tbuckley/cabot-search huggingface dataset:
Chemoimmunotherapy Reinduction With Epratuzumab in Children With Acute Lymphoblastic Leukemia in Marrow Relapse: A Children's Oncology Group Pilot Study
Authors: Elizabeth A. Raetz, Mitchell S. Cairo, Michael J. Borowitz, Susan M. Blaney, Mark D. Krailo, Tarek A. Leil, Joel M. Reid, David M. Goldenberg, William A. Wegener, William L. Carroll, Peter C. Adamson
Journal: Journal of Clinical Oncology (2008)

To determine the tolerability and serum concentration of epratuzumab, a humanized monoclonal antibody targeting CD22, administered alone and in combination with reinduction chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL), and to preliminarily assess tumor targeting and efficacy.Therapy consisted of a single-agent phase (epratuzumab 360 mg/m(2)/dose intravenously twice weekly x four doses), followed by four weekly doses of epratuzumab in combination with standard reinduction chemotherapy. Morphologic and minimal residual disease (MRD) responses were determined at the end of this 6-week period. Serum concentrations of epratuzumab were determined before and 30 minutes after infusions, and CD22 targeting efficiency was determined by quantifying changes in CD22 expression after epratuzumab administration.Fifteen patients (12 fully assessable for toxicity) with first or later CD22-positive ALL marrow relapse enrolled on the feasibility portion of this study from December 2005 to June 2006. Two dose-limiting toxicities occurred: one grade 4 seizure of unclear etiology and one asymptomatic grade 3 ALT elevation. In all but one patient, surface CD22 was not detected by flow cytometry on peripheral blood leukemic blasts within 24 hours of drug administration, indicating effective targeting of leukemic cells by epratuzumab. Nine patients achieved a complete remission after chemoimmunotherapy, seven of whom were MRD negative.Treatment with epratuzumab plus standard reinduction chemotherapy is feasible and acceptably tolerated in children with relapsed CD22-positive ALL. CD22 targeting was efficient, and the majority of patients achieved favorable early responses.
Inflammatory Pseudotumor of the Lung With High FDG Uptake
Authors: Martin W. Huellner, Bernhard Schwizer, Irene Burger, Ingo Fengels, Reinhard Schläpfer, Christian Bussmann, Klaus Strobel
Journal: Clinical Nuclear Medicine (2010)

We present the case of a 23-year-old woman with 2 episodes of hemoptysis. Computed tomography showed a small mass lesion with an adjacent cyst in the left lower lobe. On whole-body fluorodeoxyglucose positron emission tomography/computed tomography, the lesion had a high focal fluorodeoxyglucose-uptake (SUVmax 21.0). Differential diagnosis included tuberculosis, fungal infection, and tumors such as bronchial carcinoma, sarcoma, or rare entities like endometriosis. Bronchoscopy with transbronchial biopsies failed to deliver a conclusive diagnosis. Lobectomy was performed, and histopathology presented an inflammatory myofibroblastic pseudotumor.
IMPACT OF?3/6 POLYUNSATURATED FATTY ACIDS RATIO ON THE PREVALENCE OF CORONARY ARTERY DISEASE ASSESSED BY 320-ROW CT CORONARY ANGIOGRAPHY
Authors: Satoru Kishi, Kengo Tanabe, Sen Yachi, Seitetsu Lee, Masahiko Asami, Kazuyuki Yahagi, Hironori Hara, Takuya Hashimoto, Asami Masahiko, Yoshifumi Nakajima, Masanori Taniwaki, Shuzou Tanimoto, Jiro Aoki, Hiroyoshi Nakajima, Kazuhiro Hara
Journal: Journal of the American College of Cardiology (2012)
Papillary Carcinoma in Ectopic Thyroid Detected by TI-201 Scintigraphy
Authors: TAKATOSHI MICHIGISHI, YUJI MIZUKAMI, TOSHINARI MURA, TAIZOU NOMURA, KISHICHIROU WATANABE, NORIHISA TONAMI, KINICHI HISADA
Journal: Clinical Nuclear Medicine (1991)

A 37-year-old man with papillary carcinoma in an ectopic thyroid is presented. Excisional biopsy revealed the cervical mass to be a metastasis from thyroid cancer. X-ray, ultrasonography, and computed tomography, however, failed to identify the primary tumor in the thyroid. Incidental TI-201 uptake was noted in the midline of the anterior neck, and a palpable nodule was discovered in this area. Fine needle aspiration cytology demonstrated Class V papillary adenocarcinoma, and subsequent surgery confirmed a papillary carcinoma in the ectopic thyroid. This case suggests the usefulness of TI-201 scintigraphy for the detection of ectopic thyroid malignancy.
Computed tomography colonography vs. colonoscopy for colorectal cancer screening: close call, but not closed case
Authors: M. Bretthauer, Ø. Holme, K. Garborg
Journal: Endoscopy (2013)

Computed tomography colonography (CTC) has been proposed as an alternative to colonoscopy in colorectal cancer (CRC) screening [1]. CTC is less invasive than colonoscopy and therefore it has been argued that CTC would inflict fewer complications and be less of a burden to patients, leading to better patient acceptance compared with colonoscopy [2].
Amiodarone-induced Hyperthyroidism in a Patient with Marfan??s Syndrome and Wolff???Parkinson???White Syndrome
Authors: H J A HAZENBERG, F C W TIETGE
Journal: Clinical Nuclear Medicine (1985)

In a 20-year-old patient with Marfan's syndrome and Wolff-Parkinson-White syndrome, effective amiodarone treatment had to be stopped due to serious hyperthyroidism. Diagnosis and therapy of amiodarone-induced dysthyroidism is discussed.
Getting Rid of Demons
Authors: Samuel Vaisrub
Journal: JAMA (1975)

Like demons of old, risk factors for disease and death lurk everywhere. They lie concealed in cigarette packs; they crouch behind dinner tables; they hide in water faucets; they sit in ambush on idlers' rocking chairs. And they become doubly ominous when disguised as abnormal, borderline, or atypical laboratory data. What a relief then to find that some risk factors have been recently reappraised and exonerated. One such exculpation, previously commented on in an editorial inThe Journal,<sup>1</sup>is that of coffee as a risk factor for myocardial infarction and sudden death. Dawber et al<sup>2</sup>and Klatsky et al<sup>3</sup>have provided sufficient statistical evidence to clear the delectable potion from previous suspicion<sup>4</sup>of complicity in bringing about these disastrous complications. Another gratifying report assures us that, contrary to the experience with patients who had a previous myocardial infarction,<sup>5</sup>premature ventricular beats occurring randomly in the
Anterior Sacral Meningocele-Reply
Authors: Frank M. Anderson
Journal: JAMA (1977)

<h3>In Reply.—</h3> We agree with the comments of Dr Say and colleagues that there is good support in the literature for the familial nature of anterior meningocele, and that this should be explored in every case. Our own pursuit of such investigation remains incomplete, having been frustrated by reluctance of parents or siblings or of their unavailability for examination. In none of our patients was there family history of stillborn males.
The Editor, 'The British Journal of Dermatology'. Alopecia
Authors: Morris Rosenblum, Morris Leider
Journal: British Journal of Dermatology (1967)

Journal Article The Editor, ‘The British Journal of Dermatology’. Alopecia Get access Morris Rosenblum, Morris Rosenblum City University of New York, Columbia College, New York Search for other works by this author on: Oxford Academic Google Scholar Morris Leider Morris Leider City University of New York, Columbia College, New York Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 10, 1 October 1967, Pages 568–569, https://doi.org/10.1111/j.1365-2133.1967.tb11415.x Published: 01 October 1967
Polypectomy as a diagnostic tool for ileocecal lymphoma
Authors: H. Nakamura, K. Fu, J. Matsumoto, Y. Kaji, T. Fujimori
Journal: Endoscopy (2007)

A 59-year-old man underwent a surveillance colonoscopy after endoscopic resection of multiple polyps. Colonoscopy showed a reddish and swollen ileocecal valve. Although the colonoscopy could not be introduced into the terminal ileum, the patient was asymptomatic. The surface of the swollen ileocecal valve was reddish, rather irregularly shaped, and nodular-like, mimicking a lump consisting of multiple swollen lymphoid follicles (Figure [1 ] a). Small ulcers were also partially evident on the surface, and the mass was demonstrated to be elastic-hard with biopsy forceps (Figure [1 ] b). Multiple endoscopic biopsy samples were taken from different areas, including the small ulcers, for histological evaluation, but no definite diagnosis could be obtained. As a diagnosis could not be established by repeated biopsies, polypectomy was performed to remove a larger specimen for histological evaluation. The resected specimen was sliced into two pieces, and macroscopic observation revealed that it consisted of round, whitish nodules resembling lymph nodes (Figure [2 ] a,b). Histologically, the features suggested malignant lymphoma. The patient underwent surgical resection, and the final diagnosis was diffuse large B-cell-type malignant lymphoma.
CD34‐positive acute promyelocytic leukemia is associated with leukocytosis, microgranular/hypogranular morphology, expression of CD2 and bcr3 isoform
Authors: R. Foley, P. Soamboonsrup, R.F. Carter, A. Benger, R. Meyer, I. Walker, Y. Wan, W. Patterson, A. Orzel, L. Sunisloe, B. Leber, P.B. Neame
Journal: American Journal of Hematology (2001)

Abstract Acute promyelocytic leukemia (APL) has a favorable prognosis. Current therapy includes chemotherapy used in combination with all‐trans ‐retinoic acid (ATRA). Although the differentiating effects of ATRA on promyelocytes have been well established, in vitro studies have shown that less‐differentiated APL blasts (CD34 + ) demonstrate a variable responsiveness to ATRA. To assess the clinical relevance of this finding, we analyzed a cohort of 38 patients with t(15;17) and/or PML‐RARα APL to determine the incidence and laboratory features of CD34 + APL. Thirty‐two percent (12/38) of cases were CD34 + . There was a difference in WBC at presentation between CD34 + and CD34 − cases (34.6 ± 9.2, mean ± standard error vs. 5.4 ± 2.0, P = 0.009). Patients with CD34 + APL demonstrated a micro/hypogranular phenotype (75%) ( P = 0.001), co‐expression of CD2 + (83%) ( P = 0.001), and the bcr3 isoform (100%) ( P = 0.017). In contrast, CD34 − cases demonstrated hypergranular morphology (65%), CD2 + (15%), and the bcr1 isoform (50%). A high presenting WBC count (\G10 × 10 9 /L) was associated with an inferior overall survival (Log rank = 0.0047). Patients with CD34 + APL demonstrated an incidence of early mortality of 50%. Despite a marked correlation between CD34 positivity and increased WBC count, overall survival of CD34 + and CD34 − cases did not differ significantly in our small cohort. Immunophenotypic analysis for CD34 expression should be included in future large APL trials to determine if detection of CD34 + blasts represents an independent adverse prognostic factor. Am. J. Hematol. 67:34–41, 2001. © 2001 Wiley‐Liss, Inc.
Immunogenicity and Reactogenicity of Alternative Schedules of HPV Vaccine in Vietnam
Authors: Kathleen M. Neuzil
Journal: JAMA (2011)

ERVICAL CANCER IS AN IMPORtant cause of morbidity and mortality among women throughout the world.Each year, new cases of cervical cancer occur in approximately 529 000 women and 275 000 women die. 1 An estimated 88% of deaths due to cervical cancer occur among women residing in developing countries. 1,24][5] Inadequate access to cervical cancer screening and early intervention is the main cause of this health burden inequity.Human papillomaviruses (HPVs) are the primary cause of cervical cancer.Of the more than 100 identified HPV types, HPV-16 and HPV-18 account for 70% of cervical cancer cases; however, regional variations do exist. 6,7HPV-16 and HPV-18 are included in 2 of the HPV vaccine formulations currently licensed and prequalified by the World Health Organization.][10][11] Combined with continued strengthening of simple evidence-based screening and treatment approaches, effective HPV vaccine programs could reduce cervical cancer rates in developing coun-
Corrected sinus node recovery time. Experimental physiologic and pathologic determinants.
Authors: K D Chadda, V S Banka, M M Bodenheimer, R H Helfant
Journal: Circulation (1975)

To determine the factors affecting reproducibility of sinus node recovery time, the effects of basic pacing rate, pacing duration, milliamperage, vagal and beta-adrenergic stimulation, and sinud node injury, as well as its instantaneous and daily reproducibility, were studied in 36 anesthetized dogs. Corrected sinus node recovery time (CSNRT) showed a mean variation of 9.8 plus or minus 0.4 msec at an atrial pacing rate of 200 beats/min and 29.8 plus or minus 8 msec at an atrial pacing rate of 140 beats/min (P smaller than 0.05). CSNRT increased progressively from 55.4 plus or minus 10 msec to 103.7 plus or minus 13 msec with increase in pacing rate from 140 beats/min to 200 beats/min. It was reproducible when atrial pacing was carried out for 1-5 min, although a wide variation (10-30 msec) was seen from 7-60 minutes (P smaller than 0.05). This measurement was reproducible on two consecutive days and was unaffected by changes in milliamperage. Vagal stimulation consistently prolonged the CSNRT while beta-adrenergic stimulation decreased it from 132.9 plus or minus 34.5 msec to 50.0 plus or minus 6.5 msec. Sinus node injury consistently prolonged CSNRT at all paced rates. In summary, CSNRT is reproducible only if the same pacing rate and duration are utilized. Since vagal stimulation and sinus node injury prolong this measurement while beta-adrenergic stimulation shortens it, an "abnormal" CSNRT should be assessed in terms of the possible influence of the autonomic nervous system as well as sinus node dysfunction per se.
Care of Patients
Authors: RICHARD L. LANDAU
Journal: Annals of Internal Medicine (1974)

Comments1 April 1974Care of PatientsRICHARD L. LANDAU, M.D., EDWARD N. EHRLICH, M.D.RICHARD L. LANDAU, M.D.Search for more papers by this author, EDWARD N. EHRLICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-4-559_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The American medical profession is being criticized more vigorously than at any time in the past. Some of us have wondered why. Certainly the widespread attitude of disaffection and distrust seems an unfair reward for the spectacular scientific advances in medical care achieved by our profession during the last quarter century. The rising cost of health care seems unlikely to be a major cause of this critical attitude, for what items in our economy have not risen sharply in cost? The almost inescapable conclusion is that the public's attitude toward us reflects ours toward it. The article,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Chicago Chicago, Illinois 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1974Volume 80, Issue 4Page: 559-560KeywordsHealth carePatients Issue Published: 1 April 1974 PDF downloadLoading ...
Cardiovascular Disturbances in Poliomyelitis
Authors: LOUIS WEINSTEIN
Journal: Circulation (1957)

INFECTION by the virus of poliomyelitis is not limited to the anterior horn cells.Clini- cal observation and anatomic study have indicated that more extensive involvement of the nervous system is not infrequent.Lesions of the precentral gyrus, the reticular formation in the medulla, the roof 'nuclei and vermis of the cerebellum, the posterior columns of the spinal cord, Auerbach's and Meissner's plexi, and the sympathetic ganglia have been demonstrated and, in many instances, related to specific syn- dromes.That invasion by the virus is not even limited to nervous tissues is suggested by re- covery of the agent from the blood, the myo- cardium, and from lymph nodes.Thus, from the standpoint of viral dissemination and extent of tissue alteration, poliomyelitis is a diffuse disease.Study of large numbers of pa- tients with poliomyelitis, particularly adults, reveals that the clinical manifestations may also be manifold, and not limited to mere loss of muscle power.Dysfunction of organs other than the nervous system is relatively common; in many instances it is secondary to damage of neural structures, in some it may result from direct viral invasion or secondary bacterial in- fection, and in others more than one mech- anism may be responsible.The situations that threaten life in poliomyelitis most seriously and are the most difficult to control arise not infrequently from such involvement.Thus, secondary bacterial invasion of the broncho- pulmonary tissues in the "respirator patient," acute ulcerations of the gastrointestinal tract with hemorrhage or perforation, infection of the urinary tract, or a variety of cardiovascular abnormalities may terminate life in individuals in whom muscle paralysis, although of extensive
Abstract LB-59: Amrubicin, a third-generation synthetic anthracycline, is active in anthracycline-resistant tumors
Authors: Vidya Mamidipudi, Helen Brady, Normand Richard, Sekhar Surapaneni, Lea S. Aukerman, Carla Heise, Victoria Sung
Journal: Cancer Research (2010)

Abstract Amrubicin, a third generation synthetic anthracycline and a potent topoisomerase (topo) II inhibitor, is approved in Japan for the treatment of lung cancer (both small-cell and non-small cell) and is being evaluated in a phase III trial in the North America and Europe for the second line treatment of SCLC. The aim of these studies was to evaluate the cross-resistance of amrubicin with other anthracyclines (doxorubicin, epirubicin) and the topo-II inhibitor etoposide, and to identify potential mechanisms of resistance to amrubicin. The doxorubicin-resistant cell lines H69-AR, MES-SA-DX5 &amp; NCI-ADR/RES were confirmed to be resistant to doxorubicin (∼25-fold relative resistance), however, their resistance to amrubicin was low or absent (∼2-fold relative resistance). Additionally, a number of primary human ovarian and breast tumor explants that were resistant to doxorubicin and/or etoposide retained sensitivity to amrubicin. Unlike doxorubicin, amrubicin induced DNA damage, G2M cell cycle arrest and apoptosis in both doxorubicin-sensitive and -resistant lines at or below clinically relevant plasma concentrations (∼10 uM). Furthermore, in contrast to doxorubicin, fluorescence time-lapse imaging demonstrated relatively small differences in amrubicin uptake and accumulation kinetics in doxorubicin-sensitive and resistant cell lines. Using gene expression profiling studies, we showed that a greater number of genes were regulated by amrubicin than by doxorubicin in both OVCAR8 and NCI-ADR/RES lines. Amrubicin is a moderate P-glycoprotein (Pgp) substrate; however, we demonstrated that the inhibitory effect and accumulation of amrubicin is not solely modulated by Pgp in cell lines over-expressing efflux pumps including Pgp. We postulate that the high intracellular accumulation and retention of amrubicin is a result of rapid influx due to the high intrinsic permeability and lipophilic properties of amrubicin. This may explain why amrubicin overcomes pleiotropic drug resistance. In summary, we demonstrated that amrubicin has a distinct mode of action compared with other anthracyclines, is less susceptible to typical anthracycline resistance mechanisms and therefore, may be useful in the treatment of anthracycline-resistant tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-59.
The role of atopy in grain dust-induced airway disease.
Authors: C A Blaski, W D Clapp, P S Thorne, T J Quinn, J L Watt, K L Fress, S J Yagla, D A Schwartz
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

To determine whether atopy influences the physiologic or inflammatory response to grain dust, we compared spirometric measures of airflow and bronchoalveolar lavage (BAL) measures of lower respiratory tract inflammation between demographically similar nonatopic (n = 10) and atopic (n = 10) study subjects after each of two inhalation exposures: Hanks' balanced salt solution (HBSS) and corn dust extract (CDE; 0.4 microgram of endotoxin/kg body weight). Subjects were healthy nonsmokers with similar baseline pulmonary function, without bronchial hyperreactivity, and had not participated in agriculture. Atopic subjects had two or more positive skin responses to 10 common environmental allergens. Both groups developed significant airflow obstruction and lower airway inflammation after CDE inhalation. Importantly, the magnitude of the post-CDE exposure airflow decrements, BAL cellularity, and BAL concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), IL-6, and IL-8 did not significantly differ between atopics and nonatopics. The concentrations of histamine and eosinophils in the BAL fluid were unaffected by CDE inhalation and did not significantly differ between atopics and nonatopics. Atopic status does not appear to be a significant determinant of airflow obstruction or lower airway inflammation following CDE inhalation. Our findings suggest that atopy may play, at most, a minor role in the development of grain dust-induced airway disease.
The Evolving Role of Ambulatory Arrhythmia Monitoring in General Clinical Practice
Authors: Peter J. Zimetbaum
Journal: Annals of Internal Medicine (1999)

To evaluate the efficacy of various ambulatory electrocardiographic monitors for the diagnosis of arrhythmia-related disorders and to provide recommendations for their use in clinical practice.Studies published since 1988 were identified through search of the MEDLINE database.Studies that met methodologic criteria for minimal bias and had clinical relevance were selected.Descriptive and analytic data from each study.Ambulatory electrocardiographic monitors, specifically transtelephonic continuous-loop event recorders, are highly effective for establishing a diagnosis in patients with palpitations but are less effective for establishing a diagnosis in patients with syncope. Clinicians may use these devices to monitor for nonsustained ventricular tachycardia in patients at potentially high risk for sudden arrhythmic death; however, few data are available to support this practice. Ambulatory monitors are useful for assessment of the safety and efficacy of antiarrhythmic medications and the recurrence of symptomatic supraventricular arrhythmias. New ambulatory arrhythmia monitoring devices are being developed that may facilitate outpatient management of chronic cardiac disease.Ambulatory electrocardiographic monitors, particularly transtelephonic continuous-loop event recorders, aid in the diagnosis of symptomatic arrhythmias. These devices are also useful for monitoring the effectiveness and safety of antiarrhythmic medications. Guidelines are lacking for use of these devices to assess prognosis in patients at potential risk for sudden arrhythmic death.
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study
Authors: Unhee Lim, Sophia S. Wang, Patricia Hartge, Wendy Cozen, Linda E. Kelemen, Stephen Chanock, Scott Davis, Aaron Blair, Maryjean Schenk, Nathaniel Rothman, Qing Lan
Journal: Blood (2006)