tbuckley/cabot-search huggingface dataset:
Coronary Microvascular Dysfunction and Diastolic Load Correlate With Cardiac Troponin T Release Measured by a Highly Sensitive Assay in Patients With Nonischemic Heart Failure
Authors: Seiji Takashio, Megumi Yamamuro, Yasuhiro Izumiya, Seigo Sugiyama, Sunao Kojima, Eiichiro Yamamoto, Kenichi Tsujita, Tomoko Tanaka, Shinji Tayama, Koichi Kaikita, Seiji Hokimoto, Hisao Ogawa
Journal: Journal of the American College of Cardiology (2013)
Samuel Henry Brock
Authors: Howard Barnes, Brian Williams
Journal: BMJ (2004)

Epidemiologist who discovered the Lassa fever virus-and nearly died from it Jordi Casals-Ariet, an epidemiologist and virologist, was hailed by scientists around the world when he discovered the virus that causes Lassa fever.He was nearly killed by the disease in 1969 while working with the virus in his Yale laboratory.In a high-stakes gamble and with no known treatment, his doctors decided to transfuse him with blood from a nurse who had survived Lassa fever.The blood saved his life.But colleagues say that Dr Casals' contributions are far greater than his discovery of the Lassa fever virus."He did a yeoman's work in establishing useful methods of classifying viruses," said Dr Gregory Tignor, professor emeritus at Yale, who worked with Dr Casals.Little was known about many viruses when Dr Casals started his work at Yale. "Everybody has forgotten how bad it was back then," said Dr Tignor."People didn't know what was causing encephalitis.We had no way of telling the difference between rabies encephalitis, polio encephalitis, or other causes of encephalitis.But Jordi found ways, using antigens and antibodies, to figure it out.His work was so meticulous that to this day nobody has changed his classifications because they have all held up."
Trade-Offs in Suffering and Wellbeing: The Utilitarian Argument for Primate Stroke Research
Authors: Dominic Wilkinson
Journal: The American Journal of Bioethics (2009)

Click to increase image sizeClick to decrease image size Acknowledgment Dominic Wilkinson is supported by an Oxford Nuffield Medical Fellowship, Eric Burnard Fellowship, and Royal Australasian College of Physicians Astra-Zeneca Medical Fellowship. The funders had no involvement in this work.
Serum Myoglobin Levels Predicted from Serum Enzyme Values
Authors: John E. Olerud, Louis D. Homer, Harold W. Carroll
Journal: New England Journal of Medicine (1975)

MYOGLOBINURIA is generally considered uncommon, although it has been reported in a wide variety of clinical conditions.1 The potential for acute tubular necrosis and renal failure associated with myoglobinuria is widely recognized. However, little information is available associating myoglobin levels with pathologic effects on the kidney. The scarcity of such information is related, in part, to the fact that quantitative myoglobin assays have been technically difficult to perform and not well suited for clinical use.In several case reports in which myoglobinuria and myoglobinemia have been documented, elevated serum enzyme values have been offered as confirmatory evidence of muscle injury. . . .
THE TECHNIQUE OF REMOVING THE APPENDIX VERMIFORMIS CECI; REPORT OF ONE HUNDRED CASES.
Authors: M. M. JOHNSON
Journal: JAMA (1896)

Intestinal surgery has, within the last few years, received a long-needed attention.The correct diag- nosis of the diseased condition of the appendix, and its operative treatment, has demonstrated the great possibilities of intestinal surgery.As a result we are now saving a class of patients which we have been unnecessarily burying all these many years.As there is a great diversity of opinion as to operative technique it affords a fertile field for our careful consideration.
THE ROLE OF INDUSTRIAL MEDICINE IN MEDICAL PREPAREDNESS
Authors: STANLEY J. SEEGER
Journal: JAMA (1941)

"This war is going to be one of endurance. The weapons of sea power and industrial strength work silently, and only at rare intervals do they attract the headlines." These words of Lord Halifax give special prominence to the contention that the skilled worker has become of importance equal to that of the man under arms. Loss of working time by skilled and indispensable workers, no matter what the cause, must be classed in war times as casualties which require the mobilization of medical facilities for competent handling just as do those which occur in the field. This fact was brought before the medical profession and the public by the House of Delegates last year when the importance of medical service to the industrial worker was stressed and every facility of the American Medical Association was offered for the health and safety of the American people and the maintenance of
Letter: Thrombocytopenia, haemolytic anaemia, and sarcoidosis.
Authors: M Winter
Journal: BMJ (1976)

LT)) C.7&C doe, Z sa nc,i ]122D/m4Z- graduate qualifications as the equal of similar British qualifications.The reason usually given is that holders of overseas postgraduate qualifications are not up to the same stand- ard when they come to work here as British postgraduates.The same is perhaps
Fungistatic Effects of Cell-Free Human Serum.
Authors: G. L. Baum
Journal: Annals of Internal Medicine (1961)

s1 May 1961Fungistatic Effects of Cell-Free Human Serum.G. L. Baum, M.D., F.A.C.P., D. Artis, B.S.G. L. Baum, M.D., F.A.C.P.Search for more papers by this author, D. Artis, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1053_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious work has shown that cell-free human serum is bacteriostatic and in some instances bactericidal. This has been a nonspecific effect and not related to previous immunization. The present study was done with several species of pathogenic fungi and with species that are only occasionally pathogenic for humans.Cryptococcus neoformans, Sporotrichum schenckii, Candida albicans, Penicillium species and Aspergillus species were tested for inhibition by cell-free human serum obtained by the usual method of venipuncture and frozen until the experiments were set up. Physicians and patients were sources of serum. Both individual and pooled sources were used.Culture tubes were filled... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, O. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1053-1053KeywordsCandida albicansCryptococcus neoformansFungal pathogensPhlebotomy ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
THE PRODUCTION OF ULCER OF THE STOMACH BY INJECTION OF STREPTOCOCCI
Authors: E. C. ROSENOW
Journal: JAMA (1913)

Hemorrhages, superficial erosions and definite ulceration of the mucous membrane of the stomach and duodenum occur not infrequently during severe infections in man and in experimentally infected or otherwise severely intoxicated animals. In some of these instances there can be no question but that infection in some instances plays a role in the etiology of ulcer.1Ulcer also has been produced experimentally by injecting bacteria into the gastric artery. The association of mouth and tonsillar infections with ulcer of the stomach has been emphasized. It is said that ulcer of the stomach is more common in regions in which throat infections are particularly prevalent. Clinicians have observed aggravation of symptoms in ulcer of the stomach or duodenum following sore throat. Experimental proof, however, showing that certain bacteria may have a special affinity for the stomach mucous membrane, producing a localized infection, and hence may play a role in the
More on the Common Communion Cup
Authors: Gregory L. Sheehy
Journal: Annals of Internal Medicine (1993)

Letters1 October 1993More on the Common Communion CupGregory L. Sheehy, MDGregory L. Sheehy, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-7_Part_1-199310010-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The letter by Furlow and Dougherty [1] about the common communion cup needs comment, given the media attention it has received. The presence of bacteria on the common cup has been established previously, albeit not necessarily after a Eucharistic service. No study, however, including theirs, has shown transmission of these organisms from one communicant to another. More important, I can find no evidence after searching the literature that establishes inoculation and infection through this religious custom. As outlined by Gill in his exhaustive 1988 review [2], Disease attributable to the shared common communion cup has never been ...References1. Furlow TG, Dougherty MS. Bacteria on the common communion cup (Letter). Ann Intern Med. 1993; 118:572-3. Google Scholar2. Gill ON. The hazard of infection from the shared communion cup. J Infect. 1988; 16:3-23. Google Scholar Author, Article, and Disclosure InformationAuthors: Gregory L. Sheehy, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1993Volume 119, Issue 7_Part_1Page: 638KeywordsBacteriaInoculation ePublished: 15 August 2000 Issue Published: 1 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Acute atrial fibrillation: high-dose IV amiodarone facilitates conversion to normal sinus rhythm. When is it necessary?
Authors: G. Cotter, E. Cotter-Metzkor, E. Kaluski, A. Biat, Y. Moshkovitz, I. Litinsky, M. Koren, R. Zaldenstein, A. Golik
Journal: Journal of the American College of Cardiology (1998)
Laboratory Profile Screening
Authors: Joel H. Merenstein
Journal: JAMA (1971)

To the Editor.—  Rardin in his report of Laboratory Profile Screening ( 214 :1262, 1970) has done a great disservice to those of us who daily debate the value of these profiles in our office and look for confirmatory evidence of their benefit and economy.  Rardin denies any attempt to determine the predictive value of abnormal  tests, yet he states why not extend our physical examination into a thorough chemical analysis of the blood...?  The object of  for disease is to uncover those among the seemingly well who are in fact suffering from disease. 1 Including patients requiring diagnostic work-ups because of illness is inappropriate in a report on screening. Nor is it meaningful to include patients with known diagnoses in whom screening merely confirms the presence of disease.  If we analyze the 31 patients in Rardin's groups B and C who developed new diseases after initial  failed
Automation in blood transfusion
Authors: Yang O. Huh
Journal: Hepatology (1990)

HepatologyVolume 12, Issue 3 p. 623-623 Book ReviewFree Access Automation in blood transfusion. Edited by C. Th. Smit Sibinga, P. C. Das and C. F. Hogman, 226 pp. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1989. $42.00 Yang O. Huh M.D., Yang O. Huh M.D. Division of Laboratory Medicine, The University of Texas M. D. Anderson Cancer, Center, Houston, TX 77030Search for more papers by this author Yang O. Huh M.D., Yang O. Huh M.D. Division of Laboratory Medicine, The University of Texas M. D. Anderson Cancer, Center, Houston, TX 77030Search for more papers by this author First published: September 1990 https://doi.org/10.1002/hep.1840120333AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume12, Issue3September 1990Pages 623-623 RelatedInformation
Glucocorticoids accelerate fetal maturation of the epidermal permeability barrier in the rat.
Authors: M Aszterbaum, K R Feingold, G K Menon, M L Williams
Journal: Journal of Clinical Investigation (1993)

The cutaneous permeability barrier to systemic water loss is mediated by hydrophobic lipids forming membrane bilayers within the intercellular domains of the stratum corneum (SC). The barrier emerges during day 20 of gestation in the fetal rat and is correlated with increasing SC thickness and increasing SC lipid content, the appearance of well-formed lamellar bodies in the epidermis, and the presence of lamellar unit structures throughout the SC. Because glucocorticoids accelerate lung lamellar body and surfactant maturation in man and experimental animals, these studies were undertaken to determine whether maternal glucocorticoid treatment accelerates maturation of the epidermal lamellar body secretory system. Maternal rats were injected with betamethasone or saline (control) on days 16-18, and pups were delivered prematurely on day 19. Whereas control pups exhibited immature barriers to transepidermal water loss (8.16 +/- 0.52 mg/cm2 per h), glucocorticoid-treated pups exhibited competent barriers (0.74 +/- 0.14 mg/cm2 per h; P < 0.001). Glucocorticoid treatment also: (a) accelerated maturation of lamellar body and SC membrane ultrastructure; (b) increased SC total lipid content twofold; and (c) increased cholesterol and polar ceramide content three- to sixfold. Thus, glucocorticoids accelerate the functional, morphological, and lipid biochemical maturation of the permeability barrier in the fetal rat.
Body fat of British and Dutch infants.
Authors: E M Widdowson, M J Dauncey, D M Gairdner, J H Jonxis, M Pelikan-Filipkova
Journal: BMJ (1975)

The fatty acids in the body fat of 41 British and 37 Dutch infants between birth and 1 year were determined. At birth linoleic acid contributed 1-3% of the total fatty acids of the body fat in infants in both countries. By one month its proportion in the fat of the Dutch infants was about 25% and by four months 32-37%; in the fat of the British infants it was never more than 3%. In the Dutch infants this large increase in the linoleic acid percentage was accompanied by a fall in the percentage contribution of others, particularly the saturated acids myristic, palmitic, and stearic. Infants born preterm showed changes in their fat after birth similar to those in fullterm infants. The difference between the composition of the fat of the infants in the two countries is attributed to the nature of the fat in the milk they received. Until recently most British infants who are not breast-fed have been given milks based on cow9s milk with only minor modifications. For the past 10 years many Dutch infants have been given a milk in which all the cow9s milk fat has been replaced by maize oil. Dutch infants also had a lower concentration of cholesterol in their serum than British infants, which was not unexpected. The results show that the triglycerides in the adipose tissue are profoundly influenced by the nature of the fat in the diet.
Apoptosis in Human Atherosclerosis and Restenosis
Authors: Jeffrey M. Isner, Marianne Kearney, Scott Bortman, Jonathan Passeri
Journal: Circulation (1995)

Background Apoptosis has been recognized in normal, including rapidly proliferating, cell populations and is inferred to be potentially responsible for the maintenance of stable cell numbers in tissues with various degrees of proliferative activity. Previous studies performed in rats indicated that despite the persistence of a relatively high level of injury-induced proliferative activity, total arterial smooth muscle content at 12 weeks remained unchanged from that measured at 2 weeks, suggesting that accrual of vascular smooth muscle cells is mitigated by cell death. The extent to which apoptosis may be observed in human atherosclerosis and/or restenosis, however, has not been previously established. Methods and Results We performed immunohistochemical studies on 56 specimens retrieved from patients undergoing directional atherectomy for primary atherosclerotic lesions or recurrent arterial narrowing after percutaneous revascularization (restenosis). Immunohistochemical staining disclosed evidence of apoptosis in 35 (63%) of the 56 specimens studied. When present, immunohistochemical evidence of apoptosis was typically limited to &lt;2% of cells in the specimen. The finding of apoptosis, however, was not distributed equally among four groups of specimens studied. Specimens retrieved from patients with restenosis were more frequently observed to contain foci of apoptosis than specimens retrieved from patients with primary atherosclerotic lesions. Among 14 peripheral arterial specimens from patients with restenosis, 13 (93%) contained foci of apoptosis; in contrast, apoptosis was observed in only 6 (43%) of 14 peripheral specimens from patients with primary lesions ( P =.0046). Among coronary arterial specimens, apoptosis was observed in 12 (86%) of 14 specimens from patients with restenosis versus 6 (29%) of 14 specimens from patients with primary obstructions ( P &lt;.0075). Conclusions Apoptosis is a feature of human vascular pathology, including restenotic lesions and, to a lesser extent, primary atherosclerotic lesions. The findings of the present study suggest that apoptosis may modulate the cellularity of lesions that produce human vascular obstruction, particularly those with evidence of more extensive proliferative activity.
In time and over time
Authors: Tim Smithers
Journal: Behavioral and Brain Sciences (1998)

Van Gelder's clear distinction between the quantitative nature of dynamical systems and the nonquantitative nature of computational processes provides a firm basis for distinguishing between processes that happen in time and processes that happen over time. Symbolic reasoning, the presumed basis of intelligent behavior in robots, happens over time. However, the movements and actions that robots must make to behave intelligently, happen in time. Attempting to connect the two, as classical artificial intelligence and robotics have presumed to be necessary, has produced a tension and an arbitrarily moving interface in the construction of robots. Adopting a robotic version of the dynamical hypothesis offers sound theoretical and scientific justification for those robotics researchers who continue to insist that getting the interaction dynamics of intelligent behavior right is a purely dynamical matter, and never a symbolic computational one.
Abdominal pain and malabsorption due to tissue deposition of clofazimine (Lamprene) crystals
Authors: R.F. Harvey, R.R.M. Harman, C. Black, A.E. Read, H. Baddeley, J. Davies, H.J. Espiner
Journal: British Journal of Dermatology (1977)

Journal Article Abdominal pain and malabsorption due to tissue deposition of clofazimine (Lamprene) crystals Get access R.F. Harvey, R.F. Harvey Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar R.R.M. Harman, R.R.M. Harman Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar C. Black, C. Black Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar A.E. Read, A.E. Read Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar H. Baddeley, H. Baddeley Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar J. Davies, J. Davies Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar H.J. Espiner H.J. Espiner Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Page 19, https://doi.org/10.1111/j.1365-2133.1977.tb14303.x Published: 01 December 1977
Purulent Pericarditis Caused by Group G Streptococcus
Authors: Vinod V. Kumar, Charles Herzog
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Group G streptococcus may be found as a member of the normal microbial flora of the skin, pharynx, vagina, and gastrointestinal tract.<sup>1,2</sup>Endocarditis, endovascular infections, and septic arthritis are the most common syndromes caused by group G streptococcus.<sup>3</sup>So far, group G streptococcus has not been identified as an etiological agent in purulent pericarditis. We report a case of a man with cardiac tamponade, secondary to purulent pericarditis caused by group G streptococcus. <h3>Report of a Case.—</h3> A 43-year-old male Native American with a medical history of long-term alcohol abuse was brought to the emergency department after a history of vomiting for 3 days and coffee-ground—color emesis on the day of admission. He also complained of a fever with chills 24 hours prior to admission. In the emergency department his blood pressure was 88/60 mm Hg; pulse rate, 106 beats per minute; and temperature, 37.7°C.
Retroflexion of the Iris
Authors: A. Samelson
Journal: BMJ (1872)

THE subject of the present remarks, J. Thompson, aged 9, the son of healthy parents, was apparently in perfect health until seven years old.He had never suffered from rheumatism in any form, nor was there any history of shock or violent exertion.About two years since, he complained, for the first time, of dyspncea, pain across the chest, and dizziness.lIe then had the first of a series of epileptic fits, and from that time gradually became cyanotic.
Apolipoprotein(a) Induces Monocyte Chemotactic Activity in Human Vascular Endothelial Cells
Authors: Michael Poon, Xiaoxia Zhang, Kevin G. Dunsky, Mark B. Taubman, Peter C. Harpel
Journal: Circulation (1997)

Background Elevated levels of lipoprotein(a) [Lp(a)] are associated with premature atherosclerosis; however, the mechanisms are not known. Recruitment of monocytes to the blood vessel wall is an early event in atherogenesis. Methods and Results This study has found that unoxidized Lp(a) induced human umbilical vein endothelial cells (HUVECs) to secrete monocyte chemotactic activity (MCA), whereas LDL under the same conditions did not. In the absence of HUVECs, Lp(a) had no direct MCA. Endotoxin was shown not to be responsible for the induction of MCA. Actinomycin D and cycloheximide inhibited the HUVEC response to Lp(a), indicating that protein and RNA synthesis were required. The apolipoprotein(a) [apo(a)] portion of Lp(a) was identified as the structural component of Lp(a) responsible for inducing MCA. Lp(a) and apo(a) also stimulated human coronary artery endothelial cells to produce MCA. Granulocyte-monocyte colony–stimulating factor (GM-CSF) antigen was not detected in the Lp(a)-conditioned medium, nor was monocyte chemoattractant protein-1 mRNA induced in HUVECs by Lp(a). Conclusions These findings suggest that Lp(a) may be involved in the recruitment of monocytes to the vessel wall and provide a novel mechanism for the participation of Lp(a) in the atherogenic process.
131 Female HCV cirrhosis liver transplant recipients have worse fibrosis progression due to recurrent hcv than male HCV recipients
Authors: E. Cholongitas, L.S. Belli, D. Samonakis, P. Burra, A.B. Alberti, C. Zavaglia, A. Quaglia, S. Fagiuoli, M. Vangeli, L. De Carlis, S. Boninsegna, D. Patch, B.R. Davidson, K. Rolles, U. Cillo, C. Camma, A.K. Burroughs, G. Pinzello
Journal: Journal of Hepatology (2006)