tbuckley/cabot-search huggingface dataset:
THE QUARTERLY CUMULATIVE INDEX MEDICUS—AN APPRECIATION
Authors: Gustavus M. Blech
Journal: JAMA (1930)

<h3>To the Editor:</h3> —The recently published statement that the American Medical Association is publishing the<i>Quarterly Cumulative Index Medicus</i>at a financial loss merits serious consideration. Doubtless a larger subscription list would enable the Association to avoid the still greater deficit that will be faced in the future. An increase in subscribers would result, if it were more generally appreciated that the<i>Index</i>represents a service the value of which cannot be overestimated. Some years since I read in a German medical journal an article on the treatment of cancer. At that time the article made no particular impression on me and I forgot all about it. Even another article on this subject, condemning the method, produced no especial impression, for I had already made up my mind that the agent represented merely one of the many varieties of the dyes that had been tried experimentally without producing tangible results
Treatment of Severe Hypophosphatemia
Authors: RICHARD D. LENTZ
Journal: Annals of Internal Medicine (1978)

Aspects of phosphate biochemistry pertinent to therapy, the distribution of phosphorus in body compartments, therapeutic phosphorus preparations, prevention of hypophosphatemia, therapeutic guidelines, and side-effects of phosphorus therapy are reviewed. Severe hypophosphatemia (< 0.32 mmol/litre or < 1 mg/dl) can occur with normal or depleted body stores. Because a large amount of phosphorus may shift rapidly between the extracellular and intracellular or bone compartments, the size of a possible total body deficit cannot be estimated from the serum phosphorus level. Similar shifts may occur unpredictably during repair of hypophosphatemia. Therefore, correction of hypophosphatemia in any patient must be empiric and the response of serum levels to therapy should be followed closely. We discuss a method likely to correct hypophosphatemia while minimizing side-effects.
GP commissioners fund urgent care in bid to prevent winter crises
Authors: Z. Kmietowicz
Journal: BMJ (2013)

GP commissioners across England are putting sizeable portions of their budgets towards propping up their local emergency services this winter.

Jim Cuthbert, a GP and a lead on urgent care for Liverpool Clinical Commissioning Group, said that his group was putting £5.2m (€6.2m; $8.5m) into urgent care services in hospitals and the community above what it already commissioned. The group’s annual budget is £730m.

The prime minister announced in August that hospital emergency departments in England under strain would be able to apply for a share of a £250m fund this winter.1 The money comes from NHS efficiency savings and underspending.

One of the two hospitals serving the Liverpool CCG, Aintree University Hospital, has been given £1.6m through the government’s fund, and the CCG is giving the other hospital, Royal Liverpool Hospital, £1.2m.

For the investment the CCG expects senior clinicians to make rapid assessments in emergency departments and for turnaround times to improve. It is also asking the hospitals to introduce a model of care for frail elderly people.

“We need to do something different for elderly people,” Cuthbert told the BMJ . “We …
STROKE RISK IN POST-MENOPAUSAL WOMEN WITH ATRIAL FIBRILLATION IN THE WOMEN&amp;apos;S HEALTH INITIATIVE: A VALIDATION AND COMPARISON OF THE CHADS2 AND CHA2DS2-VASC RISK SCORES
Authors: JoEllyn Carol Moore M. Abraham, Sylvia Wassertheil-Smoller, Joseph Larson, Mina Chung, J.D. Curb, Anne Curtis, Kamakshi Lakshminarayan, Jonathan Newman, Marco Perez, Kathryn Rexrode, Nawar Shara, Allen Solomon, Marcia L. Stefanick, James C. Torner, Bruce Wilkoff, Cleveland Clinic
Journal: Journal of the American College of Cardiology (2012)
Reply to Chris R. Cardwell, Samy Suissa and Liam J. Murray's Letter to the Editor re: Helene Hartvedt Grytli, Morten Wang Fagerland, Sophie D. Fosså, Kristin Austlid Taskén. Association Between Use of β-Blockers and Prostate Cancer–Specific Survival: A Cohort Study of 3561 Prostate Cancer Patients with High-Risk or Metastatic Disease. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2013.01.007
Authors: Helene Hartvedt Grytli, Morten Wang Fagerland, Sophie D. Fosså, Kristin Austlid Taskén
Journal: European Urology (2013)
A Modified Adenine Chemically Coupled to Allergenic Molecule(s) as Inducer of Allergen-specific Th2 Cells Redirection
Authors: L. Filì, E. Cardilicchia, A. Casini, L. Maggi, C. Manuelli, F. Fassio, A. Matucci, A. Vultaggio, F. Annunziato, E. Occhiato, E. Maggi, S. Romagnani, P. Parronchi
Journal: Journal of Allergy and Clinical Immunology (2010)
LV Mechanical Dyssynchrony in Heart Failure With Preserved Ejection Fraction Complicating Acute Coronary Syndrome
Authors: Alex Pui-Wai Lee, Qing Zhang, Gabriel Yip, Fang Fang, Yu-Jia Liang, Jun-Min Xie, Yat-Yin Lam, Cheuk-Man Yu
Journal: JACC. Cardiovascular imaging (2011)
Assessment and Counseling for Women With a Family History of Breast Cancer
Authors: Kent F. Hoskins, Jill E. Stopfer, Kathleen A. Calzone, Sofia D. Merajver, Timothy R. Rebbeck, Judy E. Garber, Barbara L. Weber
Journal: JAMA (1995)

More women in all risk categories are seeking information regarding their individual breast cancer risk, and there is a need for their primary care clinicians to be able to assess familial risk factors for breast cancer, provide individualized risk information, and offer surveillance recommendations. Estimates of the number of women with a family history of breast cancer range from approximately 5% to 20%, depending on the population surveyed. Many of these women will not have a family history that suggests the presence of a highly penetrant breast cancer susceptibility gene. However, a small subset of such women will come from families with a striking incidence of breast and other cancers often associated with inherited mutations. The development and refinement of risk prediction models provide an epidemiologic basis for counseling women with a family history that does not appear related to a dominant susceptibility gene. contrast, the recent isolation of BRCA1, the localization of BRCA2, and the acknowledgement that additional breast cancer susceptibility genes must exist provide a molecular basis for counseling some high-risk women. We present a guide for primary care clinicians that may be helpful in defining families as moderate or high risk, in determining individual risk in women with a family history of breast cancer based on this distinction, and for counseling women in a setting where the data necessary to design surveillance and prevention strategies are lacking. We include criteria for selecting women who may be candidates for detection of inherited mutations in breast cancer susceptibility genes.
Multivariate prediction of in-hospital mortality associated with coronary artery bypass graft surgery. Northern New England Cardiovascular Disease Study Group.
Authors: G T O'Connor, S K Plume, E M Olmstead, L H Coffin, J R Morton, C T Maloney, E R Nowicki, D G Levy, J F Tryzelaar, F Hernandez
Journal: Circulation (1992)

BACKGROUND A prospective regional study was conducted to identify factors associated with in-hospital mortality among patients undergoing isolated coronary artery bypass graft surgery (CABG). A prediction rule was developed and validated based on the data collected. METHODS AND RESULTS Data from 3,055 patients were collected from five clinical centers between July 1, 1987, and April 15, 1989. Logistic regression analysis was used to predict the risk of in-hospital mortality. A prediction rule was developed on a training set of data and validated on an independent test set. The metric used to assess the performance of the prediction rule was the area under the relative operating characteristic (ROC) curve. Variables used to construct the regression model of in-hospital mortality included age, sex, body surface area, presence of comorbid disease, history of CABG, left ventricular end-diastolic pressure, ejection fraction score, and priority of surgery. The model significantly predicted the occurrence of in-hospital mortality. The area under the ROC curve obtained from the training set of data was 0.74 (perfect, 1.0). The prediction rule performed well when used on a test set of data (area, 0.76). The correlation between observed and expected numbers of deaths was 0.99. CONCLUSIONS The prediction rule described in this report was developed using regional data, uses only eight variables, has good performance characteristics, and is easily available to clinicians with access to a microcomputer or programmable calculator. This validated multivariate prediction rule would be useful both to calculate the risk of mortality for an individual patient and to contrast observed and expected mortality rates for an institution or a particular clinician.
Ethnic and Socioeconomic Factors as Determinants of Health Status
Authors: Sharon K. Davis
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy
Authors: Pengchao Du, Baoxia Fan, Huirong Han, Junhui Zhen, Jin Shang, Xiaojie Wang, Xiang Li, Weichen Shi, Wei Tang, Chanchan Bao, Ziying Wang, Yan Zhang, Bin Zhang, Xinbing Wei, Fan Yi
Journal: Kidney International (2013)
Mannose-rich glycosilated components isolated from the house dust mite Blomia tropicalis
Authors: Karine C Almeida, Margareth Leitao Gennari, Erika Aguiar Pereira, Deise Silva, Jair Pereira Da Cunha Junior, Federico Montealegre, Ernesto Ako Takemoti
Journal: Journal of Allergy and Clinical Immunology (2002)
Longer ambulance journeys raise mortality in patients with life threatening conditions
Authors: Lynn Eaton
Journal: BMJ (2007)

Survival of UK patients after cancer is improving but still lags behind the European average, despite the United Kingdom spending more than other countries on cancer, different sources of data published this week show.Figures from the Office for National Statistics (ONS) show that between 1999 and 2004 survival rates for most cancers in England improved.However, two studies published in Lancet Oncology (
Dying from Dementia
Authors: Greg A. Sachs
Journal: New England Journal of Medicine (2009)

As a teenager, I had the unfortunate but ultimately career-shaping experience of watching my maternal grandmother decline from Alzheimer's disease. She resided in a nursing home, where her final months were marked by repeated courses of antibiotics for infections and the use of restraints or medications to control her agitation before she died from one last infection. Seeing my grandmother in that state was so distressing that my mother eventually stopped taking the grandchildren to visit. My grandmother had little in the way of either comfort or company toward the end. In my medical training, I learned how my grandmother's . . .
Psychiatric Disorders in Youths With IDDM: Rates and Risk Factors
Authors: Maria Kovacs, David Goldston, D Scott Obrosky, Lisa K Bonar
Journal: Diabetes Care (1997)

OBJECTIVE To determine prevalence rates, associated features and risk factors for psychiatric disorders subsequent to the diagnosis of IDDM in youths. RESEARCH DESIGN AND METHODS Using a longitudinal, naturalistic design, 92 youths from 8 to 13 years old at onset of IDDM were followed from their initial diagnosis. They were repeatedly assessed by semistructured interview and diagnosed by operational criteria. RESULTS By the 10th year of IDDM and the mean age of 20 years, an estimated 47.6% of the sample developed psychiatric disorder. Major depressive, conduct, and generalized anxiety disorders were the most prevalent, and major depression had a significantly higher estimated rate (27.5%) than each other disorder. The highest incidence rates were during the 1st year of the medical condition. Initial maternal psychopathology increased the risk of psychiatric disorder in the subjects, and maternal depression was a specific risk factor for depression in the subjects. Earlier psychiatric disorder in the subjects also increased the risk of later disorder. CONCLUSIONS The results converge with findings from other studies, suggesting elevated psychiatric morbidity in contemporary samples of young people with IDDM. The morbidity partly reflects the high incidence of major depression in adolescence and generalized anxiety disorder in young adulthood. Monitoring the psychological status of young patients and their mothers may help to identify diabetic children at risk for psychiatric disorder and facilitate prevention or treatment efforts. Monitoring may be particularly beneficial during the 1st year of the IDDM.
Increased intracellular magnesium contributes to impairment of postischaemic cardiac function
Authors: S. M Krause
Journal: Cardiovascular Research (1995)

Journal Article Increased intracellular magnesium contributes to impairment of postischaemic cardiac function Get access Stephen M Krause Stephen M Krause Department of Pharmacology, Merck Research Laboratories, WP 26-265, West Point, PA 19486, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 3, March 1995, Page 438, https://doi.org/10.1016/S0008-6363(96)88603-2 Published: 01 March 1995
An Unusual Complication in Attempted Non-Surgical Treatment of Pancreatic Bile Duct Stones
Authors: M. Heinerman, R. Mann, O. Boeckl
Journal: Endoscopy (1993)

This report describes a guidewire fracture during an attempt at endoscopic treatment of pancreatic duct calculi in a patient with chronic pancreatitis, multiple pancreatic duct stenoses and pancreatic duct stones. This patient underwent endoscopic sphincterotomy in order to perform pancreatic duct drainage prior to ESWL. After sphincterotomy, a guidewire was introduced into the main pancreatic duct, but was jammed by the calculi. Neither could the guidewire be removed nor a contrast medium catheter be pushed over it, thus making ESWL impossible. A stronger pull resulted in a fracture of the wire, and a 25 mm long part which could not be removed with a Dormia basket remained in the main pancreatic duct. A Whipple's procedure became necessary as definitive treatment for the pancreaticolithiasis in this patient.
SP0115 The link between long-term conditions and mental health
Authors: C. Naylor
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Introduction/Background*</h3> The International Federation of Gynaecology and Obstetrics (FIGO) revised cervical cancer staging in 2018. We aimed to evaluate risk factors associated with lymph node macro- and micrometastases in women with early-stage cervical cancer, focusing on the revised FIGO-2018 staging system. The overall purpose was to evaluate if the stage migration related to the implementation of FIGO-2018 correctly reflects risk groups as indicated by the presence of lymph node metastases. <h3>Methodology</h3> Using data from a national prospective cohort study on sentinel lymph node (SLN) mapping in 245 women with early-stage cervical cancer, we reallocated women from FIGO-2009 to FIGO-2018 stages. We used binary and multiple regression models to investigate the risk ratio of FIGO-2018 stages and tumour characteristics associated with nodal metastases. <h3>Result(s)*</h3> Stage migration occurred in 80.4% (197/245), due to tumour size or depth of invasion in 75.1% (148/197), nodal metastases in 19.3% (38/197), and imaging in 4.5% (11/245). Downstaging to FIGO-2018 IA stages occurred in 36,7% (90/245). Six (5.7%) women with stage IA tumour characteristics were upstaged to IIIC1 due to the findings of nodal metastases. The depth of invasion ranged from 4-5 mm and the tumour size from 9-22 mm; all six metastases were SLNs. For the whole population, risk factors significantly associated with nodal metastases were FIGO-2018 <b>≥</b> IB2 (p &lt; 0.001), parametrial invasion (p &lt; 0.001), and lymphovascular space invasion (LVSI) (p &lt; 0.001). All three remained significantly associated with nodal metastases in a multivariate analysis. <h3>Conclusion*</h3> The FIGO-2018 revised staging system causes stage migration for a large proportion of women with early-stage cervical cancer. The attention on depth of invasion rather than horizontal dimension seems to reflect the risk of nodal metastases correctly. The use of sentinel node mapping in stage IA FIGO-2018 appears to be justified.
Group publishes guidance to ensure safe and ethical research in China and Europe
Authors: C. White
Journal: BMJ (2009)

An alliance of leading doctors and scientists has moved to stamp out unethical and potentially dangerous practice in burgeoning and cutting edge areas of biomedical research and development, such as stem cell research, in China and Europe.

The nine member Bionet Expert Group (www.bionet-china.org), which comprises doctors, ethicists, legal experts, and political and social scientists, has published draft guidance containing a raft of 30 recommendations in a bid to guarantee the safe and ethical treatment of patients involved in research collaborations between China and Europe.

The draft recommendations for best practice in the ethical governance of biological and biomedical research collaborations between Chinese and European scientists is the result of five workshops and conferences held across China …
TCT-576 COMPARE II: One year Clinical Data for the treatment of small vessels (&lt;2.75mm)
Authors: S.H. Hofma, Peter Smits, A.J. van Boven, Mariano Valdes, Antonio Serra, Jean-Jacques Goy, V. Voudris, J.M. Vazquez, Ramiro Trillo, A.G. Vuillomenet, Ton Slagboom, Peter den Heijer
Journal: Journal of the American College of Cardiology (2012)
A CASE OF MYXEDEMA IN WHICH THE BASAL METABOLIC RATE WAS MINUS FIFTY-SIX PER CENT.
Authors: K. M. Bowman
Journal: JAMA (1923)

This case is presented because of the low basal metabolism: minus 56 per cent. This is, as far as we can determine, the lowest reading that has been recorded.<sup>1</sup> <h3>REPORT OF CASE</h3> A single woman, aged 44, was admitted to the Boston Psychopathic Hospital, Nov. 5, 1922, apparently somewhat confused and disoriented. The family history was negative for endocrine disorders or mental disease, most of the ancestors having died of cardiac or arteriosclerotic conditions. The patient was born in Massachusetts, Aug. 23, 1878. The birth had been normal; she had been a full-term baby, weighing 8½ pounds (3.8 kg.). She had been a healthy, bottle-fed infant. Dentition had been normal. She had walked at 20 months. She had had the usual infectious diseases of childhood, including pneumonia at 12 and scarlet fever at 15. There was no history of convulsions, chorea, sleep walking, nail biting or tantrums. She was
Role of Cesarean Delivery in Preventing Neonatal Herpes Virus Infection
Authors: Ronald S. Gibbs
Journal: JAMA (1993)

For the past 30 years our incomplete understanding of perinatally acquired herpes infections has resulted in controversy. The lack of adequate data led to practice recommendations that have recently been changed regarding patients with recurrent herpes infection.<sup>1,2</sup>We now recognize that most cases of neonatal herpes infections are not preventable with current approaches.<sup>3</sup> From the late 1960s until the mid 1980s, the practice recommendation to prevent neonatal herpes consisted of performing weekly herpes cultures of the lower genital tract in women with a previous history of herpes followed by a cesarean delivery if lesions were present or if cultures were positive at the time of delivery. This practice recommendation was based on a small series of retrospectively gathered cases<sup>4</sup>and was generated without detailed knowledge of the natural history of genital or neonatal herpes (eg, differences between primary episode, nonprimary first episode, and recurrent episodes; and rates
Theory of mind in nonhuman primates: A question of language?
Authors: Colin Gray, Phil Russell
Journal: Behavioral and Brain Sciences (1998)

Two substantive comments are made. The first is methodological, and concerns Heyes's proposals for a critical test for theory of mind. The second is theoretical, and concerns the appropriateness of asking questions about theory of mind in nonhuman primates. Although Heyes warns against the apparent simplicity of the theory of mind hypothesis, she underplays the linguistic implications.
The use of individualized tumor response testing in treatment selection: second randomization results from the LRF CLL4 trial and the predictive value of the test at trial entry
Authors: E Matutes, A G Bosanquet, R Wade, S M Richards, M Else, D Catovsky
Journal: Leukemia (2012)

The use of individualized tumor response testing in treatment selection: second randomization results from the LRF CLL4 trial and the predictive value of the test at trial entry
What Do Peer Reviewers Do?
Authors: Stephen Lock
Journal: JAMA (1990)

We conducted a prospective 9-month survey to assess the refereeing work load of British Medical Journal referees, and, in particular, to compare the work loads of pediatricians and psychiatrists. Referees completed a record form for each manuscript reviewed and a questionnaire on demographic characteristics and attitudes toward refereeing. Two hundred eleven referees formed a sample of one sixth of the British Medical Journal's active referees; all remaining pediatricians (n = 67) and psychiatrists (n = 65) formed two further samples. Of the 343 referees selected, 301 returned forms or questionnaires. One hundred forty-six referees were editors or on editorial boards. They reviewed for a mean of five journals. They reviewed 1980 manuscripts (a median of 6 for the main sample, 6.5 for the pediatricians, and 8 for the psychiatrists). Most manuscripts were reviewed for journals in the referee's own specialty; only one third were reviewed for other journals. Psychiatrists did significantly more work for general journals than pediatricians (13% vs 9%). All three groups spent less than 2 hours per manuscript.