told BBC Radio 4’s Today news programme that he and the trust’s board had concerns about patient safety and suspended Department of Health waiting time targets for non-urgent treatment in the face of extra demand for emergency cases. But he said that he was told by the East Midlands Strategic Health Authority “to …
Recurrent Ventricular Fibrillation
Authors: Sidney Alexander
Journal: JAMA (1974)

Four episodes of ventricular fibrillation refractory to medical therapy occurred in a patient with increasingly severe angina pectoris. Coronary arteriography showed 90% stenosis of the left main coronary artery. After emergency aortocoronary saphenous vein bypass surgery, the patient had no further episodes and has felt well during a 17-month follow-up period. Such surgery should be considered in patients with coronary disease in whom life-threatening arrhythmias develop.  (JAMA228:70-72, 1974)
17β-Estradiol Inhibits Ca <sup>2+</sup> Influx and Ca <sup>2+</sup> Release Induced by Thromboxane A <sub>2</sub> in Porcine Coronary Artery
Authors: Shu-Zhong Han, Hideaki Karaki, Yasuyoshi Ouchi, Masahira Akishita, Hajime Orimo
Journal: Circulation (1995)

We wished to investigate the possible mechanism of the protective effect of estrogen replacement on coronary atherosclerosis observed in postmenopausal women.Cytosolic Ca2+ concentration ([Ca2+]i) and contraction were measured simultaneously in fura 2-loaded porcine coronary arterial strips stimulated by the thromboxane A2 analogue U46619 and high-K+ depolarization in the presence and absence of 17 beta-estradiol. Pretreatment with 17 beta-estradiol (30 nmol/L to 30 mumol/L) inhibited the sustained elevation of [Ca2+]i and the sustained contraction induced by 300 nmol/L U46619. Higher concentrations of 17 beta-estradiol (1 to 100 mumol/L) also inhibited the U46619-induced transient increase in [Ca2+]i and contraction in the absence of extracellular Ca2+. In the strips precontracted by 90 mmol/L K+, 17 beta-estradiol (30 mumol/L) inhibited the increases in [Ca2+]i and contraction to resting levels. In contrast, 30 mumol/L 17 beta-estradiol only partially inhibited the U46619-induced sustained contraction, despite complete inhibition of the sustained increase in [Ca2+]i. Verapamil (10 mumol/L) also strongly inhibited the sustained increase in [Ca2+]i induced by 300 nmol/L U46619, with a partial inhibition of the U46619-induced sustained contraction. A subsequent addition of 30 mumol/L 17 beta-estradiol did not show an additional inhibitory effect on either the [Ca2+]i or the tension after the addition of verapamil. 17 beta-Estradiol (10 mumol/L) also inhibited the increase in [Ca2+]i and the contraction induced by cumulative addition of Ca2+ in the strips pretreated with 90 mmol/L K+. However, 17 beta-estradiol did not change the slope of the [Ca2+]i-tension curves. 17 beta-Estradiol (10 mumol/L) had no effect on the levels of cAMP and cGMP in the coronary strips.17 beta-Estradiol inhibits the contraction of coronary vascular smooth muscle mainly inhibiting Ca2+ influx without changing Ca2+ sensitivity of contractile elements. The Ca2+ channel blocker-like action of 17 beta-estradiol may explain at least a part of the antiatherosclerotic effect of estrogen.
ADMINISTRATION OF ALKALOIDS BEFORE ANESTHESIA
Authors: ISABELLA C. HERB
Journal: JAMA (1913)

In the older records in medical literature there is abundance of evidence that many of the drugs which are employed to-day and which we are prone to consider recent discoveries were used by the ancients for the relief of pain during surgical and other procedures. They made decoctions from the leaves, bark and roots of plants and trees, which they drank, inhaled the fumes of or applied locally. In order to produce sufficient insensibility for operative measures very large doses had to be given. As a result patients frequently remained unconscious for hours or slept on to death. When the anesthetic properties of nitrous oxid, ether and chloroform were discovered, these agents rapidly replaced the drugs employed at that time, but it was generally thought necessary or expedient to reinforce them with drugs possessing hypnotic virtues. Morton, for example, gave large doses of opium before administering ether. As the action
Management of food allergies in schools: A perspective for allergists
Authors: Michael C. Young, Anne Muñoz-Furlong, Scott H. Sicherer
Journal: Journal of Allergy and Clinical Immunology (2009)

Epidemiologic studies indicate that food allergy has increased among school-aged children and now affects approximately 1 in 25. Food allergy and other triggers of anaphylaxis pose considerable challenges in the school setting. The cornerstones of management include methods to prevent relevant exposure to allergens and plans to recognize and treat allergic reactions and anaphylaxis. Numerous studies have identified gaps in the implementation of procedures to address these simple tenets. Guidelines and policies have been proposed from various stakeholders to improve the safety and management of schoolchildren with food allergy and anaphylaxis. However, there remain knowledge gaps that preclude suggesting definitive evidence-based guidelines to approach all aspects of management. The allergist plays a key role in guiding families, schools, administrators, and policymakers in developing meaningful plans to improve the safety of the school setting for children with food allergies and anaphylaxis. We review literature that is relevant to key elements that can assist the allergist in addressing patient- and school-specific issues. We additionally focus on areas of current controversy, provide information about available resources, and highlight areas in need of further study.