Severe Hypertension Related to Caffeinated Coffee and Tranylcypromine: A Case Report
Authors: Niels van der Hoeven, Ieke Visser, Aart Schene, Bert-Jan van den Born
Journal: Annals of Internal Medicine (2014)

Letters6 May 2014Severe Hypertension Related to Caffeinated Coffee and Tranylcypromine: A Case ReportNiels van der Hoeven, MD, Ieke Visser, MD, Aart Schene, MD, PhD, and Bert-Jan van den Born, MD, PhDNiels van der Hoeven, MDFrom Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radboud University Medical Center, Nijmegen, the Netherlands., Ieke Visser, MDFrom Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radboud University Medical Center, Nijmegen, the Netherlands., Aart Schene, MD, PhDFrom Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radboud University Medical Center, Nijmegen, the Netherlands., and Bert-Jan van den Born, MD, PhDFrom Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radboud University Medical Center, Nijmegen, the Netherlands.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5009-8 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Hypertension can develop in patients receiving monoamine oxidase (MAO) inhibitors who consume tyramine-rich food, such as aged cheeses and some alcoholic beverages. Tyramine leads to increased norepinephrine release at adrenergic nerve terminals when MAO is inhibited (1, 2). In vitro studies show that caffeine inhibits MAO, suggesting that caffeine might supplement the effects of MAO inhibitors used to treat atypical depression and other disorders (3-5).Objective: To report a case of severe hypertension related to an interaction between caffeine and MAO inhibitor therapy.Case Report: In February 2013, a psychiatrist referred a 56-year-old man to us for evaluation of ...References1. Flockhart DA. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: an update. J Clin Psychiatry. 2012;73 Suppl 1 17-24. [PMID: 22951238] CrossrefMedlineGoogle Scholar2. Horwitz D, Lovenberg W, Engelman K, Sjoerdsma A. Monoamine oxidase inhibitors, tyramine, and cheese. JAMA. 1964;188:1108-10. [PMID: 14163106] CrossrefMedlineGoogle Scholar3. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51:83-133. [PMID: 10049999] MedlineGoogle Scholar4. Herraiz T, Chaparro C. Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee. Life Sci. 2006;78:795-802. [PMID: 16139309] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Radboud University Medical Center, Nijmegen, the Netherlands.Disclosures: None. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0038. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPurinergic transmission in depressive disordersThe perception of Jordanian population towards concomitant administration of food, beverages and herbs with drugs and their possible interactions: A cross‐sectional studyTranylcypromineCombination Therapy with Monoamine Oxidase Inhibitors and Other Antidepressants or Stimulants: Strategies for the Management of Treatment-Resistant DepressionTranylcypromine/caffeinated coffee interaction 6 May 2014Volume 160, Issue 9Page: 657-658KeywordsBlood pressureCaffeineCoffeeFoodHypertensionNorepinephrineTachycardiaUrineVasoconstrictionWine ePublished: 6 May 2014 Issue Published: 6 May 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...