tbuckley/cabot-search huggingface dataset:
AB1167-HPR Cross-Cultural Adaptation, Reliability and Validity of the Turkish Version of the Upper Limb Functional Index (ULFI)
Authors: E. Tonga, P. Gabel, A. Tekindal, C. Sarıal
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The Upper Limb Functional Index (ULFI) is a patient reported outcome measure with sound clinimetric properties and clinical viability for determination of upper limb status and impairment. To date, no validated Turkish version is available. <h3>Objectives</h3> The purpose of this study is to cross-culturally adapted the ULFI for Turkish-speaking patients (ULFI-Tk) and determine the psychometric properties of reliability, validity, factor structure in a Turkish population with upper limb problems. <h3>Methods</h3> The ULFI English version was culturally adapted and translated into Turkish and back-translated according to established guidelines. Patients (n=l02, 70% female, age 49.1±16.6) with upper limb disorders completed the ULFI-Tk at baseline and day-three for test-retest reliability. The Disability of Arm, Shoulder and Hand (DASH) Turkish version was concurrently completed as a criterion. Additional psychometric properties were determined for internal consistency (Chronbach9s α), criterion validity and factor structure. <h3>Results</h3> ULFI-Tk demonstrated good internal consistency (α=0,87) and reliability (ICC=0.72,CI=0.58-0.80). Factor analysis demonstrated two factor structures, explaining 31,23% of total variance. Pearson9s correlation coefficient (r=0,679;p&lt;0,05) revealed modarete criterion validity between the ULFI and DASH. <h3>Conclusions</h3> The ULFI-TK demonstrated a 2 factor 25 item structure and is reliable and valid instrument. The ULFI-Tk consists of simple and easily understood words therefore it may be used to assess upper limb musculoskeletal disorders in Turkish speaking patients. <h3>References</h3> Badalamente M, Coffelt L, Elfar J, Gaston G, Hammert W, Huang J, Lattanza L, Macdermid J, Merrell G, Netscher D, Panthaki Z, Rafijah G, Trczinski D, Graham B &amp; American Society for Surgery of the Hand Clinical Trials and Outcomes Committee (2013b): Measurement scales in clinical research of the upper extremity, part 2: outcome measures in studies of the hand/wrist and shoulder/elbow. J Hand Surg Am 38, 407-412. Gabel CP, Michener LA, Melloh M &amp; Burkett B (2010a): Modification of the Upper Limb Functional Index to a Three-point Response Improves Clinimetric Properties. J Hand Ther 23, 41-52 Gabel CP, Burkett B. The Upper Limb Functional Index: Development and Determination of Reliability, Validity, and Responsiveness. J Hand Ther. 2006;19:328–49. Gabel CP, Yelland M, Melloh M &amp; Burkett B (2010b): A modified QuickDASH-9 provides a valid outcome instrument for upper limb function. BMC Musculoskelet Disord 10, 161. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4506
Relation between angiotensin-converting enzyme II genotype and cardiovascular events in patients with hypertrophic cardiomyopathy
Authors: Akiyoshi Ogimoto, Mareomi Hamada, Jun Nakura, Yuji Shigematsu, Yuji Hara, Tomoaki Ohtsuka, Jun Suzuki, Tsuyoshi Matsunaka, Tetsuro Miki, Jitsu Higaki
Journal: Journal of the American College of Cardiology (2003)
Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes
Authors: Constantina Christodoulou, Tyler A. Longmire, Steven S. Shen, Alice Bourdon, Cesar A. Sommer, Paul Gadue, Avrum Spira, Valerie Gouon-Evans, George J. Murphy, Gustavo Mostoslavsky, Darrell N. Kotton
Journal: Journal of Clinical Investigation (2011)

The directed differentiation of iPS and ES cells into definitive endoderm (DE) would allow the derivation of otherwise inaccessible progenitors for endodermal tissues. However, a global comparison of the relative equivalency of DE derived from iPS and ES populations has not been performed. Recent reports of molecular differences between iPS and ES cells have raised uncertainty as to whether iPS cells could generate autologous endodermal lineages in vitro. Here, we show that both mouse iPS and parental ES cells exhibited highly similar in vitro capacity to undergo directed differentiation into DE progenitors. With few exceptions, both cell types displayed similar surges in gene expression of specific master transcriptional regulators and global transcriptomes that define the developmental milestones of DE differentiation. Microarray analysis showed considerable overlap between the genetic programs of DE derived from ES/iPS cells in vitro and authentic DE from mouse embryos in vivo. Intriguingly, iPS cells exhibited aberrant silencing of imprinted genes known to participate in endoderm differentiation, yet retained a robust ability to differentiate into DE. Our results show that, despite some molecular differences, iPS cells can be efficiently differentiated into DE precursors, reinforcing their potential for development of cell-based therapies for diseased endoderm-derived tissues.
Ischaemic colitis due to myxoedema.
Authors: V R Kale, D A Woodward
Journal: BMJ (1974)

hepatitis and hepatitis-B antigen was shown to be present by both haenmalutination and electrophoresis.This case cannot, of course, be claimed to provide proof of a causal association between acupuncture and serum hepatitis.The possibility of transfer of infection by an inadequately sterilized needle should, however, be borne in mind.-Iam, etc.,
Outcomes Using a Graded Protocol for Open Food Challenges
Authors: Alisa K. Brennan, Sarita U. Patil, Jude Fleming, Joshua A. Boyce, Elisabeth S. Stieb, Margaux Nichols, Rajashri Shuba Iyengar, Perdita Permaul, Jolan E. Walter, Paul Hesterberg, Wayne G. Shreffler
Journal: Journal of Allergy and Clinical Immunology (2013)
My Plastic Pietà
Authors: John L. Wright
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NHS trust admits negligent incontinence care harmed many women
Authors: C. Dyer
Journal: BMJ (2011)

Hundreds of women are claiming compensation for operations carried out by consultant urogynaecologist George Rowland, in a case which is expected to cost the NHS millions of pounds.

Liverpool Women’s NHS Foundation Trust is being sued by around 400 women, in one of the biggest group actions against the NHS. The General Medical Council has placed conditions on Mr Rowland’s practice, banning him from carrying out urogynaecological surgery and requiring him to confine his practice to NHS posts in general gynaecology.

Solicitor Ian Cohen of Goodmans Law, who …
SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer
Authors: Mei Ming, Weinong Han, Baozhong Zhao, Nagalingam R. Sundaresan, Chu-Xia Deng, Mahesh P. Gupta, Yu-Ying He
Journal: Cancer Research (2014)

Abstract SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis. SIRT6 promoted expression of COX-2 by repressing AMPK signaling, thereby increasing cell proliferation and survival in the skin epidermis. SIRT6 expression in skin keratinocytes was increased by exposure to UVB light through activation of the AKT pathway. Clinically, we found that SIRT6 was upregulated in human skin squamous cell carcinoma. Taken together, our results provide evidence that SIRT6 functions as an oncogene in the epidermis and suggest greater complexity to its role in epithelial carcinogenesis. Cancer Res; 74(20); 5925–33. ©2014 AACR.
HYDRALAZINE POISONING
Authors: Gordon Bendersky
Journal: JAMA (1960)

A 72-year-old woman was hospitalized because of the sudden onset of hemorrhage during defecation. On admission the patient was in shock, scattered petechiae and small purpuric lesions were seen on the skin of the lower half of the body, and the gastrointestinal bleeding continued. She died on her fifth day in the hospital despite transfusions. At autopsy pathological changes of the nature of fibrinoid necrosis were found throughout the body, including an appearance called wirelooping in the renal glomeruli. This appearance is ascribed to a thickening of the basement membrane of the glomerular capillaries, which appear patent in the sections because of the rigidity of their walls. All types of blood vessels were involved in a proliferative and necrotizing process. The changes were attributed to poisoning with hydralazine, which the patient had been taking for hypertension in doses of 100 mg. daily for two years.
Aspirin injury and H pylori
Authors: A Schmassmann
Journal: Gut (2002)

The role of Helicobacter pylori in aspirin induced gastric injury

Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) cause the vast majority of peptic ulcers and their complications. However, their interaction remains extremely controversial. The study of Yoshida et al in this issue of Gut 1 aimed to address this issue by investigating the influence of experimental H pylori infection on gastric mucosal injury induced by aspirin in male Mongolian gerbils [see page 594]. 

The study found that aspirin caused more extensive haemorrhagic erosions associated with greater myeloperoxidase activity (an index of neutrophil accumulation), thiobarbituric acid reactive substance concentrations (an index of lipid peroxidation), and KC/GRO concentrations (a chemoattractive cytokine in rodents) in infected than in uninfected gerbils.

Furthermore, the authors repeated the experiments in gerbils pretreated with antineutrophil serum which reduced circulating neutrophils by 77%. Erosion index, myeloperoxidase activity, and thiobarbituric acid reactive substance concentration (but not KC/GRO concentration) were significantly less in such neutrophil depleted gerbils exposed to H pylori plus aspirin than in similarly exposed animals treated with control serum. Inhibitory effects on mucosal damage by antineutrophil serum administration was much greater in H pylori infected gerbils (65%) than in uninfected …
Influence of weight, body mass index and lifestyle factors on radiographic features of lumbar disc degeneration
Authors: S. R Pye, D. M Reid, J. E Adams, A. J Silman, T. W O'Neill
Journal: Annals of the Rheumatic Diseases (2007)

Intervertebral disc degeneration is characterised radiologically by the presence of osteophytes, disc space narrowing and endplate sclerosis. Various lifestyle factors including occupational and recreational physical activity, obesity and smoking have been reported to be associated with the occurrence of lumbar disc disease, although the results from studies are not always consistent, with few studies looking at associations with the component radiographic features of the disease.1–9 We studied a population-based sample of men and women to determine the association between weight, body mass index (BMI), regular levels of physical activity, smoking and radiographic features of lumbar disc degeneration.

Men and women aged ⩾50 years were recruited for participation in a screening …
Antidiuretic function in Sheehan's syndrome.
Authors: F Bakiri, M Benmiloud
Journal: BMJ (1984)

Twenty patients with postpartum hypopituitarism underwent a dehydration test followed by the administration of synthetic arginine-vasopressin (DDAVP; desmopressin). Panhypopituitarism was confirmed by hormonal assays in the basal state and after stimulation with combined luteinising hormone releasing hormone-thyrotrophin releasing hormone-insulin. All the patients were given replacement therapy with hydrocortisone and thyroid hormones. Results were compared with those in 12 normal women. Urinary concentrating ability was diminished in the patients as compared with the controls (maximum urine osmolality 688 (SEM 23) mmol (mosmol)/kg in the patients v 967 (SEM 29) mmol/kg in the controls). Also the change in urine osmolality after administration of desmopressin was greater in the patients (+9.55 (SEM 1.98)% in the patients v 2.49 (SEM 0.96)% in the controls). Partial diabetes insipidus is apparently common in Sheehan's syndrome. This association should be borne in mind when managing these patients, especially those in acute failure.
Effects of Hypoxia on Pulmonary Vascular Reactivity in Pneumonectomized Puppies and Minipigs
Authors: H. KATO, L. KIDD, P. M. OLLEY
Journal: Circulation Research (1971)

Pneumonectomy was performed on 25 1-month old beagle puppies and 13 2-month old minipigs. Three weeks or more later, pulmonary blood flow and pulmonary artery pressure were measured in the survivors and total pulmonary vascular resistance was calculated in each animal. These measurements were made at normal arterial Po 2 and at an arterial Po 2 of 31 ± 5 mm Hg produced by ventilating the animals with 10% oxygen in nitrogen. Seven normal puppies and seven normal minipigs of ages comparable to the pneumonectomized animals were studied as controls. The mean pulmonary artery pressure in the pneumonectomized puppies was not significantly different from that of the normal puppies. There was no significant pulmonary vascular response to hypoxia in the pneumonectomized puppies. The pneumonectomized minipigs had a significantly higher resting mean pulmonary artery pressure than the normals ( P &lt; 0.005). They did not, however, show a greater reactivity to hypoxia than did their normal litter mates. Both pneumonectomized and normal minipigs were more reactive to hypoxia than puppies. The minipigs were restudied approximately 16 weeks after the initial study. Four out of five animals showed a further rise in resting pulmonary artery pressure. Histological studies showed arteriolar medial hypertrophy in the minipig lungs.
Cutaneous infection by Cryptococcus laurentii
Authors: A. KAMALAM, P. YESUDIAN, A.S. THAMBIAH
Journal: British Journal of Dermatology (1977)

Cryptococcus laurentii was isolated twice from cutaneous granulomas in the leg and foot of a 40-year-old man. Histologically the cells of C. laurentii were found in groups in the dermis and also inside giant cells. There was epithelioid cell infiltration in the dermis and subcutis. An atypical mycobacterium was isolated in addition to C. laurentii. Therapy with anti-tuberculous drugs after an initial amphotericin B infusion was found to be satisfactory.
Comparison of Antihypertensive Effects of Captopril and Propranolol in Essential Hypertension
Authors: Chia M. Huang
Journal: JAMA (1981)

The antihypertensive effects of the oral converting enzyme inhibitor captopril and of propranolol were evaluated in a single-blind trial of 12 weeks in 19 ambulatory men with moderated essential hypertension (supine diastolic blood pressure [DPB], 100 to 120 mm Hg after receiving placebo for two weeks) whose sodium intake was unrestricted. The captopril group included 12 patients and the propranolol group seven. After the initial dose-finding period of four weeks, supine DBP was significantly reduced in eight patients receiving captopril and in four of the patients receiving propranolol. In these patients DBP decreased throughout the following eight weeks. In the remaining patients from each group, DBP was not reduced by either drug given alone at maximum allowable dosages during dose-finding periods, nor by combined administration in following weeks. No adverse side effects attributable to captopril were noted, except in one patient in whom proteinuria developed after seven weeks. Captopril has potential value in the treatment of moderate essential hypertension.
THE TIME TO PEAK VASODILATATION IS SIGNIFICANT DETERMINANT OF BRACHIAL ARTERY FLOW-MEDIATED VASODILATATION IN HYPERTENSION: ANALYSIS USING A NOVEL SEMI-AUTOMATIC VESSEL CHASING SYSTEM OF UNEXEF18G
Authors: Bonpei Takase, Akimi Uehata, Yoshihiro Tanaka, Masayuki Ishihara
Journal: Journal of the American College of Cardiology (2010)
Observations of the Achilles Reflex Test
Authors: Ralph F. Reinfrank
Journal: JAMA (1967)

A variety of physiologic, metabolic, and pathologic states influence the duration of the ankle reflex response as measured by simple photoelectric devices. Youth and hyperthyroidism are associated with shorter measurements. Aging, diabetes mellitus, hypothyroidism, and the puerperium are associated with prolongations of the measurements. The clinical usefulness and application of ankle reflex measurement will be limited if such measurements are regarded as exclusively related to thyroid function.
Fracture Complications: Recognition, Prevention and Management
Authors: Riad Barmada
Journal: JAMA (1988)

There are several good books available on fractures, but this publication's approach is unique. Seventeen chapters cover the various anatomic regions. Each chapter begins with a pretest comprised of several multiple-choice questions to highlight some important points and, similarly, a posttest to close the chapter. The various fractures are discussed with special emphasis on complications, including the diagnostic process and treatment. General information regarding mechanisms of fracture injuries, types of fractures, and classification is very brief, which makes it possible for the author to address a tremendous number of problems in a relatively small volume. This makes the book a valuable reference for physicians, residents, and medical students. <i>Fracture Complications</i>is well organized, and the artwork is excellent, but the content is brief in terms of total fracture care. I have enjoyed reading the book, and I believe that it is beneficial to all physicians and residents in emergency and
Sulkowitch's Test in the Diagnosis of Acute Pancreatitis
Authors: Robert B. Pfeffer
Journal: JAMA (1963)

DESPITE MANY valuable aids in the diagnosis of acute pancreatitis, in certain instances differentiation among severe diseases of the upper abdomen is difficult and important. The typical clinical picture of sudden pain, vomiting, and distention and guarding of the abdomen always leads to a consideration of pancreatitis, but other catastrophic disorders may be similarly manifested. In one case operation is mandatory and in the other contraindicated. The significant abnormal laboratory test results, increased serum amylase and lipase, hyperglycemia, glycosuria, increased urinary diastase, and hypocalcemia may not be helpful since they are present in other disorders or may be equivocal in pancreatitis. A study is reported which indicates that Sulkowitch's test, a simple bedside determination of urinary calcium, may be a valuable aid in the early diagnosis of pancreatitis. The role of the calcium ion in this disease was first pointed out in 1882 by Balser,<sup>1</sup>who applied the term
THE RELATION OF THE SERUM ANTISTREPTOLYSIN TITER TO THE EXACERBATION IN CHRONIC GLOMERULONEPHRITIS
Authors: David P. Earle, David Seegal, John D. Lyttle, Emily N. Loeb, Elizabeth L. Jost
Journal: Journal of Clinical Investigation (1942)

In the present study, the relation of the serum antistreptolysin titer to the exacerbation in chronic glomerulonephritis has been analysed.In a pre- vious study (1), an exacerbation in chronic glomerulonephritis was defined arbitrarily as an abrupt and marked increase in the degree of he- maturia.It was pointed out that slight variations in the urinary output of erythrocytes perhaps do not signify the presence of an exacerbation.Ex- acerbations were frequently associated with some impairment of renal function, generally transient in character.Twenty-eight such episodes were reported in an analysis of 68 cases of chronic glomerulonephritis.The present study is based on this material, with the addition of 5 exacerba- tions that have been observed since the completion of the earlier study.Two of these exacerba-
Tuberculin Booster Reactions and Conversions
Authors: Richard Sobel
Journal: Annals of Internal Medicine (1994)

Letters1 September 1994Tuberculin Booster Reactions and ConversionsRichard Sobel, MDRichard Sobel, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-5-199409010-00041 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Menzies and colleagues [1] remind us that the PPD (booster) response is a nonspecific reflection of “all mycobacterial sensitization.” Their data and conclusions are consistent with those of a study published by myself and colleagues several years ago [2]. We investigated an Israeli kibbutz school population to clarify the reasons for a high prevalence of positive and strongly positive PPD responses in a seventh-grade class. All but one of the school children had received bacille Calmette–Guérin immunization at birth. Responses were more prevalent and stronger in the older children and were associated with responses to PPd-G (Mycobacterium ...References1. Menzies R, Vissandje B, Rocher E, St. Germain Y. The booster effect in two-step tuberculin testing among young adults in Montreal. Ann Intern Med. 1994; 120:190-8. Google Scholar2. Sobel R, Zabelle S, Scharf SM. Increased prevalence of strongly positive tuberculin skin reactions in children from a desert agricultural community in Israel. Pediatr Infect Dis J. 1987; 6:766-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1994Volume 121, Issue 5Page: 387-388KeywordsBirthChildrenNontuberculous mycobacteriaThoraxTuberculin Issue Published: 1 September 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Skin Signs of Systemic Disease
Authors: Philip C. Anderson
Journal: JAMA (1982)

Distinguished by clarity, scholarship, and excellent photographs, this explanation of complex cutaneous signs is a first-choice textbook for internists, dermatologists, and others concerned with systemic disorders that involve the skin. Readers not acquainted with Braverman's first edition need to know that his book does not concern eczema, warts, impetigo, and such skin disorders, but it does concern metastatic cancer, carcinogenesis, dysproteinemias, all the new connective tissue diseases, hidden infections, the histocytoses, gastroenterological syndromes, necrotizing vasculitis, sarcoidosis, endocrine diseases, and much more. The second edition has been enlarged and improved over the first, reflecting the growing expertise and maturity of the author. The sections on endocrine and pigmentary disorders are especially well discussed, in part because these are of particular interest to the faculty at Yale University. Braverman's own special interest in the collagen-vascular-rheumatoid cluster of diseases is demonstrated in his well-documented chapter, which includes his own analysis of some new