<i>Tropheryma whippelii</i> in Synovial Tissue and Fluid
Authors: Xavier Puéchal, Radwan Saad, Jean-Dominique Poveda
Journal: Annals of Internal Medicine (1999)

Letters16 November 1999Tropheryma whippelii in Synovial Tissue and FluidXavier Puéchal, MD, Radwan Saad, MD, and Jean-Dominique Poveda, MDXavier Puéchal, MDLe Mans General Hospital; 72000 Le Mans, France (Puéchal)Le Mans General Hospital; 72000 Le Mans, France (Saad)Pasteur-Cerba; 75015 Paris, France (Poveda)Search for more papers by this author, Radwan Saad, MDLe Mans General Hospital; 72000 Le Mans, France (Puéchal)Le Mans General Hospital; 72000 Le Mans, France (Saad)Pasteur-Cerba; 75015 Paris, France (Poveda)Search for more papers by this author, and Jean-Dominique Poveda, MDLe Mans General Hospital; 72000 Le Mans, France (Puéchal)Le Mans General Hospital; 72000 Le Mans, France (Saad)Pasteur-Cerba; 75015 Paris, France (Poveda)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-10-199911160-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Whipple disease is a systemic infection in which 67% of patients present with articular symptoms (1). These symptoms usually precede diagnosis by a mean of 6 years (range, 6 months to 28 years) (1). The 16S ribosomal RNA (rRNA) of the causal agent of Whipple disease, Tropheryma whippelii, has recently been identified (2). Because of this, 16S rDNA primers are now used to detect this organism by polymerase chain reaction (PCR), mainly in duodenal and lymph node tissues (2-4). We have extended this approach to the diagnosis of Whipple arthritis.A patient with a 28-year history of ...References1. Vital Durand D, Lecomte C, Cathébras P, Rousset H, Godeau P. Whipple disease. Clinical review of 52 cases. The SNFMI Research Group on Whipple Disease. Société Nationale Française de Médecine Interne. Medicine (Baltimore). 1997;76:170-84. Google Scholar2. Relman DA, Schmidt TM, MacDermott RP, Falkow S. Identification of the uncultured bacillus of Whipple's disease. N Engl J Med. 1992;327:293-301. CrossrefMedlineGoogle Scholar3. Ramzan NN, Loftus E, Burgart LJ, Rooney M, Batts KP, Wiesner R, et al . Diagnosis and monitoring of Whipple disease by polymerase chain reaction. Ann Intern Med. 1997;126:520-7. LinkGoogle Scholar4. Dauga C, Miras I, Grimont P. Strategy for detection and identification of bacteria based on 16S rRNA genes in suspected cases of Whipple's disease. J Med Microbiol. 1997;46:340-7. CrossrefMedlineGoogle Scholar5. O'Duffy JD, Griffing WL, Li CY, Abdelmalek MF, Persing DH. Whipple's arthritis: direct detection of Tropheryma whippelii in synovial fluid and tissue. Arthritis Rheum. 1999;42:812-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Le Mans General Hospital; 72000 Le Mans, France (Puéchal)Le Mans General Hospital; 72000 Le Mans, France (Saad)Pasteur-Cerba; 75015 Paris, France (Poveda) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRheumatic and Musculoskeletal Features of Whipple Disease: A Report of 29 CasesRepublished: Whipple's diseaseWhipple Disease a Century After the Initial DescriptionMaladie de WhippleActinomycosis and Whipple DiseaseCultivation ofTropheryma whipplei from the synovial fluid in Whipple's arthritisManifestations articulaires des affections intestinalesManifestaciones articulares de las enfermedades intestinalesManifestations articulaires des affections intestinalesWhipple Disease RevisitedPolymerase chain reaction testing for Tropheryma whippelii in unexplained isolated cases of arthritisMaladie de WhippleWhipple’s diseaseWhipple disease and arthritis 16 November 1999Volume 131, Issue 10Page: 795-796KeywordsArthritisLymph nodesPeriodic acid SchiffPolymerase chain reactionRibosomal DNARibosomal RNAStainingSynovial fluidSystemic diseasesWeight loss Issue Published: 16 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...